Document:

EX-4.7

 Exhibit 4.7 

FIRST SUPPLEMENTAL INDENTURE dated as of March 21, 2014, among GlaxoSmithKline Capital plc, a public limited company incorporated under the
laws of England and Wales (the “Company”), GlaxoSmithKline plc, a public limited company incorporated under the laws of England and Wales, as guarantor (the “Guarantor”), and Law Debenture Trust Company of New York (as successor
to Citibank, N.A.), a company duly organized and existing under the laws of the State of New York (the “Trustee”). 
 RECITALS

 WHEREAS, the Company, the Guarantor and Citibank, N.A., a national banking association duly organized and existing under the laws of
the United States (the “Former Trustee”), entered into an indenture, dated as of April 6, 2004 (the “Indenture”), relating to the issuance from time to time by the Company of its Securities; 

WHEREAS, the Company, the Guarantor, the Former Trustee and the Trustee entered into an Instrument of Resignation, Appointment and Acceptance,
dated as of January 7, 2008, whereby the Former Trustee resigned as trustee, and the Trustee was appointed, and accepted its appointment, as trustee under the Indenture; 

WHEREAS, Section 10.01 of the Indenture provides, among other things, that a supplemental indenture may be entered into by the Company,
the Guarantor and the Trustee, without notice to or the consent of any Holders, (i) to establish the terms of Securities of any series; and/or (ii) to make any change that does not materially and adversely affect the rights of any Holder
of Securities outstanding prior to the date of such supplemental indenture; 
 WHEREAS, the Company and the Guarantor have requested the
Trustee to join with it in the execution and delivery of this first supplemental indenture (the “First Supplemental Indenture”) in order to supplement and amend the Indenture, solely with respect to Securities issued on or after the date
hereof, to: (1) amend certain redemption provisions; (2) amend certain covenants of the Company and the Guarantor; and (3) amend the definition of “Event of Default”; in no event will the provisions of this First
Supplemental Indenture affect the interests of the Holders of Securities of any series outstanding prior to the date of this First Supplemental Indenture in any respect; 

WHEREAS, the Company and the Guarantor have determined that this First Supplemental Indenture complies with said Section 10.01, does not
affect the interests of any Holders of Securities outstanding prior to the date of this First Supplemental Indenture and does not require notice to or the consent of any Holders; and 

WHEREAS, the Company and the Guarantor represent and warrant that all things necessary to make this First Supplemental Indenture a valid
agreement of the Company, the Guarantor and the Trustee, in accordance with the terms of the Indenture, and a valid amendment of and supplement to the Indenture have been done; 

NOW, THEREFORE, THIS FIRST SUPPLEMENTAL INDENTURE WITNESSETH: 

 For and in consideration of the premises and the mutual covenants contained herein and in the
Indenture and for other good and valuable consideration, the receipt and sufficiency of which are herein acknowledged, the Company, the Guarantor and the Trustee hereby agree, for the equal and ratable benefit of the Holders, as follows: 

ARTICLE I 
 DEFINITIONS

 SECTION 1.01 Defined Terms. All capitalized terms used but not defined herein shall have the meanings ascribed to such terms in
the Indenture, as supplemented and amended hereby. All definitions in the Indenture shall be read in a manner consistent with the terms of this First Supplemental Indenture. 

SECTION 1.02 Additional Definitions. 

“Additional Amounts” has the meaning specified in Section 2.02 hereof. 

“EDGAR System” means the EDGAR filing system of the Commission and the rules and regulations pertaining thereto promulgated by the Commission in
Regulation S-T under the Securities Act and the Exchange Act, in each case as the same may be amended or succeeded from time to time (and without regard to format). 

“Taxes” has the meaning specified in Section 2.02 hereof. 

