Document:

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                                                                   Exhibit 10.11

                              EMPLOYMENT AGREEMENT

         THIS EMPLOYMENT AGREEMENT ("Agreement") is made and entered into as of
January 2, 2002 (the "Effective Date"), by and between ADERIS PHARMACEUTICALS,
INC., a Delaware corporation (the "Company"), and Kenneth L. Rice Jr.
("Executive").

AGREEMENT

1.       EMPLOYMENT

         The Company hereby employs Executive and Executive hereby accepts
employment upon the terms and conditions set forth below.

2.       TERM AND RENEWAL

         2.1      Term. The term of this Agreement shall commence on the
Effective Date, and shall continue for two (2) years from the Effective Date
(the "Original Employment Term"), on the terms and conditions set forth below,
unless sooner terminated as provided in Section 5.

         2.2      Extension. Following the expiration of the Original Employment
Term and provided that this Agreement has not been terminated pursuant to
Section 5, and every year thereafter, the Agreement shall be automatically
renewed for an additional 12 month period (the "Extension Period"), effective on
each anniversary date of the Effective Date, unless either party notifies the
other party in writing not less than 30 days prior to the expiration of the
Original Employment Term or any subsequent 12 month period.

3.       COMPENSATION

         3.1      Base Compensation. For the services to be rendered by
Executive under this Agreement, Executive shall be entitled to receive an
initial annual base compensation ("Base Compensation") of $225,000, payable in
substantially equal bi-weekly installments. Thereafter, the Base Compensation
shall be reviewed and adjusted annually as recommended by the Compensation
Committee (the "Compensation Committee") and approved by the Board of Directors
(the "Board") of the Company, or if there is no Compensation Committee, then by
the Board; provided, however, in no event may the Base Compensation be adjusted
below the initial annual Base Compensation set forth in this Section 3.1.

         3.2      Bonus Compensation. The Compensation Committee shall review
Executive's performance at least annually during each year of the Original
Employment Term and during any periods of automatic extension of this Agreement
pursuant to Section 2.2. The Compensation Committee shall recommend and the
Board shall approve and authorize the Company to award Executive a cash bonus
which shall reasonably be determined as fairly compensating and rewarding
Executive for services rendered to the Company and/or as an incentive for
continued service to the Company. The amount of such cash bonus shall be
determined in the sole and absolute discretion of the Board based upon the
recommendation of the Compensation Committee, shall be dependent on, among other
things, the achievement of certain performance

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levels by the Company, including, growth in funds from operations, and
Executive's performance and contribution to increasing the funds from
operations.

         3.3      Benefits.

                  (a) Medical Insurance. The Company shall provide to Executive
and Executive's spouse and children, at its sole cost, such health, dental and
optical insurance as the Company may from time to time make available to its
other executive employees.

                  (b) Life and Disability Insurance. The Company shall provide
Executive such disability and life insurance as the Company in its sole
discretion may from time to time make available to its other executive
employees.

                  (c) Pension Plans, Etc. Executive shall be entitled to
participate in all pension, 401(k) and other employee plans and benefits
established by the Company on at least the same terms as the Company's other
executive employees.

         3.4      Vacation. Executive shall be entitled to four (4) vacation
weeks (20 business days) in each calendar year, subject to and on a basis
consistent with Company policy. In addition, Executive shall be entitled to all
Company holidays.

4.       POSITION AND DUTIES

         4.1      Position. Executive shall serve as Vice President, Chief
Commercial Officer & In-house Counsel. The Company agrees that the duties that
may be assigned Executive shall be the usual and customary duties of the offices
of Vice President, Chief Commercial Officer & In-house Counsel. Executive shall
have such executive power and authority as shall reasonably be required to
enable Executive to discharge the duties of such offices. At the Company's
request, Executive may, at Executive's discretion, serve the Company and its
respective subsidiaries in other offices and capacities in addition to the
foregoing, but shall not be required to do so. In the event the Company and
Executive mutually agree that Executive shall terminate Executive's service in
any one or more of the aforementioned capacities, or Executive's service in one
or more of the aforementioned capacities is terminated, Executive's
compensation, as specified in this Agreement, shall not be diminished or reduced
in any manner.

         4.2      Devotion of Time and Effort. Executive shall use Executive's
good faith best efforts and judgment in performing Executive's duties as
required hereunder and to act in the best interests of the Company. Executive
shall devote substantially all of his business time and attention to the
performance of services of the Company in his capacity as an officer thereof and
as may reasonably be requested by the Board.

         4.3      Other Activities. Executive may engage in other activities for
Executive's own account while employed hereunder, including, charitable,
community and other business activities, provided that such other activities do
not materially interfere with the performance of Executive's duties hereunder.

         4.4      Business Expenses. The Company shall promptly, but in no event
later than ten days after submission of a claim of expenditure, reimburse
Executive for all reasonable business

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expenses including, business seminar fees, professional association dues, bar
dues and reasonable entertainment expenses incurred by Executive in connection
with the business of the Company, upon presentation to the Company of written
receipts for such expenses. Such reimbursement shall also include, but not be
limited to, reimbursement for all reasonable travel expenses, including all
airfare, hotel and rental car expenses incurred by Executive in travelling in
connection with the business of the Company.

         4.5      Company's Obligations. The Company shall provide Executive
with any and all necessary or appropriate current financial information and
access to current information and records regarding all material transactions
involving the Company, including but not limited to acquisition of assets,
personnel contracts, dispositions of assets, service agreements and registration
statements or other state or federal filings or disclosures, reasonably
necessary for Executive to carry out Executive's duties and responsibilities
hereunder. In addition, the Company agrees to provide Executive, as a condition
to Executive's services hereunder, such staff, equipment and office space as is
reasonably necessary for Executive to perform Executive's duties hereunder.

5.       TERMINATION

         5.1      By Company Without Cause. The Company may terminate this
Agreement without "cause" (as hereinafter defined) at any time following the
Effective Date, provided that the Company first deliver to Executive the
Company's written election to terminate this Agreement at least 90 days prior to
the effective date of termination.

         5.2      Severance Payment.

                  (a) Amount. In the event the Company terminates Executive's
services hereunder without cause pursuant to Section 5.1 or by Executive
pursuant to Section 5.4 or 5.6, Executive shall continue to render services to
the Company pursuant to this Agreement until the date of termination and shall
continue to receive compensation, as provided hereunder, through the termination
date. In addition to other compensation payable to Executive for services
rendered through the termination date, the Company shall pay Executive no later
than the date of such termination, as a single severance payment, an amount
equal to (i) Executive's highest monthly Base Compensation paid hereunder during
the preceding 12 month period, multiplied by the greater of the number of months
remaining in the employment term (as determined under Section 2 above) measured
from the termination date or 12, plus (ii) one times the average annual bonus
received by the Executive during the preceding twenty-four month period (the
"Severance Amount").

                  (b) Benefits. In the event Executive's employment hereunder is
terminated by the Company without cause pursuant to Section 5.1, by the Company
with cause on account of Executive's Disability (as defined in Section 5.3(d)
hereof), or by Executive pursuant to Section 5.4 or 5.6, then in addition to
paying Executive the Severance Amount, the Company shall continue to provide to
Executive and Executive's spouse and children, as applicable, all of the
benefits described in Section 3.3 for a period equal to the greater of (i) the
remaining term of this Agreement or (ii) one year commencing on the date of such
termination (the "Severance Benefits").

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                  (c) Acceleration of Vesting.

