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    EXHIBIT
      4.1 

     

     

    
 

    SUPPLEMENTAL
      INDENTURE NUMBER TWO

    to
      the

    INDENTURE

    Dated
      as
      of December 14, 2006

    among

    

    AMERICAN
      HOME MORTGAGE INVESTMENT TRUST 2006-2,
      as
      Issuing Entity,

    

    WELLS
      FARGO BANK, N.A., as Securities Administrator

    

    and

    

    DEUTSCHE
      BANK TRUST COMPANY AMERICAS, as Indenture Trustee

    

    

    SUPPLEMENTAL
      INDENTURE NUMBER TWO, dated December 14, 2006, between AMERICAN
      HOME MORTGAGE INVESTMENT TRUST 2006-2
      as the
      issuing entity (the “Issuing Entity”), WELLS FARGO BANK, N.A., as securities
      administrator (“Securities Administrator”) and DEUTSCHE BANK NATIONAL TRUST
      COMPANY as the indenture trustee (the “Indenture Trustee”) in connection with
      the Indenture dated as of June
      30,
      2006 between the above mentioned parties (the “Indenture”) and the issuance of
      Mortgage-Backed Notes, Series 2006-2. This amendment is made pursuant to Section
      9.01(b) of the Indenture.

    

    1. Capitalized
      terms not defined herein have the meanings assigned to them in the
      Indenture.

    

    2. The
      definition for “Determination Date” in the Appendix A to the Indenture is hereby
      deleted in its entirety as of the date hereof and replaced with the
      following:

    

    Determination
      Date:
      With
      respect to any Payment Date, the 15th of the related month, or if the 15th
      day
      of such month is not a Business Day, the immediately preceding Business
      Day.

    

    3. Notice
      of
      this Supplemental Indenture has been given to each of Standard & Poor’s, a
      division of The McGraw-Hill Companies, Inc., Fitch Ratings and Moody’s Investors
      Service, Inc. pursuant to 9.01(b) of the Indenture.

    

    4. Except
      as
      amended above, the Indenture shall continue to be in full force and effect
      in
      accordance with its terms.

    

    

    [Signature
      Page Follows]

    

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

     

     

    IN
      WITNESS WHEREOF, the Issuing Entity, the Securities Administrator and the
      Indenture Trustee have caused their duly authorized representatives to execute
      and deliver this instrument as of the date first above written.

    

     

    
      	 	 	 	 	 	 	 	
              AMERICAN
                HOME MORTGAGE INVESTMENT TRUST 2006-2,

              as
                Issuing Entity

            
	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	
              By:

            	
              WILMINGTON
                TRUST COMPANY,

              not
                in its individual capacity but solely as Owner Trustee

            
	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	
              By:

            	 
	 	 	 	 	 	 	 	
              Name:

            	 
	 	 	 	 	 	 	 	
              Title:

            	 

    

    

     

    

     

    
      	 	 	 	 	 	 	 	
              WELLS
                FARGO BANK, N.A., as Securities Administrator

            
	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	
              By:

            	 
	 	 	 	 	 	 	 	
              Name:

            	 
	 	 	 	 	 	 	 	
              Title:

            	 

    

    

     

    

     

    
      	 	 	 	 	 	 	 	
              DEUTSCHE
                BANK TRUST COMPANY AMERICAS,

              not
                in its individual capacity but solely as Indenture
                Trustee

            
	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	
              By:

            	 
	 	 	 	 	 	 	 	
              Name:

            	 
	 	 	 	 	 	 	 	
              Title:

            	 
	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	
              By:

            	 
	 	 	 	 	 	 	 	
              Name:

            	 
	 	 	 	 	 	 	 	
              Title:

            	 

    

    

    

    
      	
              Acknowledged
                and Agreed:

            	 
	 	 
	 	 
	
              CIFG
                ASSURANCE NORTH AMERICA, INC.,

              as
                Credit Enhancer

            	 
	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	
              By:

            	 	 	 
	
              Name:

            	 	 	 
	
              Title:<PAGE>

                                                                   EXHIBIT 10.28

                      FIRST AMENDMENT TO SUBLEASE AGREEMENT

     This First Amendment ("Amendment") is dated for reference purposes April
13, 2001, and amends that certain Sublease Agreement dated March 30,2001 (the
"Sublease") made by and between F5 Networks, Inc., a Washington corporation, as
Sublandlord, and Cell Therapeutics, Inc., a Washington corporation, as
Subtenant. The capitalized terms in this Amendment shall have the meaning given
to those same terms in the Sublease, unless a different meaning has been
provided herein.

