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Exhibit 10.02  

 
 

DEXCOM, INC.
  1999 STOCK OPTION PLAN    
    
    As approved by the Board of Directors on August 11, 1999 and amended through December 7, 2004    
    

1.     PURPOSES.  

        (a)   Eligible Option Recipients. The persons eligible to receive Options are the Employees, Directors and Consultants of the
Company and its Affiliates. 

        (b)   Available Options. The purpose of the Plan is to provide a means by which eligible recipients of Options may be given an
opportunity to benefit from increases in value of the Common Stock through the granting of the following Options: (i) Incentive Stock Options and (ii) Nonstatutory Stock Options. 

        (c)   General Purpose. The Company, by means of the Plan, seeks to retain the services of the group of persons eligible to
receive Options, to secure and retain the services of new members of this group and to provide incentives for such persons to exert maximum efforts for the success of the Company and its Affiliates. 

2.     DEFINITIONS.  

        (a)   "Affiliate" means any parent corporation or subsidiary corporation of the Company, whether now or
hereafter existing, as those terms are defined in Sections 424(e) and (f), respectively, of the Code. 

        (b)   "Board" means the Board of Directors of the Company. 

        (c)   "Code" means the Internal Revenue Code of 1986, as amended. 

        (d)   "Committee" means a Committee appointed by the Board in accordance with subsection 3(c). 

        (e)   "Common Stock" means the common stock of the Company. 

        (f)    "Company" means Dexcom, Inc., a Delaware corporation. 

        (g)   "Consultant" means any person, including an advisor, (i) engaged by the Company or an
Affiliate to render consulting or advisory services and who is compensated for such services or (ii) who is a member of the Board of Directors of an Affiliate. However, the term "Consultant"
shall not include either Directors of the Company who are not compensated by the Company for their services as Directors or Directors of the Company who are merely paid a director's fee by the Company
for their services as Directors. 

        (h)   "Continuous Service" means that the Optionholder's service with the Company or an Affiliate,
whether as an Employee, Director or Consultant, is not interrupted or terminated. The Optionholder's Continuous Service shall not be deemed to have terminated merely because of a change in the
capacity in which the Optionholder renders service to the Company or an Affiliate as an Employee, Consultant or Director or a change in the entity for which the Optionholder renders such service,
provided that there is no interruption or termination of the Optionholder's Continuous Service. For example, a change in status from an Employee of the Company to a Consultant of an Affiliate or a
Director of the Company will not constitute an interruption of Continuous Service. The Board or the chief executive officer of the Company, in that party's sole discretion, may determine whether
Continuous Service shall be considered interrupted in the case of any leave of absence approved by that party, including sick leave, military leave or any other personal leave. 

        (i)    "Covered Employee" means the chief executive officer and the four (4) other highest
compensated officers of the Company for whom total compensation is required to be reported to stockholders under the Exchange Act, as determined for purposes of Section 162(m) of the Code. 

 

        (j)    "Director" means a member of the Board of Directors of the Company. 

        (k)   "Disability" means (i) before the Listing Date, the inability of a person, in the opinion
of a qualified physician acceptable to the Company, to perform the major duties of that person's position with the Company or an Affiliate of the Company because of the sickness or injury of the
person and (ii) after the Listing Date, the permanent and total disability of a person within the meaning of Section 22(e)(3) of the Code. 

        (l)    "Employee" means any person employed by the Company or an Affiliate. Mere service as a Director
or payment of a director's fee by the Company or an Affiliate shall not be sufficient to constitute "employment" by the Company or an Affiliate. 

        (m)  "Exchange Act" means the Securities Exchange Act of 1934, as amended. 

        (n)   "Fair Market Value" means, as of any date, the value of the Common Stock determined as follows: 

          (i)  If the Common Stock is listed on any established stock exchange or traded on the Nasdaq National Market or the Nasdaq
SmallCap Market, the Fair Market Value of a share of Common Stock shall be the closing sales price for such stock (or the closing bid, if no sales were reported) as quoted on such exchange or market
(or the exchange or market with the greatest volume of trading in the Common Stock) on the last market trading day prior to the day of determination, as reported in The Wall
Street Journal or such other source as the Board deems reliable. 

         (ii)  In the absence of such markets for the Common Stock, the Fair Market Value shall be determined in good faith by the
Board. 

       (iii)  Prior to the Listing Date, the value of the Common Stock shall be determined in a manner consistent with
Section 260.140.50 of Title 10 of the California Code of Regulations. 

        (o)   "Incentive Stock Option" means an Option intended to qualify as an incentive stock option within
the meaning of Section 422 of the Code and the regulations promulgated thereunder. 

        (p)   "Listing Date" means the first date upon which any security of the Company is listed (or approved
for listing) upon notice of issuance on any securities exchange or designated (or approved for designation) upon notice of issuance as a national market security on an interdealer quotation system if
such securities exchange or interdealer quotation system has been certified in accordance with the provisions of Section 25100(o) of the California Corporate Securities Law of 1968. 

        (q)   "Non-Employee Director" means a Director of the Company who either (i) is not
a current Employee or Officer of the Company or its parent or a subsidiary, does not receive compensation (directly or indirectly) from the Company or its parent or a subsidiary for services rendered
as a consultant or in any capacity other than as a Director (except for an amount as to which disclosure would not be required under Item 404(a) of Regulation S-K promulgated
pursuant to the Securities Act ("Regulation S-K")), does not possess an interest in any other transaction as to which disclosure would be required under Item 404(a) of
Regulation S-K and is not engaged in a business relationship as to which disclosure would be required under Item 404(b) of Regulation S-K; or (ii) is
otherwise considered a "non-employee director" for purposes of Rule 16b-3. 

        (r)   "Nonstatutory Stock Option" means an Option not intended to qualify as an Incentive Stock Option. 

        (s)   "Officer" means (i) before the Listing Date, any person designated by the Company as an
officer and (ii) on and after the Listing Date, a person who is an officer of the Company within the meaning of Section 16 of the Exchange Act and the rules and regulations promulgated
thereunder. 

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        (t)    "Option" means an Incentive Stock Option or a Nonstatutory Stock Option granted pursuant to the
Plan. 

        (u)   "Option Agreement" means a written agreement between the Company and an Optionholder evidencing
the terms and conditions of an individual Option grant. Each Option Agreement shall be subject to the terms and conditions of the Plan. 

        (v)   "Optionholder" means a person to whom an Option is granted pursuant to the Plan or, if
applicable, such other person who holds an outstanding Option. 

        (w)  "Outside Director" means a Director of the Company who either (i) is not a current
employee of the Company or an "affiliated corporation" (within the meaning of Treasury Regulations promulgated under Section 162(m) of the Code), is not a former employee of the Company or an
"affiliated corporation" receiving compensation for prior services (other than benefits under a tax qualified pension plan), was not an officer of the Company or an "affiliated corporation" at any
time and is not currently receiving direct or indirect remuneration from the Company or an "affiliated corporation" for services in any capacity other than as a Director or (ii) is otherwise
considered an "outside director" for purposes of Section 162(m) of the Code. 

        (x)   "Plan" means this DexCom, Inc. 1999 Stock Option Plan. 

        (y)   "Rule 16b-3" means Rule 16b-3 promulgated under the
Exchange Act or any successor to Rule 16b-3, as in effect from time to time. 

        (z)   "Securities Act" means the Securities Act of 1933, as amended. 

        (aa) "Ten Percent Stockholder" means a person who owns (or is deemed to own pursuant to
Section 424(d) of the Code) stock possessing more than ten percent (10%) of the total combined voting power of all classes of stock of the Company or of any of its Affiliates. 

3.     ADMINISTRATION.  

        (a)   Administration by Board. The Board shall administer the Plan unless and until the Board delegates administration to a
Committee, as provided in subsection 3(c). 

        (b)   Powers of Board. The Board shall have the power, subject to, and within the limitations of, the express provisions of the
Plan: 

          (i)  To determine from time to time which of the persons eligible under the Plan shall be granted Options; when and how each
Option shall be granted; what type of Option shall be granted; the provisions of each Option granted (which need not be identical), including the time or times when a person shall be permitted to
receive stock pursuant to an Option; and the number of shares with respect to which an Option shall be granted to each such person. 

         (ii)  To construe and interpret the Plan and Options granted under it, and to establish, amend and revoke rules and
regulations for its administration. The Board, in the exercise of this power, may correct any defect, omission or inconsistency in the Plan or in any Option Agreement, in a manner and to the extent it
shall deem necessary or expedient to make the Plan fully effective. 

       (iii)  To amend the Plan or an Option as provided in Section 11. 

        (iv)  Generally, to exercise such powers and to perform such acts as the Board deems necessary or expedient to promote the
best interests of the Company which are not in conflict with the provisions of the Plan. 

        (c)   Delegation to Committee. 

          (i)  General. The Board may delegate administration of the Plan to a Committee or Committees of one or more members of the
Board, and the term "Committee" shall apply to any 

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person
or persons to whom such authority has been delegated. If administration is delegated to a Committee, the Committee shall have, in connection with the administration of the Plan, the powers
theretofore possessed by the Board, including the power to delegate to a subcommittee any of the administrative powers the Committee is authorized to exercise (and references in this Plan to the Board
shall thereafter be to the Committee or subcommittee), subject, however, to such resolutions, not inconsistent with the provisions of the Plan, as may be adopted from time to time by the Board. The
Board may abolish the Committee at any time and revest in the Board the administration of the Plan. 

         (ii)  Committee Composition when Common Stock is Publicly Traded. At such time as the Common Stock is publicly traded, in the
discretion of the Board, a Committee may consist solely of two or more Outside Directors, in accordance with Section 162(m) of the Code, and/or solely of two or more
Non-Employee Directors, in accordance with Rule 16b-3. Within the scope of such authority, the Board or the Committee may (i) delegate to a committee of one or
more members of the Board who are not Outside Directors the authority to grant Options to eligible persons who are either (1) not then Covered Employees and are not expected to be Covered
Employees at the time of recognition of income resulting from such Option or (2) not persons with respect to whom the Company wishes to comply with Section 162(m) of the Code
and/or) (ii) delegate to a committee of one or more members of the Board who are not Non-Employee Directors the authority to grant Options to eligible persons who are not then
subject to Section 16 of the Exchange Act. 

4.     SHARES SUBJECT TO THE PLAN.  

        (a)   Share Reserve. Subject to the provisions of Section 10 relating to adjustments upon changes in stock, the stock
that may be issued pursuant to Options shall not exceed in the aggregate Ten Million Seventy-Five Thousand Five Hundred Twenty-Two (10,075,522) shares of Common Stock. 

        (b)   Reversion of Shares to the Share Reserve. If any Option shall for any reason expire or otherwise terminate, in whole or
in part, without having been exercised in full, the stock not acquired under such Option shall revert to and again become available for issuance under the Plan. If any Common Stock acquired pursuant
to the exercise of an Option shall for any reason be repurchased by the Company under an unvested share repurchase option provided under the Plan, the stock repurchased by the Company under such
repurchase option shall not revert to and again become available for issuance under the Plan. 

        (c)   Source of Shares. The stock subject to the Plan may be unissued shares or reacquired shares, bought on the market or
otherwise. 

        (d)   Share Reserve Limitation. Prior to the Listing Date, at no time shall the total number of shares issuable upon exercise
of all outstanding Options and the total number of shares provided for under any stock bonus or similar plan of the Company exceed the applicable percentage as calculated in accordance with the
conditions and exclusions of Section 260.140.45 of Title 10 of the California Code of Regulations, based on the shares of the Company which are outstanding at the time the calculation is made. 

5.     ELIGIBILITY.  

        (a)   Eligibility for Specific Options. Incentive Stock Options may be granted only to Employees. Nonstatutory Stock Options
may be granted to Employees, Directors and Consultants. 

        (b)   Ten Percent Stockholders. No Ten Percent Stockholder shall be eligible for the grant of an Incentive Stock Option unless
the exercise price of such Option is at least one hundred ten percent 

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(110%)
of the Fair Market Value of the Common Stock at the date of grant and the Option is not exercisable after the expiration of five (5) years from the date of grant. 

        Prior
to the Listing Date, no Ten Percent Stockholder shall be eligible for the grant of a Nonstatutory Stock Option unless the exercise price of such Option is at least one hundred ten
percent (110%) of the Fair Market Value of the Common Stock at the date of grant 

        (c)   Section 162(m) Limitation. Subject to the provisions of Section 10 relating to adjustments upon changes in
stock, no employee shall be eligible to be granted Options covering more than two hundred fifty thousand (250,000) shares of the Common Stock during any calendar year. This subsection 5(c) shall not
apply prior to the Listing Date and, following the Listing Date, this subsection 5(c) shall not apply until (i) the earliest of: (1) the first material modification of the Plan
(including any increase in the number of shares reserved for issuance under the Plan in accordance with Section 4); (2) the issuance of all of the shares of Common Stock reserved for
issuance under the Plan; (3) the expiration of the Plan; or (4) the first meeting of stockholders at which Directors of the Company are to be elected that occurs after the close of the
third calendar year following the calendar year in which occurred the first registration of an equity security under Section 12 of the Exchange Act; or (ii) such other date required by
Section 162(m) of the Code and the rules and regulations promulgated thereunder. 

6.     OPTION PROVISIONS.  

        Each Option shall be in such form and shall contain such terms and conditions as the Board shall deem appropriate. All Options shall be separately designated
Incentive Stock Options or Nonstatutory Stock Options at the time of grant, and a separate certificate or certificates will be issued for shares purchased on exercise of each type of Option. The
provisions of separate Options need not be identical, but each Option shall include (through incorporation of provisions hereof by reference in the Option or otherwise) the substance of each of the
following provisions: 

        (a)   Term. Subject to the provisions of subsection 5(b) regarding Ten Percent Stockholders, no Option shall be exercisable
after the expiration of ten (10) years from the date it was granted. 

        (b)   Exercise Price of an Incentive Stock Option. Subject to the provisions of subsection 5(b) regarding Ten Percent
Stockholders, the exercise price of each Incentive Stock Option shall be not less than one hundred percent (100%) of the Fair Market Value of the stock subject to the Option on the date the Option is
granted. Notwithstanding the foregoing, an Incentive Stock Option may be granted with an exercise price lower than that set forth in the preceding sentence if such Option is granted pursuant to an
assumption or substitution for another option in a manner satisfying the provisions of Section 424(a) of the Code. 

        (c)   Exercise Price of a Nonstatutory Stock Option. Subject to the provisions of subsection 5(b) regarding Ten Percent
Stockholders, the exercise price of each Nonstatutory Stock Option granted prior to the Listing Date shall be not less than eighty-five percent (85%) of the Fair Market Value of the stock
subject to the Option on the date the Option is granted. The exercise price of each Nonstatutory Stock Option granted on or after the Listing Date shall be not less than eighty-five
percent (85%) of the Fair Market Value of the stock subject to the Option on the date the Option is granted. Notwithstanding the foregoing, a Nonstatutory Stock Option may be granted with an exercise
price lower than that set forth in the preceding sentence if such Option is granted pursuant to an assumption or substitution for another option in a manner satisfying the provisions of
Section 424(a) of the Code. 

        (d)   Consideration. The purchase price of stock acquired pursuant to an Option shall be paid, to the extent permitted by
applicable statutes and regulations, either (i) in cash at the time the Option is exercised or (ii) at the discretion of the Board at the time of the grant of the Option (or subsequently
in the case of a Nonstatutory Stock Option) by (1) delivery to the Company of other Common Stock, 

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(2) according
to a deferred payment or other arrangement (which may include, without limiting the generality of the foregoing, the use of other Common Stock) with the Optionholder or
(3) in any other form of legal consideration that may be acceptable to the Board; provided, however, that at any time that the Company is incorporated in Delaware, payment of the Common Stock's
"par value," as defined in the Delaware General Corporation Law, shall not be made by deferred payment. 

        In
the case of any deferred payment arrangement, interest shall be compounded at least annually and shall be charged at the minimum rate of interest necessary to avoid the treatment as
interest, under any applicable provisions of the Code, of any amounts other than amounts stated to be interest under the deferred payment arrangement. 

        (e)   Transferability of an Incentive Stock Option. An Incentive Stock Option shall not be transferable except by will or by
the laws of descent and distribution and shall be exercisable during the lifetime of the Optionholder only by the Optionholder. Notwithstanding the foregoing provisions of this subsection 6(e), the
Optionholder may, by delivering written notice to the Company, in a form satisfactory to the Company, designate a third party who, in the event of the death of the Optionholder, shall thereafter be
entitled to exercise the Option. 

        (f)    Transferability of a Nonstatutory Stock Option. A Nonstatutory Stock Option granted prior to the Listing Date shall not
be transferable except by will or by the laws of descent and distribution and shall be exercisable during the lifetime of the Optionholder only by the Optionholder. A Nonstatutory Stock Option granted
on or after the Listing Date shall be transferable to the extent provided in the Option Agreement. If the Nonstatutory Stock Option does not provide for transferability, then the Nonstatutory Stock
Option shall not be transferable except by will or by the laws of descent and distribution and shall be exercisable during the lifetime of the Optionholder only by the Optionholder. Notwithstanding
the foregoing provisions of this subsection 6(f), the Optionholder may, by delivering written notice to the Company, in a form satisfactory to the Company, designate a third party who, in the event of
the death of the Optionholder, shall thereafter be entitled to exercise the Option. 

        (g)   Vesting Generally. The total number of shares of Common Stock subject to an Option may, but need not, vest and therefore
become exercisable in periodic installments which may, but need not, be equal. The Option may be subject to such other terms and conditions on the time or times when it may be exercised (which may be
based on performance or other criteria) as the Board may deem appropriate. The vesting provisions of individual Options may vary. The provisions of this subsection 6(g) are subject to any Option
provisions governing the minimum number of shares as to which an Option may be exercised. 

        (h)   Minimum Vesting Prior to the Listing Date. Notwithstanding the foregoing subsection 6(g), Options granted prior to the
Listing Date shall provide for vesting of the total number of shares at a rate of at least twenty percent (20%) per year over five (5) years from the date the Option was granted, subject to
reasonable conditions such as continued employment. However, in the case of such Options granted to Officers, Directors or Consultants, the Option may become fully exercisable, subject to reasonable
conditions such as continued employment, at any time or during any period established by the Company; for example, the vesting provision of the Option may provide for vesting of less than twenty
percent (20%) per year of the total number of shares subject to the Option. 

        (i)    Termination of Continuous Service. In the event an Optionholder's Continuous Service terminates (other than upon the
Optionholder's death or Disability), the Optionholder may exercise his or her Option (to the extent that the Optionholder was entitled to exercise it as of the date of termination) but only within
such period of time ending on the earlier of (i) the date three (3) months following the termination of the Optionholder's Continuous Service (or such longer or shorter period specified
in the Option Agreement, which, for Options granted prior to the Listing Date, shall not be less than thirty (30) days, unless such termination is for cause), or (ii) the expiration of
the term of the 

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Option
as set forth in the Option Agreement. If, after termination, the Optionholder does not exercise his or her Option within the time specified in the Option Agreement, the Option shall terminate. 

        (j)    Extension of Termination Date. An Optionholder's Option Agreement may also provide that if the exercise of the Option
following the termination of the Optionholder's Continuous Service (other than upon the Optionholder's death or Disability) would be prohibited at any time solely because the issuance of shares would
violate the registration requirements under the Securities Act, then the Option shall terminate on the earlier of (i) the expiration of the term of the Option set forth in subsection 6(a) or
(ii) the expiration of a period of three (3) months after the termination of the Optionholder's Continuous Service during which the exercise of the Option would not be in violation of
such registration requirements. 

        (k)   Disability of Optionholder. In the event an Optionholder's Continuous Service terminates as a result of the
Optionholder's Disability, the Optionholder may exercise his or her Option (to the extent that the Optionholder was entitled to exercise it as of the date of termination), but only within such period
of time ending on the earlier of (i) the date twelve (12) months following such termination (or such longer or shorter period specified in the Option Agreement, which, for Options
granted prior to the Listing Date, shall not be less than six (6) months) or (ii) the expiration of the term of the Option as set forth in the Option Agreement. If, after termination,
the Optionholder does not exercise his or her Option within the time specified herein, the Option shall terminate. 

        (l)    Death of Optionholder. In the event (i) an Optionholder's Continuous Service terminates as a result of the
Optionholder's death or (ii) the Optionholder dies within the period (if any) specified in the Option Agreement after the termination of the Optionholder's Continuous Service for a reason other
than death, then the Option may be exercised (to the extent the Optionholder was entitled to exercise the Option as of the date of death) by the Optionholder's estate, by a person who acquired the
right to exercise the Option by bequest or inheritance or by a person designated to exercise the option upon the Optionholder's death pursuant to subsection 6(e) or 6(f), but only within the period
ending on the earlier of (1) the date eighteen (18) months following the date of death (or such longer or shorter period specified in the Option Agreement, which, for Options granted
prior to the Listing Date, shall not be less than six (6) months) or (2) the expiration of the term of such Option as set forth in the Option Agreement. If, after death, the Option is
not exercised within the time specified herein, the Option shall terminate. 

        (m)  Early Exercise. The Option may, but need not, include a provision whereby the Optionholder may elect at any time before
the Optionholder's Continuous Service terminates to exercise the Option as to any part or all of the shares subject to the Option prior to the full vesting of the Option. Subject to the "Repurchase
Limitation" in subsection 9(h), any unvested shares so purchased may be subject to an unvested share repurchase option in favor of the Company or to any other restriction the Board determines to be
appropriate. 

        (n)   Right of Repurchase. Subject to the "Repurchase Limitation" in subsection 9(h), the Option may, but need not, include a
provision whereby the Company may elect, prior to the Listing Date, to repurchase all or any part of the vested shares acquired by the Optionholder pursuant to the exercise of the Option. 

        (o)   Right of First Refusal. The Option may, but need not, include a provision whereby the Company may elect, prior to the
Listing Date, to exercise a right of first refusal following receipt of notice from the Optionholder of the intent to transfer all or any part of the shares exercised pursuant to the Option. Except as
expressly provided in this subsection 6(o), such right of first refusal shall otherwise comply with any applicable provisions of the Bylaws of the Company. 

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        (p)   Re-Load Options. Without in any way limiting the authority of the Board to make or not to make grants of
Options hereunder, the Board shall have the authority (but not an obligation) to include as part of any Option Agreement a provision entitling the Optionholder to a further Option (a
"Re-Load Option") in the event the Optionholder exercises the Option evidenced by the Option Agreement, in whole or in part, by surrendering other shares of Common Stock in accordance with
this Plan and the terms and conditions of the Option Agreement. Any such Re-Load Option shall (i) provide for a number of shares equal to the number of shares surrendered as part or
all of the exercise price of such Option; (ii) have an expiration date which is the same as the expiration date of the Option the exercise of which gave rise to such Re-Load Option;
and (iii) have an exercise price which is equal to one hundred percent (100%) of the Fair Market Value of the Common Stock subject to the Re-Load Option on the date of exercise of
the original Option. Notwithstanding the foregoing, a Re-Load Option shall be subject to the same exercise price and term provisions heretofore described for Options under the Plan. 

        Any
such Re-Load Option may be an Incentive Stock Option or a Nonstatutory Stock Option, as the Board may designate at the time of the grant of the original Option; provided,
however, that the designation of any Re-Load Option as an Incentive Stock Option shall be subject to the one hundred thousand dollars ($100,000) annual limitation on exercisability of
Incentive Stock Options described in subsection 9(d) and in Section 422(d) of the Code. There shall be no Re-Load Options on a Re-Load Option. Any such
Re-Load Option shall be subject to the availability of sufficient shares under subsection 4(a) and the "Section 162(m) Limitation" on the grants of Options under subsection 5(c) and
shall be subject to such other terms and conditions as the Board may determine which are not inconsistent with the express provisions of the Plan regarding the terms of Options. 

7.     COVENANTS OF THE COMPANY.  

        (a)   Availability of Shares. During the terms of the Options, the Company shall keep available at all times the number of
shares of Common Stock required to satisfy such Options. 

        (b)   Securities Law Compliance. The Company shall seek to obtain from each regulatory commission or agency having jurisdiction
over the Plan such authority as may be required to grant Options and to issue and sell shares of Common Stock upon exercise of the Options; provided, however, that this undertaking shall not require
the Company to register under the Securities Act the Plan, any Option or any stock issued or issuable pursuant to any such Option. If, after reasonable efforts, the Company is unable to obtain from
any such regulatory commission or agency the authority which counsel for the Company deems necessary for the lawful issuance and sale of stock under the Plan, the Company shall be relieved from any
liability for failure to issue and sell stock upon exercise of such Options unless and until such authority is obtained. 

8.     USE OF PROCEEDS FROM STOCK.  

        (a)   Proceeds from the sale of stock pursuant to Options shall constitute general funds of the Company. 

9.     MISCELLANEOUS.  

        (a)   Acceleration of Exercisability and Vesting. The Board shall have the power to accelerate the time at which an Option may
first be exercised or the time during which an Option or any part thereof will vest in accordance with the Plan, notwithstanding the provisions in the Option stating the time at which it may first be
exercised or the time during which it will vest. 

        (b)   Stockholder Rights. No Optionholder shall be deemed to be the holder of, or to have any of the rights of a holder with
respect to, any shares subject to such Option unless and until such Optionholder has satisfied all requirements for exercise of the Option pursuant to its terms. 

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        (c)   No Employment or other Service Rights. Nothing in the Plan or any instrument executed or Option granted pursuant thereto
shall confer upon any Optionholder any right to continue to serve the Company or an Affiliate in the capacity in effect at the time the Option was granted or shall affect the right of the Company or
an Affiliate to terminate (i) the employment of an Employee with or without notice and with or without cause, (ii) the service of a Consultant pursuant to the terms of such Consultant's
agreement with the Company or an Affiliate or (iii) the service of a Director pursuant to the Bylaws of the Company or an Affiliate, and any applicable provisions of the corporate law of the
state in which the Company or the Affiliate is incorporated, as the case may be. 

        (d)   Incentive Stock Option $100,000 Limitation. To the extent that the aggregate Fair Market Value (determined at the time of
grant) of stock with respect to which Incentive Stock Options are exercisable for the first time by any Optionholder during any calendar year (under all plans of the Company and its Affiliates)
exceeds one hundred thousand dollars ($100,000), the Options or portions thereof which exceed such limit (according to the order in which they were granted) shall be treated as Nonstatutory Stock
Options. 

        (e)   Investment Assurances. The Company may require an Optionholder, as a condition of exercising or acquiring stock under any
Option, (i) to give written assurances satisfactory to the Company as to the Optionholder's knowledge and experience in financial and business matters and/or to employ a purchaser
representative reasonably satisfactory to the Company who is knowledgeable and experienced in financial and business matters and that he or she is capable of evaluating, alone or together with the
purchaser representative, the merits and risks of exercising the Option; and (ii) to give written assurances satisfactory to the Company stating that the Optionholder is acquiring the stock
subject to the Option for the Optionholder's own account and not with any present intention of selling or otherwise distributing the stock. The foregoing requirements, and any assurances given
pursuant to such requirements, shall be inoperative if (iii) the issuance of the shares upon the exercise or acquisition of stock under the Option has been registered under a then currently
effective registration statement under the Securities Act or (iv) as to any particular requirement, a determination is made by counsel for the Company that such requirement need not be met in
the circumstances under the then applicable securities laws. The Company may, upon advice of counsel to the Company, place legends on stock certificates issued under the Plan as such counsel deems
necessary or appropriate in order to comply with applicable securities laws, including, but not limited to, legends restricting the transfer of the stock. 

        (f)    Withholding Obligations. To the extent provided by the terms of an Option Agreement, the Optionholder may satisfy any
federal, state or local tax withholding obligation relating to the exercise or acquisition of stock under an Option by any of the following means (in addition to the Company's right to withhold from
any compensation paid to the Optionholder by the Company) or by a combination of such means: (i) tendering a cash payment; (ii) authorizing the Company to withhold shares from the shares
of the Common Stock otherwise issuable to the Optionholder as a result of the exercise or acquisition of stock under the Option; or (iii) delivering to the Company owned and unencumbered shares
of the Common Stock. 

        (g)   Information Obligation. Prior to the Listing Date, to the extent required by Section 260.140.46 of Title 10 of the
California Code of Regulations, the Company shall deliver financial statements to Optionholders at least annually. This subsection 9(g) shall not apply to key Employees whose duties in connection with
the Company assure them access to equivalent information. 

        (h)   Repurchase Limitation. The terms of any repurchase option shall be specified in the Option and may be either at Fair
Market Value at the time of repurchase or at not less than the original purchase price. To the extent required by Section 260.140.41 and Section 260.140.42 of Title 10 of the California
Code of Regulations, any repurchase option contained in an Option granted prior to the 

9

 

Listing
Date to a person who is not an Officer, Director or Consultant shall be upon the terms described below: 

          (i)  Fair Market Value. If the repurchase option gives the Company the right to repurchase the shares upon termination of
employment at not less than the Fair Market Value of the shares to be purchased on the date of termination of Continuous Service, then (i) the right to repurchase shall be exercised for cash or
cancellation of purchase money indebtedness for the shares within ninety (90) days of termination of Continuous Service (or in the case of shares issued upon exercise of Options after such date
of termination, within ninety (90) days after the date of the exercise) or such longer period as may be agreed to by the Company and the Optionholder (for example, for purposes of satisfying
the requirements of Section 1202(c)(3) of the Code regarding "qualified small business stock") and (ii) the right terminates when the shares become publicly traded. 

