Document:

SYNTHEMED, INC.
                             STOCK OPTION AGREEMENT
                 UNDER THE 2001 NON-QUALIFIED STOCK OPTION PLAN

                          (Non-qualified stock option)

                  AGREEMENT entered into as of the date set forth on the
signature page hereto by and between SyntheMed, Inc., a Delaware corporation,
with a business address of PO Box 219, Little Silver, New Jersey (together with
its subsidiaries, if any, the "Company"), and the undersigned (the "Grantee").

         WHEREAS, the Company desires to grant to the Grantee a non-qualified
stock option under the Company's 2001 Non-Qualified Stock Option Plan (the "2001
Plan") to acquire shares of the Company's Common Stock, $.001 par value (the
"Shares"); and

         WHEREAS, the 2001 Plan provides that each option is to be evidenced by
an option agreement, setting forth the terms and conditions of the option.

         NOW THEREFORE, in consideration of the premises and of the mutual
covenants and agreements contained herein, the Company and the Grantee hereby
agree as follows:

         1. Grant of Option.

         The Company hereby grants to the Grantee a non-qualified stock option
(the "Option") under the 2001 Plan to purchase all or any part of an aggregate
of the number of Shares set forth on the signature page to this Agreement on the
terms and conditions hereinafter set forth. The Option shall NOT be treated as
an incentive stock option under Section 422 of the Internal Revenue Code of
1986, as amended (the "Code").

         2. Purchase Price.

                                                                               1
<PAGE>

         The purchase price ("Purchase Price") for the Shares covered by the
Option shall be the dollar amount per share set forth on the signature page to
this Agreement.

         3. Time of Vesting and Exercise of Option.

                  Subject to Section 4 hereof, the Option shall vest and become
exercisable on the dates and as to the installment amounts set forth on the
signature page to this Agreement. To the extent the Option (or any portion
thereof) is not exercised by the Grantee when it becomes exercisable, it shall
not expire, but shall be carried forward and shall be exercisable, on a
cumulative basis, until the Expiration Date (as hereinafter defined) or until
earlier termination as hereinafter provided.

         4. Term; Extent of Exercisability.

            (a)   Term.

                  (i) The Option shall expire as to each installment amount on
                  the date set forth next to each such amount on the signature
                  page to this Agreement (the "Expiration Date"), subject to
                  earlier termination as herein provided.

                  (ii) In the event a Grantee's employment or service is
                  terminated by the Company for any reason other than
                  "disability", death or for "cause" (collectively, a
                  "Termination without cause"), any Option held by the Grantee
                  shall become one hundred percent vested and fully exercisable
                  for the one year period, except in the case of the first year
                  of an Option's term in which case the exercise period shall be
                  two years, after the date on which the Grantee's employment or
                  service is terminated by the Company, but in any event no
                  later than the date of expiration of the Option term.

                  (iii) In the event the Grantee's employment or service is
                  terminated by the Company for "cause", any Option held by the
                  Grantee shall terminate as of the date the Grantee's
                  employment or service is terminated by the Company and the
                  Grantee shall automatically forfeit all shares underlying any
                  exercised portion of an Option for which the Company has not
                  yet delivered the share certificates, upon refund by the
                  Company of the Exercise Price paid by the Grantee for such
                  shares.

                  (iv) In the event the Grantee's employment or service is
                  terminated by the Company on account of Grantee's
                  "disability", any Option held by the Grantee shall become one
                  hundred percent vested and fully exercisable by the Grantee
                  and shall terminate unless exercised within one year after the
                  date on which the Grantee's employment or service is
                  terminated by the Company, but in any event no later than the
                  date of expiration of the Option term.

                                                                               2
<PAGE>

                  (v) In the event of the death of the Grantee, any Option held
                  by the Grantee shall become one hundred percent vested and
                  fully exercisable by the Grantee and shall terminate unless
                  exercised within then later to occur of one year after the
                  date on which the Grantee's employment or service is
                  terminated by the Company or six months after the probate of
                  the Grantee's estate, but in any event, no later than the date
                  of expiration of the Option term.

