Document:

Exhibit 10.3

 

EMPLOYMENT AGREEMENT

 

THIS EMPLOYMENT
AGREEMENT (this “Agreement”) is dated as of June 5, 2015 and is entered into by and between Bradford
C. Barton (the “Executive”) and Alliqua BioMedical, Inc. (the “Company”). The
Company and the Executive shall be referred to herein as the “Parties.”

 

RECITALS

 

Whereas,
the Company desires to employ the Executive as its Chief Operating Officer and the Executive desires to be employed by the Company
as its Chief Operating Officer;

 

Whereas,
the Company and the Executive desire to set forth in writing the terms and conditions of their agreement and understandings with
respect to the employment of the Executive as its Chief Operating Officer; and

 

Whereas,
the Company hereby employs the Executive, and the Executive hereby accepts employment with the Company for the period and upon
the terms and conditions contained in this Agreement.

 

Now,
Therefore, in consideration of the mutual promises and agreements contained herein, and other good and valuable consideration,
the receipt and sufficiency of which are hereby acknowledged, and intending to be legally bound, the Parties hereby agree as follows:

 

ARTICLE I.

Services
to be Provided by Executive

 

A.           Position
and Responsibilities. The Executive shall serve in the position of Chief Operating Officer, and shall perform services
for the Company as requested or as needed to perform the Executive’s job. The duties of the Executive shall be those duties
which can reasonably be expected to be performed by a person in such position.

 

B.           Performance.
During the Executive’s employment with the Company, the Executive shall devote on a full-time basis all of the Executive’s
time, energy, skill and reasonable best efforts to the performance of the Executive’s duties hereunder in a manner that will
faithfully and diligently further the business and interests of the Company, and shall exercise reasonable best efforts to perform
the Executive’s duties in a diligent, trustworthy, good faith and business-like manner, all for the purpose of advancing
the business of the Company. The Executive shall at all times act in a manner consistent with Executive’s position.

 

    	 

    	 

    

 

ARTICLE II.

Compensation
for SErvices

 

As compensation for
all services the Executive will perform under this Agreement, the Company will pay the Executive, and the Executive shall accept
as full compensation, the following:

 

A.           Base
Salary. The Company shall pay the Executive a monthly salary of twenty thousand dollars ($20,000.00)
($ 240,000.00 annualized), less applicable payroll deductions and tax withholdings (the “Base Salary”)
for all services rendered by the Executive under this Agreement. The Company shall pay the Base Salary in accordance with the normal
payroll policies of the Company.

 

B.           Performance
Bonus. The Executive shall be entitled to receive annual bonuses (“Performance Bonuses”) in an amount
equal to 60% of the Executive’s Base Salary for each calendar year during employment based on the extent to which
performance criteria for the year have been met which shall be paid on or before March 15th of the calendar year after the calendar
year to which the Performance Bonus relates to. Except as otherwise provided in Article III.B.(ii) of this Agreement, be eligible
to receive a Performance Bonus for a calendar year, the Executive must remain employed through the end of the applicable calendar
year. All performance criteria shall be established reasonably and in good faith by the Board of Directors (the “Board”).
The evaluation of the Company’s performance, as measured by the applicable performance criteria and the awarding of bonuses,
if any, shall be determined reasonably and in good faith by the Board.

 

C.           Stock.
The Executive has received, and may be eligible to receive, certain grants of stock options to purchase shares of common stock
of the Company, awards for Restricted Stock Units, and grants of Restricted Stock Awards, set forth separately in those certain
agreements.

 

D.           Expenses.
The Company agrees that, during the Executive's employment, it will reimburse the Executive for out-of-pocket expenses reasonably
incurred in connection with the Executive's performance of the Executive’s services hereunder, upon the presentation by the
Executive of an itemized accounting of such expenditures, with supporting receipts, provided that the Executive submits such expenses
for reimbursement within thirty (30) days of the date such expenses were incurred. Reimbursement shall be in compliance with the
Company’s expense reimbursement policies.

 

E.           Vacation.
The Executive also shall be eligible for four (4) weeks paid vacation in accordance with the Company’s policy, as in effect
from time to time.

 

F.           Car
Allowance. During the Executive’s employment, the Company shall provide to the Executive a $700.00 per month car
allowance.

