Document:

Registration Rights Agreement

 Exhibit 10.103 
  
 Execution Copy 
  
 REGISTRATION RIGHTS AGREEMENT 
  
 This Registration Rights Agreement (the “Agreement”) is made and entered into as of this 19th day of April, 2004 by and
among INCARA PHARMACEUTICALS CORPORATION, a Delaware corporation (the “Company”), the “Investors” named in that certain Purchase Agreement, dated April 19, 2004, by and among the Company and the Investors
(the “Purchase Agreement”), and SCO Securities LLC, a Delaware limited liability company (the “Placement Agent”). Capitalized terms not otherwise defined herein shall have the meanings ascribed thereto
in the Purchase Agreement. 
  
 The parties hereby agree as
follows: 
  
 1. Certain Definitions. 
  
 As used in this Agreement, the following terms shall have the following
meanings: 
  
 “Affiliate” shall mean, with
respect to any person, any other person which directly or indirectly Controls, is Controlled by, or is under common Control with, such person. 
  
 “Business Day” shall mean a day, other than a Saturday or Sunday, on which banks in New York City are open for the general transaction of
business. 
  
 “Common Stock” shall mean the
Company’s common stock, par value $0.001 per share, and any securities into which such shares may hereinafter be reclassified. 
  
 “Control” means the possession, direct or indirect, of the power to direct or cause the direction of the management and policies of a
person, whether through the ownership of voting securities, by contract or otherwise. 
  
 “Holders” shall mean the Investors, the Placement Agent and any Affiliate or permitted transferee thereof who is a subsequent holder of any Investor Warrants, the Placement Agent Warrants or
Registrable Securities. 
  
 “Investors” shall
mean the Investors identified in the Purchase Agreement. 
  
 “Prospectus” shall mean the prospectus included in any Registration Statement, as amended or supplemented by any prospectus supplement, with respect to the terms of the offering of any portion of the Registrable Securities
covered by such Registration Statement and by all other amendments and supplements to the prospectus, including post-effective amendments and all material incorporated by reference in such prospectus. 
  
 “Register,” “registered” and
“registration” refer to a registration made by preparing and filing a Registration Statement or similar document in compliance with the 1933 Act (as defined below), and the declaration or ordering of effectiveness of such
Registration Statement or document. 
  
 “Registrable
Securities” shall mean the shares of Common Stock issuable (i) pursuant to the Purchase Agreement, (ii) upon the exercise of the Investor Warrants, (iii) upon exercise of the Placement Agent Warrants, and (iv) issuable with respect to or in
exchange for Registrable Securities; provided, that, a security shall cease to be a Registrable Security upon sale pursuant to a Registration Statement. 

 “Registration Statement” shall mean any registration statement of the Company filed
under the 1933 Act that covers the resale of any of the Registrable Securities pursuant to the provisions of this Agreement, amendments and supplements to such Registration Statement, including post-effective amendments, and all exhibits and all
material incorporated by reference in such Registration Statement. 
  
 “SEC” shall mean the U.S. Securities and Exchange Commission. 
  
 “1933 Act” shall mean the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder. 
  
 “1934 Act” shall mean the Securities Exchange Act of 1934, as amended, and the rules and regulations
promulgated thereunder. 
  
 2. Registration. 
  
 (a) Registration Statements. 
  
 (i) Promptly following the closing of the purchase and sale of the
securities contemplated by the Purchase Agreement (the “Closing Date”), but in no event after May 14, 2004 (the “Filing Deadline”), the Company shall prepare and file with the SEC one Registration
Statement on Form S-1, covering the resale of all of the Registrable Securities without regard to any limitation on the exercise of the Investor Warrants or the Placement Agent Warrants. Such Registration Statement also shall cover, to the extent
allowable under the 1933 Act and the rules promulgated thereunder (including Rule 416), such indeterminate number of additional shares of Common Stock resulting from stock splits, stock dividends or similar transactions with respect to the
Registrable Securities. The Company shall use its reasonable best efforts to obtain from each person (other than Ruffin Woody and Elan Corporation, plc) who has piggyback registration rights a waiver of those rights with respect to the Registration
Statement. The Registration Statement (and each amendment or supplement thereto, and each request for acceleration of effectiveness thereof) shall be provided in accordance with Section 3(c) to the Holders and Placement Agent Counsel prior to its
filing or other submission. If a Registration Statement covering the Registrable Securities is not filed with the SEC on or prior to the Filing Deadline, the Company will make pro rata payments to each Holder, as liquidated damages and not as a
penalty, in an amount equal to 1.0% of the aggregate amount invested by such Holder (for purposes of this Agreement, the Placement Agent shall be deemed to have invested an amount equal to ten percent (10%) of the aggregate purchase price of the
Shares sold in the Private Placement, and for all other Holders, the amount invested by a Holder shall include the purchase price of the Common Stock acquired by such Holder and shall exclude any amount attributable to the Investor Warrants acquired
by such Holder in the Private Placement) for each 10-day period or pro rata for any portion thereof following the date by which such Registration Statement should have been filed for which no Registration Statement is filed with respect to the
Registrable Securities. Such payments shall be in partial compensation to the Holders, and shall not constitute the Holders’ exclusive remedy for such events. Such payments shall be made to each Holder in cash. The amounts payable as liquidated
damages pursuant to this paragraph shall be payable in lawful money of the United States, and amounts payable as liquidated damages shall be paid within two (2) Business Days of the last day of each such 10-day period during which the Registration
Statement should have been filed for which no Registration Statement was filed with respect to the Registrable Securities. 
  

