Document:

EXHIBIT 4.1

                   LABORATORY CORPORATION OF AMERICA HOLDINGS
                 AMENDED AND RESTATED 1999 STOCK INCENTIVE PLAN

1.   Purpose; Restrictions on Amount Available under this Plan.

     This Amended and Restated 1999 Stock Incentive Plan (this "Plan") is
intended to encourage stock ownership by employees of Laboratory Corporation of
America Holdings (the "Company") and employees of Affiliate Corporations (as
defined in Section 2(a) hereof), so that they may acquire or increase their
proprietary interest in the Company, and to encourage such employees to remain
in the employ of the Company and to put forth maximum efforts for the success
of the business of the Company. It is further intended that options granted by
the Committee pursuant to Section 6 of this Plan shall constitute "incentive
stock options" ("Incentive Stock Options") within the meaning of Section 422 of
the Internal Revenue Code of 1986, as amended, and the regulations issued
thereunder (the "Code"), and options granted by the Committee pursuant to
Section 7 of this Plan shall constitute "nonqualified stock options"
("Nonqualified Stock Options"). Grants under this Plan may consist of Incentive
Stock Options, Nonqualified Stock Options (collectively, "Options"), stock
appreciation rights ("Rights"), which Rights may be either granted in
conjunction with Options ("Related Rights") or unaccompanied by Options ("Free
Standing Rights"), or restricted stock awards ("Restricted Shares"), as
hereinafter set forth.

2.   Definitions.

     As used in this Plan, the following words and phrases shall have the
meanings indicated:

          (a) "Affiliate Corporation" or "Affiliate" shall mean any
     corporation, directly or indirectly, through one or more intermediaries,
     controlling, controlled by, or under common control with the Company.

          (b) "Award" shall mean an Option, a Right or Restricted Share granted
     hereunder.

          (c) "Award Agreement" shall have the meaning set forth in Section 3
     hereof.

          (d) "Change in Control" shall mean circumstances under which Roche
     Holding Ltd or any corporation directly or indirectly, through one or more
     intermediaries, controlling, controlled by, or under common control with
     Roche Holding Ltd ceases to maintain "beneficial ownership" (as defined in
     Rule 13d-3 of the Exchange Act), individually or in the aggregate, of
     securities of the Company representing five percent (5%) or more of the
     combined voting power of the Company's then outstanding securities.

          (e) "Common Stock" shall mean shares of the Company's common stock,
     par value $0.01 per share.

          (f) "Disability" shall mean a Participant's inability to engage in
     any substantial gainful activity by reason of medically determinable
     physical or mental impairment that can be expected to result in death or
     that has lasted or can be expected to result in death or that has lasted
     or can be expected to last for a continuous period of not less than twelve
     (12) months.

          (g) "Exchange Act" shall mean the Securities Exchange Act of 1934, as
     amended.

          (h) "Fair Market Value" per share as of a particular date shall mean
     (i) the closing sales price per share of Common Stock on a national
     securities exchange for the last preceding date on which there was a sale
     of such Common Stock on such exchange, or (ii) if the shares of Common
     Stock are then traded on an over-the-counter market, the average of the
     closing bid and asked prices for the shares of Common Stock in such
     over-the-market for the last preceding date on which there was a sale of
     such Common Stock in such market, or (iii) if the shares of Common Stock
     are not then listed on a national securities exchange or traded in an
     over-the-counter market, such value as the Committee in its discretion may
     determine.

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          (i) "Parent Corporation" shall mean any corporation (other than the
     Company) in an unbroken chain of corporations ending with the Company if,
     at the time of granting an Award, each of such corporations (other than
     the Company) owns stock possessing fifty percent (50%) or more of the
     total combined voting power of all classes of stock in one of the other
     corporations in such chain.

          (j) "Participant" shall have the meaning set forth in Section 4
     hereof.

          (k) "Retirement" shall mean a Participant's termination of employment
     in accordance with the provisions of the Company's Employee Retirement
     Plan at such Participant's Normal Retirement Date, as defined in such
     plan.

          (l) "Subsidiary Corporation" shall mean any corporation (other than
     the Company) in an unbroken chain of corporations beginning with the
     Company if, at the time of granting an option, each of such corporations
     other than the last corporation in the unbroken chain owns stock
     possessing fifty percent (50%) or more of the total combined voting power
     of all classes of stock in one of the other corporations in such chain.

