Document:

Exhibit

August 17, 2015

Cancer Genetics, Inc. 
Meadows Office Complex 
201 Route 17 North, 2nd Floor 
Rutherford, NJ 07070
Attention: Mr. Panna Sharma, Chief Executive Officer
     and President

Re:    First Amendment to Amended and Restated Asset Purchase Agreement 

Dear Panna:

Reference is made to that certain Amended and Restated Asset Purchase Agreement dated August  17, 2015 (the “APA”), between Response Genetics, Inc., a Delaware corporation and Chapter 11 Debtor and Debtor in Possession in the Bankruptcy Case pending in the Bankruptcy Court (“Seller”), and Cancer Genetics, Inc., a Delaware corporation (“Buyer”).  Capitalized terms used but not otherwise defined herein shall have the respective meanings ascribed to them in the APA.

As discussed, Seller and Buyer wish to extend the deadline set forth in Section 7.1(h) of the APA.  Accordingly, upon, Buyer’s and Seller’s mutual execution and delivery of this letter agreement, Section 7.1(h) of the APA shall be amended by striking the phrase “5:00 p.m., Eastern Time, on August 17, 2015” and inserting in its place “5:00 p.m., Eastern Time, August 20, 2015.”

Each of Seller and Buyer further acknowledges and agrees that (i) this letter agreement may be executed in counterparts, each of which shall be deemed an original, but all of which together shall be deemed to be one and the same instrument, (ii) a facsimile of its signature hereto or its signature hereto transmitted electronically in portable document format (PDF) shall be deemed and treated for all purposes of execution to be as valid as an original signature hereto, and (iii) except only to the extent expressly set forth herein, the APA shall be unchanged and shall remain in full force and effect.

[Signatures on next page.]

Assuming that this letter agreement accurately sets forth our understanding, please sign where indicated below on behalf of Buyer and return the signed counterpart to us.  Thank you for your cooperation and attention to this matter.

Sincerely,

Response Genetics,, Inc.,  
a Delaware corporation and Chapter 11
Debtor and Debtor in Possession

By:     /s/ Thomas Bologna    
Name:    Thomas Bologna
Title:    Chief Executive Officer

Acknowledged and agreed to effective as of the
date first written above, by:

Cancer Genetics, Inc.,  
a Delaware corporation

By:     /s/ Panna Sharma    
Name:     Panna Sharma
Title:    Chief Executive Officer and President

[Signature page to First Letter Agreement Amending the APA 
to Extend the Closing Deadline]
MIAMI 2997733.4 7933035038Exhibit 4.1

 Exhibit 4.1 
  

					
	NUMBER	 		 	SHARES
	*PRI1*	 	DIGITAL REALTY TRUST, INC.	 	
	THIS CERTIFICATE IS TRANSFERABLE IN NEW YORK, N.Y.	 	INCORPORATED UNDER THE LAWS OF THE STATE OF MARYLAND	 	SEE REVERSE FOR IMPORTANT NOTICE ON TRANSFER RESTRICTIONS AND OTHER INFORMATION
			
		 		 	CUSIP 253868 863

 THIS CERTIFIES THAT 

**SPECIMEN** 
 IS THE OWNER OF  

FULLY PAID AND NONASSESSABLE SHARES OF THE 6.350% SERIES I CUMULATIVE REDEEMABLE PREFERRED STOCK, PAR VALUE $0.01 PER SHARE, OF 

Digital Realty Trust, Inc. 
 (the
“Company”) transferable on the books of the Company by the holder hereof in person or by its duly authorized attorney, upon surrender of this Certificate properly endorsed. This Certificate is not valid unless countersigned by the Transfer
Agent and registered by the Registrar. 
 IN WITNESS WHEREOF, the Company has caused this Certificate to be executed on its behalf by its
duly authorized officers. 
  

							
	DATED                                     
	  		  		  	
				
	Countersigned and Registered:	  	American Stock Transfer & Trust Company, LLC	  		  	
		  	(New York, NY) Transfer Agent and Registrar	  		  	
		  		  		  	                                      
              (SEAL)
		  		  	  
 [Seal]
	  	Chief Financial Officer
	By:                                   
                         	  		  	  

	      Authorized Signature	  		  		  	Senior Vice President, General Counsel and Secretary

 DIGITAL REALTY TRUST, INC. 

