Document:

exv10w1

 

Exhibit 10.1

 

LETTER OF CREDIT AND REIMBURSEMENT AGREEMENT

Between

GENITOPE CORPORATION

Borrower

and

COMERICA BANK

Bank

Dated as of December 15, 2005

 

 

 

TABLE OF CONTENTS

	 	 	 	 	 
	 	 	Page	 
	ARTICLE I DEFINITIONS AND USAGE
	 	 	1	 
	Section 1.1 Definitions
	 	 	1	 
	Section 1.2 Computation of Time Periods
	 	 	6	 
	Section 1.3 Accounting Terms
	 	 	7	 
	Section 1.4 Interpretation
	 	 	7	 
	ARTICLE II AMOUNT AND TERMS OF THE LETTER OF CREDIT
	 	 	7	 
	Section 2.1 The Letters of Credit
	 	 	7	 
	Section 2.2 Issuing the Letter of Credit
	 	 	7	 
	Section 2.3 Fees
	 	 	8	 
	Section 2.4 Reimbursement
	 	 	8	 
	Section 2.5 Default Rate
	 	 	8	 
	Section 2.6 Increased Costs
	 	 	8	 
	Section 2.7 Payments and Computations
	 	 	9	 
	Section 2.8 Evidence of Debt
	 	 	10	 
	Section 2.9 Obligations Absolute
	 	 	10	 
	Section 2.10 Security
	 	 	10	 
	ARTICLE III CONDITIONS OF ISSUANCE
	 	 	11	 
	Section 3.1 Conditions Precedent to Issuance of the Letter of Credit
	 	 	11	 
	Section 3.2 Additional Conditions Precedent to Issuance of the Letter of Credit
	 	 	12	 
	ARTICLE IV REPRESENTATIONS AND WARRANTIES
	 	 	13	 
	Section 4.1 Representations and Warranties
	 	 	13	 
	ARTICLE V COVENANTS OF THE BORROWER
	 	 	15	 
	Section 5.1 Affirmative Covenants
	 	 	15	 
	Section 5.2 Negative Covenants
	 	 	18	 
	ARTICLE VI EVENTS OF DEFAULT
	 	 	19	 
	Section 6.1 Events of Default
	 	 	19	 
	Section 6.2 Remedies Upon an Event of Default
	 	 	21	 
	ARTICLE VII GENERAL PROVISIONS
	 	 	21	 
	Section 7.1 Notices, Etc
	 	 	21	 

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TABLE OF CONTENTS

(continued)

	 	 	 	 	 
	 	 	Page	 
	Section 7.2   Survival of Covenants; Successors and Assigns
	 	 	22	 
	Section 7.3   Participations
	 	 	22	 
	Section 7.4   Right of Set-Off
	 	 	22	 
	Section 7.5   Liability of Bank: Indemnification
	 	 	23	 
	Section 7.6   Liability of the Bank
	 	 	23	 
	Section 7.7   Expenses and Taxes
	 	 	24	 
	Section 7.8   No Waiver; Conflict
	 	 	24	 
	Section 7.9   Modification, Amendment, Waiver, Etc
	 	 	24	 
	Section 7.10 Dealing with the Borrower
	 	 	24	 
	Section 7.11 Severability
	 	 	24	 
	Section 7.12 Counterparts
	 	 	24	 
	Section 7.13 Table of Contents; Headings
	 	 	24	 
	Section 7.14 Prior Agreements Superseded
	 	 	24	 
	Section 7.15 CHOICE OF LAW AND VENUE; JURY TRIAL WAIVER
	 	 	25	 
	Section 7.16 Reference Provision
	 	 	25	 

-ii-

 

LETTER OF CREDIT AND REIMBURSEMENT AGREEMENT

     This Letter of Credit and Reimbursement Agreement, dated as of December 15, 2005 (this
“Agreement”), is by and between GENITOPE CORPORATION, a Delaware corporation (the “Borrower”), and
COMERICA BANK, a Michigan banking corporation (the “Bank”).

     The parties hereto hereby agree as follows:

ARTICLE I

DEFINITIONS AND USAGE

     Section 1.1 Definitions. As used in this Agreement,

     “Account” means the collateral custodial account established by Borrower with
Securities Intermediary pursuant to the Custodial Account Agreement and all cash, securities and
investments (including, without limitation, all Approved Investments) from time to time in or
credited to the Account, as described in the Supplemental Letter between Bank and Borrower of even
date herewith.

     “Account Control Agreement” means that certain Account Control Agreement, dated as of
even date herewith, among the Borrower, Bank and the Securities Intermediary.

     “Account Manager” shall mean Payden & Rygel, in its capacity as manager of the
Account.

     “Account Pledge Agreement” means that certain Security Agreement-Account Pledge, dated
as of even date herewith, between the Borrower and the Bank pursuant to which Bank is granted a
first priority security interest in the Account, all cash, instruments and securities from time to
time in the Account, and in the Certificates of Deposit and all proceeds of the foregoing.

     “Affiliate” for any specified Person means any other Person directly or indirectly
controlling or controlled by or under direct or indirect common control with such specified Person.
For purposes of this definition, “control” when used with respect to any specified Person, means
the power to direct the policies of such Person, directly or indirectly, whether through the power
to appoint and remove members of its Governing Body, the ownership of voting securities, by
contract, or otherwise; and the terms “controlling” and “controlled” have meanings correlative to
the foregoing.

     “Agreement” means this Letter of Credit and Reimbursement Agreement as it may be
amended or supplemented from time to time in accordance with its terms.

     “Approved Investment” means (i) cash, (ii) money market instruments, (iii)United
States Treasury bills, and (iv) other United States Federal agency securities which carry the
direct or implied guaranty of the government of the United States (i.e., securities of the
Government National Mortgage Association, Federal Home Loan Bank and Federal National Mortgage
Association).

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     “Bank” has the meaning set forth in the preamble hereto.

     “Bank Rate” means the higher of (i) the Base Rate or (ii) the Federal Funds Rate plus
1.00% per annum.

     “Bankruptcy Code” means The Bankruptcy Reform Act of 1978 (Pub. L. No. 95 598;
11 U.S.C.), as amended or supplemented from time to time, or any successor statute, and any and all
rules and regulations issued or promulgated in connection therewith.

     “Base Rate” means at the time any determination thereof is to be made, the fluctuating
per annum rate of interest then most recently announced by the Bank as its “Base Rate” on
commercial loans. The parties hereto understand and acknowledge that the Base Rate is a rate set
by the Bank based upon various factors, including the Bank’s costs and desired return, general
economic conditions and other factors, and is used as a reference point for pricing some loans.
The Bank may price loans at, above or below the Base Rate. Any change in the Base Rate shall take
effect hereunder as of and on the opening of business on the date specified in the announcement of
such change. A certificate in writing by the Cashier or any Vice President of the Bank as to the
Base Rate as of any date shall be prima facie evidence of such fact.

     “Beneficiary” means John Arrillaga, Trustee u/t/a dated 7/20/77 and Richard T. Peery,
Trustee u/t/a dated 7/20/77, or their respective successor trustees under the respective trust
agreements.

     “Borrower” has the meaning set forth in the preamble hereto.

     “Borrower Authorized Representative” means any officer of the Borrower or the person
or persons at the time designated to act on behalf of the Borrower by a written certificate signed
by the Borrower and approved by the Bank.

     “Business Day” means any day other than a Saturday, a Sunday, or a day on which
commercial banks in the City of Los Angeles, California are authorized or required by law or
executive order or decree to close.

     “Certificates of Deposit” means those certain certificates of deposit issued by Bank
to Borrower in aggregate amount of One Million Dollars and all replacements, renewals and proceeds
thereof, as described in the Supplemental Letter between Bank and Borrower of even date herewith.

     “Closing Date” means December 15, 2005.

     “Collateral” means the Account (including all cash, securities and investments
(including Approved Investments) from time to time therein or credited thereto), the Certificates
of Deposit, all products and proceeds thereof and all other property and assets of Borrower that
Bank is now or hereafter granted a Lien upon as security for the Obligations.

     “Custodial Account Agreement” means the custodial account agreement dated November 30,
2005 between Borrower and Securities Intermediary.

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     “Date of Issuance” has the meaning assigned to that term in Section 2.2.

     “Default” means an event which after the lapse of time or the giving of notice, or
both, would constitute an Event of Default.

     “Default Rate” has the meaning assigned to that term in Section 2.5.

     “ERISA” means the Employee Retirement Income Security Act of 1974, as amended from
time to time, including any rules and regulations promulgated thereunder.

     “Event of Default” means an event described in Section 6.1.

     “Expenses” means (i) all expenses of the Bank paid or incurred in connection with its
due diligence and investigation of the Borrower, including appraisal, filing, recording,
documentation, publication and search fees and other such expenses, and all reasonable attorneys’
fees and expenses (including reasonable attorneys’ fees incurred pursuant to proceedings arising
under the Bankruptcy Code) incurred in connection with the structuring, negotiation, drafting,
preparation, execution and delivery of this Agreement, the Related Documents, and any and all other
documents, instruments and agreements entered into in connection herewith; (ii) all expenses of the
Bank, including reasonable attorneys’ fees and expenses (including reasonable attorneys’ fees
incurred pursuant to proceedings arising under the Bankruptcy Code) paid or incurred in connection
with the negotiation, preparation, execution and delivery of any waiver, forbearance, consent,
amendment or addition to this Agreement or any Related Document, or the termination hereof and
thereof; (iii) all costs or expenses paid or advanced by the Bank which are required to be paid by
the Borrower under this Agreement or the Related Documents, including taxes and insurance premiums
of every nature and kind of the Bank, and (iv) during existence of an Event of Default occurs, all
expenses paid or incurred by the Bank, including reasonable attorneys’ fees and expenses (including
reasonable attorneys’ fees incurred pursuant to proceedings arising under the Bankruptcy Code),
costs of collection, suit, arbitration, judicial reference and other enforcement proceedings, and
any other out-of-pocket expenses incurred in connection therewith or resulting therefrom, whether
or not suit is brought, or any other document, instrument or agreement entered into in connection
herewith in the nature of a workout.

     “Expiration Date” means the date on which the Letter of Credit A terminates in
accordance with its terms.

     “Federal Funds Rate” means a fluctuating rate of interest per annum equal to the rate
at which the Bank can buy overnight federal funds from the Federal Reserve Bank of New York. Each
change in the Federal Funds Rate shall take effect simultaneously with the corresponding change or
changes in such rate.

     “Fee Rate” means: (a) with respect to Letter of Credit A, one-half percent (1/2%) per
annum; and (b) with respect to Letter of Credit B and Letter of Credit C, one percent (1%) per
annum.

     “GAAP” means generally accepted accounting principles set forth in the opinions and

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pronouncements of the Accounting Principles Board, the American Institute of Certified Public
Accountants and the Financial Accounting Standards Board, or in such other statements by such other
entity as may be in general use by significant segments of the accounting profession as in effect
on the Date of Issuance.

     “Governing Body” of any specified Person means the board of directors or board of
trustees of such Person or any duly authorized committee of that board, or if there be no board of
trustees or board of directors, then the person or body that pursuant to law or the Organizational
Documents of such Person, is vested with powers similar to those vested in a board of trustees or a
board of directors.

     “Governmental Authority” means any foreign Governmental Authority, the United States
of America, any state of the United States and any political subdivision of any of the foregoing,
and any agency, department, commission, board, bureau or court or other judicial or administrative
tribunal having jurisdiction over the Bank, the Borrower, the Bond Issuer or any of their
respective Property.

     “Guarantee” by any Person means any obligation, contingent or otherwise, of such
Person directly or indirectly guaranteeing any Debt of any other Person and, without limiting the
generality of the foregoing, any obligation, direct or indirect, contingent or otherwise, of such
Person (i) to purchase or pay (or advance or supply funds for the purchase or payment of) such Debt
(whether arising by virtue of partnership arrangements, by agreement to keep-well, to purchase
assets, goods, securities or services, to take-or-pay, or to maintain financial statement
conditions or otherwise), (ii) entered into for the purpose of assuring in any other manner the
obligee of such Debt of the payment thereof or to protect such obligee against loss in respect
thereof (in whole or in part) or (iii) with respect to any letter of credit issued for the account
of such other Person or as to which such other Person is otherwise liable for reimbursement of
drawings, provided that the term “Guarantee” shall not include (i) endorsements for collection or
deposit in the ordinary course of business, or (ii) performance or completion guarantees. The term
“Guarantee” used as a verb has a corresponding meaning.

     “Interior Improvements” has the meaning given it in the Construction Agreements
Related to Lease Agreements executed between Borrower and Beneficiary as of May 16, 2005 build-out
of the shell buildings located at 6800 and 6900 Dumbarton Circle, Fremont, California.

     “Lease” or “Lease Agreement” means that certain Lease Agreement dated May 16,
2005 between Borrower and Beneficiary related to the lease by Borrower from Beneficiary of a
certain 109,786 square foot two story building located at 6900 Dumbarton Circle, Fremont,
California, and that certain Lease Agreement dated May 15, 2005 between Borrower and Beneficiary
related to the lease by Borrower from Beneficiary of a certain 109,786 square foot building located
at 6800 Dumbarton Circle, Fremont, California.

     “Legal Requirement” means any law, statute, ordinance, decree, requirement, order,
judgment, rule or regulation (or interpretation of any of the foregoing) of, and the terms of any
license or permit issued by, any Governmental Authority.

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     “Letter of Credit(s), “Letter of Credit A”, “Letter of Credit B” and “Letter of Credit
C” each have the meanings set forth in Section 2.1 hereof.

     “Lien” means any mortgage, pledge, charge, encumbrance, security interest, collateral
assignment or other lien or restriction of any kind, whether based on common law, constitutional
provision, statute or contract, and shall include reservations, exceptions, encroachments,
easements, rights-of-way, covenants, conditions, restrictions, leases and other title exceptions.

     “Material Adverse Effect” means a materially adverse effect on (i) the business,
assets, liabilities, operations or condition (financial or otherwise) of the Borrower, (ii) the
validity or enforceability of, or the authority or ability of the Borrower to perform its
obligations under, this Agreement or any of the other Related Documents to which it is a party or
to consummate any of the transactions contemplated hereby or thereby, or (iii) the rights of the
Bank hereunder or under the Related Documents (including the pledge of the Collateral hereunder and
the priority of the Liens created hereby or by any Related Document).

     “Obligations” means all indebtedness of Borrower to Bank hereunder, interest thereon
and other obligations of the Borrower to the Bank arising under this Agreement.

     “Officer’s Certificate” of any specified Person means a certificate signed by the
Chairman of the Governing Body, President, Vice President or Treasurer of such Person or any other
officer authorized by resolution of such Person (or in the case of any Person that is not a
corporation, by the managing partner or other Person in which the power to act on behalf of such
Person is vested by law, the Organizational Documents of such Person or by subsequent action of its
Governing Body), and delivered to the Bank.

