Document:

EX-10.8

 Exhibit 10.8 

ONCORUS, INC. 

EMPLOYMENT AGREEMENT 

This Employment Agreement (the “Agreement”), effective as of July 16, 2018 (the “Effective Date”), is made by
and among Oncorus, Inc., a Delaware corporation (the “Company”) and Ted T. Ashburn, M.D., Ph.D. (“Executive” and, together with the Company, the “Parties”). 

WHEREAS, the Company desires to assure itself of the services of Executive by engaging Executive to perform services as an
employee of the Company under the terms hereof; 
 WHEREAS, Executive desires to provide services to the Company on the terms herein
provided; and 
 NOW, THEREFORE, in consideration of the foregoing, and for other good and valuable consideration, including the
respective covenants and agreements set forth below, the receipt and sufficiency of which are hereby acknowledged, the Parties hereto agree as follows: 

1. Employment. 

(a) General. The Company shall employ upon the terms and conditions provided herein effective as of the Effective Date. 

(b) Position and Duties. Effective on the Effective Date (as defined below), Executive: (i) shall serve as the
Company’s President and Chief Executive Officer, with responsibilities, duties, and authority usual and customary for such position, subject to direction by the Company’s Board of Directors (the “Board”); (ii) shall report
directly to the Chairman of the Board; and (iii) agrees promptly and faithfully to comply with (i) all reasonable and lawful directions and requests of the Board or a designated Committee thereof; and (ii) all present and future
policies, of the Company. While serving as the CEO of the Company Executive shall serve on the Board of Directors of the Company. At the Company’s request, Executive shall serve the Company and/or its subsidiaries and affiliates in such other
capacities in addition to the foregoing as the Company shall designate, provided that such additional capacities are consistent with Executive’s position as the Company’s Chief Executive Officer. In the event that Executive serves in any
one or more of such additional capacities, Executive’s compensation shall not automatically be increased on account of such additional service beyond that specified in this Agreement. 

(c) Exclusivity. Except with the prior written approval of the Board (which may grant or withhold in its sole and absolute
discretion), Executive shall devote substantially all of his working time, attention, and energies to the business of the Company, except during any paid vacation or other excused absence periods. Nothing in this section prevents Executive from
(i) engaging in additional activities in connection with personal investments and community affairs, (ii) serving as a member of the board of directors of one (1) organization that is not a competitor of the Company and is approved by
the Board, and (iii) serving as an advisor, or as a member of an advisory board, to one (1) organization that is not a competitor of the Company and is approved by the Board; provided such activities do not individually or in the
aggregate interfere with the performance of Executive’s duties under this Agreement, violate the Company’s standards of conduct then in effect, or raise a conflict under the Company’s conflict of interest policies. 

 2. Term. The period of Executive’s employment under this Agreement
shall commence on the Effective Date which is expected to be July 8 (or such other date as mutually agreed by Company and Executive) and shall continue until Executive’s employment with the Company is terminated pursuant to Section 4
below. The phrase “Term of Employment” as used in this Agreement shall refer to the entire period of employment of Executive by the Company. 

3. Compensation and Related Matters. 

(a) Annual Base Salary. Executive shall receive a base salary at the rate of $33,333 per month ($400,000 on an annualized
basis) (as may be adjusted from time to time, the “Annual Base Salary”), subject to withholdings and deductions, which shall be paid to Executive in accordance with the customary payroll practices and procedures of the
Company. Such Annual Base Salary shall be reviewed by the Board from time to time and is subject to such adjustments as determined necessary or appropriate by the Board. 

(b) Annual Bonus. During his Term of Employment, Executive shall be eligible to receive a discretionary annual (calendar year)
bonus based on Executive’s achievement of performance objectives set by the Board, after consultation with the Executive, each year as well as overall Company and individual performance, such bonus to be targeted at thirty-five percent (35%) of
Executive’s Base Salary (the “Annual Bonus”). The actual bonus award may be greater than or less than 35% and may be zero. Executive must remain employed by the Company through the date of payment in order to remain eligible
for such Annual Bonus. Any bonus awarded will be paid on or before March 15 of the year following the year for which the bonus is awarded. 

(c) Signing Bonus. Executive shall be eligible to receive a bonus of $60,000 on September 1, 2018. Executive is also
eligible for a special IPO bonus of $75,000 on successful completion of an IPO on NASDAQ exchange by the end of 3Q 2020. In each case, any bonus payment is subject to payroll withholdings and deductions and Executive must be employed by the Company
through the date of payment in order to remain eligible for such Bonus. 
 (d) Benefits. Executive shall be eligible to
participate in such employee and executive benefit plans and programs as the Company may from time to time offer to provide to its executives, subject to the terms and conditions of such plans and programs. Notwithstanding the foregoing, nothing
herein is intended, or shall be construed, to require the Company to institute or continue any particular plan, program or benefits. While serving as an executive of the Company and on the Company’s Board, Executive shall be covered by the
Company’s Directors and Officers Liability Insurance. If the Company has entered into indemnification agreements with members of its Board of Directors, The Company will enter into the same form of indemnification agreement with Executive in
his capacity as a member of the Board. 
 (e) Business Expenses. The Company shall reimburse Executive for all reasonable,
documented, out-of-pocket travel and other business expenses incurred by Executive in the performance of Executive’s duties to the Company in accordance with the
Company’s applicable expense reimbursement policies and procedures as are in effect from time to time. 

 4. Stock Option. As soon as reasonably practicable following the
Effective Date, the Company shall recommend to the Board that it grant to Executive, under the Oncorus, Inc. 2016 Equity Incentive Plan (the “Plan”) and his Oncorus, Inc. 2016 Equity Incentive Plan Option Agreement (the”
Option Agreement”), an option to purchase 5,676,318 shares of the Company’s common stock or, at the election of Executive, a restricted stock award (the “Award”) having an exercise or purchase price per share equal
to fair market value on the date of grant, as determined by the Board in its sole discretion. If the award is a stock option, it shall be an “incentive stock option” within the meaning of Section 422 of the Internal Revenue Code of
1986, as amended (the “Code”) to the maximum extent permitted by applicable law. The Award shall vest and become exercisable with respect to 25% of the shares subject thereto on the first anniversary of the Effective Date and with
respect to 1/48th of the shares subject thereto on each monthly anniversary of the Effective Date thereafter, in each case, subject to Executive’s continued service to the Company through
each vesting date. The Award will be subject to all of the terms and conditions of the Plan and the Option Agreement to be entered into by the parties pursuant to which it is granted. 

