Document:

EX-4.2

 Exhibit 4.2 

INFRAREDX, INC. 
 NINTH
AMENDED AND RESTATED 
 INVESTOR RIGHTS AGREEMENT 

 INFRAREDX, INC. 

NINTH AMENDED AND RESTATED 
 INVESTOR RIGHTS AGREEMENT 
 THIS NINTH
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT (the “Agreement”) is entered into as of the
             day of November, 2014, by and among INFRAREDX, INC., a Delaware corporation (the “Company”), and the investors
listed on Exhibit A hereto (referred to hereinafter as the “Investors” and each individually as an “Investor”; provided however, that solely for purposes of Sections 1.1 and Section 5
hereof the definition of “Investor” shall include GE Capital Equity Investments, Inc. (“GE”), Solar Capital Ltd. (“Solar”) and Square 1 Bank (“Square 1” and together
with GE and Solar, each a “Lender Warrantholder” and collectively, the “Lender Warrantholders”). 
 RECITALS 
 WHEREAS, the
Company is issuing warrants to purchase shares of the Company’s Series E-1 Preferred Stock (the “Series E-1 Preferred”), pursuant to (i) that certain Second Amended and Restated Loan and Security Agreement dated of
even date herewith by and among the Company, GE and the other parties named therein (the “Loan Agreement”) and (ii) those certain warrants to purchase Series E-1 Preferred issued by the Company to the Lender
Warrantholders pursuant to the Loan Agreement (each, a “Series E-1 Warrant” and collectively, the “Series E-1 Warrants”); 
 WHEREAS, the obligations in the Loan Agreement and the Series E-1 Warrants are conditioned upon the execution and delivery of this Agreement; 

WHEREAS, certain Investors (the “Prior Investors”) and the Company are
parties to the Eighth Amended and Restated Investor Rights Agreement dated July 12, 2013, (the “Prior Agreement”); 
 WHEREAS, the Prior Investors desire to amend and restate the provisions of the Prior Agreement relating to, among other things, registration rights and rights of first
offer and accept the rights and covenants hereof in lieu of their rights and covenants under the Prior Agreement; and 

WHEREAS, in connection with the consummation of the transactions contemplated by the Loan Agreement
and the Series E-1 Warrants, the Company and the Investors have agreed to the registration rights, information rights, and other rights as set forth below. 
 AGREEMENT 
 NOW,
THEREFORE, in consideration of these premises and for other good and valid consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto agree as follows: 

SECTION 1. GENERAL. 
 1.1 Amendment and Restatement of Prior Agreement. The Prior Agreement is hereby amended and restated in its entirety in this Agreement and all provisions of, rights granted and covenants made in
the Prior Agreements are hereby waived, released and superseded in their entirety and shall have no further force or effect, including, without limitation, all rights of first offer (including but not limited to any notice and/or participation
rights with respect to shares of Series E-1 Preferred pursuant to the Series E-1 Warrants), registration rights, information rights and any notice period associated therewith otherwise applicable to the transactions contemplated by the Loan
Agreement, the Series E-1 Warrants and any transactions consummated prior to the date hereof to which such provisions may otherwise have been applicable. 

 1.2 Definitions. As used in this Agreement the following terms shall have the
following respective meanings: 
 (a) “Certificate” shall mean that certain Fifteenth Amended and
Restated Certificate of Incorporation filed with the Delaware Secretary of State on November    , 2014 as amended from time to time. 
 (b) “Common Stock” means the common stock, $0.01 par value per share, of the Company. 
 (c) “Common Warrants” shall mean the warrants to purchase Common Stock issuable or issued to the Investors. 

(d) “Exchange Act” means the Securities Exchange Act of 1934, as amended or any similar federal statute and
the rules and regulations of the SEC thereunder, all as the same shall be in effect at the time. 
 (e) “Form
S-3” means such form under the Securities Act as in effect on the date hereof or any successor or similar registration form under the Securities Act subsequently adopted by the SEC, which permits inclusion or incorporation of
substantial information by reference to other documents filed by the Company with the SEC. 
 (f)
“Holder” means any person owning of record Registrable Securities that have not been sold to the public or any assignee of record of such Registrable Securities in accordance with Section 2.10 hereof and solely for
purposes of Sections 1.1, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 2.10, 2.11, 2.12, 2.13, 2.14 and 2.15 hereof and Section 5 hereof the definition of “Holder” shall include the Lender Warrantholders. 

(g) “Initial Offering” means the Company’s first firm commitment underwritten public offering pursuant
to which the Company’s common stock is listed on a U.S. or foreign exchange. 
 (h) “Lender
Warrants” means those certain warrants to purchase Series E Preferred or Series E-1 Preferred, as the case may be, issued to the Lender Warrantholders, as listed on Exhibit B hereto. 

(i) “Preferred Warrants” shall mean (i) the warrants to purchase shares of Series E Preferred issuable
or issued pursuant to (A) the Series E Preferred Stock and Warrant Purchase Agreement dated as of February 11, 2011 and (B) the Note and Warrant Purchase and Security Agreement dated as of November 27, 2012 and (ii) the
warrants to purchase shares of Series E-1 Preferred Stock issuable or issued pursuant to the Note Purchase Agreement dated as of November    , 2014. 
 (j) “Register,” “registered,” and “registration” refer to a registration effected by preparing and
filing a registration statement in compliance with the Securities Act, and the declaration or ordering of effectiveness of such registration statement or document. 

  
 2. 

 (k) “Registrable Securities” means (i) Common Stock
issuable or issued upon conversion of the Shares, (ii) Common Stock issued to Sanderling Ventures LLC and its affiliates pursuant to that certain Series A Preferred Stock and Common Stock Purchase Agreement dated as of July 21, 2003,
(iii) Common Stock issuable or issued upon exercise of the Common Warrants, (iv) Common Stock issuable or issued upon conversion of the Series E Preferred or Series E-1 Preferred issuable or issued upon exercise of the Preferred Warrants,
(v) any Common Stock issued as (or issuable upon the conversion or exercise of any warrant, right or other security which is issued as) a dividend or other distribution with respect to, or in exchange for or in replacement of, such
above-described securities and (vi) solely for purposes of Sections 1.1, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 2.10, 2.11, 2.12, 2.14 and 2.15 hereof and Section 5 hereof, the Common Stock issued or issuable upon conversion of the
Lender Warrants or any Common Stock issued as (or issuable upon the conversion or exercise of any warrant, right or other security which is issued as) a dividend or other distribution with respect to, or in exchange for or in replacement of, such
above-described securities. Notwithstanding the foregoing, Registrable Securities shall not include (a) any securities sold to the public either pursuant to a registration statement or Rule 144, (b) any securities sold in a private
transaction in which the transferor’s rights under Section 2 of this Agreement are not assigned or (c) any securities held by a Holder (together with its affiliates) if, as reflected on the Company’s list of stockholders, such
Holder (together with its affiliates) holds less than 1% of the Company’s outstanding Common Stock (treating all shares of Preferred Stock on an as converted basis), the Company has completed its Initial Offering and all shares of Common Stock
of the Company issuable or issued upon conversion of the Shares held by and issuable to such Holder (and its affiliates) may be sold pursuant to Rule 144 during any ninety (90) day period. 

(l) “Registrable Securities then outstanding” shall be the number of shares of the Company’s Common
Stock that are Registrable Securities and either (a) are then issued and outstanding or (b) are issuable pursuant to then exercisable or convertible securities. 
 (m) “Registration Expenses” shall mean all expenses incurred by the Company in complying with Sections 2.2, 2.3 and 2.4 hereof, including, without limitation, all
registration and filing fees, printing expenses, fees and disbursements of counsel for the Company, reasonable fees and disbursements not to exceed seventy-five thousand dollars ($75,000) of a single special counsel for the Holders, blue sky fees
and expenses and the expense of any special audits incident to or required by any such registration (but excluding the compensation of regular employees of the Company which shall be paid in any event by the Company). 

(n) “SEC” or “Commission” means the Securities and Exchange Commission. 

(o) “Securities Act” shall mean the Securities Act of 1933, as amended, or any similar federal statute and
the rules and regulations of the SEC thereunder, all as the same shall be in effect at that time. 
 (p)
“Selling Expenses” shall mean all underwriting discounts and selling commissions applicable to the sale of Registrable Securities. 
 (q) “Series A Preferred” shall mean the Company’s Series A Preferred Stock. 
 (r) “Series A-1 Preferred” shall mean the Company’s Series A-1 Preferred Stock. 
 (s) “Series B Preferred” shall mean the Company’s Series B Preferred Stock. 

  
 3. 

 (t) “Series B/B-1 Directors” shall have the meaning ascribed
to it in that certain Tenth Amended and Restated Voting Agreement of even date herewith by and among the Company and the other parties named therein, as amended from time to time. 

(u) “Series B-1 Preferred” shall mean the Company’s Series B-1 Preferred Stock. 

(v) “Series C Preferred” shall mean the Company’s Series C Preferred Stock. 

(w) “Series C-1 Preferred” shall mean the Company’s Series C-1 Preferred Stock. 

(x) “Series D Preferred” shall mean the Company’s Series D Preferred
Stock. 
 (y) “Series D-1 Preferred” shall mean the
Company’s Series D-1 Preferred Stock. 
 (z) “Series E Preferred” shall mean
the Company’s Series E Preferred Stock. 
 (aa) “Shares” shall mean the Series E-1 Preferred,
the Series E Preferred, Series D-1 Preferred, Series D Preferred, Series C-1 Preferred, Series C Preferred, the Series B-1 Preferred, Series B Preferred, Series A Preferred, Series A-1 Preferred and Common Stock held by the Investors listed on
EXHIBIT A hereto and their permitted assigns. 
 (bb) “Special Registration
Statement” shall mean (i) a registration statement relating to any employee benefit plan, (ii) with respect to any corporate reorganization or transaction under Rule 145 of the Securities Act, including any registration
statements related to the issuance or resale of securities issued in such a transaction, or (iii) a registration related to stock issued upon conversion of debt securities. 
 SECTION 2. REGISTRATION; RESTRICTIONS ON TRANSFER. 
 2.1
Restrictions on Transfer. 
 (a) Each Holder agrees not to make any disposition of all or any portion of the
Shares or Registrable Securities unless and until: 
 (i) there is then in effect a registration statement under the
Securities Act covering such proposed disposition and such disposition is made in accordance with such registration statement; or 
 (ii) (A) The transferee has agreed in writing to be bound by the terms of this Agreement, (B) such Holder shall have notified the Company of the proposed disposition and shall have furnished
the Company with a detailed statement of the circumstances surrounding the proposed disposition, and (C) if reasonably requested by the Company, such Holder shall have furnished the Company with an opinion of counsel, reasonably satisfactory to
the Company, that such disposition will not require registration of such shares under the Securities Act and any applicable state securities laws. After its Initial Offering, the Company will not require any transferee pursuant to Rule 144 to be
bound by the terms of this Agreement if the shares so transferred do not remain Registrable Securities hereunder following such transfer. 

  
 4. 

 (b) Notwithstanding the provisions of section 2.1(a) above, no opinion of counsel
shall be required for a transfer by a Holder that is (A) a partnership transferring to its partners or former partners in accordance with partnership interests, (B) a corporation transferring to a wholly-owned subsidiary or a parent
corporation that owns all of the capital stock of the Holder, (C) a limited liability company transferring to its members or former members in accordance with their interest in the limited liability company, or (D) an individual
transferring to the Holder’s family member or trust for the benefit of an individual Holder; provided that in each case the transferee (i) will agree in writing to be subject to the terms of this Agreement to the same extent as if
he were an original Holder hereunder, and (ii) executes and delivers to the Company a representation letter in form reasonably satisfactory to the Company’s counsel to the effect that the transferee is acquiring such shares for its own
account, for investment purposes and without a view to distribution or resale thereof. 
 (c) Each certificate
representing Shares or Registrable Securities shall be stamped or otherwise imprinted with legends substantially similar to the following (in addition to any legend required under applicable state securities laws): 

THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933 (THE “ACT”) OR THE APPLICABLE
SECURITIES LAWS AND REGULATIONS OF CANADA, AND MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED, ASSIGNED, PLEDGED OR HYPOTHECATED UNLESS AND UNTIL REGISTERED UNDER THE ACT OR UNLESS THE COMPANY HAS RECEIVED AN OPINION OF COUNSEL SATISFACTORY TO
THE COMPANY AND ITS COUNSEL THAT SUCH REGISTRATION IS NOT REQUIRED. 
 THE SALE, PLEDGE, HYPOTHECATION OR TRANSFER OF THE
SECURITIES REPRESENTED BY THIS CERTIFICATE IS SUBJECT TO THE TERMS AND CONDITIONS OF A CERTAIN INVESTOR RIGHTS AGREEMENT BY AND BETWEEN THE STOCKHOLDER AND THE COMPANY. COPIES OF SUCH AGREEMENT MAY BE OBTAINED UPON WRITTEN REQUEST TO THE SECRETARY
OF THE COMPANY. 
 With respect to Canadian residents: 
 UNLESS PERMITTED UNDER SECURITIES LEGISLATION, THE HOLDER OF THE SECURITY MUST NOT TRADE THE SECURITY BEFORE THE DATE THAT IS FOUR MONTHS AND A DAY AFTER THE LATER OF: (I) OCTOBER 7, 2010; AND (II)
THE DATE THE ISSUER BECOMES A REPORTING ISSUER IN ANY PROVINCE OR TERRITORY. 
 (d) The Company shall be obligated to
reissue promptly unlegended certificates at the request of any Holder thereof if the Company has completed its Initial Offering and the Holder shall have obtained an opinion of counsel (which counsel may be counsel to the Company) reasonably
acceptable to the Company to the effect that the securities proposed to be disposed of may lawfully be so disposed of without registration under the Securities Act and any applicable state securities laws, qualification and legend. 

  
 5. 

 (e) Any legend endorsed on an instrument pursuant to applicable state securities laws
and the stop-transfer instructions with respect to such securities shall be removed upon receipt by the Company of an order of the appropriate blue sky authority authorizing such removal. 

2.2 Demand Registration. 
 (a) Subject to the conditions of this Section 2.2, if the Company shall receive a written request from the Holders of a majority of the Registrable Securities (the “Initiating
Holders”) that the Company file a registration statement under the Securities Act or comparable document filed with a foreign securities commission or regulatory authority covering the registration of at least fifty percent
(50%) of the Registrable Securities then outstanding (or a lesser percentage if the proposed aggregate offering price, net of underwriting discounts and commissions, would exceed $5,000,000), then the Company shall, within thirty (30) days
of the receipt thereof, give written notice of such request to all Holders, and subject to the limitations of this Section 2.2, effect, as expeditiously as reasonably possible, the registration under the Securities Act or pursuant to a receipt
issued for a final prospectus by the applicable securities commission or regulatory authority in a foreign jurisdiction of all Registrable Securities that all Holders request to be registered. 

(b) If the Initiating Holders intend to distribute the Registrable Securities covered by their request by means of an underwriting,
they shall so advise the Company as a part of their request made pursuant to this Section 2.2 or any request pursuant to Section 2.4 and the Company shall include such information in the written notice referred to in Section 2.2(a) or
Section 2.4(a), as applicable. In such event, the right of any Holder to include its Registrable Securities in such registration shall be conditioned upon such Holder’s participation in such underwriting and the inclusion of such
Holder’s Registrable Securities in the underwriting to the extent provided herein. All Holders proposing to distribute their securities through such underwriting shall (together with the Company as provided in Section 2.6(e)) enter into an
underwriting agreement in customary form with the underwriter or underwriters mutually selected for such underwriting by the Company and a majority in interest of the Initiating Holders. Notwithstanding any other provision of this Section 2.2
or Section 2.4, if the underwriter advises the Company that marketing factors require a limitation of the number of securities to be underwritten (including Registrable Securities) then the Company shall so advise all Holders of Registrable
Securities which would otherwise be underwritten pursuant hereto, and the number of shares that may be included in the underwriting shall be allocated to the Holders of such Registrable Securities on a pro rata basis based on the number of
Registrable Securities held by all such Holders (including the Initiating Holders); provided, however, that the number of shares of Registrable Securities to be included in such underwriting and registration shall not be reduced unless
all other securities are first entirely excluded from the underwriting and registration. Any Registrable Securities excluded or withdrawn from such underwriting shall be withdrawn from the registration. Except as otherwise provided in this
Section 2.2(b), the Company shall be entitled to include in any registration statement referred to in this Section 2.2 shares of Common Stock to be sold by the Company for its own account. 

(c) The Company shall not be required to effect a registration pursuant to this Section 2.2: 

(i) prior to the earlier of (A) the second anniversary of the date of this Agreement or (B) one hundred eighty
(180) days following the effective date of the registration statement pertaining to the Initial Offering; 

  
 6. 

 (ii) after the Company has effected two (2) registrations pursuant to this
Section 2.2, and such registrations have been declared or ordered effective; 
 (iii) during the period starting
with the date of filing of, and ending on the date one hundred eighty (180) days following the effective date of the registration statement pertaining to the Initial Offering; provided that the Company makes reasonable good faith efforts
to cause such registration statement to become effective; 
 (iv) if within thirty (30) days of receipt of a written
request from the Initiating Holders pursuant to Section 2.2(a), the Company gives notice to the Holders of the Company’s intention to file a registration statement for its Initial Offering within ninety (90) days of the date of such
request; 
 (v) if, within thirty (30) days of receipt of a written request from the Initiating Holders pursuant to
Section 2.2(a), the Company shall furnish to the Holders requesting a registration statement pursuant to this Section 2.2, a certificate signed by the Chairman of the Board stating that in the good faith judgment of the Board of Directors
of the Company, such registration would reasonably be expected to have a material adverse effect on the Company and its stockholders, in which event the Company shall have the right to defer such filing for a period of not more than ninety
(90) days after receipt of the request of the Initiating Holders; provided that such right to delay a request shall be exercised by the Company not more than once in any twelve (12) month period; 

(vi) if the Initiating Holders propose to dispose of shares of Registrable Securities that may be immediately registered on Form
S-3 pursuant to a request made pursuant to Section 2.4 below; or 
 (vii) in any particular jurisdiction in which
the Company would be required to qualify to do business or to execute a general consent to service of process in effecting such registration, qualification or compliance. 
 2.3 Piggyback Registrations. The Company shall notify all Holders of Registrable Securities in writing at least fifteen (15) business days prior to the filing of any registration statement
under the Securities Act or pursuant to a receipt issued for a final prospectus by the applicable securities commission or regulatory authority in a foreign jurisdiction for purposes of a public offering of securities of the Company (including, but
not limited to, registration statements relating to secondary offerings of securities of the Company, but excluding Special Registration Statements and registration statements proposed to be filed pursuant to Section 2.2 and Section 2.4
hereof) and will afford each such Holder an opportunity to include in such registration statement all or part of such Registrable Securities held by such Holder. Each Holder desiring to include in any such registration statement all or any part of
the Registrable Securities held by it shall, within fifteen (15) business days after the above-described notice from the Company, so notify the Company in writing. Such notice shall state the intended number of shares of Registrable Securities
proposed by such Holder to be included in the registration statement. If a Holder decides not to include all of its Registrable Securities in any registration statement thereafter filed by the Company, such Holder shall nevertheless continue to have
the right to include any Registrable Securities in any subsequent registration statement or registration statements as may be filed by the Company with respect to offerings of its securities, all upon the terms and conditions set forth herein.

  
 7. 

 (a) Underwriting. If the registration statement under which the Company gives notice
under this Section 2.3 is for an underwritten offering, the Company shall so advise the Holders of Registrable Securities. In such event, the right of any such Holder to be included in a registration pursuant to this Section 2.3 shall be
conditioned upon such Holder’s participation in such underwriting and the inclusion of such Holder’s Registrable Securities in the underwriting to the extent provided herein. All Holders proposing to distribute their Registrable Securities
through such underwriting shall enter into an underwriting agreement in customary form with the underwriter or underwriters selected for such underwriting by the Company. Notwithstanding any other provision of this Agreement, if the underwriter
determines in good faith that marketing factors require a limitation of the number of shares to be underwritten, the number of shares that may be included in the underwriting shall be allocated, first, to the Company; second, to the Holders on a
pro rata basis based on the total number of Registrable Securities held by the Holders; and third, to any stockholder of the Company (other than a Holder) on a pro rata basis; provided, however, that no such reduction
shall reduce the amount of securities of the selling Holders included in the registration below thirty percent (30%) of the total amount of securities included in such registration, unless such offering is the Initial Offering and such
registration does not include shares of any other selling stockholders, in which event any or all of the Registrable Securities of the Holders may be excluded in accordance with the immediately preceding clause. In no event will shares of any other
selling stockholder be included in such registration that would reduce the number of shares, which may be included by Holders without the written consent of Holders of not less than a majority of the Registrable Securities proposed to be sold in the
offering. If any Holder disapproves of the terms of any such underwriting, such Holder may elect to withdraw therefrom by written notice to the Company and the underwriter, delivered at least ten (10) business days prior to the effective date
of the registration statement. Any Registrable Securities excluded or withdrawn from such underwriting shall be excluded and withdrawn from the registration. For any Holder which is a partnership or corporation, the partners, retired partners and
stockholders of such Holder, or the estates and family members of any such partners and retired partners and any trusts for the benefit of any of the foregoing person shall be deemed to be a single “Holder,” and any pro rata
reduction with respect to such “Holder” shall be based upon the aggregate amount of shares carrying registration rights owned by all entities and individuals included in such “Holder,” as defined in this sentence. 

(b) Right to Terminate Registration. The Company shall have the right to terminate or withdraw any registration initiated by it
under this Section 2.3 prior to the effectiveness of such registration whether or not any Holder has elected to include securities in such registration. The Registration Expenses of such withdrawn registration shall be borne by the Company in
accordance with Section 2.5 hereof. 
 2.4 Form S-3 Registration. In case the Company shall receive from any Holder
or Holders of Registrable Securities a written request or requests that the Company effect a registration on Form S-3 or any similar short-form registration statement and any related qualification or compliance with respect to all or a part of the
Registrable Securities owned by such Holder or Holders, the Company will: 
 (a) promptly give written notice of the
proposed registration, and any related qualification or compliance, to all other Holders of Registrable Securities; and 
 (b)
as soon as practicable, effect such registration and all such qualifications and compliances as may be so requested and as would permit or facilitate the sale and distribution of all or such portion of such Holder’s or Holders’
Registrable Securities as are specified in such request, together with all or such portion of the Registrable Securities of any other Holder or Holders joining in such request as are specified in a written request given within fifteen (15) days
after receipt of such written notice from the Company; provided, however, that the Company shall not be obligated to effect any such registration, qualification or compliance pursuant to this Section 2.4: 

(i) if Form S-3 is not available for such offering by the Holders, 

  
 8. 

 (ii) if the Holders propose to sell Registrable Securities and such other securities
(if any) at an aggregate price to the public of less than Five Hundred Thousand Dollars ($500,000), 
 (iii) if within
thirty (30) days of receipt of a written request from any Holder or Holders pursuant to this Section 2.4, the Company gives notice to such Holder or Holders of the Company’s intention to make a public offering within ninety
(90) days, other than pursuant to a Special Registration Statement; 
 (iv) if the Company shall furnish to the
Holders a certificate signed by the Chairman of the Board of Directors of the Company stating that in the good faith judgment of the Board of Directors of the Company, such registration would reasonably be expected to have a material adverse effect
on the Company and its stockholders, in which event the Company shall have the right to defer the filing of the Form S-3 registration statement for a period of not more than one hundred twenty (120) days after receipt of the request of the
Holder or Holders under this Section 2.4; provided, however, that such right to delay a request shall be exercised by the Company not more than twice in any twelve (12) month period, 

(v) if the Company has, within the twelve (12) month period preceding the date of such request, already effected two
(2) registrations on Form S-3 for the Holders pursuant to this Section 2.4, or 
 (vi) in any particular
jurisdiction in which the Company would be required to qualify to do business or to execute a general consent to service of process in effecting such registration, qualification or compliance. 

(c) subject to the foregoing, the Company shall file a Form S-3 registration statement covering the Registrable Securities and
other securities so requested to be registered as soon as practicable after receipt of the request from the requisite Holders. Registrations effected pursuant to this Section 2.4 shall not be counted as demands for registration or registrations
effected pursuant to Section 2.2. If the registration statement filed pursuant to this Section 2.4 is for an underwritten offering, each of the procedures and requirements of Section 2.2(b) shall apply to such registration.

