Document:

Amendment Two to Software License Agreement

 EXHIBIT 10.7B 
  
 AMENDMENT TWO TO SOFTWARE 
 LICENSING AGREEMENT 
  
 This Amendment Two
to the Software Licensing Agreement (the “Amendment”) dated February 28, 2004 (the “Effective Date”) shall serve to amend the Software Licensing Agreement dated April 26, 2002, including any and all previous amendments thereto
(the “Agreement”) by and between Altiris, Inc., a Delaware corporation (“Licensor”) and Dell Products L.P (“Dell”). 
  
 Dell and Altiris seek to amend the Agreement as further set forth herein to adjust revenues paid and to include a new version of the Licensed Product. 
  
 Notwithstanding any provision to the contrary, the Agreement will be amended as of the
Effective Date hereof to affect the following: 
  

	 	1.	All capitalized terms which are not defined in this Amendment shall have the meaning as set forth in the Agreement. 

  

	 	2.	Section 3.2 (c) is deleted in its entirety and shall be replaced with the following [*] 

  

	 	3.	Section 3.2 (f) shall be deleted in its entirety and replaced with the following [*] 

  

	 	4.	The language in Section 6.3 shall be deleted in its entirety and replaced with the following [*] 

	 	[*]	This provision is the subject of a Confidential Treatment Request. 

  

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	5.	The Supplement to Software Licensing Agreement shall be deleted in its entirety and replaced with the language in Exhibit A attached hereto. 

  

	6.	All other terms and conditions not expressly amended herein shall remain in full force and effect as set forth in the Agreement. Should a conflict arise between this Amendment and
the Agreement, the provisions of this Amendment shall control. 

  

									
	DELL PRODUCTS L.P. (“Dell”)	 	 	 	ALTIRIS, INC. (“Licensor”)
					
	By:	 	/s/ David F. Brown	 	 	 	By:	 	/s/ Rob Wellman
	 	 	
	 	 	 	 	 	

					
	Printed Name:	 	David F. Brown	 	 	 	Printed Name:	 	Rob Wellman
	 	 	
	 	 	 	 	 	

					
	Title:	 	V.P.	 	 	 	Title:	 	VP Strategic Alliances
	 	 	
	 	 	 	 	 	

					
	Date:	 	3-22-04	 	 	 	Date:	 	3-24-04
	 	 	
	 	 	 	 	 	

			
	 	 	 	 	 Reviewed by Altiris Legal

					
	 	 	 	 	 	 	By:	 	/s/ EKG
	 	 	 	 	 	 	 	 	

	 	 	 	 	 	 	 Date:
	 	 3/24/04

  

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 EXHIBIT A 
  

SUPPLEMENT TO 
  
 SOFTWARE LICENSING AGREEMENT (AMENDED) 
  
 This Supplement provides additional terms and conditions to the Agreement. All terms and conditions of the Agreement apply to this Supplement and the terms and conditions
of this Supplement are hereby incorporated by reference into the Agreement. 
  

	1.0	DESCRIPTION OF LICENSED PRODUCT(S) 

  

						
			
	(A	) CODE	 	 	  	Dell OpenManage Client Administrator 2.0 consisting of Altiris Client Management Suite version 6.0.
			
	(B	) DOCUMENTATION	 	 	  	 

  
  

	
	 Documentation:

	 Product Requirements Document - Feature and Function Definitions

	 Description of each feature/function

	 What part of the product was changed to incorporate this feature/function

	 Release requirements/features

	 Functional Specs

	 Description for requirement implementation

	 Definition of how each feature/function is implemented

	 Interaction between this feature/function and the other features/functions

	 Test Plan

	 Test results for each requirement

	 Version descriptions of each test tool

	 Test tools (tools, cases and environment vendor uses to test the product)

	 Degree of automation defined

	 How each feature/function was tested

	 Technical Support Statistics (when available)

	 Call volume

	 Types of problems reported

	 Supporting statistical data

	 Resolution for high call drivers for this product

	 Portal into Customer Services Help Desk

	 Portal into Developer Help Desk

	 User Documentation

	 Installation Guide

	 User’s Guide

	 On-Line Help

	 Release Notes (the following may be consolidated within 1 document)