5. Termination.

(a) At-Will Employment. The Company and Executive acknowledge that Executive’s
employment is and shall continue to be at-will, as defined under applicable law. This means that it is not for any specified period of time and can be terminated by Executive or by the Company at any time,
with or without advance notice, and for any or no particular reason or cause. This “at-will” nature of Executive’s employment shall remain unchanged during Executive’s tenure as an employee
and may not be changed, except in an express writing signed by Executive. If Executive’s employment terminates for any reason, Executive shall not be entitled to any payments, benefits, damages, award, or compensation other than as provided in
this Agreement. 
 (b) Notice of Termination. During the Term of Employment, any termination of Executive’s employment by
the Company or by Executive (other than by reason of death) shall be communicated by written notice (a “Notice of Termination”) from one Party hereto to the other Party hereto (i) indicating the specific termination provision
in this Agreement relied upon, if any, (ii) setting forth in reasonable detail the facts and circumstances claimed to provide a basis for termination of Executive’s employment under the provision so indicated, and (iii) specifying the
Date of Termination (as defined below). The failure by either the Company or Executive to set forth in the Notice of Termination all of the facts and circumstances which contribute to a showing of Cause (as defined below) or Good Reason (as defined
below) shall not waive any right of the Company or Executive hereunder or preclude the Company or Executive from asserting such fact or circumstance in enforcing their rights hereunder. 

(c) Termination Date. For purposes of this Agreement, “Date of Termination” shall mean the date of the
termination of Executive’s employment with the Company specified in a Notice of Termination. 
 (d) Deemed Resignation.
Upon termination of Executive’s employment for any reason, Executive shall be deemed to have resigned from all offices and board memberships, if any, then held with the Company or any of its affiliates, and, at the Company’s request,
Executive shall promptly execute such documents as are necessary or desirable to effectuate such resignations. 

 6. Consequences of Termination. 

(a) Payments of Accrued Obligations upon all Terminations of Employment. Upon a termination of Executive’s employment for
any reason, Executive (or Executive’s estate or legal representative, as applicable) shall be entitled to receive, on or before the date required by applicable law and in any case within thirty (30) days after Executive’s Date of
Termination): (i) any portion of Executive’s Annual Base Salary earned through Executive’s Date of Termination not theretofore paid, (ii) any expenses owed to Executive under Section 3(d) above, (iii) any accrued but unused
paid time-off owed to Executive, (and (iv) any amount arising from Executive’s participation in, or benefits under, any employee benefit plans, programs, or arrangements under Section 3(c)
above, which amounts shall be payable in accordance with the terms and conditions of such employee benefit plans, programs, or arrangements. Except as otherwise set forth in Section 6(b) below, the payments and benefits described in this
Section 6(a) shall be the only payments and benefits payable in the event of Executive’s termination of employment for any reason; provided that such amount may be reduced in lieu of Executive’s repayment obligation as described in
Section 6(c) if applicable. 
 (b) Severance Payments upon Termination without Cause or For Good Reason. If, during the
Term of Employment, Executive’s employment is terminated by the Company without Cause or Executive resigns for Good Reason, in addition to the payments and benefits described in Section 6(a) above, and subject to Executive’s delivery
to the Company of a waiver and release of claims agreement in a form approved by the Company that becomes effective and irrevocable in accordance with Section 11(d) hereof (a “Release”), Executive will also be eligible for the
following: 
 (i) Severance in amount equal to twelve (12) months of Executive’s Annual Base Salary as of
Executive’s Date of Termination, such payment to be made in a single cash lump sum as soon as administratively practicable following the date the Release becomes effective and irrevocable or as otherwise provided in Section 11(d) hereof;

 (ii) During the period commencing on the Date of Termination and ending twelve (12) months later or, if earlier, the date on
which Executive becomes eligible for comparable replacement coverage under a subsequent employer’s group health plan (in any case, the “COBRA Period”), subject to Executive’s valid election to continue healthcare coverage
under Section 4980B of the Internal Revenue Code of 1986, as amended (the “Code”) and the regulation thereunder, payment by the Company of one-hundred percent (100%) of the COBRA premiums
necessary to continue Employee’s and his covered dependents’ health insurance coverage in effect for himself (and his covered dependents) on the termination date; provided, however, that if (1) any plan pursuant to which such
benefits are provided is not, or ceases prior to the expiration of the continuation coverage period to be, exempt from the application of Section 409A under Treasury Regulation
Section 1.409A-1(a)(5), (2) the Company is otherwise unable to continue to cover Executive or Executive’s dependents under its group health plans, or (3) the Company cannot provide the benefit
without violating applicable law (including, without limitation, Section 2716 of the Public Health Service Act), then, in any such case, an amount equal to each remaining Company subsidy shall thereafter be paid to Executive in substantially
equal monthly installments over the COBRA Period (or remaining portion thereof); 

 (iii) Beginning in 2019, in the event termination occurs after the completion of the
sixth (6th) full month of the fiscal year in which the Date of Termination occurs, an additional severance payment of a pro-rata portion (calculated based
on the number of days Executive served hereunder during such fiscal year) of Executive’s Annual Bonus at target payable at the same time that bonuses are paid to other Company executives. 

(iv) Notwithstanding anything in the Plan to the contrary, if the Executive’s employment is terminated by the Company without
Cause or by Executive for Good Reason within twelve months following a Change in Control (as defined below), 100% of Executive’s unvested Award will vest. 

(c) No Other Severance. The provisions of this Section 6 shall supersede in their entirety any severance payment provisions
in any severance plan, policy, program, or other arrangement maintained by the Company. 
 (d) Company Property. Executive
hereby acknowledges and agrees that all Personal Property (as defined below) and equipment furnished to, or prepared by, Executive in the course of, or incident to, Executive’s employment, belongs to the Company and shall be promptly returned
to the Company upon termination of Executive’s employment (and will not be kept in Executive’s possession or delivered to anyone else). For purposes of this Agreement, “Personal Property” includes, without limitation, all
books, manuals, records, reports, notes, contracts, lists, blueprints, and other documents, or materials, or copies thereof (including computer files), keys, building card keys, company credit cards, telephone calling cards, computer hardware and
software, cellular and portable telephone equipment, personal digital assistant (PDA) devices, and all proprietary information relating to the business of the Company or its subsidiaries or affiliates. Following termination, Executive shall not
retain any written or other tangible material containing any proprietary information of the Company or its subsidiaries or affiliates. 

(e) No Requirement to Mitigate; Survival. Executive shall not be required to mitigate the amount of any payment provided for
under this Agreement by seeking other employment or in any other manner. Notwithstanding anything to the contrary in this Agreement, the termination of Executive’s employment shall not impair the rights or obligations of any Party. 

(f) Definition of Cause. For purposes hereof, “Cause” shall mean any one of the following:
(i) Executive’s violation of any applicable material law or regulation respecting the business of the Company; (ii) Executive’s commission of conduct constituting, a felony or a crime involving moral turpitude; (iii) any act
of dishonesty, fraud, or misrepresentation in relation to Executive’s duties to the Company which act is materially and demonstrably injurious to the Company; (iv) Executive’s repeated failure to perform in any material respect
Executive’s duties hereunder after fifteen (15) days’ notice and an opportunity to cure such failure and a reasonable opportunity to present to the Board Executive’s position regarding any dispute relating to the existence of
such failure (other than on account of disability); (v) Executive’s failure to attempt in good faith to implement a clear and reasonable directive from the Board or to comply with any of the Company’s policies and procedures which failure
is either material or occurs after written notice from the Board; (vi) any act of gross misconduct which is materially and demonstrably injurious to the Company; or (vii) Executive’s breach of fiduciary duty owed to the Company. 