 2.5 Expenses of Registration. Except as specifically provided herein, all Registration Expenses incurred in connection
with any registration, qualification or compliance pursuant to Section 2.2 or any registration under Section 2.3 or Section 2.4 herein shall be borne by the Company. All Selling Expenses incurred in connection with any registrations
hereunder, shall be borne by the holders of the securities so registered pro rata on the basis of the number of shares so registered. The Company shall not, however, be required to pay for expenses of any registration proceeding begun
pursuant to Section 2.2 or 2.4, the request of which has been subsequently withdrawn by the Initiating Holders unless (a) the withdrawal is based upon material adverse information concerning the Company of which the Initiating Holders were
not aware at the time of such request or (b) the Holders of a majority of Registrable Securities agree to forfeit their right to one requested registration pursuant to Section 2.2 or Section 2.4, as applicable, in which event such
right shall be forfeited by all Holders). If the Holders are required to pay the Registration Expenses, such expenses shall be borne by the holders of securities (including Registrable Securities) requesting such registration in proportion to the
number of shares for which registration was requested. If the Company is required to pay the Registration Expenses of a withdrawn offering pursuant to clause (a) above, then the Holders shall not forfeit their rights pursuant to
Section 2.2 or Section 2.4 to a demand registration. 

  
 9. 

 2.6 Obligations of the Company. Whenever required to effect the registration of any
Registrable Securities, the Company shall, as expeditiously as reasonably possible: 
 (a) Prepare and file with the SEC a
registration statement with respect to such Registrable Securities and use all reasonable efforts to cause such registration statement to become effective, and, upon the request of the Holders of a majority of the Registrable Securities registered
thereunder, keep such registration statement effective for up to ninety (90) days or, if earlier, until the Holder or Holders have completed the distribution related thereto; provided, however, that at any time, upon written
notice to the participating Holders and for a period not to exceed ninety (90) days thereafter (the “Suspension Period”), the Company may delay the filing or effectiveness of any registration statement or suspend the use
or effectiveness of any registration statement (and the Holders hereby agree not to offer or sell any Registrable Securities pursuant to such registration statement during the Suspension Period) if the Company reasonably believes that the Company
may, in the absence of such delay or suspension hereunder, be required under state or federal securities laws to disclose any material non-public information that, in the reasonable opinion of the Company, should not be disclosed. No more than one
(1) such Suspension Period shall occur in any twelve (12) month period. In the event that the Company shall exercise its right to delay or suspend the filing or effectiveness of a registration hereunder, the applicable time period during
which the registration statement is to remain effective shall be extended by a period of time equal to the duration of the Suspension Period. The Company may extend the Suspension Period for an additional consecutive sixty (60) days with the
consent of the Holders of a majority of the Registrable Securities registered under such registration statement. If so directed by the Company, all Holders registering shares under such registration statement shall use their best efforts to deliver
to the Company (at the Company’s expense) all copies, other than permanent file copies then in such Holders’ possession, of the prospectus relating to such Registrable Securities current at the time of receipt of such notice. 

(b) Prepare and file with the SEC (or a foreign securities commission or regulatory authority) such amendments and supplements to
such registration statement and the prospectus used in connection with such registration statement as may be necessary to comply with the provisions of the Securities Act or applicable law with respect to the disposition of all securities covered by
such registration statement for the period set forth in subsection (a) above. 
 (c) Furnish to all Holders
registering shares under the registration statement such number of copies of a prospectus, including a preliminary prospectus, in conformity with the requirements of the Securities Act or applicable law, and such other documents as they may
reasonably request in order to facilitate the disposition of the Registrable Securities covered by the registration statement. 

(d) Use its reasonable efforts to register and qualify the securities covered by such registration statement under such other
securities or Blue Sky laws of such jurisdictions as shall be reasonably requested by all Holders registering shares under such registration statement; provided that the Company shall not be required in connection therewith or as a condition
thereto to qualify to do business or to file a general consent to service of process in any such states or jurisdictions. 

(e) In the event of any underwritten public offering, enter into and perform its obligations under an underwriting agreement, in
usual and customary form, with the managing underwriter(s) of such offering. Each Holder participating in such underwriting shall also enter into and perform its obligations under such an agreement. 

  
 10.

 (f) Notify each Holder of Registrable Securities covered by such registration
statement at any time when a prospectus relating thereto is required to be delivered under the Securities Act or applicable law of the happening of any event of which the Company has knowledge and as a result of which the prospectus included in such
registration statement, as then in effect, includes an untrue statement of a material fact or omits to state a material fact required to be stated therein or necessary to make the statements therein not misleading in the light of the circumstances
then existing. The Company will use reasonable efforts to amend or supplement such prospectus in order to cause such prospectus not to include any untrue statement of a material fact or omit to state a material fact required to be stated therein or
necessary to make the statements therein not misleading in the light of the circumstances then existing. 
 (g) Use its
reasonable efforts to furnish, on the date that such Registrable Securities are delivered to the underwriters for sale, if such securities are being sold through underwriters, (i) an opinion, dated as of such date, of the counsel representing
the Company for the purposes of such registration, in form and substance as is customarily given to underwriters in an underwritten public offering, addressed to the underwriters, if any, and (ii) a letter, dated as of such date, from the
independent certified public accountants of the Company, in form and substance as is customarily given by independent certified public accountants to underwriters in an underwritten public offering addressed to the underwriters. 

2.7 Termination of Registration Rights. All registration rights granted under this Section 2 shall terminate and be of no
further force and effect five (5) years after the date of the Company’s Initial Offering. 
 2.8 Delay of
Registration; Furnishing Information. 
 (a) No Holder shall have any right to obtain or seek an injunction
restraining or otherwise delaying any such registration as the result of any controversy that might arise with respect to the interpretation or implementation of this Section 2. 

(b) It shall be a condition precedent to the obligations of the Company to take any action pursuant to Section 2.2, 2.3 or 2.4
that the selling Holders shall furnish to the Company in writing such information regarding themselves, the Registrable Securities held by them and the intended method of disposition of such securities as shall be required to effect the registration
of their Registrable Securities. 
 (c) The Company shall have no obligation with respect to any registration requested
pursuant to Section 2.2 or Section 2.4 if, due to the operation of subsection 2.2(b), the number of shares or the anticipated aggregate offering price of the Registrable Securities to be included in the registration does not equal or
exceed the number of shares or the anticipated aggregate offering price required to originally trigger the Company’s obligation to initiate such registration as specified in Section 2.2 or Section 2.4, whichever is applicable.

 2.9 Indemnification. In the event any Registrable Securities are included in a registration statement under Sections
2.2, 2.3 or 2.4: 
 (a) To the extent permitted by law, the Company will indemnify and hold harmless each Holder, the
partners, members, officers and directors of each Holder, any underwriter (as defined in the Securities Act) for such Holder and each person, if any, who controls such Holder or underwriter within the meaning of the Securities Act or the Exchange
Act, against any losses, claims, damages, or liabilities (joint or several) to which they may become subject under the Securities Act, the Exchange Act or other federal or state law, insofar as such losses, claims, damages or liabilities (or actions
in respect thereof) arise out of or are based upon any of the following statements, omissions or violations 

  
 11.

 
(collectively a “Violation”) by the Company: (i) any untrue statement or alleged untrue statement of a material fact contained in such registration statement or
incorporated by reference therein, including any preliminary prospectus or final prospectus contained therein or any amendments or supplements thereto, (ii) the omission or alleged omission to state therein a material fact required to be stated
therein, or necessary to make the statements therein not misleading, or (iii) any violation or alleged violation by the Company of the Securities Act, the Exchange Act, any state securities law, any foreign securities laws or any rule or
regulation promulgated under the Securities Act, the Exchange Act, any state securities law or any foreign securities laws in connection with the offering covered by such registration statement; and the Company will reimburse each such Holder,
partner, member, officer, director, underwriter or controlling person for any legal or other expenses reasonably incurred by them in connection with investigating or defending any such loss, claim, damage, liability or action; provided
however, that the indemnity agreement contained in this Section 2.9(a) shall not apply to amounts paid in settlement of any such loss, claim, damage, liability or action if such settlement is effected without the consent of the Company,
which consent shall not be unreasonably withheld, nor shall the Company be liable in any such case for any such loss, claim, damage, liability or action to the extent that it arises out of or is based upon a Violation which occurs in reliance upon
and in conformity with written information furnished expressly for use in connection with such registration by such Holder, partner, member, officer, director, underwriter or controlling person of such Holder. 

(b) To the extent permitted by law, each Holder will, severally and not jointly, if Registrable Securities held by such Holder are
included in the securities as to which such registration qualifications or compliance is being effected, indemnify and hold harmless the Company, each of its directors, its officers and each person, if any, who controls the Company within the
meaning of the Securities Act, any underwriter and any other Holder selling securities under such registration statement or any of such other Holder’s partners, directors or officers or any person who controls such Holder, against any losses,
claims, damages or liabilities (joint or several) to which the Company or any such director, officer, controlling person, underwriter or other such Holder, or partner, director, officer or controlling person of such other Holder may become subject
under the Securities Act, the Exchange Act or other federal, state or foreign law, insofar as such losses, claims, damages or liabilities (or actions in respect thereto) arise out of or are based upon any of the following statements: (i) any
untrue statement or alleged untrue statement of a material fact contained in such registration statement or incorporated reference therein, including any preliminary prospectus or final prospectus contained therein or any amendments or supplements
thereto, (ii) the omission or alleged omission to state therein a material fact required to be stated therein, or necessary to make the statements therein not misleading, or (iii) any violation or alleged violation by the Company of the
Securities Act, the Exchange Act, any state securities law, or any foreign securities laws or rule or regulation promulgated under any state or foreign securities law in connection with the offering covered by the registration statement
(collectively, a “Holder Violation”), in each case to the extent (and only to the extent) that such Holder Violation occurs in reliance upon and in conformity with written information furnished by such Holder and stated to be
specifically for use in connection with such registration; and each such Holder will reimburse any legal or other expenses reasonably incurred by the Company or any such director, officer, controlling person, underwriter or other Holder, or partner,
officer, director or controlling person of such other Holder in connection with investigating or defending any such loss, claim, damage, liability or action; provided, however, that the indemnity agreement contained in this
Section 2.9(b) shall not apply to amounts paid in settlement of any such loss, claim, damage, liability or action if such settlement is effected without the consent of the Holder, which consent shall not be unreasonably withheld; provided
further, that in no event shall any indemnity under this Section 2.9 (x) exceed the net proceeds from the offering received by such Holder or (y) with respect to the Lender Warrantholders only, include any claim for punitive
damages. 

  
 12.

 (c) Promptly after receipt by an indemnified party under this Section 2.9 of
notice of the commencement of any action (including any governmental action), such indemnified party will, if a claim in respect thereof is to be made against any indemnifying party under this Section 2.9, deliver to the indemnifying party a
written notice of the commencement thereof and the indemnifying party shall have the right to participate in, and, to the extent the indemnifying party so desires, jointly with any other indemnifying party similarly noticed, to assume the defense
thereof with counsel mutually satisfactory to the parties; provided, however, that an indemnified party shall have the right to retain its own counsel, with the fees and expenses to be paid by the indemnifying party, if representation
of such indemnified party by the counsel retained by the indemnifying party would be inappropriate due to actual or potential differing interests between such indemnified party and any other party represented by such counsel in such proceeding. The
failure to deliver written notice to the indemnifying party within a reasonable time of the commencement of any such action, if materially prejudicial to its ability to defend such action, shall relieve such indemnifying party of any liability to
the indemnified party under this Section 2.9, but the omission to so deliver written notice to the indemnifying party will not relieve it of any liability that it may have to any indemnified party otherwise than under this Section 2.9.

 (d) If the indemnification provided for in this Section 2.9 is held by a court of competent jurisdiction to be
unavailable to an indemnified party with respect to any losses, claims, damages or liabilities referred to herein, the indemnifying party, in lieu of indemnifying such indemnified party thereunder, shall to the extent permitted by applicable law
contribute to the amount paid or payable by such indemnified party as a result of such loss, claim, damage or liability in such proportion as is appropriate to reflect the relative fault of the indemnifying party on the one hand and of the
indemnified party on the other in connection with the Violation(s) or Holder Violation(s) that resulted in such loss, claim, damage or liability, as well as any other relevant equitable considerations. The relative fault of the indemnifying party
and of the indemnified party shall be determined by a court of law by reference to, among other things, whether the untrue or alleged untrue statement of a material fact or the omission to state a material fact relates to information supplied by the
indemnifying party or by the indemnified party and the parties’ relative intent, knowledge, access to information and opportunity to correct or prevent such statement or omission; provided, that in no event shall any contribution by a
Holder hereunder exceed the net proceeds from the offering received by such Holder; provided, further, however, that no person or entity guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the
Securities Act) will be entitled to contribution from any person or entity who was not guilty of such fraudulent misrepresentation. 
 (e) The obligations of the Company and Holders under this Section 2.9 shall survive completion of any offering of Registrable Securities in a registration statement and the termination of this
Agreement. No indemnifying party, in the defense of any such claim or litigation, shall, except with the consent of each indemnified party, consent to entry of any judgment or enter into any settlement which does not include as an unconditional term
thereof the giving by the claimant or plaintiff to such indemnified party of a release from all liability in respect to such claim or litigation. 
 2.10 Assignment of Registration Rights. The rights to cause the Company to register Registrable Securities pursuant to this Section 2 may be transferred or assigned by a Holder to a transferee
or assignee of Registrable Securities that (a) is a subsidiary, parent, general partner, limited partner, retired partner, member or retired member, or stockholder of a Holder, (b) is a Holder’s family member or trust for the benefit
of an individual Holder, or (c) acquires at least sixty six percent (66%) of the Registrable Securities (as adjusted for stock splits and combinations) originally held by the assigning or transferring Holder; or (d) is an entity
affiliated by common control (or other related entity) with such Holder; provided, however, in each instance (i) the transferor shall, within ten (10) days after such transfer, furnish to the Company written notice of the
name and address of such transferee or assignee and the securities with respect to which such registration rights are being assigned and (ii) such transferee shall agree in writing to be subject to all restrictions set forth in this Agreement.

  
 13.

 2.11 Amendment of Registration Rights. Any provision of this Section 2 may be
amended and the observance thereof may be waived (either generally or in a particular instance and either retroactively or prospectively), only with the written consent of the Company and the Holders of at least a majority of the Registrable
Securities then outstanding. Any amendment or waiver effected in accordance with this Section 2.11 shall be binding upon each Holder and the Company. By acceptance of any benefits under this Section 2, Holders of Registrable Securities
hereby agree to be bound by the provisions hereunder. 
 2.12 Limitation on Subsequent Registration Rights. Other than as
provided in Section 5.10, after the date of this Agreement, the Company shall not, without the prior written consent of the Holders of at least a majority of the Registrable Securities then outstanding, enter into any agreement with any holder
or prospective holder of any securities of the Company that would grant such holder registration rights on a parity with or senior to those granted to the Holders hereunder other than the right to a Special Registration Statement; provided,
however, that the Company may grant to a third party piggy-back registration rights provided that such grants are approved by the Board of Directors of the Company including the approval at least one of the Series B/B-1 Directors. 

2.13 “Market Stand-Off” Agreement. Each Holder hereby agrees that such Holder shall not sell, transfer,
make any short sale of, grant any option for the purchase of, or enter into any hedging or similar transaction with the same economic effect as a sale, any Common Stock (or other securities) of the Company held by such Holder (other than those
included in the registration) for a period specified by the representative of the underwriters of Common Stock (or other securities) of the Company during the one hundred eighty (180) day period following the effective date of a registration
statement of the Company filed under the Securities Act or pursuant to a receipt issued for a final prospectus by the applicable securities commissions or regulatory authorities in a foreign jurisdiction (or such longer period as the underwriters or
the Company shall reasonably request in order to facilitate compliance with FINRA Rule 2711 or NYSE Member Rule 472 or any successor or similar rule or regulation); provided that: 

(i) such agreement shall apply only to the Company’s Initial Offering; and 

(ii) all officers and directors of the Company and holders of at least one percent (1%) of the Company’s voting
securities enter into similar agreements; provided, however, that in the event the Company or the underwriter gives its prior written consent to permit any Holder to be released from the restrictions set forth in this Section 2.13
(a “Released Holder”), then each other Holder shall be entitled to a pro rata release of such Holder’s securities of the Company in the same percentage as the total number of securities of the Company that the
Company or the underwriter, as the case may be, permits to be released bears to the total number of securities of the Company owned by the Released Holder. 
 2.14 Agreement to Furnish Information. Each Holder agrees to execute and deliver such other agreements as may be reasonably requested by the Company or the underwriter that are consistent with the
Holder’s obligations under Section 2.13 or that are necessary to give further effect thereto. In addition, if requested by the Company or the representative of the underwriters of Common Stock (or other securities) of the Company, each
Holder shall provide, within ten (10) days of such request, such information as may be required by the Company or such representative in connection with the completion of any public offering of the Company’s securities pursuant to a
registration statement filed under the Securities Act or pursuant to a receipt issued for a final prospectus by the applicable securities commissions or regulatory authorities in a foreign jurisdiction. The obligations described in Section 2.13

  
 14.

 
and this Section 2.14 shall not apply to a Special Registration Statement. The Company may impose stop-transfer instructions with respect to the shares of Common Stock (or other securities)
subject to the foregoing restriction until the end of said one hundred eighty (180) day period (or such longer period as the underwriters or the Company shall reasonably request in order to facilitate compliance with FINRA Rule 2711 or NYSE
Member Rule 472 or any successor or similar rule or regulation). Each Holder agrees that any transferee of any shares of Registrable Securities shall be bound by Sections 2.13 and 2.14. The underwriters of the Company’s stock are intended third
party beneficiaries of Sections 2.13 and 2.14 and shall have the right, power and authority to enforce the provisions hereof as though they were a party hereto. 
 2.15 Rule 144 Reporting. With a view to making available to the Holders the benefits of certain rules and regulations of the SEC which may permit the sale of the Registrable Securities to the
public without registration, at all times after the effective date of the first registration filed by the Company for an offering of its securities to the general public, the Company agrees to use its best efforts to: 

(a) Make and keep public information available, as those terms are understood and defined in SEC Rule 144 or any similar or
analogous rule promulgated under the Securities Act or required by any applicable foreign securities commissions or regulatory authorities; 
 (b) File with the SEC, in a timely manner, all reports and other documents required of the Company under the Exchange Act or required by any applicable foreign securities commissions or regulatory
authorities; and 
 (c) So long as a Holder owns any Registrable Securities, furnish to such Holder forthwith upon
request: a written statement by the Company as to its compliance with the reporting requirements of said Rule 144 of the Securities Act, and of the Exchange Act (at any time after it has become subject to such reporting requirements); a copy of the
most recent annual or quarterly report of the Company filed with the Commission; and such other reports and documents as a Holder may reasonably request in connection with availing itself of any rule or regulation of the SEC or any applicable
foreign securities commissions or regulatory authorities allowing it to sell any such securities without registration. 
 SECTION 3.
COVENANTS OF THE COMPANY. 
 3.1 Basic Financial Information and Reporting. 

(a) The Company will maintain true books and records of account in which full and correct entries will be made of all its business
transactions pursuant to a system of accounting established and administered in accordance with generally accepted accounting principles consistently applied (except as noted therein), and will set aside on its books all such proper accruals and
reserves as shall be required under generally accepted accounting principles consistently applied. 
 (b) To the extent
requested by an Investor, as soon as practicable after the end of each fiscal year of the Company, and in any event within ninety (90) days thereafter (or within such longer period as is approved by the Company’s Board of Directors), the
Company will furnish such Investor a balance sheet of the Company, as of the end of such fiscal year, and a statement of operations and a statement of cash flows of the Company, for such year, all prepared in accordance with generally accepted
accounting principles consistently applied (except as noted therein or as disclosed to the recipients thereof) and setting forth in each case in comparative form the figures for the previous fiscal year, all in reasonable detail. Such financial
statements shall be accompanied by a report and opinion thereon by independent public accountants standing selected by the Company’s Board of Directors. 

  
 15.

 (c) So long as an Investor (together with its affiliates) shall own not less than one
million (1,000,000) shares of Registrable Securities (as adjusted for stock splits, combinations and similar transactions) (a “Major Investor”), the Company will furnish each such Major Investor as soon as practicable
after the end of each quarter, and in any event within forty five (45) days thereafter (or within such longer period as is approved by the Company’s Board of Directors), a balance sheet of the Company as of the end of each such quarter,
and a statement of operations and a statement of cash flows of the Company for such quarter and for the current fiscal year to date, prepared in accordance with generally accepted accounting principles consistently applied (except as noted thereon),
with the exception that no notes need be attached to such statements. 
 3.2 Inspection Rights. Each Major Investor shall
have, upon three (3) business days’ notice and during regular business hours, the right to visit and inspect any of the properties of the Company or any of its subsidiaries, and to discuss the affairs, finances and accounts of the Company
or any of its subsidiaries with its officers, and to review such information as is reasonably requested all at such reasonable times and as often as may be reasonably requested; provided, however, that each Major Investor agrees to
keep all information disclosed to such Major Investor confidential in accordance with Section 3.3 hereof; provided further, however that the Company shall not be obligated under this Section 3.2 with respect to a competitor
of the Company or with respect to information which the Board of Directors determines in good faith is confidential or attorney-client privileged and should not, therefore, be disclosed. 

3.3 Confidentiality of Records. Each Investor agrees to use, and to use the same degree of care as such Investor uses to protect
its own confidential information, but in no event less than commercially reasonable efforts, to keep confidential any information furnished to that Investor that is confidential or proprietary (so long as such information is not in the public
domain), except that such Investor may disclose such proprietary or confidential information (i) to any partner, subsidiary or parent of such Investor for the purpose of evaluating its investment in the Company as long as such partner,
subsidiary or parent is advised of the confidentiality provisions of this Section 3.3 and the Investor instructs the recipient to treat the information as confidential; (ii) at such time as it enters the public domain through no fault of
such Investor; or (iii) that is communicated to it free of any obligation of confidentiality. 
 3.4 Reservation of
Common Stock. The Company will at all times reserve and keep available, solely for issuance and delivery upon the conversion of the Preferred Stock, all Common Stock issuable from time to time upon such conversion. 

3.5 Stock Vesting. Unless otherwise approved by the Board of Directors, all stock options and other stock equivalents issued after
the date of this Agreement to employees, directors, consultants and other service providers shall be subject to vesting as follows: (a) twenty-five percent (25%) of such stock shall vest at the end of the first year following the earlier
of the date of issuance or such person’s services commencement date with the Company, and (b) seventy-five percent (75%) of such stock shall vest pro rata on a monthly basis over the remaining three (3) years. With respect
to any shares of stock purchased by any such person, the Company’s repurchase option shall provide that upon such person’s termination of employment or service with the Company, with or without cause, the Company or its assignee shall have
the option to purchase at cost any unvested shares of stock held by such person. 

  
 16.

 3.6 Proprietary Information and Inventions Agreement. Unless otherwise approved by
the Board of Directors, the Company shall require all employees and consultants to execute and deliver a Proprietary Information and Inventions Agreement substantially in a form approved by the Company’s counsel. 

3.7 Approval. The Company shall not without the approval of a majority of the Board of Directors, with all non-interested Directors
voting and the approval at least one of the Series B/B-1 Directors, authorize or enter into any transactions with any director or management employee, or such director’s or employee’s immediate family. 

3.8 Directors’ Liability and Indemnification. The Certificate and Bylaws shall provide (a) for elimination of the
liability of director to the maximum extent permitted by law, and (b) for indemnification of directors for acts on behalf of the Company to the maximum extent permitted by law. 

3.9 Termination of Covenants. All covenants of the Company contained in Section 3 of this Agreement (other than the provisions
of Section 3.3) shall expire and terminate as to each Investor upon the effective date of the registration statement pertaining to the Initial Offering. 
 SECTION 4. RIGHTS OF FIRST OFFER. 
 4.1 Subsequent
Offerings. Subject to applicable securities laws, each Major Investor shall have a right of first offer to purchase its pro rata share of all Equity Securities, as defined below, that the Company may, from time to time, propose to sell
and issue after the date of this Agreement, other than the Equity Securities excluded by Section 4.6 hereof. Each Investor’s pro rata share is equal to a fraction (a) the numerator of which is the number of shares of the
Company’s Common Stock (including all shares of Common Stock issuable or issued upon conversion of the Shares or upon exercise of any outstanding security convertible into or exercisable or exchangeable for, with or without consideration, any
Common Stock, Preferred Stock or other security (including any option or warrant to purchase such convertible security) of the Company) which such Investor is deemed to be a holder immediately prior to the issuance of such Equity Securities, and
(b) the denominator of which is the total number of shares of the Company’s outstanding Common Stock (including all shares of Common Stock issued or issuable upon conversion of the Shares or upon the exercise of any outstanding security
convertible into or exercisable or exchangeable for, with or without consideration, any Common Stock, Preferred Stock or other security (including any option or warrant to purchase such a convertible security) of the Company) immediately prior to
the issuance of the Equity Securities. The term “Equity Securities” shall mean (i) any Common Stock, Preferred Stock or other security of the Company, (ii) any security convertible into or exercisable or
exchangeable for, with or without consideration, any Common Stock, Preferred Stock or other equity security (including any option or warrant to purchase such a convertible security), (iii) any equity security carrying any warrant or right to
subscribe to or purchase any Common Stock, Preferred Stock or other equity security or (iv) any such warrant or right. 

