Document:

EX-10.4

 Exhibit 10.4 

FIRST AMENDMENT 

RESTATED AMENDMENT TO 

LICENSE AGREEMENT (B) 

(A2124) 
 This First Amendment after Restated
Amendment to License Agreement (this “First Amendment after Restated Amendment”) is made and effective as of November, 28 2007 by and between the University of Florida Research Foundation, Inc (“UFRF”) a non-stock, non-profit
Florida corporation and Applied Genetic Technologies Corporation (“Licensee”) a corporation organized and existing under the laws of the State of Delaware. 

Whereas, UFRF and Licensee (collectively the “Parties”) entered into that certain patent license agreement known as Agreement
No. 2001-09-13B (the “License Agreement”) covering certain licensed patents, such License Agreement being dated and effective September 25, 2001; and 

Whereas, the Parties have agreed to amend the agreement as previously restated in the Restated Amendment to License Agreement (B) made and
effective January 31, 2005; 
 NOW, THEREFORE, for and in consideration of the mutual covenants and agreements contained herein and other good
and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the Parties hereby agree to amend the License Agreement as follows. 
  

	1.	Section 3.3.1 

 Section 3.3.1, paragraph one, is deleted in its entirety and the
following is substituted in lieu thereof: 
 Licensee agrees to pay UFRF Minimum Royalty payments of [**] per year to be paid in equal quarterly
installments beginning on September 30, 2002, ending with the payment on June 30, 2007, and resuming on September 30, 2009, and every year thereafter for the life of this Agreement. 

 

	2.	Section 3.4,2 

 Section 3.4.2 as amended by the Restated Amendment to License Agreement is
deleted in its entirety and the following is substituted in lieu thereof 
 3.4.2 Licensee agrees to the following development milestones for [**]: 

 

			
	[**]	  	[**]
	[**]	  	[**]
	[**]	  	[**]
	[**]	  	[**]

 Each of the above-described development milestones shall be completed by Licensee and/or its Sublicensees by the agreed dates
or this License may be terminated by UFRF pursuant to Section 7.3 of this Agreement 

  
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 Except as hereby amended, all terms and conditions of the original agreement as amended remain unchanged and
in fill force and effect. 
 IN WITNESS WHEREOF, the parties hereto have duly executed this Agreement on the dates indicated below. 

 

							
	APPLIED GENETIC TECHNOLOGIES CORP.	 		 	
				
	By	 	 /s/ Susan B. Washer
	 		 	Date: 1/9, 2008
		 	Susan B. Washer	 		 	
		 	President and CEO	 		 	

 UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. 

 

							
	By	 	 /s/ David L. Day
	 		 	Date: 1/16, 2008
		 	David L. Day	 		 	
		 	Director, Office of Technology Transfer	 		 	

  
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 - 2 -EX-10.5

 Exhibit 10.5 

STANDARD EXCLUSIVE LICENSE AGREEMENT 

WITH SUBLICENSING TERMS 

TABLE OF CONTENTS 
 Section 1
Definitions 
 Section 2 Grant 

Section 3 Due Diligence 
 Section
4 Consideration 
 Section 5 Certain Warranties and Disclaimers of UFRF; Representations by JHU 

Section 6 Record keeping 
 Section
7 Patent Prosecution 
 Section 8 Infringement and Invalidity 

Section 9 Term and Termination 

Section 10 Assignability 

Section 11 Dispute Resolution Procedures 

Section 12 Product Liability; Conduct of Business 

Section 13 Use of Names 

Section 14 Miscellaneous 

Section 15 Notices 

Section 16 Contract Formation and Authority 

Section 17 United States Government Interests 

Appendix A Development Plan 

Appendix B Development Report 

Appendix C UFRF Royalty Report 

Appendix D Equity Agreement 

This Agreement is made effective the 7th day of October, 2003, (the “Effective Date”) by and between the University of Florida
Research Foundation, Inc. (hereinafter called “UFRF”), a nonstock, nonprofit Florida corporation, Johns Hopkins University (hereinafter “JHU”), a Maryland Corporation, and Applied Genetic Technologies, Inc. and any Affiliates of
Applied Genetic Technologies, Inc. (hereinafter called “Licensee”), a corporation organized and existing under the laws of Florida; 

WHEREAS, JHU and UFRF (which shall collectively be referred to as “Licensors”) each own undivided rights in certain inventions that
are described in the “Licensed Patents” defined below, and Licensors are each willing to grant a license to Licensee under any one or all of the Licensed Patents and Licensee desires a license under all of them; 

  
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 NOW, THEREFORE, in consideration of the mutual covenants and agreements set forth below, the
parties covenant and agree as follows: 
 Section 1 Definitions 
  

	 	1.1	“Licensed Patents” shall refer to and mean all of the following Licensors intellectual property: 

  

	 	1.1.1	the United States patent(s)/patent application(s) entitled [**] and all United States patents and foreign patents and patent applications based on this U.S. application; 

 

	 	1.1.2	any extensions, substitutions, renewals, reissues, re-examinations, continuations, or divisionals of or to any application or patents and all patents issuing thereon, and all patent registrations, supplementary
protection certificates, or cautionary notices thereof both U.S. and foreign; and 

  

	 	1.1.3	any reissues or re-examinations of patents described in 1.1.1 or 1.1.2 above. 

  

	 	1.2	“Licensed Product” and “Licensed Process” shall mean: 

  

	 	1.2.1	In the case of a Licensed Product, any product or part thereof developed by or on behalf of Licensee that: 

  

	 	(a)	is covered in whole or in part by an issued, unexpired claim or a pending claim contained in the Licensed Patents, in any country in which any product is made, used or sold; or 

 

	 	(b)	is manufactured by using a process which is covered in whole or in part by an issued, unexpired claim or a pending claim contained in the Licensed Patents, in any country in which any such process is used or in which
any such product is used or sold. 

  

	 	1.2.2	In the case of a Licensed Process, any process which is covered in whole or in part by an issued, unexpired claim or a pending claim contained in the Licensed Patents in any country in which such process is practiced.

  

	 	1.3	“Net Sales” shall mean the amount invoiced on sales (regardless of uncollectible accounts) of Licensed Product and/or Licensed Processes after deducting, if not already deducted in the amount invoiced:

  

	 	•	 	Trade and/or quantity discounts 

  

	 	•	 	Credits on returns and allowances 

  

	 	•	 	Outbound transportation costs paid 

 The “Net Sales” for a Licensed Product or
Licensed Process that is transferred to a third party for promotional purposes without charge or at a discount shall be the average invoiced price to the customer of that type of Licensed Product and/or Licensed Process during the applicable
calendar quarter. 

  
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 It is understood that Licensed Product may be sold in a combination package, composite or kit
containing other non-licensed products or items. In such event, Selling Price, for purposes of determining royalty payments on the combination package, shall be calculated by the following applicable method: 

 

	 	(i)	By multiplying the Selling Price of that combination package by the fraction A/A+B, where A is the Selling Price, during the royalty paying period in question, of the Licensed Product when sold separately, and B is the
Selling Price, during the royalty paying period in question, of the other components in the combination when sold separately. If no sales of a component occur during a royalty paying period then the production cost of said component shall be used
for the purpose of calculating the royalty on a combination product. In no case shall the royalty on a combination product be less than one (1) percent of the Selling Price. 

 

	 	1.4	The term “Affiliate” shall mean: (a) any person or entity which controls at least fifty percent (50%) of the equity or voting stock of the Licensee or (b) any person or entity fifty percent
(50%) of whose equity or voting stock is owned or controlled by the Licensee or (c) any person or entity of which at least fifty percent (50%) of the equity or voting stock is owned or controlled by the same person or entity owning or
controlling at least fifty percent (50%) of Licensee or (d) any entity in which any officer, employee, or director is also an officer, employee, or director of Licensee or any person who is an officer, employee or director of Licensee.

  

	 	1.5	The term “Sublicensee” shall mean any third party, other than an Affiliate, to whom Licensee confers the right to make, use or sell Licensed Product and/or Licensed Processes. 

 

	 	1.6	“Development Plan” shall mean a written report summarizing the development activities that are to be undertaken by the Licensee to bring Licensed Products and/or Licensed Processes to the market. The
Development Plan is attached as Appendix A. 

  

	 	1.7	“Development Report” shall mean a written account of Licensee’s progress under the Development Plan having at least the information specified on Appendix B to this Agreement, and shall be sent to the
address specified on Appendix B. 

  

	 	1.8	“Licensed Field” shall be all fields of use. 

  

	 	1.9	“Licensed Territory” shall be worldwide. 