IMPORTANT NOTICE 

Classes of Stock 
 THE
COMPANY IS AUTHORIZED TO ISSUE CAPITAL STOCK OF MORE THAN ONE CLASS, CONSISTING OF COMMON STOCK AND ONE OR MORE CLASSES OF PREFERRED STOCK. THE BOARD OF DIRECTORS IS AUTHORIZED TO DETERMINE THE PREFERENCES, LIMITATIONS AND RELATIVE RIGHTS OF ANY
CLASS OF THE PREFERRED STOCK BEFORE THE ISSUANCE OF SHARES OF SUCH CLASS OF PREFERRED STOCK. THE COMPANY WILL FURNISH, WITHOUT CHARGE, TO ANY STOCKHOLDER MAKING A WRITTEN REQUEST THEREFOR, A COPY OF THE COMPANY’S CHARTER AND A WRITTEN STATEMENT
OF THE DESIGNATIONS, RELATIVE RIGHTS, PREFERENCES, CONVERSION OR OTHER RIGHTS, VOTING POWERS, RESTRICTIONS, LIMITATIONS AS TO DIVIDENDS AND OTHER DISTRIBUTIONS, QUALIFICATIONS AND TERMS AND CONDITIONS OF REDEMPTION OF THE STOCK OF EACH CLASS WHICH
THE COMPANY HAS THE AUTHORITY TO ISSUE AND, IF THE COMPANY IS AUTHORIZED TO ISSUE ANY PREFERRED OR SPECIAL CLASS IN SERIES, (i) THE DIFFERENCES IN THE RELATIVE RIGHTS AND PREFERENCES BETWEEN THE SHARES OF EACH SERIES TO THE EXTENT SET, AND
(ii) THE AUTHORITY OF THE BOARD OF DIRECTORS TO SET SUCH RIGHTS AND PREFERENCES OF SUBSEQUENT SERIES. REQUESTS FOR SUCH WRITTEN STATEMENT MAY BE DIRECTED TO THE SECRETARY OF THE COMPANY AT ITS PRINCIPAL OFFICE. 

Restriction on Ownership and Transfer 

THE SHARES OF THE COMPANY’S 6.350% SERIES I CUMULATIVE REDEEMABLE PREFERRED STOCK (“SERIES I PREFERRED STOCK”) REPRESENTED BY
THIS CERTIFICATE ARE SUBJECT TO RESTRICTIONS ON BENEFICIAL AND CONSTRUCTIVE OWNERSHIP AND TRANSFER FOR THE PURPOSE OF THE COMPANY’S MAINTENANCE OF ITS STATUS AS A REAL ESTATE INVESTMENT TRUST UNDER THE INTERNAL REVENUE CODE OF 1986, AS AMENDED
(THE “CODE”). SUBJECT TO CERTAIN FURTHER RESTRICTIONS AND EXCEPT AS EXPRESSLY PROVIDED IN THE ARTICLES SUPPLEMENTARY FOR THE SERIES I PREFERRED STOCK, (i) NO PERSON MAY BENEFICIALLY OR CONSTRUCTIVELY OWN SHARES OF SERIES I PREFERRED
STOCK IN EXCESS OF 9.8% (BY VALUE OR BY NUMBER OF SHARES, WHICHEVER IS MORE RESTRICTIVE) OF THE OUTSTANDING SERIES I PREFERRED STOCK OF THE COMPANY; (ii) NO PERSON MAY BENEFICIALLY OR CONSTRUCTIVELY OWN SHARES OF SERIES I PREFERRED STOCK THAT,
TAKING INTO ACCOUNT ANY OTHER CAPITAL STOCK OF THE COMPANY BENEFICIALLY OR CONSTRUCTIVELY OWNED BY SUCH PERSON, WOULD RESULT IN SUCH PERSON BENEFICIALLY OR CONSTRUCTIVELY OWNING CAPITAL STOCK WITH A VALUE IN EXCESS OF 9.8% OF THE VALUE OF THE
COMPANY’S OUTSTANDING CAPITAL STOCK; (iii) NO PERSON MAY BENEFICIALLY OR CONSTRUCTIVELY OWN SHARES OF SERIES I PREFERRED STOCK THAT, TAKING INTO ACCOUNT ANY OTHER CAPITAL STOCK OF THE COMPANY BENEFICIALLY OR CONSTRUCTIVELY OWNED BY SUCH
PERSON, WOULD RESULT IN THE COMPANY BEING “CLOSELY HELD” UNDER SECTION 856(h) OF THE CODE OR OTHERWISE CAUSE THE COMPANY TO FAIL TO QUALIFY AS A REIT; AND (iv) ANY TRANSFER OF SHARES OF SERIES I PREFERRED STOCK THAT, IF EFFECTIVE,
WOULD RESULT IN THE CAPITAL STOCK OF THE COMPANY BEING BENEFICIALLY OWNED BY FEWER THAN 100 PERSONS WILL BE VOID AB INITIO AND THE INTENDED TRANSFEREE WILL ACQUIRE NO RIGHTS IN SUCH SHARES OF SERIES I PREFERRED STOCK. ANY PERSON WHO BENEFICIALLY OR
CONSTRUCTIVELY OWNS OR ATTEMPTS TO BENEFICIALLY OR CONSTRUCTIVELY OWN SERIES I PREFERRED STOCK WHICH CAUSES OR WILL CAUSE A PERSON TO BENEFICIALLY OR CONSTRUCTIVELY OWN SERIES I PREFERRED STOCK IN EXCESS OF THE ABOVE LIMITATIONS MUST IMMEDIATELY
NOTIFY THE COMPANY. IF ANY OF THE RESTRICTIONS ON TRANSFER OR OWNERSHIP IN (i) THROUGH (iii) ABOVE ARE VIOLATED, THE SERIES I PREFERRED STOCK REPRESENTED HEREBY IN EXCESS OF SUCH RESTRICTIONS WILL BE AUTOMATICALLY TRANSFERRED TO THE
TRUSTEE OF A TRUST FOR THE BENEFIT OF ONE OR MORE CHARITABLE BENEFICIARIES. IN ADDITION, THE COMPANY MAY REDEEM SHARES UPON THE TERMS AND CONDITIONS SPECIFIED BY THE BOARD OF DIRECTORS IN ITS SOLE DISCRETION IF THE BOARD OF DIRECTORS DETERMINES THAT
OWNERSHIP OR A TRANSFER OR OTHER EVENT MAY VIOLATE THE RESTRICTIONS DESCRIBED ABOVE. FURTHERMORE, UPON THE OCCURRENCE OF CERTAIN EVENTS, ATTEMPTED TRANSFERS IN VIOLATION OF THE RESTRICTIONS DESCRIBED ABOVE MAY BE VOID AB INITIO. ALL TERMS IN THIS
LEGEND WHICH ARE DEFINED IN THE ARTICLES SUPPLEMENTARY FOR THE SERIES I PREFERRED STOCK SHALL HAVE THE MEANINGS ASCRIBED TO THEM IN SUCH ARTICLES SUPPLEMENTARY, AS THE SAME MAY BE AMENDED FROM TIME TO TIME, A COPY OF WHICH, INCLUDING THE
RESTRICTIONS ON TRANSFER AND OWNERSHIP, WILL BE FURNISHED TO EACH HOLDER OF SERIES I PREFERRED STOCK ON REQUEST AND WITHOUT CHARGE. REQUESTS FOR SUCH A COPY MAY BE DIRECTED TO THE SECRETARY OF THE COMPANY AT ITS PRINCIPAL OFFICE. 

