Document:

EX-4.22

 Exhibit 4.22 

Rules of the Summit Therapeutics plc 
 2016 Long Term Incentive
Plan 
 Adopted by the board of directors of Summit Therapeutics plc on 21 January 2016 

Expiry date: 21 January 2026 

  
 1 

 Contents 
  

							
	1	 	DEFINITIONS AND INTERPRETATION	  	 	3	  
			
	2	 	GRANT OF AWARDS	  	 	5	  
			
	3	 	PERFORMANCE CONDITION	  	 	6	  
			
	4	 	RESTRICTIONS ON TRANSFER AND BANKRUPTCY	  	 	6	  
			
	5	 	DIVIDEND EQUIVALENTS	  	 	6	  
			
	6	 	INDIVIDUAL LIMIT	  	 	6	  
			
	7	 	PLAN LIMITS	  	 	7	  
			
	8	 	REDUCTION OF AWARDS AND CLAWBACK	  	 	8	  
			
	9	 	VESTING AND EXERCISE	  	 	9	  
			
	10	 	TAXATION AND REGULATORY ISSUES	  	 	10	  
			
	11	 	CASH EQUIVALENT/ NET SETTLEMENT	  	 	10	  
			
	12	 	CESSATION OF EMPLOYMENT	  	 	11	  
			
	13	 	CORPORATE EVENTS	  	 	13	  
			
	14	 	ADJUSTMENTS	  	 	15	  
			
	15	 	AMENDMENTS	  	 	15	  
			
	16	 	LEGAL ENTITLEMENT	  	 	15	  
			
	17	 	GENERAL	  	 	16	  
		
	SCHEDULE	  	 	17	  
			
	1	 	CASH AWARDS	  	 	17	  

  
 2 

 THE SUMMIT THERAPEUTICS PLC 2016 LONG TERM INCENTIVE PLAN 

 

	1	DEFINITIONS AND INTERPRETATION 

  

	1.1	In this Plan, unless otherwise stated, the words and expressions below have the following meanings: 

  

			
	 “Award”
	  	a Conditional Award or an Option (or a Cash Conditional Award or Cash Option granted under Schedule 1 to the Plan);
		
	 “AIM”
	  	a market operated by the London Stock Exchange;
		
	 “AIM Rules”
	  	the rules for companies whose share are admitted to trading on AIM published by the London Stock Exchange;
		
	 “Board”
	  	subject to Rule 13.10, the board of the Company or any duly authorised committee of the board;
		
	 “Company”
	  	Summit Therapeutics plc registered in England and Wales under number 05197494;
		
	 “Conditional Award”
	  	a right to acquire Shares subject to and in accordance with the Rules with no Exercise Period;
		
	 “Control”
	  	the meaning given by section 995 of the Income Tax Act 2007;
		
	 “Dealing Day”
	  	any day on which the London Stock Exchange is open for business;
		
	 “Dealing Restrictions”
	  	restrictions imposed by the Company’s share dealing code, the AIM Rules or any applicable laws or regulations which impose restrictions on share dealing;
		
	 “Eligible Employee”
	  	an employee (including an executive director) of the Company or any of its Subsidiaries;
		
	 “Exercise Period”
	  	the period during which an Option may be exercised, such period not to exceed ten years from the Grant Date;
		
	 “Exercise Price”
	  	in the case of an Option which has an Exercise Price, the price per Share payable to exercise the Option which, unless the Board determines otherwise, will be the Market Value of a Share on the Grant Date;
		
	 “Grant Date”
	  	the date on which an Award is granted;
		
	 “Group Member”
	  	the Company, any Subsidiary of the Company, any company which is (within the meaning of section 1159 of the Companies Act 2006) the Company’s holding company or a Subsidiary of the Company’s holding company or, if the
Board so determines, any body corporate in relation to which the Company is able to exercise at least 20% of the equity voting rights and “Group” will be construed accordingly;

  
 3 

			
	 “Internal Reorganisation”
	  	where immediately after a change of Control of the Company, all or substantially all of the issued share capital of the acquiring company is owned directly or indirectly by the persons who were shareholders in the Company
immediately before the change of Control;
		
	 “Market Value”
	  	 in relation to a Share on any day an amount equal to:
  

(i)     if and so long as the Shares are admitted to trading on AIM or a recognised stock
exchange, the closing price of a Share on AIM or a recognised stock exchange on (a) the Dealing Day immediately preceding the relevant date or, if the Board determines (b) the average middle market quotation of a Share for a number of Dealing Days
within a period not exceeding 5 days immediately preceding the relevant date provided that (b) shall not apply for the purpose of determining Market Value in Rule 11; or
  

(ii)    subject to (i) above, the market value of a Share as determined in accordance with Part
VIII Taxation of Chargeable Gains Act 1992 on the relevant date (or such earlier date as determined by the Board);

		
	 “Normal Vesting Date”
	  	 the date on which an Award will normally Vest, which:
  

(i)     in respect of an Award which is subject to the satisfaction of a Performance
Condition will be the later of:
  

(a)    the date on which the Board determines that the Performance Condition has been satisfied in
accordance with Rule 9.1; and
  

(b)    the third anniversary of the Grant Date,

 
 (or such other date determined by the Board and notified to the
Participant in accordance with Rule 2.3); and
  

(ii)    in respect of an Award which is not subject to the satisfaction of a Performance
Condition, the third anniversary of the Grant Date (or such other date determined by the Board and notified to the Participant in accordance with Rule 2.3);

		
	 “Option”
	  	a right to acquire Shares subject to and in accordance with the Rules during an Exercise Period;
		
	 “Participant”
	  	any person who holds an Award (or, in respect of Rules 8.4 and 8.6, any person to whom Shares have been issued or transferred or to whom cash is paid in respect of an Award) or following his death, his personal
representatives;
		
	 “Performance Condition”
	  	a condition or conditions imposed under Rule 3.1 which relates to performance;

  
 4 

			
	 “Performance Period”
	  	the period over which a Performance Condition will be measured which, unless the Board determines otherwise, will be at least three years;
		
	 “Plan”
	  	the Summit Therapeutics plc 2016 Long Term Incentive Plan in its present form or as from time to time amended;
		
	 “Rules”
	  	the rules of the Plan, as set out in this document and “Rule” will be construed accordingly;
		
	 “Share”
	  	a fully paid ordinary share in the capital of the Company;
		
	 “Subsidiary”
	  	the meaning given by section 1159 of the Companies Act 2006;
		
	 “Tax Liability”
	  	any tax or social security contributions liability in connection with an Award for which the Participant is liable and for which any Group Member or former Group Member is obliged to account to any relevant authority (including,
without limitation, any secondary Class 1 (employer’s) national insurance contributions covered by any agreement or election entered into pursuant to Rule 2.5, but excluding any secondary Class 1 (employer’s national insurance
contributions which are not covered by such an agreement or election));
		
	 “Trustee”
	  	the trustee or trustees for the time being of any employee benefit trust, the beneficiaries of which include Eligible Employees; and
		
	 “Vest”
	  	 (i)     in relation to a Conditional Award, the point at which a
Participant becomes entitled to receive the Shares under his Award in accordance with the Rules ; and
  

(ii)    in relation to an Option, the point at which it becomes capable of exercise in accordance
with the Rules ,
  
 and “Vesting”, “Vesting Date”,
“Vested” and “Unvested” will be construed accordingly.

  

	1.2	References in the Plan to: 

  

	 	1.2.1	any statutory provisions are to those provisions as amended or re-enacted from time to time; 

  

	 	1.2.2	the singular include the plural and vice versa; and 

  

	 	1.2.3	the masculine include the feminine and vice versa. 

  

	1.3	Headings do not form part of the Plan. 

  

	2	GRANT OF AWARDS 

  

	2.1	Subject to Rule 2.2, during a Grant Period, the Board may grant an Award to an Eligible Employee in its discretion subject to the Rules and upon such additional terms as the Board may determine. 

  
 5 

	2.2	The grant of an Award will be subject to obtaining any approval or consent required by any relevant authority), any Dealing Restrictions and any other applicable laws or regulations (whether in the UK or overseas).

  

	2.3	Awards must be granted by deed (or in such other written form as the Board determines) and, as soon as reasonably practicable after the Grant Date, Participants must be notified of the terms of their Award including any
Performance Condition and such additional terms as it may consider appropriate. 

  

	2.4	No Award may be granted under the Plan after the tenth anniversary of the date on which the Plan was adopted by the Board. 

  

	2.5	The Board may make the exercise of an Option or Vest of a Conditional Award conditional upon the Participant having entered into an agreement or election pursuant to paragraphs 3A or 3B of Schedule 1 to the Social
Security Contributions and Benefits Act 1992. 

  

	3	PERFORMANCE CONDITION 

  

	3.1	Unless the Board determines otherwise, the Vest of Awards will be subject to the satisfaction of a Performance Condition. Subject to Rules 12 and 13, the Performance Condition will be measured over the Performance
Period. 

  

	3.2	The Board may amend or substitute a Performance Condition if one or more events occur which cause the Board to consider that a substituted or amended Performance Condition would be more appropriate and would not be
materially less difficult to satisfy. 

  

	4	RESTRICTIONS ON TRANSFER AND BANKRUPTCY 

  

	4.1	An Award must not be transferred, assigned, charged or otherwise disposed of in any way (except in the event of the Participant’s death, to his personal representatives) and will lapse immediately on any attempt to
do so. 

  

	4.2	An Award will lapse immediately if the Participant is declared bankrupt or, if the Participant is outside the UK, any analogous event occurs. 

 

	5	DIVIDEND EQUIVALENTS 

  

	5.1	The Board may decide at any time prior to the issue or transfer of the Shares in respect of an Award that has Vested that the Participant will receive an amount (in cash and/or additional Shares) equal in value to any
dividends that would have been paid on those Shares on such terms and over such period (ending no later than the Vest Date) as the Board may determine. This amount may assume the reinvestment of dividends (on such basis as the Board may determine)
and may exclude or include special dividends. 

  

	5.2	Any such amount will be payable as soon as reasonably practicable after Vest or, in the case of an Option, exercise, of the relevant Award. 

 

	6	INDIVIDUAL LIMIT 

  

	6.1	No Eligible Employee may be granted an Award which would, at the time it is granted, cause the market value (as determined by the Board) of all the Shares subject to Awards granted to that Eligible Employee in respect
of a particular financial year of the Company to exceed ten times his annual base salary and to the extent any Award exceeds this limit it will be scaled back accordingly. 

  
 6 

	7	PLAN LIMITS 

  

	7.1	The Board must not grant an Award which would cause the number of Shares allocated under the Plan and under any other employee share plan adopted by the Company to exceed such number as represents fifteen per cent of
the ordinary share capital of the Company in issue at that time. 

  

	7.2	Subject to Rules 7.3 and 7.4, in determining the limits set out in Rule 7.1 Shares are treated as allocated if they have been newly issued by the Company or transferred from treasury to satisfy an option, award or other
right granted during the ten years prior to the proposed Grant Date (an “award”), or in the case of such an award in respect of which Shares are yet to be delivered, if the Board intends that new Shares will be issued or that Shares from
treasury will be transferred and for these purposes the number of Shares allocated includes: 

  

	 	7.2.1	Shares which have been issued or may be issued to any Trustee; and 

  

	 	7.2.2	Shares which have been or may be transferred from treasury to any Trustee 

 in either case for
the Trustee to then transfer to satisfy an award (unless these Shares have already been counted under this Rule). 
  

	7.3	The Board may determine that Shares transferred from treasury will cease to count as allocated for the purposes of Rule 7.2 if guidelines published by institutional investor representative bodies no longer require such
Shares to be counted. 

  

	7.4	The number of Shares allocated does not include: 

  

	 	7.4.1	Shares in respect of which the right to acquire such Shares lapses or is released; and 

  

	 	7.4.2	existing Shares other than treasury Shares which are transferred or to which an award relates; and 

  

	 	7.4.3	Shares allocated in respect of awards which are then satisfied in cash. 

  

	7.5	If the Board purports to grant one or more Awards which are inconsistent with the limits in this Rule 7: 

  

	 	7.5.1	if only one Award is purported to be so granted, that Award will be limited and will take effect from the Grant Date over the maximum number of Shares permitted by those limits; and 

 

	 	7.5.2	if more than one Award is purported to be so granted, each such Award will be reduced as determined by the Board and will take effect from the Grant Date over the maximum number of Shares permitted by those limits.

  

	7.6	The Board may make such adjustments to the method of assessing the limits set out in Rules 7.1 and 7.2 as it considers appropriate in the event of any variation of the Company’s share capital. 

  
 7 

	8	REDUCTION OF AWARDS AND CLAWBACK 

  

	8.1	Notwithstanding any other Rule, the Board may, in its discretion and taking into account all relevant factors including the Participant’s level of responsibility, determine that the provisions of either or both
Rules 8.3 and 8.4 should be applied in respect of any Award if: 

  

	 	8.1.1	in the case of the provisions of Rule 8.3, any of the circumstances described in Rule 8.2 have occurred; and 

  

	 	8.1.2	in the case of the provisions of Rule 8.4, any of the circumstances described in Rules 8.2.1 or 8.2.4 have occurred, 

within the period beginning on the Grant Date (or, in relation to an Award which is subject to a Performance Condition, the first day of the
Performance Period) or such earlier date as the Board determines on or before the Grant Date and ending on the later of second anniversary of Vesting or fifth anniversary of the Grant Date, or such longer period as is required under US Securities
and Exchange Commission (“SEC”) rules that are applicable to the Company. 
  

	8.2	The circumstances referred to in Rule 8.1 are: 

  

	 	8.2.1	a material misstatement of the Group’s audited financial results; 

  

	 	8.2.2	a material failure of risk management by the Company, any other Group Member or a relevant business unit; 

  

	 	8.2.3	serious reputational damage to the Company, any other Group Member or a relevant business unit; 

  

	 	8.2.4	material misconduct on the part of the Participant; or 

  

	 	8.2.5	any other circumstances which the Board in its discretion considers to be similar in their nature or effect. 

  

	8.3	The Board may, in its discretion, determine at any time prior to the Vest of an Award to: 

  

	 	8.3.1	reduce (including to zero) the number of Shares to which an Award relates or may relate; and/or 

  

	 	8.3.2	impose further conditions on an Award. 

  

	8.4	The Board may, in its discretion, determine that at any time after the Vesting of an Award and prior to the later of the second anniversary of Vesting and the fifth anniversary of the Grant Date (or such longer period
as is required by SEC rules that are applicable to the Company) to: 

  

	 	8.4.1	take the action referred to in Rule 8.3.1 or 8.3.2 if a Vested Option has not yet been exercised, or if Shares or cash have not yet been delivered to the Participant following the Vesting of a Conditional Award or
exercise of an Option; and/or 

  

	 	8.4.2	require a Participant or former Participant to make a cash payment to the Company in respect of some or all of the Shares or cash delivered to him under the Award; and/or 

 

	 	8.4.3	require a Participant or former Participant to transfer for nil consideration some or all of the Shares delivered to him under the Award 

  
 8 

 and the Board will have discretion to determine the basis on which the amount of cash or Shares
is calculated including whether and if so to what extent to take account of any tax or social security liability applicable to the Award. 
  

	8.5	If the action or conduct of any Participant, Group Member or relevant business unit is under investigation prior to the second anniversary of the Vest Date pursuant to this Rule 8 and such investigation has not yet been
concluded by that date, the period referred to in Rule 8.4 will end on such later date as the Board considers appropriate to allow such investigation to be concluded. 

 

	8.6	The Board may decide to: 

  

	 	8.6.1	reduce (including to zero) the number of Shares to which an Award relates or may relate; 

  

	 	8.6.2	impose further conditions on an Award; and/or 

  

	 	8.6.3	require a Participant to transfer for nil consideration some or all of the Shares delivered to him under an Award or make a cash payment to the Company in respect of some or all of the Shares delivered to him under an
Award 

 to effect the recovery of sums paid or Shares delivered under any provisions similar to this Rule 8 which are included
in any bonus plan or share plan (other than the Plan) operated by any Group Member and if the Board decides to apply Rule 8.6.3 the Board will have the discretion to determine the basis on which the amount of cash or Shares is calculated including
whether and if so to what extent to take account of any tax or social security liability applicable to the Award. 
  

	8.7	For the purposes of this Rule 8, references to Group Member or a relevant business unit include references to any former Group Member or former business unit. 

 

	8.8	If the Board exercises its discretion in accordance with this Rule 8, it will confirm this in writing to each Participant and, if necessary, the Trustee. 

 

	9	VESTING AND EXERCISE 

  

	9.1	As soon as reasonably practicable after the end of the Performance Period relating to an Award in respect of which a Performance Condition has been imposed, the Board will determine if and to what extent the Performance
Condition has been satisfied. To the extent that the Performance Condition has not been satisfied in full, the remainder of the Award will lapse immediately. 

  

	9.2	Subject to Rules 10, 12 and 13, an Award will Vest: 

  

	 	9.2.1	on the Normal Vesting Date; or 

  

	 	9.2.2	if on the Normal Vesting Date (or on any other date on which an Award is due to Vest under Rules 12 or 13) a Dealing Restriction applies to the Award, on the date on which such Dealing Restriction lifts; and

 an Option may then be exercised in accordance with Rules 9.3 to 9.5 until the tenth anniversary of the Grant Date (or such
earlier date as the Board may determine on or prior to the Grant Date) in such manner as the Board determines, after which time it will lapse. 

  
 9 

	9.3	To exercise an Option, a Participant must pay the aggregate Exercise Price (if any) for the Shares in respect of which he is exercising the Option, or enter into arrangements acceptable to the Board to pay that amount.

  

	9.4	Subject to Rules 9.5 and 10, an Option may be exercised pursuant to this Rule 9 or Rules 12 and 13 in such form and manner as the Board may determine, provided that exercise of an Option will not take effect until the
Company receives: 

  

	 	9.4.1	a notice of exercise of the Option; and 

  

	 	9.4.2	payment of the aggregate Exercise Price (if any), or an undertaking to pay that amount. 

  

	9.5	Options may be exercised in whole or in part. 

  

	9.6	Subject to Rules 10 and 11, where a Conditional Award has Vested or an Option has been exercised, the number of Shares in respect of which the Award has Vested or been exercised together with any additional Shares or
cash to which a Participant becomes entitled under Rule 5 will be issued, transferred or paid (as applicable) to the Participant as soon as reasonably practicable thereafter. 

 

	10	TAXATION AND REGULATORY ISSUES 

  

	10.1	A Participant will be responsible for and indemnifies each relevant Group Member and the Trustee against any Tax Liability relating to his Award. Any Group Member and/or the Trustee may withhold an amount equal to such
Tax Liability from any amounts due to the Participant (to the extent such withholding is lawful) and/or make any other arrangements as it considers appropriate to ensure recovery of such Tax Liability including, without limitation, the sale of
sufficient Shares acquired subject to the Award to realise an amount equal to the Tax Liability. 

  

	10.2	The Vest of an Award, the exercise of an Option and the issue or transfer of Shares under the Plan will be subject to obtaining any approval or consent required by any relevant authority, any Dealing Restrictions or any
other applicable laws or regulations (whether in the UK or overseas). 

  

	11	CASH EQUIVALENT/ NET SETTLEMENT 

  

	11.1	Subject to Rule 11.4, at any time prior to the date on which Shares in respect of an Award that has been Vested or exercised have been issued or transferred to a Participant, the Board may determine that, in
substitution for his right to acquire some or all of the Shares to which his Award relates, the Participant will instead receive a cash sum in accordance with Rule 11.2 or a reduced number of Shares in accordance with Rule 11.3. 

 

	11.2	A cash sum to which a Participant becomes entitled under this Rule 11.2 will be equal to the market value (as determined by the Board) of that number of Shares which would otherwise have been issued or transferred,
less, in the case of an Option, the aggregate Exercise Price payable (if any) in respect of the exercise of the Option in relation to those Shares and for these purposes: 

 

	 	11.2.1	in the case of a Conditional Award, market value will be determined on the Vest Date; 

  

	 	11.2.2	in the case of an Option, market value will be determined on the date of exercise; and 

  
 10 

	 	11.2.3	the cash sum will be paid to the Participant as soon as reasonably practicable after the Vest or exercise of the Award (or, if later, the date of such determination) net of any deductions (including but not limited to,
any Tax Liability or similar liabilities) as may be required by law. 

  

	11.3	The number of Shares to which a Participant becomes entitled under this Rule 11.3 will be equal to the market value (as determined by the Board) of that number of Shares which would otherwise have been issued or
transferred, less (if the Board determines) any deductions (including, but not limited to, any Tax Liability or similar liabilities) as may be required by law in respect of the Award in relation to those Shares and, in the case of an Option, the
aggregate Exercise Price payable (if any) in respect of the Option in relation to those Shares and for these purposes: 

  

	 	11.3.1	in the case of a Conditional Award, market value will be determined on the Vest Date; 

  

	 	11.3.2	in the case of an Option, market value will be determined on the date of exercise; and 

  

	 	11.3.3	the number of Shares to which a Participant is entitled will be issued or transferred to him as soon as reasonably practicable after the Vest of the Conditional Award or the exercise of the Option. 

 

	11.4	The Board may determine that this Rule 11 will not apply to an Award, or any part of it 

  

	12	CESSATION OF EMPLOYMENT 

 Death 

 

	12.1	If a Participant dies, unless the Board determines otherwise, an Award which has not Vested at the date of his death will Vest as soon as practicable thereafter in accordance with Rule 12.2. 

 

	12.2	The number of Shares in respect of which an Award Vests pursuant to Rule 12.1 will be determined by the Board in its discretion, taking into account: 

 

	 	12.2.1	unless the Board determines otherwise, the extent to which any Performance Condition has been satisfied at the date of death; and 

  

	 	12.2.2	unless the Board determines otherwise, the period of time that has elapsed from the start of the Performance Period to the date of death as a proportion of the Performance Period or if the Award is not subject to a
Performance Condition, the Grant Date to the date of death, or such other period of time as the Board determines, 

 and to the
extent that an Award does not Vest in full, the remainder will lapse immediately. 
  

	12.3	An Option which Vests in accordance with Rule 12.1 or which was already Vested at the date of death may then be exercised, subject to Rule 13, during the period of 12 months from the later of the date of death and
the date of Vesting (or such other period as the Board may determine), after which time it will lapse. 

 Cessation of
employment prior to the Vesting Date 
  

	12.4	If a Participant ceases to hold office or employment with a Group Member prior to the Vesting Date other than in accordance with Rule 12.1 or 12.5, his Award will lapse at that time. 

  
 11 

	12.5	If a Participant ceases to hold office or employment with a Group Member prior to the Vesting Date as a result of: 

  

	 	12.5.1	ill-health, injury or disability as established to the satisfaction of the Board; 

  

	 	12.5.2	redundancy or retirement with the agreement of the Participant’s employing company; 

  

	 	12.5.3	the Participant’s employing company ceasing to be a Group Member or the transfer of an undertaking or part of an undertaking (in which the Participant is employed) to a person who is not a Group Member; or

  

	 	12.5.4	any other reason at the Board’s discretion, except where a Participant is summarily dismissed, 

unless the Board determines that an Award will Vest in accordance with Rule 12.6, an Award will continue and, subject to it Vesting and lapsing
earlier under Rule 13, will Vest in accordance with Rule 12.7 on the Normal Vesting Date. 
  

	12.6	If the Board determines that an Award will Vest in accordance with this Rule 12.6, it will Vest in accordance with Rule 12.7 as soon as reasonably practicable following the date of the Participant’s cessation of
office or employment (or on such other date as determined by the Board). 

  

	12.7	The number of Shares in respect of which the Award Vests pursuant to Rule 12.5 or 12.6 will be determined by the Board in its discretion, taking into account: 

 

	 	12.7.1	unless the Board determines otherwise, the extent to which any Performance Condition has been satisfied at the end of the Performance Period (if Rule 12.5 applies) or at the date of the Participant’s cessation of
office or employment (if Rule 12.6 applies); and 

  

	 	12.7.2	unless the Board determines otherwise, the period of time that has elapsed from the start of the Performance Period to the date of cessation of office or employment as a proportion of the Performance Period or if the
Award is not subject to a Performance Condition, the Grant Date to the date of cessation of office or employment, or such other period of time as the Board determines, 

and to the extent that an Award does not Vest in full, the remainder will lapse immediately. 

 

	12.8	An Option may be exercised, subject to it lapsing earlier under Rule 13, for a period of six months (or such other period as the Board may determine) from the Vest Date after which time it will lapse. 

Cessation of employment – Options which have Vested but not been exercised 

 

	12.9	Subject to Rules 12.3 and 12.10, if a Participant ceases to hold office or employment with a Group Member on or after the Vesting Date, his Option will lapse at that time. 