  
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 Section 2 Grant 
  

	 	2.1	License.  

 Licensors hereby grant to Licensee an exclusive license, limited to the
Licensed Field and the Licensed Territory, under the Licensed Patents to make, use and sell Licensed Products and/or Licensed Processes with the right to sublicense except that Affiliates expressly shall not have the right to sublicense. During the
term of this Agreement, Licensors will grant no other commercial licenses in the Licensed Field and the Licensed Territory under the Licensed Patents. However, Licensors reserve to themselves and the University of Florida the right to make and use
Licensed Products and/or Licensed Processes under the Licensed Patents for research and educational purposes, including research for any sponsors, including for-profit sponsors. Licensors reserve to themselves and the University of Florida the right
to make and use Licensed Products and/or Licensed Processes under the Licensed Patents for clinical purposes, including research for not for profit sponsors and research for Licensee and Sublicensees. All sponsored research contemplated under this
Section 2.1 shall be conducted on the campus of, and in facilities belonging to, the University of Florida, or JHU and shall be conducted for non-commercial purposes only. No right or license to Licensed Products and/or Licensed Processes shall
be granted or implied to, and no materials will be transferred to, and no confidential information will be disclosed to, said for-profit sponsors. The forgoing notwithstanding, Licensors reserve to themselves and to the University of Florida the
right to use the biological materials that might be covered under Licensed Patents solely for their internal, non-commercial research purposes and to meet all federal and applicable state requirements governing the right to transfer biological
materials. For the purposes of this Section 2.1, materials and confidential information shall mean materials and confidential information developed by or belonging solely to Licensee and/or its Sublicensees. 

 

	 	2.2	Sublicense. 

  

	 	2.2.1	 Licensee may sublicense to others under this Agreement, subject to the terms and conditions of this Paragraph and subject to Licensors prior written
approval of the sublicense agreement. Such approval shall not be unreasonably withheld. As a condition to its validity and enforceability, each sublicense agreement shall: (a) incorporate by reference the terms and conditions of this Agreement,
(b) be consistent with the terms, conditions and limitations of this Agreement, (c) prohibit Sublicensee’s further sublicense of the rights delivered hereunder, (d) name Licensors as an intended third party beneficiaries of the
obligations of Sublicensee without imposition of obligation or liability on the part of Licensors or its Inventors to the Sublicensee, (e) specifically incorporate Sections 5 “Certain Warranties and Disclaimers of UFRF; Representations by
JHU”, 12 “Product Liability; Conduct of Business”, 13 “Use of Names”, into the body of the sublicense agreement, and cause the terms used in therein to 

  
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have the same meaning as in this Agreement, and, (f) bear signature from Licensors indicating Licensors’s review and approval of the sublicense agreement. Licensee shall provide to
Licensors each proposed sublicense agreement, executed by both Licensee and proposed Sublicensee, for review, approval and signature by Licensors. To the extent that any terms, conditions or limitations of any sublicense agreement are inconsistent
with this Agreement, those terms, conditions and limitations are null and void against Licensors, even though Licensors has approved the sublicense in writing. Licensee may grant written, exclusive Sublicenses to third parties. Any agreement
granting a Sublicense shall state that the Sublicense is subject to the termination of this Agreement. Licensee shall have the same responsibility for the activities of any Sublicensee or Affiliate as if the activities were directly those of
Licensee. 

  

	 	2.2.2	In respect to Sublicenses granted by Licensee under 2.2.1 above, Licensee shall pay to UFRF an amount equal to what Licensee would have been required to pay to UFRF had Licensee sold the amount of Licensed Products sold
by such Sublicensee. In addition, if Licensee receives any fees, minimum royalties, or other cash payments in consideration for any rights granted under a Sublicense, and such payments are not based directly upon the amount or value of Licensed
Products sold by the Sublicensee, then Licensee shall pay UFRF [**] of such payments in the manner specified in Section 4.5. Licensee shall not receive from Sublicensees anything of value in lieu of cash payments in consideration for any
Sublicense under this Agreement without the express prior written permission of UFRF. 

  

	 	2.2.3	Licensee shall provide Licensors with a copy of each sublicense agreement within thirty (30) days prior to the execution of the sublicense agreement. 

 

	 	2.3	License to Licensors 

 To the extent permitted by applicable law, Licensee hereby grants
and shall use its best efforts to require its Sublicensee(s) to grant Licensors the right to negotiate for sixty (60) days following disclosure of Improvements (as defined herein) to obtain a nonexclusive, royalty-free, irrevocable, paid-up
license to make and use for research, educational, and clinical purposes, including research for any sponsors, including for-profit sponsors, any and all inventions hereafter made by Licensee (or its Sublicensee(s)) to the extent any such inventions
are Improvements. “Improvements” shall mean any modification of an invention described in Licensed Patents which, if unlicensed, would infringe one or more claims of the Licensed Patents. Licensee shall provide Licensors with a written,
enabling disclosure of each such invention (such as a U.S. patent application), unambiguously identifying it as an invention governed by this paragraph, within six (6) months of filing a patent application thereon. If the parties do not enter
into a license agreement, after negotiating in good faith, within sixty (60) days of 

  
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the date of the disclosure, Licensors’s rights under this Section 2.3 shall be deemed terminated, but only with respect to the invention so disclosed. Any nonexclusive, royalty-free,
irrevocable, paid-up license granted to Licensors to make and use Improvements shall specifically exclude the right to sell, import or export Improvements. 

Section 3 Due Diligence 
  

	 	3.1	Development.  

  

	 	3.1.1	Licensee agrees to and warrants that: it has, or will obtain, the expertise necessary to independently evaluate the inventions of the Licensed Patents; it will establish and actively and diligently pursue the
Development Plan (see Appendix A ) to the end that the inventions of the Licensed Patents will be utilized to provide Licensed Products and/or Licensed Processes for sale in the retail market within the Licensed Field; and until the date of first
commercial sale of Licensed Products, it will supply UFRF with a written Development Report annually fifteen (15) days after the end of the calendar year (see Appendix B ). All development activities and strategies and all aspects of product
design and decisions to market and the like are entirely at the discretion of Licensee, and Licensee shall rely entirely on its own expertise with respect thereto. UFRF’s review of Licensee’s Development Plan is solely to verify the
existence of Licensee’s commitment to development activity and to ensure compliance with Licensee’s obligations to commercialize the inventions of the Licensed Patents, as set forth above, other than those elements of the Development Plan
as designated as Due Diligence milestones in 3.1.2 below. 

  

	 	3.1.2	Licensee agrees that [**] or Licensors shall have the right to terminate the Agreement pursuant to Section 9.3 hereto. In addition, Licensee agrees to the following due diligence elements which if not
accomplished by the following dates, then Licensors shall have the right to terminate the Agreement pursuant to Section 9.3: 

  

	 	(a)	[**] 

  

	 	(b)	[**] 

  

	 	(c)	[**] 

  

	 	(d)	[**] 

  

	 	(e)	[**] 

  
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 Section 4 Consideration 

 

	 	4.1	License Issue Fee. 

 Licensee agrees to pay to UFRF a License Issue Fee of [**] within
thirty (30) days of the Effective Date. 
  

	 	4.2	Issuance of Equity. 

 As further consideration for the rights granted to Licensee by
this Agreement, as of the Effective Date, (i) Licensee will issue to each of JHU and UFRF that number of shares of common stock of Licensee equal to [**] of the total number of issued and outstanding shares of Licensee on the Effective
Date. The issuance of common stock to Licensors under this Section 4.2 shall be made in accordance with that certain Equity Agreement by and between UFRF and Licensee of even date herewith, a copy of which is attached hereto as Appendix D and
incorporated by reference herein. Licensee shall take all actions necessary so that Licensors shall each be issued the number of shares called for in this Agreement and the Equity Agreement attached as Appendix D. 

 

	 	4.3	Running Royalty.  

 In addition to the Section 4.1 License Issue Fee, Licensee
agrees to pay to UFRF as earned royalties a royalty calculated as a percentage of Net Sales in accordance with the terms and conditions of this Agreement. The royalty is deemed earned as of the earlier of the date the Licensed Product and/or
Licensed Process is actually sold and paid for, the date an invoice is sent by Licensee or its Sublicensee(s), or the date a Licensed Product and/or Licensed Process is transferred to a third party for any promotional reasons. The royalty shall
remain fixed while this Agreement is in effect at a rate of [**] of Net Sales. In the event that licenses from third parties are required by Licensee in order to make, have made, use, sell, offer to sell or import any particular Licensed
Product or Licensed Process, then the earned royalty which Licensee is obligated to pay UFRF under this Section 4.3 shall be reduced by [**] for each one dollar ($1.00) in royalties which Licensee is obligated to pay to
third parties under such licenses, further provided, however, that the royalties payable to UFRF under this Section 4.3 shall not be reduced to less than [**] of the applicable Net Sales. 

 

	 	4.4	Other Payments.  

  

	 	4.4.1	Licensee agrees to pay UFRF Minimum Royalty payments of [**] per year to be paid in equal quarterly installments beginning on September 30, 2003 and every year thereafter for the life of this Agreement.