 (g) Definition of Change in Control. For purposes hereof, “Change in
Control” shall have the meaning assigned to it in Section 13(e) of the Plan. 
 (h) Definition of Good Reason.
For purposes hereof, “Good Reason” shall mean any one of the following: (i) a material (greater than 10%) reduction by the Company of Executive’s Base Salary, except in the case of either an across the board reduction in
salaries or a reduction of four (4) months or less due to financial exigency; (ii) the material reduction of Executive’s duties and responsibilities as set forth herein, provided, however, that (i) elimination of
“President” from Executive’s title will not constitute such a reduction so long as he retains the title CEO; and (ii) the acquisition of the Company and subsequent conversion of the Company to a division or unit of the acquiring
company will not by itself result in a diminution of Executive’s position; (iii) the Company’s material breach of this Agreement, or (iv) the relocation of Executive’s principal place of employment that increases
Executive’s one-way commute by more than thirty-five (35) miles, provided, that, in each case, Executive will not be deemed to have Good Reason unless (i) Executive first provides the
Board with written notice of the condition giving rise to Good Reason within thirty (30) days of its initial occurrence, (ii) the Company or the successor company fails to cure such condition within thirty (30) days after receiving
such written notice (the “Cure Period”), and (iii) Executive’s resignation based on such Good Reason is effective within thirty (30) days after the expiration of the Cure Period. 

7. Assignment and Successors. The Company shall assign its rights and obligations under this Agreement to any successor to
all or substantially all of the business or the assets of the Company (by merger or otherwise). This Agreement shall be binding upon and inure to the benefit of the Company, Executive, and their respective successors, assigns, personnel, and legal
representatives, executors, administrators, heirs, distributees, devisees, and legatees, as applicable. None of Executive’s rights or obligations may be assigned or transferred by Executive, other than Executive’s rights to payments
hereunder, which may be transferred only by will, operation of law, or as otherwise provided herein. 
 8. Miscellaneous
Provisions. 
 (a) Non-Competition Agreement. Executive shall execute and
continue to abide by the Company’s standard form Employee Invention, Non-Disclosure, Non-Competition and Non-Solicitation
Agreement entered into at the time Executive commenced employment (the “Non-Competition Agreement”). 

(b) Governing Law. This Agreement shall be governed, construed, interpreted, and enforced in accordance with its express terms,
and otherwise in accordance with the substantive laws of the Commonwealth of Massachusetts, without giving effect to any principles of conflicts of law, whether of the Commonwealth of Massachusetts any other jurisdiction, and where applicable, the
laws of the United States, that would result in the application of the laws of any other jurisdiction. 

 (c) Validity. The invalidity or unenforceability of any provision or
provisions of this Agreement shall not affect the validity or enforceability of any other provision of this Agreement, which shall remain in full force and effect. 

(d) Counterparts. This Agreement may be executed in several counterparts, each of which shall be deemed to be an original, but
all of which together will constitute one and the same Agreement. Signatures delivered by facsimile shall be deemed effective for all purposes. 

(e) Entire Agreement. The terms of this Agreement, together with the Confidential Information Agreement, are intended by the
Parties to be the final expression of their agreement with respect to the employment of Executive by the Company and supersede all prior understandings and agreements, whether written or oral, regarding Executive’s service to the Company. The
Parties further intend that this Agreement, together with the Confidential Information Agreement, shall constitute the complete and exclusive statement of their terms and that no extrinsic evidence whatsoever may be introduced in any judicial,
administrative, or other legal proceeding to vary the terms of this Agreement. 
 (f) Amendments; Waivers. This Agreement may
not be modified, amended, or terminated except by an instrument in writing signed by Executive and a duly authorized representative of the Company. By an instrument in writing similarly executed, Executive or a duly authorized officer of the
Company, as applicable, may waive compliance by the other Party with any specifically identified provision of this Agreement that such other Party was or is obligated to comply with or perform; provided, however, that such waiver shall
not operate as a waiver of, or estoppel with respect to, any other or subsequent failure. No failure to exercise and no delay in exercising any right, remedy, or power hereunder shall preclude any other or further exercise of any other right,
remedy, or power provided herein or by law or in equity. 
 (g) Dispute Resolution. The parties recognize that litigation in
federal or state courts or before federal or state administrative agencies of disputes arising out of the Employee’s employment with the Company or out of this Agreement, or the Employee’s termination of employment or termination of this
Agreement, may not be in the best interests of either the Employee or the Company, and may result in unnecessary costs, delays, complexities, and uncertainty. The parties agree that any dispute between the parties arising out of or relating to the
negotiation, execution, performance or termination of this Agreement or the Employee’s employment, including, but not limited to, any claim arising out of this Agreement, claims under Title VII of the Civil Rights Act of 1964, as amended, the
Civil Rights Act of 1991, the Age Discrimination in Employment Act of 1967, the Americans with Disabilities Act of 1990, Section 1981 of the Civil Rights Act of 1966, as amended, the Family Medical Leave Act, the Employee Retirement Income
Security Act, and any similar federal, state or local law, statute, regulation, or any common law doctrine, whether that dispute arises during or after employment, shall be settled by binding arbitration with the American Arbitration Association in
accordance with the National Rules for the Resolution of Employment Disputes of the American Arbitration Association; provided however, that this dispute resolution provision shall not apply to any separate agreements between the parties that
do not themselves specify arbitration as an exclusive remedy. The location for the arbitration shall be the Boston, Massachusetts metropolitan area. Any award made by such panel shall be final, binding and conclusive on the parties for all
purposes, and judgment upon the award rendered by the arbitrators may be entered in any court having jurisdiction thereof. The 

 
arbitrators’ fees and expenses and all administrative fees and expenses associated with the filing of the arbitration shall be borne by the Company; provided however, that at
the Employee’s option, Employee may voluntarily pay up to one-half the costs and fees. The parties acknowledge and agree that their obligations to arbitrate under this Section survive the termination of
this Agreement and continue after the termination of the employment relationship between Employee and the Company. The parties each further agree that the arbitration provisions of this Agreement shall provide each party with its exclusive
remedy, and each party expressly waives any right it might have to seek redress in any other forum, except as otherwise expressly provided in this Agreement. By election arbitration as the means for final settlement of all claims, the parties
hereby waive their respective rights to, and agree not to, sue each other in any action in a Federal, State or local court with respect to such claims, but may seek to enforce in court an arbitration award rendered pursuant to this Agreement. The
parties specifically agree to waive their respective rights to a trial by jury, and further agree that no demand, request or motion will be made for trial by jury. 

