Document:

exv4w11

 

1288

Exhibit 4.11

Joint Venture Agreement

Agreement on the establishment of a Silent Partnership

	 	 	 
	between

	 	and
	 
	 	 
	     Micromet GmbH

	 	      tgb Technologie Beteiligungs-
	 
	 	 
	     Am Klopferspitz 19

	 	     Gesellschaft mbH der
	 
	 	 
	 

	 	     Deutschen Ausgleichsbank
	 
	 	 
	     82152 Martinsried

	 	     53179 Bonn
	 
	 	 
	hereinafter: Technology Corporation (TC) -

	 	- Silent Partner; hereinafter: tgb

in the amount of

*** DM 513,274.00 ***

(I n words: five hundred thirteen thousand two hundred seventy-four Deutschmarks)

for the financing of the project described in §1 para. 2

Preamble

	 	 	Within the framework of the DtA technology investment program, tgb shall assume investments for
financing of projects in the start-up phase, of innovation-related projects, and of exit financing
projects as defined by the investment principles of this program, which are an integral part of
this Agreement.

§1

Corporate Purpose

	1.	 	The TC registered with the Municipal Court (Amtsgericht) Munich under number B105424 engages
in a trade pursuant to the Articles of Incorporation dated December 16,1993 with the purpose
of:

	 	 	Implementation of biomedical contract research within the scope of development of products for
diagnosis and treatment of human diseases

	2.	 	Within the scope of this corporate purpose,

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	 	 	the TC engages in bringing previous product developments for treatment of minimally residual
carcinoma into the clinical phase, supplemented by the development of a product for cancer of the
lymphatic system.

§ 2

Contribution

	1.	 	tbg shall assume a contribution in the amount of DM 513,274.00, exclusively for financing of
the innovation-related project described in § 1 para. 2 and based on the information furnished
by the TC in the investment solicitation dated August 6, 1998, if the TC provides evidence of
the following joint venture agreements:

	 	ð 	 	Joint venture agreement in the amount of DM 930,159.00 with
	 
	 	 	 	     Atlas Venture Germany B.V.
	 
	 	 	 	     PO Box 5225
	 
	 	 	 	     NL- 1410 Naarden
	 
	 	 	 	     The Netherlands
	 
	 	 	 	     (hereinafter: Investor, even in case of more than one investor)
	 
	 	 	 	and the Investor with whom tbg has executed a Cooperation Agreement.
	 
	 	ð	 	Direct debit authority for collection of all due fixed compensation through tbg
	 
	 	ð	 	Investment by additional investors in the amount of at least DM 6,478,536.00

	2.	 	tbg’s contribution shall be appropriated for co-financing of the project-specific planning
listed in Appendix I, which an integral part of this Joint Venture Agreement.

	3.	 	The TC can call up the contribution after start-up of the corporation (cf. § 3 para. 1)
provided that its prompt utilization in accordance with its specified purpose, a proportionate
use of funds with the other financing funds listed in Appendix I, and the total financing of
the innovation-related project are guaranteed.

	 	 	A confirmation of the requirements for the call shall be attached to the call by the Investor.

	4.	 	This Agreement shall be terminated if the contribution has not been called, at least in part,
no later than May 31,1999.
	 
	5.	 	tbg shall withhold a processing fee in the amount of 1.00% of the total contribution agreed
on in this Agreement for the first partial call.
	 
	6.	 	tbg’s contribution shall be kept in a special deposit account to be handled by the TC.
Withdrawals by tbg from this account are not permitted.

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§3

Commencement and Duration of the Corporation

	1.	 	The Silent Partnership shall commence as soon as this Agreement has been executed by both
parties.

	2.	 	The Silent Partnership is limited in time until December 31, 2008.

	3.	 	Upon termination of the partnership, tbg’s contribution and any profit shares not paid out
shall be due to tbg.

	4.	 	Insofar as the funds granted by the Investor have been paid back prior to December 31, 2008,
tgb’s contribution shall be due for repayment at the same time and to the same extent. tbg is
entitled to request final compensation pursuant to § 8 para. 4 mutatis mutandis for that
portion of its contribution, which is due for early repayment.

§4

Management

	1.	 	tbg shall not participate in the management of the TC, except as otherwise provided herein.