 

	12.10	Subject to Rule 12.3, if a Participant ceases to hold office or employment with a Group Member on or after the Vesting Date as a result of resignation by the Participant from such office or employment or an event listed
in Rules 12.5.1 to 12.5.4 an Option which has Vested prior to the date of cessation may be exercised, subject to it lapsing earlier under Rule 13, for a period of six months (or such other period as the Board may determine) from the date of such
cessation, after which time it will lapse. 

  

	12.11	For the purposes of the Plan, no person will be treated as ceasing to hold office or employment with a Group Member until that person no longer holds: 

 

	 	12.11.1	an office or employment; or 

  
 12 

	 	12.11.2	a right to return to work 

 with any Group Member. 

 

	13	CORPORATE EVENTS 

  

	13.1	Where any of the events described in Rule 13.3 occur, subject to Rules 13.8 and 13.9, all Awards which have not yet Vested will Vest in accordance with Rule 13.2 at the time of such event unless they are Vested earlier
in accordance with Rule 13.5. Options will be exercisable for three months (or such other period as the Board may determine) from the date of the relevant event, after which time all Options will lapse. 

 

	13.2	Any Unvested Award will be Vested pursuant to Rule 13.1 to the extent determined by the Board in its discretion, taking into account, unless the Board determines otherwise the extent to which any Performance Condition
has, in the Board’s opinion, been satisfied and, unless the Board determines otherwise, the period of time that has elapsed from the Grant Date to the date of the relevant event (or the date of cessation of office or employment if earlier). To
the extent that an Award does not Vest, or is not exchanged in accordance with Rules 13.8 and 13.9, it will lapse immediately. 

  

	13.3	The events referred to in Rule 13.1 are: 

  

	 	13.3.1	General offer 

 If any person (either alone or together with any person acting in concert with
him): 
  

	 	13.3.1.1	obtains Control of the Company as a result of making a general offer to acquire Shares; or 

  

	 	13.3.1.2	already having Control of the Company, makes an offer to acquire all of the Shares other than those which are already owned by him and such offer becomes wholly unconditional. 

 

	 	13.3.2	Scheme of arrangement 

 A compromise or arrangement in accordance with section 899 of the
Companies Act 2006 for the purposes of a change of Control of the Company is sanctioned by the Court. 
  

	13.4	If a person becomes bound or entitled to acquire Shares under sections 979 to 982 or 983 to 985 of the Companies Act 2006 (takeover offers: right of offeror to buy out minority shareholder etc.), any Option which has
not already been exercised or lapsed may be exercised (to the extent permitted by Rule 13.2) while that person remains so bound or entitled. All unexercised Options will lapse when that person ceases to be so bound or entitled. 

 

	13.5	Loss of corporation tax deduction 

 If the Board determines that there would be a loss of
corporation tax deduction under Part 12 of the Corporation Tax Act 2009 (or any similar legislation or rules in a jurisdiction outside the United Kingdom) if Awards were to Vest or Options were to be exercised on or after an event described in Rule
13.3 or 13.4, then the Board may resolve that Awards will Vest at an earlier date. 

  
 13 

	13.6	Winding-up 

 On the passing of a resolution for the voluntary winding-up or the making of an
order for the compulsory winding up of the Company, the Board will determine: 
  

	 	13.6.1	whether and to what extent Awards which have not yet Vested will Vest taking into account the extent, unless the Board determines otherwise to which any Performance Condition has, in the Board’s opinion, been
satisfied and, unless the Board determines otherwise, the period of time that has elapsed from the start of the Grant Date to the date of the relevant event (or the date of cessation of office or employment if earlier), or such other period as the
Board may determine; and 

  

	 	13.6.2	the period of time during which any Vested Option may be exercised, after which time it will lapse. 

To the extent that an Award does not Vest it will lapse immediately. 
  

	13.7	Other events 

 If the Company is or may be affected by a demerger, delisting, special dividend
or other event and in the opinion of the Board, may affect the current or future value of Shares to a material extent and the Board determines it would not be appropriate or practical to adjust Awards in accordance with Rule 14 the Board may
determine that the following provisions will apply: 
  

	 	13.7.1	an Award will Vest on such terms as the Board may determine; 

  

	 	13.7.2	if an Award Vests under this Rule 13.7, it will Vest taking into account the extent, unless the Board determines otherwise to which any Performance Condition has in the Board’s opinion been satisfied and, unless
the Board determines otherwise, the period of time that has elapsed from the Grant Date to the date of the relevant event (or the date of cessation of office or employment if earlier), or such other period as the Board may determine; and

  

	 	13.7.3	the Board will determine the period during which any Vested Option may be exercised, after which time it will lapse. 

To the extent that the Award does not Vest it will lapse immediately, unless the Board determines otherwise. 

 

	13.8	Exchange 

 An Award will not Vest under Rule 13.1 but will be exchanged on the terms set out in
Rule 13.9 to the extent that: 
  

	 	13.8.1	an offer to exchange the Award (the “Existing Award”) is made and accepted by a Participant; 

  

	 	13.8.2	there is an Internal Reorganisation, unless the Board determines that an Award should Vest under Rule 13.1; or 

  

	 	13.8.3	the Board decides (before the relevant event) that an Existing Award will be exchanged automatically. 

  
 14 

	13.9	Exchange terms 

 If this Rule 13.9 applies, the Existing Award will not Vest but will be
exchanged in consideration of the grant of a new award which, in the opinion of the Board, is equivalent to the Existing Award, but relates to shares in a different company (whether the acquiring company or a different company). 

 

	13.10	Meaning of Board 

 Any reference to the Board in this Rule 13 means the members of the Board
immediately prior to the relevant event. 
  

	14	ADJUSTMENTS 

  

	14.1	The number of Shares subject to an Award, any Performance Condition and /or the Exercise Price (if any) of an Option may be adjusted in such manner as the Board determines, in the event of: 

 

	 	14.1.1	any variation of the share capital of the Company; or 

  

	 	14.1.2	a demerger, delisting, special dividend or other event which may, in the opinion of the Board, affect the current or future value of Shares. 

 

	15	AMENDMENTS 

  

	15.1	Except as described in this Rule 15, the Board may at any time amend the Rules or, subject to Rule 3.2 the terms of any Award. 

  

	15.2	An amendment that is to the material disadvantage of the existing rights of a Participant will not be made under Rule 15.1 unless the Participant has approved the amendment. 

 

	15.3	No amendment will be made under this Rule 15 if it would prevent the Plan from being an employees’ share scheme in accordance with section 1166 of the Companies Act 2006. 

 

	16	LEGAL ENTITLEMENT 

  

	16.1	This Rule 16 applies during a Participant’s employment with any Group Member and after the termination of such employment, whether or not the termination is lawful. 

 

	16.2	Nothing in the Plan or its operation forms part of the terms of employment of a Participant and the rights and obligations arising from a Participant’s employment with any Group Member are separate from, and are
not affected by, his participation in the Plan. Participation in the Plan does not create any right to continued employment with a Group Member for any Participant. 

 

	16.3	The grant of any Award to a Participant does not create any right for that Participant to be granted any further Awards or to be granted Awards on any particular terms, including the number of Shares to which Awards
relate. 

  

	16.4	By participating in the Plan, a Participant waives all rights to compensation for any loss in relation to the Plan, including: 

  

	 	16.4.1	any loss or reduction of any rights or expectations under the Plan in any circumstances or for any reason (including lawful or unlawful termination of the Participant’s employment); 

  
 15 

	 	16.4.2	any exercise of a discretion or a decision taken in relation to an Award or to the Plan, or any failure to exercise a discretion or take a decision; and 

 

	 	16.4.3	the operation, suspension, termination or amendment of the Plan. 

  

	17	GENERAL 

  

	17.1	The Plan will terminate upon the date stated in Rule 2.4, or at any earlier time by the passing of a resolution by the Board or an ordinary resolution of the Company in general meeting. Termination of the Plan will be
without prejudice to the existing rights of Participants. 

  

	17.2	Shares issued or transferred from treasury under the Plan will rank equally in all respects with the Shares then in issue, except that they will not rank for any voting, dividend or other rights attaching to Shares by
reference to a record date preceding the date of issue or transfer from treasury. 

  

	17.3	By participating in the Plan, a Participant consents to the collection, holding, processing and transfer of his personal data by any Group Member or any third party for all purposes relating to the operation of the
Plan, including but not limited to, the administration and maintenance of Participant records, providing information to future purchasers of the Company or any business in which the Participant works and the transfer of information about the
Participant to a country or territory outside the European Economic Area or elsewhere. 

  

	17.4	The Plan will be administered by the Board. The Board will have full authority, consistent with the Plan, to administer the Plan, including authority to interpret and construe any provision of the Plan and to adopt
regulations for administering the Plan. Decisions of the Board will be final and binding on all parties. 

  

	17.5	Any notice or other communication in connection with the Plan may be delivered personally or sent by electronic means or post, in the case of a company to its registered office (for the attention of the company
secretary), and in the case of an individual to his last known address, or, where he is a director or employee of a Group Member, either to his last known address or to the address of the place of business at which he performs the whole or
substantially the whole of the duties of his office or employment. Where a notice or other communication is given by post, it will be deemed to have been received 72 hours after it was put into the post properly addressed and stamped, and if by
electronic means, when the sender receives electronic confirmation of delivery or if not available, 24 hours after sending the notice. 

  

	17.6	No third party will have any rights under the Contracts (Rights of Third Parties) Act 1999 to enforce any term of the Plan (without prejudice to any right of a third party which exists other than under that Act).

  

	17.7	The Rules will be governed by and construed in accordance with the laws of England and Wales. Any person referred to in the Plan submits to the exclusive jurisdiction of the Courts of England and Wales.

  
 16 

 SCHEDULE 1 

CASH AWARDS 
  

	1	CASH AWARDS 

 The Rules of the Summit Therapeutics plc 2016 Long-Term Incentive Plan will apply to
a right to receive a cash sum granted under this Schedule as if it was either a Conditional Award (a “Cash Conditional Award”) or an Option (a “Cash Option”), except as set out in this Schedule. Where there is any
conflict between the Rules and this Schedule, the terms of this Schedule will prevail. 
  

	 	1.1	Each Cash Conditional Award or Cash Option will relate to a certain number of notional Shares. 

  

	 	1.2	On the Vest of a Cash Conditional Award or the exercise of a Cash Option the Participant will be entitled to receive a cash sum, calculated by reference to the value of the number of notional Shares to which the Cash
Conditional Award or the Cash Option relates, on the following basis: 

  

	 	1.2.1	in the case of a Cash Conditional Award the cash sum will be equal to the market value (as determined by the Board) of the notional Shares to which the Cash Conditional Award relates on the Vest Date; and

  

	 	1.2.2	in the case of a Cash Option the cash sum will be equal to the market value (as determined by the Board) of the notional Shares to which the Cash Option relates on the date of exercise less the aggregate Exercise Price
payable (if any) in respect of the exercise of the Cash Option in relation to the notional shares. 

  

	 	1.3	The cash sum payable under paragraph 1.2 above will be paid to the Participant as soon as reasonably practicable after the Vest of the Cash Conditional Award or the exercise of the Cash Option, net of any deductions
(including, but not limited to, any Tax Liability or similar liabilities) as may be required by law. 

  

	 	1.4	A Cash Conditional Award or Cash Option will not confer any right on the holder to receive Shares or any interest in Shares. 

  
 17 

 SCHEDULE 2 

CSOP OPTIONS 
 This Schedule constitutes
the “Summit Therapeutics plc 2016 Company Share Option Plan (the “CSOP”) and sets out the terms on which the Board may grant CSOP Options. 

The purpose of this CSOP is to enable the Company to grant CSOP Options to Eligible Employees in accordance with ITEPA Schedule 4. No CSOP Options may be
granted under this Schedule other than in accordance with ITEPA Schedule 4, and no other form of Award may be granted under this Schedule. 
  

	1.	INTERPRETATION 

  

	1.1	References in this Schedule to ‘Rules’ are to rules of the Plan and references to ‘Sections’ are to the sections of this Schedule. 

 

	1.2	The Rules apply to CSOP Options except as modified below and references in the Rules to an Award or Option will be interpreted as references to a CSOP Option for the purposes of this Schedule. 

 

	1.3	In the event of any conflict between the Rules and the Sections of this Schedule, this Schedule shall take precedence. 

  

	2.	DEFINITIONS 

  

	2.1	For the purposes of this Schedule, the following definitions shall apply: 

  

			
	“Associated Company”	  	has the meaning given to it in paragraph 35(1) of ITEPA ITEPA Schedule 4;
		
	“CSOP Limit”	  	the limit specified from time to time under paragraph 6(1) of ITEPA Schedule 4;
		
	“CSOP Option”	  	an Option granted under this Schedule;
		
	“HMRC”	  	HM Revenue & Customs;
		
	“ITEPA Schedule 4”	  	Schedule 4 to the Income Tax (Earnings and Pensions) Act 2003;
		
	“Market Value”	  	in relation to a share on any day an amount equal to its market value determined in accordance with Part VIII Taxation of Chargeable Gains Act 1992 on the relevant date;
		
	“Restriction	  	has the meaning given by paragraph 36(3) of ITEPA Schedule 4; and

  
 1 

			
	“Variation of Capital”	  	in relation to the equity share capital of the Company, a capitalisation issue, an offer or invitation made by way of rights, a subdivision, consolidation, reduction or any other variation in respect of which a CSOP Option may be
adjusted in accordance with the requirements of ITEPA Schedule 4.

  

	3.	ELIGIBILITY TO BE GRANTED AN APPROVED OPTION 

  

	3.1	A CSOP Option may only be granted to an Eligible Employee who is a director of the Company or any of its Subsidiaries if he is obliged to devote not less than 25 hours a week (excluding meal breaks) to the performance
of the duties of his office or employment with the Company or Subsidiary. 

  

	3.2	A CSOP Option may not be granted to an Eligible Employee who is excluded from participation by virtue of paragraph 9 of ITEPA Schedule 4 (material interest in a close company). 

 

	4.	GRANT OF A CSOP OPTION 

  

	4.1	The Exercise Price of a CSOP Option must not be less than the Market Value of a Share at the Grant Date. 

  

	4.2	Each CSOP Option shall be granted in such a manner as to constitute a legal right to acquire the Shares subject to the CSOP Option, subject to the terms of this Schedule. 

 

	4.3	The Board must not grant a CSOP Option to an Eligible Employee which would on the Grant Date cause the aggregate Market Value of the Shares which he may acquire by exercising that CSOP Option, any other CSOP Option or
any other option which is to be taken into account for the purposes of the CSOP Limit, to exceed the amount permitted from time to time under the CSOP Limit. 

  

	4.4	If a CSOP Option is purported to be granted in breach of the CSOP Limit, that CSOP Option shall take effect from the Grant Date over the maximum number of Shares over which it may be granted within that limit.

  

	4.5	For the purposes of this Section 4: 

  

	 	4.5.1	the Market Value of a Share will be determined at the Grant Date of the relevant option; and 

  

	 	4.5.2	the Market Value of a Share subject to a Restriction will be determined as if the Restriction did not apply. 

  

	5.	SHARES SUBJECT TO A CSOP OPTION 

  

	5.1	The Shares subject to a CSOP Option must satisfy the conditions referred to in paragraph 15 of ITEPA Schedule 4. 

  
 2 

	6.	INFORMATION TO BE PROVIDED TO PARTICIPANTS 

  

	6.1	As soon as reasonably practicable following the grant of a CSOP Option, the Participant shall be informed of: 

  

	 	6.1.1	the Exercise Price; 

  

	 	6.1.2	the number and description of Shares which may be acquired on the exercise of a CSOP Option; 

  

	 	6.1.3	any Restrictions to which those Shares are subject; 

  

	 	6.1.4	the times at which the CSOP Option may be exercised (in whole or in part); and 

  

	 	6.1.5	the circumstances under which the CSOP Option will lapse or be cancelled (in whole or in part). 

  

	7.	VESTING AND EXERCISE OF CSOP OPTIONS 

  

	7.1	A Participant may not exercise a CSOP Option while he is excluded from being granted a CSOP Option under paragraph 9 of ITEPA Schedule 4 (material interest in a close company). 

 

	7.2	Rule 5 (Dividend Equivalents) shall not apply to any CSOP Options. 

  

	7.3	Rule 10.1 shall not apply to CSOP Options. A Participant will be responsible for and indemnify each relevant Group Member and/or the Trustee against any Tax Liability arising as a result of the exercise of a CSOP Option
and will reimburse the Group Member and/or the Trustee (as relevant) for the Tax Liability within thirty days of it arising. A CSOP Option may only be exercised if there are arrangements in place acceptable to the Board to provide for the
reimbursement of any Tax Liability arising as a result of the exercise of the CSOP Option, which may include: 

  

	 	7.3.1	the Participant making a payment to the Group Member and/or the Trustee; 

  

	 	7.3.2	the Group Member withholding the Tax Liability from the Participant’s remuneration (to the extent permitted by law); or 

  

	 	7.3.3	with the Participant’s agreement, any other arrangement acceptable to the Group Member and/or the Trustee to reimburse the Tax Liability, including authorising the sale of sufficient of the Shares on the
Participant’s behalf. 

  

	8.	CASH EQUIVALENT / NET SETTLEMENT 

  

	8.1	Rule 11 of the Plan shall not apply to CSOP Options. 

  

	9.	CESSATION OF EMPLOYMENT 

  

	9.1	Rule 12 of the Plan shall be deleted and replaced by this Section 9 and in the case of CSOP Options, any reference within the Plan to Rule 12 shall be read as referring to Section 9. 

 

	9.2	Subject to Sections 9.3, 9.6 and 9.9, if a Participant ceases to hold office or employment with a Group Member his CSOP Option (whether or not Vested) will lapse at that time. 

  
 3 

	9.3	If a Participant dies, a CSOP Option which has not Vested at the date of his death will Vest as soon as practicable thereafter in accordance with Section 9.4. 

 

	9.4	The number of Shares in respect of which a CSOP Option Vests pursuant to Section 9.3 will be determined by the Board in its discretion, taking into account: 

 

	 	9.4.1	unless the Board determines otherwise, the extent to which any Performance Condition has been satisfied at the date of death; and 

  

	 	9.4.2	unless the Board determines otherwise, the period of time that has elapsed from the start of the Performance Period to the date of death as a proportion of the Performance Period or if the CSOP Option is not subject to
a Performance Condition, the Grant Date to the date of death, 

 and to the extent that a CSOP Option does not Vest in full,
the remainder will lapse immediately. 
  

	9.5	A CSOP Option which Vests in accordance with Section 9.3 or which was already Vested at the date of death may then be exercised, subject to Rule 13, during the period of 12 months from the date of death after which
time it will lapse. 

  

	9.6	If a Participant ceases to hold office or employment with a Group Member as a result of: 

  

	 	9.6.1	redundancy (within the meaning of the Employment Rights Act 1996); 

  

	 	9.6.2	retirement; 

  

	 	9.6.3	injury or disability evidenced to the satisfaction of the Board; 

  

	 	9.6.4	the Participant’s employing company ceasing to be a Group Member or the transfer of an undertaking or part of an undertaking (in which the Participant is employed) to a person who is not a Group Member; or

  

	 	9.6.5	any other reason at the Board’s discretion, except where a Participant is summarily dismissed, 

Section 9.7 will apply, unless the Board has exercised its discretion under Section 9.6.5 in which case Section 9.8 will apply.

  

	9.7	If the Participant ceases to hold office or employment with a Group Member for a reason referred to in Sections 9.6.1 to 9.6.4: 

  

	 	9.7.1	a CSOP Option which has not Vested at the date of cessation will Vest as soon as practicable thereafter in accordance with Section 9.7.2; 

 

	 	9.7.2	the number of Shares in respect of which a CSOP Option Vests pursuant to Section 9.7.1 will be determined by the Board in its discretion, taking into account: 

 

	 	9.7.2.1	unless the Board determines otherwise, the extent to which any Performance Condition has been satisfied at the date of cessation; and 

  
 4 

	 	9.7.2.2	unless the Board determines otherwise, the period of time that has elapsed from the start of the Performance Period to the date of cessation as a proportion of the Performance Period or if the CSOP Option is not subject
to a Performance Condition, the Grant Date to the date of cessation, 

 and to the extent that a CSOP Option does not Vest in
full, the remainder will lapse immediately; and 
  

	 	9.7.3	subject to it lapsing earlier under Rule 13, a CSOP Option may be exercised during the period of 6 months from the date of cessation after which time it will lapse. 

 

	9.8	If the Participant ceases to hold office or employment with a Group Member and the Board exercises its discretion under Section 9.6.5: 

 

	 	9.8.1	a CSOP Option which has not Vested at the date of cessation will continue and, subject to it Vesting and lapsing earlier under Rule 13, will Vest in accordance with Section 9.8.2 on the Normal Vesting Date;

  

	 	9.8.2	the number of Shares in respect of which a CSOP Option Vests pursuant to Section will be determined by the Board in its discretion, taking into account: 

 

	 	9.8.2.1	unless the Board determines otherwise the extent to which any Performance Condition has been satisfied at the end of the Performance Period; and 

 

	 	9.8.2.2	unless the Board determines otherwise, the period of time that has elapsed from the start of the Performance Period to the date of cessation as a proportion of the Performance Period or if the CSOP Option is not subject
to a Performance Condition, the Grant Date to the date of cessation, 

 and to the extent that a CSOP Option does not Vest in
full, the remainder will lapse immediately; and 
  

	 	9.8.3	subject to it lapsing earlier under Rule 13, a CSOP Option may be exercised during the period of 6 months from the Normal Vesting Date after which time it will lapse. 

 

	9.9	Subject to Section 9.3, if a Participant ceases to hold office or employment with a Group Member on or after the Vesting Date as a result of resignation by the Participant from such office or employment or an event
listed in Section 9.6, a CSOP Option which has Vested prior to the date of cessation may be exercised, subject to it lapsing earlier under Rule 13, for a period of six months from the date of such cessation, after which time it will lapse.

  

	9.10	For the purposes of the Schedule, no person will be treated as ceasing to be in office or employment with a Group Member until that person no longer holds 

 

	 	9.10.1	an office or employment; or 

  

	 	9.10.2	a right to return to work, 

 with any Group Member. 

  
 5 

	10.	CORPORATE EVENTS 

  

	10.1	This Section 10.1 is supplemental to Rule 13. If in consequence of a person obtaining Control of the Company a result of an event referred to in Rule 13.3 Shares no longer meet the requirements referred to in
paragraph 15 of ITEPA Schedule 4, a CSOP Option may be exercised to the extent Vested (in accordance with Rule 13.1) no later than 20 days after the date on which Control is obtained, notwithstanding that the Shares no longer meet those
requirements. 

  

	10.2	Rules 13.8 and 13.9 shall not apply to CSOP Options and in the context of CSOP Options any reference within the Rules to “Rules 13.8 and 13.9” shall be interpreted as referring to the “Sections 10.3 and
10.4” of this Section 10. 

  

	10.3	Subject to Section 10.4, a CSOP Option will not Vest under Rule 13.1 if an agreement to release the CSOP Option in consideration of the grant of a new share option is made between the Participant and the acquiring
company (as defined in Section 10.5 below) in accordance with Section 10.6. 

  

	10.4	If there is an Internal Reorganisation, a CSOP Option will not Vest under Rule 13.1 if the acquiring company offers to grant a new share option in consideration for the release of the CSOP Option in accordance with
Section 10.6. To the extent the Participant does not agree to the release of the CSOP Option in accordance with Section 10.6, the CSOP Option will lapse one month after the date of the Internal Reorganisation. 

 

	10.5	If another company (the “acquiring company”): 

  

	 	10.5.1	obtains control of the Company as a result of making: 

  

	 	(i)	a general offer to acquire the whole of the issued ordinary share capital of the Company which is made on a condition such that, if it is met, the person making the offer will have Control of the Company; or

  

	 	(ii)	a general offer to acquire all the Shares in the Company which are of the same class as the shares which may be acquired by the exercise of CSOP Options granted under this Schedule; 

 

	 	10.5.2	obtains Control of the Company as a result of a compromise or arrangement sanctioned by the court under section 899 of the Companies Act 2006; or 

 

	 	10.5.3	becomes bound or entitled to acquire shares in the Company under sections 979 to 982 of the Companies Act 2006, 

a CSOP Option may be released in consideration of the grant to the holder of that CSOP Option of a new share option in accordance with
Section 10.6. 
  

	10.6	If a CSOP Option is to be released in consideration of the grant of a new share option in accordance with this Section 10.6: 

  

	 	10.6.1	that must be done with the agreement of the acquiring company; 

  

	 	10.6.2	the agreement must be made in the relevant period determined in accordance with paragraph 26 of ITEPA Schedule 4 and before the CSOP Option lapses in accordance with Rule 13.1 or (in the case of an Internal
Reorganisation) Section 10.4; and 

  
 6 

	 	10.6.3	any new share option granted in consideration of the release of a CSOP Option in accordance with this Section 10.6 must satisfy the requirements of paragraphs 27(2) – 27(4) (inclusive) of ITEPA Schedule 4.