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 (ii) Additional Registrable Securities. Upon the written demand of any Holder and upon any change
in the “Warrant Price” (as that term is defined in the Investor Warrants and the Placement Agent Warrants) or any change in the number of “Warrant Shares” (as that term is defined in the Investor Warrants and the Placement Agent
Warrants) purchasable under the Investor Warrants or the Placement Agent Warrants, as the case may be, such that additional shares of Common Stock become issuable upon the exercise of any such warrants, the Company shall prepare and file with the
SEC one or more Registration Statements on Form S-3 (or, if Form S-3 is not then available to the Company, on such form of Registration Statement as is then available to effect a registration for resale of such additional shares of Common Stock (the
“Additional Shares”)) covering the resale of the Additional Shares, but only to the extent the Additional Shares are not at the time covered by an effective Registration Statement. Such Registration Statement also shall
cover, to the extent allowable under the 1933 Act and the rules promulgated thereunder (including Rule 416), such indeterminate number of additional shares of Common Stock resulting from stock splits, stock dividends or similar transactions with
respect to the Additional Shares. The Company shall use its best efforts to obtain from each person (other than Ruffin Woody and Elan Corporation, plc) who has piggyback registration rights a waiver of those rights with respect to such Registration
Statement. The Registration Statement (and each amendment or supplement thereto, and each request for acceleration of effectiveness thereof) shall be provided in accordance with Section 3(c) to the Holders and their counsel prior to its filing or
other submission. If a Registration Statement covering the Additional Shares is required to be filed under this Section 2(a)(ii) and is not filed with the SEC within twenty (20) days of the request of any Holder, the Company will make pro rata
payments to each Holder, as liquidated damages and not as a penalty, in an amount equal to 1.0% of the aggregate amount invested by such Holder (for purposes of this Agreement, the Placement Agent shall be deemed to have invested an amount equal to
ten percent (10%) of the aggregate purchase price of the Shares sold in the Private Placement, and for all other Holders, the amount invested by a Holder shall include the purchase price of the Common Stock acquired by such Holder and shall exclude
any amount attributable to the Investor Warrants acquired by such Holder in the Private Placement) for each 20-day period or pro rata for any portion thereof following the date by which such Registration Statement should have been filed for which no
Registration Statement is filed with respect to the Additional Shares. The amounts payable as liquidated damages pursuant to this paragraph shall be payable in lawful money of the United States, and amounts payable as liquidated damages shall be
paid within two (2) Business Days of the last day of each such 20-day period during which the Registration Statement should have been filed for which no Registration Statement was filed with respect to the Additional Shares. 
  
 (b) Expenses. The Company will pay all expenses associated with each
registration, including filing and printing fees, counsel and accounting fees and expenses, costs associated with clearing the Registrable Securities for sale under applicable state securities laws and listing fees, but excluding the fees and
disbursements of more than one law firm serving as counsel to the Holders and more than one law firm serving as counsel to the Placement Agent, and discounts, commissions, fees of underwriters, selling brokers, dealer managers or similar securities
industry professionals with respect to the Registrable Securities being sold. 
  

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 (c) Effectiveness. 
  
 (i) The Company shall use its best efforts to have the Registration Statement declared effective not later than the earlier
to occur of (y) 120 days after the date of filing of such Registration Statement, or (z) five (5) Business Days following the Company’s receipt of a no-review letter from the SEC relating to the Registration Statement; provided,
however, if the Registration Statement is not declared effective within the time period set forth above, the Company shall continue to use its best efforts to have the Registration Statement declared effective as soon as possible thereafter.
If (A) the Registration Statement is not declared effective in accordance with the preceding sentence, or (B) after a Registration Statement has been declared effective by the SEC sales cannot be made pursuant to such Registration Statement for any
reason (including, without limitation, by reason of a stop order, or the Company’s failure to update the Registration Statement), but except as excused pursuant to subsection (ii) below, then the Company will make pro rata payments to each
Holder, as liquidated damages and not as a penalty, in an amount equal to 1.0% of the aggregate amount invested by such Holder (for purposes of this Agreement, the Placement Agent shall be deemed to have invested an amount equal to ten percent (10%)
of the aggregate purchase price of the Shares sold in the Private Placement, and for all other Holders, the amount invested by a Holder shall include the purchase price of the Common Stock acquired by such Holder and shall exclude any amount
attributable to the Investor Warrants acquired by such Holder in the Private Placement) for each 10-day period or pro rata for any portion thereof following the date (1) by which such Registration Statement should have been effective as described in
(A) above or (2) sales cannot be made pursuant to such Registration Statement after it has been declared effective as described in (B) above (the “Blackout Period”). Such payments shall be in partial compensation to the
Holders. The Blackout Period shall terminate upon (x) the effectiveness of the Registration Statement in the case of (A) above; and (y) the Registration Statement again being available for sales by the Holders in the case of (B) above. The amounts
payable as liquidated damages pursuant to this paragraph shall be payable in lawful money of the United States, and amounts payable as liquidated damages shall be paid within two (2) Business Days of the last day of each 10-day period following the
commencement of the Blackout Period until the termination of the Blackout Period. 
  
 (ii) For not more than twenty-five (25) consecutive days or for a total of not more than forty-five (45) days in any twenty-four (24) month period, the Company may delay the disclosure of material non-public
information concerning the Company, by terminating or suspending effectiveness of any registration contemplated by this Section 2, if the disclosure of such material non-public information at the time is not, in the good faith opinion of the
Company, in the best interests of the Company (an “Allowed Delay”); provided, that the Company shall promptly (a) notify the Holders in writing of the existence of (but in no event, without the prior written consent of
a Holder, shall the Company disclose to such Holder any of the facts or circumstances regarding) material non-public information giving rise to an Allowed Delay, and (b) advise the Holders in writing to cease all sales under the Registration
Statement until the end of the Allowed Delay. 
  