     “Organizational Documents” means with respect to each Person that is a trust, the
declaration of trust establishing such trust; with respect to a Person that is a corporation, the
certificate of incorporation or articles of incorporation and by-laws of such corporation; with
respect to a Person that is a limited liability company, the certificate of formation or articles
of organization, and the limited liability company agreement or operating agreement, of such
limited liability company; and, with respect to a Person that is a partnership, the partnership
agreement establishing such partnership; in each case including any and all modifications thereof
as of the date of the document referring to such Organizational Document and any and all future
modifications thereof.

     “Permitted Encumbrance” means Liens on assets and properties of Borrower other than the
Collateral:

     (a) in favor of carriers, warehousemen, mechanics, and materialmen granted in the ordinary
course of business for amounts not overdue or being contested in good faith by appropriate
proceedings and for which adequate reserves have been set aside on Borrower’s books;

     (b) made in the ordinary course of business in connection with workers’ compensation,
unemployment insurance or other forms of governmental insurance or benefits, or to secure tenders,
statutory obligations, bids, self insurance surety bond or performance bonds or

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similar obligations entered in the ordinary course of business;

     (c) judgment liens with respect to judgments being contested in good faith which do not
otherwise result in an Event of Default under Section 5.2(g) hereof;

     (d) easements, rights of way, zoning restrictions and minor defects or irregularities in title
which do not materially interfere with the value or use of the property to which such Liens are
attached;

     (e) Liens for taxes not at the time delinquent or thereafter payable without penalty or being
contested by appropriate proceedings and for which adequate reserves have been established on the
books of Borrower;

     (f) Liens to secure payment of workers’ compensation, employment insurance, old-age pensions,
social security, and other like obligations, or to secure the performance of tenders, statutory
obligations, surety, bid and appeal bonds, bids, leases, government contracts, trade contracts,
performance and return-of-the money bonds and similar obligations incurred in the ordinary course
of business; and

     (g) Liens in favor of other financial institutions arising in connection with Borrower’s
deposit or investments accounts held at such institutions to secure fees and charges in connection
with said accounts.

     “Person” means an individual, a corporation, a partnership, an association, a joint
venture, a trust, an unincorporated organization or any other entity or organization, including a
government or political subdivision or an agency or instrumentality thereof

     “Related Documents” has the meaning assigned to that term in Section 2.9.

     “Securities Intermediary” means Comerica Bank, acting through its institutional trust
department, in its capacity as holder and administrator of the Account.

     “State” means the State of California.

     “Stated Termination Date” means: (a) with respect to Letter of Credit A, May 30, 2009;
(b) with respect to Letter of Credit B and Letter of Credit C, January 29, 2021.

     “Taxes” means all income, stamp or other taxes, duties, levies, imposts, charges,
assessments, fees, deductions or withholdings, now or hereafter imposed, levied, collected,
withheld or assessed by any Governmental Authority, and all interest, penalties or similar
liabilities with respect thereto.

     Section 1.2 Computation of Time Periods. In this Agreement, in the computation of a
period of time from a specified date to a later specified date, the word “from” means “from and
including” and the words “to” and “until” each mean “to but excluding”.

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     Section 1.3 Accounting Terms. All accounting terms not specifically defined herein
shall be construed in accordance with GAAP in a manner consistently applied, except as otherwise
stated herein.

     Section 1.4 Interpretation. The following rules shall apply to the construction of
this Agreement unless the context requires otherwise: (a) the singular includes the plural and the
plural, the singular; (b) words importing any gender include the other gender; (c) references to
statutes are to be construed as including all statutory provisions consolidating, amending or
replacing the statute to which reference is made; (d) references to “writing” include printing,
photocopy, typing, lithography and other means of reproducing words in a tangible visible form; (e)
the words “including,” “includes” and “include” shall be deemed to be followed by the words
“without limitation”; (f) references to articles, sections (or subdivisions of sections), exhibits,
appendices, annexes or schedules are to those of this Agreement unless otherwise indicated; (g)
references to agreements and other contractual instruments shall be deemed to include all
subsequent amendments and other modifications to such instruments, but only to the extent that such
amendments and other modifications are permitted or not prohibited by the terms of this Agreement;
(h) references to Persons include their respective permitted successors and assigns; and (i)
headings herein are solely for the convenience of reference and shall not constitute a part of this
Agreement nor shall they affect its meaning, construction or effect.

     All times given herein shall refer to Pacific Standard time or Pacific Daylight time, as
applicable, unless otherwise specified.

ARTICLE II

AMOUNT AND TERMS OF THE LETTER OF CREDIT

     Section 2.1 The Letters of Credit. The Bank agrees, on the terms and conditions
hereinafter set forth, to issue and deliver the Irrevocable Standby Letters of Credit in the form
of the two letters of credit attached as Exhibit A (referred to individually and together herein as
“Letter of Credit A”), Exhibit B (“Letter of Credit B”) and Exhibit C (“Letter of Credit C”, called
together with Letter of Credit A and Letter of Credit B, the “Letters of Credit” and each referred
to individually as a “Letter of Credit”) in favor of the Beneficiary on the Date of Issuance each
expiring on its Stated Termination Date, (unless renewed as hereinafter provided) and in the face
amount of: (a) $23,000,000 and $11,000,000 (i.e., $34,000,000 in aggregate), in the case of Letter
of Credit A, (b) $500,000 in the case of Letter of Credit B; and (c) $500,000 in the case of Letter
of Credit C.

     Section 2.2 Issuing the Letter of Credit. The Letters of Credit shall be issued on
the date the applicable conditions set forth in Article III hereof shall be fulfilled (the
“Date of Issuance”). Borrower may, from time to time hereafter (so long as no Event of
Default at the time exists and with the written consent of Beneficiary, in form satisfactory to
Bank) request amendments to Letter of Credit A for the purpose of decreasing the amount available
for drawing thereunder, provided that, (i) such requests shall not be made more frequently than
monthly and shall be delivered to Bank in writing not less than five (5) Business Days prior to the
proposed effective date of such reduction, (ii) each such requested reduction shall be in an amount
not less than One Million Dollars ($1,000,000), (iii) together with such request, Borrower shall
deliver to

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Bank such evidence as Bank shall require that, the aggregate amount of reductions of Letter of
Credit A (after giving effect to such requested reduction) will not exceed the aggregate amount of
cash payments made by Borrower in payment of the costs of the Interior Improvements as of the date
for such reduction, and (iv) Bank’s obligation to issue such reduction shall be subject to payment
to Bank, prior to the effective date of such reduction, of an amendment fee in an amount determined
by Bank.

     Section 2.3 Fees.

          (a) The Borrower hereby agrees to pay or cause to be paid to the Bank non-refundable,
fully-earned fees in the amount of the Fee Rate with respect to each Letter of Credit multiplied by
the face amount of the respective Letters of Credit. Such fees shall be payable annually in
advance on the Date of Issuance and on each anniversary of the Date of Issuance.

          (b) The Borrower hereby agrees to pay to the Bank, upon each amendment of a Letter of Credit,
an amendment fee to be in amount determined by the Bank in connection therewith.

          (c) The Borrower hereby agrees to pay to the Bank, upon each drawing under the Letter of
Credit in accordance with its terms, a negotiation fee in amount equal to the greater of (i) 1/8%
of the amount of such drawing, or (ii) $500.

          (d) Any amount of fees payable by the Borrower to the Bank, that is not paid when due, shall
bear interest, from the date such amount of fees was due until the date of payment in full, at the
Default Rate, payable promptly on demand and on the date of payment in full.

     Section 2.4 Reimbursement. The Borrower hereby agrees to pay to the Bank, (a) any
amount drawn under any Letter of Credit, immediately after (and on the same Business Day as) such
drawing, plus (b) interest at the Default Rate payable on demand and on the date of payment in full
on any amount remaining unpaid by the Borrower to the Bank, from the date any such amount becomes
payable until payment in full.

     Section 2.5 Default Rate. Any sum payable by the Borrower to the Bank hereunder that
is not paid when due shall bear interest from the date such amount becomes due until the date of
payment in full, at a rate per annum (the “Default Rate”) equal to the Bank Rate for such
day plus two percent (2.00%) per annum, which interest shall be payable on demand and on the date
of payment in full, but if no demand is made, then monthly in arrears. Any sum payable by the
Borrower to the Bank hereunder upon the occurrence or during the continuance of any Default or
Event of Default hereunder shall bear interest from the date of the occurrence of such event until
such time as the Default, Event of Default or event of default is cured to the satisfaction of the
Bank, at the Default Rate, which interest shall be payable on demand and on the date of payment in
full, but if no demand is made, then monthly in arrears as set forth above.

     Section 2.6 Increased Costs. If any law, regulation or change in any law or
regulation or in the interpretation thereof or any ruling, decree, judgment, guideline, directive
or recommendation (whether or not having the force of law) by any regulatory body, court, central

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bank or any administrative or Governmental Authority charged or claiming to be charged with
the administration hereof (including, without limitation, a request or requirement that affects the
manner in which the Bank allocates capital resources to its commitments, including its obligations
hereunder or under any Letter of Credit) shall either (i) impose upon, modify, require, make or
deem applicable to the Bank or any of its affiliates, subsidiaries any reserve requirement, special
deposit requirement, insurance assessment or similar requirement against or affecting any Letter of
Credit or this Agreement or (ii) subject the Bank or any of its affiliates, subsidiaries to any
tax, charge, fee, deduction or withholding of any kind whatsoever in connection with any Letter of
Credit or this Agreement or change the basis of taxation of the Bank or any of its affiliates,
subsidiaries (other than a change in the rate of tax based on the overall net income of the Bank or
such affiliate or subsidiary) in connection with any Letter of Credit or this Agreement or (iii)
impose any condition upon or cause in any manner the addition of any supplement to or increase of
any kind to the Bank’s or any affiliate’s or subsidiary’s capital or cost base for issuing,
maintaining, or participating in any Letter of Credit or this Agreement that results in an increase
in the capital requirement supporting such obligations, or (iv) impose upon, modify, require, make
or deem applicable to the Bank or any of its affiliates or subsidiaries any capital requirement,
increased capital requirement or similar requirement, such as the deeming of any Letter of Credit
or this Agreement to be an asset held by the Bank or any of its affiliates, subsidiaries or
Participants for capital adequacy calculation or other purposes (including, without limitation, a
request or requirement that affects the manner in which the Bank allocates capital resources to its
commitments including its obligations hereunder or under any Letter of Credit), and the result of
any events referred to in (i), (ii), (iii) or (iv) above shall be to increase the costs in any way
to the Bank or any affiliate, subsidiary of issuing or maintaining in any Letter of Credit or this
Agreement or reduce the amount payable by the Borrower hereunder or reduce the rate of return on
capital, as a consequence of the issuing or maintaining or participating in the Letter of Credit or
this Agreement, to a level below that which the Bank, its affiliates or subsidiaries could have
achieved but for such events; then and in such event the Borrower shall, promptly upon receipt of
written notice to the Borrower by the Bank of such increased costs and/or decreased benefits, pay
to the Bank all such additional amounts as, in the Bank’s or any affiliate’s or subsidiary’s sole
good faith calculation as allocated to the Letter of Credit, shall be sufficient to compensate it
for all such increased costs and/or decreased benefits, all as certified by the Bank in said
written notice to the Borrower. Such certification shall be conclusive and binding on the parties
hereto, absent manifest error. In determining such amount, the Bank or any affiliate, subsidiary
or Participant may use any reasonable averaging or attribution methods.

     Section 2.7 Payments and Computations. The Borrower shall make or arrange to make
each payment hereunder on the day when due in lawful money of the United States of America to the
Bank (i) at its address referred to in Section 7.1 in same day funds. Payments received after 3:00
p.m. on any day shall be deemed to be received on the next Business Day. The Borrower hereby
authorizes the Bank, if and to the extent payment is not made when due hereunder, to charge from
time to time against any of the Borrower’s accounts with the Bank any amount so due. Computations
of the Base Rate, Federal Funds Rate, the Bank Rate, the Default Rate and of any fees or
commissions hereunder shall be made by the Bank on the basis of a year of 360 days for the actual
number of days (including the first day but excluding the last day) elapsed. Whenever any payment
to be made hereunder shall be stated to be due on a day that is

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not a Business Day, such payment shall be made on the next succeeding Business Day, and such
extension of time shall in such case be included in the computation of payment of interest, fee or
commission, as the case may be.

     Section 2.8 Evidence of Debt. The Bank shall maintain in accordance with its usual
practice an account or accounts evidencing the Obligations of the Borrower resulting from any
drawing under the Letter of Credit and the amounts of principal, interest and fees payable and paid
from time to time hereunder. Absent manifest error, in any legal action or proceeding in respect
of this Agreement, the entries made in such account or accounts shall be conclusive evidence of the
existence and amounts of the obligations of the Borrower therein recorded.

     Section 2.9 Obligations Absolute. The payment obligations of the Borrower under this
Agreement shall be unconditional and irrevocable, and shall be paid strictly in accordance with the
terms of this Agreement under all circumstances, including, without limitation, the following
circumstances:

     (i) any lack of validity or enforceability of this Agreement, any Letter of
Credit, the Account Pledge Agreement, Account Control Agreement, Custodial Account
Agreement any financing statement or any other agreement or instrument relating
hereto or thereto (collectively, the “Related Documents”);

     (ii) any amendment or waiver of or any consent to or departure from all or any
of the Related Documents or any other document;

     (iii) the existence of any claim, set-off, defense or other right that the
Borrower may have at any time against Beneficiary, Securities Intermediary, or any
beneficiary, or transferee, of any Letter of Credit, the Bank, or any other person
or entity, whether in connection with this Agreement, the transactions contemplated
herein or in any other Related Document, or any unrelated transaction;

     (iv) any statement or any other document presented under any Letter of Credit
proving to be forged, fraudulent, invalid or insufficient in any respect or any
statement therein being untrue or inaccurate in any respect;

     (v) payment by the Bank under a Letter of Credit against presentation of a
draft or certificate which does not comply with the terms of such Letter of Credit;
or

     (vi) any other circumstances or happening whatsoever, whether or not similar to
any of the foregoing.

     Section 2.10 Security. All amounts payable under this Agreement are secured by the
Collateral as defined in the Account Pledge Agreement (including the Account and Certificates of
Deposit). The Bank is hereby authorized to file one or more financing statements (including
fixture filings), continuation statements, or other documents for the purpose of perfecting,
confirming, continuing, enforcing or protecting the Lien and security interest granted by the

Page 10

 

Borrower, without the signature of the Borrower, and naming the Borrower as a debtor and the
Bank as secured party.

ARTICLE III

CONDITIONS OF ISSUANCE

     Section 3.1 Conditions Precedent to Issuance of the Letter of Credit. The obligation
of the Bank to issue the Letter of Credit is subject to the condition precedent that the Bank shall
have received on or before the Date of Issuance the following, each dated as of the Date of
Issuance (unless specified otherwise below), in form and substance reasonably satisfactory to the
Bank:

          (a) This Agreement. This Agreement, duly executed by the Borrower.