                           (i) In the event Executive's employment hereunder is
terminated by the Company without cause pursuant to Section 5.1, or by Executive
pursuant to Section 5.4 or 5.6, then in addition to paying Executive the
Severance Amount and the Severance Benefits, the vesting of (A) the unvested
portion of any stock option to purchase Company common stock granted to
Executive ("Stock Options") and (B) any shares of Company common stock granted
to Executive which is subject to forfeiture ("Restricted Stock"), shall continue
to vest for a period of (1) one year and, with respect to the vested portion of
any Restricted Stock, shall cease to be subject to forfeiture and, with respect
to the vested portion of any Stock Options, shall be exercisable.

                           (ii) In the event Executive's employment hereunder is
terminated on account of Executive's death, the vesting of (A) the unvested
portion of any stock option to purchase Company common stock granted to
Executive ("Stock Options") and (B) any shares of Company common stock granted
to Executive which is subject to forfeiture ("Restricted Stock"), shall continue
to vest for a period of (1) one year and, with respect to the vested portion of
any Restricted Stock, shall cease to be subject to forfeiture and, with respect
to the vested portion of any Stock Options, shall be exercisable.

         5.3      By the Company For Cause. The Company may terminate Executive
for cause at any time, upon written notice to Executive. For purposes of this
Agreement, "cause" shall mean:

                  (a) Executive's conviction for commission of a felony;

                  (b) Executive's willful commission of any act of theft,
embezzlement or misappropriation against the Company;

                  (c) Executive's willful and continued failure to substantially
perform Executive's duties hereunder (other than such failure resulting from
Executive's incapacity due to physical or mental illness), which failure is not
remedied within a reasonable time after written demand for substantial
performance is delivered by the Company which specifically identifies the manner
in which the Company believes that Executive has not substantially performed
Executive's duties; or

                  (d) Executive's death or Disability (as hereinafter defined).

         In the event Executive is terminated for cause pursuant to this Section
5.3, Executive shall have the right to receive Executive's compensation as
otherwise provided under this Agreement through the effective date of
termination. Executive shall have no further right to receive compensation or
other consideration from the Company or have any other remedy whatsoever against
the Company as a result of this Agreement or the termination of Executive
pursuant to this Section 5.3, except as set forth below with respect to a
termination due to Executive's Disability.

         In the event Executive is terminated by reason of Executive's
Disability (but not death), the Company shall immediately pay Executive a single
severance payment equal to the Severance Amount. Said payment shall be in
addition to any disability insurance payments to

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which Executive is otherwise entitled and any other compensation earned by
Executive hereunder. For purposes of this Agreement, the term "Disability" shall
mean a physical or mental incapacity as a result of which Executive becomes
unable to continue the proper performance of Executive's duties hereunder for
six consecutive calendar months or for shorter periods aggregating 180 business
days in any 12 month period, but only to the extent that such definition does
not violate the Americans with Disabilities Act of 1990.

         5.4      By Executive For Good Reason. Executive may terminate
this Agreement for good reason upon at least 30 days' prior written notice to
the Company. For purposes of this Agreement, "good reason" shall mean:

                           (a) the Company's material breach of any of its
respective obligations hereunder and either such breach is incurable or, if
curable, has not been cured within 30 business days following receipt by the
Company of written notice from Executive to the Company of such breach by the
Company;

                           (b) any material decrease in Executive's authority or
responsibilities as Vice President, Chief Commercial Officer & In-house Counsel
of the Company without Executive's prior written consent; or

                           (c) any decrease in the Base Compensation including
any adjustments under Section 3.1 above or Benefits under Section 3.3 above
payable to Executive by the Company without Executive's prior consent; any
decrease in the Bonus Compensation under Section 3.2 above shall not constitute
good reason; or

     In the event that Executive terminates this Agreement for good reason
pursuant to this Section 5.4, Executive shall have the right to receive
Executive's compensation as provided hereunder through the effective date of
termination and shall also have the same rights and remedies against the Company
as Executive would have had if the Company had terminated Executive's employment
without cause pursuant to Section 5.1 (including the right to receive the
Severance Amount payable and the Severance Benefits to be provided under Section
5.2).

         5.5      Executive's Voluntary Termination. Executive may, at any time,
terminate this Agreement without good reason upon written notice delivered to
the Company at least 90 days prior to the effective date of termination. In the
event of such voluntary termination of this Agreement by Executive: (i)
Executive shall have the right to receive Executive's compensation as provided
hereunder through the effective date of termination; and (ii) the Company on the
one hand, and Executive, on the other hand, shall not have any further right or
remedy against one another except as provided in Sections 6, 7 and 8 hereof
which shall remain in full force and effect.

         5.6      Change of Control. Executive may terminate this Agreement,
upon at least 30 days' prior written notice to the Company at any time within
one year after a "change in control" (as hereinafter defined) of the Company. In
the event Executive terminates this Agreement within one year after a change in
control pursuant to this Section 5.6, (i) Executive shall continue to render
services pursuant hereto and shall continue to receive compensation, as provided
hereunder, through the termination date, (ii) the Company shall pay Executive no
later than the

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date of such termination, as a single severance payment, an amount equal to the
Severance Amount and (iii) following such termination, the Company shall provide
the Severance Benefits as required by Section 5.2(b). For purposes of this
Agreement, a "change in control" shall mean the occurrence of any of the
following events:

         (a)      an acquisition of any voting securities of the Company (the
"Voting Securities") by any "person" (as the term "person" is used for purposes
of Section 13(d) or Section 14(d) of the Securities Exchange Act of 1934, as
amended (the "1934 Act")) immediately after which such person has "beneficial
ownership" (within the meaning of Rule 13d-3 promulgated under the 1934 Act) of
50% or more of the combined voting power of the Company's then outstanding
Voting Securities; or

         (b)      approval by the stockholders of the Company of:

                  (i) a merger, consolidation, share exchange or reorganization
of the Company, unless the stockholders of the Company, immediately before such
merger, consolidation, share exchange or reorganization, own, directly or
indirectly immediately following such merger, consolidation, share exchange or
reorganization, at least 60% of the combined voting power of the outstanding
voting securities of the corporation that is the successor in such merger,
consolidation, share exchange or reorganization (the "Surviving Company") in
substantially the same proportion as their ownership of the Voting Securities
immediately before such merger, consolidation, share exchange or reorganization;
or

                  (ii) a complete liquidation or dissolution of the Company; or

                  (iii) an agreement for the sale or other disposition of all or
substantially all of the assets of the Company.

6.       NON-SOLICITATION

         During the period following the date Executive's employment hereunder
is terminated where the Executive continues to receive Compensation, Severance,
Benefits or Vesting under this Agreement, Executive shall not solicit or induce
any of the Company's employees, agents or independent contractors to end their
relationship with the Company, or recruit, hire or otherwise induce any such
person to perform services for Executive.

7.       NON-COMPETITION AfTER TERMINATION

         Executive agrees to be bound by the terms of the Confidential
Information and Non-Competition agreement attached hereto as Exhibit A and
incorporated herein by reference.

8.       INDEMNIFICATION

         To the fullest extent permitted under applicable law, the Company shall
indemnify, defend and hold Executive harmless from and against any and all
causes of action, claims, demands, liabilities, damages, costs and expenses of
any nature whatsoever (collectively, "Damages") directly or indirectly arising
out of or relating to Executive discharging Executive's duties hereunder on
behalf of the Company, so long as Executive acted in good faith within the

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course and scope of Executive's duties with respect to the matter giving rise to
the claim or Damages for which Executive seeks indemnification.

