Document:

EX-10.1

 Exhibit 10.1 
  

 
 RULES OF THE 

NuCana BioMed Limited 

SHARE OPTION SCHEME (INCLUDING ENTERPRISE 

MANAGEMENT INCENTIVES) 
  

 
 Approved and Adopted by the
Board of NuCana BioMed Ltd 
 On 1st August 2009 

and 
 Amended and
approved by the Board of NuCana BioMed Limited and its shareholders 
 on 15 & 17 November 2011 

 CONTENTS 
  

							
	1.	  	INTERPRETATION	  	 	1	 
	2.	  	PROVISIONS RELATING TO THE GRANT OF OPTIONS	  	 	6	 
	3.	  	LIMITS AND OTHER RESTRICTIONS OF THE SCHEME RULES	  	 	8	 
	4.	  	NON-ASSIGNABILITY OF OPTIONS	  	 	9	 
	5.	  	EXERCISE CONDITIONS	  	 	9	 
	6.	  	EXERCISE OF OPTION	  	 	9	 
	7.	  	DEATH OF OPTION HOLDER	  	 	11	 
	8.	  	CHANGE OF CONTROL, AND SALE OF THE COMPANY	  	 	11	 
	9.	  	WINDING-UP OF THE COMPANY	  	 	13	 
	10.	  	VARIATION OF CAPITAL	  	 	14	 
	11.	  	ALTERATIONS TO THE RULES	  	 	15	 
	12.	  	MISCELLANEOUS	  	 	15	 
	13.	  	GOVERNING LAW	  	 	16	 

 NuCana Biomed Limited 

SHARE OPTION SCHEME 

RULES 
 (INCLUDING
ENTERPRISE MANAGEMENT INCENTIVES) 
  

	1.	INTERPRETATION 

  

	1.1	In these Rules (unless the context otherwise requires) the following words and expressions shall have the following meanings: 

  

			
	“Admission”	  	the admission of part of or the entire issued share capital of the Company (or any holding company of the Company) to listing on the Official List of the UK Listing Authority and to trading on the market for listed securities of
London Stock Exchange plc, or to trading on AIM or to trading on any recognised investment exchange (as that term is defined in S841 ICTA)
		
	“Adoption Date”	  	the date on which the Scheme is adopted by the Board/Company;
		
	“AIM”	  	the market of that name operated by the London Stock Exchange Plc;
		
	“Any Other EMI Scheme”	  	any scheme (other than the Scheme) adopted by the Company or any Group Member or by the Board which provides for the grant of options to acquire Shares which are Qualifying Options;
		
	“Any Other Scheme”	  	any scheme (other than the Scheme) approved by the Company in general meeting or adopted by the Board which provides for the acquisition of Shares by or on behalf of employees or directors of the Group;
		
	“Appropriate Period”	  	as defined in Rule 8.3;
		
	“Associated Company”	  	has the meaning given to that expression by Section 416 ICTA;

  
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	“Auditors”	  	the auditors for the time being of the Company (acting as experts and not as arbitrators);
		
	“Board”	  	the board of directors for the time being of the Company or a committee thereof duly authorised for the purposes of the Scheme;
		
	“Capital”	  	issued ordinary share capital of the Company;
		
	“Close Period”	  	any period where there are restrictions on dealing in the shares as stipulated by a relevant authority including under the rules of AIM;
		
	“Company”	  	NuCana BioMed Limited registered in the UK with registration number 03308778 and whose registered address is Butler & Co Accountants, 5 Southwell Park Road, Camberley, Surrey, GU15 3PU;
		
	“Control”	  	has the meaning given to it by Section 840 ICTA and “Controlled” shall have a similar meaning;
		
	“Date of Grant”	  	the date on which an Option was or is to be granted under Rule 2;
		
	“Eligible Employee”	  	An employee or director of the Company or of a Qualifying Subsidiary and additionally, in the case of an Option which is to be granted as an EMI Option, a person who also satisfies the requirements of paragraphs 25 and 26 of
Schedule 5, and whose average amount per week of reckonable time in relevant employment (as defined in Section 535(3) ITEPA and paragraph 26 Schedule 5) during a tax year is not less than 25 hours a week or such other relevant statutory
threshold (provided that where the Board approves the grant of Unapproved Options to a person who has provided services to the Company and who does not satisfy the foregoing definition such person shall be deemed to be an Eligible Employee for the
purposes of these Rules and such grant of Unapproved Options shall be binding);

  
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	“EMI Code”	  	the provisions set out in Sections 527 to 541 ITEPA (inclusive), Schedule 5 and Part 4 Schedule 7D TCGA;
		
	“EMI Option”	  	a right (for the time being subsisting) to acquire Shares under the Scheme in accordance with these Rules and which is a Qualifying Option;
		
	“Exercise Conditions”	  	conditions, if any, determined by the Board at the Date of Grant and as set out in the Appendix of the Option Agreement required to be satisfied before the Option can be exercised, such conditions being subject to the provisions set
out in Rule 5;
		
	“FSMA”	  	the Financial Services and Markets Act 2000;
		
	“Group”	  	the Company and its Subsidiaries and “Group Member” shall be construed accordingly;
		
	“HMRC”	  	HM Revenue and Customs;
		
	“ICTA”	  	the Income and Corporation Taxes Act 1988;
		
	“ITEPA”	  	the Income Tax (Earnings and Pensions) Act 2003;
		
	“Joint Election”	  	means a joint election pursuant to Sections 425, 430 or 431 ITEPA;
		
	“Letter of Invitation”	  	a letter substantially in the form set out in schedule 1 to these Rules provided by the Company to an employee inviting him to accept the grant of an Option;
		
	“Market Value”	  	 has the same meaning as it has for the purposes of Part VIII TCGA and which shall be deemed to be:

 
 (a)    the middle market
quotation of a Share as decided from the Official List for the dealing day immediately preceding the Date of Grant; or

  
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		  	 (b)    (if the Shares are not for the time being so quoted) the price
determined by the Board, as being the market value of a Share on the day prior to the day on which the Option in question is granted
  

		  	 and, for an EMI Option agreed by Shares Valuation at HMRC;

		
	“Material Interest”	  	means an interest in the Company as set out in paragraph 29 of Schedule 5;
		
	“NIC”	  	national insurance contributions;
		
	“Notice of Exercise”	  	a notice of exercise substantially in the form set out in the Appendix to the Option Agreement;
		
	“Notice of Grant”	  	 in the case of Options which are to be EMI Options, a notification to HMRC to be jointly signed by

 
 (a)    the employer company
of the Option Holder and
  

(b)    the Option Holder
  

in such form required by HMRC from time to time;

		
	“Official List”	  	the official listing as referred to in Part VI FSMA;
		
	“Option”	  	an option to acquire Shares granted under these Rules, whether an EMI Option or an Unapproved Option;
		
	“Option Agreement”	  	a written agreement between the Company and the Option Holder in the form of a deed substantially in the form set out in schedule 2 to these Rules and if it is an EMI Option containing the information required by Schedule
5;
		
	“Option Holder”	  	a person who holds an Option or (where the context admits) his personal representatives;

  
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	“Option Price”	  	the price at which each Share may be acquired on the exercise of an Option determined by the Board at the Date of Grant being not substantially less than the Market Value and, subject to Rule 10, not less than the nominal value of
the Share where the Shares are to be acquired by direct issue from the Company;
		
	“Qualifying Option”	  	an option which at the time of grant meets the requirements of Schedule 5 and in respect of which a Notice of Grant is executed;
		
	“Qualifying Subsidiary”	  	has the meaning given in paragraph 11 of Schedule 5;
		
	“Redundancy”	  	termination of employment by reason of redundancy in accordance with Section 139 Employment Rights Act 1996;
		
	“Relevant CSOP Option”	  	an option to acquire shares under a scheme approved pursuant to the provisions of Schedule 4 ITEPA;
		
	“Rules”	  	these rules of the Scheme as from time to time altered pursuant to the provisions of Rule 11;
		
	“Sale”	  	the making of one or more agreements (whether conditional or not) for an acquisition of the Capital of the Company giving rise to a change of Control of the Company;
		
	“Schedule 5”	  	Schedule 5 ITEPA;
		
	“Scheme”	  	means the NuCana Biomed Limited Share Option Scheme;
		
	“Secondary NIC Liability”	  	any employer’s secondary NIC charge arising on the exercise or release of an Option;
		
	“Share”	  	a fully paid ordinary share of the Company;
		
	“Subsidiaries”	  	a subsidiary as defined under section 736 Companies Act 1985;

  
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	“Tax Liabilities”	  	any income tax and NIC charge arising as a consequence of the exercise or release of the Option or in respect of the Shares acquired pursuant to the exercise of such options and including arising under a Joint Election or receipt of
money or money’s worth in connection with such Options or the acquired Shares, for which the Company or a Group Member has accounted or is required to account for to HMRC and including, unless otherwise stated, where permitted by law the
employer’s national insurance contributions (or their equivalent);
		
	“TCGA”	  	the Taxation of Chargeable Gains Act 1992;
		
	“UK Listing Authority”	  	the Financial Services Authority acting in its capacity as the competent authority for the purposes of Part VI Financial Services and Markets Act 2000;
		
	“Unapproved Option”	  	 an option to acquire Shares granted under this Scheme and subject to these Rules which:

 
 (a)    is designated an
Unapproved Option; and/or
  

(b)    does not fall within the provisions of Schedules 3, 4 or 5 ITEPA and does not satisfy the
EMI Code but in respect of which these Rules apply.

  

	1.2	Words denoting the singular shall include the plural and vice versa and words denoting the masculine gender shall include the feminine gender. 

 

	1.3	Rule headings are inserted for convenience only and are to be ignored in construing these Rules. 

  

	1.4	References in these Rules to any statute shall be deemed to include every modification, amendment and/or re-enactment by statute or
sub-ordinate legislation for the time being in force. 

  

	1.5	References in these Rules to “month’ shall be deemed to be references to a calendar month. 

  

	2.	PROVISIONS RELATING TO THE GRANT OF OPTIONS 

  

	2.1	In its absolute discretion, the Board has the power to grant Options (whether EMI Options or Unapproved Options) under the Scheme to Eligible Employees: 

 

	 	(a)	subject to the limitations and conditions contained in these Rules; 

  

	 	(b)	provided they are not prohibited by law; and 

  
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	 	(c)	for commercial reasons in order to recruit or retain an Eligible Employee in the Group. 

  

	2.2	The procedure for granting Options shall be as follows: 

  

	 	(a)	the Board shall by resolution: 

  

	 	(i)	select a number of Eligible Employees to whom Options shall be granted and the intended Date of Grant; 

  

	 	(ii)	determine the maximum number of Shares which each such Eligible Employee shall be entitled to acquire on the exercise of the Options; 

 

	 	(iii)	determine the Option Price, the periods during which Options may be exercised, and any Exercise Conditions to apply to the option to be granted; 

 

	 	(iv)	specify which Options shall be EMI Options or Unapproved Options; 

  

	 	(v)	determine if the Option Holder is to indemnify against secondary NIC Liability under Rule 2.6; 

  

	 	(b)	the Board shall send to each selected Eligible Employee the following documents to invite him or her to enter into an Option Agreement: 

 

	 	(i)	a Letter of Invitation; 

  

	 	(ii)	a copy Letter of Invitation (to sign and return); 

  

	 	(iii)	an Option Agreement; 

  

	 	(iv)	a Notice of Grant; 

  

	 	(v)	a copy of the Rules; 

  

	 	(vi)	any Explanatory Notes (if prepared); and 

  

	 	(vii)	the Articles of Association of the Company; 

  

	 	(c)	the Option Agreement must be duly executed by the Company and the Eligible Employee within 14 days of the date of the Letter of Invitation (or such other date determined by the Board) and the date when the Option
Agreement is duly executed shall be the date of the Date of Grant. 

