Document:

adc_Ex10_1

		
			Exhibit 10.1
		

		
			 
		

		
			PERFORMANCE UNIT AWARD NOTICE

Agree Realty Corporation

________, 20___
		

		
			THIS PERFORMANCE UNIT AWARD NOTICE, dated as of _________, 20__, sets forth the terms of a grant of performance units by Agree Realty Corporation, a Maryland corporation (the “Company”), to the Grantee named below.
		

		
			WHEREAS, the Company has adopted the Agree Realty Corporation 2014 Omnibus Incentive Plan (the “Plan”) in order to enhance the ability of the Company to attract and retain highly qualified employees and to motivate those employees to improve the business results of the Company; and
		

		
			WHEREAS, the Committee has determined to grant to the Grantee an award of Performance Units as provided herein to encourage the Grantee’s efforts toward the continuing success of the Company.
		

		
			The Company grants to the Grantee an award on the following terms and subject to the following conditions:
		

			
	
			
				 1.
			

			
	
			
			Grant by the Company.  The Company grants to the Grantee a Performance Award for Performance Units (the “Award”).  Subject to the terms and conditions hereof, payment with respect to vested Awards shall be made entirely in the form of shares of Restricted Stock of the Company.  This Award shall be construed in accordance and consistent with, and subject to, the provisions of the Plan (the provisions of which are hereby incorporated by reference) and, except as otherwise expressly set forth herein, the capitalized terms used in this Award shall have the same definitions as set forth in the Plan.

			
					
						AWARD SUMMARY

				
	
					
						 

				
	
					
						Name of Grantee:

					
					
						_________________

				
	
					
						Target Number of Performance Units:

					
					
						 

					
						_________________

				
	
					
						Grant Date:

					
					
						_____________, 20__

				
	
					
						Performance Period:

					
					
						December 31, 20__ through December 31, 20__

				

		
			 
		

			
	
			
				 2.
			

			
	
			
			Performance Objective.  Performance Units shall be earned based on the achievement of (i) as to 50% of the Award, relative annualized Total Shareholder Return compared to the Total Shareholder Return during the Performance Period of the constituent companies comprising the MSCI US REIT index (the “MSCI Peer Group”) (where the Company is considered part of the peer group) and (ii) as to 50% of the Award, relative annualized Total Shareholder Return compared to the Total Shareholder Return of designated peer companies over the Performance Period as provided on the attached Appendix A (the “TSR Peer Group”) (where the Company is considered to be part of the peer set) with the result expressed as a percentile.  “Performance Period” shall be defined as the period from December 31, 20__ through December 31, 20__.  “Total Shareholder Return” shall be defined as the increase in value of a fixed amount invested in the common shares of an entity, taking into account both stock price appreciation and dividends or other distributions, during the Performance Period (dividends are calculated as if they are reinvested in a company’s stock as of the ex-dividend date based on such date’s closing stock price).  In determining the value of shares at the beginning and end of the Performance Period, the Committee shall use the average closing price for the twenty (20) trading days ending on the beginning and end of the Performance Period.  The applicable MSCI and TSR Peer Groups for the Performance Period shall be the group of publically traded REITs listed on the attached Appendix A.

		
			

		 

 

		

			
	
			
				 3.
			

			
	
			
			Peer Group Adjustments.  Any company in the MSCI Peer Group or the TSR Peer Group that files for bankruptcy protection shall be placed at the bottom of the applicable Peer Group.  Any company in the MSCI Peer Group or the TSR Peer Group that is acquired and is no longer separately trading will be excluded from the applicable Peer Group, and the size of the applicable Peer Group will be reduced by one.  No changes to the MSCI Peer Group or the TSR Peer Group will be made as a result of an acquisition or divestiture by a company in the applicable Peer Group of a portion of its business, as such events are generally considered to be part of the ordinary course of business; however, in the instance where a peer company has entered an agreement to be acquired and such transaction has not yet been consummated at the end of the performance period, such peer company will be excluded from results as if it had already been acquired.

			
	
			
				 4.
			

			
	
			
			Determination of Award and Notice.  As soon as possible after the end of the Performance Period, but in no event later than March 15 of the year following the end of the Performance Period, the Compensation Committee of the Board of Directors (the “Committee”) will certify in writing whether and to what extent the performance measures have been achieved for the Performance Period and determine the number of shares of Restricted Stock, if any, to be issued to the Grantee in accordance with the matrix set forth in Appendix A; provided, that, if the Committee certifies that the performance measures have been met, the Committee may, in its sole discretion, reduce the number of shares to be issued to the Grantee with respect to the Award.  The date of the Committee’s certification pursuant to this Section 4 shall hereinafter be referred to as the “Certification Date.” The Company will notify the Grantee of the Committee’s certification promptly following the Certification Date.  Any Restricted Stock earned shall vest one-third on _________, 20__, one-third on __________, 20__ and one-third on ___________, 20__, in accordance with the Company’s standard form of restricted stock award agreement.

			
	
			
				 5.
			

			
	
			
			Forfeiture of Award Prior to Vesting Date.  Except as provided by the Committee, the Grantee will not be entitled to any issuance of shares with respect to the Award if the Grantee is not, for any reason, employed by the Company or an Affiliate of the Company on the Certification Date. 

			
	
			
				 6.
			

			
	
			
			Change in Control.  In the event of a Change in Control where such Performance Award is not assumed or substituted by the successor/acquirer company, such Performance Award shall vest at the greater of target or actual performance through the date of the Change in Control.  In the event such Performance Award is assumed or substituted by the successor/acquirer company, such Performance Award shall be immediately converted into Restricted Stock Units, the number of which shall be determined at the greater of target or actual performance through the date of the Change in Control (or as near to this date as practicable).  Such Restricted Stock Units or substitute award shall maintain the original vesting date of such underlying Performance Award.  Notwithstanding any other provision of this Agreement to the contrary, in the event that the Grantee is terminated without Cause or terminates with Good Reason (as defined below) within twenty four (24) months following the Change in Control, such Restricted Stock Units or substitute award shall become fully vested and all applicable restrictions shall immediately lapse.

		
			For purposes of this Award, “Good Reason” shall mean, without Grantee’s consent, (i) a material and adverse change in Grantee’s title or (ii) a material reduction in Grantee’s base salary; provided that, prior to terminating employment for Good Reason, Grantee must provide written notice to the Company within thirty (30) days after the initial existence of the condition constituting Good Reason and provide the Company a period of thirty (30) days to remedy such condition; and provided further that if the Company fails to cure such condition, the Grantee must resign Grantee’s employment within thirty (30) days following the Company’s failure to remedy the condition constituting Good Reason.
		

			
	
			
				 7.
			

			
	
			
			No Rights as a Shareholder.  Prior to any issuance of shares, the Grantee shall not at any time have any rights as a shareholder with respect to any Award.  No dividends (or dividend equivalents) will be paid on any unearned Performance Units.  Dividends on earned Performance Units shall accrue from the Grant Date until the Certification Date and shall be paid on ____________, 20__ [the date of the vesting of the 

		 

 

	first installment of restricted stock to vest], to the extent of Performance Units that are earned and result in a share issuance.

			
	
			
				 8.
			

			
	
			
			No Right to Continued Employment.  Nothing in this Award or the Plan shall interfere with or limit in any way the right of the Company to terminate the Grantee’s employment, nor confer upon the Grantee any right to continuance of employment by the Company or any Affiliate.

			
	
			
				 9.
			

			
	
			
			Construction.  This Award is made and granted pursuant to the Plan and is in all respects limited by and subject to the terms of the Plan.  In the event of any conflict between the provisions of this Award and the terms of the Plan, the terms of the Plan shall be controlling.  To the extent not prohibited by applicable law or the Plan, the terms of any employment, severance or change in control agreement between the Grantee and the Company shall supersede the terms and definitions under the 2014 Omnibus Incentive Plan and this Agreement with respect to the Performance Units awarded hereunder.  All decisions of the Committee with respect to any question or issue arising under the Plan or this Award shall be conclusive and binding on all persons having an interest in the Award.

			
	
			
				 10.
			

			
	
			
			Resolution of Disputes.  Any dispute or disagreement which may arise under, or as a result of, or in any way relate to, the interpretation, construction or application of this Award shall be determined by the Committee.  Any determination made hereunder shall be final, binding and conclusive on the Grantee, the Grantee’s heirs, executors, administrators and successors, and the Company and its Affiliates for all purposes.

			
	
			
				 11.
			

			
	
			
			Entire Statement of Award.  This Award and the terms and conditions of the Plan constitute the entire understanding between the Grantee and the Company and its Affiliates, and supersede all other agreements, whether written or oral, with respect to the Award.

			
	
			
				 12.
			

			
	
			
			Successors and Assigns.  This Award shall be binding upon and inure to the benefit of the parties hereto and the successors and assigns of the Company and the Grantee’s heirs and representatives of his estate.

			
	
			
				 13.
			

			
	
			
			Headings.  The headings of this Award are inserted for convenience only and do not constitute a part of this Award.

			
	
			
				 14.
			

			
	
			
			Other Payments or Awards.  Nothing contained in this Award shall be deemed in any way to limit or restrict the Company from making any award or payment to the Grantee under any other plan, arrangement or understanding, whether now existing or hereafter in effect.

			
	
			
				 15.
			

			
	
			
			Effect on Other Benefits.  In no event will the value, at any time, of the Performance Units or any other payment or right to payment under this Award be included as compensation or earnings for purposes of any other compensation, retirement, or benefit plan offered to employees of, or other service providers to, the Company unless otherwise specifically provided for in such plan. 

			
	
			
				 16.
			

			
	
			
			Notices.  Any notice to be given to the Company hereunder shall be in writing and shall be addressed to the Company at 70 East Long Lake Road, Bloomfield Hills, MI 48304, attention: [Chief Financial Officer], or at such other address as the Company may hereafter designate to the Grantee by written notice as provided herein.  Any notice to be given to the Grantee hereunder shall be addressed to the Grantee at the address set forth beneath the Grantee’s signature hereto, or at such other address as he may hereafter designate to the Company by written notice as provided herein.  Notices hereunder shall be deemed to have been duly given:  (i) when personally delivered, (ii) three (3) days after having been mailed by registered or certified mail to the party entitled to receive the same, (iii) one (1) day after having been mailed by a nationally recognized overnight courier or (iv) on the date sent by electronic mail transmission.

		
			

		 

 

		

			
	
			
				 17.
			

			
	
			
			Transfer of Personal Data.  The Grantee authorizes, agrees and unambiguously consents to the transmission by the Company of any personal data information related to the Performance Units awarded under this Award for legitimate business purposes (including, without limitation, the administration of the Plan).  This authorization and consent is freely given by the Grantee.

			
	
			
				 18.
			

			
	
			
			Governing Law.  This Award shall be deemed to be a contract made under the laws of the State of Maryland and for all purposes shall be governed by, construed and enforced in accordance with the internal laws of said State, without giving effect to any choice of law or conflict of law provisions or rules that would cause the application of the laws of any jurisdiction other than the State of Maryland.

			
	
			
				 19.
			

			
	
			
			Compliance with Laws.  The issuance of any shares pursuant to this Award shall be subject to, and shall comply with, any applicable requirements of any foreign and U.S. federal and state securities laws, rules and regulations (including, without limitation, the provisions of the Securities Act, the Exchange Act and in each case any respective rules and regulations promulgated thereunder) and any other law or regulation applicable thereto.  The Company shall not be obligated to issue any shares pursuant to this Award if any such issuance would violate any such requirements.

			
	
			
				 20.
			

			
	
			
			Code Section 409A.  The Award is intended to either be exempt from or to comply with Code Section 409A and shall be interpreted and administered consistent with that intent, provided,  however, that the Company makes no representation regarding the status of the Award under Code Section 409A and the Company shall not be liable for any additional tax, interest or penalty that may be imposed upon the Grantee, or other damage that may be suffered by the Grantee, as a result of the Award being subject to and not in compliance with Code Section 409A.  Each payment required to be made hereunder shall be treated as a separate and distinct payment for purposes of Code Section 409A.  If (i) an amount owing to the Grantee hereunder constitutes nonqualified deferred compensation subject to Code Section 409A, (ii) the amount is considered to be payable to the Grantee as a result of the Grantee’s “separation from service” with the Company and its Affiliates for purposes and within the meaning of Code Section 409A, and (iii) the Grantee is at the time of separation from service a “specified employee” of the Company and its Affiliates, then (notwithstanding any other provision hereof) the amount shall not be paid to the Grantee any earlier than the time when such amount may be paid to the Grantee without the Grantee being subject to liability for additional tax on such amount under Code Section 409A.

			
	
			
				 21.
			

			
	
			
			Tax Withholding Obligation.  If upon the Certification Date, any vesting date or other applicable date there shall be payable by the Company or an affiliate of the Company any statutory income and/or employment tax withholding, in the Company's discretion, then unless provided otherwise by the Company, such tax withholding obligations, if any, will be satisfied by the Company withholding a number of shares of Common Stock that would otherwise be vested under the Award in an amount that the Company determines has a fair market value sufficient to meet such tax withholding obligations, up to the maximum statutory withholding requirement.  In the Company's discretion, it may require or permit reimbursement or payment of such tax withholding obligations by wire transfer, certified check, additional payroll withholding or other means acceptable to the Company and upon such terms and conditions as the Company may prescribe.  The Company may also permit the Grantee to tender shares to the Company subsequent to receipt of such shares in respect of an Award.  The Company is permitted to defer issuance of shares until reimbursement or payment by the Grantee to the Company or an affiliate of the Company of the amount of any such tax.

