Document:

Lease Between Repligen Sweden AB (as successor-in-interest to Novozymes Biopharm

 Exhibit 10.18 
 

 
 Contract transfer of existing lease agreement no. 4301-7722-02 reg. the property situated in Hunnerup 1,
Lund 
 PARTIES 
  

			
	 Lanlord
	  	I-Parken in Lund AB (corporate id. no. 556263-8394)
		
	 Previous tenant
	  	Novozymes Biopharma AB (corporate id. no. 556727-0830)
		
	 Incoming tenant
	  	Repligen Sweden AB (org.nr 556869-0704)

 The parties agree as follows: 
 The incoming tenant, Repligen Sweden AB, takes over starting with 01-01-2012 the lease agreement no. 4301-7722-02 and thus the obligations and other terms and conditions imposed for the tenant under the
contract. 
 In connection with this transfer, the lease agreement is extended until 06-30-2017. The other terms and condition of the agreement
remain unchanged. 
 This transfer is subject to the guarantee commitments set out in Annex 1 of the “Parent Company” Repligen
Corporation. 
 The incoming tenant has taken over, read and understood the content of the lease agreement. 

The practical transfer of keys, any furniture and others is made between the old and new tenant. 

This Agreement has been prepared in three identical copies where each party receives a copy. An English translation of this transfer has been made by the
“Parent Company” acc. to Annex 2. 
  

					
	Malmö 2011-12-	 		 	Malmö 2011-12-
	Novozymes Biopharma AB	 		 	Repligen Sweden AB
			
	 /s/ Mikael Bundgaard-Nielsen
	 		 	 /s/ Walter Herlihy

			
	 Malmö 2011-12-
	 		 	
	 I-Parken i Lund AB
	 		 	
			
	 /s/ Johan Sjostedt
	 		 	

 

 
  

 Contract transfer of existing lease agreement no. 4301-7724-07 reg. the property situated in Hunnerup
1, Lund 
 PARTIES 
  

			
	 Lanlord
	  	I-Parken i Lund AB (corporate id. no. 556263-8394)
		
	 Previous tenant
	  	Novozymes Biopharma AB (corporate id. no. 556727-0830)
		
	 Incoming tenant
	  	Repligen Sweden AB (org.nr 556869-0704)

 The parties agree as follows: 
 The incoming tenant, Repligen Sweden AB, takes over starting with 01-01-2012 the lease agreement no. 4301-7724-07 and thus the obligations and other terms and conditions imposed for the tenant under the
contract. 
 In connection with this transfer, the lease agreement is extended until 06-30-2017. The other terms and condition of the agreement
remain unchanged. 
 This transfer is subject to the guarantee commitments set out in Annex 1 of the “Parent Company” Repligen
Corporation. 
 The incoming tenant has taken over, read and understood the content of the lease agreement. 

The practical transfer of keys, any furniture and others is made between the old and new tenant. 

This Agreement has been prepared in three identical copies where each party receives a copy. An English translation of this transfer has been made by the
“Parent Company” acc. to Annex 2. 
  

					
	Malmö 2011-12-	 		 	Malmö 2011-12-
	Novozymes Biopharma AB	 		 	Repligen Sweden AB
			
	 /s/ Mikael Bundgaard-Nielsen
	 		 	 /s/ Walter Herlihy

			
	 Malmö 2011-12-
	 		 	
	 I-Parken i Lund AB
	 		 	
			
	 /s/ Johan Sjostedt
	 		 	

 

 
  

 Contract transfer of existing lease agreement no. 4301-7734-01 reg. the property situated in Hunnerup
1, Lund 
 PARTIES 
  

			
	Lanlord	  	I-Parken i Lund AB (corporate id. no. 556263-8394)
		
	Previous tenant	  	Novozymes Biopharma AB (corporate id. no. 556727-0830)
		
	Incoming tenant	  	Repligen Sweden AB (org.nr 556869-0704)

 The parties agree as follows: 
 The incoming tenant, Repligen Sweden AB, takes over starting with 01-01-2012 the lease agreement no. 4301-7734-01 and thus the obligations and other terms and conditions imposed for the tenant under the
contract. 
 In connection with this transfer, the lease agreement is extended until 06-30-2017. The other terms and condition of the agreement
remain unchanged. 
 This transfer is subject to the guarantee commitments set out in Annex 1 of the “Parent Company” Repligen
Corporation. 
 The incoming tenant has taken over, read and understood the content of the lease agreement. 

The practical transfer of keys, any furniture and others is made between the old and new tenant. 

This Agreement has been prepared in three identical copies where each party receives a copy. An English translation of this transfer has been made by the
“Parent Company” acc. to Annex 2. 
  

					
	Malmö 2011-12-	 		 	Malmö 2011-12-
	Novozymes Biopharma AB	 		 	Repligen Sweden AB
			
	 /s/ Mikael Bundgaard-Nielsen
	 		 	 /s/ Walter Herlihy

			
	 Malmö 2011-12-
	 		 	
	 I-Parken i Lund AB
	 		 	
			
	 /s/ Johan Sjostedt
	 		 	

 

 
  

 Contract transfer of existing lease agreement no. 4301-7804-01 reg. the property situated in Hunnerup
1, Lund 
 PARTIES 
  

			
	Lanlord	  	I-Parken i Lund AB (corporate id. no. 556263-8394)
		
	Previous tenant	  	Novozymes Biopharma AB (corporate id. no. 556727-0830)
		
	Incoming tenant	  	Repligen Sweden AB (org.nr 556869-0704)

 The parties agree as follows: 
 The incoming tenant, Repligen Sweden AB, takes over starting with 01-01-2012 the lease agreement no. 4301-7804-01 and thus the obligations and other terms and conditions imposed for the tenant under the
contract. 
 In connection with this transfer, the lease agreement is extended until 06-30-2017. The other terms and condition of the agreement
remain unchanged. 
 This transfer is subject to the guarantee commitments set out in Annex 1 of the “Parent Company” Repligen
Corporation. 
 The incoming tenant has taken over, read and understood the content of the lease agreement. 

The practical transfer of keys, any furniture and others is made between the old and new tenant. 

This Agreement has been prepared in three identical copies where each party receives a copy. An English translation of this transfer has been made by the
“Parent Company” acc. to Annex 2. 
  

					
	Malmö 2011-12-	 		 	Malmö 2011-12-
	Novozymes Biopharma AB	 		 	Repligen Sweden AB
			
	 /s/ Mikael Bundgaard-Nielsen
	 		 	 /s/ Walter Herlihy

			
	 Malmö 2011-12-
	 		 	
	 I-Parken i Lund AB
	 		 	
			
	 /s/ Johan Sjostedt
	 		 	

					
	[logo]	  	LEASING AGREEMENT                	  	 Page 
 5
(4)
	THE SWEDISH PROPERTY FEDERATION	  	FOR NON-RESIDENTIAL PREMISES	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

					
	 [logo]
	 	LEASE CONTRACT	 	
			
	 Page 1 (2)
	 		 	
			
		 	FOR OFFICE SPACE	 	No. 33001 7722 02

 THE SWEDISH PROPERTY OWNERS’ ASSOCIATION 
 Today, the undersigned have made the following lease agreement:                     A check in the
box 
 means that the text following is applicable. 
  

																					
	Landlord	 	i-parken i Lund AB	 	 	 	Sign.            
	 	 		
	 	 	556263-8394	 	 	 	 
	Tenant	 		 	PIN/org. no.	 		 	Sign.                
	 	 		
	 	 	Novozymes Biopharma AB	 	556627-0830	 	 
	 Address of Office space

etc.
	 	  
 Municipality
	 	Property designation	 		 	
	 	  

Lund
	 	Hennerup                	 	 	 	 
	 	  
 Street address
	 		 		 	  

Stairs/house 
	 	  

Apartment no.
	 	
	 	 	  
 S.t Lars
v
	 	 	 	 	 	 	 	 
	
Condition and use of

the office space
	 	Unless otherwise indicated, the office space with associated facilities is being leased for use as:	 	Laboratory and office	 	 
	Size and extent of the office space	 	 Shop area
  
	 	 Office area in
  
	 		 		 	 Storage area in
  
	 	 Other area

 

	 	 	plan	 	m2
	 	 plan  
 1-
 4
	 	 m2

Approx.
 3015
	 	plan	 	m2
	 	plan	 	m2
	 	plan  	 	m2
                
	 	 		 		 	Appendix
	 	 	 ̈ The extent of the leased office space has been marked on the attached
drawing(s).	 	 	 	 
	 	 	 	 	 	 	 
	 	 	car access for loading and unloading  ̈	 	 ̈ place for sign	 	 place for
 display stand / machine  ̈
	 	 parking
 space(s) for
  ̈ car(s)
	 	 garage space(s)
 for
  ̈ car(s)
	 	 ̈ outbuilding
	
Furnishings,

etc.
	 	The office space is leased	 	In the event that the lease terminates, the Tenant, unless otherwise agreed, shall	 	Appendix

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	 Page 
 6
(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

																			
		 	 x  
	 	without special furnishings intended for the business	 	 ̈	 	with special furnishing intended for the business according to appendix	 		  	remove his property and restore the office space to an acceptable condition.	 	
				
	Lease term	 	 From
  

08/01/2005
	 		  	Through  
 11/30/2013

							
	 Termination period /
 Extension period
	 	 Termination of this contract
 must occur in writing at least
	 	9	 	    months	 		  	before the expiry of the agreed upon rental months period; otherwise the contract is extended by time.	 	 months
    36 each

				
	Rent	 	 SEK
  

5,600,000
                        per year, comprising   ̈  total
rent
	 		  	 x  rent excl. rent supplement marked
below

					
		  	  
 Index –

clause
	 	  
 x
	 	  
 Change of above-mentioned rent occurs in accordance
with attached index clause
	 	Appendix  

1

					
		  	 Heating and

hot water
	 	Necessary heating of the office space is arranged for by	 	Hot water is provided	 	
	  	 	  

 ̈      the Landlord        
                 ̈    the Tenant
	 	  

x    the whole
year     ̈  not at all     ̈

					
		  	Cost	 	x	 	Fuel / heat supplement is paid in accordance with attached clause    currently debited by 439000.00 / year	 	Appendix
				
		  	 Water and
 sewage
cost
	 	x      Water and sewage supplement is paid in accordance with attached
clause  currently debited by 215000.00 / year	 	Appendix
				
		  	  
 Cooling

Ventilation
	 	  
 Costs for operation of special cooling and
ventilation
	 	Appendix
	  	 	  
  ̈
	 	  
 facility is compensated in accordance with attached
clause
	 	
						
		  	Electricity	 	 ̈	 	included in the rent	 		 	x    the Tenant has his own subscription
						
		  	 Stairway

cleaning
	 	 ̈	 	included in the rent	 		 	x    to be arranged and paid by the Tenant
					
		  	 Packaging

and waste

collection
	 	 ̈	 	included in the rent	 	 ̈    to be arranged and paid by the Tenant
	  	 		 		 	          (however, it is incumbent on the Landlord to
provide waste bins and necessary

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	 Page 
 7
(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

													
		  	Snow removal
 and sanding
	  	x	 	included in the rent	 	 ̈	 	to be arranged and paid by the Tenant	  	
							
		  	Property tax	  	  

 ̈
	 	  
 included in the rent
	 	  

x
	 	  
 compensation for this tax is paid according to special
agreement
	  	 |  Appendix    

 
 2

		  	Unanticipated
 costs
	  	  
 If, after signing the agreement, unanticipated
increases in costs for the property arise due to
  
 a)      introduction or increase of outgoing tax specific to the property, fees, or charges which the Parliament, government, municipality, or authority may decide

 

b)      general refurbishment measures or the like on the property which not only
concern the office space and which the Landlord is required to perform as a result of a decision of the Parliament, government, municipality, or authority.
  

the Tenant shall, with effect from the entry of the costs, pay compensation to the Landlord for the accruing share at the office space of the total annual
costs for the property.
  
 The office space’s share is
14.9 percent. If the share has not been stated, it is made up of the Tenant’s rent (excl. any VAT) in relation to rents based on the property (excl. any VAT) at the time of the cost increase. For office space not leased, an
estimate of the market rent for the office space is thus made.
  
 By tax
according to a) above, VAT and property taxes are not intended, to the extent that compensation is paid for this [tax] in accordance with the agreement.
  

By unanticipated costs, such costs are meant which are not decided by the bodies specified under a) and b), at the time of the agreement’s entry into
force. The compensation is paid according to the rules below which relate to the payment of rent.

	 Value Added Tax (VAT)
	  	  
 x
The property owner / Landlord is liable for VAT for renting the office space. In addition to the rent, the Tenant shall compensate applicable VAT on each occasion.
  

 ̈ If the property owner / Landlord, after a decision of the Tax Agency, becomes liable for VAT for renting
the office space, in addition to the rent, the Tenant shall compensate applicable VAT on each occasion.
  
 The VAT that is paid with the rent is calculated on the specified rent amount as well as, in accordance with the rules for VAT on rent that are in force at the time, on, where applicable in accordance
with the lease contract, outgoing supplement and other compensation.

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	 Page 
 8
(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

 The Property Owner’s Association of Sweden form no. 12 A prepared in 1991 in consultation with
the Swedish Trade Federation / Swedish Hotel and Restaurant Association. Reprinting is prohibited. Lic. no.: 2160-3442-6750-20. Version no. 6.0. Licensed to: Realia Fastighets AB. 

 

									
		 		 		 	LEASE CONTRACT	 	
					
	Page 2 (2)	 		 		 		 	
					
		 		 		 	FOR OFFICE SPACE	 	No. 33001 7722 02

  

											
		  	A check in the box means that the text following is applicable.
	Rent payment	  	 The rent is paid in advance, without request, no later than the last working day before each

 
 x beginning of the
quarter         ̈ beginning of the month by deposit into
	  	 Postal giro no.
  

4888101-5
	 	 Bank giro no.
  

5480-6419

	  
 Interest,

payment reminder
	  	  
 In the event of late payment of rent, the Tenant shall
pay both interest according to the Interest Rate Act, and compensation for a written payment reminder according to the Act concerning compensation for collection charges, etc. Compensation for reminders is paid with the amount that applies on each
occasion, according to the regulation concerning compensation for collection charges, etc.

	  
 Maintenance, etc.
	  	  
  ̈ The Landlord
shall perform and pay for necessary maintenance of the office space and furnishings provided by him
	  	  
 However, the Tenant is responsible for
	  	  
 Appendix

	  	  
 x The Tenant shall
perform and pay for necessary maintenance of floor surfaces, walls, and ceilings, as well as furnishings provided by the Landlord
	  	  
 In addition, the Tenant’s maintenance obligation
includes:
	  	  
 Appendix

	  	  
  ̈ The
distribution of the maintenance responsibility appears in a separate appendix
	 		  	  
 Appendix

	  	  
 The Tenant is not entitled to a reduction of the rent
for obstruction or in usufruct during the period during which the Landlord has ordinary maintenance executed on the property or the leased premises. However, it is incumbent upon the Landlord to inform the Tenant in advance of the nature of the work
and its extent, as well as when and during what period of time the work is to be performed.
  
 In case the tenancy applies to shop premises / trade premises, with operations dependent upon the influx of customers, the

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	 Page 
 9
(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

									
		  	clause shall be valid only if a special agreement has been made in this regard.
		  	  
 It is incumbent upon

 
  
  ̈ the Landlord x the Tenant
	  	  
 at his own liability and expense to be responsible for
the measures that may be required by insurance companies or construction boards, environmental and health boards, fire authorities, or authorities, after the day of admission, for the office space’s utilization for the intended application. The
Tenant shall consult with the Landlord before the measures are taken.

	  	  
 If the Tenant makes modifications to the office space
without the necessary building permits, and as a result of this the Landlord is forced, according to the rules of PBL, to pay building fees or surcharges, the Tenant shall pay the corresponding amount to the Landlord.

	  
 Signs, awnings, windows, doors,
etc.
	  	  
 The Tenant is entitled, after consultation with the
Landlord, to erect signs customary to the business, under the precondition that the Landlord has no reasonable cause to refuse and that the Tenant has obtained the necessary permits from the concerned authorities. When vacating the office space, it
is incumbent upon the Tenant to restore the façade to an acceptable condition.
  
 In the event of more extensive property maintenance, such as façade renovation, it is incumbent upon the Tenant, at his own expense and without compensation, to disassemble and reassemble signs,
awnings, and antennae.
  
 The Landlord shall not erect machines and display
cases on the outer walls of the office space rented by the Tenant, without the Tenant’s consent, and [he] shall allow the Tenant the optional right to erect machines and display cases on the walls in question.

	  	  
  ̈ The
Landlord        x The Tenant        is responsible for damages to display windows, entrance doors, and
signs.

	  	  
 x The
Tenant is obligated to sign and maintain glass insurance on all display windows and entrance doors belonging to the office space.

	  
 Locks
	  	  
 It is incumbent upon

 
  ̈ the Landlord x the Tenant
	  	  
 to equip the office space with such locks and
anti-theft devices as are required for the Tenant’s business or enterprise insurance.

	  
 Force majeure
	  	  
 The Landlord exonerates himself from the obligation to
perform his part of the agreement and from the obligation to pay for damages if his commitment cannot be fulfilled at all, or only at abnormally high expense, due to war or riot, such work stoppage, blockade, fire, explosion, or intervention by
public authorities which the Landlord has no control over and could not foresee.

	  
 Security
	  	  
 The precondition for the applicability of this
agreement is that a security in the form of a
	  	  
 Appendix

	  	  
  ̈ bank
guarantee  ̈ security
 ̈                        be deposited no later than
	  	
	  
 Special
	  		  	  
 Appendix

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	 Page 
 10
(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

															
	  
 provisions
	  	see Appendix	  	3
	  
 Signature
	  	  
 This contract, which must not be entered into
without special consent, has been drafted in two identical copies, of which the parties each received one. The previous agreement between the parties concerning this office space ceases to be valid as of this agreement’s entry into
force.

	  	  
 Place/date

 
 [handwritten:] 05/05/31
	  	  
 Place/date

 
 Bagsværd 05/27/05

	  	  
 Landlord
	  	 Tenant
	  	[stamp:]	  	Arne W. Schmidt
	  	 i-parken i Lund AB 
	  	  
 Novozymes Biopharma AB
	  	Group Director
		  	[signature]	  	  
 [signature]
	  	
		  	  
  
  

Printed name
  
 Christopher Nilsson
	  	  
 [signature]
	  	  
 [stamp:]
	  	  
 Niels Münter

 
 Legal Counsel

 
 Novozymes A/S

 
 Krogshoejvej 36

 
 DK-2880 Bagsværd

	  
 Agreement to

vacate
	  	  
 Due to agreement made on this day, the contract
ceases to apply as of                                  until the day on which the Tenant
undertakes to vacate.

