Document:

Exhibit 10.39

 

		Ground Lease Agreement	 

 

 

UENO FINE CHEMICALS INDUSTRY LTD. (hereinafter, “Party
A”), and R-Tech Ueno, Ltd. (hereinafter, “Party B”) form the following agreement regarding the ground lease of
the land owned by Party A which is described at the end of the document (hereinafter, “This Land”).

 

Article 1 (Purpose of Use)

Party A agrees to lease This Land in order
for Party B to have ownership of a building.

 

Article 2 (Lease term)

		1.	The lease period for This Land is 30 years from April 1, 2001.

		2.	If attempting to end this agreement after fulfilling the above-stated period, Party A or Party B must inform the other in writing
by 3 months prior.

		3.	After fulfillment of the contract period, this contract can be extended for 20 years by agreement between Party A and Party
B. Following fulfillment of that period, the contract can be extended by 10 years.

 

Article 3 (Cancellation during the contract period)

If attempting to cancel this contract, Party
A or Party B must inform the other in writing 3 months prior and cancellation must be based on consent between Party A and
Party B.

 

Article 4 (Security deposit)

		1.	Party B shall pay a security deposit to Party A of an amount [...***...] of [...***...] by the first day
of the leasing period.

		2.	If the rent increases or decreases, the security deposit will increase or decrease accordingly with the difference settled
within 1 month from the date of rent increase/decrease.

		3.	Party B [...***...] the [...***...] to [...***...] Party A.

		4.	If based on this contract debts owed by Party B [...***...], Party A [...***...] the [...***...]
for this [...***...]. After receiving a notice of [...***...], [...***...] must [...***...]
the [...***...].

		5.	No [...***...] is [...***...] to the [...***...].

		6.	After ending or cancelling this contract, and after Party B has left This Land in its original condition as well as fulfilling
repayment of all debts owed to Party A, the remainder of the security deposit stipulated in Item 1 shall be returned to Party B.

 

Article 5 (Rent)

The rent for 1 month shall be a sum of 401,000
yen, with the following month’s portion paid by Party B to Party A by the end of every month. When the above-stated rent
has been deemed inequivalent to the circumstances based on fluctuations in commodities, increases in land tax, public charges and
other administrative costs, rent fluctuations in adjacent areas, and other economic factors, it can be modified by Party A and
Party B.

 

Article 6 (Delinquency charges)

If Party B falls into delinquency regarding
payment of rental fees, delinquency charges of [...***...] shall be applied each day from the day of delinquency.

 

Confidential
and Proprietary 

CONFIDENTIAL
TREATMENT HAS BEEN REQUESTED FOR PORTIONS OF THIS EXHIBIT. THE COPY FILED HEREWITH OMITS THE INFORMATION SUBJECT TO A CONFIDENTIALITY
REQUEST. OMISSIONS ARE DESIGNATED [***]. A COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND
EXCHANGE COMMISSION.

    

     

    

Article 7 (Tax and public charges)

The fixed property tax, land holding tax,
and other taxes for This Land will be borne by Party A.

 

Article 8 (Contract termination)

If circumstances arise such that any of
the following items (1), (2), (4), or (5) become applicable to Party B, Party A can terminate the contract without prior notice.
Also, should circumstances arise such that item (3) becomes applicable to Party B, Party A will demand of Party B resolution of
the applicable situation within 30 days, and can terminate this contract if the applicable situation has still not been resolved
after that period. For all cases, if Party A incurs any damages, a demand can be made of Party B for compensation of those damages.

		(1)	Delinquency in payment beyond 2 months for the rent and other debts.

		(2)	If the leased property is used for purposes other than stated in Article 1.

		(3)	Violation of this contract or any of the items in appended agreements.

		(4)	When provisional seizure, provisional injunction, compulsory execution, bankruptcy, civil rehabilitation, corporate restructuring,
corporate renewal, liquidation, special liquidation, or dissolution proceedings have begun.