(h) Enforcement. If any provision of this Agreement is held to be illegal, invalid, or unenforceable under present or future
laws, such provision shall be fully severable; this Agreement shall be construed and enforced as if such illegal, invalid, or unenforceable provision had never comprised a portion of this Agreement; and the remaining provisions of this Agreement
shall remain in full force and effect and shall not be affected by the illegal, invalid, or unenforceable provision or by its severance from this Agreement. Furthermore, in lieu of such illegal, invalid, or unenforceable provision there shall be
added automatically as part of this Agreement a provision as similar in terms to such illegal, invalid, or unenforceable provision as may be possible and be legal, valid, and enforceable. 

(i) Withholding. The Company shall be entitled to withhold from any amounts payable under this Agreement any federal, state,
local, or foreign withholding or other taxes or charges which the Company is required to withhold. The Company shall be entitled to rely on an opinion of counsel if any questions as to the amount or requirement of withholding shall arise. 

(j) Notices. Any notices required hereunder to be in writing shall be deemed effectively given: (a) upon personal delivery
to the party to be notified, (b) when sent by electronic mail if sent during normal business hours of the recipient, and if not, then on the next business day, (c) five (5) days after having been sent by registered or certified mail,
return receipt requested, postage prepaid, or (d) one (1) day after deposit with a nationally recognized overnight courier, specifying next day delivery, with written verification of receipt. All communications shall be sent to the Company at
its primary office location and to Employee at Employee’s address as listed on the Company payroll or to Employee’s Company-issued email address, or at such other address as the Company or Employee may designate by ten (10) days
advance written notice to the other. 
 9. Prior Employment. Executive represents and warrants that Executive’s
acceptance of employment with the Company has not breached, and the performance of Executive’s duties hereunder will not breach, any duty owed by Executive to any prior employer or other person. Executive further represents and warrants to the
Company that (a) the performance of Executive’s obligations hereunder will not violate any agreement between Executive and any other person, firm, organization, or other entity; (b) Executive is not bound by the terms of any agreement
with any previous employer or other party to refrain from competing, 

 
directly or indirectly, with the business of such previous employer or other party that would be violated by Executive entering into this Agreement and/or providing services to the Company
pursuant to the terms of this Agreement; and (c) Executive’s performance of Executive’s duties under this Agreement will not require Executive to, and Executive shall not, rely on in the performance of Executive’s duties or
disclose to the Company or any other person or entity or induce the Company in any way to use or rely on any trade secret or other confidential or proprietary information or material belonging to any previous employer of Executive. 

10. Golden Parachute Excise Tax. 

(a) Best Pay. Any provision of this Agreement to the contrary notwithstanding, if any payment or benefit Executive would receive
from the Company pursuant to this Agreement or otherwise (“Payment”) would (i) constitute a “parachute payment” within the meaning of Section 280G of the Code and (ii) but for this sentence, be subject to
the excise tax imposed by Section 4999 of the Code (the “Excise Tax”), then such Payment will be equal to the Reduced Amount (as defined below). The “Reduced Amount” will be either (A) the largest portion
of the Payment that would result in no portion of the Payment (after reduction) being subject to the Excise Tax or (B) the entire Payment, whichever amount after taking into account all applicable federal, state, and local employment taxes,
income taxes, and the Excise Tax (all computed at the highest applicable marginal rate, net of the maximum reduction in federal income taxes which could be obtained from a deduction of such state and local taxes, if applicable), results in
Executive’ s receipt, on an after-tax basis, of the greater economic benefit notwithstanding that all or some portion of the Payment may be subject to the Excise Tax. If a reduction in a Payment is
required pursuant to the preceding sentence and the Reduced Amount is determined pursuant to clause (A) of the preceding sentence, the reduction shall occur in the manner (the “Reduction Method”) that results in the greatest
economic benefit for Executive. If more than one method of reduction will result in the same economic benefit, the items so reduced will be reduced pro rata (the “Pro Rata Reduction Method”). Notwithstanding the foregoing, if the
Reduction Method or the Pro Rata Reduction Method would result in any portion of the Payment being subject to taxes pursuant to Section 409A (as defined below) that would not otherwise be subject to taxes pursuant to Section 409A, then the
Reduction Method and/or the Pro Rata Reduction Method, as the case may be, shall be modified so as to avoid the imposition of taxes pursuant to Section 409A as follows: (1) as a first priority, the modification shall preserve to the
greatest extent possible, the greatest economic benefit for Executive as determined on an after-tax basis; (2) as a second priority, Payments that are contingent on future events (e.g., being
terminated without cause), shall be reduced (or eliminated) before Payments that are not contingent on future events; and (3) as a third priority, Payments that are “deferred compensation” within the meaning of Section 409A shall
be reduced (or eliminated) before Payments that are not deferred compensation within the meaning of Section 409A. 
 (b)
Accounting or Law Firm. The accounting firm or law firm engaged by the Company for general tax purposes as of the day prior to the Change of Control will perform the calculations set forth in Section 10(a) above. If the firm so
engaged by the Company is serving as the accountant or auditor, or lawyer for the acquiring company, the Company will appoint a nationally recognized accounting or law firm to make the determinations required hereunder. The Company will bear all
expenses with respect to the determinations by such firm required to be made hereunder. The firm engaged to make the determinations hereunder will provide its 

 
calculations, together with detailed supporting documentation, to the Company within thirty (30) days before the consummation of a Change of Control (if requested at that time by the
Company) or such other time as requested by the Company. If the firm determines that no Excise Tax is payable with respect to a Payment, either before or after the application of the Reduced Amount, it will furnish the Company with documentation
reasonably acceptable to the Company that no Excise Tax will be imposed with respect to such Payment. Any good faith determinations of the firm made hereunder will be final, binding and conclusive upon the Company and Executive. 

11. Section 409A; Release. 

(a) General. The intent of the Parties is that the payments and benefits under this Agreement comply with or be exempt from
Section 409A of the Code and the Department of Treasury regulations and other interpretive guidance issued thereunder, including without limitation any such regulations or other guidance that may be issued after the Effective Date,
(“Section 409A”) and, accordingly, to the maximum extent permitted, this Agreement shall be interpreted to be exempt from or in compliance therewith. Notwithstanding anything herein to the contrary, in no event
shall the Company or its affiliates have any liability to Executive or to any other person in the event that the Agreement is no so exempt from or compliant with Section 409A. [Revised because it is too burdensome to require the company to
constantly monitor changes to 409A and commit to ongoing compliance] 
 (b) Separation from Service. Notwithstanding any
provision to the contrary in this Agreement: (i) no amount that constitutes “deferred compensation” under Section 409A shall be payable pursuant to Section 6(b) above unless the termination of Executive’s employment
constitutes a “separation from service” within the meaning of Section 1.409A-1(h) of the Department of Treasury Regulations (“Separation from Service”); (ii) for purposes of
Section 409A, Executive’s right to receive installment payments shall be treated as a right to receive a series of separate and distinct payments; and (iii) to the extent that any reimbursement of expenses or in-kind benefits constitutes “deferred compensation” under Section 409A, such reimbursement or benefit shall be provided no later than December
31st of the year following the year in which the expense was incurred. The amount of expenses reimbursed in one year shall not affect the amount eligible for reimbursement in any subsequent year.
The amount of any in-kind benefits provided in one year shall not affect the amount of in-kind benefits provided in any other year. 