	  	  
 Place/date

 
	  	  
 Landlord
	  	  
 Tenant

	  
 Transfer
	  	  
 The lease contract above is transferred as
of

		  	  
 to

	  	  
 Incoming Tenant

 
	  		  	  
 Outgoing Tenant
	  	  
 PIN/org. no.

	  
 Above

transfer
 is
approved
	  	  
 Place/date
	  		  	  
 Landlord
	  		  	

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	 Page 
 11
(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

 The Property Owners’ Association of Sweden form no. 12 A prepared in 1991 in consultation with
the Swedish Trade Federation / Swedish Hotel and Restaurant Association. Reprinting is prohibited. Lic. no.: 2160-3442-6750-20. Version no. 6.0. Licensed to: Realia Fastighets AB. 

 

			
	[logo]	  	INDEX CLAUSE
	  
 Page 1 (2)
	  	
	  
 THE PROPERTY OWNERS’ ASSOCIATION

 
 Appendix no.
1                        
	  	  

                for office space

  

					
	Concerning	  	Lease contract no.	  	in the property
	  	33001 7722 02	  	Hennerup
	  
 Landlord
	  	  
 i-parken i Lund AB

556263-8394

	  
 Tenant
	  	  
 Novozymes Biopharma AB

556627-0830

	  
 Clause
	  	  
 Of the rent amount specified in the contract,
5,600,000            SEK, 100                    % or
            5,600,000             SEK shall constitute the base rent. During the lease period, an addition to the rent
amount shall be paid with respect to changes in the consumer price index (total index with 1980 as the base year), with a certain percent of the base rent, according to the reasons below.

 
 •      
For lease agreements that begin at any time during the period 01/01 – 06/30, the base rent is adjusted                      to the index
value for October of the previous year.

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	 Page 
 12
(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

					
		  	  

•      For lease agreements that begin at any time during the period 07/01
– 12/31, the base rent is instead                      adjusted to the index value for October of the same period.

 

•      The index value for October, to which the base rent is considered to
be adjusted in accordance with                      the above, constitutes the base number unless otherwise agreed upon as follows by indicating the
year.                      Otherwise agreed upon base number, namely the index value for October 2004.

 
 If the index value should rise in relation to the base number in any subsequent
October, an addition shall be paid with the percentage by which the index value is changed in relation to the base number. In the continuation, the addition shall be paid in relation to the index changes, whereby the change in rent is calculated on
the basis of the percent change between the base number and the index number for the respective October.
  
 Outgoing rent, however, shall never be set lower than the rent amount specified in the contract. The change in rent always occurs as of January 1 after the October index occasions the
recalculation.
  
 The instructions on page 2 are applicable to the
agreement.

	  
 Signature
	  	  
 Place/date
 [handwritten:] 05/05/31
	  	  
 Place/date
 [handwritten:] Bagsværd

	  	  
 Landlord

i-parken i Lund AB
	  	  
 Tenant
 Novozymes Biopharma AB
 [signature]

	  	  	  
 Printed name [stamp:] Arne W. Schmidt

                         
           Group Director

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	 Page 
 13
(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

									
		  	[signature]	  	 Tenant
 [signature]

 
	  		  	
		  	  
 Christopher Nilsson
	  	  
 Printed name 
	  	  
 [stamp:]
	  	  
 Niels Münter

 
 Legal Counsel

 
 Novozymes A/S

 
 Krogshoejvej 36

 
 DK-2880 Bagsværd

 The Landlord’s own entry on base number: 281 

 
   

 
 The Swedish Property Owners’ Association
form no. SE, prepared in 1999 in consultation with the Swedish Trade Federation and the Swedish Hotel and Restaurant Association. The copy of the instructions was revised in May 2002. Reprinting is prohibited. 

Lic. no.: 2160-3442-6750-20. Version no. 6.0. Licensed to: Realia Fastighets AB. 

Page 2 (2) 

Instructions for the Index Clause for Office Space 
 The Base Rent 
 Whether the whole or some part of the rent amount
specified in this agreement should constitute the base rent is a matter for negotiation, and may otherwise depend on the lease terms (such as, for example, the rent’s size in SEK/m2 and 

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	 Page
 14
(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

 
the year, as well as the other obligations that are incumbent upon the Tenant, etc.). 

The Base Number 
 The index number for
October, to which the base rent is considered to be adjusted, makes up the base number unless otherwise indicated by indicating the year (see the provisions on page 1). 
 A comparison of indices occurs as soon as the year’s October index is published. In recent years, the October index has been published in mid-November. 

Calculation of the rent supplement 
  

	 	1)	Calculate the difference between the current October index and the base number. 

 

	 	2)	If the difference is positive, the calculated difference is divided by the base number. 

 

	 	3)	The size of the rent supplement is calculated by this quotient, multiplied by the base rent. 

 Example 
 Calculation of rent supplement for the year 2002 

The base rent is assumed to be 100,000 SEK/year and is adjusted to the consumer price index (CPI) for October 1999, which is 259.7 (Base number). The
October index for the year 2001 is 269.1. 
  

	 	1.	Calculate the difference between the index number 269.1 and 259.7. The difference is positive and adds up to 9.4. 

 

	 	2.	Divide 9.4 by 259.7 and multiply the quotient (without rounding) by the base rent 100,000 SEK. The result is 3,619.56 SEK and constitutes the rent supplement for the
year 2002 according to the clause. 

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	 Page 
 15
(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

 Alternative A: If the CPI for October 2001 should instead end up being lower than the year before,
e.g. 262.0 (October index for year 2000 was 262.6). 
 The difference between the assumed 262.0 and the base number 259.7 would still have
been positive and added up to 2.3. The quotient between 2.3 and the base number 259.7, multiplied by the base rent 100,000 SEK would have resulted in a rent supplement of 885.63 SEK. The total rent, however, would have been lower than for the year
2001. 
 Alternative B: If the CPI for October 2001 should instead end up being lower than the base number 259.7, e.g. 259.5. 

The difference between 259.5 and the base number 259.7 would have then been negative. No rent supplement should then be paid. The rent amount specified
in the agreement should apply. 
 [initials] 
  

			
	[logo]	 	 INDEX CLAUSE

		
	 Page 1 (2)
	 	
	THE PROPERTY OWNERS’ ASSOCIATION	 	for office space
		
	Appendix no.	 	

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	 Page 
 16
(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

 2 

					
	Concerning	  	Lease contract no.	  	for the property
	  	  
 33001 7722 02
	  	Hennerup
		
	Landlord	  	 i-parken i Lund AB
  

556263-8394

	Tenant	  	  
 Novozymes Biopharma AB,
556627-0830

		
	Clause	  	 The applicable option is marked with a cross in the box and filled in with the required information.

 
 To the extent that the portions of the property that consist of the office space
should be/are liable to property taxes, the Tenant shall pay the Landlord compensation for this along with the rent, according to the marked option.
  

x  In addition to the rent amount specified in the contract, the Tenant shall annually pay for
compensation for his share of outgoing property taxes for the office space on each occasion. The Tenant’s share shall be considered to be 14.9 percent.
  

According to the rules that apply at the time of the signing of the contract, the compensation constitutes 171,605 SEK per year at the start of the lease
period.
  

 ̈  Compensation for the share of the property taxes accruing at the office space is included in
the rent amount specified in the agreement and constitutes                      SEK at the time of the signing of the agreement.

 
 The office space’s share of the property taxes for the office space shall be
considered to be      percent. The Tenant shall pay compensation for his share of changes that occurred (regardless of the reason for them) in the property taxes for the office space, after the signing of the agreement, to the
extent that the taxes exceed the compensation for the property taxes that is included in the rent.

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	 Page 
 17
(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

									
		 	 If the property taxes should happen to decrease/cease, with the result that the Tenant’s share of the compensation
is less than the compensation that is included in the rent specified in the agreement, in accordance with the above, however, the rent shall at least amount to the original amount. Other clauses (e.g. index) found in the agreement thus entail that
the total rent amount that the Tenant pays is/may be higher than the rent sum specified in the agreement.
  
 The Tenant’s share specified above, which shall be unaltered during the rental period, has been calculated according to the following:

		 	  

		
		 	  

		
		 	  

		
		 	The instructions on page 2 are applicable to the agreement.
				
	Signature	 	 Place/date
  

[handwritten:] 05/05/31
	 		  	 Place/date
  

[handwritten:] Bagsværd 05/27/05

	 	  
 Landlord

 
 i-parken i Lund AB

 
 [signature]
	 		  	  
 Tenant

 
 [signature]    [signature]

 
	  	
					
		 	Christopher Nilsson	 		  	 Printed name 
 [stamp:] Arne
W. Schmidt 
 Group Director
  

Novoyzmes A-S
	  	 [stamp:] Niels Münter
 Legal Counsel
  

Krogshoejvej 36
 DK-2880
Bagsværd

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	 Page 
 18
(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

 Bagsværd 

 
 The Swedish Property Owners’ Association
form no. 78, prepared in 1995. Section 2 of Instructions, revised in 1997. 
 Reprinting is prohibited. 

Lic. no.: 2160-3442-6750-20. Version no. 6.0. Licensed to: Realia Fastighets AB. 
 INSTRUCTIONS 
 Page 2(2) 

1. 
 The
clause was formulated in June 1995, i.e. before the time (usually January 1, 1996) from which the property taxes apply for the office space. The clause therefore has a wording that means that this can be introduced into the agreement that is
signed before the taxes are paid, as well as in the agreement that is signed when the taxes are actually paid. 
 2.

 The compensation shall compensate for increased administrative costs, regardless of who is actually liable for tax.
Property owners / Landlords are liable for tax. If partnerships are property owners / Landlords, according to previous rules, shareholders are liable for tax. The rent supplement would of course yet be paid to the Landlord. After January 1,
1997, however, partnerships, as owners, are liable for property taxes. 
 3. 

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	 Page 
 19
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		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

 According to § 19 of the Rent Act, the rent – with some
exceptions – shall be the amount determined in the rent agreement. If the lease period is determined and for at least three years, moreover, a reservation applies that the rent shall be paid by the amount that is determined according to
“another basis for calculation,” e.g. adjustment of the index. This also means that the lease term must be determined at least three years before the Landlord shall be able to charge compensation for property taxes, with an amount that can
vary according to the change in the tax. Furthermore, the basis for calculation must be specified in the agreement. The clause therefore assumes that the parties will indicate for how large a share of the tax the Tenant must pay compensation.

 According to the rules that are applicable at the time of this clause’s preparation, the tax constitutes
a certain percent of the assessment value for the office space (both land and buildings). The declaration is reported in the tax information. The Tenant’s share of the tax for the office space can be determined as the relationship between the
area that the Tenant rents and the rentable area of the property, or as the relationship between the Tenant’s rent and the total rents on the property. 
 What rate of calculation the parties select becomes a matter for negotiation. Other bases for calculation can also be used. For the sake of simplicity, however, the Tenant’s share should be unchanged
during the lease term and, thus, independent of, for example, how the taxes can continue to be calculated, and any changes in the position of the rent. 
 It is appropriate, therefore, to indicate at the intended place how the office space’s share has been calculated. If the information relating to this should happen not to be filled in, this shall not
mean, however, that the agreement becomes invalid. On a property, various buildings can be found with various values and various types of assessable units (single-family home, apartment building, industrial facility, and special unit). The tax
– for which the Tenant shall pay compensation – shall only relate to the building where the office space is located. A building usually refers to each structural body. Required information can be retrieved from the notification of the

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	 Page 
 20
(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

 
decision about general property assessment which the Tax Agency sends to the property owner. The property owner who has problems calculating the Tenant’s share should contact his property
owner’s association for assistance. 
 Fill in the Tenant’s share! 

4. 
 The
clause contains two options. In the first, compensation is paid for tax as a rent supplement “alongside” the rent amount specified in the agreement. The tax and the rent supplement disappear automatically. The other option assumes that the
parties are in agreement about a certain rent in which, for instance, compensation for the applicable tax is included. If the tax should happen to be raised, regardless of the reason (e.g. high tax rate, increased tax assessment value, etc.) the
Tenant shall nevertheless pay compensation for the increased cost. If the tax should happen to disappear, the rent returns to the original amount, i.e. the agreed upon rent (which includes compensation for the initially applicable tax which ceased).
Naturally the Tenant shall still pay other rent supplements that occur, such as for changes in the index, changes in fuel costs, etc. 
 5. 
 To the extent that the Tenant shall pay a rent supplement for property
taxes, the rent supplement should be reported separately on the rent specification. 
 6. 

Mark with cross the option which you have selected. In the option selected, the Tenant’s share and the current amount are indicated.
Furthermore, indicate how the Tenant’s share is calculated. 

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	 Page 
 21
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		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

 [initials] 
 [logo] 
  

			
	Page 1 (1)	  	
	 THE PROPERTY OWNERS’ ASSOCIATION

Appendix no. 3
	  	

 The undersigned have today made an agreement concerning the following supplement to lease contract no. 33001 7722
02 
  

			
	Landlord	  	i-parken i Lund AB, 556263-8394
		
	Tenant	  	Novozymes Biopharma AB, 556627-0830
		
	Property	  	Hennerup
		
	Supplement	  	 The Tenant shall take over and pay for service of existing and new ventilation and water and sewage plants. Realia (the Landlord) shall
provide consumable materials on an ongoing basis.
  
 This agreement replaces
lease contract 33001 7722 01, 33001 7758 01 and 33001 7759 01.

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	 Page 
 22
(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

							
		  		  	
	Signature	  	 Place/date

[handwritten:] 05/05/31
	  	 Place/date
 [handwritten:]
Bagsværd 05/27/05

	  	  
 Landlord

 
 i-parken i Lund AB
 [signature]
	  	  
 Tenant

 
 [signature]    [signature]

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	 Page 
 23
(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

											
		  	Christopher Nilsson	  	 Printed name
	  	 [stamp:]
	  	 Niels Münter 

		  		  	 [stamp:]
	  	 Arne W. Schmidt
	  		  	 Legal Counsel

		  		  		  	 Group Director
	  		  	
		  		  	 Novoyzmes A-S
	  		  	
		  		  		  		  		  	 Krogshoejvej 36

DK-2880

		  		  	 Bagsværd
	  		  	

 (ENGLISH TRANSLATION) 

 

					
	LEASE CONTRACT	  	Page 1 (2)	  	
		  	FOR OFFICE SPACE	  	No. 33001 7722 02
	THE SWEDISH PROPERTY OWNERS’ ASSOCIATION	  	
	Today, the undersigned have made the following lease agreement:	  	A check in the box means that the
	text following is applicable.	  	

  

																																					
	Landlord	 	i-parken i Lund AB	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	Sign.
	 	 	 	 	556263-8394	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	Tenant	 		 		 		 		 		 		 		 		 		 		 	PIN/org. no.	 	Sign.	 		 	 
	 	 	 	 	Novozymes Biopharma AB	 	 	 	 	 	 	 	 	 	 	 	 	 	556627-0830
	Address of Office space etc.	 	Municipality	 		 		 		 		 		 	Property designation	 		 		 	 
	 	Lund	 	 	 	 	 	 	 	 	 	 	 	Hennerup	 	 	 	 	 	 
	 	Street address	 		 		 		 		 		 		 		 		 	Stairs/house	 		 	Apartment no.
	 	 S.t Lars v
  
	 		 		 		 		 		 		 		 		 		 		 		 		 		 	 
	Condition and use of the office
space	 	Unless otherwise indicated, the office space	 	Laboratory and office	 	 	 	 	 	 	 	 	 	 
	 	with associated facilities is being leased for use as:	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 Size and extent of
the office space
	 	Shop area	 	Office area in	 		 		 		 		 	 Storage area in
	 	Other area	 		 		 	 
	 	plan	 	m2	 	plan	 	m2	 	plan	 	 m2
	 	plan	 	m2	 		 	plan	 	m2	 		 		 	 
	 		 		 	1-4	 	Approx.	 		 		 		 		 		 		 		 		 		 		 	 
	 		 		 		 	3015	 		 		 		 		 		 		 		 		 		 		 	 
	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	Appendix
	 	 ̈ The extent of the leased office space has been marked on the attached
drawing(s).	 	 	 	 
	 	 car access for loading and unloading
  ̈
	 	 ̈ place for sign	 	 place for display stand / machine

 ̈
	 		 	 parking
 space(s)
for
	 	 garage space(s)

for
	 		 		 	 
	 	 	 	 	 	 	 	 	 	 ̈    car(s)	 	 ̈    car(s)	 	 	 	 ̈ 
outbuilding
	Furnishings, etc.	 	The office space is leased	 		 		 		 		 		 		 	In the event that the lease terminates, the Tenant, unless otherwise agreed, shall remove his property and restore the office space to an acceptable
condition.	 	Appendix
	 		 		 		 		 		 		 		 		 		 	 	 
	 	 x   without special furnishings intended
for the business
	 	  ̈   with special furnishings intended for
the business according to appendix
	 		 	 	 
	 	 	 		 	 	 
	 	 	 		 	 	 
	Lease term	 	From	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	Through	 	 	 	 	 	 	 	 
	 	 	 	 	08/01/2005	 	 	 	 	 	 	 	 	 	 	 	 	 	11/30/2013	 	 	 	 	 	 	 	 
	Termination period / Extension period	 	Termination of this contract	 		 		 		 		 		 	before the expiry of the agreed upon rental	 		 	months
	 	must occur in writing at least	 	9                    
        months	 	 period; otherwise the contract is extended
by                            36
	 	each time.
	Rent	 	SEK	 		 		 		 		 		 		 		 		 		 		 		 		 		 		 	 
	 	 	 	 	5,600,000	 	 	 	per year, comprising         ̈ total rent                        x
rent excl. rent supplement marked below
	 	 	Index –	 		 		 		 		 		 		 		 		 		 		 		 		 		 		 		 	Appendix

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	 Page 
 24
(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

																																					
		 	clause	 	x Change of above-mentioned rent occurs in accordance with attached index clause	 		 		 		 	1
		 	Heating and hot water	 	Necessary heating of the office space is arranged for by	 		 	Hot water is provided	 		 		 		 		 	
		 	 	 ̈ the
Landlord                         ̈ the Tenant	 		 	x the whole year     ̈ not at
all     ̈	 		 		 		 	
		 	Cost	 		 		 		 		 		 		 		 		 		 		 	Appendix
		 		 	x Fuel / heat supplement is paid in accordance with attached clause      currently
debited by 439000.00 / year	 	
		 	Water and sewage cost	 		 		 		 		 		 		 		 		 		 		 	Appendix
		 	 	x Water and sewage supplement is paid in accordance with attached clause      currently
debited by 215000.00 / year	 	
		 	Cooling Ventilation	 	Costs for operation of special cooling and ventilation	 		 		 	Appendix
		 	 	 ̈ facility is compensated in accordance with attached clause	 	
		 	Electricity	 		 		 		 		 		 	
		 		 	 ̈ included in the rent 	 	x the Tenant has his own subscription	 	
		 	Stairway cleaning	 		 		 		 		 		 	
		 	 	 ̈ included in the rent 	 	x to be arranged and paid by the Tenant	 	
		 	Packaging and waste collection	 		 		 		 		 		 		 		 		 		 		 	
		 	 	 ̈included in the rent	 	 ̈ to be arranged and paid by the Tenant	 		 		 	
		 	 		 		 		 	    (however, it is incumbent on the Landlord to provide waste bins and necessary	 	
		 	Snow removal and sanding	 		 		 		 		 		 		 		 		 		 		 	
		 	 	x included in the rent	 	 ̈ to be arranged and paid by the Tenant	 		 		 	
		 	Property tax	 		 		 		 		 		 		 		 		 		 		 	Appendix
		 	 	 ̈ included in the rent	 	x compensation for this tax is paid according to special agreement	 	2
		 	Unanticipated costs	 	If, after signing the agreement, unanticipated increases in costs for the property arise due to	 	
		 	 		 	  

c)          introduction or increase of outgoing tax specific
to the property, fees, or charges which the Parliament, government, municipality, or authority may decide
  

d)         general refurbishment measures or the like on the
property which not only concern the office space and which the Landlord is required to perform as a result of a decision of the Parliament, government, municipality, or authority.

		 	 	  
 the Tenant shall, with effect from the entry of the
costs, pay compensation to the Landlord for the accruing share at the office space of the total annual costs for the property.
  

