Document:

EX-10.1

 Exhibit 10.1 

AERPIO PHARMACEUTICALS, INC. 

EMPLOYMENT AGREEMENT 
 This
Employment Agreement (“Agreement”) is made between Aerpio Pharmaceuticals, Inc., a Delaware corporation (the “Company”), and Regina Marek, CPA MBA (the “Executive”) and is effective as of November 6, 2019,
(the “Effective Date”). Except with respect to the Proprietary Rights Agreement and the Equity Documents (each as defined below), this Agreement supersedes in all respects all prior agreements between the Executive and the Company
regarding the subject matter herein, including without limitation (i) the offer letter between the Company and the Executive dated July 15, 2018 (the “Prior Agreement”), (ii) any offer letter, employment agreement or severance
agreement and (iii) any retention or severance notice. 
 WHEREAS, the Company desires to continue to employ the Executive and the
Executive desires to continue to be employed by the Company beginning on the Effective Date on the terms of this Agreement and the Proprietary Rights Agreement; 

NOW, THEREFORE, in consideration of the mutual covenants and agreements herein contained and other good and valuable consideration, the
receipt and sufficiency of which is hereby acknowledged, the parties agree as follows: 
 1. Employment. 

(a) Term. The Company agrees to continue to employ the Executive, and the Executive hereby accepts such continued employment commencing
as of the Effective Date and continuing, until terminated in accordance with the provisions of Section 3. The Executive’s employment with the Company shall be “at will,” meaning that the Executive’s employment may be
terminated by the Company or the Executive at any time and for any reason subject to the terms of this Agreement. The time period between the Effective Date and the Date of Termination shall be referred to herein as the “Term”. 

(b) Position and Duties. During the Term, the Executive shall serve as the Vice President of Finance of the Company, shall report to the
Company’s President and Founder and shall have such powers and duties as may from time to time be prescribed by the President and Founder or the Board of Directors of the Company (the “Board”) or other authorized executive, provided
that such duties are consistent with the Executive’s position or other positions that she may hold from time to time. The Executive shall devote substantially all her working time and efforts to the business and affairs of the Company.
Notwithstanding the foregoing, the Executive may serve on up to two (2) boards of directors of companies of her choice, provided the Executive will notify the Board upon joining or leaving any such board. The Executive may also serve on
additional boards of directors, with the approval of the Board, or engage in religious, charitable or other community activities as long as such services and activities (a) are disclosed to the Board when they require a significant time
commitment and (b) do not materially interfere with the Executive’s performance of her duties to the Company as provided in this Agreement. 

 2. Compensation and Related Matters. 

(a) Base Salary. During the Term, the Executive’s initial annual base salary shall be $270,000. The Executive’s base salary
shall be reviewed annually for a potential increase by the Board or the Compensation Committee of the Board (the “Compensation Committee”). The base salary in effect at any given time is referred to herein as “Base
Salary.” The Base Salary shall be payable in a manner that is consistent with the Company’s usual payroll practices for executive officers. 

(b) Incentive Compensation. During the Term, the Executive shall be eligible to receive cash incentive compensation as determined in
good-faith by the Board or the Compensation Committee at least annually. The Executive’s target annual incentive compensation shall be thirty-five percent (35%) of her Base Salary (the “Target Annual Incentive Compensation”);
provided that any incentive compensation awarded for performance between January 1, 2019 and the date immediately prior to the Effective Date shall be pro-rated based on the Executive’s base salary
and target incentive compensation in effect prior to the Effective Date, and any incentive compensation awarded for performance between the Effective Date and December 31, 2019 shall be prorated based on the Base Salary and Target Annual
Incentive Compensation set forth in this Section 2(b). To earn any incentive compensation, the Executive must be employed by the Company on the last day of the applicable year. The Target Annual Incentive Compensation if and to the extent
earned will be paid no later than March 15th of the next succeeding year. 
 (c)
Equity. The equity awards held by the Executive, including without limitation the Retention Grant (as defined below) shall continue to be governed by the terms and conditions of the Company’s applicable equity incentive plan(s) and the
applicable award agreements governing the terms of such equity awards held by the Executive (collectively, the “Equity Documents”); provided, however, and notwithstanding anything to the contrary in the Equity Documents,
Section 4(b)(iii) of this Agreement shall apply in the event of a termination by the Company without Cause or by the Executive for Good Reason, in each case that occurs before the occurrence of the first event constituting a Change in Control
(as such terms are defined below), and Section 5(b) of this Agreement shall apply upon the occurrence of the first event constituting a Change in Control. 

(d) Retention Benefits. The Executive shall continue to be eligible for a cash retention bonus of $120,000, which will be paid on the
next regular payroll date after June 30, 2020, provided that the Executive is employed by the Company on June 30, 2020 (the “Retention Bonus”). For the avoidance of doubt, in the event that the Executive’s employment ends
for any reason prior to June 30, 2020, the Executive shall not be eligible for the Retention Bonus. The Executive shall also continue to be eligible to vest in the retention stock option award granted on May 14, 2019 (the “Retention
Grant”) pursuant to the terms and conditions of the applicable option award agreement and the Company’s 2017 Stock Option and Incentive Plan. 

(e) Expenses. The Executive shall be entitled to receive prompt reimbursement for all reasonable expenses incurred by her during the
Term in performing services hereunder, in accordance with the policies and procedures then in effect and established by the Company for its executive officers. 

  
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 (f) Other Benefits. During the Term, the Executive shall be eligible to participate
in or receive benefits under the Company’s employee benefit plans in effect from time to time, subject to the terms of such plans. 

(g) Vacations. During the Term, the Executive shall be entitled to accrue up to twenty (20) paid vacation days in each year, which
shall be accrued ratably. The Executive shall also be entitled to all paid holidays given by the Company to its executives. 
 3.
Termination. During the Term, the Executive’s employment hereunder may be terminated without any breach of this Agreement under the following circumstances: 

(a) Death. The Executive’s employment hereunder shall terminate upon her death. 

(b) Disability. The Company may terminate the Executive’s employment if she is disabled and unable to perform the essential
functions of the Executive’s then existing position or positions under this Agreement with or without reasonable accommodation for a period of 180 consecutive days or 240 non-consecutive days in any 12-month period. If any question shall arise as to whether during any period the Executive is disabled so as to be unable to perform the essential functions of the Executive’s position with or without
reasonable accommodation, the Executive may, and at the request of the Company shall, submit to the Company a certification in reasonable detail by a physician selected by the Executive as to whether the Executive is so disabled or how long such
disability is expected to continue (provided that if the Company disputes the certification from such physician selected by the Executive, then the Executive will select a second physician reasonably acceptable to the Company and with whom the
Executive has had no prior relationship to provide a new certification, and the original certification from the Executive’s first selected physician will be of no effect), and such certification (from the first or second physician, as the case
may be) shall for the purposes of this Agreement be conclusive of the issue. The Executive shall cooperate with any reasonable request of the physician in connection with such certification. If such question shall arise and the Executive shall fail
to submit such certification, the Company’s determination of such issue shall be binding on the Executive. Nothing in this Section 3(b) shall be construed to waive the Executive’s rights, if any, under law including, without
limitation, the Family and Medical Leave Act of 1993, 29 U.S.C. §2601 et seq. Mass. General Laws Chapter 151B and/or the Americans with Disabilities Act, 42 U.S.C. §12101 et seq. 

(c) Termination by Company for Cause. The Company may terminate the Executive’s employment without notice hereunder for Cause. For
purposes of this Agreement, “Cause” shall mean: (i) conduct by the Executive constituting a material act of misconduct in connection with the performance of her duties; (ii) the commission by the Executive of any felony or a
misdemeanor involving moral turpitude, deceit or fraud, or any conduct by the Executive that would reasonably be expected to result in material injury or material reputational harm to the Company or any of its subsidiaries or affiliates if she were
retained in her position; (iii) a material breach by the Executive of any of the provisions contained in this Agreement or in Section 7 or the Proprietary Rights Agreement; (iv) a material violation by the Executive of the
Company’s written employment policies; or (v) failure to cooperate with a bona fide internal investigation or an investigation by regulatory or law enforcement authorities, after being instructed by the Company to cooperate, or the willful
destruction or willful failure to preserve documents or other materials known to be relevant to such investigation or the inducement of others to fail to cooperate or to produce documents or other materials in connection with such investigation.

  
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 (d) Termination Without Cause. The Company may terminate the Executive’s
employment hereunder at any time without Cause. Any termination by the Company of the Executive’s employment under this Agreement which does not constitute a termination for Cause under Section 3(c) and does not result from the death or
disability of the Executive under Section 3(a) or (b) shall be deemed a termination without Cause. 
 (e) Termination by the
Executive. The Executive may terminate her employment hereunder at any time for any reason, including but not limited to Good Reason. For purposes of this Agreement, “Good Reason” shall mean that the Executive has complied with the
“Good Reason Process” (hereinafter defined) following the occurrence of any of the following events: (i) a material diminution in the Executive’s responsibilities, authority or duties; (ii) a material diminution in the
Executive’s Base Salary except for across-the-board salary reductions based on the Company’s financial performance similarly affecting all or substantially all
senior management employees of the Company; (iii) a more than fifty (50) mile change in the geographic location at which the Executive provides services to the Company; or (iv) the material breach of this Agreement by the Company.
“Good Reason Process” shall mean that (i) the Executive reasonably determines in good faith that a “Good Reason” condition has occurred; (ii) the Executive notifies the Company in writing of the first occurrence of the
Good Reason condition within 60 days of the first occurrence of such condition; (iii) the Executive cooperates in good faith with the Company’s efforts, for a period not less than 30 days following such notice (the “Cure
Period”), to remedy the condition; (iv) notwithstanding such efforts, the Good Reason condition continues to exist; and (v) the Executive terminates her employment within 60 days after the end of the Cure Period. If the Company cures
the Good Reason condition during the Cure Period, Good Reason shall be deemed not to have occurred. 
 (f) Notice of Termination.
Except for termination as specified in Section 3(a), any termination of the Executive’s employment by the Company or any such termination by the Executive shall be communicated by written Notice of Termination to the other party hereto.
For purposes of this Agreement, a “Notice of Termination” shall mean a notice which shall indicate the specific termination provision in this Agreement relied upon. 

