Document:

<PAGE>

                                                                    Exhibit 10.4

                       SECOND AMENDMENT TO EXTEND LEASE
                       DATED NOVEMBER 23, 1994 ("LEASE")
                         BY AND BETWEEN BRUCE K. HOYT
                          AND GEERLINGS & WADE, INC.

Whereas the Lease of November 23, 1994 by and between Bruce K. Hoyt (the
"Lessor") and Geerlings & Wade, Inc. (the "Lessee") has an expiration of
February 28, 1998 (the "Lease") and the First Amendment to the Lease of March
18, 1998 has an expiration of February 28, 2001 and;

Whereas Lessor and Lessee desire to extend the term of this Lease for an
additional fifteen (15) months.

Now, therefore, in consideration of rents reserved and of the covenants and
agreements herein set forth, it is agreed that the Lease be hereby amended from
and after the date hereof as follows:

     1.   The Lease shall terminate on May 31, 2002.

     2.   Lessee shall pay to Lessor as Base Rent:

             Months 1 - 15 (March, 2001 thru May, 2002)  $1,750.00

     3.   Paragraph 11.1(1) shall be replaced with "Tenant shall fail to pay
          when due any installment of rent or any other payment pursuant to this
          Lease and the failure is not cured within five (5) days after written
          notice to Tenant."

     4.   In the third sentence of Paragraph 14.5 replace "...shall be deemed
          delivered (whether or not actually received) when deposited in" with
          "...shall be deemed delivered when received by the person to whom the
          notice is addressed and sent via."

     5.   In paragraph 14.7 strike the word "personally" and the sentence "In
          the event any representation or warranty is false, all persons who
          execute this Lease shall be liable, individually, as Tenant."

     6.   Lessee shall have the right to renew this Lease for a period of
          thirty-six (36) months.  Tenant shall notify Lessor ninety (90) days
          prior to the expiration of this Lease Amendment if they are not
          exercising this option.  The rental rate for this renewal period will
          be:

             a.  Months 1-12 (June, 2002 thru May, 2003) $1,750.00
             b.  Months 13-24 (June, 2003 thru May, 2004) $1,800.00
             c.  Months 25-36 (June, 2004 thru May, 2005) $1,850.00

     7.   All other terms and conditions of the Lease dated November 23, 1994
          shall remain unchanged.
<PAGE>

     Agreed and acknowledged the 28th day of February, 2001:

LESSEE:                                 LESSOR:

Geerlings & Wade, Inc.                  Bruce K. Hoyt Company

By: /s/ David R. Pearce                 By: /s/ Bruce K. Hoyt
    -------------------                     -----------------
David R. Pearce, President              Bruce K. Hoyt, Owner
(Print Name and Title)

                                      -2-<PAGE>

                                                                    Exhibit 10.5

                              MEHLAND DEVELOPERS
                           521 BYERS ROAD, SUITE 201
              MIAMISBURG, OHIO 45342   937/866-1974  FAX 866-2952

                               ADDENDUM TO LEASE

                              SECOND TERM RENEWAL

                               OCTOBER 23, 2000

BETWEEN:        Lessor - Mehland Developers
                Lessee - Geerlings & Wade

LEASE DATED:    October 31, 1994

SECTION:        5.  OPTIONS TO RENEW:

                The Lease shall be renewed for one additional term of three (3)
                years, commencing on March 2, 2001 through February 28, 2004.

SECTION:        6.  RENEWAL TERM RENT:

                Rent for the second renewal term shall be increased yearly based
                on the CPI.

All other conditions of the Lease shall remain in effect.

LESSEE:                                 LESSOR:

GEERLINGS & WADE                        MEHLAND DEVELOPERS
960 Turnpike Street                     521 Byers Road, Suite 201
Canton, MA 02021                        Miamisburg, OH 45342

BY: /s/ David R. Pearce, President      BY: /s/ M. Metzger
    ------------------------------          --------------

DATE: 11/7/00                           DATE: 10/23/00
      -------                                 --------<PAGE>

                                  EXHIBIT 10.1

                                 LEASE AGREEMENT

             LANDLORD:         BOYER RESEARCH PARK ASSOCIATES VI,
                               BY ITS GENERAL PARTNER, THE BOYER
                               COMPANY, L.C.

             TENANT:           MYRIAD GENETICS, INC.
                               PHASE III
<PAGE>

                                TABLE OF CONTENTS
                                -----------------

<TABLE>
<CAPTION>
DESCRIPTION                                                                                               PAGE
-----------                                                                                               ----
<S>                                                                                                       <C>
I.       PREMISES                                                                                            1
         1.1      Description of Premises                                                                    1
         1.2      Work of Improvement                                                                        1
         1.3      Construction of Shell Building                                                             2
         1.4      Construction of Leased Premises                                                            2

II.      TERM                                                                                                2
         2.1      Length of Term                                                                             2
         2.2      Commencement Date; Obligation to Pay Rent                                                  2
         2.3      Renewal Option                                                                             3
         2.4      Acknowledgment of Commencement Date                                                        3

III.     BASIC RENTAL PAYMENTS                                                                               3
         3.1      Basic Annual Rent                                                                          3
         3.2      Additional Monetary Obligations                                                            4

IV.      ADDITIONAL RENT                                                                                     4
         4.1      Basic Annual Rent.                                                                         4
         4.2      Report of Basic Costs and Statement of Estimated Costs                                     5
         4.3      Payment of Additional Rent                                                                 6
         4.4      Resolution of Disagreement                                                                 6
         4.5      Limitations                                                                                7

V.       SECURITY DEPOSIT                                                                                    7

VI.      USE                                                                                                 7
         6.1      Use of Leased Premises                                                                     7
         6.2      Prohibition of Certain Activities or Uses                                                  7
         6.3      Affirmative Obligations with Respect to Use                                                8
         6.4      Suitability                                                                                8
         6.5      Taxes                                                                                      8

VII.     UTILITIES AND SERVICE                                                                               8
         7.1      Obligation of Landlord                                                                     9
         7.2      Tenant's Obligations                                                                       9
         7.3      Additional Limitations                                                                     9
         7.4      Limitation on Landlord's Liability                                                        10
</TABLE>

                                       i
<PAGE>

<TABLE>
<CAPTION>
DESCRIPTION                                                                                                PAGE
-----------                                                                                                ----
<S>                                                                                                         <C>
VIII.    MAINTENANCE AND REPAIRS; ALTERATIONS; ACCESS                                                       10
         8.1      Maintenance and Repairs by Landlord                                                       10
         8.2      Maintenance and Repairs by Tenant                                                         10
         8.3      Tenant Approval of Management and Maintenance Services                                    10
         8.4      Alterations                                                                               11
         8.5      Landlord's Access to Leased Premises                                                      11

IX.      ASSIGNMENT                                                                                         12
         9.1      Assignment Prohibited                                                                     12
         9.2      Consent Required                                                                          12
         9.3      Landlord's Right in Event of Assignment                                                   12
         9.4      Tenant's Right to Assign                                                                  13

X.       INDEMNITY                                                                                          14
         10.1     Indemnification                                                                           14
         10.2     Release of Landlord                                                                       14
         10.3     Notice                                                                                    14
         10.4     Litigation                                                                                14

XI.      INSURANCE                                                                                          14
         11.1     Fire and                                                                                  14
         11.2     Liability Insurance                                                                       14
         11.3     Property Coverage                                                                         15
         11.4     Subrogation                                                                               15
         11.5     Lender                                                                                    15

XII.     DESTRUCTION                                                                                        15

XIII.    CONDEMNATION                                                                                       16
         13.1     Total Condemnation                                                                        16
         13.2     Partial Condemnation                                                                      16
         13.3     Landlord's Option to Terminate                                                            16
         13.4     Award                                                                                     16
         13.5     Definition                                                                                16

XIV.     LANDLORD'S RIGHTS TO CURE                                                                          17
         14.1     General Right                                                                             17
         14.2     Mechanic's Lien                                                                           17

XV.      FINANCING; SUBORDINATION                                                                           17
         15.1     Subordination                                                                             17
         15.2     Attornment                                                                                18
         15.3     Financial Information                                                                     18
</TABLE>

                                      ii
<PAGE>

<TABLE>
<CAPTION>
DESCRIPTION                                                                                                PAGE
-----------                                                                                                ----
<S>                                                                                                        <C>
XVI.     EVENTS OF DEFAULT; REMEDIES OF LANDLORD                                                            18
         16.1     Default by Tenant                                                                         18
         16.2     Remedies                                                                                  19
         16.3     Past Due Sums; Penalty                                                                    19

XVII.    PROVISIONS APPLICABLE AT TERMINATION OF LEASE                                                      19
         17.1     Surrender of Premises                                                                     19
         17.2     Holding Over                                                                              20

XVIII.   ATTORNEYS' FEES                                                                                    20

XIX.     ESTOPPEL CERTIFICATE                                                                               20
         19.1     Landlord's Right to Estoppel Certificate                                                  20
         19.2     Effect of Failure to Provide Estoppel Certificate                                         20

XX.      PARKING                                                                                            21

XXI.     SIGNS, AWNINGS, AND CANOPIES                                                                       21

XXII.    MISCELLANEOUS PROVISIONS                                                                           21
         22.1     No Partnership                                                                            21
         22.2     Force Majeure                                                                             21
         22.3     No Waiver                                                                                 21
         22.4     Notice                                                                                    21
         22.5     Captions; Attachments; Defined Terms                                                      22
         22.6     Recording                                                                                 22
         22.7     Partial Invalidity                                                                        22
         22.8     Broker's Commissions                                                                      23
         22.9     Tenant Defined:  Use of Pronouns                                                          23
         22.10    Provisions Binding, Etc.                                                                  23
         22.11    Entire Agreement, Etc.                                                                    23
         22.12    Governing Law                                                                             24
</TABLE>

                                      iii
<PAGE>

<TABLE>
<CAPTION>
DESCRIPTION                                                     PAGE
-----------                                                     ----
<S>                                                             <C>
SIGNATURES                                                       24
NOTARIES                                                         25
</TABLE>

RIDER             Yes   X   No _____
                      -----
GUARANTY          Yes _____ No   X
                               -----

EXHIBIT "A"    DESCRIPTION OF REAL PROPERTY
EXHIBIT "B"    PLANS AND SPECIFICATIONS OF BUILDING
EXHIBIT "C"    WORK LETTER-CONSTRUCTION AND/OR FINISH OF IMPROVEMENTS TO LEASED
               PREMISES
EXHIBIT "D"    ACKNOWLEDGMENT OF COMMENCEMENT DATE & ESTOPPEL CERTIFICATE
EXHIBIT "E"    COST TO CONSTRUCT LEASED PREMISES
EXHIBIT "F"    IMPROVEMENT REMOVAL AGREEMENT

                                      iv
<PAGE>

                                 LEASE AGREEMENT

                       RESEARCH PARK BUILDING - PHASE III

         THIS LEASE AGREEMENT (the "Lease") is made and entered into as of this
31st day of March, 2001 by and between BOYER RESEARCH PARK ASSOCIATES VI, BY ITS
GENERAL PARTNER, THE BOYER COMPANY, L.C. (the "Landlord"), and MYRIAD GENETICS,
INC. (the "Tenant").

         For and in consideration of the rental to be paid by tenant and of the
covenants and agreements herein set forth to be kept and performed by Tenant,
Landlord hereby leases to Tenant and Tenant hereby leases from Landlord, the
Leased Premises (as hereafter defined), at the rental and subject to and upon
all of the terms, covenants and agreements hereinafter set forth.

