Document:

Exhibit 10.5 

 

SECURITIES
PURCHASE AGREEMENT

 

THIS SECURITIES PURCHASE AGREEMENT
(this “Agreement”) is made effective as of 12:01 a.m. on September 29, 2021 (the “SPA
Effective Date”), by and among Amicus Therapeutics, Inc., a Delaware corporation with its principal place of business
at 3675 Market Street, Philadelphia, PA 19104 (“Amicus”), and each Purchaser identified on the signature pages hereto
(each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”).

 

BACKGROUND

 

Amicus desires to sell to
each Purchaser and each Purchaser desires to purchase from Amicus such number of Shares (as defined below) set forth opposite such Purchaser’s
name on Schedule A attached hereto, at a price of $10.18 per Share (the “Per Share Price”) and on the
terms and subject to the conditions set forth in this Agreement (the “Offering”).

 

TERMS

 

NOW, THEREFORE, in consideration
of the foregoing recitals and the mutual covenants and agreements contained herein, the Parties hereto, intending to be legally bound,
do hereby agree as follows:

 

1.             Definitions.
The capitalized terms used herein shall have the meanings ascribed to them below or at such other place in this Agreement as is indicated
below:

 

1.1           “Affiliate”
means, with respect to any specified Person, at any time, a Person that, directly or indirectly, through one or more intermediaries, controls,
or is controlled by, or is under common control with, such specified Person at such time. For purposes of this definition, “control,”
when used with respect to any specified Person, shall mean (a) the direct or indirect ownership of more than 50% (or such lesser
percentage which is the maximum allowed to be owned by a foreign corporation in a particular jurisdiction) of the total voting power of
securities or other evidences of ownership interest in such Person or (b) the power to direct or cause the direction of the management
and policies of such Person, directly or indirectly, whether through ownership of voting securities, by contract or otherwise.

 

1.2           “Closing”
has the meaning ascribed to such term in Section 3.1.

 

1.3           “Common
Stock” means the common stock of Amicus, par value $0.01 per share, and any other class of securities into which such securities
may hereafter be reclassified or changed into.

 

1.4           “Cut
Back Shares” has the meaning ascribed to such term in Section 6.1.

 

1.5           “Exchange
Act” means the Securities Exchange Act of 1934, as amended, together with the rules and regulations promulgated thereunder.

 

1.6           “FDA”
has the meaning ascribed to such term in Section 4.7

 

    

     

    

 

1.7           “FDA
Documents” has the meaning ascribed to such term in Section 4.7.

 

1.8           “GAAP”
means generally accepted accounting principles in the United States.

 

1.9           “Holder”
means each Person owning of record Registrable Securities that have not been sold to the public.

 

1.10         “Indemnified
Party” has the meaning ascribed to such term in Section 6.5(c).

 

1.11         “Indemnifying
Party” has the meaning ascribed to such term in Section 6.5(c).

 

1.12         “Knowledge”
means the knowledge of such Person, assuming that such Person engaged in reasonable inquiry or investigation with respect to the relative
subject matter.

 

1.13         “Lock-Up
Period” has the meaning ascribed to such term in Section 7.1.

 

1.14         “Material
Adverse Effect” on or with respect to an entity (or group of entities taken as a whole) means any state of facts, event,
change or effect that has had, or that would reasonably expected to have, (i) a material adverse effect on the business, properties,
prospects, results of operations or financial condition of such entity (or of such group of entities taken as a whole) or (ii) a
material adverse effect on the performance of this Agreement or the consummation of any of the transactions contemplated hereby.

 

1.15         “Nasdaq”
means the Nasdaq Stock Market, Inc.

 

1.16         “Offering”
has the meaning ascribed to such term in the Background.

 

1.17         “Party”
means a party to this Agreement.

 

1.18         “Per
Share Price” has the meaning ascribed to such term in the Background.

 

1.19         “Person”
means any individual, firm, corporation, partnership, limited liability company, trust, incorporated or unincorporated association, joint
venture, joint stock company, government (or an agency or political subdivision thereof) or other entity of any kind, and shall include
any successor (by merger or otherwise) of such entity.

 

1.20         “Press
Release” has the meaning ascribed to such term in Section 9.3.

 

1.21         “Purchase
Price” has the meaning ascribed to such term in Section 2.1.

 

1.22         “Purchaser
Indemnitee” has the meaning ascribed to such term in Section 6.5.

 

1.23         “Register,”
 “Registered,” and “Registration” refer to a registration effected by preparing and
filing a Registration Statement in compliance with the Securities Act, and the declaration or ordering of effectiveness of such Registration
Statement or document by the SEC.

 

1.24         “Registrable
Securities” means (a) the Shares and (b) any shares of Common Stock or other securities issued as (or issuable
upon the conversion or exercise of any warrant, right or other security which is issued as) a dividend or other distribution with respect
to, or in exchange for or in replacement of, the Shares by way of stock dividend, stock split or in connection with a combination of shares,
recapitalization or other reorganization or otherwise. Notwithstanding the foregoing, as to any particular Shares or other securities
described above, once issued they shall cease to be Registrable Securities when (i) a registration statement with respect to the
sale of such securities shall have become effective under the Securities Act and such securities shall have been disposed of in accordance
with such registration statement, (ii) they shall have been distributed pursuant to Rule 144 (or any successor provision) under
the Securities Act, (iii) such securities may be sold without volume restrictions pursuant to Rule 144, as determined by the
counsel to Amicus pursuant to a written opinion letter to such effect, addressed and acceptable to Amicus’ transfer agent, or (iv) such
securities shall have been otherwise transferred in a private transaction in which the rights under Section 6 hereof have
not been assigned in connection with such transfer.

 

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1.25         “Registration
Period” has the meaning ascribed to such term in Section 6.3(a).

 

1.26         “Registration
Statement” means a registration statement filed pursuant to the Securities Act.

 

1.27         “Restriction
Termination Date” has the meaning ascribed to such term in Section 6.1.

 

1.28         “Rule 144”
means Rule 144 promulgated under the Securities Act, or any successor rule.

 

1.29         “Sanctions”
has the meaning ascribed to such term in Section 4.20.

 

1.30         “Sanctioned
Country” has the meaning ascribed to such term in Section 4.20.

 

1.31         “SEC”
means the U.S. Securities and Exchange Commission.

 

1.32         “SEC
Documents” has the meaning ascribed to such term in Section 4.7.

 

1.33         “SEC
Guidance” means (a) any publicly-available written guidance, or rule of general applicability of the SEC staff,
or (b) written comments, requirements or requests of the SEC staff to Amicus in connection with the review of a Registration Statement.

 

1.34         “SEC
Restrictions” has the meaning ascribed to such term in Section 6.1.

 

1.35         “Securities
Act” means the Securities Act of 1933, as amended, together with the rules and regulations promulgated thereunder.

 

1.36         “Purchase
Price” has the meaning ascribed to such term in Section 2.1.

 

1.37         “Shares”
means the shares of Common Stock to be issued to each Purchaser pursuant to this Agreement.

 

1.38         “Trading
Day” means a day on which the Common Stock is traded on Nasdaq.

 

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1.39         “Transaction
Documents” means this Agreement and any other documents or agreements executed in connection with the transactions contemplated
hereunder.

 

1.40         “Transfer
Agent” means American Stock Transfer & Trust Company, LLC, the company’s transfer agent and registrar for
Common Stock, and any successor appointed in such capacity.

 

2.             Purchase
and Sale.

 

2.1           On
terms and conditions as set forth herein, Amicus hereby issues and sells to the Purchasers, and the Purchasers hereby purchase from Amicus,
an aggregate of 7,858,546 Shares at the Per Share Price for an aggregate purchase price of $79,999,998.66 (the “Purchase Price”).

 

2.2           Schedule
A hereto sets forth the number of Shares to be purchased by each Purchaser and the portion of the Purchase Price to be paid by such
Purchaser for such Shares.

 

3.             Closing.

 

3.1           Closing.
The completion of the sale and purchase of the Shares (the “Closing”) shall occur upon the execution of this
Agreement.

 

3.2           Deliveries.
Subject to the terms and conditions hereof:

 

(a)            Each
Purchaser shall deliver to Amicus the Purchase Price attributable to the Shares purchased by such Purchaser by wire transfer of immediately
available funds to the following account:

 

	Bank:
	Bank Address:
	Beneficiary:
	Beneficiary Address:
	ABA:
	Account:
	SWIFT Code:

 

(b)            Upon
receipt of a Purchaser’s share of the Purchase Price, Amicus shall deliver to such Purchaser the applicable Shares to be registered
in book entry form in the name of such Purchaser on Amicus’s share register. Within one (1) business day of the date hereof,
Amicus will provide each Purchaser with written confirmation of the registration contemplated by Section 3(b)(i). Each of
the Parties shall also deliver such other documents as are required to be delivered by the Parties pursuant to the terms of this Agreement.

 

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4.             Representations
and Warranties of Amicus. Except as disclosed in Amicus’ disclosure schedules provided to the Purchasers along with this
Agreement, Amicus hereby represents and warrants to the Purchasers as of the SPA Effective Date (except as set forth below), as follows:

 

4.1           Capitalization.
As of September 27, 2021, the authorized capital stock of Amicus consisted of (a) 500,000,000 shares of Common Stock, of which
(i) 267,287,163 shares were issued and outstanding, and (ii) 40,298,907 shares have been reserved for issuance under Amicus’
Amended and Restated 2007 Equity Incentive Plan; and (b) 10,000,000 shares of preferred stock, none of which is issued and outstanding.
All issued and outstanding shares of Amicus’ capital stock have been duly authorized and validly issued, and are fully paid and
nonassessable, and were issued in compliance with all applicable federal and state securities laws. As of the SPA Effective Date, there
are no preemptive or similar rights on the part of any holder of any class or securities of Amicus. As of the SPA Effective Date, except
as set forth in the SEC Documents or as described or referred to above, there are no securities convertible into or exchangeable for,
or options, warrants, calls, subscriptions, rights, contracts, commitments, or understandings of any kind to which Amicus is a party or
by which it is bound obligating Amicus to issue, deliver or sell, or cause to be issued, delivered or sold additional shares of its capital
stock or other voting securities of Amicus. As of the SPA Effective Date, there are no outstanding agreements of Amicus to repurchase,
redeem or otherwise acquire any shares of its capital stock.

 

4.2           Litigation.
There are no actions, suits, proceedings or, to its Knowledge, any investigations, pending or currently threatened against Amicus that
questions the validity of this Agreement or the issuance of the Common Stock contemplated hereby, nor to its Knowledge, is there any basis
therefor. As of the SPA Effective Date, there is no other material action, suit, or proceeding pending or, to the Knowledge of Amicus,
currently threatened against Amicus. As of the SPA Effective Date, there are no material outstanding consents, orders, decrees or judgments
of any governmental entity naming Amicus.

 

4.3           Organization
and Good Standing. Amicus is a corporation duly organized, validly existing and in good standing under the laws of the State of Delaware
and has all requisite corporate power and authority to own, lease and operate its properties and carry on its business as now conducted.
Amicus is duly qualified and is in good standing as a foreign corporation in each jurisdiction in which the properties owned, leased or
operated, or the business conducted, by it requires such qualification except where the failure to be so qualified or in good standing,
individually or in the aggregate, would not have a Material Adverse Effect.

 

4.4           Authorization.
All corporate actions on the part of Amicus, its officers, directors and stockholders necessary for the authorization, execution and delivery
of each of the Transaction Documents and for the issuance of the Shares have been taken. Amicus has the requisite corporate power to enter
into each of the Transaction Documents and to carry out and perform its obligations thereunder. Each of the Transaction Documents have
been duly authorized, executed and delivered by Amicus and, upon due execution and delivery by the Purchasers, each of the Transaction
Documents will be a valid and binding agreement of Amicus, except as enforceability may be limited by bankruptcy, insolvency, reorganization,
moratorium or similar laws affecting creditors’ rights generally or by equitable principles.

 

4.5           Subsidiaries.
Except as set forth in the disclosure schedules to this Agreement, Amicus does not currently own or control, directly or indirectly, any
interest in any other corporation, partnership, trust, joint venture, limited liability company, association, or other business entity.
Amicus is not a participant in any joint venture, partnership or similar arrangement other than as has been disclosed in SEC Documents.

 

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4.6           No
Conflict With Other Instruments. Neither the execution, delivery nor performance of any of the Transaction Documents, nor the consummation
by Amicus of the transactions contemplated hereby will result in any violation of, be in conflict with, cause any acceleration or any
increased payments under, or constitute a default under, with or without the passage of time or the giving of notice: (a) any provision
of Amicus’ certificate of incorporation or bylaws as in effect at the Closing; (b) any provision of any law, regulation, judgment,
decree or order to which Amicus is a party or by which it or any of its assets is bound, (c) any note, mortgage, contract, agreement,
license, waiver, exemption, order or permit.

 

4.7           Disclosure
Documents.

 

(a)            For
the two years preceding the SPA Effective Date, Amicus has filed, on a timely basis or has received a valid extension as of such time
of filing and has thereafter made such filings prior to the expiration of any such extensions, all reports, schedules, forms, statements
and other documents required to be filed by Amicus with the SEC under the Securities Act and the Exchange Act, including pursuant to Section 13(a) or
15(d) thereof, (the foregoing materials, including the exhibits thereto and documents incorporated by reference therein, being collectively
referred to herein as the “SEC Documents”) and with the U.S. Food and Drug Administration (“FDA”)
under its applicable regulations (“FDA Documents”), and Amicus has paid all fees and assessments due and payable
in connection with the SEC Documents and the FDA Documents. As of their respective dates, the SEC Documents and the FDA Documents complied
in all material respects with all statutes and applicable rules and regulations of the SEC or FDA, as applicable, including the requirements
of the Securities Act or the Exchange Act, as applicable, and none of the SEC Documents or FDA Documents, when filed, contained any untrue
statement of a material fact or omitted to state a material fact required to be stated therein or necessary in order to make the statements
therein, in the light of the circumstances under which they were made, not misleading.

 

(b)            The
audited financial statements of Amicus included in Amicus’ SEC Documents comply in all material respects with the published rules and
regulations of the SEC with respect thereto, and such audited financial statements (i) were prepared from the books and records of
Amicus, (ii) were prepared in accordance with GAAP applied on a consistent basis (except as may be indicated therein or in the notes
or schedules thereto) and (iii) present fairly the financial position of Amicus as of the dates thereof and the results of operations
and cash flows for the periods then ended. The unaudited financial statements included in the SEC Documents comply in all material respects
with the published rules and regulations of the SEC with respect thereto, and such unaudited financial statements (i) were prepared
from the books and records of Amicus, (ii) were prepared in accordance with GAAP, except as otherwise permitted under the Exchange
Act and the rules and regulations thereunder, applied on a consistent basis (except as may be indicated therein or in the notes or
schedules thereto) and (iii) present fairly the financial position of Amicus as of the dates thereof and the results of operations
and cash flows (or changes in financial condition) for the periods then ended, subject to normal year-end adjustments and any other adjustments
described therein or in the notes or schedules thereto. The interactive data in eXtensible Business Reporting Language included in the
SEC Documents fairly presents the information called for in all material respects and has been prepared in all material respects in accordance
with the SEC’s rules and guidelines applicable thereto.

 

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4.8           Absence
of Certain Events and Changes. Since the date of Amicus’ Quarterly Report on Form 10-Q for the quarter ended on June 30,
2021: (a) Amicus has conducted its business in the ordinary course consistent with past practice, (b) there has not been any
event, change or development which, individually or in the aggregate, would have a Material Adverse Effect, taken as a whole, (c) Amicus
has not incurred any material liabilities (contingent or otherwise) other than expenses incurred in the ordinary course of business consistent
with past practice, (d) Amicus has not altered its method of accounting in any material respect, and (e) Amicus has not declared
or made any dividend or distribution of cash or other property to its stockholders or purchased, redeemed or made any agreements to purchase
or redeem any shares of its capital stock.

 

4.9           Intellectual
Property. Amicus owns, or has an exclusive right pursuant to a valid, written license agreement to use and exploit, all material intellectual
property used in or necessary for the conduct of the business of Amicus as conducted as of the Closing and the conduct of its business
will not conflict in any material respect with any such rights of others. No claims have been asserted by a third party in writing (a) alleging
that the conduct of the business of Amicus has infringed or misappropriated any intellectual property rights of such third party, or (b) challenging
or questioning the validity or effectiveness of any intellectual property right of Amicus, and, to the Knowledge of Amicus, there is no
valid basis for any such claim (a) or (b). To the Knowledge of Amicus, no third party is misappropriating or infringing any intellectual
property right of Amicus. No loss or expiration of any of Amicus’ material intellectual property is pending, or, to the Knowledge
of Amicus, threatened. Amicus has taken reasonable steps in accordance with standard industry practices to protect its rights in its Intellectual
Property and at all times has maintained the confidentiality of all information used in connection with the business that constitutes
or constituted a trade secret of Amicus.