 (d)
Underwritten Offering. If any offering pursuant to a Registration Statement filed pursuant to Section 2(a) hereof involves an underwritten offering, the Company shall have the right to select an investment banker and manager to administer the
offering, which investment banker or manager shall be reasonably satisfactory to a majority of the Holders. 
  

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 3. Company Obligations. The Company will use its best efforts to effect the registration of the
Registrable Securities in accordance with the terms hereof, and pursuant thereto the Company will, as expeditiously as possible: 
  
 (a) use its best efforts to cause such Registration Statement to become effective and to remain continuously effective for a period that will terminate
upon the date on which all Registrable Securities covered by such Registration Statement, as amended from time to time, have been sold or at such time as all Registrable Securities held by all Investors can be sold in any three (3) month period
without regard to the volume limitations of Rule 144 of the 1933 Act; 
  
 (b) prepare and file with the SEC such amendments and post-effective amendments to the Registration Statement and the Prospectus as may be necessary to keep the Registration Statement effective for the period specified in Section 3(a) and
to comply with the provisions of the 1933 Act and the 1934 Act with respect to the distribution of all Registrable Securities; 
  
 (c) provide copies to and permit Placement Agent Counsel to review each Registration Statement and all amendments and supplements thereto no fewer than
eight (8) days prior to their filing with the SEC and not file any document to which such counsel reasonably objects within four (4) days following receipt by the Holders and counsel designated by the Holders of such Registration Statement and/or
amendments and supplements thereto; 
  
 (d) send to the Holders
and Placement Agent Counsel (i) promptly after the same is prepared and publicly distributed, filed with the SEC, or received by the Company (but not later than two (2) Business Days after the filing date, receipt date or sending date, as the case
may be), at least five (5) copies of any Registration Statement and any amendment thereto, each preliminary prospectus and Prospectus and each amendment or supplement thereto, and each letter written by or on behalf of the Company to the SEC or the
staff of the SEC, and each item of correspondence from the SEC or the staff of the SEC, in each case relating to such Registration Statement (other than any portion thereof which contains information for which the Company has sought confidential
treatment), and (ii) such number of copies of a Prospectus, including a preliminary prospectus, and all amendments and supplements thereto and such other documents as each Holder may reasonably request in order to facilitate the disposition of the
Registrable Securities owned by such Holder, which in any event, shall not exceed ten (10) Prospectuses; 
  
 (e) in the event the Company selects an underwriter for the offering, the Company shall enter into and perform its reasonable obligations under an
underwriting agreement, in usual and customary form, including, without limitation, customary indemnification and contribution obligations, with the underwriter of such offering; 
  
 (f) if required by the underwriter, the Company shall furnish, on the effective date of the Registration Statement (i) an
opinion, dated as of such date, from 
  

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 independent legal counsel representing the Company for purposes of such Registration Statement, in form, scope and
substance as is customarily given in an underwritten public offering, addressed to the underwriter and (ii) a letter, dated such date, from the Company’s independent certified public accountants in form and substance as is customarily given by
independent certified public accountants to underwriters in an underwritten public offering, addressed to the underwriter and the Holders; 
  
 (g) use its reasonable best efforts to prevent the issuance of any stop order or other suspension of effectiveness and, if such order is issued, obtain
the withdrawal of any such order at the earliest possible moment; 
  
 (h) prior to any public offering of Registrable Securities, use its reasonable best efforts to register or qualify or cooperate with the Holders and their counsel in connection with the registration or qualification of such Registrable
Securities for offer and sale under the securities or blue sky laws of such jurisdictions reasonably requested by the Holders and do any and all other reasonable acts or things necessary or advisable to enable the distribution in such jurisdictions
of the Registrable Securities covered by the Registration Statement; 
  
 (i) cause all Registrable Securities covered by a Registration Statement to be listed on each securities exchange, interdealer quotation system or other market on which similar securities issued by the Company are then listed; 

 
 (j) immediately notify the Holders, at any time when a Prospectus
relating to the Registrable Securities is required to be delivered under the 1933 Act, upon discovery that, or upon the happening of any event as a result of which, the Prospectus included in such Registration Statement, as then in effect, includes
an untrue statement of a material fact or omits to state any material fact required to be stated therein or necessary to make the statements therein not misleading in light of the circumstances then existing, and at the request of any such holder,
promptly prepare and furnish to such holder a reasonable number of copies of a supplement to or an amendment of such Prospectus as may be necessary so that, as thereafter delivered to the purchasers of such Registrable Securities, such Prospectus
shall not include an untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the statements therein not misleading in light of the circumstances then existing; and 
  
 (k) otherwise use its best efforts to comply with all applicable rules and
regulations of the SEC under the 1933 Act and the 1934 Act and take such other actions as may be reasonably necessary to facilitate the registration of the Registrable Securities hereunder; and make available to its security holders, as soon as
reasonably practicable, but not later than the Availability Date (as defined below), an earnings statement covering a period of at least twelve (12) months, beginning after the effective date of each Registration Statement, which earnings statement
shall satisfy the provisions of Section 11(a) of the 1933 Act (for the purpose of this subsection 3(k), “Availability Date” means the 45th day following the end of the fourth fiscal quarter that includes the effective date of such
Registration Statement, except that, if such fourth fiscal quarter is the last quarter of the Company’s fiscal year, “Availability Date” means the 90th day after the end of such fourth fiscal quarter). 
  