	2.	 	The TC is required to obtain tbg’s consent for

	 	a)	 	Each change of the Articles of Incorporation, including but not limited to any change
in the corporate purpose, acceptance of new partners, or agreement on new investments;
	 
	 	b)	 	Appointment or dismissal of managers of the TC or changes to the Management Employment
Agreement;
	 
	 	c)	 	Execution, amendments, and termination of contracts with respect to the granting or
acquisition of licenses, trademarks, or know-how (except with respect to the day-to-day
software business), patents, utility and design patents, insofar as they concern the
innovation-related project developed using tbg’s investment;
	 
	 	d)	 	Execution, amendments, and termination of major distribution contracts;
	 
	 	e)	 	Partial or complete site relocation, or leasing, disposal, or shut-down thereof;
	 
	 	f)	 	Execution and termination of controlling agreements and profit-and-loss transfer agreements;
	 
	 	g)	 	Abandonment of or essential changes in the innovation-related project described in § 1 para.
2;
	 
	 	h)	 	Acceptance by tbg of obligations, insofar as these are not part of project financing,
for investments that are in excess of DM 100,000 or for leasing or rental agreements or
leases in excess of a monthly amount of DM 10,000.

	3.	 	Consents pursuant to § 4 para. 2 shall be obtained directly from tbg.
	 
	 	 	Insofar as tbg does not state in writing the refusal to grant consent pursuant to § 4 para. 2
within a period of 14 days after receipt of notice of measures requiring approval, consent shall
be deemed granted.

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§5

Information and Control Rights

	1.	 	The TC shall inform tbg every six months, no later than March 31 and September 30
respectively of each year regarding the economic situation of the TC and with respect to the
innovation-related project described in § 1 para. 2, as long as tbg does not waive these
reports because the Investor is also concurrently performing the control review of the TC for
tbg. tbg shall also receive from the TC a brief, monthly state of affairs summary report in
accordance with the attached Appendix II and, at the end of the fiscal year, a properly
updated business plan for the following year.
	 
	2.	 	Regardless of whether the Investor is performing the control review of the TC concurrently
for tbg, the TC shall inform tbg directly and in a timely manner with respect to all measures
extending beyond standard business procedures.
	 
	3.	 	Additionally, tbg is entitled to control rights pursuant to § 716 of the German Civil Code
(BGB). This also applies after termination of the corporation to the extent necessary to
review the liquidation balance.
	 
	 	 	tbg is also entitled to access all of the TC’s documents with reference to the innovation-related
project described in § 1 para. 2. tbg can use third-party services when exercising its control
rights.
	 
	4.	 	The Federal Audit Office (Bundesrechnungshof) is entitled to audit the TC pursuant to § 91 of
the Federal Budget Code (BHO). The TC shall furnish all documents that the Federal Audit
Office deems necessary to the Federal Audit Office and tbg for audit purposes and shall
furnish all appropriate information.

§ 6

Advisory Board

	 	 	tbg can request constitution of an Advisory Board at any time. tbg shall participate in this
Advisory Board commensurately with the amount of its contribution. The Advisory Board shall advise
the TC with respect to economic and technical aspects, including but not limited to with respect to
the project described in § 1 para. 2. The Advisory Board shall have the same information and
control rights that tbg is entitled to under this Agreement.

§ 7

Business Year; Annual Financial Statement

	1.	 	The fiscal year of the Silent Partnership shall correspond to that of the TC (“investment
year”). The TC’s fiscal year shall end on December 31 of each year.

	2.	 	The TC shall draw up its annual financial statement (balance sheet, statement of income,
notes) in compliance with §§ 238 – 289 of the German Commercial Code (HGB) within six months
after the end of the fiscal year and shall furnish an original, signed copy of this financial
statement to tbg with the attestation of an auditor or certified accountant.

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§8

Profit and Loss Sharing

	1.	 	For its contribution, tbg shall receive a minimum compensation independent of the TC’s net
income in the amount of 7.00% per annum. Such compensation shall be due in arrears every six
months as of May 31 and November 30 of each year.
	 
	2.	 	Additionally, tbg shall receive 9.00% of the annual net income generated after call up of the
contribution.
	 
	 	 	For a period in which tbg holds more than one investment in the TC, tbg shall receive only 9.00%
for all investments, aside from the respective minimum compensations from the generated annual net
income.
	 
