Document:

GlaxoSmithKline plc S-8

 

Exhibit 4.3

 

AMENDMENT
NO. 1 

TO
THE 

GSK
401(k) PLAN 

(effective
January 1, 2017)

 

 

 

Pursuant
to resolutions of the Board of Managers of GlaxoSmithKline LLC, adopted December 15, 2017, the GSK 401(k) Plan (the “Plan”)
is amended as follows, effective as of January 1, 2017, except as otherwise provided herein:

 

1.            The
definition of “Roth Contribution Account” under the definition of “Account” in Article I of the Plan is
hereby amended in its entirety to read as follows:

 

“‘Roth
Contribution Account’ – the Account to which are credited a Participant’s Roth Contributions, adjusted for income,
gains and losses thereon.”

 

2.             Effective
as of the applicable dates of transfer referenced below, the definition of “Prior Company Matching Contribution” in
Article I of the Plan is hereby amended by adding new subsections (l), (m) and (n) each reading as follows:

 

“(l)         Effective
on the date of the transfer of plan assets into the Plan, for purposes of Section 6.4, amounts denominated under the Novamin Technology,
Inc. Retirement Plan and Trust as “matching contributions” and “non-elective contributions,” “profit
sharing contributions”, “discretionary contributions,” or any other employer contributions, plus any earnings
or minus any losses thereon;

 

(m)         Effective
on the date of the transfer of plan assets into the Plan, for purposes of Section 6.4, amounts denominated under the Tempero 401K
Plan as “matching contributions” and “non-elective contributions,” “profit sharing contributions”,
“discretionary contributions,” or any other employer contributions, plus any earnings or minus any losses thereon;
and

 

(n)          Effective
on the date of the transfer of plan assets into the Plan, for purposes of Section 6.4, amounts denominated under the Human Genome
Sciences, Inc. 401(k) Plan as “matching contributions” and “non-elective contributions,” “profit
sharing contributions”, “discretionary contributions,” or any other employer contributions, plus any earnings
or minus any losses thereon.”

 

3.            The
definition of “Roth Contributions” in Article I of the Plan is hereby amended in its entirety to read as follows:

 

“‘Roth
Contributions’ means, for any Participant, designated contributions described in section 402A(c)(1) of the Code made
on or after October 1, 2009 pursuant to Section 3.1.1.2 by the Company at the Participant’s election; provided that
Roth Contributions shall also include amounts denominated as Roth contributions as described in section 402A(c)(1) of the
Code under a plan merged into the Plan or a plan of which its assets or portion of its assets are transferred to the
Plan.”

 

     

     

    

 

4.            Effective
March 5, 2013, Section 6.1.3 of the Plan is hereby amended by in its entirety to read as follows:

 

“6.1.3.
The total amount of his Prior Company Matching Contribution Account and that portion of the Puerto Rico Employee Account, if any,
attributable to such Prior Company Matching Contributions; provided, however, that the portion of the Prior Company Matching Contribution
Account attributable to Human Genome Sciences, Inc. 401(k) Plan was not eligible for regular withdrawals pursuant to this Section
6.1 between March 5, 2013 and May 31, 2017.”

 

5.            Schedule
B of the Plan is hereby amended by adding the following to the Acquisition Table:

 

	Acquired
    / Affiliated Company	Eligibility
    Service Effective Date
	NovaMin
    Technology, Inc.	December
    21, 2010
	Human
    Genome Sciences, Inc.	September,
    24, 2012 or December 17, 2012
	Tempero
    Phamaceuticals, Inc.	October
    20, 2014

  

Executed
this ___ day of December, 2017.

 

	 	GLAXOSMITHKLINE LLC
	 	 	 
	 	By: 	 
	 	 	 

 

    - 2 -GlaxoSmithKline plc S-8

 

Exhibit 4.4

  

AMENDMENT
NO. 2 

TO
THE 

GSK
401(k) PLAN 

(Effective
April 1, 2017)

 

 

 

Pursuant
to resolutions of the Board of Managers of GlaxoSmithKline LLC approved on December 20, 2018, the GSK 401(k) Plan (the “Plan”)
is amended as follows, effective as of October 5, 2018:

 

1.       
   Section 5.2.1 is hereby amended in its entirety to read as follows:

 

“5.2.1. Forms
of Distribution. A Participant who has a Separation from Service, whether before or after his Early Retirement Date (but not
including a Separation from Service by reason of death), shall have his nonforfeitable interest paid to him or applied for his
benefit in one of the following forms:

 

5.2.1.1.
Partial Distribution. Effective on and after October 5, 2018, a Participant may elect to have his Account paid to him,
or applied for his benefit, in partial distributions of no less than $10,000 per distribution. No more than four (4) partial distributions
may be elected by a Participant in any Plan Year. The portion of the Participant’s Account that remains following a partial
distribution shall continue to be adjusted to reflect any gains, losses, income and expenses of the Fund. At any time after having
received one or more partial distributions, a Participant may elect, in the form and manner required by the Committee, to receive
his remaining Account paid in the form of a single sum payment or in installments as permitted in accordance with this Section
5.2.1.

 

5.2.1.2.
Single Sum Payment. A Participant may elect to have his Account paid to him in a single sum payment.

 

5.2.1.3.
Installments. A Participant may elect to have the Account paid to him, or applied for his benefit, in annual installments
over a period not extending beyond 5 years (or 20 years for distributions made on and after January 1, 2016) or, if shorter, the
life expectancy of the Participant or the joint life expectancy of the Participant and the Participant’s beneficiary. Installments
are an available form of benefit only if the Participant’s Account is more than $5,000 (as determined pursuant to Section
5.2.2.3). While any annual installments remain unpaid, the value of the Participant’s Account shall continue to be adjusted
to reflect any gains, losses, income and expenses of the Fund. A Participant may elect, in the form and manner required by the
Committee, to accelerate the payment of the Account and receive a single sum payment.

 

5.2.1.4.
Limited Annuity Right for ARI Plan Benefit. A Participant may elect to have the portion of his Account that is attributable
to the benefit transferred from the ARI Plan, paid to him, or applied for his benefit, in the form of a single life annuity or
a joint and survivor annuity with a survivor percentage from 50 to 100 percent. The annuity forms of benefit provided in this
Section 5.2.1.4 are eliminated ninety days after provision of the required notice, but not before October 22, 2002.”

 

     

     

    

 

2.
          Section 5.2.2.1 is hereby amended in its entirety to read as follows:

 

“5.2.2.1.
His interest shall be paid to him or applied for his benefit upon the earliest of the following times:

 

(A)       on
his Required Beginning Date, in an amount that is no less than the amount required to be distributed to the Participant pursuant
to the minimum distribution rules of section 401(a)(9) of the Code;

 

(B)        as
soon as practicable following his application (in accordance with the notice provisions of Section 11.12) for a distribution;
or

 

(C)        as
soon as practicable following the date of his death.” 

 

Executed
this ___ day of _____________, 2018. 

 

	 	GLAXOSMITHKLINE LLC
	 	 	 
	 	By:GlaxoSmithKline plc S-8

 

Exhibit 4.5

 

AMENDMENT
NO. 3 

TO
THE 

GSK
401(k) PLAN 

(Effective
April 1, 2017)

 

 

 

Pursuant
to resolutions of the Board of Managers of GlaxoSmithKline LLC approved on ____________ __, 2019, the GSK 401(k) Plan (the “Plan”)
is amended as follows, effective as of June 21, 2019:

 

1.            Section
6.3.1 is hereby amended in its entirety to read as follows:

 

“6.3.1.
Amount of Hardship Withdrawal. If the Accounts available for regular withdrawal pursuant to Section 6.1 have been exhausted,
a Participant who is an Employee may withdraw amounts credited to his Pre-Tax Contribution Account, as well as any pre-tax contributions
credited to his Puerto Rico Employee Account (including any earnings thereon), and after such contributions are exhausted, amounts
credited to his Roth Contribution Account, less any amounts previously withdrawn from any such accounts, by submitting his request
(in accordance with the notice provisions of Section 11.12) to the Company within such period of time as may be designated by
the Committee and pursuant to the rules set forth in this Section 6.3.”

 

2.            Section
6.3.4.2 is hereby amended in its entirety to read as follows:

 

“6.3.4.2.
The Participant has obtained all distributions currently permissible (other than hardship distributions); and the Participant
represents that the need cannot be relieved through reimbursement or compensation by insurance or otherwise; by reasonable liquidation
of the Participant’s assets and/or borrowing from commercial sources on reasonable commercial terms (to the extent that
such liquidation or loan would not itself cause an immediate and heavy financial need) or by cessation of Pre-Tax Contributions
and Roth Contributions under the Plan; and the Committee determines that it is reasonable under all of the facts and circumstances
to rely on such representation. ”

 

3.            Section
6.3.5 is hereby deleted in its entirety and its provisions shall cease to apply with respect to all Participants effective immediately. 

 

Executed
this ___ day of _____________, 2019.

 

	 	GLAXOSMITHKLINE LLC
	 	 	 
	 	By:GlaxoSmithKline plc S-8

 

Exhibit 4.6

 

	 

                                                                                                                                                                                      GSK
        PUERTO RICO 401(K) PLAN

         

        (As
        Amended and Restated Effective April 1, 2013)

         

 

     

     

    

 

TABLE
OF CONTENTS

 

Page

 

	ARTICLE I	INTRODUCTION	1
	ARTICLE II	DEFINITIONS	2
	ARTICLE III	TRANSITION AND ELIGIBILITY TO PARTICIPATE	9
	 	3.1	Rights Affected and Preservation of Accrued Benefits	9
	 	3.2	Eligibility to Participate	9
	 	3.3	Corporate Transactions	10
	 	3.4	Election to Make Pre-Tax and/or After-Tax Contributions	10
	 	3.5	Data	10
	 	3.6	Beneficiary Designation	11
	 	3.7	Other Plans	11
	ARTICLE IV	PARTICIPANT AND COMPANY CONTRIBUTIONS	12
	 	4.1	Pre-Tax Contributions	12
	 	4.2	After-Tax Contributions	12
	 	4.3	Rollover Contributions	12
	 	4.4	Change or Suspension in Contributions	13
	 	4.5	Company Matching Contributions	13
	 	4.6	GSK Core Contributions	14
	 	4.7	Reversion	14
	 	4.8	Section 1081.01(d) Nondiscrimination Tests	14
	 	4.9	Treatment of Allocable Excess Pre-Tax Contributions	17
	 	4.10	Maximum Allocation – PR Code Section 1081.01(a)(11(B)	18
	ARTICLE V	PARTICIPANTS’ ACCOUNTS	19
	 	5.1	Credits to Participants’ Accounts	19
	 	5.2	Investment of Accounts Other than GSK Core Contributions
Account	19
	 	5.3	Investment of After-Tax Contribution
    Account 	20
	 	5.4	Valuation of Accounts	20
	 	5.5	Dividends on Employer Stock	20
	 	5.6	Participants Right to Diversify	20
	 	5.7	Effect of Distributions and Withdrawals	20
	 	5.8	Accounting for Allocations	20
	 	5.9	Partial Investment in Cash or Obligations	20
	 	5.10	Investment in Puerto Rico Property	20
	 	5.11	Active Participant Vesting	20
	ARTICLE VI 	DISTRIBUTIONS UPON SEPARATION FROM SERVICE	21
	 	6.1	Distribution Upon Separation from Service	21
	 	6.2	Distribution Upon Death	21
	 	6.3	Form of Payment	21
	 	6.4	Direct Rollover	21

