Document:

ex10-28.htm

Exhibit 10.28

 

EXECUTION VERSION

Portions of this exhibit marked [*] are requested to be treated confidentially.

 

AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT

 

THIS AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT (this “Agreement”), dated as of August 2, 2012 (the “Restatement Date”) by and among MIDCAP FUNDING III, LLC, a Delaware limited liability company, with an office located at 7255 Woodmont Avenue, Suite 200, Bethesda, Maryland 20814 (“MidCap”), as administrative agent (“Agent”), the Lenders listed on Schedule 1 hereto and otherwise party hereto from time to time (each a “Lender”, and collectively the “Lenders”), and FURIEX PHARMACEUTICALS, INC., a Delaware corporation, APBI HOLDINGS, LLC, a North Carolina limited liability company, DEVELOPMENT PARTNERS, LLC, a Delaware limited liability company, and GENUPRO, INC., a North Carolina corporation (either individually or collectively as the context may require, the “Borrower”), provides the terms on which Lenders agree to lend to Borrower and Borrower shall repay Lenders.

 

RECITALS

 

MidCap, the Borrower and the Lenders party thereto (the “Existing Lenders”) are party to that certain Loan and Security Agreement, dated as of August 18, 2011 (the “Original Closing Date”) by and among MidCap, as Agent (the “Existing Agent”), Borrower and the Existing Lenders (as amended, restated, supplemented or otherwise modified from time to time, the “Existing Loan Agreement”) and the Existing Agent, the Borrower and the Existing Lenders wish to amend and restate the Existing Loan Agreement in its entirety with this Agreement, it being their intention that this Amended and Restated Loan Agreement and the execution and the delivery of the promissory notes and other documents or agreements executed in connection herewith shall not be a novation of the ‘Term Loan’ or ‘Term Loans’ (as such terms are defined in the Existing Loan Agreement and as used herein, collectively, the “Existing Term Loan”) and ‘Obligations’ (as defined in the Existing Loan Agreement and as used herein, including, without limitation, the Existing Term Loan, collectively, the “Existing Obligations”) of the Borrower or any Loan Party pursuant to the Existing Loan Agreement and the ‘Loan Documents’ (as such terms are defined in the Existing Loan Agreement and as used herein, the “Existing Loan Documents”), but shall merely restate and, where applicable, amend or modify the terms of such Existing Obligations, so that the Obligations (as hereinafter defined) represent, among other things, the amendment, restatement, renewal, extension and modification of the Existing Obligations and the Loan Documents (as hereinafter defined) shall restructure, restate, renew, extend, amend and modify the Existing Loan Agreement and the other Existing Loan Documents executed in connection therewith.

 

In consideration of the premises and the covenants and agreements contained herein, the parties hereto agree as follows:

 

1.           ACCOUNTING AND OTHER TERMS

 

Accounting terms not defined in this Agreement shall be construed in accordance with GAAP.  Calculations and determinations must be made in accordance with GAAP.  Capitalized terms not otherwise defined in this Agreement shall have the meanings set forth in Section 14.  All other terms contained in this Agreement, unless otherwise indicated, shall have the meaning provided by the Code to the extent such terms are defined therein.

 

2.           LOAN AND TERMS OF PAYMENT

 

2.1          Promise to Pay. Borrower hereby unconditionally promises to pay to each Lender in accordance with its respective Pro Rata Share, the outstanding principal amount of all Credit Extensions made by the Lenders, and accrued and unpaid interest thereon, and any other amounts due hereunder as and when due in accordance with this Agreement.

 

  

 

  

 

2.2           Term Loans.

 

(a)           Availability.  Subject to the terms and conditions of this Agreement, the Lenders agree, severally and not jointly, to make a  term loan to Borrower in an aggregate amount up to FORTY MILLION AND NO/100 Dollars ($40,000,000.00) according to each Lender’s Term Loan Commitment as set forth on Schedule 1 hereto (the “Term Loan”), which shall be funded as follows: (i) $30,000,000 of the Term Loan shall be funded on the Restatement Date and shall be comprised of (A) $7,500,000 from Silicon Valley Bank (representing all of its Term Loan Commitment as of the Restatement Date), (B) $10,000,000 from MidCap Funding III, LLC (representing all of its Term Loan Commitment as of the Restatement Date) and (C) $12,500,000 from Midcap Funding RE Holdings, LLC (representing a portion of its Term Loan Commitment as of the Restatement Date) (the “Initial Funding”) and (ii) $10,000,000 of the Term Loan shall be funded on August 20, 2012 by Midcap Funding RE Holdings, LLC (representing the remaining portion of its Term Loan Commitment) (such August 20, 2012 funding, the “Subsequent Funding”). For the avoidance of doubt, the Initial Funding and the Subsequent Funding shall constitute one Term Loan.  After repayment, the Term Loan may not be re-borrowed.  As of the Restatement Date, $9,729,729.72 of the Existing Term Loan outstanding under the Existing Loan Agreement shall constitute part of the Term Loan funded pursuant to the Initial Funding under this Agreement and shall constitute a portion of the Obligations.  On the Restatement Date, the Existing Term Loan shall be deemed assigned by the Existing Lenders to the Lenders hereunder as of the Restatement Date in accordance with each Lender's Pro Rata Share and in accordance with (i) Term Loan Commitment allocations as set forth on Schedule 1 hereto and (ii) Section 12.15.

 

(b)              Interest Payments and Repayment.  Commencing on the first (1st) Payment Date following the Restatement Date and continuing on the Payment Date of each successive month thereafter through and including the Maturity Date, Borrower shall make monthly payments of interest to each Lender in accordance with its respective Pro Rata Share, in arrears, and calculated as set forth in Section 2.3.  Commencing on the Amortization Date, and continuing on the Payment Date of each successive month thereafter through and including the Maturity Date, Borrower shall make consecutive monthly payments of principal to each Lender in accordance with its respective Pro Rata Share, as calculated by Agent based upon: (i) the amount of such Lender’s Term Loans, (ii) the effective rate of interest, as determined in Section 2.3, and (iii) a straight-line amortization schedule for each Credit Extension beginning on the Amortization Date and ending on the Maturity Date.  All unpaid principal and accrued interest with respect to the Term Loans is due and payable in full on the Maturity Date.  The Term Loans may be prepaid only in accordance with Sections 2.2(c) and 2.2(d).

 

(c)              Mandatory Prepayments.   If the Term Loan is accelerated following the occurrence of an Event of Default, Borrower shall immediately pay to each Lender in accordance with its respective Pro Rata Share, an amount equal to the sum of: (i) all outstanding principal of the Term Loan and all other Obligations, and all accrued and unpaid interest thereon, plus (ii) the Final Payment, plus (iii) the Prepayment Fee, plus (iv) all other sums that shall have become due and payable, including Lenders’ Expenses.

 

(d)            Permitted Prepayment of Loans.   Borrower shall have the option to prepay all, but not less than all, of the Term Loan advanced by the Lenders under this Agreement; provided, however, that Borrower (i) provides written notice to Agent of its election to prepay the Term Loan at least ten (10) days prior to such prepayment, and (ii) pays to each Lender in accordance with its respective Pro Rata Share, on the date of such prepayment, an amount equal to the sum of: (A) all outstanding principal of the Term Loan and all other Obligations, and all accrued interest thereon, plus (B) the Final Payment, plus (C) the Prepayment Fee, plus (D) all other sums that shall have become due and payable, including Lenders’ Expenses.

 

2.3           Payment of Interest on the Credit Extensions.

 

(a)           Computation of Interest.  Interest on the Credit Extensions and all fees payable hereunder shall be computed on the basis of a 360-day year and the actual number of days elapsed in the period during which such interest accrues.  In computing interest on any Credit Extension, the date of the making of such Credit Extension shall be included and the date of payment shall be excluded; provided, however, that if any Credit Extension is repaid on the same day on which it is made, such day shall be included in computing interest on such Credit Extension.

 

(b)           Interest Rate Determination.  Subject to the provisions of Section 2.3(c) below, the Term Loan

 

shall bear interest at a fixed rate on the outstanding principal amount thereof from the Funding Date for the Term Loan until paid in full at a rate per annum equal to ten percent (10%).

 

  

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(c)           Default Rate. Upon the occurrence and during the continuance of an Event of Default, at the election of the Agent or Required Lenders, Obligations shall bear interest at a rate per annum that is four percent (4.0%) above the rate that is otherwise applicable thereto (the “Default Rate”).  Any such election to apply the Default Rate by Agent or Required Lenders may, in Agent’s or Required Lenders’ sole discretion, become effective retroactively as of the date of such Event of Default having occurred.  Payment or acceptance of the increased interest rate provided in this Section 2.3(c) is not a permitted alternative to timely payment and shall not constitute a waiver of any Event of Default or otherwise prejudice or limit any rights or remedies of Agent or Lenders.

 

(d)           Debit of Accounts.  Any Lender may debit any of Borrower’s Deposit Accounts, including the Designated Deposit Account, for principal and interest payments when due or any other amounts Borrower owes the Lenders under the Loan Documents when due.  These debits shall not constitute a set-off.

 

(e)           Payments.  Payments of principal and/or interest received after 12:00 Noon Eastern Time are considered received at the opening of business on the next Business Day.  When a payment is due on a day that is not a Business Day, the payment is due the next Business Day and additional fees or interest, as applicable, shall continue to accrue until paid.  All payments to be made by Borrower hereunder or under any other Loan Document, including payments of principal and interest made hereunder and pursuant to any other Loan Document, and all fees, expenses, indemnities and reimbursements, shall be made without set-off, recoupment or counterclaim, in lawful money of the United States and in immediately available funds.  All payments required under this Agreement are to be made directly to Agent unless otherwise directed by Agent in writing.

 

(f)           Maximum Lawful Rate.  In no event shall the interest charged hereunder, with respect to the Term Loan and corresponding promissory notes (if any) or any other obligations of Borrower under any of the Loan Documents exceed the maximum amount permitted under the Laws of the State of Maryland.  Notwithstanding anything to the contrary herein or elsewhere, if at any time the rate of interest payable hereunder or under any promissory note or other Loan Document (the “Stated Rate”) would exceed the highest rate of interest permitted under any applicable Law to be charged (the “Maximum Lawful Rate”), then for so long as the Maximum Lawful Rate would be so exceeded, the rate of interest payable shall be equal to the Maximum Lawful Rate; provided, however, that if at any time thereafter the Stated Rate is less than the Maximum Lawful Rate, Borrower shall, to the extent permitted by Law, continue to pay interest at the Maximum Lawful Rate until such time as the total interest received is equal to the total interest which would have been received had the Stated Rate been (but for the operation of this provision) the interest rate payable. Thereafter, the interest rate payable shall be the Stated Rate unless and until the Stated Rate again would exceed the Maximum Lawful Rate, in which event this provision shall again apply.  In no event shall the total interest received by any Lender exceed the amount which it could lawfully have received, had the interest been calculated for the full term hereof at the Maximum Lawful Rate.  If, notwithstanding the prior sentence, any Lender has received interest hereunder in excess of the Maximum Lawful Rate, then such excess amount shall be applied to the reduction of the principal balance of such Lender’s Term Loan or to other amounts (other than interest) payable hereunder, and if no such principal or other amounts are then outstanding, such excess or part thereof remaining shall be paid to Borrower.  In computing interest payable with reference to the Maximum Lawful Rate applicable to any Lender, such interest shall be calculated at a daily rate equal to the Maximum Lawful Rate divided by the number of days in the year in which such calculation is made.

 

2.4           Fees and Expenses.  Borrower shall pay the following fees and expenses:

 

(a)           Fees under Fee Letter.  The fees payable by Borrower pursuant to the Fee Letter to the persons identified therein;

 

(b)           Final Payment.  The Final Payment, when due under Section 2.2(c) or 2.2(d), or otherwise on the Maturity Date, to each Lender, in accordance with its respective Pro Rata Share;

 

(c)           Prepayment Fee.  The Prepayment Fee, if and when due under Section 2.2(c) or 2.2(d), to each Lender, in accordance with its respective Pro Rata Share immediately prior to application of the corresponding prepayment; and

 

  

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(d)           Lenders’ Expenses.  All of Lenders’ Expenses incurred through and after the Restatement Date, when due (and in the absence of any other due date specified herein, such Lenders’ Expenses shall be due upon demand).

 

2.5           Additional Costs.  If any new Law or regulation increases a Lender’s costs or reduces its income for the Term Loan, Borrower shall pay the increase in cost or reduction in income or additional expense; provided, however, that Borrower shall not be liable for any amount attributable to any period before one hundred eighty (180) days prior to the date such Lender notifies Borrower of such increased costs.  Each Lender agrees that it shall allocate any increased costs among its customers similarly affected in good faith and in a manner consistent with such Lender’s customary practice.

 

2.6           Payments and Taxes.  Any and all payments made by Borrower under this Agreement or any other Loan Document shall be made free and clear of and without deduction for any and all present or future taxes, levies, imposts, duties, deductions, withholdings, assessments, fees or other charges imposed by any governmental authority (including any interest, additions to tax or penalties applicable thereto) other than any taxes imposed on or measured by any Lender’s overall net income and franchise taxes imposed on it (in lieu of net income taxes), by a jurisdiction (or any political subdivision thereof) as a result of any Lender being organized or resident, conducting business (other than a business deemed to arise from such Lender having executed, delivered or performed its obligations or received a payment under, or enforced, or otherwise with respect to, this Agreement or any other Loan Document) or having its principal office in such jurisdiction (“Indemnified Taxes”).  If any Indemnified Taxes shall be required by Law to be withheld or deducted from or in respect of any sum payable under this Agreement or any other Loan Document to any Lender, (a) an additional amount shall be payable as may be necessary so that, after making all required withholdings or deductions (including withholdings or deductions applicable to additional sums payable under this Section) such Lender receives an amount equal to the sum it would have received had no such withholdings or deductions been made, (b) Borrower shall make such withholdings or deductions, (c) Borrower shall pay the full amount withheld or deducted to the relevant taxing authority or other authority in accordance with applicable Law, and (d) Borrower shall deliver to such Lender evidence of such payment.  Borrower’s obligation hereunder shall survive the termination of this Agreement.

 

2.7           Secured Promissory Notes. The Term Loan shall be evidenced by one or more Secured Promissory Note(s) in substantially the form attached as Exhibit D hereto (or an amended and restated version thereto in form and substance satisfactory to Agent) (each a “Secured Promissory Note”), and shall be repayable as set forth herein.  Borrower irrevocably authorizes each Lender to make or cause to be made, on or about the Funding Date of the Term Loan or at the time of receipt of any payment of principal on such Lender’s Secured Promissory Note, an appropriate notation on such Lender’s Secured Promissory Note Record reflecting the making of such Term Loan or (as the case may be) the receipt of such payment.  The outstanding amount of the Term Loan set forth on such Lender’s Secured Promissory Note Record shall be prima facie evidence of the principal amount thereof owing and unpaid to such Lender, but the failure to record, or any error in so recording, any such amount on such Lender’s Secured Promissory Note Record shall not limit or otherwise affect the obligations of Borrower hereunder or under any Secured Promissory Note to make payments of principal of or interest on any Secured Promissory Note when due.  Upon receipt of an affidavit of an officer of a Lender as to the loss, theft, destruction, or mutilation of its Secured Promissory Note, Borrower shall issue, in lieu thereof, a replacement Secured Promissory Note in the same principal amount thereof and of like tenor.

 

3.           CONDITIONS OF LOANS

 

3.1           Conditions Precedent to the Making of the Initial Funding.  Each Lender’s obligation to fund its Term Loan Commitment is subject to the condition precedent that Agent shall consent to or shall have received, in form and substance satisfactory to Agent and Lenders, such documents, and completion of such other matters, as Agent may reasonably deem necessary or appropriate, including, without limitation:

 

(a)           duly executed original signatures to this Agreement, the Global Reaffirmation Agreement, the Fee Letter and the other Loan Documents to which Borrower is a party;

 

(b)           duly executed original Secured Promissory Notes in favor of each Lender with a face amount equal to such Lender’s Term Loan Commitment;

 

  

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(c)           the formation documents of Borrower certified by the Secretary of State of the state of organization of Borrower as of a date no earlier than thirty (30) days prior to the Restatement Date;

 

(d)           good standing certificates dated as of a date no earlier than thirty (30) days prior to the Restatement Date from each Borrower’s state of organization and each state in which the nature of Borrower’s business requires it to be qualified to transact business;

 

(e)           a duly executed original Secretary’s Certificate dated as of the Restatement Date which includes copies of the completed Borrowing Resolutions for Borrower;

 

(f)           certified copies, dated as of a recent date, of financing statement searches, as Agent shall request, accompanied by written evidence (including any UCC termination statements) that the Liens indicated in any such financing statements either constitute Permitted Liens or have been or, in connection with the funding of the Term Loan, will be terminated or released;

 

(g)           a legal opinion of Borrower’s counsel dated as of the Restatement Date together with the duly executed original signatures thereto;

 

(h)           evidence satisfactory to Agent that the insurance policies required by Section 6.5 hereof are in full force and effect, together with appropriate evidence showing loss payable and/or additional insured clauses or endorsements in favor of Agent, for the ratable benefit of Lenders;

 

(i)           payment of the fees due and owing under the Fee Letter and the Lenders’ Expenses described in Section 2.4(d);

 

(j)           timely receipt by the Agent of an executed disbursement letter;

 

(k)           the representations and warranties in Section 5 shall be true, correct and complete in all respects on the Restatement Date; provided, however, that those representations and warranties expressly referring to a specific date shall be true, accurate and complete in all respects as of such date, and no Default or Event of Default shall have occurred and be continuing or result from the making of the Term Loan.  The making of the Term Loan shall constitute Borrower’s representation, warranty and confirmation that the conditions set forth in this clause (m) have been satisfied; and;

 

(l)           in such Lender’s sole discretion, there has not been any Material Adverse Change or any material impairment in the general affairs, management, results of operation, financial condition or the prospect of repayment of the Obligations, or any material adverse deviation by Borrower from the most recent business plan of Borrower presented to and accepted by Agent.

 

3.2          Conditions to Subsequent Funding.  Midcap Funding RE Holdings, LLC’s (or its assignee’s) obligation to make the Subsequent Funding is subject to the following conditions:

 

(a)           The Initial Funding conditions shall have been satisfied and the Initial Funding shall have been made;

 

(b)           the representations and warranties in Section 5 shall be true, correct and complete in all material respects on the Restatement Date; provided, however, that such materiality qualifier shall not be applicable to any representations and warranties that already are qualified or modified by materiality in the text thereof; and provided, further that those representations and warranties expressly referring to a specific date shall be true, accurate and complete in all material respects as of such date, and no Default or Event of Default shall have occurred and be continuing or result from the making of the Subsequent Funding.  The making of the Subsequent Funding shall constitute Borrower’s representation, warranty and confirmation that the conditions set forth in this clause (b) have been satisfied; and

 

  

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(c)           in such Lender’s sole discretion, there has not been any Material Adverse Change or any material impairment in the general affairs, management, results of operation, financial condition or the prospect of repayment of the Obligations, or any material adverse deviation by Borrower from the most recent business plan of Borrower presented to and accepted by Agent.

 

3.3          Covenant to Deliver. Borrower agrees to deliver to Agent each item required to be delivered to Agent under this Agreement as a condition precedent to any Credit Extension.  Borrower expressly agrees that a Credit Extension made prior to the receipt by Agent of any such item shall not constitute a waiver by the Lenders of Borrower’s obligation to deliver such item, and any such Credit Extension in the absence of a required item shall be made in Agent’s sole discretion.

 

4.           CREATION OF SECURITY INTEREST

 

4.1          Grant of Security Interest.  Borrower hereby grants to Agent, for the ratable benefit of the Lenders, to secure the payment and performance in full of all of the Obligations, a continuing security interest in, and pledges to Agent, for the ratable benefit of the Lenders, the Collateral, wherever located, whether now owned or hereafter acquired or arising, and all proceeds and products thereof.  Borrower represents, warrants, and covenants that the security interest granted herein is and shall at all times continue to be a first priority perfected security interest in the Collateral, subject only to Permitted Liens that may have priority by operation of applicable Law.  If Borrower shall acquire a commercial tort claim (as defined in the Code), Borrower shall promptly notify Agent in a writing signed by Borrower of the general details thereof (and further details as may be reasonably required by Agent) and grant to Agent, for the ratable benefit of the Lenders, in such writing a security interest therein and in the proceeds thereof, all upon the terms of this Agreement, with such writing to be in form and substance reasonably satisfactory to Agent.

 

4.2          Authorization to File Financing Statements.  Borrower hereby authorizes Agent to file financing statements, without notice to Borrower, with all appropriate jurisdictions to perfect or protect Agent’s and each Lender’s interest or rights hereunder, including a notice that any disposition of the Collateral not permitted hereunder, by either Borrower or any other Person, shall be deemed to violate the rights of Agent and the Lenders under the Code.

 

5.           REPRESENTATIONS AND WARRANTIES

 

Borrower represents and warrants as follows at all times unless expressly provided below:

 

5.1          Due Organization, Authorization: Power and Authority.

 

(a)           Borrower and each of its Subsidiaries are duly existing and in good standing, as Registered Organizations in their respective jurisdictions of formation and are qualified and licensed to do business and are in good standing in any jurisdiction in which the conduct of their business or their ownership of property requires that they be qualified except where the failure to be so qualified could not reasonably be expected to result in a Material Adverse Change.  Borrower represents and warrants that (i) Borrower’s exact legal name is that indicated on Schedule 5.1 and on the signature page hereof; (ii) Borrower is an organization of the type and is organized in the jurisdiction set forth on Schedule 5.1; (iii) Schedule 5.1 accurately sets forth Borrower’s organizational identification number or accurately states that Borrower has none; (iv) Schedule 5.1 accurately sets forth Borrower’s place of business, or, if more than one, its chief executive office as well as Borrower’s mailing address (if different than its chief executive office); and (v) Borrower has not, in the past five (5) years, changed its jurisdiction of formation, organizational structure or type, or any organizational number assigned by its jurisdiction.  Further, in connection with the Existing Loan Agreement, Borrower delivered to Agent a completed Perfection Certificate signed by Borrower (the “Perfection Certificate”).  All information set forth on the Perfection Certificate pertaining to Borrower and each of its Subsidiaries is accurate and complete as of the Restatement Date other than with respect to changes that are reflected in the Schedules attached to this Agreement (it being understood and agreed that Borrower may from time to time update certain information in the Perfection Certificate after the Restatement Date, to the extent permitted by one or more specific provisions in this Agreement).

 

  

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(b)           The execution, delivery and performance by Borrower of the Loan Documents to which it is a party have been duly authorized, and do not (i) conflict with any of Borrower’s Operating Documents; (ii) contravene, conflict with, constitute a default under or violate any material Requirement of Law; (iii) contravene, conflict or violate any applicable order, writ, judgment, injunction, decree, determination or award of any Governmental Authority by which Borrower or any of its Subsidiaries or any of their property or assets may be bound or affected; (iv) require any action by, filing, registration, or qualification with, or Governmental Approval from, any Governmental Authority (except such Governmental Approvals which have already been obtained and are in full force and effect); or (v) constitute an event of default under any material agreement by which Borrower or any of its Subsidiaries or their respective properties is bound.  Borrower is not in default under any agreement to which it is a party or by which it is bound in which the default could reasonably be expected to have a Material Adverse Change.

 

5.2          Collateral.

 

(a)           Collateral Accounts.  Borrower has good title to, has rights in, and has the power to grant a security interest in and transfer each item of the Collateral upon which it purports to grant a Lien hereunder, free and clear of any and all Liens, except Permitted Liens.  Borrower has no Deposit Accounts, Securities Accounts, Commodity Accounts or other investment accounts other than the Collateral Accounts with the banks and/or financial institutions listed on Schedule 5.2(a), for which Borrower has given Agent notice and taken such actions as are necessary to grant to Agent, for the ratable benefit of Lenders, a perfected security interest therein.

 

(b)           Accounts.  The Accounts are bona fide, existing obligations of the Account Debtors.

 

(c)           Inventory.  All Sale Inventory is in all material respects of good and marketable quality, free from material defects.  All Development Inventory manufactured for use in and/or used in clinical trials has been synthesized in accordance with current ‘Good Manufacturing Practices’ making it suitable for use in humans.

 

(d)           Intellectual Property and License Agreements.  A list of all of Borrower’s copyrights, copyright applications, trademarks, trademark applications, patents and patent applications (“Subject Intellectual Property”) and all license agreements (including all in-bound license agreements, but excluding over-the-counter software that is commercially available to the public) is set forth on Schedule 5.2(d), which indicates, for each item of property: (i) the name of Borrower owning such Subject Intellectual Property or licensee to such license agreement; (ii) Borrower’s identifier for such property (i.e., name of patent, license, etc.), (iii) whether such property is Subject Intellectual Property (or application therefor) owned by Borrower or is property to which Borrower has rights pursuant to a license agreement, and (iv) the expiration date of such Subject Intellectual Property or license agreement.  In the case of any license agreement, Schedule 5.2(d) further indicates, for each: (A) the name and address of the licensor, (B) the name and date of the license agreement pursuant to which Intellectual Property is licensed, (C) whether or not such license agreement grants an exclusive license to Borrower, and (D) whether there are any restrictions in such license agreement as to the ability of Borrower to grant a security interest in and/or to transfer any of  its rights as a licensee under such license agreement.  Except as noted on Schedule 5.2(d), Borrower is the sole owner of its Subject Intellectual Property, except for non-exclusive licenses granted to its customers in the Ordinary Course of Business.  Each Patent is properly filed and maintained, no part of the Subject Intellectual Property has been judged invalid or unenforceable, in whole or in part, and to the best of Borrower’s knowledge (x) no claim has been made that any part of the Subject Intellectual Property violates the rights of any third party, except to the extent such claim could not reasonably be expected to result in a Material Adverse Change and (y) each Patent is valid and enforceable.

 

(e)           Location of Collateral.  On the Restatement Date, the Collateral, exclusive of Development Inventory, is located at the address(es) identified on Schedule 5.2(e), and is not in the possession of any third party bailee (such as a warehouse) except as disclosed Schedule 5.2(e), and as of the Restatement Date, no such third party bailee possesses components of the Collateral, exclusive of Development Inventory, in excess of [*] Dollars ($[*]) or which constitutes Borrowers’ Books.  None of the components of the Collateral, other than Development Inventory, shall be maintained at locations other than as disclosed Schedule 5.2(e) on the Restatement Date or as permitted pursuant to Section 7.2.  In the event that Borrower, after the Restatement Date, intends to store or otherwise deliver any portion of the Collateral, other than Development Inventory, to a bailee in excess of [*] Dollars ($[*]) or which constitutes Borrowers’ Books, then Borrower will first receive the written consent of Agent and such bailee must execute and deliver a bailee agreement in form and substance satisfactory to Agent in its sole discretion.  Without limiting the foregoing, in the event that (x) PPD is in default under its lease for the premises located at 3900 Paramount Parkway, Suite 150, Morrisville, North Carolina 27560 or (y) such lease is terminated and Borrower enters into a new or separate lease with the owner of such premises or if the owner confirms Borrower’s sublease shall remain in effect, then in either case of (x) or (y), upon the request of Agent, Borrower shall obtain an Access Agreement executed by such owner and by Borrower in favor of Agent.

 

[*] Confidential treatment requested; certain information omitted and filed separately with the SEC.

 

  

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5.3           Litigation.  Except for routine proceedings (which shall not include any enforcement action or other adverse proceedings) with the FDA or other similar regulatory agencies, or as otherwise disclosed on Schedule 5.3 hereto, there are no actions or proceedings pending or, to the knowledge of the Responsible Officers, threatened in writing by or against Borrower or any of its Subsidiaries involving more than [*] Dollars ($[*]).

 

5.4           No Material Deterioration in Financial Condition; Financial Statements.  All consolidated financial statements for Borrower and any of its Subsidiaries delivered to Agent fairly present, in conformity with GAAP, in all material respects Borrower’s consolidated financial condition and Borrower’s consolidated results of operations; provided, however, the interim financial statements of Borrower lack footnotes and are subject to year-end audit adjustments, all in accordance with GAAP .  There has not been any material deterioration in Borrower’s consolidated financial condition since the date of the most recent financial statements and projections submitted to Agent.

 

5.5           Solvency.  The fair salable value of Borrower’s assets (including goodwill minus disposition costs) exceeds the fair value of its liabilities.  After giving effect to the transactions described in this Agreement, (a) Borrower is not left with unreasonably small capital in relation to its business as presently conducted, and (b) Borrower is able to pay its debts (including trade debts) as they mature.