4.2 Exercise of Rights. If the Company proposes to issue any Equity Securities, it shall give each Major Investor written notice of
its intention, describing the Equity Securities, the price and the terms and conditions upon which the Company proposes to issue the same. Each Major Investor shall have fifteen (15) business days from the giving of such notice to agree to
purchase its pro rata share of the Equity Securities for the price and upon the terms and conditions specified in the notice by giving written notice to the Company and stating therein the quantity of Equity Securities to be purchased.
Notwithstanding the foregoing, the Company shall not be required to offer or sell such Equity Securities to any Major Investor who would cause the Company to be in violation of applicable federal securities laws by virtue of such offer or sale.

  
 17.

 4.3 Issuance of Equity Securities to Other Persons. If not all of the Major Investors
elect to purchase their full pro rata share of the Equity Securities, then the Company shall promptly notify in writing each Major Investor who does so elect to purchase such Major Investor’s full pro rata share and shall offer
each such Major Investor the right to acquire such unsubscribed shares. The Major Investors shall have fifteen (15) business days after receipt of such notice to notify the Company of its election to purchase all or a portion thereof of the
unsubscribed shares. The Company shall have ninety (90) days thereafter to sell the Equity Securities in respect of which the Major Investor’s rights were not exercised, at a price and upon general terms and conditions materially no more
favorable to the purchasers thereof than specified in the Company’s notice to the Major Investors pursuant to Section 4.2 hereof. If the Company has not sold such Equity Securities within ninety (90) days of the expiration of the
aforementioned fifteen (15) business day period, the Company shall not thereafter issue or sell any Equity Securities, without first offering such securities to the Major Investors in the manner provided above. 

4.4 Termination and Waiver of Rights of First Offer. The rights of first offer established by this Section 4 shall not apply
to, and shall terminate upon the effective date of the registration statement pertaining to the Company’s Initial Offering. The rights of first offer established by this Section 4 may be amended, or any provision waived with the written
consent of Major Investors holding a majority of the Registrable Securities held by all Major Investors, and any amendment or waiver pursuant to this Section 4.4 shall be binding on all Major Investors, even if any of such Major Investors do
not execute such waiver and regardless of whether one or more Major Investors participates in the purchase of the Equity Securities offered pursuant to this Section 4. 
 4.5 Transfer of Rights of First Offer. The rights of first offer of each Major Investor under this Section 4 may be transferred or assigned by a Major Investor to a transferee or assignee that
(a) is a subsidiary, parent, general partner, limited partner, retired partner, member or retired member, or stockholder of such Major Investor, (b) is a Major Investor’s family member or trust for the benefit of a Major Investor,
(c) acquires at least sixty six percent (66%) of the Registrable Securities (as adjusted for stock splits and combinations) originally held by the assigning or transferring Major Investor; or (d) is an entity affiliated by common
control (or other related entity) with such Major Investor; provided, however, in each instance (i) the transferor shall, within ten (10) days after such transfer, furnish to the Company written notice of the name and address
of such transferee or assignee and the securities with respect to which such registration rights are being assigned and (ii) such transferee shall agree in writing to be subject to all restrictions set forth in this Agreement. 

4.6 Excluded Securities. The rights of first offer established by this Section 4 shall have no application to securities of
the Company issued or issuable: 
 (a) upon conversion of the Preferred Stock; 

(b) to employees, officers or directors of, or consultants or advisors to the Company or any subsidiary pursuant to stock purchase
or stock option plans or other arrangements that are approved by the Board of Directors; 
 (c) pursuant to the exercise
of options, warrants, notes or other rights to acquire securities of the Company outstanding as of the date hereof and securities issued pursuant to any such options, warrants, notes or other rights to acquire securities of the Company granted after
the date hereof, so long as the rights of first refusal established by this Section 4 were complied with, waived, or were inapplicable pursuant to any provision of this Section 4.6 with respect to the initial issuance or grant of such
options, warrants, notes or other rights to acquire securities of the Company; 
 (d) for consideration other than cash
pursuant to a merger, consolidation, acquisition, purchase of all or substantially all of an entity’s stock or assets or similar business combination approved by the Board of Directors; 

  
 18.

 (e) pursuant to any equipment loan or leasing arrangement, real property leasing
arrangement or debt financing from a bank or similar financial institution approved by the Board of Directors; 
 (f) to
third-party service providers in exchange for or as partial consideration for services rendered to the Company approved by the Board of Directors; 
 (g) for non-capital raising purposes in connection with strategic transactions involving the Company and other entities, including (i) joint ventures, strategic alliances, manufacturing,
marketing or distribution arrangements, or (ii) technology transfer or development arrangements; provided that the issuance of shares therein has been approved by the Board of Directors; 

(h) in connection with any stock split, stock dividend or recapitalization by the Company or other similar event; 

(i) pursuant to the Purchase Agreement; or 
 (j) by the Company in an underwritten public offering pursuant to a registration statement filed under the Securities Act or pursuant to a receipt issued for a final prospectus by the applicable
securities commissions or regulatory authorities in a foreign jurisdiction. 
 SECTION 5. MISCELLANEOUS. 

5.1 Governing Law. This Agreement shall be governed by and construed under the laws of the State of Delaware in all respects as
such laws are applied to agreements among Delaware residents entered into and to be performed entirely within Delaware. The parties agree that any action brought by either party under or in relation to this Agreement, including without limitation to
interpret or enforce any provision of this Agreement, shall be brought in, and each party agrees to and does hereby submit to the jurisdiction and venue of, any state or federal court located in the County of Suffolk, Massachusetts. 

5.2 Successors and Assigns. Except as otherwise expressly provided herein, the provisions hereof shall inure to the benefit of, and
be binding upon, the parties hereto and their respective successors, assigns, heirs, executors, and administrators and shall inure to the benefit of and be enforceable by each person who shall be a holder of Registrable Securities from time to time;
provided, however, that prior to the receipt by the Company of adequate written notice of the transfer of any Registrable Securities specifying the full name and address of the transferee, the Company may deem and treat the person
listed as the holder of such shares in its records as the absolute owner and holder of such shares for all purposes. 
 5.3
Entire Agreement. This Agreement, the Exhibits and Schedules hereto, the Purchase Agreement and the other documents delivered pursuant thereto constitute the full and entire understanding and agreement between the parties with regard to the
subjects hereof and does hereby supersede all other agreements of the parties relating to the subject matter hereof, including without limitation, the Prior Agreements. No party shall be liable or bound to any other in any manner by any oral or
written representations, warranties, covenants and agreements except as specifically set forth herein and therein. 
 5.4
Severability. In the event one or more of the provisions or part of a provision of this Agreement should, for any reason, be held to be invalid, illegal or unenforceable in any respect, such invalidity, illegality, or unenforceability shall not
affect any other provision or part of a provision of this Agreement, and this Agreement shall be construed as if such invalid, illegal or unenforceable provision had never been contained herein. 

  
 19.

 5.5 Amendment and Waiver. 

(a) Except as otherwise expressly provided, this Agreement may be amended or modified only upon the written consent of the Company
and the Holders of at least a majority of the then-outstanding Registrable Securities. 
 (b) Except as otherwise
expressly provided, the obligations of the Company and the rights of the Holders under this Agreement may be waived only with the written consent of the Holders of at least a majority of the then-outstanding Registrable Securities. 

(c) For the purposes of determining the number of Holders or Investors entitled to vote or exercise any rights hereunder, the
Company shall be entitled to rely solely on the list of record holders of its stock as maintained by or on behalf of the Company. 
 (d) Notwithstanding any other provision of this Section 5.5, the Company without the consent of any Investor, may amend EXHIBIT A solely for the purposes of providing any
necessary information regarding any transferee or assignee of any Investor. 
 5.6 Delays or Omissions. It is agreed that
no delay or omission to exercise any right, power, or remedy accruing to any party, upon any breach, default or noncompliance by another party under this Agreement shall impair any such right, power, or remedy, nor shall it be construed to be a
waiver of any such breach, default or noncompliance, or any acquiescence therein, or of any similar breach, default or noncompliance thereafter occurring. It is further agreed that any waiver, permit, consent, or approval of any kind or character on
any party’s part of any breach, default or noncompliance under the Agreement or any waiver on such party’s part of any provisions or conditions of this Agreement must be in writing and shall be effective only to the extent specifically set
forth in such writing. All remedies, either under this Agreement, by law, or otherwise afforded to any party, shall be cumulative and not alternative. 
 5.7 Notices. All notices required or permitted hereunder shall be in writing and shall be deemed effectively given: (a) upon personal delivery to the party to be notified, (b) when sent
by confirmed electronic mail or facsimile if sent during normal business hours of the recipient; if not, then on the next business day, (c) five (5) days after having been sent by registered or certified mail, return receipt requested,
postage prepaid, or (d) one (1) day after deposit with a nationally recognized overnight courier, specifying next day delivery, with written verification of receipt. All communications shall be sent to the Company at its address listed on
the signature page hereto (with a copy to its counsel (which shall not constitute notice) at: Nicole Brookshire, Esq., Cooley LLP, 500 Boylston Street, 14th Floor, Boston, MA 02116) or to any Investor at the last address provided in writing to the Company in accordance with
this Section 5.7 or, with respect to the Company, at such other address as the Company may designate by ten (10) days advance written notice to the other parties hereto in accordance with this Section 5.7. 

5.8 Attorneys’ Fees. In the event that any suit or action is instituted under or in relation to this Agreement, including
without limitation to enforce any provision in this Agreement, the prevailing party in such dispute shall be entitled to recover from the losing party all fees, costs and expenses of enforcing any right of such prevailing party under or with respect
to this Agreement, including without limitation, such reasonable fees and expenses of attorneys and accountants, which shall include, without limitation, all fees, costs and expenses of appeals. 

  
 20.

 5.9 Titles and Subtitles. The titles of the sections and subsections of this
Agreement are for convenience of reference only and are not to be considered in construing this Agreement. 
 5.10
[Intentionally Omitted] 
 5.11 Counterparts; Facsimile. This Agreement may be executed by signing an Omnibus
Financing Document Signature Page of even date herewith, which may be executed in any number of counterparts and which may be executed and delivered by facsimile or .PDF signature, each of which shall be an original, but all of which together shall
constitute one instrument. 
 5.12 Aggregation of Stock. All shares of Registrable Securities held or acquired by
affiliated entities or persons or persons or entities under common management or control shall be aggregated together for the purpose of determining the availability of any rights under this Agreement. 

5.13 Pronouns. All pronouns contained herein, and any variations thereof, shall be deemed to refer to the masculine, feminine or
neutral, singular or plural, as to the identity of the parties hereto may require. 
 5.14 Termination. This Agreement
shall terminate and be of no further force or effect upon the earlier of (i) immediately prior to the closing of an Acquisition or Asset Transfer (each, as defined in the Certificate); or (ii) the date five (5) years following the
closing of the Initial Offering. 
 [THIS SPACE INTENTIONALLY LEFT
BLANK] 

  
 21.

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above
written. 
  

			
	COMPANY:
	
	INFRAREDX, INC.
		
	By:	 	 /s/ Donald Southard

	Name:	 	Donald Southard
	Title:	 	Chief Executive Officer

  
 Signature
Page to Ninth Amended and Restated Investor Rights Agreement of 
 Infraredx, Inc. 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above
written. 
  

			
	INVESTOR:
	
	NIPRO CORPORATION
		
	By:	 	 /s/ Yoshihiko Sano

	Name: Yoshihiko Sano
	Title (if applicable): President and Representative Director

  
 Signature
Page to Ninth Amended and Restated Investor Rights Agreement of 
 Infraredx, Inc. 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above written. 

 

							
		 		 	INVESTORS:
			
	Dated: October 28, 2014	 		 	SANDERLING VENTURE PARTNERS V, L.P.
		 		 	By:	 	Middleton, McNeil & Mills Associates V, LLC
				
		 		 	By:	 	 /s/ Robert G. McNeil

		 		 		 	Robert G. McNeil
		 		 		 	Managing Director
			
	Dated: October 28, 2014	 		 	SANDERLING V BIOMEDICAL, L.P.
		 		 	By:	 	Middleton, McNeil & Mills Associates V, LLC
				
		 		 	By:	 	 /s/ Robert G. McNeil

		 		 		 	Robert G. McNeil
		 		 		 	Managing Director
			
	Dated: October 28, 2014	 		 	SANDERLING V LIMITED PARTNERSHIP
		 		 	By:	 	Middleton, McNeil & Mills Associates V, LLC
				
		 		 	By:	 	 /s/ Robert G. McNeil

		 		 		 	Robert G. McNeil
		 		 		 	Managing Director
			
	Dated: October 28, 2014	 		 	SANDERLING V BETEILIGUNGS GMBH & CO. KG
		 		 	By:	 	Middleton, McNeil & Mills Associates V, LLC
				
		 		 	By:	 	 /s/ Robert G. McNeil

		 		 		 	Robert G. McNeil
		 		 		 	Managing Director

							
	Dated: October 28, 2014	 		 	SANDERLING VENTURES MANAGEMENT V
				
		 		 	By:	 	 /s/ Robert G. McNeil

		 		 		 	Robert G. McNeil
		 		 		 	Managing Director
			
	Dated: October 28, 2014	 		 	SANDERLING V STRATEGIC EXIT FUND, L.P.
		 		 	By:	 	Middleton, McNeil & Mills Associates V, LLC
				
		 		 	By:	 	 /s/ Robert G. McNeil

		 		 		 	Robert G. McNeil
		 		 		 	Managing Director
			
	Dated: October 28, 2014	 		 	SANDERLING VENTURE PARTNERS V CO-INVESTMENT FUND,
L.P.
		 		 	By:	 	Middleton, McNeil & Mills Associates V, LLC
				
		 		 	By:	 	 /s/ Robert G. McNeil

		 		 		 	Robert G. McNeil
		 		 		 	Managing Director
			
	Dated: October 28, 2014	 		 	SANDERLING V BIOMEDICAL CO-INVESTMENT FUND, L.P.
		 		 	By:	 	Middleton, McNeil & Mills Associates V, LLC
				
		 		 	By:	 	 /s/ Robert G. McNeil

		 		 		 	Robert G. McNeil
		 		 		 	Managing Director
			
	Dated: October 28, 2014	 		 	SANDERLING VENTURE PARTNERS VI CO-INVESTMENT FUND, L.P.
		 		 	By:	 	Middleton, McNeil, Mills & Associates VI, LLC
				
		 		 	By:	 	 /s/ Robert G. McNeil

		 		 		 	Robert G. McNeil
		 		 		 	Managing Director

							
	Dated: October 28, 2014	 		 	SANDERLING VI LIMITED PARTNERSHIP
		 		 	By:	 	Middleton, McNeil, Mills & Associates VI, LLC
				
		 		 	By:  	 	/s/ Robert G. McNeil
		 		 		 	Robert G. McNeil
		 		 		 	Managing Director
			
	Dated: October 28, 2014	 		 	SANDERLING VI BETEILIGUNGS GMBH & CO. KG
		 		 	By:	 	Middleton, McNeil, Mills & Associates VI, LLC
				
		 		 	By:	 	/s/ Robert G. McNeil
		 		 		 	Robert G. McNeil
		 		 		 	Managing Director
			
	Dated: October 28, 2014	 		 	SANDERLING VENTURES MANAGEMENT VI
				
		 		 	By:	 	/s/ Robert G. McNeil
		 		 		 	Robert G. McNeil
		 		 		 	Managing Director
			
	Dated: October 28, 2014	 		 	SANDERLING VENTURE PARTNERS V CO-INVESTMENT FUND, L.P.
		 		 	By:	 	Middleton, McNeil & Mills Associates V, LLC
				
		 		 	By:	 	/s/ Robert G. McNeil
		 		 		 	Robert G. McNeil
		 		 		 	Managing Director

			
	SANDERLING VENTURE PARTNERS VI 
CO-INVESTMENT FUND, L.P.
	By: Middleton, McNeil, Mills & Associates VI, LLC
		
	By:	 	/s/ Robert G. McNeil
		 	Robert G. McNeil
		 	Managing Director
	
	MIDDLETON-MCNEIL RETIREMENT TRUST
	FBO: ROBERT G MCNEIL PHD
		
	By:	 	/s/ Robert G. McNeil
		 	Robert G. McNeil
		 	Trustee

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above
written. 
  

			
	INVESTOR:
	
	LITHIUM INVESTMENTS LLC
		
	 By:
	 	/s/ Greg Litton
	 Name: Greg Litton

	 Title (if applicable): Manager

 Signature Page to Ninth Amended and Restated Investor Rights Agreement of 

Infraredx, Inc. 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above
written. 
  

			
	INVESTOR:
	
	SEAHAWK INVESTMENT TRUST
		
	 By:
	 	/s/ Kenneth G. Jones
	 Name: Kenneth G. Jones

	 Title (if applicable): Trustee

  
 Signature
Page to Ninth Amended and Restated Investor Rights Agreement of 
 Infraredx, Inc. 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above
written. 
  

			
	INVESTOR:
	
	INTREPID MARITIME, LLC
		
	By:	 	/s/ Mark Filanowski
	Name: Mark Filanowski
	Title (if applicable): Vice President

  
 Signature
Page to Ninth Amended and Restated Investor Rights Agreement of 
 Infraredx, Inc. 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above
written. 
  

			
	INVESTOR:
	
	EASTWOOD CAPITAL CORP.
		
	By:	 	/s/ William Holland
	Name: William Holland
	Title (if applicable): President & Director

  
 Signature
Page to Ninth Amended and Restated Investor Rights Agreement of 
 Infraredx, Inc. 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above
written. 
  

	
	INVESTOR:
	
	BLACK MOUNTAIN VENTURES LLC
	
	By: /s/ Greg
Litton                                       
                            
	Name: Greg Litton
	Title (if applicable): Manager

  
 Signature
Page to Ninth Amended and Restated Investor Rights Agreement of 
 Infraredx, Inc. 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above
written. 
  

	
	 INVESTOR:

	
	 By: /s/ Mark
Filanowski                                      
                  

	 Name: Mark Filanowski

	 Title (if
applicable):                                       
                         

  
 Signature
Page to Ninth Amended and Restated Investor Rights Agreement of 
 Infraredx, Inc. 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above
written. 
  

	
	INVESTOR:
	
	By: /s/ William W.
Priest                                       
               
	Name: William W. Priest
	Title (if
applicable):                                       
                         

  

	
	 Signed on behalf of:

	 Priest Family Trust

	 William W Priest

	 William W. Priest IRA #2

  
 Signature
Page to Ninth Amended and Restated Investor Rights Agreement of 
 Infraredx, Inc. 

 EXHIBIT A 
 SCHEDULE OF INVESTORS 
  

	
	 562 Mission Street, LLC

	
	 Jayvee & Co. A/C MFYF7020002 ITF Keystone Equity Fund

	
	 Jayvee & Co. A/C INVF0042002 IG AGF Canadian Growth Fund

	
	 Jayvee & Co. A/C IFTAF0014002 ITF IG AGF Canadian Growth Class

	
	 Peter Anderson

	
	 Emily F. Baker

	
	 Bershaw & Co. A/C #6015782001 ITF AGF Canadian Stock Fund

	
	 Black Mountain Ventures LLC

	
	 Robert H. Bluestein

	
	 Suzanne Bluestein

	
	 Bluestein Capital Opportunity Fund

	
	 Hilary J. Boone, Jr.

	
	 Katherine Bristor

	
	 Patricia Reed Bristor IRA R/O Dated 3/16/01

	
	 James C. Butler

	
	 Carol Anne Levy Revocable Trust

	
	 Anne Castine

	
	 Michael Castine

	
	 Leon I. Charash, M.D.

	
	 William E. Charash, M.D., Ph.D.

	
	 Edward J. Conner

	
	 Elizabeth Dater

	
	 David C. Cox Trust UAD 12/15/83

	
	 Richard B. Denning

	
	 Robert M. Dewey, Jr.

	
	 Gregg Diliberto

	
	 Linda Dresner

	
	 Eastwood Capital. Corp.

	
	 Mark Filanowski

	
	 Peter A. Flaherty

	
	 Elena A. Ford

	
	 Richard Foster

	
	 Orrie M. Friedman, Ph.D.

	
	 G. Raymond Chang Ltd.

	
	 Pierre Gloutney

	
	 GMP Securuties L.P. IFG 2118278 Ontario Limited

	
	 GMP Securities L.P. ITF Larry Ullman

  
 A-1

	
	 GMP Securities L.P. ITF Richard Pilosof

	
	 GMP Securities L.P. ITF Genesis Partners Fund LP

	
	 James A. Goldstein Trust dated August 2, 1994

	
	 James A. Goldstein Irrevocable Exempt Trust dated May 23, 2005

	
	 Cynthia D. Goldstein Irrevocable Exempt Trust dated August 18, 2005

	
	 Cynthia D. Goldsteint Trust dated August 2, 1994

	
	 Uschi Graham, M.D.

	
	 Michael Gramegna

	
	 Derek Jeffrey Green

	
	 Michael E. & Mary Guarasci, Sr.

	
	 Michael E. Guarasci, Sr.

	
	 Harmir Realty Co.

	
	 Harmir Realty Co. (Account # 063-45980)

	
	 K. Carter Harris

	
	 James Hintlian

	
	 Hoffman Family Trust

	
	 Georges L. Holzberger

	
	 Intrepid Maritime LLC

	
	 Douglas Jamieson

	
	 Kevin K. Keady

	
	 John F. Kehoe

	
	 Roger Keller

	
	 Michael Kelly

	
	 Kettle Family L.P.

	
	 Eric Lager, M.D.

	
	 Edward C. Levy, Jr.

	
	 Ellen Levy

	
	 Richard Lindquist

	
	 Robert Lodder, Ph.D.

	
	 Ian Madill

	
	 Margaret T. Marquard Grantor Retained Annuity Trust

	
	 Marquard Family Partnership Ltd.

	
	 William A. Marquard QTIP Trust

	
	 William A. Marguard

	
	 Alfred Martinelli

	
	 David McBain

	
	 John J. McGarty

	
	 Daniel McNulty

	
	 MedVenture Technology Corporation

	
	 Michael H. Klein Revocable Trust

	
	 Middleton-McNeil Retirement Trust FBO: Robert G. McNeil PhD.

  
 A-2

	
	 Pedro Moreno, M.D.

	
	 James E. Muller, M.D.

	
	 Paul F. Muller Living Trust dated September 25, 1997

	
	 Lawrence P. Mulligan, Trustee, u/a/d 10/31/2001

	
	 William O’Brien

	
	 William O’Connor, M.D.

	
	 The Osterweis Revocable Trust u/a dated 9/13/93, John S. Osterweis, Trustee

	
	 David C. Pauli

	
	 Marie Pauli

	
	 David Y. Phelps

	
	 Priest Family Trust

	
	 William W. Priest

	
	 William W. Priest IRA #2

	
	 MLPF&S as Cust. FBO William W. Priest

	
	 Quantel Financial Corporation

	
	 Roger Reinlieb

	
	 Gary D. Rose and Karen A. Rose, Jt. Ten.

	
	 Barbara Aaron Rosston

	
	 The Rosston Family Revocable Trust u/a dtd 9/22/94, John W. Rosston & Barbara H. Rosston, Trustees

	
	 Steven J. Rosston

	
	 Alfredo Rodriguez, M.D., Ph.D.

	
	 SAMCO Partners (Account # 063-62155)

	
	 SAMCO Partners LP

	
	 Sanderling V Beteiligungs GmbH & Co. KG

	
	 Sanderling V Biomedical, L.P.

	
	 Sanderling V Biomedical Co-Investment, L.P.

	
	 Sanderling V Limited Partnership

	
	 Sanderling Venture Partners V, L.P.

	
	 Sanderling Venture Partners V Co-Investment, L.P.

	
	 Sanderling Ventures Management V

	
	 Sanderling Venture Partners VI Co-Investment, L.P.

