Document:

Assignment and Assumption Agreement, dated December 10, 2009

 Exhibit 10.12 
 Execution Version 
 ASSIGNMENT AND ASSUMPTION AGREEMENT 

This ASSIGNMENT AND ASSUMPTION AGREEMENT (this “Assignment Agreement”) by and between Quintiles Transnational Corp., a
North Carolina corporation (“Assignor”), and Quintiles Transnational Holdings Inc., a North Carolina corporation (“Assignee”), made and dated as of December 10, 2009. 

WHEREAS, Assignor and Assignee entered into an Agreement and Plan of Share Exchange, dated as of December 3, 2009 (the
“Agreement and Plan of Share Exchange”), pursuant to which each outstanding share of Assignor common stock will be exchanged for one share of common stock of Assignee (the “Share Exchange”), and Assignee will become
a holding company with Assignor as its wholly-owned subsidiary; 
 WHEREAS, in connection with the Share Exchange, Assignee will
assume the Assignor’s rights and obligations under the terms of certain outstanding agreements between Assignor and its shareholders that govern the rights and obligations of such parties with respect to the shares of Assignor’s common
stock subject to the Share Exchange (the “Stock Agreements”). Thus, any rights (and obligations) the Assignor’s shareholders have under the Stock Agreements will continue after the effective time of the Share Exchange and will
apply to the Assignee shares; 
 WHEREAS, in connection with the Share Exchange, Assignee will assume the Assignor’s rights
and obligations under the terms of certain outstanding agreements between Assignor and certain of its directors that govern the rights and obligations of such parties (the “Independent Director Indemnification Agreements”). As a
result, Asignee will perform under each of the Independent Director Indemnification Agreements in the same manner and to the same extent the Assignor would be required to perform if no Share Exchange had taken place; 

WHEREAS, in connection with the Share Exchange, Assignor and Assignee have determined that it is in the best interests of the parties
that Assignor assign and Assignee acquire all of Assignor’s right, title, and interest in and to each of the Stock Agreements set forth on Schedule A attached hereto (the “Assigned Stock Agreements”); and 

WHEREAS, in connection with the Share Exchange, Assignee is required by the terms of the Independent Director Indemnification Agreements
to assume each of the Independent Director Indemnification Agreements, and Asignor and Assignee have determined that it is in the best interest of the parties that Assignor assign and that Assignee acquire all of Assignor’s right, title, and
interest in and to each of the Independent Director Indemnification Agreements set forth on Schedule B attached hereto (the “Assigned Independent Director Indemnification Agreements” and collectively with the Assigned Stock
Agreements, the “Assigned Agreements”); 
 NOW, THEREFORE, for good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, Assignor does hereby sell, convey, assign, transfer and deliver unto Assignee (collectively, the “Assignment”) all of Assignor’s right, title, and interest in and to, and all of
Assignor’s obligations and liabilities in connection with, each of 

 
the Assigned Agreements, to be held and enjoyed by Assignee for its own use and benefit and for the use and benefit of its successors and assigns. 

Assignee hereby accepts the Assignment and assumes and agrees to be responsible for and to observe and perform all of the obligations,
terms, provisions, agreements and covenants, and to pay and discharge all of the liabilities and obligations of Assignor to be observed, performed, paid, or discharged in connection with the Assigned Agreements. 

This Assignment Agreement may be executed in any number of counterparts, each of which when executed and delivered shall be deemed to be
an original and all of which counterparts taken together shall constitute one and the same instrument. The exchange of copies of this Assignment Agreement and of executed signature pages by facsimile transmission or by email transmission in portable
document format (.pdf), or similar format, shall constitute effective execution and delivery of this Assignment Agreement. Signatures of the parties transmitted by facsimile, or by email in portable document or similar format, shall be deemed to be
their original signatures for all purposes. This Assignment Agreement may not be amended or modified (other than to change Schedule A to to capture the appropriate agreements with Assignor’s shareholders in effect immediately
prior to the Share Exchange) without the prior written agreement of both parties hereto. Notwithstanding anything contained herein to the contrary, this Assignment Agreement shall become effective at the effective time of the Share Exchange (as
contemplated by the Agreement and Plan of Share Exchange). In the event the Share Exchange is abandoned or the Agreement and Plan of Share Exchange terminated, this Assignment Agreement shall immediately be terminated without out future action by
the parties hereto and the Assignment contemplated hereby shall be null and void. 
 [signature page follows] 

 [Signature page to Assignment and Assumption Agreement] 

IN WITNESS WHEREOF, Assignor and Assignee have each caused this Assignment Agreement to be duly executed as of the date first above
written. 
  

			
	QUINTILES TRANSNATIONAL CORP.
		
	By:	 	 /s/ John Goodacre

	Name:	 	John Goodacre
	Title:	 	Corporate Secretary

  

			
	QUINTILES TRANSNATIONAL HOLDINGS INC.
		
	By:	 	 /s/ Beverly L. Rubin

	Name:	 	Beverly L. Rubin
	Title:	 	Secretary

 Schedule A 
 Assigned Stock Agreements 
 The table set forth below identifies the
Assigned Stock Agreements (identified by shareholder of Assignor (or “Quintiles”) and outstanding stock certificate number). Many agreements, such as the Shareholders Agreement dated 1/22/08 and the Amended and Restated Registration
Rights Agreement dated 1/22/08, have more than one shareholder party. In addition, various shareholders hold shares under multiple stock certificates that are subject to the same agreement. Thus, the table below includes multiple references to the
same agreement. 
 In addition to the agreements specifically identified below, the Assigned Stock Agreements include:

  

	 	•	 	 certain joinder letters or other transfer agreements executed by certain shareholders in connection with their initial acquisition of the shares
through “permitted” transfer(s) from existing shareholder(s); 

  

	 	•	 	 acceptance letters or subscription agreements entered into by shareholders who acquired restricted shares under Quintiles’ stock incentive plans
(whether by direct issuance or exercise of stock options); 

  

	 	•	 	 promissory notes or other documents governing any outstanding loans made by Quintiles (or its predecessor(s)) to certain employees in connection with
the purchase of shares by such employees. 

 This table does not specifically reference the assumption by Assignor of
Quintiles’ outstanding stock incentive plans which is addressed under separate board or committee action. 
 This table is based on the
books and records of Assignor as of December 3, 2009 and may be amended or modified to capture the appropriate agreements with Assignor’s shareholders in effect immediately prior to the Share Exchange without further action by the Assignor
or Assignee. 
  

