Document:

PROMISSORY NOTE

Vancouver,  British  Columbia
April  24,  2000
                                                                    $US50,000.00

     FOR  VALUE RECEIVED, the undersigned promises to pay to the order of Herman
Poon,  the  principal  sum  of  Fifty  Thousand  Dollars ($US50,000.00) in legal
tender.  Payment  shall  be  made  upon  the successful completion of an initial
public  offering  of  the  common  stock  of  Lifestream  Inc.  and  sale of all
registered  shares  pursuant  to  such  offering.

     1.     Default.     If  any  payment  is  not paid when due, or if Obligors
            -------
breach  any  other  agreement  with the holder of this note, Obligors will be in
default.  Upon  default, the holder may declare the unpaid principal balance and
all  accrued  interest  and  unpaid  late  charges,  if any, immediately due and
payable,  without  notice,  and  Obligors  will  then  pay  that  amount.

          The holder may employ attorneys or other agents to collect amounts due
under  this note if Obligors are in default or to otherwise enforce the terms of
this  note  and  any agreement securing this note, and Obligors agree to pay all
fees,  costs  and expenses incurred by the holder as a consequence of default by
Obligors.  Such  fees, costs and expenses include attorneys' fees whether or not
litigation  is  commenced and including any appeal, fees or expenses incurred in
any  bankruptcy,  receivership, or other insolvency proceedings, any anticipated
post-judgment  collection  charges, and all other costs of collection, including
court  costs.  The  holder may delay enforcing any of its rights under this note
without  forfeiting  such  rights.

     2.     Waiver.     The  Obligors hereby severally waive presentment, demand
            ------
for  payment,  protest, notice of nonpayment or dishonor, and any relief, waiver
or  discharge  arising from any extension of time for payment granted before, at
or  after  maturity,  or  for  any  other  causes.

     3.     Obligors.     "Obligors"  as  used  in  this  note means all makers,
            --------
signers  and  co-signers,  guarantors,  sureties,  and  endorsers.

                                            /s/  Lifestream  Inc.
                                            ------------------------------------
                                            Lifestream  Inc.

<PAGE><PAGE>

                         REGISTRATION RIGHTS AGREEMENT
                         -----------------------------

          This Registration Rights Agreement (this "Agreement") is made and
                                                    ---------
entered into as of August 22, 2000, among Orthovita, Inc., a Pennsylvania
corporation (the "Company"), Brown Simpson Partners I, Ltd. (the "Purchaser"),
                  -------                                         ---------
Janney Montgomery Scott LLC ("Janney") and Emerging Growth Equities, Ltd. and
its designee, VFT Special Ventures Ltd. ("EGE" and collectively with Janney, the
"Placement Agents").

          This Agreement is made pursuant to the Subscription Agreement, dated
as of the date hereof between the Company and the Purchaser (the "Purchase
                                                                  --------
Agreement") and the Placement Agents Agreement dated as of the date hereof among
---------
the Company and the Placement Agents.

          The Company, the Purchaser and the Placement Agents hereby agree as
follows:

     1.   Definitions.
          -----------

          Capitalized terms used and not otherwise defined herein shall have the
meanings given such terms in the Purchase Agreement. As used in this Agreement,
the following terms shall have the following meanings:

          "Advice" has the meaning set forth in Section 3(o) hereof.
           ------

          "Affiliate" means, with respect to any Person, any other Person that
           ---------
directly or indirectly controls or is controlled by or under common control with
such Person.  For the purposes of this definition, "control", when used with
                                                    -------
respect to any Person, means the possession, direct or indirect, of the power to
direct or cause the direction of the management and policies of such Person,
whether through the ownership of voting securities, by contract or otherwise;
and the terms "affiliated", controlling" and "controlled" have meanings
               ----------   -----------       ----------
correlative to the foregoing.

          "Business Day" means any day except Saturday, Sunday and any day which
           ------------
shall be a legal holiday or a day on which banking institutions in the State of
New York generally are authorized or required by law or other government action
to close.

          "Closing" shall mean the Closing as defined in the Purchase Agreement.
           -------

          "Commission" means the Securities and Exchange Commission.
           ----------

          "Common Stock" means the Company's common stock, par value $0.01 per
           ------------
share.

          "Effectiveness Date" means the date on which the Commission declares
           ------------------
the Registration Statement effective.
<PAGE>

          "Effectiveness Period" has the meaning set forth in Section 2(a)
           --------------------
hereof.

          "Event" has the meaning set forth in Section 2(b) hereof.
           -----

          "Exchange Act" means the Securities Exchange Act of 1934, as amended.
           ------------

          "Filing Date" means as soon as practicable after the Closing but in no
           -----------
event later than the 45th day following the Closing.

          "Holder" or "Holders" means the holder or holders, as the case may be,
           ------      -------
from time to time of Registrable Securities.

          "Indemnified Party"  has the meaning set forth in Section 5(c) hereof.
           -----------------

          "Indemnifying Party" has the meaning set forth in Section 5(c) hereof.
           ------------------

          "Initial Registration Statement" has the meaning set forth in Section
           ------------------------------
2(a) hereof.

          "Losses" has the meaning set forth in Section 5(a) hereof.
           ------

          "Majority Holders" means the Holders of at least fifty percent (50%)
           ----------------
of the Registrable Securities.

          "National Market" means the NASDAQ National Market, the NASDAQ
           ---------------
SmallCap Market, the New York Stock Exchange or the American Stock Exchange.

          "Person" means an individual or a corporation, partnership, trust,
           ------
incorporated or unincorporated association, joint venture, limited liability
company, joint stock company, government (or an agency or political subdivision
thereof) or other entity of any kind.

          "Purchase Rights" means the rights of the Purchaser to purchase
           ---------------
additional shares of Common Stock after the Closing pursuant to Section 1.4 of
the Purchase Agreement.

          "Proceeding" means an action, claim, suit, arbitration, investigation
           ----------
or proceeding (including, without limitation, an investigation or partial
proceeding, such as a deposition), whether commenced or threatened.

          "Prospectus" means the prospectus included in the Registration
           ----------
Statement (including, without limitation, a prospectus that includes any
information previously omitted from a prospectus filed as part of an effective
registration statement in reliance upon Rule 430A promulgated under the
Securities Act), as amended or supplemented by any prospectus supplement, with
respect to the terms of the offering of any portion of the Registrable
Securities covered by the Registration Statement, and all other amendments and
supplements to the Prospectus, including post-effective amendments, and all
material incorporated by reference in such Prospectus.
<PAGE>

          "Registrable Securities" means the shares of Common Stock (i) issued
           ----------------------
or issuable with respect to the Purchase Agreement (including any shares of the
Company's capital stock issued with respect to the Purchase Rights) or (ii)
issuable upon exercise of or with respect to the Warrants and shall include any
shares of the Company's capital stock issued with respect to the Warrant as a
result of any stock split, stock dividend, recapitalization, exchange or similar
event or otherwise.

          "Registration Delay Payment" has the meaning set forth in Section 2(b)
           --------------------------
hereof.