 

5.6           Regulatory Compliance.

 

(a)         Borrower is not an “investment company” or a company “controlled” by an “investment company” under the Investment Company Act of 1940, as amended.  Borrower is not engaged as one of its important activities in extending credit for margin stock (under Regulations X, T and U of the Federal Reserve Board of Governors).  Borrower has complied in all material respects with the Federal Fair Labor Standards Act.  Neither Borrower nor any of its Subsidiaries is a “holding company” or an “affiliate” of a “holding company” or a “subsidiary company” of a “holding company”, as each term is defined and used in the Public Utility Holding Company Act of 2005.  Borrower has not violated any Laws, ordinances or rules, the violation of which could reasonably be expected to have a Material Adverse Change.  None of Borrower’s or any of its Subsidiaries’ properties or assets has been used by Borrower or any Subsidiary or, to Borrower’s knowledge, by previous Persons, in disposing, producing, storing, treating, or transporting any hazardous substance other than in material compliance with applicable Laws.  Borrower has obtained all Required Permits, or has contracted with third parties holding Required Permits, necessary for compliance with all Laws and all such Required Permits are current.  Borrower and each of its Subsidiaries have obtained all consents, approvals and authorizations of, made all declarations or filings with, and given all notices to, all Governmental Authorities that are necessary to continue their respective businesses as currently conducted.

 

(b)         None of the Borrower, its Affiliates or any of their respective agents acting or benefiting

 

in any capacity in connection with the transactions contemplated by this Agreement is (i) in violation of any Anti-Terrorism Law, (ii) engages in or conspires to engage in any transaction that evades or avoids, or has the purpose of evading or avoiding or attempts to violate, any of the prohibitions set forth in any Anti-Terrorism Law, or (iii) is a Blocked Person.  Neither Borrower nor, to the knowledge of Borrower, any of its Affiliates or agents acting or benefiting in any capacity in connection with the transactions contemplated by this Agreement, (x) conducts any business or engages in making or receiving any contribution of funds, goods or services to or for the benefit of any Blocked Person, or (y) deals in, or otherwise engages in any transaction relating to, any property or interest in property blocked pursuant to Executive Order No. 13224, any similar executive order or other Anti-Terrorism Law.

 

[*] Confidential treatment requested; certain information omitted and filed separately with the SEC.

 

  

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5.7           Subsidiaries; Investments.  Borrower does not own any stock, partnership interest or other equity securities, except for Permitted Investments.

 

5.8           Tax Returns and Payments; Pension Contributions.  Borrower has timely filed all required tax returns and reports, and Borrower and its Subsidiaries have timely paid all foreign, federal, state and local taxes, assessments, deposits and contributions owed by Borrower, except that Borrower may defer payment of any contested taxes so long as Borrower (a) in good faith contests its obligation to pay such taxes by appropriate proceedings promptly and diligently instituted and conducted, (b) notifies Agent in writing of the commencement of, and any material development in, the proceedings, and (c) posts bonds or takes any other steps required to prevent the governmental authority levying such contested taxes from obtaining a Lien upon any of the Collateral that is other than a “Permitted Lien”.  Borrower is unaware of any claims or adjustments proposed for any of Borrower’s prior tax years which could result in additional taxes becoming due and payable by Borrower.  Borrower has paid all amounts required to fund all of its present pension, profit sharing and deferred compensation plans in accordance with their terms, and Borrower has not withdrawn from participation in, and has not permitted partial or complete termination of, or permitted the occurrence of any other event with respect to, any such plan which could reasonably be expected to result in any liability of Borrower, including any liability to the Pension Benefit Guaranty Corporation or its successors or any other governmental agency.

 

5.9            Use of Proceeds.  Borrower shall use the proceeds of the Credit Extensions solely as working capital and to fund its general business requirements, and not for personal, family, household or agricultural purposes.

 

5.10          Full Disclosure.  No written representation, warranty or other statement of Borrower in any certificate or written statement given to Agent or any Lender, as of the date such representation, warranty, or other statement was made, taken together with all such written certificates and written statements given to Agent or any Lender, contains any untrue statement of a material fact or omits to state a material fact necessary to make the statements contained in the certificates or statements not misleading (it being recognized that the projections and forecasts provided by Borrower in good faith and based upon reasonable assumptions are not viewed as facts and that actual results during the period or periods covered by such projections and forecasts may differ from the projected or forecasted results).

 

5.11          Regulatory Developments.

 

(a)           All Products and all Required Permits are listed on Schedule 5.11 (as updated from time to time pursuant to Section 6.2(e)), and Borrower has delivered to Agent a copy of all Required Permits as of the date hereof and to the extent requested by Agent pursuant to Section 6.2(e).

 

(b)           Without limiting the generality of Section 5.6 above, with respect to any Development Compound or Sale Compound of Borrower,  Borrower has received and such Product is the subject of, all Required Permits needed in connection with the testing and/or manufacture, as applicable, with respect to such Product as such testing is currently being conducted by or on behalf of Borrower with respect to Development Compounds or Sale Compounds, and Borrower has not received any notice from any applicable Governmental Authority, specifically including the FDA, that such Governmental Authority is conducting an investigation or review of (i) Borrower’s manufacturing facilities and processes for any Sale Compound which have disclosed any material deficiencies or violations of Laws and/or the Required Permits related to the manufacture of such Sale Compound, or (ii) any such Required Permit or that any such Required Permit has been revoked or withdrawn, nor has any such Governmental Authority issued any order or recommendation stating that the testing of such Development Compound or manufacturing of such Sale Compound by Borrower should cease.

 

(c)         Without limiting the generality of Section 5.6 above, with respect to any Sale Compound that may be marketed or sold by Borrower, Borrower has received, and such Sale Compound is the subject of, all Required Permits needed in connection with the marketing and sales of such Sale Compound that may be marketed or sold by Borrower, and Borrower has not received any notice from any applicable Governmental Authority, specifically including the FDA, that such Governmental Authority is conducting an investigation or review of any such Required Permit or approval or that any such Required Permit has been revoked or withdrawn, nor has any such Governmental Authority issued any order or recommendation stating that such marketing or sales of such Sale Compound cease or that such Sale Compound be withdrawn from the marketplace.

 

  

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(d)         Without limiting the generality of Section 5.6 above, there have been no serious adverse clinical test results related to the safety or efficacy of Development Compounds resulting in the termination of all clinical studies for such Development Compound or recalls of Sale Compounds (whether voluntary or involuntary), in each case which have resulted in or could reasonably be expected to result in a Material Adverse Change.

 

(e)         Borrower has not experienced any material failures in its manufacturing of any Sale Compound such that the amount of such Sale Compound successfully manufactured by Borrower in accordance with all specifications thereof and the required payments related thereto in any month shall decrease significantly with respect to the quantities of such Sale Compound produced in the prior month, which such decrease has resulted in or could reasonably be expected to result in a Material Adverse Change.

 

6.           AFFIRMATIVE COVENANTS

 

Borrower covenants and agrees to do all of the following:

 

6.1          Organization and Existence; Government Compliance.

 

(a)           Maintain its and all its Subsidiaries’ legal existence and good standing in their respective jurisdictions of formation and maintain qualification in each jurisdiction in which the failure to so qualify could reasonably be expected to result in a Material Adverse Change.  Borrower shall comply, and have each Subsidiary comply, with all Laws, ordinances and regulations to which it is subject, the noncompliance with which could reasonably be expected to result in a Material Adverse Change.

 

(b)           Obtain and keep in full force and effect, all of the Governmental Approvals, if any, necessary for the performance by Borrower of its obligations under the Loan Documents to which it is a party and the grant of a security interest to Agent for the ratable benefit of the Lenders, in all of the Collateral.  Borrower shall promptly provide copies of any such obtained Governmental Approvals to Agent.

 

(c)           In connection with the testing of each Development Compound or the manufacture, marketing or sale of each and any Sale Compound by Borrower, Borrower shall comply fully and completely in all respects with all Required Permits at all times issued by any Governmental Authority the noncompliance with which could reasonably be expected to result in a Material Adverse Change, specifically including the FDA, with respect to such testing of any Development Compound or such manufacture, marketing or sales of any Sale Compound by Borrower as such activities are at any such time being conducted by Borrower.

 

6.2          Financial Statements, Reports, Certificates.

 

(a)           Deliver to Agent: (i) as soon as available, but no later than forty-five (45) days after the last day of each month, a company prepared consolidated balance sheet, income statement and cash flow statement covering Borrower’s consolidated operations for such month certified by a Responsible Officer and in a form reasonably acceptable to Agent; (ii) as soon as available, but no later than one hundred fifty (150) days after the last day of Borrower’s fiscal year, audited consolidated financial statements prepared under GAAP, consistently applied, together with an unqualified opinion on the financial statements from an independent certified public accounting firm acceptable to Agent in its reasonable discretion; (iii) as soon as available after approval thereof by Borrower’s Board of Directors, but no later than ninety (90) days after the last day of Borrower’s fiscal year, Borrower’s financial projections for the current fiscal year as approved by Borrower’s Board of Directors, which shall reflect financial projections on no less than a quarterly basis; (iv) other than with respect to reports made available in accordance with clause (v), below, within five (5) days of delivery, copies of all statements, reports and notices made available to all of Borrower’s security holders; (v) so long as Borrower is subject to the reporting requirements under the Securities Exchange Act of 1934, as amended, within five (5) days of filing, all reports on Form 10-K, 10-Q and 8-K filed with the Securities and Exchange Commission or a link thereto on Borrower’s or another website on the Internet; (vi) a prompt report of any legal actions pending or threatened against Borrower or any of its Subsidiaries that could be reasonably expected to result in damages or costs to Borrower or any of its Subsidiaries of [*] Dollars ($[*]) or more or could result in a Material Adverse Change; and (vii) budgets, sales projections, operating plans and other financial information reasonably requested by Agent.

 

[*] Confidential treatment requested; certain information omitted and filed separately with the SEC.

 

  

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(b)           Within forty-five (45) days after the last day of each month, deliver to Agent with the monthly financial statements described above, a duly completed Compliance Certificate signed by a Responsible Officer.

 

(c)           Keep proper books of record and account in accordance with GAAP in which full, true and correct entries shall be made of all dealings and transactions in relation to its business and activities.  Borrower shall allow, at the sole cost of Borrower, Agent and Lenders to visit and inspect (such visit or inspection to be during normal business hours so long as no Default or Event of Default exists) any of its properties, to examine and make abstracts or copies from any of Borrower’s books and records, to conduct a collateral audit and analysis of its operations and the Collateral to verify the amount and age of the Accounts, the identity and credit of the respective Account Debtors, to review the billing practices of Borrower and to discuss its respective affairs, finances and accounts with their respective officers, employees and independent public accountants as often as may reasonably be desired.  Notwithstanding the foregoing, such audits shall be conducted at Borrower’s expense no more often than once every twelve (12) months unless a Default or Event of Default has occurred and is continuing.

 

(d)           Within thirty (30) days of (i) acquiring and/or obtaining any new Subject Intellectual Property, or (ii) enters into or becomes bound by any additional license agreement (other than products that are commercially available to the public), or upon any material change in Borrower’s existing Subject Intellectual Property, deliver to Agent an updated Schedule 5.2(d) reflecting same.  Borrower shall use its commercially reasonable efforts to obtain the consent of, or waiver by, any person whose consent or waiver is necessary for (x) all licenses or agreements to be deemed “Collateral” and for Agent to have a security interest in it that might otherwise be restricted or prohibited by Law or by the terms of any such license or agreement, whether now existing or entered into in the future, and (y) Agent to have the ability in the event of a liquidation of any Collateral to dispose of such Collateral in accordance with Agent’s rights and remedies under this Agreement and the other Loan Documents.

 

(e)           If, after the Restatement Date, Borrower determines to manufacture, sell or market any new Sale Compound, Borrower shall give prior written notice to Agent of such determination (which shall include a brief description of such Sale Compound, plus a list of all Required Permits relating to such new Sale Compound  (and a copy of such Required Permits if requested by Agent), along with a copy of an updated Schedule 5.11; provided, however, that if Borrower shall at any time obtain any new or additional Required Permits from the FDA, DEA, or parallel state or local authorities, or foreign counterparts of the FDA, DEA, or parallel state or local authorities, with respect to any Product which has previously been disclosed to Agent, Borrower shall promptly give written notice to Agent of such new or additional Required Permits (along with a copy thereof if requested by Agent).

 

6.3             Inventory; Returns.  Keep all Sale Inventory in good and marketable condition, free from material defects and keep all Development Inventory manufactured for use in and/or used in clinical trials synthesized in accordance with current ‘Good Manufacturing Practices’ and suitable for use in humans.  Returns and allowances between Borrower and its Account Debtors shall follow such customary practices as may be established by Borrower and consistent with industry practice if it engages in the sale of Sale Inventory. Borrower must promptly notify Agent of all returns, recoveries, disputes and claims with respect to Sale Inventory that involve more than [*] Dollars ($[*]).

 

6.4          Taxes; Pensions.  Timely file and require each of its Subsidiaries to timely file, all required tax returns and reports and timely pay, and require each of its Subsidiaries to timely file, all foreign, federal, state, and local taxes, assessments, deposits and contributions owed by Borrower and each of its Subsidiaries, except for deferred payment of any taxes contested pursuant to the terms of Section 5.8 hereof, and shall deliver to Agent, on demand, appropriate certificates attesting to such payments, and pay all amounts necessary to fund all present pension, profit sharing and deferred compensation plans in accordance with their terms.

 

[*] Confidential treatment requested; certain information omitted and filed separately with the SEC.

 

  

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6.5          Insurance.  Keep its business and the Collateral insured for risks and in amounts standard for companies in Borrower’s industry and location and as Agent may reasonably request.  Insurance policies shall be in a form, with companies, and in amounts that are reasonably satisfactory to Agent.  All property policies shall have a lender’s loss payable endorsement showing Agent as lender loss payee and waive subrogation against Agent, and all liability policies shall show, or have endorsements showing, Agent, as an additional insured.  All policies (or the loss payable and additional insured endorsements) shall provide that the insurer shall endeavor to give Agent at least thirty (30) days notice before canceling, amending, or declining to renew its policy.  At Agent’s request, Borrower shall deliver certified copies of policies and evidence of all premium payments.  Proceeds payable under any policy shall, at Agent’s option, be payable to Agent on behalf of the Lenders on account of the Obligations.  If Borrower fails to obtain insurance as required under this Section 6.5 or to pay any amount or furnish any required proof of payment to third persons and Agent, Agent may make all or part of such payment or obtain such insurance policies required in this Section 6.5, and take any action under the policies Agent deems prudent.

 

6.6         Operating Accounts.

 

(a)             Except for those Collateral Accounts listed on Schedule 5.2(a), maintain all of its, and all of its Subsidiaries’, operating and other Deposit Accounts, Securities Accounts, Investment Accounts and Commodity Accounts with Silicon Valley Bank or its affiliates, as applicable, which operating and other Deposit Accounts, Securities Accounts, Investment Accounts and Commodity Accounts with Silicon Valley Bank or its affiliates shall contain no less than fifty percent (50%) of Borrower’s total cash and Cash Equivalents.

 

(b)            Provide Agent five (5) days prior written notice before establishing any Collateral Account at or with any bank or financial institution.  In addition, for each Collateral Account that Borrower at any time maintains, Borrower shall cause the applicable bank or financial institution at or with which any Collateral Account is maintained to execute and deliver a Control Agreement or other appropriate instrument with respect to such Collateral Account to perfect Agent’s Lien in such Collateral Account in accordance with the terms hereunder, which Control Agreement may not be terminated without prior written consent of Agent.  The provisions of the previous sentence shall not apply to deposit accounts exclusively used for payroll, payroll taxes and other employee wage and benefit payments to or for the benefit of Borrower’s employees and identified to Agent by Borrower as such.

 

6.7        Protection of Intellectual Property Rights.  Borrower shall own, or be licensed to use or otherwise have the right to use, all Material Intellectual Property.  All Subject Intellectual Property of Borrower is and shall be protected and/or duly and properly registered, filed or issued in the appropriate office and jurisdictions for such registrations, filings or issuances, all in a manner consistent with industry standards for similar businesses except where the failure to do so would not reasonably be expected to result in a Material Adverse Change.  Borrower shall not become a party to, nor become bound by, any material license or similar agreement with respect to which Borrower is the licensee thereunder that prohibits or otherwise restricts Borrower from granting a security interest in Borrower’s rights under such license agreement.  Borrower shall at all times conduct its business without knowingly committing infringement of any Intellectual Property rights of others.  Borrower shall, to the extent it determines, in the exercise of its reasonable business judgment, that it is prudent to do the following: (a) protect, defend and maintain the validity and enforceability of its Intellectual Property; (b) promptly advise Agent in writing of material infringements of its Intellectual Property; and (c) not allow any Material Intellectual Property to be abandoned, forfeited or dedicated to the public without Agent’s prior written consent.  If Borrower (i) obtains any patent, registered trademark or servicemark, registered copyright, registered mask work, or any pending application for any of the foregoing, whether as owner, licensee or otherwise, or (ii) applies for any patent or the registration of any trademark or servicemark, then Borrower shall concurrently provide written notice thereof to Agent in accordance with Section 6.2(d) and concurrently with such notice, shall provide to Agent copies of all applications that it filed for patents or for the registration of trademarks, servicemarks, copyrights or mask works.

 

6.8        Litigation Cooperation.  From the date hereof and continuing through the termination of this Agreement, make available to Agent, without expense to Agent, Borrower and its officers, employees and agents and Borrower’s Books, to the extent that Agent may deem them reasonably necessary to prosecute or defend any third-party suit or proceeding instituted by or against Agent with respect to any Collateral or relating to Borrower.

 

  

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6.9        Notices of Litigation and Default.  Borrower will give prompt written notice to Agent of any litigation or governmental proceedings pending or threatened (in writing) against Borrower which would reasonably be expected to result in a Material Adverse Change.  Without limiting or contradicting any other more specific provision of this Agreement, promptly (and in any event within three (3) Business Days) upon Borrower becoming aware of the existence of any Event of Default or event which, with the giving of notice or passage of time, or both, would constitute an Event of Default, Borrower shall give written notice to Agent of such occurrence, which such notice shall include a reasonably detailed description of such Event of Default or event which, with the giving of notice or passage of time, or both, would constitute an Event of Default.

 

6.10      Creation/Acquisition of Subsidiaries.  In the event Borrower or any Subsidiary creates or acquires any Subsidiary, Borrower and such Subsidiary shall promptly notify Agent of the creation or acquisition of such new Subsidiary and take all such action as may be reasonably required by Agent to cause each such domestic Subsidiary to become a co-Borrower hereunder or to guarantee the Obligations of Borrower under the Loan Documents and, in each case,  grant a continuing pledge and security interest in and to the assets of such Subsidiary (substantially as described on Exhibit A hereto); and Borrower shall grant and pledge to Agent, for the ratable benefit of the Lenders, a perfected security interest in the stock, units or other evidence of ownership of each Subsidiary.

 

6.11      Financial Covenant.  Borrower shall maintain at all times unrestricted cash and unrestricted Cash Equivalents on hand in Collateral Accounts maintained at Silicon Valley Bank or its affiliates and subject to a Control Agreement of not less than (a) $7,500,000 through and including the second anniversary of the Restatement Date, (b) $5,000,000 through and including the third anniversary of the Restatement Date and (c) $2,500,000 thereafter.

 

6.12      Nesina Royalties.  Borrower shall at all times maintain the right to receive (a) royalty payments of at least [*] percent ([*]%) of the Nesina Japan Sales and (b) all such other royalty and milestone payments (other than as described in clause (a) of this Section 6.12) under and pursuant to the Nesina License Agreement as in effect on the Restatement Date without giving effect to any future amendments, restatements, supplements or other modifications thereto.

 

6.13      Further Assurances.

 

(a)            Execute any further instruments and take further action as Agent reasonably requests to perfect or continue Agent’s Lien in the Collateral or to effect the purposes of this Agreement.

 

(b)           Deliver to Agent, within five (5) days after the same are sent or received, copies of all material correspondence, reports, documents and other filings with any Governmental Authority that could reasonably be expected to have a material adverse effect on any of the Governmental Approvals material to Borrower’s business or otherwise result in a Material Adverse Change.

 

6.14     Post-Closing Obligations.  Borrowers shall complete each of the post closing obligations and/or deliver to Agent each of the documents, instruments, agreements and information listed on Schedule 6.14 attached hereto, on or before the date set forth for each such item thereon, each of which shall be completed or provided in form and substance satisfactory to Agent and Lenders.

 

7.            NEGATIVE COVENANTS

 

Borrower shall not do any of the following without the prior written consent of Agent and Required Lenders:

 

[*] Confidential treatment requested; certain information omitted and filed separately with the SEC.

 

  

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7.1       Dispositions.  Convey, sell, lease, transfer, assign, grant a security in or otherwise dispose of (collectively, “Transfer”), or permit any of its Subsidiaries to Transfer, all or any part of its business or property, except for (a) the sale, lease or disposition of Inventory in the Ordinary Course of Business; (b) the sale, lease or disposition of worn-out or obsolete Equipment; (c) the payment of cash or Cash Equivalents in the Ordinary Course of Business solely for the payment of costs and expenses associated with operation of Borrower’s business, including without limitation expenditures relating to (i) Borrower’s Phase I, Phase II and Phase III development activities and (ii) the acquisition (including in-licensing) of additional compounds so long as immediately after any such acquisition Borrower [*] based on the financial projections delivered to Agent; (d)  transfers of Intellectual Property pursuant to outbound license agreements with third parties in the Ordinary Course of Business so long as (i) Borrower receives not less than $[*] of net cash payments from each such license agreement that grants rights with respect to the US market or globally which such amounts have been fully-earned and are non-refundable at the time such license agreement is consummated and (ii) at all times Borrower shall have rights necessary to receive future milestone and royalty payments for at least two of Borrower’s existing Products (“Permitted IP Dispositions”); (e) in connection with Permitted Liens; or (f) the [*] Permitted Transfer. Without limiting the foregoing, Borrower agrees that it shall not grant a security interest or otherwise encumber any of its Intellectual Property without Agent’s and Required Lenders’ prior written consent.

 

7.2        Changes in Business, Management, Ownership or Business Locations.  (a) Other than the manufacture, marketing and sale of Sale Inventory, engage in or permit any of its Subsidiaries to engage in any business other than the businesses currently engaged in by Borrower and such Subsidiary, as applicable, or reasonably related thereto; (b) liquidate or dissolve; (c) (i) (A) have a change in any Responsible Officer position that does not result in a qualified replacement or (B) the failure to fill a vacancy with respect to any Responsible Officer position with a suitable qualified replacement within (60) days following such vacancy, or (ii) enter into any transaction or series of related transactions which would constitute or cause a Change of Control; or (d) add any new offices or business locations, including warehouses (where such new offices or business locations contain more than [*] Dollars ($[*]) in Borrower’s assets or property or any of Borrowers’ Books unless, prior to the addition of such new office, business location or warehouse, Borrower obtains an Access Agreement executed by the owner of such premises and Borrower in favor of agent (e) change its jurisdiction of organization; (f) other than the creation or acquisition of Subsidiaries in accordance with and subject to the conditions set forth in Section 6.10 of this Agreement, change its organizational structure or type; (g) change its legal name; or (h) change any organizational number (if any) assigned by its jurisdiction of organization.

 

7.3        Mergers or Acquisitions.  Merge or consolidate, or permit any of its Subsidiaries to merge or consolidate, with any other Person, or acquire, or permit any of its Subsidiaries to acquire, all or substantially all of the capital stock or property of another Person; provided, however, that a Subsidiary of Borrower may merge or consolidate into another Subsidiary that is a Loan Party or into Borrower, so long as (a) Borrower has provided Agent with prior written notice of such transaction, (b) Borrower shall be the surviving legal entity, (c) Borrower’s tangible net worth is not thereby reduced, and (d) as long as no Event of Default is occurring prior thereto or arises as a result therefrom.

 

7.4        Indebtedness.  Create, incur, assume, or be liable for any Indebtedness, or permit any Subsidiary to do so, other than Permitted Indebtedness.

 

7.5        Encumbrance.  (a) Create, incur, allow, or suffer any Lien on any of its property, or assign or convey any right to receive income, including the sale of any Accounts, or permit any of its Subsidiaries to do so, except for Permitted Liens, (b) permit any Collateral not to be subject to the first priority security interest granted herein, or (c) enter into any agreement, document, instrument or other arrangement (except with or in favor of Agent) with any Person which directly or indirectly prohibits or has the effect of prohibiting Borrower or any Subsidiary from collaterally assigning, mortgaging, pledging, granting a security interest in or Lien upon any of Borrower’s or any Subsidiary’s property (including, without limitation, Intellectual Property), all of the foregoing except as is otherwise permitted in Section 7.1 hereof and the definition of “Permitted Liens” herein.

 

7.6        Maintenance of Collateral Accounts.  Maintain any Collateral Account, except pursuant to the terms of Section 6.6(b) hereof.

 

7.7        Distributions; Investments.  (a) Pay any dividends (other than dividends payable solely in common stock) or make any distribution or payment on or redeem, retire or purchase any capital stock (other than repurchases pursuant to the terms of employee stock purchase plans, employee restricted stock agreements or similar plans), or (b) directly or indirectly make any Investment other than Permitted Investments, or permit any of its Subsidiaries to do so.

 

[*] Confidential treatment requested; certain information omitted and filed separately with the SEC.

 

  

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7.8        Transactions with Affiliates.  Directly or indirectly enter into or permit to exist any material transaction with any Affiliate of Borrower, except for transactions that are in the Ordinary Course of Business, upon fair and reasonable terms that are no less favorable to Borrower than would be obtained in an arm’s length transaction with a non-affiliated Person.

 

7.9        [Reserved].

 

7.10      Compliance.  Become an “investment company” or a company controlled by an “investment company”, under the Investment Company Act of 1940, as amended or undertake as one of its important activities extending credit to purchase or carry margin stock (as defined in Regulation U of the Board of Governors of the Federal Reserve System), or use the proceeds of any Credit Extension for that purpose; fail to meet the minimum funding requirements of ERISA, permit a Reportable Event or Prohibited Transaction, as defined in ERISA, to occur; fail to comply with the Federal Fair Labor Standards Act or violate any other Law or regulation, if the violation could reasonably be expected to result in a Material Adverse Change, or permit any of its Subsidiaries to do so; withdraw or permit any Subsidiary to withdraw from participation in, permit partial or complete termination of, or permit the occurrence of any other event with respect to, any present pension, profit sharing and deferred compensation plan which could reasonably be expected to result in any liability of Borrower, including any liability to the Pension Benefit Guaranty Corporation or its successors or any other governmental agency.

 

7.11      Compliance with Anti-Terrorism Laws.  Agent hereby notifies Borrower that pursuant to the requirements of Anti-Terrorism Laws, and Agent’s policies and practices, Agent is required to obtain, verify and record certain information and documentation that identifies Borrower and its principals, which information includes the name and address of Borrower and its principals and such other information that will allow Agent to identify such party in accordance with Anti-Terrorism Laws.  Borrower will not, nor will Borrower permit any Subsidiary or Affiliate to, directly or indirectly, knowingly enter into any documents, instruments, agreements or contracts with any Person listed on the OFAC Lists.  Borrower shall immediately notify Agent if Borrower has knowledge that Borrower or any Subsidiary or Affiliate is listed on the OFAC Lists or (a) is convicted on, (b) pleads nolo contendere to, (c) is indicted on, or (d) is arraigned and held over on charges involving money laundering or predicate crimes to money laundering.  Borrower will not, nor will Borrower permit any Subsidiary or Affiliate to, directly or indirectly, (i) conduct any business or engage in any transaction or dealing with any Blocked Person, including, without limitation, the making or receiving of any contribution of funds, goods or services to or for the benefit of any Blocked Person, (ii) deal in, or otherwise engage in any transaction relating to, any property or interests in property blocked pursuant to Executive Order No. 13224, any similar executive order or other Anti-Terrorism Law, or (iii) engage in or conspire to engage in any transaction that evades or avoids, or has the purpose of evading or avoiding, or attempts to violate, any of the prohibitions set forth in Executive Order No. 13224 or other Anti-Terrorism Law.