                  (vi) In the event a Grantee terminates his or her employment
                  with or services to the Company at his or her own volition,
                  any Option which is otherwise exercisable by the Grantee shall
                  terminate unless exercised within six months, except in the
                  case of the first year of an Option's term in which case the
                  exercise period shall be one year, after the date on which the
                  Grantee's employment with or service to the Company is
                  terminated, but in no event later than the date of expiration
                  of the Option term. Any of the Grantee's Options that are not
                  exercisable as of the date on which the Grantee's employment
                  with or service to the Company is terminated shall terminate
                  as of such date unless the Committee determines otherwise.

                  (vii) Notwithstanding the provisions of Section 4(a)(ii)
                  above, if the Grantee's employment or service is terminated by
                  the Company on account of a "termination without cause" during
                  the one year period following a Change of Control, as such
                  term is defined in the 2001 Plan, any Option held by the
                  Grantee shall become one hundred percent vested and fully
                  exercisable for the two year period after the date on which
                  the Grantee's employment or service is terminated by the
                  Company, but in no event later than the date of expiration of
                  the Option term.

                  (viii) For purposes of this Section 4(a):

                        (A)   The term "Company" shall mean the Company and its
                              parent and subsidiary corporations, or any
                              successor thereto.

                        (B)   The term "disability" shall mean a Grantee's
                              becoming disabled within the meaning of section
                              22(e)(3) of the Code.

                        (C)   The term "termination for cause" shall mean,
                              except to the extent specified otherwise by the
                              Committee that the Grantee has materially breached
                              his or her employment or service contract with the
                              Company, or has been engaged in fraud,
                              embezzlement, theft, commission of a felony in the
                              course of his or her employment or service which
                              is injurious to the Company, or has disclosed
                              trade secrets or confidential
                                                                               3
<PAGE>

                              information of the Company to persons not entitled
                              to receive such information. If this clause (C)
                              conflicts with the definition of "Cause" or
                              "termination for cause" (or any similar
                              definition) in an employment or service agreement
                              between the Company and the Grantee, the terms of
                              the employment or service agreement shall govern.

         5. Manner of Exercise of Option.

            (a) To the extent that the right to exercise the Option has accrued
            and is in effect, the Option may be exercised in full or in part by
            giving written notice to the Company stating the number of Shares as
            to which the Option is being exercised and accompanied by payment in
            full for such Shares. No partial exercise may be made for less than
            one hundred (100) full Shares of Common Stock. Payment shall be made
            in accordance with the terms of the 2001 Plan. Upon such exercise,
            delivery of a certificate for paid-up, non-assessable Shares shall
            be made at the principal office of the Company to the person
            exercising the Option, not less than fifteen (15) and not more than
            forty-five (45) days from the date of receipt of the notice by the
            Company.

            (b) The Company shall at all times during the term of the Option
            reserve and keep available such number of Shares of its Common Stock
            as will be sufficient to satisfy the requirements of the Option.

         6. Non-Transferability.

            Except as provided below, only the Grantee or his or her authorized
representative may exercise rights under an Option. A Grantee may not transfer
options except (i) by will, (ii) by the laws of descent and distribution, (iii)
to the Company (as contemplated by Rule 16b-3 of the Exchange Act, (iv) pursuant
to a domestic relations order (as defined under the Code or Title I of the
Employee Retirement Income Security Act of 1974, as amended, or the regulations
thereunder), or (v) as otherwise permitted by the Committee. When a Grantee
dies, the personal representative or other person entitled to succeed to the
rights of the Grantee ("Successor Grantee") may exercise such rights. A
Successor Grantee must furnish proof satisfactory to the Company of his or her
right to receive the Option under the Grantee's will or under the applicable
laws of descent and distribution.

         7. Representation Letter and Investment Legend.

            In the event that for any reason the Shares to be issued upon
exercise of the Option shall not be effectively registered under the Securities
Act of 1933 (" 1933 Act"), upon any date on which the Option is exercised in
whole or in part, the person exercising the Option shall give a written
representation to the Company in the form attached hereto as Exhibit 1 and the
Company shall place an "investment legend", so-called, as described in Exhibit
1, upon any certificate for the Shares issued by reason of such exercise.

