Document:

Lease Agreement

 Exhibit 10.2 
 LEASE 
 THIS LEASE (“Lease”) is made
and entered into as of the 17th day of August, 2007, by and between, Marco Island Radiation Enterprise, LLC whose business address is 2234 Colonial Blvd. Fort Myers, FL 33907 (“Landlord”), and 21st Century Oncology, Inc. whose business address is 2234 Colonial Blvd. Fort Myers, FL 33907 (“Tenant”). 
 WITNESSETH : 
 ARTICLE 1 
 TERMS 
 1.1 Premises. Landlord
hereby demises and leases to Tenant and Tenant hereby hires and rents from Landlord the premises located at 8625 Collier Blvd. Naples, FL 34114-3550, and more particularly described in Exhibit “A” to this Agreement (“Premises”)
upon the terms, covenants and conditions set forth herein, which Premises has a floor area containing the approximate square footage of 6,877 square feet. 
 1.2 Use. The Premises are to be used for a medical office and radiation therapy center and ancillary services. 
 1.3 Commencement of Term. The commencement of the Term of this Lease under which Tenant shall be obligated to commence payment of Minimum Rent and Additional Rent shall be on or about the 17th day of August,
2007 (“Commencement Date”). 
 1.4 Length of the Term. The term of this lease period is for Ten years (10) years
(“Term”). The starting date of this lease is the Commencement Date and, unless this Lease is renewed in accordance with Article 4 below, the ending date is on or about the 16th day of August, 2027 (“Expiration Date”). 

ARTICLE 2 
 RENT 

2.1 Rent. Minimum rent shall be Thirty Seven Thousand Two Hundred Sixteen Dollars and Sixty-Seven Cents (37,216.67) per month
(“Minimum Rent”). Tenant shall pay to Landlord without previous demand thereof and without any abatement, reduction, setoff or deduction whatsoever, the Minimum Rent (together with any applicable sales tax and local taxes if the same are
ever required by law), payable in equal monthly installments, in advance, on the first day of each and every calendar month throughout the Term of this Lease. The Minimum Rent shall commence to accrue on the Commencement Date. The first such monthly
installments of Minimum Rent shall be due and payable to Landlord no later than the Commencement Date and each subsequent monthly installment shall be due and payable to Landlord on the first day of each and every calendar month following the
Commencement Date during the Term hereof. If the Commencement Date is a date other than the first day of the month, Minimum Rent and other charges for the period commencing with and including the Commencement Date through the first day of the
following month shall be prorated at the rate of one-thirtieth (1/30) of the monthly Minimum Rent per day. 
 In addition, Tenant shall
pay as Additional Rent monthly payments of applicable taxes, assessments and insurance on the Premises. This amount will be 1/12 of the bill for annual real 

 
estate and assessment taxes and 1/12 of the annual bill on insurance. Estimated figures for taxes and insurance monthly rate will be produced within ten
(10) days after the signing of this Lease. Each year Landlord will produce any insurance, real estate tax and assessment bills to the Tenant to show how the estimated taxes and insurance were computed as Additional Rent. In the event of any
overage or underage due to the actual amounts owed and the payments made based on the estimated amounts during any Lease year, Landlord shall reimburse to Tenant the amount of any overage paid by Tenant or Tenant shall pay to Landlord the amount of
any underage due from Tenant in either case within thirty (30) days of the delivery of the bills to Tenant as herein provided. 
 2.1.1
There will be an increase in the Minimum Rent starting on the first anniversary of the lease if the Consumer Price Index increases over the immediately preceding year. Minimum Rent specified in this lease shall be subject to increase in accordance
with changes in the Consumer Price Index for Urban Wage Earners and Clerical Workers (CPI-W) as promulgated by the Bureau of Labor Statistics of the United States Department of Labor, using the year of the Commencement Date as a base of 100. On each
anniversary date there will be a rent adjustment based on the percentage increase in the Consumer Price Index from the immediately preceding year. If the Consumer Price Index goes down the rent will not change for that year. Consumer Price Index
increases will apply on the anniversary date of each year of the Commencement Date. The percentage increase in the Consumer Price Index will increase the minimum rent for that year. 
 2.1.2 In the event that the Consumer Price Index ceases to incorporate significant number of items, or if a substantial change is made in the method of
establishing such Consumer Price Index shall be adjusted to the figure that would have resulted had no change occurred in the manner of computing such Consumer Price Index, or a successor or substitute index, is not available, a reliable
governmental or other nonpartisan publication, evaluating the information for use in determining the Consumer Price Index, shall be used in lieu of such Consumer Price Index. 
 2.2 Late Charge. Tenant shall pay to Landlord a late charge equal to five percent (5%) of the monthly payment of Minimum Rent, Additional
Rent and any other payment or charge due hereunder if any such amount is received by Landlord more than five (5) days after the same shall be due, such amount being the agreed upon liquidated damages solely to defray the additional
administrative expenses incurred by Landlord in processing such payment. 
 2.3 Interest on Past Due Rent. If Tenant shall fail to
pay, when the same is due and payable, Minimum Rent, or Additional Rent, such unpaid amounts shall bear interest from the due date thereof to the date of payment, at the prime interest rate of the Chase Manhattan Bank, N.A. as of such due date, plus
Fifteen percent (15%) (“Default Date”). 
 2.4 Definition of Rent. The term “Rent” shall refer collectively
to Minimum Rent and Additional Rent. The term “Additional Rent” is sometimes used herein to refer to any and all other sums payable by Tenant hereunder, including, but not limited to, parking charges and sums payable on account of default
by Tenant. All Rent shall be paid by Tenant without offset, demand or other credit, and shall be payable only in lawful money of the United States of America which shall be legal tender in payment of all debts and dues, public and private, at the
time of payment. All sums payable by Tenant hereunder by check shall be obtained against a financial institution located in the United States of America. The rent shall be paid by Tenant at 2234 Colonial Blvd. Fort Myers, FL 33907. 

 2.5 Rent Taxes. In addition to Minimum Rent and Additional Rent, Tenant shall and hereby agrees to
pay to Landlord each month a sum equal to any sales tax, tax on rentals and any other similar charges now existing or hereafter imposed, based upon the privilege of leasing the space leased hereunder or based upon the amount of rent collected
therefor. 
 ARTICLE 3 
 NET LEASE 
 3.1 Net Lease. This Lease shall be deemed and construed to be a triple net lease and, except as herein
otherwise expressly provided, the Landlord shall receive the fixed Minimum Rent and Additional Rent and all other payments hereunder to be made by the Tenant absolutely free from any charges, assessments, imposition, expenses or deductions of any
kind and every kind or nature whatsoever. Tenant is to pay for all real estate taxes and assessments and any and all taxes of any nature applicable to the Premises. Tenant is to pay for all insurance and any and all costs for repairs, replacements,
maintenance and improvements. Tenant will also pay its pro rata share of any and all expenses for common areas, utilities, and association fees, if any. Tenant also is responsible for: 
 3.1.1 It’s proportionate share of any parking lot repairs, maintenance and replacements. 
 3.1.2 Any security, pest control or contrasts for air conditioner and cleaning services, etc. for it’s demised space. 
 ARTICLE 4 
 OPTION TO RENEW

 4.1 Option to Renew. Provided that Tenant is not then in default under any of the covenants, terms, conditions, and provisions
of this Lease, then Tenant shall have Two (2) options to renew this Lease (each an “Option”) for consecutive Ten (10) year option periods, provided that, in order to exercise this Option, Tenant is required to give to Landlord
written notice thereof not less than Six (6) months before nor more than Nine (9) months prior to the date of expiration of the Term of this Lease or the then expiring option period. Other than Base Rent due under the Option Term(s), any
renewal pursuant to this Option shall be on the same terms and conditions as contained in this Lease. 
 4.1.1 In the event that Tenant
exercises its option to extend the term of this lease, the Landlord shall provide written notice to Tenant of the amount which, in Landlord’s reasonable opinion, represents the Fair Market Rent for the upcoming Option Term. Tenant shall have
twenty (20) days from receipt of said written notice to respond to Landlord in writing as to whether or not Tenant agrees with Landlord’s determination of the Fair Market Rent. Tenant’s failure to respond within said twenty
(20) day period shall be deemed to be Tenant’s agreement with the Landlord’s determination of Base Rent. In the event Tenant disagrees with the Landlord’s determination, the following procedure shall be used in determining Fair
Market Rent for the Option Term: 
 The parties shall jointly choose an impartial real estate appraiser who shall review the market
comparables and provide a written assessment of the Fair Market Rent for the Premises. This written assessment shall determine the Base Rent for the Option Term and shall be final and binding; however, under no circumstance will the Base Rent for
the Option Term be less than the Base Rent for then current Lease year. 

 4.1.2 In the event that Landlord and Tenant cannot agree on an impartial real estate appraiser within
Sixty (60) days of Tenant’s notice of dissent, or if the mutually selected real estate appraiser cannot provide a written assessment within Forty-Five (45) days of Landlord and Tenant’s joint request, either the Tenant or
Landlord may terminate the Lease by providing written notice to the other, failing which, this Lease shall become a month-to-month lease upon the expiration of the current Lease term. 
 ARTICLE 5 
 INSURANCE AND INDEMNITY 
 5.1 Landlord’s Insurance. At all times during the Term, Landlord will carry and maintain: 
 (a) Fire and extended coverage insurance covering the Building in which the Premises is located, its equipment, and the Common Areas; 
 (b) Bodily injury and property damage insurance; and 
 (c) Such other insurance as Landlord reasonably determines from time to time. 
 The insurance coverage and
amounts in this Section 5.1 will be determined by Landlord, based on coverages carried by prudent owners of comparable buildings in the vicinity of the Premises. 
 5.2 Tenant’s Insurance. At all times during the Term, Tenant will carry and maintain, at Tenant’s expense, on an occurrence basis, the following insurance, in the amounts and on the forms specified
below or such other amounts and on such other forms as Landlord may from time to time reasonably request, with insurance companies satisfactory to Landlord: 
 (a) Bodily injury to or personal injury to or death of any person, or more than one (1) person, or for damage to property in an amount of not less than $1 million combined single limit each Occurrence/General
Aggregate and including a per location General Aggregate endorsement. All such insurance will be written on the most current occurrence ISO Commercial General Liability Form including without limitation, personal injury and contractual liability
coverage for the performance by Tenant of the indemnity agreements set for in this Lease, which insurance shall include a waiver of subrogation rights in favor of Landlord; 
 (b) Insurance covering all of Tenant’s furniture and fixtures, machinery, equipment, and any other personal property owned and used in Tenant’s
business and found in, on, or about the Premises, and any leasehold improvements to the Premises in an amount not less 

 
than the full replacement cost under Standard Fire and Extended Coverage Policy and all other risks of direct physical loss as insured against under Special
Form (“all risk of direct physical loss” coverage). All such insurance will be written on the most current ISO Commercial Property Form. All policy proceeds will be used for the repair or replacement of the property damaged or destroyed;
except, however, if this Lease ceases under the provisions of Article 15, Tenant will be entitled to any proceeds resulting from damage to Tenant’s furniture and fixtures, machinery, equipment, and any other personal property; 
 (c) Worker’s compensation insurance insuring against and satisfying Tenant’s obligations and liabilities under the worker’s compensation
laws of the State/Commonwealth of Florida, and Employer’s Liability Insurance in the limits required by the laws of the State/Commonwealth of Florida but in an amount not less than $500,000.00 aggregate; 
 (d) Such other insurance (including without limitation plate glass insurance), in such amounts as Landlord or its lender may reasonably require of Tenant
upon thirty (30) days’ prior written notice. 
 5.3 Forms of Policies. All policies of liability insurance which Tenant is
obligated to maintain according to this Lease (other than any policy of worker’s compensation insurance) will name Landlord and such other persons or firms as Landlord specifies from time to time as additional named insureds. Original or copies
of original policies and certificates of insurance on the most current ACORD form (together with copies of the endorsements naming Landlord and any others specified by Landlord as additional insureds) and evidence of the payment of all premiums of
such policies will be delivered to Landlord prior to the earlier of the Commencement Date or Tenant’s occupancy of the Premises and from time to time at least thirty (30) days prior to the expiration of the term of each such policy.
Tenant’s insurer shall have a Best Rating of at least A and be assigned a financial size category of at least Class X as rated in the most recent edition of “Best’s Key Rating Guide” for insurance companies. All liability
policies maintained by Tenant will contain a provision that Landlord and any other additional insureds, although named as an insured, will nevertheless be entitled to recover under such policies for any loss sustained by Landlord and such other
additional insureds, its agents, and employees as a result of the acts or omissions of Tenant. All such policies maintained by Tenant will provide that they may not be terminated or amended except after thirty(30) days’ prior written notice to
Landlord. All required insurance policies maintained by Tenant must be written as primary policies, not contributing with and not supplemental to the coverage that Landlord carries or may carry. 
 5.4 Waiver of Subrogation. Landlord and Tenant each waive any and all rights to recover against the other, or against the officers, directors,
shareholders, partners, joint venturers, employees, agents, customers, invitees, or business visitors of such other party, for any loss or damage to such waiving party arising from any cause covered by any property or other insurance required to be
carried by such party pursuant to this Article 5 or any other property insurance actually carried by such party. Landlord and Tenant from time to time will cause their respective insurers to issue appropriate waiver of subrogation rights
endorsements to all property insurance policies carried in connection with the Premises or the Building in which the Premises are located, or the contents thereof. Tenant agrees to cause all other occupants of the Premises claiming by, under, or
through Tenant to execute and deliver to Landlord such a waiver of claims and to obtain such waiver of subrogation rights endorsements. 

 5.5 Indemnification. Tenant shall indemnify, defend and save Landlord harmless from and against
any and all claims, actions, damages, liability and expense in connection with loss of life, personal injury and/or damage to or destruction of property arising from or out of any occurrence in, upon or at the Premises, or any part thereof, or the
occupancy or use by Tenant of the Premises or any part thereof, or occasioned wholly or in part by any act or omission of Tenant, its agents, contractors, employees, servants, lessees or concessionaires, except which result from Landlord’s
gross negligence or willful misconduct. Landlord shall indemnify, defend and save Tenant harmless from and against any and all claims, actions, damages, liability and expense in connection with loss of life, personal injury and/or damage to or
destruction of property arising from or out of any occurrence in, upon or at the Premises occasioned in whole or in part by any negligent act or omission by Landlord, its agents, contractors, employees, servants or concessionaires. In case the
indemnifying party shall be made a party to any litigation commenced by or against the other party, then such other party shall protect and hold the indemnified party harmless and pay all costs and attorney’s fees incurred by the indemnified
party in connection with such litigation, and any appeals thereof. The defaulting party shall also pay all costs, expenses and reasonable attorney’s fees that may be incurred or paid by the other party in enforcing the covenants and agreements
in this Lease. 
 ARTICLE 6 
 UTILITIES 
 6.1 Utilities. Tenant shall be solely responsible for and shall promptly pay all charges for water, gas,
electricity, garbage, and any other utility used and consumed in the Premises. In the event that such utilities charges, or any portion thereof, shall be separately metered for the Premises, Tenant shall pay such meter charges directly to the
utility company supplying such service. In the event, however, that such utilities charges, or any portion thereof, shall not be separately metered for the Premises, tenant shall pay to Landlord its pro rata share of such non-metered charges. If any
such charges are not paid when due, Landlord may, at its option pay the same, and any amount so paid by Landlord shall thereupon become due to Landlord from tenant as additional rent. In no event, however, shall Landlord be liable for an
interruption or failure in the supply of any such utilities to the Premises. 
 ARTICLE 7 
 SUBORDINATION AND ATTORNMENT 
 7.1
Subordination. Tenant hereby subordinates its rights hereunder to the lien of any ground or underlying leases, any mortgage or mortgages, or the lien resulting from any other method of financing or refinancing, now or hereafter in force
against the Premises and to all advances made or hereafter to be made upon the security thereof so long as the lessor or mortgagee or other lien holder thereunder agrees not to disturb Tenant’s possession of the Premises or rights under this
Lease so long as Tenant is not in default hereunder. This Section shall be self-operative and binding upon Tenant and any such lessor, mortgagee or other lien holder, and no further instrument of subordination shall be required by any mortgagee, but
Tenant agrees upon request of Landlord, from time to time, to promptly execute and deliver any and all documents evidencing such subordination and non-disturbance, and failure to do so shall constitute a default under this Lease. 
 7.2 Attornment. In the event any proceedings are brought for the foreclosure of, or in the event of exercise of the power of sale under, any
mortgage covering the Premises or in the event a deed is given in lieu of foreclosure of any such mortgage, Tenant shall attorn to the purchaser, or grantee in lieu of foreclosure, upon any such foreclosure or sale and recognize such purchaser, or
grantee in lieu of foreclosure, as the Landlord under this Lease. 