 

8.           EVENTS OF DEFAULT

 

Any one of the following shall constitute an event of default (an “Event of Default”) under this Agreement:

 

8.1     Payment Default.  Borrower fails to (a) make any payment of principal or interest on any Credit Extension on its due date, or (b) pay any other Obligations within three (3) Business Days after such Obligations are due and payable (which three (3) Business Day grace period shall not apply to payments due on the Maturity Date or the date of acceleration pursuant to Section 9.1 (a) hereof).  During the cure period, the failure to cure the payment default is not an Event of Default (but no Credit Extension will be made during the cure period);

 

  

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8.2          Covenant Default.

 

(a)           Borrower fails or neglects to perform any obligation in Sections 6.1(c), 6.2, 6.4, 6.5, 6.6, 6.7, 6.10, 6.11, 6.12, 6.13 or 6.14 or violates any covenant in Section 7; or

 

(b)           Borrower or any of its Subsidiaries fails or neglects to perform, keep, or observe any other term, provision, condition, covenant or agreement contained in this Agreement or any Loan Documents, and as to any default (other than those specified in this Section 8) under such other term, provision, condition, covenant or agreement that can be cured, has failed to cure the default within twenty (20) days after the occurrence thereof; provided, however, that if the default cannot by its nature be cured within the twenty (20) day period or cannot after diligent attempts by Borrower be cured within such twenty (20) day period, and such default is likely to be cured within a reasonable time, then Borrower shall have an additional period (which shall not in any case exceed thirty (30) days) to attempt to cure such default, and within such reasonable time period the failure to cure the default shall not be deemed an Event of Default (but no Credit Extensions shall be made during such cure period).  Grace periods provided under this Section shall not apply, among other things, to any covenant set forth in subsection (a) above;

 

8.3          Material Adverse Change.  A Material Adverse Change occurs;

 

8.4          Attachment; Levy; Restraint on Business.

 

(a)           (i) The service of process seeking to attach, by trustee or similar process, any funds of Borrower or of any entity under control of Borrower (including a Subsidiary) on deposit with the Lenders or any Lender Affiliate, or (ii) a notice of lien, levy, or assessment is filed against any of Borrower’s assets by any government agency, and the same under subclauses (i) and (ii) hereof are not, within ten (10) days after the occurrence thereof, discharged or stayed (whether through the posting of a bond or otherwise); provided, however, no Credit Extensions shall be made during any ten (10) day cure period; and

 

(b)           (i) any material portion of Borrower’s assets is attached, seized, levied on, or comes into possession of a trustee or receiver, or (ii) any court order enjoins, restrains, or prevents Borrower from conducting any material portion of its business;

 

8.5           Insolvency.  (a) Borrower is unable to pay its debts (including trade debts) as they become due or otherwise becomes insolvent; (b) Borrower begins an Insolvency Proceeding; or (c) an Insolvency Proceeding is begun against Borrower and not dismissed or stayed within thirty (30) days (but no Credit Extensions shall be made while any of the conditions described in clause (a) exist and/or until any Insolvency Proceeding is dismissed);

 

8.6           Other Agreements.  There is a default in any agreement to which Borrower is a party with a third party or parties resulting in a right by such third party or parties, whether or not exercised, to accelerate the maturity of any Indebtedness in an amount in excess of Two Hundred Fifty Thousand Dollars ($250,000) or that could reasonably be expected to result in a Material Adverse Change and such default has not been waived in writing by such third party or parties;

 

8.7           Judgments.  One or more judgments, orders, or decrees  for the payment of money in an amount, individually or in the aggregate, of at least One Hundred Thousand Dollars ($100,000) (not covered by independent third-party insurance as to which liability has been accepted by such insurance carrier) shall be rendered against Borrower and shall remain unsatisfied, unvacated, or unstayed for a period of fifteen (15) days after the entry thereof, provided, however, that no Credit Extensions will be made prior to the satisfaction, vacation, or stay of such judgment, order or decree;

 

8.8           Misrepresentations.  Borrower or any Person acting for Borrower makes any representation, warranty, or other statement now or later in this Agreement, any Loan Document or in any writing delivered to Agent and/or the Lenders or to induce Agent and/or the Lenders to enter this Agreement or any Loan Document, and such representation, warranty, or other statement is incorrect in any material respect when made;

 

8.9           [Reserved];

 

  

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8.10           Governmental Approvals.  Any Governmental Approval shall have been (a) revoked, rescinded, suspended, modified in an adverse manner or not renewed in the Ordinary Course of Business for a full term, or (b) subject to any decision by a Governmental Authority that designates a hearing with respect to any applications for renewal of any of such Governmental Approval or that could result in the Governmental Authority taking any of the actions described in clause (a) above, and such decision or such revocation, rescission, suspension, modification or non-renewal (i) has resulted in, or could reasonably be expected to result in, a Material Adverse Change, or (ii) adversely affects the legal qualifications of Borrower or any of its Subsidiaries to hold such Governmental Approval in any applicable jurisdiction and such revocation, rescission, suspension, modification or non-renewal could reasonably be expected to affect the status of or legal qualifications of Borrower or any of its Subsidiaries to hold any Governmental Approval in any other jurisdiction;

 

8.11           Criminal Proceeding.  The institution by any Governmental Authority of criminal proceedings against Borrower either (a) involving fraud, moral turpitude, or a felony, or (b) that could reasonably be expected to result in a Material Adverse Change;

 

8.12           Lien Priority.   Except as permitted by Agent, any Lien created hereunder or by any other Loan Document shall at any time fail to constitute a valid and perfected Lien on all of the Collateral purported to be secured thereby, subject to no prior or equal Lien;

 

8.13           Change in Control.  A Change in Control shall have occurred;

 

8.14           Withdrawals, Recalls, Adverse Test Results and Other Matters not Involving Nesina. The institution of any proceeding by FDA or similar Governmental Authority to order the withdrawal of any Sale Compound from the market or to enjoin Borrower or any representative of Borrower from manufacturing, marketing, selling or distributing any Sale Compound, which, in each case, could reasonably be expected to result in a Material Adverse Change, (b) the institution of any action or proceeding by any DEA, FDA, or any other Governmental Authority to revoke, suspend, reject, withdraw, limit, or restrict any Required Permit held by Borrower or any representative of Borrower, which, in each case, could reasonably be expected to result in a Material Adverse Change,  (c) the commencement of any enforcement action against Borrower by DEA, FDA, or any other Governmental Authority; (d) the recall of any Sale Compound from the market, the voluntary withdrawal of any Sale Compound from the market, or actions to discontinue the sale of any Sale Compound, which in each case could reasonably be expected to result in a Material Adverse Change, or (e) the occurrence of serious adverse test results related to the safety or efficacy  of a Development Compound resulting in the termination of all clinical studies for such Development Compound which could reasonably be expected to result in a Material Adverse Change; or

 

8.15           Withdrawals and Other Matters Involving Nesina.  (a) The institution of any proceeding by the FDA in the United States or similar Governmental Authority in the European Union to order the withdrawal of any marketing authorization granting the right to sell Nesina in the United States or the European Union or to enjoin Borrower or Takeda (or any of its permitted assignees under the Nesina License Agreement) from manufacturing, marketing, selling or distributing Nesina in the United States or the European Union, which, in each case, could reasonably be expected to result in a Material Adverse Change, (b) the institution of any proceeding by the Japanese Ministry of Health, Labour and Welfare or similar Government Authority to (i) order the withdrawal of the marketing authorization granting the right to sell Nesina in Japan or (ii) indefinitely enjoin Borrower or Takeda (or any of its permitted assignees under the Nesina License Agreement) from, marketing or selling Nesina in Japan, (c) the indefinite voluntary withdrawal of Nesina from the market in (i) the United States or European Union, in each case where such voluntary withdrawal could reasonably be expected to result in a Material Adverse Change, or (ii) Japan, (d)  Nesina, for any reason, indefinitely ceases to be sold or marketed in Japan or Borrower is no longer contractually entitled to royalty payments with respect to Nesina in Japan.

 

  

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9.           RIGHTS AND REMEDIES

 

9.1           Rights and Remedies.

 

(a)           Upon the occurrence and during the continuance of an Event of Default,  Agent may, and at the written direction of the Required Lenders shall,  without notice or demand, do any or all of the following: (i) deliver notice of the Event of Default to Borrower, (ii) by notice to Borrower declare all Obligations immediately due and payable (but if an Event of Default described in Section 8.5 occurs all Obligations shall be immediately due and payable without any action by Agent or the Lenders), or (iii) by notice to Borrower suspend or terminate the obligations, if  any, of the Lenders to advance money or extend credit for Borrower’s benefit under this Agreement or under any other agreement between Borrower and Agent and/or the Lenders (but if an Event of Default described in Section 8.5 occurs all obligations, if any, of the Lenders to  advance money or extend credit for Borrower’s benefit under this Agreement or under any other agreement between Borrower and Agent and/or the Lenders shall be immediately terminated without any action by Agent or the Lenders).

 

(b)                   Without limiting the rights of Agent and Lenders set forth in Section 9.1(a) above, upon the occurrence and during the continuance of an Event of Default Agent shall have the right, at the written direction of the Required Lenders, without notice or demand, to do any or all of the following:

 

(i)         foreclose upon and/or sell or otherwise liquidate, the Collateral;

 

(ii)        apply to the Obligations any (a) balances and deposits of Borrower that Agent or any Lender holds or controls, or (b) any amount held or controlled by Agent or any Lender owing to or for the credit or the account of Borrower; and/or

 

(iii)       commence and prosecute an Insolvency Proceeding or consent to Borrower commencing any Insolvency Proceeding.

 

(c)                       Without limiting the rights of Agent and Lenders set forth in Sections 9.1(a) and (b) above, upon the occurrence and during the continuance of an Event of Default Agent shall have the right, without notice or demand, to do any or all of the following:

 

(i)            settle or adjust disputes and claims directly with Account Debtors for amounts on terms and in any order that Agent considers advisable, notify any Person owing Borrower money of Agent’s security interest in such funds, and verify the amount of such Account;

 

(ii)           make any payments and do any acts it considers necessary or reasonable to protect the Collateral and/or its security interest in the Collateral.  Borrower shall assemble the Collateral if Agent requests and make it available as Agent designates.  Agent may enter premises where the Collateral is located, take and maintain possession of any part of the Collateral, and pay, purchase, contest, or compromise any Lien which appears to be prior or superior to its security interest and pay all expenses incurred. Borrower grants Agent a license to enter and occupy any of its premises, without charge, to exercise any of Agent’s rights or remedies;

 

(iii)          ship, reclaim, recover, store, finish, maintain, repair, prepare for sale, and/or advertise for sale, the Collateral.  Agent is hereby granted a non-exclusive, royalty-free license or other right to use, without charge, Borrower’s labels, patents, copyrights, mask works, rights of use of any name, trade secrets, trade names, trademarks, service marks, and advertising matter, or any similar property as it pertains to the Collateral, in completing production of, advertising for sale, and selling any Collateral and, in connection with Agent’s exercise of its rights under this Section 9.1, Borrower’s rights under all licenses and all franchise agreements inure to Agent for the  benefit of the Lenders;

 

(iv)          place a “hold” on any account maintained with Agent or the Lenders and/or deliver a notice of exclusive control, any entitlement order, or other directions or instructions pursuant to any Control Agreement or similar agreements providing control of any Collateral;

 

(v)          demand and receive possession of Borrower’s Books; and

 

(vi)         subject to clauses 9.1(a) and (b), exercise all rights and remedies available to Agent under the Loan Documents or at law or equity, including all remedies provided under the Code (including disposal of the Collateral pursuant to the terms thereof).

 

  

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Notwithstanding any provision of this Section 9.1 to the contrary, upon the occurrence of any Event of Default, Agent shall have the right to exercise any and all remedies referenced in this Section 9.1 without the written consent of Required Lenders following the occurrence of an Exigent Circumstance.  As used in the immediately preceding sentence, “Exigent Circumstance” means any event or circumstance that, in the reasonable judgment of Agent, imminently threatens the ability of Agent to realize upon all or any material portion of the Collateral, such as, without limitation, fraudulent removal, concealment, or abscondment thereof, destruction or material waste thereof, or failure of Borrower after reasonable demand to maintain or reinstate adequate casualty insurance coverage, or which, in the judgment of Agent, could result in a material diminution in value of the Collateral.

 

9.2           Power of Attorney.  Borrower hereby irrevocably appoints Agent as its lawful attorney-in-fact, exercisable upon the occurrence and during the continuance of an Event of Default, to:  (a) endorse Borrower’s name on any checks or other forms of payment or security; (b) sign Borrower’s name on any invoice or bill of lading for any Account or drafts against Account Debtors; (c) settle and adjust disputes and claims about the Accounts directly with Account Debtors, for amounts and on terms Agent determines reasonable; (d) make, settle, and adjust all claims under Borrower’s insurance policies; (e) pay, contest or settle any Lien, charge, encumbrance, security interest, and adverse claim in or to the Collateral, or any judgment based thereon, or otherwise take any action to terminate or discharge the same; and (f) transfer the Collateral into the name of Agent or a third party as the Code permits.  Borrower hereby appoints Agent as its lawful attorney-in-fact to sign Borrower’s name on any documents necessary to perfect or continue the perfection of Agent’s security interest in the Collateral regardless of whether an Event of Default has occurred until all Obligations have been satisfied in full and Agent and the Lenders are under no further obligation to make Credit Extensions hereunder.  Agent’s foregoing appointment as Borrower’s attorney in fact, and all of Agent’s rights and powers, coupled with an interest, are irrevocable until all Obligations have been fully repaid and performed and Agent’s and the Lenders’ obligation to provide Credit Extensions terminates.

 

9.3           Protective Payments.  If Borrower fails to obtain the insurance called for by Section 6.5 or fails to pay any premium thereon or fails to pay any other amount which Borrower is obligated to pay under this Agreement or any other Loan Document, Agent may obtain such insurance or make such payment, and all amounts so paid by Agent are Lenders’ Expenses and immediately due and payable, bearing interest at the then highest applicable rate, and secured by the Collateral.  Agent will make reasonable efforts to provide Borrower with notice of Agent obtaining such insurance at the time it is obtained or within a reasonable time thereafter.  No such payments by Agent are deemed an agreement to make similar payments in the future or Agent’s waiver of any Event of Default.

 

9.4           Application of Payments and Proceeds.  Notwithstanding anything to the contrary contained in this Agreement, upon the occurrence and during the continuance of an Event of Default, (a) Borrower irrevocably waives the right to direct the application of any and all payments at any time or times thereafter received by Agent from or on behalf of Borrower of all or any part of the Obligations, and, as between Borrower on the one hand and Agent and Lenders on the other, Agent shall have the continuing and exclusive right to apply and to reapply any and all payments received against the Obligations in such manner as Agent may deem advisable notwithstanding any previous application by Agent, and (b) the proceeds of any sale of, or other realization upon all or any part of the Collateral shall be applied: first, to the Lenders Expenses; second, to accrued and unpaid interest on the Obligations (including any interest which, but for the provisions of the United States Bankruptcy Code, would have accrued on such amounts); third, to the principal amount of the Obligations outstanding; and fourth, to any other indebtedness or obligations of Borrower owing to Agent or any Lender under the Loan Documents.  Any balance remaining shall be delivered to Borrower or to whoever may be lawfully entitled to receive such balance or as a court of competent jurisdiction may direct.  In carrying out the foregoing, (x) amounts received shall be applied in the numerical order provided until exhausted prior to the application to the next succeeding category, and (y) each of the Persons entitled to receive a payment in any particular category shall receive an amount equal to its pro rata share of amounts available to be applied pursuant thereto for such category.  Any reference in this Agreement to an allocation between or sharing by the Lenders of any right, interest or obligation “ratably,” “proportionally” or in similar terms shall refer to Pro Rata Share unless expressly provided otherwise.  Agent, or if applicable, each Lender, shall promptly remit to the other Lenders such sums as may be necessary to ensure the ratable repayment of each Lender’s portion of any Term Loan and the ratable distribution of interest, fees and reimbursements paid or made by Borrower.  Notwithstanding the foregoing, a Lender receiving a scheduled payment shall not be responsible for determining whether the other Lenders also received their scheduled payment on such date; provided, however, if it is later determined that a Lender received more than its ratable share of scheduled payments made on any date or dates, then such Lender shall remit to the Agent or other Lenders such sums as may be necessary to ensure the ratable payment of such scheduled payments, as instructed by Agent.  Any payment or distribution of any kind or character, whether in cash, properties or securities, shall be received by a Lender in excess of its ratable share, then the portion of such payment or distribution in excess of such Lender’s ratable share shall be received by such Lender in trust for and shall be promptly paid over to the other Lender for application to the payments of amounts due on the other Lender’s claims.  To the extent any payment for the account of Borrower is required to be returned as a voidable transfer or otherwise, the Lenders shall contribute to one another as is necessary to ensure that such return of payment is on a pro rata basis.  If any Lender shall obtain possession of any Collateral, it shall hold such Collateral for itself and as agent and bailee for the Agent and other Lenders for purposes of perfecting Agent’s security interest therein. Notwithstanding anything to the contrary herein, any warrants issued to the Lenders by Borrower, the stock issuable thereunder, any equity securities purchased by Lenders, any amounts paid thereunder, any dividends, and any other rights in connection therewith shall not be subject to the terms and conditions of this Agreement.  Nothing herein shall affect any Lender’s rights under any such warrants, stock, or other equity securities to administer, manage, transfer, assign, or exercise such warrants, stock, or other equity securities for its own account.

 

  

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9.5           Liability for Collateral.  So long as Agent and the Lenders comply with reasonable banking practices regarding the safekeeping of the Collateral in the possession or under the control of Agent and the Lenders, Agent and the Lenders shall not be liable or responsible for: (a) the safekeeping of the Collateral; (b) any loss or damage to the Collateral; (c) any diminution in the value of the Collateral; or (d) any act or default of any carrier, warehouseman, bailee, or other Person.  Borrower bears all risk of loss, damage or destruction of the Collateral.

 

9.6           No Waiver; Remedies Cumulative.  Agent’s failure, at any time or times, to require strict performance by Borrower of any provision of this Agreement or any other Loan Document shall not waive, affect, or diminish any right of Agent thereafter to demand strict performance and compliance herewith or therewith.  No waiver hereunder shall be effective unless signed by Agent and then is only effective for the specific instance and purpose for which it is given.  Agent’s rights and remedies under this Agreement and the other Loan Documents are cumulative.  Agent has all rights and remedies provided under the Code, by Law, or in equity.  Agent’s exercise of one right or remedy is not an election, and Agent’s waiver of any Event of Default is not a continuing waiver.  Agent’s delay in exercising any remedy is not a waiver, election, or acquiescence.

 

9.7           Demand Waiver.  Borrower waives demand, notice of default or dishonor, notice of payment and nonpayment, notice of any default, nonpayment at maturity, release, compromise, settlement, extension, or renewal of accounts, documents, instruments, chattel paper, and guarantees held by Agent on which Borrower is liable.

 

9.8           Borrower Liability.  Each Borrower hereby appoints the others as agent for the others for all purposes hereunder, including with respect to requesting the Term Loan hereunder.  Each Borrower hereunder shall be jointly and severally obligated to repay the Term Loan made hereunder and all other Obligations, regardless of which Borrower actually receives said Term Loan, as if each Borrower hereunder directly received the Term Loan.  Each Borrower waives (a) any suretyship defenses available to it under the Code or any other applicable law, and (b) any right to require the Lenders or Agent to: (i) proceed against any Borrower or any other person; (ii) proceed against or exhaust any security; or (iii) pursue any other remedy.  The Lenders or Agent may exercise or not exercise any right or remedy they have against any Borrower or any security (including the right to foreclose by judicial or non-judicial sale) without affecting any Borrower’s liability.  Notwithstanding any other provision of this Agreement or other related document, each Borrower irrevocably waives all rights that it may have at law or in equity (including, without limitation, any law subrogating Borrower to the rights of the Lenders and Agent under this Agreement) to seek contribution, indemnification or any other form of reimbursement from any other Borrower, or any other Person now or hereafter primarily or secondarily liable for any of the Obligations, for any payment made by Borrower with respect to the Obligations in connection with this Agreement or otherwise and all rights that it might have to benefit from, or to participate in, any security for the Obligations as a result of any payment made by Borrower with respect to the Obligations in connection with this Agreement or otherwise.  Any agreement providing for indemnification, reimbursement or any other arrangement prohibited under this Section shall be null and void.  If any payment is made to a Borrower in contravention of this Section, such Borrower shall hold such payment in trust for the Lenders and Agent and such payment shall be promptly delivered to Agent for application to the Obligations, whether matured or unmatured.

 

  

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10.           NOTICES

 

All notices, consents, requests, approvals, demands, or other communication (collectively, “Communication”) by any party to this Agreement or any other Loan Document must be in writing and shall be deemed to have been validly served, given, or delivered: (a) upon the earlier of actual receipt and three (3) Business Days after deposit in the U.S. mail, first class, registered or certified mail return receipt requested, with proper postage prepaid; (b) upon transmission, when sent by electronic mail (if an email address is specified herein) or facsimile transmission; (c) one (1) Business Day after deposit with a reputable overnight courier with all charges prepaid; or (d) when delivered, if hand-delivered by messenger, all of which shall be addressed to the party to be notified and sent to the address, facsimile number, or email address indicated below.  Any of Agent, Lender or Borrower may change its mailing or electronic mail address or facsimile number by giving the other party written notice thereof in accordance with the terms of this Section 10.

 

If to any Borrower:

Furiex Pharmaceuticals, Inc.

3900 Paramount Parkway, Suite 150

Morrisville, North Carolina 27560

Attention:  President and Chief Financial Officer

Fax:  (919) 456-7850

E-Mail: June.Almenoff@furiex.com

              Marshall.Woodworth@furiex.com

If to Agent :

MidCap Funding III, LLC

7255 Woodmont Avenue, Suite 200

Bethesda, Maryland 20814

Attention: Portfolio Management- Life Sciences

Fax:  (301) 941-1450

E-Mail: Lviera@midcapfinancial.com

with a copy to:

Midcap Financial, LLC

7255 Woodmont Avenue, Suite 200

Bethesda, Maryland 20814

Attention:  General Counsel

Fax:  (301) 941-1450

E-Mail: Rgoodridge@midcapfinancial.com

If to Lenders:  To the address specified on the signature page of such Lender attached hereto or on any Assignment Agreement to which such Lender has become a party to this Agreement in accordance with Section 12.1.

 

  

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11.           CHOICE OF LAW, VENUE AND JURY TRIAL WAIVER

 

THIS AGREEMENT, EACH SECURED PROMISSORY NOTE AND EACH OTHER LOAN DOCUMENT, AND ALL MATTERS RELATING HERETO OR THERETO OR ARISING THEREFROM (WHETHER SOUNDING IN CONTRACT LAW, TORT LAW OR OTHERWISE), SHALL BE GOVERNED BY, AND SHALL BE CONSTRUED AND ENFORCED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF MARYLAND, WITHOUT REGARD TO CONFLICTS OF LAWS PRINCIPLES.  NOTWITHSTANDING THE FOREGOING, AGENT AND LENDERS SHALL HAVE THE RIGHT TO BRING ANY ACTION OR PROCEEDING AGAINST BORROWER OR ITS PROPERTY IN THE COURTS OF ANY OTHER JURISDICTION WHICH AGENT AND LENDERS (IN ACCORDANCE WITH THE PROVISIONS OF SECTION 9.1) DEEM NECESSARY OR APPROPRIATE TO REALIZE ON THE COLLATERAL OR TO OTHERWISE ENFORCE AGENT’S AND LENDERS’ RIGHTS AGAINST BORROWER OR ITS PROPERTY. BORROWER EXPRESSLY SUBMITS AND CONSENTS IN ADVANCE TO SUCH JURISDICTION IN ANY ACTION OR SUIT COMMENCED IN ANY SUCH COURT, AND BORROWER HEREBY WAIVES ANY OBJECTION THAT IT MAY HAVE BASED UPON LACK OF PERSONAL JURISDICTION, IMPROPER VENUE, OR FORUM NON CONVENIENS AND HEREBY CONSENTS TO THE GRANTING OF SUCH LEGAL OR EQUITABLE RELIEF AS IS DEEMED APPROPRIATE BY SUCH COURT.  BORROWER HEREBY WAIVES PERSONAL SERVICE OF THE SUMMONS, COMPLAINTS, AND OTHER PROCESS ISSUED IN SUCH ACTION OR SUIT AND AGREES THAT SERVICE OF SUCH SUMMONS, COMPLAINTS, AND OTHER PROCESS MAY BE MADE BY REGISTERED OR CERTIFIED MAIL ADDRESSED TO BORROWER AT THE ADDRESS SET FORTH IN SECTION 10 OF THIS AGREEMENT AND THAT SERVICE SO MADE SHALL BE DEEMED COMPLETED UPON THE EARLIER TO OCCUR OF BORROWER’S ACTUAL RECEIPT THEREOF OR THREE (3) DAYS AFTER DEPOSIT IN THE U.S. MAILS, PROPER POSTAGE PREPAID.

TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, BORROWER, AGENT AND LENDERS EACH WAIVE THEIR RIGHT TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION ARISING OUT OF OR BASED UPON THIS AGREEMENT, THE LOAN DOCUMENTS OR ANY CONTEMPLATED TRANSACTION, INCLUDING CONTRACT, TORT, BREACH OF DUTY AND ALL OTHER CLAIMS. THIS WAIVER IS A MATERIAL INDUCEMENT FOR BOTH PARTIES TO ENTER INTO THIS AGREEMENT.  EACH PARTY HAS REVIEWED THIS WAIVER WITH ITS COUNSEL.

 

Borrower, Agent and each Lender agree that the Term Loan (including the Initial Funding and the Subsequent Funding), as well as the Existing Term Loan, shall be deemed to be made in, and the transactions contemplated hereunder and in any other Loan Document shall be deemed to have been performed in, the State of Maryland.

 

12.           GENERAL PROVISIONS

 

12.1           Successors and Assigns. This Agreement binds and is for the benefit of the successors and permitted assigns of each party.  Borrower may not assign this Agreement or any rights or obligations under it without Agent’s prior written consent (which may be granted or withheld in Agent’s discretion).   Any Lender may at any time assign to one or more Eligible Assignees all or any portion of such Lender’s Loan, together with all related obligations of such Lender hereunder.  Borrower and Agent shall be entitled to continue to deal solely and directly with such Lender in connection with the interests so assigned until Agent shall have received and accepted an effective assignment agreement in form and substance acceptable to Agent, executed, delivered and fully completed by the applicable parties thereto (each, an “Assignment Agreement”), and shall have received such other information regarding such Eligible Assignee as Agent reasonably shall require.  Notwithstanding anything set forth in this Agreement to the contrary, any Lender may at any time pledge or assign a security interest in all or any portion of its rights under this Agreement to secure obligations of such Lender, including any pledge or assignment to secure obligations to a Federal Reserve Bank; provided, however, that no such pledge or assignment shall release such Lender from any of its obligations hereunder or substitute any such pledgee or assignee for such Lender as a party hereto.

 

12.2           Indemnification.

 

(a)           Borrower agrees to indemnify, defend and hold Agent and the Lenders and their respective directors, officers, employees, agents, attorneys, or any other Person affiliated with or representing Agent or the Lenders  (each, an “Indemnified Person”) harmless against: (i) all obligations, demands, claims, and liabilities (collectively, “Claims”) asserted by any other party in connection with the transactions contemplated by the Loan Documents; and (ii) all losses or Lenders’ Expenses incurred, or paid by Indemnified Person from, following, or arising from transactions between Agent, and/or the Lenders and Borrower (including reasonable attorneys’ fees and expenses) pursuant to or in connection with the Loan Documents, except for Claims and/or losses directly caused by such Indemnified Person’s  gross negligence or willful misconduct (collectively, the “Indemnified Liabilities”).

 

  

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(b)           Borrower hereby further indemnifies, defends and holds each Indemnified Person harmless from and against any and all liabilities, obligations, losses, damages, penalties, actions, judgments, suits, claims, costs, expenses and disbursements of any kind or nature whatsoever (including the fees and disbursements of counsel for such Indemnitee) in connection with any investigative, response, remedial, administrative or judicial matter or proceeding, whether or not such Indemnified Person shall be designated a party thereto and including any such proceeding initiated by or on behalf of Borrower, and the reasonable expenses of investigation by engineers, environmental consultants and similar technical personnel and any commission, fee or compensation claimed by any broker (other than any broker retained by Agent or Lenders) asserting any right to payment for the transactions contemplated hereby which may be imposed on, incurred by or asserted against such Indemnified Person as a result of or in connection with the transactions contemplated hereby and the use or intended use of the proceeds of the loan proceeds.