                                                                               4
<PAGE>

         8. Adjustments on Changes in Capitalization.

            Adjustments on changes in capitalization and the like shall be made
in accordance with the 2001 Plan, as in effect on the date of this Option.

         9. No Special Employment Rights.

            The provisions of this Section 9 are applicable only to Grantees who
are employees of the Company. Nothing contained in this Option shall be
construed or deemed by any person under any circumstances to bind the Company to
continue the employment of the Grantee for the period within which this Option
may be exercised. However, during the period of the Grantee's employment, the
Grantee shall render diligently and faithfully the services which are assigned
to the Grantee from time to time by the Board of Directors or by the executive
officers of the Company and shall at no time take any action which directly or
indirectly would be inconsistent with the best interests of the Company.

         10. Rights as a Stockholder.

             The Grantee shall have no rights as a stockholder with respect
to any Shares which may be purchased by exercise of this Option unless and until
a certificate or certificates representing such Shares are duly issued and
delivered to the Grantee.

         11. Withholding Taxes.

             Whenever Shares are to be issued upon exercise of this Option,
the Company shall have the right to require the Grantee to remit to the Company
an amount sufficient to satisfy all Federal, state and local withholding tax
requirements prior to the delivery of any certificate or certificates for the
Shares. The Company may agree to permit the Grantee to authorize the Company to
withhold Shares of Common Stock purchased upon exercise of the Option to satisfy
the above-mentioned withholding requirement; provided, however, no such
agreement may be made by an Grantee who is an officer or director within the
meaning of Section 16 of the Securities Exchange Act of 1934, as amended, except
pursuant to a standing election to so withhold Shares of Common Stock purchased
upon exercise of the Option, such election to be made in the form set forth in
Exhibit 2 hereto and to be made not less than six (6) months prior to such
exercise. Such election may be revoked only upon providing six (6) months prior
written notice to the Company.

                                                                               5
<PAGE>

IN WITNESS WHEREOF, the Company has caused this Agreement to be executed, and
the Grantee has hereunto set his or her hand, all as of the 28th day of May
2004.

                                 SYNTHEMED, INC.

                                 By:    /s/ Richard L. Franklin, MD
                                        ---------------------------
                                 Title: Chairman

                                 GRANTEE

                                 Print Name:   Robert P. Hickey
                                               ---------------------------------

                                 Sign Name:    /s/ Robert P. Hickey
                                               ---------------------------------
                                 Address:
                                               ---------------------------------

                                 -----------------------------------------------

                                 Social Security Number:
                                                        ------------------------

                               OPTION INFORMATION

Total Number of Shares Underlying Option:  500,000
Purchase Price Per Share:  $0.36

                          VESTING & EXPIRATION SCHEDULE

          Vesting Date          Number of Shares        Expiration Date
          ------------          ----------------        ---------------
          April 22, 2005            167,000             April 22, 2012
          April 22, 2006            167,000             April 22, 2013
          April 22, 2007            166,000             April 22, 2014

                                                                               6

<PAGE>

                                    EXHIBIT 1
                            TO STOCK OPTION AGREEMENT
                            -------------------------

Gentlemen:

         In connection with the exercise by me of an option to purchase shares
of Common Stock, $.001 par value, of SyntheMed, Inc. (the "Company"), I hereby
acknowledge that I have been informed as follows:

         1. The shares of Common Stock of the Company to be issued to me
pursuant to the exercise of said option (the "Shares") have not been registered
under the Securities Act of 1933, as amended (the "Securities Act") and,
accordingly, must be held indefinitely unless the Shares are subsequently
registered under the Securities Act, or an exemption from such registration is
available.

         2. Routine sales of securities made in reliance upon Rule 144 under the
Securities Act can be made only after the holding period provided by that Rule
has been satisfied, and, in any sale to which that Rule is not applicable,
registration or compliance with some other exemption under the Securities Act
will be required.

         3. The availability of Rule 144 is dependent upon adequate current
public information with respect to the Company being available and, at the time
that I may desire to make a sale pursuant to the Rule, the Company may neither
wish nor be able to comply with such requirement.