9.       GENERAL PROVISIONS

         9.1      Assignment; Binding Effect. Neither the Company nor Executive
may assign, delegate or otherwise transfer this Agreement or any of their
respective rights or obligations hereunder without the prior written consent of
the other party. Any attempted prohibited assignment or delegation shall be
void. This Agreement shall be binding upon and inure to the benefit of any
permitted successors or assigns of the parties and the heirs, executors,
administrators and/or personal representatives of Executive.

         9.2      Notices. All notices, requests, demands and other
communications that are required or may be given under this Agreement shall be
in writing and shall be deemed to have been duly given where received if
personally delivered; when transmitted if transmitted by telecopy, electronic or
digital transmission method with electronic confirmation of receipt; the day
after it is sent, if sent for next-day delivery to a domestic address by
recognized overnight delivery service (e.g., FEDEX); and upon receipt, if sent
by certified or registered mail, return receipt requested. In each case notice
shall be sent to:

         If to the Company:       Aderis Pharmaceuticals, Inc.
                                  85 Main Street
                                  Hopkinton, MA 01748
                                  Attention: Chief Executive Officer
                                  Facsimile: 508-497-9553

         If to Executive:         Kenneth L. Rice Jr.
                                  119 Brook Street
                                  Wellesley, MA 02482

Any party may change its address for the purpose of this Section 9.2 by giving
the other party written notice of its new address in the manner set forth above.

         9.3      Entire Agreement. This Agreement constitutes the entire
agreement of the parties, and supersedes all prior agreements, employment
letters, understandings and negotiations, whether written or oral, between the
Company and Executive with respect to the employment of Executive by the
Company.

         9.4      Amendments; Waivers. This Agreement may be amended or
modified, and any of the terms and covenants may be waived, only by a written
instrument executed by the parties hereto, or, in the case of a waiver, by the
party waiving compliance. Any waiver by any party in any one or more instances
of any term or covenant contained in this Agreement shall neither be deemed to
be nor construed as a further or continuing waiver of any such term or covenant
of this Agreement.

         9.5      Provision; Severable. In case any one or more provisions of
this Agreement shall be invalid, illegal or unenforceable in any respect, the
validity, legality and enforceability of the

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remaining provisions contained herein shall not, in any way, be affected or
impaired thereby. If any provision hereof is determined by any court of
competent jurisdiction to be invalid or unenforceable by reason of such
provision extending the covenants and agreements contained herein for too great
a period of time or over too great a geographical area, or being too extensive
in any other respect, such provision shall be interpreted to extend only over
the maximum period of time and geographical area, and to the maximum extent in
all other respects, as to which it is valid and enforceable, all as determined
by such court in such action.

         9.6      Attorneys' Fees. If any legal action, arbitration or other
proceeding, is brought for the enforcement of this Agreement, or because of an
alleged dispute, breach or default in connection with any of the provisions of
this Agreement, the prevailing party shall be entitled to recover reasonable
attorneys' fees and other costs incurred in that action or proceeding, including
any appeal of such action or proceeding, in addition to any other relief to
which that party may be entitled.

         9.7      Governing Law. This Agreement shall be construed, performed
and enforced in accordance with, and governed by the laws of the State of
Delaware without giving effect to the principles of conflict of laws thereof.

         9.8      Counterparts. This Agreement may be executed in one or more
counterparts, each of which shall be deemed an original, but all of which shall
constitute the same instrument.

         IN WITNESS WHEREOF, the parties hereto have executed this Agreement
effective as of the date first written above.

THE COMPANY

ADERIS PHARMACEUTICALS, INC.
a Delaware corporation

By:  /s/ PETER G. SAVAS
     -----------------------------------------
     Peter G. Savas,
     Chief Executive Officer and President

EXECUTIVE

/s/ KENNETH L. RICE, JR.
----------------------------------------------
Kenneth L. Rice, Jr.

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                                    EXHIBIT A

              CONFIDENTIAL INFORMATION AND NONCOMPETITION AGREEMENT

To: Aderis Pharmaceuticals, Inc.         Date:

         The undersigned, in consideration of and as a condition of my
employment or continued employment by you and/or by companies that you own,
control, or are affiliated with or their successors in business (collectively,
the "Company"), hereby agrees as follows:

         1. Confidentiality. I agree to keep confidential, except as the Company
may otherwise consent in writing, and except for the Company's benefit, not to
disclose or make any use of at any time either during or subsequent to my
employment, any Inventions (as hereinafter defined), trade secrets, confidential
information, knowledge, data or other information of the Company relating to
products, franchises, processes, know-how, techniques, methods, designs,
formulas, test data, customer lists, business plans, marketing plans and
strategies, pricing strategies, or other subject matter pertaining to any
business of the Company or any of its affiliates, which I may produce, obtain,
or otherwise acquire during the course of my employment, except as herein
provided. I further agree not to deliver, reproduce or in any way allow any such
trade secrets, confidential information, knowledge, data or other information,
or any documentation relating thereto, to be delivered to or used by any third
parties without specific direction or consent of the Chairman of the Board or
the Chief Executive Officer of the Company. The provisions of this Section 1
shall not apply to such knowledge, data or other information that is generally
known to the public.

         2. Conflicting Employment; Return of Confidential Material. I agree
that during my employment with the Company I will not engage in any other
employment, occupation, consulting or other activity relating to the business in
which the Company is now or may hereafter become engaged, or which would
otherwise conflict with my obligations to the Company. In the event my
employment with the Company terminates for any reason whatsoever, I agree to
promptly surrender and deliver to the Company all trade secrets, confidential
information, processes and records, including, but not limited to, designs,
formulae, test data, customer lists, business plans and strategies, Inventions
or other written memoranda, materials, equipment, drawings, documents and data
that I may obtain or produce during the course of my employment, and I will not
take with me any description containing or pertaining to any confidential
information, knowledge or data of the Company that I may produce or obtain
during the course of my employment.

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         3.       Assignment of Inventions.

                  3.1 I hereby acknowledge and agree that the Company is the
owner of all Inventions. In order to protect the Company's rights to such
Inventions, by executing this Agreement I hereby irrevocably assign to the
Company all my right, title and interest in and to all Inventions to the
Company.

                  3.2 For purposes of this Agreement, "Inventions" shall mean
all discoveries, processes, designs, technologies, methods, techniques, devices,
or improvements in any of the foregoing or other ideas, whether or not
patentable or copyrightable and whether or not reduced to practice, made or
conceived by me (whether solely or jointly with others) during the period of my
employment with the Company that relate to the actual or demonstrably
anticipated business, work, or research and development of the Company, or
result from or are suggested by any task assigned to me or any work performed by
me for or on behalf of the Company.

                  3.3 Any discovery, process, design, method, technique,
technology, device, or improvement in any of the foregoing or other ideas,
whether or not patentable or copyrightable and whether or not reduced to
practice, made or conceived by me (whether solely or jointly with others) that I
develop entirely on my own time not using any of the Company's equipment,
supplies, facilities, or trade secret information ("Personal Invention") is
excluded from this Agreement provided such Personal Invention (a) does not
relate to the actual or demonstrably anticipated business, research and
development of the Company, and (b) does not result, directly or indirectly,
from any work performed by me for the Company.

         4.       Disclosure of Inventions. I agree that in connection with any
Invention, I will promptly disclose such Invention to the Board of Directors of
the Company in order to permit the Company to enforce its property rights to
such Invention in accordance with this Agreement. My disclosure shall be
received in confidence by the Company. If the Company in good faith decides not
to use an Invention, it will advise me of same and the rights to such Invention
will revert to me within a reasonable period of time.

