Document:

Exhibit
10.6

 

EXECUTION
VERSION

 

AGREEMENT

 

This
Agreement (the “Agreement”), dated as of August 13, 2020, is made and entered into by and among TSR, Inc. (“TSRI”),
on the one hand, and Zeff Capital, L.P. (“Zeff Capital”), Zeff Holding Company, LLC (“Zeff Holding”)
and Daniel Zeff (which, together with Zeff Capital and Zeff Holding shall be referred to collectively as the “Zeff Parties”),
on the other hand. TSRI and the Zeff Parties are collectively referred to herein as the “Parties” and each
as a “Party.”

 

RECITALS

 

WHEREAS,
in 2018 and 2019 the Zeff Parties incurred various costs and expenses, including, without limitation, attorneys’ fees, fees
of its proxy solicitor, and related fees (the “Proxy Costs”), in conjunction with proxy solicitations related
to TSRI’s annual stockholders’ meetings (the “Proxy Contest”);

 

WHEREAS,
the Zeff Parties incurred various costs and expenses, including, without limitation, attorneys’ fees (the “Settlement
Costs”) in connection with the negotiation, execution and enforcement of that certain Settlement and Release Agreement,
dated as of August 30, 2019, by and among TSRI, the Zeff Parties and certain other parties (the “Original Settlement”);

 

WHEREAS,
the Zeff Parties also incurred various costs and expenses, including, without limitation, attorneys’ fees and related fees
(the “Paskowitz Costs”), in conjunction with: (i) Susan Paskowitz v. James J. Hill, et. al., No. 715541/2018
(Queens County) and (ii) Paskowitz v. Zeff Capital, L.P. et al., 1:19-cv-00167-KPF (S.D.N.Y.) (the “Paskowitz
Actions”);

 

WHEREAS,
the Parties disagree about the meaning and effect of certain provisions of the Original Settlement Agreement; and

 

WHEREAS,
the Parties wish to settle and resolve their disagreement as to the Original Settlement Agreement without admission of fault by
any of them and, as part of that resolution, agree on the reimbursement of the Zeff Parties by TSRI of certain of the Proxy Costs
and the Settlement Costs.

 

NOW,
THEREFORE, in consideration of the mutual promises contained in this Agreement and other good and valuable consideration,
the legal sufficiency of which is hereby acknowledged, each of the Parties, intending to be legally bound, hereby agrees as follows:

 

1. Settlement
Payment:

 

		a.	In
                                         full accord and satisfaction of the Proxy Costs and Settlement Costs, TSRI shall cause
                                         to be paid to the Zeff Parties the total sum of nine hundred thousand dollars (US$900,000)
                                         (the “Settlement Amount”), which shall be paid in three (3) installments
                                         as follows:

 

		i.	Three
                                         hundred thousand dollars (US$300,000) shall be paid by wire transfer of immediately available
                                         funds no later than June 30, 2021 to an account designated in writing by Zeff Capital
                                         at least three (3) business days prior to such installment payment date.

 

     

     

    

 

		ii.	Three
                                         hundred thousand dollars (US$300,000) shall be paid by wire transfer of immediately available
                                         funds no later than June 30, 2022 to an account designated in writing by Zeff Capital
                                         at least three (3) business days prior to such installment payment date.

 

		iii.	Three
                                         hundred thousand dollars (US$300,000) shall be paid by wire transfer of immediately available
                                         funds no later than June 30, 2022 to an account designated in writing by Zeff Capital
                                         at least three (3) business days prior to such installment payment date, it being understood
                                         that TSRI’s board of directors (the “Board”) may, in good faith,
                                         elect to pay this amount in the form of shares of TSRI’s common stock having a
                                         value equal to three hundred thousand dollars (US$300,000) (with any fractional shares
                                         rounded up to the nearest whole share) based on the lesser of (1) the volume-weighted
                                         average price (as reported by Bloomberg L.P. or, if not reported therein, in another
                                         authoritative source mutually selected by the Parties) for the thirty (30) day period
                                         immediately preceding the earlier of (x) the date of the Board’s decision to make
                                         the third installment payment in stock and (y) June 30, 2022; or (2) $7.00 per share
                                         of TSRI’s common stock. If the Board elects to make this third installment payment
                                         in the form of shares of TSRI’s common stock, then TSRI will take all actions necessary
                                         to cause such shares to be registered under the Securities Act of 1933 within 60 days
                                         of issuance.

 

Except
as provided in subpart (b) below, in no event shall TSRI be obligated to pay any interest on the Settlement Amount.

 

		b.	Notwithstanding
                                         anything to the contrary set forth in subpart (a) above, if any installment payment of
                                         the Settlement Amount would cause or result in a default under or breach of any covenant
                                         in TSRI’s debt agreements with its senior lenders (including, without limitation,
                                         Access Capital) that is in effect on the date of this Agreement, then TSRI shall have
                                         the option to defer the payment of such installment payment until such time as the payment
                                         thereof would not cause a default or breach under such debt agreements. TSRI will use
                                         its reasonable best efforts to make any such deferred payment as soon as possible (including,
                                         without limitation, by obtaining, at TSRI’s expense, appropriate waivers or consents
                                         under such debt agreements). Any such deferred payment will accrue interest (beginning
                                         on the date of the deferment and ending on the date such deferred payment is actually
                                         paid to the Zeff Parties, calculated on the basis of a 365 day year and the actual number
                                         of days elapsed) at the “base rate” or “prime rate” announced
                                         by Citibank, N.A. on the date that such payment was required to be made, plus 3.75 percent
                                         (3.75%). At any time, the Zeff Parties may convert any such deferred payment (including
                                         the interest accrued thereon) into shares of TSRI’s common stock having a value
                                         equal to such deferred payment (including the interest accrued thereon) (with any fractional
                                         shares rounded up to the nearest whole share) based on the volume-weighted average price
                                         (as reported by Bloomberg L.P. or, if not reported therein, in another authoritative
                                         source mutually selected by the Parties) for the thirty (30) day period immediately preceding
                                         the conversion. If the Zeff Parties elect such conversion, then TSRI will take all actions
                                         necessary to cause the shares of TSRI’s common stock that are issued to be registered
                                         under the Securities Act of 1933 within 60 days of issuance.

 

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2. Release
by Zeff Parties: The Zeff Parties, for and on behalf of themselves and their parents, subsidiaries, affiliates, shareholders,
members, officers, directors, partners, employees, agents, attorneys, and insurers, hereby release and discharge TSRI and its
current directors and executive officers, together with and for the benefit of their agents, attorneys, insurers, heirs, successors
and assigns (collectively, the “TSRI Released Parties”), from and against any and all claims, actions, demands,
petitions, complaints, or causes of action for breaches, violations, losses, or damages of any kind, nature or description, in
law, rule or equity, and whether known or unknown, that have been or could have been asserted relating to the Proxy Contest, the
Original Settlement, the Paskowitz Costs and the Paskowitz Actions; provided, however, that this paragraph 2 does
not release and shall not be construed to release any obligations under this Agreement.

 

3. Release
by TSRI: TSRI, for and on behalf of itself, its parents, subsidiaries, affiliates, shareholders, members, officers, directors,
partners, employees, agents, attorneys, and insurers, hereby releases and discharges the Zeff Parties, together with and for the
benefit of any of their parents, subsidiaries, affiliates, shareholders, members, officers, directors, partners, employees, agents,
attorneys, insurers, successors and assigns (collectively, the “Zeff Released Parties”), from and against any
and all claims, actions, demands, petitions, complaints, or causes of action for breaches, violations, losses, or damages of any
kind, nature or description, in law, rule or equity, and whether known or unknown, that have been or could have been asserted
relating to the Proxy Contest, the Original Settlement, the Paskowitz Costs and the Paskowitz Actions; provided, however,
that this paragraph 3 does not release and shall not be construed to release any obligations under this Agreement.

 

4. Waiver
of Section 1542: Each of the Parties hereby expressly waives any rights afforded to it by Section 1542 of the Civil Code of
the State of California (“Section 1542”), or any other similar statute or provision in any other jurisdiction.
Section 1542 states:

 

A
general release does not extend to claims that the creditor or releasing party does not know or suspect to exist in his or her
favor at the time of executing the release and that, if known to him or her, would have materially affected his or her settlement
with the debtor

 

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5. Entire
Agreement: This Agreement constitutes the entire understanding of the Parties concerning its subject matter and may not be
modified, altered, or reformed except by a writing signed by all Parties. No representations or promises except those set forth
herein have been made to induce any Party to enter into this Agreement.

 

6. Legal
Counsel; Authority: Each of the Parties executing this Agreement represents and warrants that it (i) has had the opportunity
to consider the terms and provisions of this Agreement; (ii) has consulted with legal counsel of its own choosing prior to executing
this Agreement; (iii) has carefully read this Agreement in its entirety and fully understands the significance and legal consequences
of all of its terms and provisions; and (iv) is signing this Agreement voluntarily and of its own free will, and assents to all
the terms and conditions contained herein.

 

7. No
Presumption Against Any Party: No Party shall be deemed to be the drafter of this Agreement for purposes of interpreting any
provision hereof in any judicial proceeding that may arise between or among the Parties. No language in this Agreement shall be
presumptively construed in favor of or against any of the Parties to this Agreement based solely on who drafted such language.

 

8. Severability:
In the event that any portion of this Agreement is deemed by a court of competent jurisdiction to be invalid or unenforceable
for any reason, to the extent permitted by applicable law, such portion shall be deemed severable, and the remainder of the Agreement
will be deemed and remain fully valid and enforceable.

 

9. Choice
of Law: This Agreement and any and all disputes related to or arising out of this Agreement shall be governed by the laws
of the State of Delaware, without regard to any conflicts-of-laws analysis.

 

10. Forum:
The Parties agree that any dispute arising out of or relating to this Agreement shall be brought in the Delaware Court of Chancery
(or, if any such court declines to accept jurisdiction over a particular matter, any state or federal court located in Delaware).
Each Party: (i) expressly and irrevocably consents and submits to the jurisdiction of each state and federal court located in
Delaware (and each appellate court related thereto) in connection with any such dispute; (ii) agrees that each state and federal
court located in Delaware shall be deemed to be a convenient forum; and (iii) agrees not to assert (by way of motion, as a defense
or otherwise), in any legal proceeding commenced in any state or federal court located in Delaware related to this Agreement,
any claim that such Party is not subject personally to the jurisdiction of such court, that such legal proceeding has been brought
in an inconvenient forum, that the venue of such proceeding is improper or that this Agreement or the subject matter of this Agreement
may not be enforced in or by such court. EACH PARTY HEREBY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY RIGHT
IT MAY HAVE TO A TRIAL BY JURY IN RESPECT OF ANY CLAIM, ACTION, SUIT OR PROCEEDING DIRECTLY OR INDIRECTLY ARISING OUT OF, UNDER
OR IN CONNECTION WITH THIS AGREEMENT. EACH PARTY (I) CERTIFIES THAT NO REPRESENTATIVE OF THE OTHER PARTY HAS REPRESENTED, EXPRESSLY
OR OTHERWISE, THAT SUCH OTHER PARTY WOULD NOT, IN THE EVENT OF ANY CLAIM, ACTION, SUIT OR PROCEEDING, SEEK TO ENFORCE THE FOREGOING
WAIVER AND (II) ACKNOWLEDGES THAT IT AND THE OTHER PARTY HAVE BEEN INDUCED TO ENTER INTO THIS AGREEMENT BY, AMONG OTHER THINGS,
THE MUTUAL WAIVERS AND CERTIFICATIONS IN THIS SECTION 10.