									
	 	  	Outstanding Shares	 	  	 
	 Shareholder Name
	  	Cert.
No.	  	Number of
Shares	 	  	 Assigned Agreements

	 3i U.S. Growth Partners L.P.
	  	361	  	 	3,018,835.2259	  	  	 Shareholders Agreement dated 1/22/08

 
 Amended and Restated Registration Rights Agreement dated
1/22/08
  
 Management Rights Letter dated 1/22/08
(Affiliate as party)
  
 Transfer Restriction
Letter dated 12/20/07 (Affiliate as party)
  

Subscription Agreement dated 12/20/07

									
	 	  	Outstanding Shares	 	  	 
	 Shareholder Name
	  	Cert.
No.	  	Number of
Shares	 	  	 Assigned Agreements

	 3i U.S. Growth Partners L.P.
	  	364	  	 	5,144,430.0799	  	  	 Shareholders Agreement dated 1/22/08

 
 Amended and Restated Registration Rights Agreement dated
1/22/08
  
 Management Rights Letter dated 1/22/08
(Affiliate as party)
  
 Transfer Restriction
Letter dated 12/20/07 (Affiliate as party)
  

Stock Purchase Agreement dated 12/20/07

	 3i US Growth Healthcare Fund 2008 L.P.
	  	360	  	 	3,451,715.7741	  	  	 Shareholders Agreement dated 1/22/08

 
 Amended and Restated Registration Rights Agreement dated
1/22/08
  
 Management Rights Letter dated
1/22/08
  
 Transfer Restriction Letter dated
12/20/07
  
 Subscription Agreement dated
12/20/07

	 3i US Growth Healthcare Fund 2008 L.P.
	  	363	  	 	5,882,106.5498	  	  	 Shareholders Agreement dated 1/22/08

 
 Amended and Restated Registration Rights Agreement dated
1/22/08
  
 Management Rights Letter dated
1/22/08
  
 Transfer Restriction Letter dated
12/20/07
  
 Subscription Agreement dated
12/20/07

	 Aisling Capital II, L.P.
	  	356	  	 	1,836,734.6939	  	  	 Shareholders Agreement dated 1/22/08

 
 Amended and Restated Registration Rights Agreement dated
1/22/08
  
 Management Rights Letter dated
1/22/08

									
	 	  	Outstanding Shares	 	  	 
	 Shareholder Name
	  	Cert.
No.	  	Number of
Shares	 	  	 Assigned Agreements

		  		  				  	Stock Purchase Agreement dated 12/20/07
	 Bain Capital Integral Investors 2008, L.P.
	  	346	  	 	26,412,990.0500	  	  	 Shareholders Agreement dated 1/22/08

 
 Amended and Restated Registration Rights Agreement dated
1/22/08
  
 Stock Purchase Agreement dated
12/20/07

	 BCIP Associates – G
	  	348	  	 	3,702.2400	  	  	 Shareholders Agreement dated 1/22/08

 
 Amended and Restated Registration Rights Agreement dated
1/22/08
  
 Stock Purchase Agreement dated
12/20/07

	 BCIP TCV, LLC
	  	347	  	 	64,967.7100	  	  	 Shareholders Agreement dated 1/22/08

 
 Amended and Restated Registration Rights Agreement dated
1/22/08
  
 Stock Purchase Agreement dated
12/20/07

	 Brown, Ernest Gerald
	  	84	  	 	44,790.8301	  	  	Letter Agreement dated 03/01/04
	 Casey, Paul
	  	62	  	 	13,023.0049	  	  	Rollover Agreement dated 9/19/03
	 Corken, Gillian
	  	399	  	 	290,856.7473	  	  	Rollover Agreement dated 09/22/03
	 DeCherney, G. Stephen
	  	537	  	 	80,000.0000	  	  	Agreement & General Release dated 3/2008
	 Douglass Family Limited Partnership
	  	376	  	 	161,888.6751	  	  	Rollover Agreement dated 9/16/03
	 Douglass, Chester W.
	  	519	  	 	232,778.0705	  	  	Rollover Agreement dated 9/16/03
	 Douglass, Jenny and Andrew Henry Basnight, jointly
	  	227	  	 	18,600.0000	  	  	Rollover Agreement dated 9/16/03
	 Douglass, Joy A.
	  	79	  	 	5,947.4979	  	  	Rollover Agreement dated 9/16/03
	 Douglass, Joy A.
	  	506	  	 	40,000.0000	  	  	Rollover Agreement dated 9/16/03

									
	 	  	Outstanding Shares	 	  	 
	 Shareholder Name
	  	Cert.
No.	  	Number of
Shares	 	  	 Assigned Agreements

	 Douglass, Joy A.
	  	518	  	 	54,000.0000	  	  	Rollover Agreement dated 9/16/03
	 Douglass, R. Anthony
	  	378	  	 	16,000.0000	  	  	Rollover Agreement dated 9/16/03
	 GF Investment Associates LP
	  	16	  	 	2,930,485.0000	  	  	 Shareholders Agreement dated 1/22/08

 
 Rollover Agreement dated 8/28/09

 
 Amended and Restated Registration Rights Agreement dated
1/22/08

	 GFEF Limited Partnership
	  	14	  	 	42,227.2354	  	  	 Shareholders Agreement dated 1/22/08

 
 Rollover Agreement dated 8/28/03

 
 Amended and Restated Registration Rights Agreement dated
1/22/08

	 Gillings Family Foundation, The
	  	12	  	 	163,556.1936	  	  	 Shareholders Agreement dated 1/22/08

 
 Rollover Agreement dated 8/28/03

 
 Amended and Restated Registration Rights Agreement dated
1/22/08

	 Gillings Family Limited Partnership
	  	13	  	 	713,699.7539	  	  	 Shareholders Agreement dated 1/22/08

 
 Rollover Agreement dated 8/28/03

 
 Amended and Restated Registration Rights Agreement dated
1/22/08

	 Gillings, Dennis B., CBE
	  	329	  	 	21,076.0000	  	  	 Shareholders Agreement dated 1/22/08

 
 Amended and Restated Registration Rights Agreement dated
1/22/08
  
 Restricted Stock Purchase Agreement
dated 9/25/03

	 Gillings, Dennis B., CBE
	  	333	  	 	994,861.9910	  	  	 Shareholders Agreement dated 1/22/08

 
 Amended and Restated Registration Rights Agreement dated
1/22/08
  
 Rollover Agreement dated
8/28/03

									
	 	  	Outstanding Shares	 	  	 
	 Shareholder Name
	  	Cert.
No.	  	Number of
Shares	 	  	 Assigned Agreements

	 Gillings, Dennis B., CBE
	  	343	  	 	80,000.0000	  	  	 Shareholders Agreement dated 1/22/08

 
 Amended and Restated Registration Rights Agreement dated
1/22/08
  
 Restricted Stock Purchase Agreement
dated 9/25/03

	 Gillings, Dennis B., CBE
	  	345	  	 	1,436,806.6461	  	  	 Shareholders Agreement dated 1/22/08

 
 Amended and Restated Registration Rights Agreement dated
1/22/08
  
 Stock Purchase Agreement dated
12/20/07

	 Gillings, Dennis B., Ph.D.
	  	3	  	 	13,082,084.8318	  	  	 Shareholders Agreement dated 1/22/08

 
 Amended and Restated Registration Rights Agreement dated
1/22/08
  
 Rollover Agreement dated
8/28/03

	 Gillings, Dennis B., Ph.D.
	  	4	  	 	5,720,665.2743	  	  	 Shareholders Agreement dated 1/22/08

 
 Amended and Restated Registration Rights Agreement dated
1/22/08
  
 Restricted Stock Purchase Agreement
dated 9/25/03

	 Gillings, Dennis B., Ph.D.
	  	5	  	 	5,138.0090	  	  	 Shareholders Agreement dated 1/22/08

