Document:

First Amendment to Lease

 Exhibit 10.11 

FIRST AMENDMENT 

to 
 LEASE BETWEEN

 EMERY STATION JOINT VENTURE, LLC (LANDLORD) 

And 

ZOGENIX, INC. (TENANT) 

EMERYSTATION I PROJECT 

Emeryville, California 
 That
certain Lease dated October 31, 2006 by and between Emery Station Joint Venture, LLC, as Landlord, and Zogenix, Inc., as Tenant, is hereby amended by this First Amendment dated July 10, 2007 as follows: 

I. 
 Tenant has requested, and
Landlord has agreed to (subject to its ability to relocate the existing tenant thereof under commercially reasonable terms) an expansion of the proposed Premises to include the 3,253 rentable square foot Suite 465 (the “Expansion
Space”), which is immediately north of Tenant’s existing 4,163 rentable square foot Premises (the “Existing Premises”). Both Landlord and Tenant shall have the right to cancel this First Lease Amendment, with no liability of
either to the other, if said existing tenant shall not have vacated the Expansion Space within ninety (90) days of the date hereof. 
 II.

 Effective upon delivery of Suite 465 in its as-is condition (once the existing tenant has moved out including removal of
its furniture unless said furniture has been available to be purchased and Tenant has elected to do so), which date shall be referred to as the “Expansion Space Commencement Date”, the base Lease will be modified as follows: 

a) 

Section 1.1(5) LEASE TERM shall become four (4) years following the first day of calendar month following the Expansion Space
Commencement Date. 
 b) 

Section 1.1(8) MONTHLY BASE RENT shall be modified as follows: The Expansion Space shall bear Monthly Base Rent of $10,000.00 during
the first 12 months following the Expansion Space Commencement Date (the equivalent of $3.074 per rentable square foot per month). On the first Anniversary of the Expansion Space Commencement Date and annually thereafter this Monthly Base Rent
shall increase by three percent (3%). Per the terms of the Lease, Tenant’s Existing Premises bears Monthly Base Rent of $10,823.80 through November 30, 2007, at which time it becomes $11,148.51 through November 30, 2008. For the
period from December 1, 2008 until the end of the newly-extended Lease Term pursuant to II(a) above, the Existing Premises will bear Monthly Base Rent at the same rate per square foot as the Expansion Premises is scheduled to bear. 

c) 

Section 1.1(9) RENTABLE AREA OF THE PREMISES shall become 7,416 square feet and Tenant’s pro-rata share shall be adjusted
accordingly. 
 d) 

Section 1.I (1 0) BASE YEAR shall be modified to indicate that the Base Year for both the Existing Premises and the Expansion
Premises shall be 2007. 

 e) 

Section 1.1(13) PARKING shall, be modified such that Tenant shall be entitled to as many as ten (10) more non-premium spaces on
an as needed basis, making the total non-premium spaces to which they are entitled nineteen (19). 
 f) 

Section I .1(14) SECURITY DEPOSIT shall be modified as follows: Within five (5) business days of the Expansion Space
Commencement Date, tenant shall remit $17,423.06 in good and collected funds to Landlord to increase the Security Deposit under the Lease to a new total of $39,720.08. 
  

 
 III. 

Upon the Expansion Space Commencement Date, Landlord shall make available to Tenant a Tenant Improvement Allowance totaling $95,628.75,
which funds Tenant can use to reimburse itself for valid, documentable third-party costs associated with improvements that Tenant has already made to its Existing Space and/or for improvements Tenant will make after the date hereof to either the
Expansion Space and/or its Existing Premises. 
 IV. 

Article 20 regarding relocation shall continue to prohibit this right by Landlord during the last six months of the Lease Term.

