Document:

EX-10.4.1

 Exhibit 10.4.1 
 LEASE AMENDMENT AND TERMINATION AGREEMENT 
 This Lease Amendment and
Termination Agreement (this “Amendment”) is dated for reference purposes as of February 12, 2013, by and between SI 34, LLC, a California limited liability company (“Landlord”) and XenoPort, Inc., a Delaware
corporation (“Tenant”). 
 RECITALS 

A. Pursuant to that certain Lease dated February 29, 2008 (“Original Lease”) between Landlord’s predecessor in
interest, Sobrato Interests, a California limited partnership, and Tenant, Landlord leases to Tenant, and Tenant leases from Landlord, certain premises described in the Original Lease and commonly known as 3400 Central Expressway, Santa Clara,
California. Landlord has succeeded to Sobrato Interests interest in the Original Lease and the Premises, and has the full right to enter into this Amendment as the Landlord under the Lease; 

C. The Lease is currently scheduled to expire on August 27, 2013 (the “Expiration Date”). Landlord and Tenant wish
to terminate the Lease prior to the Expiration Date, subject to and upon all of the terms and conditions set forth in this Amendment. 
 NOW, THEREFORE, in order to effect the intent of the parties as set forth above and for good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Lease is
hereby amended as follows: 
 1. Early Termination Date. The Lease shall terminate effective as of February 15, 2013
(the “Early Termination Date”). Each and every Option pursuant to Section 38 of the Original Lease and the Right of First Refusal pursuant to Section 43.M of the Original Lease are hereby immediately terminated and shall
be of no further force or effect. In no event shall Tenant have the right to hold over after the Early Termination Date. If Tenant remains in possession of the Premises after the Early Termination Date without Landlord’s consent or fails to
surrender the Premises to Landlord in the condition required by the Amendment by the Early Termination Date, such hold over or failure shall not constitute a renewal or extension of the Lease Term or a month-to-month tenancy, but instead shall be on
the basis of a tenancy at sufferance, and Tenant shall be liable to Landlord for the reasonable rental value of the Premises (which shall in no event be less than one hundred fifty percent (150%) of the Base Monthly Rent) plus all other amounts
payable by Tenant under this Lease for the period of time that Tenant fails to surrender the Premises in the condition required by this Amendment. In addition, if Tenant holds over without Landlord’s consent or fails to surrender the Premises
on the Early Termination Date in the condition required by this Amendment, Tenant shall indemnify, defend with counsel reasonably acceptable to Landlord, and hold Landlord and the Landlord affiliates, successors and assigns harmless from and against
all claims, liabilities, obligations, penalties, fines, actions, losses, damages, costs or expenses (including without limitation reasonable attorneys fees) resulting from delay by Tenant in timely surrendering the Premises, which obligation shall
survive expiration or sooner termination of the Lease. If Tenant holds over after the Early Termination Date with Landlord’s consent (granted in writing after the date that this Amendment has been signed by Landlord and Tenant), such holding
over shall be construed as a month to month tenancy, at one hundred fifty percent (150%) of the Base Monthly Rent for the month preceding expiration or sooner termination of this Lease in addition to all other rent due under this Lease, and
shall otherwise be on the terms and conditions of this Lease, except those provisions relating to the Lease Term and any options to extend or renew or any rights of first refusal (which excepted provision shall be of no further force and effect).

 2. Surrender of Premises. Tenant shall deliver the Premises to Landlord on the Early
Termination Date free of subtenants and other occupants. Notwithstanding anything in the Lease to the contrary, Tenant shall surrender the Premises in the condition required by the Original Lease, except that the Premises shall be surrendered with
all Tenant Improvements and other Alterations previously consented to by Landlord (excluding furniture, telephone equipment, telephone and wiring and cabling, office equipment, and other personal property and trade fixtures) in place, and Tenant
shall have no obligation to remove such Tenant Improvements or Alterations or restore the areas affected by such Tenant Improvements or Alterations to the condition existing before the installation of such Tenant Improvements or Alterations. If any
Tenant Improvements or Alterations are removed by Tenant prior to the Early Termination Date, Tenant shall be required to repair all damage caused to the Premises by such removal, which obligation shall survive expiration or sooner termination of
the Lease. 
 3. Performance of Lease Obligations; Security Deposit. Until the Early Termination Date, Tenant shall
continue to timely perform all of its obligations under the Lease, including without limitation paying all Base Monthly Rent and all other charges attributable to the period prior to the Early Termination Date as such amounts become due. All of the
parties’ indemnification, defense and hold harmless obligations under the Original Lease shall survive the expiration or sooner termination of the Lease, as to events or conditions occurring or existing on or before such expiration or sooner
termination. In consideration of the early termination of the Lease and the resulting termination of Tenant’s continuing maintenance and repair and other obligations under the Lease following such early termination (other than its obligations
under this Amendment and those obligations that the Lease or this Amendment states survives expiration or termination of the Lease), Tenant shall continue to pay to Landlord all Base Monthly Rent, Tenant’s Allocable Share of Building and Common
Area Costs and the management fee described in Section 43.B of the Original Lease (collectively, the “Post Termination Payments”) at the time such payments would have been due under the Lease if the Lease had not sooner
terminated, and shall continue to make such Post Termination Payments up through and including the earlier to occur of (i) the date that the New Lease Condition (described below) has been fully satisfied, or (ii) the Expiration Date. As
used in this Amendment, “New Lease Condition” shall mean the occurrence of all of the following: Landlord has entered into a new lease for the Premises with a third party tenant satisfactory to Landlord in Landlord’s sole and
absolute discretion (the “New Tenant”) on terms and condition satisfactory to Landlord in Landlord’s sole and absolute discretion (a “New Lease”), the New Tenant has entered into possession of the Premises, the
lease term has commenced under the New Lease and the New Tenant has commenced to pay Landlord base monthly rent under the New Lease. Landlord makes no representation or warranty that the New Lease Condition can or will be satisfied before the
Expiration Date, shall not have any obligation to pursue or satisfy the New Lease Condition, and shall not have any liability to Tenant in the event the New Lease Condition is not satisfied before the Expiration Date for any reason. All sums due
from Tenant to Landlord under this Amendment shall bear interest from the date due until paid in full, at the interest rate set forth in Section 43.D of the Original Lease. With respect to all sums due from Tenant to Landlord under this
Amendment that are not paid within ten (10) days after written notice from Landlord that such amounts are due, Tenant shall pay a late fee on the overdue amount in accordance with the provisions in Section 6 of the Original Lease, although
such late fees may be waived in 

