Document:

Exhibit

AMENDMENT NO. 1 TO
FOURTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT

This Amendment No. 1 to Fourth Amended and Restated Investor Rights Agreement (this “Amendment”) is entered into as of May 8, 2018 by the undersigned parties to that certain Fourth Amended and Restated Investor Rights Agreement, dated as of July 13, 2015 (the “Rights Agreement”), by and among AnaptysBio, Inc., a Delaware corporation (the “Company”) and the Investors. Capitalized terms used but not defined herein shall have the meanings ascribed to them in the Rights Agreement.

RECITALS

A.        WHEREAS, the Company’s Board of Directors has determined it is in the best interests of the Company and its stockholders to amend certain provisions in the Rights Agreement with respect to registration rights.

B.        WHEREAS, Section 5.5(a) of the Rights Agreement provides that any provision of the Rights Agreement may be amended with the written consent of the Company and the holders of at least a majority of the then-outstanding Registrable Securities (the “Requisite Holders”).

C.        WHEREAS, the undersigned Investors, who collectively constitute the Requisite
Holders, desire to amend the Rights Agreement all as set forth below.

NOW, THEREFORE, in consideration of the foregoing recitals and for other good and valuable consideration, the adequacy and sufficiency of which are hereby acknowledged, the undersigned hereby agree as follows:

1.         Amendment to Section 2.14. Section 2.14 of the Rights Agreement is hereby amended and restated in its entirety to state the following:

“2.14   Termination of Registration Rights. The right of any Holder to request registration or inclusion of Registrable Securities in any registration pursuant to Section 2.2, 2.3 or 2.4 hereof shall terminate upon the earlier of: (i) the date five years following the closing of a Qualified IPO; (ii) such time as the Company has completed its Initial Offering and all Registrable Securities issuable or issued upon conversion of the Shares held by and issuable to such Holder (and its affiliates) may be sold pursuant to Rule 144 during any 90-day period. Upon such termination, such shares shall cease to be “Registrable Securities” hereunder for all purposes.”

2.         Full Force and Effect. This Amendment is being effected in compliance with all relevant provisions of the Rights Agreement (including Section 5.5(a) thereof) and applicable law. Except as expressly modified herein, the Rights Agreement shall remain in full force and effect.

3.         Governing Law.  This Amendment shall be governed by, and construed and interpreted in accordance with the laws of the State of Delaware as applied to agreements among Delaware residents made and to be performed entirely within the State Delaware.

4.         Counterparts. This Amendment may be executed in counterparts, delivered by facsimile or portable document format (.pdf or similar format), each of which will constitute an original and all of which together will constitute one agreement.

The parties are signing this Amendment as of the date stated in the introductory clause.

	
				
	 
	COMPANY:

	 
	 
	 
	 

	 
	ANAPTYSBIO, INC.

	
					
	 
	By:
	 
	/s/ Hamza Suria
	 

	 
	 
	 
	Hamza Suria
	 

	 
	 
	 
	President and CEO
	 

	 
	 
	 
	 
	 

	
				
	 
	Address:
	 
	10421 Pacific Center Court

	 
	 
	 
	Suite 200

	 
	 
	 
	San Diego, CA 92121

The parties are signing this Amendment as of the date stated in the introductory clause.

	
				
	 
	INVESTOR:

	 
	 
	 
	 

	 
	FRAZIER HEALTHCARE V, LP

	 
	 
	 
	 

	 
	By FHM V, LP, its general partner

	 
	By FHM V, LLC, its general partner

	
					
	 
	By:
	 
	/s/ Steve Bailey
	 

	 
	Name:
	 
	Steve Bailey
	 

	 
	Title:
	 
	CFO
	 

The parties are signing this Amendment as of the date stated in the introductory clause.

	
				
	 
	INVESTOR:

	 
	 
	 
	 

	 
	FRAZIER HEALTHCARE VII, L.P.

	
					
	 
	By:
	 
	/s/ Steve Bailey
	 

	 
	Name:
	 
	Steve Bailey
	 

	 
	Title:
	 
	CFO
	 

The parties are signing this Amendment as of the date stated in the introductory clause.

	
				
	 
	INVESTOR:

	 
	 
	 
	 

	 
	FRAZIER HEALTHCARE VII-A, L.P.