 

(c)           To the extent that the undertaking set forth in this Section 12.2 may be unenforceable, Borrower shall contribute the maximum portion which it is permitted to pay and satisfy under applicable law to the payment and satisfaction of all such indemnified liabilities incurred by the Indemnitees or any of them.

 

12.3          Time of Essence.  Time is of the essence for the performance of all Obligations in this Agreement.

 

12.4          Severability of Provisions.  Each provision of this Agreement is severable from every other provision in determining the enforceability of any provision.

 

12.5          Correction of Loan Documents.  Agent and the Lenders may correct patent errors and fill in any blanks in this Agreement and the other Loan Documents consistent with the agreement of the parties.

 

12.6          Integration.  This Agreement and the Loan Documents represent the entire agreement about this subject matter and supersede prior negotiations or agreements.  All prior agreements, understandings, representations, warranties, and negotiations between the parties about the subject matter of this Agreement and the Loan Documents merge into this Agreement and the Loan Documents.

 

12.7          Counterparts.  This Agreement may be executed in any number of counterparts and by different parties on separate counterparts, each of which, when executed and delivered, is an original, and all taken together, constitute one Agreement.

 

12.8          Survival.  All covenants, representations and warranties made in this Agreement continue in full force until this Agreement has terminated pursuant to its terms and all Obligations (other than inchoate indemnity obligations and any other obligations which, by their terms, are to survive the termination of this Agreement) have been satisfied.  The obligation of Borrower in Section 12.2 to indemnify each Lender and Agent shall survive until the statute of limitations with respect to such claim or cause of action shall have run.

 

12.9          Confidentiality.  In handling any confidential information of Borrower, the Lenders and Agent shall exercise the same degree of care that it exercises for its own proprietary information, but disclosure of information may be made: (a) to the Lenders’ and Agent’s Subsidiaries or Affiliates; (b) to prospective transferees or purchasers of any interest in the Credit Extensions (provided, however, the Lenders and Agent shall use commercially reasonable efforts to obtain such prospective transferee’s or purchaser’s agreement to the terms of this provision); (c) as required by Law, regulation, subpoena, or other order; (d) to regulators or as otherwise required in connection with an examination or audit; (e) as Agent considers appropriate in exercising remedies under the Loan Documents; and (f) to third party service providers of the Lenders and/or Agent so long as such service providers have executed a confidentiality agreement with the Lenders and Agent with terms no less restrictive than those contained herein. Confidential information does not include information that either: (i) is in the public domain or in the Lenders’ and/or Agent’s possession when disclosed to the Lenders and/or Agent, or becomes part of the public domain after disclosure to the Lenders and/or Agent; or (ii) is disclosed to the Lenders and/or Agent by a third party, if the Lenders and/or Agent does not know that the third party is prohibited from disclosing the information.  Agent and/or Lenders may use confidential information for any purpose, including, without limitation, for the development of client databases, reporting purposes, and market analysis, so long as Agent and/or Lenders, as applicable, do not disclose Borrower’s identity or the identity of any Person associated with Borrower unless otherwise expressly permitted by this Agreement.  The provisions of the immediately preceding sentence shall survive the termination of this Agreement. The agreements provided under this Section 12.9 supersede all prior agreements, understanding, representations, warranties, and negotiations between the parties about the subject matter of this Section 12.9.

 

  

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12.10          Right of Set Off.   Borrower hereby grants to Agent and to each Lender, a lien, security interest and right of set off as security for all Obligations to Agent and each Lender hereunder, whether now existing or hereafter arising upon and against all deposits, credits, collateral and property, now or hereafter in the possession, custody, safekeeping or control of Agent or the Lenders or any entity under the control of Agent or the Lenders (including a Agent affiliate) or in transit to any of them.  At any time after the occurrence and during the continuance of an Event of Default, without demand or notice, Agent or the Lenders may set off the same or any part thereof and apply the same to any liability or obligation of Borrower even though unmatured and regardless of the adequacy of any other collateral securing the Obligations.  ANY AND ALL RIGHTS TO REQUIRE AGENT TO EXERCISE ITS RIGHTS OR REMEDIES WITH RESPECT TO ANY OTHER COLLATERAL WHICH SECURES THE OBLIGATIONS, PRIOR TO EXERCISING ITS RIGHT OF SETOFF WITH RESPECT TO SUCH DEPOSITS, CREDITS OR OTHER PROPERTY OF BORROWER ARE HEREBY KNOWINGLY, VOLUNTARILY AND IRREVOCABLY WAIVED.

 

12.11          [Reserved.]

 

12.12          Amendments.

 

 (a)            No amendment, modification, termination or waiver of any provision of this Agreement or any other Loan Document, nor approval or consent thereunder, or any consent to any departure by Borrower therefrom, shall in any event be effective unless the same shall be in writing and signed by Borrower, Agent and the Required Lenders, provided, however, that

 

 (i)             no such amendment, waiver or other modification that would have the effect of increasing or reducing a Lender’s Term Loan Commitment or Commitment Percentage shall be effective as to such Lender without such Lender’s written consent;

 

 (ii)            no such amendment, waiver or modification that would affect the rights and duties of Agent shall be effective without Agent’s written consent or signature;

 

 (iii)           no such amendment, waiver or other modification shall, unless signed by all the Lenders directly affected thereby, (A) reduce the principal of, rate of interest on or any fees with respect to the Term Loan or forgive any principal, interest (other than default interest) or fees (other than late charges) with respect to the Term Loan (B) postpone the date fixed for, or waive, any payment of principal of the Term Loan or of interest on the Term Loan (other than default interest) or any fees provided for hereunder (other than late charges or for any termination of any commitment); (C) change the definition of the term “Required Lenders” or the percentage of Lenders which shall be required for Lenders to take any action hereunder; (D) release all or substantially all or any material portion of the Collateral, authorize Borrower to sell or otherwise dispose of all or substantially all or any material portion of the Collateral or release any Guarantor of all or any portion of the Obligations or its guaranty obligations with respect thereto, except, in each case with respect to this clause (D), as otherwise may be expressly permitted under this Agreement or the other Loan Documents (including in connection with any disposition permitted hereunder); (E) amend, waive or otherwise modify this Section 12.12 or the definitions of the terms used in this Section 12.12 insofar as the definitions affect the substance of this Section 12.12; (F) consent to the assignment, delegation or other transfer by any Borrower or any Guarantor of any of its rights and obligations under any Loan Document or release Borrower or any Guarantor of its payment obligations under any Loan  Document, except, in each case with respect to this clause (F), pursuant to a merger or consolidation permitted pursuant to this Agreement; (G) amend any of the provisions of Section 9.4 or amend any of the definitions Pro Rata Share, Term Loan Commitment, Commitment Percentage or that provide for the Lenders to receive their Pro Rata Shares of any fees, payments, setoffs or proceeds of Collateral hereunder; (H) subordinate the Liens granted in favor of Agent securing the Obligations; or (I) amend any of the provisions of Section 12.10.  It is hereby understood and agreed that all Lenders shall be deemed directly affected by an amendment, waiver or other modification of the type described in the preceding clauses (C), (D), (E), (F), (G) and (H) of the preceding sentence;

 

  

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(iv)           the provisions of the foregoing clauses (i), (ii) and (iii) are subject to the provisions of any interlender or agency agreement among the Agent and Lenders pursuant to which any Lender may agree to give its consent in connection with any amendment, waiver or modification of the Loan Documents only in the event of the unanimous agreement of all Lenders.

 

(b)           Other than as expressly provided for in Section 12.12(a)(i) through (iii) above, Agent may, if requested by the Required Lenders, from time to time designate covenants in this Agreement less restrictive by notification to a representative of the Borrower.

 

12.13          Publicity.  Borrower will not directly or indirectly publish, disclose or otherwise use in any public disclosure, advertising material, promotional material, press release or interview, any reference to the name, logo or any trademark of Agent or any Lender or any of their Affiliates or any reference to this Agreement or the financing evidenced hereby, in any case except as required by applicable Law, subpoena or judicial or similar order, in which case Borrower shall endeavor to give Agent prior written notice of such publication or other disclosure; provided, however, that for the avoidance of doubt, Borrower may publish the name of Lenders and Agent, the existence of the financing arrangements referenced under this Agreement, the primary purpose and/or structure of those arrangements, the amount of credit extended under each facility, the title and role of each party to this Agreement, and the total amount of financing evidenced hereby and such other information (including copies of the Loan Documents) necessary to satisfy the reporting requirements under the Securities Exchange Act of 1934, as amended.  Each Lender and Borrower hereby authorizes each Lender to publish the name of such Lender and Borrower, the existence of the financing arrangements referenced under this Agreement, the primary purpose and/or structure of those arrangements, the amount of credit extended under each facility, the title and role of each party to this Agreement, and the total amount of the financing evidenced hereby in any “tombstone”, comparable advertisement or press release which such Lender elects to submit for publication.  In addition, each Lender and Borrower agrees that each Lender may provide lending industry trade organizations with information necessary and customary for inclusion in league table measurements after the Restatement Date.  With respect to any of the foregoing authorizations granted to Lenders, such authorization shall be subject to such Lender providing Borrower and the other Lenders with an opportunity to review and confer with such Lender regarding, and approve, the contents of any such tombstone, advertisement or information, as applicable, prior to its initial submission for publication, but subsequent publications of the same tombstone, advertisement or information shall not require Borrower’s approval.

 

12.14          No Strict Construction. The parties hereto have participated jointly in the negotiation and drafting of this Agreement.  In the event an ambiguity or question of intent or interpretation arises, this Agreement shall be construed as if drafted jointly by the parties hereto and no presumption or burden of proof shall arise favoring or disfavoring any party by virtue of the authorship of any provisions of this Agreement.

 

12.15          Amendment and Restatement; No Novation.

 

(a)           On the Restatement Date upon the satisfaction of the conditions precedent in Section 3.1, the Existing Loan Agreement shall be amended and restated in its entirety.  The Existing Term Loan outstanding on the Restatement Date shall be reallocated in accordance with the terms set forth in Section 2.1.

 

  

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(b)           The parties hereto acknowledge and agree that (i) this Agreement and the other Loan Documents, whether executed and delivered in connection herewith or otherwise, do not constitute a novation or termination of the Existing Obligations under the Existing Loan Agreement as in effect prior to the Restatement Date and which remain outstanding and are in all respects continuing (as amended and restated hereby), (ii) the Liens and security interests as granted under the Existing Loan Agreement and other Existing Loan Documents securing payment of such Existing Obligations are in all respects continuing and in full force and effect after giving effect to this Agreement and the transactions contemplated hereby and all such Liens granted to the Existing Agent shall be deemed to constitute Liens granted to the Agent on behalf of the Lenders under this Agreement, (iii) references in the Existing Loan Documents or the Loan Documents to the “Loan Agreement” shall be deemed to be references to this Agreement (as the same may be amended, restated, supplemented or otherwise modified from time to time), and to the extent necessary to effect the foregoing, each such Loan Document is hereby deemed amended accordingly, (iv) all of the terms and provisions of the Existing Loan Agreement shall continue to apply for the period prior to the Restatement Date, including any determinations of payment dates, interest rates, Events of Default or any amount that may be payable to the Agent or the Lenders (or their assignees or replacements hereunder), (v) the Existing Obligations under the Existing Loan Agreement shall continue to be paid or prepaid on or prior to the Restatement Date, and shall from and after the Restatement Date continue to be owing and be subject to the terms of this Agreement, (vi) all references in the Loan Documents to the “Lenders” or a “Lender” shall be deemed to refer to such terms as defined in this Agreement, and to the extent necessary to effect the foregoing, each such Loan Document is hereby deemed amended accordingly and (vii) any Defaults or Events of Default that are continuing under the Existing Loan Agreement shall constitute Defaults or Events of Default under this Agreement unless the same shall have been specifically waived in writing in accordance with this Agreement, and to the extent necessary to effect the foregoing, each such Loan Document is hereby deemed amended accordingly.

 

(c)           The Borrower, Loan Parties, Agent and Lenders acknowledge and agree that all principal, interest, fees, costs, reimbursable expenses and indemnification obligations accruing or arising under or in connection with the Existing Loan Agreement which remain unpaid and outstanding as of the Restatement Date shall be and remain outstanding and payable as an obligation under this Agreement and the other Loan Documents.

 

(d)           The parties hereto agree that as of the Restatement Date, (i) the Lenders signatory hereto shall become “Lenders” under this Agreement and the other Loan Documents and (ii) each Lender shall have the Term Loan Commitment set forth on Schedule 1 hereto.  Borrower hereby directs Agent to apply the proceeds of the Term Loan made on the Restatement Date to the repayment on the Restatement Date of certain outstanding loans and obligations of the Borrower owing to the Existing Lenders and to the payment of certain fees and expenses relating thereto.  The parties hereto have participated jointly in the negotiation and drafting of this Agreement.  In the event an ambiguity or question of intent or interpretation arises, this Agreement shall be construed as if drafted jointly by the parties hereto and no presumption or burden of proof shall arise favoring or disfavoring any party by virtue of the authorship of any provisions of this Agreement.

 

13.           AGENT

 

13.1          Appointment and Authorization of Agent. Each Lender hereby irrevocably appoints, designates and authorizes Agent to take such action on its behalf under the provisions of this Agreement and each other Loan Document and to exercise such powers and perform such duties as are expressly delegated to it by the terms of this Agreement or any other Loan Document, together with such powers as are reasonably incidental thereto. Notwithstanding any provision to the contrary contained elsewhere herein or in any other Loan Document, Agent shall not have any duties or responsibilities, except those expressly set forth herein, nor shall Agent have or be deemed to have any fiduciary relationship with any Lender or participant, and no implied covenants, functions, responsibilities, duties, obligations or liabilities shall be read into this Agreement or any other Loan Document or otherwise exist against Agent. Without limiting the generality of the foregoing sentence, the use of the term “agent” herein and in the other Loan Documents with reference to Agent is not intended to connote any fiduciary or other implied (or express) obligations arising under agency doctrine of any applicable Law. Instead, such term is used merely as a matter of market custom, and is intended to create or reflect only an administrative relationship between independent contracting parties.

 

13.2          Delegation of Duties. Agent may execute any of its duties under this Agreement or any other Loan Document by or through its, or its Affiliates’, agents, employees or attorneys-in-fact and shall be entitled to obtain and rely upon the advice of counsel and other consultants or experts concerning all matters pertaining to such duties. Agent shall not be responsible for the negligence or misconduct of any agent or attorney-in-fact that it selects in the absence of gross negligence or willful misconduct.

 

13.3          Liability of Agent. Except as otherwise provided herein, no Agent-Related Person shall (a) be liable for any action taken or omitted to be taken by any of them under or in connection with this Agreement or any other Loan Document or the transactions contemplated hereby (except for its own gross negligence or willful misconduct in connection with its duties expressly set forth herein), or (b) be responsible in any manner to any Lender or participant for any recital, statement, representation or warranty made by Borrower or any officer thereof, contained herein or in any other Loan Document, or in any certificate, report, statement or other document referred to or provided for in, or received by Agent under or in connection with, this Agreement or any other Loan Document, or the validity, effectiveness, genuineness, enforceability or sufficiency of this Agreement or any other Loan Document, or for any failure of Borrower or any other party to any Loan Document to perform its obligations hereunder or thereunder. No Agent-Related Person shall be under any obligation to any Lender or participant to ascertain or to inquire as to the observance or performance of any of the agreements contained in, or conditions of, this Agreement or any other Loan Document, or to inspect the properties, books or records of Borrower or any Affiliate thereof.

 

  

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13.4          Reliance by Agent. Agent shall be entitled to rely, and shall be fully protected in relying, upon any writing, communication, signature, resolution, representation, notice, consent, certificate, affidavit, letter, telegram, facsimile, telex or telephone message, electronic mail message, statement or other document or conversation believed by it to be genuine and correct and to have been signed, sent or made by the proper Person or Persons, and upon advice and statements of legal counsel (including counsel to Borrower), independent accountants and other experts selected by Agent. Agent shall be fully justified in failing or refusing to take any action under any Loan Document unless it shall first receive such advice or concurrence of all Lenders as it deems appropriate and, if it so requests, it shall first be indemnified to its satisfaction by the Lenders against any and all liability and expense which may be incurred by it by reason of taking or continuing to take any such action. Agent shall in all cases be fully protected in acting, or in refraining from acting, under this Agreement or any other Loan Document in accordance with a request or consent of all Lenders and such request and any action taken or failure to act pursuant thereto shall be binding upon all the Lenders.

 

13.5          Notice of Default. Agent shall not be deemed to have knowledge or notice of the occurrence of any Default and/or Event of Default, unless Agent shall have received written notice from a Lender or Borrower, describing such default or Event of Default. Agent will notify the Lenders of its receipt of any such notice. Agent shall take such action with respect to an Event of Default as may be directed in writing by the Required Lenders in accordance with Section 9(a); provided, however, that while an Event of Default has occurred and is continuing, Agent may (but shall not be obligated to) take such action, or refrain from taking such action, with respect to such Event of Default as Agent shall deem advisable or in the best interest of the Lenders, including without limitation,  satisfaction of other security interests, liens or encumbrances on the Collateral not permitted under the Loan Documents, payment of taxes on behalf of Borrower, payments to landlords, warehouseman, bailees and other Persons in possession of the Collateral and other actions to protect and safeguard the Collateral, and actions with respect to insurance claims for casualty events affecting Borrower and/or the Collateral.

 

13.6          Credit Decision; Disclosure of Information by Agent. Each Lender acknowledges that no Agent-Related Person has made any representation or warranty to it, and that no act by Agent hereafter taken, including any consent to and acceptance of any assignment or review of the affairs of Borrower or any Affiliate thereof, shall be deemed to constitute any representation or warranty by any Agent-Related Person to any Lender as to any matter, including whether Agent-Related Persons have disclosed material information in their possession. Each Lender represents to Agent that it has, independently and without reliance upon any Agent-Related Person and based on such documents and information as it has deemed appropriate, made its own appraisal of, and investigation into, the business, prospects, operations, property, financial and other condition and creditworthiness of Borrower and its respective Subsidiaries, and all applicable bank or other regulatory Laws relating to the transactions contemplated hereby, and made its own decision to enter into this Agreement and to extend credit to Borrower hereunder. Each Lender also represents that it will, independently and without reliance upon any Agent-Related Person and based on such documents and information as it shall deem appropriate at the time, continue to make its own credit analysis, appraisals and decisions in taking or not taking action under this Agreement and the other Loan Documents, and to make such investigations as it deems necessary to inform itself as to the business, prospects, operations, property, financial and other condition and creditworthiness of Borrower. Except for notices, reports and other documents expressly required to be furnished to the Lenders by Agent herein, Agent shall not have any duty or responsibility to provide any Lender with any credit or other information concerning the business, prospects, operations, property, financial and other condition or creditworthiness of Borrower or any of its Affiliates which may come into the possession of any Agent-Related Person.

 

  

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13.7          Indemnification of Agent. Whether or not the transactions contemplated hereby are consummated, each  Lender shall, severally and pro rata based on its respective Pro Rata Share, indemnify upon demand each Agent-Related Person (to the extent not reimbursed by or on behalf of Borrower and without limiting the obligation of Borrower to do so), and hold harmless each Agent-Related Person from and against any and all Indemnified Liabilities (which shall not include legal expenses of Agent incurred in connection with the closing of the transactions contemplated by this Agreement) incurred by it; provided, however, that no Lender shall be liable for the payment to any Agent-Related Person of any portion of such Indemnified Liabilities to the extent determined in a judgment by a court of competent jurisdiction to have resulted from such Agent-Related Person’s own gross negligence or willful misconduct; provided, however, that no action taken in accordance with the directions of the Required Lenders shall be deemed to constitute gross negligence or willful misconduct for purposes of this Section 13.7. Without limitation of the foregoing, each Lender shall, severally and pro rata based on its respective Pro Rata Share, reimburse Agent upon demand for its ratable share of any costs or out-of-pocket expenses (including Lenders’ Expenses incurred after the closing of the transactions contemplated by this Agreement) incurred by Agent (in its capacity as Agent, and not as a Lender) in connection with the preparation, execution, delivery, administration, modification, amendment or enforcement (whether through negotiations, legal proceedings or otherwise) of, or legal advice in respect of rights or responsibilities under, this Agreement, any other Loan Document, or any document contemplated by or referred to herein, to the extent that Agent is not reimbursed for such expenses by or on behalf of Borrower. The undertaking in this Section 13.7 shall survive the payment in full of the Obligations, the termination of this Agreement and the resignation of Agent.

 

13.8          Agent in its Individual Capacity.  With respect to its Credit Extensions, MidCap shall have the same rights and powers under this Agreement as any other Lender and may exercise such rights and powers as though it were not Agent, and the terms “Lender” and “Lenders” include MidCap in its individual capacity.

 

13.9          Successor Agent.

 

(a)                       Agent may at any time assign its rights, powers, privileges and duties hereunder to (i) another Lender, or (ii) any Person to whom Agent, in its capacity as a Lender, has assigned (or will assign, in conjunction with such assignment of agency rights hereunder) 50% or more of its Loan, in each case without the consent of the Lenders or Borrowers.  Following any such assignment, Agent shall give notice to the Lenders and Borrowers.  An assignment by Agent pursuant to this subsection (a) shall not be deemed a resignation by Agent for purposes of subsection (b) below.

 

(b)                       Without limiting the rights of Agent to designate an assignee pursuant to subsection (a) above, Agent may at any time give notice of its resignation to the Lenders and Borrowers.  Upon receipt of any such notice of resignation, Required Lenders shall have the right to appoint a successor Agent.  If no such successor shall have been so appointed by Required Lenders and shall have accepted such appointment within ten (10) Business Days after the retiring Agent gives notice of its resignation, then the retiring Agent may, on behalf of the Lenders, appoint a successor Agent; provided, however, that if Agent shall notify Borrowers and the Lenders that no Person has accepted such appointment, then such resignation shall nonetheless become effective in accordance with such notice from Agent that no Person has accepted such appointment and, from and following delivery of such notice, (i) the retiring Agent shall be discharged from its duties and obligations hereunder and under the other Loan Documents, and (ii) all payments, communications and determinations provided to be made by, to or through Agent shall instead be made by or to each Lender directly, until such time as Required Lenders appoint a successor Agent as provided for above in this subsection (b).

 

(c)                       Upon (i) an assignment permitted by subsection (a) above, or (ii) the acceptance of a successor’s appointment as Agent pursuant to subsection (b) above, such successor shall succeed to and become vested with all of the rights, powers, privileges and duties of the retiring (or retired) Agent, and the retiring Agent shall be discharged from all of its duties and obligations hereunder and under the other Loan Documents (if not already discharged therefrom as provided above in this subsection (c)).  The fees payable by Borrowers to a successor Agent shall be the same as those payable to its predecessor unless otherwise agreed between Borrower and such successor.  After the retiring Agent’s resignation hereunder and under the other Loan Documents, the provisions of this Section 13 shall continue in effect for the benefit of such retiring Agent and its sub-agents in respect of any actions taken or omitted to be taken by any of them while the retiring Agent was acting or was continuing to act as Agent.

 

  

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13.10          Agent May File Proofs of Claim. In case of the pendency of any receivership, insolvency, liquidation, bankruptcy, reorganization, arrangement, adjustment, composition or other judicial proceeding relative to Borrower, Agent (irrespective of whether the principal of any Loan, shall then be due and payable as herein expressed or by declaration or otherwise and irrespective of whether Agent shall have made any demand on Borrower) shall be entitled and empowered, by intervention in such proceeding or otherwise:

 

(a)                to file and prove a claim for the whole amount of the principal and interest owing and unpaid in respect of the Credit Extensions and all other Obligations that are owing and unpaid and to file such other documents as may be necessary or advisable in order to have the claims of the Lenders and Agent (including any claim for the reasonable compensation, expenses, disbursements and advances of the Lenders and Agent and their respective agents and counsel and all other amounts due the Lenders and Agent allowed in such judicial proceeding); and

 

(b)               to collect and receive any monies or other property payable or deliverable on any such claims and to distribute the same;

 

 

and any custodian, receiver, assignee, trustee, liquidator, sequestrator or other similar official in any such judicial proceeding is hereby authorized by each Lender to make such payments to Agent and, in the event that Agent shall consent to the making of such payments directly to the Lenders, to pay to Agent any amount due for the reasonable compensation, expenses, disbursements and advances of Agent and its agents and counsel, and any other amounts due Agent under Section 2.4(d).  To the extent that Agent fails timely to do so, each Lender may file a claim relating to such Lender’s claim.

13.11        Collateral and Guaranty Matters. The Lenders irrevocably authorize Agent, at its option and in its discretion, to release any Guarantor and any Lien on any Collateral granted to or held by Agent under any Loan Document (a) upon the date that all Obligations due hereunder have been fully and indefeasibly paid in full and no Term Loan Commitments or other obligations of any Lender to provide funds to Borrower under this Agreement remain outstanding, (b) that is transferred or to be transferred as part of or in connection with any Transfer permitted hereunder or under any other Loan Document, or (c) as approved in accordance with Section 12.12. Upon request by Agent at any time, all Lenders will confirm in writing Agent’s authority to release its interest in particular types or items of Property, pursuant to this Section 13.11.

 

13.12        Cooperation of Borrower. If necessary, Borrower agrees to (a) execute any documents (including new Secured Promissory Notes) reasonably required to effectuate and acknowledge each assignment of a Term Loan Commitment or Loan to an assignee in accordance with Section 12.1, (b) make Borrower’s management available to meet with Agent and prospective participants and assignees of Term Loan Commitments or Credit Extensions and (c) assist Agent or the Lenders in the preparation of information relating to the financial affairs of Borrower as any prospective participant or assignee of a Term Loan Commitment or Term Loan reasonably may request. Subject to the provisions of Section 12.9 Borrower authorizes each Lender to disclose to any prospective participant or assignee of a Term Loan Commitment, any and all information in such Lender’s possession concerning Borrower and its financial affairs which has been delivered to such Lender by or on behalf of Borrower pursuant to this Agreement, or which has been delivered to such Lender by or on behalf of Borrower in connection with such Lender’s credit evaluation of Borrower prior to entering into this Agreement.

 

14.           DEFINITIONS

 

As used in this Agreement, the following terms have the following meanings:

 

“Access Agreement” means a landlord consent, bailee letter or warehouseman’s letter, in form and substance reasonably satisfaction to Agent, in favor of Agent executed by such landlord, bailee or warehouseman, as applicable, for any third party location.

 

“Account” means any “account”, as defined in the Code, with such additions to such term as may hereafter be made, and includes, without limitation, all accounts receivable and other sums owing to Borrower.

 

  

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“Account Debtor” means any “account debtor”, as defined in the Code, with such additions to such term as may hereafter be made.

 

“Affiliate” means, with respect to any Person, a Person that owns or controls directly or indirectly the Person, any Person that controls or is controlled by or is under common control with the Person, and each of that Person’s senior executive officers, directors, partners and, for any Person that is a limited liability company, that Person’s managers and members.

 

“Agent” means, MidCap, not in its individual capacity, but solely in its capacity as agent on behalf of and for the benefit of the Lenders.

 

“Agent-Related Person” means the Agent, together with its Affiliates, and the officers, directors, employees, agents, advisors, auditors and attorneys-in-fact of such Persons; provided, however, that no Agent-Related Person shall be an Affiliate of Borrower.

 

“Agreement” has the meaning given it in the preamble of this Agreement.

 

“Amortization Date” means August 1, 2013.

 

“Anti-Terrorism Laws” means any Laws relating to terrorism or money laundering, including Executive Order No. 13224 (effective September 24, 2001), the USA PATRIOT Act, the Laws comprising or implementing the Bank Secrecy Act, and the Laws administered by OFAC.

 

“Approved Drug” has the meaning given it in the definition of “Sale Compound”.

 

“Approved Fund” means any (a) investment company, fund, trust, securitization vehicle or conduit that is (or will be) engaged in making, purchasing, holding or otherwise investing in commercial loans and similar extensions of credit in the Ordinary Course of Business, or (b) any Person (other than a natural person) which temporarily warehouses loans for any Lender or any entity described in the preceding clause (a) and that, with respect to each of the preceding clauses (a) and (b), is administered or managed by (i) a Lender, (ii) an Affiliate of a Lender or (iii) a Person (other than a natural person) or an Affiliate of a Person (other than a natural person) that administers or manages a Lender.

 

“Assignment Agreement” has the meaning given it in Section 12.1.