  
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accordance with Section 6 of the Original Lease. Post Termination Payments payable for any period less than a full calendar month shall be prorated based on the number of days in such
calendar month. Not later than thirty (30) days after the Expiration Date, Landlord shall reimburse to Tenant the Security Deposit, less all amounts applied by Landlord in accordance with Section 5 of the Original Lease, and less all
unpaid amounts due to Landlord under this Amendment; provided that in no event shall the Security Deposit be deemed a limitation of Tenant’s obligations under the Lease or this Amendment. Notwithstanding the early termination of the Lease, the
Security Deposit shall continue to be subject to all of the terms and conditions set forth in the Lease applicable to the Security Deposit, except to the extent expressly modified in this Amendment. Except as expressly set forth in this Amendment
(including without limitation Section 4 of this Amendment below), from and after the Early Termination Date neither party shall have any further rights or obligations under the Lease. 

4. No Release. Termination of the Lease pursuant to this Amendment shall in no way (i) excuse either party from any
obligation under the Lease arising prior to the Early Termination Date, (ii) constitute a release by Landlord or Tenant from any claims, liabilities or damages under the Lease arising in connection with a breach of the Lease by the other party
prior to the Early Termination Date, or (iii) affect any obligation of Landlord or Tenant under the Lease which by its terms is to survive the expiration or sooner termination of the Lease. The parties’ obligations under this Amendment
shall survive Lease termination. 
 5. Tenant’s Representations and Warranties. Tenant represents and warrants to
Landlord that the following statements are true as of the date hereof and will be true on the Early Termination Date: (i) Tenant owns and holds the entire interest of Tenant under the Lease, there exist no subleases affecting the Premises, and
Tenant has not assigned, transferred, conveyed or encumbered Tenant’s interest under the Lease or any part thereof; (ii) no contracts for the furnishing of any labor or materials with respect to improvements or Alterations in or about the
Premises are outstanding or remain unpaid; (iii) Tenant has full authority to execute and deliver this Amendment, and the person signing this Amendment on behalf of Tenant has received authority from Tenant to act on its behalf and execute and
deliver this Amendment to Landlord; and (iv) no consent of any third party is required to be obtained by Tenant in order for Tenant to enter into this Amendment or to perform its obligations hereunder, except any such consent as has been duly
obtained and is in full force and effect. Tenant shall indemnify, defend and hold harmless Landlord against any loss, cost, defense, or liability (including reasonable attorney’s fees) with respect to any breach of Tenant’s representations
and warranties set forth in this Section 5, which obligation shall survive the expiration or sooner termination of the Lease. 
 6. Miscellaneous. All capitalized terms not herein defined shall have the meanings as set forth in the Original Lease. This Amendment shall become binding on Landlord and Tenant when it has been
signed by Landlord and Tenant. In the event of any conflict or inconsistency between the terms and provisions of this Amendment and the terms and provisions of the Original Lease, the terms and provisions of this Amendment shall prevail. From and
after the effectiveness of this Amendment “Lease”, as used in the Original Lease and this Amendment, shall mean the Original Lease as amended by this Amendment. Except as modified by this Amendment, the Original Lease shall remain
unchanged and in full force and effect until the Early Termination Date, at which time it shall terminate in accordance with the terms of this Amendment. This Amendment may be executed in counterparts, all of which taken together shall constitute
one and the same instrument. Signatures to this Amendment created by the signer 

