Document:

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                                                                   EXHIBIT 10.38

                                AMENDMENT TO THE
                               DOR BIOPHARMA, INC.
                AMENDED AND RESTATED 1995 OMNIBUS INCENTIVE PLAN

The Amended and Restated 1995 Omnibus Incentive Plan of DOR BioPharma, Inc. (the
"Company"), as initially adopted by the Company's Board of Directors on April
24, 1995, amended on July 15, 1996, amended and restated on October 21, 1997,
and amended on February 11, 1998, February 21, 2001, May 16, 2001 and September
26, 2001 (as so amended, the "Plan") is hereby amended, subject to approval at a
meeting of stockholders by the vote of a majority in voting interest of the
stockholders of the Company, present in person or by proxy and entitled to vote
thereat and thereon, as follows:

1. To increase the number of shares of Common Stock issuable under the Plan to
11,000,000 shares, Section V.A. of Article One of the Plan is hereby amended by
deleting the number "4,500,000" and substituting therefore the number
"11,000,000."

2. To increase the maximum number of shares of Common Stock underlying options
and separately exercisable stock appreciation rights that any person
participating in the Plan may receive in any year to 2,500,000 shares, Section
V.C. of Article One of the Plan is hereby amended by deleting the number
"750,000" and substituting therefore the number "2,500,000."

3. As modified herein, the Plan shall remain in full force and effect.

IN WITNESS WHEREOF, the Company has caused this amendment to be executed by its
duly authorized officer this 23rd day of December, 2002.

                                             DOR BIOPHARMA, INC.

                                             By: /s/ William D. Milling
                                                --------------------------------
                                                 William D. Milling
                                                 Controller/Treasurer/Secretary<PAGE>
                                                                   EXHIBIT 10.39

December 20, 2002

General Alexander M. Haig, Jr.
Chairman
Worldwide Associates, Inc.
1155 15th Street N.W.
Suite 800
Washington DC  20005

         Re:   DOR BioPharma Board Membership Letter Agreement

Dear General:

It was a pleasure speaking with you again. It gives me great pleasure to offer
you to become a member of the board of directors of DOR BioPharma, Inc. ("DOR")
and as a non-executive Chairman of the Board.

In your capacity as a non-executive Chairman of the Board, you will not be
considered an executive, officer or employee of DOR and as such will have no
responsibilities attendant therewith. Your only responsibilities will be to
attend board meetings of DOR on a best efforts basis, comparable to the
responsibilities of the other non-executive members of the board. You will not
have any duties outside of your attendance of meetings of the board not
otherwise applicable to other board members. Specifically, for clarification,
you will not be required to participate or assist management in the preparation
of board meetings in advance of such meetings, for example. All such
responsibilities shall remain the exclusive responsibility of the executive
officers and management of DOR. It is anticipated that a new executive position
of Vice Chairman may be created to handle any and all executive responsibilities
of coordinating the board of directors in advance of board meetings and to
assist the President and Chief Executive Officer with matters to be presented to
the board. You shall also not be required to participate in any committee of the
board that may be established. The company intends to establish executive
offices in the area surrounding Washington, DC so as to be in close working
proximity in the FDA, DoD and NIH and it is anticipated that future in person
board meetings will be held in the Washington, DC area to the extent possible.

As part of the position of non-executive Chairman, DOR shall also immediately
issue to you fully-vested options to acquire two million (2,000,000) shares of
DOR common stock for (10) years at an exercise price of thirty-five cents
($0.35) per share of which 900,000 options shall be subject to stockholder
certification, which the Company shall seek to obtain as soon as possible.

DOR shall pay you a fee of fifty thousand dollars ($50,000) per annum, payable
quarterly in advance, plus board fees for attendance of meetings consistent with
the policy regarding other non-executive members of the board, which is
currently two thousand dollars ($2,000) per in-

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General Alexander M. Haig, Jr.
December 20, 2002
Page 2

person meeting and one thousand dollars ($1,000) per telephonic meeting, plus
reimbursement of all expenses.

DOR shall fully indemnify you for any acts and omissions to the fullest extent
permitted under Delaware Law include you as a covered person pursuant to DOR's
D&O policy, currently five million dollars ($5,000,000).

You shall be required to acknowledge DOR's insider trading policies and policies
protecting proprietary information of DOR, consistent with that of other members
of the board of directors. Such policies will be forwarded to you under separate
letter.

On behalf of the other members of the board and myself, we welcome you to the
board and look forward to working with you.

