Document:

EX-4.3

 Exhibit 4.3 

Exhibit E 
 VOTING
AGREEMENT 
 This is a Voting Agreement (this “Agreement”), dated as of September 8, 2015 between Apellis
Pharmaceuticals, Inc., a Delaware corporation (“Apellis”), and Potentia Pharmaceuticals, Inc., a Delaware corporation (“Potentia”). 

A. This Agreement is being executed and delivered under the terms of the Asset Purchase Agreement dated as of September 24, 2014 between
Apellis and Potentia (the “Asset Purchase Agreement”) pursuant to which Apellis or its Nominee will purchase substantially all of the assets and assume certain of the liabilities of Potentia, for which Apellis will pay consideration
consisting of 8,200,000 shares of Apellis common stock (such number of shares being subject to adjustment in the event of any stock dividend, stock split, combination or other similar recapitalization affecting Apellis common stock occurring after
the date of the Asset Purchase Agreement and prior to the Closing) (such shares and any other securities of the Company, by whatever name called, which carry voting rights, which are subsequently acquired by Potentia being referred to collectively
as the “Transaction Shares”). 
 C. The Asset Purchase Agreement provides that Potentia shall execute and deliver this
Agreement to Apellis at the Closing of the Transaction. 
 D. For purposes of this Agreement, capitalized terms used and not defined herein
shall have the respective meanings ascribed to them in the Asset Purchase Agreement. 
 NOW, THEREFORE, in consideration of the premises and
for other good and valuable consideration, the receipt, sufficiency and adequacy of which are hereby acknowledged, the parties hereto agree as follows: 

1. Representations. 
 Potentia represents
and warrants to Apellis that Potentia has full corporate power and authority to enter into, execute and deliver this Agreement and to perform fully Potentia’s obligations hereunder (including the proxy described in Section 2(b) below).
This Agreement has been duly and validly executed and delivered by Potentia and constitutes the legal, valid and binding obligation of Potentia, enforceable against Potentia in accordance with its terms. 

2. Agreement to Vote Shares; Irrevocable Proxy. 

(a) Potentia agrees that during the term of this Agreement: 

 (i) on any matter submitted for a vote of holders of common stock of Apellis, Potentia will vote
(or abstain from voting) the Transaction Shares in the same ratio(s) as the other holders of Apellis common stock vote their shares. For example, if the other holders of Apellis common stock vote 87% in favor of a resolution, 9% against, and 4%
abstain, then the Transaction Shares will be voted in the same ratios; 
 (ii) if holders of common stock of Apellis are requested to vote
their shares through the execution of an action by written consent in lieu of any meeting of stockholders of Apellis, Potentia will execute a written consent or consents, only with respect to that percentage of the Transaction Shares equal to the
percentage of the shares of Apellis common stock held by the other holders of Apellis common stock for which written consents are executed and delivered. 

(b) Potentia hereby constitutes and appoints Apellis and any designee of Apellis, and each of them individually, as its proxies and
attorneys-in-fact, with full power of substitution and resubstitution, to represent and vote (or act by written consent) during the term of this Agreement with respect to the Transaction Shares in the manner set forth in Section 2(a). This
proxy and power of attorney is given in consideration of the agreements and covenants of Apellis and Potentia in connection with the transactions contemplated by this Agreement and the Asset Purchase Agreement and, as such, is coupled with an
interest and shall be irrevocable unless and until this Agreement terminates. Potentia shall take such further action or execute such other instruments as may be necessary to effectuate the intent of this proxy. The proxy and power of attorney
granted hereunder shall terminate upon the termination of this Agreement. 
 3. No Voting Trusts or Other Arrangement. 

Except as provided in the Voting Agreement dated as of July 30, 2013 by and among Apellis and the Stockholders (as defined therein), as
amended from time to time (the “Existing Voting Agreement”) to which Potentia shall become a party on the date hereof, Potentia revokes any and all previous proxies with respect to the Transaction Shares and agrees that it will not,
and will not permit any entity under Potentia’s control to, deposit any of the Transaction Shares in a voting trust, grant any proxies with respect to the Transaction Shares or subject any of the Transaction Shares to any arrangement with
respect to the voting of the Transaction Shares other than agreements entered into with Apellis. 
 4. Transfer and Encumbrance; Legend. 

(a) Potentia agrees that during the term of this Agreement, Potentia will not, directly or indirectly, transfer, sell, offer, exchange, assign,
or otherwise dispose of (“Transfer”) any of the Transaction Shares or enter into any contract, option or other agreement with respect to, or consent to, a Transfer of any of the Transaction Shares or Potentia’s voting interest
therein, except as permitted by the Asset Purchase Agreement. 

  
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 Any attempted Transfer of the Transaction Shares or any interest therein in violation of this Section 4
shall be null and void. This Section 4 shall not prohibit a Transfer of the Transaction Shares to a successor to Potentia in connection with the reorganization of Potentia as a Delaware limited liability company as contemplated by the Asset
Purchase Agreement; provided that the successor agrees in a writing reasonably satisfactory in form and substance to Apellis to be bound by all of the terms of this Agreement. 

(b) All certificates representing Transaction Shares owned or hereafter acquired by Potentia or any transferee of Potentia bound by this
Agreement shall have affixed thereto a legend substantially in the following form: 
 “The shares of stock represented by this
certificate are subject to certain voting agreements as set forth in a Voting Agreement, as amended and/or restated from time to time, by and among the registered owner of this certificate and the Company, a copy of which is available for inspection
at the offices of the Secretary of the Company.” 
 5. Termination. 

This Agreement shall terminate upon the earliest to occur of (a) the date Potentia or any successor to whom Potentia has transferred the
Transaction Shares as permitted by this Agreement and who is bound by the terms of this Agreement ceases to own or control any Transaction Shares, (b) the Sale of the Buyer, or (c) an Initial Public Offering, as those terms are defined in
the Asset Purchase Agreement. 
 6. Specific Performance. 

Each Party acknowledges that it will be impossible to measure in money the damage to the other Party if a Party fails to comply with any of the
obligations imposed by this Agreement, that every such obligation is material and that, in the event of any such failure, the other party will not have an adequate remedy at law or damages. Accordingly, each Party agrees that, in addition to
remedies at law or damages, the other Party shall be entitled to an injunction to prevent breaches of this Agreement and to specific enforcement of this Agreement and its terms and provisions in any action instituted in any court of the United
States or any state thereof having jurisdiction over the Parties and the matter, and will not oppose such relief on the basis that the other Party has an adequate remedy at law. Each Party agrees that it will not seek, and agrees to waive any
requirement for, the securing or posting of a bond in connection with the other party’s seeking or obtaining such equitable relief. 
 7. Entire
Agreement. 

	

  
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 This Agreement, together with the Existing Voting Agreement, supersedes all prior agreements,
written or oral, between the Parties with respect to the subject matter hereof and contains the entire agreement between the parties with respect to the subject matter hereof. This Agreement may not be amended or supplemented, and no provisions
hereof may be modified or waived, except by an instrument in writing signed by both of the parties hereto. No waiver of any provisions hereof by either party shall be deemed a waiver of any other provisions hereof by such party, nor shall any such
waiver be deemed a continuing waiver of any provision hereof by such party. To the extent the the provisions of the Existing Voting Agreement conflict with the provisions of this Agreement, the provisions of the Existing Voting Agreement shall
control and supersede the provisions of this Agreement. 
 8. Notices. 

All notices, requests, demands, claims, and other communications hereunder shall be in writing. Any notice, request, demand, claim, or other
communication hereunder shall be deemed duly delivered four business days after it is sent by registered or certified mail, return receipt requested, postage prepaid, or one business day after it is sent for next business day delivery via a
reputable nationwide overnight courier service, in each case to the intended recipient as set forth below: 
  

			
	If to the Seller:	  	Copy to:
		
	 Potentia Pharmaceuticals, Inc.
 6400 Westwind
Way, Suite A
 Crestwood, KY 40014
 Attn: David M. Darst,
Director
	  	 Frost Brown Todd LLC
 400 W. Market Street,
Suite 3200
 Louisville, KY 40202
 Attn: Alan K.
MacDonald

		
	If to the Buyer:	  	Copy to:
		
	 Apellis Pharmaceuticals, Inc.
 6400 Westwind
Way, Suite A
 Crestwood, KY 40014
 Attn: Cedric Francois,
CEO
	  	 WilmerHale
 60 State Street

Boston, MA 02109
 Attn: Stuart Falber.

 Either Party may give any notice, request, demand, claim, or other communication hereunder using any other
means (including personal delivery, expedited courier, messenger service, telecopy, ordinary mail, or electronic mail), but no such notice, request, demand, claim, or other communication shall be deemed to have been duly given unless and until it
actually is received by the party for whom it is intended. Either Party may change the address to which notices, requests, demands, claims, and other communications hereunder are to be delivered by giving the other Party notice in the manner herein
set forth. 
 9. Miscellaneous. 

