Document:

EX-10.1

 Exhibit 10.1 

FIFTH AMENDMENT TO 
 PUMA
BIOTECHNOLOGY, INC. 
 2011 INCENTIVE AWARD PLAN 

This Fifth Amendment (“Fifth Amendment”) to the Puma Biotechnology, Inc. 2011 Incentive Award Plan, as amended (the
“Plan”), is adopted by the Board of Directors (the “Board”) of Puma Biotechnology, Inc., a Delaware corporation (the “Company”), effective as of April 1, 2021 (the “Effective
Date”). Capitalized terms used in this Fifth Amendment and not otherwise defined herein shall have the meanings ascribed to such terms in the Plan. 

RECITALS 
  

	A.	 The Company currently maintains the Plan. 

 

	B.	 Pursuant to Section 13.1 of the Plan, (i) the Board has the authority to amend the Plan at any time
or from time to time, and (ii) the Board has the authority to amend the Plan to increase the limits imposed in Section 3.1 on the maximum number of shares which may be issued under the Plan (the “Share Limit”), subject to
approval by the stockholders of the Company twelve (12) months before or after such action. 

  

	C.	 The Board believes it is in the best interests of the Company and its stockholders to amend the Plan to
(i) extend the period under which incentive stock options may be granted under the Plan and (ii) increase the Share Limit. 

AMENDMENT 
 The Plan is
hereby amended as follows, effective as of the Effective Date, except as otherwise provided below: 
  

	 	1.	 Section 2.19. Section 2.19 is hereby deleted and replaced in its entirety
with the following: 

 “2.19 “Effective Date” shall mean April 1, 2021.” 

 

	 	2.	 Section 3.1(a). The first sentence of Section 3.1(a) of the Plan is
hereby deleted and replaced in its entirety with the following, subject to approval by the stockholders of the Company within twelve (12) months following the Effective Date: 

“Subject to Sections 3.1(b), 13.1 and 13.2 hereof, the aggregate number of Shares which may be issued or transferred pursuant to Awards
under the Plan shall be equal to fourteen million five hundred twenty-nine thousand four hundred twelve (14,529,412) Shares (the “Share Limit”), all of which may be issued as Incentive Stock Options.” 

 

	 	3.	 This Fifth Amendment shall be and, as of the Effective Date, is hereby incorporated in and forms a part of the
Plan; provided that the amendments to Section 2.19 and Section 3.1(a) shall be subject to approval by the stockholders of the Company within twelve (12) months of the Effective Date. 

 

	 	4.	 Except as expressly provided herein, all terms and conditions of the Plan shall remain in full force and
effect. 

 ***** 

 I hereby certify that this Fifth Amendment was duly adopted by the Board on April 1,
2021. 
 ***** 
 I hereby
certify that this Fifth Amendment was approved by the stockholders of the Company on June 15, 2021. 
 Executed on this 15th day of
June, 2021. 
  

			
	PUMA BIOTECHNOLOGY, INC.
		
	By:	 	 /s/ Alan H. Auerbach

	Name:	 	Alan H. Auerbach
	Title:	 	President, Chief Executive OfficerExhibit
10.5

 

THIS
PROMISSORY NOTE (“NOTE”) HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”).
THIS NOTE HAS BEEN ACQUIRED FOR INVESTMENT ONLY AND MAY NOT BE SOLD, TRANSFERRED OR ASSIGNED IN THE ABSENCE OF REGISTRATION OF THE RESALE
THEREOF UNDER THE SECURITIES ACT OR AN OPINION OF COUNSEL REASONABLY SATISFACTORY IN FORM, SCOPE AND SUBSTANCE TO THE COMPANY THAT SUCH
REGISTRATION IS NOT REQUIRED.

 

PROMISSORY
NOTE

 

	Principal
    Amount: Up to $300,000	Dated
    as of March 22, 2021

 

Pono
Capital Corp, a Delaware corporation and blank check company (the “Maker”), promises to pay to the order of Mehana
Equity LLC or its registered assigns or successors in interest (the “Payee”), or order, the principal sum of up to
Three Hundred Thousand Dollars ($300,000) in lawful money of the United States of America (the “Borrowing Limit”),
on the terms and conditions described below. All payments on this Note shall be made by check or wire transfer of immediately available
funds or as otherwise determined by the Maker to such account as the Payee may from time to time designate by written notice in accordance
with the provisions of this Note.