 V. 
 A new section
shall be added to Tenant’s Lease as follows: 
 RIGHT OF SECOND EXPANSION 

During the first six (6) months following the date of this First Amendment, Tenant may provide a written notice to Landlord that it
intends to lease the 1,602 rentable square foot Suite 453 (the “Second Expansion Space”), which suite is currently being used as a conference room and marketing office by an affiliate of Landlord. Landlord shall deliver possession of
Suite 453 in its then as-is condition, vacant, within a commercially-reasonable timeframe of Tenant’s written notice, understanding that Landlord will need to relocate the functions of the suite to another location. Upon Landlord’s
delivery of possession of the Second Expansion Space to Tenant, Tenant’s Lease shall be further amended as follows: 
 a)

 The Rentable Area of the Premises shall be increased by 1,602 square feet to a new total of 9,018 square feet. 

b) 
 Monthly
Base Rent for the Second Expansion Space shall be $5,500.00, increasing three percent (3%) annually. 
 c) 

The Base year for the Second Expansion Space shall be 2007. 

VI. 
 Tenant represents to
Landlord that it has represented itself in this transaction and that no brokerage fee or other such payment shall be due any representative of Tenant as a result hereof. 

Except for those terms outlined above, all other terms and conditions of the base Lease and WorkLetter and Exhibits shall apply.

 In witness hereof, the parties have executed this First Amendment as of the date noted below. 

									
	TENANT:	 		 	LANDLORD:
			
	Zogenix, Inc., a Delaware Corporation.	 		 	Emery Station Joint Venture, LLC, a California Limited Liability
					
	By:	 	 /s/ Stephen J. Farr
	 		 	By:	 	 /s/ [Illegible]

					
	Print Name:	 	 Stephen J. Farr
	 		 	Print Name:	 	 [Illegible]

					
	Its:	 	 President
	 		 	Its:	 	  

					
	Dated:	 	13 July 2007	 		 	Dated:Second Amendment to Lease

 Exhibit 10.12 

SECOND AMENDMENT 

to 
 LEASE BETWEEN

 EMERY STATION JOINT VENTURE, LLC (LANDLORD) 

And 
 ZOGENIX, INC.
(TENANT) 
 EMERYSTATION 1 PROJECT 

Emeryville, California 
 That
certain Lease dated October 31, 2006 by and between Emery Station Joint Venture, LLC, as Landlord, and Zogenix, Inc., as Tenant, as such Lease was amended via First Amendment dated July 10, 2007, (the original Lease and First Amendment
thereto together the “Existing Lease”), is hereby further amended by this Second Amendment whose effective date shall be October 20, 2009 (the “Second Amendment Effective Date”). 

 

	I.	Tenant has requested, and Landlord has agreed, to an expansion of Tenant’s existing 7,416 rentable square foot space (the “Existing Premises”) to include
the 4,702 rentable square foot space located immediately south of the Existing Premises, as outlined in more detail in Exhibit A hereto (the “Second Expansion Space”). 

 

	II.	Landlord will deliver the Second Expansion Space in its as-is condition to Tenant within ten (10) business days of the Second Amendment Effective Date, the date
thereof to be evidenced in writing. This date of such delivery shall be referred to as the “Second Expansion Space Commencement Date”. 

  

	III.	Effective on the Second Expansion Space Commencement Date, the base Lease will be modified as follows (and the Existing Lease and Second Amendment together shall
thereafter be referred to as the Lease for all purposes): 

  

	 	a)	Section 1.1(5) LEASE TERM shall be extended so that the Lease shall expire on September 30, 2015 (the “Expiration Date”). 

 

	 	b)	Section 1.1(8) MONTHLY BASE RENT shall be modified as follows: 

The Second Expansion Space shall bear Monthly Base Rent of $15,845.74 (calculated to be $3.37 per rentable square foot on 4,702 rentable
square feet). Effective October 1, 2011, and annually thereafter, the Monthly Base Rent applicable to the Premises (i.e. to the Existing Premises and to the Second Expansion Space) shall increase by three percent (3%). 

During the first two (2) months following the Second Expansion Space Commencement Date, the Second Expansion Space shall be free of
Monthly Base Rent. 
  

	 	c)	Section 1.1(9) RENTABLE AREA OF THE PREMISES shall become 12,118 square feet and Tenant’s pro-rata share shall be adjusted accordingly.