 

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11. Costs/Fees:
The Parties agree that all attorneys’ fees, costs, and expenses incurred by the Parties in the preparation of this Agreement
will be borne by the Party incurring the same.

 

12. Execution
in Counterparts: This Agreement may be executed in any number of counterparts, each of which when so executed and delivered
will serve as an original, and the execution and exchange of an electronic or facsimile signed copy of the executed Agreement
shall be binding.

 

13. Representations
and Warranties of TSRI: TSRI represents and warrants to the Zeff Parties as follows:

 

		a.	the
                                         Board approved entering into this Agreement, and TSRI has the corporate power and authority
                                         to execute this Agreement and to bind it thereto;

 

		b.	this
                                         Agreement has been duly and validly authorized, executed and delivered by TSRI, and is
                                         a valid and binding obligation of TSRI, enforceable against TSRI in accordance with its
                                         terms, except as enforcement thereof may be limited by applicable bankruptcy, insolvency,
                                         reorganization, moratorium, fraudulent conveyance or similar laws generally affecting
                                         the rights of creditors and subject to general equity principles;

 

		c.	the
                                         execution, delivery and performance of this Agreement by TSRI does not and will not (i)
                                         violate or conflict with any law, rule, regulation, order, judgment or decree applicable
                                         to TSRI, or (ii) result in any breach or violation of or constitute a default (or an
                                         event which with notice or lapse of time or both could constitute such a breach, violation
                                         or default) under or pursuant to, or result in the loss of a material benefit under,
                                         or give any right of termination, amendment, acceleration or cancellation of, any organizational
                                         document, agreement, contract, commitment, understanding or arrangement to which TSRI
                                         is a party or by which it is bound;

 

		d.	as
                                         of the date of this Agreement, there is no suit, action investigation or proceeding pending
                                         or, to the knowledge of TSRI, threatened against TSRI, that could materially impair the
                                         ability of TSRI to perform its obligations under this Agreement or to consummate the
                                         transactions contemplated by this Agreement to which it is a party; and

 

		e.	no
                                         consent, approval, order authorization, registration or qualification of or with any
                                         governmental or regulatory authority or organization having jurisdiction over TSRI or
                                         any third party is required in connection with the execution, delivery and performance
                                         by TSRI of this Agreement or the consummation by TSRI of any transactions contemplated
                                         hereby to which the TSRI is a party.

 

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14. Representations
and Warranties of Zeff Parties: Each Zeff Party, severally and not jointly, represents and warrants to TSRI each of the following:

 

		a.	such
                                         Zeff Party has the corporate, limited liability company or other power and authority
                                         to execute this Agreement and to bind it thereto;

 

		b.	this
                                         Agreement has been duly authorized, executed and delivered by such Zeff Party, and is
                                         a valid and binding obligation of such Zeff Party, enforceable against such Zeff Party
                                         in accordance with its terms, except as enforcement thereof may be limited by applicable
                                         bankruptcy, insolvency, reorganization, moratorium, fraudulent conveyance or similar
                                         laws generally affecting the rights of creditors and subject to general equity principles;

 

		c.	the
                                         execution, delivery and performance of this Agreement by such Zeff Party does not and
                                         will not (i) violate or conflict with any law, rule, regulation, order, judgment or decree
                                         applicable to such Zeff Party, or (ii) result in any breach or violation of or constitute
                                         a default (or an event which with notice or lapse of time or both could constitute such
                                         a breach, violation or default) under or pursuant to, or result in the loss of a material
                                         benefit under, or give any right of termination, amendment, acceleration or cancellation
                                         of, any organizational document, agreement, contract, commitment, understanding or arrangement
                                         to which such Zeff Party is a party or by which it is bound;

 

		d.	as
                                         of the date of this Agreement, there is no suit, action investigation or proceeding pending
                                         or, to the knowledge of such Zeff Party, threatened against such Zeff Party, that could
                                         materially impair the ability of such Zeff Party to perform its obligations under this
                                         Agreement or to consummate the transactions contemplated by this Agreement to which it
                                         is a party; and

 

		e.	no
                                         consent, approval, order authorization, registration or qualification of or with any
                                         governmental or regulatory authority or organization having jurisdiction over such Zeff
                                         Party is required in connection with the execution, delivery and performance by such
                                         Zeff Party of this Agreement or the consummation by such Zeff Party of any transactions
                                         contemplated hereby to which such Zeff Party is a party.

 

15. Further
Cooperation: The Parties covenant and agree that, without expanding their substantive obligations under this Agreement, they
shall do all acts and execute and obtain all documents, to the full extent necessary or appropriate, to implement and enforce
this Agreement according to its terms.

 

16. Equitable
Relief: Each Party acknowledges and agrees that money damages would not be a sufficient remedy for any breach (or threatened
breach) of this Agreement by it and that, in the event of any breach or threatened breach of this Agreement, (a) the Party seeking
specific performance will be entitled to injunctive and other equitable relief, without proof of actual damages; (b) the Party
against whom specific performance is sought will not plead in defense that there would be an adequate remedy at law; and (c) the
Party against whom specific performance is sought agrees to waive any applicable right or requirement that a bond be posted. Such
remedies will not be the exclusive remedies for a breach of this Agreement, but will be in addition to all other remedies available
at law or in equity.

 

17. Binding
Effect: This Agreement shall be binding upon and/or inure to the benefit of the Parties and their respective heirs, estates,
executors, administrators, personal representatives, successors, corporate parents and assigns. This Agreement is not intended
to and shall not confer any rights or remedies upon any person other than the Parties and their respective successors and permitted
assigns.

 

[SIGNATURES
ON NEXT PAGE]

 

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IN
WITNESS WHEREOF, each of the Parties has executed this Agreement as of the date set forth above.

   

	TSR, Inc.	 	Zeff Capital, L.P.
	 	 	By: Zeff Holding Company, LLC, as
	 	 	general partner
	 	 	 
	By: 	/s/ Bradley Tirpak.	 	By: 	/s/ Daniel Zeff
	Name: Bradley Tirpak	 	Name: Daniel Zeff
	Title: Chairman of the Board	 	Title: Manager
	Date: August 13, 2020	 	 

 

	Zeff Holding Company, LLC	 	Daniel Zeff
	 	 	 
	By: 	/s/ Daniel Zeff	 	/s/ Daniel Zeff
	Name: Daniel Zeff	 	 
	Title: Manager	 	 

 

 

 

7EX-4.2

 Exhibit 4.2 

OFFICER’S CERTIFICATE OF 

AMGEN INC. 
 Dated as of August 17,
2020 
 The undersigned officer of Amgen Inc., a Delaware corporation (the “Company”), certifies, pursuant to resolutions
duly adopted by the Board of Directors of the Company at a meeting duly held on March 4, 2020, and by the Pricing Committee of the Board of Directors of the Company on July 27, 2020, and in accordance with Sections 2.1, 2.2 and 2.3 of the
Indenture, dated as of May 22, 2014 (the “Indenture”; capitalized terms used herein and not otherwise defined shall have the meanings given to them in the Indenture), between the Company, and The Bank of New York Mellon Trust
Company, N.A., as trustee (the “Trustee”), the following matters related to the issuance of the Company’s 2.770% Senior Notes due 2053 (the “2053 Notes”): 

1. Attached hereto as Annex A is a true and correct copy of a specimen note (the “Form of Note”) representing the 2053
Notes. The Form of Note sets forth certain of the terms required to be set forth in this Certificate pursuant to Section 2.2 of the Indenture, and said terms are incorporated herein by reference. The 2053 Notes are a separate series of
Securities under the Indenture. As used herein, the term “Notes” shall include the 2053 Notes and any exchange notes (the “Exchange Securities”) issued in exchange for the 2053 Notes pursuant to the transactions
contemplated by that certain Registration Rights Agreement, dated as of August 17, 2020 (the “Registration Rights Agreement”), by and among the Company and the dealer managers named therein. 

2. The title of the 2053 Notes shall be the “2.770% Senior Notes due 2053.” 

3. The 2053 Notes shall be issued at the initial offering price of 100% of the principal amount. 

4. The Company will initially issue $940,000,000 aggregate principal amount of 2053 Notes (except for Notes authenticated and delivered upon
registration of transfer of, in exchange for, or in lieu of, other Notes pursuant to Sections 2.7, 2.8, 2.11, 3.6 or 9.6 of the Indenture).    The Company may issue additional 2053 Notes from time to time after the date hereof,
and such Notes will be treated as part of the series of Notes for all purposes under the Indenture. 
 5. The 2053 Notes and the Exchange
Securities shall be issued as Global Securities only and will be exchangeable for certificated notes (“Certificated Notes”) only if: 
  

	 	(a)	 DTC (x) notifies the Company that it is unwilling or unable to continue as depository for the Global
Securities or (y) at any time has ceased to be a clearing agency registered under the Exchange Act at a time when it is required to be registered and, in either case, the Company fails to appoint a successor depository registered as a clearing
agency under the Exchange Act within 90 days of notification to the Company or the Company becoming aware of DTC’s ceasing to be so registered, as the case may be; 

 

	 	(b)	 the Company, at its option, notifies the Trustee in writing to the effect that the Company elects to cause the
issuance of the Certificated Notes; or 

  
 1 

	 	(c)	 there has occurred and is continuing an Event of Default with respect to the Notes. 

