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Exhibit 10.57    
    

	 	 	Millennium Pharmaceuticals, Inc.

640 Memorial Drive

Cambridge, MA 02139

Tel 617 679 7000

mlnm.com

        [Millennium
logo] 

February 28,
2001 

Peter
F. Smith, Ph.D.

6755 Foxworth Lane

Gurnee, IL 60031 

Dear
Peter, 

        On
behalf of Millennium Pharmaceuticals, Inc. (the "Company"), I am pleased to offer you the position of Senior Vice President, Pre-Clinical Development reporting to
Mark Levin, Acting President, Research and Development. 

        1.    Effective Date:    The effective date of your full-time employment with the Company is to be
determined upon your formal acceptance of this offer. After discussion with the hiring manager, please contact Shana Stevens at 617-551-7889 to confirm your start date. 

        2.    Salary:    Your base salary will initially be $265,000 per annum. Your salary will be paid periodically in
accordance with the Company's payroll procedures. In addition, in accordance with the Company's compensation practices, you will receive, approximately annually, a salary review which will be based on
your performance, the Company's performance and such other factors as may be determined by the Company's Board of Directors. 

        3.    Success Sharing:    You will be eligible to participate in the Millennium Success Sharing cash bonus program,
which includes a fixed percentage of salary target for each position, prorated for length of active service in the calendar year. The funding of the target is based on the Company meeting overall
goals established at the beginning of each calendar year. In the event of Company performance below or above target, your personal bonus target may vary. Your individual bonus payment will also vary
based on your individual performance. The target for your position is 25% of your annual salary. Your manager will work with you to establish your individual goals, which will be the primary factor in
determining your bonus payment. Bonus payments will be made to eligible and active employees in March of 2002 for the 2001 Success Sharing Plan. 

        4.    Benefits:    You and your dependents will be eligible for the Company's standard medical, dental, life
insurance, disability benefits and Section 125 cafeteria plan. After the standard waiting periods, you will also be eligible to participate in the Company's 401(k) and Employee Stock Purchase
plans. You will accrue vacation at the rate of 1.25 days per month of full-time employment. Standard paid holidays will be observed. Transportation benefits, including a choice of
MBTA pass up to $60 or contributory off-site parking, are also available. The Company, however, reserves the right to modify its employee benefit programs from
time-to-time. 

        5.    Equity Participation, Vesting of Stock:    Subject to approval by the Company's Board of Directors, you will be
granted stock options exercisable for 120,000 shares of the Company's Common Stock. One third (1/3) of the total number of stock options will be granted on the last day of the calendar
month in which you commence full-time employment with the Company, and one third will be 

 

granted
on the last day of each of the next two succeeding calendar months. The exercise price of these stock options will be equal to the fair market value of Millennium's Common Stock on the date of
each grant. All options will vest as to one fourth (1/4) of the shares on the first anniversary of your commencement of full-time employment with the Company and as to one
forty-eighth (1/48) of the shares monthly thereafter until all shares are vested, provided that you remain employed by the Company. In the event of your death, all options will vest
immediately as to all shares. In the event of termination of your employment for any reason (except as set forth in the preceding sentence), vesting as to all shares shall cease. Provided that you
remain employed by the Company, these stock options will be exercisable (as to the vested portion) for 10 years from the date of each grant. A complete description of the terms and conditions
of these stock options are contained in the Company's 2000 Stock Incentive Plan or will be contained in your stock option grant forms. 

        6.    Employment Period:    Your employment with the Company will be at-will, meaning that you will not be
obligated to remain employed by the Company for any specified period of time; likewise, the Company will not be obligated to continue your employment for any specific period and may terminate your
employment at any time, with or without cause. 

        7.    Employment Eligibility Verification:    Please note that all persons employed in the United States, are required
to complete an Employment Eligibility Verification Form on the first day of employment and submit an original document or documents that establish identity and employment eligibility within three
business days of employment. For your convenience, we are enclosing Form I-9 for your review. You will need to complete Section 1 and present original document(s) of your
choice as listed on the reverse side of the form once you begin work. Please note: the I-9 form and valid identification are legal  requirements and must be submitted
within 3 days of your start date. If you do not submit the required documentation
within the 3-day time frame, by law we cannot allow you to continue to work.

        8.    Proprietary Information, No Conflicts:    You agree to execute the Company's standard form of Invention,
Non-Disclosure and Non-Competition Agreement and to be bound by all of the provisions thereof. You hereby represent that you are not presently bound by any employment
agreement, confidential or proprietary information agreement or similar agreement with any current or previous employer that would impose any restriction on your acceptance of this offer or that would
interfere with your ability to fulfill the responsibilities of your position with the Company. 