         In consideration of the issuance of certificates for the Shares to me,
I hereby represent and warrant that I am acquiring the Shares for my own account
for investment, and that I will not sell, pledge or transfer the Shares in the
absence of an effective registration statement covering the same, except as
permitted by the provisions of Rule 144, if applicable, or some other applicable
exemption under the Securities Act. In view of this representation and warranty,
I agree that there may be affixed to the certificates for the Shares to be
issued to me, and to all certificates issued hereafter representing the Shares
(until in the opinion of counsel, which opinion must be reasonably satisfactory
in form and substance to counsel for the Company, it is no longer necessary or
required) a legend as follows:

         "The securities represented by this certificate have not been
         registered under the Securities Act of 1933, as amended, and were
         acquired by the registered holder pursuant to a representation and
         warranty that such holder was acquiring the Shares for his own account
         and for investment, with no intention of transfer or disposition of the
         same in violation of the registration requirements of that Act. These
         securities may not be sold, pledged, or transferred in the absence of
         an effective registration statement under such Act, or an opinion of
         counsel, which opinion is reasonably satisfactory to counsel to the
         Company, to the effect that registration is not required under such
         Act."

                                                                               7
<PAGE>

         I further agree that the Company may place a stop transfer order with
its transfer agent, prohibiting the transfer of the Shares, so long as the
legend remains on the certificates representing the Shares.

                                Very truly yours,

Dated: _____________

                                                                               8
<PAGE>

                                    EXHIBIT 2
                            TO STOCK OPTION AGREEMENT
                            -------------------------

Gentlemen:

         The undersigned Grantee hereby elects and agrees that, whenever the
undersigned exercises a stock option (including any options which now or may
hereafter be granted), SyntheMed, Inc. (the "Company") shall withhold from that
exercise such number of Shares equal in value to the federal and state
withholding taxes due upon such exercise. The undersigned further acknowledges
and agrees that this election may not be revoked without six (6) months' prior
written notice to the Company.

                                 GRANTEE:

                                 -----------------------------------------------
                                                   (Signature)

                                 -----------------------------------------------
                                                  (Print Name)

                                                                               9SYNTHEMED, INC.
                             STOCK OPTION AGREEMENT
                 UNDER THE 2001 NON-QUALIFIED STOCK OPTION PLAN

                          (Non-qualified stock option)

                  AGREEMENT entered into as of the date set forth on the
signature page hereto by and between SyntheMed, Inc., a Delaware corporation,
with a business address of PO Box 219, Little Silver, New Jersey (together with
its subsidiaries, if any, the "Company"), and the undersigned (the "Grantee").

         WHEREAS, the Company desires to grant to the Grantee a non-qualified
stock option under the Company's 2001 Non-Qualified Stock Option Plan (the "2001
Plan") to acquire shares of the Company's Common Stock, $.001 par value (the
"Shares"); and

         WHEREAS, the 2001 Plan provides that each option is to be evidenced by
an option agreement, setting forth the terms and conditions of the option.

         NOW THEREFORE, in consideration of the premises and of the mutual
covenants and agreements contained herein, the Company and the Grantee hereby
agree as follows:

         1. Grant of Option.

         The Company hereby grants to the Grantee a non-qualified stock option
(the "Option") under the 2001 Plan to purchase all or any part of an aggregate
of the number of Shares set forth on the signature page to this Agreement on the
terms and conditions hereinafter set forth. The Option shall NOT be treated as
an incentive stock option under Section 422 of the Internal Revenue Code of
1986, as amended (the "Code").

         2. Purchase Price.

                                                                               1
<PAGE>

         The purchase price ("Purchase Price") for the Shares covered by the
Option shall be the dollar amount per share set forth on the signature page to
this Agreement.

         3. Time of Vesting and Exercise of Option.

            Subject to Section 4 hereof, the Option shall vest and become
exercisable on the dates and as to the installment amounts set forth on the
signature page to this Agreement. To the extent the Option (or any portion
thereof) is not exercised by the Grantee when it becomes exercisable, it shall
not expire, but shall be carried forward and shall be exercisable, on a
cumulative basis, until the Expiration Date (as hereinafter defined) or until
earlier termination as hereinafter provided.