         (ii)  Original Purchase Price. If the repurchase option gives the Company the right to repurchase the shares upon termination
of Continuous Service at the original purchase price, then (i) the right to repurchase at the original purchase price shall lapse at the rate of least twenty percent (20%) of the shares per
year over five (5) years from the date the Option is granted (without respect to the date the Option was exercised or became exercisable) and (ii) the right to repurchase shall be
exercised for cash or cancellation of purchase money indebtedness for the shares within ninety (90) days of termination of Continuous Service (or in the case of shares issued upon exercise of
Options after such date of termination, within ninety (90) days after the date of the exercise) or such longer period as may be agreed to by the Company and the Optionholder (for example, for
purposes of satisfying the requirements of Section 1202(c)(3) the Code regarding "qualified small business stock"). 

10.   ADJUSTMENTS UPON CHANGES IN STOCK.  

        (a)   Capitalization Adjustments. If any change is made in the stock subject to the Plan, or subject to any Option, without the
receipt of consideration by the Company (through merger, consolidation, reorganization, recapitalization, reincorporation, stock dividend, dividend in property other than cash, stock split,
liquidating dividend, combination of shares, exchange of shares, change in corporate structure or other transaction not involving the receipt of consideration by the Company), the Plan will be
appropriately adjusted in the class(es) and maximum number of securities subject to the Plan pursuant to subsection 4(a) and the maximum number of securities subject to award to any person pursuant to
subsection 5(c), and the outstanding Options will be appropriately adjusted in the class(es) and number of securities and price per share of stock subject to such outstanding Options. The Board, the
determination of which shall be final, binding and conclusive, shall make such adjustments. (The conversion of any convertible securities of the Company shall not be treated as a transaction "without
receipt of consideration" by the Company.) 

        (b)   Change in Control—Dissolution or Liquidation. In the event of a dissolution or liquidation of the Company,
then such Options shall be terminated if not exercised (if applicable) prior to such event. 

        (c)   Change in Control—Asset Sale, Merger, Consolidation or Reverse Merger. In the event of (i) a sale of
substantially all of the assets of the Company, (ii) a merger or consolidation in which the Company is not the surviving corporation or (iii) a reverse merger in which the Company is the
surviving corporation but the shares of Common Stock outstanding immediately preceding the merger are converted by virtue of the merger into other property, whether in the form of securities, cash or
otherwise, then any surviving corporation or acquiring corporation shall assume any Options outstanding under the Plan or shall substitute similar Options (including an option to acquire the same
consideration paid to the stockholders in the transaction described in this subsection 10(c) for those outstanding under the Plan. In the event any surviving corporation or acquiring corporation
refuses to 

10

 

assume
such Options or to substitute similar Options for those outstanding under the Plan, then with respect to Options held by Optionholders whose Continuous Service has not terminated, the vesting
of such Options shall be accelerated in full, and the Options shall terminate if not exercised at or prior to such event. With respect to any other Options outstanding under the Plan, such Options
shall terminate if not exercised prior to such event. 

11.   AMENDMENT OF THE PLAN AND OPTIONS.  

        (a)   Amendment of Plan. The Board at any time, and from time to time, may amend the Plan. However, except as provided in
Section 10 relating to adjustments upon changes in stock, no amendment shall be effective unless approved by the stockholders of the Company to the extent stockholder approval is necessary to
satisfy the requirements of Section 422 of the Code, Rule 16b-3 or any Nasdaq or securities exchange listing requirements. 

        (b)   Stockholder Approval. The Board may, in its sole discretion, submit any other amendment to the Plan for stockholder
approval, including, but not limited to, amendments to Plan intended to satisfy the requirements of Section 162(m) of the Code and the regulations thereunder regarding the exclusion of
performance-based compensation from the limit on corporate deductibility of compensation paid to certain executive officers. 

        (c)   Contemplated Amendments. It is expressly contemplated that the Board may amend the Plan in any respect the Board deems
necessary or advisable to provide eligible Employees with the maximum benefits provided or to be provided under the provisions of the Code and the regulations promulgated thereunder relating to
Incentive Stock Options and/or to bring the Plan and/or Incentive Stock Options granted under it into compliance therewith. 

        (d)   No Impairment of Rights. Rights under any Option granted before amendment of the Plan shall not be impaired by any
amendment of the Plan unless (i) the Company requests the consent of the Optionholder and (ii) the Optionholder consents in writing. 

        (e)   Amendment of Options. The Board at any time, and from time to time, may amend the terms of any one or more Options;
provided, however, that the rights under any Option shall not be impaired by any such amendment unless (i) the Company requests the consent of the Optionholder and (ii) the Optionholder
consents in writing. 

12.   TERMINATION OR SUSPENSION OF THE PLAN.  

        (a)   Plan Term. The Board may suspend or terminate the Plan at any time. Unless sooner terminated, the Plan shall terminate on
the day before the tenth (10th) anniversary of the date the Plan is adopted by the Board or approved by the stockholders of the Company, whichever is earlier. No Options may be granted under the Plan
while the Plan is suspended or after it is terminated. 

        (b)   No Impairment of Rights. Suspension or termination of the Plan shall not impair rights and obligations under any Option
granted while the Plan is in effect except with the written consent of the Optionholder. 

13.   EFFECTIVE DATE OF PLAN.  

        The Plan shall become effective as determined by the Board, but no Option shall be exercised unless and until the Plan has been approved by the stockholders of
the Company, which approval shall be within twelve (12) months before or after the date the Plan is adopted by the Board. 

11

 
 

ATTACHMENT I    
    
    STOCK OPTION AGREEMENT    
    

  

 
 

DEXCOM, INC.
  1999 STOCK OPTION PLAN    
    
    STOCK OPTION AGREEMENT
  (INCENTIVE AND NONSTATUTORY STOCK OPTIONS)    
    

        Pursuant to your Stock Option Grant Notice ("Grant Notice") and this Stock Option Agreement, Dexcom, Inc. (the "Company") has granted you an option under
its 1999 Stock Option Plan (the "Plan") to purchase the number of shares of the Company's Common Stock indicated in your Grant Notice at the exercise price indicated in your Grant Notice. Defined
terms not explicitly defined in this Stock Option Agreement but defined in the Plan shall have the same definitions as in the Plan. 

        The
details of your option are as follows: 

        1.    VESTING.    Subject to the limitations contained herein, your
option will vest as provided in your Grant Notice, provided that vesting will cease upon the termination of your Continuous Service. 

        2.    NUMBER OF SHARES AND EXERCISE PRICE.    The number of shares of
Common Stock subject to your option and your exercise price per share referenced in your Grant Notice may be adjusted from time to time for Capitalization Adjustments, as provided in the Plan. 

        3.    EXERCISE PRIOR TO VESTING ("EARLY EXERCISE").    If permitted in
your Grant Notice (i.e., the "Exercise Schedule" indicates that "Early Exercise" of your option is permitted) and subject to the provisions of your option, you may elect at any time that is both
(i) during the period of your Continuous Service and (ii) during the term of your option, to exercise all or part of your option, including the nonvested portion of your option;
provided, however, that: 

        (a)   a partial exercise of your option shall be deemed to cover first vested shares of Common Stock and then the earliest
vesting installment of unvested shares of Common Stock; 

        (b)   any shares of Common Stock so purchased from installments that have not vested as of the date of exercise shall be
subject to the purchase option in favor of the Company as described in the Company's form of Early Exercise Stock Purchase Agreement; 

        (c)   you shall enter into the Company's form of Early Exercise Stock Purchase Agreement with a vesting schedule that will
result in the same vesting as if no early exercise had occurred; and 

        (d)   if your option is an incentive stock option, then, as provided in the Plan, to the extent that the aggregate Fair Market
Value (determined at the time of grant) of the shares of Common Stock with respect to which your option plus all other incentive stock options you hold are exercisable for the first time by you during
any calendar year (under all plans of the Company and its Affiliates) exceeds one hundred thousand dollars ($100,000), your option(s) or portions thereof that exceed such limit (according to the order
in which they were granted) shall be treated as nonstatutory stock options. 

        4.    ISO EXERCISE LIMITATION.    

        (a)   The aggregate Fair Market Value of the shares of Common Stock with respect to which you may exercise your option for the
first time during any calendar year, when added to the aggregate Fair Market Value of the shares of Common Stock subject to any other options designated as Incentive Stock Options and granted to you
under any stock option plan of the Company or an Affiliate prior to the Date of Grant with respect to which such options are exercisable for the first time during the same calendar year, shall not
exceed $100,000 (the "ISO Exercise Limitation") unless applicable law requires that your option be exercisable sooner. For purposes of this Section 4, your options designated as Incentive Stock
Options shall be taken into account in the order in which they were granted to you, and the Fair Market Value of shares of Common Stock shall be determined as of the time the option with respect to
such shares of 

1

 

Common
Stock is granted. If Section 422 of the Code is amended to provide for a different limitation from that set forth in this provision, the ISO Exercise Limitation shall be deemed amended
effective as of the date required or permitted by such amendment to the Code. 

        (b)   Notwithstanding the provisions of Section 4(a), if the ISO Exercise Limitation would prevent you from exercising
your option as to vested shares, then the ISO Exercise Limitation shall terminate as to such vested shares as such shares vest, and you may exercise your option as to such vested shares. Upon such
termination of the ISO Exercise Limitation, your option shall be deemed a Nonstatutory Stock Option to the extent of the number of vested shares of Common Stock subject to your option that exceed the
ISO Exercise Limitation. 

        (c)   The ISO Exercise Limitation shall terminate, and you may fully exercise your option, as to all vested shares of Common
Stock subject to your option, upon the earlier of the following events: 

	(i)
	the date of termination of your Continuous Service;

	(ii)
	the day immediately prior to the effective date of a Corporate Transaction; or

	(iii)
	the day that is ten (10) days prior to the Expiration Date of your option. 

        (d)   Upon such termination of the ISO Exercise Limitation, your option shall be deemed a Nonstatutory Stock Option to the
extent of the number of shares of Common Stock subject to your option that exceed the ISO Exercise Limitation. 

        5.    METHOD OF PAYMENT.    Payment of the exercise price is due in
full upon exercise of all or any part of your option. You may elect to make payment of the exercise price in cash or by check or in any other manner permitted by your Grant
Notice, which may include one or more of the following: 

        (a)   In the Company's sole discretion at the time your option is exercised and provided that at the time of exercise the
Common Stock is publicly traded and quoted regularly in The Wall Street Journal, pursuant to a program developed under Regulation T as
promulgated by the Federal Reserve Board that, prior to the issuance of Common Stock, results in either the receipt of cash (or check) by the Company or the receipt of irrevocable instructions to pay
the aggregate exercise price to the Company from the sales proceeds. 

        (b)   Provided that at the time of exercise the Common Stock is publicly traded and quoted regularly in  The Wall Street Journal, by delivery of already
owned shares of Common Stock either that you have held for the period required to avoid a charge to the
Company's reported earnings (generally six months) or that you did not acquire, directly or indirectly from the Company, that are owned free and clear of any liens, claims, encumbrances or security
interests, and that are valued at Fair Market Value on the date of exercise. "Delivery" for these purposes, in the sole discretion of the Company at the time you exercise your option, shall include
delivery to the Company of your attestation of ownership of such shares of Common Stock in a form approved by the Company. Notwithstanding the foregoing, you may not exercise your option by tender to
the Company of Common Stock to the extent such tender would violate the provisions of any law, regulation or agreement restricting the redemption of the Company's stock. 

        6.    WHOLE SHARES.    You may exercise your option only for whole
shares of Common Stock. 

        7.    SECURITIES LAW COMPLIANCE.    Notwithstanding anything to the
contrary contained herein, you may not exercise your option unless the shares of Common Stock issuable upon such exercise are then registered under the Securities Act or, if such shares of Common
Stock are not then so registered, the Company has determined that such exercise and issuance would be exempt from the registration requirements of the Securities Act. The exercise of your option must
also comply with other applicable 

2

 

laws
and regulations governing your option, and you may not exercise your option if the Company determines that such exercise would not be in material compliance with such laws and regulations. 

        8.    TERM.    The term of your option commences on the Date of Grant
and expires upon the earliest of the following: 

        (a)   three (3) months after the termination of your Continuous Service for any reason other than your Disability or
death, provided that if during any part of such three (3) month period your option is not exercisable solely because of the condition set forth in the preceding paragraph relating to
"Securities Law Compliance," your option shall not expire until the earlier of the Expiration Date or until it shall have been exercisable for an aggregate period of three (3) months after the
termination of your Continuous Service; 

        (b)   twelve (12) months after the termination of your Continuous Service due to your Disability; 

        (c)   eighteen (18) months after your death if you die either during your Continuous Service or within three
(3) months after your Continuous Service terminates; 

        (d)   the Expiration Date indicated in your Grant Notice; or 

        (e)   the tenth (10th) anniversary of the Date of Grant. 

        If
your option is an incentive stock option, note that, to obtain the federal income tax advantages associated with an "incentive stock option," the Code requires that at all times
beginning on the date of grant of your option and ending on the day three (3) months before the date of your option's exercise, you must be an employee of the Company or an Affiliate, except in
the event of your death or Disability. The Company has provided for extended exercisability of your option under certain circumstances for your benefit but cannot guarantee that your option will
necessarily be treated as an "incentive stock option" if you continue to provide services to the Company or an Affiliate as a Consultant or Director after your employment terminates or if you
otherwise exercise your option more than three (3) months after the date your employment terminates. 

        9.    EXERCISE.    

        (a)   You may exercise the vested portion of your option (and the unvested portion of your option if your Grant Notice so
permits) during its term by delivering a Notice of Exercise (in a form designated by the Company) together with the exercise price to the Secretary of the Company, or to such other person as the
Company may designate, during regular business hours, together with such additional documents as the Company may then require. 

        (b)   By exercising your option you agree that, as a condition to any exercise of your option, the Company may require you to
enter into an arrangement providing for the payment by you to the Company of any tax withholding obligation of the Company arising by reason of (1) the exercise of your option, (2) the
lapse of any substantial risk of forfeiture to which the shares of Common Stock are subject at the time of exercise, or (3) the disposition of shares of Common Stock acquired upon such
exercise. 

        (c)   If your option is an incentive stock option, by exercising your option you agree that you will notify the Company in
writing within fifteen (15) days after the date of any disposition of any of the shares of the Common Stock issued upon exercise of your option that occurs within two (2) years after the
date of your option grant or within one (1) year after such shares of Common Stock are transferred upon exercise of your option. 

        (d)   By exercising your option you agree that the Company (or a representative of the underwriter(s)) may, in connection with
the first underwritten registration of the offering of any securities of the Company under the Securities Act, require that you not sell, dispose of, transfer, 

3

 

make
any short sale of, grant any option for the purchase of, or enter into any hedging or similar transaction with the same economic effect as a sale, any shares of Common Stock or other securities
of the Company held by you, for a period of time specified by the underwriter(s) (not to exceed one hundred eighty (180) days) following the effective date of the registration statement of the
Company filed under the Securities Act. You further agree to execute and deliver such other agreements as may be reasonably requested by the Company and/or the underwriter(s) that are consistent with
the foregoing or that are necessary to give further effect thereto. In order to enforce the foregoing covenant, the Company may impose stop-transfer instructions with respect to your
shares of Common Stock until the end of such period. 

        10.    TRANSFERABILITY.    Your option is not transferable, except by
will or by the laws of descent and distribution, and is exercisable during your life only by you. Notwithstanding the foregoing, by delivering written notice to the Company, in a form satisfactory to
the Company, you may designate a third party who, in the event of your death, shall thereafter be entitled to exercise your option. 

        11.    RIGHT OF FIRST REFUSAL.    Shares of Common Stock that you
acquire upon exercise of your option are subject to any right of first refusal that may be described in the Company's bylaws in effect at such time the Company elects to exercise its right. The
Company's right of first refusal shall expire on the Listing Date. 

        12.    RIGHT OF REPURCHASE.    To the extent provided in the Company's
bylaws as amended from time to time, the Company shall have the right to repurchase all or any part of the shares of Common Stock you acquire pursuant to the exercise of your option. In addition, if
the "Exercise Schedule" of your Grant Notice indicates "Early Exercise," then such shares will also be subject to a right of repurchase by the Company pursuant to the terms and conditions of your
Early Exercise Stock Purchase Agreement. 

        13.    OPTION NOT A SERVICE CONTRACT.    Your option is not an
employment or service contract, and nothing in your option shall be deemed to create in any way whatsoever any obligation on your part to continue in the employ of the Company or an Affiliate, or of
the Company or an Affiliate to continue your employment. In addition, nothing in your option shall obligate the Company or an Affiliate, their respective shareholders, Boards of Directors, Officers or
Employees to continue any relationship that you might have as a Director or Consultant for the Company or an Affiliate. 

        14.    WITHHOLDING OBLIGATIONS.    

        (a)   At the time you exercise your option, in whole or in part, or at any time thereafter as requested by the Company, you
hereby authorize withholding from payroll and any other amounts payable to you, and otherwise agree to make adequate provision for (including by means of a "cashless exercise" pursuant to a program
developed under Regulation T as promulgated by the Federal Reserve Board to the extent permitted by the Company), any sums required to satisfy the federal, state, local and foreign tax
withholding obligations of the Company or an Affiliate, if any, which arise in connection with your option. 

        (b)   Upon your request and subject to approval by the Company, in its sole discretion, and compliance with any applicable
conditions or restrictions of law, the Company may withhold from fully vested shares of Common Stock otherwise issuable to you upon the exercise of your option a number of whole shares of Common Stock
having a Fair Market Value, determined by the Company as of the date of exercise, not in excess of the minimum amount of tax required to be withheld by law. If the date of determination of any tax
withholding obligation is deferred to a date later than the date of exercise of your option, share withholding pursuant to the preceding sentence shall not be permitted unless you make a proper and
timely election under Section 83(b) of the Code, covering the aggregate number of shares of Common Stock acquired upon such exercise with respect to which such determination is otherwise
deferred, to accelerate the 

4

 

determination
of such tax withholding obligation to the date of exercise of your option. Notwithstanding the filing of such election, shares of Common Stock shall be withheld solely from fully vested
shares of Common Stock determined as of the date of exercise of your option that are otherwise issuable to you upon such exercise. Any adverse consequences to you arising in connection with such share
withholding procedure shall be your sole responsibility. 

        (c)   You may not exercise your option unless the tax withholding obligations of the Company and/or any Affiliate are
satisfied. Accordingly, you may not be able to exercise your option when desired even though your option is vested, and the Company shall have no obligation to issue a certificate for such shares of
Common Stock or release such shares of Common Stock from any escrow provided for herein. 

        15.    NOTICES.    Any notices provided for in your option or the Plan
shall be given in writing and shall be deemed effectively given upon receipt or, in the case of notices delivered by mail by the Company to you, five (5) days after deposit in the United States
mail, postage prepaid, addressed to you at the last address you provided to the Company. 

        16.    GOVERNING PLAN DOCUMENT.    Your option is subject to all the
provisions of the Plan, the provisions of which are hereby made a part of your option, and is further subject to all interpretations, amendments, rules and regulations which may from time to time be
promulgated and adopted pursuant to the Plan. In the event of any conflict between the provisions of your option and those of the Plan, the provisions of the Plan shall control. 

5

 
 

DEXCOM, INC.
  STOCK OPTION GRANT NOTICE
  1999 STOCK OPTION PLAN    
    

        DexCom, Inc. (the "Company"), pursuant to its 1999 Stock Option Plan (the "Plan"), hereby grants to Optionholder an option to purchase the number of shares
of the Company's Common Stock set forth below. This option is subject to all of the terms and conditions as set forth herein and in the Stock Option Agreement, the Plan and the Notice of Exercise, all
of which are attached hereto and incorporated herein in their entirety. 

	Optionholder:	 	 
	 	 	

	Date of Grant:	 	 
	 	 	

	Vesting Commencement Date:	 	 
	 	 	

	Number of Shares Subject to Option:	 	 
	 	 	

	Exercise Price (Per Share):	 	 
	 	 	

	Total Exercise Price:	 	 
	 	 	

	Expiration Date:	 	 
	 	 	

	

 	
 	

 	
 	

 	
 	

 	
 	

 
	Type of Grant:	 	o	 	Incentive Stock Option	 	o	 	Nonstatutory Stock Option
	
Exercise Schedule:	
 	

o	
 	

Same as Vesting Schedule	
 	

o	
 	

Early Exercise Permitted
	
Vesting Schedule:	
 	

1/4th of the shares vest one year after the Vesting Commencement Date

1/48th of the shares vest monthly thereafter over the next three years
	
Payment:	
 	

By one or a combination of the following items (described in the Stock Option Agreement):
	

 	
 	

 	
 	

By cash or check
	 	 	 	 	Pursuant to a Regulation T Program if the Shares are publicly traded
	 	 	 	 	By delivery of already-owned shares if the Shares are publicly traded

Additional Terms/Acknowledgements: The undersigned Optionholder acknowledges receipt of, and understands and agrees to, this Grant Notice, the Stock
Option Agreement and the Plan. Optionholder further acknowledges that as of the Date of Grant, this Grant Notice, the Stock Option Agreement and the Plan set forth the entire understanding between
Optionholder and the Company regarding the acquisition of stock in the Company and supersede all prior oral and written agreements on that subject with the exception of (i) options previously
granted and delivered to Optionholder under the Plan, and (ii) the following agreements only:

	 	 	OTHER AGREEMENTS:	 	 
	 	 	 	 	

	 	 	 	 	 
	 	 	 	 	

	 	 	 	 	 

	DEXCOM, INC.
 
	 	OPTIONHOLDER:

	By:	 	 	 	 	 	 
	 	 	
 Signature	 	
 Signature
	Title:	 	 	 	Date:	 	 
	 	 	
	 	 	 	

	Date:	 	 	 	 	 	 
	 	 	
	 	 	 	 

ATTACHMENTS:    Stock Option Agreement, 1999 Stock Option Plan and Notice of Exercise 

 
 

ATTACHMENT II    
    
    1999 STOCK OPTION PLAN    
    

 
 

ATTACHMENT III    
    
    NOTICE OF EXERCISE    
    

 
 

NOTICE OF EXERCISE    
    

	Dexcom, Inc.

6725 Mesa Ridge Road, Suite 100

San Diego, CA 92121	 	

Date of Exercise:	 
	 	 	 	

Ladies
and Gentlemen: 

        This
constitutes notice under my stock option that I elect to purchase the number of shares for the price set forth below. 

	Type of option (check one):	 	Incentive o	 	Nonstatutory o
	

Stock option dated:	
 	

                     	
 	

 
	

Number of shares as to which option is exercised:	
 	

                     	
 	

 
	

Certificates to be issued in name of:	
 	

                     	
 	

 
	

Total exercise price:	
 	

$                 	
 	

 
	

Cash payment delivered herewith:	
 	

$                 	
 	

 

        By
this exercise, I agree (i) to provide such additional documents as you may require pursuant to the terms of the 1999 Stock Option Plan, (ii) to provide for the payment
by me to you (in the manner designated by you) of your withholding obligation, if any, relating to the exercise of this option, and (iii) if this exercise relates to an incentive stock option,
to notify you in writing within fifteen (15) days after the date of any disposition of any of the shares of Common Stock issued upon exercise of this option that occurs within two
(2) years after the date of grant of this option or within one (1) year after such shares of Common Stock are issued upon exercise of this option. 

        I
hereby make the following certifications and representations with respect to the number of shares of Common Stock of the Company listed above (the "Shares"), which are being acquired
by me for my own account upon exercise of the Option as set forth above: 

        I
acknowledge that the Shares have not been registered under the Securities Act of 1933, as amended (the "Securities Act"), and are deemed to constitute "restricted securities" under
Rule 701 and "control securities" under Rule 144 promulgated under the Securities Act. I warrant and represent to the Company that I have no present intention of distributing or selling
said Shares, except as permitted under the Securities Act and any applicable state securities laws. 

        I
further acknowledge that I will not be able to resell the Shares for at least ninety days (90) after the stock of the Company becomes publicly traded
(i.e., subject tot the reporting requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934) under Rule 701 and that more
restrictive conditions apply to affiliates of the Company under Rule 144. 

        I
further acknowledge that all certificates representing any of the Shares subject to the provisions of the Option shall have endorsed thereon appropriate legends reflecting the
foregoing limitations, as well as any legends reflecting restrictions pursuant to the Company's Articles of Incorporation, Bylaws and/or applicable securities laws. 

        I
further agree that, if required by the Company (or a representative of the underwriters) in connection with the first underwritten registration of the offering of any securities of the
Company under the Securities Act, I will not sell, dispose of, transfer, make any short sale of, grant any option for the purchase of, or enter into any hedging or similar transaction with the same
economic effect as a sale, any Shares or other securities of the Company held by me, for a period of time specified by the underwriter(s) (not to exceed one hundred eighty (180) days) following
the effective date of the registration statement of the Company filed under the Securities Act. I further agree to execute and deliver such other agreements as may be reasonably requested by the
Company and/or the 

 

underwriter(s)
that are consistent with the foregoing or that are necessary to give further effect thereto. In order to enforce the foregoing covenant, the Company may impose stop-transfer
instructions with respect to my Shares until the end of such period. 

	 	 	Very truly yours,
	 	 	 
	 	 	 
	 	 	 
	 	 	 

2

  

 
 

DEXCOM, INC.    
    
    EARLY EXERCISE STOCK PURCHASE AGREEMENT
  UNDER THE 1999 STOCK OPTION PLAN    
    

        THIS AGREEMENT is made by and between DexCom, Inc., a
Delaware corporation (the "Company"), and                        ("Purchaser"). 

WITNESSETH:  

        WHEREAS, Purchaser holds a stock option
dated                        to purchase            shares of common
stock
("Common Stock") of the Company (the "Option") pursuant to the Company's 1999 Stock Option Plan (the "Plan"); and 

        WHEREAS, the Option consists of a Stock Option Grant Notice and a Stock Option Agreement; and 

        WHEREAS, Purchaser desires to exercise the Option on the terms and conditions contained herein; and 

        WHEREAS, Purchaser wishes to take advantage of the early exercise provision of the Purchaser's Option and therefore to enter into this
Agreement; 

        NOW, THEREFORE, IT IS AGREED between the parties as follows: 

        1.    INCORPORATION OF PLAN AND OPTION BY REFERENCE.    This Agreement
is subject to all of the terms and conditions as set forth in the Plan and the Option. If there is a conflict between the terms of this Agreement and/or the Option and the terms of the Plan, the terms
of the Plan shall control. If there is a conflict between the terms of this Agreement and the terms of the Option, the terms of the Option
shall control. Defined terms not explicitly defined in this Agreement but defined in the Plan shall have the same definitions as in the Plan. Defined terms not explicitly defined in this Agreement or
the Plan but defined in the Option shall have the same definitions as in the Option. 

        2.    PURCHASE AND SALE OF COMMON STOCK.    

        (a)    Agreement to purchase and sell Common Stock.    Purchaser
hereby agrees to purchase from the Company, and the Company hereby agrees to sell to Purchaser, shares of the Common Stock of the Company in accordance with the Notice of Exercise duly executed by
Purchaser and attached hereto as Exhibit A. 

        (b)    Closing.    The closing hereunder, including payment for and
delivery of the Common Stock, shall occur at the offices of the Company immediately following the execution of this Agreement, or at such other time and place as the parties may mutually agree;  provided, however,
 that if stockholder approval of the Plan is required before the Option may be exercised, then the Option may not be exercised, and
the closing shall be delayed, until such stockholder approval is obtained. If such stockholder approval is not obtained within the time limit specified in the Plan, then this Agreement shall be null
and void. 

        3.    UNVESTED SHARE REPURCHASE OPTION    

        (a)    Repurchase Option.    In the event Purchaser's Continuous
Service terminates, then the Company shall have an irrevocable option (the "Repurchase Option") for a period of ninety (90) days after said termination (or in the case of shares issued upon
exercise of the Option after such date of termination, within ninety (90) days after the date of the exercise), or such longer period as may be agreed to by the Company and the Purchaser, to
repurchase from Purchaser or Purchaser's personal representative, as the case may be, those shares that Purchaser received pursuant to the exercise of the Option that have not as yet vested as of such
termination date in 

1

 

accordance
with the Vesting Schedule indicated on Purchaser's Stock Option Grant Notice (the "Unvested Shares"). 

        (b)    Shares Repurchasable at Purchaser's Original Exercise
Price.    The Company may repurchase all or any of the Unvested Shares at a price ("Option Price") equal to the Purchaser's Exercise Price for such shares as
indicated on Purchaser's Stock Option Grant Notice. 

        4.    EXERCISE OF REPURCHASE OPTION.    The Repurchase Option shall be
exercised by written notice signed by an Officer of the Company and delivered or mailed as provided herein. Such notice shall identify the number of shares of Common Stock to be purchased and shall
notify Purchaser of the time, place and date for settlement of such purchase, which shall be scheduled by the Company within the term of the Repurchase Option set forth above. The Company shall be
entitled to pay for any shares of Common Stock purchased pursuant to its Repurchase Option at the Company's option in cash or by offset against any indebtedness owing to the Company by Purchaser
(including without limitation any Note given in payment for the Common Stock), or by a combination of both. Upon delivery of such notice and payment of the purchase price in any of the ways described
above, the Company shall become the legal and beneficial owner of the Common Stock being repurchased and all rights and interest therein or related thereto, and the Company shall have the right to
transfer to its own name the Common Stock being repurchased by the Company, without further action by Purchaser. 