 

 

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	ARTICLE VII WITHDRAWALS DURING EMPLOYMENT	22
	 	7.1	In General	22
	 	7.2	Voluntary Withdrawals	22
	 	7.3	Withdrawal of Pre-January 1, 1994 Contributions and Earnings	22
	 	7.4	Hardship Withdrawals	22
	ARTICLE VIII ADMINISTRATION	24
	 	8.1	Plan Administrator	24
	 	8.2	Named Fiduciary	24
	 	8.3	Rules of Administration	24
	 	8.4	Duties and Powers of GlaxoSmithKline or its Designated
Representative	24
	 	8.5	Services to the Plan	25
	 	8.6	Funding Policy	25
	 	8.7	Records and Reports	25
	 	8.8	Claims Procedure	25
	 	8.9	Indemnification	26
	 	8.10	Notice of Address and Missing Persons	26
	 	8.11	Effect of a Mistake	27
	ARTICLE IX MANAGEMENT OF FUNDS	28
	 	9.1	Trust Agreement	28
	 	9.2	Contributions	28
	 	9.3	Non-reversion	28
	 	9.4	Rights in the Trust Fund	28
	ARTICLE X AMENDMENT, TERMINATION, AND MERGERS	29
	 	10.1	Amendment	29
	 	10.2	Termination	29
	 	10.3	Merger or Consolidation	30
	ARTICLE XI PARTICIPATION IN AND WITHDRAWAL FROM THE PLAN BY AN AFFILIATED COMPANY	31
	 	11.1	Participation in the Plan	31
	 	11.2	Withdrawal from the Plan	31
	ARTICLE XII GENERAL PROVISIONS	32
	 	12.1	Source of Benefits	32
	 	12.2	No Employment Rights	32
	 	12.3	Alienation	32
	 	12.4	Distribution Pursuant to a Qualified Domestic Relations Order	32
	 	12.5	Withholding	33
	 	12.6	Voting Rights	33
	 	12.7	Tender Offers	33
	 	12.8	Facility of Payment	33
	 	12.9	Applicability of the Plan	33
	 	12.10	Notice	33
	 	12.11	Construction of Plan	33
	 	12.12	Gender and Number	33
	 	12.13	Headings	34

 

 

     - ii -

     

    

 

	 	12.14	Governmental Approval	34
	 	12.15	Uniformity	34
	 	12.16	Severability	34
	APPENDIX A	 	35
	Affiliated Companies Participating in the Plan	35

 

 

     - iii -

     

    

 

GSK
PUERTO RICO 401(K) PLAN

 

(As
Amended and Restated Effective April 1, 2013)

 

ARTICLE
I

INTRODUCTION

 

The
objective of the Plan is to encourage the employees who reside in the Commonwealth of Puerto Rico and work for businesses affiliated
with GlaxoSmithKline plc that have adopted the Plan to save on a regular basis toward retirement. The Plan is now amended and
restated to reflect current changes in applicable law and best administrative practices.

 

It
is intended that this amended and restated profit sharing plan continue to be qualified under Sections 1081.01(a) and (d)
of the Puerto Rico Internal Revenue Code of 2011, as amended (“PR Code”), that it also meet the requirements of Section
1081.01(g) of the PR Code, and the trust created to fund the Plan will continue to be exempt from taxation under Section 1081.01(a)
of the PR Code.

 

     

     

    

 

ARTICLE
II

DEFINITIONS

 

Whenever
used in the Plan the following terms shall have the respective meanings set forth below unless a different meaning is clearly
required by the context in which the term is used, use of a term in one gender shall not exclude the other gender for the definition:

 

“Account”
means the separate account maintained for each Participant which represents the Participant’s total proportionate interest
in the several investment funds maintained under the Plan and which consists of the sum of the following sub-accounts, which in
each case shall include any contributions of the same type credited under a plan merged into the Plan:

 

(a)          “After-Tax
Contributions Account” shall include the balance of any Basic and Additional Contributions Accounts in the Plan as of
March 31, 1998 (as defined then), After-Tax Contributions and any gains and losses of the Trust Fund attributable thereto.

 

(b)          “Company
Matching Contributions Account” shall be allocated Company Matching Contributions and any gains or losses of the Trust
Fund attributable thereto.

 

(c)          “GSK
Core Contributions Account” shall be allocated the GSK Core Contributions, and any gains or losses of the Trust Fund
attributable thereto.

 

(d)          “Pre-Tax
Contributions Account” shall be allocated Pre-Tax Contributions and any gains and losses of the Trust Fund attributable
thereto.

 

(e)          “Prior
Company Matching Contributions Account” shall include the balance of any Company Matching Contributions as of March
31, 1998 (as defined then), 1165(e) Matching Contributions Accounts in the Plan as of June 30, 2001 (as defined then) and Company
Matching Contributions made under the Block Drug Co. Savings Plan as of May 22, 2002 (as defined therein) and, any gains and losses
of the Trust Fund attributable thereto.

 

(f)           “Rollover
Contributions Account” shall be allocated any Rollover Contributions, and any gains or losses of the Trust Fund attributable
thereto.

 

“Actual
Deferral Percentage” or “ADP” means the ratio (expressed as a percentage calculated to two
(2) decimal points) of Pre-Tax Contributions made on behalf of the eligible Employees for the Plan Year to the eligible Employee’s
Compensation for the Plan Year.

 

“Affiliated
Company or Companies” means:

 

(a)          any
corporation, partnership or other entity which is a member of a controlled group of corporations (as defined in Section 1010.04
of the PR Code) which includes GlaxoSmithKline plc;

 

(b)          any
group of entities (whether or not incorporated) which are related (as defined in Section 1010.05 of the PR Code) with GlaxoSmithKline
plc; and

 

(c)          any
corporation, partnership or other entity that is part of an affiliated service group (as defined in Section 1081.01(a)(14)(B)
which includes GlaxoSmithKline plc or is under common control with GlaxoSmithKline plc, that have employees who are bona-fide
residents of Puerto Rico.

 

 

    - 2 -

     

    

 

“After-Tax
Contributions” means the voluntary contributions made by a Participant, as described in Section 4.2.

 

“Allocable
Excess Pre-Tax Contributions” shall mean the amount of Pre-Tax Contributions for a calendar year that the Participant
allocates to this Plan pursuant to the claim procedure described in Section 4.9 hereof.

 

“Average
Actual Deferral Percentage” or “Average ADP” means the average (expressed as a percentage
calculated to two (2) decimal points) of the Actual Deferral Percentages (ADPs) of the eligible Employees in a group.

 

“Beneficiary”
means the person or persons designated under Section 3.6 to receive benefits under the Plan upon the death of a Participant.

 

“Block
Drug Co. Savings Plan” means the plan that transferred into the Plan effective May 22, 2002.

 

“Board
of Directors” means the Board of Directors of GlaxoSmithKline Puerto Rico, Inc.

 

“Business
Day” means any working day within the Plan Year in which the Plan record keeper is open for business.

 

“Catch-up
Contributions” means the voluntary contributions made by a Participant in excess of the Pre-Tax Contribution limitations
contained in the Plan, as described in Section 4.1.2.

 

“Code”
means the United States Internal Revenue Code of 1986, as amended and its enabling regulations or any legislation superseding
the Code. Any reference to a section of the Code shall also be a reference to the appropriate section of any legislation superseding
the Code.

 

“Company”
means GlaxoSmithKline Puerto Rico, Inc., a Puerto Rico corporation, or any successor corporation resulting from merger, consolidation,
or transfer of assets substantially as a whole, which shall expressly agree in writing to continue the Plan.

 

“Company
Matching Contributions” means the contributions made by the Employer.

 

“Compensation”
means, for each Employee:

 

(a)           For any Plan Year commencing prior to January 1, 2012, the Employee’s total taxable income under the PR Code received from
the Employer with respect to such Plan Year, including, but not limited to, base earnings, regularly scheduled variable incentive
pay and bonuses (including Christmas bonuses) , overtime, shift differential, but excluding special bonuses and awards, income
recognized in connection with stock-related options and payments, reimbursements and other expense allowances, fringe benefits
(cash and noncash), moving expenses, deferred compensation, welfare benefits, severance or separation pay and any amounts paid
prior to beginning participation in the Plan, as determined pursuant to guidelines established and revised by the Employer from
time to time and communicated to Employees. Solely for the purpose of computing the GSK Core Contribution, Compensation shall
include amounts paid to an Employee under a short term disability program sponsored by the Employer or maintained pursuant to
legal requirements.

 

 

    - 3 -

     

    

 

(b)          For any Plan Year commencing on or after January 1, 2012, the lesser of the amounts described in paragraph (a) above and $250,000
(or such other amount as may be applicable under section 401(a)(17) of the Code).

 

“Computation
Period” means, with respect to any Employee, the twelve (12) consecutive month period that begins on his Employment
Commencement Date or Reemployment Commencement Date and all calendar years that begin after his Employment Commencement Date or
Reemployment Commencement Date.

 

“Disability”
means, with respect to any Participant, a disability with respect to which he is eligible for and receiving benefits under a long
term disability plan sponsored by the Company or an Affiliated Company.

 

“Effective
Date” means April 1, 2013. The original effective date of this Plan is January 1, 1974.

 

“Eligible
Retirement Plan” for purposes of Section 4.3 means a retirement plan which complies with the requirements of PR Code
Section 1081.01. For all other purposes shall also mean an individual retirement account or individual retirement annuity described
in Section 1081.02 of the PR Code and such other retirement arrangements eligible to receive a distribution from the Plan, as
may be provided through amendment to the PR Code.

 

“Eligible
Rollover Distribution” means any distribution of all the balance to the credit of a participant in an Eligible Retirement
Plan due to a Separation from Service.

 

“Employee”
means an individual (other than a Leased Employee) who is employed by the Company or a Participating Company at their Puerto Rico
locations and who is also a bona fide resident of Puerto Rico (within the meaning of U.S. Treasury Regulation Section 1.501(a)-l(e)).
There shall be included within this definition interns, co-ops and full and part-time temporary employees, who are on a Participating
Company’s payroll.

 

“Employer”
means the Company and all Affiliated Companies.

 

“Employer
Stock Fund” means an investment fund consisting primarily of ADSs.

 

“Employment
Commencement Date” means, for each Employee, the date on which he completes his first Hour of Service. Unless the
Company shall expressly determine otherwise, and except as is expressly provided otherwise in this Plan, an Employee shall not,
for the purposes of determining his/her Employment Commencement Date, be deemed to have commenced employment with an Affiliated
Company prior to the effective date on which the entity became an Affiliated Company.

 

“ERISA”
means the Employee Retirement Income Security Act of 1974, as amended.

 

“GSK
Core Contribution” means the amounts contributed by the Employer, as described in Section 4.6.