	
					
	 
	By:
	 
	/s/ Steve Bailey
	 

	 
	Name:
	 
	Steve Bailey
	 

	 
	Title:
	 
	CFOExhibit

SUBLEASE

1.        PARTIES.
This Sublease, dated May 18, 2018 (the “Effective Date”) is made between Trex Enterprises Corporation,   a   California   corporation,   (“Sublessor”),   and   AnaptysBio,   Inc.,   a   Delaware corporation (“Sublessee”).

2.        MASTER LEASE.
Sublessor is the lessee under a written lease dated April 21, 2016 and the first Amendment dated January 20, 2017 (together, the “Master Lease”) wherein Kilroy Realty, L.P., a Delaware limited partnership leased to Sublessor the real property located in the City of San Diego, County of San Diego, State of California, described as: 10455 Pacific Center Court, San Diego, California, 92121 (“Master Premises”).  A subsequent sale in ownership of the Master Premises led to the transfer of the Master Lease to CIO Sorrento Mesa, LLC (the “Lessor”), the notice for which is attached as Exhibit “A” to this Sublease.

3.        PREMISES.
Sublessor hereby subleases to Sublessee on the terms and conditions set forth in this Sublease the following portion of the Master Premises: approximately 18,322 rentable square feet on the 2nd floor of the building, commonly known as Suite 200 (the “Premises”), as depicted on Exhibit “B”, attached hereto and incorporated by this reference herein.

4.       WARRANTY BY SUBLESSOR.
Sublessor warrants and represents to Sublessee that (a) Sublessor is not now, and as of the Commencement Date (as defined below) will not be, in default or breach of any of the provisions of the Master Lease, (b) Sublessor has no knowledge of any claim by Lessor that Sublessor is in default or breach of any of the provisions of the Master Lease, (c) the Master Lease is in full force and effect, and (d) the Master Lease has not been modified or amended, except as set forth herein.

5.        TERM.
The term of the Sublease (the “Sublease Term”) shall be for forty (40) months.  The Sublease Term shall commence upon the date (the “Commencement Date”) which is the later of:  (a) July 7, 2018, or (b) forty-five (45) days following the date in which the Premises is delivered to Sublessee in the Delivery Condition, as defined in Section 6 below (the “Delivery Date”) or (c) the date Lessor consents in writing to this Sublease, in a form reasonably acceptable to Sublessor and Sublessee.  This Sublease and Sublessor’s and Sublessee’s obligations hereunder are conditioned upon and subject to the prior written consent of Lessor to this Sublease, in a form reasonably acceptable to Sublessor and Sublessee (provided, however, it shall be reasonable for Sublessee to withhold approval of such a   consent document if the consent document does not contain express  Lessor  approval  of  Sublessee’s  Work  (and  agreement  that  Sublessee  shall  not  be obligated  to  restore  the  Premises to  its  prior  condition  or  remove  Sublessee’s Work  upon termination of the Sublease for any reason), Lessor’s approval of Sublessee’s signage rights as provided herein, and an agreement by Lessor to provide Sublessee with a copy of any notices of default delivered to sublessor pursuant to Master Lease).   Sublessor agrees to use good faith efforts  to obtain the consent of Lessor.  If the written consent of Lessor is not obtained on or before 5:00 P.M. Pacific Time on the date which is thirty (30) days after the Effective Date of this Sublease, this condition precedent shall fail, this Sublease shall be void and of no force or effect, and neither Sublessor nor Sublessee shall have any rights against or obligations to the other any rights against or obligations to the other under this Sublease. In such event, Sublessor shall promptly return any Security Deposit and prepaid rent to Sublessee.   The Delivery Date is estimated to occur on approximately May 23, 2018 (the “Estimated Delivery Date”). If for any reason Sublessor does not deliver the Premises in the Delivery Condition by the Estimated Delivery  Date,  the  validity  of  this  Sublease  shall  not  be  impaired.    Notwithstanding  the foregoing, if Sublessor has not delivered the Premises with the Delivery Conditions satisfied by June 7, 2018, then at any time thereafter and before delivery of the Premises to Sublessee in the Delivery Condition, Sublessee may give written notice to Sublessor of Sublessee’s intention to cancel this Sublease.  Said notice shall set forth an effective date for such cancellation which shall be at least ten (10) days after delivery of said notice to Sublessor. If Sublessor 

delivers the Premises to Sublessee in the Delivery Condition on or before the expiration of the ten (10) day period, this Sublease shall remain in full force and effect.   If Sublessor fails to deliver the Premises to Sublessee in the Delivery Condition on or before such effective date, this Sublease shall be cancelable by Sublessee, in which case all consideration previously paid by Sublessee to Sublessor  on  account  of  this Sublease  shall  be  returned  to  Sublessee, this Sublease shall thereafter be of no further force or effect, and Sublessor shall have no further liability to Sublessee on account of such delay or cancellation.