 The Minimum Royalty shall be paid in advance on a quarterly basis for each year in which this Agreement is in effect. The
first Minimum Royalty payment shall be due on October 1, 2003 and shall be in the amount of [**]. The Minimum Royalty for a given year shall be due in advance and shall be paid in quarterly installments on
March 31, June 30, 

  
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September 30, and December 31 for the following quarter. Any Minimum Royalty paid in a calendar year will be credited against the earned royalties for that calendar year. It is
understood that the Minimum Royalties will be applied to earned royalties on a calendar year basis, and that sales of Licensed Products and/or Licensed Processes requiring the payment of earned royalties made during a prior or subsequent calendar
year shall have no effect on the annual Minimum Royalty due UFRF for other than the same calendar year in which the royalties were earned. 
  

	 	4.4.2	In addition to all other payments required under this Agreement, Licensee agrees to pay UFRF Milestone payments, as follows: 

  

			
	 Payment
	  	 Event

	[**]	  	[**]
	[**]	  	[**]
	[**]	  	[**]
	[**]	  	[**]

 For purposes of this Section 4.4.2, “Initiation” shall mean enrollment of the first patient.

  

	 	4.5	Accounting for Payments.  

  

	 	4.5.1	Amounts owing to UFRF under Sections 2.2 and 4.3 shall be paid on a quarterly basis after the amount of Minimum Royalties paid is exceeded, with such amounts due and received by UFRF on or before the thirtieth day
following the end of the calendar quarter ending on March 31, June 30, September 30 or December 31 in which such amounts were earned. The balance of any amounts which remain unpaid more than thirty (30) days after
they are due to UFRF shall accrue interest until paid at the rate of the lesser of one and one-half percent (1.5%) per month or the maximum amount allowed under applicable law. However, in no event shall this interest provision be construed as
a grant of permission for any payment delays. Licensee shall also be responsible for repayment to UFRF of any attorney, collection agency, or other out-of-pocket UFRF expenses required to collect overdue payments due from this Section 4.5.1,
Section 6.2 or any other applicable section of this Agreement. 

  

	 	4.5.2	Except as otherwise directed, all amounts owing to UFRF under this Agreement shall be paid in U.S. dollars to UFRF at the following address: 

University of Florida Research Foundation, Inc. 

219 Grinter Hall 
 PO Box 115500

 Gainesville, Florida  32611-5500 

Attention: Business Manager 

  
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 All royalties owing with respect to Net Sales stated in currencies other than U.S. dollars shall
be converted at the rate shown in the Federal Reserve Noon Valuation - Value of Foreign Currencies on the day preceding the payment. 
  

	 	4.5.3	A certified full accounting statement showing how any amounts payable to UFRF under Sections 2.2 and 4.3 have been calculated shall be submitted to UFRF on the date of each such payment. Such accounting shall be on a
per-country and product line, model or trade name basis and shall be summarized on the form shown in Appendix C of this Agreement. In the event no payment is owed to UFRF because the amount of Minimum Royalties paid has not been exceeded or
otherwise, an accounting demonstrating that fact shall be supplied to UFRF. 

  

	 	4.5.4	Licensors are exempt from paying income taxes under U.S. law. Therefore, all payments due under this Agreement shall be made without deduction for taxes, assessments, or other charges of any kind which may be imposed on
UFRF by any government outside of the United States or any political subdivision of such government with respect to any amounts payable to Licensors pursuant to this Agreement. All such taxes, assessments, or other charges shall be assumed by
Licensee. 

 Section 5 Certain Warranties and Disclaimers of UFRF; Representations by JHU 

 

	 	5.1	UFRF warrants that, except as otherwise provided under Section 16.1 of this Agreement with respect to U.S. Government interests, it is the owner of the Licensed Patents or otherwise has the right to grant the
licenses granted to Licensee in this Agreement. However, nothing in this Agreement shall be construed as: 

  

	 	5.1.1	a warranty or representation by UFRF as to the validity or scope of any right included in the Licensed Patents; 

  

	 	5.1.2	a warranty or representation that anything made, used, sold or otherwise disposed of under the license granted in this Agreement will or will not infringe patents of third parties; 

 

	 	5.1.3	an obligation to bring or prosecute actions or suits against third parties for infringement of Licensed Patents; 

  

	 	5.1.4	an obligation to furnish any know-how not provided in Licensed Patents or any services other than those specified in this Agreement; or 

 

	 	5.1.5	a warranty or representation by UFRF that it will not grant licenses to others to make, use or sell products not covered by the claims of the Licensed Patents which may be similar and/or compete with products made or
sold by Licensee. 

  
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	 	5.2	EXCEPT AS OTHERWISE EXPRESSLY SET FORTH IN THIS AGREEMENT, UFRF MAKES NO REPRESENTATIONS AND EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO WARRANTIES OF MERCHANTABILITY,
FITNESS FOR A PARTICULAR PURPOSE, AND VALIDITY OF PATENT RIGHTS CLAIMS, ISSUED OR PENDING. UFRFASSUMES NO RESPONSIBILITIES WHATSOEVER WITH RESPECT TO USE, SALE, OR OTHER DISPOSITION BY LICENSEE, ITS SUBLICENSEE(S), OR THEIR VENDEES OR OTHER
TRANSFEREES OF PRODUCT INCORPORATING OR MADE BY USE OF INVENTIONS LICENSED UNDER THIS AGREEMENT. 

  

	 	5.3	Duties of the Parties. Licensors are not commercial organizations. They are institutes of research and education. Therefore, Licensors have no ability to evaluate the commercial potential of any Licensed Patents or
Licensed Processes or other license or rights granted in this Agreement. It is therefore incumbent upon Company to evaluate the rights and products in question, to examine the materials and information provided by Licensors, and to determine for
itself the validity of any Licensed Patents or Licensed Processes its freedom to operate, and the value of any Licensed Patents or Licensed Processes or other rights granted 

 

	 	5.4	 Representations by JHU. JHU warrants that it has good and marketable title to its interest in the inventions claimed under Licensed Patents with the
exception of certain retained rights of the United States Government, which may apply if any part of the JHU research was funded in whole or in part by the United States Government. JHU does not warrant the validity of any patents or that practice
under such patents shall be free of infringement. EXCEPT AS EXPRESSLY SET FORTH IN THIS PARAGRAPH 5.4, LICENSEE, LICENSEE’S AFFILIATES AND SUBLICENSEE(S) AGREE THAT THE LICENSED PATENTS ARE PROVIDED “AS IS”, AND THAT JHU MAKES NO
REPRESENTATION OR WARRANTY WITH RESPECT TO THE PERFORMANCE OF LICENSED PRODUCT(S) AND LICENSED PROCESSES INCLUDING THEIR SAFETY, EFFECTIVENESS, OR COMMERCIAL VIABILITY. JHU DISCLAIMS ALL WARRANTIES WITH REGARD TO PRODUCT(S) AND PROCESSES(S) LICENSED
UNDER THIS AGREEMENT, INCLUDING, BUT NOT LIMITED TO, ALL WARRANTIES, EXPRESSED OR IMPLIED, OF MERCHANTABILITY AND FITNESS FOR ANY PARTICULAR PURPOSE. NOTWITHSTANDING ANY OTHER PROVISION OF THIS AGREEMENT, JHU ADDITIONALLY DISCLAIMS ALL OBLIGATIONS
AND LIABILITIES ON THE PART OF JHU AND INVENTORS, FOR DAMAGES, INCLUDING, BUT NOT LIMITED TO, DIRECT, INDIRECT, SPECIAL, AND CONSEQUENTIAL DAMAGES, ATTORNEYS’ AND EXPERTS’ FEES, AND COURT COSTS (EVEN IF JHU HAS BEEN ADVISED OF THE
POSSIBILITY OF SUCH DAMAGES, FEES OR COSTS), ARISING OUT OF OR IN CONNECTION WITH THE MANUFACTURE, USE, OR SALE OF THE PRODUCT(S) AND PROCESSES 

  
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LICENSED UNDER THIS AGREEMENT. LICENSEE, LICENSEE’S AFFILIATES AND SUBLICENSEE(S) ASSUME ALL RESPONSIBILITY AND LIABILITY FOR LOSS OR DAMAGE CAUSED BY A PRODUCT AND/OR PROCESS MANUFACTURED,
USED, OR SOLD BY LICENSEE, ITS SUBLICENSEE(S) AND AFFILIATED COMPANIES WHICH IS A LICENSED PRODUCT(S) OR LICENSED PROCESSES AS DEFINED IN THIS AGREEMENT. 

Section 6 Record keeping 
  

	 	6.1	Licensee and its Sublicensee(s) shall keep books and records sufficient to verify the accuracy and completeness of Licensee’s and its Sublicensee(s)’s accounting referred to above, including without
limitation, inventory, purchase and invoice records, manufacturing records, sales analysis, general ledgers, financial statements, and tax returns relating to the Licensed Products and/or Licensed Processes. Such books and records shall be preserved
for a period not less than six years after they are created, both during and after the term of this Agreement. 