          "Registration Statement" means the Initial Registration Statement and
           ----------------------
any additional registration statements contemplated herein, including (in each
case) the Prospectus, amendments and supplements to such registration statement
or Prospectus, including pre- and post-effective amendments, all exhibits
thereto, and all material incorporated by reference in such registration
statement.

          "Rule 144" means Rule 144 promulgated by the Commission pursuant to
           --------
the Securities Act, as such Rule may be amended from time to time, or any
similar rule or regulation hereafter adopted by the Commission having
substantially the same effect as such Rule.

          "Rule 158" means Rule 158 promulgated by the Commission pursuant to
           --------
the Securities Act, as such Rule may be amended from time to time, or any
similar rule or regulation hereafter adopted by the Commission having
substantially the same effect as such Rule.

          "Rule 415" means Rule 415 promulgated by the Commission pursuant to
           --------
the Securities Act, as such Rule may be amended from time to time, or any
similar rule or regulation hereafter adopted by the Commission having
substantially the same effect as such Rule.

          "Securities Act" means the Securities Act of 1933, as amended.
           --------------

          "Special Counsel" means one special counsel to the Holders.
           ---------------

          "Trading Day" means a day on which the National Market on which the
           -----------
Common Stock is then listed is open for trading.

          "Warrants" means the warrants issuable to the Purchaser pursuant to
           --------
the Purchase Agreement, and the warrants issuable to each of the Placement
Agents pursuant to the Placement Agents Agreement.

     2.   Registration Requirements.
          -------------------------

          (a)  Filing and Effectiveness Obligations. On or prior to the Filing
               ------------------------------------
Date, the Company shall prepare and file with the Commission a Registration
Statement (the "Initial Registration Statement") which shall cover all
                ------------------------------
Registrable Securities for an offering to be made on a continuous basis pursuant
to a "Shelf" registration statement under Rule 415. The Initial Registration
Statement shall be on Form S-3 or any successor form (except if the Company is
not then eligible to register for resale the Registrable Securities on Form S-3,
in which case such registration shall be on Form S-1 or any successor form. The
Company shall use its best efforts
<PAGE>

to cause the Initial Registration Statement to be declared effective under the
Securities Act as promptly as possible after the filing thereof, and to keep
such Initial Registration Statement continuously effective under the Securities
Act (subject to Section 3(r)) from the Effectiveness Date until the date when
all Registrable Securities covered by such Initial Registration Statement have
been sold or may be sold without volume restrictions pursuant to Rule 144 as
determined by counsel to the Company pursuant to a written opinion letter,
addressed to the Holders and the Company's transfer agent to such effect (the
"Effectiveness Period"). The number of shares of Common Stock initially included
 --------------------
in the Initial Registration Statement shall be no less than 100% of the sum of
the number of shares of Common Stock that are issued at the Closing pursuant to
the Subscription Agreement and issuable pursuant to the exercise of the
Warrants, without regard to any limitation on the Holder's ability to exercise
the Warrants, and any Dilution Shares issued prior to the filing of the Initial
Registration Statement.

          (b)  Penalties.  If (i) the Initial Registration Statement covering
               ---------
all the applicable Registrable Securities and required to be filed by the
Company pursuant to this Agreement is not filed with the Commission on or before
the Filing Date, (ii) the Company fails to respond, in a commercially reasonable
manner, to any comments made by the Commission with respect to the Initial
Registration Statement within ten (10) Business Days following the receipt
thereof, or (iii) on any day after the Registration Statement has been declared
effective by the Commission (A) sales of all the Registrable Securities required
to be included on a Registration Statement cannot be made pursuant to the
Registration Statement because of a failure to keep the Registration Statement
effective, to disclose such information as is necessary for sales to be made
pursuant to the Registration Statement, or to register sufficient shares of
Common Stock, but excluding any "black-out periods" pursuant to Section 3(r)
hereof) or (B) the Common Stock is not listed or included for quotation on a
National Market after being so listed or included for quotation (each such event
specified in (i), (ii), (iii) and (iv) above, an "Event"), then, as partial
                                                  -----
relief for the damages to any Holder by reason of any such delay in or reduction
of its ability to sell the Registrable Securities (which remedy shall not be
exclusive of any other remedies available at law or in equity), the Company
shall pay to each Holder, upon the occurrence of each such violation, an amount
(a "Registration Delay Payment") equal to the product of (a) the purchase price
    --------------------------
of such Holder's Common Stock and Warrants (as set forth in the Purchase
Agreement) then owned beneficially and of record by the Purchaser or an
Affiliate of the Purchaser, (b) (.020) and (c) the number of months (rounded up
to the nearest whole month in the event of partial months) that such Event has
occurred and is continuing, provided, however, that there shall be excluded from
                            --------  -------
such period any delays which are solely attributable to changes required by the
Holders in the Registration Statement with respect to information relating to
the Holders, to the failure of the Holders to conduct their review of the
Registration Statement pursuant to Section 3(a), or to the failure to include in
a Registration Statement Registrable Securities issued or issuable pursuant to
Sections 5 or 13 of the Purchaser's Warrant or pursuant to Section 1.4 of the
Purchase Agreement, unless the Company has failed to timely file an amendment to
a Registration Statement including such Registrable Securities in accordance
with Section 3(b) hereof. The Company shall pay such Registration Delay Payments
to each Holder in shares of Common Stock on the last Business Day of each month
during which an Event has occurred and is continuing. For the purposes of this
Section 2, the value of the Common Stock shall equal: (i) the average closing
bid price of the Common Stock as reported on the National Market for each of the
five Trading Days immediately preceding the date on which the Registration Delay
Payment is due or paid, or (ii) if the Common Stock is not then publicly
<PAGE>

traded, the fair market value of a share of Common Stock as determined by a
nationally recognized or major regional investment banking firm or firm of
independent certified public accountants (the "Appraiser") selected in good
faith by the registered owners of a majority of the Registrable Securities;
provided, however, that, after receipt of the determination by such Appraiser,
the Company shall have the right to select, in good faith, an additional
Appraiser, in which case the fair market value shall be equal to the average of
the determinations by each such Appraiser; and provided further that all
determinations of the value of the Common Stock pursuant to this Section 2 shall
be appropriately adjusted for any stock dividends, stock splits or other similar
transactions during such period.  In the event the Company fails to make a
Registration Delay Payment within ten (10) Business Days of the date such
Registration Delay Payment is due, such Registration Delay Payment shall bear
interest at the rate of 2.0% per month (rounded up to the nearest whole month in
the event of partial months) until paid in full.