 

4.10         Compliance
with Applicable Law. Amicus has all material permits, licenses, franchises, authorizations, orders and approvals of, and has made
all filings, applications and registrations with, governmental entities that are required in order to permit Amicus to own or lease properties
and assets and to carry on its business as presently conducted that are material to Amicus. Amicus has complied and is in compliance in
all material respects with all statutes, laws, regulations, rules, judgments, orders and decrees of all governmental entities applicable
to it that relate to its business. Except as set forth in the disclosure schedules to this Agreement, Amicus has not received any notice
alleging noncompliance, and, to the Knowledge of Amicus, Amicus is not under investigation with respect to, or threatened to be charged,
with any material violation of any applicable statutes, laws, regulations, rules, judgments, orders or decrees of any governmental entities.

 

4.11         Valid
Issuance of Shares. When issued, sold and delivered in accordance with the terms hereof for the consideration expressed herein, the
Shares will be duly and validly authorized and issued, fully paid and non-assessable, free and clear of all liens, and, based in part
on the representations of the Purchasers in Section 5 of this Agreement, will be issued in compliance with all applicable
federal and state securities laws.

 

4.12         Governmental
Consents. No consent, approval, order or authorization of, or registration, qualification, designation, declaration or filing with,
any federal, state or local governmental authority on the part of Amicus is required in connection with the consummation of the transactions
contemplated by the Transaction Documents, except for notices required or permitted to be filed with certain state and federal securities
commissions, which notices will be filed on a timely basis.

 

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4.13         No
Brokers. No broker, finder or investment banker is entitled to any brokerage, finder’s or other fee or commission in connection
with the transactions contemplated by the Transaction Documents based on arrangements made by Amicus.

 

4.14         No
Undisclosed Liabilities. Amicus does not have any liabilities (contingent or otherwise), except for (a) liabilities reflected
or reserved against in financial statements of Amicus included in the SEC Documents filed with the SEC prior to the date of each of the
Transaction Documents, and (b) liabilities that have not been and would not reasonably be expected to be material.

 

4.15         Internal
Controls. Amicus maintains a system of internal accounting controls sufficient to provide reasonable assurance that (i) transactions
are executed in accordance with management’s general or specific authorizations, (ii) transactions are recorded as necessary
to permit preparation of financial statements in conformity with GAAP and to maintain asset and liability accountability, and (iii) access
to assets or incurrence of liabilities is permitted only in accordance with management’s general or specific authorization. Since
the end of Amicus’s most recent audited fiscal year, to its Knowledge, there have been no significant deficiencies or material weakness
detected in Amicus’s internal control over financial reporting (whether or not remediated) and no change in Amicus’s internal
control over financial reporting that has materially affected, or is reasonably likely to materially affect, Amicus’s internal control
over financial reporting. Amicus is not aware of any change in its internal controls over financial reporting that has occurred during
its most recent fiscal quarter that has materially affected, or is reasonably likely to materially affect, Amicus’s internal control
over financial reporting.

 

4.16         Disclosure
Controls. Amicus and its subsidiaries maintain an effective system of “disclosure controls and procedures” (as defined
in Rule 13a-15(e) of the Exchange Act) that complies in all material respects with the requirements of the Exchange Act and
that has been designed to ensure that information required to be disclosed by Amicus in reports that it files or submits under the Exchange
Act is recorded, processed, summarized and reported within the time periods specified in the SEC’s rules and forms, including
controls and procedures designed to ensure that such information is accumulated and communicated to Amicus’s management as appropriate
to allow timely decisions regarding required disclosure.

 

4.17         Compliance.
Amicus is not (i) in default under or in violation of (and no event has occurred that has not been waived that, with notice or lapse
of time or both, would result in a default by Amicus under), nor has Amicus received notice of a claim that it is in default under or
that it is in violation of, any indenture, loan or credit agreement or any other agreement or instrument to which it is a party or by
which it or any of its properties is bound (whether or not such default or violation has been waived), (ii) in violation of any judgment,
decree or order of any court, arbitrator or governmental body or (iii) in violation of any statute, rule, ordinance or regulation
of any governmental authority, including without limitation all foreign, federal, state and local laws relating to environmental protection,
occupational health and safety, product quality and safety and employment and labor matters, except in each case as would not have or
reasonably be expected to result in a Material Adverse Effect.

 

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4.18         No
Unlawful Payments. Neither Amicus nor any of its subsidiaries nor, to the knowledge of Amicus, any director, officer, employee, agent,
affiliate or other person associated with or acting on behalf of the Company or any of its subsidiaries has (i) used any corporate
funds for any unlawful contribution, gift, entertainment or other unlawful expense relating to political activity; (ii) made or taken
an act in furtherance of an offer, promise or authorization of any direct or indirect unlawful payment or benefit to any foreign or domestic
government official or employee, including of any government-owned or controlled entity or of a public international organization, or
any person acting in an official capacity for or on behalf of any of the foregoing, or any political party or party official or candidate
for political office; (iii) violated or is in violation of any provision of the Foreign Corrupt Practices Act of 1977, as amended,
or any applicable law or regulation implementing the OECD Convention on Combating Bribery of Foreign Public Officials in International
Business Transactions, or committed an offence under the Bribery Act 2010 of the United Kingdom or any other applicable anti-bribery or
anti-corruption law; or (iv) made, offered, agreed, requested or taken an act in furtherance of any unlawful bribe or other unlawful
benefit, including, without limitation, any rebate, payoff, influence payment, kickback or other unlawful or improper payment or benefit.
Amicus and its subsidiaries have instituted, maintain and enforce, and will continue to maintain and enforce policies and procedures designed
to promote and ensure compliance with all applicable anti-bribery and anti-corruption laws.

 

4.19         Compliance
with Anti-Money Laundering Laws. The operations of Amicus and its subsidiaries are and have been conducted at all times in compliance
with applicable financial recordkeeping and reporting requirements, including those of the Currency and Foreign Transactions Reporting
Act of 1970, as amended, the applicable money laundering statutes of all jurisdictions where the Company or any of its subsidiaries conducts
business, the rules and regulations thereunder and any related or similar rules, regulations or guidelines issued, administered or
enforced by any governmental agency (collectively, the “Anti-Money Laundering Laws”) and no action, suit or
proceeding by or before any court or governmental agency, authority or body or any arbitrator involving the Company or any of its subsidiaries
with respect to the Anti-Money Laundering Laws is pending or, to the knowledge of the Company, threatened.

 

4.20         No
Conflicts with Sanctions Laws. Neither Amicus nor any of its subsidiaries nor, to the knowledge of Amicus, any director, officer,
employee, agent, affiliate or other person associated with or acting on behalf of Amicus or any of its subsidiaries is currently the subject
or the target of any sanctions administered or enforced by the U.S. government, (including, without limitation, the Office of Foreign
Assets Control of the U.S. Department of the Treasury or the U.S. Department of State and including, without limitation, the designation
as a “specially designated national” or “blocked person”), the United Nations Security Council the European Union,
Her Majesty’s Treasury or other relevant sanctions authority (collectively, “Sanctions”), nor is the Company,
any of its subsidiaries located, organized or resident in a country or territory that is the subject or target of Sanctions, including,
without limitation, Crimea, Cuba, Iran, North Korea and Syria (each, a “Sanctioned Country”); and Amicus
will not directly or indirectly use the proceeds of the offering of the Shares hereunder, or lend, contribute or otherwise make available
such proceeds to any subsidiary, joint venture partner or other person or entity (i) to fund or facilitate any activities of or business
with any person that, at the time of such funding or facilitation, is the subject or target of Sanctions, (ii) to fund or facilitate
any activities of or business in any Sanctioned Country or (iii) in any other manner that will result in a violation by any person
(including any person participating in the transaction, whether as underwriter, advisor, investor or otherwise) of Sanctions. For the
past five years, Amicus and its subsidiaries have not knowingly engaged in and are not now knowingly engaged in any dealings or transactions
with any person that at the time of the dealing or transaction is or was the subject or the target of Sanctions or with any Sanctioned
Country.

 

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4.21         Investment
Company. Amicus is not required to be registered as, and immediately following the Closing will not be required to register as, an
 “investment company” within the meaning of the Investment Company Act of 1940, as amended.

 

4.22         Bad
Actor Disqualification. None of Amicus, any predecessor or affiliated issuer of Amicus nor, to Amicus’s Knowledge, any director
or executive officer of Amicus or any promoter connected with Amicus in any capacity, is subject to any of the “bad actor”
disqualifications within the meaning of Rule 506(d) under the Securities Act, except for a disqualification event covered by
Rule 506(d)(2) or (d)(3).

 

4.23         Investment
Matters. Assuming the accuracy of each Purchaser’s representations and warranties set forth in Section 5, no registration
under the Securities Act is required for the offer and sale of the Shares to the Purchasers hereunder. The Shares (i) were not offered
to the Purchasers by any form of general solicitation or general advertising and (ii) are not being offered to the Purchasers in
a manner involving a public offering under, or in a distribution in violation of, the Securities Act, or any state securities laws.

 

5.             Representations
And Warranties Of Purchasers. Each Purchaser hereby represents and warrants to Amicus as of the SPA Effective Date as follows:

 

5.1           Legal
Power. Purchaser has the requisite corporate power to enter into each of the Transaction Documents, and to carry out and perform its
obligations under the terms of the Transaction Documents.

 

5.2           Due
Execution. Each of the Transaction Documents have been duly authorized, executed and delivered by Purchaser, and, upon due execution
and delivery by Amicus, each of the Transaction Documents will be a valid and binding agreement of Purchaser, except as enforceability
may be limited by bankruptcy, insolvency, reorganization, moratorium or similar laws affecting creditors’ rights generally or by
equitable principles.

 

5.3           Investment
Representations. In connection with the offer, purchase and sale of the Shares Purchaser makes the following representations:

 

(a)            Purchaser
is acquiring the Shares for its own account, not as nominee or agent, for investment and not with a view to, or for resale in connection
with, any distribution or public offering thereof within the meaning of the Securities Act.

 

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(b)            Purchaser
understands that:

 

(i)            The
Shares have not been registered under the Securities Act by reason of a specific exemption therefrom, that such securities may be required
to be held by it indefinitely under applicable securities laws, and that each Purchaser must, therefore, bear the economic risk of such
investment indefinitely, unless a subsequent disposition thereof is registered under the Securities Act or is exempt from such registration.

 

(ii)           Each
book entry position representing Shares will be endorsed with the following legend:

 

THE SECURITIES REPRESENTED HEREBY HAVE
NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR UNDER THE SECURITIES LAWS OF CERTAIN STATES.
THESE SECURITIES ARE SUBJECT TO RESTRICTIONS ON TRANSFERABILITY AND RESALE AND MAY NOT BE TRANSFERRED OR RESOLD EXCEPT AS PERMITTED
UNDER THE ACT AND ANY APPLICABLE STATE SECURITIES LAWS, PURSUANT TO REGISTRATION OR EXEMPTION THEREFROM OR UNLESS THE COMPANY HAS RECEIVED
AN OPINION OF COUNSEL SATISFACTORY TO THE COMPANY AND ITS COUNSEL THAT SUCH REGISTRATION IS NOT REQUIRED.

 

; and

 

(iii)          Amicus
will instruct its transfer agent not to register the transfer of the Shares or any portion thereof, unless the conditions specified in
the foregoing legend are satisfied.

 

(c)            Each
Purchaser has such knowledge and experience in financial or business matters that it is capable of evaluating the merits and risks of
the investment in the Shares to be purchased hereunder.

 

(d)            Each
Purchaser acknowledges and agrees that the Purchaser is purchasing the Shares from Amicus. Each Purchaser further acknowledges that there
have been no representations, warranties, covenants and agreements made to the Purchaser by or on behalf of Amicus or any of its respective
affiliates or any control persons, officers, directors, employees, partners, agents or representatives of any of the foregoing or any
other person or entity, expressly or by implication, other than those representations, warranties, covenants and agreements of Amicus
expressly set forth in this Agreement.

 

(e)            Each
Purchaser is an “accredited investor” as such term is defined in Rule 501(a) of the rules and regulations promulgated
under the Securities Act. Each Purchaser acknowledges that it is aware that there are substantial risks incident to the purchase and ownership
of the Shares, including, without limitation, those set forth in the SEC Documents.

 

(f)             Each
Purchaser became aware of this offering of the Shares solely by means of direct contact between the Purchaser and Amicus or a representative
of Amicus, and the Shares were offered to the Purchaser solely by direct contact between the Purchaser and the Amicus or a representative
of Amicus. The Purchaser did not become aware of this offering of the Shares, nor were the Shares offered to the Purchaser, by any other
means.

 

    -11-

     

    

 

6.             Registration
Rights.

 

6.1           Registration.
As soon as reasonably practicable, but no event later than 50 days after the Closing, Amicus shall prepare and file with the SEC a Registration
Statement covering the resale of all, or such portion as permitted by SEC Guidance (provided that, Amicus shall use commercially reasonable
efforts to advocate with the SEC for the registration of the maximum number of the Registrable Securities permitted by SEC Guidance),
of the Registrable Securities and use commercially reasonable efforts to cause a Registration Statement to be declared effective (including,
without limitation, the execution of any required undertaking to file post-effective amendments) as promptly as possible after the filing
thereof, but in no event later than ten (10) business days after the SEC has notified that Amicus that it will not review, or has
completed its review, of the Registration Statement. The Registration Statement shall be on Form S-3 (except if Amicus fails to meet
one or more of the registrant requirements specified in General Instruction I.A. on Form S-3, such registration shall be on another
appropriate form in accordance herewith). In the event that, despite Amicus’s commercially reasonable efforts and compliance with
the terms of this Section 6.1, the SEC refuses to alter its position, the Company shall (i) remove from the Registration
Statement such portion of the Registrable Securities (the “Cut Back Shares”) and/or (ii) agree to such
restrictions and limitations on the registration and resale of the Registrable Securities as the staff of the SEC may require to assure
Amicus’s compliance with the requirements of Rule 415 (collectively, the “SEC Restrictions”); provided,
however, that Amicus shall not agree to name any Purchaser as an “underwriter” in such Registration Statement without the
prior written consent of such Purchaser. Any cutback imposed on the Purchasers pursuant to this Section 6.1 shall be allocated
among the Purchasers on a pro rata basis, unless the SEC Restrictions otherwise require or provide or the Purchasers holding a majority
of the Registrable Shares otherwise agree. From and after the such date as the Company is able to effect the registration of such Cut
Back Shares in accordance with any SEC Restrictions (such date, the “Restriction Termination Date” of such Cut
Back Shares) applicable to any Cut Back Shares, all of the provisions of this Section 6 shall again be applicable to such
Cut Back Shares; provided, however, that (x) the Filing Deadline for the Registration Statement including such Cut Back Shares shall
be 10 business days after such Restriction Termination Date.

 

6.2           Expenses
Of Registration. Amicus shall pay all fees and expenses incurred in connection with any registration, qualification, exemption or
compliance by Amicus in the performance of its obligations pursuant to this Section 6, whether or not any Registrable Securities
are sold pursuant to a Registration Statement, and including all registration and filing fees, exchange listing fees, and the fees and
expenses of counsel and accountants for Amicus.

 

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6.3           Obligations
Of Amicus. In the case of registration, qualification, exemption or compliance effected by Amicus pursuant to the Transaction Documents,
Amicus will, upon request of any Purchaser, inform such Purchaser as to the status of such registration, qualification, exemption and
compliance. Amicus shall, at its expense and in addition to its obligations under Section 6.1, as expeditiously as reasonably
possible:

 

(a)            use
its commercially reasonable efforts to keep such registration, and any required qualification, exemption or compliance under state securities
laws, continuously effective with respect to the Purchasers and its permitted assignees, until the date all Shares registered by such
Registration Statement shall have been sold or may be sold pursuant to Rule 144 without regard to volume limitations. The period
of time during which Amicus is required hereunder to keep the Registration Statement effective is referred to herein as the “Registration
Period.”