          (b) Borrower Documents. (i) Certified copies of the Organizational Documents of the
Borrower, (ii) certificates from the State as to the due incorporation and good standing of the
Borrower, (iii) certificates from the Franchise Tax Board of the State as to the good standing of
the Borrower, and (iv) certified copies of all resolutions and proceedings taken by the Board of
Directors of the Borrower or any duly authorized committee thereof authorizing and approving the
execution, delivery and performance of this Agreement, any other Related Document to which the
Borrower is a party, and the transactions contemplated hereby and thereby, certified by a Borrower
Authorized Representative as being in full force and effect on and as of the Date of Issuance.

          (c) Representations and Warranties True: No Default. On the Date of Issuance each
representation and warranty on the part of the Borrower contained in any Related Document to which
the Borrower is a party is true and correct in all material respects on and as of the Date of
Issuance as though made on and as of such date and no Default or Event of Default has occurred and
is continuing or could result from the execution and delivery of such Related Documents or the
issuance of the Letter of Credit.

          (d) Borrower Incumbency Certificate and Signature Verification. An incumbency
certificate of the Borrower with respect to the officers who are authorized to sign the Related
Documents to which the Borrower is a party on behalf of the Borrower indicating true signatures of
each such officer signing such Related Documents.

          (e) Borrower Certificate. A certificate of the Borrower dated the Date of Issuance,
to the effect that (i) each representation and warranty on the part of the Borrower contained in
any Related Document to which the Borrower is a party is true and correct in all materials respects
on and as of the Date of Issuance as though made on and as of such date, and (ii) that no Default
or Event of Default has occurred and is continuing or could result from the execution and delivery
of such Related Documents or the issuance of the Letter of Credit.

          (f) Fees Payable. Payment to the Bank of all fees and Expenses payable by the
Borrower pursuant to Sections 2.3 and 7.7 hereof.

Page 11

 

          (g) Financing Statements. Evidence that any financing statements or agreements
necessary to provide for a valid and perfected first priority Lien on and security interest in the
Collateral in favor of the Bank subject to no other Liens, other than Permitted Encumbrances.

          (h) Searches. Copies of recent searches, in form and substance satisfactory to the
Bank, of all effective UCC financing statements and fixture filings and all judgment and tax lien
filings which may have been made with respect to any personal or mixed property of the Borrower,
together with copies of all such filings disclosed by such search, and UCC termination statements
duly executed by all applicable Persons for filing in all applicable jurisdictions as may be
necessary to terminate any effective UCC financing statements or fixture filings disclosed in such
search (other than any such financing statements or fixture filings in respect of Liens permitted
to remain outstanding pursuant to the terms of this Agreement).

          (i) Collateral. Confirmation by Bank that Approved Investments with fair market
values not less than $37,780,000 are in the Account, that the Certificates of Deposit have been
established with Bank and that all steps determined by Bank to be necessary to perfect its Lien al
of the foregoing have been completed to Bank’s satisfaction.

          (j) Related Documents. Receipt by the Bank of the Related Documents, duly executed
and in form and substance reasonably satisfactory to the Bank.

          (k) Use of Letters of Credit. Such confirmation of Bank may require demonstrating:
(i) Letter of Credit A shall be utilized by Beneficiary solely as security for Borrowers
obligations to complete Interior Improvements and shall not secure, in any part, any rental
obligations under the Lease, and (ii) that Letter of Credit B and Letter of Credit C will be the
sole security granted to Beneficiary for rental obligations under the Lease.

          (l) Other Documents. Such other documents and certificates as the Bank or its counsel
shall have reasonably requested.

     Section 3.2 Additional Conditions Precedent to Issuance of the Letter of Credit. The
obligation of the Bank to issue the Letter of Credit shall be subject to the further conditions
precedent that on the Date of Issuance the following statements shall be true and the Bank shall
have received an Officer’s Certificate from the Borrower, dated the Date of Issuance, stating that:

     (i) The representations and warranties of the Borrower contained in Section 4.1
of this Agreement and in any other Related Document to which the Borrower is a
party, are true and correct in all material respects on and as of the Date of
Issuance of the Letter of Credit as though made on and as of such date;

     (ii) No Default or Event of Default has occurred and is continuing or could
result from the execution and delivery of the Related Documents to which the
Borrower is a party or the issuance of the Letter of Credit; and

Page 12

 

     (iii) True, complete (including all exhibits, attachments, schedules,
amendments or supplements thereto) and executed counterparts of the Related
Documents have been delivered to the Bank and the Related Documents have not been
modified, amended or rescinded, and are in full force and effect as of the Date of
Issuance.

ARTICLE IV

REPRESENTATIONS AND WARRANTIES

     Section 4.1 Representations and Warranties. To induce the Bank to enter into this
Agreement and issue the Letter of Credit, the Borrower represents and warrants to the Bank as of
the Date of Issuance and as of any date on which the Bank honors a draw under the Letter of Credit
that:

          (a) The Borrower is a corporation duly organized, validly existing and in good standing under
the laws of the State and is in good standing and duly licensed in all other jurisdictions in which
the conduct of its business requires it to be so qualified, except where the failure to be so
qualified would not reasonably be expected to have a Material Adverse Effect. The Borrower has all
requisite corporate power and authority to conduct its business, to own its Property, and to
execute and deliver and perform all of its obligations under this Agreement and the Related
Documents to which it is a party.

          (b) The execution, delivery and performance by the Borrower of this Agreement and the Related
Documents to which it is a party are within the Borrower’s corporate powers, have been duly
authorized by all necessary corporate action, and do not, and will not, contravene (i) any
provision of the Organizational Documents of the Borrower, (ii) any Legal Requirements applicable
to the Borrower or its Property; or (iii) any material contractual restriction binding on or
affecting the Borrower or its Property, and do not result in or require the creation of any
prohibited Lien, security interest or other charge or encumbrance upon or with respect to its
Property or its revenues.

          (c) No order, consent, permit, authorization or approval or other action by, and no notice to
or filing with, any Governmental Authority is required for the due execution, delivery and
performance by the Borrower of this Agreement or any other Related Document to which the Borrower
is a party, except as have been duly obtained or made and are in full force and effect.

          (d) Each of this Agreement and the other Related Documents to which the Borrower is a party is
and will be the legal, valid and binding obligation of the Borrower enforceable against the
Borrower in accordance with their respective terms, except as such enforceability may be limited by
bankruptcy, insolvency, reorganization, moratorium or similar laws affecting creditors’ rights
generally and by general principles of equity (regardless of whether such enforceability is
considered in a proceeding in equity or at law).

          (e) Except as disclosed on Schedule 4.1(e), there is no pending or, to the Borrower’s
knowledge, threatened action, investigation or proceeding before any court,

Page 13

 

governmental agency or arbitrator against or affecting the Borrower or its Property or its
revenues that would be reasonably expected to have a Material Adverse Effect.

          (f) The Borrower has filed all income tax returns and all other material tax returns that are
required to be filed by the Borrower by the date due, and has paid all taxes due pursuant to such
returns or pursuant to any assessments received by the Borrower, other than taxes or assessments
being contested by the Borrower in good faith by appropriate proceedings. The charges, accruals
and reserves on the books of the Borrower in respect of taxes or other governmental charges are
adequate.

          (g) In addition to the representations and warranties contained in this Section 4.1, all
representations and warranties contained in any other Related Document to which the Borrower is a
party or in any agreement, document, instrument or certificate delivered by or on behalf of the
Borrower in connection with the transactions contemplated hereby and thereby shall constitute
representations and warranties made by the Borrower hereunder.

          (h) All representations and warranties made by Borrower herein shall survive the delivery of
this Agreement, and any investigation at any time made by or on behalf of the Bank shall not
diminish its rights to rely thereon. All statements made by Borrower contained in any certificate,
report, document or other instrument delivered by or on behalf of the Borrower under or pursuant to
this Agreement or the Related Documents to which it is a party or in connection with the
transactions contemplated hereby shall constitute representations and warranties made by the
Borrower hereunder. All information submitted to the Bank by or on behalf of the Borrower in
connection with the transactions contemplated hereunder was, to the best of the Borrower’s
knowledge, information and belief, accurate and complete as of the date thereof and did not contain
any misstatement of fact, and the Borrower has not failed to disclose to the Bank any information
known to the Borrower, the substance of which could have a Material Adverse Effect (it being
recognized by Bank that the projections and forecasts provided by Borrower in good faith based upon
reasonable assumptions are not to be viewed as facts and that actual results during the periods
covered by such projections and forecasts may differ from the projected or forecast results).

          (i) The obligations of the Borrower under this Agreement are not in violation of the
Organizational Documents of the Borrower.

          (j) The Borrower has good and marketable title to all of its assets and properties (including
the Collateral). The Collateral is free and clear of all Liens other than the Liens thereon
granted in favor of Bank. To the best of Borrower’s knowledge, upon issuance of the Letters of
Credit hereunder, Borrower shall have complied in all material respects with all obligations under
the Lease Agreements and all the Lease Agreements are in full force and effect. The Borrower
enjoys peaceful and undisturbed possession under the Lease Agreements.

          (k) The Borrower is not in violation of or default under (and no event has occurred that with
the lapse of time or notice of action by a third party could result in a default under) any (i)
Organizational Documents, (ii) any applicable Legal Requirement, (iii) any applicable judgment or
decree or any instrument evidencing any material indebtedness or under

Page 14

 

any material agreement relating thereto, or (iv) any material mortgage, deed of trust,
security agreement, lease, franchise or other material agreement or other instrument to which the
Borrower is a party or by which the Borrower or any of its property is subject or bound, except to
the extent such violation or default would not be reasonably expected to have a Material Adverse
Effect.

          (l) The Borrower carries insurance with reputable insurers in respect of its Property, in such
amounts and against such risks as is customarily maintained by other Persons of similar size
engaged in similar business.

          (m) The Borrower is in compliance with all Legal Requirements in respect of each benefit plan
maintained by the Borrower for their employees, including, but not limited to, all requirements
under ERISA.

          (n) No filings, recordings, registrations or other actions are necessary to create and perfect
the Liens created hereby or by any Related Document; all obligations of the Borrower hereunder are
secured by the Liens created hereby or by any Related Document;

          (o) The Borrower is not engaged in the business of extending credit for the purpose of
purchasing or carrying margin stock (within the meaning of Regulation T, U or X issued by the Board
of Governors of the Federal Reserve System).

ARTICLE V

COVENANTS OF THE BORROWER

     Section 5.1 Affirmative Covenants. So long as a drawing is available under any Letter
of Credit, or the Bank shall have any commitment hereunder, or the Borrower shall have any
obligation to pay any amount to the Bank hereunder, the Borrower shall:

          (a) Preservation of Existence, Etc. Preserve and maintain its legal existence and all
rights, privileges and franchises necessary in the conduct of its business and in the performance
of its obligations under the Related Documents and not dissolve or otherwise discontinue its
existence.

          (b) Compliance with Laws, Etc. Comply with all Legal Requirements applicable to the
Borrower and its assets and properties, non-compliance with which would reasonably be expected to
have a Material Adverse Effect.

          (c) Payment of Taxes, Etc. Pay and discharge before the same shall become delinquent,
(i) all taxes, assessments and governmental charges or levies, if any, imposed upon the Borrower or
its Property or its revenues, and (ii) all lawful claims that, if unpaid, might by law become a
Lien upon its properties or assets; provided, however, that the Borrower shall not be required to
pay and discharge or cause to be paid and discharged any such tax, assessment, governmental charge,
or claim to the extent that the amount, applicability, or validity thereof shall currently be
contested in good faith by appropriate proceedings, so long as no tax sale does occur during such
proceedings and the Borrower shall have established and shall maintain adequate reserves on its
books for the payment of such amounts.

Page 15

 

          (d) Visitation Rights. After occurrence of any Event of Default, during normal
business hours and to the extent not prohibited by law, permit the Bank or any agents or
representatives thereof, to examine and make copies of and abstracts from the records and books of
account of, and visit the properties of the Borrower and to discuss the affairs, finances and
accounts of the Borrower with any of its officers. Keep proper books of record and account, in
which full and correct entries shall be made of all financial transactions relating to the Borrower
and its property and their revenues, in accordance with GAAP in a manner consistently applied.

          (e) Reporting Requirements. Furnish to the Bank the following:

     (i) as soon as possible after becoming aware of the occurrence of an Event of
Default or Default continuing on the date of such statement, written notice from a
Borrower Authorized Representative setting forth details of such Event of Default or
Default and the action that the Borrower proposes to take with respect thereto;

     (ii) as soon as possible after the occurrence of any event that could have a
Material Adverse Effect, written notice from a Borrower Authorized Representative
setting forth details of such event and the action that the Borrower proposes to
take with respect thereto;

     (iii) as soon as available but not later than one hundred twenty (120) after
the end of each fiscal year, a complete copy of Borrower’s audited Financial
Statement, which shall include at least Borrower’s balance sheet as of the close of
such fiscal year, and Borrower’s statement of income and retained earnings and
statement of cash flow for such fiscal year, certified by a certified public
accountant selected by Borrower and satisfactory to the Bank (which will not
unreasonably withhold its approval), which statements shall not be qualified in any
manner;

     (iv) as soon as available but not later than forty five (45) days after the end
of each fiscal quarter of Borrower, Borrower prepared balance sheets and statements
of income and retained earnings and cash flows as of the end of such fiscal quarter,
certified by a Borrower Authorized Representatives;

     (v) so long as Letter of Credit A remains issued and unexpired (an thereafter,
so long as any Obligations related to Letter of Credit A remain outstanding) within
twenty (20) days after the end of each month, (i) Account statements from the
Securities Intermediary and Account Manager showing the status of the Account
(including market values of the Approved Investments then in or credited to the
Account), (ii) investment portfolio reports prepared by the Account Manager with
respect to Borrower’s entire portfolio of cash and investments and (iii) copies of
all material public correspondence and notifications related to the testing and/or
approval process of “My Vax” and or other vaccines and medications under development
by Borrower received by

Page 16

 

Borrower from the United States Food and Drug Administration or Security and
Exchange Commission or other governmental authority;

     (vi) with reasonable promptness, at any time that the Borrower becomes aware of
or has actual knowledge of the existence of any litigation or proceedings before any
Governmental Authority which, if determined adversely in the opinion of the
Borrower, could reasonably be expected to have a Material Adverse Effect, written
notice to the Bank with respect thereto; and

     (vii) such other information respecting the Borrower and the Collateral and the
Borrower’s revenues, as the Bank may from time to time reasonably request.

          (f) Insurance. Maintain, at the Borrower’s expense (and, upon request of Bank,
provide Bank with evidence of);

     (i) insurance on its property with financially sound and reputable insurance
companies against loss and damage in at least the amounts (and with only those
deductibles) customarily maintained, and against such risks (including fire and
other risks insured against by extended coverage) as are typically insured against
in the same general area, by companies of comparable size engaged in the same or
similar business as the Borrower and its subsidiaries;

     (ii) liability insurance in customary amounts for similar companies; and

     (iii) all worker’s compensation, employer’s liability insurance or similar
insurance as may be required under the laws of any state or jurisdiction in which it
may be engaged in business.