          (m) "Ten Percent Stockholder" shall mean a Participant who, at the
     time an Incentive Stock Option is granted, owns stock possessing more than
     ten percent (10%) of the total combined voting power of all classes of
     stock of the Company or of its Parent Corporation or Subsidiary
     Corporations.

3.   Administration.

     This Plan shall be administered by a committee (the "Committee") appointed
by the Board of Directors of the Company (the "Board"), which shall be
comprised of two or more persons, each of whom shall qualify as a "Non-Employee
Director" as described in Rule 16b-3(b)(3)(i) promulgated under the Exchange
Act.

     The Committee shall have the authority in its discretion, subject to and
not inconsistent with the express provisions of this Plan, to administer this
Plan and to exercise all the powers and authorities either specifically granted
to it under this Plan or necessary or advisable in the administration of this
Plan, including, without limitation, the authority to grant Awards; to
designate Participants; to determine the type or types of Awards to be granted
to a Participant; to determine which Options shall constitute Incentive Stock
Options and which Options shall constitute Nonqualified Stock Options; to
determine which Rights (if any) shall be granted in conjunction with Options;
to determine the purchase price of the shares of Common Stock covered by each
Option (the "Option Price"); to determine the persons to whom, and the time or
times at which, Awards shall be granted; to determine the number of shares to
be covered by each Award; to interpret this Plan; to prescribe, amend and
rescind rules and regulations relating to this Plan; to determine the terms and
provisions of the agreements (which need not be identical) entered into in
connection with Awards granted under this Plan (each an "Award Agreement"); and
to make all other determinations deemed necessary or advisable for the
administration of this Plan. The Committee may delegate to one or more of its
members or to one or more agents such administrative duties as may be deemed
advisable, and the Committee or any person to whom it has delegated duties as
aforesaid may employ one or more persons to render advice with respect to any
responsibility the Committee or such person may have under this Plan.

     No member of the Board of Directors or Committee shall be liable for any
action taken or determination made in good faith with respect to this Plan or
any Award granted hereunder.

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4.   Eligibility.

     Awards may be granted to key employees (including, without limitation,
officers and directors who are employees) of the Company or its present or
future Affiliate Corporations. For purposes of the foregoing, "employee" shall
mean any employee, independent contractor, consultant, advisor, or similar
individual who is providing or who has agreed to provide services to the
Company or to any of its present or future Affiliate Corporations.
Notwithstanding any provision of this paragraph, Incentive Stock Options shall
be granted only to individuals who, on the date of such grant, are employees of
the Company or a Parent Corporation or a Subsidiary Corporation. In determining
the persons to whom Awards shall be granted and the number of shares to be
covered by each Award, the Committee shall take into account the duties of the
respective persons, their present and potential contributions to the success of
the Company and such other factors as the Committee shall deem relevant in
connection with accomplishing the purpose of this Plan. A person to whom an
Award has been granted hereunder is sometimes referred to herein as a
"Participant."

     A Participant shall be eligible to receive more than one grant of an Award
during the term of this Plan, but only on the terms and subject to the
restrictions hereinafter set forth.

5.   Stock.

     The stock subject to Awards hereunder shall be shares of Common Stock.
Such shares may, in whole or in part, be authorized but unissued shares or
shares that shall have been or that may be reacquired by the Company. The
aggregate number of shares of Common Stock as to which Awards may be granted
from time to time under this Plan shall not exceed 9,200,000 of which the
number of shares of Common Stock as to which Restricted Shares may be granted
from time to time under this Plan shall not exceed 3,200,000. No person may be
granted Options or Rights under this Plan representing an aggregate of more
than 750,000 shares of Common Stock in any year. The limitations established by
the preceding three sentences shall be subject to adjustment as provided in
Section 11 hereof.

     To the extent that (1) any Award expires, is terminated or forfeited
without being exercised, settled or with respect to Restricted Shares, vested,
(2) any Option is surrendered on exercise of a Right for cash or the issuance
of fewer shares of Common Stock than issuable under such surrendered Option, or
(3) any Free Standing Right expires or is terminated without being exercised,
the shares of Common Stock issuable thereunder, less such shares issued, shall
become available for grants of Awards.

