Document:

Amendment to Offer Letter - William C. Houghton

 Exhibit 10.78 
 March 24, 2009 
 William Houghton, M.D. 
 Dear
Bill, 
 Anesiva, Inc. (the “Company”) is pleased to offer you an amendment to your employment terms, as set forth in the offer
letter between you and the Company, dated July 9, 2008 (the “Offer Letter” attached hereto as Exhibit A). The employment terms set forth in this Amendment are effective as of April 1, 2009 (the “Amendment Date”)
unless stated otherwise. Unless this Amendment specifically states that it supersedes an employment term in the Offer Letter, the employment terms of the Offer Letter shall remain binding and in full force and effect. 
 1. Relocation Benefits. In order to assist you with your relocation, the Company will do the following: 
  

	 	•	 	 Pay you $4,000 per month ($2,000 semi-monthly) to rent temporary housing in the San Francisco Bay Area for one year from your Employment Commencement Date
(“Housing Allowance”). Upon a Change of Control, as defined in the Company’s Amended and Restated Executive Change in Control and Severance Benefit Plan dated January 20, 2009, or involuntary termination, the payments for the
remaining months of the one (1) year term will be accelerated. The Housing Allowance payments will be paid in accordance with the Company’s standard payroll schedule and will be subject to reduction to reflect applicable withholding and
payroll taxes and other deductions required by law. 

  

	 	•	 	 Reimburse you or pay on your behalf up to $5,000 for reasonable hotel, airfare, and rental car expenses for three (3) months after April 1, 2009
for travel for you and your wife between Texas and the San Francisco Bay Area consistent with the Company’s travel policy or otherwise pre-approved by the Company (“Travel Expenses”). 

 2. Employment Relationship. Your employment with the Company is and continues to be “at will,” as described in paragraph 12 of
the Offer Letter 
 3. Supersedes. This Amendment supersedes and replaces any prior agreements, representations or
understandings, whether written, oral or implied, between you and the Company regarding the employment terms described in this Amendment, provided that unless specifically superseded, the original employment terms of the Offer Letter remain in full
force and effect. 
  

			
	Very truly yours,
	
	ANESIVA, INC.
		
	By:	 	/s/ John Tran
		 	John Tran
		 	VP, Finance & Chief Accounting Officer

 I have read, and accept and agree to, this letter agreement: 
  

	
	/s/ William Houghton
	Signature of William Houghton, M.D.

 Dated: 03/24/2009 
 cc: Michael KrandaAmendment to Offer Letter - William C. Houghton

 Exhibit 10.79 
 

 
 November 17, 2008 
 William
C. Houghton 
 Dear Bill: 
 Anesiva, Inc. (the
“Company”) is pleased to offer you an amendment (the “Amendment”) to your employment terms, as set forth in the offer letter between you and the Company, dated July 9, 2008 (the “Offer Letter”). The employment
terms set forth in this Amendment are effective as of November 17, 2008 (the “Amendment Date”). Unless this Amendment specifically states that it supersedes a term in the Offer Letter, the terms of the Offer Letter shall remain
binding and in full force and effect. 
 1. Retention Bonus. You will be eligible to receive a Retention Bonus in an amount equal to
two (2) months of your base salary currently in effect, to be earned and payable on the following schedule: (i) 50% of the bonus on November 17, 2008, (ii) 25% of the bonus on November 26, 2008, and (iii) 25% of the
bonus on December 15, 2008. 
 In the event that you resign from employment with the Company for any reason before February 9,
2009, you agree that you will repay to the Company this Retention Bonus amount paid to you (“Retention Repayment Amount”) pursuant to this Section. Any Retention Repayment Amount that must be repaid pursuant to this paragraph will be paid
within thirty (30) days following your last date of employment with the Company. 
 In the event that you are involuntarily terminated
from employment with the Company, you will not be liable for repayment of the Retention Bonus. 
 2. Employment Relationship.
Your employment with the Company is and continues to be “at will” as described in Section 12 of your Offer Letter. 
 3.
Supersedes. This Amendment supersedes and replaces any prior agreements, representations or understandings, whether written, oral or implied, between you and the Company regarding this subject matter described herein, provided that unless
specifically superseded by this Amendment, the terms of the Offer Letter remain in full force and effect. 
 We hope that you find the
forgoing terms acceptable. You may indicate your agreement with these terms and accept this Amendment by signing and dating the Amendment and returning it to me. 
  

