Document:

EX-4.8

 Exhibit 4.8 

FORM 51-102F3 

MATERIAL CHANGE REPORT 
  

	1.	 Name and Address of Company  

Neptune Wellness Solutions Inc. 

[formerly, Neptune Technologies & Bioressources Inc.] (“Neptune”) 

545, Promenade du Centropolis, Suite 100 

Laval, Québec H7T 0A3 
  

	2.	 Date of Material Change  

September 21, 2018 
  

	3.	 News Release  

The news release was filed in SEDAR and disseminated through the facilities of CNW on September 19, 2018. 

 

	4.	 Summary of Material Change  

The Issuer changed its name to “Neptune Wellness Solutions Inc.” effective September 21, 2018. 

 

	5.	 Full Description of Material Change  

See attached news release. 
  

	6.	 Reliance on subsection 7.1(2) of National Instrument 51-102
 

 Not applicable. 
  

	7.	 Omitted Information  

Not applicable. 
  

	8.	 Executive Officer  

For further information, please contact: Mario Paradis, Vice President and Chief Financial Officer of Neptune, at +1 (450) 687-2262 x236. 
  

	9.	 Date of Report  

September 28, 2018 

 PRESS RELEASE 

 

					
	

	  	 SOURCE: Neptune Technologies & Bioressources Inc.

 
	  	

 Neptune Confirms its Name Change to 

Neptune Wellness Solutions Inc. 
 Laval,
Québec, CANADA – September 19, 2018 – Neptune Technologies & Bioressources Inc. (“Neptune” or the “Company”) (NASDAQ – TSX : NEPT) announces that
its shareholders have approved at the Annual Meeting of Shareholders held on August 15, 2018, the change of the Company’s legal name to Neptune Wellness Solutions Inc / Neptune Solutions Bien-Être Inc., in order to better
reflect the Company’s products and business. The name change will be effective upon opening of the markets on September 21, 2018. The Company’s common shares will keep trading under the same ticker symbol “NEPT” on NASDAQ
and TSX. 
 About Neptune Technologies & Bioressources Inc. 

Neptune is a health and wellness products company, with more than 50 years of combined experience in extraction, purification and formulation of value-added
differentiated science-based products. Currently, the Company develops turnkey nutrition product solutions available in various unique delivery forms, offers specialty ingredients such as
MaxSimil®, a patented ingredient that enhances the absorption of lipid-based nutraceuticals, and a variety of other marine and seed oils. Leveraging its scientific, technological and
innovative expertise, Neptune is preparing to commence production of products in legal cannabis markets. 
 The Company’s head office is located in
Laval, Quebec. 
 Neither NASDAQ nor the Toronto Stock Exchange accepts responsibility for the adequacy or accuracy of this release. 

 

					
	Neptune Wellness Solutions	  	Investor Relations Contact	  	Investor Relations Contact
	Mario Paradis	  	(Canada)	  	(U.S.)
	VP & CFO, Neptune	  	Pierre Boucher	  	Jody Burfening
	1.450.687.2262, x236	  	MaisonBrison	  	LHA, IR
	m.paradis@neptunecorp.com	  	1.514.731.0000	  	1.212.838.3777
		  	pierre@maisonbrison.com	  	jburfening@lhai.comEX-4.9

 Exhibit 4.9 

MATERIAL CHANGE REPORT 

FORM 51-102F3 
  

	Item 1.	 Name and Address of Company 

Neptune Wellness Solutions Inc. (“Neptune”) 

545 Promenade du Centropolis 

Suite 100 
 Laval, Québec

 H7T 0A3 
  

	Item 2.	 Date of Material Change 

January 7, 2019. 
  

	Item 3.	 News Release 

A news release with respect to the material change referred to in this report was issued and filed on SEDAR on January 7, 2019. 

 

	Item 4.	 Summary of Material Change 

On January 7, 2019, Neptune announced that it received its license to process cannabis from Health Canada. 

 

	Item 5.	 Full Description of Material Change 

Refer to press release attached hereto as Schedule A. 
  

	Item 6.	 Reliance on subsection 7.1(2) of National Instrument 51-102

 Not applicable. 
  

	Item 7.	 Omitted Information 

Not applicable. 
  

	Item 8.	 Executive Officer 

For further information please contact: 

Mario Paradis 
 Vice-President and
Chief Financial Officer 
 p: (450) 687-2262 x236 

e: m.paradis@neptunecorp.com 
  

	Item 9.	 Date of Report 

January 11, 2019. 

 SCHEDULE A 

			
	

	  	 PRESS RELEASE
  

 SOURCE: Neptune Wellness Solutions Inc. 