	 Change Notification Process

	 Known limitations for this release

	 What was fixed in this release

	 Any installation changes

	 List of new features added in this release

	 Technical Training Materials for Technical Support and Sales (in collaboration with Dell)

	 Resource Tool Kit

	 Portal to Licensor Demo Web Site

  

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	 Dell and Altiris Integration:

	 Any debugging utilities in the Resource Tool Kit

	 Developer’s documentation and Usage Models in the Resource Tool Kit

	 Engineering Troubleshooting Guide in the Resource Tool Kit, when available or provided in Engineering Training

	 Other docs/specs/API/utilities that will facilitate the integration, as available in the Resource Tool Kit

  

	3.0	DELIVERY SCHEDULE / TECHNICAL CONTACTS FOR LICENSED PRODUCTS 

  
 Technical contacts will be identified in Exhibit C. The delivery schedule for the Licensed Product(s) shall be as follows: 
  
 [*] 
  

	4.0	DESCRIPTION OF LICENSOR APPLICATION(S)  

  

						
			
	(A	) CODE	 	 	  	Licensor Applications are as listed in the Dell Price List attached hereto as Exhibit F.
			
	(B	) DOCUMENTATION	 	 	  	User documentation varies by product offering.

  

	5.0	COMPENSATION FOR LICENSED PRODUCT(S) AND LICENSOR APPLICATION(S) 

  
 The Dell Price List is attached hereto as Exhibit F. 
  

	6.0	DELIVERY SCHEDULE FOR LICENSOR APPLICATIONS / TECHNICAL CONTACTS 

  
 Technical contacts will be identified in Exhibit C. Licensor Application(s) shall be made available to Dell upon execution
of this Agreement. 
  

	7.0	ACCEPTANCE CRITERIA 

  
 Dell shall accept the Licensed Product(s) and Limited Product(s) when the following terms and conditions are fully satisfied and documented: 

 

	7.1	[*] 

  

	7.2	[*] 

  

	7.3	[*] 

  

	 	[*]	This provision is the subject of a Confidential Treatment Request. 

  
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	7.4	[*] 

  

	7.5	[*] 

  

	8.0	NEW PRODUCTS 

  
 During the term of the Agreement, the Parties agree to exercise reasonable efforts to meet no less than once per quarter to discuss their mutual business
objectives, which include, but are not limited to, product roadmaps and the possible evaluation of new Licensor products. Licensor shall make commercially reasonable efforts to provide Dell an evaluation copy of new Licensor products (subject to a
written evaluation agreement). If Dell wants to license such new product from Licensor, the new product will be added to this Agreement as mutually agreed upon in a written 

  

  

	 	[*]	This provision is the subject of a Confidential Treatment Request 

  
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amendment, subject to negotiated pricing and delivery terms and conditions for the specific new product. The parties will agree on a schedule for Dell’s
introduction of the new product to Dell’s customers that will include at a minimum the appointment of business and technical contacts for each party to monitor compatibility issues and other product release issues. 
  
  

 Page 6 of 6Amendment to Collaboration Agreement dated January 9, 2004

 Exhibit 10.1 
  
 Confidential treatment has been requested for portions of this exhibit. The copy filed herewith omits the information subject to the
confidentiality request. Omissions are designated as [*]. 
  
 AMENDMENT TO COLLABORATION AGREEMENT 
 BY AND BETWEEN 
 SEATTLE GENETICS, INC. AND PROTEIN DESIGN LABS, INC. 
  
 This Amendment (“Amendment”) effective as of January 9, 2004 modifies and amends the Collaboration Agreement dated as of June 4, 2001
(the “Collaboration Agreement”) by and between Seattle Genetics, Inc., a Delaware corporation (“SGI”), and Protein Design Labs, Inc., a Delaware corporation (“PDL”), as successor in interest to Eos
Biotechnology, Inc. (“Eos”). 
  
