Document:

exv10w1

Exhibit 10.1

 

SANTARUS, INC.

AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT

 

 

 

     This AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT (this “Agreement”) is entered into as of
July 11, 2008, by and between COMERICA BANK (“Bank”) and SANTARUS, INC. (“Borrower”).

RECITALS

     Bank and Borrower are parties to that certain Loan and Security Agreement, dated as of July
28, 2006, as amended from time to time (the “Original Agreement”). Borrower and Bank wish to amend
and restate the terms of the Original Agreement. This Agreement sets forth the terms on which Bank
will advance credit to Borrower, and Borrower will repay the amounts owing to Bank.

AGREEMENT

     The parties agree as follows:

     1. DEFINITIONS AND CONSTRUCTION.

          1.1 Definitions. As used in this Agreement, the following terms shall have the
following definitions:

               “Accounts” means all presently existing and hereafter arising accounts, contract rights,
payment intangibles, and all other forms of obligations owing to Borrower arising out of the sale
or lease of goods (including, without limitation, the licensing of software and other technology)
or the rendering of services by Borrower, whether or not earned by performance, and any and all
credit insurance, guaranties, and other security therefor, as well as all merchandise returned to
or reclaimed by Borrower and Borrower’s Books relating to any of the foregoing.

               “Advance” or “Advances” means a cash advance or cash advances under the Revolving Line.

               “Affiliate” means, with respect to any Person, any Person that owns or controls directly or
indirectly such Person, any Person that controls or is controlled by or is under common control
with such Person, and each of such Person’s senior executive officers, directors, and its general
partners, if any.

               “Bank Expenses” means (subject to reasonable documentation thereof) all out-of-pocket:
reasonable costs or expenses (including reasonable attorneys’ fees and expenses) incurred in
connection with the preparation, negotiation, administration, and enforcement of the Loan
Documents; reasonable Collateral audit fees; and Bank’s reasonable attorneys’ fees and expenses
incurred in amending, enforcing or defending the Loan Documents (including fees and expenses of
appeal), incurred by or for the benefit of Bank before, during and after an Insolvency Proceeding,
whether or not suit is brought.

               “Borrower State” means Delaware, the state under whose laws Borrower is organized.

               “Borrower’s Books” means all of Borrower’s books and records including: ledgers; records
concerning Borrower’s assets or liabilities, the Collateral, business operations or financial
condition; and all computer programs, or tape files, and the equipment, containing such
information.

               “Borrowing Base” means an amount equal to eighty percent (80%) of Eligible Accounts, as
reasonably determined by Bank with reference to the most recent Borrowing Base Certificate
delivered by Borrower.

               “Business Day” means any day that is not a Saturday, Sunday, or other day on which banks in
the State of California are authorized or required to close.

               “Cash” means unrestricted cash, cash equivalents and marketable securities.

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               “Cash Burn” means net loss (determined in accordance with GAAP), plus depreciation and
amortization, minus any decrease in deferred revenue, plus any increase in deferred revenue, plus
stock-based compensation expensed in accordance in GAAP, during the three (3) month period ending
on the measurement date, divided by three (3).

               “Change in Control” shall mean a transaction in which any “person” or “group” (within the
meaning of Section 13(d) and 14(d)(2) of the Securities Exchange Act of 1934) becomes the
“beneficial owner” (as defined in Rule 13d-3 under the Securities Exchange Act of 1934), directly
or indirectly, of a sufficient number of shares of all classes of stock then outstanding of
Borrower ordinarily entitled to vote in the election of directors, empowering such “person” or
“group” to elect a majority of the Board of Directors of Borrower, who did not have such power
before such transaction.

               “Chief Executive Office State” means California, where Borrower’s chief executive office is
located.

               “Closing Date” means the date of this Agreement.

               “Code” means the California Uniform Commercial Code, as amended or supplemented from time to
time.

               “Collateral” means the property described on Exhibit A attached hereto and all Negotiable
Collateral to the extent not described on Exhibit A, except to the extent any such property (i) is
nonassignable by its terms without the consent of the licensor thereof or another party (but only
to the extent such prohibition on transfer is enforceable under applicable law, including, without
limitation, Sections 9406 and 9408 of the Code), or (ii) the granting of a security interest
therein is contrary to applicable law, provided that upon the cessation of any such restriction or
prohibition, such property shall automatically become part of the Collateral; provided that in no
case shall the definition of “Collateral” exclude any Accounts, proceeds of the disposition of any
property, or general intangibles consisting of rights to payment.

               “Collateral State” means: the state or states in the United States where the Collateral is
located (other than: personal property used to support field services and marketing operations,
having an aggregate book value of less than Five Hundred Thousand Dollars ($500,000); and
Collateral located in Canada, provided that such Collateral shall not have a book value in excess
of One Million Dollars ($1,000,000) at any time), which are California, Kentucky and New York.

               “Consolidated Net Income (or Deficit)” means the consolidated net income (or deficit) of any
Person and its Subsidiaries, after deduction of all expenses, taxes, and other proper charges,
determined in accordance with GAAP, after eliminating therefrom all extraordinary nonrecurring
items of income and expense (subject to Bank’s prior review and reasonable approval of such
proposed extraordinary items).

               “Consolidated Total Interest Expense” means with respect to any Person for any period, the
aggregate amount of interest required to be paid or accrued by a Person and its Subsidiaries during
such period on all Indebtedness of such Person and its Subsidiaries outstanding during all or any
part of such period, whether such interest was or is required to be reflected as an item of expense
or capitalized, including payments consisting of interest in respect of any capitalized lease or
any synthetic lease, and including commitment fees, agency fees, facility fees, balance deficiency
fees and similar fees or expenses in connection with the borrowing of money.

               “Contingent Obligation” means, as applied to any Person, any direct or indirect liability,
contingent or otherwise, of that Person with respect to (i) any indebtedness, capital lease,
dividend, letter of credit or other obligation of another, including, without limitation, any such
obligation directly or indirectly guaranteed, endorsed, co-made or discounted or sold with recourse
by that Person, or in respect of which that Person is otherwise directly or indirectly liable;
(ii) any obligations with respect to undrawn letters of credit, corporate credit cards, or merchant
services issued for the account of that Person; and (iii) all obligations arising under any
interest rate, currency or commodity swap agreement, interest rate cap agreement, interest rate
collar agreement, or other agreement or arrangement designated to protect a Person against
fluctuation in interest rates, currency exchange

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rates or commodity prices; provided, however, that the term “Contingent Obligation” shall not
include endorsements for collection or deposit in the Ordinary Course of Business. The amount of
any Contingent Obligation shall be deemed to be an amount equal to the stated or determined amount
of the primary obligation in respect of which such Contingent Obligation is made or, if not stated
or determinable, the maximum reasonably anticipated liability in respect thereof as determined by
such Person in good faith; provided, however, that such amount shall not in any event exceed the
maximum amount of the obligations under the guarantee or other support arrangement.

               “Copyrights” means any and all copyright rights, copyright applications, copyright
registrations and like protections in each work or authorship and derivative work thereof, whether
published or unpublished and whether or not the same also constitutes a trade secret, now or
hereafter existing, created, acquired or held.

               “Credit Extension” means each Advance or any other extension of credit by Bank to or for the
benefit of Borrower hereunder.

               “EBITDA” means with respect to any fiscal period an amount equal to the sum of
(a) Consolidated Net Income of the Borrower and its Subsidiaries for such fiscal period, plus
(b) in each case to the extent deducted in the calculation of the Borrower’s Consolidated Net
Income and without duplication, (i) depreciation and amortization for such period, plus (ii) income
tax expense for such period, plus (iii) Consolidated Total Interest Expense paid or accrued during
such period, plus (iv) stock-based compensation expensed in accordance with GAAP, and minus, to the
extent added in computing Consolidated Net Income, and without duplication, all extraordinary and
non-recurring revenue and gains and expenses (including income tax benefits) (subject, in all
events, to Bank’s prior review and reasonable approval of such proposed extraordinary items) for
such period, all as determined in accordance with GAAP.

               “Eligible Accounts” means those Accounts that arise in the Ordinary Course of Business that
comply with all of Borrower’s representations and warranties to Bank set forth in Section 5.3;
provided that, as the result of an audit of the Collateral which is unsatisfactory to Bank in its
reasonable discretion, or an Event of Default, Bank may change the standards of eligibility by
giving Borrower thirty (30) days prior written notice. Unless otherwise agreed to by Bank,
Eligible Accounts shall not include the following:

               (a) Accounts that the account debtor has failed to pay in full within (x) sixty (60) days of
due date with respect to Accounts payable on terms consistent with Borrower’s Trade Policy; and (y)
ninety (90) days of invoice date on all other Accounts;

               (b) Credit balances over (x) sixty (60) days with respect to Accounts payable on terms
consistent with Borrower’s Trade Policy; and (y) ninety (90) days on all other Accounts;

               (c) Accounts with respect to an account debtor, twenty-five percent (25%) of whose Accounts
the account debtor has failed to pay within (x) sixty (60) days of due date with respect to
Accounts payable on terms consistent with Borrower’s Trade Policy; and (y) ninety (90) days of
invoice date on all other Accounts;

               (d) Accounts with respect to an account debtor, including Subsidiaries and Affiliates, whose
total obligations to Borrower exceed twenty five percent (25%) of all Accounts, to the extent such
obligations exceed the aforementioned percentage; except for Accounts of McKesson Corporation,
AmerisourceBergen Corporation and Cardinal Health, Inc. (and each of their Affiliates), to the
extent the obligations (of each such Account) exceed fifty percent (50%) of all Accounts; except as
approved in writing by Bank;

               (e) Accounts with respect to which the account debtor does not have its principal place of
business in the United States, except for Eligible Foreign Accounts;

               (f) Accounts with respect to which the account debtor is the United States or any department,
agency, or instrumentality of the United States, except for Accounts of the United States if the
payee

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has assigned its payment rights to Bank and the assignment has been acknowledged under the
Assignment of Claims Act of 1940 (31 U.S.C. 3727);

               (g) Accounts with respect to which Borrower is liable to the account debtor for goods sold or
services rendered by the account debtor to Borrower, but only to the extent of any amounts owing to
the account debtor against amounts owed to Borrower;

               (h) Accounts with respect to which goods are placed on consignment, guaranteed sale, sale or
return, sale on approval, bill and hold, demo or promotional, or other terms by reason of which the
payment by the account debtor may be conditional (other than Accounts subject to return as a result
of product damage or expiration, in accordance Borrower’s Trade Policy);

               (i) Accounts with respect to which the account debtor is an officer, employee or Affiliate of
Borrower;

               (j) Accounts that have not yet been billed to the account debtor or that relate to deposits
(such as good faith deposits) or other property of the account debtor held by Borrower for the
performance of services or delivery of goods which Borrower has not yet performed or delivered;

               (k) Accounts with respect to which the account debtor disputes liability or makes any claim
with respect thereto as to which Bank believes, in its sole discretion, that there may be a basis
for dispute (but only to the extent of the amount subject to such dispute or claim), or is subject
to any Insolvency Proceeding, or becomes insolvent, or goes out of business;

               (l) Accounts the collection of which Bank reasonably determines after inquiry and consultation
with Borrower to be doubtful; and

               (m) Retentions and hold-backs.

               “Eligible Foreign Accounts” means Accounts with respect to which the account debtor does not
have its principal place of business in the United States and that are (i) supported by one or more
letters of credit in an amount and of a tenor, and issued by a financial institution, acceptable to
Bank, (ii) insured by the Export Import Bank of the United States, (iii) generated by an account
debtor with its principal place of business in Canada, provided that the Bank has perfected its
security interest in the appropriate Canadian province, or (iv) approved by Bank on a case-by-case
basis. All Eligible Foreign Accounts must be calculated in U.S. Dollars.

               “Environmental Laws” means all laws, rules, regulations, orders and the like issued by any
federal state, local foreign or other governmental or quasi-governmental authority or any agency
pertaining to the environment or to any hazardous materials or wastes, toxic substances, flammable,
explosive or radioactive materials, asbestos or other similar materials.

               “Equipment” means all present and future machinery, equipment, tenant improvements, furniture,
fixtures, vehicles, tools, parts and attachments in which Borrower has any interest.

               “ERISA” means the Employee Retirement Income Security Act of 1974, as amended, and the
regulations thereunder.

               “Event of Default” has the meaning assigned in Article 8.

               “GAAP” means generally accepted accounting principles, consistently applied, as in effect from
time to time.

               “Indebtedness” means (a) all indebtedness for borrowed money or the deferred purchase price of
property or services, including without limitation reimbursement and other obligations with respect
to surety

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bonds and letters of credit, (b) all obligations evidenced by notes, bonds, debentures or
similar instruments, (c) all capital (but not operating) lease obligations, and (d) all Contingent
Obligations.

               “Insolvency Proceeding” means any proceeding commenced by or against any Person or entity
under any provision of the United States Bankruptcy Code, as amended, or under any other bankruptcy
or insolvency law, including assignments for the benefit of creditors, formal or informal
moratoria, compositions, extension generally with its creditors, or proceedings seeking
reorganization, arrangement, or other relief.

               “Intellectual Property” means all of Borrower’s right, title, and interest in and to the
following:

               (a) Copyrights, Trademarks and Patents;

               (b) Any and all trade secrets, and any and all Intellectual Property rights in computer
software and computer software products now or hereafter existing, created, acquired or held;

               (c) Any and all design rights which may be available to Borrower now or hereafter existing,
created, acquired or held;

               (d) Any and all claims for damages by way of past, present and future infringement of any of
the rights included above, with the right, but not the obligation, to sue for and collect such
damages for said use or infringement of the Intellectual Property rights identified above;

               (e) All licenses or other rights to use any of the Copyrights, Patents or Trademarks, and all
license fees and royalties arising from such use to the extent permitted by such license or rights;

               (f) All amendments, renewals and extensions of any of the Copyrights, Trademarks or Patents;
and

               (g) All proceeds of the foregoing, including without limitation all payments under insurance
or any indemnity or warranty payable in respect of any of the foregoing.

               “Inventory” means all present and future inventory in which Borrower has any interest.

               “Investment” means any beneficial ownership of (including stock, partnership or limited
liability company interest other securities) any Person, or any loan, advance or capital
contribution to any Person.

               “IRC” means the Internal Revenue Code of 1986, as amended, and the regulations thereunder.

               “Letter of Credit” means a commercial or standby letter of credit or similar undertaking
issued by Bank at Borrower’s request.

               “LIBOR Addendum” means that certain Amended and Restated LIBOR Addendum to Amended and
Restated Loan and Security Agreement executed by and between Borrower and Bank of even date
herewith.

               “Lien” means any mortgage, lien, deed of trust, charge, pledge, security interest or other
encumbrance.

               “Liquidity” means the sum of Cash at Bank (or Bank’s Affiliates or other third parties, in
each case subject to a control agreement in form and content reasonably acceptable to Bank and
provided the Bank can view the accounts’ balances on a daily basis), plus the Borrowing Base.

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               “Loan Documents” means, collectively, this Agreement, any note or notes executed by Borrower,
and any other document, instrument or agreement entered into in connection with this Agreement, all
as amended or extended from time to time.