        5.    CAPITALIZATION ADJUSTMENTS TO COMMON STOCK.    In the event of a
"Capitalization Adjustment" affecting the Company's outstanding Common Stock as a class as designated in the Plan, then any and all new, substituted or additional securities or other property to which
Purchaser is entitled by reason of Purchaser's ownership of Common Stock shall be immediately subject to the Repurchase Option and be included in the word "Common Stock" for all purposes of the
Repurchase Option with the same force and effect as the shares of the Common Stock presently subject to the Repurchase Option, but only to the extent the Common Stock is, at the time, covered by such
Repurchase Option. While the total Option Price shall remain the same after each such event, the Option Price per share of Common Stock upon exercise of the Repurchase Option shall be appropriately
adjusted. 

        6.    CORPORATE TRANSACTIONS.    In the event of a Corporate
Transaction described in subsection 10(c) of the Plan, then the Repurchase Option may be assigned by the Company to the successor of the Company (or such successor's parent company), if any, in
connection with such Corporate Transaction. To the extent the Repurchase Option remains in effect following such Corporate Transaction, it shall apply to the new capital stock or other property
received in exchange for the Common Stock in consummation of the Corporate Transaction, but only to the extent the Common Stock was at the time covered by such right. Appropriate adjustments shall be
made to the price per share payable upon exercise of the Repurchase Option to reflect the Corporate Transaction upon the Company's capital structure; provided, however, that the aggregate Option Price
shall remain the same. 

        7.    ESCROW OF UNVESTED COMMON STOCK.    As security for Purchaser's
faithful performance of the terms of this Agreement and to insure the availability for delivery of Purchaser's Common Stock upon exercise of the Repurchase Option herein provided for, Purchaser
agrees, at the closing hereunder, to deliver to and deposit with the Secretary of the Company or the Secretary's designee ("Escrow Agent"), as Escrow Agent in this transaction, three (3) stock
assignments duly endorsed (with date and number of shares blank) in the form attached hereto as Exhibit B, together with a certificate or
certificates evidencing all of the Common Stock subject to the Repurchase Option; said documents are to be held by the Escrow Agent and delivered by said Escrow Agent pursuant to the Joint Escrow
Instructions of the Company and Purchaser set forth in Exhibit C, attached hereto and incorporated by this reference, which instructions shall
also be delivered to the Escrow Agent at the closing hereunder. 

        8.    RIGHTS OF PURCHASER.    Subject to the provisions of the Option,
Purchaser shall exercise all rights and privileges of a stockholder of the Company with respect to the shares deposited in escrow. 

2

 

Purchaser
shall be deemed to be the holder of the shares for purposes of receiving any dividends that may be paid with respect to such shares and for purposes of exercising any voting rights relating
to such shares, even if some or all of such shares have not yet vested and been released from the Company's Repurchase Option. 

        9.    LIMITATIONS ON TRANSFER.    In addition to any other limitation
on transfer created by applicable securities laws, Purchaser shall not sell, assign, hypothecate, donate, encumber or otherwise dispose of any interest in the Common Stock while the Common Stock is
subject to the Repurchase Option. After any Common Stock has been released from the Repurchase Option, Purchaser shall not sell, assign, hypothecate, donate, encumber or otherwise dispose of any
interest in the Common Stock except in compliance with the provisions herein and applicable securities laws. Furthermore, the Common Stock shall be subject to any right of first refusal in favor of
the Company or its assignees that may be contained in the Company's Bylaws. 

        10.    RESTRICTIVE LEGENDS.    All certificates representing the
Common Stock shall have endorsed thereon legends in substantially the following forms (in addition to any other legend which may be required by other agreements between the parties hereto): 

        (a)   "THE SHARES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO AN OPTION SET FORTH IN AN AGREEMENT BETWEEN THE COMPANY AND
THE REGISTERED HOLDER, OR SUCH HOLDER'S PREDECESSOR IN INTEREST, A COPY OF WHICH IS ON FILE AT THE PRINCIPAL OFFICE OF THIS COMPANY. ANY TRANSFER OR ATTEMPTED TRANSFER OF ANY SHARES SUBJECT TO SUCH
OPTION IS VOID WITHOUT THE PRIOR EXPRESS WRITTEN CONSENT OF THE COMPANY." 

        (b)   "THE SHARES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933 AS AMENDED. THEY
MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED OR HYPOTHECATED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT AS TO THE SECURITIES UNDER SAID ACT OR AN OPINION OF COUNSEL SATISFACTORY TO THE
COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED." 

        (c)   "THE SHARES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO A RIGHT OF FIRST REFUSAL OPTION IN FAVOR OF THE COMPANY AS
PROVIDED IN THE BYLAWS OF THE COMPANY." 

        (d)   Any legend required by appropriate blue sky officials. 

        11.    INVESTMENT REPRESENTATIONS.    In connection with the purchase
of the Common Stock, Purchaser represents to the Company the following: 

        (a)   Purchaser is aware of the Company's business affairs and financial condition and has acquired sufficient information
about the Company to reach an informed and knowledgeable decision to acquire the Common Stock. Purchaser is acquiring the Common Stock for investment for Purchaser's own account only and not with a
view to, or for resale in connection with, any "distribution" thereof within the meaning of the Securities Act. 

        (b)   Purchaser understands that the Common Stock has not been registered under the Securities Act by reason of a specific
exemption therefrom, which exemption depends upon, among other things, the bona fide nature of Purchaser's investment intent as expressed herein. 

        (c)   Purchaser further acknowledges and understands that the Common Stock must be held indefinitely unless the Common Stock is
subsequently registered under the Securities Act or an exemption from such registration is available. Purchaser further acknowledges and understands that the Company is under no obligation to register
the Common Stock. Purchaser understands that the certificate evidencing the Common Stock will be imprinted with a legend that prohibits the transfer 

3

 

of
the Common Stock unless the Common Stock is registered or such registration is not required in the opinion of counsel for the Company. 

        (d)   Purchaser is familiar with the provisions of Rules 144 and 701, under the Securities Act, as in effect from time
to time, which, in substance, permit limited public resale of "restricted securities" acquired, directly or indirectly, from the issuer thereof (or from an affiliate of such issuer), in a
non-public offering subject to the satisfaction of certain conditions. Rule 701 provides that if the issuer qualifies under Rule 701 at the time of issuance of the
securities, such issuance will be exempt from registration under the Securities Act. In the event the Company becomes subject to the reporting requirements of Section 13 or 15(d) of the
Securities Exchange Act of 1934, the securities exempt under Rule 701 may be sold by Purchaser ninety (90) days thereafter, subject to the satisfaction of certain of the conditions
specified by Rule 144 and the market stand-off provision described in Purchaser's Stock Option Agreement. 

        (e)   In the event that the sale of the Common Stock does not qualify under Rule 701 at the time of purchase, then the
Common Stock may be resold by Purchaser in certain limited circumstances subject
to the provisions of Rule 144, which requires, among other things: (i) the availability of certain public information about the Company and (ii) the resale occurring following the
required holding period under Rule 144 after the Purchaser has purchased, and made full payment of (within the meaning of Rule 144), the securities to be sold. 

        (f)    Purchaser further understands that at the time Purchaser wishes to sell the Common Stock there may be no public market
upon which to make such a sale, and that, even if such a public market then exists, the Company may not be satisfying the current public current information requirements of Rule 144 or 701, and
that, in such event, Purchaser would be precluded from selling the Common Stock under Rule 144 or 701 even if the minimum holding period requirement had been satisfied. 

        12.    MARKET STAND-OFF AGREEMENT.    By exercising the
Option Purchaser agrees that the Company (or a representative of the underwriters) may, in connection with any underwritten registration of the offering of any securities of the Company under the
Securities Act, require that the Purchaser not sell, dispose of, transfer, make any short sale of, grant any option for the purchase of, or enter into any hedging or similar transaction with the same
economic effect as a sale, any shares of Common Stock or other securities of the Company held by Purchaser, for a period of time specified by the underwriter(s) (not to exceed one hundred eighty
(180) days) following the effective date of the registration statement of the Company filed under the Securities Act. Purchaser further agrees to execute and deliver such other agreements as
may be reasonably requested by the Company and/or the underwriter(s) that are consistent with the foregoing or that are necessary to give further effect thereto. In order to enforce the foregoing
covenant, the Company may impose stop-transfer instructions with respect to Purchaser's Common Stock until the end of such period. The underwriters of the Company's stock are intended
third party beneficiaries of this Section 12 and shall have the right, power and authority to enforce the provisions hereof as though they were a party hereto. 

        13.    SECTION 83(b) ELECTION.    Purchaser understands that Section 83(a) of the
Code, taxes as ordinary income the difference between the amount paid for the Common Stock and the
fair market value of the Common Stock as of the date any restrictions on the Common Stock lapse. In this context, "restriction" includes the right of the Company to buy back the Common Stock pursuant
to the Repurchase Option set forth above. Purchaser understands that Purchaser may elect to be taxed at the time the Common Stock is purchased, rather than when and as the Repurchase Option expires,
by filing an election under Section 83(b) attached hereto as Exhibit D (an "83(b) Election") of the Code with the Internal Revenue Service
within thirty (30) days from the date of purchase. Even if the fair market value of the Common Stock at the time of the execution of this Agreement equals the amount paid for the Common Stock,
the 83(b) Election must be made to avoid income under Section 83(a) in 

4

 

the
future. Purchaser understands that failure to file such an 83(b) Election in a timely manner may result in adverse tax consequences for Purchaser. Purchaser further understands that Purchaser must
file an additional copy of such 83(b) Election with his or her federal income tax return for the calendar year in which the date of this Agreement falls. Purchaser acknowledges that the foregoing is
only a summary of the effect of United States federal income taxation with respect to purchase of the Common Stock hereunder, and does not purport to be complete. Purchaser further acknowledges that
the Company has directed Purchaser to seek independent advice regarding the applicable provisions of the Code, the income tax laws of any municipality, state or foreign country in which Purchaser may
reside, and the tax consequences of Purchaser's death. Purchaser assumes all responsibility for filing an 83(b) Election and paying all taxes resulting from such election or the lapse of the
restrictions on the Common Stock. 

        14.    REFUSAL TO TRANSFER.    The Company shall not be required
(a) to transfer on its books any shares of Common Stock of the Company which shall have been transferred in violation of any of the provisions set forth in this Agreement or (b) to treat
as owner of such shares or to accord the right to vote as such owner or to pay dividends to any transferee to whom such shares shall have been so transferred. 

        15.    NO EMPLOYMENT RIGHTS.    This Agreement is not an employment
contract and nothing in this Agreement shall affect in any manner whatsoever the right or power of the Company (or a parent or subsidiary of the Company) to terminate Purchaser's employment for any
reason at any time, with or without cause and with or without notice. 

        16.    MISCELLANEOUS.    

        (a)    Notices.    Any notice required or permitted hereunder shall be
given in writing and shall be deemed effectively given upon personal delivery or sent by telegram or fax or upon deposit in the United States Post Office, by registered or certified mail with postage
and fees prepaid, addressed to the other party hereto at such party's address hereinafter shown below its signature or at such other address as such party may designate by ten (10) days'
advance written notice to the other party hereto. 

        (b)    Successors and Assigns.    This Agreement shall inure to the
benefit of the successors and assigns of the Company and, subject to the restrictions on transfer herein set forth, be binding upon Purchaser, Purchaser's successors, and assigns. The Company may
assign the Repurchase Option hereunder at any time or from time to time, in whole or in part. 

        (c)    Attorneys' Fees; Specific Performance.    Purchaser shall
reimburse the Company for all costs incurred by the Company in enforcing the performance of, or protecting its rights under, any part of this Agreement, including reasonable costs of investigation and
attorneys' fees. It is the intention of the parties that the Company, upon exercise of the Repurchase Option and payment of the Option Price, pursuant to the terms of this Agreement, shall be entitled
to receive the Common Stock, in specie, in order to have such Common Stock available for future issuance without dilution of the holdings of other stockholders. Furthermore, it is expressly agreed
between the parties that money damages are inadequate to compensate the Company for the Common Stock and that the Company shall, upon proper exercise of the Repurchase Option, be entitled to specific
enforcement of its rights to purchase and receive said Common Stock. 

        (d)    Governing Law; Venue.    This Agreement shall be governed by
and construed in accordance with the laws of the State of California. The parties agree that any action brought by either party to interpret or enforce any provision of this Agreement shall be brought
in, and each party agrees to, and does hereby, submit to the jurisdiction and venue of, the appropriate state or federal court for the district encompassing the Company's principal place of business. 

5

 

        (e)    Further Execution.    The parties agree to take all such
further action(s) as may reasonably be necessary to carry out and consummate this Agreement as soon as practicable, and to take whatever steps may be necessary to obtain any governmental approval in
connection with or otherwise qualify the issuance of the securities that are the subject of this Agreement. 

        (f)    Independent Counsel.    Purchaser acknowledges that this
Agreement has been prepared on behalf of the Company by Cooley Godward llp, counsel to the Company and that Cooley Godward llp does not represent, and is not acting on behalf of, Purchaser. Purchaser
has been provided with an opportunity to consult with Purchaser's own counsel with respect to this Agreement. 

        (g)    Entire Agreement; Amendment.    This Agreement constitutes the
entire agreement between the parties with respect to the subject matter hereof and supersedes and merges all prior agreements or understandings, whether written or oral. This Agreement may not be
amended, modified or revoked, in whole or in part, except by an agreement in writing signed by each of the parties hereto. 

        (h)    Severability.    If one or more provisions of this Agreement
are held to be unenforceable under applicable law, the parties agree to renegotiate such provision in good faith. In the event that the parties cannot reach a mutually agreeable and enforceable
replacement for such provision, then (i) such provision shall be excluded from this Agreement, (ii) the balance of the Agreement shall be interpreted as if such provision were so
excluded and (iii) the balance of the Agreement shall be enforceable in accordance with its terms. 

        (i)    Counterparts.    This Agreement may be executed in two or more
counterparts, each of which shall be deemed an original and all of which together shall constitute one instrument. 

        IN WITNESS WHEREOF, the parties hereto have executed this Agreement as
of                        ,
                        .

	 	 	DEXCOM, INC.
	 	 	 	 
	 	 	 	 
	 	 	By	 
	 	 	 	

	 	 	Title	 
	 	 	 	

	 	 	Address:	6725 Mesa Ridge Road, #100

San Diego, CA 92121
	 	 	 	 
	 	 	 	 
	 	 	[NAME]	 
	 	 	 	 
	 	 	 	

	 	 	Address:	 
	 	 	 	

	 	 	 	 
	 	 	 	

Attachments:  

	Exhibit A	 	Notice of Exercise
	Exhibit B	 	Assignment Separate from Certificate
	Exhibit C	 	Joint Escrow Instructions
	Exhibit D	 	83(b) Election Form

6

 
 

EXHIBIT A    
    
    NOTICE OF EXERCISE    
    

 
NOTICE OF EXERCISE  

DexCom, Inc.

6725 Mesa Ridge Road, Suite 100

San Diego, CA 92121 

Date
of Exercise:                         , 20            

Ladies
and Gentlemen: 

        This
constitutes notice under my stock option that I elect to purchase the number of shares for the price set forth below. 

	 	 	Type of option (check one):	 	Incentive o	 	Nonstatutory o
	

 	
 	

Stock option dated:	
 	

                     	
 	

 
	

 	
 	

Number of shares as to which option is exercised:	
 	

        

                     	
 	

 
	

 	
 	

Certificates to be issued in name of:	
 	

                     	
 	

 
	

 	
 	

Total exercise price:	
 	

$                 	
 	

 
	

 	
 	

Cash payment delivered herewith:	
 	

$                 	
 	

 

        By
this exercise, I agree (i) to provide such additional documents as you may require pursuant to the terms of the 1999 Stock Option Plan, (ii) to provide for the payment
by me to you (in the manner designated by you) of your withholding obligation, if any, relating to the exercise of this option, and (iii) if this exercise relates to an incentive stock option,
to notify you in writing within fifteen (15) days after the date of any disposition of any of the shares of Common Stock issued upon exercise of this option that occurs within two
(2) years after the date of grant of this option or within one (1) year after such shares of Common Stock are issued upon exercise of this option. 

        I
hereby make the following certifications and representations with respect to the number of shares of Common Stock of the Company listed above (the "Shares"), which are being acquired
by me for my own account upon exercise of the Option as set forth above: 

        I
acknowledge that the Shares have not been registered under the Securities Act of 1933, as amended (the "Securities Act"), and are deemed to constitute "restricted securities" under
Rule 701 and "control securities" under Rule 144 promulgated under the Securities Act. I warrant and represent to the Company that I have no present intention of distributing or selling
said Shares, except as permitted under the Securities Act and any applicable state securities laws. 

        I
further acknowledge that I will not be able to resell the Shares for at least ninety days (90) after the stock of the Company becomes publicly traded
(i.e., subject to the reporting requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934) under Rule 701 and that more
restrictive conditions apply to affiliates of the Company under Rule 144. 

        I
further acknowledge that all certificates representing any of the Shares subject to the provisions of the Option shall have endorsed thereon appropriate legends reflecting the
foregoing limitations, as well as any legends reflecting restrictions pursuant to the Company's Articles of Incorporation, Bylaws and/or applicable securities laws. 

        (j)    I further agree that, if required by the Company (or a representative of the underwriters) in connection with the first
underwritten registration of the offering of any securities of the Company under the Securities Act, I will not sell, dispose of, transfer, make any short sale of, grant any option for the purchase
of, or enter into any hedging or similar transaction with the same economic effect as a sale, any Shares or other securities of the Company held by me, for a 

1

 

period
of time specified by the underwriter(s) (not to exceed one hundred eighty (180) days) following the effective date of the registration statement of the Company filed under the Securities
Act. I further agree to execute and deliver such other agreements as may be reasonably requested by the Company and/or the underwriter(s) that are consistent with the foregoing or that are necessary
to give further effect thereto. In order to enforce the foregoing covenant, the Company may impose stop-transfer instructions with respect to my Shares until the end of such period. 

	 	 	Very truly yours,
	 	 	 
	 	 	 
	 	 	[NAME]
	

 	
 	

	 	 	 
	 	 	 

2

 
 

EXHIBIT B    
    
    STOCK ASSIGNMENT SEPARATE FROM CERTIFICATE    
    

STOCK ASSIGNMENT SEPARATE FROM CERTIFICATE  

        FOR VALUE RECEIVED,                        hereby sells, assigns and transfers unto
DexCom, Inc., a Delaware corporation (the "Company"), pursuant to the Repurchase Option under that certain Early Exercise Stock Purchase Agreement,
dated                        ,            by and
between the undersigned and the Company (the "Agreement"),                        
(            ) shares of Common Stock of the Company standing in the undersigned's name on the books of the Company
represented by Certificate No(s).            and does hereby irrevocably constitute and appoint the Cooley Godward LLP attorney to transfer said Common Stock on the books of the Company with
full
power of substitution in the premises. This Assignment may be used only in accordance with and subject to the terms and conditions of the Agreement, in connection with the repurchase of shares of
Common Stock issued to the undersigned pursuant to the Agreement, and only to the extent that such shares remain subject to the Company's Repurchase Option under the Agreement. 

	 	 	 	 	 
	Dated:	 	 	 	 
	 	 	
	 	 
	 	 	 	 	 
	 	 	 	 	[NAME]
	 	 	 	 	 
	 	 	 	 	 
	 	 	 	 	
 (Signature)

(INSTRUCTION:    Please do not fill in any blanks other than the "Signature" line and the "Print Name"
line.)

 
 

EXHIBIT C    
    
    JOINT ESCROW INSTRUCTIONS    
    

JOINT ESCROW INSTRUCTIONS  

DexCom, Inc.

6725 Mesa Ridge Road, Suite 100

San Diego, CA 92121 

Dear
Sir or Madam: 

        As
Escrow Agent for both DexCom, Inc., a Delaware corporation ("Company"), and the undersigned purchaser of Common Stock of the
Company ("Purchaser"), you are hereby authorized and directed to hold the documents delivered to you pursuant to the terms of that certain Early Exercise Stock Purchase Agreement ("Agreement"), dated
                        ,            to which a copy of these Joint
Escrow Instructions is attached as Exhibit C, in accordance with the following instructions: 

        1.     In the event the Company or an assignee shall elect to exercise the Repurchase Option set forth in the Agreement, the
Company or its assignee will give to Purchaser and you a written notice specifying the number of shares of Common Stock to be purchased, the purchase price, and the time for a closing hereunder at the
principal office of the Company. Purchaser and the Company hereby irrevocably
authorize and direct you to close the transaction contemplated by such notice in accordance with the terms of said notice. 

        2.     At the closing you are directed (a) to date any stock assignments necessary for the transfer in question,
(b) to fill in the number of shares being transferred, and (c) to deliver same, together with the certificate evidencing the shares of Common Stock to be transferred, to the Company
against the simultaneous delivery to you of the purchase price (which may include suitable acknowledgment of cancellation of indebtedness) of the number of shares of Common Stock being purchased
pursuant to the exercise of the Repurchase Option. 

        3.     Purchaser irrevocably authorizes the Company to deposit with you any certificates evidencing shares of Common Stock to be
held by you hereunder and any additions and substitutions to said shares as specified in the Agreement. Purchaser does hereby irrevocably constitute and appoint you as the Purchaser's
attorney-in-fact and agent for the term of this escrow to execute with respect to such securities and other property all documents of assignment and/or transfer and all stock
certificates necessary or appropriate to make all securities negotiable and complete any transaction herein contemplated. 

        4.     This escrow shall terminate upon expiration or exercise in full of the Repurchase Option, whichever occurs first. 

        5.     If at the time of termination of this escrow you should have in your possession any documents, securities, or other
property belonging to Purchaser, you shall deliver all of same to Purchaser and shall be discharged of all further obligations hereunder; provided,
however, that if at the time of termination of this escrow you are advised by the Company that the property subject to this escrow is the subject of a pledge or other security
agreement, you shall deliver all such property to the pledgeholder or other person designated by the Company. 

        6.     Except as otherwise provided in these Joint Escrow Instructions, your duties hereunder may be altered, amended, modified
or revoked only by a writing signed by all of the parties hereto. 

        7.     You shall be obligated only for the performance of such duties as are specifically set forth herein and may rely and shall
be protected in relying or refraining from acting on any instrument reasonably believed by you to be genuine and to have been signed or presented by the proper party or parties or their assignees. You
shall not be personally liable for any act you may do or omit to do hereunder as Escrow Agent or as attorney-in-fact for Purchaser while acting in good faith and any act done
or omitted by you pursuant to the advice of your own attorneys shall be conclusive evidence of such good faith. 

        8.     You are hereby expressly authorized to disregard any and all warnings given by any of the parties hereto or by any other
person or corporation, excepting only orders or process of courts of law, and are hereby expressly authorized to comply with and obey orders, judgments or decrees of any court. In case you obey or
comply with any such order, judgment or decree of any court, you shall not be liable to any of the parties hereto or to any other person, firm or corporation by reason of such compliance,
notwithstanding any such order, judgment or decree being subsequently reversed, modified, annulled, set aside, vacated or found to have been entered without jurisdiction. 

        9.     You shall not be liable in any respect on account of the identity, authority or rights of the parties executing or
delivering or purporting to execute or deliver the Agreement or any documents or papers deposited or called for hereunder. 

        10.   You shall not be liable for the outlawing of any rights under any statute of limitations with respect to these Joint
Escrow Instructions or any documents deposited with you. 

        11.   Your responsibilities as Escrow Agent hereunder shall terminate if you shall cease to be Secretary of the Company or if
you shall resign by written notice to each party. In the event of any such termination, the Company may appoint any officer or assistant officer of the Company as successor Escrow Agent and Purchaser
hereby confirms the appointment of such successor or successors as the Purchaser's attorney-in-fact and agent to the full extent of your appointment. 

        12.   If you reasonably require other or further instruments in connection with these Joint Escrow Instructions or obligations
in respect hereto, the necessary parties hereto shall join in furnishing such instruments. 

        13.   It is understood and agreed that should any dispute arise with respect to the delivery and/or ownership or right of
possession of the securities, you are authorized and directed to retain in your possession without liability to anyone all or any part of said securities until such dispute shall have been
settled either by mutual written agreement of the parties concerned or by a final order, decree or judgment of a court of competent jurisdiction after the time for appeal has expired and no appeal has
been perfected, but you shall be under no duty whatsoever to institute or defend any such proceedings. 

        14.   Any notice required or permitted hereunder shall be given in writing and shall be deemed effectively given upon personal
delivery, including delivery by express courier or five days after deposit in the United States Post Office, by registered or certified mail with postage and fees prepaid, addressed to each of the
other parties hereunto entitled at the following addresses, or at such other addresses as a party may designate by ten days' advance written notice to each of the other parties hereto: 

	 	 	COMPANY:	 	DexCom, Inc.

6725 Mesa Ridge Road, Suite 100

San Diego, CA 92121
	 	 	 	 	 
	 	 	PURCHASER:	 	 
	 	 	 	 	

	 	 	 	 	 
	 	 	 	 	

	 	 	 	 	 
	 	 	 	 	

	 	 	 	 	 
	 	 	ESCROW AGENT:	 	DexCom, Inc.

6725 Mesa Ridge Road, Suite 100

San Diego, CA 92121

        15.   By signing these Joint Escrow Instructions you become a party hereto only for the purpose of said Joint Escrow
Instructions; you do not become a party to the Agreement. 

        16.   You shall be entitled to employ such legal counsel and other experts (including without limitation the firm of Cooley
Godward llp) as you may deem necessary properly to advise you in 

connection
with your obligations hereunder. You may rely upon the advice of such counsel, and may pay such counsel reasonable compensation therefor. The Company shall be responsible for all fees
generated by such legal counsel in connection with your obligations hereunder. 

        17.   This instrument shall be binding upon and inure to the benefit of the parties hereto and their respective successors and
permitted assigns. It is understood and agreed that references to "you" or "your" herein refer to the original Escrow Agent and to any and all successor Escrow Agents. It is understood and agreed that
the Company may at any time or from time to time assign its rights under the Agreement and these Joint Escrow Instructions in whole or in part. 

        18.   This Agreement shall be governed by and interpreted and determined in accordance with the laws of the State of
California, as such laws are applied by California courts to contracts made and to be performed entirely in California by residents of that state. 

	 	 	 	 	 
	 	 	Very truly yours,
	 	 	 	 	 
	 	 	DEXCOM, INC.
	 	 	 	 	 
	 	 	 	 	 
	 	 	By	 	 
	 	 	 	 	

	 	 	Title	 	 
	 	 	 	 	

	 	 	 	 	 
	 	 	 	 	 
	 	 	PURCHASER:

[NAME]
	 	 	 	 	 
	 	 	 	 	 
	 	 	

	 	 	 	 	 
	 	 	 	 	 
	ESCROW AGENT:

DEXCOM, INC.

 

    
	 	 	 	 

 
 

EXHIBIT D    
    
    83(B) ELECTION    
    

Director
of Internal Revenue

Internal Revenue Service Center

5045 East Butler Avenue

Fresno, CA 93888 

	Re:
	Election
Under Section 83(b) 

Gentlemen:

        This
statement constitutes an election pursuant to Section 83(b) of the Internal Revenue Code of 1986, as amended from time to time. 

        Pursuant
to Treasury Regulations Section 1.83-2, the following information is submitted:

	 	 	1.	 	Name:	 	 	 	("Purchaser")
	 	 	 	 	 	 	
	 	 
	 	 	 	 	 	 	 	 	 
	 	 	 	 	Address:	 	 	 	 
	 	 	 	 	 	 	
	 	 
	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	
	 	 
	 	 	 	 	 	 	 	 	 
	 	 	 	 	Social Security No.:	 	 	 	 
	 	 	 	 	 	 	
	 	 
	

 	
 	
2.	
 	
Property Description:                         shares of the Common Stock
(the "Stock") of DexCom, Inc., a Delaware corporation (the "Corporation").
	

 	
 	
3.	
 	

The date on which the property was transferred is                        .
	

 	
 	
4.	
 	

The taxable year for which the election is made is the calendar year            .
	

 	
 	
5.	
 	

Restrictions:
	

 	
 	

 	
 	

"In the event Purchaser's Continuous Service terminates, then the Company shall have an irrevocable option (the "Repurchase Option") for a period of ninety (90) days after said termination (or in the case of shares issued upon exercise of the
Option after such date of termination, within ninety (90) days after the date of the exercise), or such longer period as may be agreed to by the Company and the Purchaser, to repurchase from Purchaser or Purchaser's personal representative, as
the case may be, those shares that Purchaser received pursuant to the exercise of the Option that have not as yet vested as of such termination date in accordance with the Vesting Schedule indicated on Purchaser's Stock Option Grant
Notice."
	

 	
 	
6.	
 	

The fair market value at the time of transfer of the Stock, determined without regard to any restriction other than a restriction which by its terms will never lapse, is $    per share.
	

 	
 	
7.	
 	

The amount paid by the undersigned taxpayer for the property is $            .
	

 	
 	
8.	
 	

A copy of this statement has been furnished to DexCom, Inc. and the transferee of the property if different from the Purchaser.