 RECITALS

  
 WHEREAS, SGI and Eos entered into a Collaboration
Agreement dated as of June 4, 2001 (the “Collaboration Agreement”) regarding SGI’s antibody-drug conjugate technology. 
  
 WHEREAS, PDL subsequently acquired Eos and assumed Eos’s rights and obligations under the Collaboration Agreement, 
  
 WHEREAS, the parties now wish to amend the Collaboration Agreement on
the terms set forth herein. 
  
 NOW THEREFORE, in
consideration of the promises and of the mutual covenants and agreements herein set forth, the parties agree as follows (with all capitalized terms used but not defined herein having the meanings set forth in the Collaboration Agreement):

  
 1. Definitions and Cross References. Unless
specified herein, each capitalized term shall have the meaning assigned to it in the Collaboration Agreement and each reference to a Section or Article shall refer to the corresponding Section or Article in the Collaboration Agreement. 

 
 1.1 “Cost of Goods” shall mean with respect to Drug
Conjugate Materials manufactured and supplied to PDL (i) if by Third-Parties, [*] in such manufacture and supply of Drug Conjugate Materials; and (ii) if by SGI or its Affiliates, [*] of the consolidated fully burdened cost of
manufacturing and supplying the Drug Conjugate Materials, provided such costs are (i) allocable to the Drug Conjugate Materials being manufactured and supplied by SGI or its Affiliate, (ii) determined in accordance with generally accepted accounting
principles and applied consistently throughout SGI or its Affiliate, as applicable, and (iii) limited to the following factors: [*] 
  
 1.2 “FTE Fees” has the meaning set forth in Section 7.6. 
  
 1.3 “FTE Fees Report” has the meaning set forth in Section 7.6. 
  
 1.4 “Option Period” means, with respect to each Research
Antigen, the period commencing as of the date that [*] thereafter unless terminated earlier pursuant to the provisions of Article 15 herein. 
  

	[*]	Certain information on this page has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the
omitted portions. 

  

 -1- 

 1.5 “PDL Process Invention” means any process invention(s) (whether patentable or
unpatentable) solely invented by PDL’s employees, consultants or contractors and directly arising out of activities conducted under this Agreement, including manufacturing or conjugation processes and/or related analytical methods for
[*]. 
  
 1.6 “Product” means any and all
products where the manufacture, sale or use of such products would have constituted a misappropriation of Drug Conjugation Technology, SGI Know-How, Improvements or New Technologies, and/or an infringement of the Licensed Patents but for the
licenses granted in this Agreement. Notwithstanding the foregoing, for the purposes of [*] under this Agreement only, Product shall not include any products where the manufacture, sale or use of such products would have constituted a
misappropriation of Drug Conjugation Technology, SGI Know-How, Improvements or New Technologies, and/or an infringement of the Licensed Patents, but for the licenses granted in this Agreement, [*]. 
  
 1.7 “Program Inventions” has the meaning set forth in
Section 11.1(a). 
  
 1.8 “Technology Transfer”
has the meaning set forth in Exhibit A to this Amendment. 
  
 1.9 “Third Party ADC Royalties” has the meaning set forth in Section 7.3.2. 
  
 1.10 “Valid Patent Claim” means a claim of an issued and unexpired patent included in Licensed Patents or PDL Patents which has not been
held permanently revoked, unenforceable or invalid by a decision of a court or other governmental agency of competent jurisdiction, unappealable or unappealed within the time allowed for appeal, and which has not been admitted to be invalid or
unenforceable through reissue or disclaimer or otherwise. Notwithstanding the foregoing, for the purposes of [*] under this Agreement only, Valid Patent Claim shall not include any claim of a Licensed Patent that [*]. 
  
 2. Successor-in-Interest. PDL, as successor in interest to the
assets and liabilities of Eos due to a Change in Control (as defined in Article 18 of the Collaboration Agreement), hereby agrees to the terms and conditions of the Collaboration Agreement and assumes all of Eos’ rights and obligations under
the Collaboration Agreement. All references in the Collaboration agreement to Eos Biotechnology, Inc. or “EOS” shall hereinafter refer to Protein Design Labs, Inc. and “PDL.” 
  