ARTICLE II 
 AMENDMENTS
TO THE INDENTURE 
 SECTION 2.01 Amendments to Section 3.01 Relating to Redemption. Section 3.01 of the Indenture is
amended, with respect to Securities outstanding under series created on or after the date hereof, to read as follows: 

“Section 3.01 Applicability of Article. Securities of any series that are redeemable before their maturity shall be
redeemable in accordance with their terms and (except as otherwise specified as contemplated by Section 2.03 of the Indenture for Securities of any series) in accordance with this Article Three. The provisions of this Article Three shall be
applicable to the Securities of any series, in whole but not in part, if, with respect to such series: 
 (a) the Company
(or, if applicable, the Guarantor) determines that, as a result of any change in or amendment to the laws or any regulations or rulings promulgated thereunder of the United Kingdom (or of any political subdivision or taxing authority thereof), or
any change in the application or official interpretation of such laws, regulations or rulings, or any change in the application or official interpretation of, or any execution of or amendment to, any treaty or treaties affecting taxation to which
any such jurisdiction is a party, which change, execution or amendment becomes effective on or after the issue date or such other date specified in the Securities of such series, 

 (i) the Company (or, if applicable, the Guarantor) would be required to pay
Additional Amounts (as defined in Section 4.05) with respect to such series of Securities on the next succeeding interest payment date and the payment of such Additional Amounts cannot be avoided by the use of reasonable measures available to
the Company or the Guarantor, or 
 (ii) withholding tax has been or would be required to be withheld with respect to
interest income received or receivable by the Company directly from the Guarantor (or any affiliate) and such withholding tax obligation cannot be avoided by the use of reasonable measures available to the Company or the Guarantor (or any
affiliate); or 
 (b) the Company (or, if applicable, the Guarantor) determines, based upon an opinion of independent counsel
of recognized standing that, as a result of any action taken by any legislative body of, taxing authority of, or any action brought in a court of competent jurisdiction, in the United Kingdom (or of any political subdivision or taxing authority
thereof) (whether or not such action was taken or brought with respect to the Company or the Guarantor), which action is taken or brought on or after the issue date or such other date specified in the Securities of such series, there is a
substantial probability that the circumstances described in subsection (a) above would exist; provided, however, that no such notice of redemption may be given earlier than 90 days prior to the earliest date on which the Company would be
obligated to pay such Additional Amounts. The Company or the Guarantor will also pay to each Holder, or make available for payment to each such Holder, on the redemption date any Additional Amounts resulting from the payment of such redemption
price.” 
 SECTION 2.02 Amendments to Section 4.05 Relating to Payment of Additional Amounts. Section 4.05 of the
Indenture is amended, with respect to Securities outstanding under series created on or after the date hereof, to read as follows: 

“Section 4.05 Payment of Additional Amounts. All payments of Principal and interest in respect of the Securities shall be
free and clear of and without withholding or deduction for or on account of any present or future tax, duty, levy, impost, assessment or other governmental charge of any nature whatsoever imposed or levied by or on behalf of the government of the
United Kingdom or of any territory of the United Kingdom or by any authority or agency therein or thereof having the power to tax (collectively, “Taxes”), except to the extent such Taxes are required to be withheld or deducted by law or by
the interpretation or administration thereof. If either the Company or the Guarantor is so required to withhold or deduct any amount for or on account of Taxes from any payment made in respect of the Securities, the Company or the Guarantor, as the
case may be, shall pay such additional amounts (“Additional Amounts”) as may be necessary such that the net amount received by each Holder (including such Additional Amounts) after such withholding or deduction shall not be less than the
amount such Holder would have received if the Taxes had not been withheld or deducted; provided that no Additional Amounts will be payable with respect to Taxes: 

  
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 (a) that would not have been imposed but for the existence of any present or
former connection between such Holder or beneficial owner of the Securities (or between a fiduciary, settlor, beneficiary, member or shareholder of, or possessor of a power over, such Holder or beneficial owner, if such Holder or beneficial owner is
an estate, trust, partnership or corporation) and the United Kingdom or any political subdivision or territory or possession thereof or therein or area subject to its jurisdiction, including, without limitation, such Holder or beneficial owner (or
such fiduciary, settlor, beneficiary, member, shareholder or possessor) being or having been a citizen or resident thereof or treated as a resident thereof or domiciled thereof or a national thereof or being or having been present or engaged in
trade or business therein or having or having had a permanent establishment therein; 
 (b) that are estate, inheritance,
gift, sales, transfer, personal property, wealth or similar taxes, duties, assessments or other governmental charges; 
 (c)
that are payable other than by withholding from payments of Principal of or interest on the Securities; 
 (d) that would not
have been imposed but for the failure of the applicable recipient of such payment to comply with any certification, identification, information, documentation or other reporting requirement to the extent such compliance is required by applicable law
or administrative practice or an applicable treaty as a precondition to exemption from, or reduction in, the rate of deduction or withholding of such Taxes; 