		
			The Grantee is ultimately liable and responsible for all taxes owed by such Grantee in connection with the Award, regardless of any action the Company takes with respect to any tax withholding obligations that arise in connection with the Award.  The Company makes no representation or undertaking regarding the treatment of any tax withholding in connection with the grant or issuance of the Performance Units or the subsequent sale of any of the shares underlying the Performance Units.  The Company does not commit 

		 

 

and is under no obligation to structure the Award program to reduce or eliminate the Participant's tax liability.
		

		
			 
		

		
			IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of ________________________, _____.
		

		
			AGREE REALTY CORPORATION
		

		
			 
		

		
			By:______________________________________
		

		
			Joey Agree
		

		
			Title:President and Chief Executive Officer
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			Grantee:
		

		
			 
		

		
			Address:
		

		
			 
		

		
			 
		

		
			Email:
		

		
			 
		

		
			 
		

		
			

		

		
			
		

		
			

		 

 

		

		
			APPENDIX A
		

		
			 
		

		
			Custom Peer Group
		

		
			 
		

			
					
						 

					
					
						EPR Properties

					
					
						 

				
	
					
						 

					
					
						 Four Corners Property Trust, Inc.

					
					
						 

				
	
					
						 

					
					
						 Getty Realty Corp

					
					
						 

				
	
					
						 

					
					
						 Lexington Realty Trust

					
					
						 

				
	
					
						 

					
					
						 National Retail Properties, Inc.

					
					
						 

				
	
					
						 

					
					
						 Realty Income Corporation 

					
					
						 

				
	
					
						 

					
					
						 Spirit Realty Capital, Inc.

					
					
						 

				
	
					
						 

					
					
						 STORE Capital Corporation

					
					
						 

				
	
					
						 

					
					
						 VEREIT, Inc.

					
					
						 

				
	
					
						 

					
					
						 W.P. Carey Inc.

					
					
						 

				
	
					
						 

					
					
						 

					
					
						 

				

		
			 
		

		
			MSCI US REIT Index (as of ________, 20___)
		

			
					
						 

				
	
					
						SECURITY NAME

				
	
					
						SIMON PROPERTY GROUP

				
	
					
						PROLOGIS

				
	
					
						PUBLIC STORAGE

				
	
					
						EQUINIX

				
	
					
						WELLTOWER INC

				
	
					
						EQUITY RESIDENTIAL

				
	
					
						AVALONBAY COMMUNITIES

				
	
					
						DIGITAL REALTY TRUST

				
	
					
						VENTAS

				
	
					
						BOSTON PROPERTIES

				
	
					
						REALTY INCOME CORP

				
	
					
						ESSEX PROPERTY TRUST

				
	
					
						HOST HOTELS & RESORTS

				
	
					
						HCP

				
	
					
						ALEXANDRIA REAL ESTATE

				
	
					
						VORNADO REALTY TRUST

				
	
					
						EXTRA SPACE STORAGE

				
	
					
						MID-AMERICA APARTMENT

				
	
					
						UDR

				
	
					
						WP CAREY

				
	
					
						DUKE REALTY CORP

				
	
					
						FEDERAL REALTY INV TRUST

				
	
					
						REGENCY CENTERS CORP

				
	
					
						IRON MOUNTAIN

				
	
					
						CAMDEN PROPERTY TRUST

				
	
					
						EQUITY LIFESTYLE PPTYS

				
	
					
						SUN COMMUNITIES

				
	
					
						SL GREEN REALTY CORP

				
	
					
						VICI PROPERTIES

				
	
					
						NATIONAL RETAIL PPTYS

				

		 

 

	
					
						

					
						OMEGA HEALTHCARE INVESTO

				
	
					
						VEREIT INC

				
	
					
						APARTMENT INV & MGMT

				
	
					
						KILROY REALTY CORP

				
	
					
						GAMING & LEISURE PPTYS

				
	
					
						KIMCO REALTY CORP

				
	
					
						LIBERTY PROPERTY TRUST

				
	
					
						INVITATION HOMES

				
	
					
						MEDICAL PROPERTIES TRUST

				
	
					
						PARK HOTELS & RESORTS

				
	
					
						DOUGLAS EMMETT

				
	
					
						AMERICAN CAMPUS CMNTY

				
	
					
						HEALTHCARE TRUST OF AMER

				
	
					
						CUBESMART

					
						FOREST CITY REALTY TRU A

				
	
					
						CYRUSONE

				
	
					
						AMERICAN HOMES 4 RENT A

				
	
					
						STORE CAPITAL

				
	
					
						MACERICH CO

				
	
					
						EPR PROPERTIES

				
	
					
						BRIXMOR PROPERTY GROUP

				
	
					
						HUDSON PACIFIC PPTYS

				
	
					
						PEBBLEBROOK HOTEL TRUST

				
	
					
						JBG SMITH PROPERTIES

				
	
					
						LIFE STORAGE

				
	
					
						HIGHWOODS PROPERTIES

				
	
					
						HOSPITALITY PROPERTIES

				
	
					
						FIRST INDUSTRIAL REALTY

				
	
					
						HEALTHCARE REALTY TRUST

				
	
					
						EQUITY COMMONWEALTH

				
	
					
						EASTGROUP PROPERTIES

				
	
					
						RLJ LODGING TRUST

				
	
					
						COUSINS PROPERTIES

				
	
					
						WEINGARTEN REALTY

				
	
					
						APPLE HOSPITALITY REIT

				
	
					
						SUNSTONE HOTEL

				
	
					
						RYMAN HOSPITALITY PROP

				
	
					
						SABRA HEALTH CARE REIT

				
	
					
						CORESITE REALTY CORP

				
	
					
						NATL HEALTH INVESTORS

				
	
					
						SENIOR HOUSING PPTYS

				
	
					
						SPIRIT REALTY (NEW)

				
	
					
						PHYSICIANS REALTY TRUST

				
	
					
						TAUBMAN CENTERS

				
	
					
						PARAMOUNT GROUP

				
	
					
						REXFORD INDL REALTY

				
	
					
						PS BUSINESS PARKS

				
	
					
						COLONY CAPITAL A

				
	
					
						GEO GROUP

				

		 

 

	
					
						

					
						BROOKFIELD PPTY REIT A

				
	
					
						STAG INDUSTRIAL

				
	
					
						RETAIL PROP OF AME A

				
	
					
						CORECIVIC

				
	
					
						AMERICOLD REALTY

				
	
					
						BRANDYWINE REALTY TRUST

				
	
					
						CORPORATE OFFICE PPTYS

				
	
					
						COLUMBIA PROPERTY TRUST

				
	
					
						PIEDMONT OFF RLTY TRU A

				
	
					
						ACADIA REALTY TRUST

				
	
					
						XENIA HOTELS AND RESORTS

				
	
					
						EMPIRE STATE REALTY A

				
	
					
						TERRENO REALTY CORP

				
	
					
						TANGER FACTORY OUTLET

				
	
					
						URBAN EDGE PROPERTIES

				
	
					
						DIAMONDROCK HOSPITALITY

				
	
					
						WASHINGTON REAL ESTATE

				
	
					
						QTS REALTY TRUST A

				
	
					
						MGM GROWTH PROPERTIES A

				
	
					
						RETAIL OPPORTUNITY INV

				
	
					
						MACK-CALI REALTY CORP

				
	
					
						SITE CENTERS CORP

				
	
					
						LEXINGTON REALTY TRUST

				
	
					
						AGREE REALTY CORP

				
	
					
						FOUR CORNERS PPTY TRUST

				
	
					
						LTC PROPERTIES

				
	
					
						CHESAPEAKE LODGING TRUST

					
						SELECT INCOME REIT

				
	
					
						CARETRUST REIT

				
	
					
						NATIONAL STORAGE

				
	
					
						GLOBAL NET LEASE

				
	
					
						ALEXANDER & BALDWIN INC

				
	
					
						AMERICAN ASSETS TRUST

				
	
					
						KITE REALTY GRP TRUST

				
	
					
						SERITAGE GROWTH PPTYS A

				
	
					
						HANNON ARMSTRONG

				
	
					
						TIER REIT

				
	
					
						MONMOUTH REIT A

				
	
					
						SUMMIT HOTEL PROPERTIES

				
	
					
						WASHINGTON PRIME GROUP

				
	
					
						RPT REALTY

				
	
					
						EASTERLY GOVERNMENT PPTY

				
	
					
						GETTY REALTY CORP

				
	
					
						UNIVERSAL HEALTH REALTY

				
	
					
						CHATHAM LODGING TRUST

				
	
					
						INDEPENDENCE REALTY TRUS

					
						GOVERNMENT PPTYS INCOME

				
	
					
						FRANKLIN STREET PPTYS

				
	
					
						ARMADA HOFFLER PROP

				

		 

 

	
					
						

					
						NORTHSTAR REALTY EUROPE

				
	
					
						AMERICAN FINANCE TRUST A

				
	
					
						SAUL CENTERS

				
	
					
						ISTAR

				
	
					
						HERSHA HOSPITALITY TRUST

				
	
					
						ALEXANDERS

				
	
					
						NEXPOINT RESIDENTIAL

				
	
					
						INVESTORS REAL ESTATE

				
	
					
						URSTADT BIDDLE PPTYS A

				
	
					
						PREFERRED APT CMNTY

				
	
					
						COREPOINT LODGING

				
	
					
						PENNSYLVANIA REIT

				
	
					
						COMMUNITY HEALTHCARE

				
	
					
						GLADSTONE COMM CORP

				
	
					
						WHITESTONE REIT

				
	
					
						INDUSTRIAL LOGIS PPTYS

				
	
					
						ASHFORD HOSPITALITY TRST

				
	
					
						FRONT YARD RESIDENTIAL

				
	
					
						CBL & ASSOCIATES PPTYS

				
	
					
						UMH PROPERTIES

				
	
					
						NEW SENIOR INV GRP

				
	
					
						RETAIL VALUE

				
	
					
						SPIRIT MTA REIT

				
	
					
						ONE LIBERTY PROPERTIES

				
	
					
						CEDAR REALTY TRUST

				
	
					
						BRAEMAR HOTELS & RESORTS

				

		
			 
		

		
			Payout level for each portion of the Award
		

		
			 
		

			
					
						Level

					
					
						 

					
					
						Comparative Total 
Shareholder Return 
Percentile

					
					
						 

					
					
						Percentage of Target 
Number of Performance 
Units

				
	
					
						Threshold

					
					
						 

					
					
						__th

					
					
						 

					
					
						__%

				
	
					
						Target

					
					
						 

					
					
						__th

					
					
						 

					
					
						__%

				
	
					
						Maximum

					
					
						 

					
					
						__th

					
					
						 

					
					
						__%

				

		
			 
		

		
			There will be a linear increase in payout between the performance levels if Threshold performance is achieved; no payout shall occur below __th percentile performance.EX-10.15

 Exhibit 10.15 

Certain identified information has been excluded from the exhibit because it is both (i) not material and (ii) would likely cause competitive
harm to the Company, if publicly disclosed. Double asterisks denote omissions. 
 EXCLUSIVE LICENSE AGREEMENT 

BY AND BETWEEN 
 TREVI
THERAPEUTICS, INC. 
 AND 

PENWEST PHARMACEUTICALS CO. 