 3. Amendments. 
  
 3.1 The first sentence of Section 2.1 of the Collaboration Agreement is
hereby amended to read in its entirety as follows: 
  
 “Subject to the provisions of this Agreement, including the availability of the Antigen pursuant to Section 2.3, PDL may acquire Options pursuant to Section 4.1 for the following number of Research Antigens at any time on or before
[*]:” 
  

	[*]	Confidential treatment has been requested with respect to the omitted portions. 

  

 -2- 

 3.2 Section 3.3 of the Collaboration Agreement is hereby amended to read in its entirety as follows:

  
 “3.3 Term of Research Program. The term of
the Research Program shall expire on [*] (the “Research Program Term”), unless terminated earlier upon termination of this Agreement in accordance with Article 15 hereof.” 
  
 3.3. Section 3.4(d) of the Collaboration Agreement is hereby deleted and
replaced with the following: 
  
 “(d) Upon completion of the
Technology Transfer, PDL shall pay to SGI Five Hundred Thousand Dollars ($500,000.00) by wire transfer of immediately available funds, which payment shall be nonrefundable and non-creditable.” 
  
 3.4. Section 4.2.2 (a) of the Collaboration Agreement is hereby amended to
read in its entirety as follows and a new Section 4.2.2 (d) is hereby added to the Collaboration Agreement to read in its entirety as follows: 
  
 “(a) PDL shall have the right to sublicense the rights granted to PDL pursuant to this Agreement to any Affiliate or any Third-Party with respect to
any Product for which PDL has either marketing rights or has expended material research and/or development effort, subject to the terms and conditions of the SGI In-Licenses attached hereto as Schedule E. Except as otherwise provided herein,
SGI shall only be obligated to provide the Technology Transfer and assistance pursuant to Section 4 of the Amendment and Section 7.6 and Article 13 of the Collaboration Agreement directly to PDL and not to any PDL Sublicensee, provided that, nothing
shall prohibit PDL from disclosing any SGI Confidential Information received during such Technology Transfer or assistance to a Sublicensee in accordance with the provisions of Section 10.2(h) or (i), and provided further that, upon a PDL
Sublicensee’s request, SGI shall provide PDL’s Sublicensees with letters of cross-reference to any SGI drug master files on record with the FDA and the table of contents to such drug master files, as developed. 
  
 “(d) Sublicenses and Sub-Sublicenses. Upon any termination of
this Agreement, all sublicenses and sub-sublicenses validly granted by PDL under this Agreement, to the extent they are consistent with the rights and obligations due SGI hereunder, shall automatically convert to direct licenses between SGI and the
respective Sublicensee; provided that (i) the Sublicensee is not in material breach of the terms of its sublicense at the time of such termination, (ii) upon termination of this Agreement, such Sublicensee agrees in writing to be bound by all terms
of this Agreement applicable to PDL, including the SGI In-Licenses, and can reasonably show the capacity to comply with such terms to the same extent as if such 
  

	[*]	Confidential treatment has been requested with respect to the omitted portions. 

  

 -3- 

 Sublicensee were an original party hereto, (iii) the obligations of SGI under such direct license shall
not be greater than the obligations of SGI under this Agreement, and (iv) the scope of such direct license shall not be broader than the rights sublicensed by PDL to such Sublicensee.” 
  
 3.5. Section 5.2 is hereby amended to read in its entirety as follows:

  
 “The Parties agree that all Drug Conjugation Technology,
SGI Know-How and Drug Conjugate Materials to be transferred to PDL pursuant to this Agreement (“Transferred Technology, Know-How and Materials”), to the extent practicable, shall be so transferred in the form of written memoranda marked
confidential in the case of such Technology and Know-How and, in the case of such Materials, by clearly marked containers. When presented in this manner, these shall be deemed to be “Confidential Information” in accordance with Section
10.1. The foregoing notwithstanding, failure by SGI to present such information in the foregoing manner shall not prevent such information from being deemed “Confidential Information”, provided that, SGI has made a good faith effort to
provide such information pursuant to the requirements set forth in this Section 5.2. PDL will take reasonable and appropriate measures to ensure that the confidentiality of all Transferred Technology, Know-How and Materials is preserved and that the
Transferred Technology, Know-How and Materials are only used for the purposes authorized under the Agreement and in compliance with this Agreement. Failure by SGI to transfer such Transferred Technology, Know-How and Materials in the manner
contemplated in this Section 5.2 will not be construed to limit the license granted to PDL under such SGI Technology pursuant to Sections 2.2 or 4.2 hereof.” 
  
