Document:

<PAGE>

                                                                   EXHIBIT 10.43
                                                                   -------------

                               LICENSE AGREEMENT
                               -----------------

     THIS PRODUCT PURCHASE AND LICENSE AGREEMENT (the "Agreement") is made
effective as of June 19, 2001 (the "Effective Date"), by and among Dean Edell
("Edell"), HealthCentral.com, a Delaware corporation ("HealthCentral"), and
Sunglass Products Of California, a California corporation ("Cable Car").

                                    RECITALS

     A. On April 11, 2000, Edell, Brand Optical Corporation ("Brand Optical")
and HealthCentral entered into an Assignment and Amendment Agreement whereby the
license to utilize the "Dr. Dean Edell" trademark, name and likeness
(collectively, the "Edell Marks") were assigned from Brand Optical to
HealthCentral. The term of the Assignment and Amendment Agreement extends
through December 31, 2006 and grants to HealthCentral, among other rights, the
right to sublicense the Edell Marks.

     B. Pursuant to the Sales and Distribution Agreement, by and between
HealthCentral and Cable Car, dated April 11, 2000, HealthCentral granted to
Cable Car the exclusive right to purchase eyewear products including, without
limitation, reading glasses and sunglasses bearing or utilizing the "Dr. Dean
Edell" name (the "Products") for sale to physical, brick-and-mortar, retail
locations as well as mail order and internet distribution channels operated on
behalf of Cable Car's customers who operate physical, brick-and-mortar retail
locations or as otherwise approved by HealthCentral (collectively, the "Field").
Pursuant to the Sales and Distribution Agreement, HealthCentral agreed not to
sell Products, directly or indirectly, other than through Cable Car, to
purchasers in the Field. Cable Car agreed, in the Sales and Distribution
Agreement, that, except in the event of a default thereunder, it would purchase
the Products from HealthCentral.

NOW, THEREFORE, for good and valuable consideration, the receipt and sufficiency
of which are hereby acknowledged, the parties agree as follows:

                                   AGREEMENT

                                   ARTICLE I
                              LICENSE AND ROYALTY
                              -------------------

1.1.  Grant of License.  HealthCentral hereby grants to Cable Car the exclusive
      ----------------
right (the "License") to manufacture, distribute, market and sell reading
glasses and sunglasses under the Edell Marks within the United States, Canada,
Mexico and Puerto Rico (collectively, the "Territory") during the period from
the Effective Date through December 31, 2006 and any extension thereof (the
"License Term").  In the event that HealthCentral extends its agreement
<PAGE>

with Edell, HealthCentral agrees to automatically extend this agreement for a
like period of time.

1.2.  HealthCentral to Use Best Efforts to Facilitate License Extension.
      -----------------------------------------------------------------
HealthCentral agrees that it will use its best efforts to facilitate in a timely
manner an extension to the License to the Dr. Dean Edell Eyewear Brand, in
conjunction with Edell, and that HealthCentral will allow Cable Car to contract
directly with Edell in this regard.  The anticipated extension is expected to be
for *** Edell anticipates receiving in return for the license extension the
greater of  *** annually or ***  during the extension time period.  Payments to
Edell will be made by Cable Car quarterly within ***  of each quarter's end.

1.3.  Trademark and License Rights.
      ----------------------------

      (a)  HealthCentral. HealthCentral hereby represents and warrants that it
owns the exclusive license to use the Edell Marks in the Field and Territory,
and that it has all right, title and interest in and to the Edell Marks
necessary to grant the License to Cable Car.

      (b)  Edell. Edell hereby represents and warrants that he is the owner of
           -----
all right, title and interest, other than the rights held by HealthCentral
described above and in the Assignment and Amendment Agreement, in and to the
Edell Marks.

1.4.  Indemnification.  HealthCentral and Edell shall each indemnify Cable Car
      ---------------
and shall hold it harmless from any loss, liability, damage, cost, or expense
including, without limitation, attorneys' fees arising out of any claims or
suits which may be brought or made against Cable Car by reason of the breach by
HealthCentral or Edell of their respective representations and warranties set
forth in Section 1.3 above, provided that Cable Car shall give prompt written
notice and full cooperation and assistance to Health Central or Edell, as the
case may be, relative to any such claim or suit.

*** Material has been omitted pursuant to a request for confidential treatment.
<PAGE>

1.5.  Royalty.
      -------

      (a)  In consideration of the License granted hereunder, during the License
Term Cable Car shall pay to HealthCentral a royalty equal to *** (the
"Royalty"). As used herein, "Net Sales of Products" shall mean the aggregate of
Cable Car's net invoice price for sales of the Products less (i) any taxes
included in the net invoice price; (ii) actual shipping and handling costs paid
to a third party; (iii) returns of products; and (iv) discounts and allowances
provided in good faith by Cable Car. This obligation is limited to product
purchased after March 31, 2001 by Cable Car from third party suppliers and sold
to its customers. Additionally, on a quarterly basis, beginning April 1, 2001,
Cable Car will pay a contract maintenance fee (the "Maintenance Fee") of *** in
arrears.

      (b)  The Royalty and Maintenance Fee shall be payable to HealthCentral
quarterly within 45 days of the end of each calendar quarter for Net Sales of
Products during the calendar quarter just ended (the "Quarterly Payment"). That
is, Quarterly Payment shall be due on May 15 (for sales occurring in the first
calendar quarter), August 14 (for sales occurring in the second calendar
quarter), November 14 (for sales occurring in the third calendar quarter), and
February 14 (for sales occurring in the fourth calendar quarter of the previous
year).

     (c)  In addition to each Quarterly Payment of the Royalty, Cable Car shall
submit a statement of Net Sales of Products during the calendar quarter just
ended certified by its President or Treasurer which statement shall detail the
sales of the Products, taxes, shipping and handling, returns of products, and
discounts and allowances provided in good faith by Cable Car.

     (d)  For the sole purpose of ensuring compliance with this Article I, and
no more than once in any calendar year and upon no less than ten (10) business
days' prior written request, Cable Car shall provide HealthCentral with
information relevant to the verification of the amounts payable under this
Section 1.5 and solely to the extent necessary to allow an independent certified
public accounting firm chosen and compensated by HealthCentral to audit such
information; provided however, that the independent auditor agrees to maintain
the Confidentiality of any information provided by Cable Car. Any such access
requested by HealthCentral shall occur during normal business hours. Cable Car
shall have 30 days following its receipt from HealthCentral of the results of
such audit to challenge the results. If such audit reveals an underpayment, then
Cable Car shall promptly pay the outstanding amounts, and if the underpayment
exceeds ***, then Cable Car will also reimburse HealthCentral for the costs of
such audit.

1.6.  First Right of Negotiation.  In the event HealthCentral desires to appoint
      --------------------------
a distributor for the Products outside of the Territory, Cable Car will be given
the first opportunity to negotiate an acceptable agreement to be such
representative.

*** Material has been omitted pursuant to a request for confidential treatment.
<PAGE>

1.7.  Minimum Requirements.  Cable Car agrees to pay an annual minimum dollar
      --------------------
amount in the Royalty and Maintenance Fee as listed in Schedule B hereto
("Minimum Royalty and Maintenance Fee Payment Requirements").  The minimum
----------------------------------------------------------
amounts shall be invalid if the FDA or other such government agency prohibits or
significantly restricts the sale of reading glasses.  If Dr. Dean Edell becomes
incapacitated or his public or commercial appeal declines and as a result there
is a substantial decline in sales as agreed upon by the parties the minimum
amounts shall be invalid.
<PAGE>

                                   ARTICLE II
                                     PRODUCT
                                     -------

2.1.  Product.  HealthCentral is authorized to sell inventory it holds on March
      -------
31, 2001 through any channel that is available to liquidate its inventory
holdings other than to current significant customers of Cable Car as listed on
Schedule A attached hereto, or to other entities that, to HealthCentral's
knowledge, intend to sell to significant customers of Cable Car.  The sales may
be made at any price acceptable to HealthCentral.