	 	 	If additional capital is put into the TC within the scope of additional financing rounds, tbg shall
adjust its profit share to the capital conditions valid at that time.
	 
	 	 	This profit share is payable within 2 weeks upon approval of the annual financial statement (§ 7
para. 2).
	 
	3.	 	The annual net income before recognition of tbg’s profit share is applicable for the
calculation as defined by para. 2.

	 	a)	 	To be added to the annual net income:

	 	-	 	Taxes on income and managers’ royalties, if any, to the extent that
they have reduced the posted annual net income;
	 
	 	-	 	Extraordinary expenditures, insofar as they originate from business
events prior to commencement of the Silent Partnership;
	 
	 	-	 	Losses from disposal or destruction of fixed assets, insofar as these
were existent at the time of commencement of the corporation.
	 
	 	b)	 	To be deducted from the annual net income:
	 
	 	-	 	Amounts from the liquidation of tax-free reserves that were established prior to commencement of the Silent Partnership;
	 
	 	-	 	Extraordinary earnings insofar as they are based on business events that took place prior to commencement of the Silent
Partnership;
	 
	 	-	 	Public subsidies, allowances, and appropriations, insofar as they affect net income;
	 
	 	-	 	Earnings from disposals of fixed assets, insofar as these already existed at the time of commencement of the corporation.
	 
	 	c)	 	In the year of the call up of the investment, the annual net income for the calculation of
the profit share as defined by para. 2 shall be deemed as having accrued evenly during the
course of the year.

	4.	 	At the end of the investment period, tbg is entitled to a one-time compensation of 35% of the
investment amount plus 7% of the investment amount for each year after the end of the fifth
full investment year (final compensation). The annually paid profit sharing as defined by § 8
para. 2 shall be set off against the final compensation to be paid. If the sum total of the
profit share exceeds the final compensation, no monies shall be reimbursed.

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	5.	 	If shares of the TC (if applicable, after conversion of the TC into a stock corporation)
are to be admitted to trading on a stock exchange and the TC has executed a letter of
engagement or a comparable document with an underwriting member bank,
tbg can request that shares in the TC be issued or existing shares be transferred to tbg against transfer or
assignment of the entitlement to payment of the final compensation pursuant to para. 4. tbg
shall direct the request to the TC in writing. The amount of the claim is calculated based on
the period from execution of the Joint Venture Agreement until receipt of the request by the
TC in accordance with sentence 1. The number of shares to be issued or transferred to tbg is
calculated by dividing the amount of final compensation by the exercised amount. The exercised
amount is determined from the average of the expected or final established minimum or maximum
amount of the price spread at the time of the initial public offering for one share of the TC;
however, the exercised amount shall not exceed 90% of the highest amount of the price spread.
Insofar as payments based on profit-dependent compensation to tbg are set off against
entitlement to the final compensation, the previous stipulations are applicable mutatis
mutandis to the entitlement to final compensation reduced by this amount.
	 
	 	 	The TC shall inform tbg promptly in writing if an initial public offering is planned and if a
letter of engagement or a similar document has been executed. tbg shall exercise its right to
convert the entitlement to final compensation into shares in the TC within four weeks after receipt
of the TC’s notification. The parties shall effect all acts and make all statements necessary to
cause the issuance or transfer of shares to tbg. The TC shall assert its influence over its
shareholders so that they shall take the necessary actions and make the necessary
declarations—including but not limited to with respect to a possible capital increase. If, prior to
the completion of the investment in the TC by tbg on the basis of the exercise of the option, the
listing of the TC’s shares for trading on a stock exchange is no longer being pursued, tbg can
demand that the option be deemed not exercised, to the extent that actions completed and
declarations given up to the time of the appropriate statement can still be rescinded; in this
case, tbg’s option privilege shall continue to exist and can be exercised again if the previously
stated requirements have been met.
	 
	6.	 	tbg shall not participate in the TC’s losses.

§9

Taxes

	 	 	The TC shall take care of payment of the legally required capital gains tax plus solidarity
surcharge with respect to the compensation for the silent contribution, shall withhold capital
gains tax and the solidarity surcharge from the payments to tbg, and shall pay them to the
appropriate Tax Office as soon as they become due. Upon payment thereof, the TC shall within 2
months after the payments to the Tax Office became due furnish, on the forms provided by tbg,
attestations as defined by § 45a para.2 of the Income Tax Act (EStG).