 

(b)           advise
Purchasers promptly (and, in any event, within five business days):

 

(i)            when
the Registration Statement or any amendment thereto has been filed with the SEC and when the Registration Statement or any post-effective
amendment thereto has become effective;

 

(ii)           of
the receipt by Amicus of any notification from the SEC of any stop order suspending the effectiveness of the Registration Statement or
the initiation of any proceedings for such purpose;

 

(iii)          of
the receipt by Amicus of any notification with respect to the suspension of the qualification of the Registrable Securities included therein
for sale in any jurisdiction or the initiation or threatening of any proceeding for such purpose; and

 

(iv)          of
the occurrence of any event that requires the making of any changes in the Registration Statement or the prospectus so that, as of such
date, the statements therein are not misleading and do not omit to state a material fact required to be stated therein or necessary to
make the statements therein (in the case of the prospectus, in the light of the circumstances under which they were made) not misleading;

 

(c)            use
its commercially reasonable efforts to obtain the withdrawal of any order suspending the effectiveness of any Registration Statement as
soon as reasonably practicable;

 

(d)           if
any Purchaser so requests in writing, promptly furnish to such Purchaser, without charge, at least one copy of such Registration Statement
and any post-effective amendment thereto, including financial statements and schedules, and, if explicitly requested, all exhibits in
the form filed with the SEC;

 

(e)            during
the Registration Period, promptly deliver to each Purchaser, without charge, at least one copy of the prospectus included in such Registration
Statement and any amendment or supplement thereto and as many additional copies as each Purchaser may reasonably request; and Amicus consents
to the use, consistent with the provisions hereof, of the prospectus or any amendment or supplement thereto by each Purchaser in connection
with the offering and sale of the Registrable Securities covered by the prospectus or any amendment or supplement thereto;

 

(f)             during
the Registration Period, if a Purchaser so requests in writing, deliver to such Purchaser, without charge, (i) one copy of the following
documents, other than those documents available via EDGAR (and excluding, in each case, exhibits thereto): (A) its annual report
to its stockholders, if any (which annual report will contain financial statements audited in accordance with GAAP by a firm of certified
public accountants of recognized standing), (B) if not included in substance in its annual report to stockholders, its annual report
on Form 10-K (or similar form), (C) its definitive proxy statement with respect to its annual meeting of stockholders, (D) each
of its quarterly reports to its stockholders, and, if not included in substance in its quarterly reports to stockholders, its quarterly
report on Form 10-Q (or similar form), and (E) a copy of the Registration Statement; and (ii) if explicitly requested,
any exhibits filed with respect to the foregoing;

 

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(g)            upon
the occurrence of any event contemplated by Section 6.3(b)(iv), Amicus will use its commercially reasonable efforts to as
soon as reasonably practicable prepare a post-effective amendment to the Registration Statement or a supplement to the related prospectus,
or file any other required document so that, as thereafter delivered to the Purchasers, the prospectus will not include any untrue statement
of a material fact or omit to state any material fact necessary to make the statements therein, in the light of the circumstances under
which they were made, not misleading;

 

(h)            comply
in all material respects with all applicable rules and regulations of the SEC which could affect the sale of the Registrable Securities;

 

(i)             use
its commercially reasonable efforts to cause all Registrable Securities to be listed on each securities exchange or market, if any, on
which equity securities issued by Amicus have been listed;

 

(j)             use
its commercially reasonable efforts to take all other steps necessary to effect the registration of the Registrable Securities contemplated
hereby and to enable the Purchasers to sell Registrable Securities under Rule 144; and

 

(k)            permit
counsel for the Purchasers to review the Registration Statement and all amendments and supplements thereto, within two business days prior
to the filing thereof with the SEC;

 

provided
that, in the case of clause (k) above, Amicus will not be required to delay the filing of the Registration Statement or any amendment
or supplement thereto to incorporate any comments to the Registration Statement or any amendment or supplement thereto by or on behalf
of any Purchaser if such comments would require a delay in the filing of such Registration Statement, amendment or supplement, as the
case may be.

 

6.4           Furnishing
Information.

 

It shall be a condition precedent
to the obligations of Amicus to take any action pursuant to Section 6.1 that each of the selling Holders shall furnish to
Amicus such information regarding themselves, the Registrable Securities held by them and the intended method of disposition of such securities
as shall be legally required under the Securities Act or otherwise required by the SEC to effect the registration of their Registrable
Securities.

 

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6.5           Indemnification;
Contribution.

 

(a)           Amicus
shall indemnify and hold harmless each Holder (including the employees, agents, representatives, officers and directors of each Purchaser
and its Affiliates) (each a “Purchaser Indemnitee”) from and against any and all losses, claims, damages, liabilities
and expenses (including reasonable costs of investigation) arising out of or based upon any untrue, or allegedly untrue, statement of
a material fact contained in any Registration Statement, prospectus or preliminary prospectus or notification or offering circular prepared
by Amicus in connection with the registration and/or offering of the Registrable Securities (as amended or supplemented if Amicus shall
have furnished any amendments or supplements thereto) or arising out of or based upon any omission or alleged omission to state therein
a material fact required to be stated therein or necessary to make the statements therein not misleading, except insofar as the same are
caused by or contained in any information concerning such Holder furnished in writing to Amicus by such Holder specifically and expressly
for inclusion in such document.

 

(b)            Each
Holder shall indemnify and hold harmless Amicus, and its respective directors, officers, employees and each Person who controls Amicus
(within the meaning of the Securities Act and the Exchange Act) from and against any and all losses, claims, damages, liabilities and
expenses (including reasonable costs of investigation) arising out of or based upon any untrue, or allegedly untrue, statement of a material
fact contained in any Registration Statement, prospectus or preliminary prospectus or notification or offering circular prepared by Amicus
in connection with the registration and/or offering of the Registrable Securities (as amended or supplemented if Amicus shall have furnished
any amendments or supplements thereto) or arising out of or based upon any omission or alleged omission to state therein a material fact
required to be stated therein or necessary to make the statements therein not misleading, if such statement or omission was made in reliance
upon and in conformity with any information concerning such Holder furnished in writing to Amicus by such Holder specifically and expressly
for use in the preparation of such document; provided, however, that in no event shall any indemnity under this Section 6.5(b) be
greater in amount than the aggregate dollar amount of the proceeds received by all of the Purchasers upon the sale of such Registrable
Securities.

 

(c)            Each
Person entitled to indemnification hereunder (the “Indemnified Party”) agrees to give prompt written notice
to the indemnifying party (the “Indemnifying Party”) after the receipt by the Indemnified Party of any written
notice of the commencement of any action, suit, proceeding or investigation or threat thereof made in writing for which the Indemnified
Party intends to claim indemnification or contribution pursuant to the Transaction Documents; provided, however, that the failure
to so notify the Indemnifying Party shall not relieve the Indemnifying Party of any liability that it may have to the Indemnified Party
hereunder unless, and only to the extent that, such failure results in the Indemnifying Party’s forfeiture of substantive rights
or defenses. If notice of commencement of any such action is given to the Indemnifying Party as above provided, the Indemnifying Party
shall be entitled to participate in and, to the extent it may wish, jointly with any other Indemnifying Party similarly notified, to assume
the defense of such action at its own expense, with counsel chosen by it and reasonably satisfactory to such Indemnified Party. The Indemnified
Party shall have the right to employ separate counsel in any such action and participate in the defense thereof, but the fees and expenses
of such counsel (other than reasonable costs of investigation) shall be paid by the Indemnified Party unless (i) the Indemnifying
Party agrees to pay the same, (ii) the Indemnifying Party fails to assume the defense of such action with counsel reasonably satisfactory
to the Indemnified Party in its reasonable judgment or (iii) the named parties to any such action (including any impleaded parties)
have been advised by such counsel that either (x) representation of such Indemnified Party and the Indemnifying Party by the same
counsel would be inappropriate under applicable standards of professional conduct or (y) there may be one or more legal defenses
available to it which are different from or additional to those available to the Indemnifying Party. In either of such cases, the Indemnifying
Party shall not have the right to assume the defense of such action on behalf of such Indemnified Party. No Indemnifying Party shall be
liable for any settlement entered into without its written consent (other than in the case where the Indemnifying Party is unconditionally
released from liability and its rights are not adversely effected), which consent shall not be unreasonably withheld.

 

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(d)            If
the indemnification provided for in this Section 6.5 from the Indemnifying Party pursuant to applicable law is unavailable
to an Indemnified Party hereunder in respect of any losses, claims, damages, liabilities or expenses referred to therein, then the Indemnifying
Party, in lieu of indemnifying such Indemnified Party, shall contribute to the amount paid or payable by such Indemnified Party as a result
of such losses, claims, damages, liabilities or expenses in such proportion as is appropriate to reflect the relative fault of the Indemnifying
Party and Indemnified Party in connection with the actions which resulted in such losses, claims, damages, liabilities or expenses, as
well as any other relevant equitable considerations. The relative faults of such Indemnifying Party and Indemnified Party shall be determined
by reference to, among other things, whether any action in question, including any untrue or alleged untrue statement of a material fact
or omission or alleged omission to state a material fact, has been made by, or relates to information supplied by, such Indemnifying Party
or Indemnified Party, and the parties’ relative intent, Knowledge, access to information and opportunity to correct or prevent such
action. The amount paid or payable by a party as a result of the losses, claims, damages, liabilities and expenses referred to above shall
be deemed to include, subject to the limitations set forth in Sections 6.5(a), (b) and (c), any legal or other
fees, charges or expenses reasonably incurred by such party in connection with any investigation or proceeding. The parties hereto agree
that it would not be just and equitable if contribution pursuant to this Section 6.5(d) were determined by pro rata allocation
or by any other method of allocation which does not take account of the equitable considerations referred to in the immediately preceding
paragraph. No Person guilty of an intentional or fraudulent misrepresentation (within the meaning of Section 11(f) of the Securities
Act) shall be entitled to contribution from any Person.

 

6.6           Rule 144
Reporting. In order to make the benefits of the rules and regulations of the SEC that may permit the sale of the Registrable
Securities to the public without registration available to the Holders, Amicus agrees to use commercially reasonable efforts to:

 

(a)            make
and keep public information available, as those terms are understood and defined in Rule 144(c)(1) or any similar or analogous
rule promulgated under the Securities Act, at all times after the SPA Effective Date;

 

(b)            file
with the SEC, in a timely manner, all reports and other documents required of Amicus under the Exchange Act; and

 

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(c)            so
long as any Holder owns any Registrable Securities, furnish such Holders forthwith upon request: (i) a written statement by Amicus
as to its compliance with the reporting requirements of Rule 144 under the Securities Act, and of the Exchange Act; (ii) a copy
of the most recent annual or quarterly report of Amicus; and (iii) such other reports and documents as a Holder may reasonably request
in availing itself of any rule of regulation of the SEC allowing it to sell any such securities without registration.

 

6.7           Assignment
of Registration Rights. The rights and obligations under this Section 6 may only be assigned by a Holder to a transferee
or assignee of Registrable Securities that is (a) an Affiliate or (b) a successor (by operation of law or otherwise) to substantially
all the business or assets of such Holder; provided, however, that such attempted assignment shall be void unless (i) such
Holder, within 30 days after such transfer, furnishes to Amicus written notice of the name and address of such transferee or assignee
and the securities with respect to which such registration rights are being assigned, and (ii) such transferee agrees to be subject
to all obligations and restrictions with respect to the Registrable Securities set forth in this Agreement.

 

7.             Stock
Ownership Governance.

 

7.1           Lock-Up
Period. Excluding any transfers or intra-company disposal of the Shares between a Purchaser and any of its Affiliates, for a period
of sixty (60) days following the SPA Effective Date (the “Lock-Up Period”), each Purchaser shall not, and shall
cause any other Holder not to, without the prior written consent of Amicus, sell, contract to sell, pledge or otherwise dispose of, directly
or indirectly, any Shares or enter into a transaction which would have the same effect. For the avoidance of doubt, this Section 7.1
shall only apply to Shares purchased pursuant to this Agreement and shall not impose any restrictions on any other securities of Amicus
owned by the Purchaser.

 

7.2           Remedies.
Without prejudice to the rights and remedies otherwise available to the parties, Amicus shall be entitled to equitable relief by way of
injunction if any Purchaser or any other Holder breaches or threatens to breach any of the provisions of this Section 7.

 

8.             Covenants.

 

8.1           Covenant
of Amicus.

 

(a)            Amicus
hereby covenants and agrees that it shall take all necessary and appropriate actions to ensure that it shall have available under its
certificate of incorporation as in effect at the Closing sufficient authorized but unissued shares of its Common Stock to issue and sell
to Purchasers all of the Shares.

 

(b)           From
the date hereof until such time as the Shares have been sold pursuant to Rule 144 or are eligible for resale under Rule 144(b)(1) or
any successor provision, Amicus will use commercially reasonable efforts to continue the listing and trading of its Common Stock on Nasdaq
and, in accordance, therewith, will use commercially reasonable efforts to comply in all respects with Amicus’s reporting, filing
and other obligations under the bylaws or rules of such market or exchange, as applicable.

 

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(c)            Amicus
shall not, and shall use its commercially reasonable efforts to ensure that no controlled Affiliate of Amicus shall, sell, offer for sale
or solicit offers to buy or otherwise negotiate in respect of any security (as defined in Section 2 of the Securities Act) that will
be integrated with the offer or sale of the Shares in a manner that would require the registration under the Securities Act of the sale
of the Shares to the Investors. Amicus shall not take any action or steps that would adversely affect reliance by Amicus in any material
respect on Section 4(a)(2) for the exemption from registration for the transactions contemplated hereby or require registration
of the Shares under the Securities Act.

 

8.2           Removal
of Legends. In connection with any sale or disposition of the Shares by a Purchaser pursuant to Rule 144 or pursuant to any other
exemption under the Securities Act such that the Purchaser acquires freely tradable shares and upon compliance by the Purchaser with the
requirements of this Agreement, if requested in writing by the Purchaser, Amicus shall use its commercially reasonable efforts to request
that the transfer agent for the Common Stock (the “Transfer Agent”) remove any restrictive legends related to
the book entry account holding such Shares and make a new, unlegended entry for such book entry Shares sold or disposed of without restrictive
legends within two (2) Trading Days of receipt of such request from the Purchaser. Upon the earliest of such time as the Shares (i) have
been registered for resale pursuant to an effective registration statement, (ii) have been sold pursuant to Rule 144 or (iii) are
eligible for resale under Rule 144(b)(1) or any successor provision, Amicus shall (A) deliver to the Transfer Agent irrevocable
instructions that the Transfer Agent shall make a new, unlegended entry for such book entry Shares, and (B) cause its counsel to
deliver to the Transfer Agent one or more opinions to the effect that the removal of such legends in such circumstances may be effected
under the Securities Act. Amicus shall be responsible for the fees of its Transfer Agent and all DTC fees associated with such issuance.

 

9.             Miscellaneous.

 

9.1           Governing
Law. All questions concerning the construction, validity, enforcement and interpretation of the Transaction Documents shall be governed
by and construed and enforced in accordance with the internal laws of the State of Delaware, without regard to the principles of conflicts
of law thereof. Each Party hereby irrevocably waives personal service of process and consents to process being served in any such suit,
action or proceeding by mailing a copy thereof via registered or certified mail or overnight delivery (with evidence of delivery) to such
Party at the address in effect for notices to it under the Transaction Documents and agrees that such service shall constitute good and
sufficient service of process and notice thereof. Nothing contained herein shall be deemed to limit in any way any right to serve process
in any other manner permitted by law.

 

9.2           Execution.
This Agreement may be executed in two or more counterparts, all of which when taken together shall be considered one and the same agreement
and shall become effective when counterparts have been signed by the Parties and delivered to the other Parties, it being understood that
the Parties need not sign the same counterpart. In the event that any signature is delivered by e-mail delivery of a “.pdf”
format data file, such signature shall create a valid and binding obligation of the party executing (or on whose behalf such signature
is executed) with the same force and effect as if such “.pdf” signature page were an original thereof.

 

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9.3           Public
Statements. Amicus shall no later than the close of business on the date immediately following the date hereof, either issue a press
release or file a Current Report on Form 8-K disclosing the material terms of the transactions contemplated hereby and any other
material, nonpublic information that Amicus may have provided to any Purchaser at any time prior thereto promptly following the execution
and delivery hereof, which shall have been previously reviewed by counsel for the Purchasers (the “Press Release”).
Amicus shall not include the name of any Purchaser in the Press Release or any other public announcement without the prior written consent
of such Purchaser. Subject to the foregoing, any statement to the public regarding this the Transaction Documents shall be approved in
advance by Amicus and the Purchasers, except as otherwise required by law, rule, regulation, legal process or applicable SEC Guidance.

 

9.4           Successors
and Assigns. This Agreement shall be binding upon and inure to the benefit of the Parties and their successors and permitted assigns.
Amicus may not assign this Agreement or any rights or obligations hereunder without the prior written consent of Purchasers purchasing
at least 85% of the Shares issuable hereunder. Subject to Section 6.7, any Purchaser may assign any or all of its rights under
this Agreement to any Person to whom such Purchaser assigns or transfers any Shares, provided such transferee agrees in writing to be
bound, with respect to the transferred Shares, by the provisions of the Transaction Documents that apply to the “Purchasers.”