After such inventory is liquidated, HealthCentral may only sell Products via its
on-line pharmacy, and through any owned retail channels including catalogs and
stores.  If HealthCentral sells Products and periodic discount promotions exceed
*** of the total until sales in any given quarter, Cable Car will be entitled to
a credit for an amount equal to the average discount from the suggested retail
price for those products that exceed the *** of total units threshold.
HealthCentral will provide Cable Car with quarterly sales reports which detail
sales amounts, units and average discounts. Cable Car shall have the right to
audit this information in a process similar to the one described in 1.5(d).

In the event that HealthCentral is unable to sell its existing inventory through
its own efforts, and HealthCentral has sufficient inventory of items in the then
current line and can timely fulfill Cable Car's orders in accordance with
section 2.2, beginning January 2002 and continuing at least through December
2003, Cable Car will purchase *** of product per month from HealthCentral. After
December 2003, Cable Car agrees to use its best efforts to purchase Products
from the HealthCentral inventory, before purchasing such products from any other
sources. The price to Cable Car does not include any federal, state or local
taxes directly applicable to the sale by HealthCentral to Cable Car of the
Products. When HealthCentral has the legal obligation to collect such taxes, the
appropriate amount shall be added to Cable Car's invoice and paid by Cable Car
unless Cable Car provides HealthCentral with a valid tax exemption certificate
authorized by the appropriate taxing authority. Such purchase requirements shall
be terminated if the Federal Drug Administration or any other governmental
agency prohibits or significantly restricts the sale of the Products.

2.2.  Shipping.  Cable Car shall deliver purchase orders to HealthCentral for
      --------
any Products purchased by Cable Car from HealthCentral.  Such Products shall be
delivered F.O.B Hollister, CA by HealthCentral to Cable Car prepackaged,
suitably packed and ready for shipment to Cable Car's customers on the date
specified in the purchase order.  Title to the Products so purchased shall pass
to Cable Car upon physical delivery by HealthCentral or its designated courier
to Cable Car's designated facility as set forth on the purchase order.

2.3.  Rejection and Returns.  Cable Car shall inspect all Products promptly upon
      ---------------------
receipt thereof and may reject any Product that fails to meet the relevant
specifications.  Any Product not properly rejected within 30 days of receipt of
that Product by Cable Car (the "Rejection Period") shall be deemed accepted.  To
                                ----------------
reject a Product, Cable Car must, within the Rejection

*** Material has been omitted pursuant to a request for confidential treatment.
<PAGE>

Period, notify HealthCentral of its rejection and detail the reasons for such
rejection.  As promptly as possible but no later than 30 working days after
receipt of properly rejected Products, HealthCentral shall, at its option and
expense, replace the Products.  HealthCentral shall pay the shipping charges
back to Cable Car for properly rejected Products.  In the event that
HealthCentral does not timely replace the rejected Products, Cable Car shall
have the right to cancel the purchase order and source product elsewhere.

2.4.  Invoicing.  Beginning when Cable Car places its first order for Product
      ---------
from HealthCentral pursuant to this Section 2, HealthCentral will prepare and
deliver to Cable Car weekly invoices for Products shipped to Cable Car.

2.5.  Payment.  For future purchases of Product from HealthCentral, after the
      -------
date of this agreement, full payment for invoices shall be in United States of
America dollars.  Payment terms shall be *** and payment shall be made by wire
transfer, check or other instrument approved by HealthCentral.  Any invoiced
amount not paid when due shall be subject to a service charge at *** per month.
If Cable Car fails to timely make any payment to HealthCentral, HealthCentral
may cancel or delay any future shipments to Cable Car until such delinquent
payment is made, in addition to any other remedies HealthCentral may have.

                                  ARTICLE III
                              TERM AND TERMINATION
                              --------------------

3.1.  Term of Agreement.  The parties' respective rights and obligations shall
      -----------------
commence on the Effective Date hereof and continue in full force and effect
until December 31, 2006, unless terminated earlier under the provisions of this
Article III or other applicable termination provision of this Agreement;
provided, however, that if HealthCentral extends its rights to the Edell Marks
for eyewear, HealthCentral agrees to extend the License for the same time period
as the extension obtained by HealthCentral.

3.2.  Termination For Cause.
      ---------------------

      (a)  With respect to Product purchases in accordance with Article I
hereof, if either party defaults in the performance of any material provision of
Article I, then the non-defaulting party may give written notice to the
defaulting party that if the default is not cured within 60 days (the "Cure
Period") the non-defaulting party may, without affecting the remaining
provisions of this Agreement, terminate the provisions of Article I.

      (b)  With respect to the provisions hereof related to the License, if
Cable Car defaults in the performance of its material obligations and has not
cured such default within the Cure Period, then the License granted hereunder
will automatically terminate on the date eighteen (18) months after the end of
the Cure Period. During such period, Cable Car's obligations to pay the Royalty
shall continue and apply to all sales of the Products bearing the Edell Marks
during such period. If HealthCentral defaults in the performance of its material
obligations or there is a breach of a warranty given by HealthCentral hereunder
and HealthCentral has not

*** Material has been omitted pursuant to a request for confidential treatment.
<PAGE>

cured such default within the Cure Period, then Cable Car may, at its sole and
absolute discretion, terminate the License granted hereunder.

3.3.  Termination For Insolvency.  Either party may terminate this Agreement in
      --------------------------
the event that the other party becomes insolvent, files a petition in
bankruptcy, is declared bankrupt, makes an assignment for benefit of creditors
or there is reasonable evidence indicating the imminent possibility of such
filing or assignment, during the term that this Agreement is in effect.
Termination under this provision shall be effective 20 days following written
notice that this Agreement is being terminated for the reason stated in this
Section 3.3.

3.4.  Effect of Termination; Limitation of Liability.  Except as set forth in
      ----------------------------------------------
this Section 3.4, in the event of termination by either party in accordance with
any of the provisions of this Agreement, neither party shall be liable to the
other, because of such termination, for compensation, reimbursement or damages
on account of the loss of prospective profits or anticipated sales or on account
of expenditures, inventory, investments, leases or commitments in connection
with the business or goodwill of HealthCentral or Cable Car.  Sections 3.1, 3.4,
3.5 and Articles IV - VII shall survive termination, as will all obligations
incurred prior to the termination.  Both Cable Car and HealthCentral shall be
entitled to cancel all purchase orders outstanding at the date of termination,
to the extent Products have not been delivered to Cable Car; provided, however,
that, (i) Cable Car is not in material breach of the Agreement; and (ii) subject
to payment in advance to HealthCentral, Cable Car shall be entitled to receive
Products necessary to fulfill valid and binding purchase orders accepted by
Cable Car prior to notification of termination of this Agreement. Prior to
filling orders for such Products, HealthCentral shall be entitled to request and
receive documentary evidence of all such outstanding purchase orders and an
accounting of Cable Car's existing inventory of Products.

3.5.  Post-Termination Use of Materials.  After termination of this Agreement,
      ---------------------------------
neither party shall use any signs, equipment, advertising matter or other
material which refer to or are related to the other party and each party shall
refrain from acts and omissions that indicate or suggest a relationship with the
other party and shall immediately return to the other party all of such other
party's property, promotional material, and proprietary information.