		(5)	When trust has been damaged considerably.

 

Article 9 (Gratuitous return)

In the future, when this contract is cancelled
or ends due to term fulfillment, Party B will not invoice Party A for evacuation fees, business guarantees, or any other items
whatsoever.

 

Article 10 (Items not stipulated)

When necessary, Party A and Party B shall
cooperate in good faith to resolve issues surrounding items not provided for by this contract and items where doubt has arisen
regarding interpretation.

 

IN WITNESS WHEREOF, Party A and Party B
hereto have executed this agreement in duplicate by placing their respective signatures and seals thereon, and each party shall
keep one original.

 

March 16, 2001

 

	 	Party A
	 	2-4-8 Koraibashi, Chuo-ku, Osaka-shi
	 	UENO FINE CHEMICALS INDUSTRY LTD.
	 	[...***...] [seal] [seal]
	 	 
	 	Party B
	 	4-1 Techno-park, Sanda-shi, Hyogo-ken
	 	R-Tech Ueno Ltd.  
	 	[...***...] [seal] [seal]

 

 

 

 

 

 

Confidential
and Proprietary 

CONFIDENTIAL
TREATMENT HAS BEEN REQUESTED FOR PORTIONS OF THIS EXHIBIT. THE COPY FILED HEREWITH OMITS THE INFORMATION SUBJECT TO A CONFIDENTIALITY
REQUEST. OMISSIONS ARE DESIGNATED [***]. A COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND
EXCHANGE COMMISSION.

    

     

    

Diagram of land for lease

 

The land which Party A rents to Party B, and Party B rents from
Party A is as follows.

 

4-1 Techno-park, Sanda-shi, Hyogo-ken

Pharmaceutical product bulk factory Plot [...***...]
m2

 

[...***...].

 

END

 

 

 

 

 

 

Confidential
and Proprietary 

CONFIDENTIAL
TREATMENT HAS BEEN REQUESTED FOR PORTIONS OF THIS EXHIBIT. THE COPY FILED HEREWITH OMITS THE INFORMATION SUBJECT TO A CONFIDENTIALITY
REQUEST. OMISSIONS ARE DESIGNATED [***]. A COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND
EXCHANGE COMMISSION.

    

     

    

R-Tech Ueno [illegible] [seal]

 

UENO FINE CHEMICALS INDUSTRY LTD Sanda branch

 

[MAP OF LEASED PREMISES]

[...***...]

 

 

 

 

 

 

 

 

Confidential
and Proprietary 

CONFIDENTIAL
TREATMENT HAS BEEN REQUESTED FOR PORTIONS OF THIS EXHIBIT. THE COPY FILED HEREWITH OMITS THE INFORMATION SUBJECT TO A CONFIDENTIALITY
REQUEST. OMISSIONS ARE DESIGNATED [***]. A COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND
EXCHANGE COMMISSION.Exhibit 10.40

 

Summary of New Technology Development Consignment Agreement between
R-Tech Ueno and the Japan Agency for Medical Research and Development, dated April 1, 2015

 

Under this Agreement, the Japan Agency for Medical Research and
Development (“AMED”) agreed to lend R-Tech Ueno Ltd. (“R-Tech”) costs for the development
of unoprostone 0.15% eye drops (“unoprostone”) for the treatment of retinitis pigmentosa (the “Development”).
As of December 31, 2015, the outstanding loan amount stands at JPY ¥1,049,000,000 or approximately USD $9,218,328.

 

If the Development is deemed to be successful, then R-Tech will
repay the outstanding loan amount in ten equal annual instalments following such determination. In addition, in the event that
the Development results in a new marketing authorization for unoprostone, R-Tech will pay AMED a small, single-digit royalty on
net sales of the unoprostone for such indication for a period of ten years following first commercial sale.

 

If the Development is deemed to be a failure, R-Tech will repay
10% of the costs in a lump sum payment and will be released from the repayment obligations of the remaining 90%.

