Document:

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                                                                    EXHIBIT 10.2

                              THE MEDICINES COMPANY

                        2000 EMPLOYEE STOCK PURCHASE PLAN

     The following constitute the provisions of the 2000 Employee Stock Purchase
Plan of The Medicines Company.

     1. PURPOSE. The purpose of the Plan is to provide employees of the Company
and its Designated Subsidiaries with an opportunity to purchase Common Stock of
the Company through accumulated payroll deductions. It is the intention of the
Company to have the Plan qualify as an "Employee Stock Purchase Plan" under
Section 423 of the Internal Revenue Code of 1986, as amended. The provisions of
the Plan, accordingly, shall be construed so as to extend and limit
participation in a manner consistent with the requirements of that section of
the Code.

     2.   DEFINITIONS.

          a.   "BOARD" shall mean the Board of Directors of the Company.

          b.   "CODE" shall mean the Internal Revenue Code of 1986, as amended.

          c.   "COMMON STOCK" shall mean the Common Stock of the Company.

          d.   "COMPANY" shall mean The Medicines Company and any Designated
Subsidiary of the Company.

          e.   "COMPENSATION" means the amount of money reportable on an
Employee's Federal Income Tax Withholding Statement (Form W-2) before any
withholdings for health insurance or under a Section 401(k), 125, 129 or similar
plan, including without limitation, salary, wages, overtime, shift
differentials, bonuses and incentive compensation, but excluding third party
sick or disability pay, allowances and reimbursements for expenses such as
relocation allowances or travel expenses, whether specifically designated as
such or designated as signing bonuses, income or gains attributable to
restricted stock, stock options, stock appreciation rights or other similar
equity based compensation, imputed income for non cash items, such as life
insurance premiums, and similar items, whether or not specifically itemized on
the Form W-2.

          f.   "DESIGNATED SUBSIDIARY" shall mean any Subsidiary which has been
designated by the Board from time to time in its sole discretion as eligible to
participate in the Plan.

          g.   "EMPLOYEE" shall mean any individual who is an employee of the
Company for tax purposes whose customary employment with the Company is more
than five (5) months in any calendar year. For purposes of the Plan, the
employment relationship shall be treated as continuing intact while the
individual is on sick leave or other bona fide leave of absence approved by the
Company. If a sick leave or other leave of absence exceeds 90 days and the
individual's right to reemployment is not guaranteed either by statute or by
contract, the individual's employment relationship with the Company shall be
deemed to have terminated on the 91st day of such leave.

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          h.   "ENROLLMENT DATE" shall mean the first day of each Offering
Period.

          i.   "EXERCISE DATE" shall mean the last Trading Day of each Offering
Period.

          j.   "FAIR MARKET VALUE" shall mean the value of the Common Stock on
any given date of determination, determined as follows:

               (1) If the Common Stock is listed on any established stock
exchange or a national market system, including without limitation The Nasdaq
National Market or The Nasdaq Small Cap Market of The Nasdaq Stock Market, its
Fair Market Value shall be the closing sales price for such stock (or the
closing bid, if no sales were reported) as quoted on such exchange or system on
the date of such determination, as reported in The Wall Street Journal or such
other source as the Board deems reliable; or

               (2) If the Common Stock is regularly quoted on the over-the-
counter market, its Fair Market Value shall be the mean of the closing bid and
asked price for such stock as quoted on such market on the date of such
determination, as reported in The Wall Street Journal or such other source as
the Board deems reliable; or

               (3) In the absence of an established market for the Common Stock,
the Fair Market Value of the Common Stock shall be determined in good faith by
the Board.

          k.   "OFFERING PERIODS" shall mean the periods of approximately six
(6) months during which payroll deductions will be made and held for the
purchase of Common Stock at the end of the Offering Period, commencing on the
first Trading Day on or after September 1 and March 1 of each year and
terminating on the last Trading Day in the periods ending six (6) months later;
provided, however, that the first Offering Period under the Plan shall commence
with the first Trading Day of the month first commencing after the date on which
the Common Stock is first traded on the Nasdaq National Market (such date
referred to as the "First Offering Commencement Date"); and provided further
that if the number of days between the date the Common Stock is first traded and
the First Offering Commencement Date is less than 15 days, then the first
Offering Period shall commence on the first Trading Day of the following month.
The duration and timing of Offering Periods may be changed pursuant to Section 4
of this Plan.

          l.   "PLAN" shall mean this Employee Stock Purchase Plan.

          m.   "PURCHASE PRICE" shall mean eighty-five percent (85%) of the Fair
Market Value of a share of Common Stock on the Enrollment Date on an Offering
Period or on the Exercise Date for such Offering Period, whichever is lower.

          n.   "RESERVES" shall mean the number of shares of Common Stock
covered by each outstanding option under the Plan which has not yet been
exercised and the number of shares of Common Stock which have been authorized
for issuance under the Plan but not yet placed under option.

          o.   "SUBSIDIARY" shall mean a corporation, partnership, limited
liability company or similar entity, whether domestic or foreign, of which not
less than 50% of the voting

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interests are held by the Company or a Subsidiary, whether or not such entity
now exists or is hereafter organized or acquired by the Company or a Subsidiary.

          p.  "TRADING DAY" shall mean a day on which the established stock
exchange, the national market system or the over-the-counter market on which the
Common Stock is traded is open for trading.