  

	10.7	If a CSOP Option is exchanged for a new option in accordance with Section 10.6, the Company will remain “the scheme organiser” within the meaning of paragraph 2(2) of ITEPA Schedule 4 for the purposes of
this Schedule and no further CSOP Options may be granted after the date on which any new option is granted. 

  

	11.	ADJUSTMENTS 

  

	11.1	Rule 14 of the Plan shall be deleted and replaced by this Section 11 and in the case of CSOP Options, any reference within the Plan to Rule 14 shall be read as referring to Section 11. 

 

	11.2	The number of Shares subject to a CSOP Option and/or the Exercise Price may be varied in the event of a Variation of Share Capital provided that: 

 

	 	11.2.1	the market value of the Shares which may be acquired under the CSOP Option determined, in the case of a Share subject to a Restriction as if that Restriction did not apply, is substantially the same immediately before
and after the variation or variations; and 

  

	 	11.2.2	the aggregate Exercise Price applying to the CSOP Option is substantially the same immediately before or after the variation or variations. 

 

	12.	AMENDMENTS 

  

	12.1	No amendment to the Plan or this Schedule which would cause this Schedule to cease to meet the requirements of ITEPA Schedule 4 will have effect in relation to any CSOP Option unless and until the Board has determined
that the amendment will take effect even if it causes this Schedule to cease to meet those requirements. 

  

	13.	BOARD DISCRETION 

  

	13.1	Any discretion exercisable or action or determination to be undertaken by the Board under Section 9 or Rules 3, 8, 9 and 13 shall be exercised or undertaken by the Board fairly and reasonably. 

  
 7 

 SCHEDULE 3 

US PARTICIPANTS 
  

	1	DEFINITIONS AND INTERPRETATION 

  

	1.1	The purpose of this Schedule 3 is to ensure that Options granted to and held by US Participants have an Exercise Price that is at least Fair Market Value, and that Conditional Awards granted to and held by US
Participants meet the requirements of the short term deferral exemption to s409A of the United States Internal Revenue Code. The terms of such Awards should be interpreted in a manner consistent with these requirements. 

 

	1.2	The Rules will apply to Awards held by Participants, who are or who may become US Participants, except as set out in this Schedule 3. Where there is any conflict between the Rules and this Schedule 3, the terms of this
Schedule 3 will prevail. 

  

	1.3	In this Schedule 3, references to “Rules” are to the rules of the Plan and references to “Paragraphs” are to paragraphs of this Schedule 3. Words and phrases shall have the same meaning as in the
Rules, except that the following amendments and additions will be made to words and expressions in the Rules. 

  

			
	 “ADS”
	  	means an American Depositary Share being an authorised depositary security denominated in US dollars and listed on NASDAQ which represents a number of Shares and which may be evidenced by an American Depositary Receipt;
		
	 “Fair Market Value”
	  	an amount equal to the fair market value (as determined in accordance with U.S. Treasury Regulation Section 1.409A-1(b)(5)(iv)(A)) of a Share;
		
	 “Share”
	  	means a fully paid ordinary share in the capital of the Company and, unless the context otherwise requires, includes ADSs; and
		
	 “US Participant”
	  	means a Participant who is a:
		
		  	 (a)    US citizen;

		
		  	 (b)    US permanent resident (evidenced by a green-card);

		
		  	 (c)    non-US citizen who is posted to the United States on or after the Grant
Date and who is (or is expected to become) subject to US taxation as a resident alien; or

		
		  	 (d)    non-US citizen to the extent that he or she is or becomes subject to
Section 409A of the Internal Revenue Code 1986, as amended, with regard to an Award including a non-resident alien taxpayer, with respect to some portion of an Award that is deemed to be income from a US source.

  

	2	OPTIONS 

  

	2.1	The following new Rule 2.6 will be added to Rule 2: 

 “The Exercise Price of an Option
granted to a US Participant must not be less than the Fair Market Value of a Share at the Grant Date.” 

  
 1 

	2.2	The following new Rule 2.7 will be added to Rule 2: 

 “If a Participant becomes a US
Participant after the Grant Date, any unvested Options subject to an Exercise Price that is less than the Fair Market Value on the Grant Date, and any unvested Cash Options that he holds at that time will be converted (without any further action on
the part of the US Participant or the Company) into Conditional Awards or Cash Conditional Awards respectively, unless the Company determines otherwise, either at the Grant Date or subsequently.” 

 

	3	DIVIDEND EQUIVALENTS 

  

	3.1	The following wording will be added to Rule 5.2 after the words “of the relevant Award”: 

“In any event, in the case of a Conditional Award, this should be no later than 31 December of the year in which the Award
Vests.” 
  

	4	VESTING AND EXERCISE 

  

	4.1	The following wording will be added to Rule 9.6 after the words “as soon as reasonably practicable thereafter”: 

“In any event, in the case of a Conditional Award, this should be no later than 31 December of the year in which the Award
Vests.” 
  

	5	CASH EQUIVALENT 

  

	5.1	The following wording will be added Rule 11.2.3 after the words “as soon as reasonably practicable after Vest”: 

“In any event, in the case of a Conditional Award, this should be no later than 31 December of the year in which the Award
Vests.” 
  

	6	CESSATION OF EMPLOYMENT – CONDITIONAL AWARDS 

 The provisions of Rule 12 shall
apply to Options held by US Participants. The following shall apply to Conditional Awards held by US Participants: 
  

	6.1	The following wording in Rule 12.1 will be deleted “unless the Board determines otherwise”. 

  

	6.2	If an Award is not subject to a Performance Condition, Rules 12.5 to 12.8 will not apply and will be replaced with the following: 

  

	 	12.5	“If a Participant ceases to hold office or employment with a Group Member as a result of: 

  

	 	12.5.1	ill-health, injury or disability as established to the satisfaction of the Board; 

  

	 	12.5.2	redundancy; 

  

	 	12.5.3	the Participant’s employing company ceasing to be a Group Member or the transfer of an undertaking or part of an undertaking (in which the Participant is employed) to a person who is not a Group Member; or

  

	 	12.5.4	any other reason at the Board’s discretion, except where a Participant is summarily dismissed, 

his Award will Vest as soon as practicable following the date of cessation. 

	 	

  
 2 

	 	12.6	The number of Shares in respect of which an Award Vests pursuant to Rule 12.5 will be determined by the Board in its discretion, taking into account unless the Board determines otherwise, the period of time that has
elapsed from the Grant Date to the date of cessation of office or employment, and to the extent that an Award does not Vest in full, the remainder will lapse immediately.” 

 

	7	AMENDMENTS 

  

	7.1	The following Rule 15.4 will be added to Rule 15: 

 “Notwithstanding the provisions of this
Rule 15, any such amendment will only be effective to the extent that it complies with s.409A of the US Internal Revenue Code of 1986 as amended from time to time.” 
  

	8	CASH AWARDS 

  

	8.1	The following wording will be added to paragraph 1.3 of Schedule 1, after the words “as may be required by law”: 

“In any event, in the case of a Cash Conditional Award, this should be no later than 31 December of the year in which the Award
Vests.” 

  
 3EX-4.4

 Exhibit 4.4 
  

SUMMIT THERAPEUTICS PLC 

and 
  

 
 Trustee 

INDENTURE 
 Dated as of
_______________ 
 SENIOR DEBT SECURITIES 

 CROSS-REFERENCE TABLE(1) 

 

			
	 Section of
 Trust Indenture
Act
 of 1939, as amended
	  	 Section
of
Indenture        

	 310(a)
	  	6.09
	 310(b)
	  	6.08
		  	6.10
	 310(c)
	  	Inapplicable
	 311(a)
	  	6.13
	 311(b)
	  	6.13
	 311(c)
	  	Inapplicable
	 312(a)
	  	4.01 4.04
	 312(b)
	  	4.04(c)
	 312(c)
	  	4.04(c)
	 313(a)
	  	4.03
	 313(b)
	  	4.03
	 313(c)
	  	4.03
	 313(d)
	  	4.03
	 314(a)
	  	4.02
	 314(b)
	  	Inapplicable
	 314(c)
	  	2.04
		  	8.04
		  	9.01(c)
		  	10.01(b)
		  	11.05
	 314(d)
	  	Inapplicable
	 314(e)
	  	11.05
	 314(f)
	  	Inapplicable
	 315(a)
	  	 6.01
 6.02

	 315(b)
	  	5.11
	 315(c)
	  	6.01
	 315(d)
	  	6.01
		  	6.02
	 315(e)
	  	5.12
	 316(a)
	  	 5.09
 5.10

		  	7.04
	 316(b)
	  	 5.06
 5.10

	 316(c)
	  	7.02
	 317(a)
	  	5.04
	 317(b)
	  	3.04
	 318(a)
	  	11.07

  

	(1)	This Cross-Reference Table does not constitute part of the Indenture and shall not have any bearing on the interpretation of any of its terms or provisions. 

 TABLE OF CONTENTS 

 
  

							
	 	  	PAGE	 
	 ARTICLE 1     DEFINITIONS
	  	 	1	  
	 Section 1.01
	  	Certain Terms Defined	  	 	1	  
		
	 ARTICLE 2     SECURITIES
	  	 	5	  
	 Section 2.01
	  	Forms Generally	  	 	5	  
	 Section 2.02
	  	Form of Trustee’s Certificate of Authentication	  	 	6	  
	 Section 2.03
	  	Amount Unlimited; Issuable in Series	  	 	6	  
	 Section 2.04
	  	Authentication and Delivery of Securities	  	 	8	  
	 Section 2.05
	  	Execution of Securities	  	 	10	  
	 Section 2.06
	  	Certificate of Authentication	  	 	10	  
	 Section 2.07
	  	Denomination and Date of Securities; Payments of Interest	  	 	10	  
	 Section 2.08
	  	Registration, Transfer and Exchange	  	 	11	  
	 Section 2.09
	  	Mutilated, Defaced, Destroyed, Lost and Stolen Securities	  	 	13	  
	 Section 2.10
	  	Cancellation of Securities; Destruction Thereof	  	 	14	  
	 Section 2.11
	  	Temporary Securities	  	 	14	  
		
	 ARTICLE 3     COVENANTS OF THE ISSUER
	  	 	15	  
	 Section 3.01
	  	Payment of Principal and Interest	  	 	15	  
	 Section 3.02
	  	Offices for Payments, Etc	  	 	15	  
	 Section 3.03
	  	Appointment to Fill a Vacancy in Office of Trustee	  	 	16	  
	 Section 3.04
	  	Paying Agents	  	 	16	  
	 Section 3.05
	  	Written Statement to Trustee	  	 	16	  
		
	 ARTICLE 4     SECURITYHOLDERS LISTS AND REPORTS BY
THE ISSUER AND THE TRUSTEE
	  	 	17	  
	 Section 4.01
	  	Issuer to Furnish Trustee Information as to Names and Addresses of Securityholders	  	 	17	  
	 Section 4.02
	  	Reports by the Issuer	  	 	17	  
	 Section 4.03
	  	Reports by the Trustee	  	 	17	  
	 Section 4.04
	  	Preservation of Information; Communication with Securityholders	  	 	17	  
		
	 ARTICLE 5     REMEDIES OF THE TRUSTEE AND
SECURITYHOLDERS ON EVENT OF DEFAULT
	  	 	18	  
	 Section 5.01
	  	Event of Default Defined; Acceleration of Maturity; Waiver of Default	  	 	18	  
	 Section 5.02
	  	Collection of Debt by Trustee; Trustee May Prove Debt	  	 	20	  
	 Section 5.03
	  	Application of Proceeds	  	 	22	  
	 Section 5.04
	  	Suits for Enforcement	  	 	22	  
	 Section 5.05
	  	Restoration of Rights on Abandonment of Proceedings	  	 	23	  
	 Section 5.06
	  	Limitations on Suits by Securityholders	  	 	23	  
	 Section 5.07
	  	Unconditional Right of Securityholders to Institute Certain Suits	  	 	23	  

  
 i 

							
	 Section 5.08
	  	Powers and Remedies Cumulative; Delay or Omission Not Waiver of Default	  	 	24	  
	 Section 5.09
	  	Control by Holders of Securities	  	 	24	  
	 Section 5.10
	  	Waiver of Past Defaults	  	 	25	  
	 Section 5.11
	  	Trustee to Give Notice of Default	  	 	25	  
	 Section 5.12
	  	Right of Court to Require Filing of Undertaking to Pay Costs	  	 	25	  
		
	 ARTICLE 6     CONCERNING THE TRUSTEE
	  	 	26	  
	 Section 6.01
	  	Duties and Responsibilities of the Trustee; During Default; Prior to Default	  	 	26	  
	 Section 6.02
	  	Certain Rights of the Trustee	  	 	26	  
	 Section 6.03
	  	Trustee Not Responsible for Recitals, Disposition of Securities or Application of Proceeds Thereof	  	 	27	  
	 Section 6.04
	  	Trustee and Agents May Hold Securities; Collections, Etc	  	 	28	  
	 Section 6.05
	  	Moneys Held by Trustee	  	 	28	  
	 Section 6.06
	  	Compensation and Indemnification of Trustee and Its Prior Claim	  	 	28	  
	 Section 6.07
	  	Right of Trustee to Rely on Officer’s Certificate, Etc	  	 	28	  
	 Section 6.08
	  	Disqualification; Conflicting Interests	  	 	29	  
	 Section 6.09
	  	Persons Eligible for Appointment as Trustee	  	 	29	  
	 Section 6.10
	  	Resignation and Removal; Appointment of Successor Trustee	  	 	29	  
	 Section 6.11
	  	Acceptance of Appointment by Successor Trustee	  	 	30	  
	 Section 6.12
	  	Merger, Conversion, Consolidation or Succession to Business of Trustee	  	 	31	  
	 Section 6.13
	  	Preferential Collection of Claims Against the Issuer	  	 	32	  
		
	 ARTICLE 7     CONCERNING THE SECURITYHOLDERS
	  	 	32	  
	 Section 7.01
	  	Evidence of Action Taken by Securityholders	  	 	32	  
	 Section 7.02
	  	Proof of Execution of Instruments and of Holding of Securities	  	 	32	  
	 Section 7.03
	  	Holders to Be Treated as Owners	  	 	32	  
	 Section 7.04
	  	Securities Owned by Issuer Deemed Not Outstanding	  	 	33	  
	 Section 7.05
	  	Right of Revocation of Action Taken	  	 	33	  
		
	 ARTICLE 8     SUPPLEMENTAL INDENTURES
	  	 	33	  
	 Section 8.01
	  	Supplemental Indentures Without Consent of Securityholders	  	 	33	  
	 Section 8.02
	  	Supplemental Indentures With Consent of Securityholders	  	 	35	  
	 Section 8.03
	  	Effect of Supplemental Indenture	  	 	36	  
	 Section 8.04
	  	Documents to Be Given to Trustee	  	 	36	  
	 Section 8.05
	  	Notation on Securities in Respect of Supplemental Indentures	  	 	37	  
		
	 ARTICLE 9     CONSOLIDATION, MERGER, SALE OR
CONVEYANCE
	  	 	37	  
	 Section 9.01
	  	Issuer May Consolidate, Etc., on Certain Terms	  	 	37	  
	 Section 9.02
	  	Successor Issuer Substituted	  	 	38	  
		
	 ARTICLE 10   SATISFACTION AND DISCHARGE OF INDENTURE;
DEFEASANCE; UNCLAIMED MONEYS
	  	 	38	  
	 Section 10.01
	  	Satisfaction and Discharge of Indenture; Defeasance	  	 	38	  

  
 ii 

							
	 Section 10.02
	  	Application by Trustee of Funds Deposited for Payment of Securities	  	 	42	  
	 Section 10.03
	  	Repayment of Moneys Held by Paying Agent	  	 	42	  
	 Section 10.04
	  	Return of Moneys Held by Trustee and Paying Agent Unclaimed for Two Years	  	 	42	  
	 Section 10.05
	  	Indemnity for U.S. Government Obligations	  	 	42	  
		
	 ARTICLE 11   MISCELLANEOUS PROVISIONS
	  	 	42	  
	 Section 11.01
	  	No Recourse	  	 	42	  
	 Section 11.02
	  	Provisions of Indenture for the Sole Benefit of Parties and Holders of Securities	  	 	43	  
	 Section 11.03
	  	Successors and Assigns of Issuer Bound by Indenture	  	 	43	  
	 Section 11.04
	  	Notices and Demands on Issuer, Trustee and Holders of Securities	  	 	43	  
	 Section 11.05
	  	Officer’s Certificates and Opinions of Counsel; Statements to Be Contained Therein	  	 	44	  
	 Section 11.06
	  	Payments Due on Saturdays, Sundays and Holidays	  	 	45	  
	 Section 11.07
	  	Conflict of Any Provision of Indenture With Trust Indenture Act of 1939	  	 	45	  
	 Section 11.08
	  	New York Law to Govern	  	 	45	  
	 Section 11.09
	  	Counterparts	  	 	45	  
	 Section 11.10
	  	Effect of Headings	  	 	45	  
	 Section 11.11
	  	Actions by Successor	  	 	45	  
	 Section 11.12
	  	Severability	  	 	45	  
		
	 ARTICLE 12   REDEMPTION OF SECURITIES AND SINKING
FUNDS
	  	 	45	  
	 Section 12.01
	  	Applicability of Article	  	 	45	  
	 Section 12.02
	  	Notice of Redemption; Partial Redemptions	  	 	46	  
	 Section 12.03
	  	Payment of Securities Called for Redemption	  	 	47	  
	 Section 12.04
	  	Exclusion of Certain Securities from Eligibility for Selection for Redemption	  	 	48	  
	 Section 12.05
	  	Mandatory and Optional Sinking Funds	  	 	48	  

  
 iii 

 THIS INDENTURE, dated as of
             between Summit Therapeutics plc, a public limited company incorporated in England and Wales (the “Issuer”), and
            , a              (the “Trustee”), 

W I T N E S S E T H : 

WHEREAS, the Issuer may from time to time duly authorize the issue of its unsecured debentures, notes or other evidences of
indebtedness to be issued in one or more series (the “Securities”) up to such principal amount or amounts as may from time to time be authorized in accordance with the terms of this Indenture; 

WHEREAS, the Issuer has duly authorized the execution and delivery of this Indenture to provide, among other things, for the authentication,
delivery and administration of the Securities; and 
 WHEREAS, all things necessary to make this Indenture a valid indenture and agreement
according to its terms have been done; 
 NOW, THEREFORE: 

In consideration of the premises and the purchases of the Securities by the holders thereof, the Issuer and the Trustee mutually covenant and
agree for the equal and proportionate benefit of the respective holders from time to time of the Securities as follows: 
 ARTICLE 1 

DEFINITIONS 

Section 1.01 Certain Terms Defined. The following terms (except as otherwise expressly provided or unless the context
otherwise clearly requires) for all purposes of this Indenture and of any indenture supplemental hereto shall have the respective meanings specified in this Section. All other terms used in this Indenture that are defined in the Trust Indenture Act
of 1939 or the definitions of which in the Securities Act of 1933 are referred to in the Trust Indenture Act of 1939, including terms defined therein by reference to the Securities Act of 1933 (except as herein otherwise expressly provided or unless
the context otherwise clearly requires), shall have the meanings assigned to such terms in said Trust Indenture Act and in said Securities Act as in force at the date of this Indenture. All accounting terms used herein and not expressly defined
shall have the meanings assigned to such terms in accordance with the International Financial Reporting Standards as issued by the International Accounting Standards Board at the time of any computation. The words “herein”,
“hereof” and “hereunder” and other words of similar import refer to this Indenture as a whole and not to any particular Article, Section or other subdivision. The terms defined in this Article have the meanings assigned to them
in this Article and include the plural as well as the singular. 
 “Board of Directors” means either the
Board of Directors of the Issuer or any committee of such Board duly authorized to act on its behalf. 

  
 1 

 “Board Resolution” means a copy of one or more resolutions, certified by
the secretary or an assistant secretary of the Issuer to have been duly adopted by the Board of Directors and to be in full force and effect, and delivered to the Trustee. 

“Business Day” means, with respect to any Security, a day that in the city (or in any of the cities, if more than one)
in which amounts are payable, as specified in the form of such Security, is not a day on which banking institutions are authorized or required by law or regulation to close. 

“Commission” means the Securities and Exchange Commission, as from time to time constituted, created under the
Securities Exchange Act of 1934, or if at any time after the execution and delivery of this Indenture such Commission is not existing and performing the duties now assigned to it under the Trust Indenture Act of 1939, then the body performing such
duties on such date. 
 “Corporate Trust Office” means the office of the Trustee at which the corporate trust
business of the Trustee shall, at any particular time, be principally administered, which office is, at the date as of which this Indenture is dated, located at             .

 “Debt” of any Person means any debt for money borrowed which is created, assumed, incurred or guaranteed in
any manner by such Person or for which such Person is otherwise responsible or liable, and shall expressly include any such guaranty thereof by such Person. For the purpose of computing the amount of the Debt of any Person there shall be excluded
all Debt of such Person for the payment or redemption or satisfaction of which money or securities (or evidences of such Debt, if permitted under the terms of the instrument creating such Debt) in the necessary amount shall have been deposited in
trust with the proper depositary, whether upon or prior to the maturity or the date fixed for redemption of such Debt; and, in any instance where Debt is so excluded, for the purpose of computing the assets of such Person there shall be excluded the
money, securities or evidences of Debt deposited by such Person in trust for the purpose of paying or satisfying such Debt. 

“Depositary” means, with respect to the Securities of any series issuable or issued in the form of one or more Global
Securities, the Person designated as Depositary by the Issuer pursuant to Section 2.04 until a successor Depositary shall have become such pursuant to the applicable provisions of this Indenture, and thereafter “Depositary”
shall mean or include each Person who is then a Depositary hereunder, and if at any time there is more than one such Person, “Depositary” as used with respect to the Securities of any such series shall mean the Depositary with
respect to the Global Securities of that series. 
 “Dollar” means the currency of the United States of
America as at the time of payment is legal tender for the payment of public and private debts. 
 “Event of
Default” means any event or condition specified as such in Section 5.01. 
 “Foreign Currency” means
a currency issued by the government of a country other than the United States. 

  
 2 

 “Global Security” means a Security evidencing all or a part of a series
of Securities, issued to the Depositary for such series in accordance with Section 2.04, and bearing the legend prescribed in Section 2.04. 

“Holder”, “holder”, “holder of Securities”, “Securityholder” or
other similar terms mean the Person in whose name such Security is registered in the Security register kept by the Issuer for that purpose in accordance with the terms hereof. 

“Indenture” means this instrument as originally executed and delivered or, if amended or supplemented as herein
provided, as so amended or supplemented or both, and shall include the forms and terms of particular series of Securities established as contemplated hereunder. 

“interest”, unless the context otherwise requires, refers to interest, and when used with respect to non-interest
bearing Securities, refers to interest payable after maturity, if any. 
 “Issuer” means Summit Therapeutics
plc, a public limited company incorporated in England and Wales, and, subject to Article 9, its successors and assigns. 

“Issuer Order” means a written statement, request or order of the Issuer signed in its name by the chairman of the
Board of Directors, the president or any vice president of the Issuer. 
 “Notice of Default” shall have the meaning
set forth in Section 5.01(c). 
 “Officer’s Certificate” means a certificate signed by the chairman of
the Board of Directors, the president, any vice president, the treasurer, the secretary or any assistant secretary of the Issuer and delivered to the Trustee. Each such certificate shall comply with Section 314 of the Trust Indenture Act of
1939 and, except to the extent provided herein, shall include the statements provided for in Section 11.05. 

“Opinion of Counsel” means an opinion in writing signed by the general corporate counsel or such other legal counsel
who may be an employee of or counsel to the Issuer and who shall be satisfactory to the Trustee. Each such opinion shall comply with Section 314 of the Trust Indenture Act of 1939 and shall include the statements provided for in
Section 11.05, if and to the extent required hereby. 
 “Ordinary Shares” means ordinary shares, par
value £0.01 per share, of the Issuer as the same exists at the date of execution and delivery of this Indenture or as such shares may be reconstituted from time to time or when represented by American Depositary Shares issued in respect
thereof. 
 “original issue date” of any Security (or portion thereof) means the earlier of (a) the date
of such Security or (b) the date of any Security (or portion thereof) for which such Security was issued (directly or indirectly) on registration of transfer, exchange or substitution. 

“Original Issue Discount Security” means any Security that provides for an amount less than the principal amount
thereof to be due and payable upon a declaration of acceleration of the maturity thereof pursuant to Section 5.01. 