          (g) Maintenance of Permits, Etc. Take all necessary and appropriate action to ensure
the continuation in force of all material consents, licenses, permits, orders, decrees, approvals,
authorizations, registrations and filing obtained or made in connection with its properties or its
revenues, this Agreement or the other Related Documents to which the Borrower is a party, or the
acquisition, construction or use of the leasehold under the Lease.

          (h) Maintenance of Properties, Etc. Maintain and preserve of its property that is
used or useful in the conduct of its business in good working order and condition, ordinary wear
and tear excepted.

          (i) Investment Policy and Account Maintenance. Invest, or cause to be invested, all
of Borrowers liquid assets at all times in conformity with the Borrower’s Investment Policy
Guidelines, as revised March 3, 2005 and previously delivered to Bank and with respect to the
Account, cause all funds and assets in or credited to the Account to be invested in Approved
Investments. In the event that, at any time, the amount available for drawing under Letter of
Credit A (plus the amount of any unreimbursed drawings thereunder) exceeds ninety percent (90%) the
aggregate value of Approved Investments in the Account , Borrower shall,

Page 17

 

within four (4) Business Days of such occurrence, cause additional Approved Investments to be
deposited in or credited to the Account, with values sufficient to eliminate such excess.

          (j) Further Assurances. Execute and deliver, or cause to be executed and delivered,
to the Bank from time to time, promptly upon request therefor, any and all other and further
instruments (including correction instruments) that may be reasonably requested by the Bank to cure
any deficiency in the execution and delivery of this Agreement or any Related Document to which it
is a party or more fully to describe particular aspects of any of the Borrower’s agreements and
undertakings provided in this Agreement or any Related Document to which it is a party or so
intended to be, or to perfect the Liens created hereby or by any Related Document.

          (k) Benefit Plans. Cause any benefit plan maintained for its employees to be in
compliance in all material respects with all Legal Requirements applicable thereto, including, but
not limited to, all requirements under ERISA, except for non-compliance which, in aggregate would
not result in a material adverse effect.

          (l) Primary Bank Accounts. Borrower shall use its best efforts to establish its
primary operating accounts with Bank.

          Notwithstanding anything to the contrary above, after the termination or surrender of Letter
of Credit A, and the payment of all Obligations in connection therewith, all of the subsections of
the foregoing Section 5.1, other than subsection 5.1(e), clauses (i), (ii), (iii) (iv), (vi) and
(vii) shall be of no further force and effect and shall be deemed deleted from this Agreement.

     Section 5.2 Negative Covenants. So long as a drawing is available under the Letter of
Credit, or the Bank shall have any commitment with respect thereto, or the Borrower shall have any
obligation to pay any amount to the Bank hereunder, the Borrower will not, without the prior
written consent of the Bank:

          (a) Encumbrances & Liens, Etc. Pledge, assign, grant any security interest in, allow
any Lien to exist on the Collateral (other than to Bank) or with respect to properties or assets of
Borrower, (including without limitation, any Liens in favor of Beneficiary as security for
Borrowers’ obligations under the Lease), other than (a) the Liens created hereby and by any other
Related Document (b) purchase money security interests and capital leases incurred in connection
with the purchase or lease of fixed assets, securing indebtedness incurred in connection with such
purchase or lease (c) Permitted Encumbrances and (d) pledges of and security interests in cash and
securities held by Borrower (other than Collateral) as security for funded indebtedness of
Borrower;

          (b) Sale, Assignment, Transfer or Pledge. Sell, transfer, lease, license or otherwise
dispose of all or any portion of its Property, or any fixed assets or equipment used at, on or in
connection therewith, except for such assets sold, leased or otherwise disposed of: (i) in the
ordinary course of business for at least fair market value; (ii) sales and discounts of accounts
receivable in the ordinary course of business, (iii) due to obsolescence or excessive wear or upon

Page 18

 

determination by the Borrower that such assets are no longer useful or necessary to the
purposes of the Borrower; (iv) sales and exchanges of Collateral in the Account, to the extent
specifically permitted under Section 3 of the Account Control Agreement.

          (c) Account Manager. So long as Letter of Credit A is issued and unexpired, without
prior written consent from Bank, change the account manager for the Account or release Payden &
Rygel from its duties and responsibilities as account manager for the Account.

          Notwithstanding anything to the contrary above, after the termination or surrender of Letter
of Credit A, and the payment of all Obligations related thereto, clauses (b) and (c) of this
Section 5.2 shall be of no further force and effect and shall be deemed deleted from this
Agreement.

ARTICLE VI

EVENTS OF DEFAULT

     Section 6.1 Events of Default. If any of the following events occur, the Bank may do
one or more of the following: declare an Event of Default and exercise any of the remedies set
forth herein. If an event described under the paragraphs set forth in (b) and (c) below, then an
Event of Default shall exist automatically without any action by the Bank and the remedies set
forth in Section 6.2 shall apply:

          (a) Failure by the Borrower to pay when due any Obligation when required to be paid hereunder
or under any other Related Document within three (3) Business Days after written notification to
Borrower of the failure to make payment on the due date for such payment;

          (b) The Borrower shall become or be the subject of any insolvency proceeding or shall file a
petition or other pleading seeking an “order for relief” within the meaning of the United States
Bankruptcy Code or shall file any petition or other pleading seeking any reorganization,
composition, readjustment, liquidation or similar relief for itself under any present or future law
or regulation, or shall seek or consent to or acquiesce in the appointment of any trustee, receiver
or liquidator of the Borrower, or of substantially all of its assets, or shall make a general
assignment for the benefit of creditors, or shall admit in writing its inability to pay its debts
generally as they become due; or

          (c) If a petition or other pleading shall be filed against the Borrower, seeking an “order for
relief” within the meaning of the United States Bankruptcy Code or any reorganization, composition,
readjustment, liquidation or similar relief under any present or future law or regulation and shall
remain undismissed or unstayed for an aggregate period of sixty (60) days (whether or not
consecutive), or if, by an order or decree of a court of competent jurisdiction, the Borrower shall
become the subject of an “order for relief” within the meaning of the United States Bankruptcy Code
or relief shall be granted under or pursuant to any such petition or other pleading, and such order
or decree continues unvacated or unstayed, on appeal or otherwise, and in effect for a period of
sixty (60) days; or if, by order or decree of such court, there shall be appointed, without the
consent or acquiescence of the Borrower, a trustee in

Page 19

 

bankruptcy or reorganization or a receiver or liquidator of the Borrower, or of all or any
substantial part of the Property of the Borrower, and such order or decree continues unvacated or
unstayed, on appeal or otherwise, and in effect for a period of sixty (60) days; or

          (d) The failure of the Borrower to perform, observe, or comply with any covenants contained in
Sections 5.1(i) or 5.2(a), (b) or (c) of this Agreement; or

          (e) Failure of Borrower to observe or perform the covenants contained in (i) Section 5.1(e) of
this Agreement, and continuance of such failure for a period in excess of five (5) days, or (ii)
any other provision of this Agreement or any Related Document and continuance thereof for a period
of thirty (30) days from the earlier of Borrower’s actual knowledge thereof or written notice by
Bank to Borrower thereof; or

          (f) Any representation or warranty made by the Borrower in connection with this Agreement or
the other Related Documents shall prove to have been materially false when made or deemed made; or

          (g) One or more judgments, decrees or orders for the payment of money in excess of $3,000,000
in aggregate, which is not subject to insurance (or for which the carrier has denied or disputed
coverage other than a routine reservation of rights) shall be rendered against the Borrower and
shall remain unpaid or unstayed for a period in excess of twenty (20) days; or

          (h) Any payment or other material provision of this Agreement or any of the other Related
Documents to which it is a party shall cease to be valid and binding on the Borrower, or the
Borrower denies that it has any or further liability or obligation under this Agreement or any
Related Document; or

          (i) There is a default by the Borrower under any agreement or instrument to which it is a
party relating to any indebtedness in principal amount in excess of Three Million Dollars
($3,000,000) to any Person other than Bank either (i) in failing to pay any installment of
principal or interest on such indebtedness, which default shall not have been waived or excused
within any applicable grace period or (ii) as a result of which any such indebtedness shall have
been accelerated and declared to be due and payable prior to its date of maturity; or

          (j) Any pledge, security interest or Lien created hereby or by any other Related Document to
secure any amount due by the Borrower under this Agreement shall fail to be fully enforceable with
the priority required hereunder or thereunder; or

          (k) A Material Adverse Effect occurs; or

          (l) If, without prior consent of Bank, Dan W. Denney (“Denney”) ceases to be active as the
chief executive officer of Borrower and the Borrower is not actively engaged in identification and
retention of a suitable successor; or

          (m) If at any time (i) the aggregate amount of Borrower’s outstanding Obligations related to
Letter of Credit A plus the undrawn portion of the face amount of Letter of Credit A at any time
exceeds ninety percent (90%) of the fair market value of the Account or (ii)

Page 20

 

the aggregate face amounts of Letter of Credit B and Letter of Credit C exceed the face amount
of the Certificates of Deposit.

     Section 6.2 Remedies Upon an Event of Default. If any Event of Default shall have
occurred and be continuing, the Bank, may (a) declare all amounts outstanding hereunder, all
interest thereon and all other amounts payable hereunder to be forthwith due and payable, whereupon
all principal amounts outstanding hereunder, all interest and all such other amounts shall become
and be forthwith due and payable, without presentment, demand, protest or further notice of any
kind, all of which are hereby expressly waived by the Borrower, and (b) exercise any and all rights
and remedies provided herein, under the Related Documents, at law or in equity; provided,
however, that in the event of an actual or deemed entry of an order for relief with respect
to the Borrower under the United States Bankruptcy Code, and all amounts reimbursable pursuant to
Sections 2.4 and Section 2.5, all interest accrued and unpaid thereon and all other amounts payable
hereunder shall automatically become due and payable, without presentment, demand, protest or any
notice of any kind, all of which are hereby expressly waived by the Borrower. During the pendency
of a Default or Event of Default, all amounts payable under this Agreement shall bear interest at
the Default Rate.

ARTICLE VII

GENERAL PROVISIONS

     Section 7.1 Notices, Etc. All notices and other communications provided for hereunder
shall be in writing (including required copies) and sent by receipt hand delivery (including
Federal Express or other receipted courier service), telex, telecopy, facsimile or regular mail, as
follows:

	 	 	 	 	 	 	 
	if to the Beneficiary:
	 	Peery - Arvillaga	 	 
	 	 	 
	 	 
	 	 	2650 Mission College
Blvd. Ste. 101	 	 
	 	 	 
	 	 
	 	 	Santa Clara, CA	 	 
	 	 	 
	 	 
	 

	 	Attention:	 	 	 	 
	 

	 	 	 	 	 	 
	 

	 	Telephone:	 	408-980-0130 x120	 	 
	 

	 	 	 	 	 	 
	 

	 	Facsimile:	 	408-980-1940	 	 
	 

	 	 	 	 	 	 
	 
	 	 	 	 	 	 
	if to
the Borrower:
	 	Genitope Corporation	 	 
	 	 	525 Penobscot Drive	 	 
	 	 	Redwood City, CA 94062	 	 
	 

	 	Telephone:	 	650-482-2000	 	 
	 

	 	 	 	 	 	 
	 

	 	Facsimile:	 	650-472-2145	 	 
	 

	 	 	 	 	 	 
	 
	 	 	 	 	 	 
	if
to the Bank:
	 	Comerica Bank	 	 
	 	 	Two Embarcadero Center, Suite 300	 	 
	 	 	San Francisco, CA 94111	 	 
	 	 	Attention: Robert Hurley	 	 
	 	 	Telephone: (415) 477-3206	 	 
	 	 	Facsimile: (415) 477-3270	 	 

Page 21

 

or, as to each party, at such other address as shall be designated by such party in a written
notice to the other party. All such notices and communications shall, when delivered or telexed,
telecopied, faxed or mailed, be effective when deposited with the courier, telexed, telecopied,
faxed or mailed respectively, addressed as aforesaid.

     Section 7.2 Survival of Covenants; Successors and Assigns. All covenants, agreements,
representations and warranties made herein and in the certificates delivered pursuant hereto shall
continue in full force and effect so long as the Agreement is in effect and until all obligations
of the Borrower hereunder and under the other Related Documents shall have been paid in full.
Whenever in this Agreement any of the parties hereto is referred to, such reference shall, subject
to the last sentence of this Section 7.2, be deemed to include the successors and assigns of such
party, and all covenants, promises and agreements by or on behalf of the Borrower which are
contained in this Agreement shall inure to the benefit of the successors and assigns of the Bank.
The Borrower may not transfer its rights or obligations under this Agreement without the prior
written consent of the Bank. This Agreement is made solely for the benefit of the Borrower and the
Bank, and no other Person or entity (including, without limitation, the Bond Issuer) shall have any
right, benefit or interest under or because of the existence of this Agreement.

     Section 7.3 Participations. Notwithstanding the foregoing, the Bank shall be
permitted to grant to one or more Participants, a participation or participations in all or any
part of the Bank’s rights and obligations under this Agreement, the Letter of Credit, or any other
Related Document on a participating basis but not as a party to this Agreement (a “Participation”),
without the consent of the Borrower. In the event of any such grant by the Bank of a Participation
to a Participant, whether or not upon notice to the Borrower, the Bank shall remain responsible for
the performance of its obligations hereunder and under the Letter of Credit, and the Borrower shall
continue to deal solely and directly with the Bank in connection with the Bank’s rights and
obligations under this Agreement and under the Letter of Credit. The Borrower agrees that each
such Participant shall, to the extent of its Participation, be entitled to the benefits of this
Agreement as if such Participant were the Bank.

     Section 7.4 Right of Set-Off.

          (a) Upon the occurrence and during the continuance of any Event of Default, the Bank is hereby
authorized at any time and from time to time, to the fullest extent permitted by law, to set off
and apply any and all deposits (general or special, time or demand, provisional or final) at any
time held and other debt at any time owing by the Bank to or for the credit or the account of the
Borrower against any and all of the obligations of the Borrower now or hereafter existing under
this Agreement, irrespective of whether or not the Bank shall have made any demand hereunder.

          (b) The Bank agrees promptly to notify the Borrower after undertaking any such set-off and
application referred to in subsection (a) above, provided that the failure to give such
notice shall not affect the validity of such set-off and application. The rights of the Bank under
this Section are in addition to other rights and remedies (including, without limitation, other
rights of set-off) which the Bank may have.