 

“Blocked Person” means: (a) any Person listed in the annex to, or is otherwise subject to the provisions of, Executive Order No. 13224, (b) a Person owned or controlled by, or acting for or on behalf of, any Person that is listed in the annex to, or is otherwise subject to the provisions of, Executive Order No. 13224, (c) a Person with which any Lender is prohibited from dealing or otherwise engaging in any transaction by any Anti-Terrorism Law, (d) a Person that commits, threatens or conspires to commit or supports “terrorism” as defined in Executive Order No. 13224, or (e) a Person that is named a “specially designated national” or “blocked person” on the most current list published by OFAC or other similar list.

 

“Borrower” has the meaning given it in the preamble of this Agreement.

 

“Borrower’s Books” means all of Borrower’s books and records, including ledgers, federal and state tax returns, records regarding Borrower’s assets or liabilities, the Collateral, business operations or financial condition, and all computer programs or storage or any equipment containing such information.

 

“Borrowing Resolutions” means, with respect to any Person, those resolutions, in form and substance satisfactory to Agent, adopted by such Person’s Board of Directors or other appropriate governing body and delivered by such Person to Agent approving the Loan Documents to which such Person is a party and the transactions contemplated thereby, as well as any other approvals as may be necessary or desired to approve the entering into the Loan Documents or the consummation of the transactions contemplated thereby or in connection therewith.

 

  

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“Business Day” means any day that is not a Saturday, Sunday or a day on which Agent is closed for business.

 

“Cash Equivalents” means (a) marketable direct obligations issued or unconditionally guaranteed by the United States or any agency or any State thereof having maturities of not more than one (1) year from the date of acquisition, (b) commercial paper maturing no more than one (1) year after its creation and having the highest rating from either Standard & Poor’s Ratings Group or Moody’s Investors Service, Inc., (c) certificates of deposit issued maturing no more than one (1) year after issue, and (d) money market funds at least ninety-five percent (95%) of the assets of which constitute Cash Equivalents of the kinds described in clauses (a) through (b) of this definition.  For the avoidance of doubt, the direct purchase by Borrower, co-borrower, or any subsidiary of Borrower of any Auction Rate Securities, or purchasing participations in, or entering into any type of swap or other derivative transaction, or otherwise holding or engaging in any ownership interest in any type of Auction Rate Security by Borrower, co-borrower, or any subsidiary of Borrower shall be conclusively determined by the Lenders as an ineligible Cash Equivalent, and any such transaction shall expressly violate each other provision of this agreement governing Permitted Investments.  Notwithstanding the foregoing, Cash Equivalents does not include, and each Borrower and Subsidiary is prohibited from purchasing, purchasing participations in, entering into any type of swap or other equivalent derivative transaction, or otherwise holding or engaging in any ownership interest in any type of debt instrument, including, without limitation, any corporate or municipal bonds with a long-term nominal maturity for which the interest rate is reset through a dutch auction and more commonly referred to as an auction rate security.

 

“Change in Control” means any event, transaction, or occurrence as a result of which (a) any “person” (as such term is defined in Sections 3(a)(9) and 13(d)(3) of the Exchange Act), other than (i) a trustee or other fiduciary holding securities under an employee benefit plan of Borrower or (ii) Fred Eshelman, is or becomes, or has entered into a contract which upon consummation shall make such person, a beneficial owner (within the meaning Rule 13d-3 promulgated under the Exchange Act), directly or indirectly, of securities of Borrower, representing forty percent (40%) or more of the combined voting power of Borrower’s then outstanding securities; (b) any Borrower ceases to own, directly or indirectly, (100%) of the capital stock of any of its Subsidiaries; or (c) during any period of twelve consecutive calendar months, individuals who at the beginning of such period constituted the Board of Directors of Borrower (together with any new directors whose election by the Board of Directors of Borrower was approved by a vote of not less than two-thirds of the directors then still in office who either were directors at the beginning of such period  or whose election or nomination for election was previously so approved) cease for any reason other than death or disability to constitute a majority of the directors then in office.

 

“Claims” has the meaning given it in Section 12.2.

 

“Code” means the Uniform Commercial Code in effect on the date hereof, as the same may, from time to time, be enacted and in effect in the State of Maryland; provided, however, that to the extent that the Code is used to define any term herein or in any Loan Document and such term is defined differently in different Articles or Divisions of the Code, the definition of such term contained in Article or Division 9 shall govern; and provided, further, that in the event that, by reason of mandatory provisions of Law, any or all of the attachment, perfection, or priority of, or remedies with respect to, Agent’s Lien on any Collateral is governed by the Uniform Commercial Code in effect in a jurisdiction other than the State of Maryland, the term “Code” shall mean the Uniform Commercial Code as enacted and in effect in such other jurisdiction solely for purposes of the provisions thereof relating to such attachment, perfection, priority, or remedies and for purposes of definitions relating to such provisions.

“Collateral” means all property, now existing or hereafter acquired, mortgaged or pledged to, or purported to be subjected to a Lien in favor of Agent, for the benefit of Agent and Lenders, pursuant to this Agreement and the other Loan Documents, including, without limitation, all of the property described in Exhibit A hereto.

 

“Collateral Account” means any Deposit Account, Securities Account or Commodity Account.

 

“Commitment Percentage” means, as to any Lender, the percentage set forth opposite such Lender’s name on Schedule 1, as amended from time to time.

 

  

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“Commodity Account” means any “commodity account”, as defined in the Code, with such additions to such term as may hereafter be made.

 

“Communication” has the meaning given it in Section 10.

 

“Compliance Certificate” means a certificate, duly executed by an authorized officer of Borrower, appropriately completed and substantially in the form of Exhibit C.

 

“Contingent Obligation” means, for any Person, any direct or indirect liability, contingent or not, of that Person for (a) any indebtedness, lease, dividend, letter of credit or other obligation of another such as an obligation directly or indirectly guaranteed, endorsed, co-made, discounted or sold with recourse by that Person, or for which that Person is directly or indirectly liable; (b) any obligations for undrawn letters of credit for the account of that Person; and (c) all obligations from any interest rate, currency or commodity swap agreement, interest rate cap or collar agreement, or other agreement or arrangement designated to protect a Person against fluctuation in interest rates, currency exchange rates or commodity prices; but “Contingent Obligation” does not include endorsements in the Ordinary Course of Business.  The amount of a Contingent Obligation is the stated or determined amount of the primary obligation for which the Contingent Obligation is made or, if not determinable, the maximum reasonably anticipated liability for it determined by the Person in good faith; but the amount may not exceed the maximum of the obligations under any guarantee or other support arrangement.

 

“Control Agreement” means any control agreement entered into among the depository institution at which Borrower maintains a Deposit Account or the securities intermediary or commodity intermediary at which Borrower maintains a Securities Account or a Commodity Account, Borrower, and Agent pursuant to which Agent obtains control (within the meaning of the Code) for the benefit of the Lenders over such Deposit Account, Securities Account or Commodity Account.

 

“Credit Extension” means any Term Loan or any other extension of credit by Agent or the Lenders for Borrower’s benefit.

 

“DEA” means the Drug Enforcement Administration of the United States of America, and any successor agency thereof.

 

“Default” means any event which with notice or passage of time or both, would constitute an Event of Default.

 

“Default Rate” has the meaning given it in Section 2.3(c).

 

“Deposit Account” means any “deposit account” as defined in the Code with such additions to such term as may hereafter be made.

 

“Designated Deposit Account” means Borrower’s deposit account, account number [*], maintained with Silicon Valley Bank and over which Agent has been granted control for the ratable benefit of the Lenders.

“Development Compound” means any therapeutic compound being tested by any Borrower or any of its Subsidiaries, including without limitation, those drug compounds set forth on Schedule 5.11, for use in Phase I, Phase II or Phase III trials; provided, in the event Borrower fails to comply with the obligations under Section 6.2(d) to give notice to Agent and update Schedule 5.11 with respect to any new Development Compound, any such improperly undisclosed Development Compound shall be deemed to be included in this definition.

 

“Development Inventory” means the Borrower’s inventory of Development Compounds.

 

“Dollars,” “dollars” and “$” each means lawful money of the United States.

 

[*] Confidential treatment requested; certain information omitted and filed separately with the SEC.

 

  

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“Drug Application” means a new drug application, an abbreviated drug application, or a product license application for any Product, as appropriate, as those terms are defined in the FDCA.

 

“Eligible Assignee” means (a) a Lender, (b) an Affiliate of a Lender, (c) an Approved Fund, and (d) any other Person (other than a natural person) approved by Agent; provided, however, that notwithstanding the foregoing, “Eligible Assignee” shall not include Borrower, any Guarantor or any of Borrower’s or any Guarantor’s Affiliates or Subsidiaries.  Notwithstanding the foregoing, in connection with assignments by a Lender due to a forced divestiture at the request of any regulatory agency, the restrictions set forth herein shall not apply and Eligible Assignee shall mean any Person or party becoming an assignee incident to such forced divestiture.

 

“Equipment” means all “equipment”, as defined in the Code, with such additions to such term as may hereafter be made, and includes without limitation all machinery, fixtures, goods, vehicles (including motor vehicles and trailers), and any interest in any of the foregoing.

 

“ERISA” means the Employee Retirement Income Security Act of 1974, and all regulations promulgated thereunder.

 

“European Union” means the European Union and/or the countries that make up the European Union as of the Restatement Date.

 

“Event of Default” has the meaning given it in Section 8.

 

“Existing Agent” has the meaning given to it in the preamble to this Agreement.

 

“Existing Lenders” has the meaning given to it in the preamble to this Agreement.

 

“Existing Loan Agreement” has the meaning given to it in the preamble to this Agreement.

 

“FDA” means the Food and Drug Administration of the United States of America, or any successor entity thereto.

 

“FDCA” means the Federal Food, Drug and Cosmetic Act, as amended, 21 U.S.C. Section 301 et seq., and all regulations promulgated thereunder.

 

“Fee Letter” means that certain Fee Letter, dated as of the Restatement Closing Date by and among Borrower, Agent and the other parties thereto, as the same may be amended, restated, supplemented or otherwise modified from time to time.

 

“Final Payment” means a payment (in addition to and not a substitution for the regular monthly payments of principal plus accrued interest) due on the earlier to occur of (a) the Maturity Date, (b) the acceleration of any Term Loan, and (c) the prepayment of the Term Loan pursuant to Section 2.2(c) or (d), equal to the Term Loan Commitments multiplied by the Final Payment Percentage.

 

“Final Payment Percentage” means two and one half of one percent (2.5%).

 

“Foreign Subsidiary” means, with respect to any Person, a Subsidiary of such Person that is a “controlled foreign corporation” under Section 957 of the IRC.

 

“Funding Date” means any date on which a Credit Extension is made to or on account of Borrower which shall be a Business Day.

 

“GAAP” means generally accepted accounting principles set forth in the opinions and pronouncements of the Accounting Principles Board of the American Institute of Certified Public Accountants and statements and pronouncements of the Financial Accounting Standards Board or in such other statements by such other Person as may be approved by a significant segment of the accounting profession in the United States, which are applicable to the circumstances as of the date of determination.

 

  

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“General Intangibles” means all “general intangibles”, as defined in the Code, with such additions to such term as may hereafter be made, and includes without limitation, all copyright rights, copyright applications, copyright registrations and like protections in each work of authorship and derivative work, whether published or unpublished, any patents, trademarks, service marks and, to the extent permitted under applicable Law, any applications therefor, whether registered or not, any trade secret rights, including any rights to unpatented inventions, payment intangibles, royalties, contract rights, goodwill, franchise agreements, purchase orders, customer lists, route lists, telephone numbers, domain names, claims, income and other tax refunds, security and other deposits, options to purchase or sell real or personal property, rights in all litigation presently or hereafter pending (whether in contract, tort or otherwise), insurance policies (including without limitation key man, property damage, and business interruption insurance), payments of insurance and rights to payment of any kind.

 

“Global Reaffirmation Agreement” means that certain Omnibus Amendment and Reaffirmation Agreement, dated as of the Restatement Date, among Borrower and Agent, as the same may be amended, restated, replaced, supplemented or otherwise modified from time to time.

“Governmental Approval” means any consent, authorization, approval, order, license, franchise, permit, certificate, accreditation, registration, filing or notice, of, issued by, from or to, or other act by or in respect of, any Governmental Authority.

“Governmental Authority” means any nation or government, any state or other political subdivision thereof, any agency, authority, instrumentality, regulatory body, court, central bank or other entity exercising executive, legislative, judicial, taxing, regulatory or administrative functions of or pertaining to government, any securities exchange and any self-regulatory organization.

 

“Guarantor” means any present or future guarantor of the Obligations.

 

“Indebtedness” means (a) indebtedness for borrowed money or the deferred price of property or services, such as reimbursement and other obligations for surety bonds and letters of credit, (b) obligations evidenced by notes, bonds, debentures or similar instruments, (c) capital lease obligations, and (d) Contingent Obligations.

 

“Indemnified Liabilities” has the meaning given it in Section 12.2.

 

“Indemnified Person” has the meaning given it in Section 12.2.

 

“Insolvency Proceeding” means any proceeding by or against any Person under the United States Bankruptcy Code, or any other bankruptcy or insolvency Law, including assignments for the benefit of creditors, compositions, extensions generally with its creditors, or proceedings seeking reorganization, arrangement, or other relief.

 

“Intellectual Property” includes without limitation, all copyright rights, copyright applications, copyright registrations and like protections in each work of authorship and derivative work, whether published or unpublished, any patents, patent applications and like protections, including improvements, divisions, continuations, renewals, reissues, extensions, and continuations-in-part of the same, trademarks, trade names, service marks, mask works, rights of use of any name, domain names, or any other similar rights, any applications therefor, whether registered or not, know-how, operating manuals, trade secret rights, clinical and non-clinical data, rights to unpatented inventions,  and any claims for damage by way of any past, present, or future infringement of any of the foregoing.

 

“Inventory” means all “inventory”, as defined in the Code, with such additions to such term as may hereafter be made, and includes without limitation all merchandise, raw materials, parts, supplies, packing and shipping materials, work in process and finished products, including without limitation such inventory as is temporarily out of Borrower’s custody or possession or in transit and including any returned goods and any documents of title representing any of the above.

 

  

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“Investment” means any beneficial ownership interest in any Person (including stock, partnership interest or other securities), and any loan, advance or capital contribution to any Person.

 

“IRC” means the Internal Revenue Code of 1986.

 

“Laws” means any and all federal, state, provincial, territorial, local and foreign statutes, laws, judicial decisions, regulations, guidances, guidelines, ordinances, rules, judgments, orders, decrees, codes, plans, injunctions, permits, concessions, grants, franchises, governmental agreements and governmental restrictions, whether now or hereafter in effect, which are applicable to any Borrower in any particular circumstance.

 

“Lender” means any one of the Lenders.

 

“Lenders” means the Persons identified on Schedule 1 hereto, and each assignee that becomes a party to this Agreement pursuant to Section 12.1.

 

“Lenders’ Expenses” means all documented, out-of-pocket due diligence fees and expenses and other fees, costs, and expenses (including reasonable attorneys’ fees and expenses) of Agent and Lenders for preparing, amending, negotiating, administering, defending and enforcing this Agreement and the other Loan Documents (including, without limitation, those incurred in connection with appeals or Insolvency Proceedings) or otherwise incurred by Agent or the Lenders in connection with the Loan Documents.

 

“Lien” means a claim, mortgage, deed of trust, levy, charge, pledge, security interest or other encumbrance of any kind, whether voluntarily incurred or arising by operation of Law or otherwise against any property.

 

“Loan Documents” means, collectively, this Agreement, the Perfection Certificate, the Pledge Agreement, the Fee Letter, the Global Reaffirmation Agreement, the Secured Promissory Notes and any other note, or notes or guaranties executed by Borrower or any Guarantor in connection with the indebtedness governed by this Agreement, and any other present or future agreement between Borrower and/or for the benefit of the Lenders and Agent in connection with this Agreement, all as amended, restated, supplemented or otherwise modified.

 

“Loan Party” means Borrower and each Guarantor.

 

“Material Adverse Change” means (a) a material impairment in the perfection or priority of the Agent’s Lien in the Collateral or in the value of such Collateral, taken as a whole; (b) a material adverse change in the business, operations, or condition (financial or otherwise) or prospects of Borrower, taken as a whole; or (c) a material impairment of the prospect of repayment of any portion of the Obligations.

 

“Material Intellectual Property” means Borrower’s Intellectual Property and license agreements that are material to the condition (financial or other), business or operations of Borrower, as determined by Agent.  For purposes hereof, over the counter software that is commercially available to the public shall not be deemed “material.”

 

“Maturity Date” means August 2, 2016.

 

“Nesina” means the product containing the compound alogliptin as the only active pharmaceutical ingredient, which is used to treat Type 2 diabetes.

 

“Nesina Japan Sales” means the ‘Japan Net Sales’ as such term is defined in the Nesina License Agreement as in effect on the Restatement Date without giving effect to any future amendments, restatements, supplements or other modifications thereto.

 

“Nesina License Agreement” means that certain Agreement dated July 13, 2005 between Takeda San Diego, Inc. (“TSD”), Takeda Pharmaceutical Company Limited (“TPC”), Development Partners LLC (“PPD”) and Pharmaceutical Product Development, Inc. (“PPD, Inc.”), as amended by that certain Amendment No. 1 to the Agreement, dated as of October 10, 2005, by and among TSD, TPC, PPD and PPD, Inc.  Borrower hereby represents and warrants that, as of the Restatement Date, there are no other amendments, restatements, supplements or other modifications to the Nesina License Agreement other than as set forth in this definition.

 

  

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“[*] Permitted Transfer” means a [*] by [*] of certain [*] under the [*] by [*] solely with respect to [*] so long as (i) Borrower [*] of the [*] with respect to such [*] such [*].

 

“Obligations” means all of Borrower’s obligations to pay when due any debts, principal, interest, Lenders’ Expenses, the Prepayment Fee, the Final Payment, and other amounts Borrower owes the Lenders now or later, under this Agreement or the other Loan Documents, including, without limitation, interest accruing after Insolvency Proceedings begin (whether or not allowed) and debts, liabilities, or obligations of Borrower assigned to the Lenders and/or Agent, and the performance of Borrower’s duties under the Loan Documents.

 

“OFAC” means the U.S. Department of Treasury Office of Foreign Assets Control.

 

“OFAC Lists” means, collectively, the Specially Designated Nationals and Blocked Persons List maintained by OFAC pursuant to Executive Order No. 13224, 66 Fed. Reg. 49079 (Sept. 25, 2001) and/or any other list of terrorists or other restricted Persons maintained pursuant to any of the rules and regulations of OFAC or pursuant to any other applicable Executive Orders.

 

“Operating Documents” means, for any Person, (a) such Person’s formation documents, as certified with the Secretary of State of such Person’s state of formation on a date that is no earlier than 30 days prior to the Restatement Date, (b)(i) if such Person is a corporation, its bylaws in current form, (ii) if such Person is a limited liability company, its limited liability company agreement (or similar agreement), or (iii) if such Person is a partnership, its partnership agreement (or similar agreement), and (c) any other organizational documents of Borrower, in each case for clauses (a) through (c), together with all current amendments or modifications thereto and corporate, company, partner, member or shareholder resolutions associated therewith.

 

“Ordinary Course of Business” means, in respect of any transaction involving any Loan Party, the ordinary course of business of such Loan Party, as conducted by such Loan Party in accordance with past practices.

 

“Original Closing Date” has the meaning given it in the preamble of this Agreement.

 

“Payment/Advance Form” means that certain form attached hereto as Exhibit B.

 

“Payment Date” means the first calendar day of each calendar month.

 

“Perfection Certificate” has the meaning given it in Section 5.1.

 

“Permits” means licenses, certificates, accreditations, product clearances or approvals, provider numbers or provider authorizations, marketing authorizations, other authorizations, registrations, permits, consents and approvals required in connection with the conduct of Borrower’s or any Subsidiary’s business or to comply with any applicable Laws, including, without limitation, drug listings and drug establishment registrations under 21 U.S.C. Section 510, registrations issued by DEA under 21 U.S.C. Section 823 (if applicable to any Product), and those issued by State governments for the conduct of Borrower’s or any Subsidiary’s business.

 

“Permitted Indebtedness” means:

 

(a)           Borrower’s Indebtedness to the Lenders and Agent under this Agreement and the other Loan Documents;

 

(b)           Indebtedness existing on the Restatement Date and described on Schedule 7.4;

 

[*] Confidential treatment requested; certain information omitted and filed separately with the SEC.

 

  

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(c)           unsecured Indebtedness to trade creditors incurred in the Ordinary Course of Business;

 

(d)           Indebtedness secured by Permitted Liens; and

 

(e)           extensions, refinancings, modifications, amendments and restatements of any items of Permitted Indebtedness (a) through (d) above, provided, however, that the principal amount thereof is not increased or the terms thereof are not modified to impose more burdensome terms upon Borrower or its Subsidiary, as the case may be.

 

“Permitted Investments” means:

 

(a)           Investments existing on the Restatement Date and described on Schedule 7.7;

 

(b)           Investments consisting of Cash Equivalents; and

 

(c)           Investments in Subsidiaries that exist as of the Restatement Date and are Borrowers or that are otherwise created in accordance with Section 6.10 and subject to the terms thereof.

 

“Permitted IP Dispositions” has the meaning given it in Section 7.1.

 

“Permitted Liens” means:

 

(a)           Liens existing on the Restatement Date and shown on the Perfection Certificate or arising under this Agreement and the other Loan Documents;

 

(b)           Liens for taxes, fees, assessments or other government charges or levies, either not delinquent or being contested in good faith and for which Borrower maintains adequate reserves on its Books, provided, however, that no notice of any such Lien has been filed or recorded under the Internal Revenue Code of 1986, as amended , and the Treasury Regulations adopted thereunder;

 

(c)           purchase money Liens (i) on Equipment acquired or held by Borrower incurred for financing the acquisition of the Equipment securing no more than Two Hundred Fifty Thousand Dollars ($250,000) in the aggregate amount outstanding, or (ii) existing on Equipment when acquired, if the Lien is confined to the property and improvements and the proceeds of the Equipment;

 

(d)           statutory Liens securing claims or demands of materialmen, mechanics, carriers, warehousemen, landlords and other Persons imposed without action of such parties, provided, however, that they have no priority over any of Agent’s Lien and the aggregate amount of such Liens does not any time exceed Fifty Thousand Dollars ($50,000);

 

(e)           leases or subleases of real property granted in the Ordinary Course of Business, and leases, subleases, non-exclusive licenses or sublicenses of property (other than real property or Intellectual Property) granted in the Ordinary Course of Business, if the leases, subleases, licenses and sublicenses do not prohibit granting Agent a security interest;

 

(f)           banker’s liens, rights of setoff and Liens in favor of financial institutions incurred made in the Ordinary Course of Business arising in connection with Borrower’s deposit accounts or securities accounts held at such institutions to secure payment of fees and similar costs and expenses subject to Borrower’s compliance with Section 6.6(b) hereof;

 

(g)           Liens to secure payment of workers’ compensation, employment insurance, old-age pensions, social security and other like obligations incurred in the Ordinary Course of Business (other than Liens imposed by ERISA);

 

  

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(h)           Liens arising from judgments, decrees or attachments in circumstances not constituting an Event of Default under Section 8.5 or 8.7;

 

(i)            easements, reservations, rights-of-way, restrictions, minor defects or irregularities in title and similar charges or encumbrances affecting real property not constituting a Material Adverse Change;

 

(j)           non-exclusive licenses of Intellectual Property granted to third parties in the Ordinary Course of Business and/or Permitted IP Dispositions; and

 

(k)           Liens incurred in the extension, renewal or refinancing of the indebtedness secured by Liens described in (a) and (c) above, but any extension, renewal or replacement Lien must be limited to the property encumbered by the existing Lien and the principal amount of the Indebtedness may not increase.

 

“Person” means any individual, sole proprietorship, partnership, limited liability company, joint venture, company, trust, unincorporated organization, association, corporation, institution, public benefit corporation, firm, joint stock company, estate, entity or government agency.

 

“PPD” means PPD Development, LP, a Texas limited partnership.

 

“Prepayment Fee” means with respect to the Term Loan subject to prepayment prior to the Maturity Date, whether by mandatory or voluntary prepayment, acceleration or otherwise, an additional fee payable to the Lenders in amount equal to:

 

(a)           for a prepayment made on or after the Restatement Date through and including the date which is twelve (12)  months after the Restatement Date, four percent (4.0%) multiplied by the original Term Loan Commitments;

 

(b)           for a prepayment made after the date which is twelve (12) months after the Restatement Date through and including the date which is twenty-four (24)  months after the Restatement Date, three percent (3.0%)  multiplied by the original Term Loan Commitments; and

 

(c)           for a prepayment made after the date which is twenty-four (24) months after the Restatement Date through and including the date which is thirty-six (36) months after the Restatement Date, one percent (1.0%)  multiplied by the original Term Loan Commitments.

 

 “Pro Rata Share” means, as determined by Agent, with respect to each Lender, a percentage (expressed as a decimal, rounded to the ninth decimal place) determined by dividing the amount of Term Loans held by such Lender by the aggregate amount of all outstanding Term Loans.

 

“Products” means the Development Compounds and/or Sale Compounds.

 

 “Registered Organization” means any “registered organization” as defined in the Code, with such additions to such term as may hereafter be made.

 

“Required Lenders” means Lenders having (a) more than 60% of the Term Loan Commitments of all Lenders, or (b) if such Term Loan Commitments have expired or been terminated, more than 60% of the aggregate outstanding principal amount of the Term Loan; provided, however, that so long as a party that is a Lender hereunder on the Restatement Date does not assign any portion of its Term Loan Commitment or its portion of the Term Loan, the term “Required Lenders” shall include such Lender. For purposes of this definition only, a Lender shall be deemed to include itself, and any Lender that is an Affiliate or Approved Fund of such Lender.

 

“Required Permit” means a Permit (a) issued or required under Laws applicable to the business of Borrower or any of its Subsidiaries or necessary in the manufacturing, importing, exporting, possession, ownership, warehousing, marketing, promoting, sale, labeling, furnishing, distribution or delivery of goods or services under Laws applicable to the business of Borrower or any of its Subsidiaries or any Drug Application (including without limitation, at any point in time, all licenses, approvals and permits issued by the FDA or any other applicable Governmental Authority necessary for the testing of any Development Compound or the manufacture, marketing or sale of any Sale Compound by any applicable Borrower(s) as such activities are being conducted by such Borrower with respect to such Product at such time), and (b) issued by any Person from which Borrower or any of their Subsidiaries have received an accreditation.

 

  

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“Requirement of Law” means as to any Person, the organizational or governing documents of such Person, and any Law (statutory or common), treaty, rule or regulation or determination of an arbitrator or a court or other Governmental Authority, in each case applicable to or binding upon such Person or any of its property or to which such Person or any of its property is subject.

 

“Reserve Percentage” means, on any day, for any Lender, the maximum percentage prescribed by the Board of Governors of the Federal Reserve System (or any successor Governmental Authority) for determining the reserve requirements (including any basic, supplemental, marginal, or emergency reserves) that are in effect on such date with respect to eurocurrency funding (currently referred to as “eurocurrency liabilities”) of that Lender, but so long as such Lender is not required or directed under applicable regulations to maintain such reserves, the Reserve Percentage shall be zero.

 

“Responsible Officer” means any of the Chairman, President, Chief Medical Officer or Chief Financial Officer of Borrower.

 

“Restatement Date” has the meaning given to it in the preamble to this Agreement.

 

“Sale Compound” means any therapeutic compound approved for marketing (“Approved Drug”) that is manufactured, marketed or sold by any Borrower or any of its Subsidiaries, it being acknowledged and understood that as of the Restatement Date, neither Borrower nor any of its Subsidiaries manufactures and sells Approved Drugs; provided, in the event Borrower or its Subsidiaries engages in the manufacture or sale of Approved Drugs subsequent to the Restatement Date and Borrower fails to comply with the obligations under Section 6.2(d) to give notice to Agent and update Schedule 5.11 prior to manufacturing or selling any new Approved Drug, any such improperly undisclosed Approved Drug shall be deemed to be included in this definition.

 

 “Sale Inventory” means the inventory of Sale Compounds manufactured and held for sale by any Borrower or any of its Subsidiaries, including without limitation such inventory of Sale Compounds as is temporarily out of Borrower’s custody or possession or in transit and including any returned Sale Compounds inventory.

