Document:

EXHIBIT 10.16

                        AMENDED AND RESTATED AGREEMENT

     This Amended and Restated  Agreement  ("Agreement"),  dated March 19, 2004,
amends and  supersedes  the Letter  Agreement  dated  January 30,  2004,  by and
between Cytomedix, Inc. (the "Company") and Burnham Hill Partners ("BHP").

I.      Services to Be Rendered

BHP shall act as the Company's  placement  agent in connection  with the private
placement of $2.8 million of Series C  Convertible  Preferred  Stock  ("Series C
Stock")  and  warrants  (the  "Financing").  Of the total  amount of  securities
offered and sold in the  Financing,  $1.5  million  shall be offered and sold to
Ritchie Capital  Management  ("Ritchie") or an entity  "affiliated" with Ritchie
(as defined in Rule 12b-2 under the Securities  Exchange Act of 1934  ("Exchange
Act")).  The remaining $1.3 million shall be offered and sold only to individual
"accredited"  investors  (as defined in Rule 501 under the Exchange Act) who are
natural persons with high net worth. The Financing will involve a transaction or
transactions  exempt from  registration  under the  Securities  Act of 1933,  as
amended,  and in compliance  with the  applicable  laws and  regulations  of any
jurisdiction  in which the  securities  offered in the  Financing are offered or
sold.

In  connection  with this  Agreement,  BHP will  advise  the  Company  as to the
specific terms of the  securities to be offered in the  Financing,  consult with
the Company as to potential  purchasers  of the  securities to be offered in the
Financing,  assist in the preparation and  distribution of appropriate  offering
materials to be used in connection with the Financing, and arrange the Financing
at a price and on terms acceptable to the Company.  BHP shall not have the power
or  authority to bind the Company to any sale of the  securities  offered in the
Financing.  Only the  Company  shall have the  authority  to approve any sale or
transfer of any security to be offered in the Financing.

BHP shall be  permitted  to engage  the  services  of one or more  sub-placement
agents,  subject to the  Company's  approval  and  consent to the  sub-placement
agent(s) selected by BHP.

The rights,  duties and  obligations of BHP as contained in this Agreement shall
be limited only to the Financing as described  above.  BHP shall have no rights,
duties or  obligations  with  respect  to any other  offering  of the  Company's
securities, including,  specifically, (i) any exchange of Series C Stock for the
Company's existing preferred stock, or (ii) any offering of the Company's common
stock and/or rights to purchase the Company's common stock.

II. Compensation and Expense  Reimbursement

The Company  shall pay to BHP a cash fee equal to ten percent (10%) of the gross
proceeds received by the Company in connection with the Financing.

BHP or its assigns shall receive Placement Agent Warrants representing the right
to purchase  that number of shares of the  Company's  common  stock equal to ten
percent (10%) of the common shares  underlying the aggregate  number of Series C
Stock sold as a result of BHP's  services  as  placement  agent  hereunder.  The
Placement  Agent Warrants  shall be  exercisable at the conversion  price of the
Series C Stock and shall  expire  five (5) years  from the  issuance  date.  The
common stock to be issued upon exercise of the Placement  Agent  Warrants  shall
have standard  piggyback  registration  rights, a cashless  exercise  provision,
shall be  non-redeemable  and shall be  included in the  registration  statement
covering the common stock to be issued upon  conversion of the Series C Stock to
be issued in the Financing.

The Company shall  provide to BHP periodic  reimbursement  of all  out-of-pocket
expenses,  which  amount  shall not exceed  $10,000  without  the prior  written
approval of the Company.

III.    Notice

Notice given pursuant to any of the provisions of this Agreement  shall be given
in writing  and shall be sent by  recognized  overnight  courier  or  personally
delivered  (a) if to the Company,  to its office at 1523 Bowman  Road,  Suite A,
Little  Rock,  Arkansas,  72211.  (b) if to BHP, to its office at 570  Lexington
Avenue, New York, NY 10022. Attention: Jason Adelman, Managing Director.

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IV.     Confidentiality

Unless  otherwise  required by applicable law, no advice or opinion  rendered by
BHP,  whether  formal or informal,  may be  disclosed,  in whole or in part,  or
summarized,  excerpted  from or otherwise  referred to without its prior written
consent.  In addition and unless  otherwise  required by applicable law, BHP may
not be otherwise referred to without its prior written consent.