                                   ARTICLE IV
         WARRANTY WITH RESPECT TO PRODUCTS; DISCLAIMER; INDEMNIFICATION
         --------------------------------------------------------------

4.1.  Standard Limited Warranty. HealthCentral warrants to Cable Car that the
      -------------------------
Products purchased from HealthCentral will conform to the specifications
therefor for a period of 30 days from delivery.  This warranty is contingent
upon proper use of the Products in the application for which the Products were
intended and does not cover Products that were modified without HealthCentral's
approval, or that were subjected to unusual physical, chemical or electrical
stress.

4.2.  No Other Warranty.  WITH RESPECT TO THE PRODUCTS, EXCEPT FOR THE EXPRESS
      -----------------
LIMITED WARRANTY SET FORTH ABOVE AND SUBJECT TO THE
<PAGE>

REPRESENTATIONS AND WARRANTIES MADE IN SECTION 1.3 HEREOF, HEALTHCENTRAL GRANTS
NO WARRANTIES FOR THE PRODUCTS, EXPRESS OR IMPLIED, EITHER IN FACT OR BY
OPERATION OF LAW, BY STATUTE OR OTHERWISE, AND HEALTHCENTRAL SPECIFICALLY
DISCLAIMS ANY IMPLIED WARRANTY INCLUDING ANY WARRANTY OF QUALITY, WARRANTY OF
MERCHANTABILITY, OR WARRANTY  OF FITNESS FOR A PARTICULAR PURPOSE.

4.3.  Limitation of Liability. HEALTHCENTRAL'S LIABILITY UNDER THE LIMITED
      -----------------------
WARRANTY SET FORTH IN SECTION 4.1 ABOVE SHALL BE LIMITED TO A REFUND OF THE
CUSTOMER'S PURCHASE PRICE.  IN NO EVENT SHALL HEALTHCENTRAL BE LIABLE TO CABLE
CAR OR ANY THIRD PARTY FOR THE COST OF PROCUREMENT OF SUBSTITUTE GOODS BY CABLE
CAR OR ANY OF ITS CUSTOMERS OR FOR ANY INDIRECT, SPECIAL, EXEMPLARY,
CONSEQUENTIAL OR INCIDENTAL DAMAGES (EVEN IF HEALTHCENTRAL HAS BEEN ADVISED OF
THE POSSIBILITY OF SUCH DAMAGES) ARISING FROM OR RELATING TO PROVIDING THE
PRODUCTS HEREUNDER.

4.4.  Cable Car Warranties.  Cable Car may make warranties on its behalf,
      --------------------
provided that (a) such warranties shall impose no liability on HealthCentral,
and (b) Cable Car shall not make any false or misleading representations to
customers or others regarding the Products.

4.5.  Indemnification.  Cable Car agrees to indemnify and hold HealthCentral,
      ---------------
its officers, directors, and employees and Edell harmless from and against any
and all losses resulting from claims made by any person or entity arising out of
the marketing, distribution, sale or use of the Products (including claims that
the sale or use of the Products infringe upon the intellectual property rights
of a third party other than a claim based on infringement of the Edell Marks,
claims arising from the failure to meet product specifications, and claims based
upon inherent defects). The indemnifying party shall have the right to defend
or, at its option, to settle such claims, and if it chooses to exercise such
right, it shall have sole control over defense of any such claim or settlement
negotiations.
<PAGE>

                                   ARTICLE V
                                    NOTICES
                                    -------

5.1.  Addresses.  All notices given under this Agreement and the provisions
      ---------
contained herein shall be sent by first class registered airmail, postage
prepaid and return receipt requested, by Federal Express, or by Telecopier, or
Facsimile as directed below:

To:            HealthCentral
               Marketplace Tower
               6005 Shellmound Street
               Suite 250
               Emeryville, CA  94608
               Attention:  C. Fred Toney
               Telephone:  (510) 250-2500
               Facsimile:  (510) 250-2703

               when directed to HealthCentral;

To:            Sunglass Products of California
               2501 Ninth Street, Suite 100
               Berkeley, California
               Attention:  Kirk Lyon, John Melin
               Telephone:  (510) 848-4700
               Facsimile:  (510) 848-4090

               when directed to Cable Car; and

To:            Dr. Dean Edell
               65 Moncada Way
               San Rafael, CA 94901
               Telephone:
               Facsimile:

               when directed to Edell.

5.2.  Delivery.  All notices required or permitted to be given under this
      --------
Agreement shall be regarded as properly given by personal service or by
facsimile, certified or registered mail (return receipt requested), or express
courier to the addresses set forth above.
<PAGE>

                                   ARTICLE VI
                            PROPRIETARY INFORMATION
                            -----------------------

6.1.  Confidentiality.  Each party acknowledges that it has or will have access
      ---------------
to valuable proprietary information of the other party, including but not
limited to, technical data and customer and marketing information, all of which
are the property of the other party, have been maintained confidential, and are
used in the course of such other party's business.  Each party shall not, either
during the term of the Agreement or thereafter, disclose the other party's
proprietary information to anyone other than those of its employees having a
need to know and shall refrain from use of such information other than in the
performance of the Agreement.  In addition, the receiving party shall take all
reasonable precautions to protect the value and confidentiality of such
information to the originating party.  All records, files, notes, drawings,
prints, samples, advertising material and the like relating to the business,
products or projects of the originating party and all copies made from such
documents, shall remain the sole and exclusive property of the originating party
and shall be returned to the originating party immediately upon written request
thereby.  Each party agrees to continue to maintain all proprietary information
in confidence for a period of five years following termination of the Agreement,
unless written authorization to so disclose any such information is first
obtained from the originating party hereunder.

6.2.  Non-Proprietary Information.  Neither party shall be obligated or required
      ---------------------------
to maintain in confidence any information which it can demonstrate with written
records (a) is in the public domain or known to the receiving party prior to
disclosure by the originating party, (b) becomes known to the public after
disclosure by the originating party, other than through breach of the Agreement,
(c) becomes known to the receiving party from a source other than the disclosing
party without breach of any obligation of confidence, or (d) is or has been
furnished to a third party by the originating party without restriction on the
third party's right to disclose.

                                  ARTICLE VII
                                 MISCELLANEOUS
                                 -------------

7.1.  Assignment.  A mutually agreed consideration for HealthCentral's and
      ----------
Edell's entering into this Agreement is the reputation, business standing, and
goodwill already honored and enjoyed by Cable Car and, accordingly, Cable Car
agrees that Cable Car's rights and obligations under this Agreement may not be
transferred or assigned directly or indirectly without the prior written consent
of HealthCentral except in connection with the merger of Cable Car into a
successor corporation or the sale of materially all of the assets of Cable Car.
Subject to the foregoing sentences, this Agreement shall be binding upon and
inure to the benefit of the parties hereto and their successors and assigns.

7.2.  Attorney Fees.  The prevailing party in any legal action brought by one
      -------------
party against the other and arising out of this Agreement shall be entitled, in
addition to any other rights and
<PAGE>

remedies that such prevailing party may have, to reimbursement for reasonable
expenses incurred by such prevailing party, including court costs and reasonable
attorneys' fees.

7.3.  Counterparts.  This Agreement may be executed in two or more counterparts,
      ------------
each of which shall be deemed an original and all of which together shall
constitute one instrument.

7.4.  Partial Invalidity.  If any provision of this Agreement is held to be
      ------------------
invalid, then the remaining provisions shall nevertheless remain in full force
and effect. The parties agree to renegotiate in good faith any term held invalid
and to be bound by the mutually agreed upon substitute provision.