  

	2.3	The Option Agreement shall serve as evidence of the grant of the Option and accordingly no further certificate shall be issued to the Option Holder. 

 

	2.4	The Option shall state if the Option is being granted as an EMI Option, or to what extent it is being granted as an EMI Option; otherwise it shall be granted as an Unapproved Option. 

  
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	2.5	If an Option Agreement is not duly executed as required under Rule 2.2 within the time limit specified the terms of the Letter of Invitation shall immediately lapse at the end of the period referred to therein and the
Option shall not be granted nor be deemed to have been granted to the Eligible Employee. 

  

	2.6	It shall be a condition of the grant of an Option that the Option Holder: 

  

	 	(a)	indemnifies the Company and any other Group Member to the extent permitted by law against any Tax Liabilities and where the Board so requires Secondary NIC Liability (together referred to as
“Liabilities”); and 

  

	 	(b)	enters into a Joint Election should the Board so require at any time prior to and as a condition of the exercise of the Option. 

  

	3.	LIMITS AND OTHER RESTRICTIONS OF THE SCHEME RULES 

  

	3.1	An EMI Option granted to an Eligible Employee under these Rules shall be limited and take effect so that the aggregate Market Value at the Date of Grant of Shares which may be acquired on the exercise of that EMI Option
when added to: 

  

	 	(a)	the aggregate Market Value at the Date of Grant of Shares which may be acquired on the exercise of Qualifying Options granted to him pursuant to the Scheme and Any Other EMI Scheme; and 

 

	 	(b)	the aggregate Market Value at Date of Grant of Shares which may be acquired on the exercise of any Relevant CSOP Option held by such Eligible Employee at the Date of Grant 

 

	 	shall	not exceed £120,000 or such other sum as determined under paragraph 5 Schedule 5. 

  

	3.2	To the extent that the aggregate Market Value of Shares under any EMI Option exceeds such sum as referred to in Rule 3.1, any Option granted over Shares representing the excess shall be granted under an Unapproved
Option. 

  

	3.3	Pursuant to Rule 3.1 the Market Value of Shares shall be calculated at the time the options in relation to those Shares is granted or such other time as agreed in writing by HMRC. 

 

	3.4	If an Eligible Employee has previously been granted Qualifying Options under the Scheme or Any Other EMI Scheme over Shares with an aggregate Market Value of £120,000 as referred to in Rule 3.1 above (including
EMI Options which have since been exercised or released) then any Option which shall be granted to such Eligible Employee within three years of the Date of Grant of the last such Qualifying Option shall be an Unapproved Option. 

 

	3.5	No Option shall be granted at a date more than ten years after the Adoption Date without further authorisation by the Company in general meeting. 

  
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	3.6	Notwithstanding any other provisions of these Rules the Company may not issue Qualifying Options under the Scheme or any Other EMI Scheme such that the Market Value at the date of grant of Shares subject to such
Qualifying Options exceeds £3 million or such other sum as determined under paragraph 7 Schedule 5. 

  

	4.	NON-ASSIGNABILITY OF OPTIONS 

 Except as
otherwise specifically provided in these Rules, each Option shall be exercisable only by the Option Holder to whom it is granted and may not be transferred, assigned or charged, and on any purported transfer, assignment or charge the Option shall
automatically lapse. 
  

	5.	EXERCISE CONDITIONS 

  

	5.1	Exercise Conditions (if any) shall be: 

  

	 	(a)	in respect of dates or events or profits or individual or collective performance criteria for a period which begins no earlier than the start of the accounting period in which the Date of Grant falls; and

  

	 	(b)	capable of independent objective assessment with a view to determining whether they have been satisfied; and 

  

	 	(c)	set out in detail at the Date of Grant in the Option Agreement. 

  

	5.2	Different Exercise Conditions may be specified in respect of different numbers of the Shares comprised in the same Option. 

  

	5.3	Subject to the provisions of these Rules where an Option has been granted subject to Exercise Conditions, the Board shall as soon as reasonably practicable following the satisfaction of any Exercise Conditions give
written notice to inform the Option Holder concerned that his Option has become exercisable subject always to the provisions of Rule 6. 

  

	5.4	Where events happen which cause the Board to consider that the Exercise Conditions are no longer appropriate, or the Board at its entire discretion so decides, it may: 

 

	 	(a)	vary the Exercise Conditions provided that the new Exercise Conditions are not more difficult to satisfy than the original Performance Conditions; or 

 

	 	(b)	remove the Exercise Conditions as a requirement of the exercise of the Option; 

 PROVIDED that
the Option Holder is given notice in writing of the variation or removal as soon as practicable. 
  

	6.	EXERCISE OF OPTION 

  

	6.1	An Option shall be exercised:- 

  

	 	(a)	pursuant to the terms of exercise set out in the Option Agreement; and 

  
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	 	(b)	by lodging with the Company Secretary or such other person as the Board may specify, the relevant Option Agreement, a duly completed Notice of Exercise and (subject to Rule 8.6) the payment required in respect of the
Option Price and any Tax Liabilities and secondary NIC liability. 

  

	6.2	Lapse of Options 

 An Option shall cease to be exercisable and shall lapse forthwith on
the occurrence of the following events:- 
  

	 	(a)	5pm on the day before the tenth anniversary of the grant of the Option; 

  

	 	(b)	the Option Holder does or suffers any act or thing (including bankruptcy) whereby he would or might be deprived of the legal or beneficial ownership of the Option; 

 

	 	(c)	the lapsing events referred to in Rules 4, 7, 8 and 9. 

  

	6.3	Result of Exercise of Options 

  

	 	(a)	Subject to: 

  

	 	(i)	the obtaining of any necessary consent from H.M. Treasury, the Bank of England, the UK Listing Authority, the London Stock Exchange Plc or other relevant authority; 

 

	 	(ii)	the terms of any such consent; 

  

	 	(iii)	receipt by the Company of the appropriate payment for Shares to be acquired on exercise in full 

the Company shall (subject to Rule 8.7) within 30 days of receipt by the Company Secretary of a valid Notice of Exercise issue to or arrange
the transfer to the Option Holder the number of Shares in respect of which the Option has been exercised (but if during a Close Period such issue or transfer shall be effected as soon as reasonably practicable after the end of the Close Period).

  

	 	(b)	The Board shall at all times keep available sufficient unissued Shares or shall procure that there are available sufficient Shares to satisfy the exercise of all Options granted under the Scheme. For this purpose the
Board may enter into an agreement with any individual, company or the trustees of any employee benefit trust for the provision by such persons of Shares to satisfy Options. In such case, and if appropriate, the Option Price payable by the Option
Holder shall be received by a member of the Board as trustee for such persons (to whom it shall account) and the Board shall procure the transfer of Shares by such persons upon exercise of the Option. 

 

	 	(c)	All Shares issued on exercise of Options shall on issue rank equally in all respects with the Company’s existing Shares of the same class, save that the Shares issued under the Scheme will not rank for any
dividends or other distributions declared or recommended the record date for which falls on or prior to the date when the Option is exercised. 

  
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	6.4	Tax Liability 

  

	 	(a)	It being a condition of the grant of an Option that each Option Holder indemnifies the Company and any other Group Member against Tax Liabilities and/or secondary NIC Liabilities (“Liabilities”) pursuant to
Rule 2.6(a), to the extent that the Liabilities cannot be (or are not) deducted from payments made by the Company or Group Member to the Option Holder, the Company shall be authorised by the Option Holder:- 

 

	 	(i)	to retain and sell on the Option Holder’s behalf sufficient Shares issued or acquired on exercise of the Option to raise the necessary funds to meet and to apply such funds in discharging the Liabilities or
reimbursing the Company or the relevant Group Member; and/or 

  

	 	(ii)	to make such other arrangements with the Option Holder in question as the Board deems appropriate for the reimbursement to the Company or relevant Group Member of the Liabilities. 

 

	7.	DEATH OF OPTION HOLDER  

 Subject to Rule 6.2 and subject to Rule 5: 

 

	7.1	If an Option Holder dies before exercising an Option or part thereof, the Option may (and must, if at all) be exercised by his personal representatives to the extent that any Exercise Conditions have been met within the
period ending on the earlier of: 

  

	 	(a)	the expiry of 12 months after the date of death; and 

  

	 	(b)	the time referred to in Rule 6.2(a), 

 and failing such exercise the Option shall lapse. 

 

	8.	CHANGE OF CONTROL, AND SALE OF THE COMPANY 

  

	8.1	Change of Control - If: 

  

	 	(a)	any person or group of persons acting in concert obtains Control of the Company as a result of making: 

  

	 	(i)	an offer to acquire more than 50% of the Capital of the Company which is made on a condition such that if it is satisfied the person or group of persons will have Control of the Company; or 

 

	 	(ii)	a general offer to acquire all the Capital (or all the shares which are of the same class of those to which the Option relates); or 

  
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	 	(b)	any person becomes entitled or bound to acquire shares in the capital of the Company under Sections 428 to 430F of the Companies Act 1985; or 

 

	 	(c)	under Section 425 of the Companies Act 1985 the court sanctions a compromise or arrangement proposed for the purposes of or in connection with a scheme for the reconstruction of the Company or its amalgamation with
any other company or companies; 

 and if the Option Agreement allows for exercise of the Option on a Change of Control, an
Option Holder (or his personal representative) may at any time during the three days prior to or within the Appropriate Period, exercise any Option or part thereof which has not lapsed. Any Option which is not so exercised shall lapse at the expiry
of the Appropriate Period. 
  

	8.2	Replacement Options: 

  

	 	(a)	If a company (in this Rule called the “Acquiring Company”) has acquired Control of the Company as a result of any of the events described in Rule 8.1(a) or 8.1(c), or becomes entitled or bound as
mentioned in Rule 8.1(b) or obtains all the shares of the Company whose shares are subject to any outstanding Qualifying Options as a result of a qualifying exchange of shares (as defined in paragraph 40(1) Schedule 5) (such acquiring of Control or
becoming entitled or bound or obtains, being referred to below as a “Specific Event”), any Option Holder may by agreement with the Acquiring Company at any time within the Appropriate Period as defined in Rule 8.3 below release his
rights in respect of any EMI Option held by him (in this Rule referred to as the “Old Option”) in consideration of the grant to him of rights (in this Rule referred to as the “Replacement Option”) which are
equivalent and relate to shares in the Acquiring Company, and which comply with Rule 8.2(b). 

  

	 	(b)	A Replacement Option is one in relation to which the requirements of paragraph 43 of Schedule 5 are satisfied at the time of release of the Old Option including grant by reason of the Option Holder’s employment
with the Acquiring Company. 

  

	8.3	“Appropriate Period” means: 

  

	 	(a)	in a case falling within Rule 8.1(a) and where Rule 8.1(b) does not apply, the period of six months beginning with the time when the person making the offer has obtained Control of the Company and any condition subject
to which the offer is made is satisfied; 

  

	 	(b)	in a case falling within Rule 8.1(b) the period during which the person remains bound or entitled as mentioned in that paragraph; and 

 

	 	(c)	in a case falling within Rule 8.1(c) the period of six months beginning with the time when the court sanctions the compromise or arrangement. 