  
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 (a) This Agreement shall be governed by and construed in accordance with the internal laws of the
State of Delaware without giving effect to any choice or conflict of law provision or rule (whether of the State of Delaware or any other jurisdiction) that would cause the application of Laws of any jurisdiction other than those of the State of
Delaware. 
 (b) Each Party (a) submits to the exclusive personal jurisdiction of the Court of Chancery of the State of Delaware, New
Castle County, or, if that court does not have jurisdiction, a federal court sitting in Wilmington, Delaware in any action or proceeding arising out of or relating to this Agreement, (b) agrees that all claims in respect of such action or
proceeding may be heard and determined in any such court, (c) waives any claim of inconvenient forum or other challenge to venue in such court, (d) agrees not to bring any action or proceeding arising out of or relating to this Agreement
in any other court and (e) waives any right it may have to a trial by jury with respect to any action or proceeding arising out of or relating to this Agreement. Each Party agrees to accept service of any summons, complaint or other initial
pleading made in the manner provided for the giving of notices in Section 8, provided that nothing in this Section 9 shall affect the right of either Party to serve such summons, complaint or other initial pleading in any other manner
permitted by law. 
 (c) If any term or provision of this Agreement is invalid, illegal or unenforceable in any jurisdiction, such
invalidity, illegality or unenforceability shall not affect any other term or provision of this Agreement or invalidate or render unenforceable such term or provision in any other jurisdiction. Upon such determination that any term or other
provision is invalid, illegal or unenforceable, the parties hereto shall negotiate in good faith to modify this Agreement so as to effect the original intent of the parties as closely as possible in a mutually acceptable manner in order that the
transactions contemplated hereby be consummated as originally contemplated to the greatest extent possible. 
 (d) This Agreement may be
executed in one or more counterparts, each of which shall be deemed to be an original but all of which together shall constitute one and the same instrument. 

(e) Each Party shall execute and deliver such additional documents as may be necessary or desirable to effect the transactions contemplated by
this Agreement. 
 (f) All Section headings herein are for convenience of reference only and are not part of this Agreement, and no
construction or reference shall be derived therefrom. 
 (g) Neither Party may assign any of its rights or obligations under this Agreement
without the prior written consent of the other Party, except that Potentia may assign, in its sole discretion, all or any of its rights, interests and obligations hereunder to 

  
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a successor as provided in Section 4. Any assignment contrary to the provisions of this Section 9(g) shall be null and void. 

[SIGNATURE PAGE FOLLOWS] 

  
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 IN WITNESS WHEREOF, the Parties have executed and delivered this Agreement as of the date first written above.

  

			
	APELLIS PHARMACEUTICALS, INC.
		
	By:	 	 /s/ Cedric Francois

	Name:	 	Cedric Francois
	Title:	 	Chief Executive Officer
	
	POTENTIA PHARMACEUTICALS, INC.
		
	By:	 	 /s/ Cedric Francois

	Name:	 	Cedric Francois
	Title:	 	Chief Executive Officer

  
 7EX-10.1

 Exhibit 10.1 

APELLIS PHARMACEUTICALS, INC. 

2010 EQUITY INCENTIVE PLAN 

As adopted May 12, 2010. 

ARTICLE 1 
 PURPOSE

 The purpose of the Apellis Pharmaceuticals, Inc. 2010 Equity Incentive Plan (the “Plan”) is to promote the
success and enhance the value of Apellis Pharmaceuticals, Inc., a Delaware corporation (the “Company”) by linking the personal interests of the members of the Board, Employees and Consultants to those of Company stockholders and by
providing such individuals with an incentive for outstanding performance to generate superior returns to Company stockholders. The Plan is further intended to provide flexibility to the Company in its ability to motivate, attract, and retain the
services of members of the Board, Employees and Consultants upon whose judgment, interest, and special effort the successful conduct of the Company’s operation is largely dependent. 

The Board of Directors and the stockholders approved the Plan, with 2,500,000 shares of Common Stock reserved for issuance hereunder, on
May 12, 2010. 
 ARTICLE 2 

DEFINITIONS AND CONSTRUCTION 

Wherever the following terms are used in the Plan they shall have the meanings specified below, unless the context clearly indicates
otherwise. The singular pronoun shall include the plural where the context so indicates. 
 2.1 “Award” means an Option, a
Restricted Stock award, a Stock Appreciation Right award, a Performance Share award, a Performance Stock Unit award, a Dividend Equivalents award, a Stock Payment award, a Deferred Stock award, a Restricted Stock Unit award, an Other Stock-Based
Award, or a Performance Bonus Award granted to a Participant pursuant to the Plan. 
 2.2 “Award Agreement” means any written
agreement, contract, or other instrument or document evidencing an Award, including through an electronic medium. 
 2.3 “Board”
means the Board of Directors of the Company. 
 2.4 “Cause” means the occurrence of any one or more of the following:

(a) conviction of, or plea of no contest with respect to, any felony; 

(b) participation in a fraud or act of dishonesty that results in material harm to the Company; 

 (c) violation of a fiduciary duty owed to the Company; 

(d) material violation of any contract or agreement with the Company; or 

(e) failure to comply with the direct, lawful instructions of the Board or any action taken without adequate authority from the Board that has
not been cured within five (5) days after notice from the Board of such failure or action. 
 2.5 “Code” means the Internal
Revenue Code of 1986, as amended. 
 2.6 “Committee” means the committee of the Board described in Article 12. 

2.7 “Consultant” means any consultant or adviser if: 

(a) The consultant or adviser renders bona fide services to the Company; 

(b) The services rendered by the consultant or adviser are not in connection with the offer or sale of securities in a capital-raising transaction and do not directly or indirectly promote or maintain a market for the Company’s securities; and 

(c) The consultant or adviser is a natural person who has contracted directly with the Company to render such services, whether as a member of
the Company’s Scientific Advisory Board or otherwise. 
 2.8 “Covered Employee” means an Employee who is, or could be, a
“covered employee” within the meaning of Section 162(m) of the Code. 
 2.9 “Deferred Stock” means a right to
receive a specified number of shares of Stock during specified time periods pursuant to Article 8. 
 2.10 “Disability” means the
inability, in the opinion of a qualified physician acceptable to the Company, to perform the requirements of a position with the Company because of any disease or condition for a continuous period of more than 60 days or any 90 days within a 180 day
period. 
 2.11 “Dividend Equivalents” means a right granted to a Participant pursuant to Article 8 to receive the equivalent
value (in cash or Stock) of dividends paid on Stock. 
 2.12 “Effective Date” shall have the meaning set forth in
Section 13.1. 
 2.13 “Eligible Individual” means any person who is a member of the Board, an Employee or a Consultant, as
determined by the Committee. 
 2.14 “Employee” means any officer or other employee (as defined in accordance with
Section 3401(c) of the Code) of the Company or any Subsidiary. 
 2.15 “Exchange Act” means the Securities Exchange Act of
1934, as amended. 

  
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 2.16 “Fair Market Value” means, as of any given date, the fair market value of a share
of Stock on such date determined by such methods or procedures as may be established from time to time by the Committee. If the Stock is not publicly traded on an established securities market, Fair Market Value shall be determined in good faith by
the Committee by reasonable application of a reasonable valuation method, considering any and all information that the Committee deems relevant, consistent with Code Section 409A and the Treasury Regulations promulgated thereunder and
considering each of the factors required to be included under those rules, including: (i) the value of the tangible and intangible assets of the Company; (ii) the present value of anticipated future cash flow of the Company; (iii) the
market value of equity interests in similar companies and other entities engaged in trades or businesses substantially similar to those engaged in by the Company, the value of which can be readily determined through nondiscretionary objective means
(such as through trading prices on an established securities market or an amount paid in an arm’s length transaction involving the sale or transfer of such equity interests); (iv) recent arm’s length transactions involving the sale or
transfer of such equity interests; and (v) other relevant factors such as control premiums or discounts for lack of marketability and whether the valuation method is used for other purposes that have a material economic effect on the Company,
its stockholders or its creditors. If the Stock is listed on any established stock exchange or a national market system, including, without limitation, the Nasdaq National Market or The Nasdaq SmallCap Market of The Nasdaq Stock Market, its Fair
Market Value shall be the closing selling price for a share of Stock as quoted on such exchange or system for such date or, if there is no closing selling price for the Stock on the date in question, the closing selling price for a share of Stock on
the last preceding date for which such quotation exists, unless otherwise determined by the Committee. 
 2.17 “Incentive Stock
Option” means an Option that is intended to meet the requirements of Section 422 of the Code or any successor provision thereto. 

2.18 “Independent Director” means a member of the Board who is not an Employee of the Company. 

2.19 “Non-Qualified Stock Option” means an Option that is not intended to be an Incentive Stock Option. 