	
	 Sanderling Ventures Management VI

	
	 Sanderling VI Beteiligungs GmbH & Co. KG

	
	 Sanderling VI Limited Partnership

	
	 Sheila Scott

	
	 Seahawk Investment Trust

	
	 Mark & Heidi Silverstein

	
	 Laurence Smith

	
	 Gavin Steinberg

	
	 Justin Steinberg

  
 A-3

	
	 Profit Sharing Trust F/B/O Michael Steinberg

	
	 Somu Subramaniam

	
	 Timothy T. Taussig

	
	 Jeremy Teo

	
	 University of Kentucky Research Foundation

	
	 Urban Associates

	
	 Venglo Capital SA

	
	 Richard W. Watt

	
	 Lynn Wilhelm

	
	 C.R. Wilson

	
	 W. David Wood

	
	 Douglas M. Wynyard Living Trust

	
	 Bessemer Trust Company of Florida as Trustee of the 2009 Alan J. Zakon Annuity Trust Lithium Investments LLC

	
	 Nipro Corporation

  
 A-4

 EXHIBIT B 
 SCHEDULE OF LENDER WARRANTS 
  

					
	 Holder
	  	 Date of Issuance
	  	 Number and Type of Shares underlying
Lender
Warrant

			
	 GE Capital Equity Investments, Inc.
	  	October 6, 2011	  	483,871 shares of Series E Preferred
			
	 GE Capital Equity Investments, Inc.
	  	September 20, 2013	  	544,355 shares of Series E Preferred
			
	 Square 1 Bank
	  	September 20, 2013	  	181,452 shares of Series E Preferred
			
	 GE Capital Equity Investments, Inc.
	  	November    , 2014	  	1,125,000 shares of Series E-1 Preferred
			
	 Solar Capital Ltd
	  	November    , 2014	  	749,925 shares of Series E-1 Preferred
			
	 Square 1 Bank
	  	November    , 2014	  	375,075 shares of Series E-1 Preferred

  
 B-1

							
	 SECTION 1.
	 	GENERAL	  	 	1	  
			
	 1.1
	 	Amendment and Restatement of Prior Agreement	  	 	1	  
			
	 1.2
	 	Definitions	  	 	2	  
			
	 SECTION 2.
	 	REGISTRATION; RESTRICTIONS ON TRANSFER	  	 	4	  
			
	 2.1
	 	Restrictions on Transfer	  	 	4	  
			
	 2.2
	 	Demand Registration	  	 	6	  
			
	 2.3
	 	Piggyback Registrations	  	 	7	  
			
	 2.4
	 	Form S-3 Registration	  	 	8	  
			
	 2.5
	 	Expenses of Registration	  	 	9	  
			
	 2.6
	 	Obligations of the Company	  	 	10	  
			
	 2.7
	 	Termination of Registration Rights	  	 	11	  
			
	 2.8
	 	Delay of Registration; Furnishing Information	  	 	11	  
			
	 2.9
	 	Indemnification	  	 	11	  
			
	 2.10
	 	Assignment of Registration Rights	  	 	13	  
			
	 2.11
	 	Amendment of Registration Rights	  	 	14	  
			
	 2.12
	 	Limitation on Subsequent Registration Rights	  	 	14	  
			
	 2.13
	 	“Market Stand-Off” Agreement	  	 	14	  
			
	 2.14
	 	Agreement to Furnish Information	  	 	14	  
			
	 2.15
	 	Rule 144 Reporting	  	 	15	  
			
	 SECTION 3.
	 	COVENANTS OF THE COMPANY	  	 	15	  
			
	 3.1
	 	Basic Financial Information and Reporting	  	 	15	  
			
	 3.2
	 	Inspection Rights	  	 	16	  
			
	 3.3
	 	Confidentiality of Records	  	 	16	  
			
	 3.4
	 	Reservation of Common Stock	  	 	16	  
			
	 3.5
	 	Stock Vesting	  	 	16	  
			
	 3.6
	 	Proprietary Information and Inventions Agreement	  	 	17	  
			
	 3.7
	 	Approval	  	 	17	  
			
	 3.8
	 	Directors’ Liability and Indemnification	  	 	17	  
			
	 3.9
	 	Termination of Covenants	  	 	17	  
			
	 SECTION 4.
	 	RIGHTS OF FIRST OFFER	  	 	17	  
			
	 4.1
	 	Subsequent Offerings	  	 	17	  
			
	 4.2
	 	Exercise of Rights	  	 	17	  
			
	 4.3
	 	Issuance of Equity Securities to Other Persons	  	 	18	  
			
	 4.4
	 	Termination and Waiver of Rights of First Offer	  	 	18	  
			
	 4.5
	 	Transfer of Rights of First Offer	  	 	18	  
			
	 4.6
	 	Excluded Securities	  	 	18	  

  
 i 

							
			
	 SECTION 5.
	 	MISCELLANEOUS	  	 	19	  
			
	 5.1
	 	Governing Law	  	 	19	  
			
	 5.2
	 	Successors and Assigns	  	 	19	  
			
	 5.3
	 	Entire Agreement	  	 	19	  
			
	 5.4
	 	Severability	  	 	19	  
			
	 5.5
	 	Amendment and Waiver	  	 	20	  
			
	 5.6
	 	Delays or Omissions	  	 	20	  
			
	 5.7
	 	Notices	  	 	20	  
			
	 5.8
	 	Attorneys’ Fees	  	 	20	  
			
	 5.9
	 	Titles and Subtitles	  	 	21	  
			
	 5.10
	 	Counterparts	  	 	21	  
			
	 5.11
	 	Aggregation of Stock	  	 	21	  
			
	 5.12
	 	Pronouns	  	 	21	  
			
	 5.13
	 	Termination	  	 	21	  

  
 iiEX-10.1

 Exhibit 10.1 

NORTHWEST PARK 
 LEASE

 BY AND BETWEEN 

THE TRUSTEES OF N.W. BUILDING 18 TRUST 

(AS LANDLORD) 
 AND

 INFRAREDX, INC. 

(AS TENANT) 
 FOR
PREMISES 
 AT 
 34
THIRD AVENUE 
 BURLINGTON, MASSACHUSETTS 

 TABLE OF CONTENTS 

 

							
	 TABLE OF CONTENTS
	  	 	2	  
		
	 ARTICLE 1 REFERENCE DATA
	  	 	4	  
		
	 1.1       SUBJECT REFERRED TO
	  	 	4	  
	 1.2       EXHIBITS
	  	 	5	  
		
	 ARTICLE 2 PREMISES AND TERM
	  	 	6	  
		
	 2.1       PREMISES
	  	 	6	  
	 2.2       TERM
	  	 	6	  
	 2.3       EXTENSION OPTION
	  	 	6	  
	 2.4       ZONING CONTINGENCY
	  	 	7	  
		
	 ARTICLE 3 CONDITION OF PREMISES
	  	 	7	  
		
	 ARTICLE 4 RENT
	  	 	7	  
		
	 4.1       THE FIXED RENT
	  	 	7	  
	 4.2       ADDITIONAL RENT
	  	 	7	  
	 4.2.1
	 	Real Estate Taxes	  	 	7	  
	 4.2.2
	 	Personal Property Taxes	  	 	8	  
	 4.2.3
	 	Operating Costs	  	 	8	  
	 4.2.4
	 	Insurance	  	 	9	  
	 4.2.5
	 	Utilities	  	 	10	  
	 4.3       LATE PAYMENT OF
RENT
	  	 	10	  
	 4.4       LETTER OF CREDIT
	  	 	10	  
	 4.4.1
	 	Amount of Letter of Credit.	  	 	10	  
	 4.4.2
	 	Renewal of Letter of Credit	  	 	10	  
	 4.4.3
	 	Draws to Cure Defaults.	  	 	10	  
	 4.4.4
	 	Draws to Pay Damages.	  	 	11	  
	 4.4.5
	 	Draws for Failure to Deliver Substitute Letter of Credit	  	 	11	  
	 4.4.6
	 	Transferability	  	 	11	  
	 4.4.7
	 	Return of Letter of Credit at End of Term	  	 	11	  
		
	 ARTICLE 5 LANDLORD’S COVENANTS
	  	 	11	  
		
	 5.1       AFFIRMATIVE COVENANTS
	  	 	11	  
	 5.1.1
	 	Heat and Air-Conditioning	  	 	11	  
	 5.1.2
	 	Electricity	  	 	11	  
	 5.1.3
	 	Water.	  	 	11	  
	 5.1.4
	 	Elevator; Fire Alar	  	 	11	  
	 5.1.5
	 	Repairs	  	 	11	  
	 5.2       INTERRUPTION
	  	 	11	  
	 5.4       OUTSIDE SERVICES
	  	 	12	  
	 5.5       ACCESS
	  	 	12	  
	 5.6       LANDLORD’S INSURANCE
	  	 	12	  
		
	 ARTICLE 6 TENANT’S ADDITIONAL COVENANTS
	  	 	12	  
		
	 6.1       AFFIRMATIVE COVENANTS
	  	 	12	  
	 6.1.1
	 	Perform Obligations	  	 	12	  
	 6.1.2
	 	Use	  	 	12	  
	 6.1.3
	 	Repair and Maintenance	  	 	12	  
	 6.1.4
	 	Compliance with Law	  	 	13	  
	 6.1.5
	 	Indemnification	  	 	13	  
	 6.1.6
	 	Landlord’s Right to Enter	  	 	13	  
	 6.1.7
	 	Personal Property at Tenant’s Risk	  	 	13	  
	 6.1.8
	 	Payment of Landlord’s Cost of Enforcement	  	 	13	  
	 6.1.9
	 	Yield Up	  	 	13	  
	 6.1.10
	 	Rules and Regulations	  	 	14	  
	 6.1.11
	 	Estoppel Certificate	  	 	14	  
	 6.1.12
	 	Landlord’s Expenses Re Consents	  	 	14	  
	 6.2       NEGATIVE COVENANTS
	  	 	14	  
	 6.2.1
	 	Assignment and Subletting	  	 	14	  
	 6.2.2
	 	Nuisance	  	 	15	  
	 6.2.3
	 	Hazardous Wastes and Materials	  	 	15	  
	 6.2.4
	 	Floor Load; Heavy Equipment	  	 	15	  
	 6.2.5
	 	Installation, Alterations or Additions	  	 	16	  
	 6.2.6
	 	Abandonment	  	 	16	  
	 6.2.7
	 	Signs	  	 	16	  
	 6.2.8
	 	Parking and Storage	  	 	16	  
		
	 ARTICLE 7 CASUALTY OR TAKING
	  	 	16	  
		
	 7.1       TERMINATION
	  	 	16	  
	 7.2       RESTORATION
	  	 	16	  
	 7.3       AWARD
	  	 	16	  

							
	 ARTICLE 8 DEFAULTS
	  	 	17	  
			
	 8.1
	 	EVENTS OF DEFAULT	  	 	17	  
	 8.2
	 	REMEDIES	  	 	17	  
	 8.3
	 	REMEDIES CUMULATIVE	  	 	17	  
	 8.4
	 	LANDLORD’S RIGHT TO CURE DEFAULTS	  	 	17	  
	 8.5
	 	EFFECT OF WAIVERS OF DEFAULT	  	 	18	  
	 8.6
	 	NO WAIVER, ETC.	  	 	18	  
	 8.7
	 	NO ACCORD AND SATISFACTION	  	 	18	  
		
	 ARTICLE 9 RIGHTS OF MORTGAGE HOLDERS
	  	 	18	  
			
	 9.1
	 	RIGHTS OF MORTGAGE HOLDERS	  	 	18	  
	 9.2
	 	LEASE SUPERIOR OR SUBORDINATE TO MORTGAGES	  	 	18	  
		
	 ARTICLE 10 MISCELLANEOUS PROVISIONS
	  	 	18	  
			
	 10.1
	 	NOTICES FROM ONE PARTY TO THE OTHER	  	 	18	  
	 10.2
	 	QUIET ENJOYMENT	  	 	19	  
	 10.3
	 	LEASE NOT TO BE RECORDED	  	 	19	  
	 10.4
	 	LIMITATION OF LANDLORD’S LIABILITY	  	 	19	  
	 10.5
	 	ACTS OF GOD	  	 	19	  
	 10.6
	 	LANDLORD’S DEFAULT	  	 	19	  
	 10.7
	 	BROKERAGE	  	 	19	  
	 10.8    
	 	APPLICABLE LAW AND CONSTRUCTION	  	 	19	  

  
 3 

 NORTHWEST PARK 

L E A S E 
 ARTICLE 1

 Reference Data 
  

	1.1	Subject Referred To.  

 Each reference in this Lease to any of the following
subjects shall be construed to incorporate the data stated for that subject in this Section 1.1. 
  

			
	Date of this Lease:	  	August 1, 2005
		
	Building:	  	The single-story Building in Northwest Park in Burlington, Massachusetts (hereinafter referred to as the “Park”) on a parcel of land shown as Lot             
on a plan dated , and recorded in Middlesex Registry of Deeds in Book             , Page             , and known as 34 Third
Avenue (the Building and such parcel of land hereinafter being collectively referred to as the “Property”).
		
	Premises:	  	A portion of the Building, substantially as shown on Exhibit A attached hereto.
		
	Rentable Floor Area of Premises:	  	Approximately 12,106 square feet.
		
	Landlord:	  	Rodger P. Nordblom, Peter C. Nordblom, George Macomber and John D. Macomber as Trustees of N.W. Building 18 Trust under Declaration of Trust dated June 11, 1974 and recorded in Middlesex Registry of Deeds, Book
            , Page             .
		
	Original Notice Address of Landlord:	  	  
 c/o Nordblom Management Company, Inc.

15 Third Avenue
 Burlington, Massachusetts 01803

		
	Tenant:	  	InfraReDx, Inc., a Delaware corporation
		
	Original Notice Address of Tenant:	  	  
 34 Third Avenue

Burlington, MA 01803

		
	Expiration Date:	  	The last day of the third (3rd) lease year (as hereinafter defined)
		
	Commencement Date:	  	The Date of this Lease.
		
	Annual Fixed Rent Rate:	  	$121,056.00
		
	Monthly Fixed Rent Rate:	  	$10,088.00
		
	Rent Commencement Date:	  	The date which is fourteen days from the Commencement Date.
		
	Letter of Credit Amount:	  	$50,000.00
		
	Tenant’s Percentage:	  	The ratio of the Rentable Floor Area of the Premises to the total rentable area of the Building, which shall initially be deemed to be 45.8%.
		
	Initial Estimate of Tenant’s Percentage of Taxes for the Tax Year:	  	$20,004.00
		
	Initial Estimate of Tenant’s Percentage of Operating Costs for the Calendar Year:	  	$25,200.00

  
 4 

			
	Permitted Uses:	  	Offices, research and development and light manufacturing, including laboratory uses if permitted by the Town of Burlington.
		
	Public Liability Insurance Limits: 	  	
		
	Commercial General Liability:	  	
		
		  	$3,000,000 per occurrence
		  	$5,000,000 general aggregate

  

	1.2	Exhibits.  

 The Exhibits listed below in this section are incorporated in this
Lease by reference and are to be construed as a part of this Lease. 
  

			
	EXHIBIT A	  	Plan showing the Premises.
		
	EXHIBIT B	  	Rules and Regulations.
		
	EXHIBIT C	  	Description of Building Exterior Work.
		
	EXHIBIT D	  	Form Tenant Estoppel Certificate.
		
	EXHIBIT E	  	Form Letter of Credit

  
 5 

 ARTICLE 2 

Premises and Term 
  

	2.1	Premises. Landlord hereby leases to Tenant and Tenant hereby leases from Landlord, subject to and with the benefit of the terms, covenants, conditions and provisions of this Lease, the Premises, excluding
the roof, exterior faces of exterior walls, the common stairways, stairwells, elevators and elevator shafts, and pipes, ducts, conduits, wires, and appurtenant fixtures serving exclusively or in common other parts of the Building (and any areas,
such as the space above the ceiling or in the walls, that may contain such pipes, ducts, conduits, wires or appurtenant fixtures), and if Tenant’s space includes less than entire rentable area of any floor, excluding the central core area of
such floor. Tenant shall have, as appurtenant to the Premises, rights to use in common, subject to reasonable rules of general applicability to tenants of the Building from time to time made by Landlord of which Tenant is given notice provided that
Landlord shall not discriminate against Tenant in the enforcement of any such rules: (a) the common lobbies, hallways, stairways, and elevators of the Building, (b) common walkways and driveways necessary for access to the Building,
(c) the common parking areas serving the Building, and (d) if the Premises include less than the entire rentable area of any floor, the common toilets and other common facilities in the central core area of such floor. 

At no additional charge during the term, Tenant shall be permitted to use up to 59 parking spaces in the parking area serving the Building.

 Landlord reserves the right from time to time, following prior notice to Tenant and without unreasonable interference with use of the
Premises: (a) to install, use, maintain, repair, replace and relocate for service to the Premises and other parts of the Building, or either, pipes, ducts, conduits, wires and appurtenant fixtures within the walls or floors (as applicable) or
above the drop ceiling tiles, wherever located in the Premises or Building, (b) to alter or relocate any other common facility, (c) to make any repairs and replacements to the Premises which Landlord may reasonably deem necessary, and
(d) in connection with any excavation made upon adjacent land of Landlord or others, to enter, and to license others to enter, upon the Premises to do such work as the person causing such excavation deems necessary to preserve the wall of the
Building from injury or damage and to support the same. 
  

	2.2	Term. TO HAVE AND TO HOLD for a term (the “original term”) beginning on the Commencement Date and ending on the Expiration Date, unless sooner terminated as hereinafter provided.

 The term “lease year” as used herein shall mean a period of twelve (12) consecutive full calendar months. The
first lease year shall begin on the Commencement Date if the Commencement Date is the first day of a calendar month; if not, then the first lease year shall commence upon the first day of the calendar month next following the Commencement Date. Each
succeeding lease year shall commence upon the anniversary date of the first lease year. 
  

	2.3	Extension Option. Provided that as of the date of the notice specified below, Tenant is not in default and has not previously been in default of its obligations under this Lease beyond any applicable grace
period, Tenant shall have the right to extend the term of this Lease for one additional period of five (5) years, to begin immediately upon the expiration of the original term of this Lease (the “extended term”). All of the terms,
covenants and provisions of this Lease shall apply to such extended term except that the Annual Fixed Rent Rate for such extension period shall be the market rate at the commencement of such extended term, as determined in accordance with the
procedure set forth in the next paragraph below. If Tenant shall elect to exercise the aforesaid option, it shall do so by giving Landlord notice in writing of its intention to do so not later than one (1) year prior to the expiration of the
original term of this Lease. If Tenant gives such notice, the extension of this Lease shall be automatically effected without the execution of any additional documents, subject to the parties’ agreement on market rate as set forth below. The
original term and the extended term are hereinafter collectively called the “term”. 

 If Tenant exercises the
aforesaid option, then not later than eleven (11) months prior to the expiration of the original term of this Lease Landlord shalt give written notice to Tenant of Landlord’s designation of the market rate. Within fifteen (15) days
following Landlord’s notice, Tenant shall either propose its designation of the market rate by giving notice thereof to Landlord or shall accept Landlord’s designation. Failure on the part of Tenant to give such notice of its designation
shall bind Tenant to Landlord’s designation. If Tenant proposes its designation of the market rate, then Landlord and Tenant shall attempt to agree upon a market rate. If the parties have been unable to reach agreement within thirty
(30) days following Tenant’s designation, then the market rate may be submitted to arbitration by either party as follows: market rate shall be determined by impartial arbitrators, one to be chosen by the Landlord, one to be chosen by
Tenant, and a third to be selected, if necessary, as below provided. The unanimous written decision of the two first chosen, without selection and participation of a third arbitrator, or otherwise, the written decision of a majority of three
arbitrators chosen and selected as aforesaid, shall be conclusive and binding upon Landlord and Tenant. Landlord and Tenant shall each notify the other of its chosen arbitrator within ten (10) days following the call for arbitration and, unless
such two arbitrators shall have reached a unanimous decision within thirty (30) days after their designation, they shall so notify the then President of the Boston Bar Association and request him to select an impartial third arbitrator, who
shall be another office building owner, a real estate counselor or a broker dealing with like types of properties, to determine 

  
 6 

 
market rate as herein defined. Such third arbitrator and the first two chosen shall hear the parties and their evidence and render their decision within thirty (30) days following the
conclusion of such hearing and notify Landlord and Tenant thereof. Landlord and Tenant shall share equally the expense of the third arbitrator (if any). If the dispute between the parties as to a market rate has not been resolved before the
commencement of Tenant’s obligation to pay Fixed Rent based upon such market rate, then Tenant shall pay Fixed Rent under the Lease based upon the market rate designated by Landlord until either the agreement of the parties as to the market
rate, or the decision of the arbitrators, as the case may be, at which time Tenant shall pay any underpayment of Fixed Rent to Landlord, or Landlord shall refund any overpayment of Fixed Rent to Tenant. 

In any event, the Annual Fixed Rent Rate for the extended term shall not be less than the Annual Fixed Rent Rate in effect immediately prior to
such extended term. 
  

	2.4	Zoning Contingency. This Lease is conditioned upon Tenant obtaining from the Town of Burlington a special permit that will allow ancillary research laboratory use by Tenant. Tenant agrees to promptly apply
for and take all necessary steps to obtain such special permit from the Town of Burlington. Landlord, without obligating itself to incur any costs or expenses, shall assist and cooperate with Tenant with respect to obtaining such permit so far as
Tenant reasonably requests. Tenant shall use diligence to obtain such permit on or before August 31, 2005 (the “Outside Date”). However, if Tenant, after having diligently prosecuted its application therefor, fails to obtain such
special permit on or before the Outside Date and such failure is not due to the action or inaction of Tenant, then Tenant may elect to terminate the Lease by giving Landlord written notice of termination no later than three (3) business days
after the Outside Date, such termination to be effective as of the date (the `Effective Termination Date”) specified by Tenant that is no more than ten (10) days after the date of Tenant’s election notice. If Tenant timely exercises
its option to terminate this Lease, then (A) on or before the Effective Termination Date, Tenant shall vacate and yield up the Premises in accordance with the provisions of Section 6.1.9 hereof, and (B) notwithstanding anything to the
contrary contained in this Lease, Tenant shall remove any and all leasehold improvements made by Tenant prior to the Effective Termination Date, and (C) on the Effective Termination Date, this Lease shall terminate without the need for any
further documentation and the parties shall have no further accruing liability or obligation to each other. This provisions of the preceding sentence shall expressly survive the termination of this Lease. 

ARTICLE 3 
 Condition
of Premises 
 The Premises are leased to Tenant in broom clean, as-is condition, without any representations and warranties by
Landlord as to the condition of the Premises or their suitability for Tenant’s use and occupancy, and without any obligation on the part of Landlord to construct or perform any improvements for Tenant, except that Landlord shall, at its expense
resurface the remaining unfinished portion of the Premises’ floor with VCT tile. In addition, Landlord shall, at its expense, renovate the Building exterior as described in Exhibit C attached hereto. 

ARTICLE 4 
 Rent

  

	4.1	The Fixed Rent. Tenant covenants and agrees to pay rent to Landlord at the Original Address of Landlord or at such other place or to such other person or entity as Landlord may by notice in writing to Tenant from time
to time direct, at the Annual Fixed Rent Rate, in equal installments at the Monthly Fixed Rent Rate (which is 1/12th of the Annual Fixed Rent Rate), in advance, without notice or demand, and without setoff, abatement, suspension, deferment,
reduction or deduction, except as otherwise expressly provided herein, on the first day of each calendar month included in the term; and for any portion of a calendar month at beginning of the term, at the rate for the first lease year payable in
advance for such portion. It is the intention of the parties hereto that the obligations of Tenant hereunder shall be separate and independent covenants and agreements, that the Annual Fixed Rent, the Additional Rent and all other sums payable by
Tenant to Landlord shall continue to be payable in all events and that the obligations of Tenant hereunder shall continue unaffected, unless the requirement to pay or perform the same shall have been terminated pursuant to an express provision of
this Lease. 

 If Landlord shall give notice to Tenant that all rent and other payments due hereunder are to be made to
Landlord by electronic funds transfers, so called, or by similar means, Tenant shall make all such payments as shall be due after receipt of said notice by means of said electronic funds transfers (or such similar means as designated by Landlord).