7.5.  Titles and Subtitles.  The titles and subtitles used in this Agreement are
      --------------------
used for convenience only and are not to be considered in construing or
interpreting this Agreement.

7.6.  Changes and Additions to Agreement.  This Agreement and the exhibits
      ----------------------------------
hereto constitute the final agreement between the parties and supersede all
prior agreements and understandings, oral or written, all of which are merged
herein.  No modification, assignment, or any future representation, promise or
agreement in connection with the subject matter of the Agreement shall be
binding on HealthCentral, Edell and Cable Car unless made in writing and signed
by an authorized signatory of each.

7.7.  Governing Law and Jurisdiction.  The Agreement shall be governed by, and
      ------------------------------
construed and interpreted in accordance with, the laws of the State of
California, United States of America, without reference to conflict of laws
principles.  Any dispute or claim arising out of or in connection with the
Agreement or the performance, breach or termination thereof, shall be finally
settled in the courts located in or for Alameda County, California.

7.8.  Independent Contractor Relationship.  It is understood that both parties
      -----------------------------------
hereto are independent contractors and engaged in the operation of their own
respective businesses.  Neither party hereto is to be considered the agent of
the other party for any purpose whatsoever, and neither party has any authority,
express or implied, to enter into any contracts or assume any obligations for
the other party, to pledge the credit, or make any warranties or representations
on behalf of the other party except where expressly authorized in writing to do
so.  Nothing in the Agreement or in the activities of either party shall be
deemed to create an agency, partnership, or joint venture relationship.
<PAGE>

     IN WITNESS WHEREOF, the parties have executed this Agreement as of the date
and year first above written.

                                    HEALTHCENTRAL.COM, a Delaware corporation

                                    By: /s/ C. Fred Toney
                                       ---------------------------
                                       C. Fred Toney, President

                                    SUNGLASS PRODUCTS OF CALIFORNIA, a
                                    California corporation

                                    By: /s/ John Melin
                                       ---------------------------
                                       John Melin, Chairman

                                    Confirmed with respect Sections 1.2, 1.3,
                                    1.4, 3.2(b), Article VI and Article VII
                                    only, by:
                                    EDELL

                                     /s/ Dean Edell
                                    ------------------------------
                                    Dean Edell, M.D.
<PAGE>

                                   Schedule A
                        Cable Car Significant Customers
                        -------------------------------

***

*** Material has been omitted pursuant to a request for confidential treatment.
<PAGE>

                                   Schedule B
            Minimum Royalty and Maintenance Fee Payment Requirements
            --------------------------------------------------------

     Year                                   Minimum Royalty and Maintenance Fee
     ----                                   -----------------------------------

     2001                                   ***
     2002                                   ***
     2003                                   ***
     2004                                   ***
     2005                                   ***
     2006                                   ***

*** Material has been omitted pursuant to a request for confidential treatment.<PAGE>

                                                                   EXHIBIT 10.44

                      NOTE AND WARRANT PURCHASE AGREEMENT

          NOTE AND WARRANT PURCHASE AGREEMENT (the "Agreement"), dated as of May
                                                    ---------
10, 2001, by and between HealthCentral.com, a Delaware corporation (the
"Company"), and the persons and entities listed on Exhibit A attached hereto
 -------                                           ---------
(each a "Purchaser" and together the "Purchasers").
         ---------                    ----------

          WHEREAS, the Company desires to issue and sell and the Purchasers
desire to purchase secured promissory notes in substantially the form attached
to this Agreement as Exhibit B (the "Notes") and warrants to purchase Common
                     ---------       -----
Stock of the Company (the "Shares") in substantially the form attached to this
                           ------
Agreement as Exhibit C (the "Warrants").  The Warrants and the Shares are
             ---------       --------
collectively referred to herein as the "Securities."
                                        ----------

          WHEREAS, the Company has agreed to effect the registration of the
Shares under the Securities Act of 1933, as amended (the "Securities Act"),
                                                          --------------
pursuant to a Registration Rights Agreement of even date herewith by and between
the Company and the Purchasers attached hereto as Exhibit D (the "Registration
                                                  ---------       ------------
Rights Agreement"); and
----------------

          WHEREAS, the sale of the Securities by the Company to the Purchasers
will be effected in reliance upon an exemption from securities  registration in
accordance with Section 4(2) of the Securities Act and the rules and regulations
promulgated by the Securities and Exchange Commission (the "Commission") under
                                                            ----------
the Securities Act.

          NOW, THEREFORE, in consideration of the foregoing and the mutual
covenants contained in this Agreement, the Company and the Purchaser hereby
agree as follows:

1.        PURCHASE AND SALE OF THE SHARES.

          1.1  Sale and Issuance of Notes and Warrants.  Subject to the terms
               ---------------------------------------
and conditions of this Agreement, each Purchaser agrees to purchase at the
Closing and the Company agrees to sell and issue to each Purchaser a Note in the
principal amount specified with respect to such Purchaser on Exhibit A to this
                                                             ---------
Agreement, and a Warrant to purchase the number of shares of Common Stock
specified with respect to such Purchaser on Exhibit A to this Agreement, which
                                            ---------
number of shares shall be calculated on the basis of five (5) shares per $1.00
in principal under such Purchaser's Note. The purchase price of each Note shall
be equal to 100% of the principal amount of such Note, and the purchase price of
each Warrant shall be $0.0001 for each share of Common Stock issuable
thereunder. The Company's agreements with each of the Purchasers are separate
agreements, and the sales of the Notes and Warrants to each of the Purchasers
are separate sales.

          (b)  Closing; Delivery.  The purchase and sale of the Notes and
               -----------------
Warrants shall take place in one or more closings (each a "Closing") at the
                                                           -------
offices of Venture Law Group, 2800 Sand Hill Road, Menlo Park, California, at
5:00 p.m., on May 10, 2001, or at such other time and place as the Company and
the Purchasers purchasing the Notes agree upon, orally or in writing,
<PAGE>

provided that at the first such Closing a minimum of $1,000,000 in Notes are
issued and sold to the Purchasers and provided that up to a maximum of
$4,000,000 in aggregate Notes may be issued and sold to the Purchasers (and any
additional Purchasers who may be added to Exhibit A after the date hereof at the
                                          ---------
Company's discretion by executing signature pages to the applicable Transaction
Documents) within 60 days after the date of the first closing. At each Closing,
the Company shall deliver to each Purchaser the Note and Warrant to be purchased
by such Purchaser against payment of the purchase price therefor by check or by
wire transfer to the Company's bank account.

          1.3  Certain Definitions.  When used herein, (A) "business day" shall
               -------------------                          ------------
mean any day on which the New York Stock Exchange and commercial banks in the
city of San Francisco are open for business, (B) an "affiliate" of a party shall
                                                     ---------
mean any person or entity controlling, controlled by or under common control
with that party and (C) "control" shall mean, with respect to an entity, the
                         -------
ability to direct the business, operations or management of such entity, whether
through an equity interest therein or otherwise.

2.        REPRESENTATIONS AND WARRANTIES OF EACH OF THE PURCHASERS.

          Each of the Purchasers hereby makes the following representations and
warranties to the Company and agrees with the Company that, as of the date of
this Agreement and as of the Closing Date:

          2.1  Authorization; Enforceability.  Such Purchaser, if an entity, is
               -----------------------------
duly and validly organized, validly existing and in good standing under the laws
of the jurisdiction of its incorporation or organization with full power and
authority to purchase the Notes and the Warrants and to execute and deliver this
Agreement.  This Agreement constitutes such Purchaser's valid and legally
binding obligation, enforceable in accordance with its terms, except as such
enforcement may be limited by (i) applicable bankruptcy, insolvency,
reorganization or other laws of general application relating to or affecting the
enforcement of creditors' rights generally and (ii) general principles of
equity.

