Document:

EXHIBIT 4.8

                      SECOND AMENDMENT TO RIGHTS AGREEMENT

     This Second Amendment to Rights Agreement, dated as of September 28, 2000
(this "Amendment"), to the Rights Agreement dated as of February 25, 1999, and
amended January 10, 2000 (the "Rights Agreement"), between Biosource
International, Inc., a Delaware corporation (the "Company") and U.S. Stock
Transfer Corporation, as Rights Agent (the "Rights Agent").

     The Company and the Rights Agent have heretofore executed and delivered the
Rights Agreement. Pursuant to Section 26 of the Rights Agreement, the Company
and the Rights Agent may from time to time supplement or amend the Rights
Agreement in accordance with the provisions of Section 26 thereof.

     In consideration of the foregoing premises and mutual agreements set forth
in the Rights Agreement and this Amendment, the parties hereto agree as follows:

     1. The definition of "Exempt Person" in Section 1 of the Rights Agreement
is hereby amended and restated to read in its entirety as follows:

        "Exempt Person" shall include (i) the Company, (ii) any Subsidiary (as
hereinafter defined) of the Company, (iii) any employee benefit plan of the
Company or any of its Subsidiaries, or any entity holding shares of Common Stock
which was organized, appointed or established by the Company or any Subsidiary
of the Company for or pursuant to the terms of any such plan and (iv) Genstar
Capital Partners II, L.P., Stargen II LLC, Jean-Pierre Conte, Robert Weltman,
Richard Hoskins and Richard Paterson, and their respective Affiliates and
associates (collectively the "Genstar Capital Group")."

     2. Section 3(a) of the Rights Agreement is further amended by adding a new
sentence as the final sentence thereto, which shall read in its entirety as
follows:

        "Notwithstanding anything in this Rights Agreement to the contrary, a
Distribution Date shall not be deemed to have occurred solely as a result of (i)
the approval, execution or delivery of that certain Securities Purchase
Agreement, dated as of January 10, 2000, by and between the Company and Genstar
Capital Partners II, L.P. and Stargen II LLC, or any of the agreements or
instruments required to be executed and delivered in connection with the
transactions contemplated therein (collectively, the "Genstar Capital
Agreements"), (ii) the approval, execution or delivery of that certain
Securities Purchase Agreement, dated September 15, 2000, to be effective as of
August 9, 2000, as amended, by and between the Company and the Genstar Capital
Group, or any of the agreements or instruments required to be executed and
delivered in connection with the transactions contemplated therein
(collectively, the "Second Genstar Capital Agreements"), or (iii) the
consummation of the transactions contemplated by the Genstar Capital Agreements,
the Second Genstar Capital Agreements, or the performance of the terms of the
Genstar Capital Agreements or the Second Genstar Capital Agreements."

     3. This Amendment shall be governed by and construed in accordance with the
laws of the State of Delaware.

                                     Page 1
<PAGE>

     4. This Amendment may be executed in any number of counterparts and each of
such counterparts shall for all purposes be deemed an original, and all such
counterparts shall together constitute but one and the same instrument.

     5. Except as expressly set forth herein, this Amendment shall not by
implication or otherwise alter, modify, amend or in any way affect any of the
terms, conditions, obligations, covenants or agreements contained in the Rights
Agreement, all of which are ratified and affirmed in all respects and shall
continue in full force and effect.

     IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be
duly executed as of the day and year first above written.

                                     BIOSOURCE INDUSTRIES, INC.

                                     By:  /S/ RUSSELL D. HAYS
                                        -----------------------------------
                                           Russell D. Hays
                                           President and Chief Executive Officer

                                     U.S. STOCK TRANSFER CORPORATION

                                     By:   /S/ ENRIQUE ARTAZA
                                        -----------------------------------
                                        Name:  Enrique Artaza
                                        Title: Sr. Vice President

                                     Page 2EXHIBIT 4.9

                                    WAIVER TO
                            INVESTOR RIGHTS AGREEMENT

     THIS WAIVER (this "WAIVER") is made as of September 18, 2000 with respect
to the Investor Rights Agreement (the "AGREEMENT") dated as of February 15, 2000
by and among BioSource International, Inc., a Delaware corporation (the
"COMPANY"), Genstar Capital Partners II, L.P., a Delaware limited partnership,
and Stargen II LLC, a Delaware limited liability company (together, the
"INVESTORS") (capitalized terms used herein and not defined herein shall have
the meanings given such terms in the Agreement).