  

	4.2	Additional Rent. Tenant covenants and agrees to pay, as Additional Rent, insurance costs, utility charges, personal property taxes and its pro rata share of taxes and operating costs with respect to the
Premises as provided in this Section 4.2 as follows: 

  

	 	4.2.1	 Real Estate Taxes. Tenant shall pay to Landlord, as additional rent, for each tax period partially or wholly included in the term,
Tenant’s Percentage of Taxes (as hereinafter defined). Tenant shall remit to Landlord, on the first day of each calendar month, estimated payments on account of Taxes, such monthly amounts to be sufficient to provide Landlord, by the time real
estate tax payments are due and payable to any governmental authority responsible for collection of same, a sum equal to the Tenant’s Percentage of Taxes, as reasonably estimated by Landlord from time to

  
 7 

	 	 
time on the basis of the most recent tax data available. The initial calculation of the monthly estimated payments shall be based upon the Initial Estimate of Tenant’s Percentage of Taxes
for the Tax Year and upon quarterly payments being due to the governmental authority on August 1, November 1, February 1 and May 1, and shall be made when the Commencement Date has been determined. If the total of such
monthly remittances for any Tax Year is greater than the Tenant’s Percentage of Taxes for such Tax year, Landlord shall promptly pay to Tenant, or credit against the next accruing payments to be made by Tenant pursuant to this subsection 4.2.1,
the difference; if the total of such remittances is less than the Tenant’s Percentage of Taxes for such Tax Year, Tenant shall pay the difference to Landlord at least ten (10) days prior to the date or dates within such Tax Year that any
Taxes become due and payable to the governmental authority (but in any event no earlier than ten (10) days following a written notice to Tenant, which notice shall set forth the manner of computation of Tenant’s Percentage of Taxes).

 If, after Tenant shall have made reimbursement to Landlord pursuant to this subsection 4.2.1, Landlord shall receive a
refund of any portion of Taxes paid by Tenant with respect to any Tax Year during the term hereof as a result of an abatement of such Taxes by legal proceedings, settlement or otherwise (without either party having any obligation to undertake any
such proceedings), Landlord shall promptly pay to Tenant, or credit against the next accruing payments to be made by Tenant pursuant to this subsection 4.2.1, the Tenant’s Percentage of the refund (less the proportional, pro rata expenses,
including attorneys’ fees and appraisers’ fees, incurred in connection with obtaining any such refund), as relates to Taxes paid by Tenant to Landlord with respect to any Tax Year for which such refund is obtained. 

In the event this Lease shall commence, or shall end (by reason of expiration of the term or earlier termination pursuant to the provisions
hereof), on any date other than the first or last day of the Tax Year, or should the Tax Year or period of assessment of real estate taxes be changed or be more or less than one (1) year, as the case may be, then the amount of Taxes which may
be payable by Tenant as provided in this subsection 4.2.1 shall be appropriately apportioned and adjusted. 
 The term “Taxes”
shall mean all taxes, assessments, betterments and other charges and impositions (including, but not limited to, fire protection service fees and similar charges) levied, assessed or imposed at any time during the term by any governmental authority
upon or against the Property, or taxes in lieu thereof, and additional types of taxes to supplement real estate taxes due to legal limits imposed thereon. If, at any time during the term of this Lease, any tax or excise on rents or other taxes,
however described, are levied or assessed against Landlord with respect to the rent reserved hereunder, either wholly or partially in substitution for, or in addition to, real estate taxes assessed or levied on the Property, such tax or excise on
rents shall be included in Taxes; however, Taxes shall not include franchise, estate, inheritance, succession, capital levy, transfer, income or excess profits taxes assessed on Landlord. Taxes shall include any estimated payment made by Landlord on
account of a fiscal tax period for which the actual and final amount of taxes for such period has not been determined by the governmental authority as of the date of any such estimated payment. 

 

	 	4.2.2	Personal Property Taxes. Tenant shall pay all taxes charged, assessed or imposed upon the personal property of Tenant in or upon the Premises. 

 

	 	4.2.3	Operating Costs. Tenant shall pay to Landlord the Tenant’s Percentage of Operating Costs (as hereinafter defined) incurred by Landlord in any calendar year. Tenant shall remit to Landlord, on the
first day of each calendar month, estimated payments on account of Operating Costs, such monthly amounts to be sufficient to provide Landlord, by the end of the calendar year, a sum equal to the Operating Costs, as reasonably estimated by Landlord
from time to time. The initial monthly estimated payments shall be in an amount equal to 1/12th of the Initial Estimate of Tenant’s Percentage of Operating Costs for the Calendar Year. If, at the expiration of the year in respect of which
monthly installments of Operating Costs shall have been made as aforesaid, the total of such monthly remittances is greater than the actual Operating Costs for such year, Landlord shall promptly pay to Tenant, or credit against the next accruing
payments to be made by Tenant pursuant to this subsection 4.2.3, the difference; if the total of such remittances is less than the Operating Costs for such year, Tenant shall pay the difference to Landlord within twenty (20) days from the date
Landlord shall furnish to Tenant an itemized statement of the Operating Costs, prepared, allocated and computed in accordance with generally accepted accounting principles. Any reimbursement for Operating Costs due and payable by Tenant with respect
to periods of less than twelve (12) months shall be equitably prorated. 

 The term “Operating Costs”
shall mean all costs and expenses incurred for the operation, cleaning, maintenance, repair and upkeep of the Property, and the portion of such costs and expenses with regard to the common areas, facilities and amenities of the Park which is
equitably allocable to the Property, including, without limitation, all costs of maintaining and repairing the Property and the Park (including snow removal, landscaping and grounds maintenance, operation and maintenance of parking lots, sidewalks,
walking paths, access roads and driveways, security, operation and repair of heating and air-conditioning equipment, elevators, lighting and any other Building equipment or systems) and of all repairs and replacements (other than repairs or
replacements for which Landlord has received full reimbursement from contractors, other tenants of the Building or from others) necessary to keep the Property and the Park in good working order, repair,

  
 8 

 
appearance and condition; all costs, including material and equipment costs, for cleaning and janitorial services to the Building (including window cleaning of the Building); all costs of any
reasonable insurance carried by Landlord relating to the Property; all costs related to provision of heat (including oil, electric, steam and/or gas), air-conditioning, and water (including sewer charges) and other utilities to the Building
(exclusive of reimbursement to Landlord for any of same received as a result of direct billing to any tenant of the Building); payments under all service contracts relating to the foregoing; all compensation, fringe benefits, payroll taxes and
workmen’s compensation insurance premiums related thereto with respect to any employees of Landlord or its affiliates engaged in security and maintenance of the Property and the Park; reasonable attorneys’ fees and disbursements (exclusive
of any such fees and disbursements incurred in tax abatement proceedings or the preparation of leases) and auditing and other professional fees and expenses; and a management fee. 

There shall not be included in such Operating Costs brokerage fees or other costs associated with Landlord leasing additional property within
the Park (including rental fees) related to the operation of the Building; interest and depreciation charges incurred on the Property; or expenditures made by Tenant with respect to (i) cleaning, maintenance and upkeep of the Premises, and
(ii) the provision of electricity to the Premises. 
 lf, during the term of this Lease, Landlord shall replace any capital items or
make any capital expenditures (collectively called “capital expenditures”) such cost shall be included in Operating Costs for each calendar year in which and after such capital expenditure is made the annual charge-off of such capital
expenditure. (Annual charge-off shall be determined by (i) dividing the original cost of the capital expenditure by the number of years of useful life thereof [The useful life shall be reasonably determined by Landlord in accordance with
generally accepted accounting principles and practices in effect at the time of acquisition of the capital item.); and (ii) adding to such quotient an interest factor computed on the unamortized balance of such capital expenditure based upon an
interest rate reasonably determined by Landlord as being the interest rate then being charged for long-term mortgages by institutional lenders on like properties within the locality in which the Building is located.) Provided, further, that if
Landlord reasonably concludes on the basis of engineering estimates that a particular capital expenditure will effect savings in Operating Costs and that such annual projected savings will exceed the annual charge-off of capital expenditure computed
as aforesaid, then and in such events, the annual charge-off shall be determined by dividing the amount of such capital expenditure by the number of years over which the projected amount of such savings shall fully amortize the cost of such capital
item or the amount of such capital expenditure; and by adding the interest factor, as aforesaid. 
 If during any portion of any year for
which Operating Costs are being computed, the Building was not fully occupied by tenants or if not all of such tenants were paying fixed rent or if Landlord was not supplying all tenants with the services, amenities or benefits being supplied
hereunder, actual Operating Costs incurred shall be reasonably extrapolated by Landlord to the estimated Operating Costs that would have been incurred if the Building were fully occupied by tenants and all such tenants were then paying fixed rent or
if such services were being supplied to all tenants, and such extrapolated amount shall, for the purposes of this Section 4.23, be deemed to be the Operating Costs for such year. 

 

	 	4.2.4	Insurance. Tenant shall, at its expense, as Additional Rent, take out and maintain throughout the term the following insurance protecting Landlord: 

 

	 	4.2.4.1	Commercial general liability insurance naming Landlord, Tenant, and Landlord’s managing agent and any mortgagee of which Tenant has been given notice as insureds or additional insureds and indemnifying the parties
so named against all claims and demands for death or any injury to person or damage to property which may be claimed to have occurred on the Premises (or the Property, insofar as used by customers, employees, servants or invitees of the Tenant), in
amounts which shall, at the beginning of the term, be at least equal to the limits set forth in Section 1.1, and, which, from time to time during the term, shall be for such higher limits, if any, as are customarily carried in the area in which
the Premises are located on property similar to the Premises and used for similar purposes; and workmen’s compensation insurance with statutory limits covering all of Tenant’s employees working on the Premises. 

 

	 	4.2.4.2	Fire insurance with the usual extended coverage endorsements covering all Tenant’s furniture, furnishings, fixtures and equipment. 

 

	 	4.2.4.3	All such policies shall be obtained from responsible companies qualified to do business and in good standing in Massachusetts, which companies and the amount of insurance allocated thereto shall be subject to
Landlord’s approval. Tenant agrees to furnish Landlord with certificates evidencing all such insurance prior to the beginning of the term hereof and evidencing renewal thereof at least thirty (30) days prior to the expiration of any such
policy. Each such policy shall be non-cancelable with respect to the interest of Landlord without at least ten (10) days’ prior written notice thereto. In the event provision for any such insurance is to be by a blanket insurance policy,
the policy shall allocate a specific and sufficient amount of coverage to the Premises. 

  
 9 

	 	4.2.4.4	All insurance which is carried by either party with respect to the Building, Premises or to furniture, furnishings, fixtures, or equipment therein or alterations or improvements thereto, whether or not required, shall
include provisions which either designate the other party as one of the insured or deny to the insurer acquisition by subrogation of rights of recovery against the other party to the extent such rights have been waived by the insured party prior to
occurrence of loss or injury, insofar as, and to the extent that, such provisions may be effective without making it impossible to obtain insurance coverage from responsible companies qualified to do business in the state in which the Premises are
located (even though extra premium may result therefrom). In the event that extra premium is payable by either party as a result of this provision, the other party shall reimburse the party paying such premium the amount of such extra premium. If at
the request of one party, this non-subrogation provision is waived, then the obligation of reimbursement shall cease for such period of time as such waiver shall be effective, but nothing contained in this subsection shall derogate from or otherwise
affect releases elsewhere herein contained of either party for claims. Each party shall be entitled to have certificates of any policies containing such provisions. Each party hereby waives all rights of recovery against the other for loss or injury
against which the waiving party is protected by insurance containing said provisions, reserving, however, any rights with respect to any excess of loss or injury over the amount recovered by such insurance. Tenant shall not acquire as insured under
any insurance carried on the Premises any right to participate in the adjustment of loss or to receive insurance proceeds and agrees upon request promptly to endorse and deliver to Landlord any checks or other instruments in payment of loss in which
Tenant is named as payee. 

  

	 	4.2.5	Utilities. Tenant shall pay directly to the appropriate public authority or utility for the cost of gas and electricity furnished or consumed on the Premises and separately metered, all charges for any
utilities supplied by Landlord pursuant to Subsection 5.1.3 which are separately metered, and all charges for telephone and other utilities or services not supplied by Landlord pursuant to Subsections 5.1.1 and 5.1.3, whether designated as a charge,
tax, assessment, fee or otherwise, all such charges to be paid as the same from time to time become due. Except as otherwise provided in Article 5, it is understood and agreed that Tenant shall make its own arrangements for the installation or
provision of all such utilities and that Landlord shall be under no obligation to furnish any utilities to the Premises and shall not be liable for any interruption or failure in the supply of any such utilities to the Premises.

  

	4.3	Late Payment of Rent. If any installment of rent is paid after the date the same was due, and if on a prior occasion in the twelve (12) month period prior to the date such installment was due an
installment of rent was paid after the same was due, then Tenant shall pay Landlord a late payment fee equal to five (5%) percent of the overdue payment. 

 

	4.4	Letter of Credit. The performance of Tenant’s obligations under this Lease shall be secured by a letter of credit throughout the term hereof in accordance with and subject to the following terms and
conditions: 

  

	 	4.4.1	Amount of Letter of Credit. Concurrently with Tenant’s execution and delivery of this Lease, Tenant shall deliver to Landlord an irrevocable standby letter of credit (the “Original Letter of
Credit”) which shall be (i) in the form of Exhibit E attached to this Lease (the “Form LC”), (ii) issued by a bank reasonably satisfactory to Landlord upon which presentment may be made in Boston, Massachusetts,
(iii) in the amount equal to the Letter of Credit Amount, and (iv) for a term of at least 1 year, subject to the provisions of Section 4.4.2 below. The Original Letter of Credit, any Additional Letters(s) of Credit and Substitute
Letter(s) of Credit are referred to herein as the “Letter of Credit.” 

  

	 	4.4.2	Renewal of Letter of Credit. Each Letter of Credit shall be automatically renewable in accordance with the second to last paragraph of the Form LC; provided however, that Tenant shall be required to
deliver to Landlord a new letter of credit (a “Substitute Letter of Credit”) satisfying the requirements for the Original Letter of Credit under Section 4.4.1 on or before the date 30 days prior to the expiration of the term of the
Letter of Credit then in effect, if the issuer of such Letter of Credit gives notice of its election not to renew such Letter of Credit for any additional period pursuant thereto. Should any Letter of Credit contain a final expiration date, in
addition to a current expiration date, such final expiration date shall be no earlier than 45 days following the Expiration Date of this Lease. 

  

	 	4.4.3	Draws to Cure Defaults. If the Fixed Rent, Additional Rent or any other sum payable to Landlord hereunder shall be overdue and unpaid or should Landlord make payments on behalf of the Tenant, or Tenant
shall fail to perform any of the terms of this Lease in all cases beyond the expiration of all applicable notice and cure periods, then Landlord shall have the right, at any time thereafter to draw down from the Letter of Credit the amount necessary
to cure such default. In the event of any such draw by the Landlord, Tenant shall, within 30 days of written demand therefor, deliver to Landlord an additional Letter of Credit (“Additional Letter of Credit”) satisfying the requirements
for the Original Letter of Credit, except that the amount of such Additional Letter of Credit shall be the amount of such draw. 

  
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	 	4.4.4	Draws to Pay Damages. In addition, if (i) this Lease shall have been terminated as a result of Tenant’s default under this Lease beyond the expiration of the applicable cure period, and/or
(ii) this Lease shall have been rejected in a bankruptcy or other creditor-debtor proceeding, then Landlord shall have the right at any time thereafter to draw down from the Letter of Credit an amount sufficient to pay any and all damages
payable by Tenant on account of such termination or rejection, as the case may be, pursuant to Article 8 hereof. In the event of bankruptcy or other creditor-debtor proceeding against Tenant, all proceeds of the Letter of Credit shall be deemed to
be applied first to the payment of rent and other charges due Landlord for all periods prior to the filing of such proceedings. 

  

	 	4.4.5	Draws for Failure to Deliver Substitute Letter of Credit. If Tenant fails timely to deliver to Landlord a Substitute Letter of Credit, then Landlord shall have the right, at any time thereafter, without
giving any notice to Tenant, to draw down the Letter of Credit and to hold the proceeds thereof (“Security Proceeds”) in a bank account in the name of Landlord, which may be withdrawn and applied by Landlord under the same circumstances
and for the same purposes as if the Security Proceeds were a Letter of Credit. Upon any such application of Security Proceeds by Landlord, Tenant shall, within 30 days of written demand therefor, deliver to Landlord an Additional Letter of Credit in
the amount of Security Proceeds so applied. 

  

	 	4.4.6	Transferability. Landlord shall be entitled to transfer its beneficial interest under the Letter of Credit or any Security Proceeds in connection with (i) Landlord’s sale or transfer of
the Building, or (ii) the addition, deletion or modification of any beneficiaries under the Letter of Credit, and the Letter of Credit shall specifically state on its face that it is transferable by Landlord, its successors and assigns. Tenant
agrees to pay Landlord upon demand, as Additional Rent, all costs and fees charged to effect such transfer. 

  

	 	4.4.7	Return of Letter of Credit at End of Term. Within 45 days after the expiration or earlier termination of the term, to the extent Landlord has not previously drawn upon any Letter of Credit or Security
Proceeds held by Landlord, Landlord shall return the same to Tenant provided that there is not at such time any continuing default of any of Tenant’s obligations under this Lease. 

ARTICLE 5 

Landlord’s Covenants 
  

	5.1	Affirmative Covenants. Landlord covenants with Tenant: 

  

	 	5.1.1	Heat and Air-Conditioning. To furnish to the Premises, separately metered for gas and at the direct expense of Tenant as hereinabove provided, heat and air-conditioning (reserving the right, at any time,
to change energy or heat sources) sufficient to maintain the Premises at comfortable temperatures (subject to all federal, state, and local regulations relating to the provision of heat), during such hours of the day and days of the year that the
Building is normally open. 

  

	 	5.1.2	Electricity. To furnish to the Premises, separately metered and at the direct expense of Tenant as hereinabove provided, reasonable electricity for Tenant’s Permitted Uses. If Tenant shall require
electricity in excess of reasonable quantities for Tenant’s Permitted Uses and if (i) in Landlord’s reasonable judgment, Landlord’s facilities are inadequate for such excess requirements, or (ii) such excess use shall result
in an additional burden on the Building utilities systems and additional cost to Landlord on account thereof, as the case may be, (a) Tenant shall, upon demand, reimburse Landlord for such additional cost, as aforesaid, or (b) Landlord,
upon written request, and at the sole cost and expense of Tenant, will furnish and install such additional wire, conduits, feeders, switchboards and appurtenances as reasonably may be required to supply such additional requirements of Tenant (if
electricity therefor is then available to Landlord), provided that the same shall be permitted by applicable laws and insurance regulations and shall not cause permanent damage or injury to the Building or cause or create a dangerous or hazardous
condition or entail excessive or unreasonable alterations or repairs. 

  

	 	5.1.3	Water. To furnish water for ordinary cleaning, lavatory and toilet facilities. 

  

	 	5.1.4	Elevator; Fire Alarm. To furnish elevator service (if any) from the lobby to the Premises; and to maintain fire alarm systems within the Building. 

 

	 	5.1.5	Repairs. Except as otherwise expressly provided herein, to make such repairs and replacements to the roof, exterior walls, floor slabs and other structural components of the Building, and to the common
areas, facilities and plumbing, electrical, heating, ventilating and air-conditioning systems of the Building as may be necessary to keep them in good repair and condition (exclusive of equipment installed by Tenant and except for those repairs
required to be made by Tenant pursuant to Section 6.1.3 hereof and, subject to the provisions of Section 4.2.4.4 hereof, repairs or replacements occasioned by any act or negligence of Tenant, its servants, agents, customers, contractors,
employees, invitees, or licensees). 

  

	5.2	 Interruption. Landlord shall be under no responsibility or liability for failure or interruption of any of the above-described services,
repairs or replacements caused by breakage, accident, strikes, repairs, inability to obtain supplies, labor or materials, or for any other causes beyond the control of the Landlord, and in no 

  
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event for any indirect or consequential damages to Tenant; and failure or omission on the part of the Landlord to furnish any of same for any of the reasons set forth in this paragraph shall not
be construed as an eviction of Tenant, actual or constructive, nor entitle Tenant to an abatement of rent, nor render the Landlord liable in damages, nor release Tenant from prompt fulfillment of any of its covenants under this Lease. However, in
each instance of interruption or failure, Landlord shall use diligence to eliminate the cause thereof. Notwithstanding anything to contrary contained in this paragraph, if Landlord fails to provide any service, repair or maintenance that it is
required to provide under this Lease so that Tenant cannot reasonably continue to operate its business in the Premises or any portion thereof and such failure continues for five (5) consecutive business days after written notice thereof from
Tenant to Landlord, then, provided that such failure or Landlord’s inability to cure such condition is not due to a cause beyond Landlord’s reasonable control generally affecting other buildings in the vicinity of the Premises (such as a
neighborhood power outage) or a fire or other casualty or taking (which shall be governed by Article 7 below) or the fault or negligence of Tenant or any of its agents, employees or contractors, the Fixed Rent and Additional Rent shall be equitably
abated based upon the impact thereof on Tenant’s ability to conduct business in the Premises until such service(s) is completely restored. 

  

	5.4	Outside Services. In the event Tenant wishes to provide outside services for the Premises over and above those services to be provided by Landlord as set forth herein, Tenant shall first obtain the prior
written approval of Landlord, which shall not be unreasonably withheld, conditioned or delayed, for the installation and/or utilization of such services (“Outside services” shall include, but shall not be limited to, cleaning services,
television, so-called “canned music” services, security services, catering services and the like.) In the event Landlord approves the installation and/or utilization of such services, such installation and utilization shall be at
Tenant’s sole cost, risk and expense. 

  

	5.5	Access. Tenant shall have access to the Premises 24 hours per day, 7 days per week, 365 days per year. 

  

	5.6	Landlord’s Insurance. To take out and maintain throughout the term, (i) All Risk Property insurance with the usual extended coverage endorsements covering the Building, and all improvements
located within the Building, excluding those installed by or on behalf of Tenant, in an amount equal to at least 100% of the replacement cost of the Building, and improvements, as reasonably estimated by Landlord; and (ii) comprehensive general
liability insurance in commercially reasonable amounts as determined by Landlord. 

 ARTICLE 6 

Tenant’s Additional Covenants 
  

	6.1	Affirmative Covenants. Tenant covenants at all times during the term and for such further time (prior or subsequent thereto) as Tenant occupies the Premises or any part thereof: 

 

	 	6.1.1	Perform Obligations. To perform promptly all of the obligations of Tenant set forth in this Lease; and to pay when due the Fixed Rent and Additional Rent and all charges, rates and other sums which by the
terms of this Lease are to be paid by Tenant. 

  

	 	6.1.2	Use. To use the Premises only for the Permitted Uses, and from time to time to procure all licenses and permits necessary therefor, at Tenant’s sole expense. With respect to any licenses or permits
for which Tenant may apply, pursuant to this subsection 6.1.2 or any other provision hereof, Tenant shall furnish Landlord copies of applications therefor on or before their submission to the governmental authority. 

 

	 	6.1.3	Repair and Maintenance. To maintain the Premises in neat order and condition and to perform all routine and ordinary repairs to the Premises and to any plumbing, heating, electrical, ventilating and
air-conditioning systems located within the Premises and installed by Tenant such as are necessary to keep them in good working order, appearance and condition, as the case may require, reasonable use and wear thereof and damage by fire or by
unavoidable casualty only excepted; to keep all glass in windows and doors of the Premises (except glass in the exterior walls of the Building) whole and in good condition with glass of the same quality as that injured or broken; and, without
diminishing the effect of the waiver of subrogation contained in Subsection 4.2.4.4, to make as and when needed as a result of misuse by, or neglect or improper conduct of Tenant or Tenant’s servants, employees, agents, invitees or licensees or
otherwise, all repairs necessary, which repairs and replacements shall be in quality and class equal to the original work. In addition, Tenant shall be responsible for providing cleaning and janitorial services to the Premises, at its expense, and
shall contract for trash removal on a regular basis, at its expense, it being understood that Landlord shall have no obligation to provide cleaning or trash removal. (Landlord, upon default of Tenant hereunder and upon prior notice to Tenant, may
elect, at the expense of Tenant, to perform all such cleaning and maintenance and to make any such repairs or to repair any damage or injury to the Building or the Premises caused by moving property of Tenant in or out of the Building, or by
installation or removal of furniture or other property, or by misuse by, or neglect, or improper conduct of, Tenant or Tenant’s servants, employees, agents, contractors, customers, patrons, invitees, or licensees.) 

  
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	 	6.1.4	Compliance with Law. To make all repairs, alterations, additions or replacements to the Premises required by any law or ordinance or any future order or regulation of any public authority; to keep the
Premises equipped with all safety appliances so required; and to comply with the orders and regulations of all governmental authorities with respect to zoning, building, fire, health and other codes, regulations, ordinances or laws applicable to the
Premises, except that Tenant may defer compliance so long as the validity of any such law, ordinance, order or regulations shall be contested by Tenant in good faith and by appropriate legal proceedings, if Tenant first gives Landlord appropriate
assurance or security against any loss, cost or expense on account thereof. 