  
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by electronic means and/or transmitted by telecopy or other electronic transmission shall be valid and effective to bind the party so signing. Each party agrees to promptly deliver an execution
original of this Amendment with its actual signature to the other party, but a failure to do so shall not affect the enforceability of this Amendment, it being expressly agreed that each party to this Amendment shall be bound by its own
electronically created and/or telecopied or electronically transmitted signature and shall accept the electronically created and/or telecopied or electronically transmitted signature of the other party to this Lease. This Amendment shall be binding
upon and inure to the benefit of the parties hereto and, their successors and assigns; shall be governed by and construed in accordance with the laws of the State of California applicable to agreements made and to be wholly performed within said
State; and may not be modified or amended in any manner other than by a written agreement signed by the party to be charged therewith. If any term or provision of this Amendment or the application thereof to any persons or circumstances shall, to
any extent, be invalid or unenforceable, the remainder of this Amendment or the application of such term or provision to persons or circumstances other than those as to which it is held invalid or unenforceable shall not be affected thereby, and
each term and provision of this Amendment shall be valid and enforced to the fullest extent permitted by law. This Amendment constitutes the final and complete express of the parties’ agreements with respect to the subject matter of this
Amendment, and any prior negotiations or transmittals with respect to the subject matter of this Amendment shall be of no force or effect unless expressly set forth in this Amendment. Landlord and Tenant understand, agree and acknowledge that this
Amendment has been freely negotiated by both parties; and that in any controversy, dispute, or contest over the meaning, interpretation, validity, or enforceability of this Amendment or any of its terms or conditions, there shall be no inference,
presumption, or conclusion drawn whatsoever against either party by virtue of that party having drafted this Amendment or any portion thereof. Caption and section headings in this Amendment are for convenience of reference only, and shall not be
used to limit, extend or interpret the meaning of any part of this Amendment. 
 IN WITNESS WHEREOF, the
parties hereto have set their hands to this Amendment as of the day and date first above written. 
  

													
	Landlord:	 		 	Tenant:
			
	 SI 34, LLC,
 a
California limited liability company
	 		 	XenoPort, Inc., a Delaware corporation
		 		 		 	By:	 	 /s/ William G. Harris

	By:	 	Sobrato Interests 1,	 		 		 	William G. Harris
		 	a California limited partnership	 		 		 	Senior Vice President of Finance and Chief Financial Officer
	Its:	 	Sole Member	 		 		 
						
		 	By:	 	 Sobrato Development Companies, LLC,
 a California limited liability company
	 		 	Dated:	 	 February 12, 2013

		 	Its:	 	General Partner	 		 	
						
		 		 	By:	 	 /s/ John Michael Sobrato
	 		 	
		 		 		 	John Michael Sobrato	 		 	
		 		 	Its:	 	Manager	 		 	
				
	Dated: 	 	 2-13-13
	 		 	

  
 4EX-10.23

 Exhibit 10.23 
 AMENDED & RESTATED SEVERANCE RIGHTS AGREEMENT 
 This Amended & Restated
Severance Rights Agreement (the “Agreement”) is made and entered into by and between KENNETH C. CUNDY, PHD (the “Executive”) and
XENOPORT, INC., a Delaware corporation (the “Company”), effective as of December 20, 2012 (the “Effective Date”). The Company appreciates the important
contributions that the Executive has made as XenoPort Fellow since June 2012. The Company and the Executive now desire that the Executive continue in his current role in a more formal, non-transitional, capacity. Therefore, this Agreement replaces
and supersedes all prior agreements on the subject matter of this Agreement, including, but not limited to, the Severance Rights Agreement between the Executive and the Company dated June 1, 2012 (the “Prior Agreement”).

 1. At-Will Employment. The Company and the Executive acknowledge that the Executive’s employment has been, is and will
continue to be at-will. If the Executive’s employment terminates for any reason, whether or not in connection with a Change of Control, the Executive will not be entitled to any payments, benefits, damages, awards or compensation other than as
provided by this Agreement. 
 (a) Position and Duties. Effective on December 20, 2012, the Executive began
serving in a regular (not transitional) full time capacity as the Company’s Chief Scientific Officer. As Chief Scientific Officer, the Executive will report to, and is expected to perform the reasonable duties requested of him from time to time
by, the Company’s Chief Executive Officer. At all times, the Executive is expected to continue to comply with the Executive’s contractual and fiduciary obligations to the Company, including, but not limited to, full compliance with the
Company’s policies and procedures. 
 (b) Compensation and Employee Benefits. Executive’s current base salary
is and will continue to be $362,440.00 on an annualized basis. The Executive will continue to be eligible to participate in the Company’s employee benefit plans under the terms and conditions of those benefit plans, as may be amended from time
to time by the Company. 
 (c) Equity Compensation. The Executive currently holds a number of outstanding stock options
and unvested RSUs granted under the Company’s compensatory equity plans (the “Equity Awards”). The Company acknowledges that neither the Executive’s transition to XenoPort Fellow, nor to Chief Scientific Officer, resulted
in a break of continued service to the Company. The Executive’s Equity Awards continue to be subject to the stock plans under which they were granted, and the applicable award agreements, except as expressly modified by this Agreement.