        9.    Medical Surveillance:    As part of Millennium's medical surveillance program, employees are required to have an
initial physical, provided by an on-site registered nurse. All laboratory employees working with hazardous chemical, infectious agents, radio labeled materials or animals shall have access
to medical attention, including initial and periodic medical exams without cost to the employee or loss of pay. An employee may refuse an exam if he/she signs a release. If you want to decline from
having the initial physical, please notify Human Resources on your first day at New Employee Orientation. Your initial surveillance examination will be scheduled to take place during the first week of
your employment. 

        10.    New Employee Orientation:    On the first Monday of your employment with the Company, you should arrive at our
75 Sidney Street at location for New Employee Orientation. Millennium is located at University Park at 75 Sidney Street, and orientation is held on the 1st floor. If taking the MBTA you will
get off at the Central Square stop on the Red Line. Directions for driving are enclosed. Millennium will reimburse you for any parking expenses. Orientation will begin promptly at 8:30 a.m. 

        11.    Sign-on Bonus:    The Company will pay you a bonus of $50,000 on the date of the first paycheck
following commencement of your full time employment. Should you terminate for any reason within 12 months of your starting date after having received your bonus, the Company reserves the right
to seek repayment of all or a pro-rata portion of your bonus. 

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        12.    Loan:    The Company will loan you a total of $50,000, payable to you on the date of your first paycheck
following commencement of your full time employment. This loan (with interest), which will be forgivable over a two-year period, will be granted pursuant to the terms and conditions of a
loan agreement which will be forwarded to you under separate cover. One-half of the principal and interest will be forgiven on the one year anniversary of your full-time
employment with the Company, and one twenty-fourth (1/24) of the loan will be forgiven at the end of each full month thereafter until the entire loan has been forgiven, provided that
you remain employed by the Company. In the event of your termination from the Company, the principal balance and interest will be due. The loan will be secured by a second mortgage on your principal
residence. 

        13.    Severance:    In the event that your employment is terminated by the Company other than for Justifiable Cause
(as defined below, the Company will pay you a severance payment (the "Severance Payment") equal to 12 months' salary (no stock vesting). The Severance Payment will be payable periodically in
accordance with the Company's payroll procedures as then in effect and the Company's Obligation to make the Severance Payment will cease in the event that you accept other employment. In the event
your employment is terminated by the Company for Justifiable Cause (as defined below) or voluntarily by you, you will not be entitled to any Severance Payment. 

        For
purposes hereof, the term "Justifiable Cause" shall mean the occurrence of any of the following events: (I) your conviction of, or pleas of nolo contendere with respect to a
felony or a crime involving moral turpitude, (ii) your commission of an act of personal dishonesty or breach of fiduciary duty involving personal profit in connection with the Company,
(iii) your commission of an act, or failure to act, which the Board of Directors of the Company shall reasonably have found to have involved willful misconduct or gross negligence on your part,
in the conduct of your duties hereunder, (iv) habitual absenteeism, alcoholism or drug dependence on your part which interferes with the performance of your duties hereunder, (v) your
willful and material breach or refusal to perform your services as provided herein, (vi) any other material breach by you of the provisions hereof or (vii) your willful and material
failure or refusal to carry out a direct request of the Board of Directors of Chief Executive
Officer. In the event that the company terminates your employment for Justifiable Cause, the Company will provide you with a statement of the basis for such termination and an opportunity to respond
thereto. 

        14.    Relocation Expenses:    Upon your acceptance of this offer, you are eligible for reimbursement of the following
expenses associated with your relocation. Specific relocation information will follow from MSI, Millennium's relocation company.

	•
	Reimbursement
for expenses associated with direct-route transportation to Cambridge.

	•
	The
cost of packing, moving, 60 days' temporary storage, and unloading of your household goods and effects using a certified carrier of the Company's choice.

	•
	Temporary
housing for six months upon your arrival in the Boston area or $3,000 (grossed up) lump sum if housing is not used.

	•
	Destination
services provided by Corporate Real Estate Services, a division of Hunneman Coldwell Banker.

	•
	The
Company will provide a lump sum allowance of $5,000 (grossed up) to cover additional relocation related expenses. This sum will be paid to you by MSI once you submit a
request for payment. 

Should
you voluntarily resign from the Company within one year of relocating, the Company reserves the right to seek repayment of the entire amount. 

	•
	Two
house-hunting trips for up to eight (8) days for the purpose of locating suitable housing. 

3

 

	•
	Delivery
of car before final move date 

        Should
you voluntarily resign from the Company within one year of relocating, the Company reserves the right to seek repayment of all reimbursed relocation
expenses. 

        Peter,
all of us here at Millennium are very enthusiastic about you commitment to joining the Company and have the highest expectation of your future contributions. 

        Please
indicate your acceptance of the foregoing by signing the enclosed copy of this letter and returning it to Shani Stickney no later than March 8, 2001. After that date, the
offer will lapse. 

Very
truly yours,

MILLENNIUM PHARMACEUTICALS, INC. 