  

	 	6.1.5	Indemnification. To save harmless, exonerate and indemnify Landlord, its agents (including, without limitation, Landlord’s managing agent) and employees (such agents and employees being referred to
collectively as the “Landlord Related Parties”) from and against any and all claims, liabilities or penalties asserted by or on behalf of any person, firm, corporation or public authority on account of injury, death, damage or loss to
person or property in or upon the Premises and the Property arising out of the use or occupancy of the Premises by Tenant or by any person claiming by, through or under Tenant (including, without limitation, all patrons, employees and customers of
Tenant), or arising out of any delivery to or service supplied to the Premises, or on account of or based upon anything whatsoever done on the Premises, except if the same was caused by the willful negligence, fault or misconduct of Landlord or the
Landlord Related Parties. In respect of all of the foregoing, Tenant shall indemnify Landlord and the Landlord Related Parties from and against all costs, expenses (including reasonable attorneys’ fees), and liabilities incurred in or in
connection with any such claim, action or proceeding brought thereon; and, in case of any action or proceeding brought against Landlord or the Landlord Related Parties by reason of any such claim, Tenant, upon notice from Landlord and at
Tenant’s expense, shall resist or defend such action or proceeding and employ counsel therefor reasonably satisfactory to Landlord. 

  

	 	6.1.6	Landlord’s Right to Enter. Following reasonable prior notice (except in emergencies), to permit Landlord and its agents to enter into and examine the Premises at reasonable times and to show the
Premises, provided, however, that with respect to prospective tenants Landlord shall be permitted to show the Premises only during the last nine (9) months of the term, and to make repairs to the Premises, and, during the last six
(6) months prior to the expiration of this Lease, to keep affixed in suitable places notices of availability of the Premises. 

  

	 	6.1.7	Personal Property at Tenant’s Risk. All of the furnishings, fixtures, equipment, effects and property of every kind, nature and description of Tenant and of all persons claiming by, through or under
Tenant which, during the continuance of this Lease or any occupancy of the Premises by Tenant or anyone claiming under Tenant, may be on the Premises, shall be at the sole risk and hazard of Tenant and if the whole or any part thereof shall be
destroyed or damaged by fire, water or otherwise, or by the leakage or bursting of water pipes, steam pipes, or other pipes, by theft or from any other cause, no part of said loss or damage is to be charged to or to be borne by Landlord, except that
Landlord shall in no event be indemnified or held harmless or exonerated from any liability to Tenant or to any other person, for any injury, loss, damage or liability to the extent prohibited by law. 

 

	 	6.1.8	Payment of Landlord’s Cost of Enforcement. To pay on demand Landlord’s expenses, including reasonable attorneys’ fees, incurred in enforcing any obligation of Tenant under this Lease or in
curing any default by Tenant under this Lease as provided in Section 8.4. 

  

	 	6.1.9	Yield Up. At the expiration of the term or earlier termination of this Lease: to surrender all keys to the Premises; to remove all of its trade fixtures and personal property in the Premises; to deliver to
Landlord stamped architectural plans showing the Premises at yield up (which may be the initial plans if Tenant has made no installations after the Commencement Date); to remove such installations made by it as Landlord may request (including
computer and telecommunications wiring and cabling, it being understood that if Tenant leaves such wiring and cabling in a useable condition, Landlord, although having the right to request removal thereof, is less likely to so request) and all
Tenant’s signs wherever located; to repair all damage caused by such removal and, with regard to any portion of the Premises which was in an open-office configuration as of the Commencement Date, to restore the Premises to an open-office
configuration if requested by Landlord and to yield up the Premises (including all installations and improvements made by Tenant except for trade fixtures and such of said installations or improvements as Landlord shall request Tenant to remove),
broom-clean and in the same good order and repair in which Tenant is obliged to keep and maintain the Premises by the provisions of this Lease. Tenant, at the time of making any installation, may request in writing Landlord’s written permission
to leave such installation in the Premises at the expiration or earlier termination of this Lease. Landlord shall, after receipt of Tenant’s request, notify Tenant in writing as to whether such installation may or may not remain in the Premises
at the expiration or earlier termination of this Lease. If Landlord so notifies Tenant that such installation may remain in the Premises at the expiration or earlier termination of this Lease, Landlord shall thereafter not be permitted to request or
require that such installation be removed at the expiration or earlier termination of the Lease. Any property not so removed shall be deemed abandoned and, if Landlord so elects, deemed to be Landlord’s property, and may be retained or removed
and disposed of by Landlord in such manner as Landlord shall determine and Tenant shall pay Landlord the entire cost and expense incurred by it in effecting such removal and disposition and in making any incidental repairs and replacements to the
Premises and for use and occupancy during the period after the expiration of the term and prior to its performance of its obligations under this subsection 6.1.9. Tenant shall further indemnify Landlord against all loss, cost and damage
resulting from Tenant’s failure and delay in surrendering the Premises as above provided. 

  
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	 	    	If the Tenant remains in the Premises beyond the expiration or earlier termination of this Lease, such holding over shall be without right and shall not be deemed to create any tenancy, but the Tenant shall be a tenant
at sufferance only at a daily rate of rent equal to two (2) times the rent and other charges in effect under this Lease as of the day prior to the date of expiration of this Lease. 

 

	 	6.1.10	Rules and Regulations. To comply with the Rules and Regulations set forth in Exhibit E, and with all reasonable Rules and Regulations of general applicability to all tenants of the Building hereafter made
by Landlord, of which Tenant has been given notice; Landlord shall not be liable to Tenant for the failure of other tenants of the Building to conform to such Rules and Regulations. In the event of a conflict between the Rules and Regulations and
the provisions of this Lease, the provisions of this Lease shall govern. 

  

	 	6.1.11	Estoppel Certificate. Upon not less than ten (10) days’ prior written request by Landlord, to execute, acknowledge and deliver to Landlord a statement in writing, which may be in the form
attached hereto as Exhibit F or in another form reasonably similar thereto, or such other form as Landlord may provide from time to time, certifying all or any of the following: (i) that this Lease is unmodified (or if modified, to what extent)
and in full force and effect, (ii) whether the term has commenced and Fixed Rent and Additional Rent have become payable hereunder and, if so, the dates to which they have been paid, (iii) whether or not Landlord is in default in
performance of any of the terms of this Lease, (iv) whether Tenant has accepted possession of the Premises, (v) whether Tenant has made any claim against Landlord under this Lease and, if so, the nature thereof and the dollar amount, if
any, of such claim, (vi) whether there exist any offsets or defenses against enforcement of any of the terms of this Lease upon the part of Tenant to be performed, and (vii) such further information with respect to the Lease or the
Premises as Landlord may reasonably request. Any such statement delivered pursuant to this subsection 6.1.11 may be relied upon by any prospective purchaser or mortgagee of the Premises, or any prospective assignee of such mortgage. Tenant shall
also deliver to Landlord such financial information as may be reasonably required by Landlord to be provided to any mortgagee or prospective purchaser of the Premises. 

 

	 	6.1.12	Landlord’s Expenses Re Consents. To reimburse Landlord promptly on demand for all reasonable legal expenses incurred by Landlord in connection with all requests by Tenant for consent or approval
hereunder. 

  

	6.2	Negative Covenants. Tenant covenants at all times during the term and such further time (prior or subsequent thereto) as Tenant occupies the Premises or any part thereof: 

 

	 	6.2.1	Assignment and Subletting. Not to assign, transfer, mortgage or pledge this Lease or to sublease (which term shall be deemed to include the granting of concessions and licenses and the like) all or any
part of the Premises or suffer or permit this Lease or the leasehold estate hereby created or any other rights arising under this Lease to be assigned, transferred or encumbered, in whole or in part, whether voluntarily, involuntarily or by
operation of law, or permit the occupancy of the Premises by anyone other than Tenant without the prior written consent of Landlord. In the event Tenant desires to assign this Lease or sublet any portion or all of the Premises, Tenant shall notify
Landlord in writing of Tenant’s intent to so assign this Lease or sublet the Premises and the proposed effective date of such subletting or assignment, and shall request in such notification that Landlord consent thereto. Within fifteen
(15) days of Tenant’s request to assign or sublet, Landlord may terminate this Lease in the case of a proposed assignment, or suspend this Lease pro Canto for the period and with respect to the space involved in the case of a proposed
subletting, by giving written notice of termination or suspension to Tenant, with such termination or suspension to be effective as of the effective date of such assignment or subletting. If Landlord does not so terminate or suspend, Landlord’s
consent shall not be unreasonably withheld, conditioned or delayed to an assignment or to a subletting, provided that the following conditions are met: 

  

	 	(i)	the assignee or subtenant shall use the Premises only for the Permitted Uses; 

  

	 	(ii)	with respect to a subletting, that after such subletting the initial Tenant named herein occupies at least fifty (50%) percent of the Rentable Floor Area of the Premises; 

 

	 	(iii)	the proposed assignee or subtenant has a net worth and creditworthiness reasonably acceptable to Landlord; 

  

	 	(iv)	the amount of the aggregate rent to be paid by the proposed subtenant is not less than the then current sublease market rate for the Premises; and 

 

	 	(v)	the proposed assignee or subtenant is not then a tenant in the Building or the Park, or an entity with which Landlord is dealing or has dealt within the preceding six months regarding the possibility of leasing space in
the Building or the Park, unless Landlord is unable to satisfy such proposed assignee or subtenant’s needs based on the current availability in the Park. 

  
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	 	    	Tenant shall furnish Landlord with any information reasonably requested by Landlord to enable Landlord to determine whether the proposed assignment or subletting complies with the foregoing requirements, including
without limitation, financial statements relating to the proposed assignee or subtenant. With respect to any assignment or subletting during the original term of this Lease, such assignment shall not include the right granted to Tenant under
Section 2.3 hereinabove to extend the term, and such sublease shall be for a term expiring no later than the Expiration Date. 

  

	 	    	Tenant shall, as Additional Rent, reimburse Landlord promptly for Landlord’s reasonable legal expenses incurred in connection with any request by Tenant for such consent. If Landlord consents thereto, no such
subletting or assignment shall in any way impair the continuing primary liability of Tenant hereunder, and no consent to any subletting or assignment in a particular instance shall be deemed to be a waiver of the obligation to obtain the
Landlord’s written approval in the case of any other subletting or assignment. 

  

	 	    	If for any assignment or sublease consented to by Landlord hereunder Tenant receives rent or other consideration, either initially or over the term of the assignment or sublease, in excess of the rent called for
hereunder, or in case of sublease of part, in excess of such rent fairly allocable to the part, after appropriate adjustments to assure that all other payments called for hereunder are appropriately taken into account and after deduction for
reasonable marketing expenses of Tenant in connection with the assignment or sublease (including brokerage fees, legal fees, and all commercially reasonable rental concessions, which shall be amortized over the term of the sublease), to pay to
Landlord as additional rent fifty (50%) percent of the excess of each such payment of rent or other consideration received by Tenant promptly after its receipt. 

 

	 	    	Whenever Tenant lists with a broker or brokers or otherwise advertises, holds out or markets the Premises or any part thereof for sublease or assignment, Tenant shall give Nordblom Company, as brokers, a non-exclusive
listing with respect to such sublease or assignment, provided, however, Tenant shall not be required to pay brokerage fees to Nordblom Company in the event Tenant has engaged its own representative to market the Premises, unless Nordblom Company was
the procuring broker for such replacement tenant. 

  

	 	    	If at any time during the term of this Lease, there is a name change, reformation or reorganization of the Tenant entity, Tenant shall so notify Landlord and deliver evidence reasonably satisfactory to Landlord
documenting such name change, reformation or reorganization. If, at any time during the term of this Lease, there is a transfer of a controlling interest in the stock, membership or general partnership interests of Tenant, Tenant shall so notify
Landlord and (whether or not Tenant so notifies Landlord) Landlord may terminate this Lease by notice to Tenant given within ninety (90) days thereafter. 

  

	 	    	Any other provision of this Section 6.2.1 notwithstanding, Tenant shall have the right, without Landlord’s prior written consent and without any right of Landlord to terminate or suspend this Lease, to assign
this Lease of sublease all or a portion of the Premises to any of the following entities: (A) an entity into or with which Tenant is merged or consolidated or to which all or substantially all of Tenant’s stock or assets are transferred,
provided that in any of such events (i) the successor to Tenant has a net worth computed in accordance with generally accepted accounting principles at least equal to the net worth of Tenant immediately prior to such merger, consolidation or
transfer, (ii) proof reasonably satisfactory to Landlord of such net worth shall have been delivered to Landlord at least ten (10) days prior to the effective date of any such transaction, and (iii) the assignee agrees directly with
Landlord, by written instrument in form satisfactory to Landlord, to assume and perform all the obligations of Tenant under this Lease; or (B) an entity which is either a parent of Tenant, controlled by Tenant or under common control with
Tenant; provided, that, in any event Tenant remains primarily liable under this Lease (“control” for the purposes hereof meaning ownership of 50% or more of all financial interest and 50% percent or more of the voting interest).

  

	 	6.2.2	Nuisance. Not to injure, deface or otherwise harm the Premises; nor commit any nuisance; nor permit in the Premises any vending machine (except such as is used for the sale of merchandise to employees of
Tenant) or inflammable fluids or chemicals (except such as are customarily used in connection with standard office equipment); nor permit any cooking to such extent as requires special exhaust venting; nor permit the emission of any objectionable
noise or odor; nor make, allow or suffer any waste; nor make any use of the Premises which is improper, offensive or contrary to any law or ordinance or which will invalidate any of Landlord’s insurance; nor conduct any auction, fire,
“going out of business” or bankruptcy sales. 

  

	 	6.2.3	Hazardous Wastes and Materials. Not to dispose of any hazardous wastes, hazardous materials or oil on the Premises or the Property, or into any of the plumbing, sewage, or drainage systems thereon, and to
indemnify and save Landlord harmless from all claims, liability, loss or damage arising on account of the use or disposal of hazardous wastes, hazardous materials or oil, including, without limitation, liability under any federal, state, or local
laws, requirements and regulations, or damage to any of the aforesaid systems. Tenant shall comply with all governmental reporting requirements with respect to hazardous wastes, hazardous materials and oil, and shall deliver to Landlord copies of
all reports filed with governmental authorities. 

  

	 	6.2.4	 Floor Load; Heavy Equipment. Not to place a load upon any floor of the Premises exceeding the floor load per square foot area which such
floor was designed to carry and which is allowed by law. Landlord reserves the right to prescribe the weight and position of all heavy business machines and equipment, including safes, which shall be placed so as to distribute the weight. 

  
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Business machines and mechanical equipment which cause vibration or noise shall be placed and maintained by Tenant at Tenant’s expense in settings sufficient to absorb and prevent vibration,
noise and annoyance. Tenant shall not move any safe, heavy machinery, heavy equipment, freight or fixtures into or out of the Premises except in such manner and at such time as Landlord shall in each instance authorize. 

 

	 	6.2.5	Installation, Alterations or Additions. With the exception of strictly cosmetic or decorative changes, not to make any installations, alterations or additions in, to or on the Premises nor to permit the
making of any holes in the walls, partitions, ceilings or floors nor the installation or modification of any locks or security devices without on each occasion obtaining the prior written consent of Landlord, which consent shall not be unreasonably
withheld, conditioned or delayed, and then only pursuant to plans and specifications approved by Landlord in advance in each instance; Tenant shall pay promptly when due the entire cost of any work to the Premises undertaken by Tenant so that the
Premises shall at all times be free of liens for labor and materials, and at Landlord’s request Tenant shall furnish to Landlord a bond or other security acceptable to Landlord assuring that any work commenced by Tenant will be completed in
accordance with the plans and specifications theretofore approved by Landlord and assuring that the Premises will remain free of any mechanics’ lien or other encumbrance arising out of such work. In any event, Tenant shall forthwith bond
against or discharge any mechanics’ liens or other encumbrances that may arise out of such work. Tenant shall procure all necessary licenses and permits at Tenant’s sole expense before undertaking such work. All such work shall be done in
a good and workmanlike manner employing materials of good quality and so as to conform with all applicable zoning, building, fire, health and other codes, regulations, ordinances and laws. Tenant shall save Landlord harmless and indemnified from all
injury, loss, claims or damage to any person or property occasioned by or growing out of such work. 

  

	 	    	Not to grant a security interest in, or to lease, any personal property being installed in the Premises (including, without limitation, demountable partitions) without first obtaining an agreement, for the benefit of
Landlord, from the secured party or lessor that such property will be removed within ten (10) business days after notice from Landlord of the expiration or earlier termination of this Lease and that a failure to so remove will subject such
property to the provisions of subsection 6.1.9 of the Lease. 

  

	 	6.2.6	Abandonment. Not to abandon the Premises during the term. 

  

	 	6.2.7	Signs. Not without Landlord’s prior written approval to paint or place any signs or place any curtains, blinds, shades, awnings, aerials, or the like, visible from outside the Premises. Tenant shall
be permitted to install its identification sign on the Building exterior in a location approved by Landlord. Such sign shall conform to the sign policy for the Park and shall comply with all applicable local regulations and codes. Tenant shall be
solely responsible, at its expense, for installing and maintaining such sign, and for removing it at the end of the term. 

  

	 	6.2.8	Parking and Storage. Not to permit any storage of materials outside of the Premises; nor to permit the use of the parking areas for either temporary or permanent storage of trucks; nor permit the use of
the Premises for any use for which heavy trucking would be customary. 

 ARTICLE 7 

Casualty or Taking 
  

	7.1	Termination. In the event that the Premises or the Building, or any material part thereof, shall be taken by any public authority or for any public use, or shall be destroyed or damaged by fire or
casualty, or by the action of any public authority, then this Lease may be terminated at the election of Landlord. Such election, which may be made notwithstanding the fact that Landlord’s entire interest may have been divested, shall be made
by the giving of notice by Landlord to Tenant within sixty (60) days after the date of the taking or casualty. 

  

	7.2	Restoration. If Landlord does not elect to so terminate, this Lease shall continue in force and a just proportion of the rent reserved, according to the nature and extent of the damages sustained by the
Premises, shall be suspended or abated until the Premises, or what may remain thereof, shall be put by Landlord in proper condition for use, which Landlord covenants to do with reasonable diligence to the extent permitted by the net proceeds of
insurance recovered or damages awarded for such taking, destruction or damage and subject to zoning and building laws or ordinances then in existence. “Net proceeds of insurance recovered or damages awarded” refers to the gross amount of
such insurance or damages less the reasonable expenses of Landlord incurred in connection with the collection of the same, including without limitation, fees and expenses for legal and appraisal services. 

 

	7.3	Award. Irrespective of the form in which recovery may be had by law, all rights to damages or compensation shall belong to Landlord in all cases. Tenant hereby grants to Landlord all of Tenant’s
rights to such damages and covenants to deliver such further assignments thereof as Landlord may from time to time request. 

  
 16 

 ARTICLE 8 

Defaults 
  

	8.1	Events of Default. (a) If Tenant shall default in the performance of any of its obligations to pay the Fixed Rent, Additional Rent or any other sum due Landlord hereunder and if such default shall
continue for ten (10) days after written notice from Landlord designating such default or if within thirty (30) days after written notice from Landlord to Tenant specifying any other default or defaults Tenant has not commenced diligently
to correct the default or defaults so specified or has not thereafter diligently pursued such correction to completion, or (b) if any assignment shall be made by Tenant or any guarantor of Tenant for the benefit of creditors, or (c) if
Tenant’s leasehold interest shall be taken on execution, or (d) if a lien or other involuntary encumbrance is filed against Tenant’s leasehold interest or Tenant’s other property, including said leasehold interest, and is not
discharged within ten (10) days thereafter, or (e) if a petition is filed by Tenant or any guarantor of Tenant for liquidation, or for reorganization or an arrangement under any provision of any bankruptcy law or code as then in force and
effect, or (f) if an involuntary petition under any of the provisions of any bankruptcy law or code is filed against Tenant or any guarantor of Tenant and such involuntary petition is not dismissed within thirty (30) days thereafter, then,
and in any of such cases, Landlord and the agents and servants of Landlord lawfully may, in addition to and not in derogation of any remedies for any preceding breach of covenant, immediately or at any time thereafter without demand or notice and
with or without process of law (forcibly, if necessary) enter into and upon the Premises or any part thereof in the name of the whole or mail a notice of termination addressed to Tenant, and repossess the same as of landlord’s former estate and
expel Tenant and those claiming through or under Tenant and remove its and their effects (forcibly, if necessary) without being deemed guilty of any manner of trespass and without prejudice to any remedies which might otherwise be used for arrears
of rent or prior breach of covenants, and upon such entry or mailing as aforesaid this Lease shall terminate, Tenant hereby waiving all statutory rights to the Premises (including without limitation rights of redemption, if any, to the extent such
rights may be lawfully waived) and Landlord, without notice to Tenant, may store Tenant’s effects, and those of any person claiming through or under Tenant, at the expense and risk of Tenant, and, if Landlord so elects, may sell such effects at
public auction or private sale and apply the net proceeds to the payment of all sums due to Landlord from Tenant, if any, and pay over the balance, if any, to Tenant. 

 

	8.2	Remedies. In the event that this Lease is terminated under any of the provisions contained in Section 8.1 or shall be otherwise terminated for breach of any obligation of Tenant, Tenant covenants to
pay forthwith to Landlord, as compensation, the excess of the total rent reserved for the residue of the term over the rental value of the Premises for said residue of the term. In calculating the rent reserved there shall be included, in addition
to the Fixed Rent and Additional Rent, the value of all other considerations agreed to be paid or performed by Tenant for said residue. Tenant further covenants as additional and cumulative obligations after any such termination, to pay punctually
to Landlord all the sums and to perform all the obligations which Tenant covenants in this Lease to pay and to perform in the same manner and to the same extent and at the same time as if this Lease had not been terminated. In calculating the
amounts to be paid by Tenant pursuant to the next preceding sentence Tenant shall be credited with any amount paid to Landlord as compensation as in this Section 8.2 provided and also with the net proceeds of any rent obtained by Landlord by
reletting the Premises, after deducting all Landlord’s expense in connection with such reletting, including, without limitation, all repossession costs, brokerage commissions, fees for legal services and expenses of preparing the Premises for
such reletting, it being agreed by Tenant that Landlord may (i) relet the Premises or any part or parts thereof, for a term or terms which may at Landlord’s option be equal to or less than or exceed the period which would otherwise have
constituted the balance of the term and may grant such concessions and free rent as Landlord in its sole judgment considers advisable or necessary to relet the same and (ii) make such alterations, repairs and decorations in the Premises as
Landlord in its sole judgment considers advisable or necessary to relet the same, and no action of Landlord in accordance with the foregoing or failure to relet or to collect rent under reletting shall operate or be construed to release or reduce
Tenant’s liability as aforesaid. 

  

	    	In lieu of any other damages or indemnity and in lieu of full recovery by Landlord of all sums payable under all the foregoing provisions of this Section 8.2, Landlord may by written notice to Tenant, at any time
after this Lease is terminated under any of the provisions contained in Section 8.1 or is otherwise terminated for breach of any obligation of Tenant and before such full recovery, elect to recover, and Tenant shall thereupon pay, as liquidated
damages, an amount equal to the aggregate of the Fixed Rent and Additional Rent accrued in the twelve (12) months ended next prior to such termination plus the amount of rent of any kind accrued and unpaid at the time of termination and less
the amount of any recovery by Landlord under the foregoing provisions of this Section 8.2 up to the time of payment of such liquidated damages. Nothing contained in this Lease shall, however, limit or prejudice the right of Landlord to prove
for and obtain in proceedings for bankruptcy or insolvency by reason of the termination of this Lease, an amount equal to the maximum allowed by any statute or rule of law in effect at the time when, and governing the proceedings in which, the
damages are to be proved, whether or not the amount be greater than, equal to, or less than the amount of the loss or damages referred to above. 

  

	8.3	Remedies Cumulative. Any and all rights and remedies which Landlord may have under this Lease, and at law and equity, shall be cumulative and shall not be deemed inconsistent with each other, and any two
or more of all such rights and remedies may be exercised at the same time insofar as permitted by law. 

  

	8.4	Landlord’s Right to Cure Defaults. Landlord may, but shall not be obligated to, cure, at any time, without notice, any default by Tenant under this Lease; and whenever Landlord so elects, all costs
and expenses incurred by Landlord, including reasonable attorneys’ fees, in curing a default shall be paid, as Additional Rent, by Tenant to Landlord on demand, together with lawful interest thereon from the date of payment by Landlord to the
date of payment by Tenant. 

  
 17 

	8.5	Effect of Waivers of Default. Any consent or permission by Landlord to any act or omission which otherwise would be a breach of any covenant or condition herein, shall not in any way be held or construed
(unless expressly so declared) to operate so as to impair the continuing obligation of any covenant or condition herein, or otherwise, except as to the specific instance, operate to permit similar acts or omissions. 