     3.  ELIGIBILITY.

         a. Any Employee who shall be employed by the Company at least seven
(7) calendar days prior to a given Enrollment Date shall be eligible to
participate in the Offering Period commencing on such Enrollment Date.

         b. Any provisions of the Plan to the contrary notwithstanding, no
Employee shall be granted an option under the Plan (i) to the extent that,
immediately after the grant, such Employee (or any other person whose stock
would be attributed to such Employee pursuant to Section 424(d) of the Code)
would own capital stock of the Company and/or hold outstanding options to
purchase such stock possessing five percent (5%) or more of the total combined
voting power or value of all classes of the capital stock of the Company or of
any Subsidiary, or (ii) to the extent that his or her rights to purchase stock
under all employee stock purchase plans of the Company and its Subsidiaries
accrues at a rate which exceeds Twenty-Five Thousand Dollars ($25,000) worth of
stock (determined at the Fair Market Value of a share of Common Stock at the
time such option is granted) for each calendar year in which such option is
outstanding at any time. In the event that an Employee may not be granted an
option under the Plan because of the foregoing restrictions, the Employee shall
be granted an option to purchase the maximum number of shares that would not
violate the foregoing restrictions.

     4.  OFFERING PERIODS AND PURCHASE PERIODS. The Board shall have the power
to change the duration of Offering Periods (including the commencement dates
thereof) with respect to future offerings without stockholder approval if such
change is announced at least five (5) days prior to the scheduled beginning of
the Offering Period to be affected thereafter.

     5.  PARTICIPATION.

         a. An eligible Employee may become a participant in the Plan by
completing a subscription agreement in the form of EXHIBIT A or such other form
as the Company may deem satisfactory and filing it with the Company's payroll
office or such other office as the Company may direct prior to the Enrollment
Date for the applicable Offering Period.

         b. Payroll deductions for a participant shall commence on the first
payroll following the Enrollment Date for the applicable Offering Period and
shall end on the last payroll in such Offering Period, unless sooner terminated
by the participant as provided in Section 9 hereof.

     6.  PAYROLL DEDUCTIONS.

         a. At the time a participant files his or her subscription agreement,
he or she shall elect to have payroll deductions made on each payday during the
Offering Period in an

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amount not exceeding ten percent (10%) of the Compensation which he or she
receives on each payday during the Offering Period.

         b. All payroll deductions made for a participant shall be credited to
his or her account under the Plan and shall be withheld in whole percentages
only. A participant may not make any additional payments into such account.

         c. A participant may discontinue his or her participation in the Plan
as provided in Section 9 hereof, or may increase or decrease the rate of his or
her payroll deductions to not more than ten percent (10%) or less than zero
percent (0%) not more than one (1) time during each Offering Period by
completing or filing with the Company a new subscription agreement authorizing
such change in payroll deduction rate. The Board may, in its discretion,
increase or decrease the number of participation rate changes that may be made
by a participant during any Offering Period. The change in rate shall be
effective with the first full payroll period following the fifth (5th) business
day after the Company's receipt of the new subscription agreement. A
participant's subscription agreement shall remain in effect for successive
Offering Periods unless terminated as provided in Section 9 hereof.

        d. At the time the option is exercised, in whole or in part, or at the
time any of the Company's Common Stock issued under the Plan is disposed of, the
participant must make adequate provision for the Company's federal, state, or
other tax withholding obligations, if any, which arise upon the exercise of the
option or the disposition of the Common Stock. At any time, the Company may, but
shall not be obligated to, withhold from the participant's compensation the
amount necessary for the Company to meet applicable withholding obligations,
including any withholding required to make available to the Company any tax
deductions or benefits attributable to sale or early disposition of Common Stock
by the Employee.

     7.  GRANT OF OPTION. On the Enrollment Date for each Offering Period, each
eligible Employee participating in such Offering Period shall be granted an
option to purchase (at the applicable Purchase Price) up to a whole number of
shares of the Company's Common Stock (the "Option Shares") determined by
multiplying $2,083 by the number of full months in the Offering Period and
dividing the result by the Fair Market Value of a share of Common Stock on the
Enrollment Date (subject to any adjustment pursuant to Section 16), and provided
that such purchase shall be subject to the limitations set forth in Sections
3(b) and 12 hereof. Exercise of the option shall occur as provided in Section 8
hereof, unless the participant has withdrawn pursuant to Section 9 hereof. The
option shall expire on the last day of the Offering Period.