The office space’s share is 14.9 percent. If the share has not been stated, it is made up of the Tenant’s rent (excl. any VAT) in
relation to rents based on the property (excl. any VAT) at the time of the cost increase. For office space not leased, an estimate of the market rent for the office space is thus made.

 
 By tax according to a) above, VAT and property taxes are not intended, to the extent
that compensation is paid for this [tax] in accordance with the agreement.
  

By unanticipated costs, such costs are meant which are not decided by the bodies specified under a) and b), at the time of the agreement’s entry into
force. The compensation is paid according to the rules below which relate to the payment of rent.

	 Value Added Tax (VAT)
	 	 x The property owner / Landlord is liable for VAT for renting the office
space. In addition to the rent, the Tenant shall compensate applicable VAT on each occasion.
  
  ̈ If the property owner / Landlord, after a decision of the Tax Agency, becomes liable for VAT for renting the office space, in addition to the rent, the
Tenant shall compensate applicable VAT on each occasion.
  
 The VAT that is
paid with the rent is calculated on the specified rent amount as well as, in accordance with the rules for VAT on rent that are in force at the time, on, where applicable in accordance with the lease contract, outgoing supplement and other
compensation.

 The Property Owners’ Association of Sweden form no. 12 A prepared in 1991 in consultation with
the Swedish Trade Federation / Swedish Hotel and Restaurant Association. Reprinting is prohibited. Lic. no.: 2160-3442-6750-20. Version no. 6.0. Licensed to: Realia Fastighets AB. 

 

					
		  	LEASE CONTRACT	  	

 Page 2 (2) 

					
		  	FOR OFFICE SPACE	  	No. 33001

 7722 02 
 A check in the box means that the text following is applicable. 
  

																					
	Rent payment	  	 The rent is paid in advance, without request, no later than the last working day before each

x beginning of the quarter  ̈ beginning of the
month            by deposit into
	 	Postal giro no.
 4888101-5
	    	Bank giro no.
 5480-6419

	 Interest,
 payment
reminder
	  	In the event of late payment of rent, the Tenant shall pay both interest according to the Interest Rate Act, and compensation for a written payment reminder according
to the Act concerning compensation for collection charges, etc. Compensation for reminders is paid with the amount that applies on each occasion, according to the regulation concerning compensation for collection charges,
etc.

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	 Page 
 25
(4)
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

																					
	Maintenance, etc.	  	 ̈ The Landlord shall perform and pay for necessary maintenance of the office space and furnishings provided by
him	  	However, the Tenant is responsible for	  	Appendix
				
		  	x The Tenant shall perform and pay for necessary maintenance of floor surfaces, walls, and ceilings, as well as
furnishings provided by the Landlord	  	In addition, the Tenant’s maintenance obligation includes:	  	Appendix
			
		  	 ̈ The distribution of the maintenance responsibility appears in a separate appendix	  	Appendix
		
		  	 The Tenant is not entitled to a reduction of the rent for obstruction or in usufruct during the period during which the
Landlord has ordinary maintenance executed on the property or the leased premises. However, it is incumbent upon the Landlord to inform the Tenant in advance of the nature of the work and its extent, as well as when and during what period of time
the work is to be performed.
  
 In case the tenancy applies to shop
premises / trade premises, with operations dependent upon the influx of customers, the clause shall be valid only if a special agreement has been made in this regard.

		  	 It is incumbent upon
  

 
  ̈ the Landlord x the Tenant
	  	at his own liability and expense to be responsible for the measures that may be required by insurance companies or construction boards, environmental and health boards,
fire authorities, or authorities, after the day of admission, for the office space’s utilization for the intended application. The Tenant shall consult with the Landlord before the measures are taken.
		
		  	If the Tenant makes modifications to the office space without the necessary building permits, and as a result of this the Landlord is forced, according to the rules of
PBL, to pay building fees or surcharges, the Tenant shall pay the corresponding amount to the Landlord.
		
	Signs, awnings, windows, doors, etc.	  	 The Tenant is entitled, after consultation with the Landlord, to erect signs customary to the business, under the
precondition that the Landlord has no reasonable cause to refuse and that the Tenant has obtained the necessary permits from the concerned authorities. When vacating the office space, it is incumbent upon the Tenant to restore the façade to
an acceptable condition.
  
 In the event of more extensive property
maintenance, such as façade renovation, it is incumbent upon the Tenant, at his own expense and without compensation, to disassemble and reassemble signs, awnings, and antennae.

 
 The Landlord shall not erect machines and display cases on the outer walls of the
office space rented by the Tenant, without the Tenant’s consent, and [he] shall allow the Tenant the optional right to erect machines and display cases on the walls in question.

		
		  	 ̈ The Landlord         x The
Tenant         is responsible for damages to display windows, entrance doors, and signs.
		
		  	x The Tenant is obligated to sign and maintain glass insurance on all display windows and entrance doors belonging to
the office space.
			
	Locks	  	 It is incumbent upon
  

 ̈ the Landlord x the Tenant
	  	to equip the office space with such locks and anti-theft devices as are required for the Tenant’s business or enterprise insurance.
		
	Force majeure	  	The Landlord exonerates himself from the obligation to perform his part of the agreement and from the obligation to pay for damages if his commitment cannot be
fulfilled at all, or only at abnormally high expense, due to war or riot, such work stoppage, blockade, fire, explosion, or intervention by public authorities which the Landlord has no control over and could not foresee.
				
	Security	  	 The precondition for the applicability of this agreement is that a security in the form of a

 
	 		 	Appendix

		  	 ̈bank guarantee  ̈ security
 ̈                     be deposited no later than	 		 	
				
	 Special

provisions
	  	see Appendix	 		 	Appendix 3

		
	Signature	  	This contract, which must not be entered into without special consent, has been drafted in two identical copies, of which the parties each received one. The previous
agreement between the parties concerning this office space ceases to be valid as of this agreement’s entry into force.
	  		  		  		  		  		 	
		  	 Place/date

[handwritten:] 05/05/31
	  	 Place/date
 Bagsværd
05/27/05
	  		 	
		  	 Landlord
 i-parken
i Lund AB
	  	 Tenant

Novozymes Biopharma AB
	  		 	[stamp:]	 	Arne W. Schmidt
 Group
Director

		  	 [signature]
  

 
  
 Printed
name
 Christopher Nilsson
	  		  		  	 [signature]

[signature]
	  		 	  
 [stamp:]
	 	  
 Niels Münter

Legal Counsel
 Novozymes
A/S
 Krogshoejvej 36

DK-2880 Bagsværd

		  	  		  		  		  		 	 	
				
	 Agreement to

vacate
	  	Due to agreement made on this day, the contract ceases to apply as of	 		 	until the day on which the Tenant undertakes to vacate.
	  	  
 Place/date
	  	  
 Landlord
	  		 		 	  
 Tenant
	  		  		  	
		
	Transfer	  	The lease contract above is transferred as of

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	 Page 
 26
(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

																					
		  	to
				
		  	Incoming Tenant	  	Outgoing Tenant 	  	PIN/org. no.
			
	Above transfer is approved	  	Place/date	  	Landlord

 The Property Owners’ Association of Sweden form no. 12 A prepared in 1991 in consultation with the Swedish Trade
Federation / Swedish Hotel and Restaurant Association. Reprinting is prohibited. Lic. no.: 2160-3442-6750-20. Version no. 6.0. Licensed to: Realia Fastighets AB. 
  

					
	[logo]	  	INDEX CLAUSE	  	
	 Page 1 (2)
	  		  	
	THE PROPERTY OWNERS’ ASSOCIATION	  	for office space	  	Appendix
	no. 1	  		  	

  

					
	Concerning	  	Lease contract no.	  	in the property
	  	33001 7722 02	  	Hennerup
		
	Landlord	  	 i-parken i Lund AB
 556263-8394

		
	Tenant	  	 Novozymes Biopharma AB
 556627-0830

		
	Clause	  	 Of the rent amount specified in the contract,
5,600,000             SEK, 100                    % or      5,600,000
             SEK shall constitute the base rent. During the lease period, an addition to the rent amount shall be paid with respect to changes in the consumer price index (total index
with 1980 as the base year), with a certain percent of the base rent, according to the reasons below.
  

•      For lease agreements that begin at any time during the period
01/01 – 06/30, the base rent is adjusted to the index value for October of the previous year.
  

•      For lease agreements that begin at any time during the period 07/01
– 12/31, the base rent is instead adjusted to the index value for October of the same period.
  

•      The index value for October, to which the base rent is considered to
be adjusted in accordance with the above, constitutes the base number unless otherwise agreed upon as follows by indicating the year. Otherwise agreed upon base number, namely the index value for October     
2004.
  
 If the index value should rise in relation to the base number in
any subsequent October, an addition shall be paid with the percentage by which the index value is changed in relation to the base number. In the continuation, the addition shall be paid in relation to the index changes, whereby the change in rent is
calculated on the basis of the percent change between the base number and the index number for the respective October.

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	 Page 
 27
(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

					
		  	 Outgoing rent, however, shall never be set lower than the rent amount specified in the contract. The change in rent
always occurs as of January 1 after the October index occasions the recalculation.
  
 The instructions on page 2 are applicable to the agreement.

	  
 Signature
	  	  
 Place/date

[handwritten:] 05/05/31
	  	  
 Place/date

[handwritten:] Bagsværd

	  	  
 Landlord
 i-parken i Lund AB
	  	  
 Tenant
 Novozymes Biopharma AB
 [signature]

	  		  	  
 Printed name    [stamp:] Arne W.
Schmidt
       Group Director

		  	  
 [signature]

Christopher Nilsson
	  	  
 Tenant
 [signature]

		  	  	  
 Printed name    [stamp:] Niels
Münter
       Legal Counsel

      Novozymes A/S
       Krogshoejvej 36

      DK-2880 Bagsværd

 The Landlord’s own entry on base number: 281 

 
  
 The Swedish Property Owners’ Association form no. SE, prepared in 1999 in consultation with the Swedish Trade Federation and the Swedish Hotel and Restaurant Association. The copy of the
instructions was revised in May 2002. Reprinting is prohibited. 
 Lic. no.: 2160-3442-6750-20. Version no. 6.0. Licensed to: Realia
Fastighets AB. 
 Page 2 (2) 
 Instructions for the Index Clause for Office Space 
 The Base Rent 

Whether the whole or some part of the rent amount specified in this agreement should constitute the base rent is a matter for negotiation, and may
otherwise depend on the lease 

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	 Page 
 28
(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

 
terms (such as, for example, the rent’s size in
SEK/m2 and the year, as well as the other obligations that
are incumbent upon the Tenant, etc.). 
 The Base Number 
 The index number for October, to which the base rent is considered to be adjusted, makes up the base number unless otherwise indicated by indicating the year (see the provisions on page 1). 

A comparison of indices occurs as soon as the year’s October index is published. In recent years, the October index has been published in
mid-November. 
 Calculation of the rent supplement 
  

	 	4)	Calculate the difference between the current October index and the base number. 

 

	 	5)	If the difference is positive, the calculated difference is divided by the base number. 

 

	 	6)	The size of the rent supplement is calculated by this quotient, multiplied by the base rent. 

 Example 
 Calculation of rent supplement for the year 2002 

The base rent is assumed to be 100,000 SEK/year and is adjusted to the consumer price index (CPI) for October 1999, which is 259.7 (Base number). The
October index for the year 2001 is 269.1. 
  

	 	3.	Calculate the difference between the index number 269.1 and 259.7. The difference is positive and adds up to 9.4. 

 

	 	4.	Divide 9.4 by 259.7 and multiply the quotient (without rounding) by the base rent 100,000 SEK. The result is 3,619.56 SEK and constitutes the rent supplement for the
year 2002 according to the clause. 

 Alternative A: If the CPI for October 2001 should instead end up being lower than the
year before, e.g. 262.0 (October index for year 2000 was 262.6). 

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	 Page
 29
(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

 The difference between the assumed 262.0 and the base number 259.7 would still have been positive and
added up to 2.3. The quotient between 2.3 and the base number 259.7, multiplied by the base rent 100,000 SEK would have resulted in a rent supplement of 885.63 SEK. The total rent, however, would have been lower than for the year 2001. 

Alternative B: If the CPI for October 2001 should instead end up being lower than the base number 259.7, e.g. 259.5. 

The difference between 259.5 and the base number 259.7 would have then been negative. No rent supplement should then be paid. The rent amount specified
in the agreement should apply. 
  

					
		  		  	[initials]
	[logo]	  	INDEX CLAUSE	  	
	 Page 1 (2)
	  		  	
	THE PROPERTY OWNERS’ ASSOCIATION	  	for office space	  	
	 Appendix no.
	  		  	

  

					
		  	 2       
	  	
	Concerning	  	Lease contract no.	  	for the property
		  	33001 7722 02	  	Hennerup
	Landlord	  	 i-parken i Lund AB

556263-8394

	Tenant	  	Novozymes Biopharma AB, 556627-0830
	Clause	  	 The applicable option is marked with a cross in the box and filled in with the required information.

 
 To the extent that the portions of the property that consist of the office space
should be/are liable to property taxes, the Tenant shall pay the Landlord compensation for this along with the rent, according to the marked option.
  

x  In addition to the rent amount specified in the contract, the Tenant shall annually pay for
compensation for his share of outgoing property taxes for the office space on each occasion. The Tenant’s share shall be considered to be 14.9 percent.
  

According to the rules that apply at the time of the signing of the contract, the compensation constitutes 171,605 SEK per year at the start of the lease
period.

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	 Page
 30
(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

											
		  	  ̈  Compensation for the share of the property taxes accruing at
the office space is included in the rent amount specified in the agreement and constitutes              SEK at the time of the signing of the agreement.

		  	  
 The office space’s share of the property taxes
for the office space shall be considered to be percent. The Tenant shall pay compensation for his share of changes that occurred (regardless of the reason for them) in the property taxes for the office space, after the signing of the agreement, to
the extent that the taxes exceed the compensation for the property taxes that is included in the rent.
  
 If the property taxes should happen to decrease/cease, with the result that the Tenant’s share of the compensation is less than the compensation that is included in the rent specified in the
agreement, in accordance with the above, however, the rent shall at least amount to the original amount. Other clauses (e.g. index) found in the agreement thus entail that the total rent amount that the Tenant pays is/may be higher than the rent sum
specified in the agreement.
  
 The Tenant’s share specified above,
which shall be unaltered during the rental period, has been calculated according to the following:
  

 
  
  

The instructions on page 2 are applicable to the agreement.

	Signature	  	 Place/date

[handwritten:]    05/05/31
	  		  	 Place/date

[handwritten:] Bagsværd 05/27/05

		  	 Landlord
  
 i-parken i Lund AB
 [signature]
	  	 Tenant
  

[signature]    [signature]

		  	Christopher Nilsson	  	 Printed name 

[stamp:] Arne W. Schmidt 

              Group Director 
	 	 [stamp:]
	  	 Niels Münter

Legal Counsel

Novoyzmes A-S

Krogshoejvej 36

DK-2880 Bagsværd

  
  
 The Swedish Property Owners’ Association form no. 78, prepared in 1995. Section 2 of Instructions, revised in 1997. Reprinting is prohibited. 

Lic. no.: 2160-3442-6750-20. Version no. 6.0. Licensed to: Realia Fastighets AB. 

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	 Page
 31
(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

 INSTRUCTIONS 
 Page 2(2) 
 1. 

The clause was formulated in June 1995, i.e. before the time (usually January 1, 1996) from which the property taxes apply for the office space. The
clause therefore has a wording that means that this can be introduced into the agreement that is signed before the taxes are paid, as well as in the agreement that is signed when the taxes are actually paid. 

2. 
 The compensation
shall compensate for increased administrative costs, regardless of who is actually liable for tax. Property owners / Landlords are liable for tax. If partnerships are property owners / Landlords, according to previous rules, shareholders are liable
for tax. The rent supplement would of course yet be paid to the Landlord. After January 1, 1997, however, partnerships, as owners, are liable for property taxes. 
 3. 
 According to § 19 of the Rent Act, the rent – with some
exceptions – shall be the amount determined in the rent agreement. If the lease period is determined and for at least three years, moreover, a reservation applies that the rent shall be paid by the amount that is determined according to
“another basis for calculation,” e.g. adjustment of the index. This also means that the lease term must be determined at least three years before the Landlord shall be able to charge compensation for property taxes, with an amount that can
vary according to the change in the tax. Furthermore, the basis for calculation must be specified in the agreement. The clause therefore assumes that the parties will indicate for how large a share of the tax the Tenant must pay compensation.

 According to the rules that are applicable at the time of this clause’s preparation, the tax constitutes a certain percent of the
assessment value for the office space (both land and buildings). The declaration is reported in the tax information. The Tenant’s share of the tax for the office space can be determined as the relationship between the area that the Tenant rents
and the rentable area of the property, or as the relationship between the Tenant’s rent and the total rents on the property. 
 What rate
of calculation the parties select becomes a matter for negotiation. Other bases for calculation can also be used. For the sake of simplicity, however, the Tenant’s share should be unchanged during the lease term and, thus, independent of, for
example, how the taxes can continue to be calculated, and any changes in the position of the rent. 
 It is appropriate, therefore, to indicate
at the intended place how the office space’s share has been calculated. If the information relating to this should happen not to be filled in, this shall not mean, however, that the agreement becomes invalid. On a property, various buildings
can be found with various values and various types of assessable units (single-family home, apartment building, industrial facility, and special unit). The tax – for which the Tenant shall pay compensation – shall only relate to the
building where the office space is located. A building usually refers to each structural body. Required information can be retrieved from the notification of the decision about general property assessment which the Tax Agency sends to the property
owner. The property owner who has problems calculating the Tenant’s share should contact his property owner’s association for assistance. 