 

	8.6	No Waiver, etc. The failure of Landlord to seek redress for violation of, or to insist upon the strict performance of, any covenant or condition of this Lease shall not be deemed a waiver of such violation
nor prevent a subsequent act, which would have originally constituted a violation, from having all the force and effect of an original violation. The receipt by Landlord of rent with knowledge of the breach of any covenant of this Lease shall not be
deemed to have been a waiver of such breach by Landlord. No consent or waiver, express or implied, by Landlord to or of any breach of any agreement or duty shall be construed as a waiver or consent to or of any other breach of the same or any other
agreement or duty. 

  

	8.7	No Accord and Satisfaction. No acceptance by Landlord of a lesser sum than the Fixed Rent, Additional Rent or any other charge then due shall be deemed to be other than on account of the earliest
installment of such rent or charge due, nor shall any endorsement or statement on any check or any letter accompanying any check or payment as rent or other charge be deemed an accord and satisfaction, and Landlord may accept such check or payment
without prejudice to Landlord’s right to recover the balance of such installment or pursue any other remedy in this Lease provided. 

ARTICLE 9 
 Rights of
Mortgage Holders 
  

	9.1	Rights of Mortgage Holders. The word “mortgage” as used herein includes mortgages, deeds of trust or other similar instruments evidencing other voluntary liens or encumbrances, and modifications,
consolidations, extensions, renewals, replacements and substitutes thereof. The word “holder” shall mean a mortgagee, and any subsequent holder or holders of a mortgage. Until the holder of a mortgage shall enter and take possession of the
Property for the purpose of foreclosure, such holder shall have only such rights of Landlord as are necessary to preserve the integrity of this Lease as security. Upon entry and taking possession of the Property for the purpose of foreclosure, such
holder shall have all the rights of Landlord. No such holder of a mortgage shall be liable either as mortgagee or as assignee, to perform, or be liable in damages for failure to perform, any of the obligations of Landlord unless and until such
holder shall enter and take possession of the Property for the purpose of foreclosure. Upon entry for the purpose of foreclosure, such holder shall be liable to perform all of the obligations of Landlord, subject to and with the benefit of the
provisions of Section 10.4, provided that a discontinuance of any foreclosure proceeding shall be deemed a conveyance under said provisions to the owner of the equity of the Property. 

 

	    	The covenants and agreements contained in this Lease with respect to the rights, powers and benefits of a holder of a mortgage (particularly, without limitation thereby, the covenants and agreements contained in this
Section 9.1) constitute a continuing offer to any person, corporation or other entity, which by accepting a mortgage subject to this Lease, assumes the obligations herein set forth with respect to such holder; such holder is hereby constituted
a party of this Lease as an obligee hereunder to the same extent as though its name were written hereon as such; and such holder shall be entitled to enforce such provisions in its own name. Tenant agrees on request of Landlord to execute and
deliver from time to time any agreement which may be necessary to implement the provisions of this Section 9.1. 

  

	9.2	Lease Superior or Subordinate to Mortgages. It is agreed that the rights and interest of Tenant under this Lease shall be (i) subject or subordinate to any present or future mortgage or mortgages and
to any and all advances to be made thereunder, and to the interest of the holder thereof in the Premises or any property of which the Premises are a part if Landlord shall elect by notice to Tenant to subject or subordinate the rights and interest
of Tenant under this Lease to such mortgage or (ii) prior to any present or future mortgage or mortgages, if Landlord shall elect, by notice to Tenant, to give the rights and interest of Tenant under this Lease priority to such mortgage; in the
event of either of such elections and upon notification by Landlord to that effect, the rights and interest of Tenant under this Lease should be deemed to be subordinate to, or have priority over, as the case may be, said mortgage or mortgages,
irrespective of the time of execution or time of recording of any such mortgage or mortgages (provided that, in the case of subordination of this Lease to any future mortgages, the holder thereof agrees not to disturb the possession of Tenant so
long as Tenant is not in default hereunder). Tenant agrees it will, upon not less than ten (10) days’ prior written request by Landlord, execute, acknowledge and deliver any and all instruments deemed by Landlord necessary or desirable to
give effect to or notice of such subordination or priority. Any Mortgage to which this Lease shall be subordinated may contain such terms, provisions and conditions as the holder deems usual or customary. Landlord shall use reasonable efforts to
obtain a so-called non-disturbance agreement from its existing lender whereby such lender agrees that Tenant shall not be disturbed in its possession so long as Tenant is not in default beyond the expiration of applicable notice and cure periods
hereunder. 

 ARTICLE 10 

Miscellaneous Provisions 
  

	10.1	Notices from One Party to the Other. All notices required or permitted hereunder shall be in writing and addressed, if to the Tenant, at the Original Notice Address of Tenant or such other address as
Tenant shall have last designated by notice in writing to Landlord and, if to Landlord, at the Original Notice Address of Landlord or such other address as Landlord shall have last designated by notice in writing to Tenant. Any notice shall be
deemed duly given when mailed to such address postage prepaid, by registered or certified mail, return receipt requested, or when delivered to such address by hand. 

  
 18 

	10.2	Quiet Enjoyment. Landlord agrees that upon Tenant’s paying the rent and performing and observing the agreements, conditions and other provisions on its part to be performed and observed, Tenant shall
and may peaceably and quietly have, hold and enjoy the Premises during the term hereof without any manner of hindrance or molestation from Landlord or anyone claiming under Landlord, subject, however, to the terms of this Lease.

  

	10.3	Lease not to be Recorded. Tenant agrees that it will not record this Lease. Both parties shall, upon the request of either, execute and deliver a notice or short form of this Lease in such form, if any, as
may be permitted by applicable statute. Tenant hereby irrevocably appoints Landlord as Tenant’s attorney-in-fact (which appointment shall survive termination of the term of this Lease) with full power of substitution to execute, acknowledge and
deliver a notice of termination of lease in Tenant’s name if Tenant fails, within 10 days after request therefor, to either execute, acknowledge or deliver such notice of termination or give Landlord written notice setting forth the reasons why
Tenant is refusing to deliver such notice of termination. 

  

	10.4	Limitation of Landlord’s Liability. The term “Landlord” as used in this Lease, so far as covenants or obligations to be performed by Landlord are concerned, shall be limited to mean and
include only the owner or owners at the time in question of the Property, and in the event of any transfer or transfers of title to said property, the Landlord (and in case of any subsequent transfers or conveyances, the then grantor) shall be
concurrently freed and relieved from and after the date of such transfer or conveyance, without any further instrument or agreement of all liability as respects the performance of any covenants or obligations on the part of the Landlord contained in
this Lease thereafter to be performed, it being intended hereby that the covenants and obligations contained in this Lease on the part of Landlord, shall, subject as aforesaid, be binding on the Landlord, its successors and assigns, only during and
in respect of their respective successive periods of ownership of said leasehold interest or fee, as the case may be. Tenant, its successors and assigns, shall not assert nor seek to enforce any claim for breach of this Lease against any of
Landlord’s assets other than Landlord’s interest in the Property and in the rents, issues and profits thereof, and Tenant agrees to look solely to such interest for the satisfaction of any liability or claim against Landlord under this
Lease, it being specifically agreed that in no event whatsoever shall Landlord (which term shall include, without limitation, any general or limited partner, trustees, beneficiaries, officers, directors, or stockholders of Landlord) ever be
personally liable for any such liability. 

  

	10.5	Acts of God. In any case where either party hereto is required to do any act, delays caused by or resulting from Acts of God, war, civil commotion, fire, flood or other casualty, labor difficulties,
shortages of labor, materials or equipment, government regulations, unusually severe weather, or other causes beyond such party’s reasonable control shall not be counted in determining the time during which work shall be completed, whether such
time be designated by a fixed date, a fixed time or a “reasonable time,” and such time shall be deemed to be extended by the period of such delay. 

 

	10.6	Landlord’s Default. Landlord shall not be deemed to be in default in the performance of any of its obligations hereunder unless it shall fail to perform such obligations and such failure shall
continue for a period of thirty (30) days or such additional time as is reasonably required to correct any such default after written notice has been given by Tenant to Landlord specifying the nature of Landlord’s alleged default. Landlord
shall not be liable in any event for incidental or consequential damages to Tenant by reason of Landlord’s default, whether or not notice is given. Tenant shall have no right to terminate this Lease for any default by Landlord hereunder and no
right, for any such default, to offset or counterclaim against any rent due hereunder. 

  

	10.7	Brokerage. Tenant warrants and represents that it has dealt with no broker in connection with the consummation of this Lease, other than Nordblom Brokerage Company and Staubach Company (collectively, the
“Brokers”), and in the event of any brokerage claims, other than by the Brokers, against Landlord predicated upon prior dealings with Tenant, Tenant agrees to defend the same and indemnify and hold Landlord harmless against any such
claim. 

  

	10.8	Applicable Law and Construction. This Lease shall be governed by and construed in accordance with the laws of the Commonwealth of Massachusetts and, if any provisions of this Lease shall to any extent be
invalid, the remainder of this Lease shall not be affected thereby. There are no oral or written agreements between Landlord and Tenant affecting this Lease. This Lease may be amended, and the provisions hereof may be waived or modified, only by
instruments in writing executed by Landlord and Tenant. The titles of the several Articles and Sections contained herein are for convenience only and shall not be considered in construing this Lease. Unless repugnant to the context, the words
“Landlord” and “Tenant” appearing in this Lease shall be construed to mean those named above and their respective heirs, executors, administrators, successors and assigns, and those claiming through or under them respectively. If
there be more than one tenant, the obligations imposed by this Lease upon Tenant shall be joint and several. 

  
 19 

 WITNESS the execution hereof under seal on the day and year first above written: 

 

	
	 Landlord:

	
	 /s/

	 As Trustee, but not individually

	
	 /s/

	 As Trustee, but not individually

	
	 Tenant:

	 INFRAREDX, INC.

	
	 /s/ James E. Muller, M.D.

	 By: James E. Muller, M.D.

	 Its: President and CEO

  
 20 

 EXHIBIT A 

PLAN SHOWING THE PREMISES 
  

 

 EXHIBIT B 

RULES AND REGULATIONS 
  

	1.	The sidewalks, entrances, passages, corridors, vestibules, halls, elevators, or stairways in or about the Building shall not be obstructed by Tenant. 

 

	2.	Tenant shall not place objects against glass partitions, doors or windows which would be unsightly from the Building corridor or from the exterior of the Building. 

 

	3.	Tenant shall not waste electricity or water in the Building premises and shall cooperate fully with Landlord to assure the most effective operation of the Building heating and air conditioning systems. All regulating
and adjusting of heating and air-conditioning apparatus shall be done by the Landlord’s agents or employees. 

  

	4.	Tenant shall not use the Premises so as to cause any increase above normal insurance premiums on the Building. 

  

	5.	No bicycles, vehicles, or animals of any kind shall be brought into or kept in or about the Premises. No space in the Building shall be used for the sale of merchandise of any kind at auction or for storage thereof
preliminary to such sale. 

  

	6.	Tenant shall cooperate with Landlord in minimizing loss and risk thereof from fire and associated perils. 

  

	7.	The water and wash closets and other plumbing fixtures shall not be used for any purposes other than those for which they were designed and constructed and no sweepings, rubbish, rags, acid or like substance shall be
deposited therein. All damages resulting from any misuse of the fixtures shall be borne by the Tenant. 

  

	8.	Landlord reserves the right to establish, modify, and enforce reasonable parking rules and regulations, provided such rules and obligations do not diminish Tenant’s rights under the Lease. 

 

	9.	Landlord reserves the right at any time to rescind, alter or waive any rule or regulation at any time prescribed for the Building and to impose additional reasonable rules and regulations when in its judgment deems it
necessary, desirable or proper for its best interest and for the best interest of the tenants and no alteration or waiver of any rule or regulation in favor of one tenant shall operate as an alteration or waiver in favor of any other tenant,
provided such rules and regulations do not diminish Tenant’s rights under the Lease. Landlord shall not be responsible to any tenant for the nonobservance or violation by any other tenant however resulting of any rules or regulations at any
time prescribed for the Building. 

  

	10.	Tenant acknowledges that the Building has been designated a non-smoking building. At no time shall Tenant permit its agents, employees, contractors, guests or invitees to smoke in the Building or, except in specified
locations, directly outside the Building. 

  
 21 

 EXHIBIT C 

DESCRIPTION OF BUILDING EXTERIOR WORK 

The scope of the building exterior work will be the renovation of the building facade fronting Third Avenue generally in accordance with the architectural
rendering depicted below. 
  
 

 

 EXHIBIT D 

TENANT ESTOPPEL CERTIFICATE 
  

	TO:	                         (“Mortgagee” or “Purchaser”) 

THIS IS TO CERTIFY THAT: 
  

	1.	The undersigned is the tenant (the “Tenant”) under that certain lease (the “Lease”) dated             , 20    , by and
between             as landlord (the “Landlord”), and the undersigned, as Tenant, covering those certain premises commonly known and designated as
            (the “Premises”) in the building located at             ,
            , Massachusetts. 

  

	2.	The Lease is attached hereto as Exhibit A and (i) constitutes the entire agreement between the undersigned and the Landlord with respect to the Premises, (ii) is the only Lease between the undersigned and the
Landlord affecting the Premises and (iii) has not been modified, changed, altered or amended in any respect, except (if none, so state): 

  

			
	 	  	
	 	  	
	 	  	

  

	3.	The undersigned has accepted and now occupies the Premises as of the date hereof, and all improvements, if any, required by the terms of the Lease to be made by the Landlord have been completed and all construction
allowances to be paid by Landlord have been paid. In addition, the undersigned has made no agreement with Landlord or any agent, representative or employee of Landlord concerning free rent, partial rent, rebate of rental payments or any other type
of rental or other economic inducement or concession except (if none, so state): 

  

			
	 	  	
	 	  	
	 	  	

  

	4.	

  

	 	(1)	The term of the Lease began (or is scheduled to begin) on             , 20            and will
expire on             , 20    , 

  

	 	(2)	The fixed rent for the Premises has been paid to and including             , 20    ; 

 

	 	(3)	The fixed rent being paid pursuant to the Lease is at the annual rate of $            ; and 

 

	 	(4)	The escalations payable by Tenant under the Lease are currently $            , based on a pro rata share of
            %, and have been reconciled through             , 20    . 

 

	5.	(i) No party to the Lease is in default, (ii) the Lease is in full force and effect, (iii) the rental payable under the Lease is accruing to the extent therein provided thereunder, (iv) as of the date
hereof the undersigned has no charge, lien or claim of off-set (and no claim for any credit or deduction) under the Lease or otherwise, against rents or other charges due or to become due thereunder or on account of any prepayment of rent more than
one (1) month in advance of its due date, and (v) Tenant has no claim against Landlord for any security, rental, cleaning or other deposits, except (if none, so state): 

 

			
	 	  	
	 	  	
	 	  	

  

	6.	Since the date of the Lease there are no actions, whether voluntary or otherwise, pending against the undersigned under the bankruptcy, reorganization, arrangement, moratorium or similar laws of the United States, any
state thereof of any other jurisdiction. 

  

	7.	Tenant has not sublet, assigned or hypothecated or otherwise transferred all or any portion of Tenant’s leasehold interest. 

  

	8.	Neither Tenant nor Landlord has commenced any action or given or received any notice for the purpose of terminating the Lease, nor does Tenant have any right to terminate the Lease, except (if none, so state):

  

	9.	Tenant has no option or preferential right to purchase all or any part of the Premises (or the real property of which the Premises are a part) nor any right or interest with respect to the Premises or the real property
of which the Premises are a part. Tenant has no right to renew or extend the term of the Lease or expand the Premises except (if none, so state): 

  

	10.	The undersigned acknowledges that the parties named herein are relying upon this estoppel certificate and the accuracy of the information contained herein in making a loan secured by the Landlord’s interest in the
Premises, or in connection with the acquisition of the Property of which the Premises is a part. 

  
 22 

 EXECUTED UNDER SEAL AS OF
            , 20    . 
  

			
	TENANT:
	
	 
		
	 By:
	 	 
	 Name:
	 	
	 Title:
	 	
	 Duly
	 	 Authorized

  
 23 

 EXHIBIT E 

FORM OF LETTER OF CREDIT 
  

					
	BENEFICIARY:	 		  	ISSUANCE DATE:
                                        ,
            
			
		 		  	IRREVOCABLE STANDBY
		 		  	LETTER OF CREDIT NO. _________________
			
	ACCOUNTEE/APPLICANT:	 		  	MAXIMUM/AGGREGATE
		 		  	CREDIT AMOUNT:
	 	 		  	USD $________________________
	 	 		  	
	 	 		  	

 GENTLEMEN: 
 We hereby establish
our irrevocable letter of credit in your favor for account of the applicant up to an aggregate amount not to exceed             US Dollars
($            ) available by your draft(s) drawn on ourselves at sight accompanied by: 

Your statement, signed by a purportedly authorized officer/official certifying that the Beneficiary is entitled to draw upon this Letter of Credit (in the
amount of the draft submitted herewith) pursuant to Section 4.4 of the lease (the “Lease”) dated             ,
            by and between             , as Landlord, and
            , as Tenant, relating to the premises at             . 

Draft(s) must indicate name and issuing bank and credit number and must be presented at this office. 

You shall have the right to make partial draws against this Letter of Credit, from time to time. 

Except as otherwise expressly stated herein, this Letter of Credit is subject to the “Uniform Customs and Practice for Documentary Credits, International
Chamber of Commerce, Publication No. 500 (1993 Revision).” 
 This Letter of Credit shall expire at our office on
            ,             (the “Stated Expiration Date”). It is a condition of this Letter of Credit that the Stated
Expiration Date shall be deemed automatically extended without amendment for successive one (1) year periods from such Stated Expiration Date, unless at least forty-five (45) days prior to such Stated Expiration Date) or any anniversary
thereof) we shall notify the Beneficiary and the Accountee/Applicant in writing by registered mail (return receipt) that we elect not to consider this Letter of Credit extended for any such additional one (1) year period. 

We engage with you that all drafts drawn under and in compliance with the terms of this letter of credit will be duly honored on presentation to us. 

 

	
	Very truly yours,
	
	Authorized Signatory

  
 24 

 FIRST AMENDMENT OF LEASE 

This Amendment is made and entered into this l6th day of May, 2006 (the “Effective
Date”) by and between the Trustees of N.W. Building 18 Trust (hereinafter referred to as “Landlord”) and InfraRedX, Inc. (hereinafter referred to as “Tenant”). 

BACKGROUND 
 A.
Landlord and Tenant entered into a lease dated August 1, 2005 (the “Lease”) for approximately 12,106 rentable square feet (the “Original Premises”) in the building known as 34 Third Avenue, Burlington, Massachusetts (the
“Building”). 
 B. Tenant now desires to lease the balance of the Building consisting of an additional 14,341 rentable square feet
as shown on Exhibit A-1 attached hereto (the “Additional Premises”), and Landlord has agreed to lease the Additional Premises to Tenant on the terms and conditions contained herein. 

C. The parties also desire to extend the term of the Lease through June 30, 2009. 

NOW THEREFORE, in consideration of the mutual agreements contained herein and for other good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, the parties agree as follows, as of the Effective Date. 
 1. Landlord hereby leases to Tenant,
and Tenant leases from Landlord, the Additional Premises for a term commencing on the Effective Date and continuing through June 30, 2009, unless terminated earlier in accordance with the terms of the Lease. The demise of the Additional
Premises shall be on all the same terms and conditions of the Lease, as amended hereby. In implementation of the foregoing, as of the Effective Date, the Premises specified in Section 1.1 of the Lease shall be increased to be the entire
interior portion of Building, as shown on Exhibit A attached hereto, and the Rentable Floor Area of Premises specified in Section 1.1 shall be increased to 26,447 square feet by the inclusion of the Additional Premises. All references in
the Lease to the “Premises” shall, as of the Effective Date, mean the Original Premises and the Additional Premises. All work which is necessary or desirable to prepare the Additional Premises for Tenant’s use and occupancy shall be
performed by Tenant, at its sole expense, in accordance with the provisions of Section 6.2.5 of the Lease. 
 2. The Additional Premises
will be delivered to Tenant broom-clean and in as-is condition, with the base building systems and equipment servicing the Additional Premises in good working order, and otherwise without any representation or warranty by Landlord as to the
condition of the Additional Premises and without any obligation on the part of Landlord to construct or prepare the Additional Premises, except that Landlord shall, at its expense, install VCT flooring in the rear portion of the Additional Premises
that is currently bare concrete. Such work shall be performed in good and workmanlike manner and in compliance with applicable building codes. The Landlord’s work shall be performed as soon as reasonably practicable after the full execution of
this Amendment in a manner to minimize unreasonable interference with any work in the Additional Premises simultaneously being performed by Tenant, and the parties agree to reasonably cooperate to coordinate the scheduling and performance of each
party’s work in the Additional Premises. 

 3. The term of the Lease with respect to the Original Premises is hereby extended to be
coterminous with the term of the Additional Premises and shall expire on June 30, 2009. Accordingly, the Expiration Date stated in Section 1.1 of the Lease is hereby changed to June 30, 2009. Tenant acknowledges that the provisions of
Section 4.4.2 require any Letter of Credit to remain in effect for at least 45 days after the Expiration Date and agrees to ensure that the final expiration date contained in any Letter of Credit is no earlier than August 15, 2009.
Concurrently with Tenant’s execution of this Amendment, Tenant shall deliver to Landlord an appropriate amendment to the Letter of Credit evidencing the foregoing final expiration date. 

4. Effective as of July 1, 2006 (the “Additional Premises Rent Commencement Date”), Tenant shall be obligated to pay Fixed Rent
for the Additional Premises. Monthly payments shall be made at the same time and in the same manner that Tenant pays Fixed Rent for the Original Premises pursuant to Section 4.1 of the Lease. In implementation of the foregoing, the Annual Fixed
Rent Rate and the Monthly Fixed Rent Rate stated in Section 1.1 of the Lease shall be increased as of the Additional Premises Rent Commencement Date by the addition of the Fixed Rent payable for the Additional Premises, in accordance with the
following schedule: 
  

									
	 PERIOD:
	  	ANNUAL FIXED
RENT RATE:	 	  	MONTHLY FIXED
RENT RATE:	 
	 July 1, 2006 - December 31, 2006
	  	$	168,852.00	  	  	$	14,071.00	  
	 January 1, 2007 - June 30, 2007
	  	$	216,660.00	  	  	$	18,055.00	  
	 July 1, 2007 - June 30, 2009
	  	$	264,456.00	  	  	$	22,038.00	  

 5. Tenant shall be obligated to pay Operating Costs and Taxes for the Additional Premises in accordance with
Sections 4.1.1 and 4.2.3 of the Lease commencing as of the earlier to occur of (i) the Additional Premises Rent Commencement Date, and (ii) Tenant’s use of the Additional Premises for the conduct of its business. 

6. As a result of Tenant’s leasing the entire Building, certain changes must be made to the Lease to convert it from a multi-tenant format
to single-tenant format. Accordingly, the Lease shall be amended as follows, as of the Effective Date: 
  

	 	A.	In Section 1.1, the definition of Premises shall be deleted and the following substituted therefor: 

  

	 	    	“All of the interior space of the Building, substantially as shown on Exhibit A attached hereto.” 

  

	 	B.	In Section 2.1 the Rentable Floor Area of Premises shall be increased to approximately 26,447 square feet. 

  

	 	C.	In Section 1.1 the Tenant’s Percentage shall be increased from 45.8% to 100%. 

  

	 	D.	In Section 2.1, the first full paragraph shall be deleted and the following substituted therefor: 

  

	 	    	 “Landlord hereby leases to Tenant and Tenant hereby leases from Landlord, subject to and with the benefit of the terms, covenants, conditions and
provisions of this Lease, the Premises, excluding, however, the use of the roof of the Building, provided however that in the event that Tenant’s use of the Additional Premises requires

  
 2 

	 	
additional HVAC or exhaust units, Landlord shall not unreasonably withhold its consent to such items being installed on the roof of the Building, provided, however, if in Landlord’s
reasonable judgment, Tenant’s excess requirements or excess use shall require Landlord to make additions or modifications to the base building HVAC systems resulting in additional cost to Landlord on account thereof, Tenant shall, upon demand,
reimburse Landlord for such additional cost. Tenant shall have, as appurtenant to the Premises, rights to use (a) the walkways and driveways necessary for access to the Building, and (b) the parking areas serving the Building.”

  

	 	E.	In Section 2.1, the second paragraph (regarding parking) shall be amended by deleting the words, “up to 59” and inserting the words “all of the” in their place. 

 

	 	F.	In Section 2.1, the third paragraph shall be amended by deleting existing clause (b) therefrom, and changing existing clauses (c) and (d) to be identified as (b) and (c), respectively.