Certificated Notes delivered in exchange for any Global Security or beneficial interests in Global Securities will be registered in the names,
and issued in any approved denominations, requested by or on behalf of the depository (in accordance with its customary procedures). 
 6.
The Global Securities and the Certificated Notes will bear one of the following restrictive legends unless the legend is not required by applicable law, or as set forth in Item 7 below: 

 

	 	(a)	 144A Global Note Legend. Each Global Note issued under Rule 144A under the Securities Act shall bear a
legend in substantially the following form: 

 “THIS SECURITY HAS NOT BEEN REGISTERED UNDER THE U.S. SECURITIES ACT OF
1933, AS AMENDED (THE “SECURITIES ACT”), OR THE SECURITIES LAWS OF ANY STATE OR OTHER JURISDICTION. NEITHER THIS SECURITY NOR ANY INTEREST OR PARTICIPATION HEREIN MAY BE RESOLD, PLEDGED OR TRANSFERRED IN THE ABSENCE OF SUCH REGISTRATION OR
UNLESS SUCH TRANSACTION IS EXEMPT FROM, OR NOT SUBJECT TO, SUCH REGISTRATION. THE HOLDER HEREOF, BY PURCHASING THIS SECURITY, AGREES ON ITS OWN BEHALF AND ON BEHALF OF ANY INVESTOR ACCOUNT FOR WHICH IT HAS PURCHASED SECURITIES, THAT THIS SECURITY OR
ANY INTEREST OR PARTICIPATION HEREIN MAY BE OFFERED, RESOLD, PLEDGED OR OTHERWISE TRANSFERRED ONLY (I) TO AMGEN INC. (THE “ISSUER”) OR ANY OF ITS SUBSIDIARIES, (II) SO LONG AS THIS SECURITY IS ELIGIBLE FOR RESALE PURSUANT TO RULE
144A UNDER THE SECURITIES ACT (“RULE 144A”), TO A PERSON THE SELLER REASONABLY BELIEVES IS A QUALIFIED INSTITUTIONAL BUYER (AS DEFINED IN RULE 144A) IN ACCORDANCE WITH RULE 144A, (III) IN AN OFFSHORE TRANSACTION TO A NON-U.S. PERSON IN ACCORDANCE WITH RULE 903 OR 904 OF REGULATION S UNDER THE SECURITIES ACT, (IV) PURSUANT TO AN EXEMPTION FROM REGISTRATION PROVIDED BY RULE 144 UNDER THE SECURITIES ACT (IF AVAILABLE), OR
(V) PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT, AND IN EACH OF SUCH CASES IN ACCORDANCE WITH ANY APPLICABLE SECURITIES LAWS OF ANY STATE OF THE UNITED STATES OR OTHER APPLICABLE JURISDICTION. THE HOLDER HEREOF, BY
PURCHASING THIS SECURITY, REPRESENTS AND AGREES THAT IT WILL NOTIFY ANY PURCHASER OF THIS SECURITY FROM IT OF THE RESALE RESTRICTIONS REFERRED TO ABOVE. THE FOREGOING LEGEND MAY BE REMOVED FROM THIS SECURITY ONLY WITH THE CONSENT OF THE
ISSUER.” 
  

	 	(b)	 Regulation S Global Note Legend. Each Global Note issued under Regulation S under the Securities Act
shall bear a legend in substantially the following form: 

 “THIS SECURITY HAS NOT BEEN REGISTERED UNDER THE U.S.
SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR THE SECURITIES LAWS OF ANY STATE OR OTHER JURISDICTION. NEITHER THIS SECURITY NOR ANY INTEREST OR PARTICIPATION HEREIN MAY BE RESOLD, PLEDGED OR TRANSFERRED IN THE ABSENCE OF
SUCH REGISTRATION OR UNLESS SUCH 

  
 2 

 
TRANSACTION IS EXEMPT FROM, OR NOT SUBJECT TO, SUCH REGISTRATION. THE HOLDER HEREOF, BY PURCHASING THIS SECURITY, AGREES ON ITS OWN BEHALF AND ON BEHALF OF ANY INVESTOR ACCOUNT FOR WHICH IT HAS
PURCHASED SECURITIES, THAT THIS SECURITY OR ANY INTEREST OR PARTICIPATION HEREIN MAY BE OFFERED, RESOLD, PLEDGED OR OTHERWISE TRANSFERRED ONLY (I) TO AMGEN INC. (THE “ISSUER”) OR ANY OF ITS SUBSIDIARIES, (II) SO LONG AS THIS
SECURITY IS ELIGIBLE FOR RESALE PURSUANT TO RULE 144A UNDER THE SECURITIES ACT (“RULE 144A”), TO A PERSON THE SELLER REASONABLY BELIEVES IS A QUALIFIED INSTITUTIONAL BUYER (AS DEFINED IN RULE 144A) IN ACCORDANCE WITH RULE 144A,
(III) IN AN OFFSHORE TRANSACTION TO A NON-U.S. PERSON IN ACCORDANCE WITH RULE 903 OR 904 OF REGULATION S UNDER THE SECURITIES ACT, (IV) PURSUANT TO AN EXEMPTION FROM REGISTRATION PROVIDED BY RULE 144
UNDER THE SECURITIES ACT (IF AVAILABLE), OR (V) PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT, AND IN EACH OF SUCH CASES IN ACCORDANCE WITH ANY APPLICABLE SECURITIES LAWS OF ANY STATE OF THE UNITED STATES OR OTHER
APPLICABLE JURISDICTION. THE HOLDER HEREOF, BY PURCHASING THIS SECURITY, REPRESENTS AND AGREES THAT IT IS NOT A U.S. PERSON NOR IS IT PURCHASING FOR THE ACCOUNT OF A U.S. PERSON AND IS ACQUIRING THIS SECURITY IN AN OFFSHORE TRANSACTION IN ACCORDANCE
WITH REGULATION S UNDER THE SECURITIES ACT. THE FOREGOING LEGEND MAY BE REMOVED FROM THIS SECURITY ONLY WITH THE CONSENT OF THE ISSUER.” 

7. In accordance with the terms of the applicable Exchange Offer (as defined in the Registration Rights Agreement), the Company will issue, and
upon receipt of a written order in accordance with Section 2.3 of the Indenture, the Trustee will authenticate: 
  

	 	(a)	 One or more Global Securities in an aggregate principal amount equal to the principal amount of the beneficial
interests in the Global Securities tendered into the applicable Exchange Offer pursuant to the terms of the Registration Rights Agreement; and 

  

	 	(b)	 Certificated Notes in an aggregate principal amount equal to the principal amount of the Certificated Notes
tendered into the Exchange Offer pursuant to the terms of the Registration Rights Agreement. 

 Such Global Securities and
Certificated Notes shall not contain the restrictive legend set forth in Item 6 above. Concurrently with the issuance of such Exchange Securities, the Company will instruct the Trustee to cause the aggregate principal amount of the applicable Global
Securities and Certificated Notes to be reduced accordingly. 
 8. The Notes shall be denominated in Dollars and payments of principal and
interest shall be made in Dollars. 
 9. In addition to the provisions set forth in Article IV of the Indenture, the following additional
provisions shall apply to the Notes and shall be incorporated into the Indenture with respect to the Notes: 

  
 3 

 Section 4.5 Change of Control Offer 

(a) If a Change of Control Triggering Event occurs, unless the Company has exercised its option to redeem the Notes as described in
Section 5 of the Security, the Company will be required to make an offer (the “Change of Control Offer”) to each Holder to repurchase all or any part (equal to $2,000 or an integral multiple of $1,000 in excess thereof) of that
Holder’s Notes on the terms set forth in such Security. In the Change of Control Offer, the Company shall be required to offer payment in cash equal to 101% of the aggregate principal amount of Notes repurchased, plus accrued and unpaid
interest, if any, on the Notes repurchased to the date of repurchase (the “Change of Control Payment”). Within 30 days following any Change of Control Triggering Event, a notice will be provided to Holders describing the transaction
that constitutes the Change of Control Triggering Event and offering to repurchase the Notes on the date specified in the notice, which date will be no earlier than 30 days and no later than 60 days from the date such notice is provided (the
“Change of Control Payment Date”); provided, however, that in no event will the Change of Control Payment Date occur prior to the date 90 days following the First Issue Date. 

(b) On the Change of Control Payment Date, the Company shall, to the extent lawful: 

 

	 	(i)	 accept for payment all Notes or portions of Notes properly tendered pursuant to the Change of Control Offer;

  

	 	(ii)	 deposit with the Paying Agent an amount equal to the Change of Control Payment in respect of all Notes or
portions of Notes properly tendered; and 

  

	 	(iii)	 deliver or cause to be delivered to the Trustee the Notes properly accepted together with an Officer’s
Certificate stating the aggregate principal amount of Notes or portions of Notes being repurchased. 

 (c) Notwithstanding
the foregoing, the Company shall not repurchase any Notes if there has occurred and is continuing on the Change of Control Payment Date an Event of Default under the Indenture, other than a Default in the payment of the Change of Control Payment
upon a Change of Control Triggering Event. 
 (d) The Company will comply with the requirements of Rule
14e-1 under the Exchange Act and any other securities laws and regulations thereunder to the extent those laws and regulations are applicable in connection with the repurchase of the Notes as a result of a
Change of Control Triggering Event. To the extent that the provisions of any such securities laws or regulations conflict with the Change of Control Offer provisions of the Notes, the Company will comply with those securities laws and regulations
and will not be deemed to have breached its obligations under the Change of Control Offer provisions of the Notes by virtue of any such conflict. 

(e) If holders of not less than 90% in aggregate principal amount of the outstanding Notes validly tender and do not withdraw such Notes in a
Change Of Control Offer and the Company, or any third party making such an offer in lieu of the Company, purchases all of the Notes validly tendered and not withdrawn by such holders, the Company or such third party will have the right, upon not
less than 10 days nor more than 60 days’ prior notice, provided that such notice is given not more than 30 days following such repurchase pursuant to the Change Of Control Offer described above, to redeem all Notes that remain outstanding

  
 4 

 
following such purchase on a date specified in such notice (the “Second Change Of Control Payment Date”) and at a price in cash equal to 101% of the aggregate principal amount of
Notes repurchased plus any accrued and unpaid interest on the Notes repurchased to, but not including, the Second Change Of Control Payment Date. 