	/s/  LINDA K. PINE      
 Linda K. Pine

Sr. Vice President, Human Resources	 	 
	

The foregoing is signed and accepted as of the date first above written by:
	

/s/  PETER F. SMITH      
 Peter F. Smith, Ph.D.	
 	

3/5/01
 Date

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Exhibit 10.57QuickLinks
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Exhibit 10.58    
    

        Millennium Pharmaceuticals, Inc. has entered into an indemnification agreement on the terms set forth on the attached indemnification agreement with each
of the below-named executive officers and directors of Millennium, on the dates indicated: 

	Name of executive officer or director
 
	 	Date of Execution

	Deborah Dunsire	 	February 28, 2008
	

Marsha H. Fanucci	
 	

February 28, 2008
	

Christophe Bianchi	
 	

February 28, 2008
	

Joseph B. Bolen	
 	

February 28, 2008
	

Stephen M. Gansler	
 	

February 28, 2008
	

Laurie B. Keating	
 	

February 28, 2008
	

Anna Protopapas	
 	

February 28, 2008
	

Nancy Simonian	
 	

February 28, 2008
	

Peter F. Smith	
 	

February 28, 2008
	

Robert F. Friel	
 	

February 28, 2008
	

A. Grant Heidrich, III	
 	

February 28, 2008
	

Charles J. Homcy	
 	

February 28, 2008
	

Raju S. Kucherlapati	
 	

February 28, 2008
	

Jeffrey M. Leiden	
 	

February 28, 2008
	

Mark J. Levin	
 	

February 28, 2008
	

Norman C. Selby	
 	

February 28, 2008
	

Kenneth E. Weg	
 	

February 28, 2008
	

Anthony H. Wild	
 	

February 28, 2008

 

  INDEMNIFICATION AGREEMENT  

        This Agreement is made as of the                        day of
February 2008, by and between Millennium Pharmaceuticals, Inc., a Delaware corporation (the
"Corporation), and                                    (the
"Indemnitee"), a director or officer of the Corporation. 

        WHEREAS,
it is essential to the Corporation to retain and attract as directors and officers the most capable persons available, and 

        WHEREAS,
the substantial increase in corporate litigation subjects directors and officers to expensive litigation risks at the same time that the availability of directors' and officers'
liability insurance has been severely limited, and 

        WHEREAS,
it is now and has always been the express policy of the Corporation to indemnify its directors and officers, and 

        WHEREAS,
the Indemnitee does not regard the protection available under the Corporation's Certificate of Incorporation and insurance as adequate in the present circumstances, and may not
be willing to serve or continue to serve as a director or officer without adequate protection, and 

        WHEREAS,
the Corporation desires the Indemnitee to serve, or continue to serve, as a director or officer of the Corporation. 

        NOW
THEREFORE, the Corporation and the Indemnitee do hereby agree as follows: 

        1.    Agreement to Serve.    The Indemnitee agrees to serve or continue to serve as a director or officer of the
Corporation for so long as the Indemnitee is duly elected or appointed or until such time as the Indemnitee tenders a resignation in writing. 

        2.    Definitions.    As used in this Agreement: 

        (a)   The
term "Proceeding" shall include any threatened, pending or completed action, suit, arbitration, alternative dispute resolution proceeding, administrative hearing or
other proceeding, whether brought by or in the right of the Corporation or otherwise and whether of a civil, criminal, administrative or investigative nature, and any appeal therefrom. 

        (b)   The
term "Board" means the Board of Directors of the Corporation. 

        (c)   The
term "Change in Control" shall mean the occurrence of any of the below events: 

          (i)  when
a person, entity or group (within the meaning of Section 13(d)(3) or 14(d)(2) of the Securities Exchange Act of 1934, as amended) acquires beneficial
ownership of the Corporation's capital stock equal to 50% or more of either (x) the then-outstanding shares of the Corporation's common stock or (y) the combined voting power
of the Corporation's then-outstanding securities entitled to vote generally in the election of directors; 

         (ii)  upon
the consummation of (x) a merger, consolidation, reorganization, recapitalization or share exchange involving the Corporation or a sale or other disposition
of all or substantially all of the assets of the Corporation, if the Corporation's stockholders immediately prior to such event do not, immediately after such event, own more than 50% of the
outstanding shares of common stock and of the combined voting power entitled to vote generally in the election of directors of the resulting or acquiring corporation (which shall include, without
limitation, a corporation which as a result of such event owns the Corporation or substantially all of the Corporation's assets either directly of through one or more subsidiaries), in substantially
the same proportions as their ownership of the Corporation's voting securities immediately prior to such event, or (y) a liquidation or dissolution of the Corporation; or 

2

 