2.20 “Option” means a right granted to a Participant pursuant to Article 5 of the Plan to purchase a specified number of shares of
Stock at a specified price during specified time periods. An Option may be either an Incentive Stock Option or a Non-Qualified Stock Option. 

2.21 “Other Stock-Based Award” means an Award granted or denominated in Stock or units of Stock pursuant to Section 8.7 of the
Plan. 
 2.22 “Participant” means any Eligible Individual who, as a member of the Board, Consultant or Employee, has been granted
an Award pursuant to the Plan. 
 2.23 “Performance-Based Award” means an Award granted to selected Covered Employees pursuant to
Articles 6 and 8, but which is subject to the terms and conditions set forth in Article 9. All Performance-Based Awards are intended to qualify as Qualified Performance-Based Compensation. 

  
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 2.24 “Performance Bonus Award” has the meaning set forth in Section 8.8. 

2.25 “Performance Criteria” means the criteria that the Committee selects for purposes of establishing the Performance Goal or
Performance Goals for a Participant for a Performance Period. The Performance Criteria that will be used to establish Performance Goals are limited to the following: net earnings (either before or after interest, taxes, depreciation and
amortization), economic value-added (as determined by the Committee), sales or revenue, net income (either before or after taxes), operating earnings, cash flow (including, but not limited to, operating cash
flow and free cash flow), cash flow return on capital, return on net assets, return on stockholders’ equity, return on assets, return on capital, stockholder returns, return on sales, gross or net profit margin, productivity, expense, margins,
operating efficiency, customer satisfaction, working capital, earnings per share, price per share of Stock, and market share, any of which may be measured either in absolute terms or as compared to any incremental increase or as compared to results
of a peer group. The Committee shall, within the time prescribed by Section 162(m) of the Code, define in an objective fashion the manner of calculating the Performance Criteria it selects to use for such Performance Period for such
Participant. 
 2.26 “Performance Goals” means, for a Performance Period, the goals established in writing by the Committee for
the Performance Period based upon the Performance Criteria. Depending on the Performance Criteria used to establish such Performance Goals, the Performance Goals may be expressed in terms of overall Company performance or the performance of a
division, business unit, or an individual. The Committee, in its discretion, may, within the time prescribed by Section 162(m) of the Code, adjust or modify the calculation of Performance Goals for such Performance Period in order to prevent
the dilution or enlargement of the rights of Participants (a) in the event of, or in anticipation of, any unusual or extraordinary corporate item, transaction, event, or development, or (b) in recognition of, or in anticipation of, any
other unusual or nonrecurring events affecting the Company, or the financial statements of the Company, or in response to, or in anticipation of, changes in applicable laws, regulations, accounting principles, or business conditions. 

2.27 “Performance Period” means the one or more periods of time, which may be of varying and overlapping durations, as the Committee
may select, over which the attainment of one or more Performance Goals will be measured for the purpose of determining a Participant’s right to, and the payment of, a Performance-Based Award. 

2.28 “Performance Share” means a right granted to a Participant pursuant to Article 8, to receive Stock, the payment of which is
contingent upon achieving certain Performance Goals or other performance-based targets established by the Committee. 
 2.29
“Performance Stock Unit” means a right granted to a Participant pursuant to Article 8, to receive Stock, the payment of which is contingent upon achieving certain Performance Goals or other performance-based targets established by the
Committee. 
 2.30 “Permitted Transferee” has the meaning set forth in Section 10.3. 

2.31 “Plan” means this Apellis Pharmaceuticals, Inc. 2010 Equity Incentive Plan, as it may be amended from time to time. 

  
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 2.32 “Public Trading Date” means the first date upon which Stock is listed (or approved
for listing) upon notice of issuance on any securities exchange or designated (or approved for designation) upon notice of issuance as a national market security on an interdealer quotation system. 

2.33 “Qualified Performance-Based Compensation” means any compensation that is intended to qualify as “qualified
performance-based compensation” as described in Section 162(m)(4)(C) of the Code. 
 2.34 “Restricted Stock” means Stock
awarded to a Participant pursuant to Article 6 that is subject to certain restrictions and may be subject to risk of forfeiture. 
 2.35
“Restricted Stock Unit” means an Award granted pursuant to Section 8.6. 
 2.36 “Securities Act” shall mean the
Securities Act of 1933, as amended. 
 2.37 “Stock” means the common stock of the Company, $0.0001 par value per share, and such
other securities of the Company that may be substituted for Stock pursuant to Article 11. 
 2.38 “Stock Appreciation Right” or
“SAR” means a right granted pursuant to Article 7 to receive a payment equal to the excess of the Fair Market Value of a specified number of shares of Stock on the date the SAR is exercised over the Fair Market Value on the date the SAR
was granted as set forth in the applicable Award Agreement. 
 2.39 “Stock Payment” means (a) a payment in the form of shares
of Stock, or (b) an option or other right to purchase shares of Stock, as part of any bonus, deferred compensation or other arrangement, made in lieu of all or any portion of the Participant’s compensation, granted pursuant to Article 8.

 2.40 “Subsidiary” means any “subsidiary corporation” as defined in Section 424(f) of the Code and any applicable
regulations promulgated thereunder or any other entity of which a majority of the outstanding voting stock or voting power is beneficially owned directly or indirectly by the Company. 

2.41 “Termination of Employment” means for any Employee, the cessation of employment from the Company, whether initiated by the
Company or the Employee, voluntary or involuntary, or with or without Cause, for any reason, including without limitation death, Disability, termination or resignation. 

2.42 “Termination of Directorship” means for any member of the Board, the removal of such individual from the Board, whether
voluntary or involuntary, or with or without Cause, for any reason, including death, Disability, resignation or removal. 
 2.43
“Termination of Consultancy” means for any Consultant, the cessation services for the Company, whether initiated by the Company or the Consultant, voluntary or involuntary, or with or without Cause, for any reason, including without
limitation death, Disability, termination or resignation. 

  
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 ARTICLE 3 

SHARES SUBJECT TO THE PLAN 

3.1 Number of Shares. 

(a) Subject to Article 11 and Section 3.1(b), the maximum aggregate number of shares of Stock which may be issued or transferred pursuant
to Awards under the Plan shall be 2,500,000 shares. 
 (b) To the extent that an Award terminates, expires, or lapses for any reason, any
shares of Stock subject to the Award shall again be available for the grant of an Award pursuant to the Plan. Additionally, any shares of Stock tendered or withheld to satisfy the grant or exercise price or tax withholding obligation pursuant to any
Award shall again be available for the grant of an Award pursuant to the Plan. To the extent permitted by applicable law or any exchange rule, shares of Stock issued in assumption of, or in substitution for, any outstanding awards of any entity
acquired in any form of combination by the Company or any Subsidiary shall not be counted against shares of Stock available for grant pursuant to this Plan. 

3.2 Stock Distributed. Any Stock distributed pursuant to an Award may consist, in whole or in part, of authorized and unissued Stock,
treasury Stock or reacquired Stock. 
 3.3 Limitation on Number of Shares Subject to Awards. Notwithstanding any provision in the
Plan to the contrary, and subject to Article 11, the maximum number of shares of Stock with respect to one or more Awards that may be granted to any one Participant during a rolling three-year period (measured from the date of any grant) shall be
1,250,000. 
 ARTICLE 4 

ELIGIBILITY AND PARTICIPATION 

4.1 Eligibility. Each Eligible Individual shall be eligible to be granted one or more Awards pursuant to the Plan. 

4.2 Participation. Subject to the provisions of the Plan, the Committee may, from time to time, select from among all Eligible
Individuals, those to whom Awards shall be granted and shall determine the nature and amount of each Award. No Eligible Individual shall have any right to be granted an Award pursuant to this Plan. 

4.3 Foreign Participants. In order to assure the viability of Awards granted to Participants employed in foreign countries, the
Committee may provide for such special terms as it may consider necessary or appropriate to accommodate differences in local law, tax policy, or custom. Moreover, the Committee may approve such supplements to, or amendments, restatements, or
alternative versions of, the Plan as it may consider necessary or appropriate for such purposes without thereby affecting the terms of the Plan as in effect for any other purpose; 

  
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provided, however, that no such supplements, amendments, restatements, or alternative versions shall increase the share limitations contained in Sections 3.1 and 3.3 of the Plan. 

ARTICLE 5 
 STOCK
OPTIONS 
 5.1 General. The Committee is authorized to grant Options to Participants on the following terms and conditions:

 (a) Exercise Price. The exercise price per share of Stock subject to an Option shall be determined by the Committee and set forth
in the Award Agreement; provided that the exercise price for any Option shall not be less than one hundred percent (100%) of the Fair Market Value of a share of Stock on the date of grant. 