(g) Date of Termination. “Date of Termination” shall mean: (i) if the Executive’s employment is terminated by her
death, the date of her death; (ii) if the Executive’s employment is terminated on account of disability under Section 3(b) or by the Company for Cause under Section 3(c), the date on which Notice of Termination is given;
(iii) if the Executive’s employment is terminated by the Company under Section 3(d), the date on which a Notice of Termination is given; (iv) if the Executive’s employment is terminated by the Executive under
Section 3(e) other than for Good Reason, 30 days after the date on which a Notice of Termination is given, and (v) if the Executive’s employment is terminated by the Executive under Section 3(e) for Good Reason, the date on which
a Notice of Termination is given after the end of the Cure Period. Notwithstanding the foregoing, in the event that the Executive gives a Notice of Termination to the Company, the Company may unilaterally accelerate the Date of Termination and such
acceleration shall not result in a termination by the Company for purposes of this Agreement. 

  
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 4. Compensation Upon Termination. 

(a) Termination Generally. If the Executive’s employment with the Company is terminated for any reason by the Executive or the
Company or by death or disability as set forth in this Agreement, the Company shall pay or provide to the Executive (or to her authorized representative or estate) (i) any Base Salary earned through the Date of Termination, (ii) unpaid
expense reimbursements (subject to, and in accordance with, Section 2(e)); (iii) unused vacation that accrued through the Date of Termination; (iv) any vested benefits the Executive may have under any employee benefit plan of the
Company through the Date of Termination, which vested benefits shall be paid and/or provided in accordance with the terms of such employee benefit plans, and (v) any incentive compensation for the year preceding the year in which the Date of
Termination occurs and to be paid to the Executive as provided by Section 2(b) if the Executive had been employed at the end of a calendar year and such compensation has not yet been paid as provided under Section 2(b) (collectively, the
“Accrued Benefit”). 
 (b) Termination by the Company Without Cause or by the Executive for Good Reason. During the Term, if
the Executive’s employment is terminated by the Company without Cause as provided in Section 3(d), or the Executive terminates her employment for Good Reason as provided in Section 3(e), then the Company shall pay the Executive her
Accrued Benefit. In addition, subject to the Executive signing a separation agreement (provided to the Executive on the date of termination or within five (5) business days thereafter) containing, among other provisions, a general release of
claims in favor of the Company and related persons and entities (with reasonable and standard exceptions), confidentiality, return of property and non-disparagement, in a form and manner reasonably
satisfactory to the Company and not containing additional obligations regarding restrictive covenants other than Executive already agreed to (the “Separation Agreement”) and the Separation Agreement becoming irrevocable, all within the
time period set forth in the Separation Agreement but in no event more than 60 days after the Date of Termination: 
 (i) the
Company shall pay the Executive an amount equal to twelve (12) months’ Base Salary (the “Severance Amount”). Notwithstanding the foregoing, if the Executive materially breaches any of the provisions contained in the
Proprietary Rights Agreement or Section 7, all payments of the Severance Amount shall immediately cease; and 
 (ii) if
the Executive was participating in the Company’s group health plan immediately prior to the Date of Termination and elects COBRA health and dental continuation, then the Company shall pay on the Executive’s behalf for twelve
(12) months or the Executive’s COBRA health and dental continuation period, whichever ends earlier, an amount equal to the monthly employer contribution that the Company would have made to provide health and dental insurance to the
Executive if the Executive had remained employed by the Company plus any associated COBRA administrative fees; and 

  
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 (iii) upon the Date of Termination, all time-based stock options and other
time-based stock-based awards held by the Executive in which the Executive would have vested if she had remained employed for an additional twelve (12) months following the Date of Termination shall vest and become exercisable or nonforfeitable
as of the Date of Termination; and 
 (iv) the amounts payable under Section 4(b)(i) and (ii) shall be paid out in
substantially equal installments in accordance with the Company’s payroll practice over twelve (12) months commencing within 60 days after the Date of Termination; provided, however, that if the
60-day period begins in one calendar year and ends in a second calendar year, the Severance Amount shall begin to be paid in the second calendar year by the last day of such
60-day period; provided, further, that the initial payment shall include a catch-up payment to cover amounts retroactive to the day immediately following the Date of
Termination. Each payment pursuant to this Agreement is intended to constitute a separate payment for purposes of Treasury Regulation Section 1.409A-2(b)(2). 

5. Change in Control. The provisions of this Section 5 set forth certain terms of an agreement reached between the Executive and
the Company regarding the Executive’s rights and obligations upon the occurrence of a Change in Control of the Company. These provisions shall apply in lieu of, and expressly supersede the provisions of Section 4(b), upon a Change of
Control and if a termination of employment occurs within fifteen (15) months after the occurrence of the first event constituting a Change in Control. These provisions shall terminate and be of no further force or effect beginning fifteen
(15) months after the occurrence of a Change in Control. 
 (a) Change in Control Payments. During the Term, if within fifteen
(15) months after a Change in Control, the Executive’s employment is terminated by the Company without Cause as provided in Section 3(d) or the Executive terminates her employment for Good Reason as provided in Section 3(e),
then, subject to the signing of the Separation Agreement (given to the Executive within five (5) business days after the Date of Termination) by the Executive and the Separation Agreement becoming irrevocable and fully effective, all within 60
days after the Date of Termination, 
 (i) the Company shall pay the Executive a lump sum in cash in an amount equal to
one and a half (1.5) times the sum of both (A) the Executive’s current Base Salary (or the Executive’s Base Salary in effect immediately prior to the Change in Control, if higher) plus (B) the Executive’s Target
Incentive Annual Compensation (or the Executive’s Target Incentive Annual Compensation in effect immediately prior to the Change in Control, if larger); and 

(ii) if the Executive was participating in the Company’s group health plan immediately prior to the Date of Termination
and elects COBRA health continuation, then the Company shall pay to the Executive a monthly cash payment for eighteen (18) months or the Executive’s COBRA health continuation period, whichever ends earlier, in an amount equal to the
monthly employer contribution that the Company would have made to provide health and dental insurance to the Executive if the Executive had remained employed by the Company; and 

  
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 (iii) the amounts payable under this Section 5(a) shall be paid or
commence to be paid within 60 days after the Date of Termination; provided, however, that if the 60-day period begins in one calendar year and ends in a second calendar year, such payment shall be paid or
commence to be paid in the second calendar year by the last day of such 60-day period. 
 (b)
Equity Post-Change of Control. Notwithstanding anything contrary in any applicable option agreement or other stock-based award agreement, all stock options and other stock-based awards of the Company held by the Executive subject to
time-based vesting shall immediately accelerate and become fully exercisable or nonforfeitable upon the occurrence of the first event constituting a Change in Control. 

(c) Additional Limitation. 

(i) Anything in this Agreement to the contrary notwithstanding, in the event that the amount of any compensation, payment or
distribution by the Company to or for the benefit of the Executive, whether paid or payable or distributed or distributable pursuant to the terms of this Agreement or otherwise, calculated in a manner consistent with Section 280G of the
Internal Revenue Code of 1986, as amended (the “Code”) and the applicable regulations thereunder (the “Aggregate Payments”), would be subject to the excise tax imposed by Section 4999 of the Code, then the Aggregate Payments
shall be reduced (but not below zero) so that the sum of all of the Aggregate Payments shall be $1.00 less than the amount at which the Executive becomes subject to the excise tax imposed by Section 4999 of the Code; provided that such
reduction shall only occur if it would result in the Executive receiving a higher After Tax Amount (as defined below) than the Executive would receive if the Aggregate Payments were not subject to such reduction. In such event, the Aggregate
Payments shall be reduced in the following order, in each case, in reverse chronological order beginning with the Aggregate Payments that are to be paid the furthest in time from consummation of the transaction that is subject to Section 280G
of the Code: (1) cash payments not subject to Section 409A of the Code; (2) cash payments subject to Section 409A of the Code; (3) equity-based payments and acceleration; and
(4) non-cash forms of benefits; provided that in the case of all the foregoing Aggregate Payments all amounts or payments that are not subject to calculation under Treas. Reg. §1.280G-1, Q&A-24(b) or (c) shall be reduced before any amounts that are subject to calculation under Treas. Reg.
§1.280G-1, Q&A-24(b) or (c). 
 (ii)
For purposes of this Section 5(c), the “After Tax Amount” means the amount of the Aggregate Payments less all federal, state, and local income, excise and employment taxes imposed on the Executive as a result of the Executive’s
receipt of the Aggregate Payments. For purposes of determining the After Tax Amount, the Executive shall be deemed to pay federal income taxes at the highest marginal rate of federal income taxation applicable to individuals for the calendar year in
which the determination is to be made, and state and local income taxes at the highest marginal rates of individual taxation in each applicable state and locality, net of the maximum reduction in federal income taxes which could be obtained from
deduction of such state and local taxes. 

  
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 (iii) The determination as to whether a reduction in the Aggregate Payments
shall be made pursuant to Section 5(c)(i) shall be made by a nationally recognized accounting firm selected by the Company (the “Accounting Firm”), which shall provide detailed supporting calculations both to the Company and the
Executive within 15 business days of the Date of Termination, if applicable, or at such earlier time as is reasonably requested by the Company or the Executive. Any determination by the Accounting Firm shall be binding upon the Company and the
Executive. 
 (d) Definitions. For purposes of this Section 5, the following terms shall have the following meanings: 

“Change in Control” shall mean any of the following: 

(i) any “person,” as such term is used in Sections 13(d) and 14(d) of the Securities Exchange Act of 1934, as amended
(the “Act”) (other than the Company, any of its subsidiaries, or any trustee, fiduciary or other person or entity holding securities under any employee benefit plan or trust of the Company or any of its subsidiaries), together with all
“affiliates” and “associates” (as such terms are defined in Rule 12b-2 under the Act) of such person, shall become the “beneficial owner” (as such term is defined in Rule 13d-3 under the Act), directly or indirectly, of securities of the Company representing 50 percent or more of the combined voting power of the Company’s then outstanding securities having the right to vote
in an election of the Board (“Voting Securities”) (in such case other than as a result of an acquisition of securities directly from the Company); or 

(ii) the date a majority of the members of the Board is replaced during any 12-month
period by directors whose appointment or election is not endorsed by a majority of the members of the Board before the date of the appointment or election; or 

(iii) the consummation of (A) any consolidation or merger of the Company where the stockholders of the Company,
immediately prior to the consolidation or merger, would not, immediately after the consolidation or merger, beneficially own (as such term is defined in Rule 13d-3 under the Act), directly or indirectly,
shares representing in the aggregate more than 50 percent of the voting shares of the Company issuing cash or securities in the consolidation or merger (or of its ultimate parent corporation, if any), or (B) any sale or other transfer (in
one transaction or a series of transactions contemplated or arranged by any party as a single plan) of all or substantially all of the assets of the Company. 