        (iii)  when
the Continuing Directors (as defined below) do not constitute a majority of the Board (or, if applicable, the board of directors of a successor corporation to the
Corporation), where the term "Continuing Director" means at any date a member of the Board (x) who was a member of the Board on the date this agreement was entered into or (y) who was
nominated or elected subsequent to such date by at least a majority of the directors who were Continuing Directors at the time of such nomination or election or whose election to the Board was
recommended or endorsed by at least a
majority of the directors who were Continuing Directors at the time of such nomination or election. But, any individual whose initial assumption of office occurred as a result of an actual or
threatened election contest with respect to the election or removal of directors or other actual or threatened solicitation of proxies or consents, by or on behalf of a person other than the Board, is
excluded from clause (iii)(y) above 

        (d)   The
term "Corporate Status" shall mean the status of a person who is or was, or has agreed to become, a director or officer of the Corporation, or is or was serving, or
has agreed to serve, at the request of the Corporation, as a director, officer, fiduciary, partner, trustee, member, employee or agent of, or in a similar capacity with, another corporation,
partnership, joint venture, trust, limited liability company or other enterprise. 

        (e)   The
term "Special Independent Counsel" shall mean a law firm, or a member of a law firm, that is experienced in matters of corporation law and neither currently is, nor
in the past five years has been, retained to represent: (i) the Corporation or the Indemnitee in any matter material to either such party or (ii) any other party to the Proceeding giving
rise to a claim for indemnification hereunder. Notwithstanding the foregoing, the term "Special Independent Counsel" shall not include any person who, under the applicable standards of professional
conduct then prevailing, would have a conflict of interest in representing either the Corporation or the Indemnitee in an action to determine the Indemnitee's rights under this Agreement. 

        (f)    The
term "Expenses" shall include, without limitation, reasonable and necessary attorneys' fees, retainers, court costs, transcript costs, fees and expenses of experts,
travel expenses, duplicating costs, printing and binding costs, telephone charges, postage, delivery service fees and other disbursements or expenses of the types customarily incurred in connection
with investigations, judicial or administrative proceedings or appeals, but shall not include the amount of judgments, fines or penalties against Indemnitee or amounts paid in settlement in connection
with such matters. 

        (g)   References
to "other enterprise" shall include employee benefit plans; references to "fines" shall include any excise tax assessed with respect to any employee benefit
plan; references to "serving at the request of the Corporation" shall include any service as a director, officer, employee or agent of the Corporation which imposes duties on, or involves services by,
such director, officer, employee, or agent with respect to an employee benefit plan, its participants, or beneficiaries; and a person who acted in good faith and in a manner such person reasonably
believed to be in the interests of the participants and beneficiaries of an employee benefit plan shall be deemed to have acted in a manner "not opposed to the best interests of the Corporation" as
referred to in this Agreement. 

        3.    Indemnity of Indemnitee.    Subject to Sections 6, 7 and 9, the Corporation shall indemnify the
Indemnitee in connection with any Proceeding as to which the Indemnitee is, was or is threatened to be made a party (or is otherwise involved) by reason of the Indemnitee's Corporate Status, to the
fullest extent permitted by law (as such may be amended from time to time). In furtherance of the foregoing and without limiting the generality thereof: 

        (a)    Indemnification in Third-Party Proceedings.    The Corporation shall indemnify the Indemnitee in accordance
with the provisions of this Section 3(a) if the Indemnitee was or is a 

3

 

party
to or threatened to be made a party to or otherwise involved in any Proceeding (other than a Proceeding by or in the right of the Corporation to procure a judgment in its favor or a Proceeding
referred to in Section 6) by reason of the Indemnitee's Corporate Status or by reason of any action alleged to have been taken or omitted in connection therewith, against all Expenses,
judgments, fines, penalties and amounts paid in settlement actually and reasonably incurred by or on behalf of the Indemnitee in connection with such Proceeding, if the Indemnitee acted in good faith
and in a manner which the Indemnitee reasonably believed to be in, or not opposed to, the best interests of the Corporation and, with respect to any criminal Proceeding, had no reasonable cause to
believe that his or her conduct was unlawful. 

        (b)    Indemnification in Proceedings by or in the Right of the Corporation.    The Corporation shall indemnify the
Indemnitee in accordance with the provisions of this Section 3(b) if the Indemnitee was or is a party to or threatened to be made a party to or otherwise involved in any Proceeding by or in the
right of the Corporation to procure a judgment in its favor by reason of the Indemnitee's Corporate Status or by reason of any action alleged to have been taken or omitted in connection therewith,
against all Expenses and, to the extent permitted by law, amounts paid in settlement actually and reasonably incurred by or on behalf of the Indemnitee in connection with such Proceeding, if the
Indemnitee acted in good faith and in a manner which the Indemnitee reasonably believed to be in, or not opposed to, the best interests of the Corporation, except that, if applicable law so provides,
no indemnification shall be made under this Section 3(b) in respect of any claim, issue, or matter as to which the Indemnitee shall have been adjudged to be liable to the Corporation, unless,
and only to the extent, that the Court of Chancery of Delaware or the court in which such action or suit was brought shall determine upon application that, despite the adjudication of such liability
but in view of all the circumstances of the case, the Indemnitee is fairly and reasonably entitled to indemnity for such Expenses as the Court of Chancery or such other court shall deem proper. 