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 4. Due Diligence Review; Information. The Company shall make available, during normal business
hours, for inspection and review by the Holders, advisors to and representatives of the Holders (who may or may not be affiliated with the Holders), and any underwriter participating in any disposition of Common Stock on behalf of the Holders
pursuant to a Registration Statement or amendments or supplements thereto or any blue sky or other filing, all financial and other records, all filings with the SEC, and all other corporate documents and properties of the Company as may be
reasonably necessary for the purpose of such review, and cause the Company’s officers, directors and employees, within a reasonable time period, to supply all such information reasonably requested by the Holders or any such representative,
advisor or underwriter in connection with such Registration Statement (including, without limitation, in response to all questions and other inquiries reasonably made or submitted by any of them), prior to and from time to time after the filing and
effectiveness of the Registration Statement for the sole purpose of enabling the Holders and such representatives, advisors and underwriters and their respective accountants and attorneys to conduct initial and ongoing due diligence with respect to
the Company and the accuracy of such Registration Statement. 
  
 Notwithstanding
the foregoing, the Company shall not be required to disclose any information to any party that the Company deems in good faith to be a competitor or potential competitor of the Company, and the Company shall not disclose material nonpublic
information to the Holders, or to advisors to or representatives of the Holders, unless prior to disclosure of such information the Company identifies such information as being material nonpublic information and provides the Holders, such advisors
and representatives with the opportunity to accept or refuse to accept such material nonpublic information for review. 
  
 5. Obligations of the Holders. 
  
 (a) Each Holder shall furnish in writing to the Company such information regarding itself, the Registrable Securities held by it and the intended method
of disposition of the Registrable Securities held by it, as shall be reasonably required to effect the registration of such Registrable Securities and shall execute such documents in connection with such registration as the Company may reasonably
request. At least fifteen (15) Business Days prior to the first anticipated filing date of any Registration Statement, the Company shall notify each Holder of the information the Company requires from such Holder if such Holder elects to have any of
the Registrable Securities included in the Registration Statement. A Holder shall provide such information to the Company at least five (5) Business Days prior to the first anticipated filing date of such Registration Statement if such Holder elects
to have any of the Registrable Securities included in the Registration Statement. For purposes of the first sentence of this Section 5(a), the methods of distribution to be specified by the Holders shall include, without limitation, the sale of the
Registrable Securities through (i) options transactions relating to the Registrable Securities, whether such options are listed on an options exchange or otherwise, or (ii) short sales of the Registrable Securities. The Registration Statement shall
also provide that, for purposes of the distribution of the Registrable Securities, the Holders may (i) enter into hedging transactions with broker-dealers or other financial institutions, which may in turn engage in short sales of the Registrable
Securities and deliver the Registrable Securities to close out their short positions or (ii) loan or pledge the Registrable Securities to broker-dealers or other financial institutions, which in turn may sell the Registrable Securities. 

 

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 (b) Each Holder, by its acceptance of the Registrable Securities, agrees to cooperate with the Company
as reasonably requested by the Company in connection with the preparation and filing of a Registration Statement hereunder, unless such Holder has notified the Company in writing of its election to exclude all of its Registrable Securities from such
Registration Statement. 
  
 (c) In the event the Company, at the
request of the Holders, determines to engage the services of an underwriter, such Holder agrees to enter into and perform its obligations under an underwriting agreement, in usual and customary form, including, without limitation, customary
indemnification and contribution obligations, with the managing underwriter of such offering and take such other actions as are reasonably required in order to expedite or facilitate the dispositions of the Registrable Securities. 
  
 (d) Each Holder agrees that, upon receipt of any notice from the Company of
the happening of any event rendering a Registration Statement no longer effective, such Holder will immediately discontinue disposition of Registrable Securities pursuant to the Registration Statement covering such Registrable Securities, until the
Holder’s receipt of copies of the supplemented or amended Prospectus filed with the SEC and declared effective and, if so directed by the Company, the Holder shall deliver to the Company (at the expense of the Company) or destroy (and deliver
to the Company a certificate of destruction) all copies in the Holder’s possession of the Prospectus covering the Registrable Securities current at the time of receipt of such notice. 
  
 (e) No Holder may participate in any third party underwritten registration
hereunder unless it (i) agrees to sell the Registrable Securities on the basis provided in any underwriting arrangements in usual and customary form entered into by the Company, (ii) completes and executes all questionnaires, powers of attorney,
indemnities, underwriting agreements and other documents reasonably required under the terms of such underwriting arrangements, and (iii) agrees to pay its pro rata share of all underwriting discounts and commissions. Notwithstanding the foregoing,
no Holder shall be required to make any representations to such underwriter, other than those with respect to itself and the Registrable Securities owned by it, including its right to sell the Registrable Securities, and any indemnification in favor
of the underwriter by the Holders shall be several and not joint and limited in the case of any Holder, to the net proceeds received by such Holder from the sale of its Registrable Securities. The scope of any such indemnification in favor of an
underwriter shall be limited to the same extent as the indemnity provided in Section 6(b) hereof. 
  