Notwithstanding the foregoing, a “Change in Control” shall not be deemed to have occurred for purposes of the foregoing clause
(i) solely as the result of an acquisition of securities by the Company which, by reducing the number of shares of Voting Securities outstanding, increases the proportionate number of Voting Securities beneficially owned by any person to
50 percent or more of the combined voting power of all of the then outstanding Voting 

  
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Securities; provided, however, that if any person referred to in this sentence shall thereafter become the beneficial owner of any additional shares of Voting Securities (other than pursuant to a
stock split, stock dividend, or similar transaction or as a result of an acquisition of securities directly from the Company) and immediately thereafter beneficially owns 50 percent or more of the combined voting power of all of the then
outstanding Voting Securities, then a “Change in Control” shall be deemed to have occurred for purposes of the foregoing clause (i). 

6. Section 409A. 

(a) Anything in this Agreement to the contrary notwithstanding, if at the time of the Executive’s separation from service within the
meaning of Section 409A of the Code, the Company determines that the Executive is a “specified employee” within the meaning of Section 409A(a)(2)(B)(i) of the Code, then to the extent any payment or benefit that the Executive
becomes entitled to under this Agreement on account of the Executive’s separation from service would be considered deferred compensation otherwise subject to the 20 percent additional tax imposed pursuant to Section 409A(a) of the
Code as a result of the application of Section 409A(a)(2)(B)(i) of the Code, such payment shall not be payable and such benefit shall not be provided until the date that is the earlier of (A) six months and one day after the
Executive’s separation from service, or (B) the Executive’s death. If any such delayed cash payment is otherwise payable on an installment basis, the first payment shall include a catch-up
payment covering amounts that would otherwise have been paid during the six-month period but for the application of this provision, and the balance of the installments shall be payable in accordance with their
original schedule. 
 (b) All in-kind benefits provided and expenses eligible for reimbursement under
this Agreement shall be provided by the Company or incurred by the Executive during the time periods set forth in this Agreement. All reimbursements shall be paid as soon as administratively practicable, but in no event shall any reimbursement be
paid after the last day of the taxable year following the taxable year in which the expense was incurred. The amount of in-kind benefits provided or reimbursable expenses incurred in one taxable year shall not
affect the in-kind benefits to be provided or the expenses eligible for reimbursement in any other taxable year (except for any lifetime or other aggregate limitation applicable to medical expenses). Such
right to reimbursement or in-kind benefits is not subject to liquidation or exchange for another benefit. 

(c) To the extent that any payment or benefit described in this Agreement constitutes
“non-qualified deferred compensation” under Section 409A of the Code, and to the extent that such payment or benefit is payable upon the Executive’s termination of employment, then such
payments or benefits shall be payable only upon the Executive’s “separation from service.” The determination of whether and when a separation from service has occurred shall be made in accordance with the presumptions set forth in
Treasury Regulation Section 1.409A-1(h). 
 (d) The parties intend that this Agreement shall be
administered in accordance with Section 409A of the Code. To the extent that any provision of this Agreement is ambiguous as to its compliance with Section 409A of the Code, the provision shall be read in such a manner so that all payments
hereunder comply with Section 409A of the Code. Each payment pursuant 

  
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to this Agreement is intended to constitute a separate payment for purposes of Treasury Regulation Section 1.409A-2(b)(2). The parties agree that this
Agreement may be amended, as reasonably requested by either party, and as may be necessary to fully comply with Section 409A of the Code and all related rules and regulations in order to preserve the payments and benefits provided hereunder
without additional cost to either party. 
 (e) The Company makes no representation or warranty and shall have no liability to the Executive
or any other person if any provisions of this Agreement are determined to constitute deferred compensation subject to Section 409A of the Code but do not satisfy an exemption from, or the conditions of, such Section. 

7. Confidential Information, Noncompetition and Cooperation. 

(a) Proprietary Rights Agreement. The terms of the Employee Confidentiality and Assignment Agreement between the Company and the
Executive dated November 4, 2019 and attached hereto as Exhibit A (the “Proprietary Rights Agreement”) and the Confidentiality and Non-Disclosure Agreement dated August 1, 2018 (the “Confidentiality Agreement”) shall
continue to be in full force and effect and are incorporated by reference as material terms of this Agreement. 
 (b) Third-Party
Agreements and Rights. The Executive hereby confirms that the Executive is not bound by the terms of any agreement with any previous employer or other party which restricts in any way the Executive’s use or disclosure of information or the
Executive’s engagement in any business. The Executive represents to the Company that the Executive’s execution of this Agreement, the Executive’s employment with the Company and the performance of the Executive’s proposed duties
for the Company shall not violate any obligations the Executive may have to any such previous employer or other party. In the Executive’s work for the Company, the Executive shall not disclose or make use of any information in violation of any
agreements with or rights of any such previous employer or other party, and the Executive shall not bring to the premises of the Company any copies or other tangible embodiments of non-public information
belonging to or obtained from any such previous employment or other party. 
 (c) Litigation and Regulatory Cooperation. During and
after the Executive’s employment, the Executive shall cooperate fully with the Company in the defense or prosecution of any claims or actions now in existence or which may be brought in the future against or on behalf of the Company which
relate to events or occurrences that transpired while the Executive was employed by the Company. The Executive’s full cooperation in connection with such claims or actions shall include, but not be limited to, being available to meet with
counsel to prepare for discovery or trial and to act as a witness on behalf of the Company at mutually convenient times. During and after the Executive’s employment, the Executive also shall cooperate fully with the Company in connection with
any investigation or review of any federal, state or local regulatory authority as any such investigation or review relates to events or occurrences that transpired while the Executive was employed by the Company. The Company shall reimburse the
Executive for any reasonable out-of-pocket expenses incurred in connection with the Executive’s performance of obligations pursuant to this Section 7(c). 

  
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 (d) Relief. The Executive agrees that it would be difficult to measure any damages
caused to the Company which might result from any breach by the Executive of the promises set forth in this Section 7, and that in any event money damages would be an inadequate remedy for any such material breach. Accordingly, notwithstanding
Section 8 of this Agreement, the Executive agrees that if the Executive materially breaches, or proposes to materially breach, any portion of this Agreement, the Company shall be entitled, in addition to all other remedies that it may have, to
an injunction or other appropriate equitable relief to restrain any such breach without showing or proving any actual damage to the Company. In addition, in the event the Executive materially breaches this Section 7 during a period when she is
receiving severance payments pursuant to Section 4 or Section 5 hereof, the Company shall have the right to suspend or terminate such severance payments. Such suspension or termination shall not limit the Company’s other options with
respect to relief for such breach and shall not relieve the Executive of her duties under this Agreement. 
 (e) Protected Disclosures and
Other Protected Action. Nothing contained in this Agreement limits the Executive’s ability to file a charge or complaint with any federal, state or local governmental agency or commission (a “Government Agency”). In addition,
nothing contained in this Agreement limits the Executive’s ability to communicate with any Government Agency or otherwise participate in any investigation or proceeding that may be conducted by any Government Agency, including the
Executive’s ability to provide documents or other information, without notice to the Company, nor do any of the provisions of this Section 7 apply to truthful testimony in litigation. If the Executive files any charge or complaint with any
Government Agency and if the Government Agency pursues any claim on the Executive’s behalf, or if any other third party pursues any claim on the Executive’s behalf, the Executive waives any right to monetary or other individualized relief
(either individually, or as part of any collective or class action); provided that nothing in this Agreement limits any right the Executive may have to receive a whistleblower award or bounty for information provided to the Securities and Exchange
Commission. 
 8. Arbitration of Disputes. Any controversy or claim arising out of or relating to this Agreement or the breach thereof
or otherwise arising out of the Executive’s employment or the termination of that employment (including, without limitation, any claims of unlawful employment discrimination whether based on age or otherwise) shall, to the fullest extent
permitted by law, be settled by arbitration in any forum and form mutually agreed upon by the parties or, in the absence of such an agreement, under the auspices of the American Arbitration Association (“AAA”) in Boston, Massachusetts in
accordance with the Employment Dispute Resolution Rules of the AAA, including, but not limited to, the rules and procedures applicable to the selection of arbitrators. In the event that any person or entity other than the Executive or the Company
may be a party with regard to any such controversy or claim, such controversy or claim shall be submitted to arbitration subject to such other person or entity’s agreement. Judgment upon the award rendered by the arbitrator may be entered in
any court having jurisdiction thereof. This Section 8 shall be specifically enforceable. Notwithstanding the foregoing, this Section 8 shall not preclude either party from pursuing a court action for the sole purpose of obtaining a
temporary restraining order or a preliminary injunction in circumstances in which such relief is appropriate; provided that any other relief shall be pursued through an arbitration proceeding pursuant to this Section 8. 

  
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 9. Consent to Jurisdiction. To the extent that any court action is permitted
consistent with or to enforce Section 8, the parties hereby consent to the jurisdiction of the Superior Court of The Commonwealth of Massachusetts and the United States District Court for the District of Massachusetts. Accordingly, with respect
to any such court action, the Executive (a) submits to the personal jurisdiction of such courts; (b) consents to service of process; and (c) waives any other requirement (whether imposed by statute, rule of court, or otherwise) with
respect to personal jurisdiction or service of process. 
 10. Integration. This Agreement, the Proprietary Rights Agreement, the
Confidentiality Agreement and the Equity Documents constitute the entire agreement between the parties with respect to the subject matter hereof and supersede all prior agreements between the parties concerning such subject matter, including without
limitation the Prior Agreement and the retention benefits letter dated September 2019. 
 11. Withholding. All payments made by the
Company to the Executive under this Agreement shall be net of any tax or other amounts required to be withheld by the Company under applicable law. 

12. Successor to the Executive. This Agreement shall inure to the benefit of and be enforceable by the Executive’s personal
representatives, executors, administrators, heirs, distributees, devisees and legatees. In the event of the Executive’s death after her termination of employment but prior to the completion by the Company of all payments due her under this
Agreement, the Company shall continue such payments to the Executive’s beneficiary designated in writing to the Company prior to her death (or to her estate, if the Executive fails to make such designation). 

13. Enforceability. If any portion or provision of this Agreement (including, without limitation, any portion or provision of any
section of this Agreement) shall to any extent be declared illegal or unenforceable by a court of competent jurisdiction, then the remainder of this Agreement, or the application of such portion or provision in circumstances other than those as to
which it is so declared illegal or unenforceable, shall not be affected thereby, and each portion and provision of this Agreement shall be valid and enforceable to the fullest extent permitted by law. 

