Document:

Exhibit 10.2

 

 

BONDS ISSUE AGREEMENT

 

By and between

 

Biophytis S.A.

 

as Issuer

 

and

 

Kreos Capital V (UK) LTD.

 

As Subscriber

 

September 10th 2018

 

 

 

 

Table of contents

 

	
1.
    	
Definitions and   interpretation
    	
4
    
	
 
    	
 
    	
 
    
	
2.
    	
Issue and subscription
    	
7
    
	
 
    	
 
    	
 
    
	
3.
    	
Purpose of the Issue
    	
8
    
	
 
    	
 
    	
 
    
	
4.
    	
Ranking
    	
8
    
	
 
    	
 
    	
 
    
	
5.
    	
Interest
    	
8
    
	
 
    	
 
    	
 
    
	
6.
    	
Repayment, purchase and   cancellation
    	
9
    
	
 
    	
 
    	
 
    
	
7.
    	
Taxation
    	
9
    
	
 
    	
 
    	
 
    
	
8.
    	
Undertakings
    	
10
    
	
 
    	
 
    	
 
    
	
9.
    	
Events of default
    	
10
    
	
 
    	
 
    	
 
    
	
10.
    	
Register and   certificates
    	
12
    
	
 
    	
 
    	
 
    
	
11.
    	
Transmission and   transfer
    	
13
    
	
 
    	
 
    	
 
    
	
12.
    	
Procedures for payment
    	
13
    
	
 
    	
 
    	
 
    
	
13.
    	
Rights of single or   multiple Bondholders and Warrant Holders
    	
13
    
	
 
    	
 
    	
 
    
	
14.
    	
Remedies and waivers
    	
14
    
	
 
    	
 
    	
 
    
	
15.
    	
Severability
    	
14
    
	
 
    	
 
    	
 
    
	
16.
    	
Notices
    	
14
    
	
 
    	
 
    	
 
    
	
17.
    	
Law and jurisdiction
    	
16
    
	
 
    	
 
    	
 
    
	
List of Appendixes
    	
17
    

 

2

 

Bonds Issue Agreement

 

This agreement (hereinafter referred to as the “Agreement” or “Bonds Issue Agreement”) is entered into on September 10th, 2018, by and between:

 

1.                            Biopthytis S.A., a limited company (société anonyme) incorporated under the laws of France, with a share capital of EUR 2,692,682.60 having its registered office at 14, avenue de l’Opéra — 75001 Paris, France, registered under single identification number 492 002 225 RCS Paris, listed on the Euronext Growth organized multilateral trading facility under ISIN code FR0012816825, represented by Mr. Stanislas Veillet, in his capacity of chief executive officer (Président Directeur Général),

 

(hereinafter referred to as the “Issuer”)

 

ON THE FIRST PART

 

AND

 

2.                            Kreos Capital V (UK) Limited, a private limited company incorporated under the laws of England, having its registered office at 5th Floor, 25-28 Old Burlington Street, London W1S 3AN, United Kingdom, registered under identification number 09728300, represented by Mr. Maurizio Petitbon, in his capacity of Director, duly authorised for the purposes hereof;

 

(hereinafter referred to as the “Subscriber” or “Kreos”)

 

ON THE SECOND PART

 

Issuer and Subscriber being hereinafter referred to individually as a “Party” and collectively as the “Parties”.

 

Whereas

 

(A)                     The Subscriber is a venture debt provider, the business of which consists in making investments in high technology and life science companies throughout Europe.

 

(B)                     The Issuer is a French société anonyme, created in 2006, specializing in creating drugs to treat degenerative illnesses associated with aging for which no treatment is available to date. Its most advances programmes relate to sarcopenia (loss of muscle functionality) and age-related macular degeneration (armd).

 

(C)                     In order to finance the development of the Issuer’s business in general, the Subscriber has agreed to subscribe to an issue of Bonds and Warrants by the Issuer for a nominal amount of up to ten million euros (EUR 10,000,000.00) subject to and upon the terms and conditions of the venture loan agreement entered into between the Parties on the date herof (hereinafter referred to as the “Venture Loan Agreement”).

 

(D)                     The Parties have agreed upon the terms and conditions of the Issue as set forth herein.

 

3

 

NOW, THEREFORE, IT HAS BEEN AGREED AS FOLLOWS:

 

1.                            Definitions and interpretation

 

1.1                     In this Agreement, unless the context otherwise specifically provides, the following expressions shall have the following meanings:

 

	
Agreement
    	
 
    	
shall have the meaning set forth in the preamble;
    
	
 
    	
 
    	
 
    
	
Bondholder(s)
    	
 
    	
means the person(s), including the Subscriber and   any subsequent person(s) entered in the Register which the Issuer is   required to maintain under this Agreement, as holder(s) of Bonds and as   may be represented by the bondholders’ representative (représentant   de la masse);
    
	
 
    	
 
    	
 
    
	
Bonds
    	
 
    	
means the bonds (obligations   within the meaning assigned in article 213-5 of the French monetary and   financial Code) issued in Euros by the chief executive officer (directeur general) of the Issuer in accordance with this   Agreement and decisions of the board of directors (conseil   d’administration) of the Issuer dated July 10th 2018 empowering the chief executive officer   (directeur general) of the Company to   negotiate and enter into a venture loan agreement of EUR 10,000,000 divided   into 4 tranches with 10% of warrants (bons de souscription   d’actions) and a pledge over business division pursuant to   decisions of the Issuer’s general meeting dated June 4th 2018 empowering, through its 8th resolution, the Issuer’s board of directors   (conseil d’administration) to issue   warrants giving access to the Issuer’s capital;
    
	
 
    	
 
    	
 
    
	
Business Day
    	
 
    	
means a day (excepting Saturdays and Sundays) on   which banks operate in Paris;
    
	
 
    	
 
    	
 
    
	
Change of Control
    	
 
    	
means the de-listing of the Issuer;
    
	
 
    	
 
    	
 
    
	
Discharge Date
    	
 
    	
means with respect to any drawdown under any Tranche,   the 36th Repayment Date (or such date of actual early   payment in case of a Prepayment or acceleration of the Bonds or more   generally such earlier date or dates as the same shall become repayable in   accordance with this Agreement and/or the Venture Loan Agreement);
    
	
 
    	
 
    	
 
    
	
Drawdown Date
    	
 
    	
means with respect to any drawdown under any   Tranche, the day on which the Bonds are subscribed and paid up by the   Subscriber;
    
	
 
    	
 
    	
 
    
	
Drawdown Notice
    	
 
    	
means a notice from Issuer requesting Subscriber to   subscribe to Bonds in accordance with this Agreement;
    
	
 
    	
 
    	
 
    
	
Event of Default
    	
 
    	
means any of those events set out in Article 9   (Events of Default);
    
	
 
    	
 
    	
 
    
	
Final Redemption Date
    	
 
    	
means the date on which all amounts due under the   Issue Documents have been unconditionally and irrevocably paid and discharged   in full;
    
	
 
    	
 
    	
 
    
	
First Interest Payment Date
    	
 
    	
means with respect to any drawdown under any   Tranche, the first day of a calendar month being or following the date of   drawdown, as specified in the Drawdown Notice;
    

 

4

 

	
Interest Payment
    	
 
    	
means interest payments due by the Issuer to the   Subscriber pursuant to this Agreement;
    
	
 
    	
 
    	
 
    
	
Interest Payment Date
    	
 
    	
means with respect to any drawdown under any   Tranche, the First Interest Payment Date, and then the first Business Day of   each subsequent calendar month;
    
	
 
    	
 
    	
 
    
	
Interest Period
    	
 
    	
means with respect to any drawdown under any   Tranche, a period commencing on and including an Interest Payment Date and   ending on the day prior to the next following Interest Payment Date. Every   Interest Period shall have a duration of one calendar month, being however   specified that (i) in the event any Drawdown Date would not be the First   Interest Payment Date, interest will accrue on the period elapsing between   the Drawdown Date and the First Interest Payment Date in accordance with the   provisions of Article 5.1 and 5.2, and (ii) in the event the   Discharge Date is later than the 36th Interest Period, the last Interest Period   will commence on the date of the Interest Payment Date immediately preceding   the Discharge Date and end on such Discharge Date;
    
	
 
    	
 
    	
 
    
	
Issue
    	
 
    	
means the issue of (i) Warrants and   (ii) 10,000,000 Bonds carried out by the chief executive officer (directeur général) of the Issuer pursuant to this   Agreement;
    
	
 
    	
 
    	
 
    
	
Issue Documents
    	
 
    	
has the meaning ascribed to it in the Venture Loan   Agreement;
    
	
 
    	
 
    	
 
    
	
Material Adverse Effect
    	
 
    	
means a material adverse effect on either the   business / or the operations of the Issuer, and its ability to comply with   any of its payment obligations under the Agreement;
    
	
 
    	
 
    	
 
    
	
Person
    	
 
    	
shall mean and include an individual, a partnership,   a corporation, a business trust, a joint stock company, a limited liability   company, an unincorporated association or other entity and any domestic or   foreign national, state or local government, any political subdivision   thereof, and any department, agency, authority or bureau of any of the   foregoing;
    
