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Exhibit 10.8    
    

Villa
Guardia, 24th March 2004 

	

 	
 	

Messrs.
	Administration and Finance	 	SIRTON PHARMACEUTICALS S.p.A.
	 	 	Piazza XX Settembre 2

22079 VILLA GUARDIA COMO
	SC/vs	 	 

        With
reference to the investment programmes under way, for an improved management of the bank loans granted, we are writing to request you to grant us a loan of Euro 1,000,000 in the
ways and under the conditions you suggest. 

        We
trust we will receive your positive reply on this matter, 

Your
sincerely, 

   

    

	 	 	Gentium S.p.A.

Administration and Finance

/s/  Sauro Carsana      
 Dr. Sauro Carsana

	

Villa Guardia, 28th March 2004	
 	

 
	 	 	Messrs.

GENTIUM S.p.A.

Piazza XX Settembre, 2

22079 VILLA GUARDIA—COMO
	

Deputy Chairperson's Office	 	 
	

LIF/vs	
 	

 

        In
reply to your letter of 24/03/2004, we wish to inform you that we are willing to put at your disposal the sum of Euro 1,000,000 by way of loan under the following conditions: 

	1.
	Duration

        Until
1/10/2008 

	2.
	Reimbursement

        In
a single payment, with the faculty of the borrower to return the sum in advance with 30 days' written notice. 

	3.
	Remuneration

        Fixed
rate of 3.5%. 

	4.
	Payment

        Deferred
annual. 

        Confident
that we have fulfilled your request in the best ways possible, we would be grateful if, for formal regularity, you confirm this letter in full. 

	Yours sincerely,	 	 
	

 	
 	

Sirton Pharmaceuticals S.p.A.
	 	 	The Deputy Chairperson

/s/  Laura Iris Ferro      
 Dr. Laura Iris Ferro

	

 	
 	

 
	Villa Guardia, 29th March 2004	 	 
	 	 	Messrs.

SIRTON PHARMACEUTICALS S.P.A.

Piazza XX Settembre, 2

22079 VILLA GUARDIA—COMO
	Administration and Finance	 	 
	

CS/vs	
 	

 

        In
reply to your letter of 26/03/2004, please find below its full contents which we accept: 

        "In
reply to you letter of 24/03/04, we wish to inform you that we are willing to put at your disposal the sum of Euro 1,000,000 by way of loan under the following conditions: 

	1.
	Duration

        Until
1/10/2008 

	2.
	Reimbursement 

        In
a single payment, with the faculty of the borrower to return the sum in advance with 30 days' written notice. 

	3.
	Remuneration

        Fixed
rate of 3.5%. 

	4.
	Payment

        Deferred
annual. 

        Confident
that we have fulfilled your request in the best ways possible, we would be grateful if, for formal regularity, you confirm this letter in full." 

        Thanking
your for your helpfulness, 

	Yours sincerely,	 	 
	

 	
 	

Gentium S.p.A.

Administration and Finance

/s/  S. Carsana      
 Dr. Sauro Carsana

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Exhibit 10.8QuickLinks
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Exhibit 10.9    
    

	Villa Guardia, 6th May 2004	 
	

 	

Messrs.

SIRTON PHARMACEUTICALS S.p.A.

Piazza XX Settembre 2

22079 VILLA GUARDIA—COMO
	Administration and Finance	 
	

SC/vs	

 

        With
reference to the investment programmes under way, for an improved management of the bank loans granted, we are writing to request you to grant us a loan of Euro 1,000,000 in the
ways and under the conditions you suggest. 

        We
trust we will receive your positive reply on this matter, 

Your
sincerely, 

	

 	

Gentium S.p.A.

Administration and Finance

/s/  S. Carsana      
 Dr. Sauro Carsana

	Villa Guardia, 7th May 2004	 
	

 	

Messrs.

GENTIUM S.p.A.