14. Survival. The provisions of this Agreement shall survive the termination of this Agreement and/or the termination of the
Executive’s employment to the extent necessary to effectuate the terms contained herein. 
 15. Waiver. No waiver of any
provision hereof shall be effective unless made in writing and signed by the waiving party. The failure of any party to require the performance of any term or obligation of this Agreement, or the waiver by any party of any breach of this Agreement,
shall not prevent any subsequent enforcement of such term or obligation or be deemed a waiver of any subsequent breach. 
 16.
Notices. Any notices, requests, demands and other communications provided for by this Agreement shall be sufficient if in writing and delivered in person or sent by a nationally recognized overnight courier service or by registered or
certified mail, postage prepaid, return receipt requested, to the Executive at the last address the Executive has filed in writing with the Company or, in the case of the Company, at its main offices, attention of the Board. 

  
 12 

 17. Amendment. This Agreement may be amended or modified only by a written instrument
signed by the Executive and by a duly authorized representative of the Company. 
 18. Governing Law. This is an Ohio contract and
shall be construed under and be governed in all respects by the laws of State of Ohio, without giving effect to the conflict of laws principles thereof. With respect to any disputes concerning federal law, such disputes shall be determined in
accordance with the law as it would be interpreted and applied by the United States Court of Appeals for the Sixth Circuit. 
 19.
Counterparts. This Agreement may be executed in any number of counterparts, each of which when so executed and delivered shall be taken to be an original; but such counterparts shall together constitute one and the same document. 

20. Successor to Company. The Company shall require any successor (whether direct or indirect, by purchase, merger, consolidation or
otherwise) to all or substantially all of the business or assets of the Company expressly to assume and agree to perform this Agreement, including Section 4, to the same extent that the Company would be required to perform it if no succession
had taken place. Failure of the Company to obtain an assumption of this Agreement at or prior to the effectiveness of any succession shall be a material breach of this Agreement. 

21. Gender Neutral. Wherever used herein, a pronoun in the masculine gender shall be considered as including the feminine gender unless
the context clearly indicates otherwise. 
 IN WITNESS WHEREOF, the parties have executed this Agreement effective on the date and year
first above written. 
  

			
	AERPIO PHARMACEUTICALS, INC.

 
			
		
	By:	 	 /s/ Joseph Gardner

	Its:	 	 President

 
			
	
	EXECUTIVE
	
	 /s/ Regina Marek

	Regina Marek, CPA MBA

  
 13 

 EXHIBIT A 

Proprietary Rights AgreementEX-10.1

 Exhibit 10.1 

RETIREMENT AND GENERAL RELEASE AGREEMENT 

THIS RETIREMENT AND GENERAL RELEASE AGREEMENT (the “Agreement”) is entered into as of the last date on the signature page
hereto (the “Execution Date”) by and between ACI Worldwide, Inc., a Delaware corporation (the “Company”), and Philip G. Heasley (“you”) (together, the “Parties”). 

R E C I T A L S 

WHEREAS, you are employed by the Company as President and Chief Executive Officer, pursuant to that certain amended and restated employment
agreement between you and the Company, dated January 7, 2016 (the “Employment Agreement”), which supersedes all prior employment agreements between you and the Company; and 

WHEREAS, the Parties mutually agree to establish the terms of your retirement and separation from employment with the Company, effective as of
December 31, 2019. 
 NOW THEREFORE, in consideration of the mutual covenants and agreements set forth hereinafter, and for other good
and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the Parties, intending to be legally bound, hereby agree as follows: 

AGREEMENT 

1.    RETIREMENT AND SEPARATION OF EMPLOYMENT. Your retirement and separation from employment with the Company as
President and Chief Executive Officer shall occur on December 31, 2019 (the “Separation Date”). You agree that you shall resign from your employment as an officer of the Company, as a member of the Company’s Board of
Directors, and from any and all other positions you may hold with the Company (and its Affiliates) effective as of the Separation Date, and you agree that you will execute any and all documents necessary to effect such resignation(s). For purposes
of this Agreement, “Affiliate” of any particular entity or person means any other entity or person controlling, controlled by or under common control with such particular entity or person, where “control” means the
possession, directly or indirectly, of the power to direct the management and policies of an entity or person whether through the ownership of voting securities, contract or otherwise. Any entity or person with beneficial ownership of more than
20% of the voting power of another entity or person shall be deemed to be an Affiliate of such entity or person. 

2.    TRANSITION AND CONSULTING PERIODS. 

a.    During the period commencing on the Execution Date and ending on the Separation Date (the “Transition
Period”), you hereby agree to provide such transition duties as may be requested by and at the direction of the Company’s Board of Directors (the “Board”), including, without limitation, assisting the Company with the
review of its strategy and key relationships; provided, that, during the Transition Period and in connection with such transition duties, Craig Saks, the Company’s Senior Executive Vice President and Chief Operating Officer, shall be
delegated responsibility for the oversight of the Company’s day-to-day operations in such capacity as would otherwise be performed by the position of Chief
Executive Officer of the 

 
Company, and your direct reports shall report to Mr. Saks until a successor to the Chief Executive Officer position has been appointed; provided, further, that any hiring,
promotion, termination or other change in employment status of any executive officer of the Company shall be subject to prior approval of the Board (the “Transition Duties”). The Board has asked Adalio T. Sanchez, member of the
Board, along with other members of the Board, as appropriate, to provide primary board oversight and assistance to Mr. Saks and other members of management during the Transition Period. You hereby acknowledge and agree that you will use your
best efforts to professionally, timely and cooperatively perform such Transition Duties. You further acknowledge and agree that any communication by you with the Company’s investors or other third parties during the Transition Period shall be
consistent with any Company communications protocol established by the Board regarding the same subject matter. During the Transition Period, you will continue to receive your current base salary and be eligible to participate in the Company’s
employee benefit plans, subject to the terms and conditions of such plans. In addition, the Company will continue to provide you with ongoing secretarial support from Michelle Watson during the Transition Period. You further acknowledge and agree
that you hereby voluntarily and irrevocably waive any and all rights that you may have to terminate your employment with the Company for Good Reason (as defined in the Employment Agreement) or receive severance payments and benefits by reason of
such termination pursuant to the Employment Agreement by reason of any change to your title, duties, authority or reporting relationship that may result from the transition of your duties under this Section 2(a) at any time during the
Transition Period. 
 b.    During the period commencing on the Separation Date and ending on March 31, 2020 (the
“Consulting Period”), you hereby agree to provide consulting services in accordance with the terms and conditions of the consulting agreement set forth in Exhibit A attached hereto. 

3.    ACCRUED OBLIGATIONS. Whether or not you sign this Agreement, you shall be paid on the Company’s first
regularly scheduled payroll date that occurs following the Separation Date (or earlier, to the extent required by applicable law) the aggregate amount of your earned but unpaid base salary, accrued but unpaid vacation pay (to the extent required
under applicable law) and unreimbursed expenses, in each case, through the Separation Date, less applicable taxes and withholding. 

4.    TRANSITION AND SEPARATION BENEFITS. 

a.    The Parties hereby acknowledge and agree that the payments and benefits provided under this Section 4 are in
lieu of any severance pay or benefits to which you may otherwise be entitled pursuant to Section 6(c) of the Employment Agreement, and you hereby waive any right that you may otherwise have with respect to any such severance pay and benefits.
The Company shall, concurrently herewith, provide you with a true and complete summary of all equity awards to acquire shares of the Company’s common stock held by you as of the date hereof as certified by the Secretary of the Company. As good
and valuable consideration in exchange for the general release of claims included in Section 6 of this Agreement and your continued performance of the Transition Duties, during the Transition Period you shall continue to receive your current
base salary and be eligible to participate in the Company’s employee benefit plans, subject to the terms and conditions of such plans. 

  
 2 

 b.    Provided, further, that you (i) execute and return the
Supplemental Release of Claims, as set forth in Exhibit B attached hereto (the “Supplemental Release of Claims”), to the Company within twenty-one (21) calendar days immediately
following the Separation Date and (ii) do not timely revoke the Supplemental Release of Claims, you shall be entitled to receive the payments and benefits on or after the Supplemental Release Effective Date (as defined in the Supplemental
Release of Claims), as set forth below: 
 (i)    The Company shall pay you a
lump-sum cash payment in an amount equal to the annual bonus to which you may have otherwise been entitled for the Company’s 2019 fiscal year, but for your termination of employment with the Company,
based on the extent to which the applicable Company and individual performance goals are actually achieved for such fiscal year and which shall take into account your performance in connection with the Company’s acquisition of Speedpay and
investment in Mindgate Solutions. Payment of such bonus will be made on the Company’s first regularly scheduled payroll date that occurs following the Supplemental Release Effective Date, subject to applicable taxes and withholding
requirements; 
 (ii)    With respect to the grant of performance share units (the “PSUs”) made on
March 4, 2019, this grant will remain outstanding and you will be eligible to earn and vest in a number of PSUs equal to the number of PSUs to which you would have otherwise been entitled based on actual performance of the Company for the full
performance period as if you had remained in continuous employment through the end of the performance period, with any remaining unearned PSUs to be forfeited for no consideration, as determined pursuant to the terms set forth in the underlying
award agreement evidencing such grant; 
 (iii)    With respect to each of the grants of PSUs made on February 21,
2017 (two grants) and February 20, 2018 (one grant), each of these grants will remain outstanding and you will be eligible to earn and vest in a pro-rated number of PSUs, calculated by multiplying
(i) the number of PSUs to which you would have otherwise been entitled based on actual performance of the Company for the full performance period, by (ii) a fraction, the numerator of which is the number of full fiscal quarters you were
employed during the performance period, and the denominator of which is the number of full fiscal quarters in the performance period, with any remaining unearned PSUs to be forfeited for no consideration, as determined pursuant to the terms set
forth in the underlying award agreement evidencing the applicable grant; 
 (iv)    With respect to the grant of
restricted stock units (“RSUs”) made on March 4, 2019, the vesting of 17,514 of the RSUs thereunder will occur on March 4, 2020 (as if your employment with the Company had otherwise continued through such date), with
settlement to occur as soon as practicable and in no event later than 30 days after such date pursuant to the terms set forth in the underlying award agreement, and the remaining 35,026 RSUs thereunder will be forfeited for no consideration as of
the Separation Date; and 
 (v)    Any unvested stock options held by you as of immediately prior to the Separation
Date will continue to vest in accordance with the applicable vesting schedule set forth in the underlying option agreement evidencing such stock options as if your employment had otherwise continued through each applicable vesting date, and will be
exercisable until the 

  
 3 

 
date that is ninety (90) calendar days following the applicable vesting date. Any vested and exercisable stock options held by you as of the Separation Date will remain exercisable until the
date that is ninety (90) calendar days following the Separation Date pursuant to the terms set forth in the underlying option agreement evidencing such stock options. 