6.   Incentive Stock Options.

     Options granted pursuant to this Section 6 are intended to constitute
Incentive Stock Options and shall be subject to the following special terms and
conditions, in addition to the general terms and conditions specified in
Sections 5 and 8 hereof:

          (a) Value of Shares. The aggregate Fair Market Value (determined as
     of the date the Incentive Stock Option is granted) of the shares of Common
     Stock with respect to which Options granted under this Plan and all other
     option plans of the Company, any Parent Corporation and any Subsidiary
     Corporation become exercisable for the first time by a Participant during
     any calendar year shall not exceed $100,000.

          (b) Ten Percent Stockholders. In the case of an Incentive Stock
     Option granted to a Ten Percent Stockholder, (i) the Option Price shall
     not be less than one hundred ten percent (110%) of the Fair Market Value
     of a share of Common Stock of the Company on the date of grant of such
     Incentive Stock Option, and (ii) the exercise period shall not exceed five
     (5) years from the date of grant of such Incentive Stock Option.

7.   Nonqualified Stock Options.

     Options granted pursuant to this Section 7 are intended to constitute
Nonqualified Stock Options and shall be subject only to the general terms and
conditions specified in Sections 5 and 8 hereof.

8.   Terms and Conditions of Options.

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     Each Option granted pursuant to this Plan shall be evidenced by a written
Award Agreement between the Company and the Participant, which agreement shall
comply with and be subject to the following terms and conditions:

          (a) Number of Shares. Each Award Agreement shall state the number of
     shares of Common Stock to which the Option relates.

          (b) Type of Option. Each Award agreement shall specifically identify
     the portion, if any, of the Option which constitutes an Incentive Stock
     Option and the portion, if any, which constitutes a Nonqualified Stock
     Option.

          (c) Option Price. Each Award Agreement shall state the Option Price
     per share of Common Stock, which shall be not less than one hundred
     percent (100%) of the Fair Market Value of a share of Common Stock of the
     Company on the date of grant of the Option and which, in the case of
     Incentive Stock Options, shall be further subject to the limitation
     described in Section 6(b) hereof. The Option Price shall be subject to
     adjustment as provided in Section 11 hereof. The date on which the
     Committee adopts a resolution expressly granting an Option shall be
     considered the day on which such Option in granted.

          (d) Medium And Time of Payment. The Option Price shall be paid or
     satisfied in full, at the time of exercise, in cash or in shares of Common
     Stock owned by the Participant for at least six months (which are not the
     subject of any pledge or other security interest) having a Fair Market
     Value equal to such Option Price or in a combination of cash and such
     shares, and may be effected in whole or in part, at the discretion of the
     Committee (i) with monies received from the Company at the time of
     exercise as a compensatory cash payment, or (ii) with monies borrowed from
     the Company pursuant to repayment terms and conditions as shall be
     determined from time to time by the Committee, in its discretion
     separately with respect to each exercise of Options and each Participant;
     provided, however, that each such method and time for payment and each
     such borrowing and terms and conditions of security, if any, and repayment
     shall be permitted by and be in compliance with applicable law.

          (e) Term and Exercise of Options. Options shall be exercisable over
     the exercise period as and at the times and upon the conditions that the
     Committee may determine, as reflected in the Award Agreement; provided,
     however, that the Committee shall have the authority to accelerate the
     exercisability of any outstanding Option at such time and under such
     circumstances as it, in its sole discretion, deems appropriate. The
     exercise period shall be determined by the Committee; provided, however,
     that in the case of any Incentive Stock Option, such exercise period shall
     not exceed ten (10) years from the date of grant of such Incentive Stock
     Option and such exercise period shall be further limited in circumstances
     described in Section 6(b) hereof. The exercise period shall be subject to
     earlier termination as provided in Section 8(f) and 8(g) hereof. An Option
     may be exercised as to any or all full shares of Common Stock as to which
     the Option has become exercisable, by giving written notice of such
     exercise to the Committee; provided, however, that an Option may not be
     exercised at any one time as to fewer than one hundred (100) shares (or
     such number of shares as to which the Option is then exercisable if such
     number of shares is less than one hundred (100)).