6.        RENT.
Sublessee shall pay to Sublessor as Base Rent, Direct Expenses and Utilities without deduction, setoff, notice or demand (except as provided herein), at 10455 Pacific Center Court I San Diego, CA 92121-4339, or at such other place as Sublessor shall designate from time to time by written notice  to  Sublessee.    Sublessee  shall  pay  to  Sublessor  upon  execution  of  this  Sublease $37,461.77 as Base Rent and Direct Expenses for the first month of the Sublease Term and, within ten (10) days of the later of (a) Effective Date or (b) the date Lessor consents in writing to this Sublease, an additional $33,034.56 as a Security Deposit to be treated in the same manner as is outlined in the Master Lease, and as set forth in this Section 6. If the Sublease Term begins on a day other than the first day of a month, the Base Rent, Direct Expenses and utilities for the partial months shall be prorated on a per diem basis based on the actual number of days in the month in which the Sublease commences. Additional provisions:

		
	•
	PREMISES: Sublessor shall retain the server room, electrical room and large room opposite the server room (areas not highlighted on floor plan in the brochure previously delivered to Sublessee). The rentable square footage listed on the market brochure included these areas and Sublessor confirmed with the architect the new rentable square footage, excluding these areas, of 18,322 RSF.

		
	•
	USE: The Premises will be used for general office use and all legal uses consistent with a first-class office/R&D building. Sublessee shall not conduct or operate any labs on the Premises. Sublessee shall obtain written approval of any changes in use and such approval shall not be unreasonably withheld, conditioned or delayed (but shall be conditioned on Lessor approval).

		
	•
	EARLY ACCESS: As set forth in Section 5, Sublessee will have access to the Premises forty- five (45) days prior to the Commencement Date to allow Sublessee to complete approved tenant improvements, move its furniture and equipment into the space and to complete any cabling or fixturization to be done by Sublessee. Sublessee will have no obligation to pay Base Rent or Direct Expenses during such early access period. 

		
	•
	EXTENSION OPTIONS: Sublessee shall have three (3) options to extend the Sublease Term for consecutive one (1) year periods (each, an “Extension Option”), by providing Sublessor with not less than one hundred eighty (180) days written notice prior to the expiration of the current term at a three percent (3%) increase of the prior months’ Base Rent. 

		
	•
	BASE RENT: The monthly base rent (the “Base Rent”) will be one dollar and sixty-five cents ($1.65) per rentable square foot of the Premises on a Triple Net basis. The Base Rent will increase by three percent (3%) of the previous Base Rent upon each anniversary of the Commencement Date. 

		
	•
	RENT ABATEMENT: Sublessee’s Base Rent will be unconditionally abated for three (3) months during months two through four (months 2-4) of the initial Sublease Term. For the avoidance of doubt, no abated rent will be required to be repaid upon the occurrence of an event of default by Sublessee under the Sublease. 

		
	•
	DIRECT EXPENSES: Sublessor currently pays $0.3946 per rentable square foot per month for Direct Expenses, as such term in defined in the Master Lease (including property taxes), subject to increase by the Lessor. Sublessee shall pay for its pro rata share of Direct Expenses (which the parties agree shall be 45.15% of the Direct Expenses charged to Sublessor); provided, however , for the purposes of this Sublease, in no event shall Direct Expenses include (i) increases in property taxes due to a sale or other disposition of the Property or (ii) expenses for capital repairs or improvements, except to the extent such items proportionately reduce Direct Expenses or are required to comply with Applicable Laws first enacted after January 1, 2018, and in any event all capital expenditures will be 

amortized over the useful life of the capital improvement in accordance with generally accepted accounting principles, consistently applied. One time per calendar year, at its sole cost and expense, Sublessee will be entitled to audit the Building’s Direct Expenses using any reputable firm which regularly provides such services (subject to rights in Master Lease). Sublessor shall enforce any audit rights it may have at the request of Sublessee under Section 4.6 of the Master Lease. In the event the Direct Expenses are adjusted pursuant to the Master Lease, Sublessee shall be responsible for any increase in its pro rata share of Direct Expenses assessed as a result of the audit. Further, if the Direct Expenses are decreased as a result of such audit, Sublessee may offset future Direct Expenses payments in the amount of such difference or, if the Sublease Term has expired, Sublessor shall reimburse Sublessee for such difference within thirty (30) days after demand for payment. 
		