Page 22

 

     Section 7.5 Liability of Bank: Indemnification. The Borrower hereby indemnities and
holds the Bank harmless from and against all claims, damages, losses, liabilities, costs or
expenses that the Bank may incur or that may be claimed against the Bank by any Person:

          (a) by reason of or in connection with the execution, delivery or performance of this
Agreement, any Letter of Credit or any other Related Document, or any transaction contemplated
thereby or hereby provided, however, that the Borrower shall not be required to
indemnify the Bank pursuant to this Section 7.5 (a) for any claims, damages, losses, liabilities,
costs or expenses to the extent finally determined by a court of competent jurisdiction to have
been caused by the Bank’s gross negligence or willful misconduct; or

          (b) by reason of or in connection with any claim, litigation or other matter involving the
Borrower provided, however, that the Borrower shall not be required to indemnify
the Bank pursuant to this Section 7.5(b) for any claims, damages, losses, liabilities, costs or
expenses to the extent finally determined by a court of competent jurisdiction to have been caused
by the Bank’s gross negligence or willful misconduct; or

          (c) by reason of or in connection with the execution and delivery or transfer of, or payment
or failure to make payment under, any Letter of Credit; provided, however, that the
Borrower shall not be required to indemnify the Bank pursuant to this Section 7.5(c) for any
claims, damages, losses, liabilities, costs or expenses to the extent finally determined by a court
of competent jurisdiction to have been caused by the Bank’s gross negligence or willful misconduct.

               Without prejudice to the survival of any other obligation of the Borrower hereunder, the
indemnities and obligations of the Borrower contained in this Section 7.5 shall survive the payment
in full of amounts payable pursuant to Article II and the termination of the Letter of Credit.

     Section 7.6 Liability of the Bank. The Borrower assumes all risks of the acts or
omissions of the Beneficiary and any other beneficiary or transferee of any Letter of Credit with
respect to its use of any Letter of Credit. Neither the Bank nor any of its officers or directors
shall be liable or responsible for: (a) the use that may be made of any Letter of Credit or any
acts or omissions of the Beneficiary and any other beneficiary or transferee in connection
therewith; (b) the validity, sufficiency or genuineness of documents, or of any endorsement
thereon, even if such documents should prove to be in any or all respects invalid, insufficient,
fraudulent or forged; (c) payment by the Bank against presentation of documents that do not comply
with the terms of the Letter of Credit, including failure of any documents to bear any reference or
adequate reference to the Letter of Credit; or (d) any other circumstances whatsoever in making or
failing to make payment under the Letter of Credit. In furtherance and not in limitation of the
foregoing, the Bank may accept documents that appear on their face to be in order, without
responsibility for further investigation, regardless of any notice or information to the contrary;
provided, that if the Bank shall receive prior written notification from the Borrower that
sufficiently identifies, in the opinion of the Bank, documents to be presented to the Bank that are
not to be honored, the Bank agrees that it will not honor such documents.

Page 23

 

     Section 7.7 Expenses and Taxes. The Borrower will promptly pay all Expenses. In
addition, the Borrower shall pay any and all stamp and other taxes and fees payable or determined
to be payable in connection with the execution, delivery, filing and recording of this Agreement
and the other Related Documents and agrees to save the Bank harmless from and against any and all
liabilities with respect to or resulting from any delay in paying or omission to pay such taxes and
fees.

     Section 7.8 No Waiver; Conflict.

          (a) Neither any failure nor any delay on the part of the Bank in exercising any right, power
or privilege hereunder, nor any course of dealing with respect to any of the same, shall operate as
a waiver thereof, nor shall a single or partial exercise thereof preclude any other or further
exercise thereof or the exercise of any other right, power or privilege. The remedies herein
provided are cumulative, and not exclusive of any remedies provided by law.

          (b) To the extent of any conflict between this Agreement on the one hand and any other Related
Document on the other hand, this Agreement shall control as between the Borrower and the Bank.

     Section 7.9 Modification, Amendment, Waiver, Etc. No modification, amendment or
waiver of any provision of this Agreement shall be effective unless the same shall be in writing
and signed by the parties hereto, and then such waiver or consent shall be effective only in the
specific instance and for the specific purpose given.

     Section 7.10 Dealing with the Borrower. The Bank and its affiliates may accept
deposits from, extend credit to and generally engage in any kind of banking, trust or other
business with the Borrower regardless of the capacity of the Bank hereunder.

     Section 7.11 Severability. Any provision of this Agreement which is prohibited or
unenforceable in any jurisdiction shall, as to such jurisdiction, be ineffective to the extent of
such prohibition or unenforceability without invalidating the remaining provisions hereof or
affecting the validity or enforceability of such provision in any other jurisdiction, and the
remaining portion of such provision and all other remaining provisions hereof will be construed to
render them enforceable to the fullest extent permitted by law.

     Section 7.12 Counterparts. This Agreement may be executed in two or more
counterparts, each of which shall constitute an original, but when taken together shall constitute
but one agreement and any of the parties hereto may execute this Agreement by signing any such
counterpart.

     Section 7.13 Table of Contents; Headings. The table of contents and the Section and
subsection headings used herein have been inserted for convenience of reference only and do not
constitute matters to be considered in interpreting this Agreement.

     Section 7.14 Prior Agreements Superseded. This Agreement shall completely and fully
supersede all prior undertakings or agreements, both written and oral, between the Borrower and

Page 24

 

the Bank relating to the Letter of Credit, including those contained in any commitment letter
between the Bank and the Borrower executed in anticipation of this Agreement.

     Section 7.15 CHOICE OF LAW AND VENUE; JURY TRIAL WAIVER.

          (a) THE VALIDITY OF THIS AGREEMENT AND THE OTHER RELATED DOCUMENTS (UNLESS EXPRESSLY PROVIDED
TO THE CONTRARY IN ANOTHER LOAN DOCUMENT IN RESPECT OF SUCH OTHER RELATED DOCUMENT), THE
CONSTRUCTION, INTERPRETATION, AND ENFORCEMENT HEREOF AND THEREOF, AND THE RIGHTS OF THE PARTIES
HERETO AND THERETO WITH RESPECT TO ALL MATTERS ARISING HEREUNDER OR THEREUNDER OR RELATED HERETO OR
THERETO SHALL BE DETERMINED UNDER, GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH THE INTERNAL LAWS
OF THE STATE OF CALIFORNIA, WITHOUT REGARD FOR PRINCIPLES OF CONFLICTS OF LAWS.

          (b) THE PARTIES AGREE THAT ALL ACTIONS OR PROCEEDINGS ARISING IN CONNECTION WITH THIS
AGREEMENT AND THE OTHER RELATED DOCUMENTS SHALL BE TRIED AND LITIGATED ONLY IN THE STATE AND
FEDERAL COURTS LOCATED IN THE COUNTY OF SANTA CLARA, STATE OF CALIFORNIA, PROVIDED,
HOWEVER, THAT ANY SUIT SEEKING ENFORCEMENT AGAINST ANY COLLATERAL OR OTHER PROPERTY MAY BE
BROUGHT, AT BANK’S OPTION, IN THE COURTS OF ANY JURISDICTION WHERE BANK ELECTS TO BRING SUCH ACTION
OR WHERE SUCH COLLATERAL OR OTHER PROPERTY MAY BE FOUND. THE BORROWER AND THE BANK WAIVE, TO THE
EXTENT PERMITTED UNDER APPLICABLE LAW, ANY RIGHT EACH MAY HAVE TO ASSERT THE DOCTRINE OF FORUM
NON CONVENIENS  OR TO OBJECT TO VENUE TO THE EXTENT ANY PROCEEDING IS BROUGHT IN ACCORDANCE WITH
THIS SECTION.

          (c) THE BORROWER AND THE BANK HEREBY WAIVE THEIR RESPECTIVE RIGHTS TO A JURY TRIAL OF ANY
CLAIM OR CAUSE OF ACTION BASED UPON OR ARISING OUT OF THIS AGREEMENT OR ANY OF THE RELATED
DOCUMENTS OR ANY OF THE TRANSACTIONS CONTEMPLATED HEREIN OR THEREIN, INCLUDING CONTRACT CLAIMS,
TORT CLAIMS, BREACH OF DUTY CLAIMS, AND ALL OTHER COMMON LAW OR STATUTORY CLAIMS. THE BORROWER AND
BANK REPRESENT THAT EACH HAS REVIEWED THIS WAIVER AND EACH KNOWINGLY AND VOLUNTARILY WAIVES ITS
JURY TRIAL RIGHTS FOLLOWING CONSULTATION WITH LEGAL COUNSEL. IN THE EVENT OF LITIGATION, A COPY OF
THIS AGREEMENT MAY BE FILED AS A WRITTEN CONSENT TO A TRIAL BY THE COURT.

     Section 7.16 Reference Provision.

          (a) In the event the Jury Trial Waiver provision contained in Section 7.16(c) is invalid or
unenforceable, the parties elect to proceed under this Judicial Reference Provision.

Page 25

 

          (b) Other than (i) nonjudicial foreclosure of security interests in real or personal property,
(ii) the appointment of a receiver or (iii) the exercise of other provisional remedies (any of
which may be initiated pursuant to applicable law), any controversy, dispute or claim (each, a
"Claim”) between the parties arising out of or relating to this Agreement or any Loan Document,
will be resolved by a reference proceeding in California in accordance with the provisions of
Section 638 et seq. of the California Code of Civil Procedure (“CCP”), or their successor
sections, which shall constitute the exclusive remedy for the resolution of any Claim, including
whether the Claim is subject to the reference proceeding. Except as otherwise provided herein or
in the Related Documents, venue for the reference proceeding will be in the Superior Court or
Federal District Court in the County or District where the real property, if any, is located or in
a County or District where venue is otherwise appropriate under applicable law (the
“Court”).

          (c) The referee shall be a retired Judge or Justice selected by mutual written agreement of
the parties. If the parties do not agree, the referee shall be selected by the Presiding Judge of
the Court (or his or her representative). A request for appointment of a referee may be heard on
an ex parte or expedited basis, and the parties agree that irreparable harm would result if ex
parte relief is not granted. The referee shall be appointed to sit with all the powers provided by
law. Each party shall have one peremptory challenge pursuant to CCP §170.6. Pending appointment
of the referee, the Court has power to issue temporary or provisional remedies.

          (d) The parties agree that time is of the essence in conducting the reference proceedings.
Accordingly, the referee shall be requested to (i) set the matter for a status and trial- setting
conference within fifteen (15) days after the date of selection of the referee, (ii) if
practicable, try all issues of law or fact within ninety (90) days after the date of the conference
and (iii) report a statement of decision within twenty (20) days after the matter has been
submitted for decision. Any decision rendered by the referee will be final, binding and
conclusive, and judgment shall be entered pursuant to CCP §644.

          (e) The referee will have power to expand or limit the amount and duration of discovery. The
referee may set or extend discovery deadlines or cutoffs for good cause, including a party’s
failure to provide requested discovery for any reason whatsoever. Unless otherwise ordered, no
party shall be entitled to “priority” in conducting discovery, depositions may be taken by either
party upon seven (7) days written notice, and all other discovery shall be responded to within
fifteen (15) days after service. All disputes relating to discovery which cannot be resolved by
the parties shall be submitted to the referee whose decision shall be final and binding.

          (f) Except as expressly set forth in this Agreement, the referee shall determine the manner in
which the reference proceeding is conducted including the time and place of hearings, the order of
presentation of evidence, and all other questions that arise with respect to the course of the
reference proceeding. All proceedings and hearings conducted before the referee, except for trial,
shall be conducted without a court reporter, except that when any party so requests, a court
reporter will be used at any hearing conducted before the referee, and the referee will be provided
a courtesy copy of the transcript. The party making such a request shall have the obligation to
arrange for and pay the court reporter. Subject to the referee’s power to

Page 26

 

award costs to the prevailing party, the parties will equally share the cost of the referee
and the court reporter at trial.

          (g) The referee shall be required to determine all issues in accordance with existing case law
and the statutory laws of the State of California. The rules of evidence applicable to proceedings
at law in the State of California will be applicable to the reference proceeding. The referee
shall be empowered to enter equitable as well as legal relief, provide all temporary or provisional
remedies, enter equitable orders that will be binding on the parties and rule on any motion which
would be authorized in a trial, including without limitation motions for summary judgment or
summary adjudication. The referee shall issue a decision at the close of the reference proceeding
which disposes of all claims of the parties that are the subject of the reference. The referee’s
decision shall be entered by the Court as a judgment or an order in the same manner as if the
action had been tried by the Court. The parties reserve the right to appeal from the final
judgment or order or from any appealable decision or order entered by the referee. The parties
reserve the right to findings of fact, conclusions of laws, a written statement of decision, and
the right to move for a new trial or a different judgment, which new trial, if granted, is also to
be a reference proceeding under this provision.

          (h) If the enabling legislation which provides for appointment of a referee is repealed (and
no successor statute is enacted), any dispute between the parties that would otherwise be
determined by reference procedure will be resolved and determined by arbitration. The arbitration
will be conducted by a retired judge or Justice, in accordance with the California Arbitration Act
§1280 through §1294.2 of the CCP as amended from time to time. The limitations with respect to
discovery set forth above shall apply to any such arbitration proceeding.

          (i) THE PARTIES RECOGNIZE AND AGREE THAT ALL DISPUTES RESOLVED UNDER THIS REFERENCE PROVISION
WILL BE DECIDED BY A REFEREE AND NOT BY A JURY, AND THAT THEY ARE IN EFFECT WAIVING THEIR RIGHT TO
TRIAL BY JURY IN AGREEING TO THIS REFERENCE PROVISION. AFTER CONSULTING (OR HAVING HAD THE
OPPORTUNITY TO CONSULT) WITH COUNSEL OF THEIR OWN CHOICE, EACH PARTY KNOWINGLY AND VOLUNTARILY AND
FOR THEIR MUTUAL BENEFIT AGREES THAT THIS REFERENCE PROVISION WILL APPLY TO ANY DISPUTE BETWEEN
THEM WHICH ARISES OUT OF OR IS RELATED TO THIS AGREEMENT OR THE RELATED DOCUMENTS.

[Remainder Of This Page Intentionally Left Blank]

Page 27

 

     IN WITNESS WHEREOF, the Borrower and the Bank have duly executed this Agreement effective as
of the date first above written.

	 	 	 	 	 	 	 
	THE BORROWER:	 	GENITOPE CORPORATION	 	 
	 
	 	 	 	 	 	 
	 

	 	BY:	 	/s/ John Vuko	 	 
	 

	 	 	 	 	 	 
	 

	 	Name:	 	John Vuko	 	 
	 

	 	 	 	 	 	 
	 

	 	Title:	 	CFO	 	 
	 

	 	 	 	 	 	 
	 
	 	 	 	 	 	 
	THE BANK:	 	COMERICA BANK	 	 
	 
	 	 	 	 	 	 
	 

	 	BY:	 	/s/ Robert Hurley	 	 
	 

	 	 	 	 	 	 
	 

	 	Name:	 	Robert Hurley	 	 
	 

	 	 	 	 	 	 
	 

	 	Title:	 	VP	 	 
	 

	 	 	 	 	 	 

Page 28

 

EXHIBIT A, B AND C

FORMS OF IRREVOCABLE LETTER OF CREDIT

Page 29

 

COMERICA BANK HAS PREPARED THIS DRAFT UPON THE REQUEST AND BASED ON INFORMATION SUPPLIED TO IT. NO
REPRESENTATION OR COMMITMENT IS MADE BY ISSUING BANK REGARDING THE ACCURACY OR SUITABILITY OF THIS
DRAFT FOR ITS INTENDED PURPOSE OR THE WILLINGNESS OF ISSUING BANK TO ISSUE THIS LETTER OF CREDIT IN
THIS OR ANY OTHER FORM.