BHP agrees  that all  confidential  information  which it may now possess or may
obtain  relating to the business,  financial  condition,  results of operations,
business properties,  assets or liabilities,  or future prospects of the Company
may not be published,  disclosed or made accessible by it to any other person or
any entity at any time or used by it without the written consent of the Company;
provided, however, that the restrictions of this sentence shall not apply (a) as
may  otherwise be required by law, (b) as may be  necessary  or  appropriate  in
connection with this Agreement,  or (c) to the extent such information  shall be
or shall otherwise become publicly available.

V.      Term

     BHP's  engagement  under this Agreement  shall terminate the earlier of (i)
such  date  that the  Company  has  received  and  accepted  valid  subscription
agreements and funds representing commitments to invest at least $2.8 million in
the Financing as provided in Section I above,  or (ii) thirty (30) days from the
date of this Agreement.

VI.     Consulting Agreement

     In connection with the Company's  future  financing and marketing  efforts,
BHP agrees to serve as a  consultant  to the Company  for a six-month  term with
compensation  of $5,000 per month.  As further  compensation  for the consulting
services  provided by BHP,  BHP shall be  entitled  to warrants  granting it the
right to purchase  100,000  shares of the  Company's  common  stock at $1.00 per
share.

VII.    Indemnification

The Company shall  indemnify and hold harmless BHP, its  affiliates,  directors,
officers,  partners, agents and controlling persons (collectively,  "Indemnified
Persons")  from and against any and all losses,  claims,  damages or liabilities
(including  actions or proceedings in respect thereof)  (collectively  "Losses")
related  to or  arising  out of (A)  any  untrue  statement  or  alleged  untrue
statement of a material  fact  contained  in any  information  (whether  oral or
written) or documents,  including, without limitation, any information furnished
by the  Company  and made  available  directly  or through BHP to any offeree of
securities  involved in the  Financing or any of their  representatives,  or the
omission or the alleged  omission to state therein a material fact  necessary in
order  to make  the  statements  therein  not  misleading,  in the  light of the
circumstances under which they were made, or (B) otherwise related to or arising
out of the engagement pursuant to this Agreement.  The Company shall be entitled
to seek  reimbursement  of any indemnity  payments made hereunder if it is found
that the Losses resulted primarily from the bad faith or gross negligence of any
Indemnified  Person,  breach  of this  Agreement,  or any  Indemnified  Person's
failure to comply with any federal or state law.

The Company will  reimburse  each  Indemnified  Person for  reasonable  expenses
(including reasonable fees and disbursements of counsel) as they are incurred by
such  Indemnified  Person in  connection  with  investigating,  preparing for or
defending  any  action,  claim,  investigation,  inquiry,  arbitration  or other
proceeding ("Action") referred to above (or enforcing the Agreement).

The Company's  obligations hereunder shall be in addition to any rights that any
Indemnified  Person may have at common law or otherwise.  Solely for the purpose
of enforcing the  indemnification  provisions under this Agreement,  the Company
hereby consents to personal  jurisdiction  and to service and venue in any court
in which any claim seeking Losses covered by this  indemnification  provision is
brought by or against any Indemnified  Person. The Company  acknowledges that in

Amended and Rstated Agreement                                     March 19, 2004

                                     Page 2
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connection  with the engagement  pursuant to this Agreement you are acting as an
independent  contractor  with  duties  owing  solely  to the  Company.  BHP  AND
CYOTMEDIX  HEREBY  AGREE TO WAIVE ANY RIGHT TO TRIAL BY JURY WITH RESPECT TO ANY
CLAIM,  COUNTER-CLAIM  OR ACTION ARISING OUT OF THE ENGAGEMENT  PURSUANT TO THIS
AGREEMENT, BHP'S PERFORMANCE THEREOF OR THIS INDEMNIFICATION PROVISION.

These  indemnification  provisions shall apply to the engagement pursuant to the
Agreement  (including  related  activities  prior  to the date  hereof)  and any
modification thereof and shall remain in full force and effect regardless of the
completion or termination of BHP's engagement hereunder.