 

 

    - 4 -

     

    

 

“GlaxoSmithKline”
means GlaxoSmithKline LLC, a Delaware limited liability company.

 

“Highly
Compensated Employee” means each Employee who:

 

(a)          during the Plan Year for which the determination is being made was more than a 5% owner or had more than a 5% interest in earnings
or capital of the Employer;

 

(b)          received Compensation during the preceding Plan Year from the Employer in excess of the PR Code Section 1081.01(d)(3)(E)(iii)(III)
limit; or

 

(c)          is an officer of the Employer.

 

“Hour
of Service” means for any Employee, a credit awarded with respect to:

 

(a)          Except
as provided in Subsection (b),

 

(1)          Each
hour for which he directly or indirectly is paid or entitled to payment by the Employer for the performance of employment duties;

 

(2)          Each
hour for which he is entitled, either by award or agreement, to back pay from the Employer, irrespective of mitigation of damages;

 

(3)          Each
hour for which he directly or indirectly is paid or entitled to payment by the Employer on account of a period of time during
which no duties are performed due to vacation, holiday, illness, incapacity (including disability), jury duty, layoff, or leave
of absence;

 

(4)          In
accordance with the Uniformed Service Employment and Reemployment Rights Act of 1994, service credited with respect to qualified
military service in accordance with Code Section 414(u);

 

(5)          Any
unpaid family or medical leave required to be credited by law; provided that the Employee returns to employment with the Employer
at the expiration of the leave; or

 

(6)          Each
hour of otherwise regularly scheduled work missed by reason of disability leave of absence from the Employer.

 

(b)          Notwithstanding
anything to the contrary in Subsection (a):

 

(1)          No
Hours of Service shall be credited to an Employee for any period merely because, during such period, payments are made or due
him under a plan maintained solely for the purpose of complying with applicable workers’ compensation, unemployment compensation,
or disability insurance laws.

 

(2)          No
Hours of Service shall be credited to an Employee with respect to payments solely to reimburse for medical or medically-related
expenses.

 

(3)          No
Hours of Service shall be credited twice.

 

(4)          Hours
of Service for the performance of duties shall be credited to the Employee for the Period of Service in which the services
are performed. Hours of Service for back pay shall be credited to the Employee for the Period of Service to which the award
or agreement pertains rather than the Period of Service in which the back pay award was made.

 

 

    - 5 -

     

    

 

(5)          Hours
of Service shall be credited at least as liberally as required by the rules set forth in U.S. Department of Labor Reg. §2530.200b-2(b)
and (c).

 

(6)          In the case of an Employee who is such solely by reason of service as a Leased Employee, Hours of Service shall be credited as
if such Employee were employed and paid with respect to such service (or with respect to any related absences or entitlements)
by the Participating Company or Affiliated Company that is the recipient thereof.

 

“Investment
Fund” means each of the funds, excluding the Employer Stock Fund, with varying investment objectives approved by
the Plan Administrator as an investment media for the Trust Fund in accordance with Article 5 The Plan Administrator shall
have discretion in establishing and terminating such funds as it shall deem appropriate.

 

“Leased
Employee” means any person, other than an employee of a Participating Company or an Affiliated Company, who, pursuant
to an agreement between a Participating Company or an Affiliated Company (the “recipient”) and any other individual
(“leasing organization”), has performed services for the recipient (or for the recipient and related individuals)
on a substantially full-time basis for a period of at least one year, and such services are performed by such individuals
under the primary direction and control of the recipient, provided that for purposes of determining whether an individual is an
Employee and for purposes of determining an individual’s eligibility and vesting service, an individual who would be a “Leased
Employee” but for the requirement that such individual perform services for the recipient (or for the recipient and related
individuals) on a substantially full-time basis for a period of at least one year shall nevertheless be treated as a Leased Employee.
An individual shall not retroactively become an Employee even if such individual is subsequently treated or classified as an employee
for any purpose by any party that does not include eligibility to participate in the Plan.

 

“Non-highly
Compensated Employee” means an Employee who is not a Highly Compensated Employee.

 

“Normal
Retirement Age” means 65 years of age.

 

“Participant”
means an Employee who having met the applicable eligibility requirements of Article 3 has an Account balance. A Participant who
is an Employee may be referred to as an active Participant. A Participant who is no longer an Employee on a Participating Company’s
payroll may be referred to as an inactive Participant.

 

“Participating
Company” means the Company and all Affiliated Companies listed in Appendix A.

 

“Payroll
Period” means the weekly, bi-weekly, semi-monthly, or monthly pay period for which an Employee receives compensation
from a Participating Company; provided that if a Participant ceases to be an Employee, only the Payroll Period including the date
on which the Employee ceases to be an Employee shall be considered a “Payroll Period.”

 

 

    - 6 -

     

    

 

“Period
of Service” means for any Employee, the elapsed time between an Employee’s Employment Commencement Date and
the date of reference, inclusive, and disregarding any Period of Severance or any period during which he is not an Employee to
the extent such period falls within a period of at least 12 consecutive months in which he has a Separation from Service by reason
of resignation, discharge, or attainment of Normal Retirement Date and completes no Hours of Service as described in Subparagraph
(a)(1) of the definition of “Hour of Service”. The number of full years in an Employee’s Period of Service shall
be determined by aggregating non-contiguous periods within his Period of Service. For the aggregation of Periods of Service, 365
days of service shall constitute a whole year.

 

“Period
of Severance” means, for any former Employee, a period of at least 12 consecutive months following a Separation
from Service during which he is credited with no Hours of Service as described in Subparagraph (a)(1) of the definition of “Hour
of Service”.

 

“Plan”
means the GSK Puerto Rico 401(k) Plan, formerly known as the GSK Puerto Rico Retirement Savings Plan.

 

“Plan
Administrator” means GlaxoSmithKline or such other person(s) appointed by the Board of Directors to act as such.

 

“Plan
Year” means the calendar year.

 

“PR
Code” means the Puerto Rico Internal Revenue Code of 2011, as amended and its enabling regulations or any legislation
superseding the PR Code. Any reference to a section of the PR Code shall also be a reference to the appropriate section of any
legislation superseding the PR Code.

 

“Pre-Tax
Contributions” means the voluntary contributions made by a Participant, as described in Section 4.1.

 

“Prior
Company Matching Contributions” means:

 

(a)          The balance of any Company Matching Contributions as of March 31, 1998 (as defined then),;

 

(b)          The balance of 1165(e) Matching Contributions Accounts in the Plan as of June 30, 2001 (as defined then); and 

 

(c)          Company Matching Contributions made under the Block Drug Co. Savings Plan as of May 22, 2002 (as defined therein).

 

“Reemployment
Commencement Date” means the first day following a one-year Period of Severance on which an Employee is entitled
to be credited with an Hour of Service described in Paragraph (a)(i) of the definition of “Hour of Service” in this
Article 2.

 

“Rollover
Contributions” means the contributions made by a Participant, as described in Section 4.3.

 

 

    - 7 -

     

    

 

“Separation
from Service” means:

 

The
date, as recorded on the records of the Employer, on which an Employee of such company quits, retires, is discharged, or dies,
or, if earlier, the first anniversary of the first day of a period during which the Employee remains absent from service with
the Employer (with or without pay) for any other reason, except:

 

(a)           Solely
for purposes of determining whether a one-year Period of Severance has occurred, if the Employee is absent from work beyond the
first anniversary of the first day on which he is absent by reason of pregnancy, childbirth, or placement in connection with adoption,
or for purposes of the care of such Employee’s child immediately after birth or placement in connection with adoption, the
date of such Employee’s Separation from Service shall be the second anniversary of the first day of such absence; or

 

(b)          If
the Employee is absent for military service under leave granted by the Employer or required by law, the Employee shall not be
considered to have a Separation from Service, provided the absent Employee returns to service with the Employer within 90 days
of his release from active military duty or any longer period during which his right to reemployment is protected by law.

 

“Share”
means one American Depository Share (“ADS”) equivalent to two ordinary shares of GlaxoSmithKline plc, and which is
readily tradable on an established securities market.

 

“Spouse”
or “spouse” means, effective on and after June 26, 2013, with respect to any Participant, a person of the
opposite sex of the Participant (or deceased Participant) who is (or was) a husband or wife, or a person of the same-sex as the
Participant (or deceased Participant) who is or was legally married to the Participant in any state or foreign jurisdiction that
recognizes such marriage (and regardless of where the couple lives or lived).

 

“Trust
Agreement” means the agreement of trust under which the Trustee serves.

 

“Trust
Fund” means the assets of every kind and description held by the Trustee under the Trust Agreement.

 

“Trustee”
means a trustee selected by the Plan Administrator pursuant to Section 12.1.

 

“Valuation
Date” means each day the New York Stock Exchange is open for trading, or such other day as the Plan Administrator
shall determine.

 

 

    - 8 -

     

    

 

ARTICLE
III

TRANSITION
AND ELIGIBILITY TO PARTICIPATE

 

3.1          Rights
Affected and Preservation of Accrued Benefits. Except as provided to the contrary herein, any Employee or former Employee
who is not an Employee on or after April 1, 2013 shall have his Account maintained under the Plan, but shall have his
rights and benefits determined solely under the Plan as in effect immediately prior to April 1, 2013.

 

3.2          Eligibility
to Participate. Each Employee eligible to participate in the Plan as of March 31, 2013 shall continue to be eligible to
participate in the Plan as of April 1, 2013, if he is then an Employee. Each Employee who is not eligible to participate in the
Plan as of March 31, 2013 shall become eligible to participate in the Plan (if he is then an Employee) immediately upon employment.

 

3.2.1       Pre-Tax
Contributions. For purposes of making Pre-Tax Contributions pursuant to Section 4.1:

 

3.2.1.1 
Each Employee shall be eligible to make Pre-Tax Contributions on and after the first day that he is credited with an Hour of Service
as an Employee. Except as set forth in Sections 3.2.2.1 and 3.2.2.2, an Employee shall become a Participant in the Plan by electing
to make Pre-Tax Contributions or Rollover Contributions as described in Section 4.1.

 

3.2.1.2 
A Participant who ceases to be an Employee and who later becomes an Employee, shall be eligible to become a Participant as of
the date on which he first again completes an Hour of Service as an Employee.

 

3.2.2      
Company Contributions.

 

3.2.2.1
         Company Matching Contribution.

 

(A)         Employees. All Employees shall be eligible to participate in the Company Matching Contribution pursuant to Section 4.5
commencing with the first Payroll Period in which they are credited with a one-year Period of Service.

 

(B)         Rehired Participants.

 

(1)          Any
Employee who was previously eligible for a matching contribution pursuant to the Plan or the Block Drug Plan, shall be eligible
to receive Company Matching Contributions as of the date on which he first again completes an Hour of Service as an Employee.

 

(2)          Any Employee who was previously a participant in the Plan or the Block Drug Plan, but was not eligible for a matching contribution
pursuant to the terms of such plan, shall be eligible to receive Company Matching Contributions in accordance with Section 3.2.2.1(A),
taking into account Periods of Service credited under the terms of such plan; provided that if the Employee had no vested interest
in employer contributions under the applicable plan as of such Employee’s Separation from Service, Periods of Service credited
before the Separation from Service shall not be taken into account after the Employee again becomes an Employee if the Employee’s
consecutive one-year Periods of Severance equals or exceeds the greater of (i) 5 or (ii) the aggregate number of years of service
before such Period of Severance.