        4.    Indemnification of Expenses of Successful Party.    Notwithstanding any other provision of this Agreement, to
the extent that the Indemnitee has been successful, on the merits or otherwise, in defense of any Proceeding or in defense of any claim, issue or matter therein (other than a Proceeding referred to in
Section 6), the Indemnitee shall be indemnified against all Expenses actually and reasonably incurred by or on behalf of the Indemnitee in connection therewith. Without limiting the foregoing,
if any Proceeding or any claim, issue or matter therein is disposed of, on the merits or otherwise (including a disposition without prejudice), without (i) the disposition being adverse to the
Indemnitee, (ii) an adjudication that the Indemnitee was liable to the Corporation, (iii) a plea of guilty or nolo contendere by the
Indemnitee, (iv) an adjudication that the Indemnitee did not act in good faith and in a manner the Indemnitee reasonably believed to be in or not opposed to the best interests of the
Corporation, and (v) with respect to any criminal proceeding, an adjudication that the Indemnitee had reasonable cause to believe his or her conduct was unlawful, the Indemnitee shall be
considered for the purposes hereof to have been wholly successful with respect thereto. 

        5.    Indemnification for Expenses of a Witness.    To the extent that the Indemnitee is, by reason of the
Indemnitee's Corporate Status, a witness in any Proceeding to which the Indemnitee is not a party, the Indemnitee shall be indemnified against all Expenses actually and reasonably incurred by or on
behalf of the Indemnitee in connection therewith. 

        6.    Exceptions to Right of Indemnification.    Notwithstanding anything to the contrary in this Agreement, except as
set forth in Section 10, the Corporation shall not indemnify the Indemnitee in connection with a Proceeding (or part thereof) initiated by the Indemnitee unless (a) the initiation
thereof was approved by the Board or (b) the Proceeding was commenced following a Change in Control. Notwithstanding anything to the contrary in this Agreement, the Corporation shall not
indemnify the Indemnitee to the extent the Indemnitee is reimbursed from the proceeds of insurance, and in the event the Corporation makes any indemnification payments to the Indemnitee and the 

4

 

Indemnitee
is subsequently reimbursed from the proceeds of insurance, the Indemnitee shall promptly refund such indemnification payments to the Corporation to the extent of such insurance
reimbursement. 

        7.    Notification and Defense of Claim.    As a condition precedent to the Indemnitee's right to be indemnified, the
Indemnitee must notify the Corporation in writing as soon as practicable of any Proceeding for which indemnity will or could be sought. With respect to any Proceeding of which the Corporation is so
notified, the Corporation will be entitled to participate therein at its own expense and/or to assume the defense thereof at its own expense, with legal counsel reasonably acceptable to the
Indemnitee. After notice from the Corporation to the Indemnitee of its election so to assume such defense, the Corporation shall not be liable to the Indemnitee for any legal or other expenses
subsequently incurred by the Indemnitee in connection with such Proceeding, other than as provided below in this Section 7. The Indemnitee shall have the right to employ his or her own counsel
in connection with such Proceeding, but the fees and expenses of such counsel incurred after notice from the Corporation of its assumption of the defense thereof shall be at the expense of the
Indemnitee unless (i) the employment of counsel by the Indemnitee has been authorized by the Corporation, (ii) counsel to the Indemnitee shall have reasonably concluded that there may be
a conflict of interest or position on any significant issue between the Corporation and the Indemnitee in the conduct of the defense of such Proceeding or (iii) the Corporation shall not in
fact have employed counsel to assume the defense of such Proceeding, in each of which cases the fees and expenses of counsel for the Indemnitee shall be at the expense of the Corporation, except as
otherwise expressly provided by this Agreement, and provided that Indemnitee's counsel shall cooperate reasonably with the Corporation's counsel to minimize the cost of defending claims against the
Corporation and the Indemnitee. The Corporation shall not be entitled, without the consent of the Indemnitee, to assume the defense of any claim brought by or in the right of the Corporation or as to
which counsel for the Indemnitee shall have reasonably made the conclusion provided for in clause (ii) above. The Corporation shall not be required to indemnify the Indemnitee under this
Agreement for any amounts paid in settlement of any Proceeding effected without its written consent. The Corporation shall not settle any Proceeding in any manner that would impose any penalty or
limitation on the Indemnitee without the Indemnitee's written consent. Neither the Corporation nor the Indemnitee will unreasonably withhold or delay their consent to any proposed settlement. 