 
 Amended and Restated Registration Rights Agreement dated
1/22/08
  
 Rollover Agreement dated
8/28/03

	 Gillings, Dennis B., Ph.D.
	  	177	  	 	480,352.6456	  	  	 Shareholders Agreement dated 1/22/08

 
 Amended and Restated Registration Rights Agreement dated
1/22/08
  
 Rollover Agreement dated
8/28/03

									
	 	  	Outstanding Shares	 	  	 
	 Shareholder Name
	  	Cert.
No.	  	Number of
Shares	 	  	 Assigned Agreements

	 Gillings, Joan H.
	  	9	  	 	767,459.1879	  	  	 Shareholders Agreement dated 1/22/08

 
 Amended and Restated Registration Rights Agreement dated
1/22/08
  
 Rollover Agreement dated
8/28/03

	 Gillings, Joan H.
	  	178	  	 	3,568.4988	  	  	 Shareholders Agreement dated 1/22/08

 
 Amended and Restated Registration Rights Agreement dated
1/22/08
  
 Rollover Agreement dated
8/28/03

	 Greeff, Oppel, Family Trust, The
	  	233	  	 	362,709.4510	  	  	Rollover Agreement dated 9/25/03
	 Gross, Susan Gillings
	  	528	  	 	39,678.7326	  	  	 Shareholders Agreement dated 1/22/08

 
 Amended and Restated Registration Rights Agreement dated
1/22/08
  
 Rollover Agreement dated
8/28/03

	 Huemmer, John Matthew & Melissa K. Huemmer JTWROS
	  	368	  	 	38,570.4814	  	  	Rollover Agreement dated 9/16/03
	 Huemmer, Melissa K.
	  	340	  	 	12,427.1619	  	  	Rollover Agreement dated 9/16/03
	 Huemmer, Melissa K.
	  	369	  	 	11,593.8478	  	  	Rollover Agreement dated 9/16/03
	 Huemmer, Melissa K., CUST Jacob N. Huemmer UNIF TRAN MIN ACT NC
	  	69	  	 	11,568.4988	  	  	Rollover Agreement dated 9/16/03
	 Huemmer, Melissa K., CUST Joshua D. Huemmer UNIF TRAN MIN ACT NC
	  	68	  	 	12,757.9984	  	  	Rollover Agreement dated 9/16/03
	 Huemmer, Melissa K., CUST Justin Grove Huemmer UNIF TRAN MIN ACT NC
	  	70	  	 	10,280.5136	  	  	Rollover Agreement dated 9/16/03
	 Koch, Carolyn J. Koch
	  	532	  	 	43,322.0000	  	  	Rollover Agreement dated 9/16/03
	 Koch, Gary Grove
	  	531	  	 	18,322.0000	  	  	Rollover Agreement dated 9/16/03
	 Koch, Gary Grove, TTEE U/A DTD 11/24/99 Gary Grove Koch Trust
	  	372	  	 	54,000.0000	  	  	Rollover Agreement dated 9/16/03

									
	 	  	Outstanding Shares	 	  	 
	 Shareholder Name
	  	Cert.
No.	  	Number of
Shares	 	  	 Assigned Agreements

	 Koch, Jason G.
	  	342	  	 	12,427.1618	  	  	Rollover Agreement dated 9/16/03
	 Koch, Jason G.
	  	533	  	 	53,554.8454	  	  	Rollover Agreement dated 9/16/03
	 Koch, Jason G., as custodian for Griffin Grove Koch under Nevada’s Uniform Act on Transfers to Minors
	  	336	  	 	1,467.0000	  	  	Rollover Agreement dated 9/16/03
	 Koch, Jason G., as custodian for Griffin Grove Koch under Nevada’s Uniform Act on Transfers to Minors
	  	501	  	 	1,956.0000	  	  	Rollover Agreement dated 9/16/03
	 Koch, Jason G., as custodian for Griffin Grove Koch under Nevada’s Uniform Act on Transfers to Minors
	  	530	  	 	1,678.0000	  	  	Rollover Agreement dated 9/16/03
	 Koch, Jason G., as custodian for Hadley Quinn Koch under Nevada’s Uniform Act on Transfers to Minors
	  	523	  	 	1,956.0000	  	  	Rollover Agreement dated 9/16/03
	 Koch, Jason G., as custodian for Hadley Quinn Koch under Nevada’s Uniform Act on Transfers to Minors
	  	529	  	 	1,678.0000	  	  	Rollover Agreement dated 9/16/03
	 Koch, Jennifer
	  	341	  	 	12,427.1619	  	  	Rollover Agreement dated 9/16/03
	 Koch, Jennifer
	  	373	  	 	69,959.8453	  	  	Rollover Agreement dated 9/16/03
	 Koch, Nicole
	  	534	  	 	3,044.0000	  	  	Rollover Agreement dated 9/16/03
	 Koch, Tad H.
	  	73	  	 	6,542.2477	  	  	Rollover Agreement dated 9/16/03
	 Perseus-Soros BioPharmaceutical Fund, LP
	  	357	  	 	413,202.3064	  	  	 Shareholders Agreement dated 1/22/08

 
 Amended and Restated Registration Rights Agreement dated
1/22/08
  
 Subscription Agreement dated
9/17/03

	 Roberts, Cynthia M.
	  	344	  	 	200,012.0000	  	  	 Shareholders Agreement dated 1/22/08

 
 transferred under Restricted Stock Purchase Agreement
dated 9/25/03

	 Russell, John S.
	  	511	  	 	45,000.0000	  	  	Agreement & General Release dated 12/31/07

									
	 	  	Outstanding Shares	 	  	 
	 Shareholder Name
	  	Cert.
No.	  	Number of
Shares	 	  	 Assigned Agreements

	 Russell, Sallie Shuping
	  	512	  	 	45,000.0000	  	  	Agreement & General Release dated 12/31/07
	 Selisker, Rachel
	  	238	  	 	42,376.2346	  	  	Rollover Agreement dated 9/22/03
	 Smith Barney IRA FBO Gary G. Koch
	  	375	  	 	140,000.0000	  	  	Rollover Agreement dated 9/16/03
	 Stephenson, Dimitrie Hugo
	  	480	  	 	70,310.5816	  	  	Rollover Agreement dated 09/22/03
	 Temasek Life Sciences Private Limited
	  	362	  	 	11,271,069.0249	  	  	 Shareholders Agreement dated 1/22/08

 
 Amended and Restated Registration Rights Agreement dated
1/22/08
  
 Equity Commitment Letter dated
08/28/03 (Affiliate as party)
  
 Subscription
Agreement dated 8/28/03

	 TPG Quintiles Holdco II LLC
	  	367	  	 	400,000.0000	  	  	 Shareholders Agreement dated 1/22/08

 
 Amended and Restated Registration Rights Agreement dated
1/22/08
  
 Management Rights Letter dated 1/22/08
(Affiliate as party)
  
 Transfer Restriction
Letter dated 1/22/08 (Affiliate as party)
  

Assignment Agreement dated 1/22/08 from Affiliate party to Subscription Agreement dated 12/20/07

	 TPG Quintiles Holdco II LLC
	  	513	  	 	16,901,294.8415	  	  	 Shareholders Agreement dated 1/22/08