	
 
    	
 
    	
 
    
	
Prepayment
    	
 
    	
has the meaning ascribed to it in Article 6.3;
    
	
 
    	
 
    	
 
    
	
Register
    	
 
    	
has the meaning ascribed to it in Article 10.2;
    
	
 
    	
 
    	
 
    
	
Repayment Date
    	
 
    	
means with respect to any drawdown under any   Tranche, for the first time, April 1st, 2019 (or, as regards any   Tranche drawn under the provisions of clause 2.5, the first Interest Payment   Date in, relation to the relevant Tranche), and then subsequent Interest   Payment Dates (or the date of any Prepayment or acceleration of the Bonds or   more generally such earlier date or dates as the same shall become repayable   in accordance with this Agreement and/or the Venture Loan Agreement);
    
	
 
    	
 
    	
 
    
	
Security Documents
    	
 
    	
means any document entered into by any person   (including subsidiaries, if any) from time to time creating any Security   Interest, directly or indirectly, for the obligations of the Issuer under the   Venture Loan Agreement;
    
	
 
    	
 
    	
 
    
	
Security Interest
    	
 
    	
means any mortgage, charge, assignment, pledge,   lien, contractual right of set-off, hypothecation, encumbrance, priority or   other security interest or any 
    

 

5

 

	
 
    	
 
    	
arrangement which has substantially the same   commercial or substantive effect as the creation of security;
    
	
 
    	
 
    	
 
    
	
Subscriber(s)
    	
 
    	
means Kreos Capital V (UK) Limited any subsequent   Person(s) entered in the securities register which the Issuer under this   Agreement is required to maintain, as holder(s) of the Bonds;
    
	
 
    	
 
    	
 
    
	
Terms and Conditions of the Warrants
    	
 
    	
means the terms and conditions of the Warrants as   set forth in Schedule2.2 (b) hereof;
    
	
 
    	
 
    	
 
    
	
Tranche(s)
    	
 
    	
means (i) individually Tranche A, Tranche B,   Tranche C and Tranche D and (ii) collectively Tranches A and/or B and/or   C and/or D and/or Tranche under Article 2.6;
    
	
 
    	
 
    	
 
    
	
Tranche A
    	
 
    	
has the meaning ascribed to it in Article 2.2;
    
	
 
    	
 
    	
 
    
	
Tranche B
    	
 
    	
has the meaning ascribed to it in Article 2.3;
    
	
 
    	
 
    	
 
    
	
Tranche C
    	
 
    	
has the meaning ascribed to it in Article 2.4;
    
	
 
    	
 
    	
 
    
	
Tranche D
    	
 
    	
has the meaning ascribed to it in Article 2.5;
    
	
 
    	
 
    	
 
    
	
Warrants
    	
 
    	
means the warrants (bons de   souscription d’actions governed by the provisions of article   228-91 of the French commercial Code) issued in Euros by the chief executive   officer (directeur general) of the Issuer in   accordance with this Agreement and decisions of the board of directors (conseil d’administration) of the Issuer dated July 10th 2018 empowering the chief executive officer   (directeur general) of the Company to   negotiate and enter into a venture loan agreement of EUR 10,000,000 divided   into 4 tranches with 10% of warrants (bons de souscription   d’actions) and a pledge business division pursuant to decisions of   the Issuer’s general meeting dated June 4th 2018 empowering, through its 8th resolution, the Issuer’s board of directors   (conseil d’administration) to issue   warrants giving access to the Issuer’s capital.
    

 

1.2                     In this Agreement, except as otherwise provided or where clearly inconsistent in the light of the context:

 

(i)                           words importing the singular include the plural and vice versa;

 

(ii)                        words denoting gender include every gender;

 

(iii)                     words denoting persons include bodies corporate or unincorporate;

 

(iv)                    a section, clause, sub-clause or Appendix is to a section, clause, sub-clause or Appendix, as the case may be, of or to this Bonds Issue Agreement;

 

(v)                       any provision of a statute shall be construed as a reference to that provision as amended, modified, re-enacted or extended from time to time;

 

(vi)                    words and expressions in the French language defined in the French Commercial Code (Code de commerce) or the French Monetary and Financial Code (Code monétaire et financier) as amended shall bear the same meanings herein, and

 

(vii)                 capitalised terms not defined herein shall have the meaning given to them in the Venture Loan Agreement.

 

6

 

1.3                     The headings in this Agreement are for ease of reference only and shall not affect the construction of this Agreement.

 

1.4                     Should any conflicts occur between this Agreement and any of the Issue Documents, the Parties agree that the Venture Loan Agreement’s provisions shall prevail.

 

2.                          Issue and subscription

 

2.1                     The Bonds shall be issued, in four Tranches, by the Issuer in registered form exclusively reserved to the Subscriber, for a maximum nominal amount of ten million Euros (EUR 10,000,000), with a par value of one Euro (EUR 1.00) per Bond as decided by the Issuer’s chief executive officer (directeur general) in accordance with article L.228-40 of the French commercial Code (Code de commerce) and article L. 411-2 II 2 of the French Monetary and Financial Code (Code monétaire et financier). The Bonds will confer rights to the Subscriber and any subsequent Bondholder as from their subscription.

 

2.2                     Tranche A

 

Subscriber will subscribe to a first tranche (the “Tranche A”) of (i) two millions fifty-seven thousand five hundred twenty-three (2,057,523) Bonds and (ii) four hundred forty-two thousand four hundred seventy-seven (442,477) Bonds with Warrants attached, in one single drawdown, subject to the deliveries set forth in Article 3 of the Venture Loan Agreement, pursuant to a Drawdown Notice in accordance with the template attached as Appendix 2.2 (a) hereto. Warrants, having the characteristics described in Appendix 2.2 (b), shall be attached to the Tranche A. Upon issuance, the Warrants shall be detached from the Tranche A Bonds.

 

2.3                     Tranche B

 

Subscriber will have the possibility, at Issuer’s request, to subscribe to a second tranche (the “Tranche B”) of two million five hundred thousand (2,500,000) Bonds in one single drawdown of EUR 2,500,000, subject to the conditions precedent set forth in Article 4 of the Venture Loan Agreement pursuant to a Drawdown Notice in accordance with the template attached as Appendix 2.2 (a) hereto.

 

2.4                     Tranche C

 

Subscriber will have the possibility, at Issuer’s request, to subscribe to a third tranche (the “Tranche C”) of two million five hundred thousand (2,500,000) Bonds in one single drawdown of EUR 2,500,000, subject to the conditions precedent set forth in Article 4 of the Venture Loan Agreement pursuant to a Drawdown Notice in accordance with the template attached as Appendix 2.2 (a) hereto.

 

2.5                     Tranche D

 

Subscriber will have the possibility, at Issuer’s request, to subscribe a fourth tranche (the “Tranche D”) to two million five hundred thousand (2,500,000) Bonds in one single drawdown of EUR 2,500,000, subject to the conditions precedent set forth in Article 4 of the Venture Loan Agreement pursuant to a Drawdown Notice in accordance with the template attached as Appendix 2.2 (a) hereto.

 

2.6                     In the event one or several of the Tranches has not been drawn by Issuer during their availability period, the Issuer may defer the drawdown of one single undrawn Tranche, subject to the deliveries and conditions precedent set forth in Articles 3 and 4 of the Venture Loan Agreement, and draw such Tranche in a single drawdown, at any time from and subject to the cumulative fulfilment of such deliveries and conditions between April 1st, 2019 and June 30st, 2019, pursuant to a Drawdown Notice in accordance with the template attached as Appendix 2.2 (a) hereto.

 

7

 

2.7                     Subscription of the Bonds and Warrants will be wholly paid up by the Subscriber, by bank transfer, to the following account:

 

Banque NEUFLIZE OBC

3, avenue Hoche

75008 Paris, France

IBAN : FR76 3078 8001 0008 7421 1000 162

BIC : NSMBFRPPXXX

 

Concurrently with such transfer, the Subscriber shall send to the Issuer a subscription form in the form of Appendix 2.7 hereto.

 

3.                          Purpose of the Issue

 

3.1                     The Issuer shall apply the proceeds of Tranche A, Tranche B, Tranche C and Tranche D towards general working capital purposes, and agrees that it will not use the whole or any part of the proceeds of the Issue in contravention of any applicable law.

 

3.2                     Without prejudice to the above, the Subscriber shall not be under any obligation to concern itself with the application of the proceeds of the Issue.

 

4.                            Ranking

 

Each of the Bonds shall rank pari passu equally and rateably inter se without any discrimination or preference and as direct, unconditional, unsubordinated obligations, secured as set out in the Security Documents, being specified any existing loans between the Issuer and any Subsidiary (as defined in the Venture Loan Agreement) will be subordinated to and rank after the rights and interests created by the Issuer in favour of the Bondholder(s) under the Issue Documents.