 (i) The Company and the Executive hereby amend the Executive’s currently-outstanding Equity Awards that are
stock options (the “Current Options”) to remove the extended exercise period that was adopted by amendment to the Current Options set forth in Section 3(d) of the Prior Agreement (the “First Amendment”) so
that, as of the Effective Date, the post-termination exercise periods applicable to the Current Options will be those post-termination exercise periods in effect under the original stock option award agreements that govern each of the Current
Options, as in effect immediately before the adoption of the First Amendment. The Executive expressly acknowledges that either of the First Amendment and/or this amendment may have caused his Current Options to cease to qualify as incentive stock
options. 
 2. Conditions to Severance Benefits. All of the severance payments, benefits and rights that Executive may receive on
a termination of employment under this Agreement are subject to and 

 
contingent upon: (a) the Executive’s execution, delivery and non-revocation of an effective release of all claims against the Company and its affiliates substantially in the form
attached hereto as Exhibit A (the “Release”) as of a date not later than the 60th day following the Executive’s “separation from service”, as defined under Treasury Regulations Section 1.409A-1(h) and without regard to any alternative definition thereunder
(“Separation from Service”), (b) the Executive’s resignation from all positions the Executive holds with the Company and its affiliates as of the date of the Separation from Service (or such other date requested or
permitted by the Board of Directors of the Company (the “Board”), and (c) the Executive’s continued compliance with all of the Executive’s obligations to the Company and its affiliates, including, but not limited to,
obligations under this Agreement and the Employee Proprietary Information Agreement between the Company and the Executive, dated March 15, 2000 (such agreement, as amended from time to time, or any successor agreement, the
“Confidentiality Agreement”), (with (a) through (c) collectively referred to as the “Severance Conditions”). 
 3. Severance – No Change of Control. If the Executive’s employment with the Company is terminated (x) either (1) by the Company without Cause and other than as a result
of death or disability, or (2) by the Executive for Good Reason (either such termination, provided it is also a Separation from Service, a “Qualifying Termination”), and (y) at any time other than during the period
beginning three months prior to, and ending 18 months after the closing of, a Change of Control (such 21 month period, the “Change of Control Period”), then the Executive will be eligible to receive the following benefits, subject
to the Executive’s satisfaction of the Severance Conditions: 
 (a) Base Salary. The Company
will pay, as severance, continued payment of the Executive’s then-current base salary (ignoring any reduction in base salary that forms the basis for Good Reason) for the first 12 months following the Separation from Service, on the
Company’s normal payroll schedule; provided, however, that no payments will be made until the
60th day following the Separation from Service in order to
comply with Section 409A (such 60th day, the
“Initial Payment Date”), and on such day, the Company will make a lump sum payment of the base salary that would have been paid through the Initial Payment Date had payments commenced immediately following the Separation from
Service, with the balance paid thereafter on the original schedule. 
 (b) Pro-Rated Bonus. The Company will pay, as
severance, a lump sum payment under the terms of the annual cash bonus plan in place for the year in which the Qualifying Termination occurs, equal to the product of (i) a fraction, the numerator of which is the number of days in the calendar
year of termination from January 1 through the date of the Qualifying Termination and the denominator of which is 365 (the “Service Fraction”), and (ii) the actual cash bonus the Executive would have earned, based on
actual Company and, if applicable, individual performance, had the Executive remained employed through the payment date under the annual cash bonus plan for that year. This pro-rated bonus payment will be paid on the same date that active employees
are paid the cash bonus under that annual cash bonus plan, but in all cases not later than March 15 of the year following the year of the Qualifying Termination. 
 (c) COBRA Payments. If the Executive is participating in the Company’s group health insurance plans on the date of the Qualifying Termination, and timely elects to continue such coverage under
the Consolidated Omnibus Budget Reconciliation Act of 1985, or, if applicable, comparable state or local insurance laws (“COBRA”), then the Company will pay, directly to the COBRA carrier, as and when due, the COBRA premiums
necessary to continue such health insurance coverage for the Executive and his eligible dependents (“COBRA Continuation Payments”) until the earliest of: (i) the first 12 months of COBRA coverage following the Executive’s
Separation from Service, (ii) the expiration of eligibility for COBRA coverage, or (iii) the date when Executive or his dependents become eligible for substantially equivalent health insurance coverage in connection with new employment or
self-employment 

  
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(such period, the “COBRA Payment Period”). However, if at any time the Company determines, in its sole discretion, that the Company’s payment of the COBRA Continuation
Payments would result in a violation of the nondiscrimination rules of Section 105(h)(2) of the Internal Revenue Code of 1986, as amended (the “Code”) or any statute or regulation of similar effect (including, but not limited
to, the 2010 Patient Protection and Affordable Care Act, as amended by the 2010 Health Care and Education Reconciliation Act) or otherwise result in a material penalty to the Company, then in lieu of providing the COBRA Continuation Payments for the
remainder of the COBRA Payment Period, the Company will instead pay the Executive, on the first day of each month of the remainder of the COBRA Payment Period, a fully taxable cash payment equal to the COBRA Continuation Payments for that month,
subject to applicable tax withholdings. In all cases, the Company will make the first payment under this clause on the Initial Payment Date in an amount equal to the aggregate payments that the Company would have paid through such date had such
payments commenced on the Separation from Service, with the balance of the payments paid thereafter on the schedule described above. If the Executive becomes eligible for coverage under another employer’s group health plan or otherwise ceases
to be eligible for COBRA during the COBRA Payment Period, the Executive must immediately notify the Company of such event, and all payments and obligations under this clause will immediately cease. 