(b) Time and Conditions of Exercise. The Committee shall determine the time or times at which an Option may be exercised in whole or in
part; provided, that the term of any Option granted under the Plan shall not exceed ten (10) years. The Committee shall also determine the performance or other conditions, if any, that must be satisfied before all or part of an Option may be
exercised. 
 (c) Payment. The Committee shall determine the methods by which the exercise price of an Option may be paid, the form
of payment, including, without limitation: (i) cash, (ii) shares of Stock held for such period of time as may be required by the Committee in order to avoid adverse accounting consequences and having a Fair Market Value on the date of
delivery equal to the aggregate exercise price of the Option or exercised portion thereof, or (iii) other property acceptable to the Committee (including through the delivery of a notice that the Participant has placed a market sell order with
a broker with respect to shares of Stock then issuable upon exercise of the Option, and that the broker has been directed to pay a sufficient portion of the net proceeds of the sale to the Company in satisfaction of the Option exercise price;
provided that payment of such proceeds is then made to the Company upon settlement of such sale), and the methods by which shares of Stock shall be delivered or deemed to be delivered to Participants. Notwithstanding any other provision of the Plan
to the contrary, no Participant who is a member of the Board or an “executive officer” of the Company within the meaning of Section 13(k) of the Exchange Act shall be permitted to pay the exercise price of an Option in any method
which would violate Section 13(k) of the Exchange Act. 
 (d) Evidence of Grant. All Options shall be evidenced by a written
Award Agreement between the Company and the Participant. The Award Agreement shall include such additional provisions as may be specified by the Committee. 

5.2 Incentive Stock Options. The terms of any Incentive Stock Options granted pursuant to the Plan must comply with the conditions and
limitations contained Section 13.2 and this Section 5.2. 
 (a) Eligibility. Incentive Stock Options may be granted only to
employees of the Company or any “subsidiary corporation” thereof (within the meaning of Section 424(f) of the Code and the applicable regulations promulgated thereunder). 

  
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 (b) Exercise Price. The exercise price per share of Stock shall be set by the Committee;
provided that subject to Section 5.2(d) the exercise price for any Incentive Stock Option shall not be less than one hundred percent (100%) of the Fair Market Value on the date of grant. 

(c) Individual Dollar Limitation. The aggregate Fair Market Value (determined as of the time the Option is granted) of all shares of
Stock with respect to which Incentive Stock Options are first exercisable by a Participant in any calendar year may not exceed $100,000 or such other limitation as imposed by Section 422(d) of the Code, or any successor provision. To the extent
that Incentive Stock Options are first exercisable by a Participant in excess of such limitation, the excess shall be considered Non-Qualified Stock Options. 

(d) Ten Percent Owners. An Incentive Stock Option shall be granted to any individual who, at the date of grant, owns stock possessing
more than ten percent (10%) of the total combined voting power of all classes of Stock of the Company only if such Option is granted at a price that is not less than one hundred ten percent (110%) of Fair Market Value on the date of grant
and the Option is exercisable for no more than five (5) years from the date of grant. 
 (e) Notice of Disposition. In the event
that a Participant acquires shares of Stock by exercise of an Incentive Stock Option, such Participant shall give the Company prompt notice of any disposition of such shares of Stock within (i) two (2) years from the date of grant of such
Incentive Stock Option or (ii) one (1) year after the transfer of such shares of Stock to the Participant. 
 (f) Right to
Exercise. During a Participant’s lifetime, an Incentive Stock Option may be exercised only by the Participant. 
 5.3
Substitution of Stock Appreciation Rights. The Committee may provide in the Award Agreement evidencing the grant of an Option that the Committee, in its sole discretion, shall have to right to substitute a Stock Appreciation Right for such
Option at any time prior to or upon exercise of such Option, subject to the provisions of Section 7.2 hereof; provided that such Stock Appreciation Right shall be exercisable with respect to the same number of shares of Stock for which such
substituted Option would have been exercisable. 
 5.4 Paperless Exercise. In the event that the Company establishes, for itself or
using the services of a third party, an automated system for the exercise of Options, such as a system using an internet website or interactive voice response, then the paperless exercise of options by a Participant may be permitted through the use
of such an automated system. 
 5.5 Granting of Options to Independent Directors. The Board may from time to time, in its sole
discretion, and subject to the limitations of the Plan: 
 (a) Select from among the Independent Directors (including Independent Directors
who have previously been granted Options under the Plan) such of them as in its opinion should be granted Options; 

  
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 (b) Subject to Section 3.3, determine the number of shares of Stock that may be purchased
upon exercise of the Options granted to such selected Independent Directors; and 
 (c) Subject to the provisions of this Article 5,
determine the terms and conditions of such Options, consistent with the Plan. 
 Options granted to Independent Directors shall be Non-Qualified Stock
Options. 
 ARTICLE 6 

RESTRICTED STOCK AWARDS 

6.1 Grant of Restricted Stock. The Committee is authorized to make Awards of Restricted Stock to any Participant selected by the
Committee in such amounts and subject to such terms and conditions as determined by the Committee. All Awards of Restricted Stock shall be evidenced by a written Restricted Stock Award Agreement. 

6.2 Issuance and Restrictions. Restricted Stock shall be subject to such restrictions on transferability and other restrictions as the
Committee may impose (including, without limitation, limitations on the right to vote Restricted Stock or the right to receive dividends on the Restricted Stock). These restrictions may lapse separately or in combination at such times, pursuant to
such circumstances, in such installments, or otherwise, as the Committee determines at the time of the grant of the Award or thereafter. 

6.3 Forfeiture. Except as otherwise determined by the Committee at the time of the grant of the Award or thereafter, upon Termination
of Employment, Termination of Directorship or Termination of Consultancy (as applicable) during the applicable restriction period, Restricted Stock that is at that time subject to restrictions shall be forfeited; provided, however, that the
Committee may (a) provide in any Restricted Stock Award Agreement that restrictions or forfeiture conditions relating to Restricted Stock will be waived in whole or in part in the event of terminations resulting from specified causes, and
(b) in other cases waive in whole or in part restrictions or forfeiture conditions relating to Restricted Stock. 
 6.4 Certificates
for Restricted Stock. Restricted Stock granted pursuant to the Plan may be evidenced in such manner as the Committee shall determine. If certificates representing shares of Restricted Stock are registered in the name of the Participant,
certificates must bear an appropriate legend referring to the terms, conditions, and restrictions applicable to such Restricted Stock, and the Company may, at its discretion, retain physical possession of the certificate until such time as all
applicable restrictions lapse. 
 ARTICLE 7 

STOCK APPRECIATION RIGHTS 

7.1 Grant of Stock Appreciation Rights. A Stock Appreciation Right may be granted to any Participant selected by the Committee. A Stock
Appreciation Right may be granted (a) in connection and simultaneously with the grant of an Option, (b) with respect to a previously granted Option, or (c) independent of an Option. A Stock Appreciation Right shall be subject to

  
 9 

 
such terms and conditions not inconsistent with the Plan as the Committee shall impose and shall be evidenced by an Award Agreement. 

7.2 Coupled Stock Appreciation Rights. 

(a) A Coupled Stock Appreciation Right (“CSAR”) shall be related to a particular Option and shall be exercisable only when and
to the extent the related Option is exercisable. 
 (b) A CSAR may be granted to a Participant for no more than the number of shares subject
to the simultaneously granted Option to which it is coupled. 
 (c) A CSAR shall entitle the Participant (or other person entitled to
exercise the Option pursuant to the Plan) to surrender to the Company the unexercised portion of the Option to which the CSAR relates (to the extent then exercisable pursuant to its terms) and to receive from the Company in exchange therefor an
amount determined by multiplying the difference obtained by subtracting the Option exercise price from the Fair Market Value of a share of Stock on the date of exercise of the CSAR by the number of shares of Stock with respect to which the CSAR
shall have been exercised, subject to any limitations the Committee may impose. 
 7.3 Independent Stock Appreciation Rights. 

(a) An Independent Stock Appreciation Right (“ISAR”) shall be unrelated to any Option and shall have a term set by the
Committee. An ISAR shall be exercisable in such installments as the Committee may determine. An ISAR shall cover such number of shares of Stock as the Committee may determine. The exercise price per share of Stock subject to each ISAR shall be set
by the Committee; provided, however, that the exercise price for any ISAR shall not be less than one hundred percent (100%) of the Fair Market Value on the date of grant; and provided, further, that the Committee in its sole and
absolute discretion may provide that the ISAR may be exercised subsequent to a Termination of Employment, Termination of Directorship or Termination of Consultancy (as applicable), or following a merger, consolidation or other similar transaction
involving the Company, or because of the Participant’s retirement, death or Disability, or otherwise. 
 (b) An ISAR shall entitle the
Participant (or other person entitled to exercise the ISAR pursuant to the Plan) to exercise all or a specified portion of the ISAR (to the extent then exercisable pursuant to its terms) and to receive from the Company an amount determined by
multiplying the difference obtained by subtracting the exercise price per share of the ISAR from the Fair Market Value of a share of Stock on the date of exercise of the ISAR by the number of shares of Stock with respect to which the ISAR shall have
been exercised, subject to any limitations the Committee may impose. 
 7.4 Payment and Limitations on Exercise. 

