Document:

Amendment No. 2 to Rights Agreement

 Exhibit 4.1 
 AMENDMENT NO. 2 TO RIGHTS AGREEMENT 
 This Amendment No. 2 to Rights Agreement (this
“Amendment”), dated as of October 11, 2006, between ICOS Corporation, a Washington corporation (the “Company”), and Mellon Investor Services LLC, a New Jersey limited liability company, as Rights
Agent (the “Rights Agent”), amends that certain Rights Agreement, dated as of August 9, 2002 (the “Rights Agreement”), as amended by Amendment No. 1 to Rights Agreement dated
September 26, 2005. 
 The Company and the Rights Agent have heretofore executed and entered into the Rights Agreement. Pursuant to
Section 26 of the Rights Agreement, the Company and the Rights Agent may from time to time supplement or amend the Rights Agreement in accordance with the provisions of Section 26 thereof and the Company desires and directs the Rights
Agent to so amend the Rights Agreement. All acts and things necessary to make this Amendment a valid agreement according to its terms have been done and performed, and the execution and delivery of this Amendment by the Company and the Rights Agent
have been in all respects authorized by the Company and the Rights Agent. 
 In consideration of the foregoing premises and mutual agreements
set forth in the Rights Agreement and this Amendment, the parties hereto agree as follows: 
 1. Section 1 of the Rights Agreement is
hereby amended by adding as the final sentence to the definition of “Acquiring Person” the following: 
 “Notwithstanding the
foregoing, for purposes of this Rights Agreement, Eli Lilly and Company, an Indiana corporation (“Parent”), or any Affiliate or Associate thereof, including Tour Merger Sub, Inc., a Delaware corporation and wholly-owned
subsidiary of Parent (“Merger Sub”), shall not be deemed an “Acquiring Person” as a result of (i) the approval, execution or delivery of that certain Agreement and Plan of Merger dated as of October 11,
2006 (as the same may be amended from time to time, the “Merger Agreement”), by and among the Company, Parent and Merger Sub, including the approval, execution and delivery of any amendments thereto, (ii) the
consummation of the Merger (as such term is defined in the Merger Agreement), (iii) the acceptance for payment and purchase or exchange of Common Shares pursuant to the Merger Agreement, (iv) the announcement of the Merger Agreement or the
Merger (as such term is defined in the Merger Agreement) or (v) the consummation of any other transaction contemplated by the Merger Agreement.” 
 2. Section 1 of the Rights Agreement is further amended by adding as the final sentence to the definition of “Distribution Date” the following: 
 “Notwithstanding anything in this Rights Agreement to the contrary, no Distribution Date shall be deemed to have occurred as a result of (i) the
approval, execution or delivery of the Merger Agreement, including the approval, execution and delivery of any amendments thereto, (ii) the consummation of the Merger (as such term is defined in the Merger Agreement), (iii) the acceptance
for payment and purchase or exchange of Common Shares pursuant to the Merger Agreement, 

 (iv) the announcement of the Merger Agreement or the Merger (as such term is defined in the Merger
Agreement) or (v) the consummation of any other transaction contemplated by the Merger Agreement.” 
 3. Section 1 of the
Rights Agreement is further amended by adding as the final sentence to the definition of “Shares Acquisition Date” the following: 
 “Notwithstanding anything in this Rights Agreement to the contrary, no Shares Acquisition Date shall be deemed to have occurred as a result of (i) the approval, execution or delivery of the Merger Agreement, including the
approval, execution and delivery of any amendments thereto, (ii) the consummation of the Merger (as such term is defined in the Merger Agreement), (iii) the acceptance for payment and purchase or exchange of Common Shares pursuant to the
Merger Agreement, (iv) the announcement of the Merger Agreement or the Merger (as such term is defined in the Merger Agreement) or (v) the consummation of any other transaction contemplated by the Merger Agreement.” 
 4. Section 3(b) of the Rights Agreement is hereby amended by adding as the final sentence thereto the following: 
 “Notwithstanding anything in this Rights Agreement to the contrary, no Distribution Date shall be deemed to have occurred as a result of (i) the
approval, execution or delivery of the Merger Agreement, including the approval, execution and delivery of any amendments thereto, (ii) the consummation of the Merger (as such term is defined in the Merger Agreement), (iii) the acceptance
for payment and purchase or exchange of Common Shares pursuant to the Merger Agreement, (iv) the announcement of the Merger Agreement or the Merger (as such term is defined in the Merger Agreement) or (v) the consummation of any other
transaction contemplated by the Merger Agreement.” 
 5. Section 7(a) of the Rights Agreement is hereby deleted and replaced in its
entirety with the following: 
 “Subject to Section 7(e) and except as otherwise provided in this Rights Agreement (including
Section 11), each Right shall entitle the registered holder thereof, upon exercise thereof as provided in this Rights Agreement, to purchase for the Purchase Price, at any time after the Distribution Date and at or prior to the earlier of
(i) the Close of Business on the 10th anniversary of the date of this Rights Agreement, (ii) immediately prior to the Effective Time of the Merger (as such terms are defined in the Merger Agreement) (together with the event set forth in
clause (i) above, the “Expiration Date”) and (iii) the Redemption Date, one one-hundredth (1/100) of a Preferred Share, subject to adjustment from time to time as provided in Sections 11 and l2.”