 
 Amended and Restated Registration Rights Agreement dated
1/22/08
  
 Management Rights Letter dated 1/22/08
(Affiliate as party)
  
 Transfer Restriction
Letter dated 1/22/08 (Affiliate as party)
  

Assignment Agreement dated 1/22/08 from Affiliate that is party to
Stock

									
	 	  	Outstanding Shares	 	  	 
	 Shareholder Name
	  	Cert.
No.	  	Number of
Shares	 	  	 Assigned Agreements

		  		  				  	Purchase Agreement dated 12/20/07
	 TPG Quintiles Holdco III LLC
	  	366	  	 	816,326.5306	  	  	 Shareholders Agreement dated 1/22/08

 
 Amended and Restated Registration Rights Agreement dated
1/22/08
  
 Management Rights Letter dated 1/22/08
(Affiliate as party)
  
 Transfer Restriction
Letter dated 1/22/08 (Affiliate as party)
  

Assignment Agreement dated 1/22/08 from Affiliate that is party to Stock Purchase Agreement dated 12/20/07

	 TPG Quintiles Holdco IV LLC
	  	514	  	 	100,000.0000	  	  	 Shareholders Agreement dated 1/22/08

 
 Amended and Restated Registration Rights Agreement dated
1/22/08
  
 Management Rights Letter dated 1/22/08
(Affiliate as party)
  
 Transfer Restriction
Letter dated 1/22/08 (Affiliate as party)
  

Assignment Agreement dated 1/22/08 from Affiliate party to Subscription Agreement dated
12/20/07

									
	 	  	Outstanding Shares	 	  	 
	 Shareholder Name
	  	Cert.
No.	  	Number of
Shares	 	  	 Assigned Agreements

	 TPG Quintiles Holdco LLC
	  	358	  	 	8,264,038.6279	  	  	 Shareholders Agreement dated 1/22/08

 
 Amended and Restated Registration Rights Agreement dated
1/22/08
  
 Management Rights Letter dated 1/22/08
(Affiliate as party)
  
 Equity Commitment Letter
dated 8/28/03 (Affiliate as party)
  

Subscription Agreement dated 8/28/03

	 Wilson, Michael
	  	234	  	 	63,686.0016	  	  	Rollover Agreement dated 9/19/03
	 Wilson, Michael
	  	491	  	 	26,525.8409	  	  	Subscription Agreement dated 09/18/03

 Schedule B 
 Assigned Independent Director Indemnification Agreements 
  

	1.	Independent Director Indemnification Agreement by and between Quintiles Transnational Corp. and Jack M. Greenberg 

 

	2.	Independent Director Indemnification Agreement by and between Quintiles Transnational Corp. and Leonard SchaefferQuintiles Transnational Holdings Inc. 2003 Stock Incentive Plan

 Exhibit 10.14 
 QUINTILES TRANSNATIONAL HOLDINGS INC. 
 2003 STOCK INCENTIVE PLAN

  

	Section 1.	Purpose 

 The Plan authorizes the
Committee to provide Employees, who are in a position to contribute to the long-term success of the Company or its subsidiaries, with Shares or Options to acquire Shares in the Company. The Company believes that this incentive program will cause
those persons to increase their interest in the welfare of the Company and its subsidiaries, and aid in attracting, retaining and motivating Employees of outstanding ability. 

 

	Section 2.	Definitions 

 Capitalized terms
not otherwise defined herein shall have the meanings set forth in this Section. 
 (a) “Affiliate” means, with respect
to any Person, any other Person that controls, is controlled by or is under common control with such Person. For the purposes of this definition, “control” (including, with its correlative meanings, the terms “controlled by” and
“under common control with”), as used with respect to any Person, shall mean the possession, directly or indirectly, of the power to direct or cause the direction of the management and policies of such Person, whether through the ownership
of securities, by contract or otherwise. 
 (b) “Board” shall mean the Board of Directors of the Company. 

(c) “Cause” shall have the meaning ascribed thereto in any employment agreement between the Company or any of its subsidiaries
and the Grantee, or, if there is no employment agreement or if any such employment agreement does not contain a definition of “cause”, then Cause shall mean a finding by the Committee that the Grantee has (i) been charged with a
felony or a crime involving moral turpitude, (ii) committed an act of fraud or embezzlement against the Company or its subsidiaries, (iii) materially violated any policy of the Company or its subsidiaries, (iv) failed, refused or
neglected to substantially perform his duties (other than by reason of a physical or mental impairment) or to implement the directives of the Company, or (v) willfully engaged in conduct that is materially injurious to the Company, monetarily
or otherwise. 
 (d) “Company” shall mean Quintiles Transnational Holdings Inc., a corporation organized under the
laws of the state of North Carolina. 
 (e) “Committee” shall mean the committee of the Board designated by the Board
to administer the Plan, or in the absence of any such designation, the Board. 
 (f) “Effective Date” shall have the
meaning set forth in Section 11. 

 (g) “Employee” shall mean any person that is providing, or has agreed to provide,
services to the Company or a subsidiary of the Company, whether as an employee, director or independent contractor. 
 (h)
“Fair Market Value” of a Share on any given date shall be determined in good faith by the Committee, taking into account such factors as the Committee determines are appropriate. 

(i) “Grant Certificate” shall mean a certificate accepted by the Grantee, or other written agreement between the Company and
the Grantee, evidencing the grant of an Option or Shares hereunder and containing such terms and conditions, not inconsistent with the Plan, as the Committee shall approve. 
 (j) “Grantee” shall mean an Employee granted an Option or Shares under the Plan. 
 (k) “ISO” shall mean any Option or portion thereof that is designated in a Grant Certificate as an ISO and meets the requirements of an incentive stock option under Section 422 of the
Internal Revenue Code of 1986. 
 (l) “Majority Common Shareholders” shall have the same meaning as such term is
defined in the Shareholders Agreement, or, if not so defined, the Shareholders (as such term is defined in the Shareholders Agreement) holding at least a majority of the aggregate Shares then outstanding and held by the Shareholders. 

(m) “Nonqualified Option” shall mean any Option or portion thereof that either is designated by the Committee as such or is
otherwise not an ISO. 
 (n) “Options” shall refer to options issued under and subject to the Plan. 

(o) “Permitted Transferee” means with respect to any Grantee (A) the spouse, any lineal ancestor or descendant (including
by adoption and stepchildren) of such Grantee or any of their spouses, lineal ancestors or descendants or any trust of which such Grantee or any Permitted Transferees of such Grantee (x) are the controlling trustees or (y) have the power
to remove the controlling trustees and appoint successor controlling trustees and which is established primarily for the benefit of any of the foregoing individuals; provided, that any Transfer to a trust described in subclause (y) must be
approved by a majority of the Committee, (B) the estate of any of the foregoing individuals established by reason of such individual’s death or any beneficiaries of such estate, or (C) any corporation, limited liability company or
partnership or any of their respective Permitted Transferees, all of the interests of which are (or is) owned by one or more of the Persons identified in this definition or any of their respective Permitted Transferees. 