 

The term of the Agreement is effective until i) the Development
is deemed successful and the parties enter into a license agreement; or ii) the Development is deemed to be a failure, triggering
the repayment described above.

 

AMED may terminate the Agreement i) if R-Tech engages in an unjust
or unfair act in regard to the implementation of the Agreement; ii) If R-Tech breaches any of the provisions of the Agreement;
iii) if any researcher of R-Tech engages in an unjust act or inappropriate accounts processing; iv) if R-Tech breaches any of the
provision of any guidelines relating to public research stipends; v) if R-Tech breaches any representation and warranty regarding
anti-social forces (e.g., organized crime syndicates, cartels, gangs, etc.); vi) if R-Tech files or is filed for insolvency
proceedings; vii) if R-Tech is subject to suspension of banking transactions; or vii) if R-Tech becomes the subject of seizure
or provisional disposition.Exhibit 10.41

 

 

Basic Transaction Agreement Concerning
Outsourced Manufacturing

 

 

 

 

 

 

 

 

 

 

 

R-Tech Ueno, Ltd.

 

 

Nissan Chemical Industries, Ltd.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Confidential and Proprietary 

 

CONFIDENTIAL TREATMENT
HAS BEEN REQUESTED FOR PORTIONS OF THIS EXHIBIT. THE COPY FILED HEREWITH OMITS THE INFORMATION SUBJECT TO A CONFIDENTIALITY REQUEST.
OMISSIONS ARE DESIGNATED [***]. A COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE
COMMISSION.

     

     

    

Basic Transaction Agreement Concerning Outsourced Manufacturing

 

 

 

R-Tech Ueno, Ltd. (hereinafter “R-Tech”) and Nissan
Chemical Industries, Ltd. (hereinafter “Nissan Chemical”) hereby enter into the following agreement to signify that
they have agreed as follows in regard to the outsourced manufacturing and supply of [...***...], which is the synthetic
raw material of RU-0211 developed as a new pharmaceutical by R-Tech.

 

Article 1 (Definitions)

 

The meaning of the following terms in this agreement shall be as
defined as follows.

 

		1)	“Product” refers to [...***...].

 

		2)	“Work” refers only to the outsourcing of the manufacture of the “Product”
by R-Tech to Nissan Chemical, and the undertaking of Nissan Chemical to supply this to R-Tech, in accordance with the agreement
(hereinafter referred to as “Manufacturing Technology Transfer Agreement”) related to technical transfer entered into
by R-Tech and Nissan Chemical dated November 15th 2001, and based on the technical, economic, and corporate investigations
carried out jointly by R-Tech and Nissan Chemical, and following the stipulations of the Agreement.

 

		3)	“Confidential Information” refers to all information, after the conclusion of the Non-Disclosure
Agreement concerning Investigations into Outsourced Manufacture of New Drug Intermediates entered into by R-Tech and Nissan Chemical
dated June 13th 2000 (hereinafter “Non-Disclosure Agreement”) or the conclusion of the Manufacturing Technology
Transfer Agreement, physico-chemical qualities, synthetic method, and other information, electronic files and data, etc. related
to the Product and related compounds, including RU-0211, already disclosed, quality standards and packaging standards related to
the Product determined after the conclusion of the Agreement (hereinafter referred to generally as quality/standards), and work-related
secrets, technology, information, knowledge, design, technical knowhow, industrial property rights, and other intellectual property
rights related to the Product and related compounds disclosed as necessary by R-Tech to Nissan Chemical in accordance with the
performance and progress of this work. Further, Confidential Information includes information on the manufacturing facilities of
Nissan Chemical, technology, information, knowledge, design, technical knowhow, industrial property rights, other intellectual
property rights, and business secretes disclosed by Nissan Chemical to R-Tech or learned by R-Tech as a necessary part of carrying
out this work. However, this excludes the following.