          (f) Termination of Employment. Except as provided in this Section
     8(f) and in Section 8(g) hereof, an Option may not be exercised unless the
     Participant is then in the employ of (1) the Company, (2) an Affiliate
     Corporation or (3) a corporation issuing or assuming the Option in a
     transaction to which Section 424 of the Code applies or a parent
     corporation or subsidiary corporation of the corporation described in this
     Clause 3, and unless the Participant has remained continuously so employed
     since the date of grant of the Option. In the event that the employment of
     a Participant shall terminate (other than by reason of death, Disability
     or Retirement), all Options of such Participant that are exercisable at
     the time of such termination may, unless earlier terminated in accordance
     with their terms, be exercised within three (3) months after such
     termination. Nothing in this Plan or in any Option or Right granted
     pursuant hereto shall confer upon an individual any right to continue in
     the employ of the Company or any of its Affiliate Corporations or
     interfere in any way with the right of the Company or any such Affiliate
     Corporation to terminate such employment at any time.

          (g) Acceleration of Benefits upon Death, Disability or Retirement of
     Participant or a Change in Control. If (i) a Participant shall die while
     employed by the Company or an Affiliate Corporation thereof, (ii) a
     Participant shall die within three (3) months after the termination of
     such Participant's employment, (iii) the Participant's employment shall
     terminate by reason of Disability or Retirement, or (iv) there is a Change
     in Control, then in any

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     such case all Options theretofore granted to such Participant (whether or
     not then exercisable) may, unless earlier terminated or expired in
     accordance with their terms, be exercised by the Participant or by the
     Participant's estate or by a person who acquired the right to exercise
     such Option by bequest or inheritance or otherwise by reason of the death
     or Disability of the Participant, at any time within one year after the
     date of death, Disability or Retirement of the Participant or the Change
     in Control.

          (h) Nontransferability of Options. Options granted under this Plan
     shall not be transferable otherwise than by will or by the laws of descent
     and distribution, and Options may be exercised, during the lifetime of the
     Participant, only by the Participant or by his guardian or legal
     representative.

          (i) Rights as a Stockholder. A Participant who is the holder of an
     Option or a transferee of an Option shall have no rights as a stockholder
     with respect to any shares covered by the Option until the date of the
     issuance of a stock certificate to him or her for such shares. No
     adjustment shall be made for dividends (ordinary or extraordinary, whether
     in cash, securities or other property) or distribution of other rights for
     which the record date is prior to the date such stock certificate is
     issued, except as provided in Section 11 hereof.

          (j) Other Provisions. The Award Agreements authorized under this Plan
     shall contain such other provisions, including, without limitation, (i)
     the granting of Rights, (ii) the imposition of restrictions upon the
     exercise of an Award, and (iii) in the case of an Incentive Stock Option,
     the inclusion of any condition not inconsistent with such Option
     qualifying as an Incentive Stock Option, as the Committee shall deem
     advisable.

9.   Stock Appreciation Rights.

     (a) Grant and Exercise. In the case of a Nonqualified Stock Option,
Related Rights may be granted either at or after the time of the grant of such
Option. In the case of an Incentive Stock Option, related Rights may be granted
only at the time of the grant of the Incentive Stock Option.

     A Related Right or applicable portion thereof granted with respect to a
given Option shall terminate and no longer be exercisable upon the termination
or exercise of the related Option, except that, unless otherwise provided by
the Committee at the time of grant, a Related Right granted with respect to
less than the full number of shares covered by a related Option shall only be
reduced if and to the extent that the number of shares covered by the exercise
or termination of the related Option exceeds the number of shares not covered
by the Right.

     A Related Right may be exercised by a Participant, in accordance with
paragraph (b) of this Section 9, by surrendering the applicable portion of the
related Option. Upon such exercise and surrender, the Participant shall be
entitled to receive an amount determined in the manner prescribed in paragraph
(b) of this Section 9. Options which have been so surrendered, in whole or in
part, shall no longer be exercisable to the extent the Related Rights have been
exercised.

     (b) Terms and Conditions. Rights shall be subject to such terms and
conditions, not inconsistent with the provisions of this Plan, as shall be
determined from time to time by the Committee and as evidenced by a written
Award Agreement between the Company and the Participant, including the
following:

          (1) Related Rights shall be exercisable only at such time or times
     and to the extent that the Options to which they relate shall be
     exercisable in accordance with the provisions of Section 6, 7, 8 and this
     Section 9 of this Plan; provided, however, that any Related Right shall
     not be exercisable during the first six (6) months of the term of the
     Related Right, except that this additional limitation shall not apply in
     the event of death of the Participant prior to the expiration of the six
     (6) month period.