(c) Specified Employee. Notwithstanding anything in this Agreement to the contrary, if Executive is deemed by the Company at the
time of Executive’s Separation from Service to be a “specified employee” for purposes of Section 409A, to the extent delayed commencement of any portion of the benefits to which Executive is entitled under this Agreement is
required in order to avoid a prohibited distribution under Section 409A, such portion of Executive’s benefits shall not be provided to Executive prior to the earlier of (i) the expiration of the six (6)-month period measured from the
date of Executive’s Separation from Service with the Company or (ii) the date of Executive’s death. Upon the first business day following the expiration of the applicable Section 409A period, all payments deferred pursuant to the
preceding sentence shall be paid in a lump sum to Executive (or Executive’s estate or beneficiaries), and any remaining payments due to Executive under this Agreement shall be paid as otherwise provided herein. 

 (d) Release. Notwithstanding anything to the contrary in this Agreement, to
the extent that any payments due under this Agreement as a result of Executive’s termination of employment are subject to Executive’s execution and delivery of a Release and if Executive fails to execute the Release on or prior to the
Release Expiration Date (as defined below) or timely revokes Executive’s acceptance of the Release thereafter, Executive shall not be entitled to any payments or benefits otherwise conditioned on the Release, and (iii) in any case where
Executive’s Date of Termination and the Release Expiration Date fall in two separate taxable years, any payments required to be made to Executive that are conditioned on the Release and are treated as nonqualified deferred compensation for
purposes of Section 409A shall be made in the later taxable year. For purposes of this Section 11(d), “Release Expiration Date” shall mean the date that is twenty-one (21) days
following the date upon which the Company timely delivers the Release to Executive, or, in the event that Executive’s termination of employment is “in connection with an exit incentive or other employment termination program” (as such
phrase is defined in the Age Discrimination in Employment Act of 1967), the date that is forty-five (45) days following such delivery date. To the extent that any payments of nonqualified deferred compensation (within the meaning of
Section 409A) due under this Agreement as a result of Executive’s termination of employment are delayed pursuant to this Section 11(d), such amounts shall be paid in a lump sum on the first payroll date following the date that
Executive executes and does not revoke the Release (and the applicable revocation period has expired) or, in the case of any payments subject to Section 11(d)(iii), on the first payroll period to occur in the subsequent taxable year, if later.

 12. Reimbursement of Fees. Company shall reimburse Executive for reasonable and documented fees and expenses of
counsel incurred in connection with the negotiation of this Agreement. 
 13. Employee Acknowledgement. Executive
acknowledges that Executive has read and understands this Agreement, is fully aware of its legal effect, has not acted in reliance upon any representations or promises made by the Company other than those contained in writing herein, and has entered
into this Agreement freely based on Executive’s own judgment. 
 [Signature Page Follows] 

 IN WITNESS WHEREOF, the Parties have duly executed this Agreement as of the date and year
first above written.     
  

			
	ONCORUS, INC.
		
	By:	 	 /s/ Mitchell H. Finer

	Name: Mitchell H. Finer, Ph.D.
	Title: President and CEO
	
	EXECUTIVE
		
	By:	 	 /s/ Ted T. Ashburn

	Name: Ted T. Ashburn, M.D., Ph.D.

 FIRST AMENDMENT TO 

EMPLOYMENT AGREEMENT 

FOR TED T. ASHBURN 
 This
FIRST AMENDMENT TO THE EMPLOYMENT AGREEMENT FOR TED T. ASHBURN, M.D., PH.D. (the
“Amendment”) is entered into this 14th day of November 2018, by and between Ted T. Ashburn, M.D., Ph.D. (the “Executive”) and ONCORUS, INC. (the
“Company”). 
 RECITALS 

A. The Company and the Executive have entered into that certain Employment Agreement dated as of July 16, 2018 (the
“Employment Agreement”); and 
 B. The Company and the Executive desire to amend the Employment Agreement as provided
in this Amendment. 
 AGREEMENT 

The parties agree to the following: 
 1.
Amendment to Section 4. Section 4 of the Employment Agreement is hereby amended to delete such provision in its entirety and to replace such provision with the following: 

“Stock Option Award. 

(a) As soon as reasonably practicable following the Effective Date, the Company shall recommend to the Board that it
grant to the Executive, under the Oncorus, Inc. 2016 Equity Incentive Plan, as the same may be amended from time to time (the “Plan”) and his Oncorus, Inc. 2016 Equity Incentive Plan Option Agreement (the” Option
Agreement”), an option to purchase 4,235,680 shares of the Company’s common stock or, at the election of the Executive, a restricted stock award (the “Award”) having an exercise or purchase price per share equal to
fair market value on the date of grant, as determined by the Board in its sole discretion. If the Award is a stock option, it shall be an “incentive stock option” within the meaning of Section 422 of the Internal Revenue Code of 1986,
as amended (the “Code”) to the maximum extent permitted by applicable law. The Award shall vest and, if applicable become exercisable with respect to 25% of the shares subject thereto on the first anniversary of the Effective Date
and with respect to 1/48th of the shares subject thereto on each monthly anniversary of the Effective Date thereafter, in each case, subject to the Executive’s continued service to the
Company through each vesting date. The Award will be subject to all of the terms and conditions of the Plan and the Option Agreement to be entered into by the parties pursuant to which it is granted. 

 2. No Other Amendments. Except as modified or amended in this Amendment, no other term
or provision of the Employment Agreement is amended or modified in any respect. The Employment Agreement, and this Amendment, set forth the entire understanding between the parties with regard to the subject matter hereof and supersedes any prior
oral discussions or written communications and agreements. This Amendment cannot be modified or amended except in writing signed by the Executive and an authorized officer of the Company. 

[Signature Page Follows] 

 The parties have executed this First Amendment to the Employment Agreement for Ted T.
Ashburn on the day and year first written above. 
  

			
	ONCORUS, INC.
		
	By:	 	 /s/ Mitchell H. Finer

	Name: Mitchell H. Finer, Ph.D.
	Title: Executive Chairman
	
	EXECUTIVE
		
	By:	 	 /s/ Ted T. Ashburn

	Name: Ted T. Ashburn, M.D., Ph.D.

 SECOND AMENDMENT TO 

EMPLOYMENT AGREEMENT 
 This
SECOND AMENDMENT TO EMPLOYMENT AGREEMENT (this “Amendment”) is entered into this sixth day of April 2020, by and between Ted T. Ashburn, M.D.,
Ph.D. (the “Executive”) and ONCORUS, INC. (the “Company”). 