Piazza XX Settembre, 2

22079 VILLA GUARDIA—COMO
	Deputy Chairperson's Office	 
	

LIF/vs	

 

        In
reply to your letter of 6/05/2004, we wish to inform you that we are willing to put at your disposal the sum of Euro 1,000,000 by way of loan under the following conditions: 

	1.
	Duration

Until
1/10/2008 

	2.
	Reimbursement

In
a single payment, with the faculty of the borrower to return the sum in advance with 30 days' written notice. 

	3.
	Remuneration 

Fixed
rate of 3.5%. 

	4.
	Payment

Deferred
annual. 

        Confident
that we have fulfilled your request in the best ways possible, we would be grateful if, for formal regularity, you confirm this letter in full. 

Yours
sincerely, 

	

 	

Sirton Pharmaceuticals S.p.A.

The Deputy Chairperson

/s/  Laura Iris Ferro      
 Dr. Laura Iris Ferro

(signed)

	Villa Guardia, 10th May 2004	 
	

 	

Messrs.

SIRTON PHARMACEUTICALS S.P.A.

Piazza XX Settembre, 2

22079 VILLA GUARDIA—COMO
	Administration and Finance	 
	

CS/vs	

 

        In
reply to your letter of 7/05/2004, please find below its full contents which we accept and sign for acceptance: 

        "In
reply to your letter of 6/05/04, we wish to inform you that we are willing to put at your disposal the sum of Euro 1,000,000 by way of loan under the following conditions: 

	1.
	Duration

Until
1/10/2008 

	2.
	Reimbursement 

In
a single payment, with the faculty of the borrower to return the sum in advance with 30 days' written notice. 

	3.
	Remuneration

Fixed
rate of 3.5%. 

	4.
	Payment

Deferred
annual. 

        Confident
that we have fulfilled your request in the best ways possible, we would be grateful if, for formal regularity, you confirm this letter in full." 

Thanking
your for your helpfulness, 

Yours
sincerely, 

	

 	

Gentium S.p.A.

Administration and Finance

/s/  S. Carsana      
 Dr. Sauro Carsana

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Exhibit 10.9QuickLinks
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Exhibit 10.10    
    

	

Villa Guardia, 11th June 2004	
 	

 
	

 	
 	

Messrs.

SIRTON PHARMACEUTICALS S.p.A.

Piazza XX Settembre 2

22079 VILLA GUARDIA—COMO
	Administration and Finance	 	 
	

SC/vs	
 	

 

        With
reference to the investment programmes under way, for an improved management of the bank loans granted, we are writing to request you to grant us a loan of Euro 400,000 in the ways
and under the conditions you suggest. 

        We
trust we will receive your positive reply on this matter, 

	Your sincerely,	 	 
	

 	
 	

Gentium S.p.A.

Administration and Finance

/s/  S. Carsana      
 Dr. Sauro Carsana

	

 	
 	

 
	Villa Guardia, 14th June 2004	 	 
	 	 	Messrs.

GENTIUM S.p.A.

Piazza XX Settembre, 2

22079 VILLA GUARDIA—COMO
	Deputy Chairperson's Office	 	 
	

LIF/vs	
 	

 

        In
reply to your letter of 11/06/2004, we wish to inform you that we are willing to put at your disposal the sum of Euro 400,000 by way of loan under the following conditions: 

	1.
	Duration

        Until
1/10/2008 

	2.
	Reimbursement

        In
a single payment, with the faculty of the borrower to return the sum in advance with 30 days' written notice. 

	3.
	Remuneration

        Fixed
rate of 3.5%. 

	4.
	Payment

        Deferred
annual. 

        Confident
that we have fulfilled your request in the best ways possible, we would be grateful if, for formal regularity, you confirm this letter in full. 

	Yours sincerely,	 	 
	

 	
 	

Sirton Pharmaceuticals S.p.A.
	 	 	The Deputy Chairperson

/s/  Laura Iris Ferro      
 Dr. Laura Iris Ferro
	(signed)	 	 

	

 	
 	

 
	Villa Guardia, 15th June 2004	 	Messrs.

SIRTON PHARMACEUTICALS S.P.A.