 TABLE OF CONTENTS 

 

							
	 	 	 	  	Page	 
		
	 ARTICLE I DEFINITIONS
	  	 	1	 
		
	 ARTICLE II LICENSE GRANT AND PENWEST OPTION
	  	 	8	 
			
	 2.1
	 	License Grant	  	 	8	 
			
	 2.2
	 	Sublicenses	  	 	8	 
			
	 2.3
	 	Responsibility; Decision-making	  	 	8	 
			
	 2.4
	 	Penwest Option to Negotiate	  	 	9	 
			
	 2.5
	 	Trevi License Grant	  	 	9	 
		
	 ARTICLE III TECHNOLOGY TRANSFER AND TRANSITION ACTIVITIES
	  	 	9	 
			
	 3.1
	 	Know-how Transfer	  	 	9	 
			
	 3.2
	 	Regulatory Transition	  	 	10	 
			
	 3.3
	 	Supply of Material/Technology Transfer	  	 	10	 
			
	 3.4
	 	Transfer of TIMERx Manufacturing Process	  	 	10	 
			
	 3.5
	 	Cooperation	  	 	10	 
			
	 3.6
	 	Costs	  	 	10	 
		
	 ARTICLE IV FINANCIAL PROVISIONS
	  	 	10	 
			
	 4.1
	 	License Fee	  	 	10	 
			
	 4.2
	 	Milestones Payments	  	 	10	 
			
	 4.3
	 	Royalty Payments by Trevi	  	 	11	 
			
	 4.4
	 	Royalty Term	  	 	11	 
			
	 4.5
	 	Sublicense Income	  	 	11	 
			
	 4.6
	 	Payments; Reports	  	 	12	 
			
	 4.7
	 	Taxes	  	 	12	 
			
	 4.8
	 	United States Dollars	  	 	12	 
			
	 4.9
	 	Currency Conversion	  	 	12	 
			
	 4.10
	 	Late Payments	  	 	12	 
			
	 4.11
	 	Records and Audits	  	 	13	 
		
	 ARTICLE V INTELLECTUAL PROPERTY OWNERSHIP, PROTECTION AND RELATED MATTERS
	  	 	13	 
			
	 5.1
	 	Prosecution and Maintenance of Patent Rights	  	 	13	 
			
	 5.2
	 	Third Party Infringement	  	 	13	 
		
	 ARTICLE VI CONFIDENTIALITY
	  	 	15	 
			
	 6.1
	 	Confidential Information	  	 	15	 

  
 i 

							
	 6.2
	 	Permitted Disclosures	  	 	16	 
			
	 6.3
	 	Limitation on Penwest Disclosure of Penwest Know-how	  	 	16	 
			
	 6.4
	 	Publicity	  	 	16	 
			
	 6.5
	 	Publications	  	 	17	 
			
	 6.6
	 	Return of Confidential Information	  	 	17	 
		
	 ARTICLE VII REPRESENTATIONS AND WARRANTIES; CERTAIN COVENANTS
	  	 	17	 
			
	 7.1
	 	Mutual Representations	  	 	17	 
			
	 7.2
	 	Penwest’s Representations and Warranties	  	 	18	 
			
	 7.3
	 	No Warranty	  	 	18	 
		
	 ARTICLE VIII INDEMNIFICATION
	  	 	19	 
			
	 8.1
	 	Indemnification by Trevi	  	 	19	 
			
	 8.2
	 	Indemnification by Penwest	  	 	19	 
			
	 8.3
	 	Indemnification Procedure	  	 	20	 
			
	 8.4
	 	Limitation of Liability	  	 	20	 
		
	 ARTICLE IX TERM AND TERMINATION
	  	 	20	 
			
	 9.1
	 	Term	  	 	20	 
			
	 9.2
	 	Termination for Convenience	  	 	20	 
			
	 9.3
	 	Termination for Cause	  	 	20	 
			
	 9.4
	 	Penwest Termination	  	 	20	 
			
	 9.5
	 	Patent Challenge Termination	  	 	21	 
			
	 9.6
	 	Effect of Termination	  	 	21	 
			
	 9.7
	 	Survival	  	 	22	 
		
	 ARTICLE X DISPUTE RESOLUTION
	  	 	22	 
			
	 10.1
	 	Referral of Unresolved Matters to Senior Executives	  	 	22	 
			
	 10.2
	 	Arbitration	  	 	22	 
			
	 10.3
	 	Equitable Relief	  	 	23	 
		
	 ARTICLE XI MISCELLANEOUS
	  	 	23	 
			
	 11.1
	 	Governing Law and Jurisdiction	  	 	23	 
			
	 11.2
	 	Force Majeure	  	 	23	 
			
	 11.3
	 	Further Assurances	  	 	24	 
			
	 11.4
	 	Notices	  	 	24	 
			
	 11.5
	 	Assignment	  	 	24	 
			
	 11.6
	 	Affiliate Performance	  	 	24	 
			
	 11.7
	 	Amendment	  	 	25	 
			
	 11.8
	 	Entire Agreement	  	 	25	 

  
 ii 

							
	 11.9
	 	No Benefit to Third Parties	  	 	25	 
			
	 11.10
	 	Waiver	  	 	25	 
			
	 11.11
	 	No Implied Licenses	  	 	25	 
			
	 11.12
	 	Relationship of the Parties	  	 	25	 
			
	 11.13
	 	Severability	  	 	25	 
			
	 11.14
	 	Interpretation	  	 	25	 
			
	 11.15
	 	Counterparts	  	 	26	 

 Exhibit A - Description of Compound 

Exhibit B - Existing Inventory of API 
 Exhibit C - Existing
Penwest Patent Rights 
 Exhibit D - Technology Transfer Plan 

Exhibit E - Letters to FDA transferring INDs 

  
 iii 

 EXCLUSIVE LICENSE AGREEMENT 

This Exclusive License Agreement is entered into this 13th day of May, 2011 (the “Effective Date”), by and between Trevi
Therapeutics, Inc,, a Delaware company, with principal offices located at 52 Charter Ridge Drive, Sandy Hook, CT 06482 (“Trevi”) and Penwest Pharmaceuticals Co,, a Washington corporation, with principal offices located at 100 Endo
Boulevard, Chadds Ford, PA 19317 (“Penwest”). Each of Trevi and Penwest may be referred to, individually, as a “Party”, and, collectively, as the “Parties”. 

RECITALS 
 WHEREAS,
Penwest owns or controls certain patent rights and know-how related to a compound known as nalbuphine hydrochloride, including an extended release formulation; 

WHEREAS, Trevi is interested in obtaining an exclusive license under such patent rights and to such
know-how to develop and commercialize pharmaceutical products incorporating the foregoing compound, and Penwest is willing to grant Trevi such a license, in each case, on the terms and conditions set forth in
this Agreement. 
 NOW, THEREFORE, in consideration of the foregoing and the mutual covenants contained in this Agreement, Penwest
and Trevi, intending to be legally bound, hereby agree as follows: 
 ARTICLE I 

DEFINITIONS 
 When used in
this Agreement, each of the following capitalized terms, whether used in the singular or plural, shall have the meaning set forth in this Article I. 

1.1 “Affiliate” of an entity means any person or entity which, directly or indirectly, controls, is controlled by or is under
common control with such entity. For the purposes of this definition, “control” refers to any of the following: (i) direct or indirect ownership of fifty percent (50%) or more of the voting securities entitled to vote for the election
of directors in the case of a corporation, or of fifty percent (50%) or more of the equity interest with the power to direct management in the case of any other type of legal entity; (ii) status as a general partner in any partnership; or
(iii) any other arrangement where a person or entity possesses, directly or indirectly, the power to direct the management or policies of an entity, whether through ownership of voting securities, by contract or otherwise, 

1.2 “Agreement” means this Exclusive License Agreement, including any and all exhibits, schedules, appendices and other
addenda to it and as it may be amended from time to time in accordance with the provisions of this document. 
 1.3 “API”
means the active pharmaceutical ingredient contained in Licensed Product. 
 1.4 “Clinical Trial Commencement Date” means
the date on which Trevi commences initial activities towards the conduct of a human clinical trial of Licensed Product. 

  
 1 

 1.5 “Combination Product” means any pharmaceutical product containing both a
Licensed Product component and one or more other active pharmaceutical ingredients or other significant components. 
 1.6
“Commercially Reasonable Efforts”, as to a Party, means, as to development activities, the level of efforts and resources at least comparable to those normally used by development stage pharmaceutical companies to conduct an
activity similar to the relevant activity under like circumstances, and as to commercialization activities, the level of efforts and resources at least comparable to those normally used by specialty pharmaceutical companies to conduct an activity
similar to the relevant activity under like circumstances. 
 1.7 “Compound” means nalbuphine hydrochloride or any alternate
form of such compound, including any pharmaceutically acceptable salt, polymorph, crystal form, pro drug or solvate of such compound to the extent such alternate form is covered by Penwest Patent Rights. 

1.8 “Confidential Information” means any and all information, data and materials of a confidential or proprietary nature,
which are provided by or on behalf of one Party or any of its Affiliates to the other Party or any of its Affiliates in connection with this Agreement. 

1.9 “Control” or “Controlled”, other than for purposes of Section 1.1, means the possession of the right
to grant licenses or sublicenses or to disclose proprietary or trade secret information without violating the terms of any agreement or other arrangement with a Third Party and without misappropriating or infringing the proprietary or trade secret
information of a Third Party. 
 1.10 “Cover”, “Covering” or “Covered” means, with respect
to a Patent Right and invention, that, in the absence of ownership of, or a license under, such Patent Right, the practice of such invention would infringe a Valid Claim of such Patent Right (including in the case of a Patent Right that is a patent
application, a Valid Claim of such patent application as if such patent application were an issued patent). 
 1.11 “EMA”
means the European Medicines Agency or any successor agency. 
 1.12 “EU” means the countries of the European Union, as it
is constituted as of the Effective Date and as it may be expanded from time to time. 
 1.13 “Existing Inventory” means the
quantity of API to be transferred by Penwest to Trevi under Section 3.3, as described in Exhibit 3. 
 1.14 “FDA” means
the United States Food and Drug Administration or any successor agency thereto. 
 1.15 “Field” means all uses. 

1.16 “First Commercial Sale”, as to a particular country, means the first commercial sale of a Licensed Product by Trevi or
any of its Affiliates or Sublicensees to a Third Party in such country after approval of the NDA, or if approval of an NDA is not required in such country, then following receipt of Marketing Approval required to market such Licensed Product in such
country. 

  
 2 

 1.17 “GAAP” means United States generally accepted accounting principles applied
on a consistent basis, or any other accounting principles generally accepted for public companies in the United States such as International Financial Reporting Standards (“IFRS”). Unless otherwise defined or stated, financial terms
shall be calculated under GAAP. 
 1.18 “IND” means an Investigational New Drug Application filed with FDA or a similar
application filed with an applicable Regulatory Authority outside of the United States such as a clinical trial application (CTA) or a clinical trial exemption (CTX). 

1.19 “Know-how” means inventions, practices, methods, protocols, formulas, knowledge, know-how, trade secrets, processes, procedures, specifications, assays, skills, experience, techniques, data and results of experimentation and testing, including pharmacological, toxicological, safety, stability
and pre-clinical and clinical test data and analytical and quality control data, patentable or otherwise. 

1.20 “Knowledge of Penwest” means the actual knowledge of the current executive officers of Penwest of events arising after
November 4, 2010. 
 1.21 “Licensed Product” means any product comprising, incorporating or containing any Compound, in
any formulation, and shall specifically include the extended release formulation of Compound made using TIMERx Technology. 
 1.22
“Marketing Approval” means any approval, including price approval, registration, license or authorization from any Regulatory Authority required to market and sell a Licensed Product in a jurisdiction and shall include an approval,
registration, license or authorization granted in connection with an NDA. 
 1.23 “Merger” means the acquisition of Penwest
by Endo Pharmaceuticals Inc. 
 1.24 “NDA” means a New Drug Application, Biologies License Application or equivalent
submission filed with the FDA in connection with seeking Marketing Approval of a Licensed Product, or an equivalent application filed with any equivalent regulatory agency or governmental authority in any jurisdiction other than the United States.

 1.25 “Net Sales” means the gross amount invoiced on sales of Licensed Product in the Territory by Trevi, its Affiliates
and Sublicensees to any Third Party, less the following deductions with respect to the sale of such Licensed Product, in each case, calculated in accordance with GAAP, consistently applied: 

(i) normal trade, cash and quantity discounts and other customary discounts actually given to customers in the ordinary course
of business; 
 (ii) rebates, credits and allowances given by reason of rejections, returns, damaged or defective product or
recalls; 

  
 3 

 (iii) government-mandated rebates and any other compulsory payments, credits,
adjustments and rebates actually paid or deducted; 
 (iv) price adjustments, allowances, credits, chargeback payments,
discounts, rebates, fees, reimbursements or similar payments granted to managed care organizations, group purchasing organizations or other buying groups, pharmacy benefit management companies, health maintenance organizations and any other
providers of health insurance coverage, health care organizations or other health care institutions (including hospitals), health care administrators or patient assistance or other similar programs, or to federal, state/provincial, local and other
governments, including their agencies, or to wholesalers, distributors or other trade customers; 
 (v) reasonable and
customary freight, shipping, insurance and other transportation expenses, if actually borne by such Trevi or its Affiliates or Sublicensees without reimbursement from any Third Party; 

(vi) sales, value-added, excise taxes, tariffs and duties, and other taxes and government charges directly related to the sale,
delivery or use of Licensed Product (but not including taxes assessed directly against the income derived from such sale) net of any credits or allowances received by Trevi or its Affiliates or Sublicensees with respect to such taxes or charges;

 (vii) amounts previously included in Net Sales of Licensed Product that are written off as uncollectible after reasonable
collection efforts, in accordance with standard practices of the applicable party; and 
 (viii) any item, substantially
similar in character or substance to any of the foregoing, calculated in accordance with GAAP consistently applied and customary in the pharmaceutical industry to be deducted in the definition of net sales in a license agreement of this type. 