(p) “Person” means an individual, partnership, corporation, limited liability company or partnership, trust, unincorporated
organization, joint venture, government (or agency or political subdivision thereof) or any other entity of any kind. 

  
 2 

 (q) “Plan” shall mean the Quintiles Transnational Holdings Inc. 2003 Stock
Incentive Plan as set forth herein and as amended from time to time. 
 (r) “Qualifying Offering” means the
consummation of an underwritten public offering of Shares registered under the Securities Act of 1933 that together with the consummation of any other prior underwritten public offerings of Shares registered under the Securities Act of 1933 results
in gross proceeds to the Company of at least $100 million in the aggregate. 
 (s) “Restrictive Covenant” shall mean
any agreement made by the Grantee with the Company or its subsidiaries relating to nondisclosure of confidential information or trade secrets, noncompetition, or nonsoliciation of clients or employees. 

(t) “Sale of the Company” shall mean the sale of the Company (whether by merger, consolidation, recapitalization,
reorganization, sale of securities, sale of assets or otherwise) in one transaction or series of related transactions to a Person or Persons pursuant to which such Person or Persons (together with its Affiliates) acquires (i) securities
representing at least 75% of the voting power of all securities of the Company, assuming the conversion, exchange or exercise of all securities convertible, exchangeable or exercisable for or into voting securities, or (ii) all or substantially
all of the Company’s assets on a consolidated basis; provided that for purposes of Section 9, such a sale to a Person that is a shareholder of the Company or a Permitted Transferee of any shareholder shall not be a Sale of the Company.

 (u) “Share” shall mean a share of the Company’s common stock, par value $.01. 

(v) “Shareholders Agreement” means any shareholders agreement that may be in effect from time to time among the Company and the
holders of a majority of its then outstanding Shares. 
 (w) “Unvested Shares” shall have the meaning set forth in
Section 6. 
 (x) “Vested Shares” shall have the meaning set forth in Section 6. 

 

	Section 3.	Shares Available under the Plan 

The total number of Shares that may be issued under the Plan shall not exceed 14,227,208, provided that Shares reacquired by the Company
pursuant to Section 8(c) at a price less than the Fair Market Value thereof shall again be available for issuance under the Plan. 

  
 3 

	Section 4.	Administration of the Plan 

 (a)
Authority of the Committee. The Plan shall be administered by the Committee. The Committee shall have full and final authority to take the following actions, in each case subject to and consistent with the provisions of the Plan: 

(i) to select the Employees to whom Options and Shares may be granted, and the number of Shares relating thereto; 

(ii) to determine the terms and conditions of any Option granted under the Plan, including the exercise price, conditions relating to
exercise, and termination of the right to exercise; 
 (iii) to determine whether Shares issued under the Plan shall be
Unvested Shares or Vested Shares, and the conditions pursuant to which Unvested Shares shall become Vested Shares; 
 (iv) to
suspend the vesting of Options or Unvested Shares granted on or after November 9, 2006, in the event the Grantee of such awards takes an approved leave of absence of six (6) months or more, as determined by the Committee in its sole
discretion, provided that such suspension is not otherwise prohibited by applicable law; 
 (v) to determine whether any Option
shall be an ISO or a Nonqualified Option; 
 (vi) to determine the restrictions or conditions related to the exercise of
Options and the delivery, holding and disposition of Shares issued under the Plan, including to require any Grantee or Permitted Transferee to make such representations, furnish such information and comply with or be subject to such other conditions
as it may consider appropriate in connection with the issuance or delivery of Shares or payment of other benefits in compliance with applicable laws, rules, and regulations, listing requirements, or other obligations; 

(vii) to prescribe the form of each Grant Certificate; 
 (viii) to adopt, amend, suspend, waive and rescind such rules and regulations and appoint such agents as the Committee may deem necessary or advisable to administer the Plan; 

(ix) to correct any defect or supply any omission or reconcile any inconsistency in the Plan and to construe and interpret the Plan and
any Grant Certificate or other instrument hereunder; and 
 (x) to make all other decisions and determinations as may be
required under the terms of the Plan or as the Committee may deem necessary or advisable for the administration of the Plan. 

  
 4 

 (b) Manner of Exercise of Committee Authority. Any action of the Committee with respect to
the Plan shall be final, conclusive and binding on all persons, including the Company, subsidiaries of the Company, Grantees, or any person claiming any rights under the Plan from or through any Grantee. If not specified in the Plan, the time at
which the Committee must or may make any determination shall be determined by the Committee, and any such determination may thereafter be modified by the Committee (subject to Section 11). The express grant of any specific power to the
Committee, and the taking of any action by the Committee, shall not be construed as limiting any power or authority of the Committee. The Committee may delegate to officers or managers of the Company or any subsidiary of the Company the authority,
subject to such terms as the Committee shall determine, to perform such functions as the Committee may determine, to the extent permitted under applicable law. 
 (c) Limitation of Liability. The Committee shall be entitled to, in good faith, rely or act upon any report or other information furnished to it by any officer or other employee of the Company or any of
its subsidiaries, the Company’s independent certified public accountants or any executive compensation consultant, legal counsel or other professional retained by the Company to assist in the administration of the Plan. To the fullest extent
permitted by applicable law, neither any member of the Committee, nor any officer or employee of the Company acting on its behalf, shall be personally liable for any action, determination or interpretation taken or made in good faith with respect to
the Plan, and each member of the Committee and any officer or employee of the Company acting on its behalf shall, to the extent permitted by law, be fully indemnified and protected by the Company with respect to any such action, determination or
interpretation. 
  

	Section 5.	Terms Relating to Options. 

 (a)
Generally. Options granted under the Plan shall be subject to the terms of the Plan and such other terms as the Committee shall set forth in a Grant Certificate. 
 (b) Termination of Options. Except as provided in a Grant Certificate, upon the Grantee’s termination of employment with the Company and its subsidiaries for any reason, (i) Options that are not
then vested and exercisable shall immediately terminate, and (ii) Options that are vested and exercisable shall generally remain exercisable until, and terminate upon, the 91st day following such termination of employment (or the 366th day
following such termination where such termination is by reason of death, or a disability, retirement or redundancy that is approved by the Committee for purposes of hereof); provided, however, that if such termination is for Cause or following such
termination the Grantee violates a Restrictive Covenant, all Options will terminate immediately; provided, further, that in any event, each Option will terminate upon the tenth anniversary of the date of grant, or such earlier time as may be
provided by action of the Committee pursuant to Section 7. 
 (c) Exercise of Options. Only the vested portion of any
Option may be exercised. A Grantee shall exercise an Option by delivery of written notice to the Company setting forth the number of Shares with respect to which the Option is to be exercised, together with a certified check or bank draft payable to
the order of the Company for an amount equal to the sum of the exercise price for such Shares and any employment tax required to be withheld. 

  
 5 

 
The Committee may, in its sole discretion, permit other forms of payment, including notes or other contractual obligations of a Grantee to make payment on a deferred basis. Before the Company
issues any Shares to a Grantee pursuant to the exercise of an Option, the Company shall have the right to require that the Grantee make such provision, or furnish the Company such authorization, as may be necessary or desirable so that the Company
may satisfy its obligation under applicable income tax laws to withhold for income or other taxes due upon or incident to such exercise. The Committee, may, in its discretion, permit such withholding obligation to be satisfied through the
withholding of Shares that would otherwise be delivered upon exercise of the Option. Unless otherwise provided in a Grant Certificate, Shares acquired upon exercise of an Option shall be Vested Shares. 