5.    OTHER EQUITY AWARDS. The Parties acknowledge and agree that, with respect to the grant of PSUs made on
February 23, 2016, all of the then-outstanding PSUs under such grant will be forfeited for no consideration on the Separation Date. 

6.    RELEASE AND WAIVER. 

a.    You hereby forever release and discharge the Company and its parents, and their Affiliates, successors, and assigns,
as well as each of their past and present officers, directors, employees, agents, attorneys, and stockholders (collectively, the “Company Released Parties”), from any and all claims, charges, complaints, liens, demands, causes of
action, obligations, damages, and liabilities, known or unknown, suspected or unsuspected, that you had, now have, or may hereafter claim to have against the Company Released Parties arising out of, or relating in any way to,
(i) any act or omission from the beginning of time to the Execution Date, including, without limitation, any and all claims or causes of action for wrongful termination, breach of an express or implied contract, breach of the covenant of good
faith and fair dealing, breach of fiduciary duty, fraud, misrepresentation, defamation, slander, infliction of emotional distress, disability, loss of future earnings, and any claims under any applicable state, federal, or local statutes and
regulations, including, but not limited to, the Civil Rights Act of 1964, as amended, the Equal Pay Act of 1963, as amended, the Fair Labor Standards Act, as amended, the Americans with Disabilities Act of 1990, as amended, the Rehabilitation Act of
1973, as amended, the Employee Retirement Income Security Act of 1974, as amended, the Worker Adjustment and Retraining Notification Act, as amended, the Fair Credit Reporting Act, Section 806 of the Sarbanes-Oxley Act, the Dodd-Frank Act, the
Family and Medical Leave Act, as amended, and the Nebraska Fair Employment Practice Act (Neb. Rev. St. §§ 48-1101 to 48-1125); the Nebraska Age Discrimination
in Employment Act (Neb. Rev. St. §§ 48-1001 to 48-1010); the Nebraska Wage Payment and Collection Act (Neb. Rev. St. §§ 48-1228 to 48-1234); Nebraska’s privacy laws (Neb. Rev. St. §§ 20-201 to 20-211
and 25-840.01); Nebraska’s drug testing laws (Neb. Rev. St. §§ 48-1901 to 48-1910); Nebraska’s military leave
laws (Neb. Rev. St. §§ 55-160 to 55-166 and 55-501 to 55-507); Nebraska laws
related to equal pay (Neb. Rev. St. §§ 48-1219 to 48-1227.01); and Nebraska leave laws (Neb. Rev. St. §§
25-1640, 32-922, 48-234, 32-241, and 35-1403 to 35-1405), (ii) your employment prior to the Execution Date or the termination of your employment from the Company or (iii) any arrangement or understanding, including the Employment Agreement, between you and
the Company; provided, however, that this Release does not waive, release or otherwise discharge (A) any claim or cause of action arising from a breach by the Company of this Agreement or that cannot legally be waived, including,
but not limited to, any claim for unpaid wages, workers’ compensation benefits, unemployment benefits or (B) any rights to indemnification under the indemnification agreement between you and the Company, dated March 11, 2009 (the
“Indemnification Agreement”) or applicable law (the “Excluded Claims”).  

  
 4 

 b.    You further acknowledge and agree that, except with respect to the
Excluded Claims, the Company Released Parties have fully satisfied any and all obligations whatsoever owed to you arising out of your employment with the Company or any other Company Released Party, and that no further payments or benefits are owed
to you by the Company or any other Company Party. 
 7.    CONSULTATION WITH ATTORNEY/VOLUNTARY AGREEMENT. You
acknowledge that (a) the Company has advised you of your right to consult with an attorney of your own choosing, to the extent you wish to do so, prior to executing this Agreement, (b) you have carefully read and fully understand all of
the provisions of this Agreement, (c) you are entering into this Agreement, including the releases set forth in this Agreement, knowingly, freely and voluntarily in exchange for good and valuable consideration that is in addition to any
consideration you would otherwise be entitled to receive, and (d) the release in this Agreement applies to and covers all claims against the Company and the other Company Released Parties, whether or not you know or suspect them to exist at the
present time. 
 8.    CONTINUING OBLIGATIONS AND COVENANTS. 

a.    You hereby acknowledge that you will continue to be bound by the surviving terms of the Employment Agreement,
including the terms in Section 8 therein (Competitive Activity; Confidentiality; Nonsolicitation), as set forth and modified below: 

(i)    During the Transition Period, you will not compete with the Company anywhere in the world. In accordance with this
restriction, but without limiting its terms, during the Transition Period, you will not: 
  

	 	(A)	 enter into or engage in any business which directly competes with the business of the Company;

  

	 	(B)	 solicit customers, business, patronage or orders for, or sell, any products and services in competition with,
or for any business that directly competes with, the business of the Company; 

  

	 	(C)	 divert, entice or otherwise take away any customers, business, patronage or orders of the Company or attempt to
do so; or 

  

	 	(D)	 promote or assist, financially or otherwise, any person, firm, association, partnership, corporation or other
entity engaged in any business which directly competes with the business of the Company. 

(ii)    For a period of one (1) year following the Separation Date, you will not: 

 

	 	(A)	 enter into or engage in any business which directly competes with the Company’s business within the
Restricted Territory (as defined below); 

  
 5 

	 	(B)	 solicit customers, business, patronage or orders for, or sell, any products and services in direct competition
with, or for any business, wherever located, that directly competes with, the Company’s business within the Restricted Territory; 

  

	 	(C)	 divert, entice or otherwise take away any customers, business, patronage or orders of the Company within the
Restricted Territory, or attempt to do so; or 

  

	 	(D)	 promote or assist, financially or otherwise, any person, firm, association, partnership, corporation or other
entity engaged in any business which directly competes with the Company’s business within the Restricted Territory. 

(iii)    For the purposes of Sections 8(a)(i) and 8(a)(ii) of this Agreement, but without limitation thereof, you will be
in violation thereof if you engage in any or all of the activities set forth therein directly as an individual on your own account, or indirectly as a partner, joint venturer, employee, agent, salesperson, consultant, officer and/or director of any
firm, association, partnership, corporation or other entity, or as a stockholder of any corporation or the owner of the interests in any other entity, in which you or your spouse, child or parent owns, directly or indirectly, individually or in the
aggregate, more than five percent (5%) of the outstanding stock or other ownership interests; provided, however, that nothing in Sections 8(a)(i) and 8(a)(ii) of this Agreement shall prohibit or otherwise restrict you from serving on
the board of, or as a consultant to, a financial institution, such as a bank. 
 (iv)    For purposes of this
Section 8, the Company shall include any and all direct and indirect subsidiary, parent, affiliated, or related companies of the Company. 

(v)     For the purposes of Sections 8(a)(i), 8(a)(ii) and 8(a)(ix)-(xii) of this Agreement, the Company’s business
is defined to be the development and sale of software products, provision of service and outsourcing of applications that facilitate electronic payments, as further described in any and all manufacturing, marketing and sales manuals and materials of
the Company as the same may be altered, amended, supplemented or otherwise changed from time to time, or of any other products or services substantially similar to or readily suitable for any such described products and services. 

(vi)    For purposes of Section 8(a)(ii) of this Agreement, the Restricted Territory shall be defined as and limited
to: (A) the geographic area(s) within a 100 mile radius of any and all Company location(s) in, to, or for which you worked, to which you were assigned or had any responsibility (either direct or supervisory) as of the Separation Date and at any
time during the one (1) year period prior to the Separation Date; and (B) all of the specific customer accounts, whether within or outside of the geographic area described in (A) above, with which you had any contact or for which you
had any responsibility (either direct or supervisory) as of the Separation Date and at any time during the one (1) year period prior to the Separation Date. 

  
 6 

 (vii)    If it shall be judicially determined that you have violated
any of your obligations under Section 8(a)(ii) of this Agreement, then the period applicable to each obligation that you shall have been determined to have violated shall automatically be extended by a period of time equal in length to the
period during which such violation(s) occurred. 
 (viii)    For a period of two (2) years following the
Separation Date, you will not directly or indirectly solicit or induce or attempt to solicit or induce any employee(s), sales representative(s), agent(s) or individual consultant(s) of the Company and/or of its parent, or its other subsidiary,
affiliated or related companies (other than Philip E. Bruno of McKinsey & Company) to terminate their employment, representation or other association with the Company and/or its parent or its other subsidiary, affiliated or related
companies. 
 (ix)    You will keep in strict confidence, and will not, directly or indirectly, at any time after the
Execution Date, disclose, furnish, disseminate, make available or use any trade secrets or confidential business and technical information of the Company or its customers or vendors, including without limitation as to when or how you may have
acquired such information. Such confidential information shall include, without limitation, the Company’s unique selling, manufacturing and servicing methods and business techniques, training, service and business manuals, promotional
materials, training courses and other training and instructional materials, vendor and product information, customer and prospective customer lists, other customer and prospective customer information and other business information. You specifically
acknowledge that all such confidential information, whether reduced to writing, maintained on any form of electronic media, or maintained in your mind or memory and whether compiled by the Company, and/or Executive, derives independent economic
value from not being readily known to or ascertainable by proper means by others who can obtain economic value from its disclosure or use, that reasonable efforts have been made by the Company to maintain the secrecy of such information, that such
information is the sole property of the Company and that any retention and use of such information by you after the Separation Date shall constitute a misappropriation of the Company’s trade secrets. 

(x)    You agree that on or before the Separation Date, you shall return to the Company, in good condition, all property
of the Company, including without limitation, the originals and all copies of any materials which contain, reflect, summarize, describe, analyze or refer or relate to any items of information listed in Section 8(ix) of this Agreement. In the
event that such items are not so returned, the Company will have the right to charge you for all reasonable damages, costs, attorneys’ fees and other expenses incurred in searching for, taking, removing and/or recovering such property. 