Notwithstanding anything in this Agreement to the contrary, the transfer of a Licensed Product between or among Trevi, its Affiliates and Sublicensees will
not be considered a sale. 
 Net Sales will include the cash consideration received on a sale and the fair market value of all non-cash consideration. 
 Disposition of Licensed Product for, or use of the Licensed Product in, clinical trials or
other scientific testing, as free samples, or under compassionate use, patient assistance, or test marketing programs or other similar programs or studies shall not result in any Net Sales, however if Trevi or any of its Affiliates or Sublicensees
charges for such Licensed Product, the amount billed will be included in the calculation of Net Sales. 
 In the event a Licensed Product is sold in the
form of a Combination Product, then the Net Sales for any such Combination Product shall be determined by multiplying the Net Sales of the Combination Product during the applicable royalty reporting period, by the fraction, A/(A+B), where A is the
weighted (by sales volume) average sale price of the Licensed Product component 

  
 4 

 
when sold separately in finished form in the country in which the Combination Product is sold and B is the weighted (by sales volume) average sale price of the other active pharmaceutical
ingredients or significant components included in the Combination Product when sold separately in finished form in the country in which the Combination Product is sold, in each case during the applicable royalty reporting period or, if sales of both
the Licensed Product component and the other active pharmaceutical ingredients or significant components did not occur in such period, then in the most recent royalty reporting period during the preceding twelve (12) months in which sales of
both occurred, if any. In the event that such average sale price cannot be determined for both the Licensed Product and all other active pharmaceutical ingredients or significant components included in the Combination Product, then the Parties will
in good faith discuss and agree on a pro-rata allocation of the Net Sales that reflects the Licensed Product’s contribution to the Combination Product on an equitable basis. 

1.26 “Penwest Know-how” means any Know-how
owned or otherwise Controlled by Penwest or any of its Affiliates as of the Effective Date or any time during the Term that (i) is incorporated into Licensed Product or the manufacturing process for Licensed Product; (ii) was used or
generated in the development, manufacture or use of Licensed Product, including preclinical and clinical data; or (iii) is otherwise reasonably necessary or useful to the research, formulation, development (including filing for and obtaining
Marketing Approval), manufacture, import, marketing, sale or use of Licensed Product in the Field. For the sake of clarity, and not in limitation of the foregoing, Penwest Know-how includes Know-how related to the TIMERx Technology as incorporated into an extended release formulation of Compound. 

1.27 “Penwest Patent Rights” means (i) any and all patents and patent applications owned or otherwise Controlled by
Penwest or any of its Affiliates on the Effective Date or at any time during the Term anywhere in the Territory that Cover Penwest Know-how or that otherwise Cover the research, formulation, development,
manufacture, import, marketing, sale or use of Licensed Product in the Field; and (ii) any and all extensions or restorations of the foregoing patents or patent applications by existing or future extension or restoration mechanisms, including
revalidations, reissues, re-examinations and supplementary protection certificates and the like. Penwest Patent Rights includes the patents and patent applications listed in Exhibit C. 

1.28 “Patent Rights” means patents and patent applications and all substitutions, divisions, continuations, continuations-in-part, reissues, reexaminations, supplemental protection certificates and extensions and the like thereof, and all counterparts thereof in any country. 

1.29 “Phase 2 Clinical Study” means a human clinical trial as described in 21 C.F.R. §312.21(b), or an equivalent
clinical trial in a country in the Territory other than the United States. 
 1.30 “Phase 2 Data Package” means a data
package that contains the results of the Phase 2 Clinical Studies of Licensed Product required to be completed prior to commencement of a Phase 3 Clinical Study of Licensed Product in the following form: (i) a statistical analysis of results,
(ii) analysis tables, data listings and illustrative figures, (iii) the table of adverse events, and (iv) a narrative description of serious adverse events, in each case in the format compiled by Trevi, which shall be consistent with
industry standards. 

  
 5 

 1.31 “Phase 3 Clinical Study” means a human clinical trial that is prospectively
designed to demonstrate statistically whether a product is safe and effective for use in humans in the indication being investigated as described in 21 C.F.R. §312.21(c), or an equivalent clinical trial in a country in the Territory other than
the United States. 
 1.32 “Regulatory Authority” means any federal, national, multinational, state, county, city,
provincial, or local regulatory agency, department, bureau or other governmental entity with authority over the marketing, commercialization, manufacture or sale of a pharmaceutical product in the Territory, including the FDA in the United States
and the EMA in the EU. 
 1.33 “Royalty Term” has the meaning set forth in Section 4.4(a). 

1.34 “Sublicensee” means a Third Party to whom Trevi or any of its Affiliates or another Sublicensee grants an express
sublicense under the Penwest Patent Rights and Penwest Know-how to develop, manufacture and commercialize Licensed Product in the Field, provided that the term “Sublicensee” does not include
any wholesaler or third party distributor who resells a Licensed Product purchased from Trevi or any of its Affiliates or other Sublicensees in final finished form (but not necessarily in final packaged, and labeled form), provided that Penwest is
paid the royalty specified in Section 4.3 on the purchase price of such Licensed Product paid by such wholesaler or distributor to Trevi or any of its Affiliates or Sublicensees. 

1.35 “Sublicense Income” means all non-royalty income (whether in the form of upfront
payments, milestone payments or otherwise) received by Trevi or any of its Affiliates from a Sublicensee specifically for the grant of a sublicense of the license granted to Trevi under Section 2.1 hereof to such Sublicensee with respect to the
development, manufacture or commercialization of a Licensed Product (or, if rights in addition to a sublicense under Section 2.1 are granted to such Sublicensee, then reasonably allocated to the grant of the sublicense of rights under
Section 2.1 with respect to such Licensed Product), excluding: 
 (i) amounts received by Trevi or any of its Affiliates
from such Sublicensee as the purchase price for debt or equity securities of Trevi or any of its Affiliates, except that amounts which exceed the fair market value of such debt or equity securities will not be so excluded to the extent otherwise
falling within this definition; 
 (ii) amounts received by Trevi or any of its Affiliates as payments for their actual
reasonably allocated costs (including personnel costs and out-of-pocket costs) to perform research, development or commercialization activities undertaken by Trevi or
its Affiliates for, or in collaboration with, such Sublicensee with respect to Licensed Product; 
 (iii) actual and
reasonable out-of-pocket costs paid to Trevi or any of its Affiliates for the prosecution, maintenance, defense and enforcement of Patent Rights relevant to Licensed
Product; 
 (iv) amounts received by Trevi or any of its Affiliates as reimbursement for costs borne solely by Trevi or any
of its Affiliates, with respect to Third Party claims for which the Sublicensee is obligated to indemnify Trevi or any of its Affiliates, to the extent related to Licensed Product; and 

  
 6 

 (v) amounts paid by such Sublicensee to Trevi or any of its Affiliates or other
Sublicensees to purchase any Licensed Product as to which Penwest will receive a royalty on the direct sale by the Sublicensee. 
 1.36
“Successful Completion” as to a Phase 3 Clinical Study means that the primary endpoints of such study have been met. 
 1.37
“Technology Transfer Plan” means the plan for transfer to Trevi of Penwest Know-how attached to this Agreement as Exhibit D. 

1.38 “Term” means the term of this Agreement determined in accordance with Section 9.1. 

1.39 “Territory” means worldwide. 

1.40 “TIMERx Technology” means Penwest’s proprietary controlled-release drug delivery technology, TIMERx M50A for solid
dosage forms, 
 1.41 “Third Party” means any person other than a Party or any of its Affiliates or their respective
employees. 
 1.42 “Trevi Improvements” means any Know-how owned or otherwise
Controlled by Trevi or any of its Affiliates that constitutes an improvement of the Penwest Know-how, developed by Trevi or any of its Affiliates during the Term, and incorporated into the Licensed Product by
Trevi or any of its Affiliates. 
 1.43 “Trevi Improvement Patent Rights” means Patent Rights owned or Controlled by Trevi
or any to its Affiliates Covering any Trevi Improvement. 
 1.44 “Trevi TIMERx Improvement” means any Trevi Improvement that
consists of a specific improvement to the TIMERx Technology. 
 1.45 “Trevi TIMERx Improvement Patent Right” means any Trevi
Improvement Patent Rights that specifically Cover a Trevi TIMERx Improvement. 
 1.46 “United States” or
“U.S.” means the United States of America and its territories and possessions. 
 1.47 “Valid Claim” means
(i) a claim of an issued and unexpired patent that has not been revoked or held unenforceable or invalid by a decision of a court or other governmental agency of competent jurisdiction from which no appeal can be taken or with respect to which
an appeal is not taken within the time allowed for appeal, and that has not been disclaimed or admitted to be invalid or unenforceable through reissue, disclaimer or otherwise or been dedicated to the public, and (ii) a claim in a pending
patent application that is being prosecuted 

  
 7 

 
and that has not been abandoned, disclaimed, allowed to lapse or finally determined to be unallowable by the applicable governmental authority in a decision from which no appeal can be taken or
from which no appeal is taken within the time allowed for appeal, and that has not been pending for more than [**] from the earliest claimed priority date. 

ARTICLE II 
 LICENSE
GRANT AND PENWEST OPTION 
 2.1 License Grant. Subject to the terms and conditions of this Agreement, Penwest and its Affiliates
hereby grant to Trevi an exclusive license (or sublicense, as the case may be) under the Penwest Patent Rights and the Penwest Know-how, in each case with the right to grant sublicenses, to the extent provided
in Section 2.2, to research, develop, make, have made, use, import, export, market, offer for sale, sell and have sold, Licensed Product in the Territory within the Field. 

2.2 Sublicenses. 
 (a)
Sublicensing. The rights granted to Trevi by Penwest under Section 2.1, may be extended to an Affiliate or sublicensed, in whole or in part, to a Third Party (through multiple levels of sublicensing). Trevi will, promptly after
signature, provide Penwest with an unredacted copy of each agreement with a Sublicensee executed by Trevi or any of its Affiliates. Sublicensees may also extend the rights granted under Section 2.1 to any of their Affiliates. 

(b) Performance by Sublicensees. Trevi will be fully responsible for performance by each Sublicensee of its obligations under this
Agreement. Each sublicense granted by Trevi or by any of its Affiliates or Sublicensees pursuant to this Section 2.2 will contain terms and conditions consistent with those sections of this Agreement applicable to Sublicensees, and specifically
obligations to Penwest of (i) Section 2.4 (Penwest Option to Negotiate), 4.11 (Records and Audits), Article V (Intellectual Property Ownership, Protection and Related Matters), Article VIII (Indemnification), Article IX (Term and
Termination), Article X (Dispute Resolution) and Article XI (Miscellaneous). In addition, each sublicense agreement will contain the following provisions: (i) a requirement that any Sublicensee selling Licensed Product submit applicable sales
or other reports to Trevi to the extent necessary or relevant to the reports required to be made or records required to be maintained under this Agreement; (ii) an audit requirement as to those Sublicensees selling Licensed Product consistent
with that set forth in Section 4.11; and (iii) a requirement that such Sublicensee comply with the confidentiality provisions and restrictions on use of Confidential Information consistent with Article VI with respect to Confidential
Information of Penwest. 
 2.3 Responsibility; Decision-making. During the Term, Trevi will, including through its Affiliates and
Sublicensees, have sole responsibility for and sole decision-making authority with respect to, the research, development, manufacture, marketing, sale and use of Licensed Product in the Field, and except as otherwise expressly set forth in this
Agreement, will be responsible for all of the costs and expenses associated with such activities during the Term. Trevi shall use its Commercially Reasonable Efforts to develop and commercialize Licensed Product in the Territory. 

  
 8 

 2.4 Penwest Option to Negotiate. Trevi hereby grants to Penwest a first right of
negotiation to re-acquire Penwest’s rights under the Penwest Know-how and the Penwest Patent Rights with respect to Licensed Product, and to acquire a license to
Trevi Improvements and Trevi Improvement Patent Rights for the research, development, manufacture and commercialization of Licensed Product (the “Reacquisition Option”). Penwest must exercise the Reacquisition Option by delivering
written notice to Trevi within [**] of delivery to Penwest by Trevi of the Phase 2 Data Package (the “Exercise Notice”). Upon receipt of the Exercise Notice, the Parties will negotiate in good faith the terms of a license agreement,
at then current market rates for deals at a similar stage with a product of similar market potential as Licensed Product. In the event Penwest does not provide the Exercise Notice within [**] of delivery to Penwest by Trevi of the Phase 2 Data
Package, or if the Parties have not executed a definitive agreement under the preceding sentence within [**] of the date of Trevi’s receipt of the Exercise Notice (the “Exclusive Negotiation Period”), despite good faith
negotiations, then Trevi shall thereafter be free to enter into an agreement with one or more Third Parties granting such Third Parties the right to research, develop, manufacture or commercialize Licensed Product, and Penwest will no longer have a
Reacquisition Option, provided that Trevi will not, during the [**]period following the end of the Exclusive Negotiation Period, enter into an agreement with a Third Party on terms more favorable to such Third Party than those last offered to
Penwest, unless Trevi has first offered such terms to Penwest. 
 2.5 Trevi License Grant. Trevi hereby grants to Penwest a non-exclusive royalty-free license (with the right to sublicense) under the Trevi TIMERx Improvement Patent Rights to use and practice any Trevi TIMERx Improvement for the development, design or manufacture of
products other than the Licensed Product, provided, that, to the extent that Trevi or any of its Affiliates is required to pay any license fee, milestone payment, royalty or any other payment to any Third Party as a result of Penwest’s exercise
of its rights pursuant to the license granted under the preceding sentence or in connection with the sale of any resulting products, Trevi shall fully disclose such payment obligations within [**] of the grant of such Third Party license, Penwest
may elect not to accept the grant of the license to any such Third Party intellectual property with corresponding payment obligations upon [**] written notice to Trevi from the date of Penwest’s receipt of notification of such payment
obligations. If Penwest chooses to accept such license, Penwest shall pay such amounts to Trevi, or, as directed by Trevi, directly to such Third Party, on each occasion within [**] of receipt of the applicable invoice from Trevi, and appropriate
supporting documentation. 
 ARTICLE III 

TECHNOLOGY TRANSFER AND TRANSITION ACTIVITIES 

3.1 Know-how Transfer. Penwest agrees to transfer to Trevi the Penwest Know-how specified in the Technology Transfer Plan, including all preclinical and clinical data, and manufacturing information, if any, in accordance with the time-lines and other requirements set forth in such
plan. In the event Penwest Know-how is in the possession of a Third Party, Penwest will, at the request of Trevi, use Commercially Reasonable Efforts, to obtain such information from such Third Party so that
such information may be made available to Trevi under this Section. All external costs incurred in connection with this effort will be the responsibility of Trevi. 