(d) Transferability. No Option may be sold, transferred, assigned, pledged or otherwise encumbered, and an Option shall be exercisable
only by the Grantee, provided that the Committee may permit transfers to a Permitted Transferee. Any such Permitted Transferee shall be subject to all the terms and conditions of the Plan and Grant Certificate, including the provisions relating to
the termination of the right to exercise the Option. 
 (e) Shares. Shares issued upon exercise of Options shall be treated as
Shares issued under the Plan for all purposes of the Plan, including the provisions of Section 3 and Section 8, and, unless otherwise provided in a Grant Certificate, Shares issued upon exercise of an Option shall be treated as Vested
Shares for purposes Section 8. 
 (f) Exercise Price. The exercise price (or the base value from which appreciation is to
be measured) of each Option shall be 100% (or in the case of an ISO granted to a ten percent shareholder within the meaning of subsection (b)(6) of Section 422 of the Internal Revenue Code of 1986, 110%) of the Fair Market Value of the Shares
subject to the Option determined as of the date of grant, or such higher amount as the Committee may determine in connection with the grant. Fair Market Value shall be determined by the Committee consistent with the applicable requirements of
Section 422 and Section 409A of the Internal Revenue Code of 1986. 
  

	Section 6.	Terms Relating to Awards of Shares. 

 The Committee may award Shares to a Grantee that may or may not be conditional upon the passage of time, the Grantee’s future performance of services and/or achievement of specified performance
targets. Shares granted under the Plan that are so conditional are referred to as “Unvested Shares”, and Shares that are not so conditional are referred to as “Vested Shares”. Except to the extent restricted under the terms of
the Plan and any Grant Certificate, a Grantee awarded Unvested Shares shall have all of the rights of a shareholder including, without limitation, the right to vote Unvested Shares or the right to receive dividends thereon. The Committee may require
the Grantee to pay (in cash or such other form as determined by the Committee, including notes or other contractual obligations of a Grantee to make payment on a deferred basis) for Shares at a price per Share up to the Fair Market Value thereof.
The grant of Shares or the lapse of restrictions on Unvested Shares shall be conditional on the Grantee’s satisfaction of any withholding tax obligation that arises in connection therewith. 

  
 6 

	Section 7.	Adjustment Upon Changes in Capitalization 

 In the event any recapitalization, forward or reverse split, reorganization, merger, consolidation, incorporation, spin-off, combination, repurchase, exchange of Shares or other securities, dividend or
distribution of Shares or other special and nonrecurring dividend or distribution (other than cash dividends or distributions), liquidation, dissolution, sale or purchase of assets or other similar transactions or events, affects the Shares such
that an adjustment is determined by the Committee to be appropriate in order to prevent dilution or enlargement of the rights of Grantees under the Plan, then the Committee shall equitably adjust any or all of (i) the number and kind of
securities deemed to be available thereafter for grants of awards under Section 3, (ii) the number and kind of securities subject to Unvested Shares or outstanding Options, and (iii) the exercise price per Share subject to Options. In
addition, the Committee is authorized to make adjustments in the terms and conditions of, and the criteria included in, Unvested Shares or Options (including, without limitation, acceleration of the expiration date of Options, cancellation of
Options in exchange for the intrinsic (i.e., in-the-money) value, if any, of the vested portion thereof, substitution of Unvested Shares or Options using securities or other obligations of a successor or other entity, or payment of a bonus or
dividend equivalent) in recognition of unusual or nonrecurring events (including, without limitation, a Sale of the Company, an event described in the preceding sentence or a cash dividend or distribution) affecting the Company or any subsidiary of
the Company or the financial statements of the Company or any subsidiary of the Company, or in response to changes in applicable laws, regulations, or accounting principles. 

 

	Section 8.	Restrictions on Shares. 

 (a)
Restrictions on Issuing Shares. No Shares shall be issued or transferred to an Employee under the Plan unless and until all applicable legal requirements have been complied with to the satisfaction of the Committee. The Committee shall have the
right to condition the award or delivery of Shares or exercise of any Option on the Grantee’s undertaking in writing to comply with such restrictions on any subsequent disposition of the Shares issued or transferred thereunder as the Committee
shall deem necessary or advisable as a result of any applicable law, regulation, official interpretation thereof, or any underwriting agreement. 
 (b) Transfer Restrictions. Except for transfers made in connection with a Sale of the Company, to the Company itself, or pursuant to Section 8(c) or (d) below, Shares issued to a Grantee
pursuant to the Plan may not be sold, pledged, encumbered or otherwise transferred other than to a Permitted Transferee. Any such Permitted Transferee shall be subject to all the terms and conditions of the Plan and Grant Certificate, including the
provisions of this Section 8. 
 (c) Repurchase Right. 

(i) Unless otherwise provided in a Grant Certificate, the Company shall have the right (but not the obligation) to repurchase any or all
of the Shares issued pursuant to the Plan upon a Grantee’s termination of employment with the Company and its subsidiaries for any reason. Such right shall be exercisable by the Company during the one-year period following the later of the date
of termination or the date the Grantee acquires the Shares, or such 

  
 7 

 
longer period as may be necessary so that the exercise of such right does not give rise to a compensation expense under applicable accounting rules. 

(ii) Unless otherwise provided in a Grant Certificate, the price per Share to be paid by the Company should it choose to exercise its
repurchase right shall equal, in the case of Unvested Shares, the price per Share paid by the Grantee (if any), and shall equal, in the case of Vested Shares, the Fair Market Value per Share; provided, however, that the price per Share to be paid by
the Company for any Vested Shares shall not exceed the price per Share paid by the Grantee (if any) if the Shares are to be repurchased following (x) the Grantee’s termination for Cause or (y) a breach by the Grantee of any
Restrictive Covenant. 
 (iii) The price per Share to be paid by the Company should it choose to exercise its repurchase right
shall be paid by in cash or plain check against delivery of certificates representing the repurchased Shares. Notwithstanding the foregoing, if at the time of the exercise of the repurchase right or payment for the Shares pursuant thereto, such
exercise or repurchase would result in a default or breach on the part of the Company or any subsidiary under any loan or other agreement, or if the repurchase would not be permitted under the North Carolina Business Corporation Act, then the
Company shall take possession of the Shares to be repurchased and payment shall be deferred until the first business day that it may occur without any such event existing or resulting. The Company may offset against the payment of the repurchase
price any amounts owed by the Grantee to the Company or any Affiliate of the Company. 
 (iv) If the Board determines that it
would not be in the best interests of the Company to exercise its repurchase right, such right may be assigned pro rata to the parties to the Shareholders Agreement, unless the parties to the Shareholders Agreement otherwise unanimously agree to a
different apportionment of the assigned repurchase right. 
 (d) Drag-Along Right. If the Majority Common Shareholders notify a
holder of Shares issued under the Plan that the Majority Common Shareholders desire to effect a Sale of the Company and specify the terms and conditions of such proposed sale then, such holder shall take all necessary and desirable actions
reasonably requested by such Majority Common Shareholders in connection with the consummation of such Sale of the Company, including, without limitation, if applicable, (i) within ten (10) business days of the receipt of such notice (or
such longer period of time as such Majority Common Shareholders shall designate in such notice) such holder shall cause a pro rata number of his Shares (for the avoidance of doubt, based on the percentage of Shares, on a diluted basis, owned by the
Majority Common Shareholders that is being sold) to be sold to the designated purchaser on the same terms and conditions, for the same per share consideration and at the same time as the Shares being sold by such Majority Common Shareholders or
(ii) otherwise participating in such Sale of the Company on the same terms and conditions and for the same consideration and at the same time as such Majority Common Shareholders. In furtherance, and not in limitation, of the foregoing, in
connection with a Sale of the Company, such holder will, (a) consent to and raise no objections against the Sale of the Company or the process pursuant to which it was arranged, (b) waive any dissenter’s rights and other similar
rights and (c) execute all documents containing such terms and 