          (2) Upon the exercise of a Related Right, a Participant shall be
     entitled to receive up to, but not more than, an amount in cash or shares
     of Common Stock equal in value to the excess of the Fair Market Value of
     one (1) share of Common Stock over the option price per share specified in
     the related Option multiplied by the number of shares in respect of which
     the Related Right shall have been exercised, with the Committee having the
     right to determine the form of payment.

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          (3) Related Rights shall be transferable only when and to the extent
     that the underlying Option would be transferable under paragraph (h) of
     Section 8 of this Plan.

          (4) A Related Right granted in connection with an Incentive Stock
     Option may be exercised only if and when the market price of the Common
     Stock subject to the Incentive Stock Option exceeds the exercise price of
     such Option.

          (5) Free Standing Rights shall be exercisable at such time or times
     and subject to such terms and conditions as shall be determined by the
     Committee at or after grant; provided, however, that Free Standing Rights
     shall not be exercisable during the first (6) six months of the term of
     the Free Standing Right, except that this limitation shall not apply in
     the event of death of the recipient of the Free Standing Right prior to
     the expiration of the six-month period.

          (6) The term of each Free Standing Right shall be fixed by the
     Committee, but no Free Standing Right shall be exercisable more than ten
     (10) years after the date such right is granted.

          (7) Upon the exercise of a Free Standing Right, a Participant shall
     be entitled to receive up to, but not more than, an amount in cash or
     shares of Common Stock equal in value to the excess of the Fair Market
     Value of one share of Common Stock over the price per share specified in
     the Free Standing Right (which shall be no less than one hundred percent
     (100%) of the Fair Market Value of the Common Stock on the date of grant)
     multiplied by the number of shares in respect of which the Right is being
     exercised, with the Committee having the right to determine the form of
     payment.

          (8) No Free Standing Right shall be transferable by the Participant
     otherwise than by will or by the laws of descent and distribution, and all
     such rights shall be exercisable, during the Participant's lifetime, only
     by the Participant or his legal guardian or legal representative.

          (9) In the event of the termination of employment of a recipient of a
     Free Standing Right, such right shall be exercisable to the same extent
     that an Option would have been exercisable in the event of the termination
     of employment of a Participant.

10.  Restricted Shares.

     (a) Grant. Subject to the provisions of this Plan, the Committee shall
have sole and complete authority to determine the Participants to whom
Restricted Shares shall be granted, the number of Restricted Shares to be
granted to each Participant, the duration of the period during which, and the
conditions under which, the Restricted Shares may be forfeited to the Company,
and the other terms and conditions of such Awards.

     (b) Transfer Restrictions. Restricted Shares may not be sold, assigned,
transferred, pledged or otherwise encumbered, except as provided in an Award
Agreement. Certificates issued in respect of Restricted Shares shall be
registered in the name of the Participant and deposited by such Participant,
together with a stock power endorsed in blank, with the Company. Upon the lapse
of the restrictions applicable to such Restricted Shares, the Company shall
deliver such certificates to the Participant or the Participant's legal
representative.

     (c) Dividends and Distributions. Dividends and other distributions paid on
or in respect of Restricted Shares, if any, may be paid directly to the
Participant, or may be reinvested in additional Restricted Shares, as
determined by the Committee in its sole discretion.

     (d) Acceleration of Benefits upon Death, Disability or Retirement of
Participant or a Change in Control. If (i) a Participant shall die while
employed by the Company or an Affiliate Corporation thereof, (ii) the
Participant's employment shall terminate by reason of Disability or Retirement,
or (iii) there is a Change in Control, then in any such case all Restricted
Shares theretofore granted to such Participant shall become immediately vested
and nonforfeitable.

11.  Effect of Certain Changes.

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     (a) If there is any change in the number of outstanding shares of Common
Stock by reason of any stock dividend, stock split, recapitalization,
combination, exchange of shares, merger, consolidation, liquidation, split-up,
spin-off or other similar change in capitalization, any distribution to
shareholders, including a rights offering, other than cash dividends, or any
like change, then the number of shares of Common Stock available for Awards,
the number of such shares of Common Stock covered by outstanding Awards, and
the price per share of Options or the applicable market value of Rights, shall
be proportionately adjusted by the Committee to reflect such change or
distribution; provided, however, that any fractional shares resulting from such
adjustment shall be eliminated.