Neptune Receives License to Process Cannabis from Health Canada 

Laval, Québec, CANADA – January 7, 2019 – Neptune Wellness Solutions Inc. (“Neptune” or the “Company”) (NASDAQ
– TSX: NEPT) is pleased to announce today that it has received its license to process cannabis from Health Canada. 
 “In 2017, we embarked upon a
new strategic vision to position the Company in growth markets such as the legal cannabis market and to become a global leader in cannabis extraction, purification and formulation of value-added differentiated products. Since then, we have executed
a carefully-planned roadmap to ready our significant manufacturing capacity for production, secure multi-year commercial contracts with great companies like Canopy Growth, and expand our strategic relationships, recently beginning a collaboration
agreement with Lonza, a global market leader for the production of unique value-added capsules. We realized all this while moving along the various steps of the licensing process. Today, with our Health Canada processing license in hand, we
officially enter the sizable cannabis market and are fully ready to commence commercializing our extraction capabilities. This tremendous achievement reflects the professionalism and experience of our team, led by Michel Timperio, who is fully
committed and excited to begin actual delivery on the promise of our vision. Furthermore, we are very proud to be one of the few Quebec-based companies that have received a license from Health Canada, and look forward to contributing to this
emerging industry in our home province,” said Jim Hamilton, President & CEO of Neptune. 
 The Health Canada license enables Neptune to handle
dried cannabis, to manufacture and purify cannabis extracts and cannabis oil, and to sell its services to other license holders. With production activities anticipated to commence shortly at Neptune’s 50,000 square foot good manufacturing
practice (GMP)-certified facility in Sherbrooke, Quebec, the Company expects be able to generate revenues from existing supply agreements and conclude additional agreements shortly. 

Neptune remains on track to complete its Phase II capacity investment by March 2019, which will increase its facility’s input capacity to 200,000 kg of
dried cannabis from a current capacity of 30,000 kg. This will position Neptune among Canada’s largest cannabis processors, with additional significant capacity expansion potential in the Sherbrooke facility of up to 6,000 metric tons to meet
global demand for medical cannabis products. The collaboration with Lonza for the production of unique value-added capsules, combined with significant manufacturing capabilities, will allow Neptune to expand its strategy from a service provider to
other licence holders to a provider of differentiated cannabis products to customers in Canada. The Company is now in the process of applying for additional authorization for sale of cannabis products from Health Canada to complement the processing
license, allowing for further distribution of finished form cannabis products directly to consumers and patients. 
 “This is a thrilling moment for
Neptune as our ambition to redeploy our core competencies to exciting consumer product categories by creating and delivering differentiated formulations for the burgeoning cannabis market becomes a reality. Neptune’s long-standing scientific
expertise in the formulation of natural health products supports our ability to deliver exceptional quality formulations for our business customers. The processing license granted by the agency puts us on a new growth trajectory, positioning Neptune
as a provider of extracted cannabis products in this large, growing global market segment,” concluded Mr. Hamilton. 

  
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 About Neptune Wellness Solutions Inc. 

Neptune Wellness Solutions specializes in the extraction, purification and formulation of health and wellness products. Bringing decades of experience in the
natural products sector to the legal cannabis industry, Neptune is licensed by Health Canada to process cannabis for the production of cannabis extracts and oils at its 50,000 square foot facility located in Sherbrooke, Quebec. Leveraging its
scientific and technological expertise, Neptune acts as a service provider to license holders as part of a multi-phase growth strategy focused on the development of value-added and differentiated products for the Canadian and global cannabis
markets. Neptune’s activities also include the formulation, development and commercialization of turnkey nutrition solutions and patented ingredients such as MaxSimil®, and of a variety
of marine and seed oils. Its head office is located in Laval, Quebec. 
 Forward Looking Statements 

Statements in this press release that are not statements of historical or current fact constitute “forward-looking statements” within the meaning
of the U.S. securities laws and Canadian securities laws. Such forward-looking statements involve known and unknown risks, uncertainties, and other unknown factors that could cause the actual results of Neptune to be materially different from
historical results or from any future results expressed or implied by such forward-looking statements. In addition to statements which explicitly describe such risks and uncertainties, readers are urged to consider statements labeled with the terms
“believes,” “belief,” “expects,” “intends,” “anticipates,” “will,” “should,” or “plans” to be uncertain and forward-looking. Readers are cautioned not to place undue
reliance on these forward-looking statements, which speak only as of the date of this press release. Forward-looking information in this press release includes, but is not limited to, information or statements about our ability to successfully
develop, produce, supply, promote or generate any revenue from the sale of any cannabis-based products in the legal cannabis market. 
 The
forward-looking statements contained in this press release are expressly qualified in their entirety by this cautionary statement and the “Cautionary Note Regarding Forward-Looking Information” section contained in Neptune’s latest
Annual Information Form (the “AIF”), which also forms part of Neptune’s latest annual report on Form 40-F, and which is available on SEDAR at www.sedar.com, on EDGAR at www.sec.gov/edgar.shtml
and on the investor section of Neptune’s website at www.neptunecorp.com. All forward-looking statements in this press release are made as of the date of this press release. Neptune does not undertake to update any such forward-looking
statements whether as a result of new information, future events or otherwise, except as required by law. The forward-looking statements contained herein are also subject generally to other risks and uncertainties that are described from time to
time in Neptune public securities filings with the Securities and Exchange Commission and the Canadian securities commissions. Additional information about these assumptions and risks and uncertainties is contained in the AIF under “Risk
Factors”. 
 Neither NASDAQ nor the Toronto Stock Exchange accepts responsibility for the adequacy or accuracy of this release. 

Information: 
  

					
	Neptune Wellness Solutions	 	Investor Relations Contact	 	Investor Relations Contact
	Mario Paradis VP & CFO	 	(Canada)	 	(U.S.)
	1.450.687.2262, x236	 	Pierre Boucher	 	Jody Burfening/Carolyn Capaccio LHA
	m.paradis@neptunecorp.com	 	MaisonBrison	 	1.212.838.3777 jburfening@lhai.com
		 	1.514.731.0000	 	ccapaccio@lhai.com
		 	pierre@maisonbrison.com	 	

  
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 Media Requests: 

Neptune Wellness Solutions 
 Caroline Lavoie 

1.514.781.4501 
 c.lavoie@neptunecorp.com 

  
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