 

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G.           Other
Benefits. The Executive is entitled to participate in any group health insurance plan, option or similar incentive compensation
plan, 401(k) plan, disability plan, group life plan, and any other benefit or welfare program or policy that is made generally
available, from time to time, to other employees of the Company, on a basis consistent with such participation and subject to the
terms of the plan documents, as such plans may be modified, amended, terminated, or replaced from time to time.

 

ARTICLE III.

Term; Termination

 

A.           Term
of Employment. The term of the Executive’s employment under this Agreement shall continue in effect until terminated
by either party.

 

B.           Termination.
Either party may terminate the Executive’s employment at any time upon written notice. The date of the Executive’s
termination shall be the date stated in the notice of termination. Upon termination of the Executive’s employment, the Company
shall pay the Executive (i) any unpaid Base Salary accrued through the date of termination, (ii) any unpaid Performance Bonus earned
and accrued for a previously completed calendar year, (iii) any accrued and unpaid vacation or similar pay to which the Executive
is entitled as a matter of law or Company policy, and (iv) any unreimbursed expenses properly
incurred prior to the date of termination (the “Accrued Obligations”). The Executive’s termination
under this Agreement shall also constitute the Executive’s resignation as an officer or director of any affiliate or subsidiary
of the Company, as applicable.

 

(i)          Termination
for Cause or Voluntary Resignation. In the event the Company terminates the Executive’s employment for Cause (defined
below) or the Executive voluntarily resigns without Good Reason (defined below), the Company shall have no further liability or
obligation to the Executive under this Agreement or in connection with the Executive’s employment hereunder, except for the
Accrued Obligations. The Accrued Obligations shall be payable in a lump sum within the time period required by applicable law,
and in no event later than thirty (30) days following termination of employment. For purposes of this Agreement, “Cause”
means termination because of: (a) an act or acts of theft, embezzlement, fraud, or willful or material misrepresentation by the
Executive; (b) the Executive’s indictment or conviction of, or pleading nolo contendere or guilty to, a felony, or a crime
involving moral turpitude; (c) the Executive’s refusal to perform, or intentional disregard of, in any material respect,
the Executive’s duties and responsibilities hereunder; and (d) a material breach by the Executive of this Agreement or any
other agreement to which the Executive and the Company are parties. In each such event listed above, if the circumstances are curable,
the Company shall give the Executive written notice thereof which shall specify in reasonable detail the circumstances constituting
Cause, and there shall be no Cause with respect to any such circumstances if cured by the Executive within thirty (30) days after
such notice.

 

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(ii)         Termination
Without Cause or for Good Reason. In the event the Executive’s employment is terminated by the Company without Cause
or by the Executive for Good Reason, the Executive shall receive the following, subject to the execution and timely return by the
Executive of a release of claims in the form to be delivered by the Company, which release shall, by its terms, be irrevocable
no later than the sixtieth (60th) day following the termination of employment: (a) the Accrued Obligations, payable
in a lump sum within the time period required by applicable law, and in no event later than thirty (30) days following termination
of employment; (b) if the Executive was employed by the Company through at least July 1st of the applicable calendar year, a pro-rata
portion of any Performance Bonus earned during such calendar year, with the amount prorated based on the number of days employed
during such calendar year and payable in a lump sum within the time period required by applicable law, but in no event later than
March 15th of the calendar year after the calendar year to which the Performance Bonus relates; (c) severance pay in an amount
equal to the Executive’s Base Salary for twelve (12) months (the “Severance Period”) payable in equal
installments in accordance with the normal payroll policies of the Company, with the first installment being paid on the Company’s
first regular pay date on or after the sixtieth (60th) day following the termination of employment, which initial payment
shall include all installment amounts that would have been paid during the first sixty (60) days following the termination of employment
had installments commenced immediately following the termination date, (d) during the Severance Period or until the Executive becomes
eligible for comparable employer sponsored health plan benefits, whichever is sooner, all health plan benefits to which the Executive
is entitled prior to the termination date under any such benefit plans or arrangements maintained by the Company in which the Executive
participated, which benefits shall be determined and paid in accordance with this Agreement and plans or arrangements and shall
be provided pursuant to COBRA with the relative costs therefor being paid by the Company and the Executive in the same proportion
as existed while the Executive was an active employee of the Company; and (e) the Stock Options and Restricted Stock granted to
the Executive shall be fully and immediately vested, and the Stock Options shall remain exercisable for two (2) years following
the termination date or, if sooner, until the end of the applicable Stock Option’s term. For purposes of this Agreement,
“Good Reason” means termination because of: (a) a material diminution without the Executive’s consent
in the Executive’s duties and responsibilities; and (b) a material breach by the Company of this Agreement or any other agreement
to which the Executive and the Company are parties. In each such event listed above, the Executive shall give the Company written
notice thereof which shall specify in reasonable detail the circumstances constituting Good Reason, and there shall be no Good
Reason with respect to any such circumstances if cured by the Company within thirty (30) days after such notice.