 

 

    - 9 -

     

    

 

3.2.2.2         
GSK Core Contributions Account.

 

(A)         Employees. All Employees shall be eligible to participate in the GSK Core Contribution commencing with the first Payroll
Period in which they are credited with a one-year Period of Service.

 

(B)         Rehired Participants.

 

(1)          Any Employee who was previously eligible for GSK Core Contributions pursuant to the Plan shall be eligible for GSK Core Contributions
as of the date on which he first again completes an Hour of Service as an Eligible Employee.

 

(2)          Any Employee who was previously a participant in (A) the Plan but was not eligible for GSK Core Contributions, or (B) the Block
Drug Plan but was not credited with a one-year period of service pursuant to the terms of such applicable plan, shall be eligible
for GSK Core Contributions in accordance with Section 4.6, taking into account Periods of Service credited under the terms of
such plan; provided that if the Employee had no vested interest in employer contributions under the applicable plan as of such
Employee’s Separation from Service, Periods of Service credited before the Separation from Service shall not be taken into
account after the Employee again becomes an Employee if the Employee’s consecutive one-year Periods of Severance equals
or exceeds the greater of (i) 5 or (ii) the aggregate number of years of service before such Period of Severance.

 

3.3          Corporate
Transactions. Except as otherwise provided in this Section 3.3, an individual who becomes an Employee as the direct result
of a Corporate Transaction shall not be treated as an Employee before he is first credited with an Hour of Service. 

 

3.4          Election to Make Pre-Tax and/or After-Tax Contributions. Each Employee may elect to make Pre-Tax and/or After-Tax
Contributions as soon as practicable by filing advance notice, as provided in Section 12.10, of such election with the Company
within such period of time as may be designated by the Plan Administrator. Such notice shall authorize the Company to reduce such
Employee’s salary by an amount determined in accordance with Section 4.1 and to make Pre-Tax Contributions on such Employee’s
behalf in the amount of such reduction and/or to make After-Tax Contributions on such Employee’s behalf.

 

3.5          Data. Each Employee shall furnish to the Company such data as the Company may consider necessary for the determination
of the Employee’s rights and benefits under the Plan and otherwise shall cooperate fully with the Company in the administration
of the Plan.

 

 

    - 10 -

     

    

 

3.6        
Beneficiary Designation.

 

3.6.1      
When applying for participation in the Plan or when he first becomes eligible to receive a GSK Core Contribution pursuant to Section
4.6, an Employee shall designate, in the manner specified by the Plan Administrator, and in no other, a Beneficiary or Beneficiaries
to whom his Account shall be paid in the event of his death. Each Participant’s Beneficiary shall be his surviving spouse
unless the Participant has designated a different Beneficiary and the Participant’s spouse has consented to that designation
in writing in an instrument that acknowledges the effect of the designation and is witnessed by a notary public, or the Plan Administrator
concludes that such consent cannot be obtained because the Participant has no spouse, because the spouse cannot be located or
because of such other circumstances, as provided by applicable law. A Participant may change his Beneficiary designation at any
time by written notice to the Plan Administrator in a form approved by the Plan Administrator, except that no change in Beneficiary
designation may be made which does not conform to the rules contained in this Section 3.6.

 

3.6.2      
If a Participant’s spouse is the Participant’s Beneficiary, upon the dissolution of the marriage of the Participant,
the designation of the Participant’s former spouse as a Beneficiary shall continue in effect until the Participant remarries
or executes another Beneficiary designation that complies with Section 3.6.

 

3.7         Other
Plans. An Employee who is credited with employer contributions under any other savings plan maintained by the Employer
shall be ineligible to participate in the Plan.

 

 

    - 11 -

     

    

 

ARTICLE
IV

PARTICIPANT
AND COMPANY CONTRIBUTIONS

 

4.1          Pre-Tax
Contributions.

 

4.1.1       Each
active Participant may file an election under Section 3.4 to have a percentage of his Compensation (in 1% increments), not to
exceed the lesser of 50% of his Compensation or the limit contained in Section 1081.01(d)(7) of the PR Code ($10,000 for 2011;
$13,000 for 2012 and $15,000 for 2013 and thereafter until amended), contributed by the Company as Pre-Tax Contributions for credit
to the Eligible Employee’s Pre-Tax Contribution Account. Such contribution shall be made no less frequently than monthly.

 

4.1.2       Each
active Participant who attains age 50 or more during the Plan Year shall be eligible to make Catch-up Contributions of up to the
limit provided in Section 1081.01(d)(7)(C) of the PR Code ($1,500 for 2013). Catch-up Contributions shall not be subject to the
limitations contained in Section 4.1.1, the nondiscrimination tests of Section 4.8 nor the Allocable Pre-Tax Contributions provisions
of Section 4.9. Catch-up contributions shall not be eligible for Company Matching Contributions. Catch-up Contributions shall
be contributed by the Employer to the Plan on behalf of the Participant in lieu of an equal amount being paid to him as Compensation.

 

4.1.3       The
Plan Administrator shall have the right to establish rules with respect to the making of Pre-Tax and Catch-up Contributions elections
pursuant to this Section 4.1, including without limitation, the right to require that any such election be made at such time prior
to its becoming effective and to restrict the active Participant’s right to change such election. Such Pre-Tax and Catch-up
Contributions are intended to be treated for Puerto Rico income tax purposes as contributions made by the Employer under a qualified
cash or deferred arrangement (as defined in PR Code Section 1081.01(d)), but shall be treated as if they were contributions by
an active Participant for the purpose of the Plan except where the Plan expressly indicates otherwise.

 

4.2          After-Tax
Contributions. Each active Participant may contribute from 1% to 10% of his Compensation as an After-Tax Contribution
in 1% increments. After-Tax Contributions will be made through payroll deduction after the active Participant files the corresponding
form with the Employer in accordance with the provisions of Section 3.4. After-Tax Contributions shall be delivered to the
Trustee as soon as administratively possible within or following the applicable payroll period but not beyond the expiration of
the period granted for such purposes by applicable law or regulation.

 

4.3          Rollover
Contributions. Each active Participant may transfer to the Plan all, or a portion designated by the Participant, of an
Eligible Rollover Distribution. If such transfer is not a direct transfer, such a transfer may be made only if the transfer occurs
on or before the 60th day following the Employee’s receipt of the distribution from the Eligible Retirement Plan.

 

The
Plan Administrator shall develop such procedures, and may require such information, from an active Participant desiring to make
such a transfer, as it deems necessary or desirable to determine that the proposed transfer will meet the requirements of this
Section. Upon approval by the Plan Administrator, the amount transferred shall be deposited in the Trust Fund and shall be credited
to the Participant’s Account. Such rollover amount shall be one hundred percent (100%) vested in the Participant.

 

 

    - 12 -

     

    

 

4.4          Change
or Suspension in Contributions. Subject to the provisions of Sections 4.1 and 4.2, an active Participant may
prospectively change the percentage of his rate of Pre-Tax Contributions or After-Tax Contributions to a higher or lower percentage
or amount, by giving notice to the Plan Administrator in the manner and pursuant to the rules established by the Plan Administrator.
A Participant shall not be permitted to make up any Pre-Tax Contributions or After-Tax Contributions which are omitted as a result
of a reduction in rate or amount.

 

A
Participant may suspend his Pre-Tax Contributions or After-Tax Contributions at any time. Such suspension shall become effective
as soon as practicable following receipt by the Company of the notice of suspension, in accordance with Section 12.10, provided
such notice is received within the period of time designated by the Plan Administrator.

 

4.5          Company
Matching Contributions. Except as provided in Article 6:

 

4.5.1       For
each Participant who has completed a one-year Period of Service, each Payroll Period the Employer shall contribute to the Plan
an amount equal to each active Participant’s Pre-Tax Contributions but not in excess of 4% of the Participant’s Compensation
for such payroll period.

 

4.5.2       In
the event an active Participant’s Pre-Tax Contribution is limited by operation of law to an amount that is less than 4%
of such active Participant’s Compensation and the active Participant is making After-Tax Contributions in an amount which
when added to the active Participant’s Pre-Tax Contributions is greater than or equal to 4% of the active Participant’s
Compensation, the Employer, in addition to the contribution described in Section 4.5.1, will contribute an amount equal to the
active Participant’s After-Tax Contribution up to a maximum of the difference between 4% of the active Participant’s
Compensation and the Company Matching Contribution computed on the active Participant’s Pre-tax-Contributions as limited
by operation of law. Company Matching Contributions made as a result of this Section 4.5.2 shall be subject to the same restrictions
as all other Company Matching Contributions.

 

4.5.3       In
satisfaction of its obligation under this Section 4.5, the Employer shall pay its contribution in cash or securities.

 

4.5.4       Company
Matching Contributions shall be made out of the current or accumulated earnings of the Employer.

 

4.5.5       Company
Matching Contributions made with respect to any calendar quarter shall be made no later than the last day of the following calendar
quarter.

 

4.5.6       Each
Company Matching Contribution to the Plan is conditioned on its deductibility. To the extent permitted under applicable law, in
the event that the Secretary of the Puerto Rico Department of the Treasury determines that the Plan does not qualify for tax-exempt
status under PR Code Section 1081.01 and issues an adverse determination with respect to its continued qualification, Company
Matching Contributions made on or after the date on which such determination or refusal is applicable shall, at the Employer’s
discretion, be returned to the Employer without interest within one year after such determination, but only if the application
for determination is made by the time prescribed by law for filing the Employer’s income tax return for the taxable year in which
the Plan was adopted, or such later date as the Secretary of the Puerto Rico Department of the Treasury may prescribe.

 

 

    - 13 -

     

    

 

4.5.7       To
the extent permitted by applicable law, in the event that a Company Matching Contribution to the Plan is made by a mistake of
fact or all or part of the Employer’s deductions under PR Code Section 1033.09 for contributions to the Plan are disallowed
by the Puerto Rico Department of the Treasury, the portion of the contributions attributable to such mistake of fact or to which
such disallowance applies shall be returned to the Employer without interest. Any such return shall be made within one year after
the making of such contribution by mistake of fact or disallowance of deductions, as the case may be.

 

4.6          GSK
Core Contributions.

 

4.6.1       Each
Plan Year a GSK Core Contribution shall be made by the Employer not later than the time prescribed by law for the filing of the
Employer’s tax return for its taxable year within which such Plan Year ends, in an amount equal to two (2%) percent of Compensation
of each Employee for each payroll period during such Plan Year in which an Employee has satisfied the eligibility requirements
set forth in Section 3.2.2; provided that, for purposes of determining the amount of the GSK Core Contribution for any Employee,
only Compensation paid to an Employee for Payroll Periods on and after such Employee’s completion of the required Period
of Service shall be considered; provided further that if the date on which the one-year Period of Service is credited falls within
a Payroll Period, Compensation during the entire Payroll Period shall be eligible for GSK Core Contribution.