     3.   Registration Procedures.
          -----------------------

          In connection with the Company's registration obligations hereunder,
the Company shall:

     (a)  Preparation of Registration Statement.  Prepare and file with the
          -------------------------------------
Commission on or prior to the Filing Date a Registration Statement on Form S-3
or its successor (or, if the Company is not then eligible to register the resale
of the Registrable Securities on Form S-3, the Registration Statement shall be
made on Form S-1 or its successor form) (which shall include a Plan of
Distribution substantially in the form of Exhibit A annexed hereto, and use best
                                          ---------
efforts to cause the Registration Statement to become effective and remain
effective as provided herein; provided, however, that not less than three (3)
                              --------  -------
Business Days prior to the filing of the Registration Statement or any related
Prospectus or any amendment or supplement thereto (including any document that
would be incorporated therein by reference), the Company shall, if reasonably
practicable (i) furnish to the Holders and their Special Counsel, copies of all
such documents proposed to be filed (including documents incorporated by
reference), which documents will be subject to the review of such Holders and
their Special Counsel, and (ii) cause its officers and directors, counsel and
independent certified public accountants to respond to such inquiries as shall
be necessary, in the reasonable opinion of the Special Counsel to such Holders,
to conduct a reasonable investigation within the meaning of the Securities Act.
The Company shall not be restricted in any manner from including within the
Registration Statement the distribution, issuance or resale of any of its or any
other securities, on its own behalf or on behalf of any of the Company's
stockholders.  The Company shall not file the Registration Statement or any such
Prospectus or any amendments or supplements thereto to which the Majority
Holders or their Special Counsel shall reasonably object.  The sections of such
Registration Statement covering information with respect to the Holders, the
Holders' beneficial ownership of securities of the Company or the Holders'
intended method of disposition of Registrable Securities shall conform to the
information provided to the Company by each of the Holders.

          (b)  Amendments.  (i)  Prepare and file with the Commission, in
               ----------
accordance with the requirements and in the time periods set forth in the
Securities Act, such amendments, including post-effective amendments, to the
Registration Statement as may be necessary to keep the Registration Statement
continuously effective for the Effectiveness Period and prepare and file with
the Commission such additional Registration Statements as are required to be
filed
<PAGE>

hereunder in order to register for resale under the Securities Act all of the
Registrable Securities, (ii) cause the related Prospectus to be amended or
supplemented by any required Prospectus supplement, and as so supplemented or
amended to be filed pursuant to Rule 424 (or any similar provisions then in
force) promulgated under the Securities Act, (iii) respond as promptly as
possible to any comments received from the Commission with respect to the
Registration Statement or any amendment thereto and as promptly as practicable,
but in no event later than ten (10) Business Days after receipt thereof, and as
promptly as possible provide the Holders true and complete copies of all
correspondence from and to the Commission relating to the Registration
Statement, and (iv) comply in all material respects with the provisions of the
Securities Act and the Exchange Act with respect to the disposition of all
Registrable Securities covered by the Registration Statement during the
applicable period in accordance with the intended methods of disposition by the
Holders thereof set forth in the Registration Statement as so amended or in such
Prospectus as so supplemented. In the event the number of shares available under
a Registration Statement filed pursuant to this Agreement is insufficient to
cover 100% of the Registrable Securities issued or issuable upon exercise of the
Warrants or the Purchase Rights, the Company shall amend the Registration
Statement, or file a new Registration Statement (on the short form available
therefor, if applicable), or both, so as to cover 100% of the Registrable
Securities, in each case as soon as practicable, but in any event within twenty
(20) Business Days after the necessity therefor arises. The Company shall use
its best efforts to cause such amendment and/or new Registration Statement to
become effective as soon as practicable following the filing thereof.

          (c)  Notifications.  Notify the Holders of Registrable Securities to
               -------------
be sold and their Special Counsel, as promptly as possible (and, in the case of
(i)(A) below, not less than five (5) days prior to such filing and, in the case
of (i)(C) below, not later than the first Business Day after effectiveness)
following the day (i) (A) when a Prospectus or any Prospectus supplement or
post-effective amendment to the Registration Statement is proposed to be filed,
(B) when the Commission notifies the Company whether there will be a "review" of
such Registration Statement and whenever the Commission comments in writing on
such Registration Statement and (C) with respect to the Registration Statement
or any post-effective amendment, when the same has become effective, (ii) of any
request by the Commission or any other federal or state governmental authority
for amendments or supplements to the Registration Statement or Prospectus or for
additional information, (iii) of the issuance by the Commission of any stop
order suspending the effectiveness of the Registration Statement covering any or
all of the Registrable Securities or the initiation of any Proceedings for that
purpose, (iv) any of the representations and warranties of the Company contained
in any agreement (including any underwriting agreement) contemplated hereby
ceases to be true and correct in all material respects, (v) of the receipt by
the Company of any notification with respect to the suspension of the
qualification or exemption from qualification of any of the Registrable
Securities for sale in any jurisdiction, or the initiation or threatening of any
Proceeding for such purpose, (vi) of the occurrence of any event that makes any
statement made in the Registration Statement or Prospectus or any document
incorporated or deemed to be incorporated therein by reference untrue in any
material respect or that requires any revisions to the Registration Statement,
Prospectus or other documents so that, in the case of the Registration Statement
or the Prospectus, as the case may be, it will not contain any untrue statement
of a material fact or omit to state any material fact required to be stated
therein or necessary to make the statements
<PAGE>

therein, in light of the circumstances under which they were made, not
misleading and (vii) the beginning and end of a black-out period pursuant to
Section 3(r).

          (d)  Confirmation of Effectiveness. Within two (2) Business Days after
               -----------------------------
a Registration Statement which covers applicable Registrable Securities is
ordered effective by the Commission, the Company shall deliver, and shall cause
legal counsel for the Company to deliver, to the transfer agent for such
Registrable Securities (with copies to the Holders whose Registrable Securities
are included in such Registration Statement) confirmation that such Registration
Statement has been declared effective by the Commission in the form attached
hereto as Exhibit B.
          ---------

          (e)  Supplements and Post-Effective Amendments. If requested by the
               -----------------------------------------
Holders of a majority in interest of the Registrable Securities to be sold, (i)
promptly incorporate in a Prospectus supplement or post-effective amendment to
the Registration Statement such information as the Company reasonably agrees
should be included therein and (ii) make all required filings of such Prospectus
supplement or such post-effective amendment as soon as practicable after the
Company has received notification of the matters to be incorporated in such
Prospectus supplement or post-effective amendment; provided, however, that the
                                                   --------  -------
Company shall not be required to take any action pursuant to this Section 3(e)
that would, in the written opinion of counsel for the Company (addressed to the
Holder's Special Counsel), violate applicable law.

          (f)  Copies of Registration Statement.  Furnish to each Holder and
               --------------------------------
their Special Counsel, without charge, at least one conformed copy of each
Registration Statement and each amendment thereto, including financial
statements and schedules, all documents incorporated or deemed to be
incorporated therein by reference, and all exhibits to the extent requested by
such Person (including those previously furnished or incorporated by reference)
promptly after the filing of such documents with the Commission.

          (g)  Copies of Prospectus.  Promptly deliver to each Holder and their
               --------------------
Special Counsel without charge, as many copies of the Prospectus or Prospectuses
(including each form of prospectus) and each amendment or supplement thereto as
such Persons may reasonably request; and the Company hereby consents to the use
of such Prospectus and each amendment or supplement thereto by each of the
selling Holders in connection with the offering and sale of the Registrable
Securities covered by such Prospectus and any amendment or supplement thereto.