 3.6 The first two sentences of Section 5.3 of the Collaboration Agreement are hereby amended to read as follows: 

 
 “During the term of the Research Program and any subsequent portion
of the Option Period related to a specific Research Antigen, SGI will provide reasonable quantities of Drug Conjugate Materials, including without limitation as described in Exhibits A and B hereto, to PDL at a cost equal to [*] of
SGI’s Cost of Goods. The foregoing notwithstanding, subject to a [*], the pricing for supply of [*] shall be as follows: (a) if SGI supplies [*]; and (b) if SGI supplies [*]. 
  
 If at any time during the term of this Agreement, [*].”

  
 3.7 Section 5.4 of the Collaboration Agreement is hereby
amended such that the designated liaison persons shall be Bill Benjamin and Jeanmarie Guenot for PDL and Shannon Thomas for SGI. Each Party shall be permitted to change its designated liaison person upon notice to the other Party. 
  

	[*]	Confidential treatment has been requested with respect to the omitted portions. 

  

 -4- 

 3.8 Article 6 of the Collaboration Agreement is hereby amended such that all references therein to
“EOS” shall refer to “PDL and/or its Sublicensees.” 
  
 3.9 Section 7.2 of the Collaboration Agreement is hereby amended to increase each of the royalty rates in Sections 7.2(a), (b) and (c) by [*]. 
  

3.10 Section 7.3.2 of the Collaboration Agreement is hereby amended to increase each of the royalty rates in Sections 7.3.2(a), (b) and (c) by
[*]. 
  
 3.11 A new Section 7.3.3 is hereby added to the
Collaboration Agreement to read in its entirety as follows: 
  
 “7.3.3 [*].” 
  
 3.12 Section
7.5(a) of the Collaboration Agreement is hereby amended to read in its entirety as follows: 
  
 “(a) Upon [*];” 
  
 3.13 A new Section 7.6 is hereby added to the Collaboration Agreement as follows: 
  
 “PDL shall pay SGI at an annual rate of [*], up to a maximum of [*], who provide research, development, manufacturing, technology transfer or other assistance to PDL hereunder, including without
limitation as set forth in Section 4 of this Amendment and/or described in Exhibits A and B hereto, as requested by PDL pursuant to this Agreement (the “FTE Fees”). Commencing [*] and upon [*] thereafter, the
FTE Fees will [*]. Within thirty (30) days after the end of each Calendar Quarter, SGI shall submit a report to PDL supporting the calculation of the FTE Fees due for such Calendar Quarter (a “FTE Fees Report”). PDL shall pay
all FTE Fees owed to SGI within thirty (30) days of receipt of each FTE Fees Report.” 
  
 3.14 The first sentence of Section 10.1 of the Collaboration Agreement is hereby amended to read in its entirety as follows: 
  
 “Except as otherwise provided in this Article 10, during the Term and for a period of [*] years thereafter, each Party shall maintain in
confidence, and use only for purposes as expressly authorized and contemplated by this Agreement, all confidential or proprietary information, data, documents or other materials supplied by the other Party under this Agreement and marked or
otherwise identified as “Confidential,” including SGI Know-How, Drug Conjugation Technology, Improvements, New Technologies and information relating to SGI’s and PDL’s respective research programs, development, marketing
and other business practices and finances.” 
  

	[*]	Confidential treatment has been requested with respect to the omitted portions. 