 

4.6.2       The
GSK Core Contributions shall be credited to each Participant’s GSK Core Contributions Account.

 

4.7
         Reversion. The Employer who makes a contribution as a mistake of fact,
or for which a tax deduction is disallowed, in whole or in part by the Puerto Rico Department of the Treasury, shall be entitled
to a refund of said contributions, which must be made within one year after payment of a contribution made as a mistake of fact,
or within one year after disallowance of the tax deduction, to the extent of such disallowance.

 

4.8          Section
1081.01(d) Nondiscrimination Tests.

 

4.8.1       Average
Actual Deferral Percentage Test (ADP Test).

 

4.8.1.1
   Notwithstanding anything in this Plan to the contrary, Pre-Tax Contributions made under the Plan (and any other Plan that is aggregated
with the Plan in accordance with PR Code Section 1081.01(d)(3)) by or on behalf of a Participant shall be restricted so as to
comply with one of the following ADP Tests.

 

(a)           1.25
Test. The Average ADP for Highly Compensated Employees for the Plan Year shall not exceed the Average ADP for Non-highly Compensated
Employees for the Plan Year multiplied by 1.25; or,

 

(b)           Two
Times/2% Test. The Average ADP for Highly Compensated Employees for the Plan Year shall not exceed the Average ADP for Non-highly
Compensated Employees for the Plan Year multiplied by 2, provided that the Average ADP for Highly Compensated Employees does not
exceed the Average ADP for Non-highly Compensated Employees by more than two (2) percentage points or such lesser amount, as may
be prescribed by law.

 

 

    - 14 -

     

    

 

The
Plan Administrator shall have the right to limit Pre-Tax Contributions of Highly Compensated Employees as, and to the extent that
it, in its discretion, deems necessary to comply with one of the above tests.

 

4.8.1.2    Determination of (ADP) Excess Pre-Tax Contributions.

 

(a)
          The amount of excess Pre-Tax Contributions for a Highly Compensated Employee will be determined in the following manner: First,
the ADP of the Highly Compensated Employee with the highest ADP is reduced to the extent necessary to satisfy the ADP Test or
cause such ratio to equal the ADP of the Highly Compensated Employee with the next highest ADP. Second, this process is repeated
with each successive Highly Compensated Employee until the ADP test is satisfied. The amount of excess Pre-Tax Contributions for
a Highly Compensated Employee is then equal to the excess of the total Pre-Tax Contributions taken into account for the ADP Test
over the product of (1) the Employee’s ADP following the reduction described above and (2) the Employee’s Compensation.
At the Plan Administrator’s discretion, which shall be uniformly applied, the excess Pre-Tax Contributions shall be distributed
to the Highly Compensated Employee as soon as administratively feasible but in no event later than twelve (12) months after the
close of the Plan Year to which the excess Pre-Tax Contributions relate. The amount of Company Matching Contributions attributable
to any portion of an Employee’s excess Pre-Tax Contributions shall be distributed.

 

(b)
          Income on an active Participant’s excess Pre-Tax Contributions shall be determined by multiplying the income allocated to
his Pre-Tax Contribution Account for the Plan Year in which such excess Pre-Tax Contribution was made by a fraction, the numerator
of which is the excess Pre-Tax Contributions for such Participant for the Plan Year, and the denominator of which is the total
Pre-Tax Contribution Account balance for such Participant as of the first day of the Plan Year, plus the Pre-Tax Contributions
made on behalf of the active Participant during the Plan Year.

 

(c)
          Upon the distribution of excess Pre-Tax Contributions the amount of income required to be distributed with respect to the period
between the last day of the Plan Year and the date on which the excess is distributed (the “gap period”) shall be 10%
of the amount of income allocable to excess Pre-Tax Contributions for the Participant determined pursuant to Section 4.8.1.2(b)
multiplied by the number of calendar months that have elapsed since the end of the Plan Year in which the excess Pre-Tax Contributions
were made. For purposes of determining the number of calendar months that have elapsed since the last day of the Plan Year, if
the distribution is made on or before the 15th day of the month, such month shall not be included, and if the distribution is
made after the 15th day of the month, such month shall be included.

 

 

    - 15 -

     

    

 

4.8.1.3    Special Rules.

 

(a)
          For purposes of this Section 4.8, the ADP for any Highly Compensated Employee who is eligible to have pre-tax contributions allocated
to his account under two or more plans or arrangements described in PR Code Section 1081.01(d) that are maintained by the Employer
shall be determined as if all such pre-tax contributions were made under a single arrangement.

 

(b)
          In the event that this Plan satisfies the requirements of PR Code Section 1081.01(a)(3) only if aggregated with one or more other
plans, if one or more other plans satisfy the requirements of PR Code Section 1081.01(a)(3) only if aggregated with this Plan,
or if the PR Code requires that one or more other plans be aggregated with the Plan for purposes of PR Code Section 1081.01(a)(3)
then this Section 4.8 shall be applied by determining the ADP as if all such plans were a single plan.

 

(c)
          The Plan Administrator may, to the extent permitted under the applicable PR Code regulations, recharacterize as After-Tax Contributions
for such Plan Year all or a portion of the Pre-Tax Contributions for Highly Compensated Employees to the extent necessary to comply
with the applicable limit set forth in Section 4.8.1, using the leveling method described in Section 4.8.1.2 above. Recharacterized
amounts shall remain non-forfeitable and subject to the same distribution requirements as Pre-Tax Contributions. Amounts may not
be recharacterized with respect to a Highly Compensated Employee to the extent that such amount, in combination with other After-Tax
Contributions made by such Employee, would exceed the limitations under the Plan with respect to After-Tax Contributions. Recharacterization
shall occur no later than 2-1/2 months after the last day of the Plan Year in which such excess Pre-Tax Contributions arose.

 

(d)
          The determination and treatment of the Pre-Tax Contributions and ADP of any active Participant shall satisfy such other requirements
as may be prescribed by the Secretary of the Puerto Rico Department of the Treasury, including the provisions of the applicable
PR Code regulations which are incorporated herein by reference.

 

(e)
          To the extent permitted by the PR Code, the Plan Administrator shall aggregate the Affiliated Companies for purposes of determining
compliance by the Plan with the ADP Test of PR Code Section 1081.01 and the determination of Highly Compensated Employees.

 

 

    - 16 -

     

    

 

4.8.2       Corrections
of Excess Pre-Tax Contributions and After-Tax Contributions.

 

4.8.2.1
   If the Plan Administrator shall determine that the Pre-Tax Contributions of one or more Participants might result in discrimination
in favor of Employees who are officers, shareholders or Highly Compensated Employees or cause the Plan to violate the requirements
for a cash or deferred arrangement under PR Code Section 1081.01(d), the Plan Administrator may adjust the past, current or future
Pre-Tax Contributions made on behalf of any such Participant in the manner provided in the applicable PR Code regulations, to
avoid such discrimination and satisfy the requirements of PR Code Section 1081.01(d). The Plan Administrator may recharacterize
any of such Participant’s Pre-Tax Contributions as current Compensation either to be distributed (along with income allocable
thereto) to the Participant or contributed as an After-Tax Contribution and subject to such terms and conditions
as will cause the Plan to meet the requirements for a qualified cash or deferred arrangement under PR Code Section 1081.01(d).
The decision of the Plan Administrator in this regard shall be final and shall not be subject to question by the Trustee, the
Employer or by any Participant. Any Pre-Tax Contributions that are recharacterized as After-Tax Contributions pursuant to this
Section 4.8.2.1 shall not be eligible to be matched with Company Matching Contributions unless subject to the special rule set
forth in Section 4.5.2.

 

4.8.2.2
   If the Plan Administrator shall determine that the After-Tax Contributions of any Participant might result in discrimination in
favor of employees who are officers, shareholders or Highly Compensated Employees, or cause the Plan to violate the requirements
of PR Code Section 1081.01(a)(4), the Plan Administrator may adjust past, current or future After-Tax Contributions of such Participants,
in the manner provided in the applicable PR Code regulations as will, in the Plan Administrator’s opinion, avoid such discrimination
and satisfy the requirements of PR Code Section 1081.01(a)(4). The Plan Administrator may distribute the After-Tax Contributions
(along with income allocable thereto) to the Participant as will cause the Plan to meet the requirements of PR Code Section 1081.01(a)(4).
The decision of the Plan Administrator in this regard shall be final and shall not be subject to question by the Trustee, the
Employer or by any Participant.

 

4.9          Treatment
of Allocable Excess Pre-Tax Contributions.

 

4.91        Notwithstanding
any other provision of the Plan, excess Pre-Tax Contributions and income allocable thereto shall be distributed no later than
each April 15 to Participants who claim Allocable Excess Pre-Tax Contributions for the preceding Plan Year.

 

4.9.2       The
Participant’s claim shall be in writing, shall be submitted to the Plan Administrator no later than March 1; shall specify
the Participant’s excess Pre-Tax Contributions for the preceding Plan Year; and shall be accompanied by the Participant’s
written statement that if such amounts are not distributed, such Allocable Excess Pre-Tax Contributions, when added to amounts
deferred under other plans or arrangements described in Section 1081.01(d) of the PR Code, exceeds the limit imposed on the Participant
by Section 1081.01(d)(7) of the PR Code for the year in which the Pre-Tax Contribution was made. 

 

4.9.3       The
Allocable Excess Pre-Tax Contributions distributed to a Participant with respect to a Plan Year shall be adjusted for income,
gains and losses thereon; provided, if there is a loss allocable to the excess Pre-Tax Contributions, the Allocable Excess Pre-tax
Contributions to be distributed shall in no event be less than the lesser of the Participant’s Pre-Tax Contributions Account
under the Plan or the Participant’s Pre-Tax Contributions for the Plan Year.

 

4.9.4       Notwithstanding
any other provision of the Plan, excess Pre-Tax Contributions which the Participant has not claimed to be Allocable Excess Pre-Tax
Contributions shall be, to the extent permitted under the applicable PR Code regulations, recharacterized as After-Tax Contributions.
Any Pre-Tax Contributions that are recharacterized as After-Tax Contributions pursuant to this Section 4.9 shall not be eligible
to be matched with Company Matching Contributions and any Company Matching Contributions made in respect of Pre-Tax Contributions
recharacterized as After-Tax Contributions shall be forfeited unless the requirements of Section 4.5.2 are met.

 

 

    - 17 -

     

    

 

4.10       
Maximum Allocation – PR Code Section 1081.01(a)(11(B).

 

4.10.1    
General Rule. Effective January 1, 2012, in no event shall amounts allocated to a Participant’s Account under the
Plan exceed the limitations set forth in Section 1081.01(a)(11)(B) of the PR Code, which are hereby incorporated into the Plan.

 

4.10.2   
 Treatment of Excess Annual Additions.

 

4.10.2.1          If the amount otherwise allocable to the Account of a Participant would exceed the amount described in Section 1081.01(a)(11)(B)
of the PR Code as a result of the reallocation of forfeitures, a reasonable error in estimating the Participant’s Compensation,
a reasonable error in determining the amount of Pre-Tax Contributions that may be made with respect to the Participant under the
limits of this Section 4.10.2, or such other circumstances as permitted by law, the Plan Administrator shall determine which portion,
if any, of such excess amount is attributable to the Participant’s Pre-Tax Contributions, Company Matching Contributions,
or GSK Core Contributions, if any, and the following rules shall apply:

 

4.10.2.2          Excess Pre-Tax Contributions and earnings thereon shall be paid to the Participant as soon as administratively feasible.