 

5.                          Interest

 

5.1                     Interest on each drawdown under each Tranche shall accrue on the principal moneys outstanding on the relevant Bonds at a fixed interest rate of ten per cent (10.00 %) per annum, payable in cash, in a number of instalments equal to thirty six, increased by the number of Interest Periods elapsed between the First Interest Payment Date and March 31st, 2019, as set out in the payment schedule attached as Appendix 5.1, commencing with fixed interest payments until March 31st, 2019, and followed by thirty six (36) decreasing interest payments based on a 3.2001 % repayment rate on the outstanding nominal and interest, as set out in column 8 (Interest) of the payment schedule attached as Appendix 5.1.

 

5.2                     In the event that the drawdown on a Tranche is deferred in accordance with the provisions of clause 2.6, no fixed interest payments shall be due and the interest shall be payable at a fixed interest rate of ten per cent (10.00 %) per annum on thirty-six (36) decreasing interest payments based on a 3.2001 % repayment rate on the outstanding nominal and interest, as set out in column 8 (Interest) of the payment schedule attached as Appendix 5.1. starting on the First Interest Payment Date pertaining to such deferred Tranche.

 

5.3                     In both of the situations set out in clause 5.1 and 5.2, in the event any amount is drawn prior to the first day of any month, interest shall accrue on moneys outstanding as of their effective transfer date to Issuer until the First Interest Payment date (on the basis of a daily 1/30th of the monthly fixed interest payment set out in clause 5.1) and shall be paid by way of set-off with the funds to be transferred by Subscriber to Issuer.

 

8

 

5.4                     Interest shall be paid in respect of each Interest Period on each Interest Payment Date. To the extent interest is not paid for at least one (1) year on any Interest Payment Date, further interest shall accrue on any such interest not so paid in accordance with Article 1343-2 of the French Civil Code (Code civil) at the rate specified in Article 5.7 hereunder. Interest shall be calculated on the basis of a three hundred and sixty-five (365) day year and shall be deemed to accrue on the Bonds from day to day.

 

5.5                     Each interest payment shall be made to the Subscriber(s), on each Interest Payment Date before 11.00 AM Paris time, and the Subscriber shall be deemed, for the purposes of this Agreement, to be the holder, on such date for payment of interest, of the Bonds held by him on such preceding date notwithstanding any intermediate transfer or transmission of any such Bonds.

 

5.6                     Interest on the principal moneys outstanding on any Bonds becoming liable to repayment under any provision hereof shall cease to accrue as from the due date for repayment of such principal moneys unless repayment of any such principal moneys and/or payment of any such interest is not effected in which event interest shall continue to accrue at the rate specified in Article 5.7 on the amount which remains unpaid until actual payment in full of such principal moneys and interest is made.

 

5.7                     Should the Issuer fail to pay any outstanding nominal sum (including the amount payable by Issuer under clause 10.4 of the Venture Loan Agreement) on its due date for payment under this Agreement, the Issuer shall pay interest on such sum from the due date up to the date of actual payment (as well after as before judgment) at a rate which shall be the higher of (i) three times the legal interest rate and (ii) the sum of (a) three per cent (3 %) per annum and (b) the interest rate set out under Article 5.1 above.

 

6.                          Repayment, purchase and cancellation

 

6.1                     For each Tranche, the Issuer shall repay the Bonds at their principal amount on a monthly basis, in thirty-six (36) increasing repayments, being specified that each instalment is due in advance, on each Repayment Date in accordance with the payment schedule attached as Appendix 5.1, the last repayment from the Issuer having to occur on the 35th Interest Payment Date as an effect of clause 6.5.

 

6.2                     The repayments shall be made net to Subscriber pursuant to Article 7.

 

6.3                     The Issuer shall have the right, at any time but with no less than thirty (30) days prior notice to Subscriber, to prepay or purchase the Bonds, exclusively in whole (a “Prepayment”). The Prepayment shall be equal to (i) the principal outstanding amount under the Issue, plus (ii) the sum of all interest repayments which would have been paid throughout the remainder of the term of the relevant Tranche discounted by ten percent (10.00%) per annum. A discount calculation example is attached as Appendix 6.3 hereto.

 

6.4                     Any Bonds repaid or purchased by the Issuer shall be cancelled and the Issuer shall not be entitled to keep the same alive for the purposes of re-issue or to re-issue the same.

 

6.5                     Notwithstanding any contrary provision in this Agreement, the last instalment (including principal and interest) under each Tranche shall be paid by Issuer in advance, by way of set-off with the funds to be transferred by Subscriber to Issuer on each Drawdown Date, as a deposit to be held by Subscriber and applied in or towards payment of the last monthly repayment.

 

7.                          Taxation

 

7.1                     The Subscriber being established outside the Republic of France, interest and other revenues in respect of the Bonds benefit under present law from the exemption provided for in Article 131 quarter and Article 125 A III of the French General Tax Code (Code Général des Impôts) from withholding tax. Accordingly, such payments do not give right to any tax credit under any French tax law.

 

9

 

7.2                     The Subscriber shall provide Issuer with the tax residence statement as may be required by French tax authorities in order for the Issuer to rely on the exemption mentioned in Article 7.1.

 

7.3                     Except where directly caused by the Subscriber (including the change of tax residence, absence of delivery of the tax residence statement referred to in Article 7.2), in the event that it is required that payments of principal or interest in respect of the Bonds be subject to withholding or deduction in respect of any taxes or duties whatsoever (a “Tax Deduction”), the Issuer will pay such additional amounts as may be necessary so that the Subscriber, after such withholding or deduction, receive the full amount due to the Subscriber. For that purpose, the amount of interest due to the Subscriber shall be increased in order that the net amount received by the Subscriber after the required withholding or deduction shall equal the amount that would have been received, had such withholding or deduction not been made, it being specified that no additional payment shall be made should the Subscriber benefit from a reimbursement of such Tax Deduction.  The provisions of this Article 7.3 shall not apply if (i) any regulation applicable in the country of residence of the Issuer prohibits the Issuer from assuming the charge of the Tax Deduction, and/or (ii) the Tax Deductions which represent a tax credit, or can be used as a deduction or offset against the Subscribers’ tax.

 

7.4                     However, no such additional amounts shall be payable with respect to any Bond to the Subscriber (or to a third party on behalf of the Subscriber) who is liable to such taxes or duties in respect of such Bond by reason of his having some connection with the Republic of France other than merely being the holder of the Bond — to be clarified.

 

8.                          Undertakings

 

The Issuer undertakes with the Subscriber that, from the date of this Agreement and for so long as any amount is or may be outstanding under this Agreement, it shall comply with the commitments set forth in Article 5 (Commitments) of the Venture Loan Agreement.

 

9.                          Events of default

 

Each of the following events, facts or circumstances constitutes an Event of Default:

 

9.1                     Non-payment

 

The Issuer fails, after being notified by the Subscriber, to pay in full on the due date any sum due from it under this Agreement in the currency and in the manner specified in this Agreement save where such payment is made within five (5) Business Days of the due date and such failure is solely due to an administrative or systems error in the transmission of funds;

 

9.2                     Breach of financial information obligations

 

The Issuer fails to duly perform or comply with any of the financial information obligations expressed to be assumed by it in Article 5.2 of the Venture Loan Agreement and where such non-performance or non-compliance is capable of remedy, has not been remedied within ten (10) Business Days of the notice of that breach by the Subscriber to the Issuer;

 

9.3                     Breach of other obligations

 

The Issuer fails to duly perform or comply with any other material obligation expressed to be assumed by it in any of the Issue Documents to which it is a party and where such non-performance or non-compliance, is capable of remedy, has not been remedied within ten (10) Business Days of the notice of that breach by the Subscriber to the Issuer;

 

10

 

9.4                     Breach of ranking obligations

 

The Issuer is in breach of the ranking obligations under Article 4.1.8 (Commitments) of the Venture Loan Agreement and/or Article 4 (ranking) of this Agreement.

 

9.5                   Cross-default

 

Any indebtedness of the Issuer exceeding two hundred and fifty thousand euros (€1250,000), including, but not exclusively, as a result of any loan taken out, any bond agreement entered into, or any lease agreement entered into as the lessee, is not paid when due or within any applicable grace period, any indebtedness of the Issuer is declared to be or otherwise becomes due and payable before its specified maturity as a result of an event of default, or any creditor or creditors of the Issuer become entitled to declare indebtedness of the Issuer, due and payable before its specified maturity as a result of an event of default, except where (i) such event of default results from a breach of its obligations by a business counterparty or (ii) a business counterpart is a provider of the Issuer, and the absence of payment is made in the ordinary course of business and does not exceed five (5) Business Days;

 

9.6                     Insolvency

 

If and when applicable, the Issuer is unable to pay its debts as they fall due, with its available assets (“état de cessation des paiements”) or otherwise admits its inability to pay its debts as they fall due, or commences negotiations with any one or more of its creditors with a view to the general readjustment or rescheduling of its Indebtedness, or makes a general assignment for the benefit of, or a composition with, its creditors, whether or not through the appointment of an administrator (“administrateur judiciaire” ou “liquidateur judiciaire”), in the framework of a conciliation or safeguard procedure.