                                    RECITALS

     WHEREAS, the Agreement provides the Investors with a right of first
negotiation for the purchase of Additional Securities pursuant to Section 11 of
the Agreement and a preemptive right to purchase Additional Securities pursuant
to Section 12 of the Agreement; and

     WHEREAS, the Investors wish to waive these provisions in connection with
the Company's issuance of up to an aggregate of 331,050 shares of its Common
Stock pursuant to certain purchase agreements dated September 15, 2000 and
September 18, 2000 (the "TRANSACTION").

                                    AGREEMENT

     NOW, THEREFORE, in consideration of the foregoing premises, the Investors
hereby agree as follows:

     1.  The Investors hereby waive their rights under Section 11 and Section 12
         of the Agreement, solely with respect to the Transaction.

     2.   Except as stated above, the terms of the Agreement shall remain in
          effect and unchanged by this Waiver.

     3.  This Waiver may be executed in any number of counterparts or by
         facsimile, each of which shall be deemed to be an original, but all of
         which together shall constitute one and the same instrument.

<PAGE>

IN WITNESS WHEREOF, the Investors, intending to be legally bound, have duly
executed this Waiver to become effective as of the date first above written.

                                           GENSTAR CAPITAL PARTNERS II, L.P.

                                           By: Genstar Capital LLC
                                               Its General Partner

                                           By: /S/ JEAN-PIERRE L. CONTE
                                              ---------------------------------
                                                 Jean-Pierre L. Conte
                                                 Managing Director

                                           STARGEN II LLC

                                           By: /S/ JEAN-PIERRE L. CONTE
                                              ---------------------------------
                                                 Jean-Pierre L. Conte
                                                 Managing Director

                                     Page 2<PAGE>

                                                                    EXHIBIT 10.4

                            SHARE REALLOCATION AND
                        ESCROW PARTICIPATION AGREEMENT

          This SHARE REALLOCATION AND ESCROW PARTICIPATION AGREEMENT (this
"Agreement") is entered into as of September 30, 2000, by and among E*TRADE
Group, Inc., a Delaware corporation ("E*TRADE"), and the shareholders of
E*OFFERING Corp., a California corporation ( the "Company") listed on Exhibit A
hereto (the "Shareholders"). Capitalized terms used and not otherwise defined in
this Agreement shall have the respective meanings assigned to such terms in the
Agreement and Plan of Merger, dated as of May 15, 2000, as amended pursuant to
the Amendment Agreement dated as of September 26, 2000 (as so amended, the
"Merger Agreement"), by and among Wit SoundView Group, Inc. (formerly Wit
Capital Group, Inc., the "Parent"), Wit SoundView Corporation ("Wit") and the
Company.

                                   RECITALS

          WHEREAS, pursuant to the Merger Agreement, an Escrow Fund consisting
of ten percent (10%) of the Parent Shares issued thereunder will be established
to compensate Indemnified Persons for certain Damages;

          WHEREAS, in order to facilitate the transactions contemplated by the
Merger Agreement, E*TRADE has agreed to certain amendments to its Strategic
Alliance Agreement dated May 15, 2000 (the "Alliance Agreement"), with the
Parent; and

          WHEREAS, in order to induce E*TRADE to enter into such amendments, the
Shareholders desire to cause certain of their Escrow Shares to be deposited into
the Escrow Fund in lieu of Parent Shares issuable to E*TRADE in the Merger which
would otherwise be deposited into the Escrow Fund under the current terms of the
Merger Agreement, and to adjust their beneficial interests in the Escrow Fund
accordingly. In addition, the parties hereto further desire to adjust the Final
Allocation Schedule in order to reallocate the Parent Shares to be received as
part of the Aggregate Consideration in the Merger.