        8.    Advancement of Expenses.    In the event that the Corporation does not assume the defense pursuant to
Section 7 of any Proceeding of which the Corporation receives notice under this Agreement, any Expenses incurred by or on behalf of the Indemnitee in defending such Proceeding shall be paid by
the Corporation in advance of the final disposition of such Proceeding; provided, however, that the payment of such Expenses incurred by or on behalf of
the Indemnitee in advance of the final disposition of such Proceeding shall be made only upon receipt of an undertaking by or on behalf of the Indemnitee to repay all amounts so advanced in the event
that it shall ultimately be determined that the Indemnitee is not entitled to be indemnified by the Corporation as authorized in this Agreement. Such undertaking shall be accepted without reference to
the financial ability of the Indemnitee to make repayment. Any advances and undertakings to repay pursuant to this Section 8 shall be unsecured and interest free. 

        9.    Procedures.    

        (a)   In
order to obtain indemnification or advancement of Expenses pursuant to this Agreement, the Indemnitee shall submit to the Corporation a written request, including in
such request such documentation and information as is reasonably available to the Indemnitee and is reasonably necessary to determine whether and to what extent the Indemnitee is entitled to
indemnification or advancement of Expenses. Any such indemnification or advancement of Expenses shall be made promptly, and in any event within (i) in the case of indemnification under
Sections 4, 5 or 9(d) or advancement of Expenses, 30 days after receipt by the Corporation of the 

5

 

written
request of the Indemnitee, or (ii) in the case of all other indemnification, 60 days after receipt by the Corporation of the written request of the Indemnitee, unless with
respect to requests under Sections 3(a) or 3(b) (but, for avoidance of doubt, not with respect to requests for indemnification under Sections 4, 5 or 9(d) or requests for advancement of
Expenses under Section 8) the Corporation determines, by clear and convincing evidence, within the 60-day period referred to above that the Indemnitee did not meet the applicable
standard of conduct set forth in Section 3(a) or 3(b), as the case may be. Such determination, and any determination that advanced Expenses must be repaid to the Corporation, shall be made as
follows: 

        (x)   if
a Change in Control shall have occurred, by Special Independent Counsel in a written opinion to the Board, a copy of which shall be delivered to the Indemnitee
(unless the Indemnitee shall request that such determination be made by the Board, in which case the determination shall be made in the manner provided below in clauses (y)(1) or (y)(2)). 

        (y)   in
all other cases, in the discretion of the Board, (1) by a majority vote of the directors of the Corporation consisting of persons who are not at that time
parties to the Proceeding ("disinterested directors"), whether or not a quorum, (2) by a committee of disinterested directors designated by a majority vote of disinterested directors, whether
or not a quorum, (3) if there are no disinterested directors, or if the disinterested directors so direct, by independent legal counsel in a written opinion to the Board, or (4) by the
stockholders of the Corporation. 

        (b)   In
the event that a Change in Control shall have occurred and the determination of entitlement to indemnification is to be made by Special Independent Counsel, the
Special Independent Counsel shall be selected as provided in this Section 9(b). The Special Independent Counsel shall be selected by the Indemnitee, unless the Indemnitee shall request that
such selection be made by the Board. The party making the determination shall give written notice to the other party advising it of the identity of the Special Independent Counsel so selected. The
party receiving such notice may, within seven days after such written notice of selection shall have been given, deliver to the other party a written objection to such selection. Such objection may be
asserted only on the ground that the Special Independent Counsel so selected does not meet the requirements of "Special Independent Counsel" as defined in Section 2, and the objection shall set
forth with particularity the factual basis of such assertion. Absent a proper and timely objection, the person so selected shall act as Special Independent Counsel. If a written objection is made, the
Special Independent Counsel so selected may not serve as Special Independent Counsel unless and until a court has determined that such objection is without merit. If, within 20 days after
submission by the Indemnitee of a written request for indemnification, no Special Independent Counsel shall have been selected or if selected, shall have been objected to, in accordance with this
paragraph either the Corporation or the Indemnitee may petition the Court of Chancery of the State of Delaware or other court of competent jurisdiction for resolution of any objection which shall have
been made by the Corporation or the Indemnitee to the other's selection of Special Independent Counsel and/or for the appointment as Special Independent Counsel of a person selected by the court or by
such other person as the court shall designate, and the person with respect to whom an objection is favorably resolved or the person so appointed shall act as Special Independent Counsel. The
Corporation shall pay the reasonable and necessary fees and expenses of Special Independent Counsel incurred in connection with its acting in such capacity. The Corporation shall pay any and all
reasonable and necessary fees and expenses incident to the procedures of this paragraph, regardless of the manner in which such Special Independent Counsel was selected or appointed. Upon the due
commencement of any judicial proceeding pursuant to Section 10 of this Agreement, any Special Independent Counsel shall be discharged and relieved of any further responsibility in such capacity
(subject to the applicable standards of professional conduct then prevailing). 