 

9.7                     Cessation of business

 

If the Issuer ceases to carry on the business it carries on at the date hereof as mentioned in section (B) of the preamble hereof, or enters into any new business that is not directly related to such business;

 

9.8                     Change of control

 

Unless otherwise agreed by the Subscriber, which opinion shall be delivered within ten (10) Business Days from the receipt by the Subscriber of a notification informing him of the potential Change of Control and the circumstances thereof, there is a Change of Control of the Issuer;

 

9.9                     Validity of agreement

 

At any time any act, condition or thing required to be done, fulfilled or performed by it in order:

 

	
(i)
    	
 
    	
to enable the Issuer lawfully to enter into,   exercise its rights under or perform the obligations expressed to be assumed   by it in the Issue Documents to which it is a party;
    
	
 
    	
 
    	
 
    
	
(ii)
    	
 
    	
to ensure that the obligations expressed to be   assumed by the Issuer in the Issue Documents to which it is a party are and   remain legal, valid and binding;
    
	
 
    	
 
    	
 
    
	
(iii)
    	
 
    	
to make the Issue Documents to which it is a party   admissible in evidence in France;
    

 

is not done, fulfilled or performed within any time available to ensure compliance with the same;

 

11

 

9.10              Unlawfulness

 

If, at any time it is or becomes unlawful for the Issuer to perform or comply with any or all of its material obligations under the Issue Documents or if any of the material obligations of the Issuer under the Issue Documents are not, or cease to be, legal, valid and binding;

 

9.11              Material adverse change

 

The occurrence of any facts, circumstances event which have or which can reasonably be considered as likely to have a Material Adverse Effect (including (i) any payment default or event or circumstance occurs which, with the giving of notice, lapse of time, determination of materiality, the fulfillment of any other applicable condition or any combination of the foregoing constitutes a default (howsoever described) under any contract (including, without limitation, any leasing contracts) to an extent or in a manner which will have or which can reasonably be considered as likely to have a Material Adverse Effect, or (ii) any litigation, arbitration or administrative proceedings are commenced which give grounds in the reasonable opinion of an independent lawyer appointed by both parties for belief that a Material Adverse Effect will result there from); it being understood that as from the day the notice of that circumstance is given by the Subscriber to the Issuer, a ten (10) Business Day period of grace during which the Subscriber does not seek the repayment of the sums owed by the Issuer under the Issue Documents nor enforce any of its Security Interest is then granted to the Issuer in order for him, or as the case may be, its shareholders, either (i) to organize the repayment of these sums or (ii) to take all necessary actions which in the sole reasonable opinion of the Subscriber are of nature to enable the Issuer to continue to perform the Agreement in all its material provisions until the Final Redemption Date;

 

9.14            Occurrence of an Event of Default

 

In case an Event of Default has occurred, or, in the event remedial periods are provided herein, is continuing after such remedial periods has elapsed, the Subscriber may notify such Event of Default to the Issuer and at its discretion, decide that all moneys outstanding under the Bonds shall become immediately repayable and all interest accrued but unpaid shall become immediately payable, together with any other sums then owed by the Issuer under any Issue Documents, subject to Subscriber (or in case of a “masse”, the Subscribers representative) giving written notice to the Issuer to that effect no sooner than five (5) Business Days from notification of the Event of Default, provided, where such Event of Default may be remedied, that has not been remedied to the reasonable satisfaction of the Subscriber.

 

10.                     Register and certificates

 

10.1              The Issuer shall at all time keep at its registered office an accurate register of the Bonds (the “Register”) in accordance with provisions of article L. 228-1 al. 6 of the French commercial Code (Code de commerce) or have such Register duly held by an authorised agent.

 

10.2              The Issuer shall at all time ensure that the Register shows in accordance with French law:

 

(i)                           All transfers, redemption and changes of ownership in respect of the Bonds;

 

(ii)                        The names and addresses of all Bondholders.

 

The Issuer shall at all time ensure that the Register is available to the Bondholders for inspection, provided that the Bondholders give the Issuer reasonable prior notice in writing.

 

12

 

10.3              Any Bondholder and any Warrant Holder shall be entitled to receive free of charge, upon written request sent to the Issuer, a securities account statements showing evidence of the ownership of the Bonds held by him and one copy of the Agreement.

 

11.                     Transmission and transfer

 

11.1              The Bonds shall not be transferrable by the Subscriber, except (i) with the prior written consent of the Issuer or (ii) to an entity controlled by the Subscriber (within the meaning of control as defined in article L. 233-3 of the French Commercial code) or (iii) as part of a transfer of the Bondholder’s global asset portfolio of securities or of the healthcare branch of such portfolio of securities. Transfers of the Bonds shall be effected by an instrument in writing in the usual common form signed by the transferor and shall be notified to the Issuer at the latest thirty (30) Business Days prior to the transmission or transfer. Such notice shall include the specific identity of the transmittee(s) or transferee(s) and, the identity of the controlling shareholder(s), and a confirmation from the transmittee(s) or transferee(s) of its adhesion to the terms of this Agreement.

 

11.2              Every instrument of transfer must be left at the Issuer’s registered office accompanied by the transfer form of the Bonds to be transferred to prove the title of the transferor or his right to transfer the Bonds and, if the instrument shall be executed by some other person on behalf of the transferor, the authority of that person so to do.

 

11.3              To be effective vis-à-vis the Issuer and third parties, any transfer of Bonds shall be registered in the Register kept by the Issuer and the transferor of any Bonds shall be deemed to be the holder of such Bonds until the name of the transferee is entered into the securities accounts in respect thereof. The Issuer shall, within ten (10) Business Days of receipt of documents reasonably necessary to effect a transfer of the Bonds, enter the name of the transferee in the Register.

 

11.4              No fee may be charged to the Subscriber upon subscription of the Bonds and in connection with the initial registration of the Bonds or other document relating to or affecting the original title to any Bonds.

 

11.5              Any transferee that becomes a Bondholder, by whatever means and for whatever reason, shall have the benefit of, and be subject to, all of the rights and obligations arising under this Agreement as regards Bonds.

 

11.6              The Bonds shall not be offered to the public for subscription or purchase and shall not be capable of being dealt in on any stock exchange and no application shall be made to any stock exchange for permission to deal in or for an official or other quotation for the Bonds.

 

12.                     Procedures for payment

 

Any principal, interest or other moneys repayable or payable hereunder on or in respect of any Bonds may be paid by transfer to the bank account designated in writing by the Subscriber.

 

At the time of Issue, this account shall be:

 

	
Bank Name:
    	
 
    	
SVB
    
	
Account Name:
    	
 
    	
Kreos Capital V (UK) Ltd
    
	
IBAN:
    	
 
    	
 
    
	
SWIFT:
    	
 
    	
 
    

 

13

 

13.                     Rights of single or multiple Bondholders and Warrant Holders

 

13.1              For as long as the Subscriber is single, it shall exercise under its own name, all rights and powers reserved by the French Commercial Code (Code de commerce) to the “Masse” under the meaning of Article L. 228-46 of the French Commercial Code (Code de commerce) and to Bondholder’s meetings notably for events referred to in Article L. 228-65 of the French commercial Code, as regards the holding of Bonds.

 

13.2              All Bonds issued after the first Tranche, if any, shall be assimilated to the Bonds of the first Tranche and the holders of such Bonds shall be regarded as Bondholder(s) within the meaning of this Agreement and the Venture Loan Agreement and shall form part of the same Masse. For the avoidance of doubt, the holder(s) of the Warrants, after they have been detached from the Bonds, shall not form part of the same Masse.

 

13.3              As soon as the Bonds are held by more than one holder, the rights of several Bondholders will be governed, in addition to this Agreement, by the provisions of the French commercial Code (Code de commerce), applicable to the Masse.

 

14.                     Remedies and waivers

 

14.1              No failure, delay or other relaxation or indulgence on the part of the Subscriber to exercise any power, right or remedy shall operate as a waiver thereof nor shall any single or partial exercise or waiver of any power, right or remedy preclude its further exercise or the exercise of any other power, right or remedy.

 

14.2              All rights of the Subscriber contained in this Agreement are in addition to all rights vested or to be vested in it pursuant to the other Issue Documents, common law or statute.

 

14.3              Each Party hereby acknowledges that the provisions of article 1195 of the French Code civil shall not apply to it with respect to its obligations under the Issue Documents and that it shall not be entitled to make any claim under article 1195 of the French Code civil.

 

15.                     Severability

 

15.1              Each of the provisions of this Agreement and any Issue Document is severable and distinct from the others and if at any time one or more of such provisions is or becomes invalid, illegal or unenforceable the validity, legality and enforceability of the remaining provisions hereof shall not in any way be affected or impaired thereby.

 

15.2              In such case, the Issuer shall do its best effort take appropriate actions to replace such provision with an economically equivalent provision which is valid, legal and enforceable, such commitment being, for the avoidance of doubt, a material commitment.

 

16.                     Notices

 

16.1              All notices, demands or other communications under or in connection with this Agreement may be given by letter, facsimile or other comparable means of communication addressed to the person at the address identified with its signature below.

 

	
To Issuer:
    	
 
    	
Biophytis S.A.
    