 

C.           Survival.
The Executive’s post-termination obligations in Article IV shall continue as provided in this Agreement.

 

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ARTICLE IV.

Restrictive Covenants

 

A.           Confidentiality.

 

(i)          Confidential
Information. During the Executive’s employment with the Company, the Company shall grant the Executive otherwise
prohibited access to its trade secrets and confidential information which is not known to the Company’s competitors or within
the Company’s industry generally, which was developed by the Company over a long period of time and/or at its substantial
expense, and which is of great competitive value to the Company, and access to the Company’s customers and clients. For purposes
of this Agreement, “Confidential Information” includes any trade secrets or confidential or proprietary
information of the Company, including, but not limited to, the following: methods of operation, products, inventions, services,
processes, equipment, know-how, technology, technical data, policies, strategies, designs, formulas, developmental or experimental
work, improvements, discoveries, research, plans for research or future products and services, database schemas or tables, software,
development tools or techniques, training procedures, training techniques, training manuals, business information, marketing and
sales methods, plans and strategies, competitors, markets, market surveys, techniques, production processes, infrastructure, business
plans, distribution and installation plans, processes and strategies, methodologies, budgets, financial data and information, customer
and client information, prices and costs, fees, customer and client lists and profiles, employee, customer and client nonpublic
personal information, supplier lists, business records, product construction, product specifications, audit processes, pricing
strategies, business strategies, marketing and promotional practices, management methods and information, plans, reports, recommendations
and conclusions, information regarding the skills and compensation of employees and contractors of the Company, and other business
information disclosed to the Executive by the Company, either directly or indirectly, in writing, orally, or by drawings or observation.
“Confidential Information” does not include, and there shall be no obligation hereunder with respect
to, information that (i) is generally available to the public on the date of this Agreement or (ii) becomes generally available
to the public other than as a result of a disclosure not otherwise permissible hereunder.

 

(ii)         No
Unauthorized Use or Disclosure. The Executive acknowledges and agrees that Confidential Information is proprietary to and
a trade secret of the Company and, as such, is a special and unique asset of the Company, and that any disclosure or unauthorized
use of any Confidential Information by the Executive will cause irreparable harm and loss to the Company. The Executive understands
and acknowledges that each and every component of the Confidential Information (i) has been developed by the Company at significant
effort and expense and is sufficiently secret to derive economic value from not being generally known to other parties, and (ii)
constitutes a protectable business interest of the Company. The Executive acknowledges and agrees that the Company owns the Confidential
Information. The Executive agrees not to dispute, contest, or deny any such ownership rights either during or after the Executive’s
employment with the Company. The Executive agrees to preserve and protect the confidentiality of all Confidential Information.
The Executive agrees that the Executive shall not during the period of the Executive’s employment with the Company and thereafter,
directly or indirectly, disclose to any unauthorized person or use for the Executive’s own account any Confidential Information
without the Company’s consent. Throughout the Executive’s employment with the Company thereafter: (i) the Executive
shall hold all Confidential Information in the strictest confidence, take all reasonable precautions to prevent its inadvertent
disclosure to any unauthorized person, and follow all Company policies protecting the Confidential Information; and (ii) the Executive
shall not, directly or indirectly, utilize, disclose or make available to any other person or entity, any of the Confidential Information,
other than in the proper performance of the Executive’s duties.