 

4.10.2.3          Excess amounts attributable to Company Matching Contributions or GSK Core Contributions shall be held in a suspense account by
the Trustee until the following Plan Year (or any succeeding Plan Year) at which time such amounts shall be used to reduce Company
Matching Contributions and/or GSK Core Contributions otherwise allocable to Participants for such Plan Year; amounts held in the
suspense account shall share in investment gains and losses of the Fund.

 

4.10.2.4          Notwithstanding anything in this Section 4.10 to the contrary the rule of Sections 4.10.1 and 4.10.2 shall be deemed amended to
comply with PR Code regulations that may be promulgated after January 1, 2011.

 

 

    - 18 -

     

    

 

ARTICLE
V

PARTICIPANTS’
ACCOUNTS

 

5.1
         Credits to Participants’ Accounts.

 

5.1.1       An
Account shall be established for each Participant. All Accounts shall be valued in United States dollars. A Participant shall
have a 100% non-forfeitable interest at all times in his Account. Notwithstanding the foregoing, with respect to an individual
who is a Participant solely by reason of having his Account merged into the Plan, any forfeitable interest in such Account shall
become 100% non-forfeitable upon such Participant becoming an Eligible Employee.

 

5.1.2       Contributions
shall be credited to each Participant’s Account in the following manner:

 

5.1.2.1    Pre-Tax Contributions shall be credited to his Pre-Tax Contribution Account;

 

5.1.2.2    After-Tax Contributions shall be credited to his After-Tax Contributions Account;

 

5.1.2.3    Company Matching Contributions shall be credited to his Company Matching Contribution Account;

 

5.1.2.4    GSK Core Contributions shall be credited to his GSK Core Contributions Account; and

 

5.1.2.5    Rollover Contributions shall be credited to his Rollover Contribution Account.

 

5.2          Investment
of Accounts. Until such time as the Plan Administrator may direct otherwise or unless specifically restricted for a particular
Investment Fund, each Participant may direct the Plan Administrator in the manner and pursuant to the rules established by the
Plan Administrator and under this Section 5.2, to invest the Participant’s Accounts, including the Participant’s GSK
Core Contributions Account. Such investments acquired in the manner prescribed by the Plan shall be held by or for the Trustee.
The amounts contributed by all Participants to each Investment Fund shall be commingled for investment purposes.

 

5.2.1       Until
a new investment direction is given to the Plan Administrator in the manner specified by the Plan Administrator, investment of
contributions to a Participant’s Account shall be governed by the investment direction last given by the Participant in
accordance with the Plan rules.

 

5.2.2       To
the extent permissible by law, no fiduciary (within the meaning given in Section 3(21)(A) of ERISA) shall be liable for any loss
which results from a Participant’s exercise or failure to exercise his investment election.

 

5.2.3       If
a Participant does not make an investment election, the Participant’s Account shall be invested in the age appropriate target
date fund offered in the Plan.

 

 

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5.3           Valuation
of Accounts.  As of the Valuation Date of an Investment Fund, the Trustee shall determine the fair market value
of each Investment Fund and the Plan Administrator shall determine the value of each Participant’s Account.

 

5.4           Dividends
on Employer Stock. Dividends on Shares in the Trust Fund shall be used to purchase additional Shares, or held in cash.
Reinvested dividends shall be allocated to a Participant’s Accounts based on the number of Shares held in each Account.

 

5.5           Participants
Right to Diversify. By providing prior notice, in accordance with Section 12.10, within such period of time as may be
designated by the Plan Administrator and pursuant to such other rules as may be determined by the Plan Administrator, a Participant
may transfer, effective as of such date determined by the Plan Administrator, such portion of the value of his Account (including
his GSK Core Contributions Account) in any Investment Fund to another Investment Fund, subject, however, to any transfer restrictions
that may be imposed by the Investment Fund. Any portion of the GSK Core Contributions Account that the Participant does not elect
to divest shall be invested in an age appropriate target date fund. The Plan Administrator shall establish reasonable periods
of time (which shall occur no less frequently than quarterly) and such other rules during which a Participant or beneficiary may
divest his GSK Core Contributions Account in accordance with this Section 5.5.

 

5.6           Effect
of Distributions and Withdrawals. If a distribution or withdrawal is made, the Participant’s appropriate Account
shall be reduced by the amount distributed or withdrawn. A distribution or withdrawal shall be paid as soon as practicable after
the distribution is due or the withdrawal is requested, pursuant to Articles 6 and 7 respectively.

 

5.7           Accounting
for Allocations. The Company shall establish or provide for the establishment of accounting procedures for the purpose
of making the allocations, valuations and adjustments to Participants’ Accounts provided for in this Article 5. From time
to time such procedures may be modified for the purpose of achieving equitable and non-discriminatory allocations among the Accounts
of Participants in accordance with the general concepts of the Plan and the provisions of this Article 5.

 

5.8           Partial
Investment in Cash or Obligations.  The Trustee may maintain in cash or short-term obligations such part of
the assets of each Investment Fund and the Employer Stock Fund as it shall deem necessary in its sole discretion.

 

5.9           Investment
in Puerto Rico Property.  If the Plan Administrator so decides, the Plan may provide investment options that
comply with the investment in Puerto Rico property requirement of PR Code Section 1081.01(b)(1)(B) that result in reduced taxation
and withholding on distributions to Participants.

 

5.10         Active
Participant Vesting.  A Participant who is an Employee on or after July 1, 2001 shall at all times be fully
vested and have a non-forfeitable interest in his Account.

 

 

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ARTICLE
VI

DISTRIBUTIONS
UPON SEPARATION FROM SERVICE

 

6.1          Distribution
Upon Separation from Service.

 

6.1.1       A
Participant’s Account shall be distributed in the form elected by the Participant as soon as reasonably practicable after
the Participant’s Separation from Service. If the vested portion of a Participant’s Account exceeds $5,000 (or such
higher amount as may be permitted under applicable law or regulation) or the Participant has not reached age 65, such distribution
of the Participant’s Account shall not be made without the Participant’s consent.

 

6.1.2       A
Participant may elect to receive his distribution upon separation from service in:

 

		6.1.2.1	A
                                         Lump sum payment, or

 

		6.1.2.2	If
                                         the vested portion of the Participant’s Account exceeds $5,000 (or such higher
                                         amount as may be permitted under applicable law or regulation), annual installments over
                                         a period not extending beyond five (5) years. While any annual installments remain unpaid,
                                         the value of the Participant’s Account shall continue to be adjusted to reflect
                                         any gains, losses, income and expenses of the Investment Fund. A Participant may elect,
                                         in the form and manner required by the Plan Administrator, to accelerate the payment
                                         of the Account and receive a single sum payment.

 

6.2          Distribution
Upon Death. A Participant’s Account shall be distributed to the Participant’s Beneficiary in a single cash
lump sum as soon as reasonably practicable after the Participant’s death. If a Participant dies without a Beneficiary designated
in accordance with Section 3.6, his Beneficiary shall be his surviving spouse, or otherwise, his estate.

 

6.3          Form
of Payment. Distributions pursuant to this Article 6 shall be paid in cash; provided that the Participant whose distribution
is in the form of a single sum may elect to receive the portion of his Account invested in the Employer Stock Fund in Shares,
which, except as otherwise provided in this Section 6.3, shall be electronically credited to an individual account established
for the benefit of the Participant, provided that if the Participant elects to receive physical share certificates, delivery shall
be made pursuant to the policies and procedures established by the Plan Administrator.

 

6.4          Direct
Rollover.

 

6.4.1       A
Participant may elect, at the time and in the manner prescribed by the Plan Administrator, to have any portion of an Eligible
Rollover Distribution paid directly to an Eligible Retirement Plan specified by the Participant.

 

6.4.2       A
Participant’s surviving spouse and the Participant’s spouse or former spouse who is the alternate payee under a qualified
domestic relations order, as defined in Section 206(d)(3)(B) of ERISA may make an election under this Section 6.4.

 

 

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ARTICLE
VII

WITHDRAWALS
DURING EMPLOYMENT

 

7.1          In
General.  Participants may withdraw the value of their Accounts during employment in accordance with the provisions
of this Article 7. The amounts withdrawn will be attributed to each of the Investment Funds on a pro rata basis.

 

7.2          Voluntary
Withdrawals.

 

7.2.1
      Regular Withdrawal Without Suspension. Subject to such rules as the Plan Administrator may from time to time prescribe,
an active Participant may make a withdrawal from his After-Tax Contributions Account and from his Prior Company Matching Contributions
Account up to two (2) times in any given Plan Year by filing a written notice with the Plan Administrator. Withdrawals shall be
made in the following order and classification:

 

7.2.1.1
   First, from the Participant’s After-Tax Contributions;

 

7.2.1.2
   Second, from the earnings on his After-Tax Contributions Account;

 

7.2.1.3
   Third, from the Participant’s Rollover Contributions;

 

7.2.1.4
   Fourth, from the earnings on his Rollover Contributions Account;

 

7.2.1.5    Fifth, from his Prior Company Matching Contributions Account; and

 

7.2.1.6
   Finally, from the earnings on his Prior Company Matching Contributions Account.

 

7.3          Withdrawal
of Pre-January 1, 1994 Contributions and Earnings.  In all cases, withdrawals from a Participant’s Account
shall be made strictly in the following order: first, from the balance as of December 31, 1993; second, from the balance as of
March 31, 1998; and lastly, from the contributions and earnings made after March 31, 1998.

 

7.4          Hardship
Withdrawals. An active Participant who has a hardship (as defined below) may make a withdrawal from his Pre-Tax Contributions
Account, subject to such rules as the Plan Administrator may from time to time prescribe and subject to the following terms and
conditions.

 

7.4.1       Withdrawals
From Other Accounts.  An active Participant who has a hardship may not make a withdrawal from his Pre-Tax Contributions
Account until all other available withdrawals under this Article 7 have been exhausted.

 

7.4.2.      Loans
from Other Plans. An active Participant who has a hardship may not make a withdrawal from his Pre-Tax Contributions Account
until he has taken all loans available in other qualified plans of which he is a participant, provided the taking of such loan
does not in and of itself cause a hardship.

 

 

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7.4.3       A
“hardship” shall mean the need for funds to meet the costs of:

 

7.4.3.1    Medical or dental expenses described in PR Code Section 1033.15(a)(4), to the extent not covered by insurance or reimbursed or
reimbursable by the Employer, for the Participant or his dependents (as defined in PR Code Section 1033.18(c)(1)(A)) incurred
during the current or immediately prior calendar year.

 

7.4.3.2    The purchase of a principal residence for the Participant, including related expenses incurred up to three (3) months following
the purchase but excluding mortgage payments.

 

7.4.3.3    Payment of tuition and related educational costs and fees (not reimbursable under any Employer’s tuition reimbursement program)
for the next twelve (12) months of post-secondary education for the Participant or his spouse or dependents (as defined in
PR Code Section 1033.18(c)(1)(A)).