  
 3 

 “Outstanding”, when used with reference to Securities, shall, subject to
the provisions of Section 7.04, mean, as of any particular time, all Securities authenticated and delivered by the Trustee under this Indenture, except 

(a) Securities theretofore cancelled by the Trustee or delivered to the Trustee for cancellation; 

(b) Securities, or portions thereof, for the payment or redemption of which cash or U.S. Government Obligations (as provided
for in Section 10.01 (a) and Section 10.01(b)) in the necessary amount shall have been deposited in trust with the Trustee or with any paying agent (other than the Issuer) or shall have been set aside, segregated and held in trust by
the Issuer for the Holders of such Securities (if the Issuer shall act as its own paying agent); provided, that if such Securities, or portions thereof, are to be redeemed prior to the maturity thereof, notice of such redemption shall have
been given as herein provided, or provision satisfactory to the Trustee shall have been made for giving such notice; and 

(c) Securities in substitution for which other Securities shall have been authenticated and delivered, or which shall have
been paid, pursuant to the terms of Section 2.09 (except with respect to any such Security as to which proof satisfactory to the Trustee is presented that such Security is held by a Person in whose hands such Security is a legal, valid and
binding obligation of the Issuer), Securities converted into Ordinary Shares pursuant hereto and Securities not deemed outstanding pursuant to Section 12.02. 

In determining whether the Holders of the requisite principal amount of Outstanding Securities of any or all series have given any request,
demand, authorization, direction, notice, consent or waiver hereunder, the principal amount of an Original Issue Discount Security that shall be deemed to be Outstanding for such purposes shall be the amount of the principal thereof that would be
due and payable as of the date of such determination upon a declaration of acceleration of the maturity thereof pursuant to Section 5.01. 

“Person” means any individual, corporation, partnership, limited partnership, limited liability company, limited
company, joint venture, association, joint stock company, trust, unincorporated organization or government or any agency or political subdivision thereof. 

“principal” whenever used with reference to the Securities or any Security or any portion thereof, shall be deemed to
include “and premium, if any”. 
 “record date” shall have the meaning set forth in Section 2.07. 

“Responsible Officer”, when used with respect to the Trustee, means the chairman of the board of directors, any vice
chairman of the board of directors, the chairman of the trust committee, the chairman of the executive committee, any vice chairman of the executive committee, the president, any vice president, the cashier, the secretary, the treasurer, any trust
officer, any assistant trust officer, any assistant vice president, any assistant cashier, any assistant secretary, any assistant treasurer, or any other officer or assistant officer of the Trustee customarily performing functions similar to those
performed by the persons who at the time shall be such officers, respectively, or to whom any corporate trust matter is referred because of his or her knowledge of and familiarity with the particular subject. 

  
 4 

 “Security” or “Securities” has the meaning stated in the
first recital of this Indenture, or, as the case may be, Securities that have been authenticated and delivered under this Indenture. 

“Security Registrar” shall have the meaning set forth in Section 4.01(b). 

“Subsidiary” means a Person of which a majority of the total outstanding voting power under ordinary circumstances is
owned, directly or indirectly, by the Issuer or by one or more subsidiaries of the Issuer, or by the Issuer and one or more subsidiaries of the Issuer. 

“Trust Indenture Act of 1939” (except as otherwise provided in Sections 8.01 and 8.02) means the Trust Indenture Act
of 1939 as in force at the date as of which this Indenture was originally executed. 
 “Trustee” means the
Person identified as “Trustee” in the first paragraph hereof and, subject to the provisions of Article 6, shall also include any successor trustee. “Trustee” shall also mean or include each Person who is then a
trustee hereunder and if at any time there is more than one such Person, “Trustee” as used with respect to the Securities of any series shall mean the trustee with respect to the Securities of such series. 

“U.S. Government Obligation” means (a) a direct obligation of the United States of America, backed by its full
faith and credit, or (b) an obligation of a Person controlled or supervised by and acting as an agency or instrumentality of the United States of America, the payment of which is unconditionally guaranteed as a full faith and credit obligation
by the United States of America. 
 “vice president”, when used with respect to the Issuer or the Trustee,
means any vice president, whether or not designated by a number or a word or words added before or after the title of “vice president”. 

“Yield to Maturity” means the yield to maturity on a series of securities, calculated at the time of issuance of such
series, or, if applicable, at the most recent redetermination of interest on such series, and calculated in accordance with accepted financial practice. 

ARTICLE 2 
 SECURITIES 

Section 2.01 Forms Generally. The Securities of each series shall be substantially in such form (not inconsistent with this
Indenture) as shall be established by or pursuant to one or more Board Resolutions (as set forth in a Board Resolution or, to the extent established pursuant to (rather than set forth in) a Board Resolution, an Officer’s Certificate detailing
such establishment) or in one or more indentures supplemental hereto, in each case with such appropriate insertions, omissions, substitutions and other variations as are required or permitted by this Indenture and may have imprinted or otherwise
reproduced thereon such legend or legends or endorsements, not inconsistent with the provisions of this Indenture, as may be required to comply with any law or with any rules or regulations pursuant thereto, or with any rules of any securities
exchange or to conform to general usage, all as may be determined by the officers executing such Securities as evidenced by their execution of such Securities. 

  
 5 

 The definitive Securities shall be printed, lithographed or engraved on steel engraved borders or
may be produced in any other manner, all as determined by the officers executing such Securities as evidenced by their execution of such Securities. 

Section 2.02 Form of Trustee’s Certificate of Authentication. The Trustee’s certificate of authentication on all
Securities shall be in substantially the following form: 
 This is one of the Securities of the series designated herein and
referred to in the within-mentioned Indenture. 
  

			
	as Trustee
		
	By:	 	 
		 	Authorized Officer

 Section 2.03 Amount Unlimited; Issuable in Series. The aggregate principal
amount of Securities which may be authenticated and delivered under this Indenture is, subject at all times to compliance by the Issuer with any requirements under its articles of association, unlimited. 

The Securities may be issued in one or more series. The terms of a series of Securities shall be established prior to the initial issuance
thereof in or pursuant to one or more Board Resolutions, or, to the extent established pursuant to (rather than set forth in) a Board Resolution, in an Officer’s Certificate detailing such establishment and/or established in one or more
indentures supplemental hereto. The terms of such series reflected in such Board Resolution, Officer’s Certificate, or supplemental indenture may include the following or any additional or different terms: 

(a) the designation of the Securities of the series (which may be part of a series of Securities previously issued); 

(b) the terms and conditions, if applicable, upon which conversion or exchange of the Securities into Ordinary Shares will be
effected, including the initial conversion or exchange price or rate and any adjustments thereto, the conversion or exchange period and other provisions in addition to or in lieu of those described herein; 

(c) any limit upon the aggregate principal amount of the Securities of the series that may be authenticated and delivered
under this Indenture (except for Securities authenticated and delivered upon registration of transfer of, or in exchange for, or in lieu of, other Securities of the series pursuant to Section 2.08, 2.09, 2.11, 8.05 or 12.03); 

  
 6 

 (d) if other than Dollars, the Foreign Currency in which the Securities of that
series are denominated; 
 (e) any date on which the principal of the Securities of the series is payable and the right, if
any, to extend such date or dates; 
 (f) the rate or rates at which the Securities of the series shall bear interest, if
any, the record date or dates for the determination of holders to whom interest is payable, the date or dates from which such interest shall accrue and on which such interest shall be payable and/or the method by which such rate or rates or date or
dates shall be determined, and the right, if any, to extend the interest payment periods and the duration of that extension; 

(g) the place or places where the principal of and any interest on Securities of the series shall be payable (if other than as
provided in Section 3.02); 
 (h) the price or prices at which, the period or periods within which and the terms and
conditions upon which Securities of the series may be redeemed, in whole or in part, at the option of the Issuer, pursuant to any sinking fund or otherwise; 

(i) the obligation, if any, of the Issuer to redeem, purchase or repay Securities of the series pursuant to any mandatory
redemption, sinking fund or analogous provisions or at the option of a Holder thereof and the price or prices at which and the period or periods within which and any terms and conditions upon which Securities of the series shall be redeemed,
purchased or repaid, in whole or in part, pursuant to such obligation; 
 (j) if other than denominations of $1,000 and any
integral multiple thereof, the denominations in which Securities of the series shall be issuable; 
 (k) if other than the
principal amount thereof, the portion of the principal amount of Securities of the series which shall be payable upon declaration of acceleration of the maturity thereof; 

(l) if other than the currency in which the Securities of that series are denominated, the currency in which payment of the
principal of or interest on the Securities of such series shall be payable; 
 (m) if the principal of or interest on the
Securities of the series is to be payable, at the election of the Issuer or a Holder thereof, in a currency other than that in which the Securities are denominated, the period or periods within which, and the terms and conditions upon which, such
election may be made; 
 (n) if the amount of payments of principal of and interest on the Securities of the series may be
determined with reference to an index based on a currency other than that in which the Securities of the series are denominated, or by reference to one or more currency exchange rates, securities or baskets of securities, commodity prices or
indices, the manner in which such amounts shall be determined; 

  
 7 

 (o) if Sections 10.01(b) or 10.01(c) are inapplicable to Securities of such
series; 
 (p) whether and under what circumstances the Issuer will pay additional amounts on the Securities of any series
in respect of any tax, assessment or governmental charge withheld or deducted and, if so, whether the Issuer will have the option to redeem such Securities rather than pay such additional amounts; 

(q) if the Securities of such series are to be issuable in definitive form (whether upon original issue or upon exchange of a
temporary Security of such series) only upon receipt of certain certificates or other documents or satisfaction of other conditions, then the form and terms of such certificates, documents or conditions; 

(r) any trustees, authenticating or paying agents, transfer agents or registrars or any other agents with respect to the
Securities of such series; 
 (s) any other events of default or covenants with respect to the Securities of such series in
addition to or in lieu of those contained in this Indenture; 
 (t) if the Securities of the series may be issued in
exchange for surrendered Securities of another series, or for other securities of the Issuer, pursuant to the terms of such Securities or securities or of any agreement entered into by the Issuer, the ratio of the principal amount of the Securities
of the series to be issued to the principal amount of the Securities or securities to be surrendered in exchange, and any other material terms of the exchange; and 

(u) any other terms of the series. 

The Issuer may from time to time, without notice to or the consent of the holders of any series of Securities, create and issue further
Securities of any such series ranking equally with the Securities of such series in all respects (or in all respects other than (1) the payment of interest accruing prior to the issue date of such further Securities or (2) the first
payment of interest following the issue date of such further Securities). Such further Securities may be consolidated and form a single series with the Securities of such series and have the same terms as to status, redemption or otherwise as the
Securities of such series. 
 Section 2.04 Authentication and Delivery of Securities. The Issuer may deliver Securities
of any series executed by the Issuer to the Trustee for authentication together with the applicable documents referred to below in this Section, and the Trustee shall thereupon authenticate and deliver such Securities to or upon the order of the
Issuer (contained in the Issuer Order referred to below in this Section) or pursuant to such procedures acceptable to the Trustee and to such recipients as may be specified from time to time by an Issuer Order. The maturity date, original issue
date, interest rate and any other terms of the Securities of such series shall be determined by or pursuant to such Issuer Order and procedures. If provided for in such procedures, such Issuer Order may authorize authentication and delivery pursuant
to oral instructions from the Issuer or its duly authorized agent, which instructions shall be promptly confirmed in writing. In authenticating such Securities and accepting the additional responsibilities under this Indenture in relation to such
Securities, the Trustee shall be entitled to receive, and (subject to Section 6.01) shall be fully protected in relying upon: 

  
 8 

 (a) an Issuer Order requesting such authentication and setting forth delivery
instructions if the Securities are not to be delivered to the Issuer; 
 (b) any Board Resolution, Officer’s
Certificate and/or executed supplemental indenture referred to in Sections 2.01 and 2.03 by or pursuant to which the forms and terms of the Securities were established; 

(c) an Officer’s Certificate setting forth the form or forms and terms of the Securities stating that the form or forms
and terms of the Securities have been established pursuant to Sections 2.01 and 2.03 and comply with this Indenture, and covering such other matters as the Trustee may reasonably request; and 

(d) an Opinion of Counsel to the effect that: 

(i) the form or forms and terms of such Securities have been established pursuant to Sections 2.01 and 2.03 and comply with
this Indenture, 
 (ii) the authentication and delivery of such Securities by the Trustee are authorized under the
provisions of this Indenture, 
 (iii) such Securities when authenticated and delivered by the Trustee and issued by the
Issuer in the manner and subject to any conditions specified in such Opinion of Counsel, will constitute valid and binding obligations of the Issuer, and 

(iv) all laws and requirements in respect of the execution and delivery by the Issuer of the Securities have been complied
with, 
 and covering such other matters as the Trustee may reasonably request. 

The Trustee shall have the right to decline to authenticate and deliver any Securities under this Section if the Trustee, being advised by
counsel, determines that such action may not lawfully be taken by the Issuer or if the Trustee in good faith by its board of directors or board of trustees, executive committee, or a trust committee of directors or trustees or Responsible Officers
shall determine that such action would expose the Trustee to personal liability to existing Holders or would affect the Trustee’s own rights, duties or immunities under the Securities, this Indenture or otherwise. 

The Issuer shall execute and the Trustee shall, in accordance with this Section with respect to the Securities of a series, authenticate and
deliver one or more Global Securities that (i) shall represent and shall be denominated in an amount equal to the aggregate principal amount of all of the Securities of such series issued and not yet cancelled, (ii) shall be registered in
the name of the Depositary for such Global Security or Securities or the nominee of such Depositary, (iii) shall be delivered by the Trustee to such Depositary or pursuant to such Depositary’s instructions and (iv) shall bear a legend
substantially to the following effect: “Unless and until it is exchanged in whole or in part for Securities in definitive registered form, this Security may not be transferred except as a whole by the Depositary to the nominee of the Depositary
or by a nominee of the Depositary to the Depositary or another nominee of the Depositary or by the Depositary or any such nominee to a successor Depositary or a nominee of such successor Depositary.” 

  
 9 

 Each Depositary designated pursuant to this Section must, at the time of its designation and at
all times while it serves as Depositary, be a clearing agency registered under the Securities Exchange Act of 1934 and any other applicable statute or regulation. 

Section 2.05 Execution of Securities. Any officer duly authorized by the Board of Directors shall be permitted to sign the
Securities on behalf of the Issuer. Such signatures may be the manual or facsimile signatures of the present or any future such officers. Typographical and other minor errors or defects in any such reproduction of any such signature shall not affect
the validity or enforceability of any Security that has been duly authenticated and delivered by the Trustee. 
 In case any officer of the
Issuer who shall have signed any of the Securities shall cease to be such officer before the Security so signed shall be authenticated and delivered by the Trustee or disposed of by the Issuer, such Security nevertheless may be authenticated and
delivered or disposed of as though the person who signed such Security had not ceased to be such officer of the Issuer; and any Security may be signed on behalf of the Issuer by such persons as, at the actual date of the execution of such Security,
shall be the proper officers of the Issuer, although at the date of the execution and delivery of this Indenture any such person was not such an officer. 

Section 2.06 Certificate of Authentication. Only such Securities as shall bear thereon a certificate of authentication
substantially in the form hereinbefore recited, executed by the Trustee by the manual signature of one of its authorized officers, shall be entitled to the benefits of this Indenture or be valid or obligatory for any purpose. The execution of such
certificate by the Trustee upon any Security executed by the Issuer shall be conclusive evidence that the Security so authenticated has been duly authenticated and delivered hereunder and that the Holder is entitled to the benefits of this
Indenture. 
 Section 2.07 Denomination and Date of Securities; Payments of Interest. The Securities of each series shall be
issuable in denominations established as contemplated by Section 2.03 or, if not so established, in denominations of $1,000 and any integral multiple thereof. The Securities of each series shall be numbered, lettered or otherwise distinguished
in such manner or in accordance with such plan as the officers of the Issuer executing the same may determine with the approval of the Trustee, as evidenced by the execution and authentication thereof. Unless otherwise indicated in a Board
Resolution, Officer’s Certificate or supplemental indenture for a particular series, interest will be calculated on the basis of a 360-day year of twelve 30-day months. 

Each Security shall be dated the date of its authentication. The Securities of each series shall bear interest, if any, from the date, and
such interest shall be payable on the dates, established as contemplated by Section 2.03. 

  
 10 

 The Person in whose name any Security of any series is registered at the close of business
on any record date applicable to a particular series with respect to any interest payment date for such series shall be entitled to receive the interest, if any, payable on such interest payment date notwithstanding any transfer, exchange or
conversion of such Security subsequent to the record date and prior to such interest payment date, except if and to the extent the Issuer shall default in the payment of the interest due on such interest payment date for such series, in which case
such defaulted interest shall be paid to the Persons in whose names Outstanding Securities for such series are registered at the close of business on a subsequent record date (which shall be not less than five Business Days prior to the date of
payment of such defaulted interest) established by notice given by mail by or on behalf of the Issuer to the Holders of Securities not less than 15 days preceding such subsequent record date. The term “record date” as used with
respect to any interest payment date (except a date for payment of defaulted interest) for the Securities of any series shall mean the date specified as such in the terms of the Securities of such series established as contemplated by
Section 2.03, or, if no such date is so established, if such interest payment date is the first day of a calendar month, the 15th day of the immediately preceding calendar month or, if such interest payment date is the 15th day of a calendar
month, the first day of such calendar month, whether or not such record date is a Business Day. 
 Section 2.08
Registration, Transfer and Exchange. The Issuer will keep at each office or agency to be maintained for the purpose as provided in Section 3.02 for each series of Securities a register or registers in which, subject to such
reasonable regulations as it may prescribe, it will provide for the registration of Securities of such series and the registration of transfer of Securities of such series. Such register shall be in written form in the English language or in any
other form capable of being converted into such form within a reasonable time. At all reasonable times such register or registers shall be open for inspection by the Trustee. 

Upon due presentation for registration of transfer of any Security of any series at any such office or agency to be maintained for the purpose
as provided in Section 3.02, the Issuer shall execute and the Trustee shall authenticate and deliver in the name of the transferee or transferees a new Security or Securities of the same series, maturity date, interest rate and original issue
date in authorized denominations for a like aggregate principal amount. 
 At the option of the Holder thereof, Securities of any series
(except a Global Security) may be exchanged for a Security or Securities of such series having authorized denominations and an equal aggregate principal amount, upon surrender of such Securities to be exchanged at the agency of the Issuer that shall
be maintained for such purpose in accordance with Section 3.02 and upon payment, if the Issuer shall so require, of the charges hereinafter provided. Whenever any Securities are so surrendered for exchange, the Issuer shall execute, and the
Trustee shall authenticate and deliver, the Securities which the Holder making the exchange is entitled to receive. All Securities surrendered upon any exchange or transfer provided for in this Indenture shall be promptly cancelled and disposed of
by the Trustee and the Trustee will deliver a certificate of disposition thereof to the Issuer. 
 All Securities presented for registration
of transfer, exchange, redemption or payment shall (if so required by the Issuer or the Trustee) be duly endorsed by, or be accompanied by a written instrument or instruments of transfer in form satisfactory to the Issuer and the Trustee duly
executed by, the Holder or his or her attorney duly authorized in writing. 

  
 11 

 The Issuer may require payment of a sum sufficient to cover any stamp or other tax or other
governmental charge that may be imposed in connection with any exchange or registration of transfer of Securities. No service charge shall be made for any such transaction. 

The Issuer shall not be required to exchange or register a transfer of (a) any Securities of any series for a period of 15 days
immediately preceding the first mailing of notice of redemption of Securities of such series to be redeemed or (b) any Securities selected, called or being called for redemption, in whole or in part, except, in the case of any Security to be
redeemed in part, the portion thereof not so to be redeemed. 
 Notwithstanding any other provision of this Section 2.08, unless and
until it is exchanged in whole or in part for Securities in definitive registered form, a Global Security representing all or a portion of the Securities of a series may not be transferred except as a whole by the Depositary for such series to a
nominee of such Depositary or by a nominee of such Depositary to such Depositary or another nominee of such Depositary or by such Depositary or any such nominee to a successor Depositary for such series or a nominee of such successor Depositary.

 If at any time the Depositary for the Securities of a series notifies the Issuer that it is unwilling or unable to continue as Depositary
for the Securities of such series or if at any time the Depositary for the Securities of a series shall no longer be eligible under Section 2.04, the Issuer shall appoint a successor Depositary with respect to the Securities of such series. If
a successor Depositary for the Securities of such series is not appointed by the Issuer within 90 days after the Issuer receives such notice or becomes aware of such ineligibility, the Issuer’s determination pursuant to Section 2.03 that
the Securities of such series be represented by a Global Security shall no longer be effective and the Issuer will execute, and the Trustee, upon receipt of an Officer’s Certificate for the authentication and delivery of definitive Securities
of such series, will authenticate and deliver, Securities of such series in definitive registered form, in any authorized denominations, in an aggregate principal amount equal to the principal amount of the Global Security or Securities representing
the Securities of such series, in exchange for such Global Security or Securities. 
 The Issuer may at any time and in its sole discretion
determine that the Securities of any series issued in the form of one or more Global Securities shall no longer be represented by a Global Security or Securities. In such event the Issuer will execute, and the Trustee, upon receipt of an
Officer’s Certificate for the authentication and delivery of definitive Securities of such series, will authenticate and deliver, Securities of such series in definitive registered form, in any authorized denominations, in an aggregate
principal amount equal to the principal amount of the Global Security or Securities representing such series, in exchange for such Global Security or Securities. 

The Depositary for such Global Security may surrender such Global Security in exchange in whole or in part for Securities of the same series
in definitive registered form in accordance with the two preceding paragraphs or on such other terms as are acceptable to the Issuer and such Depositary. Thereupon, the Issuer shall execute, and the Trustee shall authenticate and deliver, without
service charge, 

  
 12 

 (i) to the Person specified by such Depositary a new Security or Securities of
the same series, of any authorized denominations as requested by such Person, in an aggregate principal amount equal to and in exchange for such Person’s beneficial interest in the Global Security; and 

(ii) to such Depositary a new Global Security in a denomination equal to the difference, if any, between the principal amount
of the surrendered Global Security and the aggregate principal amount of Securities authenticated and delivered pursuant to clause (i) above. 

Upon the exchange of a Global Security for Securities in definitive registered form, in authorized denominations, such Global Security shall
be cancelled by the Trustee. Securities in definitive registered form issued in exchange for a Global Security pursuant to this Section 2.08 shall be registered in such names and in such authorized denominations as the Depositary for such
Global Security, pursuant to instructions from its direct or indirect participants or otherwise, shall instruct the Trustee. The Trustee shall deliver such Securities to or as directed by the Persons in whose names such Securities are so registered.

 All Securities issued upon any transfer or exchange of Securities shall be valid obligations of the Issuer, evidencing the same debt, and
entitled to the same benefits under this Indenture, as the Securities surrendered upon such transfer or exchange. 
 Section 2.09
Mutilated, Defaced, Destroyed, Lost and Stolen Securities. In case any temporary or definitive Security shall become mutilated, defaced or be destroyed, lost or stolen, the Issuer in its discretion may execute, and upon the written request of
any officer of the Issuer, the Trustee shall authenticate and deliver a new Security of the same series, maturity date, interest rate and original issue date, bearing a number or other distinguishing symbol not contemporaneously outstanding, in
exchange and substitution for the mutilated or defaced Security, or in lieu of and substitution for the Security so destroyed, lost or stolen. In every case the applicant for a substitute Security shall furnish to the Issuer and to the Trustee and
any agent of the Issuer or the Trustee such security or indemnity as may be required by them to indemnify and defend and to save each of them harmless and, in every case of destruction, loss or theft, evidence to their satisfaction of the
destruction, loss or theft of such Security and of the ownership thereof and in the case of mutilation or defacement shall surrender the Security to the Trustee. 

Upon the issuance of any substitute Security, the Issuer may require the payment of a sum sufficient to cover any tax or other governmental
charge that may be imposed in relation thereto and any other expenses (including the fees and expenses of the Trustee) connected therewith. In case any Security which has matured or is about to mature or has been called for redemption in full, or is
being surrendered for conversion in full, shall become mutilated or defaced or be destroyed, lost or stolen, the Issuer may, instead of issuing a substitute Security (with the Holder’s consent, in the case of convertible Securities), pay or
authorize the payment of the same or convert, or authorize conversion of the same (without surrender thereof except in the case of a mutilated or defaced Security), if the applicant for such payment shall furnish to the Issuer and to the Trustee and
any agent of the Issuer or the Trustee such security or indemnity as any of them may require to save each of them harmless, and, in every case of destruction, loss or theft, the applicant shall also furnish to the Issuer and the Trustee and any
agent of the Issuer or the Trustee evidence to their satisfaction of the destruction, loss or theft of such Security and of the ownership thereof. 