               “Material Adverse Effect” means a material adverse effect on (i) the business operations,
condition (financial or otherwise) or prospects of Borrower and its Subsidiaries taken as a whole,
(ii) the ability of Borrower to repay the Obligations or otherwise perform its obligations under
the Loan Documents, (iii) Borrower’s interest in, or the value, perfection or priority of Bank’s
security interest in the Collateral.

               “Negotiable Collateral” means all of Borrower’s present and future letters of credit of which
it is a beneficiary, drafts, instruments (including promissory notes), securities, documents of
title, and chattel paper, and Borrower’s Books relating to any of the foregoing.

               “Obligations” means all debt, principal, interest, Bank Expenses and other amounts owed to
Bank by Borrower pursuant to this Agreement or any other agreement, whether absolute or contingent,
due or to become due, now existing or hereafter arising, including any interest that accrues after
the commencement of an Insolvency Proceeding and including any debt, liability, or obligation owing
from Borrower to others that Bank may have obtained by assignment or otherwise.

               “Ordinary Course of Business” means, with respect to Borrower and any transaction, agreement
or other matter, engaging in the usual and customary business of a specialty pharmaceutical company
similar to Borrower in size (financial and otherwise) and business strategy (as of the Closing Date
and as contemplated as of the Closing Date), including but not limited to, entering into or
amending arrangements relating to collaborations, joint ventures, strategic alliances, product
acquisitions and the development, manufacture and commercialization of pharmaceutical products or
medical devices (including but not limited to the license (exclusive only as to duration, market
segment and/or geography) and sublicense of Intellectual Property in arms’ length transactions on
fair and reasonable terms); in each case, provided the same could not reasonably be expected to
have a Material Adverse Effect and provided further that an Event of Default has not occurred and
is not continuing before and could not reasonably be expected to occur after giving effect to such
transaction, agreement or other matter.

               “Patents” means all patents, patent applications and like protections including without
limitation improvements, divisions, continuations, renewals, reissues, extensions and
continuations-in-part of the same.

               “Periodic Payments” means all installments or similar recurring payments that Borrower may now
or hereafter become obligated to pay to Bank pursuant to the terms and provisions of any
instrument, or agreement now or hereafter in existence between Borrower and Bank.

               “Permitted Indebtedness” means:

               (a) Indebtedness of Borrower in favor of Bank arising under this Agreement or any other Loan
Document;

               (b) Indebtedness existing on the Closing Date and disclosed in the Schedule;

               (c) Indebtedness not to exceed One Million Five Hundred Thousand Dollars ($1,500,000) in the
aggregate in any fiscal year of Borrower secured by a lien described in clause (c) of the defined
term “Permitted Liens;” provided such Indebtedness does not exceed the lesser of the cost or fair
market value of the equipment financed with such Indebtedness;

               (d) Without duplication with (c), above, or clause (d) of the defined term “Permitted Liens,”
Indebtedness with respect to capital leases not to exceed Five Million Dollars ($5,000,000) in the
aggregate outstanding, resulting solely from (x) changes to GAAP which require the conversion of
leases considered

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“operating leases” as of the Closing Date to “capital leases” as of any future date or (y)
Borrower’s determination to finance or refinance assets subject to operating leases as of the
Closing Date with capital leases;

               (e) Subordinated Debt;

               (f) Indebtedness to trade creditors incurred in the Ordinary Course of Business;

               (g) Indebtedness of Borrower which (i) is convertible into shares of common stock of Borrower;
(ii) is unsecured, (iii) provides for principal payment only after the Revolving Maturity Date; and
(iv) may or may not be Subordinated Debt; and

               (h) Extensions, refinancings and renewals of any items of Permitted Indebtedness, provided
that the principal amount is not increased or the terms modified in any material respect to impose
more burdensome terms upon Borrower or its Subsidiary, as the case may be.

               “Permitted Investment” means:

               (a) Investments existing on the Closing Date disclosed in the Schedule; and

               (b) (i) Marketable direct obligations issued or unconditionally guaranteed by the United
States of America or any agency or any State thereof maturing within one (1) year from the date of
acquisition thereof, (ii) commercial paper maturing no more than one (1) year from the date of
creation thereof and currently having rating of at least A-2 or P-2 from either Standard & Poor’s
Corporation or Moody’s Investors Service, (iii) Bank’s certificates of deposit maturing no more
than one year from the date of investment therein, (iv) Bank’s money market accounts, and (v)
Investments made in accordance with Borrower’s investment policy approved from time to time by
Borrower’s board of directors and provided to (and, to the extent amended after the Closing Date,
approved by) Bank;

               (c) Repurchases of stock from former employees or directors of Borrower under the terms of
applicable repurchase agreements (i) in an aggregate amount not to exceed Two Million Five Hundred
Thousand Dollars ($2,500,000) in any fiscal year, provided that no Event of Default has occurred,
is continuing or would exist after giving effect to the repurchases, or (ii) in any amount where
the consideration for the repurchase is the cancellation of indebtedness owed by such former
employees to Borrower regardless of whether an Event of Default exists;

               (d) Investments accepted in connection with Permitted Transfers;

               (e) Investments of Subsidiaries in or to other Subsidiaries or Borrower and Investments by
Borrower in Subsidiaries not to exceed Five Hundred Thousand Dollars ($500,000) in the aggregate in
any fiscal year;

               (f) Investments not to exceed Five Hundred Thousand Dollars ($500,000) in the aggregate in any
fiscal year consisting of (i) travel advances and employee relocation loans and other employee
loans and advances in the Ordinary Course of Business, and (ii) loans to employees, officers or
directors relating to the purchase of equity securities of Borrower or its Subsidiaries pursuant to
stock option plan agreements (and similar agreements) approved by Borrower’s Board of Directors;

               (g) Investments (including debt obligations) received in connection with the bankruptcy or
reorganization of customers or suppliers and in settlement of delinquent obligations of, and other
disputes with, customers or suppliers arising in the Ordinary Course of Business;

               (h) Investments consisting of notes receivable of, or prepaid royalties and other credit
extensions, to customers and suppliers who are not Affiliates, in the Ordinary Course of Business,
provided that this subparagraph (h) shall not apply to Investments of Borrower in any Subsidiary;
and

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               (i) Transactions, agreements or other matters entered into in the Ordinary Course of Business.

               “Permitted Liens” means:

               (a) Any Liens existing on the Closing Date and disclosed in the Schedule or arising under this
Agreement or the other Loan Documents;

               (b) Liens for taxes, fees, assessments or other governmental charges or levies, either not
delinquent or being contested in good faith by appropriate proceedings and for which Borrower
maintains adequate reserves, provided the same have no priority over any of Bank’s security
interests;

               (c) Liens not to exceed One Million Five Hundred Thousand Dollars ($1,500,000) in the
aggregate in any fiscal year (i) upon or in any Equipment acquired or held by Borrower or any of
its Subsidiaries to secure the purchase price of such Equipment or indebtedness incurred solely for
the purpose of financing the acquisition or lease of such Equipment, or (ii) existing on such
Equipment at the time of its acquisition, provided that the Lien is confined solely to the property
so acquired and improvements thereon, and the proceeds of such Equipment;

               (d) Without duplication with (c), above, or clause (d) of the defined term “Permitted
Indebtedness,” Liens securing capital leases not to exceed Five Million Dollars ($5,000,000) in the
aggregate outstanding, resulting solely from (x) changes to GAAP which require the conversion of
leases considered “operating leases” as of the Closing Date to “capital leases” as of any future
date or (y) Borrower’s determination to finance or refinance assets subject to operating leases as
of the Closing Date with capital leases;

               (e) Liens incurred in connection with the extension, renewal or refinancing of the
indebtedness secured by Liens of the type described in clauses (a) through (c) above, provided that
any extension, renewal or replacement Lien shall be limited to the property encumbered by the
existing Lien and the principal amount of the indebtedness being extended, renewed or refinanced
does not increase in any material respect;

               (f) Liens arising from judgments, decrees or attachments in circumstances not constituting an
Event of Default under Sections 8.5 or 8.9;

               (g) Liens of materialmen, mechanics, warehousemen, carriers, artisans or other similar Liens
arising in the Ordinary Course of Business or by operation of law, which are not past due or which
are being contested in good faith by appropriate proceedings and for which reserves have been
established in accordance with GAAP; and

               (h) Liens in favor of other financial institutions arising in connection with Borrower’s
deposit accounts held at such institutions to secure standard fees for deposit services charged by,
but not financing made available by such institutions, provided that Bank has a perfected security
interest in the amounts held in such deposit accounts.

               “Permitted Transfer” means the conveyance, sale, lease, transfer or disposition by Borrower or
any Subsidiary of:

               (a) Inventory in the Ordinary Course of Business;

               (b) licenses and similar arrangements for the use of the Intellectual Property of Borrower or
its Subsidiaries in the Ordinary Course of Business;

               (c) worn-out or obsolete Equipment;

               (d) transfers of Borrower’s assets in the Ordinary Course of Business; or

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               (e) other assets of Borrower or its Subsidiaries that do not in the aggregate exceed Five
Hundred Thousand Dollars ($500,000) during any fiscal year.

               “Person” means any individual, sole proprietorship, partnership, limited liability company,
joint venture, trust, unincorporated organization, association, corporation, institution, public
benefit corporation, firm, joint stock company, estate, entity or governmental agency.

               “Prime Rate” means the variable rate of interest, per annum, most recently announced by Bank,
as its “prime rate,” whether or not such announced rate is the lowest rate available from Bank.

               “Profitability” means net income after tax, calculated in accordance with GAAP, plus
stock-based compensation expensed in accordance with GAAP.

               “Responsible Officer” means each of the Chief Executive Officer and the Chief Financial
Officer of Borrower.

               “Revolving Line” means a Credit Extension of up to Twenty-Five Million Dollars ($25,000,000).

               “Revolving Maturity Date” means July 11, 2011.

               “Schedule” means the schedule of exceptions attached hereto and approved by Bank, if any,
including any updates thereto in accordance with Section 3.2(b).

               “SOS Reports” means the official reports from the Secretaries of State of each Collateral
State, Chief Executive Office State and the Borrower State and other applicable federal, state or
local government offices identifying all current security interests filed in the Collateral and
Liens of record as of the date of such report.

               “Subordinated Debt” means any debt incurred by Borrower that is subordinated in writing to the
debt owing by Borrower to Bank on terms reasonably acceptable to Bank (and identified as being such
by Borrower and Bank).

               “Subsidiary” means any corporation, partnership or limited liability company or joint venture
in which (i) any general partnership interest or (ii) more than fifty percent (50%) of the stock,
limited liability company interest or joint venture of which by the terms thereof has the ordinary
voting power to elect the Board of Directors, managers or trustees of the entity, at the time as of
which any determination is being made, is owned by Borrower, either directly or through an
Affiliate.

               “Trademarks” means any trademark and servicemark rights, whether registered or not,
applications to register and registrations of the same and like protections, and the entire
goodwill of the business of Borrower connected with and symbolized by such trademarks.

               “Trade Policy” means Borrower’s policy with respect to damaged and/or expired products, as set
forth in that certain “Santarus, Inc. Trade Policy” in effect (and as contemplated) as of the
Closing Date, attached hereto as Annex I (and as amended from time to time, as approved by Bank).

          1.2 Accounting Terms. Any accounting term not specifically defined herein shall be
construed in accordance with GAAP and all calculations shall be made in accordance with GAAP. The
term “financial statements” shall include, with respect to annual and quarterly financial
statements (unless otherwise required by the SEC), the accompanying notes and schedules.

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      2. LOAN AND TERMS OF PAYMENT.

          2.1 Credit Extensions.

               (a) Promise to Pay. Borrower promises to pay to Bank, in lawful money of the United
States of America, the aggregate unpaid principal amount of all Credit Extensions made by Bank to
Borrower, together with interest on the unpaid principal amount of such Credit Extensions at rates
in accordance with the terms hereof.

               (b) Advances Under Revolving Line.

                    (i) Amount. Subject to and upon the terms and conditions of this Agreement, and, when
Advances are made against the Borrowing Base, subject to an audit of the Collateral the results of
which shall be satisfactory to Bank, (1) Borrower may request Advances, subject to Section 6.7(b)
in an aggregate outstanding amount not to exceed the Revolving Line, and (2) amounts borrowed
pursuant to this Section 2.1(b) may be repaid and reborrowed at any time prior to the Revolving
Maturity Date, at which time all Advances under this Section 2.1(b) shall be immediately due and
payable. Except as set forth in the LIBOR Addendum, Borrower may prepay any Advances without
penalty or premium.

                    (ii) Form of Request. Whenever Borrower desires an Advance, Borrower will notify Bank
by facsimile transmission or email no later than 3:00 p.m. Pacific time (1:00 p.m. Pacific time for
wire transfers), on the Business Day that the Advance is to be made. Each such notification shall
be promptly confirmed by a Loan Advance/Paydown Request Form in substantially the form of Exhibit B
hereto. Bank is authorized to make Advances under this Agreement, based upon instructions received
from a Responsible Officer or a designee of a Responsible Officer, or without instructions (but
with notice to Borrower) if in Bank’s discretion such Advances are necessary to meet Obligations
which have become due and remain unpaid. Bank shall be entitled to rely on any facsimile or email
notice given by a person who Bank reasonably believes to be a Responsible Officer or a designee
thereof, and Borrower shall indemnify and hold Bank harmless for any damages or loss suffered by
Bank as a result of such reliance. Bank will credit the amount of Advances made under this
Section 2.1(b) to Borrower’s deposit account.

          2.2 Overadvances. If the aggregate amount of the outstanding Advances exceeds the
lesser of the Revolving Line or, subject to Section 6.7(b), the Minimum Liquidity Ratio at any
time, Borrower shall immediately pay to Bank, in cash, the amount of such excess.

          2.3 Interest Rates, Payments, and Calculations.

               (a) Interest Rates. Except as set forth in Section 2.3(b), the Advances shall bear
interest, on the outstanding daily balance thereof, as set forth in the LIBOR Addendum.

               (b) Default Rate. All Obligations shall bear interest, from and after the occurrence
and during the continuance of an Event of Default, at a rate equal to three (3) percentage points
above the interest rate applicable immediately prior to the occurrence of the Event of Default.

               (c) Payments. Interest hereunder shall be due and payable in arrears on the first
calendar day of each month during the term hereof. Bank shall, at its option, charge such
interest, all Bank Expenses, and all Periodic Payments against any of Borrower’s deposit accounts
or, in the event of insufficient funds in such accounts, against the Revolving Line, in which case
those amounts shall thereafter accrue interest at the rate then applicable hereunder. Any interest
not paid when due (other than as a result of Bank’s failure to debit Borrower’s deposit accounts
when such accounts have sufficient funds) shall be compounded by becoming a part of the
Obligations, and such interest shall thereafter accrue interest at the rate then applicable
hereunder.

               (d) Computation. In the event the Prime Rate is changed from time to time hereafter,
the applicable rate of interest hereunder shall be increased or decreased, effective as of the day
the Prime Rate is changed, by an amount equal to such change in the Prime Rate. All interest
chargeable under the Loan

- 10 -

 

Documents shall be computed on the basis of a three hundred sixty (360) day year for the
actual number of days elapsed.