4. Severance - Change of Control Period. If the Executive suffers a Qualifying Termination during the Change of Control Period, then the
Executive will be eligible to receive the following benefits, subject to the Executive’s satisfaction of the Severance Conditions: 
 (a) Base Salary. The Company will pay, as severance, continued payment of the Executive’s then-current base salary (ignoring any reduction in base salary that forms the basis for Good Reason)
for the first 18 months following the Separation from Service, on the Company’s normal payroll schedule; provided, however, that no payments will be made until the Initial Payment Date, and on such day, the Company will make a lump sum
payment of the base salary that would have been paid through the Initial Payment Date had payments commenced immediately following the Separation from Service, with the balance paid thereafter on the original schedule. 

(b) Pro-Rated Bonus. The Company will pay, as severance, a lump sum payment under the terms of the annual cash bonus plan in place
for the year in which the Qualifying Termination occurs, equal to the product of (i) the Service Fraction and (ii) the then-current target annual cash bonus (ignoring the effect of any reduction in base salary that forms the basis for Good
Reason in determining the target bonus amount) that the Executive was eligible for under the annual cash bonus plan for that year. This pro-rated bonus payment will be paid on the later of (i) the Initial Payment Date and (ii) the day
immediately prior to the effective date of the Change of Control (such later date, the “Determination Date”). 

(c) COBRA Payments. If the Executive is participating in the Company’s group health insurance plans on the date of the
Qualifying Termination, and timely elects to continue such coverage under COBRA, then the Company will provide the COBRA Continuation Payments, but for up to 18 months, under the same terms and conditions set forth under Section 3(c) above.

 (d) 150% Target Bonus. In addition to the pro-rated bonus described in Section 4(b) above, the Company will pay,
as severance, an amount equal to 150% of the Executive’s then-current target annual cash bonus (ignoring the effect of any reduction in base salary that forms the basis for Good Reason in determining the target bonus amount), payable in equal
installments over the first 18 months following the Separation from Service, on the Company’s normal payroll schedule; provided, however, that no payments will be made until the later of (i) the Initial Payment Date and
(ii) the Determination 

  
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Date, and on such later date, the Company will make a lump sum payment of these target bonus amounts that would have been paid through such date had payments commenced immediately following the
Separation from Service, with the balance paid thereafter on the original schedule. 
 (e) Vesting Acceleration. The
Company will accelerate in full the service-based vesting requirements of all of the Executive’s then-outstanding compensatory equity awards, with such accelerated vesting effective as of the Determination Date. For clarity, this
Section 4(e) does not provide for the waiver of, or deemed satisfaction of, any performance-based vesting requirements applicable to any compensatory equity awards. 
 5. Section 409A. It is intended that all of the benefits provided under the Agreement satisfy, to the greatest extent possible, the exemptions from the application of Section 409A
of the Code and the regulations and other guidance thereunder and any state law of similar effect (collectively, “Section 409A”) provided under Treasury Regulations Sections 1.409A-1(b)(4), 1.409A-1(b)(5) and 1.409A-1(b)(9), and the
Agreement will be construed to the greatest extent possible as consistent with those provisions, taking into account the effect of the status of the benefits under the Prior Agreement on this Agreement. To the extent not so exempt, the Agreement
(and any definitions under the Agreement) will be construed in a manner that complies with Section 409A, and incorporates by reference all required definitions and payment terms. For purposes of Section 409A (including, without limitation,
for purposes of Treasury Regulations Section 1.409A-2(b)(2)(iii)), the Executive’s right to receive any installment payments under the Agreement will be treated as a right to receive a series of separate payments and, accordingly, each
installment payment under the Agreement will at all times be considered a separate and distinct payment. If the Board determines that any of the payments in connection with a Separation from Service constitute “deferred compensation” under
Section 409A, and if the Executive is a “specified employee” of the Company, as such term is defined in Section 409A(a)(2)(B)(i), at the time of his Separation from Service, then, solely to the extent necessary to avoid the
incurrence of the adverse personal tax consequences under Section 409A, the timing of the payments due on a Separation from Service will be delayed as follows: on the earlier to occur of (i) the date that is six months and one day after
the effective date of the Executive’s Separation from Service, and (ii) the date of the Executive’s death (such earlier date, the “Delayed Initial Payment Date”), the Company will (A) pay to the Executive a lump
sum amount equal to the sum of the payments that the Executive would otherwise have received through the Delayed Initial Payment Date if the commencement of the payments had not been delayed pursuant to this paragraph, and (B) commence paying
the balance of the payments in accordance with the applicable payment schedules set forth above. No interest will be due on any amounts so deferred. 
 6. Section 280 - Best After Tax. If any payment or benefit the Executive would receive from the Company or otherwise in connection with a change of control of the Company (a
“Payment”) would (a) constitute a “parachute payment” within the meaning of Section 280G of the Code, and, (b) but for this sentence, be subject to the excise tax imposed by Section 4999 of the Code
(the “Excise Tax”), then such Payment will be equal to the Reduced Amount. The “Reduced Amount” will be either (a) the largest portion of the Payment that would result in no portion of the Payment being subject
to the Excise Tax, or (b) the largest portion, up to and including the total, of the Payment, whichever amount, after taking into account all applicable federal, state, provincial, foreign and local employment taxes, income taxes, and the
Excise Tax (all computed at the highest applicable marginal rate), results in the Executive’s receipt, on an after-tax basis, of the greatest economic benefit (as determined in accordance with the cancellation/reduction order below)
notwithstanding that all or some portion of the Payment may be subject to the Excise Tax. If a reduction in payments or benefits constituting “parachute payments” is necessary so that the Payment equals the Reduced Amount, reduction will
occur in the following order: (1) reduction of cash payments; (2) cancellation of accelerated vesting of stock awards other than stock 