	•
	UTILITIES: Sublessee will be responsible for the payment of its pro-rata share of utilities to the Premises. Sublessee shall be responsible for 45.15% of the monthly SDG&E utility bill for the Master Premises. Payment for utilities is due within 30 days of receipt of invoice. 

		
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	TRASH AND JANITORIAL SERVICES: All janitorial and trash services shall be contracted and paid for separately by Sublessee. To the extent Sublessee requests in writing and Sublessor consents in writing to allow Sublessee to utilize the same on-site services provided to Sublessor, Sublessee shall pay its pro-rata share of those services (i.e., 45.15%). Payment for such services is due within 30 days of receipt of invoice. 

		
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	RECEPTIONIST SERVICES: Receptionist services are not provided to Sublessee under this Sublease. 

		
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	SECURITY DEPOSIT: Within ten (10) days of the later of (a) full execution of the Sublease and (b) Lessor’s written consent to this Sublease, Sublessee will provide Sublessor a security deposit in the amount of the last month’s Base Rent (i.e. $33,034.56). 

		
	•
	SUBLESSEE’S WORK/ SURRENDER: Sublessee intends to make certain initial tenant improvements to the Premises, as set forth in the attached Exhibit “C”(“Sublessee's Work”). Sublessee’s Work is hereby approved by Sublessor to the extent the Sublessee’s Work complies with the terms of the Master Lease.  Sublessee is obligated to confirm that its intended alterations or improvements, including Sublessee’s Work, complies with the Master Lease. Any further changes to Sublessee’s Work, or any other improvements or alterations during the Sublease Term which require Sublessor or Lessor consent as set forth herein and in Section 8.1 of the Master Lease, shall be subject to Sublessor’s and Lessor’s review and approval, which shall not be unreasonably withheld, conditioned or delayed. Also such improvements shall be at Sublessee’s sole cost and expense. Notwithstanding the terms of the Master Lease, Sublessor shall promptly respond to any such approval requests. In the event Lessor approves Sublessee’s request for consent to improvements or alterationsas provided hereunder, Sublessor’s failure to respond to the same request for consent by Sublessee within ten (10) business days following Lessor’s written consent shall be deemed Sublessor’s approval of the same. Upon the expiration or earlier termination of this Sublease, notwithstanding any surrender or restoration obligations in the Master Lease, in no event shall Sublessee be required to remove any improvements, alterations or fixtures (including, without limitation, Sublessee’s Work), or otherwise restore the Premises to the condition that existed on the Effective Date, it being understood that Sublessee’s sole obligation upon the expiration of the Sublease Term shall be to surrender the Premises in good, broom-clean condition, with reasonable wear and tear, repairs which are Lessor’s or Sublessor’s responsibility, excepted.

		
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	INDEMNIFICATION FOR SUBLESSEE'S WORK: Sublessee, including its representatives, employees, or other agents, indemnifies, holds harmless and shall defend Sublessor against any and all damages, claims, actions, or other injury arising from or related to Sublessee's Work, except to the extent that such injury arises from Sublessor's own negligence or willful misconduct. 

		
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	CONDITION OF PREMISES: Sublessor, at its sole cost, will deliver the Premises, on or before the Delivery Date, broom clean, in good operating condition and repair, with all necessary maintenance, repairs and replacements performed, in compliance with all Applicable Laws, (as such term is defined in Master Lease) and with the Server Room Door Work complete (together, the “Delivery Condition”), subject to Sublessee’s Work. Sublessor will warrant all existing mechanical, electrical, roof and plumbing systems for the first year of the Sublease Term (“Warranty Period”) and Sublessor will maintain, repair or 

replace such existing systems as needed during the Warranty Period at no cost to Sublessee, including, without limitation, through Direct Expenses, provided, however Sublessor does not warrant any improvements made by Sublessee. 
		