			
	Very truly yours,
	
	ANESIVA, INC.
		
	By:	 	/s/ Jean-Frederic Viret
		 	 Jean-Frederic Viret
 Vice President & Chief
Financial Officer

 I have read, and accept and agree to, the terms of this Amendment to my Offer Letter: 
  

	
	/s/ William C. Houghton
	William C. Houghton

 Dated: 11-19-08Offer Letter Agreement - John H. Tran

 Exhibit 10.80 
 March 23, 2009 
 John Tran 
 Dear John:

 In connection with your appointment to the position of “Chief Accounting Officer” of Anesiva, Inc. (“we” or the
“Company”), we are pleased to offer you the following employment terms. The most important component of any successful company is its people. To successfully accomplish our goals, we are assembling a world-class team to support our
development, manufacturing and commercialization efforts. 
 The employment terms set forth in this offer letter are effective as of
February 19, 2009 (the “Offer Date”) unless stated otherwise. This offer letter supersedes all other agreements, arrangements and understandings between you and the Company, except those terms which are precluded by law, specifically,
previous grants of stock options and already earned bonuses which shall remain binding and in full force and effect. 
 1.
Position. Your title will be Vice President, Finance & Chief Accounting Officer, and you will report to Michael L. Kranda, President and Chief Executive Officer. This is a full-time exempt position. You will work at our facility
located at 650 Gateway Boulevard, South San Francisco, CA, 94080. 
 2.
Salary. Effective and retroactive to February 19, 2009, your gross semi-monthly base salary will be $9,375 (equivalent to an annualized rate of $225,000 per year). Your salary will subject to adjustment pursuant to the
Company’s employment compensation policies as in effect and revised from time to time and will be payable in accordance with the Company’s standard payroll schedule. Employees are currently paid on the 15th and the last day of the month. 
 3. Discretionary
Bonus. You will be eligible to earn an annual target bonus of thirty percent (30%) of your base salary earned during the bonus period for fiscal year 2009. Whether your annual bonus is earned, and the amount of the annual bonus
(if any), will be determined under the terms of the Company’s annual bonus program (as adopted by the Compensation Committee of the Board). The Board will determine, in its sole discretion, the applicable corporate performance targets for each
bonus year, which may include corporate financial goals, business development goals, and preclinical and clinical development goals. In order to be eligible to earn your annual bonus, you must remain an active employee of the Company through the
bonus payout date following the end of the applicable work year, and you will not earn any of your annual bonus if your employment terminates for any reason before the bonus payout date. The Company shall have the discretion to structure some or all
of your annual bonus so that it qualifies as “performance-based compensation” within the meaning of Section 162(m) of the Internal Revenue Code of 1986, as amended (the “Code”). 
 4. Stock Option. In connection with your appointment, you will be granted an option to purchase 50,000 shares of the Company’s Common
Stock by the Company’s compensation committee and board of directors during the next regularly scheduled compensation committee meeting. The exercise price per share is equal to the fair market value per share on the date the option is granted.
The option is subject to the terms and conditions applicable to options granted under the Company’s 2003 Equity Incentive Plan (the “Plan”), as described in the Plan and the applicable Stock Option Agreement. You will vest in equal
monthly installments over the next forty-eight (48) months of continuous service, as described in the applicable Stock Option Agreement. 
 5. Change in Control. You will be entitled to the benefits provided in the Company’s Amended and Restated Executive Change in Control and Severance Benefit Plan (the “Plan”), a copy of which is enclosed, in the
event of a Change in Control as defined in the Plan. 
 6. Employment Relationship. Employment with the Company is for no
specific period of time. Your employment with the Company will be “at will,” meaning that either you or the Company may terminate your employment at any time and for any reason, with or without cause. Although your job duties, title,
compensation and benefits, as well as the Company’s personnel policies and procedures, may change from time to time, the “at will” nature of your employment may only be changed in an express written agreement signed by you and the
Chief Executive Officer of the Company. 
 7. Outside Activities. While you render services to the Company, you agree that you
will not engage in any other employment, consulting or other business activity without the prior written consent of the Company. While you render services to the Company you also will not assist any person or entity in competing with the Company or
in preparing to compete with the Company. In addition, while you render services to the Company and for one (1) year thereafter, you will not engage in, and will not assist any person or entity in, soliciting, recruiting, or hiring away from
the Company any employees or consultants of the Company. 