    I.   PREMISES

               1.1   Description of Premises. Landlord does hereby demise, lease
         and let unto Tenant, and Tenant does hereby take and receive from
         Landlord the following:

               (a)   That certain floor area containing approximately 57,243
         gross rentable square feet (the "Leased Premises"), more particularly,
         19,555 gross rentable square feet on Floor One, 19,318 gross rentable
         square feet on Floor Two, and 18,370 gross rentable square feet on the
         Floor Three in the three story office building (the "Building") located
         at approximately 320 Wakara Way in Salt Lake City, Utah, on the real
         property (the "Property") described on Exhibit "A" attached hereto and
         by this reference incorporated herein. The Building to be constructed
         is described on the Plans and Specifications attached as Exhibit "B."

               (b)   Such non-exclusive rights-of-way, easements and similar
         rights with respect to the Building and Property as may be reasonably
         necessary for access to and egress from, the Leased Premises.

               (c)   The exclusive right to use One Hundred Sixty (160)
         designated stalls in the parking structure under the building for which
         Tenant shall pay Landlord the sum of $21,675.00 per month and shall be
         subject to annual adjustments as specified in Section 1.3 of the Lease.

               1.2   Work of Improvement. The obligation of Landlord and Tenant
         to perform the work and supply the necessary materials and labor to
         prepare the Leased Premises for occupancy are described in detail on
         Exhibit "C". Landlord and Tenant shall expend all funds and do all acts
         required of them as described on Exhibit "C" and shall perform or

                                       1
<PAGE>

         have the work performed promptly and diligently in a first class and
         workmanlike manner.

               1.3   Construction of Shell Building. Landlord shall, at its own
         cost and expense, construct and complete a three story 57,243 gross
         rentable square foot building and cause all of the construction which
         is to be performed by it in completing the Building and performing its
         work (including the Tenant Finish work) as set forth on Exhibit "C", to
         be substantially completed as evidenced by a Certificate of Occupancy,
         and the Leased Premises ready for Tenant's occupancy as soon as
         reasonably possible, but in no event later than July 1, 2002 ("Target
         Date"). In the event that Landlord's construction of obligation has not
         been fulfilled upon the expiration of the "Target Date", Tenant shall
         have the right to exercise any right or remedy available to it under
         this Lease, including the right to terminate this Lease and the right
         to charge Landlord and cause Landlord to pay any increased costs
         associated with Tenant's current leases due to holding over in such
         space or moving to temporary space; provided that under no
         circumstances shall Landlord be liable to Tenant resulting from delay
         in construction covered by circumstances beyond Landlord's direct
         control.

               1.4   Construction of Leased Premises. Upon completion of Tenant
         Finish plans as contemplated by Exhibit "C," Landlord shall provide a
         budget for Tenant's approval prior to the commencement of construction
         of the Leased Premises (see Exhibit "E"). Landlord shall itemize each
         part of the construction and its associated estimated cost. Tenant
         shall be obligated for all costs shown on Exhibit "E". Upon acceptance
         by Tenant of the budget, Landlord shall construct in accordance with
         Exhibit "C" all items pertaining to the Tenant Finish, including the
         obligation to pay for all cost changes not initiated by Tenant.

  II.    TERM

               2.1   Length of Term. The term of this Lease shall be for a
         period of fifteen (15) years plus the partial calendar month, if any,
         occurring after the Commencement Date (as hereinafter defined) if the
         Commencement Date occurs other than on the first day of a calendar
         month.

               2.2   Commencement Date; Obligation to Pay Rent. The term of this
         Lease and Tenant's obligation to pay rent hereunder shall commence on
         the first to occur of the following dates ("Commencement Date"):

               (a)   The date Tenant occupies the Premises and conducts
         business.

               (b)   The date fifteen (15) days after the Landlord, or
         Landlord's supervising contractor, notified Tenant in writing that
         Landlord's construction obligations respecting the Leased Premises have
         been fulfilled and/or that the Leased Premises are ready for

                                       2
<PAGE>

         occupancy and/or performance of Tenant's work. Such notice shall be
         accompanied by an occupancy permit and a certificate from the Building
         Architect stating that remaining punch list items can be completed
         within fifteen (15) days and will not materially interfere with
         Tenant's business. Prior to Commencement Date, it is contemplated that
         Tenant shall be able to perform its construction obligation as per
         Exhibit C II(H).

               2.3   Renewal Option. If this Lease then remains in full force
         and effect, Tenant shall have the option to renew this Lease for two
         five (5) year options commencing on the expiration date. Each option
         must be exercised by written notice to Landlord one hundred and eighty
         (180) days from the expiration of the previous term and once exercised
         is irrevocable. Base rent during each renewal term shall be mutually
         agreed upon between Landlord and Tenant within Sixty (60) days after
         Tenant has exercised the respective renewal option.

               2.4   Acknowledgment of Commencement Date. Landlord and Tenant
         shall execute a written acknowledgment of the commencement Date in the
         form attached hereto as Exhibit "D".

 III.    BASIC RENTAL PAYMENTS

               3.1   Basic Annual Rent. Tenant agrees to pay to Landlord as
         basic annual rent (the "Basic Annual Rent") at such place as Landlord
         may designate, without prior demand therefore and without any deduction
         or set off whatsoever, the sum of Nine Hundred Eighty Six Thousand
         Seven Hundred Six and no/100 Dollars ($986,706.00). Said Basic Annual
         Rent shall be due and payable in twelve (12) equal monthly installments
         to be paid in advance on or before the first day of each calendar month
         during the term of the Lease. Basic Annual Rent shall escalate at the
         beginning of the fourth year and every three (3) years thereafter using
         either a 3% annually compounded rate or the change in the All Urban
         Index, whichever is less (each such anniversary being referred to as an
         "adjustment date"). For purposes of this Lease the term "All Urban
         Index" shall mean the Consumer Price Index for All Urban Consumers-U.S.
         City Average-all Items (1982-1984 equals 100 base) as published by the
         United States Bureau of Labor Statistics or any successor agency or any
         other index hereinafter employed by the Bureau of Labor Statistics in
         lieu of said index. The price index for the third month preceding the
         month in which the Lease commences shall be considered the Basic Price
         Index. Therefore, the beginning of the fourth year and every three
         years thereafter, the Basic Annual Rent set forth in this Section 3.1
         shall be adjusted by multiplying such rental by a fraction, the
         numerator of which is the Price Index for the third month preceding the
         beginning of the anniversary (or each such adjustment date) and the
         denominator of which is the Basic Price Index.

               In no event shall Basic Annual Rent be reduced. In the event the
         Commencement Date occurs on a day other than the first day of a
         calendar month, then rent shall be paid

                                       3
<PAGE>

         on the Commencement Date for the initial fractional calendar month
         prorated on a per-diem basis (based upon a thirty (30) day month).

               3.2   Additional Monetary Obligations. Tenant shall also pay as
         rental (in addition to the Basic Annual Rent) all other sums of money
         as shall become due and payable by Tenant to Landlord under this Lease.
         Landlord shall have the same remedies in the case of a default in the
         payment of said other sums of money as are available to Landlord in the
         case of a default in the payment of one or more installments of Basic
         Annual Rent.

 IV.     ADDITIONAL RENT

               4.1   Basic Annual Rent. It is the intent of both parties that
         the Basic Annual Rent herein specified shall be absolutely net to the
         Landlord throughout the term of this Lease, and that all costs,
         expenses and obligations relating to Tenant's pro-rata share of the
         Building, Property and/or Building, Property and/or Leased Premises
         which may arise or become due during the term shall be paid by Tenant
         in the manner hereafter provided.

               For purposes of this Part IV and the Lease in general, the
         following words and phrases shall have the meanings set forth below:

               (a)   "Basic Costs" shall mean all actual costs and expenses
         incurred by Landlord in connection with the ownership, operation,
         management and maintenance of the Building and Property and related
         improvements located thereon (the "Improvements"), including, but not
         limited to, all expenses incurred by Landlord as a result of Landlord's
         compliance with any and all of its obligations under this Lease other
         than the performance by Landlord of its work under Sections 1.2, 1.3
         and 1.4 of this Lease or similar provisions of leases with other
         tenants. In explanation of the foregoing, and not in limitation
         thereof, Basic Costs shall include: all real and personal property
         taxes and assessments (whether general or special, known or unknown,
         foreseen or unforeseen) and any tax or assessment levied or charged in
         lieu thereof, whether assessed against Landlord and/or Tenant and
         whether collected from Landlord and/or Tenant; snow removal, trash
         removal, supplies, insurance, license, permit and inspection fees, cost
         of services of independent contractors, cost of compensation (including
         employment taxes and fringe benefits) of all persons who perform
         regular and recurring duties connected with day-to-day operation,
         maintenance, repair, and replacement of the Building, its equipment and
         the adjacent walk, and landscaped area (including, but not limited to
         janitorial, scavenger, gardening, security, parking, elevator,
         painting, plumbing, electrical, mechanical, carpentry, window washing,
         structural and roof repairs and reserves (Landlord may collect up to
         one percent (1%) of total Basic Costs as a contribution toward
         reserves), signing and advertising, and rental expense or a reasonable
         allowance for depreciation of personal property

                                       4
<PAGE>

         used in the maintenance, operation and repair of the Building. Basic
         Costs shall not include expenses incurred in connection with leasing,
         renovating, or improving space for tenant, expenses incurred for
         repairs resulting from damage by fire, windstorm or other casualty, to
         the extent such repairs are paid for by insurance proceeds, expenses
         paid by any tenant directly to third parties, or as to which Landlord
         is otherwise reimbursed by any third party or Tenant; expenses which,
         by generally accepted accounting principles, are treated as capital
         items except that if, as a result of governmental requirements, laws or
         regulations, Landlord shall expend monies directly or indirectly for
         improvements, additions or alterations to the Building which, by
         generally accepted accounting principles, are treated as a capital
         expenditures, the amortization of such capital expenditures based on a
         life acceptable to the appropriate taxing authority together with
         interest at the rate of 9% per annum shall be considered Basic Costs.
         The foregoing notwithstanding, Basic Costs shall not include
         depreciation on the Building and Tenant Finish; amounts paid toward
         principal or interest of loans of Landlord; nor shall Basic Costs
         include "Direct Costs" as defined in Section 4.1(b) below.

               (b)   "Direct Costs" shall mean all actual costs and expense
         incurred by Landlord in connection with the operation, management,
         maintenance, replacement, and repair of tenants' premises, including
         but not limited to janitorial services (if Landlord is responsible to
         provide this service), maintenance, repairs, supplies, utilities,
         heating, ventilation, air conditioning, and property management fees,
         which property management fees shall be equal to a percentage of
         Tenant's Basic Annual Rent and Estimated Costs including electricity,
         which percentage shall not exceed four percent (4%) of the sum of Basic
         Annual Rent, Estimated Costs and cost of electricity for the Leased
         Premises.

               (c)   "Estimated Costs" shall mean the projected amount of
         Tenant's Direct Costs and Basic Costs, excluding the costs of
         electricity provided to Tenant's Leased Premises. The Estimated Costs
         for the calendar year in which the Lease commences are $256,968, and
         are not included in the Basic Annual Rent. If the Estimated Costs as of
         the date Tenant takes occupancy are greater than Tenant's Estimated
         Costs at the time this Lease is executed, the Estimated Costs shall be
         increased to equal the Estimated Costs as of the date of Tenant's
         occupancy.

               (d)   "Tenant's Proportionate Share of Basic Costs" shall mean
         the percentage derived from the fraction, the numerator of which is the
         gross rentable square footage of the Lease premises (57,243), the
         denominator of which is the gross rentable square footage of the
         building (57,243). In this Lease, Tenant's Proportionate Share of
         Basic Costs shall be 100% of the Basic Costs for the Leased Premises.