 

“Secretary’s Certificate” means, with respect to any Person, a certificate, in form and substance satisfactory to Agent, executed by such Person’s secretary on behalf of such Person certifying that (a) such Person has the authority to execute, deliver, and perform its obligations under each of the Loan Documents to which it is a party, (b) that attached as Exhibit A to such certificate is a true, correct, and complete copy of the Borrower Resolutions then in full force and effect authorizing and ratifying the execution, delivery, and performance by such Person of the Loan Documents to which it is a party, (c) the name(s) of the Person(s) authorized to execute the Loan Documents on behalf of such Person, together with a sample of the true signature(s) of such Person(s), and (d) that Agent and the Lenders may conclusively rely on such certificate unless and until such Person shall have delivered to Agent a further certificate canceling or amending such prior certificate.

 

“Secured Promissory Note” has the meaning given it in Section 2.7.

 

 “Secured Promissory Note Record” means a record maintained by each Lender with respect to the outstanding Obligations and credits made thereto.

 

 “Securities Account” means any “securities account”, as defined in the Code, with such additions to such term as may hereafter be made.

 

 “Subject Intellectual Property” has the meaning given it in Section 2.5(d).

 

  

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 “Subsidiary” means, with respect to any Person, any Person of which more than 50.0% of the voting stock or other equity interests (in the case of Persons other than corporations) is owned or controlled, directly or indirectly, by such Person or one or more of Affiliates of such Person.

 

“Takeda” means, either individually or collectively as the context may require, Takeda San Diego, Inc., a Delaware corporation and Takeda Pharmaceutical Company Limited, a company organized and existing under the laws of Japan.

 

“Term Loan” has the meaning given it in Section 2.2(a).

 

“Term Loan Commitment” means, for any Lender, the obligation of such Lender to fund a portion of the Term Loan, up to the principal amount shown on Schedule 1.  “Term Loan Commitments” means the aggregate amount of such commitments of all Lenders.

 

“Transfer” has the meaning given it in Section 7.1.

 

 

[SIGNATURES APPEAR ON FOLLOWING PAGE(S)]

 

  

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IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed as of the Restatement Date.

 

	 	
BORROWER:

	 
	 	 	 
	 	
FURIEX PHARMACEUTICALS, INC.

	 
	 	 	 	 
	
 

	
By: 

	/s/ Marshall Woodworth	 
	 	Name: Marshall Woodworth	 
	 	Title: Chief Financial Officer	 
	 	 	 	 
	 	 	 	 

	 	
APBI HOLDINGS, LLC

	 
	 	 	 	 
	
 

	
By: 

	/s/ Marshall Woodworth	 
	 	Name: Marshall Woodworth	 
	 	Title: Chief Financial Officer	 
	 	 	 	 
	 	 	 	 

	 	
DEVELOPMENT PARTNERS, LLC

	 
	 	 	 	 
	
 

	
By: 

	/s/ Marshall Woodworth	 
	 	Name: Marshall Woodworth	 
	 	Title: Chief Financial Officer	 
	 	 	 	 
	 	 	 	 

	 	
GENUPRO, INC.

	 
	 	 	 	 
	
 

	
By: 

	/s/ Marshall Woodworth 	 
	 	Name: Marshall Woodworth	 
	 	Title: Chief Financial Officer	 

 

 

 

FURIEX PHARMACEUTICALS, INC.

AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT

SIGNATURE PAGE

 

  

 

  

	 	
AGENT:

	 
	 	 	 
	 	
MIDCAP FUNDING III, LLC,

	 
	 	
as Agent for Lenders

	 
	 	 	 	 
	 	 	 	 
	
 

	
By: 

	/s/ Josh Groman 	 
	 	Name: Josh Groman	 
	 	Title: Managing Director	 

 

 

 

FURIEX PHARMACEUTICALS, INC.

AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT

SIGNATURE PAGE

 

  

  

  

 

	 	
LENDERS:

	 
	 	 	 
	 	
MIDCAP FUNDING III, LLC,

	 
	 	
as a Lender

	 
	 	 	 	 
	
 

	
By: 

	/s/ Josh Groman	 
	 	Name: Josh Groman	 
	 	Title: Managing Director	 
	 	 	 	 
	 	 	 	 
	 	
Address for notices:

 

MidCap Funding III, LLC

7255 Woodmont Avenue, Suite 200

Bethesda, Maryland 20814

Attention: Portfolio Management- Life Sciences

Fax:  (301) 941-1450

E-Mail: Lviera@midcapfinancial.com

 

with a copy to:

Midcap Financial, LLC

7255 Woodmont Avenue, Suite 200

Bethesda, Maryland 20814

Attention:  General Counsel

Fax:  (301) 941-1450

E-Mail: Rgoodridge@midcapfinancial.com

	 

 

 

 

FURIEX PHARMACEUTICALS, INC.

AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT

SIGNATURE PAGE

 

  

 

  

 

	 	MIDCAP FUNDING RE HOLDINGS, LLC,	 
	 	
as a Lender

	 
	 	 	 	 
	
 

	
By: 

	/s/ Josh Groman	 
	 	Name: Josh Groman	 
	 	Title: Managing Director	 
	 	 	 	 
	 	 	 	 
	 	
Address for notices:

 

Midcap Funding RE Holdings, LLC

7255 Woodmont Avenue, Suite 200

Bethesda, Maryland 20814

Attention: Portfolio Management- Life Sciences

Fax:  (301) 941-1450

E-Mail: Lviera@midcapfinancial.com

 

with a copy to:

Midcap Funding RE Holdings, LLC

7255 Woodmont Avenue, Suite 200

Bethesda, Maryland 20814

Attention:  General Counsel

Fax:  (301) 941-1450

E-Mail: Rgoodridge@midcapfinancial.com

	 

 

 

 

FURIEX PHARMACEUTICALS, INC.

AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT

SIGNATURE PAGE

 

  

  

  

	 	
SILICON VALLEY BANK,

	 
	 	
as a Lender

	 
	 	 	 	 
	 	
By: 

	/s/ Chris J. Stoecker	 
	 	Name: Chris J. Stoecker	 
	 	Title: SVP	 
	 	 	 	 
	 	 	 	 
	 	
Address for notices:

Silicon Valley Bank

3005 Carrington Mill Boulevard, Suite 530

Morrisville, North Carolina 27560

Attention: Chris Stoecker, Relationship Manager

Fax: (919) 461-3908

	 

 

 

 

FURIEX PHARMACEUTICALS, INC.

AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT

SIGNATURE PAGE

 

  

  

  

EXHIBITS AND SCHEDULES

 

EXHIBITS 

 

	Exhibit A	Collateral
	Exhibit B	Loan Payment / Advance Request Form
	Exhibit C	Compliance Certificate

 

SCHEDULES

 

	Schedule 1	Lenders and Commitments
	
Schedule 5.1

	
Organizational Information

	
Schedule 5.2

	Collateral Disclosures
	
Schedule 5.3

	Litigation
	
Schedule 5.11

	Products and Required Permits
	
Schedule 6.14

	
Post Closing Obligations

	
Schedule 7.4

	Indebtedness
	
Schedule 7.7

	Investments

 

  

 

  

 

EXHIBIT A

 

COLLATERAL

 

The Collateral consists of all assets of Borrower, including all of Borrower’s right, title and interest in and to the following personal property:

 

(a)           all goods, Accounts (including health-care insurance receivables), Equipment, Inventory, contract rights or rights to payment of money, leases, license agreements, franchise agreements, General Intangibles, commercial tort claims, documents, instruments (including any promissory notes), chattel paper (whether tangible or electronic), cash, deposit accounts, investment accounts, commodity accounts and other Collateral Accounts, all certificates of deposit, fixtures, letters of credit rights (whether or not the letter of credit is evidenced by a writing), securities, and all other investment property, supporting obligations, and financial assets, whether now owned or hereafter acquired, wherever located; and

 

(b)           all Borrower’s Books relating to the foregoing, and any and all claims, rights and interests in any of the above and all substitutions for, additions, attachments, accessories, accessions and improvements to and replacements, products, proceeds and insurance proceeds of any or all of the foregoing.

 

Notwithstanding the foregoing, the Collateral shall not include any Intellectual Property of any Loan Party, whether now owned or hereafter acquired, except to the extent that it is necessary under applicable law to have a Lien and security interest in any such Intellectual Property in order to have a perfected Lien and security interest in and to IP Proceeds (defined below), and for the avoidance of any doubt, the Collateral shall include, and Agent shall have a Lien and security interest in, (i) all IP Proceeds, and (ii) all payments with respect to IP Proceeds that are received after the commencement of a bankruptcy or insolvency proceeding.  The term “IP Proceeds” means, collectively, all cash, Accounts, license and royalty fees, claims, products, awards, judgments, insurance claims, and other revenues, proceeds or income, arising out of, derived from or relating to any Intellectual Property of any Loan Party, and any claims for damage by way of any past, present or future infringement of any Intellectual Property of any Loan Party (including, without limitation), all cash, royalty fees, other proceeds, Accounts and General Intangibles that consist of rights of payment to or on behalf of a Loan Party and the proceeds from the sale, licensing or other disposition of all or any part of, or rights in, any Intellectual Property by or on behalf of a Loan Party).

Agent and Lenders further acknowledge that the Collateral shall not include more than 65% of the voting securities of any Subsidiary that is not organized under the laws of the United States or any of its states if such pledge would cause a material increase in the Borrower’s federal income tax liability.

 

Pursuant to the terms of a certain negative pledge arrangement with Agent and Lenders, Borrower has agreed not to encumber any of its Intellectual Property without Agent’s and Lenders’ prior written consent.

 

  

 

  

 

EXHIBIT B

 

LOAN PAYMENT/ADVANCE REQUEST FORM

Deadline is Noon E.S.T.

 

Date: _________, 201_____

 

	 	 	 	 
	 	
LOAN PAYMENT:

	 	 
	 	 	 	 
	 	 From Account #________________________________	To Account #_________________________________	 
	 	                               (Deposit Account #)	                         (Loan Account #)	 
	 	 	 	 
	 	
Principal $____________________________________ and/or Interest $____________________________________________________

	 
	 	 	 	 
	 	
Authorized Signature: _______________________________

	Phone Number:                                                          	 
	 	
Print Name/Title: ____________________________________

	 	 
	 	 	 	 

 

 

	 	 	 	 
	 	Loan Advance:

 

Complete Outgoing Wire Request section below if all or a portion of the funds from this loan advance are for an outgoing wire.

	 
	 	 	 	 
	 	 From Account #________________________________	To Account #_________________________________	 
	 	                               (Loan Account #)	                         (Deposit Account #)	 
	 	 	 	 
	 	

Amount of Advance $___________________________

	 
	 	 	 	 
	 	
All Borrower’s representations and warranties in the Loan and Security Agreement are true, correct and complete in all material respects on the date of the request for an advance; provided, however, that such materiality qualifier shall not be applicable to any representations and warranties that already are qualified or modified by materiality in the text thereof; and provided, further, that those representations and warranties expressly  referring to a specific date shall be true, accurate and complete in all material respects as of such date:

	 
	 	 	 	 
	 	
Authorized Signature: ________________________________

	Phone Number:                                                          	 
	 	
Print Name/Title: _____________________________________

	 	 
	 	 	 	 

 

 

	 	 	 	 
	 	

Outgoing Wire Request:

 

Complete only if all or a portion of funds from the loan advance above is to be wired.

	 
	 	 	 	 
	 	Beneficiary Name: __________________________________________________	 Amount of Wire: $___________________________	 
	 	 	 	 
	 	Beneficiary Lender: _________________________________________________	Account Number: ____________________________	 
	 	
City and State: _______________________________________

	 
	 	 	 	 
	 	Beneficiary Lender Transit (ABA) #:                                  	Beneficiary Lender Code (Swift, Sort, Chip, etc.):                                  	 
	 	
(For International Wire Only)

	 	 
	 	 	 	 
	 	Intermediary Lender: ___________________________	Transit (ABA) #: ___________________________   	 
	 	
For Further Credit to: ________________________________________________________________________

	 
	 	 	 	 

 

  

  

  

 

	 	 	 	 
	 	Special Instruction: _________________________________________________________________________________________

By signing below, I (we) acknowledge and agree that my (our) funds transfer request shall be processed in accordance with and subject to the terms and conditions set forth in the agreements(s) covering funds transfer service(s), which agreements(s) were previously received and executed by me.

	 
	 	 	 	 
	 	

Authorized Signature: ____________________________

	
2nd Signature (if required): _________________________

	 
	 	
Print Name/Title: ________________________________

	
Print Name/Title: ________________________________

	 
	 	
Telephone #: ___________________________________

	
Telephone #: ___________________________________

	 
	 	 	 	 

 

  

  

  

 

EXHIBIT C

COMPLIANCE CERTIFICATE

 

	TO:	MidCap Funding III, LLC, as Agent
	FROM:	__________________________________
	DATE:	________________, 201__

 

The undersigned authorized officer of _________________________________________ (“Borrower”) certifies that under the terms and conditions of the Amended and Restated Loan and Security Agreement, dated August 2, 2012, between Borrower, Agent and the Lenders party thereto (as amended, restated, supplemented or otherwise modified from time to time, the “Agreement”):

 

(1)           Borrower is in complete compliance with all required covenants for the month ending _______________, 201__, except as noted below;

 

(2)           there are no Events of Default;

 

(3)           all representations and warranties in the Agreement are true and correct in all material respects on this date except as noted below; provided, however, that such materiality qualifier shall not be applicable to any representations and warranties that already are qualified or modified by materiality in the text thereof; and provided, further, that those representations and warranties expressly referring to a specific date shall be true, accurate and complete in all material respects as of such date;

 

(4)           Borrower, and each of its Subsidiaries, has timely filed all required tax returns and reports, and Borrower has timely paid all foreign, federal, state and local taxes, assessments, deposits and contributions owed by Borrower except as otherwise permitted pursuant to the terms of Section 5.8 of the Agreement; and

 

(5)           no Liens have been levied or claims made against Borrower or any of its Subsidiaries relating to unpaid employee payroll or benefits of which Borrower has not previously provided written notification to Agent.

 

Attached are the required documents supporting the certifications set forth in this Compliance Certificate.  The undersigned certifies, in his/her capacity as an officer of the Borrower, that these are prepared in accordance with GAAP consistently applied from one period to the next except as explained in an accompanying letter or footnotes.  The undersigned acknowledges, in his/her capacity as an officer of Borrower, that no borrowings may be requested at any time or date of determination that Borrower is not in compliance with any of the terms of the Agreement, and that compliance is determined not just at the date this certificate is delivered.  Capitalized terms used but not otherwise defined herein shall have the meanings given them in the Agreement.

 

Please indicate compliance status by circling Yes/No under “Complies” column.

 

	
Reporting Covenant

 

	
Required

	
Complies

	
Monthly Financial Statements

	
Monthly within 45 days

 

	
Yes          No

	
Audited Financial Statements

	
Annually within 150 days after FYE

 

	
Yes          No

	
Board Approved Projections

	
Annually within 90 days after FYE

 

	
Yes          No

	
Compliance Certificate

	
Monthly within 45 days

 

	
Yes          No

 

  

  

  

 

The following are the exceptions with respect to the certification above:  (If no exceptions exist, state “No exceptions to note.”)

 

	 
	 
	 

 

	
[NAME OF BORROWER]

 

 

By:                                                      

Name:                                                  

Title:                                                    

 

	
AGENT USE ONLY

 

Received by: ____________________

authorized signer

Date:           ______________________

 

Verified: ________________________

authorized signer

Date:           ______________________

 

Compliance Status:                  Yes        No

 

  

 

  

 

EXHIBIT D

 

FORM OF SECURED PROMISSORY NOTE

 

 

	$[___________]	[__________ __], 20[__]

 

FOR VALUE RECEIVED, FURIEX PHARMACEUTICALS, INC., a Delaware corporation, APBI HOLDINGS, LLC, a North Carolina limited liability company, DEVELOPMENT PARTNERS, LLC, a Delaware limited liability company, and GENUPRO, INC., a North Carolina corporation (either individually or collectively as the context may require, the “Borrower”) hereby promises to pay to the order of [_______________], or the holder of this Note (“Lender”) in care of MIDCAP FUNDING III, LLC, as agent under the Loan Agreement (as defined below), with an address of 7255 Woodmont Avenue, Suite 200, Bethesda, Maryland 20814, or such other place of payment as the holder of this Secured Promissory Note (this “Promissory Note”) may specify from time to time in writing, in lawful money of the United States of America, the principal amount of [__________] and No/100 Dollars ($[__________]), or such other principal amount as Lender has advanced to Borrower, together with interest in accordance with the Loan Agreement (as hereinafter defined) (or if and when applicable, at a rate equal to the Default Rate (as defined in the Loan Agreement) based upon a year consisting of 360 days, with interest computed daily based on the actual number of days in each month until the principal balance is paid in full.

 

This Promissory Note is executed and delivered in connection with that certain Amended and Restated Loan and Security Agreement of August 2, 2012 by and among Borrower, MidCap Funding III, LLC, as agent for Lenders, and Lender, and the other lenders named therein from time to time (as the same may from time to time be amended, modified, restated or supplemented in accordance with its terms, the “Loan Agreement”), and is entitled to the benefit and security of the Loan Agreement and the other Loan Documents (as defined in the Loan Agreement), to which reference is made for a statement of all of the terms and conditions thereof.  All payments shall be made in accordance with the Loan Agreement.  All terms defined in the Loan Agreement shall have the same definitions when used herein, unless otherwise defined herein.  An Event of Default under the Loan Agreement shall constitute a default under this Promissory Note, and upon any such Event of Default, all principal and interest and other obligations owing under this Promissory Note may be accelerated and declared immediately due and payable as provided for in the Loan Agreement.  Reference to the Loan Agreement shall not affect or impair the absolute and unconditional obligation of Borrower to pay all principal and interest and premium, if any, under this Promissory Note upon demand or as otherwise provided herein

 

Borrower waives presentment and demand for payment, notice of dishonor, protest and notice of protest under the Uniform Commercial Code as in effect in the State of Maryland or any applicable law.  Borrower agrees to make all payments under this Promissory Note without setoff, recoupment or deduction and regardless of any counterclaim or defense.  This Promissory Note has been negotiated and delivered to Lender and is payable in the State of Maryland.  This Promissory Note shall be governed by and construed and enforced in accordance with, the laws of the State of Maryland, excluding any conflicts of law rules or principles that would cause the application of the laws of any other jurisdiction.  Without limiting the generality of the preceding paragraph, the provisions of Section 11 of the Loan Agreement regarding jurisdiction, venue and jury trial waiver are incorporated herein.

 

 [SIGNATURES APPEAR ON THE FOLLOWING PAGE]

 

  

  

  

 

IN WITNESS WHEREOF, Borrower, as of the day and year first above written, has caused this Promissory Note to be executed under seal.

 

	 	
FURIEX PHARMACEUTICALS, INC.

	 
	 	 	 
	 	 	 
	 	By: ______________________________________ (SEAL)	 
	 	Name: __________________________________________	 
	 	Title: ___________________________________________	 

 

 

	 	
APBI HOLDINGS, LLC

	 
	 	 	 
	 	 	 
	 	By: ______________________________________ (SEAL)	 
	 	Name: __________________________________________	 
	 	Title: ___________________________________________	 

 

 

	 	
DEVELOPMENT PARTNERS, LLC

	 
	 	 	 
	 	 	 
	 	By: ______________________________________ (SEAL)	 
	 	Name: __________________________________________	 
	 	Title: ___________________________________________	 

 

 

	 	
GENUPRO, INC.

	 
	 	 	 
	 	 	 
	 	By: ______________________________________ (SEAL)	 
	 	Name: __________________________________________	 
	 	Title: ___________________________________________	 

 

 

 

FURIEX PHARMACEUTICALS, INC.

SECURED PROMISSORY NOTE ([LENDER])

SIGNATURE PAGE

 

  

 

  

 

SCHEDULE 1

LENDERS AND COMMITMENTS

	
Lender

 

	
Term Loan Commitment

	
Commitment Percentage

	
MidCap Funding III, LLC

	
 $10,000,000

	
25.00%

	
Midcap Funding RE Holdings, LLC

	
 $22,500,000

	
56.25%

	
Silicon Valley Bank

	
   $7,500,000

	
18.75%

	
TOTAL

	
 $40,000,000

	
   100%

 

  

 

  

 

SCHEDULE 5.1

 

ORGANIZATIONAL INFORMATION

 

 

	
Legal Name of Borrower

	
Type of Legal Entity

	
State of Organization

	
Organizational Identification Number

	
Tax Identification Number

	
Principal Place of Business

	
Furiex Pharmaceuticals, Inc.

	
Corporation

	
Delaware

	
4744208

	
27-1197863

	
3900 Paramount Parkway, Suite 150 

Morrisville, NC 27560

	
APBI Holdings, LLC

	
Limited Liability Company

	
North Carolina

	
0703248

	
N/A

	
3900 Paramount Parkway, Suite 150 

Morrisville, NC 27560

	
Development Partners, LLC

	
Limited Liability Company

	
Delaware

	
3728473

	
20-0417496

	
3900 Paramount Parkway, Suite 150 

Morrisville, NC 27560

	
GenuPro, Inc.

	
Corporation

	
North Carolina

	
0459382

	
56-2085866

	
3900 Paramount Parkway, Suite 150 

Morrisville, NC 27560

 

  

 

  

 

SCHEDULE 5.2(a)

 

COLLATERAL ACCOUNTS

 

Furiex Pharmaceuticals, Inc. maintains the following Deposit Accounts and Securities Accounts:

 

	
Bank Name

	
Account Number

	
Branch Address

	
Merrill Lynch

	
[*]

	
Raleigh, NC

	
Silicon Valley Bank

	
[*]

	
Santa Clara, CA

	
Silicon Valley Bank

	
[*]

	
Santa Clara, CA

	
Silicon Valley Bank

	
[*]

	
Santa Clara, CA

	
SVB Securities

	
[*]

	
Santa Clara, CA

 

 

[*] Confidential treatment requested; certain information omitted and filed separately with the SEC.

 

  

  

  

 

SCHEDULE 5.2(d)

INTELLECTUAL PROPERTY

 

	
[APPLIES TO ALL INTELLECTUAL PROPERTY AND LICENSE AGREEMENTS]

 

	
Borrower

	
Name / Identifier of IP or License

	
Type of IP (e.g., patent, TM, ©, mask work) or License Agreement

	
Expiration Date

(if a License, expiration of License and Licensed Property)

	
Furiex Pharmaceuticals, Inc.

	
Furiex website

	
Copyright

	
None

	
Furiex Pharmaceuticals, Inc.

	
FURIEX Reg. No. 813,150 (Canada)

	
Trademark

	
Renewal due 4/6/2020

	
Furiex Pharmaceuticals, Inc.

	
FURIEX App. No.  1039106 (China)

	
Trademark

	
Renewal due 5/12/2013

	
Furiex Pharmaceuticals, Inc.

	
FURIEX Reg. No. 009006024 (CTM)

	
Trademark

	
Renewal due 4/6/2020

	
Furiex Pharmaceuticals, Inc.

	
FURIEX and Design App. No. 009006164 (CTM)

	
Trademark

	
Renewal due 4/6/2020

	
Furiex Pharmaceuticals, Inc.

	
FURIEX Reg No. 301609083 (HK)

	
Trademark

	
Renewal due 5/9/2020

	
Furiex Pharmaceuticals, Inc.

	
FURIEX App. No. 2001938 (India)

	
Trademark

	
N/A

	
Furiex Pharmaceuticals, Inc.

	
FURIEX Reg. No. 1039106 (Japan)

	
Trademark

	
Renewal due 4/6/2020

	
Furiex Pharmaceuticals, Inc.

	
FURIEX App. No. 1088170 (Mexico)

	
Trademark

	
N/A

	
Furiex Pharmaceuticals, Inc.

	
FURIEX App. No. 1039106 (Norway)

	
Trademark

	
N/A

	
Furiex Pharmaceuticals, Inc.

	
FURIEX App. No.  1039106 (Russian Fed)

	
Trademark

	
Renewal due 5/12/2013

	
Furiex Pharmaceuticals, Inc.

	
FURIEX Reg. No. 1039106 (Switzerland)

	
Trademark

	
Renewal due 5/12/2020

	
Furiex Pharmaceuticals, Inc.

	
FURIEX Reg. No. 01450576 (Taiwan)

	
Trademark

	
Renewal due 11/23/2020

	
Furiex Pharmaceuticals, Inc.

	
FURIEX Reg. No. 3,881,579 (US)

	
Trademark

	
Renewal due 11/23/2020

	
Furiex Pharmaceuticals, Inc.

	
FURIEX and Design Reg. No. 3,881,578 (US)

	
Trademark

	
Renewal due 11/23/2020

	
Furiex Pharmaceuticals, Inc.

	
FURIEX Reg. No. 1039106 (WIPO)

	
Trademark

	
Renewal due 5/12/2020

	  
	
Furiex Pharmaceuticals, Inc.

	
MuDelta Development and License Agreement with Janssen Pharmaceutica, N.V.

	
License Agreement

	
Expires on a Product-by-Product and country-by-country basis until the date no further payment obligations of Payor to Payee relating to a Product are due.  At such time, all licenses granted to the Party Commercializing such Products under the Agreement in such country shall survive, but shall be non-exclusive, fully paid-up, and royalty-free.

  

  

  

 

	
[APPLIES TO ALL INTELLECTUAL PROPERTY AND LICENSE AGREEMENTS]

 

	
Borrower

	
Name / Identifier of IP or License

	
Type of IP (e.g., patent, TM, ©, mask work) or License Agreement

	
Expiration Date

(if a License, expiration of License and Licensed Property)

	
Furiex Pharmaceuticals, Inc.

	
TOPO Development and License Agreement with Janssen Pharmaceutica, N.V.

	
License Agreement

	
Expires on a Product-by-Product and country-by-country basis until the date no further payment obligations of Payor to Payee relating to a Product are due.  At such time, all licenses granted to the Party Commercializing such Products under the Agreement in such country shall survive, but shall be non-exclusive, fully paid-up, and royalty-free.

	
Furiex Pharmaceuticals, Inc.

	
License Agreement to Use EQ-5D-3L with Stichting EUROQOL Group

	
License Agreement

	
March 15, 2013

	
Genupro, Inc.

	
License Agreement to Use Priligy Know-How of Alza Corp. and Janssen Pharmaceutica NV

	
License and Asset Transfer Agreement

	
Perpetual license with no obligation to pay royalties or milestones. Exclusive license to make, use and sell Priligy and other dapoxetine-containing products. Non-exclusive license to make, use and sell dapoxetine-derivative products.

 

	
Name and Address of Licensor

	
Name and Date of License Agreement

	
Exclusive License? (Yes/No)

	
Restrictions to grant a lien, assign or sublicense?

(Yes/No)

	
Janssen Pharmaceutica, N.V.

Turnhoutseweg 30

2340 Beerse

Belgium

	
MuDelta Development and License Agreement

November 16, 2009

	
Yes

	
Yes

	
Janssen Pharmaceutica, N.V.

Turnhoutseweg 30

2340 Beerse

Belgium

	
TOPO Development and License Agreement

November 16, 2009

	
Yes

	
Yes

 

  

  

  

 

	
Name and Address of Licensor

	
Name and Date of License Agreement

	
Exclusive License? (Yes/No)

	
Restrictions to grant a lien, assign or sublicense?

(Yes/No)

	
Alza Corp.

700 Eubanks Drive

Vacaville, CA 95688; and Janssen Pharmaceutica NV

Turnhoutseweg 30

2340 Beerse

Belgium

	
License and Asset Transfer Agreement

July 30, 2012

	
Yes (to use licensed IP for certain uses)

	
Yes

	
GenuPro, Inc.

3900 Paramount Parkway

Suite 150

Morrisville, NC 27560

Berlin Chemie (Menarini Group)

Glienicker Weg 125

12489 Berlin

Germany

	
Priligy License Agreement

July 30, 2012

	
Yes

	
Yes

	
Xiamen Fuman Pharmaceuticals Co., Ltd

No. 55 Jintingbei Road

Jimei District

Xiamen

	
Patent License Contract

February 23, 2012

	
No

	
Yes

	
GenuPro, Inc.

3900 Paramount Parkway

Suite 150

Morrisville, NC 27560; and

Eli Lilly & Company

Lilly Corporate Center

Indianapolis, Indiana 46285

	
Termination and License Agreement

December 18, 2003

	
Yes

	
Yes

	
Stichting EUROQOL Group

3311 CR Dordrecht

Netherlands

	
License Agreement to Use EQ-5D-3L

March 15, 2010

	
No

	
Yes

Furiex has received a Petition for Invalidation of Korean Patent No. 719977 (entitled Methods of Using Rapid-Onset Selective Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction) that was filed with KIPO.  Patent counsel for Furiex is addressing this opposition and have engaged Korean patent counsel.

