Document:

Filed by Automated Filing Services Inc. (604) 609-0244 - Medicure Inc. - Exhibit 4-Q

  INVESTOR RELATIONS AND CONSULTING AGREEMENT 

THIS AGREEMENT made effective the 15th Day of December, 2002.

BETWEEN:

 Medicure Inc.  

   (hereinafter the “Corporation”) 

 OF THE FIRST PART 

 -and- 

 NOBLE HOUSE CAPITAL CORP.  

  (hereinafter the “Noble House”) 

 OF THE SECOND PART 

WHEREAS:

	 	A.
 	The Corporation is a reporting issuer
        in the Province(s) of Alberta, British Columbia and Ontario;

	 	 	 
	 	B.	The Corporation is desirous of obtaining
        the services of a firm to handle all investor relations matters for the
        Corporation; and

	 	 	 
	 	C.	The Corporation wishes to retain the
        services of Noble House and compensate it accordingly.

                 NOW
  THEREFORE THIS AGREEMENT WITNESSETH that in consideration of the premises
  and of the mutual covenants herein contained, the parties hereto covenant and
  agree as follows: 

 1              Engagement
  of Noble House 

 The Corporation hereby agrees to engage and retain Noble House
  to perform the services hereinafter defined and Noble House hereby accepts such
  retainer to perform the services hereinafter defined on the terms and conditions
  set forth herein. 

 2

 2              Term

 The term of this Agreement shall extend from December 15th,
  2002, for a period of 6 months ending June 15th, 2003 (the “Term”).
  The Agreement may be terminated by either party at the end of each three-month
  period by providing written notice of its intention to the other party. Following
  the end of the Term, the parties hereto may mutually agree to any renewals of
  this Agreement for a time period to be discussed. 

 3              Obligations
  of Noble House

	3.1 	Noble House agrees to manage
        and control; all of the investor relations needs of the Corporation during
        the Term in a faithful, diligent and honest manner including, without
        limiting the generality of the foregoing, performance of the following
        duties: 

	 	 	 
	 	3.1.1 	communicating with investment dealers,
        advisors and shareholders, both current and prospective, with a view to
        increasing awareness of and interest in the Corporation; 

	 	 	 
	 	3.1.2 	maintaining an orderly market in the Corporation’s securities;
    
	 	 	 
	 	3.1.3 	promoting the Corporation in a positive manner at all times
      and developing and expanding the Corporation’s shareholder base; 
	 	 	 
	 	3.1.4 	assisting the Corporation in identifying
        and securing new sources of capital through public or private offerings
        for debt or equity securities as the need arises; 

	 	 	 
	 	3.1.5 	coordinating regular meetings between the Corporation, investment
      dealers, advisors, analysts and shareholders; 
	 	 	 
	 	3.1.6 	assisting the Corporation with marketing
        materials and media relations including the preparation and dissemination
        of information through press releases, provided that, the Corporation
        has adequately reviewed and approved such information prior to its release
        to the public; 

	 	 	 
	 	3.1.7	providing analysis and advice with respect
        to the Corporation’s capital structure and the potential financial
        impact of any proposed capital expenditures; and 

	 	 	 
	 	3.1.8 	assisting the Corporation with respect
        to any due diligence required in relation to any proposed transaction
        if, and when, required. 

	 	 	 
	In the performance of the
        foregoing duties, Noble House shall report to the Corporation on a regular
        basis as reasonably required by the Corporation and at no time will a
        finders’ fee be payable to Noble House by the Corporation. 

 3

 4              Confidentiality

 Except as directed by the Corporation, required by law or
  required in the course of providing the services described herein, the Consultant
  shall not, either during the term of this Agreement or at any time thereafter,
  use, supply, show or disclose to any person, firm or corporation any secret
  or proprietary information, knowledge or data concerning the business, affairs,
  products or prospects of the Corporation which the Consultant may have acquired
  at any time prior to this Agreement, in the course of or incidental to this
  Agreement or otherwise, for the Consultant's own benefit, or to the detriment,
  or intended or probable detriment, of the Corporation. 