 6. Indemnification. 
  
 (a) Indemnification by the Company. The Company will indemnify and hold harmless each Holder and their respective Affiliates, officers, directors,
members, employees and agents, successors and assigns, against any losses, claims, damages or liabilities, joint or several, to which such Holder, Affiliate, officer, director, member, employee, agent, successor or assign may become subject under
the 1933 Act or otherwise, insofar as such losses, claims, damages or liabilities (or actions in respect thereof) arise out of or are based upon: (i) any untrue statement or alleged untrue statement of any material fact contained in any Registration
Statement, any preliminary prospectus or final prospectus contained therein, or any 
  

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 amendment or supplement thereof; (ii) any blue sky application or other document executed by the Company specifically for
blue sky compliance or based upon written information furnished by the Company filed in any state or other jurisdiction in order to qualify any or all of the Registrable Securities under the securities laws thereof (any such application, document or
information herein called a “Blue Sky Application”); (iii) the omission or alleged omission to state therein a material fact required to be stated therein or necessary to make the statements therein not misleading; (iv) any
violation by the Company, or its directors, officers, employees or agents of any rule or regulation promulgated under the 1933 Act applicable to the Company or its directors, officers, employees or agents and relating to action or inaction required
of the Company or any of them in connection with such registration; or (v) any failure to use its best efforts to register or qualify the Registrable Securities included in any such Registration Statement in any state where the Company or its agents
has affirmatively undertaken or agreed in writing that the Company will undertake such registration or qualification on a Holder’s behalf (the undertaking of any underwriter chosen by the Company being attributed to the Company) and will
reimburse such Holder, and each such officer, director or member and each such controlling person for any legal or other expenses reasonably incurred by them in connection with investigating or defending any such loss, claim, damage, liability or
action; provided, however, that the Company will not be liable in any such case if and to the extent that any such loss, claim, damage or liability arises out of or is based upon an untrue statement or alleged untrue statement or
omission or alleged omission made in conformity with information furnished in writing by such Holder or any such controlling person specifically for use in such Registration Statement or Prospectus; provided, further, however,
that the foregoing indemnity agreement with respect to any Registration Statement or Prospectus shall not inure to the benefit of any Holder or underwriter, or any person controlling such Holder or underwriter, from whom the person asserting any
such losses, claims, damages or liabilities purchased Registrable Securities, if a copy of the Prospectus (as then amended or supplemented if the Company shall have furnished to such Holder or underwriter any amendments or supplements thereto prior
to such purchase) was furnished to such Holder or underwriter by the Company in accordance with Section 3(d) hereof and not sent or given by or on behalf of such Holder or underwriter to such person, if required by law so to have been delivered, at
or prior to the written confirmation of the sale of the Registrable Securities to such person, and if the Prospectus (as to amended or supplemented) would have completely cured the defect giving rise to such loss, claim, damage or liability.

  
 (b) Indemnification by the Holders. In connection with
any Registration Statement pursuant to the terms of this Agreement, each Holder will furnish to the Company in writing such information as the Company reasonably requests concerning such Holder or the proposed manner of such Holder’s
distribution for use in connection with any Registration Statement or Prospectus and agrees, severally but not jointly, to indemnify and hold harmless, to the fullest extent permitted by law, the Company, its Subsidiaries and its and their
respective directors, officers, employees, shareholders and each person who controls the Company (within the meaning of the 1933 Act) against any losses, claims, damages, liabilities and expenses (including reasonable attorney fees) resulting from
any untrue statement of a material fact or any omission of a material fact required to be stated in the Registration Statement or Prospectus or preliminary prospectus or amendment or supplement thereto or necessary to make the statements therein not
misleading, to the extent, but only to the extent that such untrue statement or omission is contained in any information furnished in writing by such 
  

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 Holder to the Company specifically for inclusion in such Registration Statement or Prospectus or amendment or supplement
thereto. In no event shall the liability of a Holder be greater in amount than the aggregate dollar amount of the proceeds (net of all expenses paid by such Holder and the amount of any damages such Holder has otherwise been required to pay by
reason of such untrue statement or omission) received by such Holder upon the sale of the Registrable Securities included in the Registration Statement giving rise to such indemnification obligation. 
  
 (c) Conduct of Indemnification Proceedings. Any person entitled to
indemnification hereunder shall (i) give prompt notice to the indemnifying party of any claim with respect to which it seeks indemnification and (ii) permit such indemnifying party to assume the defense of such claim with counsel reasonably
satisfactory to the indemnified party; provided that any person entitled to indemnification hereunder shall have the right to employ separate counsel and to participate in the defense of such claim, but the fees and expenses of such counsel
shall be at the expense of such person unless (a) the indemnifying party has agreed to pay such fees or expenses, or (b) the indemnifying party shall have failed to assume the defense of such claim and employ counsel reasonably satisfactory to such
person or (c) in the reasonable judgment of any such person, based upon advice of its counsel, a conflict of interest exists between such person and the indemnifying party with respect to such claims (in which case, if the person notifies the
indemnifying party in writing that such person elects to employ separate counsel at the expense of the indemnifying party, the indemnifying party shall not have the right to assume the defense of such claim on behalf of such person); and
provided, further, that the failure of any indemnified party to give notice as provided herein shall not relieve the indemnifying party of its obligations hereunder, except to the extent that such failure to give notice shall actually
and materially adversely affect the indemnifying party in the defense of any such claim or litigation. It is understood that the indemnifying party shall not, in connection with any proceeding in the same jurisdiction, be liable for fees or expenses
of more than one separate firm of attorneys at any time for all such indemnified parties. No indemnifying party will, except with the consent of the indemnified party, consent to entry of any judgment or enter into any settlement that does not
include as an unconditional term thereof the giving by the claimant or plaintiff to such indemnified party of a release from all liability in respect of such claim or litigation. 
  