          2.4 Crediting Payments. Prior to the occurrence of an Event of Default, Bank shall
credit a wire transfer of funds, check or other item of payment to such deposit account or
Obligation as Borrower specifies. After the occurrence and during the continuance of an Event of
Default, Bank shall have the right, in its sole discretion, to immediately apply any wire transfer
of funds, check, or other item of payment to conditionally reduce Obligations, but such
applications of funds shall not be considered a payment on account unless such payment is of
immediately available federal funds or unless and until such check or other item of payment is
honored when presented for payment. Notwithstanding anything to the contrary contained herein, any
wire transfer or payment received by Bank after 12:00 noon Pacific time shall be deemed to have
been received by Bank as of the opening of business on the immediately following Business Day.
Whenever any payment to Bank under the Loan Documents would otherwise be due (except by reason of
acceleration) on a date that is not a Business Day, such payment shall instead be due on the next
Business Day, and additional fees or interest, as the case may be, shall accrue and be payable for
the period of such extension.

          2.5 Fees. Borrower shall pay to Bank the following:

               (a) Unused Commitment Fee. A fee equal to one half of one percent (0.50%) per annum
of the difference between the amount of the Revolving Line and the average daily balance
outstanding thereunder during the term hereof (commencing from the Closing Date), paid quarterly in
arrears, which shall be nonrefundable; and

               (b) Bank Expenses. On the Closing Date, all Bank Expenses incurred through the
Closing Date, and, after the Closing Date, all Bank Expenses as and when they become due.

          2.6 Term. This Agreement shall become effective on the Closing Date and, subject to
Section 13.7, shall continue in full force and effect for so long as any Obligations remain
outstanding or Bank has any obligation to make Credit Extensions under this Agreement.
Notwithstanding the foregoing, Bank shall have the right to terminate its obligation to make Credit
Extensions under this Agreement immediately and without notice upon the occurrence and during the
continuance of an Event of Default. Borrower shall have the right to terminate this Agreement upon
thirty (30) days prior written notice to Bank and indefeasible payment in full of the Obligations.

      3. CONDITIONS OF LOANS.

          3.1 Conditions Precedent to Initial Credit Extension. The obligation of Bank to make
the initial Credit Extension is subject to the condition precedent that Bank shall have received,
in form and substance satisfactory to Bank, the following:

               (a) this Agreement;

               (b) the LIBOR Addendum;

               (c) an officer’s certificate of Borrower with respect to incumbency and resolutions
authorizing the execution and delivery of this Agreement;

               (d) UCC National Form Financing Statement Amendment;

               (e) current SOS Reports indicating that except for Permitted Liens, there are no other
security interests or Liens of record in the Collateral;

               (f) except as set forth in the Schedule, securities and/or deposit account control agreements
with respect to any accounts permitted hereunder to be maintained outside Bank;

- 11 -

 

               (g) agreement to furnish insurance;

               (h) payment of the fees and Bank Expenses then due specified in Section 2.5 hereof;

               (i) current financial statements, including audited statements for Borrower’s most recently
ended fiscal year, together with an unqualified opinion, company prepared consolidated balance
sheets and income statements for the most recently ended quarter (as filed with the Securities and
Exchange Commission (the “SEC”)) in accordance with Section 6.2, and such other updated financial
information as Bank may reasonably request;

               (j) current Compliance Certificate in accordance with Section 6.2; and

               (k) such other documents, certificates or opinions, and completion of such other matters, as
Bank may reasonably deem necessary or appropriate.

          3.2 Conditions Precedent to all Credit Extensions. The obligation of Bank to make
each Credit Extension, including the initial Credit Extension, is further subject to the following
conditions:

               (a) timely receipt by Bank of the Loan Advance/Paydown Request Form as provided in
Section 2.1; and

               (b) the representations and warranties contained in Section 5 shall be true and correct in all
material respects on and as of the date of such Loan Advance/Paydown Request Form and on the
effective date of each Credit Extension as though made at and as of each such date, and no Event of
Default shall have occurred and be continuing, or would exist after giving effect to such Credit
Extension (provided, however, that those representations and warranties expressly referring to
another date shall be true, correct and complete in all material respects as of such date). The
making of each Credit Extension shall be deemed to be a representation and warranty by Borrower on
the date of such Credit Extension as to the accuracy of the facts referred to in this Section 3.2.
Notwithstanding the foregoing, after the initial Credit Extension, Borrower may update such
representations and warranties by amending the Schedule attached hereto for events or circumstances
arising after the initial Credit Extension so long as Bank reviews and approves such updated
information, which information could not reasonably be expected to have a Material Adverse Effect.

      4. CREATION OF SECURITY INTEREST.

          4.1 Grant of Security Interest. Borrower grants and pledges to Bank a continuing
security interest in the Collateral to secure prompt repayment of any and all Obligations and in
order to secure prompt performance by Borrower of each of its covenants and duties under the Loan
Documents. Except as set forth in the Schedule, such security interest constitutes a valid, first
priority security interest in the presently existing Collateral, and will constitute a valid, first
priority security interest in later-acquired Collateral. Borrower also hereby agrees to not sell,
transfer, assign, mortgage, pledge, lease, grant a security interest in, or encumber any of its
Intellectual Property; in each case, other than in the Ordinary Course of Business.
Notwithstanding any termination, Bank’s Lien on the Collateral shall remain in effect for so long
as any Obligations are outstanding.

          4.2 Perfection of Security Interest. Borrower authorizes Bank to file at any time
financing statements, continuation statements, and amendments thereto that (i) either specifically
describe the Collateral or describe the Collateral as all assets of Borrower of the kind pledged
hereunder, and (ii) contain any other information required by the Code for the sufficiency of
filing office acceptance of any financing statement, continuation statement, or amendment,
including whether Borrower is an organization, the type of organization and any organizational
identification number issued to Borrower, if applicable. Any such financing statements may be
signed by Bank on behalf of Borrower, as provided in the Code, and may be filed at any time in any
jurisdiction whether or not Revised Article 9 of the Code is then in effect in that jurisdiction.
Borrower shall from time to time endorse and deliver to Bank, at the request of Bank, all
Negotiable Collateral and other documents that Bank may reasonably request, in form satisfactory to
Bank, to perfect and continue perfected Bank’s security interests in the Collateral and in order to
fully consummate all of the transactions contemplated under the Loan Documents.

- 12 -

 

Borrower shall have possession of the Collateral, except where expressly otherwise provided in
this Agreement or where Bank reasonably determines to perfect its security interest by possession
in addition to the filing of a financing statement. Where Collateral is in possession of a third
party bailee, Borrower shall take such steps as Bank reasonably requests for Bank to (i) obtain an
acknowledgment, in form and substance satisfactory to Bank, of the bailee that the bailee holds
such Collateral for the benefit of Bank, and (ii) obtain “control” of any Collateral consisting of
investment property, deposit accounts, letter-of-credit rights or electronic chattel paper (as such
items and the term “control” are defined in Revised Article 9 of the Code) by causing the
securities intermediary or depositary institution or issuing bank to execute a control agreement in
form and substance satisfactory to Bank. Borrower will not create any chattel paper without
placing a legend on the chattel paper acceptable to Bank indicating that Bank has a security
interest in the chattel paper. Borrower from time to time may deposit with Bank specific cash
collateral to secure specific Obligations; Borrower authorizes Bank to hold such specific balances
in pledge and to decline to honor any drafts thereon or any request by Borrower or any other Person
to pay or otherwise transfer any part of such balances for so long as the specific Obligations are
outstanding.

          4.3 Right to Inspect. Bank (through any of its officers, employees, or agents) shall
have the right, upon reasonable prior notice, from time to time during Borrower’s usual business
hours but no more than once a year (unless an Event of Default has occurred and is continuing), to
inspect Borrower’s Books and to make copies thereof and to check, test, and appraise the Collateral
in order to verify Borrower’s financial condition or the amount, condition of, or any other matter
relating to, the Collateral.

     5. REPRESENTATIONS AND WARRANTIES.

          Borrower represents and warrants as follows:

          5.1 Due Organization and Qualification. Borrower and each Subsidiary is duly existing
under the laws of the state in which it is organized and qualified and licensed to do business in
any state in which the conduct of its business or its ownership of property requires that it be so
qualified, except where the failure to do so could not reasonably be expected to cause a Material
Adverse Effect.

          5.2 Due Authorization; No Conflict. The execution, delivery, and performance of the
Loan Documents are within Borrower’s corporate powers, have been duly authorized by all necessary
corporate action on the part of Borrower, and are not in conflict with nor constitute a breach of
any provision contained in Borrower’s Certificate of Incorporation or Bylaws, nor will they
constitute an event of default under any material agreement by which Borrower is bound. Borrower
is not in default under any agreement by which it is bound, except to the extent such default could
not reasonably be expected to cause a Material Adverse Effect.

          5.3 Collateral. Borrower has rights in or the power to transfer the Collateral, and
its title to the Collateral is free and clear of Liens, adverse claims, and restrictions on
transfer or pledge except for Permitted Liens. Other than: personal property used to support field
services and marketing operations, having an aggregate book value of less than Five Hundred
Thousand Dollars ($500,000); and Collateral located in Canada, which shall not have a book value in
excess of One Million Dollars ($1,000,000) at any time; all Collateral is located solely in the
Collateral States. The Eligible Accounts are bona fide existing obligations. The property or
services giving rise to such Eligible Accounts has been delivered or rendered to the account debtor
or its agent for immediate shipment to and unconditional acceptance by the account debtor (subject
to Borrower’s Trade Policy). Borrower has not received notice of actual or imminent Insolvency
Proceeding of any account debtor whose accounts are included in any Borrowing Base Certificate as
an Eligible Account. All Inventory is in all material respects of good and merchantable quality,
free from all material defects, except for Inventory for which adequate reserves have been made in
accordance with GAAP. Except as set forth in the Schedule, none of Borrower’s Cash is maintained
or invested with a Person other than Bank or Bank’s Affiliates.

          5.4 Intellectual Property. Borrower owns or controls the Intellectual Property
utilized in its business, except for licenses granted by Borrower in the Ordinary Course of
Business. To the best of Borrower’s knowledge, except as set forth in the Schedule, and no part of
its Intellectual Property has been judged invalid or unenforceable, in whole or in part, and no
claim has been made to Borrower that any part of its Intellectual Property violates the rights of
any third party except to the extent such claim could not reasonably be expected to cause a
Material Adverse Effect.

- 13 -

 

          5.5 Name; Location of Chief Executive Office. Except as disclosed in the Schedule,
Borrower has not done business under any name other than that specified on the signature page
hereof, and its exact legal name is as set forth in the first paragraph of this Agreement. The
chief executive office of Borrower is located in the Chief Executive Office State at the address
indicated in Section 10 hereof.

          5.6 Litigation. Except as set forth in the Schedule, there are no actions or
proceedings pending by or against Borrower or any Subsidiary before any court or administrative
agency in which a likely adverse decision could reasonably be expected to have a Material Adverse
Effect.

          5.7 No Material Adverse Change in Financial Statements. All consolidated financial
statements related to Borrower and any Subsidiary that are delivered by Borrower to Bank fairly
present in all material respects Borrower’s consolidated financial condition as of the date thereof
and Borrower’s consolidated results of operations for the period then ended. There has not been a
material adverse change in the consolidated or in the consolidating financial condition of Borrower
since the date of the most recent of such financial statements submitted to Bank (or available to
Bank on the SEC’s website).

          5.8 Solvency, Payment of Debts. Borrower is able to pay its debts (including trade
debts) as they mature; the fair saleable value of Borrower’s assets (including goodwill minus
disposition costs) exceeds the fair value of its liabilities; and Borrower is not left with
unreasonably small capital after the transactions contemplated by this Agreement. For purposes of
this Section 5.8, deferred revenue will be classified as capital.

          5.9 Compliance with Laws and Regulations. Borrower and each Subsidiary have met the
minimum funding requirements of ERISA with respect to any employee benefit plans maintained by
Borrower and subject to ERISA. No event has occurred resulting from Borrower’s failure to comply
with ERISA that is reasonably likely to result in Borrower’s incurring any liability that could
have a Material Adverse Effect. Borrower is not an “investment company” or a company “controlled”
by an “investment company” within the meaning of the Investment Company Act of 1940, as amended.
Borrower is not engaged principally, or as one of the important activities, in the business of
extending credit for the purpose of purchasing or carrying margin stock (within the meaning of
Regulations T and U of the Board of Governors of the Federal Reserve System). Borrower has
complied in all material respects with all the provisions of the Federal Fair Labor Standards Act.
Borrower is in compliance with all environmental laws, regulations and ordinances except where the
failure to comply could not reasonably be expected to have a Material Adverse Effect. Borrower has
not violated any statutes, laws, ordinances or rules applicable to it, the violation of which could
reasonably be expected to have a Material Adverse Effect. Borrower and each Subsidiary have filed
or caused to be filed all tax returns required to be filed, and have paid, or have made adequate
provision for the payment of, all taxes reflected therein except those being contested in good
faith with adequate reserves under GAAP or where the failure to file such returns or pay such taxes
could not reasonably be expected to have a Material Adverse Effect.

          5.10 Subsidiaries. Borrower does not own any stock, partnership interest or other
equity securities of any Person, except for Permitted Investments.

          5.11 Government Consents. Borrower and each Subsidiary have obtained all consents,
approvals and authorizations of, made all declarations or filings with, and given all notices to,
all governmental authorities that are necessary for the continued operation of Borrower’s business
as currently conducted, except where the failure to do so could not reasonably be expected to cause
a Material Adverse Effect.

          5.12 Inbound Licenses. Except as disclosed in the Schedule, Borrower is not a party
to, nor is bound by, any material inbound license or agreement that prohibits or otherwise
restricts Borrower from granting a security interest in Borrower’s interest in such material
inbound license or agreement or any other property.

          5.13 Full Disclosure. No representation, warranty or other statement made by Borrower
in any certificate or written statement furnished to Bank taken together with all such certificates
and written statements furnished to Bank contains any untrue statement of a material fact or omits
to state a material fact necessary in order to make the statements contained in such certificates
or statements not misleading it being recognized by Bank that the projections and forecasts
provided by Borrower in good faith and based upon reasonable assumptions are not to

- 14 -

 

be viewed as facts and that actual results during the period or periods covered by any such
projections and forecasts may differ from the projected or forecasted results.

     6. AFFIRMATIVE COVENANTS.

          Borrower covenants and agrees that, until payment in full of all outstanding Obligations, and
for so long as Bank may have any commitment to make a Credit Extension hereunder, Borrower shall do
all of the following:

          6.1 Good Standing and Government Compliance. Borrower shall maintain its and each of
its Subsidiaries’ corporate existence and good standing in the Borrower State, shall maintain
qualification and good standing in each other jurisdiction in which the failure to so qualify could
reasonably be expected to have a Material Adverse Effect, and shall furnish to Bank the
organizational identification number issued to Borrower by the authorities of the state in which
Borrower is organized, if applicable. Borrower shall meet, and shall cause each Subsidiary to
meet, the minimum funding requirements of ERISA with respect to any employee benefit plans subject
to ERISA. Borrower shall comply in all material respects with all applicable Environmental Laws,
and maintain all material permits, licenses and approvals required thereunder where the failure to
do so could have a Material Adverse Effect. Borrower shall comply, and shall cause each Subsidiary
to comply, with all statutes, laws, ordinances and government rules and regulations to which it is
subject, and shall maintain, and shall cause each of its Subsidiaries to maintain, in force all
licenses, approvals and agreements, the loss of which or failure to comply with which could
reasonably be expected to have a Material Adverse Effect.