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	 Page
 32
(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

 Fill in the Tenant’s share! 

4. 
 The clause contains
two options. In the first, compensation is paid for tax as a rent supplement “alongside” the rent amount specified in the agreement. The tax and the rent supplement disappear automatically. The other option assumes that the parties are in
agreement about a certain rent in which, for instance, compensation for the applicable tax is included. If the tax should happen to be raised, regardless of the reason (e.g. high tax rate, increased tax assessment value, etc.) the Tenant shall
nevertheless pay compensation for the increased cost. If the tax should happen to disappear, the rent returns to the original amount, i.e. the agreed upon rent (which includes compensation for the initially applicable tax which ceased). Naturally
the Tenant shall still pay other rent supplements that occur, such as for changes in the index, changes in fuel costs, etc. 

5. 
 To the extent that
the Tenant shall pay a rent supplement for property taxes, the rent supplement should be reported separately on the rent specification. 
 6. 
 Mark with cross the option which you have selected. In the option
selected, the Tenant’s share and the current amount are indicated. Furthermore, indicate how the Tenant’s share is calculated. 
 [initials] 
 [logo] 
 Page 1 (1) 
 THE PROPERTY OWNERS’ ASSOCIATION 

Appendix no. 3 

The undersigned have today made an agreement concerning the following supplement to lease contract no. 33001 7722 02 

 

			
	Landlord	  	i-parken i Lund AB, 556263-8394
		
	Tenant	  	Novozymes Biopharma AB, 556627-0830
		
	Property	  	Hennerup
		
	Supplement	  	The Tenant shall take over and pay for service of existing and new ventilation and water and sewage plants. Realia (the Landlord) shall provide consumable materials on an ongoing
basis.

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	 Page
 33
(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

											
		  	 This agreement replaces lease contract 33001 7722 01, 33001 7758 01 and 33001 7759 01.

 

	Signature	  	 Place/date

[handwritten:]    05/05/31
	  	 Place/date

[handwritten:] Bagsværd 05/27/05

	  		  		  		 		  	
	  	 Landlord
  

i-parken i Lund AB
 [signature]

Christopher Nilsson
	  	 Tenant
  

[signature]    [signature]
	 		  	
		  	  	  
 Printed name 

[stamp:] Arne W. Schmidt 

              Group Director 
	 	  
 [stamp:]
	  	  
 Niels Münter

Legal Counsel
 Novoyzmes
A-S
 Krogshoejvej 36

DK-2880 Bagsværd

 The Swedish Property Owners’ Association Form for free text to be used together with the Property Owners’
Association’s other contract forms. 
 Lic. no. 2160-3442-6750-20. Version no. 6.0. Licensed to: Realia Fastighets AB.

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	Page 34(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

																																	
	  
 Landlord
	 	 	 	  
 I-Parken i Lund AB
	 	  
 National
ID/company registration no.
	 	 
	 	 			 
	 	 	 	 	 	 	556263-8394	 	 
	  

Tenant
	 	 	 	  
 Novozymes
Biopharma AB
	 	 	 	  
 National ID/company registration no.
	 	 
	 	 						 
	 	 	 	 	 	 	 	  	 	  	 	 	556627-0830	 	 
	 	 						 
	Tenant (2)	 	 	 	 	 	 	  	 	  	 	 	National ID/company registration no.	 	 
	  
 Premise Address, etc.
	 	 	 	  
 Municipality
  

Lund
	  	  
 Property
designation
  
 Hunnerup 1
	 	 
	 	 	  
 Street address
  
 S.t Lars
Väg 44
	 	  
 Stairs/house
  

BV
	 	  
 Apartment
no.
	 	 
	 	 	  
 Billing address:
  
 Box 965,
220 09 LUND
	 	 	 	 	 	 
	  

Condition and use of the office space
	 	 	 	  
 Unless
otherwise indicated, the office
space                                    Storage/Changing
room
  
 with associated facilities is being leased for use
as:
	 	 
	  
 Size and extent of the office space
	 	 	 	  
 Shop
area
	  	  
 Office area
in
	  	  
 Storage area
in
	  	  
 Other area
	 	 
	 	 	  
 plan  
	  	  
 m2    
	  	  
 plan    
	  	  
 m2    
	  	  
 plan    
	  	  
 m2    
	  	  
 Plan    
  

Ca
  
 BV
	  	  
 m2
  
 Approx.
  

[hw:] 440    
	  	  
 plan    
	  	  
 m2
	 	 
	 	 	  
 The indicated
areas                                        
                                         
   [signature]
  

 ̈ have
        x Have not            been measured jointly prior to the execution of the
Agreement
  
 Should the area shown in the Agreement deviate from that
actually measured, this does not entitle the Tenant to any repayment of rent nor entitle the Landlord to any increased rent
  
 x The extent of the leased premises is marked on appended plan(s)
	 	  

Appendix 5
	 	 
	 	 	  
 access for cars loading and unloading
  
  ̈
	  	 place for sign  

 
  ̈
	  	  
 place for display cabinet / vending machine
  
  ̈
	 	 parking space(s) for 

 

 ̈        car(s)
	 	  

garage space(s)  
 for
cars
  
  ̈
	 	 ̈	 	 

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 
  

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	Page 35(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

					
	Furnishings, etc.	  	 The premises are let
  

x without
furnishings                     ̈ with furnishings/fixtures/fittings

 
     specific to the Tenant’s use
of            specific to Tenant’s use of the premises according to appendix
  

the premises
  
 Unless otherwise agreed upon, at the termination of the tenancy, the Tenant shall remove all property belonging to him and surrender the premises in acceptable condition.

 
 The parties agree to carry out a joint inspection of the premises not later than the
last day of the tenancy. If, as a result of the Tenant’s actions – carried out with or without the Landlord’s consent – the premises upon surrender should contain material, which had not previously been agreed that the Landlord
should be responsible for, the Tenant shall remove such material or pay the Landlord’s expenses in so doing, including but not limited to, transportation costs, waste disposal taxes and storage charges.
	  	Appendix
		
	Telephone lines	  	x The Tenant shall pay for the installation of the necessary telephone lines from a connection point designated by the
service provider to those points in the premises chosen by the Tenant in consultation with the Landlord.
		
		  	 ̈ The Landlord shall pay for the corresponding installation of lines to the premises. The installation of the lines
inside the premises shall be carried out by the Tenant in consultation with the Landlord; the cost, however, to be borne by the Tenant.
		
	 Data communication

lines
	  	x The Tenant shall pay for the installation of the necessary data communication lines from a connection point designated
by the service provider to those points in the premises chosen by the Tenant in consultation with the Landlord.
		
		  	 ̈ The Landlord shall pay for corresponding installation of lines to the premises. The installation of lines inside the
premises shall be carried out by the Tenant in consultation with the Landlord; the cost, however, to be borne by the Tenant.
		
	Term of lease	  	
Commencing                        
                                         
   Up to and including
  

01/10/2009                        
                                         
       09/30/2014

		
	Termination/extension	  	 Notice of termination of this Agreement must be given in writing at least 9 months prior to the expiry of this
Agreement.
  
 In the absence thereof, this Agreement is extended by a term of
3 years at a time.

		
	Heating and hot water	  	 Requisite heating of the premises is provided
by                    x the
Landlord                     ̈ the Tenant

 
 Hot water is
provided    x throughout the year                        ̈ not provided

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	Page 36(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

									
	  
 Rent
	 	  
 SEK

 
 396,000         Per annum
comprising     ̈ total rent    x rent excl. supplements marked Appendix

			
	Index clause	 	x Changes to the above-stated rent shall be effected pursuant to the appended index clause	 	App. 1
			
	Heating and hot water costs	 	x Fuel/heating supplement payable in accordance with appended clause Special provisions	 	App 4
			
	Water and sewerage costs	 	x Water/sewerage supplement payable in accordance with appended clause	 	App 4
			
	Cooling Ventilation	 	 ̈ Costs for the operation of special cooling and ventilation appliances shall be reimbursed in accordance with appended
clause	 	App.
			
	Electricity	 	 ̈ included in
rent                                    x Tenant has own contract with the provider	 	
			
	Cleaning of stairwell	 	x included in
rent                                     ̈ arranged for and paid for by the Tenant	 	

							
		
	Refuse and waste removal	 	 Insofar as the Landlord is responsible for the provision of storage space for refuse/waste, and arranging for the removal of
such refuse/waste, it is the Tenant’s responsibility to sort and deposit refuse/waste in the appropriate containers as directed, in their designated place, as well as without recompense contribute towards further and/or additional sorting, as
directed by the Landlord.
  
 Refuse and waste removal

 
  ̈ included in rent

 
 x arranged for and paid for by
the Tenant
  
  ̈ included
in rent with respect to the types of refuse/waste indicated below. The Tenant shall be responsible for, and pay for the costs of, collection, sorting, storage and transportation of the categories of refuse/waste not indicated below which are to be
found on the Tenants premises.

		 	  
  ̈ household
waste
  
  ̈ heavy
refuse
  

 ̈ compostable waste

 
  ̈ newspapers

 
  ̈ batteries

 
	 	  
  ̈ fluorescent
tubes
  
  ̈ metal
packaging
  
  ̈ clear glass
containers
  
  ̈ colored glass
containers
  
  ̈ cardboard
packaging
	  	  
  ̈ hard plastic
packaging
  
  ̈ Hazardous
waste pursuant to the Hazardous Waste Ordinance (1996:971)
  
  ̈                                  
              
  
  ̈                         
                       
  

 ̈                 
                               

		
	Snow clearance and gritting	 	x included in
rent         ̈ to be arranged for and paid by the
Tenant         ̈ as per App.        App.

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	Page 37(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

			
	Property taxes	  	 ̈ included in
rent                    x reimbursement payable as per special
agreement                    App. 2
		
	Unforeseen costs	  	 Where, following the execution of this Agreement, unforeseen increases in costs arise in relation to the property as a consequence
of:
  

a)      the introduction of, or increase in taxes, charges or duties levied
specifically on the property as a result of decisions taken by the Parliament, Government, municipalities, or other relevant authorities;
  

b)      general rebuilding measures or suchlike in respect of the property which do
not relate solely to the premises and which the Landlord is obliged to execute as a result of decisions of the Parliament, Government, municipalities or other relevant authorities;

 
 The Tenant shall, commencing at the time of the cost increase, reimburse the Landlord
in relation to that proportion of the total annual increase in costs for the property represented by the premises.
  
 The proportion represented by the premises is 2.222 percent. Where the proportion has not been indicated, it shall be comprised of that proportion of the total rents for premises (excluding any
value-added tax) represented by the Tenant’s rent (excluding any value-added tax) at the time of the increase in costs. For unleased premises, the market rent for the premises shall be estimated.

 
 ‘Taxes’ in accordance with a) above does not refer to value-added tax and
property tax to the extent that reimbursement in respect of this is paid as per agreement. ‘Unforeseen costs’ means such costs as were not decided upon by the authorities as set forth in sections a) and b) at the inception of the
Agreement. Reimbursement shall be paid in the same manner as set forth below for rental payments.

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	Page 38(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

							
		
	Value-added tax (VAT)	  	 x The property owner/Landlord is liable to pay value-added tax for the
letting of the premises. In addition to rent, the Tenant shall on each occasion pay the VAT currently applicable.
  
  ̈ Where, following a decision by the Tax Authorities, the property owner/Landlord becomes liable to pay VAT for the letting of the premises, the Tenant
shall on each occasion in addition to the rent pay the VAT currently applicable.
  
 The VAT paid together rent shall be calculated on the stated rental amount and where applicable on supplemental charges and other reimbursements paid in accordance with the Agreement, pursuant to the
rules applicable at the time in respect of VAT payable on rent.
  
 Where the
Landlord becomes liable to pay VAT pursuant to the provisions of the Value Added Tax Act as a consequence of the Tenant’s independent actions, such as a subletting of the premises (including subletting to its own company) or assignment, the
Tenant shall reimburse the Landlord in full. In addition, the Tenant shall reimburse the Landlord in respect of the increased costs arising as a consequence of the Landlord’s loss of the entitlement to deduct VAT on operating expenses incurred
as a consequence of the Tenant’s actions.

		
	Payment of rent	  	 The rent shall be paid in advance without prior demand, not later than the last Postal giro no.
             Bank giro no.             working day prior to the commencement of

 ̈ each calendar month         x each quarter             by direct transfer to either
of             258-9711

                       
                   the following accounts

		
	Interest, Payment reminders	  	Upon delay in the payment of rent, the Tenant shall pay interest in accordance with the Interest Act as well as compensation for written payment reminders in accordance
with the Debt Recovery Act, etc. Compensation for payment reminders shall on each occasion be paid in an amount currently applicable pursuant to the Debt Recovery Ordinance, etc.
				
	Maintenance, etc.	  	 ̈ The Landlord shall carry out and bear the cost of necessary maintenance of the premises and furnishings/fittings/fixtures supplied
by him.	  	However, the Tenant shall be responsible for	 	Appendix

							
				
		  	 x The Tenant shall carry out and bear the cost of necessary maintenance of the surface of floors,
walls and ceiling, as well as of furnishings/fittings/fixtures provided by the Landlord.
	  	 The Tenant’s maintenance obligation includes

 
 Changing of fluorescent lamps/glow starters Service &
maintenance of doors
	 	 Appendix

		
		  	 Where the Tenant does not fulfill his maintenance obligations and does not within a reasonable time carry out rectification works
following a written demand, then the Landlord shall be entitled to fulfill these obligations at the Tenant’s expense.

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	Page 39(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

					
		  	  ̈  The allocation of the maintenance obligations is set forth as per
separate appendix. 
	  	Appendix
		
	Management and operation	  	 Unless otherwise agreed, the Landlord shall, where applicable, manage, operate, and maintain the public and common
areas.
  
 The Tenant shall be entitled, without the Landlord’s written
consent, to carry out any fitting and/or installation or alteration works within the premises or otherwise within the property, which directly affects the structural components of the building or installations important to the functioning of the
property, such as water and sewage, electricity, ventilation systems, etc., which are the property of the Landlord.
  
 Sprinkler heads and ventilation equipment may not be covered by any fixtures/fittings by the Tenant in such a manner as to reduce the functioning of such equipment. In conjunction with the performance of
fitting out works, the Tenant shall ensure that the functioning of radiators and other heating equipment is maintained in all significant respects.

		
	Inspections	  	Where any defects and/or deficiencies are found subsequent to an inspection by a relevant authority, in the electrical and sprinkler equipment is the property of the
Tenant, the Tenant shall, at his own cost and within the period prescribed by the relevant authority, carry out any measures required. Where the Tenant has not rectified the defects and/or deficiencies within the stated time, the Landlord shall be
entitled, at the Tenant’s expense, to carry out such measures as are required by the relevant authority.
		
	Access to certain spaces	  	The Tenant shall keep areas to which the maintenance to personnel and personnel from the energy utilities, water and sewage utilities, the telephone company, and any
like organization must have access to, easily accessible by keeping such areas free of cupboards, crates, goods, or any other obstruction.
		
	Building material specifications	  	Whether, pursuant to the provisions of this Agreement or otherwise, the Tenant performs maintenance, improvement, or alteration works in respect of the premises, the
Tenant shall provide the Landlord, in good time prior to the execution of such work, with specification of the building materials – to the extent such have been prepared – for the products and materials to be used on the
premises.
		
	Planning and Building Code (PBL) fines	  	When the Tenant undertakes alterations to the premises without the requisite construction permit and, as a consequence thereof the Landlord is compelled to pay
construction fines or supplemental fees pursuant to the rules set forth in the Planning and Building Code (PBL), the Tenant shall reimburse the Landlord in respect of this.
		
	Reduction of rent	  	The Tenant shall not be entitled to a reduction in rent for the period during which the Landlord allows work to be carried out in order to place the premises in the
agreed condition, or other works specifically set forth in the Agreement.
			
		  	  ̈  The Tenant’s right to a reduction in rent during the
Landlord’s performance of customary 
	  	 Appendix

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	Page 40(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

							
		 	maintenance of the leased premises or the property shall be governed by a separate appendix.
				
	Requirement imposed by relevant authorities, etc.	 	 ̈ The Landlord	 	x The Tenant	 	
		
		 	shall be solely responsible for, and bear the cost of, undertaking measures which may be required for the intended use of the premises by insurance companies, building
authorities, environmental or health authorities, fire departments, or other relevant authorities after the date of taking possession. The Tenant shall consult with the Landlord prior to undertaking any such measures.

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	Page 41(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

											
	Signs, awnings, windows, doors, etc.	  	 Following consultation with the Landlord, the Tenant shall be entitled to display a customary business sign, provided that
the Landlord has not reasonably denied the same and that the Tenant has obtained the requisite permit from the relevant authority. Upon surrender of the premises, the Tenant shall restore the facade of the building to an acceptable
condition.
  
 In conjunction with more extensive property maintenance, such
as the renovation of facades, etc, the Tenant shall, at his own cost and without compensation, dismantle and reassemble signs, awnings, and antennas.
  

The Landlord undertakes not to fix vending machines and display cabinets on the exterior walls of the premises let to the Tenant without the Tenant’s
consent, and grants to the Tenant an option to fix vending machines and display cabinets on the walls in question.

	  	  
  ̈ The
Landlord
 x The Tenant is liable for any damage due to negligence or malicious intent
to

	  		  	x windows	  	 ̈ display/shop windows	  	x entrance doors
		  		  	x signs 	  	x Damage due to breaking/entering/robbery

											
		
		 	x The Tenant shall purchase and maintain glass insurance with respect to all display/shop windows and entrance doors
appurtenant to the premises.
			
	Locks	 	  ̈ The Landlord 
	  	x The Tenant shall equip the premises with such locks and anti-theft devices as may be required to ensure the validity of
the Tenant’s business insurance.

											
		
	Force majeure	 	The Landlord shall not be compelled to perform his obligations under this Agreement or pay any damages where, as a consequence of acts of war or riots, work stoppages,
blockades, fires, explosions, or intervention by a public authority over which the Landlord has no control and which could not have been foreseen, and the Landlord is prevented entirely from performing his obligations or may only be able to do so at
abnormally high cost.

											
			
	Security	 	 This Agreement is contingent upon the provision of security in the form of a 
	  	Appendix
					
		 	 ̈ Bank guarantee 	  	 ̈ Personal guarantee	  	 ̈ To be provided no later than	  	
			
	 Special provisions
	 		  	Appendix
			
		 	 – Value added tax clause
	  	 3

			
		 	 – Special provisions 
	  	4 

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

					
		  	LEASING AGREEMENT        	  	Page 42(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 4301-7804-00

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

							
	Signature	  	This Agreement, which may not be registered without specific consent, has been prepared in two identical copies of which each party has received one. All prior
agreements between the parties with respect to these premises shall cease to apply commencing on the date of the execution of this Agreement.
			