         5.       Patents and Copyrights; Execution of Documents.

                  5.1 Upon request, I agree to assist the Company or its nominee
(at its expense) during and at any time subsequent to my employment in every
reasonable way to obtain for its own benefit patents and copyrights for
Inventions in any and all countries. Such patents and copyrights shall be and
remain the sole and exclusive property of the Company or its nominee. I agree to
perform such lawful acts as the Company deems to be necessary to allow it to
exercise all right, title and interest in and to such patents and copyrights.

                  5.2 In connection with this Agreement, I agree to execute,
acknowledge and deliver to the Company or its nominee upon request and at its
expense all documents, including assignments of title, patent or copyright
applications, assignments of such applications, assignments of patents or
copyrights upon issuance, as the Company may determine necessary or desirable to
protect the Company's or its nominee's interest in Inventions, and/or to use in

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obtaining patents or copyrights in any and all countries and to vest title
thereto in the Company or its nominee to any of the foregoing.

         6.       Maintenance of Records. I agree to keep and maintain adequate
and current written records of all Inventions made by me (in the form of notes,
sketches, drawings, flowcharts, printouts, diskettes and other records as may be
specified by the Company), which records shall be available to and remain the
sole property of the Company at all times.

         7.       Prior Inventions. It is understood that all Personal
Inventions, if any, whether patented or unpatented, which I made prior to my
employment by the Company, are excluded from this Agreement. To preclude any
possible uncertainty, I have set forth on Schedule A attached hereto a complete
list of all of my prior Personal Inventions, including numbers of all patents
and patent applications and a brief description of all unpatented Personal
Inventions that are not the property of a previous employer. I represent and
covenant that the list is complete and that, if no items are on the list, I have
no such prior Personal Inventions. I agree to notify the Company in writing
before I make any disclosure or perform any work on behalf of the Company that
appears to threaten or conflict with proprietary rights I claim in any Personal
Invention. In the event of my failure to give such notice, I agree that I will
make no claim against the Company with respect to any such Personal Invention.

         8.       Other Obligations. I acknowledge that the Company from time to
time may have agreements with other persons, companies, entities, Governments or
agencies thereof, that impose obligations or restrictions on the Company
regarding Inventions made during the course of work thereunder or regarding the
confidential nature of such work. I agree to be bound by all such obligations
and restrictions and to take all actions necessary to discharge the Company's
obligations.

         9.       Trade Secrets of Others. I represent that my performance of
all the terms of this Agreement and as an employee of the Company does not and
will not breach any agreement to keep confidential proprietary information,
knowledge, or data acquired by me in confidence or in trust prior to my
employment with the Company, and I will not disclose to the Company, or induce
the Company to use, any confidential or proprietary information or material
belonging to any previous employer or others. I agree not to enter into any
agreement either written or oral in conflict herewith.

         10.      Post-Employment Activities.

                  10.1 For a period of one (1) year after the termination, for
any reason, of my employment with the Company, absent the Company's prior
written approval, I will not directly or indirectly engage in activities similar
or reasonably related to those in which I shall have engaged for the Company
during the two years immediately preceding termination, nor render services
similar or reasonably related to those which I shall have rendered during such
time to, any person or entity whether existing or hereafter established that
directly competes with (or proposes or plans to directly compete with) the
Company, or in other areas where the Company carries on a substantial amount of
business ("Direct Competitor"). In addition, I shall not entice,

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induce or encourage any of the Company's other employees to engage in any
activity that, were it done by me, would violate any provision of this
Agreement.

                  10.2 No provision of this Agreement shall be construed to
preclude me from performing the same services that the Company retains me to
perform for any person or entity that is not a Direct Competitor of the Company
upon the termination of my employment (or any post-employment consultation) so
long as I do not thereby violate any term of this Agreement.

         11.      Remedies. My obligations under this Agreement shall survive
the termination of my employment with the Company. I acknowledge that a remedy
at law for any breach or threatened breach by me of the provisions of this
Agreement would be inadequate and I therefore agree that the Company shall be
entitled to injunctive relief in case of any such breach or threatened breach.

         12.      Modification. I agree that any subsequent change or changes in
my employment duties, salary or compensation or, if applicable, in any
Employment Agreement between the Company and me, shall not affect the validity
or scope of this Agreement.

         13.      Successors and Assigns. This Agreement shall be binding upon
my heirs, executors, administrators or other legal representatives and is for
the benefit of the Company, its successors and assigns.

         14.      Interpretation. IT IS THE INTENT OF THE PARTIES THAT in case
any one or more of the provisions contained in this Agreement shall, for any
reason, be held to be invalid, illegal or unenforceable in any respect, such
invalidity, illegality or unenforceability shall not affect the other provisions
of this Agreement, and this Agreement shall be construed as if such invalid,
illegal, or unenforceable provision had never been contained herein. MOREOVER,
IT IS THE INTENT OF THE PARTIES THAT if any provision of this Agreement is or
becomes or is deemed invalid, illegal or unenforceable or in case any one or
more of the provisions contained in this Agreement shall for any reason be held
to be excessively broad as to duration, geographical scope, activity or subject,
such provision shall be construed by amending, limiting and/or reducing it to
conform to applicable laws so as to be valid and enforceable or, if it cannot be
so amended without materially altering the intention of the parties, it shall be
stricken and the remainder of this Agreement shall remain in full force and
effect.

         15.      Waivers. No waiver of any right under this Agreement shall be
deemed effective unless contained in a writing signed by the party charged with
such waiver, and no waiver of any right arising from any breach or failure to
perform shall be deemed to be a waiver of any future such right or of any other
right arising under this Agreement. If either party should waive any breach of
any provision of this Agreement, he or it shall not thereby be deemed to have
waived any preceding or succeeding breach of the same or any other provision of
this Agreement.

         16.      Complete Agreement, Amendments. The foregoing is the entire
agreement of the parties with respect to the subject matter hereof, superseding
any previous oral or written communications, representations, understandings, or
agreements with the Company or any officer or representative thereof. Any
amendment to this Agreement or waiver by the Company

                                       12

<PAGE>

of any right hereunder shall be effective only if evidenced by a written
instrument executed by the parties hereto, upon authorization of the Company's
Board of Directors.

         17.      Headings. The headings of the Sections contained in this
Agreement are inserted for convenience and reference only and in no way define,
limit, extend or describe the scope of this Agreement, or the intent of any
provision hereof, and shall not be deemed to constitute a part hereof nor to
affect the meaning of this Agreement in any way.

         18.      Governing Law. This Agreement shall be governed by and
construed in accordance with the internal laws of the Commonwealth of
Massachusetts, excluding its conflict of law principles.

         19.      Notices. All notices, requests, demands and communications
which are or may be required to be given hereunder shall be deemed effectively
given if and when sent by registered or certified mail, return receipt
requested, postage prepaid, to the following addresses:

                  If to the Company:

                  If to Employee:

         21.      Conflicts. In the event of any conflict between the provisions
of this agreement and the provisions of the Employment Agreement, the provisions
of the Employment Agreement will govern.

                                                Very truly yours,

Agreed:
Aderis Pharmaceuticals, Inc.