	 	 	 	 
	Dated:	 	 	 
	 	
	 	 
	 	 	 	 
	Very truly yours,	 	 
	    	 	 	 
	    	 	 	 
	    	 	 	 
	
	 	 

QuickLinks

DEXCOM, INC. 1999 STOCK OPTION PLAN As approved by the Board of Directors on August 11, 1999 and amended through December 7, 2004

ATTACHMENT I STOCK OPTION AGREEMENT

DEXCOM, INC. 1999 STOCK OPTION PLAN STOCK OPTION AGREEMENT (INCENTIVE AND NONSTATUTORY STOCK OPTIONS)

DEXCOM, INC. STOCK OPTION GRANT NOTICE 1999 STOCK OPTION PLAN

ATTACHMENT II 1999 STOCK OPTION PLAN

ATTACHMENT III NOTICE OF EXERCISE

NOTICE OF EXERCISE

DEXCOM, INC. EARLY EXERCISE STOCK PURCHASE AGREEMENT UNDER THE 1999 STOCK OPTION PLAN

EXHIBIT A NOTICE OF EXERCISE

EXHIBIT B STOCK ASSIGNMENT SEPARATE FROM CERTIFICATE

EXHIBIT C JOINT ESCROW INSTRUCTIONS

EXHIBIT D 83(B) ELECTIONQuickLinks
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Exhibit 10.08  

 
 

SORRENTO VALLEY BUSINESS PARK  
    
    LEASE  
    FROM  
    HUB PROPERTIES TRUST,
  a Maryland Real Estate Investment Trust,  
    
    TO  
    
    DEXCOM, INC,
  a Delaware corporation.

    
    5555 Oberlin Drive
  San Diego, California 92121  

   TABLE OF CONTENTS  

	 
	 	 
	 	 
	 	Page

	Article	 	1	 	Reference Data	 	1
	 	 	1.1	 	Introduction and Subjects Referred To	 	1
	 	 	1.2	 	Exhibits	 	2
	Article	 	2	 	Premises and Term	 	2
	 	 	2.1	 	Premises	 	2
	 	 	2.2	 	Term	 	3
	 	 	2.3	 	Extension Option	 	3
	 	 	2.4	 	Measurement of the Premises	 	5
	 	 	2.5	 	Right to Lease Additional Space	 	5
	Article	 	3	 	Commencement and Condition	 	6
	 	 	3.1	 	Commencement	 	6
	 	 	3.2	 	Condition of Premises	 	6
	 	 	3.3	 	Preparation of the Premises by Tenant	 	7
	 	 	3.4	 	Construction Representatives	 	8
	Article	 	4	 	Rent, Additional Rent, Insurance and Other Charges	 	8
	 	 	4.1	 	The Annual Fixed Rent	 	8
	 	 	4.2	 	Additional Rent	 	9
	 	 	4.3	 	Real Estate Taxes	 	9
	 	 	4.4	 	Operating Costs	 	10
	 	 	4.5	 	Personal Property and Sales Taxes	 	12
	 	 	4.6	 	Insurance	 	12
	 	 	4.7	 	Utilities	 	14
	 	 	4.8	 	Late Payment of Rent	 	14
	 	 	4.9	 	Security Deposit	 	14
	Article	 	5	 	Landlord's Covenants	 	16
	 	 	5.1	 	Common Area Maintenance and Lighting	 	16
	 	 	5.2	 	Water	 	16
	 	 	5.3	 	Repairs	 	16
	 	 	5.4	 	Repair Cost Waiver	 	16
	 	 	5.5	 	Interruption	 	16
	 	 	5.6	 	Outside Services	 	17
	 	 	5.7	 	Access to Building	 	17
	 	 	5.8	 	Parking	 	17
	Article	 	6	 	Tenant's Additional Covenants	 	18
	 	 	6.1	 	Affirmative Covenants	 	18
	 	 	6.2	 	Negative Covenants	 	21
	Article	 	7	 	Casualty or Taking	 	29
	 	 	7.1	 	Termination	 	29
	 	 	7.2	 	Restoration	 	29
	 	 	7.3	 	Award	 	29
	 	 	7.4	 	Termination Waiver	 	30
	Article	 	8	 	Defaults	 	30
	 	 	8.1	 	Default of Tenant	 	30
	 	 	8.2	 	Remedies	 	31
	 	 	8.3	 	Remedies Cumulative	 	32
	 	 	8.4	 	Landlord's Right to Cure Defaults	 	32
	 	 	8.5	 	Holding Over	 	32
	 	 	 	 	 	 	 

i

 

	 	 	8.6	 	Effect of Waivers of Default	 	32
	 	 	8.7	 	No Waiver, etc	 	33
	 	 	8.8	 	No Accord and Satisfaction	 	33
	Article	 	9	 	Rights of Holders	 	33
	 	 	9.1	 	Rights of Mortgagees or Ground Lessors	 	33
	 	 	9.2	 	Modifications	 	34
	 	 	9.3	 	Non-Disturbance	 	34
	Article	 	10	 	Miscellaneous Provisions	 	34
	 	 	10.1	 	Notices	 	34
	 	 	10.2	 	Quiet Enjoyment; Landlord's Right to Make Alterations, Etc	 	34
	 	 	10.3	 	Lease Not to be Recorded; Confidentiality of Lease Terms	 	35
	 	 	10.4	 	Assignment of Rents and Transfer of Title; Limitation of Landlord's Liability	 	35
	 	 	10.5	 	Landlord's Default	 	36
	 	 	10.6	 	Notice to Mortgagee and Ground Lessor	 	36
	 	 	10.7	 	Building or Complex Name Change	 	37
	 	 	10.8	 	Waiver of Jury Trial	 	37
	 	 	10.9	 	Brokerage	 	37
	 	 	10.10	 	OSHPAD Requirements	 	37
	 	 	10.11	 	Applicable Law and Construction	 	37

ii

Article 1 

Reference Data  

        1.1    Introduction and Subjects Referred To.    

        This
is a lease (this "Lease") entered into by and between Hub Properties Trust, a Maryland real estate investment trust
("Landlord") and DexCom, Inc., a Delaware corporation ("Tenant"). 

        Each
reference in this Lease to any of the following terms or phrases shall be construed to incorporate the corresponding definition stated in this Section 1.1. 

	

 	
 	

Date of this Lease:	
 	

December 3, 2003.
	

 	
 	

Complex:	
 	

The four (4) buildings (the "Buildings") of the Sorrento Valley Business Park with addresses of 5555, 5601, 5626 and 5627 Oberlin Drive, San Diego, California and the parking facilities and all
other appurtenances, and the land parcels on which they are located and the sidewalks adjacent thereto.
	

 	
 	

Building:	
 	

That certain building in the Complex with an address of 5555 Oberlin Drive, San Diego, California 92121.
	

 	
 	

Premises:	
 	

The entire rentable area of the Building, substantially as shown on Exhibit A hereto.
	

 	
 	

Premises Rentable	
 	

Area: 23,099 square feet.
	

 	
 	

Complex Rentable Area:	
 	

105,203 square feet.
	

 	
 	

Original Term:	
 	

The period commencing on the Commencement Date (as defined in Section 3.1) and expiring on the day preceding the seventh (7th) anniversary of the Rent Commencement Date, except that if the Rent Commencement Date shall occur on a day
other than the first day of a month, the Original Term shall expire on the last day of the month in which such anniversary shall occur.
	

 	
 	

Rent Commencement Date:	
 	

Four (4) months after the Commencement Date (for example, if the Commencement Date is January 9, 2004, the Rent Commencement Date shall be May 9, 2004).
	

 	
 	

Annual Fixed Rent:	
 	

The following amounts:

	
 
	
 	

 
	
 	

Year
 
	
 	

Rate

(per s.f. of Premises

Rentable Area per month)
	
 	

Annual
	
 	

Monthly
	
 	

 

	 	 	 	 	1	 	$	1.18	 	$	327,081.84	 	$	27,256.82	 	 
	 	 	 	 	2	 	$	1.22	 	$	338,169.36	 	$	28,180.78	 	 
	 	 	 	 	3	 	$	1.25	 	$	346,485.00	 	$	28,873.75	 	 
	 	 	 	 	4	 	$	1.29	 	$	357,572.52	 	$	29,797.71	 	 
	 	 	 	 	5	 	$	1.33	 	$	368,660.04	 	$	30,721.67	 	 
	 	 	 	 	6	 	$	1.37	 	$	379,747.56	 	$	31,645.63	 	 
	 	 	 	 	7	 	$	1.41	 	$	390,835.08	 	$	32,569.59	 	 

 

	

 	
 	

 	
 	

For purposes of the timing of the adjustments in the amount of Annual Fixed Rent during the Original Term, the first "Year" shall be the period beginning on the Rent Commencement Date and ending on the
day preceding the first anniversary of the Rent Commencement Date, with each succeeding Year being the twelve (12) month period following the preceding Year, except that the last year shall include any partial month from the seventh anniversary
of the Commencement Date through the last day of the Original Term and Tenant shall pay Annual Fixed Rent for such partial month the Rate for Year 7.
	

 	
 	

Tenant's Percentage:	
 	

Twenty one and 96/100 percent (21.96%), being the ratio of the Premises Rentable Area to the Complex Rentable Area.
	

 	
 	

Permitted Uses:	
 	

General office uses, biomedical research and development, biomedical manufacturing in accordance with Good Manufacturing Practices, and such other uses as are permitted under existing zoning and other laws applicable to the Complex, subject to the
provisions of Section 6.2.
	

 	
 	

Security Deposit:	
 	

$200,000.
	

 	
 	

Commercial General Liability Insurance Limits:	
 	

$3,000,000 per occurrence (combined single limit) for property damage, bodily and personal injury and death.
	

 	
 	

Original Address of Landlord:	
 	

c/o REIT Management & Research LLC

5627 Oberlin Drive

San Diego, CA 92121

Attention: Area Manager
	

 	
 	

Landlord's Agent:	
 	

REIT Management & Research LLC

or such other entity as shall be designated by Landlord from time to time.
	

 	
 	

Original Address of Tenant:	
 	

6725 Mesa Ridge Road

Suite 100

San Diego, CA 92121

        1.2    Exhibits.    The Exhibits listed below are incorporated in this Lease by reference and are to be construed as a
part of this Lease. 

	

 	
 	

EXHIBIT A.	
 	

Plan showing the Premises.
	 	 	EXHIBIT A-1.	 	Plan showing the Parking Spaces.
	 	 	EXHIBIT B.	 	Rules and Regulations.
	 	 	EXHIBIT C.	 	Alterations Requirements.
	 	 	EXHIBIT D.	 	Contractor's Insurance Requirements.
	 	 	EXHIBIT E.	 	Clerk's Certificate.
	 	 	EXHIBIT F.	 	Description of Demolition Work.
	 	 	EXHIBIT G.	 	Description of Limited Phase II Environmental Site Assessment.

Article 2 

Premises and Term  

        2.1    Premises.    Landlord hereby leases to Tenant and Tenant hereby leases from Landlord, subject to and with the
benefit of the terms, covenants, conditions and provisions of this Lease, the Premises, 

2

 

excluding
the exterior of the Building and any pipes, conduits, wires and appurtenant fixtures or equipment serving the Premises together with other portions of the Building or Complex. 

        Tenant
shall have, as appurtenant to the Premises, rights to use, in common with others, subject to reasonable rules of general applicability to tenants of the Complex from time to time
made by Landlord of which Tenant is given notice: (a) the common pipes, conduits, wires and appurtenant fixtures of the Complex serving the Premises, and (b) the common walkways and
driveways (if any) necessary for access to the Building. 

        2.2    Term.    The term of this Lease shall be for a period beginning on the Commencement Date (as defined in
Section 3.1) and continuing for the Original Term and any extension of the term hereof in accordance with the provision of this Lease, unless sooner terminated as hereinafter provided. When the
Commencement Date has been determined, such date shall be evidenced by a document executed by Landlord and Tenant and delivered each to the other, but the failure of Landlord and Tenant to execute or
deliver such document shall have no effect upon such date. The Original Term and any extension of the term hereof in accordance with the provisions of this Lease is hereinafter referred to as the
"term" of this Lease. 

        2.3    Extension Option.    So long as at the time of the Option Notice there exists no Default of Tenant (or Landlord
shall have waived such condition in its sole discretion), this Lease is still in full force and effect, and the named Tenant as set forth in Section 1.1 (or any successor by merger) and/or any
Affiliate shall actually occupy the entire Premises, Tenant shall have the right to extend the term of this Lease for one (1) additional period of five (5) years (the
"Extended Term"). The Extended Term shall commence on the day succeeding the expiration of the Original Term and shall end on the day immediately
preceding the fifth anniversary of the commencement of the Extended Term. All of the terms, covenants and provisions of this Lease applicable immediately prior to the expiration of the Original Term
shall apply to the Extended Term except that (i) the Annual Fixed Rent for the Extended Term shall be the Market Rate (as hereinafter defined) for the Premises determined as of the commencement
of the Extended Term, as designated by Landlord by notice to Tenant ("Landlord's Notice"), but subject to Tenant's right to dispute as hereinafter
provided, and (ii) Tenant shall have no further right to extend the term of this Lease beyond the Extended Term hereinabove provided. If
Tenant shall elect to exercise the aforesaid option, it shall do so by giving Landlord notice of its election (the "Option Notice") not later than nine
(9) months, nor sooner than twelve (12) months, prior to the expiration of the Original Term. Such Option Notice shall request Landlord's determination of the Market Rate within thirty
(30) days and shall apply to the entire Premises and shall be unconditional and irrevocable by Tenant except as hereinafter provided. If Tenant fails to give the Option Notice to Landlord, the
term of this Lease shall automatically terminate no later than the end of the Original Term, and Tenant shall have no further option to extend the term of this Lease, it being agreed that time is of
the essence with respect to the giving of the Option Notice. If Tenant shall extend the term hereof pursuant to the provisions of this Section 2.3, such extension shall be automatically
effected without the execution of any additional documents, but Landlord and Tenant shall, at the request of either, execute an amendment to this Lease, in a commercially reasonable form prepared by
Landlord, confirming such extension of the term and the Annual Fixed Rent for the Extended Term. 

        "Market Rate" shall mean the then annual rental rate and terms for the Premises for the Extended Term (determined as set forth below).
Landlord shall give Tenant Landlord's Notice not later thirty (30) days after Tenant gives an Option Notice. If Tenant disagrees with the Market Rate designated in Landlord's Notice, Tenant
shall notify Landlord of such disagreement and of Tenant's designation of the Market Rate by notice given not later than fifteen (15) days after the giving of Landlord's Notice, and if Tenant
fails to so notify Landlord, then the Market Rate shall be as designated in Landlord's Notice and such designation shall be final and conclusive. If Tenant notifies Landlord that it disagrees with
Landlord's designation of Market Rate within such fifteen (15) day period and the parties cannot agree upon the Market Rate by the date that is thirty (30) days following Landlord's
Notice, then 

3

 

Tenant
shall have the right to withdraw and cancel the Option Notice by giving written notice thereof to Landlord on or before the date that is thirty (30) days after the giving of Landlord's
Notice, but if Tenant fails to notify Landlord of its decision to withdraw and cancel the Option Notice within such time period, then the Option Notice shall become binding and irrevocable and the
Market Rate shall be determined by appraisal as follows: Within fifteen (15) days after the expiration of such thirty (30) day period, Landlord and Tenant shall each give notice to the
other specifying the name and address of the appraiser each has chosen. The two appraisers so chosen shall meet within ten (10) days after the second appraiser is appointed and if, within
twenty (20) days after the second appraiser is appointed, the two appraisers shall not agree upon a determination of the Market Rate in accordance with the following provisions of this
Section 2.3, they shall together appoint a third appraiser. If only one appraiser shall be chosen whose name and address shall have been given to the other party within such fifteen
(15) day period and who shall have the qualifications hereinafter set forth, that sole appraiser shall render the decision which would otherwise have been made as hereinabove provided. 

        If
said two appraisers cannot agree upon the appointment of a third appraiser within ten (10) days after the expiration of such twenty (20) day period, then either party,
on behalf of both and on notice to the other, may request such appointment by the American Arbitration Association (or any successor organization) in accordance with its then prevailing rules. In the
event that all three appraisers cannot agree upon such Market Rate within ten (10) days after the third appraiser shall have been selected, then each appraiser shall submit his or her
designation of such Market Rate to the other two appraisers in writing; and Market Rate shall be determined by calculating the average of the two numerically closest (or, if the values are
equidistant, all three) values so determined. 

        Each
of the appraisers selected as herein provided shall have at least ten (10) years experience as a commercial real estate broker in the city of San Diego dealing with
properties of the same type and quality as the Building. Each party shall pay the fees and expenses of the appraiser it has selected and the fees of its own counsel, witnesses and similar expenses.
Each party shall pay one half (1/2) of the fees and expenses of the third appraiser (or the sole appraiser, if applicable) and all other expenses of the appraisal. The decision and award of the
appraiser(s) shall be in writing and shall be final and conclusive on all parties, and counterpart copies thereof shall be delivered to both Landlord and Tenant. Judgment upon the award of the
appraiser(s) may be entered in any court of competent jurisdiction. 

        Both
appraisers or a majority of them (or the sole appraiser, if applicable) shall determine the Market Rate of the Premises for the applicable period as of the commencement of the
Extended Term and render a decision and award as to their determination to both Landlord and Tenant (a) within twenty (20) days after the appointment of the second appraiser,
(b) within twenty (20) days after the appointment of the third appraiser or (c) within fifteen (15) days after the appointment of the sole appraiser, as the case may be. In
rendering such decision and award, the appraiser(s) shall assume (i) that the Premises are available in the then rental market, (ii) that Landlord has had a reasonable time to locate a
tenant, (iii) that neither Landlord nor the prospective tenant is under a compulsion to rent, (iv) that Landlord and Tenant are typically motivated, well-informed and
well-advised, and each is acting in what it considers its own best interest, (v) the Premises (w) are fit for immediate occupancy and use "as is", (x) require no
additional work by Landlord or Tenant, (y) are appropriate and desired for immediate occupancy by Tenant, and (z) contain no work that has been carried out thereon by Tenant, its
subtenant(s), or its or their successors-in-interest during the Original Term which has diminished the rental value of the Premises, and (vi) that in the event the
Premises are destroyed or damaged by fire or other casualty prior to the commencement of the Extended Term, they have been fully restored. The appraisers shall also take into consideration any
increases or possible increases in rent then being included in leases for comparable space in the Building or in comparable buildings based on changes in price indices, including cost of living, or
periodic market rental adjustments. In rendering such decision and award, the appraiser(s) shall consider the market fixed annual rents then being charged for comparable space in comparable buildings
in the city of San Diego, but shall not modify the provisions of this Lease. 

4

 

        If
the dispute between the parties as to the Market Rate has not been resolved before the commencement of Tenant's obligation to pay the Annual Fixed Rent based upon determination of
such Market Rate, then Tenant shall pay the Annual Fixed Rent under the Lease based upon the Market Rate designated by Landlord in Landlord's Notice until either the agreement of the parties as to the
Market Rate, or the decision of the appraiser(s), as the case may be, at which time Tenant shall pay any underpayment of the Annual Fixed Rent to Landlord, or Landlord shall refund any overpayment of
the Annual Fixed Rent to Tenant. 

        Landlord
and Tenant hereby waive the right to an evidentiary hearing before the appraiser(s) and agree that the appraisal shall not be an arbitration nor be subject to state or federal
law relating to arbitrations. 

        2.4    Measurement of the Premises.    Landlord and Tenant agree that the Premises Rentable Area identified in
Section 1.1 is recited for Landlord's administrative purposes only and that, although the Annual Fixed Rent and the Tenant's Percentage has been determined by reference to such square footage
(regardless of the possibility that the actual measurement of the Premises may be more or less than the number identified, irrespective of measurement method used), Annual Fixed Rent and Tenant's
Percentage shall not be changed except as expressly provided in this Lease. 

        2.5    Right to Lease Additional Space.    So long as (i) there then exists no Default of Tenant,
(ii) the Tenant named in Section 1.1 of this Lease (or any successor by merger) and/or any Affiliate shall occupy the entire Premises, and (iii) this Lease is still in full force
and effect, then if any space in the building located at 5601 Oberlin Drive, San Diego, CA shall become available for lease by Landlord, Landlord shall so notify Tenant, and shall identify the space
available (the "Offered Space") and the date on which such Offered Space is expected to be available, and Tenant may, by giving notice to Landlord
within ten (10) days after receipt of such notice, irrevocably elect to lease the Offered Space on the terms of this Section 2.5. If Tenant shall have so elected to lease the Offered
Space, it shall enter into an amendment to this Lease within ten (10) days after it shall have received the same from Landlord, confirming the lease of such Offered Space to Tenant pursuant to
the terms hereof, such amendment to be in a commercially reasonable form prepared by Landlord. If Tenant shall not elect to lease the Offered Space within the aforesaid 10-day period, then
Landlord shall thereafter be free to lease any or all of such Offered Space to a third party or parties from time to time on such terms and conditions as it may deem appropriate. 

        Tenant
shall lease the Offered Space subject to all of the terms, covenants and agreements of this Lease in effect from and after the date on which the Offered Space becomes a part of
the Premises, except that (i) the Annual Fixed Rent for the Offered Space shall be the Market Rate for the Offered Space, (ii) Tenant's Percentage shall be adjusted to reflect the
expansion of the Premises to include the Offered Space, and (iii) if the Offered Space shall become available for lease as of a date on which there are less than three (3) years
remaining in the term of this Lease (excluding any unexercised option to extend), then the term with respect to the Offered Space shall be the term for which Landlord intends to offer such space to
third parties (which need not be co-terminus with that applicable to the Premises then demised to Tenant under the Lease). Landlord shall designate the Market Rate and, if applicable, the
term for the Offered Space, in Landlord's notice to Tenant of the availability of the Offered Space. If Tenant shall elect to lease the Offered Space but shall disagree with Landlord's designation of
the Market Rate, then Tenant shall so notify Landlord of such disagreement in Tenant's notice electing to lease the Offered Space, otherwise the Market Rate for the Offered Space shall be as
designated by Landlord. If Tenant disagrees timely with Landlord's designation of the Market Rate for the Offered Space and the parties cannot agree upon the Market Rate within ten (10) days
after Tenant's notice, the Market Rate for the Offered Space shall be determined in the manner provided in Section 2.3. Subject to Landlord's obligations under Article 5, Tenant shall
lease the Offered Space in "as is" condition, and Landlord shall not be required to construct any leasehold improvements to the Offered Space or to provide Tenant with any financial contribution for
such purpose. Landlord and Tenant agree that time shall be of the essence of this Section 2.5. 

5

 

        The
provisions of this Section 2.5 shall not apply, and space shall not be deemed "available for lease" hereunder, if Landlord shall intend either (a) to enter into a lease
of such space to any party pursuant to the terms of a lease in effect as of the Date of this Lease or to any entity controlling, controlled by or under common control with Landlord, or (b) to
renew or extend the lease with (or grant a new lease to) the entity (or any party affiliated with such entity) then occupying such space. 

Article 3 

Commencement and Condition  

        3.1    Commencement.    The "Commencement Date" shall be the date that
is five (5) "Business Days" (i.e., weekdays that are not holidays of the federal government) after the date (the
"Completion Date") on which all of the work required to be performed pursuant to Section 3.2 has been completed and Landlord has delivered to
Tenant the Final Phase II Assessment. The "Final Phase II Assessment" shall mean the Limited Phase II Environmental Site Assessment described in
Exhibit G, as supplemented by any additional environmental assessments performed pursuant to Section 3.2. Notwithstanding the foregoing, if Tenant is not satisfied with the Final Phase
II Assessment for any reason in Tenant's sole discretion, then Tenant shall have the right to terminate this Lease by giving notice to Landlord not
later than the expiration of such five (5) Business Day period; and this Lease shall cease and come to an end without further liability or obligation on the part of either party upon the giving
of such notice, it being agreed that time is of the essence with respect to the giving of such notice. 

        Landlord
shall use all reasonable efforts to cause the Completion Date to occur by January 1, 2004. If the Completion Date has not occurred by January 15, 2004, then Tenant
shall have the right to terminate this Lease by giving notice to Landlord at any time after January 15, 2004 but before the occurrence of the Completion Date; and this Lease shall cease and
come to an end without further liability or obligation on the part of either party upon the giving of such notice, it being agreed that time is of the essence with respect to the giving of such
notice. The foregoing termination right shall be Tenant's sole and exclusive remedy at law or in equity for Landlord's failure to cause the Completion Date to occur by any date, and if Tenant shall
not exercise such right before the occurrence of the Completion Date, then Tenant shall have no right to terminate this Lease due to any delay in the occurrence of the Completion Date. 

        3.2    Condition of Premises.    Landlord shall complete, or cause others to complete, the demolition work in the
Premises described in Exhibit F (the "Demolition Work"). After the Demolition Work has been completed, Occupational Services, Inc. shall
perform a Limited Phase II Environmental Site Assessment of the Premises and certain areas adjacent to the Building, as described in Exhibit G, a complete copy of which shall be delivered to
Tenant. If, based on the conclusions in such Limited Phase II Environmental Site Assessment, any remediation work is required to bring the Premises or other areas covered by such assessment into
compliance with Environmental and Health Laws (as defined in Section 6.2.8), then Landlord (i) may terminate this Lease if Landlord determines, in its sole discretion, that the
contamination requiring remediation is significant, by notice given to Tenant within ten (10) Business Days after delivery of the Limited Phase II Environmental Site Assessment, and this Lease
shall cease and come to an end without further liability or obligation on the part of either party upon the giving of such notice, or if Landlord shall not so elect to terminate this Lease,
(ii) shall perform, or cause others to perform, all such remediation work, and cause such additional environmental assessments to be performed as are necessary to establish that such work has
been completed and that no additional remediation work is required. If the Limited Phase II Environmental Site Assessment does not indicate that any remediation work is required, then the Limited
Phase II Environmental Site Assessment shall be the Final Phase II Assessment. 

        Subject
to completion of the Demolition Work and any remediation work required by the preceding paragraph, Tenant agrees to accept delivery of the Premises in the condition existing as
of the Date of this Lease. Tenant acknowledges that it has been given an adequate opportunity to inspect 

6

 

the
Premises and the common areas and facilities of the Complex and, subject to the completion of any work required to be performed by Landlord pursuant to the preceding sentence, has found the
condition of both satisfactory and is not relying on any representations of Landlord or Landlord's agents or employees as to such condition, and Landlord shall have no obligation with respect thereto
except as may be expressly set forth in this Lease. 

        3.3    Preparation of the Premises by Tenant.    (a) Tenant, at Tenant's sole cost and expense except to the
extent of Landlord's Contribution (hereinafter defined), shall be responsible for making all alterations or improvements to the Premises required or desired by Tenant, subject to Landlord's approval,
as hereinafter provided. The initial alterations and improvements to be made by Tenant to prepare the Premises for Tenant's occupancy are hereinafter referred to as "Tenant's
Work". Promptly after the Date of this Lease, Tenant shall prepare plans and specifications for Tenant's Work ("Tenant's Plans")
in accordance with the requirements of Exhibit C attached hereto. Tenant's Plans shall be subject to review and approval by Landlord as provided in Exhibit C and this Section 3.3,
such approval not to be unreasonably withheld, conditioned or delayed. Failure by Landlord to respond to Tenant's Plans or any resubmission thereof (either by disapproval, request for additional
information, request for revision or communication of a reason for failure to approve) within ten (10) Business Days after the date of Landlord's receipt of Tenant's Plans or any such
resubmission shall constitute approval thereof, provided, however that no such automatic approval shall occur unless Tenant's submission contains the following notice, printed in a prominent place on
the outside thereof in not less fourteen (14) point bold-faced type: "LANDLORD REVIEW REQUIRED; FAILURE TO RESPOND TO THIS SUBMISSION WITHIN TEN
(10) BUSINESS DAYS SHALL RESULT IN AUTOMATIC APPROVAL PURSUANT TO LEASE SECTION 3.3."

        (b)   Upon
approval of Tenant's Plans by Landlord, Tenant shall cause its contractor(s) to perform Tenant's Work in accordance with Tenant's Plans, diligently and continuously
until Tenant's Work is substantially complete. Tenant's Work shall be performed in accordance with the requirements of Exhibit C and the applicable provisions of Article 6, and Tenant
shall be responsible for all construction management. 

        (c)   Tenant's
Work shall be considered substantially complete and the "Substantial Completion Date" shall occur on the first
day that all of the following requirements have been met: (i) all work shown and described in Tenant's Plans, and any modifications thereto approved by Landlord, has been completed, with only
punchlist items (i.e., minor details of decoration or mechanical adjustment) excepted; (ii) Tenant's architect has issued a certificate of substantial completion on the standard AIA form, which
has been delivered to Landlord; (iii) all electrical, mechanical, plumbing and HVAC facilities installed by Tenant are functioning properly; (iv) the Premises are reasonably free of
debris and construction materials, (v) all required governmental inspections have been successfully completed and a certificate of occupancy has been issued permitting occupancy and use of the
Premises by Tenant for the Permitted Uses; and (vi) Tenant has obtained and delivered to Landlord all of the documents listed in Paragraph H of Exhibit C. 

        (d)   Provided
this Lease is in full force and effect, then, subject to the provisions of the following paragraph, Landlord will provide Tenant with an improvement allowance
(the "Landlord's Contribution") equal to the lesser of (i) $646,772.00, or (ii) the actual cost of Tenant's Work, as evidenced by the
invoices submitted by Tenant establishing such cost. For purposes of this Section 3.3, the "cost" of Tenant's Work shall mean all fees and
expenses of Tenant's architectural and engineering professionals in connection with Tenant's Work; all contractor charges for labor, materials, general conditions and contractor's overhead and profit;
permitting fees; and fees paid to independent construction managers, if any. 