	
 
    	
 
    	
A l’attention de Monsieur Stanislas Veillet
    
	
 
    	
 
    	
Président Directeur Général
    
	
 
    	
 
    	
and Monsieur Jean-Christophe Montigny
    
	
 
    	
 
    	
Directeur administratif et financier
    
	
 
    	
 
    	
14, avenue de l’Opéra
    
	
 
    	
 
    	
75001 Paris
    

 

14

 

	
 
    	
 
    	
E-mail: stanislas.veillet@biophytis.com and   jc.montigny@biophytis.com
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
With copy (for information purposes) to:
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Monsieur Marc Fredj
    
	
 
    	
 
    	
Avocat associé
    
	
 
    	
 
    	
Reed Smith LLP
    
	
 
    	
 
    	
112, avenue Kléber
    
	
 
    	
 
    	
75116 Paris
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
E-mail: mfredj@reedsmith.com
    
	
 
    	
 
    	
Fax: 01.76.70.41.19
    
	
 
    	
 
    	
 
    
	
To Subscriber:
    	
 
    	
Kreos Capital V (UK) Ltd.
    
	
 
    	
 
    	
To the attention of Mr. Maurizio Petitbon
    
	
 
    	
 
    	
5th Floor, 25-28   Old Burlington Street
    
	
 
    	
 
    	
London W1S 3AN
    
	
 
    	
 
    	
United Kingdom
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Email: maurizio@kreoscapital.com
    
	
 
    	
 
    	
Fax: +44 20 7409 1034
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
With copy (for information purposes) to:
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Monsieur Laurent Cavallier
    
	
 
    	
 
    	
Avocat associé
    
	
 
    	
 
    	
Reinhart Marville Torre
    
	
 
    	
 
    	
58, avenue Kleber
    
	
 
    	
 
    	
75116 Paris
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
E-mail: cavallier@rmt.fr
    
	
 
    	
 
    	
Fax: +33 (0)1 53 96 04 20
    

 

16.2              Any such communication will be deemed to be given as follows:

 

	
(i)
    	
 
    	
if personally delivered, at the time of delivery, as   documented by a receipt;
    
	
 
    	
 
    	
 
    
	
(ii)
    	
 
    	
if by letter, on the date entered by the addressee   on the receipt in the case of delivery by hand or on the date when delivery   is first attempted in the case of a recorded delivery letter with   acknowledgement of receipt; and
    
	
 
    	
 
    	
 
    
	
(iii)
    	
 
    	
if by facsimile transmission or comparable means of   communication during the business hours of the addressee then on the day of   transmission, otherwise on the next following Business Day.
    

 

16.3              In proving such service it shall be sufficient to prove that personal delivery was made or that such letter was properly stamped first class, addressed and delivered to the postal authorities or in the case of facsimile transmission or other comparable means of communication that a confirming hard copy was provided promptly after transmission.

 

15

 

17.                     Law and jurisdiction

 

17.1              This Agreement is governed by and shall be construed in accordance with French law.

 

17.2              Any dispute concerning the validity, interpretation or performance of this Agreement will be submitted to the Tribunal de commerce (commercial court) of Paris.

 

Executed in Paris

in two (2) originals

On September 10th, 2018

 

 

	
/s/ Stanislas Veillet
    	
 
    	
/s/ Maurizio Petitbon
    
	
Biophytis   S.A.
    	
 
    	
Kreos Capital V (UK)   Limited
    
	
Mr. Stanislas   Veillet
    	
 
    	
Mr. Maurizio Petitbon
    

 

16

 

List of Appendixes

 

	
Appendix 2.2 (a)
    	
Template Drawdown   Notice
    
	
 
    	
 
    
	
Appendix 2.2 (b)
    	
Terms and conditions of   the Warrants
    
	
 
    	
 
    
	
Appendix 2.7
    	
Template subscription   form
    
	
 
    	
 
    
	
Appendix 5.1
    	
Amortization and   repayment schedule
    
	
 
    	
 
    
	
Appendix 6.3
    	
Prepayment discount   example
    

 

17Exhibit 10.3

 

PORTIONS OF THIS EXHIBIT IDENTIFIED BY [*****] HAVE BEEN EXCLUDED  FROM THIS EXHIBIT BECAUSE THE EXCLUDED  INFORMATION IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED.

 

Translation for information purposes only

 

 

	
 
    	
 
    	
GOODWILL

PLEDGE AGREEMENT
    	
 
    	
In   agreement with the parties, this agreement has been bound by the ASSEMBLACT   R.C. process, preventing any substitution or addition and is only signed on   the last page
    

 

Between

 

Biophytis S.A.

 

as Pledgor

 

and

 

Kreos Capital V (UK) Ltd.

 

as Beneficiary

 

10 September 2018

 

 

1

 

Table of Contents

 

	
1.
    	
Definitions   and Interpretation
    	
4
    
	
 
    	
 
    	
 
    
	
2.
    	
Pledge
    	
5
    
	
 
    	
 
    	
 
    
	
3.
    	
Designation   of the Pledged Goodwill
    	
5
    
	
 
    	
 
    	
 
    
	
4.
    	
The   declarations, commitments and warranties of the Pledgor
    	
6
    
	
 
    	
 
    	
 
    
	
5.
    	
Execution
    	
8
    
	
 
    	
 
    	
 
    
	
6.
    	
The   allocation of income
    	
9
    
	
 
    	
 
    	
 
    
	
7.
    	
Miscellaneous   provisions
    	
9
    
	
 
    	
 
    	
 
    
	
8.
    	
Powers
    	
9
    
	
 
    	
 
    	
 
    
	
9.
    	
Mandate
    	
10
    
	
 
    	
 
    	
 
    
	
10.
    	
Successors   and beneficiaries
    	
10
    
	
 
    	
 
    	
 
    
	
11.
    	
Charges
    	
10
    
	
 
    	
 
    	
 
    
	
12.
    	
Declaration   — Registration
    	
10
    
	
 
    	
 
    	
 
    
	
13.
    	
Term and   release
    	
11
    
	
 
    	
 
    	
 
    
	
14.
    	
Notices
    	
12
    
	
 
    	
 
    	
 
    
	
15.
    	
The   election of domicile
    	
12
    
	
 
    	
 
    	
 
    
	
16.
    	
Copies -   Language
    	
12
    
	
 
    	
 
    	
 
    
	
17.
    	
Applicable law   and jurisdiction
    	
12
    
	
 
    	
 
    	
 
    
	
Annex 1:
    	
 
    	
13
    
	
 
    	
 
    	
 
    
	
Annex 2:
    	
 
    	
14
    
	
 
    	
 
    	
 
    
	
Annex 3
    	
 
    	
15
    
	
 
    	
 
    	
 
    
	
Annex 4
    	
 
    	
18
    

 

2

 

Goodwill Pledge Agreement

 

This pledge agreement (hereinafter referred to as the “Agreement”) is concluded on 10 September 2018, between the undersigned:

 

1,                         Biophytis S.A., a public limited company with capital of 2,692,682.60 EUR, whose registered office is located at 14, avenue de l’Opéra - 75001 Paris, identified under the unique number 492 002 225 of the RCS [Trade and Companies Register] of Paris, whose securities are listed on the organised multilateral trading facility Euronext Growth under ISIN number FR0012816825, represented by Mr Stanislas Veillet as Chairman and Chief Executive Officer;

 

(Hereinafter referred to as the “Pledgor”)

 

ON THE ONE HAND,

 

AND

 

2.                         Kreos Capital V (UK) Limited, private limited company under English law, whose registered office is located at 5th Floor, 25-28 Old Burlington Street, London W1S 3AN, United Kingdom, registered with the Company Register of England and Wales under number 09728300, acting in the capacity as representative of the group being formed of the holders of the bonds to be issued under the Issuing Agreement, represented by Mr Maurizio Petitbon, in his capacity as Director, duly authorised for the purposes hereof;

 

(Hereinafter referred to as the “Beneficiary”)

 

ON THE OTHER HAND

 

The Pledgor and the Beneficiary are hereinafter individually referred to as a “Party” and collectively as the “Parties”.

 

Recitals

 

(A)                  The Pledgor is a public limited company under French law founded in 2006 in order to develop new classes of drugs for degenerative diseases associated with ageing, and in particular with sarcopenia (the loss of muscle functionality) and macular degeneration related to ageing.

 

(B)                  The Beneficiary has agreed to make available to the Pledgor the maximum amount in principal of ten million Euros (10,000,000 EUR) by virtue of an issue agreement concluded on 10 September 2018 between the Pledgor, as issuer (Issuer), and the Beneficiary, in the capacity of subscribers (Subscriber), named the Bonds Issue Agreement (hereinafter referred to as the “Issue Agreement”), itself concluded in application of a framework agreement entitled Venture Loan Agreement concluded on 10 September 2018 between the Parties (hereinafter referred to as the “Framework Agreement”).

 

(C)                  In accordance with the provisions of the Issue Agreement and the Framework Agreement, as collateral for the proper performance of the Secured Obligations (as defined below), the Pledgor constituted a pledge over the Goodwill (as defined in Article 2 (a) below), in accordance with the terms and conditions of this Agreement.