          NOW, THEREFORE, in consideration of the mutual covenants contained
herein, and for E*TRADE's agreement to certain amendments to the Alliance
Agreement, the parties hereto agree as follows:

          1.   Escrow Allocation Schedule. Notwithstanding anything to the
               --------------------------
contrary in the Merger Agreement, the Final Allocation Schedule of Parent Shares
to be deposited into the Escrow Fund shall be adjusted at the Effective Time so
as to not include any Parent Shares beneficially owned by E*TRADE or affiliates
controlled, in whole or in part, by E*TRADE. The number of Parent Shares
beneficially owned by E*TRADE and such affiliates that would otherwise be
included on the Final Allocation Schedule and contributed into the Escrow Fund
as Escrow Shares pursuant to the terms of the Merger Agreement shall instead be
comprised, in the aggregate, of an equal number (not to exceed 800,000) of
Parent Shares (the "Participation Shares") beneficially owned by the
Shareholders listed on Exhibit A hereto. At the Effective Time, the
Participation Shares shall be allocated to, and contributed and deposited in
escrow on behalf of, each Shareholder on a pro rata basis in the proportion
which the number of Parent Shares issued to
<PAGE>

each such Shareholder bears to the total number of Parent Shares issued to all
of the Shareholders in the Merger, and by way of illustration such allocation
according to the Preliminary Allocation Schedule under the Merger Agreement is
set forth on the Allocation Schedule attached hereto as Exhibit A. For the
avoidance of confusion, the parties will inform the Exchange Agent and the
Escrow Agent of the substitution of the Participation Shares as Escrow Shares in
lieu of Parent Shares issuable to E*TRADE in the Merger, as well as the
beneficial ownership interests of the Shareholders in the Participation Shares,
promptly following the Effective Time of the Merger, based upon the final number
of Parent Shares issued to each Shareholder as set forth on the Final Allocation
Schedule. Following the deposit of the Participation Shares into the Escrow Fund
as provided hereunder, the Shareholders will continue to have all right, title
and interest in and to their Participation Shares, subject to the terms of the
Merger Agreement and the Escrow Agreement.

          2.   Reallocation Schedule. Notwithstanding anything to the contrary
               ---------------------
in the Merger Agreement, the Final Allocation Schedule shall be adjusted at the
Effective Time so as to provide that 1,200,000 Parent Shares that would
otherwise be allocated on the Final Allocation Schedule to the Shareholders
pursuant to the terms of the Merger Agreement, shall instead be allocated to
E*TRADE in accordance with the terms of this Agreement (the "Reallocation
Shares"). At the Effective Time, the Reallocation Shares shall be allocated from
and on behalf of each Shareholder on a pro rata basis in the proportion which
the number of Parent Shares issued to each such Shareholder bears to the total
number of Parent Shares issued to all of the Shareholders in the Merger, and
such allocation is set forth on the Allocation Schedule attached hereto as
Exhibit A. Notwithstanding anything herein to the contrary, the foregoing
reallocation of Parent Shares shall not affect or be taken into account in
determining the number of Escrow Shares deposited in the Escrow Fund for the
account of any particular Shareholder, it being understood that ten percent
(10%) of the total number of Parent Shares issuable to each Shareholder before
giving effect to the reallocation of Reallocation Shares (i.e. assuming solely
for such purposes no such reallocation) shall be so deposited into the Escrow
Fund for the account of such Shareholder. For the avoidance of confusion, the
parties will inform the Exchange Agent and the Escrow Agent of the
redistribution of the Reallocation Shares from the Shareholders to E*TRADE
promptly following the Effective Time of the Merger. Following the distribution
of the Reallocation Shares to E*TRADE as provided hereunder, E*TRADE will have
all right, title and interest in and to the Reallocation Shares.

          3.   Further Assurances. Each of the parties hereto shall enter into
               ------------------
such other instruments and documents, and take such further actions, as are
reasonably necessary to effect the purposes of this Agreement.

          4.   Acknowledgment. Each of the parties hereto acknowledges and
               --------------
agrees that each other party has given them the opportunity to seek, and has
recommended that such parties obtain, independent legal advice with respect to
the subject matter of this Agreement. Further, each of the parties hereto hereby
represent and warrant to each of the other parties that such party has sought
such independent legal advice or has knowingly waived such advice.

          5.   Assignment. No party may, without the prior express written
               ----------
consent of

                                       2
<PAGE>

each other party, assign this Agreement in whole or in part. This Agreement
shall be binding upon and inure to the benefit of the respective permitted
successors and assigns of the parties hereto, and may only be amended or
modified pursuant to a written instrument executed by each of the parties
hereto.