  

	 	6.2	Licensee and its Sublicensee(s) shall take all steps necessary so that UFRF may, within thirty (30) days of its written request, audit, review and/or copy all of the books and records at a single U.S. location to
verify the accuracy of Licensee’s and its Sublicensee(s)’s accounting. Such review may be performed by any authorized employees of UFRF as well as by any attorneys and/or accountants designated by UFRF, upon reasonable notice and during
regular business hours. If a deficiency with regard to any payment hereunder is determined, Licensee and its Sublicensee(s) shall pay the deficiency within thirty (30) days of receiving notice thereof along with applicable interest as described
in Section 4.5.1. If a royalty payment deficiency for a calendar year exceeds [**] of the royalties paid for that year, then Licensee and its Sublicensee(s) shall be responsible for paying UFRF’s out-of-pocket expenses incurred with
respect to such review. 

  

	 	6.3	At any time during the term of this agreement, UFRF may request in writing that Licensee verify the calculation of any past payments owed to UFRF through the means of a self-audit. Within ninety (90) days of the
request, Licensee shall complete a self-audit of its books and records to verify the accuracy and completeness of the payments owed. Within thirty (30) days of the completion of the self-audit, Licensee shall submit to UFRF a report detailing
the findings of the self-audit and the manner in which it was conducted in order to verify the accuracy and completeness of the payments owed. If Licensee has determined through its self-audit that there is any payment deficiency, Licensee shall pay
UFRF the deficiency along with applicable interest under Section 4.5.1 with the submission of the self-audit report to UFRF. 

Section 7 Patent Prosecution 
  

	 	7.1	 UFRF shall diligently prosecute and maintain the Licensed Patents using counsel of its choice. UFRF shall provide Licensee with copies of all patent

  
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applications amendments, and other filings with the United States Patent and Trademark Office and foreign patent offices. UFRF will also provide Licensee with copies of office actions and other
communications received by UFRF from the United States Patent and Trademark Office and foreign patent offices relating to Licensed Patents. Licensee agrees to keep such information confidential. 

 

	 	7.2	Licensee shall be responsible for and pay [**] for the preparation, filing, prosecution, issuance, and maintenance of the Licensed Patents within thirty (30) days of receipt of an invoice from UFRF. It shall
be the responsibility of Licensee to keep UFRF fully apprised of the “small entity” status of Licensee with respect to the U.S. patent laws and with respect to the patent laws of any other countries, if applicable, and to inform UFRF of
any changes in such status, within thirty days of any such change. 

 Section 8 Infringement and Invalidity 

 

	 	8.1	Licensee shall inform Licensors promptly in writing of any alleged infringement of the Licensed Patents by a third party and of any available evidence thereof. 

 

	 	8.2	During the term of this Agreement, Licensors shall have the right, but shall not be obligated, to prosecute at its own expense any such infringements of the Licensed Patents. If Licensors prosecutes any such
infringement, Licensee agrees that Licensors may include Licensee as a co-plaintiff in any such suit, without expense to Licensee. 

  

	 	8.3	If within six (6) months after having been notified of any alleged infringement, Licensors shall have been unsuccessful in persuading the alleged infringer to desist and shall not have brought and shall not be
diligently prosecuting an infringement action, or if Licensors shall notify Licensee at any time prior thereto of its intention not to bring suit against any alleged infringer, then, and in those events only, Licensee shall have the right, but shall
not be obligated, to prosecute at its own expense any infringement of the Licensed Patents, and Licensee may, for such purposes, use the name of Licensors as party plaintiff. No settlement, consent judgment or other voluntary final disposition of
the suit may be entered into without the consent of Licensors, which consent shall not unreasonably. Licensee shall indemnify Licensors against any order for costs that may be made against Licensors in such proceedings. 

 

	 	8.4	In the event that Licensee shall undertake the enforcement by litigation and/or defense of the Licensed Patents by litigation, any recovery of damages by Licensee for any such suit shall be applied first in satisfaction
of any unreimbursed expenses and legal fees of Licensee relating to the suit, and next toward reimbursement of Licensors for any legal fees and unreimbursed expenses. The balance remaining from any such recovery shall be [**].

  

	 	8.5	 In any infringement suit that either party may institute to enforce the Licensed Patents pursuant to this Agreement, the other party hereto shall, at
the request and 

  
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expense of the party initiating such suit, cooperate in all respects and, to the extent possible, have its employees testify when requested and make available relevant records, papers,
information, samples, specimens, and the like. 

  

	 	8.6	In the event a declaratory judgment action alleging invalidity or noninfringement of any of the Licensed Patents shall be brought against Licensee, Licensors, at its option, shall have the right, within thirty
(30) days after commencement of such action, to intervene and take over the sole defense of the action at its own expense. 

  

	 	8.7	In the event Licensee contests the validity of any Licensed Patents, Licensee shall continue to pay royalties and make other payments pursuant to this Agreement with respect to that patent as if such contest were not
underway until the patent is adjudicated invalid or unenforceable by a court of last resort. 

 Section 9 Term and Termination

  

	 	9.1	The term of this license shall begin on the Effective Date of this Agreement and continue until the earlier of the date that no Licensed Patent remains an enforceable patent or the payment of earned royalties under
Section 4.3, once begun, ceases for more than three (3) calendar quarters. 

  

	 	9.2	Licensee may terminate this Agreement at any time by giving at least ninety (90) days written notice of such termination to Licensors. Such a notice shall be accompanied by a statement of the reasons for
termination. 

  

	 	9.3	Licensors may terminate this Agreement by giving Licensee at least sixty (60) days written notice if [**] does not occur on or before the date specified in Section 3.1.2. 

 

	 	9.4	If Licensee at any time defaults in the timely payment of any monies due to Licensors or the timely submission to Licensors of any Development Report, fails to actively pursue the Development Plan, or commits any breach
of any other covenant herein contained, and Licensee fails to remedy any such breach or default within sixty (60) days after written notice thereof by Licensors, Licensors may, at its option, immediately terminate this Agreement by giving
notice of termination to Licensee. 

  

	 	9.5	Licensors may immediately terminate this Agreement upon the occurrence of the second separate default by Licensee within any consecutive three-year period for failure to pay royalties, patent or any other expenses when
due. 

  

	 	9.6	If Licensee shall cease to carry on its business pertaining to Licensed Patents, this Agreement shall terminate upon thirty (30) days notice by Licensors. 

 

	 	9.7	 Upon the termination of this Agreement for any reason, nothing herein shall be construed to release either party from any obligation that matured
prior to the 

  
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effective date of such termination. Licensee shall remain obligated to provide an accounting for and to pay royalties earned to the date of termination, and any Minimum Royalties shall be
prorated as of the date of termination by the number of days elapsed in the applicable calendar year. Licensee may, however, after the effective date of such termination, sell all Licensed Products, and complete Licensed Products in the process of
manufacture at the time of such termination and sell the same, provided that Licensee shall remain obligated to provide an accounting for and to pay running royalties thereon. 

Section 10 Assignability 

This Agreement may not be transferred or assigned by Licensee except with the prior written consent of Licensors. 

Section 11 Product Liability; Conduct of Business 
  

	 	11.1	Licensee and its Sublicensee(s) shall, at all times during the term of this Agreement and thereafter, indemnify, defend and hold UFRF, the Florida Board of Governors, the University of Florida Board of Trustees, the
University of Florida, and each of their directors, officers, employees, and agents, and the inventors of the Licensed Patents, regardless of whether such inventors are employed by the University of Florida at the time of the claim, harmless against
all claims and expenses, including legal expenses and reasonable attorneys’ fees, whether arising from a third party claim or resulting from UFRF’s enforcing this indemnification clause against Licensee, arising out of the death of or
injury to any person or persons or out of any damage to property and against any other claim, proceeding, demand, expense and liability of any kind whatsoever (other than patent infringement claims) resulting from the production, manufacture, sale,
use, lease, consumption, marketing, or advertisement of Licensed Products or Licensed Process(es) or arising from any right or obligation of Licensee hereunder. Notwithstanding the above, UFRF at all times reserves the right to retain counsel of its
own to defend UFRF’s, the Florida Board of Governors’, the University of Florida Board of Trustees’, the University of Florida’s, and the inventor’s interests. 

 

	 	11.2	Licensee warrants that it now maintains and will continue to maintain liability insurance coverage appropriate to the risk involved in producing, manufacturing, selling, marketing, using, leasing, consuming, or
advertising the products subject to this Agreement and that such insurance coverage lists UFRF, the Florida Board of Governors, the University of Florida Board of Trustees, the University of Florida, and the inventors of the Licensed Patents as
additional insureds. Within thirty (30) days after the execution of this Agreement and thereafter annually between January 1 and January 31 of each year, Licensee will present evidence to UFRF that the coverage is being maintained
with UFRF, the University of Florida, and its inventors listed as additional insureds. In addition, Licensee shall provide UFRF with at least thirty (30) days prior written notice of any change in or cancellation of the insurance coverage.