  

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 6. Section 11(a) of the Rights Agreement is hereby amended by adding as the final sentence thereto
the following: 
 “Notwithstanding the foregoing, Parent, or any Affiliate or Associate thereof, including Merger Sub, shall not be
deemed an “Acquiring Person” as a result of (i) the approval, execution or delivery of the Merger Agreement, including the approval, execution and delivery of any amendments thereto, (ii) the consummation of the Merger (as such
term is defined in the Merger Agreement), (iii) the acceptance for payment and purchase or exchange of Common Shares pursuant to the Merger Agreement, (iv) the announcement of the Merger Agreement or the Merger (as such term is defined in
the Merger Agreement) or (v) the consummation of any other transaction contemplated by the Merger Agreement.” 
 7.
Section 11(c)(i) of the Rights Agreement is hereby amended by adding as the final sentence thereto the following: 
 “Notwithstanding anything in this Rights Agreement to the contrary, none of the events described in clauses (A) through (C) of Section 11(c)(i) shall be deemed to have occurred solely as a result of (i) the
approval, execution or delivery of the Merger Agreement, including the approval, execution and delivery of any amendments thereto, (ii) the consummation of the Merger (as such term is defined in the Merger Agreement), (iii) the acceptance
for payment and purchase or exchange of Common Shares pursuant to the Merger Agreement, (iv) the announcement of the Merger Agreement or the Merger (as such term is defined in the Merger Agreement) or (v) the consummation of any other
transaction contemplated by the Merger Agreement.” 
 8. Section 14(b) of the Rights Agreement is hereby amended by adding as the
final sentence thereto the following: 
 “Notwithstanding anything in this Rights Agreement to the contrary, no Distribution Date shall
be deemed to have occurred and Parent shall not become an Acquiring Person solely as a result of (i) the approval, execution or delivery of the Merger Agreement, including the approval, execution and delivery of any amendments thereto,
(ii) the consummation of the Merger (as such term is defined in the Merger Agreement), (iii) the acceptance for payment and purchase or exchange of Common Shares pursuant to the Merger Agreement, (iv) the announcement of the Merger
Agreement or the Merger (as such term is defined in the Merger Agreement) or (v) the consummation of any other transaction contemplated by the Merger Agreement.” 
 9. A new Section 33 shall be added and shall read as follows: 
 “Section 33. TERMINATION. Immediately prior to the Effective Time (as such term is defined in the Merger Agreement), this Rights Agreement shall be terminated and all outstanding Rights shall expire.”

  

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 10. The term “Rights Agreement” as used in the Rights Agreement shall be deemed to refer to the
Rights Agreement, as amended hereby. Except as expressly amended hereby, the Rights Agreement remains in full force and effect in accordance with its terms. 
 11. This Amendment shall be governed by and construed in accordance with the laws of the State of Washington; provided however, that all provisions regarding the rights, duties and obligations of the Rights Agent
shall be governed by and construed in accordance with the laws of the State of New York applicable to contracts made and to be performed entirely within such State. 
 12. This Amendment may be executed in any number of counterparts and each of such counterparts shall for all purposes be deemed an original, and all such counterparts shall together constitute but one and the same
instrument. 
 13. Except as expressly set forth herein, this Amendment shall not by implication or otherwise alter, modify, amend or in any
way affect any of the terms, conditions, obligations, covenants or agreements contained in the Rights Agreement, all of which are ratified and affirmed in all respects and shall continue in full force and effect. 
 14. Capitalized terms used herein but not defined shall have the meanings given to them in the Rights Agreement. 
 15. If any term, provision, covenant or restriction of this Agreement is held by a court of competent jurisdiction or other authority to be invalid, void
or unenforceable, the remainder of the terms, provisions, covenants and restrictions of this Amendment shall remain in full force and effect and shall in no way be affected, impaired or invalidated. 
  

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 IN WITNESS WHEREOF, the parties hereto have caused this Amendment to the Rights Agreement to be duly
executed as of the day and year first above written. 
  