  
 13 

 Every substitute Security of any series issued pursuant to the provisions of this Section by
virtue of the fact that any such Security is destroyed, lost or stolen shall constitute an additional contractual obligation of the Issuer, whether or not the destroyed, lost or stolen Security shall be at any time enforceable by anyone and shall be
entitled to all the benefits of (but shall be subject to all the limitations of rights set forth in) this Indenture equally and proportionately with any and all other Securities of such series duly authenticated and delivered hereunder. All
Securities shall be held and owned upon the express condition that, to the extent permitted by law, the foregoing provisions are exclusive with respect to the replacement or payment or conversion of mutilated, defaced or destroyed, lost or stolen
Securities and shall preclude any and all other rights or remedies notwithstanding any law or statute existing or hereafter enacted to the contrary with respect to the replacement or payment of negotiable instruments or other securities without
their surrender. 
 Section 2.10 Cancellation of Securities; Destruction Thereof. All Securities surrendered for exchange
for Securities of the same series or for payment, redemption, registration of transfer, conversion or for credit against any payment in respect of a sinking or analogous fund, if surrendered to the Issuer or any agent of the Issuer or the Trustee,
shall be delivered to the Trustee for cancellation or, if surrendered to the Trustee, shall be cancelled by it; and no Securities shall be issued in lieu thereof except as expressly permitted by any of the provisions of this Indenture. The Trustee
shall dispose of cancelled Securities held by it and deliver a certificate of disposition to the Issuer. If the Issuer shall acquire any of the Securities, such acquisition shall not operate as a redemption or satisfaction of the Debt represented by
such Securities unless and until the same are delivered to the Trustee for cancellation. 
 Section 2.11 Temporary
Securities. Pending the preparation of definitive Securities for any series, the Issuer may execute and the Trustee shall authenticate and deliver temporary Securities for such series (printed, lithographed, typewritten or otherwise reproduced,
in each case in form satisfactory to the Trustee). Temporary Securities of any series shall be issuable in any authorized denomination, and substantially in the form of the definitive Securities of such series but with such omissions, insertions and
variations as may be appropriate for temporary Securities, all as may be determined by the Issuer with the concurrence of the Trustee as evidenced by the execution and authentication thereof. Temporary Securities may contain such reference to any
provisions of this Indenture as may be appropriate. Every temporary Security shall be executed by the Issuer and be authenticated by the Trustee upon the same conditions and in substantially the same manner, and with like effect, as the definitive
Securities. Without unreasonable delay the Issuer shall execute and shall furnish definitive Securities of such series and thereupon temporary Securities of such series may be surrendered in exchange therefor without charge at each office or agency
to be maintained by the Issuer for that purpose pursuant to Section 3.02 and the Trustee shall authenticate and deliver in exchange for such temporary Securities of such series an equal aggregate principal amount of definitive Securities of the
same series having authorized denominations. Until so exchanged, the temporary Securities of any series shall be entitled to the same benefits under this Indenture as definitive Securities of such series, unless the benefits of the temporary
Securities are limited pursuant to Section 2.03. 

  
 14 

 ARTICLE 3 

COVENANTS OF THE ISSUER 

Section 3.01 Payment of Principal and Interest. The Issuer covenants and agrees for the benefit of each series of
Securities that it will duly and punctually pay or cause to be paid the principal of, and interest on, each of the Securities of such series (together with any additional amounts payable pursuant to the terms of such Securities) at the place or
places, at the respective times and in the manner provided in such Securities and in this Indenture. The interest on Securities (together with any additional amounts payable pursuant to the terms of such Securities) shall be payable only to or upon
the written order of the Holders thereof and at the option of the Issuer may be paid by mailing checks for such interest payable to or upon the written order of such Holders at their last addresses as they appear on the Security register of the
Issuer. 
 Section 3.02 Offices for Payments, Etc. The Issuer will maintain (i) in
            , an agency where the Securities of each series may be presented for payment, an agency where the Securities of each series may be presented for exchange and conversion,
if applicable, as provided in this Indenture and an agency where the Securities of each series may be presented for registration of transfer as in this Indenture provided and (ii) such further agencies in such places as may be determined for
the Securities of such series pursuant to Section 2.03. 
 The Issuer will maintain in
            , an agency where notices and demands to or upon the Issuer in respect of the Securities of any series or this Indenture may be served. 

The Issuer will give to the Trustee written notice of the location of each such agency and of any change of location thereof. In case the
Issuer shall fail to maintain any agency required by this Section to be located in             , or shall fail to give such notice of the location or of any change in the location of
any of the above agencies, presentations and demands may be made and notices may be served at the Corporate Trust Office of the Trustee. 

The Issuer may from time to time designate one or more additional agencies where the Securities of a series may be presented for
payment, where the Securities of that series may be presented for exchange or conversion, if applicable, as provided in this Indenture and pursuant to Section 2.03 and where the Securities of that series may be presented for registration of
transfer as in this Indenture provided, and the Issuer may from time to time rescind any such designation, as the Issuer may deem desirable or expedient; provided, however, that no such designation or rescission shall in any manner
relieve the Issuer of its obligation to maintain the agencies provided for in this Section. The Issuer will give to the Trustee prompt written notice of any such designation or rescission thereof. 

  
 15 

 Section 3.03 Appointment to Fill a Vacancy in Office of Trustee. The Issuer, whenever
necessary to avoid or fill a vacancy in the office of Trustee, will appoint, in the manner provided in Section 6.10, a Trustee, so that there shall at all times be a Trustee with respect to each series of Securities hereunder. 

Section 3.04 Paying Agents. Whenever the Issuer shall appoint a paying agent other than the Trustee with respect to the Securities
of any series, it will cause such paying agent to execute and deliver to the Trustee an instrument in which such agent shall agree with the Trustee, subject to the provisions of this Section, 

(a) that it will hold all sums received by it as such agent for the payment of the principal of or interest on the Securities
of such series (whether such sums have been paid to it by the Issuer or by any other obligor on the Securities of such series) in trust for the benefit of the Holders of the Securities of such series or of the Trustee, 

(b) that it will give the Trustee notice of any failure by the Issuer (or by any other obligor on the Securities of such
series) to make any payment of the principal of or interest on the Securities of such series when the same shall be due and payable, and 

(c) that at any time during the continuance of any such failure, upon the written request of the Trustee, it will forthwith
pay to the Trustee all sums so held in trust by such paying agent. 
 The Issuer will, on or prior to each due date of the principal of or
interest on the Securities of such series, deposit with the paying agent a sum sufficient to pay such principal or interest so becoming due, and (unless such paying agent is the Trustee) the Issuer will promptly notify the Trustee of any failure to
take such action. 
 If the Issuer shall act as its own paying agent with respect to the Securities of any series, it will, on or before
each due date of the principal of or interest on the Securities of such series, set aside, segregate and hold in trust for the benefit of the Holders of the Securities of such series a sum sufficient to pay such principal or interest so becoming
due. The Issuer will promptly notify the Trustee of any failure to take such action. 
 Anything in this Section to the contrary
notwithstanding, but subject to Section 10.01, the Issuer may at any time, for the purpose of obtaining a satisfaction and discharge with respect to one or more or all series of Securities hereunder, or for any other reason, pay or cause to be
paid to the Trustee all sums held in trust for any such series by the Issuer or any paying agent hereunder, as required by this Section, such sums to be held by the Trustee upon the trusts herein contained. 

Anything in this Section to the contrary notwithstanding, the agreement to hold sums in trust as provided in this Section is subject to the
provisions of Sections 10.03 and 10.04. 
 Section 3.05 Written Statement to Trustee. So long as any Securities are Outstanding
hereunder, the Issuer will deliver to the Trustee, within 120 days after the end of each fiscal year of the Issuer ending after the date hereof, a written statement covering the previous fiscal year, signed by two of its officers (which need not
comply with Section 11.05), stating that in the course of the performance of their duties as officers of the Issuer they would normally have knowledge of any default by the Issuer in the performance or fulfillment of any covenant, agreement or
condition contained in this Indenture, stating whether or not they have knowledge of any such default and, if so, specifying each such default of which the signers have knowledge and the nature thereof. 

  
 16 

 ARTICLE 4 

SECURITYHOLDERS LISTS AND REPORTS BY THE ISSUER AND THE TRUSTEE 

Section 4.01 Issuer to Furnish Trustee Information as to Names and Addresses of Securityholders. The Issuer covenants and agrees
that it will furnish or cause to be furnished to the Trustee a list in such form as the Trustee may reasonably require of the names and addresses of the Holders of the Securities of each series pursuant to Section 312 of the Trust Indenture Act
of 1939: 
 (a) semiannually and not more than 15 days after each record date for the payment of interest on such Securities,
as hereinabove specified, as of such record date and on dates to be determined pursuant to Section 2.03 for non-interest bearing Securities in each year, and 

(b) at such other times as the Trustee may request in writing, within 30 days after receipt by the Issuer of any such request
as of a date not more than 15 days prior to the time such information is furnished, provided, that, if and so long as the Trustee shall be the Security registrar (the “Security Registrar”) for such series, such list shall not
be required to be furnished. 
 Section 4.02 Reports by the Issuer. The Issuer covenants to comply with Section 314(a) of
the Trust Indenture Act insofar as it relates to information, documentations, and other reports which the Issuer may be required to file with the Commission pursuant to Section 13 or Section 15(d) of the Securities Exchange Act of 1934.

 Section 4.03 Reports by the Trustee. Any Trustee’s report required under Section 313(a) of the Trust Indenture Act
of 1939 shall be transmitted on or before              in each year following the date hereof, so long as any Securities are Outstanding hereunder, and shall be dated as of a date
convenient to the Trustee but no more than 60 nor less than 45 days prior thereto. The Trustee shall comply with Sections 313(b), 313(c) and 313(d) of the Trust Indenture Act. 

Section 4.04 Preservation of Information; Communication with Securityholders. (a) The Trustee shall preserve, in as current a
form as is reasonably practicable, all information as to the names and addresses of the holders of Securities contained in the most recent list furnished to it as provided in Section 4.01 and as to the names and addresses of holders of
Securities received by the Trustee in its capacity as Security Registrar (if acting in such capacity). 
 (b) The Trustee
may destroy any list furnished to it as provided in Section 4.01 upon receipt of a new list so furnished. 

  
 17 

 (c) Securityholders may communicate as provided in Section 312(b) of the
Trust Indenture Act with other Securityholders with respect to their rights under this Indenture or under the Securities. The Issuer, the Trustee, the Security Registrar and any other Person shall have the protection of Section 312(c) of the
Trust Indenture Act. 
 ARTICLE 5 

REMEDIES OF THE TRUSTEE AND SECURITYHOLDERS ON EVENT OF DEFAULT 

Section 5.01 Event of Default Defined; Acceleration of Maturity; Waiver of Default. “Event of Default”, with
respect to Securities of any series wherever used herein, means each one of the following events which shall have occurred and be continuing (whatever the reason for such Event of Default and whether it shall be voluntary or involuntary or be
effected by operation of law or pursuant to any judgment, decree or order of any court or any order, rule or regulation of any administrative or governmental body): 

(a) default in the payment of any installment of interest upon any of the Securities of such series as and when the same shall
become due and payable, and continuance of such default for a period of 30 days (or such other period as may be established for the Securities of such series as contemplated by Section 2.03); or 

(b) default in the payment of all or any part of the principal on any of the Securities of such series as and when the same
shall become due and payable either at maturity, upon redemption, by declaration or otherwise (and, if established for the Securities of such series as contemplated by Section 2.03, the continuance of such default for a specified period); or

 (c) default in the performance, or breach, of any covenant or agreement of the Issuer in respect of the Securities of
such series (other than a covenant or agreement in respect of the Securities of such series a default in the performance or breach of which is elsewhere in this Section specifically dealt with), and continuance of such default or breach for a period
of 90 days after there has been given, by registered or certified mail, to the Issuer by the Trustee or to the Issuer and the Trustee by the Holders of at least 25% in principal amount of the Outstanding Securities of all series affected thereby, a
written notice specifying such default or breach and requiring it to be remedied and stating that such notice is a “Notice of Default” hereunder; or 

(d) a court having jurisdiction in the premises shall enter a decree or order for relief in respect of the Issuer in an
involuntary case under any applicable bankruptcy, insolvency or other similar law now or hereafter in effect, or appointing a receiver, liquidator, assignee, custodian, trustee or sequestrator (or similar official) of the Issuer or for all or
substantially all of its property and assets or ordering the winding up or liquidation of its affairs, and such decree or order shall remain unstayed and in effect for a period of 90 consecutive days; or 

(e) the Issuer shall commence a voluntary case under any applicable bankruptcy, insolvency or other similar law now or
hereafter in effect, or consent to the entry of an order for relief in an involuntary case under any such law, or consent to the appointment of or taking possession by a receiver, liquidator, assignee, custodian, trustee or sequestrator (or similar
official) of the Issuer or for any substantial part of its property and assets, or make any general assignment for the benefit of creditors; or 

  
 18 

 (f) any other Event of Default provided for in such series of Securities. 

If an Event of Default described in clauses (a), (b), (c) or (f) occurs and is continuing, then, and in each and every such case,
unless the principal of all of the Securities of such series shall have already become due and payable, either the Trustee or the Holders of not less than 25% in aggregate principal amount of the Securities of such series then Outstanding hereunder
(each such series voting as a separate class) by notice in writing to the Issuer (and also to the Trustee if given by Securityholders), may declare the entire principal (or, if the Securities of such series are Original Issue Discount Securities,
such portion of the principal amount as may be specified in the terms of such series) of all Securities of such series and the interest accrued thereon, if any, to be due and payable immediately, and upon any such declaration the same shall become
immediately due and payable. If an Event of Default described in clauses (d) or (e) occurs and is continuing, then and in each and every such case, the entire principal (or, if any Securities are Original Issue Discount Securities, such
portion of the principal as may be specified in the terms thereof) of all the Securities then Outstanding and interest accrued thereon, if any, shall become immediately due and payable. 

The foregoing provisions, however, are subject to the condition that if, at any time after the principal of the Securities of any series shall
have been so declared due and payable, and before any judgment or decree for the payment of the moneys due shall have been obtained or entered as hereinafter provided, the Issuer shall pay or shall deposit with the Trustee a sum sufficient to pay
all matured installments of interest upon all the Securities of such series and the principal of any and all Securities of such series which shall have become due otherwise than by acceleration (with interest upon such principal and, to the extent
that payment of such interest is enforceable under applicable law, on overdue installments of interest, at the same rate as the rate of interest specified in the Securities of such series to the date of such payment or deposit) and such amount as
shall be sufficient to cover reasonable compensation to the Trustee, its agents, attorneys and counsel, and all other expenses and liabilities incurred, and all advances made, by the Trustee except as a result of negligence or bad faith, and if any
and all Events of Default under the Indenture with respect to such series, other than the non-payment of the principal of Securities of such series which shall have become due solely by such acceleration, shall have been cured, waived or otherwise
remedied as provided herein, then and in every such case the Holders of a majority in aggregate principal amount of all the Securities of such series then Outstanding, by written notice to the Issuer and to the Trustee, may waive all defaults with
respect to such series and rescind and annul such declaration and its consequences, but no such waiver or rescission and annulment shall extend to or shall affect any subsequent default or shall impair any right consequent thereon. 

Unless otherwise indicated in the Board Resolution, Officer’s Certificate or supplemental indenture for a series of Original Issue
Discount Securities, for all purposes under this Indenture, if a portion of the principal of any Original Issue Discount Securities shall have been accelerated and declared due and payable pursuant to the provisions hereof, then, from and after such
declaration, unless such declaration has been rescinded and annulled, the principal amount of such Original Issue Discount Securities shall be deemed, for all purposes hereunder, to be such portion of the principal thereof as shall be due and
payable as a result of such acceleration, and payment of such portion of the principal thereof as shall be due and payable as a result of such acceleration, together with interest, if any, thereon and all other amounts owing thereunder, shall
constitute payment in full of such Original Issue Discount Securities. 

  
 19 

 Section 5.02 Collection of Debt by Trustee; Trustee May Prove Debt. The Issuer
covenants that (a) in case default shall be made in the payment of any installment of interest on any of the Securities of any series when such interest shall have become due and payable, and such default shall have continued for a period of 30
days or (b) in case default shall be made in the payment of all or any part of the principal of any of the Securities of any series when the same shall have become due and payable, whether upon maturity of the Securities of such series or upon
any redemption or by declaration or otherwise—then, upon demand of the Trustee, the Issuer will pay to the Trustee for the benefit of the Holders of the Securities of such series the whole amount that then shall have become due and payable on
all Securities of such series for principal or interest, as the case may be (with interest to the date of such payment upon the overdue principal and, to the extent that payment of such interest is enforceable under applicable law, on overdue
installments of interest at the same rate as the rate of interest or Yield to Maturity (in the case of Original Issue Discount Securities) specified in the Securities of such series); and, in addition thereto, such further amount as shall be
sufficient to cover the costs and expenses of collection, including reasonable compensation to the Trustee and each predecessor trustee, their respective agents, attorneys and counsel, and any expenses and liabilities incurred, and all advances
made, by the Trustee and each predecessor trustee except as a result of its negligence or bad faith. 
 In case the Issuer shall fail
forthwith to pay such amounts upon such demand, the Trustee, in its own name and as trustee of an express trust, shall be entitled and empowered to institute any action or proceedings at law or in equity for the collection of the sums so due and
unpaid, and may prosecute any such action or proceedings to judgment or final decree, and may enforce any such judgment or final decree against the Issuer or other obligor upon such Securities and collect in the manner provided by law out of the
property of the Issuer or other obligor upon such Securities, wherever situated, the moneys adjudged or decreed to be payable. 
 In case
there shall be pending proceedings relative to the Issuer or any other obligor upon the Securities under Title 11 of the United States Code or any other applicable Federal or state bankruptcy, insolvency or other similar law, or in case a receiver,
assignee or trustee in bankruptcy or reorganization, liquidator, sequestrator or similar official shall have been appointed for or taken possession of the Issuer or its property or such other obligor or its property, or in case of any other
comparable judicial proceedings relative to the Issuer or other obligor upon the Securities of any series, or to the creditors or property of the Issuer or such other obligor, the Trustee, irrespective of whether the principal of any Securities
shall then be due and payable as therein expressed or by declaration or otherwise and irrespective of whether the Trustee shall have made any demand pursuant to the provisions of this Section, shall be entitled and empowered, by intervention in such
proceedings or otherwise: 

  
 20 

 (i) to file and prove a claim or claims for the whole amount of principal and
interest (or, if the Securities of any series are Original Issue Discount Securities, such portion of the principal amount as may be specified in the terms of such series) owing and unpaid in respect of the Securities of any series, and to file such
other papers or documents as may be necessary or advisable in order to have the claims of the Trustee (including any claim for reasonable compensation to the Trustee and each predecessor trustee, and their respective agents, attorneys and counsel,
and for reimbursement of all expenses and liabilities incurred, and all advances made, by the Trustee and each predecessor trustee, except as a result of negligence or bad faith) and of the Securityholders allowed in any judicial proceedings
relative to the Issuer or other obligor upon the Securities of any series, or to the creditors or property of the Issuer or such other obligor, 

(ii) unless prohibited by applicable law and regulations, to vote on behalf of the Holders of the Securities of any series in
any election of a trustee or a standby trustee in arrangement, reorganization, liquidation or other bankruptcy or insolvency proceedings or person performing similar functions in comparable proceedings, and 

(iii) to collect and receive any moneys or other property payable or deliverable on any such claims, and to distribute all
amounts received with respect to the claims of the Securityholders and of the Trustee on their behalf; and any trustee, receiver or liquidator, custodian or other similar official is hereby authorized by each of the Securityholders to make payments
to the Trustee, and, in the event that the Trustee shall consent to the making of payments directly to the Securityholders, to pay to the Trustee such amounts as shall be sufficient to cover reasonable compensation to the Trustee, each predecessor
trustee and their respective agents, attorneys and counsel, and all other expenses and liabilities incurred, and all advances made, by the Trustee and each predecessor trustee except as a result of negligence or bad faith and all other amounts due
to the Trustee or any predecessor trustee pursuant to Section 6.06. 
 Nothing herein contained shall be deemed to authorize the
Trustee to authorize or consent to or vote for or accept or adopt on behalf of any Securityholder any plan of reorganization, arrangement, adjustment or composition affecting the Securities of any series or the rights of any Holder thereof, or to
authorize the Trustee to vote in respect of the claim of any Securityholder in any such proceeding except, as aforesaid, to vote for the election of a trustee in bankruptcy or similar person. 

All rights of action and of asserting claims under this Indenture, or under any of the Securities of any series, may be enforced by the
Trustee without the possession of any of the Securities of such series or the production thereof on any trial or other proceedings relative thereto, and any such action or proceedings instituted by the Trustee shall be brought in its own name as
trustee of an express trust, and any recovery of judgment, subject to the payment of the expenses, disbursements and compensation of the Trustee, each predecessor trustee and their respective agents and attorneys, shall be for the ratable benefit of
the Holders of the Securities in respect of which such action was taken. 

  
 21 

 In any proceedings brought by the Trustee (and also any proceedings involving the interpretation
of any provision of this Indenture to which the Trustee shall be a party), the Trustee shall be held to represent all the Holders of the Securities in respect to which such action was taken, and it shall not be necessary to make any Holders of such
Securities parties to any such proceedings. 
 Section 5.03 Application of Proceeds. Any moneys collected by the Trustee
pursuant to this Article in respect of any series shall be applied in the following order at the date or dates fixed by the Trustee and, in case of the distribution of such moneys on account of principal or interest, upon presentation of the several
Securities in respect of which monies have been collected and stamping (or otherwise noting) thereon the payment, or issuing Securities of such series in reduced principal amounts in exchange for the presented Securities of like series if only
partially paid, or upon surrender thereof if fully paid: 
 FIRST: To the payment of all amounts due to the Trustee or any
predecessor trustee pursuant to Section 6.06; 
 SECOND: In case the principal of the Securities of such series in
respect of which moneys have been collected shall not have become and be then due and payable, to the payment of interest on the Securities of such series in default in the order of the maturity of the installments of such interest, with interest
(to the extent that such interest has been collected by the Trustee) upon the overdue installments of interest, to the extent permitted by applicable law, at the same rate as the rate of interest or Yield to Maturity (in the case of Original Issue
Discount Securities) specified in such Securities, such payments to be made ratably to the Persons entitled thereto, without discrimination or preference; 

THIRD: In case the principal of the Securities of such series in respect of which moneys have been collected shall have become
and shall be then due and payable, to the payment of the whole amount then owing and unpaid upon all the Securities of such series for principal and interest, with interest upon the overdue principal, and (to the extent that such interest has been
collected by the Trustee) upon overdue installments of interest, to the extent permitted by applicable law, at the same rate as the rate of interest or Yield to Maturity (in the case of Original Issue Discount Securities) specified in the Securities
of such series; and in case such moneys shall be insufficient to pay in full the whole amount so due and unpaid upon the Securities of such series, then to the payment of such principal and interest, without preference or priority of principal over
interest, or of interest over principal, or of any installment of interest over any other installment of interest, or of any Security of such series over any other Security of such series, ratably to the aggregate of such principal and accrued and
unpaid interest; and 
 FOURTH: To the payment of the remainder, if any, to the Issuer or any other Person lawfully entitled
thereto. 
 Section 5.04 Suits for Enforcement. In case an Event of Default has occurred, has not been waived and is continuing,
the Trustee may in its discretion proceed to protect and enforce the rights vested in it by this Indenture by such appropriate judicial proceedings as the Trustee shall deem most effectual to protect and enforce any such rights, either at law or in
equity or in bankruptcy or otherwise, whether for the specific enforcement of any covenant or agreement contained in this Indenture or in aid of the exercise of any power granted in this Indenture or to enforce any other legal or equitable right
vested in the Trustee by this Indenture or by law. 