RECITALS 

A. The Company and the Executive have entered into that certain Employment Agreement dated as of July 16, 2018, which was subsequently
amended on November 14, 2018 (the “Employment Agreement”); and 
 B. The Company and the Executive desire to
further amend the Employment Agreement as provided in this Amendment. 
 AGREEMENT 

The parties agree to the following: 

1.    Amendment to Subsection 3(c). The second sentence of Subsection 3(c) of the Employment Agreement is hereby
deleted in its entirety and replaced with the following: 
 “Executive is also eligible for a special IPO bonus of $75,000 on successful
completion of an IPO on NASDAQ exchange by September 30, 2021.” 
 2.    Amendment to Subsection 6(b)(iv).
Subsection 6(b)(iv) of the Employment Agreement is hereby deleted in its entirety and replaced with the following: 

“(iv)    Notwithstanding anything in the Plan to the contrary, if the Executive’s employment is terminated
by the Company without Cause or by the Executive for Good Reason within twelve (12) months following a Change in Control (as defined below), then the unvested portion of all equity awards held by the Executive shall be accelerated in full such
that 100% of such awards shall become vested and exercisable effective upon the termination of the Executive’s employment.” 

3.    No Other Amendments. Except as modified or amended in this Amendment, no other term or provision of the
Employment Agreement is amended or modified in any respect. The Employment Agreement, and this Amendment, set forth the entire understanding between the parties with regard to the subject matter hereof and supersedes any prior oral discussions or
written communications and agreements. This Amendment cannot be modified or amended except in writing signed by the Executive and an authorized officer of the Company. 

[Signature Page Follows] 

 The parties have executed this Second Amendment to Employment Agreement on the date first
written above. 
  

			
	ONCORUS, INC.
		
	By:	 	/s/ Mitchell H. Finer
	 Name:
 Title:
	 	 Mitchell H. Finer, Ph.D.
 Executive
Chairman

  
  

			
	EXECUTIVE
		
	By:	 	/s/ Ted T. Ashburn
		 	Ted T. Ashburn, M.D., Ph.D.EX-10.9

 Exhibit 10.9 
  

 
 July 25, 2019 

John P. McCabe, CPA, MBA 
      

     
 Dear John: 

On behalf of Oncorus, Inc., a Delaware corporation (the “Company”), I am pleased to offer you employment with the
Company. The purpose of this letter is to summarize the terms of your employment with the Company, should you accept our offer. If accepted, this letter shall be held in escrow by the parties and shall become effective immediately following your
last day of employment with your current employer: 
 1.    Position and Duties. You will be employed to
serve on a full-time basis as Chief Financial Officer with a start date of July 29, 2019. As Chief Financial Officer, you will report to the CEO and be responsible for duties as assigned by him and as needed by the Company. In return for the
compensation payments set forth in this letter, you agree to devote your full business time, best efforts, skill, knowledge, attention, and energies to the advancement of the Company’s business and interests and to the performance of your
duties and responsibilities as an employee of the Company and not to engage in any other business activities without prior approval from the Company. 

2.    Base Salary. Your base salary will be at the rate of $13,750 per semi-monthly pay period. Such base
salary will be subject to tax and other withholdings as required by law and may be adjusted from time to time in accordance with normal business practice and in the sole discretion of the Company. 

3.    Benefits. You may participate in any and all bonus and benefit programs that the Company establishes
and makes available to similarly situated employees from time to time, provided you are eligible under (and subject to all provisions of) the plan documents governing those programs. Subject to these programs, you will be eligible to receive a bonus
targeted at thirty- five percent (35%) of your annualized base salary (on a pro-rated basis if you are employed for less than a full year) based on criteria to be mutually agreed upon between you and the CEO.
Any bonus earned will be calculated and paid within thirty (30) days after the first meeting of Oncorus’ Compensation Committee each calendar year to which the bonus applies and shall be paid subject to required withholdings and
deductions. You must remain actively employed through and including December 31st of the bonus year and through the bonus payment date in order to earn a bonus. The Company, in its sole discretion, will determine the amount of bonus earned, if any.

 
No bonus is guaranteed. The bonus and benefit programs made available by the Company, and the rules, terms and conditions for participation in such benefit plans, may be changed by the Company at
any time without advance notice. You will be eligible for sick leave and unlimited vacation in accordance with the Company’s sick leave and vacation policies. You will be reimbursed for your business expenses in accordance with Company policy.

 4.    Equity. You were previously granted a non-qualified stock
option (the “Option”) under the Company’s 2016 Equity Incentive Plan (the “Plan”) for the purchase of an aggregate of 1,588,379 shares of common stock of the Company at a price per share equal to
the fair market value at the time of Board approval. The Option shall be subject to all terms, vesting schedules and other provisions set forth in the Plan and in a separate option agreement. You may be eligible to receive such future stock option
grants as the Board of Directors of the Company shall deem appropriate. 
 5.    Incentive/Retention
Bonus. Should you remain continuously employed until the closing of an Initial Public Offering before June 30, 2020 in which the Company raises gross proceeds equal to or in excess of $50,000,000, and you are an employee in good standing
(as determined by the Company in its sole discretion) at such time, you will be eligible to receive a retention bonus of an additional $50,000, less deductions required by law (the “IPO Incentive Bonus”). The IPO Incentive
Bonus will be paid on the first regularly scheduled payroll date post- close of the Initial Public Offering, and so if awarded will be paid no later than the first payroll period in July 2020. 

6.    Termination of Employment. The parties acknowledge that your employment relationship with the Company
is at-will. Either you or the Company may terminate your employment relationship at any time, with or without Cause. The provisions in this Section govern the amount of compensation, if any, to be provided to
you upon termination of employment and do not alter this at-will status. 

(a)    Termination by the Company Without Cause or by you With Good Reason. If your employment is terminated
by the Company without Cause or you terminate your employment for Good Reason, then you shall be entitled to the Accrued Obligations (as defined below). If you execute and allow to become effective (within 60 days following your termination without
Cause or resignation for Good Reason, or such shorter period as may be directed by the Company) a release of claims in a form approved by the Company (the “Release Agreement”), which will include a
non-competition clause substantially similar to the non-competition clause included in the Employee Confidential Information and Invention Assignment Agreement (the
“Invention and Non-Disclosure Agreement”) attached hereto as Exhibit A, and comply fully with your
obligations hereunder the Company will pay or provide you as severance: 
 (i)    an aggregate amount equivalent
to twelve (12) months of your then current base salary, less all applicable taxes and withholdings (the “Severance Pay”), which Severance Pay will be paid ratably in accordance with the Company’s regular payroll
practices beginning in the Company’s first regular payroll cycle after the Release Agreement becomes effective; provided, however, that if the 60th day referenced above occurs in the calendar year following the date of your termination (the
“Separation Date”), then the Severance Pay shall begin no earlier than January l of such subsequent calendar year; and 