			
	ICOS CORPORATION
		
	By:	 	 /s/ John B. Kliewer

	Name:	 	John B. Kliewer
	Title:	 	Vice President, General Counsel and Secretary
	
	 MELLON INVESTOR SERVICES, LLC,
 as Rights
Agent

		
	By:	 	 /s/ Thomas L. Cooper

	Name:	 	Thomas L. Cooper
	Title:	 	Client Relationship Executive

  

 5CMGI FY2007 Executive Management Incentive Plan

 Exhibit 10.1 
 CMGI 
 FY 2007 Executive Management Incentive Plan 
  

	1.	Purpose 

 The objective of the FY 2007
Executive Management Incentive Plan (“2007 EMIP Plan” or “Plan”) is to recognize and reward the achievement of financial, business and management goals that are essential to the success of CMGI, Inc. and its subsidiaries (the
“Company” or “CMGI”). 
  

	2.	Period of Effectiveness 

 This Plan relates
to the 2007 fiscal year, August 1, 2006 to July 31, 2007. 
  

	3.	Eligibility 

 Certain executive employees of
CMGI and its subsidiaries, as determined by the Human Resources and Compensation Committee of the Board of Directors of CMGI (the “Committee”), are eligible for participation in the 2007 EMIP Plan. (Each such designated person is called a
“Participant” in this Plan.) 
 CMGI will issue all Participants a notice of their eligibility and their individual Plan components
by providing a document in the form of Appendix B to each eligible Participant. Other eligibility requirements are listed in Section 9 below. 
  

	4.	Target Payout 

 Participants will be assigned
a target payout for the 2007 EMIP Plan, expressed as a percentage of base salary. This percentage (the “Target Payout”) represents the potential dollar award that will be earned at full achievement of goals for all Plan components. The
Target Payout will vary according to the Participant’s position. Actual payout will vary based on individual performance and Company performance, as set forth below. 
  

	5.	Plan Components and Targets 

 The Plan payout
will be measured based upon achievement against “NGOI” (regional and/or corporate, depending on the Participant’s role) and Individual Performance, as further described below. A percentage of each Participant’s Target Payout will
be allocated to each of the relevant components for that Participant. 
  

	 	A.	Non-GAAP Operating Income (Loss) (“NGOI”) 

 Non-GAAP Operating Income (Loss) (“NGOI”) is defined as Operating Income (Loss) of CMGI, Inc., excluding depreciation, amortization of intangibles, stock based compensation, long-lived asset impairment and restructuring charges,
and exclusive of the effects of @Ventures operations. 

 Each Participant’s target payout will include a component based on corporate NGOI targets. Some
Participants will also have a component based on a regional NGOI target. Each Participant will be informed of the relevant “Base Target” for corporate NGOI and, if applicable, for regional NGOI for the Participant’s region. For
corporate NGOI, an “Over-Achievement Target” will also be established 
  

	 	B.	Individual Performance 

 Each Participant’s
target payout will include a component based on achievement of individual goals and objectives. In order to be eligible for the individual performance component, all Participants must have clearly documented individual goals and objectives
established in conjunction with and approved by the Chief Executive Officer (and in the case of the Chief Executive Officer, by the Committee). Achievement of these goals and objectives will be assessed by the Chief Executive Officer following the
close of the fiscal year. 
  

	6.	Gates 

 If CMGI does not achieve the Base
Target for corporate NGOI, no payments whatsoever will be made under this Plan, whether for NGOI achievement (corporate or regional) or for individual performance. 
 No payout will be made without approval from the Committee. 
  

	7.	Calculation of Achievement and Overachievement Adjustments 

  

	 	A.	Corporate NGOI 

 In the event that the relevant Base
Target for corporate NGOI is achieved, each Participant would be eligible to receive full payment of the corporate NGOI component of his or her Target Payout. If the corporate NGOI exceeds the Base Target, the total payout made to the Participant
for corporate NGOI will be based on a pro rata sliding scale running between 100% and 200% based on the spread between the Base Target and the Overachievement Target. 
  

	 	B.	Regional NGOI 

 If the relevant Base Target for
regional NGOI is achieved, that Participant would be eligible to receive full payment of the regional NGOI component (if any) of his or her Target Payout. There is also a possibility to be paid greater than 100% of the portion of the Target Payout
allocated to regional NGOI achievement, in the event of regional NGOI results in excess of the Base Target. Any overachievement payment for regional NGOI will be based entirely on the Committee’s discretion. 
  

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	 	C.	Individual Performance 

 For the individual
performance metric, the Chief Executive Officer (and in the case of the Chief Executive Officer, the Committee) will assess each Participant’s performance against pre-established goals and assign a percentage achievement for the Individual
Performance Component. In the event the Company realizes overachievement with regard to corporate NGOI, the actual payment made with respect to individual performance will be increased proportionally to the amount of overachievement
paid with respect to corporate NGOI. 
  