  
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	8.4	If a Replacement Option shall be granted to an Option Holder by reference to any Specific Event, Rules 8.1(a), 8.1(b) and 8.1(c) above shall cease to apply by reference to that Specific Event (but without prejudice to
their application by reference to any other Specific Event). Any EMI Option which is not exercised or released pursuant to this Rule within the Appropriate Period following a Specific Event (but not any Replacement Option granted by reference to
that Specific Event) shall lapse. 

  

	8.5	Sale: If the Option Agreement allows for exercise of the Option on a Sale, in the event that the Board becomes aware that there may be a Sale of the Company they shall give notice (a “Sale
Notice”) in writing to the Option Holder specifying that a Sale may be forthcoming and that the Option will lapse immediately following the sale if not exercised prior to completion of the Sale unless a Replacement Option is offered to the
Option Holder in accordance with Clause 8.2 (or unless some other form of replacement option is offered by the prospective purchaser). 

  

	8.6	At any time after receipt of a Sale Notice under Clause 8.5 and prior to completion of the Sale, the Option Holder may exercise the Option in accordance with Clause 6 but only on the basis that the Option Holder agrees
to sell to the purchaser on completion of the Sale all the Shares acquired as a result of the exercise of the Option. Any such Exercise Notice from the Option Holder shall be accompanied by a cheque for the aggregate Option Price but shall specify
the number of Shares over which the Option Holder wishes to exercise his Option, and any such notice may not be withdrawn without the consent of the Board. 

  

	8.7	Completion of the subscription for, or transfer of, the Shares shall take place prior to completion of the Sale and the Company shall issue and allot the relevant Shares in favour of the Option Holder and shall register
such issue and allotment or transfer prior to completion of the Sale. 

  

	8.8	In the event that the Sale proceeds are received directly by the Option Holder, the Option Holder undertakes to reimburse the Company (or any other Group Company) for a sum equal to the aggregate Option Price, along
with any Tax liabilities and/or secondary NIC Liability that may be due in relation to the exercise of the Option, whether by deduction under clause 6.4 or otherwise. 

 

	8.9	Clauses 8.5 to 8.8 above dealing with a Sale shall take priority over Clause 8.1 dealing with other forms of Change of Control and for the avoidance of doubt in the event of a Sale, Clause 8.1 will not apply but clauses
8.2 to 8.4 may apply. 

  

	9.	WINDING-UP OF THE COMPANY 

  

	9.1	If at any time while any Option remains unexercised notice is duly given of a general meeting of the Company at which a resolution will be proposed for the voluntary liquidation of the Company, every Option which has
not lapsed prior to such resolution shall be exercisable in whole or in part until the commencement of such winding-up within the meaning of Section 86 of the Insolvency Act 1986. 

 

	9.2	Pursuant to the above Rule 9.1 the Company shall give to each Option Holder holding any unexercised Option notice of any meeting called for the purpose of considering a resolution for the voluntary liquidation of the
Company and shall at the same time give him notice of his rights under this Rule 9 and subject to the foregoing, all Options shall lapse on the commencement of any liquidation of the Company. 

  
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	10.	VARIATION OF CAPITAL 

  

	10.1	Subject to Rules 10.3 and 10.4 below, in the event of any increase or variation of the Capital (whenever effected) by way of capitalisation or rights issue, or sub-division,
consolidation or reduction, the Board may make such adjustments as they consider appropriate under Rule 10.2 below. 

  

	10.2	An adjustment made under this Rule 10 shall be to one or more of the following: 

  

	 	(a)	the number of Shares in respect of which any Option granted under the Scheme may be exercised; 

  

	 	(b)	the price at which shares may be acquired by the exercise of any such Option; 

  

	 	(c)	where any such Option has been exercised but no Shares have been transferred pursuant to such exercise, the number of Shares which may be so transferred and the price at which they may be acquired. 

 

	10.3	Except in the case of a capitalisation issue, no adjustment under Rule 10.2 above shall be made without the prior confirmation in writing by the Auditors or other share valuers to the Board that it is in their opinion
fair and reasonable. 

  

	10.4	No adjustment under Rule 10.2 above shall be made 

  

	 	(a)	which would affect EMI Options which are Qualifying Options without the prior approval of HM Revenue and Customs if so required; 

  

	 	(b)	as a result of which the aggregate amount payable on the exercise of an Option in full would be increased or reduced. 

  

	10.5	An adjustment under Rule 10.2 above may have the effect of reducing the price at which Shares may be acquired by the exercise of the Option to less than their nominal value, but only if and to the extent that the Board
shall be authorised to capitalise from the reserves of the Company a sum equal to the amount by which the nominal value of the Shares in respect of which the Option is exercised and which are to be allotted pursuant to such exercise exceeds the
price at which the same may be subscribed for, and to apply such sum in paying up such amount on such Shares, and so that on exercise of any Option in respect of which such a reduction shall have been made, the Board shall capitalise such sum (if
any) and apply the same in paying up such amount as aforesaid. 

  

	10.6	As soon as reasonably practicable after making any adjustment under Rule 10.2 above, the Board shall give notice in writing thereof to each Option Holder. 

  
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	11.	ALTERATIONS TO THE RULES 

  

	11.1	The Board may by resolution at any time make any alteration to the Rules which it thinks fit subject to the provisions of this Rule 11. 

 

	11.2	No such alteration which would affect an EMI Option which is a Qualifying Option shall take effect if the result would be: 

  

	 	(a)	to increase the aggregate Market Value of the Shares that are the subject of such Qualifying Option; or 

  

	 	(b)	that the requirements of Schedule 5 would cease to be met in relation to such EMI Option. 

  

	11.3	No alteration shall be made which would materially increase the liability of any Option Holder or which would materially decrease the value of his subsisting rights attached to any Option without in each case that
Option Holder’s prior written consent. 

  

	11.4	No alteration shall take effect without the prior approval of the Company in general meeting (except for minor amendments to benefit administration of the Scheme, to comply with or to take account of any applicable
legislation or statutory regulations or any change therein or any requirements of HM Revenue and Customs for the approval of the Scheme under any such legislation or regulations or to obtain or maintain favourable taxation treatment for the Company
or the Option Holders or potential Option Holders). 

  

	11.5	As soon as reasonably practicable after making any alteration under Rule 11.1 above the Board shall give notice in writing thereof to each Option Holder. 

 

	12.	MISCELLANEOUS 

  

	12.1	Any Option granted pursuant to the Rules shall not form part of the contract of employment of any person who participates in the Scheme. The rights and obligations of any individual under the terms of his office or
employment with any Group Member shall not be affected by his participation in the Scheme or any right which he may have to participate therein, and an individual who participates therein shall waive any and all rights to compensation or damages in
consequence of the termination of his office or employment for any reason whatsoever (including unfair or wrongful dismissal) insofar as those rights arise or may arise from his ceasing to have rights under or be entitled to exercise any Option
under the Scheme as a result of such termination. No such participation, rights or benefits shall be taken into account for the purposes of calculating the amount payable to any pension fund. Options granted pursuant to the Scheme shall not
constitute any representation or warranty that any benefit will accrue to any individual who is granted an Option. 

  

	12.2	 The Scheme shall in all respects be administered by the Board who may from time to time make and vary such rules
and regulations for its conduct not inconsistent with these Rules and may from time to time establish such procedures for administration and implementation of the Scheme and 

  
 15 

	 	
Rules as it thinks fit, and in the event of any dispute or disagreement as to the interpretation of the Rules, or of any rule, regulation or procedure, or as to any question or right arising from
or related to the Scheme, the decision of the Board shall be final and binding upon all persons (subject to the written concurrence of the Auditors having been obtained when so required by the Rules). 

 

	12.3	Any Group Member may provide money to the trustees of any trust or any other person to enable them or him to acquire shares to be held for the purposes of the Scheme, or enter into any guarantee or indemnity for these
purposes, to the extent permitted by section 153 of the Companies Act 1985. 

  

	12.4	In any matter in which they are required to act under the Rules, the Auditors shall be deemed to be acting as experts and not as arbitrators and the Arbitration Acts 1950 to 1996 shall not apply to these Rules.

  

	12.5	Any notice or other communication under or in connection with the Rules may be given by personal delivery or by sending the same by post, in the case of a company to its registered office and in the case of an
individual to his last known address, or, where he is a director or employee of a Company participating in the Scheme, either to his last known address or to the address of the place of business at which he performs the whole or substantially the
whole of the duties of his office or employment, and where a notice or other communication is given by first-class post, it shall be deemed to have been received 48 hours after it was put into the post properly addressed and stamped.

  

	12.6	The costs of introducing and administering the Scheme shall be borne by the Company or any Group Member. 

  

	12.7	The Board shall maintain all necessary books of account and records relating to the Scheme. 

  

	12.8	Subject to the Articles of Association of the Company, an Option Holder who is a director of the Company may, notwithstanding his interest, vote on any resolution concerning the Scheme (other than in respect of his own
participation therein) and may retain any benefits under the Scheme. 

  

	13.	GOVERNING LAW 

 The Rules and the Scheme shall in all respects be governed by the
laws of England. 
 Form of Option Agreement 

This Agreement which is in the form of a deed is made the day of             200● 

BETWEEN 
  

	(1)	NuCana Biomed Limited (03308778 ) whose registered office is at Butler & Co Accountants, 5 Southwell Park Road, Camberley, Surrey, GU15 3PU (“Company”); and 

 

	(2)	[employee name] of [employee address] who will become “the Option Holder” 

  
 16 

 RECITALS 
  

	A.	This EMI/Unapproved Option is granted subject to the rules of the                NuCana Biomed Limited Share Option Scheme, and is granted
pursuant to Schedule 5 ITEPA 2003 (“Scheme”). 

  

	B.	A copy of the rules which is appended to this Agreement provides for the grant of options for commercial reasons in order to recruit and retain key employees (“Rules”). 

NOW THIS AGREEMENT WITNESSES 
  

	1.	In this Agreement the definitions in the Rules shall apply. 

  

	2.	The Company hereby grants to the Option Holder the EMI Option to acquire a maximum of [                ] Shares, at an Option Price of *
per Share. 

  

	3	Exercise  

  

	 	3.1	The options shall be exercisable as follows: 

  

	 	•	 	X options may be exercised at any time after 12 months from the date of grant 

  

	 	•	 	a further X options may be exercised at any time after 24 months from the date of grant 

  

	 	•	 	the final X options may be exercised at any time after 36 months from the date of grant 

  

	 	3.2	All unexercised options will also be able to be exercised on the occasion of Admission, a change of control, or sale of the company. 

 

	4.	The EMI/Unapproved Option may not be exercised: 

  

	 	4.1	after the time in Rule 6.2(a); 

  

	 	4.2	from the date the Option Holder ceases to be an employee of the Company or of any Qualifying Subsidiary [except to the extent provided in Rule 7; 

 

	 	4.3	following a Change of Control or a Sale of the Company except to the extent provided in Rule 8; 

  

	 	4.4	following the commencement of the winding up of the Company as set out in Rule 9. 

  

	5.	The EMI/Unapproved Option will lapse on the occurrence of any of the events as set out in Rule 6.2. 

  

	6.	To exercise the EMI/Unapproved Option the Option Holder must lodge with the Company Secretary of the Company (or such other person as the Company may from time to time notify to the employee in writing):

  

	 	6.1	this Option Agreement; 

  
 17 

	 	6.2	a duly completed Notice of Exercise in the form appended to this Option Agreement; 

  

	 	6.3	where required by the Company, a duly completed Joint Election; and 

  

	 	6.4	a cheque made payable to the Company in respect of the Option Price. 