               4.2   Report of Basic Costs and Statement of Estimated Costs.

                                       5
<PAGE>

               (a)   After the expiration of each calendar year occurring during
         the term of this Lease, Landlord shall furnish Tenant a written
         statement of Tenant's Proportionate Share of Basic Costs (Section
         4.1(d)) and the Tenant's Direct Costs occurring during the previous
         calendar year. The written statement shall specify the amount by which
         Tenant's Direct Costs and Basic Costs exceed or are less than the
         amounts paid by Tenant during the previous calendar year pursuant to
         Section 4.3(b) below.

               (b)   At the same time specified in Section 4.2(a) above,
         Landlord shall furnish Tenant a written statement of the Estimated
         Costs for the then current calendar year.

               4.3   Payment of Additional Rent. Tenant shall pay as additional
         rent ("Additional Rent") Tenant's Direct Costs and Tenant's
         Proportionate Share of Basic Costs. The Additional Rent shall be paid
         as follows:

               (a)   With each monthly payment of Basic Annual Rent due pursuant
         to Section 3.1 above, Tenant shall pay to Landlord, without offset or
         deduction, one-twelfth (l/12th) of the Estimated Costs as defined in
         Section 4.1(c).

               (b)   Within thirty (30) days after delivery of the written
         statement referred to in section 4.2(a) above, Tenant shall pay to
         Landlord the amount by which Tenant's Direct Costs and Basic Costs, as
         specified in such written statements, exceed and aggregate of Estimated
         Costs actually paid by Tenant for the year at issue. Tenant shall have
         the right to audit Landlord's books upon reasonable notice. Tenant
         shall pay costs associated with the audit unless Tenant finds that
         Landlord has inflated expenses by more than ten percent (10%), in which
         case, Landlord will pay audit charges. Payments by Tenant shall be made
         pursuant to this Section 4.3(b) notwithstanding that a statement
         pursuant to Section 4.2(a) is furnished to Tenant after the expiration
         of the term of this Lease.

               (c)   If the annual statement of costs indicates that the
         Estimated Costs paid by Tenant pursuant to subsection (b) above for any
         year exceeded Tenant's actual Direct Costs and Basic Costs for the same
         year, Landlord, at its election, shall either (i) promptly pay the
         amount of such excess to Tenant, or (ii) apply such excess against the
         next installment of Basic Annual Rental or Additional Rent due
         hereunder.

               4.4   Resolution of Disagreement. Every statement given by
         Landlord pursuant to Section 4.2 shall be conclusive and binding upon
         Tenant unless within sixty (60) days after the receipt of such
         statement Tenant shall notify Landlord that it disputes the correctness
         thereof, specifying the particular respects in which the statement is
         claimed to be incorrect. If such dispute shall not have been settled by
         agreement, the parties hereto

                                       6
<PAGE>

     shall submit the dispute to arbitration within ninety (90) days after
     Tenant's receipt of statement.  Pending the determination of such dispute
     by agreement or arbitration as aforesaid, Tenant shall, within thirty (30)
     days after receipt of such statement, pay Additional Rent in accordance
     with Landlord's statement, and such payment shall be without prejudice to
     Tenant's position.  If the dispute shall be determined in Tenant's favor,
     Landlord shall forthwith pay Tenant the amount of Tenant's overpayment of
     rents resulting from compliance with Landlord's statement, including
     interest on disputed amounts at prime plus two percent (2%).  Landlord
     agrees to grant Tenant reasonable access to Landlord's books and records
     for the purpose of verifying Basic Costs and Direct Costs for operating
     expenses incurred by Landlord.

          4.5  Limitations.  Nothing contained in this Part IV shall be
     construed at any time so as to reduce the monthly installments of Basic
     Annual Rent payable hereunder below the amount set forth in Section 3.1 of
     this Lease.

V.   SECURITY DEPOSIT

          Waived

VI.  USE

          6.1  Use of Leased Premises.  The Leased Premises shall be used and
     occupied by Tenant for laboratory and general office purposes only and for
     no other purpose whatsoever without the prior written consent of Landlord.

          6.2  Prohibition of Certain Activities or Uses.  The Tenant shall not
     do or permit anything to be done in or about, or bring or keep anything in
     the Leased Premises which is prohibited by this Lease or will, in any way
     or to any extent:

          (a)  Adversely affect any fire, liability or other insurance policy
     carried with respect to the Building, the Leased Premises or any of the
     contents of the Building (except with Landlord's express written
     permission, which will not be unreasonably withheld, but which may be
     contingent upon Tenant's agreement to bear any additional costs, expenses
     or liability for risk that may be involved).

          (b)  Conflict with or violate any law, statute, ordinance, rule,
     regulation or requirement of any governmental unit, agency or authority
     (whether existing or enacted as promulgated in the future, known or
     unknown, foreseen or unforeseen).

          (c)  Adversely overload the floors or otherwise damage the structural
     soundness of the Leased Premises or Building, or any part thereof (except
     with

                                       7
<PAGE>

     Landlord's express written permission, which will not be unreasonably
     withheld, but which may be contingent upon Tenant's agreement to bear any
     additional costs, expenses or liability for risk that may be involved).

          6.3  Affirmative Obligations with Respect to Use.

          (a)  Tenant will comply with all governmental laws, ordinances,
     regulations, and requirements, now in force or which hereafter may be in
     force, of any lawful governmental body or authorities having jurisdiction
     over the Leased Premises, will keep the Leased Premises and every part
     thereof in a clean, neat, and orderly condition, free of objectionable
     noise, odors, or nuisances, will in all respects and at all times fully
     comply with all applicable health and policy regulations, and will not
     suffer, permit, or commit any waste.

          (b)  At all times during the term hereof, Tenant shall, at Tenant's
     sole cost and expense, comply with all statutes, ordinances, laws, orders,
     rules, regulations and requirements of all applicable federal, state,
     county, municipal and other agencies or authorities, now in effect or which
     may hereafter become effective, which shall impose any duty upon Landlord
     or Tenant with respect to the use, occupation or alterations of the Leased
     Premises (including, without limitation, all applicable requirements of the
     Americans with Disabilities Act of 1990 and all other applicable laws
     relating to people with disabilities, and all rules and regulations which
     may be promulgated thereunder from time to time and whether relating to
     barrier removal, providing auxiliary aids and services or otherwise) and
     upon request of Landlord shall deliver evidence thereof to Landlord.

          6.4  Suitability.  The Leased Premises, Building and Improvements (and
     each and every part thereof) shall be deemed to be in satisfactory
     condition unless, within sixty (60) days after the Commencement Date,
     Tenant shall give Landlord written notice specifying, in reasonable detail,
     the respects in which the Leased Premises, Building or Improvements are not
     in satisfactory condition.  Landlord further provides warranties as
     provided in Exhibit C II paragraphs C and E.

          6.5  Taxes.  Tenant shall pay all taxes, assessments, charges, and
     fees which during the term hereof may be imposed, assessed or levied by any
     governmental or public authority against or upon Tenant's use of the Leased
     Premises or any personal property or fixture kept or installed therein by
     Tenant and on the value of leasehold improvements to the extent that the
     same exceed Building allowances.

VII. UTILITIES AND SERVICE

                                       8
<PAGE>

          7.1  Obligation of Landlord.  During the term of this Lease the
     Landlord agrees to cause to be furnished to the Leased Premises during
     normal operating hours, the following utilities and services, the cost and
     expense of which shall be included in Basic and/or Direct Costs:

          (a)  Electricity, water, gas and sewer service.

          (b)  Telephone connection to the building, but not including telephone
     stations and equipment (it being expressly understood and agreed that
     Tenant shall be responsible for the ordering and installation of telephone
     lines and equipment which pertain to the Leased Premises).

          (c)  Heating and air-conditioning during normal operating hours to
     such extent and to such levels as is reasonably required for the
     comfortable use and occupancy of the Leased Premises subject however to any
     limitations imposed by any government agency.

          (d)  Janitorial service.

          (e)  Security (including the lighting of common halls, stairways,
     entries and restrooms) to such extent as is usual and customary in similar
     buildings in Salt Lake County, Utah.

          (f)  Snow removal service.

          (g)  Landscaping and groundskeeping service.

          (h)  Elevator service.

          (i)  The normal operating hours for office portion of the Leased
     Premises are from 7:00 a.m. to 6:00 p.m., Monday through Friday. Normal
     operating hours for the laboratory portion is 7 a.m. to 11 p.m., Monday
     through Friday.

          7.2  Tenant's Obligations.  Tenant shall arrange for and shall pay the
     entire cost and expense of all telephone stations, equipment and use
     charges, electric light bulbs (but not fluorescent bulbs used in fixtures
     originally installed in the Leased Premises) and all other materials and
     services not expressly required to be provided and paid for pursuant to the
     provisions of Section 7.1 above.

          7.3  Additional Limitations.  If and where heat generating machines
     devices are used in the Leased Premises which affect the temperature
     otherwise maintained by the air conditioning system, Landlord reserves the
     right with Tenant's concurrence to install additional or supplementary air
     conditioning units

                                       9
<PAGE>

      for the Leased premises, and the entire cost of installing, operating,
      maintaining and repairing the same shall be paid by Tenant to Landlord
      promptly after demand by Landlord.

          7.4  Limitation on Landlord's Liability.  Landlord shall not be liable
      for and Tenant shall not be entitled to terminate this Lease or to
      effectuate any abatement or reduction of rent by reason of Landlord's
      failure to provide or furnish any of the foregoing utilities or services
      if such failure was reasonably beyond the control of Landlord. In no event
      shall Landlord be liable for loss or injury to persons or property,
      however, arising or occurring in connection with or attributable to any
      failure to furnish such utilities or services even if within the control
      of Landlord, except in the event of Landlord's negligence or intentional
      conduct.

VIII. MAINTENANCE AND REPAIRS; ALTERATIONS; ACCESS

          8.1  Maintenance and Repairs by Landlord.  Landlord shall maintain in
      good order, condition and repair the structural components of the Leased
      Premises, including without limitation roof, exterior walls and
      foundations, as well as all repairs covered under construction warranties
      provided if Landlord is required to make structural repairs by reason of
      Tenant's negligent acts or omissions, Tenant shall pay Landlord's costs
      for making such repairs.

          8.2  Maintenance and Repairs by Tenant. Tenant, at Tenant's sole cost
      and expense and without prior demand being made, shall maintain the Leased
      Premises in good order, condition and repair, and will be responsible for
      the painting, carpeting or other interior design work of the Leased
      Premises beyond the initial construction phase as specified in Section 1.4
      and Exhibit "C" and "E" of the Lease and shall maintain all equipment and
      fixtures installed by Tenant. If repainting or recarpeting is required and
      authorized by Tenant, the cost for such are the sole obligation of Tenant
      and shall be paid for by Tenant immediately following the performance of
      said work and a presentation of an invoice for payment.

          8.3  Tenant Approval of Management and Maintenance Services. Tenant
      shall have the right to approve of persons who have or will contract with
      Landlord for Building and Property management and maintenance services. In
      addition, in the event that Tenant reasonably believes that another person
      could (i) provide better property management or maintenance service at the
      same or less cost than the person currently providing such property
      management or maintenance service, or (ii) provide equal property
      management or maintenance service for less cost, then Tenant shall, at its
      option, provide to Landlord the name and address of such person. Landlord
      agrees to take reasonable steps to verify that such person referred by
      Tenant could better or more economically provide the contracted for
      management and/or maintenance services for the Building and/or Property,
      then upon such verification, Landlord agrees to contract

                                      10
<PAGE>

     with and substitute such person to provide such service. The foregoing
     applies to services rendered pursuant to Articles 4, 7 and 8.