          2.2  Accredited Investor; Investment Intent.  Such Purchaser is an
               --------------------------------------
accredited investor as that term is defined in Rule 501 of Regulation D, and is
acquiring the Securities solely for his or its own account for investment
purposes as a principal and not with a present view to the public resale or
distribution of all or any part thereof, except pursuant to sales that are
exempt from the registration requirements of the Securities Act or sales
registered under the Securities Act; provided, however that in making such
representation, such Purchaser does not agree to hold the Securities for any
minimum or specific term and reserves the right to sell, transfer or otherwise
dispose of the Securities at any time in accordance with the provisions of this
Agreement and with federal and state securities laws applicable to such sale,
transfer or disposition.

          2.3  Information.  The Company has provided such Purchaser with
               -----------
information regarding the business, operations and financial condition of the
Company, and has granted to such Purchaser the opportunity to ask questions of
and receive answers from representatives of the Company, its officers,
directors, employees and agents concerning the Company and

                                      -2-
<PAGE>

materials relating to the terms and conditions of the purchase and sale of the
Notes and Warrants hereunder.

          2.4  Limitations on Disposition.  Such Purchaser acknowledges that,
               --------------------------
except as provided in the Registration Rights Agreement, the Securities have not
been and are not being registered under the Securities Act and may not be
transferred or resold without registration under the Securities Act or unless
pursuant to an exemption therefrom.

          2.5  Legend.  Such Purchaser understands that the certificates
               ------
representing the Securities will bear at issuance a restrictive legend in
substantially the following form:

               "The securities represented by this certificate have not been
               registered under the Securities Act of 1933, as amended (the
               "Securities Act"), or the securities laws of any state, and may
                --------------
               not be offered or sold unless a registration statement under the
               Securities Act and applicable state securities laws shall have
               become effective with regard thereto, or an exemption from
               registration under the Securities Act and applicable state
               securities laws is available in connection with such offer or
               sale."

          Notwithstanding the foregoing, it is agreed that, as long as (A) the
resale of any of the Shares is registered pursuant to an effective registration
statement, (B) the Shares can be sold to the public pursuant to Rule 144 under
the Securities Act ("Rule 144") and a registered broker dealer provides to the
                     --------
Company a customary broker's Rule 144 letter, or (C) the Shares are eligible for
sale to the public, without limitation as to the amount of or manner in which
the Shares may be sold, under Rule 144(k) or any successor provision, the Shares
shall be issued without any legend or other restrictive language and, with
respect to Shares upon which such legend is stamped, the Company shall issue new
certificates without the legend to the holder upon request.

3.        REPRESENTATIONS AND WARRANTIES OF THE COMPANY.

          The Company hereby makes the following representations and warranties
to each of the Purchasers that, as of the date of this Agreement and as of the
initial Closing Date, except as disclosed in a document (the "Disclosure
                                                              ----------
Schedule") delivered to each of the Purchasers prior to the Closing:
--------

          3.1  Organization, Good Standing and Qualification.  Each of the
               ---------------------------------------------
Company and its subsidiaries is duly organized, validly existing and in good
standing under the laws of the jurisdiction of its incorporation or organization
and has all requisite corporate power and authority to carry on its business as
now conducted.

          3.2  Authorization; Consents.  The Company has the requisite corporate
               -----------------------
power and authority to enter into and perform its obligations under (i) this
Agreement, (ii) the Notes, (iii) the Warrants, (iv) the Security Agreement
attached as Exhibit E hereto, (v) the Registration Rights Agreement, (vi) all
            ---------
other agreements, documents, certificates or other instruments executed and
delivered by or on behalf of the Company at the Closing (the instruments
described

                                      -3-
<PAGE>

in (i) through (vi) being collectively referred to herein as the "Transaction
                                                                  -----------
Documents") and to issue and sell the Notes and Warrants to the Purchaser in
---------
accordance with the terms hereof. All corporate action on the part of the
Company by its officers, directors and stockholders necessary for the
authorization, execution and delivery of, and the performance by the Company of
its obligations under the Transaction Documents has been taken, and no further
consent or authorization of the Company, its Board of Directors, its
stockholders, any governmental agency or organization (other than as may be
required under the Securities Act and applicable state securities laws in
respect of the Registration Rights Agreement), or any other person or entity is
required (pursuant to any rule of the National Association of Securities
Dealers, Inc. (the "NASD") or otherwise).
                    ----

          3.3  Enforcement.  The Transaction Documents constitute valid and
               -----------
legally binding obligations of the Company, enforceable in accordance with their
respective terms, except as such enforcement may be limited by (i) applicable
bankruptcy, insolvency, reorganization or other laws of general application
relating to or affecting the enforcement of creditors' rights generally and (ii)
general principles of equity.

          3.4  Disclosure Documents; Agreements; Financial Statements; Other
               -------------------------------------------------------------
Information.  The Company has filed with the Commission: (i) the Company's
-----------
Annual Report on Form 10-K for the year ended December 31, 2000, (ii) all
Current Reports on Form 8-K required to be filed by the Company with the
Commission since December 31, 2000 (collectively, the "Disclosure Documents").
                                                       --------------------
The Company is not aware of any event occurring on or prior to the Closing
(other than the transactions effected hereby) that would require the filing of,
or with respect to which the Company intends to file, a Form 8-K after the
Closing.  Each Disclosure Document, as of the date of the filing thereof with
the Commission, conformed, and as of the Closing Date will conform, in all
material respects to the requirements of the Exchange Act, and the rules and
regulations thereunder and such Disclosure Document did not, as of the date of
such filing, and will not, as of the Closing Date, contain an untrue statement
of material fact or omit to state a material fact required to be stated therein
or necessary to make the statements therein, in light of the circumstances under
which they were made, not misleading; provided, however, that any information
set forth in any Disclosure Document that is a forward-looking statement as
defined in Rule 175(c) promulgated by the Commission under the Securities Act
shall not be deemed to contain an untrue statement of material fact as long as
such forward-looking statement was made with a reasonable basis and in good
faith.

          3.5  Capitalization.  The capitalization of the Company as of April
               --------------
30, 2001, including its authorized capital stock, the number of shares issued
and outstanding, the number of shares issuable and reserved for issuance
pursuant to the Company's stock option plans, the number of shares issuable and
reserved for issuance pursuant to securities exercisable for, or convertible
into or exchangeable for any shares of Common Stock is set forth in the
Disclosure Schedule.  All of such outstanding shares of capital stock have been,
or upon issuance will be, validly issued, fully paid and non-assessable.  No
shares of the capital stock of the Company are subject to preemptive rights or
any other similar rights of the stockholders of the Company or any liens or
encumbrances created by or through the Company.  Except as disclosed in the
Disclosure Schedule, or as contemplated herein, there are no outstanding
options, warrants, scrip, rights to

                                      -4-
<PAGE>

subscribe to, calls or commitments of any character whatsoever relating to, or
securities or rights convertible into or exercisable or exchangeable for, any
shares of capital stock of the Company or any of its subsidiaries, or
arrangements by which the Company or any of its subsidiaries is or may become
bound to issue additional shares of capital stock of the Company or any of its
subsidiaries.