  

 -5- 

 3.15 Section 10.2 of the Collaboration Agreement is hereby amended to read in its entirety as
follows: 
  
 “Notwithstanding the foregoing, the
provisions of Section 10.1 hereof shall not apply to information, documents or materials that the receiving Party can conclusively establish: 
  
 (a) have become published or otherwise entered the public domain other than by acts of the receiving Party or its Affiliates in
contravention of this Agreement; 
  
 (b) are
permitted to be disclosed by prior consent of the other Party; 
  
 (c) have become known to the receiving Party by a Third-Party, provided such Confidential Information was not obtained by such Third-Party directly or indirectly from the other Party under this Agreement on a
confidential basis; 
  
 (d) prior to disclosure
under the Agreement, was already in the possession of the receiving Party, its Affiliates or Sublicensees, provided such Confidential Information was not obtained directly or indirectly from the other Party under this Agreement; 
  
 (e) is disclosed in a press release agreed to by both
Parties hereto, which agreement shall not be unreasonably withheld; and 
  
 (f) are required to be disclosed by the receiving Party to comply with any applicable law, regulation or court order, or are reasonably necessary to obtain patents, copyrights or authorizations to conduct clinical
trials with, and to commercially market Product(s), provided that the receiving Party shall provide prior notice of such disclosure to the other Party and take reasonable and lawful actions to avoid or minimize the degree of disclosure. 

 
 (g) to the extent reasonably needed in a patent
application claiming inventions made hereunder to be filed with the United States Patent and Trademark Office and/or any similar foreign agency, provided that the receiving party shall provide prior notice of such disclosure to the other Party and
take reasonable and lawful actions to avoid or minimize the degree of disclosure; 
  
 (h) by PDL to a Sublicensee as permitted hereunder, provided that such Sublicensee be subject to obligations of confidentiality
substantially similar to those contained herein; and 
  

 -6- 

 (i) by PDL to a bona fide collaborator or manufacturing, development or sales partner,
but only to the extent reasonably relevant to the collaboration or partnership and provided that such collaborator or partner be subject to obligations of confidentiality substantially similar to those contained herein. 
  
 3.16 Section 10.3 is hereby amended to read in its entirety as follows:

  
 “PDL and SGI shall not disclose any terms or conditions
of this Agreement to any Third-Party without the prior consent of the other Party, other than to Sublicensees or prospective Sublicensees subject to obligations of confidentiality substantially similar to those contained herein, or as required by
applicable laws, regulations or a court order (and in any such case the disclosing Party shall provide notice to the other Party and takes reasonable and lawful actions to avoid or minimize the degree of such disclosures).” 
  
 3.17 Section 11.1 is hereby amended to read in its entirety as follows:

  
 “(a) Each Party shall promptly disclose
to the other Party the making, conception or reduction to practice of any inventions directly arising out of activities conducted under this Agreement (“Program Inventions”). 
  
 (b) “[*] shall own all Program Inventions that
(i) are invented solely by one or more employees, agents or consultants of [*] and do not primarily relate to the [*] or (ii) are invented solely or jointly by employees, agents or consultants of [*] and/or [*] and
primarily relate to [*]. To the extent that any such Program Inventions relating primarily to a [*] shall have been invented by [*] and are owned by [*], [*] hereby assigns all of its right, title and interest
therein to [*]. 
  
 (c) [*] shall
own all Program Inventions that (i) are invented solely by one or more employees, agents or consultants of [*] and do not primarily relate to [*] or (ii) are invented solely or jointly by employees, agents or consultants of [*]
and/or [*] and primarily relate to the [*]. To the extent that any Program Inventions relating primarily to [*] shall have been invented by [*] and are owned by [*], [*] hereby assigns all of its right,
title and interest therein to [*]. [*] also hereby assigns all of its right, title and interest in all [*] Process Inventions to [*]. 
  
 (d) Except as set forth in Sections 11.1(b) and 11.1(c), [*]. 
  
 (e) Inventorship, for the purposes of this Agreement, shall
be determined in accordance with U.S. patent law.” 
  

	[*]	Confidential treatment has been requested with respect to the omitted portions. 