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§10

Liquidation of the Silent Partnership

	1.	 	In case of liquidation of the TC, the Silent Partnership shall be liquidated. In this case,
the silent contribution shall be repaid.
	 
	2.	 	In this case, § 8 para. 4 shall apply.

§11

Termination

	1.	 	The TC is entitled to redeem tbg’s investment in whole or in part with a period of notice of
3 months on June 30 or December 31 of each year. If such redemption is made before the end of
the fifth full investment year, tbg’s contribution shall be repaid with a premium of 35%. The
provision under § 8 para. 4 applies as of the start of the sixth investment year. tbg can
waive payment of the premium if the termination was made due to abandonment of the
innovation-related project developed as defined in § 1 para. 2.

	2.	 	Additionally, the Silent Partnership can be terminated in writing by either partner for due
cause without a period of notification. Insofar as the contribution has not yet been made in
whole or in part, tbg shall be free of its contribution obligation at the time the Silent
Partnership is terminated.
	 
	 	 	tbg is entitled to terminate the Agreement for due cause for reasons that include but are not
limited to the following:

	 	a)	 	If the TC furnished incorrect information in the investment solicitation;
	 
	 	b)	 	If it becomes apparent that the requirements for the granting or continuation of the joint
venture were not met or that the requirements for the continuation of the joint venture no
longer exist, including but not limited to if the innovation-related project cannot be
implemented as defined in § 1 para. 2, or is abandoned by the TC, or is significantly amended.
If the innovation-related project as described in § 1 para. 2 proves to be technically
unfeasible or cannot be implemented for economic reasons, tbg can waive repayment of the
investment in whole or in part, if such an action enables the TC’s continued existence;
	 
	 	c)	 	If bills of exchange accepted by the TC are protested, the TC stops payments, a bankruptcy
petition has been filed, or insolvency has been determined in any other way;
	 
	 	d)	 	If the managers with the appropriate expertise employed by the TC at the time of execution of
the Joint Venture Agreement relative to the Silent Partnership no longer work at the corporate
management level of the TC;
	 
	 	e)	 	If one of the actions stipulated in § 4 para. 2 was implemented without prior consent of tbg.

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§12

Due Payments

	 	 	In the event of payment default, due payments shall accrue interest in the amount of 4% per annum
until they have been received by tbg.

§13

Miscellaneous provisions

	1.	 	Amendments and additions to this Agreement shall be in writing. No oral ancillary agreements
to this Agreement have been made.
	 
	2.	 	If a provision in this Agreement should be or become invalid, the remaining provisions shall
remain unaffected. The TC and tbg are obligated to replace invalid provisions with such
provisions that are valid and that correspond to the greatest extent possible to the spirit
and economic purpose of the invalid provision.
	 
	3.	 	Bonn is agreed upon as venue for any and all disputes arising from this Agreement and its
implementation.

	 	 	 
	Bonn,
dated: March 2, 1999 

Technologie-Beteiligungs-

	 	Martinsried, dated:
February 15, 1999 

Micromet GmbH
	
Gesellschaft mbH der
	 	 
	 

	 	

	Deutschen Ausgleichsbank

	 	[signature]
	 
	 	 
	[signature]      [signature]
	 	 

Project specific planing (Appendix I)

Brief statement of affairs summary (Appendix II)

Investment principles of tbg (Appendix III)

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Project-Specific Planning

Appendix I

Projected time period: September 30, 1998 until December 31, 2000

	 	 	 	 	 	 
	Project-Specific
Expenditures	 	 	Amount without value-added tax
	 
	I. Applied research and development
	 	 	 	 	 
	I. Investments shown in the intangible fixed assets
	 	 	 	 	 
	1.1 Lab devices and equipment
	 	 	 	DM	104,759.00
	1.2 Machinery and equipment for production of prototype
	 	 	 	DM	0.00
	1.3 Other
	 	 	 	DM	0.00
	2. Non-investive research and development expenses
	 	 	 	 	 