          6.2 Financial Statements, Reports, Certificates. Borrower shall deliver the following
to Bank (provided that any such financial statements that are available to Bank on the SEC’s
website shall be deemed delivered without further action by Borrower): (i) as soon as available,
but in any event within one hundred twenty (120) days (or such earlier time as is required by the
SEC) after the end of Borrower’s fiscal year, audited consolidated financial statements of Borrower
prepared in accordance with GAAP, consistently applied, together with an opinion which is
unqualified or otherwise consented to in writing by Bank on such financial statements of an
independent certified public accounting firm reasonably acceptable to Bank; (ii) as soon as
available, but in any event within forty (40) days after the last day of each month when the
Liquidity Ratio set forth in Section 6.7(b) includes consideration of Borrower’s Eligible Accounts
(or, otherwise, forty (40) days after the end of each of Borrower’s first, second and third fiscal
quarters (or such earlier time as may be mandated by the SEC from time to time)), unaudited
financial statements of Borrower prepared in accordance with GAAP; (iii) as and when filed, all
reports on Forms 10-K and 10-Q filed with the SEC; (iv) within five (5) calendar days following
receipt of notice thereof, a report of any legal actions pending or threatened against Borrower or
any Subsidiary that could reasonably be expected to have a Material Adverse Effect (or otherwise
require the Company to report the same to the SEC); (v) within five (5) calendar days following
receipt thereof, each management letter prepared by Borrower’s independent certified public
accounting firm regarding Borrower’s management control systems; and (vi) such budgets, sales
projections, operating plans or other financial information as Bank may reasonably request from
time to time.

               (a) Within forty (40) days after the last day of each month (other than December, which shall
be thirty (30) days for drafts and seventy-five (75) days for final reporting) when the Liquidity
Ratio set forth in Section 6.7(b) includes consideration of Borrower’s Eligible Accounts, Borrower
shall deliver to Bank a Borrowing Base Certificate signed by a Responsible Officer in substantially
the form of Exhibit C hereto, together with aged listings by invoice due date of accounts
receivable and accounts payable.

               (b) Within forty (40) days after the last day of each month (other than December, which shall
be thirty (30) days for drafts and seventy-five (75) days for final reporting) when the Liquidity
Ratio set forth in Section 6.7(b) includes consideration of Borrower’s Eligible Accounts (or,
otherwise, forty (40) days after the end of each of Borrower’s first, second and third fiscal
quarters), Borrower shall deliver to Bank a Compliance Certificate certified as of the last day of
the applicable month and signed by a Responsible Officer in substantially the form of
Exhibit D hereto.

               (c) As soon as possible and in any event within five (5) calendar days after becoming aware of
the occurrence or existence of an Event of Default hereunder, a written statement of a

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Responsible Officer (or its designee) setting forth details of the Event of Default, and the
action which Borrower has taken or proposes to take with respect thereto.

               (d) Bank shall have a right from time to time hereafter to audit Borrower’s Accounts and
appraise Collateral at Borrower’s expense, provided that such audits will be conducted no more
often than every six (6) months unless an Event of Default has occurred and is continuing.

     Borrower may deliver to Bank on an electronic basis any certificates, reports or information
required pursuant to this Section 6.2, and Bank shall be entitled to rely on the information
contained in the electronic files, provided that Bank in good faith believes that the files were
delivered by a Responsible Officer or its designee. If Borrower delivers this information
electronically, it shall also deliver to Bank by U.S. Mail, reputable overnight courier service,
hand delivery, facsimile or .pdf file within five (5) Business Days of submission of the unsigned
electronic copy the certification of monthly financial statements, the Borrowing Base Certificate
and the Compliance Certificate, each bearing the physical signature of the Responsible Officer.

          6.3 Inventory; Returns. Borrower shall keep all Inventory in good and merchantable
condition, free from all material defects except for Inventory for which adequate reserves have
been made in accordance with GAAP. Returns and allowances, if any, as between Borrower and its
account debtors shall be on the same basis and in accordance with Borrower’s Trade Policy.
Borrower shall promptly notify Bank of all returns and recoveries and of all disputes and claims
involving more than Five Hundred Thousand Dollars ($500,000), other than in accordance with
Borrower’s Trade Policy.

          6.4 Taxes. Borrower shall make, and cause each Subsidiary to make, due and timely
payment or deposit of all material federal, state, and local taxes, assessments, or contributions
required of it by law, including, but not limited to, those laws concerning income taxes, F.I.C.A.,
F.U.T.A. and state disability, and will execute and deliver to Bank, on demand, proof satisfactory
to Bank indicating that Borrower or a Subsidiary has made such payments or deposits and any
appropriate certificates attesting to the payment or deposit thereof; provided that Borrower or a
Subsidiary need not make any payment if the amount or validity of such payment is contested in good
faith by appropriate proceedings and is reserved against (to the extent required by GAAP) by
Borrower.

          6.5 Insurance.

               (a) Borrower, at its expense, shall keep the Collateral insured against loss or damage by
fire, theft, explosion, sprinklers, and all other hazards and risks, and in such amounts, as
ordinarily insured against by other owners in similar businesses conducted in the locations where
Borrower’s business is conducted on the date hereof. Borrower shall also maintain liability and
other insurance in amounts and of a type that are customary to businesses similar to Borrower’s.

               (b) All such policies of insurance shall be in such form, with such companies, and in such
amounts as are reasonably satisfactory to Bank. All policies of property insurance shall contain a
lender’s loss payable endorsement, in a form reasonably satisfactory to Bank, showing Bank as an
additional loss payee, and all liability insurance policies shall show the Bank as an additional
insured and shall specify that the insurer must give at least 20 days notice to Bank before
canceling its policy for any reason. Upon Bank’s request, Borrower shall deliver to Bank certified
copies of the policies of insurance and evidence of all premium payments. If no Event of Default
has occurred and is continuing, proceeds payable under any casualty policy will, at Borrower’s
option, be payable to Borrower to replace the property subject to the claim, provided that any such
replacement property shall be deemed Collateral in which Bank has been granted a first priority
security interest. If an Event of Default has occurred and is continuing, all proceeds payable
under any such policy shall, at Bank’s option, be payable to Bank to be applied on account of the
Obligations.

          6.6 Accounts. Borrower shall maintain its primary depository and operating accounts
with Bank. Except as set forth in the Schedule, all material investment accounts and all other
accounts maintained outside of Bank or Bank’s Affiliates shall be subject to control agreements in
form and content reasonably acceptable to Bank. Bank agrees that it will not exercise control of
such accounts unless an Event of Default has occurred and is continuing.

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          6.7 Financial Covenants. Borrower shall at all times maintain the following financial
ratios and covenants:

                (a) Minimum Cash. A balance of Cash at Bank and Cash at Bank’s Affiliates (subject to
control agreements in form and content reasonably acceptable to Bank) of not less Four Million
Dollars ($4,000,000) at all times; provided that, until such time as Bank has received an audit of
the Collateral, the results of which shall be satisfactory to Bank, when Advances exceed Twenty
Million Dollars ($20,000,000), Borrower shall maintain a balance of Cash at Bank and Cash at Bank’s
Affiliates (subject to control agreements in form and content reasonably acceptable to Bank) of at
least one hundred ten percent (110%) of the amount of such Advances.

                (b) Minimum Liquidity Ratio. A ratio of Liquidity to all Indebtedness owing by
Borrower to Bank of at least (i) 1.10 to 1.00, when only Cash held at Bank and Bank’s Affiliates
(subject to control agreements in form and content reasonably acceptable to Bank) is used in the
calculation of Liquidity, or (ii) 1.25 to 1.00, at all other times; provided that, until such time
as Bank has received an audit of the Collateral, the results of which shall be satisfactory to
Bank, when Advances exceed Twenty Million Dollars ($20,000,000), Borrower shall maintain a balance
of Cash at Bank and Cash at Bank’s Affiliates (subject to control agreements in form and content
reasonably acceptable to Bank) of at least one hundred ten percent (110%) of the amount of such
Advances. Notwithstanding the foregoing, in accordance with the chart below, based upon Borrower’s
Remaining Months’ Cash (“RMC”), or Profitability, as the case may be, the Borrowing Base portion of
Borrower’s Liquidity may not (x) be included in the calculation of Borrower’s Liquidity until Bank
receives an audit of the Collateral, the results of which shall be satisfactory to Bank, or (y)
thereafter exceed the respective percentages (the “Maximum Borrowing Base Component”) of Borrower’s
Liquidity, and Borrower’s Cash must be at least the respective percentages (the “Minimum Cash
Component”) of Borrower’s Liquidity:

	 	 	 	 	 
	 	 	Minimum Cash	 	Maximum Borrowing
	Remaining Months’ Cash	 	Component	 	Base Component
	£ 18 months
	 	100%
	 	0%
	18 < RMC £ 24
	 	65% to 100%
	 	Up to 35%
	> 24 months
	 	40% to 100%
	 	Up to 60%
	2 consecutive quarters of Profitability
	 	25% to 100%
	 	Up to 75%

As used herein, “Remaining Months’ Cash” means, as of any date of determination, Cash divided by
Cash Burn. If at any time Borrower’s RMC increases or decreases sufficiently to change the level,
with respect to the chart above, at which Borrower’s RMC had been determined prior to such increase
or decrease, the Minimum Cash and Maximum Borrowing Base Components likewise shall adjust to the
corresponding percentages described above, for so long as Borrower’s RMC dictates such level.

                (c) Minimum EBITDA. When Advances are made against the Borrowing Base, an EBITDA,
measured quarterly on a trailing six (6) months basis, of not less than the amounts, and for the
periods, set forth on Annex II hereto. Bank shall have the right to reset this EBITDA covenant for
Borrower’s fiscal years 2008, 2009, 2010 and 2011, based upon Borrower’s Board of Director’s
approved and Bank reviewed fiscal year budgets to be delivered to Bank no later than December 31 of
each year, commencing December 31, 2008. Each new Minimum EBITDA covenant shall be established, in
consultation with Borrower, within thirty (30) days of Borrower’s submission of the required
budgets; provided that, if the parties cannot agree in good faith on the revised Minimum EBITDA
covenants, Bank shall have the right to establish such covenants in its good faith business
judgment.

          6.8 Consent of Inbound Licensors. Prior to entering into or becoming bound by any
material inbound license or agreement (other than such license or agreement entered into in the
Ordinary Course of Business

- 17 -

 

of Borrower), Borrower shall provide written notice to Bank of the
material terms of such license or agreement with a description of its likely impact on Borrower’s
business or financial condition.

          6.9 Creation/Acquisition of Subsidiaries. In the event Borrower or any Subsidiary
creates or acquires any Subsidiary, Borrower and such Subsidiary shall promptly notify Bank of the
creation or acquisition of such new Subsidiary and take all such action as may be reasonably
required by Bank to cause such Subsidiary to guarantee the Obligations of Borrower under the Loan
Documents and grant a continuing pledge and security interest in and to the collateral of such
Subsidiary (substantially as described on Exhibit A hereto), and Borrower shall grant and pledge to
Bank a perfected security interest in the stock, units or other evidence of ownership of such
Subsidiary.

          6.10 Further Assurances. At any time and from time to time Borrower shall execute and
deliver such further instruments and take such further action as may reasonably be requested by
Bank to effect the purposes of this Agreement.

      7. NEGATIVE COVENANTS.

          Borrower covenants and agrees that, so long as any credit hereunder shall be available and
until the outstanding Obligations are paid in full or for so long as Bank may have any commitment
to make any Credit Extensions, Borrower will not do any of the following without Bank’s prior
written consent, which shall not be unreasonably withheld:

          7.1 Dispositions. Convey, sell, lease, license, transfer or otherwise dispose of
(collectively, to “Transfer”), or permit any of its Subsidiaries to Transfer, all or any part of
its business or property, other than Permitted Transfers.

          7.2 Change in Name, Location, Executive Office, Change in Business; Change in Fiscal Year;
Change in Control. Change its name or the Borrower State or relocate its chief executive
office without thirty (30) days prior written notification to Bank; engage in any business, or
permit any of its Subsidiaries to engage in any business, other than or reasonably related or
incidental to the businesses currently engaged in by Borrower; change its fiscal year end; suffer
or permit a Change in Control.

          7.3 Mergers or Acquisitions. Merge or consolidate, or permit any of its Subsidiaries
to merge or consolidate, with or into any other business organization (other than mergers or
consolidations of a Subsidiary into another Subsidiary or into Borrower), or acquire, or permit any
of its Subsidiaries to acquire, all or substantially all of the capital stock or property of
another Person except transactions in the Ordinary Course of Business, where (i) such transactions
do not in the aggregate exceed Five Million Dollars ($5,000,000) during any fiscal year, (ii) no
Event of Default has occurred, is continuing or would exist after giving effect to such
transactions, (iii) such transactions do not result in a Change in Control, and (iv) Borrower is
the surviving entity.

          7.4 Indebtedness. Create, incur, assume, guarantee or be or remain liable with
respect to any Indebtedness, or permit any Subsidiary so to do, other than Permitted Indebtedness,
or prepay any Indebtedness or take any actions which impose on Borrower an obligation to prepay any
Indebtedness, except Indebtedness to Bank and Indebtedness incurred in the Ordinary Course of
Business (provided that  no Event of Default has occurred, is continuing or would exist after
giving effect to such prepayment).

          7.5 Encumbrances. Create, incur, assume or allow any Lien with respect to any of its
property, or assign or otherwise convey any right to receive income, including the sale of any
Accounts, or permit any of its Subsidiaries so to do, except for Permitted Liens. Agree with any
Person other than Bank not to grant a security interest in, or otherwise encumber, any of its, or
covenant to any other Person that Borrower in the future will refrain from creating, incurring,
assuming or allowing any Lien with respect to any of Borrower’s property, or permit any Subsidiary
to do so; other than in connection with licenses and similar arrangements for the use of the
Intellectual Property of Borrower or its Subsidiaries in the Ordinary Course of Business.

- 18 -

 

          7.6 Distributions. Pay any dividends or make any other distribution or payment on
account of or in redemption, retirement or purchase of any capital stock, except that Borrower may
(i) repurchase the stock of former employees pursuant to stock repurchase agreements as long as an
Event of Default does not exist prior to such repurchase or would not exist after giving effect to
such repurchase, and (ii) repurchase the stock of former employees pursuant to stock repurchase
agreements by the cancellation of indebtedness owed by such former employees to Borrower regardless
of whether an Event of Default exists.

          7.7 Investments. Directly or indirectly acquire or own, or make any material
Investment in or to any Person, or permit any of its Subsidiaries so to do, other than Permitted
Investments, or maintain or invest any of its property with a Person other than Bank or Bank’s
Affiliates or permit any Subsidiary to do so unless such Person has entered into a control
agreement with Bank, in form and substance satisfactory to Bank, or suffer or permit any Subsidiary
to be a party to, or be bound by, an agreement that restricts such Subsidiary from paying dividends
or otherwise distributing property to Borrower.

