Document:

EX-10.1

 CERTAIN IDENTIFIED INFORMATION HAS BEEN EXCLUDED FROM THIS EXHIBIT BECAUSE IT IS BOTH
(I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. SUCH INFORMATION HAS BEEN MARKED HEREIN WITH [***]. 

Exhibit 10.1 
 AMENDMENT
NO. 1 
 TO DEVELOPMENT, LICENSE AND COMMERCIALIZATON AGREEMENT 

This Amendment No. 1 to the Development, License and Commercialization Agreement (this “Amendment”) is made and entered into as of
March 20, 2019 (the “Amendment Effective Date”) by and between Endo Ventures Limited, an Irish company with an office located at First Floor, Minerva House, Simmonscourt Road, Ballsbridge, Dublin 4, Ireland
(“EVL”), and Catalyst Pharmaceuticals, Inc., a Delaware corporation with an office located at 355 Alhambra Circle, Suite 1250, Coral Gables, FL 33134, USA (“Catalyst”). 

WHEREAS, EVL and Catalyst entered into that certain Development, License and Commercialization Agreement dated December 18, 2018 (the
“Agreement”) regarding development and commercialization of Vigabatrin tablets; 
 WHEREAS, effective December 24, 2018,
Catalyst transferred and conveyed to EVL all of Catalyst’s right, title, interest, ownership, and control of the [***]; and  
 WHEREAS,
EVL and Catalyst now desire to, as of the Amendment Effective Date, amend the Agreement as further set forth below. 
 NOW, THEREFORE, in
consideration of the mutual covenants contained herein, the parties agree as follows: 
 1. Definitions. All capitalized terms used in this Amendment
and not otherwise defined herein shall have the meanings given to them in the Agreement. 
 2. Amendment. As of the Amendment Effective Date,
Section 6.1.1 of the Agreement shall be deleted in its entirety and replaced with the following: 
 “Royalty Rates. EVL
shall pay to Catalyst a royalty (the “Royalty”) equal to [***]% of the Net Profits accruing during the Term; provided, however, in the event that the Net Profits reach [***] in the aggregate, upon such date, the Royalty shall thereafter
equal [***]% of the Net Profits. For the avoidance of doubt, the Calendar Quarter in which the [***] amount is reached shall be subject to two separate Royalty rates: (i) a [***]% Royalty with respect to the amounts of the Net Profits less than
[***], and (ii) a [***]% Royalty with respect to the amounts of the Net Profits equal to or greater than [***].” 
 3. No Other Effect.
Except as expressly modified hereby, the Agreement remains in full force and effect. 
 4. Counterparts. The parties may execute this Amendment in
counterparts, each of which is deemed an original, but all of which together constitute one and the same agreement. This Amendment may be delivered by facsimile transmission, by electronic mail in “portable document format”
(“.pdf”), or by any other electronic means intended to preserve the original graphic and pictorial appearance of a document, and such copies of executed signature pages shall be binding as originals. 

[SIGNATURE PAGE FOLLOWS] 

  
 Page 1 of 2 

 Each of the parties hereby indicates its acceptance of the terms hereof by the signature hereto of a duly
authorized representative. 
  

									
	ENDO VENTURES LIMITED	 		 	            CATALYST PHARMACEUTICALS, INC.

									
					
	By:	 	/s/ Rahul Garella	 		 	By:	 	/s/ Patrick J. McEnany
					
	Name:	 	Rahul Garella	 		 	Name:	 	Patrick J. McEnany
					
	Title:	 	SVP International Pharmaceuticals	 		 	Title:	 	CEO

  
 Page 2 of 2Exhibit 10.1

 

Engagement Agreement

 

This Engagement is signed by the two parties:

 

Name of party A: LAW Insurance Broker Co.,
Ltd. (hereinafter referred to as “Party A”)

Registered address: 5F, No. 311, Nanjing
E. Rd., Songshan Dist., Taipei City, Taiwan

Postcode: 10595

 

Name of party B: Lee, Shu-Fen

ID No.: M221052909

 

Party A and party B shall reach following
agreements:

 

		1.	Term and Position of Employment

 

Party A appoints Party B as
a senior management personnel of Party A (position: Chairwoman), the term of employment is from December 21th,
2018 to December 20th, 2021.

 

		2.	Job description

 

Party B shall assist
Party A in operating and managing insurance agency businesses during her term of employment, including but not limited to the following
matters:

 

		(1)	Business and administration planning.

 

		(2)	Execution of resolution of the shareholders' meeting
or the board of directors.

 

		(3)	The appointment and dismissal of company employees and
salesmen, except for internal auditors.

 

		(4)	Execute company's financial management and use (the amount
of NT) forty-five million or less at Party B’s discretion.

 

		(5)	As the representatives (including the need to act as
in writing (such as signing or any issue of official letters) and personal behaviors without written documents (such as participation
in a meeting or event).

 

		(6)	Other matters assigned by the Board of Directors of Party
A.