Piazza XX Settembre, 2

22079 VILLA GUARDIA—COMO
	Administration and Finance	 	 
	

CS/vs	
 	

 

        In
reply to your letter of 14/06/2004, please find below its full contents which we accept and sign for acceptance: 

        "In
reply to your letter of 10/06/04, we wish to inform you that we are willing to put at your disposal the sum of Euro 400,000 by way of loan under the following conditions: 

	1.
	Duration

        Until
1/10/2008 

	2.
	Reimbursement 

        In
a single payment, with the faculty of the borrower to return the sum in advance with 30 days' written notice. 

	3.
	Remuneration

        Fixed
rate of 3.5%. 

	4.
	Payment

        Deferred
annual. 

        Confident
that we have fulfilled your request in the best ways possible, we would be grateful if, for formal regularity, you confirm this letter in full." 

        Thanking
your for your helpfulness, 

	Yours sincerely,	 	 
	

 	
 	

Gentium S.p.A.

Administration and Finance

/s/  S. Carsana      
 Dr. Sauro Carsana

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Exhibit 10.10QuickLinks
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Exhibit 10.11    
    

	Villa Guardia, 5th July 2004	 	 
	 	 	Messrs.

SIRTON PHARMACEUTICALS S.p.A.

Piazza XX Settembre 2

22079 VILLA GUARDIA—COMO
	Administration and Finance	 	 
	

SC/vs	
 	

 

        With
reference to the investment programmes under way, for an improved management of the bank loans granted, we are writing to request you to grant us a loan of Euro 600,000 in the ways
and under the conditions you suggest. 

        We
trust we will receive your positive reply on this matter, 

	Your sincerely,	 	 
	

 	
 	

Gentium S.p.A.

Administration and Finance

/s/  S. Carsana      
 Sauro Carsana

	Villa Guardia, 6th July 2004	 	 
	 	 	Messrs.

GENTIUM S.p.A.

Piazza XX Settembre, 2

22079 VILLA GUARDIA—COMO
	Deputy Chairperson's Office	 	 
	

LIF/vs	
 	

 

        In
reply to your letter of 05/07/2004, we wish to inform you that we are willing to put at your disposal the sum of Euro 600,000 by way of loan under the following conditions: 

	1.
	Duration

Until
1/10/2008 

	2.
	Reimbursement

In
a single payment, with the faculty of the borrower to return the sum in advance with 30 days' written notice. 

	3.
	Remuneration 

Fixed
rate of 3.5%. 

	4.
	Payment

Deferred
annual. 

        Confident
that we have fulfilled your request in the best ways possible, we would be grateful if, for formal regularity, you confirm this letter in full. 

	Yours sincerely,	 	 
	

 	
 	

Sirton Pharmaceuticals S.p.A.

The Deputy Chairperson

/s/  Laura Iris Ferro      
 Dr. Laura Iris Ferro

	Villa Guardia, 7th July 2004	 	 
	 	 	Messrs.

SIRTON PHARMACEUTICALS S.P.A.

Piazza XX Settembre, 2

22079 VILLA GUARDIA—COMO
	Administration and Finance	 	 
	

CS/vs	
 	

 

        In
reply to your letter of 06/07/2004, please find below its full contents which we accept and sign for acceptance: 

        "In
reply to your letter of 05/07/04, we wish to inform you that we are willing to put at your disposal the sum of Euro 600,000 by way of loan under the following conditions: 

	1.
	Duration

Until
1/10/2008 

	2.
	Reimbursement 

In
a single payment, with the faculty of the borrower to return the sum in advance with 30 days' written notice. 

	3.
	Remuneration

Fixed
rate of 3.5%. 

	4.
	Payment

Deferred
annual. 

        Confident
that we have fulfilled your request in the best ways possible, we would be grateful if, for formal regularity, you confirm this letter in full." 

        Thanking
your for your helpfulness, 

	Yours sincerely,	 	 
	

 	
 	

Gentium S.p.A.

Administration and Finance

/s/  S. Carsana      
 Dr. Sauro Carsana

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Exhibit 10.11

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