          8.4  Alterations.  Tenant shall not make or cause to be made any
     alterations, additions or improvements or install or cause to be installed
     any fixtures, signs, floor coverings, interior or exterior lighting,
     plumbing fixtures, or shades or awnings, or make any other changes to the
     Leased Premises without first obtaining Landlord's written approval, which
     approval shall not be unreasonably withheld.  Tenant shall present to the
     Landlord plans and specifications for such work at the time approval is
     sought.  In the event Landlord consents to the making of any alterations,
     additions, or improvements to the Leased Premises by Tenant, the same shall
     be made by Tenant at Tenant's sole cost and expense.  All such work with
     respect to any alterations, additions, and changes shall be done in a good
     and workmanlike manner and diligently prosecuted to completion such that,
     except as absolutely necessary during the course of such work, the Leased
     Premises shall at all times be a complete operating unit.  Any such
     alterations, additions, or changes shall be performed and done strictly in
     accordance with all laws and ordinances relating thereto.  In performing
     the work or any such alterations, additions, or changes, Tenant shall have
     the same performed in such a manner as not to obstruct access to any
     portion of the Building.  Any alterations, additions, or improvements to or
     of the Leased Premises, including, but not limited to, wallcovering, fume
     hoods, darkroom, paneling, and built-in cabinet work, but excepting movable
     furniture and equipment, shall at once become a part of the realty and
     shall be surrendered with the Premises, unless Landlord and Tenant agree at
     any time that the specific improvement may be removed by Tenant at the end
     of the Term provided Tenant restores the premises to its original
     condition, wear and tear excepted.  If there is an agreement to allow
     removal, such items which are the subject of agreement shall be listed on
     Exhibit F which agreement, as may be revised by the parties from time to
     time, shall be made a part of this Lease.  The parties have agreed as to
     the items 1 through 8 listed on Exhibit F.

          8.5  Landlord's Access to Leased Premises.  Landlord shall have the
     right to place, maintain, and repair all utility equipment of any kind in,
     upon, and under the Leased Premises as may be necessary for the servicing
     of the Leased Premises and other portion of the Building.  Landlord shall
     upon providing adequate notice to Tenant, also have the right to enter the
     Leased Premises at all times to inspect or to exhibit the same to
     prospective purchasers, mortgagees, tenants, and lessees, and to make such
     repairs, additions, alterations, or improvements as Landlord may deem
     desirable.  Landlord shall be allowed to take all material upon said Leased
     Premises that may be required therefor without the same constituting an
     actual or constructive eviction of Tenant in whole or in part and the rents
     reserved herein shall in no wise abate while said work is in progress by
     reason of loss or interruption of Tenant's business or otherwise, and
     Tenant shall have no claim for damages unless due to Landlord negligence.
     During the three (3) months prior to expiration of this Lease or of any
     renewal term, Landlord may place upon the Leased Premises "For Lease" or
     "For Sale" signs which Tenant shall permit to remain thereon.

                                      11
<PAGE>

IX.  ASSIGNMENT

          9.1  Assignment Prohibited.  Tenant shall not transfer, assign,
     mortgage, or hypothecate this Lease, in whole or in part, or permit the use
     of the Leased Premises by any person or persons other than Tenant, or
     sublet the Leased Premises, or any part thereof, without the prior written
     consent of Landlord in each instance, which consent shall not be
     unreasonably withheld, provided sufficient information is provided to
     Landlord to accurately represent the financial condition of those to whom
     this Lease will be transferred, assigned, mortgaged, or hypothecated.  Such
     prohibition against assigning or subletting shall include any assignment or
     subletting by operation of law.  Any transfer of this Lease from the Tenant
     by merger, consolidation, transfer of assets, or liquidation shall
     constitute an assignment for purposes of this Lease.  In the event that
     Tenant hereunder is a corporation, an unincorporated association, or a
     partnership, the transfer, assignment, or hypothecation of any stock or
     interest in such corporation, association, or partnership in the aggregate
     in excess of forty-nine percent (49%) shall be deemed an assignment within
     the meaning of this Section.  The above prohibition of assignment will not
     apply in the case of a registered offering of shares by Tenant or the
     public trading of registered shares subsequent to an initial offering.

          9.2  Consent Required.

          (a)  Any assignment or subletting without Landlord's consent shall be
     void, and shall constitute a default hereunder which, at the option of
     Landlord, shall result in the termination of this Lease or exercise of
     Landlord's other remedies hereunder. Consent to any assignment or
     subletting shall not operate as a waiver of the necessity for consent to
     any subsequent assignment or subletting, and the terms of such consent
     shall be binding upon any person holding by, under, or through Tenant.

          (b)  Landlord shall have no obligation to consent to the proposed
     sublease or assignment if the proposed sublessee or assignee or its
     business is or may be subject to compliance with additional requirements of
     the law, including any related rules or regulations, commonly known as the
     "Americans with Disabilities Act of l990" or similar state or local laws
     relating to persons with disabilities beyond those requirements which are
     applicable to the tenant desiring to so sublease or assign".

          9.3  Landlord's Right in Event of Assignment.  If this Lease is
     assigned or if the Leased Premises or any portion thereof are sublet or
     occupied by any person other than the Tenant, Landlord may collect rent and
     other charges from such assignee or other party, and apply the amount
     collected to the rent and other charges reserved hereunder, but such
     collection shall not constitute consent or waiver of the necessity of
     consent to such assignment, subleasing, or other transfer, nor shall such
     collection constitute the

                                      12
<PAGE>

     recognition of such assignee, sublessee, or other party as the Tenant
     hereunder or a release of Tenant from the further performance of all of the
     covenants and obligations, including obligation to pay rent, of Tenant
     herein contained. In the event that Landlord shall consent to a sublease or
     assignment hereunder, Tenant shall pay to Landlord reasonable fees, not to
     exceed $100.00, incurred in connection with processing of documents
     necessary to the giving of such consent. In the event Landlord consents to
     the assignment as provided by paragraph 9.1, then Tenant shall be released
     from further performance of any covenant and obligation under this Lease.

               9.4  Tenant's Right to Assign. For purposes of this Section 9.4,
     the term "Leases" means this Lease and the following two (2) lease
     agreements: (i) that certain Lease Agreement dated October 12, 1995 between
     Boyer-Foothill Associates, Ltd., as Landlord, and Tenant; and (ii) that
     certain Lease Agreement dated March 1, 1998 between Landlord and Tenant.
     Notwithstanding any other provision of this Section 9 to the contrary,
     Tenant shall have the right to assign its entire right, title and interest
     as tenant under all of the Leases to the University of Utah (the
     "University"), without first obtaining Landlord's prior written consent;
     provided, Tenant shall give Landlord not less than thirty (30) days prior
     written notice of such assignment and shall provide Landlord with copies of
     all documents, agreements and instruments related to the assignment. In the
     event of an assignment of the Tenant's rights and obligations to the
     University, and subject to obtaining the written agreement by the
     University to assume and perform all of the obligations of Tenant under the
     Leases (in form and substance reasonably acceptable to Landlord), Landlord
     shall recognize the University as the successor to Tenant under this Lease
     and such written agreement shall accomplish the release of Tenant of and
     from the further performance of any and all covenants and obligations under
     this Lease. Tenant shall have the right to assign its entire right, title
     and interest as tenant under all of the Leases to an entity or person which
     proposes to use the Leased Premises for purposes which are consistent with
     all covenants, rules, conditions and reversions governing the Research
     Park, whose net worth is equal to or greater than that of Tenant at the
     time of Tenant's execution of this Lease and whose credit worthiness is
     equal to or better than that of Tenant's creditworthiness at the time of
     Tenant's execution of this Lease (a "Creditworthy Successor Tenant"),
     subject to the Landlord's prior written consent, which consent shall not be
     unreasonably withheld or delayed. In connection with such request, Tenant
     shall furnish Landlord with all information reasonably required to evaluate
     the net worth or creditworthiness of the proposed assignee and copies of
     all documents, agreements and instruments relating to the proposed
     assignment. In the event of an assignment of Tenant's rights and
     obligations to a Creditworthy Successor Tenant as contemplated herein, and
     subject to obtaining the written agreement o the assignee to assume and
     perform all of the obligations of Tenant under the Leases, landlord shall
     recognize such assignee as the successor to Tenant under this lease and
     such written agreement shall accomplish the release of Tenant of and from
     the further performance of any and all covenants and obligations under this
     Lease.

                                      13
<PAGE>

X.   INDEMNITY

          10.1  Indemnification.  Tenant and Landlord shall indemnify each
     other and save each other harmless from and against any and all suits,
     actions, damage and claims, liability and expense in connection with loss
     of life, bodily or personal injury, or property damage arising from or out
     of any occurrence in, upon, at or from the Leased Premises, or occasioned
     wholly or in part by any act or omission of Tenant or Landlord, their
     agents, contractors, employees, servants, invitees, licensees or
     concessionaires. All insurance policies carried by Tenant and Landlord
     shall include a waiver of subrogation endorsement which specifies that the
     insurance carrier(s) will waive any right of subrogation against Tenant
     and/or Landlord arising out of any insurance claim.

          10.2  Release of Landlord.  Landlord shall not be responsible or
     liable at any time for any loss or damage to Tenant's personal property or
     to Tenant's business.  Tenant shall store its property in and shall use and
     enjoy the Leased Premises and all other portions of the Building and
     Improvements at its own risk, and hereby releases Landlord, to the full
     extent permitted by law, from all claims of every kind resulting in loss of
     life, personal or bodily injury, or property damage.

          10.3  Notice.  Tenant shall give prompt notice to Landlord in case of
     fire or accidents in the Leased Premises or in the Building of which the
     Leased Premises are a part or of defects therein or in any fixtures or
     equipment.

          10.4  Litigation.  In case Landlord, without fault on its part, shall
     be made a party to any litigation commenced against Tenant, then Tenant
     shall protect and hold Landlord harmless and shall pay all costs, expenses,
     and reasonable attorneys' fees.

 XI. INSURANCE

          11.1  Fire and "All Risk" Insurance on Tenant's Personal Property and
     Fixtures. At all times during the term of this Lease, Tenant shall keep in
     force at its sole cost and expense, fire insurance and "All Risk" insurance
     (including vandalism and malicious mischief) equal to the replacement cost
     of Tenant Finish, Tenant's fixtures, furnishings, equipment, and contents
     upon the Leased Premises and all improvements or additions made by Tenant
     to the Leased Premises. The Landlord shall be named as an additional
     insured on all such policies.

          11.2  Liability Insurance.  Tenant shall, during the entire term
     hereof, keep in full force and effect a policy of public liability and
     property damage insurance to include contractual coverage with respect to
     the Leased Premises and the business operated by Tenant in the Leased
     Premises, with a combined single limit for personal or bodily injury and
     property damage of not less than $1,000,000.00.  The policy shall name
     Landlord, any person, firms, or corporations designated by Landlord, and
     Tenant as insureds, and

                                      14
<PAGE>

      shall contain a clause that the insurer will not cancel or materially
      change the insurance pertaining to the Leased Premises without first
      giving Landlord ten (10) days written notice. Tenant shall at all times
      during the term hereof provide Landlord with evidence of current insurance
      coverage. All public liability, property damage, and other liability
      policies shall be written as primary policies, not contributing with
      coverage which Landlord may carry.

          11.3  Property Coverage.  Landlord shall obtain and maintain in force
      an "all-risk type" or equivalent policy form, and shall include fire,
      theft, extended coverages, vandalism and malicious mischief on the
      Building during the Lease period and any extension thereof. At the
      Landlord's discretion coverage for flood and earthquake may be obtained if
      commercially available at reasonable rates. Such insurance shall also
      include coverage against loss of rental income. Tenant shall pay Landlord
      as an expense covered in Basic Costs the cost to purchase the insurance
      called for in this paragraph.