 

9.5           Entire
Agreement. The Transaction Documents, together with the exhibits and schedules hereto, contain the entire understanding of the Parties
with respect to the subject matter hereof and thereof and supersede all prior agreements and understandings, oral or written, with respect
to such matters (other than confidentiality agreements to which Amicus is a party to with the Purchasers), which the Parties acknowledge
have been merged into such documents, exhibits and schedules.

 

9.6           Separability.
If any term, provision, covenant or restriction of this Agreement is held by a court of competent jurisdiction to be invalid, illegal,
void or unenforceable, the remainder of the terms, provisions, covenants and restrictions set forth herein shall remain in full force
and effect and shall in no way be affected, impaired or invalidated, and the Parties hereto shall use their commercially reasonable efforts
to find and employ an alternative means to achieve the same or substantially the same result as that contemplated by such term, provision,
covenant or restriction. It is hereby stipulated and declared to be the intention of the Parties that they would have executed the remaining
terms, provisions, covenants and restrictions without including any of such that may be hereafter declared invalid, illegal, void or unenforceable.

 

9.7           Rescission
and Withdrawal Right. Notwithstanding anything to the contrary contained in (and without limiting any similar provisions of) any of
the other Transaction Documents, whenever any Purchaser exercises a right, election, demand or option under a Transaction Document and
Amicus does not timely perform its related obligations within the periods therein provided, then such Purchaser may rescind or withdraw,
in its sole discretion from time to time upon written notice to Amicus, any relevant notice, demand or election in whole or in part without
prejudice to its future actions and rights.

 

9.8           Replacement
of Shares. If any certificate or instrument evidencing any Shares is mutilated, lost, stolen or destroyed, Amicus shall issue or cause
to be issued in exchange and substitution for and upon cancellation thereof (in the case of mutilation), or in lieu of and substitution
therefor, a new certificate or instrument, but only upon receipt of evidence reasonably satisfactory to Amicus of such loss, theft or
destruction. The applicant for a new certificate or instrument under such circumstances may also be required to pay a customary bond and
any reasonable third-party costs associated with the issuance of such replacement Shares.

 

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9.9           Remedies.
In addition to being entitled to exercise all rights provided herein or granted by law, including recovery of damages, each of the Purchasers
and Amicus will be entitled to specific performance under the Transaction Documents. The parties agree that monetary damages may not be
adequate compensation for any loss incurred by reason of any breach of obligations contained in the Transaction Documents and hereby agrees
to waive and not to assert in any action for specific performance of any such obligation the defense that a remedy at law would be adequate.

 

9.10         Independent
Nature of Purchasers’ Obligations and Rights. The obligations of each Purchaser under any Transaction Document are several and
not joint with the obligations of any other Purchaser, and no Purchaser shall be responsible in any way for the performance or non-performance
of the obligations of any other Purchaser under any Transaction Document. Nothing contained herein or in any other Transaction Document,
and no action taken by any Purchaser pursuant hereto, shall be deemed to constitute the Purchasers as a partnership, an association, a
joint venture or any other kind of entity, or create a presumption that the Purchasers are in any way acting in concert or as a group
with respect to such obligations or the transactions contemplated by the Transaction Documents. Each Purchaser shall be entitled to independently
protect and enforce its rights, including without limitation, the rights arising out of this Agreement or out of the other Transaction
Documents, and it shall not be necessary for any other Purchaser to be joined as an additional party in any proceeding for such purpose.
Each Purchaser has been represented by its own separate legal counsel in their review and negotiation of the Transaction Documents.

 

9.11         Amendment
and Waiver. No provision of this Agreement may be waived or amended except in a written instrument signed, in the case of an amendment,
by Amicus and Purchasers purchasing at least 85% of the Shares issuable hereunder or, in the case of a waiver, by the Party against whom
enforcement of any such waived provision is sought. No waiver of any default with respect to any provision, condition or requirement of
this Agreement shall be deemed to be a continuing waiver in the future or a waiver of any subsequent default or a waiver of any other
provision, condition or requirement hereof, nor shall any delay or omission of any party to exercise any right hereunder in any manner
impair the exercise of any such right.

 

9.12         Notices.
Any and all notices or other communications or deliveries required or permitted to be provided hereunder shall be in writing and shall
be deemed given and effective on the earliest of (a) the date of transmission, if such notice or communication is delivered via email
at the email address set forth on the signature pages attached hereto prior to 5:30 p.m. (New York City time) on a Trading Day,
(b) the next Trading Day after the date of transmission, if such notice or communication is delivered via email at the email address
set forth on the signature pages attached hereto on a day that is not a Trading Day or later than 5:30 p.m. (New York City time)
on any Trading Day, (c) the second Trading Day following the date of mailing, if sent by U.S. nationally recognized overnight courier
service, or (d) upon actual receipt by the party to whom such notice is required to be given. The address for such notices and communications
shall be as set forth on the signature pages attached hereto.

 

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9.13         Fees
and Expenses. Except as expressly set forth in the Transaction Documents to the contrary, each Party shall pay the fees and expenses
of its advisers, counsel, accountants and other experts, if any, and all other expenses incurred by such party incident to the negotiation,
preparation, execution, delivery and performance of this Agreement. Amicus shall pay all transfer agent fees, stamp taxes and other taxes
and duties levied in connection with the delivery of any Shares to the Purchasers.

 

9.14         Titles
and Subtitles. The headings herein are for convenience only, do not constitute a part of this Agreement and shall not be deemed to
limit or affect any of the provisions hereof.

 

9.15         Counterparts;
Effectiveness. This Agreement may be executed in any number of counterparts, each of which shall be deemed an original, but all of
which together shall constitute one instrument. This Agreement shall become effective when each Party hereto shall have received counterparts
thereof signed and delivered (by telecopy or other electronic means) by the other Parties hereto. Counterparts may be delivered via facsimile,
electronic mail (including any electronic signature covered by the U.S. federal ESIGN Act of 2000, Uniform Electronic Transactions Act,
the Electronic Signatures and Records Act or other applicable law, e.g., www.docusign.com) or other transmission method and any counterpart
so delivered shall be deemed to have been duly and validly delivered and be valid and effective for all purposes.

 

9.16         Construction.
The Parties agree that each of them and/or their respective counsel has reviewed and had an opportunity to revise the Transaction Documents
and, therefore, the normal rule of construction to the effect that any ambiguities are to be resolved against the drafting party
shall not be employed in the interpretation of the Transaction Documents or any amendments hereto.

 

9.17         No
Third-Party Beneficiaries. This Agreement is intended for the benefit of the Parties hereto and their respective successors and permitted
assigns and is not for the benefit of, nor may any provision hereof be enforced by, any other Person, except as otherwise set forth in
Section 6.5.

 

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This Securities Purchase Agreement is hereby executed
as of the date first above written.

 

	 	AMICUS:
	 	 
	 	Amicus Therapeutics, Inc.
	 	 
	 	By:	 /s/ Daphne Quimi
	 	 	Name:	Daphne Quimi
	 	 	Title:	Chief Financial Officer
	 	 
	 	Address:	3675 Market Street
	 	 	Philadelphia, PA 19104
	 	Email:	gcoffice@amicusrx.com

 

[Signature
Page to Securities Purchase Agreement]

 

    

     

    

 

	 	PURCHASER:
	 	 
	 	Avoro Life Sciences Fund LLC
	 	 
	 	By:	 /s/ Scott Epstein
	 	 	Name:	Scott
Epstein
	 	 	Title:	Partner, CFO &COO
	 	 	 	 
	 	Address:	110 Greene Street, Suite 800
	 	 	New York, New York 10012

 

[Signature
Page to Securities Purchase Agreement]

 

    

     

    

 

	 	PURCHASER:
	 	 
	 	Invus Public Equities, L.P.
	 	 
	 	By:	/s/
Khalil Barrage
	 	 	Name:	Khalil
Barrage
	 	 	Title:	Vice President of the General Partner
	 	 	 	 
	 	Address:	750 Lexington Ave, 30th FL
	 	 	New York, NY 10022

 

[Signature
Page to Securities Purchase Agreement]

 

    

     

    

 

	 	PURCHASER:
	 	 
	 	
    JANUS HENDERSON BIOTECH INNOVATION MASTER FUND LIMITED

     

    By: Janus Capital Management LLC, its investment advisor

	 	 
	 	By:	/s/
Andrew Acker
	 	 	Name:	Andrew
Acker
	 	 	Title:	Authorized Signatory
	 	 	 	 
	 	Address:	151 Detroit Street
	 	 	Denver, CO 80206

 

[Signature Page to Securities Purchase
Agreement]

 

    

     

    

 

	 	PURCHASER:
	 	 
	 	Sphera Biotech Master Fund LP
	 	 
	 	By:	/s/
Michelle Ross
	 	 	Name:	Michelle
Ross
	 	 	Title:	Portfolio Manager & Partner
	 	 	 	 
	 	Address:	PO Box 309, Ugland House, Grand
	 	 	Cayman, KY1-1104, Cayman Islands

 

[Signature Page to Securities Purchase
Agreement]

 

    

     

    

 

	 	PURCHASER:
	 	 
	 	Sphera Global Healthcare Master Fund
	 	 	 
	 	By:	/s/
Michelle Ross
	 	 	Name:	Michelle
Ross
	 	 	Title:	Portfolio Manager & Partner
	 	 
	 	Address:	PO Box 309, Ugland House, Grand
	 	 	Cayman, KY1-1104, Cayman Islands

 

[Signature Page to Securities Purchase
Agreement]

 

    

     

    

 

Schedule A

 

Purchaser Share Amounts

 

	Purchaser	 	Shares

 Purchased	 	 	Purchase Price

 (in $)	 
	Avoro Life Sciences Fund LLC	 	 	3,929,273	 	 	$	39,999,999.14	 
	Invus Public Equities, L.P.	 	 	2,946,955	 	 	$	30,000,001.90	 
	Janus Henderson Biotech Innovation Master Fund Limited	 	 	491,159	 	 	$	4,999,998.62	 
	Sphera Biotech Master Fund LP	 	 	211,198	 	 	$	2,149,996	 
	Sphera Global Healthcare Master Fund	 	 	279,961	 	 	$	2,850,003Exhibit 10.6

 

Execution Version

 

Investor Rights Agreement

 

This Investor Rights Agreement
(this “Agreement”), dated as of September 29, 2021, is among ARYA Sciences Acquisition Corp IV, a Cayman Islands exempted
company (the “Company”) and the other parties hereto identified as a “Holder” on the signature pages hereto
(each, a “Holder” and collectively, the “Holders”). Capitalized terms used but not defined herein
have the meanings assigned to them in the Business Combination Agreement dated as of the date hereof (the “Business Combination
Agreement”), among the Company, Amicus Therapeutics, Inc., a Delaware corporation (“Parent”), Amicus GT Holdings,
LLC, a Delaware limited liability company (“Amber GT”), and Caritas Therapeutics, LLC, a Delaware limited liability
company (“Caritas”).

 

WHEREAS, pursuant to the Business
Combination Agreement, among other things, on the Closing Date, (i) the Company will redomesticate as a Delaware corporation and change
its name from “ARYA Sciences Acquisition Corp IV to “Caritas Therapeutics, Inc.”, (ii) the Company will receive the
number of Common Units (as defined in the LLC Agreement (as defined below)) equal to the Net Outstanding ARYA Class A Shares determined
pursuant to the Business Combination Agreement, (iii) the Company will issue to Amber GT the number of ARYA Class B Shares equal to the
Transaction Equity Security Amount determined pursuant to the Business Combination Agreement and (iv) Amber GT will receive a number of
Common Units equal to the number of ARYA Class B Shares it receives on the Closing Date (the “Amber GT Units”), and
such Amber GT Units will be exchangeable for Common Stock (as defined below) from time to time pursuant to the terms of the LLC Agreement;

 

WHEREAS, in connection with
the consummation of the transactions contemplated by the Business Combination Agreement, Perceptive Life Sciences Master Fund Ltd., a
Cayman Islands exempted company (“Perceptive”), will be issued shares of Common Stock in a private placement transaction
pursuant to that certain Subscription Agreement, dated as of September 29, 2021;

 

WHEREAS, the Company, ARYA
Sciences Holdings IV, a Cayman Islands exempted limited company (the “Sponsor”), and the Independent Directors (as
defined herein, and, together with the Sponsor, the “Original Holders”) are parties to the Registration and Shareholder
Rights Agreement, dated as of March 2, 2021 (the “Prior Agreement”); and

 

WHEREAS, the parties to the
Prior Agreement desire to terminate the Prior Agreement and to provide for certain rights and obligations included herein and to include
Amber GT and Perceptive.

 

NOW, THEREFORE, in consideration
of the foregoing, the parties hereby agree as follows:

 

Article
I 

DEFINITIONS

 

Section 1.1.       
Definitions. For purposes of this Agreement, the following terms and variations thereof have the meanings set forth below:

 

“Adverse Disclosure”
shall mean any public disclosure of material non-public information, which disclosure, in the good faith judgment of the Board, after
consultation with outside counsel to the Company, (i) would be required to be made in any Registration Statement or Prospectus in order
for the applicable Registration Statement or Prospectus not to contain any untrue statement of a material fact or omit to state a material
fact necessary to make the statements contained therein (in the case of any prospectus and any preliminary prospectus, in the light of
the circumstances under which they were made) not misleading, (ii) would not be required to be made at such time if the Registration Statement
were not being filed, and (iii) the Company has a bona fide business purpose for not making such information public.

 

     

     

    

 

“Agreement”
shall have the meaning given in the Recitals.

 

“Amber GT”
shall have the meaning given in the Recitals.

 

“Amber GT Units”
shall have the meaning given in the Recitals.

 

“Block Trade”
means any non-marketed underwritten offering taking the form of a block trade to a financial institution, “qualified institutional
buyer” (as defined in Rule 144A under the Securities Act) or institutional “accredited” investor (as defined in Rule
501(a) of Regulation D under the Securities Act), bought deal, over-night deal or similar transaction through a broker, sales agent or
distribution agent, whether as agent or principal, that does not include “road show” presentations to potential investors
requiring substantial marketing effort from management over multiple days, the issuance of a “comfort letter” by the Company’s
auditors, or the issuance of a legal opinion by the Company’s legal counsel.

 

“Board”
shall mean the Board of Directors of the Company.

 

“Business Combination
Agreement” shall have the meaning given in the Recitals.

 

“Business Day”
means a day other than Saturday, Sunday or other day on which commercial banks in New York, New York are authorized or required by law
to close.

 

“Caritas”
shall have the meaning given in the Recitals.

 

“Change in Control”
means the transfer (whether by tender offer, merger, stock purchase, consolidation or other similar transaction), in one transaction or
a series of related transactions, to a person or group of affiliated persons of the Company’s voting securities if, after such transfer,
such person or group of affiliated persons would hold more than 50% of outstanding voting securities of the Company (or surviving entity)
or would otherwise have the power to control the board of directors of the Company or to direct the operations of the Company.

 

“Commission”
means the Securities and Exchange Commission.

 

“Common Stock”
means, after giving effect to the Domestication, the Company’s Class A common stock, par value $0.0001 per share.

 

“Company”
shall have the meaning given in the Recitals.

 

    2 

     

    

 

“Demand Registration”
shall have the meaning given in subsection 2.1.1.

 

“Demand Requesting
Holder” shall have the meaning given in subsection 2.1.1.

 

“Demanding Holders”
shall have the meaning given in subsection 2.1.1.

 

“Exchange Act”
shall mean the Securities Exchange Act of 1934, as it may be amended from time to time.

 

“Form S-1”
means a Registration Statement on Form S-1 or any comparable successor form or forms thereto.

 

“Form S-3”
means a Registration Statement on Form S-3 or any comparable successor form or forms thereto.

 

“Holders”
shall have the meaning given in the Recitals.

 

“Independent Directors”
means Todd Wider, Michael Henderson and Leslie Trigg.

 

“Insider Letter”
shall mean that certain letter agreement, dated as of February 25, 2021, by and among the Company, the Sponsor and each of the other parties
thereto.

 

“Liquidation Event”
shall mean any of the following : (i) the acquisition of the Company by another entity by means of any transaction or series of related
transactions to which the Company is party (including, without limitation, any stock acquisition, reorganization, sale of voting control,
merger or consolidation but excluding any sale of stock for capital raising purposes) other than a transaction or series of related transactions
in which the holders of the voting securities of the Company outstanding immediately prior to such transaction or series of related transactions
retain, immediately after such transaction or series of related transactions, as a result of shares in the Company held by such holders
prior to such transaction or series of related transactions, at least a majority of the total voting power represented by the outstanding
voting securities of the Company or such other surviving or resulting entity (or if the Company or such other surviving or resulting entity
is a wholly-owned subsidiary immediately following such acquisition, its parent); (ii) a sale, lease, transfer, exclusive license or other
disposition of all or substantially all of the assets of the Company and its subsidiaries taken as a whole by means of any transaction
or series of related transactions, except where such sale, lease, transfer, exclusive license or other disposition is to a wholly-owned
subsidiary of the Company; or (iii) any liquidation, dissolution or winding up of the Company, whether voluntary or involuntary.