(xi)    You reaffirm that per Section 7(k) of the Employment Agreement, you assigned and agreed to assign to the
Company, its successors, assigns or nominees, all of your rights to any discoveries, inventions and improvements, whether patentable or not, made, conceived or suggested, either solely or jointly with others, by you while in the Company’s
employ, whether in the course of your employment with the use of the Company’s time, material or facilities or that is in any way within or related to the existing or contemplated scope of the Company’s business. Any discovery, invention
or improvement relating to any subject matter with which the Company was concerned during your employment and made, conceived or suggested by you, either solely or jointly with others, within one (1) year following the

  
 7 

 
Separation Date shall be irrebuttably presumed to have been so made, conceived or suggested in the course of such employment with the use of the Company’s time, materials or facilities. Upon
request by the Company with respect to any such discoveries, inventions or improvements, you will execute and deliver to the Company, at any time, all appropriate documents for use in applying for, obtaining and maintaining such domestic and foreign
patents as the Company may desire, and all proper assignments therefor, when so requested, at the expense of the Company, but without further or additional consideration. 

(xii)    You acknowledge that, to the extent permitted by law, all work papers, reports, documentation, drawings,
photographs, negatives, tapes and masters therefor, prototypes and other materials (“Items”), including without limitation, any and all such items generated and maintained on any form of electronic media, generated by you during
your employment with the Company shall be considered a “work made for hire” and that ownership of any and all copyrights in any and all such items shall belong to the Company. The Item will recognize the Company as the copyright owner,
will contain all proper copyright notices, e.g., “(creation date) [Company Name], All Rights Reserved,” and will be in condition to be registered or otherwise placed in compliance with registration or other statutory requirements
throughout the world. 
 (xiii)    During the Transition Period and for one (1) year after the Separation Date,
you will communicate the contents of this Agreement governing noncompetition and non-solicitation provisions to any person, firm, association, partnership, corporation or other entity which you intend to be
employed by, associated with, or represent. 
 (xiv)    You acknowledge and agree that the remedy at law available to
the Company for breach of any of your obligations under this Agreement would be inadequate. You therefore agree that, in addition to any other rights or remedies that the Company may have at law or in equity, temporary and permanent injunctive
relief may be granted in any proceeding which may be brought to enforce any provision contained in Section 8 of this Agreement or Section 7 of the Employment Agreement, without the necessity of proof of actual damage. 

(xv)    You acknowledge that your obligations under this Section 8 and Section 7 of the Employment Agreement
are reasonable in the context of the nature of the Company’s business and the competitive injuries likely to be sustained by the Company if you were to violate such obligations. You further acknowledge that this Agreement is made in
consideration of, and is adequately supported by the agreement of the Company to perform its obligations under this Agreement and by other consideration, which you acknowledge constitutes good, valuable and sufficient consideration. 

b.    In addition, you agree and covenant that you shall not, at any time during the Transition Period and for two
(2) years after the Separation Date, make, publish, or communicate to any person or entity or in any public forum any defamatory, maliciously false, or disparaging remarks, comments, or statements concerning the Company, its Affiliates or their
businesses, or any of their employees, officers, or directors and their existing and prospective customers, suppliers, investors, and other associated third parties, now or in the future, provided, that any remarks, comments or other
statements made, directly or indirectly, by you to a national securities exchange, governmental agency, regulatory authority or self-regulatory organization or 

  
 8 

 
as otherwise required by applicable law about or related to the Company, its Affiliates or their businesses, or any of their employees, officers, or directors and their existing and prospective
customers, suppliers, investors, and other associated third parties which you reasonably believe to be truthful and for which you have a basis in fact for making shall not constitute a violation of this Section 8(b). Likewise, the Company shall
instruct members of the Board and the Company’s senior executives to not, at any time during the Transition Period and for two (2) years after the Separation Date, make, publish, or communicate to any person or entity or in any public
forum any defamatory, maliciously false, or disparaging remarks, comments or statements concerning you or your reputation, provided, that any remarks, comments or other statements made, directly or indirectly, by or on behalf of the Company
or any of its present or former officers, directors, employees or other agents or representatives (each a “Company Representative”) to a national securities exchange, governmental agency, regulatory authority or self-regulatory
organization or as otherwise required by applicable law about or related to you or your reputation which the applicable Company Representative reasonably believes to be truthful and for which such Company Representative has a basis in fact for
making shall not constitute a violation of this Section 8(b). 
 9.    COOPERATION. You agree that you will
cooperate with the Company, during or after the Transition Period, including executing documents and providing requested information, as may reasonably be required to give effect to the provisions of this Agreement or for the Company to comply with
applicable securities laws, and in connection with any litigation or other proceedings in which the Company or any of its Affiliates may from time to time be involved and which is related or otherwise relevant to your service to the Company or its
Affiliates. 
 10.    REPRESENTATIONS AND ACKNOWLEDGMENTS. You make the following representations and
acknowledgments, each of which is an important consideration to the Company’s willingness to enter into this Agreement: 

a.    You represent and acknowledge that you have properly been paid for all hours worked for the Company and neither the
Company nor any other Company Released Party owes you any wages, commissions, bonuses, sick pay, personal leave pay, severance pay, vacation pay or other compensation, benefits or payments or form of remuneration of any kind or nature, other than
that specifically provided for in this Agreement. 
 b.    You acknowledge that the Company is not entering into this
Agreement because it believes that you have any cognizable legal claim against any of the Company Released Parties. If you elect not to sign this Agreement, the fact that this Agreement was offered will not be understood as an indication that any of
the Company Released Parties believed that you were treated unlawfully in any respect. 
 c.    You acknowledge that you
have not filed any claims, complaints, or actions of any kind against the Company with any court of law, or local, state, or federal government or agency. 

  
 9 

 11.    PERMITTED DISCLOSURES. You are hereby provided notice that
under the Defend Trade Secrets Act of 2016 (“DTSA”): (a) no individual will be held criminally or civilly liable under federal or state trade secrets law for the disclosure of a trade secret (as defined in the Economic Espionage
Act) that (i) is made in confidence to a federal, state or local government official, either directly or indirectly, or to an attorney, and made solely for the purpose of reporting or investigating a suspected violation of law, or (ii) is
made in a complaint or other document filed in a lawsuit or other proceeding, if such filing is made under seal so that it is not made public; and (b) an individual who pursues a lawsuit for retaliation by an employer for reporting a suspected
violation of the law may disclose the trade secret to such individual’s attorney and use the trade secret information in the court proceeding, if the individual files any document containing the trade secret under seal and does not disclose the
trade secret, except as permitted by court order. Nothing in this Agreement is intended to conflict with the DTSA or create liability for disclosures of trade secrets that are expressly allowed by such section. Further, it shall not be a violation
of this Agreement for you to (i) provide testimony or access to confidential information in response to a valid subpoena, court order, regulatory request, or other legal process; provided, however, before making any such
disclosure, other than to any governmental agency or regulatory authority or any self-regulatory organization, you shall (unless legally prohibited from doing so) give the Company written notice of your intended disclosure and afford the Company a
reasonable opportunity to protect the Company’s interests, or (ii) voluntarily communicate with, or voluntarily participate in, any investigation or proceeding that may be conducted by, any governmental agency, regulatory authority or
self-regulatory organization concerning possible violations of law, including providing documents or other information in that connection to any governmental agency, regulatory authority or self-regulatory organization, in each case without notice
to the Company or any other Company Released Party. Notwithstanding any other provision in this Agreement, it will not be a breach of any confidentiality provisions referenced in this Agreement for either Party to give truthful testimony and
evidence, or otherwise defend itself, in response to a subpoena or other process of law or in connection with any court or arbitration proceeding or for either Party to exercise protected rights, to the extent that such rights cannot be waived by
agreement or from complying with any applicable law or regulation or a valid order of a court of competent jurisdiction or an authorized government agency, provided that such compliance does not exceed that required by the law, regulation or order.

 12.    CODE SECTION 409A COMPLIANCE. 

a.    This Agreement is intended to comply with, or be exempt from, the provisions of Section 409A of the Internal
Revenue Code of 1986, as amended (the “Code”) so that the income inclusion provisions of said Section 409A do not apply to Executive, and the Company and you accordingly agree to such amendments to the Agreement as may be
necessary or appropriate to reform the provisions of the Agreement to comply with the applicable requirements of Section 409A of the Code and the regulations and Treasury guidance thereunder to prevent any of the benefits provided by this
Agreement from being includible in your gross income before being paid pursuant to this Agreement or otherwise subject to additional income taxes and interest penalties under Section 409A of the Code. 

b.    Notwithstanding any provision to the contrary in this Agreement, no payment or distribution under this Agreement
that constitutes an item of nonqualified deferred compensation (within the meaning of Section 409A of the Code), and becomes payable by reason of your termination of employment will be made to you unless your termination of

  
 10 

 
employment constitutes a separation from service (within the meaning of Section 409A of the Code). For purposes of this Agreement, each amount to be paid or benefit to be provided shall be
construed as a separate identified payment for purposes of Section 409A of the Code. To the extent that any reimbursable expenses hereunder are deemed to constitute compensation to you, such expenses shall be paid or reimbursed promptly, but
not later than by December 31 of the year following the year in which such expenses were incurred. The amount of such expenses eligible for reimbursement in one calendar year shall not affect the amount of expenses eligible for reimbursement in
any other calendar year, and your right to reimbursement of any such expenses shall not be subject to liquidation or exchange for any other benefit. 

c.    Notwithstanding anything to the contrary in this Agreement, any payment to be made to you upon your separation from
service (within the meaning of Section 409A of the Code) which constitutes nonqualified deferred compensation (within the meaning of Section 409A of the Code), will not be made to you until the earliest to occur of: (i) the first day
of the seventh month following the date of your separation from service; or (ii) your death. The foregoing provisions which delay the payment date of certain nonqualified deferred compensation shall only apply if you are a “specified
employee” (within the meaning of Section 409A of the Code) as determined by the Company under the methodology established by the Company at the time of your separation from service and only to the extent necessary to avoid additional
income taxes or interest penalties under Section 409A of the Code. 
 13.    REASONABLE ATTORNEYS’ FEES AND
COSTS. The Company will reimburse you for reasonable attorneys’ fees and costs, up to a maximum of $28,835, that you incur in direct connection with the negotiation of this Agreement. 

14.    GOVERNING LAW. This Agreement will be governed by and construed in accordance with the laws of the State of
Nebraska without giving effect to any principles of conflict of laws that would lead to the application of the laws of another jurisdiction. 

15.    SUCCESSORS AND ASSIGNS. You agree that this Agreement (in whole or in part) will be binding upon, and pass
to the benefit of, the successors and assigns of the Company. You may not assign this agreement in whole or in part. Any purported assignment by you shall be null and void from the initial date of the purported assignment. 

16.    AMENDMENTS. This Agreement may not be amended or modified other than by a written instrument signed by an
authorized representative of both Parties. 
 17.    COUNTERPARTS. This Agreement may be executed in two
(2) or more counterparts, each of which shall be deemed an original, but all of which shall constitute one and the same instrument. Facsimile and .pdf signatures will suffice as original signatures. 