 

  

  

  

 

EXHIBIT 5.2(d)

PATENTS

[Updated July 27, 2012]

	
CO

 

	
Patent

Number

	
Serial No.

	
Issue

Date

	
Title

	
Estimated Expiration Date

	
Patents Owned by APBI Holdings, LLC

	
US

	
5,292,962

	
07/989,291

12/11/92

	
3/8/94

	
Intermediates to 1-phenyl-3-naphthalenyloxy-propanamines

	
[*]

	
Chile

	  	
1333/2004

5/31/2004

	  	
Methods of Using Rapid-Onset  Selective Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction

	
N/A

 

	
Japan

	
3,194,734

	
259000/2000

8/29/00

	
6/1/01

	
Methods of Using Rapid-Onset Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction

	
[*]

	
Malaysia

	
125490-A

	
PI 20003983

8/29/00

	
8/30/06

	
Methods of Using Rapid-Onset Selective Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction

	
[*]

	
Australia

	
762934

	
68911/00

8/22/00

	
10/30/03

	
Methods of Using Rapid-Onset Selective Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction

	
[*]

	
Bulgaria

	
BG65677

	
106.461

8/22/00

	
8/26/2009

	
Methods of Using Rapid-Onset Selective Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction

	
[*]

	
Brazil

	  	
PI0014166-6

8/22/00

 

	  	
Methods of Using Rapid-Onset Selective Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction

	
N/A

	
Brazil

	  	
PI0017554-4

8/22/00

	  	
Methods of Using Rapid-Onset Selective Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction

	
N/A

	
Canada

	
2,383,785

	
2,383,785

8/22/00

	
2/17/09

 

	
Methods of Using Rapid-Onset  Selective Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction

	
[*]

	
China

	
ZL 00815313.2

(announcement  no. CN 1222283)

	
00815313.2

8/22/00

	
10/12/2005

	
Methods of Using Rapid-Onset Selective Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction

	
[*]

	
Costa

Rica

	  	
6602

8/22/00

	  	
Methods of Using Rapid-Onset Selective Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction

	
N/A

	
Czech

Rep

	
299 712

	
PV2002-784

8/22/00

	
9/18/08

	
Use of Dapoxetine for Management of Sexual Dysfunction by Administering on an As-Needed Basis

	
[*]

	
Armenia

Azerbaijan

Belarus

Kazakhstan

Kyrgyzstan

Moldova

Russia

Tajikistan

Turkmenistan

	
004101

	
200200324

8/22/00

	
12/25/03

	
Use of a Rapid-Onset Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction

	
[*]

 

[*] Confidential treatment requested; certain information omitted and filed separately with the SEC.

 

  

  

  

 

	
CO

	
Patent

Number

	
Serial No.

	
Issue

Date

	
Title

	
Estimated Expiration Date

	
Estonia

	
05315

	
P200200107

8/22/00

	
9/7/10

	
Methods of Using Rapid-Onset Selective Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction

	
[*]

	
EPO

Albania

Austria

Belgium

Switzerland

Cyprus

Germany

Denmark

Spain

Finland

France

Greece

Ireland

Italy

Lithuania

Luxembourg

Latvia

Monaco

Macedonia

Netherlands

Portugal

Romania

Sweden

Slovenia

UK

	
1225881

 

German Patent No. 60026146.8-08

	
00957264.5

8/22/00

	
2/22/06

	
The Use of Dapoxetine, a Rapid-Onset Selective Serotonin Reuptake Inhibitor, for Treating Sexual Dysfunction

	
[*]

 

	
Austria

	
1225881

	
SZ 22/2009

7/10/09

	  	
The Use of Dapoxetine, a Rapid-Onset Selective Serotonin Reuptake Inhibitor, for Treating Sexual Dysfunction

	
[*]

	
Finland

	
1225881

	
C20090019  7/10/09

SPC Cert No. 252

	  	
The Use of Dapoxetine, a Rapid-Onset Selective Serotonin Reuptake Inhibitor, for Treating Sexual Dysfunction

	
[*]

	
Germany

	
1225881

	
12 2009 000 036.2

7/14/09

	  	
The Use of Dapoxetine, a Rapid-Onset Selective Serotonin Reuptake Inhibitor, for Treating Sexual Dysfunction

	
[*]

	
Italy

	
1225881

	
9/22/09

	  	
The Use of Dapoxetine, a Rapid-Onset Selective Serotonin Reuptake Inhibitor, for Treating Sexual Dysfunction

	
[*]

	
Portugal

	
1225881

	
20091000062783

6/30/09

	  	
The Use of Dapoxetine, a Rapid-Onset Selective Serotonin Reuptake Inhibitor, for Treating Sexual Dysfunction

	
[*]

	
Spain

	
1225881

	
C200900036

9/18/09

	  	
The Use of Dapoxetine, a Rapid-Onset Selective Serotonin Reuptake Inhibitor, for Treating Sexual Dysfunction

	
[*]

	
Sweden

	
1225881

	
587735

7/6/09

	  	
The Use of Dapoxetine, a Rapid-Onset Selective Serotonin Reuptake Inhibitor, for Treating Sexual Dysfunction

	
[*]

 

[*] Confidential treatment requested; certain information omitted and filed separately with the SEC.

 

  

  

  

 

	
CO

	
Patent

Number

	
Serial No.

	
Issue

Date

	
Title

	
Estimated Expiration Date

	
EPO divisional

	  	
06002333.0

8/22/00

 

	  	
Methods of Using Rapid-Onset Selective Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction

	
N/A

	
EPO divisional

	  	
07023209.5

8/22/00

 

	  	
Methods of Using Rapid-Onset Selective Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction

	
N/A

	
Hong Kong

	
HK1047545

	
02109124.8

8/22/00

	
9/22/06

	
The Use of Dapoxetine, A Rapid-Onset Selective Serotonin Reuptake Inhibitor, For Treating Sexual Dysfunction

	
[*]

	
Hong Kong

	  	
06113173.6

8/22/00

	  	
Methods of Using Rapid-Onset Selective Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction

	
N/A

	
Hong Kong

	  	
08105295.3

8/22/00

	  	
Methods of Using Rapid-Onset Selective Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction

	
N/A

	
Philippines

	
1-2000-002326

	
1-2000-002326

10/17/01

	
8/6/07

	
The Use of Dapoxetine, a Rapid-Onset Selective Serotonin Reuptake Inhibitor, for Treating Sexual Dysfunction

	
[*]

	
Hungary

	  	
P02 02687

8/22/00

	  	
Methods of Using Rapid-Onset Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction

	
N/A

	
Indonesia

	
ID 0 018 894

	
W-00 2002 00522

8/22/00

	
2/27/07

 

	
Methods of Using Rapid-Onset Selective Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction

	
[*]

	
Israel

	  	
148159

8/22/00

	  	
Use of dapoxetine or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the treatment or management of sexual  dysfunction

	
[*]

	
S. Korea

	
719977

	
10-2002-7002870

8/22/00

	
5/14/07

	
Methods of Using Rapid-Onset Selective Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction

	
[*]

	
S. Korea

	
719977

	
10-2009-0092209

9/29/09

	  	
Methods of Using Rapid-Onset Selective Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction

	
[*]

	
Mexico

	
236520

	
PA/A/2002/001811

8/22/00

	
5/4/06

	
Methods of Using Rapid-Onset Selective Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction

	
[*]

	
Norway

	
330562

	
20021035

8/22/00

	
5/16/11

	
Methods of Using Rapid-Onset Selective Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction

	
[*]

	
New Zealand

	
517038

	
517038

8/22/00

	
8/7/03

	
Methods of Using Rapid-Onset Selective Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction

	
[*]

	
Poland

	  	
P-364924

8/22/00

	  	
Methods of Using Rapid-Onset Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction

	
N/A

	
Singapore

	
87218

	
200200910-8

8/22/00

	
5/31/05

	
Methods of Using Rapid-Onset Selective Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction

	
[*]

	
Ukraine

	
75580

	
2002031755

8/22/00

	
5/15/06

	
Methods of Using Rapid-Onset Selective Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction

	
[*]

	
US

	
7,718,705

	
10/049,427

5/6/2002

	
5/18/10

	
Methods of Using Rapid-Onset Selective Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction

	
[*]

	
US

	  	
10/996,757

11/24/04

	  	
Methods of Using Rapid-Onset Selective Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction

	
N/A

 

[*] Confidential treatment requested; certain information omitted and filed separately with the SEC.

 

  

  

  

 

	
CO

	
Patent

Number

	
Serial No.

	
Issue

Date

	
Title

	
Estimated Expiration Date

	
South Africa

	
2002/1407

	
8/22/00

	
7/30/03

	
Methods of Using Rapid-Onset Selective Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction

	
[*]

	
Taiwan

	
I312678

	
089117155

8/25/00

	
8/1/2009

	
Pharmaceutical Composition Comprising Dapoxetine for Treating Sexual Dysfunction

	
[*]

	
Taiwan

	  	
094107594

8/25/00

	  	
Pharmaceutical Composition Comprising Rapid-Onset Selective Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction

	
[*]

	
Taiwan

	  	
098145182

	  	
Pharmaceutical Composition Comprising Rapid-Onset Selective Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction

	
N/A

	
Venezuela

	  	
2000-001911

8/29/00

	  	
Methods of Using Rapid-Onset  Selective Serotonin Reuptake Inhibitors for Treating Sexual Dysfunction

	
N/A

	
Patents Licensed to Furiex

	
Albania

	
 1675852

	
04783671.3

09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Albania

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Armenia

	
 200702039

	
02/Feb/2006

	
30/Jun/2010

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Argentina

	  	
P040103422

09/22/2004

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Argentina

	  	
P060101080

03/20/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Austria

	
1675852

	
04783671.3

09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Austria

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Australia

	
2004278320

	
09/09/2004

	
07/Oct/2010

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Australia

	  	
2006227984

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Azerbaijan

	
 200702039

	
02/Feb/2006

	
30/Jun/2010

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Bosnia-Herz

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Belgium

	
 

1675852

	
04783671.3

09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Belgium

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Bulgaria

	
 

1675852

	
04783671.3

09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Bulgaria

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

 

[*] Confidential treatment requested; certain information omitted and filed separately with the SEC.

 

  

  

  

 

	
CO

	
Patent

Number

	
Serial No.

	
Issue

Date

	
Title

	
Estimated Expiration Date

	
Brazil

	  	
PI0414573-9

09/09/2004

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Brazil

	  	
PI0609426-0

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Belarus

	
 200702039

	
02/Feb/2006

	
30/Jun/2010

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Canada

	  	
2539349

09/09/2004

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Canada

	  	
2602140

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Switz

	
 

1675852

	
04783671.3

09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Switz

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Chile

	
43.639

	
2394/04

09/20/2004

	
08/11/2008

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
PRC

	
200480033788.0

	
200480033788.0

09/09/2004

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
PRC

	
200680017405.X

 

	
200680017405.X

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Colombia

	  	
07099564

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Costa Rica

	  	
9458

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Cyprus

	
 

1675852

	
04783671.3

09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Cyprus

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Czech Rep

	
 

1675852

	
04783671.3

09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Czech Rep

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Germany

	
602004019555.3

	
04783671.3

09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Germany

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Denmark

	
1675852

	
04783671.3

09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Denmark

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Eurasia

	
200702039

	
02/02/2006

	
12/30/2010

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

 

[*] Confidential treatment requested; certain information omitted and filed separately with the SEC.

 

  

  

  

 

	
CO

	
Patent

Number

	
Serial No.

	
Issue

Date

	
Title

	
Estimated Expiration Date

	
Ecuador

	  	
07-7768

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Estonia

	
1675852

	
04783671.3

09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Estonia

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Egypt

	  	
989/2007

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
EPO

	
1675852

	
04783671.3

09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
EPO

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Spain

	
1675852

	
04783671.3

09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Spain

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Finland

	
1675852

	
04783671.3

09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Finland

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
France

	
1675852

	
04783671.3

09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
France

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
UK

	
1675852

	
04783671.3

09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
UK

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Greece

	
1675852

	
04783671.3

09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Greece

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Croatia

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Hungary

	
1675852

	
04783671.3

09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Hungary

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Indonesia

	  	
WO0200600776

09/09/2004

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

 

[*] Confidential treatment requested; certain information omitted and filed separately with the SEC.

 

  

  

  

 

	
CO

	
Patent

Number

	
Serial No.

	
Issue

Date

	
Title

	
Estimated Expiration Date

	
Indonesia

	
W00200703068

 

	
W00200703068

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Ireland

	
1675852

	
04783671.3

09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Ireland

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Israel

	  	
174397

09/09/2004

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Israel

	  	
186041

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
India

	
675/KOLNP/06

	
09/09/2004

	
10/Sep/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
India

	  	
4032/KOLNP/07

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Iceland

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Italy

	
1675852

	
04783671.3

09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Italy

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Japan

	  	
526944/06

09/09/2004

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Japan

	  	
502985/08

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Kirghizistan

	
 200702039

	
02/Feb/2006

	
30/Jun/2010

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
S Korea

	
10-2006-7007817

 

	
10-2006-7007817

09/09/2004

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
S Korea

	  	
10-2007-7024070

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Kazakhstan

	
 200702039

	
02/Feb/2006

	
30/Jun/2010

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Sri Lanka

	  	
PCT/US2006/003657

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Lithuania

	
1675852

	
04783671.3

09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Lithuania

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Luxembourg

	
1675852

	
04783671.3

09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Luxembourg

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Latvia

	
1675852

	
04783671.3

09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

 

[*] Confidential treatment requested; certain information omitted and filed separately with the SEC.

 

  

  

  

 

	
CO

	
Patent

Number

	
Serial No.

	
Issue

Date

	
Title

	
Estimated Expiration Date

	
Latvia

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Monaco

	
1675852

	
04783671.3

09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Monaco

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Moldova

	
 200702039

	
02/Feb/2006

	
30/Jun/2010

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Macedonia

	
04783671.3

P/EP-2009/70

	
04783671.3

09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Macedonia

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Malta

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Mexico

	
264642

	
PA/A/2006/003186

09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Mexico

	  	
MX/A/2007/011774

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Malaysia

	  	
PI20043865

09/21/2004

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Malaysia

	  	
PI20061247

03/21/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Nicaragua

	  	
2007/0243

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Netherlands

	
1675852

	
04783671.3

09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Netherlands

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Norway

	  	
20075385

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
New Zealand

	
545970

	
09/09/2004

	
10/Sep/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
New Zealand

	  	
561651

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Philippines

	  	
PCT/US2004/029523

09/09/2004

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Philippines

	  	
1-2007-502041

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Poland

	
1675852

	
04783671.3

09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Poland

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

 

[*] Confidential treatment requested; certain information omitted and filed separately with the SEC.

 

  

  

  

 

	
CO

	
Patent

Number

	
Serial No.

	
Issue

Date

	
Title

	
Estimated Expiration Date

	
Portugal

	
1675852

	
04783671.3

09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Portugal

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Romania

	
1675852

	
04783671.3

09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Romania

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Serbia

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Russia

	
 200702039

	
02/Feb/2006

	
30/Jun/2010

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Russia

	
 

2350615

	
2006109004

09/09/2004

	
03/27/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Sweden

	
1675852

	
04783671.3

09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Sweden

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Singapore

	
200708487-4

	
02/02/2006

	
31/Aug/2010

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Slovenia

	
1675852

	
04783671.3

09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Slovak Rep

	
1675852

	
04783671.3

09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Slovak Rep

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Tadjikistan

	
 200702039

	
02/Feb/2006

	
30/Jun/2010

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Turkmenistan

	
200702039

	
02/Feb/2006

	
30/Jun/2010

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Turkey

	
1675852

	
09/09/2004

	
02/18/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Turkey

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Taiwan

	  	
93128488

09/21/2004

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Taiwan

	  	
95109374

03/20/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Ukraine

	  	
a200710571

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
US

	
 

7179805

	
10/937238

09/09/2004

	
02/20/2007

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
US

	
 

7732612

	
11/084987

03/21/2005

	
08/Jun/2010

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
Vietnam

	  	
1-2007-01885

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

 

[*] Confidential treatment requested; certain information omitted and filed separately with the SEC.

 

  

  

  

 

	
CO

	
Patent

Number

	
Serial No.

	
Issue

Date

	
Title

	
Estimated Expiration Date

	
PCT

	  	
PCT/US2004/029523

09/09/2004

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
PCT

	  	
PCT/US2006/003657

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
N/A

	
Serbia/Montenegro

	  	
06720136.8

02/02/2006

	  	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	  
	
SA

	
2006/03223

	
09/09/2004

	
09/26/2007

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
SA

	
2007/08868

	
02/02/2006

	
01/28/2009

	
7-aminoakylidenyl-heterocyclic quinolones and napthyridones

	
[*]

	
US

	
7902227

	
12/180641

07/28/2008

	
08/Mar/2011

	
C-7 Isoxazolinyl Quinolone / Naphthyridine Derivatives Useful as Antibacterial Agents

	
[*]

	
US

	  	
60/952260

07/27/2007

	  	
C-7 Isoxazolinyl Quinolone / Naphthyridine Derivatives Useful as Antibacterial Agents

	
N/A

	
PCT

	  	
PCT/US2008/071294

07/28/2008

	  	
C-7 Isoxazolinyl Quinolone / Naphthyridine Derivatives Useful as Antibacterial Agents

	
N/A

	
US

	  	
12/426442

04/20/2009

	  	
Quinolone Derivatives Useful as Antibacterial Agents

	
N/A

	
US

	
7,994,206

	
12/168,331

07/07/2008

	
 8/9/2011

	
 Novel crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid

	
[*]

	
Australia

	  	
2008275270

07/07/2008

	  	
Novel crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid

	
N/A

	
Brazil

	  	
PI0813632-7

07/07/2008

	  	
Novel crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid

	
N/A

	
Canada

	  	
2695126

07/07/2008

	  	
 Novel crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid

	
N/A

	
China

	  	
20080024059.7

07/07/2008

	  	
Novel crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid

	
N/A

	
Colombia

	  	
10-000935

07/07/2008

	  	
Novel crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid

	
N/A

	
Costa Rica

	  	
N/A

07/07/2008

	  	
 Novel crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid

	
N/A

	
Eurasia

	  	
201070116

07/07/2008

	  	
Novel crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid

	
N/A

 

[*] Confidential treatment requested; certain information omitted and filed separately with the SEC.

 

  

  

  

 

	
CO

 

	
Patent

Number

	
Serial No.

	
Issue

Date

	
Title

	
Estimated Expiration Date

	
Ecuador

	  	
10-9863

07/07/2008

	  	
Novel crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid

	
N/A

	
Egypt

	  	
33/2010

07/07/2008

	  	
 Novel crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid

	
N/A

	
EP

	  	
08781434.9

07/07/2008

	  	
Novel crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid

	
N/A

	
Hong Kong

	  	
10107932.4

08/19/2010

	  	
Novel crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid

	
N/A

	
Indonesia

	  	
W00201000054

07/07/2008

	  	
 Novel crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid

	
N/A

	
Israel

	  	
203081

07/07/2008

	  	
Novel crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid

	
N/A

	
India

	  	
58/KOLNP/2010

07/07/2008

	  	
Novel crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid

	
N/A

	
Japan

	  	
516175/10

07/07/2008

	  	
 Novel crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid

	
N/A

	
South Korea

	  	
10-2010-7002535

07/07/2008

	  	
Novel crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid

	
N/A

	
Mexico

	  	
MX/A/2010/000323

07/07/2008

	  	
Novel crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid

	
N/A

	
Malaysia

	  	
PI2010000053

07/07/2008

	  	
 Novel crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid

	
N/A

	
Nicaragua

	  	
2010/0001

07/07/2008

	  	
Novel crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid

	
N/A

	
Norway

	  	
08781434.9

07/07/2008

	  	
Novel crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid

	
N/A

 

  

  

  

 

	
CO

 

	
Patent

Number

	
Serial No.

	
Issue

Date

	
Title

	
Estimated Expiration Date

	
New Zealand

	  	
582420

07/07/2008

	  	
 Novel crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid

	
N/A

	
Philippines

	  	
10-2010-500060

07/07/2008

	  	
Novel crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid

	
N/A

	
Singapore

	  	
201000095-8

07/07/2008

	  	
Novel crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid

	
N/A

	
Ukraine

	  	
201001286

07/07/2008

	  	
 Novel crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid

	
N/A

	
United States

	  	
12/168,331

07/07/2008

	  	
Novel crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid

	
N/A

	
Vietnam

	  	
1-2009-02869

07/07/2008

	  	
Novel crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid

	
N/A

	
United States

	  	
PCT/US2008/069318

07/07/2008

	  	
 Novel crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid

	
N/A

	
South Africa

	
2010/0921

	
2010/0921

07/07/2008

	
4/28/2011

	
Novel crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid

	
[*]

	
Argentina

	  	
P090104133

10/27/2009

	  	
Process for the Preparation of Protected L-Alanine Derivatives

	
N/A

	
Taiwan

	  	
98136147

10/26/2009

	  	
Process for the Preparation of Protected L-Alanine Derivatives

	
N/A

	
US

	  	
12/606,730

10/27/2009

	  	
Process for the Preparation of Protected L-Alanine Derivatives

	
N/A

	
Australia

	
2009233679

 

	
2009233679

11/05/2009

	
9/8/2011

	
 Compounds as Opioid Receptor Modulators

	
[*]

	
Australia

	  	
2011202364

5/20/2011

	  	
 Compounds as Opioid Receptor Modulators

	
N/A

	
Brazil

	  	
PI0309708-0

04/17/2003

	  	
 Compounds as Opioid Receptor Modulators

	
N/A

	
Canada

	
2483662

	
2483662

04/17/2003

	  	
 Compounds as Opioid Receptor Modulators

	
[*]

	
PRC

	
ZL03815199.5

	
200810086599

04/17/2003

	
 10/6/2012

	
Compounds as Opioid Receptor Modulators

	
[*]

 

[*] Confidential treatment requested; certain information omitted and filed separately with the SEC.

 

  

  

  

 

	
CO

	
Patent

Number

	
Serial No.

	
Issue

Date

	
Title

	
Estimated Expiration Date

	
PRC

	  	
3815200

04/17/2003

	  	
 Compounds as Opioid Receptor Modulators

	
[*]

	
Colombia

	
4120039

 

	
4120039

04/17/2003

	  	
 Compounds as Opioid Receptor Modulators

	
[*]

	
Colombia

	
04120039A

	
04120039A

2/13/2009

	
6/25/2010

	
Compounds as Opioid Receptor Modulators

	
[*]

	
Colombia

	
04120039B

	
04120039B

2/13/2009

	
8/28/2010

	
 Compounds as Opioid Receptor Modulators

	
[*]

	
Colombia

	  	
04120039C

2/13/2009

	  	
Compounds as Opioid Receptor Modulators

	
N/A

	
EPO

	
1499313

	
3719806

04/17/2003

	
 07/07/2011

	
 Compounds as Opioid Receptor Modulators

	
[*]

	
EPO

	  	
10180687.5

4/17/2003

	  	
Compounds as Opioid Receptor Modulators

	
N/A

	
Hong Kong

	  	
11107444.4

7/18/2011

	  	
Compounds as Opioid Receptor Modulators

	
N/A

	
Croatia

	  	
P20041014

04/17/2003

	  	
Compounds as Opioid Receptor Modulators

	
N/A

	
Indonesia

	  	
W00200703271

04/17/2003

	  	
 Compounds as Opioid Receptor Modulators

	
N/A

	
Indonesia

	
P0028365

	
W00200402406

04/17/2003

	
 05/26/2011

	
 Compounds as Opioid Receptor Modulators

	
[*]

	
Israel

	  	
197642

04/17/2003

	  	
 Compounds as Opioid Receptor Modulators

	
N/A

	
Israel

	
164910

	
164910

04/17/2003

	
 11/1/2011

	
Compounds as Opioid Receptor Modulators

	
[*]

	
India

	  	
853/KOLNP/08

04/17/2003

	  	
 Compounds as Opioid Receptor Modulators

	
N/A

	
India

	
1727/KOLNP/04

	
04/17/2003

	
 07/23/2008

	
 Compounds as Opioid Receptor Modulators

	
[*]

	
Japan

	  	
500872/04

04/17/2003

	  	
 Compounds as Opioid Receptor Modulators

	
N/A

	
S Korea

	  	
10-2004-7017395

04/17/2003

	  	
Compounds as Opioid Receptor Modulators

	
N/A

	
Sri Lanka

	  	
US03/11872

04/17/2003

	  	
 Compounds as Opioid Receptor Modulators

	
N/A

	
Mexico

	  	
MX/A/2007/013630

04/17/2003

	  	
 Compounds as Opioid Receptor Modulators

	
N/A

	
Mexico

	
253361

	
PA/A/2004/011947

04/17/2003

	
01/14/2008

	
 Compounds as Opioid Receptor Modulators

	
[*]

	
Norway

	  	
20045159

04/17/2003

	  	
Compounds as Opioid Receptor Modulators

	
N/A

 

[*] Confidential treatment requested; certain information omitted and filed separately with the SEC.

 

  

  

  

 

	
CO

	
Patent

Number

	
Serial No.

	
Issue

Date

	
Title

	
Estimated Expiration Date

	
New Zealand

	
561795

	
04/17/2003

	
08/13/2009

	
 Compounds as Opioid Receptor Modulators

	
[*]

	
New Zealand

	  	
575640

04/17/2003

	  	
 Compounds as Opioid Receptor Modulators

	
N/A

	
Philippines

	
1-2004-501742

	
04/17/2003

	
 09/22/2009

	
 Compounds as Opioid Receptor Modulators

	
[*]

	
Poland

	  	
374053

04/17/2003

	  	
Compounds as Opioid Receptor Modulators

	
N/A

	
Poland

	  	
374053

	
9/22/2009

	
Compounds as Opioid Receptor Modulators

	
N/A

	
Russia

	
 

2332411

	
2004131829

04/17/2003

	
08/27/2008

	
 Compounds as Opioid Receptor Modulators

	
[*]

	
Singapore

	
200406282-4

	
04/17/2003

	
11/30/2006

	
 Compounds as Opioid Receptor Modulators

	
[*]

	
Ukraine

	  	
200902108

04/17/2003

	  	
 Compounds as Opioid Receptor Modulators

	
N/A

	
Ukraine

	
20041109807

 

	
20041109807

04/17/2003

	
 09/10/2009

	
Compounds as Opioid Receptor Modulators

	
[*]

	
US

	
 

7,041,681

	
10/400,006

03/26/2003

	
 05/09/2006

	
 Compounds as Opioid Receptor Modulators

	
[*]

	
US

	
 

7,202,381

	
11/079,573

03/14/2005

	
 04/10/2007

	
 Compounds as Opioid Receptor Modulators

	
[*]

	
US

	
7,659,402

	
11/242,763

10/04/2005

	
 02/09/2010

	
 Compounds as Opioid Receptor Modulators

	
[*]

	
PCT

	  	
PCT/US2003/11872

04/17/2003

	  	
Compounds as Opioid Receptor Modulators

	
N/A

	
SA

	
2004/9554

	
04/17/2003

	
07/26/2006

	
Compounds as Opioid Receptor Modulators

	
[*]

	
Argentina

	  	
P050101007

03/15/2005

	  	
Compounds as Opioid Receptor Modulators

	
N/A

	
Australia

	
2005224091

	
2005224091

03/15/2005

	
 5/17/2012

	
Compounds as Opioid Receptor Modulators

	
[*]

	
Brazil

	  	
2005224091

03/15/2005

	  	
Compounds as Opioid Receptor Modulators

	
N/A

	
Canada

	  	
2560047

03/15/2005

	  	
Compounds as Opioid Receptor Modulators

	
N/A

	
Chile

	  	
2005-0557

03/15/2005

	  	
Compounds as Opioid Receptor Modulators

	
N/A

	
 PRC

	  	
200580014571.X

03/15/2005

	  	
 Compounds as Opioid Receptor Modulators

	
N/A

	
Colombia

	  	
6093425

03/15/2005

	  	
Compounds as Opioid Receptor Modulators

	
N/A

	
Costa Rica

	  	
8655

03/15/2005

	  	
 Compounds as Opioid Receptor Modulators

	
N/A

	
Eurasia

	  	
PCT/US2005/008339

03/15/2005

	  	
 Compounds as Opioid Receptor Modulators

	
N/A

 

[*] Confidential treatment requested; certain information omitted and filed separately with the SEC.

