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                                                                    EXHIBIT 10.2

                    FIRST AMENDMENT TO STOCKHOLDER AGREEMENT

         This First Amendment (the "First Amendment") to the Stockholder
Agreement dated July 25, 2000 ("Stockholder Agreement"), by and among Genencor
International, Inc. ("Company"), Eastman Chemical Company ("Eastman"), and
Danisco A/S ("Danisco") is dated the 16th day of February, 2001 and the
provisions of this First Amendment shall be effective as of the date set forth
herein.

                                    RECITALS

         Eastman and Danisco may desire to expand their rights to manage certain
assets, including their rights in the Company, by transfer of those shares to a
wholly owned subsidiary of their respective companies, and without otherwise
disturbing the rights of the Parties in the Stockholder Agreement. Therefore,
the Parties have agreed to enter into this First Amendment to achieve the
foregoing objectives.

                                    AGREEMENT

         NOW THEREFORE, in consideration of the premises and covenants set forth
in this First Amendment and the Stockholder Agreement, the receipt and
sufficiency of which are hereby acknowledged, the Parties hereto agree to amend
the Stockholder Agreement as follows:

1.       The text of paragraph 16.2 of the Stockholder Agreement dated July
         25th of 2000 shall be retained in its entirety as 16.2(a).

2.       In addition to the renumbering of paragraph 16.2, the Parties agree to
         add the following paragraph:

         16.2(b) Notwithstanding other provisions of this agreement, both
         Eastman and Danisco may assign the Common Stock, as well as any
         Preferred Stock they may hold in Company, to any wholly owned
         subsidiary on the following terms: (i) the assignor agrees to
         unconditionally guarantee the full performance by and remain ultimately
         liable for compliance by any such assignee subsidiary with the terms
         hereof, as well as all requirements concerning any exemptions, taxation
         and other obligations related to the transfer; (ii) the assignor
         advises the other parties of its intent in advance and receives the
         written consent of each the other two parties, which consent shall not
         be unreasonably withheld; and (iii) the assignee agrees in writing to
         succeed to all rights and obligations of the assignor and to be legally
         bound and abide by all terms and conditions of the Stockholder
         Agreement (as amended from time to time).

3.       Except as expressly amended hereby, the provisions of the Stockholder
         Agreement remain unchanged and in full force and effect and this First
         Amendment does not and shall not be deemed to waive, modify or amend
         any other provision or terms of the Stockholder Agreement.

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         IN WITNESS WHEREOF, the Parties' authorized representatives have
executed this First Amendment as of the day and year first above written.

GENENCOR INTERNATIONAL, INC.

By: /s/ Stuart L. Melton
    ----------------------

Its: Senior Vice President
     ---------------------

EASTMAN CHEMICAL COMPANY                DANISCO A/S
                                        (On behalf of itself and its affiliates)

By: /s/ James P. Rogers                 By: /s/ Alf Duch-Pedersen
    ----------------------                  --------------------------------

Its: SVP & CFO                          Its: CEO
     ---------------------                   -------------------------------

                                        By:  /s/ Soren Bjerre-Nielsen
                                             -------------------------------
                                        ITS: CFO
                                             -------------------------------<PAGE>

                                                                    EXHIBIT 10.3

                   SECOND AMENDMENT TO STOCKHOLDER AGREEMENT

         This Second Amendment (the "Second Amendment") to the Stockholder
Agreement dated July 25, 2000 (together with the First Amendment thereto, the
"Stockholder Agreement"), by and among Genencor International, Inc. ("Company"),
Eastman Chemical Company (together with its applicable affiliates "Eastman"),
and Danisco A/S (together with its applicable affiliates "Danisco") is dated the
15th day of November, 2002 and the provisions of this Second Amendment shall be
effective as of the date set forth herein.

                                    RECITALS

         The Parties may desire to expand the total members of directors on the
Board of Directors of the Company without otherwise disturbing the rights of the
Parties currently enjoyed under the Stockholder Agreement. Therefore, the
Parties have agreed to enter into this Second Amendment to achieve the foregoing
objectives.

                                   AGREEMENT

         NOW THEREFORE, in consideration of the premises and covenants set forth
in this Second Amendment and the Stockholder Agreement, the receipt and
sufficiency of which are hereby acknowledged, the Parties hereto agree to amend
the Stockholder Agreement as follows:

1.       The text of Sections 4.1 and 4.3 of the Stockholder Agreement shall be
         deleted in their entirety and replaced by the following text:

                  4.1      Board Composition. The Stockholders and the Company
                           shall take all actions necessary to cause the Board
                           of Directors to be comprised of eleven (11) members,
                           three of whom shall be designees of Eastman (the
                           "Eastman Designees"), three of whom shall be
                           designees of Danisco (the "Danisco Designees," and
                           together with the Eastman Designees, the "Stockholder
                           Designees"), one of whom shall be the Chief Executive
                           Officer of the Company (the "CEO"), one of whom shall
                           be the last persons who are not otherwise affiliates
                           (as defined under the Securities Act and the
                           regulations thereunder) of the Company, Eastman or
                           Danisco (the "Independent Directors").