 

“LLC Agreement”
shall mean the Amended and Restated Limited Liability Agreement of Caritas, as in effect following the consummation of the transactions
contemplated by the Business Combination Agreement, and as the same may be amended from time to time.

 

“Maximum Number of
Securities” shall have the meaning given in subsection 2.1.4.

 

“Misstatement”
shall mean an untrue statement of a material fact or an omission to state a material fact required to be stated in a Registration Statement
or Prospectus, or necessary to make the statements in a Registration Statement or Prospectus in the light of the circumstances under which
they were made not misleading.

 

    3 

     

    

 

“New Registration
Statement” shall have the meaning given in subsection 2.3.4.

 

“Original Holders”
shall have the meaning given in the Recitals.

 

“Parent”
shall have the meaning given in the Recitals.

 

“Perceptive Holders”
means the Sponsor and Perceptive.

 

“Permitted Transferee”
shall have the meaning given in subsection 7.3.2.

 

“Piggyback Registration”
shall have the meaning given in subsection 2.3.1.

 

“PIPE Shares”
means shares of Common Stock purchased pursuant to those certain Subscription Agreements between certain Holders and the Company dated
on or about September 29, 2021.

 

“Prior Agreement”
shall have the meaning given in the Recitals.

 

“Private Placement
Shares Purchase Agreement” shall mean that certain Private Placement Shares Purchase Agreement, dated as of February 25, 2021,
by and between the Company and the Sponsor.

 

“Pro Rata”
shall have the meaning given in subsection 2.1.4.

 

“Prospectus”
shall mean the prospectus included in any Registration Statement, as supplemented by any and all prospectus supplements and as amended
by any and all post-effective amendments and including all material incorporated by reference in such prospectus.

 

“Registrable Security”,
 “Registrable Securities” shall mean (a) any outstanding share of Common Stock (including the shares of Common Stock
issued or issuable upon the exchange of any Amber GT Units pursuant to and in accordance with the LLC Agreement or the exercise of any
other equity security) held by a Holder as of the closing of the transactions contemplated by the Business Combination Agreement (including,
without limitation, the PIPE Shares and any shares of Common Stock issued pursuant to the Business Combination Agreement) and (b) any
other equity security of the Company issued or issuable with respect to any such share of Common Stock by way of a stock dividend or stock
split or in connection with a combination of shares, recapitalization, merger, consolidation or reorganization; provided, however,
that, as to any particular Registrable Security, such securities shall cease to be Registrable Securities when: (A) a Registration Statement
with respect to the sale of such securities shall have become effective under the Securities Act and such securities shall have been sold,
transferred, disposed of or exchanged in accordance with such Registration Statement; (B) such securities shall have been otherwise transferred,
new certificates for such securities not bearing a legend restricting further transfer shall have been delivered by the Company to the
transferee, and subsequent public distribution of such securities shall not require registration under the Securities Act; (C) such securities
shall have ceased to be outstanding; or (D) such securities have been sold to, or through, a broker, dealer or underwriter in a public
distribution or other public securities transaction.

 

    4 

     

    

 

“Registration”
shall mean a registration effected by preparing and filing a registration statement or similar document in compliance with the requirements
of the Securities Act, and the applicable rules and regulations promulgated thereunder, and such registration statement becoming effective.

 

“Registration Expenses”
shall mean the out-of-pocket expenses of a Registration or Underwritten Offering, including, without limitation, the following:

 

(A)       all
registration and filing fees (including fees with respect to filings required to be made with the Financial Industry Regulatory Authority,
Inc.) and any securities exchange on which the Common Stock is then listed;

 

(B)       fees
and expenses of compliance with securities or Blue Sky laws (including reasonable fees and disbursements of counsel for the Underwriters
in connection with Blue Sky qualifications of Registrable Securities);

 

(C)       printing,
messenger, telephone and delivery expenses;

 

(D)       fees
and disbursements of counsel for the Company;

 

(E)       reasonable
fees and disbursements of all independent registered public accountants of the Company incurred specifically in connection with such Registration
or Underwritten Offering; and

 

(F)       reasonable
fees and expenses of one (1) legal counsel selected by the majority-in-interest of the Demanding Holders or the majority-in interest of
the Takedown Requesting Holders (including if such Underwritten Takedown is in the form of a Block Trade), as applicable.

 

“Registration Statement”
shall mean any registration statement that covers the Registrable Securities pursuant to the provisions of this Agreement, including the
Prospectus included in such registration statement, amendments (including post-effective amendments) and supplements to such registration
statement, and all exhibits to and all material incorporated by reference in such registration statement.

 

“Requesting Holder”
shall have the meaning given in subsection 2.3.5.

 

“Resale Shelf Registration
Statement” shall have the meaning given in subsection 2.3.1.

 

“Securities Act”
shall mean the Securities Act of 1933, as amended from time to time.

 

“Selling Holders”
means any Holder electing to sell any of its Registrable Securities in a Registration.

 

    5 

     

    

 

“SEC Guidance”
shall have the meaning given in subsection 2.3.4.

 

“Sponsor”
shall have the meaning given in the Recitals.

 

“Takedown Requesting
Holder” shall have the meaning given in subsection 2.3.5.

 

“Transfer”
means to, directly or indirectly, sell, transfer, assign, pledge, encumber, hypothecate or similarly dispose of, either voluntarily or
involuntarily, or to enter into any contract, option or other arrangement or understanding with respect to the sale, transfer, assignment,
pledge, encumbrance, hypothecation or similar disposition of, any interest owned by a person or any interest (including a beneficial interest)
in, or the ownership, control or possession of, any interest owned by a person.

 

“Underwriter”
shall mean a securities dealer who purchases any Registrable Securities as principal in an Underwritten Offering and not as part of such
dealer’s market-making activities.

 

“Underwritten Registration”
or “Underwritten Offering” shall mean a Registration in which securities of the Company are sold to an Underwriter
in a firm commitment underwriting for distribution to the public, including for the avoidance of doubt an Underwritten Shelf Takedown.

 

“Underwritten Shelf
Takedown” shall have the meaning given in subsection 2.3.5.

 

Article
II 

REGISTRATION

 

Section 2.1.       
Demand Registration.

 

2.1.1      
Request for Registration. Subject to the provisions of subsection 2.1.4 and Section 2.4 hereof,
at any time and from time to time (but subject to Article V), (i) Amber GT or (ii) the Perceptive Holders holding at least a majority
in interest of the then-outstanding number of Registrable Securities held by all Perceptive Holders (as the case may be, the “Demanding
Holders”), may make a written demand for Registration of all or part of their Registrable Securities on Form S-3 (or, if Form
S-3 is not available to be used by the Company at such time, on Form S-1 or another appropriate form permitting Registration of such Registrable
Securities for resale by such Demanding Holders), which written demand shall describe the amount and type of securities to be included
in such Registration and the intended method(s) of distribution thereof (such written demand a “Demand Registration”).
The Company shall, within ten (10) days of the Company’s receipt of the Demand Registration, notify, in writing, all other Holders
of Registrable Securities of such demand, and each Holder of Registrable Securities who thereafter wishes to include all or a portion
of such Holder’s Registrable Securities in a Registration pursuant to a Demand Registration (each such Holder that includes all
or a portion of such Holder’s Registrable Securities in such Registration, a “Demand Requesting Holder”) shall
so notify the Company, in writing, within five (5) days after the receipt by the Holder of the notice from the Company. Upon receipt by
the Company of any such written notification from a Demand Requesting Holder(s) to the Company, such Demand Requesting Holder(s) shall
be entitled to have their Registrable Securities included in a Registration pursuant to a Demand Registration and the Company shall effect,
as soon thereafter as practicable, but not more than thirty (30) days immediately after the Company’s receipt of the Demand Registration,
the Registration of all Registrable Securities requested by the Demanding Holders and Demand Requesting Holders pursuant to such Demand
Registration; provided, that the Company shall not be obligated to effect any Registration under this subsection
2.1.1 if the Demanding Holders and Demand Requesting Holders propose to sell Registrable Securities with aggregate proceeds of
less than $25,000,000.

 

    6 

     

    

 

2.1.2      
Effective Registration. Notwithstanding the provisions of subsection 2.1.1 above or any other part of this
Agreement, a Registration pursuant to a Demand Registration shall not count as a Registration unless and until (i) the Registration Statement
filed with the Commission with respect to a Registration pursuant to a Demand Registration has been declared effective by the Commission
and (ii) the Company has complied with all of its obligations under this Agreement with respect thereto; provided, however,
that if, after such Registration Statement has been declared effective, an offering of Registrable Securities in a Registration pursuant
to a Demand Registration is subsequently interfered with by any stop order or injunction of the Commission, federal or state court or
any other governmental agency, the Registration Statement with respect to such Registration shall be deemed not to have been declared
effective for purposes of counting Registrations under subsection 2.1.1 above unless and until (i) such stop order or
injunction is removed, rescinded or otherwise terminated, and (ii) a majority-in-interest of the Demanding Holders initiating such Demand
Registration thereafter affirmatively elect to continue with such Registration and accordingly notify the Company in writing, but in no
event later than five (5) days, of such election; provided, further, however, that the Company shall
not be obligated or required to file another Registration Statement until the Registration Statement that has been previously filed with
respect to a Registration pursuant to a Demand Registration becomes effective or has been terminated.

 

2.1.3      
Underwritten Offering. Subject to the provisions of subsection 2.1.4 and Section 2.4 hereof,
if a majority-in-interest of the Demanding Holders advise the Company as part of their Demand Registration that the offering of the Registrable
Securities pursuant to such Demand Registration shall be in the form of an Underwritten Offering, then the right of such Demanding Holder
or Demand Requesting Holder (if any) to include its Registrable Securities in such Registration shall be conditioned upon such Holder’s
participation in such Underwritten Offering and the inclusion of such Holder’s Registrable Securities in such Underwritten Offering
to the extent provided herein. All such Holders proposing to distribute their Registrable Securities through an Underwritten Offering
under this subsection 2.1.3 shall enter into an underwriting agreement in customary form with the Underwriter(s) selected
for such Underwritten Offering by a majority-in-interest of the Demanding Holders, such Underwriter(s) to be reasonably acceptable to
the Company.

 

2.1.4      
Reduction of Underwritten Offering. If the managing Underwriter or Underwriters in an Underwritten Registration pursuant
to a Demand Registration, in good faith, advises the Company, the Demanding Holders and the Demand Requesting Holders (if any) in writing
that the dollar amount or number of Registrable Securities that the Demanding Holders and the Demand Requesting Holders (if any) desire
to sell, taken together with all other Common Stock or other equity securities that the Company desires to sell and the Common Stock,
if any, as to which a Registration has been requested pursuant to separate written contractual piggy-back registration rights held by
any other stockholders who desire to sell, exceeds the maximum dollar amount or maximum number of equity securities that can be sold in
the Underwritten Offering without adversely affecting the proposed offering price, the timing, the distribution method, or the probability
of success of such offering (such maximum dollar amount or maximum number of such securities, as applicable, the “Maximum Number
of Securities”), then the Company shall include in such Underwritten Offering, as follows: (i) first, the Registrable Securities
of the Demanding Holders and the Demand Requesting Holders (if any) (pro rata based on the respective number of Registrable Securities
that each Demanding Holder and Demand Requesting Holder (if any) has requested be included in such Underwritten Registration and the aggregate
number of Registrable Securities that the Demanding Holders and Demand Requesting Holders have requested be included in such Underwritten
Registration (such proportion is referred to herein as “Pro Rata”)) that can be sold without exceeding the Maximum
Number of Securities; (ii) second, to the extent that the Maximum Number of Securities has not been reached under the foregoing clause
(i), Common Stock or other equity securities that the Company desires to sell, which can be sold without exceeding the Maximum Number
of Securities; and (iii) third, to the extent that the Maximum Number of Securities has not been reached under the foregoing clauses (i)
and (ii), Common Stock or other equity securities of other persons or entities that the Company is obligated to register in a Registration
pursuant to separate written contractual arrangements with such persons and that can be sold without exceeding the Maximum Number of Securities.

 

    7 

     

    

 

2.1.5      
Demand Registration Withdrawal. Amber GT or a majority-in-interest of the Perceptive Holders, as the case may be, in the
case of a Registration under subsection 2.1.1 initiated by Amber GT or the Perceptive Holders, as the case may be, or
any Demand Requesting Holders (if any) shall have the right to withdraw from a Registration pursuant to such Demand Registration for any
or no reason whatsoever upon written notification to the Company and the Underwriter(s) (if any) of their intention to withdraw from such
Registration prior to the effectiveness of the Registration Statement filed with the Commission with respect to the Registration of their
Registrable Securities pursuant to such Demand Registration (or after such Registration Statement has been declared effective and is subsequently
interfered with by any stop order or injunction of the Commission, federal or state court or any other governmental agency).

 

Section 2.2.       
Piggyback Registration.

 

2.2.1      
Piggyback Rights. If the Company proposes to file a Registration Statement under the Securities Act with respect to an offering
of equity securities, or securities or other obligations exercisable or exchangeable for, or convertible into equity securities, for its
own account or for the account of stockholders of the Company (other than pursuant to Sections 2.1 and 2.3 of
this Agreement), other than a Registration Statement (i) filed in connection with any employee stock option or other benefit plan,
(ii) for an exchange offer or offering of securities solely to the Company’s existing stockholders, (iii) for an offering of debt
that is convertible into equity securities of the Company, (iv) filed on Form S-4 related to any merger, acquisition or business combination,
or (v) for a dividend reinvestment plan, then the Company shall give written notice of such proposed filing to all of the Holders of Registrable
Securities as soon as practicable but not less than ten (10) days before the anticipated filing date of such Registration Statement or
applicable Prospectus, which notice shall (A) describe the amount and type of securities to be included in such offering, the intended
method(s) of distribution, and the name of the proposed managing Underwriter(s), if any, in such offering, and (B) offer to all of the
Holders of Registrable Securities the opportunity to register the sale of such number of Registrable Securities as such Holders may request
in writing within five (5) days after receipt of such written notice (such Registration a “Piggyback Registration”).
The Company shall, in good faith, cause such Registrable Securities to be included in such Piggyback Registration and shall use its commercially
reasonable efforts to cause the managing Underwriter(s) of a proposed Underwritten Offering to permit the Registrable Securities requested
by the Holders pursuant to this subsection 2.2.1 to be included in a Piggyback Registration on the same terms and conditions
as any similar securities of the Company included in such Registration and to permit the sale or other disposition of such Registrable
Securities in accordance with the intended method(s) of distribution thereof. All such Holders proposing to distribute their Registrable
Securities through an Underwritten Offering under this subsection 2.2.1 shall enter into an underwriting agreement in
customary form with the Underwriter(s) selected for such Underwritten Offering by the Company.