     NOW, THEREFORE, the parties hereby amend the Sublease as follows:

1. Security Deposit. The Sublease is hereby amended by deleting the second to
the last sentence of Section 7. Sublandlord will apply the balance of the
Subtenant's cash security deposit in the amount of sixty-five thousand eight
hundred sixty-four dollars and seventy-nine cents ($65,864.79) deposited under
the Prior Sublease (as defined in Section 2 of the Sublease) against the Base
Rent due for the first month of the Term.

2. Letter of Credit. The amount of the letter of credit to be posted by
Subtenant pursuant to Section 7 of the Sublease is hereby amended to be six
hundred seventy thousand dollars ($670,000).

3. Use of Subleased Premises. Section 8 of the Sublease is deleted in its
entirety and replaced with the following:

     Subtenant may use the Sublease Premises for laboratory uses of the types
     generally permitted by institutional landlords of similar buildings of
     multi-tenant developments in the Seattle area, provided that Subtenant
     shall comply with any special restrictions or precautions imposed by Master
     Landlord.

4. Alterations. Section 10 of the Sublease is amended by adding the following
new paragraph at the end of that Section:

     Master Landlord may (and is expected to) require Sublandlord to post or
     arrange for the posting of a Letter of Credit securing restoration
     obligations under the Master Lease if the Subleased Premises are materially
     altered from their current improved state and Master Landlord requires that
     Sublandlord remove any proposed alterations to be installed by Subtenant
     pursuant to the terms of the Master Lease and the Master Landlord's Consent
     referenced in Section 14 below (the "Restoration Deposit"). Subtenant shall
     post the Restoration Deposit directly with Master Landlord. Sublandlord
     shall have no obligation to post the Restoration Deposit.

<PAGE>

5. Conditions Precedent. Section 14 of the Sublease is hereby deleted in its
entirety and replaced with the following:

     This Sublease is conditioned upon Master Landlord consenting to this
     Sublease pursuant to the Landlor's Constent to Subleasing attached to this
     Amendment as Exhibit A (the "Master Landlord Consent"). If Master Landlord
     has not so consented to this Sublease within thirty (30) days after this
     Sublease has been signed by Sublandlord and Subtenant, then either party
     may terminate this Sublease by delivering written notice of termination to
     the other party.

6. Miscellaneous. In the event of any conflict between the terms of this
Amendment and the Sublease, this Amendment shall control. The parties hereby
ratify and confirm their obligations under the Sublease as amended by this
Amendment. This Amendment, the Sublease, the exhibits attached to the Sublease
and this Amendment, and the Master Lease constitute the entire agreement between
Sublandlord and Subtenant with respect to the Subleased Premises, and may not be
amended or altered except by written agreement executed by both parties. This
Amendment may be executed in one or more counterparts; each signed counterpart
shall be deemed an original and all counterparts together shall constitute a
single, integrated agreement. Facsimile transmission of any signed original
document, and retransmission of any signed facsimile transmission, shall be the
same as delivery of an original. At the request of either party, the parties
will confirm facsimile transmitted signatures by signing an original document.

<PAGE>

IN WITNESS WHEREOF, the parties hereto hereby execute this Amendment as of day
and year first above written.

                                        SUBLANDLORD:

                                        F5 Networks, Inc., a Washington
                                        corporation

                                        By:
                                            ------------------------------------
                                        Name:
                                              ----------------------------------
                                        Title:
                                               ---------------------------------

                                        SUBTENANT:

                                        Cell Therapeutics, Inc., a Washington
                                        corporation

                                        By:
                                            ------------------------------------
                                        Name:
                                              ----------------------------------
                                        Title:
                                               ---------------------------------

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