          3.6  Valid Issuance.  The Warrants and the Shares are duly authorized
               --------------
and, when issued, sold and delivered in accordance with the terms of this
Agreement and the Company's Certificate of Incorporation, (i) will be duly and
validly issued, fully paid and nonassessable, free and clear of any taxes,
liens, claims, preemptive or similar rights or encumbrances imposed by or
through the Company, (ii) based in part upon the representations of each of the
Purchasers in this Agreement, will be issued, sold and delivered in compliance
with all applicable federal and state securities laws and (iii) upon exercise of
the Warrants, the Shares will be entitled to all of the rights, preferences and
privileges of the holders of the Common Stock of the Company.

          3.7  No Conflict with Other Instruments.  The execution,  delivery and
               ----------------------------------
performance of this Agreement and the other Transaction Documents, and
consummation of the transactions contemplated hereby and thereby will not result
in (a) a violation of any provision of the Certificate of Incorporation or by-
laws of the Company or its subsidiaries, (b) a violation of any Law (as defined
below) or any judgment, decree, order, regulation or rule of any court or other
Governmental Entity applicable to the Company, or (c) any violation of any
provision, instrument or contract to which the Company or any of its
subsidiaries is a party or by which any of their assets are subject, or an event
which results in the creation of any lien, charge or encumbrance upon any assets
of the Company or of any of its subsidiaries or the triggering of any preemptive
or anti-dilution rights or rights of first refusal or first offer on the part of
holders of the Company's securities.  "Law" shall mean any statute, ordinance,
                                       ---
code, rule, regulation or order enacted, adopted, promulgated, applied or
followed by any Governmental Entity.

          3.8  Solicitation.  Neither the Company nor any of its subsidiaries or
               ------------
affiliates, nor any person acting on its or their behalf, (i) has engaged in any
form of general solicitation or general advertising (within the meaning of
Regulation D) in connection with the offer or sale of the Shares or (ii) has,
directly or indirectly, made any offers or sales of any security or solicited
any offers to buy any security, under any circumstances that would require
registration of the Securities under the Securities Act.

          3.9  No Other Secured Debt.  The Company has no other secured debt,
               ---------------------
other than the Notes and capitalized lease obligations.

          3.10 No Material Undisclosed Liability. Except as described in the
               ----------------------------------
Disclosure Schedule and Disclosure Documents, to the Company's knowledge, there
is no material liability against the Company or any of its subsidiaries, or
against any officer or director of the Company or any such subsidiary in
connection with such person's employment therewith.  Neither the Company nor any
of its subsidiaries is a party to or subject to the provisions of, any order,
writ, injunction, judgment or decree of any court or government agency or
instrumentality which

                                      -5-
<PAGE>

could reasonably be expected to have a material adverse effect on the
consolidated business or financial condition of the Company and its subsidiaries
taken as a whole.

4.        COVENANTS OF THE COMPANY AND THE PURCHASERS.

          4.1  Provision of Information.  The Company shall provide each
               ------------------------
Purchaser, as long as the Purchaser holds any Warrants or Shares, with copies of
its annual reports on Form 10-K, quarterly reports on Form 10-Q, current reports
on Form 8-K and proxy statements and other materials sent to stockholders, in
each such case promptly after the filing thereof with the Commission.

5.        CONDITIONS TO CLOSING.

          5.1  Conditions to Each Purchaser's Obligations at Closing.  Each
               -----------------------------------------------------
Purchaser's obligations at the Closing, including without limitation his or its
obligation to purchase the Notes and Shares, are conditioned upon the
fulfillment (or waiver by such Purchaser) of each of the following events as of
the Closing Date:

               5.1.1  the representations and warranties of the Company set
forth in this Agreement shall be true and correct in all material respects as of
such date as if made on such date;

               5.1.2  the Company shall have complied with or performed in all
material respects all of the agreements, obligations and conditions set forth in
this Agreement that are required to be complied with or performed by the Company
on or before the Closing;

               5.1.3  the Company and each of the other Purchasers shall have
executed and delivered the applicable Transaction Documents;

               5.1.4  except for the effects of the Company's continued use of
cash in the ordinary course of business, there shall have been no material
adverse changes in the Company's consolidated business or financial condition
since the date of the Company's most recent financial statements delivered to
the Purchasers;

               5.1.5  there shall be no action or proceeding by or before any
federal, state, local or foreign  government or any court of  competent
jurisdiction, administrative agency or commission or other governmental
authority or instrumentality, domestic or foreign (a "Governmental Entity") or
                                                      -------------------
NASD, pending or threatened, challenging or seeking to restrain or prohibit the
purchase and sale of the Securities or any of the other transactions
contemplated by this Agreement or seeking to obtain damages from either party
hereto in connection with the purchase and sale of the Securities or any of the
other transactions contemplated by this Agreement; and

               5.1.6  there shall be no statute, rule, regulation, executive
order, decree, temporary restraining order, preliminary injunction, permanent
injunction or other order, enacted,

                                      -6-
<PAGE>

entered, promulgated, enforced or issued by any Governmental Entity or other
legal restraint or prohibition preventing the purchase and sale of the
Securities in effect.

          5.2  Conditions to Company's Obligations at Closing.  The Company's
               ----------------------------------------------
obligations at the Closing are conditioned upon the fulfillment (or waiver by
the Company) of each of the following events as of the Closing Date:

               5.2.1  the representations and warranties of each of the
Purchasers shall be true and correct in all material respects as of such date as
if made on such date;

               5.2.2  each of the Purchasers shall have complied with or
performed all of the agreements, obligations and conditions set forth in this
Agreement that are required to be complied with or performed by such Purchaser
on or before the Closing;

               5.2.3  there shall be no action or proceeding by or before any
Governmental Entity or NASD, pending or threatened, challenging or seeking to
restrain or prohibit the purchase and sale of the Securities or any of the other
transactions contemplated by this Agreement or seeking to obtain damages from
either party hereto in connection with the purchase and sale of the Securities
or any of the other transactions contemplated by this Agreement; and

               5.2.4  there shall be no statute, rule, regulation, executive
order, decree, temporary restraining order, preliminary injunction, permanent
injunction or other order, enacted, entered, promulgated, enforced or issued by
any Governmental Entity or other legal restraint or prohibition preventing the
purchase and sale of the Securities in effect.

6.        MISCELLANEOUS.

          6.1  Survival; Severability.  The representations, warranties and
               ----------------------
covenants made by the parties herein shall survive for twelve months after the
Closing notwithstanding any due diligence investigation made by or on behalf of
the party seeking to rely thereon.  In the event that any provision of this
Agreement becomes or is declared by a court of competent jurisdiction to be
illegal, unenforceable or void, this Agreement shall continue in full force and
effect without said provision; provided that in such case the parties shall
negotiate in good faith to replace such provision with a new provision  which is
not illegal, unenforceable or void, as long as such new provision does not
materially change the economic benefits of this Agreement to the parties.

          6.2  No Third Party Beneficiaries; No Assignment.  The terms and
               -------------------------------------------
conditions of this Agreement shall inure to the benefit of and be binding upon
the respective successors of the parties.  Nothing in this Agreement, express or
implied, is intended to confer upon any party other than the parties hereto or
their respective successors and permitted assignors any rights, remedies,
obligations or liabilities under or by reason of this Agreement, except as
expressly provided in this Agreement.  Neither the Company nor any of the
Purchasers may assign its rights and obligations under this Agreement, except
that a Purchaser may assign its rights and obligations hereunder in connection
with a permitted transfer of the entire interest of such Purchaser's Note and
Warrant as provided thereunder.