         4. Term; Extent of Exercisability.

            (a)   Term.

                  (i) The Option shall expire as to each installment amount on
                  the date set forth next to each such amount on the signature
                  page to this Agreement (the "Expiration Date"), subject to
                  earlier termination as herein provided.

                  (ii) In the event a Grantee's employment or service is
                  terminated by the Company for any reason other than
                  "disability", death or for "cause" (collectively, a
                  "Termination without cause"), any Option held by the Grantee
                  shall become one hundred percent vested and fully exercisable
                  for the one year period, except in the case of the first year
                  of an Option's term in which case the exercise period shall be
                  two years, after the date on which the Grantee's employment or
                  service is terminated by the Company, but in any event no
                  later than the date of expiration of the Option term.

                  (iii) In the event the Grantee's employment or service is
                  terminated by the Company for "cause", any Option held by the
                  Grantee shall terminate as of the date the Grantee's
                  employment or service is terminated by the Company and the
                  Grantee shall automatically forfeit all shares underlying any
                  exercised portion of an Option for which the Company has not
                  yet delivered the share certificates, upon refund by the
                  Company of the Exercise Price paid by the Grantee for such
                  shares.

                  (iv) In the event the Grantee's employment or service is
                  terminated by the Company on account of Grantee's
                  "disability", any Option held by the Grantee shall become one
                  hundred percent vested and fully exercisable by the Grantee
                  and shall terminate unless exercised within one year after the
                  date on which the Grantee's employment or service is
                  terminated by the Company, but in any event no later than the
                  date of expiration of the Option term.

                                                                               2
<PAGE>

                  (v) In the event of the death of the Grantee, any Option held
                  by the Grantee shall become one hundred percent vested and
                  fully exercisable by the Grantee and shall terminate unless
                  exercised within then later to occur of one year after the
                  date on which the Grantee's employment or service is
                  terminated by the Company or six months after the probate of
                  the Grantee's estate, but in any event, no later than the date
                  of expiration of the Option term.

                  (vi) In the event a Grantee terminates his or her employment
                  with or services to the Company at his or her own volition,
                  any Option which is otherwise exercisable by the Grantee shall
                  terminate unless exercised within six months, except in the
                  case of the first year of an Option's term in which case the
                  exercise period shall be one year, after the date on which the
                  Grantee's employment with or service to the Company is
                  terminated, but in no event later than the date of expiration
                  of the Option term. Any of the Grantee's Options that are not
                  exercisable as of the date on which the Grantee's employment
                  with or service to the Company is terminated shall terminate
                  as of such date unless the Committee determines otherwise.

                  (vii) Notwithstanding the provisions of Section 4(a)(ii)
                  above, if the Grantee's employment or service is terminated by
                  the Company on account of a "termination without cause" during
                  the one year period following a Change of Control, as such
                  term is defined in the 2001 Plan, any Option held by the
                  Grantee shall become one hundred percent vested and fully
                  exercisable for the two year period after the date on which
                  the Grantee's employment or service is terminated by the
                  Company, but in no event later than the date of expiration of
                  the Option term.

                  (viii) For purposes of this Section 4(a):

                        (A)   The term "Company" shall mean the Company and its
                              parent and subsidiary corporations, or any
                              successor thereto.

                        (B)   The term "disability" shall mean a Grantee's
                              becoming disabled within the meaning of section
                              22(e)(3) of the Code.

                        (C)   The term "termination for cause" shall mean,
                              except to the extent specified otherwise by the
                              Committee that the Grantee has materially breached
                              his or her employment or service contract with the
                              Company, or has been engaged in fraud,
                              embezzlement, theft, commission of a felony in the
                              course of his or her employment or service which
                              is injurious to the Company, or has disclosed
                              trade secrets or confidential

                                                                               3
<PAGE>

                              information of the Company to persons not entitled
                              to receive such information. If this clause (C)
                              conflicts with the definition of "Cause" or
                              "termination for cause" (or any similar
                              definition) in an employment or service agreement
                              between the Company and the Grantee, the terms of
                              the employment or service agreement shall govern.