5              Remuneration
	5.1	During the Term, the Corporation
        agrees to pay Noble House, as compensation for services rendered a fee
        of $4000.00 per month (Cdn) plus GST, payable on the fifteenth day of
        each month commencing December 15, 2002.

	 	 	 
	5.2	The Corporation agrees to
        reimburse Noble House for all reasonable expenses incurred by it in the
        provision of its services to the Corporation, provided, such expenses
        have been approved by the Corporation in advance. Such payments shall
        be made promptly upon receipt by the Corporation of an invoice for such
        expenses.

	 	 	 
	6 	Stock Options
	 	 	 
	6.1 	Noble House shall receive
        stock options to purchase 100,000 shares of the Corporation’s listed
        common shares (the “Option”) upon execution of this Agreement.

	 	 	 
	 	6.1.1 	The options to purchase common shares, the exercise
        price, the vesting schedule, the applicable hold period and the expiry
        date of the such options are subject to all stock exchange polices and
        applicable securities laws; and

	 	 	 
	 	6. 1. 2 	At no time shall the number of options granted to
        Noble House as compensation exceed an aggregate of 2% of the Corporation’s
        issued and outstanding shares.

	 	 
	6.2 	
        Notwithstanding the foregoing, upon the making of an Offer (as hereinafter
          defined), the Option shall become immediately exercisable in respect
          of any and all shares covered thereby and in respect of which Noble
          House has not previously exercised the right to acquire shares under
          the Option. For the purposes of this paragraph, “Offer” means
          an offer made generally to the holders of the Corporation’s voting
          securities in one or more jurisdictions to purchase directly or indirectly
          voting securities of the Corporation where the voting securities which
          are the subject of the offer to purchase together with the offeror’s
          then presently owned securities will in the aggregate exceed 20% of
          the outstanding voting securities of the Corporation, and, in this regard,
          where two or more persons, corporations or other entities make an offer
          or offers jointly or in concert or intend to exercise jointly or in
          concert any voting rights attaching to the securities to be acquired,
          then the securities owned by each of them shall be included in the calculation
          of the percentage of the outstanding voting securities of the Corporation
          owned by the offeror.

         50,000 shares vest immediately upon execution of this agreement
          at $0.50 per share.

         50,000 shares vest on March 15th, 2003
          at $0.75 per share.

      

 4

 7              Termination

 If either party breaches any provisions, conditions or covenants
  of this Agreement, the other party shall have the right, without prejudice to
  any other rights it may have under the circumstances, to terminate this Agreement
  by giving the breaching party thirty (30) days written notice of such termination,
  specifying therein the grounds upon which said notice is based; and, provided
  that if such breach or default can be remedied and if the breaching party within
  said thirty day period shall in fact remedy or cure the breach or default, then
  such notice shall not become effective and this Agreement shall remain in force
  and effect. 

 If Noble House shall cease to be a consultant of the Corporation
  or any of its subsidiaries or affiliates as the case may be , for any reason,
  it may but only within sixty (60) days next succeeding its ceasing to be a consultant
  exercise his Share Option to the extent that he was entitled to exercise it
  at the date of such cessation. 

 8              Notices

 All notices, communications, statements and invoices (hereinafter called "Notices")
required or permitted hereunder shall be in writing. Notices may be served in
the following manner: 

	8.1 	Personally by leaving them with the party on whom
        they are to be served at that party's address hereinafter given. Personally
        served Notices shall be deemed received by the addressee when actually
        delivered, provided such delivery shall be during normal business hours;
        or 

	 	 
	8.2 	By mailing them in Canada by first class, registered
        post, postage prepaid, to the party on whom they are to be served. Notices
        so served shall be deemed to be received by the addressee on the fourth
        day (excluding as the fourth day Saturdays, Sundays and statutory holidays)
        following the mailing thereof. 

	 	 
	The address of each of the respective parties
      hereto for service of Notices shall be as follows: 
	 	 
	 	The Corporation: 

       Medicure Inc.  

        4 – 1200 Waverly Street

        Winnipeg, MB 

        R3T-0P4 

        Attention: Dr. Albert D. Friesen 

       Noble House: 

        Noble House Capital Corp. 

