Document:

Exhibit 10.01 

THIS AMENDMENT AGREEMENT is made the       day
    of November, 2005

BETWEEN:

	
      1.      		
      SHIRE EXECUTIVE SERVICES INC.,
      a Delaware corporation having its registered offices at 1209 Orange Street,
    Wilmington, Delaware (the “Company”); and	
	 
	
      2.      		
      MATTHEW EMMENS of
      Hampshire International Business Park, Chineham, Basingstoke, Hampshire,
    RG24 8EP (the “Director”).	

WHEREAS:

	
(A)      		
Shire Pharmaceuticals Group plc is proposing to enter into the Scheme of Arrangement (as defined below);	
	 
	
(B)      		
In connection with the Scheme of Arrangement becoming effective, both the Company and the Director wish to amend the Contract (as defined below) such that it shall apply to the Director’s service as Chief Executive
Officer of Shire plc rather than his service as Chief Executive Officer of Shire Pharmaceuticals Group plc;	
	 
	
(C)      		
In addition, both the Company and the Director wish to amend the Contract to provide that the reimbursement of non-commercial flight expenses shall be, when the Director flies his own airplane, for the cost of airplane fuel
actually incurred by him; and	
	 
	
(D)      		
In consideration of the agreements of the Company made herein and other good and valuable consideration, receipt of which is hereby acknowledged, each of the Company and the Director desires to enter into this
agreement.	

NOW IT IS AGREED as follows:

	
1.      		
INTERPRETATION	
	 
	
1.1      		
In this agreement (including in its recitals):	
	 

	 	“Contract”	 	 means the amended and restated
        employment agreement relating to the employment of the Director as Chairman
        of the Board of Directors and Chief Executive of the Company, Chief Executive
        Officer of Shire Pharmaceuticals Group plc and Chairman of the Board
        of Directors of Shire US Inc., made between the Company and the Director
    and dated 12th March 2004;
	 	 	 	 
	 	“Effective
    Date”	 	 means the date upon which
        the Scheme of Arrangement becomes effective in accordance with its terms;
    and

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	 	“Scheme of Arrangement”	 	means
        the proposed scheme of arrangement under  section
        425 of the Companies Act 1985 whereby Shire will be interposed as the
        new holding company of Shire Pharmaceuticals Group plc, in its present
        form or with or subject to any modification, addition or condition approved
        or imposed by the Court.
	 	 	 	 

	
1.2      		
In this agreement, unless otherwise specified:	
	 
	 	
(A)      		
references to Clauses and sub-clauses are to clauses and sub-clauses of this agreement; and	
	 
	 	
(B)      		
headings to Clauses in this agreement are for convenience only and do not affect the interpretation of this agreement.	
	 
	
2.      		
CONDITIONS	
	 
	 	
This agreement shall be conditional in its entirety upon the Scheme of Arrangement becoming effective.	
	 
	
3.      		
AMENDMENT OF CONTRACT	
	 
	
3.1      		
It is hereby agreed that, with effect from the Effective Date, the Contract, with the exception of the exhibits thereto, shall be amended such that all references to Shire Pharmaceuticals Group plc in the Contract shall be
replaced with references to Shire plc. All relevant defined terms in the Contract shall be construed accordingly.	
	 
	
3.2      		
It is hereby agreed that, with effect from the Effective Date, the last sentence of clause 4.1(i) of the Contract shall be deleted and replaced with the following: “It is specifically agreed that the Executive shall be
reimbursed for the cost of the actual fuel incurred by him when he uses his private aircraft for travel in connection with the performance of his duties hereunder.”	
	 
	
4.      		
EFFECT OF THIS AGREEMENT	
	 
	
4.1      		
Prior to the Effective Date, the Contract (including its exhibits) shall continue in full force and effect in accordance with its current terms. With effect from the Effective Date, the Contract (including its exhibits) shall
continue in full force and effect as amended by this agreement. If the Scheme of Arrangement does not become effective on or before 31 March 2006, this agreement shall be null and void ab initio.	
	 
	
4.2      		
All salary, holiday entitlement and other benefits accrued and unpaid to the Director prior to the Effective Date, in respect of his service as Chief Executive of Shire Pharmaceuticals Group plc, shall, notwithstanding Clause
3, be carried forward and shall be deemed to apply after the Effective Date in respect of his service as Chief Executive of Shire plc.	
	 
	
4.3      		
The parties hereby acknowledge and agree that, for the purposes of clause 9 of the Contract, the interposition of Shire plc as the new holding company of Shire Pharmaceuticals Group plc pursuant to the Scheme of Arrangement
shall not constitute	
	 

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	 	 grounds for a termination of employment
      by the Director for Good Reason (as such term is defined in the Contract)
    or a Change of Control (as such term is defined in the Contract).
	 	 
	
4.4      		
Nothing in this agreement shall affect the remedies available either to the Director, or to the Company, whether under the Contract or otherwise, for any breach of, or default under, the Contract by either the Director or the
Company, as the case may be, prior to the Effective Date.	
	 