	2.1 Personnel
	 	 	 	DM	1,031,344.00
	2.2 Material
	 	 	 	DM	362,398.00
	2.3 Third-party services (contract award/ consulting)
	 	 	 	DM	59,953.00
	2.4 Patents and permits
	 	 	 	DM	81,252.00
	2.5 Travel expenses
	 	 	 	DM	86,931.00
	2.6 Other
	 	 	 	DM	415,567.00
	II. Investments for market launch
	 	 	 	DM	0.00
	 
	Total
	 	 	 	DM	2,142,204.00
	 

	 	 	 	 	 	 	 
	Project-Specific Financing	 	 	 	Amount
	 
	1. Equity capital
	 	 	 	DM	318,065.00	 
	1.1 —
	 	 	 	 	 	 
	1.2 —
	 	 	 	 	 	 
	2. Investment capital
	 	 	 	 	 	 
	2.1 of tbg
	 	 	 	DM	513,274.00	 
	2.2 of lead investors
	 	 	 	DM	930,159.00	 
	2.3 other participating parties
	 	 	 	DM	238,713.00	 
	3. Public funding
	 	 	 	 	 	 
	3.1 subsidies, allowances, appropriations
	 	 	 	DM	0.00	 
	3.2 Other
	 	 	 	DM	141,933.00	 
	4. Outside capital
	 	 	 	 	 	 
	4.1 from bank
	 	 	 	DM	0.00	 
	4.2 Other
	 	 	 	DM	0.00	 
	 
	Total
	 	 	 	DM	2,142,204.00	 
	 

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Fax-No.: 0228/ 831 24 93 Esko Stahl

Appendix II

Brief Statement of Affairs Summary

Micromet GmbH

Am Klopferspitz 19

82152 Martinsried

Brief statement of affairs summary for the month of *           199

	 	 	 	 	 
	 	 	Balance in	 
	 	 	thousands of DM	 
	 
	Sales revenue
	 	 	 	 
	Material expenses
	 	 	 	 
	Personnel expenses
	 	 	 	 
	Other expenses
	 	 	 	 
	Provisional operating result
	 	 	 	 
	Current volume of orders
	 	 	 	 
	Credit framework
	 	 	 	 
	Of which utilized
	 	 	 	 
	 
	Current number of employees (please
state temporary employees in percent)
	 	 	 	 

Noteworthy events during the past month:

Assessment of Future Development

o much better           o better           o same           o worse   
o much worse     

Martinsried, dated:

 

Corporate Stamp and Signature(s)

 

     Always due no later than at the end of the following month
 

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Exhibit 4.12

Amendment Agreement

to the Participation Agreements

     by and among

     1. tbg Technologie-Beteiligungs-Gesellschaft mbH, Ludwig-Erhard-Platz 3, 53179 Bonn

     - hereinafter also referred to as “tbg” -

     2. Micromet AG, Staffelseestr. 2, 81477 Miinchen/Munich, eingetragen im Handelsregister des
Registergericht Miinchen unter/registered with the Commercial Register of the Munich Local Court
under HR B 133 040,

     - hereinafter also referred to as “Micromet” or “TU” -

Preamble

     A. tbg and Micromet have entered into a total of six participation agreements establishing
silent partnerships among tbg and Micromet. In detail the following contracts are concerned:

	 	 	 	 	 	 	 
	tbg No.	 	Nominal Value	 	Final Compensation***)	 	Contract Start
	0268 321 / I
	 	716.064,28  €	 	6 %**)	 	14./25.10.96
	0268 322 / II
	 	177.009,25  €	 	6 %**)	 	14./25.10.96
	0268 323 / III
	 	164.453,45  €	 	6 %**)	 	15.02./02.03.99
	0268 324 / IV
	 	476.348,66  €	 	6 %**)	 	15.02./02.03.99
	0268 341 * / V
	 	262.432,83  €	 	7 %***)	 	15.02./02.03.99
	0268 342 * / VI
	 	760.150,93  €	 	7 %***)	 	15.02./02.03.99
	 	 	 	 	 	 	 
	Total
	 	2.556.459,40  €	 	0	 	0
	 	 	 	 	 	 	 

	 		
	*	 	additional option right of tbg for conversion into shares.
	 