 7.3 Financing Agreements. Tenant shall not enter into, execute or deliver any financing agreement
that can be considered as having priority on the Premises to any mortgage or deed of trust that Landlord may have placed upon the Premises. 
 ARTICLE 8 
 ASSIGNMENT AND SUBLETTING 
 Except as herein provided, Tenant may not assign this lease in whole or in part, nor sublet all or any portion of the Premises, without the prior written consent of Landlord in each instance, which shall not be
unreasonably withheld or delayed and shall be deemed granted if not given or denied in writing within thirty (30) days from Tenant’s written request therefor. Further, notwithstanding the foregoing, such consent shall not be required if
such assignment or sublease is from Tenant to a wholly owned subsidiary of Tenant or to a wholly owned subsidiary of Tenant’s parent, if any. The consent by Landlord to any assignment or subletting shall not constitute a waiver of the necessity
for such consent to any subsequent assignment or subletting. No assignment, under letting, occupancy or collection shall be deemed acceptance of the assignee, subtenant or occupant as Tenant, or a release of Tenant from the further performance by
Tenant of the covenants on the part of Tenant herein contained. This prohibition against any assignment or subleasing by operation of law, legal process, receivership, bankruptcy or otherwise, whether voluntary or involuntary. Landlord by its
acceptance hereof acknowledges that Tenant may mortgage or collaterally assign its interest in and to this Lease and the leasehold estate created hereunder to institutional lenders providing financing to Tenant, to Tenant’s parent, if any, or
to any subsidiary or affiliate of Tenant. Tenant shall remain fully liable on this Lease and shall not be released from performing any of the terms, covenants and conditions hereof or any rents or other sums to be paid hereunder. Tenant acknowledges
and agrees that any and all right and interest of the Landlord in and to the Premises, and all right and interest of the Landlord in this Lease, may be conveyed, assigned or encumbered at the sole discretion of the Landlord at any time. 

ARTICLE 9 
 FACILITIES

 9.1 Control of Common Areas by Landlord. All automobile parking areas, driveways, entrances and exits thereto, and other
facilities furnished by Landlord at or near the Premises, including employee parking areas, the truck way or ways, loading docks, package pick-up stations, pedestrian sidewalks and ramps, landscaped areas, exterior stairways, and other areas and
improvements provided by Landlord for the general use, in common, of tenants, their officers, agents, employees and customers, shall at all times be subject to the exclusive control and management of Landlord, and Landlord shall have the right from
time to time to establish, modify and enforce reasonable rules and regulations with respect to all facilities and areas mentioned in this Article. Landlord shall have the right to construct, maintain and operate lighting facilities on all said areas
and improvements; from time to time to change the area, level, location and arrangement of parking areas and other facilities hereinabove referred to and to restrict parking by tenants, their officers, agents and employees to employee parking areas.
Landlord shall not have any duty to police the traffic in the parking areas. Tenant is to maintain and repair parking and at tenant’s expense. Landlord shall provide not less than
[            ] parking spaces within the parking area, which Landlord warrants meets all parking requirements of any governmental authority, which shall include not less than handicapped
spaces. 

 ARTICLE 10 
 TENANT’S FIXTURES AND IMPROVEMENTS 
 10.1 Alterations by Tenant. Tenant shall not make
any alterations, renovations, improvements or other installations (collectively “Alterations”) in, on or to any part of the Premises (including, without limitation, any alterations of the front, signs, structural alterations, or any
cutting or drilling into any part of the Premises or any securing of any fixture, apparatus, or equipment of any kind to any part of the Premises) unless and until Tenant shall have caused plans and specifications therefor to have been prepared, at
Tenant’s expense, by an architect or other duly qualified person and shall have obtained Landlord’s approval thereof, which shall not be unreasonably withheld or delayed and shall be deemed granted if not approved or denied in writing
within thirty (30) days of Tenant’s written request therefor. Tenant shall submit to Landlord detailed drawings and plans of the proposed Alterations at the time Landlord’s approval is sought. If such approval is granted, Tenant shall
cause the work described in such plans and specifications to be performed, at its expense, promptly, efficiently, competently and in a good and workmanlike manner by duly qualified and licensed persons or entities approved by Landlord, using first
grade materials. All such work shall comply with all applicable codes, rules, regulations and ordinances. The Tenant shall at all times maintain fire insurance with extended coverage in an amount adequate to cover the cost of replacement of all
alterations, decorations, additions or improvements to the Premises by Tenant in the event of fire or extended coverage loss. Tenant shall deliver to the Landlord certificates of such fire insurance policies, which shall contain a clause requiring
the insurer to give the Landlord ten (10) days notice of cancellation of such policies. 
 10.2 Mechanic’s/Construction
Liens. No work performed by Tenant pursuant to this Lease, whether in the nature of erection, construction, alteration or repair, shall be deemed to be for the immediate use and benefit of Landlord so that no mechanic’s or other lien shall
be allowed against the estate of Landlord by reason of any consent given by Landlord to Tenant to improve the Premises. Tenant shall place such contractual provisions as Landlord may request in all contracts and subcontracts for Tenant’s
improvements assuring Landlord that no mechanic’s/Construction liens will be asserted against Landlord’s interest in the Premises or the property of which the Premises are a part. Said contracts and subcontracts shall provide, among other
things, the following: That notwithstanding anything in said contracts or subcontracts to the contrary, Tenant’s contractors, subcontractors, suppliers and materialmen (hereinafter collectively referred to as “Contractors”) will
perform the work and/or furnish the required materials on the sole credit of Tenant; that no lien for labor or materials will be filed or claimed by the Contractors against Landlord’s interest in the Premises or the property of which the
Premises are a part; that the Contractors will immediately discharge any such lien filed by any of the Contractor’s suppliers, laborers, materialmen or subcontractors; and that the Contractors will indemnify and save Landlord harmless from any
and all costs and expenses, including reasonable attorney’s fees, suffered or incurred as a result of any such lien against Landlord’s interest that may be filed or claimed in connection with or arising out of work undertaken by the
Contractors. Tenant shall pay promptly all persons furnishing labor or materials with respect to any work performed by Tenant or its Contractors on or about the Premises. If any mechanic’s or other liens shall at any time be filed against the
Premises or the property of which the Premises are a part by reason of work, labor, services or materials performed of furnished, or alleged to have 

 
been performed or furnished, to Tenant or to anyone holding the Premises through or under Tenant, and regardless of whether any such lien is asserted against
the interest of Landlord or Tenant, Tenant shall cause the same to be discharged of record or bonded to the reasonable satisfaction of Landlord within thirty (30) days of notice of such lien. If Tenant shall fail to cause such lien to be so
discharged or bonded after being notified of the filing thereof, then, in addition to being an Event of Default and any other right or remedy of Landlord, Landlord may bond or discharge the same by paying the amount claimed to be due, and the amount
so paid by Landlord, including reasonable attorneys’ fees incurred by Landlord either in defending against such lien or in procuring the bonding or discharge of such lien, together with interest thereon at the Default Rate, shall be due and
payable by Tenant to Landlord as Additional Rent. 
 10.3 Tenant’s Leasehold Improvements and Trade Fixtures; Landlord’s Lien
Waiver. All leasehold improvements (as distinguished from trade fixtures and apparatus) installed in the Premises at any time, whether by or on behalf of Tenant or by or on behalf of Landlord, shall not be removed from the Premises at any time,
unless such removal is consented to in advance by Landlord; and at the expiration of this Lease (either on the Expiration Date or upon such earlier termination as provided in this Lease), all such leasehold improvements shall be deemed to be part of
the Premises, shall not be removed by Tenant when it vacates the Premises, and title thereto shall vest solely in Landlord without payment of any nature to Tenant. 
 All trade fixtures, equipment, furniture, inventory, and apparatus (as distinguished from leasehold improvements) owned by Tenant and installed in the Premises shall remain the property of Tenant and shall be removable at any time,
including upon the expiration of the Term; provided Tenant shall not at such time be in default of any terms or covenants of this Lease, and provided further, that Tenant shall repair any damage to the Premises caused by the removal of said trade
fixtures and apparatus and shall restore the Premises to substantially the same condition as existed prior to the installation of said trade fixtures and apparatus and shall restore the Premises to substantially the same condition as existed prior
to the installation of said trade fixtures and apparatus. Landlord acknowledges that Tenant may from time to time or at any time grant security interests in and to its trade fixtures, equipment, furniture, inventory and apparatus in order to secure
financing provided to Tenant. Landlord consents to Tenant’s granting one or more security interests in and to Tenant’s trade fixtures, equipment, furniture, inventory and apparatus and covenants and agrees that any security interest in and
to the Tenant’s trade fixtures, equipment, furniture, inventory and apparatus in favor of any lender or financier thereof shall be superior to any interest which Landlord may at any time have in and to Tenant’s trade fixtures, equipment,
furniture, inventory and apparatus and Landlord, for itself, its successors and/or assigns, does hereby subordinate any and all liens, encumbrances and/or security interests which it has or may have in and to Tenant’s trade fixtures, equipment,
furniture, inventory and apparatus, whether expressly created in this Lease or any other instrument by and between Landlord and Tenant, or by virtue of any statute or under common law. Landlord covenants and agrees with Lender that, for so long as
any lender or financier holds any lien, encumbrance of security interest in and to Tenant’s trade fixtures, equipment, furniture, inventory and apparatus, Landlord will not assert against any of Tenant’s trade fixtures, equipment,
furniture, inventory and apparatus any statutory, common law, contractual, or possessory lien or security interest, including without limitation any right of levy or destraint for rent, all of which Landlord does hereby waive and subordinate.
Landlord agrees that any such lender or financier may enter upon the Premises at any time or from time to time, during normal business hours, so long as Tenant is in possession of the Premises, without charge, to 

 
inspect or remove any of Tenant’s trade fixtures, equipment, furniture, inventory and apparatus therefrom. Landlord covenants and agrees that Landlord
will not hinder or delay any such lender’s or financier’s actions in enforcing its liens, security interests, and remedies with respect to Tenant’s trade fixtures, equipment, furniture, inventory and apparatus. 
 ARTICLE 11 
 MAINTENANCE AND REPAIR
OF PREMISES 
 11.1 Maintenance by Tenant. Tenant shall at all times keep in good order, condition and repair (which shall include
the providing of replacements where necessary) the entire Premises, including, without limitation, the roof, the exterior and all glass and show window moldings; and all partitions, doors, interior walls, fixtures, equipment and appurtenances
thereto, including lighting, heating and plumbing fixtures serving the Premises only and any air conditioning system and sprinkler system situated within and/or servicing the Premises, reasonable and ordinary wear and tear excepted. Said maintenance
by Tenant shall include, without limitation, periodic painting as is reasonably necessary. All cutting and patching of the roof area required for any reason whatsoever for Tenant’s use and occupancy of the Premises shall be performed by the
Landlord’s roofing subcontractor. In the event that Tenant causes such work to be performed by anyone other than the Landlord’s roofing subcontractor, Landlord will have the right, at Tenant’s sole cost and expense and without notice
to Tenant, to cause said work and the roof area affected thereby to be inspected and/or repaired by Landlord’s roofing subcontractor. All repairs, replacements, or maintenance of any item or any type of the Premises, other than building
structure and any capital improvements thereto, is the responsibility of the Tenant and to be paid for by Tenant. 
 11.2 Maintenance by
Landlord. Other than maintenance obligations of Tenant as provided in Section 11.1, Landlord shall be responsible for all other maintenance to the Premises, the building in which the Premises are located and all common and parking areas,
including without limitation all structural elements of the building, all capital improvements, all common plumbing facilities, and paving and striping of the parking areas. 
 ARTICLE 12 
 SIGNS 
 On or before the Commencement Date, Tenant will at its sole cost and expense purchase and cause to be installed upon the exterior of the Premises a sign
which in all respects conforms to the criteria established by Landlord. However, Tenant will not install said sign without first obtaining Landlord’s written approval thereof, which shall not be unreasonably withheld or delayed and shall be
deemed granted if written approval or rejection thereof has not been received within thirty (30) days of Tenant’s written request therefor. Thereafter, Tenant will not place or suffer to be placed or maintain on any portion of the exterior
(including windows) of the Premises any sign, awning, canopy or advertising matter or other thing of any kind, without first obtaining Landlord’s written approval and consent. Without limitation as to the foregoing, Landlord specifically
reserves the right at any time during the term of this Lease to require Tenant to remove from the Premises any sign(s) situated thereon which have not been approved pursuant to the foregoing provisions and to replace same with a sign or signs which
in all respects conform to a sign standard designated by Landlord, all of which will be performed at Tenant’s sole cost and expense. Tenant agrees to maintain any such sign, awning, canopy, 

 
decoration, lettering, advertising matter or other thing as may be approved in good condition and repair at all times, reasonable and ordinary wear and tear
excepted, and to repaint or replace such signs from time to time when reasonably necessary and to illuminate such signs in accordance with standards established by Landlord from time to time, including hours of illumination. All signs in addition
must be conform to code and local ordinances rules, laws and regulations. 
 ARTICLE 13 
 WASTE AND GOVERNMENTAL REGULATIONS 
 13.1 Nuisance or Waste. Tenant shall not commit or suffer to be committed any waste upon the Premises or any nuisance or other act or thing which may disturb the quiet enjoyment of any other tenant in the building in which the
Premises may be located. 
 13.2 Compliance with Laws. Tenant, at its sole cost, will promptly comply with all applicable laws,
guidelines, rules, regulations and requirements, whether of federal, state, or local origin, applicable to the Premises, including, but not limited to, the Americans with Disabilities Act, 42 U.S.C. § 12101 et seq., and those for the
correction, prevention and abatement of nuisance, unsafe conditions, or other grievances arising from or pertaining to the Tenant’s use or occupancy of the Premises. Tenant at its sole cost and expense shall be solely responsible for taking any
and all measures which are required to comply with the requirements of the ADA within the Premises as a result of Tenant’s use, other than as set forth below. Any Alterations to the Premises made by or on behalf of Tenant for the purpose of
complying with the ADA or which otherwise require compliance with the ADA shall be done in accordance with this Lease; provided, that Landlord’s consent to such Alterations shall not constitute either Landlord’s assumption, in whole or in
part, of Tenant’s responsibility for compliance with the ADA with respect to the Tenant’s use of the Premises, or representation or confirmation by Landlord that such Alterations comply with the provisions of the ADA. Notwithstanding the
foregoing, Landlord shall be solely responsible for all costs associated with bringing the Building within which the Premises are located into compliance with the ADA as a result of any structural condition of the Building. 
 13.3 Governmental Regulations. Tenant shall, at Tenant’s sole costs and expense, comply in all material respects with all regulations of all
county, municipal, state, federal and other applicable governmental authorities, not in force or which may hereafter be in force, pertaining to Tenant or its use of the Premises, and shall faithfully observe in the use of the Premises all municipal
and county ordinances and state and federal statutes now in force or which may hereinafter be in force. Tenant shall indemnify, defend and save Landlord harmless from penalties, fines, costs, expenses suits, claims, or damages resulting from
Tenant’s failure to perform its obligations in this Section. 
 13.4 Rules and Regulations. Landlord reserves the right from time
to time to make reasonable rules and regulations, governing loading of supplies, trash collection, pest control, parking, noise, electrical overloads and similar issues of general concern to all tenants in the event that the need therefore should
ever arise. Notice of such rules and regulations and amendments and supplements thereto, if any, shall be given to the Tenant. 