By:
   ----------------------------------------
     Peter G. Savas
     Chief Executive Officer and President

                                       13<PAGE>

                                                                   Exhibit 10.12

                              EMPLOYMENT AGREEMENT

         THIS EMPLOYMENT AGREEMENT ("Agreement") is made and entered into as of
January 2, 2002 (the "Effective Date"), by and between ADERIS PHARMACEUTICALS,
INC., a Delaware corporation (the "Company"), and William S. Wheeler, M.D.
("Executive").

AGREEMENT

1.       EMPLOYMENT

         The Company hereby employs Executive and Executive hereby accepts
employment upon the terms and conditions set forth below.

2.       TERM AND RENEWAL

         2.1      Term. The term of this Agreement shall commence on the
Effective Date, and shall continue for two (2) years from the Effective Date
(the "Original Employment Term"), on the terms and conditions set forth below,
unless sooner terminated as provided in Section 5.

         2.2      Extension. Following the expiration of the Original Employment
Term and provided that this Agreement has not been terminated pursuant to
Section 5, and every year thereafter, the Agreement shall be automatically
renewed for an additional 12 month period (the "Extension Period"), effective on
each anniversary date of the Effective Date, unless either party notifies the
other party in writing not less than 30 days prior to the expiration of the
Original Employment Term or any subsequent 12 month period.

3.       COMPENSATION

         3.1      Base Compensation. For the services to be rendered by
Executive under this Agreement, Executive shall be entitled to receive an
initial annual base compensation ("Base Compensation") of $260,000, payable in
substantially equal bi-weekly installments. Thereafter, the Base Compensation
shall be reviewed and adjusted annually as recommended by the Compensation
Committee (the "Compensation Committee") and approved by the Board of Directors
(the "Board") of the Company, or if there is no Compensation Committee, then by
the Board; provided, however, in no event may the Base Compensation be adjusted
below the initial annual Base Compensation set forth in this Section 3.1.

         3.2      Bonus Compensation. The Compensation Committee shall review
Executive's performance at least annually during each year of the Original
Employment Term and during any periods of automatic extension of this Agreement
pursuant to Section 2.2. The Compensation Committee shall recommend and the
Board shall approve and authorize the Company to award Executive a cash bonus
which shall reasonably be determined as fairly compensating and rewarding
Executive for services rendered to the Company and/or as an incentive for
continued service to the Company. The amount of such cash bonus shall be
determined in the sole and absolute discretion of the Board based upon the
recommendation of the Compensation Committee, shall be dependent on, among other
things, the achievement of certain performance

<PAGE>

levels by the Company, including, growth in funds from operations, and
Executive's performance and contribution to increasing the funds from
operations.

         3.3      Benefits.

                  (a)      Medical Insurance. The Company shall provide to
Executive and Executive's spouse and children, at its sole cost, such health,
dental and optical insurance as the Company may from time to time make available
to its other executive employees.

                  (b)      Life and Disability Insurance. The Company shall
provide Executive such disability and life insurance as the Company in its sole
discretion may from time to time make available to its other executive
employees.

                  (c)      Pension Plans, Etc. Executive shall be entitled to
participate in all pension, 401(k) and other employee plans and benefits
established by the Company on at least the same terms as the Company's other
executive employees.

         3.4      Vacation. Executive shall be entitled to four (4) vacation
weeks (20 business days) in each calendar year, subject to and on a basis
consistent with Company policy. In addition, Executive shall be entitled to all
Company holidays.

4.       POSITION AND DUTIES

         4.1      Position. Executive shall serve as Vice President, Chief
Medical Officer. The Company agrees that the duties that may be assigned
Executive shall be the usual and customary duties of the offices of Vice
President, Chief Medical Officer. Executive shall have such executive power and
authority as shall reasonably be required to enable Executive to discharge the
duties of such offices. At the Company's request, Executive may, at Executive's
discretion, serve the Company and its respective subsidiaries in other offices
and capacities in addition to the foregoing, but shall not be required to do so.
In the event the Company and Executive mutually agree that Executive shall
terminate Executive's service in any one or more of the aforementioned
capacities, or Executive's service in one or more of the aforementioned
capacities is terminated, Executive's compensation, as specified in this
Agreement, shall not be diminished or reduced in any manner.

         4.2      Devotion of Time and Effort. Executive shall use Executive's
good faith best efforts and judgment in performing Executive's duties as
required hereunder and to act in the best interests of the Company. Executive
shall devote substantially all of his business time and attention to the
performance of services of the Company in his capacity as an officer thereof and
as may reasonably be requested by the Board.

         4.3      Other Activities. Executive may engage in other activities for
Executive's own account while employed hereunder, including, charitable,
community and other business activities, provided that such other activities do
not materially interfere with the performance of Executive's duties hereunder.

         4.4      Business Expenses. The Company shall promptly, but in no event
later than ten days after submission of a claim of expenditure, reimburse
Executive for all reasonable business

                                        2

<PAGE>

expenses including, business seminar fees, professional association dues and
reasonable entertainment expenses incurred by Executive in connection with the
business of the Company, upon presentation to the Company of written receipts
for such expenses. Such reimbursement shall also include, but not be limited to,
reimbursement for all reasonable travel expenses, including all airfare, hotel
and rental car expenses incurred by Executive in travelling in connection with
the business of the Company.

         4.5      Company's Obligations. The Company shall provide Executive
with any and all necessary or appropriate current financial information and
access to current information and records regarding all material transactions
involving the Company, including but not limited to acquisition of assets,
personnel contracts, dispositions of assets, service agreements and registration
statements or other state or federal filings or disclosures, reasonably
necessary for Executive to carry out Executive's duties and responsibilities
hereunder. In addition, the Company agrees to provide Executive, as a condition
to Executive's services hereunder, such staff, equipment and office space as is
reasonably necessary for Executive to perform Executive's duties hereunder.

5.       TERMINATION

         5.1      By Company Without Cause. The Company may terminate this
Agreement without "cause" (as hereinafter defined) at any time following the
Effective Date, provided that the Company first deliver to Executive the
Company's written election to terminate this Agreement at least 90 days prior to
the effective date of termination.

         5.2      Severance Payment.

                  (a)      Amount. In the event the Company terminates
Executive's services hereunder without cause pursuant to Section 5.1 or by
Executive pursuant to Section 5.4 or 5.6, Executive shall continue to render
services to the Company pursuant to this Agreement until the date of termination
and shall continue to receive compensation, as provided hereunder, through the
termination date. In addition to other compensation payable to Executive for
services rendered through the termination date, the Company shall pay Executive
no later than the date of such termination, as a single severance payment, an
amount equal to (i) Executive's highest monthly Base Compensation paid hereunder
during the preceding 12 month period, multiplied by the greater of the number of
months remaining in the employment term (as determined under Section 2 above)
measured from the termination date or 12, plus (ii) one times the average annual
bonus received by the Executive during the preceding twenty-four month period
(the "Severance Amount").

                  (b)      Benefits. In the event Executive's employment
hereunder is terminated by the Company without cause pursuant to Section 5.1, by
the Company with cause on account of Executive's Disability (as defined in
Section 5.3(d) hereof), or by Executive pursuant to Section 5.4 or 5.6, then in
addition to paying Executive the Severance Amount, the Company shall continue to
provide to Executive and Executive's spouse and children, as applicable, all of
the benefits described in Section 3.3 for a period equal to the greater of (i)
the remaining term of this Agreement or (ii) one year commencing on the date of
such termination (the "Severance Benefits").

                                        3

<PAGE>

                  (c)      Acceleration of Vesting.