  
 9 

 3.2 Regulatory Transition. Penwest agrees to transfer the INDs for Licensed Product to
Trevi. Concurrent with execution of this Agreement, and as a condition to Trevi’s payments obligation under Section 4.1, Penwest will execute and deliver to Trevi for mailing, letters to the FDA transferring the INDs related to Licensed
Product to Trevi, such letters to be in the form attached to this Agreement as Exhibit E. In addition, Penwest will use Commercially Reasonable Efforts to take such other actions as any Regulatory Authority may request to effect the transfer of INDs
related to Licensed Product to Trevi. Prior to transfer of the IND, Penwest will continue to perform such obligations as are required under applicable law with respect to an IND holder. 

3.3 Supply of Material/ Technology Transfer. Penwest will transfer to Trevi all quantities of API in Penwest’s possession or
control, including the Existing Inventory, with delivery costs to be paid by Trevi. Penwest will also furnish to Trevi those documents listed in the Technology Transfer Plan, with any delivery or retrieval costs to be paid by Trevi. 

3.4 Transfer of TIMERx Manufacturing Process. At the request of Trevi, Penwest will provide to Trevi copies of excerpts from the
relevant laboratory notebooks and manufacturing records as necessary to enable Trevi to replicate and implement the manufacturing process for the TIMERx Technology, provided, however, that Trevi may use such information solely to manufacture
Licensed Product pursuant to this Agreement and for no other purpose. 
 3.5 Cooperation. Except as set forth in Sections 3.1, 3.2 and
3.3, Penwest will have no obligation to provide any on-going assistance in connection with technology transfer activities contemplated under this Agreement, except that Penwest will permit Trevi to consult
with Penwest’s former employees who have possession of relevant information related to the research, development, manufacture or use of Licensed Product, and will permit such persons to share such information, including relevant Confidential
Information of Penwest, with Trevi for purposes of this Agreement, so long as such consulting occurs under confidentiality obligations at least as stringent as those in Article VI of this Agreement. 

3.6 Costs. Each Party will pay its own internal costs associated with technology transfer activities to be provided under this
Section 3. To the extent any technology transfer activities to be provided under this Section require external resources, Trevi shall bear the costs of such external resources, provided that such activities and costs are expressly set forth in
the Technology Transfer Plan or are otherwise approved in writing in advance by Trevi. 
 ARTICLE IV 

FINANCIAL PROVISIONS 
 4.1
License Fee. Subject to Section 3.2, within ten (10) days of the Effective Date, Trevi will pay to Penwest a non-creditable, non-refundable license fee
of $25,000. 
 4.2 Milestones Payments. Subject to the terms and conditions of this Agreement, Trevi will pay Penwest a milestone
payment upon the first occurrence of each of the following events, no later than [**] after the occurrence of the event: 

  
 10 

					
	 Event Milestone
	 	Event Milestone Payment	 
	 (i) Successful Completion of the first Phase 3 Clinical Study
	 	$	250,000	 
	 (ii)  Receipt of Marketing Approval of Licensed Product in the United States
	 	$	750,000	 

 Each of the above milestone payments will be payable only upon the first occurrence of the applicable event, regardless of how
many times the event is ultimately achieved. 
 4.3 Royalty Payments by Trevi. Trevi will pay to Penwest royalties on Net Sales of
Licensed Product in the Field in the Territory by Trevi and its Affiliates and Sublicensees, calculated using the following royalty rates: 
  

			
	 Portion of Calendar Year Net Sales of such Licensed
Product
	 	 Royalty Rate

	 On that portion of calendar year Net Sales of the Licensed Product less than $[**]
	 	 [**]%

	 On that portion of calendar year Net Sales of the Licensed Product equal to or greater than
$[**] but less than or equal to $[**]
	 	 [**]%

	 On that portion of calendar year Net Sales of the Licensed Product greater than $[**]
	 	 [**]%

 4.4 Royalty Term. 

(a) Royalties. Royalties under Section 4.3 will be payable on a country by country and Licensed Product-by-Licensed Product basis during the period commencing on the First Commercial Sale of such Licensed Product in the applicable Field in such country and ending upon the later of (i) the date of
expiration, unenforceability or invalidation of the last Valid Claim of Penwest Patent Rights Covering such Licensed Product in such country of sale, and (ii) ten (10) years from the date of First Commercial Sale in such country (the
“Royalty Term”). 
 (b) End of Patent Royalty Term. Upon expiration of the Royalty Term, as the case may be, in the
country of sale, the license granted to Trevi and its Affiliates and Sublicenses under Article II will convert to a know-how and trademark royalty of [**]% of Net Sales. 

4.5 Sublicense Income. In addition to paying Penwest a royalty on the Net Sales by the Sublicensee under Section 4.3, Trevi will
pay Penwest a percentage of any Sublicense Income received with respect to a Licensed Product to the extent not included in Net Sales, determined based on the date of the definitive agreement under which the sublicense was granted, as follows: 

 

			
	 Stage at Execution of definitive agreement with the
Sublicensee
	  	 Penwest Portion

	 [**]
	  	 [**]%

	 [**]
	  	 [**]%

  
 11 

 4.6 Payments; Reports. Within [**] of the end of calendar quarter, Trevi shall deliver to
Penwest an estimate of the royalties due on Net Sales and payments due on Sublicense Income for such calendar quarter. Trevi will pay royalties due on Net Sales, and payments due on Sublicense Income, received in a calendar quarter within [**] of
the end of such calendar quarter. Within [**] after the end of each calendar quarter, Trevi will submit to Penwest a report, providing in reasonable detail an accounting of all Net Sales by Trevi and its Affiliates and Sublicensees in the Territory
(including, in each case, an accounting of all unit sales of the Licensed Product and a calculation of the deductions from gross invoice price to Net Sales in accordance with the definition of Net Sales) made during such calendar quarter and
describing any Sublicense Income received during such period. 
 4.7 Taxes. Trevi will make all payments to Penwest under this
Agreement without deduction or withholding except to the extent that any such deduction or withholding is required by applicable law to be made on account of Taxes (as that term is defined below). Any Tax required to be withheld under applicable law
on amounts payable under this Agreement will promptly be paid by Trevi or its Affiliates or Sublicensees on behalf of Penwest to the appropriate governmental authority, and Trevi will furnish Penwest with proof of payment of such Tax. Any such Tax
required to be withheld will be an expense of and borne by Penwest. Trevi will give notice of its intention to begin withholding any such Tax in advance and will use Commercially Reasonable Efforts to reduce or eliminate such Tax on payments made to
Penwest hereunder. The Parties will cooperate with respect to all documentation required by any relevant government taxing authority or reasonably requested by either Party to secure a reduction in the rate of applicable withholding Taxes. Solely
for purposes of this Section 4.7, “Tax” or “Taxes” means any present or future taxes, levies, imposts, duties, charges, assessments or fees of any nature (including interest, penalties and additions thereto)
that are imposed by a government authority, but not including Trevi income taxes. 
 4.8 United States Dollars. All dollar ($) amounts
specified in this Agreement are United States dollar amounts. 
 4.9 Currency Conversion. All payments to be made by Trevi to Penwest
will be made in U.S. Dollars, to a bank account designated by Penwest. In the case of sales outside the United States, payments received by Trevi will be expressed in the U.S. Dollar equivalent calculated on a quarterly basis in the currency of
the country of sale and converted to their U.S. Dollar equivalent using the average rate of exchange over the applicable calendar quarter to which the sales relate, in accordance with GAAP and the then current standard methods of Trevi or the
applicable Sublicensee, to the extent reasonable and consistently applied. Trevi will provide Penwest with the specific exchange rate translation methodology used for a particular country or countries. 

4.10 Late Payments. Trevi will pay interest to Penwest on the aggregate amount of any payments that are not paid on or before the date
such payments are due under this Agreement at a rate per annum equal to the lesser of [**] percent ([**]%) per month or the highest rate permitted by applicable law, calculated based on the number of days such payments are paid after the date such
payments are due. 

  
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 4.11 Records and Audits. Trevi will keep complete and accurate records relating to the
calculations of Net Sales generated in the then current calendar year, and during the preceding [**]. Penwest will have the right, [**] at its own expense, to have a nationally recognized, independent, certified public accounting firm, selected by
it and reasonably acceptable to Trevi, review any such records of Trevi and its Affiliates and Sublicensees (the “Audited Party”) in the location(s) where such records are maintained by the Audited Party upon reasonable written
notice (which shall be no less than [**] prior written notice) and during regular business hours and under obligations of strict confidence, for the sole purpose of verifying the basis and accuracy of payments made under Section 4.3 and 4.5
within the [**] period preceding the date of the request for review. No calendar year will be subject to audit under this Section more than [**] except for cause. Trevi will receive a copy of each such report concurrently with receipt by Penwest.
Should such inspection lead to the discovery of a discrepancy to Penwest’s detriment, Trevi will, within [**] after receipt of such report from the accounting firm, pay any undisputed amount of the discrepancy, plus interest on the underpayment
at a rate per annum equal to the lesser of [**] percent ([**]%) per month or the highest rate permitted by applicable law, calculated from the date the underpayment was made until the date of payment to Penwest of the underpayment. Penwest will pay
the full cost of the review unless the underpayment of amounts due to Penwest is greater than [**] percent ([**]%) of the amount due for the entire period being examined, in which case Trevi will pay the cost of such review. Any undisputed
overpayment of royalties by Trevi revealed by an examination will be paid by Penwest within [**] of Penwest’s receipt of the applicable report. Any disagreement regarding the results of any audit conducted under this Section will be subject to
the dispute resolution provisions set forth in Article X. 
 ARTICLE V 

INTELLECTUAL PROPERTY OWNERSHIP, PROTECTION 

AND RELATED MATTERS 
 5.1
Prosecution and Maintenance of Patent Rights. Trevi will have responsibility and decision-making authority, including responsibility for all fees and costs, with respect to, filing, conducting prosecution, and maintaining (including the
defense of any interference or opposition proceedings) all Penwest Patent Rights (not including for this purpose Patent Rights that are of general applicability with respect to the TIMERx Technology), including decisions related to continued
prosecution. Trevi shall consult with Penwest and shall keep Penwest informed regarding all matters relating to such prosecution, but shall directly instruct Penwest outside counsel as to all matters relating to Penwest Patent Rights. If at any time
Penwest and Trevi disagree and cannot reach agreement regarding prosecution of any Penwest Patent Rights, Penwest may retake responsibility for prosecution of those rights by notifying Trevi in writing. Upon such notification, Penwest shall
thereafter have responsibility and decision-making authority, including responsibility for all fees and costs for all Penwest Patents Rights identified in the notice. 

5.2 Third Party Infringement. 

(a) Notices. Each Party will promptly report in writing to the other Party any (i) known or suspected infringement of any Penwest
Patent Rights, or (ii) unauthorized use or misappropriation of any Penwest Know-how by a Third Party, of which such Party becomes aware, in each case only to the extent relevant to Licensed Product or the
development, manufacture, commercialization or use of Licensed Product in the Field in the Territory, and will provide the other Party with all available information evidencing such infringement, or unauthorized use or misappropriation. 

  
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 (b) Trevi First Right to Enforce Certain Penwest Patent Rights. Trevi or its designated
Affiliate or Sublicensee will have the first right, but not the obligation, to initiate a suit or take other appropriate action required to prevent or abate actual or threatened infringement or misappropriation of, or otherwise protect or enforce,
the Penwest Patent Rights and/or defend against a Third Party claim of invalidity or unenforceability of Penwest Patent Rights. Penwest and its Affiliates will join such suit if the relevant court would lack jurisdiction if Penwest or such Affiliate
were absent from such suit and Penwest and such Affiliates will execute such legal papers and cooperate in the prosecution of such suit as may be reasonably requested by Trevi; provided, that Trevi will promptly reimburse all out-of-pocket expenses (including reasonable attorneys’ fees and expenses) incurred by Penwest and such Affiliates in connection with such requested cooperation. 