          7.8 Transactions with Affiliates. Directly or indirectly enter into or permit to
exist any material transaction with any Affiliate of Borrower except for transactions that are in
the Ordinary Course of Business, upon fair and reasonable terms that are no less favorable to
Borrower than would be obtained in an arm’s length transaction with a non-affiliated Person, which
permitted transactions shall include, without limitation, reasonable and customary fees to its
directors and compensation arrangements and benefit plans for its officers and employees.

          7.9 Subordinated Debt. Make any payment in respect of any Subordinated Debt, or
permit any of its Subsidiaries to make any such payment, except in compliance with the terms of
such Subordinated Debt, or amend any provision affecting Bank’s rights contained in any
documentation relating to the Subordinated Debt without Bank’s prior written consent.

          7.10 Inventory and Equipment. Store the Inventory or the Equipment having a book
value of One Million Dollars ($1,000,000) or more with a bailee, warehouseman, or similar third
party unless the third party has been notified of Bank’s security interest and Bank (a) has
received an acknowledgment from the third party that it is holding or will hold the Inventory or
Equipment for Bank’s benefit or (b) is in possession of the warehouse receipt, where negotiable,
covering such Inventory or Equipment. Except for Inventory sold in the Ordinary Course of Business
and except for such other locations as Bank may approve in writing, Borrower shall keep the
Inventory and Equipment only at the location set forth in Section 10 and such other locations of
which Borrower gives Bank prior written notice and as to which Bank files a financing statement, or
takes other action, where needed to perfect its security interest. Notwithstanding the foregoing,
Borrower shall cause each of Integrated Commercialization Services and OSG Norwich to execute and
deliver to Bank, within sixty (60) days of the Closing Date, a bailee agreement (or similar) in
form and content reasonably acceptable to Bank.

          7.11 No Investment Company; Margin Regulation. Become or be controlled by an
“investment company,” within the meaning of the Investment Company Act of 1940, or become
principally engaged in, or undertake as one of its important activities, the business of extending
credit for the purpose of purchasing or carrying margin stock, or use the proceeds of any Credit
Extension for such purpose.

      8. EVENTS OF DEFAULT.

          Any one or more of the following events shall constitute an Event of Default by Borrower under
this Agreement:

          8.1 Payment Default. If Borrower fails to pay any of the Obligations within three (3)
calendar days of the date when due;

          8.2 Covenant Default. If Borrower fails to perform any obligation under Article 6 or
violates any of the covenants contained in Article 7 of this Agreement; or neglects to perform or
observe any other material term, provision, condition, covenant contained in this Agreement, in any
of the Loan Documents, or in any other present or future agreement between Borrower and Bank and as
to any default under such other term, provision,

- 19 -

 

condition or covenant that can be cured, has failed to cure such default within fifteen (15)
days after Borrower receives notice thereof or any Responsible Officer of Borrower (or Borrower’s
General Counsel) becomes aware thereof; provided, however, that if the default cannot by its nature
be cured within the fifteen (15) day period or cannot after diligent attempts by Borrower be cured
within such fifteen (15) day period, and such default is likely to be cured within a reasonable
time, then Borrower shall have an additional reasonable period (which shall not in any case exceed
thirty (30) days) to attempt to cure such default, and within such reasonable time period the
failure to have cured such default shall not be deemed an Event of Default but no Credit Extensions
will be made;

          8.3 Defective Perfection. If Bank shall receive at any time following the Closing
Date an SOS Report indicating that except for Permitted Liens, Bank’s security interest in the
Collateral is not prior to all other security interests or Liens of record reflected in such SOS
Report;

          8.4 Material Adverse Effect. If there occurs any circumstance or circumstances that
could reasonably be expected to have a Material Adverse Effect;

          8.5 Attachment. If any material portion of Borrower’s assets is attached, seized,
subjected to a writ or distress warrant, or is levied upon, or comes into the possession of any
trustee, receiver or person acting in a similar capacity and such attachment, seizure, writ or
distress warrant or levy has not been removed, discharged or rescinded within ten (10) days, or if
Borrower is enjoined, restrained, or in any way prevented by court order from continuing to conduct
all or any material part of its business affairs, or if a judgment or other claim becomes a lien or
encumbrance upon any material portion of Borrower’s assets, or if a notice of lien, levy, or
assessment is filed of record with respect to any of Borrower’s assets by the United States
Government, or any department, agency, or instrumentality thereof, or by any state, county,
municipal, or governmental agency, and the same is not paid within ten (10) days after Borrower
receives notice thereof, provided that none of the foregoing shall constitute an Event of Default
where such action or event is stayed or an adequate bond has been posted pending a good faith
contest by Borrower (provided that no Credit Extensions will be made during such cure period);

          8.6 Insolvency. If Borrower becomes insolvent, or if an Insolvency Proceeding is
commenced by Borrower, or if an Insolvency Proceeding is commenced against Borrower and is not
dismissed or stayed within thirty (30) days (provided that no Credit Extensions will be made prior
to the dismissal of such Insolvency Proceeding);

          8.7 Other Agreements. If there is a default or other failure to perform in any
agreement to which Borrower is a party with a third party or parties resulting in a right by such
third party or parties, whether or not exercised, to accelerate the maturity of any Indebtedness in
an amount in excess of One Million Five Hundred Thousand Dollars ($1,500,000) or that could
reasonably be expected to have a Material Adverse Effect;

          8.8 Subordinated Debt. If Borrower makes any payment on account of Subordinated Debt,
except to the extent such payment is allowed under any subordination agreement entered into with
Bank;

          8.9 Judgments. If an uninsured judgment or uninsured judgments for the payment of
money in an amount, individually or in the aggregate, of at least Five Hundred Thousand Dollars
($500,000) shall be rendered against Borrower and shall remain unsatisfied and unstayed for a
period of fifteen (15) days (provided that no Credit Extensions will be made prior to the
satisfaction or stay of such judgment); or

          8.10 Misrepresentations. If any material misrepresentation or material misstatement
exists now or hereafter in any warranty or representation set forth herein or in any certificate
delivered to Bank by any Responsible Officer pursuant to this Agreement or to induce Bank to enter
into this Agreement or any other Loan Document.

      9. BANK’S RIGHTS AND REMEDIES.

          9.1 Rights and Remedies. Upon the occurrence and during the continuance of an Event
of Default, Bank may, at its election, without notice of its election and without demand, do any
one or more of the following, all of which are authorized by Borrower:

- 20 -

 

               (a) Declare all Obligations, whether evidenced by this Agreement, by any of the other Loan
Documents, or otherwise, immediately due and payable (provided that upon the occurrence of an Event
of Default described in Section 8.6, all Obligations shall become immediately due and payable
without any action by Bank);

               (b) Demand that Borrower (i) deposit cash with Bank in an amount equal to the amount of any
Letters of Credit remaining undrawn, as collateral security for the repayment of any future
drawings under such Letters of Credit, and (ii) pay in advance all Letter of Credit fees scheduled
to be paid or payable over the remaining term of the Letters of Credit, and Borrower shall promptly
deposit and pay such amounts;

               (c) Cease advancing money or extending credit to or for the benefit of Borrower under this
Agreement or under any other agreement between Borrower and Bank;

               (d) Settle or adjust disputes and claims directly with account debtors for amounts, upon terms
and in whatever order that Bank reasonably considers advisable;

               (e) Make such payments and do such acts as Bank considers necessary or reasonable to protect
its security interest in the Collateral. Borrower agrees to assemble the Collateral if Bank so
requires, and to make the Collateral available to Bank as Bank may designate. Borrower authorizes
Bank to enter the premises where the Collateral is located, to take and maintain possession of the
Collateral, or any part of it, and to pay, purchase, contest, or compromise any encumbrance,
charge, or lien which in Bank’s determination appears to be prior or superior to its security
interest and to pay all expenses incurred in connection therewith. With respect to any of
Borrower’s owned premises, Borrower hereby grants Bank a license to enter into possession of such
premises and to occupy the same, without charge, in order to exercise any of Bank’s rights or
remedies provided herein, at law, in equity, or otherwise;

               (f) Set off and apply to the Obligations any and all (i) balances and deposits of Borrower
held by Bank, and (ii) indebtedness at any time owing to or for the credit or the account of
Borrower held by Bank;

               (g) Ship, reclaim, recover, store, finish, maintain, repair, prepare for sale, advertise for
sale, and sell (in the manner provided for herein) the Collateral. Except to the extent Borrower
is prohibited by an enforceable license from doing so, Bank is hereby granted a license or other
right, solely pursuant to the provisions of this Section 9.1, to use, without charge, Borrower’s
labels, Intellectual Property, and advertising matter, or any property of a similar nature, as it
pertains to the Collateral, in completing production of, advertising for sale, and selling any
Collateral and, in connection with Bank’s exercise of its rights under this Section 9.1, Borrower’s
rights under all licenses and all franchise agreements shall inure to Bank’s benefit;

               (h) Sell the Collateral at either a public or private sale, or both, by way of one or more
contracts or transactions, for cash or on terms, in such manner and at such places (including
Borrower’s premises) as Bank determines is commercially reasonable, and apply any proceeds to the
Obligations in whatever manner or order Bank deems appropriate. Bank may sell the Collateral
without giving any warranties as to the Collateral. Bank may specifically disclaim any warranties
of title or the like. This procedure will not be considered adversely to affect the commercial
reasonableness of any sale of the Collateral. If Bank sells any of the Collateral upon credit,
Borrower will be credited only with payments actually made by the purchaser, received by Bank, and
applied to the indebtedness of the purchaser. If the purchaser fails to pay for the Collateral,
Bank may resell the Collateral and Borrower shall be credited with the proceeds of the sale;

               (i) Bank may credit bid and purchase at any public sale;

               (j) Apply for the appointment of a receiver, trustee, liquidator or conservator of the
Collateral, without notice and without regard to the adequacy of the security for the Obligations
and without regard to the solvency of Borrower, any guarantor or any other Person liable for any of
the Obligations; and

- 21 -

 

               (k) Any deficiency that exists after disposition of the Collateral as provided above will be
paid immediately by Borrower.

Bank may comply with any applicable state or federal law requirements in connection with a
disposition of the Collateral and compliance will not be considered adversely to affect the
commercial reasonableness of any sale of the Collateral.

          9.2 Power of Attorney. Effective only upon the occurrence and during the continuance
of an Event of Default, Borrower hereby irrevocably appoints Bank (and any of Bank’s designated
officers, or employees) as Borrower’s true and lawful attorney to: (a) send requests for
verification of Accounts or notify account debtors of Bank’s security interest in the Accounts;
(b) endorse Borrower’s name on any checks or other forms of payment or security that may come into
Bank’s possession; (c) sign Borrower’s name on any invoice or bill of lading relating to any
Account, drafts against account debtors, schedules and assignments of Accounts, verifications of
Accounts, and notices to account debtors; (d) dispose of any Collateral; (e) make, settle, and
adjust all claims under and decisions with respect to Borrower’s policies of insurance; (f) settle
and adjust disputes and claims respecting the accounts directly with account debtors, for amounts
and upon terms which Bank determines to be reasonable; and (g) to file, in its sole discretion, one
or more financing or continuation statements and amendments thereto, relative to any of the
Collateral without the signature of Borrower where permitted by law; provided Bank may exercise
such power of attorney to sign the name of Borrower on any of the documents described in clause (g)
above, regardless of whether an Event of Default has occurred. The appointment of Bank as
Borrower’s attorney in fact, and each and every one of Bank’s rights and powers, being coupled with
an interest, is irrevocable until all of the Obligations have been fully repaid and performed and
Bank’s obligation to provide Credit Extensions hereunder is terminated.

          9.3 Accounts Collection. At any time after the occurrence and during the continuance
of an Event of Default, Bank may notify any Person owing funds to Borrower of Bank’s security
interest in such funds and verify the amount of such Account. Borrower shall collect all amounts
owing to Borrower for Bank, receive in trust all payments as Bank’s trustee, and immediately
deliver such payments to Bank in their original form as received from the account debtor, with
proper endorsements for deposit.

          9.4 Bank Expenses. If Borrower fails to pay any amounts or furnish any required proof
of payment due to third persons or entities, as required under the terms of this Agreement, then
Bank may do any or all of the following after reasonable notice to Borrower: (a) make payment of
the same or any part thereof; (b) set up such reserves under the Revolving Line as Bank deems
necessary to protect Bank from the exposure created by such failure; or (c) obtain and maintain
insurance policies of the type discussed in Section 6.5 of this Agreement, and take any action with
respect to such policies as Bank deems prudent. Any amounts so paid or deposited by Bank shall
constitute Bank Expenses, shall be immediately due and payable, and shall bear interest at the then
applicable rate hereinabove provided, and shall be secured by the Collateral. Any payments made by
Bank shall not constitute an agreement by Bank to make similar payments in the future or a waiver
by Bank of any Event of Default under this Agreement.

          9.5 Bank’s Liability for Collateral. As long as Bank complies with reasonable banking
practices, Bank has no obligation to clean up or otherwise prepare the Collateral for sale. All
risk of loss, damage or destruction of the Collateral shall be borne by Borrower, except to the
extent caused by Bank’s gross negligence or willful misconduct.

          9.6 No Obligation to Pursue Others. Bank has no obligation to attempt to satisfy the
Obligations by collecting them from any other Person liable for them and Bank may release, modify
or waive any collateral provided by any other Person to secure any of the Obligations, all without
affecting Bank’s rights against Borrower. Borrower waives any right it may have to require Bank to
pursue any other Person for any of the Obligations.

          9.7 Remedies Cumulative. Bank’s rights and remedies under this Agreement, the Loan
Documents, and all other agreements shall be cumulative. Bank shall have all other rights and
remedies not inconsistent herewith as provided under the Code, by law, or in equity. No exercise
by Bank of one right or remedy shall be deemed an election, and no waiver by Bank of any Event of
Default on Borrower’s part shall be deemed a continuing waiver. No delay by Bank shall constitute
a waiver, election, or acquiescence by it. No waiver by Bank

- 22 -

 

shall be effective unless made in a written document signed on behalf of Bank and then shall
be effective only in the specific instance and for the specific purpose for which it was given.
Borrower expressly agrees that this Section may not be waived or modified by Bank by course of
performance, conduct, estoppel or otherwise.

          9.8 Demand; Protest. Except as otherwise provided in this Agreement, Borrower waives
demand, protest, notice of protest, notice of default or dishonor, notice of payment and nonpayment
and any other notices relating to the Obligations.

      10. NOTICES.

            Unless otherwise provided in this Agreement, all notices or demands by any party relating to
this Agreement or any other agreement entered into in connection herewith shall be in writing and
(except for financial statements and other informational documents which may be sent by first-class
mail, postage prepaid) shall be personally delivered or sent by a recognized overnight delivery
service, certified mail, postage prepaid, return receipt requested, or by telefacsimile to Borrower
or to Bank, as the case may be, at its addresses set forth below:

	 	 	 	 	 
	 

	 	If to Borrower:
	 	SANTARUS, INC.
	 