(f) For the purposes of this Section 4.5 only, the following definitions shall apply: 

“Beneficial Owner” shall be determined in accordance with Rules 13d-3 and 13d-5 under the Exchange Act or any successor provisions, except that a Person will be deemed to have beneficial ownership of all shares that Person has the right to acquire irrespective of whether that right is
exercisable immediately or only after the passage of time. 
 “Change of Control” means
the    occurrence of any of the    following: (1) the consummation of any transaction (including, without limitation, any merger or consolidation) the result of which is that any Person or Group (other
than the Company or one of its Subsidiaries) becomes the Beneficial Owner, directly or indirectly, of more than 50% of the Company’s Voting Stock or other Voting Stock into which the Company’s Voting Stock is reclassified, consolidated,
exchanged or changed, measured by voting power rather than number of shares; provided, however, that a Person shall not be deemed Beneficial Owner of, or to own beneficially, (A) any securities tendered pursuant to a tender or
exchange offer made by or on behalf of such Person or any of such Person’s affiliates until such tendered securities are accepted for purchase or exchange thereunder, or (B) any securities if such beneficial ownership (i) arises
solely as a result of a revocable proxy delivered in response to a proxy or consent solicitation made pursuant to the applicable rules and regulations under the Exchange Act, and (ii) is not also then reportable on Schedule 13D (or any
successor schedule) under the Exchange Act; (2) the direct or indirect sale, transfer, conveyance or other disposition (other than by way of merger or consolidation), in one or more series of related transactions, of all or substantially all of
the Company’s assets and the assets of the Company’s Subsidiaries, taken as a whole, to one or more Persons or Groups (other than the Company or one of its Subsidiaries); provided that none of the circumstances in this clause
(2) will be a Change of Control if the Persons that beneficially own the Company’s Voting Stock immediately prior to the transaction own, directly or indirectly, shares with a majority of the total voting power of all outstanding voting
securities of the surviving or transferee Person that are entitled to vote generally in the election of that Person’s board of directors, managers or trustees immediately after the transaction; or (3) the adoption of a plan relating to the
Company’s liquidation or dissolution.    Notwithstanding the foregoing, a transaction will not be deemed to involve a Change of Control under clause (1) above if (i) the Company becomes a direct or indirect
wholly-owned subsidiary of a holding company and (ii) (A) the direct or indirect holders of the Voting Stock of such holding company immediately following that transaction are substantially the same as the holders of the Company’s Voting
Stock immediately prior to that transaction or (B) immediately following that transaction no Person (other than a holding company satisfying the requirements of this sentence) is the Beneficial Owner, directly or indirectly, of more than 50% of
the Voting Stock of such holding company. 

  
 5 

 “Change of Control Triggering Event” means the occurrence of both a Change
of Control and a Rating Event. 
 “Group” has the meaning given by Section 13(d) and 14(d) of the Exchange Act or any
successor provisions and includes any group acting for the purpose of acquiring, holding or disposing of securities within the meaning of Rule 13d-5(b)(1) under the Exchange Act or any successor provision.

 “Investment Grade Rating” means a rating equal to or higher than Baa3 (or the equivalent) by Moody’s and BBB- (or the equivalent) by S&P, and the equivalent investment grade credit rating from any additional Rating Agency or Rating Agencies selected by the Company. 

“Moody’s” means Moody’s Investors Service, Inc., and its successors. 

“Person” has the meaning given by Section 13(d) and 14(d) of the Exchange Act or any successor provisions. 

“Rating Agencies” means (1) each of Moody’s and S&P; and (2) if either Moody’s or S&P ceases to
rate the Notes or fails to make a rating of the Notes publicly available for reasons outside of the Company’s control, a “nationally recognized statistical rating organization” within the meaning of Section 3(a)(62) of the
Exchange Act selected by the Company (as certified by a resolution of the Board of Directors) as a replacement agency for Moody’s or S&P, or both of them, as the case may be. 

“Rating Event” means the rating on the Notes is lowered by both of the Rating Agencies and the Notes are rated below an
Investment Grade Rating by both of the Rating Agencies on any day during the period commencing 60 days prior to the first public notice of the occurrence of a Change of Control or the Company’s intention to effect a Change of Control and ending
60 days following consummation of such Change of Control (which period will be extended so long as the rating of the Notes is under publicly announced consideration for a possible downgrade by any of the Rating Agencies). 

“S&P” means Standard & Poor’s Rating Services, a division of The McGraw-Hill Companies, Inc., and its
successors. 
 “Voting Stock” as applied to stock of any Person, means shares, interests, participations or other
equivalents in the equity interest (however designated) in such Person having ordinary voting power for the election of a majority of the directors (or the equivalent) of such Person, other than shares, interests, participations or other equivalents
having such power only by reason of the occurrence of a contingency. 
 Section 4.6 Limitation on Liens. 

(a) The Company shall not, nor shall it permit any of its Subsidiaries to, create or incur any Lien on any of their respective Properties,
whether now owned or hereafter acquired, or upon any income or profits therefrom, in order to secure any Indebtedness of the Company, without effectively providing that the Notes shall be equally and ratably secured until such time as such
Indebtedness is no longer secured by such Lien, except: 

  
 6 

 (1) Liens existing as of the First Issue Date; 

(2) Liens granted after the First Issue Date on any of the Company or any of its Subsidiaries’ Properties securing Indebtedness of the
Company created in favor of the Holders of the Notes; 
 (3) Liens securing Indebtedness of the Company which are incurred to extend, renew
or refinance Indebtedness which is secured by Liens permitted to be incurred under the Indenture; provided that those Liens do not extend to or cover any of the Company or any of its Subsidiaries’ Property other than the Property securing the
Indebtedness being refinanced and that the principal amount of such Indebtedness does not exceed the principal amount of the Indebtedness being refinanced; 

(4) Liens created in substitution of or as replacements for any Liens permitted by the preceding clauses (1) through (3) directly above,
provided that, based on a good faith determination of an Officer of the Company, the Property encumbered under any such substitute or replacement Lien is substantially similar in nature to the Property encumbered by the otherwise permitted Lien
which is being replaced; and 
 (5) Permitted Liens. 

(b) Notwithstanding the foregoing, the Company and any of its Subsidiaries may, without securing the Notes, create or incur Liens which would
otherwise be subject to the restrictions set forth in the preceding paragraph, if after giving effect thereto, Exempted Debt does not exceed the greater of (x) 35% of Consolidated Net Worth calculated as of the date of the creation or incurrence of
the Lien or (y) 35% of Consolidated Net Worth calculated as of the First Issue Date. 
 Section 4.7 Limitation on Sale and Lease-Back
Transactions. 
 (a) The Company shall not and shall not permit any of its Subsidiaries to, enter into any sale and lease-back
transaction for the sale and leasing back of any Property, whether now owned or hereafter acquired, of the Company or any Subsidiary of the Company, unless: 

(1) such transaction was entered into prior to the First Issue Date; 

(2) such transaction was for the sale and leasing back of any Property by a Subsidiary of the Company to the Company; 

(3) such transaction involves a lease for less than three years; 

(4) the Company would be entitled to incur Indebtedness secured by a mortgage on the Property to be leased in an amount equal to the
Attributable Liens with respect to such sale and lease-back transaction without equally and ratably securing the Notes pursuant to Section 4.6; or 

(5) the Company applies an amount equal to the fair value of the proceeds of the Property sold to the purchase of Property or to the retirement
of long-term Indebtedness of the Company or any of its Subsidiaries within 120 days of the effective date of any such sale and lease-back transaction. In lieu of applying such amount to such retirement, the Company may, or may cause any of its
Subsidiaries to, deliver debt securities to the Trustee therefor for cancellation, such debt securities to be credited at the cost thereof to the Company. 

  
 7 

 (b) Notwithstanding the foregoing, the Company and any of its Subsidiaries may enter into
any sale and lease-back transaction which would otherwise be subject to the foregoing restrictions if after giving effect thereto and at the time of determination, Exempted Debt does not exceed the greater of (a) 35% of Consolidated Net Worth
calculated as of the closing date of the sale and lease-back transaction or (b) 35% of Consolidated Net Worth calculated as of the First Issue Date. 

10. In addition to the definitions set forth in Article I of the Indenture, the Notes shall include the following additional definitions,
which, in the event of a conflict with the definition of terms in the Indenture, shall control: 
 “Attributable Liens”
means in connection with a sale and lease-back transaction the lesser of: 
 (1) the fair market value of the assets subject to such
transaction; and 
 (2) the present value (discounted at a rate per annum equal to the average interest borne by all outstanding debt
securities issued under the Indenture (which may include debt securities in addition to the Notes) determined on a weighted average basis and compounded semi-annually) of the obligations of the lessee for rental payments during the term of the
related lease. 
 “Business Day” means any day except a Saturday, Sunday or a legal holiday in the City of New York, New
York (or in connection with any payment, the place of payment) on which banking institutions are authorized or required by law, regulation or executive order to close. 

“Consolidated Net Worth” means, as of any date of determination, the Stockholders’ Equity of the Company and its
Consolidated Subsidiaries on that date. 
 “Consolidated Subsidiary” means, as of any date of determination and with respect
to any Person, any Subsidiary of that Person whose financial data is, in accordance with GAAP, reflected in that Person’s consolidated financial statements. 

“Credit Facilities” means, one or more debt facilities (including, without limitation, the Revolving Credit Agreement) or
commercial paper facilities, in each case, with banks or other institutional lenders providing for revolving credit loans, term loans, receivables financing (including through the sale of receivables to such lenders or to special purpose entities
formed to borrow from such lenders against such receivables) or letters of credit, in each case, as amended, restated, modified, renewed, refunded, replaced (whether upon or after termination or otherwise) or refinanced (including by means of sales
of debt securities to institutional investors) in whole or in part from time to time. 
 “Exempted Debt” means the sum of
the following as of the date of determination: 
 (1) Indebtedness of the Company incurred after the First Issue Date and secured by Liens
not permitted by Section 4.6(a) above; and 

  
 8 

 (2) Attributable Liens of the Company and any of its Subsidiaries in respect of sale and
lease-back transactions entered into after the First Issue Date pursuant to Section 4.7(b) above. 
 “Finance Lease”
means, as to any Person, a lease of any Property by that Person as lessee that is, or should be recorded as a “finance lease” on the balance sheet of that Person prepared in accordance with GAAP. 

“First Issue Date” means August 17, 2020. 

“GAAP” means accounting principles generally accepted in the United States set forth in the Accounting Standards Codification
of the Financial Accounting Standards Board or in such other documents by such other entity as have been approved by a significant segment of the accounting profession, which are in effect as of the date of determination. 

“Governmental Agency” means: 

(1) any foreign, federal, state, county or municipal government, or political subdivision thereof; 

(2) any governmental or quasi-governmental agency, authority, board, bureau, commission, department, instrumentality or public body; 

(3) any court or administrative tribunal; and 

(4) with respect to any Person, any arbitration tribunal or other nongovernmental authority to whose jurisdiction that Person has consented.

 “Hedging Obligations” means, with respect to any specified Person, the obligations of such Person under: 

(1) interest rate swap agreements (whether from fixed to floating or from floating to fixed), interest rate cap agreements and interest rate
collar agreements; 
 (2) other agreements or arrangements designed to manage interest rates or interest rate risk; and 

(3) other agreements or arrangements designed to protect such Person against fluctuations in currency exchange rates or commodity prices. 

“Indebtedness” of any Person means, without duplication, any indebtedness, whether or not contingent, in respect of borrowed
money or evidenced by bonds, notes, debentures or similar instruments or letters of credit (or reimbursement agreements with respect thereto) or representing the balance deferred and unpaid of the purchase price of any Property (including pursuant
to Finance Leases), except any such balance that constitutes an accrued expense or trade payable, if and to the extent any of the foregoing indebtedness would appear as a liability upon a balance sheet of such Person prepared on a consolidated basis
in accordance with GAAP (but does not include contingent liabilities which appear only in a footnote to a balance sheet), and shall also include, to the extent not otherwise included, the guaranty of items which would be included within this
definition. 