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	PARKING: Sublessee shall be entitled to 63 parking spaces in the parking lot, together with 2 visitor parking spaces. 

		
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	FURNITURE, FIXTURES, EQUIPMENT: Sublessee shall have use but shall not acquire ownership of existing network cabling, office desks, conference room furniture including board room, and other items listed on Exhibit “D” attached hereto (the “Sublessor FF&E”) throughout the entire Sublease Term at no additional cost to Sublessee.

		
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	IDENTITY & SIGNAGE: Subject to the terms of the Master Lease, and Lessor’s consent to the terms hereof, Sublessee will be permitted to install, at its expense and subject to Sublessor’s and Lessor’s consent which will not be unreasonably withheld, signage at the entrance of its Premises on the second floor of the building. Signage will be in accordance with Building standards and Lessor’s signage program. Sublessor, at Sublessee’s expense, will furnish Sublessee with space on the Building directory. In addition, Sublessee will be allowed a non-exclusive monument sign at (1) Building entry location facing Pacific Center Court and (2) identity incorporated amongst way-finding signage around the Building/Project (e.g. Shipping and receiving, Reception), subject to Lessor’s consent. All costs associated with said signage, including but not limited to, fabrication, installation, and removal will be at Sublessee’s expense. 

		
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	BUILDING SECURITY: Securitization of the sublease space including movement of doors on south side near server room to be performed by Sublessor prior to the Delivery Date (the “Server Room Door Work”). Sublessee shall have access to first floor stairs on east side of the building for emergency purposes only. 

		
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	HOLDING OVER: Should Sublessee hold over in its sublease space with notice and approval, the Base Rent will be adjusted to 150% of the Base Rent in effect during the last month of the Sublease Term or extended periods, as applicable.

		
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	ASSIGNMENT AND SUBLETTING. Sublessee shall not mortgage, hypothecate, assign, or sublet any part of the Premises without the prior written consent of Sublessor and, if Sublessor under the Master Lease must obtain such consent from Lessor, the prior written consent of Lessor. Such consent by Sublessor shall not be unreasonably withheld, conditioned, or delayed.

		
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	EARLY TERMINATION. In the event Sublessor exercises its Early Termination Right under Section 2.3 of the Master Lease: (1) this Sublease shall terminate upon the termination of the Master Lease, i.e. April 30, 2023 (the "Termination Date"), notwithstanding any prior exercise of an Extension Option by Sublessee, and (2) Sublessee's remaining Extension Option(s) are void. Sublessor shall provide written notice to Sublessee of Sublessor's intent to exercise its Early Termination Right no later than August 1, 2022 (i.e., the date nine (9) months preceding the Termination Date).

7.        MASTER LEASE.
This Sublease is subordinate to the Master Lease. Sublessee assumes and agrees to perform the lessee’s obligations under the Master Lease during the Sublease Term to the extent that such obligations are applicable to the Premises, except to the extent such obligations are modified by the terms of this Sublease (including, without limitation, the obligation to pay rent to Lessor under the Master Lease shall be considered performed by Sublessee to the extent and in the amount rent is paid to Sublessor in accordance with Section 6 of this Sublease). Sublessor shall perform the lessor’s obligations under the Master Lease during the Sublease Term to the extent such obligations are applicable to the Premises except to the extent such obligations are modified by the terms of this Sublease. Sublessee shall not commit or suffer any act or omission  that  will  violate  any  of  the  provisions of  the  Master  Lease; provided, however, Sublessor acknowledges that Sublessee’s obligations have been modified as set forth herein. Sublessor shall exercise due diligence in attempting to cause Lessor to perform its obligations under the Master Lease for the benefit of Sublessee.   If the Master Lease terminates, this Sublease shall terminate and the parties shall be relieved of any further liability or obligation under this Sublease.  Notwithstanding the foregoing, if the Master Lease gives Sublessor any right to terminate the Master Lease in the event of the partial or total damage, destruction, or condemnation of the Master Premises or the building or project of which the Master Premises are a part, the exercise of such right by Sublessor shall not constitute a default or breach hereunder. Sublessor shall fully and punctually pay all rent and any other sums due and payable to Lessor, as and when the same shall become due and payable 