 

3

 

Agreements

 

1.                                      Definitions and Interpretation

 

1.1                               The terms and expressions used in this Agreement shall have, unless the context does not permit it, the following meanings:

 

	
Agreement
    	
 
    	
means this agreement and its Appendices,   in their initial version and any version subsequently amended, if applicable;
    
	
 
    	
 
    	
 
    
	
Event of Default
    	
 
    	
refers to any of the events mentioned in   Article 9 (Events of Default) of the   Issue Agreement;
    
	
 
    	
 
    	
 
    
	
Event of Implementation
    	
 
    	
means (i) the occurrence of a   failure to pay by the Pledgor under the Issue Agreement, under the conditions   of paragraph 9.1 of the Issue Agreement or (ii) the sending of a   notification of immediate repayment obligations to the Pledgor in the terms   of paragraph 9.14 Issue Agreement;
    
	
 
    	
 
    	
 
    
	
Issue Documents
    	
 
    	
means the Issue Agreement, the Framework   Agreement, the terms and conditions of the share subscription warrants (Terms and Conditions of the Warrants), all securities   documents (Security Documents), and any other   document referred to as such in writing by the Parties;
    
	
 
    	
 
    	
 
    
	
Licence
    	
 
    	
means any licence agreement of all or   part of the industrial property rights granted, as described in   Article 3.2 of the Agreement, stipulating an initial immediate payment   at least equal to [****];
    
	
 
    	
 
    	
 
    
	
Maturity Date
    	
 
    	
refers to the date of full payment by   the Pledgor of all of the Secured Obligations;
    
	
 
    	
 
    	
 
    
	
Pledge
    	
 
    	
refers to the pledge of the Pledged   Goodwill, as defined in Article 2 below;
    
	
 
    	
 
    	
 
    
	
Secured Obligations
    	
 
    	
refers to the payment and repayment   obligations, either present or future, in principal, interests, late   interest, fees, commissions, accessories or any other sum whatsoever   (including in respect of default, cancellation, the termination or resolution   of any Security Document (Security Document),   borne by the Debtor as regards the Beneficiary under the Issue Documents;
    
	
 
    	
 
    	
 
    
	
Warranty Period
    	
 
    	
refers to the period beginning on the   date of this Agreement and ending on the Maturity Date (inclusive).
    

 

1.2                               In this Agreement, except as expressly defined otherwise, capitalised terms not otherwise defined in this Agreement shall have the meaning specified in the Issue Agreement and the Framework Agreement.

 

4

 

2.                                      Pledge

 

2.1                               In guarantee of the payment and fulfilment of all of the Secured Obligations, and in accordance with the provisions of Articles L. 142-1 et seq. of the Commercial Code and Articles 2355 et seq. of the Civil Code (hereinafter, the “Law”), the Pledgor hereby constitutes in favour of the Beneficiary a pledge on its goodwill as designated in Article 3 (hereinafter, the “Pledged Goodwill”) of which it is the owner.

 

2.2                               The pledge constituted by this Agreement (hereinafter, the “Pledge”) remains in effect until the expiry of the Warranty Period.

 

3.                                      Designation of the Pledged Goodwill

 

3.1                               In accordance with Article L. 142-2 paragraph 4 of the Commercial Code, it is stipulated that the Pledged Goodwill is operated at the following premises: 14, avenue de l’Opéra - 75001 Paris, France (hereinafter “the Main Establishment”), it being specified that the Pledged Goodwill is more specifically operated on the premises of the Sorbonne University at building A4.4 place Jussieu, 75005 Paris.

 

3.2                               The Pledged Goodwill includes the following assets and rights:

 

(i)                                     The customers and the customer flow;

 

(ii)                                  the following industrial property rights:

 

(a)                                 Each:

 

1.                                      of the national patent as registered with the National Register of Patents of the INPI [Institut national de la propriété industrielle (National Institute of Industrial Property)] (hereinafter, the “NRP”); and

 

2.                                      European Patents from the European Patent Office (hereinafter, the “EPO”),

 

3.                                      the brands associated with these patents, namely Sarconeos (WIPO [World Intellectual Property Organisation] trademark 1345067, as regards the European Union, and INPI trademark 4252449) and Macuneos (WIPO trademark 1343148 as regards the European Union, and INPI trademark 4252454),

 

4.                                      If necessary, domain names corresponding to said trademarks,

 

of which a list, as of the date of this Agreement, is included in Appendix 1, as well as

 

(b)                                 Subject to:

 

·                                          the occurrence of a Event of Default notified to the Pledgor, or, and without prejudice to any other collateral of which the Beneficiary may request implementation, as well as

 

·                                          in the event that the Beneficiary grants a release under a licence providing for an immediate initial payment of less than [****],

 

each of the:

 

·                                          patents granted within the framework of the Patent Cooperation Treaty including France with the World Intellectual Property Organisation;

 

·                                          such national trademarks that are registered with the National Institute of Industrial Property (hereinafter, “INPI”) and Community trademarks as registered in France with the European Union Intellectual Property Office (hereinafter, “EUIPO”), provided that these trademarks are

 

5

 

associated with a product for which manufacture is based on a compound, patent, or patent family within the pledge’s scope;

 

·                                          if necessary, domain names corresponding to said trademarks,

 

of which a list, as of the date of this Agreement, is included in Appendix 2, and

 

(c)                                  to the extent determined as part of the annual review specified in paragraph 5.3 of the Framework Agreement, any industrial property rights of the same nature as those referred to in paragraph (a) above, as well as (subject to the reservations stipulated in this paragraph) in paragraph (b) above, of which the Pledgor or any Subsidiary would in any way become the owner after the date of this Agreement, in accordance with and subject to the provisions of article 2355 of the Civil Code, including the rights that are currently the subject of an application and/or filing still being processed as of the date of this Agreement.

 

(iii)                               subject to the law and this Agreement, once they have been obtained, each of the marketing authorisations in jurisdictions covered by the patents falling within the scope of the Pledge, and, as strictly necessary, for the marketing in these jurisdictions of products covered by the patents falling within the scope of the Pledge, the know-how (including any information or material, patented or not, patentable or not, including, but not limited to, any document that is mandatory under the regulations of those jurisdictions, administration records related to manufacturing up until the batch release phase, inventions, data, formulae, methodology, specifications, manufacturing procedures, experiences and tests, all information (in particular regulatory, administrative, medical, technical and commercial), including any document that is mandatory under the regulations of those jurisdictions enabling the exploitation of the products covered by these marketing authorisations.

 

(iv)                              The rights of the Beneficiary extend to all insurance compensation and other compensation that would be due in respect of a requisition or a dispossession and all other damages or payments may be substituted for any part of the constituent elements of the Pledged Goodwill.

 

As an additional security, the Pledgor undertakes to inform the Beneficiary in order to allow it to carry out, at the expense of the Pledgor and provided that these fees are reasonable, all the formalities that may be reasonably necessary or useful to make the pledge from these indemnities and revenue enforceable against third parties.

 

(v)                                 In accordance with Article L.121-13 of the French Insurance Code, the Beneficiary may, upon notification by the latter to the Pledgor of a Event of Implementation, notify this Pledge to the insurance companies mandated to insure the Pledged Goodwill, at the expense of the Pledgor, provided that these fees are reasonable.

 

3.3                               Furthermore, the Beneficiary shall have a right of access without restrictions, to any medical literature relative to products, communications, clinical and preclinical results, test procedures, medical information, data security and pharmacovigilance, documentation concerning the manufacture, batch records, stability data that may be necessary in connection with the exploitation of the patents falling within the scope of the Pledge.

 

4.                                      The declarations, commitments and warranties of the Pledgor

 

4.1                               Without prejudice to the declarations and warranties subscribed under the terms of the Framework Agreement, the Pledgor shall declare and warrant to the Beneficiary on the date of this Agreement that:

 

6

 

(a)                                 no authorisation, approval, consent, licence, notification or other request of a public entity or corporate bodies of the Pledgor is required for the validity, performance or enforceability of this Agreement, with the exception of any authorisation which has been duly obtained beforehand and whose justification has been provided to the Beneficiary,

 

(b)                                 the present Agreement and the commitments contained therein:

 

(i)                                     constitute valid obligations, binding the Pledgor in accordance with their terms, enforceable against the Pledgor, and

 

(ii)                                  create a first rank pledge on the Pledged Goodwill.

 

(c)                                  Insofar as that could have a material adverse effect (Material Adverse Effect as defined in this Issue Agreement) as to the ability of the Debtor to perform its obligations under this Agreement, no failure to meet its obligations has occurred under any contract or agreement to which the Debtor is a party;

 

(d)                                 there is, to the knowledge of the Debtor, no ongoing action, suit or jurisdictional proceeding or before any administrative authority whatsoever that may have a material adverse effect (Material Adverse Effect, as defined in this Issue Agreement) on the validity of the obligations, as stipulated in the Agreement or the ability of the Debtor to perform such obligations;

 

(e)                                  the Pledged Goodwill is free of any guarantees or other sureties of any nature whatsoever, and none of the assets that are part of the Goodwill is encumbered, at the date of this Agreement, by a security, lien or other right of any nature whatsoever, in favour of a third party. A statement of pledges and liens on the Pledged Goodwill as of the date of 6 September 2018 can be found in Appendix 3 to this Agreement.