 

1.
Principal. The principal balance of this Note shall be payable by the Maker on the earlier of: (i) July 31, 2021 or (ii) the date
on which Maker consummates an Initial Public Offering of its securities. The principal balance may be prepaid at any time. Under no circumstances
shall any individual, including but not limited to any officer, director, employee or shareholder of the Maker, be obligated personally
for any obligations or liabilities of the Maker hereunder. As used herein, “Initial Public Offering” or “IPO”
shall mean the closing of the issuance and sale of shares of Common Stock of the Maker in the Maker’s first underwritten public
offering pursuant to an effective registration statement under the Securities Act.

 

2.
Interest. No interest shall accrue on the unpaid principal balance of this Note.

 

3.
Drawdown Requests. Maker and Payee agree that Maker may request up to Three Hundred Thousand Dollars ($300,000) for costs reasonably
related to Maker’s Initial Public Offering of its securities. The principal of this Note may be drawn down from time to time prior
to the earlier of: (i) July 31, 2021 or (ii) the date on which Maker consummates an Initial Public Offering of its securities, upon written
request from Maker to Payee (each, a “Drawdown Request”). Each Drawdown Request must state the amount to be drawn
down, and must not be for an amount less than Five Thousand Dollars ($5,000) unless agreed upon by Maker and Payee. Payee shall fund
each Drawdown Request no later than five (5) business days after receipt of a Drawdown Request; provided, however, that the maximum amount
of drawdowns collectively under this Note is the Borrowing Limit. Once an amount is drawn down under this Note, it shall not be available
for future Drawdown Requests even if prepaid. No fees, payments or other amounts shall be due to Payee in connection with, or as a result
of, any Drawdown Request by Maker.

 

4.
Application of Payments. All payments shall be applied first to payment in full of any costs incurred in the collection of any sum
due under this Note, including (without limitation) reasonable attorney’s fees, then to the payment in full of any late charges
and finally to the reduction of the unpaid principal balance of this Note.

 

5.
Events of Default. The following shall constitute an event of default (“Event of Default”):

 

	(a)	Failure
                                            to Make Required Payments. Failure by Maker to pay the principal amount due pursuant
                                            to this Note within five (5) business days of the date specified above.
	 	 
	(b)	Voluntary
                                            Bankruptcy, Etc. The commencement by Maker of a voluntary case under any applicable bankruptcy,
                                            insolvency, reorganization, rehabilitation or other similar law, or the consent by it to
                                            the appointment of or taking possession by a receiver, liquidator, assignee, trustee, custodian,
                                            sequestrator (or other similar official) of Maker or for any substantial part of its property,
                                            or the making by it of any assignment for the benefit of creditors, or the failure of Maker
                                            generally to pay its debts as such debts become due, or the taking of corporate action by
                                            Maker in furtherance of any of the foregoing.

 

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	(c)	Involuntary
                                            Bankruptcy, Etc. The entry of a decree or order for relief by a court having jurisdiction
                                            in the premises in respect of Maker in an involuntary case under any applicable bankruptcy,
                                            insolvency or other similar law, or appointing a receiver, liquidator, assignee, custodian,
                                            trustee, sequestrator (or similar official) of Maker or for any substantial part of its property,
                                            or ordering the winding-up or liquidation of its affairs, and the continuance of any such
                                            decree or order unstayed and in effect for a period of 60 consecutive days.

 

6.
Remedies.

 

	(a)	Upon
                                            the occurrence of an Event of Default specified in Section 5(a) hereof, Payee may, by written
                                            notice to Maker, declare this Note to be due immediately and payable, whereupon the unpaid
                                            principal amount of this Note, and all other amounts payable hereunder, shall become immediately
                                            due and payable without presentment, demand, protest or other notice of any kind, all of
                                            which are hereby expressly waived, anything contained herein or in the documents evidencing
                                            the same to the contrary notwithstanding.
	 	 