          (h)  Blue Sky.  Prior to any public offering of Registrable
               --------
Securities, use its best efforts to register or qualify or cooperate with the
selling Holders and their Special Counsel in connection with the registration or
qualification (or exemption from such registration or qualification) of such
Registrable Securities for offer and sale under the securities or Blue Sky laws
of such jurisdictions within the United States as any Holder requests in
writing, to keep each such registration or qualification (or exemption
therefrom) effective during the Effectiveness Period and to do any and all other
acts or things necessary or advisable to enable the disposition in such
jurisdictions of the Registrable Securities covered by a Registration Statement;
provided, however, that the Company shall not be required to qualify generally
--------  -------
to do business in any jurisdiction where it is not then so qualified or to take
any action that would subject it to general service of process in any such
jurisdiction where it is not then so subject or subject the Company to any
material tax in any such jurisdiction where it is not then so subject.
<PAGE>

          (i)  Certificates.  Cooperate with the Holders to facilitate the
               ------------
timely preparation and delivery of certificates representing Registrable
Securities to be sold pursuant to a Registration Statement, which certificates
shall be free, to the extent permitted by applicable law and the Purchase
Agreement, of all restrictive legends, and to enable such Registrable Securities
to be in such denominations and registered in such names as any such managing
underwriters or Holders may request at least two (2) Business Days prior to any
sale of Registrable Securities.

          (j)  Certain Revisions.  Upon the occurrence of any event contemplated
               -----------------
by Section 3(c)(vi), as promptly as possible, prepare a supplement or amendment,
including a post-effective amendment, to the Registration Statement or a
supplement to the related Prospectus or any document incorporated or deemed to
be incorporated therein by reference, and file any other required document so
that, as thereafter delivered, neither the Registration Statement nor such
Prospectus will contain an untrue statement of a material fact or omit to state
a material fact required to be stated therein or necessary to make the
statements therein, in light of the circumstances under which they were made,
not misleading.

          (k)  Listing.  Cause all Registrable Securities relating to such
               -------
Registration Statement to be listed on a National Market on which similar
securities issued by the Company are then listed or quoted as and when required
pursuant to the Purchase Agreement.

          (l)  Due Diligence.  Make available for inspection by the selling
               -------------
Holders, any representative of such Holders, and any attorney or accountant
retained by such selling Holders, at the offices where normally kept, during
reasonable business hours, all financial and other records, pertinent corporate
documents and properties of the Company and its subsidiaries, and cause the
officers, directors, agents and employees of the Company and its subsidiaries to
supply all information in each case reasonably requested by any such Holder,
representative, attorney or accountant in connection with the Registration
Statement; provided, however, that if any information is determined in good
           --------  -------
faith by the Company (in writing) to be of a confidential nature at the time of
delivery of such information, then prior to delivery of such information, the
Company and the Holders shall enter into a confidentiality agreement reasonably
acceptable to the Company and the Holders providing that such information shall
be kept confidential, unless (i) disclosure of such information is required by
court or administrative order or is necessary to respond to inquiries of
regulatory authorities (provided, however, that the Company shall be given
                        --------  -------
notice of any such pending disclosure so that the Company may seek a protective
order), (ii) disclosure of such information, in the opinion of counsel to such
Person, is required by law, (iii) such information becomes generally available
to the public other than as a result of a disclosure or failure to safeguard by
such Person, or (iv) such information becomes available to such Person from a
source other than the Company and such source is not bound by a confidentiality
agreement with the Company.

          (n)  Intentionally omitted.
<PAGE>

          (o)  Information.  The Company may require each selling Holder to
               -----------
furnish to the Company information regarding such Holder and the distribution of
such Registrable Securities as is required by law to be disclosed in the
Registration Statement, and the Company may exclude from such registration the
Registrable Securities of any such Holder who unreasonably fails to furnish such
information within a reasonable time after receiving such request.

          The Company shall hold in confidence and not make any disclosure of
information concerning a Holder provided to the Company unless (i) disclosure of
such information is necessary to comply with federal or state securities laws,
(ii) the disclosure of such information is necessary to avoid or correct a
misstatement or omission in any Registration Statement, (iii) the release of
such information is ordered pursuant to a subpoena or other order from a court
or governmental body of competent jurisdiction, or (iv) such information has
been made generally available to the public other than by disclosure in
violation of this Agreement or any other agreement.  The Company agrees that it
shall, upon learning that disclosure of such information concerning a Holder is
sought in or by a court or governmental body of competent jurisdiction or
through other means, give prompt notice to such Holder prior to making such
disclosure, and allow the Holder, at its expense, to undertake appropriate
action to prevent disclosure of, or to obtain a protective order for, such
information.

          If the Registration Statement refers to any Holder by name or
otherwise as the holder of any securities of the Company, then such Holder shall
have the right to require (if such reference to such Holder by name or otherwise
is not required by the Securities Act or any similar federal statute then in
force) the deletion of the reference to such Holder in any amendment or
supplement to the Registration Statement filed or prepared subsequent to the
time that such reference ceases to be required.

          Each Holder agrees by its acquisition of such Registrable Securities
that, upon receipt of a notice from the Company of the occurrence of any event
of the kind described in Section 3(c)(ii), 3(c)(iii), 3(c)(iv), 3(c)(v),
3(c)(vi) or 3(c)(vii), such Holder will forthwith discontinue disposition of
such Registrable Securities under the Registration Statement until such Holder's
receipt of the copies of the supplemented Prospectus and/or amended Registration
Statement contemplated by Section 3(j), or until it is advised in writing (the
"Advice") by the Company that the use of the applicable Prospectus may be
 ------
resumed, and, in either case, has received copies of any additional or
supplemental filings that are incorporated or deemed to be incorporated by
reference in such Prospectus or Registration Statement.

          (p)  Responses to the Commission.  The Company agrees to respond fully
               ---------------------------
and completely to any and all comments on a Registration Statement received from
the Commission staff as promptly as possible but, in no event later than ten
(10) Business Days of the receipt of such comments, regardless of whether such
comments are in oral or written form.

          (q)  Suspensions.  Use its best efforts to avoid the issuance of, or,
               -----------
if issued, obtain the withdrawal of (i) any order suspending the effectiveness
of the Registration Statement or (ii) any suspension of the qualification (or
exemption from qualification) of any of the Registrable Securities for sale in
any jurisdiction, at the earliest practicable moment.
<PAGE>

          (r)  Black-out Periods.  Subject to the last sentence of this Section
               -----------------
3(r), the Company may by written notice require that the Holders immediately
cease sales of Registrable Securities (for a period not to exceed twenty (20)
consecutive days in any one instance and for a period not to exceed fifty (50)
calendar days in any twelve-month period) pursuant to a Registration Statement
at any time that (i) the Company becomes engaged in a business activity or
negotiation which is not disclosed in a Registration Statement (or the
prospectus included therein) which the Company reasonably believes must be
disclosed therein under applicable law and which the Company desires to keep
confidential for business purposes, (ii) the Company determines that a
particular disclosure so determined to be required to be disclosed therein would
be premature or would adversely affect the Company or its business or prospects
or (iii) the Registration Statement can no longer be used under the existing
rules and regulations promulgated under the Securities Act (each of (i), (ii) or
(iii), a "Material Condition").  The Company shall not be required to disclose
          ------------------
to the Holders which of the reasons specified in (i), (ii) or (iii) above is the
basis for requiring a suspension of sales due to the occurrence of a Material
Condition.  The Company will use its commercially reasonable best efforts to
ensure that the use of the Registration Statement (and the prospectus included
therein) may be resumed as soon as it is practicable.  The Company may not
suspend sales of Registrable Securities under a Registration Statement pursuant
to this Section 3(r) more than four (4) times during any twelve-month period.