 

4.2                               The Pledgor undertakes, for the entire Warranty Period, to:

 

(a)                                 comply strictly with the provisions of Article 8 (Undertakings) of the Issue Agreement as well as article 5 (Commitments) of the Framework Agreement;

 

(b)                                 communicate to the Beneficiary any significant information relating to the Pledged Goodwill and in particular any dispute relating thereto;

 

(c)                                  not to sell, transfer or otherwise dispose of the Pledged Goodwill or any of its rights under the Pledged Goodwill without the prior written consent of the Beneficiary;

 

(d)                                 not to grant any security whatsoever on the Pledged Goodwill or any of its rights under the Pledged Goodwill without the prior written consent of the Beneficiary or any other related right, it being specified, however, that the Pledgor is expressly authorised to grant any licence on one of the components of the Pledged Goodwill, provided that they do not contain provisions that could prevent the implementation of the Pledge, as well as continue the performance of licences granted prior to the conclusion of this Agreement;

 

(e)                                  not to grant or allow the continuation of any surety on all or part of the Pledged Goodwill or of any right of the Pledged Goodwill in favour of a third party without having expressly given the prior approval of the Beneficiary;

 

(f)                                   to sign any instrument or document and to carry out all other measures and formalities reasonably required by the Beneficiary to render enforceable and ensure the effectiveness of the Pledge or take the forced execution of the Pledge in accordance with this Agreement;

 

(g)                                  to make its best efforts to preserve the current value of the Pledged Goodwill by continuing, to the extent possible:

 

(i)            to pursue any commercially profitable activity;

 

(ii)           to maintain the Pledged Goodwill well-stocked and maintain the equipment and tools, and

 

7

 

(iii)                               to take any necessary measures to obtain, protect, control, maintain, update and keep its marketing authorisations using patents falling within the scope of the Pledge;

 

(h)                                 to establish a pledge that is compliant, essentially, under the terms of this Agreement, in favour of the Beneficiary to ensure the Secured Obligations, on the activity of any branch of the Pledged Goodwill that the Pledgor may operate after the date of this Agreement;

 

(i)                                     in the Event of a change in the location of the Goodwill by the Pledgor, anywhere and under any circumstances, the Pledgor undertakes to carry out, at its own expense, all formalities that the Beneficiary may reasonably require and which are necessary to enforce or protect all rights, powers, capacities and faculties of which the Beneficiary benefits under this Agreement. The Pledgor specifically undertakes to inform the Beneficiary, at least fifteen (15) days in advance, of its intention to move the Pledged Goodwill and the new location to where it intends to move it, in accordance with Article L, 143-1 of the French Commercial Code;

 

(j)                                    not to grant a leasing-management on the Pledged Goodwill until the end of the Warranty Period.

 

4.3                               The Debtor agrees to apply the commitments undertaken under Article 5 (Commitments} of the Framework Agreement, and undertakes to apply them, mutatis mutandis and to the extent possible, to the Pledged Goodwill.

 

4.4                               The Pledgor agrees to refrain, in order to release its commitment, from invoking any change in the legal form of the Beneficiary even if it entails the creation of a new legal personality.

 

4.5                               The Pledgor will not be released due to:

 

(i)                                     modifications (occurring one or more times but provided they do not lead to novation);

 

(ii)                                  the addition or removal of new securities, new creditors or new debtors;

 

(iii)                               the extension of maturity dates;

 

Or any other event affecting in any manner whatsoever the stipulations of the Issue Agreement and the Framework Agreement,

 

5.                                      Execution

 

5.1                               In the event of the occurrence of an Event of Implementation and failing the processing of an Event of Implementation under the conditions stipulated in the Issue Agreement, the Beneficiary may, at any time, exercise all rights, acts and privileges granted to the Beneficiary by the Law on the Pledged Goodwill.

 

8

 

5.2                               The Pledgor hereby undertakes to make its best efforts to provide to the Beneficiary with all the necessary assistance to execute this Pledge, to sign and make enforceable any deed or document and to undertake any formality necessary for this purpose, and indemnify the Beneficiary for any losses, expenses and charges of this Agreement or the said execution, in accordance with Article 12 below. The Pledgor undertakes in particular to carry out, if applicable, all necessary formalities with the Agence Nationale de Sécurité du Médicament [French National Agency for Medicines Safety] and with any regulatory authority concerned in order to facilitate the transfer of the marketing authorisations obtained.

 

6.                                      The allocation of income

 

Any amounts collected from the Pledgor by the Beneficiary under this Agreement are allocated by the Beneficiary to the payment of the Secured Obligations, in accordance with the terms of the Issue Agreement. Any amount which may be received from the Beneficiary under the terms of this Agreement, beyond the Secured Obligations, shall be reimbursed without delay by the Beneficiary to the Pledgor, subject to any contrary provisions set out in this Agreement.

 

7.                                      Miscellaneous provisions

 

7.1                               The Beneficiary is liable for any loss due to the exercise or any failure or omission to exercise its rights under this Agreement. The Pledgor is solely responsible for its own contracts, commitments, acts, omissions, defaults and losses and liabilities incurred by it and the Beneficiary does not assume any liability in this regard (with respect to the Pledgor or any other person) for any reason whatsoever.

 

7.2                               No failure to exercise or delay in exercising, by the Beneficiary, any right or remedy under this Agreement shall be construed as constituting a waiver to said right or remedy. No single or partial exercise of any right or remedy prevents any other exercise thereof or the exercise of any other right or remedy in the future. The Beneficiary does not assume any responsibility towards the Pledgor or its legal successors, individually or generally, due to the delay in exercising or failure to exercise of rights and prerogatives granted to the Beneficiary under this Agreement,

 

The rights and remedies provided for in this Agreement are cumulative and exclusive of any right or remedy provided by law and may only be waived in writing and in an express manner.

 

7.3                               The Pledge is in addition to any security or any bond held, if applicable, by the Beneficiary under the terms of the Secured Obligations or any of them and is under no circumstances affected by any other security mentioned above and exists without prejudice to it.

 

7.4                               In the event that one or more of the provisions of this Agreement will be deemed to be illegal, invalid or unenforceable, this Agreement shall be construed as if it does not contain such provision and the nullity of said provision shall not affect the validity or the execution of any other provision of this Agreement, which shall remain fully applicable.

 

7.5                               The parties to the Agreement acknowledge that the sole purpose of this Agreement is to create this Pledge in favour of the Beneficiary and is not intended to change the rights and obligations set out in the Issue Agreement.

 

9

 

8.                                      Powers

 

The Beneficiary or any person designated by the latter may confer any power with or without the right of substitution, to any person of its choice, to proceed with any registration or other formalities, as well as implementing any measures for the executions of the rights arising from this Pledge of the Pledged Goodwill.

 

9.                                      Mandate

 

9.1                               The Pledgor here by appoints, in order to ensure the full performance of its obligations under this deed, the Beneficiary and any person appointed by the Beneficiary under the terms of this deed, as representative acting jointly and severally and in its name and on its behalf, to sign and carry out all formalities and steps which the Pledgor is obliged to carry out under this Agreement, which it will do in accordance with the commitments and provisions contained in this Agreement.

 

9.2                               It is specified that before carrying out such actions by virtue of the mandate provided for in this article 10, the Beneficiary must inform the Pledgor, which may oppose the performance of such actions for valid reasons.

 

10.                               Successors and beneficiaries

 

10.1                        All rights, privileges, use and options granted to the Beneficiary under this Agreement will benefit its assignees, successors and/or beneficiaries and all terms, conditions, declarations, guarantees, promises and commitments contained in this Agreement bind the Pledgor and its assignees, successors and/or beneficiaries.

 

10.2                        It is expressly agreed that the Pledgor may not assign or transfer to any third parties, through novation or in any manner whatsoever, its rights and obligations as arising out of this Agreement without the prior written consent of the Beneficiary, and that the Beneficiary is authorised to sell and delegate its rights and obligations arising from this Agreement to any third party.

 

10.3                        The Parties agree that in the event of the assignment or transfer by the Beneficiary of all or some of its rights and obligations under the Issue Documents, to any person (hereinafter referred to as the “Assignee”) through novation or in any other manner, the Pledgor and the Beneficiary agree that the benefit of the security created by the Agreement will be assigned and maintained for the benefit of the Assignee.

 

11.                               Charges

 

Subject to the stipulations of the Issue Agreement and the Framework Agreement on the cap on the assumption by the Constituent of reasonable costs and expenses incurred (in accordance with the provisions of article 9 of the Framework Agreement) and on the exclusion of the indirect damage which they provide for, the Pledgor undertakes, if necessary, at the request of the Beneficiary, to indemnify the Beneficiary for all reasonable expenses and costs, including legal fees and expenses, and all charges, taxes, fees or registration fees, associated (i) with the performance of this Agreement, (ii) for the execution of the formalities related to the constitution, renewal and release of the Pledge, and (iii) with the protection, preservation or exercise of the rights of the Beneficiary in terms of the Pledge.