7

   
        (e)   Tenant may requisition Landlord for payment of Landlord's Contribution, in one or more installments, but not more often than once per calendar month, provided that
Landlord may withhold ten percent (10%) of the amount of each requisition paid prior to the Substantial Completion Date (hereinafter "Progress
Payments") until the Final Payment (hereinafter defined). Each requisition for a Progress Payment shall include (i) a detailed breakdown of the costs of Tenant's Work
and other reimbursable costs incurred to the date of the requisition, (ii) a copy of each Application for Payment from Tenant's contractor for the contractor's costs and charges to be
reimbursed by the Progress Payment, (iii) copies of invoices from Tenant's architect, supplier(s) and others, as applicable, for all costs of Tenant's Work (to the extent not submitted with a
prior requisition), (iv) a copy of the Certificate for Payment (substantially on the AIA form) issued by Tenant's Architect with respect to the contractor's Application for Payment, including a
certification from Tenant's architect that all of the construction work to be reimbursed by the Progress Payment has been completed in accordance with the approved Tenant's Plans, and
(v) waivers and releases of liens from all parties providing labor or materials covering the work to be paid for by the Progress Payment and all prior work. Landlord shall make each Progress
Payment to Tenant within thirty (30) days after Landlord's receipt of a Progress Payment requisition with all required supporting documentation, unless, within such period, Landlord notifies
Tenant of its rejection of all or part of such requisition, specifying the reasons therefor. If Landlord so notifies Tenant, then Landlord shall pay to Tenant all amounts as to which Landlord does not
make objection, and shall pay to Tenant the amounts withheld by Landlord within ten (10) Business Days after reasonable satisfaction of such objections. 

        (f)    After
the occurrence of the Substantial Completion Date, Tenant may submit a requisition to Landlord for payment of the balance of Landlord's Contribution and all
retained amounts (the "Final Payment"). Such requisition shall include (i) a final, detailed breakdown of all of the costs of Tenant's Work and
other reimbursable costs, (ii) all of the documentation required by clauses (ii), (iii) (iv) and (v) of the preceding paragraph to the extent not previously provided, and
(iii) a certification from Tenant's chief financial officer that Tenant has made full payment for all of the work and other items covered by the prior Progress Payments. Landlord shall make the
Final Payment to Tenant as provided in the last two sentences of the preceding paragraph. 

        (g)   Notwithstanding
any provision of this Section 3.3 to the contrary, Landlord shall not be required to make payment of Landlord's Contribution with respect to any
requisition (whether for a Progress Payment or the Final Payment) submitted later than three hundred and sixty (360) days after the Date of this Lease or at any time there exists a Default of
Tenant (as defined in Section 8.1). 

        3.4    Construction Representatives.    Both Landlord and Tenant shall appoint one individual as its
"Construction Representative" who is authorized to act on its behalf in connection with any matters arising pursuant to this Article 3. The
Construction Representative may be changed from time to time by notice hereunder from the then current Construction Representative to the other party's Construction Representative or by notice from
Landlord or Tenant pursuant to Section 10.1. The initial
Construction Representatives shall be Lynn Schemmel (Landlord) and Steven Kemper (Tenant). Notwithstanding Section 10.1, any notices or other communication under this Article 3 may be
made by letter or other writing sent by U.S. mail, facsimile or email, provided the communication is made by one party's Construction Representative to the other party's Construction Representative. 

Article 4 

Rent, Additional Rent, Insurance and Other Charges

        4.1    The Annual Fixed Rent.    Tenant's obligation to pay Annual Fixed Rent shall begin on the Rent Commencement
Date. Tenant shall pay Annual Fixed Rent to Landlord, or as otherwise directed by Landlord, without offset, abatement (except as provided in Article 7), deduction or demand. Annual Fixed Rent
shall be payable in equal monthly installments, in advance, on the first day of each and 

8

 

every
calendar month during the term of this Lease, at the Original Address of Landlord, or at such other place as Landlord shall from time to time designate by notice, by check drawn on a domestic
bank. 

        Annual
Fixed Rent for any partial month shall be prorated on a daily basis (based on a 365 day year), and if Annual Fixed Rent commences on a day other than the first day of a
calendar month, the first payment which Tenant shall make to Landlord shall be payable on the date Annual Fixed Rent commences and shall be equal to such prorated amount plus the instalment of Annual
Fixed Rent for the succeeding calendar month. 

        4.2    Additional Rent.    Tenant covenants and agrees to pay Tenant's Percentage (21.96% as of the Date of this
Lease) of Taxes and Operating Costs as provided in Section 4.3 and 4.4, and all other charges and amounts payable by or due from Tenant to Landlord (all such amounts referred to in this
sentence being "Additional Rent"). Notwithstanding any provision of Section 4.3 or 4.4 to the contrary, Tenant's obligation to pay Tenant's
Percentage of Taxes and Operating Costs as provided in Sections 4.3 and 4.4 shall commence on Rent Commencement Date. 

        4.3    Real Estate Taxes.    Tenant shall pay to Landlord, as Additional Rent, an amount
("Tenant's Tax Share") equal to Tenant's Percentage of the Taxes (as hereinafter defined) due (or estimated to be due by governmental authority) for any
fiscal tax period (a "Tax Year") during the term hereof. Except as otherwise provided in the immediately following paragraph, Tenant shall pay Tenant's
Tax Share to Landlord at least ten (10) days prior to the date or dates within any year during the term hereof that
the same, or any fractional share thereof, shall be due and payable to any governmental authority responsible for collection of same (as stated in a written notice to Tenant given at least twenty
(20) days prior to the date or dates any such payment shall be due, which notice shall set forth the manner of computation of any Tenant's Tax Share due from Tenant), except that such payment
shall be made to Landlord not later than ten (10) days after such notice to Tenant, if such notice is given subsequent to the date twenty (20) days prior to the date the same is due and
payable as aforesaid. 

        At
Landlord's election, Tenant shall pay to Landlord, as Additional Rent on the first day of each calendar month during the term but otherwise in the manner provided for the payment of
Annual Fixed Rent, estimated payments on account of Tenant's Tax Share, such monthly amounts to be sufficient to provide Landlord by the time Tax payments are due or are to be made by Landlord a sum
equal to Tenant's Tax Share, as reasonably estimated by Landlord from time to time on account of Taxes for the then current Tax Year. If the total of such monthly remittances for any Tax Year is
greater than Tenant's Tax Share for such Tax Year, Landlord shall credit such overpayment against Tenant's subsequent obligations on account of Taxes (or promptly refund such overpayment if the term
of this Lease has ended and Tenant has no further obligations to Landlord); if the total of such remittances is less than Tenant's Tax Share for such Tax Year, Tenant shall pay the difference to
Landlord within ten (10) days after being so notified by Landlord. 

        If,
after Tenant shall have made all payments due to Landlord pursuant to this Section 4.3, Landlord shall receive a refund of any portion of Taxes as a result of an abatement of
such Taxes by legal proceedings, settlement or otherwise (without either party having any obligation to undertake any such proceedings), Landlord shall pay or credit to Tenant Tenant's Percentage of
that percentage of the refund (after first deducting any expenses, including attorneys', consultants' and appraisers' fees, incurred in connection with obtaining any such refund) which equals the
percentage of the applicable Tax Year included in the term hereof, provided however, in no event shall Tenant be entitled to receive more than the sum of payments actually made by Tenant on account of
Taxes with respect to such Tax Year. 

        In
the event that the Commencement Date shall occur or the term of this Lease shall expire or be terminated during any Tax Year, or should the Tax Year or period of assessment of real
estate taxes be changed or be more or less than one (1) year, or should Tenant's Percentage be modified during any 

9

 

Tax
Year due to a change in the rentable area of the Building and/or the Premises or otherwise, as the case may be, then the amount of Tenant's Tax Share which may be otherwise payable by Tenant as
provided in this Section 4.3 shall be pro-rated on a daily basis based on a 365 day Tax Year. 

        The
term "Taxes" shall mean all taxes, assessments, excises and other charges which are general or special, ordinary or extraordinary,
foreseen or unforeseen, of any kind or nature which are levied, assessed or imposed at any time during the term by any governmental authority upon or against the Complex, or taxes in lieu thereof, and
additional types of taxes to supplement real estate taxes due to
legal limits imposed thereon. If, at any time during the term of this Lease, any tax or excise on rents or other taxes, however described, are levied or assessed against Landlord, either wholly or
partially in substitution for, or in addition to, real estate taxes then assessed or levied on the Complex, such tax or excise on rents shall be included in Taxes; however, Taxes shall not include
franchise, estate, inheritance, succession, capital levy, income or excess profits taxes assessed on Landlord or taxes or penalties specifically assessed against other tenants of the Complex. Taxes
also shall include all court costs, attorneys', consultants' and accountants' fees, and other expenses incurred by Landlord contesting Taxes through and including all appeals. Taxes shall include any
estimated payment made by Landlord on account of a fiscal tax period for which the actual and final amount of taxes for such period has not been determined by the governmental authority as of the date
of any such estimated payment. 

        Tenant
shall also pay to Landlord, upon demand, as Additional Rent, such portion of all Taxes levied or assessed against Landlord or the Complex which are attributable to the value of
any leasehold improvements installed by or on behalf of Tenant in the Premises. 

        4.4    Operating Costs.    Tenant shall pay to Landlord, as Additional Rent, an amount
("Tenant's Operating Cost Share") equal to Tenant's Percentage of Operating Costs (as hereinafter defined) paid or incurred by Landlord in any
twelve-month period established by Landlord (an "Operating Year"). Except as otherwise provided in the immediately following paragraph Tenant shall pay
Tenant's Operating Cost Share to Landlord within twenty (20) days from the date Landlord shall furnish to Tenant an itemized year-end statement thereof, prepared, allocated and
computed in accordance with then prevailing customs and practices of the real estate industry in the San Diego area, consistently applied. 

        At
the election of Landlord, Tenant shall pay to Landlord, as Additional Rent on the first day of each calendar month during the term but otherwise in the manner provided for the payment
of Annual Fixed Rent, estimated payments on account of Tenant's Operating Cost Share, such monthly amounts to be sufficient to provide to Landlord, by the end of each Operating Year, a sum equal to
Tenant's Operating Cost Share for such Operating Year, as reasonably estimated by Landlord from time to time during such Operating Year. If, at the expiration of each Operating Year in respect of
which monthly instalments of Tenant's Operating Cost Share shall have been made as aforesaid, the total of such monthly remittances is greater than the actual Tenant's Operating Cost Share for such
Operating Year, Landlord shall credit such overpayment against Tenant's subsequent obligations on account of Operating Costs (or promptly refund such overpayment if the term of this Lease has ended
and Tenant has no further obligation to Landlord); if the total of such remittances is less than Tenant's Operating Cost Share for such Operating Year, Tenant shall pay the difference to Landlord
within thirty (30) days after being so notified by Landlord and provided with the year-end statement of Operating Costs. 

        In
the event that the Commencement Date shall occur or the term of this Lease shall expire or be terminated during any Operating Year or Tenant's Percentage shall be modified during any
Operating Year due to a change in the rentable area of the Building and/or the Premises or otherwise, as the case may be, then the amount of Tenant's Operating Cost Share which may be payable by
Tenant as provided in this Section 4.4 shall be pro rated on a daily basis based on a 365 day Operating Year. 

        The
term "Operating Costs" shall include all costs and expenses paid or incurred for the operation, cleaning, management, maintenance,
repair, replacement, upkeep and security of the common areas 

10

 

and
common facilities and equipment of the Complex, including the structural and exterior portions of the Buildings (collectively, the "Common Areas"),
including, without limitation: 

        (a)   all
salaries, wages, fringe benefits, payroll taxes and worker's compensation insurance premiums related thereto and all other costs paid or incurred with respect to
employment of personnel engaged in operation, administration, cleaning, maintenance, repair, upkeep and security of the Common Areas, including, without limitation, supervisors, property managers,
accountants, bookkeepers, janitors, carpenters, engineers, mechanics, electricians and plumbers; 

        (b)   the
cost of utilities consumed in connection with the operation, repair and maintenance of the common areas, and the cost of water (and associated sewer charges)
provided to the Complex (including water provided to the tenants); 

        (c)   all
costs, including supplies, material and equipment costs, for cleaning the Common Areas (including, without limitation, trash removal and exterior window cleaning),
and landscaping; 

        (d)   the
cost of replacements for tools and other similar equipment used in repair, maintenance, cleaning, protection and security of the Common Areas, provided that, in the
case of any such equipment used jointly on other property of Landlord, such costs shall be suitably prorated among the Complex and such other properties; 

        (e)   all
costs and premiums for fire, casualty, rental income, liability and such other insurance as may be maintained from time to time by Landlord with respect to the
Complex and premiums for fidelity bonds covering persons having custody or control over funds or other property of Landlord; 

        (f)    all
costs of maintenance, repair, operation, administration, and protection of the Common Areas, including structural repairs and replacement of equipment (other than
repairs for which Landlord has received full reimbursement from contractors, other tenants of the Building or from others), necessary to keep the Complex in good working order, repair, appearance and
condition (including, without limitation, fees, if any, imposed upon Landlord, or charged to the Complex, by the state or municipality in which the Complex is located on account of the need for
increased or augmented public or life safety services; 

        (g)   all
costs incurred in connection with the administration and supervision of all matters referred to in items (a) through (f) hereof and in performing
Landlord's obligations under Article 5, including Landlord's office overhead costs provided that, if any such administrative or supervisory personnel are also employed on or provide service to
other property of Landlord, such cost of compensation shall be suitably prorated among the Complex and such other properties; 

        (h)   payments
under all service contracts relating to matters referred to in Items (a) through (g) hereof; 

        (i)    a
management fee of up to three percent (3%) of gross rents payable by tenants of the Complex; 

        (j)    attorney's
fees and disbursements (exclusive of any such fees and disbursements incurred in tax abatement proceedings or in the preparation of leases) and auditing and
other professional fees and expenses; and 

        (k)   CC&R
(as defined in Section 6.12) assessments and dues. 

        Notwithstanding
the foregoing, Operating Costs shall not include any costs directly related to the negligence of Landlord or any other tenant of the Complex. 

        If,
during the term of this Lease, Landlord shall make any capital expenditure (as determined in accordance with generally accepted accounting principals) that is an Operating Cost,
Landlord shall 

11

 

include
in Operating Costs for the Operating Year in which such expenditure was made and in Operating Costs for each succeeding Operating Year an annual charge-off of such capital
expenditure. Annual charge-offs shall be equal to the level payments of principal and interest necessary to amortize the original capital expenditure over the useful life of the
improvement, repair, alteration or replacement made with the capital expenditure using an interest rate reasonably determined by Landlord as being the interest rate being charged at the time of the
original capital expenditure for long-term mortgages by institutional lenders on like properties within the San Diego area; and the useful life shall be determined reasonably by Landlord
in accordance with then prevailing customs and practices of the real estate industry in the San Diego area, consistently applied. 

        In
addition, if during any portion of any Operating Year for which Operating Costs are being computed, less than ninety five percent (95%) of the rentable area of the Complex was leased
to tenants or if Landlord is supplying less than ninety five percent (95%) of the rentable area of the
Complex with the services and utilities being supplied hereunder, Landlord will reasonably project, on an item-by-item basis, the Operating Costs that would have been incurred
if one hundred percent (100%) of the Complex were occupied for such Operating Year and such services and utilities were being supplied to one hundred percent (100%) of the rentable area of the
Complex, and such projected amount shall, for the purposes hereof, be deemed to be the Operating Costs for such Operating Year. For purposes of the "gross up" provision contained in this paragraph,
Landlord shall only increase Operating Costs which by their nature vary based on the occupancy of the Complex. Landlord shall not increase those Operating Costs which by their nature are fixed
independently of the level of occupancy of the Complex. 

        4.5    Personal Property and Sales Taxes.    Tenant shall pay all taxes charged, assessed or imposed upon the personal
property of Tenant and all taxes on the sales of services or inventory, merchandise and any other goods by Tenant in or upon the Premises. 

        4.6    Insurance.    Tenant shall, at its expense, take out and maintain, from the date upon which Tenant first enters
the Premises for any reason, and throughout the term and thereafter so long as Tenant is in occupancy of any part of the Premises, the following insurance: 

        (a)   Commercial
general liability insurance (on an occurrence basis, including without limitation, broad form contractual liability, bodily injury, property damage, fire
legal liability, and products and completed operations coverage) under which Tenant is named as an insured and Landlord and Landlord's Agent (and the holder of any mortgage on the Building or the
Complex, as set out in a notice from time to time) are named (on a 1993 ISO CGL Form or its equivalent) as additional insureds as their interests may appear, in an amount which shall, at the beginning
of the term, be at least equal to the Commercial General Liability Insurance Limits, and, which, from time to time during the term, shall be for such higher limits, if any, as Landlord shall determine
to be customarily carried in the area in which the Premises are located at property comparable to the Premises and used for similar purposes; 

        (b)   Worker's
compensation insurance with statutory limits covering all of Tenant's employees working on the Premises; and 

        (c)   So-called
"special form" property insurance on a "replacement cost" basis with an agreed value endorsement covering all furniture, furnishings, fixtures and
equipment and other personal property brought to the Premises by Tenant or any party claiming under Tenant and all improvements and betterments to the Premises performed at Tenant's expense. 

        All
such policies shall contain deductibles not in excess of that reasonably approved by Landlord, shall contain a clause confirming that such policy and the coverage evidenced thereby
shall be primary with respect to any insurance policies carried by Landlord and shall be obtained from responsible companies qualified to do business and in good standing in the State of California,
which companies 

12

 

shall
have a general policy holder's rating in Best's of at least A+ X or otherwise acceptable to Landlord. A copy of each paid-up policy evidencing such insurance (appropriately
authenticated by the insurer) or a certificate (on ACORD Form 27 or its equivalent) of the insurer, certifying that such policy has been issued, providing the coverage required by this Section
and containing provisions specified herein, shall be delivered to Landlord prior to the commencement of the term of this Lease and, upon renewals, not less than thirty (30) days prior to the
expiration of such coverage. Each such policy shall be non-cancelable and not materially changed with respect to the interest of Landlord and such mortgagees of the Building or the Complex
(and others that are in privity of estate with Landlord of which Landlord provides notice to Tenant from time to time) without at least thirty (30) days' prior written notice thereto. Any
insurance required of Tenant under this Lease may be furnished by Tenant under a blanket policy carried by it provided that such blanket policy shall reference the Premises, and shall guarantee a
minimum limit available for the Premises equal to the insurance amounts required in this Lease. Landlord may, at any time, and from time to time, inspect and/or copy any and all insurance policies
required to be procured by Tenant hereunder. 

        Landlord
and Tenant shall each endeavor to secure an appropriate clause in, or an endorsement upon, each property damage insurance policy obtained by it and covering the Building, the
Premises or the personal property, fixtures and equipment located therein or thereon, pursuant to which the respective insurance companies waive subrogation or permit the insured, prior to any loss,
to agree with a third party to waive any claim it might have against said third party. The waiver of subrogation or permission for waiver of any claim hereinbefore referred to shall extend to the
agents of each party and its employees and, in the case of Tenant, shall also extend to all other persons and entities occupying or using the Premises by, through or under Tenant. If and to the extent
that such waiver or permission can be obtained only upon payment of an additional charge then the party benefiting from the waiver or permission shall pay such charge upon demand, or shall be deemed
to have agreed that the party obtaining the insurance coverage in question shall be free of any further obligations under the provisions hereof relating to such waiver or permission from such
insurance companies. 

        Subject
to the provisions of the preceding paragraph, and insofar as may be permitted by the terms of the insurance policies carried by it, each party hereby releases the other with
respect to any claim which it might otherwise have against the other party for any loss or damage excluding any deductible amounts, to the extent such damage is actually covered or would have been
covered by policies of insurance required by this Lease to be carried by the respective parties hereunder. In addition, Tenant agrees to exhaust any and all claims against its insurer(s) prior to
commencing an action against Landlord for any property loss. 

13

  

        If
this Lease is assigned or if the Premises or any part thereof are sublet (or occupied by any party other than Tenant and its employees) Landlord may collect the rents from such
assignee, subtenant or occupant, as the case may be, and apply the net amount collected to the Annual Fixed Rent and Additional Rent herein reserved, but no such collection shall be deemed a waiver of
the provisions set forth in the first paragraph of this Subsection 6.2.1, the acceptance by Landlord of such assignee, subtenant or occupant, as the case may be, as a tenant, or a release of Tenant
from the future performance by Tenant of its covenants, agreements or obligations contained in this Lease. 

        Any
sublease of all or any portion of the Premises shall provide that it is subject and subordinate to this Lease and to the matters to which this Lease is or shall be subject or
subordinate, that other than the payment of Annual Fixed Rent and Additional Rent due pursuant to Sections 4.1, 4.3 or 4.4 or any obligation relating solely to those portions of the Premises which are
not part of the subleased premises, the subtenant shall comply with and be bound by all of the obligations of Tenant hereunder, that unless Landlord waives such prohibition, the subtenant may not
enter into any sub-sublease, sublease assignment, license or any other agreement granting any right of occupancy of any portion of the subleased premises; and that Landlord shall be an
express beneficiary of any such obligations, and that in the event of termination of this Lease or reentry or dispossession of Tenant by Landlord under this Lease, Landlord may, at its option, take
over all of the right, title and interest of Tenant, as sublessor under such sublease, and such subtenant shall, at Landlord's option, attorn to Landlord pursuant to the then executory provisions of
such sublease, except that neither Landlord nor any mortgagee of the Complex, as holder of a mortgage or as Landlord under this Lease if such mortgagee succeeds to that position, shall (a) be
liable for any act or omission of Tenant under such sublease, (b) be subject to any credit, counterclaim, offset or defense which theretofore accrued to such subtenant against Tenant, or
(c) be bound by any previous modification of such sublease unless consented to by Landlord and such mortgagee or by any previous prepayment of more than one (1) month's rent,
(d) be bound by any covenant of Tenant to undertake or complete any construction of the Premises or any portion thereof, (e) be required to account for any security deposit of the
subtenant other than any security deposit actually received by Landlord, (f) be bound by any obligation to make any payment to such subtenant or grant any credits unless specifically agreed to
by Landlord and such mortgagee, (g) be responsible for any monies owing by Landlord to the credit of Tenant or (h) be required to remove any person occupying the Premises or any part
thereof; and such sublease shall provide that the subtenant thereunder shall, at the request of Landlord, execute a suitable instrument in confirmation of such agreement to attorn. The provisions of
this paragraph shall not be deemed a waiver of the provisions set forth in the first paragraph of this Subsection 6.2.1. 

        Tenant
shall not enter into, nor shall it permit any person having an interest in the possession, use, occupancy or utilization of any part of the Premises to enter into, any sublease,
license, concession, assignment or other agreement for use, occupancy or utilization of the Premises (i) which provides for rental or other compensation based on the income or profits derived
by any person or on any other formula such that any portion of such sublease rental, or other consideration for a license, concession, assignment or other occupancy agreement, would fail to qualify as
"rents from real property" within the meaning of Section 856(d) of the Internal Revenue Code or any similar or successor provision thereto, or would otherwise disqualify Landlord for treatment
as a real estate investment trust under Sections 856-869 of the Internal Revenue Code, (ii) under which fifty percent (50%) or more of the total rent or other compensation received
by Tenant is attributable to personal property or (iii) which would otherwise be subject to the prohibitions of Section 406 of ERISA or result in imposition of any tax pursuant to
Section 511 or Section 4975 of the Internal Revenue Code; and any such purported lease, sublease, license, concession or other agreement shall be absolutely void and ineffectual as a
conveyance of any right or interest in the possession, use, occupancy or utilization of such part of the Premises. 

23

 

        No
subletting or assignment shall in any way impair the continuing primary liability of Tenant hereunder, and no consent to any subletting or assignment in a particular instance shall be
deemed to be a waiver of the obligation to obtain the Landlord's written approval in the case of any other subletting or assignment. The joint and several liability of Tenant named herein and any
immediate and remote successor in interest of Tenant (by assignment or otherwise), and the due performance of the obligations of this Lease on Tenant's part to be performed or observed, shall not in
any way be discharged, released or impaired by any (a) agreement which modifies any of the rights or obligations of the parties under this Lease, (b) stipulation which extends the time
within which an obligation under this Lease is to be performed, (c) waiver of the performance of an obligation required under this Lease, or (d) failure to enforce any of the obligations
set forth in this Lease. No assignment, subletting or occupancy shall affect the Permitted Uses. Any subletting, assignment or other transfer of Tenant's interest in this Lease in contravention of
this Subsection 6.2.1 shall be voidable at Landlord's option. Tenant shall not occupy any space in the Building (by assignment, sublease or otherwise) other than the Premises. 

        If
the rent and other sums (including, without limitation, all monetary payments plus the reasonable value of any services performed or any other thing of value given by any assignee or
subtenant in consideration of such assignment or sublease), either initially or over the term of any assignment or sublease (other than a Permitted Assignment of a Permitted Sublease), payable by such
assignee or subtenant exceed the Annual Fixed Rent plus Additional Rent called for hereunder with respect to the space assigned or sublet, Tenant shall pay seventy-five percent (75%) of
such excess to Landlord, as Additional Rent, payable monthly at the time for payment of Annual Fixed Rent. Nothing in this paragraph shall be deemed to abrogate the provisions of this Subsection 6.2.1
and Landlord's acceptance of any sums pursuant to this paragraph shall not be deemed a granting of consent to any assignment of the Lease or sublease of all or any portion of the Premises. 

        6.2.2    Nuisance.    Tenant shall not injure, deface or otherwise harm the Premises; nor commit any nuisance; nor
permit in the Premises any vending machine (except such as is used for the sale of merchandise to employees of Tenant) or inflammable fluids or chemicals (except such as are customarily used in
connection with standard office uses and biotechnology research and manufacturing); nor permit any cooking to such extent as requires special exhaust venting; nor permit the emission of any
objectionable noise or odor; nor make, allow or suffer any waste; nor make any use of the Premises which is improper, offensive or contrary to any law or ordinance or which will invalidate or increase
the premiums for any of Landlord's insurance or which is liable to render necessary any alteration or addition to the Building; nor conduct any auction, fire, "going out of business" or bankruptcy
sales. 

        6.2.3    Equipment.    Landlord reserves the right to reasonably prescribe the position of all heavy business machines
and equipment, including safes, so as to distribute the weight. Tenant shall not put a load upon any floor of the premises exceeding 450 pounds per square foot. Business machines and mechanical
equipment which cause vibration or noise outside of the Premises shall be placed and maintained by Tenant at Tenant's expense in settings sufficient to absorb and prevent such vibration, noise and
annoyance to other tenants of the Complex. Tenant shall not move any safe, heavy machinery, heavy equipment, freight, construction materials or fixtures into or out of the Premises without Landlord's
prior consent which consent may include a requirement to provide insurance naming Landlord, and the holder of any mortgage affecting the Complex, as additional insureds, with such coverage and in such
amount as Landlord reasonably requires. If any such safe, machinery, heavy equipment, freight, or fixtures requires special handling, Tenant agrees to employ only persons holding a master rigger's
license to do said work, and that all work in connection therewith shall comply with applicable laws and regulations. Any such moving shall be at the sole risk and hazard of Tenant and Tenant hereby
agrees to exonerate, 

24

 

indemnify
and save Landlord harmless against and from any liability, loss, injury, claim or suit resulting directly or indirectly from such moving. Tenant shall schedule such moving at such times as
Landlord shall reasonably designate. 

        6.2.4    Electricity.    Tenant shall not connect to the electrical distribution system serving the Premises a total
load exceeding the capacity of such system or the maximum load permitted from time to time under applicable governmental regulations. 

        6.2.5    Installations, Alterations or Additions.    Tenant shall make no installations, alterations or additions in,
to or on the Premises and shall not permit the making of any holes in the walls, partitions, ceilings or floors without on each occasion obtaining the prior consent of Landlord, and then only pursuant
to plans and specifications approved by Landlord in advance in each instance. Notwithstanding anything to the contrary in this Lease (including without limitation Exhibit C), Tenant may make
cosmetic changes to the Premises (e.g. changes to carpet and paint) and changes to Tenant's improvements within the Premises that do not affect the systems or structure of the Building and do not cost
more than $10,000.00 for any one job, upon not less than ten (10) days prior written notice to Landlord (which notice shall describe the work to be performed in reasonable detail) but without
Landlord's prior consent. With respect to alterations that require Landlord's prior consent, Landlord shall not unreasonably withhold, condition or delay such consent for alterations that comply with
the
requirements of Exhibit C, provided that Landlord may, without limitation, withhold its consent to any proposed alterations that (i) are inconsistent with premises devoted to first-class
office or biomedical research, development and manufacturing uses, (ii) alter the structural elements or exterior of the Building, (iii) will cause any Operating Cost to materially
exceed what is normal for similar premises used for similar uses in the Complex, or (iv) will adversely affect the value or marketability of the Building, as reasonably determined by Landlord.
All work to be performed to the Premises by Tenant (a) shall be performed in a good and workmanlike manner by contractors approved in advance by Landlord and in compliance with the provisions
of Exhibit C and all applicable zoning, building, fire, health and other codes, regulations, ordinances and laws, (b) shall be made at Tenant's sole cost and expense and at such times
and in such a manner as Landlord may from time to time designate, and (c) shall become part of the Premises and the property of Landlord without being deemed Additional Rent for tax purposes,
Landlord and Tenant agreeing that Tenant shall be treated as the owner for tax purposes until the expiration or earlier termination of the term hereof, subject to Landlord's rights pursuant to
Subsection 6.1.9 to require Tenant to remove the same at or prior to the expiration or earlier termination of the term hereof. Tenant shall pay promptly when due the entire cost of any work to the
Premises so that the Premises, Building and Complex shall at all times be free of liens for labor and materials, and, at Landlord's request, Tenant shall furnish to Landlord a bond or other security
acceptable to Landlord assuring that any such work will be completed in accordance with the plans and specifications theretofore approved by Landlord and assuring that the Premises will remain free of
any mechanics' lien or other encumbrances that may arise out of such work. Prior to the commencement of any such work, and throughout and until completion thereof, Tenant shall maintain, or cause to
be maintained, the insurance required by Exhibit D, all with coverage limits as stated therein or such higher limits as shall be reasonably required by Landlord. In addition, Tenant shall save
Landlord harmless and indemnified from all injury, loss, claims or damage to any person or property occasioned by or arising out of such work. Whenever and as often as any mechanic's or materialmen's
lien shall have been filed against the Building or the Complex based upon any act of Tenant or of anyone claiming through Tenant, Tenant shall within three (3) days of notice from Landlord to
Tenant take such action by bonding, deposit or payment as will remove or satisfy the lien. 