  
 9 

 “Laws” means, collectively, all foreign, federal, state and local statutes,
treaties, rules, regulations, ordinances, codes and administrative or controlling precedents of any Governmental Agency. 

“Lien” means any lien, security interest, charge or encumbrance of any kind (including any conditional sale or other title
retention agreement, any lease in the nature thereof, and any agreement to give any security interest). 
 “Make-Whole
Amount” means the excess of (1) the net present value, on the redemption date, of the principal being redeemed or paid and the amount of interest (exclusive of interest accrued to the date of redemption) that would have been payable if
such redemption had not been made (calculated as if the maturity date of the Notes was the par call date relating to the Notes, to the extent applicable), over (2) the aggregate principal amount of such Notes being redeemed or paid. Net present
value shall be determined by discounting, on a semi-annual basis, such principal and interest at the Reinvestment Rate (as defined below and as determined on the third Business Day preceding the date of redemption) from the respective dates on which
such principal and interest would have been payable if such redemption had not been made. 
 “Permitted Liens” means: 

(1) Liens securing Indebtedness under Credit Facilities; 

(2) Liens on accounts receivable, merchandise inventory, equipment, and patents, trademarks, trade names and other intangibles, securing
Indebtedness of the Company; 
 (3) Liens on any assets of the Company, any of its Subsidiaries’ assets, or the assets of any joint
venture to which the Company or any of its Subsidiaries is a party, created solely to secure obligations incurred to finance the refurbishment, improvement or construction of such asset, which obligations are incurred no later than 24 months after
completion of such refurbishment, improvement or construction, and all renewals, extensions, refinancings, replacements or refundings of such obligations; 

(4) (a) Liens given to secure the payment of the purchase price incurred in connection with the acquisition (including acquisition through
merger or consolidation) of Property (including shares of stock), including Finance Lease transactions in connection with any such acquisition, and (b) Liens existing on Property at the time of acquisition thereof or at the time of acquisition
by the Company or one of its Subsidiaries of any Person then owning such Property whether or not such existing Liens were given to secure the payment of the purchase price of the Property to which they attach; provided that, with respect to clause
(a), the Liens shall be given within 24 months after such acquisition and shall attach solely to the Property acquired or purchased and any improvements then or thereafter placed thereon; 

(5) Liens in favor of customs and revenue authorities arising as a matter of law to secure payment of customs duties in connection with the
importation of goods; 

  
 10 

 (6) Liens upon specific items of inventory or other goods and proceeds of any Person
securing such Person’s obligations in respect of bankers’ acceptances issued or created for the account of such Person to facilitate the purchase, shipment or storage of such inventory or other goods; 

(7) Liens securing reimbursement obligations with respect to letters of credit that encumber documents and other Property relating to such
letters of credit and the products and proceeds thereof; 
 (8) Liens on key-man life insurance
policies granted to secure Indebtedness of the Company against the cash surrender value thereof; 
 (9) Liens encumbering customary initial
deposits and margin deposits and other Liens in the ordinary course of business, in each case securing Hedging Obligations and forward contract, option, futures contracts, futures options or similar agreements or arrangements designed to protect the
Company or any of its Subsidiaries from fluctuations in interest rates, currencies or the price of commodities; 
 (10) Liens arising out of
conditional sale, title retention, consignment or similar arrangements for the sale of goods entered into by Company or any of its Subsidiaries in the ordinary course of business; 

(11) pre-existing Liens on assets acquired by the Company or any of its Subsidiaries after the First
Issue Date; 
 (12) Liens in favor of the Company or in favor of any of its Subsidiaries; 

(13) inchoate Liens incident to construction or maintenance of real property, or Liens incident to construction or maintenance of real
property, now or hereafter filed of record for sums not yet delinquent or being contested in good faith, if reserves or other appropriate provisions, if any, as shall be required by GAAP shall have been made therefore; 

(14) statutory Liens arising in the ordinary course of business with respect to obligations which are not delinquent or are being contested in
good faith, if reserves or other appropriate provisions, if any, as shall be required by GAAP shall have been made therefore; 
 (15) Liens
consisting of pledges or deposits to secure obligations under workers’ compensation laws or similar legislation, including Liens of judgments thereunder which are not currently dischargeable; 

(16) Liens consisting of pledges or deposits of Property to secure performance in connection with operating leases made in the ordinary course
of business to which Company or any of its Subsidiaries is a party as lessee, provided the aggregate value of all such pledges and deposits in connection with any such lease does not at any time exceed
162⁄3% of the annual fixed rentals payable under such lease; 

(17) Liens consisting of deposits of Property to secure statutory obligations of the 

Company or statutory obligations of any of its Subsidiaries in the ordinary course of its business; 

  
 11 

 (18) Liens consisting of deposits of Property to secure (or in lieu of) surety, appeal or
customs bonds in proceedings to which the Company or any of its Subsidiaries is a party in the ordinary course of its business, but not in excess of $75,000,000; 

(19) purchase money Liens or purchase money security interests upon or in any Property acquired or held by Company or any of its Subsidiaries
in the ordinary course of business to secure the purchase price of such Property or to secure Indebtedness incurred solely for the purpose of financing the acquisition of such Property; 

(20) Liens on an asset created in connection with the acquisition, construction or development of additions, extensions or improvements to such
asset which shall be financed by obligations described in Sections 142, 144(a) or 144(c) of the Internal Revenue Code of 1986, as amended, or by obligations entitled to substantially similar tax benefits under other legislation or regulations in
effect from time to time; and 
 (21) Liens on Property subject to escrow or similar arrangements established in connection with litigation
settlements. 
 “Person” means any individual, corporation, partnership, joint venture, association, limited liability
company, joint-stock company, trust, unincorporated organization or government or any agency or political subdivision thereof. 

“Property” means any property or asset, whether real, personal or mixed, or tangible or intangible. 

“Reinvestment Rate” means 0.25% plus the weekly yield for the most recent week set forth in the most recent Statistical
Release (as defined below) for the constant maturity U.S. Treasury security (rounded to the nearest month) corresponding to the remaining life to maturity, as of the payment date of the principal being redeemed or paid. If no maturity exactly
corresponds to such maturity, yields for the two published maturities most closely corresponding to such maturity shall be calculated pursuant to the immediately preceding sentence and the Reinvestment Rate shall be interpolated or extrapolated from
such yields on a straight-line basis, rounding in each of such relevant periods to the nearest month. For the purpose of calculating the Reinvestment Rate, the most recent Statistical Release published prior to the date of determination of the
Make-Whole Amount shall be used. 
 “Revolving Credit Agreement” means the Second Amended and Restated Credit Agreement,
dated as of December 12, 2019, among the Company, the banks therein named, Citibank, N.A., as administrative agent, JPMorgan Chase Bank, N.A., as syndication agent, and Citibank, N.A., JPMorgan Chase Bank, N.A., Barclays Bank PLC, BofA
Securities, Inc., Goldman Sachs Bank USA and Morgan Stanley Senior Funding, Inc., as joint lead arrangers and joint book runners, as such agreement may be further amended (including any amendment, restatement, refinancing and successors thereof),
supplemented or otherwise modified from time to time, including any increase in the principal amount of the obligations thereunder. 

“Rule 144A” means Rule 144A under the Securities Act. 

  
 12 

 “Securities Act” means the U.S. Securities Act of 1933, as amended. 

“Statistical Release” means the statistical release designated “H.15” or any comparable online data source or
publication which is made available by the Federal Reserve System and which establishes yields on actively traded U.S. government securities adjusted to constant maturities, or, if such Statistical Release is not published at the time of any
determination under the Indenture, then such other reasonably comparable index which shall be designated by the Company. 

“Stockholders’ Equity” means, as of any date of determination, stockholders’ equity as of that date determined in
accordance with GAAP; provided that there shall be excluded from Stockholders’ Equity any amount attributable to capital stock that is, directly or indirectly, required to be redeemed or repurchased by the issuer thereof at a specified
date or upon the occurrence of specified events or at the election of the holder thereof. 
 “Subsidiary” of any specified
person means any corporation, association or other business entity of which more than 50% of the total voting power of shares of capital stock entitled (without regard to the occurrence of any contingency) to vote in the election of directors,
managers or trustees thereof is at the time owned or controlled, directly or indirectly, by such person or one or more of the other Subsidiaries of that person or a combination thereof. 

11. Section 9.1(h) of the Indenture shall be amended and restated solely with respect to the Notes as follows: 

(h) to make any change that does not adversely affect the rights of any Securityholder in any material respect; 

12. Pursuant to Section 3.4 of the Indenture, solely with respect to the Notes, notices of redemption sent by the Company pursuant to the
Indenture may be conditional. 
 13. The Depository for the Notes shall be The Depository Trust Company (“DTC”). 

14. The undersigned is authorized to approve the form, terms and conditions of the Notes. 

15. The undersigned has read the provisions of the Indenture, including the covenants and conditions precedent, pertaining to the issuance of
the Notes. 
 16. In connection with this Certificate, the undersigned has examined the documents, corporate records and certificates and has
made such inquiries of the other officers of the Company, which he or she has deemed necessary to enable him or her to express an informed opinion as to whether or not such comments and conditions have been complied with. 

17. In the opinion of the undersigned, all of the conditions and covenants related to the issuance of the Notes have been complied with. 

[Signature follows] 

  
 13 

 IN WITNESS WHEREOF, the undersigned has executed this Officer’s Certificate as
of the date first set forth above. 
  

			
	By:	 	 /s/ Justin G. Claeys

	Name:	 	Justin G. Claeys
	Title:	 	Vice President, Finance and Treasurer

 Signature Page to Officer’s Certificate for the Notes 

 Annex A 

Form of 2053 Note 
 [Face
of Rule 144A Note due 2053] 
 Rule 144A CUSIP 031162 CX6 

2.770% Senior Notes due 2053 
  

			
	No.144A-__	  	$________

 AMGEN INC. 

promises to pay to CEDE & CO. or registered assigns, the principal 

sum of ___________ DOLLARS on September 1, 2053. 

Interest Payment Dates: March 1 and September 1 

Record Dates: 15th day prior to March 1 and September 1 

Dated:  
  

			
	AMGEN INC.
		