 (d) Contribution. If for any reason the indemnification provided for in the preceding paragraphs (a) and (b) is
unavailable to an indemnified party or insufficient to hold it completely harmless, other than as expressly specified therein, then the indemnifying party shall contribute to the amount paid or payable by the indemnified party as a result of such
loss, claim, damage or liability in such proportion as is appropriate to reflect the relative fault of the indemnified party and the indemnifying party, as well as any other relevant equitable considerations. No person guilty of fraudulent
misrepresentation within the meaning of Section 11(f) of the 1933 Act shall be entitled to contribution from any person not guilty of such fraudulent misrepresentation. In no event shall the contribution obligation of a Holder be greater in amount
than the aggregate dollar amount of the proceeds (net of all expenses paid by such holder and the amount of any damages such Holder has otherwise been required to pay by reason of such untrue or alleged untrue statement or omission or alleged
omission) received by it upon the sale of the Registrable Securities giving rise to such contribution obligation. 
  

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 (e) Notwithstanding the foregoing, to the extent that the provisions on indemnification and contribution
contained in the underwriting agreement entered into in connection with an underwritten public offering involving the Registrable Securities are in conflict with the foregoing provisions, the provisions in the underwriting agreement shall control,
except with respect to the limitations on liability of the Holders contained in Section 6(b). 
  
 7. Miscellaneous. 
  
 (a)
Amendments and Waivers. This Agreement may be amended only by a writing signed by the then current parties hereto. The Company may take any action herein prohibited, or omit to perform any act herein required to be performed by it, only if
the Company shall have obtained the written consent to such amendment, action or omission to act, of each then current Holder. 
  
 (b) Notices. All notices and other communications provided for or permitted hereunder shall be made as set forth in Section 10.4 of the Purchase
Agreement; provided, however, as the Placement Agent is not a party to the Purchase Agreement, any notice or other communication to the Placement Agent shall be sent to the address for the Placement Agent set forth on the signature
page hereof (which address the Placement Agent may change in accordance with Section 10.4 of the Purchase Agreement). 
  
 (c) Assignments and Transfers by Holders. A Holder may transfer or assign, in whole or from time to time in part, to one or more persons its
rights hereunder in connection with the transfer of Registrable Securities by such Holder to such person, provided, that, such Holder complies with all applicable laws thereto and provides written notice of assignment to the Company
promptly after such assignment is effected. 
  
 (d)
Assignments and Transfers by the Company. This Agreement shall not be assigned by the Company without the prior written consent of each Holder, except that without the prior written consent of the Holders, but after notice duly given, the
Company shall assign its rights and delegate its duties hereunder to any successor-in-interest corporation, and such successor-in-interest shall assume such rights and duties, in the event of a merger or consolidation of the Company with or into
another corporation or the sale of all or substantially all of the Company’s assets. 
  
 (e) Benefits of the Agreement. The terms and conditions of this Agreement shall inure to the benefit of and be binding upon the respective permitted successors and assigns of the parties. Nothing in this
Agreement, express or implied, is intended to confer upon any party other than the parties hereto or their respective successors and assigns any rights, remedies, obligations, or liabilities under or by reason of this Agreement, except as expressly
provided in this Agreement. 
  
 (f) Counterparts; Faxes.
This Agreement may be executed in two or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. This Agreement may also be executed via facsimile, which shall be deemed
an original. 
  

 -11- 

 (g) Titles and Subtitles. The titles and subtitles used in this Agreement are used for
convenience only and are not to be considered in construing or interpreting this Agreement. 
  
 (h) Severability. Any provision of this Agreement that is prohibited or unenforceable in any jurisdiction shall, as to such jurisdiction, be ineffective to the extent of such prohibition or unenforceability
without invalidating the remaining provisions hereof but shall be interpreted as if it were written so as to be enforceable to the maximum extent permitted by applicable law, and any such prohibition or unenforceability in any jurisdiction shall not
invalidate or render unenforceable such provision in any other jurisdiction. To the extent permitted by applicable law, the parties hereby waive any provision of law which renders any provisions hereof prohibited or unenforceable in any respect.

  
 (i) Further Assurances. The parties shall execute and
deliver all such further instruments and documents and take all such other actions as may reasonably be required to carry out the transactions contemplated hereby and to evidence the fulfillment of the agreements herein contained. 
  
 (j) Entire Agreement. This Agreement is intended by the parties as a
final expression of their agreement and intended to be a complete and exclusive statement of the agreement and understanding of the parties hereto in respect of the subject matter contained herein. This Agreement supersedes all prior agreements and
understandings between the parties with respect to such subject matter. 
  
 (k) Governing Law; Consent to Jurisdiction. This Agreement shall be governed by, and construed in accordance with, the internal laws of the State of New York without regard to the choice of law principles
thereof. Each of the parties hereto irrevocably submits to the exclusive jurisdiction of the courts of the State of New York located in New York County and the United States District Court for the Southern District of New York for the purpose of any
suit, action, proceeding or judgment relating to or arising out of this Agreement and the transactions contemplated hereby. Service of process in connection with any such suit, action or proceeding may be served on each party hereto anywhere in the
world by the same methods as are specified for the giving of notices under this Agreement. Each of the parties hereto irrevocably consents to the jurisdiction of any such court in any such suit, action or proceeding and to the laying of venue in
such court. Each party hereto irrevocably waives any objection to the laying of venue of any such suit, action or proceeding brought in such courts and irrevocably waives any claim that any such suit, action or proceeding brought in any such court
has been brought in an inconvenient forum. 
  
 [Signature Pages
Follow] 
  

 -12- 

 [Company Signature Page] 
  
 IN WITNESS WHEREOF, the Company has executed this Registration Rights Agreement or caused its duly authorized officers to
execute this Registration Rights Agreement as of the date first above written. 
  