 

	Information that was already public knowledge at the point it was
disclosed by the disclosing party, or information that became public knowledge for no reason attributable to the disclosed party
after being disclosed by the disclosing party
	Information that was already possessed by the disclosed party at
the point that it was disclosed by the disclosing party, and information for which it can be proven with legitimate evidence or
means that it was not obtained either directly or indirectly from the disclosing party.
	Information obtained by the disclosed party from a third party
without restriction, and information for which it can be proven with legitimate evidence or means that the third party did not
obtain it either directly or indirectly from the disclosing party.
	Information for which it can be proven with legitimate evidence
or means that the disclosed party independently obtained the information without receiving the disclosure of confidential information
from the disclosing party

 

1

 

Confidential and Proprietary 

 

CONFIDENTIAL TREATMENT
HAS BEEN REQUESTED FOR PORTIONS OF THIS EXHIBIT. THE COPY FILED HEREWITH OMITS THE INFORMATION SUBJECT TO A CONFIDENTIALITY REQUEST.
OMISSIONS ARE DESIGNATED [***]. A COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE
COMMISSION.

     

     

    

 

Article 2 (Ordering)

 

Nissan Chemical shall manufacture the Product conforming to the
quality/standards only for the purpose of supplying it to R-Tech in accordance with orders and directions from R-Tech, and deliver
this by the deadline.

 

 

Article 3 (Quality/standards)

 

Quality/standards shall be determined separately in writing, and
the quality/standards may be changed or improved as needed based on written negotiations after separate discussion between R-Tech
and Nissan Chemical.

 

 

Article 4 (Transaction Conditions)

 

The price for transferring this Product to the location (Sanda Techno
Park, Hyogo) specified by R-Tech shall be as determined in attachment 1 attached to the Agreement. R-Tech and Nissan Chemical shall,
each year, hold a meeting on the final day of the R-Tech business year (April 1st to March 31st the following
year) and negotiate in writing the transaction conditions for the following year, such as the price and delivery method for the
Product. If R-Tech or Nissan Chemical recognize that there is a significant difference between the annual purchase plan and the
actual purchase quantity for that year at the time the transaction conditions for the said year are determined, they may request
a consultation with the other party regarding a revision to the transaction conditions for the said year.

 

2. The ownership rights for the Product and burden of risk related
to loss or damage shall transfer from Nissan Chemical to R-Tech at the point of transfer to the specified location as described
in the previous paragraph.

 

 

Article 5 (Purchase Plan and Deadline)

 

R-tech shall notify Nissan Chemical of the annual product purchase
plan and deadline for the following year in writing by [...***...] before the last day of the R-Tech business year. If
there is a change fo the annual product purchase plan, R-Tech shall, as a general rule, notify Nissan Chemical in writing [...***...]
before the change. R-Tech shall issue a purchase order clarifying the quantity of Product and deadline at least one month before
the scheduled deadline, in accordance with the annual product purchase plan.

 

 

Article 6 (Manufacture and Delivered Product)

 

Nissan Chemical, on receiving the purchase order for the Product
in writing from R-Tech, shall confirm this immediately in writing and deliver the Product which can be proven to conform to the
quality/standards (test results table attached) to R-Tech by the specified deadline. R-Tech, in accordance with the quality/standards,
shall test the delivered Product within [...***...] business days of receiving the Product, and notify Nissan Chemical
of the test results. R-Tech may refuse and return to Nissan Chemical any Product that does not conform to the quality/standards.

 

If Nissan Chemical, during the process of manufacturing this Product,
learns of the occurrence of any irregularity that may affect the quality/standards, they shall promptly notify R-Tech in writing,
and this shall be resolved by discussion between R-Tech and Nissan Chemical.

 

 

Article 7 (Payment Conditions)

 

When Nissan Chemical has delivered the Product to R-Tech, R-Tech
shall settle payment by bank transfer for the amount up to the last day of each month by the last day of the following month for
the Product inspected and accepted by R-Tech.