 

    	 

    

    

 

		3.	Remuneration and Condition of employment

 

		(1)	Salary: Party A shall pay NT$ 300,000 to party B as the
salary each month on fifth day of each calendar month. For less than one month, the Party A shall pay as one month.

 

		(2)	Managerial allowance: NT$ 100,000 per month.

 

		(3)	Bonus

 

Based on 1.25% of Party A’s
income after tax

 

Each year, the Party A will remit
such bonus to the designated bank account of Party B within five working days after the financial report is acknowledged by the
shareholders' meeting of Party A.

 

		(4)	Year-end Bonus

 

Party A should pay the Party
B three times of the monthly salary as the year-end bonus when Party A pays the employee's year-end bonus to its employees every
year.

 

In order to promote the effectiveness
of Party B in handling the appointment set forth in Article 2, Party A agrees to provide Party B with a special amount of NT$ 100,000
per month. The fee shall be used and paid in accordance with the Article 3 (1), but Party B shall provide the documents or invoices
for reimbursement.

 

		4.	Special Provision

 

Party A agrees to provide Party
B following benefits in the period of engagement:

 

		(1)	Labor insurance;

 

		(2)	Health Insurance;

 

		(3)	Group insurance (the premium will be in accordance with
the negotiation between the Party A and insurance company);

 

		(4)	Domestic and foreign studies (unlimited domestic and
one time for foreign);

 

		(5)	Travelling (20 days for foreign, seven days 2 times in
domestic);

 

		(6)	General health examination (once a year, and with a (PET)
photographic examination during the engagement.); and

 

		(7)	Other benefits according to the Labor Standards Act or
related regulations, including but not limited to, Severance compensation, workers' compensation or labor pension.

 

    	 

    

    

 

		5.	Obligations of Party B

 

Party B shall be under the care
of a good manager, take care of the Party A’s affairs with proper implementation and bear the following obligations during
the engagement period:

 

		(1)	During the engagement period and two years after termination
shall not be appointed as the party of business and others engaged in the same or similar nature of the business as the Party
A, but only in the Taiwan Area is limited.

 

		(2)	Fulfill the obligation to protect the equipment (including
software and hardware) of Party A.

 

		(3)	In the event of a major incident on company operations,
shall immediately report to the Board to discuss the solutions.

 

		(4)	Execute the matters relating to the bounden duty of the
chairwoman to perform the Companies Act, the Insurance Act or related regulations.

 

		6.	Obligations of Party A

 

During the term of this Engagement, the
Party shall:

 

(1) In accordance with the provisions of
Article 3, Party B shall be given remuneration as scheduled and in full.

 

(2) In accordance with the provisions of
Article 4, the implementation of various welfare measures.

 

(4) At the request of Party B, provide
the necessary equipment for the execution of the appointment.

 

    	 

    

    

 

		7.	Termination

 

This Engagement shall be terminated
upon the expiration of this Engagement except the following conditions:

 

		(1)	This Engagement shall be terminated once re-election
of all directors and supervisors of Party A.

 

		(2)	In the event that Party B disqualifies to act as the
chairwoman, this Engagement shall be terminated.

 

		(3)	Due to personal physical factors have been diagnosed
by doctors and Party B is unable to act as the chairwoman, Party B may terminate this Engagement at any time after notifying Party
A.

 

		(4)	Party A decides to close the business, merge or make
with 1/2 or more of its businesses or other capital to any third party, this Engagement shall be terminated.

 

		(5)	Party B may notify Party A in writing to terminate this
Engagement in writing more than one month in advance.

 

Except the above articles for
terminating this Engagement, either party may claim damages incurred by any termination of this Engagement or refuse to fulfill
the contractual obligations.

 

		8.	Non-assignment

 

Either party may not assign
or transfer this Engagement, in whole or in part, by operation of law or otherwise, without the other party’s express prior
consent.

 

		9.	General Provisions

 

		(1)	In the event any matter or the interpretation of this
Engagement is doubtful, the parties shall settle in accordance with the principle of good faith in addition to the provisions
of the civil law, company law, insurance law or relevant laws and regulations.

 

		(2)	Any waiver, modification, addendum or amendment of any
provision of this Engagement will be effective only if in writing and signed by duly authorized representatives of each party.

 

		(3)	All disputes arising out or in connection with this Engagement
shall be settled by the first instance of the District Court of Taipei, Taiwan, Republic of China.

 

This Engagement may be executed in counterparts,
each of which will be deemed an original, but all of which together will constitute one and the same instrument.

 

In case this Engagement is contraindicated
to previous verbal and written agreements, this Engagement shall be applied. Any modification of this Engagement s must adopt each
party's agreement in written.

 

	
        Party A: LAW Insurance Broker Co., Ltd.

        legal representative or principal (sealed
        by):

         
	Party B (Sealed by):  Lee, Shu-Fen
	Date:  December 21th, 2018	Date:  December 21th, 2018

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