					
	 The Company:
	 	 INCARA PHARMACEUTICALS CORPORATION

			
	 	 	 By:
	 	  

	 	 	 Name:

	 	 	 Title:

		
	 The Placement Agent:
	 	 SCO SECURITIES, LLC

			
	 	 	 By:
	 	  

	 	 	 Name:

	 	 	 Title:

  

 -13- 

 [Holder Signature Page] 
  
 IN WITNESS WHEREOF, the undersigned has executed this Registration Rights Agreement or caused its duly authorized officers
to execute this Registration Rights Agreement as of the date first above written. 
  

					
	 IF AN INDIVIDUAL:
	 	 IF A CORPORATION, PARTNERSHIP,

	 	 	 TRUST, ESTATE OR OTHER ENTITY:

	  

	 	 
	 (Signature)
	 	  
  

	 	 	 Print name of entity

	  

	 	 	 	 
	 (Printed Name)
	 	 By:
	 	  
  

	 	 	 Name:
	 	  
  

	 	 	 Title:
	 	  
  

		
	 Address:
	 	 Address:

	  
  

	 	  
  

	  

	 	  

	  

	 	  

  

 -14-Amendment

 Exhibit 10.104 
  
 AGREEMENT 
 AND 
 AMENDMENT NO. 1 
 TO THE 
 DEBENTURE AND WARRANT PURCHASE AGREEMENT 
  
 This AGREEMENT AND AMENDMENT NO. 1 TO THE DEBENTURE AND WARRANT PURCHASE
AGREEMENT (this “Agreement”), is made as of April 19, 2004, by and among Incara Pharmaceuticals Corporation (f/k/a Incara, Inc.), a Delaware corporation (the “Company”) and successor-by-merger to
Incara Pharmaceuticals Corporation (the “Former Parent”), and Goodnow Capital, L.L.C., a Delaware limited liability company and successor-by-merger to Goodnow Capital, Inc. (the “Investor”).

  
 RECITALS 
  
 A. The Company is proposing to enter into a Purchase Agreement, of even date
herewith, with the investors that are signatory thereto (the “April Purchase Agreement”), pursuant to which the Company will issue and sell up to $10,260,000 of its Common Stock, together with warrants to acquire up to
16,416,000 shares of its Common Stock (the “Financing”). 
  
 B. Pursuant to a corporate reorganization completed on November 20, 2003, the Former Parent merged with and into the Company, its wholly-owned subsidiary. 
  
 C. The Company, the Former Parent and the Investor had entered into a certain Debenture and Warrant Purchase Agreement,
dated as of September 16, 2003 (the “September Purchase Agreement”) pursuant to which the Company issued to the Investor (i) a Secured Convertible Debenture, dated January 9, 2004, in the principal amount of $5,000,000, the
proceeds of which are to be funded over time in accordance with the September Purchase Agreement and the Debenture (the “Debenture”), and (ii) various Warrants to purchase shares of common stock of the Company, upon the terms
and conditions set forth therein, which Warrants have now expired unexercised. 
  
 D. Subject to certain conditions specified in the September Purchase Agreement and the terms of the Debenture, the Company may request draws upon satisfaction of such conditions and compliance with such terms,
including without limitation, the Company’s compliance with the use of proceeds requirements set forth in an approved budget and/or plan. 
  
 E. The Investor has agreed to waive the conditions to making any further draws, and to fund the balance of the principal under the Debenture and thereupon
fully convert the Debenture in accordance with its terms, all concurrently with the Financing. 

 F. The Company has requested the Investor’s consent to and approval of, and the Investor has, to the
extent provided herein, agreed to consent to and approve of, the Financing in accordance with the terms of the September Purchase Agreement. 
  
 G. In consideration of the Investor’s aforesaid agreements, waiver and consent, the Company has agreed to amend the September Purchase Agreement to
continue the limitation on the Company’s expenditures in a manner similar to the limitation presently contained in the Debenture, all as hereinafter set forth. 
  
 Capitalized terms used but not otherwise defined in this Agreement shall have the meanings ascribed to such terms in the
September Purchase Agreement, unless the context requires otherwise. 
  
 NOW, THEREFORE, IN CONSIDERATION of the mutual promises made herein and for other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the parties hereto agree as follows: 
  
 SECTION 1 
  
 AGREEMENT 
  
 1.1 The Financing. 
  
 The Investor hereby consents to, and this Agreement constitutes the
Investor’s approval pursuant to Sections 8.6(a), 8.9(o) and 8.9(q) of the September Purchase Agreement, of the Financing in accordance with the terms of the April Purchase Agreement; provided, however, the Financing shall be
limited to, and the Company shall not have the right to issue and sell more than, 31,040,000 shares of Common Stock (at $0.25 per share) and warrants to acquire no more than 12,416,000 shares of Common Stock, if Xmark Asset Management, LLC does not
obtain, by voting trust or in any other manner satisfactory to it, sole voting power with respect to all of the shares of Common Stock to be acquired in the Financing by Great Point Partners (and its Affiliates). For the Financing and only for the
Financing, in which shares of the Common Stock are to be sold for $0.25 per share, the Investor hereby specifically waives the Company’s compliance with the restriction set forth in clause (ii) of the penultimate sentence in Section 8.6(a) of
the September Purchase Agreement (that shares of Common Stock must be sold at a per share price in excess of $0.30 per share), provided, that, the Financing is consummated in accordance with the April Purchase Agreement;
provided, further, that, the proceeds from the sale of the Common Stock and number of shares of Common Stock sold in the Financing shall reduce the amounts in clauses (i) and (iii), respectively, of the penultimate sentence in
Section 8.6(a) of the September Purchase Agreement. 
  