(e) that would not have been imposed but for the presentation of a Security (where presentation is required) for payment on a
date more than 30 days after the date on which such payment became due and payable or the date on which payment thereof was duly provided for, whichever occurred later; 

(f) that are imposed on a payment to an individual and are required to be made pursuant to European Council Directive
2003/48/EC or any other Directive implementing the conclusions of the ECOFIN Council meeting of November 26-27, 2000 on the taxation of savings income, or any law implementing or complying with, or introduced in order to conform to, such
Directive; 
 (g) that would not have been imposed if presentation for payment of the relevant Securities had been made to a
Paying Agent other than the Paying Agent to which the presentation was made; 
 (h) that would not have been imposed but for
a failure by the Holder or beneficial owner (or any financial institution through which the Holder or beneficial owner holds any Security through which payment on the Security is made) to comply with any certification, information, identification,
documentation or other reporting requirements (including entering into and 

  
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complying with an agreement with the U.S. Internal Revenue Service or any other governmental authority) imposed pursuant to Sections 1471 through 1474 of the U.S. Internal Revenue Code as in
effect on the date of issuance of the Notes or any successor or amended version of such provisions, any agreement entered into pursuant to Section 1471(b) of the U.S. Internal Revenue Code, or any fiscal or regulatory legislation, rules or
practices adopted pursuant to any intergovernmental agreement entered into in connection with the implementation of such Sections of the U.S. Internal Revenue Code (or any law implementing such an intergovernmental agreement); or 

(i) any combination of the foregoing clauses (a) through (h); 

nor shall Additional Amounts be paid with respect to any payment of the Principal of or interest on any Security to any such Holder who is a
fiduciary or a partnership or a beneficial owner who is other than the sole beneficial owner of such payment to the extent a beneficiary or settlor with respect to such fiduciary or a member of such partnership or a beneficial owner would not have
been entitled to such Additional Amounts had it been the Holder of the Security. 
 The Company shall maintain, in respect of
Securities of each series outstanding, at least one Paying Agent located outside the United Kingdom. In the event that a Paying Agent with respect to Securities of a particular series is maintained in any member state of the European Union, the
Company shall maintain a Paying Agent in at least one member state that will not be obliged to withhold or deduct taxes pursuant to any law implementing European Council Directive 2003/48/EC or any other Directive implementing the conclusions of the
ECOFIN Council meeting of November 26-27, 2000 on the taxation of savings income, provided there is at least one member state that does not require a paying agent to withhold or deduct pursuant to such Directive. 

The obligation of the Company or the Guarantor, as the case may be, to pay Additional Amounts if and when due will survive the
termination of this Indenture and the payment of all amounts in respect of the Securities.” 
 SECTION 2.03 Amendments to
Section 4.08 Relating to Reports by the Company and the Guarantor. Paragraph (a) of Section 4.08 of the Indenture is amended, with respect to Securities outstanding under series created on or after the date hereof, to read as follows:

 “(a) file with the Trustee, within 15 days after the Company or the Guarantor, as the case may be, is required to file the same with
the Commission, copies of the annual reports and of the information, documents and other reports (or copies of such portions of any of the foregoing as the Commission may from time to time by rules and regulations prescribe) which the Company or the
Guarantor may be required to file with the Commission pursuant to Section 13 or Section 15(d) of the Exchange Act; or, if the Company or the Guarantor is not required to file information, documents or reports pursuant to either of such
Sections, then it will file with the Trustee, in accordance with rules and regulations prescribed from time to time by the Commission, such of the supplementary and periodic information, documents and reports which may be required