     (b) In the event of a change in the Common Stock as presently constituted,
which is limited to a change of all of its authorized shares with par value
into the same number of shares with a different par value or without par value,
the shares resulting from any such change shall be deemed to be Common Stock
within the meaning of this Plan.

     (c) To the extent that the foregoing adjustments relate to stock or
securities of the Company, such adjustments shall be made by the Committee,
whose determination in that respect shall be final, binding and conclusive,
provided that each Incentive Stock Option granted pursuant to this Plan shall
not be adjusted in a manner that causes such option to fail to continue to
qualify as an Incentive Stock Option within the meaning of Section 422 of Code.

12.  Agreement by Participant Regarding Withholding Taxes.

     If the Committee shall so require, as a condition of grant, exercise, or
settlement or otherwise, each Participant shall agree that:

          (a) no later than the date a Participant recognizes taxable income in
     connection with an Award granted hereunder in connection with the exercise
     or settlement of such Award or otherwise, the Participant will pay to the
     Company or make arrangements satisfactory to the Committee regarding
     payment of any federal, state or local taxes of any kind required by law
     to be withheld upon the exercise or settlement of such Award (any such
     tax, a "Withholding Tax"); and

          (b) the Company shall, to the extent permitted or required by law,
     have the right to deduct any Withholding Tax from any payment of any kind
     otherwise due to the Participant.

13.  Gross-Up for Excise Tax.

         An Award Agreement may provide that in the event that a Participant
becomes entitled by reason of a Change of Control to the accelerated vesting of
an Award, if such Participant will be subject to excise tax (the "Excise Tax")
under Section 4999 of the Code, the Company shall pay to such Participant as
additional compensation an amount (the "Gross-Up Payment") which, after payment
by such Participant of all taxes (including any federal, state and local income
tax and excise tax upon the payment provided for by this Section 13) allows
Participant to retain an amount of the Gross-Up Payment equal to the Excise
Tax. For purposes of determining whether a Participant will be subject to the
Excise Tax and the amount of such Excise Tax, (i) any other payments or
benefits received or to be received by such Participant in connection with a
Change in Control of the Company or the Participant's termination of employment
(whether pursuant to the terms of the Award Agreement or any other plan,
arrangement or agreement with the Company, any entity whose actions result in a
Change in Control of the Company or any entity affiliated with the Company or
such entity) shall be treated as "parachute payments" within the meaning of
Section 280G(b)(2) of the Code, and all "excess parachute payments" within the
meaning of Section 280G(b)(1) of the Code shall be treated as subject to the
Excise Tax, unless in the opinion of tax counsel selected by the Company's
independent auditors and reasonably acceptable to the Participant such other
payments or benefits (in whole or in part) do not constitute parachute
payments, including by reason of Section 280G(b)(4)(A) of the Code, or such
excess parachute payments (in whole or in part) represent reasonable
compensation for services actually rendered, within the meaning of Section
280G(b)(4)(B) of the Code, or are otherwise not subject to the Excise Tax, (ii)
the amount of payments or benefits treated as subject to the Excise Tax shall
be equal to the lesser of (A) the total amount of payments or benefits
conferred on such Participant by reason of the Change of Control or (B) the
amount of excess parachute payments within the meaning of Section 280G(b)(1) of
the Code (after applying clause (i), above), and (iii) the value of any noncash
benefits or any deferred payment or benefit shall be determined by the
Company's independent auditors in accordance with the principles of Sections
280G(d)(3) and (4) of the Code. For purposes of determining the amount of the
Gross-Up Payment, the Participant shall be deemed to pay federal income taxes
at the highest marginal rate of federal income taxation in the calendar year in
which the Gross-Up Payment is to be made