          11.4  Subrogation.  Tenant and Landlord each waive its right of
      subrogation against each other for any reason whatsoever.

          11.5  Lender.  Any mortgage lender interest in any part of the
      Building or Improvements may, at Landlord's option, be afforded coverage
      under any policy required to be secured by Tenant hereunder, by use of a
      mortgagee's endorsement to the policy concerned.

 XII. DESTRUCTION

          If the Leased Premises shall be partially damaged by any casualty
      insured against under any insurance policy maintained by Landlord,
      Landlord shall, upon receipt of the insurance proceeds, repair the Leased
      Premises and until repair is complete the Basic Annual Rent and Additional
      Rent shall be abated proportionately as to that portion of the Leased
      Premises rendered untenantable. Notwithstanding the foregoing, if: (a) the
      Leased Premises by reason of such occurrence are rendered wholly
      untenantable, or (b) the Leased Premises should be damaged as a result of
      a risk which is not covered by insurance, or (c) the Leased Premises
      should be damaged in whole or in part during the last six (6) months of
      the term or of any renewal hereof, or (d) the Leased Premises or the
      Building (whether the Leased Premises are damaged or not) should be
      damaged to the extent of fifty percent (50%) or more of the then-monetary
      value thereof, then and in any such events, Landlord may either elect to
      repair the damage or may cancel this Lease by notice of cancellation
      within Ninety (90) days after such event and thereupon this Lease shall
      expire, and Tenant shall vacate and surrender the Leased Premises to
      Landlord. Tenant's liability for rent upon the termination of this Lease
      shall cease as of the day following Landlord's giving notice of
      cancellation. In the event Landlord elects to repair any damage, any
      abatement of rent shall end five (5) days after notice by Landlord to
      Tenant that the Leased Premises have been repaired. If the damage is
      caused by the

                                      15
<PAGE>

      negligence of Tenant or its employees, agents, invitees, or
      concessionaires, there shall be no abatement of rent. Unless this Lease is
      terminated by Landlord, Tenant shall repair and refixture the interior of
      the Leased Premises to the extent of the Tenant Finish in a manner and in
      at least a condition equal to that existing prior to the destruction or
      casualty.

XIII. CONDEMNATION

          13.1  Total Condemnation.  If the whole of the Leased Premises shall
      be acquired or taken by condemnation proceeding, then this Lease shall
      cease and terminate as of the date of title vesting in such proceeding.

          13.2  Partial Condemnation.  If any part of the Leased Premises shall
      be taken as aforesaid, and such partial taking shall render that portion
      not so taken unsuitable for the business of Tenant, then this Lease shall
      cease and terminate as aforesaid. If such partial taking is not extensive
      enough to render the Leased Premises unsuitable for the business of
      Tenant, then this Lease shall continue in effect except that the Basic
      Annual Rent and Additional Rent shall be reduced in the same proportion
      that the portion of the Leased Premises (including basement, if any) taken
      bears to the total area initially demised and Landlord shall, upon receipt
      of the award in condemnation, make all necessary repairs or alterations to
      the Building in which the Leased Premises are located, provided that
      Landlord shall not be required to expend for such work an amount in excess
      of the amount received by Landlord as damages for the part of the Leased
      Premises to taken. "Amount received by Landlord" shall mean that part of
      the award in condemnation which is free and clear to Landlord of any
      collection by mortgage lenders for the value of the diminished fee.

          13.3  Landlord's Option to Terminate.  If more than twenty percent
      (20%) of the Building shall be taken as aforesaid, Landlord may, by
      written notice to Tenant, terminate this Lease. If this Lease is
      terminated as provided in this Section, rent shall be paid up to the day
      that possession is so taken by public authority and Landlord shall make an
      equitable refund of any rent paid by Tenant in advance.

          13.4  Award.  Tenant shall not be entitled to and expressly waives all
      claim to any condemnation award for any taking, whether whole or partial
      and whether for diminution in value of the leasehold or to the fee,
      although Tenant shall have the right, to the extent that the same shall
      not reduce Landlord's award, to claim from the condemnor, but not from the
      Landlord, such compensation as may be recoverable by Tenant in its own
      right for damages to Tenant Finish, Tenant's business and fixtures or
      equipment.

          13.5  Definition.  As used in this Part XIII the term "condemnation
      proceeding" means any action or proceeding in which any interest in the
      Leased Premises is taken for

                                      16
<PAGE>

     any public or quasi-public purpose by any lawful authority through exercise
     of eminent domain or right of condemnation or by purchase or otherwise in
     lieu thereof.

XIV. LANDLORD'S RIGHTS TO CURE

          14.1  General Right.  In the event of breach, default, or
     noncompliance hereunder by Landlord, Tenant shall, before exercising any
     right or remedy available to it, give Landlord written notice of the
     claimed breach, default, or noncompliance.  If prior to its giving such
     notice Tenant has been notified in writing (by way of Notice of Assignment
     of Rents and Leases, or otherwise) of the address of a lender which has
     furnished any of the financing referred to in Part XV hereof, concurrently
     with giving the aforesaid notice to Landlord, Tenant shall, by registered
     mail, transmit a copy thereof to such lender.  For the fifteen (15) days
     following the giving of the notice(s) required by the foregoing portion of
     this section (or such longer period of time as may be reasonably required
     to cure a matter which, due to its nature, cannot reasonably be rectified
     within fifteen (15) days), Landlord shall have the right to cure the
     breach, default, or noncompliance involved.  If Landlord has failed to cure
     a default within said period, any such lender shall have an additional
     fifteen (15) days within which to cure the same or, if such default cannot
     be cured within that period, such additional time as may be necessary if
     within such fifteen (15) day period said lender has commenced and is
     diligently pursuing the actions or remedies necessary to cure the breach
     default, or noncompliance involved (including, but not limited to,
     commencement and prosecution of proceedings to foreclose or otherwise
     exercise its rights under its mortgage or other security instrument, if
     necessary to effect such cure), in which event this Lease shall not be
     terminated by Tenant so long as such actions or remedies are being
     diligently pursued by said lender.

          14.2  Mechanic's Lien.  Should any mechanic's or other lien be filed
     against the Leased Premises or any part thereof by reason of Tenant's acts
     or omissions or because of a claim against Tenant, Tenant shall cause the
     effect of the same to be cancelled and discharged or bonded over or
     otherwise within ten (10) days after written notice by Landlord.

 XV. FINANCING; SUBORDINATION

          15.1  Subordination.  Tenant acknowledges that it might be necessary
     for Landlord or its successors or assigns to secure mortgage loan financing
     or refinancing affecting the Leased Premises.  Tenant also acknowledges
     that the lender interested in any given loan may desire that Tenant's
     interest under this Lease be either superior or subordinate to the mortgage
     then held or to be taken by said Lender.  Accordingly, Tenant agrees that
     at the request of Landlord at any time and from time to time Tenant shall
     execute and deliver to Landlord an instrument, in form reasonably
     acceptable to Landlord and Tenant, whereby Tenant subordinates its interest
     under this Lease and in the Leased

                                      17
<PAGE>

     Premises to such of the following encumbrances as may be specified by
     Landlord: Any mortgage or trust deed and customary related instruments are
     herein collectively referred to merely as a "Mortgage" and securing a loan
     obtained by Landlord or its successors or assigns for the purpose of
     enabling acquisition of the Building and/or construction of additional
     improvements to provide permanent financing for the Building, or for the
     purpose of refinancing any such construction, acquisition, standing or
     permanent loan. Provided, however, that any such instrument or
     subordination executed by Tenant shall provide that so long as Tenant
     continues to perform all of its obligations under this Lease its tenancy
     shall remain in full force and effect notwithstanding Landlord's default in
     connection with the Mortgage concerned or any resulting foreclosure or sale
     or transfer in lieu of such proceedings. Tenant shall not subordinate its
     interests hereunder or in the Leased Premises to any lien or encumbrance
     other than the Mortgages described in and specified pursuant to this
     Section 15.1 without the prior written consent of Landlord and of the
     lender interested under each mortgage then affecting the Leased Premises.
     Any such unauthorized subordination by Tenant shall be void and of no force
     or effect whatsoever.

          15.2  Attornment.  Any sale, assignment, or transfer of Landlord's
     interest under this Lease or in the Leased Premises including any such
     disposition resulting from Landlord's default under a mortgage, shall be
     subject to this Lease and also Tenant shall attorn to Landlord's successor
     and assigns and shall recognize such successor or assigns as Landlord under
     this Lease, regardless of any rule of law to the contrary or absence of
     privity of contract.

          15.3  Financial Information.  As a condition to Landlord's acceptance
     of this Lease, Tenant shall provide financial information sufficient to
     verify to Landlord the financial condition of Tenant.  Tenant hereby
     represents and warrants that none of such information contains or will
     contain any untrue statement of material fact, nor will such information
     omit any material fact necessary to make the statements contained therein
     misleading or unreliable.  Any financial information provided by Tenant
     shall beheld in confidence and distributed only to Landlord's investors or
     lenders for the Leased Premises.

XVI. EVENTS OF DEFAULT; REMEDIES OF LANDLORD

          16.1  Default by Tenant.  Upon the occurrence of any of the following
     events, Landlord shall have the remedies set forth in Section 16.2:

          (a)   Tenant fails to pay any installment of Basic Annual Rent or
Estimated Costs or any other sum due hereunder within ten (10) days after Tenant
receives written notice of rent due.

                                      18
<PAGE>

          (b)   Tenant fails to perform any other term, condition, or covenant
     to be performed by it pursuant to this Lease within ten (10) days after
     written notice of such default shall have been given to Tenant by Landlord
     or, if cure would reasonably require more than ten (10) days to complete,
     if Tenant fails to commence performance within the ten (10) day period or
     fails diligently to pursue such cure to completion.

          (c)   Tenant shall become bankrupt or insolvent or file any debtor
     proceedings or have taken against such party in any court pursuant to state
     or federal statute, a petition in bankruptcy or insolvency, reorganization,
     or appointment of a receiver or trustee; or Tenant petitions for or enters
     into an arrangement; or suffers this Lease to be taken under a writ of
     execution.

          16.2  Remedies.   In the event of any default by Tenant hereunder,
      Landlord may at any time, without waiving or limiting any other right or
      remedy available to it, terminate Tenant's rights under this Lease by
      written notice, reenter and take possession of the Premises by any lawful
      means (with or without terminating this Lease), or pursue any other remedy
      allowed by law. Tenant agrees to pay to Landlord the cost of recovering
      possession of the Premises, all costs of reletting, and arising out of
      Tenant's default, including attorneys' fees. Notwithstanding any reentry,
      the liability of Tenant for the rent reserved herein shall not be
      extinguished for the balance of the Term, and Tenant agrees to compensate
      Landlord upon demand for any deficiency arising from reletting the
      Premises at a lesser rent than applies under this Lease.

          16.3  Past Due Sums; Penalty.  If Tenant fails to pay, when the same
      is due and payable, any Basic Annual Rent, Estimated Costs and electrical
      charges within ten (10) days after the same is due and payable, or other
      sum required to be paid by it hereunder, such unpaid amounts shall bear
      interest from the due date thereof to the date of payment at a fluctuating
      rate equal to two percent (2%) per annum above the prime rate of interest
      charged by Zions Bank, Salt Lake City, Utah. In addition thereto, Tenant
      shall pay a sum of two percent (2%) of such unpaid amounts as a service
      fee. Notwithstanding the foregoing, however, Landlord's right concerning
      such interest and service fee shall be limited by the maximum amount which
      may properly be charged by Landlord for such purposes under applicable
      law.