  
 22 

 Section 5.05 Restoration of Rights on Abandonment of Proceedings. In case the
Trustee shall have proceeded to enforce any right under this Indenture and such proceedings shall have been discontinued or abandoned for any reason, or shall have been determined adversely to the Trustee, then and in every such case (subject to any
determination in such proceeding) the Issuer and the Trustee shall be restored respectively to their former positions and rights hereunder, and all rights, remedies and powers of the Issuer, the Trustee and the Securityholders shall continue as
though no such proceedings had been taken.  
 Section 5.06 Limitations on Suits by Securityholders. No Holder of
any Security of any series shall have any right by virtue or by availing of any provision of this Indenture to institute any action or proceeding at law or in equity or in bankruptcy or otherwise upon or under or with respect to this Indenture, or
for the appointment of a trustee, receiver, liquidator, custodian or other similar official or for any other remedy hereunder, unless such Holder previously shall have given to the Trustee written notice of default and of the continuance thereof, as
hereinbefore provided, and unless also the Holders of not less than 25% in aggregate principal amount of the Securities of such series then Outstanding shall have made written request upon the Trustee to institute such action or proceedings in its
own name as trustee hereunder and shall have offered to the Trustee such reasonable indemnity as it may require against the costs, expenses and liabilities to be incurred therein or thereby and the Trustee for 60 days after its receipt of such
notice, request and offer of indemnity shall have failed to institute any such action or proceeding and no direction inconsistent with such written request shall have been given to the Trustee pursuant to Section 5.09; it being understood and
intended, and being expressly covenanted by the Holder of every Security with every other Holder and the Trustee, that no one or more Holders of Securities of any series shall have any right in any manner whatever by virtue or by availing of any
provision of this Indenture to affect, disturb or prejudice the rights of any other such Holder of Securities, or to obtain or seek to obtain priority over or preference to any other such Holder or to enforce any right under this Indenture, except
in the manner herein provided and for the equal, ratable and common benefit of all Holders of Securities of the applicable series. For the protection and enforcement of the provisions of this Section, each and every Securityholder and the Trustee
shall be entitled to such relief as can be given either at law or in equity. 
 Section 5.07 Unconditional Right of
Securityholders to Institute Certain Suits. Notwithstanding any other provision in this Indenture and any provision of any Security, the right of any Holder of any Security to receive payment of the principal of and interest on such Security on
or after the respective due dates expressed in such Security in accordance with the terms hereof and thereof, or to institute suit for the enforcement of any such payment on or after such respective dates, shall not be impaired or affected without
the consent of such Holder; it being understood and intended, and being expressly covenanted by the Holder of every Security with every other Holder and the Trustee, that no one or more Holders of Securities of any series shall have any right in any
manner whatever by virtue or by availing of any provision of this Indenture to affect, disturb or prejudice the rights of any other such Holder of Securities, or to obtain or seek to obtain priority over or preference to any other such Holder or to
enforce any right under this Indenture, except in the manner herein provided and for the equal, ratable and common benefit of all Holders of Securities of the applicable series. For the protection and enforcement of the provisions of this Section,
each and every Securityholder and the Trustee shall be entitled to such relief as can be given either at law or in equity. 

  
 23 

 Section 5.08 Powers and Remedies Cumulative; Delay or Omission Not Waiver of Default.
Except as provided in Section 5.06, no right or remedy herein conferred upon or reserved to the Trustee or to the Holders of Securities is intended to be exclusive of any other right or remedy, and every right and remedy shall, to the extent
permitted by law, be cumulative and in addition to every other right and remedy given hereunder or now or hereafter existing at law or in equity or otherwise. The assertion or employment of any right or remedy hereunder, or otherwise, shall not
prevent the concurrent assertion or employment of any other appropriate right or remedy. 
 No delay or omission of the Trustee or of any
Holder of Securities to exercise any right or power accruing upon any Event of Default occurring and continuing as aforesaid shall impair any such right or power or shall be construed to be a waiver of any such Event of Default or an acquiescence
therein; and, subject to Section 5.06, every power and remedy given by this Indenture or by law to the Trustee or to the Holders of Securities may be exercised from time to time, and as often as shall be deemed expedient, by the Trustee or by
the Holders of Securities. 
 Section 5.09 Control by Holders of Securities. The Holders of a majority in aggregate principal
amount of the Securities of each series affected (with each series voting as a separate class) at the time Outstanding shall have the right to direct the time, method and place of conducting any proceeding for any remedy available to the Trustee, or
exercising any trust or power conferred on the Trustee with respect to the Securities of such series by this Indenture; provided, that such direction shall not be otherwise than in accordance with law and the provisions of this Indenture and
provided, further, that (subject to the provisions of Section 6.01) the Trustee shall have the right to decline to follow any such direction if the Trustee, being advised by counsel, shall determine that the action or proceeding so directed may
not lawfully be taken or if the Trustee in good faith by its board of directors, the executive committee, or a trust committee of directors or Responsible Officers of the Trustee shall determine that the action or proceedings so directed would
involve the Trustee in personal liability or if the Trustee in good faith shall so determine that the actions or forbearances specified in or pursuant to such direction would be unduly prejudicial to the interests of Holders of the Securities of all
series so affected not joining in the giving of said direction, it being understood that (subject to Section 6.01) the Trustee shall have no duty to ascertain whether or not such actions or forbearances are unduly prejudicial to such Holders.

 Nothing in this Indenture shall impair the right of the Trustee in its discretion to take any action deemed proper by the Trustee and
which is not inconsistent with such direction or directions by Securityholders. 

  
 24 

 Section 5.10 Waiver of Past Defaults. The Holders of a majority in aggregate
principal amount of the Securities of such series at the time Outstanding, by notice to the Trustee, may on behalf of the Holders of all the Securities of such series waive any existing default in the performance of any of the covenants contained
herein or established pursuant to Section 2.03 with respect to such series and its consequences, except an uncured default in the payment of the principal of, or interest on, any of the Securities of that series as and when the same shall
become due by the terms of such Securities; and may rescind an acceleration and its consequences, including any related payment default that resulted from such acceleration. In the case of any such waiver, the Issuer, the Trustee and the Holders of
the Securities of such series shall be restored to their former positions and rights hereunder, respectively, such default shall cease to exist and be deemed to have been cured and not to have occurred, and any Event of Default arising therefrom
shall be deemed to have been cured, and not to have occurred for every purpose of this Indenture; but no such waiver shall extend to any subsequent or other default or Event of Default or impair any right consequent thereon. 

Section 5.11 Trustee to Give Notice of Default. The Trustee shall, within 90 days after the occurrence of a default with respect
to the Securities of any series, give notice of all defaults with respect to that series known to the Trustee to all Holders of Securities of such series in the manner and to the extent provided in Section 4.03, unless in each case such
defaults shall have been cured before the mailing or publication of such notice (the term “defaults” for the purpose of this Section being hereby defined to mean any event or condition which is, or with notice or lapse of time or
both would become, an Event of Default); provided, that, except in the case of default in the payment of the principal of or interest on any of the Securities of such series, or in the payment of any sinking fund installment on such series,
the Trustee shall be protected in withholding such notice if and so long as the board of directors, the executive committee, or a trust committee of directors or trustees and/or Responsible Officers of the Trustee in good faith determines that the
withholding of such notice is in the interests of the Securityholders of such series. 
 Section 5.12 Right of Court to Require
Filing of Undertaking to Pay Costs. All parties to this Indenture agree, and each Holder of any Security by his or her acceptance thereof shall be deemed to have agreed, that any court may in its discretion require, in any suit for the
enforcement of any right or remedy under this Indenture or in any suit against the Trustee for any action taken, suffered or omitted by it as Trustee, the filing by any party litigant in such suit of an undertaking to pay the costs of such suit, and
that such court may in its discretion assess reasonable costs, including reasonable attorneys’ fees, against any party litigant in such suit, having due regard to the merits and good faith of the claims or defenses made by such party litigant;
but the provisions of this Section shall not apply to any suit instituted by the Trustee, to any suit instituted by any Securityholder or group of Securityholders of any series holding in the aggregate more than 10% in aggregate principal amount of
the Securities of such series, or to any suit instituted by any Securityholder for the enforcement of the payment of the principal of or interest on any Security of such series, on or after the respective due dates expressed in such Security or
established pursuant to this Indenture. 

  
 25 

 ARTICLE 6 

CONCERNING THE TRUSTEE 

Section 6.01 Duties and Responsibilities of the Trustee; During Default; Prior to Default. With respect to the Holders of any
series of Securities issued hereunder, the Trustee, prior to the occurrence of an Event of Default with respect to the Securities of a particular series and after the curing or waiving of all Events of Default which may have occurred with respect to
such series, undertakes to perform such duties and only such duties as are specifically set forth in this Indenture. In case an Event of Default with respect to the Securities of a series has occurred (which has not been cured or waived), the
Trustee shall exercise such of the rights and powers vested in it by this Indenture, and use the same degree of care and skill in their exercise, as a prudent person would exercise or use under the circumstances in the conduct of his or her own
affairs. 
 No provision of this Indenture shall be construed to relieve the Trustee from liability for its own negligent action, its own
negligent failure to act or its own willful misconduct. 
 Section 6.02 Certain Rights of the Trustee. In furtherance of and
subject to the Trust Indenture Act of 1939 and subject to Section 6.01: 
 (a) in the absence of bad faith on the part
of the Trustee, the Trustee may conclusively rely, as to the truth of the statements and the correctness of the opinions expressed therein, upon any statements, certificates or opinions furnished to the Trustee and conforming to the requirements of
this Indenture; but, in the case of any such statements, certificates or opinions which by any provision hereof are specifically required to be furnished to the Trustee, the Trustee shall be under a duty to examine the same to determine whether or
not they conform to the requirements of this Indenture; 
 (b) the Trustee shall not be liable for any error of judgment
made in good faith by a Responsible Officer or Responsible Officers of the Trustee, unless it shall be proved that the Trustee was negligent in ascertaining the pertinent facts; 

(c) the Trustee shall not be liable with respect to any action taken or omitted to be taken by it in good faith in accordance
with the direction of the Holders pursuant to Section 5.09 relating to the time, method and place of conducting any proceeding for any remedy available to the Trustee, or exercising any trust or power conferred upon the Trustee, under this
Indenture; 
 (d) none of the provisions contained in this Indenture shall require the Trustee to expend or risk its own
funds or otherwise incur personal financial liability in the performance of any of its duties or in the exercise of any of its rights or powers if there shall be reasonable ground for believing that the repayment of such funds or adequate indemnity
against such liability is not reasonably assured to it; 
 (e) the Trustee may rely and shall be protected in acting or
refraining from acting upon any resolution, Officer’s Certificate or any other certificate, statement, instrument, opinion, report, notice, request, consent, order, bond, debenture, note, security or other paper or document believed by it to be
genuine and to have been signed or presented by the proper party or parties; 

  
 26 

 (f) any request, direction, order or demand of the Issuer mentioned herein shall
be sufficiently evidenced by an Officer’s Certificate (unless other evidence in respect thereof be herein specifically prescribed); and any resolution of the Board of Directors may be evidenced to the Trustee by a copy thereof certified by the
secretary or an assistant secretary of the Issuer; 
 (g) the Trustee may consult with counsel and any advice or Opinion of
Counsel shall be full and complete authorization and protection in respect of any action taken, suffered or omitted to be taken by it hereunder in good faith and in accordance with such advice or Opinion of Counsel; 

(h) the Trustee shall be under no obligation to exercise any of the trusts or powers vested in it by this Indenture at the
request, order or direction of any of the Securityholders pursuant to the provisions of this Indenture, unless such Securityholders shall have offered to the Trustee reasonable security or indemnity against the costs, expenses and liabilities which
might be incurred therein or thereby; 
 (i) the Trustee shall not be liable for any action taken or omitted by it in good
faith and believed by it to be authorized or within the discretion, rights or powers conferred upon it by this Indenture; 

(j) prior to the occurrence of an Event of Default hereunder and after the curing or waiving of all Events of Default, the
Trustee shall not be bound to make any investigation into the facts or matters stated in any resolution, certificate, statement, instrument, opinion, report, notice, request, consent, order, approval, appraisal, bond, debenture, note, security, or
other paper or document unless requested in writing so to do by the Holders of not less than a majority in aggregate principal amount of the Securities of all series affected then Outstanding; provided, that, if the payment within a
reasonable time to the Trustee of the costs, expenses or liabilities likely to be incurred by it in the making of such investigation is, in the opinion of the Trustee, not reasonably assured to the Trustee by the security afforded to it by the terms
of this Indenture, the Trustee may require reasonable indemnity against such expenses or liabilities as a condition to proceeding; the reasonable expenses of every such investigation shall be paid by the Issuer or, if paid by the Trustee or any
predecessor trustee, shall be repaid by the Issuer upon demand; and 
 (k) the Trustee may execute any of the trusts or
powers hereunder or perform any duties hereunder either directly or by or through agents or attorneys not regularly in its employ and the Trustee shall not be responsible for any misconduct or negligence on the part of any such agent or attorney
appointed with due care by it hereunder. 
 Section 6.03 Trustee Not Responsible for Recitals, Disposition of Securities or
Application of Proceeds Thereof. The recitals contained herein and in the Securities, except the Trustee’s certificates of authentication, shall be taken as the statements of the Issuer, and the Trustee assumes no responsibility for the
correctness of the same. The Trustee makes no representation as to the validity or sufficiency of this Indenture or of the Securities. The Trustee shall not be accountable for the use or application by the Issuer of any of the Securities or of the
proceeds thereof. 

  
 27 

 Section 6.04 Trustee and Agents May Hold Securities; Collections, Etc. The Trustee or
any agent of the Issuer or the Trustee, in its individual or any other capacity, may become the owner or pledgee of Securities with the same rights it would have if it were not the Trustee or such agent and may otherwise deal with the Issuer and
receive, collect, hold and retain collections from the Issuer with the same rights it would have if it were not the Trustee or such agent. 

Section 6.05 Moneys Held by Trustee. Subject to the provisions of Section 10.04 hereof, all moneys received by the Trustee
shall, until used or applied as herein provided, be held in trust for the purposes for which they were received, but need not be segregated from other funds except to the extent required by mandatory provisions of law. Neither the Trustee nor any
agent of the Issuer or the Trustee shall be under any liability for interest on any moneys received by it hereunder. 
 Section 6.06
Compensation and Indemnification of Trustee and Its Prior Claim. The Issuer covenants and agrees to pay to the Trustee from time to time, and the Trustee shall be entitled to, such reasonable compensation (which shall not be limited by any
provision of law in regard to the compensation of a trustee of an express trust) as the Issuer and the Trustee may from time to time agree in writing and, except as otherwise expressly provided herein, the Issuer covenants and agrees to pay or
reimburse the Trustee and each predecessor trustee upon its request for all reasonable expenses, disbursements and advances incurred or made by or on behalf of it in accordance with any of the provisions of this Indenture (including the reasonable
compensation and the expenses and disbursements of its counsel and of all agents and other persons not regularly in its employ) except any such expense, disbursement or advance as may arise from its negligence or bad faith. The Issuer also covenants
to indemnify the Trustee and each predecessor trustee for, and to hold it harmless against, any loss, liability or expense incurred without negligence or bad faith on its part, arising out of or in connection with the acceptance or administration of
this Indenture or the trusts hereunder and its duties hereunder, including the costs and expenses of defending itself against or investigating any claim of liability in the premises. The obligations of the Issuer under this Section to compensate and
indemnify the Trustee and each predecessor trustee and to pay or reimburse the Trustee and each predecessor trustee for expenses, disbursements and advances shall constitute additional indebtedness hereunder and shall survive the satisfaction and
discharge of this Indenture. Such additional indebtedness shall be a senior claim to that of the Securities upon all property and funds held or collected by the Trustee as such, except funds held in trust for the benefit of the Holders of particular
Securities, and the Securities are hereby subordinated to such senior claim. 
 Section 6.07 Right of Trustee to Rely on
Officer’s Certificate, Etc. Subject to Sections 6.01 and 6.02, whenever in the administration of the trusts of this Indenture the Trustee shall deem it necessary or desirable that a matter be proved or established prior to taking or
suffering or omitting any action hereunder, such matter (unless other evidence in respect thereof be herein specifically prescribed) may, in the absence of negligence or bad faith on the part of the Trustee, be deemed to be conclusively proved and
established by an Officer’s Certificate delivered to the Trustee, and such certificate, in the absence of negligence or bad faith on the part of the Trustee, shall be full warrant to the Trustee for any action taken, suffered or omitted by it
under the provisions of this Indenture upon the faith thereof. 

  
 28 

 Section 6.08 Disqualification; Conflicting Interests. If the Trustee has or shall
acquire any “conflicting interest” within the meaning of Section 310(b) of the Trust Indenture Act, the Trustee and the Issuer shall in all respects comply with the provisions of Section 310(b) of the Trust Indenture Act. 

Section 6.09 Persons Eligible for Appointment as Trustee. The Trustee for each series of Securities hereunder shall at all times
be a corporation having a combined capital and surplus of at least $50,000,000 and shall be eligible in accordance with the provisions of Section 310(a) of the Trust Indenture Act of 1939. If such corporation publishes reports of condition at
least annually, pursuant to law or to the requirements of a Federal, State or District of Columbia supervising or examining authority, then, for the purposes of this Section, the combined capital and surplus of such corporation shall be deemed to be
its combined capital and surplus as set forth in its most recent report of condition so published. 
 Section 6.10 Resignation and
Removal; Appointment of Successor Trustee. (a) The Trustee, or any trustee or trustees hereafter appointed, may at any time resign with respect to one or more or all series of Securities by giving written notice of resignation to the Issuer
and by mailing notice of such resignation to the Holders of then Outstanding Securities of each series affected at their addresses as they shall appear on the Security register. Upon receiving such notice of resignation, the Issuer shall promptly
appoint a successor trustee or trustees with respect to the applicable series by written instrument in duplicate, executed by authority of the Board of Directors, one copy of which instrument shall be delivered to the resigning Trustee and one copy
to the successor trustee or trustees. If no successor trustee shall have been so appointed with respect to any series and have accepted appointment within 30 days after the mailing of such notice of resignation, the resigning trustee may
petition any court of competent jurisdiction for the appointment of a successor trustee, or any Securityholder who has been a bona fide Holder of a Security or Securities of the applicable series for at least six months may, on behalf of himself or
herself and all others similarly situated, petition any such court for the appointment of a successor trustee. Such court may thereupon, after such notice, if any, as it may deem proper and prescribe, appoint a successor trustee. 

(b) In case at any time any of the following shall occur: 

(i) the Trustee shall fail to comply with the provisions of Section 310(b) of the Trust Indenture Act of 1939 with
respect to any series of Securities after written request therefor by the Issuer or by any Securityholder who has been a bona fide Holder of a Security or Securities of such series for at least six months; or 

  
 29 

 (ii) the Trustee shall cease to be eligible in accordance with the provisions of
Section 310(a) of the Trust Indenture Act of 1939 and shall fail to resign after written request therefor by the Issuer or by any Securityholder; or 

(iii) the Trustee shall become incapable of acting with respect to any series of Securities, or shall be adjudged bankrupt or
insolvent, or a receiver or liquidator of the Trustee or of its property shall be appointed, or any public officer shall take charge or control of the Trustee or of its property or affairs for the purpose of rehabilitation, conservation or
liquidation; 
 then, in any such case, (A) the Issuer may remove the Trustee with respect to the applicable series of Securities and
appoint a successor trustee for such series by written instrument, in duplicate, executed by order of the Board of Directors, one copy of which instrument shall be delivered to the Trustee so removed and one copy to the successor trustee, or,
(B) subject to Section 315(e) of the Trust Indenture Act of 1939, any Securityholder who has been a bona fide Holder of a Security or Securities of such series for at least six months may on behalf of himself or herself and all others
similarly situated, petition any court of competent jurisdiction for the removal of the Trustee and the appointment of a successor trustee with respect to such series. Such court may thereupon, after such notice, if any, as it may deem proper and
prescribe, remove the Trustee and appoint a successor trustee. 
 (c) The Holders of a majority in aggregate principal
amount of the Securities of each series at the time Outstanding may at any time remove the Trustee with respect to Securities of such series and, with the consent of the Issuer, appoint a successor trustee with respect to the Securities of such
series by delivering to the Trustee so removed, to the successor trustee so appointed and to the Issuer the evidence provided for in Section 7.01 of the action in that regard taken by the Securityholders. 

(d) Any resignation or removal of the Trustee with respect to any series and any appointment of a successor trustee with
respect to such series pursuant to any of the provisions of this Section 6.10 shall become effective upon acceptance of appointment by the successor trustee as provided in Section 6.11. 

Section 6.11 Acceptance of Appointment by Successor Trustee. Any successor trustee appointed as provided in Section 6.10
shall execute and deliver to the Issuer and to its predecessor trustee an instrument accepting such appointment hereunder, and thereupon the resignation or removal of the predecessor trustee with respect to all or any applicable series shall become
effective and such successor trustee, without any further act, deed or conveyance, shall become vested with all rights, powers, duties and obligations with respect to such series of its predecessor hereunder, with like effect as if originally named
as trustee for such series hereunder; but, nevertheless, on the written request of the Issuer or of the successor trustee, upon payment of its charges then unpaid, the trustee ceasing to act shall, subject to Section 10.04, pay over to the
successor trustee all moneys at the time held by it hereunder and shall execute and deliver an instrument transferring to such successor trustee all such rights, powers, duties and obligations. Upon request of any such successor trustee, the Issuer
shall execute any and all instruments in writing for more fully and certainly vesting in and confirming to such successor trustee all such rights and powers. Any trustee ceasing to act shall, nevertheless, retain a prior claim upon all property or
funds held or collected by such trustee to secure any amounts then due it pursuant to the provisions of Section 6.06. 

  
 30 

 If a successor trustee is appointed with respect to the Securities of one or more (but not all)
series, the Issuer, the predecessor trustee and each successor trustee with respect to the Securities of any applicable series shall execute and deliver an indenture supplemental hereto which shall contain such provisions as shall be deemed
necessary or desirable to confirm that all the rights, powers, trusts and duties of the predecessor trustee with respect to the Securities of any series as to which the predecessor trustee is not retiring shall continue to be vested in the
predecessor trustee, and shall add to or change any of the provisions of this Indenture as shall be necessary to provide for or facilitate the administration of the trusts hereunder by more than one trustee, it being understood that nothing herein
or in such supplemental indenture shall constitute such trustees co-trustees of the same trust and that each such trustee shall be trustee of a trust or trusts under separate indentures. 

No successor trustee with respect to any series of Securities shall accept appointment as provided in this Section 6.11 unless at the
time of such acceptance such successor trustee shall be qualified under the provisions of Section 310(b) of the Trust Indenture Act of 1939 and eligible under the provisions of Section 310(a) of the Trust Indenture Act of 1939. 

Upon acceptance of appointment by any successor trustee as provided in this Section 6.11, the Issuer shall mail notice thereof to the
Holders of Securities of each series affected, by mailing such notice to such Holders at their addresses as they shall appear on the Security register. If the acceptance of appointment is substantially contemporaneous with the resignation, then the
notice called for by the preceding sentence may be combined with the notice called for by Section 6.10. If the Issuer fails to mail such notice within ten days after acceptance of appointment by the successor trustee, the successor trustee
shall cause such notice to be given at the expense of the Issuer. 
 Section 6.12 Merger, Conversion, Consolidation or Succession to
Business of Trustee. Any corporation into which the Trustee may be merged or converted or with which it may be consolidated, or any corporation resulting from any merger, conversion or consolidation to which the Trustee shall be a party, or any
corporation succeeding to the corporate trust business of the Trustee, shall be the successor of the Trustee hereunder; provided, that such corporation shall be qualified under the provisions of Section 310(b) of the Trust Indenture Act of 1939
and eligible under the provisions of Section 310(a) of the Trust Indenture Act of 1939, without the execution or filing of any paper or any further act on the part of any of the parties hereto, anything herein to the contrary notwithstanding.

 In case, at the time such successor to the Trustee shall succeed to the trusts created by this Indenture, any of the Securities of
any series shall have been authenticated but not delivered, any such successor to the Trustee may adopt the certificate of authentication of any predecessor trustee and deliver such Securities so authenticated; and, in case at that time any of the
Securities of any series shall not have been authenticated, any successor to the Trustee may authenticate such Securities either in the name of any predecessor hereunder or in the name of the successor trustee; and in all such cases such certificate
shall have the full force which it is anywhere in the Securities of such series or in this Indenture provided that the certificate of the Trustee shall have; provided, that the right to adopt the certificate of authentication of any
predecessor trustee or to authenticate Securities of any series in the name of any predecessor trustee shall apply only to its successor or successors by merger, conversion or consolidation. 