DATE:                                         

BENEFICIARY

THE RICHARD T. PEERY SEPARATE PROPERTY TRUST

AND THE JOHN ARRILLAGA SURVIVOR’S TRUST

2560 MISSION COLLEGE BLVD., SUITE 101

SANTA CLARA, CA. 95054

Construction Security Deposit: 6900 Dumbarton Circle, Fremont, CA (Ardenwood IV-5)

We hereby establish our irrevocable standby letter of credit no. xxxxxx-xx, in your favor for
the account of genitope corporation, 525 penobscot drive, redwood city, ca. 94063 in the amount of
usd$11,000,000.00 (Eleven million u.s. dollars) to expire on may 30, 2009, available by payment of
your draft(s) at sight on us when accompanied by the following documents:

1. A WRITTEN AND DATED STATEMENT ON THE BENEFICIARY’S LETTERHEAD SIGNED BY ONE PURPORTING TO BE AN
OFFICER OR AUTHORIZED REPRESENTATIVE OF THE BENEFICIARY INDICATING NAME AND TITLE OF THE SIGNER
WITH THE FOLLOWING WORDING:

“THE UNDERSIGNED BEING A DULY AUTHORIZED REPRESENTATIVE OR OFFICER OF THE RICHARD T. PEERY
SEPARATE PROPERTY TRUST AND THE JOHN ARRILLAGA SURVIVOR’S TRUST (“LANDLORD”), HEREBY
REPRESENTS AND WARRANTS THAT THE AMOUNT OF THE ACCOMPANYING DRAFT REPRESENTS AND COVERS MONIES DUE
AND OWING TO LANDLORD BY GENITOPE CORPORATION, UNDER THAT CERTAIN “CONSTRUCTION AGREEMENT” DATED
MAY 16, 2005 ENTERED INTO BETWEEN TENANT AND BENEFICIARY (“CONSTRUCTION AGREEMENT”) RELATED TO THAT
CERTAIN LEASE AGREEMENT 0545-GEN101-01 DATED MAY 16, 2005 BETWEEN GENITOPE CORPORATION AND THE
BENEFICIARY FOR THE PROPERTY LOCATED AT 6900 DUMBARTON CIRCLE-BLDG. IV-5, FREMONT, CA. 94555 (THE
“LEASE”) FOR THE PURPOSE OF COMPLETING CONSTRUCTION OF THE “INTERIOR IMPROVEMENTS” (AS DEFINED IN
THE LEASE”) WITHIN THE PREMISES (AS DEFINED IN THE “LEASE”) IN THE EVENT GENITOPE CORPORATION FAILS
TO PAY ANY SUMS WHEN DUE UNDER ANY CONSTRUCTION
CONTRACT FOR THE “INTERIOR IMPROVEMENTS” OR TO COMPLETE SUCH CONSTRUCTION AS AND WHEN REQUIRED
UNDER THE CONSTRUCTION AGREEMENT OR IN THE EVENT ANY LIENS ARE FILED AGAINST THE PROPERTY (AS
DEFINED IN THE LEASE).

2. The original letter of credit and any amendments thereto. 

Special conditions:

 

 

ANY DRAWING CERTIFICATE MAY BE PRESENTED IN PERSON OR BY TELEFACSIMILE AT (415) 477-3310 TO
THE ATTENTION OF MANAGER, INTERNATIONAL TRADE SERVICES PROVIDED THE DRAWING BY TELECOPY IS
CONFIRMED BY TELEPHONE AT (415) 477-3318, 3259 OR 3253. IF DRAWINGS ARE PRESENTED BY TELEFACSIMILE
SUCH TRANSMISSION SHALL INCLUDE A COPY OF THIS LETTER OF CREDIT AND AMENDMENT(S) IF ANY AND
IMMEDIATELY THEREAFTER, THE ORIGINAL DEMAND AND THIS LETTER OF CREDIT AND AMENDMENT(S) IF ANY,
SHALL BE SENT VIA OVERNIGHT MAIL TO COMERICA BANK, 2 EMBARCADERO CENTER, SAN FRANCISCO, CA. 94111.
IF SUCH DEMAND IS LESS THAN THE FACE AMOUNT OF THIS LETTER OF CREDIT, THE ORIGINAL LETTER OF CREDIT
AND AMENDMENT(S) IF ANY WILL BE IMMEDIATELY RETURNED TO THE BENEFICIARY VIA OVERNIGHT MAIL.

Partial
drawings permitted.

All banking charges including courier and transfer fees are for the account of applicant.

we hereby agree with you that all notices, if any, to the beneficiary from comerica bank, the
issuer of this standby letter of credit, shall be sent to the beneficiary by U.S. Certified Mail at
applicant’s expense.

all draft(s) drawn under this standby letter of credit must be marked “drawn under comerica
bank standby letter of credit no. ___.”

the original of this letter of credit must be presented together with the above documents in
order to endorse the amount of each drawing on the reverse side and will be returned to the
beneficiary unless it is fully utilized.

this letter of credit may be transferred successively in its entirety (but not in part) only up to
the then available amount in favor of a nominated transferee that is the successor in interest to
the beneficiary or is the new owner of certain stated property (“transferee”), assuming such
transfer to such transferee is in compliance with all applicable u.s. laws and regulations. at the
time of transfer, the original letter of credit and original amendment(s) if any, must be
surrendered to us together with our transfer form attached hereto, in case of any transfer under
this letter of credit, the draft and any required statement must be executed by the transferee and
where the beneficiary’s name appears within this standby letter of credit, the transferee’s name is
automatically substituted therefore.

this standby letter of credit sets forth in full the terms of our undertaking and such
undertaking shall not be in any way modified, amended, or amplified by reference to any document,
instrument or agreement referred to herein or in which this standby letter of credit is referred to
or to which this standby letter of credit relates, and any such reference shall not be deemed to
incorporate herein by reference any document, instrument or agreement.

 

 

except so far as otherwise expressly stated this standby letter of credit is subject to the
international standby practices (“ISP98”), international chamber fo commerce (1998 version and any
subsequent revisions).

we hereby engage with you that all document(s) drawn under and in compliance with this standby
letter of credit will be duly honored UPON PRESENTATION at our office located at 2 embarcadero
center, suite 300, san francisco, ca. 94111 or by overnight delivery services on or before the
expiration date at 3:00 pm.

verbiage approved: genitope corporation

by:                                         

its:                                         

date:                                         

 

 

COMERICA BANK HAS PREPARED THIS DRAFT UPON THE REQUEST AND BASED ON INFORMATION SUPPLIED TO IT. NO
REPRESENTATION OR COMMITMENT IS MADE BY ISSUING BANK REGARDING THE ACCURACY OR SUITABILITY OF THIS
DRAFT FOR ITS INTENDED PURPOSE OR THE WILLINGNESS OF ISSUING BANK TO ISSUE THIS LETTER OF CREDIT IN
THIS OR ANY OTHER FORM.

DATE:                                         

BENEFICIARY

THE RICHARD T. PEERY SEPARATE PROPERTY TRUST

AND THE JOHN ARRILLAGA SURVIVOR’S TRUST

2560 MISSION COLLEGE BLVD., SUITE 101

SANTA CLARA, CA. 95054

Construction Security Deposit: 6800 Dumbarton Circle, Fremont, CA (Ardenwood IV-6)

We hereby establish our irrevocable standby letter of credit no. xxxxxx-xx, in your favor for
the account of genitope corporation, 525 penobscot drive, redwood city, ca. 94063 in the amount of
usd$23,000,000.00 (twenty-three million u.s. dollars) to expire on may 30, 2009, available by
payment of your draft(s) at sight on us when accompanied by the following documents:

1. A WRITTEN AND DATED STATEMENT ON THE BENEFICIARY’S LETTERHEAD SIGNED BY ONE PURPORTING TO BE AN
OFFICER OR AUTHORIZED REPRESENTATIVE OF THE BENEFICIARY INDICATING NAME AND TITLE OF THE SIGNER
WITH THE FOLLOWING WORDING:

“THE UNDERSIGNED BEING A DULY AUTHORIZED REPRESENTATIVE OR OFFICER OF THE RICHARD T. PEERY
SEPARATE PROPERTY TRUST AND THE JOHN ARRILLAGA SURVIVOR’S TRUST (“LANDLORD”), HEREBY
REPRESENTS AND WARRANTS THAT THE AMOUNT OF THE ACCOMPANYING DRAFT REPRESENTS AND COVERS MONIES DUE
AND OWING TO LANDLORD BY GENITOPE CORPORATION, UNDER THAT CERTAIN “CONSTRUCTION AGREEMENT” DATED
MAY 16, 2005 ENTERED INTO BETWEEN TENANT AND BENEFICIARY (“CONSTRUCTION AGREEMENT”) RELATED TO THAT
CERTAIN LEASE AGREEMENT 0546-GEN101-01 DATED MAY 16, 2005 BETWEEN GENITOPE CORPORATION AND THE
BENEFICIARY FOR THE PROPERTY LOCATED AT 6800 DUMBARTON CIRCLE-BLDG. IV-6 , FREMONT, CA. 94555 (THE
“LEASE”) FOR THE PURPOSE OF COMPLETING CONSTRUCTION OF THE “INTERIOR IMPROVEMENTS” (AS DEFINED IN
THE LEASE”) WITHIN THE PREMISES (AS DEFINED IN THE “LEASE”) IN THE EVENT GENITOPE CORPORATION FAILS
TO PAY ANY

 

 

SUMS WHEN DUE UNDER ANY CONSTRUCTION CONTRACT FOR THE “INTERIOR
IMPROVEMENTS” OR TO COMPLETE SUCH CONSTRUCTION AS AND WHEN REQUIRED UNDER THE CONSTRUCTION
AGREEMENT OR IN THE EVENT ANY LIENS ARE FILED AGAINST THE PROPERTY (AS DEFINED IN THE LEASE).

2. The original letter of credit and any amendments thereto. 

Special conditions:

ANY DRAWING CERTIFICATE MAY BE PRESENTED IN PERSON OR BY TELEFACSIMILE AT (415) 477-3310 TO THE
ATTENTION OF MANAGER, INTERNATIONAL TRADE SERVICES PROVIDED THE DRAWING BY TELECOPY IS CONFIRMED BY
TELEPHONE AT (415) 477-3318, 3259 OR 3253. IF DRAWINGS ARE PRESENTED BY TELEFACSIMILE SUCH
TRANSMISSION SHALL INCLUDE A COPY OF THIS LETTER OF CREDIT AND AMENDMENT(S) IF ANY AND IMMEDIATELY
THEREAFTER, THE ORIGINAL DEMAND AND THIS LETTER OF CREDIT AND AMENDMENT(S) IF ANY, SHALL BE SENT
VIA OVERNIGHT MAIL TO COMERICA BANK, 2 EMBARCADERO CENTER, SAN FRANCISCO, CA. 94111. IF SUCH
DEMAND IS LESS THAN THE FACE AMOUNT OF THIS LETTER OF CREDIT, THE ORIGINAL LETTER OF CREDIT AND
AMENDMENT(S) IF ANY WILL BE IMMEDIATELY RETURNED TO THE BENEFICIARY VIA OVERNIGHT MAIL.

Partial
drawings permitted.

All banking charges including courier and transfer fees are for the account of applicant.

we hereby agree with you that all notices, if any, to the beneficiary from comerica bank, the
issuer of this standby letter of credit, shall be sent to the beneficiary by U.S. Certified Mail at
applicant’s expense.

all draft(s) drawn under this standby letter of credit must be marked “drawn under comerica
bank standby letter of credit no. ___.”

the original of this letter of credit must be presented together with the above documents in
order to endorse the amount of each drawing on the reverse side and will be returned to the
beneficiary unless it is fully utilized.

this letter of credit may be transferred successively in its entirety (but not in part) only up to
the then AVAILABLE AMOUNT in favor of a nominated transferee that is the successor in interest to
the beneficiary or is the new owner of certain stated property (“transferee”), assuming such
transfer to such transferee is in compliance with all applicable u.s. laws and regulations. at the
time of transfer, the original letter of credit and original

 

 

amendment(s) if any, must be
surrendered to us together with our transfer form attached hereto, in case of any transfer under
this letter of credit, the draft and any required statement must be executed by the transferee and
where the beneficiary’s name appears within this standby letter of credit, the transferee’s name is
automatically substituted therefore.

this standby letter of credit sets forth in full the terms of our undertaking and such
undertaking shall not be in any way modified, amended, or amplified by reference to any document,
instrument or agreement referred to herein or in which this standby letter of credit is referred to
or to which this standby letter of credit relates, and any such reference shall not be deemed to
incorporate herein by reference any document, instrument or agreement.

except so far as otherwise expressly stated this standby letter of credit is subject to the
international standby practices (“ISP98”), international chamber fo commerce (1998 version and any
subsequent revisions).

we hereby engage with you that all document(s) drawn under and in compliance with this standby
letter of credit will be duly honored UPON PRESENTATION at our office located at 2 embarcadero
center, suite 300, san francisco, ca. 94111 or by overnight delivery services on or before the
expiration date at 3:00 pm.

verbiage approved: genitope corporation

by:                                         

its:                                         

date:                                         

 

 

COMERICA BANK HAS PREPARED THIS DRAFT UPON THE REQUEST AND BASED ON INFORMATION SUPPLIED TO IT. NO
REPRESENTATION OR COMMITMENT IS MADE BY ISSUING BANK REGARDING THE ACCURACY OR SUITABILITY OF THIS
DRAFT FOR ITS INTENDED PURPOSE OR THE WILLINGNESS OF ISSUING BANK TO ISSUE THIS LETTER OF CREDIT IN
THIS OR ANY OTHER FORM.