 

    8 

     

    

 

2.2.2      
Reduction of Piggyback Registration. If the managing Underwriter(s) in an Underwritten Registration that is to be a Piggyback
Registration, in good faith, advises the Company and the Holders of Registrable Securities participating in the Piggyback Registration
in writing that the dollar amount or number of shares of Common Stock that the Company desires to sell, taken together with (i) the shares
of Common Stock, if any, as to which Registration has been demanded pursuant to separate written contractual arrangements with persons
or entities other than the Holders of Registrable Securities hereunder, (ii) the Registrable Securities as to which registration has been
requested pursuant to Section 2.2.1 hereof, and (iii) the shares of Common Stock, if any, as to which Registration has
been requested pursuant to separate written contractual piggy-back registration rights of other stockholders of the Company, exceeds the
Maximum Number of Securities, then:

 

		(i)	If the Registration is undertaken for the Company’s account (which, for the avoidance of doubt,
shall not include an offering of securities by the Company for the purpose of delivering cash to Amber GT or its transferee in connection
with an exchange of Amber GT Units pursuant to the LLC Agreement, such a Registration being considered to be a Registration by Amber GT
or its transferee, such Registration to be subject to the reduction procedures set forth in subsection 2.1.4 or subsection 2.3.6, as applicable),
the Company shall include in any such Registration (A) first, Common Stock or other equity securities, if any, that the Company desires
to sell, which can be sold without exceeding the Maximum Number of Securities; (B) second, to the extent that the Maximum Number of Securities
has not been reached under the foregoing clause (A), the Registrable Securities of Holders exercising their rights to register their Registrable
Securities pursuant to subsection 2.2.1 hereof, Pro Rata, based on the respective number of Registrable Securities that each Holder has
so requested, which can be sold without exceeding the Maximum Number of Securities; and (C) third, to the extent that the Maximum Number
of Securities has not been reached under the foregoing clauses (A) and (B), Common Stock or other equity securities, if any, for the account
of other persons or entities that the Company is obligated to register pursuant to separate written contractual arrangements with such
persons or entities, which can be sold without exceeding the Maximum Number of Securities; and

 

    9 

     

    

 

		(ii)	If the Registration is pursuant to a request by persons or entities other than the Holders of Registrable
Securities, then the Company shall include in any such Registration (A) first, Common Stock or other equity securities, if any, of such
requesting persons or entities, other than the Holders of Registrable Securities, which can be sold without exceeding the Maximum Number
of Securities; (B) second, to the extent that the Maximum Number of Securities has not been reached under the foregoing clause (A), the
Registrable Securities of Holders exercising their rights to register their Registrable Securities pursuant to subsection 2.2.1, Pro Rata
based on the respective number of Registrable Securities that each Holder has requested, which can be sold without exceeding the Maximum
Number of Securities; (C) third, to the extent that the Maximum Number of Securities has not been reached under the foregoing clauses
(A) and (B), Common Stock or other equity securities that the Company desires to sell, which can be sold without exceeding the Maximum
Number of Securities; and (D) fourth, to the extent that the Maximum Number of Securities has not been reached under the foregoing clauses
(A), (B) and (C), Common Stock or other equity securities, if any, for the account of other persons or entities that the Company is obligated
to register pursuant to separate written contractual arrangements with such persons or entities, which can be sold without exceeding the
Maximum Number of Securities.

 

2.2.3      
Piggyback Registration Withdrawal. Any Holder of Registrable Securities shall have the right to withdraw from a Piggyback
Registration for any or no reason whatsoever upon written notification to the Company and the Underwriter or Underwriters (if any) of
his, her or its intention to withdraw from such Piggyback Registration prior to the effectiveness of the Registration Statement filed
with the Commission with respect to such Piggyback Registration, or, if such Piggyback Registration is in connection with an underwritten
offering pursuant to an effective shelf registration statement, then prior to the public announcement of such offering. The Company (whether
on its own good faith determination or as the result of a request for withdrawal by persons pursuant to separate written contractual obligations)
may withdraw a Registration Statement filed with the Commission in connection with a Piggyback Registration at any time prior to the effectiveness
of such Registration Statement. Notwithstanding anything to the contrary in this Agreement, the Company shall be responsible for the Registration
Expenses incurred in connection with the Piggyback Registration prior to its withdrawal under this subsection 2.2.3.

 

2.2.4      
Right to Terminate Registration. The Company shall have the right to terminate or withdraw any registration initiated by
it under this Section 2.2 prior to the effectiveness of such registration whether or not any Holder of Registrable Securities
has elected to include securities in such registration.

 

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Section 2.3.       
Resale Shelf Registration Rights.

 

2.3.1      
Registration Statement Covering Resale of Registrable Securities. The Company shall prepare and file or cause to be prepared
and filed with the Commission, no later than fifteen (15) days following the Closing Date (the “Filing Deadline”),
a Registration Statement for an offering to be made on a continuous basis pursuant to Rule 415 of the Securities Act or any successor
thereto registering the resale from time to time by Holders of all of the Registrable Securities held by the Holders (the “Resale
Shelf Registration Statement”). The Resale Shelf Registration Statement shall be on Form S-3 (or, if Form S-3 is not available
to be used by the Company at such time, on Form S-1 or another appropriate form permitting Registration of such Registrable Securities
for resale). If the Resale Shelf Registration Statement is initially filed on Form S-1 and thereafter the Company becomes eligible to
use Form S-3 for secondary sales, the Company shall, as promptly as practicable, cause such Resale Shelf Registration Statement to be
amended, or shall file a new replacement Resale Shelf Registration Statement, such that the Resale Shelf Registration Statement is on
Form S-3. The Company shall use commercially reasonable efforts to cause the Resale Shelf Registration Statement to be declared effective
as soon as possible after filing; provided, however, that the Company’s obligations to include the Registrable
Securities held by a Holder in the Resale Shelf Registration Statement are contingent upon such Holder furnishing in writing to the Company
such information regarding the Holder, the securities of the Company held by the Holder and the intended method of disposition of the
Registrable Securities as shall be reasonably requested by the Company to effect the registration of the Registrable Securities, and the
Holder shall execute such documents in connection with such registration as the Company may reasonably request that are customary of a
selling stockholder in similar situations. Once effective, the Company shall use commercially reasonable efforts to keep the Resale Shelf
Registration Statement and Prospectus included therein continuously effective and to be supplemented and amended to the extent necessary
to ensure that such Registration Statement is available or, if not available, to ensure that another Registration Statement is available,
under the Securities Act at all times until the earliest of (i) the date on which all Registrable Securities and other securities covered
by such Registration Statement have been disposed of in accordance with the intended method(s) of distribution set forth in such Registration
Statement and (ii) the date on which all Registrable Securities and other securities covered by such Registration Statement have ceased
to be Registrable Securities. The Registration Statement filed with the Commission pursuant to this subsection 2.3.1 shall
contain a prospectus in such form as to permit any Holder to sell such Registrable Securities pursuant to Rule 415 under the Securities
Act (or any successor or similar provision adopted by the Commission then in effect) at any time beginning on the effective date for such
Registration Statement (subject to lock-up restrictions provided in Section 5.1 of this Agreement), and shall provide
that such Registrable Securities may be sold pursuant to any method or combination of methods legally available to, and requested by,
Holders.

 

2.3.2      
Notification and Distribution of Materials. The Company shall notify the Holders in writing of the effectiveness of the
Resale Shelf Registration Statement as soon as practicable, and in any event within one (1) Business Day after the Resale Shelf Registration
Statement becomes effective, and shall furnish to them, without charge, such number of copies of the Resale Shelf Registration Statement
(including any amendments, supplements and exhibits), the Prospectus contained therein (including each preliminary prospectus and all
related amendments and supplements) and any documents incorporated by reference in the Resale Shelf Registration Statement or such other
documents as the Holders may reasonably request in order to facilitate the sale of the Registrable Securities in the manner described
in the Resale Shelf Registration Statement.

 

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2.3.3      
Amendments and Supplements. Subject to the provisions of Section 2.3.1 above, the Company shall promptly
prepare and file with the Commission from time to time such amendments and supplements to the Resale Shelf Registration Statement and
Prospectus used in connection therewith as may be necessary to keep the Resale Shelf Registration Statement effective and to comply with
the provisions of the Securities Act with respect to the disposition of all the Registrable Securities. If any Resale Shelf Registration
Statement filed pursuant to Section 2.3.1 is filed on Form S-3 and thereafter the Company becomes ineligible to use Form
S-3 for secondary sales, the Company shall promptly notify the Holders of such ineligibility and use its commercially reasonable efforts
to file a shelf registration on an appropriate form as promptly as practicable to replace the shelf registration statement on Form S-3
and have such replacement Resale Shelf Registration Statement declared effective as promptly as practicable and to cause such replacement
Resale Shelf Registration Statement to remain effective, and to be supplemented and amended to the extent necessary to ensure that such
Resale Shelf Registration Statement is available or, if not available, that another Resale Shelf Registration Statement is available,
for the resale of all the Registrable Securities held by the Holders until all such Registrable Securities have ceased to be Registrable
Securities; provided, however, that at any time the Company once again becomes eligible to use Form S-3, the Company
shall cause such replacement Resale Shelf Registration Statement to be amended, or shall file a new replacement Resale Shelf Registration
Statement, such that the Resale Shelf Registration Statement is once again on Form S-3.

 

2.3.4      
SEC Cutback. Notwithstanding the registration obligations set forth in this Section 2.3, in the event the Commission
informs the Company that all of the Registrable Securities cannot, as a result of the application of Rule 415, be registered for resale
as a secondary offering on a single registration statement, the Company agrees to promptly (i) inform each of the Holders thereof and
use its commercially reasonable efforts to file amendments to the Resale Shelf Registration Statement as required by the Commission and/or
(ii) withdraw the Resale Shelf Registration Statement and file a new registration statement (a “New Registration Statement”)
on Form S-3, or if Form S-3 is not then available to the Company for such registration statement, on such other form available to register
for resale the Registrable Securities as a secondary offering; provided, however, that prior to filing such amendment
or New Registration Statement, the Company shall use its commercially reasonable efforts to advocate with the Commission for the registration
of all of the Registrable Securities in accordance with any publicly -available written or oral guidance, comments, requirements or requests
of the Commission staff (the “SEC Guidance”). Notwithstanding any other provision of this Agreement, if any SEC Guidance
sets forth a limitation on the number of Registrable Securities permitted to be registered on a particular Registration Statement as a
secondary offering (and notwithstanding that the Company used diligent efforts to advocate with the Commission for the registration of
all or a greater number of Registrable Securities), unless otherwise directed in writing by a Holder as to further limit its Registrable
Securities to be included on the Registration Statement, the number of Registrable Securities to be registered on such Registration Statement
will be reduced on a Pro Rata basis based on the total number of Registrable Securities held by the Holders, subject to a determination
by the Commission that certain Holders must be reduced first based on the number of Registrable Securities held by such Holders. In the
event the Company amends the Resale Shelf Registration Statement or files a New Registration Statement, as the case may be, under clauses
(i) or (ii) above, the Company will use its commercially reasonable efforts to file with the Commission, as promptly as allowed by Commission
or SEC Guidance provided to the Company or to registrants of securities in general, one or more registration statements on Form S-3 or
such other form available to register for resale those Registrable Securities that were not registered for resale on the Resale Shelf
Registration Statement, as amended, or the New Registration Statement.

 

2.3.5      
Underwritten Shelf Takedown. At any time and from time to time after a Resale Shelf Registration Statement has been declared
effective by the Commission, the Holders may request to sell all or any portion of the Registrable Securities in an underwritten offering
that is registered pursuant to the Resale Shelf Registration Statement (each, an “Underwritten Shelf Takedown”); provided, however,
that the Company shall only be obligated to effect an Underwritten Shelf Takedown if such offering shall include securities with a total
offering price (including piggyback securities and before deduction of underwriting discounts or commissions) reasonably expected to exceed,
in the aggregate, $15,000,000. All requests for Underwritten Shelf Takedowns shall be made by giving written notice to the Company at
least seven (7) days prior to the public announcement of such Underwritten Shelf Takedown, which shall specify the approximate number
of Registrable Securities proposed to be sold in the Underwritten Shelf Takedown and the expected price range (net of underwriting discounts
and commissions) of such Underwritten Shelf Takedown. Except in the case of a requested Underwritten Shelf Takedown in the form of a Block
Trade, following receipt of a request for an Underwritten Shelf Takedown, the Company shall promptly notify the other Holders of the request
and of their right to participate in the Underwritten Shelf Takedown, which shall specify the anticipated public announcement date. The
Company shall include in any Underwritten Shelf Takedown the securities requested to be included by any Holder (each a “Takedown
Requesting Holder”) at least 48 hours prior to the anticipated public announcement date of such Underwritten Shelf Takedown
set forth in the Company notice pursuant to written contractual piggyback registration rights of such Holder (including those set forth
herein). All such Holders proposing to distribute their Registrable Securities through an Underwritten Shelf Takedown under this subsection
2.3.5 shall enter into an underwriting agreement in customary form with the Underwriter(s) selected for such Underwritten Offering
by the majority-in-interest of the Takedown Requesting Holders initiating the Underwritten Shelf Takedown.

 

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2.3.6      
Reduction of Underwritten Shelf Takedown. If the managing Underwriter(s) in an Underwritten Shelf Takedown, in good faith,
advise(s) the Company and the Takedown Requesting Holders in writing that the dollar amount or number of Registrable Securities that the
Takedown Requesting Holders desire to sell, taken together with all other shares of the Common Stock or other equity securities that the
Company desires to sell, exceeds the Maximum Number of Securities, then the Company shall include in such Underwritten Shelf Takedown,
as follows: (i) first, the Registrable Securities of the Takedown Requesting Holders, on a Pro Rata basis, that can be sold without exceeding
the Maximum Number of Securities; (ii) second, to the extent that the Maximum Number of Securities has not been reached under the foregoing
clause (i), the Common Stock or other equity securities, if any, that the Company desires to sell, which can be sold without exceeding
the Maximum Number of Securities; and (iii) third, to the extent that the Maximum Number of Securities has not been reached under the
foregoing clause (ii) and (iii) the Common Stock or other equity securities, if any, for the account of other persons or entities that
the Company is obligated to register pursuant to separate written contractual arrangements with such persons or entities, which can be
sold without exceeding the Maximum Number of Securities.

 

2.3.7      
Block Trades. If the Company shall receive a request from a Holder or Holders of Registrable Securities with an estimated
market value of at least $15,000,000 that the Company effect the sale of all or any portion of such Registrable Securities in an Underwritten
Shelf Takedown in the form of a Block Trade, then the Company shall, as expeditiously as possible, cooperate and effect the offering in
such Block Trade of the Registrable Securities for which such requesting Holder has requested such offering, without giving any effect
to any required notice periods or delivery of notices to any other Holders.

 

Article
III 

COMPANY PROCEDURES

 

Section 3.1.       
General Procedures. If at any time the Company is required to effect the Registration of Registrable Securities, the Company
shall use its commercially reasonable efforts to effect such Registration to permit the sale of such Registrable Securities in accordance
with the intended plan of distribution thereof, and pursuant thereto the Company shall, as expeditiously as possible:

 

3.1.1      
prepare and file with the Commission as soon as practicable a Registration Statement with respect to such Registrable Securities
and use its commercially reasonable efforts to cause such Registration Statement to become effective and remain effective until all Registrable
Securities covered by such Registration Statement have been sold;

 

3.1.2      
prepare and file with the Commission such amendments and post-effective amendments to the Registration Statement, and such supplements
to the Prospectus, as may be reasonably requested by the Holders or any Underwriter of Registrable Securities or as may be required by
the rules, regulations or instructions applicable to the registration form used by the Company or by the Securities Act or rules and regulations
thereunder to keep the Registration Statement effective until all Registrable Securities covered by such Registration Statement are sold
in accordance with the intended plan of distribution set forth in such Registration Statement or supplement to the Prospectus;

 

3.1.3      
prior to filing a Registration Statement or Prospectus, or any amendment or supplement thereto, furnish without charge to the Underwriter(s),
if any, and the Holders of Registrable Securities included in such Registration, and such Holders’ legal counsel, copies of such
Registration Statement as proposed to be filed, each amendment and supplement to such Registration Statement (in each case including all
exhibits thereto and documents incorporated by reference therein), the Prospectus included in such Registration Statement (including each
preliminary Prospectus), and such other documents as the Underwriters and the Holders of Registrable Securities included in such Registration
or the legal counsel for any such Holders may request in order to facilitate the disposition of the Registrable Securities owned by such
Holders;

 

    13 

     

    

 

3.1.4      
prior to any public offering of Registrable Securities, use its commercially reasonable efforts to (i) register or qualify the
Registrable Securities covered by the Registration Statement under such securities or “Blue Sky” laws of such jurisdictions
in the United States as the Holders of Registrable Securities included in such Registration Statement (in light of their intended plan
of distribution) may request and (ii) take such action necessary to cause such Registrable Securities covered by the Registration Statement
to be registered with or approved by such other governmental authorities as may be necessary by virtue of the business and operations
of the Company and do any and all other acts and things that may be necessary or advisable to enable the Holders of Registrable Securities
included in such Registration Statement to consummate the disposition of such Registrable Securities in such jurisdictions; provided, however,
that the Company shall not be required to qualify generally to do business in any jurisdiction where it would not otherwise be required
to qualify or take any action to which it would be subject to general service of process or taxation in any such jurisdiction where it
is not then otherwise so subject;

 

3.1.5      
cause all such Registrable Securities to be listed on each securities exchange or automated quotation system on which similar securities
issued by the Company are then listed;

 

3.1.6      
provide a transfer agent and registrar for all such Registrable Securities no later than the effective date of such Registration
Statement;

 

3.1.7      
advise each seller of such Registrable Securities, promptly after it shall receive notice or obtain knowledge thereof, of the issuance
of any stop order by the Commission suspending the effectiveness of such Registration Statement or the initiation or threatening of any
proceeding for such purpose and promptly use its commercially reasonable efforts to prevent the issuance of any stop order or to obtain
its withdrawal if such stop order should be issued;

 

3.1.8      
advise each Holder of Registrable Securities covered by such Registration Statement, promptly after the Company receives notice
thereof, of the time when such registration statement has been declared effective or a supplement to any Prospectus forming a part of
such registration statement has been filed;