XVII. PROVISIONS APPLICABLE AT TERMINATION OF LEASE

          17.1  Surrender of Premises.  At the expiration of this Lease, except
      for changes made by Tenant that were approved by Landlord, Tenant shall
      surrender the Leased Premises in the same condition, less reasonable wear
      and tear, as they were in upon delivery of possession thereto under this
      Lease and shall deliver all keys to Landlord.  Before surrendering the
      Leased Premises, Tenant shall remove all of its personal property
      including, but not limited to, those items showing on Exhibit "F" and
      trade fixtures and

                                      19
<PAGE>

       such property or the removal thereof shall in no way damage the Leased
       Premises, and Tenant shall be responsible for all costs, expenses and
       damages incurred in the removal thereof. If Tenant fails to remove its
       personal property and fixtures upon the expiration of this Lease, the
       same shall be deemed abandoned and shall become the property of Landlord.

          17.2  Holding Over.  Any holding over after the expiration of the term
       hereof or of any renewal term shall be construed to be a tenancy from
       month to month at such rates as Landlord may designate and on the terms
       herein specified so far as possible. Landlord may not in any event raise
       the rent above 110% of the last month's rent.

XVIII. ATTORNEYS' FEES

       In the event that at any time during the term of this Lease either
Landlord or the Tenant institutes any action or proceeding against the other
relating to the provisions of this Lease or any default hereunder, then the
unsuccessful party in such action or proceeding agrees to reimburse the
successful party for the reasonable expenses of such action including reasonable
attorneys' fees, incurred therein by the successful party.

XIX. ESTOPPEL CERTIFICATE

          19.1  Landlord's Right to Estoppel Certificate.  Tenant shall, within
      fifteen (15) days after Landlord's request, execute and deliver to
      Landlord a written declaration, in form and substance similar to Exhibit
      "D", in recordable form: (1) ratifying this Lease; (2) expressing the
      Commencement Date and termination date hereof; (3) certifying that this
      Lease is in full force and effect and has not been assigned, modified,
      supplemented or amended (except by such writing as shall be stated); (4)
      that, if true, all conditions under this Lease to be performed by Landlord
      have been satisfied; (5) that there are no defenses or offsets against the
      enforcement of this Lease by the Landlord, or stating those claimed by
      Tenant; (6) the amount of advance rental, if any, (or none if such is the
      case) paid by Tenant; (7) the date to which rental has been paid; (8) the
      amount of security deposited with Landlord; and (9) such other information
      as Landlord may reasonably request. Landlord's mortgage lenders and/or
      purchasers shall be entitled to rely upon such declaration.

          19.2  Effect of Failure to Provide Estoppel Certificate.  Tenant's
      failure to furnish any Estoppel Certificate within fifteen (15) days after
      request therefor shall be deemed a default hereunder and moreover, it
      shall be conclusively presumed that: (a) this Lease is in full force and
      effect without modification in accordance with the terms set forth in the
      request; (b) that there are no unusual breaches or defaults on the part of
      the Landlord; and (c) no more than one (1) month's rent has been paid in
      advance.

                                      20
<PAGE>

XX.   PARKING

      Automobiles of Tenant and all visitors associated with Tenant shall be
parked only within parking areas designated by Landlord for parking.  Landlord
or its agents shall, without any liability to Tenant or its occupants, have the
right to cause to be removed any automobile that may be wrongfully parked in a
prohibited or reserved parking area, and Tenant agrees to indemnify, defend and
hold Landlord harmless from and against any and all claims, losses, demands,
damages and liabilities asserted or arising with respect to or in connection
with any such removal of an automobile except due to Landlord's negligence.

XXI.  SIGNS, AWNINGS, AND CANOPIES

      Tenant shall not place or suffer to be placed or maintained on any
exterior door, wall, or window of the Leased Premises, or elsewhere in the
Building, any sign, awning, marquee, decoration, lettering, attachment, or
canopy, or advertising matter or other thing of any kind, and will not place or
maintain any decoration, lettering, or advertising matter on the glass of any
window or door of the Leased Premises without obtaining the proper authorization
from Salt Lake County prior to installing. Tenant will otherwise be free to
install signage of its choice.

XXII. MISCELLANEOUS PROVISIONS

          22.1  No Partnership.  Landlord does not by this Lease, in any way or
      for any purpose, become a partner or joint venturer of Tenant in the
      conduct of its business or otherwise.

          22.2  Force Majeure.  Landlord shall be excused for the period of any
      delay in the performance of any obligations hereunder when prevented from
      so doing by cause or causes beyond Landlord's control, including labor
      disputes, civil commotion, war, governmental regulations or controls, fire
      or other casualty, inability to obtain any material or service, or acts of
      God.

          22.3  No Waiver.  Failure of Landlord or Tenant to insist upon the
      strict performance of any provision or to exercise any option hereunder
      shall not be deemed a waiver of such breach by Landlord or Tenant.  No
      provision of this Lease shall be deemed to have been waived unless such
      waiver be in writing signed by Landlord or Tenant, as the case may be.

          22.4  Notice.  Any notice, demand, request, or other instrument which
      may be or is required to be given under this Lease shall be (i) given by
      facsimile, (ii) delivered in person or (iii) sent by United States
      certified or registered mail, postage prepaid and shall be addressed (a)
      if to Landlord, at the place specified for payment of rent, and (b) if to
      Tenant, either at the Leased Premises or at any other current address for
      Tenant which is
                                      21
<PAGE>

     known to Landlord. Either party may designate such other address as shall
     be given by written notice or by facsimile transmission.

     Landlord:  BOYER RESEARCH PARK ASSOCIATES VI
                C/O THE BOYER COMPANY
                127 SOUTH 500 EAST, SUITE 100
                SALT LAKE CITY, UTAH 84102
                (801) 521-4781/FAX (801) 521-4793
                ATTENTION:  B. GREG GARDNER

     Tenant:    MYRIAD GENETICS, INC.
                320 WAKARA WAY
                SALT LAKE CITY, UTAH 84108
                (801) 582-3400/FAX (801) 584-3640
                ATTENTION:  JAY MOYES

                PARSONS, BEHLE & LATIMER
                201 SOUTH MAIN
                SALT LAKE CITY, UTAH 84111
                (801) 532-1234/FAX (801) 536-6111
                ATTENTION:  JON BUTLER

          22.5  Captions; Attachments; Defined Terms.

          (a)   The captions to the section of this Lease are for convenience of
     reference only and shall not be deemed relevant in resolving questions of
     construction or interpretation under this Lease.

          (b)   Exhibits referred to in this Lease, and any addendums and
     schedules attached to this Lease shall be deemed to be incorporated in this
     Lease as though part thereof.

          22.6  Recording.  Tenant may record this Lease or a memorandum thereof
     with the written consent of Landlord, which consent shall not be
     unreasonably withheld. Landlord, at its option and at any time, may file
     this Lease for record with the Recorder of the County in which the Building
     is located.

          22.7  Partial Invalidity.  If any provision of this Lease or the
     application thereof to any person or circumstance shall to any extent be
     invalid, the remainder of this Lease or the application of such provision
     to persons or circumstances other than those as to which it is held invalid
     shall not be affected thereby and each provision of this Lease shall be
     valid and enforced to the fullest extent permitted by law.

                                      22
<PAGE>

          22.8  Broker's Commissions.  Tenant and Landlord represent and warrant
     to each other that there are no claims for brokerage commissions or
     finder's fees in connection with this Lease and agree to indemnify each
     other against and hold them harmless from all liabilities arising from such
     claim, including any attorneys' fees connected therewith.

          22.9  Tenant Defined:  Use of Pronouns.  The word "Tenant" shall be
     deemed and taken to mean each and every person or party executing this
     document as a Tenant herein.  If there is more than one person or
     organization set forth on the signature line as the Tenant, their liability
     hereunder shall be joint and several.  If there is more than one Tenant,
     any notice required or permitted by the terms of this Lease may be given by
     or to any one thereof, and shall have the same force and effect as if given
     by or to all thereof.  The use of the neuter singular pronoun to refer to
     Landlord or Tenant shall be deemed a proper reference even though Landlord
     or Tenant may be an individual, a partnership, a corporation, or a group of
     two or more individuals or corporation.  The necessary grammatical changes
     required to make the provisions of this Lease apply in the plural sense
     where there is more than one Landlord or Tenant and to corporations,
     associations, partnerships, or individuals, males or females, shall in all
     instances be assumed as though in each case fully expressed.

          22.10  Provisions Binding, Etc.  Except as otherwise provided, all
     provisions herein shall be binding upon and shall inure to the benefit of
     the parties, their legal representatives, heirs, successors, and assigns.
     Each provision to be performed by Tenant shall be construed to be both a
     covenant and a condition. In the event of a sale or assignment (except for
     purposes of security or collateral) by Landlord of all of (i) the Building,
     (ii) the Leased Premises, or (iii) this Lease, to an unrelated third party
     (the "Buyer") reasonably acceptable to Tenant, Landlord shall, from and
     after the date of such sale or assignment, be entirely relieved of all of
     its obligations under this Lease, provided that (i) such Buyer fully
     assumes all of the obligations of Landlord under this Lease, and (ii)
     Tenant's rights and benefits under this Lease continue in full force and
     effect following the date of such sale or assignment.

          22.11  Entire Agreement, Etc.  This Lease and the Exhibits, Riders,
     and/or Addenda, if any, attached hereto, constitute the entire agreement
     between the parties.  All Exhibits, riders, or addenda mentioned in this
     Lease are incorporated herein by reference.  Any prior conversations or
     writings are merged herein and extinguished.  No subsequent amendment to
     this Lease shall be binding upon Landlord or Tenant unless reduced to
     writing and signed.  Submission of this Lease for examination does not
     constitute an option for the Leased Premises and becomes effective as a
     lease only upon execution and delivery thereof by Landlord to Tenant.  If
     any provision contained in the rider or addenda is inconsistent with a
     provision in the body of this Lease, the provision contained in said rider
     or addenda shall control.  The captions and Section numbers appearing
     herein are inserted only as a matter of convenience and are not intended to
     define, limit, construe, or describe the scope or intent of any section or
     paragraph.

                                      23
<PAGE>

          22.12  Governing Law.  The interpretation of this Lease shall be
     governed by the laws of the State of Utah.  The parties hereto expressly
     and irrevocably agree that either party may bring any action or claim to
     enforce the provisions of this Lease in the State of Utah, County of Salt
     Lake, and each party irrevocably consents to personal jurisdiction in the
     State of Utah for the purposes of any such action or claim.  Each party
     further irrevocably consents to service of process in accordance with the
     provisions of the laws of the State of Utah.  Nothing herein shall be
     deemed to preclude or prevent the parties hereto from bringing any action
     or claim to enforce the provisions of this Lease in any other appropriate
     place or forum.

          22.13  Ground Lease Notice.  Landlord shall provide notice to Tenant
     within three (3) business days of the occurrence of either of the following
     under the ground lease pursuant to which Landlord leases the Property
     described on Exhibit "A" and/or the documents evidencing a construction or
     a permanent loan secured by the Property: (i) an event of default on the
     part of Landlord or (ii) Landlord's receipt of notice that (A) Landlord is
     in default under such documents or (B) that with the passage of time
     Landlord will be in default under such documents.

     IN WITNESS WHEREOF, the Landlord and Tenant have executed this Lease on the
day first set forth above.

                                   LANDLORD:  BOYER RESEARCH PARK ASSOCIATES
                                              VI, BY ITS GENERAL PARTNER, THE
                                              BOYER COMPANY, L.C.

                                              By: /s/ H. Roger Boyer
                                                  ---------------------------
                                                  H. Roger Boyer
                                                  Chairman and Manager

                                   TENANT:    MYRIAD GENETICS, INC.