 ARTICLE 14 
 HAZARDOUS MATERIALS 
 14.1 Hazardous Materials. Tenant shall not use or allow the Premises to
be used for the Release, storage, use, treatment, disposal or other handling of any Hazardous Materials, without the prior consent of Landlord, except that Tenant may without Landlord’s prior written consent store, use, treat and handle such
Hazardous Materials as are ordinarily and commonly used in its operation of medical offices and radiation treatment facilities provided that it does so, and disposes of same, in accordance and compliance with applicable environmental laws, rules and
regulations (“Tenant’s Hazardous Materials Activity”). The term “Release” shall have the same meaning as is ascribed to it in the Comprehensive Environmental Response, Compensation and Liability Act, 42 U.S.C. § 9601 et
seq., as amended, (“CERCLA”). The term “Hazardous Materials” means (i) any substance defined as a “hazardous substance” under CERCLA, (ii) petroleum, petroleum products, natural gas, natural gas liquids,
liquefied natural gas, and synthetic gas, and (iii) any other substance or material deemed to be hazardous, dangerous, toxic, or a pollutant under any federal, state, or local law, code, ordinance or regulation (“Hazardous Materials
Laws”). 
 Tenant shall: (a) except respect to Tenant’s Hazardous Materials Activity, to give prior notice to Landlord of any
other activity or operation to be conducted by Tenant at the Premises which involves any other Release, use, handling, generation, treatment, storage, or disposal of any Hazardous Materials, (b) comply in all material respects with all federal,
state, and local laws, codes, ordinances, regulations, permits and licensing conditions governing the Release, discharge, emission, or disposal of any Hazardous Materials and prescribing methods for or other limitations on storing, handling, or
otherwise managing Hazardous Materials, (c) at its own expense, promptly contain and remediate any Release of Hazardous Materials arising from or related to Tenant’s Hazardous Materials Activity in the Premises and remediate and pay for
any resultant damage to properly, persons, and/or the environment, (d) give prompt notice to Landlord, and all appropriate regulatory, authorities, of any Release of any Hazardous Materials in the Premises arising from or related to,
Tenant’s Hazardous Materials Activity, which Release is not made pursuant to and in conformance with the terms of any permit or license duly issued by appropriate governmental authorities, any such notice to include a description of
“measures taken or proposed to be taken” by Tenant to contain and remediate the Release and any resultant damage to property, persons, or the environment, (e) at Landlord’s written request, which shall not be more frequent than
once per calendar year, retain an independent engineer or other qualified consultant or, expert acceptable to Landlord, to conduct, at Tenant’s expense, an environmental audit of the Premises and immediate surrounding areas, and the scope of
work to be performed by such engineer, consultant, or expert shall be reasonably approved in advance by Landlord, and all of the engineer’s, consultant’s or expert’s work product shall be made available to Landlord, (f) at
Landlord’s written request from time to time, executed affidavits, representations and the like concerning Tenant’s best knowledge, and belief regarding the presence of Hazardous Materials in the Premises, (g) reimburse to Landlord,
upon demand, the actual reasonable cost of any testing for the purpose of ascertaining if there has been any Release of Hazardous Materials in the Premises as a result of Tenant’s Hazardous Materials Activity, if such testing is required by any
governmental agency or Landlord’s Mortgagee, (h) upon expiration or termination of this Lease, surrender the Premises to Landlord free from the presence and contamination of any Hazardous Materials. Tenant shall indemnify, protect, defend
(by counsel reasonably acceptable to Landlord), and hold Landlord and free and harmless from and against any and all claims, liabilities, penalties, forfeitures, losses and expenses (including actual reasonable attorneys’ fees) or death of or
injury to any person or damage to any property whatsoever arising from or caused in whole or in part, directly or indirectly, by the presence in or about the Premises of any of Tenant’s Hazardous Materials Activity or by Tenant’s 

 
failure to comply with any Hazardous Materials Law regarding Tenant’s Hazardous Materials Activity or in connection with any removal, remediation, clean
up, restoration and materials required hereunder to return the Premises and any other property of whatever nature to their condition existing prior to Tenant’s Hazardous Materials Activity. 
 14.2 Disclosure Warning and Notice Obligations. Tenant shall comply with all laws, ordinances and regulations in the State/Commonwealth of Florida
regarding the disclosure of the presence or danger of Tenant’s Hazardous Materials. Tenant acknowledges and agrees that all reporting and warning obligations required under the Hazardous Materials Laws with respect to Tenant’s Hazardous
Materials Activity are the sole responsibility of Tenant, whether or not such Hazardous Materials Laws permit or require Landlord to provide such reporting or warnings, and Tenant shall be solely responsible for complying with such Hazardous
Materials Laws regarding the disclosure of, the presence or danger of Tenant’s Hazardous Materials Activity. Tenant shall immediately notify Landlord, in writing, of any complaints, notices, warnings, reports or asserted violations of which
Tenant becomes aware relating to Hazardous Materials on or about the Premises. Tenant shall also immediately notify Landlord if Tenant knows or has reason to believe Tenant’s Hazardous Materials have or will be released in or about the
Premises. 
 14.3 Environmental Tests and Audits. Except to the extent required by any governmental authority having jurisdiction over
the Premises or Tenant’s use or occupancy thereof, including without limitation Tenant’s Hazardous Materials Activity, Tenant shall not perform or cause to be performed, any Hazardous Materials surveys, studies, reports or inspection,
relating to the Premises without obtaining Landlord’s advance written consent, which consent may be withheld in Landlord’s sole discretion. At any time prior to the expiration of the Term, Landlord shall have the right to enter upon the
Premises in order to conduct appropriate tests and to deliver to Tenant the results of such tests to demonstrate that levels of any Hazardous Materials in excess of permissible levels has occurred as a result of Tenant’s Hazardous Materials
Activity. 
 14.4 Survival/Tenant’s Obligations. The respective rights and obligations of Landlord and Tenant under this Article
shall survive the expiration or termination of this Lease. 
 ARTICLE 15 
 DESTRUCTION OF PREMISES 
 15.1 Damage and Destruction. If all or any part
of the Premises shall be damaged or destroyed by fire or other casualty, this Lease shall continue in full force and effect, unless terminated as hereinafter provided, and Landlord shall repair, restore or rebuild the Premises to the condition
existing at the time of the occurrence of the loss; provided, however, Landlord shall not be obligated to commence such repair, restoration or rebuilding until insurance proceeds are received by Landlord, and Landlord’s obligation hereunder
shall be limited to the proceeds actually received by Landlord under any insurance policy or policies, if any, less those amounts (i) which have been required to be applied towards the reduction of any indebtedness secured by a mortgage
covering the Premises or any portion thereof, and (ii) which are used to reimburse Landlord for all costs and expenses, including but not limited to attorneys’ fees, incurred by Landlord to recover any such insurance proceeds. 

Tenant agrees to notify Landlord in writing not less than thirty (30) days prior, to the date Tenant opens for business in the Premises of the
actual cost of all permanent leasehold improvements and betterments installed or to be installed by Tenant in the Premises (whether 

 
same have been paid for entirely or partially by Tenant), but exclusive of Tenant’s personal property, movable trade fixtures, equipment, furniture,
apparatus and inventory. Similar notifications shall be given to Landlord not less than thirty (30) days prior to the commencement of any proposed alterations, additions or improvements to the Premises. If Tenant fails to comply, with the
foregoing provisions, any loss or damage Landlord shall sustain by reason thereof shall be borne by Tenant and shall be paid immediately by Tenant upon receipt of a bill therefore and evidence of such loss, and in addition to any other rights or
remedies reserved by Landlord under this Lease, Landlord’s obligations under this Article to repair, replace and/or rebuild the Premises shall be deemed inapplicable, and in lieu thereof, Landlord may, at its election, either restore or require
Tenant to restore the Premises to the condition which existed prior to such loss, and in either case Tenant shall pay the cost of such restoration. 
 Tenant covenants and agrees to repair or replace Tenant’s fixtures, furniture, furnishings, floor coverings, equipment and stock in trade and reopen for business in the Premises within thirty (30) days after notice from Landlord
that the Premises are ready for re-occupancy. 
 No damage or destruction to the Premises shall allow Tenant to surrender possession of the
Premises nor affect Tenant’s liability for the payment of rents or charges or any other covenant herein contained, except as may be specifically provided in this Lease. 
 Notwithstanding anything to the contrary contained in this Section or elsewhere in this Lease, either Tenant or Landlord, at their respective option, may
terminate this Lease by giving written notice thereof to the other within one hundred and eighty (180) days from the date of the casualty if: 
 (a) The Premises or the building in which the Premises are located shall be damaged or destroyed as a result of an occurrence which is not covered by Landlord’s insurance; or 
 (b) The Premises shall be damaged or destroyed during the last two (2) years of the Term or any renewals thereof; or 
 (c) The Premises are damaged or destroyed to the extent of twenty five-percent (25%) or more of the replacement cost thereof, in which event
Landlord will have the option of terminating this Lease or any renewal thereof by serving written notice upon Tenant and any prepaid Rent or Additional Rent will be prorated as of the date of destruction and the unearned portion of such Rent will be
refunded to Tenant without interest. 
 If the Premises shall be damaged or destroyed and in the event that neither party has elected to
terminate this Lease as aforesaid, Landlord and Tenant shall commence their respective obligations under this Article as soon as is reasonably possible and prosecute the same to completion with all due diligence. 
 Except where the damage or destruction results from the wrongful or grossly negligent act or omission of Tenant, the Minimum Rent shall be abated
proportionately with the degree to which Tenant’s use of the Premises is impaired during the period of any damage, repair or restoration provided for in this Article; provided further, that in the event Landlord elects to repair any damages as
herein contemplated, any abatement of Minimum Rent shall end ten (10) days after written notice by Landlord to Tenant that the Premises have been repaired. Tenant shall continue the operation of its business on the Premises during any such
period to the extent 

 
reasonably practicable from the standpoint of prudent business management, and any obligation of Tenant under the Lease to apply charges reserved as
Additional Rent shall remain in full force and nothing in the Section shall be construed to abate Additional Rent. Except for the abatement of Minimum Rent hereinabove provided, Tenant shall not be entitled to any compensation or damage for loss in
the use of the whole or any part of the Premises and/or any inconvenience or annoyance occasioned by any damage, destruction, repair or restoration. If Minimum Rent is abated there shall be all corresponding and appropriate reduction made to the
Minimum Annual Volume. 
 Unless this Lease is terminated by Landlord or Tenant within the time period provided hereinabove, Landlord shall
repair, restore and re-fixture all parts of the Premises not insured under any insurance policies insuring Landlord in a manner and to a condition equal to that existing prior to its destruction or damage, including, without limitation, all exterior
signs, trade fixtures, equipment, display cases, furniture, furnishings and other installations of personality of Tenant. The proceeds of all insurance carried by Tenant on its property and improvements shall be held in trust by Tenant for the
purpose of said repair and replacement. Tenant shall give to Landlord prompt written notice of, any damage to or destruction of any portion of the Premises resulting from fire or other casualty. 
 ARTICLE 16 
 EMINENT DOMAIN

 16.1 Total Condemnation of Premises. If the whole of the Premises shall be acquired or condemned by eminent domain for any
public or quasi-public use or purpose, then the Term of this Lease shall cease and terminate as of the date of title vesting in such proceeding and all rentals shall be paid up to that date. 
 16.2 Partial Condemnation of Premises. 
 16.2.1 If twenty (20%) percent or more of the Premises shall be acquired or condemned by eminent domain for any public or quasi-public use or purpose, then the Tenant shall have the option to cancel and terminate this Lease upon notice
thereof given to the Landlord within ninety (90) days after the vesting of title in such proceeding. 
 16.2.2 In the event that less
than twenty (20%) percent of the Premises shall be acquired or condemned by eminent domain for any public or quasi-public use or purpose, or in the event twenty (20%) percent or more of the Premises shall have been so taken, and Tenant
shall not elect to terminate this Lease as set forth above, then the Landlord shall promptly restore the Premises to a condition reasonably comparable under the circumstances to its condition at the time of such condemnation, less the portion lost
in the taking; and this Lease shall thereafter continue in full force and effect. In such event of a partial taking, described hereinabove, from the effective date that physical possession is taken by the condemning authority through the end of the
term of this Lease, the annual Minimum Rent payable by Tenant to Landlord under this Lease shall be reduced by a fraction, the numerator of which shall be the gross area of the premises so taken by the condemning authority and the denominator of
which shall be the gross area of the Premises on the date immediately prior to the effective date of such taking. 
 16.3 Total
Condemnation of Parking. If the whole of the common parking areas at or near the Premises shall be acquired or condemned by eminent domain for any public or quasi-public use or purpose, then the term of this Lease shall cease and terminate as of
the date of title vesting in such proceeding. 

 16.4 Partial Condemnation of Parking Area. If twenty (20%) percent or more of the common
parking areas at or near the Premises shall be acquired or condemned by eminent domain for any public or quasi-public use or purpose, then the Tenant shall have the option to cancel and terminate this Lease upon notice thereof given to the Landlord
within ninety (90) days after the vesting of title in such proceeding. 
 If less than twenty (20%) percent of the parking areas at
or near the Premises shall be acquired or condemned by eminent domain for any public or quasi-public use or purpose, or if more than twenty (20%) percent of the parking areas shall be so acquired or condemned, but Tenant shall not elect to
cancel and terminate this Lease, then the Landlord shall restore the parking areas to a condition reasonably comparable under the circumstances to its condition at the time of such condemnation, less the portion lost in the taking. In such event,
this Lease shall be and remain in full force and effect and no reduction of Minimum Rent or any Additional Rent payable by Tenant under this Lease shall be allowed in such circumstances, but Tenant shall continue to pay the full Minimum Rent or any
Additional Rent payable under this Lease for the balance of the term hereof. 
 ARTICLE 17 
 DEFAULTS 
 17.1 Events of Default By
Tenant. If (1) Tenant abandons or surrenders all or any part of the Premises prior to the expiration of the Term of the Lease or (2) Tenant fails to pay Rent or Additional Rent within five (5) days after notice from Landlord of
delinquency, (3) Tenant fails to fulfill any of the terms or conditions of this Lease or any other lease heretofore made by Tenant for space in the Premises and the same is not cured within thirty (30) days after written notice thereof
from Landlord, unless the same cannot be cured within said thirty (30) day period, in which case Tenant shall have such additional time as is reasonably necessary to cure such default, not to exceed ninety (90) days in any and all events,
provided that Tenant commences such cure within said thirty (30) day period and thereafter diligently prosecutes the same to completion, or (4) the appointment of a trustee or a receiver to take possession of all or substantially all of
Tenant’s assets occurs, or if the attachment, execution or other judicial seizure of all or substantially all of Tenant’s assets located at the Premises, or of Tenant’s interest in this Lease, occurs, and in the case of an involuntary
appointment only, the same is not dismissed within ninety (90) days from said appointment, or (5) Tenant or any of its successors or assigns or any guarantor of this Lease (“Guarantor”) should file any voluntary petition in
bankruptcy, reorganization or arrangement, or an assignment for the benefit of creditors or for similar relief under any present or future statute, law or regulation relating to relief of debtors, or (6) Tenant or any of its successors or
assigns or any Guarantor should be adjudicated bankrupt or have an involuntary petition in bankruptcy, reorganization or arrangement filed against it and the same not be dismissed within ninety (90) days of the date of the filing thereof, or
(7) Tenant shall permit, allow or suffer to exist any lien, judgment, writ, assessment, charge, attachment or execution upon Landlord’s or to the Premises, and/or the fixtures, improvements and furnishings located thereon, except as
otherwise permitted herein; then, Tenant shall be in default hereunder. 
 17.2 Landlord’s Default. If Tenant asserts that
Landlord has failed to meet any of its obligations under this Lease, Tenant shall provide written notice (“Notice of Default”) to Landlord specifying the alleged failure to perform, and Tenant shall send by certified mail, return 

 
receipt requested, a copy of such Notice of Default to any and all mortgage holders, provided that Tenant has been previously advised of the addresses) of
such mortgage holder(s). Landlord shall have a thirty (30) day period after receipt of the Notice of Default in which to commence curing any non-performance by Landlord, and Landlord shall have as much time thereafter to complete such cure as
is necessary so long as Landlord’s cure efforts are diligent and continuous. if Landlord has not begun the cure within thirty (30) days of receipt of the Notice of Default, or Landlord does not thereafter diligently and continuously
attempt to cure, then Landlord shall be in default under this Lease. If Landlord is in default under this Lease, then the mortgage holder(s) shall have an additional thirty (30) days, after receipt of a second written notice from Tenant, within
which to cure such default or, if such default cannot be cured within that time, then such additional time as may be necessary so long as their efforts are diligent and continuous. 
 ARTICLE 18 
 LANDLORD’S REMEDIES FOR TENANT’S DEFAULT.