DATE:                                         

BENEFICIARY

THE RICHARD T. PEERY SEPARATE PROPERTY TRUST

AND THE JOHN ARRILLAGA SURVIVOR’S TRUST

2560 MISSION COLLEGE BLVD., SUITE 101

SANTA CLARA, CA. 95054

Security Deposit: 6900 Dumbarton Circle, Fremont, CA (Ardenwood IV-5)

We hereby establish our irrevocable standby letter of credit no. xxxxxx-xx, in your favor for
the account of genitope corporation, 525 penobscot drive, redwood city, ca. 94063 in the amount of
usd$500,000.00 (five hundred thousand u.s. dollars) to expire on january 29, 2021, available by
payment of your draft(s) at sight on us when accompanied by the following documents:

1. A WRITTEN AND DATED STATEMENT ON THE BENEFICIARY’S LETTERHEAD SIGNED BY ONE PURPORTING TO BE AN
OFFICER OR AUTHORIZED REPRESENTATIVE OF THE BENEFICIARY INDICATING NAME AND TITLE OF THE SIGNER
WITH THE FOLLOWING WORDING:

“THE UNDERSIGNED BEING A DULY AUTHORIZED REPRESENTATIVE OR OFFICER OF THE RICHARD T. PEERY
SEPARATE PROPERTY TRUST AND THE JOHN ARRILLAGA SURVIVOR’S TRUST (“LANDLORD”), HEREBY
REPRESENTS AND WARRANTS THAT THE AMOUNT OF THE ACCOMPANYING DRAFT REPRESENTS AND COVERS MONIES DUE
AND OWING TO LANDLORD BY GENITOPE CORPORATION (TENANT), PURSUANT TO A “DEFAULT” AS DEFINED UNDER
THAT LEASE AGREEMENT 0545-GEN101-01 DATED MAY 16, 2005 LOCATED AT 6900 DUMBARTON CIRCLE, FREMONT,
CA. 94555 (THE “LEASE”) BY AND BETWEEN LANDLORD AND TENANT, AND ANY CURE PERIODS OR GRACE PERIODS
FOR SUCH DEFAULT HAVE LAPSED WITHOUT REMEDY FOLLOWING RECEIPT BY TENANT OF THE NOTICE OF SUCH
DEFAULT. FURTHERMORE, LANDLORD HEREBY REPRESENTS AND WARRANTS AND DELIVERS EVIDENCE THAT LANDLORD
HAS PROVIDED TO TENANT THE WRITTEN NOTICE OF SUCH DEFAULT WHICH WAS RECEIVED BY TENANT UNDER THE
APPLICABLE PROVISIONS OF THE LEASE.”

2. The original letter of credit and any amendments thereto. 

Special conditions:

ANY DRAWING CERTIFICATE MAY BE PRESENTED IN PERSON OR BY TELEFACSIMILE AT (415) 477-3310 TO
THE ATTENTION OF MANAGER, INTERNATIONAL TRADE SERVICES PROVIDED THE DRAWING BY TELECOPY IS
CONFIRMED BY TELEPHONE AT (415) 477-3318, 3259 OR 3253. IF DRAWINGS ARE PRESENTED BY TELEFACSIMILE
SUCH TRANSMISSION

 

 

SHALL INCLUDE A COPY OF THIS LETTER OF CREDIT AND AMENDMENT(S) IF ANY AND
IMMEDIATELY THEREAFTER, THE ORIGINAL DEMAND AND THIS LETTER OF CREDIT AND AMENDMENT(S) IF ANY,
SHALL BE SENT VIA OVERNIGHT MAIL TO COMERICA BANK, 2 EMBARCADERO CENTER, SAN FRANCISCO, CA. 94111.
IF SUCH DEMAND IS LESS THAN THE FACE AMOUNT OF THIS LETTER OF CREDIT, THE ORIGINAL LETTER OF CREDIT
AND AMENDMENT(S) IF ANY WILL BE IMMEDIATELY RETURNED TO THE BENEFICIARY VIA OVERNIGHT MAIL.

Partial
drawings permitted.

All banking charges including courier and transfer fees are for the account of applicant.

we hereby agree with you that all notices, if any, to the beneficiary from comerica bank, the
issuer of this standby letter of credit, shall be sent to the beneficiary by U.S. Certified Mail at
applicant’s expense.

all draft(s) drawn under this standby letter of credit must be marked “drawn under comerica
bank standby letter of credit no. ___.”

the original of this letter of credit must be presented together with the above documents in
order to endorse the amount of each drawing on the reverse side and will be returned to the
beneficiary unless it is fully utilized.

this letter of credit may be transferred successively in its entirety (but not in part) only up to
the then AVAILABLE AMOUNT in favor of a nominated transferee that is THE SUCCESSOR in interest to
the beneficiary or is the new owner of certain stated property (“transferee”), assuming
such transfer to such transferee is in compliance with all applicable u.s. laws and regulations.
at the time of transfer, the original letter of credit and original amendment(s) if any, must be
surrendered to us together with our transfer form attached hereto, in case of any transfer under
this letter of credit, the draft and any required statement must be executed by the transferee and
where the beneficiary’s name appears within this standby letter of credit, the transferee’s name is
automatically substituted therefore.

this standby letter of credit sets forth in full the terms of our undertaking and such
undertaking shall not be in any way modified, amended, or amplified by reference to any document,
instrument or agreement referred to herein or in which this standby letter of credit is referred to
or to which this standby letter of credit relates, and any such reference shall not be deemed to
incorporate herein by reference any document, instrument or agreement.

except so far as otherwise expressly stated this standby letter of credit is subject to the
international standby practices (“ISP98”), international chamber fo commerce (1998 version and any
subsequent revisions).

we hereby engage with you that all document(s) drawn under and in

 

 

compliance with this standby
letter of credit will be duly honored upon presentation at our office located at 2 embarcadero
center, suite 300, san francisco, ca. 94111 or by overnight delivery services on or before the
expiration date at 3:00 pm.

verbiage approved: genitope corporation

by:                                         

its:                                         

date:                                     

 

 

COMERICA BANK HAS PREPARED THIS DRAFT UPON THE REQUEST AND BASED ON INFORMATION SUPPLIED TO IT. NO
REPRESENTATION OR COMMITMENT IS MADE BY ISSUING BANK REGARDING THE ACCURACY OR SUITABILITY OF THIS
DRAFT FOR ITS INTENDED PURPOSE OR THE WILLINGNESS OF ISSUING BANK TO ISSUE THIS LETTER OF CREDIT IN
THIS OR ANY OTHER FORM.

DATE:                                         

BENEFICIARY

THE RICHARD T. PEERY SEPARATE PROPERTY TRUST

AND THE JOHN ARRILLAGA SURVIVOR’S TRUST

2560 MISSION COLLEGE BLVD., SUITE 101

SANTA CLARA, CA. 95054

Security Deposit: 6800 Dumbarton Circle, Fremont, CA (Ardenwood IV-6)

We hereby establish our irrevocable standby letter of credit no. xxxxxx-xx, in your favor for
the account of genitope corporation, 525 penobscot drive, redwood city, ca. 94063 in the amount of
usd $500,000.00 (five hundred thousand u.s. dollars) to expire on january 29, 2021, available by
payment of your draft(s) at sight on us when accompanied by the following documents:

1. A WRITTEN AND DATED STATEMENT ON THE BENEFICIARY’S LETTERHEAD SIGNED BY ONE PURPORTING TO BE AN
OFFICER OR AUTHORIZED REPRESENTATIVE OF THE BENEFICIARY INDICATING NAME AND TITLE OF THE SIGNER
WITH THE FOLLOWING WORDING:

“THE UNDERSIGNED BEING A DULY AUTHORIZED REPRESENTATIVE OR OFFICER OF THE RICHARD T. PEERY
SEPARATE PROPERTY TRUST AND THE JOHN ARRILLAGA SURVIVOR’S TRUST (“LANDLORD”), HEREBY
REPRESENTS AND WARRANTS THAT THE AMOUNT OF THE ACCOMPANYING DRAFT REPRESENTS AND COVERS MONIES DUE
AND OWING TO LANDLORD BY GENITOPE CORPORATION (TENANT), PURSUANT TO A “DEFAULT” AS DEFINED UNDER
THAT LEASE AGREEMENT 0546-GEN101-01 DATED MAY 16, 2005 LOCATED AT 6800 DUMBARTON CIRCLE, FREMONT,
CA. 94555 (THE “LEASE”) BY AND BETWEEN LANDLORD AND TENANT, AND ANY CURE PERIODS OR GRACE PERIODS
FOR SUCH DEFAULT HAVE LAPSED WITHOUT REMEDY FOLLOWING RECEIPT BY TENANT OF THE NOTICE OF SUCH
DEFAULT. FURTHERMORE, LANDLORD HEREBY REPRESENTS AND WARRANTS AND DELIVERS EVIDENCE THAT LANDLORD
HAS PROVIDED TO TENANT THE WRITTEN NOTICE OF SUCH DEFAULT WHICH WAS RECEIVED BY TENANT UNDER THE
APPLICABLE PROVISIONS OF THE LEASE.”

2. The original letter of credit and any amendments thereto. 

Special conditions:

ANY DRAWING CERTIFICATE MAY BE PRESENTED IN PERSON OR BY TELEFACSIMILE AT (415) 477-3310 TO
THE ATTENTION OF MANAGER, INTERNATIONAL TRADE SERVICES PROVIDED THE DRAWING BY TELECOPY IS
CONFIRMED BY TELEPHONE AT (415) 477-3318, 3259 OR 3253. IF DRAWINGS ARE PRESENTED BY TELEFACSIMILE
SUCH TRANSMISSION

 

 

SHALL INCLUDE A COPY OF THIS LETTER OF CREDIT AND AMENDMENT(S) IF ANY AND
IMMEDIATELY THEREAFTER, THE ORIGINAL DEMAND AND THIS LETTER OF CREDIT AND AMENDMENT(S) IF ANY,
SHALL BE SENT VIA OVERNIGHT MAIL
TO COMERICA BANK, 2 EMBARCADERO CENTER, SAN FRANCISCO, CA. 94111. IF SUCH DEMAND IS LESS THAN THE
FACE AMOUNT OF THIS LETTER OF CREDIT, THE ORIGINAL LETTER OF CREDIT AND AMENDMENT(S) IF ANY WILL BE
IMMEDIATELY RETURNED TO THE BENEFICIARY VIA OVERNIGHT MAIL.

Partial
drawings permitted.

All banking charges including courier and transfer fees are for the account of applicant.

we hereby agree with you that all notices, if any, to the beneficiary from comerica bank, the
issuer of this standby letter of credit, shall be sent to the beneficiary by U.S. Certified Mail
at applicant’s expense.

all draft(s) drawn under this standby letter of credit must be marked “drawn under comerica
bank standby letter of credit no. ___.”

the original of this letter of credit must be presented together with the above documents in
order to endorse the amount of each drawing on the reverse side and will be returned to the
beneficiary unless it is fully utilized.

this letter of credit may be transferred successively in its entirety (but not in part) only up to
the then AVAILABLE AMOUNT in favor of a nominated transferee that is the successor in interest to
the beneficiary or is the new owner of certain stated property (“transferee”), assuming such
transfer to such transferee is in compliance with all applicable u.s. laws and regulations. at the
time of transfer, the original letter of credit and original amendment(s) if any, must be
surrendered to us together with our transfer form attached hereto, in case of any transfer under
this letter of credit, the draft and any required statement must be executed by the transferee and
where the beneficiary’s name appears within this standby letter of credit, the transferee’s name is
automatically substituted therefore.

this standby letter of credit sets forth in full the terms of our undertaking and such
undertaking shall not be in any way modified, amended, or amplified by reference to any document,
instrument or agreement referred to herein or in which this standby letter of credit is referred to
or to which this standby letter of credit relates, and any such reference shall not be deemed to
incorporate herein by reference any document, instrument or agreement.

except so far as otherwise expressly stated this standby letter of credit is subject to the
international standby practices (“ISP98”), international chamber fo commerce (1998 version and any
subsequent revisions).

 

 

we hereby engage with you that all document(s) drawn under and in compliance with this standby
letter of credit will be duly honored UPON PRESENTATION at our offices located at 2 embarcadero
center, suite 300, san francisco, ca. 94111 or by overnight delivery services on or before the
expiration date at 3:00 pm.

verbiage approved: genitope corporation

by:                                         

its:                                         

date:exv10w2

 

Exhibit 10.2

SECURITY AGREEMENT — ACCOUNT PLEDGE

     THIS SECURITY AGREEMENT ACCOUNT PLEDGE (this “Agreement”), dated as of December 15,
2005, is entered into by and between GENITOPE CORPORATION, a Delaware corporation (the “Pledgor”),
and COMERICA BANK, a Michigan banking corporation (the “Secured Party”)., in light of the
following:

R E C I T A L S:

     WHEREAS, Secured Party and Pledgor have entered into that certain Letter of Credit and
Reimbursement Agreement (“LCRA”), dated as of the date hereof (as the same may be from time to time
hereafter amended or supplemented and together with all other agreements, instruments and documents
executed by and between Secured Party and Pledgor in connection therewith, the “Loan
Documents”), pursuant to which Secured Party extended certain financial accommodations to
Pledgor;

     WHEREAS, Pledgor has agreed to secure its obligations under the Loan Documents pursuant to the
terms and provisions of this Agreement.

     NOW, THEREFORE, in consideration of the recitals and for other good and valuable
consideration, receipt of which is hereby acknowledged, Pledgor hereby agrees with Secured Party as
follows:

     SECTION 1. Pledge.

     (a) Unless otherwise defined herein, each term used in this Agreement which is defined in the
California Uniform Commercial Code, as amended from time to time, (the “Code”) shall have
the meaning set forth herein. Capitalized terms used herein which are defined in the LCRA and are
not defined to the contrary herein have the meanings given them in the LCRA.

     (b) Pledgor hereby pledges and grants to Secured Party a first priority lien on and security
interest in each and all of the following items of collateral (hereinafter collectively referred to
as the “Collateral”):

     (i) All of Pledgor’s right, title and interest, including the right to receive all payments of
principal and interest, in and to the Account specifically described in the Supplemental Letter
between Bank and Borrower of even date herewith, and all cash and investments (including without
limitation, Approved Investments, as defined in the LCRA) from time to time deposited or credited
to the Account (the “Account”);

     (ii) All of Pledgor’s right, title and interest, including the right to receive all payments
of principal and interest, in and to those certain certificates of deposit, as described in the
Supplemental Letter between Bank and Borrower of even date herewith, together with any and all
additions, renewals, replacements, rollovers, reinvestments or substitutions thereof or therefor
(the “Certificates”); and

- 1 -

 

     (iii) All proceeds of the Account and Certificates, including all rights, benefits, principal
payments, interest payments, dividends, distributions, premiums, profits, insurance proceeds,
documents, securities, accounts, instruments, chattel paper, notes, general intangibles, inventory,
goods, equipment, deposit accounts, money and whatever other tangible and intangible property is
received by the Pledgor upon the liquidation, sale or other disposition of the Account and/or
Certificates, or the proceeds thereof.

     (c) This Agreements secures, and the Collateral is collateral security for, the prompt and
complete payment of any and all debts, liabilities, obligations (including the obligations of
Pledgor under the Loan Documents), covenants and duties owing by Pledgor to Secured Party of any
kind and description, whether direct or indirect, absolute or contingent, due or to become due, now
existing or hereafter arising under this Agreement or the Loan Documents, and further including all
costs, fees, and expenses which Pledgor is required to pay or reimburse by this Agreement or the
Loan Documents by law or otherwise (collectively, the “Obligations”).