  

	 	G.	In Section 4.2.4, the following shall be inserted at the end thereof: “For the sake of clarity, in no event shall Tenant be required to carry all risk property and casualty insurance on the Building, it being
acknowledged and agreed that it shall be Landlord’s sole responsibility to do so.” 

  

	 	H.	In Section 4.2.3, the second paragraph, containing the definition of “Operating Costs,” shall be amended by deleting the following phrase “all costs related to provision of heat (including oil,
electric, steam and/or gas), air-conditioning, and water (including sewer charges) and other utilities to the Building (exclusive of reimbursement to Landlord of any of the same received as a result of direct billing to any tenant of the
Building);” and substituting in its place the phrase “all costs related to the provision of water (including sewer charges) to the Building;”. In addition, the last full paragraph of said Section 4.2.3 shall be deleted in its
entirety. 

  

	 	I.	Section 4.2.5 shall be deleted and the following shall be substituted therefor: 

  

	 	    	“Tenant shall pay directly to the proper authorities charged with the collection thereof all charges for gas, electricity, telephone and other utilities or services used or consumed on the Premises, including
electricity for lighting in the parking area serving the Building, whether designated as a charge, tax, assessment, fee or otherwise, all such charges to be paid as the same from time to time become due. It is understood and agreed that Tenant shall
make its own arrangements for the installation or provision of all such utilities and that Landlord shall be under no obligation to furnish any utilities to the Premises and shall not be liable for any interruption or failure in the supply of any
such utilities to the Premises. All charges for water and sewer shall be paid for by Tenant as part of Operating Costs pursuant to Section 4.2.3 above.” 

 

	 	J.	Section 5.1.5 shall be amended by deleting the phrase “common areas” from the third line thereof. 

7. In addition to Tenant’s obligations set forth in Section 6.1.9 of the Lease to restore the Premises at the end of the Lease term,
Tenant shall be obligated at the expiration or earlier termination of the Lease to remove any installations or alterations made by Tenant to the Additional Premises that 

  
 3 

 
are not customary for office and research and development space, and shall restore the Additional Premises to an open-office configuration as shown on Exhibit A-1, if requested by Landlord. In
the event Tenant elects to reinstall the loading dock in the Additional Premises, Tenant will not be required to remove the same at the end of the Lease term. 

8. As of the Effective Date, (i) Exhibit A attached hereto shall be substituted for Exhibit A attached to the Lease;
(ii) Section 2.4 and Article 3 of the Lease shall have no further force or effect; and (iii) the term “Rent Commencement Date” specified in Section 1.1 shall have no applicability to nor force or effect with respect to
the Additional Premises. 
 9. Tenant represents and warrants to Landlord that it has dealt with no broker in connection with the
consummation of this Amendment, other than Nordblom Brokerage Company and The Staubach Company (collectively, the `Brokers”), and in the event of any brokerage claims, other than by the Brokers, against Landlord predicated upon prior dealings
with Tenant, Tenant agrees to defend the same and indemnify and hold Landlord harmless against any such claim. 
 10. All undefined
capitalized terms used herein without definition shall have the meanings ascribed to them in the Lease. The recitals set forth above are incorporated into this Amendment. 

As amended hereby, the Lease is ratified and confirmed in all respects and shall continue in full force and effect. 

Executed as a Massachusetts instrument under seal as of the date first set forth above. 

 

	
	LANDLORD:
	
	/s/
	As Trustee of N.W. Building
	18 Trust and not individually
	
	/s/
	As Trustee of N.W. Building
	18 Trust and not individually
	
	TENANT:
	INFRAREDX, INC.
	
	/s/ Andrew R. Jordan
	By: Andrew R. Jordan
	Title: CBO/CFO
	Hereto duly authorized

  
 4 

 EXHIBIT A 

PREMISES 
 26,447 SF

  
 

 

  
 5 

 EXHIBIT A-1 

ADDITIONAL PREMISES 
  

 

  
 6 

 SECOND AMENDMENT OF LEASE 

This Amendment is made and entered into this 30th day of June, 2008 (the “Effective
Date”) by and between the Trustees of N.W. Building 18 Trust (hereinafter referred to as “Landlord”) and InfraRedX, Inc. (hereinafter referred to as “Tenant”). 

WITNESSETH: 

WHEREAS, Landlord and Tenant entered into a lease dated August 1, 2005 as amended by the First Amendment of Lease dated May 16, 2006
(the “Lease”) for approximately 26,447 rentable square feet (the “Premises”) in the building known as 34 Third Avenue, Burlington, Massachusetts (the “Building”). 

WHEREAS, Landlord and Tenant desire to modify a certain provision of the Lease. 

NOW, THEREFORE, for valuable consideration, the Lease is hereby modified and amended as follows: 

1. Section 2.3 shall be deleted and the following shall be substituted therefore: 

“Provided that as of the date of the notice specified below, Tenant is not in default and has not previously been in default of its obligations under
this Lease beyond any applicable grace period, Tenant shall have the right to extend the term of this Lease for one additional period of four (4) years, to begin immediately upon the expiration of the original term of this Lease (the
“extended term”). All of the terms, covenants and provisions of this Lease shall apply to such extended term except that the Annual Fixed Rent Rate for such extension period shall be the market rate for comparable buildings in the Town of
Burlington, Massachusetts at the commencement of such extended term, as designated by Landlord. If Tenant shall elect to exercise the aforesaid option, it shall do so by giving Landlord notice in writing of its intention to do so not later than nine
(9) months prior to the expiration of the original term of this Lease. If Tenant gives such notice, the extension of this Lease shall be automatically effected without the execution of any additional documents. The original term and the
extended term are hereinafter collectively called the “term”. 
 If Tenant exercises the aforesaid option, then not later than eight
(8) months prior to the expiration of the original term of this Lease Landlord shall give written notice to Tenant of Landlord’s designation of the market rate. Within fifteen (15) days following Landlord’s notice, Tenant shall
either propose its designation of the market rate by giving notice thereof to Landlord or shall accept Landlord’s designation. Failure on the part of Tenant to give such notice of its designation shall bind Tenant to Landlord’s
designation. If Tenant proposes its designation of the market rate, then Landlord and Tenant shall attempt to agree upon a market rate. If the parties have been unable to reach agreement within thirty (30) days following Tenant’s
designation, then the market rate may be submitted to arbitration by either party as follows: market rate shall be determined by 

 
impartial arbitrators, one to be chosen by the Landlord, one to be chosen by Tenant, and a third to be selected, if necessary, as below provided. The unanimous written decision of the two first
chosen, without selection and participation of a third arbitrator, or otherwise, the written decision of a majority of three arbitrators chosen and selected as aforesaid, shall be conclusive and binding upon Landlord and Tenant. Landlord and Tenant
shall each notify the other of its chosen arbitrator within ten (10) clays following the call for arbitration and, unless such two arbitrators shall have reached a unanimous decision within thirty (30) days after their designation, they
shall so notify the then ?resident of the Boston Bar Association and request him to select an impartial third arbitrator, who shall be another office building owner, a real estate counselor or a broker dealing with. like types of properties, to
determine market rate as herein defined. Such third arbitrator and the first two chosen shall hear the parties and their evidence and render their decision within thirty (30) days following the conclusion of such hearing and notify Landlord and
Tenant thereof. Landlord and Tenant shall share equally the expense of the third arbitrator (if any). If the dispute between the parties as to a market rate has not been resolved before the commencement of Tenant’s obligation to pay Fixed Rent
based upon such market rate, then Tenant shall pay Fixed Rent under the Lease based upon the market rate designated by Landlord until either the agreement of the parties as to the market rate, or the decision of the arbitrators, as the case may be,
at which time Tenant shall pay any underpayment of Fixed Rent to Landlord, or Landlord shall refund any overpayment of Fixed Rent to Tenant. 

In any event, the Annual Fixed Rent Rate for the extended term shall not be less than the Annual Fixed Rent Rate in effect immediately prior
to such extended term.” 
 INTENTIONALLY LEFT BLANK 

 As amended hereby, the Lease is ratified and confirmed in all respects and shall continue in full
force and effect. 
 Executed as a Massachusetts instrument under seal as of the date first set forth above. 

 

	
	LANDLORD:
	
	/s/ John D. Macomber
	As Trustee of N.W. Building
	18 Trust and not individually
	
	/s/ Peter C. Nordblom
	As Trustee of N.W. Building
	18 Trust and not individually
	
	TENANT:
	INFRAREDX, INC.
	
	/s/ Andrew R. Jordan
	By: Andrew R. Jordan
	Title: CBO/CFO
	Hereto duly authorized

 THIRD AMENDMENT OF LEASE 

This Amendment is made and entered into this 2nd day of October, 2008 (the
“Effective Date”) by and between the Trustees of N.W. Building 18 Trust (hereinafter referred to as “Landlord”) and InfraReDx, Inc. (hereinafter referred to as “Tenant”). 

WITNESSETH: 

WHEREAS, Landlord and Tenant entered into a lease dated August 1, 2005 as amended by the First Amendment of Lease dated May 16,
2006, as amended by the Second Amendment of Lease dated June 30, 2008 (collectively the “Lease”) for approximately 26,447 rentable square feet (the “Premises”) in the building known as 34 Third Avenue, Burlington,
Massachusetts (the `Building”). 
 NOW THEREFORE, for good and valuable consideration, the Lease is hereby amended as follows: 

1. The term of the Lease is hereby extended for an additional period of three (3) years (the “Extended Term”). Accordingly, the
definition of Expiration Date specified in Section 1.1 is changed to “June 30, 2012”. 
 2. Effective as of the commencement
of the Extended Term, the Annual Fixed Rent Rate and Monthly Fixed Rent Rate specified in Section 1.1 shall be modified as follows: 
  

							
	 Annual Fixed Rent Rate:
	  	 July 1, 2009 - June 30, 2010:

July 1, 2010 - June 30, 2011:

July 1, 2011 - June 30, 2012:
	  	$
 $
 $
	333,228.00
 346,452.00

359,676.00
	  
   

  

	 Monthly Fixed Rent Rate:
	  	 July 1, 2009 - June 30, 2010:

July 1, 2010 - June 30, 2011:

July 1, 2011 - June 30, 2012:
	  	$
 $
 $
	27,769.00
 28,871.00

29,973.00
	  
   

  

 3. Section 2.3 shall be deleted and the following shall be substituted therefore: 

“Provided that as of the date of the notice specified below, Tenant is not in default and has not previously been in default of its obligations under
this Lease beyond any applicable grace period, Tenant shall have the right to extend the term of this Lease for one additional period of one (1) year, to begin immediately upon the expiration of the original term of this Lease (the “Option
Term”). All of the terms, covenants and provisions of this Lease shall apply to such Option Term except that the Annual Fixed Rent Rate for such extension period shall be the market rate for comparable buildings in the Town of Burlington,
Massachusetts at the commencement of such Option Term, as designated by Landlord. If Tenant shall elect to exercise the aforesaid option, it shall do 

 
so by giving Landlord notice in writing of its intention to do so not later than twelve (12) months prior to the expiration of the Extended Term of this Lease. If Tenant gives such notice,
the extension of this Lease shall be automatically effected without the execution of any additional documents. The original term, the Extended Term and the Option Term are hereinafter collectively called the “term”. 

If Tenant exercises the aforesaid option, then not later than eight (8) months prior to the expiration of the original term of this Lease Landlord shall
give written notice to Tenant of Landlord’s designation of the market rate. Within fifteen (15) days following Landlord’s notice, Tenant shall either propose its designation of the market rate by giving notice thereof to Landlord or
shall accept Landlord’s designation. Failure on the part of Tenant to give such notice of its designation shall bind Tenant to Landlord’s designation. If Tenant proposes its designation of the market rate, then Landlord and Tenant shall
attempt to agree upon a market rate. If the parties have been unable to reach agreement within thirty (30) days following Tenant’s designation, then the market rate may be submitted to arbitration by either party as follows: market rate
shall be determined by impartial arbitrators, one to be chosen by the Landlord, one to be chosen by Tenant, and a third to be selected, if necessary, as below provided. The unanimous written decision of the two first chosen, without selection and
participation of a third arbitrator, or otherwise, the written decision of a majority of three arbitrators chosen and selected as aforesaid, shall be conclusive and binding upon Landlord and Tenant. Landlord and Tenant shall each notify the other of
its chosen arbitrator within ten (10) days following the call for arbitration and, unless such two arbitrators shall have reached a unanimous decision within thirty (30) days after their designation, they shall so notify the then President
of the Boston Bar Association and request him to select an impartial third arbitrator, who shall be another office building owner, a real estate counselor or a broker dealing with like types of properties, to determine market rate as herein defined.
Such third arbitrator and the first two chosen shall hear the parties and their evidence and render their decision within thirty (30) days following the conclusion of such hearing and notify Landlord and Tenant thereof. Landlord and Tenant
shall share equally the expense of the third arbitrator (if any). If the dispute between the parties as to a market rate has not been resolved before the commencement of Tenant’s obligation to pay Fixed Rent based upon such market rate, then
Tenant shall pay Fixed Rent under the Lease based upon the market rate designated by Landlord until either the agreement of the parties as to the market rate, or the decision of the arbitrators, as the case may be, at which time Tenant shall pay any
underpayment of Fixed Rent to Landlord, or Landlord shall refund any overpayment of Fixed Rent to Tenant. 
 In any event, the Annual Fixed Rent Rate for
the Option Term shall not be less than the Annual Fixed Rent Rate in effect immediately prior to such Option Term.” 
 4. Prior to
July 1, 2009, Landlord, at its cost, will install a new, 5-ton, HVAC system to service the offices on the south-west side of the building (from the President’s office to the reception area) and will also repair the floor drain in the
ladies bathroom. 

 5. Capitalized terms used herein without definition shall have the meanings ascribed to them in
the Lease. 
 As amended hereby, the Lease is ratified and confirmed in all respects, and shall continue in full force and effect. 

Executed as a Massachusetts instrument under seal as of the date first set forth above. 

 

	
	LANDLORD:
	
	/s/
	As Trustee of N.W. Building
	18 Trust and not individually
	
	/s/
	As Trustee of N.W. Building
	18 Trust and not individually
	
	TENANT:
	INFRAREDX, INC.
	
	/s/
	By:
	Title: President & COO
	Hereto duly authorized

 FOURTH AMENDMENT OF LEASE 

This Amendment is made and entered into this 6th day of August, 2012 (the “Effective Date”) by and between NWP Building 18 LLC,
successor in interest to N.W. Building 18 Trust, (hereinafter referred to as “Landlord”) and InfraReDx, Inc. (hereinafter referred to as “Tenant”). 

WITNESSETH: 

WHEREAS, Landlord and Tenant entered into a lease dated August 1, 2005 as amended by the First Amendment of Lease dated May 16,
2006, as amended by the Second Amendment of Lease dated June 30, 2008, as amended by the Third Amendment of Lease dated October 2, 2008 and the notice of intent dated June 30, 2011 extending the lease until June 30, 2013
(collectively the “Lease”) for approximately 26,447 rentable square feet (the “Premises”) in the building known as 34 Third Avenue, Burlington, Massachusetts (the “Building”). 

NOW THEREFORE, for good and valuable consideration, the Lease is hereby amended as follows: 

1. The term of the Lease is hereby extended for an additional period of one (1) year and six (6) months (the “Extended
Term”). Accordingly, the definition of Expiration Date specified in Section 1.1 is changed to “December 31, 2014”. 
 2.
Effective as of the commencement of the Extended Term, the Annual Fixed Rent Rate and Monthly Fixed Rent Rate specified in Section 1.1 shall be modified as follows: 
  

					
	 Annual Fixed Rent Rate:

July 1, 2013 – December 31, 2014:
	  	$	317,364.00	  
	 Monthly Fixed Rent Rate:

July 1, 2013 – December 31, 2014:
	  	$	26,447.00	  

 3. Section 2.3 is hereby deleted. 

4. The Premises are leased to Tenant during the Extended Term in its then “as-is” condition. 

5. Capitalized terms used herein without definition shall have the meanings ascribed to them in the Lease. 

 6. Tenant represents and warrants to Landlord that it has dealt with no broker in connection with
the consummation of this Amendment, and in the event of any brokerage claims against Landlord predicated upon prior dealings with Tenant, Tenant agrees to defend the same and indemnify and hold Landlord harmless against any such claim. 

As amended hereby, the Lease is ratified and confirmed in all respects, and shall continue in full force and effect. 

Executed as a Massachusetts instrument under seal as of the date first set forth above. 

 

			
	LANDLORD:
	
	 NWP Building 18 LLC,
 a
Massachusetts limited liability company

		
	By:	 	/s/ Adele Olivier
	Name:	 	Adele Olivier
	Title:	 	Manager
		
	By:	 	/s/ John D. Macomber
	Name:	 	John D. Macomber
	Title:	 	Manager
		
	By:	 	/s/ Peter C. Nordblom
	Name:	 	Peter C. Nordblom
	Title:	 	Manager
		
	By:	 	/s/
	Name:	 	
	Title:	 	Manager
	
	TENANT:
	INFRAREDX, INC.
	
	/s/ Donald Southard
	By: Donald Southard
	Title: CEO
	Hereto duly authorized

 FIFTH AMENDMENT OF LEASE 

This Amendment is made and entered into this 24th day of February, 2014 (the “Effective Date”) by and between NWP Building 18 LLC,
successor in interest to N.W. Building 18 Trust, (hereinafter referred to as “Landlord”) and InfraReDx, Inc. (hereinafter referred to as “Tenant”). 

WITNESSETH: 

WHEREAS, Landlord and Tenant entered into a lease dated August 1, 2005 as amended by the First Amendment of Lease dated May 16,
2006, as amended by the Second Amendment of Lease dated June 30, 2008, as amended by the Third Amendment of Lease dated October 2, 2008 and the notice of intent dated June 30, 2011 extending the lease until June 30, 2013, as
amended by the Fourth Amendment of Lease dated August 6th, 2012 (collectively the “Lease”) for approximately 26,447 rentable square feet (the “Premises”) in the building
known as 34 Third Avenue, Burlington, Massachusetts (the “Building”). 
 NOW THEREFORE, for good and valuable consideration, the
Lease is hereby amended as follows: 
 1. The term of the Lease is hereby extended for an additional period of one (1) year (the
“Extended Term”). Accordingly, the definition of Expiration Date specified in Section 1.1 is changed to “December 31, 2015”. 

2. Effective as of the commencement of the Extended Term, the Annual Fixed Rent Rate and Monthly Fixed Rent Rate specified in Section 1.1
shall be modified as follows: 
  

					
	 Annual Fixed Rent Rate:

January 1, 2015 – December 31, 2015:
	  	$	343,800.00	  
	 Monthly Fixed Rent Rate:

January 1, 2015 – December 31, 2015:
	  	$	28,650.00	  

 3. Effective as of the commencement of the Extended Term, the second paragraph in Section 2.1 (regarding
parking) shall be amended by deleting the paragraph and replacing it as follows: 
 “At no additional charge during the term, Tenant
shall have the non-exclusive right to use all of the parking spaces in the parking area serving the building.” 

 4. The Premises are leased to Tenant during the Extended Term in its then “as-is”
condition. 
 5. Capitalized terms used herein without definition shall have the meanings ascribed to them in the Lease. 

6. Tenant represents and warrants to Landlord that it has dealt with no broker in connection with the consummation of this Amendment, and in
the event of any brokerage claims against Landlord predicated upon prior dealings with Tenant, Tenant agrees to defend the same and indemnify and hold Landlord harmless against any such claim. 

As amended hereby, the Lease is ratified and confirmed in all respects, and shall continue in full force and effect. 

Executed as a Massachusetts instrument under seal as of the date first set forth above. 

 

			
	LANDLORD:
	
	 NWP Building 18 LLC,
 a
Massachusetts limited liability company

		
	By:	 	/s/ Adele Olivier
	Name:	 	Adele Olivier
	Title:	 	Manager
		
	By:	 	/s/ Peter C. Nordblom
	Name:	 	Peter C. Nordblom
	Title:	 	Manager
		
	By:	 	/s/ John D. Macomber
	Name:	 	John D. Macomber
	Title:	 	Manager
	
	TENANT:
	INFRAREDX, INC.
	
	/s/ Don Southard
	By: Don Southard
	 Title: Chief Executive Officer

Hereto duly authorized

 Memorandum 
  

			
	To:	  	Peter Nordblom / John Macomber / Adele Olivier
		
	From:	  	Patrick DiGregorio
		
	Date:	  	March 3, 2014
		
	Re:	  	InfraReDx, Inc. Fifth Amendment of Lease

 Hello, 
 Attached for your
signatures are two original documents as referenced above. 
 We have been discussing extension options with this tenant, including an expansion into the
Thoratec space at building 20. Terms ranged from 3 to 5 years. 
 The approval process necessary in order to enter the Japanese market is taking longer than
expected. Therefore, they cannot commit to any significant term at the moment. 
 In the end, we agreed that a one-year extension is best for both parties
at this point in time. 
 We will continue to talk about their space needs over the coming year as the overseas approval process evolves. 

The Fixed Rent is $13 psf. 
 There is no TI, nor was there an
outside broker on this deal. 
 Please sign where indicated and return them to me at your convenience. 

Thank You 

  
 1 

 Memorandum 

			
		
	To:	  	Peter Nordblom, Adele Olivier, John Macomber
		
	From:	  	Patrick DiGregorio
		
	Date:	  	November 12, 2014
		
	Re:	  	InfraReDx Sixth Amendment

 Hello, 
 Attached for your
signatures are three (3), original, documents as referenced above. 
 This amendment serves to extend the tenant’s lease for one year, making the new
expiration date December 31, 2016. 
 This extension is “as-is”, with no outside broker, and a net rental rate of $13.50psf. 

Please sign where indicated and return to me at your convenience. 

Thank You 

  
 1 

 SIXTH AMENDMENT OF LEASE 

This Amendment is made and entered into this 10th day of November, 2014 (the “Effective Date”) by and between NWP Building 18 LLC,
successor in interest to N.W. Building 18 Trust, (hereinafter referred to as “Landlord”) and InfraReDx, Inc. (hereinafter referred to as “Tenant”). 

WITNESSETH: 

WHEREAS, Landlord and Tenant entered into a lease dated August 1, 2005 as amended by the First Amendment of Lease dated May 16,
2006, as amended by the Second Amendment of Lease dated June 30, 2008, as amended by the Third Amendment of Lease dated October 2, 2008 and the notice of intent dated June 30, 2011 extending the lease until June 30, 2013, as
amended by the Fourth Amendment of Lease dated August 6th, 2012, as amended by the Fifth Amendment of Lease dated February 24, 2014 (collectively the “Lease”) for approximately 26,447 rentable square feet (the
“Premises”) in the building known as 34 Third Avenue, Burlington, Massachusetts (the “Building”). 
 NOW THEREFORE, for
good and valuable consideration, the Lease is hereby amended as follows: 
 1. The term of the Lease is hereby extended for an additional
period of one (1) year (the “Extended Term”). Accordingly, the definition of Expiration Date specified in Section 1.1 is changed to “December 31, 2016”. 

2. Effective as of the commencement of the Extended Term, the Annual Fixed Rent Rate and Monthly Fixed Rent Rate specified in Section 1.1
shall be modified as follows: 
  

					
	 Annual Fixed Rent Rate:

January 1, 2016 – December 31, 2016:
	  	$	357,036.00	  
	 Monthly Fixed Rent Rate:

January 1, 2016 – December 31, 2016:
	  	$	29,753.00	  

 3. The Premises are leased to Tenant during the Extended Term in its then “as-is” condition. 

4. Capitalized terms used herein without definition shall have the meanings ascribed to them in the Lease. 

 5. Tenant represents and warrants to Landlord that it has dealt with no broker in connection with
the consummation of this Amendment, and in the event of any brokerage claims against Landlord predicated upon prior dealings with Tenant, Tenant agrees to defend the same and indemnify and hold Landlord harmless against any such claim. 

As amended hereby, the Lease is ratified and confirmed in all respects, and shall continue in full force and effect. 

Executed as a Massachusetts instrument under seal as of the date first set forth above. 

 

			
	LANDLORD:
	
	 NWP Building 18 LLC,
 a
Massachusetts limited liability company

		
	By:	 	/s/ Adele Olivier
	Name:	 	Adele Olivier
	Title:	 	Manager
		
	By:	 	/s/ John D. Macomber
	Name:	 	John D. Macomber
	Title:	 	Manager
		
	By:	 	/s/ Peter C. Nordblom
	Name:	 	Peter C. Nordblom
	Title:	 	Manager
	
	TENANT:
	INFRAREDX, INC.
	
	/s/ Don Southard
	By: Don Southard
	Title: Chief Executive Officer
	Hereto duly authorized

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