                                              By: /s/ Jay Moyes
                                                  ---------------------------
                                                  Jay Moyes
                                                  Chief Financial Officer

                                      24
<PAGE>

                                    NOTARY

STATE OF UTAH            )
                         )  ss
COUNTY OF SALT LAKE      )

     On this______ day of _____________________, 200____, personally appeared
before me H. ROGER BOYER, who duly acknowledged to me that he executed the
foregoing Lease as the CHAIRMAN AND MANAGER of THE BOYER COMPANY, L. C., A UTAH
LIMITED LIABILITY COMPANY, the managing partner of BOYER RESEARCH PARK
ASSOCIATES VI.

My commission Expires:                 ____________________________________
                                       Notary Public
                                       Residing at SALT LAKE COUNTY
____________________________

STATE OF______________     )
                           )  ss
COUNTY OF_____________     )

     On this _____ day of ______, 200___, personally appeared before me JAY
MOYES, who being duly sworn, did say that he is the CHIEF OPERATING OFFICER of
MYRIAD GENETICS, INC., a DELAWARE Corporation, and that said instrument was
signed in behalf of said corporation by authority of its by-laws or a resolution
of its Board of Directors, and said JAY MOYES acknowledged to me that said
corporation executed the same.

My Commission Expires:

                                       ____________________________________
_____________________                  Notary Public
                                       Residing at_________________________

                                      25
<PAGE>

                                     RIDER

                        THIS RIDER IS INCORPORATED INTO
                  THE LEASE AGREEMENT AND MADE A PART THEREOF

A.   Tenant's Right of First Refusal to Purchase Building
     ----------------------------------------------------

     Landlord grants to Tenant the right of first refusal exercisable after the
Commencement Date during the term of the Lease to purchase the Building (the
"Right of First Refusal").  If at any time after the Commencement Date during
the term of this Lease Landlord shall desire to accept an offer from a third
person to purchase the Building, it shall provide written notice of such intent
to Tenant together with a copy of the offer.  Tenant shall have twenty (20) days
to elect to purchase the Building strictly upon the terms and conditions,
including price, as set forth in the offer.  If Tenant does not timely exercise
the Right of First Refusal, this Right of First Refusal shall expire and
Landlord may thereafter sell the Building upon terms and conditions, including
price, which are not more favorable to the buyer that is set forth in the offer.
If Landlord does not close the sale of the Building to such third person,
Tenant's Right of First Refusal shall continue.  This Right of First Refusal
shall not apply to a foreclosure sale, trustee's sale or deed in lieu of
foreclosure by or to a mortgage lender in respect of the Building.

B.   Tenant's Option to Purchase Building
     ------------------------------------

     1.   Commencing as of the Commencement Date and continuing throughout the
          term of the Lease, Tenant shall have the right and option to purchase
          all of Landlord's right, title and interest in the Building upon the
          terms and conditions set forth in this portion of the Rider (the
          "Purchase Option").  To exercise this Purchase Option, tenant shall
          give written notice of exercise to Landlord in the manner provided in
          the Lease.  Tenant may exercise the Purchase Option only if no
          default, or circumstance which with the giving of notice and/or the
          passage of time would constitute a default, is then existing.

     2.   The Purchase Price which Tenant shall pay to Landlord for its entire
          right, title and interest in the Building (the "Purchase Price") shall
          be the sum of the following:

          (a)  The amount of any prepayment fee, premium or similar charge
               incurred by Landlord in discharging any lien or encumbrance which
               secures any monetary obligation on the Building.

          (b)  The greater of:

               (i) the Fair Market Value (as defined below); and

                                      R-1
<PAGE>

               (ii)  one hundred and six percent (106%) of the Total Project
                     Cost (as defined below).

     3.   For purposes of this Purchase Option, the following terms shall have
          the meanings set forth:

          (a)  "Fair Market Value" means the value of the Building as agreed
               upon in writing by Landlord and Tenant or, if the Landlord and
               Tenant cannot agree upon such value within thirty (30) days after
               the Tenant exercises the Purchase Option, then either Landlord or
               Tenant may nominate three (3) qualified, independent appraisers
               to appraise the Building, each of whom shall:

               (i)   be a member in good standing of the Utah Chapter of the
                     Appraisal Institute;

               (ii)  be state certified under the Utah Real Estate Appraiser
                     Registration and Certification Act; and

               (iii) shall have not less than five (5) years of experience
                     valuing office buildings in Salt Lake County, Utah.

               The other party shall then select one (1) of the nominated
               appraisers to perform an appraisal to determine the Fair Market
               Value of the Building.  The costs and fees of the appraiser shall
               be paid in equal shares by Landlord and Tenant.  In determining
               the Fair Market Value it shall be assumed that all liens and
               encumbrances securing obligations to pay loans or other fixed or
               determinable sums have been discharged.

          (b)  "Total Project Cost" means any and all "hard" and "soft" direct
               costs and expenditures incurred by Landlord at any time in
               connection with the acquisition, design or construction of the
               Building, including, without limitation:

               (i)   all payments or obligations incurred to general and other
                     contractors;

               (ii)  all architectural, engineering and other professional fees
                     incurred;

               (iii) all permit and license fees and other charges of
                     governmental authorities incurred;

               (iv)  all cost and expense of insurance incurred prior to the
                     Commencement Date;

                                      R-2
<PAGE>

               (v)    all cost incurred prior to the Commencement Date in
                      connection with or arising from the ground lease
                      including, without limitation, legal fees and survey
                      costs;

               (vi)   all legal and accounting fees incurred which are
                      attributable to the development and construction of the
                      Building;

               (vii)  all cost incurred in connection with or arising from or in
                      connection with construction financing including, without
                      limitation, legal fees and survey costs; and

               (viii) all real estate taxes and assessments (or equivalent
                      privilege tax), utility charges and similar costs and
                      expenses in respect of the Building incurred prior to the
                      Commencement Date.

     4.   The closing, pursuant to the Purchase Option, shall occur thirty (30)
          days after the Purchase Price is determined.  At the closing:

          (a)  Tenant shall pay the Purchase Price in cash.

          (b)  Landlord shall convey title to the Building to Tenant by special
               warranty deed and shall be obligated to provide at Landlord's
               cost a standard owner's policy of title insurance.

          (c)  Landlord shall discharge all liens and encumbrances securing
               obligations to pay loans or other fixed or determinable sums or
               obligations owing to mechanics or materialmen.  Tenant shall take
               the Building subject to all other encumbrances and exceptions of
               record.

          (d)  Landlord shall represent and warrant to the best of its knowledge
               as to customary matters involving the condition of the Building.

          (e)  Each of the parties shall bear its costs and attorneys' fees in
               connection with the exercise and closing under the Purchase
               Option; provided, Landlord shall pay the premium on the policy of
               title insurance delivered to Tenant, and Landlord and Tenant
               shall each pay one-half (1/2) of the fees of the escrow agent.

     5.   If the Tenant exercises the Purchase Option but timely fails to close
          for any reason other than the fault of Landlord, the Purchase Option
          shall thereafter expire and shall no longer be enforceable.

                                      R-3
<PAGE>

     6.   Landlord and Tenant shall jointly record a notice of this Purchase
          Option and of the Right of First Refusal.

                                      R-4
<PAGE>

                                  EXHIBIT "A"

                         LEGAL DESCRIPTION OF PROPERTY
                         -----------------------------

                        TO BE PROVIDED AT A LATER DATE.

                                      A-1
<PAGE>

                                  EXHIBIT "B"

                     PLANS AND SPECIFICATIONS OF BUILDING
                     ------------------------------------

              EXHIBIT "B" TO BE PROVIDED FOLLOWING COMPLETION OF
                    ARCHITECTURAL PLANS AND SPECIFICATIONS.

                                      B-1
<PAGE>

                                  EXHIBIT "C"

                                  WORK LETTER
                                  -----------

                        CONSTRUCTION AND/OR FINISHING OF
                        IMPROVEMENTS TO LEASED PREMISES

     In accordance with the provisions of the body of the Lease to which this
Exhibit "C" is attached, the improvements to the Leased Premises shall be
constructed and/or finished (as the case may be) in the manner described, and
upon all of the terms and conditions contained in the following portion of this
Exhibit "C".

I.   CONSTRUCTION OF PHASE I BUILDING ("THE BUILDING"):
     -------------------------------------------------

          A.   Landlord agrees to erect at its sole cost and expense, the
Building described on Exhibit "B." Landlord shall build-out and finish the
Leased Premises according to Tenant's plans and specifications at Tenant's cost
and expense. The Building and the Leased Premises shall be constructed in a good
and workmanlike manner, with any change orders thereto approved by Landlord and
Tenant with respect to the Leased Premises pursuant to Article B below, and in
compliance with all applicable laws and ordinances. Preliminary Plans shall
provide for a completely finished building, of a type and quality that is
consistent with newly constructed first-class office buildings in the Salt Lake
City, Utah area, and shall include site plans showing all driveways, sidewalks,
parking areas that provide parking in an amount equal to two and 85/100 (2.85)
cars for every 1,000 Usable Square Feet in the Building, landscaping and other
site improvements. Without limiting the generality of the foregoing, Preliminary
Plans shall provide for a three (3) story building containing 57,243 rentable
square feet of space and shall be generally consistent with the conceptual plans
and drawings attached hereto as Exhibit "B" and incorporated herein (the
"Conceptual Drawings"). The build-out and interior finish work within the Leased
Premises shall be in accordance with plans and specifications that shall be
prepared by Landlord's architect, Jensen Haslem Campbell & Hardcastle
Architects, and engineers ("Tenant Finish Plans"). Tenant Finish Plans shall be
prepared in accordance with the time periods set forth to meet a July 1, 2001
Target Date. The Target Date shall be extended by any period of Tenant's delay
in providing decisions that need to be made in connection with the preparation
of Tenant Finish Plans.

          B.   Tenant may make changes to Final Plans only if Tenant signs a
change order requesting the change and then only if Landlord approves the change
by signing the change order, which approval shall not be unreasonably withheld,
conditioned, or delayed.  Landlord shall notify Tenant in writing, within five
(5) business days of Tenant's change order request, of its approval or detailed
reason of its disapproval of such change order and a good faith estimate of the
actual cost of such change order and any delay to the Target Date or in
achieving substantial completion that would result therefrom.  Tenant may,
within five (5) business days of its receipt of such estimate, elect to rescind
its request for such change order upon written notice to Landlord.  Landlord may
require changes in Final Plans only if Landlord and Tenant sign a

                                      C-1
<PAGE>

change order. The cost of any change orders that are necessary to comply with
applicable building codes and other laws shall be borne by Landlord, unless such
change orders are necessitated only because of (1) other change orders requested
by Tenant; (2) Tenant Finish Plans; (3) changes to Tenant Finish Plans; or (4)
Tenant's early occupancy to the Building prior to substantial completion of
Landlord's Work. Any change order shall be effective only when set forth on a
written change order executed by Landlord, Tenant, and the Base Building General
Contractor. By approving a change order, Tenant and Landlord shall agree to a
delay in Substantial Completion and to the Target Date, as specified therein, if
any.

     Tenant shall furnish Landlord with a written list of Tenant's authorized
construction representatives for Landlord's Work.  Only such construction
representatives are authorized to sign any change order, receipt, or other
document on behalf of Tenant related to Landlord's Work, and without the
signature of any one of such authorized construction representatives, no such
document shall be binding upon Tenant.  Tenant may, from time to time, change or
add to the list of authorized construction representatives by giving Landlord
written notice of the addition or change.  Landlord's authorized representative
shall be B. Greg Gardner, and until changed by written notice from Landlord to
Tenant, only B. Greg Gardner shall be authorized to sign change orders,
receipts, or other documents on behalf of Landlord related to Landlord's Work.