(a) Payment of the amounts determined under Sections 7.2(c) and 7.3(b) above shall be in cash, in Stock (based on its Fair Market Value as of
the date the Stock Appreciation Right is exercised) or a combination of both, as determined by the Committee. 

  
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 (b) To the extent payment for a Stock Appreciation Right is to be made in cash, the Award
Agreement shall, to the extent necessary to comply with the requirements to Section 409A of the Code, specify the date of payment which may be different than the date of exercise of the Stock Appreciation Right. If the date of payment for a
Stock Appreciation Right is later than the date of exercise, the Award Agreement may specify that the Participant be entitled to earnings on such amount until paid. 

(c) To the extent any payment under Section 7.2(c) or 7.3(b) is effected in Stock it shall be made subject to satisfaction of all
provisions of Article 5 above pertaining to Options. 
 ARTICLE 8 

OTHER TYPES OF AWARDS 

8.1 Performance Share Awards. Any Participant selected by the Committee may be granted one or more Performance Share awards which shall
be denominated in a number of shares of Stock and which may be linked to any one or more of the Performance Criteria or other specific performance criteria determined appropriate by the Committee, in each case on a specified date or dates or over
any period or periods determined by the Committee. In making such determinations, the Committee shall consider (among such other factors as it deems relevant in light of the specific type of award) the contributions, responsibilities and other
compensation of the particular Participant. 
 8.2 Performance Stock Units. Any Participant selected by the Committee may be granted
one or more Performance Stock Unit awards which shall be denominated in units of value including dollar value of shares of Stock and which may be linked to any one or more of the Performance Criteria or other specific performance criteria determined
appropriate by the Committee, in each case on a specified date or dates or over any period or periods determined by the Committee. In making such determinations, the Committee shall consider (among such other factors as it deems relevant in light of
the specific type of award) the contributions, responsibilities and other compensation of the particular Participant. 
 8.3 Dividend
Equivalents. 
 (a) Any Participant selected by the Committee may be granted Dividend Equivalents based on the dividends declared on the
shares of Stock that are subject to any Award, to be credited as of dividend payment dates, during the period between the date the Award is granted and the date the Award is exercised, vests or expires, as determined by the Committee. Such Dividend
Equivalents shall be converted to cash or additional shares of Stock by such formula and at such time and subject to such limitations as may be determined by the Committee. 

(b) Dividend Equivalents granted with respect to Options or SARs that are intended to be Qualified Performance-Based Compensation shall be
payable, with respect to pre-exercise periods, regardless of whether such Option or SAR is subsequently exercised. 

  
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 8.4 Stock Payments. Any Participant selected by the Committee may receive Stock Payments
in the manner determined from time to time by the Committee. The number of shares shall be determined by the Committee and may be based upon the Performance Criteria or other specific performance criteria determined appropriate by the Committee,
determined on the date such Stock Payment is made or on any date thereafter. 
 8.5 Deferred Stock. Any Participant selected by the
Committee may be granted an award of Deferred Stock in the manner determined from time to time by the Committee. The number of shares of Deferred Stock shall be determined by the Committee and may be linked to the Performance Criteria or other
specific performance criteria determined to be appropriate by the Committee, in each case on a specified date or dates or over any period or periods determined by the Committee. Stock underlying a Deferred Stock award will not be issued until the
Deferred Stock award has vested, pursuant to a vesting schedule or performance criteria set by the Committee. Unless otherwise provided by the Committee, a Participant awarded Deferred Stock shall have no rights as a Company stockholder with respect
to such Deferred Stock until such time as the Deferred Stock Award has vested and the Stock underlying the Deferred Stock Award has been issued. 

8.6 Restricted Stock Units. The Committee is authorized to make Awards of Restricted Stock Units to any Participant selected by the
Committee in such amounts and subject to such terms and conditions as determined by the Committee. At the time of grant, the Committee shall specify the date or dates on which the Restricted Stock Units shall become fully vested and nonforfeitable,
and may specify such conditions to vesting as it deems appropriate. At the time of grant, the Committee shall specify the maturity date applicable to each grant of Restricted Stock Units which shall be no earlier than the vesting date or dates of
the Award and, subject to compliance with the requirements of Section 409A of the Code, may be determined at the election of the grantee. On the maturity date, the Company shall, subject to Section 10.5(b), transfer to the Participant one
(1) unrestricted, fully transferable share of Stock for each Restricted Stock Unit scheduled to be paid out on such date and not previously forfeited. The Committee shall specify the purchase price, if any, to be paid by the grantee to the
Company for such shares of Stock. 
 8.7 Other Stock-Based Awards. Any Participant selected by the Committee may be granted one or
more Awards that provide Participants with shares of Stock or the right to purchase shares of Stock or that have a value derived from the value of, or an exercise or conversion privilege at a price related to, or that are otherwise payable in shares
of Stock and which may be linked to any one or more of the Performance Criteria or other specific performance criteria determined appropriate by the Committee, in each case on a specified date or dates or over any period or periods determined by the
Committee. In making such determinations, the Committee shall consider (among such other factors as it deems relevant in light of the specific type of Award) the contributions, responsibilities and other compensation of the particular Participant.

 8.8 Performance Bonus Awards. Any Participant selected by the Committee may be granted one or more Awards in the form of a cash
bonus (a “Performance Bonus Award”) payable with respect to any period of employment and based upon any performance criteria and subject to any terms and conditions that the Committee may determine, in its sole discretion.

  
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The payment of bonuses pursuant to this Section 8.8 shall be made on any date or dates determined by the Committee and subject to any terms and conditions determined by the Committee, in its
sole discretion. 
 8.9 Term. Except as otherwise provided herein, the term of any Award of Performance Shares, Performance Stock
Units, Dividend Equivalents, Stock Payments, Deferred Stock, Restricted Stock Units or Other Stock-Based Award shall be set by the Committee in its discretion. 

8.10 Exercise or Purchase Price. The Committee may establish the exercise or purchase price, if any, of any Award of Performance
Shares, Performance Stock Units, Deferred Stock, Stock Payments, Restricted Stock Units or Other Stock-Based Award; provided, however, that such price shall not be less than the par value of a share of Stock on the date of grant, unless
otherwise permitted by applicable state law. 
 8.11 Exercise Upon Termination of Employment or Service. An Award of Performance
Shares, Performance Stock Units, Dividend Equivalents, Deferred Stock, Stock Payments, Restricted Stock Units and Other Stock-Based Award shall only be exercisable or payable while the Participant is an Employee, Consultant or a member of the Board,
as applicable; provided, however, that the Committee in its sole and absolute discretion may provide that an Award of Performance Shares, Performance Stock Units, Dividend Equivalents, Stock Payments, Deferred Stock, Restricted Stock Units or
Other Stock-Based Award may be exercised or paid subsequent to a Termination of Employment, Termination of Directorship or Termination of Consultancy (as applicable), as applicable, or following a merger, consolidation or other similar transaction
involving the Company, or because of the Participant’s retirement, death or Disability, or otherwise; provided, however, that any such provision with respect to Performance Shares or Performance Stock Units shall be subject to the
requirements of Section 162(m) of the Code that apply to Qualified Performance-Based Compensation. 
 8.12 Form of Payment.
Payments with respect to any Awards granted under this Article 8 shall be made in cash, in Stock or a combination of both, as determined by the Committee. 

8.13 Award Agreement. All Awards under this Article 8 shall be subject to such additional terms and conditions as determined by the
Committee and shall be evidenced by a written Award Agreement. Such Award Agreement shall include a Code Section 409A payment date or schedule as well as any other terms required for compliance with Code Section 409A and the regulations
promulgated thereunder. 
 ARTICLE 9 

PERFORMANCE-BASED AWARDS 

9.1 Purpose. The purpose of this Article 9 is to provide the Committee the ability to qualify Awards other than Options and SARs and
that are granted pursuant to Articles 6 and 8 as Qualified Performance-Based Compensation. If the Committee, in its discretion, decides to grant a Performance-Based Award to a Covered Employee, the provisions of this Article 9 shall control over any
contrary provision contained in Articles 6 or 8; provided, however, that the 

  
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Committee may in its discretion grant Awards to Covered Employees that are based on Performance Criteria or Performance Goals but that do not satisfy the requirements of this Article 9. 