		  	Place/date	  	Place/date
			
		  	 [hw:] Malmö 26/03/2009
	  	
				
		  	 Landlord
  
 I-Parken i Lund AB
  

[signature]
	  		  	 Tenant
  
 Novozymes Biopharma AB
  

[signature]

			
		  	 Printed name [signature]
  

[stamp:] Peter Olsson    [stamp:] Johan Sjöstedt 
	  	 Printed name
  

[hw:] Mikael [illegible]

							
		
	Agreement with respect to the surrender of the premises	  	As a consequence of an agreement entered into on this day, the Agreement shall cease to apply commencing
                                 at which time the Tenant undertakes to surrender the
premises.
	  	  
 Place/date
	  	  
 Place/date

			
		  	Landlord	  	Tenant

							
		
	Assignment	  	This Lease Agreement is hereby assigned to
                         commencing
                        
	  		  		  	
		  	Assignor	  	Assignee (New Tenant)	  	National ID/co. registration no. 
				
	The above referenced assignment is hereby approved	  	Place/date	  	Landlord	  	

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 

					
		  	Initial	  	Initial
		 	 
	License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB	  	[initialled]	  	 

							
	[logo]	  		  	INDEX CLAUSE                    	  	Page 1(2)
	THE SWEDISH PROPERTY FEDERATION	  	 FOR NON-RESIDENTIAL PREMISES    

 

 Appendix no. 1 

 

					
	Concerns	  	 Lease contract no.
  

4301-7804-00
	  	 in the property
  

Hunnerup 1

		
	Landlord	  	I-Parken i Lund AB, 556263-8394
		
	Tenant	  	Novozymes Biopharma AB, 556627-0830
		
	Clause	  	 Of the rent amount specified in the contract, 396,000 SEK, 100% or 396,000 SEK shall constitute the
base rent. During the lease period, an addition to the rent amount shall be paid with respect to changes in the consumer price index (total index with 1980 as the base year), with a certain percent of the base rent, according to the reasons below.

  

•    For lease agreements that begin at any time during the period 01/01
– 06/30, the base rent is adjusted to the index value for October of the previous year.
  

•    For lease agreements that begin at any time during the period 07/01 –
12/31, the base rent is instead adjusted to the index value for October of the same period.
  

•    The index value for October, to which the base rent is considered to be adjusted
in accordance with the above, constitutes the base number unless otherwise agreed upon as follows by indicating the year. Otherwise agreed upon base number, namely the index value for October 2010.

 
 If the index value should rise in relation to the base number in any subsequent
October, an addition shall be paid with the percentage by which the index value is changed in relation to the base number. In the continuation, the addition shall be paid in relation to the index changes, whereby the change in rent is calculated on
the basis of the percent change between the base number and the index number for the respective October.
  
 Outgoing rent, however, shall never be set lower than the rent amount specified in the contract. The change in rent always occurs as of 1 January after the October index occasions the
recalculation.
  
 The instructions on page 2 are applicable to this
agreement.

			
	Signature	  	 Place/date 
  
 [handwritten:] Malmö 03/26/2009
	  	Place/date

  
  
 Swedish Property Federation form no. 6EB, prepared in 1999 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). 

The examples in the manual were revised in May 2002. Copying prohibited. 
 Lic. no.: 2160-9981-2121-41. Version no.: 6.5 Licensed to: Sveareal AB 

					
		 	 Landlord
	  	 Tenant

		 	  
 I-Parken i Lund AB
	  	 Novozymes Biopharma AB 

	 	  	  
 Printed name        [hw:]
MIKAEL BUNDGAARD-NIELSEN

			
		 		  	 Tenant

			
		 	[signature]	  	[signature]
			
		 	 Printed name
	  	Printed name
			
		 	Peter Olsson / Johan Sjöstedt	  	

 The Landlord’s own entry on base number: 

 Page 2(2) 

 

 Instructions for the Index Clause for Non-Residential Premises 

The Base Rent 

Whether the whole or some part of the rent amount specified in this agreement should constitute the base rent is a matter for
negotiation, and may otherwise depend on the lease terms (such as, for example, the rent’s size in
SEK/m2 and the year, as well as the other obligations that
are incumbent upon the Tenant, etc.). 
 The Base Number 
 The index number for October, to which the base rent is considered to be adjusted, makes up the base number unless otherwise indicated by indicating the year (see the provisions on page 1). 

A comparison of indices occurs as soon as the year’s October index is published. In recent years, the October index has been published in
mid-November. 
 Calculation of the rent supplement 
  

	 	7)	Calculate the difference between the current October index and the base number. 

 

	 	8)	If the difference is positive, the calculated difference is divided by the base number. 

 

	 	9)	The size of the rent supplement is calculated by this quotient, multiplied by the base rent. 

 Example 
 Calculation of rent supplement for the year 2002 

The base rent is assumed to be 100,000 SEK/year and is adjusted to the consumer price index (CPI) for October 1999, which is 259.7 (Base number). The
October index for the year 2001 is 269.1. 
  

	 	5.	Calculate the difference between the index number 269.1 and 259.7. The difference is positive and adds up to 9.4. 

 

	 	6.	Divide 9.4 by 259.7 and multiply the quotient (without rounding) by the base rent 100,000 SEK. The result is 3,619.56 SEK and constitutes the rent supplement for the
year 2002 according to the clause. 

 Alternative A: If the CPI for October 2001 should instead end up being lower than the
year before, e.g. 262.0 (October index for year 2000 was 262.6). 
 The difference between the assumed 262.0 and the base number 259.7 would
still have been positive and added up to 2.3. The quotient between 2.3 and the base number 259.7, multiplied by the base rent 100,000 SEK would have resulted in a rent supplement of 885.63 SEK. The total rent, however, would have been lower than for
the year 2001. 

 Alternative B: If the CPI for October 2001 should instead end up being lower than the base number 259.7,
e.g. 259.5. 
 The difference between 259.5 and the base number 259.7 would have then been negative. No rent supplement should then be paid.
The rent amount specified in the agreement should apply. 

							
	[logo]	  		  	INDEX CLAUSE                    	  	Page 1(2)
		
	THE SWEDISH PROPERTY FEDERATION	  	 FOR NON-RESIDENTIAL PREMISES    

 

 Appendix no. 2 

 

					
	Concerns	  	 Lease contract no.
  

4301-7804-00
	  	 for the property
  

Hunnerup 1

		
	Landlord	  	I-Parken i Lund AB, 556263-8394
		
	Tenant	  	Novozymes Biopharma AB, 556627-0830
		
	Clause	  	 The applicable option is marked with a cross in the box and filled in with the required information.

 
 To the extent that the portions of the property that consist of the office space
should be/are liable to property taxes, the Tenant shall pay the Landlord compensation for this along with the rent, according to the marked option.
  

x In addition to the rent amount specified in the contract, the Tenant shall annually pay for compensation
for his share of outgoing property taxes for the office space on each occasion. The Tenant’s share shall be considered to be 2.222 percent.
  

According to the rules that apply at the time of the signing of the contract, the compensation constitutes 38,880 SEK per year at the start of the lease
period.
  
  ̈ Compensation for
the share of the property taxes accruing at the office space is included in the rent amount specified in the agreement and
constitutes                    SEK at the time of the signing of the agreement.

		
		  	 The office space’s share of the property taxes for the office space shall be considered to be percent. The Tenant shall
pay compensation for his share of changes that occurred (regardless of the reason for them) in the property taxes for the office space, after the signing of the agreement, to the extent that the taxes exceed the compensation for the property taxes
that is included in the rent.
  
 If the property taxes should happen to
decrease/cease, with the result that the Tenant’s share of the compensation is less than the compensation that is included in the rent specified in the agreement, in accordance with the above, however, the rent shall at least amount to the
original amount. Other clauses (e.g. index) found in the agreement thus entail that the total rent amount that the Tenant pays is/may be higher than the rent sum specified in the agreement.

 
 The Tenant’s share specified above, which shall be unaltered during the rental
period, has been calculated according to the following: 

 Swedish Property Federation form no. 7B, prepared in 1995. Point 21. Guidelines revised in 1997. Copying prohibited.

 Lic. no.: 2160-9981-2121-41. Version no.: 6.5 Licensed to: Svereal AB 

					
		  	The instructions on page 2 are applicable to the agreement.
			
	Signature	  	 Place/date

[handwritten:]      Malmö 03/26/2009
	  	Place/date
	  	  
 Landlord
	  	  
 Tenant

	  		  	  
 Novozymes Biopharma AB

			
		  	I-Parken i Lund AB	  	[signature]
		  	[signature] [signature]	  	
			
		  	 Printed name
	  	 Printed name

		  	Peter Olsson / Johan Sjöstedt	  	[hw:] MIKAEL BUNDGAARD-NIELSEN

			
	INSTRUCTIONS	  	Page 2(2)

  

 1. 
 The clause was formulated in June 1995, i.e. before the time (usually 1 January 1996) from which the property taxes apply for the office space. The clause therefore has a wording that means that this
can be introduced into the agreement that is signed before the taxes are paid, as well as in the agreement that is signed when the taxes are actually paid. 
 2. 
 The compensation shall compensate for increased administrative costs, regardless of who
is actually liable for tax. Property owners / Landlords are liable for tax. If partnerships are property owners / Landlords, according to previous rules, shareholders are liable for tax. The rent supplement would of course yet be paid to the
Landlord. After January 1, 1997, however, partnerships, as owners, are liable for property taxes. 
 3. 

According to § 19 of the Rent Act, the rent – with some exceptions – shall be the amount determined in the rent agreement. If the lease
period is specified, and for a period of at least three years, reservations also apply that the rent shall be paid in the amount determined according to “another basis for calculation,” e.g. adjustment of the index. This also means that
the lease term must be determined at least three years before the Landlord shall be able to charge compensation for property taxes, with an amount that can vary according to the change in the tax. Furthermore, the basis for calculation must be
specified in the agreement. The clause therefore assumes that the parties will indicate for how large a share of the tax the Tenant must pay compensation. 
 According to the rules that are applicable at the time of this clause’s preparation, the tax constitutes a certain percent of the assessment value for the office space (both land and buildings). The
declaration is reported in the tax information. The Tenant’s share of the tax for the office space can be determined as the relationship between the area that the Tenant rents and the rentable area of the property, or as the relationship
between the Tenant’s rent and the total rents on the property. 
 What rate of calculation the parties select becomes a
matter for negotiation. Other bases for calculation can also be used. For the sake of simplicity, however, the Tenant’s share should be unchanged during the lease term and, thus, independent of, for example, how the taxes can continue to be
calculated, and any changes in the position of the rent. 
 It is appropriate, therefore, to indicate at the intended place how
the office space’s share has been calculated. If the information relating to this should happen not to be filled in, this shall not mean, however, that the agreement becomes invalid. On a property, various buildings can be found with various
values and various types of assessable units (single-family home, apartment building, industrial facility, and special unit). The tax – for which the Tenant shall pay compensation – shall only relate to the building where the office space
is located. A building usually refers to each structural body. Required information can be retrieved from the notification of the decision about general property assessment which the Tax Agency sends to the property owner. The property owner who has
problems calculating the Tenant’s share should contact his property owner’s association for assistance. 

 Fill in the Tenant’s share! 
 4. 
 The clause contains two options. In the first, compensation is paid for tax as a rent
supplement “alongside” the rent amount specified in the agreement. The tax and the rent supplement disappear automatically. The other option assumes that the parties are in agreement about a certain rent in which, for instance,
compensation for the applicable tax is included. If the tax should happen to be raised, regardless of the reason (e.g. high tax rate, increased tax assessment value, etc.) the Tenant shall nevertheless pay compensation for the increased cost. If the
tax should happen to disappear, the rent returns to the original amount, i.e. the agreed upon rent (which includes compensation for the initially applicable tax which ceased). Naturally the Tenant shall still pay other rent supplements that occur,
such as for changes in the index, changes in fuel costs, etc. 
 5. 
 To the extent that the Tenant shall pay a rent supplement for property taxes, the rent supplement should be reported separately on the rent specification. 

6. 
 Mark with cross the option which
you have selected. In the option selected, the Tenant’s share and the current amount are indicated. Furthermore, indicate how the Tenant’s share is calculated. 
 [signature] [signature] 

 Page 1(1) 

 

 Value added tax clause 

Appendix no. 3 
  

					
	Concerning	  	 Lease agreement no.
  

4301-7804-00
	  	 Premises
  
 Hunnerup 1

			
	Landlord	  	I-Parken i Lund AB	  	 National ID/company registration no.
  

556263-8394

			
	Tenant	  	Novozymes Biopharma AB	  	 National ID/company registration no.
  

556627-0830

		
	 Appendix

/Addendum:
	  	 VAT clause
  

Article 1      Value added tax clause

 

a)      The Tenant shall conduct VAT-liable business on the premises, or
shall have the right to receive compensation (a ‘refund’) in pursuance of Chapter 10 of the Swedish VAT Act.
  

b)     The Tenant shall on each occasion in addition to the rent pay the VAT as
stipulated under currently applicable legislation in relation to Value Added Tax on rent. The VAT shall be paid at the same time as the rent, calculated on the amount of the rent and, where applicable, shall be calculated as per supplementary costs
such as (consumer price) index changes, gas/fuel, water supply and sewage, cooling, electricity, ventilation and property taxes, etc.
  

c)      The Tenant undertakes to inform the Landlord in the event of any
changes to the Tenant’s activity, which could involve the cessation of registration as a VAT-liable business. The change may be due to the Tenant’s activity being deemed no longer liable to Value Added Taxation by a tax or other authority,
or may be due to some other action by the Tenant, of whatever nature. In the event of the cessation of the Tenant’s registration as a VAT-liable business, or if the Tenant no longer has the right to a refund in pursuance of Chapter 10 of the
Swedish VAT Act, the Tenant shall provide compensation to the Landlord as stipulated below.
  

d)     The Tenant is not entitled to wholly or partly assign the leasing rights
to the premises to a third party (‘sublet the premises’) in the absence of the written consent of the Landlord. To the extent that the Tenant is allowed to sublet the premises in accordance with written permission from the Landlord
providing for such, or if the rent tribunal has given their permission for subletting of the premises, the Tenant shall be required to register this subletting activity for Value Added Tax so that the Landlord does not become liable to pay for a VAT
adjustment. As regards all subletting of the premises to a non-VAT-liable business, the Tenant shall provide compensation to the Landlord as stipulated below.
  

e)      The Tenant is not entitled to assign the leasing rights to the
premises to a third party without the written consent of the Landlord. If specific permission has been retained from the Landlord or the rent tribunal permitting the Tenant to assign the leasing rights to a non-VAT-liable business, the Tenant shall
provide compensation to the Landlord as stipulated below.
  
 The Tenant
shall compensate the Landlord on all occasions where the Tenant has caused the Landlord to become liable to a base VAT amount adjustment, in accordance with the following:

 

•      for the amount that the Landlord is obligated to pay for the concept of
an adjustment as provided for in Chapter 8(a) of the Swedish VAT Act (1994:200), on adjustments of deductions for base VAT amounts in respect of an investment item.
  

•      for the remainder of the lease period and at the same time as usual
rent payments, for the amount corresponding to the increased cost incurred by the Landlord as a consequence of the lost right of deduction on the base VAT amount.
  

If the Tenant, with or without the approval of the Landlord, undertakes new construction, extension or renovation work on the premises
during the rental period, the Tenant shall submit a written specification of the measures taken, as well as the amounts paid for said measures, to the Landlord. This is required because this evidence may be used as supporting documentation submitted
to substantiate a VAT adjustment in pursuance of Chapter 8(a)(2)(4) of the Swedish VAT Act (1994:200).

  

					
	Signature	  	Place/date	  	Place/date
			
		  	[hw:] Malmö 26/03/2009	  	

					
		  	Landlord	  	Tenant
			
		  	I-Parken i Lund AB	  	Novozymes Biopharma AB
			
		  	            [signature]                
    [signature]	  	[signature]
			
		  	[stamp:] Peter Olsson	  	[stamp:] Johan Sjöstedt

					
	 [logo]
	  	    LEASING AGREEMENT	  	Page 7(4)
	THE SWEDISH PROPERTY FEDERATION	  	FOR NON-RESIDENTIAL PREMISES	  	No. 33001 7724 07

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

 Special provisions 

Appendix No. 4 
  

					
	Concerning	  	 Lease agreement no.
  

4301-7804-00
	  	 Premises
  
 Hunnerup 1

			
	Landlord	  	I-Parken i Lund AB	  	 National ID/company registration no.
  

556263-8394

			
	Tenant	  	Novozymes Biopharma AB	  	 National ID/company registration no.
  

556627-0830

		
	 Appendix

/Addendum:
	  	 SB Storage Facilities
  

Article 1      The premises

 
 Irrespective of the design and condition of the premises, the
Landlord shall have the right to perform any changes justified on the basis of reasons related to the building construction or similar reasons invoked by a relevant authority. Such changes shall be done as per consultation and reasonable regard
shall be taken to the Tenant’s wishes before the choice of a technical solution is made.
  

Article 2      Parking spaces

 
 Can be let at Q-Park.

 

Article 3      Environmental responsibility

 
 If the Tenant engages in environmentally dangerous activity, the
Tenant shall inform the Landlord and if the Landlord so requests, shall allow for environmental inspections to be performed on the property and leased premises at his own cost.

 
 The environmental inspection shall be performed by a reputable
inspection company that has been approved by the Landlord. The results of the inspection shall be immediately provided to the Landlord.
  

If the Tenant conducts activity that leads to an injunction or decision in pursuance of The Swedish Environmental Code or other
environmental legislation, the Tenant shall be financially liable to the Landlord for all of his costs and damages incurred as a result of the conducted activity.
  

Article 4      Heating

 
 The cost of heating is not included in the rent and the Tenant
shall effect payment, as a supplement to the rent, for the amount of, at present, 130 Sq. m/year, which corresponds to the space units of the premises divided per Sq m of surface liable for debiting. A preliminary supplementary fee for 2008 shall be
paid in addition to the rent and shall be settled annually on the basis of the actual outcome drawn up by the Landlord.
  

At the time of settlement, the preliminary fee for the following year shall be determined. This cost shall be based
on

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 
  

					
	 License number: 2160-9981-2121-41. Version no. 6.5. Registered to: Sveareal AB
	  	Initial	  	Initial
		 	 
		  	[initialled]	  	 

					
		  	LEASING AGREEMENT    	  	Page 8(4)
		  	FOR NON-RESIDENTIAL PREMISES	  	No. 33001 7724 07

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

			
		 	 the previous year’s actual outcome.

 

Article 5      Water

 
 The cost of heating and water is not included in the rent and the
Tenant shall effect payment, as a supplement to the rent, for the amount of, at present, 20 Sq. m/year, which corresponds to the space units of the premises divided per Sq m of surface liable for debiting. A preliminary supplementary fee for 2008
shall be paid in addition to the rent and shall be settled annually on the basis of the actual outcome drawn up by the Landlord.
  