Keep this Certificate in a safe place. If it is lost, stolen, or destroyed, the Company will require a bond of indemnity as a condition to the issuance of a
replacement certificate. 
 The following abbreviations, when used in the inscription on the face of this certificate, shall be construed as though they
were written out in full according to applicable laws or regulations: 
  

															
		 	TEN COM	  	-	  	as tenants in common	  	UNIF GIFT MIN ACT	  	 	  	Custodian	  	
		 	TEN ENT	  	-	  	as tenants by the entireties	  		  	(Custodian)	  	(Minor)	  	
		 	JT TEN	  	-	  	as joint tenants with right of	  		  	under Uniform Gifts to Minors Act of	  	
		 		  		  	survivorship and not as tenants	  		  	 	  	
		 		  		  	in common	  		  	(State)	  	

 Additional abbreviations may also be used though not in the above list. 

FOR VALUE RECEIVED,
                                         
                                         
                   DOES HEREBY SELL, ASSIGN AND TRANSFER UNTO 
  

	
	 PLEASE INSERT SOCIAL SECURITY OR OTHER

IDENTIFYING NUMBER OF ASSIGNEE

	   

  
  

(Please Print or Typewrite Name and Address, Including Zip Code, of Assignee) 

 
  
  

 
  

 
 shares of the 6.350% Series I Cumulative Redeemable
Preferred Stock represented by the within Certificate and does hereby irrevocably constitute and appoint 
  

 
 to transfer the said stock on the books of the within
named Company with full power of substitution in the premises. 
  

			
	Dated	 	 

  

					
		 	X	  	 
			
		 	X	  	 
			
	Signature(s) Guaranteed	 	NOTICE:	  	THE SIGNATURE TO THIS ASSIGNMENT MUST CORRESPOND WITH THE NAMES AS WRITTEN UPON THE FACE OF THE CERTIFICATE IN EVERY PARTICULAR, WITHOUT ALTERATION OR ENLARGEMENT OR ANY CHANGE WHATEVER.

  
  

					
	By	  	  
	  	
	THE SIGNATURE(S) MUST BE GUARANTEED BY AN ELIGIBLE GUARANTOR INSTITUTION (BANKS, STOCKBROKERS, SAVINGS AND LOAN ASSOCIATIONS AND CREDIT UNIONS WITH MEMBERSHIP IN AN APPROVED SIGNATURE GUARANTEE MEDALLION PROGRAM),
PURSUANT TO S.E.C. RULE 17Ad-15.

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