(c) Penwest Rights if Trevi Elects Not to Proceed. If Trevi does not initiate a suit or take other appropriate action pursuant to
Section 5.2(b) within [**] after knowledge of such infringement or misappropriation or, in the case of receipt of a notice letter sent by a Third Party pursuant to the requirements of 21 U.S.C. § 355(b)(2)(A)(iv) or 355(j)(2)(A)(vii)(IV)
or under any analogous provisions, within [**] before any statutory or regulatory deadline for filing such suit, then Penwest will have the immediate right to initiate a suit or take other appropriate action that it believes is reasonably required
to prevent or abate actual or threatened infringement or misappropriation of, or otherwise to protect or enforce the relevant Penwest Patent Rights. Trevi and its Affiliates will join such suit if the relevant court would lack jurisdiction if Trevi
or such Affiliates were absent from such suit and Trevi and such Affiliates will execute such legal papers and cooperate in the prosecution of such suit as may be reasonably requested by Penwest; provided, that Penwest will promptly reimburse all out-of-pocket expenses (including reasonable attorneys’ fees and expenses) incurred by Trevi and such Affiliates in connection with such requested cooperation. 

(d) Right to Enforce Know-how. Responsibility for preventing or abating actual or threatened
infringement or misappropriation of, or otherwise protecting or enforcing Penwest Know-how will be determined in the same manner as the right to enforce Penwest Patent Rights under paragraph (b) and (c).
The enforcing Party shall keep the other Party informed of the status of all enforcement activities, and shall consider in good faith all comments of the other Party regarding any aspect of such enforcement. 

(e) Conduct of Certain Actions; Costs. The Party initiating suit under this Section 5.2 will have the sole and exclusive right to
select counsel for any suit initiated by it pursuant to this Section. The initiating Party will assume and pay all of its own out-of-pocket costs incurred in connection
with any litigation or proceedings initiated by it pursuant to this Section, including the fees and expenses of the legal counsel selected by it. 

  
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 (f) Recoveries. 

(i) If Trevi initiates suit as permitted in accordance with Section 5.2(b) or, with respect to Penwest Know-how, in the same manner as set forth in Section 5.2(b), any damages, settlements, accounts of profits, or other financial compensation actually paid to Trevi by a Third Party based upon such suit, after
deducting Trevi’s actual out of pocket expenses (including reasonable attorneys’ fees and expenses) incurred in pursuing such suit (such net amount, the “Recovery”), will be treated as Sublicense Income, and will be
subject to the payment obligations under Section 4.5, with Trevi retaining the balance after such payment. 
 (ii) If
Penwest initiates suit pursuant to Section 5.2(c) or with respect to Penwest Know-how, in the same manner as set forth in Section 5.2(c), Penwest may retain any damages, settlements, accounts of
profits, or other financial compensation recovered from a Third Party based upon such suit. 
 ARTICLE VI 

CONFIDENTIALITY 
 6.1
Confidential Information. During the Term and for a period of [**] after any termination or expiration of this Agreement, each Party agrees to keep in confidence and not to disclose to any Third Party, or use for any purpose, except pursuant
to, and in order to carry out, the terms and objectives of this Agreement (which, in the case of Trevi and its Affiliates and Sublicensees, includes activities contemplated by the licenses granted in Sections 2.1) or as otherwise specifically
permitted under this Agreement, any Confidential Information of the other Party. The terms of this Agreement will be considered Confidential Information of both Parties, subject to permitted disclosures as set forth in this Article VI. The
restrictions on the disclosure and use of Confidential Information set forth in the first sentence of this Section 6.1 will not apply to any Confidential Information that: 

(i) is or becomes part of the public domain through no fault of the receiving Party; or 

(ii) is disclosed to the receiving Party by a Third Party having a legal right to make such disclosure without violating any
confidentiality or non-use obligation that such Third Party has to the disclosing Party and provided such Third Party is not disclosing such information on behalf of the disclosing Party. 

In addition, if either Party is required to disclose Confidential Information of the other Party by regulation, law or legal process, including by the rules
or regulations of the United States Securities and Exchange Commission or similar regulatory agency in a country other than the United States or of any stock exchange or Nasdaq, such Party shall, to the extent practicable, provide prior written
notice and a copy of such intended disclosure to such other Party if possible under the circumstances, will consider in good faith the other Party’s comments, will disclose only such Confidential Information of such other Party as is required
to be disclosed and will cooperate in the disclosing Party’s efforts to obtain a protective order or to limit the scope of the required disclosures. Notwithstanding anything in this Agreement to the contrary, either Party may disclose to bona
fide potential or existing investors or lenders, potential acquirors/acquirees, 

  
 15 

 
and, in the case of Trevi, to potential and existing sublicensees and collaborators, and to such Party’s consultants and advisors, the existence and terms of this Agreement to the extent
necessary in connection with a proposed equity or debt financing of such Party, or a proposed acquisition or business combination or transaction, so long as such recipients are bound in writing to maintain the confidentiality of such information.

 6.2 Permitted Disclosures. Each Party agrees that it and its Affiliates will provide or permit access to Confidential Information
received from the other Party and such Party’s Affiliates and representatives only to the receiving Party’s employees, consultants, advisors and bona fide potential acquirors, Third Party contractors, potential and existing Sublicensees
and distributors, in each case who, in such Party’s reasonable judgment, have a need to know such Confidential information to assist the receiving Party with the activities contemplated by this Agreement (which, in the case of Trevi and its
Affiliates and Sublicensees, includes activities contemplated by the license granted in Sections 2.1) or in connection with a potential business relationship or investment that would encompass Licensed Product, and who are subject to obligations of
confidentiality and non-use with respect to such Confidential Information similar to the obligations of confidentiality and non-use of the receiving Party under
Section 6.1. Penwest and Trevi shall each remain responsible for any failure by its Affiliates, and its and its Affiliates’ respective employees, consultants, advisors, contractors, investigators, sublicensees and distributors, to treat
such Confidential Information as required under Section 6.1 (as if such Affiliates, employees, consultants, advisors, contractors, sublicensees and distributors were Parties directly bound to the requirements of Section 6.1). Each Party
may also disclose Confidential Information of the other Party to Regulatory Authorities and other governmental authorities, but solely in connection with the activities contemplated by this Agreement. 

6.3 Limitation on Penwest Disclosure of Penwest Know-how. During the Term of this Agreement,
Penwest will not disclose Penwest Know-how that is specific to Licensed Product or the development, manufacture, commercialization or use of Licensed Product to any Third Party without the express written
consent of Trevi or as otherwise permitted under this Agreement. 
 6.4 Publicity. Neither Party will issue a press release or public
announcement relating to the terms of this Agreement without the prior written approval of the other Party, which approval shall not be unreasonably withheld or delayed, except that (i) a Party may issue such press release or public
announcement if the contents of such press release or public announcement, to the extent related to the terms of this Agreement, are identical with a previously approved press release or have otherwise previously been made public other than through
a breach of this Agreement, and (ii) a Party may issue such a press release or public announcement if required by applicable law, including by the rules or regulations of the United States Securities and Exchange Commission (SEC) or similar
regulatory agency in a country other than, the United States or of any stock exchange or Nasdaq; provided that such Party complies with the notice and review provisions set forth in this Section. In the event Penwest is required by applicable law to
publicly disclose any of the results generated by Trevi or any of its Affiliates or Sublicensees or any information provided by Trevi related to Licensed Product or either Party is required by applicable law to disclose the terms of this Agreement,
such Party will give the other Party at least [**] prior written notice, but only if and to the extent reasonably 

  
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practicable, will provide to such other Party a copy of the required disclosure, will, if requested by such other Party, to the extent permitted by applicable law, request confidential treatment
of any financial and other materials terms of this Agreement not previously disclosed under this Section, and will consider in good faith any other comments of such other Party on such public disclosure. 

6.5 Publications. Trevi and its Affiliates and Sublicensees shall have the sole right to publish the results of development,
manufacturing, commercialization and use of Licensed Product during the Term. 
 6.6 Return of Confidential Information. Upon
termination of this Agreement prior to the end of the Term, the receiving Party shall, at the request of, and as directed by, the disclosing Party, return or destroy Confidential Information of the disclosing Party in the receiving Party’s
possession, and shall destroy any reports or notes in receiving Party’s possession to the extent containing the disclosing Party’s Confidential Information, and any electronic copies of any of the foregoing, provided that (i) the
receiving Party may retain one copy of Confidential Information of the disclosing Party for archival purposes, and (ii) neither Party shall be required to return or destroy copies of the other Party’s Confidential Information stored on
automatically created system back-up media. 
 ARTICLE VII 

REPRESENTATIONS AND WARRANTIES; CERTAIN COVENANTS 

7.1 Mutual Representations. Each Party hereby represents and warrants to the other Party, as of the Effective Date, as follows: 

(a) It is duly organized and validly existing under the laws of its jurisdiction of incorporation and has the corporate power and authority to
execute and deliver this Agreement and to perform its obligations hereunder. 
 (b) The execution, delivery and performance of this Agreement
by such Party has been duly and validly authorized and approved by proper corporate action on the part of such Party. Such Party has taken all other action required by applicable law, its certificate of incorporation or by-laws or any agreement to which it is a party or by which it or its assets are bound, to authorize such execution, delivery and performance. Assuming due authorization, execution and delivery on the part of the
other Party, this Agreement constitutes a legal, valid and binding obligation of such Party. 
 (c) The execution and delivery of this
Agreement, and the performance as contemplated hereunder, by such Party will not violate any applicable law. 
 (d) Neither the execution and
delivery of this Agreement nor the performance hereof by such Party requires such Party to obtain any permit, authorization or consent from any governmental authority (except for any Marketing Approvals, pricing or reimbursement approvals,
manufacturing-related approvals or similar approvals necessary for development, manufacture or commercialization of Licensed Products), or from any other person, and such 

  
 17 

 
execution, delivery and performance by such Party, including the granting of the licenses granted under this Agreement, will not result in the breach of or give rise to any conflict, termination
of, rescission, renegotiation or acceleration under or trigger any other rights under any agreement or contract to which such Party may be a party existing as of the Effective Date. 

(e) Neither Party nor any of its Affiliates has been debarred or is subject to debarment pursuant to Section 306 of the United States
Federal Food, Drug, and Cosmetic Act, or is the subject of a conviction described in such section. 
 7.2 Penwest’s
Representations and Warranties. Penwest hereby makes the following representations and warranties to Trevi as of the Effective Date, provided that Trevi understands and agrees that the knowledge of Penwest with respect to the matters described
below is limited to any actual Knowledge of Penwest arising after the date of the Merger: 
 (a) Penwest has the right to grant to Trevi the
rights and licenses described in this Agreement. 
 (b) To the Knowledge of Penwest, Exhibit C contains a complete and correct list of
all existing Penwest Patent Rights. 
 (c) To the Knowledge of Penwest, Penwest has not received any written notice of (i) any claim
that any patent or trade secret right owned or controlled by a Third Party would be infringed or misappropriated by the manufacture, use, sale, offer for sale or importation of Licensed Products in the Field, or (ii) any threatened claims or
litigation seeking to invalidate or otherwise challenge the Penwest Patent Rights or Penwest’s rights therein. 
 (d) To the Knowledge
of Penwest, the Penwest Patent Rights that are pending patent applications as of the Effective Date are being diligently prosecuted at the respective patent offices. To Penwest’s knowledge, the Penwest Patent Rights that are issued patents have
been maintained properly and correctly and all applicable fees have been paid on or before the due date for payment. 
 (e) To the Knowledge
of Penwest, neither Penwest nor its Affiliates has received written notice from any Regulatory Authority threatening any proceedings with respect to the research, development or manufacture of any Licensed Product in the Field in the Territory. 

7.3 No Warranty. EXCEPT AS OTHERWISE EXPRESSLY SET FORTH IN THIS AGREEMENT, NEITHER PARTY HERETO MAKES ANY REPRESENTATIONS AND NEITHER
PARTY EXTENDS ANY WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, STATUTORY OR OTHERWISE, WITH RESPECT TO THE SUBJECT MATTER OF THIS AGREEMENT (INCLUDING ANY LICENSED PRODUCT), INCLUDING ANY WARRANTY OF MERCHANTABILITY, NONINFRINGEMENT, OR FITNESS
FOR A PARTICULAR PURPOSE. EXCEPT AS EXPRESSLY PROVIDED IN THIS AGREEMENT, PENWEST MAKES NO WARRANTY OR REPRESENTATION AS TO THE VALIDITY OR SCOPE OF THE PENWEST PATENT RIGHTS OR PENWEST KNOW HOW, OR THAT

  
 18 

 
ANY LICENSED PRODUCT WILL BE FREE FROM AN INFRINGEMENT ON PATENTS OR OTHER INTELLECTUAL PROPERTY RIGHTS OF THIRD PARTIES, OR THAT NO THIRD PARTIES ARE IN ANY WAY INFRINGING OR NOT INFRINGING THE
PENWEST PATENT RIGHTS OR PENWEST KNOW HOW COVERED BY THIS AGREEMENT. TREVI DISCLAIMS ANY REPRESENTATION OR WARRANTY THAT THE DEVELOPMENT, MANUFACTURE AND COMMERCIALIZATION OF LICENSED PRODUCT PURSUANT TO THIS AGREEMENT WILL BE SUCCESSFUL OR THAT, IF
COMMERCIALIZED, ANY PARTICULAR SALES LEVEL WILL BE ACHIEVED. 
 ARTICLE VIII 

INDEMNIFICATION 
 8.1
Indemnification by Trevi. Trevi will indemnify, hold harmless, and defend Penwest, its Affiliates, and their respective directors, officers, employees and agents (the “Penwest Indemnitees”) from and against any and all
damages, liabilities, costs, expenses and amounts paid in settlement (collectively, “Losses”) incurred in connection with any Third Party claim arising out of or resulting from, directly or indirectly; (i) any breach of, or
inaccuracy in, any representation or warranty made by Trevi in this Agreement, or any breach or violation of any term of this Agreement by Trevi; (ii) the negligence or willful misconduct of Trevi, its Affiliates and their respective
Sublicensees, and their respective directors, officers, employees and agents; (iii) infringement, misappropriation or encroachment of any Third Party’s personal, contractual or property rights by Trevi, its officers, directors, employees,
Sublicensees, agents or Affiliates or (iv) the research, development, manufacture, commercialization, or use of Licensed Product by Trevi and its Affiliates and Sublicensees in the Territory in the Field under this Agreement. Notwithstanding
the foregoing or anything in this Agreement to the contrary, Trevi will have no obligation to indemnify the Penwest Indemnitees for any Losses as to which Penwest is obligated to indemnify Trevi under Section 8.2. 