 

 

2

 

Confidential and Proprietary 

 

CONFIDENTIAL TREATMENT
HAS BEEN REQUESTED FOR PORTIONS OF THIS EXHIBIT. THE COPY FILED HEREWITH OMITS THE INFORMATION SUBJECT TO A CONFIDENTIALITY REQUEST.
OMISSIONS ARE DESIGNATED [***]. A COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE
COMMISSION.

     

     

    

Article 8 (Acquisition of Licensing)

 

Nissan Chemical shall legally obtain the necessary licenses in relation
to the outsourced manufacture of this Product from the competent authorities. R-Tech shall provide technical support to Nissan
Chemical during the process of application for such licenses.

 

 

Article 9 (Manufacturing Method, Manufacturing Management Method,
Reversion of Rights)

 

Nissan Chemical shall manufacture this Product in accordance with
the manufacturing method and manufacturing management method agreed through discussion between R-Tech and Nissan Chemical. Further,
they shall follow cGMP in order to guarantee its quality as a pharmaceutical raw material.

 

All technical achievements, such as inventions, designs, utilities,
knowhow, etc. regarding manufacturing technology for the Product obtained through not only performance of the Manufacturing Technology
Transfer Agreement but also this Agreement shall be shared between R-Tech and Nissan Chemical. However, the rights for the manufacturing
technology itself disclosed by R-Tech to Nissan Chemical, based on the stipulations of the Manufacturing Technology Transfer Agreement
and this Agreement, shall remain with R-Tech.

 

2. R-Tech, based on the achievements shared as stipulated in the
previous paragraph, may use these free of charge on the condition that they obtain the consent of Nissan Chemical. However, Nissan
Chemical may not unreasonably refuse the said consent. After this Agreement is terminated, Nissan Chemical shall consent in advance
that R-Tech may use the achievements shared as stipulated in the previous paragraph freely without charge. As long as Nissan Chemical
does not breach their duties under the other stipulations of this Agreement, the Manufacturing Technology Transfer Agreement, or
the Non-Disclosure Agreement, Nissan Chemical may use the above shared technology, on condition of R-Tech’s consent, in relation
to R-Tech freely without charge. However, R-Tech may not unreasonably refuse the said consent.

 

 

Article 10 (Product Liability)

 

If R-Tech or a third party suffer physical or property damage due
to the Product, this shall be resolved quickly through mutual close contact between R-Tech and Nissan Chemical.

 

If, among the physical and property damage related to products manufactured
and marketed using the Product, it is believed that the said damage is caused by this Product, R-Tech and Nissan Chemical shall
cooperate with each other immeditately to investigate the cause in order to resolve the claim. If after analyzing the cause, it
becomes clear that the damage has occurred as a result of the Product delivered by Nissan Chemical, Nissan Chemical shall take
responsibility for this. However, if the said damage is a result of following the manufacturing method or manufacturing management
method agreed between R-Tech and Nissan Chemical as stipulated in article 9, this shall be the responsibility of R-Tech.

 

2. If the damage in the previous paragraph occurs due to foreign
bodies or impurities admixed into the Product that are unpredictable or unforeseen based on the quality/standards, this shall be
discussed between R-Tech and Nissan Chemical. However, this discussion shall not impact the responsibility described in the previous
paragraph.

 

 

Article 11 (Maintence of Confidentiality)

 

R-Tech and Nissan Chemical shall not disclose or leak confidential
information disclosed by the other party and shall handle this information confidentially, and not use or utilize it for any other
objective other than performing this work.

 

R-Tech or Nissan Chemical, upon receiving disclosure of confidential
information from the other party, shall record the title or inventory in the case of written form, or if disclosed verbally, the
disclosing party shall submit the content of the said confidential information to the other party within [...***...]
of the said disclosure to the other party.

 

3

 

Confidential and Proprietary 

 

CONFIDENTIAL TREATMENT
HAS BEEN REQUESTED FOR PORTIONS OF THIS EXHIBIT. THE COPY FILED HEREWITH OMITS THE INFORMATION SUBJECT TO A CONFIDENTIALITY REQUEST.
OMISSIONS ARE DESIGNATED [***]. A COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE
COMMISSION.