  
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options (in the reverse order of the date of grant); (3) cancellation of accelerated vesting of stock options (in reverse order of exercise price, that is, cancelling the highest priced
options first); and (4) reduction of other benefits paid to the Executive. Within any such category of Payments (that is, (1), (2), (3) or (4)), a reduction will occur first with respect to amounts that are not “deferred
compensation” within the meaning of Section 409A of the Code and then with respect to amounts that are. The Executive has no rights to receive any Excise Tax gross up on any Payments. The Company will select a reputable third-party
professional firm to make all determinations required to be made under this Section 6. The Company will bear all reasonable expenses with respect to the determinations by such firm required to be made hereunder. 

7. Duty of Loyalty & Confidentiality. 
 (a) Confidentiality Agreement. The Executive acknowledges and agrees that at all times during his employment with the Company he has been in compliance with, and he represents that he will continue
to comply with, the terms of the Confidentiality Agreement. The Executive understands and agrees that as part of the consideration for the payments by the Company to the Executive under this Agreement, the Executive must remain in compliance with
the terms of the Confidentiality Agreement following his Qualifying Termination, including, but not limited to, the obligations of confidentiality and non-solicitation, as well as any comparable duties (such as the duty of loyalty) under applicable
law. 
 (b) Non-Disparagement. The Executive understands and agrees that as part of the consideration for the payments by
the Company to the Executive under this Agreement, at all times during the Executive’s employment and during any period in which he is receiving severance benefits following a Qualifying Termination, the Executive will not take any actions to
disrupt the Company’s business or tarnish the Company’s reputation. Without limitation, the Executive will not (i) disparage the Company or its officers, directors, employees, stockholders, parents, subsidiaries, affiliates and
agents, including, but not limited to, statements that may be harmful to its or their business, business reputation or personal reputation, or (ii) interfere or attempt to interfere with any existing relationship between the Company and any
Company customer or supplier. Nothing in this paragraph is intended to restrain the Executive in any manner from (x) engaging in any lawful profession, trade or business of any kind, (y) seeking legal counsel or (z) making truthful
statements as required by law. 
 (c) Enforcement. The Executive acknowledges and agrees that the Company’s remedies
at law for a breach or threatened breach of any of the provisions of this Section 7 (including any breach of the Confidentiality Agreement, collectively, the “Covenants”) would be inadequate and, in recognition of this fact,
Executive agrees that, in the event of such a breach or threatened breach, in addition to any remedies at law, the Company will be entitled to obtain equitable relief in the form of specific performance, temporary restraining order, temporary or
permanent injunction or any other equitable remedy which may then be available. In addition, the Company will be entitled to immediately cease paying any amounts remaining due under this Agreement. It is expressly understood and agreed that although
the Executive and the Company consider the Covenants to be reasonable, if a judicial determination is made by a court of competent jurisdiction that the time or territory or any other restriction contained in this Agreement is an unenforceable
restriction against Executive, the Covenants will not be rendered void but will be deemed amended to apply as to such maximum time and territory and to such maximum extent as such court may judicially determine or indicate to be enforceable.
Alternatively, if any court of competent jurisdiction finds that any of the Covenants is unenforceable, and such Covenant cannot be amended so as to make it enforceable, such finding will not affect the enforceability of the remainder of the
Covenants. In any action, suit or proceeding to enforce the Covenants, the prevailing party will be entitled to an award of its or his reasonable attorneys’ fees and costs incurred. 

  
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 8. Definition of Terms. 

(a) “Cause” will mean: (i) any act of personal dishonesty taken by the Executive in connection with his
responsibilities as an employee and intended to result in substantial personal enrichment of the Executive; (ii) the Executive’s conviction of or plea of nolo contendre to a felony; (iii) a willful act by the Executive that
constitutes gross misconduct and that is injurious to the Company; or (iv) following delivery to the Executive of a written demand for performance from the Company that describes the basis for the Company’s belief that the Executive has
not substantially performed his duties, continued violations by the Executive of the Executive’s obligations to the Company that are demonstrably willful and deliberate on the Executive’s part. 

(b) “Change of Control” has the meaning of “Change in Control” set forth in the Company’s 2005 Equity
Incentive Plan, as of the date of this Agreement, except that if required for compliance with Section 409A, in no event will a Change of Control be deemed to have occurred if such transaction is not also a “change in the ownership or
effective control of” the Company or “a change in the ownership of a substantial portion of the assets of” the Company as determined under Treasury Regulation Section 1.409A-3(i)(5) (without regard to any alternative definition
thereunder). 
 (c) “Good Reason” will mean any of the following conditions arising without the
Executive’s prior written consent: 
 (i) a material reduction in the Executive’s annual base compensation;

 (ii) a material diminution in the Executive’s authority, duties, or responsibilities but only if such diminution happens
during the Change of Control Period; or 
 (iii) a requirement that the Executive relocate his principal work location to a
location that increases the Executive’s one-way commute by more than forty (40) miles; 
 provided, however, that in any case,
the Executive must (A) provide the Company with written notice setting forth with specificity the occurrence of such act or event within thirty (30) days after such act or event first occurs, (B) allow the Company thirty
(30) days to cure such act or event from the date it receives such notice, and (C) if the Company does not cure such act or event within such period, the Executive’s resignation from all positions he then holds is effective not later
than sixty (60) days after the conclusion of such cure period. Neither entry into this Agreement, nor the occurrence of the changes to the terms of the Executive’s employment set forth herein, will provide a basis for resignation for Good
Reason. 
 9. Successors. 
 (a) Company’s Successors. This Agreement will be binding upon any surviving entity resulting from a Change of Control and upon any other person who is a successor by merger, acquisition,
consolidation or otherwise to the business formerly carried on by the Company without regard to whether or not such person or entity actively assumes the obligations hereunder. 