VIII.   Miscellaneous

BHP is a division of Pali Capital  Inc., a European  American  Investment  Group
Company.  This Agreement shall remain in full force and effect as to BHP and the
Company in the event that BHP becomes an independent  entity. In connection with
this  engagement,  BHP is acting as an independent  contractor with duties owing
solely to the Company.  Each of BHP and the Company  agrees that the other party
has no fiduciary  duty to it or its  stockholders,  officers and  directors as a
result of the engagement described in this Agreement. This Agreement,  including
the indemnification provisions provided in Section VI above, shall be under seal
and governed by and  construed in  accordance  with the laws of the State of New
York without regard to conflicts of law principles  thereof.  This Agreement may
not be  amended or  modified  except in  writing  signed by each of the  parties
hereto.

This Agreement  contains the entire agreement of the parties with respect to the
subject  matter  hereof  and  supersedes  and  takes  precedence  over all prior
agreements  or  understandings,  whether  oral or  written,  between BHP and the
Company.  The invalidity or  unenforceability of any provision of this Agreement
shall not affect the validity or  enforceability of any other provisions of this
Agreement, which shall remain in full force and effect.

Accepted and Agreed:

Burnham Hill Partners               Cytomedix, Inc.

By:                             By:
    ------------------------        -------------------------
    Name:                           Name:
    Title:                          Title:

Amended and Rstated Agreement                                     March 19, 2004

                                     Page 3
<PAGE>Exhibit 4.17

                               Services Agreement

         This Services Agreement (the "Agreement") made and entered into this
___ day of October 2003 (the "Effective Date") by and between Cytomedix, Inc.
("Company"), a Delaware corporation, 1523 South Bowman Road, Suite A, Little
Rock, AR 72211, and Stern & Co., 50 Rockefeller Plaza, Suite 1038, New York, NY
10020 (the "Consultant").

         WHEREAS the Consultant desires to assist the Company in locating
potential investors to invest in the Company's debt and equity securities during
the Term of this Agreement and identifying market makers who would possibly be
interested in making a market in the Company's common stock ("Services", as
further described in Section 2 hereof);

         WHEREAS, the Company desires the Consultant to perform the Services;

         NOW, THEREFORE, in consideration of the mutual promises contained
herein, the parties agree as follows:

         1. Term. The Consultant shall provide Services to commence on the
Effective Date and continuing until December 31, 2004 (the "Term"), unless
sooner terminated pursuant to the provisions of Section 10 of this Agreement.

         2.       Services Rendered.

                  a. During the Term of this Agreement, the Consultant hereby
agrees to provide Services to the Company by locating potential investors in the
Company's debt and equity securities. The Services provided by Consultant shall
be limited to those of a finder and shall not include services customarily
performed by a broker-dealer. As a "finder", the Consultant (i) shall bring
together the Company and investors; (ii) shall not negotiate raising of capital
transactions; (iii) shall not directly solicit purchasers of the Company's
securities; (iv) shall not hold any funds or securities in a capital raising
transaction; (v) may not bind either party to a transaction; (vi) may introduce
the Company to broker-dealers without registering as a broker-dealer; (vii) may
only distribute offering materials or pre-offering materials to prospective
offerees where a substantial and pre-existing relationship establishing
"sophisticated" or "accredited investor" status is in place; and (viii) may give
the investor information about the Company, but not about the Company's
securities. The compensation due to Consultant is not based on a specified
percentage of any actual or proposed funds raised. Consultant further agrees not
to engage in any form of general solicitation or advertising as such terms are
defined by Rule 502(c) of Regulation D promulgated under the Securities Act of
1933.

                  b. During the Term, the Consultant shall be reasonably and
fully accessible to the Company during normal business hours and provide
Services as reasonably requested by the Company. The Consultant shall have the
right to perform services to parties other than the Company; provided, however,
that the Consultant shall not provide services to any other person or entity
which competes with the Company's business. The Consultant acknowledges that it
is obligated by this Agreement to perform the Services for the Company during
the Term of this Agreement without any compensation in addition to that
described in Section 4 hereof.

<PAGE>

         3. Oversight. The Consultant shall provide Services to the Company and
shall work directly with the Company's management; provided, however, that the
Consultant shall be supervised by and shall report directly to Ms. Nadine Smith
or such other representative so designated by the Company's Board of Directors.

         4. Compensation. As compensation for providing the Services to the
Company, the Consultant will receive warrants, upon the approval by the
Company's Board of Directors of a resolution authorizing the issuance of such
warrants, representing the right to purchase an aggregate of one hundred
thousand (100,000) shares of common stock (the "Warrants") exercisable pursuant
to Schedule A attached hereto and incorporated herein. Consultant shall have
registration rights for the shares of common stock issued upon exercise of the
Warrants as provided in the Registration Rights Agreement attached hereto as
Exhibit B and incorporated herein.