     4.   Registration Expenses.
          ---------------------

          All fees and expenses incident to the performance of or compliance
with this Agreement by the Company shall be borne by the Company, whether or not
the Registration Statement is filed or becomes effective and whether or not any
Registrable Securities are sold pursuant to the Registration Statement. The fees
and expenses referred to in the foregoing sentence shall include, without
limitation, (i) all registration and filing fees (including, without limitation,
fees and expenses (A) with respect to filings required to be made with the
National Market and each other securities exchange or market on which
Registrable Securities are required hereunder to be listed or quoted and (B) in
compliance with state securities or Blue Sky laws (including, without
limitation, fees and disbursements of counsel for the Holders in connection with
Blue Sky qualifications of the Registrable Securities and determination of the
eligibility of the Registrable Securities for investment under the laws of such
jurisdictions as the Holders of a majority of Registrable Securities may
designate)), (ii) printing expenses (including, without limitation, expenses of
printing certificates for Registrable Securities and of printing prospectuses if
the printing of prospectuses is requested by the Holders of a majority of the
Registrable Securities included in the Registration Statement), (iii) messenger,
telephone and delivery expenses, (iv) reasonable fees and disbursements of
counsel for the Company and Special Counsel for the Holders, up to an aggregate
$25,000 (the "Fee Cap"), (v) Securities Act liability insurance, if the Company
so desires such insurance, and (vi) fees and expenses of all other Persons
retained by the Company in connection with the consummation of the transactions
contemplated by this Agreement.  In addition, the Company shall be responsible
for all of its internal expenses incurred in connection with the consummation of
the transactions contemplated by this Agreement (including, without limitation,
all salaries and expenses of its officers and employees performing legal or
accounting duties), the expense of any annual audit, and the fees and expenses
incurred in connection with the listing of the Registrable Securities on
<PAGE>

any securities exchange, system or market as required hereunder. The Holders
shall pay the fees and expenses of the Special Counsel retained by them in
excess of the Fee Cap.

     5.   Indemnification.
          ---------------

          (a) Indemnification by the Company.  The Company shall,
              ------------------------------
notwithstanding any termination of this Agreement, indemnify and hold harmless
each Holder, the officers, directors, agents (including any underwriters
retained by such Holder in connection with the offer and sale of Registrable
Securities), brokers (including brokers who offer and sell Registrable
Securities as principal as a result of a pledge or any failure to perform under
a margin call of Common Stock), investment advisors and employees of each such
Holder, each Person who controls any such Holder (within the meaning of Section
15 of the Securities Act or Section 20 of the Exchange Act) and the officers,
directors, agents and employees of each such controlling Person, to the fullest
extent permitted by applicable law, from and against any and all joint or
several losses, claims, damages, liabilities, costs (including, without
limitation, costs of preparation and reasonable attorneys' fees) and expenses
(collectively, together with Proceedings by any regulatory or self-regulatory
organization, whether commenced or threatened, "Losses"), as incurred, arising
                                                ------
out of or relating to (i) any untrue or alleged untrue statement of a material
fact contained in the Registration Statement, any Prospectus or any form of
prospectus or in any amendment or supplement thereto or in any preliminary
Prospectus, or arising out of or relating to any omission or alleged omission of
a material fact required to be stated therein or necessary to make the
statements therein (in the case of any Prospectus or form of prospectus or
amendment or supplement thereto, in light of the circumstances under which they
were made) not misleading, except to the extent, but only to the extent, that
such untrue statements or omissions are based solely upon and in conformity with
information regarding such Holder furnished in writing to the Company by such
Holder expressly for use therein, which information was reasonably relied on by
the Company for use therein or to the extent that such information relates to
such Holder or such Holder's proposed method of distribution of Registrable
Securities and was reviewed and expressly approved in writing by such Holder
expressly for use in the Registration Statement, such Prospectus or such form of
prospectus or in any amendment or supplement thereto (provided that the Company
                                                      --------
amended any disclosure with respect to the method of distribution upon written
notice from the Holders that such section of the Prospectus should be revised in
any way) or (ii) any violation or alleged violation by the Company of the
Securities Act, the Exchange Act, any other law, including, without limitation,
any state securities law, or any rule or regulation thereunder relating to the
offer or sale of Registrable Securities.  The Company shall not, however, be
liable to any Holder for any Losses with respect to any untrue or alleged untrue
statement of material fact or omission or alleged omission of material fact if
such statement or omission was made in a preliminary Prospectus and such Holder
did not receive a copy of the final Prospectus (or any amendment or supplement
thereto) at or prior to the confirmation of the sale of the Registrable
Securities in any case where such delivery is required by the Securities Act and
the untrue or alleged untrue statement of material fact or omission or alleged
omission of material fact contained in such preliminary Prospectus was corrected
in the final Prospectus (or any amendment or supplement thereto), unless the
failure to deliver such final Prospectus (as amended or supplemented) was a
result of noncompliance by the Company with Section 3(g) of this Agreement.  The
Company shall notify
<PAGE>

the Holders promptly of the institution, threat or assertion of any Proceeding
of which the Company is aware in connection with the transactions contemplated
by this Agreement.

          (b) Indemnification by Holders.  Each Holder shall, severally and not
              --------------------------
jointly, indemnify and hold harmless the Company, its officers, directors,
agents and employees, each Person who controls the Company (within the meaning
of Section 15 of the Securities Act and Section 20 of the Exchange Act), and the
officers, directors, agents and employees of such controlling Persons, to the
fullest extent permitted by applicable law, from and against all Losses, as
incurred, arising solely out of or based solely upon any untrue statement of a
material fact contained in the Registration Statement, any Prospectus, or any
form of prospectus, or arising solely out of or based solely upon any omission
of a material fact required to be stated therein or necessary to make the
statements therein not misleading to the extent, but only to the extent, that
such untrue statement or omission is contained in any information so furnished
in writing by such Holder to the Company specifically for inclusion in the
Registration Statement or such Prospectus and that such information was
reasonably relied upon by the Company for use in the Registration Statement,
such Prospectus or such form of prospectus or to the extent that such
information relates to such Holder or such Holder's proposed method of
distribution of Registrable Securities and was reviewed and expressly approved
in writing by such Holder expressly for use in the Registration Statement, such
Prospectus or such form of prospectus; provided, however, that the indemnity
                                       --------  -------
agreement contained in this Section 5(b) shall not apply to amounts paid in
settlement of any Losses if such settlement is effected without the prior
written consent of such Holder, which consent shall not be unreasonably
withheld.  In no event shall the liability of any selling Holder hereunder be
greater in amount than the dollar amount of the gross proceeds received by such
Holder upon the sale of the Registrable Securities giving rise to such
indemnification obligation.