  
 31 

 Section 6.13 Preferential Collection of Claims Against the Issuer. The Trustee shall
comply with Section 311(a) of the Trust Indenture Act, excluding any creditor relationship described in Section 311(b) of the Trust Indenture Act. A Trustee who has resigned or been removed shall be subject to Section 311(a) of the
Trust Indenture Act to the extent included therein. 
 ARTICLE 7 

CONCERNING THE SECURITYHOLDERS 

Section 7.01 Evidence of Action Taken by Securityholders. Any request, demand, authorization, direction, notice, consent, waiver
or other action provided by this Indenture to be given or taken by a specified percentage in principal amount of the Securityholders of any or all series may be embodied in and evidenced by one or more instruments of substantially similar tenor
signed by such specified percentage of Securityholders in person or by agent duly appointed in writing; and, except as herein otherwise expressly provided, such action shall become effective when such instrument or instruments are delivered to the
Trustee. Proof of execution of any instrument or of a writing appointing any such agent shall be sufficient for any purpose of this Indenture and (subject to Sections 6.01 and 6.02) conclusive in favor of the Trustee and the Issuer, if made in the
manner provided in this Article. 
 Section 7.02 Proof of Execution of Instruments and of Holding of Securities. Subject to
Sections 6.01 and 6.02, the execution of any instrument by a Holder or his agent or proxy may be proved in accordance with such reasonable rules and regulations as may be prescribed by the Trustee or in such manner as shall be satisfactory to the
Trustee. The holding of Securities shall be proved by the Security register or by a certificate of the registrar thereof. The Issuer may set a record date for purposes of determining the identity of Holders of any series entitled to vote or consent
to any action referred to in Section 7.01, which record date may be set at any time or from time to time by notice to the Trustee, for any date or dates (in the case of any adjournment or reconsideration) not more than 60 days nor less than
five days prior to the proposed date of such vote or consent, and thereafter, notwithstanding any other provisions hereof, only Holders of such series of record on such record date shall be entitled to so vote or give such consent or revoke such
vote or consent. Notice of such record date may be given before or after any request for any action referred to in Section 7.01 is made by the Issuer. 

Section 7.03 Holders to Be Treated as Owners. The Issuer, the Trustee and any agent of the Issuer or of the Trustee may deem and
treat the Person in whose name any Security shall be registered upon the Security register for such series as the absolute owner of such Security (whether or not such Security shall be overdue and notwithstanding any notation of ownership or other
writing thereon) for the purpose of receiving payment of or on account of the principal of, and, subject to the provisions of this Indenture, interest on, such Security and for all other purposes; and neither the Issuer nor the Trustee nor any agent
of the Issuer or the Trustee shall be affected by any notice to the contrary. All such payments so made to any such Person, or upon his or her order, shall be valid, and, to the extent of the sum or sums so paid, effectual to satisfy and discharge
the liability for moneys payable. 

  
 32 

 Section 7.04 Securities Owned by Issuer Deemed Not Outstanding. In determining
whether the Holders of the requisite aggregate principal amount of Outstanding Securities of any or all series have concurred in any direction, consent or waiver under this Indenture, Securities which are owned by the Issuer or any other obligor on
the Securities with respect to which such determination is being made or by any Person directly or indirectly controlling or controlled by or under direct or indirect common control with the Issuer or any other obligor on the Securities with respect
to which such determination is being made shall be disregarded and deemed not to be Outstanding for the purpose of any such determination, except that, for the purpose of determining whether the Trustee shall be protected in relying on any such
direction, consent or waiver, only Securities which the Trustee knows are so owned shall be so disregarded. Securities so owned which have been pledged in good faith may be regarded as Outstanding if the pledgee establishes to the satisfaction of
the Trustee the pledgee’s right so to act with respect to such Securities and that the pledgee is not the Issuer or any other obligor upon the Securities or any Person directly or indirectly controlling or controlled by or under direct or
indirect common control with the Issuer or any other obligor on the Securities. In case of a dispute as to such right, the advice of counsel shall be full protection in respect of any decision made by the Trustee in accordance with such advice. 

Section 7.05 Right of Revocation of Action Taken. At any time prior to (but not after) the evidencing to the Trustee, as provided
in Section 7.01, of the taking of any action by the Holders of the percentage in aggregate principal amount of the Securities of any or all series, as the case may be, specified in this Indenture in connection with such action, any Holder of a
Security the serial number of which is shown by the evidence to be included among the serial numbers of the Securities the Holders of which have consented to such action may, by filing written notice at the Corporate Trust Office and upon proof of
holding as provided in this Article, revoke such action so far as concerns such Security. Except as aforesaid, any such action taken by the Holder of any Security shall be conclusive and binding upon such Holder and upon all future Holders and
owners of such Security and of any Securities issued in exchange or substitution therefor or on registration of transfer thereof, irrespective of whether or not any notation in regard thereto is made upon any such Security. Any action taken by the
Holders of the percentage in aggregate principal amount of the Securities of any or all series, as the case may be, specified in this Indenture in connection with such action shall be conclusively binding upon the Issuer, the Trustee and the Holders
of all the Securities affected by such action. 
 ARTICLE 8 

SUPPLEMENTAL INDENTURES 

Section 8.01 Supplemental Indentures Without Consent of Securityholders. The Issuer, when authorized by a resolution of its Board
of Directors, and the Trustee may from time to time and at any time, without the consent of any of the Securityholders, enter into an indenture or indentures supplemental hereto in form satisfactory to the Trustee for one or more of the following
purposes: 

  
 33 

 (a) to convey, transfer, assign, mortgage or pledge to the Trustee as security
for the Securities of one or more series any property or assets; 
 (b) to evidence the succession of a corporation, limited
liability company, limited company, partnership, trust or similar entity to the Issuer, or successive successions, and the assumption by such successor of the covenants, agreements and obligations of the Issuer pursuant to, or to otherwise comply
with, Article 9; 
 (c) to comply with the requirements of the Commission in order to effect or maintain the qualification
of this Indenture under the Trust Indenture Act of 1939, as amended; 
 (d) to add to the covenants of the Issuer such
further covenants, restrictions, conditions or provisions as its Board of Directors and the Trustee shall consider to be for the protection of the Holders of Securities, and to make the occurrence, or the occurrence and continuance, of a default in
any such additional covenants, restrictions, conditions or provisions an Event of Default permitting the enforcement of all or any of the several remedies provided in this Indenture as herein set forth; provided, that in respect of any such
additional covenant, restriction, condition or provision such supplemental indenture may provide for a particular period of grace after default (which period may be shorter or longer than that allowed in the case of other defaults) or may provide
for an immediate enforcement upon such an Event of Default or may limit the remedies available to the Trustee upon such an Event of Default or may limit the right of the Holders of a majority in aggregate principal amount of the Securities of such
series to waive such an Event of Default; 
 (e) to cure any ambiguity, defect or inconsistency, or to conform this
Indenture or any supplemental indenture to the description of the Securities set forth in any prospectus or prospectus supplement related to such series of Securities; 

(f) to provide for or add guarantors for the Securities of one or more series; 

(g) to establish the form or terms of Securities of any series as permitted by Sections 2.01 and 2.03; 

(h) to evidence and provide for the acceptance of appointment hereunder by a successor trustee with respect to the Securities
of one or more series and to add to or change any of the provisions of this Indenture as shall be necessary to provide for or facilitate the administration of the trusts hereunder by more than one trustee, pursuant to the requirements of
Section 6.11; 
 (i) to add to, delete from or revise the conditions, limitations and restrictions on the authorized
amount, terms, purposes of issue, authentication and delivery of any series of Securities, as herein set forth; 

  
 34 

 (j) to make any change to the Securities of any series so long as no Securities
of such series are Outstanding; and 
 (k) to make any other change that does not adversely affect the interests of the
Holders of the Securities in any material respect. 
 The Trustee shall join with the Issuer in the execution of any such supplemental
indenture, to make any further appropriate agreements and stipulations which may be therein contained and to accept the conveyance, transfer, assignment, mortgage or pledge of any property thereunder, but the Trustee shall not be obligated to enter
into any such supplemental indenture which affects the Trustee’s own rights, duties or immunities under this Indenture or otherwise. 

Any supplemental indenture authorized by the provisions of this Section may be executed without the consent of the Holders of any of the
Securities at the time Outstanding, notwithstanding any of the provisions of Section 8.02. 
 Section 8.02 Supplemental
Indentures With Consent of Securityholders. With the consent (evidenced as provided in Article 7) of the Holders of not less than a majority in aggregate principal amount of the Securities at the time Outstanding of one or more series affected
by such supplemental indenture (voting as separate series), the Issuer, when authorized by a resolution of the Board of Directors, and the Trustee may, from time to time and at any time, enter into an indenture or indentures supplemental hereto for
the purpose of adding any provisions to or changing in any manner or eliminating any of the provisions of this Indenture or of any supplemental indenture or of modifying in any manner the rights of the Holders of the Securities of each such
consenting series; provided, that no such supplemental indenture shall, without the consent of the Holder of each Security so affected, (a) extend the final maturity of any Security, or reduce the principal amount thereof, or reduce the
rate or extend the time of payment of interest thereon, or reduce any amount payable on redemption thereof, or make the principal thereof (including any amount in respect of original issue discount) or interest thereon payable in any currency other
than that provided in the Securities or in accordance with the terms thereof, or reduce the amount of the principal of an Original Issue Discount Security that would be due and payable upon an acceleration of the maturity thereof pursuant to
Section 5.01 or the amount thereof provable in bankruptcy pursuant to Section 5.02, or (b) waive an uncured default in the payment of principal of any Security or interest thereon (except in the case of a rescission of acceleration of
the Securities of such series by the Holders of at least a majority in aggregate principal amount of the Securities of such series at the time Outstanding and a waiver of the payment default that resulted from such acceleration) or change a
provision related to the waiver of past defaults or change or impair the right of any Securityholder to institute suit for the payment or conversion thereof or, if the Securities provide therefor, any right of repayment at the option of the
Securityholder, or (c) modify any of the provisions of this section except to increase any required percentage or to provide that certain other provisions cannot be modified or waived without the consent of the Holder of each Security so
affected, or (d) reduce the aforesaid percentage of Securities of any series, the consent of the Holders of which is required for any such supplemental indenture or the consent of Holders of which is required for any modification, amendment or
waiver of compliance with certain provisions of this Indenture or certain defaults hereunder and their consequences provided for in this Indenture. 

  
 35 

 A supplemental indenture which changes or eliminates any covenant, Event of Default or other
provision of this Indenture (1) that has been expressly included solely for the benefit of one or more particular series of Securities, if any, or (2) which modifies the rights of Holders of Securities of one or more series with respect to
any covenant, Event of Default or provision, shall be deemed not to affect the rights under this Indenture of the Holders of Securities of any other series with respect to which such covenant, Event of Default or other provision has not been
included or so modified. 
 Upon the request of the Issuer, accompanied by a Board Resolution authorizing the execution of any such
supplemental indenture, and upon the filing with the Trustee of evidence of the consent of Securityholders as aforesaid and other documents, if any, required by Section 7.01, the Trustee shall join with the Issuer in the execution of such
supplemental indenture unless such supplemental indenture affects the Trustee’s own rights, duties or immunities under this Indenture or otherwise, in which case the Trustee may in its discretion, but shall not be obligated to, enter into such
supplemental indenture. 
 It shall not be necessary for the consent of the Securityholders under this Section to approve the particular
form of any proposed supplemental indenture, but it shall be sufficient if such consent shall approve the substance thereof. 
 Promptly
after the execution by the Issuer and the Trustee of any supplemental indenture pursuant to the provisions of this Section, the Trustee shall give a notice thereof to the Holders of then Outstanding Securities of each series affected thereby, by
mailing a notice thereof by first-class mail to such Holders at their addresses as they shall appear on the Security register, and in each case such notice shall set forth in general terms the substance of such supplemental indenture. Any failure of
the Trustee to mail such notice, or any defect therein, shall not, however, in any way impair or affect the validity of any such supplemental indenture. 

Section 8.03 Effect of Supplemental Indenture. Upon the execution of any supplemental indenture pursuant to the provisions hereof,
this Indenture shall be and be deemed to be modified and amended in accordance therewith and the respective rights, limitations of rights, obligations, duties and immunities under this Indenture of the Trustee, the Issuer and the Holders of
Securities of each series affected thereby shall thereafter be determined, exercised and enforced hereunder subject in all respects to such modifications and amendments, and all the terms and conditions of any such supplemental indenture shall be
and be deemed to be part of the terms and conditions of this Indenture for any and all purposes. 
 Section 8.04 Documents to Be
Given to Trustee. The Trustee, subject to the provisions of Sections 6.01 and 6.02, may receive an Officer’s Certificate and an Opinion of Counsel as conclusive evidence that any supplemental indenture executed pursuant to this Article 8
complies with the applicable provisions of this Indenture. 

  
 36 

 Section 8.05 Notation on Securities in Respect of Supplemental Indentures. Securities
of any series authenticated and delivered after the execution of any supplemental indenture pursuant to the provisions of this Article may bear a notation in form approved by the Trustee for such series as to any matter provided for by such
supplemental indenture or as to any action taken by Securityholders. If the Issuer or the Trustee shall so determine, new Securities of any series so modified as to conform, in the opinion of the Trustee and the Board of Directors, to any
modification of this Indenture contained in any such supplemental indenture may be prepared by the Issuer, authenticated by the Trustee and delivered in exchange for the Securities of such series then Outstanding. 

ARTICLE 9 
 CONSOLIDATION, MERGER,
SALE OR CONVEYANCE 
 Section 9.01 Issuer May Consolidate, Etc., on Certain Terms. The Issuer shall not consolidate with or
merge into any other Person (in a transaction in which the Issuer is not the surviving corporation) or convey, transfer or lease its properties and assets substantially as an entirety to any Person, unless (a) the Person formed by such
consolidation or into which the Issuer is merged or the Person which acquires by conveyance or transfer, or which leases, the properties and assets of the Issuer substantially as an entirety (i) shall be a corporation, limited liability
company, limited company, partnership, trust or similar entity, (ii) shall be organized and validly existing under the laws of Switzerland, the United Kingdom, any other member state of the European Union or the United States of America, any
political subdivision thereof or any State thereof or the District of Columbia and (iii) shall expressly assume, by an indenture supplemental hereto, executed and delivered to the Trustee, in form satisfactory to the Trustee, the due and
punctual payment of the principal of and interest on all the Securities and the performance or observance of every covenant of this Indenture on the part of the Issuer to be performed, by supplemental indenture satisfactory in form to the Trustee,
executed and delivered to the Trustee, by the Person formed by such consolidation or into which the Issuer shall have been merged or by the Person which shall have acquired the Issuer’s assets; (b) immediately after giving effect to such
transaction, no Event of Default, and no event which, after notice or lapse of time or both, would become an Event of Default, shall have happened and be continuing; and (c) the Issuer has delivered to the Trustee an Officer’s Certificate
and an Opinion of Counsel, each stating that such consolidation, merger, conveyance, transfer or lease and, if a supplemental indenture is required in connection with such transaction, such supplemental indenture comply with this Article and that
all conditions precedent herein provided for relating to such transaction have been complied with. 
 The restrictions in this
Section 9.01 shall not apply to (i) the merger or consolidation of the Issuer with one of its affiliates, if the Board of Directors determines in good faith that the purpose of such transaction is principally to convert the Issuer’s
form of organization to another form, or (ii) the merger of the Issuer with or into a single direct or indirect wholly owned Subsidiary. 

Nothing contained in this Article shall apply to, limit or impose any requirements upon the consolidation or merger of any Person into the
Issuer where the Issuer is the survivor of such transaction, or the acquisition by the Issuer, by purchase or otherwise, of all or any part of the property of any other Person (whether or not affiliated with the Issuer). 

  
 37 

 Section 9.02 Successor Issuer Substituted. Upon any consolidation of the Issuer with,
or merger of the Issuer into, any other Person or any conveyance, transfer or lease of the properties and assets of the Issuer substantially as an entirety in accordance with Section 9.01, the successor Person formed by such consolidation or
into which the Issuer is merged or to which such conveyance, transfer or lease is made shall succeed to, and be substituted for, and may exercise every right and power of, the Issuer under this Indenture with the same effect as if such successor
Person had been named as the Issuer herein, and thereafter, except in the case of a lease, the predecessor Person shall be relieved of all obligations and covenants under this Indenture and the Securities. 

In case of any such consolidation, merger, sale, lease or conveyance, such changes in phraseology and form (but not in substance) may be made
in the Securities thereafter to be issued as may be appropriate. 
 ARTICLE 10 

SATISFACTION AND DISCHARGE OF INDENTURE; DEFEASANCE; UNCLAIMED MONEYS 

Section 10.01 Satisfaction and Discharge of Indenture; Defeasance. (a) If at any time 

(i) the Issuer shall have paid or caused to be paid the principal of and interest on all the Securities of any series
Outstanding hereunder (other than Securities of such series which have been destroyed, lost or stolen and which have been replaced or paid as provided in Section 2.09) as and when the same shall have become due and payable, or 

(ii) the Issuer shall have delivered to the Trustee for cancellation all Securities of any series theretofore authenticated
(other than any Securities of such series which shall have been destroyed, lost or stolen and which shall have been replaced or paid as provided in Section 2.09) or 

(iii) in the case of any series of Securities the exact amount (including the currency of payment) of principal of and
interest due on which on the dates referred to in clause (B) below can be determined at the time of making the deposit referred to in such clause, 

(A) all the Securities of such series not theretofore delivered to the Trustee for cancellation shall have become due and
payable, or are by their terms to become due and payable within one year or are to be called for redemption within one year under arrangements satisfactory to the Trustee for the giving of notice of redemption, and 

  
 38 

 (B) the Issuer shall have irrevocably deposited or caused to be deposited with
the Trustee as trust funds the entire amount in cash (other than moneys repaid by the Trustee or any paying agent to the Issuer in accordance with Section 10.04) or, in the case of any series of Securities the payments on which may only be made
in Dollars, U.S. Government Obligations maturing as to principal and interest in such amounts and at such times as will insure the availability of cash sufficient to pay on any subsequent interest payment date all interest due on such interest
payment date on the Securities of such series and to pay at maturity or upon redemption all Securities of such series (in each case other than any Securities of such series which shall have been destroyed, lost or stolen and which shall have been
replaced or paid as provided in Section 2.09) not theretofore delivered to the Trustee for cancellation, including principal and interest due or to become due to such date of maturity, as the case may be, 

and if, in any such case (i), (ii) or (iii), the Issuer shall also pay or cause to be paid all other sums payable hereunder by the Issuer, including
amounts due the Trustee pursuant to Section 6.06, with respect to Securities of such series, then this Indenture shall cease to be of further effect with respect to Securities of such series (except as to (1) rights of registration of
transfer, conversion and exchange of Securities of such series and the Issuer’s right of optional redemption, (2) substitution of mutilated, defaced, destroyed, lost or stolen Securities, (3) rights of Holders of Securities to
receive, solely from the trust fund described in Section 10.01(a)(iii)(B), payments of principal thereof and interest thereon, upon the original stated due dates therefor (but not upon acceleration) and remaining rights of the Holders to
receive, solely from the trust fund described in Section 10.01(a)(iii)(B), sinking fund payments, if any, (4) the rights (including the Trustee’s rights under Section 10.05) and immunities of the Trustee hereunder and the
Trustee’s obligations under Sections 10.02 and 10.04 and (5) the obligations of the Issuer under Section 3.02), and the Trustee, on demand of the Issuer accompanied by an Officer’s Certificate and an Opinion of Counsel which
complies with Section 11.05 and at the cost and expense of the Issuer, shall execute proper instruments acknowledging such satisfaction of and discharging this Indenture with respect to such series. The Issuer agrees to reimburse the Trustee
for any costs or expenses thereafter reasonably and properly incurred and to compensate the Trustee for any services thereafter reasonably and properly rendered by the Trustee in connection with this Indenture or the Securities of such series. 

(b) The following subsection shall apply to the Securities of each series unless specifically otherwise provided in a Board Resolution,
Officer’s Certificate or indenture supplemental hereto provided pursuant to Section 2.03. In addition to the right to discharge of the Indenture pursuant to subsection (a) above, the Issuer, at its option and at any time, by written
notice by an officer delivered to the Trustee, may elect to have all of its obligations discharged with all Outstanding Securities of a series (“Legal Defeasance”), such discharge to be effective on the date that the conditions set
forth in clauses (i) through (iv) and (vi) of Section 10.01(d) are satisfied, and thereafter the Issuer shall be deemed to have paid and discharged the entire Debt on all the Securities of such a series, and satisfied all its
other obligations under such Securities and this Indenture insofar as such Securities are concerned and this Indenture shall cease to be of further effect with respect to Securities of such series (except as to (1) rights of registration of
transfer, conversion and exchange of Securities of such series, (2) substitution of apparently mutilated, defaced, destroyed, lost or stolen Securities, (3) rights of Holders of Securities to receive, solely from the trust fund described
in Section 10.01(d)(i), payments of principal thereof and interest thereon, upon the original stated due dates therefor (but not upon acceleration) and remaining rights of the Holders to receive, solely from the trust fund described in
Section 10.01(d)(i), sinking fund payments, if any, (4) the rights (including the Trustee’s rights under Section 10.05) and immunities of the Trustee hereunder and the Trustee’s obligations with respect to the Securities of
such series under Sections 10.02 and 10.04 and (5) the obligations of the Issuer under Section 3.02). 

  
 39 

 (c) The following subsection shall apply to the Securities of each series unless specifically
otherwise provided in a Board Resolution, Officer’s Certificate or indenture supplemental hereto provided pursuant to Section 2.03. In addition to the right to discharge of the Indenture pursuant to subsection (a) and to Legal
Defeasance pursuant to subsection (b), above, the Issuer, at its option and at any time, by written notice executed by an officer delivered to the Trustee, may elect to have its obligations under any covenant contained in this Indenture or in the
Board Resolution or supplemental indenture relating to such series pursuant to Section 2.03 discharged with respect to all Outstanding Securities of a series, this Indenture and any indentures supplemental to this Indenture with respect to such
series (“Covenant Defeasance”), such discharge to be effective on the date the conditions set forth in clauses (i) through (iii) and (v) through (vi) of Section 10.01(d) are satisfied, and such Securities
shall thereafter be deemed to be not “Outstanding” for the purposes of any direction, waiver, consent or declaration of Securityholders (and the consequences of any thereof) in connection with such covenants, but shall continue to be
“Outstanding” for all other purposes under this Indenture. For this purpose, such Covenant Defeasance means that, with respect to the Outstanding Securities of a series, the Issuer may omit to comply with and shall have no liability in
respect of any term, condition or limitation set forth in any such covenant, whether directly or indirectly, by reason of any reference elsewhere herein to any such covenant or by reason of reference in any such covenant to any other provision
herein or in any other document and such omission to comply shall not constitute an Event of Default under Section 5.01(c) or otherwise, but except as specified in this Section 10.01(c), the remainder of the Issuer’s obligations under
the Securities of such series, this Indenture, and any indentures supplemental to this Indenture with respect to such series shall be unaffected thereby. 

(d) The following shall be the conditions to the application of Legal Defeasance under subsection (b) or Covenant Defeasance under
subsection (c) to the Securities of the applicable series: 
 (i) the Issuer irrevocably deposits or causes to be
deposited in trust with the Trustee or, at the option of the Trustee, with a trustee satisfactory to the Trustee and the Issuer under the terms of an irrevocable trust agreement in form and substance satisfactory to the Trustee, cash or U.S.
Government Obligations that will generate cash sufficient to pay principal of and interest on the Outstanding Securities of such series to maturity or redemption, as the case may be, and to pay all other amounts payable by it hereunder, provided
that (A) the trustee of the irrevocable trust, if any, shall have been irrevocably instructed to pay such funds or the proceeds of such U.S. Government Obligations to the Trustee and (B) the Trustee shall have been irrevocably instructed
to apply such funds or the proceeds of such U.S. Government Obligations to (x) the principal and interest on all Securities of such series on the date that such principal or interest is due and payable and (y) any mandatory sinking fund
payments on the day on which such payments are due and payable in accordance with the terms of the Indenture and the Securities of such series, and the Issuer shall also pay or cause to be paid all other amounts payable hereunder with respect to
such series; 

  
 40 

 (ii) the Issuer delivers to the Trustee an Officer’s Certificate stating
that all conditions precedent specified herein relating to Legal Defeasance or Covenant Defeasance, as the case may be, have been complied with, and an Opinion of Counsel to the same effect; 

(iii) no Event of Default under subsection (a), (b), (d) or (e) of Section 5.01 shall have occurred and be
continuing, and no event which with notice or lapse of time or both would become such an Event of Default shall have occurred and be continuing, on the date of such deposit; 

(iv) in the event of an election for Legal Defeasance under subsection (b), the Issuer shall have delivered to the Trustee an
Opinion of Counsel stating that (A) the Issuer has received from, or there has been published by, the Internal Revenue Service a ruling or (B) since the date of this instrument, there has been a change in the applicable U.S. Federal income
tax law, in either case (A) or (B) to the effect that, and based thereon such opinion shall confirm that, the Holders of such Securities will not recognize gain or loss for U.S. Federal income tax purposes as a result of the deposit,
defeasance and discharge to be effected with respect to such Securities and will be subject to U.S. Federal income tax on the same amounts, in the same manner and at the same times as would be the case if such deposit, defeasance and discharge were
not to occur; 
 (v) in the event of an election for Covenant Defeasance under subsection (c), the Issuer shall have
delivered to the Trustee an Opinion of Counsel to the effect that the Holders of such Securities will not recognize gain or loss for U.S. Federal income tax purposes as a result of the deposit and Covenant Defeasance to be effected with respect to
such Securities and will be subject to U.S. Federal income tax on the same amount, in the same manner and at the same times as would be the case if such deposit and Covenant Defeasance were not to occur; and 

(vi) notwithstanding any other provisions of this subsection (d), such defeasance shall be effected in compliance with any
additional or substitute terms, conditions or limitations which may be imposed on the Issuer pursuant to Section 2.03. 
 After such irrevocable
deposit made pursuant to this Section 10.01(d) and satisfaction of the other conditions set forth in this subsection (d), the Trustee upon request shall execute proper instruments acknowledging the discharge of the Issuer’s obligations
pursuant to this Section 10.01. 