  

	7.	The employee hereby: 

  

	7.1	covenants with the Company to allow the Company to recover from the Option Holder Tax Liabilities arising in connection with or as a result of the exercise of the EMI/unapproved Option and to indemnify and keep
indemnified on a continuing basis the Company and any Group Member in respect of such Tax Liabilities and for the purposes of such indemnity: 

  

	7.2	hereby authorises the Company to deduct sufficient funds which, in the reasonable opinion of the Board, would be equal to any Tax Liabilities from any payment made to or in respect of the Option Holder by it or any
Group Member during the same calendar month or other relevant period in which such Tax Liabilities arise. If there is no such payment made or the Tax Liabilities exceed the amount of such payment the Option Holder hereby agrees to pay the full
amount of the Tax Liabilities or any such excess (as the case may be) in cleared funds within seven days of a valid demand by the Company or any Group Member; and 

 

	7.3	appoints a member of the Board as his [trustee] for the purposes of providing the Company or any Group Member (as appropriate) with sufficient funds to recover any Tax Liabilities by receiving on trust or retaining on
trust (as the case may be) (out of the total number of Shares to which the Option Holder is entitled following the relevant exercise of the EMI/unapproved Option) the legal title to and selling such number of Shares as, in the reasonable opinion of
the Board, is required to realise a cash amount equivalent to the Tax Liabilities and the Option Holder hereby covenants to pay to the Company, should such sale realise a cash amount less than the Tax Liabilities, an amount equal to the difference
within seven working days of demand by the Company. 

  

	8.	The EMI/unapproved Option is exercisable only by the Option Holder (or his personal representatives) and may not be transferred, assigned or charged and the EMI/unapproved Option will lapse on the occasion of any
assignment, charge, disposal or other dealing with the rights conveyed by it. 

  

	9.	The Company has agreed or will agree the Market Value of a Share for the purposes of this Scheme as at the Date of Grant with HM Revenue and Customs. 

 

	10.	A person who is not a party to this deed shall have no right under the Contracts (Rights of Third Parties) Act 1999 to enforce any term of this deed. This clause does not affect any right or remedy of any person which
exists or is available otherwise than pursuant to that Act. 

  

	11.	The Shares which will be acquired when the Option is exercised are subject to the terms and restrictions set out in the Company’s articles of association, and a copy of the current articles of association is
attached. 

  
 18 

 APPENDIX 

Form of Notice of Exercise 

Please read the notes at the foot of his form carefully before completing it 

 

	To:	The Secretary 

 NuCana Biomed Limited 

I, the undersigned1, having become entitled so to do, hereby exercise the EMI Option referred to in the
attached Agreement in respect of Shares comprised in the EMI/Unapproved Option upon the terms of the NuCana Biomed Limited Share Option Scheme (“Scheme”) and agree to accept the Shares to be allotted and issued pursuant to this
Notice of Exercise subject to and in accordance with the memorandum and articles of association of the Company and hereby request you to place my name on the register of members in respect thereof. 

I enclose a remittance for £2 being the aggregate Option Price payable for the Shares in respect of
which the EMI/Unapproved Option is now exercised, the Option Price (per Share) being [                ]. 

I understand that income tax and NIC (referred to as a Tax Liabilities in the Rules of the Scheme) may need to be accounted for by the Company to HM Revenue
and Customs on this exercise and in respect of which I have indemnified the Company. I further understand that the Company has an obligation to deduct, insofar as possible, the amount of any Tax Liabilities from payments that it makes to me and I
authorise the Company to make such deductions from my salary. 
 (please tick as appropriate3)

  

			
	☐	  	I wish to make a cash payment to the Company in respect of the outstanding Tax Liabilities (after deduction by the Company) arising from this exercise and enclose a second cheque made payable to the Company for
£●.
		
	☐	  	I authorise the Company to retain and to sell on my behalf sufficient Shares so as to realise an amount sufficient to discharge the Tax Liabilities arising from this exercise.

 If applicable, I hereby request you to despatch a balance certificate for the [EMI/Unapproved] Option to subscribe for any
Shares included in the [EMI/Unapproved] Option referred to overleaf and not exercised on this occasion, by post at my risk to the address mentioned below. 
  

							
	Signature:    	  	  
	  		  	Date:                                     
    
				
	Surname:    	  	  
	  		  	
				
	Forename(s):	  	  
	  		  	
				
	Address:    	  	  
	  		  	
		  	  
	  		  	
		  	  
	  		  	
		  	  
	  		  	

 [If the shares are restricted under ITEPA the Option Holder should be required to enter into a Joint Election with the
Company to which this Exercise Notice should refer.] 
  

	1 	Although the Option referred to overleaf is personal to the holder named overleaf it may be exercised by his personal representative(s) if he dies while the Option is still capable of exercise provided the
personal representative(s) does/do so before the expiration of 12 months from the date of the Option Holder’s death or 10 years from the date of its grant (if sooner). If there are more than one, each of the personal representatives must sign
this form. A copy of the Grant of Probate must be provided with the completed Notice of Exercise. 

	2 	The remittance should be for an amount equal to the Option Price per Share shown overleaf, multiplied by the number of Shares applied for. 

	3 	Please tick the appropriate box. If you fail to tick a box or if you tick the first box but your cash payment or next month’s salary are insufficient to cover the full liability, the Company will retain and sell
sufficient shares to cover the liability or shortfall or will withhold the transferring of the shares to you until the full tax liabilities have been met by you. 

 In Witness whereof the parties have signed this Agreement on the date specified above: 

 

			
	EXECUTED as a DEED	  	)
	but not delivered until the date hereof	  	)
	for and on behalf of THE COMPANY	  	)
		
		  	Director
		
		  	Director/Secretary
		
	SIGNED as a DEED	  	)
	but not delivered until the date hereof	  	)
	by ●	  	)
	in the presence of:	  	)

  

							
	Name of Witness	  	  
	  		  	
	AddressEX-10.2

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 Exhibit 10.2 

RULES OF THE 
 NuCana
BioMed Limited 
 SHARE OPTION SCHEME (INCLUDING ENTERPRISE MANAGEMENT INCENTIVES) 

Approved and Adopted by the Board of NuCana BioMed Ltd 

On 3rd July 2012 

Table of Contents

 CONTENTS 

 

					
	 1.      INTERPRETATION
	  	 	1	 
	 2.      
PROVISIONS RELATING TO THE GRANT OF OPTIONS
	  	 	7	 
	 3.      
LIMITS AND OTHER RESTRICTIONS OF THE SCHEME RULES
	  	 	8	 
	 4.     
 NON-ASSIGNABILITY OF OPTIONS
	  	 	9	 
	 5.      EXERCISE
CONDITIONS
	  	 	9	 
	 6.      EXERCISE OF OPTION
	  	 	10	 
	 7.      
BAD LEAVER OR DEATH OF OPTION HOLDER
	  	 	12	 
	 8.      
CHANGE OF CONTROL, AND SALE OF THE COMPANY
	  	 	13	 
	 9.     
 WINDING-UP OF THE COMPANY
	  	 	15	 
	 10.    VARIATION OF CAPITAL
	  	 	15	 
	 11.    ALTERATIONS TO THE RULES
	  	 	16	 
	 12.    MISCELLANEOUS
	  	 	16	 
	 13.    GOVERNING LAW
	  	 	18	 

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 NuCana Biomed Limited 

SHARE OPTION SCHEME 

RULES 
 (INCLUDING
ENTERPRISE MANAGEMENT INCENTIVES) 
  

	1.	INTERPRETATION 

  

	1.1	In these Rules (unless the context otherwise requires) the following words and expressions shall have the following meanings: 

  

	 “Admission” 
	the admission of part of or the entire issued share capital of the Company (or any holding company of the Company) to listing on the Official List of the UK Listing Authority and to trading on the market for listed securities of London Stock
Exchange plc, or to trading on AIM or to trading on any recognised investment exchange (as that term is defined in S841 ICTA) 

  

	 “Adoption Date” 
	the date on which the Scheme is adopted by the Board/Company; 

  

	 “AIM” 
	the market of that name operated by the London Stock Exchange Plc; 

  

	 “Any Other EMI Scheme” 
	any scheme (other than the Scheme) adopted by the Company or any Group Member or by the Board which provides for the grant of options to acquire Shares which are Qualifying Options; 

 

	 “Any Other Scheme” 
	any scheme (other than the Scheme) approved by the Company in general meeting or adopted by the Board which provides for the acquisition of Shares by or on behalf of employees or directors of the Group; 

 

	 “Appropriate Period” 
	as defined in Rule 8.3; 

  

	 “Associated Company” 
	has the meaning given to that expression by Section 416 ICTA; 

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	 “Auditors” 
	the auditors for the time being of the Company (acting as experts and not as arbitrators); 

  

	 “Board” 
	the board of directors for the time being of the Company or a committee thereof duly authorised for the purposes of the Scheme; 

  

	 “Capital” 
	issued ordinary share capital of the Company; 

  

	 “Close Period” 
	any period where there are restrictions on dealing in the shares as stipulated by a relevant authority including under the rules of AIM; 

  

	 “Company” 
	NuCana BioMed Limited registered in the UK with registration number 03308778 and whose registered address is Butler & Co Accountants, 5 Southwell Park Road, Camberley, Surrey, GU15 3PU; 

 

	 “Control” 
	has the meaning given to it by Section 840 ICTA and “Controlled” shall have a similar meaning; 

  

	 “Date of Grant” 
	the date on which an Option was or is to be granted under Rule 2; 

  

	 “Eligible Employee” 
	An employee or director of the Company or of a Qualifying Subsidiary and additionally, in the case of an Option which is to be granted as an EMI Option, a person who also satisfies the requirements of paragraphs 25 and 26 of Schedule 5, and
whose average amount per week of reckonable time in relevant employment (as defined in Section 535(3) ITEPA and paragraph 26 Schedule 5) during a tax year is not less than 25 hours a week or such other relevant statutory threshold;

  

	 “EMI Code” 
	the provisions set out in Sections 527 to 541 ITEPA (inclusive), Schedule 5 and Part 4 Schedule 7D TCGA; 

  

	 “EMI Option” 
	a right (for the time being subsisting) to acquire Shares under the Scheme in accordance with these Rules and which is a Qualifying Option; 

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	 “Exercise Conditions” 
	conditions, if any, determined by the Board at the Date of Grant and as set out in the Appendix of the Option Agreement required to be satisfied before the Option can be exercised, such conditions being subject to the provisions set out in Rule
5; 

  

	 “FSMA” 
	the Financial Services and Markets Act 2000; 

  

	 “Good Leaver” 
	an Option Holder who ceases to be an Eligible Employee of the Company or of a Qualifying Subsidiary by reason: 

(a)    of cessation of employment or office with any Group Member due to ill health, injury or
disability, redundancy or retirement on reaching the age at which he is bound to retire in accordance with the terms of his contract of employment; or 

(b)    only that his office or employment is in a company of which the Company ceases to have Control;
or 
 (c)    his office or employment relates to a business or part of a business which is transferred
to a person who is neither an Associated Company of the Company nor a company of which the Company has Control ; or 

(d)    cessation of employment or office for any other reason, apart from summary dismissal with just
cause. 
  