  
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	 	11.3	Product Liability. Prior to initial human testing or first commercial sale of any Licensed Products and Licensed Processes as the case may be in any particular country, Licensee shall establish and maintain, in each
country in which Licensee, an Affiliates of Licensee or Sublicensee(s) shall test or sell Licensed Products or Licensed Processes, product liability or other appropriate insurance coverage in the minimum amount of [**] per claim and will
annually present evidence to JHU that such coverage is being maintained. Upon JHU’s request, Licensee will furnish JHU with a Certificate of Insurance of each product liability insurance policy obtained. JHU shall be listed as an additional
insured in Licensee’s said insurance policies. If such Product Liability insurance is underwritten on a ‘claims made’ basis, Licensee agrees that any change in underwriters during the term of this Agreement will require the purchase
of ‘prior acts’ coverage to ensure that coverage will be continuous throughout the term of this Agreement. 

  

	 	11.4	INDEMNIFICATION JHU and Drs. [**] who are employees of JHU (hereinafter “Inventors”) will have no legal liability exposure to third parties if JHU does not license the Licensed Products and Licensed
Processes, and any royalties JHU and the Inventors may receive is not adequate compensation for such legal liability exposure. Therefore, JHU requires Licensee to protect JHU and Inventors from such exposure to the same manner and extent to which
insurance, if available, would protect JHU and Inventors. Furthermore, JHU and the Inventors will not, under the provisions of this Agreement or otherwise, have control over the manner in which Licensee or its Affiliates or its Sublicensees or those
operating for its account or third parties who purchase Licensed Products and Licensed Processes from any of the foregoing entities, develop, manufacture, market or practice the inventions of Licensed Products and Licensed Processes. Therefore,
Licensee, Affiliates and Sublicensees shall indemnify, defend with counsel reasonably acceptable to JHU, and hold JHU, The Johns Hopkins Health Systems, their present and former trustees, officers, Inventors of Licensed Patents, agents, faculty,
employees and students harmless as against any judgments, fees, expenses, or other costs arising from or incidental to any product liability or other lawsuit, claim, demand or other action brought as a consequence of the practice of said inventions
by any of the foregoing entities, whether or not JHU or said Inventors, either jointly or severally, is named as a party defendant in any such lawsuit and whether or not JHU or the Inventors are alleged to be negligent or otherwise responsible for
any injuries to persons or property. Practice of the inventions covered by Licensed Products and Licensed Processes, by an Affiliate or an agent or a Sublicensee or a third party on behalf of or for the account of Licensee or by a third party who
purchases Licensed Products and Licensed Processes from Licensee, shall be considered Licensee’s practice of said inventions for purposes of this Paragraph. The obligation of Licensee to defend and indemnify as set out in this Paragraph shall
survive the termination of this Agreement, shall continue even after assignment of rights and responsibilities to an affiliate or sublicensee, and shall not be limited by any other limitation of liability elsewhere in this Agreement.

  
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 Section 12 Use of Names 

Licensee and its Sublicensee(s) shall not use the names of UFRF, or of the University of Florida, nor of any of either institution’s
employees, agents, or affiliates, nor the name of any inventor of Licensed Patents, nor any adaptation of such names, in any sales promotion, advertising, or any other form of publicity without the prior written approval of UFRF in each case, except
that Licensee may state that it has received a license from UFRF under one or more or the patents and/or applications comprising the Licensed Patents. 

Licensee, Affiliates and Sublicensees shall not use the name of The Johns Hopkins University or The Johns Hopkins Health System or any of its
constituent parts, such as the Johns Hopkins Hospital or any contraction thereof or the name of Inventors in any advertising, promotional, sales literature or fundraising documents without prior written consent from an authorized representative of
JHU. Licensee, Affiliates and Sublicensees shall allow at least seven (7) business days notice of any proposed public disclosure for JHU’s review and comment or to provide written consent. 

Section 13 Miscellaneous 
  

	 	13.1	This Agreement shall be construed in accordance with the internal laws of the State of Florida 

  

	 	13.2	The parties hereto are independent contractors and not joint venturers or partners. 

  

	 	13.3	Licensee shall insure that it applies patent markings that meet all requirements of U.S. law, 35 U.S.C. §287, with respect to all Licensed Products subject to this Agreement. 

 

	 	13.4	This Agreement constitutes the full understanding between the parties with reference to the subject matter hereof, and no statements or agreements by or between the parties, whether orally or in writing, shall vary or
modify the written terms of this Agreement. Neither party shall claim any amendment, modification, or release from any provisions of this Agreement by mutual agreement, acknowledgment, or otherwise, unless such mutual agreement is in writing, signed
by the other party, and specifically states that it is an amendment to this Agreement. 

 Licensee shall not encumber or otherwise grant a
security interest in any of the rights granted hereunder to any third party. 
  

	 	13.5	 Successors and Assigns. Neither this Agreement nor any of the rights or obligations created herein, except for the right to receive any
remuneration 

  
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hereunder, may be assigned by either party, in whole or in part, without the prior written consent of the other party, except that either party shall be free to assign this Agreement in
connection with any sale of substantially all of its assets without the consent of the other. Such assignment shall be subject to Licensors approval, which approval shall not be unreasonably withheld. This Agreement shall bind and inure to the
benefit of the successors and permitted assigns of the parties hereto. 

  

	 	13.6	Notice of Claim. Each party shall give the other or its representative immediate notice of any suit or action filed, or prompt notice of any claim made, against them arising out of the performance of this Agreement or
arising out of the practice of the inventions licensed hereunder. 

  

	 	13.7	Further Assurances. Each party shall, at any time, and from time to time, prior to or after the Effective Date of this Agreement, at reasonable request of the other party, execute and deliver to the other such
instruments and documents and shall take such actions as may be required to more effectively carry out the terms of this Agreement. 

  

	 	13.8	Delays or Omissions. Except as expressly provided herein, no delay or omission to exercise any right, power or remedy accruing to any party hereto, shall impair any such right, power or remedy to such party nor shall it
be construed to be a waiver of any such breach or default, or an acquiescence therein, or in any similar breach or default be deemed a waiver of any other breach or default theretofore or thereafter occurring. Any waiver, permit, consent or approval
of any kind or character on the part of any party of any breach or default under this Agreement, or any waiver on the part of any party of any provisions or conditions of this Agreement, must be in writing and shall be effective only to the extent
specifically set forth in such writing. All remedies either under this Agreement or by law or otherwise afforded to any party, shall be cumulative and not alternative. 

 

	 	13.9	Survival. All representations, warranties, covenants and agreements made herein and which by their express terms or by implication are to be performed after the execution and/or termination hereof, or are prospective in
nature, shall survive such execution and/or termination, as the case may be. This shall include Section 4.5, Section 5, Section 6, Section 7.1, Section 9, Section 11, Section 12, this Section 13.9.

  

	 	13.10	No Third Party Beneficiaries. Nothing in this Agreement shall be construed as giving any person, firm, corporation or other entity, other than the parties hereto and their successors and permitted assigns, any right,
remedy or claim under or in respect of this Agreement or any provision hereof. 

  

	 	13.11	Headings. Article headings are for convenient reference and not a part of this Agreement. All Appendix are incorporated herein by this reference. 

  
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	 	13.12	Counterparts. This Agreement may be executed in counterparts, each of which shall be deemed an original and all of which when taken together shall be deemed but one instrument. 

 

	 	13.13	Licensee acknowledges that it is subject to and agrees to abide by the United States laws and regulations (including the Export Administration Act of 1979 and Arms Export Contract Act) controlling the export of
technical data, computer software, laboratory prototypes, biological material, and other commodities. The transfer of such items may require a license from the cognizant agency of the U.S. Government or written assurances by Licensee that it shall
not export such items to certain foreign countries without prior approval of such agency. UFRF neither represents that a license is or is not required or that, if required, it shall be issued. 

Section 14 Notices 
 Any
notice required to be given pursuant to the provisions of this Agreement shall be in writing and shall be deemed to have been given 
  

	 	•	 	when delivered personally, 

  

	 	•	 	if sent by facsimile transmission, when receipt thereof is acknowledged at the facsimile number of the recipient as set forth below, 

 

	 	•	 	the second day following the day on which the notice has been delivered prepaid to a national air courier service, or 

  

	 	•	 	five (5) business days following deposit in the U.S. mail if sent certified mail, return receipt requested: 

  

	 	14.1	If to JHU: 

 Licensing and Technology Development 

Johns Hopkins University 
 100
N. Charles Street 
 5th Floor 

Baltimore, MD, 21201 
 Attn:
Director 
  

	 	14.2	If to the University of Florida Research Foundation, Inc.: 

 President 

University of Florida Research Foundation, Inc. 

223 Grinter Hall 
 University of
Florida 
 Post Office Box 115500 

Gainesville, FL 32611-5500 

Facsimile Number: 352-846-0491 

  
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 with a copy to: 

Office of Technology Licensing 

Attn: Director 
 308 Walker Hall

 University of Florida 

Post Office Box 115500 

Gainesville, Florida 32611-5500 

Facsimile Number: 352-392-6600 
  

	 	14.3	If to Licensee: 

 Applied Genetic Technologies Company 

Attention: Chief Executive Officer 

12085 Research Drive, Suite 112 

Alachua, FL 32615 
 with a copy
to: 
 Fred D. Hutchinson, Esq. 