At the time of settlement, the preliminary fee for the following year shall be determined. This cost shall be     
based on the previous year’s actual outcome.
  
 Article 6      Electricity
  

The Tenant has their own contract with the provider.
  

Article 7      Maintenance, etc.

 
 The maintenance to be undertaken by the Tenant shall include
service and maintenance of doors.
  

Article 8      Disclosure obligation

 
 It is of essential importance to the Landlord that the Tenant
inform the Landlord in writing of any and each significant change to their activity and, in the event that the Tenant is a body corporate, of any change in ownership.
  

Article 9      Assignment of leasing rights

 
 Since the Landlord is registered as being liable to pay Value
Added Tax (‘VAT-liable’) in respect of renting the rental item, the Tenant is not entitled to wholly or partly assign the leasing rights to the premises to a third party that does not conduct VAT-liable business.

 
 Should the Tenant fail to comply with the above provision, the
Landlord shall be entitled to charge

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 
  

					
	Notice: This is a translation into English of form no. 12B	  	Initial	  	Initial
		 	 
	License number: 2160-3649-09. Version no. 6.5. Registered to: Kungsleden Fastighets AB.	  	[initialed]	  	 

					
		  	LEASING AGREEMENT    	  	Page 9(4)
		  	FOR NON-RESIDENTIAL PREMISES	  	No. 33001 7724 07

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

			
		  	 the Tenant for any and all costs that he might incur in relation thereto.

 

Article 10    Fixtures and fittings work etc.

 
 In the absence of written permission from the Landlord, the
Tenant shall not have the right to perform works related to renovations of the interior, fixtures and fittings, or other reconstruction works, either on the property or on the premises.

 

Article 11    Systematic Fire protection work

 
 It shall be incumbent upon the Tenant to, at his own cost and on
his own account, comply with all current requirements stipulated under the Swedish Civil Protection Act (2003:778) and related decrees, regulations and guidelines.
  

Escape routes may not be blocked.
  

Article 12    Professional membership where applicable

 
 The Tenant shall be under the obligation to be a member of the
professional association active on the given property, and to pay the relevant membership fee, as well as to comply with all decisions taken by this professional association.

 

Article 13    Surrender of the premises

 
 At the end of the lease, the Tenant is responsible for returning
the leased premises in a condition that is clean and in a generally acceptable condition. In the event that the premises are lacking in terms of cleanliness or maintenance, the Landlord shall be entitled to have the premises cleaned and/or repaired
at the Tenant’s cost.
  
 At the latest on the day of
the termination of the lease, the Tenant shall, at his own cost, remove all of his property such as goods, stocks, signs, etc. Property that has not been removed shall be considered abandoned and shall become the property of the Landlord, for which
compensation may not be claimed. The Landlord shall have the right, however, to demand that the Tenant proceed to remove waste, etc., or to have this done at the cost of the Tenant.

 
 No compensation shall be paid for changes, extensions or
renovations performed to the premises by the Tenant, unless agreed upon in writing, or following from Chapter 12 Sections 56-60 of the Swedish Land Code.
  

Article 14    Distribution of responsibility in respect of equipment containing
chlorofluorocarbons (CFCs)
  
 The Tenant shall be
responsible for, and where applicable, shall assume the Landlord’s responsibility to ensure that equipment containing CFCs used by the Tenant in their activity complies with all requirements stipulated under the Swedish Environmental Code, and
in ancillary legislation thereto.
  
 Inter alia, this
shall mean that, in pursuance of The Refrigerants Order, the Tenant shall be obligated to ensure compliance with all rules in respect of notification, annual inspection and reporting to authorities.

 
 The Tenant’s obligations shall include maintenance,
requisite exchange or new installation of equipment, etc. and notification.
  
 Article 15    Reduction of rent during normal maintenance
  

The Tenant shall have no right of reduction of the rent due to impediment or detriment of the right of use and enjoyment as a
consequence of the Landlord performing normal maintenance or renovation of the rented premises or other parts of the property. However, it shall be incumbent upon the Landlord to inform the Tenant well in advance about the type and scope of the work
and when and during which time the work will be performed. The Landlord shall minimize disruptions to the Tenant to the greatest possible extent during the execution of said measures.

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 
  

					
	Notice: This is a translation into English of form no. 12B	  	Initial	  	Initial
		 	 
	License number: 2160-3649-09. Version no. 6.5. Registered to: Kungsleden Fastighets AB.	  	(initialed)	  	 

					
		  	LEASING AGREEMENT    	  	Page 10(4)
		  	FOR NON-RESIDENTIAL PREMISES	  	No. 33001 7724 07

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

					
	 Signature
	 	 Place/date
  
 [hw:] Malmö 03/26/2009
	  	Place/date
			
		 	 Landlord
  
 I-Parken i Lund AB
  
 [signature]                        [signature]

 
 [stamp:] Peter Olsson
	  	 Tenant
  
 Novozymes Biopharma AB
  

[signature]

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 
  

					
	Notice: This is a translation into English of form no. 12B	  	Initial	  	Initial
		 	 
	License number: 2160-3649-09. Version no. 6.5. Registered to: Kungsleden Fastighets AB.	  	(initialed)	  	 

					
		  	LEASING AGREEMENT    	  	Page 11(4)
		  	  
 FOR NON-RESIDENTIAL PREMISES
	  	  

No. 33001 7724 07

 

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

																									
	  

Landlord
	 	  
 I-Parken i Lund
AB
	 	  
 National ID/company registration no.

	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	  
 556263-8394

	  
 Tenant
	 	  
 Novozymes
Biopharma AB
	 		 		 	 	 	  

National ID/company registration no.

	 											 
	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	556627-0830
	  

Tenant (2)
	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	  
 National ID/company registration no.

	  

Premise Address, etc.
	 	  
 Municipality
  

Lund
	 	  
 Property designation
  
 Hunnerup
1

	 	  
 Street address
  
 S.t Lars
Väg 49
	 	  
 Stairs/house
	 	  
 Apartment no.
  

	 	  
 Billing address:
  
 S:t Lars
väg 49, 220 07 LUND
	 	 	 	 	 	 	 	 
	  

Condition and use of the office space
	 	  
 Unless
otherwise indicated, the office space with associated facilities is being leased for use as:
	 	  
 Storage/Changing room

	  
 Size and extent of the office space
	 	  
 Shop
area
  
	 	  
 Office area in

 
	 		 	 	 	  

Storage area in
  
	 	  
 Other area

 
	 	 
	 	plan	 	  m2  	 	plan	 	   m2

 
   ca. 361  

 
  
	 	plan	 	  m2  	 	Plan	 	m2	 	plan	 	m2
	 	 	 	 
	 	 	  
 The indicated areas
  
  ̈  have    x  Have not        been measured jointly prior to the execution of
the Agreement
  
 Should the area shown in the Agreement deviate from that
actually measured, this does not entitle the Tenant to any repayment of rent nor entitle the Landlord to any increased rent
  
 x  The extent of the leased premises is marked on appended plan(s)
	 	  
 Appendix 5

	 	 	  
 access for cars loading and unloading
  
  ̈
	 	 place for sign

 
  ̈
	 	 place for display cabinet / vending
machine
  
  ̈
	 	 parking space(s) for

 

 ̈        car(s)
	 	 garage space(s) for cars

 
  ̈
	 	 ̈

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 
  

					
	Notice: This is a translation into English of form no. 12B	  	Initial	  	Initial
		 	 
	License number: 2160-3649-09. Version no. 6.5. Registered to: Kungsleden Fastighets AB.	  	[initialed]	  	 

					
		  	LEASING AGREEMENT    	  	Page 12(4)
		  	  
 FOR NON-RESIDENTIAL PREMISES
	  	  

No. 33001 7724 07

 

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

							
	Furnishings, etc.	  	The premises are let	  		  	Appendix
				
		  	 x  without furnishings

 
 specific to the Tenant’s use of the premises
	  	  ̈  with furnishings/fixtures/fittings

 
 specific to Tenant’s use of the premises according to
appendix
	  	
		  	  
 Unless otherwise agreed upon, at the termination of
the tenancy, the Tenant shall remove all property belonging to him and surrender the premises in acceptable condition.
  
 The parties agree to carry out a joint inspection of the premises not later than the last day of the tenancy. If, as a result of the Tenant’s actions – carried out with or without the
Landlord’s consent – the premises upon surrender should contain material, which had not previously been agreed that the Landlord should be responsible for, the Tenant shall remove such material or pay the Landlord’s expenses in so
doing, including but not limited to, transportation costs, waste disposal taxes and storage charges.

			
	Telephone lines	  	x  The Tenant shall pay for the installation of the necessary telephone lines from a connection point
designated by the service provider to those points in the premises chosen by the Tenant in consultation with the Landlord.	  	
			
		  	 ̈  The Landlord shall pay for the corresponding installation of lines to the premises. The installation of the
lines inside the premises shall be carried out by the Tenant in consultation with the Landlord; the cost, however, to be borne by the Tenant.	  	
			
	Data communication lines	  	x  The Tenant shall pay for the installation of the necessary data communication lines from a connection point
designated by the service provider to those points in the premises chosen by the Tenant in consultation with the Landlord.	  	
			
		  	 ̈  The Landlord shall pay for corresponding installation of lines to the premises. The installation of lines
inside the premises shall be carried out by the Tenant in consultation with the Landlord; the cost, however, to be borne by the Tenant.	  	
			
	Term of lease	  	 Commencing 
  
 04/01/2008 
	  	 Up to and including
  

03/31/2013

		
	Termination/extension	  	 Notice of termination of this Agreement must be given in writing at least 9 months prior to the expiry of this
Agreement.
  
 In the absence thereof, this Agreement is extended by a term of
3 years at a time.

			
	Heating and hot water	  	 Requisite heating of the premises is provided by 
  

Hot water is provided    x  throughout the year 
	  	 x  the
Landlord                             ̈  the
Tenant
  
  ̈  not
provided                 ̈

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 
  

					
	Notice: This is a translation into English of form no. 12B	  	Initial	  	Initial
		 	 
	License number: 2160-3649-09. Version no. 6.5. Registered to: Kungsleden Fastighets AB.	  	[initialed]	  	 

					
		  	LEASING AGREEMENT    	  	Page 13(4)
		  	  
 FOR NON-RESIDENTIAL PREMISES
	  	  

No. 33001 7724 07

 

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

									
	Rent	  	 SEK
  

400,000                    Per annum comprising  ̈ total rent x rent excl. supplements marked Appendix

			
	Index clause	  	x Changes to the above-stated rent shall be effected pursuant to the appended index clause	  	App. 1
			
	Heating and hot water costs	  	x Fuel/heating supplement payable in accordance with appended clause Special provisions	  	App 4
			
	Water and sewerage costs	  	 ̈ Water/sewerage supplement payable in accordance with appended clause	  	App
			
	Cooling Ventilation	  	 ̈ Costs for the operation of special cooling and ventilation appliances shall be reimbursed in accordance with appended
clause	  	App.
				
	Electricity	  	 ̈ included in rent	  	x Tenant has own contract with the provider	  	
				
	Cleaning of stairwell	  	x included in rent	  	 ̈ arranged for and paid for by the Tenant	  	
		
	Refuse and waste removal	  	 Insofar as the Landlord is responsible for the provision of storage space for refuse/waste, and arranging for the removal of
such refuse/waste, it is the Tenant’s responsibility to sort and deposit refuse/waste in the appropriate containers as directed, in their designated place, as well as without recompense contribute towards further and/or additional sorting, as
directed by the Landlord.
  
 Refuse and waste removal

 
  ̈ included in rent

 
  ̈ arranged for and paid for by the
Tenant
  
 x included in rent
with respect to the types of refuse/waste indicated below. The Tenant shall be responsible for, and pay for the costs of, collection, sorting, storage and transportation of the categories of refuse/waste not indicated below which are to be found on
the Tenants premises.

		  	  
 x household
waste
  
  ̈ heavy
refuse
  
  ̈ compostable
waste
  
  ̈
newspapers
  
  ̈
batteries
	  	  
  ̈ fluorescent
tubes
  
  ̈ metal
packaging
  
  ̈ clear glass
containers
  
  ̈ colored glass
containers
  
  ̈ cardboard
packaging
	  	  
  ̈ hard
plastic packaging
  
  ̈
Hazardous waste pursuant to the Hazardous Waste Ordinance (1996:971)
  
  ̈                                  
              
  
  ̈                         
                       
  

 ̈                 
                               

	  
 Snow clearance and gritting
	  	x included in rent         ̈ to
be arranged for and paid by the Tenant          ̈as per App.	  	App.

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 
  

					
	Notice: This is a translation into English of form no. 12B	  	Initial	  	Initial
		 	 
	License number: 2160-3649-09. Version no. 6.5. Registered to: Kungsleden Fastighets AB.	  	[initialed]	  	 

					
		  	LEASING AGREEMENT    	  	Page 14(4)
			
		  	FOR NON-RESIDENTIAL PREMISES	  	No. 33001 7724 07

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

					
	Property taxes	  	  ̈ included in
rent            x reimbursement payable as per special agreement
	  	App. 2            
		
	Unforeseen costs	  	 Where, following the execution of this Agreement, unforeseen increases in costs arise in relation to the property as a
consequence of:
  

c)      the introduction of, or increase in taxes, charges or duties levied
specifically on the property as a result of decisions taken by the Parliament, Government, municipalities, or other relevant authorities;
  

d)      general rebuilding measures or suchlike in respect of the property which do
not relate solely to the premises and which the Landlord is obliged to execute as a result of decisions of the Parliament, Government, municipalities or other relevant authorities;

 
 The Tenant shall, commencing at the time of the cost increase, reimburse the Landlord
in relation to that proportion of the total annual increase in costs for the property represented by the premises.
  
 The proportion represented by the premises is 1.75 percent. Where the proportion has not been indicated, it shall be comprised of that proportion of the total rents for premises (excluding any
value-added tax) represented by the Tenant’s rent (excluding any value-added tax) at the time of the increase in costs. For unleased premises, the market rent for the premises shall be estimated.

 
 ‘Taxes’ in accordance with a) above does not refer to value-added tax and
property tax to the extent that reimbursement in respect of this is paid as per agreement. ‘Unforeseen costs’ means such costs as were not decided upon by the authorities as set forth in sections a) and b) at the inception of the
Agreement. Reimbursement shall be paid in the same manner as set forth below for rental payments.

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 
  

					
	Notice: This is a translation into English of form no. 12B	  	Initial	  	Initial
		 	 
	License number: 2160-3649-09. Version no. 6.5. Registered to: Kungsleden Fastighets AB.	  	[initialed]	  	 

					
		  	LEASING AGREEMENT    	  	Page 15(4)
			
		  	FOR NON-RESIDENTIAL PREMISES	  	No. 33001 7724 07

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

									
	Value-added tax (VAT)	  	 x The property owner/Landlord is liable to pay value-added tax for the
letting of the premises. In addition to rent, the Tenant shall on each occasion pay the VAT currently applicable.
  
  ̈ Where, following a decision by the Tax Authorities, the property owner/Landlord becomes liable to pay VAT for the letting of the premises, the Tenant
shall on each occasion in addition to the rent pay the VAT currently applicable.
  
 The VAT paid together rent shall be calculated on the stated rental amount and where applicable on supplemental charges and other reimbursements paid in accordance with the Agreement, pursuant to the
rules applicable at the time in respect of VAT payable on rent.
  
 Where the
Landlord becomes liable to pay VAT pursuant to the provisions of the Value Added Tax Act as a consequence of the Tenant’s independent actions, such as a subletting of the premises (including subletting to its own company) or assignment, the
Tenant shall reimburse the Landlord in full. In addition, the Tenant shall reimburse the Landlord in respect of the increased costs arising as a consequence of the Landlord’s loss of the entitlement to deduct VAT on operating expenses incurred
as a consequence of the Tenant’s actions.

		
	Payment of rent	  	The rent shall be paid in advance without prior demand, not later than the last Postal giro no.             
Bank giro no.              working day prior to the commencement of
				
		  	  ̈ each calendar month        x each quarter
	  	 by direct transfer to either of
 the following accounts
	  	5674-6373
		
	Interest, Payment reminders	  	Upon delay in the payment of rent, the Tenant shall pay interest in accordance with the Interest Act as well as compensation for written payment reminders in accordance
with the Debt Recovery Act, etc. Compensation for payment reminders shall on each occasion be paid in an amount currently applicable pursuant to the Debt Recovery Ordinance, etc.
				
	Maintenance, etc.	  	 ̈ The Landlord shall carry out and bear the cost of necessary maintenance of the premises and furnishings/fittings/fixtures supplied
by him. 	  	However, the Tenant shall be responsible for	  	Appendix            
				
		  	x The Tenant shall carry out and bear the cost of necessary maintenance of the surface of floors, walls and ceiling, as well as of
furnishings/fittings/fixtures provided by the Landlord.	  	 The Tenant’s maintenance obligation includes
	  	Appendix
		
		  	Where the Tenant does not fulfill his maintenance obligations and does not within a reasonable time carry out rectification works following a written demand, then the
Landlord shall be entitled to fulfill these obligations at the Tenant’s expense.

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 
  

					
	Notice: This is a translation into English of form no. 12B	  	Initial	  	Initial
		 	 
	License number: 2160-3649-09. Version no. 6.5. Registered to: Kungsleden Fastighets AB.	  	[initialed]	  	 

					
		  	LEASING AGREEMENT        	  	Page 16(4)
			
		  	FOR NON-RESIDENTIAL PREMISES    	  	No. 33001 7724 07

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

							
		  	 ̈	 	 The allocation of the maintenance obligations is set forth as per separate appendix. 
	  	Appendix
		
	Management and operation	  	 Unless otherwise agreed, the Landlord shall, where applicable, manage, operate, and maintain the public and common
areas.
  
 The Tenant shall be entitled, without the Landlord’s written
consent, to carry out any fitting and/or installation or alteration works within the premises or otherwise within the property, which directly affects the structural components of the building or installations important to the functioning of the
property, such as water and sewage, electricity, ventilation systems, etc., which are the property of the Landlord.
  
 Sprinkler heads and ventilation equipment may not be covered by any fixtures/fittings by the Tenant in such a manner as to reduce the functioning of such equipment. In conjunction with the performance of
fitting out works, the Tenant shall ensure that the functioning of radiators and other heating equipment is maintained in all significant respects.

		
	Inspections	  	Where any defects and/or deficiencies are found subsequent to an inspection by a relevant authority, in the electrical and sprinkler equipment is the property of the
Tenant, the Tenant shall, at his own cost and within the period prescribed by the relevant authority, carry out any measures required. Where the Tenant has not rectified the defects and/or deficiencies within the stated time, the Landlord shall be
entitled, at the Tenant’s expense, to carry out such measures as are required by the relevant authority.
		