          (c) Conduct of Indemnification Proceedings.  If any Proceeding shall
              --------------------------------------
be brought or asserted against any Person entitled to indemnity hereunder (an
"Indemnified Party"), such Indemnified Party promptly shall notify the Person
------------------
from whom indemnity is sought (the "Indemnifying Party") in writing, and the
                                    ------------------
Indemnifying Party shall assume the defense thereof, including the employment of
counsel reasonably satisfactory to the Indemnified Party and the payment of all
reasonable fees and expenses incurred in connection with defense thereof;
provided, however, that the failure of any Indemnified Party to give such notice
--------- -------
shall not relieve the Indemnifying Party of its obligations or liabilities
pursuant to this Agreement, except (and only) to the extent that it shall be
finally determined by a court of competent jurisdiction (which determination is
not subject to appeal or further review) that such failure shall have
proximately and materially adversely prejudiced the Indemnifying Party.

          An Indemnified Party shall have the right to employ separate counsel
in any such Proceeding and to participate in the defense thereof, but the fees
and expenses of such counsel shall be at the expense of such Indemnified Party
or Indemnified Parties unless: (i) the Indemnifying Party has agreed in writing
to pay such fees and expenses; (ii) the Indemnifying Party shall have failed
promptly to assume the defense of such Proceeding and to employ counsel
reasonably satisfactory to such Indemnified Party in any such Proceeding; or
(iii) the named parties to any such Proceeding (including any impleaded parties)
include both such Indemnified Party and the Indemnifying Party, and such
Indemnified Party shall have been
<PAGE>

advised by counsel that a conflict of interest is likely to exist if the same
counsel were to represent such Indemnified Party and the Indemnifying Party (in
which case, if such Indemnified Party notifies the Indemnifying Party in writing
that it elects to employ separate counsel at the expense of the Indemnifying
Party, the Indemnifying Party shall not have the right to assume the defense
thereof and such counsel shall be at the reasonable expense of the Indemnifying
Party). The Indemnifying Party shall not be liable for any settlement of any
such Proceeding effected without its written consent, which consent shall not be
unreasonably withheld. No Indemnifying Party shall, without the prior written
consent of the Indemnified Party, effect any settlement of any pending
Proceeding in respect of which any Indemnified Party is a party, unless such
settlement includes an unconditional release of such Indemnified Party from all
liability on claims that are the subject matter of such Proceeding.

          All reasonable fees and expenses of the Indemnified Party (including
fees and expenses to the extent incurred in connection with investigating or
preparing to defend such Proceeding in a manner not inconsistent with this
Section) shall be paid to the Indemnified Party, as incurred, within ten (10)
Business Days of written notice thereof to the Indemnifying Party, which notice
shall be delivered no more frequently than on a monthly basis (regardless of
whether it is ultimately determined that an Indemnified Party is not entitled to
indemnification hereunder; provided, that the Indemnifying Party may require
                           --------
such Indemnified Party to undertake to reimburse all such fees and expenses to
the extent it is finally judicially determined that such Indemnified Party is
not entitled to indemnification hereunder).

          (d) Contribution.  If a claim for indemnification under Section 5(a)
              ------------
or 5(b) is unavailable to an Indemnified Party because of a failure or refusal
of a court of competent jurisdiction to enforce such indemnification in
accordance with its terms (by reason of public policy or otherwise), then each
Indemnifying Party, in lieu of indemnifying such Indemnified Party, shall
contribute to the amount paid or payable by such Indemnified Party as a result
of such Losses, in such proportion as is appropriate to reflect the relative
fault of the Indemnifying Party and Indemnified Party in connection with the
actions, statements or omissions that resulted in such Losses as well as any
other relevant equitable considerations.  The relative fault of such
Indemnifying Party and Indemnified Party shall be determined by reference to,
among other things, whether any action in question, including any untrue or
alleged untrue statement of a material fact or omission or alleged omission of a
material fact, has been taken or made by, or relates to information supplied by,
such Indemnifying Party or Indemnified Party, and the parties' relative intent,
knowledge, access to information and opportunity to correct or prevent such
action, statement or omission.  The amount paid or payable by a party as a
result of any Losses shall be deemed to include, subject to the limitations set
forth in Section 5(c), any reasonable attorneys' or other reasonable fees or
expenses incurred by such party in connection with any Proceeding to the extent
such party would have been indemnified for such fees or expenses if the
indemnification provided for in this Section was available to such party in
accordance with its terms.   In no event shall any selling Holder be required to
contribute an amount under this Section 5(d) in excess of the gross proceeds
received by such Holder upon sale of the Registrable Securities pursuant to the
Registration Statement giving rise to such contribution obligation.
<PAGE>

          The parties hereto agree that it would not be just and equitable if
contribution pursuant to this Section 5(d) were determined by pro rata
allocation or by any other method of allocation that does not take into account
the equitable considerations referred to in the immediately preceding paragraph.
No Person guilty of fraudulent misrepresentation (within the meaning of Section
11(f) of the Securities Act) shall be entitled to contribution from any Person
who was not guilty of such fraudulent misrepresentation.

          The indemnity and contribution agreements contained in this Section
are in addition to any liability that the Indemnifying Parties may have to the
Indemnified Parties.

     6.   Miscellaneous.
          -------------

          (a) Remedies.   In the event of a breach by the Company or by a Holder
              --------
of any of their obligations under this Agreement, each Holder or the Company, as
the case may be, in addition to being entitled to exercise all rights granted by
law and under this Agreement, including recovery of damages, will be entitled to
specific performance of its rights under this Agreement.  The Company and each
Holder agree that monetary damages would not provide adequate compensation for
any losses incurred by reason of a breach by it of any of the provisions of this
Agreement and hereby further agrees that, in the event of any action for
specific performance in respect of such breach, it shall waive the defense that
a remedy at law would be adequate.

          (b) No Inconsistent Agreements.  Neither the Company nor any of its
              --------------------------
subsidiaries has, as of the date hereof, nor shall the Company or any of its
subsidiaries, on or after the date of this Agreement, enter into any agreement
with respect to its securities that is inconsistent with the rights granted to
the Holders in this Agreement or otherwise conflicts with the provisions hereof.
This Agreement, together with the Purchase Agreement, contain the entire
understanding of the parties with respect to the subject matter hereof and
supersede all prior agreements and understandings, oral or written, with respect
to such matters.