                           (i)      In the event Executive's employment
hereunder is terminated by the Company without cause pursuant to Section 5.1, or
by Executive pursuant to Section 5.4 or 5.6, then in addition to paying
Executive the Severance Amount and the Severance Benefits, the vesting of (A)
the unvested portion of any stock option to purchase Company common stock
granted to Executive ("Stock Options") and (B) any shares of Company common
stock granted to Executive which is subject to forfeiture ("Restricted Stock"),
shall continue to vest for a period of (1) one year and, with respect to the
vested portion of any Restricted Stock, shall cease to be subject to forfeiture
and, with respect to the vested portion of any Stock Options, shall be
exercisable.

                           (ii)     In the event Executive's employment
hereunder is terminated on account of Executive's death, the vesting of (A) the
unvested portion of any stock option to purchase Company common stock granted to
Executive ("Stock Options") and (B) any shares of Company common stock granted
to Executive which is subject to forfeiture ("Restricted Stock"), shall continue
to vest for a period of (1) one year and, with respect to the vested portion of
any Restricted Stock, shall cease to be subject to forfeiture and, with respect
to the vested portion of any Stock Options, shall be exercisable.

         5.3      By the Company For Cause. The Company may terminate Executive
for cause at any time, upon written notice to Executive. For purposes of this
Agreement, "cause" shall mean:

                  (a)      Executive's conviction for commission of a felony;

                  (b)      Executive's willful commission of any act of theft,
embezzlement or misappropriation against the Company;

                  (c)      Executive's willful and continued failure to
substantially perform Executive's duties hereunder (other than such failure
resulting from Executive's incapacity due to physical or mental illness), which
failure is not remedied within a reasonable time after written demand for
substantial performance is delivered by the Company which specifically
identifies the manner in which the Company believes that Executive has not
substantially performed Executive's duties; or

                  (d)      Executive's death or Disability (as hereinafter
defined).

         In the event Executive is terminated for cause pursuant to this Section
5.3, Executive shall have the right to receive Executive's compensation as
otherwise provided under this Agreement through the effective date of
termination. Executive shall have no further right to receive compensation or
other consideration from the Company or have any other remedy whatsoever against
the Company as a result of this Agreement or the termination of Executive
pursuant to this Section 5.3, except as set forth below with respect to a
termination due to Executive's Disability.

         In the event Executive is terminated by reason of Executive's
Disability (but not death), the Company shall immediately pay Executive a single
severance payment equal to the Severance Amount. Said payment shall be in
addition to any disability insurance payments to

                                        4

<PAGE>

which Executive is otherwise entitled and any other compensation earned by
Executive hereunder. For purposes of this Agreement, the term "Disability" shall
mean a physical or mental incapacity as a result of which Executive becomes
unable to continue the proper performance of Executive's duties hereunder for
six consecutive calendar months or for shorter periods aggregating 180 business
days in any 12 month period, but only to the extent that such definition does
not violate the Americans with Disabilities Act of 1990.

         5.4      By Executive For Good Reason. Executive may terminate this
Agreement for good reason upon at least 30 days' prior written notice to the
Company. For purposes of this Agreement, "good reason" shall mean:

                  (a)      the Company's material breach of any of its
respective obligations hereunder and either such breach is incurable or, if
curable, has not been cured within 30 business days following receipt by the
Company of written notice from Executive to the Company of such breach by the
Company;

                  (b)      any material decrease in Executive's authority or
responsibilities as Vice President, Chief Medical Officer of the Company without
Executive's prior written consent; or

                  (c)      any decrease in the Base Compensation including any
adjustments under Section 3.1 above or Benefits under Section 3.3 above payable
to Executive by the Company without Executive's prior consent; any decrease in
the Bonus Compensation under Section 3.2 above shall not constitute good reason;
or

         In the event that Executive terminates this Agreement for good reason
pursuant to this Section 5.4, Executive shall have the right to receive
Executive's compensation as provided hereunder through the effective date of
termination and shall also have the same rights and remedies against the Company
as Executive would have had if the Company had terminated Executive's employment
without cause pursuant to Section 5.1 (including the right to receive the
Severance Amount payable and the Severance Benefits to be provided under Section
5.2).

         5.5      Executive's Voluntary Termination. Executive may, at any time,
terminate this Agreement without good reason upon written notice delivered to
the Company at least 90 days prior to the effective date of termination. In the
event of such voluntary termination of this Agreement by Executive: (i)
Executive shall have the right to receive Executive's compensation as provided
hereunder through the effective date of termination; and (ii) the Company on the
one hand, and Executive, on the other hand, shall not have any further right or
remedy against one another except as provided in Sections 6, 7 and 8 hereof
which shall remain in full force and effect.

         5.6      Change of Control. Executive may terminate this Agreement,
upon at least 30 days' prior written notice to the Company at any time within
one year after a "change in control" (as hereinafter defined) of the Company. In
the event Executive terminates this Agreement within one year after a change in
control pursuant to this Section 5.6, (i) Executive shall continue to render
services pursuant hereto and shall continue to receive compensation, as provided
hereunder, through the termination date, (ii) the Company shall pay Executive no
later than the date of such termination, as a single severance payment, an
amount equal to the Severance

                                        5

<PAGE>

Amount and (iii) following such termination, the Company shall provide the
Severance Benefits as required by Section 5.2(b). For purposes of this
Agreement, a "change in control" shall mean the occurrence of any of the
following events:

                  (a)      an acquisition of any voting securities of the
Company (the "Voting Securities") by any "person" (as the term "person" is used
for purposes of Section 13(d) or Section 14(d) of the Securities Exchange Act of
1934, as amended (the "1934 Act")) immediately after which such person has
"beneficial ownership" (within the meaning of Rule 13d-3 promulgated under the
1934 Act) of 50% or more of the combined voting power of the Company's then
outstanding Voting Securities; or

                  (b)      approval by the stockholders of the Company of:

                           (i)      a merger, consolidation, share exchange or
reorganization of the Company, unless the stockholders of the Company,
immediately before such merger, consolidation, share exchange or reorganization,
own, directly or indirectly immediately following such merger, consolidation,
share exchange or reorganization, at least 60% of the combined voting power of
the outstanding voting securities of the corporation that is the successor in
such merger, consolidation, share exchange or reorganization (the "Surviving
Company") in substantially the same proportion as their ownership of the Voting
Securities immediately before such merger, consolidation, share exchange or
reorganization; or

                           (ii)     a complete liquidation or dissolution of the
Company; or

                           (iii)    an agreement for the sale or other
disposition of all or substantially all of the assets of the Company.

6.       NON-SOLICITATION

         During the period following the date Executive's employment hereunder
is terminated where the Executive continues to receive Compensation, Severance,
Benefits or Vesting under this Agreement, Executive shall not solicit or induce
any of the Company's employees, agents or independent contractors to end their
relationship with the Company, or recruit, hire or otherwise induce any such
person to perform services for Executive.

7.       NON-COMPETITION AfTER TERMINATION

         Executive agrees to be bound by the terms of the Confidential
Information and Non-Competition agreement attached hereto as Exhibit A and
incorporated herein by reference.

8.       INDEMNIFICATION

         To the fullest extent permitted under applicable law, the Company shall
indemnify, defend and hold Executive harmless from and against any and all
causes of action, claims, demands, liabilities, damages, costs and expenses of
any nature whatsoever (collectively, "Damages") directly or indirectly arising
out of or relating to Executive discharging Executive's duties hereunder on
behalf of the Company, so long as Executive acted in good faith within the

                                        6

<PAGE>

course and scope of Executive's duties with respect to the matter giving rise to
the claim or Damages for which Executive seeks indemnification.