8.2 Indemnification by Penwest. Penwest will indemnify, hold harmless, and defend Trevi, its Affiliates and their respective directors,
officers, employees and agents (the “Trevi Indemnitees”) from and against any and all Losses incurred in connection with any Third Party claim arising out of or resulting from, directly or indirectly, (i) any breach of, or
inaccuracy in, any representation or warranty made by Penwest in this Agreement, or any breach or violation of any term of this Agreement by Penwest; (ii) the negligence or willful misconduct of any Penwest Indemnitee; or (iii) the
research, development, manufacture or use of Licensed Product by or on behalf of Penwest or any of its Affiliates prior to the Effective Date. Notwithstanding the foregoing, or anything in this Agreement to the contrary, Penwest will have no
obligation to indemnify the Trevi Indemnitees for any Losses as to which Trevi is obligated to indemnify Penwest under Section 8.1. The Parties expressly agree that Penwest’s indemnification obligations hereunder shall in no event exceed
the greater of (i) $12,500 for claims arising before the payment of the milestone in Section 4.2(ii), and (ii) $100,000 for claims arising after the payment of the milestone in Section 4.2(ii). Except with respect to claims for equitable relief made
with respect to breaches of any covenant or agreement contained in this Agreement, the rights of the Trevi Indemnitees under this ARTICLE VIII shall be the sole and exclusive remedies of the Trevi Indemnitees with respect to claims under, or
otherwise relating to the transactions that are the subject of, this Agreement. 

  
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 8.3 Indemnification Procedure. In the event of any such claim against any Trevi Indemnitee
or Penwest Indemnitee (individually, an “Indemnitee”), the indemnified Party shall promptly notify the other Party in writing of the claim and the indemnifying Party shall manage and control, at its sole expense, the defense of the
claim and its settlement. The indemnified Party will cooperate with the indemnifying Party and may, at the indemnifying Party’s option and expense, be represented in any such action or proceeding. The indemnifying Party will not be liable for
any settlements, litigation costs or expenses incurred by any Indemnitee without the indemnifying Party’s prior written authorization. Notwithstanding the foregoing, if the indemnifying Party believes that any of the exceptions to its
obligation of indemnification of the Indemnitees set forth in this Article 8 may apply, the indemnifying Party will promptly notify the Indemnitees, who shall then have the right to be represented in any such action or proceeding by separate
counsel at their expense; provided that the indemnifying Party will be responsible for payment of such expenses if the Indemnitees are ultimately determined to be entitled to indemnification from the indemnifying Party. 

8.4 Limitation of Liability. NEITHER PARTY HERETO WILL BE LIABLE FOR SPECIAL, INCIDENTAL, CONSEQUENTIAL OR PUNITIVE DAMAGES ARISING OUT
OF THIS AGREEMENT OR THE EXERCISE OF ITS RIGHTS HEREUNDER, INCLUDING LOST PROFITS ARISING FROM OR RELATING TO ANY BREACH OF THIS AGREEMENT, REGARDLESS OF ANY NOTICE OF SUCH DAMAGES, EXCEPT AS A RESULT OF A PARTY’S WILLFUL MISCONDUCT. NOTHING IN
THIS SECTION 8.4 IS INTENDED TO LIMIT OR RESTRICT THE INDEMNIFICATION RIGHTS OR OBLIGATIONS OF EITHER PARTY. 
 ARTICLE IX 

TERM AND TERMINATION 
 9.1
Term. This Agreement will become effective as of the Effective Date, and will continue in full force and effect until terminated in accordance with this Article IX (“Term”). 

9.2 Termination for Convenience. This Agreement may be terminated at any time by Trevi upon one hundred eighty (180) days prior
written notice to Penwest. During such one hundred eighty (180) day notice period: (i) Trevi shall continue to make all payments to Penwest that would otherwise become due under this Agreement, (ii) the Parties shall continue to
perform under the Agreement, and (iii) ongoing clinical trials shall be continued or closed down, as agreed by the Parties, but no new clinical trials will be undertaken. 

9.3 Termination for Cause. This Agreement may be terminated at any time during the Term upon written notice by either Party if the other
Party is in material breach of its obligations hereunder, and has not cured such material breach within [**] in the case of Trevi’s failure to pay any amounts due hereunder) after written notice describing the nature of such material breach is
provided to the breaching Party. 
 9.4 Penwest Termination. Penwest may terminate this Agreement upon written notice to Trevi in the
event the Clinical Trial Commencement Date has not occurred by April 30, 2012. In addition, to the extent permitted by applicable law, Penwest may terminate this Agreement by giving written notice of termination to Trevi within thirty
(30) days of the filing of bankruptcy or bankruptcy of Trevi or the making by Trevi of any assignment for the benefit of creditors. Termination shall be effective upon the date specified in such notice. 

  
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 9.5 Patent Challenge Termination. If Trevi or any of its Sublicensees challenge the
validity or enforceability of any Penwest Patent Rights Covering Licensed Product, and such challenge is not terminated within thirty (30) days of Trevi’s receipt of written notice from Penwest, this Agreement shall immediately terminate
and all licenses granted hereunder shall be revoked. 
 9.6 Effect of Termination. 

(a) Pre-Termination Obligations; Transfer of Information and Filings. Upon the termination of
this Agreement for any reason, nothing herein shall be construed to release either Party from any obligation that matured prior to the effective date of such termination. Trevi shall remain obligated to provide an accounting for and to pay Royalties
earned. In the event of termination, (i) the licenses granted hereunder shall terminate; (ii) Trevi shall have no further rights under Penwest Patent Rights or Penwest Know-how to develop,
manufacture or market the Licensed Product or any product containing Licensed Product for use in the Field, or otherwise to use the Penwest Patent Rights or Penwest Know How; (iii) all rights granted hereunder shall revert to Penwest for the
benefit of Penwest; and (iv) Trevi shall, as promptly as practicable, transfer to Penwest or Penwest’s designee: (a) possession and ownership of all governmental or regulatory correspondence, conversation logs, filings and approvals
(including all Marketing Approvals and pricing and reimbursement approvals) relating to the development, manufacture or commercialization of the Licensed Product in the Field and all product trademarks then being used in connection with Licensed
Product, other than Trevi’s corporate trademarks; and (b) all safety data and other adverse event data in Trevi’s possession or Control. In addition, Trevi shall, free of charge, transfer to Penwest or destroy (at Penwest’s
election) all API and Licensed Product in Trevi’s possession or control. Notwithstanding the foregoing, Trevi shall be entitled to sell any completed inventory of Licensed Product which remain on hand as of the date of the termination, and to
sell new inventory to the extent necessary to satisfy its contractual and legal obligations, so long as Trevi pays to Penwest the royalties applicable to said subsequent sales in accordance with the terms and conditions as set forth in this
Agreement; provided that no sales shall be permitted after the expiration of [**] after the date of termination. Trevi will execute all documents and take all such further actions, as may be reasonably requested by Penwest in order to give effect to
the preceding sentences as soon as practicable. 
 (b) License Grant. In the event of termination of this Agreement by Penwest under
Section 9.3 or 9.4, automatic termination under Section 9.5 or termination by Trevi under Section 9.2, Trevi will be deemed to have granted to Penwest a perpetual, royalty free (except as set forth below), worldwide, exclusive,
sublicensable, license under any Trevi Improvement Patent Rights and Trevi Improvements to the extent necessary to manufacture, market, sell or use Licensed Product in the Field in the Territory. Notwithstanding anything in this Section to the
contrary, in the event Trevi or any of its Affiliates or sublicensees is required to make payments to any Third Party by reason of the licenses granted to Penwest under this paragraph (b) and based on the development, manufacture or sale of
Licensed Product by or on behalf of Penwest 

  
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or any of its Affiliates or sublicensees, Penwest will pay such amounts due by Trevi or any of its Affiliates or Sublicensees to such Third Party by reimbursing Trevi or paying such amounts
directly to such Third Party, as directed by Trevi, in each case based on supporting documentation provided by Trevi, provided that Trevi fully discloses such payment obligations within [**] of the grant of the license. Penwest may elect not to
accept the grant of the license to any such Third Party intellectual property with corresponding payment obligations upon [**] written notice to Trevi from the date of Penwest’s receipt of notification of such payment obligations. 

9.7 Survival. Any expiration or termination of this Agreement will be without prejudice to the rights of either Party against the other
accrued or accruing under this Agreement prior to expiration or termination, including payment obligations arising prior to such expiration or termination. The provisions of Articles VI, VIII, IX, X and XI will survive any expiration or termination
of this Agreement and all other provisions contained in this Agreement that by their explicit terms survive expiration or termination of this Agreement, will survive. Except as set forth in this Article IX, upon termination or expiration of this
Agreement all other rights and obligations of the Parties under this Agreement terminate. 
 ARTICLE X 

DISPUTE RESOLUTION 
 10.1
Referral of Unresolved Matters to Senior Executives. In the event that the Parties are unable to resolve a dispute within [**] from the date such dispute is first brought to the other Party’s attention, the matter shall be referred to
the Chief Executive Officer of Trevi and a senior executive of Penwest or its Affiliate to be resolved by negotiation in good faith as soon as is practicable but in no event later than [**] after referral. 

10.2 Arbitration. Any dispute, controversy or claim arising out of or relating to this Agreement which the Parties have not resolved
under Section 10.1, will be decided by arbitration in accordance with the Rules of the American Arbitration Association for Commercial Arbitration in effect at the time the dispute arises, unless the Parties hereto mutually agree otherwise. To
the extent such rules are inconsistent with this provision, this provision will control. The following rules will apply to any such arbitration: 

(a) Any demand for arbitration must be made in writing to the other Party. 

(b) There will be three arbitrators, one of whom shall be appointed by each Party and a third of whom shall be the chairman of the panel and be
appointed by mutual agreement of the two arbitrators appointed by the Parties. If the two arbitrators cannot agree on the appointment of the third arbitrator within [**], then the AAA shall select the arbitrator. Any arbitration involving patent
rights, other intellectual property rights or intellectual property will be heard by arbitrators who are expert in such areas. 
 (c) The
arbitration will be held in Philadelphia, Pennsylvania, or such other place as the Parties agree. The arbitrators will apply the substantive law of the Commonwealth of Pennsylvania in accordance with Section 11.1, without regard to conflicts of
laws and except that the interpretation and enforcement of this arbitration provision will be governed by the Federal Arbitration Act, 9 U.S.C. Section 1 et. seq. 

  
 22 

 (d) Neither Party will have the right independently to seek recourse from a court of law or other
authorities in lieu of arbitration, but each Party has the right before or during the arbitration to seek and obtain from the appropriate court provisional remedies to avoid irreparable harm, maintain the status quo or preserve the subject matter of
the arbitration. There shall be a stenographic record of the proceedings. The decision of the arbitrators will be final and binding upon both Parties. The arbitrators will render a written opinion setting forth findings of fact and conclusions of
law. 
 (e) Each Party will bear its own expenses of the arbitration, including the expenses of its counsel and other experts, except that
both Parties shall share equally in the cost of appointed arbitrator. 
 10.3 Equitable Relief. Notwithstanding anything to the
contrary, each of the Parties hereby acknowledges that a breach of their respective obligations under this Agreement may cause irreparable harm and that the remedy or remedies at law for any such breach may be inadequate. Each of the Parties hereby
agrees that, in the event of any such breach, in addition to all other available remedies hereunder, the non-breaching Party shall have the right, through the arbitration process described in Section 10.2
or in court, to seek equitable relief to enforce the provisions of this Agreement. 
 ARTICLE XI 

MISCELLANEOUS 
 11.1
Governing Law and Jurisdiction. The validity, construction and performance of this Agreement will be governed by and construed in accordance with the substantive laws of the Commonwealth of Pennsylvania excluding any conflicts or choice of
law rule or principle that might otherwise refer construction or interpretation of this Agreement to the substantive law of another jurisdiction. 