	 “Group” 
	the Company and its Subsidiaries and “Group Member” shall be construed accordingly; 

  

	 “HMRC” 
	HM Revenue and Customs; 

  

	 “ICTA” 
	the Income and Corporation Taxes Act 1988; 

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	 “ITEPA” 
	the Income Tax (Earnings and Pensions) Act 2003; 

  

	 “Joint Election” 
	means a joint election pursuant to Sections 425, 430 or 431 ITEPA; 

  

	 “Letter of Invitation” 
	a letter substantially in the form set out in schedule 1 to these Rules provided by the Company to an employee inviting him to accept the grant of an Option; 

 

	 “Market Value” 
	has the same meaning as it has for the purposes of Part VIII TCGA and which shall be deemed to be: 

(a)    the middle market quotation of a Share as decided from the Official List for the dealing day
immediately preceding the Date of Grant; or 
 (b)    (if the Shares are not for the time being so
quoted) the price determined by the Board, as being the market value of a Share on the day prior to the day on which the Option in question is granted 
  

	 	and, for an EMI Option agreed by Shares Valuation at HMRC; 

  

	 “Material Interest” 
	means an interest in the Company as set out in paragraph 29 of Schedule 5; 

  

	 “NIC” 
	national insurance contributions; 

  

	 “Notice of Exercise” 
	a notice of exercise substantially in the form set out in the Appendix to the Option Agreement; 

  

	 “Notice of Grant” 
	in the case of Options which are to be EMI Options, a notification to HMRC to be jointly signed by 

(a)    the employer company of the Option Holder and 

(b)    the Option Holder in such form required by HMRC from time to time; 

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	 “Official List” 
	the official listing as referred to in Part VI FSMA; 

  

	 “Option” 
	an option to acquire Shares granted under these Rules, whether an EMI Option or an Unapproved Option; 

  

	 “Option Agreement” 
	a written agreement between the Company and the Option Holder in the form of a deed substantially in the form set out in schedule 2 to these Rules and if it is an EMI Option containing the information required by Schedule 5; 

 

	 “Option Holder” 
	a person who holds an Option or (where the context admits) his personal representatives; 

  

	 “Option Price” 
	the price at which each Share may be acquired on the exercise of an Option determined by the Board at the Date of Grant [being not substantially less than the Market Value and, subject to Rule 10, not less than the nominal value of the Share
where the Shares are to be acquired by direct issue from the Company; 

  

	 “Qualifying Option” 
	an option which at the time of grant meets the requirements of Schedule 5 and in respect of which a Notice of Grant is executed; 

  

	 “Qualifying Subsidiary” 
	has the meaning given in paragraph 11 of Schedule 5; 

  

	 “Redundancy” 
	termination of employment by reason of redundancy in accordance with Section 139 Employment Rights Act 1996; 

  

	 “Relevant CSOP Option” 
	an option to acquire shares under a scheme approved pursuant to the provisions of Schedule 4 ITEPA; 

  

	 “Rules” 
	these rules of the Scheme as from time to time altered pursuant to the provisions of Rule 11; 

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	 “Sale” 
	the making of one or more agreements (whether conditional or not) for an acquisition of the Capital of the Company giving rise to a change of Control of the Company; 

 

	 “Schedule 5” 
	Schedule 5 ITEPA; 

  

	 “Scheme” 
	means the NuCana Biomed Limited Share Option Scheme; 

  

	 “Secondary NIC Liability” 
	any employer’s secondary NIC charge arising on the exercise or release of an Option; 

  

	 “Share” 
	a fully paid ordinary share of the Company; 

  

	 “Subsidiaries” 
	a subsidiary as defined under section 736 Companies Act 1985; 

  

	 “Tax Liabilities” 
	any income tax and NIC charge arising as a consequence of the exercise or release of the Option or in respect of the Shares acquired pursuant to the exercise of such options and including arising under a Joint Election or receipt of money or
money’s worth in connection with such Options or the acquired Shares, for which the Company or a Group Member has accounted or is required to account for to HMRC and including, unless otherwise stated, where permitted by law the employer’s
national insurance contributions (or their equivalent); 

  

	 “TCGA” 
	the Taxation of Chargeable Gains Act 1992; 

  

	 “UK Listing Authority” 
	the Financial Services Authority acting in its capacity as the competent authority for the purposes of Part VI Financial Services and Markets Act 2000; 

  

	 “Unapproved Option” 
	an option to acquire Shares granted under this Scheme and subject to these Rules which: 

(a)    is designated an Unapproved Option; and/or 

(b)    does not fall within the provisions of Schedules 3, 4 or 5 ITEPA and does not satisfy the EMI
Code but in respect of which these Rules apply. 

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	1.2	Words denoting the singular shall include the plural and vice versa and words denoting the masculine gender shall include the feminine gender. 

 

	1.3	Rule headings are inserted for convenience only and are to be ignored in construing these Rules. 

  

	1.4	References in these Rules to any statute shall be deemed to include every modification, amendment and/or re-enactment by statute or
sub-ordinate legislation for the time being in force. 

  

	1.5	References in these Rules to “month” shall be deemed to be references to a calendar month. 

  

	2.	PROVISIONS RELATING TO THE GRANT OF OPTIONS 

  

	2.1	In its absolute discretion, the Board has the power to grant Options (whether EMI Options or Unapproved Options) under the Scheme to Eligible Employees: 

 

	 	(a)	subject to the limitations and conditions contained in these Rules; 

  

	 	(b)	provided they are not prohibited by law; and 

  

	 	(c)	for commercial reasons in order to recruit or retain an Eligible Employee in the Group. 

  

	2.2	The procedure for granting Options shall be as follows: 

  

	 	(a)	the Board shall by resolution: 

  

	 	(i)	select a number of Eligible Employees to whom Options shall be granted and the intended Date of Grant; 

  

	 	(ii)	determine the maximum number of Shares which each such Eligible Employee shall be entitled to acquire on the exercise of the Options; 

 

	 	(iii)	determine the Option Price, the periods during which Options may be exercised, and any Exercise Conditions to apply to the option to be granted; 

 

	 	(iv)	specify which Options shall be EMI Options or Unapproved Options; 

  

	 	(v)	determine if the Option Holder is to indemnify against secondary NIC Liability under Rule 2.6; 

  

	 	(b)	the Board shall send to each selected Eligible Employee the following documents to invite him or her to enter into an Option Agreement: 

 

	 	(i)	a Letter of Invitation; 

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	 	(ii)	a copy Letter of Invitation (to sign and return); 

  

	 	(iii)	an Option Agreement; 

  

	 	(iv)	a Notice of Grant; 

  

	 	(v)	a copy of the Rules; 

  

	 	(vi)	any Explanatory Notes (if prepared); and 

  

	 	(vii)	the Articles of Association of the Company; 

  

	 	(c)	the Option Agreement must be duly executed by the Company and the Eligible Employee within 14 days of the date of the Letter of Invitation (or such other date determined by the Board) and the date when the Option
Agreement is duly executed shall be the date of the Date of Grant. 

  

	2.3	The Option Agreement shall serve as evidence of the grant of the Option and accordingly no further certificate shall be issued to the Option Holder. 

 

	2.4	The Option shall state if the Option is being granted as an EMI Option, or to what extent it is being granted as an EMI Option; otherwise it shall be granted as an Unapproved Option. 

 

	2.5	If an Option Agreement is not duly executed as required under Rule 2.2 within the time limit specified the terms of the Letter of Invitation shall immediately lapse at the end of the period referred to therein and the
Option shall not be granted nor be deemed to have been granted to the Eligible Employee. 

  

	2.6	It shall be a condition of the grant of an Option that the Option Holder: 

  

	 	(a)	indemnifies the Company and any other Group Member to the extent permitted by law against any Tax Liabilities and where the Board so requires Secondary NIC Liability (together referred to as
“Liabilities”); and 

  

	 	(b)	enters into a Joint Election should the Board so require at any time prior to and as a condition of the exercise of the Option. 

  

	3.	LIMITS AND OTHER RESTRICTIONS OF THE SCHEME RULES 

  

	3.1	An EMI Option granted to an Eligible Employee under these Rules shall be limited and take effect so that the aggregate Market Value at the Date of Grant of Shares which may be acquired on the exercise of that EMI Option
when added to: 

  

	 	(a)	the aggregate Market Value at the Date of Grant of Shares which may be acquired on the exercise of Qualifying Options granted to him pursuant to the Scheme and Any Other EMI Scheme; and 

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	 	(b)	the aggregate Market Value at Date of Grant of Shares which may be acquired on the exercise of any Relevant CSOP Option held by such Eligible Employee at the Date of Grant 

shall not exceed £120,000 or such other sum as determined under paragraph 5 Schedule 5. 

 

	3.2	To the extent that the aggregate Market Value of Shares under any EMI Option exceeds such sum as referred to in Rule 3.1, any Option granted over Shares representing the excess shall be granted under an Unapproved
Option. 

  

	3.3	Pursuant to Rule 3.1 the Market Value of Shares shall be calculated at the time the options in relation to those Shares is granted or such other time as agreed in writing by HMRC. 

 

	3.4	If an Eligible Employee has previously been granted Qualifying Options under the Scheme or Any Other EMI Scheme over Shares with an aggregate Market Value of £120,000 as referred to in Rule 3.1 above (including
EMI Options which have since been exercised or released) then any Option which shall be granted to such Eligible Employee within three years of the Date of Grant of the last such Qualifying Option shall be an Unapproved Option. 

 

	3.5	No Option shall be granted at a date more than ten years after the Adoption Date without further authorisation by the Company in general meeting. 

 

	3.6	Notwithstanding any other provisions of these Rules the Company may not issue Qualifying Options under the Scheme or any Other EMI Scheme such that the Market Value at the date of grant of Shares subject to such
Qualifying Options exceeds £3 million or such other sum as determined under paragraph 7 Schedule 5. 

  

	4.	NON-ASSIGNABILITY OF OPTIONS 

 Except as
otherwise specifically provided in these Rules, each Option shall be exercisable only by the Option Holder to whom it is granted and may not be transferred, assigned or charged, and on any purported transfer, assignment or charge the Option shall
automatically lapse. 
  

	5.	EXERCISE CONDITIONS 

  

	5.1	Exercise Conditions (if any) shall be: 

  

	 	(a)	in respect of dates or events or profits or individual or collective performance criteria for a period which begins no earlier than the start of the accounting period in which the Date of Grant falls; and

  

	 	(b)	capable of independent objective assessment with a view to determining whether they have been satisfied; and 

  

	 	(c)	set out in detail at the Date of Grant in the Option Agreement. 

  

	5.2	Different Exercise Conditions may be specified in respect of different numbers of the Shares comprised in the same Option. 

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	5.3	Subject to the provisions of these Rules where an Option has been granted subject to Exercise Conditions, the Board shall as soon as reasonably practicable following the satisfaction of any Exercise Conditions give
written notice to inform the Option Holder concerned that his Option has become exercisable subject always to the provisions of Rule 6. 

  

	5.4	Where events happen which cause the Board to consider that the Exercise Conditions are no longer appropriate, or the Board at its entire discretion so decides, it may: 

 

	 	(a)	vary the Exercise Conditions provided that the new Exercise Conditions are not more difficult to satisfy than the original Performance Conditions; or 

 

	 	(b)	remove the Exercise Conditions as a requirement of the exercise of the Option; 

 PROVIDED that
the Option Holder is given notice in writing of the variation or removal as soon as practicable. 
  