	By:	 	  

		 	Name:
		 	Title:

 This is one of the Notes referred to in the 

within-mentioned Indenture: 
  

			
	THE BANK OF NEW YORK MELLON TRUST
	COMPANY, N.A., as Trustee
		
	By:	 	  

		 	Authorized Officer
	
	Authentication Date: _________________

 [REVERSE SIDE OF RULE 144A NOTE] 

2.770% SENIOR NOTES DUE 2053 

THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF THE DEPOSITORY
OR A NOMINEE OF THE DEPOSITORY. THIS SECURITY IS EXCHANGEABLE FOR SECURITIES REGISTERED IN THE NAME OF A PERSON OTHER THAN THE DEPOSITORY OR ITS NOMINEE ONLY IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE, AND MAY NOT BE TRANSFERRED EXCEPT
AS A WHOLE BY THE DEPOSITORY TO A NOMINEE OF THE DEPOSITORY, BY A NOMINEE OF THE DEPOSITORY TO THE DEPOSITORY OR ANOTHER NOMINEE OF THE DEPOSITORY OR BY THE DEPOSITORY OR ANY SUCH NOMINEE TO A SUCCESSOR DEPOSITORY OR A NOMINEE OF SUCH A SUCCESSOR
DEPOSITORY. 
 UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY TO THE ISSUER OR ITS
AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY (AND ANY
PAYMENT HEREON IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL
SINCE THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN. 
 THIS SECURITY HAS NOT BEEN REGISTERED UNDER THE U.S.
SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR THE SECURITIES LAWS OF ANY STATE OR OTHER JURISDICTION. NEITHER THIS SECURITY NOR ANY INTEREST OR PARTICIPATION HEREIN MAY BE RESOLD, PLEDGED OR TRANSFERRED IN THE ABSENCE OF
SUCH REGISTRATION OR UNLESS SUCH TRANSACTION IS EXEMPT FROM, OR NOT SUBJECT TO, SUCH REGISTRATION. THE HOLDER HEREOF, BY PURCHASING THIS SECURITY, AGREES ON ITS OWN BEHALF AND ON BEHALF OF ANY INVESTOR ACCOUNT FOR WHICH IT HAS PURCHASED SECURITIES,
THAT THIS SECURITY OR ANY INTEREST OR PARTICIPATION HEREIN MAY BE OFFERED, RESOLD, PLEDGED OR OTHERWISE TRANSFERRED ONLY (I) TO AMGEN INC. (THE “ISSUER”) OR ANY OF ITS SUBSIDIARIES, (II) SO LONG AS THIS SECURITY IS ELIGIBLE FOR
RESALE PURSUANT TO RULE 144A UNDER THE SECURITIES ACT (“RULE 144A”), TO A PERSON THE SELLER REASONABLY BELIEVES IS A QUALIFIED INSTITUTIONAL BUYER (AS DEFINED IN RULE 144A) IN ACCORDANCE WITH RULE 144A, (III) IN AN OFFSHORE
TRANSACTION TO A NON-U.S. PERSON IN ACCORDANCE WITH RULE 903 OR 904 OF REGULATION S UNDER THE SECURITIES ACT, (IV) PURSUANT TO AN EXEMPTION FROM REGISTRATION PROVIDED BY RULE 144 UNDER THE SECURITIES ACT
(IF AVAILABLE), OR (V) PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT, AND IN EACH OF SUCH CASES IN ACCORDANCE WITH ANY APPLICABLE SECURITIES LAWS OF ANY STATE OF THE UNITED STATES OR OTHER APPLICABLE JURISDICTION. THE
HOLDER HEREOF, BY PURCHASING THIS SECURITY, REPRESENTS AND AGREES THAT IT WILL NOTIFY ANY PURCHASER OF THIS SECURITY FROM IT OF THE RESALE RESTRICTIONS REFERRED TO ABOVE. THE FOREGOING LEGEND MAY BE REMOVED FROM THIS SECURITY ONLY WITH THE CONSENT
OF THE ISSUER. 

 Capitalized terms used herein have the meanings assigned to them in the Indenture referred to below unless
otherwise indicated. 
  

	(1)	 INTEREST. Amgen Inc., a Delaware corporation (the “Company”), promises to pay interest on the
principal amount of this Note at 2.770% per annum from August 17, 2020 until maturity. The Company will pay interest in cash semi-annually in arrears on March 1 and September 1 of each year, or if any such day is not a Business Day,
on the next succeeding Business Day (each, an “Interest Payment Date”). Interest on the Notes will accrue from the most recent date to which interest has been paid or, if no interest has been paid, from the date of issuance;
provided that the first Interest Payment Date shall be March 1, 2021; provided further that after March 1, 2021, if there is no existing Default in the payment of interest, and if this Note is authenticated between a record
date referred to on the face hereof and the next succeeding Interest Payment Date, interest shall accrue from such next succeeding Interest Payment Date. The interest rate will be computed on the basis of a
360-day year of twelve 30-day calendar months. 

  

	(2)	 METHOD OF PAYMENT. The Company will pay interest on the Notes (except defaulted interest) to the Persons who
are registered Holders of Notes at the close of business on the day that is 15 days prior to the next succeeding Interest Payment Date (whether or not such day is a Business Day), even if such Notes are canceled after such record date and on or
before such Interest Payment Date, except as provided in Section 2.13 of the Indenture with respect to defaulted interest. The Notes will be payable as to principal and interest at the office or agency of the Company maintained for such purpose
in the Borough of Manhattan, the City and State of New York (or, if the Company fails to maintain such office or agency, at the corporate trust office of the trustee in New York, New York or if the trustee does not maintain an office in New York, at
the office of a paying agent in New York), or, at the option of the Company, payment of interest may be made by check mailed to the Holders at their addresses set forth in the register of Holders; provided that payment by wire transfer of
immediately available funds will be required with respect to principal of and interest on all Global Securities and all other Notes the Holders of which will have provided wire transfer instructions to the Company or the Paying Agent. Such payment
will be in the currency of the United States of America. 

  

	(3)	 PAYING AGENT AND REGISTRAR. Initially, The Bank of New York Mellon Trust Company, N.A., the Trustee under the
Indenture, will act as Paying Agent and Registrar. The Company may change any Paying Agent or Registrar without notice to any Holder. The Company or any of its Subsidiaries may act in any such capacity. 

 

	(4)	 INDENTURE. The terms of the Notes include those stated in the Indenture dated May 22, 2014, between the
Company and the Trustee (the “Indenture”), and those made part of the Indenture by the Officer’s Certificate dated August 17, 2020, delivered pursuant thereto (the “Officer’s Certificate”) and the
TIA. The Notes are subject to all such terms, and the Holders are referred to the Indenture and the TIA for a statement of them. 

  

	(5)	 OPTIONAL REDEMPTION. At any time prior to maturity, the Company will have the option to redeem all or a part of
the Notes upon not less than 10 nor more than 60 days’ notice. If the Notes are redeemed before March 1, 2053 (six months prior to the maturity date of the Notes), the redemption price will equal the sum of (1) 100% of the principal amount
of any Notes being redeemed, plus accrued and unpaid interest to, but not including, the redemption date, and (2) the Make-Whole Amount. If the Notes are redeemed on or after March 1, 2053 (six months prior to the maturity date of the
Notes), the redemption price will equal 100% of the principal amount being redeemed, plus accrued and unpaid interest to, but not including, the redemption date. Unless the Company defaults in the payment of the redemption price, interest will cease
to accrue on the Notes or portions thereof called for redemption on the applicable redemption date. 

	(6)	 NOTICE OF REDEMPTION. Notice of redemption will be mailed at least 10 days but not more than 60 days before the
redemption date to each Holder whose Notes are to be redeemed at its registered address, except that redemption notices may be mailed more than 60 days prior to a redemption date if the notice is issued in connection with a defeasance of the Notes
or a satisfaction or discharge of the Indenture. Notes in denominations larger than $2,000 may be redeemed in part but only in whole multiples of $1,000, unless all of the Notes held by a Holder are to be redeemed. Notices of redemption for the
Notes may be conditional. 

  

	(7)	 MANDATORY REDEMPTION. Except as provided in Section 8 below, the Company is not required to make mandatory
redemption or sinking fund payments with respect to the Notes. 

  

	(8)	 CHANGE OF CONTROL TRIGGERING EVENT. In the event of a Change of Control Triggering Event, the Holders may
require the Company to purchase for cash all or a portion of their Notes at a purchase price equal to 101% of the principal amount of the notes, plus accrued and unpaid interest, if any, pursuant to the provisions of Section 9 of the
Officer’s Certificate. If holders of not less than 90% in aggregate principal amount of the outstanding Notes validly tender and do not withdraw such Notes in a Change Of Control Offer and the Company, or any third party making such an offer in
lieu of the Company, purchases all of the Notes validly tendered and not withdrawn by such holders, the Company or such third party will have the right, upon not less than 10 days nor more than 60 days’ prior notice, provided that such notice
is given not more than 30 days following such repurchase pursuant to the Change Of Control Offer described above, to redeem all Notes that remain outstanding following such purchase on a date specified in such notice (the “Second Change Of
Control Payment Date”) and at a price in cash equal to 101% of the aggregate principal amount of Notes repurchased plus any accrued and unpaid interest on the Notes repurchased to, but not including, the Second Change Of Control Payment
Date. 

  

	(9)	 DEFEASANCE PRIOR TO MATURITY. The Indenture contains provisions for defeasance of (i) the entire
indebtedness of the Notes or (ii) certain covenants and Events of Default with respect to the Notes, in each case upon compliance with certain conditions set forth therein. 

 

	(10)	 RESTRICTIVE COVENANTS. The Indenture and the Officer’s Certificate impose certain limitations on the
Company and its Subsidiaries, including limitations on the Company’s and its Subsidiaries’ ability to create or incur certain Liens on any of their respective properties or assets and to enter into certain sale and lease-back transactions
and on the Company’s ability to engage in mergers or consolidations or the conveyance, transfer or lease of all or substantially all of its properties and assets. These limitations are subject to a number of important qualifications and
exceptions and reference is made to the Indenture and the Officer’s Certificate for a description thereof. 

  

	(11)	 DENOMINATIONS, TRANSFER, EXCHANGE. The Notes are in registered form without coupons in denominations of $2,000
and integral multiples of $1,000. The transfer of Notes may be registered and Notes may be exchanged as provided in the Indenture. The Registrar and the Trustee may require a Holder, among other things, to furnish appropriate endorsements and
transfer documents and the Company may require a Holder to pay any taxes and fees required by law or permitted by the Indenture. The Company need not exchange or register the transfer of any Note or portion of a Note selected for redemption, except
for the unredeemed portion of any Note being redeemed in part. Also, the Company need not exchange or register the transfer of any Notes for a period of 15 days before a selection of Notes to be redeemed or during the period between a record date
and the corresponding Interest Payment Date. 

  

	(12)	 PERSONS DEEMED OWNERS. The registered Holder of a Note may be treated as its owner for all purposes.