	**	 	for the first 5 years 30 % flat, thereafter for each commenced contract year in % of the
nominal value.
	 
	***	 	for the first 5 years 35 % flat, thereafter for each commenced contract year in % of the
nominal value.

     B. The participation agreements were entered into among tbg, at that time acting under
the name of tbg Technologie-Beteiligungs-Gesellschaft mbH der Deutschen Ausgleichsbank, and
Micro-met AG. The silent partnership agreements were registered with the Commercial Register on 7
September 2000 pursuant to § 292 (2) No. 1 German Stock Corporation Act.

     C. The shareholders of Micromet AG intend to contribute their shares in the Company to
Micromet, Inc., with its registered seat in Delaware, USA. This company shall

 1.

 

henceforth act under
the name Micromet, Inc., Delaware, USA. To this end, on 6 January 2006, Micro-met AG entered into
an Agreement and Plan of Merger and Reorganization with Micromet, Inc., Deleware, CancerVax
Corporation, Delaware and Carlsbad Acquisition Corporation, Delaware with the consent of tbg
(hereinafter also referred to as “Merger Agreement”). The parties intend to amend the participation
agreements in light of the forthcoming change of the shareholder structure.

     NOW, THEREFORE, the parties hereby agree as follows:

§1

Repayment of the Participation Agreements I — IV

     1. The parties are in agreement that the nominal values of the Participation Agreements I — IV
shall become due for repayment to tbg within 14 days after the consummation of the merger of
Carlsbad Acquisition Corporation with and into Micromet, Inc. as provided for in the Merger
Agreement. Up to that date, the minimum compensation in the amount of 6.0 % p.a. gross shall be
paid in accordance with the agreements. Within 14 days after the consummation of the merger, TU
shall pay to tbg an amount of in total EUR 2,000,000.00 gross in satisfaction of tbg’s claim for
repayment of the nominal values of the Participation Agreements I — IV and in satisfaction of all
claims of tbg for final compensation under the Participation Agreements I — IV as well as all other
claims of tbg under the Participation Agreements I — IV. The parties are in agreement that after
the payment of the minimum compensation under sentence 2 above and the payment of in total EUR
2,000,000.00 gross under sentence 3 above, the Participation Agreements I -IV shall be finally
settled and no further claims of whatever kind among the parties out of or in connection with the
Participation Agreements I — IV, irrespective of their legal grounds, whether known or unknown,
exist anymore.

     2. The parties are further in agreement that the consummation of the transactions contemplated
in the Merger Agreement does not have any impact on the term of the Participation Agreements V and
VI and that these accordingly have a fixed term up until 31 December 2008 at which point in time
they become due for repayment to tbg together with the final compensation agreed in the contracts.

§2

Profit and Loss Participation

     1. Sentence 3 of § 9 (4) of the Participation Agreements I — IV is deleted. The parties are
in agreement that tbg does not participate in losses of neither TU nor Micromet, Inc.

     2. This amendment shall apply for the first time to the current business year 2006.

     3. Save as provided otherwise, the provisions of the Participation Agreements I -VI remain
unaffected.

 2.

 

§3

Further Amendments

     § 12 (2) d) of the Participation Agreements I — IV as well as § 11 (2) c) of the Participation
Agreements V- VI shall apply accordingly with regard to Micromet, Inc., Delaware, USA.

§4

Condition Precedent

     This amendment agreement shall come into force as soon as all of the following conditions are
fulfilled:

     a) Consent of the Shareholders’ Meeting of Micromet AG to the present amendment agreement;

     b) Production of a guarantee declaration duly signed by Micromet, Inc. in accordance with the
form attached as Annex A;

     c) Contribution of more than 80 % of the shares in Micromet AG to Micromet, Inc.

§5

Consent

     tbg hereby grants its consent pursuant to § 5 of the Participation Agreements I — IV and § 4
of the Participation Agreements V — VI to the contribution of the shares in Micromet AG in
Micromet, Inc. as provided in detail in the Merger Agreement. After the consent of the
Shareholders’ Meeting has been granted, Micromet AG will cause the registration of this Amendment
Agreement with the Commercial Register without undue delay.

§6

Final Provisions

     1. Changes and amendments to this Agreement require the written form. Oral side agreements to
this Agreement do not exist.