9.       GENERAL PROVISIONS

         9.1      Assignment; Binding Effect. Neither the Company nor Executive
may assign, delegate or otherwise transfer this Agreement or any of their
respective rights or obligations hereunder without the prior written consent of
the other party. Any attempted prohibited assignment or delegation shall be
void. This Agreement shall be binding upon and inure to the benefit of any
permitted successors or assigns of the parties and the heirs, executors,
administrators and/or personal representatives of Executive.

         9.2      Notices. All notices, requests, demands and other
communications that are required or may be given under this Agreement shall be
in writing and shall be deemed to have been duly given where received if
personally delivered; when transmitted if transmitted by telecopy, electronic or
digital transmission method with electronic confirmation of receipt; the day
after it is sent, if sent for next-day delivery to a domestic address by
recognized overnight delivery service (e.g., FEDEX); and upon receipt, if sent
by certified or registered mail, return receipt requested. In each case notice
shall be sent to:

         If to the Company:            Aderis Pharmaceuticals, Inc.
                                       85 Main Street
                                       Hopkinton, MA 01748
                                       Attention: Chief Executive Officer
                                       Facsimile: 508-497-9553

         If to Executive:              William S. Wheeler
                                       205 Whitcomb Lane
                                       Cary, NC 27511

Any party may change its address for the purpose of this Section 9.2 by giving
the other party written notice of its new address in the manner set forth above.

         9.3      Entire Agreement. This Agreement constitutes the entire
agreement of the parties, and supersedes all prior agreements, employment
letters, understandings and negotiations, whether written or oral, between the
Company and Executive with respect to the employment of Executive by the
Company.

         9.4      Amendments; Waivers. This Agreement may be amended or
modified, and any of the terms and covenants may be waived, only by a written
instrument executed by the parties hereto, or, in the case of a waiver, by the
party waiving compliance. Any waiver by any party in any one or more instances
of any term or covenant contained in this Agreement shall neither be deemed to
be nor construed as a further or continuing waiver of any such term or covenant
of this Agreement.

                                        7

<PAGE>

         9.5      Provision; Severable. In case any one or more provisions of
this Agreement shall be invalid, illegal or unenforceable in any respect, the
validity, legality and enforceability of the remaining provisions contained
herein shall not, in any way, be affected or impaired thereby. If any provision
hereof is determined by any court of competent jurisdiction to be invalid or
unenforceable by reason of such provision extending the covenants and agreements
contained herein for too great a period of time or over too great a geographical
area, or being too extensive in any other respect, such provision shall be
interpreted to extend only over the maximum period of time and geographical
area, and to the maximum extent in all other respects, as to which it is valid
and enforceable, all as determined by such court in such action.

         9.6      Attorneys' Fees. If any legal action, arbitration or other
proceeding, is brought for the enforcement of this Agreement, or because of an
alleged dispute, breach or default in connection with any of the provisions of
this Agreement, the prevailing party shall be entitled to recover reasonable
attorneys' fees and other costs incurred in that action or proceeding, including
any appeal of such action or proceeding, in addition to any other relief to
which that party may be entitled.

         9.7      Governing Law. This Agreement shall be construed, performed
and enforced in accordance with, and governed by the laws of the State of
Delaware without giving effect to the principles of conflict of laws thereof.

         9.8      Counterparts. This Agreement may be executed in one or more
counterparts, each of which shall be deemed an original, but all of which shall
constitute the same instrument.

         IN WITNESS WHEREOF, the parties hereto have executed this Agreement
effective as of the date first written above.

THE COMPANY

ADERIS PHARMACEUTICALS, INC.
a Delaware corporation

By: /s/ Peter G. Savas
    -------------------------------------
    Peter G. Savas,
    Chief Executive Officer and President

EXECUTIVE

/s/ William S. Wheeler, M.D.
------------------------------------------
William S. Wheeler, M.D.

                                        8

<PAGE>

                                    EXHIBIT A

              CONFIDENTIAL INFORMATION AND NONCOMPETITION AGREEMENT

To: Aderis Pharmaceuticals, Inc.                 Date:

         The undersigned, in consideration of and as a condition of my
employment or continued employment by you and/or by companies that you own,
control, or are affiliated with or their successors in business (collectively,
the "Company"), hereby agrees as follows:

         1.       Confidentiality. I agree to keep confidential, except as the
Company may otherwise consent in writing, and except for the Company's benefit,
not to disclose or make any use of at any time either during or subsequent to my
employment, any Inventions (as hereinafter defined), trade secrets, confidential
information, knowledge, data or other information of the Company relating to
products, franchises, processes, know-how, techniques, methods, designs,
formulas, test data, customer lists, business plans, marketing plans and
strategies, pricing strategies, or other subject matter pertaining to any
business of the Company or any of its affiliates, which I may produce, obtain,
or otherwise acquire during the course of my employment, except as herein
provided. I further agree not to deliver, reproduce or in any way allow any such
trade secrets, confidential information, knowledge, data or other information,
or any documentation relating thereto, to be delivered to or used by any third
parties without specific direction or consent of the Chairman of the Board or
the Chief Executive Officer of the Company. The provisions of this Section 1
shall not apply to such knowledge, data or other information that is generally
known to the public.

         2.       Conflicting Employment; Return of Confidential Material. I
agree that during my employment with the Company I will not engage in any other
employment, occupation, consulting or other activity relating to the business in
which the Company is now or may hereafter become engaged, or which would
otherwise conflict with my obligations to the Company. In the event my
employment with the Company terminates for any reason whatsoever, I agree to
promptly surrender and deliver to the Company all trade secrets, confidential
information, processes and records, including, but not limited to, designs,
formulae, test data, customer lists, business plans and strategies, Inventions
or other written memoranda, materials, equipment, drawings, documents and data
that I may obtain or produce during the course of my employment, and I will not
take with me any description containing or pertaining to any confidential
information, knowledge or data of the Company that I may produce or obtain
during the course of my employment.

                                        9

<PAGE>

         3.       Assignment of Inventions.

                  3.1      I hereby acknowledge and agree that the Company is
the owner of all Inventions. In order to protect the Company's rights to such
Inventions, by executing this Agreement I hereby irrevocably assign to the
Company all my right, title and interest in and to all Inventions to the
Company.

                  3.2      For purposes of this Agreement, "Inventions" shall
mean all discoveries, processes, designs, technologies, methods, techniques,
devices, or improvements in any of the foregoing or other ideas, whether or not
patentable or copyrightable and whether or not reduced to practice, made or
conceived by me (whether solely or jointly with others) during the period of my
employment with the Company that relate to the actual or demonstrably
anticipated business, work, or research and development of the Company, or
result from or are suggested by any task assigned to me or any work performed by
me for or on behalf of the Company.

                  3.3      Any discovery, process, design, method, technique,
technology, device, or improvement in any of the foregoing or other ideas,
whether or not patentable or copyrightable and whether or not reduced to
practice, made or conceived by me (whether solely or jointly with others) that I
develop entirely on my own time not using any of the Company's equipment,
supplies, facilities, or trade secret information ("Personal Invention") is
excluded from this Agreement provided such Personal Invention (a) does not
relate to the actual or demonstrably anticipated business, research and
development of the Company, and (b) does not result, directly or indirectly,
from any work performed by me for the Company.