9.2 Applicability. This Article 9 shall apply only to those Covered Employees selected by the Committee to receive Performance-Based
Awards. The designation of a Covered Employee as a Participant for a Performance Period shall not in any manner entitle the Participant to receive an Award for the period. Moreover, designation of a Covered Employee as a Participant for a particular
Performance Period shall not require designation of such Covered Employee as a Participant in any subsequent Performance Period and designation of one Covered Employee as a Participant shall not require designation of any other Covered Employees as
a Participant in such period or in any other period. 
 9.3 Procedures with Respect to Performance-Based Awards. To the extent
necessary to comply with the Qualified Performance-Based Compensation requirements of Section 162(m)(4)(C) of the Code, with respect to any Award granted under Articles 6 and 8 which may be granted to one or more Covered Employees, no later
than ninety (90) days following the commencement of any fiscal year in question or any other designated fiscal period or period of service (or such other time as may be required or permitted by Section 162(m) of the Code), the Committee
shall, in writing, (a) designate one or more Covered Employees, (b) select the Performance Criteria applicable to the Performance Period, (c) establish the Performance Goals, and amounts of such Awards, as applicable, which may be
earned for such Performance Period, and (d) specify the relationship between Performance Criteria and the Performance Goals and the amounts of such Awards, as applicable, to be earned by each Covered Employee for such Performance Period.
Following the completion of each Performance Period, the Committee shall certify in writing whether the applicable Performance Goals have been achieved for such Performance Period. In determining the amount earned by a Covered Employee, the
Committee shall have the right to reduce or eliminate (but not to increase) the amount payable at a given level of performance to take into account additional factors that the Committee may deem relevant to the assessment of individual or corporate
performance for the Performance Period. 
 9.4 Payment of Performance-Based Awards. Unless otherwise provided in the applicable Award
Agreement, a Participant must be employed by the Company or a Subsidiary on the day a Performance-Based Award for such Performance Period is paid to the Participant. Furthermore, a Participant shall be eligible to receive payment pursuant to a
Performance-Based Award for a Performance Period only if the Performance Goals for such period are achieved. 
 9.5 Additional
Limitations. Notwithstanding any other provision of the Plan, any Award which is granted to a Covered Employee and is intended to constitute Qualified Performance-Based Compensation shall be subject to any additional limitations set forth in
Section 162(m) of the Code (including any amendment to Section 162(m) of the Code) or any regulations or rulings issued thereunder that are requirements for qualification as qualified performance-based compensation as described in
Section 162(m)(4)(C) of the Code, and the Plan shall be deemed amended to the extent necessary to conform to such requirements. 
 9.6
Award Agreement. All Awards under this Article 9 shall be subject to such additional terms and conditions as determined by the Committee and shall be evidenced by a 

  
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written Award Agreement. Such Award Agreement shall include a Code Section 409A payment date or schedule as well as any other terms required for compliance with Code Section 409A and
the regulations promulgated thereunder. 
 ARTICLE 10 

PROVISIONS APPLICABLE TO AWARDS 

10.1 Stand-Alone and Tandem Awards. Awards granted pursuant to the Plan may, in the discretion of the Committee, be granted either
alone, in addition to, or in tandem with, any other Award granted pursuant to the Plan. Awards granted in addition to or in tandem with other Awards must be granted at the same time as the grant of such other Awards. 

10.2 Award Agreement. Awards under the Plan shall be evidenced by Award Agreements that set forth the terms, conditions and limitations
for each Award which may include the term of an Award, the provisions applicable in the event the Participant’s employment or service terminates, and the Company’s authority to unilaterally or bilaterally amend, modify, suspend, cancel or
rescind an Award. 
 10.3 Limits on Transfer. No right or interest of a Participant in any Award may be pledged, encumbered, or
hypothecated to or in favor of any party other than the Company or a Subsidiary, or shall be subject to any lien, obligation, or liability of such Participant to any other party other than the Company or a Subsidiary. Except as otherwise provided by
the Committee, no Award shall be assigned, transferred, or otherwise disposed of by a Participant other than by will or the laws of descent and distribution. The Committee by express provision in the Award or an amendment thereto may permit an Award
(other than an Incentive Stock Option) to be transferred to, exercised by and paid to certain persons or entities (each a “Permitted Transferee”) related to the Participant, including but not limited to members of the
Participant’s family, charitable institutions, or trusts or other entities whose beneficiaries or beneficial owners are members of the Participant’s family and/or charitable institutions, or to such other persons or entities as may be
expressly approved by the Committee, pursuant to such conditions and procedures as the Committee may establish. Any permitted transfer shall be subject to the condition that the Committee receive evidence satisfactory to it that the transfer is
being made for estate and/or tax planning purposes (or to a “blind trust” in connection with the Participant’s termination of employment or service with the Company or a Subsidiary to assume a position with a governmental, charitable,
educational or similar non-profit institution) and on a basis consistent with the Company’s lawful issue of securities. 
 10.4
Beneficiaries. Notwithstanding Section 10.3, a Participant may, in the manner determined by the Committee, designate a beneficiary to exercise the rights of the Participant and to receive any distribution with respect to any Award upon
the Participant’s death. A beneficiary, legal guardian, legal representative, or other person claiming any rights pursuant to the Plan is subject to all terms and conditions of the Plan and any Award Agreement applicable to the Participant,
except to the extent the Plan and Award Agreement otherwise provide, and to any additional restrictions deemed necessary or appropriate by the Committee. If the Participant is married and resides in a community property state, a designation of a
person other than the Participant’s spouse as his or her beneficiary with respect to more than fifty percent (50%) of the 

  
 15 

 
Participant’s interest in the Award shall not be effective without the prior written consent of the Participant’s spouse. If no beneficiary has been designated or survives the
Participant, payment shall be made to the person entitled thereto pursuant to the Participant’s will or the laws of descent and distribution. Subject to the foregoing, a beneficiary designation may be changed or revoked by a Participant at any
time provided the change or revocation is filed with the Committee. 
 10.5 Stock Certificates; Book Entry Procedures. 

(a) Notwithstanding anything herein to the contrary, the Company shall not be required to issue or deliver any certificates evidencing shares
of Stock pursuant to the exercise of any Award, unless and until the Board has determined, with advice of counsel, that the issuance and delivery of such certificates is in compliance with all applicable laws, regulations of governmental authorities
and, if applicable, the requirements of any exchange on which the shares of Stock are listed or traded. All Stock certificates delivered pursuant to the Plan are subject to any stop-transfer orders and other restrictions as the Committee deems
necessary or advisable to comply with federal, state, or foreign jurisdiction, securities or other laws, rules and regulations and the rules of any national securities exchange or automated quotation system on which the Stock is listed, quoted, or
traded. The Committee may place legends on any Stock certificate to reference restrictions applicable to the Stock. In addition to the terms and conditions provided herein, the Board may require that a Participant make such reasonable covenants,
agreements, and representations as the Board, in its discretion, deems advisable in order to comply with any such laws, regulations, or requirements. The Committee shall have the right to require any Participant to comply with any timing or other
restrictions with respect to the settlement or exercise of any Award, including a window-period limitation, as may be imposed in the discretion of the Committee. 

(b) Notwithstanding any other provision of the Plan, unless otherwise determined by the Committee or required by any applicable law, rule or
regulation, the Company shall not deliver to any Participant certificates evidencing shares of Stock issued in connection with any Award and instead such shares of Stock shall be recorded in the books of the Company (or, as applicable, its transfer
agent or stock plan administrator). 
 ARTICLE 11 

CHANGE OF CONTROL TRANSACTIONS 

AND OTHER CHANGES TO CAPITAL STRUCTURE 

11.1 Adjustments for Change of Control Transactions. 

(a) For the purposes of Sections 5, 6 and 7 only, the term “Change of Control” have the meaning of any transaction deemed to
be liquidation under Article IV.B.2 of the Company’s Certificate of Incorporation, as amended. With respect to Awards granted under Sections 8 and 9, the Award Agreements shall contain a definition of “Change of Control” similar in
substance to the above definition with such modifications or alterations as may be required for compliance with Section 409A of the Code and the Treasury Regulations promulgated thereunder. 