If the foregoing accurately sets forth your understanding of our present intent,
kindly so indicate by executing the counterpart in the space provided and
returning to me via fax at 305-789-6664.

                                    Sincerely,

                                    Steve H. Kanzer, CPA, Esq.
                                    President

Agreed to and Accepted:

-----------------------------------
General Alexander M. Haig, Jr.<PAGE>
                                                                   EXHIBIT 10.40

                              EMPLOYMENT AGREEMENT

         This Agreement (the "Agreement"), dated as of March 4, 2003 (the
"Effective Date") by and between DOR BioPharma, Inc., a Delaware corporation
having a place of business at 28101 Ballard Drive, Lake Forest, IL 60045 (the
"Corporation"), and Ralph Ellison, M.D. an individual (the "Employee").

                              W I T N E S S E T H:

         WHEREAS, the Corporation desires to employ Employee as Chief Executive
Officer and President and the Employee desires to be employed by the Corporation
as Chief Executive Officer and President all pursuant to the terms and
conditions hereinafter set forth;

         NOW, THEREFORE, in consideration of the foregoing and the mutual
promises and covenants herein contained, it is agreed as follows:

1.       EMPLOYMENT; DUTIES

         (a) The Corporation engages and employs Employee, and Employee hereby
accepts engagement and employment, as President and Chief Executive Officer, and
shall perform high quality, full-time service to the Corporation to direct,
supervise and have responsibility for the operations of the Corporation,
including, but not limited to: (i) directing and supervising the business and
clinical and research and development efforts of the Corporation; (ii) managing
the other executives and personnel of the Corporation and (iii) evaluating,
negotiating, structuring and implementing business transactions with the
Corporation's customers and suppliers and such other activities as may be
reasonably requested by the Vice Chairman and Board of Directors of the
Corporation. While the Employee remains employed by the Corporation, the
Corporation shall use its best efforts to appoint the Employee to the Board of
Directors of the Corporation. Employee agrees to submit his written resignation
from the Board of Directors immediately if Employee ceases to be President and
Chief Executive Officer. Employee acknowledges and understands that his
employment may entail significant travel on behalf of the Corporation.

         (b) The Corporation and the Employee acknowledge that the Employee is a
consultant to Cell Therapeutics, Inc. and it's subsidiary PolaRx
BioPharmaceuticals, Inc. ("CTI") in the area of Arensic compounds for the
treatment of cancers. Employee shall seek to substantially reduce his
obligations to CTI within three (3) months of joining the Corporation and he
will spend a majority of his time on the Corporation's business. With regard to
any further work conducted for CTI, the Employee warrants that such work, if
any, shall not interfere with the duties and obligations that the Employee owes
the Corporation..

2.       EMPLOYMENT TERM

         Employee's employment hereunder shall be for a period of three (3)
years.

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3.       COMPENSATION

     A.  As compensation for the performance of employee's duties on behalf of
         the Corporation, Employee shall be compensated as follows:

              (a)          (i) The Corporation shall pay Employee an annual base
                  salary ("Base Salary") of two hundred thousand dollars
                  ($200,000) per annum, payable in accordance with the usual
                  payroll period of the Corporation.

                           (ii) Upon the successful completion of an equity
                  financing by the Corporation of at least one million dollars
                  ($1,000,000), the Corporation shall pay Employee a Base Salary
                  of three hundred thousand dollars ($300,000) per annum,
                  payable in accordance with the usual payroll period of the
                  Corporation;

              (b)          (i) On the day immediately preceding the first
                  anniversary of the Employee's employment hereunder and upon
                  each subsequent anniversary of the Employee's employment, the
                  Employee will receive a cash bonus ("Bonus") of 30% of the
                  Employee's average base salary earned in the preceding year.
                  Such bonus will accrue evenly throughout the year and will be
                  paid in a lump sum on the days set forth in this paragraph
                  3A(b)(i). In the event that prior to such date, this Agreement
                  has been terminated by either the Corporation or Employee,
                  then within ten (10) business days following the date of such
                  termination, the Corporation shall pay in a lump sum to the
                  Employee the pro rata portion of the Bonus accrued through the
                  date of such termination.