Hutchinson & Mason, PLLC 

3100 Edwards Mill Road, Suite 100 

Raleigh, NC 27612 
 Section 15
Contract Formation and Authority 
  

	 	15.1	No agreement between the parties shall exist unless the duly authorized representative of Licensee and the Director of the Office of Technology Transfer of UFRF and the Associate Provost and Assistant Dean for Licensing
and Technology Development of JHU have signed this document within thirty (30) days of the Effective Date written on the first page of this Agreement. 

  

	 	15.2	UFRF and JHU and Licensee hereby warrant and represent that the persons signing this Agreement have authority to execute this Agreement on behalf of the party for whom they have signed. 

 

	 	15.3	Force Majeure. 

 No default, delay, or failure to perform on the part of Licensee or
Licensors shall be considered a default, delay or failure to perform otherwise chargeable hereunder, if such default, delay or failure to perform is due to causes beyond either party’s reasonable control including, but not limited to: strikes,
lockouts, or inactions of governmental authorities, epidemics, war, embargoes, fire, earthquake, acts of God, or default of common carrier. In the event of such default, delay or failure to perform, any date or times by which either party is
otherwise scheduled to perform shall be extended automatically for a period of time equal in duration to the time lost by reason of the excused default, delay or failure to perform. 

  
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 Section 16 United States Government Interests 

 

	 	16.1	It is understood that the United States Government (through any of its agencies or otherwise) has funded research, [**]during the course of or under which any of the inventions of the Licensed Patents were
conceived or made. The United States Government is entitled, as a right, under the provisions of 35 U.S.C. §202-212 and applicable regulations of Title 37 of the Code of Federal Regulations, to a non-exclusive, nontransferable, irrevocable,
paid-up license to practice or have practiced the inventions of such Licensed Patents for governmental purposes. Any license granted to Licensee in this Agreement shall be subject to such right. 

 

	 	16.2	Licensee agrees that for Licensed Products covered by the Licensed Patents that are subject to the non-exclusive royalty-free license to the United States Government, said Licensed Products will be manufactured
substantially in the United States. Licensee further agrees that it shall abide by all the requirements and limitations of U.S. Code, Title 35, Chapter 18, and implementing regulations thereof, for all patent applications and patents invented in
whole or in part with federal money. 

 IN WITNESS WHEREOF, the parties hereto have duly executed this Agreement on the dates
indicated below. 
 JOHNS HOPKINS UNIVERSITY 
  

			
	 /s/ William P. Tew
	 	Date: October 7, 2003
	William P. Tew, Ph.D.	 	
	Associate Provost and Assistant Dean
	Licensing and Technology Development

 UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. 

 

			
	 /s/ David L. Day
	 	Date: October 1, 2003
	David L. Day	 	
	Director, Office of Technology Transfer

  
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 APPLIED GENETIC TECHNOLOGIES, INC. 

 

					
	By:	 	 /s/ Susan B. Washer
	  	Date: October 1, 2003
	Susan B. Washer, President	  	

  

	
	  

 Reviewed by UFRF’s Attorney:        Reviewed by Licensee’s Attorney 

 

			
	                                	  	
	    (name typed)    	  	(name typed)
	 (Neither attorney shall be deemed a signatory to this Agreement.)

  
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 Appendix A 

Development Plan 
 A
development plan of the scope outlined below shall be submitted to UFRF by Licensee prior to the execution of this agreement. In general, the plan should provide UFRF with a summary overview of the activities that Licensee believes are necessary to
bring products to the marketplace. 
 I. Development Program 

A. Development activities to be undertaken 

(Please break activities into subunits with the date of completion of major milestones) 

1. 
 2. 

3. 
 4. 

B. Estimated total development time 
 II.
Governmental Approval 
 A. Types of submissions required 

B. Government agency, e.g., FDA, EPA, etc. 

III. Proposed Market Approach 
 IV. Competitive Information 

A. Potential competitors 
 B.
Potential competitive devices/compositions 
 C. Known competitor’s plans, developments, technical achievements 

D. Anticipated date of product launch 
 Total
Length: approximately 2-3 pages 

  
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 Appendix B 

Development Report 
 When
appropriate, indicate estimated start date and finish date for activities. 
 I. Date Development Plan Initiated and Time Period Covered by this Report.

 II. Development Report (4-8 paragraphs). 
  

	 	A.	Activities completed since last report including the object and parameters of the development, when initiated, when completed and the results. 

 

	 	B.	Activities currently under investigation, i.e., ongoing activities including object and parameters of such. 

III. Future Development Activities (4-8 paragraphs). 
  

	 	A.	Activities to be undertaken before next report including, but not limited to, the type and object of any studies conducted and their projected starting and completion dates. 

 

	 	B.	Estimated total development time remaining before a product will be commercialized. 

 IV. Changes to Initial
Development Plan (2-4 paragraphs). 
  

	 	A.	Reasons for change. 

  

	 	B.	Variables that may cause additional changes. 

 V. Items to be Provided if Applicable: 

 

	 	A.	Information relating to Licensed Products that has become publicly available, e.g., published articles, competing products, patents, etc. 

 

	 	B.	Development work being performed by third parties, other than Licensee, to include name of third party. 

  

	 	C.	Update of competitive information trends in industry, government compliance (if applicable) and market plan. 

  

	 	D.	Information and copies of relevant materials evidencing the status of any patent applications or other protection relating to Licensed Products or the Licensed Patents. 

PLEASE SEND DEVELOPMENT REPORTS TO: 

University of Florida Research Foundation, Inc. 

Attn: Director 
 308 Walker Hall

 P.O. Box 115500 

Gainesville, FL 32611-5500 

Facsimile: 352-392-6600 

  
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 Appendix C 

UFRF Royalty Report 

Licensee:                       
 Agreement:             

Inventor:                       
  P#:   P             
 Period Covered:
From:             Through:             

Prepared By                    
     Date:             
 Approved
By:                         Date:             

If license covers several major product lines, please prepare a separate report 

for each line. Then combine all product lines into a summary report. 
  

					
	      Report Type:     ̈	 	Single Product Line Report:	 	  

			
		
	                                   ̈	 	Multiproduct Summary Report.    Page 1 of                     
Pages

													
							
	                                   ̈	 	 Product Line Detail.  Line:	 	
                     
        
	 	Tradename:	 	
                     

	 	Page:	 	
                     

					
			
	Report Currency:   ̈	 	U. S. Dollars         ̈   Other	 	  

  

													
	 	  	Gross	  	* Less:	  	Net	  	Royalty	  	Period Royalty Amount
	Country	  	Sales	  	Allowances	  	Sales	  	Rate	  	This Year	  	Last Year
							
	 U.S.A.
	  		  		  		  		  		  	
							
	 Canada
	  		  		  		  		  		  	
							
	 Europe:
	  		  		  		  		  		  	
							
	 Japan
	  		  		  		  		  		  	
							
	 Other:
	  		  		  		  		  		  	
							
	 TOTAL:
	  		  		  		  		  		  	

  

											
	Total Royalty:	 	  
	  	Conversion Rate:	 	  
	  	Royalty in U.S. Dollars:	 	 $

 The following royalty forecast is non-binding and for UFRF’s internal planning purposes only: 

Royalty Forecast Under This Agreement: Next
Quarter:                      Q2:                
      Q3:                      Q4:          
               
 * On a separate page, please indicate the reasons
for returns or other adjustments if significant. 
 Also note any unusual occurrences that affected royalty amounts during this period. 

To assist UFRF’s forecasting, please comment on any significant expected trends in sales volume. 

  
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 Appendix D 

Equity Agreement 
 TABLE OF
CONTENTS 
  

	
	Section 1 Definitions
	Section 2 Issuance of Shares to JHU and UFRF; Closing Deliveries
	Section 3 Representations and Warranties
	Section 4 Miscellaneous Covenants
	Section 5 Termination
	Section 6 Assignability
	Section 7 Miscellaneous
	Section 8 Notices
	Section 9 Integration
	
	Exhibit A Definitions In Equity Agreement
	Exhibit B Articles of Incorporation and Bylaws
	Exhibit C Stock Restrictions
	Exhibit D Financial Statements
	Exhibit E List of Stockholders and Optionholders
	Exhibit F Form of Opinion

 THIS EQUITY AGREEMENT (the “Agreement”) is made effective the     day of
October, 2003 by and between Johns Hopkins University, a Maryland Corporation (hereinafter called “JHU”), and the University of Florida Research Foundation, a nonstock, nonprofit Florida corporation (hereinafter “UFRF”) ,
(collectively “Licensors”)and Applied Genetic Technologies, Inc. (hereinafter called “Licensee” or “AGTC”), a corporation organized and existing under the laws of Florida. 

WHEREAS, JHU, UFRF and Licensee have entered into certain License Agreement with respect to certain inventions owned by Licensors; 

WHEREAS, as an accommodation to Licensee, Licensors are willing to accept shares of common stock of Licensee (the “Shares”) in lieu
of charging Licensee certain fees under the License Agreement. 
 NOW THEREFORE, in consideration of the mutual covenants and agreements set
forth below, the parties covenant and agree as follows: 
 Section 1 Definitions 

For the purpose of this Agreement, the Exhibit A definitions shall apply. Capitalized terms used and not otherwise defined herein shall have
the meanings assigned thereto in the License Agreements. 