         5. Manner of Exercise of Option.

            (a) To the extent that the right to exercise the Option has accrued
            and is in effect, the Option may be exercised in full or in part by
            giving written notice to the Company stating the number of Shares as
            to which the Option is being exercised and accompanied by payment in
            full for such Shares. No partial exercise may be made for less than
            one hundred (100) full Shares of Common Stock. Payment shall be made
            in accordance with the terms of the 2001 Plan. Upon such exercise,
            delivery of a certificate for paid-up, non-assessable Shares shall
            be made at the principal office of the Company to the person
            exercising the Option, not less than fifteen (15) and not more than
            forty-five (45) days from the date of receipt of the notice by the
            Company.

            (b) The Company shall at all times during the term of the Option
            reserve and keep available such number of Shares of its Common Stock
            as will be sufficient to satisfy the requirements of the Option.

         6. Non-Transferability.

            Except as provided below, only the Grantee or his or her authorized
representative may exercise rights under an Option. A Grantee may not transfer
options except (i) by will, (ii) by the laws of descent and distribution, (iii)
to the Company (as contemplated by Rule 16b-3 of the Exchange Act, (iv) pursuant
to a domestic relations order (as defined under the Code or Title I of the
Employee Retirement Income Security Act of 1974, as amended, or the regulations
thereunder), or (v) as otherwise permitted by the Committee. When a Grantee
dies, the personal representative or other person entitled to succeed to the
rights of the Grantee ("Successor Grantee") may exercise such rights. A
Successor Grantee must furnish proof satisfactory to the Company of his or her
right to receive the Option under the Grantee's will or under the applicable
laws of descent and distribution.

         7. Representation Letter and Investment Legend.

            In the event that for any reason the Shares to be issued upon
exercise of the Option shall not be effectively registered under the Securities
Act of 1933 (" 1933 Act"), upon any date on which the Option is exercised in
whole or in part, the person exercising the Option shall give a written
representation to the Company in the form attached hereto as Exhibit 1 and the
Company shall place an "investment legend", so-called, as described in Exhibit
1, upon any certificate for the Shares issued by reason of such exercise.

                                                                               4
<PAGE>

         8. Adjustments on Changes in Capitalization.

            Adjustments on changes in capitalization and the like shall be made
in accordance with the 2001 Plan, as in effect on the date of this Option.

         9. No Special Employment Rights.

            The provisions of this Section 9 are applicable only to Grantees who
are employees of the Company. Nothing contained in this Option shall be
construed or deemed by any person under any circumstances to bind the Company to
continue the employment of the Grantee for the period within which this Option
may be exercised. However, during the period of the Grantee's employment, the
Grantee shall render diligently and faithfully the services which are assigned
to the Grantee from time to time by the Board of Directors or by the executive
officers of the Company and shall at no time take any action which directly or
indirectly would be inconsistent with the best interests of the Company.

         10. Rights as a Stockholder.

             The Grantee shall have no rights as a stockholder with respect to
any Shares which may be purchased by exercise of this Option unless and until a
certificate or certificates representing such Shares are duly issued and
delivered to the Grantee.

         11. Withholding Taxes.

             Whenever Shares are to be issued upon exercise of this Option, the
Company shall have the right to require the Grantee to remit to the Company an
amount sufficient to satisfy all Federal, state and local withholding tax
requirements prior to the delivery of any certificate or certificates for the
Shares. The Company may agree to permit the Grantee to authorize the Company to
withhold Shares of Common Stock purchased upon exercise of the Option to satisfy
the above-mentioned withholding requirement; provided, however, no such
agreement may be made by an Grantee who is an officer or director within the
meaning of Section 16 of the Securities Exchange Act of 1934, as amended, except
pursuant to a standing election to so withhold Shares of Common Stock purchased
upon exercise of the Option, such election to be made in the form set forth in
Exhibit 2 hereto and to be made not less than six (6) months prior to such
exercise. Such election may be revoked only upon providing six (6) months prior
written notice to the Company.

                                                                               5
<PAGE>

IN WITNESS WHEREOF, the Company has caused this Agreement to be executed, and
the Grantee has hereunto set his or her hand, all as of the 28th day of May
2004.