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and state and local income taxes at the highest marginal rate of taxation in
the state and locality of the Participant's residence on the date on which the
Excise Tax is incurred, net of the maximum reduction in federal income taxes
which could be obtained from deduction of such state and local taxes. In the
event that the Excise Tax is subsequently determined to be less than the amount
taken into account hereunder, the Participant shall repay to the Company, at
the time that the amount of such reduction in Excise Tax is finally determined,
the portion of the Gross-Up Payment attributable to such reduction (plus that
portion of the Gross-Up Payment attributable to the Excise Tax and federal,
state and local income tax deduction) plus interest on the amount of such
repayment at the rate provided in Section 1274(b)(2)(B) of the Code. In the
event that the Excise Tax is determined to exceed the amount taken into account
hereunder (including by reason of any payment the existence or amount of which
cannot be determined at the time of the Gross-Up Payment), the Company shall
make an additional Gross-Up Payment in respect of such excess (plus any
interest, penalties or additions payable by the Participant with respect to
such excess) at the time that the amount of such excess finally is determined.
The Participant and the Company each shall reasonably cooperate with the other
in connection with any administrative or judicial proceedings concerning the
existence or amount of liability for Excise Tax.

14.  Termination and Amendment.

     Unless terminated by action of the Board of Directors or the Committee, no
Awards may be granted under this Plan after May 19, 2007. This Plan may be
amended or terminated at any time by the Committee, except that no amendment
may be made without shareholder approval if the Committee determines that such
approval is necessary to comply with any tax or regulatory requirement,
including any approval requirement which is a prerequisite for exemptive relief
from Section 16 of the Exchange Act, for which or with which the Committee
determines that it is desirable to qualify or comply. The Committee may amend
the terms of any Award Agreement and any Award granted, retroactively or
prospectively, but no amendment may adversely affect any vested Award without
the holder's consent.

15.  Effectiveness; Approval of Stockholders.

     This Plan, as amended and restated, shall take effect upon its adoption by
the Board of Directors, but its effectiveness and the exercise of any Awards
granted subsequent to the effectiveness of the amendment shall be subject to
the approval of the holders of a majority of the voting shares of the Company,
which approval must occur within twelve (12) months after the date this Plan is
adopted by the Board.

16.  Effect of Headings.

     The section and subsection headings contained herein are for convenience
only and shall not affect the construction hereof.

                                      15EXHIBIT 4.1

     The Laboratory Corporation of America Holdings 1997 Employee Stock
Purchase Plan was amended, effective June 16, 1999, to replace Article IV of
such plan with the following:

ARTICLE IV. Stock:

     The stock subject to the Options to be issued hereunder shall be Common
Stock. The maximum number of such shares to be issued upon the exercise of the
Options hereby granted shall be an aggregate of seven million five hundred
thousand (7,500,000) shares of Common Stock (the "Available Shares").

     For each Offering Period hereunder, an eligible employee (hereinafter
called "Optionee") shall have an option to purchase up to the largest number of
whole and fractional shares available at the Option Price (as described in
Article V(a) obtained by having deducted from such Optionee's Compensation for
each payroll period during an Offering Period an amount not less than one
percent (1%) or more than ten percent (10%) of such Optionee's Compensation for
the payroll period. The term "Compensation" as used herein includes regular
base pay (including any shift differentials) at the rate in effect on the
Offering Date, but excludes any bonus, overtime payment, sales commission,
contribution to any Code ss.125 or 401(k) plan or other form of extra
compensation.

     If in any Offering Period the total number of shares of Common Stock for
which Options are exercised exceeds the number of Available Shares remaining
under the Plan, the Administrator shall make a pro rata allocation of the
Available Shares in as nearly a uniform manner as shall be practicable and as
it shall deem to be equitable, and the balance of payroll deductions credited
to the Purchase Account of each Optionee shall be returned to each Optionee as
promptly as possible.

     Except as expressly provided otherwise in Article III hereof, payment for
Common Stock purchased under the Option shall be made only by payroll
deductions over a designated Offering Period.

     Notwithstanding the foregoing provisions of this Plan, no Option shall
permit an Optionee to purchase in any single calendar year a number of shares
which together with all other shares in the corporation and any Subsidiaries
which such Optionee may be entitled to purchase in such year pursuant to
options issued under any employee stock purchase plan, has an aggregate fair
market value (determined in each case as of the date such options are granted)
in excess of $25,000. This limitation applies only to options granted under
"employee stock purchase plans" as defined by ss.423 of the Code, and does not
limit the amount of stock which an Optionee may purchase under any other stock
option or bonus plans then in effect.

                                       8

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