          (c) Amendments and Waivers.  The provisions of this Agreement,
              ----------------------
including the provisions of this sentence, may not be amended, modified or
supplemented, and waivers or consents to departures from the provisions hereof
may not be given, unless the same shall be in writing and signed by the Company
and the Majority Holders; provided, however, that for the purposes of this
                          --------  -------
sentence, Registrable Securities that are owned, directly or indirectly, by the
Company, or an Affiliate of the Company are not deemed outstanding.
Notwithstanding the foregoing, a waiver or consent to depart from the provisions
hereof with respect to a matter that relates exclusively to the rights of a
Holder and that does not directly or indirectly affect the rights of any other
Holders may be given by the Holders to which such waiver or consent relates;
provided, however, that the provisions of this sentence may not be amended,
--------  -------
modified, or supplemented except in accordance with the provisions of the
immediately preceding sentence.  Any amendment or waiver effected in accordance
with this Section shall be binding upon each Holder, each future Holder, and the
Company.  Upon effectiveness of each such amendment or waiver, the Company shall
promptly give written notice thereof to the Holders who have not previously
consented thereto in writing.
<PAGE>

          (d) Notices.  Any notices, consents, waivers or other communications
              -------
required or permitted to be given under the terms of this Agreement must be in
writing and will be deemed to have been delivered (i) upon receipt, when
delivered personally, (ii) upon receipt, when sent by facsimile, provided
                                                                 --------
confirmation of transmission is mechanically or electronically generated and
kept on file by the sending party (if received by or before 5:00 p.m. Eastern
Time where such notice is received) or the first (1st) Business Day following
such delivery (if received after 5:00 p.m. Eastern Time where such notice is
received) or (iii) one (1) Business Day after deposit with a nationally
recognized overnight courier.  The addresses for such communications are (A) if
to the Company, to the address set forth on Schedule I hereto, with copies to
                                            ----------
Morgan, Lewis & Bockius, LLP, 1701 Market Street, Philadelphia, PA  19103,
Attention: Christine J. Arasin, Esq., facsimile no. (215) 963-5299, (B) if to
any Purchaser, to its address set forth on Schedule I hereto, with copies to
                                           ----------
Akin, Gump, Strauss, Hauer & Feld, L.L.P., 590 Madison Avenue, New York, New
York 10022, Attention: James E. Kaye, Esq., facsimile no. (212) 872-1002, or to
such other address as may be designated in writing hereafter, in the same
manner, by such Person, and (C) if to any Placement Agent, to its address set
forth on Schedule I hereto, with copies to Pepper Hamilton LLP, 3000 Two Logan
         ----------
Square, Philadelphia, PA  19103, Attention:  Russell Paul, Esq., facsimile no.
(215) 981-4750.

          (e) Successors and Assigns.  This Agreement shall inure to the benefit
              ----------------------
of and be binding upon the successors and permitted assigns of each of the
parties and shall inure to the benefit of each Holder.  The Company may not
assign its rights or obligations hereunder without the prior written consent of
the Majority Holders.  Each Holder may assign its rights hereunder in the manner
and to the Persons as permitted under the Purchase Agreement.  In addition, the
rights of each Holder hereunder, including the right to have the Company
register for resale Registrable Securities in accordance with the terms of this
Agreement, shall be automatically assignable by each Holder if: (i) the Holder
agrees in writing with the transferee or assignee to assign such rights, and a
copy of such agreement is furnished to the Company within a reasonable time
after such assignment; (ii) the Company is, within a reasonable time after such
transfer or assignment, furnished with written notice of (A) the name and
address of such transferee or assignee and (B) the securities with respect to
which such registration rights are being transferred or assigned; (iii)
following such transfer or assignment the further disposition of such securities
by the transferee or assignees is restricted under the Securities Act and
applicable state securities laws; (iv) at or before the time the Company
receives the written notice contemplated by clause (ii) of this Section, the
transferee or assignee agrees in writing with the Company to be bound by all of
the provisions of this Agreement; and (v) such transfer shall have been made in
accordance with the applicable requirements of the Purchase Agreement.

          (f) Counterparts.  This Agreement may be executed in any number of
              ------------
counterparts, each of which when so executed shall be deemed to be an original
and all of which taken together shall constitute one and the same Agreement.  In
the event that any signature is delivered by facsimile transmission, such
signature shall create a valid and binding obligation of the party executing (or
on whose behalf such signature is executed) the same with the same force and
effect as if such facsimile signature were the original thereof.
<PAGE>

          (i) Governing Law.  The corporate laws of the State of New York shall
              -------------
govern all issues concerning the relative rights of the Company and the Holders
as its stockholders.  All other questions concerning the construction, validity,
enforcement and interpretation of  this Agreement shall be governed by and
construed in accordance with the laws of the State of New York, without regard
to principles of conflicts of law.  Each party hereby irrevocably submits to the
exclusive jurisdiction of the state and federal courts sitting in the City of
New York, Borough of Manhattan, for the adjudication of any dispute hereunder or
in connection herewith or with any transaction contemplated hereby or discussed
herein, and hereby irrevocably waives, and agrees not to assert in any
Proceeding any claim that it is not personally subject to the jurisdiction of
any such court, that such Proceeding is improper.  Nothing contained herein
shall be deemed to limit in any way any right to serve process in any manner
permitted by law.

          (j) Cumulative Remedies.  The remedies provided herein are cumulative
              -------------------
and not exclusive of any remedies provided by law.

          (k) Severability.  If any term, provision, covenant or restriction of
              ------------
this Agreement is held by a court of competent jurisdiction to be invalid,
illegal, void or unenforceable, the remainder of the terms, provisions,
covenants and restrictions set forth herein shall remain in full force and
effect and shall in no way be affected, impaired or invalidated, and the parties
hereto shall use their reasonable efforts to find and employ an alternative
means to achieve the same or substantially the same result as that contemplated
by such term, provision, covenant or restriction.  It is hereby stipulated and
declared to be the intention of the parties that they would have executed the
remaining terms, provisions, covenants and restrictions without including any of
such that may be hereafter declared invalid, illegal, void or unenforceable.

          (l) Headings.  The headings in this Agreement are for convenience of
              --------
reference only and shall not limit or otherwise affect the meaning hereof.

          (m) Shares Held by The Company and its Affiliates.  Whenever the
              ---------------------------------------------
consent or approval of Holders of a specified percentage of Registrable
Securities is required hereunder, Registrable Securities held by the Company or
its Affiliates (other than any Holder or transferees or successors or assigns
thereof if such Holder is deemed to be an Affiliate solely by reason of its
holdings of such Registrable Securities) shall not be counted in determining
whether such consent or approval was given by the Holders of such required
percentage.

                           [SIGNATURE PAGES FOLLOW]
<PAGE>

          IN WITNESS WHEREOF, the parties have executed this Registration Rights
Agreement as of the date first written above.

                         ORTHOVITA, INC.

                         By:  /s/ Bruce Peacock
                             ----------------------------------
                             Name:  Bruce Peacock
                             Title: Executive Officer

                         BROWN SIMPSON PARTNERS I, LTD.

                         By:  Brown Simpson Partners I, Ltd.

                         By: /s/ Peter D. Greene
                            -----------------------------------
                            Name:  Peter D. Greene
                            Title: Attorney-in-Fact

                         JANNEY MONTGOMERY SCOTT LLC.

                         By: /s/ Anthony Lopez-Ona
                            -----------------------------------
                            Name:  Anthony Lopez-Ona
                            Title: Vice President

                         EMERGING GROWTH EQUITIES, LTD.

                         By: /s/ Gregory J. Berlacher
                            -----------------------------------
                            Name:  Gregory J. Berlacher
                            Title: Chief Executive Officer

                         VFT SPECIAL VENTURES LTD.