        Landlord
or its representatives shall have the right to post, and keep posted upon the Premises, notices of non-responsibility or such other notices which Landlord may deem
to be 

25

 

proper
for the protection of Landlord's interest in the Premises and the Building. Tenant, before the commencement of any work from which a mechanic's or materialmen's lien may arise, shall give to
Landlord written notice of Tenant's intention to commence such work in sufficient time to enable Landlord to post such notices. 

        Tenant
shall not, at any time, directly or indirectly, employ or permit the employment of any contractor, mechanic or laborer in the Premises, if such employment will interfere or cause
any conflict with other contractors, mechanics or laborers engaged in the construction, maintenance or operation of the Building by Landlord, Tenant or others. In the event of any such interference or
conflict, Tenant, upon demand of Landlord, shall cause all contractors, mechanics or laborers causing such interference or conflict to leave the Building immediately. 

        6.2.6    Signs.    Tenant shall not paint or place any signs or place any awnings, aerials, or the like, visible from
outside the Premises. Landlord will not unreasonably withhold consent for signs or lettering on the entry doors to the Premises provided such signs conform to building standards adopted by Landlord
and Tenant has submitted to Landlord a plan or sketch of the sign to be placed on such entry doors. Tenant may also install Except for an entry-door sign approved by Landlord, Tenant shall
not install any signs on the exterior of the Building. 

        So
long as (i) there then exists no Default of Tenant, (ii) the Tenant named in Section 1.1 of this Lease (or any successor by merger) and/or any Affiliate shall
occupy not less than eighty percent (80%) of the Premises, and (iii) this Lease is still in full force and effect, then Tenant shall have the right, at its sole cost and expense, to install and
maintain on each of the monument signs dedicated to the Building a sign identifying Tenant, which shall conform to the CC&R's and all applicable laws and codes, and shall be subject to Landlord's
prior approval, not to be unreasonably withheld, conditioned or delayed. Notwithstanding any provision of this Lease to the contrary, any such monument signage shall be maintained in good repair and
condition by Tenant at its sole cost and expense, and Tenant and shall remove such signage upon the expiration or earlier termination of the Lease. Tenant's rights hereunder to install and maintain
monument signage are personal to Tenant and shall not be assignable to any assignee, subtenant or other party except in connection with an assignment of this Lease to a successor to Tenant by merger
or acquisition, or a sublease to an Affiliate who shall occupy at least eighty percent (80%) of the Premises. 

        6.2.7    Abandonment.    Tenant shall not abandon or vacate the Premises during the term. 

        6.2.8    Hazardous Materials.    Tenant shall not (a) introduce on or transfer to or store on the Premises, the
Building or the Complex or use on the Premises, any Hazardous Materials (as hereinafter defined), except such Hazardous Materials in such amounts as are reasonably necessary for the conduct of the
Permitted Uses, and then only in compliance with all Environmental and Health Laws (as hereinafter defined) and the terms and conditions of recommendations, policies or requirements of any insurer of
the Building or Complex ("Insurance Conditions"); (b) dump, flush or otherwise dispose of any Hazardous Materials into the drainage, sewage or
waste disposal systems serving the Premises, the Building or the Complex; (c) generate, release, spill or dispose of any Hazardous Materials in or on the Premises, the Building or the Complex,
or (d) transfer any Hazardous Materials from the Premises to any other location (except the transfer of such Hazardous Materials expressly permitted to be used on the Premises from the Premises
for disposal and then only in compliance with all Environmental and Health Laws and Insurance Conditions); and shall not commit or suffer to be committed in or on the Premises, the Building or the
Complex any act which would require any reporting or filing of any notice with any governmental agency pursuant to any Environmental and Health Laws except in connection with the Permitted Uses. 

26

 

        Tenant
agrees that if it or anyone claiming under it shall transfer to the Premises, store, use or dispose (except to the extent expressly permitted above), generate, release, threaten
release or spill, any
Hazardous Materials, it shall forthwith remove the same, at its sole cost and expense, in the manner provided by all applicable Environmental and Health Laws, regardless of when such Hazardous
Materials shall be discovered. Furthermore, Tenant shall pay any fines, penalties or other assessments imposed by any governmental agency with respect to any such Hazardous Materials and shall
forthwith repair and restore any portion of the Premises, the Building or the Complex which it shall disturb in so removing any such Hazardous Materials to the condition which existed prior to
Tenant's disturbance thereof. 

        Tenant
agrees to deliver promptly to Landlord any notices, orders or similar documents received from any governmental agency or official concerning any violation of any Environmental and
Health Laws or with respect to any Hazardous Materials affecting the Premises, the Building or the Complex. In addition, Tenant shall, within ten (10) days of receipt, accurately complete any
questionnaires from Landlord or other informational requests relating to Tenant's use of the Premises and, in particular, to Tenant's use, generation, storage and/or disposal of Hazardous Materials
at, to, or from the Premises. 

        Tenant
shall indemnify, defend (by counsel satisfactory to Landlord), protect, and hold Landlord free and harmless from and against any and all claims, or threatened claims, including
without limitation, claims for death of or injury to any person or damage to any property, actions, administrative proceedings, whether formal or informal, judgments, damages, punitive damages,
liabilities, penalties, fines, costs, taxes, assessments, forfeitures, losses, expenses, attorneys' fees and expenses, consultant fees, and expert fees that arise from or are caused in whole or in
party, directly or indirectly, by (i) Tenant's use, analysis, storage, transportation, disposal, release, threatened release, discharge or generation of Hazardous Materials to, in, on, under,
about or from the Premises, or (ii) Tenant's failure to comply with any Environmental and Health Laws. Tenant's obligations hereunder shall include, without limitation, and whether foreseeable
or unforeseeable, all costs (including, without limitation, capital, operating and maintenance costs) incurred in connection with any investigation or monitoring of site conditions, repair, cleanup,
containment, remedial, removal or restoration work, or detoxification or decontamination of the Premises, and the preparation and implementation of any closure, remedial action or other required plans
in connection therewith. For purposes of this Subsection 6.2.8, any acts or omissions of Tenant, or its subtenants or assignees or its or their employees, agents, or contractors (whether or not they
are negligent, intentional, willful or unlawful) shall be attributable to Tenant. 

        The
term "Hazardous Materials" shall mean and include any Excepted Waste, asbestos and asbestos-containing materials, air pollutants or
contaminants, crude and refined oil and the products and by-products of oil and petroleum, radioactive, biological, medical or infectious wastes or materials, and any other toxic or
hazardous wastes, materials and substances which are defined, determined or identified as a hazardous substance or hazardous waste, extremely hazardous waste, infectious waste, non-RCRA
waste, retrograde material, restricted hazardous waste, volatile organic compound, waste or similarly defined, determined or identified in any Environmental and Health Laws, or in any judicial or
administrative interpretation of Environmental and Health Laws. 

        The
term "Environmental and Health Laws" shall mean any and all present and future federal, state, county and municipal or other local
statutes, laws, regulations, ordinances, rules, judgments, orders, decrees, codes, plans, injunctions, permits, concessions, grants, franchises, licenses, agreements or other governmental restrictions
applicable to the Complex relating to Hazardous Materials or the environment or to emissions, discharges or releases or threatened releases of Hazardous Materials into the environment, including,
without limitation, into the ambient air, surface water, ground water or in, on or under any land, or otherwise relating to the manufacture, processing, distribution, use, treatment, storage, release
or threatened release, disposal, transport 

27

 

or
handling of Hazardous Materials or the cleanup or other remediation thereof. Environmental and Health Laws include, without limitation, the following: the Comprehensive Environmental Response,
Compensation and Liability At of 1980, as amended (42 U.S.C. §9601 et. seq.), the Hazardous Materials Transportation Act, as amended (49
U.S.C. §1801 et seq.), the Resource Conservation and Recovery Act of 1976, as amended (42 U.S.C. §6901  et seq.), the California Safe Drinking
Water and Toxic Enforcement Act of 1986 (Health and Safety Code §25249.5 et
seq.), the California Hazardous Waste Control Act (Health and Safety Code §25100 et seq.) 

        The
obligations of Tenant contained in this Subsection 6.2.8 shall survive the expiration or termination of this Lease. 

        Landlord
represents that to the best of Landlord's knowledge there are no Hazardous Materials in the Premises except as disclosed in Environmental Site Assessment for the Sorrento Valley
Business Park, 5555, 5601, 5626 and 5627 Oberlin Drive, San Diego California, prepared by Act Environmental, Inc., dated December 30, 1996, and the Phase I Environmental Site Assessment
of 5555 Oberlin Drive, San Diego, CA, prepared by Occupational Services, Inc., dated November 26, 2002 (collectively, the "Environmental
Report"), copies of which has been provided to Tenant. Landlord agrees that so long as the condition requiring removal or remediation of Hazardous Materials is not caused by
Tenant or any party for whom Tenant is responsible, Landlord shall, in a manner that complies with all applicable Environmental and Health Laws, perform or cause others to perform all remediation and
cleanup of the Common Areas of the Complex necessary to cause the same to comply in all material respects with Environmental and Health Laws, to the extent the failure to do so shall materially
adversely affect Tenant or expose it to material liability. If Tenant shall become aware of any condition which Tenant alleges shall obligate Landlord to perform remediation it shall give Landlord
notice of such condition ("Tenants' Notice") which shall expressly state that failure to perform remediation timely shall afford Tenant the right to
terminate the term of this Lease. Landlord and Tenant agree that in the event of any dispute between them concerning the obligation of Landlord to perform the remediation or cleanup of any Hazardous
Materials pursuant to this paragraph is not resolved within ten (10) days of receipt of Tenant's Notice, either party may submit the dispute to the American Arbitration Association for
resolution by arbitration in accordance with the commercial arbitration rules of the American Arbitration Association. The decision of the arbitrator, who shall be an independent California Registered
Environmental Assessor with experience dealing with the type of Hazardous Materials at issue in similar properties in the San Diego area, shall be made within thirty (30) days of submission and
shall be final and binding on Landlord and Tenant and judgment thereon may be entered in any court of competent jurisdiction. 

        In
the event (i) the time required for Landlord to complete any remediation which Landlord is obligated to perform pursuant to the preceding paragraph shall exceed the lesser of
nine (9) months or one-half of the remainder of the term hereof measured from the date of Tenant's Notice (whichever is less being the "Completion
Period"), or (ii) Landlord shall not complete any remediation it is required to perform within the Completion Period, then Tenant shall have the right, as its sole
remedy, to terminate the term of this Lease by giving notice of its desire to do so to Landlord within ten (10) days after the earlier of the agreement by the parties or the determination of
the arbitrator as to such obligation of Landlord in the first case, and in the second case, the expiration of such Completion Period, whereupon on the date thirty (30) days after the giving of
such notice, the term of this Lease shall terminate with the same force and effect as if such date were the date on which the term of this Lease were scheduled to expire. The nine-month
remediation period described clauses (i) and (ii) of the preceding sentence shall be reduced to six (6) months in the case of any condition requiring remediation by Landlord
discovered during the last three (3) years of the term. 

28

 

Article 7
 Casualty or Taking  

        7.1    Termination.    In the event that the Premises, the Building or the Complex, or any material part thereof shall
be destroyed or damaged by fire or casualty to such an extent that the time reasonably necessary for Landlord to make repairs as required by Section 7.2 in the ordinary course, as reasonably
estimated by Landlord, shall exceed either nine (9) months or one-half of the remainder of the term hereof (whichever is less) from the date of fire or other casualty, or the
Premises, the Building or the Complex, or any material part thereof shall be taken by any public authority or for any public use or shall be condemned by the action of any public authority, then this
Lease may be terminated at the election of Landlord. Such election, which may be made notwithstanding the fact that Landlord's entire interest may have been divested, shall be made by the giving of
notice by Landlord to Tenant within sixty (60) days after the date of the taking or casualty. 

        In
the event that (i) at least twenty-five percent (25%) of the Premises is damaged by fire or other casualty to such an extent that the time reasonably necessary for
Landlord to make repairs as required by Section 7.2 in the ordinary course shall exceed either nine (9) months or one-half of the remainder of the term hereof (whichever is
less) from the date of fire or other casualty, or (ii) at least twenty-five percent (25%) of the Premises is damaged by fire or other casualty and repairs are not actually
substantially completed within nine (9) months from the date of the fire or other casualty, or (iii) any material portion of the Premises is taken by an exercise of eminent domain, then
in any such case Tenant shall have the right to terminate the term of this Lease by giving notice of its desire to do so to Landlord within sixty (60) days after, in the first or
third case, such damage or taking, and in the second case, the expiration of such nine-month period, whereupon on the date thirty (30) days after the giving of such notice, the term
of this Lease shall terminate with the same force and effect as if such date were the date on which the term of this Lease were scheduled to expire. The nine-month repair periods described
in clauses (i) and (ii) of the preceding sentence shall be reduced to six (6) months in the case of a casualty occurring during the last three (3) years of the term.
Notwithstanding the foregoing to the contrary, Tenant shall have no right to terminate the term of this Lease due to a fire or other casualty if the cause thereof was due to the negligence or other
wrongful conduct of Tenant or any subtenant of Tenant or any agent, employee or invitee of Tenant or its subtenant(s). 

        7.2    Restoration.    If neither Landlord nor Tenant elects to so terminate, this Lease shall continue in force and
(so long as the damage is not caused by the negligence or other wrongful act of Tenant or its employees, agents, contractors or invitees) a just proportion of the Annual Fixed Rent reserved, according
to the nature and extent of the damages sustained by the Premises, shall be suspended or abated until the Premises (excluding any improvements to the Premises made at Tenant's expense), or what may
remain thereof, shall be put by Landlord in proper condition for use, which Landlord covenants to do with reasonable diligence to the extent permitted by the net proceeds of insurance recovered or
damages awarded for such destruction, taking, or condemnation and subject to zoning and building laws or ordinances then in existence. "Net proceeds of insurance recovered or
damages awarded" refers to the gross amount of such insurance or damages actually made available to Landlord (and not retained by any Superior Lessor or Superior Mortgagee)
less the reasonable expenses of Landlord incurred in connection with the collection of the same, including without limitation, fees and expenses for legal and appraisal services. 

        7.3    Award.    Irrespective of the form in which recovery may be had by law, all rights to damages or compensation
shall belong to Landlord in all cases. Tenant hereby grants to Landlord all of Tenant's rights to such damages and covenants to deliver such further assignments thereof as Landlord may from time to
time request. Nothing contained herein shall be construed to prevent Tenant from prosecuting in any condemnation proceedings a claim for relocation expenses, provided that such action 

29

 

shall
not affect the amount of compensation otherwise recoverable by Landlord from the taking authority. 

        7.4    Termination Waiver.    Tenant waives the provisions of California Civil Code Sections 1932(2) and 1933(4) (and
all similar or successor statutes) which relate to the termination of leases when the thing leased is destroyed, and agrees that such event shall be governed by the terms of this Lease. 

Article 8
 Defaults  

        8.1    Default of Tenant.    The occurrence of any one or more of the following shall constitute a
"Default of Tenant" under this Lease: 

        (a)   The
failure by Tenant to make any payment of Annual Fixed Rent, Additional Rent or any other payment required to be made by Tenant hereunder (collectively,
"Rent"), as and when due, where such failure shall continue for ten (10) days after notice thereof from
Landlord to Tenant; provided, however, that any such notice shall be in lieu of, and not in addition to, any notice required under California Code of Civil Procedure §1161. 

        (b)   The
failure by Tenant to observe or perform any of the express or implied covenants or provisions of this Lease to be observed and performed by Tenant, other than as
specified in subsection (a) above, where such failure shall continue for a period of thirty (30) days after written notice thereof from Landlord to Tenant; provided, however, that any
such notice shall be in lieu of, and not in addition to, any notice required under California Code of Civil Procedure §1161; provided, further, that if the nature of Tenant's default is
such that more than thirty (30) days are reasonably required for its cure, then Tenant shall not be deemed to be in default if Tenant shall commence such cure within such thirty (30) day
period and thereafter diligently prosecute such cure to completion within sixty (60) days from the date of such notice from Landlord. 

        (c)   An
assignment by Tenant or any guarantor of Tenant for the benefit of creditors. 

        (d)   The
taking by execution or levy of Tenant's leasehold interest. 

        (e)   The
filing of a lien or other involuntary encumbrance against Tenant's leasehold interest or Tenant's other property, including said leasehold interest, or against the
property of any guarantor of Tenant, which filing shall not be discharged within ten (10) days after Tenant receives notice thereof. 

        (f)    The
filing of a petition by Tenant or any guarantor of Tenant for liquidation, or for reorganization or an arrangement under any provision of any bankruptcy law or code
as then in force and effect. 

        (g)   The
filing of an involuntary petition under any of the provisions of any bankruptcy law or code against Tenant or any guarantor of Tenant and such involuntary petition
shall not be dismissed within thirty (30) days thereafter. 

        (h)   The
appointment of a custodian, receiver or similar agent shall be authorized or appointed to take charge of all or substantially all of the assets of Tenant or any
guarantor of Tenant. 

        (i)    The
dissolution or liquidation of Tenant or any guarantor of Tenant or the adoption of any plan or the commencement of any proceeding, the result of which is or is
intended to include the dissolution or liquidation of Tenant or any guarantor of Tenant. 

        (j)    The
entry of an order in any proceeding by or against Tenant or any guarantor of Tenant decreeing or permitting the dissolution of Tenant or any guarantor of Tenant or
the winding up of its affairs. 

30

   
        8.2    Remedies.    In the event of a Default of Tenant, in addition to all other rights or remedies Landlord may
have, Landlord, acting through its employees, agents or servants, may terminate this Lease by notice to Tenant in the manner provided in Section 10.1. In addition to all other rights or
remedies Landlord may have, in the event of a Default of Tenant, Landlord shall have the immediate right to re-enter and repossess the Premises. Should Landlord elect to
re-enter as herein provided, or should Landlord take possession pursuant to legal proceedings or pursuant to any notice provided by law, and should Landlord elect to terminate this Lease,
Landlord may recover from Tenant: 

        (1)   The
worth at the time of the award of the unpaid Rent which is due, owing and unpaid by Tenant to Landlord at the time of termination; and 

        (2)   The
worth at the time of the award of the amount by which the unpaid Rent which would have been earned after termination until the time of the award exceeds the amount
of the rent loss Tenant proves could have been reasonably avoided; and 

        (3)   The
worth at the time of the award of the amount by which the unpaid Rent for the balance of the Term after the time of award exceeds the amount of rental loss which
Tenant proves could be reasonably avoided; and 

        (4)   All
other amounts necessary to compensate Landlord for all the detriment proximately caused by Tenant's failure to perform its obligations under this Lease or which in
the ordinary course of events are likely to result therefrom including all costs (including attorneys' fees) of recovering possession of the Premises, removing persons or property from the Premises,
repairs, brokers' fees, advertising and alterations to the Premises in connection with reletting the Premises; and 

        (5)   At
Landlord's election, other amounts in addition to or in lieu of the above as may be permitted from time to time by applicable law. 

        All
computations of the worth at the time of amounts recoverable by Landlord under clauses (1), (2) and (4) above shall be computed by allowing interest at the Default Rate
(as defined in Section 8.4). The worth at the time of award recoverable by Landlord under clause (3) above shall be computed by discounting the amount otherwise recoverable by Landlord
at the discount rate of the Federal Reserve Bank of San Francisco plus one percent (1%). 

        If
the Premises or any part of the Premises are vacated or abandoned, or if Landlord takes possession of the Premises pursuant to legal proceedings or pursuant to any notice provided by
applicable law, and if Landlord does not elect to terminate this Lease, Landlord may from time to time, without terminating this Lease, recover all Rent as it becomes due and, at Landlord's election,
relet the Premises or any part of the Premises upon such terms, at such rent, upon such conditions and for such a period of time as Landlord in its sole discretion may deem advisable. Landlord shall
also have the right to make such alterations, repairs and decorations in the Premises as Landlord in its sole judgment considers advisable and necessary for the purpose of reletting the Premises; and
the making of such alterations, repairs and decorations shall not operate or be construed to release Tenant from liability hereunder as aforesaid. Landlord shall apply to any unpaid amounts due
Landlord hereunder the net proceeds, if any, of any reletting of the Premises, after deducting all expenses in connection therewith, including, without limitation, all repossession costs, brokerage
commissions, legal expenses, attorneys' fees, advertising, expenses of employees, alteration costs and expenses of preparing the Premises for such reletting. Tenant hereby waives all right to receive
all or any portion of the net proceeds of any such reletting. Landlord shall in no event be liable for failure to relet the Premises, or, in the event that the Premises are relet, for failure to
collect the rent under such reletting. 

        In
the event that Tenant should breach this Lease, Landlord may, at it option, enforce all of its rights and remedies under this Lease, including the right to recover the Rent as it
becomes due hereunder. Additionally, Landlord shall be entitled to recover from Tenant all costs of maintenance and 

31

 

preservation
of the Premises, and all costs, including attorneys' fees, to protect the Premises and Landlord's interest under this Lease. 

        At
any time after a Default of Tenant occurs, Landlord may re-enter the Premises and remove all persons and property from the Premises; such property may be removed and
stored in a public warehouse or elsewhere at the cost of and for the account of Tenant. No re-entry into the Premises by Landlord pursuant to this paragraph shall be construed as an
election to terminate this Lease unless a written notice of such intention is given to Tenant. 

        To
the fullest extent permitted by law, Tenant hereby waives all rights of redemption or relief from forfeiture under California Civil Procedure Sections 1174 and 1179, or under any
other present or future law, in the event Tenant is evicted or Landlord takes possession of the Premises by reason of any Default of Tenant. 

        8.3    Remedies Cumulative.    Any and all rights and remedies which Landlord may have under this Lease, and at law
and equity for Tenant's failure to comply with its obligations under this Lease shall be cumulative and shall not be deemed inconsistent with each other, and any two or more of all such rights and
remedies may be exercised at the same time insofar as permitted by law. Notwithstanding
any provision of this Lease to the contrary, in no event shall Tenant be liable for any loss of business, or any other indirect, special or consequential damages, except as provided in
Section 8.5. 

        8.4    Landlord's Right to Cure Defaults.    At any time with or without notice, Landlord shall have the right, but
shall not be required, to pay such sums or do any act which requires the expenditure of monies which may be necessary or appropriate by reason of the failure or neglect of Tenant to comply with any of
its obligations under this Lease (irrespective of whether the same shall have ripened into a Default of Tenant), and in the event of the exercise of such right by Landlord, Tenant agrees to pay to
Landlord forthwith upon demand, as Additional Rent, all such sums including reasonable attorneys fees, together with interest thereon at a rate (the "Default
Rate") equal to the greater of six percent (6%) over the Prime Rate or twelve percent (12%) per annum, but in no event in excess of the maximum rate of interest then permitted
to be agreed to by the parties under applicable law. "Prime Rate" shall mean the annual floating rate of interest, determined daily and expressed as a
percentage from time to time announced by the largest national or state-chartered banking institution in the state or district in which the Complex is located as its "prime" or "base" rate. If, at any
time, both the largest national and state-chartered banking institutions having their principal offices in the City of San Diego, shall cease to announce such a floating rate, Prime Rate shall mean a
rate of interest, determined daily, which is two (2) percentage points above the 14-day moving average closing trading price of 90-day Treasury Bills. 

        8.5    Holding Over.    Any holding over by Tenant after the expiration or early termination of the term of this Lease
shall be treated as a daily tenancy at sufferance at a rate equal to one hundred and fifty percent (150%) of the greater of the fair market rental value for the Premises on a
month-to-month basis or the Annual Fixed Rent in effect immediately prior to the expiration or earlier termination of the term plus Additional Rent and other charges herein
provided (prorated on a daily basis). Tenant shall also pay to Landlord all damages, direct and/or consequential (foreseeable and unforeseeable), sustained by reason of any such holding over.
Otherwise, all of the covenants, agreements and obligations of Tenant applicable during the term of this Lease shall apply and be performed by Tenant during such period of holding over as if such
period were part of the term of this Lease. 

        8.6    Effect of Waivers of Default.    Any consent or permission by Landlord to any act or omission by Tenant shall
not be deemed to be consent or permission by Landlord to any other similar or dissimilar act or omission and any such consent or permission in one instance shall not be deemed to be consent or
permission in any other instance. 

32

 

        8.7    No Waiver, etc.    The failure of Landlord or Tenant to seek redress for violation of, or to insist upon the
strict performance of, any covenant or condition of this Lease shall not be deemed a waiver of such violation nor prevent a subsequent act, which would have originally constituted a violation, from
having all the force and effect of an original violation. The receipt by Landlord of rent with knowledge of the breach of any covenant of this Lease shall not be deemed to have been a waiver of such
breach by
Landlord, or by Tenant, unless such waiver be in writing signed by the party to be charged. No consent or waiver, express or implied, by Landlord or Tenant to or of any breach of any agreement or duty
shall be construed as a waiver or consent to or of any other breach of the same or any other agreement or duty. 

        8.8    No Accord and Satisfaction.    No acceptance by Landlord of a lesser sum than the Annual Fixed Rent, Additional
Rent or any other charge then due shall be deemed to be other than on account of the earliest installment of such rent or charge due, nor shall any endorsement or statement on any check or any letter
accompanying any check or payment as rent or other charge be deemed an accord and satisfaction, and Landlord may accept such check or payment without prejudice to Landlord's right to recover the
balance of such installment or pursue any other remedy in this Lease provided. 

Article 9 

Rights of Holders  

        9.1    Rights of Mortgagees or Ground Lessors.    This Lease, and all rights of Tenant hereunder, are and shall be
subject and subordinate to any ground or master lease, and all renewals, extensions, modifications and replacements thereof, and to all mortgages, which may now or hereafter affect the Building or the
Complex and/or any such lease, whether or not such mortgages shall also cover other lands and/or buildings and/or leases, to each and every advance made or hereafter to be made under such mortgages,
and to all renewals, modifications, replacements and extensions of such leases and such mortgages and all consolidations of such mortgages. This Section shall be self-operative and no
further instrument of subordination shall be required. In confirmation of such subordination, Tenant shall promptly execute, acknowledge and deliver any instrument that Landlord, the lessor under any
such lease or the holder of any such mortgage or any of their respective successors in interest may reasonably request to evidence such subordination. Any lease to which this Lease is subject and
subordinate is herein called "Superior Lease" and the lessor of a Superior Lease or its successor in interest, at the time referred to, is herein called
"Superior Lessor"; and any mortgage to which this Lease is subject and subordinate, is herein called "Superior
Mortgage" and the holder of a Superior Mortgage is herein called "Superior Mortgagee". Landlord represents that the Complex is
not subject to any Superior Lease as of the Date of this Lease. 

        If
any Superior Lessor or Superior Mortgagee or the nominee or designee of any Superior Lessor or Superior Mortgagee shall succeed to the rights of Landlord under this Lease, whether
through possession or foreclosure action or delivery of a new lease or deed, or otherwise, then at the request of such party so succeeding to Landlord's rights (herein called
"Successor Landlord") and upon such Successor Landlord's written agreement to accept Tenant's attornment, Tenant shall attorn to and recognize such
Successor Landlord as Tenant's landlord under this Lease and shall promptly execute and deliver any instrument that such Successor Landlord may reasonably request to evidence such attornment. Upon
such attornment, this Lease shall continue in full force and effect as a direct lease between the Successor Landlord and Tenant upon all of the terms, conditions and covenants as are set forth in this
Lease, except that the Successor Landlord (unless formerly the landlord under this Lease) shall not be (a) liable in any way to Tenant for any act or omission, neglect or default on the part of
Landlord under this Lease, (b) responsible for any monies owing by or on deposit with Landlord to the credit of Tenant, (c) subject to any counterclaim or setoff which theretofore
accrued to Tenant against Landlord, (d) bound by any modification of this Lease subsequent to such Superior Lease or Superior 

33

 

Mortgage,
or by any previous prepayment of Annual Fixed Rent or Additional Rent for more than one (1) month, which was not approved in writing by the Successor Landlord, (e) liable to
the Tenant beyond the Successor Landlord's interest in the Building, (f) responsible for the performance of any work to be done by Landlord under this Lease to render the Premises ready for
occupancy by the Tenant, or (g) required to remove any person occupying the Premises or any part thereof, except if such person claims by, through or under the Successor Landlord. Tenant agrees
at any time and from time to time to execute a suitable instrument in confirmation of Tenant's agreement to attorn, as aforesaid. 