 

3.1.9      
at least five (5) days prior to the filing of any Registration Statement or Prospectus or any amendment or supplement to such Registration
Statement or Prospectus, furnish a draft copy thereof to each seller of such Registrable Securities or its counsel;

 

3.1.10   
notify the Holders at any time when a Prospectus relating to such Registration Statement is required to be delivered under the
Securities Act, of the happening of any event as a result of which the Prospectus included in such Registration Statement, as then in
effect, includes a Misstatement, and then to correct such Misstatement as set forth in Section 3.4 hereof;

 

3.1.11   
permit a representative of the Holders, the Underwriter(s), if any, and any attorney or accountant retained by such Holders or
Underwriter(s) to participate, at each such person’s own expense (except as otherwise set forth herein), in the preparation of the
Registration Statement, and cause the Company’s officers, directors and employees to supply all information reasonably requested
by any such representative, Underwriter(s), attorney or accountant in connection with the Registration; provided, however,
that such representatives or Underwriter(s) enter into a confidentiality agreement, in form and substance reasonably satisfactory to the
Company, prior to the release or disclosure of any such information;

 

    14 

     

    

 

3.1.12   
obtain a “cold comfort” letter from the Company’s independent registered public accountants in the event of an
Underwritten Registration, in customary form and covering such matters of the type customarily covered by “cold comfort” letters
as the managing Underwriter(s) may reasonably request, and reasonably satisfactory to a majority-in-interest of the participating Holders
and such managing Underwriter;

 

3.1.13   
on the date the Registrable Securities are delivered for sale pursuant to such Registration, if requested by the Underwriter(s),
if any, obtain an opinion and negative assurance letter, dated such date, of counsel representing the Company for the purposes of such
Registration addressed to the Underwriter(s) covering such legal matters with respect to the Registration in respect of which such opinion
and negative assurance letter are being given as are customarily included in such opinions and negative assurance letters;

 

3.1.14   
in the event of any Underwritten Offering, enter into and perform its obligations under an underwriting agreement, in usual and
customary form, with the managing Underwriter(s) of such offering;

 

3.1.15   
make available to its security holders, as soon as reasonably practicable, an earnings statement covering the period of at least
twelve (12) months beginning with the first day of the Company’s first full calendar quarter after the effective date of the Registration
Statement which satisfies the provisions of Section 11(a) of the Securities Act and Rule 158 thereunder (or any successor
rule promulgated thereafter by the Commission);

 

3.1.16   
if a Registration, including an Underwritten Offering, involves the Registration of Registrable Securities involving gross proceeds
in excess of $35,000,000, use its commercially reasonable efforts to make available senior executives of the Company to participate in
customary “road show” presentations that may be reasonably requested by the Underwriter(s) in any Underwritten Offering; and

 

3.1.17   
otherwise, in good faith, cooperate reasonably with, and take such customary actions as may reasonably be requested by the Holders,
in connection with such Registration.

 

Section 3.2.       
Registration Expenses. All Registration Expenses shall be borne by the Company. It is acknowledged by the Holders that the
Holders shall bear all incremental selling expenses relating to the sale of Registrable Securities, such as Underwriters’ commissions
and discounts, brokerage fees, Underwriter marketing costs.

 

Section 3.3.       
Requirements for Participation in Underwritten Offerings. No person may participate in any Underwritten Offering for equity
securities of the Company pursuant to a Registration initiated by the Company hereunder unless such person (i) agrees to sell such person’s
securities on the basis provided in any underwriting arrangements approved by the Company and (ii) completes and executes all customary
questionnaires, powers of attorney, indemnities, lock-up agreements, underwriting agreements and other customary documents as may be reasonably
required under the terms of such underwriting arrangements.

 

    15 

     

    

 

Section 3.4.       
Suspension of Sales; Adverse Disclosure. Upon receipt of written notice from the Company that a Registration Statement or Prospectus
contains a Misstatement, each of the Holders shall forthwith discontinue disposition of Registrable Securities until he, she or it has
received copies of a supplemented or amended Prospectus correcting the Misstatement or until he, she, or it is advised in writing by the
Company that the use of the Prospectus may be resumed, provided that the Company hereby covenants to prepare and file any required supplement
or amendment correcting any Misstatement promptly after the time of such notice and, if necessary, to request the immediate effectiveness
thereof. If the filing, initial effectiveness or continued use of a Registration Statement or Prospectus included in any Registration
Statement at any time (a) would require the Company to make an Adverse Disclosure, (b) would require the inclusion in such Registration
Statement of financial statements that are unavailable to the Company for reasons beyond the Company’s control, or (c) in the good
faith judgment of the Board, would be materially detrimental to the Company, the Company shall have the right to defer the filing, initial
effectiveness or continued use of any Registration Statement pursuant to (a), (b) or (c) for a period of not more than ninety (90) consecutive
days or more than one hundred and twenty (120) total calendar days in any 12-month period. In the event the Company exercises its rights
under the preceding sentence, the Holders agree to suspend, immediately upon their receipt of the notice referred to above, their use
of the Prospectus relating to any Registration in connection with any sale or offer to sell Registrable Securities.

 

Section 3.5.       
Reporting Obligations. As long as any Holder shall own Registrable Securities, the Company, at all times while it shall be
a reporting company under the Exchange Act, covenants to file timely (or obtain extensions in respect thereof and file within the applicable
grace period) all reports required to be filed by the Company after the date hereof pursuant to Sections 13(a) or 15(d) of the Exchange
Act and to promptly furnish the Holders with true and complete copies of all such filings. The Company further covenants that it shall
take such further action as any Holder may reasonably request, all to the extent required from time to time to enable such Holder to sell
shares of Common Stock held by such Holder without registration under the Securities Act within the limitation of the exemptions provided
by Rule 144 promulgated under the Securities Act (or any successor rule promulgated thereafter by the Commission), including providing
any customary legal opinions as reasonably requested. Upon the request of any Holder, the Company shall deliver to such Holder a written
certification of a duly authorized officer as to whether it has complied with such requirements.

 

Section 3.6.       
Limitations on Registration Rights. Other than the registration rights granted to the purchasers under the Subscription Agreements
to be entered into on about the date hereof with certain investors relating to the private placement of shares of Common Stock as provided
for in the Business Combination Agreement, the Company represents and warrants that no person or entity, other than a Holder of Registrable
Securities, has any right to require the Company to register any securities of the Company for sale or to include such securities of the
Company in any Registration Statement filed by the Company for the sale of securities for its own account or for the account of any other
person or entity. The Company hereby agrees and covenants that it will not grant rights to register any Common Stock (or securities convertible
into or exchangeable for Common Stock) pursuant to the Securities Act that are more favorable, pari passu or senior to those granted to
the Holders hereunder without (a) the prior written consent of (i) Perceptive Holders holding at least a majority in interest of the then-outstanding
number of Registrable Securities held by all Perceptive Holders in their capacity as Perceptive Holders (provided the Perceptive Holders
or their Permitted Transferees hold Registrable Securities at such time) and (ii) Amber GT (provided Amber GT or its Permitted Transferees
hold Registrable Securities at such time); or (b) granting economically and legally equivalent rights to the Holders hereunder such that
the Holders shall receive the benefit of such more favorable or senior terms and/or conditions. Further, the Company represents and warrants
that this Agreement supersedes any other registration rights agreement or agreement with similar terms and conditions and in the event
of any conflict between any such agreement or agreements and this Agreement, the terms of this Agreement shall prevail.

 

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Article
IV 

INDEMNIFICATION AND CONTRIBUTION

 

Section 4.1.       
Indemnification.

 

4.1.1      
The Company agrees to indemnify, to the extent permitted by law, each Holder of Registrable Securities, its officers and directors
and agents and each person who controls such Holder (within the meaning of the Securities Act) against all losses, claims, damages, liabilities
and expenses (including attorneys’ fees) caused by any untrue or alleged untrue statement of material fact contained in any Registration
Statement, Prospectus or preliminary Prospectus or any amendment thereof or supplement thereto or any omission or alleged omission of
a material fact required to be stated therein or necessary to make the statements therein not misleading, except insofar as the same are
caused by or contained in any information furnished in writing to the Company by such Holder expressly for use therein. The Company shall
indemnify the Underwriter(s), their officers and directors and each person who controls (within the meaning of the Securities Act) such
Underwriter(s) to the same extent as provided in the foregoing with respect to the indemnification of the Holder.

 

4.1.2      
In connection with any Registration Statement in which a Holder of Registrable Securities is participating, such Holder shall furnish
to the Company in writing such information and affidavits as the Company reasonably requests for use in connection with any such Registration
Statement or Prospectus and, to the extent permitted by law, shall indemnify the Company, its directors and officers and agents and each
person who controls (within the meaning of the Securities Act) the Company against any losses, claims, damages, liabilities and expenses
(including without limitation reasonable attorneys’ fees) resulting from any untrue statement of material fact contained in the
Registration Statement, Prospectus or preliminary Prospectus or any amendment thereof or supplement thereto or any omission of a material
fact required to be stated therein or necessary to make the statements therein not misleading, but only to the extent that such untrue
statement or omission is contained in any information or affidavit so furnished in writing by such Holder expressly for use therein; provided, however,
that the obligation to indemnify shall be several, not joint and several, among such Holders of Registrable Securities, and the liability
of each such Holder of Registrable Securities shall be in proportion to and limited to the net proceeds actually received by such Holder
from the sale of Registrable Securities pursuant to such Registration Statement. The Holders of Registrable Securities shall indemnify
the Underwriter(s), their officers, directors and each person who controls (within the meaning of the Securities Act) such Underwriter(s)
to the same extent as provided in the foregoing with respect to indemnification of the Company.

 

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4.1.3      
Any person entitled to indemnification herein shall (i) give prompt written notice to the indemnifying party of any claim with
respect to which it seeks indemnification (provided, however, that the failure to give prompt notice shall not impair
any person’s right to indemnification hereunder to the extent such failure has not materially prejudiced the indemnifying party)
and (ii) unless in such indemnified party’s reasonable judgment a conflict of interest between such indemnified and indemnifying
parties may exist with respect to such claim, permit such indemnifying party to assume the defense of such claim with counsel reasonably
satisfactory to the indemnified party. If such defense is assumed, the indemnifying party shall not be subject to any liability for any
settlement made by the indemnified party without its consent (but such consent shall not be unreasonably withheld, conditioned or delayed).
An indemnifying party who is not entitled to, or elects not to, assume the defense of a claim shall not be obligated to pay the fees and
expenses of more than one counsel for all parties indemnified by such indemnifying party with respect to such claim, unless in the reasonable
judgment of any indemnified party a conflict of interest may exist between such indemnified party and any other of such indemnified parties
with respect to such claim. No indemnifying party shall, without the consent of the indemnified party, consent to the entry of any judgment
or enter into any settlement which cannot be settled in all respects by the payment of money (and such money is so paid by the indemnifying
party pursuant to the terms of such settlement) or which settlement does not include as an unconditional term thereof the giving by the
claimant or plaintiff to such indemnified party of a release from all liability in respect to such claim or litigation.

 

4.1.4      
The indemnification provided for under this Agreement shall remain in full force and effect regardless of any investigation made
by or on behalf of the indemnified party or any officer, director or controlling person of such indemnified party and shall survive the
transfer of securities. The Company and each Holder of Registrable Securities participating in an offering also agrees to make such provisions
as are reasonably requested by any indemnified party for contribution (pursuant to subsection 4.1.5) to such party in the
event the Company’s or such Holder’s indemnification is unavailable for any reason.

 

4.1.5      
If the indemnification provided under Section 4.1 hereof from the indemnifying party is unavailable or insufficient
to hold harmless an indemnified party in respect of any losses, claims, damages, liabilities and expenses referred to herein, then the
indemnifying party, in lieu of indemnifying the indemnified party, shall contribute to the amount paid or payable by the indemnified party
as a result of such losses, claims, damages, liabilities and expenses in such proportion as is appropriate to reflect the relative fault
of the indemnifying party and the indemnified party, as well as any other relevant equitable considerations. The relative fault of the
indemnifying party and indemnified party shall be determined by reference to, among other things, whether any action in question, including
any untrue or alleged untrue statement of a material fact or omission or alleged omission to state a material fact, was made by, or relates
to information supplied by, such indemnifying party or indemnified party, and the indemnifying party’s and indemnified party’s
relative intent, knowledge, access to information and opportunity to correct or prevent such action; provided, however,
that the liability of any Holder under this subsection 4.1.5 shall be limited to the amount of the net proceeds actually
received by such Holder in such offering giving rise to such liability. The amount paid or payable by a party as a result of the losses
or other liabilities referred to above shall be deemed to include, subject to the limitations set forth in subsections 4.1.1, 4.1.2 and 4.1.3 above,
any legal or other fees, charges or expenses reasonably incurred by such party in connection with any investigation or proceeding. The
parties hereto agree that it would not be just and equitable if contribution pursuant to this subsection 4.1.5 were determined
by pro rata allocation or by any other method of allocation, which does not take account of the equitable considerations referred to in
this subsection 4.1.5. No person guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of
the Securities Act) shall be entitled to contribution pursuant to this subsection 4.1.5 from any person who was not guilty
of such fraudulent misrepresentation.

 

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4.1.6      
Notwithstanding the foregoing, to the extent that the provisions on indemnification and contribution contained in any underwriting
agreement entered into in connection with an underwritten public offering are in conflict with the foregoing provisions, the provisions
in the underwriting agreement shall control.

 

Article
V 

LOCK-UP

 

Section 5.1.        Lock-Up.
Except as permitted by Section 5.2, each Holder shall not Transfer any shares of Common Stock (including, without limitation,
the PIPE Shares, any shares of Common Stock issued pursuant to the Business Combination Agreement, and any other shares of Common Stock),
beneficially owned or owned of record by such Holder until the date that is 365 days from the Closing Date (the “Lock-up Period”).

 

Section 5.2.        Exceptions. The provisions of Section 5.1 shall not apply (i) to the Original Holders or the Perceptive Holders
in connection with any of the following, and (ii) to Amber GT in connection with subsections 5.2.6(i), 5.2.10, 5.2.11
or 5.2.12:

 

5.2.1      transactions
relating to shares of Common Stock acquired in open market transactions;

 

5.2.2      Transfers
of shares of Common Stock or any security convertible into or exercisable or exchangeable for Common Stock as a bona fide gift or charitable
contribution;

 

5.2.3      Transfers of shares of Common Stock to a trust, or other entity formed for estate planning purposes for the primary benefit of
the spouse, domestic partner, parent, sibling, child or grandchild of the undersigned or any other person with whom the undersigned has
a relationship by blood, marriage or adoption not more remote than first cousin;

 

5.2.4      Transfers by will or intestate succession upon the death of the undersigned;

 

5.2.5      the
Transfer of shares of Common Stock pursuant to a qualified domestic order, court order or in connection with a divorce settlement;

 

     20

     

    

 

5.2.6      if the Holder is a corporation, partnership (whether general, limited or otherwise), limited liability company, trust or other
business entity, (i) Transfers to another corporation, partnership, limited liability company, trust or other business entity that controls,
is controlled by or is under common control or management with the Holder, or (ii) distributions of shares of Common Stock to partners,
limited liability company members or stockholders of the Holder, including, for the avoidance of doubt, where the Holder is a partnership,
to its general partner or a successor partnership or fund, or any other funds managed by such partnership;

 

5.2.7      if
the Holder is a trust, Transfers to a trustor or beneficiary of the trust or to the estate of a beneficiary of such trust;

 

5.2.8      Transfers
to the Company’s officers, directors or their affiliates;

 

5.2.9      Transfers to a nominee or custodian of a person or entity to whom a disposition or transfer would be permissible under Sections
5.2.2 through 5.2.8;

 

5.2.10    pledges
of shares of Common Stock or other Registrable Securities as security or collateral in connection with any borrowing or the incurrence
of any indebtedness by any Holder;

 

5.2.11    Transfers
pursuant to a bona fide third-party tender offer, merger, stock sale, recapitalization, consolidation or other transaction involving
a Change in Control of the Company; provided, however, that in the event that such tender offer, merger, recapitalization,
consolidation or other such transaction is not completed, the Common Stock subject to this Agreement shall remain subject to this Agreement;

 

5.2.12    the
establishment of a trading plan pursuant to Rule 10b5-1 promulgated under the Exchange Act; provided, however,
that such plan does not provide for the Transfer of Common Stock or any securities convertible into or exercisable or exchangeable for
Common Stock during the Lock-Up Period;

 

provided, however, that in
the case of any Transfer pursuant to Sections 5.2.2 through 5.2.10, each donee, distribute, pledgee or other
transferee shall agree in writing, in form and substance reasonably satisfactory to the Company, to be bound by the provisions of this
Agreement, provided further, however, that the foregoing requirement shall not apply with respect to pledges made by Amber
GT or any of its Permitted Transferees pursuant to requirements under agreements governing borrowings or the incurrence of any indebtedness
by Parent and its subsidiaries.