          C.   The Building Work shall be performed by a general contractor
selected by Landlord (the "Base Building General Contractor").

          D.   Landlord will cause Contractor to provide, at Contractor's
expense, an Owner's Protective Liability (OPL) Policy acceptable to Tenant.  The
Owner's Protective Liability Policy shall name Myriad Genetics, Inc. as the
Named Insured.  The policy will be provided by an insurance company rated A,
Class XV or better by Best's Key Rating Guide system.  The policy will maintain
a limit of liability of not less than five million dollars ($5,000,000.00).
Such insurance policy must be in force prior to the commencement of construction
operation of any kind.  The Contractor will also insure the Building at
Contractor's expense during the course of construction in an amount equal to or
greater than the value of the construction.  Insurance coverage shall be
provided by an insurance company rated A, Class XV or better by Best's Key
Rating Guide system.  Insurance coverage shall be provided on a coverage form
equal to or more comprehensive than Insurance Services Office (U.S.A.) Special
form.  Such insurance policy must be in force prior to construction operations
of any kind.

     II.  TENANT FINISH PLANS:
          -------------------

          A.   Landlord shall cause Jensen Haslem Campbell & Hardcastle
Architects (the "Architect") to prepare plans and specifications for the
interior improvement of the Building and the Leased Premises as necessary to
render the Leased Premises in first-class condition and suitable for the conduct
of Tenant's business (such improvement being referred to herein as the "Tenant
Finish").  Landlord shall require the Architect to meet periodically with Tenant
in connection with the preparation of the plans and, upon Landlord's approval
thereof (which approval shall not be unreasonably withheld), to incorporate
Tenant's requested features and specifications into the plans.  Landlord shall
submit a complete draft of the plans to Tenant by

                                      C-2
<PAGE>

September 1, 2001 (the "Base Line Date"). Tenant shall within seven (7) days
after the plans are submitted to them, either approve the plans in writing or
submit to Landlord a written itemization of all objections which Tenant may have
to the plans. If Tenant approves the plans, the plans shall be deemed final. If
Tenant submits to Landlord a written itemization of objections to the plans,
Landlord and Tenant shall negotiate in good faith to resolve Tenant's objections
to their mutual satisfaction. If Landlord and Tenant are able to resolve all of
Tenant's objections to their mutual satisfaction, then Landlord and Tenant shall
each approve the plans as modified to incorporate the resolution of Tenant's
objections and the plans as so modified shall be deemed final.

          B.   Changes to Plans.  After the plans are deemed final, the plans
               ----------------
shall not be subject to further change except as provided under this Paragraph.
If either Landlord or Tenant desires any change to the plans after they are
deemed final, it shall submit to the other for approval (which approval shall
not be unreasonably withheld) a proposed change order, in writing, setting forth
the change.  Thereupon the other party shall either approve the proposed change
order or notify the party submitting the proposed change order of its reason for
withholding such approval, within two (2) business days after receipt of the
proposed change order for approval.  Without limiting the reasons for which
approval of any proposed change order may be reasonably withheld, approval shall
be deemed to have been reasonably withheld if the proposed change (1) would
result in additional construction maintenance repair or replacement costs which
could not be fully borne by the party proposing the change, (2) would result in
a violation of any applicable law, regulation, ordinance or code, or (3) in the
case of a change proposed by Landlord would materially reduce the usable area of
the Building or would materially adversely affect the aesthetics of the Leased
Premises or the usability thereof for the conduct of Tenant's business.  Upon
approval of any proposed change order pursuant to this Paragraph, Landlord shall
cause the plans and construction contracts to be modified or amended as
necessary to reflect such change order.

          C.   Landlord's Construction Responsibilities.  Landlord shall be
               ----------------------------------------
fully responsible for the installation and construction of Tenant Finish,
including, without limitation, the following:  (1) the obtaining of all building
and sign permits, licenses and other approvals required to construct the Tenant
Finish; (2) the management and supervision of all architects, contractors,
subcontractors and material providers participating in the construction of the
Tenant Finish; (3) all necessary coordination with governmental entities having
jurisdiction over the Lease Premises and utility companies; (4) enforcement of
construction contracts; (5) security with respect to the Leased Premises during
the construction period; (6) quality control and inspection of work; (7)
construction clean up and refuse disposal; (8) construction timetables and
deadlines as necessary to comply with the Lease; (9) compliance with applicable
laws, regulations, ordinances and codes; and (10) all other matters relating to
the construction of the Tenant Finish, except as otherwise expressly provided in
the Lease. Landlord represents and covenants that upon the completion of the
Tenant Finish, the Leased Premises shall conform to the Tenant Finish Plans and
shall be in compliance with all applicable laws, regulations, ordinances, and
codes, including, without limitation, applicable building codes and
environmental laws. Tenant shall be entitled at any time during the construction
period to inspect the construction of the Tenant Finish, provided that such
inspection does not unreasonably interfere with the construction of the Tenant
Finish. No failure of Tenant to

                                      C-3
<PAGE>

conduct such inspections or to discover or assert any defect in connection
therewith shall constitute a waiver by Tenant of, or preclude Tenant from
thereafter asserting, any rights it may have with respect to any representation,
warranty or covenant made by Landlord with respect to the Leased Premises or the
Tenant Finish.

          D.   Construction Contracts.  Landlord shall act as general
               ----------------------
contractor with respect to, or install and construct using its own personnel,
all or portions of the Tenant Finish, provided, however, Landlord shall contract
with and use licensed, qualified and reputable companies or persons for the
performance of all such work to the extent Landlord is not licensed and fully
qualified to perform the same. Landlord shall be entitled to select all
contractors and material providers to perform work with respect to the Tenant
Improvements which Landlord does not elect to perform directly and to negotiate
the terms and conditions of the contracts with such contractors and material
providers. Notwithstanding Paragraphs C and D, Tenant may choose its own
contractor to perform Landlord's work pursuant to Paragraphs C and D.

          E.   Warranty.  Unless Tenant substitutes the contractor pursuant to
               --------
Paragraph D above, Landlord warrants to Tenant for one (1) year after the
Commencement Date of the Lease, that Tenant Finish shall be completed by
Landlord in a good and workmanlike manner, free from faulty materials, in
accordance with all applicable legal requirements, and sound engineering
standards, and in accordance with the Final Plans and Tenant Finish Plans.  Such
warranty includes, without limitation, the repair or replacement (including
labor), for one (1) year at Landlord's sole cost, of all materials, fixtures and
equipment which are defective or which are defectively installed by Landlord or
its agents in connection with Landlord's Work.  In addition, Landlord shall
obtain manufacturer's warranties, including, without limitation, for air
conditioner, compressors, and the roof of the Building.

          F.  Commencement Date Agreement.  When the Commencement Date has been
              ---------------------------
determined, Landlord and Tenant shall execute Exhibit D (attached) expressly
confirming the Commencement Date and the expiration date of the Initial Term of
this Lease and confirming, to the best knowledge of Tenant and Landlord, that
Substantial Completion has occurred.

          G.  Tenant's Construction Obligations.  Except as provided in
              ---------------------------------
paragraph C and D above, Tenant shall be fully responsible for the installation
of all of Tenant's trade fixtures, equipment, furnishings or decorations, except
to the extent such installation is contemplated or provided for in the Plans.
Landlord shall provide Tenant reasonable access to the Leased Premises for such
purposes.

                                      C-4
<PAGE>

                                 EXHIBIT  "D"

                      ACKNOWLEDGMENT OF COMMENCEMENT DATE
                      -----------------------------------
                        AND TENANT ESTOPPEL CERTIFICATE
                        -------------------------------

TO:                           DATE:

  RE: ______________________________________________________________
      ______________________________________________________________
      ______________________________________________________________
      ______________________________________________________________

Gentlemen:

     The undersigned, as Tenant, has been advised that the Lease has been or
will be assigned to you as a result of your financing of the above-referenced
property, and as an inducement therefor hereby confirms the following:

1.   That it has accepted possession and is in full occupancy of the Premises,
     that the Lease is in full force and effect, that Tenant has received no
     notice of any default of any of its obligations under the Lease, and that
     the Lease Commencement Date is _______________________________________.

2.   That the improvements and space required to be furnished according to the
     Lease have been completed and paid for in all respects, and that to the
     best of its knowledge, Landlord has fulfilled all of its duties under the
     terms, covenants and obligations of the Lease and is not currently in
     default thereunder.

3.   That the Lease has not been modified, altered, or amended, and represents
     the entire agreement of the parties, except as follows:

     __________________________________________________________________
     __________________________________________________________________
     __________________________________________________________________
     __________________________________________________________________

4.   That there are no offsets, counterclaims or credits against rentals, nor
     have rentals been prepaid or forgiven, except as provided by the terms of
     the Lease.

                                      D-1
<PAGE>

5.   That said rental payments commenced or will commence to accrue on
     _____________, and the Lease term expires ___________________________.  The
     amount of the security deposit and all other deposits paid to Landlord is
     $__________________.

6.   That Tenant has no actual notice of a prior assignment, hypothecation or
     pledge of rents of the Lease, except: ____________________________________
     ___________________________________________________________________________
     ______________________.

7.   That this letter shall inure to your benefit and to the benefit of your
     successors and assigns, and shall be binding upon Tenant and Tenant's
     heirs, personal representatives, successors and assigns.  This letter shall
     not be deemed to alter or modify any of the terms, covenants or obligations
     of the Lease.

     The above statements are made with the understanding that you will rely on
them in connection with the purchase of the above-referenced property.

                                        Very truly yours,

                                        _______________________________________

     Date of Signature: _____________   By:____________________________________

                                      D-2
<PAGE>

                                  EXHIBIT "E"
                                  -----------

                       COST TO CONSTRUCT LEASED PREMISES
                       ---------------------------------

TENANT:   MYRIAD GENETICS, INC.

DATE: MARCH 2001

SQUARE FOOTAGE:  57,243

ITEM                                               COST ESTIMATE
----                                               -------------

l.  Building Permit                                $__________
2.  Mechanical                                     ___________
3.  Electrical                                     ___________
4.  Walls                                          ___________
5.  Doors, Frames, Hardware                        ___________
6.  Painting                                       ___________
7.  Floorcovering                                  ___________
8.  Base                                           ___________
9.  Ceiling                                        ___________
10. Glass                                          ___________
11. Exterior Blinds                                ___________
12. Millwork/Plumbing                              ___________
13. Clean Up                                       ___________
14. Contingency                                    ___________
15. Supervision                                    ___________
16. Architect                                      ___________
17. Engineer                                       ___________
18. Other                                          ___________
    Shelving                                       ___________
    Wallcovering                                   ___________
    Stain of Woodwork                              ___________

                    TOTAL COST                     $__________

                    TENANT CONSTRUCTION
                    COST OBLIGATION                $__________

                                      E-1
<PAGE>

                                  EXHIBIT "F"

                         IMPROVEMENT REMOVAL AGREEMENT
                         -----------------------------

     Landlord and Tenant agree that the following may be removed by Tenant at
end of the term, or at Landlord's election, Tenant will sell to Landlord at a
mutually agreeable price the following:

     1.   Built-in Cabinets and Lab Benches

     2.   Dark Room Door

     3.   Fume Hoods

     4.   DI Water System and Fixtures

     5.   DI Reservoir Tanks

     6.   Networking Equipment

     7.   Telephone and Computer Equipment

     8.   Lab Plumbing Fixtures Including Gas and Vacuum Connections

     9.   Projection equipment, multi-media equipment, including but not limited
          to audio visual equipment

     10.  White Boards

     Notwithstanding the above, if Tenant removes the fixtures and any walls,
ceilings, or flooring are damaged by such removal, then Tenant at Tenant's
expense shall repair the damage.

                                      F-1

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