         4.       Disclosure of Inventions. I agree that in connection with any
Invention, I will promptly disclose such Invention to the Board of Directors of
the Company in order to permit the Company to enforce its property rights to
such Invention in accordance with this Agreement. My disclosure shall be
received in confidence by the Company. If the Company in good faith decides not
to use an Invention, it will advise me of same and the rights to such Invention
will revert to me within a reasonable period of time.

         5.       Patents and Copyrights; Execution of Documents.

                  5.1      Upon request, I agree to assist the Company or its
nominee (at its expense) during and at any time subsequent to my employment in
every reasonable way to obtain for its own benefit patents and copyrights for
Inventions in any and all countries. Such patents and copyrights shall be and
remain the sole and exclusive property of the Company or its nominee. I agree to
perform such lawful acts as the Company deems to be necessary to allow it to
exercise all right, title and interest in and to such patents and copyrights.

                  5.2      In connection with this Agreement, I agree to
execute, acknowledge and deliver to the Company or its nominee upon request and
at its expense all documents, including assignments of title, patent or
copyright applications, assignments of such applications, assignments of patents
or copyrights upon issuance, as the Company may determine necessary or desirable
to protect the Company's or its nominee's interest in Inventions, and/or to use
in

                                       10

<PAGE>

obtaining patents or copyrights in any and all countries and to vest title
thereto in the Company or its nominee to any of the foregoing.

         6.       Maintenance of Records. I agree to keep and maintain adequate
and current written records of all Inventions made by me (in the form of notes,
sketches, drawings, flowcharts, printouts, diskettes and other records as may be
specified by the Company), which records shall be available to and remain the
sole property of the Company at all times.

         7.       Prior Inventions. It is understood that all Personal
Inventions, if any, whether patented or unpatented, which I made prior to my
employment by the Company, are excluded from this Agreement. To preclude any
possible uncertainty, I have set forth on Schedule A attached hereto a complete
list of all of my prior Personal Inventions, including numbers of all patents
and patent applications and a brief description of all unpatented Personal
Inventions that are not the property of a previous employer. I represent and
covenant that the list is complete and that, if no items are on the list, I have
no such prior Personal Inventions. I agree to notify the Company in writing
before I make any disclosure or perform any work on behalf of the Company that
appears to threaten or conflict with proprietary rights I claim in any Personal
Invention. In the event of my failure to give such notice, I agree that I will
make no claim against the Company with respect to any such Personal Invention.

         8.       Other Obligations. I acknowledge that the Company from time to
time may have agreements with other persons, companies, entities, Governments or
agencies thereof, that impose obligations or restrictions on the Company
regarding Inventions made during the course of work thereunder or regarding the
confidential nature of such work. I agree to be bound by all such obligations
and restrictions and to take all actions necessary to discharge the Company's
obligations.

         9.       Trade Secrets of Others. I represent that my performance of
all the terms of this Agreement and as an employee of the Company does not and
will not breach any agreement to keep confidential proprietary information,
knowledge, or data acquired by me in confidence or in trust prior to my
employment with the Company, and I will not disclose to the Company, or induce
the Company to use, any confidential or proprietary information or material
belonging to any previous employer or others. I agree not to enter into any
agreement either written or oral in conflict herewith.

         10.      Post-Employment Activities.

                  10.1     For a period of one (1) year after the termination,
for any reason, of my employment with the Company, absent the Company's prior
written approval, I will not directly or indirectly engage in activities similar
or reasonably related to those in which I shall have engaged for the Company
during the two years immediately preceding termination, nor render services
similar or reasonably related to those which I shall have rendered during such
time to, any person or entity whether existing or hereafter established that
directly competes with (or proposes or plans to directly compete with) the
Company, or in other areas where the Company carries on a substantial amount of
business ("Direct Competitor"). In addition, I shall not entice,

                                       11

<PAGE>

induce or encourage any of the Company's other employees to engage in any
activity that, were it done by me, would violate any provision of this
Agreement.

                  10.2     No provision of this Agreement shall be construed to
preclude me from performing the same services that the Company retains me to
perform for any person or entity that is not a Direct Competitor of the Company
upon the termination of my employment (or any post-employment consultation) so
long as I do not thereby violate any term of this Agreement.

         11.      Remedies. My obligations under this Agreement shall survive
the termination of my employment with the Company. I acknowledge that a remedy
at law for any breach or threatened breach by me of the provisions of this
Agreement would be inadequate and I therefore agree that the Company shall be
entitled to injunctive relief in case of any such breach or threatened breach.

         12.      Modification. I agree that any subsequent change or changes in
my employment duties, salary or compensation or, if applicable, in any
Employment Agreement between the Company and me, shall not affect the validity
or scope of this Agreement.

         13.      Successors and Assigns. This Agreement shall be binding upon
my heirs, executors, administrators or other legal representatives and is for
the benefit of the Company, its successors and assigns.

         14.      Interpretation. IT IS THE INTENT OF THE PARTIES THAT in case
any one or more of the provisions contained in this Agreement shall, for any
reason, be held to be invalid, illegal or unenforceable in any respect, such
invalidity, illegality or unenforceability shall not affect the other provisions
of this Agreement, and this Agreement shall be construed as if such invalid,
illegal, or unenforceable provision had never been contained herein. MOREOVER,
IT IS THE INTENT OF THE PARTIES THAT if any provision of this Agreement is or
becomes or is deemed invalid, illegal or unenforceable or in case any one or
more of the provisions contained in this Agreement shall for any reason be held
to be excessively broad as to duration, geographical scope, activity or subject,
such provision shall be construed by amending, limiting and/or reducing it to
conform to applicable laws so as to be valid and enforceable or, if it cannot be
so amended without materially altering the intention of the parties, it shall be
stricken and the remainder of this Agreement shall remain in full force and
effect.

         15.      Waivers. No waiver of any right under this Agreement shall be
deemed effective unless contained in a writing signed by the party charged with
such waiver, and no waiver of any right arising from any breach or failure to
perform shall be deemed to be a waiver of any future such right or of any other
right arising under this Agreement. If either party should waive any breach of
any provision of this Agreement, he or it shall not thereby be deemed to have
waived any preceding or succeeding breach of the same or any other provision of
this Agreement.

         16.      Complete Agreement, Amendments. The foregoing is the entire
agreement of the parties with respect to the subject matter hereof, superseding
any previous oral or written communications, representations, understandings, or
agreements with the Company or any officer or representative thereof. Any
amendment to this Agreement or waiver by the Company

                                       12

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of any right hereunder shall be effective only if evidenced by a written
instrument executed by the parties hereto, upon authorization of the Company's
Board of Directors.

         17.      Headings. The headings of the Sections contained in this
Agreement are inserted for convenience and reference only and in no way define,
limit, extend or describe the scope of this Agreement, or the intent of any
provision hereof, and shall not be deemed to constitute a part hereof nor to
affect the meaning of this Agreement in any way.

         18.      Governing Law. This Agreement shall be governed by and
construed in accordance with the internal laws of the Commonwealth of
Massachusetts, excluding its conflict of law principles.

         19.      Notices. All notices, requests, demands and communications
which are or may be required to be given hereunder shall be deemed effectively
given if and when sent by registered or certified mail, return receipt
requested, postage prepaid, to the following addresses:

                  If to the Company:

                  If to Employee:

         21.      Conflicts. In the event of any conflict between the provisions
of this agreement and the provisions of the Employment Agreement, the provisions
of the Employment Agreement will govern.

                                                               Very truly yours,

Agreed:
Aderis Pharmaceuticals, Inc.

By:___________________________________________
         Peter G. Savas
         Chief Executive Officer and President

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