 

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(iii)        Return
of Property and Information.  Upon the termination of the Executive’s employment for any reason, the Executive
shall immediately return and deliver to the Company any and all Confidential Information, software, devices, cell phones, personal
data assistants, credit cards, data, reports, proposals, lists, correspondence, materials, equipment, computers, hard drives, papers,
books, records, documents, memoranda, manuals, e-mail, electronic or magnetic recordings or data, including all copies thereof,
which belong to the Company or relate to the Company’s business and which are in the Executive’s possession, custody
or control, whether prepared by the Executive or others. If at any time after termination of the Executive’s employment the
Executive determines that the Executive has any Confidential Information in the Executive’s possession or control, the Executive
shall immediately return to the Company all such Confidential Information in the Executive’s possession or control, including
all copies and portions thereof.

 

B.           Restrictive
Covenants. In consideration for (i) the Company’s promise to provide Confidential Information to the Executive, (ii)
the substantial economic investment made by the Company in the Confidential Information and goodwill of the Company, and/or the
business opportunities disclosed or entrusted to the Executive, (iii) access to the Company’s customers and clients, and
(iv) the Company’s employment of the Executive pursuant to this Agreement and the compensation and other benefits provided
by the Company to the Executive, to protect the Company’s Confidential Information and business goodwill of the Company,
the Executive agrees to the following restrictive covenants:

 

(i)          Non-Competition.
The Executive agrees that during the Restricted Period (defined below), other than in connection with the Executive’s duties
under this Agreement (including, without limitation, services to affiliates of the Company), the Executive shall not, and shall
not use any Confidential Information to, without the prior written consent of the Company, directly or indirectly, either individually
or as a principal, partner, stockholder, manager, agent, consultant, contractor, distributor, employee, lender, investor, or as
a director or officer of any corporation or association, or in any other manner or capacity whatsoever, become employed by, control,
manage, carry on, join, lend money for, operate, engage in, establish, perform services for, invest in, solicit investors for,
consult for, do business with or otherwise engage in any Competing Business. Notwithstanding the restrictions contained in this
Article IV.B.(i), the Executive may own an aggregate of not more than two percent (2%) of the outstanding stock of any class
of any corporation engaged in a Competing Business, if such stock is listed on a national securities exchange in the United States
(or a comparable exchange in a foreign jurisdiction) or regularly traded in the over-the-counter market by a member of a national
securities exchange in the United States, without violating the provisions of Article IV.B.(i).

 

For purposes of this Agreement:

 

(a)          “Restricted
Period” means during the Executive’s employment with the Company and for a period of twelve (12) months immediately
following the date of Executive’s termination from employment for any reason.

 

(b)          “Competing
Business” means any business, individual, partnership, firm, corporation or other entity that is competing with any
aspect of the Company’s business of providing wound care products, treatments, technologies or solutions.

 

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(ii)         Non-Solicitation.
The Executive agrees that during the Restricted Period, other than in connection with Executive’s duties under this Agreement,
the Executive shall not, and shall not use any Confidential Information to, directly or indirectly, either as a principal, manager,
agent, employee, consultant, officer, director, stockholder, partner, investor or lender or in any other capacity, and whether
personally or through other persons:

 

(a)          Solicit
business from, interfere with, induce, attempt to solicit business with, interfere with, induce or do business with any actual
or prospective customer, client, supplier (including any content providers), manufacturer, vendor or licensor of the Company with
whom the Company did business, and who or which: (1) the Executive contacted, called on, serviced or did business with during
the Executive’s employment with the Company; (2) the Executive learned of as a result of the Executive’s employment
with the Company; or (3) about whom the Executive received Confidential Information. This restriction applies only to business
which is in the scope of services or products provided by the Company or any affiliate thereof; or

 

(b)          Solicit,
induce or attempt to solicit or induce, engage or hire, on behalf of the Executive or any other person or entity, any person who
is an employee or consultant of the Company or who was employed by the Company within the preceding twelve (12) months.