 

  

  

  

 

	
CO

	
Patent

Number

	
Serial No.

	
Issue

Date

	
Title

	
Estimated Expiration Date

	
Ecuador

	  	
SP-06-6856

03/15/2005

	  	
 Compounds as Opioid Receptor Modulators

	
N/A

	
Egypt

	  	
861/2006

03/15/2005

	  	
Compounds as Opioid Receptor Modulators

	
N/A

	
EPO

	
1725537

	
5728171.9

03/15/2005

	
 07/13/2011

	
 Compounds as Opioid Receptor Modulators

	
[*]

	
HK

	
HK1099016

	
7105593

03/15/2005

	
 5/4/2012

	
 Compounds as Opioid Receptor Modulators

	
[*]

	
HK

	  	
7111210

03/15/2005

	  	
 Compounds as Opioid Receptor Modulators

	
N/A

	
Indonesia

	  	
W00200602542

03/15/2005

	  	
Compounds as Opioid Receptor Modulators

	
N/A

	
Israel

	  	
178040

03/15/2005

	  	
 Compounds as Opioid Receptor Modulators

	
N/A

	
India

	  	
2981/KOLNP/06

03/15/2005

	  	
 Compounds as Opioid Receptor Modulators

	
N/A

	
Japan

	
4778954

	
503986/07

03/15/2005

	
 07/08/2011

	
Compounds as Opioid Receptor Modulators

	
[*]

	
S Korea

	  	
10-2006-7021231

03/15/2005

	  	
 Compounds as Opioid Receptor Modulators

	
N/A

	
Sri Lanka

	  	
PCT/US2005/008339

03/15/2005

	  	
 Compounds as Opioid Receptor Modulators

	
N/A

	
Mexico

	  	
PA/A/2006/010642

03/15/2005

	  	
 Compounds as Opioid Receptor Modulators

	
N/A

	
Malaysia

	  	
PI20051060

03/15/2005

	  	
Compounds as Opioid Receptor Modulators

	
N/A

	
Nicaragua

	  	
PCT/US2005/008339

03/15/2005

	  	
 Compounds as Opioid Receptor Modulators

	
N/A

	
Norway

	  	
20064660

03/15/2005

	  	
 Compounds as Opioid Receptor Modulators

	
N/A

	
New Zealand

	  	
549842

03/15/2005

	  	
Compounds as Opioid Receptor Modulators

	
N/A

	
Philippines

	  	
1-2006-501823

03/15/2005

	  	
 Compounds as Opioid Receptor Modulators

	
N/A

	
Singapore

	
125535

	
200606297-0

03/15/2005

	
03/31/2009

	
 Compounds as Opioid Receptor Modulators

	
[*]

	
Taiwan

	  	
94107612

03/15/2005

	  	
 Compounds as Opioid Receptor Modulators

	
N/A

	
Ukraine

	
86053

	
A200609824

	
03/25/2009

	
Compounds as Opioid Receptor Modulators

	
[*]

	
US

	
 

7,741,356

	
11/079,647

03/14/2005

	
 6/22/10

	
 Compounds as Opioid Receptor Modulators

	
[*]

 

[*] Confidential treatment requested; certain information omitted and filed separately with the SEC.

 

  

  

  

 

	
CO

	
Patent

Number

	
Serial No.

	
Issue

Date

	
Title

	
Estimated Expiration Date

	
US

	
 

7,786,158

	
11/877,747

10/24/2007

	
 8/31/10

	
 Compounds as Opioid Receptor Modulators

	
[*]

	
US

	  	
12/838,825

	
11/22/11

	
Compounds as Opioid Receptor Modulators

	
N/A

	
VIETNAM

	  	
1-2006-01521

	  	
 Compounds as Opioid Receptor Modulators

	
N/A

	
PCT

	  	
PCT/US2005/008339

03/14/2005

	  	
Compounds as Opioid Receptor Modulators

	
N/A

	
SA

	
2006/8587

	  	
01/30/2008

	
 Compounds as Opioid Receptor Modulators

	
[*]

	
United Arab Emirates

	  	
405/2011

10/27/2009

	  	
PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES

	
N/A

	
Argentina

	  	
P0104133

10/27/2009

	  	
PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES

	
N/A

	
Australia

	  	
2009320156

10/27/2009

	  	
PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES

	
N/A

	
Brazil

	  	
P10920834-8

10/27/2009

	  	
PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES

	
N/A

	
Canada

	  	
2741790

10/27/2009

	  	
PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES

	
N/A

	
Chile

	  	
936/11

10/27/2009

	  	
PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES

	
N/A

	
PRC

	  	
200980153642.2

10/27/2009

	  	
PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES

	
N/A

	
Columbia

	  	
11051582

10/27/2009

	  	
PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES

	
N/A

	
Costa Rica

	  	
N/A

	  	
PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES

	
N/A

	
Eurasia Patent Convention

	  	
201170618

10/27/2009

	  	
PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES

	
N/A

	
Ecuador

	  	
SP-11-011008

10/27/2009

	  	
PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES

	
N/A

	
Egypt

	  	
N/A

	  	
PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES

	
N/A

	
European Patent Convention

	  	
09752026.6

10/27/2009

	  	
PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES

	
N/A

	
Honduras

	  	
2011-001186

10/27/2009

	  	
PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES

	
N/A

	
Indonesia

	  	
WO201101496

10/27/2009

	  	
PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES

	
N/A

	
Israel

	  	
212464

10/27/2009

	  	
PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES

	
N/A

 

[*] Confidential treatment requested; certain information omitted and filed separately with the SEC.

 

  

  

  

 

	
CO

	
Patent

Number

	
Serial No.

	
Issue

Date

	
Title

	
Estimated Expiration Date

	
India

	  	
1699/KOLNP/2011

10/27/2009

	  	
PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES

	
N/A

	
Japan

	  	
2011-534675

10/27/2009

	  	
PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES

	
N/A

	
S. Korea

	  	
10-2011-7011699

10/27/2009

	  	
PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES

	
N/A

	
Mexico

	  	
MX/A/2011/004393

10/27/2009

	  	
PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES

	
N/A

	
Nicaragua

	  	
2011-000078

10/27/2009

	  	
PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES

	
N/A

	
New Zealand

	  	
592415

10/27/2009

	  	
PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES

	
N/A

	
Peru

	  	
939

10/27/2009

	  	
PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES

	
N/A

	
Philippines

	  	
1-2011-500818

10/27/2009

	  	
PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES

	
N/A

	
Singapore

	  	
201102907-1

10/27/2009

	  	
PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES

	
N/A

	
Taiwan

	  	
98136147

10/27/2009

	  	
PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES

	
N/A

	
Ukraine

	  	
201106621

10/27/2009

	  	
PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES

	
N/A

	
United States

	  	
61/108,649

10/27/2009

	  	
PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES

	
N/A

	
US

	  	
12/606,730

10/27/2009

	  	
PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES

	
N/A

	
PCT

	  	
WO/2010062590

10/27/2009

	  	
PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES

	
N/A

	
South Africa

	  	
2011/03881

10/27/2009

	  	
PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES

	
N/A

	
Armenia

	
015512

	
200701978

3/6/2006

	
8/30/2011

	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	  
	
Armenia

	
014366

	
200701979

3/6/2006

	
10/29/2010

	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
[*]

	
Argentina

	  	
P060100973

3/14/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
Australia

	  	
2006223394

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
Azerbaijan

	
015512

	
200701978

3/6/2006

	
8/30/2011

	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
[*]

 

[*] Confidential treatment requested; certain information omitted and filed separately with the SEC.

 

  

  

  

 

	
CO

	
Patent

Number

	
Serial No.

	
Issue

Date

	
Title

	
Estimated Expiration Date

	
Azerbaijan

	
014366

	
200701979

3/6/2006

	
10/29/2010

	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
[*]

	
Brazil

	  	
PI0607793-5

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
Brazil

	  	
PI0607792-7

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
Belarus

	
015512

	
200701978

3/6/2006

	
8/30/2011

	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
[*]

	
Belarus

	
014366

	
200701979

3/6/2006

	
10/29/2010

	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
[*]

	
Canada

	  	
2601481

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
Canada

	  	
2601674

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
Chile

	  	
0570/06

3/14/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
China, People Republic

	
ZL200680016371.2

	
200680016371.2

3/6/2006

	
2/2/2011

	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
[*]

	
Colombia

	  	
07095843

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
Costa Rica

	  	
9438

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
Costa Rica

	  	
9437

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
Eurasian Procedure

	
015512

	
200701978

3/6/2006

	
8/30/2011

	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
[*]

	
Eurasian Procedure

	
014366

	
200701979

3/6/2006

	
10/29/2010

	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
[*]

	
Ecuador

	  	
07-7737

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
Ecuador

	  	
07-7738

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
Egypt

	  	
PCT963/2007

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
Egypt

	  	
PCT/962/2007

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
European Procedure

	  	
06737611.1

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
European Procedure

	  	
06737413.2

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

 

[*] Confidential treatment requested; certain information omitted and filed separately with the SEC.

 

  

  

  

 

	
CO

	
Patent

Number

	
Serial No.

	
Issue

Date

	
Title

	
Estimated Expiration Date

	
Hong Kong

	  	
08106447.8

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
Indonesia

	  	
W00201004600

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
Indonesia

	  	
WO021014599

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
Indonesia

	  	
W00201004601

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
Indonesia

	  	
W00200702971

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
Indonesia

	
ID0027689

	
W00200702972

3/6/2006

	
3/03/2011

	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
[*]

	
Israel

	  	
209402

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
Israel

	  	
185972

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
India

	  	
3419/KOLNP/07

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
India

	  	
3420/KOLNP/07

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
Japan

	  	
501919/08

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
Japan

	  	
501912/08

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
Kirghizistan

	  	
200701978

015512

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
Kirghizistan

	  	
200701979

014366

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
S. Korea

	  	
10-2007-7022664

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
S. Korea

	  	
10-2007-7023282

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
 

Kazakhstan

	
015512

	
200701978

3/6/2006

	
8/30/2011

	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
[*]

	
Kazakhstan

	
014366

	
200701979

3/6/2006

	
10/29/2010

	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
[*]

	
Sri Lanka

	  	
PCT/US2006/008450

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
Sri Lanka

	  	
PCT/US2006/008240

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

 

[*] Confidential treatment requested; certain information omitted and filed separately with the SEC.

 

  

  

  

 

	
CO

	
Patent

Number

	
Serial No.

	
Issue

Date

	
Title

	
Estimated Expiration Date

	
Moldova Republic

	
015512

	
200701978

3/6/2006

	
8/30/2011

	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
[*]

	
Moldova Republic

	
014366

	
200701979

3/6/2006

	
10/29/2010

	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
[*]

	
Mexico

	  	
MX/A/2007/011412

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
Malaysia

	  	
PI200611103/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
Nicaragua

	  	
2007-000237

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
Nicaragua

	  	
2007-000238

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
Norway

	  	
PCT/US2006/008450

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
Norway

	  	
20075268

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
New Zealand

	  	
590570

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
New Zealand

	  	
561440

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
New Zealand

	  	
561439

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
Philippines

	  	
1-2007-502013

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
Russian Federation

	
015512

	
200701978

3/6/2006

	
8/30/2011

	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
[*]

	
Russian Federation

	
014366

	
200701979

3/6/2006

	
10/29/2010

	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
[*]

	
Tadjikistan

	
015512

	
200701978

3/6/2006

	
8/30/2011

	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
[*]

	
Tadjikistan

	
014366

	
200701979

3/6/2006

	
10/29/2010

	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
[*]

	
Turkmenistan

	
015512

	
200701978

3/6/2006

	
8/30/2011

	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
[*]

	
Turkmenistan

	
014366

	
200701979

3/6/2006

	
10/29/2010

	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
[*]

	
Taiwan

	  	
95108512

3/14/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
Ukraine

	  	
200710566/M

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

 

[*] Confidential treatment requested; certain information omitted and filed separately with the SEC.

 

  

  

  

 

	
CO

	
Patent

Number

	
Serial No.

	
Issue

Date

	
Title

	
Estimated Expiration Date

	
US

	
7629488

	
11/368564

3/6/2006

	
12/8/2009

	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
[*]

	
Vietnam

	
9934

	
1-2007-01842

3/6/2006

	
12/20/2011

	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
[*]

	
Vietnam

	
8778

	
1-2007-01841

3/6/2006

	
10/4/2010

	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
[*]

	
PCT

	  	
PCT/US2006/008450

3/6/2006

	  	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
N/A

	
S Africa

	
2007/8810

 

	
2007/8810

3/6/2006

	
1/28/2009

	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
[*]

	
S Africa

	
2007/8809

 

	
2007/8809

3/6/2006

	
3/25/2009

	
PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

	
[*]

 

[*] Confidential treatment requested; certain information omitted and filed separately with the SEC.

 

  

  

  

SCHEDULE 5.2(d)

 

LOCATION OF COLLATERAL

 

3900 Paramount Parkway, Suite 150

Morrisville, NC 27560

300 North Third Street

Wilmington, NC 28401

 

  

 

  

 

SCHEDULE 5.3

 

LITIGATION

 

None.

 

  

 

  

 

SCHEDULE 5.11

 

PRODUCTS AND REQUIRED PERMITS

 

1.  PRODUCTS

a.  PPD-10558

b.  JNJ-32729463

c.  JNJ-27018966

2.  REQUIRED PERMITS

a.  The following regulatory applications for performing human clinical trials:

(i)   PPD10558 - IND No. 76,475

(ii)  JNJ-32729463 - IND No. 102,844 (Tablets), IND No. 107,488 (IV); CTA No. 61-3910-4036748

         (Germany), CTA No. 73/UR/CEBK/01/11 (Poland), Protocol Reference No. EC267853/11 (Chile)

(iii) JNJ-27018966 - IND No. 79,214

 

  

 

  

 

SCHEDULE 6.14

 

POST CLOSING OBLIGATIONS

 

Borrowers shall satisfy and complete each of the following obligations, or provide Agent each of the items listed below, as applicable, on or before the date indicated below, all to the satisfaction of Agent in its sole and absolute discretion:

(a)           By not later than 10 days after the Restatement Date, deliver to Agent an amendment to that certain Landlord’s Waiver and Consent, dated as of August 18, 2011, by and among PPD Development, LP, Furiex Pharmaceuticals, Inc. and Agent in form and substance satisfactory to Agent.

 

Borrower’s failure to complete and satisfy any of the above obligations on or before the date indicated above, or Borrower’s failure to deliver any of the above listed items on or before the date indicated above, shall constitute an immediate an automatic Event of Default.]

 

  

 

  

 

SCHEDULE 7.4

 

INDEBTEDNESS AS OF THE RESTATEMENT DATE

None.

 

  

 

  

 

SCHEDULE 7.7

 

INVESTMENTS AS OF THE RESTATEMENT DATE

See the Collateral Accounts listed on Schedule 5.2(a) hereto.

Furiex Pharmaceuticals, Inc. has the following subsidiaries:

	
  

	
·

	
100% membership interest in APBI Holdings, LLC, a North Carolina limited liability company

	
  

	
·

	
100% membership interest in Development Partners, LLC, a Delaware limited liability company

	
  

	
·

	
500,000 shares of common stock of GenuPro, Inc. a North Carolina corporation representing 100% of its issued and outstanding sharesMSI-EX 10.50

Exhibit 10.50

Motorola Solutions Executive Officer Short Term Incentive Plan
Overview

The Motorola Solutions Executive Officer Short Term Incentive Plan (“STIP”) has been established to: (i) reward and retain Executive Officers of Motorola Solutions, Inc. (“Motorola Solutions” or the “Company”) through competitive rewards, (ii) align individual efforts with the Company’s business goals and (iii) reward Executive Officers for strong individual and business performance.  The Plan is based on calendar-year performance periods commencing January 1, 2013.  The Plan is being implemented pursuant to the terms and conditions of the Omnibus Plan.  Capitalized terms are defined in the “Definitions” section below.   

Eligibility

To be eligible to participate in this Plan, an individual must:

		
	•
	Be a full-time Employee of Motorola Solutions in a capacity as Executive Officer during any portion of a Plan year;

		
	•
	Not be a participant in any other annual or periodic incentive or bonus plan (e.g., sales incentive plans, etc.); and 

		
	•
	Meet one of the following conditions: 

		
	▪
	The Employee is active on a Company payroll as of the end of the Plan Year; 

		
	▪
	The Employee is on a Leave of Absence as of the end of the Plan Year; 

		
	▪
	The Employee Retired from the Company during the Plan Year while actively employed or while on a Leave of Absence;  

		
	▪
	The Employee died during the Plan Year while actively employed by the Company or while on a Leave of Absence 

		
	▪
	The Employee separated from the Company during the Plan Year due to Total and Permanent Disability while actively employed or while on Leave of Absence; or

		
	▪
	The Employee separated from the Company during the Plan Year under certain circumstances in connection with a Change in Control, Divestiture, reduction in force or restructuring, which circumstances are described in the “Administration” section below.

Award Calculation

Awards will be calculated and paid after the close of each Plan Year.  The award amount will be based on the Participant’s Eligible Earnings, Target Award Percentage, and the applicable Business and Individual Performance Factors, as each is defined in the Definitions section, as follows: 

	
									
	Award
	=
	Eligible Earnings
	x
	Target Award Percentage
	x
	Business Performance Factor
	x
	Individual Performance Factor

Target Award Percentages for each Plan Year for Participants shall be determined by the Compensation Committee.  

Business Performance Factors shall be based on financial and/or non-financial factors, as may be determined by the Compensation Committee in its complete discretion.

Individual Performance Factors shall be based on the performance of Participants in contributing to the Company’s business performance.  The Compensation Committee will determine an Individual Performance Factor for each Participant within the range(s) established each Plan Year by the Compensation Committee in its complete discretion.  

Establishing Performance Measures and Goals
Annually, the Compensation Committee will establish the following for the Plan Year no later than the 90th day of the Plan Year:

		
	•
	Performance Measures – the specific financial and/or non-financial measures that will be used to determine the Business Performance Factors for that year, and the relative weighting of each measure.

		
	•
	Payout Scales – the specific performance minimums, targets and maximums for each Performance Measure, and the corresponding payout percentage for each level of business performance for Motorola Solutions and/or any business unit, as appropriate.  

The Compensation Committee will review progress against the performance measures periodically throughout the year.  At the end of the Plan Year, the Compensation Committee will review full year performance and the corresponding management recommendations regarding each Business Performance Factor.  The Compensation Committee, in its discretion, will determine the final Business Performance Factors for the Company and/or any business unit, as appropriate.

Payout Process 

		
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	All earned awards will be paid in cash.  Payment will be made as soon as administratively practical during the calendar year immediately following the close of a Plan Year (unless a Participant makes an irrevocable election under any deferred compensation arrangement subject to Section 409A of the Internal Revenue Code of 1986, as amended, to defer payment of all or a portion of the Participant’s award, in which case such payment, if any, shall be made in accordance with such election).

		
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	A Participant shall have no right to an award until that award is paid. 

General Provisions

		
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	Awards are subject to all applicable withholding taxes and other required deductions.

		
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	The Plan will not be available to Employees who are subject to the laws of any jurisdiction which prohibits any provisions of this Plan or in which tax or other business considerations make participation impracticable in the judgment of the  Compensation Committee.

		
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	This Plan does not constitute a guarantee of employment nor does it restrict the Company’s rights to terminate employment at any time or for any reason.

		
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	The Plan and any individual award is offered as a gratuitous award at the sole discretion of the Company.  The Plan does not create vested rights of any nature nor does it constitute a contract of employment or a contract of any other kind.  The Plan does not create any customary concession or privilege to which there is any entitlement from year-to-year, except to the extent required under applicable law.  Nothing in the Plan entitles an Employee to any remuneration or benefits not set forth in the Plan nor does it restrict the Company’s rights to increase or decrease the compensation of any Employee, except as otherwise required under applicable law.

		
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	Except as explicitly provided by law, the awards shall not become a part of any employment condition, regular salary, remuneration package, contract or agreement, but shall remain gratuitous in all respects.  Awards are not to be taken into account for determining overtime pay, severance pay, termination pay, pay in lieu of notice or any other form of pay or compensation.

		
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	Except as explicitly provided by law, this Plan is provided at the Company’s sole discretion and the Compensation Committee may modify or terminate it at any time, prospectively or retroactively, without notice or obligation for any reason.  In addition, there is no obligation to extend the Plan or establish a replacement plan in subsequent years.

		
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	All awards to Participants who are subject to the terms and conditions of the Recoupment Policy, as it may be amended from time to time, including as it may be amended to comply with Section 10D of the Exchange Act (the “Recoupment Policy”), shall be subject to the terms of the Recoupment Policy.  The Recoupment Policy provides that, in the event of certain accounting restatements (a “Policy Restatement”), the Company’s independent directors may require, among other things, reimbursement of all or a portion of the gross amount of any bonus or incentive compensation paid to such Participants hereunder on or after January 1, 2008, if and to the extent the conditions set forth in the Recoupment Policy apply.  Any determinations made by the independent directors in accordance with the Recoupment Policy shall be binding upon such Participant.  The Recoupment Policy is in addition to any other remedies which may be otherwise available to the Company at law, in equity or under contract, or otherwise required by law, including under Section 10D of the Exchange Act.

		
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	The Plan shall not be funded in any way.  The Company shall not be required to establish any special or separate fund or to make any other segregation of assets to assure the payment of awards.  To the extent any person acquires a right to receive payment under the Plan, such right will be no greater than the right of an unsecured general creditor of the Company. 

		
	•
	Award opportunities may not be sold, transferred, pledged, assigned or otherwise alienated or hypothecated, other than by will or by the laws of descent and distribution.

Administration 

		
	•
	The Compensation Committee has the overall responsibility for administering and amending this Plan, subject to the following: 

		
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	The Compensation Committee will approve at the close of the Plan Year the final Business Performance Factors and the aggregate dollar payout amount, following a review of the underlying calculations, including any recommended adjustments to the performance measures made during the course of, or with respect to, the Plan Year.

		
	•
	The Compensation Committee, in its discretion, can for good reason modify the Business Performance Factors and can include or exclude individual items from the calculation of the Business Performance Factors.

		
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	The Compensation Committee may delegate ministerial duties under the Plan to such of the Company’s officers as it so determines.  . 

		
	•
	Any claims for payment under the Plan or any other matter relating to the Plan must be presented in writing to the Compensation Committee within 60 days after the event that is the subject of the claim.  The Compensation Committee will then provide a response within 60 days of receiving the claim (or within 120 days if special circumstances require an extension of time and written notice was provided to the Employee before the expiration of the initial 60 day period), which shall be final and binding.

		
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	Because retention is an important objective of this Plan and awards do not bear a precise relationship to time worked within the Plan Year or length of service with the Company, the following will apply to Participants who separate from employment (payroll) prior to the end of the Plan Year.  All pro rata awards outlined below shall be based on the Participant’s Eligible Earnings for time actively worked in the Plan Year, their applicable Target Award Percentage and the applicable Business Performance Factor approved by the Compensation Committee after the Plan Year.  Pro rata payouts will be made at the same time as payouts are issued to all other Plan participants.

		
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	If the reason for separation is Total and Permanent Disability, death or Retirement, whether or not the Participant is then on a Leave of Absence, the Participant shall be eligible for a pro rata award.  Any such award payable on behalf of a deceased Participant shall be paid to the decedent’s estate.  

		
	•
	If the reason for separation is due to a Divestiture, then the Compensation Committee, in its discretion, shall determine if the Participant is eligible for an award, if any. 

		
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	If the reason for Separation is Serious Misconduct, such Employee shall not receive any award under this Plan.

		
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	If the reason for separation is in connection with a Change in Control, the applicable Change in Control Severance Plan(s) (or in the case of the CEO, the applicable employment agreement) shall determine the Participant’s entitlement to an award, if any, for the Plan Year in which the Participant is terminated or for any prior Plan Year.

		
	•
	For any other Participant who separates from employment prior to the end of the Plan Year, such Employee shall not receive any award under this Plan.

		
	•
	A Participant on any type of Leave of Absence shall not be considered to be actively working during the Leave of Absence for purposes of this Plan.

		
	•
	Awards for transferred, promoted or demoted Participants will be calculated using (i) the Individual Performance Factor assigned at the end of the Plan Year and (ii) the Target Award Percentages and Business Performance Factors prorated for the portions of the Plan Year the Participant was assigned different Target Award Percentages or was in different business units during the Plan Year.

Definitions

Business Performance Factors: the business performance measures used to calculate an award under this Plan.  

Change in Control Severance Plan: includes, but is not limited to, the Motorola Solutions, Inc. 2011 Senior Officer Change in Control Plan, the Motorola Solutions, Inc. Legacy Senior Officer Amended and Restated Change in Control Plan, the Motorola Solutions, Inc. Legacy Corporate Officer Amended and Restated Change in Control Plan and the Motorola Solutions, Inc. Legacy Corporate Officer Transition Amended and Restated Change in Control Plan.

Company: Motorola Solutions, Inc. and its subsidiaries.  

Compensation Committee: the Compensation and Leadership Committee of the Motorola Solutions, Inc. Board of Directors.

Divestiture: the sale, lease, outsourcing arrangement, spin off or similar transaction wherein a subsidiary is sold or whose shares are distributed to the Motorola Solutions stockholders, or any other type of asset transfer or transfer of any portion of a facility or any portion of a discrete organizational unit of the Company or a subsidiary.

Eligible Earnings: the base salary earned during the Plan Year.  

Employee: a person in an employee-employer relationship with the Company whose base wage or base salary is processed for payment by the payroll department(s) of the Company or a subsidiary, and not by any other department of the Company.  The term Employee shall exclude the following: 

		
	•
	Any independent contractor, consultant or individual performing services for the Company who has entered into an independent contractor or consultant agreement; 

		
	•
	Any individual performing services under an independent contractor or consultant agreement, a purchase order, a supplier agreement or any other agreement that the Company enters into for services; 

		
	•
	Any person classified by the Company as a temporary or contract labor (such as black badges, brown badges, contractors, contract employees, job shoppers) regardless of the length of service; and

		
	•
	Any “leased employee” as defined in Section 414(n) of the U.S. Internal Revenue Code of 1986, as amended.

Such individuals shall be precluded from retroactive participation in the Plan, even if a court or governmental or regulatory entity subsequently reclassifies such individuals as common law employees of the Company on a retroactive basis.  

Executive Officer(s): officers (as such term is defined in Rule 16a-1(f) under the Securities Exchange Act of 1934, as amended) of the Company.

Individual Performance Factor: the individual Participant performance measures used to calculate an award under this Plan. 

Leave of Absence: an approved leave of absence.  
Omnibus Plan: the Motorola Solutions Omnibus Incentive Plan of 2006, as Amended and Restated November 9, 2011, or any subsequent amendment and restatement, or any successor plan.
Participant: an Employee who meets the eligibility requirements set forth above.
Plan: the Motorola Solutions Executive Officer Short Term Incentive Plan, as amended from time to time.
Plan Year: calendar-year performance periods commencing each January 1 and ending the subsequent December 31.
Retired or Retirement: this Plan utilizes the definition of “retiree” and “retirement” that appear in the primary retirement plan covering the Participant.
Section 16: Section 16 of the Securities Exchange Act of 1934, as amended.
Section 162(m): Section 162(m) of the Internal Revenue Code, as amended.
Serious Misconduct: any misconduct identified as a ground for termination in the Motorola Solutions Code of Business Conduct, or the human resources policies or other written policies or procedures.
Target Award Percentages: target award percentages applicable to each Participant and used to calculate an award under this Plan, as determined by the Compensation Committee.
Total and Permanent Disability: for (i) U.S. employees, entitlement to long-term disability benefits under the Motorola Solutions Disability Income Plan, as amended and any successor plan or a determination of a permanent and total disability under a state workers compensation statute and (ii) non-U.S. employees, as established by applicable Motorola Solutions policy or as required by local regulations.
If a term is used but not defined in the Plan, it has the meaning given such term in the Omnibus Plan.

Applicable Law

To the extent not preempted by federal law, or otherwise provided by local law, the Plan will be construed in accordance with, and governed by, the laws of the state of Illinois without regard to any state’s conflicts of laws principles.  Any legal action related to this Plan shall be brought only in a federal or state court located in Illinois.  
 

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