  

	 	d)	Section 1.1(10) BASE YEAR shall be modified to indicate that the Base Year for both the Existing Premises and the Expansion Premises shall be 2007 and the Base
Year for the Second Expansion Space shall be 2009. Any lab space built into the Existing Premises or the Second Expansion Space shall have electrical measuring devices installed so that any above-standard power usage therein can be separately billed
to Tenant as a separate billing and not as part of Operating Expenses. If Tenant is able to and chooses to connect to any Building lab systems such as air or vacuum, Tenant shall pay its pro-rata share of the costs associated with the operations and
maintenance of such systems separately from Operating Expenses. 

  

	 	e)	Section 1.1(13) PARKING shall be modified such that Tenant shall be entitled to as many as fourteen (14) more non-premium spaces, making the total non-premium
spaces to which they are entitled thirty-three (33). 

	IV.	Upon the Second Expansion Space Commencement Date, Landlord shall make available to Tenant a Tenant Improvement Allowance totaling $305,000.00, which funds Tenant can
use to reimburse itself for valid, documentable third-party costs associated with improvements that Tenant has already made for improvements Tenant will make after the date hereof to the Second Expansion Space, so long as said improvements include
the creation of a lab space in at least a portion of the Premises. Landlord shall advance the Tenant Improvement Allowance to Tenant in one or more installments within fifteen (15) business days of receipt of the evidence of the third-party
costs. In addition to the $305,000.00 Tenant Improvement Allowance referenced above, Landlord agrees to pay 50% of the cost of any “emon-demon” electrical measuring devices necessary to measure electrical usage in the lab portion of the
Premises. 

  

	V.	A new section shall be added to Tenant’s Lease as follows: 

RIGHT OF THIRD EXPANSION: During the first six (6) months following the Second Amendment Effective Date, Tenant may provide a
written notice to Landlord that it intends to lease the 1,602 rentable square foot Suite 453 (the “Third Expansion Space”), which suite is currently being used as a conference room and marketing office by an affiliate of Landlord. Landlord
shall deliver possession of Suite 453 in its then as-is condition, along with the existing Landlord furnishings (but not telephones nor computer equipment) in place, in their as-is condition, within a commercially-reasonable timeframe of
Tenant’s written notice, understanding that Landlord will need to relocate the functions of the suite to another location. Upon Landlord’s delivery of possession of the Third Expansion Space to Tenant, Tenant’s Lease shall be further
amended as follows: 
  

	 	a)	The Rentable Area of the Premises shall be increased by 1,602 square feet to a new total of 13,720 square feet and Tenant’s pro-rata share will be adjusted
accordingly at the same time. 

  

	 	b)	Monthly Base Rent for the Third Expansion Space shall be calculated at the same rental rate per rentable square foot as applies to the Second Expansion Space. Payment
of this Monthly Base Rent for the Third Expansion Space shall entitle Tenant to use the existing Landlord furnishings referenced above at no additional cost during the lease term. Tenant shall reasonably maintain, repair and insure said furnishings
and return them to Landlord at the end of the Lease, normal wear and tear excepted. 

  

	 	c)	The Base year for the Second Expansion Space shall be 2010 

  

	VI.	Article 20 regarding relocation shall continue to prohibit this right by Landlord during the last six months of the Lease Term. 

 

	VII.	Tenant represents to Landlord that it has represented itself in this transaction and that no brokerage fee or other such payment shall be due any representative of
Tenant as a result hereof. 

 Except for those terms outlined above, all other terms and conditions of the Existing Lease and
WorkLetter and Exhibits shall apply. 
 In witness hereof, the parties have executed this First Amendment as of the date noted below.

  

									
	 TENANT:
 Zogenix,
Inc., a California
 Corporation.
	 		 	 LANDLORD:
 Emery
Station Joint Venture, LLC, a
 California Limited Liability Company

					
	By:	 	/s/ Stephen J. Farr	 		 	By:	 	/s/ [Illegible]
	Print Name:	 	Stephen J. Farr	 		 	Print Name: 	 	 
	Its:	 	President	 		 	Its:	 	 
					
	Dated:	 	19 Oct 09	 		 	Dated:	 	10/20/09

 Exhibit A

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