         5. Expenses. The Company will reimburse Consultant for reasonable
out-of-pocket expenses the Consultant incurs in connection with providing
Services only if Consultant has received prior written approval from the Company
of said expenses.

         6. Status. The Consultant is an independent contractor, and not an
agent, employee, or partner of the Company or any of its affiliates for any
purpose whatsoever. The Consultant will have no authority to, and agrees not to,
assume or create any obligation or liability, express or implied, on behalf of
the Company or any of its affiliates, or bind the Company or any of its
affiliates in any manner or to anything whatsoever. Except as otherwise provided
herein, the Consultant agrees to be liable for and to pay its own expenses.

         7. Representation. The Consultant hereby represents and warrants to the
Company that its execution, delivery and performance of this Agreement, and the
consummation of the transactions contemplated hereby does not and will not
conflict with, contravene or result in a violation or breach of or default under
(with or without the giving of notice or the lapse of time or both), any
contract, agreement or understanding to which the Consultant is a party or by
which the Consultant is or may be bound, including without limitation, any
non-competition or similar agreement. The Company acknowledges that it has been
given notice by Consultant that Consultant is not a licensed securities
broker-dealer and that Consultant therefore is not required under this Agreement
or any oral or written side agreement to sell securities on behalf of the
Company or any issuer affiliated with the Company. Moreover, the Company
acknowledges that Consultant does not intend to negotiate raising of capital
transactions, does not intend to directly solicit purchasers of the Company's
common stock, and will not hold any funds or securities in a capital raising
transaction; the compensation due to Consultant is not based on a specified
percentage of any actual or proposed funds raised. The parties specifically
acknowledge that Consultant has advised the Company that it is not a duly
licensed securities broker-dealer or member investment banking firm, that
Consultant does not act as a placement agent or underwriter for securities,
and/or that Consultant does not sell any securities. The Company acknowledges
that Consultant has informed it that neither Consultant nor any of its members
or employees provides any legal advice or counsel. Consultant's duties shall not
include auditing, valuation, accounting, computer network design or appraisal
services, all of which shall be procured by the Company at its own expense.

<PAGE>

         8. Confidential Information. The Consultant agrees that all matters
concerning the Company, any affiliate of the Company, or any business partner of
the Company will be treated by the Consultant as Confidential Information and
held in strict confidence both during and after the Term. "Confidential
Information" means all information relating to the Company's business or
operations, including but not limited to, client and supplier lists, data,
marketing plans, projections, strategies, unpublished financial information,
trade secrets, or discoveries. The provisions of this Section 8 shall survive
the termination or expiration of this Agreement.

         9. Termination.

                  (a) The Consultant or the Company may terminate this Agreement
due to a material breach hereof after written notice of the alleged breach to
the other party and a fifteen (15) day opportunity to cure has been given. If
the breach is not cured, the termination becomes effective on the date the cure
period has ended.

                  (b) In the event of termination, the Company shall pay the
Consultant for the expense reimbursement due and payable through the date of
termination.

         10. Execution of Agreement. The Consultant agrees to be bound by the
terms of this Agreement upon its execution of this Agreement and acknowledges
that the Company shall be bound by the terms of this Agreement only upon its
execution of this Agreement after the approval of a resolution authorizing the
Company to enter into this Agreement by the Board of Directors of the Company.

         11. Miscellaneous. This Agreement contains the entire agreement between
the Consultant and the Company concerning the subject matter hereof. No
amendment, modification or discharge of this Agreement, and no waiver hereunder,
shall be valid or binding unless set forth in writing and signed by both
parties. This Agreement shall be governed by and construed in accordance with
the laws of the State of Arkansas, without giving effect to its conflict of laws
principles or rules to the extent that the application of the law of another
jurisdiction would be required thereby.

         12. Counterparts; Headings. This Agreement may be executed in several
counterparts, each of which shall be deemed an original and all of which shall
together constitute one and the same instrument. The headings contained in this
Agreement are for purposes of convenience only and shall not affect the meaning
or interpretation of this Agreement.

<PAGE>

         IN WITNESS WHEREOF, the parties have executed this Agreement as of the
Effective Date.

CYTOMEDIX, INC.                             STERN & CO.

By:      ______________________________     By:_____________________________
Kent T. Smith, Chief Executive Officer         Shai Z. Stern, ______________

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