 

Section 5.3.        Termination
of Existing Lock-Up. The lock-up provisions in this ARTICLE V shall supersede the lock-up provisions contained in Section
5 of the Sponsor Letter Agreement and Section 1.C.(i) of the Private Placement Shares Purchase Agreement, which provisions shall be of
no further force or effect as of the Closing Date.

 

Section 5.4.        Release
of Lock-Up Restrictions. Notwithstanding the other provisions set forth herein, the Board may, in its sole discretion, determine
to waive, amend, or repeal the restrictions set forth in Section 5.1 above, whether in whole or in part; provided,
that any such waiver, amendment or repeal shall (i) not make such restrictions more restrictive or apply for a longer period of time,
(ii) apply to each Holder equally, and (iii) require the unanimous approval of the directors present at any duly called meeting at which
a quorum is present. Notwithstanding anything to the contrary herein or in the LLC Agreement, any amendment, modification or waiver of,
or consent, approval or agreement under, the LLC Agreement (whether by the Board of Managers (as defined in the LLC Agreement), the Company
or otherwise) or any agreement with a Non-Corporation Member (as defined in the LLC Agreement) that (A) shortens, or has the effect of
shortening, the “Lock-up Period” (as defined in the LLC Agreement (as in effect following the consummation of the transactions
contemplated by the Business Combination Agreement)) (the “LLC Lock-Up Period”) with respect to a Non-Corporation
Member or (B) prior to the end of the LLC Lock-up Period, that allows, or has the effect of allowing, a Non-Corporation Member to transfer
its Common Units to any Person other than to a Permitted Transferee (as defined in the LLC Agreement (as in effect following the consummation
of the transactions contemplated by the Business Combination Agreement), and on the terms and subject to the conditions set forth therein)
shall, in each case, automatically have the effect of shortening the Lock-up Period hereunder for an equivalent amount of time, with
respect to clause (A), or immediately releasing all Holders from the transfer restrictions set forth in Section 5.1 hereunder,
with respect to clause (B).

 

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Article
VI 

TERMINATION

 

Section 6.1.       
Termination. This Agreement shall terminate upon the earliest to occur of: (i) the date on which neither the Holders nor any
of their Permitted Transferees hold any Registrable Securities and (ii) a Liquidation Event. The provisions of Section 3.5
and Article IV shall survive any termination.

 

Section 6.2.       
Effect of Business Combination Termination. In the event of a termination of this Agreement as a result of the termination
of the Business Combination Agreement, this Agreement shall become void; this Agreement shall only become effective upon the consummation
of the transactions set forth in the Business Combination Agreement, and prior to such date this Agreement shall be of no force and effect.

 

Article
VII 

GENERAL PROVISIONS

 

Section 7.1.       
Notices. All notices, requests, claims, demands and other communications hereunder shall be in writing and shall be given (and
shall be deemed to have been duly given upon receipt) by delivery in person, by e-mail or by registered or certified mail (postage prepaid,
return receipt requested) to the respective parties at the following addresses or e-mail addresses (or at such other address or email
address for a party as shall be specified in a notice given in accordance with this Section 7.1):

 

If to the Company, to it at:

 

3675 Market Street

Philadelphia, PA 19104

Attention: John F. Crowley
 

with a copy (which shall not constitute notice)
to:

 

Kirkland & Ellis LLP

601 Lexington Avenue

New York, NY 10022

Attn:      Jonathan L. Davis, P.C.

Ryan Brissette

Email:    jonathan.davis@kirkland.com

ryan.brissette@kirkland.com

 

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If to a Holder, to the address
or email address set forth for Holder on the signature page hereof.

 

Section 7.2.       
Severability. If any term or other provision of this Agreement is invalid, illegal or incapable of being enforced by any rule
of law or public policy, all other conditions and provisions of this Agreement shall nevertheless remain in full force and effect so long
as the economic or legal substance of the transactions contemplated hereby is not affected in any manner materially adverse to any party.
Upon such determination that any term or other provision is invalid, illegal or incapable of being enforced, the parties hereto shall
negotiate in good faith to modify this Agreement so as to effect the original intent of the parties as closely as possible in a mutually
acceptable manner in order that the transactions contemplated hereby be consummated as originally contemplated to the fullest extent possible.

 

Section 7.3.       
Entire Agreement; Assignment.

 

7.3.1      
This Agreement constitutes the entire agreement among the parties with respect to the subject matter hereof and supersedes all
prior agreements and undertakings, both written and oral, among the parties, or any of them, with respect to the subject matter hereof.

 

7.3.2      
 This Agreement shall not be assigned (whether pursuant to a merger, by operation of law or otherwise), by any Holder without the
prior express written consent of the Company, except that (i) any Holder may, without consent, assign such Holder’s rights under
this Agreement to any transferee of Common Stock permitted under Section 5.2 and (ii) after the expiration of the Lock-Up
Period, any Holder may, without consent, assign its rights, in whole and not in part, to any transferee of its Registrable Securities
provided that such transferee continues to hold Registrable Securities following such Transfer (any such transferees in each of clause
(i) and (ii), a “Permitted Transferee”). This Agreement and the rights, duties and obligations of the Company hereunder
may not be assigned or delegated by the Company in whole or in part. Any assignment made other than as provided in this Section 7.3 shall
be null and void.

 

Section 7.4.       
Parties in Interest. This Agreement shall be binding upon and inure solely to the benefit of each party hereto (and its respective
successors and permitted assigns), and nothing in this Agreement, express or implied, is intended to or shall confer upon any other person
any right, benefit or remedy of any nature whatsoever under or by reason of this Agreement.

 

     23

     

    

 

Section 7.5.       
Governing Law. This Agreement shall be governed by, and construed in accordance with, the laws of the State of Delaware applicable
to contracts executed in and to be performed in that State. All legal actions and proceedings arising out of or relating to this Agreement
shall be heard and determined exclusively in any Delaware Chancery Court; provided, however, that if jurisdiction
is not then available in the Delaware Chancery Court, then any such legal action may be brought in any federal court located in the State
of Delaware or any other Delaware state court. The parties hereto hereby (a) irrevocably submit to the exclusive jurisdiction of the aforesaid
courts for themselves and with respect to their respective properties for the purpose of any action arising out of or relating to this
Agreement brought by any party hereto, and (b) agree not to commence any action relating thereto except in the courts described above
in Delaware, other than actions in any court of competent jurisdiction to enforce any judgment, decree or award rendered by any such court
in Delaware as described herein. Each of the parties further agrees that notice as provided herein shall constitute sufficient service
of process and the parties further waive any argument that such service is insufficient. Each of the parties hereby irrevocably and unconditionally
waives, and agrees not to assert, by way of motion or as a defense, counterclaim or otherwise, in any action arising out of or relating
to this Agreement or the transactions contemplated hereby, (x) any claim that it is not personally subject to the jurisdiction of the
courts in Delaware as described herein for any reason, (y) that it or its property is exempt or immune from jurisdiction of any such court
or from any legal process commenced in such courts (whether through service of notice, attachment prior to judgment, attachment in aid
of execution of judgment, execution of judgment or otherwise) and (z) that (i) the action in any such court is brought in an inconvenient
forum, (ii) the venue of such action is improper or (iii) this Agreement, or the subject matter hereof, may not be enforced in or by such
courts.

 

Section 7.6.       
Waiver of Jury Trial. EACH OF THE PARTIES HERETO HEREBY WAIVES TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW ANY RIGHT
IT MAY HAVE TO A TRIAL BY JURY WITH RESPECT TO ANY LITIGATION DIRECTLY OR INDIRECTLY ARISING OUT OF, UNDER OR IN CONNECTION WITH THIS
AGREEMENT. EACH OF THE PARTIES HERETO (I) CERTIFIES THAT NO REPRESENTATIVE, AGENT OR ATTORNEY OF ANY OTHER PARTY HAS REPRESENTED, EXPRESSLY
OR OTHERWISE, THAT SUCH OTHER PARTY WOULD NOT, IN THE EVENT OF LITIGATION, SEEK TO ENFORCE THAT FOREGOING WAIVER AND (II) ACKNOWLEDGES
THAT IT AND THE OTHER PARTIES HERETO HAVE BEEN INDUCED TO ENTER INTO THIS AGREEMENT AND THE TRANSACTIONS CONTEMPLATED HEREBY, AS APPLICABLE,
BY, AMONG OTHER THINGS, THE MUTUAL WAIVERS AND CERTIFICATIONS IN THIS SECTION 7.6.

 

Section 7.7.       
Headings; Interpretation. The descriptive headings contained in this Agreement are included for convenience of reference only
and shall not affect in any way the meaning or interpretation of this Agreement. The parties have participated jointly in the negotiation
and drafting of this Agreement. If any ambiguity or question of intent arises, this Agreement will be construed as if drafted jointly
by the parties and no presumption or burden of proof will arise favoring or disfavoring any party because of the authorship of any provision
of this Agreement. Unless the context of this Agreement clearly requires otherwise, use of the masculine gender shall include the feminine
and neutral genders and vice versa, and the definitions of terms contained in this Agreement are applicable to the singular as well as
the plural forms of such terms. The words “includes” or “including” shall mean “including without limitation.”
The words “hereof,” “hereby,” “herein,” “hereunder” and similar terms in this Agreement
shall refer to this Agreement as a whole and not any particular section or article in which such words appear, the word “extent”
in the phrase “to the extent” shall mean the degree to which a subject or other thing extends and such phrase shall not mean
simply “if.” Any reference to a law shall include any rules and regulations promulgated thereunder, and shall mean such law
as from time to time amended, modified or supplemented. References herein to any contract (including this Agreement) mean such contract
as amended, supplemented or modified from time to time in accordance with the terms thereof.

 

     24

     

    

 

Section 7.8.       
Counterparts. This Agreement may be executed and delivered (including by facsimile or portable document format (pdf) transmission)
in counterparts, and by the different parties hereto in separate counterparts, each of which when executed shall be deemed to be an original
but all of which taken together shall constitute one and the same agreement.

 

Section 7.9.       
Specific Performance. The parties hereto agree that irreparable damage would occur in the event any provision of this Agreement
was not performed in accordance with the terms hereof and that the parties shall be entitled to specific performance of the terms hereof,
in addition to any other remedy at law or in equity. Each of the parties hereby further waives (a) any defense in any action for specific
performance that a remedy at law would be adequate and (b) any requirement under any law to post security or a bond as a prerequisite
to obtaining equitable relief.

 

Section 7.10.    
Amendment. This Agreement may not be amended except by an instrument in writing signed by (i) the Company, (ii) Perceptive
Holders holding at least a majority in interest of the then-outstanding number of Registrable Securities held by all Perceptive Holders
in their capacity as Perceptive Holders (provided the Perceptive Holders or their Permitted Transferees hold Registrable Securities at
the time of such amendment), and (iii) Amber GT (provided Amber GT or its Permitted Transferees hold Registrable Securities at the time
of such amendment); provided, however, that notwithstanding the foregoing, any amendment hereto or waiver hereof that adversely
affects one Holder, solely in its capacity as a holder of Registrable Securities, in a manner that is materially different from the other
Holders (in such capacity) shall require the consent of the Holder so affected.

 

Section 7.11.   
Waiver. At any time, (i) the Company may (a) extend the time for the performance of any obligation or other act of any Holder,
(b) waive any inaccuracy in the representations and warranties of any Holder contained herein or in any document delivered by such Holder
pursuant hereto and (c) waive compliance with any agreement of such Holder or any condition to its own obligations contained herein. At
any time, (i) the Holders may (a) extend the time for the performance of any obligation or other act of the Company, (b) waive any inaccuracy
in the representations and warranties of the Company contained herein or in any document delivered by the Company pursuant hereto and
(c) waive compliance with any agreement of the Company or any condition to their own obligations contained herein. Any such extension
or waiver shall be valid if set forth in an instrument in writing signed by the party or parties to be bound thereby.

 

     25

     

    

 

Section 7.12.   
Further Assurances. At the request of the Company, in the case of any Holder, or at the request of any Holder, in the case
of the Company, and without further consideration, each party shall execute and deliver or cause to be executed and delivered such additional
documents and instruments and take such further action as may be reasonably necessary to consummate the transactions contemplated by this
Agreement.

 

Section 7.13.   
Prior Agreement Superseded. Pursuant to Section 5.6 of the Prior Agreement, the undersigned parties who are parties to such
Prior Agreement hereby terminate the Prior Agreement upon the consummation of the transactions set forth in the Business Combination Agreement,
with the intent and effect that the Prior Agreement shall hereby be replaced and superseded in its entirety by this Agreement.

 

Section 7.14.   
No Strict Construction. The language used in this Agreement shall be deemed to be the language chosen by the parties to express
their mutual intent and no rule of strict construction shall be applied against any party.

 

(Next Page is Signature
Page)

 

     26

     

    

 

IN WITNESS WHEREOF, each of
the parties has executed this Agreement as of the date first written above.

 

	 	COMPANY: ARYA SCIENCES ACQUISITION CORP IV
	 	 
	 	By:	/s/ Michael Altman
	 	Name: Michael Altman
	 	Title: Authorized Signatory

 

[Signature Page to Investor
Rights Agreement]

 

     

     

    

 

IN WITNESS WHEREOF, each of
the undersigned has executed this Agreement as of the date first written above.

 

	 	HOLDER:
	 	 
	 	Name: ARYA Sciences Holdings IV
	 	 
	 	By:	 /s/ Michael Altman
	 	Name: Michael Altman
	 	Title: Chief Financial Officer
	 	 
	 	Address for Notice:
	 	 
	 	51 Astor Pl 10th floor, New York, NY

 

	 	 
	 	Telephone No.:	 
	 	 
	 	Facsimile No.:	 
	 	 
	 	Email:	 

 

     

     

    

 

IN WITNESS WHEREOF, each of
the undersigned has executed this Agreement as of the date first written above.

 

	 	HOLDER:
	 	 
	 	Name: Perceptive Life Sciences Master Fund Ltd
	 	 
	 	By: 	 	 
	 	Name: 
	 	Title:
	 	 
	 	Address for Notice:
	 	 
	 	51 Astor Pl 10th floor, New York, NY 10003
	 	 
	 	Telephone No.:	 
	 	 
	 	Facsimile No.:	 
	 	 
	 	Email:  	 	 

 

[Signature Page to Investor
Rights Agreement]

 

     

     

    

 

IN WITNESS WHEREOF, each of
the undersigned has executed this Agreement as of the date first written above.

 

	 	HOLDER:
	 	 
	 	Name: Amicus GT Holdings, LLC
	 	 
	 	By: 	  /s/ Bradley L. Campbell  
	 	Name:  Bradley L. Campbell
	 	Title: President 
	 	 
	 	Address for Notice:
	 	 
	 	3675 Market Street, Philadelphia, PA 19104

 

	 	Telephone No.:	   
	 	 
	 	Facsimile No.:	 
	 	 
	 	Email:  	        

 

[Signature Page to Investor
Rights Agreement]

 

     

     

    

 

IN WITNESS WHEREOF, each of
the undersigned has executed this Agreement as of the date first written above.

 

	 	HOLDER:
	 	 
	 	Name: Todd Wider
	 	 
	 	By: 	/s/ Todd Wider
	 	 	Todd Wider
	 	 
	 	Address for Notice:
	 	 
	 	Telephone No.:	 
	 	 
	 	Facsimile No.:	 
	 	 
	 	Email:  	 	 

 

[Signature Page to Investor
Rights Agreement]

 

     

     

    

 

IN WITNESS WHEREOF, each of
the undersigned has executed this Agreement as of the date first written above.

 

	 	HOLDER:
	 	 
	 	Name: Michael Henderson
	 	 
	 	By: 	/s/ Michael Henderson     
	 	 	Michael Henderson
	 	 
	 	Address for Notice:
	 	 
	 	Telephone No.:	 
	 	 
	 	Facsimile No.:	 
	 	 
	 	Email:  	 	 

 

[Signature Page to Investor
Rights Agreement]

 

     

     

    

 

IN WITNESS WHEREOF, each of
the undersigned has executed this Agreement as of the date first written above.

 

	 	HOLDER:
	 	 
	 	Name: Leslie Trigg
	 	 
	 	By: 	/s/ Leslie Trigg
	 	 	Leslie Trigg
	 	 
	 	Address for Notice:
	 	 
	 	Telephone No.:	 
	 	 
	 	Facsimile No.:	 
	 	 
	 	Email:  	 	 

 

[Signature Page to Investor
Rights Agreement]

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