	 	 	 	3721 Valley Centre Drive, Suite 400
	 

	 	 	 	San Diego, CA 92130
	 

	 	 	 	Attn: Chief Financial Officer and Legal Affairs Department
	 

	 	 	 	FAX: (858) 314-5702
	 
	 	 	 	 
	 

	 	If to Bank:
	 	Comerica Bank
	 

	 	 	 	75 East Trimble Road, M/C 4770
	 

	 	 	 	San Jose, California 95131
	 

	 	 	 	Attn: Manager
	 

	 	 	 	FAX: (408) 556-5091
	 
	 	 	 	 
	 

	 	with a copy to:
	 	Comerica Bank
	 

	 	 	 	11943 El Camino Real, Suite 110B
	 

	 	 	 	San Diego, CA 92130
	 

	 	 	 	Attn: Steven J. Stuckey, Senior Vice President
	 

	 	 	 	FAX: (858) 509-2365

     The parties hereto may change the address at which they are to receive notices hereunder, by
notice in writing in the foregoing manner given to the other.

     11. CHOICE OF LAW AND VENUE; JURY TRIAL WAIVER.

     This Agreement shall be governed by, and construed in accordance with, the internal laws of
the State of California, without regard to principles of conflicts of law. Each of Borrower and
Bank hereby submits to the exclusive jurisdiction of the state and Federal courts located in the
State of California. THE UNDERSIGNED ACKNOWLEDGE THAT THE RIGHT TO TRIAL BY JURY IS A
CONSTITUTIONAL ONE, BUT THAT IT MAY BE WAIVED UNDER CERTAIN CIRCUMSTANCES. TO THE EXTENT PERMITTED
BY LAW, EACH PARTY, AFTER CONSULTING (OR HAVING HAD THE OPPORTUNITY TO CONSULT) WITH COUNSEL OF
ITS, HIS OR HER CHOICE, KNOWINGLY AND VOLUNTARILY, AND FOR THE MUTUAL BENEFIT OF ALL PARTIES,
WAIVES ANY RIGHT TO TRIAL BY JURY IN THE EVENT OF LITIGATION ARISING OUT OF OR RELATED TO THIS
AGREEMENT OR ANY OTHER DOCUMENT, INSTRUMENT OR AGREEMENT BETWEEN THE UNDERSIGNED PARTIES.

     12. REFERENCE PROVISION.

          In the event the Jury Trial Waiver set forth above is not enforceable, the parties elect to
proceed under this Judicial Reference Provision.

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          12.1 Mechanics.

               (a) With the exception of the items specified in clause (b), below, any controversy, dispute
or claim (each, a “Claim”) between the parties arising out of or relating to this Agreement or any
other document, instrument or agreement between the undersigned parties (collectively in this
Section, the “Comerica Documents”), will be resolved by a reference proceeding in California in
accordance with the provisions of Sections 638 et seq. of the California Code of Civil Procedure
(“CCP”), or their successor sections, which shall constitute the exclusive remedy for the
resolution of any Claim, including whether the Claim is subject to the reference proceeding. Except
as otherwise provided in the Comerica Documents, venue for the reference proceeding will be in the
state or federal court in the county or district where the real property involved in the action, if
any, is located or in the state or federal court in the county or district where venue is otherwise
appropriate under applicable law (the “Court”).

               (b) The matters that shall not be subject to a reference are the following: (i) nonjudicial
foreclosure of any security interests in real or personal property, (ii) exercise of self-help
remedies (including, without limitation, set-off), (iii) appointment of a receiver and (iv)
temporary, provisional or ancillary remedies (including, without limitation, writs of attachment,
writs of possession, temporary restraining orders or preliminary injunctions). This reference
provision does not limit the right of any party to exercise or oppose any of the rights and
remedies described in clauses (i) and (ii) or to seek or oppose from a court of competent
jurisdiction any of the items described in clauses (iii) and (iv). The exercise of, or opposition
to, any of those items does not waive the right of any party to a reference pursuant to this
reference provision as provided herein.

               (c) The referee shall be a retired judge or justice selected by mutual written agreement of
the parties. If the parties do not agree within ten (10) days of a written request to do so by any
party, then, upon request of any party, the referee shall be selected by the Presiding Judge of the
Court (or his or her representative). A request for appointment of a referee may be heard on an ex
parte or expedited basis, and the parties agree that irreparable harm would result if ex parte
relief is not granted. Pursuant to CCP § 170.6, each party shall have one peremptory challenge to
the referee selected by the Presiding Judge of the Court (or his or her representative).

               (d) The parties agree that time is of the essence in conducting the reference proceedings.
Accordingly, the referee shall be requested, subject to change in the time periods specified herein
for good cause shown, to (i) set the matter for a status and trial-setting conference within
fifteen (15) days after the date of selection of the referee, (ii) if practicable, try all issues
of law or fact within one hundred twenty (120) days after the date of the conference and (iii)
report a statement of decision within twenty (20) days after the matter has been submitted for
decision.

               (e) The referee will have power to expand or limit the amount and duration of discovery. The
referee may set or extend discovery deadlines or cutoffs for good cause, including a party’s
failure to provide requested discovery for any reason whatsoever. Unless otherwise ordered based
upon good cause shown, no party shall be entitled to “priority” in conducting discovery,
depositions may be taken by either party upon seven (7) days written notice, and all other
discovery shall be responded to within fifteen (15) days after service. All disputes relating to
discovery which cannot be resolved by the parties shall be submitted to the referee whose decision
shall be final and binding.

          12.2 Procedures. Except as expressly set forth herein, the referee shall determine
the manner in which the reference proceeding is conducted including the time and place of hearings,
the order of presentation of evidence, and all other questions that arise with respect to the
course of the reference proceeding. All proceedings and hearings conducted before the referee,
except for trial, shall be conducted without a court reporter, except that when any party so
requests, a court reporter will be used at any hearing conducted before the referee, and the
referee will be provided a courtesy copy of the transcript. The party making such a request shall
have the obligation to arrange for and pay the court reporter. Subject to the referee’s power to
award costs to the prevailing party, the parties will equally share the cost of the referee and the
court reporter at trial.

          12.3 Application of Law. The referee shall be required to determine all issues in
accordance with existing case law and the statutory laws of the State of California. The rules of
evidence applicable to

- 24 -

 

proceedings at law in the State of California will be applicable to the reference proceeding.
The referee shall be empowered to enter equitable as well as legal relief, enter equitable orders
that will be binding on the parties and rule on any motion which would be authorized in a court
proceeding, including without limitation motions for summary judgment or summary adjudication. The
referee shall issue a decision at the close of the reference proceeding which disposes of all
claims of the parties that are the subject of the reference. Pursuant to CCP § 644, such decision
shall be entered by the Court as a judgment or an order in the same manner as if the action had
been tried by the Court and any such decision will be final, binding and conclusive. The parties
reserve the right to appeal from the final judgment or order or from any appealable decision or
order entered by the referee. The parties reserve the right to findings of fact, conclusions of
laws, a written statement of decision, and the right to move for a new trial or a different
judgment, which new trial, if granted, is also to be a reference proceeding under this provision.

          12.4 Repeal. If the enabling legislation which provides for appointment of a referee
is repealed (and no successor statute is enacted), any dispute between the parties that would
otherwise be determined by reference procedure will be resolved and determined by arbitration.
The arbitration will be conducted by a retired judge or justice, in accordance with the California
Arbitration Act §1280 through §1294.2 of the CCP as amended from time to time. The limitations with
respect to discovery set forth above shall apply to any such arbitration proceeding.

          12.5 THE PARTIES RECOGNIZE AND AGREE THAT ALL CONTROVERSIES, DISPUTES AND CLAIMS RESOLVED
UNDER THIS REFERENCE PROVISION WILL BE DECIDED BY A REFEREE AND NOT BY A JURY. AFTER CONSULTING (OR
HAVING HAD THE OPPORTUNITY TO CONSULT) WITH COUNSEL OF ITS, HIS OR HER OWN CHOICE, EACH PARTY
KNOWINGLY AND VOLUNTARILY, AND FOR THE MUTUAL BENEFIT OF ALL PARTIES, AGREES THAT THIS REFERENCE
PROVISION WILL APPLY TO ANY CONTROVERSY, DISPUTE OR CLAIM BETWEEN OR AMONG THEM ARISING OUT OF OR
IN ANY WAY RELATED TO, THIS AGREEMENT OR THE OTHER COMERICA DOCUMENTS.

     13. GENERAL PROVISIONS.

          13.1 Successors and Assigns. This Agreement shall bind and inure to the benefit of
the respective successors and permitted assigns of each of the parties and shall bind all Persons
who become bound as a debtor to this Agreement; provided, however, that neither this Agreement nor
any rights hereunder may be assigned by Borrower without Bank’s prior written consent, which
consent may be granted or withheld in Bank’s sole discretion. Bank shall have the right without
the consent of or notice to Borrower to sell, transfer, negotiate, or grant participation in all or
any part of, or any interest in, Bank’s obligations, rights and benefits hereunder.

          13.2 Indemnification. Borrower shall defend, indemnify and hold harmless Bank and its
officers, employees, and agents against: (a) all obligations, demands, claims, and liabilities
claimed or asserted by any other party in connection with the transactions contemplated by this
Agreement; and (b) all losses or Bank Expenses in any way suffered, incurred, or paid by Bank, its
officers, employees and agents as a result of or in any way arising out of, following, or
consequential to transactions between Bank and Borrower whether under this Agreement, or otherwise
(including without limitation reasonable attorneys’ fees and expenses), except for losses caused by
Bank’s gross negligence or willful misconduct.

          13.3 Time of Essence. Time is of the essence for the performance of all obligations
set forth in this Agreement.

          13.4 Severability of Provisions. Each provision of this Agreement shall be severable
from every other provision of this Agreement for the purpose of determining the legal
enforceability of any specific provision.

          13.5 Amendments in Writing, Integration. All amendments to or terminations of this
Agreement or the other Loan Documents must be in writing. All prior agreements, understandings,
representations, warranties, and negotiations between the parties hereto with respect to the
subject matter of this Agreement and the other Loan Documents, if any, are merged into this
Agreement and the Loan Documents.

- 25 -

 

          13.6 Counterparts. This Agreement may be executed in any number of counterparts and
by different parties on separate counterparts, each of which, when executed and delivered, shall be
deemed to be an original, and all of which, when taken together, shall constitute but one and the
same Agreement.

          13.7 Survival. All covenants, representations and warranties made in this Agreement
shall continue in full force and effect so long as any Obligations remain outstanding or Bank has
any obligation to make any Credit Extension to Borrower. The obligations of Borrower to indemnify
Bank with respect to the expenses, damages, losses, costs and liabilities described in Section 13.2
shall survive until all applicable statute of limitations periods with respect to actions that may
be brought against Bank have run.

          13.8 Confidentiality. In handling any confidential information, Bank and all
employees and agents of Bank shall exercise the same degree of care that Bank exercises with
respect to its own proprietary information of the same types to maintain the confidentiality of any
non-public information thereby received or received pursuant to this Agreement except that
disclosure of such information may be made (i) to the subsidiaries or Affiliates of Bank in
connection with their present or prospective business relations with Borrower, (ii) to prospective
transferees or purchasers of any interest in the Credit Extensions, provided that they have entered
into a comparable confidentiality agreement in favor of Borrower and have delivered a copy to
Borrower, (iii) as required by law, regulations, rule or order, subpoena, judicial order or similar
order, (iv) as may be required in connection with the examination, audit or similar investigation
of Bank and (v) as Bank may determine in connection with the enforcement of any remedies hereunder.
Confidential information hereunder shall not include information that either: (a) is in the
public domain or in the knowledge or possession of Bank when disclosed to Bank, or becomes part of
the public domain after disclosure to Bank through no fault of Bank; or (b) is disclosed to Bank by
a third party, provided Bank does not have actual knowledge that such third party is prohibited
from disclosing such information.

          13.9 Effect of Amendment and Restatement. Except as otherwise set forth herein, this
Agreement is intended to and does completely amend and restate, without novation, the Original
Agreement. All security interests granted under the Original Agreement are hereby confirmed and
ratified and shall continue to secure all Obligations under this Agreement.

[Balance of Page Intentionally Left Blank]

- 26 -

 

     IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed as of the
date first above written.

	 	 	 	 	 
	 	 	SANTARUS, INC.
	 
	 	 	 	 
	 

	 	By: 
	/s/ Debra P. Crawford
	 

	 	 	 
	 
	 	 	 	 
	 

	 	Title: 
	SVP & CFO
	 
	 	 	 	 
	 	 	COMERICA BANK
	 
	 	 	 	 
	 

	 	By: 
	/s/ Steven J. Stuckey
	 

	 	 	 
	 
	 	 	 	 
	 

	 	Title: 
	Senior Vice President

[Signature Page to Amended and Restated Loan and Security Agreement]

 

 

	 	 	 
	DEBTOR

	 	SANTARUS, INC.
	 
	 	 
	SECURED PARTY:

	 	COMERICA BANK

EXHIBIT A

COLLATERAL DESCRIPTION ATTACHMENT

TO AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT

     All personal property of Borrower (herein referred to as “Borrower” or “Debtor”) whether
presently existing or hereafter created or acquired, and wherever located, including, but not
limited to:

          (a) all accounts (including health-care-insurance receivables), chattel paper (including
tangible and electronic chattel paper), deposit accounts, documents (including negotiable
documents), equipment (including all accessions and additions thereto), general intangibles
(including payment intangibles and software), goods (including fixtures), instruments (including
promissory notes), inventory (including all goods held for sale or lease or to be furnished under a
contract of service, and including returns and repossessions), investment property (including
securities and securities entitlements), Negotiable Collateral, letter of credit rights, money, and
all of Debtor’s books and records with respect to any of the foregoing, and the computers and
equipment containing said books and records;

          (b) any and all cash proceeds and/or noncash proceeds of any of the foregoing, including,
without limitation, insurance proceeds, and all supporting obligations and the security therefor or
for any right to payment. All terms above have the meanings given to them in the California
Uniform Commercial Code, as amended or supplemented from time to time, including revised Division 9
of the Uniform Commercial Code-Secured Transactions, added by Stats. 1999, c.991 (S.B. 45),
Section 35, operative July 1, 2001.

          Notwithstanding the foregoing, the Collateral shall not include any Intellectual Property;
provided, however, that the Collateral shall include all accounts and general intangibles that
consist of rights to payment and proceeds from the sale, licensing or disposition of all or any
part, or rights in, the foregoing (the “Rights to Payment”). Notwithstanding the foregoing, if a
judicial authority (including a U.S. Bankruptcy Court) holds that a security interest in the
underlying Intellectual Property is necessary to have a security interest in the Rights to Payment,
then the Collateral shall automatically, and effective as of the Closing Date, include the
Intellectual Property to the extent and only to the extent necessary to permit perfection of Bank’s
security interest in the Rights to Payment, and further provided, however, that Bank’s enforcement
rights with respect to any security interest in the Intellectual Property shall be absolutely
limited to the Rights to Payment only, and Bank shall have no recourse whatsoever with respect to
the underlying Intellectual Property.