 1.2 Conversion of Debenture. 
  
 (a) The Company shall
have caused to be delivered to the Investor the certificate specified in Section 9(j) of the September Purchase Agreement, executed on behalf of 

 the Company by its Chief Executive Officer or its Chief Financial Officer, and the Investor shall have advanced to the
Company, by wire transfer, the balance of the principal that may be advanced under the Debenture, in the amount of $2,500,000. Following the Company’s and the Investor’s compliance with the preceding sentence, this Agreement shall
constitute a notice of conversion under Section 6(b) of the Debenture, in which the Investor elects to convert, effective as of the date hereof, the entire principal balance then outstanding under the Debenture, together with all accrued and
unpaid interest thereon (after giving effect to the aforesaid advance), into 50,468,750 shares of Common Stock. The Company shall cause a certificate evidencing such shares of Common Stock to be delivered to the Investor in accordance with Section
6(b) of the Debenture. 
  
 (b) Upon conversion of the Debenture
and issuance to the Investor of the shares of Common Stock thereunder, the Company shall be authorized to file any and all UCC-3 termination statements with respect to the security interests held by the Investor as security for the Debenture.

  
 (c) For purposes of emphasis and clarification, the Company
hereby acknowledges and agrees that: (i) each of the covenants set forth in Section 8.7 of the September Purchase Agreement remains in place and in effect, in accordance with its terms; and (ii) each of the covenants set forth in Section 8.9 of the
September Purchase Agreement, except as modified below, remains in place and in effect, in accordance with its terms. 
  
 (d) The Company hereby agrees to use its best efforts to obtain amendments (in form and substance reasonably satisfactory to the Investor) to the license
agreements described in Section 4.13 of the Aeolus Security Agreement (as amended and restated by the Amended Aeolus Security Agreement) to clarify that the Company will own the intellectual property licensed thereunder upon any termination or
expiration of such agreements. 
  
 (e) Within 10 days after the
closing of the transactions contemplated by the April Purchase Agreement, the Company shall file this Agreement as an exhibit to a Current Report on Form 8-K with the Securities and Exchange Commission. 
  
 SECTION 2 
  
 AMENDMENT 
  
 Section 8.9 (p) of the September Purchase Agreement is hereby deleted and
replaced in its entirety with the following: 
  
 (p) make any
single expenditure, or series of related expenditures, in excess of $25,000, or incur any obligations to make any such expenditure(s), except for those expenditures and obligations (1) pursuant to the SBIR grant from the U.S. Small Business
Administration, (2) specified in a budget approved in writing in advance by the Company and the Investor, and (3) directly relating to the 

 development of AEOL-10150 for the treatment of Amyotrophic Lateral Sclerosis, provided,
that, nothing in this Section 8.9(p) shall permit any expenditure or obligation that is otherwise not permitted under this Agreement or any other Transaction Document; or 
  
 SECTION 3 
  
 MISCELLANEOUS 
  
 3.1 Governing Law. This Agreement and the September Purchase Agreement, and all matters arising directly or indirectly hereunder or
thereunder, shall be governed by, and construed in accordance with, the internal laws of the State of New York, without reference to the choice of law principles thereof. 
  
 3.2 Counterparts. This Agreement may be executed in counterparts, each of which shall be deemed an original
agreement, but all of which together shall constitute one and the same instrument. 
  
 3.3 Titles and Headings. The titles and headings in this Agreement are for reference purposes only, and shall not in any way affect the meaning or interpretation of this Agreement. 
  
 3.4 Entire Agreement. This Agreement and the September Purchase
Agreement constitute the entire agreement between the parties with respect to the matters covered hereby and thereby and supersede all previous written, oral or implied understandings between them with respect to such matters. The September Purchase
Agreement shall remain in full force and effect, except to the extent expressly modified herein, and to the extent of any inconsistency between the terms of the September Purchase Agreement and this Agreement, this Agreement shall control.

  
 3.5 Waiver. Any of the terms or conditions of this
Agreement may be waived at any time by the party or parties entitled to the benefit thereof, but only by a writing signed by the party or parties waiving such terms or conditions. 
  
 3.6 No Strict Construction. The Company and the Investor each acknowledge that this Agreement has been
prepared jointly by the parties hereto, and shall not be strictly construed against either party. 
  
 3.7 Conflicts. Except as expressly modified herein, the September Purchase Agreement shall remain in full force and effect, and to the
extent of any conflicts between this Agreement and the September Purchase Agreement, this Agreement shall control. 
  
 3.8 References. All references to the September Purchase Agreement in any other agreement between the Company and the Investor shall be deemed to
constitute references to the September Purchase Agreement as amended by this Agreement, notwithstanding any failure to reference this Agreement. 

 3.9 Further Assurance. Subject to the terms and conditions provided herein and in the September
Purchase Agreement, each of the parties hereto shall use all reasonable efforts to take, or cause to be taken, all action, and to do, or cause to be done, all things reasonably necessary, proper or advisable under applicable laws and regulations to
consummate and make effective the transactions contemplated by this Agreement. 
  
 IN WITNESS WHEREOF, the parties hereto have caused their duly authorized officers to execute and deliver this Agreement as of the date first above written. 
  

					
	 The Company:
	 	 INCARA PHARMACEUTICALS CORPORATION

			
	 	 	 By:
	 	  

	 	 	 Name:

	 	 	 Title:

		
	 The Investor:
	 	 GOODNOW CAPITAL, L.L.C.

			
	 	 	 By:
	 	  

	 	 	 Name:

	 	 	 Title:

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