  
 8 

 
conditions as those executed by such Majority Common Shareholders as directed by such Majority Common Shareholders. 
 (e) Voting. As to the election of members of the Board, each holder of Shares issued under the Plan shall vote, consent or take other action as directed by the Board which shall be consistent with the
provisions of the Shareholders Agreement, whether or not such holder is a party thereto. 
 (f) Transfer of ISO Shares. The
Grantee shall notify the Company of any transfer of Shares that were acquired upon exercise of an ISO that occurs within one year of such exercise or two years of the date the ISO was granted. 

(g) Qualifying Offering. The restrictions contained in subsections (b), (c), (d) and (e) above shall lapse upon a Qualifying
Offering; provided, however, that (i) the repurchase rights set forth in Section 8(c) in respect of any termination of employment occurring prior to the Qualifying Offering may continue to be exercised, and the repurchase right arising
under the circumstances described in clause (x) or (y) of Section 8(c)(ii) may continue to be exercised, regardless of when termination of employment occurs, and (ii) unless otherwise determined by the Committee, no Shares shall
be sold or distributed during the 180-day period beginning on the effective date of the Qualifying Offering (except as part of such underwritten registration) and each Grantee shall enter into such standstill agreements and related agreements as the
managing underwriters of such Qualifying Offering may request. 
 (h) Certificates for Shares. Shares issued under the Plan may
be evidenced in such manner as the Committee shall determine. If certificates representing Shares are registered in the name of a Grantee, such certificates may bear an appropriate legend referring to the terms, conditions, and restrictions
applicable to such Shares, and the Company may retain physical possession of the certificates, in which case the Grantee shall be required to have delivered a power of transfer to the Company, endorsed in blank, relating to the Shares. 

 

	Section 9.	Acceleration of Vesting. 

 Unless
otherwise determined by the Committee, all Options and Unvested Shares held by a Grantee shall become fully vested immediately prior to a Sale of the Company. 
  

	Section 10.	General Provisions 

 (a) Each
Option and Share grant shall be evidenced by a Grant Certificate. The terms and provisions of such certificates may vary among Grantees and among different Options and Shares granted to the same Grantee. 

(b) The grant of an Option or Shares in any year shall not give the Grantee any right to similar grants in future years, any right to
continue such Grantee’s employment relationship with the Company or its subsidiaries (for the applicable vesting period or otherwise), or, until Shares are issued pursuant to the exercise of an Option, any rights as a shareholder of the
Company. All Grantees shall remain subject to discharge to the same extent as if the Plan 

  
 9 

 
were not in effect. For purposes of the Plan, a sale of any subsidiary of the Company that employs a Grantee shall be treated as the termination of such Grantee’s employment unless such
Grantee remains employed by the Company or another subsidiary of the Company. 
 (c) No Grantee, and no beneficiary or other
persons claiming under or through the Grantee, shall have any right, title or interest by reason of any award under the Plan to any particular assets of the Company or subsidiaries of the Company, or any Shares allocated or reserved for the purposes
of the Plan or subject to any award except as set forth herein. The Company shall not be required to establish any fund or make any other segregation of assets to assure satisfaction of the Company’s obligations under the Plan. 

(d) The Plan shall be governed by and construed in accordance with the laws of the State of North Carolina, without giving effect to any
choice of law or conflict of law provision or rule (whether of the State of North Carolina or any other jurisdiction) that would cause the application of the laws of any jurisdiction other than the State of North Carolina. Each Grantee, and each
beneficiary or other person claiming under or through the Grantee consents to the exclusive jurisdiction of any state or federal court located within the State of North Carolina and irrevocably agrees that all actions or proceedings relating to the
Plan shall be litigated in such courts. Each Grantee, and each beneficiary or other person claiming under or through the Grantee accepts generally and unconditionally, the exclusive jurisdiction of the aforesaid courts and waives any defense of
forum non conveniens, and irrevocably agrees to be bound by any final and nonappealable judgment rendered thereby in connection with the Plan. Each Grantee, and each beneficiary or other person claiming under or through the Grantee further
irrevocably consents to the service of process out of any of the aforementioned courts in any such action or proceeding by the mailing of copies thereof via overnight courier, such service to become effective fourteen calendar days after such
mailing. 
  

	Section 11.	Effective Date; Amendment or Termination 

 The Plan was initially effective as of April 10, 2003 (the “Effective Date”). The Committee may, at any time, alter, amend, suspend, discontinue or terminate the Plan; provided, however,
that no such action shall adversely affect the rights of Grantees with respect to Options or Shares previously granted hereunder. The Committee shall also have the authority to establish separate sub-plans under the Plan with respect to Grantees
resident in a particular jurisdiction (the terms of which shall not be inconsistent with those of the Plan) if necessary or desirable to comply with the applicable laws of such jurisdiction. Any sub-plans (and modifications to Plan terms and
procedures arising thereunder) established under this Section 11 by the Committee shall be attached to this Plan document as appendices. Effective immediately prior to the grant (or exercise) of an Option or Shares to a resident of the State of
California, Appendix A shall be deemed adopted and incorporated as a part of this Plan. 

  
 10 

 APPENDIX A 

QUINTILES TRANSNATIONAL HOLDINGS INC. 
 2003 STOCK INCENTIVE PLAN 
 Provisions Applicable to California
Residents 
 Notwithstanding anything to the contrary otherwise appearing in the Plan, to the extent applicable, the
following provisions promulgated under the California Code, together with any and all amendments, supplements or revisions thereto, shall apply to any stock option or other award granted under the Plan to a resident of the State of California and,
in the event of any conflict or inconsistency between the following provisions and the provisions otherwise appearing in the Plan, the following provisions shall control, solely with respect to options or other awards granted under the Plan to
residents of the State of California: 
 ¶11,892, California, Rule 260.140.41., Compensatory option plans 

Options granted to employees [including insurance agents who are employees for purposes of Rule 701(c) under the Securities Act of 1933,
as amended (17 C.F.R. 230.701(c)], officers, directors, general partners, trustees (where the issuer is a business trust) managers, advisors or consultants of the issuer, its parents, its majority-owned subsidiaries or majority-owned subsidiaries of
the issuer’s parents as part of a compensatory benefit plan shall be pursuant to a plan or agreement that provides for all of the following: 
 (a) The total number of securities (which may be expressed as a specific number of securities or as a percentage of the total number of securities outstanding from time to time) which may be issued and
the persons eligible to receive options to purchase these securities. 
 (b) An exercise period of not more than 120 months from
the date the option is granted. 
 (c) The non-transferability of the options, provided that the plan or agreement may permit
transfer by will, by the laws of descent and distribution, to a revocable trust, or as permitted by Rule 701 of the Securities Act of 1933, as amended (17 C.F.R. 230.701). 
 (d) The proportionate adjustment of the number of securities purchasable and the exercise price thereof under the option in the event of a stock split, reverse stock split, stock dividend,
recapitalization, combination, reclassification or other distribution of the issuer’s equity securities without the receipt of consideration by the issuer, of or on the issuer’s class or series of securities underlying the option.