 (ii)    if you timely elect continued coverage under COBRA for
yourself and your covered dependents under the Company’s group health plans following the Separation Date, and provided you timely execute, return, and do not revoke this fully signed and dated Agreement to the Company, and comply fully with
your obligations hereunder, then the Company will pay, as and when due to the insurance carrier or COBRA administrator (as applicable), that portion of your COBRA premiums it was paying prior to the Separation Date until the earliest of (A) twelve
(12) months following the Separation Date, (B) the expiration of your eligibility for the continuation coverage under COBRA, or (C) the date when you become eligible for substantially equivalent health insurance coverage in connection
with new employment or self-employment (the “COBRA Severance,” and such period from the termination date through the earliest of (A) through (C), the “COBRA Payment Period”). Notwithstanding the
foregoing, if at any time the Company determines, in its sole discretion, that the payment of the COBRA premiums would result in a violation of the nondiscrimination rules of Section 105(h)(2) of the Code or any statute or regulation of similar
effect (including but not limited to the 2010 Patient Protection and Affordable Care Act, as amended by the 2010 Health Care and Education Reconciliation Act), then all payments and obligations under this clause will cease. On the 60th day following
your Separation Date, provided that you have elected continued coverage under COBRA for yourself and your covered dependents under the Company’s group health plans before that date, the Company will make the first payment under this clause
equal to the aggregate amount of payments that the Company would have paid through such date had such payments commenced on the Separation Date through such 60th day, with the balance of the payments paid thereafter on the schedule described above.
If you become eligible for coverage under another employer’s group health plan or otherwise cease to be eligible for COBRA during the period provided in this clause, you must immediately notify the Company of such event, and all payments and
obligations under this clause will cease; and 
 (iii)    additionally, the vesting schedule for your outstanding
equity awards will be accelerated such that the portion of the equity award that would have vested in the twelve (12) month period following such termination shall become vested and exercisable on the Separation Date, provided
that you execute and do not revoke the Release Agreement (the “Equity Acceleration,” together with the Severance Pay and COBRA Severance the “Severance Benefits”). 

(b)    Termination without Cause or With
Good Reason Following a Change in Control. If your employment is terminated by the Company without Cause (as defined below and not due to death or Disability as defined in the Plan)
or you terminate your employment for Good Reason, provided that if such termination occurs within two months prior to or within twelve (12) months following a Change of Control (as defined in the Plan), then: (i) the Company shall pay or
provide you the severance described in Sections 6(a)(i) and 6(a)(ii) above, and (ii) the vesting and exercisability of all outstanding stock options and other stock awards that are held by you as of immediately prior to the separation date
shall be accelerated in full, provided that you execute and do not revoke the Release Agreement. 

(c)    Termination Due to Discontinuance of Business. Anything in this Agreement to the contrary
notwithstanding, in the event the Company’s business is discontinued because rendered impracticable by substantial financial losses, lack of funding, legal decisions, administrative rulings, declaration of war, dissolution, national or local
economic depression or 

 
crisis or any reasons beyond the control of the Company, then this Agreement shall terminate as of the day the Company determines to cease operation with the same force and effect as if such day
of the month were originally set as the termination date hereof. In the event this Agreement is terminated pursuant to this Section 6(c), you will not receive any of the Severance Benefits, or any other compensation or benefits, except that,
pursuant to the Company’s standard payroll policies, the Company shall pay to you the Accrued Obligations 

7.    Definitions. For purposes of this Agreement: 

(a)    “Accrued Obligations” means (i) your accrued but unpaid salary through the
Separation Date, (ii) any unreimbursed business expenses incurred by you payable in accordance with the Company’s standard expense reimbursement policies, and (iii) benefits owed to you under any qualified retirement plan or health
and welfare benefit plan in which you were a participant in accordance with applicable law and the provisions of such plan. 

(b)    “Good Reason” means the occurrence, without your prior written consent, of any of the
following events: (i) a material reduction in your authority, duties, or responsibilities; (ii) the relocation of the principal place at which you provide services to the Company by at least 50 miles and to a location such that your daily
commuting distance is increased; (iii) a material reduction of your base salary (other than in connection with, and in an amount substantially proportionate to, reductions made by the Company to the base salaries of other members of
management); or (iv) a material breach by the Company of its obligations under this offer letter. No resignation will be treated as a resignation for Good Reason unless (x) you have given written notice to the Company of your intention to
terminate your employment for Good Reason, describing the grounds for such action, no later than 90 days after the first occurrence of such circumstances, (y) you have provided the Company with at least 30 days in which to cure the
circumstances, and (z) if the Company is not successful in curing the circumstance s, you end your employment within 60 days following the cure period in (y). 

8.    Section 409A. 

(a)    Notwithstanding anything to the contrary herein, the following provisions apply to the extent severance
benefits provided herein are subject to Section 409A of the Internal Revenue Code (the “Code”) and the regulations and other guidance thereunder and any state law of similar effect (collectively
“Section 409A”). Severance Benefits shall not commence until you have a “separation from service” (as defined under Treasury Regulation
Section 1.409A-1(h), without regard to any alternative definition thereunder, a “separation from service”). Each installment of Severance Benefits is a separate “payment” for purposes
of Treas. Reg. Section 1.409A-2(b)(2)(i), and the Severance Benefits are intended to satisfy the exemptions from application of Section 409A provided under Treasury Regulations Sections 1.409A-1(b)(4), 1.409A-1(b)(5) and 1.409A-1(b)(9). However, if such exemptions are not available and you are, upon separation from
service, a “specified employee” for purposes of Section 409A, then, solely to the extent necessary to avoid adverse personal tax consequences under Section 409A, the timing of the severance payments shall be delayed until the
earlier of (i) six (6) months and one day after your separation from service, or (ii) your death. The parties acknowledge that the exemptions from application of Section 409A to Severance Benefits are fact specific, and any later
amendment of this Agreement to alter the timing, amount or conditions that will trigger payment of severance benefits may preclude the ability of Severance Benefits provided under this Agreement to qualify for an exemption. 

 (b)    It is intended that this Agreement shall comply with the
requirements of Section 409A, and any ambiguity contained herein shall be interpreted in such manner so as to avoid adverse personal tax consequences under Section 409A. Notwithstanding the foregoing, the Company shall in no event be
obligated to indemnify you for any taxes or interest that may be assessed by the Internal Revenue Service pursuant to Section 409A of the Code to payments made pursuant to this Agreement. 

9.    Invention and Non-Disclosure Agreement. As a condition of
employment, you will be required to execute an Invention and Non-Disclosure Agreement in the form attached as Exhibit A, which may be amended by the parties from time to time without regard to this Agreement.
The Invention and Non-Disclosure Agreement contains provisions that are intended by the parties to survive and shall survive termination of this Agreement. 

10.    No Conflict. You represent that you are not bound by any employment contract, restrictive covenant or
other restriction preventing (or that purports to prevent) you from entering into employment with or carrying out your responsibilities for the Company, or which is in any way inconsistent with the terms of this letter. You specifically warrant that
you are not subject to an employment agreement or restrictive covenant preventing full performance of your duties to the Company. You agree not to bring to the Company or use in the performance of your responsibilities at the Company any materials
or documents of a former employer that are not generally available to the public, unless you have obtained express written authorization from the former employer for their possession and use. You also agree to honor all obligations to former
employers during your employment with The Company. 
 11.    General Provisions. 