under the Master Lease, and perform all obligations required of Sublessor thereunder. Sublessor shall provide Sublessee a copy of any notice it receives from the Lessor pursuant to, or concerning the Master Lease within three (3) business days of Sublessor’s receipt thereof.  In the event of any conflict between the terms of this Sublease and the terms of the Master Lease, the terms of the Master Lease shall govern; provided, however, to the extent this Sublease modifies the terms of the Master Lease as between Sublessor and Sublessee, the terms of this Sublease shall govern.
7.1 Sublessor Default. Sublessor shall be in default under this Sublease if Sublessor fails to:  (a) pay any obligation of Sublessor under the Lease and said failure continues for three (3) business days after receipt of notice from Sublessee of the same; (b) perform any other act or acts required by Sublessor under the Lease and said failure continues for three (3) business days after receipt of notice from Sublessee or Lessor of the same;   (c) perform any act or acts required of Sublessor by this Sublease and such failure continues for thirty (30) days after receipt of notice from Sublessee or (d) any other default under the terms of the Master Lease. In the event of a default by Sublessor, including without limitation a default under subclause (a) above,  Sublessee may pay or perform any obligation of Sublessor, in addition to the right to exercise all other legal and equitable remedies of Sublessee (including, without limitation, the right to immediately terminate the Sublease).  If Sublessee elects to pay or perform any such obligation  of  Sublessor,  Sublessor  shall,  within  twenty  (20)  days  of  demand,  reimburse Sublessee  the  reasonable amount paid or out-of-pocket costs or expenses so incurred by Sublessee.   If Sublessor fails to timely pay or reimburse Sublessee for any amount owed to Sublessee under this Sublease by Sublessor, Sublessee may offset the amount so owed or to be reimbursed against Rent along with interest at the highest rate permitted by law.

8.         INSURANCE.  Sublessee shall at all times maintain commercial general liability coverage with limits not less than $1,000,000 per occurrence and $2,000,000 aggregate for bodily injury and property damage liability.
8.1 - Waiver of Subrogation.    Notwithstanding any provision herein to the contrary, the parties hereto expressly release each other and the Master Landlord from and waive any rights of recovery that each may have against the other for any and all liability and expense for loss, damage  or  destruction  of  property  resulting  from  perils (including negligent acts or omissions of Sublessee, Sublessor, or Lessor, and their respective agents, employees, associates or invitees) covered by the insurance policies which such parties are obligated to purchase and maintain pursuant to this Sublease (or, in the case of Sublessor, pursuant to the master Lease); and the parties mutually agree that their respective insurance companies shall have no right of subrogation against the other party or Lessor on account thereof. Sublessor agrees to request Lessor to extend the subrogation waiver provisions of the Master Lease to Sublessee.

9.         INDEMNIFICATION:   Sublessee shall indemnify, protect, defend and save Sublessor harmless from and against any and all liens, claims, demands, actions, causes of action, obligations, penalties,  charges,  liabilities,  damages,  losses,  costs  or  expenses,  including  reasonable attorney’s fees for the defense thereof (“Liabilities”), arising from, out of or in connection with Sublessee’s use of the Premises or any breach of or any default in the performance of Sublessee’s obligations under this Sublease or any negligent act or omission of Sublessee, or any of Sublessee’s officers, directors, employees or agents; except to the extent such Liabilities are caused or contributed to by the negligence or willful acts or omissions of Sublessor, its agents, contractors or employees.   Sublessor shall indemnify, defend, and hold Sublessee harmless from Liabilities caused by Sublessor’s breach or default of its obligations under the Master Lease and asserted against or sustained by Sublessee, including any termination of the Master Lease as a result of Sublessor’s default thereunder.

10.      ATTORNEYS’ FEES.
If Sublessor or Sublessee shall take any action or commence any legal proceedings against the other arising out of or in connection with this Sublease, the prevailing party shall be entitled to recover its costs of suit and reasonable attorneys’ fees.

11.      AGENCY DISCLOSURE.
Sublessor and Sublessee each warrant that they have dealt with no other real estate broker in connection  with  this  transaction  except  Hughes  Marino,  who  represents Trex  Enterprises 

Corporation, a California corporation, and Kidder Mathews, who represents AnaptysBio, Inc., a Delaware corporation.

12.      COMMISSION.
Upon execution of this Sublease, and consent thereto by Lessor, Sublessor shall pay Kidder Mathews a real estate brokerage commission equal to four percent (4%) of the Base Rent for services rendered in effecting this Sublease.

Hughes Marino is waiving its Commission for services rendered in effecting this Sublease.