                                      -7-
<PAGE>

          6.3  No Reliance.  Each Purchaser acknowledges that such Purchaser (i)
               -----------
has such knowledge in business and financial matters as to be fully capable of
evaluating this Agreement, the other Transaction Documents and the transactions
contemplated hereby and thereby, (ii) is not relying on any advice or
representation of any other party in connection with entering into this
Agreement, the other Transaction Documents or such transactions (other than the
representations made in this Agreement or the other Transaction Documents),
(iii) has not received from any other party any assurance or guarantee as to the
merits (whether legal, regulatory, tax, financial or otherwise) of entering into
this Agreement or the other Transaction Documents or the performance of such
Purchaser's obligations hereunder and thereunder, and (iv) has consulted with
his or its own legal, regulatory, tax, business, investment, financial and
accounting advisors to the extent that such Purchaser has deemed necessary, and
has entered into this Agreement and the other Transaction Documents based on
such Purchaser's own independent judgment and on the advice of his or its
advisors as such Purchaser has deemed necessary, and not on any view (whether
written or oral) expressed by any other party.

          6.4  Governing Law; Jurisdiction.  This Agreement shall be governed by
               ---------------------------
and construed under the laws of the State of California without regard to the
conflict of laws provisions thereof.  Each party hereby irrevocably submits to
the exclusive jurisdiction of the state and federal courts sitting in San
Francisco or Alameda County in the State of California, for the adjudication of
any dispute hereunder or in connection herewith or with any transaction
contemplated hereby or discussed herein, and hereby irrevocably waives, and
agrees not to assert in any suit, action or proceeding, any claim that it is not
personally subject to the jurisdiction of any such court, that such suit, action
or proceeding is brought in an inconvenient forum or that the venue of such
suit, action or proceeding is improper.  Each party hereby irrevocably waives
personal service of process and consents to process being served in any such
suit, action or proceeding by mailing a copy thereof to such party at the
address in effect for notices to it under this Agreement and agrees that such
service shall constitute good and sufficient service of process and notice
thereof.  Nothing contained herein shall be deemed to limit in any way any right
to serve process in any manner permitted by law.

          6.5  Counterparts.  This Agreement may be executed in any number of
               ------------
counterparts, each of which shall be deemed an original, and all of which
together shall constitute one and the same instrument.

          6.6  Headings.  The headings used in this Agreement are used for
               --------
convenience only and are not to be considered in construing or interpreting this
Agreement.

          6.7  Notices.  Any notice, demand or request required or permitted to
               -------
be given by any party to any other party pursuant to the terms of this Agreement
shall be in writing and shall be deemed given (i) when delivered personally or
by verifiable facsimile transmission (with an original to follow) on or before
5:00 p.m., California time, on a business day or, if such day is not a business
day, on the next succeeding business day, (ii) on the next business day after
timely delivery to a nationally-recognized overnight courier and (iii) on the
third business day after deposit in the U.S. mail (certified or registered mail,
return receipt requested, postage prepaid), addressed to the Purchasers as shown
on Exhibit A and addressed to the Company as follows:
   ---------

                                      -8-
<PAGE>

     If to the Company:

          HealthCentral.com
          6005 Shellmound Street, Suite 250
          Emeryville, CA 94608
          Attn: Chief Executive Officer
          Fax: 510-250-2703

     with a copy to:

          Venture Law Group
          2775 Sand Hill Road
          Menlo Park, CA 94025
          Attn: Mark A. Medearis
          Fax: 650-233-8386

     6.8  Expenses.  The Company and each of the Purchasers shall pay their own
          --------
costs and expenses incurred in connection with the negotiation, execution,
delivery and performance of this Agreement.

     6.9  Entire Agreement; Amendments.  This Agreement and the other
          ----------------------------
Transaction Documents constitute the entire agreement between the parties with
regard to the subject matter hereof and thereof,  superseding all prior
agreements or understandings,  whether written or oral, between or among the
parties.  Except as expressly provided herein, neither this Agreement nor any
term hereof may be amended except pursuant to a written instrument executed by
the Company and the Purchasers holding all of the outstanding Notes and no
provision hereof may be waived other than by a written instrument signed by the
party against whom enforcement of any such waiver is sought.

     6.10 Finder's Fee.  Each party represents that it neither is nor will be
          ------------
obligated for any finder's fee or commission in connection with this
transaction.  Each Purchaser agrees to indemnify and to hold harmless the
Company and the other Purchasers from any liability for any commission or
compensation in the nature of a finder's fee (and the costs and expenses of
defending against such liability or asserted liability) for which such Purchaser
or any of its officers, employees, or representatives is responsible.  The
Company agrees to indemnify and hold harmless each of the Purchasers from any
liability for any commission or compensation in the nature of a finder's fee
(and the costs and expenses of defending against such liability or asserted
liability) for which the Company or any of its officers, employees or
representatives is responsible.

                                      -9-
<PAGE>

     IN WITNESS WHEREOF, this Agreement has been executed as of the date first
written above.

                                           HEALTHCENTRAL.COM

                                           By: /s/ C. Fred Toney
                                               ---------------------------------
                                           Name:  C. Fred Toney
                                                  ------------------------------
                                           Title: Chief Executive Officer
                                                  ------------------------------

             SIGNATURE PAGE TO NOTE AND WARRANT PURCHASE AGREEMENT
<PAGE>

     IN WITNESS WHEREOF, this Agreement has been executed as of the date first
written above.

                                 PURCHASERS:

                                    PORRIDGE, LLC

                                    By:    /s/ Arthur J. Samberg
                                           -------------------------------------

                                    Name:  Arthur J. Samberg
                                           -------------------------------------

                                    Title: Managing Partner
                                           -------------------------------------

                                    PAW OFFSHORE FUND, LTD.

                                    By:    /s/ John Ernenwein
                                           -------------------------------------

                                    Name:  John Ernenwein
                                           -------------------------------------

                                    Title: Chief Op. Officer of Inv. Advisor
                                           -------------------------------------

                                    PAW PARTNERS, LP.

                                    By:    /s/ John Ernenwein
                                           -------------------------------------

                                    Name:  John Ernenwein
                                           -------------------------------------

                                    Title: Chief Op. Officer of G.P.
                                           -------------------------------------

                                    HELZEL KIRSHMAN, L.P.

                                    By:    /s/ Lawrence B. Helzel
                                           -------------------------------------

                                    Name:  Lawrence B. Helzel
                                           -------------------------------------

                                    Title: General Partner
                                           -------------------------------------

            SIGNATURE PAGE TO NOTE AND WARRANT PURCHASE AGREEMENT
<PAGE>

                                    HORNTHAL LIVING TRUST

                                    By:    /s/ James Hornthal
                                           -------------------------------------

                                    Name:  James Hornthal
                                           -------------------------------------

                                    Title: Trustee
                                           -------------------------------------

                                    C. FRED TONEY

                                    By:    /s/ C. Fred Toney
                                           -------------------------------------

                                    Name:  C. Fred Toney
                                           -------------------------------------

                                    Title: _____________________________________

                                    BANK ONE TRUST COMPANY, N.A. AS TRUSTEE OF
                                    RONALD L. CHEZ IRA

                                    By:    /s/ Ruth A. Schaumberger
                                           -------------------------------------

                                    Name:  Ruth A. Schaumberger
                                           -------------------------------------

                                    Title: Vice President
                                           -------------------------------------

                                    LEO B. AND FLORENCE HELZEL LIVING TRUST

                                    By:    /s/ Leo B. Helzel
                                           -------------------------------------

                                    Name:  Leo B. Helzlel
                                           -------------------------------------