  

 -7- 

 3.18 Article 13 of the Collaboration Agreement is hereby amended to read in its entirety as follows:

  
 “Should PDL develop an ADC for clinical development, SGI
will provide to a reasonable extent, at PDL’s request, technical information required for regulatory filings. This information will include, as available, Chemistry Manufacturing and Controls documentation, other toxicity and safety data,
access to any drug master files on record with the FDA and any other relevant materials. PDL shall reimburse SGI for any out-of-pocket costs incurred by SGI in providing such information plus SGI’s fully-burdened FTE rate as set forth in
Section 7.6.” 
  
 3.19 A new Section 14.1(f) is hereby added
to the Collaboration Agreement to read in its entirety as follows: 
  
 “(f) SGI represents and warrants that the SGI Technology constitutes all of the patents, patent applications and know-how owned or controlled by SGI with the right to grant sublicenses as of the Effective Date that relate to the Drug
Conjugation Technology.” 
  
 3.20 Section 15.3 of the
Collaboration Agreement is hereby amended to read in its entirety as follows: 
  
 “PDL shall promptly give SGI notice if PDL or its Sublicensee intends to abandon permanently the commercial development of any Exclusive Antigen, whereupon any Exclusive License with respect to such Exclusive
Antigen shall automatically terminate and all rights related to the use of SGI Technology in connection with the Exclusive Antigen shall revert back to SGI.” 
  
 3.21 A new sentence is hereby added to the end of Section 15.4 of the Collaboration Agreement to read in its entirety as
follows: 
  
 “In addition, to the extent permitted under
applicable law, the license granted under this Agreement may be terminated as to any country by SGI upon [*] prior written notice in the event that PDL challenges a Licensed Patent in that country.” 
  
 3.22 Section 15.7.1 of the Collaboration Agreement is hereby deleted and
replaced with the following: 
  
 “Except where explicitly
provided within this Agreement, termination of this Agreement for any reason, or expiration of this Agreement, will not affect any: (i) obligations, including payment of any royalties or other sums which have accrued as of the date of termination or
expiration, and (ii) rights and obligations which, from the context thereof, are intended to survive termination or expiration of this Agreement, including provisions of Articles 10, 11, 12, 16 and 22, and Sections 4.2.2(d), 8.2, 8.3, 15.6 and 15.7,
which shall survive the expiration or termination of the Agreement. Notwithstanding the foregoing, all licenses granted by SGI to PDL hereunder, including all Exclusive Licenses, will immediately terminate upon termination of this Agreement pursuant
to Section 15.2, Section 15.4 or Section 15.5.” 
  

	[*]	Confidential treatment has been requested with respect to the omitted portions. 

  

 -8- 

 3.23 A new Section 15.7.3 is hereby added to the Collaboration Agreement to read in its entirety as
follows: 
  
 “All right and licenses granted under or
pursuant to this Agreement by SGI to PDL are, and shall otherwise be deemed to be, for purposes of Section 365(n) of the U.S. Bankruptcy Code, licenses of rights to “intellectual property” as defined under Section 101(52) of the U.S.
Bankruptcy Code. The parties agree that PDL, as a licensee of such rights under this Agreement, shall retain and may fully exercise all of its right and elections under the U.S. Bankruptcy Code, subject to performance by PDL of its preexisting
obligations under this Agreement.” 
  
 3.24 The last sentence
of Section 16.2 of the Collaboration Agreement shall be amended to read in its entirety as follows: 
  
 “Any settlement of a Liability for which any Indemnitee seeks to be reimbursed, indemnified, defended or held harmless under this Article 16 shall be
subject to prior consent of such Indemnitee, such consent not to be unreasonably withheld.” 
  
 3.25 The notice provisions for PDL set forth in Article 22 of the Collaboration Agreement shall hereafter be: 
  
 “If to Protein Design Labs, Inc.: 
 Protein Design Labs, Inc 
 34801 Campus Drive
Fremont, CA 94555 
 Phone: (501) 547-1400 
 Attention: Chief Executive Officer 
  
 With copy to 
 Protein Design Labs, Inc 
 34801 Campus Drive Fremont, CA 94555 
 Phone: (501) 547-1400 
 Attention: General Counsel” 
  
 3.26 Schedule B to the Collaboration Agreement is hereby superseded and replaced by Schedule B attached to this Amendment. 
  