	Access to certain spaces	  	The Tenant shall keep areas to which the maintenance to personnel and personnel from the energy utilities, water and sewage utilities, the telephone company, and any
like organization must have access to, easily accessible by keeping such areas free of cupboards, crates, goods, or any other obstruction.
		
	Building material specifications	  	Whether, pursuant to the provisions of this Agreement or otherwise, the Tenant performs maintenance, improvement, or alteration works in respect of the premises, the
Tenant shall provide the Landlord, in good time prior to the execution of such work, with specification of the building materials – to the extent such have been prepared – for the products and materials to be used on the
premises.
		
	Planning and Building Code (PBL) fines	  	When the Tenant undertakes alterations to the premises without the requisite construction permit and, as a consequence thereof the Landlord is compelled to pay
construction fines or supplemental fees pursuant to the rules set forth in the Planning and Building Code (PBL), the Tenant shall reimburse the Landlord in respect of this.
		
	Reduction of rent	  	The Tenant shall not be entitled to a reduction in rent for the period during which the Landlord allows work to be carried out in order to place the premises in the
agreed condition, or other works specifically set forth in the Agreement.
				
		  	 ̈	 	 The Tenant’s right to a reduction in rent during the Landlord’s performance of customary 
	  	Appendix

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 
  

					
	Notice: This is a translation into English of form no. 12B	  	Initial	  	Initial
		 	 
	License number: 2160-3649-09. Version no. 6.5. Registered to: Kungsleden Fastighets AB.	  	[initialed]	  	 

					
		  	LEASING AGREEMENT    	  	Page 17(4)
			
		  	FOR NON-RESIDENTIAL PREMISES	  	No. 33001 7724 07

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

							
		  	maintenance of the leased premises or the property shall be governed by a separate appendix.
				
	Requirement imposed by relevant authorities, etc.	  	 ̈ The Landlord	  	x The Tenant	  	
	  	  
 shall be solely responsible for, and bear the cost of,
undertaking measures which may be required for the intended use of the premises by insurance companies, building authorities, environmental or health authorities, fire departments, or other relevant authorities after the date of taking possession.
The Tenant shall consult with the Landlord prior to undertaking any such measures.

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 
  

					
	Notice: This is a translation into English of form no. 12B	  	Initial	  	Initial
		 	 
	License number: 2160-3649-09. Version no. 6.5. Registered to: Kungsleden Fastighets AB.	  	[initialed]	  	 

					
		  	LEASING AGREEMENT    	  	Page 18(4)
			
		  	FOR NON-RESIDENTIAL PREMISES	  	No. 33001 7724 07

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

							
	Signs, awnings, windows, doors, etc.	  	 Following consultation with the Landlord, the Tenant shall be entitled to display a customary business sign, provided that
the Landlord has not reasonably denied the same and that the Tenant has obtained the requisite permit from the relevant authority. Upon surrender of the premises, the Tenant shall restore the facade of the building to an acceptable
condition.
  
 In conjunction with more extensive property maintenance, such
as the renovation of facades, etc, the Tenant shall, at his own cost and without compensation, dismantle and reassemble signs, awnings, and antennas.
  

The Landlord undertakes not to fix vending machines and display cabinets on the exterior walls of the premises let to the Tenant without the Tenant’s
consent, and grants to the Tenant an option to fix vending machines and display cabinets on the walls in question.

		
		  	  ̈ The Landlord
 x The Tenant is liable for any damage due to negligence or malicious intent to

		  		  	             x
windows     x display/shop windows        x entrance doors

            x
signs           x Damage due to breaking/entering/robbery

		
		  	x The Tenant shall purchase and maintain glass insurance with respect to all display/shop windows and entrance doors
appurtenant to the premises.
			
	Locks	  	  ̈ The Landlord 
	  	x The Tenant shall equip the premises with such locks and anti-theft devices as may be required to ensure the validity of
the Tenant’s business insurance.
		
	Force majeure	  	The Landlord shall not be compelled to perform his obligations under this Agreement or pay any damages where, as a consequence of acts of war or riots, work stoppages,
blockades, fires, explosions, or intervention by a public authority over which the Landlord has no control and which could not have been foreseen, and the Landlord is prevented entirely from performing his obligations or may only be able to do so at
abnormally high cost.
			
	Security	  	 This Agreement is contingent upon the provision of security in the form of a

 
  ̈ Bank
guarantee         ̈ Personal
guarantee         ̈      To be provided no later than 
	  	Appendix
			
	Special provisions	  	  

-        Value added tax clause

-        Special provisions
	  	 Appendix
 3

4

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 
  

					
	Notice: This is a translation into English of form no. 12B	  	Initial	  	Initial
		 	 
	License number: 2160-3649-09. Version no. 6.5. Registered to: Kungsleden Fastighets AB.	  	[initialed]	  	 

					
		  	 LEASING AGREEMENT    

 
	  	 Page 19(4)
  

		  	FOR NON-RESIDENTIAL PREMISES	  	No. 33001 7724 07

  

			
	The undersigned have this day entered into the following Lease Agreement:	  	An X in a box means that the text following thereafter applies

  

									
	Signature	  	This Agreement, which may not be registered without specific consent, has been prepared in two identical copies of which each party has received one. All prior
agreements between the parties with respect to these premises shall cease to apply commencing on the date of the execution of this Agreement.
			
		  	 Place/date
 [hw:]
080317
	  	 Place/date
 [hw:]
080313

			
		  	 Landlord
 I-Parken
i Lund AB
 [signature]
	  	 Tenant
 Novozymes
Biopharma AB
 [signature]

			
		  	 Printed name

[stamp:] Peter Olsson [stamp:] Johan Sjöstedt
	  	 Printed name
 [hw:]
[illegible]

									
		
	Agreement with respect to the surrender of the premises	  	As a consequence of an agreement entered into on this day, the Agreement shall cease to apply commencing
                                         at which
time the Tenant undertakes to surrender the premises.
	  	  
 Place/date
	  	  
 Place/date

	  	  
 Landlord
	  	  
 Tenant

		
	Assignment	  	This Lease Agreement is hereby assigned
to                         commencing
                        
	  	  
 Assignor
	  	  
 Assignee (New Tenant)
	  	  
 National ID/co. registration no.

			
	The above referenced assignment is hereby approved	  	Place/date	  	Landlord

  
 Notice 

Note that in certain cases, in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in
such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s right to a reduction of rent in conjunction with customary maintenance. 

In addition, see Instructions prepared by the organizations. 
  

 
 Swedish Property Federation form no. 12B,
prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels- and Restaurants Association (SHR). Copying prohibited. 
  

					
	Notice: This is a translation into English of form no. 12B	  	Initial	  	Initial
		 	 
	License number: 2160-3649-09. Version no. 6.5. Registered to: Kungsleden Fastighets AB.	  	[initialed]	  	 

							
	[logo]	  		  	INDEX CLAUSE	  	Page 1 (2)
		
	THE SWEDISH PROPERTY FEDERATION	  	FOR NON-RESIDENTIAL PREMISES

  

 Appendix no. 2 

 

					
	Concerns	  	 Lease contract no.
  

33001 7724 07
	  	 for the property
  

Hunnerup 1

		
	Landlord	  	I-Parken i Lund AB, 556263-8394
		
	Tenant	  	Novozymes Biopharma AB, 556627-0830
		
	Clause	  	 The applicable option is marked with a cross in the box and filled in with the required information.

 
 To the extent that the portions of the property that consist of the office space
should be/are liable to property taxes, the Tenant shall pay the Landlord compensation for this along with the rent, according to the marked option.
  

x In addition to the rent amount specified in the contract, the Tenant shall annually pay for compensation
for his share of outgoing property taxes for the office space on each occasion. The Tenant’s share shall be considered to be 1.75 percent.
  

According to the rules that apply at the time of the signing of the contract, the compensation constitutes 30,620 SEK per year at the start of the lease
period.
  
  ̈ Compensation for
the share of the property taxes accruing at the office space is included in the rent amount specified in the agreement and constitutes                  SEK at the time
of the signing of the agreement.
  
 The office space’s share of the
property taxes for the office space shall be considered to be          percent. The Tenant shall pay compensation for his share of changes that occurred (regardless of the reason for them) in the property
taxes for the office space, after the signing of the agreement, to the extent that the taxes exceed the compensation for the property taxes that is included in the rent.
  

If the property taxes should happen to decrease/cease, with the result that the Tenant’s share of the compensation is less than the compensation that
is included in the rent specified in the agreement, in accordance with the above, however, the rent shall at least amount to the original amount. Other clauses (e.g. index) found in the agreement thus entail that the total rent amount that the
Tenant pays is/may be higher than the rent sum specified in the agreement.
  

The Tenant’s share specified above, which shall be unaltered during the rental period, has been calculated according to the
following:

 Swedish Property Federation form no. 7B, prepared in 1995. Point 21. Guidelines revised in 1997. 

Copying prohibited. 
 Lic. no.:
2160-9981-2121-41. Version no.: 6.5 Licensed to: Sveareal AB 

					
		  	The instructions on page 2 are applicable to the agreement.
			
	Signature	  	 Place/date
  

[handwritten:] 080317
	  	 Place/date
  

[handwritten:] 080317

			
		  	 Landlord
  
 I-Parken i Lund AB
  

[signature] [signature]
	  	 Tenant
  
 Novozymes Biopharma AB
  

[signature]

			
		  	 Printed name
  

[stamp:] Peter Olsson [stamp:] Johan Sjöstedt
	  	 Printed name
  

[hw:] [illegible]

			
	INSTRUCTIONS	  	Page 2(2)

  

 1. 
 The clause was formulated in June 1995, i.e. before the time (usually January 1, 1996) from which the property taxes apply for the office space. The clause therefore has a wording that means that
this can be introduced into the agreement that is signed before the taxes are paid, as well as in the agreement that is signed when the taxes are actually paid. 
 2. 
 The compensation shall compensate for increased administrative costs, regardless of who
is actually liable for tax. Property owners / Landlords are liable for tax. If partnerships are property owners / Landlords, according to previous rules, shareholders are liable for tax. The rent supplement would of course yet be paid to the
Landlord. After January 1, 1997, however, partnerships, as owners, are liable for property taxes. 
 3. 

According to § 19 of the Rent Act, the rent – with some exceptions – shall be the amount determined in the rent agreement. If the lease
period is specified, and for a period of at least three years, reservations also apply that the rent shall be paid in the amount determined according to “another basis for calculation,” e.g. adjustment of the index. This also means that
the lease term must be determined at least three years before the Landlord shall be able to charge compensation for property taxes, with an amount that can vary according to the change in the tax. Furthermore, the basis for calculation must be
specified in the agreement. The clause therefore assumes that the parties will indicate for how large a share of the tax the Tenant must pay compensation. 
 According to the rules that are applicable at the time of this clause’s preparation, the tax constitutes a certain percent of the assessment value for the office space (both land and buildings). The
declaration is reported in the tax information. The Tenant’s share of the tax for the office space can be determined as the relationship between the area that the Tenant rents and the rentable area of the property, or as the relationship
between the Tenant’s rent and the total rents on the property. 
 What rate of calculation the parties select becomes a
matter for negotiation. Other bases for calculation can also be used. For the sake of simplicity, however, the Tenant’s share should be unchanged during the lease term and, thus, independent of, for example, how the taxes can continue to be
calculated, and any changes in the position of the rent. 
 It is appropriate, therefore, to indicate at the intended place how
the office space’s share has been calculated. If the information relating to this should happen not to be filled in, this shall not mean, however, that the agreement becomes invalid. On a property, various buildings can be found with various
values and various types of assessable units (single-family home, apartment building, industrial facility, and special unit). The tax – for which the Tenant shall pay compensation – shall only relate to the building where the office space
is located. A building usually refers to each structural body. Required information can be retrieved from the notification of the decision about general property assessment which the Tax Agency sends to the property owner. The property owner who has
problems calculating the Tenant’s share should contact his property owner’s association for assistance. 

 Fill in the Tenant’s share! 
 4. 
 The clause contains two options. In the first, compensation is paid for tax as a rent
supplement “alongside” the rent amount specified in the agreement. The tax and the rent supplement disappear automatically. The other option assumes that the parties are in agreement about a certain rent in which, for instance,
compensation for the applicable tax is included. If the tax should happen to be raised, regardless of the reason (e.g. high tax rate, increased tax assessment value, etc.) the Tenant shall nevertheless pay compensation for the increased cost. If the
tax should happen to disappear, the rent returns to the original amount, i.e. the agreed upon rent (which includes compensation for the initially applicable tax which ceased). Naturally the Tenant shall still pay other rent supplements that occur,
such as for changes in the index, changes in fuel costs, etc. 
 5. 
 To the extent that the Tenant shall pay a rent supplement for property taxes, the rent supplement should be reported separately on the rent specification. 

6. 
 Mark with cross the option which you
have selected. In the option selected, the Tenant’s share and the current amount are indicated. Furthermore, indicate how the Tenant’s share is calculated. 

							
	[logo]	  		  	 INDEX CLAUSE
  
	  	 Page 1(2)
  

	THE SWEDISH PROPERTY FEDERATION	  	FOR NON-RESIDENTIAL PREMISES

  

 Appendix no. 1 

 

							
	Concerns	  	 Lease contract no.
 33001
7724 07
	  	in the property
 Hunnerup 1

		
	Landlord	  	I-Parken i Lund AB, 556263-8394
		
	Tenant	  	Novozymes Biopharma AB, 556627-0830
		
	Clause	  	 Of the rent amount specified in the contract, 400,000 SEK, 100% or 400,000 SEK shall constitute the
base rent. During the lease period, an addition to the rent amount shall be paid with respect to changes in the consumer price index (total index with 1980 as the base year), with a certain percent of the base rent, according to the reasons
below.
  

•      For lease agreements that begin at any time during the period 01/01
– 06/30, the base rent is adjusted to the index value for October of the previous year.
  

•      For lease agreements that begin at any time during the period 07/01
– 12/31, the base rent is instead adjusted to the index value for October of the same period.
  

•      The index value for October, to which the base rent is considered to
be adjusted in accordance with the above, constitutes the base number unless otherwise agreed upon as follows by indicating the year. Otherwise agreed upon base number, namely the index value for October 2007.

 
 If the index value should rise in relation to the base number in any subsequent
October, an addition shall be paid with the percentage by which the index value is changed in relation to the base number. In the continuation, the addition shall be paid in relation to the index changes, whereby the change in rent is calculated on
the basis of the percent change between the base number and the index number for the respective October.
  
 Outgoing rent, however, shall never be set lower than the rent amount specified in the contract. The change in rent always occurs as of January 1 after the October index occasions the
recalculation.
  
 The instructions on page 2 are applicable to this
agreement.

			
	Signature	  	 Place/date

[handwritten:] Malmö 080317
	  	 Place/date
 [handwritten:]
080313

 Swedish Property Federation form no. 6E, prepared in 1999 in consultation with the Swedish Federation of Trade and the
Swedish Hotels- and Restaurants Association (SHR). 
 The examples in the manual were revised in May 2002. Copying prohibited.

 Lic. no. 2160-9981-2121-41. Version no.: 6.5 Licensed to: Svereal AB 

					
		  	 Landlord
 I-Parken i Lund
AB
	  	 Tenant
 Novozymes Biopharma
AB

			
		  		  	Printed name
			
		  	[signature]	  	 Tenant

[signature]

			
		  	 Printed name
 Peter Olsson /
Johan Sjöstedt
	  	 Printed name
 [handwritten:]
[illegible]

 The Landlord’s own entry on base number: 293.85 

 Page 2(2) 

 

 Instructions for the Index Clause for Non-Residential Premises 

The Base Rent 

Whether the whole or some part of the rent amount specified in this agreement should constitute the base rent is a matter for
negotiation, and may otherwise depend on the lease terms (such as, for example, the rent’s size in
SEK/m2 and the year, as well as the other obligations that
are incumbent upon the Tenant, etc.). 
 The Base Number 
 The index number for October, to which the base rent is considered to be adjusted, makes up the base number unless otherwise indicated by indicating the year (see the provisions on page 1). 

A comparison of indices occurs as soon as the year’s October index is published. In recent years, the October index has been published in
mid-November. 
 Calculation of the rent supplement 
  

	 	10)	Calculate the difference between the current October index and the base number. 

 

	 	11)	If the difference is positive, the calculated difference is divided by the base number. 

 

	 	12)	The size of the rent supplement is calculated by this quotient, multiplied by the base rent. 

 Example 
 Calculation of rent supplement for the year 2002 

The base rent is assumed to be 100,000 SEK/year and is adjusted to the consumer price index (CPI) for October 1999, which is 259.7 (Base number). The
October index for the year 2001 is 269.1. 
  

	 	7.	Calculate the difference between the index number 269.1 and 259.7. The difference is positive and adds up to 9.4. 

 

	 	8.	Divide 9.4 by 259.7 and multiply the quotient (without rounding) by the base rent 100,000 SEK. The result is 3,619.56 SEK and constitutes the rent supplement for the
year 2002 according to the clause. 

 Alternative A: If the CPI for October 2001 should instead end up being lower than the
year before, e.g. 262.0 (October index for year 2000 was 262.6). 
 The difference between the assumed 262.0 and the base number 259.7 would
still have been positive and added up to 2.3. The quotient between 2.3 and the base number 259.7, multiplied by the base rent 100,000 SEK would have resulted in a rent supplement of 885.63 SEK. The total rent, however, would have been lower than for
the year 2001. 

 Alternative B: If the CPI for October 2001 should instead end up being lower than the base number 259.7,
e.g. 259.5. 
 The difference between 259.5 and the base number 259.7 would have then been negative. No rent supplement should then be paid.
The rent amount specified in the agreement should apply. 

 Page 1(1) 

 

 Value added tax clause 

Appendix no. 3 
  

					
	Concerning	  	 Lease agreement no.
 33001 7724
07
	  	 Premises
 Hunnerup
1

			
	Landlord	  	I-Parken i Lund AB	  	 National ID/company registration no.
 556263-8394

			
	Tenant	  	Novozymes Biopharma AB	  	 National ID/company registration no.
 556627-0830

		
	 Appendix

/Addendum:
	  	 VAT clause
  

Article 1 Value added tax clause
  

f)      The Tenant shall conduct VAT-liable business on the premises, or
shall have the right to receive compensation (a ‘refund’) in pursuance of Chapter 10 of the Swedish VAT Act.
  

g)      The Tenant shall on each occasion in addition to the rent pay the
VAT as stipulated under currently applicable legislation in relation to Value Added Tax on rent. The VAT shall be paid at the same time as the rent, calculated on the amount of the rent and, where applicable, shall be calculated as per supplementary
costs such as (consumer price) index changes, gas/fuel, water supply and sewage, cooling, electricity, ventilation and property taxes, etc.
  

h)     The Tenant undertakes to inform the Landlord in the event of any changes
to the Tenant’s activity, which could involve the cessation of registration as a VAT-liable business. The change may be due to the Tenant’s activity being deemed no longer liable to Value Added Taxation by a tax or other authority, or may
be due to some other action by the Tenant, of whatever nature. In the event of the cessation of the Tenant’s registration as a VAT-liable business, or if the Tenant no longer has the right to a refund in pursuance of Chapter 10 of the Swedish
VAT Act, the Tenant shall provide compensation to the Landlord as stipulated below.
  
 i)       The Tenant is not entitled to wholly or partly assign the leasing rights to the premises to a third party (‘sublet the premises’) in the
absence of the written consent of the Landlord. To the extent that the Tenant is allowed to sublet the premises in accordance with written permission from the Landlord providing for such, or if the rent tribunal has given their permission for
subletting of the premises, the Tenant shall be required to register this subletting activity for Value Added Tax so that the Landlord does not become liable to pay for a VAT adjustment. As regards all subletting of the premises to a non-VAT-liable
business, the Tenant shall provide compensation to the Landlord as stipulated below.
  

j)      The Tenant is not entitled to assign the leasing rights to the
premises to a third party without the written consent of the Landlord. If specific permission has been retained from the Landlord or the rent tribunal permitting the Tenant to assign the leasing rights to a non-VAT-liable business, the Tenant shall
provide compensation to the Landlord as stipulated below.
  