 

C.           Works.

 

(i)          Assignment
of Work Product. For the purposes of this Agreement, the term “Work Product” shall mean, collectively,
all work product, information, inventions, original works of authorship, ideas, know-how, processes, designs, computer programs,
photographs, illustrations, developments, trade secrets and discoveries, including improvements thereto, that the Executive conceives,
creates, develops, makes, reduces to practice, or fixes in a tangible medium of expression, either alone or with others. During
the Restricted Period, the Executive agrees that the Executive shall promptly make full written disclosure to the Company of all
Work Product conceived, created, developed, made, reduced to practice, or fixed in a tangible medium of expression during the period
of the Executive’s employment with the Company. Executive hereby assigns and shall be deemed to have assigned to the Company
or its designee, all of the Executive’s right, title, and interest in and to any and all Work Product conceived, created,
developed, made, reduced to practice, or fixed in a tangible medium of expression during the period of the Executive’s employment
the Company that (a) relates in any manner to the previous, existing or contemplated business, work, or investigations of the Company;
(b) is or was suggested by, has resulted or will result from, or has arisen or will arise out of any work that the Executive has
done or may do for or on behalf of the Company; (c) has resulted or will result from or has arisen or will arise out of any materials
or information that may have been disclosed or otherwise made available to the Executive as a result of duties assigned to the
Executive by the Company; or (d) has been or will be otherwise made through the use of the Company’s time, information, facilities,
or materials, even if conceived, created, developed, made, reduced to practice, or fixed during other than working hours. The Executive
further acknowledges that all original works of authorship that have been or will be made or fixed in a tangible medium of expression
by the Executive (solely or jointly with others) within the scope of the Executive’s employment with the Company that are
protectable by copyright are “Works Made for Hire,” as that term is defined in the United States Copyright Act. The
Executive understands and agrees that the decision whether or not to commercialize or market any Work Product is within the Company’s
sole discretion and for the Company’s sole benefit, and that no royalty will be due to the Executive as a result of the Company’s
efforts to commercialize or market any such Work Product.

 

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(ii)         Patent
and Copyright Registrations. The Executive agrees to assist the Company, or its designee, at the Company’s expense,
in every proper way to secure the Company’s rights in Work Product in any and all countries, including the disclosure to
the Company of all pertinent information and data with respect thereto, the execution of all applications, specifications, oaths,
assignments, affidavits, and all other instruments which the Company shall deem necessary in order to apply for and obtain such
rights and in order to assign and convey to the Company, its successors, assigns, and nominees the sole and exclusive rights, title
and interest in and to such Work Product. The Executive further agrees that the Executive’s obligation to execute or cause
to be executed, when it is in the Executive’s power to do so, any such instrument or papers shall continue after the termination
of this Agreement.

 

D.           Tolling.
If the Executive violates any of the restrictions contained in this Article IV, the Restricted Period shall be suspended
and shall not run in favor of the Executive from the time of the commencement of any violation until the time when the Executive
cures the violation to the satisfaction of the Company.

 

E.           Remedies.
The Executive acknowledges that the restrictions contained in Article IV of this Agreement, in view of the nature of the
Company’s business and the Executive’s position with the Company, are reasonable and necessary to protect the Company’s
legitimate business interests and that any violation of Article IV of this Agreement would result in irreparable injury
to the Company. In the event of a breach by the Executive of Article IV of this Agreement, then the Company shall be entitled
to a temporary restraining order and injunctive relief restraining the Executive from the commission of any breach. Such remedies
shall not be deemed the exclusive remedies for a breach or threatened breach of this Article IV but shall be in addition
to all remedies available at law or in equity, including the recovery of damages from the Executive, the Executive’s agents,
any future employer of the Executive, and any person that conspires or aids and abets the Executive in a breach or threatened breach
of this Agreement.

 

F.           Reasonableness.
The Executive hereby represents to the Company that the Executive has read and understands, and agrees to be bound by, the terms
of this Article IV. The Executive acknowledges that the geographic scope and duration of the covenants contained in this
Article IV are fair and reasonable in light of (i) the nature and wide geographic scope of the operations of the Company’s
business; (ii) the Executive’s level of control over and contact with the business in the Restricted Area; and (iii) the
amount of compensation, trade secrets and Confidential Information that the Executive is receiving in connection with the Executive’s
employment by the Company.

 

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G.           Reformation.
If any of the aforesaid restrictions are found by a court of competent jurisdiction to be unreasonable, or overly broad as to geographic
area or time, or otherwise unenforceable, the Parties intend for the restrictions herein set forth to be modified by the court
making such determination so as to be reasonable and enforceable and, as so modified, to be fully enforced. By agreeing to this
contractual modification prospectively at this time, the Company and the Executive intend to make this provision enforceable under
the law or laws of all applicable jurisdictions so that the entire agreement not to compete and this Agreement as prospectively
modified shall remain in full force and effect and shall not be rendered void or illegal.