     B. Contingent upon your acceptance of this Agreement, the Compensation
     Committee of the Board of Directors will grant to you Options ("Options")
     to purchase two million (2,000,000) shares of DOR Common Stock, vesting
     over three years priced as of the Effective Date of this Agreement. One
     third (1/3 or 667,000) of the Options shall vest immediately, one third
     (1/3 or 667,000) shall vest on the first anniversary of employment and one
     third (1/3 or 666,000) shall vest on the second anniversary of employment.
     In the event of a Change in Control of the Company (as defined in the
     Corporation's Amended and Restated 1995 Omnibus Incentive Plan (the
     "Plan"), any unvested Options shall immediately be fully vested. The
     Employee acknowledges that the Corporation is required to increase the
     number of shares reserved under the Plan and to amend the Plan to permit
     larger option grants, and the Options granted to the Employee are subject
     to the approval by the stockholders of the Corporation to amend the Plan in
     such regard. The Options will be granted pursuant to the Plan and the
     Corporation's standard Notice of Grant of Stock Option. .

         (c) The Corporation shall withhold all applicable federal, state and
local taxes, social security and workers' compensation contributions and such
other amounts as may be required by law or agreed upon by the parties with
respect to the compensation payable to the Employee pursuant to section 3(A)
hereof.

         (d) The Corporation shall reimburse Employee for all normal, usual and
necessary expenses incurred by Employee in furtherance of the business and
affairs of the Corporation,

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including reasonable travel and entertainment, against receipt by the
Corporation of appropriate vouchers or other proof of Employee's expenditures
and otherwise in accordance with the policy of the Corporation.

         (e) Employee shall be, during the term of this Agreement, entitled to a
minimum of three (3) weeks paid vacation per annum. Unused vacation may be
carried over to successive years.

         (f) The Corporation shall make available to Employee and his
dependents, such medical, disability, life insurance and such other benefits, as
the Corporation makes available to its other senior officers and directors.

4.       REPRESENTATIONS AND WARRANTIES BY
         EMPLOYEE AND CORPORATION

         (a) Employee hereby represents and warrants to the Corporation as
follows:

                  (i) Neither the execution and delivery of this Agreement nor
the performance by Employee of his duties and other obligations hereunder
violate or will violate any statute, law, determination or award, or conflict
with or constitute a default under (whether immediately, upon the giving of
notice or lapse of time or both) any prior employment agreement, contract, or
other instrument to which Employee is a party or by which he is bound.

                  (ii) Employee has the full right, power and legal capacity to
enter and deliver this Agreement and to perform his duties and other obligations
hereunder. This Agreement constitutes the legal, valid and binding obligation of
Employee enforceable against him in accordance with its terms. No approvals or
consents of any persons or entities are required for Employee to execute and
deliver this Agreement or perform his duties and other obligations hereunder.

         (b) The Corporation hereby represents and warrants to Employee as
follows:

                  (i) The Corporation is duly organized, validly existing and in
good standing under the laws of the State of Delaware, with all requisite
corporate power and authority to own its properties and conduct its business in
the manner presently contemplated.

                  (ii) The Corporation has full power and authority to enter
into this Agreement and to incur and perform its obligations hereunder. This
Agreement constitutes the legal, valid and binding obligation of the Corporation
enforceable against it in accordance with its terms. Except as expressly set
forth herein, no approvals or consents of any persons or entities are required
for Corporation to execute and deliver this Agreement or perform its duties and
other obligations hereunder.

                  (iii) The execution, delivery and performance by the
Corporation of this Agreement does not conflict with or result in a breach or
violation of or constitute a default under

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(whether immediately, upon the giving of notice or lapse of time or both) the
certificate of incorporation or by-laws of the Corporation, or any agreement or
instrument to which the Corporation is a party or by which the Corporation of
any of its properties may be bound or affected.

5.       NON-COMPETITION

         (a)      Employee understands and recognizes that his services to the
                  Corporation are special and unique and agrees that, during the
                  term of this Agreement and for a period of two (2) years from
                  the date of termination of his employment hereunder, he shall
                  not in any manner, directly or indirectly, on behalf of
                  himself or any person, firm, partnership, joint venture,
                  corporation or other business entity ("Person"), enter into or
                  engage in any business competitive with the Corporation's
                  business, or research activities, either as an individual for
                  his own account, or as a partner, joint venturer, executive,
                  agent, consultant, salesperson, officer, director of a Person
                  operating or intending to operate in the area of the use of
                  any of the compounds owned or licensed by the Corporation
                  during the time of his employ.