  
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 Section 2 Issuance of Shares to Licensors; Closing Deliveries 

 

	 	2.1	Issuance of Shares 

  

	 	2.1.1	On the Effective Date of the License Agreements, Licensee shall issue to UFRF [**] Shares, being equal to [**] of the total number of issued and outstanding Shares of AGTC on the Effective Date calculated
on a fully diluted basis, and Licensee shall deliver, or cause to be delivered, to UFRF a stock certificate, duly signed by appropriate officers of Licensee and issued in UFRF’s name, representing all of the Shares required to be issued to
UFRF. 

  

	 	2.1.2	On the Effective Date of the License Agreements, Licensee shall issue to JHU [**], being equal to [**] of the total number of issued and outstanding Shares of AGTC on the Effective Date calculated on a
fully diluted basis, and Licensee shall deliver, or cause to be delivered, to JHU a stock certificate, duly signed by appropriate officers of Licensee and issued in JHU’s name, representing all of the Shares required to be issued to JHU.

  

	 	2.1.3	All Shares shall be fully-paid and non-assessable upon their issuance to Licensors. JHU’s and UFRF’s execution of this Agreement and the License Agreements shall be deemed full consideration for the issuance
of the Shares, and no additional consideration for such Shares shall be due from Licensors. No Shares shall be subject to any restrictions on their transfer other than the restrictions specified in Exhibit C hereto. 

 

	 	2.1.4	JHU and UFRF shall each be responsible for providing the appropriate information concerning stock certificate issuance to Applied Genetic Technologies Corporation, or any other future licensees of the Inventions, as
appropriate. 

  

	 	2.2	Closing Deliveries 

 On the Effective Date, in addition to the certificates evidencing
the Shares, Licensee shall deliver to JHU and UFRF the following: 
  

	 	2.2.1	a certificate from Licensee, dated as of the Effective Date and signed by the Secretary or an Assistant Secretary of Licensee, certifying that the attached copies of the Certificate of Incorporation, Bylaws of Licensee,
and resolutions of the Board of Directors of Licensee approving the License Agreements, this Agreement and the transactions contemplated thereby, are all true, complete and correct and that such resolutions remain unamended and in full force and
effect. 

  

	 	2.2.2	an opinion of Fred D. Hutchinson, Esq., counsel to Licensee, dated as of the Effective Date and substantially in the form of Exhibit F hereto. 

  
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 Section 3 Representations and Warranties 

 

	 	3.1	Representations and Warranties by Licensee 

 Licensee represents and warrants to
Licensors that: 
  

	 	3.1.1	Licensee is a duly organized and validly existing corporation under the laws of the State of Florida with adequate power and authority to conduct the business in which it is now engaged or currently proposed to be
engaged, and Licensee is duly qualified to do business as a foreign corporation and is in good standing in such other states or jurisdictions as is necessary to enable it to carry on its business or own its properties. 

 

	 	3.1.2	There are no actions, suits, or proceedings pending or threatened against or affecting Licensee, its officers or directors in their capacity as such, its properties, or its patents in any court or before any
governmental or administrative agency, which can have any material adverse effect on the business as now conducted or as currently proposed to be conducted, on the properties, the financial condition, or income of Licensee, or the transactions
contemplated by this Agreement or the License Agreements and Licensee is not in default under any order or judgment of any court or governmental or administrative agency. 

 

	 	3.1.3	Licensee is not a party to any agreement or instrument, or subject to any charter, bylaw, or other corporate restrictions materially adversely affecting its business and operations, present or prospective, or its
property, assets, or condition, financial or otherwise. 

  

	 	3.1.4	Licensee is not in default or breach in the performance, observance, or fulfillment of any of the obligations, covenants, or conditions contained in any bond, debenture, note, or other evidence of indebtedness or any
contract or other agreement of Licensee. 

  

	 	3.1.5	This Agreement has been duly authorized, executed, and delivered on behalf of Licensee and constitutes the valid and binding agreement of Licensee, enforceable in accordance with its terms, and Licensee has full power
and lawful authority to issue, sell, and repurchase the Shares on the terms and conditions herein set forth. 

  

	 	3.1.6	Consummation of the transactions contemplated by this Agreement in compliance with provisions of this Agreement will not result in any breach of any of the terms, conditions, or provisions of, or constitute a default
under, or result in the creation of any lien, charge, or encumbrance on, any property or assets of Licensee pursuant to any indenture, mortgage, deed of trust, agreement, corporate charter, bylaws, contract, or other instrument to which Licensee is
a party or by which Licensee may be bound or any law, rule, regulation, qualification, license, order or judgment applicable to Licensee or any of its property. 

  
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	 	3.1.7	Licensee is in compliance with all federal, state and local environmental laws and there are no conditions currently existing or contemplated which are likely to subject Licensee to damages, penalties, injunctive
relief, removal costs, remedial costs or cleanup costs under any such laws or assertions thereof. 

  

	 	3.1.8	Attached hereto as Exhibit B and hereby made a part hereof are the Articles of Incorporation (including any amendments thereto) and Bylaws (including any amendments thereto) of Licensee in effect on the date hereof.

  

	 	3.1.9	Pursuant to its Articles of Incorporation, Licensee is authorized to issue 21,290,965 Shares, of which 20,604,160 shares are Common Stock, $0.001 par value per share, and of which 686,805 shares are Preferred Stock,
$0.001 par value per share of which 18,364,810 Shares are issued and outstanding. All issued and outstanding Shares are, and the Shares issuable to Licensors will be, validly issued, fully paid and nonassessable, and are not subject to any
preemptive rights. There are no other authorized or outstanding Equity Securities of any class, kind, or character, and there are no outstanding subscriptions, options, warrants, or other agreements, or commitments obligating Licensee to issue any
additional shares of its capital stock of any class, or any options or rights with respect thereto, or any securities convertible into any shares of stock of any class. No person has any preemptive rights, rights of first refusal, “tag
along” rights, rights of co-sale or any similar rights with respect to the issuance of the Shares contemplated hereby. 

  

	 	3.1.10	Attached hereto as Exhibit C and hereby made a part hereof is a list of all restrictions on the transfer of any Shares or other securities of Licensee and all agreements between any shareholders or convertible debt
holders of Licensee regarding the valuation, voting or transfer of any Shares or other securities of Licensee. 

  

	 	3.1.11	Attached hereto as Exhibit D and hereby made a part hereof are the unaudited Financial Statements of Licensee for the year ended July 31, 2003. These financial statements are true and complete and are in accordance
with the books and records of Licensee. As of the date of the most recent financial statements provided to Licensors under this Agreement, Licensee has no material liabilities, absolute or contingent, that are not reflected in such financial
statements except obligations incurred in the ordinary course of business and the License Agreements. 

  

	 	3.1.12	 Since the date of the most recent financial statements provided to Licensors under this Agreement, there has been no: (a) material adverse

  
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change in the condition, financial or otherwise, of Licensee other than changes in the ordinary course of business; (b) damage or loss, whether or not covered by insurance, materially and
adversely affecting Licensee’s properties or business taken as a whole; and (c) declaration or setting aside, or payment of any dividend or other distribution in respect of the stock of Licensee or any direct or indirect redemption,
purchase or other acquisition of such shares. 

  

	 	3.1.13	Licensee has timely filed all tax returns and reports required to be filed by it. Licensee has timely paid all taxes, interest and penalties required to be paid pursuant to said returns or otherwise required to be paid
by it. 

  

	 	3.1.14	Attached hereto as Exhibit E is a true and complete record of (i) issued and outstanding Shares as of the Effective Date and the holders thereof, and (ii) Shares issuable under options, warrants or other
convertible equity or debt instruments outstanding as of the Effective Date, whether vested or non-vested, restricted or unrestricted, the holders thereof, the exercise price or conversion price thereof and an outline of all other material terms
with respect thereto. 

  

	 	3.2	Representations and Warranties by Licensors 

 Licensors represent and warrant to
Licensee that: 
  

	 	3.2.1	Licensors are acquiring the Shares for investment for their own accounts and not with a view to resale or distribution within the meaning of the Securities Act, and Licensors do not intend to divide their participation
with others or to resell or otherwise dispose of all or any part of the Shares without registration under the Securities Act, except to Licensee or unless and until it determines at some future date that changed circumstances, not now in its
contemplation, make such disposition advisable. 

  

	 	3.2.2	This Agreement has been duly authorized, executed, and delivered on behalf of Licensors and constitutes the valid and binding agreement of Licensors, enforceable in accordance with its terms, and Licensors both have
full power and lawful authority to acquire the Shares on the terms and conditions herein set forth. 

  

	 	3.3	Survival and Timing of Warranties 

 The warranties and representation made in this
Section 3 shall survive the closing of any issuance of shares to JHU or UFRF. The warranties and representations made in this Section 3 shall be true and correct as of the date of this Agreement and as of the date the Shares are issued to
Licensors. 