 8. Withholding Taxes. All forms of compensation referred to in this letter agreement are
subject to reduction to reflect applicable withholding and payroll taxes and other deductions required by law. Enclosed, for your reference, is the W-4 tax withholding form that you will be required to complete on your first day of employment.

 9. Arbitration. You and the Company agree to waive any rights to a trial before a judge or jury and agree to arbitrate
before a neutral arbitrator any and all claims or disputes arising out of this letter agreement and any and all claims arising from or relating to your employment with the Company, including (but not limited to) claims against any current or former
employee, director or agent of the Company, claims of wrongful termination, retaliation, discrimination, harassment, breach of contract, breach of the covenant of good faith and fair dealing, defamation, invasion of privacy, fraud,
misrepresentation, constructive discharge or failure to provide a leave of absence, or claims regarding commissions, stock options or bonuses, infliction of emotional distress or unfair business practices. 
 The arbitrator’s decision must be written and must include the findings of fact and law that support the decision. The arbitrator’s decision
will be final and binding on both parties, except to the extent applicable law allows for judicial review of arbitration awards. The arbitrator may award any remedies that would otherwise be available to the parties if they were to bring the dispute
in court. The arbitration will be conducted in accordance with the National Rules for the Resolution of Employment Disputes of the American Arbitration Association; provided, however that the arbitrator must allow the discovery authorized by the
California Arbitration Act or the discovery that the arbitrator deems necessary for the parties to vindicate their respective claims or defenses. The arbitration will take place in San Mateo County or, at your option, the county in which you
primarily worked with the Company at the time when the arbitrable dispute or claim first arose. 
 You and the Company will share the costs
of arbitration equally, except that the Company will bear the cost of the arbitrator’s fee and any other type of expense or cost that you would not be required to bear if you were to bring the dispute or claim in court. Both the Company and you
will be responsible for their own attorneys’ fees, and the arbitrator may not award attorneys’ fees unless a statute or contract at issue specifically authorizes such an award. 
 The foregoing notwithstanding, this arbitration provision does not apply to workers’ compensation or unemployment insurance claims. 
 If an arbitrator or court of competent jurisdiction (the “Neutral”) determines that any provision of this arbitration provision is illegal or
unenforceable, then the Neutral shall modify or replace the language of this arbitration provision with a valid and enforceable provision, but only to the minimum extent necessary to render this arbitration provision legal and enforceable.

 10. Entire Agreement. This letter agreement, together with the Employee Proprietary Information and Inventions Agreement,
supersedes and replaces any prior agreements, representations or understandings, whether written, oral or implied, between you and the Company, except as specified in this offer letter. 
 We hope that find the foregoing terms acceptable and look forward to your valuable contributions to Anesiva as Chief Accounting Officer. You may indicate
your agreement with these terms and accept this Amendment by signing and dating the Amendment and returning it to me. 
  

			
	Very truly yours,
	
	ANESIVA, INC.
		
	By:	 	/s/ Michael Kranda
		 	Michael Kranda
		 	President and Chief Executive Officer

 I have read, accept and agree to the terms of this Offer Letter: 
  

	
	/s/ John H. Tran
	Signature of John H. Tran

 Dated: 03/23/2009

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