  
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 (b) Immediately prior to any Change of Control or at such earlier date as provided for in
subsection (b)(iii), any outstanding Awards then held by Participants which are unexercisable or otherwise unvested or subject to lapse restrictions shall automatically be deemed exercisable or vested or no longer subject to lapse restrictions (as
the case may be), and prior to such Change of Control, the Committee shall take one of the following actions with respect to each Award issued under the Plan: 

(i) to provide for the termination of such Award in exchange for a cash payment equal to the fair value thereof (as determined in the sole
discretion of the Committee), which in the case of an Option will equal the excess, if any, of the value of the consideration to be paid in the Change of Control event to holders of the same number of shares of Stock subject to such Option over the
aggregate exercise price of such Option (for the avoidance of doubt, if as of the date of the occurrence of the event described in this Section 11.1(b) the Committee determines in good faith that no amount would have been attained upon the
exercise of such Award or realization of the Participant’s rights, then such Award may be terminated by the Company without payment); 

(ii) to provide that such Award shall be canceled and the Participant shall receive in substitution therefor similar fully vested options,
rights or awards covering the stock of the successor or surviving or acquiring entity, or a parent or subsidiary thereof, with appropriate adjustments as to the number and kind of shares and prices; 

(iii) to provide, with respect to any Award that must be exercised to obtain the benefits thereunder, that for a period of at least 15 days
prior to the Change of Control, such Award shall be exercisable as to all shares of Stock subject thereto and that upon the occurrence of the Change of Control, such Award shall terminate and be of no further force and effect; or 

(iv) if the Change of Control occurs and the Company is the surviving entity in a reorganization, merger or consolidation, to specify that
the Award, now fully vested and exercisable, shall remain outstanding upon the other terms stated in the applicable Award Agreement. 
 11.2
Adjustments for Other Changes to Capital Structure. In the event of any change in the outstanding shares of Stock after the Effective Date by reason of any stock dividend or split, reorganization, recapitalization, merger, consolidation,
spin-off, combination, combination or transaction or exchange of shares of Stock or other corporate exchange, or any distribution to stockholders of shares of Stock or cash other than regular cash dividends or any transaction similar to the
foregoing, the Committee in its sole discretion and without liability to any person shall make such substitution or adjustment, if any, as it deems to be equitable, as to: (i) the number of kind of shares of Stock or other securities issued or
reserved for issuance pursuant to the Plan or pursuant to outstanding Awards; (ii) the maximum number of shares of Stock for which Options or Stock Appreciation Rights may be granted during a calendar year to any Participant; (iii) the
maximum amount of a Performance-Based Award that may be granted during a calendar year to any Participant; (iv) the exercise price of any Option or Stock Appreciation Right; and/or (v) any other affected terms of such Awards. 

  
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 11.3 No Other Rights. Except as expressly provided in the Plan, no Participant shall have
any rights by reason of any subdivision or consolidation of shares of stock of any class, the payment of any dividend, any increase or decrease in the number of shares of stock of any class or any dissolution, liquidation, merger, or consolidation
of the Company or any other entity. Except as expressly provided in the Plan or pursuant to action of the Committee under the Plan, no issuance by the Company of shares of stock of any class, or securities convertible into shares of stock of any
class, shall affect, and no adjustment by reason thereof shall be made with respect to, the number of shares of Stock subject to an Award or the grant or exercise price of any Award. 

ARTICLE 12 

ADMINISTRATION 

12.1 Committee. Unless and until the Board delegates administration of the Plan to a Committee as set forth below, the Plan shall be
administered by the full Board, and for such purposes the term “Committee” as used in this Plan shall be deemed to refer to the Board. The Board, at its discretion or as otherwise necessary to comply with the requirements of
Section 162(m) of the Code, Rule 16b-3 promulgated under the Exchange Act or to the extent required by any other applicable rule or regulation, shall delegate administration of the Plan to a Committee. The Committee shall consist solely of two
(2) or more members of the Board each of whom is both an “outside director,” within the meaning of Section 162(m) of the Code, and a “non-employee director,” as defined in Rule 16b-3(b)(3) of the Exchange Act, or any
successor definition adopted by the Board. Notwithstanding the foregoing: (a) the full Board, acting by a majority of its members in office, shall conduct the general administration of the Plan with respect to all Awards granted to Independent
Directors and for purposes of such Awards the term “Committee” as used in this Plan shall be deemed to refer to the Board and (b) the Committee may delegate its authority hereunder to the extent permitted by Section 12.5.
Appointment of Committee members shall be effective upon acceptance of appointment. The Board may abolish the Committee at any time and revest in the Board the administration of the Plan. Committee members may resign at any time by delivering
written notice to the Board. Vacancies in the Committee may only be filled by the Board. 
 12.2 Action by the Committee. A majority
of the Committee shall constitute a quorum. The acts of a majority of the members present at any meeting at which a quorum is present, and acts approved in writing by a majority of the Committee in lieu of a meeting, shall be deemed the acts of the
Committee. Each member of the Committee is entitled to, in good faith, rely or act upon any report or other information furnished to that member by any officer or other employee of the Company or any Subsidiary, the Company’s independent
certified public accountants, or any executive compensation consultant or other professional retained by the Company to assist in the administration of the Plan. 

12.3 Authority of Committee. Subject to any specific designation in the Plan, the Committee has the exclusive power, authority and
discretion to: 
 (a) Designate Participants to receive Awards; 

  
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 (b) Determine the type or types of Awards to be granted to each Participant; 

(c) Determine the number of Awards to be granted and the number of shares of Stock to which an Award will relate; 

(d) Determine the terms and conditions of any Award granted pursuant to the Plan, including, but not limited to, the exercise price, grant
price, or purchase price, any reload provision, any restrictions or limitations on the Award, any schedule for lapse of forfeiture restrictions or restrictions on the exercisability of an Award, and accelerations or waivers thereof, any provisions
related to non-competition and recapture of gain on an Award, based in each case on such considerations as the Committee in its sole discretion determines; provided, however, that the Committee shall not have the authority to accelerate the
vesting or waive the forfeiture of any Performance-Based Awards; 
 (e) Determine whether, to what extent, and pursuant to what
circumstances an Award may be settled in, or the exercise price of an Award may be paid in, cash, Stock, other Awards, or other property, or an Award may be canceled, forfeited, or surrendered; 

(f) Prescribe the form of each Award Agreement, which need not be identical for each Participant; 

(g) Decide all other matters that must be determined in connection with an Award; 

(h) Establish, adopt, or revise any rules and regulations as it may deem necessary or advisable to administer the Plan; 

(i) Interpret the terms of, and any matter arising pursuant to, the Plan or any Award Agreement; and 

(j) Make all other decisions and determinations that may be required pursuant to the Plan or as the Committee deems necessary or advisable to
administer the Plan. 
 12.4 Decisions Binding. The Committee’s interpretation of the Plan, any Awards granted pursuant to the
Plan, any Award Agreement and all decisions and determinations by the Committee with respect to the Plan are final, binding, and conclusive on all parties. 

12.5 Delegation of Authority. To the extent permitted by applicable law, the Committee may from time to time delegate to a committee of
one or more members of the Board or one or more officers of the Company the authority to grant or amend Awards to Participants other than (a) senior executives of the Company who are subject to Section 16 of the Exchange Act,
(b) Covered Employees, or (c) officers of the Company (or members of the Board) to whom authority to grant or amend Awards has been delegated hereunder. Any delegation hereunder shall be subject to the restrictions and limits that the
Committee specifies at the time of such delegation, and the Committee may at any time rescind the authority so delegated or appoint a new delegatee. At all times, the delegatee appointed under this Section 12.5 shall serve in such capacity at
the pleasure of the Committee. 

  
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 ARTICLE 13 

EFFECTIVE AND EXPIRATION DATE 

13.1 Effective Date. The Plan is effective as of the date the Plan is approved by the Company’s stockholders (the
“Effective Date”). The Plan will be deemed to be approved by the stockholders if it receives the affirmative vote or written consent of the holders of a majority of the shares of stock of the Company present or represented and
entitled to vote at a meeting duly held in accordance with the applicable provisions of the Company’s Bylaw. 
 13.2 Expiration
Date. The Plan will expire on, and no Incentive Stock Option or other Award may be granted pursuant to the Plan after, the earlier of the tenth anniversary of (i) the Effective Date or (ii) the date this Plan is approved by the Board.
Any Awards that are outstanding on the tenth anniversary of the Effective Date shall remain in force according to the terms of the Plan and the applicable Award Agreement. 

ARTICLE 14 

AMENDMENT, MODIFICATION, AND TERMINATION 

14.1 Amendment, Modification, and Termination. With the approval of the Board, at any time and from time to time, the Committee may
terminate, amend or modify the Plan; provided, however, that (a) to the extent necessary and desirable to comply with any applicable law, regulation, or stock exchange rule, the Company shall obtain stockholder approval of any Plan
amendment in such a manner and to such a degree as required, and (b) stockholder approval is required for any amendment to the Plan that increases the number of shares available under the Plan (other than any adjustment as provided by Article
11). Notwithstanding any provision in this Plan to the contrary, absent approval of the stockholders of the Company, no Option may be amended to reduce the per share exercise price of the shares subject to such Option below the per share exercise
price as of the date the Option is granted and, except as permitted by Article 11, no Option may be granted in exchange for, or in connection with, the cancellation or surrender of an Option having a higher per share exercise price. 

14.2 Awards Previously Granted. Except as otherwise provided in Section 15.13 below, no termination, amendment, or modification of
the Plan shall adversely affect in any material way any Award previously granted pursuant to the Plan without the prior written consent of the Participant. 

ARTICLE 15 
 GENERAL
PROVISIONS 
 15.1 No Rights to Awards. No Eligible Individual or other person shall have any claim to be granted any Award
pursuant to the Plan, and neither the Company nor the Committee is obligated to treat Eligible Individuals, Participants or any other persons uniformly. 