 18.1 Landlord’s Options. If Tenant is in default of this Lease, Landlord may, at its option, in addition to such other
remedies as may be available under the law of the State/Commonwealth of Florida: 
 (a) Terminate this Lease and Tenant’s right of
possession; or 
 (b) Terminate Tenant’s right to possession but not the Lease and/or proceed in accordance with any and all provisions
of Section 18.2 below. 
 18.2 Landlord’s Remedies. Landlord may without further notice reenter the Premises either by force
or otherwise and dispossess Tenant by summary proceedings or otherwise, as well as the legal representatives) of Tenant and/or other occupants) of the Premises, and remove their effects and hold the Premises as if this Lease had not been made, and
Tenant hereby waives the service of notice of intention to re-enter or to institute legal proceedings to that end; and/or at Landlord’s option. 
 All Rent for the balance of the Term will, at the election of Landlord, be accelerated and the present worth of same for the balance of the Term, net of amounts actually collected by Landlord, shall become immediately
due thereupon and be paid, together with all expenses of every nature which Landlord may incur such as (by way of illustration and not limitation) those for attorneys’ fees, brokerage, advertising, and refurbishing the Premises in good order or
preparing them for re-rental. For purposes of this provision, “present worth” shall be computed by discounting such amount to present worth at a discount rate equal to one percentage point above the discount rate then in effect at the
Federal Reserve Bank nearest to the location of the Premises. 
 Landlord may re-let the Premises or any part thereof, either in the name of
Landlord or otherwise, for a term or terms which may at Landlord’s option be less than or exceed the period which would otherwise have constituted the balance of the Term, and may grant concessions or free rent or charge a higher rental than
that reserved in this Lease; and/or at Landlord’s option, Tenant or its legal representatives will also pay to Landlord as liquidated damages any deficiency between the Rent and all Additional Rent hereby reserved and/or agreed to be paid and
the net amount, if any, of the rents collected on account of the lease or leases of the Premises for each month of the period which would otherwise have constituted the balance of the Term. 

 If Landlord exercises the remedy above, and provided that Tenant has paid Landlord the accelerated Rent
as required by this Section, Landlord shall remit to Tenant on a monthly basis until the Expiration Date any amounts actually collected by Landlord as a result of are letting remaining after subtracting therefrom all reasonable costs paid by
Landlord to secure a replacement tenant including reasonable marketing/leasing costs, fees and commissions, and costs of preparing improvements and refurbishment to the Premises for the replacement tenant. In no event shall the total amount paid to
Tenant pursuant to the preceding sentence exceed the accelerated Rent paid by Tenant to Landlord. If this Lease is terminated, Landlord may re-let the Premises or any part thereof, alone or together with other premises, for such term or terms (which
may be greater or less than the period which otherwise would have constituted the balance of the Term) and on such terms and conditions (which may include concessions or free rent and alterations of the Premises) as Landlord, in its sole discretion,
may determine, but Landlord shall not be liable for nor shall Tenant’s obligations hereunder be diminished by reason of, any failure by Landlord to re-let the Premises or any failure by Landlord to collect any rent due upon such re-letting.

 18.3 Waiver of Jury Trial. To the extent permitted by law, Tenant hereby waives: (a) jury trial in any action or proceeding
regarding a monetary default by Tenant and/or Landlord’s right to possession of the Premises, and (b) in any action or proceeding by Landlord for eviction where Landlord has also filed a separate action for damages, Tenant waives the right
to interpose any counterclaim in such eviction action. Moreover, Tenant agrees that it shall not interpose or maintain any counterclaim in such damages action unless it pays and continues to pay all Rent, as and when due, into the registry of the
court in which the damages action is filed. 
 18.4 Waiver of Rights of Redemption. Tenant hereby expressly waives any and all rights
of redemption granted by or under any present or future laws in the event of Tenant being evicted or dispossessed for any cause, or in the event of Landlord obtaining possession of the Premises, by reason of the violation by Tenant of any of the
covenants or conditions of this Lease or otherwise. 
 ARTICLE 19 
 BANKRUPTCY PROVISIONS 
 19.1 Event of Bankruptcy. If this Lease is
assigned to any person or entity pursuant to the provisions of the United States Bankruptcy Code, 11 U.S.C. Section 101 et seq. (the “Bankruptcy Code”), any and all monies or other consideration payable or otherwise to be delivered in
connection with such assignment shall be paid or delivered to Landlord, shall be and remain the exclusive property of Landlord, and shall not constitute the property of Tenant or of the estate of Tenant within the meaning of the Bankruptcy Code. Any
and all monies or other considerations constituting Landlord’s property under this Section not paid or delivered to Landlord shall be held in trust for the benefit of Landlord and shall be promptly paid or delivered to Landlord. Any person or
entity to which this Lease is assigned pursuant to the provisions of the Bankruptcy Code shall be deemed without further act or deed to have assumed all of the obligations arising under this Lease on and after the date of such assignment.

 19.2 Additional Remedies. In addition to any rights or remedies hereinbefore or hereinafter conferred upon Landlord under the terms
of this Lease, the following remedies and provisions shall specifically apply in the event Tenant is in default of this Lease: 
 19.2.1 In
all events, any receiver or trustee in bankruptcy shall either expressly assume or reject this Lease within sixty (60) days following the entry of an “Order for Relief’ or within such earlier time as may be provided by applicable law.

 19.2.2 In the event of an assumption of this Lease by a debtor or by a trustee, such debtor or trustee
shall within fifteen (15) days after such assumption (i) cure any default or provide adequate assurance that defaults will be promptly cured; (ii) compensate Landlord for actual pecuniary loss or provide adequate assurance that
compensation will be made for actual monetary loss, including, but not limited to, all attorneys’ fees and costs incurred by Landlord resulting from any such proceedings; and (iii) provide adequate assurance of future performance.

 19.2.3 Where a default exists under this Lease, the trustee or debtor assuming this Lease may not require Landlord to provide services or
supplies incidental to this Lease before its assumption by such trustee or debtor, unless Landlord is compensated under the terms of this Lease for such services and supplies provided before the assumption of such Lease. 
 19.2.4 The debtor or trustee may only assign this Lease if (i) it is assumed and the assignee agrees to be bound by this Lease, (ii) adequate
assurance of future performance by the assignee is provided, whether or not there has been a default under this Lease, and (iii) the debtor or trustee has received Landlord’s prior written consent pursuant to the provisions of this Lease.
Any consideration paid by any assignee in excess of the rental reserved in this Lease shall be the sole property of, and paid to, Landlord. 
 19.2.5 Landlord shall be entitled to the fair market value for the Premises and the services provided by Landlord (but in no event less than the rental reserved in this Lease) subsequent to the commencement of a bankruptcy event.

 19.2.6 Any security deposit given by Tenant to Landlord to secure the future performance by Tenant of all or any of the terms and
conditions of this Lease shall be automatically transferred to Landlord upon the entry of an “Order of Relief.” 
 19.2.7 The
parties agree that Landlord is entitled to adequate assurance of future performance of the terms and provisions of this Lease in the event of an assignment under the provisions of the Bankruptcy Code. For purposes of any such assumption or
assignment of this Lease, the parties agree that the term “adequate assurance” shall include, without limitation, at least the following: (i) any proposed assignee must have, as demonstrated to Landlord’s satisfaction, a net
worth (as defined in accordance with generally accepted accounting principles consistently applied) in an amount sufficient to assure that the proposed assignee will have the resources to meet the financial responsibilities under this Lease,
including the payment of all Rent; the financial condition and resources of Tenant are material inducements to Landlord entering into this Lease; (ii) any proposed assignee must have engaged in the Use described in Section 1.2 for at least
five (5) years prior to any such proposed assignment, the parties hereby acknowledging that in entering into this Lease, Landlord considered extensively Tenant’s permitted use and determined that such permitted business would add
substantially to the tenant balance in the Premises, and were it not for Tenant’s agreement to operate only Tenant’s permitted business on the Premises, Landlord would not have entered into this Lease, and that Landlord’s operation of
the Premises will be materially impaired if a trustee in bankruptcy or any assignee of this Lease operates any business other than Tenant’s permitted business; (iii) any assumption of this Lease by a proposed assignee shall not adversely
affect Landlord’s relationship with any of the remaining tenants in the building in which the Premises are located, 

 
taking into consideration any and all other “use” clauses and/or “exclusivity” clauses which may then exist under their leases with
Landlord; and (iv) any proposed assignee must not be engaged in any business or activity which it will conduct on the Premises and which will subject the Premises to contamination by any Hazardous Materials. 
 ARTICLE 20 
 LIMITATIONS OF
LANDLORD’S LIABILITY 
 The term “Landlord” as used in this Lease, so far as covenants or obligations on the part of the
Landlord are concerned shall be limited to mean and include only a ground lessee if the named Landlord herein is holding the premises under a ground lease for so long as the named Landlord is the holder of such ground lease interest or the owner or
owners of the fee simple of the Premises; and in the event of transfer or transfers of either the ground leasehold interest to any other person or the transfer of title to the fee premises to any person, the Landlord herein named (and in the case of
subsequent transfers or conveyances the then grantor or assignor), shall be automatically freed and relieved from and after the date of such transfer or conveyance or assignment of all liability as respects the performance of any covenant or
obligation on the part of the Landlord contained in this Lease thereafter to be performed, it being the intention of the parties that the covenants and obligations to be observed and performed by the-Landlord shall be binding upon the Landlord only
during and in respect of its period of ownership of either a leasehold interest, or a fee interest as the case may be. Anything in this Lease to the contrary notwithstanding, Tenant agrees that Tenant shall, subject to prior rights of any mortgagee
of the Premises, look solely to the estate and property of Landlord in the Premises for the collection of any judgment (or other judicial process) requiring the payment of money by Landlord in the event of any default or breach by Landlord with
respect to any of the terms, covenants and conditions of this Lease to be observed and/or performed by Landlord, and no other assets of Landlord or any principal of Landlord shall be subject to levy, execution or other procedures for the
satisfaction of Tenant’s remedies. 

 ARTICLE 21 
 ACCESS BY LANDLORD 
 Landlord or Landlord’s agents shall have the right to enter the Premises at
all reasonable times and, except in the case of emergency, on not less than forty-eight (48) hours prior notice to Tenant, to examine the same and to show them to prospective purchasers of the building, and to make such repairs, alterations,
improvements or additions as Landlord may deem necessary or desirable, and Landlord shall be allowed to take all material into and upon said Premises that may be required therefor, without the same constituting an eviction of Tenant in whole or in
part and the Rent reserved shall in no way abate while said repairs, alterations, improvements, or additions are being made, by reason of loss or interruption of business of Tenant, or otherwise. During the six (6) month period prior to the
expiration of the term of this Lease or any renewal term, unless Tenant shall have exercised its then right to renew the term of this Lease, Landlord may exhibit the Premises to prospective tenants or purchasers, and place upon the premises the
usual notices “To Let” or “For Sale” which notices Tenant shall permit to remain thereon without molestation. Nothing herein contained, however, shall be deemed or construed to impose upon Landlord any obligation, responsibility
or liability whatsoever, for the care, maintenance, or repair of the Premises or any part thereof, except as otherwise herein specifically provided. Landlord to give Tenant reasonable notice during business hours prior to any entry. 
 ARTICLE 22 
 QUIET ENJOYMENT 

 22.1 Landlord’s Covenant. Upon payment by the Tenant of the rents and other charges herein provided, and upon the observance
and performance of all the covenants, terms and conditions on Tenant’s part to be observed and performed, Tenant shall peaceably and quietly hold and enjoy the Premises for the term hereby demised without hindrance or interruption by Landlord
or any other person or persons lawfully or equitably claiming by, through or under the Landlord, subject, nevertheless, to the terms and conditions of this Lease. 
 ARTICLE 23 
 MISCELLANEOUS 
 23.1 Accord and Satisfaction. No payment by Tenant or receipt by Landlord of a lesser amount than the rent herein stipulated to be paid shall be
deemed to be other than on account of the earliest stipulated rent, nor shall any endorsement or statement on any check or any letter accompanying any check or payment as rent be deemed an accord and satisfaction, and Landlord may accept such check
or payment without prejudice to Landlord’s right to recover the balance of such rent or pursue any other remedy provided herein or by law. 
 23.2 Entire Agreement. This Lease constitutes all covenants, promises, agreements, conditions and understandings between Landlord and Tenant concerning the Premises and the Building and there are no covenants, promises, conditions or
understandings, either oral or written, between them other than are herein set forth. Neither Landlord nor Landlord’s agents have made nor shall be bound to any representations with respect to the Premises or the Building except as herein
expressly set forth, and all representations, either oral or written, shall be deemed to be merged into this Lease Agreement. Except as herein otherwise provided, no subsequent alteration change or addition to this lease shall be binding upon
Landlord or Tenant unless reduced to writing and signed by them. 

 23.3 Notices. 
 23.3.1 Any notice by Tenant to Landlord must be served by certified mail return requested, addressed to Landlord at the address first hereinabove given or at such other address as Landlord may designate by written
notice. Tenant shall also provide copies of any notice given to Landlord to such mortgagees, agents or attorneys of Landlord as Landlord may direct. 
 23.3.2 After commencement of the term hereof any notice by Landlord to Tenant shall be served by certified mail, return receipt requested addressed to Tenant at the Premises or at such other address as Tenant shall
designate by written notice, or by delivery by Landlord to the Premises or to such other address. 
  