(b) Executive’s Successors. The Executive may not assign his obligations hereunder. The rights of the Executive hereunder
will inure to the benefit of, and be enforceable by, the Executive’s personal or legal representatives, executors, administrators, successors, heirs, distributees, devisees and legatees. 

  
 6 

 10. Notice. For the purpose of this Agreement, notices and all other communications provided
for in this Agreement must be given in writing and will be deemed to have been duly given if (i) delivered personally, (ii) delivered by overnight courier service, (iii) mailed by registered mail, return receipt requested, postage
prepaid, or (iv) sent via facsimile or email (with the receipt function turned on) to the Company’s facsimile numbers and email addresses. Notices sent by personal delivery, registered mail, or overnight courier will be deemed given when
delivered and notices sent by facsimile transmission or email will be deemed given upon the sender’s receipt of confirmation of complete transmission. 
 11. Offsets. The Company will reduce the Executive’s benefits under this Agreement by any statutory severance obligations or other contractual severance benefits, obligations for pay in
lieu of notice, and any other similar benefits payable to the Executive by the Company (or any successor thereto) that are due in connection with the Executive’s Qualifying Termination and that are in the same form as the benefits provided
under this Agreement (e.g., equity award vesting credit). Without limitation, this reduction includes a reduction for any benefits required pursuant to (a) any applicable legal requirement, including, without limitation, the Worker Adjustment
and Retraining Notification Act (the “WARN Act”), (b) a written employment, severance or equity award agreement with the Company, (c) any Company policy or practice providing for the Executive to remain on the payroll for
a limited period of time after being given notice of termination, and (d) any required salary continuation, notice pay, statutory severance payment, or other payments either required by local law, or owed pursuant to a collective labor
agreement, as a result of the termination of the Executive’s employment. The benefits provided under this Agreement are intended to satisfy, to the greatest extent possible, and not to provide benefits duplicative of, any and all statutory,
contractual and collective agreement obligations of the Company. Reductions may be applied on a retroactive basis, with benefits previously provided being recharacterized as benefits pursuant to the Company’s statutory or other contractual
obligations. If the Executive is indebted to the Company on the effective date of his Qualifying Termination, the Company reserves the right to offset the payment of any severance benefits under this Agreement by the amount of such indebtedness.
Such offset will be made in accordance with all applicable laws. 
 12. Miscellaneous Provisions. 

(a) No Duty to Mitigate. Except with respect to COBRA benefits, the Executive is not required to mitigate the amount of any
payment contemplated by this Agreement, nor will any such payment be reduced by any compensation that the Executive may receive from any other source. 
 (b) Amendment; Waiver. No provision of this Agreement will be amended, modified, waived or discharged unless the amendment, modification, waiver or discharge is agreed to in writing by the
adversely affected party. No waiver by either party of any breach of, or of compliance with, any condition or provision of this Agreement by the other party will be considered a waiver of any other condition or provision or of the same condition or
provision at another time. 
 (c) Whole Agreement. No agreements, representations or understandings (whether oral or
written and whether express or implied) that are not expressly set forth in this Agreement have been made or entered into by either party with respect to the subject matter hereof. This Agreement represents the entire understanding of the parties
hereto with respect to the subject matter hereof and supersedes all prior arrangements and understandings regarding same, including the Prior Agreement. 
 (d) Choice of Law. The validity, interpretation, construction and performance of this Agreement will be governed by the laws of the State of California as applied to agreements entered into among
California residents to be performed entirely within California, without regard to conflict of laws rules. 

  
 7 

 (e) Severability. The invalidity or unenforceability of any provision or provisions
of this Agreement will not affect the validity or enforceability of any other provision hereof, which will remain in full force and effect. 
 (f) Counterparts. This Agreement may be executed in counterparts, each of which will be deemed an original, but all of which together will constitute one and the same instrument. 

IN WITNESS WHEREOF, each of the parties has executed this Agreement, in the case of the Company by its duly authorized officer, as of the
day and year set forth above. 
  

							
	COMPANY:	 		 	XENOPORT, INC.
				