11.2 Force Majeure. Neither Party will be held liable or responsible to the other Party nor be deemed to have defaulted under or
breached this Agreement for failure or delay in fulfilling or performing any term, other than an obligation to make payments hereunder, when such failure or delay is caused by or results from fire, floods, embargoes, government regulations,
prohibitions or interventions, war, acts of war (whether war be declared or not), insurrections, riots, civil commotions, acts of God or any other cause beyond the reasonable control of the affected Party to anticipate, prevent, avoid or mitigate (a
“Force Majeure Event”); provided that (i) the affected Party provides prompt written notice to the other Party of such failure or delay, (ii) the affected Party uses Commercially Reasonable Efforts to mitigate the effects
of the Force Majeure Event, and (iii) the affected Party immediately resumes performance upon cessation of the Force Majeure Event. Notwithstanding the foregoing, any failure or delay in fulfilling a term shall not be considered a result of a
Force Majeure Event if it arises from a failure of Trevi or Penwest to comply with applicable laws. 

  
 23 

 11.3 Further Assurances. Each Party hereto agrees to perform such acts, execute such
further instruments, documents or certificates, and provide such cooperation in proceedings and actions as may be reasonably requested by the other Party in order to carry out the intent and purpose of this Agreement. 

11.4 Notices. Any notice required or permitted to be given under this Agreement will be in writing and will be deemed to have been
properly given if delivered in person by a internationally recognized overnight courier, to the addresses given below or such other addresses as may be designated in writing by the Parties from time to time during the Term. 

In the case of Trevi: 
 Trevi
Therapeutics, Inc. 
 52 Charter Ridge Drive 

Sandy Hook, CT 06482 
 Attention:
Chief Executive Officer 
 With a copy to: 

Stuart Falber, Esq. 
 Wilmer Hale
LLP 
 60 State St. 
 Boston, MA
02109 
 In the case of Penwest: 

Penwest Pharmaceuticals Co. 
 100
Endo Boulevard 
 Chadds Ford, PA 19317 

Attention: Chief Legal Officer 

11.5 Assignment. This Agreement may not be assigned or otherwise transferred by either Party, without the written consent of the other
Party such consent not to be unreasonably withheld, conditioned or delayed; provided, however, that either Party may, without such consent, assign this Agreement, in whole or in part, (i) to any of its Affiliates, and (ii) to a Third Party
successor or purchaser of all or substantially all of its business or assets to which this Agreement relates, whether in a merger, sale of stock, sale of assets or other similar transaction, provided that, (i) the Third Party successor or
purchaser provides written notice to the other Party that such Third Party agrees to be bound by the terms of this Agreement, and (ii) Penwest will not assign this Agreement unless the assignee is also assigned ownership owns or Controls of the
Penwest Patent Rights and Penwest Know-how. Any purported assignment in violation of this Section 11.5 will be void. Any permitted assignee shall assume all obligations of its assignor under this
Agreement. 
 11.6 Affiliate Performance. Any obligation of Trevi under or pursuant to this Agreement may be satisfied, met or
fulfilled, in whole or in part, at Trevi’s sole and exclusive option, either by Trevi directly or by any Affiliate or Sublicensee of Trevi that Trevi causes to satisfy, meet or fulfill such obligation, in whole or in part. 

  
 24 

 11.7 Amendment. The Parties hereto may amend, modify or alter any of the provisions of
this Agreement, but only by a written instrument duly executed by both Parties hereto. 
 11.8 Entire Agreement. This Agreement, along
with all schedules and exhibits attached hereto, contains the entire understanding of the Parties with respect to the subject matter hereof and supersedes all prior agreements, whether written or oral. Each Party confirms that it is not relying on
any representations, warranties or covenants of the other Party except as specifically set out in this Agreement. 
 11.9 No Benefit to
Third Parties. The provisions of this Agreement are for the sole benefit of the Parties and their successors and permitted assigns, and they shall not be construed as conferring any rights in any other Persons. 

11.10 Waiver. The failure of a Party to enforce at any time for any period any of the provisions of this Agreement will not be construed
as a waiver of such provisions or of the rights of such Party thereafter to enforce each such provision. 
 11.11 No Implied Licenses.
Except as expressly and specifically provided under this Agreement, the Parties agree that neither Party is granted any implied rights to or under any of the other Party’s current or future patents, trade secrets, copyrights, moral rights,
trade or service marks, trade dress, or any other intellectual property rights. 
 11.12 Relationship of the Parties. The Parties
agree that their relationship established by this Agreement is that of independent contractors. Furthermore, the Parties agree that this Agreement does not, is not intended to, and shall not be construed to, establish a partnership or joint venture,
and nor shall this Agreement create or establish an employment, agency or any other relationship. Except as may be specifically provided in this Agreement, neither Party shall have any right, power or authority, nor shall they represent themselves
as having any authority to assume, create or incur any expense, liability or obligation, express or implied, on behalf of the other Party, or otherwise act as an agent for the other Party for any purpose. 

11.13 Severability. If any provision of this Agreement is held unenforceable by a court or tribunal of competent jurisdiction in a final
unappealable order because it is invalid or conflicts with any law of any relevant jurisdiction, then such provision will be inoperative in such jurisdiction and the remainder of this Agreement shall remain binding upon the Parties hereto. 

11.14 Interpretation. 
 (a)
General. Unless the context of this Agreement otherwise requires, (a) words of one gender include the other gender; and (b) words using the singular or plural number also include the plural or singular number, respectively. Whenever
this Agreement refers to a number of days, unless otherwise specified, such number shall refer to calendar days. 

  
 25 

 (b) Other Definitional and Agreement References. References to any agreement, contract,
statute, act, or regulation are to that agreement, contract, statute, act, or regulation as amended, modified or supplemented from time to time in accordance with the terms hereof and thereof. 

(c) Capitalization. Any capitalized terms used in any Exhibit or Schedule but not otherwise defined therein, shall have the meaning as
defined in this Agreement. 
 (d) Date References. References from or through any date mean, unless otherwise specified, from and
including or through and including, respectively. 
 (e) Schedules and Exhibits. All Schedules and Exhibits annexed hereto or referred
to herein are hereby incorporated in and made a part of this Agreement as if set forth in full herein. 
 (f) Person References.
References to any Person include the successors and permitted assigns of that Person. 
 (g) References to Parts of this Agreement.
References to Articles, Sections, Schedules, and Exhibits are to Articles, Sections, Schedules, and Exhibits of this Agreement unless otherwise specified. 

(h) Other Definitional and Interpretative Provisions. The words “hereof”, “herein” and “hereunder” and
words of like import used in this Agreement shall refer to this Agreement as a whole and not to any particular provision of this Agreement. Whenever the words “include”, “includes” or “including” are used in this
Agreement, they shall be deemed to be followed by the words “without limitation”, whether or not they are in fact followed by those words or words of like import. The word “or” is used in the inclusive sense (and/or).
Writing”, “written” and comparable terms refer to printing, typing and other means of reproducing words (including electronic media) in a visible form. 

(i) Headings. The Article and Section headings contained in this Agreement are for reference purposes only and shall not affect in any
way the meaning or interpretation of this Agreement. 
 (j) Expenses. Except as otherwise expressly provided in this Agreement, each
Party shall pay the fees and expenses of its respective lawyers and other experts and all other expenses and costs incurred by such Party incidental to the negotiation, preparation, execution and delivery of this Agreement. 

11.15 Counterparts. This Agreement may be executed in any number of counterparts (including by facsimile), each of which shall be deemed
an original, but all of which together shall constitute one and the same document. 
 [Signature Page Follows] 

  
 26 

 IN WITNESS WHEREOF, Trevi and Penwest have caused this Agreement to be duly executed by their
authorized representatives under seal, in duplicate on the Effective Date. 
  

			
	Trevi Therapeutics, Inc.
		
	By:	 	 /s/ Jennifer Good

		 	Jennifer Good
		 	Chief Executive Officer
	
	Penwest Pharmaceuticals Co.
		
	By:	 	 /s/ David P. Holveck

	Name:	 	David P. Holveck
	Title:	 	President and Chief Executive Officer

 Exhibit A 

Description of Nalbuphine HCL and Nalbuphine Drug Product 

Drug Substance 
  

	1.	 Drug Substance 

The nalbuphine HCl drug substance is a [**]. Nalbuphine HCl is a [**] 
  

	2.	 Description and Composition of the Drug Product 

Nalbuphine HCl ER tablets, [**]. Nalbuphine HCl ER tablets [**]. 
  

	2.1	 Composition 

[**]. 

 Exhibit B 

Existing Inventory of API 

Approximately [**] of nalbuphine hydrochloride drug substance 

 Exhibit C 

Pending Patent Applications 

Nalbuphine 
  

											
	 Country
	  	 Status
	  	 Title
	  	 App #
	  	 App Date
	  	 Owner

	 [**]
	  	 [**]
	  	 [**]
	  	 [**]
	  	 [**]
	  	 [**]

	 [**]
	  	 [**]
	  	 [**]
	  	 [**]
	  	 [**]
	  	 [**]

	 [**]
	  	 [**]
	  	 [**]
	  	 [**]
	  	 [**]
	  	 [**]

	 [**]
	  	 [**]
	  	 [**]
	  	 [**]
	  	 [**]
	  	 [**]

 Exhibit D 

Technology Transfer Plan 
 Penwest
to provide to Trevi, in accordance with the delivery instructions provided by Trevi, the following archived documents and materials within [**] of the Effective Date, to the extent such documents are contained in the boxes specifically designated
for the retention of such documents and in the current possession of Penwest. 
 Soft Files 

All readily identifiable electronic data for nalbuphine as stored on the Penwest T: and S: drives 

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. A total of 6 pages were omitted. [**] 

 Exhibit E 

Letters to FDA transferring INDs 
 Endo
Pharmaceuticals Letterhead 
 May XX, 2011 
 Bob Rappaport,
MD, Director 
 Division of Anesthesia and Analgesia Products 

Food and Drug Administration 
 Center for Drug Evaluation and
Research 
 Central Document Room 
 5901-B Ammendale Rd. 
 Beltsville, MD 20705-1266 

SUBMITTED IN TRIPLICATE 
 RE:
    IND [**] 
 Nalbuphine Hydrochloride Extended Release Tablets 

Transfer of IND Sponsorship, 
 IND Serial Number: [**] 

Dear Dr. Rappaport: 
 Reference is made to the
Investigational New Drug Application (IND) cited above. Penwest Pharmaceuticals Co., a wholly-owned subsidiary of Endo Pharmaceuticals, hereby transfers sponsorship of IND [**] to: 

Trevi Therapeutics, Inc. 
 [**] 

All rights to IND [**] have been transferred to Trevi Therapeutics, Inc. 

The last clinical study conducted under this IND completed in [**]. There are no active investigations at this time. All IND documentation has been sent to
Trevi Therapeutics, Inc. 
 We understand that the subject IND and all information contained herein, unless otherwise made public by Endo Pharmaceuticals,
is CONFIDENTIAL. 
 If you require further assistance, please contact Robert Barto, Vice President of Regulatory Affairs at (484) 840-4262. 

	
	 Sincerely,
  

	Robert Barto Vice President, Regulatory Affairs
	 Endo Pharmaceuticals Inc.
 100 Endo
Boulevard

	Chadds Ford, PA 19317
	Telephone: (484) 840-4262

 CC: Thomas Sciascia, MD, Executive Vice President, Research and Development, Trevi Therapeutics 

Enclosures: FDA Form 1571, Transfer of Sponsorship Letter (1 archival copy and 2 review copies) 

 Trevi Therapeutics Letterhead 

May XX, 2011 
 Bob Rappaport, MD, Director 

Division of Anesthesia and Analgesia Products 
 Food and Drug
Administration 
 Center for Drug Evaluation and Research 

Central Document Room 

5901-B Ammendale Rd. 

Beltsville, MD 20705-1266 
 SUBMITTED IN TRIPLICATE

 RE:     IND [**], Nalbuphine Hydrochloride Extended Release Tablets 

Acceptance of IND Sponsorship 
 IND Serial No.: XXXX 

Dear Dr. Rappaport: 
 Reference is made to the
Investigational New Drug Application (IND) cited above. Reference is also made to the transfer letter from Penwest Pharmaceuticals sent May XXX, 2011 (Serial No. XXX). Trevi Therapeutics, Inc. hereby accepts sponsorship of IND [**] effective May XX,
2011. All pertinent Regulations will be followed with respect to this IND application. 
 Trevi Therapeutics, Inc. commits to the previous agreements,
commitments, and conditions made by the former owner and contained in the IND application. 
 Trevi Therapeutics, Inc., has received and will maintain a
complete copy of the IND, including amendments and records that are required to be kept. 
 If you require further assistance, please contact Thomas
Sciascia, MD at [**]. 
  

	
	 Sincerely,
  

	Thomas Sciascia, MD
	Executive Vice President, Research and Development
	Trevi Therapeutics, Inc.
	[**]
	Telephone: [**]
	Fax: (617) YYY-ZZZ
	
	CC: Robert Barto, Vice President Regulatory Affairs

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