	8.	Payout Calculations 

  

	 	A.	Each Participant’s EMIP payout percentage will be determined following the end of the 2007 fiscal year based upon achievement of the relevant targets applicable to the
Participant. Once the percentage of total salary due to the Participant is determined, the actual amount paid will be based on that percentage of the employee’s annual salary rate as of April 30, 2007. If the employee was not eligible for
EMIP for the full fiscal year, the payout will be pro-rated for the number of full months the employee was eligible in FY 2007. 

  

	 	B.	Results exceeding the maximum will be eligible for additional payouts at the discretion of the Board. 

  

	 	C.	The payments will be made in accordance with the Company’s normal payroll practices. 

  

	9.	Specific Eligibility Requirements 

  

	 	A.	To be eligible for any payment under the Plan, a Participant must be an active executive of CMGI or one of its subsidiaries (subject to Section 9B below) on the date actual
Plan payments are made. 

  

	 	B.	Only those employees who become eligible prior to April 30, 2007 will participate in the Plan. 

  

	 	C.	Employees who transfer into or out of an eligible position during the year and who are still employed as of the payment date, will be considered for a pro rata award under this
Plan. 

  

	10.	Administration of Plan; Miscellaneous Matters 

  

	 	A.	Payment on any particular occasion of any bonus amount in accordance with this Plan shall not create the presumption that any further bonus amount will be paid to the Participant
thereafter under this Plan or otherwise. 

  

	 	B.	Participants who live and work in a non-United States location will have their Plan payout calculations performed (i.e., comparisons against metrics will be local currency
denominated) and payouts issued in their local currency, unless a specific ex-patriate or other employment agreement specifically provides otherwise. 

  

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	 	C.	The adoption of this Plan shall not be deemed to give any employee the right to be retained in the employ of CMGI or its subsidiaries or to interfere with the right of the Company
to dismiss any employee at any time, for any reason not prohibited by law nor shall it be deemed to give the Company the right to require any employee to remain in its employ. 

  

	 	D.	Payments under this Plan are not to be considered for any purpose as part of the Participant’s base salary or wages. 

  

	 	E.	The financial targets assigned and recognized as goals on any of the performance factors may be removed, revised or otherwise modified by the Committee at any time for any reason or
for no reason. 

  

	 	F.	The Committee’s interpretation of the plan is final and in the sole and absolute discretion of the Committee. The Committee reserves the right to make final and binding
decisions regarding the amount of incentive, if any, to be paid to any Participant. The Committee also reserves the right to amend, terminate and modify this plan at any time in its sole discretion with or without notice. Each Participant, by
signing a Certificate of Acknowledgment, specifically acknowledges this right. 

  

	 	G.	No Participant or third party acting on behalf of or through a Participant shall have any power or right to transfer, assign, anticipate, hypothecate, mortgage, commute, modify or
otherwise encumber in advance any amounts that may be payable hereunder, nor shall any of said amounts be subject to seizure for payment of debt, judgments, alimony or separate maintenance owed by a Participant, or be transferable by operation of
law in the event of a bankruptcy, or otherwise. 

  

	 	H.	This Plan is administered by, and all decisions regarding any payments hereunder shall be made from, CMGI, Inc. regardless of whether a Participant is employed by CMGI or one of its
subsidiaries. 

  

	 	I.	If any term or condition of this plan is found to be in non-conformance with a given state or federal or other law, that term or condition will be non-enforceable but will not
negate other terms and conditions of the plan. 

  

	 	J.	The Plan shall be governed by and construed in accordance with the laws of the Commonwealth of Massachusetts. 

  

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 Appendix A 
 Certificate of Acknowledgement 
 I,
                                        
    , hereby certify that I have read the CMGI FY 2007 Executive Management Incentive Plan. I understand and agree with the terms of the Plan and agree to be bound thereby. 
  

			
		
	  
 Participant Signature
	  	  
 Date

		
	  
 Printed Name
	  	
		
	  
 Witness Signature
	  	
		
	  
 Printed Name
	  	

  

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 Appendix B 
 FY 2007 Executive Management Incentive Plan 
 Participant Information Form 
 Participant Name:
                                        
                                        
                             
 Job Title:
                                        
     
 Target Bonus Percentage:
                                        
     
 The Target Payout is allocated as follows: 
 Corporate NGOI Achievement:                     % 
 Regional NGOI Achievement:                     % 

Individual Performance:                     % 

The relevant NGOI Targets for Participant are as follows: 
 Corporate NGOI 
 Base Achievement Target:
$                     
 Over-Achievement Target:
$                     
 Regional NGOI (if
applicable) 
 Region:                     

 Base Achievement Target: $                    

  

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