 

7.4.3.4    Funeral expenses for a member of a Participant’s deceased parent, spouse, children or dependents (as defined in PR Code
Section 1033.18(c)(1)(A)) so long as consistent with the PR Code.

 

7.4.3.5    Avoiding eviction from the Participant’s principal residence.

 

7.4.3.6    Such other circumstances or events as may be prescribed by the Puerto Rico Secretary of the Treasury or his delegate.

 

7.4.4       The
amount of the hardship withdrawal cannot exceed the amount required to meet the hardship.

 

 

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ARTICLE
VIII

ADMINISTRATION

 

8.1          Plan
Administrator.  GlaxoSmithKline shall be the administrator of the Plan for purposes of ERISA.

 

8.2          Named
Fiduciary.  GlaxoSmithKline shall be the named fiduciary responsible for administration of the Plan. GlaxoSmithKline
may, however, by or pursuant to a resolution of the Board of Directors, delegate to any person or entity any of its powers or
duties under the Plan. To the extent of any such delegation, the delegate shall become the named fiduciary responsible for administration
of the Plan (if the delegate is a fiduciary by reason of the delegation), and references to GlaxoSmithKline shall apply instead
to the delegate. Any action by GlaxoSmithKline assigning any of its responsibilities to specific persons who are all directors,
officers, or employees of the Company or GlaxoSmithKline shall not constitute delegation of GlaxoSmithKline’s responsibility
but rather shall be treated as the manner in which GlaxoSmithKline has determined internally to discharge such responsibility.

 

8.3          Rules
of Administration.  GlaxoSmithKline shall adopt such rules for administration of the Plan as it considers desirable,
provided they do not conflict with the Plan, and may construe the Plan, correct defects, supply omissions and reconcile inconsistencies
to the extent necessary to effectuate the Plan and such action shall be conclusive. In making any such determination or rule,
GlaxoSmithKline shall pursue uniform policies as from time to time established and shall not discriminate in favor of or against
any Participant. GlaxoSmithKline shall have the exclusive right to make any finding of fact necessary or appropriate for any purpose
under the Plan including, but not limited to, the determination of the eligibility for and the amount of any benefit payable under
the Plan. GlaxoSmithKline shall have the exclusive right to interpret the terms and provisions of the Plan and to determine any
and all questions arising under the Plan or in connection with the administration thereof, including, without limitation, the
right to remedy or resolve possible ambiguities, inconsistencies or omissions, by general rule or particular decision. GlaxoSmithKline
shall make, or cause to be made, all reports or other filings necessary to meet both the reporting and disclosure requirements
and other filing requirements of ERISA which are the responsibility of “plan administrators” under ERISA. To the extent
permitted by law, all findings of fact, determinations, interpretations, and decisions of GlaxoSmithKline shall be conclusive
and binding upon all persons having or claiming to have any interest or right under the Plan. Records of administration of the
Plan shall be kept, and Employees and their Beneficiaries may examine records pertaining directly to themselves.

 

8.4          Duties
and Powers of GlaxoSmithKline or its Designated Representative. In addition to the duties and powers described elsewhere
hereunder, GlaxoSmithKline or its designated representative shall have the following specific duties and powers:

 

8.4.1       To
retain such consultants, accountants and attorneys as GlaxoSmithKline or its designated representative deems necessary or desirable
to render statements, reports, and advice with respect to the Plan and to assist GlaxoSmithKline or its designated representative
in complying with all applicable rules and regulations affecting the Plan; any consultants, accountants and attorneys may be the
same as those retained by the GlaxoSmithKline;

 

8.4.2       To
decide appeals under this Article 8;

 

 

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8.4.3       To
enact uniform and nondiscriminatory rules and regulations to carry out the provisions of the Plan;

 

8.4.4       To
resolve questions or disputes relating to eligibility for benefits or the amount of benefits under the Plan;

 

8.4.5       To
interpret the provisions of the Plan;

 

8.4.6       To
determine whether any domestic relations order received by the Plan is a qualified domestic relations order as provided in section
414(p) of the Code;

 

8.4.7       To
evaluate administrative procedures;

 

8.4.8       To
review and determine the funding policy of the Plan, with the advice of such experts as GlaxoSmithKline or its designated representative
deems appropriate; and

 

8.4.9       To
delegate such duties and powers as GlaxoSmithKline or its designated representative shall determine from time to time to any person
or persons.

 

8.4.10     The
expenses incurred by GlaxoSmithKline or its designated representative in connection with the operation of the Plan, including,
but not limited to, the expenses incurred by reason of the engagement of professional assistants and consultants, shall be expenses
of the Plan and shall be payable from the Trust Fund at the direction of GlaxoSmithKline or its designated representative. GlaxoSmithKline
shall have the option, but not the obligation, to pay any such expenses, in whole or in part, and, by so doing, to relieve the
Trust Fund from the obligation of bearing such expenses. Payment of any such expenses by GlaxoSmithKline on one occasion shall
not bind GlaxoSmithKline to pay any similar expenses on any subsequent occasion.

 

8.5          Services
to the Plan.  GlaxoSmithKline may contract for legal, actuarial, investment advisory, medical, accounting, clerical
and other services to carry out the Plan. The costs of such services and other administrative expenses shall be paid by the Company
or, at the option of the Company, proportionately from the Investment Funds or the Employer Stock Fund.

 

8.6          Funding
Policy.  GlaxoSmithKline shall annually review and determine the funding policy of the Plan, with the advice
of such experts as GlaxoSmithKline deems appropriate.

 

8.7          Records
and Reports.  The Plan Administrator shall keep a record of all actions taken and shall keep all other books
of account, records, and other data that may be necessary for proper administration of the Plan and shall be responsible for supplying
all information and reports to the United States Internal Revenue Service, United States Department of Labor, Puerto Rico Department
of Labor, Puerto Rico Department of the Treasury, Participants, Beneficiaries and others as required by law.

 

 

    - 25 -

     

    

 

8.8          Claims
Procedure.  

 

8.8.1.
     Appeal Procedure. If the Plan Administrator denies, in whole or in part, a claim for benefits by a Participant or
his beneficiary, the Plan Administrator shall furnish notice of the denial to the claimant, setting forth:

 

8.8.1.1.
          The specific reasons for the denial;

 

8.8.1.2.
          Specific reference to the pertinent Plan provisions on which the denial is based;

 

8.8.1.3.
          A description of any additional information necessary for the claimant to perfect the claim and an explanation of why such information
is necessary; and

 

8.8.1.4.
          Appropriate information as to the steps to be taken if the claimant wishes to submit his claim for review.

 

Such
notice shall be forwarded to the claimant within 90 days of the Plan Administrator’s receipt of the claim; provided, however,
that in special circumstances the Plan Administrator may extend the response period for up to an additional 90 days, in which
event it shall notify the claimant in writing of the extension, and shall specify the reason or reasons for the extension.

 

8.8.2.
    Decision
on Appeal. Within 60 days of receipt of a notice of claim denial, a claimant or his duly authorized representative may petition
the Plan Administrator in writing for a full and fair review of the denial. The claimant or his duly authorized representative
shall have the opportunity to review pertinent documents and to submit issues and comments in writing to the Plan Administrator.
The Plan Administrator shall review the denial and shall communicate its decision and the reasons therefor to the claimant in
writing within 60 days of receipt of the petition; provided, however, that in special circumstances the Plan Administrator may
extend the response period for up to an additional 60 days, in which event it shall notify the claimant in writing prior to the
commencement of the extension. The appeals procedure set forth in this Section 8.8.2 shall be the exclusive means for contesting
a decision denying benefits under the Plan.

 

8.9          Indemnification.  Each
person who is an Employee or director of a the Company, a Participating Company or an Affiliated Company shall be indemnified
and held harmless by the GlaxoSmithKline against and with respect to all damages, losses, obligations, liabilities, liens, deficiencies,
costs and expenses, including without limitation, reasonable attorney’s fees and other costs incident to any suit, action,
investigation, claim or proceedings to which he may be a party by reason of his performance of administrative functions and duties
under the Plan, except in relation to matters as to which he shall be held liable for an act of gross negligence or willful misconduct
in the performance of his duties. The foregoing right to indemnification shall be in addition to such other rights as the person
may enjoy as a matter of law or by reason of insurance coverage of any kind. Rights granted hereunder shall be in addition to
and not in lieu of any rights to indemnification to which the person may be entitled pursuant to the by-laws of the Company, a
Participating Company or an Affiliated Company.

 

8.10        Notice
of Address and Missing Persons.  Each person entitled to benefits under the Plan must file with the Plan Administrator,
in writing, the person’s post-office address and each change of post-office address. Any communication, statement, or notice
addressed to such a person at the person’s latest reported post office address will be binding upon the person for all purposes
of the Plan and neither the Plan Administrator nor the Company, Trustee, nor any insurance company shall be obliged to search
for or ascertain the person’s whereabouts. In the event that such person cannot be located, the Plan Administrator may direct
that such benefit and all further benefits with respect to such person shall be discontinued, all liability for the payment thereof
shall terminate and the balance in such Participant’s Account shall be deemed a Forfeiture; provided, however, that in the
event of a subsequent reappearance of the Participant or Beneficiary prior to termination of the Plan, the benefits which were
due and payable and which such person missed shall be paid in a single sum and the future benefits due such person shall be reinstated
in full.

 

 

    - 26 -

     

    

 

8.11         Effect
of a Mistake.  In the event of a mistake or misstatement as to the eligibility, participation, or service of
any Participant, or the amount of payments made or to be made to a Participant or Beneficiary, the Plan Administrator shall, if
possible, cause to be withheld or accelerated or otherwise make adjustment of such amounts of payments as will in its sole judgment
result in the Participant or Beneficiary receiving the proper amount of payments under this Plan.

 

 

    - 27 -

     

    

 

ARTICLE
IX

MANAGEMENT
OF FUNDS

 

9.1           Trust
Agreement.  The funds of the Plan shall be held by one or more Trustees selected by GlaxoSmithKline and the
Company. Each Trustee shall have such powers as to investment, reinvestment, control and disbursement of the funds of the Plan
as GlaxoSmithKline and the Company shall approve and deem to be in accordance with the Plan. All rights which may accrue to any
person under the Plan shall be subject to all the terms and provisions of the Trust Agreements entered into with the Trustee(s).
GlaxoSmithKline and the Company may modify the Trust Agreement(s) in accordance with the terms of the Trust Agreement(s) from
time to time to accomplish the purposes of the Plan.

 

9.2           Contributions.  The
Employer shall make such contributions to the Trust Fund as are required by the provisions of the Plan, subject to the right of
the Company to amend, modify, or terminate the Plan.

 

9.3           Non-reversion.  The
Employer shall have no right, title, or interest in the contributions made to the Trust Fund, and no part of the Trust Fund shall
revert to the Employer, except that if a contribution is made to the Trust Fund by the Employer by a mistake of fact, then such
contribution may be returned to the Employer within one year after the payment of the contribution; and if any part or all of
a contribution is disallowed as a deduction under PR Code Section 1033.09 then to the extent such contribution is disallowed
as a deduction it may be returned to the Employer within one year after the disallowance.