  
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pursuant to Section 13 of the Exchange Act in respect of a security listed and registered on a national securities exchange as may be prescribed from time to time in such rules and
regulations; provided that reports, information and documents filed by the Company or the Guarantor with the Commission via the EDGAR System will be deemed filed with the Trustee for purposes of this Section 4.08 as of the time that such
reports, information and documents are filed via the EDGAR System;”. 
 SECTION 2.04 Amendments to Section 7.01 Relating to
Events of Default. 
 (a) Paragraph (c) of Section 7.01 of the Indenture is amended, with respect to Securities outstanding under
series created on or after the date hereof, to replace the number “60” with “90.” 
 (b) Paragraph (d) of
Section 7.01 of the Indenture is amended, with respect to Securities outstanding under series created on or after the date hereof, to read as follows: 

“(d) default under any bond, debenture, note or other evidence of indebtedness for money borrowed of the Company or the
Guarantor (not including any indebtedness for which recourse is limited to property purchased) having in any particular case an aggregate outstanding principal amount in excess of £100,000,000 (or its equivalent in any other currency), whether
such indebtedness now exists or shall hereafter be created, which default shall have resulted in such indebtedness becoming or being accelerated and declared due and payable prior to the date on which it would otherwise have become due and payable,
without such acceleration having been rescinded or annulled or such indebtedness having been discharged; provided that there shall not be deemed to be an Event of Default if such acceleration is rescinded or annulled or such payment is made within
10 days after there has been given to the Company and the Guarantor by the Trustee or to the Company, the Guarantor and the Trustee by the Holders of 25% or more in aggregate principal amount of the Securities of such series a written notice
specifying such default and requiring it to be remedied and stating that such notice is a “Notice of Default” hereunder;”. 

ARTICLE III 
 GENERAL
PROVISIONS 
 SECTION 3.01 Trustee Makes No Representation. The recitals contained herein shall be taken as the statements of the
Company and the Guarantor, and the Trustee assumes no responsibility for the correctness of same. The Trustee makes no representation as to the validity of this First Supplemental Indenture. 

SECTION 3.02 Effect of the First Supplemental Indenture. This First Supplemental Indenture supplements the Indenture and shall be a part,
and subject to all the terms, thereof. The Indenture, as supplemented and amended by this First Supplemental Indenture, is in all respects ratified and confirmed, and the Indenture and the First Supplemental Indenture shall be read, taken and
construed as one and the same instrument; provided, however, that any provision in this First Supplemental Indenture which conflicts with any corresponding provision in the Indenture shall replace such conflicting terms in the Indenture in their
entirety, to the extent that such terms relate to any Securities issued hereafter. All provisions included in this First Supplemental Indenture supersede any conflicting provisions included in the Indenture unless not permitted by law. 

  
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 SECTION 3.03 Counterparts. This First Supplemental Indenture may be executed in any number
of counterparts, each of which so executed shall be deemed to be an original, but all such counterparts shall together constitute but one and the same instrument. 

SECTION 3.04 Trust Indenture Act. The Company and the Guarantor hereby certify that this First Supplemental Indenture conforms to the
current requirements of the Trust Indenture Act. 
 SECTION 3.05 Governing Law; Waiver of Jury Trial. The laws of the State of New York
shall govern this First Supplemental Indenture. Each of the Company, the Guarantor and the Trustee hereby irrevocably waives, to the fullest extent permitted by applicable law, any and all right to trial by jury in any legal proceeding arising out
of or relating to this First Supplemental Indenture. 

  
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 IN WITNESS WHEREOF, the parties hereto have caused this First Supplemental Indenture to be duly
executed, all as of the date first written above. 
  