 3.27 Schedule C to the Collaboration Agreement is hereby superseded
and replaced by Schedule C attached to this Amendment. 
  

 -9- 

 4. Technology Transfer and Development Assistance. During the Research Program, SGI shall
disclose and transfer to PDL all SGI Know-how, New Technologies and Improvements as are reasonably necessary for PDL or its designee to manufacture Drug Conjugate Materials for any and all Antibodies. Specifically, SGI will use reasonable commercial
efforts to conduct the Technology Transfer as described in Exhibit A by [*]. In addition, during the Research Program Term, SGI will provide assistance (which may include the transfer of additional SGI Know-how, New Technologies and
Improvements to the extent such SGI Know-how, New Technologies and/or Improvements were not previously transferred to PDL pursuant to Exhibit A) to PDL regarding preclinical development and manufacturing of Products including, but not limited
to, the assistance described in Exhibit B, subject to PDL’s payment of FTE Fees for such assistance at the rates set forth in Section 7.6 of the Collaboration Agreement. During the term of this Agreement, but after expiration or
termination of the Research Program, SGI will continue to provide PDL with reasonable consultation and assistance concerning development and manufacturing of Products as mutually agreed between the parties, including without limitation pursuant to
Sections 5.3 and Article 13 of the Collaboration Agreement, subject to PDL’s payment of FTE Fees for such assistance at the rates set forth in Section 7.6 of the Collaboration Agreement. This Section 4 shall supersede and replace Section 5.1 of
the Collaboration Agreement. 
  
 5. PDL Patent License and
Patent Rights Agreements. Concurrent herewith, the parties are entering into agreements to provide SGI with a license and options to obtain licenses to PDL’s antibody humanization technology in the forms attached hereto as Exhibit
C. 
  
 6. No Other Amendments. Except as
expressly set forth herein, the Collaboration Agreement remains in full force and effect in accordance with its terms and nothing contained herein shall be deemed (i) a waiver, amendment, modification or other change of any term, condition or
provision of the Collaboration Agreement or any agreement entered into pursuant to the Collaboration Agreement (or a consent to any such waiver, amendment, modification or other change), (ii) a consent to any transaction or (iii) to prejudice any
right or rights which SGI and PDL may have under the Collaboration Agreement and/or any agreement entered into in connection therewith. On and after the date hereof, each reference in the Collaboration Agreement to “this Collaboration
Agreement,” “hereunder,” “hereof,” or words of like import referring to the Collaboration Agreement, shall mean and be a reference to the Collaboration Agreement as amended hereby. 
  
 7. Further Assurances. The parties hereto agree to take such
further acts, to do such things, and to execute and deliver such additional conveyances, assignments, agreements and instruments, as may be reasonably requested in connection with the administration and enforcement of this Amendment and to permit
the exercise thereof in compliance with any applicable laws. 
  
 8. Headings. The headings used herein are for convenience of reference only and shall not affect the construction of, nor shall they be taken into consideration in interpreting, this Amendment. 
  

	[*]	Confidential treatment has been requested with respect to the omitted portions. 

  

 -10- 

 9. Counterparts. This Amendment may be executed in any number of separate counterparts,
each of which shall be an original and all of which taken together shall constitute one and the same instrument. 
  
 10. Applicable Law. This Amendment shall be governed by, and construed and interpreted in accordance with, the laws of the State of
Washington, without regard to the conflict of law principles thereof.  
  
 [Signature page follows] 
  

 -11- 

 IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed and delivered as of
the day and year first above written. 
  

			
	SEATTLE GENETICS, INC.
		
	 By:
	 	 /s/    Clay B. Siegall

	 	 	 Name:     Clay B. Siegall

	 	 	 Title:       President and CEO

	
	PROTEIN DESIGN LABS, INC.
		
	 By:
	 	 /s/    Mark McDade

	 	 	 Name:    Mark McDade

	 	 	 Title:      CEO

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