	(13)	 AMENDMENT, SUPPLEMENT AND WAIVER. Subject to certain exceptions, the Indenture or the Notes may be amended or
supplemented with the consent of the Holders of at least a majority in aggregate principal amount of the then outstanding Notes voting as a single class, and any existing Default or Event or Default or compliance with any provision of the Indenture
or the Notes may be waived with the consent of the Holders of a majority in aggregate principal amount of the then outstanding Notes voting as a single class. Without the consent of any Holder of a Note, the Indenture or the Notes may be amended or
supplemented to cure any ambiguity, defect or inconsistency; to comply with Article V of the Indenture; to provide for uncertificated Notes in addition to or in place of certificated Notes; to add guarantees with respect to the Notes or secure the
Notes; to surrender any of the Company’s rights or powers under the Indenture; to add covenants or events of default for the benefit of the Holders of the Notes; to comply with the applicable procedures of the applicable depositary; to make any
change that would not adversely affect the rights under the Indenture of any such Holder in any material respect; to provide for the issuance of and establish the form and terms and conditions of Notes of any series as permitted by the Indenture; to
evidence and provide for the acceptance of appointment under the Indenture by a successor trustee with respect to the Notes and to add to or change any of the provisions of the Indenture necessary to provide for the administration of the trusts in
the Indenture by more than one trustee; or to comply with the requirements of the SEC in order to effect or maintain the qualification of the Indenture under the TIA. No amendment to cure any ambiguity, defect or inconsistency in the Indenture made
solely to conform the Indenture to the description of notes contained in the Confidential Offering Circular related to the Notes, dated July 30, 2020, will be deemed to adversely affect the interests of the Holders of the Notes.

  

	(14)	 DEFAULTS AND REMEDIES. If an Event of Default shall occur and be continuing, the principal of the Notes may be
declared (or, in certain cases, shall ipso facto become) due and payable in the manner and with the effect provided in the Indenture. 

  

	(15)	 TRUSTEE DEALINGS WITH COMPANY. The Trustee under the Indenture, in its individual or any other capacity, may
deal with the Company or an Affiliate of the Company with the same rights it would have if it were not Trustee. 

  

	(16)	 NO RECOURSE AGAINST OTHERS. A director, officer, employee or stockholder of the Company shall not have any
liability for any obligations of the Company under the Notes or the Indenture or for any claim based on, in respect of, or by reason of, such obligations or their creation. Each Holder by accepting a Note waives and releases all such liability. The
waiver and release are part of the consideration for the issuance of the Notes. 

  

	(17)	 AUTHENTICATION. This Note will not be valid until authenticated by the manual signature of the Trustee or an
authenticating agent. 

  

	(18)	 ABBREVIATIONS. Customary abbreviations may be used in the name of a Holder or an assignee, such as: TEN COM (=
tenants in common), TEN ENT (= tenants by the entireties), JT TEN (= joint tenants with right of survivorship and not as tenants in common), CUST (= Custodian), and U/G/M/A (= Uniform Gifts to Minors Act). 

 

	(19)	 REGISTRATION RIGHTS OF HOLDERS. In addition to the rights provided to Holders of Notes under the Indenture,
Holders of restricted Notes will have all the rights set forth in the Registration Rights Agreement, dated as of August 17, 2020, between the Company and the dealer managers named on the signature pages thereof (the “Registration Rights
Agreement”). 

	(20)	 CUSIP NUMBERS. Pursuant to a recommendation promulgated by the Committee on Uniform Security Identification
Procedures, the Company has caused CUSIP numbers to be printed on the Notes, and the Trustee may use CUSIP numbers in notices of redemption as a convenience to Holders. No representation is made as to the accuracy of such numbers either as printed
on the Notes or as contained in any notice of redemption, and reliance may be placed only on the other identification numbers placed thereon. 

  

	(21)	 GOVERNING LAW. THE INDENTURE AND THIS NOTE, INCLUDING ANY CLAIM OR CONTROVERSY ARISING OUT OF OR RELATED TO THE
INDENTURE OR THIS NOTE, SHALL BE GOVERNED BY THE LAWS OF THE STATE OF NEW YORK. 

 The Company will furnish to any Holder upon written
request and without charge a copy of the Indenture, the Officer’s Certificate and/or the Registration Rights Agreement. 

Requests may be made to: 

Amgen Inc. 
 One Amgen Center Drive

 Thousand Oaks, CA 91320-1799 

Attention: Investor Relations 

 ASSIGNMENT FORM 

To assign this Note, fill in the form below: 
  

			
	(I) or (we) assign and transfer this Note to:	 	                                      
                                         
                 
		 	    (Insert assignee’s legal name)

  
  

(Insert assignee’s soc. sec. or tax I.D. no.) 
  

 
  

 
  

 
  

 
 (Print or type assignee’s name,
address and zip code) 
 and irrevocably appoint________________________________________________________________________________ 

to transfer this Note on the books of the Company. The agent may substitute another to act for him. 

Date: ____________________  
  

			
	Your Signature:	 	  

		 	(Sign exactly as your name appears on the face of this Note)

 Signature Guarantee*: ______________________ 

 

	*	 Participant in a recognized Signature Guarantee Medallion Program (or other signature guarantor acceptable to
the Trustee). 

 [Face of Reg S Note due 2053] 

Reg S CUSIP U03160 AX3 
 2.770%
Senior Notes due 2053 
  

			
	No. Reg S-    	  	$________

 AMGEN INC. 

promises to pay to CEDE & CO. or registered assigns, the principal 

sum of ___________ DOLLARS on September 1, 2053. 

Interest Payment Dates: March 1 and September 1 

Record Dates: 15th day prior to March 1 and September 1 

Dated:  
  

			
	AMGEN INC.
		
	By:	 	  

		 	Name:
		 	Title:

 This is one of the Notes referred to 

in the within-mentioned Indenture: 
  

			
	THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A., as Trustee
		
	By:	 	  

		 	Authorized Officer
	
	Authentication Date: _________________

 [REVERSE SIDE OF REG S NOTE] 

2.770% SENIOR NOTES DUE 2053 

THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF THE DEPOSITORY
OR A NOMINEE OF THE DEPOSITORY. THIS SECURITY IS EXCHANGEABLE FOR SECURITIES REGISTERED IN THE NAME OF A PERSON OTHER THAN THE DEPOSITORY OR ITS NOMINEE ONLY IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE, AND MAY NOT BE TRANSFERRED EXCEPT
AS A WHOLE BY THE DEPOSITORY TO A NOMINEE OF THE DEPOSITORY, BY A NOMINEE OF THE DEPOSITORY TO THE DEPOSITORY OR ANOTHER NOMINEE OF THE DEPOSITORY OR BY THE DEPOSITORY OR ANY SUCH NOMINEE TO A SUCCESSOR DEPOSITORY OR A NOMINEE OF SUCH A SUCCESSOR
DEPOSITORY. 
 UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY TO THE ISSUER OR ITS
AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY (AND ANY
PAYMENT HEREON IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL
SINCE THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN. 
 THIS SECURITY HAS NOT BEEN REGISTERED UNDER THE U.S.
SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR THE SECURITIES LAWS OF ANY STATE OR OTHER JURISDICTION. NEITHER THIS SECURITY NOR ANY INTEREST OR PARTICIPATION HEREIN MAY BE RESOLD, PLEDGED OR TRANSFERRED IN THE ABSENCE OF
SUCH REGISTRATION OR UNLESS SUCH TRANSACTION IS EXEMPT FROM, OR NOT SUBJECT TO, SUCH REGISTRATION. THE HOLDER HEREOF, BY PURCHASING THIS SECURITY, AGREES ON ITS OWN BEHALF AND ON BEHALF OF ANY INVESTOR ACCOUNT FOR WHICH IT HAS PURCHASED SECURITIES,
THAT THIS SECURITY OR ANY INTEREST OR PARTICIPATION HEREIN MAY BE OFFERED, RESOLD, PLEDGED OR OTHERWISE TRANSFERRED ONLY (I) TO AMGEN INC. (THE “ISSUER”) OR ANY OF ITS SUBSIDIARIES, (II) SO LONG AS THIS SECURITY IS ELIGIBLE FOR
RESALE PURSUANT TO RULE 144A UNDER THE SECURITIES ACT (“RULE 144A”), TO A PERSON THE SELLER REASONABLY BELIEVES IS A QUALIFIED INSTITUTIONAL BUYER (AS DEFINED IN RULE 144A) IN ACCORDANCE WITH RULE 144A, (III) IN AN OFFSHORE
TRANSACTION TO A NON-U.S. PERSON IN ACCORDANCE WITH RULE 903 OR 904 OF REGULATION S UNDER THE SECURITIES ACT, (IV) PURSUANT TO AN EXEMPTION FROM REGISTRATION PROVIDED BY RULE 144 UNDER THE SECURITIES ACT
(IF AVAILABLE), OR (V) PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT, AND IN EACH OF SUCH CASES IN ACCORDANCE WITH ANY APPLICABLE SECURITIES LAWS OF ANY STATE OF THE UNITED STATES OR OTHER APPLICABLE JURISDICTION. THE
HOLDER HEREOF, BY PURCHASING THIS SECURITY, REPRESENTS AND AGREES THAT IT IS NOT A U.S. PERSON NOR IS IT PURCHASING FOR THE ACCOUNT OF A U.S. PERSON AND IS ACQUIRING THIS SECURITY IN AN OFFSHORE TRANSACTION IN ACCORDANCE WITH REGULATION S UNDER THE
SECURITIES ACT. THE FOREGOING LEGEND MAY BE REMOVED FROM THIS SECURITY ONLY WITH THE CONSENT OF THE ISSUER. 

 Capitalized terms used herein have the meanings assigned to them in the Indenture referred
to below unless otherwise indicated. 
  

	(1)	 INTEREST. Amgen Inc., a Delaware corporation (the “Company”), promises to pay interest on the
principal amount of this Note at 2.770% per annum from August 17, 2020 until maturity. The Company will pay interest in cash semi-annually in arrears on March 1 and September 1 of each year, or if any such day is not a Business Day,
on the next succeeding Business Day (each, an “Interest Payment Date”). Interest on the Notes will accrue from the most recent date to which interest has been paid or, if no interest has been paid, from the date of issuance;
provided that the first Interest Payment Date shall be March 1, 2021; provided further that after March 1, 2021, if there is no existing Default in the payment of interest, and if this Note is authenticated between a record
date referred to on the face hereof and the next succeeding Interest Payment Date, interest shall accrue from such next succeeding Interest Payment Date. The interest rate will be computed on the basis of a
360-day year of twelve 30-day calendar months. 