     

     

    

2. R-Tech and Nissan Chemical shall limit those people connected
to and handling the confidential information disclosed by the other party to those executives or employees reasonably considered
necessary for the objective of performing this work, and shall bear responsibility for the non-disclosure by these people as well.
Further, they shall bear the same responsibility in regard to retirees.

 

 

Article 12 (Restrictions on Manufacture and Sales)

 

Nissan Chemical shall not manufacture, supply, or sell this Product,
the intermediates for this Product, or RU-0211 to any third party other than R-Tech, for any purpose whatsoever.

 

 

Article 13 (Force Majeure)

 

If due to a regulation or order from the government, an emergency
situation, act of God, strike, other circumstances exceeding the reasonable authority of the other party, or reasonably unexpected
situation (“Force Majeure Circumstance”), it becomes significantly difficult or impossible for the party in question
to perform their duties under the Agreement, the party in question shall not bear any responsibility to the other party for the
non-performance of the said duties. However, the party in question shall promptly submit notice of the occurrence of the Force
Majeure Circumstance in writing. If the Force Majeure circumstance continues for six months or more, it shall be discussed and
handled in good faith between R-Tech and Nissan Chemical.

 

 

Article 14 (Term)

 

The valid term of this Agreement shall be from March 22nd
2004 to March 21st 2012.

 

Following this, unless there is a declaration in writing by either
of the parties to the other party giving Three months advance notice, the agreement shall be extended for one year, and thereafter
the same. However, when five years have passed since the date of the Agreement, R-Tech shall reserve the right to cancel the Agreement
by providing one-year advance notice.

 

Further, when five years have passed since the date of the Agreement,
and economic circumstances unforeseen when entering into this Agreement occur and persist, and it is reasonably judged based on
this that it is significantly dificult to continue this Agreement, Nissan Chemical shall reserve the right to cancel this Agreement
by providing one-year notice to R-Tech. However, Nissan Chemical, in addition to providing necessary cooperation such as introducing
new suppliers for raw materials, shall continue to provide the Product at the price in effect when cancellation is declared until
a new supply structure for the Product is established, and R-Tech shall make every effort to promptly establish the new supply
structure for the Product.

 

All agreements and promises, regardless of the means, such as documents,
word-of-mouth, or electronic information exchange, made before entering into this Agreement, excluding the Non-Disclosure Agreement
and Manufacturing Technology Transfer Agreement, shall be absorbed within this Agreement, and no agreement other than this one
shall exist.

 

 

Article 15 (Breaches of Agreement etc.)

 

If either R-Tech or Nissan Chemical commit a breach of this Agreement,
and despite the said breach being identified by the other party, it is not corrected within a reasonable period, the other party
may cancel the agreement by providing six months’ notice in writing, and the party committing the breach of the agreement
shall be responsible for compensating any damages occurring based on the said breach.

 

 

4

 

Confidential and Proprietary 

 

CONFIDENTIAL TREATMENT
HAS BEEN REQUESTED FOR PORTIONS OF THIS EXHIBIT. THE COPY FILED HEREWITH OMITS THE INFORMATION SUBJECT TO A CONFIDENTIALITY REQUEST.
OMISSIONS ARE DESIGNATED [***]. A COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE
COMMISSION.

     

     

    

 

2. If any of the following apply to R-Tech or Nissan Chemical, the
other party may immediately terminate all or part of this Agreement without providing any notification.

 

		1	If an order for revocation or cessation of business related to this Product is received from the
supervisory authorities.

 

		2	If an application is made or received for corporate reorganization, corporate rehabilitation, bankruptcy,
or special liquidation, or an order halting bank transactions is received

 

 

Article 16 (Maintenance of Confidentiality after Termination of
the Agreement)

 

In accordance with the stipulations of article 14 and article 15,
even when this Agreement is terminated, stipulations in the Agreement shall retain their efficacy after the termination of the
Agreement, and the duty of non-disclosure stipulated in article 11 shall survive effectively for [...***...] after the
termination of the Agreement.