        9.2    Modifications.    If any Superior Lessor or Superior Mortgagee shall require any modification(s) of this Lease,
Tenant shall, at Landlord's request, promptly execute and deliver to Landlord such instruments effecting such modification(s) as Landlord shall require, provided that such modification(s) do not
adversely affect in any material respect any of Tenant's rights under this Lease. In addition, and notwithstanding Section 9.1 to the contrary, any Superior Lessor or Superior Mortgagee may, at
its option, subordinate the Superior Lease or Superior Mortgage of which it is the lessor or holder to this Lease by giving Tenant ten (10) days prior written notice of such election, whereupon
this Lease shall, irrespective of dates of execution, delivery and recording, be superior to such Superior Lease or Superior Mortgage and no other documentation shall be necessary to effect such
change. 

        9.3    Non-Disturbance.    Landlord represents that the Lease is not subject to any Superior Mortgage or
Superior Lease as of the Date of this Lease. Landlord shall use diligent efforts (without the obligation to incur expense or liability in connection with such efforts) to obtain a
so-called non-disturbance agreement from any future Superior Lessor or Superior Mortgagee which agreement may be in the form customarily used by such Superior Lessor or
Superior Mortgagee, or if no such form exists, in any commercially reasonable form, subject to the conditions and limitations of Sections 9.1 and 9.2, provided, however, that if, despite such
reasonable efforts, Landlord is unable to obtain such agreement, such failure shall not constitute a default by Landlord under this Lease. 

Article 10 

Miscellaneous Provisions  

        10.1    Notices.    Except as may be expressly provided herein otherwise, all notices, requests, demands, consents,
approval or other communications to or upon the respective parties hereto shall be in writing, shall be delivered by hand or mailed by certified or registered mail, return receipt requested, or by a
nationally recognized courier service that provides a receipt for delivery such as Federal Express, United Parcel Service or U.S. Postal Service Express Mail and shall be addressed as follows: If
intended for Landlord, to the Original Address of Landlord set forth in Section 1.1 of this Lease with a copy to REIT Management & Research LLC, 400 Centre Street, Newton, MA 02464,
Attn: Jennifer B. Clark (or to such other address or addresses as may from time to time hereafter be designated by Landlord by notice to Tenant); and if intended for Tenant, addressed to Tenant at the
Original Address of Tenant set forth in Section 1.1 of this Lease until the Commencement Date and thereafter to the Complex (or to such other address or addresses as may from time to time
hereafter be designated by Tenant by notice to Landlord). Notices shall be effective on the date delivered to (or the first date such delivery is attempted and refused by) the party to which such
notice is required or permitted to be given or made under this Lease. Notices from Landlord may be given by Landlord's Agent, if any, or Landlord's attorney. 

        10.2    Quiet Enjoyment; Landlord's Right to Make Alterations, Etc.    Landlord agrees that, upon Tenant's paying the
rent and performing and observing the agreements, conditions and other provisions on its part to be performed and observed, Tenant shall and may peaceably and quietly have, hold and enjoy the Premises
during the term hereof without any manner of hindrance or molestation from 

34

 

Landlord
or anyone claiming under Landlord, subject, however, to the terms of this Lease; provided, however, Landlord reserves the right at any time and from time to time, without the same
constituting breach of Landlord's covenant of quiet enjoyment or an actual or constructive eviction, and without Landlord incurring any liability to Tenant or otherwise affecting Tenant's obligations
under this Lease, to make such changes, alterations, improvements, repairs or replacements in or to the interior and exterior of the Building (including the Premises) and the fixtures and equipment
thereof, and in or to the Building or the Complex, or properties adjacent thereto, as Landlord may deem necessary or desirable, and to change (provided that there be no unreasonable obstruction of the
right of access to the Premises by Tenant and that Landlord use commercially reasonable efforts to minimize, to the extent practical, any interference with the conduct of business at the Premises) the
arrangement and/or location of entrances or passageways, doors and doorways, corridors, elevators, or other common areas of the Building and the Complex. 

        Without
incurring any liability to Tenant, Landlord may permit access to the Premises and open the same, whether or not Tenant shall be present, upon any demand of any receiver, trustee,
assignee for the benefit of creditors, sheriff, marshal or court officer Landlord reasonably believes is entitled to such access for the purpose of taking possession of, or removing, Tenant's property
or for any other lawful purpose (but this provision and any action by Landlord hereunder shall not be deemed a recognition by Landlord that the person or official making such demand has any right or
interest in or to this Lease, or in or to the Premises), or upon demand of any representative of the fire, police, building, sanitation or other department of the city, state or federal governments. 

        10.3    Lease Not to be Recorded; Confidentiality of Lease Terms.    Tenant agrees that it will not record this Lease.
Both parties shall, upon the request of either, execute and deliver a notice or short form of this Lease in such form, if any, as may be acceptable for recording with the land records of the
governmental entity responsible for keeping such records. In no event shall such document set forth the rent or other charges payable by Tenant pursuant to this Lease; and any such document shall
expressly state that it is executed pursuant to the provisions contained in this Lease and is not intended to vary the terms and conditions of this Lease. 

        Tenant
acknowledges that the terms under which the Landlord has leased the Premises to Tenant (including, without limitation, the rental rate(s), term and other financial and business
terms), constitute confidential information of Landlord ("Confidential Information"). Tenant covenants and agrees to keep the Confidential Information
confidential and not to disclose the same to third parties; provided, however, that such Confidential Information may be disclosed by Tenant to those of its officers, employees, attorneys,
accountants, lenders, potential investors or acquirers of Tenant, and financial advisors (collectively, "Representatives") who need to know such
information in connection with Tenant's use and occupancy of the Premises and for financial reporting and credit related activities and to comply with laws, including securities laws and regulations.
Tenant furthermore agrees to inform its Representatives of the confidential nature of such Confidential Information and to use all reasonable efforts to cause each Representative to treat such
Confidential Information confidentially and in accordance with the terms of this paragraph. 

        10.4    Assignment of Rents and Transfer of Title; Limitation of Landlord's Liability.    With reference to any
assignment by Landlord of Landlord's interest in this Lease, or the rents payable hereunder, whether absolute or conditional in nature or otherwise, which assignment is made to the holder of a
mortgage on property which includes the Premises, Tenant agrees that the execution thereof by Landlord, and the acceptance thereof by the holder of such mortgage shall never be treated as an
assumption by such holder of any of the obligations of Landlord hereunder unless such holder shall, by notice sent to Tenant, specifically otherwise elect and that, except as aforesaid, such holder
shall be treated as having assumed Landlord's obligations hereunder (subject to the limitations set forth in Section 9.1) only upon foreclosure of such holder's mortgage and the taking of
possession of the Premises. 

35

 

        The
term "Landlord" as used in this Lease, so far as covenants or obligations to be performed by Landlord are concerned, shall be limited
to mean and include only the owner or owners at the time in question of Landlord's interest in the Complex, and in the event of any transfer or transfers of such title to said property, Landlord (and
in case of any subsequent transfers or conveyances, the then grantor) shall be concurrently freed and relieved from and after the date of such transfer or conveyance, without any further instrument or
agreement, of all liability with respect to the performance of any covenants or obligations on the part of Landlord contained in this Lease thereafter to be performed, it being intended hereby that
the covenants and obligations contained in this Lease on the part of Landlord, shall, subject as aforesaid, be binding on Landlord, its successors and assigns, only during and in respect of their
respective period of ownership of such interest in the Complex. Notwithstanding the foregoing, in no event shall the acquisition of Landlord's interest in the Building or the Complex by a purchaser
which, simultaneously therewith, leases Landlord's entire interest in the Building or the Complex back to Landlord or the seller thereof be treated as an assumption by operation of law or otherwise,
of Landlord's obligations hereunder. Tenant shall look solely to such seller-lessee, and its successors from time to time in title, for performance of Landlord's obligations hereunder. The
seller-lessee, and its successors in title, shall be the Landlord hereunder unless and until such purchaser expressly assumes in writing the Landlord's obligations hereunder. 

        Tenant
shall not assert nor seek to enforce any claim for breach of this Lease against any of Landlord's assets other than Landlord's interest in the Complex, and Tenant agrees to look
solely to such interest, including Landlord's interest in the rents therefrom, for the satisfaction of any liability or claim against Landlord under this Lease, it being specifically agreed that in no
event whatsoever shall Landlord ever be personally liable for any such liability. In addition, Landlord hereby notifies Tenant that the Declaration of Trust of Hub Properties Trust provides, and
Tenant agrees, that no trustee, officer, director, general or limited partner, member, shareholder, beneficiary, employee or agent of Landlord (including any person or entity from time to time engaged
to supervise and/or manage the operation of Landlord) shall be held to any liability, jointly or severally, for any debt, claim, demand, judgment, decree, liability or obligation of any kind (in tort,
contract or otherwise) of, against or with respect to Landlord or arising out of any action taken or omitted for or on behalf of Landlord. 

        10.5    Landlord's Default.    Landlord shall not be deemed to be in breach of, or in default in the performance of,
any of its obligations under this Lease unless it shall fail to perform such obligation(s) and such failure shall continue for a period of thirty (30) days, or such additional time as is
reasonably required to correct any such breach or default, after written notice has been given by Tenant to Landlord specifying the nature of Landlord's alleged breach or default. Tenant shall have no
right to terminate this Lease for any breach or default by Landlord hereunder and no right, for any such breach or default, to offset or counterclaim against any rent due hereunder. In no event shall
Landlord ever be liable to Tenant for any punitive damages or for any loss of business or any other indirect, special or consequential damages suffered by Tenant from whatever cause. Tenant further
agrees that if Landlord shall have failed to cure any such breach or default within thirty (30) days of such notice to Landlord (or if such breach or default cannot be cured within said time,
then within such additional time as may be necessary if within said thirty days Landlord has commenced and is diligently pursuing the remedies necessary to cure such breach or default), then the
holder(s) of any mortgage(s) or the lessor under any ground lease entitled to notice pursuant to Section 10.6 shall have an additional thirty (30) days within which to cure such breach
or default if such breach or default cannot be cured within that time, then such additional time as may be necessary, if within such thirty (30) days any such holder or lessor has commenced and
is diligently pursuing the remedies necessary to cure such breach or default (including but not limited to commencement of foreclosure proceedings, if necessary to effect such cure). 

        10.6    Notice to Mortgagee and Ground Lessor.    After receiving notice from any person, firm or other entity that it
holds a mortgage which includes the Premises as part of the mortgaged premises, or 

36

 

that
it is the ground lessor under a lease with Landlord, as ground lessee, which includes the Premises as part of the demised premises, no notice from Tenant to Landlord shall be effective unless and
until a copy of the same is given to such holder or ground lessor, and the curing of any of Landlord's defaults by such holder or ground lessor shall be treated as performance by Landlord. 

        10.7    Building or Complex Name Change.    Landlord shall have the right to change the name of the Building or the
Complex at any time and Tenant expressly waives any and all claims for damages against Landlord resulting therefrom. 

        10.8    Waiver of Jury Trial.    Landlord and Tenant hereby waive their respective right to trial by jury of any cause
of action, claim, counterclaim or cross-complaint in any action, proceeding and/or hearing brought by either Landlord against Tenant or Tenant against Landlord on any matter whatsoever arising out of,
or in any way connected with, this Lease, the relationship of Landlord and Tenant, Tenant's use or occupancy of the Premises, or any claim of injury or damage, or the enforcement of any remedy under
any law, statute or regulation, emergency or otherwise, now or hereafter in effect. 

        10.9    Brokerage.    Tenant warrants and represents that it has dealt with no broker in connection with the
consummation of this Lease, other than Colliers International and Irving Hughes (the "Brokers"), and in the event of any brokerage claims or liens,
other than by the Brokers, against Landlord or the Complex predicated upon or arising out of prior dealings with Tenant, Tenant agrees to defend the same and indemnify and hold Landlord harmless
against any such claim, and to discharge any such lien. Landlord warrants and represents that it has dealt with no broker in connection with the consummation of this Lease, other than the Brokers, and
Landlord agrees to pay the commissions of the Brokers pursuant to a separate agreement between Landlord and Colliers International. In the event of any brokerage claims against Tenant by either of the
Brokers arising from Landlord's breach of its agreement to pay said commissions, or by any other brokers predicated upon or arising out of prior dealings with Landlord, Landlord agrees to defend the
same and indemnify and hold Tenant harmless against any such claim. 

        10.10    OSHPAD Requirements.    Without limiting any other provision contained in this Lease, Tenant hereby
represents and warrants to Landlord that Tenant's operation of the Premises and the condition of the Premises shall not require any compliance with the requirements of, or certification of compliance
from, the California Office of Statewide Health Planning and Development ("OSHPAD") or any similar governmental certificates due to the nature of Tenant's operation of the Premises. Landlord shall not
be liable for, and Tenant shall indemnify, defend and hold Landlord harmless from and against all liabilities, damages, claims, costs and expenses (including, without limitation, reasonable attorneys'
fees and costs) arising in connection with, any failure of Tenant's operation of the Premises to comply with, or any failure of the Premises to comply with, the requirements of OSHPAD or other
similar or related governmental entities. In the event compliance with the requirements of OSHPAD or any other similar or related governmental entity is required in connection with Tenant's operation
of the Premises by Tenant or by any assignee or subtenant of Tenant, Tenant shall be solely responsible for the cost of making any alterations or taking any other necessary actions to cause such
compliance and Landlord shall have no liability in connection therewith. 

        10.11    Applicable Law and Construction.    This Lease shall be governed by and construed in accordance with the laws
of the state or district in which the Complex is located and if any provisions of this Lease shall to any extent be invalid, the remainder of this Lease shall not be affected thereby. Tenant expressly
acknowledges and agrees that Landlord has not made and is not making, and Tenant, in executing and delivering this Lease, is not relying upon, any warranties, representations, promises or statements,
except to the extent that the same are expressly set forth in this Lease or in any other written agreement which may be made between the parties concurrently with the execution and delivery of this
Lease and which shall expressly refer to this Lease. All understandings and agreements heretofore made between the parties are merged in this Lease and any other such written agreement(s) 

37

 

made
concurrently herewith, which alone fully and completely express the agreement of the parties and which are entered into after full investigation, neither party relying upon any statement or
representation not embodied in this Lease or any other such written agreement(s) made concurrently herewith. This Lease may be amended, and the provisions hereof may be waived or modified, only by
instruments in writing executed by Landlord and Tenant. The titles of the several Articles and Sections contained herein are for convenience only and shall not be considered in construing this Lease.
The submission of this document for examination and negotiation does not constitute an offer to lease, or a reservation of, or option for, the Premises, and Tenant shall have no right to the Premises
hereunder until the execution and delivery hereof by both Landlord and Tenant. Except as herein otherwise provided, the terms hereof shall be binding upon and shall inure to the benefit of the
successors and assigns, respectively, of Landlord and Tenant and, if Tenant shall be an individual, upon and to his heirs, executors, administrators, successors and assigns. If two or more persons or
parties are named as Tenant herein, (i) each of such persons or parties shall be jointly and severally liable for the obligations of the Tenant hereunder, and Landlord may proceed against any
one without first having commenced proceedings against any other of them and (ii) Landlord may require that all notices, requests, demands, consents, approvals or other communications delivered
by Tenant under the Lease must be executed by each person or party named as Tenant herein. Each term and each provision of this Lease to be performed by Tenant shall be construed to be both an
independent covenant and a condition and time is of the essence with respect to the exercise of any of Tenant's rights under this Lease. The reference contained to successors and assigns of Tenant is
not intended to constitute a consent to assignment of Tenant. Except as otherwise set forth in this Lease, any obligations of Tenant (including, without limitation, rental and other monetary
obligations, repair obligations and obligations to indemnify Landlord), shall survive the expiration or earlier termination of this Lease, and Tenant shall immediately reimburse Landlord for any
expense incurred by Landlord in curing Tenant's failure to satisfy any such obligation (notwithstanding the fact that such cure might be effected by Landlord following the expiration or earlier
termination of this Lease). 

[THE REST OF THIS PAGE IS INTENTIONALLY LEFT BLANK]

38

   
        WITNESS the execution hereof under seal on the day and year first above written. 

	 	 	Landlord:
	

 	
 	

Hub Properties Trust
	

 	
 	

By:	

/s/  JENNIFER B. CLARK      
 Jennifer B. Clark

Senior Vice President
	

 	
 	

Tenant:
	

 	
 	

DexCom, Inc.
	

 	
 	

By:	

/s/  STEVEN KEMPER      
 Name: Steven Kemper

Title: CFO, Assistant Secretary

39

EXHIBIT A  

 PLAN SHOWING THE PREMISES  

[See
attached copy.] 

  

  

EXHIBIT A-1  

 PLAN SHOWING THE PARKING SPACES  

[See
attached copy.] 

  

EXHIBIT B  

 RULES AND REGULATIONS  

        1.     The
sidewalks, entrances and driveways in or about the Complex shall not be obstructed by Tenant or used by Tenant for any purpose other than for access to the Premises
and the Complex. 

        2.     Tenant
shall not place objects against glass partitions, doors or windows which would be unsightly from the exterior of the Building. No signs, advertisements, placards,
pictures, names, notices, or lettering shall be exhibited, inscribed, painted or fixed by Tenant on any window or outside or inside of the Building or Complex without the prior consent of Landlord. 

        3.     All
window coverings shall be of a uniform shape, color, material and design as prescribed by Landlord and approved by Tenant, such approval not to be unreasonably
withheld. 

        4.     Tenant
shall not place a load upon any floor of the Building exceeding the lesser of the floor load which such floor was designed to carry or that allowed by law. 

        5.     No
additional or different locks or bolts shall be affixed on doors by Tenant without reasonable prior notice to Landlord and without providing Landlord with copies
thereof. Tenant shall return all keys to Landlord upon termination of Tenant's lease. 

        6.     Tenant
shall not use the Premises so as to cause any increase above normal insurance premiums on the Building. 

        7.     No
vehicles or animals (except a seeing-eye dog) shall be brought into or kept in or about the Premises. No space in the Building shall be used for the sale
of merchandise of any kind at auction or for storage thereof preliminary to such sale. 

        8.     Tenant
shall not engage or pay any employees of the Complex without approval from the Landlord. 

        9.     Tenant
shall cooperate with Landlord in minimizing loss and risk thereof from fire and associated perils. 

        10.   Tenant
shall, at Tenant's expense, provide artificial light and electric current for the Landlord and/or its contractors, agents and employees during the making of
repairs, alterations, additions or improvements in or to the Premises. 

        11.   The
water and wash closets and other plumbing fixtures shall not be used for any purposes other than those for which they were designed and constructed. Any equipment or
apparatus within the Premises, including, without limitation, x-ray effluent drains, shall be maintained by Tenant throughout the term hereof, at Tenant's sole cost and expense. 

        12.   Landlord
reserves the right to establish, modify and enforce parking rules and regulations, provided the same are reasonable, consistent with the type of parking rules
in effect in comparable office parks in the San Diego area, and apply uniformly to all tenants of the Complex. 

        13.   All
refuse from the Premises shall be disposed of in accordance with the requirements established therefor by Landlord for the Complex. 

        14.   Except
for the use of coffee makers and microwave ovens, no cooking shall be done or permitted by Tenant on the Premises. 

        15.   No
smoking is allowed in the Building (including the Premises) or any other building or structure in the Complex. 

        16.   No
Tenant shall make, or permit to be made, any noises which shall disturb or interfere with occupants of the Complex. 

        17.   The
requirements of Tenant to which it is entitled hereunder will be attended to only upon application at the Building office. Employees of Landlord shall not perform
any work or do anything outside of their regular duties unless under special written instructions from Landlord, and no 

 

employee
will admit any person (Tenant or otherwise) to any office, or sign acceptance of delivery for any Tenant, without written specific instructions from Tenant. 

        18.   Landlord
reserves the right at any time to rescind, alter or waive any rule or regulation at any time prescribed for the Building and to impose additional rules and
regulations when in its judgment reasonably exercised Landlord deems it necessary, desirable or proper for its best interest and for the best interest of tenants and other occupants and invitees
thereof. No alteration or waiver of any rule or regulation in favor of one Tenant shall operate as an alteration or waiver in favor of any other Tenant. Landlord shall not be responsible to any Tenant
for the non-observance or violation by any other Tenant however resulting of any rules or regulations at any time prescribed for the Complex. In the event of any conflict between these
Rules and Regulations, or any further or modified rules and regulations from time to time issued by Landlord, and the Lease provisions, the Lease provisions shall govern and control. 

2

EXHIBIT C  

 ALTERATIONS REQUIREMENTS  

A.    Generally    

        1.     All
alterations, installations or improvements ("Alterations") to be made by Tenant in, to or about the Premises,
including any Alterations to be made prior to Tenant's occupancy of the Premises for the Permitted Use, shall be made in accordance with the requirements of this Exhibit and with any additional
requirements stated in the Lease. 

        2.     All
submissions, inquiries approvals and other matters shall be processed through Landlord's Building manager or regional property manager. 

        3.     Additional
and differing provisions in the Lease, if any, will be applicable and will take precedence over the terms of this Exhibit. 

B.    Plans    

        1.     Before
commencing construction of any Alterations, Tenant shall submit for Landlord's written approval, either a description of the Alterations or drawings and
specifications for the Alterations as follows: 

	(i)
	Tenant
shall submit drawings and written specifications (collectively, "Plans") for all of Tenant's Alterations,
including mechanical, electrical and cabling, plumbing and architectural drawings. Drawings are to be complete, with full details and finish schedules, and shall be stamped by an AIA architect
licensed in the state or district in which the Complex is located certifying compliance with building codes.

	(ii)
	Tenant
may submit a complete description of Tenant's Alterations (including sketches or diagrams as necessary) in lieu of submitting Plans if the proposed Alterations
do not require Landlord's prior consent pursuant to Section 6.2.5 or if the Alterations meet all of the following criteria: (1) they are cosmetic in nature (e.g. painting, wallpapering,
installation of floor coverings, etc.), (2) they do not require a building permit, (3) they do not require work to be performed inside walls or above the ceiling of the Premises, and
(4) they will not affect the Building structure or mechanical, electrical, plumbing or HVAC systems. Notwithstanding that Tenant's proposed Alterations satisfy all of the preceding criteria,
upon review of Tenant's submission, Landlord shall have the right to require Tenant to submit Plans for all or any portion of the proposed Alterations. 

        2.     Landlord
shall review the description or Plans submitted by Tenant ("Tenant's Design Submission") and notify Tenant of
approval or disapproval. If Landlord disapproves Tenant's Design Submission, Landlord shall specify the reasons for its disapproval and Tenant shall revise Tenant's Design Submission to meet
Landlord's objections, and shall resubmit the same to Landlord as so revised until Tenant's Design Submission is approved by Landlord. No approval by Landlord of Tenant's
Design Submission shall constitute a waiver of any of the requirements of this Exhibit or the Lease. Tenant shall not make any changes to Tenant's Design Submission after
approval by Landlord, including changes required to obtain governmental permits, without obtaining Landlord's written approval in each instance. 

        3.     All
mechanical, electrical, structural and floor loading requirements shall be subject to approval of Landlord's engineers. Landlord also reserves the right to require
Tenant to submit copies of shop drawings for Landlord's review and approval. 

        4.     Before
commencing construction of any Alterations, Tenant shall provide Landlord with two (2) complete copies of Tenant's Design Submission in final form as
approved by Landlord. 

C.    Selection of Contractors and Subcontractors    

        Before
commencing construction of any Alterations, Tenant shall submit to Landlord the names of Tenant's general contractor (the "General
Contractor") and any subcontractors performing work on the 

 

electrical,
mechanical, plumbing or life-safety systems of the Building for Landlord's approval, such approval not to be unreasonably withheld, conditioned or delayed. If Landlord shall
reject the General Contractor or any such subcontractor, Landlord shall advise Tenant of the reasons(s) in writing and Tenant shall submit another selection to Landlord for Landlord's approval, such
approval not to be unreasonably withheld, conditioned or delayed. 

D.    Insurance    

        1.     Before
commencing construction of any Alterations, Tenant will deliver to Landlord: 

	(i)
	Four
(4) executed copies of the Insurance Requirements agreement in the form set forth in Exhibit D from the general contractor and, if requested by
Landlord, from the subcontractors (Landlord will return two fully executed copies to Tenant), and

	(ii)
	insurance
certificates for the General Contractor and subcontractors as required by Exhibit D, which shall include evidence of coverage for the indemnity
provided by the General Contractor or subcontractor executing such agreement. 

E.    Building Permit and Other Legal Requirements    

        1.     Before
commencing construction of any Alterations, Tenant shall furnish Landlord with a valid permit for the construction of the Alterations from the building department
or other agency having jurisdiction in the municipality in which the Building is located (unless the Alterations are of a cosmetic nature not requiring a building permit). Tenant shall keep the
original building permit posted on the Premises during the construction of the Alterations. 

        2.     Tenant
Design Submission, the Alterations, and the construction of the Alterations shall each be in strict compliance with (i) all applicable laws, codes, rules
and regulations, including, without limitation, the Americans with Disabilities Act, state and local health department requirements, and occupational health and safety laws and regulations (and no
approval of Tenant's Design Submission shall relieve Tenant of this obligation or invest Landlord with any responsibility for ensuring such compliance), and (ii) all building permits, consents,
licenses, variances, and approvals issued in connection with the Alterations. Tenant shall ensure that the General Contractor and all subcontractors have the requisite licenses to perform their work.
Tenant shall procure all permits, governmental approvals, licenses, variances and consents required for the Alterations and shall provide Landlord with a complete copy thereof promptly upon receipt of
same by Tenant. 

F.    Materials and Workmanship    

        1.     All
equipment and installations must be equal to the Building standard and all materials shall be new, commercial grade and of first-class quality. Any deviation from
these requirements will be permitted only if clearly indicated or specified on Tenant's Design Submission and approved by Landlord. 

        2.     Alterations
shall be constructed in a professional and good and workmanlike manner, in accordance with Tenant's Design Submission. 

        3.     The
General Contractor shall guaranty all materials and workmanship against defects for a period of not less than one (1) year from installation. Notwithstanding
any limitations contained in such guaranty or in any contract, purchase order or other agreement, during the entire term of the Lease, Tenant shall promptly repair or replace, at Tenant's cost, any
defective aspect of the Alterations except for insubstantial defects that do not adversely effect the Building or the appearance or rental value of the Premises, as determined by Landlord in its sole
discretion. 

        4.     Alterations
(other than upgrades of Building systems) must be compatible with the existing mechanical, plumbing, HVAC, electrical and life safety systems of the Building
(collectively the "Building Systems"). In the event any Alterations shall interfere with the proper functioning of any 

2

 

Building
System, Tenant shall promptly cause such repairs, replacements or adjustments to be made to the Alterations as are necessary to eliminate any such interference at Tenant's sole cost and
expense 

G.    Prosecution of the Work  

        1.     All
construction activities shall be conducted so as to avoid disturbance of other tenants. Landlord may require that all demolition and other categories of work that may
disturb other tenants of the Building be scheduled and performed on weekends or after normal working hours. and Tenant shall provide the Building manager with at least two Business Days' notice prior
to proceeding with such work. 

        2.     Alterations
costing in excess of $10,000 shall be performed under the supervision of a superintendent or foreman of the General Contractor at all times. 

        3.     The
General Contractor or HVAC subcontractor shall block off supply and return grilles, diffusers and ducts to keep dust from entering into the Premises HVAC system and
thoroughly clean all HVAC units in the work area at the completion of the Alterations. 

        4.     Construction
debris shall be stored in appropriate containers and removed from the construction area on a regular basis and the construction area shall be kept neat and
reasonably clean at all times. All construction debris is to be discarded in waste containment provided by the General Contractor only. No material or debris shall be stored outside the Building
without the prior written approval of the Landlord's Construction Representative. 

        5.     Landlord
shall have the right to instruct the General Contractor to deliver to Landlord, at Tenant's expense, any items to be removed from the Premises during the
construction of the Alterations. 

        6.     Tenant,
either directly or through the General Contractor, will immediately notify Landlord, in writing, of any damage to the Building caused by the General Contractor or
any subcontractors. Such damage shall be repaired within 72 hours unless otherwise directed by the Landlord in writing. Any damage that is not repaired may be repaired by Landlord at Tenant's
expense. 

        7.     The
General Contractor and all subcontractors shall cause their employees to adhere to all applicable Rules and Regulations of the Complex. 

        8.     Landlord
shall have the right to supervise and inspect the Alterations as the work progresses and to require Tenant to remove or correct any aspect of the Alterations
that does not substantially conform, in any material respect, to Tenant's Design Submission approved by Landlord. Such supervision and inspection shall be at Landlord's sole expense unless Landlord
reasonably determines that Tenant's Alterations do not conform to Tenant's Design Submission, in which case Tenant shall pay, as Additional Rent, Landlord's reasonable costs of all future supervision. 

H.    Documents to Be Furnished to Landlord Upon Completion of Tenant's Work  

        1.     Within
thirty (30) days after construction of the Alterations has been completed, except for so-called punch list items, Tenant shall furnish Landlord
with the following documents: 

	(i)
	record
"as built" drawings in paper and electronic (CADD) format showing all of the Alterations as actually constructed for all portions of the Alterations for which
drawings were submitted;

	(ii)
	if
Plans for the Alterations were prepared by an architect, a written certification from the architect confirming that the Alterations were completed in accordance with
the Plans and all applicable laws, codes, ordinances, and regulations; 

3

 

	(iii)
	full
and final lien waivers and releases executed by the General Contractor and all subcontractors and suppliers;

	(iv)
	if
the Alterations include any HVAC work, a properly executed air balancing report signed by a professional engineer showing that the HVAC system is properly balanced
for the season;

	(v)
	copies
of all warranties and guarantees received from the General Contractor, subcontractors and materials suppliers or manufacturers;

	(vi)
	copies
of all maintenance manuals, instructions and similar information pertaining to the operation and maintenance of equipment and fixtures installed in the Premises
as part of the Alterations; and

	(vii)
	a
copy of the final, permanent certificate of occupancy or amended certificate of occupancy for the Premises. 