 The Tenant
shall compensate the Landlord on all occasions where the Tenant has caused the Landlord to become liable to a base VAT amount adjustment, in accordance with the following:

 

•      for the amount that the Landlord is obligated to pay for the concept of
an adjustment as provided for in Chapter 8(a) of the Swedish VAT Act (1994:200), on adjustments of deductions for base VAT amounts in respect of an investment item.
  

•      for the remainder of the lease period and at the same time as usual
rent payments, for the amount corresponding to the increased cost incurred by the Landlord as a consequence of the lost right of deduction on the base VAT amount.
  

If the Tenant, with or without the approval of the Landlord, undertakes new construction, extension or renovation work on the premises during the rental
period, the Tenant shall submit a written specification of the measures taken, as well as the amounts paid for said measures, to the Landlord. This is required because this evidence may be used as supporting documentation submitted to substantiate a
VAT adjustment in pursuance of Chapter 8(a)(2)(4) of the Swedish VAT Act (1994:200).

  

					
	 Signature
	 	 Place/date
 [hw:]
080317
	  	 Place/date
 [hw:]
080313

					
		 	 Landlord
 I-Parken i Lund
AB
  
 [signature]
                             [signature]

 
 [stamp:] Peter Olsson
	  	 Tenant
 Novozymes Biopharma
AB
  
 [signature]

 
 [stamp:] Johan Sjöstedt

 Page 1(2) 

 

 Special provisions 

Appendix No. 4 
  

					
	Concerning	  	 Lease agreement no.
 33001 7724
07
	  	 Premises
 Hunnerup
1

			
	Landlord	  	I-Parken i Lund AB	  	 National ID/company registration no.
 556263-8394

			
	Tenant	  	Novozymes Biopharma AB	  	 National ID/company registration no.
 556627-0830

		
	 Appendix

/Addendum:
	  	 Special provisions: non-residential premises

 

Article 1      The premises

 
 The Landlord will execute and pay for the
installation of parquet flooring on floor 2 (approx. 126 Sq. m).
  
 Irrespective of the design and condition of the premises, the Landlord shall have the right to perform any changes justified on the basis of reasons related to the building construction or similar reasons
invoked by a relevant authority. Such changes shall be done as per consultation and reasonable regard shall be taken to the Tenant’s wishes before the choice of a technical solution is made.

 

Article 2      Heating and water

 
 The cost of heating and water is not included in the rent and the
Tenant shall effect payment, as a supplement to the rent, for the sum amounting to the space units of the premises divided per Sq m of surface liable for debiting (SEK 118/Sq m/year). A preliminary supplementary fee shall be paid in addition to the
rent and shall be adjusted annually on the basis of the actual outcome.
  
 At the time of settlement, the preliminary fee for the following year shall be determined. This cost shall be based on the previous year’s actual outcome.

 

Article 3      Electricity

 
 The Tenant has their own contract with the provider.

 

Article 4      Disclosure obligation

 
 It is of essential importance to the Landlord that the Tenant
inform the Landlord in writing of any and each significant change to their activity and, in the event that the Tenant is a body corporate, of any change in ownership.
  

Article 5      Assignment of leasing rights

 
 Since the Landlord is registered as being liable to pay Value
Added Tax (‘VAT-liable’) in respect of renting the rental item, the Tenant is not entitled to wholly or partly assign the leasing rights to the premises to a third party that does not conduct VAT-liable business.

 
 Should the Tenant fail to comply with the above provision, the
Landlord shall be entitled to charge the Tenant for any and all costs that he might incur in relation thereto.
  

Article 6      Environmental responsibility

 
 If the Tenant engages in environmentally dangerous activity, the
Tenant shall inform the Landlord and if the Landlord so requests, shall allow for environmental inspections to be performed on the property and leased premises at his own cost.

 
 The environmental inspection shall be performed by a reputable
inspection company that has been approved by the

 [initialed]
[initialed] 

 Page 2(2) 

 

					
		  	 Landlord. The results of the inspection shall be immediately provided to the Landlord.

 
 If the Tenant conducts activity that leads to an injunction or
decision in pursuance of The Swedish Environmental Code or other environmental legislation, the Tenant shall be financially liable to the Landlord for all of his costs and damages incurred as a result of the conducted activity.

 

Article 7      Fixtures and fittings work etc.

 
 In the absence of written permission from the Landlord, the
Tenant shall not have the right to perform works related to renovations of the interior, fixtures and fittings, or other reconstruction works, either on the property or on the premises.

 Page 3(2) 

 

					
		  	 Article 8      Systematic Fire protection
work
  
 It shall be incumbent upon the Tenant to, at
his own cost and on his own account, comply with all current requirements stipulated under the Swedish Civil Protection Act (2003:778) and related decrees, regulations and guidelines.

 
 Escape routes may not be blocked.

 

Article 9      Professional membership where applicable

 
 The Tenant shall be under the obligation to be a member of the
professional association active on the given property, and to pay the relevant membership fee, as well as to comply with all decisions taken by this professional association.

 

Article 10    Surrender of the premises

 
 At the end of the lease, the Tenant is responsible for returning
the leased premises in a condition that is clean and in a generally acceptable condition. In the event that the premises are lacking in terms of cleanliness or maintenance, the Landlord shall be entitled to have the premises cleaned and/or repaired
at the Tenant’s cost.
  
 At the latest on the day of
the termination of the lease, the Tenant shall, at his own cost, remove all of his property such as goods, stocks, signs, etc. Property that has not been removed shall be considered abandoned and shall become the property of the Landlord, for which
compensation may not be claimed. The Landlord shall have the right, however, to demand that the Tenant proceed to remove waste, etc., or to have this done at the cost of the Tenant.

 
 No compensation shall be paid for changes, extensions or
renovations performed to the premises by the Tenant, unless agreed upon in writing, or following from Chapter 12 Sections 56-60 of the Jordabalk (“Land Code”).

 

Section 11   Distribution of responsibility in respect of equipment containing
chlorofluorocarbons (CFCs)
  
 The Tenant shall be
responsible for, and where applicable, shall assume the Landlord’s responsibility to ensure that equipment containing CFCs used by the Tenant in their activity complies with all requirements stipulated under the Swedish Environmental Code, and
in ancillary legislation thereto.
  
 Inter alia, this
shall mean that, in pursuance of The Refrigerants Order, the Tenant shall be obligated to ensure compliance with all rules in respect of notification, annual inspection and reporting to authorities.

 
 The Tenant’s obligations shall include maintenance,
requisite exchange or new installation of equipment, etc. and notification.
  
 Article 12    Reduction of rent during normal maintenance
  

The Tenant shall have no right of reduction of the rent due to impediment or detriment of the right of use and enjoyment as a
consequence of the Landlord performing normal maintenance or renovation of the rented premises or other parts of the property. However, it shall be incumbent upon the Landlord to inform the Tenant well in advance about the type and scope of the work
and when and during which time the work will be performed. The Landlord shall minimize disruptions to the Tenant to the greatest possible extent during the execution of said measures.

			
	Signature	  	 Place/date
 [hw:]
Malmö 080317
	  	 Place/date
 [hw:]
080313

			
		  	 Landlord
 I-Parken i Lund
AB
  
 [signature]
                        [signature]
  

[stamp:] Peter Olsson
	  	 Tenant
 Novozymes Biopharma
AB
  
 [signature]

 
 [stamp:] Johan Sjöstedt

	
	

 Page 1(2) 

 

 Page 1(1) 
 Lease Agreement Appendix 
 Appendix no. 4 

 

					
	Concerning	  	 Lease agreement no.
 33001 7739
01
	  	 Premises
 Hunnerup
1

			
	Landlord	  	I-Parken i Lund AB	  	 National ID/company registration no.
 556263-8394

			
	Tenant	  	Novozymes Biopharma AB	  	 National ID/company registration no.
 556627-0830

 [initialed] [initialed] 

 Page 2(2) 

 

			
	 Addendum
	  	 The lease period for the above lease agreement is extended from 01/01/2008 up to and including, 12/31/2008.

 
 Termination of the contract shall be done in writing at least 6 months before the end
of the new lease period, otherwise the contract is extended automatically by 12 months each time. The amount of the rent increases per annum at a rate of 3% as levied on the current rent (137,143 Swedish kronor) starting on
01/01/2008.

 Page 3(2) 

 

					
	 Signature
	  	 Place/date
 [hw:] [illegible]
071001
	  	 Place/date
 [hw:] [illegible]
9/28 2007

			
		  	 Landlord
 I-Parken i Lund
AB
  
 [signature]

 
 [stamp:] Johan Sjöstedt
	  	 Tenant
 Novozymes Biopharma
AB
  
 [signature]

 Page 4(2) 

 

 Page 1(1) 
 Lease Agreement Appendix 
 Appendix no. 

 

					
	Concerning	  	 Lease agreement no.

4301-7724-07
	  	 Premises
 Hunnerup
1

			
	Landlord	  	I-Parken i Lund AB	  	 National ID/company registration no.
 556263-8394

			
	Tenant	  	Novozymes Biopharma AB	  	 National ID/company registration no.
 556627-0830

 Page 5(2) 

 

			
	Addendum	  	 The parties have today agreed to add the following addendum to this lease agreement.

 
 The lease agreement shall also include signs as indicated in the appended design
drawing. All terms and conditions therein shall comply with the above lease agreement.
  
 The price of each sign is 25,000 Swedish kronor (2010 price level as per October 2010 price index) and each sign shall be charged first when it has been set up/installed.

 
 The lease agreement shall remain in effect with no other amendments to the terms and
conditions thereof.

 Page 6(2) 

 

					
	Signature	  	 Place/date
 [hw:] Malmö
12/14/2009
	  	 Place/date
 [hw:] [illegible]
11/23/2009

			
		  	 Landlord
 I-Parken i Lund
AB
  
 [signature]

 
 [hw:] FREDRIK ANGELDORFF
	  	 Tenant
 [stamp:] Novozymes
Biopharma AB
  
 [signature]

 (ENGLISH TRANSLATION) 
 The Swedish Property Owners’ Association Form for free text to be used together with the Property Owners’ Association’s other contract forms. 

Lic. no. 2160-3442-6750-20. Version no. 6.0. Licensed to: Realia Fastighets AB. 

To bldng: 
  

					
		 	BRANDSKYDD = FIRE PROTECTION	 	
		 	HÄNVISNINGAR = INSTRUCTIONS	 	
		 	FÖRESKRIFTER = REGULATIONSAmendment No. 1 to Strategic Supplier Alliance Agreement

 Exhibit 10.19 
 AMENDMENT NO. 1 TO STRATEGIC SUPPLIER ALLIANCE AGREEMENT 
 THIS AMENDMENT
NO. 1 (the “Amendment”) to that certain Strategic Supplier Alliance Agreement dated as of January 28, 2010 (the “Supplier Agreement”), by and between Repligen Corporation, a Delaware corporation
(“Supplier”), and GE Healthcare Bio-Sciences AB, a company organized under the laws of Sweden (“GEHC”), is entered into on October 27, 2011, by and between Supplier and GEHC. 

W I T N E S S E T H: 
 WHEREAS, Supplier expects to enter into an agreement (the “Purchase Agreement”) on or about the date hereof, by and among Supplier, Novozymes Biopharma DK A/S, a company organized under
the laws of Denmark (“Novozymes Denmark”), and the other parties thereto, pursuant to which Novozymes Denmark proposes to sell the manufacturing and supply business of cell culture ingredients and protein A affinity ligands for use
in industrial cell culture, stem and therapeutic cell culture and biopharmaceutical manufacturing run by Novozymes Denmark and Novozymes Biopharma Sweden AB, a company organized under the laws of Sweden and a wholly-owned subsidiary of Novozymes
Denmark (“Novozymes Sweden”), to an affiliate of Supplier (the “Transaction”); 
 WHEREAS,
Section 19.8 of Attachment E (General Terms and Conditions) to the Supplier Agreement provides that the Supplier Agreement may be modified only by a writing signed by both Supplier and GEHC; and 

WHEREAS, Supplier and GEHC desire to amend the Supplier Agreement and Attachments thereto as provided in this Amendment. 

AGREEMENT: 
 NOW, THEREFORE, in consideration of the mutual agreements herein set forth, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto
agree as follows: 
 1. Defined Terms. Capitalized terms used herein, unless otherwise defined herein, shall have the
meanings ascribed to them in the Supplier Agreement. 
 2. Amendment to the Supplier Agreement. 

(a) The second paragraph titled “Agreement Term” of Section C of the Supplier Agreement shall be amended
and restated in its entirety as follows: 
 “Agreement Term: This Agreement shall commence on the Effective Date and,
subject to the rights of termination in clause 16 of Attachment E, shall continue until January 28, 2015 (the “Term”); provided that the Term shall continue until December 31, 2021 if the manufacturing and supply business of cell
culture ingredients and protein A affinity ligands for use in industrial cell culture, stem and therapeutic cell culture and biopharmaceutical manufacturing run by Novozymes Biopharma DK A/S, a company organized under the laws of Denmark
(“Novozymes Denmark”), and Novozymes Biopharma DK A/S, a company organized under the laws of Denmark and a wholly-owned subsidiary of Novozymes Denmark (“Novozymes Sweden”), is transferred to Supplier or an affiliate of Supplier
(the “Transaction”) by December 31, 2011 (the 

  
 Portions of this
Exhibit were omitted and have been filed separately with the Secretary of the Commission pursuant to the Company’s application requesting confidential treatment under Rule 24b-2 of the Exchange Act; [*] denotes omissions. 

 
“Outside Date”). The Parties shall negotiate eighteen (18) months prior to the expiration of the Term (including any extensions thereof as provided herein) to decide whether to
renew this Agreement.” 
 (b) Attachment C of the Supplier Agreement shall be amended by replacing each
of the two (2) occurrences of the phrase “Price ladder 2014” with the phrase “[*]”. 
 (c) Section 9 of Attachment E of the Supplier Agreement shall be amended to include a new Section 9.3 as follows: 
 “The Supplier and GEHC agree to each use commercially reasonable efforts to define Supplier’s internal contingency arrangements to support GEHC’s continuity of supply regarding both
(a) Supplier and its main operating facility as of the date hereof in Waltham, Massachusetts, United States and (b) if the Transaction is consummated, Novozymes Sweden and its main operating facility as of the date hereof in Lund, Sweden
in order to meet GEHC’s customers’ requirements for documenting security of supply to the extent reasonably practicable. The Supplier agrees to provide GEHC with a revised draft of such contingency arrangements for review. GEHC agrees to
notify the Supplier in writing of any proposed revisions to such draft contingency arrangements within [*] ([*]) days of receipt, which proposed revisions shall thereafter be considered by Supplier, and mutually discussed by Supplier
and GEHC, each acting reasonably, until promptly resolved; provided that if GEHC fails to deliver any such written notice of any proposed revisions to Supplier within [*] ([*]) days of receipt, then GEHC will be deemed to
have accepted such contingency arrangements submitted by Supplier.” 
 3. Effect of Amendment. In the event that the
Transaction is not consummated by December 31, 2011, GEHC and Supplier shall each have the right to terminate unilaterally this Amendment by giving the other party hereto written notice no later than fifteen (15) days following such date
and, if such notice is delivered, this Amendment and the changes to the Agreement contemplated hereby shall be of no force or effect. The parties hereto agree that except as otherwise set forth herein, all terms of the Supplier Agreement shall
remain in full force and effect. In the event of any inconsistency or conflict between the Supplier Agreement and this Amendment, the terms, conditions and provisions of this Amendment shall govern and control. 

6. Entire Agreement. This Amendment and the Supplier Agreement, including the Attachments, exhibits, schedules and other documents
referred to therein which form a part thereof, contain the entire understanding of the parties hereto with respect to the subject matter contained herein and therein. From and after the execution of a counterpart hereof by the parties hereto, any
reference to the Supplier Agreement shall be deemed to be a reference to the Supplier Agreement as amended hereby. 
 7.
Governing Law. This Amendment and any disputes hereunder shall be governed by and construed in accordance with the laws of State of New York without giving effect to the conflict of law principles thereof. The United Nations Convention on
Contracts for International Sales of Goods shall not apply to this Amendment. 
 8. Counterparts. This Amendment may be
executed in any number of counterparts and any party hereto may execute any such counterpart, each of which when executed and delivered shall be deemed to be an original and all of which counterparts taken together shall constitute but one and the
same instrument. Any signature page delivered by a facsimile machine shall be binding to the same extent as an original signature page with regard to any agreement subject to the terms hereof or any amendment thereto. 

  
 Portions of this
Exhibit were omitted and have been filed separately with the Secretary of the Commission pursuant to the Company’s application requesting confidential treatment under Rule 24b-2 of the Exchange Act; [*] denotes omissions. 

 [SIGNATURE PAGES FOLLOW] 

  
 Portions of this
Exhibit were omitted and have been filed separately with the Secretary of the Commission pursuant to the Company’s application requesting confidential treatment under Rule 24b-2 of the Exchange Act; [*] denotes omissions. 

 IN WITNESS WHEREOF, the undersigned have caused this Amendment to be executed and delivered
as of the date first above written. 
  

			
	SUPPLIER:
	
	Repligen Corporation
		
	By:	 	 /s/ Walter Herlihy

			
	Name: Walter Herlihy
	Title: Authorized Signatory
	
	GEHC:

 
			
	
	General Electric Company on Behalf of its Division, GE Healthcare
		
	By:	 	 /s/ Magnus Lundgren

			
	Name: Magnus Lundgren
	Title: Global Sourcing Executive

  
 Portions of this
Exhibit were omitted and have been filed separately with the Secretary of the Commission pursuant to the Company’s application requesting confidential treatment under Rule 24b-2 of the Exchange Act; [*] denotes omissions.

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