 

H.           No
Previous Restrictive Agreements. The Executive represents that, except as disclosed to the Company, the Executive is not
bound by the terms of any agreement with any previous employer or other party to refrain from using or disclosing any trade secret
or confidential or proprietary information in the course of the Executive’s employment with the Company or to refrain from
competing, directly or indirectly, with the business of such previous employer or any other party. The Executive further represents
that the Executive’s performance of all the terms of this Agreement and the Executive’s work duties for the Company
do not and will not breach any agreement to keep in confidence proprietary information, knowledge or data acquired by the Executive
in confidence or in trust prior to the Executive’s employment with the Company. The Executive shall not disclose to the Company
or induce the Company to use any confidential or proprietary information or material belonging to any previous employer or others.

 

ARTICLE V.

Miscellaneous Provisions

 

A.           Governing
Law. This Agreement shall be governed by and construed under the laws of the State of Delaware. Venue of any litigation
arising from this Agreement or any disputes relating to the Executive’s employment shall be in the United States District
Court for the District of Delaware, or a state district court of competent jurisdiction in New Castle County, Delaware. The Executive
consents to personal jurisdiction of the United States District Court for the District of Delaware, or a state district court of
competent jurisdiction in New Castle County, Delaware for any dispute relating to or arising out of this Agreement or the Executive’s
employment, and the Executive agrees that the Executive shall not challenge personal or subject matter jurisdiction in such courts.

 

B.           Headings.
The paragraph headings contained in this Agreement are for convenience only and shall in no way or manner be construed as a part
of this Agreement.

 

C.           Severability.
In the event that any court of competent jurisdiction holds any provision in this Agreement to be invalid, illegal or unenforceable
in any respect, the remaining provisions shall not be affected or invalidated and shall remain in full force and effect.

 

D.           Reformation.
In the event any court of competent jurisdiction holds any restriction in this Agreement to be unreasonable and/or unenforceable
as written, the court may reform this Agreement to make it enforceable, and this Agreement shall remain in full force and effect
as reformed by the court.

 

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E.           Entire
Agreement. This Agreement constitutes the entire agreement between the Parties, and fully supersedes any and all prior
agreements, understanding or representations between the Parties pertaining to or concerning the subject matter of this Agreement,
including, without limitation, the Executive’s employment with the Company. No oral statements or prior written material
not specifically incorporated in this Agreement shall be of any force and effect, and no changes in or additions to this Agreement
shall be recognized, unless incorporated in this Agreement by written amendment, such amendment to become effective on the date
stipulated in it. Any amendment to this Agreement must be signed by all parties to this Agreement. The Executive acknowledges and
represents that in executing this Agreement, the Executive did not rely, and has not relied, on any communications, promises, statements,
inducements, or representation(s), oral or written, by the Company, except as expressly contained in this Agreement. The Parties
represent that they relied on their own judgment in entering into this Agreement.

 

F.           Waiver.
No waiver of any breach of this Agreement shall be construed to be a waiver as to succeeding breaches. The failure of either party
to insist in any one or more instances upon performance of any terms or conditions of this Agreement shall not be construed as
a waiver of future performance of any such term, covenant or condition but the obligations of either party with respect thereto
shall continue in full force and effect. The breach by one party to this Agreement shall not preclude equitable relief or the obligations
in Article IV.

 

G.           Modification.
The provisions of this Agreement may be amended, modified or waived only with the prior written consent of the Company and the
Executive, and no course of conduct or failure or delay in enforcing the provisions of this Agreement shall be construed as a waiver
of such provisions or affect the validity, binding effect or enforceability of this Agreement or any provision hereof.

 

H.           Assignment.
This Agreement shall be binding upon and inure to the benefit of the Parties hereto and their respective heirs, successors and
permitted assigns. The Executive may not assign this Agreement to a third party. The Company may assign its rights, together with
its obligations hereunder, to any affiliate and/or subsidiary of the Company or any successor thereto or any purchaser of substantially
all of the assets of the Company.