               As used herein, “Intellectual Property” means all of Borrower’s right, title, and interest in
and to the following:

               (a) Copyrights, Trademarks and Patents;

               (b) Any and all trade secrets, and any and all Intellectual Property rights in computer
software and computer software products now or hereafter existing, created, acquired or held;

               (c) Any and all design rights which may be available to Borrower now or hereafter existing,
created, acquired or held;

               (d) Any and all claims for damages by way of past, present and future infringement of any of
the rights included above, with the right, but not the obligation, to sue for and collect such
damages for said use or infringement of the Intellectual Property rights identified above;

               (e) All licenses or other rights to use any of the Copyrights, Patents or Trademarks, and all
license fees and royalties arising from such use to the extent permitted by such license or rights;

 

 

               (f) All amendments, renewals and extensions of any of the Copyrights, Trademarks or Patents;
and

               (g) All proceeds of the foregoing, including without limitation all payments under insurance
or any indemnity or warranty payable in respect of any of the foregoing.

               As used herein, “Copyrights” means any and all copyright rights, copyright applications,
copyright registrations and like protections in each work or authorship and derivative work
thereof, whether published or unpublished and whether or not the same also constitutes a trade
secret, now or hereafter existing, created, acquired or held.

               As used herein, “Patents” means all patents, patent applications and like protections
including without limitation improvements, divisions, continuations, renewals, reissues, extensions
and continuations-in-part of the same.

               As used herein, “Trademarks” means any trademark and servicemark rights, whether registered or
not, applications to register and registrations of the same and like protections, and the entire
goodwill of the business of Borrower connected with and symbolized by such trademarks.

 

 

EXHIBIT B

TECHNOLOGY & LIFE SCIENCES DIVISION

LOAN ANALYSIS

LOAN ADVANCE/PAYDOWN REQUEST FORM

DEADLINE FOR SAME DAY PROCESSING IS [3:00* P.M., Pacific Time/ 3:30 P.M. Eastern Time]

FORMULA BASED LINES: DEADLINE FOR NEXT DAY PROCESSING IS [3:00* P.M., Pacific Time/ 3:30 P.M. Eastern Time]

DEADLINE FOR EQUIPMENT ADVANCES IS [3:00 P.M., Pacific Time/ 3:30 P.M. Eastern Time ]**

DEADLINE FOR WIRE TRANSFERS IS [1:30 P.M., Pacific Time/ 3:30 P.M. Eastern Time]

[*At month end and the day before a holiday, the cut off time is 1:30 P.M., Pacific Time]

**Subject to 3 day advance notice.

	 	 	 	 	 
	To: Loan Analysis

	 	 	 	DATE:                
           TIME:           
          
	FAX #: (650) 846-6840
	 	 	 	 

	 	 	 	 	 	 
	FROM:

	 	SANTARUS, INC.

	 	 	TELEPHONE REQUEST (For Bank Use Only):
	 

	 	Borrower’s Name

	 	 	 
	FROM:

	 	 

	 	 	The
following person is authorized to request the loan payment transfer/loan advance on the designated account and is known to me.
	

	 	 

Authorized Signer’s Name
	 	 
	 	 	 	 	 
	FROM:

	 	 	 	 	 
	 

	 	 
	 	 	 
	 

	 	Authorized Signer’s Name
	 	 	Authorized Request & Phone #
	 	 	 	 	 
	PHONE #:
	 	 	 	 	 
	 

	 	 
	 	 	 
	

	 	 	 	 	Received by (Bank) & Phone #
	 
	 	 	 	 	 
	FROM ACCOUNT#:
	 	 	 	 	 
	(please include Note number, if applicable)	 	 	 
	TO ACCOUNT #:

	 	 	Authorized Signature (Bank)
	(please include Note number, if applicable)	 	 	 

	 	 	 	 	 	 
	REQUESTED TRANSACTION TYPE
	REQUESTED DOLLAR AMOUNT	 	 	For Bank Use Only
	 
	 	 	 	 	 
	PRINCIPAL INCREASE* (ADVANCE)
	$	 	 	 	Date Rec’d:
	 
	 	 	 	 	 
	PRINCIPAL PAYMENT (ONLY)
	$	 	 	 	Time:
	 
	 	 	 	 	 
	 
	 	 	 	 	Comp. Status:          
 YES        NO
	OTHER INSTRUCTIONS:
	 	 	 	 	Status Date:
	 
	 	 	 	 	Time:
	 	 	 	 
	 
	 	 	 	 	Approval:
	 	 	 	 
	 
	 	 	 	 	 

All representations and warranties (including any updates thereto pursuant to Section 3.2(b) of the
Loan Agreement) of Borrower stated in the Loan Agreement, are true, correct and complete in all
material respects as of the date of the request for and advance confirmed by this Borrowing
Certificate; provided, however, that those representations and warranties that expressly refer to
another date shall be true, correct and complete in all material respects as of such date.

*IS THERE A WIRE REQUEST TIED TO THIS LOAN ADVANCE? (PLEASE CIRCLE ONE       
YES           NO

          If YES, the Outgoing Wire Transfer Instructions must be completed below.

	 	 	 	 	 	 	 	 	 	 	 
	OUTGOING WIRE TRANSFER INSTRUCTIONS	 	 	   Fed Reference Number	 	 	 	 Bank Transfer Number	 
	         	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 	 	 

The items marked with an asterisk (*) are required to be completed.

	 	 	 	 	 	 
	 	 	 	 
	*Beneficiary Name
	 	 	 	 	 
	*Beneficiary Account Number
	 	 	 	 	 
	*Beneficiary Address
	 	 	 	 	 
	Currency Type

	 	 	US DOLLARS ONLY

	*ABA Routing Number (9 Digits)
	 	 	 	 	 
	*Receiving Institution Name
	 	 	 	 	 
	*Receiving Institution Address
	 	 	 	 	 
	*Wire Account

	 	 	$	 	 

 

 

EXHIBIT C

BORROWING BASE CERTIFICATE

	 	 	 
	Borrower: SANTARUS, INC.

	 	Lender: Comerica Bank
	 
	 	 
	Commitment Amount: $25,000,000
	 	 

	 	 	 	 	 	 	 	 	 
	ACCOUNTS RECEIVABLE
	 	 	 	 	 	 	 	 
	1. Accounts Receivable Book Value as of ___
	 	 	 	 	 	$	                    	 
	2. Additions (please explain on reverse)
	 	 	 	 	 	$	                    	 
	3. TOTAL ACCOUNTS RECEIVABLE
	 	 	 	 	 	$	                    	 
	 
	 	 	 	 	 	 	 	 
	ACCOUNTS RECEIVABLE DEDUCTIONS (without duplication)
	 	 	 	 	 	 	 	 
	4. Amounts over 60 days past due
	 	$	                    	 	 	 	 	 
	5. Balance of 25% over 60 day past due accounts
	 	$	                    	 	 	 	 	 
	6. Concentration Limits
	 	 	 	 	 	 	 	 
	7. Foreign Accounts (other than Eligible Foreign
Accounts)
	 	$	                    	 	 	 	 	 
	8. Governmental Accounts
	 	$	                    	 	 	 	 	 
	9. Contra Accounts
	 	$	                    	 	 	 	 	 
	10. Demo Accounts
	 	$	                    	 	 	 	 	 
	11. Intercompany/Employee Accounts
	 	$	                    	 	 	 	 	 
	12. Other (please explain on reverse)
	 	$	                    	 	 	 	 	 
	13. TOTAL ACCOUNTS RECEIVABLE DEDUCTIONS
	 	 	 	 	 	$	                    	 
	14. Eligible Accounts (#3 minus #13)
	 	 	 	 	 	$	                    	 
	15. LOAN VALUE OF ACCOUNTS (80% of #14)
	 	 	 	 	 	$	                    	 

The undersigned represents and warrants that the foregoing is true, complete and correct, and that
the information reflected in this Borrowing Base Certificate complies with the representations and
warranties set forth in the Amended and Restated Loan and Security Agreement (including any updates
thereto pursuant to Section 3.2(b) of the Loan Agreement) between the undersigned and Comerica
Bank.

	 	 	 	 	 
	SANTARUS, INC.	 	 
	 
	 	 	 	 
	By: 
	 	 	 	 
	 

	 

Authorized Signer
	 	 

 

 

EXHIBIT D

COMPLIANCE CERTIFICATE

	 	 	 
	TO:

	 	COMERICA BANK
	 
	 	 
	FROM:

	 	SANTARUS, INC.

     The undersigned authorized officer of SANTARUS, INC. hereby certifies that in accordance with
the terms and conditions of the Amended and Restated Loan and Security Agreement between Borrower
and Bank (the “Agreement”), (i) Borrower is in complete compliance for the period ending
                     with all required covenants except as noted below and (ii) all representations and
warranties (including any updates thereto pursuant to Section 3.2(b) of the Loan Agreement) of
Borrower stated in the Agreement, as amended from time to time, are true and correct as of the date
hereof; provided, however, that those representations and warranties that expressly refer to
another date shall be true and correct in all material respects as of such date. Attached herewith
are the required documents supporting the above certification. The Officer further certifies that
these are prepared in accordance with Generally Accepted Accounting Principles (GAAP) and are
consistently applied from one period to the next except as explained in an accompanying letter or
footnotes.

Please indicate compliance status by circling Yes/No under “Complies” column.

	 	 	 	 	 	 	 
	Reporting Covenant	 	Required	 	Complies
	 
	Monthly financial statements

	 	Monthly within 40 days; except for
December: 30 days for drafts; 75 days
for final (when Liquidity includes
Eligible Accounts)
	 	Yes
	 	No
 N/A
	Quarterly financial statements (other than 4th 

quarter)

	 	Quarterly within 40 days (when
Liquidity does not include Eligible
Accounts)
	 	Yes
	 	No
 N/A
	Annual (CPA Audited)

	 	FYE within 120 days
	 	Yes
	 	No
 N/A
	10K and 10Q

	 	When filed
	 	Yes
	 	No
 N/A
	A/R & A/P Agings, Borrowing Base Cert.

	 	Monthly within 40 days (waived when
Liquidity does not include the
Borrowing Base)
	 	Yes
	 	No
 N/A
	Compliance Cert.

	 	Monthly within 40 days; except for
December: 30 days for drafts; 75 days
for final (when Liquidity includes
Eligible Accounts); otherwise quarterly
within 40 days
	 	Yes
	 	No
	A/R Audit

	 	Initial and Semi-Annual	 	 	 	 
	Total amount of Borrower’s cash and investments

	 	Amount: $                    	 	 	 	 
	Total amount of Borrower’s cash and investments
maintained with Bank and Bank’s Affiliates

	 	Amount: $4,000,000
	 	Yes
	 	No

	 	 	 	 	 	 	 	 	 
	Financial Covenant	 	Required	 	Actual	 	Complies
	Maintain at all times, measured Monthly (except as
indicated):
	 	 	 	 	 	 	 	 
	Minimum Cash
	 	$4,000,0001	 	$                    	 	Yes	 	No
	Minimum Liquidity (please explain
below)2
	 	1.25:1.003	 	_____:1.00	 	Yes	 	No
	Minimum EBITDA
	 	4	 	$                    	 	Yes	 	No

 

			
	1	 	Or 110% of Advances when Advances exceed $20,000,000 prior to an audit of the Collateral
(the results of which shall be satisfactory to Bank)
	 
	2	 	See Section 6.7(b) and explain on attachment RMC and Minimum Cash Component and Maximum Borrowing Base
Component
	 
	3	 	Or 1.10 to 1.00 when only Cash held at Bank and Bank’s Affiliates is used in the
calculation of Liquidity, which calculation shall be required when Advances exceed $20,000,000 prior to an audit of the
Collateral (the results of which shall be satisfactory to Bank)
	 
	4	 	measured, only when Advances are made against the Borrowing Base, quarterly on a trailing 6-month basis, as
set forth in Annex II to the Amended and Restated Loan and Security Agreement; to be reset for each of fiscal years 2008,
2009, 2010 and 2011 based on Borrower’s Board of Director’s approved budget for each year, to be delivered to Bank no later
than 12/31 of each year.

 

 

Comments Regarding Exceptions: See Attached.

Sincerely,

	 	 	 
	 

	 	 
	 
	 	 
	                    
	 	 
	 
	 	 
	 

	 	SIGNATURE
	 
	 	 
	 

	 	 
	 
	 	 
	                    
	 	 
	 
	 	 
	 

	 	TITLE
	 
	 	 
	 

	 	 
	 
	 	 
	                    
	 	 
	 
	 	 
	 

	 	DATE

	 	 	 
	BANK USE ONLY
	 
	 	 
	Received by:
	 	 
	 
	 
	 
	 	 
	                    
	 	 
	 
	 	 
	 
	 	AUTHORIZED SIGNER
	 
	 	 
	Date:
	 	 
	 
	 
	 
	 	 
	                    
	 	 
	 
	 	 
	Verified:
	 	 
	 
	 
	 
	 	 
	                    
	 	 
	 
	 	 
	 
	 	AUTHORIZED SIGNER
	 
	 	 
	Date:
	 	 
	 
	 
	 
	 	 
	             
       
	 	 
	 
	 	 
	Compliance Status
	 	Yes        Noexv10w2

Exhibit 10.2

Amended and Restated LIBOR Addendum

to Amended and Restated Loan and Security Agreement

     This Amended and Restated LIBOR Addendum to Amended and Restated Loan and Security Agreement
(this “Addendum”) is entered into as of July 11, 2008, by and between COMERICA BANK (“Bank”) and
SANTARUS, INC. (“Borrower”). This Addendum supplements the terms of the Amended and Restated Loan
and Security Agreement (the “Loan Agreement”) of even date herewith.

      1. Definitions.

          (a) Advance. As used herein, “Advance” means a borrowing requested by Borrower and
made by Bank under the Loan Agreement, including a LIBOR Option Advance and/or a Prime Rate Option
Advance (as hereafter defined).

          (b) Business Day. As used herein, “Business Day” means any day that is not a
Saturday, Sunday, or other day on which banks in the State of California are authorized or required
to close.

          (c) LIBOR. As used herein, “LIBOR” means the rate per annum (rounded upward if
necessary, to the nearest whole 1/8 of 1%) and determined pursuant to the following formula:

	 	 	 	 	 	 	 
	 

	 	 LIBOR =
	 	Base LIBOR	 	 
	 

	 	 	 	 

100% — LIBOR Reserve Percentage
	 	 

               (1) “Base LIBOR” means the rate per annum determined by Bank at which deposits for the
relevant LIBOR Period would be offered to Bank in the approximate amount of the relevant LIBOR
Option Advance in the interbank LIBOR market selected by Bank, upon request of Bank at 10:00 a.m.
California time, on the day that is the first day of such LIBOR Period.

               (2) “LIBOR Reserve Percentage” means the reserve percentage prescribed by the Board of
Governors of the Federal Reserve System (or any successor) for “Eurocurrency Liabilities” (as
defined in Regulation D of the Federal Reserve Board, as amended), adjusted by Bank for expected
changes in such reserve percentage during the applicable LIBOR Period.

          (d) LIBOR Business Day. As used herein, “LIBOR Business Day” means a Business Day on
which dealings in Dollar deposits may be carried out in the interbank LIBOR market.