                                    Title: Trustee
                                           -------------------------------------

            SIGNATURE PAGE TO NOTE AND WARRANT PURCHASE AGREEMENT
<PAGE>

                                    HENRY F. BANNISTER

                                    By:    /s/ Henry F. Bannister
                                           ----------------------

                                    Name:      Henry F. Bannister
                                           ----------------------

                                    Title: ______________________

                                   THE LEONARD AND DENA OPPENHEIM REVOCABLE
                                   TRUST DATED 1/6/00

                                    By:    /s/ Leonard A. Oppenheim
                                           ------------------------

                                    Name:  Leonard A. Oppenheim
                                           ------------------------

                                    Title: Trustee
                                           ------------------------

                                    LARRY ZALK

                                    By:    /s/ Larry Zalk
                                           ------------------------

                                    Name:  Larry Zalk
                                           ------------------------

                                    Title: ________________________

                                    UBS PAINEWEBBER INC., NOT IN ITS CORPORATE
                                    CAPACITY BUT SOLELY AS CUSTODIAN FOR THE
                                    INDIVIDUAL RETIREMENT ACCOUNT OF CHARLES
                                    FREDERICK TONEY JR.

                                    By:    /s/ Stephen Massocca
                                           ------------------------

                                    Name:  Stephen Massocca
                                           ------------------------

                                    Title: President
                                           ------------------------

             SIGNATURE PAGE TO NOTE AND WARRANT PURCHASE AGREEMENT
<PAGE>

                                    THE KEVIN R.E. CASTNER SEPARATE PROPERTY
                                    REVOCABLE TRUST, DATED FEBRUARY 16, 2001

                                    By:    /s/ Kevin R.E. Castner
                                           ------------------------

                                    Name:  Kevin R.E. Castner
                                           ------------------------

                                    Title: Trustee
                                           ------------------------

             SIGNATURE PAGE TO NOTE AND WARRANT PURCHASE AGREEMENT
<PAGE>

                                   EXHIBIT A

                            SCHEDULE OF PURCHASERS

First Closing:  May 10, 2001

<TABLE>
<CAPTION>
                                                                                   Number of Shares Underlying
                                                                                   ---------------------------
            Name/Address                      Principal Amount of Note                        Warrant
            ------------                      ------------------------                        -------
<S>                                           <C>                                  <C>
Porridge, LLC                                        $1,000,000                              5,000,000
c/o Pequot Capital
500 Nyala Farm Rd.
Westport, CT 06880
Attn: Amy Jennings & Arthur J.
Samberg

PAW Offshore Fund, Ltd.                              $  550,000                              2,750,000
10 Glenville Street
Greenwich, CT 06831-3638
Attn: John Ernenwein & Peter Wright

PAW Partners, LP                                     $  450,000                              2,250,000
10 Glenville Street
Greenwich, CT 06831-3638
Attn: John Ernenwein & Peter Wright

Helzel Kirshman, L.P.                                $  100,000                                500,000
5550 Redwood Road, Suite 4
Oakland, CA 94619
Attn: Larry Helzel, G.P.

Hornthal Living Trust                                $  300,000                              1,500,000
2234 Beach Street
San Francisco, CA 94123
Attn: J. Hornthal Trustee

C. Fred Toney                                        $  100,000                                500,000
3383 Clay Street
San Francisco, CA  94118
Attn: C. Fred Toney

Subtotal of First Closing                            $2,500,000                             12,500,000
</TABLE>
<PAGE>

                               EXHIBIT A (con.)

                            SCHEDULE OF PURCHASERS

Other Closings:
---------------

<TABLE>
<CAPTION>
                                                                                   Number of Shares Underlying
                                                                                   ---------------------------
            Name/Address                      Principal Amount of Note                        Warrant
            ------------                      ------------------------                        -------
<S>                                           <C>                                  <C>
May 11, 2001
------------

Leo B. and Florence Helzel Living                    $  200,000                              1,000,000
Trust
5550 Redwood Road, Suite 4
Oakland, CA 94619
Attn: Leo Helzel

May 15, 2001
------------

Ronald L. Chez IRA                                    $  200,000                             1,000,000
605 West Madison
Tower #3 - Suite 311
Chicago, IL 60661
Attn: Ronald Chez

May 21, 2001
------------

Henry F. Bannister                                    $  100,000                               500,000
15 Sunrise Lane
Larkspur, CA 94939

May 25, 2001
------------

The Leonard and Dena Oppenheim                        $  200,000                             1,000,000
Revocable Trust Dated 1/6/00
138 Diablo View Drive
Orinda, CA 94563

May 29, 2001
------------

Larry Zalk                                            $  100,000                               500,000
51 Falmouth Street
Short Hills, NJ 07078
</TABLE>
<PAGE>

                               EXHIBIT A (con.)

                            SCHEDULE OF PURCHASERS

Other Closings:
---------------

<TABLE>
<CAPTION>
                                                                                   Number of Shares Underlying
                                                                                   ---------------------------
            Name/Address                      Principal Amount of Note                        Warrant
            ------------                      ------------------------                        -------
<S>                                           <C>                                  <C>
June 1, 2001
------------

UBS Painewebber                                       $  100,000                               500,000
as IRA custodian for Charles
Frederick Toney Jr.
c/o Pacific Growth Equities
4 Maritime Plaza
San Francisco, CA 94111
Attn: Brian Smith

The Kevin R.E. Castner Separate                       $  100,000                               500,000
Property Revocable Trust, dated
February 16, 2001
c/o Merril Lynch
600 California Street, 8th Floor
San Francisco, CA 94108

Subtotal of Other Closings                            $1,000,000                             5,000,000
Subtotal of First Closing                             $2,500,000                            12,500,000
Total of all Closings                                 $3,500,000                            17,500,000
</TABLE>
<PAGE>

                                   EXHIBIT B
                                   ---------

                                 FORM OF NOTE
                                 ------------

                            Filed as Exhibit 10.45
<PAGE>

                                   EXHIBIT C
                                   ---------

                                FORM OF WARRANT
                                ---------------

                            Filed as Exhibit 10.46
<PAGE>

                                   EXHIBIT D
                                   ---------

                         REGISTRATION RIGHTS AGREEMENT
                         -----------------------------

                            Filed as Exhibit 10.49
<PAGE>

                                   EXHIBIT E
                                   ---------

                              SECURITY AGREEMENT
                              ------------------

                             Filed as Exhibit 10.47

<PAGE>

                                   EXHIBIT F
                                   ---------

                              DISCLOSURE SCHEDULE
                              -------------------

3.5  Capitalization

Authorized Capital Stock:

Common Stock           100,000,000

Preferred                5,000,000

Issued and Outstanding:

Common Stock            50,661,038

Preferred Stock            480,000

Stock Option Plans:

                         Reserved for Issuance  Available for Grant  Outstanding

1998 Plan                3,000,000              1,268,559            1,148,776

1999 Plan                5,412,500              2,936,429            2,476,071

Directors' Plan            312,500                293,750               18,750

3.10 No Material Undisclosed Liability

On January 29, 2001, XOR, Inc. filed an action in Adams County, Colorado
District Court (Case No. 01 CV 108) against HealthCentral.com. The complaint
alleges breach of contract, unjust enrichment and promissory estoppel. The
complaint alleges monetary damages of approximately $1.3 million. The Company
has responded with an Answer and Counter Claim for breach of contract and has
retained the law firm of Moye, Giles, O'Keefe, Vermeire & Gorrell LLP, to
vigorously defend against this claim. The Company's financial statements have
capitalized $0.5 million related to XOR.

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