6

 

        (c)   The
termination of any Proceeding by judgment, order, settlement, conviction or upon a plea of nolo contendere or its
equivalent, shall not, of itself, create a presumption that the Indemnitee did not act in good faith and in a manner which the Indemnitee reasonably believed to be in, or not opposed to, the best
interests of the Corporation, and, with respect to any criminal Proceeding, had reasonable cause to believe that his or her conduct was unlawful. 

        (d)   The
Indemnitee shall cooperate with the person, persons or entity making such determination with respect to the Indemnitee's entitlement to indemnification, including
providing to such person, persons or entity upon reasonable advance request any documentation or information which is not privileged or otherwise protected from disclosure and which is reasonably
available to the Indemnitee and reasonably necessary to such determination. Any costs or Expenses incurred by the Indemnitee in so cooperating shall be borne by the Corporation (irrespective of the
determination as to the Indemnitee's entitlement to indemnification) and the Corporation hereby indemnifies the Indemnitee therefrom. 

        10.    Remedies.    The right to indemnification or advancement of Expenses as provided by this Agreement shall be
enforceable by the Indemnitee in any court of competent jurisdiction if the Corporation denies such request, in whole or in part, or if no disposition thereof is made within the applicable period
referred to in Section 9. Unless otherwise required by law, the burden of proving that indemnification or advancement of Expenses is not appropriate shall be on the Corporation. Neither the
failure of the Corporation to have made a determination prior to the commencement of such action that indemnification is proper in the circumstances because the Indemnitee has met the applicable
standard of conduct, nor an actual determination by the Corporation that the Indemnitee has not met such applicable standard of conduct, shall be a defense to the action or create a presumption that
the Indemnitee has not met the applicable standard of conduct. The Indemnitee's Expenses actually and reasonably incurred in connection with successfully establishing the Indemnitee's right to
indemnification, in whole or in part, in any such Proceeding shall also be indemnified by the Corporation. 

        11.    Partial Indemnification.    If the Indemnitee is entitled under any provision of this Agreement to
indemnification by the Corporation for some or a portion of the Expenses, judgments, fines, penalties or amounts paid in settlement actually and reasonably incurred by or on behalf of the Indemnitee
in connection with any Proceeding but not, however, for the total amount thereof, the Corporation shall nevertheless indemnify the Indemnitee for the portion of such Expenses, judgments, fines,
penalties or amounts paid in settlement to which the Indemnitee is entitled. 

        12.    Subrogation.    In the event of any payment under this Agreement, the Corporation shall be subrogated to the
extent of such payment to all of the rights of recovery of the Indemnitee, who shall execute all papers required and take all action necessary to secure such rights, including execution of such
documents as are necessary to enable the Corporation to bring suit to enforce such rights. 

        13.    Term of Agreement.    This Agreement shall continue until and terminate upon the later of (a) six years
after the date that the Indemnitee shall have ceased to serve as a director or officer of the Corporation or, at the request of the Corporation, as a director, officer, partner, trustee, member,
employee or agent of another corporation, partnership, joint venture, trust, limited liability company or other enterprise or (b) the final termination of all Proceedings pending on the date
set forth in clause (a) in respect of which the Indemnitee is granted rights of indemnification or advancement of Expenses hereunder and of any proceeding commenced by the Indemnitee pursuant
to Section 10 of this Agreement relating thereto. 

        14.    Indemnification Hereunder Not Exclusive.    The indemnification and advancement of Expenses provided by this
Agreement shall not be deemed exclusive of any other rights to which the Indemnitee may be entitled under the Certification of Incorporation, the By-Laws, any other agreement, any vote of
stockholders or disinterested directors, the General Corporation Law of Delaware, any other law 

7

 

(common
or statutory), or otherwise, both as to action in the Indemnitee's official capacity and as to action in another capacity while holding office for the Corporation. Nothing contained in this
Agreement shall be deemed to prohibit the Corporation from purchasing and maintaining insurance, at its expense, to protect itself or the Indemnitee against any expense, liability or loss incurred by
it or the Indemnitee in any such capacity, or arising out of the Indemnitee's status as such, whether or not the Indemnitee would be indemnified against such expense, liability or loss under this
Agreement; provided that the Corporation shall not be liable under this Agreement to make any payment of amounts otherwise indemnifiable hereunder if and to the extent that the Indemnitee has
otherwise actually received such payment under any insurance policy, contract, agreement or otherwise. 

        15.    No Special Rights.    Nothing herein shall confer upon the Indemnitee any right to continue to serve as an
officer or director of the Corporation for any period of time or at any particular rate of compensation. 