         (b)      During the term of this Agreement and for two (2) years
                  thereafter, Employee shall not, directly or indirectly,
                  without the prior written consent of the Corporation:

                     (i) interfere with, disrupt or attempt to disrupt any past,
                  present or prospective relationship, contractual or otherwise
                  between the Corporation and any of its licensors, licensees,
                  clients, customers, suppliers, employees, consultants or other
                  related parties, or solicit or induce for hire any of the
                  employees, or agents, of the Corporation or any such
                  individual who in the past was employed or retained by the
                  Corporation within six (6) months of the termination of said
                  individual's employment or retention by the Corporation; or

                     (ii) solicit or accept employment or be retained by any
                  party who, at any time during the term of this Agreement, was
                  a customer or supplier of the Corporation or any of its
                  affiliates or any licensor or licensee thereof where his
                  position will be related to the business of the Corporation;
                  or

                      (c) In the event that Employee breaches any provisions of
                  this Section 5 or there is a threatened breach, then, in
                  addition to any other rights which the Corporation may have,
                  the Corporation shall be entitled, without the posting of a
                  bond or other security, to injunctive relief to enforce the
                  restrictions contained herein. In the event that an actual
                  proceeding is brought in equity to enforce the provisions of
                  this Section 5, Employee shall not urge as a defense that
                  there is an adequate remedy at law nor shall the Corporation
                  be prevented from seeking any other remedies which may be
                  available.

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6.       CONFIDENTIAL INFORMATION

         (a) Employee agrees that during the course of his employment or at any
time after termination, he will not disclose or make accessible to any other
person, the Corporation's or any of its subsidiaries or affiliates,
(collectively the "Affiliates") products, services and technology, both current
and under development, promotion and marketing programs, business plans, lists,
customer lists, product or licensing opportunities, investor lists, trade
secrets and other confidential and proprietary business information of the
Corporation or the Affiliates. Employee agrees: (i) not to use any such
information for himself or others; and (ii) not to take any such material or
reproductions thereof in any form or media from the Corporation's facilities at
any time during his employment by the Corporation, except as required in
Employee's duties to the Corporation. Employee agrees immediately to return all
such material and reproductions thereof in his possession to the Corporation
upon request and in any event upon termination of employment.

         (b) Except with prior written authorization by the Corporation,
Employee agrees not to disclose or publish any of the confidential, technical or
business information or material of the Corporation, to any suppliers,
licensors, licensees, customers, partners or other third parties to whom the
Corporation owes an obligation of confidence, at any time during or after his
employment with the Corporation.

         (c) Employee hereby assigns to the Corporation all right, title and
interest he may have or acquire in all inventions (including patent rights)
developed by Employee during the term of this Agreement ("Inventions") and
agrees that all Inventions shall be the sole property of the Corporation and its
assigns, and the Corporation and its assigns shall be the sole owner of all
patents, copyrights and other rights in connection therewith. Employee further
agrees to assist the Corporation in every proper way (but at the Corporation's
expense) to obtain and from time to time enforce patents, copyrights or other
rights on said Inventions in any and all countries. Employee hereby irrevocably
designates counsel to the Corporation as Employee's agent and attorney-in-fact
to do all lawful acts necessary to apply for and obtain patents and copyrights
and to enforce the Corporation's rights under this Section. This Section shall
survive the termination of this Agreement for any reason.

         (d) The Employee recognizes that in the course of his duties hereunder,
he may receive from Affiliates or others information which may be considered
"material, nonpublic information" concerning a public company that is subject to
the reporting requirements of the Securities and Exchange Act of 1934, as
amended. The Employee agrees not to:

                           (i) Buy or sell any security, option, bond or warrant
while in possession of relevant material, nonpublic information received from
Affiliates or others in connection herewith;

                           (ii) Provide Affiliates with information with respect
to any public company that may be considered material, nonpublic information,
unless first specifically agreed to in writing by Paramount; or

<PAGE>
                           (iii) Provide any person with material, nonpublic
information, received from Affiliates including any relative, associate, or
other individual who intends to, or may, (a) trade securities with respect to
Paramount which is the subject of such information, or (b) otherwise directly or
indirectly benefit from such information.