          6.   Governing Law; Jurisdiction. This Agreement shall be governed by
               ---------------------------
and construed in accordance with the laws of the State of Delaware (other than
the conflicts of law principles thereof). Each of the parties hereto irrevocably
consents to the exclusive jurisdiction of any court located within the State of
Delaware, in connection with any matter based upon or arising out of this
Agreement or the matters contemplated herein, agrees that process may be served
upon them in any manner authorized by the laws of the State of Delaware for such
persons and waives and covenants not to assert or plead any objection which they
might otherwise have to such jurisdiction and such process.

          7.   Counterparts. This Agreement may be executed in one or more
               ------------
counterparts, all of which shall be considered one and the same agreement and
shall become effective when one or more counterparts have been signed by each of
the parties and delivered to the other parties, it being understood that all
parties need not sign the same counterpart.

                           [SIGNATURE PAGE FOLLOWS]

                                       3
<PAGE>

          IN WITNESS WHEREOF, the parties hereto have caused this Agreement to
be duly executed on their behalf as of the date first written above.

                                        E*TRADE Group, Inc.

                                        By:      /s/ Theodore J. Theophilos
                                             ----------------------------------
                                        Name: Matthew Nimentz
                                        Title: Chief Legal Affairs Officer

                                        /s/ Walter W. Cruttenden
                                        ----------------------------------------
                                        Walter W. Cruttenden

                                        Cruttenden Partners LLC

                                        By:      /s/ Walter W. Cruttenden
                                             -----------------------------------
                                        Name:  Walter W. Cruttenden
                                        Title: Managing Member

                                        /s/ Frank Cutler
                                        ----------------------------------------
                                        Frank Cutler

                                        /s/ Christopher Cruttenden
                                        ----------------------------------------
                                        Christopher Cruttenden

                                        /s/ Sanford Robertson
                                        ----------------------------------------
                                        Sanford Robertson
<PAGE>

                                        GAP Coinvestment Partners II LP

                                        By:      /s/ Matthew Nimetz
                                             -----------------------------------
                                        Name:  Matthew Nimetz
                                        Title: A General Partner

                                        General Atlantic Partners 61 LP
                                        By: General Atlantic Partners LLC,
                                            its general partner

                                        By:      /s/ Matthew Nimetz
                                             -----------------------------------
                                        Name:  Matthew Nimetz
                                        Title: A Managing Member

                                        New Enterprise Associates 9 L.P.

                                        By:      /s/ Thomas C. McConnell
                                             -----------------------------------
                                        Name:  Thomas C. McConnell
                                        Title: General Partner

                                        NEA Ventures 2000 L.P.

                                        By:      /s/ Jacqueline Myers
                                             -----------------------------------
                                        Name:  Jacqueline Myers
                                        Title: Vice President
<PAGE>

                                        Battery Ventures V L.P.

                                        By:      /s/ Kenneth P. Lawler
                                             -----------------------------------
                                        Name:  Kenneth P. Lawler
                                        Title: Member Manager

                                        Crosspoint Venture Partners 2000

                                        By:      /s/ R.A. Hope
                                             -----------------------------------
                                        Name:  R.A. Hope
                                        Title: General Partner

                                        Softbank Technology Ventures V L.P.
                                        By: SBTV LLC

                                        By:      /s/ D. Rex Golding
                                             -----------------------------------
                                        Name: D. Rex Golding
                                        Title:

                                        Softbank Technology Advisors Fund V L.P.
                                        By: SBTV LLC

                                        By:      /s/ D. Rex Golding
                                             -----------------------------------
                                        Name: D. Rex Golding
                                        Title:
<PAGE>

                                        Softbank Technology Entrepreneurs Fund V
                                        L.P.
                                        By: SBTV LLC

                                        By:      /s/ D. Rex Golding
                                             -----------------------------------
                                        Name: D. Rex Golding
                                        Title:
<PAGE>

ACKNOWLEDGED:

E*OFFERING, Inc.

By:    /s/ Stephen R. King
   ------------------------------
Name:  Stephen R. King
Title: President

Wit Capital Group, Inc.

By:    /s/ Mark F. Loehr
   ------------------------------
Name:  Mark F. Loehr
Title: Co-President

Wit Soundview Corporation

By:    /s/ Mark F. Loehr
   ------------------------------
Name:  Mark F. Loehr
Title: Co-President

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