			
	 GLAXOSMITHKLINE CAPITAL PLC,
 as
Issuer

		
	 By:
	 	 /s/ Simon Dingemans

		 	 Name: Simon Dingemans

		 	 Title: Director

	
	 GLAXOSMITHKLINE PLC,
 as
Guarantor

		
	 By:
	 	 /s/ Simon Dingemans

		 	 Name: Simon Dingemans

		 	 Title: Chief Financial Officer

	
	 LAW DEBENTURE TRUST COMPANY OF NEW YORK,

as Trustee

		
	 By:
	 	 /s/ James Heaney

		 	 Name: James Heaney

		 	 Title: Managing DirectorEX-4.8

 Exhibit 4.8 

FORM OF NOTE 
 This
Security is in global form within the meaning of the Indenture hereinafter referred to and is registered in the name of The Depository Trust Company, a New York corporation (“DTC”), or a nominee of DTC, which may be treated by the
Company, the Trustee and any agent thereof as owner and holder of this Security for all purposes. 
 Unless this certificate is
presented by an authorized representative of DTC to the Company or its agent for registration of transfer, exchange or payment, and any certificate issued is registered in the name of Cede & Co. or in such other name as is requested by an
authorized representative of DTC (and any payment is made to Cede & Co. or to such other entity as is requested by an authorized representative of DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS
WRONGFUL inasmuch as the registered owner hereof, Cede & Co., has an interest herein. 
 Unless and until it is exchanged in
whole or in part for Securities in definitive form in the limited circumstances referred to in the Indenture, this global Security may not be transferred except as a whole by DTC to a nominee of DTC or by a nominee of DTC to DTC or another nominee
of DTC or by DTC or any such nominee to a successor depositary or a nominee of such successor depositary. 
  

					
	Registered No. 1	  	Principal Amount: $	[	—] 
	CUSIP No. [—]	  			

 GLAXOSMITHKLINE PLC 

[ Title of Securities ] 

GlaxoSmithKline plc, a public limited company incorporated under the laws of England and Wales (hereinafter called the
“Company,” which term shall include any successor entity under the Indenture), for value received, hereby promises to pay to Cede & Co., as nominee for DTC, or registered assigns, upon presentation, the principal sum of
[—] ($[—]) on [—] and to pay
interest thereon from [—] or from the most recent interest payment date to which interest has been paid or duly provided for, semi-annually in arrears on [—] and [—] in each year, commencing [—], at
the rate of [—]% per annum, until the entire principal hereof is paid or made available for payment. 

The interest so payable, and punctually paid or duly provided for on any interest payment date will, as provided in the Indenture, be paid to
the Person in whose name this Security is registered at the close of business on the Record Date for such interest, which shall be [—] or [—] (whether or not a Business Day), as the case may be, next preceding such interest payment date. Any such interest not so punctually paid or duly provided for shall forthwith cease to be
payable to the Holder on such Record Date, and may either be paid to the Person in whose name this Security is registered at the close of business on a special record date for the payment of defaulted interest to be fixed by the Trustee, notice
whereof shall be given to Holders of Securities of this series at least 15 days prior to such special record date, or may be paid at any time in any other lawful manner not inconsistent with the requirements of any securities exchange on which
the Securities may be listed, and upon such notice as may be required by such exchange, all as more fully provided in the Indenture. 

Payment of the Principal of and interest on and any Additional Amounts in respect of this global Security will be paid to DTC for the purpose
of permitting DTC to credit the principal and interest received by it in respect of this global Security to the accounts of the beneficial owners thereof; provided, however, that if this Security is not a global Security,
payment of the Principal of, interest on and Additional Amounts, if any, in respect of this Security will be made at the office or agency of the Trustee in The City of New York, or elsewhere as provided in the Indenture, in such coin or currency of
the United States of America as at the time of payment is legal tender for payment of public and private debts; and provided, further, that at the option of the Company payment of interest may be made by (a) check mailed
to the address of the Person entitled thereto as such address shall appear in the Security Register or (b) transfer to an account of the Person entitled thereto located inside the United States. 

Additional provisions of this Security are set forth following the signature page hereof, which provisions shall for all purposes have the
same effect as if set forth at this place. 
 Unless the certificate of authentication hereon has been executed by or on behalf of the
Trustee referred to on the reverse hereof by manual signature, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose. 

 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed this [—]th day of [—]. 

 

			
	GLAXOSMITHKLINE PLC
		
	By:	 	  

	Name:	 	
	Title:	 	
		
	By:	 	  

	Name:	 	
	Title:	 	

 TRUSTEE’S CERTIFICATE OF AUTHENTICATION 

This is one or all of the Securities of the series designated “[—]% Notes due
[—]” pursuant to the within-mentioned Indenture. 
  