     (d) Pledgor further agrees to execute and deliver to Secured Party, or to such other party as
Secured Party shall direct, in form and substance as Secured Party shall reasonably request, all
security agreements, control agreements, assignments, financing statements, instructions,
instruments, notices, and other documents or agreements and to take all further action, at the
expense of Pledgor, from time to time reasonably requested by Secured Party in order to maintain a
first priority perfected security interest in the Collateral in favor of Secured Party or to enable
Secured Party to exercise and enforce its rights and remedies hereunder with respect to the
Collateral, or to effect a transfer of the Collateral or any part thereof. Pledgor shall take all
steps necessary to ensure that all certificates (including certificated securities) or instruments
representing or evidencing the Collateral, if any, shall be delivered to and held by Secured Party
pursuant hereto and shall be in suitable form for transfer or assignment in blank, all in form and
substance satisfactory to Secured Party.

     SECTION 2. Payments on the Certificates.

     (a) Prior to the occurrence of an Event of Default hereunder, Pledgor shall be entitled to
receive payments of interest, dividends, or other income made on the Certificates.

     (b) If, after the occurrence and continuance of an Event of Default hereunder, Pledgor shall
become entitled to receive any principal, interest or premium payment in respect of the
Certificates, then Pledgor shall be deemed to have accepted the same as Secured Party’s agent,
shall hold such payments in trust on behalf of Secured Party, and shall immediately deliver all
such payments to Secured Party. All sums of money which are received by Secured Party in respect
of the Certificates pursuant to this provision shall be deemed collections under Section 9608 of
the Code and shall be credited against the Obligations.

     SECTION 3. Release of Collateral.

     (a) At such time as all of the Obligations (other than inchoate obligations to indemnify
Secured Party) under the Loan Documents have been fully and finally satisfied with respect to
Letter of Credit, and Pledgor is no longer obligated to Secured Party under the Loan Documents,
this Agreement (and the liens granted hereunder) shall automatically terminate.

- 2 -

 

     SECTION 4. Representations, Warranties, and Covenants of Pledgor.

     Pledgor represents, warrants, and covenants to Secured Party that:

     (a) The Collateral is owned by Pledgor and is not subject to any restrictions on transfer or
pledge;

     (b) Pledgor has full power, authority, and legal right to pledge all of its right, title, and
interest in and to the Collateral pursuant to this Agreement;

     (c) This Agreement has been duly authorized, executed, and delivered by Pledgor and
constitutes a legal, valid, and binding obligation of Pledgor enforceable in accordance with its
terms except as such enforceability may be limited by bankruptcy, insolvency, reorganization,
moratorium or similar laws affecting creditors’ rights generally and by general principles of
equity (regardless of whether such enforceability is considered in a proceeding in equity or at
law);

     (d) No consent of any other party (including, without limitation, other creditors of Pledgor)
and no consent, license, permit, approval, or authorization of, exemption by, notice or report to,
or registration, filing, or declaration with, any governmental authority, domestic or foreign, is
required to be obtained by Pledgor in connection with the execution, delivery, or performance of
this Agreement;

     (e) The execution, delivery, and performance by Pledgor of this Agreement requires no action
by or in respect of, or filing with, any governmental body, agency, or official, and does not
violate or contravene, or constitute a default under, any law or regulation applicable to Pledgor
or of any material agreement, judgment, injunction, order, decree, or other instrument binding upon
Pledgor, or result in the creation or imposition of any lien on any assets of Pledgor except as
contemplated by this Agreement;

     (f) The pledge and assignment of the Collateral pursuant to this Agreement creates a valid
first priority Lien on and a first priority perfected security interest in the Collateral, not
subject to any prior lien or encumbrance in favor of any third party. Pledgor covenants that the
Collateral is now and at all times shall remain free of all liens and encumbrances, other than
Permitted Encumbrances. Pledgor covenants and agrees that it will defend Secured Party’s right,
title and security interest in and to the Collateral against the claims and demands of all persons;

     (g) Pledgor hereby covenants that so long as the Letter of Credit A is outstanding or any of
the Obligations (other than inchoate obligations to indemnify Secured Party) shall remain
outstanding, Secured Party shall have control over the Collateral within the meaning of Section
9104 of the Code, and Pledgor shall have no right to withdraw any of the Collateral, and Pledgor
shall not liquidate, cause or permit to be liquidated, or effect, or cause or permit to be
effected, any other disposition of the Collateral, in whole or in part other than dispositions of
the Collateral for the purpose of obtaining replacement Approved Investments in accordance with
Section 3 of the Account Control Agreement. Pledgor further covenants that it will not borrow
against, encumber, or otherwise deal with the Collateral so as to reduce its interest therein to
less than the amount required under clause (g) of this Section, except for Permitted Encumbrances;

- 3 -

 

     (h) Pledgor shall not, at any time, permit the amount of its Obligations with respect to
Letter of Credit A (including the undrawn face amount of any Letter of Credit A) to exceed 90% of
the market value of the Collateral in the Account.

     (i) Pledgor hereby grants to Secured Party an irrevocable power of attorney, with full power
of substitution coupled with an interest, to, so long as any of the Obligations (other than
inchoate obligations to indemnify Secured Party) hereunder and under the Loan Documents shall
remain outstanding, execute and endorse, as applicable, on behalf of Pledgor, such financing
statements, continuation financing statements, security agreements, reports, notices, and all other
documents, instruments and agreements and perform any other acts (including pressing any claim) in
order to: (i) perfect and maintain perfected security interest in the Collateral; (ii) fully
consummate all of the transactions contemplated under this Agreement and the Loan Documents; and
(iii) effect and exercise the rights and remedies of Secured Party with respect to the Collateral
as set forth in this Agreement.

     SECTION 5. No Disposition.

     Except in accordance with the terms of the Loan Documents, without the prior written consent
of Secured Party, Pledgor agrees that it will not sell, assign, transfer, exchange, or otherwise
dispose of, or grant any option with respect to, the Collateral, nor will it create, incur, or
permit to exist any assessment, pledge, lien, mortgage, hypothecation, security interest, charge,
option, or any other encumbrance with respect to any of the Collateral, any interest therein, or
any proceeds thereof other than dispositions of the Collateral for the purpose of obtaining
replacement Approved Investments in accordance with Section 3 of the Account Control Agreement.

     SECTION 6. Obligations of Pledgor Unconditional.

     Pledgor’s duty to perform and observe the agreements and covenants on its part contained
herein shall be absolute and unconditional.

     SECTION 7. Events of Default. The occurrence and continuance of any Event of Default
under the Loan Documents shall be an “Event of Default” hereunder.

     SECTION 8. Remedies Upon Default.

     (a) If an Event of Default should occur and continue, Secured Party shall have all of the
rights and remedies of a secured party under the Code, under this Agreement, and under applicable
law, and available in equity. In addition, Secured Party shall have the right, to the full extent
permitted by law, and Pledgor shall take such action necessary or appropriate to give effect to
such right and to give consents, ratifications, and waivers thereto, to take any other action with
respect to the Collateral as if Secured Party were the absolute and sole owner thereof including,
without limitation, the right to liquidate and/or convert to cash all or any part of the Collateral
(including Certificates of Deposit and/or Approved Investments) and to, at Bank’s option, apply
cash proceeds thereof to Obligations then owing and/or to hold the proceeds thereof as continuing
security for Obligations whether such Obligations are then due.

- 4 -

 

     (b) If an Event of Default should occur and continue, Secured Party shall have the right to
exercise any and all rights and remedies provided by this Agreement (including application of any
cash Collateral, to the repayment of Pledgor’s obligations owing to Secured Party hereunder and
under the Loan Documents), to sell the Collateral, or any part thereof, at public or private sale
or on any securities exchange, for cash, upon credit, or for future delivery, and at such price or
prices as Secured Party may deem commercially reasonable. Secured Party may purchase any or all of
the Collateral so sold at any public sale (or, with respect to any portion of the Collateral which
is of a type customarily sold in a recognized market or is of a type which is the subject of widely
distributed standard price quotations, at any private sale) and thereafter hold the same free from
any right or claim of whatsoever kind. Secured Party is authorized, at any such sale, if it deems
it advisable to do so, to restrict the prospective bidders or purchasers of any of the Collateral
to persons who will represent and agree that they are purchasing for their own account for
investment, and not with a view to the distribution or sale of any of the Collateral. To the
extent that any portion of the Collateral is not of a type customarily sold on a recognized market,
Secured Party shall give Pledgor at least ten (10) days written notice of its intention to make any
such public or private sale of that portion of the Collateral.

     (c) Pledgor hereby agrees that any disposition of Collateral by way of a private placement or
other method which in the reasonable opinion of counsel for Secured Party is required or advisable
under federal and state securities laws shall be deemed to be commercially reasonable. Pledgor
also agrees that, except for duties set forth in the Code, Secured Party has no duty to sell or
otherwise dispose of the Collateral, either before or after an Event of Default, whether upon the
request of Pledgor or otherwise.

     (d) Pledgor agrees to pay to Secured Party, promptly on demand following any Event of Default,
such reasonable amount of costs, fees and expenses (all of which shall constitute obligations)
incurred by Secured Party in connection with the exercise of its rights under this Section 8,
including reasonable attorneys’ fees, disbursements, and legal expenses, whether or not suit is
brought.

     (e) Secured Party’s remedies under this Agreement are cumulative and in addition to all other
remedies which it may possess, at law, in equity, under any other agreement, or otherwise.

     SECTION 9. No Waiver.

     No failure on the part of Secured Party to exercise, and no delay in exercising, any right,
power, or remedy hereunder shall operate as a waiver thereof, nor shall any single or partial
exercise of any such right, power, or remedy by Secured Party preclude any other or further
exercise thereof or the exercise of any other right, power, or remedy.

     SECTION 10. Miscellaneous.

     (a) All notices, requests, and other communications to Secured Party or to Pledgor shall be
given and shall be effective in accordance with the terms of the LCRA.

     (b) Unless the context of this Agreement clearly requires otherwise, references to the plural
include the singular and to the singular include the plural, references to any gender include

- 5 -

 

any other gender, the part includes the whole, the term “including” is not limiting, and the
term “or” has, except where otherwise indicated, the inclusive meaning represented by the phrase
“and/or.” The words “hereof,” “herein,” “hereby,” “hereunder,” and similar terms in this Agreement
refer to this Agreement as a whole and not to any particular provision of this Agreement. Article,
section, subsection, clause, exhibit and schedule references are to this Agreement, unless
otherwise specified. Initially capitalized terms contained in this Agreement and not separately
defined herein shall have the meanings ascribed thereto in the LCRA.

     (c) Any provision of this Agreement which is prohibited or unenforceable in any jurisdiction
shall, as to such jurisdiction, be ineffective to the extent of such prohibition or
unenforceability without invalidating the remaining provisions hereof or affecting the validity or
enforceability of such provision in any other jurisdiction.

     (d) This Agreement sets forth the entire understanding between Pledgor and Secured Party
regarding the subject matter of this Agreement, and all prior agreements or understandings, if any,
regarding the subject matter hereof are merged herein. This Agreement may not be amended, changed,
modified, altered, or terminated except by means of a writing signed by the parties hereto.

     (e) The subject headings and the sections and subsections of this Agreement are included for
purposes of convenience only and shall not affect the construction or interpretation of any of its
provisions.

     (f) This Agreement may be signed in counterparts, each of which shall be an original, with the
same effect as if the signatures thereto and hereto were upon the same instrument.

     SECTION 11. CHOICE OF LAW AND VENUE; JURY TRIAL WAIVER.

     (a) THE VALIDITY OF THIS AGREEMENT, THE CONSTRUCTION, INTERPRETATION, AND ENFORCEMENT HEREOF,
AND THE RIGHTS OF THE PARTIES HERETO WITH RESPECT TO ALL MATTERS ARISING HEREUNDER OR RELATED
HERETO SHALL BE DETERMINED UNDER, GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH THE INTERNAL LAWS
OF THE STATE OF CALIFORNIA, WITHOUT REGARD FOR PRINCIPLES OF CONFLICTS OF LAWS.

     (b) THE PARTIES AGREE THAT ALL ACTIONS OR PROCEEDINGS ARISING IN CONNECTION WITH THIS
AGREEMENT SHALL BE TRIED AND LITIGATED ONLY IN THE STATE AND FEDERAL COURTS LOCATED IN THE COUNTY
OF LOS ANGELES, STATE OF CALIFORNIA, PROVIDED, HOWEVER, THAT ANY SUIT SEEKING
ENFORCEMENT AGAINST ANY COLLATERAL OR OTHER PROPERTY MAY BE BROUGHT, AT SECURED PARTY’S OPTION, IN
THE COURTS OF ANY JURISDICTION WHERE SECURED PARTY ELECTS TO BRING SUCH ACTION OR WHERE SUCH
COLLATERAL OR OTHER PROPERTY MAY BE FOUND. THE PLEDGOR AND THE SECURED PARTY WAIVE, TO THE EXTENT
PERMITTED UNDER APPLICABLE LAW, ANY RIGHT EACH MAY HAVE TO ASSERT THE DOCTRINE OF FORUM NON
CONVENIENS OR TO OBJECT TO

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VENUE TO THE EXTENT ANY PROCEEDING IS BROUGHT IN ACCORDANCE WITH THIS SECTION.

     (c) THE PLEDGOR AND THE SECURED PARTY HEREBY WAIVE THEIR RESPECTIVE RIGHTS TO A JURY TRIAL OF
ANY CLAIM OR CAUSE OF ACTION BASED UPON OR ARISING OUT OF THIS AGREEMENT OR ANY OF THE TRANSACTIONS
CONTEMPLATED HEREIN, INCLUDING CONTRACT CLAIMS, TORT CLAIMS, BREACH OF DUTY CLAIMS, AND ALL OTHER
COMMON LAW OR STATUTORY CLAIMS. THE PLEDGOR AND SECURED PARTY REPRESENT THAT EACH HAS REVIEWED
THIS WAIVER AND EACH KNOWINGLY AND VOLUNTARILY WAIVES ITS JURY TRIAL RIGHTS FOLLOWING CONSULTATION
WITH LEGAL COUNSEL. IN THE EVENT OF LITIGATION, A COPY OF THIS AGREEMENT MAY BE FILED AS A WRITTEN
CONSENT TO A TRIAL BY THE COURT.

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     IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be duly executed as of
the date first above written.

“PLEDGOR”

	 	 	 	 	 
	 	GENITOPE CORPORATION

 	 
	 	By:  	
/s/ John Vuko	 
	 	Name:  	 	 John Vuko	 
	 	Title:  	 	 CFO	 
	 

“SECURED PARTY”

	 	 	 	 	 
	 	COMERICA BANK, a Michigan banking corporation

 	 
	 	By:  	
/s/ Robert Hurley	 
	 	Name:  	 	 Robert Hurley	 
	 	Title:  	 	 Vice
President	 
	 

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Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00095-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00095-of-00352.parquet"}]]