 

 

Article 17 (Assignment)

 

R-Tech and Nissan Chemical shall not, without the prior written
permission of the other party, assign, transfer, or use as security their rights and duties as determined in this Agreement to
a third party.

 

 

Article 18 (Items for Discussion)

 

If circumstances not covered in this Agreement occur or if there
are doubts regarding the intepretation of the clauses, R-Tech and Nissan Chemical shall resolve this in good faith and in a friendly
fashion.

 

In witness of its establishment, this Agreement shall be created
in duplicate and R-Tech and Nissan Chemical shall each store one copy after signing and affixing their seal thereto.

 

 

 

May 22nd 2004

 

	R-Tech:	 	4-1 Techno Park, Sanda-shi, Hyogo 

R-Tech Ueno, Ltd. 

President: MitsunagaTada	 		 		 
	 	 	 	 	[Seal] R-Tech Ueno,
    Ltd.	 	[Seal] R-Tech Ueno,
    Ltd.	 
	 	 	 	 	 	 	 	 
	Nissan Chemical:	 	3-7-1 Kanda Nishikicho, Chiyoda-Ku, Tokyo
 Nissan Chemical Industries, Ltd. 
 Executive Director Chemical Business General Manager: Koichiro Yanagida	 	 	 
	 	 	 	 	 	 	 	 
	 	 	 	 		 		 
	 	 	 	 	[Seal] Nissan
    Chemical Industries, Ltd.	 	[Seal] Nissan
    Chemical Industries, Ltd.	 

 

 

5

 

Confidential and Proprietary 

 

CONFIDENTIAL TREATMENT
HAS BEEN REQUESTED FOR PORTIONS OF THIS EXHIBIT. THE COPY FILED HEREWITH OMITS THE INFORMATION SUBJECT TO A CONFIDENTIALITY REQUEST.
OMISSIONS ARE DESIGNATED [***]. A COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE
COMMISSION.

     

     

    

 

Attachment: Attached document 1

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

6

 

Confidential and Proprietary 

 

CONFIDENTIAL TREATMENT
HAS BEEN REQUESTED FOR PORTIONS OF THIS EXHIBIT. THE COPY FILED HEREWITH OMITS THE INFORMATION SUBJECT TO A CONFIDENTIALITY REQUEST.
OMISSIONS ARE DESIGNATED [***]. A COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE
COMMISSION.

     

     

    

 Attachment 1

 

 

 

The price determined in Article 4 of the Agreement is as follows:

 

 

 

		1.	Process validation first lot

 

(manufacturing scale [...***...] g, purchase
unit [...***...] g)

 

[...***...] yen/g

 

 

		2.	From the process validation second lot onward, the price and unit price shall be calculated according
to the following formula based on the [...***...]. If the [...***...], this will be discussed separately.

 

 

Price= [...***...]

 

Unit price for the said year=[...***...]

 

 

 

If [...***...] kg is purchased [...***...],
the calculation example applying the previous conditions is as follows.

 

[...***...]

 

[...***...]

 

[...***...]

 

[...***...]

 

 

 

However, if process rationalization/efficiency or changes in other
transaction conditions etc. occur due to a combination of changes to the manufacturing conditions, changes to specifications, or
manufacturing results, the above formula shall be revised in consideration of the content of the said changes.

 

End

 

 

 

 

 

 

 

7

 

Confidential and Proprietary 

 

CONFIDENTIAL TREATMENT
HAS BEEN REQUESTED FOR PORTIONS OF THIS EXHIBIT. THE COPY FILED HEREWITH OMITS THE INFORMATION SUBJECT TO A CONFIDENTIALITY REQUEST.
OMISSIONS ARE DESIGNATED [***]. A COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE
COMMISSION.

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