			
	LAW DEBENTURE TRUST COMPANY OF NEW YORK, as Trustee
		
	By:	 	  

		 	Authorized Signatory

  
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 [—]% Notes due [—] 
 This Security is one or all of a duly authorized issue of securities of
the Company (herein called the “Securities”) issued and to be issued in one or more series under an Indenture, dated as of March 4, 2008 (herein called the “Indenture”), between the Company and Law Debenture
Trust Company of New York, as trustee (herein called the “Trustee”, which term includes any successor trustee under the Indenture), to which Indenture and all indentures supplemental thereto reference is hereby made for a statement
of the respective rights, limitation of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be, authenticated and delivered. This Security
is one or all of the series designated as the “[—]% Notes due [—].” 

As provided in and subject to the provisions of the Indenture, the Securities in this series are redeemable in whole but not in part, at the
discretion of the Company, if: (a) the Company determines that as a result of any change in or amendment to the laws or any regulations or rulings promulgated thereunder of the United Kingdom (or of any political subdivision or taxing authority
thereof), or any change in the application or official interpretation of such laws, regulations or rulings, or any change in the application or official interpretation of, or any execution of or amendment to, any treaty or treaties affecting
taxation to which any such jurisdiction is a party, the Company would be required to pay Additional Amounts with respect to such series of Securities on the next succeeding interest payment date and the payment of such Additional Amounts cannot be
avoided by the use of reasonable measures available to the Company, or withholding tax has been or would be required to be withheld with respect to interest income received or receivable by the Company directly from any affiliate and such
withholding tax obligation cannot be avoided by the use of reasonable measures available to the Company (or any affiliate) or (b) the Company determines, based upon an opinion of independent counsel of recognized standing that, as a result of
any action taken by any legislative body of, taxing authority of, or any action brought in a court of competent jurisdiction in, the United Kingdom (or any political subdivision or taxing authority thereof) there is a substantial probability that
the circumstances described in subsection (a) above would exist; provided, however, that no such notice of redemption may be given earlier than 90 days prior to the earliest date on which the Company would be obligated
to pay such Additional Amounts. The Company will also pay to each Holder, or make available for payment to each such Holder, on the redemption date any Additional Amounts resulting from the payment of such redemption price. 

In the event of a redemption as described in the preceding paragraph, notice of such redemption to the Holders of Securities of any series to
be redeemed in whole but not in part at the option of the Company shall be given by mailing notice of such redemption by first class mail, postage prepaid, at least 30 days and not more than 60 days prior to the date fixed for redemption
to such Holders of Securities of such series at their last addresses as they shall appear upon the Security Register of the Company. 
 The
Indenture contains provisions for defeasance of (a) the entire indebtedness of this Security and (b) certain restrictive covenants and the related defaults and Events of Default applicable to the Company, in each case, upon compliance by
the Company with certain conditions set forth in the Indenture, which provisions apply to this Security. 
 If an Event of Default with
respect to the Securities of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in the manner and with the effect provided in the Indenture. 

As provided in and subject to the provisions of the Indenture, the Holder of this Security shall not have the right to institute any
proceeding with respect to the Indenture or for the appointment of a receiver or trustee or for any other remedy thereunder, unless such Holder shall have previously given the Trustee written notice of a continuing Event of Default with respect to
the Securities of this series, the Holders of not less than 25% in principal amount of the Securities of all such affected series at the time outstanding shall have made written request to the Trustee to institute proceedings in respect of such
Event of Default in its own name as Trustee and offered the Trustee indemnity reasonably satisfactory to the Trustee against any costs, liabilities or expenses to be incurred in compliance with such request and, for 60 days after receipt of
such notice, request and offer of indemnity, the Trustee shall have failed to institute any such proceeding, and, during such 60-day period, the Trustee shall not have received from the Holders of a majority in principal amount of the Securities of
this series at the time outstanding a direction inconsistent with such request. The foregoing shall not apply to any suit instituted by the Holder of this Security for the enforcement of any payment of Principal hereof or any premium or interest
hereon on or after the respective due dates expressed herein. 
 The Indenture permits, with certain exceptions as therein provided, the
amendment thereof and the modification of the rights and obligations of the Company and the rights of the Holders of the Securities under the Indenture at any time by the Company and the Trustee with the consent of the Holders of not less than a
majority in principal amount of the outstanding Securities affected by such amendment. The Indenture also contains provisions permitting the Holders of specified percentages in principal amount of the Securities at the time outstanding, on behalf of
the Holders of all Securities, to waive compliance by the Company with certain 

  
 3 

 
provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any such consent or waiver by the Holder of this Security shall be conclusive and binding upon
such Holder and upon all future Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation of such consent or waiver is made upon this Security. 