	6.	EXERCISE OF OPTION 

  

	6.1	An Option shall be exercised: – 

  

	 	(a)	pursuant to the terms of exercise set out in the Option Agreement; and 

  

	 	(b)	by lodging with the Company Secretary or such other person as the Board may specify, the relevant Option Agreement, a duly completed Notice of Exercise and (subject to Rule 8.6) the payment required in respect of the
Option Price and any Tax Liabilities and secondary NIC liability. 

  

	6.2	Lapse of Options 

 An Option shall cease to be exercisable and shall lapse forthwith on
the occurrence of the following events: – 
  

	 	(a)	5pm on the day before the tenth anniversary of the grant of the Option; 

  

	 	(b)	save in the case of (i) the death of the Option Holder; or (ii) as a result of the Option Holder being a Good Leaver, where the Option Holder has ceased to be an employee of the Company or of a Qualifying
Subsidiary and the relevant period stated in Rule 7.2 has expired without the Board giving direction otherwise; 

  

	 	(c)	the Option Holder does or suffers any act or thing (including bankruptcy) whereby he would or might be deprived of the legal or beneficial ownership of the Option; 

 

	 	(d)	the lapsing events referred to in Rules 4, 7, 8 and 9. 

  

	6.3	Result of Exercise of Options 

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	 	(a)	Subject to: 

  

	 	(i)	the obtaining of any necessary consent from H.M. Treasury, the Bank of England, the UK Listing Authority, the London Stock Exchange Plc or other relevant authority; 

 

	 	(ii)	the terms of any such consent; 

  

	 	(iii)	receipt by the Company of the appropriate payment for Shares to be acquired on exercise in full 

the Company shall (subject to Rule 8.7) within 30 days of receipt by the Company Secretary of a valid Notice of Exercise issue to or arrange
the transfer to the Option Holder the number of Shares in respect of which the Option has been exercised (but if during a Close Period such issue or transfer shall be effected as soon as reasonably practicable after the end of the Close Period).

  

	 	(b)	The Board shall at all times keep available sufficient unissued Shares or shall procure that there are available sufficient Shares to satisfy the exercise of all Options granted under the Scheme. For this purpose the
Board may enter into an agreement with any individual, company or the trustees of any employee benefit trust for the provision by such persons of Shares to satisfy Options. In such case, and if appropriate, the Option Price payable by the Option
Holder shall be received by a member of the Board as trustee for such persons (to whom it shall account) and the Board shall procure the transfer of Shares by such persons upon exercise of the Option. 

 

	 	(c)	All Shares issued on exercise of Options shall on issue rank equally in all respects with the Company’s existing Shares of the same class, save that the Shares issued under the Scheme will not rank for any
dividends or other distributions declared or recommended the record date for which falls on or prior to the date when the Option is exercised. 

  

	6.4	Tax Liability 

  

	 	(a)	It being a condition of the grant of an Option that each Option Holder indemnifies the Company and any other Group Member against Tax Liabilities and/or secondary NIC Liabilities (“Liabilities”) pursuant to
Rule 2.6(a), to the extent that the Liabilities cannot be (or are not) deducted from payments made by the Company or Group Member to the Option Holder, the Company shall be authorised by the Option Holder: – 

 

	 	(i)	to retain and sell on the Option Holder’s behalf sufficient Shares issued or acquired on exercise of the Option to raise the necessary funds to meet and to apply such funds in discharging the Liabilities or
reimbursing the Company or the relevant Group Member; and/or 

  

	 	(ii)	to make such other arrangements with the Option Holder in question as the Board deems appropriate for the reimbursement to the Company or relevant Group Member of the Liabilities. 

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	7.	LEAVER OR DEATH OF OPTION HOLDER 

 Subject to Rule 6.2 and subject to Rule 5:

  

	7.1	If an Option Holder dies before exercising an Option or part thereof, the Option may (and must, if at all) be exercised by his personal representatives to the extent that any Exercise Conditions have been met within the
period ending on the earlier of: 

  

	 	(a)	the expiry of 12 months after the date of death; and 

  

	 	(b)	the time referred to in Rule 6.2(a), 

 and failing such exercise the Option shall lapse. 

 

	7.2	Save (i) in the case of the Option Holders death (in which case Rule 7.1 applies); or (ii) where the Option Holder is a Good Leaver, if an Option Holder ceases to be an Eligible Employee of the Company or of a
Qualifying Subsidiary then any Option not exercised by the time of such cessation shall immediately cease to be exercisable and shall lapse 90 days after such cessation unless within 90 days after cessation the Board in its absolute discretion shall
permit the Option to be exercised in whole or in part within a specified period in which event the Option may be exercised by the Option Holder to the extent so permitted by the Board so long as it is prior to the time referred to in Rule 6.1(a),
and failing such exercise the Option shall lapse. 

  

	7.3	An Option Holder shall not be treated for the purposes of these Rules as ceasing employment until such time as he is no longer a director or employee of the Company or of any Qualifying Subsidiary and an Option Holder
(being a woman) who is absent from work by reason of pregnancy or confinement and who exercises her right to return to work under the Employment Rights Act 1996 before exercising an Option under the Scheme shall be treated for the purposes of these
Rules as not having ceased to be such an employee. 

  

	7.4	For the purposes of these Rules, where an Option Holder’s contract of employment with the Group is terminated by a Group Member without notice the Option Holder’s employment shall be deemed to cease on the
date on which the termination takes effect and where the said contract is terminated by notice given or received by a Group Member, the Option Holder’s employment shall be deemed to cease on the date on which that notice is served.

  

	7.5	Where an Option Holder ceases to be an Eligible Employee of the Company or of a Qualifying Subsidiary but notwithstanding that, the Option Holder remains entitled under these Rules to exercise the Options, then whilst
the Option granted to the Option Holder may, as a result of the Option Holder ceasing to be an Eligible Employee, cease to qualify for tax advantages pursuant to the EMI Code for the period following such cessation, the Option itself will not lapse
as a result of the Option Holder ceasing to be an Eligible Employee (save as otherwise provided for in these Rules). 

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	8.	CHANGE OF CONTROL, AND SALE OF THE COMPANY 

  

	8.1	Change of Control – If: 

  

	 	(a)	any person or group of persons acting in concert obtains Control of the Company as a result of making: 

  

	 	(i)	an offer to acquire more than 50% of the Capital of the Company which is made on a condition such that if it is satisfied the person or group of persons will have Control of the Company; or 

 

	 	(ii)	a general offer to acquire all the Capital (or all the shares which are of the same class of those to which the Option relates); or 

 

	 	(b)	any person becomes entitled or bound to acquire shares in the capital of the Company under Sections 428 to 430F of the Companies Act 1985; or 

 

	 	(c)	under Section 425 of the Companies Act 1985 the court sanctions a compromise or arrangement proposed for the purposes of or in connection with a scheme for the reconstruction of the Company or its amalgamation with
any other company or companies; 

 and if the Option Agreement allows for exercise of the Option on a Change of Control, an
Option Holder (or his personal representative) may at any time during the three days prior to or within the Appropriate Period, exercise any Option or part thereof which has not lapsed. Any Option which is not so exercised shall lapse at the expiry
of the Appropriate Period. 
  

	8.2	Replacement Options: 

  

	 	(a)	If a company (in this Rule called the “Acquiring Company”) has acquired Control of the Company as a result of any of the events described in Rule 8.1(a) or 8.1(c), or becomes entitled or bound as
mentioned in Rule 8.1(b) or obtains all the shares of the Company whose shares are subject to any outstanding Qualifying Options as a result of a qualifying exchange of shares (as defined in paragraph 40(1) Schedule 5) (such acquiring of Control or
becoming entitled or bound or obtains, being referred to below as a “Specific Event”), any Option Holder may by agreement with the Acquiring Company at any time within the Appropriate Period as defined in Rule 8.3 below release his
rights in respect of any EMI Option held by him (in this Rule referred to as the “Old Option”) in consideration of the grant to him of rights (in this Rule referred to as the “Replacement Option”) which are
equivalent and relate to shares in the Acquiring Company, and which comply with Rule 8.2(b). 

  

	 	(b)	A Replacement Option is one in relation to which the requirements of paragraph 43 of Schedule 5 are satisfied at the time of release of the Old Option including grant by reason of the Option Holder’s employment
with the Acquiring Company. 

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	8.3	“Appropriate Period” means: 

  

	 	(a)	in a case falling within Rule 8.1(a) and where Rule 8.1(b) does not apply, the period of six months beginning with the time when the person making the offer has obtained Control of the Company and any condition subject
to which the offer is made is satisfied; 

  

	 	(b)	in a case falling within Rule 8.1(b) the period during which the person remains bound or entitled as mentioned in that paragraph; and 

 

	 	(c)	in a case falling within Rule 8.1(c) the period of six months beginning with the time when the court sanctions the compromise or arrangement. 

 

	8.4	If a Replacement Option shall be granted to an Option Holder by reference to any Specific Event, Rules 8.1(a), 8.1(b) and 8.1(c) above shall cease to apply by reference to that Specific Event (but without prejudice to
their application by reference to any other Specific Event). Any EMI Option which is not exercised or released pursuant to this Rule within the Appropriate Period following a Specific Event (but not any Replacement Option granted by reference to
that Specific Event) shall lapse. 

  

	8.5	Sale: If the Option Agreement allows for exercise of the Option on a Sale, in the event that the Board becomes aware that there may be a Sale of the Company they shall give notice (a “Sale
Notice”) in writing to the Option Holder specifying that a Sale may be forthcoming and that the Option will lapse immediately following the sale if not exercised prior to completion of the Sale unless a Replacement Option is offered to the
Option Holder in accordance with Clause 8.2 (or unless some other form of replacement option is offered by the prospective purchaser). 

  

	8.6	At any time after receipt of a Sale Notice under Clause 8.5 and prior to completion of the Sale, the Option Holder may exercise the Option in accordance with Clause 6 but only on the basis that the Option Holder agrees
to sell to the purchaser on completion of the Sale all the Shares acquired as a result of the exercise of the Option. Any such Exercise Notice from the Option Holder shall be accompanied by a cheque for the aggregate Option Price but shall specify
the number of Shares over which the Option Holder wishes to exercise his Option, and any such notice may not be withdrawn without the consent of the Board. 

  

	8.7	Completion of the subscription for, or transfer of, the Shares shall take place prior to completion of the Sale and the Company shall issue and allot the relevant Shares in favour of the Option Holder and shall register
such issue and allotment or transfer prior to completion of the Sale. 

  

	8.8	In the event that the Sale proceeds are received directly by the Option Holder, the Option Holder undertakes to reimburse the Company (or any other Group Company) for a sum equal to the aggregate Option Price, along
with any Tax liabilities and/or secondary NIC Liability that may be due in relation to the exercise of the Option, whether by deduction under clause 6.4 or otherwise. 

 

	8.9	Clauses 8.5 to 8.8 above dealing with a Sale shall take priority over Clause 8.1 dealing with other forms of Change of Control and for the avoidance of doubt in the event of a Sale, Clause 8.1 will not apply but clauses
8.2 to 8.4 may apply. 

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	9.	WINDING-UP OF THE COMPANY 

  

	9.1	If at any time while any Option remains unexercised notice is duly given of a general meeting of the Company at which a resolution will be proposed for the voluntary liquidation of the Company, every Option which has
not lapsed prior to such resolution shall be exercisable in whole or in part until the commencement of such winding-up within the meaning of Section 86 of the Insolvency Act 1986. 