	(b)	Upon
                                            the occurrence of an Event of Default specified in Sections 5(b) and 5(c), the unpaid principal
                                            balance of this Note, and all other sums payable with regard to this Note, shall automatically
                                            and immediately become due and payable, in all cases without any action on the part of Payee.

 

7.
Waivers. Maker and all endorsers and guarantors of, and sureties for, this Note waive presentment for payment, demand, notice of
dishonor, protest, and notice of protest with regard to the Note, all errors, defects and imperfections in any proceedings instituted
by Payee under the terms of this Note, and all benefits that might accrue to Maker by virtue of any present or future laws exempting
any property, real or personal, or any part of the proceeds arising from any sale of any such property, from attachment, levy or sale
under execution, or providing for any stay of execution, exemption from civil process, or extension of time for payment; and Maker agrees
that any real estate that may be levied upon pursuant to a judgment obtained by virtue hereof or any writ of execution issued hereon,
may be sold upon any such writ in whole or in part in any order desired by Payee.

 

8.
Unconditional Liability. Maker hereby waives all notices in connection with the delivery, acceptance, performance, default, or enforcement
of the payment of this Note, and agrees that its liability shall be unconditional, without regard to the liability of any other party,
and shall not be affected in any manner by any indulgence, extension of time, renewal, waiver or modification granted or consented to
by Payee, and consents to any and all extensions of time, renewals, waivers, or modifications that may be granted by Payee with respect
to the payment or other provisions of this Note, and agrees that additional makers, endorsers, guarantors, or sureties may become parties
hereto without notice to Maker or affecting Maker’s liability hereunder.

 

9.
Notices. All notices, statements or other documents which are required or contemplated by this Note shall be made in writing and
delivered: (i) personally or sent by first class registered or certified mail, overnight courier service or facsimile or electronic transmission
to the address designated in writing, (ii) by facsimile to the number most recently provided to such party or such other address or fax
number as may be designated in writing by such party or (iii) by electronic mail, to the electronic mail address most recently provided
to such party or such other electronic mail address as may be designated in writing by such party. Any notice or other communication
so transmitted shall be deemed to have been given on the day of delivery, if delivered personally, on the business day following receipt
of written confirmation, if sent by facsimile or electronic transmission, one (1) business day after delivery to an overnight courier
service or five (5) days after mailing if sent by mail.

 

10.
Construction. This note shall be construed and enforced in accordance with the laws of Delaware, without regard to conflict of law
provisions thereof.

 

11.
Severability. Any provision contained in this Note which is prohibited or unenforceable in any jurisdiction shall, as to such jurisdiction,
be ineffective to the extent of such prohibition or unenforceability without invalidating the remaining provisions hereof, and any such
prohibition or unenforceability in any jurisdiction shall not invalidate or render unenforceable such provision in any other jurisdiction.

 

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12.
Trust Waiver. Notwithstanding anything herein to the contrary, the Payee hereby waives any and all right, title, interest or claim
of any kind (“Claim”) in or to any distribution of or from the trust account to be established in which the proceeds
of the Initial Public Offering to be conducted by the Maker (including the deferred underwriters discounts and commissions) and the proceeds
of the sale of the warrants to be issued in a private placement to occur prior to the closing of the IPO are to be deposited, as described
in greater detail in the registration statement and prospectus to be filed with the Securities and Exchange Commission in connection
with the IPO, and hereby agrees not to seek recourse, reimbursement, payment or satisfaction for any Claim against the trust account
for any reason whatsoever.

 

13.
Amendment; Waiver. Any amendment hereto or waiver of any provision hereof may be made with, and only with, the written consent of
the Maker and the Payee.

 

14.
Assignment. No assignment or transfer of this Note or any rights or obligations hereunder may be made by any party hereto (by operation
of law or otherwise) without the prior written consent of the other party hereto and any attempted assignment without the required consent
shall be void.

 

[Signature
page follows]

 

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IN
WITNESS WHEREOF, Maker, intending to be legally bound hereby, has caused this Note to be duly executed by the undersigned as of the
day and year first above written.

 

	 	Pono
    Capital Corp
	 	 
	 	By:	/s/
    Dustin Shindo
	 	Name:	Dustin
    Shindo
	 	Title:
    	Chief
    Executive Officer

 

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