No reference herein to the Indenture and no provision of this Security or of the Indenture shall alter or impair the obligation of the
Company, which is absolute and unconditional, to pay the Principal of (and premium, if any) and interest on this Security at the times, place and rate, and in the coin or currency, herein prescribed. 

As provided in the Indenture and subject to certain limitations therein set forth, the transfer of this Security is registrable in the
Security Register, upon surrender of this Security for registration of transfer at the office or agency of the Company in any place of payment where the Principal of and interest on this Security are payable, duly endorsed by, or accompanied by a
written instrument of transfer in form satisfactory to the Company and the Trustee for the Securities duly executed by the Holder hereof or his attorney duly authorized in writing, and thereupon one or more new Securities of this series, of
authorized denomination and for the same aggregate principal amount, will be issued to the designated transferee or transferees. 
 The
Securities of this series are issuable only in registered form without coupons in denominations of $1,000 and any integral multiple thereof. As provided in the Indenture and subject to certain limitations set forth therein, Securities of this series
are exchangeable for a like aggregate principal amount of Securities of this series of a different authorized denomination, as requested by the Holder surrendering the same. 

No service charge shall be made for any such registration of transfer or exchange, but the Company may require payment of a sum sufficient to
cover any tax or other governmental charge payable in connection therewith. 
 Prior to due presentment of this Security for registration of
transfer, the Company, the Trustee and any agent of the Company or the Trustee may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and none of the Company, the
Trustee or any such agent shall be affected by notice to the contrary. 
 The obligations of the Company under the Indenture and this
Security and all documents delivered in the name of the Company in connection herewith and therewith do not and shall not constitute personal obligations of the directors, officers, employees, agents or shareholders of the Company or any of them,
and shall not involve any claim against or personal liability on the part of any of them, and all persons including the Trustee shall look solely to the assets of the Company for the payment of any claim thereunder or for the performance thereof and
shall not seek recourse against such directors, officers, employees, agents or shareholders of the Company or any of them or any of their personal assets for such satisfaction. The performance of the obligations of the Company under the Indenture
and this Security and all documents delivered in the name of the Company in connection therewith shall not be deemed a waiver of any rights or powers of the Company or its directors or shareholders under the Company’s Memorandum and Articles of
Association. 
 All terms used in this Security that are defined in the Indenture shall have the meanings assigned to them in the Indenture.

 The Indenture and the Securities, including this Security, shall be governed by and construed in accordance with the law of the State
of New York. 
 Pursuant to a recommendation promulgated by the Committee on Uniform Security Identification Procedures, the Company has
caused “CUSIP” numbers to be printed on the Securities as a convenience to the Holders of the Securities. No representation is made as to the correctness or accuracy of such CUSIP numbers as printed on the Securities, and reliance may be
placed only on the other identification numbers printed hereon. 

  
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 ASSIGNMENT FORM 

FOR VALUE RECEIVED, the undersigned hereby 

sells, assigns and transfers unto 
 PLEASE INSERT
SOCIAL 
 SECURITY OR OTHER IDENTIFYING 
 NUMBER OF ASSIGNEE

  

							
	 	 		 	 	 	 
	 	 		 		 	

	
	  

	(Please Print or Typewrite Name and Address, including Zip Code, of Assignee)
	  

	the within Security of GlaxoSmithKline plc and                      hereby does irrevocably constitute and appoint
	
	  

	attorney to transfer said Security on the books kept for the registration thereof with full power of substitution in the premises

 

			
	Dated:	 	  

 

			
	Signature:	 	  

	NOTICE: The signature to this assignment must correspond with the name as it appears on the first page of the within Security in every particular, without alteration or enlargement or any change
whatever.

  

			
	Signature Guaranteed:	 	  

	NOTICE: Signature(s) must be guaranteed by an “eligible guarantor institution” that is a member or participant in a “signature guarantee program” (e.g., the
Securities Transfer Agents Medallion Program, the Stock Exchange Medallion Program and the New York Stock Exchange Medallion Program).

  
 5

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