		 		 	By:	 	 /s/ Ronald W. Barrett

		 		 		 	Ronald W. Barrett, PhD
			
	EXECUTIVE:	 		 	KENNETH C. CUNDY, PHD
			
		 		 	 /s/ Kenneth C. Cundy

  
 8 

 EXHIBIT A 

GENERAL RELEASE 
 THIS
GENERAL RELEASE, dated as of             , 20    (this “Agreement”), is entered into by and between Kenneth C. Cundy, PhD
(“Executive”) and XenoPort, Inc. (the “Company”). The Executive’s employment with the Company has terminated effective             ,
20    . As set forth in the Amended & Restated Severance Rights Agreement between the Executive and the Company dated December 20, 2012, Executive and the Company hereby agree as follows: 

1. Executive will be provided severance pay and other benefits (the “Severance Benefits”) set forth in Section
    of the Amended & Restated Severance Rights Agreement, subject to his satisfaction of the conditions for payment set forth therein and in this Agreement. 

2. Executive, for and on behalf of himself and Executive’s heirs, successors, agents, representatives, executors and assigns,
hereby waives and releases the Company and its affiliates, and their parents, subsidiaries, successors, predecessors and affiliates, and their partners, members, directors, officers, employees, stockholders, shareholders, agents, attorneys,
predecessors, insurers, affiliates and assigns (collectively, the “Company Releasees”), from any and all claims, liabilities and obligations, both known and unknown (each, a “Claim”) that arise out of or are in any
way related to events, acts, conduct, or omissions occurring at any time prior to and including the date Executive signs this Agreement. This general release includes, but is not limited to: (a) all claims arising out of or in any way related
to Executive’s employment with the Company and its affiliates, or their affiliates, or the termination of that employment; (b) all claims related to Executive’s compensation or benefits, including salary, bonuses, commissions,
vacation pay, expense reimbursements, severance pay, fringe benefits, stock, stock options, or any other ownership interests in the Company and its affiliates, or their affiliates; (c) all claims for breach of contract, wrongful termination,
and breach of the implied covenant of good faith and fair dealing; (d) all tort claims, including claims for fraud, defamation, emotional distress, and discharge in violation of public policy; and (e) all federal, state, provincial and
local statutory claims, including claims for discrimination, harassment, retaliation, attorneys’ fees, or other claims arising under the federal Civil Rights Act of 1964 (as amended), the federal Americans with Disabilities Act of 1990 (as
amended), the federal Age Discrimination in Employment Act (as amended) (“ADEA”), the federal Employee Retirement Income Security Act of 1974 (as amended), and the California Fair Employment and Housing Act (as amended). 

3. By signing this Agreement, Executive acknowledges that Executive intends to waive and release any rights known or unknown
Executive may have against the Company Releasees under these and any other laws; provided that, Executive does not waive or release Claims (i) with respect to the right to enforce this Agreement or those provisions of the Amended &
Restated Severance Rights Agreement that expressly survive the termination of Executive’s employment with the Company, (ii) with respect to any vested right Executive may have under any employee pension or welfare benefit plan of the
Company, or (iii) any rights to indemnification preserved under any applicable indemnification agreement, any D&O insurance policy applicable to Executive and/or the Company’s certificates of incorporation, charter and by-laws, or
(iv) with respect to any claims that cannot legally be waived. 
 4. Executive acknowledges that Executive has been
given twenty-one (21) days from the date of receipt of this Agreement to consider all of the provisions of the Agreement and, to the extent he has not used the entire 21-day period prior to executing the Agreement, he does hereby knowingly and

  
 A-1

 
voluntarily waive the remainder of said 21-day period. EXECUTIVE FURTHER ACKNOWLEDGES THAT HE HAS READ THIS AGREEMENT CAREFULLY, HAS BEEN ADVISED BY THE COMPANY TO CONSULT AN ATTORNEY, AND FULLY
UNDERSTANDS THAT BY SIGNING BELOW HE IS GIVING UP CERTAIN RIGHTS WHICH HE MAY HAVE TO SUE OR ASSERT A CLAIM AGAINST ANY OF THE COMPANY RELEASEES, AS DESCRIBED HEREIN AND THE OTHER PROVISIONS HEREOF. EXECUTIVE ACKNOWLEDGES THAT HE HAS NOT BEEN FORCED
OR PRESSURED IN ANY MANNER WHATSOEVER TO SIGN THIS AGREEMENT AND EXECUTIVE AGREES TO ALL OF ITS TERMS VOLUNTARILY. 
 5.
Executive will have seven (7) days from the date of Executive’s execution of this Agreement to revoke the release, including with respect to all claims referred to herein (including, without limitation, any and all claims arising under
ADEA). If Executive revokes the Agreement, Executive will be deemed not to have accepted the terms of this Agreement. 
 6.
Executive acknowledges having read and understood Section 1542 of the California Civil Code which reads as follows: “A general release does not extend to claims which the creditor does not know or suspect to exist in his or her
favor at the time of executing the release, which if known by him or her must have materially affected his or her settlement with the debtor.” Executive hereby expressly waives and relinquishes all rights and benefits under that section and
any law of any jurisdiction of similar effect with respect to Executive’s release of any claims hereunder. 
 7.
Executive hereby represents that Executive has been paid all compensation owed and for all hours worked; has received all the leave and leave benefits and protections for which Executive is eligible pursuant to the Family and Medical Leave Act,
the California Family Rights Act, or otherwise; and has not suffered any on-the-job injury for which Executive has not already filed a workers’ compensation claim. 
 IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the date first above written. 
  

	
	XENOPORT, INC.
	
	  

	By:
	
	EXECUTIVE
	
	  

	KENNETH C. CUNDY, PHD

  
 A-2

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