  
 41 

 Section 10.02 Application by Trustee of Funds Deposited for Payment of Securities.
Subject to Section 10.04, all moneys deposited with the Trustee (or other trustee) pursuant to Section 10.01 shall be held in trust and applied by it to the payment, either directly or through any paying agent (including the Issuer acting
as its own paying agent), to the Holders of the particular Securities of such series for the payment or redemption of which such moneys have been deposited with the Trustee, of all sums due and to become due thereon for principal and interest; but
such money need not be segregated from other funds except to the extent required by law. 
 Section 10.03 Repayment of Moneys Held
by Paying Agent. In connection with the satisfaction and discharge of this Indenture with respect to Securities of any series, all moneys then held by any paying agent under the provisions of this Indenture with respect to such series of
Securities shall, upon demand of the Issuer, be repaid to it or paid to the Trustee and thereupon such paying agent shall be released from all further liability with respect to such moneys. 

Section 10.04 Return of Moneys Held by Trustee and Paying Agent Unclaimed for Two Years. Any moneys deposited with or paid to the
Trustee or any paying agent for the payment of the principal of, interest on or additional amounts in respect of any Security of any series and not applied but remaining unclaimed for two years after the date upon which such principal, interest or
additional amount shall have become due and payable, shall be repaid to the Issuer by the Trustee for such series or such paying agent, and the Holder of the Securities of such series shall thereafter look only to the Issuer for any payment which
such Holder may be entitled to collect, and all liability of the Trustee or any paying agent with respect to such moneys shall thereupon cease. 

Section 10.05 Indemnity for U.S. Government Obligations. The Issuer shall pay and indemnify the Trustee against any tax, fee or
other charge imposed on or assessed against the U.S. Government Obligations deposited pursuant to Section 10.01 or the principal or interest received in respect of such obligations. 

ARTICLE 11 
 MISCELLANEOUS
PROVISIONS 
 Section 11.01 No Recourse. No recourse under or upon any obligation, covenant or agreement of this Indenture, or
of any Security, or for any claim based thereon or otherwise in respect thereof, shall be had against any incorporator, stockholder, officer or director, past, present or future as such, of the Issuer or of any predecessor or successor Person,
either directly or through the Issuer or any such predecessor or successor Person, whether by virtue of any constitution, statute or rule of law, or by the enforcement of any assessment or penalty or otherwise; it being expressly understood that
this Indenture and the obligations issued hereunder are solely corporate obligations, and that no such personal liability whatever shall attach to, or is or shall be incurred by, the incorporators, stockholders, officers or directors as such, of the
Issuer or of any predecessor or successor Person, or any of them, because of the creation of the indebtedness hereby authorized, or under or by reason of the obligations, covenants or agreements contained in this Indenture or in any of the
Securities or implied therefrom; and that any and all such personal liability of every name and nature, either at common law or in equity or by constitution or statute, of, and any and all such rights and claims against, every such incorporator,
stockholder, officer or director as such, because of the creation of the indebtedness hereby authorized, or under or by reason of the obligations, covenants or agreements contained in this Indenture or in any of the Securities or implied therefrom,
are hereby expressly waived and released as a condition of, and as a consideration for, the execution of this Indenture and the issuance of such Securities. 

  
 42 

 Section 11.02 Provisions of Indenture for the Sole Benefit of Parties and Holders of
Securities. Nothing in this Indenture or in the Securities, expressed or implied, shall give or be construed to give to any Person, other than the parties hereto and their successors and the Holders of the Securities any legal or equitable
right, remedy or claim under this Indenture or under any covenant or provision herein contained, all such covenants and provisions being for the sole benefit of the parties hereto and their successors and of the Holders of the Securities. 

Section 11.03 Successors and Assigns of Issuer Bound by Indenture. All the covenants, stipulations, promises and agreements
contained in this Indenture by or on behalf of the Issuer shall bind its successors and assigns, whether so expressed or not. 

Section 11.04 Notices and Demands on Issuer, Trustee and Holders of Securities. Any notice or demand which by any provision of
this Indenture is required or permitted to be given or served by the Trustee or by the Holders of Securities to or on the Issuer may be given or served by being deposited postage prepaid, first-class mail (except as otherwise specifically provided
herein) addressed (until another address of the Issuer is filed by the Issuer with the Trustee) to Summit Therapeutics plc, One Broadway, Cambridge, Massachusetts, 02142, Attn: Chief Financial Officer. Any notice, direction, request or demand by the
Issuer or any Holder of Securities to or upon the Trustee shall be deemed to have been sufficiently given or made, for all purposes, if given or made at             ,
            , Attn:             . 

Where this Indenture provides for notice to Holders of Securities, such notice shall be sufficiently given (unless otherwise herein expressly
provided) if in writing and mailed, first-class postage prepaid, to each Holder entitled thereto, at his or her last address as it appears in the Security register. In case, by reason of the suspension of or irregularities in regular mail service,
it shall be impracticable to mail notice of any event to Holders of Securities when said notice is required to be given pursuant to any provision of this Indenture or of the Securities, then any manner of giving such notice as shall be satisfactory
to the Trustee shall be deemed to be a sufficient giving of such notice. 
 In case, by reason of the suspension of or irregularities in
regular mail service, it shall be impracticable to mail notice to the Issuer when such notice is required to be given pursuant to any provision of this Indenture, then any manner of giving such notice as shall be satisfactory to the Trustee shall be
deemed to be a sufficient giving of such notice. 
 Neither the failure to give notice, nor any defect in any notice so given, to any
particular Holder of a Security shall affect the sufficiency of such notice with respect to other Holders of Securities given as provided above. 

  
 43 

 Where this Indenture provides for notice in any manner, such notice may be waived in writing by
the Person entitled to receive such notice either before or after the event, and such waiver shall be the equivalent of such notice. Waivers of notice by Holders shall be filed with the Trustee, but such filing shall not be a condition precedent to
the validity of any action taken in reliance upon such waiver. 
 Section 11.05 Officer’s Certificates and Opinions of Counsel;
Statements to Be Contained Therein. Upon any application or demand by the Issuer to the Trustee to take any action under any of the provisions of this Indenture, the Issuer shall furnish to the Trustee an Officer’s Certificate stating that
all conditions precedent provided for in this Indenture relating to the proposed action have been complied with and an Opinion of Counsel stating that in the opinion of such counsel all such conditions precedent have been complied with, except that
in the case of any such application or demand as to which the furnishing of such documents is specifically required by any provision of this Indenture relating to such particular application or demand, no additional certificate or opinion need be
furnished. 
 Each certificate or opinion provided for in this Indenture and delivered to the Trustee with respect to compliance with a
condition or covenant provided for in this Indenture shall include (a) a statement that the person making such certificate or opinion has read such covenant or condition, (b) a brief statement as to the nature and scope of the examination
or investigation upon which the statements or opinions contained in such certificate or opinion are based, (c) a statement that, in the opinion of such person, he or she has made such examination or investigation as is necessary to enable him
or her to express an informed opinion as to whether or not such covenant or condition has been complied with and (d) a statement as to whether or not, in the opinion of such person, such condition or covenant has been complied with. 

Any certificate, statement or opinion of an officer of the Issuer may be based, insofar as it relates to legal matters, upon a certificate or
opinion of or representations by counsel, unless such officer knows that the certificate or opinion or representations with respect to the matters upon which his or her certificate, statement or opinion may be based as aforesaid are erroneous, or in
the exercise of reasonable care should know that the same are erroneous. Any certificate, statement or opinion of counsel may be based, insofar as it relates to factual matters, information with respect to which is in the possession of the Issuer,
upon the certificate, statement or opinion of or representations by an officer or officers of the Issuer, unless such counsel knows that the certificate, statement or opinion or representations with respect to the matters upon which his or her
certificate, statement or opinion may be based as aforesaid are erroneous, or in the exercise of reasonable care should know that the same are erroneous. 

Any certificate, statement or opinion of an officer of the Issuer or of counsel may be based, insofar as it relates to accounting matters,
upon a certificate or opinion of or representations by an accountant or firm of accountants in the employ of the Issuer, unless such officer or counsel, as the case may be, knows that the certificate or opinion or representations with respect to the
accounting matters upon which his or her certificate, statement or opinion may be based as aforesaid are erroneous, or in the exercise of reasonable care should know that the same are erroneous. 

  
 44 

 Any certificate or opinion of any independent firm of public accountants filed with and directed
to the Trustee shall contain a statement that such firm is independent. 
 Section 11.06 Payments Due on Saturdays, Sundays and
Holidays. If the date of maturity of interest on or principal of the Securities of any series or the date fixed for redemption or repayment of any such Security, or the last day on which a Holder has the right to convert any Security, shall not
be a Business Day, then payment of interest or principal, or any conversion, need not be made on such date, but may be made on the next succeeding Business Day with the same force and effect as if made on the date of maturity or the date fixed for
redemption or on such last day for conversion, and no interest shall accrue for the period after such date. 
 Section 11.07
Conflict of Any Provision of Indenture With Trust Indenture Act of 1939. If and to the extent that any provision of this Indenture limits, qualifies or conflicts with another provision included in this Indenture by operation of Sections 310
to 317, inclusive, of the Trust Indenture Act of 1939, such incorporated provision shall control. 
 Section 11.08 New York Law to
Govern. This Indenture and each Security shall be deemed to be a contract under the laws of the State of New York, and for all purposes shall be governed by and construed in accordance with the laws of such State without regard to any principle
of conflict of laws that would require or permit the application of the laws of any other jurisdiction, except as may otherwise be required by mandatory provisions of law. 

Section 11.09 Counterparts. This Indenture may be executed in any number of counterparts, each of which shall be an original; but
such counterparts shall together constitute but one and the same instrument. 
 Section 11.10 Effect of Headings. The Article
and Section headings herein and the Table of Contents are for convenience only and shall not affect the construction hereof. 

Section 11.11 Actions by Successor. Any act or proceeding by any provision of this Indenture authorized or required to be done or
performed by any board of directors or its equivalent, committee or officer of the Issuer shall and may be done and performed with like force and effect by the corresponding board, committee or officer of any corporation that shall at the time be
the lawful successor of the Issuer. 
 Section 11.12 Severability. In case any one or more of the provisions contained in this
Indenture or in the Securities of any series shall for any reason be held to be invalid, illegal or unenforceable in any respect, such invalidity, illegality or unenforceability shall not affect any other provisions of this Indenture or of such
Securities, but this Indenture and such Securities shall be construed as if such invalid or illegal or unenforceable provision had never been contained herein or therein. 

ARTICLE 12 
 REDEMPTION OF
SECURITIES AND SINKING FUNDS 
 Section 12.01 Applicability of Article. The provisions of this Article shall be applicable to
the Securities of any series which are redeemable before their maturity or to any sinking fund for the retirement of Securities of a series, except as otherwise specified, as contemplated by Section 2.03 for Securities of such series. 

  
 45 

 Section 12.02 Notice of Redemption; Partial Redemptions. Notice of redemption to the
Holders of Securities of any series to be redeemed as a whole or in part at the option of the Issuer shall be given by mailing notice of such redemption by first class mail, postage prepaid, at least 30 days and not more than 60 days prior to the
date fixed for redemption to such Holders of Securities of such series at their last addresses as they shall appear upon the Security register. Any notice which is given in the manner herein provided shall be conclusively presumed to have been duly
given, whether or not the Holder receives the notice. Failure to give notice or any defect in the notice to the Holder of any Security of a series designated for redemption as a whole or in part shall not affect the validity of the proceedings for
the redemption of any other Security of such series. 
 The notice of redemption to each such Holder shall specify the principal amount of
each Security of such series held by such Holder to be redeemed, the date fixed for redemption, the redemption price, the place or places of payment, that payment will be made upon presentation and surrender of such Securities, that such redemption
is pursuant to the mandatory or optional sinking fund, or both, if such be the case, that interest accrued to the date fixed for redemption will be paid as specified in such notice and that on and after said date interest thereon or on the portions
thereof to be redeemed will cease to accrue and shall also specify, if applicable, the conversion price then in effect and the date on which the right to convert such Securities or the portions thereof to be redeemed will expire. In case any
Security of a series is to be redeemed in part only, the notice of redemption shall state the portion of the principal amount thereof to be redeemed and shall state that on and after the date fixed for redemption, upon surrender of such Security, a
new Security or Securities of such series in principal amount equal to the unredeemed portion thereof will be issued. 
 The notice of
redemption of Securities of any series to be redeemed at the option of the Issuer shall be given by the Issuer or, at the Issuer’s request, by the Trustee in the name and at the expense of the Issuer. 

On or before the redemption date specified in the notice of redemption given as provided in this Section, the Issuer will deposit with the
Trustee or with one or more paying agents (or, if the Issuer is acting as its own paying agent, set aside, segregate and hold in trust as provided in Section 3.04) an amount of money sufficient to redeem on the redemption date all the
Securities of such series so called for redemption (other than those Securities theretofore surrendered for conversion into Ordinary Shares in accordance with their terms) at the appropriate redemption price, together with accrued interest to the
date fixed for redemption. If any Security called for redemption is converted pursuant hereto and in accordance with the terms thereof, any money deposited with the Trustee or any paying agent or so segregated and held in trust for the redemption of
such Security shall be paid to the Issuer upon the Issuer’s request, or, if then held by the Issuer, shall be discharged from such trust. The Issuer will deliver to the Trustee at least 10 days prior to the date the notice required to be
delivered to the Holders is to be sent (unless a shorter time period shall be acceptable to the Trustee) an Officer’s Certificate (which need not comply with Section 11.05) stating the aggregate principal amount of Securities to be
redeemed. In case of a redemption at the election of the Issuer prior to the expiration of any restriction on such redemption, the Issuer shall deliver to the Trustee, prior to the giving of any notice of redemption to Holders pursuant to this
Section, an Officer’s Certificate stating that such restriction has been complied with. 

  
 46 

 If less than all the Securities of a series are to be redeemed, the Trustee shall select, in such
manner as it shall deem appropriate and fair, Securities of such series to be redeemed in whole or in part. Securities may be redeemed in part in multiples equal to the minimum authorized denomination for Securities of such series or any multiple
thereof. The Trustee shall promptly notify the Issuer in writing of the Securities of such series selected for redemption and, in the case of any Securities of such series selected for partial redemption, the principal amount thereof to be redeemed.
For all purposes of this Indenture, unless the context otherwise requires, all provisions relating to the redemption of Securities of any series shall relate, in the case of any Security redeemed or to be redeemed only in part, to the portion of the
principal amount of such Security which has been or is to be redeemed. If any Security selected for partial redemption is surrendered for conversion after such selection, the converted portion of such Security shall be deemed (so far as may be
possible) to be the portion selected for redemption. 
 Section 12.03 Payment of Securities Called for Redemption. If notice of
redemption has been given as above provided, the Securities or portions of Securities specified in such notice shall become due and payable on the date and at the place stated in such notice at the applicable redemption price, together with interest
accrued to the date fixed for redemption, and on and after said date (unless the Issuer shall default in the payment of such Securities at the redemption price, together with interest accrued to said date) interest on the Securities or portions of
Securities so called for redemption shall cease to accrue, and such Securities shall cease from and after the date fixed for redemption to be convertible into Ordinary Shares (to the extent otherwise convertible in accordance with their terms), if
applicable, and cease to be entitled to any benefit or security under this Indenture, and except as provided in the paragraph below, the Holders thereof shall have no right in respect of such Securities except the right to receive the redemption
price thereof and unpaid interest to the date fixed for redemption. On presentation and surrender of such Securities at a place of payment specified in said notice, said Securities or the specified portions thereof shall be paid and redeemed by the
Issuer at the applicable redemption price, together with interest accrued thereon to the date fixed for redemption; provided, that payment of interest becoming due on or prior to the date fixed for redemption shall be payable to the Holders
of such Securities registered as such on the relevant record date subject to the terms and provisions of Sections 2.03 and 2.07 hereof. 

If any Security called for redemption shall not be so paid upon surrender thereof for redemption, the principal shall, until paid or duly
provided for, bear interest from the date fixed for redemption at the rate of interest or Yield to Maturity (in the case of an Original Issue Discount Security) borne by such Security and, if applicable, such Security shall remain convertible into
Ordinary Shares until the principal of such Security shall have been paid or duly provided for. 
 Upon presentation of any Security
redeemed in part only, the Issuer shall execute and the Trustee shall authenticate and deliver to or on the order of the Holder thereof, at the expense of the Issuer, a new Security or Securities of such series, of authorized denominations, in
principal amount equal to the unredeemed portion of the Security so presented. 

  
 47 

 Section 12.04 Exclusion of Certain Securities from Eligibility for Selection for
Redemption. Securities shall be excluded from eligibility for selection for redemption if they are identified by registration and certificate number in an Officer’s Certificate delivered to the Trustee at least 40 days prior to the last
date on which notice of redemption may be given as being owned of record and beneficially by, and not pledged or hypothecated by either (a) the Issuer or (b) an entity specifically identified in such written statement as directly or
indirectly controlling or controlled by or under direct or indirect common control with the Issuer. 
 Section 12.05 Mandatory and
Optional Sinking Funds. The minimum amount of any sinking fund payment provided for by the terms of the Securities of any series is herein referred to as a “mandatory sinking fund payment”, and any payment in excess of such
minimum amount provided for by the terms of the Securities of any series is herein referred to as an “optional sinking fund payment”. The date on which a sinking fund payment is to be made is herein referred to as the
“sinking fund payment date”. 
 In lieu of making all or any part of any mandatory sinking fund payment with respect to any
series of Securities in cash, the Issuer may at its option (a) deliver to the Trustee Securities of such series theretofore purchased or otherwise acquired (except upon redemption pursuant to the mandatory sinking fund) by the Issuer or receive
credit for Securities of such series (not previously so credited) theretofore purchased or otherwise acquired (except as aforesaid) by the Issuer and delivered to the Trustee for cancellation pursuant to Section 2.10 and, if applicable, receive
credit for Securities (not previously so credited) converted into Ordinary Shares and so delivered to the Trustee for cancellation, (b) receive credit for optional sinking fund payments (not previously so credited) made pursuant to this
Section, or (c) receive credit for Securities of such series (not previously so credited) redeemed by the Issuer through any optional redemption provision contained in the terms of such series. Securities so delivered or credited shall be
received or credited by the Trustee at the sinking fund redemption price specified in such Securities. 
 On or before the 60th day next
preceding each sinking fund payment date for any series, the Issuer will deliver to the Trustee an Officer’s Certificate (which need not contain the statements required by Section 11.05) (a) specifying the portion of the mandatory
sinking fund payment to be satisfied by payment of cash and the portion to be satisfied by credit of Securities of such series and the basis for such credit, (b) stating that none of the Securities of such series for which credit will be taken
has theretofore been so credited, (c) stating that no defaults in the payment of interest or Events of Default with respect to such series have occurred (which have not been waived or cured) and are continuing and (d) stating whether or
not the Issuer intends to exercise its right to make an optional sinking fund payment with respect to such series and, if so, specifying the amount of such optional sinking fund payment which the Issuer intends to pay on or before the next
succeeding sinking fund payment date. Any Securities of such series to be credited and required to be delivered to the Trustee in order for the Issuer to be entitled to credit therefor as aforesaid which have not theretofore been delivered to the
Trustee shall be delivered for cancellation pursuant to Section 2.10 to the Trustee with such Officer’s Certificate (or reasonably promptly thereafter if acceptable to the Trustee). Such Officer’s Certificate shall be irrevocable and
upon its receipt by the Trustee the Issuer shall become unconditionally obligated to make all the cash payments or payments therein referred to, if any, on or before the next succeeding sinking fund payment date. Failure of the Issuer, on or before
any such 60th day, to deliver such Officer’s Certificate and Securities specified in this paragraph, if any, shall not constitute a default but shall constitute, on and as of such date, the irrevocable election of the Issuer that the mandatory
sinking fund payment for such series due on the next succeeding sinking fund payment date shall be paid entirely in cash without the option to deliver or credit Securities of such series in respect thereof. 

  
 48 

 If the sinking fund payment or payments (mandatory or optional or both) to be made in cash
on the next succeeding sinking fund payment date plus any unused balance of any preceding sinking fund payments made in cash shall exceed $50,000 (or the equivalent thereof in any Foreign Currency or a lesser sum in Dollars or in any Foreign
Currency if the Issuer shall so request) with respect to the Securities of any particular series, such cash shall be applied on the next succeeding sinking fund payment date to the redemption of Securities of such series at the sinking fund
redemption price together with accrued interest to the date fixed for redemption. If such amount shall be $50,000 (or the equivalent thereof in any Foreign Currency) or less and the Issuer makes no such request then it shall be carried over until a
sum in excess of $50,000 (or the equivalent thereof in any Foreign Currency) is available, which delay in accordance with this paragraph shall not be a default or breach of the obligation to make such payment. The Trustee shall select, in the manner
provided in Section 12.02, for redemption on such sinking fund payment date a sufficient principal amount of Securities of such series to which such cash may be applied, as nearly as may be, and shall (if requested in writing by the Issuer)
inform the Issuer of the serial numbers of the Securities of such series (or portions thereof) so selected. The Trustee, in the name and at the expense of the Issuer (or the Issuer, if it shall so request the Trustee in writing), shall cause notice
of redemption of the Securities of such series to be given in substantially the manner provided in Section 12.02 (and with the effect provided in Section 12.03) for the redemption of Securities of such series in part at the option of the
Issuer. The amount of any sinking fund payments not so applied or allocated to the redemption of Securities of such series shall be added to the next cash sinking fund payment for such series and, together with such payment, shall be applied in
accordance with the provisions of this Section. Any and all sinking fund moneys held on the stated maturity date of the Securities of any particular series (or earlier, if such maturity is accelerated), which are not held for the payment or
redemption of particular Securities of such series, shall be applied, together with other moneys, if necessary, sufficient for the purpose, to the payment of the principal of, and interest on, the Securities of such series at maturity. The
Issuer’s obligation to make a mandatory or optional sinking fund payment shall automatically be reduced by an amount equal to the sinking fund redemption price allocable to any Securities or portions thereof called for redemption pursuant to
the preceding paragraph on any sinking fund payment date and converted into Ordinary Shares in accordance with the terms of such Securities; provided that, if the Trustee is not the conversion agent for the Securities, the Issuer or such
conversion agent shall give the Trustee written notice on or prior to the date fixed for redemption of the principal amount of Securities or portions thereof so converted. 

  
 49 

 On or before each sinking fund payment date, the Issuer shall pay to the Trustee in cash or shall
otherwise provide for the payment of all interest accrued to the date fixed for redemption on Securities to be redeemed on such sinking fund payment date. 

The Trustee shall not redeem or cause to be redeemed any Securities of a series with sinking fund moneys or give any notice of redemption of
Securities for such series by operation of the sinking fund during the continuance of a default in payment of interest on such Securities or of any Event of Default except that, where the mailing of notice of redemption of any Securities shall
theretofore have been made, the Trustee shall redeem or cause to be redeemed such Securities, provided that it shall have received from the Issuer a sum sufficient for such redemption. Except as aforesaid, any moneys in the sinking fund for such
series at the time when any such default or Event of Default shall occur, and any moneys thereafter paid into the sinking fund, shall, during the continuance of such default or Event of Default, be deemed to have been collected under Article 5 and
held for the payment of all such Securities. In case such Event of Default shall have been waived as provided in Section 5.10, or the default cured on or before the 60th day preceding the sinking fund payment date in any year, such moneys shall
thereafter be applied on such sinking fund payment date in accordance with this Section to the redemption of such Securities. 

[Signature pages follow] 

  
 50 

 IN WITNESS WHEREOF, the parties hereto have caused this Indenture to be duly executed as of
            . 
  

			
	SUMMIT THERAPEUTICS PLC
		
	By:	 	 
		 	 Name:
 Title:

  

			
	Attest:
		
	By:	 	 
		 	 Name:
 Title:

  

			
	                        , Trustee
		
	By:	 	 
		 	 Name:
 Title:

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00258-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00258-of-00352.parquet"}]]