  
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 Section 4 Miscellaneous Covenants 

 

	 	4.1	Financial Statements and Other Information 

 As long as JHU or UFRF own any Equity
Securities, Licensee shall promptly provide to those of the two institutions owning shares at that time such Financial Agreements, amendments to or restatements of its Articles of Incorporation or Bylaws, stock transfer restrictions and agreements
among shareholders with respect to the valuation, transfer or voting of Shares and amendments thereto as may be effected from time to time, and such other information respecting the business, affairs, and financial condition of Licensee as the two
institutions owning shares at that time may reasonably request. Financial Statements shall be provided within the time that such Financial Statements are required to be provided to holders of preferred stock of Licensee. Licensors’s
representatives may visit and inspect any of the properties, books and information of Licensee, upon reasonable notice, during business hours and in a manner not disruptive to the business of the Licensee. 

 

	 	4.2	Issuance of Shares/Options to Affiliates/Founders 

 Licensee shall not issue any Equity
Securities (including Shares) to any of the shareholders of Licensee listed on Exhibit A attached hereto (the “Founders”), Affiliate thereof or Affiliate of Licensee for less than the fair market value of that security. Licensee shall have
the burden of proving that the consideration to be paid for any such Equity Securities equals the fair market value of such Equity Securities issued. 
  

	 	4.3	Piggyback Registration Rights 

 Licensors shall be granted the same incidental or
piggyback registration rights that are granted to the purchasers of Series A Preferred Stock of Licensee and shall be made a party to the registration rights agreement with the holders of such Series A Preferred Stock. 

 

	 	4.4	Rule 144 Reporting  

 With a view to making available to Licensors the benefits of
certain rules and regulations of the Commission which may permit Licensors to sell securities of Licensee to the public without registration, Licensee agrees to: 
  

	 	4.4.1	Make and keep public information available, as those terms are understood and defined in Rule 144 under the Securities Act, at all times following the effective date of the first registration under the Securities Act
filed by Licensee for an offering of its securities to the general public; 

  

	 	4.4.2	Use its best efforts to file with the Commission in a timely manner all reports and other documents required of Licensee under the Securities Act and the Exchange Act at any time following registration of any of its
securities under the Securities Act or Exchange Act; and 

  
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	 	4.4.3	So long as JHU or UFRF owns any Shares, furnish to the institutions owning shares at that time forthwith upon request a written statement by Licensee as to its compliance with the reporting requirements of Rule 144 (at
any time following the effective date of the first registration statement filed by Licensee for an offering of its securities to the general public), and of the Securities Act and the Exchange Act following registration of any of its securities
under the Securities Act or Exchange Act, a copy of the most recent annual or quarterly report of Licensee, and such other reports and documents so filed as Licensors may reasonably request in availing itself of any rule or regulation of the
Commission allowing Licensors to sell any such securities without registration. 

  

	 	4.5	Transfer or Assignment of Registration Rights  

 The rights to cause Licensee to
register the securities granted to Licensors hereunder may be transferred or assigned by Licensors to a transferee or assignee of any of Licensors’s Shares; provided, however, that such transfer or assignment of Shares was permitted under this
Agreement. 
 Section 5 Termination 
  

	 	5.1	Unless terminated sooner by either party as provided below, this Agreement shall terminate on the date that, with respect to each institution, after having been issued Shares hereunder, no longer owns any Equity
Securities. If this Agreement terminates automatically as provided in this Section 5.1, the License shall remain in effect according to the terms specified therein. 

 

	 	5.2	If Licensee at any time fails to issue Shares to either Licensors on a timely basis, or otherwise commits a material breach of this Agreement, or if any of the representations or warranties made by Licensee are untrue
in any material respect as of any date on which they are required to be true and correct, and Licensee fails to remedy any such breach or default within thirty (30) days after written notice thereof by Licensors, Licensors may, at its option,
terminate either this Agreement, the License , or all of them. 

 Section 6 Assignability 

Except as set forth in Section 4.1, neither party may assign its rights or obligations under this Agreement, except that Licensee may
assign this Agreement in connection with the sale of all or substantially all of the assets or stock of the Licensee, whether by merger, acquisition or otherwise, if the successor assumes all of the Licensee’s obligations hereunder. 

Section 7 Miscellaneous 

This Agreement shall be construed exclusively in accordance with the internal laws of the State of Florida. 

  
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 Section 8 Notices 

Any notice required to be given pursuant to the provisions of this Agreement shall be in writing and shall be deemed to have been given at the
earlier of the time when actually received as a consequence of any effective method of delivery, including but not limited to hand delivery, transmission by telecopier, or delivery by a professional courier service or the time when sent by certified
or registered mail addressed to the party for whom intended at the address below or at such changed address as the party shall have specified by written notice, provided that any notice of change of address shall be effective only upon actual
receipt: 
 To JHU: 
 Director

 Licensing and Technology Development 

Johns Hopkins University 
 100
N. Charles Street 
 5th Floor 

Baltimore, MD, 21201 
 to UFRF:

 University of Florida Research Foundation, Inc. 

219 Grinter Hall 
 PO Box 115500

 Gainesville, Florida 32611-5500 

Attention: President 
 with a
copy to: 
 Office of Technology Licensing 

University of Florida 
 3rd
Floor Walker Hall 
 PO Box 115500 

Gainesville, Florida 32611-5500 

Attention: Director 
 to
Licensee: 
 Applied Genetic Technologies Company 

Attention: Chief Executive Officer 

12085 Research Drive, Suite 112 

Alachua, FL 32615 
 with a copy
to: 
 Fred D. Hutchinson, Esq. 

Hutchinson & Mason, PLLC 

3100 Edwards Mill Road, Suite 100 

Raleigh, NC 27612 

  
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 Section 9 Integration 

This Agreement constitutes the full understanding between the parties with reference to the subject matter hereof, and no statements or
agreements by or between the parties, whether orally or in writing, except as provided for elsewhere in this Section 9, made prior to or at the signing with respect to the subject matter hereof, shall vary or modify the written terms of this
Agreement. Neither party shall claim any amendment, modification, or release from any provisions of this Agreement by mutual agreement, acknowledgment or otherwise, unless such mutual agreement is in writing, signed by the other party, and
specifically states that it is an amendment to this Agreement. 
 IN WITNESS WHEREOF, the parties hereto have duly executed this Agreement
on the dates indicated below. 
 JOHNS HOPKINS UNIVERSITY 
  

			
	 /s/ William P. Tew
	 	Date: October 7, 2003
	William P. Tew, Ph.D.	 	
	Associate Provost and Assistant Dean
	Licensing and Technology Development

 UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. 

 

			
	 /s/ David L. Day
	 	Date: October 1, 2003
	David L. Day	 	
	Director, Office of Technology Transfer

 APPLIED GENETIC TECHNOLOGIES, INC. 
  

					
	By:	 	 /s/ Susan B. Washer
	  	Date: October 1, 2003
	Susan B. Washer, President	  	

  
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 Exhibit A 

Definitions In Equity Agreement 
  

	(1)	“Shares” shall mean shares of Licensee’s common stock, $.01 par value per share. 

  

	(2)	“License Agreement” shall mean the license agreement entered into between Licensors and Licensee of even date herewith. 

  

	(3)	“Affiliate” shall mean any person who is related by blood or marriage to any person or entity who owns more than twenty percent of the issued and outstanding shares of Licensee or to any officer, director, or
employee of Licensee or any entity in which any such person has a direct or indirect beneficial ownership interest or for which any such person serves as a director, officer or employee. 

 

	(4)	“Financial Statements” shall mean a balance sheet, and the related statements of earnings, stockholders’ equity and cash flow as of the end of the last fiscal year that has been completed when the
statements are to be provided to Licensors and a balance sheet and income statement as of the end of the last fiscal quarter, which financial statements shall be in the form and delivered at the time that such financial statements are delivered to
holders of preferred stock of Licensee. Financial Statements shall be true and complete and prepared in accordance with the books and records of Licensee and with generally accepted accounting principles. 

 

	(5)	“Equity Securities” shall mean the Shares, any other capital stock of Licensee (including preferred shares), and any securities of Licensee that are convertible into capital stock of Licensee or that carry a
right to subscribe to or acquire capital stock of Licensee. 

  

	(6)	“Register,” “Registered,” and “Registration” shall refer to a registration effected by preparing a filing a Registration Statement in compliance with the Securities Act, and the declaration
or ordering of the effectiveness of such Registration Statement. 

  

	(7)	“Securities Act” shall mean the Securities Act of 1933, as amended, or any similar federal statute, and the rules and regulations of the Securities and Exchange Commission issued under such act, as they each
may, from time to time, be in effect. 

  

	(8)	“Commission” shall mean the Securities and Exchange Commission or any other federal agency at the time administering the Securities Act. 

 

	(9)	“Exchange Act” shall mean the Securities Exchange Act of 1934, as amended. 

  
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 Exhibit B 

Articles of Incorporation and Bylaws 

  
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