  
 11 

 18.    NOTICES. Any notice provided for in this Agreement shall
be in writing and shall be either personally delivered, sent by reputable overnight carrier or mailed by first class mail, return receipt requested, to the recipient at the address below indicated: 

Notices to Executive: 

Philip G. Heasley 
 3271 Green
Dolphin Lane 
 Naples, FL 34102 

with a copy to: 
 Christopher P.
Sullivan, Esq. 
 Robins Kaplan LLP 

800 Boylston Street Suite 2500 

Boston, MA 02199 

Notices to the Company: 

ACI Worldwide, Inc. 
 6060
Coventry Drive 
 Elkhorn, NE 68022 

Attn: General Counsel 
 or such other address or
to the attention of such other person as the recipient party shall have specified by prior written notice to the sending party. Any notice under this Agreement will be deemed to have been given when so delivered, sent or mailed. 

19.    SEVERABILITY. If any provision of this Agreement is invalid, illegal or unenforceable in any respect, such
provision will be enforced to the maximum extent possible, given the fundamental intentions of the Parties when entering into this Agreement. To the extent such provision cannot be so enforced, it will be stricken from this Agreement and the
remainder of this Agreement will be enforced as if such invalid, illegal or unenforceable provision had never been contained in this Agreement. 

20.    ENTIRE AGREEMENT.    Except as otherwise provided herein, this Agreement, together with
Exhibit A and Exhibit B, sets forth the entire agreement and understanding of the Parties relating to the subject matter hereof and supersedes all prior discussions, agreements, and understandings of every kind and nature between the
Parties hereto (including the Employment Agreement and the Change in Control Employment Agreement between you and the Company, dated July 1, 2016), and neither Party shall be bound by any term or condition other than as expressly set forth or
provided for in this Agreement; provided, that the Indemnification Agreement shall remain in effect following the Separation Date subject to its terms and conditions. For clarity, the Parties acknowledge and agree that except as otherwise
provided on the terms of the documents, you shall have no post-employment termination rights under, and shall not be entitled to any post-employment termination benefits following the Separation Date under or otherwise pursuant to: the Employment
Agreement; any Company bonus plan; the Company’s health plans, including medical, dental and vision insurance plans other than pursuant to timely elected continuation coverage under COBRA; the Company’s 401(k) Plan; the Company’s
insurance plans; and any and all other plans, policies, programs, agreements and arrangements provided for by the Company. 
 [Signature
page follows.] 

  
 12 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the last date set forth
below. 
  

					
	ACI WORLDWIDE, INC.	 	PHILIP G. HEASLEY
			
	By:	 	 /s/ David A. Poe
	 	 /s/ Philip G. Heasley

	Name:	 	David A. Poe	 	
	Title:	 	Chairman	 	
		
	Date: November 5, 2019	 	Date: November 5, 2019

 [Signature Page to Retirement and General Release Agreement] 

 Exhibit A 

Consulting Agreement 

THIS CONSULTING AGREEMENT (the “Agreement”) is entered into as of January 1, 2020 (the “Effective
Date”) by and between ACI Worldwide, Inc., a Delaware corporation (the “Company”), and Philip G. Heasley (“Consultant”) (together, the “Parties”). 

1.    Retention as a Consultant. The Company hereby retains Consultant to serve as an independent consultant to the
Company, on the terms and conditions set forth in this Agreement. 
 2.    Consulting Period. The term of this
Agreement shall commence on the Effective Date and shall terminate on March 31, 2020 (the “Consulting Period”). 

3.    Consulting Services. During the Consulting Period, Consultant will be reasonably available to consult and
cooperate with, answer questions from and provide advice and counseling to, the Company with respect to matters as requested by the Company on an as-needed basis (the “Consulting Services”).

 4.    Independent Contractor Status. The Parties acknowledge and agree that Consultant shall serve as an
independent contractor and not as an employee of the Company. The Parties hereby covenant with one another to treat the engagement of Consultant as that of an independent contractor, and not that of an employee of the Company, for all purposes
including, but not limited to, (a) U.S. and non-U.S. Federal, state and local income, business and employment taxes in any jurisdiction, (b) statutory and fringe benefits and (c) insurance.
Consultant agrees that he is not, and will not claim or represent him to be, an employee or agent of the Company, that Consultant has no authority to enter into any contracts or agreements on behalf of the Company or to otherwise bind the Company in
any manner, and that Consultant will not represent to any person or entity that he/it has any such authority. The Company will not be responsible for withholding or paying any income, payroll, Social Security, or other federal, state or local taxes,
making any insurance contributions, including for unemployment or disability, or obtaining workers’ compensation insurance with respect to the Consulting Services rendered hereunder. Consultant acknowledges and agrees that, during the
Consulting Period, Consultant shall not be eligible to participate in, and waives any claims he may have to, any type of benefits offered to employees of the Company or any of its Affiliates (other than those to which he might be entitled as a
former employee of the Company). 
 5.    Consulting Fee and Related Matters. In exchange for the Consulting
Services and Consultant’s continued compliance with the provisions of this Agreement, during the Consulting Period, the Company shall pay Consultant a consulting fee in an aggregate amount equal to $180,000, payable in substantially equal bi-monthly installments on the Company’s regularly scheduled payroll dates. During the Consulting Period, Consultant shall be reimbursed, upon receipt by the Company of suitable documentation, for reasonable
and necessary travel or other out-of-pocket expenses incurred with prior, written approval by the Company’s Chief Financial Officer in consultation with a Board
member and subject to the Company’s travel reimbursement policy as in effect from time to time; provided, that any such reasonable and necessary travel expected to occur during the Consulting Period shall be subject to pre-approval no later than December 31, 2019. 

  
 A-1 

 6.    Taxes. Consultant agrees and understands that Consultant
will fully assume any and all tax obligations on any payment or consideration paid to Consultant pursuant to this Agreement, and that Consultant shall be exclusively responsible for the reporting, withholding and payment of any and all Federal,
state and local income, business or self-employment taxes in any jurisdiction which may be determined to be due as a result of any payment pursuant to this Agreement. The Company makes no representations concerning the tax consequences of the
consulting fee paid pursuant to this Agreement. Consultant shall indemnify, defend, and hold harmless the Company, its officers, directors, employees, and agents, and its successors, heirs, and assigns, from and against any and all claims, damages
and losses (including interest, penalties and defense costs) related to Consultant’s reporting, payment or non-payment of taxes with respect to the Consulting Services. 

7.    CONTINUING OBLIGATIONS AND COVENANTS. 

a.    Consultant hereby acknowledges that Consultant will continue to be bound by the surviving terms of that certain
amended and restated employment agreement between Consultant and the Company, dated January 7, 2016 (the “Employment Agreement”), including the terms in Section 8 therein (Competitive Activity; Confidentiality;
Nonsolicitation), and as described in Section 8 of that certain retirement and general release agreement entered into as of November 7, 2019 by and between the Company and Consultant (the “Retirement and General Release
Agreement”). 
 b.    Consultant is hereby provided notice that under the Defend Trade Secrets Act of 2016
(“DTSA”): (a) no individual will be held criminally or civilly liable under federal or state trade secrets law for the disclosure of a trade secret (as defined in the Economic Espionage Act) that (i) is made in confidence to a
federal, state or local government official, either directly or indirectly, or to an attorney, and made solely for the purpose of reporting or investigating a suspected violation of law, or (ii) is made in a complaint or other document filed in
a lawsuit or other proceeding, if such filing is made under seal so that it is not made public; and (b) an individual who pursues a lawsuit for retaliation by an employer for reporting a suspected violation of the law may disclose the trade
secret to such individual’s attorney and use the trade secret information in the court proceeding, if the individual files any document containing the trade secret under seal and does not disclose the trade secret, except as permitted by court
order. Nothing in this Agreement is intended to conflict with the DTSA or create liability for disclosures of trade secrets that are expressly allowed by such section. Further, it shall not be a violation of this Agreement for Consultant to
(i) provide testimony or access to confidential information in response to a valid subpoena, court order, regulatory request, or other legal process; provided, however, before making any such disclosure, other than to any
governmental agency or regulatory authority or any self-regulatory organization, Consultant shall (unless legally prohibited from doing so) give the Company written notice of Consultant’s intended disclosure and afford the Company a reasonable
opportunity to protect the Company’s interests, or (ii) voluntarily communicate with, or voluntarily participate in, any investigation or proceeding that may be conducted by, any governmental agency, regulatory authority or self-regulatory
organization concerning possible violations of law, including providing documents or 

  
 A-2 

 
other information in that connection to any governmental agency, regulatory authority or self-regulatory organization, in each case without notice to the Company or any other Company Released
Party. Notwithstanding any other provision in this Agreement, it will not be a breach of any confidentiality provisions referenced in this Agreement for either Party to give truthful testimony and evidence, or otherwise defend itself, in response to
a subpoena or other process of law or in connection with any court or arbitration proceeding or for either Party to exercise protected rights, to the extent that such rights cannot be waived by agreement or from complying with any applicable law or
regulation or a valid order of a court of competent jurisdiction or an authorized government agency, provided that such compliance does not exceed that required by the law, regulation or order. 

c.    Consultant hereby acknowledges and agrees that any communication by Consultant with the Company’s investors or
other third parties during the Consulting Period shall be consistent with any Company communications protocol established by the Board regarding the same subject matter. 