  

	(2)	 METHOD OF PAYMENT. The Company will pay interest on the Notes (except defaulted interest) to the Persons who
are registered Holders of Notes at the close of business on the day that is 15 days prior to the next succeeding Interest Payment Date (whether or not such day is a Business Day), even if such Notes are canceled after such record date and on or
before such Interest Payment Date, except as provided in Section 2.13 of the Indenture with respect to defaulted interest. The Notes will be payable as to principal and interest at the office or agency of the Company maintained for such purpose
in the Borough of Manhattan, the City and State of New York (or, if the Company fails to maintain such office or agency, at the corporate trust office of the trustee in New York, New York or if the trustee does not maintain an office in New York, at
the office of a paying agent in New York), or, at the option of the Company, payment of interest may be made by check mailed to the Holders at their addresses set forth in the register of Holders; provided that payment by wire transfer of
immediately available funds will be required with respect to principal of and interest on all Global Securities and all other Notes the Holders of which will have provided wire transfer instructions to the Company or the Paying Agent. Such payment
will be in the currency of the United States of America. 

  

	(3)	 PAYING AGENT AND REGISTRAR. Initially, The Bank of New York Mellon Trust Company, N.A., the Trustee under the
Indenture, will act as Paying Agent and Registrar. The Company may change any Paying Agent or Registrar without notice to any Holder. The Company or any of its Subsidiaries may act in any such capacity. 

 

	(4)	 INDENTURE. The terms of the Notes include those stated in the Indenture dated May 22, 2014, between the
Company and the Trustee (the “Indenture”), and those made part of the Indenture by the Officer’s Certificate dated August 17, 2020, delivered pursuant thereto (the “Officer’s Certificate”) and the
TIA. The Notes are subject to all such terms, and the Holders are referred to the Indenture and the TIA for a statement of them. 

  

	(5)	 OPTIONAL REDEMPTION. At any time prior to maturity, the Company will have the option to redeem all or a part of
the Notes upon not less than 10 nor more than 60 days’ notice. If the Notes are redeemed before March 1, 2053 (six months prior to the maturity date of the Notes), the redemption price will equal the sum of (1) 100% of the principal amount
of any Notes being redeemed, plus accrued and unpaid interest to, but not including, the redemption date, and (2) the Make-Whole Amount. If the Notes are redeemed on or after March 1, 2053 (six months prior to the maturity date of the
Notes), the redemption price will equal 100% of the principal amount being redeemed, plus accrued and unpaid interest to, but not including, the redemption date. Unless the Company defaults in the payment of the redemption price, interest will cease
to accrue on the Notes or portions thereof called for redemption on the applicable redemption date. 

	(6)	 NOTICE OF REDEMPTION. Notice of redemption will be mailed at least 10 days but not more than 60 days before the
redemption date to each Holder whose Notes are to be redeemed at its registered address, except that redemption notices may be mailed more than 60 days prior to a redemption date if the notice is issued in connection with a defeasance of the Notes
or a satisfaction or discharge of the Indenture. Notes in denominations larger than $2,000 may be redeemed in part but only in whole multiples of $1,000, unless all of the Notes held by a Holder are to be redeemed. Notices of redemption for the
Notes may be conditional. 

  

	(7)	 MANDATORY REDEMPTION. Except as provided in Section 8 below, the Company is not required to make mandatory
redemption or sinking fund payments with respect to the Notes. 

  

	(8)	 CHANGE OF CONTROL TRIGGERING EVENT. In the event of a Change of Control Triggering Event, the Holders may
require the Company to purchase for cash all or a portion of their Notes at a purchase price equal to 101% of the principal amount of the notes, plus accrued and unpaid interest, if any, pursuant to the provisions of Section 9 of the
Officer’s Certificate. If holders of not less than 90% in aggregate principal amount of the outstanding Notes validly tender and do not withdraw such Notes in a Change Of Control Offer and the Company, or any third party making such an offer in
lieu of the Company, purchases all of the Notes validly tendered and not withdrawn by such holders, the Company or such third party will have the right, upon not less than 10 days nor more than 60 days’ prior notice, provided that such notice
is given not more than 30 days following such repurchase pursuant to the Change Of Control Offer described above, to redeem all Notes that remain outstanding following such purchase on a date specified in such notice (the “Second Change Of
Control Payment Date”) and at a price in cash equal to 101% of the aggregate principal amount of Notes repurchased plus any accrued and unpaid interest on the Notes repurchased to, but not including, the Second Change Of Control Payment
Date. 

  

	(9)	 DEFEASANCE PRIOR TO MATURITY. The Indenture contains provisions for defeasance of (i) the entire
indebtedness of the Notes or (ii) certain covenants and Events of Default with respect to the Notes, in each case upon compliance with certain conditions set forth therein. 

 

	(10)	 RESTRICTIVE COVENANTS. The Indenture and the Officer’s Certificate impose certain limitations on the
Company and its Subsidiaries, including limitations on the Company’s and its Subsidiaries’ ability to create or incur certain Liens on any of their respective properties or assets and to enter into certain sale and lease-back transactions
and on the Company’s ability to engage in mergers or consolidations or the conveyance, transfer or lease of all or substantially all of its properties and assets. These limitations are subject to a number of important qualifications and
exceptions and reference is made to the Indenture and the Officer’s Certificate for a description thereof. 

  

	(11)	 DENOMINATIONS, TRANSFER, EXCHANGE. The Notes are in registered form without coupons in denominations of $2,000
and integral multiples of $1,000. The transfer of Notes may be registered and Notes may be exchanged as provided in the Indenture. The Registrar and the Trustee may require a Holder, among other things, to furnish appropriate endorsements and
transfer documents and the Company may require a Holder to pay any taxes and fees required by law or permitted by the Indenture. The Company need not exchange or register the transfer of any Note or portion of a Note selected for redemption, except
for the unredeemed portion of any Note being redeemed in part. Also, the Company need not exchange or register the transfer of any Notes for a period of 15 days before a selection of Notes to be redeemed or during the period between a record date
and the corresponding Interest Payment Date. 

	(12)	 PERSONS DEEMED OWNERS. The registered Holder of a Note may be treated as its owner for all purposes.

  

	(13)	 AMENDMENT, SUPPLEMENT AND WAIVER. Subject to certain exceptions, the Indenture or the Notes may be amended or
supplemented with the consent of the Holders of at least a majority in aggregate principal amount of the then outstanding Notes voting as a single class, and any existing Default or Event or Default or compliance with any provision of the Indenture
or the Notes may be waived with the consent of the Holders of a majority in aggregate principal amount of the then outstanding Notes voting as a single class. Without the consent of any Holder of a Note, the Indenture or the Notes may be amended or
supplemented to cure any ambiguity, defect or inconsistency; to comply with Article V of the Indenture; to provide for uncertificated Notes in addition to or in place of certificated Notes; to add guarantees with respect to the Notes or secure the
Notes; to surrender any of the Company’s rights or powers under the Indenture; to add covenants or events of default for the benefit of the Holders of the Notes; to comply with the applicable procedures of the applicable depositary; to make any
change that would not adversely affect the rights under the Indenture of any such Holder in any material respect; to provide for the issuance of and establish the form and terms and conditions of Notes of any series as permitted by the Indenture; to
evidence and provide for the acceptance of appointment under the Indenture by a successor trustee with respect to the Notes and to add to or change any of the provisions of the Indenture necessary to provide for the administration of the trusts in
the Indenture by more than one trustee; or to comply with the requirements of the SEC in order to effect or maintain the qualification of the Indenture under the TIA. No amendment to cure any ambiguity, defect or inconsistency in the Indenture made
solely to conform the Indenture to the description of notes contained in the Confidential Offering Circular related to the Notes, dated July 30, 2020, will be deemed to adversely affect the interests of the Holders of the Notes.

  

	(14)	 DEFAULTS AND REMEDIES. If an Event of Default shall occur and be continuing, the principal of the Notes may be
declared (or, in certain cases, shall ipso facto become) due and payable in the manner and with the effect provided in the Indenture. 

  

	(15)	 TRUSTEE DEALINGS WITH COMPANY. The Trustee under the Indenture, in its individual or any other capacity, may
deal with the Company or an Affiliate of the Company with the same rights it would have if it were not Trustee. 

  

	(16)	 NO RECOURSE AGAINST OTHERS. A director, officer, employee or stockholder of the Company shall not have any
liability for any obligations of the Company under the Notes or the Indenture or for any claim based on, in respect of, or by reason of, such obligations or their creation. Each Holder by accepting a Note waives and releases all such liability. The
waiver and release are part of the consideration for the issuance of the Notes. 

  

	(17)	 AUTHENTICATION. This Note will not be valid until authenticated by the manual signature of the Trustee or an
authenticating agent. 

  

	(18)	 ABBREVIATIONS. Customary abbreviations may be used in the name of a Holder or an assignee, such as: TEN COM (=
tenants in common), TEN ENT (= tenants by the entireties), JT TEN (= joint tenants with right of survivorship and not as tenants in common), CUST (= Custodian), and U/G/M/A (= Uniform Gifts to Minors Act). 

 

	(19)	 REGISTRATION RIGHTS OF HOLDERS. In addition to the rights provided to Holders of Notes under the Indenture,
Holders of restricted Notes will have all the rights set forth in the Registration Rights Agreement, dated as of August 17, 2020, between the Company and the dealer managers named on the signature pages thereof (the “Registration Rights
Agreement”). 

	(20)	 CUSIP NUMBERS. Pursuant to a recommendation promulgated by the Committee on Uniform Security Identification
Procedures, the Company has caused CUSIP numbers to be printed on the Notes, and the Trustee may use CUSIP numbers in notices of redemption as a convenience to Holders. No representation is made as to the accuracy of such numbers either as printed
on the Notes or as contained in any notice of redemption, and reliance may be placed only on the other identification numbers placed thereon. 

  

	(21)	 GOVERNING LAW. THE INDENTURE AND THIS NOTE, INCLUDING ANY CLAIM OR CONTROVERSY ARISING OUT OF OR RELATED TO THE
INDENTURE OR THIS NOTE, SHALL BE GOVERNED BY THE LAWS OF THE STATE OF NEW YORK. 

 The Company will furnish to any Holder upon written
request and without charge a copy of the Indenture, the Officer’s Certificate and/or the Registration Rights Agreement. 

Requests may be made to: 

Amgen Inc. 
 One Amgen Center Drive

 Thousand Oaks, CA 91320-1799 

Attention: Investor Relations 

 ASSIGNMENT FORM 

To assign this Note, fill in the form below: 
  

			
	(I) or (we) assign and transfer this Note to:	 	                                      
                                         
                 
		 	    (Insert assignee’s legal name)

  
  

(Insert assignee’s soc. sec. or tax I.D. no.) 
  

 
  

 
  

 
  

 
 (Print or type assignee’s name,
address and zip code) 
 and irrevocably appoint_______________________________________________________________________________ 

to transfer this Note on the books of the Company. The agent may substitute another to act for him. 

Date:  
  

			
	Your Signature:	 	  

		 	(Sign exactly as your name appears on the face of this Note)

 Signature Guarantee*: ___________________ 

 

	*	 Participant in a recognized Signature Guarantee Medallion Program (or other signature guarantor acceptable to
the Trustee).

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