     2. In the event that a provision of this Agreement is invalid, the validity of the remaining
provisions shall not be affected thereby. TU and tbg are under an obligation to replace invalid
provisions of this Agreement by such valid provisions, which correspond to the intent and purpose
of the invalid provisions to the closest possible extent.

 3.

 

     3. Place of jurisdiction for all disputes out of this Agreement or its performance shall be
Bonn.

	 	 	 	 	 
	Bonn, 6 February 2006

	 	Munich, the 30 January 2006
	 	 
	 

	 	 	 	 
	/s/ Michael Steinmetzer

	 	/s/ Gregor K. Mirow	 	 
	 	 	 	 	 
	(tbg)

	 	(Micromet)	 	 

 4.

 

Exhibit
4.12

Annex A

[Letterhead of Micromet, Inc., Delaware, USA]

tbg Technologie-Beteiligungs-Gesellschaft mbH

Ludwig-Erhard-Platz 3

53179 Bonn

Dear Sir or Madam,

     Micromet, Inc., Delaware, USA hereby assumes the unconditional and irrevocable guarantee

     a) for the payment of the respective annual minimum compensation pursuant to § 9 (1) or §8 (1)
as well as

     b) for the repayment of the respective participation capital in case of a termination of the
participation due to the end of the fixed term, a declaration of termination or for other reasons
as well as

     c) for damage claims of tbg, irrespective of their legal ground as well as

     d) for the payment of the profit participation pursuant to § 9 (2) and (3) or § 8 (2) and (3)
as well as

     e) for the payment of the final compensation pursuant to § 9 (4) or § 8 (4)

out of the existing six participation agreements among you and Micromet AG, Munich with nominal
values in the amount of in total
 € 2,556,459.40:

	 	 	 	 	 	 	 
	tbg No.	 	Nominal Value	 	Final Compensation***)	 	Contract Start
	0268 321 / I
	 	716.064,28  €	 	6 %**)	 	14./25.10.96
	0268 322 / II
	 	177.009,25  €	 	6 %**)	 	14./25.10.96
	0268 323 / III
	 	164.453,45  €	 	6 %**)	 	15.02./02.03.99
	0268 324 / IV
	 	476.348,66  €	 	6 %**)	 	15.02./02.03.99
	0268 341 * / V
	 	262.432,83  €	 	7 %***)	 	15.02./02.03.99
	0268 342 * / VI
	 	760.150,93  €	 	7 %***)	 	15.02./02.03.99
	 	 	 	 	 	 	 
	Total
	 	2.556.459,40  €	 	 	 	 
	 	 	 	 	 	 	 

     The Participation Agreements I — VI were amended by an amendment agreement to the
participation agreements dated                            2006 among tbg and Micromet AG.

 1.

 

     Micromet, Inc., Delaware, USA is only entitled to raise such objections or defenses which
could be raised by Micromet AG, Munich as well. Insofar we will honor the claims under a) through
c) upon your first written demand.

     Moreover, the Guarantor unconditionally and irrevocably undertakes for the duration of the
participation agreement (i) to transfer essential parts of Micromet AG, Munich to another company
only with the prior written consent of tbg, except for out-licensing, partnering and similar
transactions of Micromet AG; in this respect, the consent of tbg is only required if this is
provided for in § 5 of the Participation Agreements I – IV and § 4 of the Participation Agreements
V and VI; and (ii) not to dispose of, reduce or in any other direct or indirect way amend the
participations in Micromet AG, Munich in full or in part. Our liability is limited to such claims
which become due at a point in time at which we directly or indirectly hold a majority interest in
Micromet AG.

     Micromet, Inc. undertakes to forward to tbg an originally signed copy accompanied by an audit
certificate of a person entitled to such audit of the consolidated annual financial statements
drawn up and audited in accordance with the provisions of the jurisdiction applicable to it without
undue delay after the audit is completed.

     Micromet, Inc. undertakes to ensure that the Shareholders’ Meeting of Micromet AG consents to
the amendment agreement to the participation agreements with tbg immediately after the acquisition
of the shares in Micromet AG, Munich by Micromet, Inc., unless such consent has already been given.

     This guarantee is subject to the laws of the Federal Republic of Germany. Exclusive place of
jurisdiction shall be Bonn.

     Sincerely yours,

     The above guarantee is hereby acknowledged:

     Bonn, the _______________

     ________________________

 2.

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