(a)    Immigration. Your offer is contingent upon your satisfying the eligibility requirements for employment
in the United States. 
 (b)    At-Will Employment. This letter
shall not be construed as an agreement, either expressed or implied, to employ you for any stated term, and shall in no way alter the Company’s policy of employment at will, under which both you and the Company remain free to terminate the
employment relationship, with or without cause, at any time, with or without notice. Although your job duties, title, compensation and benefits, as well as the Company’s personnel policies and procedures, may change from time to time, the “at-will” nature of your employment may only be changed by a written agreement signed by you and the Company’s Chief Executive Officer, which expressly states the intention to modify the at-will nature of your employment. Similarly, nothing in this letter shall be construed as an agreement, either express or implied, to pay you any compensation or grant you any benefit beyond the end of your
employment with the Company. 
 (c)    Personnel Policies. Your employment is subject to the Company’s
personnel policies and procedures as they may be interpreted, adopted, revised or deleted from time to time in the Company’s sole discretion. 

 (d)    Complete Agreement. This Agreement constitutes the
entire agreement between Executive and the Company with regard to the subject matter hereof. This Agreement is the complete, final, and exclusive embodiment of their agreement with regard to this subject matter and supersedes any prior oral
discussions or written communications and agreements. This Agreement is entered into without reliance on any promise or representation other than those expressly contained herein, and it cannot be modified or amended except in writing signed by
Executive and an authorized officer of the Company. The parties have entered into a separate Invention and Non-Disclosure Agreement and have entered or may enter into other agreements governing equity. Any
such separate agreements govern other aspects of the relationship between the parties, have or may have provisions that survive termination of your employment under this Agreement, may be amended or superseded by the parties without regard to this
Agreement and are enforceable according to their terms without regard to the enforcement provision of this Agreement. 

(e)    Choice of Law. The resolution of any disputes under this letter will be governed by the laws of the
Commonwealth of Massachusetts. 
 (f)    Dispute Resolution. The parties recognize that litigation in federal or
state courts or before federal or state administrative agencies of disputes arising out of your employment with the Company or out of this Agreement, or your termination of employment or termination of this Agreement, may not be in the best
interests of either you or the Company, and may result in unnecessary costs, delays, complexities, and uncertainty. The parties agree that any dispute between the parties arising out of or relating to the negotiation, execution, performance or
termination of this Agreement or your employment, including, but not limited to, any claim arising out of this Agreement, claims under Title VII of the Civil Rights Act of 1964, as amended, the Civil Rights Act of 1991, the Age Discrimination in
Employment Act of 1967, the Americans with Disabilities Act of 1990, Section 1981 of the Civil Rights Act of 1966, as amended, the Family Medical Leave Act, the Employee Retirement Income Security Act, and any similar federal, state or local
law, statute, regulation, or any common law doctrine, whether that dispute arises during or after employment, shall be settled by binding arbitration conducted before a single arbitrator by Judicial Arbitration and Mediation Services, Inc.
(“JAMS”) or its successor, under the then applicable JAMS rules; provided however, that this dispute resolution provision shall not apply to any separate agreements between the parties that do not
themselves specify arbitration as an exclusive remedy. The location for the arbitration shall be the Boston, Massachusetts metropolitan area. Any award made by such panel shall be final, binding and conclusive on the parties for all purposes, and
judgment upon the award rendered by the arbitrators may be entered in any court having jurisdiction thereof. The arbitrators’ fees and expenses and all administrative fees and expenses associated with the filing of the arbitration shall be
borne by the Company; provided however, that at your option, you may voluntarily pay up to one-half the costs and fees. The parties acknowledge and agree that their obligations to arbitrate under this
Section survive the termination of this Agreement and continue after the termination of the employment relationship between you and the Company. The parties each further agree that the arbitration provisions of this Agreement shall provide each
party with its exclusive remedy, and each party expressly waives any right it might have to seek redress in any other forum, except as otherwise expressly provided in this Agreement. By election arbitration as the means for final settlement
of all claims, the parties hereby waive their respective rights to, and agree not to, sue each other in any action in a Federal, State or local court with respect to such claims, but may seek to enforce in court an

 
arbitration award rendered pursuant to this Agreement. The parties specifically agree to waive their respective rights to a trial by jury, and further agree that no demand, request or motion
will be made for trial by jury. 
 If you agree with the provisions of this letter, please sign the enclosed duplicate of this letter in
the space provided below and return it to me by July 26, 2019. If you do not accept this offer by this date, the offer will be revoked. 
  

			
	 Very Truly Yours,
  

ONCORUS, INC.

		
	By:	 	/s/ Ted A. Ashburn
	 Name:
 Title:
	 	 Ted A. Ashburn
 Chief Executive
Officer

 The foregoing correctly sets forth the terms of my future employment by Oncorus, Inc. 

 

			
	Date: July 25, 2019	  	 /s/ John P. McCabe

		  	Name: John P. McCabe

 FIRST AMENDMENT TO 

OFFER LETTER 
 This
FIRST AMENDMENT TO OFFER LETTER (this “Amendment”) is entered into this sixth day of April 2020, by and between John P. McCabe (the
“Executive”) and ONCORUS, INC. (the “Company”). 

RECITALS 

A. The Company and the Executive have entered into that certain Offer Letter dated as of July 25, 2019 (the “Offer
Letter”); and 
 B. The Company and the Executive desire to amend the Offer Letter as provided in this Amendment. 

AGREEMENT 

The parties agree to the following: 

1.    Amendment to Section 5. The first sentence of Section 5 of the Offer
Letter is hereby deleted in its entirety and replaced with the following: 
 “Should you remain continuously employed until the closing
of an Initial Public Offering before September 30, 2021 in which the Company raises gross proceeds equal to or in excess of $50,000,000, and you are an employee in good standing (as determined by the Company in its sole discretion) at such
time, you will be eligible to receive a retention bonus of an additional $50,000, less deductions required by law (the “IPO Incentive Bonus”).” 

2.    No Other Amendments. Except as modified or amended in this Amendment, no other term or provision of the Offer
Letter is amended or modified in any respect. The Offer Letter and this Amendment set forth the entire understanding between the parties with regard to the subject matter hereof and supersedes any prior oral discussions or written communications and
agreements. This Amendment cannot be modified or amended except in writing signed by the Executive and an authorized officer of the Company. 

[Signature Page Follows] 

 The parties have executed this First Amendment to Offer Letter on the date first written
above. 
  

			
	ONCORUS, INC.
		
	By:	 	/s/ Ted T. Ashburn
	 Name:
 Title:
	 	 Ted T. Ashburn, M.D., Ph.D.
 Chief Executive
Officer

  
  

			
	EXECUTIVE
		
	By:	 	/s/ John P. McCabe
		 	John P. McCabe

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