        Suite #450, Manulife House 

        603 – 7th Avenue SW 

        Calgary, AB T2P 2T5 

        Attention: Mr. Dan M. Patience 

 5

 9              Severability

 Every provision of this Agreement is intended to be severable.
  If any term or provision is illegal, invalid or unenforceable for any reason
  whatsoever, such illegality, invalidity or unenforceability shall not affect
  the validity of the remainder of this Agreement. 

 10             Consents
  and Waivers 

 No consent or waiver, express or implied, by any party hereto
  to or of any breach or default by any other party hereto in the performance
  of any obligations hereunder shall be deemed or construed to be a consent or
  waiver to or of any other breach or default in the performance by such other
  party of the same or any other obligation of such party hereunder. Failure on
  the part of any party to complain of any act or failure to act of any other
  party or to declare any party to be in breach or default, irrespective of how
  long such failure continues, shall not constitute a waiver by such party of
  his or its rights hereunder. 

 11             Applicable
  Law 

 This Agreement shall be governed by and construed in accordance
  with the laws of the Province of Alberta and each of the parties hereto agrees
  to attorn to the jurisdiction of the courts of Alberta for any dispute arising
  out of or in connection with this Agreement. 

 12             Entire
  Agreement 

 This Agreement and any Schedules attached hereto, constitute
  and express the whole agreement of the parties hereto with reference to the
  engagement and retainer of the Consultant by the Corporation and with reference
  to any of the matters and things herein provided for or hereinbefore discussed
  or mentioned with reference to such engagement and retainer, all promises, representations
  and undertakings relative thereto being hereby merged herein. 

 13             Time

 Time is of the essence of this Agreement. 

 14             Enurement

 This Agreement shall enure to the benefit of and be binding
  upon the parties hereto and their respective heirs, executors, administrators,
  successors and assigns. 

 6

 15             Regulatory
  Approvals 

 The engagement of Noble House may be subject to regulatory
  approval including without limitation the approval of any stock exchange on
  which shares of the Corporation may be listed. The Corporation agrees to diligently
  pursue any and all regulatory approvals necessary for the engagement of Noble
  House and the granting of options under clause 6.1 hereof and shall provide
  Noble House with copies of such approvals upon receipt of same. 

 IN WITNESS WHEREOF the parties hereby have duly executed
  this Agreement as of the day, month and year first above written. 

	WITNESS: ________________________________________	   	________________________________________
	 	 	Dan Patience
	 	 	President,
	 	 	Noble House Capital Corp.
	 	 	 
	 	 	 
	 	 	 
	 	 	 
	 	 	 
	 	 	 
	 	 	 
	WITNESS: ________________________________________	 	________________________________________
	 	 	Dr. Albert D. Friesen
	 	 	President, Chairman & CEO
	 	 	Medicure Inc.Filed by Automated Filing Services Inc. (604) 609-0244 - Medicure Inc. - Exhibit 4-R

 April 28, 2003 

 

Dear Mr. Dubé:

 Re: Amendment of Consulting Services Agreement (the “Agreement”)

 This letter, once executed, will constitute an amendment to the Agreement
  dated March 28, 2002. The original wording of Section 3.2 and 3.3 of the Agreement
  is hereby replaced with the following: 

   "In consideration of the Consultant providing the services required of it
    under the terms of this Agreement, the Corporation shall pay to the Consultant
    a fee of $3,000 per month (the "Fee") together with GST payable thereon. In
    addition, the Corporation will allow the Consultant to retain the existing
    140,000 stock options that have been granted subject to the terms of a stock
    option agreement. No additional options will be granted during the Term. The
    Fee shall be paid on the last day of each month during the Term hereof.”
  

All other terms, covenants and conditions remain in force in accordance with the original agreement as dated March 28, 2002

Upon execution of the agreement, please return one original to our office and retain the other for your files.

Best Regards,

 _______________________________

  Albert D. Friesen 

  President 

  

Accepted and agreed: ____________________________

                                         
  Jean-François Dubé

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