                  4.3      Voting and Other Actions. The Company and the
                           Stockholder agree to take such actions as are
                           necessary to effectuate the provisions of Sections
                           4.1 and 4.2 both with respect to the time period
                           specified in the first sentence of Section 4.1 and
                           all subsequent elections and appointments of members
                           of the Board. Without limiting the foregoing, the
                           authorized number of members of the Board of
                           Directors shall be no greater than 11 without a
                           further amendment of this agreement in accordance
                           with the provisions of this Agreement. In addition
                           the Company and Stockholders shall also take such
                           other

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                           action as is necessary to ensure that the composition
                           of the Board of Directors is in compliance with the
                           requirements of the Nasdaq National Market.

2.       Except as expressly amended hereby, the provisions of the Stockholder
         Agreement remain unchanged and in full force and effect and this Second
         Amendment does not and shall not be deemed to waive, modify or amend
         any other provision or terms of the Stockholder Agreement.

         IN WITNESS WHEREOF, the Parties' authorized representatives have
executed this Second Amendment as of the day and year first above written.

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<CAPTION>
<S>                                                           <C>
GENENCOR INTERNATIONAL, INC.

By: /s/ Stuart L. Melton
    --------------------------

Its: Senior Vice President
     -------------------------

EASTMAN CHEMICAL COMPANY                                         DANISCO A/S
(On behalf of itself                                             (On behalf of itself and its affiliates)
and its affiliates)

By: /s/ James P. Rogers                                          By: /s/ Alf Duch-Pedersen     /s/ Soren Bjerre-Nielsen
    --------------------------                                       --------------------------------------------------

Its: Chief Financial Officer                                     Its: CEO                      CEO
     -------------------------                                       --------------------------------------------------
</TABLE><PAGE>

                                                                   EXHIBIT 10.10

                            FIRST AMENDMENT TO LEASE

         THIS FIRST AMENDMENT TO LEASE is made as of this 30th day of November,
2001 by and between EASTMAN KODAK COMPANY, a New Jersey corporation having an
office at 343 State Street, Rochester, New York 14650 (hereinafter referred to
as "Landlord") and GENENCOR INTERNATIONAL, INC., a Delaware corporation having
an office at 1700 Lexington Avenue, Rochester, New York 14606 (hereinafter
referred to as "Tenant") and amends that certain Lease dated as of August 28,
1991 (the "Lease") by and between Landlord and Tenant.

                                  WITNESSETH:

         WHEREAS, Landlord and Tenant now desire to modify the Lease with
respect to the providing of certain services from Landlord to Tenant and the
payment of certain sums from Tenant to Landlord; and

         WHEREAS, capitalized terms used but not otherwise described herein
shall have the meanings otherwise ascribed to them in the Lease.

         NOW, THEREFORE, in consideration of the foregoing premises and other
good and valuable consideration, the receipt and sufficiency of which are hereby
acknowledged, the parties agree as follows:

                  1.    TERMINATION OF CERTAIN SERVICES BY LANDLORD. Effective
as of September 1, 2001, Landlord and Tenant agree that Landlord will no longer
provide snowplowing and landscaping services to the Premises at the referenced
location. From and after September 1, 2001, Tenant shall procure, at its sole
cost and expense, snowplowing and landscaping services as reasonably necessary
to keep the Premises (and the land included therein) in good order and
condition.

                  2.    PAYMENT FOR SUCH SERVICES. From and after September 1,
2001, Landlord shall no longer charge Tenant for the costs of snowplowing and
landscaping services pursuant to the provisions of Paragraph 7 of the Lease.

                  3.    RATIFICATION. Except as expressly modified herein, the
parties hereby ratify and confirm the terms, covenants and provisions of the
Lease which shall remain in full force and effect.

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                                       2

         IN WITNESS WHEREOF, the parties hereto have executed this First
Amendment as of the date first above written.

                                        EASTMAN KODAK COMPANY, LANDLORD

                                        BY: /s/ MEE F. WING
                                            ------------------------------------
                                            MEE F. WING, DIRECTOR, REAL ESTATE

                                        GENENCOR INTERNATIONAL, INC., TENANT

                                        BY: /s/ Thomas J. Pekich
                                            ------------------------------------
                                        NAME:  Thomas J. Pekich
                                        TITLE: Group Vice President, Bioproducts

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