 

	9.2	Pursuant to the above Rule 9.1 the Company shall give to each Option Holder holding any unexercised Option notice of any meeting called for the purpose of considering a resolution for the voluntary liquidation of the
Company and shall at the same time give him notice of his rights under this Rule 9 and subject to the foregoing, all Options shall lapse on the commencement of any liquidation of the Company. 

 

	10.	VARIATION OF CAPITAL 

  

	10.1	Subject to Rules 10.3 and 10.4 below, in the event of any increase or variation of the Capital (whenever effected) by way of capitalisation or rights issue, or sub-division,
consolidation or reduction, the Board may make such adjustments as they consider appropriate under Rule 10.2 below. 

  

	10.2	An adjustment made under this Rule 10 shall be to one or more of the following: 

  

	 	(a)	the number of Shares in respect of which any Option granted under the Scheme may be exercised; 

  

	 	(b)	the price at which shares may be acquired by the exercise of any such Option; 

  

	 	(c)	where any such Option has been exercised but no Shares have been transferred pursuant to such exercise, the number of Shares which may be so transferred and the price at which they may be acquired. 

 

	10.3	Except in the case of a capitalisation issue, no adjustment under Rule 10.2 above shall be made without the prior confirmation in writing by the Auditors or other share valuers to the Board that it is in their opinion
fair and reasonable. 

  

	10.4	No adjustment under Rule 10.2 above shall be made 

  

	 	(a)	which would affect EMI Options which are Qualifying Options without the prior approval of HM Revenue and Customs if so required; 

  

	 	(b)	as a result of which the aggregate amount payable on the exercise of an Option in full would be increased or reduced. 

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	10.5	An adjustment under Rule 10.2 above may have the effect of reducing the price at which Shares may be acquired by the exercise of the Option to less than their nominal value, but only if and to the extent that the Board
shall be authorised to capitalise from the reserves of the Company a sum equal to the amount by which the nominal value of the Shares in respect of which the Option is exercised and which are to be allotted pursuant to such exercise exceeds the
price at which the same may be subscribed for, and to apply such sum in paying up such amount on such Shares, and so that on exercise of any Option in respect of which such a reduction shall have been made, the Board shall capitalise such sum (if
any) and apply the same in paying up such amount as aforesaid. 

  

	10.6	As soon as reasonably practicable after making any adjustment under Rule 10.2 above, the Board shall give notice in writing thereof to each Option Holder. 

 

	11.	ALTERATIONS TO THE RULES 

  

	11.1	The Board may by resolution at any time make any alteration to the Rules which it thinks fit subject to the provisions of this Rule 11. 

 

	11.2	No such alteration which would affect an EMI Option which is a Qualifying Option shall take effect if the result would be: 

  

	 	(a)	to increase the aggregate Market Value of the Shares that are the subject of such Qualifying Option; or 

  

	 	(b)	that the requirements of Schedule 5 would cease to be met in relation to such EMI Option. 

  

	11.3	No alteration shall be made which would materially increase the liability of any Option Holder or which would materially decrease the value of his subsisting rights attached to any Option without in each case that
Option Holder’s prior written consent. 

  

	11.4	No alteration shall take effect without the prior approval of the Company in general meeting (except for minor amendments to benefit administration of the Scheme, to comply with or to take account of any applicable
legislation or statutory regulations or any change therein or any requirements of HM Revenue and Customs for the approval of the Scheme under any such legislation or regulations or to obtain or maintain favourable taxation treatment for the Company
or the Option Holders or potential Option Holders). 

  

	11.5	As soon as reasonably practicable after making any alteration under Rule 11.1 above the Board shall give notice in writing thereof to each Option Holder. 

 

	12.	MISCELLANEOUS 

  

	12.1	 Any Option granted pursuant to the Rules shall not form part of the contract of employment of any person who
participates in the Scheme. The rights and obligations of any individual under the terms of his office or employment with any Group Member shall not be affected by his 

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participation in the Scheme or any right which he may have to participate therein, and an individual who participates therein shall waive any and all rights to compensation or damages in
consequence of the termination of his office or employment for any reason whatsoever (including unfair or wrongful dismissal) insofar as those rights arise or may arise from his ceasing to have rights under or be entitled to exercise any Option
under the Scheme as a result of such termination. No such participation, rights or benefits shall be taken into account for the purposes of calculating the amount payable to any pension fund. Options granted pursuant to the Scheme shall not
constitute any representation or warranty that any benefit will accrue to any individual who is granted an Option. 

  

	12.2	The Scheme shall in all respects be administered by the Board who may from time to time make and vary such rules and regulations for its conduct not inconsistent with these Rules and may from time to time establish such
procedures for administration and implementation of the Scheme and Rules as it thinks fit, and in the event of any dispute or disagreement as to the interpretation of the Rules, or of any rule, regulation or procedure, or as to any question or right
arising from or related to the Scheme, the decision of the Board shall be final and binding upon all persons (subject to the written concurrence of the Auditors having been obtained when so required by the Rules). 

 

	12.3	Any Group Member may provide money to the trustees of any trust or any other person to enable them or him to acquire shares to be held for the purposes of the Scheme, or enter into any guarantee or indemnity for these
purposes, to the extent permitted by section 153 of the Companies Act 1985. 

  

	12.4	In any matter in which they are required to act under the Rules, the Auditors shall be deemed to be acting as experts and not as arbitrators and the Arbitration Acts 1950 to 1996 shall not apply to these Rules.

  

	12.5	Any notice or other communication under or in connection with the Rules may be given by personal delivery or by sending the same by post, in the case of a company to its registered office and in the case of an
individual to his last known address, or, where he is a director or employee of a Company participating in the Scheme, either to his last known address or to the address of the place of business at which he performs the whole or substantially the
whole of the duties of his office or employment, and where a notice or other communication is given by first-class post, it shall be deemed to have been received 48 hours after it was put into the post properly addressed and stamped.

  

	12.6	The costs of introducing and administering the Scheme shall be borne by the Company or any Group Member. 

  

	12.7	The Board shall maintain all necessary books of account and records relating to the Scheme. 

  

	12.8	Subject to the Articles of Association of the Company, an Option Holder who is a director of the Company may, notwithstanding his interest, vote on any resolution concerning the Scheme (other than in respect of his own
participation therein) and may retain any benefits under the Scheme. 

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	13.	GOVERNING LAW 

 The Rules and the Scheme shall in all respects be governed by the
laws of England. 

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 Form of Option Agreement 

This Agreement which is in the form of a deed is made the day
of                 200● 
 BETWEEN 

 

	(1)	NuCana Biomed Limited (03308778 ) whose registered office is at Butler & Co Accountants, 5 Southwell Park Road, Camberley, Surrey, GU15 3PU (“Company”); and 

 

	(2)	[option holders name] of [option holders address] who will become “the Option Holder” 

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 RECITALS 
  

	A.	This Unapproved Option is granted subject to the rules of the                2012 NuCana Biomed Limited Share Option Scheme
(“Scheme”). 

  

	B.	A copy of the rules which is appended to this Agreement provides for the grant of options for commercial reasons in order to recruit and retain key employees and/or directors (“Rules”).

 NOW THIS AGREEMENT WITNESSES 
  

	1.	In this Agreement the definitions in the Rules shall apply. 

  

	2.	The Company hereby grants to the Option Holder the Unapproved Option to acquire a maximum of [                ] Shares, at an Option Price
of * per Share. 

  

	3	Exercise  

  

	 	3.1	The options shall be exercisable as follows: 

  

	 	•	 	X options may be exercised at any time after 12 months from the date of grant 

  

	 	•	 	a further X options may be exercised at any time after 24 months from the date of grant 

  

	 	•	 	the final X options may be exercised at any time after 36 months from the date of grant 

  

	 	3.2	All unexercised options will also be able to be exercised on the occasion of Admission, a change of control, or sale of the company. 

 

	4.	The Unapproved Option may not be exercised: 

  

	 	4.1	after the time in Rule 6.2(a); 

  

	 	4.2	from the date the Option Holder ceases to be an employee or director of the Company or of any Qualifying Subsidiary in accordance with Rule 6.2 (b) (except to the extent provided in Rule 6.2 (b) and Rule 7);

  

	 	4.3	following a Change of Control or a Sale of the Company except to the extent provided in Rule 8; 

  

	 	4.4	following the commencement of the winding up of the Company as set out in Rule 9. 

  

	5.	The Unapproved Option will lapse on the occurrence of any of the events as set out in Rule 6.2. 

  

	6.	To exercise the Unapproved Option the Option Holder must lodge with the Company Secretary of the Company (or such other person as the Company may from time to time notify to the Option Holder in writing):

  

	 	6.1	this Option Agreement; 

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	 	6.2	a duly completed Notice of Exercise in the form appended to this Option Agreement; 

  

	 	6.3	where required by the Company, a duly completed Joint Election; and 

  

	 	6.4	a cheque made payable to the Company in respect of the Option Price. 

  

	7.	The Option Holder hereby: 

  

	7.1	covenants with the Company to allow the Company to recover from the Option Holder Tax Liabilities arising in connection with or as a result of the exercise of the Unapproved Option and to indemnify and keep
indemnified on a continuing basis the Company and any Group Member in respect of such Tax Liabilities and for the purposes of such indemnity: 

  

	7.2	hereby authorises the Company to deduct sufficient funds which, in the reasonable opinion of the Board, would be equal to any Tax Liabilities from any payment made to or in respect of the Option Holder by it or any
Group Member during the same calendar month or other relevant period in which such Tax Liabilities arise. If there is no such payment made or the Tax Liabilities exceed the amount of such payment the Option Holder hereby agrees to pay the full
amount of the Tax Liabilities or any such excess (as the case may be) in cleared funds within seven days of a valid demand by the Company or any Group Member; and 

 

	7.3	appoints a member of the Board as his [trustee] for the purposes of providing the Company or any Group Member (as appropriate) with sufficient funds to recover any Tax Liabilities by receiving on trust or retaining on
trust (as the case may be) (out of the total number of Shares to which the Option Holder is entitled following the relevant exercise of the Unapproved Option) the legal title to and selling such number of Shares as, in the reasonable opinion of the
Board, is required to realise a cash amount equivalent to the Tax Liabilities and the Option Holder hereby covenants to pay to the Company, should such sale realise a cash amount less than the Tax Liabilities, an amount equal to the difference
within seven working days of demand by the Company. 

  

	8.	The Unapproved Option is exercisable only by the Option Holder (or his personal representatives) and may not be transferred, assigned or charged and the Unapproved Option will lapse on the occasion of any assignment,
charge, disposal or other dealing with the rights conveyed by it. 

  

	9.	The Company has agreed or will agree the Market Value of a Share for the purposes of this Scheme as at the Date of Grant with HM Revenue and Customs. 

 

	10.	A person who is not a party to this deed shall have no right under the Contracts (Rights of Third Parties) Act 1999 to enforce any term of this deed. This clause does not affect any right or remedy of any person which
exists or is available otherwise than pursuant to that Act. 

  

	11.	The Shares which will be acquired when the Option is exercised are subject to the terms and restrictions set out in the Company’s articles of association, and a copy of the current articles of association is
attached. 