	
4.5      		
This agreement is to be binding on the parties notwithstanding clause 13.2 of the Contract.	
	 
	
5.      		
ENTIRE AGREEMENT	
	 
	 	
This agreement, together with the Contract, constitutes the whole and only agreement between the parties relating to the subject matter of this agreement. Each party acknowledges that, in entering into this agreement, it is
not relying on any pre- contractual statement which is not set out in this agreement or the Contract.	
	 
	
6.      		
COUNTERPARTS	
	 
	
6.1      		
This agreement may be executed in any number of counterparts, and by the parties on separate counterparts, but shall not be effective until each party has executed at least one counterpart.	
	 
	
6.2      		
Each counterpart shall constitute an original of this agreement, but all the counterparts shall together constitute but one and the same instrument.	
	 
	
7.      		
GOVERNING LAW AND JURISDICTION	
	 
	 	
The provisions of clause 14.6 of the Contract shall apply equally to this agreement mutatis mutandis as if set out in full in this agreement.	
	 

	 
	 
	

	
For and on behalf of 
	
	
SHIRE EXECUTIVE SERVICES INC. 
	
	 
	 
	

	
MR MATTHEW EMMENSExhibit 10.02 

RATIFICATION AND GUARANTY
        RELATING TO

  THE SERVICE CONTRACT OF MR MATTHEW EMMENS

	
1.      		
Interpretation	
	 
	
1.1      		
In this Ratification and Guaranty:	
	 

	“Agreement” 	 	means the amended and restated
        employment agreement relating to the employment of Matthew Emmens as
        Chairman of the Board of Directors and Chief Executive of Shire Executive
        Services Inc., Chief Executive Officer of Shire Pharmaceuticals Group
        plc and Chairman of the Board of Directors of Shire US Inc.,
        made between Shire Executive Services Inc. and Matthew Emmens and dated
        12th March
    2004, as such agreement may be amended from time to time;
	 	 	 
	“Amendment Agreement”	 	  means the agreement of even
        date with this Ratification and Guaranty between Shire Executive Services
        Inc. and Matthew Emmens pursuant to which certain provisions of the Agreement
    are amended; and
	 	 	 
	“Effective Date”	 	  means the date upon which
    the Amendment Agreement becomes effective in accordance with its terms.

	 	 
	
1.2      		
Unless expressly stated otherwise, all other defined terms in this Ratification and Guaranty shall have the same meaning as is given to them in the Agreement.	
	 
	
2.      		
Ratification and Guaranty	

Shire plc and Shire US Inc. (each a “Guarantor”) hereby confirm and ratify the Agreement and, with effect from the Effective Date, agree (i) to
the provisions thereof and (ii) to be bound by such provisions. For value received and to replace the ratification and guaranty given by Shire Pharmaceuticals Group plc and Shire US Inc. in respect of the Agreement, with effect from the Effective
Date, each Guarantor jointly and severally hereby irrevocably guarantees to the Executive the prompt performance and payment of all obligations of the Company to the Executive under the Agreement. This is a guarantee of performance and payment and
not of collection. The obligations of each Guarantor under this guarantee shall not be affected or impaired by reason of the happening from time to time of any of the following with respect to the Agreement: (i) the waiver by the Executive or the
Company of the performance or observance of any provision of the Agreement; (ii) the modification or amendment (whether material or otherwise) of any of the obligations of the Company or the Executive under the Agreement; (iii) any failure, omission
or delay on the part of the Executive to enforce, assert or exercise any right conferred on the Executive in the Agreement or otherwise; or (iv) any bankruptcy, insolvency or reorganization of, any arrangement or assignment for benefit of creditors
by, or any trusteeship with respect to, the Company or any of its assets. Each Guarantor specifically agrees to be subject to the arbitration and dispute resolution procedures set forth in Section 15.6 of the Agreement and to the jurisdiction of the
state and federal courts in the State of New York, agrees to be bound by an arbitrator’s determinations in any arbitration by the Company and the Executive, agrees not to assert arguments of forum non conveniens and agrees that 

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service upon it may be made by registered mail, return receipt requested. Each Guarantor shall require any successor (whether direct or indirect, by purchase, merger, consolidation or otherwise) to all or substantially all
its business, assets or stock to expressly assume this guarantee in writing delivered to the Executive and to fulfil the obligations hereunder as if no succession had taken place. Notwithstanding anything herein to the contrary, the obligations of
Shire plc under this Ratification and Guaranty shall not apply to any extent satisfaction of such obligations would cause Sections 309A (2) or (3), or Section 311 of the UK Companies Act of 1985 to be violated.

  	 SHIRE PLC  
	 	 	 
	By:	 
	 	

	 	Name:	 
	 	Title:	 
	 	 	 
	Dated:                      ,
          2005

  	 
	 
	 SHIRE US INC.  
	 	 	 
	By:	 
	 	

	 	Name:	 
	 	Title:	 
	 	 	 
	Dated:                      ,
          2005

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