4

EXHIBIT D  

 CONTRACTOR'S INSURANCE REQUIREMENTS  

Building:

Tenant:

Premises:

        The
undersigned contractor or subcontractor ("Contractor") has been hired by the tenant or occupant (hereinafter called
"Tenant") of the Building named above or by Tenant's contractor to perform certain work ("Work") for
Tenant in the Premises identified above. Contractor and Tenant have requested the undersigned landlord ("Landlord") to grant Contractor access to the
Building and its facilities in connection with the performance of the Work and Landlord agrees to grant such access to Contractor upon and subject to the following terms and conditions: 

        1.     Contractor
agrees to indemnify and save harmless the Landlord, and if Landlord is a general or limited partnership each of the partners thereof, and if Landlord is a
nominee trust the trustee(s) and all beneficiaries thereof, and all of their respective officers, employees and agents, from and against any claims, demands, suits, liabilities, losses and expenses,
including reasonable attorneys' fees, arising out of or in connection with the Work (and/or imposed by law upon any or all of them) because of personal injuries, including death, at any time resulting
therefrom and loss of or damage to property, including consequential damages, whether such injuries to person or property are claimed to be due to negligence of the Contractor, Tenant, Landlord or any
other party entitled to be indemnified as aforesaid except to the extent specifically prohibited by law (and any such prohibition shall not void this agreement but shall be applied only to the minimum
extent required by law). 

        2.     Contractor
shall provide and maintain at its own expense, until completion of the Work, the following insurance: 

        (a)   Worker's
Compensation and Employers Liability Insurance covering each and every workman employed in, about or upon the Work, as provided for in each and every statute
applicable to Workmen's Compensation and Employers' Liability Insurance. 

        (b)   Commercial
General Liability Insurance including coverages for Protective and Contractual Liability (to specifically include coverage for the indemnification clause of
this agreement) for not less than the following limits: 

	Bodily Injury:	 	$5,000,000 per person

$5,000,000 per occurrence
	

Property Damage:	
 	

$5,000,000 per occurrence

$5,000,000 aggregate

        (c)   Commercial
Automobile Liability Insurance (covering all owned, non-owned and/or hired motor vehicles to be used in connection with the Work) for not less
than the following limits: 

	Bodily Injury:	 	$5,000,000 per person

$5,000,000 per occurrence
	

Property Damage:	
 	

$5,000,000 per occurrence.

        Contractor
shall furnish a certificate from its insurance carrier or carriers to the Building office before commencing the Work, showing that it has complied with the above requirements
regarding insurance and providing that the insurer will give Landlord ten (10) days' prior written notice of the cancellation of any of the foregoing policies. 

 

        The
insurance provided in (b) and (c) above shall name Landlord as an additional insured. 

        3.     Contractor
shall require all of its subcontractors engaged in the Work to provide the following insurance: 

        (a)   Commercial
General Liability Insurance including Protective and Contractual Liability coverages with limits of liability at least equal to the limits stated in
paragraph 2(b). 

        (b)   Commercial
Automobile Liability Insurance (covering all owned, non-owned and/or hired motor vehicles to be used in connection with the Work) with limits of
liability at least equal to the limits stated in paragraph 2(c). 

        Upon
the request of Landlord, Contractor shall require all of its subcontractors engaged in the Work to execute an Insurance Requirements agreement in the same form as this Agreement. 

        Agreed
to and executed this    day of            , 20    . 

	Contractor:	 	Landlord:
	By:	 	 	 	By:	 	 
	 	 	
	 	 	 	

	 	 	Name:	 	 	 	Name:
	 	 	Title:	 	 	 	Title:

2

EXHIBIT E  

 CLERK'S CERTIFICATE  

        I, Steven Kemper, the duly elected and acting [Asst. Secretary] of DexCom, a Delaware corporation (the
"Corporation"), hereby certify that: 

        (A)  at
a meeting of the board of directors of the Corporation held on October 30, 2003 in accordance with law and the Bylaws of the Corporation the following
resolutions were duly adopted: 

VOTED:
a.    To approve a lease of approximately 23,000 rentable square feet of space for terms of 7 years with respect
to                        in the building commonly known as 555 Oberlin in
San Diego, which lease grants the Corporation an option to extend the term for 1 terms of 5 years each, substantially in the form of the draft presented at this meeting, a copy of which shall be
placed on file in the office of the [Secretary/Clerk] and be incorporated by reference in this vote; 

b.    To
authorize Steven Kemper and Andy Rasdal, or any one of them (each hereinafter referred to as a "Signatory"), to execute and deliver in the name and on behalf of the Corporation the
above-described lease and to execute and deliver all other documents, agreements and instruments, including, without limitation, notices of lease, and to take all other actions with respect to the
foregoing which any Signatory, in such Signatory's discretion, shall determine to be necessary or appropriate to effect or secure the transactions contemplated herein, the execution and delivery of
any of the foregoing or the taking of any such action to be conclusive evidence of such Signatory's determination and of the Signatory's authority so to do granted by this vote; 

        (B)  as
of this date the following individuals are duly elected and qualified officers of the Corporation holding at this date, the offices specified next to their names and
the signature next to each such name is such individual's true signature. 

	NAME
	 	OFFICE
	 	SIGNATURE

	Steven Kemper	 	CFO, Asst. Secretary	 	/s/ Steven Kemper

	

 	
 	

 	
 	

 
	
	 	
	 	

        (C)  The
form of lease attached to this Certificate is the form referred to in the foregoing vote. 

        (D)  The
resolutions set forth above are unmodified and continue to be in full force and effect and the Corporation has adopted no other resolutions in respect of the subject
matter thereof. 

        In
witness whereof, I have hereunto set my hand and affixed the seal of the Corporation this 3 day of December, 2003. 

	 	 	/s/Steven Kemper
 [Secretary/Clerk]

EXHIBIT F  

 PROPOSED LEASED SPACE

5555 Oberlin Drive, San Diego  

DEMOLITION SCOPE OF WORK

November 5, 2003  

        The scope of work shall include all labor, materials, tools, equipment and services to perform the following: 

	1.
	Disconnect
and safe-off all plumbing, piping, HVAC systems, fire sprinklers, fire alarm, and electrical services to prepare for demolition and removal of all areas shown
within the "orange' perimeter on the attached floor plan and all systems and services that are shared or cross-over to areas outside the "orange' perimeter.

	2.
	Demolish
and remove all plumbing fixtures, water, waste and vent lines, sinks, piping, entire exhaust systems, fume hoods, cold room, interior supply and return ductwork, dampers,
diffusers, registers, electrical conduit, wire, and electrical devices, light fixtures, telecom devices and cabling, walls, security system devices and wiring, all insulation, doors, windows,
flooring, grid and drywall ceilings, casework, cabinets, shelving, and furniture in all areas within the "orange' perimeter so, that all that remains are the following items:

	a.
	Clean
and smooth concrete slab free of all glue, anchors, and bolts.

	b.
	Clean
underside of roof deck plywood, beams, and joists free of insulation, supports, hangers, anchors, wires and nails.

	c.
	Clean
supports columns free of drywall, glue, anchors, and nails.

	d.
	All
rooftop air handlers, package units, heat pumps, associated controls and thermostats, associated rooftop platforms, ductwork, electrical services, gas services, filter banks, and
condensate drain lines.

	e.
	Removed
exhaust duct roof penetrations and fan platforms safed-off with leak free sheetmetal caps.

	f.
	Piping
roof penetrations from removed piping and vents repaired with matching decking and roofing materials.

	g.
	Exterior
air cooled chiller, electrical services, controls, and associated internal and external supply piping, circulation piping, hangers, supports, and valves.

	h.
	Exterior
Raypak boiler, electrical services, gas services, controls, and associated internal and external supply piping, circulation piping, hangers, supports, and valves.

	i.
	Two
smaller exterior generators, automatic transfer switches, electrical services to the generators and electrical services out to associated distribution panels.

	j.
	All
electrical distribution panels and subpanels with panel interiors Intact free of distribution wiring, but with electrical feeders from the main switchgear intact. Panels shall be
temporarily supported to the floor as needed once walls are removed.

	k.
	Underground
utility piping such as supply lines and sanitary sewer lines cut and plugged below slab on grade with concrete patched around piping after plugging.

	l.
	No
cross-over plumbing or HVAC services or distribution to areas outside the "orange' perimeter.

	m.
	Cross-over
electrical services for power and lighting fixtures and devices to areas outside the "orange' perimeter. If not possible, then services shall be terminated at
new junction boxes at the perimeter lines. 

 

	n.
	Main
domestic cold water lines above ceiling with valves and, caps at all branch lines.

	o.
	Walls
along 'green' hatched areas on the south side. of the floor plan will remain in place.

	3.
	Demolish
only one side drywall and insulation from walls highlighted in 'yellow' on the attached floor plan. The extend of demolition of these highlighted walls are subject to DexCom
visual inspection to determine if further removal of wall tracks, studs and second side drywall is necessary due to damage.

	4.
	Remove
the two yellow generators on the southwest perimeter of the building clouded in 'blue' on the floor plan, associated automatic transfer switches, conduit, junction boxes,
wiring, and concrete pad anchors. Patch conduit holes through building exterior walls with watertight materials matching the' exterior finish.

	5.
	Remove
fencing, bollards and concrete pad. Patch and repair area with asphalt to return space to its original condition. 

2

 
 

Exhibit G    
    

POST DEMOLITION
  AIR SAMPLING RESULTS  

Conducted for:
  Signal Research Division of Celgene Corporation  

Conducted at:
  5555 Oberlin Drive

San Diego, CA 92121  

Conducted by:
  Krista Wood, Industrial Hygienist III

Occupational Services, Inc.

6397 Nancy Ridge Drive

San Diego, CA 92121  

December 23, 2003  

Occupational Services, Inc.

[LOGO of Occupational Services, Inc.] 

1.0   INTRODUCTION  

        On December 16, 2003 and December 19, 2003, Occupational Services, Inc. ("OSI") conducted air sampling post laboratory demolition to provide
sufficient information regarding the nature and extent of contamination, if any, at the project address of 5555 Oberlin Drive, San Diego, CA 92121. 

2.0.  EXECUTIVE SUMMARY  

Airborne Lead  

        A total of six air samples were collected for airborne lead. The results of the laboratory analysis reported all lead samples less than the limit of detection of
0.38 ug. Each measurement was less than or equal to the outdoor sample; therefore, indoor contamination cannot be identified. Also each sample was far below the Cal/OSHA permissible exposure limit
(PEL) of 50 ug/m3. OSI recommends no further action. Please refer to Appendix A for air sampling results. 

Airborne Total Dust  

        A total of six air samples were collected for total dust and indicated concentrations ranging from none detected for all indoor air samples to 0.57
mg/m3 for the outdoor sample. Each measurement was less
than the outdoor sample; therefore, indoor contamination cannot be identified. Also each sample was below the level of quantitation of 0.05 mg except for the outdoor sample; which was 0.57
mg/m3. Each sample was far below the Cal/OSHA PEL of 10 mg/ m3. OSI recommends no further action. Please refer to Appendix B for air sampling results. 

Airborne Microbial (Total Fungal Spores)  

        A total of six air samples were collected for total fungal spores on December 16, 2003. A total of approximately eight spores were observed in Office 160
of Stachybotrys and none were detected in the outdoor sample. Also, elevated levels of  Aspergillus/Penicillium spores were found in Office 160. The
reported Stachybotrys and  Aspergillus/Penicillium samples are not particularly high in the office sample. However, the higher value indoors of
Stachybotrys and Aspergillus/Penicillium indicate that a source of  Stachybotrys and/or Aspergillus/Penicillium infestation is present. A total of three air samples were
collected from within the wall cavities in Office 160 on December 19, 2003 with a WallCheckTM. A total of approximately three spores of  Stachybotrys were found in the North wall and
approximately 41 spores of Aspergillus/Penicillium were
found in the West Wall. Even though the WallCheckTM indicated the presence of Stachybotrys and  Aspergillus/Penicillium spores, OSI suggests the
building owner conduct further testing in Room 160 to confirm mold grown. Please refer to
Appendix C for air sampling results. 

Airborne Total Volatile Organics  

        A total of six air samples were collected for total volatile organics. The results of the laboratory analysis reported all volatile organics at less than the
limit of detection of 10 ug. OSI recommends no further action. Please refer to Appendix D for air sampling results. 

3.0   BACKGROUND  

        This investigation consisted of inspections of the demolished space and testing for airborne total dust, lead, total fungal spores and total volatile organics. 

        OSI
conducted a visual inspection of the noted area on December 16, 2003 and found that the space had been removed of all porous materials within the construction area and there
were no visual signs of contamination, mold growth or water leaks. 

 

4.0   METHODS AND INSTRUMENTATION  

        OSI arrived at the project address, 5555 Oberlin Drive, San Diego, CA 92121, on December 16, 2003 at approximately 6:30 am. 

        OSI
collected six air samples for total lead, six air samples for total dust, six air samples for total fungal spores and six air samples for total volatile organics for analysis in the
following locations: 

	1.
	North
Office Space

	2.
	South
Office Space

	3.
	North
Construction Area

	4.
	South
Construction Area

	5.
	Outside
5555 Oberlin Drive

	6.
	Control

        On
December 19, 2003, OSI arrived at the project address at approximately 12:00 pm to obtain additional airborne microbial samples to determine the extent of contamination of  Stachybotrys and
Aspergillus/Penicillium. 

        OSI
collected three wall-check samples for total fungal spores in Office 160 in the East wall, West wall and North wall. The South wall was not checked because it is a
concrete structure. 

Airborne Lead  

        OSI installed the Aircheck® 52 Sampler pump in six designated areas throughout the facility. Unweighed 0.8 um MCE cassettes were connected upstream of
each sampling pump. Pre and post calibration of each sampling pump was conducted with a precision rotameter and was within ± 5% of 2.0 liters per minute
(L/min). The procedure for sample collecting was followed as recommended by NIOSH 7300. Each sample was collected for four hours at an average flow rate of 2.0 L/min. Four indoor air samples, an
outdoor sample and a field blank were analyzed. 

        The
samples were submitted along with a chain of custody and shipped priority overnight via FedEx to Galson Laboratories (accredited by the American Industrial Hygiene Association) in
Syracuse, New York. The method of analysis for the Lead samples was NIOSH 7300. 

Airborne Total Dust  

        OSI installed the Airchece® 52 Sampler pump in six designated areas throughout the facility. Preweighed 5 um PVC cassettes were connected upstream of
each sampling pump. Pre and post calibration of each sampling pump was conducted with a precision rotameter and was within ± 5% of 2.0 liters per minute
(L/min). The procedure for sample collecting was followed as recommended by NIOSH 0500. Each sample was collected for sixty minutes at an average flow rate of 2.0 L/min. Four indoor air samples, an
outdoor sample and a field blank were analyzed. 

        The
samples were submitted along with a chain of custody and shipped priority overnight via FedEx to Galson Laboratories (accredited by the American Industrial Hygiene Association) in
Syracuse, New York. The method of analysis for the total dust samples was NIOSH 0500. 

Airborne Microbial (Total Fungal Spores)  

        On December 16, 2003, OSI used the Air-O-Cell spore trap sampler, which is a particulate sampling cassette designed for the rapid
collection and analysis of a wide range of airborne aerosols that include mold spores. Airborne particles are drawn through the cassette, directed to the slide, and 

2

 

impacted
on an adhesive collection media. The Air-O-Cell Cassettes (expiration date: 11/04) were installed in five designated areas. Pre and post calibration of the sampling
pump (serial # 1249011) was within ± 5% of 15 liters per minute (1/min). The sampling method used was written by Aerotech Laboratories. Each sample was
collected for five minutes at a flow rate of 15 1/min. Because of the ubiquity of fungi, a negative control was also submitted and evaluated against the samples collected. A total of six samples were
collected for the purpose of determining the presence of viable fungi. 

        On
December 19, 2003, OSI used the Air-O-Cell spore trap sampler and a WallCheckTM. The WallCheckTM is a precision-tooled adapter
specially designed to work with Air-O-Cell Cassettes and developed to locate and identify hidden gross fungal amplification with limited physical destruction of building
interiors. Air is drawn at a flow rate of 15 liters per minute (1/min) through 1/4" tubing and impacted onto an Air-O-Cell Cassette. The WallCheckTM
adapter is designed for sampling wall cavities for viable and nonviable fungi. The Air-O-Cell Cassettes (expiration date: 11/04) were installed in the East wall, West wall and
South wall. Pre and post calibration of the sampling pump (serial # 1249011) was within ± 5% of 15 liters per minute (1/min). The sampling method used
was written by Aerotech Laboratories. Each sample was collected for two minutes at a flow rate of 15 1/min. 

        The
samples were submitted along with a chain of custody and shipped priority overnight via FedEx to Aerotech Laboratories (accredited by the American Association of Laboratory
Accreditation) in Phoenix, Arizona. The slides of each cassette are removed for direct examination and identification. Samples at Aerotech Laboratories are analyzed via light microscope at 600X
magnification with 100% of the sample being analyzed. 

Airborne Total Volatile Organics  

        OSI installed the Aircheck® 52 Sampler pump in six designated areas throughout the facility. Coconut Shell Charcoal tubes (Catalog
No. 226-01) were connected upstream of
each sampling pump. Pre and post calibration of each sampling pump was conducted with a precision rotameter and was within ± 5% of 0.02 liters per
minute (L/min). The samples were taken in accordance with the report entitled "ASTM Standard Practice for Sampling Atmospheres to Collect Organic Compound Vapors (Activated Charcoal Tube Adsorption
Method). The procedure for sample collecting was followed as recommended by the report. Each sample was collected for 100 minutes at an average flow rate of 0.02 L/min. Four indoor air samples, an
outdoor sample and a field blank were analyzed. 

        The
samples were submitted along with a chain of custody and shipped priority overnight via FedEx to Galson Laboratories (accredited by the American Industrial Hygiene Association) in
Syracuse, New York. The method of analysis for the total volatile organic samples was NIOSH 1500/1501. 

5.0   DISCUSSION  

Airborne Lead  

        Cal/OSHA has set permissible exposure limit (PEL) for lead at 50 ug/m3. The PEL is defined as average concentration for a conventional 8 hour
work day and 40 hour work week, to which it is believed that nearly all workers may be reportedly exposed, day after day without adverse health effects. In this case, the samples collected from
the facility were evaluated against samples collected from the outdoors. 

Airborne Total Dust  

        Cal/OSHA has set permissible exposure limit (PEL) for dust at 10 mg/m3. The PEL is defined as average concentration for a conventional 8 hour
work day and 40 hour work week, to which it is believed that nearly all workers may be reportedly exposed, day after day without adverse health 

3

 

effects.
In this case, the samples collected from the facility were evaluated against samples collected from the outdoors. 

Airborne Microbial (Total Fungal Spores)  

        Standards do not exist with respect to acceptable air and surface concentrations; therefore, guidelines indicate that suspect area samples should be evaluated
against samples collected from non-suspect areas and from the outdoors. OSI evaluates the total quantity and relative amounts of the different genus identified, and compares indoor types
and levels with those found in the outdoor environment. 

        The
general guideline to follow is that the concentration and types of spores in the inside sample should be similar to or lower than the concentration and types of spores found in the
outdoor sample. Due to the high variability in results; this test is mainly useful as a "check" to alert one to potential problems that might have been missed by visual inspection.  NOTE: Accurate measurements of true airborne
concentrations requires multiple samples taken during different times, and it can involve complex statistical
analysis. The category Aspergillus / Penicillium are small (1-3 microns), round, colorless spores. A culture sample would be necessary to differentiate between
them. 

        Levels
in excess of the outdoor sample do not necessarily imply that the conditions are unsafe or hazardous. The type and concentrations of the airborne microorganisms will determine the
hazard. 

Airborne Total Volatile Organics  

        Standards do not exist with respect to acceptable air concentrations to total volatile organics; therefore, guidelines indicate that suspect area samples should
be evaluated against samples collected from the outdoors. Cal/OSHA has set permissible exposure limit (PEL) for n-hexane (a volatile organic) at 50 ppm. All results are less than 0.1 ppm.
No volatile organics were found. 

6.0   RESULTS CONCLUSION AND RECOMMENDATION  

Airborne Lead  

        Each measurement is below the level of quantitation of 0.38 ug and far below the Cal/OSHA PEL for lead of 50 ug/m3. OSI recommends no further
action. The results are presented in Appendix A. 

Airborne Total Dust  

        The total dust concentration for the outdoor air sample was 0.57 mg/m3. The total dust concentrations for the indoor air samples were all below the
level of quantitation of <0.05 mg. The mass in the control sample was undetected. All samples are far below the Cal/OSHA PEL for total dust of 10 mg/m3. OSI recommends no
further action. The results are presented in Appendix B. 

Airborne Microbial (Total Fungal Spores)  

        A total of approximately 8 spores were observed in Office 160 of Stachybotrys and none were detected on the
outdoor sample. Also, elevated levels of Aspergillus/Penicillium spores were found in Office 160 for the sampling event conducted on  December 16, 2003. The reported Stachybotrys and  Aspergillus/Penicillium values are not particularly high in the office sample. However, the higher value indoors of
 Stachybotrys and Aspergillus/Penicillium indicate that a source of  Stachybotrys and/or Aspergillus/Penicillium infestation is present. 

        A
total of approximately three spores of Stachybotrys were found in the North wall and approximately 41 spores of  Aspergillus/Penicillium were found in the
West Wall for the sampling event conducted on December 19,
2003. Even though the WallCheckTM indicated the presence of Stachybotrys

4

 

and  Aspergillus/Penicillium spores, OSI suggests the building owner conduct further testing in Room 160 to confirm mold grown. Please refer to
Appendix C for air sampling results. 

Airborne Total Volatile Organics  

        The total volatile organic concentration for the outdoor air sample was < 10 ug. The total volatile organic concentrations for the indoor air samples
were each < 10 ug. The mass in the control sample was undetected and the limit of quantitation was 10 ug (each measurement is below level of quantitation). OSI recommends no further action.
The results are presented in Appendix D. 

	

Prepared by:	
 	

Reviewed & Approved by:
	Occupational Services, Inc.	 	Occupational Services, Inc.
	

/s/  KRISTA WOOD      
 Krista Wood, Industrial Hygienist III, CIAQI

Certified Indoor Air Quality Technician

Board-Certified by the Association of Energy Engineers	
 	

/s/  JEFF SILVERS      
 Jeff Silvers, MPH, CIH, CSP

Vice President

5

 
 
 

Appendix A
  Sampling Results—Airborne Lead    
    

	Sample ID#
 
	 	Location
	 	Lab ID #
	 	Air Volume

m3
	 	Total ug
	 	Concentration

mg/ m3

	Cassette #3	 	North Administration	 	L100059-1	 	0.4512	 	< 0.38	 	< 0.8
	Cassette #1	 	North Construction	 	L100059-2	 	0.4416	 	< 0.38	 	< 0.9
	Cassette #5	 	South Construction	 	L100059-3	 	0.4464	 	< 0.38	 	< 0.8
	Cassette #6	 	Office 160	 	L100059-4	 	0.4416	 	< 0.38	 	< 0.9
	Cassette #4	 	Outside	 	L100059-5	 	0.4296	 	< 0.38	 	< 0.9
	Cassette #2	 	Control	 	L100059-6	 	NA	 	< 0.38	 	NA

	

 	
 	

 	
 	

 
	

Level of quantitation:	
 	

0.38 ug	
 	

 
	Analytical Method:	 	NIOSH 7300	 	 
	OSHA PEL (TWA):	 	50 ug/ m3	 	 
	Collection Media:	 	Filter	 	 
	

 	
 	

 	
 	

 

	 
	 	 

	<	 	Less Than
	NA	 	Not Applicable
	ug	 	Micrograms
	m3	 	Cubic Meters

6

 
 
 

Appendix B
  Sampling Results—Airborne Total Dust    
    

	Sample ID#
 
	 	Location
	 	Lab ID #
	 	Air Volume

m3
	 	Total ug
	 	Concentration

mg/ m3

	196471	 	North Administration	 	L100058-1	 	0.1062	 	< 0.05	 	< 0.5
	196472	 	North Construction	 	L100058-2	 	0.1062	 	< 0.05	 	< 0.5
	196470	 	South Construction	 	L100058-3	 	0.1062	 	< 0.05	 	< 0.5
	196469	 	Office 160	 	L100058-4	 	0.1062	 	< 0.05	 	< 0.5
	196467	 	Outside	 	L100058-5	 	0.1128	 	0.064	 	0.57
	196468	 	Control	 	L100058-6	 	NA	 	< 0.05	 	NA

	

 	
 	

 
	

Level of quantitation:	
 	

0.05 mg
	Analytical Method:	 	NIOSH 0500
	OSHA PLI.. (TWA):	 	I0 mg/ m3
	Collection Media:	 	PVC PW
	

 	
 	

 

	 
	 	 

	<	 	Less Than
	NA	 	Not Applicable
	mg	 	Milligrams
	m3	 	Cubic Meters

7

 

 
 

Appendix C
  Sampling Results—Total Fungal Spores    
    

December 16, 2003  

	Sample

ID#
	 	Location
	 	Total

Count
	 	*Results
	 	*Altemaria
	 	*Amerospores
	 	*Ascospores
	 	*Aspergillus/

Penicillium-

Like
	 	Basidiospores
	 	*Bipolaris/

Dreschlera
	 	*Cladosporium
	 	*Oidium/

Peronospora
	 	*Smuts/

Myxomycetes/

Periconia
	 	*Stachybotrys
	 	*Unclassified

Conidia

	1.	 	North Administration	 	30	 	400	 	—	 	213	 	53	 	—	 	53	 	13	 	67	 	—	 	—	 	 	 	—
	2.	 	North Construction	 	92	 	1227	 	—	 	813	 	53	 	160	 	40	 	—	 	93	 	—	 	13	 	—	 	53
	3.	 	South Construction	 	57	 	760	 	—	 	373	 	40	 	133	 	53	 	—	 	133	 	13	 	—	 	—	 	13
	4.	 	Office 160	 	131	 	1747	 	—	 	480	 	80	 	827	 	27	 	—	 	200	 	—	 	—	 	107	 	27
	5.	 	Outside	 	134	 	1787	 	13	 	627	 	133	 	173	 	53	 	—	 	693	 	—	 	13	 	 	 	80
	6.	 	Control	 	—	 	—	 	—	 	—	 	—	 	—	 	—	 	—	 	—	 	—	 	—	 	—	 	—

December 19, 2003  

	Sample

ID#
	 	Location
	 	Total

Count
	 	*Results
	 	*Altemaria
	 	*Amerospores
	 	*Ascospores
	 	*Aspergillus/

Penicillium-

Like
	 	Basidiospores
	 	*Chaetomium
	 	*Cladosporium
	 	*Stachybotrys
	 	*Unclassified

Conidia

	1.	 	Office 160 East Wall	 	42	 	1400	 	33	 	—	 	233	 	700	 	100	 	167	 	167	 	—	 	—
	2.	 	Office 160 West Wall	 	73	 	2433	 	—	 	33	 	33	 	1367	 	433	 	333	 	233	 	—	 	—
	3.	 	Office 160 North Wall	 	29	 	967	 	—	 	233	 	100	 	133	 	167	 	33	 	167	 	100	 	33

	*
	All
results are reported in Counts/m3 

8

 
 
 

Appendix D
  Sampling Results—Airborne Total Volatile Organics    
    

	Sample ID#
 
	 	Location
	 	Lab ID#
	 	Air Volume

liter
	 	Front

ug
	 	Back

ug
	 	Total

ug
	 	Conc.

mg/m3
	 	Conc.

ppm

	North Admin #1	 	North Administration	 	L100060-1	 	20	 	< 10	 	< 10	 	< 10	 	< 0.5	 	< 0.1
	North Const. #2	 	North Construction	 	L100060-2	 	20	 	< 10	 	< 10	 	< 10	 	< 0.5	 	< 0.1
	South Const. #3	 	South Construction	 	L100060-3	 	20	 	< 10	 	< 10	 	< 10	 	< 0.5	 	< 0.1
	Office 160 #4	 	Office 160	 	L100060-4	 	20	 	< 10	 	< 10	 	< 10	 	< 0.5	 	< 0.1
	Outside #5	 	Outside	 	L100060-5	 	20	 	< 10	 	< 10	 	< 10	 	< 0.5	 	< 0.1
	Control #6	 	Control	 	L100060-6	 	NA	 	< 10	 	< 10	 	< 10	 	NA	 	NA

	

 	
 	

 
	

Level of quantitation:	
 	

10 ug
	Analytical Method:	 	NIOSH 1500/1501; GC/FID
	OSHA PEL (TWA):	 	NA
	Collection Media:	 	Charcoal

	 
	 	 

	<	 	Less Than
	NA	 	Not Applicable
	ug	 	Micrograms
	m3	 	Cubic Meters
	ppm	 	Parts per Million

9

QuickLinks

SORRENTO VALLEY BUSINESS PARK LEASE FROM HUB PROPERTIES TRUST, a Maryland Real Estate Investment Trust, TO DEXCOM, INC, a Delaware corporation. 5555 Oberlin Drive San Diego, California 92121

Exhibit G

Appendix A Sampling Results—Airborne Lead

Appendix B Sampling Results—Airborne Total Dust

Appendix C Sampling Results—Total Fungal Spores

Appendix D Sampling Results—Airborne Total Volatile Organics

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