 (e) Unless employment is terminated for cause as defined by applicable law, the terms of the plan or option grant or a
contract of employment, the right to exercise in the event of termination of employment, to the extent that the optionee is entitled to exercise on the date employment terminates, continues until the earlier of the option expiration date or:

 (1) At least 6 months from the date of termination if termination was caused by death or disability. 

(2) At least 30 days from the date of termination if termination was caused by other than death or disability. 

(f) Options must be granted within 10 years from the date the plan or agreement is adopted or the date the plan or agreement is approved
by the issuer’s security holders, whichever is earlier. 

 (g) The plan or agreement must be approved by a majority of the outstanding securities
entitled to vote by the later of (1) within 12 months before or after the date the plan is adopted or the date the agreement is entered into or (2) prior to or within 12 months of the granting of any option or issuance of any security
under the plan or agreement in this state. Any option granted to any person in this state that is exercised before security holder approval is obtained must be rescinded if security holder approval is not obtained in the manner described in the
preceding sentence. Such securities shall not be counted in determining whether such approval is obtained. A foreign private issuer, as defined by Rule 3b-4 of the Securities Exchange Act of 1934, as amended (17 C.F.R. 240.3b-4), shall not be
required to comply with this subsection provided that the aggregate number of persons in this state granted options under all option plans and agreements and issued securities under all purchase and bonus plans and agreements does not exceed 35.

 (h) Compliance with Section 260.140.46 of these rules regarding the information required to be received by security
holders. 
 ¶l1,893, Rule 260.140.42, Compensatory purchase or bonus plans excluding option plans 

Securities (other than options) distributed or sold to employees [including insurance agents who are employees for purposes of Rule 701(c)
under the Securities Act of 1933, as amended (17 C.F.R. 230.701], officers, directors, general partners, trustees (where the issuer is a business trust), managers, advisors or consultants of the issuer, its parents, its majority-owned subsidiaries
or majority owned subsidiaries of the issuer’s parents as part of a compensatory benefit plan shall be pursuant to a plan or agreement that provides for all of the following: 

(a) The total number of securities (which may be expressed as a specific number of securities or as a percentage of the total number of
securities outstanding from time to time) which may be issued and the persons eligible to purchase securities under the plan or agreement. 
 (b) The nontransferability of the rights of any eligible person to acquire securities under the plan or agreement, provided that the plan or agreement may permit transfer of the rights to purchase
securities by will, by the laws of descent and distribution, to a revocable trust, or as permitted by Rule 701 of the Securities Act of 1933, as amended (17 C.F.R. 230.701). 
 (c) The proportionate adjustment of the number of securities allocated to any eligible person under the plan or agreement in the event of a stock split, reverse stock split, stock dividend,
recapitalization, combination, reclassification or other distribution of the issuer’s equity securities without the receipt of consideration by the issuer, of or on the issuer’s class of securities subject to the purchase right.

 (d) Securities must be issued within 10 years from the date the plan or agreement is adopted or the plan or agreement is
approved by the issuer’s security holders, whichever is earlier. 
 (e) The plan or agreement must be approved by a majority
of the outstanding securities entitled to vote by the later of (1) within 12 months before or after the plan is adopted or the date the agreement is entered into or (2) prior to or within 12 months of the issuance of any security
under the plan or agreement in this state. Any issuance of securities purchased before security holder approval is obtained must be rescinded if security holder approval is not obtained in the manner described in the preceding sentence. Such
securities shall not be counted in determining whether such approval is obtained. A foreign private issuer, as defined by Rule 3b-4 of the Securities Exchange Act of 1934, as amended (17 C.F.R. 240.3b-4), shall not be required to comply with this
subsection provided that the aggregate number of persons in this state granted options under all option plans and agreements and issued securities under all purchase and bonus plans and agreements does not exceed 35. 

(f) Compliance with Section 260.140.46 of these rules regarding the information required to be received by security holders.

 ¶11,896, Rule 260.140.45, Limitation on number of securities 

 (a) The total number of securities issuable upon exercise of all outstanding options
[exclusive of rights described in Section 260.140.40 and warrants described in Sections 260.140.43 and 260.140.44 of these rules, and any purchase plan or agreement as described in Section 260.140.42 of these rules (provided that the
purchase plan or agreement provides that all securities will have a purchase price of 100% of the fair value (Section 260.140.50) of the security either at the time the person is granted the right to purchase securities under the plan or agreement
or at the time the purchase is consummated)], and the total number of securities called for under any bonus or similar plan or agreement shall not exceed a number of securities which is equal to 30% of the then outstanding securities of the issuer
(convertible preferred or convertible senior common shares of stock will be counted on an as if converted basis), exclusive of securities subject to promotional waivers under Section 260.141, unless a percentage higher than 30% is approved by
at least two-thirds of the outstanding securities entitled to vote. 
 (b) The 30% limitation set forth in this Rule, or such
other percentage limitation as may be approved pursuant to this Rule, shall be deemed satisfied if the plan or agreement provides that at no time shall the total number of securities issuable upon exercise of all outstanding options and the total
number of securities provided for under any bonus or similar plan or agreement of the issuer exceed the applicable percentage as calculated in accordance with the conditions and the exclusions of this Rule, based on the securities of the issuer
which are outstanding at the time the calculation is made. 
 (c) This section shall not apply to any plan or agreement that
complies with all conditions of Rule 701 of the Securities Act of 1933, as amended (17 C.F.R. 230.701); provided that for purposes of determining such compliance, any registered domestic partner shall be considered a “family member” as
that term is defined in Rule 701. 
 ¶11,897, Rule 260.140.46, Information to security holders 

Plans or agreements pursuant to which securities are to be issued to employees, officers, directors, managers, advisors or consultants
(including option, purchase and bonus plans) shall provide that the security holder(s) will receive financial statements at least annually. This section does not require the use of financial statements in accordance with Section 260.613 of
these rules. This section shall not apply when issuance is limited to key persons whose duties in connection with the issuer assure them access to equivalent information. This section shall not apply to any plan or agreement that complies with all
conditions of Rule 701 of the Securities Act of 1933, as amended (17 C.F.R. 230.701); provided that for purposes of determining such compliance, any registered domestic partner shall be considered a “family member” as that term is defined
in Rule 701.

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