			
	Landlord:	  	Tenant:
	2234 Colonial Blvd.	  	2234 Colonial Blvd.
	Fort Myers, FL 33907	  	Fort Myers, FL 33907
	Attn: Cathy Newkirk	  	Attn: David Watson

 23.3.3 All notices given hereunder shall be in writing, and shall be effective and deemed to have
been given only upon receipt by the party to which notice is being given, said receipt being deemed to have occurred upon hand delivery or posting, or upon such date as the postal authorities shall show the notice to have been delivered, refused, or
undeliverable, as evidenced by the return receipt. Notwithstanding any other provision hereof, Landlord shall also have the right to give notice to Tenant in any other manner provided by law. 
 23.4 Successors. All rights and liabilities herein given to, or imposed upon„ the respective parties hereto shall extend to and bind the
several respective heirs, legal representatives, and permitted successors and assigns of the said parties; and if there shall be more than one person or party constituting the Tenant, they shall be bound jointly and severally by the terms, covenants
and agreements herein. No rights, however, shall inure to the benefit of any assignee of Tenant unless the assignment to such has been approved by Landlord in writing as provided herein. Nothing contained in this Lease shall in any manner restrict
Landlord’s right to assign or encumber this Lease and, in the event Landlord sells its interest in the Building and the purchaser assumes Landlord’s obligations and covenant, Landlord shall thereupon be relieved of all further obligations
hereunder. 
 23.5 Captions and Section Numbers. The captions, section numbers, and article numbers appearing in this Lease are
inserted only as a matter of convenience and in no way define, limit, construe, or describe the scope or intent of such sections or articles of this Lease nor in any way affect this Lease. 
 23.6 Broker’s Commission. The Tenant represents and warrants to Landlord that it has dealt with no real estate broker, agent, salesperson or
finder in connection with this Lease or the Premises. Notwithstanding the foregoing, Tenant agrees to indemnify, defend and save the Landlord harmless from all liabilities arising from claims by any real estate broker or agent claiming through
Tenant. Such indemnity of Tenant shall include, without limitation, all of attorneys, fees incurred in connection therewith. 
 23.7
Partial Invalidity. If any term, covenant or condition of this Lease or the application thereof to any person or circumstances shall, to any extent, be invalid or unenforceable, the remainder of this Lease the application of such term,
covenant or condition to 

 
persons or circumstances other than those as to which it is held invalid or unenforceable, shall not be affected thereby and each term, covenant or condition
of this Lease shall be valid and enforceable to the fullest extent permitted by law. 
 23.8 Estoppel Certificate. Landlord and Tenant
agree that each will, at any time and from time to time, within ten (10) days following written notice by the other party hereto specifying that it is given pursuant to this Section, execute, acknowledge and deliver to the party who gave such
notice, or its designate, a statement in writing certifying that this Lease is unmodified and in full force and effect (or if there have been modifications, that the same is in full force and effect and stating the modifications), and
the date to which the annual rent and any other payments due hereunder from Tenant have been paid in advance, if any, and stating whether or not there are defenses or offsets claimed by the maker of the certificate and whether or not to the best of
knowledge of the signer of such certificate the other party is in default in performance of any covenant agreement or condition contained in this Lease, and if so, Specifying each such default of which the maker may have knowledge and if requested,
such financial information concerning Tenant and Tenant’s business operations (and the Guarantor of this Lease, if this Lease be guaranteed) as may be reasonably requested by any Mortgagee or prospective mortgagee or purchaser. The failure of
either party to execute, acknowledge and deliver to the other a statement in accordance with the provisions of this Section within said ten (10) business day period shall constitute an acknowledgment, by the party given such notice, which may
be relied on by any person holding or proposing to acquire an interest in the Building or any party thereof or the Premises or this Lease from or through the other party, that this Lease is unmodified and in full force and effect and that
such rents have been duly and fully paid to an including the respective due dates immediately preceding the date of such notice and shall constitute, as to any person entitled as aforesaid to rely upon such statements, waiver of any defaults
which may exist prior to the date of such notice; provided, however that nothing contained in the provision of this Section shall constitute waiver by Landlord of any default in payment of rent or other charges existing as of the date of such notice
and, unless expressly consented to in writing by Landlord, and Tenant shall still remain liable for the same. 
 23.9 Liability of
Landlord. Tenant shall look solely to the estate and property of the Landlord in the Premises for the collection of any judgment, or in connection with any other judicial process, requiring the payment of money by Landlord in the event of any
default by Landlord with respect to any of the terms, covenants and conditions of this Lease to be observed and performed by Landlord, and no other property or estates of Landlord shall be subject to levy, execution or other enforcement procedures
for the satisfaction of Tenant’s remedies and rights under this Lease. Both parties waive a jury trial if any litigation arises. 
 23.10 Recordings. Tenant shall not record this Lease, or any memorandum or short form thereof, without the written consent and joinder of Landlord. 
 23.11 Time of Essence. Time is of the essence with respect to the performance of every provision of this Lease in which time of performance is a factor. 

 ARTICLE 24 
 TENANT’S PROPERTY 
 24.1 Taxes on Leasehold. Tenant shall be responsible for and shall
pay before delinquency all municipal, county or state taxes assessed during the term of this Lease against any leasehold interest or personal property of any kind, owned by or placed in, upon or about the Premises by the Tenant. 
 24.2 Personal Property. Landlord shall not be liable for any damage to property of Tenant or of others located on the Premises, nor for the loss
of or damage to any property of Tenant or of others by theft or otherwise. Landlord shall not be liable for any injury or damage to persons or property resulting from fire, explosion, falling plaster, steam, gas, electricity, water, rain, or snow or
leaks from any part of the Premises or from the pipes, appliances or plumbing works or from the roof, street or subsurface or from any other place or by dampness or by any other cause of whatsoever nature. Landlord shall not be liable for any such
damage caused by other tenants or persons in the Premises, occupants of adjacent property, or caused by operation in construction of any private, public or quasi-public work. All property of Tenant kept or stored on the Premises shall be so kept or
stored at the sole risk of Tenant only. 
 24.3 Notice by Tenant. Tenant shall give immediate notice to Landlord in case of fire or
accidents in the Premises or in the building of which the Premises are a part or of defects therein or in any fixtures or equipment. 
 ARTICLE 25 
 HOLDING OVER SUCCESSORS 
 25.1 Surrender of Premises. At the expiration of the tenancy hereby created, Tenant shall surrender the Premises in the same condition as the Premises were in upon the Commencement Date, reasonable wear and
tear excepted, and damage by unavoidable casualty excepted, and shall surrender all keys for the Premises to Landlord at the place then fixed for the payment of rent and shall inform Landlord of all combinations on locks, safes and vaults, if any,
in the Premises. Tenant shall remove all its trade fixtures before surrendering the premises as aforesaid and shall repair any damage to the Premises caused thereby. Tenant’s obligation to observe or perform this covenant shall survive the
expiration or other termination of the term of this Lease. 
 ARTICLE 26 
 ATTORNEY FEES AND COSTS 
 26.1 Attorney Fees and Costs. In the event of a
lawsuit or litigation concerning this Lease or enforcement of this Lease the prevailing party shall be entitled to reasonable attorney fees and costs. This will also cover appellant fees and appellant costs. 
 ARTICLE 27 
 GOVERNING LAW

 27.1 Governing Law. In the event of a lawsuit, litigation or interpretation of this Lease Agreement parties shall be governed
by the laws of the State/Commonwealth of Florida. 

 ARTICLE 28 
 SPECIAL JURISDICTIONAL PROVISIONS 
 [Florida:        28.1 Radon
Gas. The following disclosure is required by Florida law: “Radon Gas: Radon is a naturally occurring radioactive gas that, when it has accumulated in a building in sufficient quantities, may present health risks to persons who are exposed
to it over time. Levels of radon that exceed federal and state guidelines have been found in buildings in Florida. Additional information regarding radon and radon testing may be obtained from your county public health unit.”] 
 IN WITNESS WHEREOF, the undersigned has hereunto set his hand and seal on 6th day of November, 2007. 
  

			
	LANDLORD:	 	 /s/ Daniel Dosoretz

		 	Daniel Dosoretz
		
	TENANT:	 	 /s/ David Watson

		 	David WatsonAmended and Restated Investors Rights Agreement

 Exhibit 4.2 
 CHEMOCENTRYX, INC. 
 AMENDED AND RESTATED 
 INVESTORS RIGHTS AGREEMENT 
 AUGUST
22, 2006 

 TABLE OF CONTENTS 
  

							
	 	 	 	  	 	  	Page
	 1. REGISTRATION RIGHTS
	  	1
				
		 	1.1	  	DEFINITIONS	  	1
		 	1.2	  	REQUEST FOR REGISTRATION	  	2
		 	1.3	  	COMPANY REGISTRATION	  	4
		 	1.4	  	FORM S-3 REGISTRATION	  	4
		 	1.5	  	OBLIGATIONS OF THE COMPANY	  	5
		 	1.6	  	FURNISH INFORMATION	  	7
		 	1.7	  	EXPENSES OF REGISTRATION	  	7
		 	1.8	  	UNDERWRITING REQUIREMENTS	  	7
		 	1.9	  	DELAY OF REGISTRATION	  	8
		 	1.10	  	INDEMNIFICATION	  	8
		 	1.11	  	REPORTS UNDER SECURITIES EXCHANGE ACT OF 1934	  	10
		 	1.12	  	ASSIGNMENT OF REGISTRATION RIGHTS	  	11
		 	1.13	  	LIMITATIONS ON SUBSEQUENT REGISTRATION RIGHTS	  	11
		 	1.14	  	MARKET-STANDOFF AGREEMENT	  	11
		 	1.15	  	TERMINATION OF REGISTRATION RIGHTS	  	12
		
	 2. COVENANTS OF THE COMPANY
	  	12
				
		 	2.1	  	DELIVERY OF FINANCIAL STATEMENTS	  	12
		 	2.2	  	INSPECTION	  	13
		 	2.3	  	RIGHT OF FIRST OFFER	  	13
		 	2.4	  	BOARD OF DIRECTORS	  	14
		 	2.5	  	OBSERVATION RIGHTS	  	14
		 	2.6	  	TERMINATION OF COVENANTS	  	15
		
	 3. MISCELLANEOUS
	  	15
				
		 	3.1	  	SUCCESSORS AND ASSIGNS	  	15
		 	3.2	  	AMENDMENTS AND WAIVERS	  	15
		 	3.3	  	NOTICES	  	16
		 	3.4	  	SEVERABILITY	  	16
		 	3.5	  	GOVERNING LAW	  	16
		 	3.6	  	COUNTERPARTS	  	16
		 	3.7	  	TITLES AND SUBTITLES	  	17
		 	3.8	  	AGGREGATION OF STOCK	  	17
		 	3.9	  	AMENDMENT AND TERMINATION OF PRIOR AGREEMENT	  	17

  

 -i- 

 AMENDED AND RESTATED INVESTORS RIGHTS AGREEMENT 
 This Amended and Restated Investors Rights Agreement (the “Agreement”) is made as of the 22 day of August, 2006, by and among
ChemoCentryx, Inc., a Delaware corporation (the “Company”), the individuals or entities who are signatories hereto, each of which is herein referred to as an “Investor,” and Thomas J. Schall (the
“Founder”). 
 This Agreement supersedes and replaces that certain Amended and Restated Investors Rights Agreement,
dated June 13, 2006, by and among the Company and the other parties named therein (the “Prior Agreement”). 
 RECITALS 
 WHEREAS, certain of the Investors are purchasing shares of the Company’s Series D Preferred Stock
pursuant to that certain Series D Preferred Stock Subscription Agreement of even date herewith (the “Subscription Agreement”); and 
 WHEREAS, the obligations in the Subscription Agreement are conditioned upon the execution and delivery of this Agreement, and the parties to the Prior Agreement desire to amend and restate the Prior Agreement in its
entirety. 
 AGREEMENT 
 The parties hereby agree as follows: 
 1. Registration Rights. The Company, the Investors and the Founder covenant and
agree as follows: 
 1.1 Definitions. For purposes of this Section 1: 
 (a) The terms “register,” “registered,” and “registration” refer to a registration effected by preparing and filing a
registration statement or similar document in compliance with the Securities Act of 1933, as amended (the “Securities Act”), and the declaration or ordering of effectiveness of such registration statement or document;

 (b) The term “Registrable Securities” means (i) the shares of Common Stock issuable or issued upon
conversion of the Series A Preferred Stock, (ii) the shares of Common Stock issuable or issued upon conversion of the Series B Preferred Stock, (iii) the shares of Common Stock issuable or issued upon conversion of the Series C Preferred
Stock, (iv) the shares of Common Stock issuable or issued upon conversion of the Series D Preferred Stock; (v) the shares of Common Stock issued to the Founder (the “Founder’s Stock”); provided, however, that
for the purposes of Section 1.2, 1.4 or 1.13 the Founder’s Stock shall not be deemed Registrable Securities and the Founder shall not be deemed a Holder, and (vi) any other shares of Common Stock of the Company issued as (or issuable
upon the conversion or exercise of any warrant, right or other security which is issued as) a dividend or other distribution with respect to, or in exchange for or in replacement of, the shares listed in (i), (ii), (iii), (iv) and (v);
provided, however, that the foregoing definition shall exclude in all cases any 

 
Registrable Securities sold by a person in a transaction in which his or her rights under this Agreement are not assigned. Notwithstanding the foregoing,
Common Stock or other securities shall only be treated as Registrable Securities if and so long as they have not been (A) sold to or through a broker or dealer or underwriter in a public distribution or a public securities transaction, or
(B) sold in a transaction exempt from the registration and prospectus delivery requirements of the Securities Act under Section 4(1) thereof so that all transfer restrictions, and restrictive legends with respect thereto, if any, are
removed upon the consummation of such sale; 
 (c) The number of shares of “Registrable Securities then outstanding” shall be
determined by the number of shares of Common Stock outstanding which are, and the number of shares of Common Stock issuable pursuant to then exercisable or convertible securities which are, Registrable Securities; 
 (d) The term “Holder” means any person owning or having the right to acquire Registrable Securities or any assignee thereof in
accordance with Section 1.12 of this Agreement; 
 (e) The term “Form S-3” means such form under the Securities
Act as in effect on the date hereof or any successor form under the Securities Act; 
 (f) The term “SEC” means the
Securities and Exchange Commission; and 
 (g) The term “Qualified IPO” means a firm commitment underwritten public
offering by the Company of shares of its Common Stock pursuant to a registration statement on Form S-1 under the Securities Act that is either (i) at a public offering price of not less than $6.00 per share (appropriately adjusted for any stock
split, dividend, combination or other recapitalization) and which results in aggregate cash proceeds to the Company of $40,000,000 (net of underwriting discounts and commissions), or (ii) upon terms approved by a majority of the outstanding
shares of the Company’s Preferred Stock. 
 1.2 Request for Registration. 
 (a) If the Company shall receive at any time after the earlier of (i) November 15, 2008, or (ii) six (6) months after the effective
date of the first registration statement for a public offering of securities of the Company (other than a registration statement relating either to the sale of securities to employees of the Company pursuant to a stock option, stock purchase or
similar plan or an SEC Rule 145 transaction), a written request from either (w) the Holders of a majority of the Series A Preferred Stock (or the Common Stock issuable or issued upon conversion thereof) then outstanding or (x) the Holders
of a majority of the Series B Preferred Stock (or the Common Stock issuable or issued upon conversion thereof) then outstanding, (y) the Holders of a majority of the Series C Preferred Stock (or the Common Stock issuable or issued upon
conversion thereof) then outstanding, or (z) the Holders of a majority of the Series D Preferred Stock (or the Common Stock issuable or issued upon conversion thereof) then outstanding, that the Company file a registration statement under the
Securities Act covering the registration of at least thirty percent (30%) of the Registrable Securities then outstanding (or a lesser percent if the anticipated aggregate offering price, net of underwriting 

  

 2 

 
discounts and commissions, would exceed $10,000,000), then the Company shall, within ten (10) days of the receipt thereof, give written notice of such
request to all Holders and shall, subject to the limitations of subsection 1.2(b), use its best efforts to effect as soon as practicable, and in any event within 60 days of the receipt of such request, the registration under the Securities Act of
all Registrable Securities which the Holders request to be registered within twenty (20) days of the mailing of such notice by the Company in accordance with Section 3.3. 
 (b) If the Holders initiating the registration request hereunder (“Initiating Holders”) intend to distribute the Registrable
Securities covered by their request by means of an underwriting, they shall so advise the Company as a part of their request made pursuant to this Section 1.2 and the Company shall include such information in the written notice referred to in
subsection 1.2(a). The underwriter will be selected by a majority in interest of the Initiating Holders and shall be reasonably acceptable to the Company. In such event, the right of any Holder to include his Registrable Securities in such
registration shall be conditioned upon such Holder’s participation in such underwriting and the inclusion of such Holder’s Registrable Securities in the underwriting (unless otherwise mutually agreed by a majority in interest of the
Initiating Holders and such Holder) to the extent provided herein. All Holders proposing to distribute their securities through such underwriting shall (together with the Company as provided in subsection 1.5(e)) enter into an underwriting agreement
in customary form with the underwriter or underwriters selected for such underwriting. Notwithstanding any other provision of this Section 1.2, if the underwriter advises the Initiating Holders in writing that marketing factors require a
limitation of the number of shares to be underwritten, then the Initiating Holders shall so advise all Holders of Registrable Securities which would otherwise be underwritten pursuant hereto, and the number of shares of Registrable Securities that
may be included in the underwriting shall be allocated among all Holders thereof, in proportion (as nearly as practicable) to the amount of Registrable Securities of the Company owned by each Holder; provided, however, that in no event shall
(i) any securities held by a Holder (other than an Initiating Holder) be included in such underwriting if any Initiating Holder’s securities are excluded from the underwriting, or (ii) the number of shares of Registrable Securities to
be included in such underwriting be reduced unless all other securities are first entirely excluded from the underwriting. 
 (c)
Notwithstanding the foregoing, if the Company shall furnish to Holders requesting a registration statement pursuant to this Section 1.2, a certificate signed by the President of the Company stating that in the good faith judgment of the Board
of Directors of the Company, it would be seriously detrimental to the Company and its stockholders for such registration statement to be filed and it is therefore essential to defer the filing of such registration statement, the Company shall have
the right to defer such filing for a period of not more than 120 days after receipt of the request of the Initiating Holders; provided, however, that the Company may not utilize this right more than once in any twelve-month period. 
 (d) In addition, the Company shall not be obligated to effect, or to take any action to effect, any registration pursuant to this Section 1.2:

 (i) With respect to Holders of the Series A Preferred Stock (or the Common Stock issuable or issued upon conversion thereof), after the
Company has effected one (1) registration pursuant to this Section 1.2 at the request of such Holders of Series A Preferred Stock and such registration has been declared or ordered effective; 
  

 3 

 (ii) With respect to Holders of the Series B Preferred Stock (or the Common Stock issuable or issued
upon conversion thereof), after the Company has effected one (1) registration pursuant to this Section 1.2 at the request of such Holders of Series B Preferred Stock and such registration has been declared or ordered effective; 

(iii) With respect to Holders of the Series C Preferred Stock (or the Common Stock issuable or issued upon conversion thereof), after the Company has
effected one (1) registration pursuant to this Section 1.2 at the request of such Holders of Series C Preferred Stock and such registration has been declared or ordered effective; 
 (iv) With respect to Holders of the Series D Preferred Stock (or the Common Stock issuable or issued upon conversion thereof), after the Company has
effected one (1) registration pursuant to this Section 1.2 at the request of such Holders of Series D Preferred Stock and such registration has been declared or ordered effective; 
 (v) During the period starting with the date sixty (60) days prior to the Company’s good faith estimate of the date of filing of, and ending
on a date one hundred eighty (180) days after the effective date of, a registration subject to Section 1.3 hereof; provided that the Company is actively employing in good faith all reasonable efforts to cause such registration statement to
become effective; or 
 (vi) If the Initiating Holders propose to dispose of shares of Registrable Securities that may be immediately
registered on Form S-3 pursuant to a request made pursuant to Section 1.4 below. 
 1.3 Company Registration. If (but
without any obligation to do so) the Company proposes to register (including for this purpose a registration effected by the Company for stockholders other than the Holders) any of its stock under the Securities Act in connection with the public
offering of such securities solely for cash (other than a registration relating solely to the sale of securities to participants in a Company stock plan or a transaction covered by Rule 145 under the Securities Act, a registration in which the only
stock being registered is Common Stock issuable upon conversion of debt securities which are also being registered, or any registration on any form which does not include substantially the same information as would be required to be included in a
registration statement covering the sale of the Registrable Securities), the Company shall, at such time, promptly give each Holder written notice of such registration. Upon the written request of each Holder given within twenty (20) days after
mailing of such notice by the Company in accordance with Section 3.3, the Company shall, subject to the provisions of Section 1.8, cause to be registered under the Securities Act all of the Registrable Securities that each such Holder has
requested to be registered. 
 1.4 Form S-3 Registration. In case the Company shall receive from any Holder or Holders
of the Registrable Securities, a written request or requests that the Company file a registration on Form S-3 and the reasonably anticipated aggregate offering price, net of underwriting discounts and commissions, would exceed $2,000,000, the
Company will: 
 (a) promptly give written notice of the proposed registration, and any related qualification or compliance, to all other
Holders; and 
  

 4 

 (b) as soon as practicable, effect such registration and all such qualifications and compliances as may
be so requested and as would permit or facilitate the sale and distribution of all or such portion of such Holder’s or Holders’ Registrable Securities as are specified in such request, together with all or such portion of the Registrable
Securities of any other Holder or Holders joining in such request as are specified in a written request given within 15 days after receipt of such written notice from the Company; provided, however, that the Company shall not be obligated to effect
any such registration, qualification or compliance, pursuant to this Section 1.4: (i) if Form S-3 is not available for such offering by the Holders; (ii) if the Company shall furnish to the Holders a certificate signed by the
President of the Company stating that in the good faith judgment of the Board of Directors of the Company, it would be seriously detrimental to the Company and its stockholders for such Form S-3 Registration to be effected at such time, in which
event the Company shall have the right to defer the filing of the Form S-3 registration statement for a period of not more than 120 days after receipt of the request of the Holder or Holders under this Section 1.4; provided, however, that the
Company shall not utilize this right more than once in any twelve month period; (iii) if the Company has, within the twelve (12) month period preceding the date of such request, already effected a registration on Form S-3 for the Holders
pursuant to this Section 1.4; (iv) in any particular jurisdiction in which the Company would be required to qualify to do business or to execute a general consent to service of process in effecting such registration, qualification or
compliance; or (v) during the period ending one hundred eighty (180) days after the effective date of a registration statement subject to Section 1.3. 
 (c) Subject to the foregoing, the Company shall file a registration statement covering the Registrable Securities and other securities so requested to be registered as soon as practicable after receipt of the request
or requests of the Holders. Registrations effected pursuant to this Section 1.4 shall not be counted as demands for registration or registrations effected pursuant to Sections 1.2 or 1.3, respectively. 
 1.5 Obligations of the Company. Whenever required under this Section 1 to effect the registration of any Registrable Securities, the
Company shall, as expeditiously as reasonably possible: 
 (a) Prepare and file with the SEC a registration statement with respect to such
Registrable Securities and use its best efforts to cause such registration statement to become effective, and, upon the request of the Holders of a majority of the Registrable Securities registered thereunder, keep such registration statement
effective for up to one hundred twenty (120) days. 
 (b) Prepare and file with the SEC such amendments and supplements to such
registration statement and the prospectus used in connection with such registration statement as may be necessary to comply with the provisions of the Securities Act with respect to the disposition of all securities covered by such registration
statement for up to one hundred twenty (120) days. 
  

 5 

 (c) Furnish to the Holders such numbers of copies of a prospectus, including a preliminary prospectus,
in conformity with the requirements of the Securities Act, and such other documents as they may reasonably request in order to facilitate the disposition of Registrable Securities owned by them. 
 (d) Use its best efforts to register and qualify the securities covered by such registration statement under such other securities or Blue Sky laws of
such jurisdictions as shall be reasonably requested by the Holders, provided that the Company shall not be required in connection therewith or as a condition thereto to qualify to do business or to file a general consent to service of process in any
such states or jurisdictions. 
 (e) In the event of any underwritten public offering, enter into and perform its obligations under an
underwriting agreement, in usual and customary form, with the managing underwriter of such offering. Each Holder participating in such underwriting shall also enter into and perform its obligations under such an agreement. 
 (f) Notify each Holder of Registrable Securities covered by such registration statement at any time when a prospectus relating thereto is required to be
delivered under the Securities Act of the happening of any event as a result of which the prospectus included in such registration statement, as then in effect, includes an untrue statement of a material fact or omits to state a material fact
required to be stated therein or necessary to make the statements therein not misleading in the light of the circumstances then existing, such obligation to continue for one hundred twenty (120) days. 
 (g) Cause all such Registrable Securities registered pursuant hereunder to be listed on each securities exchange on which similar securities issued by
the Company are then listed. 
 (h) Provide a transfer agent and registrar for all Registrable Securities registered pursuant hereunder and
a CUSIP number for all such Registrable Securities, in each case not later than the effective date of such registration. 
 (i) Use its best
efforts to furnish, at the request of any Holder requesting registration of Registrable Securities pursuant to this Section 1, on the date that such Registrable Securities are delivered to the underwriters for sale in connection with a
registration pursuant to this Section 1, if such securities are being sold through underwriters, or, if such securities are not being sold through underwriters, on the date that the registration statement with respect to such securities becomes
effective, (i) an opinion, dated such date, of the counsel representing the Company for the purposes of such registration, in form and substance as is customarily given to underwriters in an underwritten public offering, addressed to the
underwriters, if any, and to the Holders requesting registration of Registrable Securities and (ii) a letter dated such date, from the independent certified public accountants of the Company, in form and substance as is customarily given by
independent certified public accountants to underwriters in an underwritten public offering, addressed to the underwriters, if any, and to the Holders requesting registration of Registrable Securities. 
  

 6 

 1.6 Furnish Information. It shall be a condition precedent to the obligations of the
Company to take any action pursuant to this Section 1 with respect to the Registrable Securities of any selling Holder that such Holder shall furnish to the Company such information regarding itself, the Registrable Securities held by it, and
the intended method of disposition of such securities as shall be required to effect the registration of such Holder’s Registrable Securities. The Company shall have no obligation with respect to any registration requested pursuant to
Section 1.2 or Section 1.4 of this Agreement if, as a result of the application of the preceding sentence, the number of shares or the anticipated aggregate offering price of the Registrable Securities to be included in the registration
does not equal or exceed the number of shares or the anticipated aggregate offering price required to originally trigger the Company’s obligation to initiate such registration as specified in subsection 1.2(a) or subsection 1.4(b)(2), whichever
is applicable. 
 1.7 Expenses of Registration. All expenses (other than underwriting discounts and commissions incurred in
connection with registrations), filings or qualifications pursuant to Sections 1.2, 1.3 and 1.4, including (without limitation) all registration, filing and qualification fees, printers’ and accounting fees, fees and disbursements of counsel
for the Company, and the reasonable fees and disbursements of one counsel for the selling Holders selected by them with the approval of the Company, which approval shall not be unreasonably withheld, shall be borne by the Company; provided, however,
that the Company shall not be required to pay for any expenses of any registration proceeding begun pursuant to Section 1.2 if the registration request is subsequently withdrawn at the request of the Holders of a majority of the Registrable
Securities to be registered (in which case all participating Holders shall bear such expenses), unless the Initiating Holders of a majority of the Registrable Securities agree to forfeit their right to one demand registration pursuant to
Section 1.2. 
 1.8 Underwriting Requirements. In connection with any offering involving an underwriting of shares of the
Company’s capital stock, the Company shall not be required under Section 1.3 to include any of the Holders’ securities in such underwriting unless they accept the terms of the underwriting as agreed upon between the Company and the
underwriters selected by it (or by other persons entitled to select the underwriters), and then only in such quantity as the underwriters determine in their sole discretion will not jeopardize the success of the offering by the Company. If the total
amount of securities, including Registrable Securities, requested by stockholders to be included in such offering exceeds the amount of securities sold other than by the Company that the underwriters determine in their sole discretion is compatible
with the success of the offering, then the Company shall be required to include in the offering only that number of such securities, including Registrable Securities, which the underwriters determine in their sole discretion will not jeopardize the
success of the offering (the securities so included to be apportioned pro rata among the selling stockholders according to the total amount of securities entitled to be included therein owned by each selling stockholder or in such other proportions
as shall mutually be agreed to by such selling stockholders) but in no event shall (i) the amount of securities of the selling Holders included in the offering be reduced below twenty percent (20%) of the total amount of securities
included in such offering unless such offering is the initial public offering of the Company’s securities, in which case the selling Holders may be excluded if the underwriters make the determination described above and no other
stockholder’s securities are included or (ii) any securities held by a Founder be included if any securities held by any selling Holder are excluded. For purposes of the preceding 

  

 7 

 
parenthetical concerning apportionment, for any selling stockholder which is a holder of Registrable Securities and which is a partnership or corporation,
the partners, retired partners and stockholders of such holder, or the estates and family members of any such partners and retired partners and any trusts for the benefit of any of the foregoing persons shall be deemed to be a single “selling
stockholder,” and any pro-rata reduction with respect to such “selling stockholder” shall be based upon the aggregate amount of shares carrying registration rights owned by all entities and individuals included in such “selling
stockholder,” as defined in this sentence. 
 1.9 Delay of Registration. No Holder shall have any right to obtain or seek
an injunction restraining or otherwise delaying any such registration as the result of any controversy that might arise with respect to the interpretation or implementation of this Section 1. 
 1.10 Indemnification. In the event any Registrable Securities are included in a registration statement under this Section 1:

 (a) To the extent permitted by law, the Company will indemnify and hold harmless each Holder, its officers, directors, employees,
partners, members and agents, any underwriter (as defined in the Securities Act) for such Holder and each person, if any, who controls such Holder or underwriter within the meaning of the Securities Act or the Securities Exchange Act of 1934, as
amended (the “Exchange Act”), against any losses, claims, damages, or liabilities (joint or several) and reasonable expenses to which they may become subject under the Securities Act, the Exchange Act or other federal or
state law, insofar as such losses, claims, damages, or liabilities (or actions in respect thereof) arise out of or are based upon any of the following statements, omissions or violations (collectively a “Violation”):
(i) any untrue statement or alleged untrue statement of a material fact contained in such registration statement, including any preliminary prospectus or final prospectus contained therein or any amendments or supplements thereto, (ii) the
omission or alleged omission to state therein a material fact required to be stated therein, or necessary to make the statements therein not misleading, or (iii) any violation or alleged violation by the Company of the Securities Act, the
Exchange Act, any state securities law or any rule or regulation promulgated under the Securities Act, the Exchange Act or any state securities law; and the Company will pay to each such Holder, underwriter or controlling person, as incurred, any
legal or other expenses reasonably incurred by them in connection with investigating or defending any such loss, claim, damage, liability, or action; provided, however, that the indemnity agreement contained in this subsection 1.10(a) shall not
apply to amounts paid in settlement of any such loss, claim, damage, liability, or action if such settlement is effected without the consent of the Company (which consent shall not be unreasonably withheld), nor shall the Company be liable to any
Holder, underwriter or controlling person for any such loss, claim, damage, liability, or action to the extent that it arises out of or is based upon a Violation which occurs in reliance upon and in conformity with written information furnished
expressly for use in connection with such registration by any such Holder, underwriter or controlling person. 
 (b) To the extent permitted
by law, each selling Holder will indemnify and hold harmless the Company, each of its directors, each of its officers who has signed the registration statement, each person, if any, who controls the Company within the meaning of the 

  

 8 

 
Securities Act, any underwriter, any other Holder selling securities in such registration statement and any controlling person of any such underwriter or
other Holder, against any losses, claims, damages, or liabilities (joint or several) and reasonable expenses to which any of the foregoing persons may become subject, under the Securities Act, the Exchange Act or other federal or state law, insofar
as such losses, claims, damages, or liabilities (or actions in respect thereto) arise out of or are based upon any Violation, in each case to the extent (and only to the extent) that such Violation occurs in reliance upon and in conformity with
written information furnished by such Holder expressly for use in connection with such registration; and each such Holder will pay, as incurred, any legal or other expenses reasonably incurred by any person intended to be indemnified pursuant to
this subsection 1.10(b), in connection with investigating or defending any such loss, claim, damage, liability, or action; provided, however, that the indemnity agreement contained in this subsection 1.10(b) shall not apply to amounts paid in
settlement of any such loss, claim, damage, liability or action if such settlement is effected without the consent of the Holder, which consent shall not be unreasonably withheld; provided, that in no event shall any indemnity under this subsection
1.10(b) exceed the net proceeds from the offering received by such Holder, except in the case of willful fraud by such Holder. 
 (c)
Promptly after receipt by an indemnified party under this Section 1.10 of notice of the commencement of any action (including any governmental action), such indemnified party will, if a claim in respect thereof is to be made against any
indemnifying party under this Section 1.10, deliver to the indemnifying party a written notice of the commencement thereof and the indemnifying party shall have the right to participate in, and, to the extent the indemnifying party so desires,
jointly with any other indemnifying party similarly noticed, to assume the defense thereof with counsel mutually satisfactory to the parties; provided, however, that an indemnified party (together with all other indemnified parties which may be
represented without conflict by one counsel) shall have the right to retain one separate counsel, with the reasonable fees and expenses to be paid by the indemnifying party, if representation of such indemnified party by the counsel retained by the
indemnifying party would be inappropriate due to actual or potential differing interests between such indemnified party and any other party represented by such counsel in such proceeding. The failure to deliver written notice to the indemnifying
party within a reasonable time of the commencement of any such action, if prejudicial to its ability to defend such action, shall relieve such indemnifying party of any liability to the indemnified party under this Section 1.10, but the
omission so to deliver written notice to the indemnifying party will not relieve it of any liability that it may have to any indemnified party otherwise than under this Section 1.10. 
 (d) If the indemnification provided for in this Section 1.10 is held by a court of competent jurisdiction to be unavailable to an indemnified party
with respect to any loss, liability, claim, damage or expense referred to therein, then the indemnifying party, in lieu of indemnifying such indemnified party hereunder, shall contribute to the amount paid or payable by such indemnified party as a
result of such loss, liability, claim, damage, or expense in such proportion as is appropriate to reflect the relative fault of the indemnifying party on the one hand and of the indemnified party on the other in connection with the statements or
omissions that resulted in such loss, liability, claim, damage or expense as well as any other relevant equitable considerations; provided, that in no event shall any contribution by a Holder under this Subsection 1.10(d) exceed the net proceeds
from the offering received by such Holder, except in the case of willful fraud by such Holder. The relative fault of the indemnifying party and of the 

  

 9 

 
indemnified party shall be determined by reference to, among other things, whether the untrue or alleged untrue statement of a material fact or the omission
to state a material fact relates to information supplied by the indemnifying party or by the indemnified party and the parties’ relative intent, knowledge, access to information, and opportunity to correct or prevent such statement or omission.