7. TERMINATION

         (a) The Employee's employment hereunder shall begin on the Effective
Date and shall continue for the period set forth in Section 2 hereof unless
renewed by mutual agreement or sooner terminated upon the first to occur of the
following events:

                  (i)      The death of the Employee;

                  (ii) Merger or consolidation in which either more than fifty
percent of the voting power of the Corporation is transferred or the Corporation
is not the surviving entity, or sale or other disposition of all or
substantially all the assets of the Corporation;

                  (iii) Termination by the Board of Directors of the Corporation
for Just Cause. Any of the following actions by the Employee shall constitute
"Just Cause":

                           (A) Material breach by the Employee of Section 1,
                  Section 5 or Section 6 of this Agreement;

                           (B) Material breach by the Employee of any provision
                  of this Agreement other than Section 5 or Section 6 which is
                  not cured by the Employee within thirty (30) days of notice
                  thereof from the Corporation;

                           (C) Any action by the Employee to intentionally harm
                  the Corporation; or any action of gross negligence by the
                  Employee;

                           (D) The conviction of the Employee of a felony;

                      (iv) Termination by the Employee for Just Cause. Any of
         the following actions or omissions by the Corporation shall constitute
         just cause:

                           (A) Material breach by the Corporation of any
                  provision of this Agreement which is not cured by the
                  Corporation within thirty (30) days of notice thereof from the
                  Employee; or

                           (B) Any action by the Corporation to intentionally
                  harm the Employee.

         (b) Upon termination by Employer pursuant to either subparagraph (i) or
(iii) of paragraph (a) above or by Employee other than pursuant to subparagraph
(iv) of paragraph (a) above, the Employee (or his estate in the event of
termination pursuant to subparagraph (i), shall

<PAGE>

be entitled to receive the Base Salary plus Bonus accrued but unpaid as of the
date of termination including any vacation time accrued but not taken.
(c) Upon termination by the Corporation without Just Cause or pursuant to
subparagraphs (ii) or (iv) of paragraph (a) above, then the term of the
Agreement as set forth in Section 2 hereof shall be deemed to have been
terminated as of such date and (i) the Corporation shall pay to the Employee,
six (6) months salary and any unpaid Bonuses payable upon the normal payroll
periods of the Corporation including any vacation accrued but not taken, and
(ii) all unvested Options granted under Paragraph 3B of the Agreement shall vest
immediately.

         (d) Not withstanding any of the foregoing, sections 3 and 7 shall
survive the termination or expiration of this Agreement.

8.       NOTICES

         Any notice or other communication under this Agreement shall be in
writing and shall be deemed to have been given: when delivered personally
against receipt therefor; one (1) day after being sent by Federal Express or
similar overnight delivery; or three (3) days after being mailed registered or
certified mail, postage prepaid, return receipt requested, to either party at
the address set forth above, or to such other address as such party shall give
by notice hereunder to the other party.

9.       SEVERABILITY OF PROVISIONS

         If any provision of this Agreement shall be declared by a court of
competent jurisdiction to be invalid, illegal or incapable of being enforced in
whole or in part, such provision shall be interpreted so as to remain
enforceable to the maximum extent permissible consistent with applicable law and
the remaining conditions and provisions or portions thereof shall nevertheless
remain in full force and effect and enforceable to the extent they are valid,
legal and enforceable, and no provision shall be deemed dependent upon any other
covenant or provision unless so expressed herein.

10.      ENTIRE AGREEMENT MODIFICATION

         This Agreement contains the entire agreement of the parties relating to
the subject matter hereof, and the parties hereto have made no agreements,
representations or warranties relating to the subject matter of this Agreement
which are not set forth herein. No modification of this Agreement shall be valid
unless made in writing and signed by the parties hereto.

11.      BINDING EFFECT

         The rights, benefits, duties and obligations under this Agreement shall
inure to, and be binding upon, the Corporation, its successors and assigns, and
upon Employee and his legal representatives. This Agreement constitutes a
personal service agreement, and the performance of Employee's obligations
hereunder may not be transferred or assigned by Employee.

<PAGE>

12.      NON-WAIVER

         The failure of either party to insist upon the strict performance of
any of the terms, conditions and provisions of this Agreement shall not be
construed as a waiver or relinquishment of future compliance therewith, and said
terms, conditions and provisions shall remain in full force and effect. No
waiver of any term or condition of this Agreement on the part of either party
shall be effective for any purpose whatsoever unless such waiver is in writing
and signed by such party.

13.      GOVERNING LAW

         This Agreement shall be governed by, and construed and interpreted in
accordance with, the laws of the State of Florida without regard to principles
of conflict of laws.

14.      HEADINGS

         The headings of paragraphs are inserted for convenience and shall not
affect any interpretation of this Agreement.

         IN WITNESS WHEREOF, the parties hereto have executed this Agreement as
of the day and year first above written.

                                                     DOR BIOPHARMA, INC.

                                                     By:   _____________________
                                                     Steve H. Kanzer
                                                     Vice Chairman

                                                     EMPLOYEE:

                                                     RALPH ELLISON, M.D.

                                                     By:  ______________________

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