8.    CODE SECTION 409A COMPLIANCE. 

a.    This Agreement is intended to comply with, or be exempt from, the provisions of Section 409A of the Internal
Revenue Code of 1986, as amended (the “Code”) so that the income inclusion provisions of said Section 409A do not apply to Consultant, and the Company and Consultant accordingly agree to such amendments to the Agreement as may
be necessary or appropriate to reform the provisions of the Agreement to comply with the applicable requirements of Section 409A of the Code and the regulations and Treasury guidance thereunder to prevent any of the benefits provided by this
Agreement from being includible in Consultant’s gross income before being paid pursuant to this Agreement or otherwise subject to additional income taxes and interest penalties under Section 409A of the Code. 

b.    Notwithstanding any provision to the contrary in this Agreement, no payment or distribution under this Agreement
that constitutes an item of nonqualified deferred compensation (within the meaning of Section 409A of the Code), and becomes payable by reason of Consultant’s termination will be made to Consultant unless Consultant’s termination
constitutes a separation from service (within the meaning of Section 409A of the Code). For purposes of this Agreement, each amount to be paid or benefit to be provided shall be construed as a separate identified payment for purposes of
Section 409A of the Code. To the extent that any reimbursable expenses hereunder are deemed to constitute compensation to Consultant, such expenses shall be paid or reimbursed promptly, but not later than by December 31 of the year
following the year in which such expenses were incurred. The amount of such expenses eligible for reimbursement in one calendar year shall not affect the amount of expenses eligible for reimbursement in any other calendar year, and Consultant’s
right to reimbursement of any such expenses shall not be subject to liquidation or exchange for any other benefit. 

c.    Notwithstanding anything to the contrary in this Agreement, any payment to be made to Consultant upon
Consultant’s separation from service (within the meaning of Section 409A of the Code) which constitutes nonqualified deferred compensation (within the meaning of Section 409A of the Code), will not be made to Consultant until the
earliest to occur of: (i) the first day of the seventh month following the date of Consultant’s separation from 

  
 A-3 

 
service; or (ii) Consultant’s death. The foregoing provisions which delay the payment date of certain nonqualified deferred compensation shall only apply if Consultant is a
“specified employee” (within the meaning of Section 409A of the Code) as determined by the Company under the methodology established by the Company at the time of Consultant’s separation from service and only to the extent
necessary to avoid additional income taxes or interest penalties under Section 409A of the Code. 

9.    GOVERNING LAW. This Agreement will be governed by and construed in accordance with the laws of the State of
Nebraska without giving effect to any principles of conflict of laws that would lead to the application of the laws of another jurisdiction. 

10.    SUCCESSORS AND ASSIGNS. Consultant agrees that this Agreement (in whole or in part) will be binding upon,
and pass to the benefit of, the successors and assigns of the Company. Consultant may not assign this agreement in whole or in part. Any purported assignment by Consultant shall be null and void from the initial date of the purported assignment.

 11.    AMENDMENTS. This Agreement may not be amended or modified other than by a written instrument signed by
an authorized representative of both Parties. 
 12.    COUNTERPARTS. This Agreement may be executed in two
(2) or more counterparts, each of which shall be deemed an original, but all of which shall constitute one and the same instrument. Facsimile and .pdf signatures will suffice as original signatures. 

13.    NOTICES. Any notice provided for in this Agreement shall be in writing and shall be either personally
delivered, sent by reputable overnight carrier or mailed by first class mail, return receipt requested, to the recipient at the address below indicated: 

Notices to Consultant: 

Philip G. Heasley 
 3271 Green
Dolphin Lane 
 Naples, FL 34102 

with a copy to: 
 Christopher P.
Sullivan, Esq. 
 Robins Kaplan LLP 

800 Boylston Street Suite 2500 

Boston, MA 02199 

Notices to the Company: 

ACI Worldwide, Inc. 
 3520 Kraft
Road 
 Naples, FL 34105 

Attn: General Counsel 

  
 A-4 

 or such other address or to the attention of such other person as the recipient party shall have specified
by prior written notice to the sending party. Any notice under this Agreement will be deemed to have been given when so delivered, sent or mailed. 

14.    SEVERABILITY. If any provision of this Agreement is invalid, illegal or unenforceable in any respect, such
provision will be enforced to the maximum extent possible, given the fundamental intentions of the Parties when entering into this Agreement. To the extent such provision cannot be so enforced, it will be stricken from this Agreement and the
remainder of this Agreement will be enforced as if such invalid, illegal or unenforceable provision had never been contained in this Agreement. 

15.    ENTIRE AGREEMENT. Except as otherwise provided herein, this Agreement, together with the Retirement and
General Release Agreement, and Exhibit B, sets forth the entire agreement and understanding of the Parties relating to the subject matter hereof and supersedes all prior discussions, agreements, and understandings of every kind and nature
between the Parties hereto (including the Employment Agreement and the Change in Control Employment Agreement between you and the Company, dated July 1, 2016), and neither Party shall be bound by any term or condition other than as expressly
set forth or provided for in this Agreement; provided, that the indemnification agreement between you and the Company, dated March 11, 2009 shall remain in effect following the Effective Date subject to its terms and conditions. For
clarity, the Parties acknowledge and agree that except as otherwise provided on the terms of the documents, Consultant shall have no post-employment termination rights under, and shall not be entitled to any post-employment termination benefits
following the Separation Date under or otherwise pursuant to: the Employment Agreement; any Company bonus plan; the Company’s health plans, including medical, dental and vision insurance plans other than pursuant to timely elected continuation
coverage under COBRA; the Company’s 401(k) Plan; the Company’s insurance plans; and any and all other plans, policies, programs, agreements and arrangements provided for by the Company. 

[Signatures appear on the following page] 

  
 A-5 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the last date set forth
below. 
  

					
	ACI WORLDWIDE, INC.	 	PHILIP G. HEASLEY
			
	By:	 	 /s/ David A. Poe
	 	 /s/ Philip G. Heasley

	Name:	 	David A. Poe	 	
	Title:	 	Chairman	 	
		
	Date: November 5, 2019	 	Date: November 5, 2019

 [Signature page to Consulting Agreement] 

  
 A-6 

 Exhibit B 

Supplemental Release of Claims 

1.    Release. 

a.    For good and valuable consideration, including the Company’s provision of a certain payment to you in accordance
with Section 3(b) of the Retirement and General Release Agreement, dated November 7, 2019 (the “Retirement Agreement”), you hereby forever release and discharge the Company and its parents, and their Affiliates,
successors, and assigns, as well as each of their past and present officers, directors, employees, agents, attorneys, and stockholders (collectively, the “Company Released Parties”), from any and all claims, charges, complaints,
liens, demands, causes of action, obligations, damages, and liabilities, known or unknown, suspected or unsuspected, that you had, now have, or may hereafter claim to have against the Company Released Parties arising out of, or
relating in any way to, (i) any act or omission from the beginning of time to the date you sign this Agreement including, without limitation, any and all claims or causes of action for wrongful termination, breach of an express or implied
contract, breach of the covenant of good faith and fair dealing, breach of fiduciary duty, fraud, misrepresentation, defamation, slander, infliction of emotional distress, disability, loss of future earnings, and any claims under any applicable
state, federal, or local statutes and regulations, including, but not limited to, the Age Discrimination in Employment Act of 1967, as amended by the Older Workers Benefit Protection Act (the “ADEA”), the Civil Rights Act of 1964,
as amended, the Equal Pay Act of 1963, as amended, the Fair Labor Standards Act, as amended, the Americans with Disabilities Act of 1990, as amended, the Rehabilitation Act of 1973, as amended, the Employee Retirement Income Security Act of 1974, as
amended, the Worker Adjustment and Retraining Notification Act, as amended, the Fair Credit Reporting Act, Section 806 of the Sarbanes-Oxley Act, the Dodd-Frank Act, the Family and Medical Leave Act, as amended, and the Nebraska Fair Employment
Practice Act (Neb. Rev. St. §§ 48-1101 to 48-1125); the Nebraska Age Discrimination in Employment Act (Neb. Rev. St. §§ 48-1001 to 48-1010); the Nebraska Wage Payment and Collection Act (Neb. Rev. St. §§ 48-1228 to
48-1234); Nebraska’s privacy laws (Neb. Rev. St. §§ 20-201 to 20-211 and
25-840.01); Nebraska’s drug testing laws (Neb. Rev. St. §§ 48-1901 to 48-1910); Nebraska’s military leave
laws (Neb. Rev. St. §§ 55-160 to 55-166 and 55-501 to 55-507); Nebraska laws
related to equal pay (Neb. Rev. St. §§ 48-1219 to 48-1227.01); and Nebraska leave laws (Neb. Rev. St. §§
25-1640, 32-922, 48-234, 32-241, and 35-1403 to 35-1405), (ii) your employment with, including during the Transition Period, or your termination of employment from the Company or (iii) any arrangement or understanding, including the Employment Agreement,
between you and the Company; provided, however, that this Release does not waive, release or otherwise discharge (A) any claim or cause of action arising from a breach by the Company of this Agreement or that cannot legally be
waived, including, but not limited to, any claim for unpaid wages, workers’ compensation benefits, unemployment benefits or (B) any rights to indemnification under that certain indemnification agreement between you and the Company, dated
March 11, 2009 or applicable law (the “Excluded Claims”).  

  
 B-1 

 b.    You further acknowledge and agree that, except with respect to the
Excluded Claims, the Company Released Parties have fully satisfied any and all obligations whatsoever owed to you arising out of your employment with the Company or any other Company Released Party, and that no further payments or benefits are owed
to you by the Company or any other Company Party. 
 2.    Review and Revocation Period. 

a.    You acknowledge that (i) the Company and/or its successor has advised you to consult with an attorney of your
own choosing before signing this Supplemental Release, (ii) you have been given the opportunity to seek the advice of counsel, (iii) you have carefully read and fully understand all of the provisions of this Supplemental Release,
(iv) the release provided herein specifically applies to any rights or claims you may have against the Company Released Parties pursuant to the ADEA, (v) you are entering into this Supplemental Release knowingly, freely and voluntarily in
exchange for good and valuable consideration to which you are not otherwise entitled, including the payments and benefits set forth in Section 4(b) of the Retirement Agreement, and (vi) you have the full power, capacity and authority to
enter into this Supplemental Release. 
 b.    You understand and agree that you have
twenty-one (21) days following your receipt of this Supplemental Release to review this Supplemental Release and its terms and to reflect upon them and consider whether you want to sign it, although you
may sign it sooner. You understand and agree that you may accept this Supplemental Release by signing and returning it within the applicable time frame to ACI Worldwide, Inc., 3520 Kraft Road, Naples, FL 34105, Attn: General Counsel or via email to
dennis.byrnes@aciworldwide.com. 
 c.    Notwithstanding the initial effectiveness of this Supplemental Release. you may
revoke the execution and delivery (and therefore the effectiveness) of this Supplemental Release within the seven (7)-day period beginning on the date you deliver the
re-execution to the Company (such seven (7)-day period being refined to herein as the “Release Revocation Period”). To be effective, such revocation mist be in
writing signed by you and must be delivered to Company by 11:59 p.m., Eastern Standard time, on the last day of the Release Revocation Period. 

d.    In the event of such revocation by you, this Supplemental Release shall be of no force or effect, and you shall not
have any rights and the Company shall not have any obligations under Section 4(b) of the Retirement Agreement. Provided that you do not revoke your consent to this Supplemental Release within the Release Revocation Period, this Supplemental
Release shall become effective on the eighth (8th) calendar day after the date upon which you execute this Supplemental Release (the “Supplemental Release Effective Date”). 

 

	
	  

	Philip Heasley
	
	Date:                     

  
 B-2

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