 

9.4           Rights
in the Trust Fund.  Persons eligible for benefits under the Plan are entitled to look only to the Trust Fund
for the payment of such benefits and have no claim against the Employer, the Plan Administrator, or any other person. No person
has any right or interest in the Trust Fund except as expressly provided in the Plan.

 

 

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ARTICLE
X

AMENDMENT,
TERMINATION, AND MERGERS

 

10.1        Amendment.  The
Company shall have the right at any time to amend or modify the Plan. Any action to be taken by the Company under the Plan shall
be taken by the Company’s Board of Directors pursuant to a resolution adopted by the Board of Directors. The Company’s
right to amend or modify the Plan as aforesaid shall not require the assent, concurrence, or any other action by the Company notwithstanding
that such action by the Company may relate in whole or in part to persons in the employ of the Company. However, no such amendment
shall authorize or permit any part of the Trust Fund (other than such part as is required to pay taxes and administration expenses)
to be used for or diverted to purposes other than for the exclusive benefit of the Participants or their Beneficiaries or estates;
no such amendment shall cause any reduction in the amount credited to the account of any Participant or cause or permit any portion
of the Trust Fund to revert to or become the property of the Company; and no such amendment which affects the rights, duties or
responsibilities of the Trustee and Plan Administrator may be made without the Trustee’s and Plan Administrator’s
written consent. Any such amendment shall become effective as provided therein upon its execution. The Trustee shall not be required
to execute any such amendment unless the Trust provisions contained herein are a part of the Plan and the amendment affects the
duties of the Trustee hereunder.

 

For
purposes of this Section 10.1, a Plan amendment which has the effect of (1) eliminating or reducing an early retirement benefit
or a retirement-type subsidy, (2) eliminating an optional form of benefit (as provided in United States Treasury Regulations)
or (3) restricting, directly or indirectly, the benefit provided to any Participant prior to the amendment shall be treated as
reducing the amount credited to the account of a Participant except that an amendment described in clause (2) (other than an amendment
having an effect described in clause (1)) shall not be treated as reducing the amount credited to the Account of a Participant
to the extent so provided in United States Treasury Regulations.

 

10.2        Termination.  It
is the intention of the Company that this Plan will continue indefinitely. However, the Company shall have the right at any time
to terminate the Plan by delivering to the Trustee and Plan Administrator written notice of such termination. A complete discontinuance
of Employer’s contributions to the Plan shall be deemed to constitute a termination with respect to such Employer. Upon
any termination (full or partial) or complete discontinuance of contributions, all amounts credited to the affected Participants’
Accounts shall become 100% vested and shall not thereafter be subject to forfeiture, and all unallocated amounts shall be allocated
to the Accounts of all Participants in accordance with the provisions hereof. Upon such termination of the Plan, the Company,
by written notice to the Trustee and Plan Administrator, may direct either:

 

10.2.1     complete
distribution of the assets in the Trust Fund to the Participants, in cash or in kind; or

 

10.2.2     continuation
of the trust and Trust Fund, and the distribution of benefits at such time and in such manner as though the Plan had not been
terminated.

 

 

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10.3         Merger
or Consolidation.  This Plan and Trust may be merged or consolidated with, or its assets and/or liabilities
may be transferred to any other Plan and Trust only if the benefits which would be received by a Participant of this Plan, in
the event of a termination of the Plan immediately after such transfer, merger, or consolidation, are at least equal to the benefits
the Participant would have received if the Plan had terminated immediately before the transfer, merger or consolidation.

 

 

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ARTICLE
XI

PARTICIPATION
IN AND WITHDRAWAL

FROM
THE PLAN BY AN AFFILIATED COMPANY

 

11.1         Participation
in the Plan.  Any Affiliated Company that desires to participate with the Company hereunder, may elect, with
the consent of the Board of Directors, to become a party to the Plan and Trust Agreement by adopting the Plan for the benefit
of its employees, effective as of the date specified in such adoption.

 

11.2         Withdrawal
from the Plan.  Any Participating Company may withdraw from the Plan and Trust Agreement after giving 90 days’
notice to the Board of Directors.

 

 

    - 31 -

     

    

 

ARTICLE
XII

GENERAL
PROVISIONS

 

12.1        Source
of Benefits.  The provisions of the Plan shall not create any obligation or liability against the Employer or
the Trustee for the payment of any benefit under the Plan beyond the funds of the Plan available for such payment.

 

12.2        No
Employment Rights.  This Plan shall not be deemed to constitute a contract between the Employer and any Participant
or to be a consideration or an inducement for the employment of any Participant or Employee. Nothing contained in this Plan shall
be deemed to give any Participant or Employee the right to be retained in the service of the Employer or to interfere with the
right of the Employer to discharge any Participant or Employee at any time regardless of the effect which such discharge shall
have upon him as a Participant of this Plan.

 

12.3        Alienation.

 

12.3.1     Subject
to the exceptions provided below, no benefit which shall be payable out of the Trust Fund to any person (including a Participant
or his Beneficiary) shall be subject in any manner to anticipation, alienation, sale, transfer, assignment, pledge, encumbrance,
or charge, and any attempt to anticipate, alienate, sell, transfer, assign, pledge, encumber, or charge the same shall be void;
and no such benefit shall in any manner be liable for, or subject to, the debts, contracts, liabilities, engagements, or torts
of any such person, nor shall it be subject to attachment or legal process for or against such person, and the same shall not
be recognized by the Trustee, except to such extent as may be required by law.

 

12.3.2     This
provision shall not apply to the extent a Participant or Beneficiary is indebted to the Plan, for any reason, under any provision
of the Plan. At the time a distribution is to be made to or for a Participant’s or Beneficiary’s benefit, such proportion
of the amount distributed as shall equal such indebtedness shall be paid by the Trustee to the Trustee or the Plan Administrator,
at the direction of the Plan Administrator, to apply against or discharge such indebtedness. Prior to making a payment, however,
the Participant or Beneficiary must be given written notice by the Plan Administrator that such indebtedness is to be so paid
in whole or part from his Participant’s Account. If the Participant or Beneficiary does not agree that the indebtedness
is a valid claim against his vested Participant’s Account, he shall be entitled to a review of the validity of the claim
in accordance with procedures provided in Sections 8.8.1 and 8.8.2.

 

12.3.3     This
provision shall not apply to a “qualified domestic relations order,” as defined in ERISA Section 206(d)(3). The
Plan Administrator shall establish a written procedure to determine the qualified status of domestic relations orders and to administer
distributions under such qualified orders. Further, to the extent provided under a “qualified domestic relations order,”
a former spouse of a Participant shall be treated as the spouse or surviving spouse for all purposes under the Plan.

 

12.4        Distribution
Pursuant to a Qualified Domestic Relations Order. Notwithstanding any other provisions of this Plan to the contrary, all
or part of a Participant’s vested Account may be distributed to an alternate payee at any time as may be specified in a
qualified domestic relations order as defined in Section 206(d)(3)(B) of ERISA. A domestic relations order shall not fail to be
a qualified domestic relations order merely because it provides for the distribution of part or all of a Participant’s Account
before such Participant reaches his or her “earliest retirement age,” within the meaning of Section 206(d)(3)(E)(ii)
of ERISA.

 

 

    - 32 -

     

    

 

12.5         Withholding.
The Company and the Trustee shall have the right to withhold any and all state, local, and federal taxes which may be withheld
in accordance with applicable law.

 

12.6         Voting
Rights.  Voting rights with respect to all securities in the Employer Stock Fund shall be exercised by the Trustee
in accordance with instructions provided by the Participant. Fractional Shares shall not be voted. Voting rights with respect
to all securities in any other investment portfolio shall be exercised by the Participants.

 

12.7         Tender
Offers.  Following any tender or exchange offer for Shares, the decision to tender with respect to all such
securities shall be exercised by Participants. The Plan Administrator shall use its best efforts to provide each Participant with
communications and instruction forms for the tender of Shares allocated to the Participant’s Account. Shares for which no
instructions are received shall not be tendered. Assets received by a Trustee following a tender of Shares shall be held and invested
for the account of the Participant for whom such Shares were tendered, and shall be reinvested in Trustee’s discretion,
consistent with the purposes of the Plan.

 

12.8         Facility
of Payment.  If the Plan Administrator deems any person incapable, by reason of minority, illness, infirmity,
or other incapacity of receiving benefits to which he is entitled, it may direct that payment be made directly for the benefit
of such person or to any person selected by the Plan Administrator to disburse it, whose receipt shall be a complete acquittance
therefor. Such payments shall, to the extent thereof, discharge all liability of the Company, the Plan Administrator and the party
making the payment.

 

12.9         Applicability
of the Plan.  The provisions set forth herein, and as the same may be further amended from time to time hereafter,
except as otherwise specifically provided herein or required by law, shall apply only with respect to the benefits of those Participants
who perform work as Employees on or after the effective dates of such provisions.

 

12.10       Notice.
Notices required to be given by Participants pursuant to the terms of the Plan must be in writing; provided, however, that the
Company may approve, in lieu of written notice, alternative methods of notice, including utilization of interactive telephone
response systems.

 

12.11       Construction
of Plan.  Pursuant to the authority granted in Section 8.4, the Plan Administrator shall interpret the provisions
of the Plan and decide any dispute that may arise regarding the rights of Participants thereunder. Any such determinations shall
be uniformly applied to all persons similarly situated and shall be binding and conclusive upon all interested parties. This Plan
and Trust shall be construed and enforced according to ERISA and the laws of the Commonwealth of Puerto Rico, to the extent not
preempted by ERISA.

 

12.12       Gender
and Number.  Wherever any words are used herein the masculine, feminine or neuter gender, they shall be construed
as though they were also used in another gender in all cases where they would so apply, and whenever any words are used herein
in the singular or plural form, they shall be construed as though they were also used in the other form in all cases where they
would so apply.

 

 

    - 33 -

     

    

 

12.13       Headings.  The
headings and subheadings of the Plan have been inserted for convenience of reference and are to be ignored in any construction
of the provisions hereof.

 

12.14       Governmental
Approval.  It is the intention of the Company to obtain a determination from the Puerto Rico Treasury Department
that (i) the Plan, as in effect from time to time, meets the requirements of PR Code Section 1081.01(a), respectively, and
(ii) any contributions made by the Company under the Plan are deductible for income tax purposes under PR Code Section 1033.09

 

12.15       Uniformity.  All
provisions of this Plan shall be interpreted and applied in a uniform nondiscriminatory manner.

 

12.16       Severability.
If any provision of this Plan is determined to be void by any court of competent jurisdiction, the Plan shall continue to operate
and, for the purposes of the jurisdiction of that court only, shall be deemed not to include the provisions determined to be void.
Except where otherwise clearly indicated by context, the masculine shall include the feminine and the singular shall include the
plural, and vice-versa.

 

 

    - 34 -

     

    

 

APPENDIX
A

 

GSK
PUERTO RICO 401(K) PLAN 

Affiliated
Companies Participating in the Plan

 

			GlaxoSmithKline
                                         Consumer Healthcare, L.P.

 

			GlaxoSmithKline
                                         Puerto Rico Inc.

 

			ViiV
                                         Healthcare Company

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