                                  SYNTHEMED, INC.

                                  By:    /s/ Robert P. Hickey
                                         -------------------------------------
                                  Title:  President & CEO

                                  GRANTEE

                                  Print Name:  Eli Pines, PhD
                                               -------------------------------

                                  Sign Name:   /s/ Eli Pines
                                               -------------------------------

                                  Address:
                                               -------------------------------

                                  --------------------------------------------

                                  Social Security Number:
                                                         ---------------------

                               OPTION INFORMATION

Total Number of Shares Underlying Option:  230,000
Purchase Price Per Share:  $0.36

                          VESTING & EXPIRATION SCHEDULE

           Vesting Date         Number of Shares        Expiration Date
           ------------         ----------------        ---------------

          April 22, 2005            77,000              April 22, 2012
          April 22, 2006            77,000              April 22, 2013
          April 22, 2007            76,000              April 22, 2014

                                                                               6

<PAGE>

                                    EXHIBIT 1
                            TO STOCK OPTION AGREEMENT
                            -------------------------
Gentlemen:

         In connection with the exercise by me of an option to purchase shares
of Common Stock, $.001 par value, of SyntheMed, Inc. (the "Company"), I hereby
acknowledge that I have been informed as follows:

         1. The shares of Common Stock of the Company to be issued to me
pursuant to the exercise of said option (the "Shares") have not been registered
under the Securities Act of 1933, as amended (the "Securities Act") and,
accordingly, must be held indefinitely unless the Shares are subsequently
registered under the Securities Act, or an exemption from such registration is
available.

         2. Routine sales of securities made in reliance upon Rule 144 under the
Securities Act can be made only after the holding period provided by that Rule
has been satisfied, and, in any sale to which that Rule is not applicable,
registration or compliance with some other exemption under the Securities Act
will be required.

         3. The availability of Rule 144 is dependent upon adequate current
public information with respect to the Company being available and, at the time
that I may desire to make a sale pursuant to the Rule, the Company may neither
wish nor be able to comply with such requirement.

         In consideration of the issuance of certificates for the Shares to me,
I hereby represent and warrant that I am acquiring the Shares for my own account
for investment, and that I will not sell, pledge or transfer the Shares in the
absence of an effective registration statement covering the same, except as
permitted by the provisions of Rule 144, if applicable, or some other applicable
exemption under the Securities Act. In view of this representation and warranty,
I agree that there may be affixed to the certificates for the Shares to be
issued to me, and to all certificates issued hereafter representing the Shares
(until in the opinion of counsel, which opinion must be reasonably satisfactory
in form and substance to counsel for the Company, it is no longer necessary or
required) a legend as follows:

         "The securities represented by this certificate have not been
         registered under the Securities Act of 1933, as amended, and were
         acquired by the registered holder pursuant to a representation and
         warranty that such holder was acquiring the Shares for his own account
         and for investment, with no intention of transfer or disposition of the
         same in violation of the registration requirements of that Act. These
         securities may not be sold, pledged, or transferred in the absence of
         an effective registration statement under such Act, or an opinion of
         counsel, which opinion is reasonably satisfactory to counsel to the
         Company, to the effect that registration is not required under such
         Act."

                                                                               7
<PAGE>

         I further agree that the Company may place a stop transfer order with
its transfer agent, prohibiting the transfer of the Shares, so long as the
legend remains on the certificates representing the Shares.

                                Very truly yours,

Dated: _____________

                                                                               8
<PAGE>

                                    EXHIBIT 2
                            TO STOCK OPTION AGREEMENT
                            -------------------------

Gentlemen:

         The undersigned Grantee hereby elects and agrees that, whenever the
undersigned exercises a stock option (including any options which now or may
hereafter be granted), SyntheMed, Inc. (the "Company") shall withhold from that
exercise such number of Shares equal in value to the federal and state
withholding taxes due upon such exercise. The undersigned further acknowledges
and agrees that this election may not be revoked without six (6) months' prior
written notice to the Company.

                                    GRANTEE:

                                    --------------------------------------------
                                                     (Signature)

                                    --------------------------------------------
                                                    (Print Name)

                                                                               9

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