                         By: /s/ Gregory J. Berlacher
                            -----------------------------------
                            Name:  Gregory J. Berlacher
                            Title: Chief Executive Officer
<PAGE>

                                  SCHEDULE I
                                  ----------

Company
-------

Orthovita, Inc.
45 Great Valley Parkway
Malvern, PA 19355
Attention:  Joseph Paiva, CFO
Facsimile:  (610) 640-2603

Purchasers:
----------

Brown Simpson Partners I, Ltd
152 West 57/th/ Street, 40/th/ Floor
New York, New York 10019
Attention:  Peter D. Greene, Managing Principal,
            Chief Operating Officer and General Counsel
Facsimile:  (212) 247-1329

Placement Agents:

Janney Montgomery Scott LLC
1801 Market Street
Philadelphia, PA  19103
Attention:  Anthony Lopez-Ona
Facsimile:  (215) 665-6254

Emerging Growth Equities, Ltd.
Parkview Tower
1150 First Avenue, Suite 600
King of Prussia, PA  19406
Attention:  Gregory Berlacher
Facsimile:  (610) 783-4761

Designee of Emerging Growth Equities, Ltd.:
VFT Special Ventures Ltd.
Parkview Tower
1150 First Avenue, Suite 600
King of Prussia, PA  19406
Attention:  Gregory Berlacher
Facsimile:  (610) 783-4761

                                      18
<PAGE>

                                                                       EXHIBIT A

                             PLAN OF DISTRIBUTION

          Our company is registering the shares of common stock on behalf of the
selling stockholders.  All costs, expenses and fees in connection with the
registration of the shares offered by this prospectus will be borne by our
company, other than brokerage commissions and similar selling expenses, if any,
attributable to the sale of shares which will be borne by the selling
stockholders.  Sales of shares may be effected by selling stockholders from time
to time in one or more types of transactions (which may include block
transactions) on _______, in the over-the-counter market, in negotiated
transactions, through put or call options transactions relating to the shares,
through short sales of shares, or a combination of such methods of sale, at
market prices prevailing at the time of sale, or at negotiated prices.  Such
transactions may or may not involve brokers or dealers.  The selling
stockholders have advised our company that they have not entered into any
agreements, understandings or arrangements with any underwriters or broker-
dealers regarding the sale of their securities, nor is there an underwriter or
coordinated broker acting in connection with the proposed sale of shares by the
selling stockholders.

          The selling stockholders may enter into hedging transactions with
broker-dealers or other financial institutions.  In connection with such
transactions, broker-dealers or other financial institutions may engage in short
sales of the shares or of securities convertible into or exchangeable for the
shares in the course of hedging positions they assume with selling stockholders.
The selling stockholders may also enter into options or other transactions with
broker-dealers or other financial institutions which require the delivery to
such broker-dealers or other financial institutions of shares offered by this
prospectus, which shares such broker-dealer or other financial institution may
resell pursuant to this prospectus (as amended or supplemented to reflect such
transaction).

          The selling stockholders may make these transactions by selling shares
directly to purchasers or to or through broker-dealers, which may act as agents
or principals.  Such broker-dealers may receive compensation in the form of
discounts, concessions or commissions from selling stockholders and/or the
purchasers of shares for whom such broker-dealers may act as agents or to whom
they sell as principal, or both (which compensation as to a particular broker-
dealer might be in excess of customary commissions).

          The selling stockholders and any broker-dealers that act in connection
with the sale of shares are "underwriters" within the meaning of Section 2(11)
of the Securities Act, and any commissions received by such broker-dealers or
any profit on the resale of the shares sold by them while acting as principals
might be deemed to be underwriting discounts or commissions under the Securities
Act.  The selling stockholders may agree to indemnify any agent, dealer or
broker-dealer that participates in transactions involving sales of the shares
against certain liabilities, including liabilities arising under the Securities
Act.
<PAGE>

          Because selling stockholders are "underwriters" within the meaning of
Section 2(11) of the Securities Act, the selling stockholders will be subject to
the prospectus delivery requirements of the Securities Act. Our company has
informed the selling stockholders that the anti-manipulative provisions of
Regulation M promulgated under the Exchange Act may apply to their sales in the
market.

          Selling stockholders also may resell all or a portion of the shares in
open market transactions in reliance upon Rule 144 under the Securities Act,
provided they meet the criteria and conform to the requirements of Rule 144.

          Upon our company being notified by a selling stockholder that any
material arrangement has been entered into with a broker-dealer for the sale of
shares through a block trade, special offering, exchange distribution or
secondary distribution or a purchase by a broker or dealer, a supplement to this
prospectus will be filed, if required, pursuant to Rule 424(b) under the
Securities Act, disclosing:

          . the name of each such selling stockholder and of the participating
            broker-dealer(s);

          . the number of shares involved;

          . the initial price at which such shares were sold;

          . the commissions paid or discounts or concessions allowed to such
            broker-dealer(s), where applicable;

          . that such broker-dealer(s) did not conduct any investigation to
            verify the information set out or incorporated by reference in this
            prospectus; and

          . other facts material to the transactions.

In addition, upon our company being notified by a selling stockholder that a
donee or pledgee intends to sell more than 500 shares, a supplement to this
prospectus will be filed.

                                       2
<PAGE>

                                                                       EXHIBIT B

                        FORM OF NOTICE OF EFFECTIVENESS
                           OF REGISTRATION STATEMENT

[TRANSFER AGENT]
Attention:

            Re:  Orthovita, Inc.

Ladies and Gentlemen:

     We are counsel to Orthovita, Inc., a Pennsylvania corporation (the
"Company"), and have represented the Company in connection with: (i) that
certain Subscription Agreement (the "Purchase Agreement") entered into by and
among the Company and the purchaser named therein (the "Purchaser") pursuant to
which the Company issued to the Holders shares of the Company's common stock,
par value $0.01 per share, purchase rights to purchase the Company's common
stock in certain events, and warrants to purchase the Company's common stock
(the "Warrants"); and (ii) that certain Placement Agents Agreement (the
"Placement Agents Agreement") entered into by and among the Company and the
placement agents named therein (collectively with the Purchaser, the "Holders").
Pursuant to the Purchase Agreement and the Placement Agents Agreement, the
Company also has entered into a Registration Rights Agreement with the Holders
(the "Registration Rights Agreement") pursuant to which the Company agreed,
among other things, to register the Registrable Securities (as defined in the
Registration Rights Agreement), including the shares of Common Stock issuable
upon exercise of the Warrants and warrants to purchase the Company's common
stock issued to the Placement Agents, under the Securities Act of 1933, as
amended (the "1933 Act"). In connection with the Company's obligations under the
Registration Rights Agreement, on _______________, 2000, the Company filed a
Registration Statement on Form [S-3/S-1] (File No. 333-_____________) (the
"Registration Statement") with the Securities and Exchange Commission (the
"SEC") relating to the Registrable Securities which names each of the Holders as
a selling stockholder thereunder.

     In connection with the foregoing, we advise you that a member of the SEC's
staff has advised us by telephone that the SEC has entered an order declaring
the Registration Statement effective under the 1933 Act at [ENTER TIME OF
EFFECTIVENESS] on [ENTER DATE OF EFFECTIVENESS] and we have no knowledge, after
telephonic inquiry of a member of the SEC's staff, that any stop order
suspending its effectiveness has been issued or that any proceedings for that
purpose are pending before, or threatened by, the SEC and the Registrable
Securities are available for resale under the 1933 Act pursuant to the
Registration Statement.

                                             Very truly yours,

                                             [ISSUER'S COUNSEL]

cc:  [LIST NAMES OF HOLDERS]

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