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 APPENDIX 

Form of Notice of Exercise 

Please read the notes at the foot of his form carefully before completing it 

 

	To:	The Secretary 
NuCana Biomed Limited 

 I, the
undersigned1, having become entitled so to do, hereby exercise the Unapproved Option referred to in the attached Agreement in respect of Shares comprised in the Unapproved Option upon the terms of
the 2012 NuCana Biomed Limited Share Option Scheme (“Scheme”) and agree to accept the Shares to be allotted and issued pursuant to this Notice of Exercise subject to and in accordance with the memorandum and articles of association
of the Company and hereby request you to place my name on the register of members in respect thereof. 
 I enclose a remittance for £2 being the aggregate Option Price payable for the Shares in respect of which the Unapproved Option is now exercised, the Option Price (per Share) being
[                ]. 
 I understand that income tax and NIC (referred to as
a Tax Liabilities in the Rules of the Scheme) may need to be accounted for by the Company to HM Revenue and Customs on this exercise and in respect of which I have indemnified the Company. I further understand that the Company has an obligation to
deduct, insofar as possible, the amount of any Tax Liabilities from payments that it makes to me and I authorise the Company to make such deductions from my salary. 

(please tick as appropriate3) 

 

	☐	I wish to make a cash payment to the Company in respect of the outstanding Tax Liabilities (after deduction by the Company) arising from this exercise and enclose a second cheque made payable to the Company for
£●. 

  

	☐	I authorise the Company to retain and to sell on my behalf sufficient Shares so as to realise an amount sufficient to discharge the Tax Liabilities arising from this exercise. 

If applicable, I hereby request you to despatch a balance certificate for the Unapproved Option to subscribe for any Shares included in the Unapproved Option
referred to overleaf and not exercised on this occasion, by post at my risk to the address mentioned below. 
  

									
	Signature:	 	 	 		 	Date:	 	 
					
	Surname:	 	 	 		 		 	
					
	Forename(s):	 	 	 		 		 	
					
	Address:	 	 	 		 		 	
		 	 	 		 		 	
		 	 	 		 		 	
		 	 	 		 		 	

 [If the shares are restricted under ITEPA the Option Holder should be required to enter into a Joint Election with the
Company to which this Exercise Notice should refer.] 
  

	1 	Although the Option referred to overleaf is personal to the holder named overleaf it may be exercised by his personal representative(s) if he dies while the Option is still capable of exercise provided the
personal representative(s) does/do so before the expiration of 12 months from the date of the Option Holder’s death or 10 years from the date of its grant (if sooner). If there are more than one, each of the personal representatives must sign
this form. A copy of the Grant of Probate must be provided with the completed Notice of Exercise. 

	2 	The remittance should be for an amount equal to the Option Price per Share shown overleaf, multiplied by the number of Shares applied for. 

	3 	Please tick the appropriate box. If you fail to tick a box or if you tick the first box but your cash payment or next month’s salary are insufficient to cover the full liability, the Company will retain and sell
sufficient shares to cover the liability or shortfall or will withhold the transferring of the shares to you until the full tax liabilities have been met by you. 

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 In Witness whereof the parties have signed this Agreement on the date specified above: 

 

	 EXECUTED as a DEED 
	) 

	 but not delivered until the date hereof 
	) 

	 for and on behalf of THE COMPANY 
	) 

 Director 

Director/Secretary 
  

	 SIGNED as a DEED  
	) 

	 but not delivered until the date hereof 
	) 

	 by ● 
	) 

	 in the presence of: 
	) 

  

			
	Name of Witness	 	 
	Address	 	 
		 	 
		 	 
		 	 

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 Form of Option Agreement 

This Agreement which is in the form of a deed is made the day of
                 200● 
 BETWEEN 

 

	(1)	NuCana Biomed Limited (03308778 ) whose registered office is at Butler & Co Accountants, 5 Southwell Park Road, Camberley, Surrey, GU15 3PU (“Company”); and 

 

	(2)	[employee name] of [employee address] who will become “the Option Holder” 

 RECITALS 

 

	A.	This EMI Option is granted subject to the rules of the                  2012 NuCana Biomed Limited Share Option Scheme, and is granted
pursuant to Schedule 5 ITEPA 2003 (“Scheme”). 

  

	B.	A copy of the rules which is appended to this Agreement provides for the grant of options for commercial reasons in order to recruit and retain key employees (“Rules”). 

NOW THIS AGREEMENT WITNESSES 
  

	1.	In this Agreement the definitions in the Rules shall apply. 

  

	2.	The Company hereby grants to the Option Holder the EMI Option to acquire a maximum of [                ] Shares, at an Option Price of *
per Share. 

  

	3	Exercise  

  

	 	3.3	The options shall be exercisable as follows: 

  

	 	•	 	X options may be exercised at any time after 12 months from the date of grant 

  

	 	•	 	a further X options may be exercised at any time after 24 months from the date of grant 

  

	 	•	 	the final X options may be exercised at any time after 36 months from the date of grant 

  

	 	3.4	All unexercised options will also be able to be exercised on the occasion of Admission, a change of control, or sale of the company. 

 

	4.	The EMI Option may not be exercised: 

  

	 	4.1	after the time in Rule 6.2(a); 

  

	 	4.2	from the date the Option Holder ceases to be an employee of the Company or of any Qualifying Subsidiary in accordance with Rule 6.2 (b) (except to the extent provided in Rule 6.2 (b) and Rule 7); 

 

	 	4.3	following a Change of Control or a Sale of the Company except to the extent provided in Rule 8; 

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	 	4.4	following the commencement of the winding up of the Company as set out in Rule 9. 

  

	5.	The EMI Option will lapse on the occurrence of any of the events as set out in Rule 6.2. 

  

	6.	To exercise the EMI Option the Option Holder must lodge with the Company Secretary of the Company (or such other person as the Company may from time to time notify to the employee in writing): 

 

	 	6.1	this Option Agreement; 

  

	 	6.2	a duly completed Notice of Exercise in the form appended to this Option Agreement; 

  

	 	6.3	where required by the Company, a duly completed Joint Election; and 

  

	 	6.4	a cheque made payable to the Company in respect of the Option Price. 

  

	7.	The employee hereby: 

  

	7.1	covenants with the Company to allow the Company to recover from the Option Holder Tax Liabilities arising in connection with or as a result of the exercise of the EMI Option and to indemnify and keep indemnified
on a continuing basis the Company and any Group Member in respect of such Tax Liabilities and for the purposes of such indemnity: 

  

	7.2	hereby authorises the Company to deduct sufficient funds which, in the reasonable opinion of the Board, would be equal to any Tax Liabilities from any payment made to or in respect of the Option Holder by it or any
Group Member during the same calendar month or other relevant period in which such Tax Liabilities arise. If there is no such payment made or the Tax Liabilities exceed the amount of such payment the Option Holder hereby agrees to pay the full
amount of the Tax Liabilities or any such excess (as the case may be) in cleared funds within seven days of a valid demand by the Company or any Group Member; and 

 

	7.3	appoints a member of the Board as his trustee for the purposes of providing the Company or any Group Member (as appropriate) with sufficient funds to recover any Tax Liabilities by receiving on trust or retaining on
trust (as the case may be) (out of the total number of Shares to which the Option Holder is entitled following the relevant exercise of the EMI Option) the legal title to and selling such number of Shares as, in the reasonable opinion of the Board,
is required to realise a cash amount equivalent to the Tax Liabilities and the Option Holder hereby covenants to pay to the Company, should such sale realise a cash amount less than the Tax Liabilities, an amount equal to the difference within seven
working days of demand by the Company. 

  

	8.	The EMI Option is exercisable only by the Option Holder (or his personal representatives) and may not be transferred, assigned or charged and the EMI Option will lapse on the occasion of any assignment, charge, disposal
or other dealing with the rights conveyed by it. 

  

	9.	The Company has agreed or will agree the Market Value of a Share for the purposes of this Scheme as at the Date of Grant with HM Revenue and Customs. 

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	10.	A person who is not a party to this deed shall have no right under the Contracts (Rights of Third Parties) Act 1999 to enforce any term of this deed. This clause does not affect any right or remedy of any person which
exists or is available otherwise than pursuant to that Act. 

  

	11.	The Shares which will be acquired when the Option is exercised are subject to the terms and restrictions set out in the Company’s articles of association, and a copy of the current articles of association is
attached. 

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 APPENDIX 

Form of Notice of Exercise 

Please read the notes at the foot of his form carefully before completing it 

 

	To:	The Secretary 

	    	NuCana Biomed Limited 

 I, the undersigned4, having become
entitled so to do, hereby exercise the EMI Option referred to in the attached Agreement in respect of Shares comprised in the EMI Option upon the terms of the NuCana Biomed Limited Share Option Scheme (“Scheme”) and agree to accept
the Shares to be allotted and issued pursuant to this Notice of Exercise subject to and in accordance with the memorandum and articles of association of the Company and hereby request you to place my name on the register of members in respect
thereof. 
 I enclose a remittance for £5 being the aggregate Option Price payable for the Shares
in respect of which the EMI Option is now exercised, the Option Price (per Share) being [                ]. 

I understand that income tax and NIC (referred to as a Tax Liabilities in the Rules of the Scheme) may need to be accounted for by the Company to HM Revenue
and Customs on this exercise and in respect of which I have indemnified the Company. I further understand that the Company has an obligation to deduct, insofar as possible, the amount of any Tax Liabilities from payments that it makes to me and I
authorise the Company to make such deductions from my salary. 
 (please tick as appropriate6)

  

	☐	I wish to make a cash payment to the Company in respect of the outstanding Tax Liabilities (after deduction by the Company) arising from this exercise and enclose a second cheque made payable to the Company for
£●. 

  

	☐	I authorise the Company to retain and to sell on my behalf sufficient Shares so as to realise an amount sufficient to discharge the Tax Liabilities arising from this exercise. 

If applicable, I hereby request you to despatch a balance certificate for the EMI Option to subscribe for any Shares included in the EMI Option referred to
overleaf and not exercised on this occasion, by post at my risk to the address mentioned below. 
  

									
	Signature:	 	 	 		 	Date:	 	 
					
	Surname:	 	 	 		 		 	
					
	Forename(s):	 	 	 		 		 	
					
	Address:	 	 	 		 		 	
		 	 	 		 		 	
		 	 	 		 		 	
		 	 	 		 		 	

 [If the shares are restricted under ITEPA the Option Holder should be required to enter into a Joint Election with the
Company to which this Exercise Notice should refer.] 
  

	4 	Although the Option referred to overleaf is personal to the holder named overleaf it may be exercised by his personal representative(s) if he dies while the Option is still capable of exercise provided the
personal representative(s) does/do so before the expiration of 12 months from the date of the Option Holder’s death or 10 years from the date of its grant (if sooner). If there are more than one, each of the personal representatives must sign
this form. A copy of the Grant of Probate must be provided with the completed Notice of Exercise. 

	5 	The remittance should be for an amount equal to the Option Price per Share shown overleaf, multiplied by the number of Shares applied for. 

	6 	Please tick the appropriate box. If you fail to tick a box or if you tick the first box but your cash payment or next month’s salary are insufficient to cover the full liability, the Company will retain and sell
sufficient shares to cover the liability or shortfall or will withhold the transferring of the shares to you until the full tax liabilities have been met by you. 

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 In Witness whereof the parties have signed this Agreement on the date specified above: 

 

	 EXECUTED as a DEED 
	) 

	 but not delivered until the date hereof 
	) 

	 for and on behalf of THE COMPANY 
	) 

 Director 

Director/Secretary 
  

	 SIGNED as a DEED  
	) 

	 but not delivered until the date hereof 
	) 

	 by ● 
	) 

	 in the presence of: 
	) 

  

			
	Name of Witness	 	 
	Address

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