 

I.           Code
Section 409A.

 

(i)          To
the extent (A) any payments to which the Executive becomes entitled under this Agreement, or any agreement or plan referenced herein,
in connection with the Executive’s termination of employment with the Company constitute deferred compensation subject to
Section 409A of the Internal Revenue Code of 1986, as amended (the “Code”); (B) the Executive is deemed
at the time of his separation from service to be a “specified employee” under Section 409A of the Code; and (C) at
the time of the Executive’s separation from service the Company is publicly traded (as defined in Section 409A of Code),
then such payments (other than any payments permitted by Section 409A of the Code to be paid within six (6) months of the Executive’s
separation from service) shall not be made until the earlier of (1) the first day of the seventh month following the Executive’s
separation from service or (2) the date of the Executive’s death following such separation from service. Upon the expiration
of the applicable deferral period, any payments which would have otherwise been made during that period (whether in a single sum
or in installments) in the absence of this Article V, Section I shall be paid to the Executive or the Executive’s
beneficiary in one lump sum, plus interest thereon at the Delayed Payment Interest Rate (as defined below) computed from the date
on which each such delayed payment otherwise would have been made to the Executive until the date of payment. For purposes of the
foregoing, the “Delayed Payment Interest Rate” shall mean the national average annual rate of interest
payable on jumbo six-month bank certificates of deposit, as quoted in the business section of the most recently published Sunday
edition of The New York Times preceding the Executive’s separation from service.

 

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(ii)         To
the extent any benefits provided under Article III, Section B(ii) above are otherwise taxable to the Executive, such benefits
shall, for purposes of Section 409A of the Code, be provided as separate in-kind payments of those benefits, and the provision
of in-kind benefits during one calendar year shall not affect the in-kind benefits to be provided in any other calendar year.

 

(iii)        In
the case of any amounts payable to the Executive under this Agreement, or under any plan of the Company, that may be treated as
payable in the form of “a series of installment payments,” as defined in Treas. Reg. §1.409A-2(b)(2)(iii), the
Executive’s right to receive such payments shall be treated as a right to receive a series of separate payments for purposes
of Treas. Reg. §1.409A-2(b)(2)(iii).

 

(iv)        It
is intended that this Agreement comply with or be exempt from the provisions of Section 409A of the Code and the Treasury Regulations
and guidance of general applicability issued thereunder, and in furtherance of this intent, this Agreement shall be interpreted,
operated, and administered in a manner consistent with such intent.

 

[REMAINDER OF PAGE INTENTIONALLY LEFT BLANK.
SIGNATURE PAGE FOLLOWS.]

 

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IN WITNESS WHEREOF,
the Company and the Executive have caused this Agreement to be executed on the date first set forth above, to be effective as of
that date.

 

	EXECUTIVE:	 
	 	 
	/s/ Bradford C. Barton	 
	Bradford C. Barton	 
	 	 
	COMPANY:	 
	 	 
	Alliqua Biomedical, Inc.	 
	 	 
	By:	/s/ David Johnson	 
	 	David Johnson	 
	 	Chief Executive Officer	 

 

Signature Page to Employment AgreementEX-10.1

 Exhibit 10.1 

FIRST AMENDMENT 
 TO

 SECOND AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT 

THIS FIRST AMENDMENT to Second Amended and Restated Loan and Security Agreement (this “Amendment”) is entered into as
of June 5, 2015, by and between Silicon Valley Bank (“Bank”) and Ignyta, Inc., a Delaware corporation (“Borrower”). 

RECITALS 

A. Bank and Borrower have entered into that certain Second Amended and Restated Loan and Security Agreement dated as of
September 30, 2014 (as the same may from time to time be further amended, modified, supplemented or restated, the “Loan Agreement”). 

B. Bank has extended credit to Borrower for the purposes permitted in the Loan Agreement. 

C. Borrower has requested that Bank amend the Loan Agreement to make certain revisions as more fully set forth herein. 

D. Bank has agreed to so amend certain provisions of the Loan Agreement, but only to the extent, in accordance with the terms, subject
to the conditions and in reliance upon the representations and warranties set forth below. 
 AGREEMENT

 NOW, THEREFORE, in consideration of the foregoing recitals and other good and valuable
consideration, the receipt and adequacy of which is hereby acknowledged, and intending to be legally bound, the parties hereto agree as follows: 

1. Definitions. Capitalized terms used but not defined in this Amendment shall have the meanings given to them in the Loan Agreement.