 (e) Notwithstanding the foregoing, to the extent that the provisions on indemnification and contribution contained in the underwriting
agreement entered into in connection with the underwritten public offering are in conflict with the foregoing provisions, the provisions in the underwriting agreement shall control. 
 (f) The obligations of the Company and Holders under this Section 1.10 shall survive the completion of any offering of Registrable Securities in a
registration statement under this Section 1, and otherwise. 
 1.11 Reports Under Securities Exchange Act of 1934. With a
view to making available to the Holders the benefits of Rule 144 promulgated under the Securities Act and any other rule or regulation of the SEC that may at any time permit a Holder to sell securities of the Company to the public without
registration or pursuant to a registration on Form S-3, the Company agrees to: 
 (a) make and keep public information available, as those
terms are understood and defined in SEC Rule 144, at all times after ninety (90) days after the effective date of the first registration statement filed by the Company for the offering of its securities to the general public so long as the
Company remains subject to the periodic reporting requirements under Sections 13 or 15(d) of the Exchange Act; 
 (b) take such action,
including the voluntary registration of its Common Stock under Section 12 of the Exchange Act, as is necessary to enable the Holders to utilize Form S-3 for the sale of their Registrable Securities, such action to be taken as soon as
practicable after the end of the fiscal year in which the first registration statement filed by the Company for the offering of its securities to the general public is declared effective; 
 (c) file with the SEC in a timely manner all reports and other documents required of the Company under the Securities Act and the Exchange Act; and

 (d) furnish to any Holder, so long as the Holder owns any Registrable Securities, forthwith upon request (i) a written statement by
the Company that it has complied with the reporting requirements of SEC Rule 144 (at any time after ninety (90) days after the effective date of the first registration statement filed by the Company), the Securities Act and the Exchange Act (at
any time after it has become subject to such reporting requirements), or that it qualifies as a registrant whose securities may be resold pursuant to Form S-3 (at any time after it so qualifies), (ii) a copy of the most recent annual or
quarterly report of the Company and such other reports and documents so filed by the Company, and (iii) such other information as may be reasonably requested in availing any Holder of any rule or regulation of the SEC which permits the selling
of any such securities without registration or pursuant to such form. 
  

 10 

 1.12 Assignment of Registration Rights. The rights to cause the Company to register
Registrable Securities pursuant to this Section 1 may be assigned (but only with all related obligations) by a Holder to a transferee or assignee (a) of at least 1,000,000 shares of such securities, (b) of all securities owned by a
Holder or (c) that is an entity affiliated by common control with such Holder; provided the Company is, within a reasonable time after such transfer, furnished with written notice of the name and address of such transferee or assignee and the
securities with respect to which such registration rights are being assigned. For the purposes of determining the number of shares of Registrable Securities held by a transferee or assignee, the holdings of transferees and assignees of a partnership
who are partners or retired partners of such partnership (including spouses and ancestors, lineal descendants and siblings of such partners or spouses who acquire Registrable Securities by gift, will or intestate succession) shall be aggregated
together and with the partnership; provided that all assignees and transferees who would not qualify individually for assignment of registration rights shall have a single attorney-in-fact for the purpose of exercising any rights, receiving notices
or taking any action under Section 1. 
 1.13 Limitations on Subsequent Registration Rights. From and after the date of
this Agreement, the Company shall not, without the prior written consent of the Holders of a majority of the Series A Preferred Stock (or the Common Stock issuable or issued upon conversion thereof), the Series B Preferred Stock (or the Common Stock
issuable or issued upon conversion thereof) and the Series C Preferred Stock (or the Common Stock issuable or issued upon conversion thereof), voting together as a single class, enter into any agreement with any holder or prospective holder of any
securities of the Company which would allow such holder or prospective holder (a) to include such securities in any registration filed under Section 1.2 hereof, unless under the terms of such agreement, such holder or prospective holder
may include such securities in any such registration only to the extent that the inclusion of his securities will not reduce the amount of the Registrable Securities of the Holders which is included or (b) to make a demand registration which
could result in such registration statement being declared effective prior to the earlier of either of the dates set forth in subsection 1.2(a) or within one hundred twenty (120) days of the effective date of any registration effected pursuant
to Section 1.2. 
 1.14 Market-Standoff Agreement. 
 (a) Market-Standoff Period; Agreement. In connection with the initial public offering of the Company’s securities and upon request of
the Company or the underwriters managing such offering of the Company’s securities, each Holder agrees not to sell, make any short sale of, loan, grant any option for the purchase of, or otherwise dispose of any securities of the Company (other
than those included in the registration) without the prior written consent of the Company or such underwriters, as the case may be, for such period of time (not to exceed 180 days) from the effective date of such registration as may be requested by
the Company or such managing underwriters and to execute an agreement reflecting the foregoing as may be requested by the underwriters at the time of the Company’s initial public offering. 
 (b) Limitations. The obligations described in Section 1.14(a) shall apply only if all officers, directors and five percent
(5%) stockholders of the Company enter into similar agreements, and shall not apply to a registration relating solely to employee benefit plans, or to a registration relating solely to a transaction pursuant to Rule 145 under the Securities
Act. 
  

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 (c) Stop-Transfer Instructions. In order to enforce the foregoing covenants, the Company
may impose stop-transfer instructions with respect to the securities of each Holder (and the securities of every other person subject to the restrictions in Section 1.14(a)). 
 (d) Transferees Bound. Each Holder agrees that prior to the Company’s initial public offering it will not transfer securities of the
Company unless each transferee agrees in writing to be bound by all of the provisions of this Section 1.14. 
 1.15 Termination of
Registration Rights. No Holder shall be entitled to exercise any right provided for in this Section 1 after the earlier of (i) five (5) years following the consummation of a Qualified IPO, or (ii) such time as Rule
144 or another similar exemption under the Securities Act is available for the sale of all of such Holder’s shares during a three (3)-month period without registration and without limitation. 
 2. Covenants of the Company. 
 2.1 Delivery of Financial Statements. The Company shall deliver to each Holder of at least 400,000 shares of Registrable Securities: 
 (a) as soon as practicable, after the end of each fiscal year of the Company, an income statement for such fiscal year, a balance sheet of the Company and statement of stockholder’s equity as of the end of such
year, and a statement of cash flows for such year, such year-end financial reports to be in reasonable detail, prepared in accordance with generally accepted accounting principles (“GAAP”), and audited and certified by an
independent public accounting firm of nationally recognized standing selected by the Company; 
 (b) as soon as practicable, after the end
of each of the first three (3) quarters of each fiscal year of the Company, an unaudited profit or loss statement, a statement of cash flows for such fiscal quarter and an unaudited balance sheet as of the end of such fiscal quarter prepared in
accordance with GAAP; and 
 (c) upon written request, as soon as practicable after the end of each fiscal year, a budget and business plan
for the next fiscal year, prepared on a monthly basis, and, as soon as prepared, any other budgets or revised budgets prepared by the Company. 
 Notwithstanding the foregoing, the Company shall have no obligation to provide any information pursuant to subsection (c) above to any Investor whom the Company believes is developing products in competition with or potentially in
competition with the Company but only to the extent that the Board of Directors of the Company determines that provision of the specific information would have a material adverse competitive effect on the Company. The Investors hereby acknowledge
that the Company may elect to provide different amounts of information relating to the Company to any such Investors. 
  

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 2.2 Inspection. The Company shall permit each Holder of at least 400,000 shares of
Registrable Securities, at such Holder’s expense, to visit and inspect the Company’s properties, to examine its books of account and records and to discuss the Company’s affairs, finances and accounts with its officers and directors,
all at such reasonable times as may be requested by the Investor, as applicable; provided, however, that the Company shall not be obligated pursuant to this Section 2.2 to provide access to any information which it reasonably considers to be a
trade secret or similar confidential information, the disclosure of which would have a material adverse effect on the Company or which would jeopardize the trade secret’s status as such. 
 2.3 Right of First Offer. Subject to the terms and conditions specified in this Section 2.3, the Company hereby grants to each
Holder of at least 1,000,000 shares of Registrable Securities a right of first offer with respect to future sales by the Company of its Shares (as hereinafter defined). A Holder who chooses to exercise the right of first offer may designate as
purchasers under such right itself or its partners or affiliates in such proportions as it deems appropriate. 
 Each time the Company
proposes to offer any shares of, or securities convertible into or exercisable for any shares of, any class of its capital stock (“Shares”), the Company shall first make an offering of such Shares to each Holder in accordance
with the following provisions: 
 (a) The Company shall deliver a notice by certified mail (“Notice”) to the Holders
stating (i) its bona fide intention to offer such Shares, (ii) the number of such Shares to be offered, and (iii) the price and terms, if any, upon which it proposes to offer such Shares. 
 (b) Within 15 calendar days after delivery of the Notice, the Holder may elect to purchase or obtain, at the price and on the terms specified in the
Notice, up to that portion of such Shares which equals the proportion that the number of shares of Common Stock issued and held, or issuable upon conversion and exercise of all convertible or exercisable securities then held, by such Holder bears to
the total number of shares of Common Stock then outstanding (assuming full conversion and exercise of all convertible or exercisable securities). The Company shall promptly, in writing, inform each Holder that purchases all the shares available to
it (each, a “Fully-Exercising Investor”) of any other Holder’s failure to do likewise. During the ten (10)-day period commencing after receipt of such information, each Fully-Exercising Investor shall be entitled to
obtain that portion of the Shares for which Holders were entitled to subscribe but which were not subscribed for by the Holders that is equal to the proportion that the number of shares of Common Stock issued and held, or issuable upon conversion
and exercise of all convertible or exercisable securities then held, by such Fully-Exercising Investor bears to the total number of shares of Common Stock then outstanding (assuming full conversion and exercise of all convertible or exercisable
securities). 
 (c) The Company may, during the 45-day period following the expiration of the period provided in subsection 2.3(b) hereof,
offer the remaining unsubscribed portion of the Shares to any person or persons at a price not less than, and upon terms no more favorable to the offeree than those specified in the Notice. If the Company does not enter into an agreement for the
sale of the Shares within such period, or if such agreement is not consummated 

  

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within 60 days of the execution thereof, the right provided hereunder shall be deemed to be revived and such Shares shall not be offered unless first
reoffered to the Holders in accordance herewith. 
 (d) The right of first offer in this paragraph 2.3 shall not be applicable (i) to
the issuance or sale of up to 5,500,000 shares of Common Stock (or options therefor) since the inception of the Company to employees, consultants and directors, pursuant to plans or agreements approved by the Board of Directors for the primary
purpose of soliciting or retaining their services, (ii) to or after consummation of a Qualified IPO, (iii) to the issuance of securities pursuant to the conversion or exercise of convertible or exercisable securities, (iv) to the
issuance of securities in connection with bona fide acquisitions, mergers, technology licenses or purchases, corporate partnering agreements or similar transactions, the terms of which are approved by the Board of Directors, (v) to the issuance
of securities to financial institutions or lessors in connection with commercial credit arrangements, equipment financings, or similar transactions, (vi) to the issuance or sale of up to an aggregate of 7,800,000 shares of Series D Preferred
Stock of the Company (or warrants therefor), or (vii) to the issuance of securities that, with unanimous approval of the Board of Directors of the Company, are not offered to any existing stockholder of the Company. 
 2.4 Board of Directors. As of the date of this Agreement, and notwithstanding anything to the contrary in the Bylaws of the Company, the
Board of Directors of the Company shall consist of six (6) members, not more than two (2) of which shall be employees of the Company. For so long as OrbiMed Advisors, LLC and its affiliates (collectively “OrbiMed”)
hold at least 384,615 shares of Registrable Securities, it shall have the right to designate one (1) member of the Board of Directors and the OrbiMed designee shall also be a member of each committee of the Board of Directors, including,
without limitation, the Compensation Committee and the Audit Committee. For so long as HBM BioVentures (Cayman) Ltd. and its affiliates (collectively “HBM”) hold at least 365,385 shares of Registrable Securities, it shall
have the right to designate one (1) member of the Board of Directors and the HBM designee shall also be a member of each committee of the Board of Directors, including, without limitation, the Compensation Committee and the Audit Committee. The
Board of Directors shall hold a regularly scheduled meeting at least once every ninety (90) days. Each member of the Board of Directors and the members of each committee of the Board of Directors shall receive notice of each meeting at least
fifteen (15) days before the meeting and such notice shall be provided to each member in the same manner. The Company will reimburse the OrbiMed and HBM directors, as applicable, for their reasonable out-of-pocket and travel expenses incurred
in connection with attending such meetings. 
 2.5 Observation Rights. 
 (a) The Company agrees that for so long as HealthCap III Sidefund KB or its affiliates (collectively “HealthCap”) owns 269,231
shares of Registrable Securities, HealthCap shall be entitled to designate one individual to act as a non-voting observer of the Board of Directors of the Company (the “HealthCap Observer”). The HealthCap Observer shall not
have any right to vote as a director of the Company but shall otherwise be entitled to notice of and to attend all meetings of the Board of Directors of the Company, and to receive any material distributed to the directors in their capacity as
directors of the Company. The Company shall not have any obligation to pay any expenses incurred in connection with the HealthCap Observer’s attendance at such meetings. 
  