        16.    Savings Clause.    If this Agreement or any portion thereof shall be invalidated on any ground by any court of
competent jurisdiction, then the Corporation shall nevertheless indemnify the Indemnitee as to Expenses, judgments, fines, penalties and amounts paid in settlement with respect to any Proceeding to
the full extent permitted by any applicable portion of this Agreement that shall not have been invalidated and to the fullest extent permitted by applicable law. 

        17.    Counterparts.    This Agreement may be executed in any number of counterparts, each of which shall constitute
the original. 

        18.    Successors and Assigns.    This Agreement shall be binding upon the Corporation and its successors and assigns
and shall inure to the benefit of the estate, heirs, executors, administrators and personal representatives of the Indemnitee. 

        19.    Headings.    The headings of the paragraphs of this Agreement are inserted for convenience only and shall not
be deemed to constitute part of this Agreement or to affect the construction thereof. 

        20.    Modification and Waiver.    This Agreement may be amended from time to time to reflect changes in Delaware law
or for other reasons. No supplement, modification or amendment of this Agreement shall be binding unless executed in writing by both of the parties hereto. No waiver of any of the provisions
of this Agreement shall be deemed or shall constitute a waiver of any other provision hereof nor shall any such waiver constitute a continuing waiver. 

        21.    Notices.    All notices, requests, demands and other communications hereunder shall be in writing and shall be
deemed to have been given (i) when delivered by hand or (ii) if mailed by certified or registered mail with postage prepaid, on the third day after the date on which it is so mailed: 

(a)    if
to the Indemnitee, to: [            ] 

(b)    if
to the Corporation, to: 

Millennium
Pharmaceuticals, Inc.

40 Landsdowne Street

Cambridge, MA 02139

Telephone: (617) 679-7000

Fax: (617) 374-7788

Attn: General Counsel 

or
to such other address as may have been furnished to the Indemnitee by the Corporation or to the Corporation by the Indemnitee, as the case may be. 

        22.    Applicable Law.    This Agreement shall be governed by, and construed and enforced in accordance with, the laws
of the State of Delaware. The Indemnitee may elect to have the right to indemnification or reimbursement or advancement of Expenses interpreted on the basis of the 

8

 

applicable
law in effect at the time of the occurrence of the event or events giving rise to the applicable Proceeding, to the extent permitted by law, or on the basis of the applicable law in effect
at the time such indemnification or reimbursement or advancement of Expenses is sought. Such election shall be made, by a notice in writing to the Corporation, at the time indemnification or
reimbursement or advancement of Expenses is sought; provided, however, that if no such notice is given, and if the General Corporation Law of Delaware is amended, or other Delaware law is enacted, to
permit further indemnification of the directors and officers, then the Indemnitee shall be indemnified to the fullest extent permitted under the General Corporation Law, as so amended, or by such
other Delaware law, as so enacted. 

        23.    Enforcement.    The Corporation expressly confirms and agrees that it has entered into this Agreement in order
to induce the Indemnitee to continue to serve as an officer or director of the Corporation, and acknowledges that the Indemnitee is relying upon this Agreement in continuing in such capacity. 

        24.    Entire Agreement.    This Agreement sets forth the entire agreement of the parties hereto in respect of the
subject matter contained herein and supercedes all prior agreements, whether oral or written, by any officer, employee or representative of any party hereto in respect of the subject matter contained
herein; and any prior agreement of the parties hereto in respect of the subject matter contained herein is hereby terminated and cancelled. For avoidance of doubt, the parties confirm that the
foregoing does not apply to or limit the Indemnitee's rights under Delaware law or the Corporation's Certificate of Incorporation or By-Laws. 

        25.    Consent to Suit.    In the case of any dispute under or in connection with this Agreement, the Indemnitee may
only bring suit against the Corporation in the Court of Chancery of the State of Delaware. The Indemnitee hereby consents to the exclusive jurisdiction and venue of the courts of the State of
Delaware, and the Indemnitee hereby waives any claim the Indemnitee may have at any time as to forum non conveniens with respect to such venue. The Corporation shall have the right to institute any
legal action arising out of or relating to this Agreement in any court of competent jurisdiction. Any judgment entered against either of the parties in any proceeding hereunder may be entered and
enforced by any court of competent jurisdiction. 

        IN
WITNESS WHEREOF, the parties hereto have caused this Agreement to be duly executed as of the day and year first above written. 

	 	 	 	MILLENNIUM PHARMACEUTICALS, INC.
	

Attest:	

 	
 	

By:	

 
	 	 	 	 	

	

By:	

 	
 	

Name:	

 
	 	
	 	 	

	

Name:	

 	
 	

Title:	

 
	 	
	 	 	

	

Title:	

 	
 	

 	

 
	 	
	 	 	 

	 

	

 	

 	
 	

INDEMNITEE:	

 
	

 	

 	
 	

9

QuickLinks

Exhibit 10.58

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00137-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00137-of-00352.parquet"}]]