 

10

 

12.                               Declaration — Registration

 

12.1                        In accordance with the provisions of French law currently in force, this Agreement must be registered with the Tax Revenue.

 

12.2                        Pursuant to Article L. 142-3 of the French Commercial Code, within thirty (30) days of the signature of this Agreement, a first-rank entry of the Pledge of the Pledged Goodwill will be taken at the behest of the Beneficiary before the Clerk of the Commercial Court of Paris for a sum, in principal, of [****].

 

12.3                        This Agreement and, if applicable, any intellectual property addition, will be the subject of a registration with any appropriate industrial property rights register in accordance with the legal and regulatory provisions applicable to each of the industrial property rights granted and at the latest within fifteen (15) days following the modificative registration of the Pledge of the Pledged Goodwill with the Clerk of the Commercial Court of Paris, in accordance with the provisions of Article L. 143-17 of the French Commercial Code.

 

12.4                        The Debtor undertakes to formalise the addition, pursuant to the provisions of paragraph 3.2 of this Agreement, of any new industrial property rights falling within the scope of the Pledge, by the signature of a confirmatory deed in accordance with the template which can be found in Appendix 4.

 

12.5                        The holder of an original of this Agreement is hereby granted all the powers necessary for completing the formalities of the registration and enrolment of the Pledge of the Pledged Goodwill.

 

13.                               Term and release

 

13.1                        This Agreement shall come into force on the date of its signature by the Parties and will continue to produce all its effects throughout the Warranty Period, it being indicated that the Pledge is registered with the Clerk of the Commercial Court of Paris for the term provided for by the provisions of Article L. 143-19 of the French Commercial Code.

 

13.2                        The Pledgor undertakes to renew the registration of this Pledge (for a redefined amount - deducting the repayments made) if, at the end of the registration provided for in the article above, any one of the Secured Obligations remains unpaid, is not executed or paid and the Pledgor agrees, in the common interests of the parties, to renew this registration and give the Beneficiary an irrevocable mandate and power to sign any deeds and documents and carry out all the formalities required for this purpose.

 

13.3                        At the end of the Warranty Period, and upon receipt of a written request by the Pledgor requesting a written confirmation that the Warranty Period has ended, the Beneficiary shall sign, at the expense of the Pledgor, an act of release thus releasing the Pledgor from all its obligations and liabilities arising out of this Agreement.

 

13.4                        Notwithstanding the foregoing, in the event that the Pledgor may conclude a Licence with a business partner, the Beneficiary undertakes, provided that no Event of Implementation has occurred and that no Event of Default is in progress, to immediately grant an early release of the Pledge on the pledged industrial property rights subject to the Licence.

 

This release shall occur immediately upon the presentation of a term sheet signed by both parties providing for the initial payment mentioned above.

 

In the case that the Licence is not entered into force in accordance with the said term sheet within a period of 90 days from the date of such release, the Pledgor undertakes to immediately do everything necessary and to sign any documents necessary for the recovery of the Pledge in accordance with its terms and conditions prior to the release. The Pledgor undertakes not to grant any pledge or other licence on the industrial property rights

 

11

 

during this period. The same will apply in the event of the termination or cancellation of the Licence, for any reason whatsoever.

 

14.                               Notices

 

All communications to be made pursuant to this Agreement must be carried out in conformity with Article 9 (Notices) of the Framework Agreement, as if said article was included in this Agreement, mutatis mutandis.

 

15.                               The election of domicile

 

For the purposes of the registration of the pledge on the Pledged Goodwill in the Trade and Companies Register, the Beneficiary has elected domicile at the registered office of the Pledgor.

 

16.                               Copies - Language

 

This Agreement is signed in 8 (eight) original copies, in French, all equally valid, 6 (six) of which are for registration purposes or for registration in the first rank of pledge on the Pledged Goodwill.

 

17.                               Applicable law and jurisdiction

 

17.1                        This Agreement and each document attached thereto are governed by French law and interpreted

 

in accordance with said law.

 

17.2                        The Parties hereby and irrevocably acknowledge the exclusive jurisdiction of the competent courts of Paris, as regards any action or proceeding arising out of this Agreement or relating to it or to all corresponding documents or deeds concluded in accordance with this Agreement.

 

Drawn up in Paris

 

On 10 September 2018

 

 

	
/s/ Stanislas Veillet
    	
 
    	
/s/ Maurizio Petitbon
    
	
Biophytis S.A.
    	
 
    	
Kreos Capital V (UK) Ltd.
    
	
Mr Stanislas Veillet
    	
 
    	
Mr Maurizio Petitbon
    
	
Chairman and Chief Executive Officer
    	
 
    	
Director
    

 

12

 

Annex 1:

 

The identification of the industrial property rights granted at the date of this Agreement

 

13

 

Annex 2:

 

The identification of the industrial property rights granted subject to the provisions of paragraph 3.2 (iii) (b)

 

14

 

Annex 3

 

The statement of pledges and liens

 

15

 

The statement of debt > Debtors

 

[stamp: Print]

 

DEBTORS

 

SA BIOPHYTIS

492 002 225

R.C.S. PARIS

 

Address: 14 AV DE L’OPERA 75001 PARIS

Clerk of the Commercial Court of PARIS

 

In the event of a reserve, please view the detail of the registrations below.

 

RECEIVED BY MAIL

 

TO RECEIVE A STATEMENT OF DEBT ISSUED AND CERTIFIED BY THE COURT CLERK

 

	
REGISTRATION TYPE
    	
 
    	
NUMBER OF
   REGISTRATIONS
    	
 
    	
FILE UPDATED
   ON
    	
 
    	
SUMS KEPT
    
	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    
	
Privileges of social security and   supplementary schemes
    	
 
    	
None
    	
 
    	
06/09/2018
    	
 
    	
—
    
	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    
	
The pledging of goodwill and artisanal   business  (conventional   and judicial)
    	
 
    	
None
    	
 
    	
06/09/2018
    	
 
    	
—
    
	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    
	
Public Treasury Privileges
    	
 
    	
None
    	
 
    	
06/09/2018
    	
 
    	
—
    
	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    
	
Protests
    	
 
    	
None
    	
 
    	
06/09/2018
    	
 
    	
—
    
	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    
	
The privileges of the seller of goodwill   and resolutive action
    	
 
    	
None
    	
 
    	
06/09/2018
    	
 
    	
—
    
	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    
	
The pledging of tools, material and   equipment
    	
 
    	
None
    	
 
    	
06/09/2018
    	
 
    	
—
    
	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    
	
The statement of debts
    	
 
    	
None
    	
 
    	
06/09/2018
    	
 
    	
—
    

 

16

 

	
Movable property leasing transactions
    	
 
    	
None
    	
 
    	
06/09/2018
    	
 
    	
—
    
	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    
	
The publishing of lease agreements
    	
 
    	
None
    	
 
    	
06/09/2018
    	
 
    	
—
    
	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    
	
The publishing of ownership reservation   clauses
    	
 
    	
None
    	
 
    	
06/09/2018-
    	
 
    	
—
    
	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    
	
Inventory pledge
    	
 
    	
None
    	
 
    	
08/09/2018-
    	
 
    	
—
    
	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    
	
Warrants
    	
 
    	
None
    	
 
    	
08/09/2018
    	
 
    	
—
    
	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    
	
Loans and deadlines
    	
 
    	
None
    	
 
    	
06/09/2018
    	
 
    	
—
    
	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    
	
Inalienable assets
    	
 
    	
None
    	
 
    	
06/09/2018
    	
 
    	
—
    

 

17

 

Annex 4

 

Notice template

 

18

 

[On the letterhead of the Pledgor]

 

From: [•] in his/her capacity of Debtor

 

To: [•] in his/her capacity of Beneficiary

 

Date: [•]

 

The pledge by [•] Industrial Property Rights - The confirmation of the Pledge

 

Dear Sir/Dear Madam,

 

(a)                              We refer to a goodwill pledge agreement dated [•] 2018 concluded between Biophytis S, A. as Debtor and the Beneficiary under the Issue Agreement, a copy of which is attached hereto as Appendix 1 (the “Pledge Deed”).

 

(b)                              Terms and expressions used and not defined in this Confirmation shall have the meanings ascribed to them in the Pledge Deed.

 

(c)          By this Confirmation, the Pledgor:

 

(i)                                 confirms that the industrial property rights described in Appendix 2 to this Confirmation, which the Debtor owns, are included in the basis of the Pledge established under the terms of the Pledge Deed, as a security and guarantee for the proper execution and the full payment of the rights granted in favour of the Beneficiary;

 

(ii)                              takes note that the provisions of the Pledge Deed apply to the industrial property rights set out in sub-paragraph (i) above, which shall be deemed to become the Pledged Industrial Property Rights as of the date on which the Debtor has become the owner.

 

	
[•]
    	
 
    
	
Debtor
    	
 
    
	
 
    	
 
    
	
For: [•]
    	
 
    

 

Appendix 1 - A copy of the Pledge Deed

 

Appendix 2 - A description of the Pledged new Industrial Property Rights

 

19

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00319-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00319-of-00352.parquet"}]]