 14 

 (b) The Company agrees that for so long as Alta Partners or its affiliates (collectively
“Alta”) owns 326,923 shares of Registrable Securities, Alta shall be entitled to designate one individual to act as a non-voting observer of the Board of Directors of the Company (the “Alta Observer,”
and together with the HealthCap Observer, the “Observers”). The Alta Observer shall not have any right to vote as a director of the Company but shall otherwise be entitled to notice of and to attend all meetings of the Board
of Directors of the Company, and to receive any material distributed to the directors in their capacity as directors of the Company. The Company shall not have any obligation to pay any expenses incurred in connection with the Alta Observer’s
attendance at such meetings. 
 (c) The Observers shall be subject to the obligations of confidentiality set forth in Section 7.14 of
the Subscription Agreement. Notwithstanding Section 2.5(a), the Company reserves the right not to provide information and to exclude the Observers from any meeting or portion thereof if delivery of such information or attendance at such meeting
would result in a loss of trade secret protection for trade secrets of the Company, or would adversely affect the attorney-client privilege between the Company and its counsel. 
 2.6 Termination of Covenants. 
 (a) The covenants set forth in Sections 2.1 through Section 2.5 shall terminate as to each Holder and be of no further force or effect immediately prior to the consummation of a Qualified IPO. 
 (b) The covenants set forth in Sections 2.1 and 2.2 shall terminate as to each Holder and be of no further force or effect when the Company first becomes
subject to the periodic reporting requirements of Sections 13 or 15(d) of the Exchange Act, if this occurs earlier than the events described in Section 2.6(a) above. 
 3. Miscellaneous. 
 3.1 Successors and Assigns. Except as otherwise
provided in this Agreement, the terms and conditions of this Agreement shall inure to the benefit of and be binding upon the respective permitted successors and assigns of the parties (including transferees of any of the Registrable Securities).
Nothing in this Agreement, express or implied, is intended to confer upon any party other than the parties hereto or their respective successors and assigns any rights, remedies, obligations, or liabilities under or by reason of this Agreement,
except as expressly provided in this Agreement. 
 3.2 Amendments and Waivers. Any term of this Agreement may be amended
or waived only with the written consent of the Company and the holders of a majority of the Registrable Securities then outstanding, not including the Founder’s Stock; provided that if (i) such amendment has the effect of affecting the
Founder’s Stock (a) in a manner different than securities issued to the Investors and (b) in a manner adverse to the interests of the holders of the Founder’s Stock, then such amendment shall require the consent of the holder or
holders of a majority of the Founder’s Stock, (ii) such amendment has the effect of affecting the Series A Preferred Stock (j) in a manner different than the Series B Preferred Stock, the Series C Preferred Stock or the Series D
Preferred Stock and (k) in a manner adverse to the interests of the holders of the Series A Preferred Stock, then such amendment shall require the consent of the holder or holders of a majority of the Series A 

  

 15 

 
Preferred Stock, (iii) such amendment has the effect of affecting the Series B Preferred Stock (m) in a manner different than the Series A
Preferred Stock, the Series C Preferred Stock or the Series D Preferred Stock and (n) in a manner adverse to the interests of the holders of the Series B Preferred Stock, then such amendment shall require the consent of the holder or holders of
a majority of the Series B Preferred Stock, (iv) such amendment has the effect of affecting the Series C Preferred Stock (p) in a manner different than the Series A Preferred Stock, the Series B Preferred Stock or the Series D Preferred
Stock and (q) in a manner adverse to the interests of the holders of the Series C Preferred Stock, then such amendment shall require the consent of the holder or holders of a majority of the Series C Preferred Stock, (v) such amendment has
the effect of affecting the Series D Preferred Stock (x) in a manner different than the Series A Preferred Stock, the Series B Preferred Stock or the Series C Preferred Stock and (y) in a manner adverse to the interests of the holders of
the Series D Preferred Stock, then such amendment shall require the consent of the holder or holders of a majority of the Series D Preferred Stock, (vi) such amendment alters Section 2.4, then such amendment shall require the consent of
OrbiMed and HBM, (vi) such amendment alters Section 2.5(a), then such amendment shall require the consent of HealthCap, or (vii) such amendment alters Section 2.5(b), then such amendment shall require the consent of Alta. Any
amendment or waiver effected in accordance with this paragraph shall be binding upon each holder of any Registrable Securities then outstanding, each future holder of all such Registrable Securities, and the Company. 
 3.3 Notices. Unless otherwise provided, any notice required or permitted by this Agreement shall be in writing and shall be deemed
sufficient upon delivery, when delivered personally or by overnight courier or sent by telegram or fax, or forty-eight (48) hours after being deposited in the U.S. mail, as certified or registered mail, with postage prepaid, and addressed to
the party to be notified at such party’s address or fax number as set forth below hereto or as subsequently modified by written notice; provided, however, that registered or certified mail shall not be used to effectuate the delivery of any
such notice to addresses outside the United States. 
 3.4 Severability. If one or more provisions of this Agreement are
held to be unenforceable under applicable law, the parties agree to renegotiate such provision in good faith. In the event that the parties cannot reach a mutually agreeable and enforceable replacement for such provision, then (a) such
provision shall be excluded from this Agreement, (b) the balance of the Agreement shall be interpreted as if such provision were so excluded and (c) the balance of the Agreement shall be enforceable in accordance with its terms.

 3.5 Governing Law. This Agreement and all acts and transactions pursuant hereto shall be governed, construed and
interpreted in accordance with the laws of the State of California, without giving effect to principles of conflicts of laws. 
 3.6
Counterparts. This Agreement may be executed in two or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. 
  

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 3.7 Titles and Subtitles. The titles and subtitles used in this Agreement are used
for convenience only and are not to be considered in construing or interpreting this Agreement. 
 3.8 Aggregation of Stock.
All shares of the Preferred Stock held or acquired by affiliated entities or persons, successor entities, investment funds managed or advised by an Investor, a manager or advisor of an Investor, or an affiliate of such manager or advisor shall be
aggregated together for the purpose of determining the availability of any rights under this Agreement. 
 3.9 Amendment and
Termination of Prior Agreement. The Prior Agreement is hereby amended in its entirety and restated herein. Such amendment and restatement is effective upon the execution of this Agreement by the Company and Investors constituting at least a
majority of the Registrable Securities outstanding, not including the Founder’s Stock, at least a majority of the Series A Preferred Stock, at least a majority of the Series B Preferred Stock and at least a majority of the Series C Preferred
Stock. Upon such execution, all provisions of, rights granted and covenants made in the Prior Agreement (including, without limitation, the Right of First Offer set forth in Section 2.3 of the Prior Agreement) are hereby waived, released and
terminated in their entirety and shall have no further force and effect (including, without limitation, with respect to the Series D Preferred Stock issued pursuant to the Subscription Agreement). 
 3.10 Consent. The execution and delivery of this Agreement by Techne Corporation (“Techne”) shall constitute: (i) a complete
waiver of Techne’s rights under Sections 6.3, 6.4, 6.5, 6.13, 7.1, 7.2(a) and 8 of that certain Investment Agreement, dated November 18, 1997, by and between the Company and Techne; and (ii) consent to the Company’s proposed
Amended and Restated Certificate of Incorporation, in the form attached as Exhibit A to the Subscription Agreement. 
 [Remainder of page
intentionally left blank] 
  

 17 

 The parties have executed this Agreement as of the date first above written. 
  

											
	COMPANY:	 		 	CHEMOCENTRYX, INC.
					
		 		 		 	By:	 	 /s/ Thomas J. Schall

		 		 		 	Name:	 	Thomas J. Schall
		 		 		 	Title:	 	President and Chief Executive Officer
					
		 		 		 	Address:	 	 850 Maude Avenue
 Mountain View, CA
94043

					
	FOUNDER:	 		 		 		 	
					
		 		 		 		 	 /s/ Thomas J. Schall

		 		 		 	Name:	 	Thomas J. Schall
					
		 		 		 	Address:	 	 850 Maude Avenue
 Mountain View, CA
94043

  
 [COUNTERPART SIGNATURE
PAGE TO AMENDED AND RESTATED INVESTORS RIGHTS AGREEMENT] 

																			
	INVESTORS:	 		 	 GIMV NV

		 		 		 		 		 	 (Print or Type Name of Investor)

								
		 		 		 		 		 	/s/ Dirk Boogmans        	 		 	/s/ Patrick Van Beneden        
		 		 		 		 		 	Dirk Boogmans	 		 	Patrick Van Beneden
		 		 		 		 		 	Managing Director	 		 	Executive Vice-President
							
		 		 		 		 		 	Address:	 	 Karel Oomsstraat 37
 2018
Antwerpen
 Belgium

  
 [COUNTERPART SIGNATURE
PAGE TO AMENDED AND RESTATED INVESTORS RIGHTS AGREEMENT] 

																			
	INVESTORS:	 		 	 Adviesbeheer GIMV Life Sciences 2004 NV

		 		 		 		 		 	     (Print or Type Name of Investor)

								
		 		 		 		 		 	/s/ Dirk Boogmans        	 		 	/s/ Patrick Van Beneden        
		 		 		 		 		 	Dirk Boogmans	 		 	Patrick Van Beneden
		 		 		 		 		 	Director	 		 	Director
							
		 		 		 		 		 	Address:	 	 Karel Oomsstraat 37
 2018
Antwerpen
 Belgium

  
 [COUNTERPART SIGNATURE
PAGE TO AMENDED AND RESTATED INVESTORS RIGHTS AGREEMENT] 

											
	INVESTORS:	 		 	 Glaxo Group Limited

		 		 	 (Print or Type Name of Investor)

					
		 		 		 	By:	 	 /s/ Paul Williamson

		 		 		 	Name:	 	Paul Williamson
		 		 		 	Title:	 	 For and on behalf of Edinburgh
 Pharmaceutical Industries Limited
 Corporate Director

					
		 		 		 	Address:	 	 Corporate Secretariat CN8
 GSK House
 980 Great West Road
 Brentford, Middlesex TW8 9GS
 United Kingdom

  
 [COUNTERPART SIGNATURE
PAGE TO AMENDED AND RESTATED INVESTORS RIGHTS AGREEMENT] 

											
	INVESTORS:	 		 	 Techne Corporation

		 		 	 (Print or Type Name of Investor)

					
		 		 		 	By:	 	 /s/ Gregory J. Melsen

		 		 		 	Name:	 	Gregory J. Melsen
		 		 		 	Title:	 	 Vice President-Finance and Chief Financial
 Officer

					
		 		 		 	Address:	 	 614 McKinley Place N.E.
 Minneapolis, MN
55413

  
 [COUNTERPART SIGNATURE
PAGE TO AMENDED AND RESTATED INVESTORS RIGHTS AGREEMENT] 

																			
	INVESTORS:	 		 	 OrbiMed Associates LLC

		 		 		 		 		 	     (Print or Type Name of Investor)

							
		 		 		 		 		 	By:	 	 /s/ Eric A. Bittelman

		 		 		 		 		 	Name:	 	Eric A. Bittelman
		 		 		 		 		 	Title:	 	CFO, OrbiMed Advisors, LLC
							
		 		 		 		 		 	Address:	 	

  
 [COUNTERPART SIGNATURE
PAGE TO AMENDED AND RESTATED INVESTORS RIGHTS AGREEMENT] 

											
	INVESTORS:	 		 	 UBS Juniper Crossover Fund L.L.C.

		 		 	 (Print or Type Name of Investor)

					
		 		 		 	By:	 	 /s/ Eric A. Bittelman

		 		 		 	Name:	 	Eric A. Bittelman
		 		 		 	Title:	 	CFO, OrbiMed Advisors, LLC
					
		 		 		 	Address:	 	

  
 [COUNTERPART SIGNATURE
PAGE TO AMENDED AND RESTATED INVESTORS RIGHTS AGREEMENT] 

											
	INVESTORS:	 		 	 Caduceus Private Investments, LP

		 		 	 (Print or Type Name of Investor)

					
		 		 		 	By:	 	 /s/ Eric A. Bittelman

		 		 		 	Name:	 	Eric A. Bittelman
		 		 		 	Title:	 	 CFO, OrbiMed Capital
 General
Partner

					
		 		 		 	Address:	 	

  
 [COUNTERPART SIGNATURE
PAGE TO AMENDED AND RESTATED INVESTORS RIGHTS AGREEMENT] 

											
	INVESTORS:	 		 	 Thomas Edwards

		 		 	 (Print or Type Name of Investor)

					
		 		 		 	By:	 	 /s/ Thomas Edwards

		 		 		 	Name:	 	Thomas Edwards
		 		 		 	Title:	 	
					
		 		 		 	Address:	 	

  
 [COUNTERPART SIGNATURE
PAGE TO AMENDED AND RESTATED INVESTORS RIGHTS AGREEMENT] 

											
	INVESTORS:	 		 	Alta BioPharma Partners III, L.P.
		 		 	By:	 	Alta California Management III, LLC
					
		 		 		 	By:	 	 /s/ Hilary Strain

		 		 		 	Name:	 	Hilary Strain
		 		 		 	Title:	 	V.P. of Finance & Admin
				
		 		 		 	Alta BioPharma Partners III GmbH & Co.
		 		 		 	Beteiligungs KG
		 		 		 	By:	 	Alta California Management III, LLC
					
		 		 		 	By:	 	 /s/ Hilary Strain

		 		 		 	Name:	 	Hilary Strain
		 		 		 	Title:	 	V.P. of Finance & Admin
				
		 		 		 	Alta Embarcadero BioPharma Partners III, LLC
					
		 		 		 	By:	 	 /s/ Hilary Strain

		 		 		 	Name:	 	Hilary Strain
		 		 		 	Title:	 	V.P. of Finance & Admin
					
		 		 		 	Address:	 	 One Embarcadero Center, Suite 3700
 San Francisco, CA
94111

  
 [COUNTERPART SIGNATURE
PAGE TO AMENDED AND RESTATED INVESTORS RIGHTS AGREEMENT] 

											
	INVESTORS:	 		 	 HBM BioVentures (Cayman) Ltd.

		 		 	(Print or Type Name of Investor)
					
		 		 		 	By:	 	 /s/ John Arnold

		 		 		 	Name:	 	John Arnold
		 		 		 	Title:	 	Chairman and Managing Director
					
		 		 		 	Address:	 	 Centennial Towers, 3rd Floor
 2454 West Bay
Road
 Grand Cayman, Cayman Islands

  
 [COUNTERPART SIGNATURE
PAGE TO AMENDED AND RESTATED INVESTORS RIGHTS AGREEMENT] 

											
	INVESTORS:	 		 	HealthCap 1999 KB
					
		 		 		 	By:	 	 /s/ [illegible] [illegible]

		 		 		 	Name:	 	[illegible] [illegible]
		 		 		 	Title:	 	Partner                    Partner
					
		 		 		 	Address:	 	 Strandvagen 5B
 SE-11451 Stockholm
 SWEDEN

			
		 		 	HealthCap III Sidefund KB
					
		 		 		 	By:	 	 /s/ [illegible] [illegible]

		 		 		 	Name:	 	[illegible] [illegible]
		 		 		 	Title:	 	Partner                    Partner
					
		 		 		 	Address:	 	 Strandvagen 5B
 SE-11451 Stockholm
 SWEDEN

			
		 		 	Odlander, Fredrikson & Co. AB as a member and on behalf of all the members, if any, of the OFCO Club
					
		 		 		 	By:	 	 /s/ [illegible] [illegible]

		 		 		 	Name:	 	[illegible] [illegible]
		 		 		 	Title:	 	Partner                    Partner
					
		 		 		 	Address:	 	 Strandvagen 5B
 SE-11451 Stockholm
 SWEDEN

			
		 		 	Odlander, Fredrikson & Co. AB as a member and on behalf of all the members, if any, of the OFCO Club III Sidefund
					
		 		 		 	By:	 	 /s/ [illegible] [illegible]

		 		 		 	Name:	 	[illegible] [illegible]
		 		 		 	Title:	 	Partner                    Partner
					
		 		 		 	Address:	 	 Strandvagen 5B
 SE-11451 Stockholm
 SWEDEN

  
 [COUNTERPART SIGNATURE
PAGE TO AMENDED AND RESTATED INVESTORS RIGHTS AGREEMENT] 

											
	INVESTORS:	 		 	 Jennison Health Sciences Fund (“Fund”), a series of Jennison Sector Funds, Inc.

			
		 		 	 By: Jennison Associates LLC (“Jennison”), as Sub-advisor to the Fund

		 		 	 (Print or Type Name of Investor)

					
		 		 		 	By:	 	 /s/ David Chan

		 		 		 	Name:	 	David Chan
		 		 		 	Title:	 	Managing Director of Jennison and Portfolio Manager of the Fund
					
		 		 		 	Address:	 	 c/o Jennison Associates LLC
 466 Lexington
Avenue
 New York, New York 10017

  
 [COUNTERPART SIGNATURE
PAGE TO AMENDED AND RESTATED INVESTORS RIGHTS AGREEMENT] 

											
	INVESTORS:	 		 	 Pacific Select Fund, Health Sciences Portfolio (“Fund”)

			
		 		 	 By: Jennison Associates LLC (“Jennison”), as Sub-advisor to the Fund

		 		 	 (Print or Type Name of Investor)

					
		 		 		 	By:	 	 /s/ David Chan

		 		 		 	Name:	 	David Chan
		 		 		 	Title:	 	Managing Director of Jennison and Portfolio Manager of the Fund
					
		 		 		 	Address:	 	 c/o Jennison Associates LLC
 466 Lexington
Avenue
 New York, New York 10017

  
 [COUNTERPART SIGNATURE
PAGE TO AMENDED AND RESTATED INVESTORS RIGHTS AGREEMENT]

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