13.     NOTICES.
All notices  and  demands  which may or are  to  be  required  or permitted  to  be given by either party on the other hereunder shall be in writing.  All notices and demands by the Sublessor to Sublessee shall be mailed to the Sublessee at the Premises and to Tenant at: 10421 Pacific Center Court, Suite 200,   San Diego, CA 92121, Attn: Chief Financial Officer, or to  such other place as Sublessee may from time to time designate in a  notice to the Sublessor.  All notices and demands by the Sublessee to Sublessor shall be mailed to the Sublessor at the address set forth above, and to such other person or place as the Sublessor may from time to time designate in a  notice to the Sublessee.

14.     GOVERNING LAW.  This Sublease shall be construed and enforced in accordance with the laws of the State of California.

15.     COUNTERPARTS.  This Sublease may be executed in counterparts with the same effect as if both parties hereto had executed the same document.   Both counterparts shall  be construed together and shall constitute a  single Sublease.

SUBLESSOR:

	
					
	 
	TREX ENTERPRISES CORPORATION

	 
	a California corporation
	 

	 
	 
	 
	 
	 

	 
	By:
	 
	/s/ Kenneth Y. Tang
	 

	 
	Name:
	 
	Kenneth Y. Tang
	 

	 
	Title:
	 
	Chairman and CEO
	 

	 
	 
	 
	 
	 

	 
	By:
	 
	/s/ Deborah A. Doyle
	 

	 
	Name:
	 
	Deborah A. Doyle
	 

	 
	Title:
	 
	COO and CFO
	 

SUBLESSEE:
	
					
	 
	ANAPTYSBIO, INC.,
	 

	 
	a Delaware corporation
	 

	 
	 
	 
	 
	 

	 
	By:
	 
	 
	 

	 
	Name:
	 
	 
	 

	 
	Title:
	 
	 
	 

	 
	 
	 
	 
	 

	 
	By:
	 
	 
	 

	 
	Name:
	 
	 
	 

	 
	Title:
	 
	 
	 

13.     NOTICES.
All notices  and  demands  which may or are  to  be  required  or permitted  to  be given by either party on the other hereunder shall be in writing.  All notices and demands by the Sublessor to Sublessee shall be mailed to the Sublessee at the Premises and to Tenant at: 10421 Pacific Center Court, Suite 200,   San Diego, CA 92121, Attn: Chief Financial Officer, or to  such other place as Sublessee may from time to time designate in a  notice to the Sublessor.  All notices and demands by the Sublessee to Sublessor shall be mailed to the Sublessor at the address set forth above, and to such other person or place as the Sublessor may from time to time designate in a  notice to the Sublessee.

14.     GOVERNING LAW.  This Sublease shall be construed and enforced in accordance with the laws of the State of California.

15.     COUNTERPARTS.  This Sublease may be executed in counterparts with the same effect as if both parties hereto had executed the same document.  Both counterparts shall  be construed together and shall constitute a  single Sublease.

SUBLESSOR:

	
					
	 
	TREX ENTERPRISES CORPORATION

	 
	a California corporation
	 

	 
	 
	 
	 
	 

	 
	By:
	 
	 
	 

	 
	Name:
	 
	 
	 

	 
	Title:
	 
	 
	 

	 
	 
	 
	 
	 

	 
	By:
	 
	 
	 

	 
	Name:
	 
	 
	 

	 
	Title:
	 
	 
	 

SUBLESSEE:

	
					
	 
	ANAPTYSBIO, INC.,
	 

	 
	a Delaware corporation
	 

	 
	 
	 
	 
	 

	 
	By:
	 
	/s/ Hamza Suria
	 

	 
	Name:
	 
	Hamza Suria
	 

	 
	Title:
	 
	President and CEO
	 

	 
	 
	 
	 
	 

	 
	By:
	 
	 
	 

	 
	Name:
	 
	 
	 

	 
	Title:
	 
	 
	 

Exhibit A

EXHIBIT B
SITE PLAN

EXHIBIT C
SUBLESSEE'S WORK

EXHIBIT D
SUBLESSOR FF&E

To remain in suite:
1. Board room table
2. Board room chairs – 15
3. Board room refrigerator
4. Board room TV and stand
5. Conference room installed TV
6. Conference room installed whiteboard
7. Conference room table – no chairs
8. Conference room table – no chairs

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