  
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 15.2 No Stockholders Rights. Except as otherwise provided herein, a Participant shall have
none of the rights of a stockholder with respect to shares of Stock covered by any Award until the Participant becomes the record owner of such shares of Stock. 

15.3 Withholding. The Company or any Subsidiary shall have the authority and the right to deduct or withhold, or require a Participant
to remit to the Company, an amount sufficient to satisfy federal, state, local and foreign taxes (including the Participant’s FICA obligation) required by law to be withheld with respect to any taxable event concerning a Participant arising as
a result of this Plan. The Committee may in its discretion and in satisfaction of the foregoing requirement allow a Participant to elect to have the Company withhold shares of Stock otherwise issuable under an Award (or allow the return of shares of
Stock) having a Fair Market Value equal to the sums required to be withheld. 
 Notwithstanding any other provision of the Plan, the number
of shares of Stock which may be withheld with respect to the issuance, vesting, exercise or payment of any Award (or which may be repurchased from the Participant of such Award within six (6) months (or such other period as may be determined by
the Committee) after such shares of Stock were acquired by the Participant from the Company) in order to satisfy the Participant’s federal, state, local and foreign income and payroll tax liabilities with respect to the issuance, vesting,
exercise or payment of the Award shall be limited to the number of shares which have a Fair Market Value on the date of withholding or repurchase equal to the aggregate amount of such liabilities based on the minimum statutory withholding rates for
federal, state, local and foreign income tax and payroll tax purposes that are applicable to such supplemental taxable income. 
 15.4 No
Right to Employment or Services. Nothing in the Plan or any Award Agreement shall interfere with or limit in any way the right of the Company or any Subsidiary to terminate any Participant’s employment or services at any time, nor confer
upon any Participant any right to continue in the employ or service of the Company or any Subsidiary. 
 15.5 Unfunded Status of
Awards. The Plan is intended to be an “unfunded” plan for incentive compensation. With respect to any payments not yet made to a Participant pursuant to an Award, nothing contained in the Plan or any Award Agreement shall give the
Participant any rights that are greater than those of a general creditor of the Company or any Subsidiary. 
 15.6 Indemnification.
To the extent allowable pursuant to applicable law, each member of the Committee or of the Board shall be indemnified and held harmless by the Company from any loss, cost, liability, or expense that may be imposed upon or reasonably incurred by such
member in connection with or resulting from any claim, action, suit, or proceeding to which he or she may be a party or in which he or she may be involved by reason of any action or failure to act pursuant to the Plan and against and from any and
all amounts paid by him or her in satisfaction of judgment in such action, suit, or proceeding against him or her; provided he or she gives the Company an opportunity, at its own expense, to handle and defend the same before he or she undertakes to
handle and defend it on his or her own behalf. The foregoing right of indemnification shall not be exclusive of any other rights of indemnification to which such persons may be entitled pursuant to the Company’s Certificate of Incorporation or
Bylaws, as a matter of law, or otherwise, or any power that the Company may have to indemnify them or hold them harmless. 

  
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 15.7 Relationship to other Benefits. No payment pursuant to the Plan shall be taken into
account in determining any benefits pursuant to any pension, retirement, savings, profit sharing, group insurance, welfare or other benefit plan of the Company or any Subsidiary except to the extent otherwise expressly provided in writing in such
other plan or an agreement thereunder. 
 15.8 Expenses. The expenses of administering the Plan shall be borne by the Company and its
Subsidiaries. 
 15.9 Titles and Headings. The titles and headings of the Sections in the Plan are for convenience of reference only
and, in the event of any conflict, the text of the Plan, rather than such titles or headings, shall control. 
 15.10 Fractional
Shares. No fractional shares of Stock shall be issued and the Committee shall determine, in its discretion, whether cash shall be given in lieu of fractional shares or whether such fractional shares shall be eliminated by rounding up or down as
appropriate. 
 15.11 Limitations Applicable to Section 16 Persons. Notwithstanding any other provision of the Plan, the Plan,
and any Award granted or awarded to any Participant who is then subject to Section 16 of the Exchange Act, shall be subject to any additional limitations set forth in any applicable exemptive rule under Section 16 of the Exchange Act
(including any amendment to Rule 16b-3 of the Exchange Act) that are requirements for the application of such exemptive rule. To the extent permitted by applicable law, the Plan and Awards granted or awarded hereunder shall be deemed amended to the
extent necessary to conform to such applicable exemptive rule. 
 15.12 Government and Other Regulations. The obligation of the
Company to make payment of awards in Stock or otherwise shall be subject to all applicable laws, regulations, rules and requirements, and to such approvals by government agencies as may be required. The Company shall be under no obligation to
register pursuant to the Securities Act, or to qualify pursuant to any state securities laws, any of the shares of Stock issued pursuant to the Plan. If the shares issued pursuant to the Plan may in certain circumstances be exempt from registration
pursuant to the Securities Act, the Company may restrict the transfer of such shares in such manner as it deems advisable to ensure the availability of any such exemption and in addition may require that a Participant make such reasonable covenants,
agreements and representations as the Board or the Committee deems advisable in order to comply with any such laws, regulations, rules or requirements. The Company may, in its discretion, defer the effectiveness of an exercise of an Option hereunder
or the issuance or transfer of Stock pursuant to any Award to ensure compliance with federal or state securities laws; provided that the Company shall take any commercially reasonable steps to reduce or eliminate any restrictions requiring
such a period of deferral (it being understood that this proviso shall in no event obligate the Company to file a registration statement). The Company shall inform the Participant in writing of its decision to defer the effectiveness of the exercise
of an Option or the issuance and transfer of Stock pursuant to any Award. During the period that the effectiveness of the exercise of an Option has been deferred, the Participant may by written notice, withdraw such exercise and obtain the refund of
any amount paid with respect thereto. 

  
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 15.13 Section 409A. (a) To the extent that the Committee determines that any
Award granted under the Plan is subject to Section 409A of the Code, the Award Agreement evidencing such Award shall incorporate the terms and conditions required by Section 409A of the Code. To the extent applicable, the Plan and Award
Agreements shall be interpreted in accordance with Section 409A of the Code and Department of Treasury regulations and other interpretive guidance issued thereunder, including without limitation any such regulations or other guidance that may
be issued after the Effective Date. Notwithstanding anything to the contrary in Section 14.2 or any other provision of the Plan, in the event that following the Effective Date the Committee determines that any Award may be subject to
Section 409A of the Code and related Department of Treasury guidance (including such Department of Treasury guidance as may be issued after the Effective Date), the Committee may adopt such amendments to the Plan and the applicable Award
Agreement or adopt other policies and procedures (including amendments, policies and procedures with retroactive effect), or take any other actions, that the Committee determines are necessary or appropriate to (i) exempt the Award from
Section 409A of the Code and/or preserve the intended tax treatment of the benefits provided with respect to the Award, or (ii) comply with the requirements of Section 409A of the Code and related Department of Treasury guidance. If
the Committee reasonably determines that, under Section 409A of the Code, payments with respect to any Award may not be made at the time contemplated by the terms of the Plan or the relevant Award Agreement without causing the Participant
holding such Award to be subject to taxation under 409A of the Code, the Company may make such payment on the first day that would not result in the Participant incurring any tax liability under Section 409A of the Code. 

15.14 Governing Law. The Plan and all Award Agreements shall be construed in accordance with and governed by the laws of the State of
Delaware. 
 * * * * * 

  
 23 

 AMENDMENT NO. 1 

TO 
 APELLIS
PHARMACEUTICALS, INC. 
 2010 EQUITY INCENTIVE PLAN 

The Apellis Pharmaceuticals, Inc. 2010 Equity Incentive Plan (the “Plan”) be and hereby is amended by deleting Section 3.1(a)
thereof and substituting in lieu thereof the following: 
 (a) Subject to Article 11 and Section 3.1(b), the maximum
aggregate number of shares of Stock which may be issued or transferred pursuant to Awards under the Plan shall be 5,200,000 shares. 

Except as set forth above, the remainder of the Plan remains in full force and effect. 

 

			
		  	Adopted by the Board of Directors
		  	on July 19, 2013
		
		  	Adopted by the Stockholders
		  	on July 22, 2013

 AMENDMENT NO. 2 

TO 
 APELLIS
PHARMACEUTICALS, INC. 
 2010 EQUITY INCENTIVE PLAN 

The Apellis Pharmaceuticals, Inc. 2010 Equity Incentive Plan, as amended (the “Plan”) be and hereby is amended by deleting
Section 3.1(a) thereof and substituting in lieu thereof the following: 
 (a) Subject to Article 11 and
Section 3.1(b), the maximum aggregate number of shares of Stock which may be issued or transferred pursuant to Awards under the Plan shall be 7,200,000 shares. 

Except as set forth above, the remainder of the Plan remains in full force and effect. 

 

			
		  	Adopted by the Board of Directors
		  	on November 24, 2014
		
		  	Adopted by the Stockholders
		  	on November 24, 2014

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