 2. Amendments to Loan Agreement. 

2.1 Section 13 (Definitions). The following term and its respective definition set forth in Section 13.1 is
amended in its entirety and replaced with the following: 
 “Term B Draw Event” means Bank’s receipt of evidence, in
form and substance reasonably satisfactory to Bank, of the initiation of any Phase 2 clinical trial for Borrower’s product candidate entrectinib (formerly called RXDX-101).” 

3. Limitation of Amendments. 

3.1 The amendments set forth in Section 2, above, are effective for the purposes set forth herein and shall be limited precisely
as written and shall not be deemed to (a) be a consent to any amendment, waiver or modification of any other term or condition of any Loan Document, or (b) otherwise prejudice any right or remedy which Bank may now have or may have in the
future under or in connection with any Loan Document. 
 3.2 This Amendment shall be construed in connection with and as part of the
Loan Documents and all terms, conditions, representations, warranties, covenants and agreements set forth in the Loan Documents, except as herein amended, are hereby ratified and confirmed and shall remain in full force and effect. 

4. Representations and Warranties. To induce Bank to enter into this Amendment, Borrower hereby represents and warrants to Bank as
follows: 
 4.1 Immediately after giving effect to this Amendment (a) the representations and warranties

 
contained in the Loan Documents are true, accurate and complete in all material respects as of the date hereof (except to the extent such representations and warranties relate to an earlier date,
in which case they are true and correct as of such date), and (b) no Event of Default has occurred and is continuing; 
 4.2
Borrower has the power and authority to execute and deliver this Amendment and to perform its obligations under the Loan Agreement, as amended by this Amendment; 

4.3 The organizational documents of Borrower delivered to Bank on the Effective Date remain true, accurate and complete and have not
been amended, supplemented or restated and are and continue to be in full force and effect; 
 4.4 The execution and delivery by
Borrower of this Amendment and the performance by Borrower of its obligations under the Loan Agreement, as amended by this Amendment, have been duly authorized; 

4.5 The execution and delivery by Borrower of this Amendment and the performance by Borrower of its obligations under the Loan
Agreement, as amended by this Amendment, do not and will not contravene (a) any law or regulation binding on or affecting Borrower, (b) any material contractual restriction with a Person binding on Borrower, (c) any order, judgment or
decree of any court or other governmental or public body or authority, or subdivision thereof, binding on Borrower, or (d) the organizational documents of Borrower; 

4.6 The execution and delivery by Borrower of this Amendment and the performance by Borrower of its obligations under the Loan
Agreement, as amended by this Amendment, do not require any order, consent, approval, license, authorization or validation of, or filing, recording or registration with, or exemption by any governmental or public body or authority, or subdivision
thereof, binding on either Borrower, except as already has been obtained or made; and 
 4.7 This Amendment has been duly executed and
delivered by Borrower and is the binding obligation of Borrower, enforceable against Borrower in accordance with its terms, except as such enforceability may be limited by bankruptcy, insolvency, reorganization, liquidation, moratorium or other
similar laws of general application and equitable principles relating to or affecting creditors’ rights. 
 5. Integration. This
Amendment and the Loan Documents represent the entire agreement about this subject matter and supersede prior negotiations or agreements. All prior agreements, understandings, representations, warranties, and negotiations between the parties about
the subject matter of this Amendment and the Loan Documents merge into this Amendment and the Loan Documents. 
 6. Counterparts.
This Amendment may be executed in any number of counterparts and all of such counterparts taken together shall be deemed to constitute one and the same instrument. 

7. Effectiveness. This Amendment shall be deemed effective upon (a) the due execution and delivery to Bank of this Amendment by
each party hereto and (b) Borrower’s payment of an amount equal to all Bank Expenses incurred through the date of this Amendment. 

[Signature page follows] 

 IN WITNESS WHEREOF, the parties hereto have
caused this Amendment to be duly executed and delivered as of the date first written above. 
  

			
	BANK		BORROWER
		
	 Silicon Valley Bank
  

By: /s/ Anthony Flores
 Name: Anthony Flores

Title: Vice President
		 Ignyta, Inc.
  

By: /s/ Matthew Onaitis
 Name: Matthew Onaitis

Title: General Counsel

 [Signature page to First Amendment to Second Amended and Restated Loan and Security
Agreement]

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