          (e) LIBOR Period. As used herein, “LIBOR Period” means, with respect to a LIBOR
Option Advance:

               (1) initially, the period commencing on, as the case may be, the date the Advance is made or
the date on which the Advance is converted to a LIBOR Option Advance, and continuing for, in every
case, a 30-, 60-, or 90-day period thereafter so long as the LIBOR Option is quoted for such period
in the applicable interbank LIBOR market, as such period is selected by Borrower in the Loan
Advance/Paydown Request Form as provided in the Loan Agreement or in the Prime Rate/Libor Rate
Advance Request Form as provided in this Addendum; and

               (2) thereafter, each period commencing on the last day of the next preceding LIBOR Period
applicable to such LIBOR Option Advance and continuing for, in every case, a 30-, 60-, or 90-day
period thereafter so long as the LIBOR Option is quoted for such period in the applicable interbank
LIBOR market, as such period is selected by Borrower in the Prime Rate/Libor Rate Advance Request
Form as provided in this Addendum.

          (f) Regulation D. As used herein, “Regulation D” means Regulation D of the Board of
Governors of the Federal Reserve System as amended or supplemented from time to time.

          (g) Regulatory Development. As used herein, “Regulatory Development” means any or all
of the following: (i) any change in any law, regulation or interpretation thereof by any public
authority (whether or not having

-1-

 

the force of law); (ii) the application of any existing law, regulation or the interpretation
thereof by any public authority (whether or not having the force of law); and (iii) compliance by
Bank with any request or directive (whether or not having the force of law) of any public
authority.

     2. Interest Rate Options. Borrower shall have the following options regarding the
interest rate to be paid by Borrower on Advances under the Loan Agreement:

          (a) A rate equal to three percent (3.00%) above Bank’s LIBOR, (the “LIBOR Option”), which
LIBOR Option shall be in effect during the relevant LIBOR Period; or

          (b) A rate equal to one half of one percent (0.50%) above the Prime Rate as defined in the
Loan Agreement and quoted from time to time by Bank as such rate may change from time to time (the
“Prime Rate Option”).

     3. LIBOR Option Advance. The minimum LIBOR Option Advance will not be less than Five
Hundred Thousand Dollars ($500,000) for any LIBOR Option Advance.

     4. Payment of Interest on LIBOR Option Advances. Interest on each LIBOR Option
Advance shall be payable pursuant to the terms of the Loan Agreement. Interest on such LIBOR
Option Advance shall be computed on the basis of a 360-day year and shall be assessed for the
actual number of days elapsed from the first day of the LIBOR Period applicable thereto but not
including the last day thereof.

     5. Bank’s Records Re: LIBOR Option Advances. With respect to each LIBOR Option
Advance, Bank is hereby authorized to note the date, principal amount, interest rate and LIBOR
Period applicable thereto and any payments made thereon on Bank’s books and records (either
manually or by electronic entry) and/or on any schedule attached to the Loan Agreement, which
notations shall be prima facie evidence of the accuracy of the information so noted.

     6. Selection/Conversion of Interest Rate Options. At the time any Advance is
requested under the Loan Agreement and/or Borrower wishes to select the LIBOR Option for all or a
portion of the outstanding principal balance of the Loan Agreement, and at the end of each LIBOR
Period, Borrower shall give Bank notice specifying (a) the interest rate option selected by
Borrower; b) the principal amount subject thereto; and (c) if the LIBOR Option is selected, the
length of the applicable LIBOR Period. Any such notice may be given by email so long as, with
respect to each LIBOR Option selected by Borrower, (i) Bank receives written confirmation from
Borrower not later than three (3) LIBOR Business Days after such email notice is given; and (ii)
such notice is given to Bank prior to 10:00 a.m., California time, on the first day of the LIBOR
Period. For each LIBOR Option requested hereunder, Bank will quote the applicable fixed LIBOR Rate
to Borrower at approximately 10:00 a.m., California time, on the first day of the LIBOR Period. If
Borrower does not immediately accept the rate quoted by Bank, any subsequent acceptance by Borrower
shall be subject to a redetermination of the rate by Bank; provided, however, that if Borrower
fails to accept any such quotation given, then the quoted rate shall expire and Bank shall have no
obligation to permit a LIBOR Option to be selected on such day. If no specific designation of
interest is made at the time any Advance is requested under the Loan Agreement or at the end of any
LIBOR Period, Borrower shall be deemed to have selected the Prime Rate Option for such Advance or
the principal amount to which such LIBOR Period applied. At any time the LIBOR Option is in
effect, Borrower may, at the end of the applicable LIBOR Period, convert to the Prime Rate Option.
At any time the Prime Rate Option is in effect, Borrower may convert to the LIBOR Option, and shall
designate a LIBOR Period.

     7. Default Interest Rate. From and after the maturity date of the Loan Agreement, or
such earlier date as all principal owing hereunder becomes due and payable by acceleration or
otherwise, the outstanding principal balance of the Loan Agreement shall bear interest until paid
in full at an increased rate per annum (computed on the basis of a 360-day year, actual days
elapsed) equal to three percent (3.00%) above the rate then in effect.

     8. Prepayment. In the event that the LIBOR Option is the applicable interest rate for
all or any part of the outstanding principal balance of the Loan Agreement, and any payment or
prepayment of any such outstanding principal balance of the Loan Agreement shall occur on any day
other than the last day of the applicable LIBOR Period (whether voluntarily, by acceleration,
required payment, or otherwise), or if Borrower elects the LIBOR Option as the applicable interest
rate for all or any part of the outstanding principal balance of the Loan Agreement in accordance
with the terms

-2-

 

and conditions hereof, and, subsequent to such election, but prior to the commencement of the
applicable LIBOR Period, Borrower revokes such election for any reason whatsoever, or if the
applicable interest rate in respect of any outstanding principal balance of the Loan Agreement
hereunder shall be changed, for any reason whatsoever, from the LIBOR Option to the Prime Rate
Option prior to the last day of the applicable LIBOR Period, or if Borrower shall fail to make any
payment of principal or interest hereunder at any time that the LIBOR Option is the applicable
interest rate hereunder in respect of such outstanding principal balance of the Loan Agreement,
Borrower shall reimburse Bank, on demand, for any resulting loss, cost or expense incurred by Bank
as a result thereof, including, without limitation, any such loss, cost or expense incurred in
obtaining, liquidating, employing or redeploying deposits from third parties. Such amount payable
by Borrower to Bank may include, without limitation, an amount equal to the excess, if any, of (a)
the amount of interest which would have accrued on the amount so prepaid, or not so borrowed,
refunded or converted, for the period from the date of such prepayment or of such failure to
borrow, refund or convert, through the last day of the relevant LIBOR Period, at the applicable
rate of interest for such outstanding principal balance of the Loan Agreement, as provided under
this Loan Agreement, over (b) the amount of interest (as reasonably determined by Bank) which would
have accrued to Bank on such amount by placing such amount on deposit for a comparable period with
leading banks in the interbank LIBOR market. Calculation of any amounts payable to Bank under this
paragraph shall be made as though Bank shall have actually funded or committed to fund the relevant
outstanding principal balance of the Loan Agreement hereunder through the purchase of an underlying
deposit in an amount equal to the amount of such outstanding principal balance of the Loan
Agreement and having a maturity comparable to the relevant LIBOR Period; provided, however, that
Bank may fund the outstanding principal balance of the Loan Agreement hereunder in any manner it
deems fit and the foregoing assumptions shall be utilized only for the purpose of the calculation
of amounts payable under this paragraph. Upon the written request of Borrower, Bank shall deliver
to Borrower a certificate setting forth the basis for determining such losses, costs and expenses,
which certificate shall be conclusively presumed correct, absent manifest error. Any prepayment
hereunder shall also be accompanied by the payment of all accrued and unpaid interest on the amount
so prepaid. Any outstanding principal balance of the Loan Agreement which is bearing interest at
such time at the Prime Rate Option may be prepaid without penalty or premium. Partial prepayments
hereunder shall be applied to the installments hereunder in the inverse order of their maturities.

     BY INITIALING BELOW, BORROWER ACKNOWLEDGE(S) AND AGREE(S) THAT: (A) THERE IS NO RIGHT TO
PREPAY ANY LIBOR OPTION ADVANCE , IN WHOLE OR IN PART, WITHOUT PAYING THE PREPAYMENT AMOUNT, EXCEPT
AS OTHERWISE REQUIRED UNDER APPLICABLE LAW; (B) BORROWER SHALL BE LIABLE FOR PAYMENT OF THE
PREPAYMENT AMOUNT IF BANK EXERCISES ITS RIGHT TO ACCELERATE PAYMENT OF ANY LIBOR OPTION ADVANCE AS
PART OR ALL OF THE OBLIGATIONS OWING UNDER THE LOAN AGREEMENT, INCLUDING WITHOUT LIMITATION,
ACCELERATION UNDER A DUE-ON-SALE PROVISION; (C) BORROWER WAIVE ANY RIGHTS UNDER SECTION 2954.10 OF
THE CALIFORNIA CIVIL CODE, OR ANY SUCCESSOR STATUTE; AND (D) BANK HAS MADE EACH LIBOR OPTION
ADVANCE PURSUANT TO THE LOAN AGREEMENT IN RELIANCE ON THESE AGREEMENTS.

	 	 	 
	/s/ dpc
	 	 
	 

	 	 

     BORROWER’S INITIALS

     9. Hold Harmless and Indemnification. Borrower agrees to indemnify Bank and to hold
Bank harmless from, and to reimburse Bank on demand for, all losses and expenses which Bank
sustains or incurs as a result of (i) any payment of a LIBOR Option Advance prior to the last day
of the applicable LIBOR Period for any reason, including, without limitation, termination of the
Loan Agreement, whether pursuant to this Addendum or the occurrence of an Event of Default; (ii)
any termination of a LIBOR Period prior to the date it would otherwise end in accordance with this
Addendum; or (iii) any failure by any Borrower, for any reason, to borrow any portion of a LIBOR
Option Advance.

     10. Funding Losses. The indemnification and hold harmless provisions set forth in
this Addendum shall include, without limitation, all losses and expenses arising from interest and
fees that Bank pays to lenders of funds it obtains in order to fund the loans to Borrower on the
basis of the LIBOR Option(s) and all losses incurred in liquidating or re-deploying deposits from
which such funds were obtained and loss of profit for the period after termination. A written
statement by Bank to Borrower of such losses and expenses shall be conclusive and binding, absent
manifest

-3-

 

error, for all purposes. This obligation shall survive the termination of this Addendum and
the payment of the Loan Agreement.

     11. Regulatory Developments Or Other Circumstances Relating To Illegality or
Impracticality of LIBOR. If any Regulatory Development or other circumstances relating to the
interbank Euro-dollar markets shall, at any time, in Bank’s reasonable determination, make it
unlawful or impractical for Bank to fund or maintain, during any LIBOR Period, to determine or
charge interest rates based upon LIBOR, Bank shall give notice of such circumstances to Borrower
and:

          (i) In the case of a LIBOR Period in progress, Borrower shall, if requested by Bank, promptly
pay any interest which had accrued prior to such request and the date of such request shall be
deemed to be the last day of the term of the LIBOR Period; and

          (ii) No LIBOR Period may be designated thereafter until Bank determines that such would be
practical.

     12. Additional Costs. Borrower shall pay to Bank from time to time, upon Bank’s
request, such amounts as Bank reasonably determines are needed to compensate Bank for any costs it
incurred which are attributable to Bank having made or maintained a LIBOR Option Advance or to
Bank’s obligation to make a LIBOR Option Advance, or any reduction in any amount receivable by Bank
hereunder with respect to any LIBOR Option or such obligation (such increases in costs and
reductions in amounts receivable being herein called “Additional Costs”), to the extent resulting
from any Regulatory Developments, which (i) change the basis of taxation of any amounts payable to
Bank hereunder with respect to taxation of any amounts payable to Bank hereunder with respect to
any LIBOR Option Advance (other than taxes imposed on the overall net income of Bank for any LIBOR
Option Advance by the jurisdiction where Bank is headquartered or the jurisdiction where Bank
extends the LIBOR Option Advance; (ii) impose or modify any reserve, special deposit, or similar
requirements relating to any extensions of credit or other assets of, or any deposits with or other
liabilities of, Bank (including any LIBOR Option Advance or any deposits referred to in the
definition of LIBOR); or (iii) impose any other condition affecting this Addendum (or any of such
extension of credit or liabilities). Bank shall notify Borrower of any event occurring after the
date hereof which entitles Bank to compensation pursuant to this paragraph as promptly as
practicable after it obtains knowledge thereof and determines to request such compensation.
Determinations by Bank for purposes of this paragraph, shall be conclusive, provided that such
determinations are made on a reasonable basis.

     13. Legal Effect. Except as specifically modified hereby, all of the terms and
conditions of the Loan Agreement remain in full force and effect. This Addendum completely amends
and restates that certain LIBOR Addendum to Loan and Security Agreement among Bank and Borrowers
dated as of July 28, 2006.

[Balance of Page Intentionally Left Blank]

-4-

 

     IN WITNESS WHEREOF, the parties have agreed to the foregoing as of the date first set forth above.

	 	 	 	 	 
	 	 	SANTARUS, INC.
	 
	 	 	 	 
	 

	 	By: 
	/s/ Debra P. Crawford
	 

	 	 	 
	 
	 	 	 	 
	 

	 	Title: 
	SVP & CFO
	 
	 	 	 	 
	 	 	COMERICA BANK
	 
	 	 	 	 
	 

	 	By: 
	/s/ Steven J. Stuckey
	 

	 	 	 
	 
	 	 	 	 
	 

	 	Title:
	Senior Vice President

[Signature Page to Amended and Restated LIBOR Addendum

to Amended and Restated Loan and Security Agreement]

 

 

PRIME RATE/LIBOR RATE ADVANCE REQUEST FORM

     The undersigned hereby certifies as follows:

     I,                                                             , am the duly
elected and acting                                          of
SANTARUS, INC. (“Borrower”).

     This Prime Rate/LIBOR Rate Advance Request Form is delivered on behalf of Borrower to Comerica
Bank, pursuant to that certain Amended and Restated Loan and Security Agreement among Borrower and
Comerica Bank, dated as of July 11, 2008 (the “Agreement”). The terms used herein which are
defined in the Agreement have the same meaning herein as ascribed to them therein.

     Borrower hereby request on                                         , 20___, an Advance/conversion from one rate to
another, as follows:

     (a) The date on which the Advance is to be made/converted is                     , 20___.

     (b) The amount of the Advance/conversion is to be                                          ($                  
  ), in the
form of a Prime Rate Advance of $                                        ; and/or a LIBOR Rate Advance of
$                                         for a LIBOR Interest Period of                      days.

     All representations and warranties (including any updates thereto in accordance with Section
3.2(b) of the Agreement) of Borrower stated in the Agreement (as amended from time to time) are
true, correct and complete in all material respects as of the date of this Request; provided,
however, that those representations and warranties expressly referring to another date shall be
true, correct and complete in all material respects as of such date.

     IN WITNESS WHEREOF, this Prime Rate/LIBOR Rate Advance Request Form is executed by the
undersigned as of this                      day of                     , 20___.

	 	 	 	 	 
	 	 	SANTARUS, INC.
	 
	 	 	 	 
	 

	 	By: 	 	 
	 

	 	 	 
	 
	 	 	 	 
	 

	 	Title:

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