     8.  EXERCISE OF OPTION. Unless a participant withdraws from the Plan as
provided in Section 9 hereof, his or her option for the purchase of shares shall
be exercised automatically on the Exercise Date applicable to the particular
Offering Period, and a number of full shares not exceeding the number of shares
as to which such participant's option is exercisable on such Exercise Date shall
be purchased for such participant at the applicable Purchase Price with the
accumulated payroll deductions in his or her account. No fractional shares shall
be purchased. Any balance remaining in the participant's payroll deduction
account after such Exercise Date shall be automatically refunded to the
participant, except that any balance that is less than the Purchase Price of one
share of Common Stock will be carried forward into the participant's

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payroll deduction account for the following Offering Period, unless the
participant elects not to participate in the following Offering Period under the
Plan, in which case the balance in the participant's account shall be refunded.
During a participant's lifetime, a participant's option to purchase shares
hereunder is exercisable only by him or her.

     9.  WITHDRAWAL.

         a. A participant may withdraw all but not less than all the payroll
deductions credited to his or her account and not yet used to exercise his or
her option under the Plan at any time by giving written notice to the Company in
the form of EXHIBIT B to this Plan; provided that no Employee may withdraw his
or her payroll deductions less than ten (10) Trading Days prior to an Exercise
Date. All of the participant's payroll deductions credited to his or her account
shall be paid to such participant promptly after receipt of notice of withdrawal
and such participant's option for the Offering Period shall be automatically
terminated upon receipt of such notice, and no further payroll deductions from
such participant for the purchase of shares shall be made for such Offering
Period. If a participant withdraws from an Offering Period, payroll deductions
shall not resume at the beginning of the succeeding Offering Period unless the
participant delivers to the Company a new subscription agreement.

         b. A participant's withdrawal from an Offering Period shall not have
any effect upon his or her eligibility to participate in any similar plan which
may hereafter be adopted by the Company or in succeeding Offering Periods.

     10. TERMINATION OF EMPLOYMENT. Upon a participant's ceasing to be an
Employee, for any reason, he or she shall be deemed to have elected to withdraw
from the Plan, such participant's option shall be automatically terminated and
the accumulated payroll deductions credited to such participant's account during
the Offering Period but not yet used to exercise his or her option shall be
returned to such participant or, in the case of his or her death, to the
executor or administrator of the Employee's estate or if no such executor or
administrator has been appointed to the knowledge of the Company, to such other
person(s) as the Company may, in its discretion, designate. If, prior to the
last day of the Offering Period, the Designated Subsidiary by which an Employee
is employed shall cease to be a Subsidiary of the Company, or if the Employee is
transferred to a Subsidiary of the Company that is not a Designated Subsidiary,
the Employee shall be deemed to have terminated employment for the purposes of
this Plan.

     11. INTEREST.  No interest shall accrue on the payroll deductions of a
participant in the Plan.

     12. STOCK.

         a. Subject to adjustment upon changes in capitalization of the Company
as provided in Section 16 hereof, the maximum number of shares of the Company's
Common Stock which shall be made available for sale under the Plan shall be
350,000 shares. If, on a given Exercise Date, the number of shares with respect
to which options are to be exercised exceeds the number of shares then available
under the Plan, the Company shall make a pro rata allocation

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of the shares remaining available for purchase in as uniform a manner as shall
be practicable and as it shall determine to be equitable.

         b. The participant shall have no interest or voting right in shares
covered by his or her option until such option has been exercised.

     13. ADMINISTRATION. The Plan shall be administered by the Board or a
committee of members of the Board appointed by the Board. The Board or its
committee shall have full and exclusive discretionary authority to construe,
interpret and apply the terms of the Plan, to determine eligibility and to
adjudicate all disputed claims filed under the Plan. Every finding, decision and
determination made by the Board or its committee shall, to the full extent
permitted by law, be final and binding upon all parties.

     14. TRANSFERABILITY. Neither payroll deductions credited to a participant's
account nor any rights with regard to the exercise of an option or to receive
shares under the Plan may be assigned, transferred, pledged or otherwise
disposed of in any way (other than by will or the laws of descent and
distribution by the participant). Any such attempt at assignment, transfer,
pledge or other disposition shall be without effect, except that the Company may
treat such act as an election to withdraw funds from an Offering Period in
accordance with Section 9 hereof.

     15. USE OF FUNDS. All payroll deductions received or held by the Company
under the Plan may be used by the Company for any corporate purpose, and the
Company shall not be obligated to segregate such payroll deductions.

     16. ADJUSTMENTS UPON CHANGES IN CAPITALIZATION, DISSOLUTION, LIQUIDATION,
MERGER OR ASSET SALE.

         a. CHANGES IN CAPITALIZATION. Subject to any required action by the
stockholders of the Company, the maximum number of shares of Common Stock
available for sale under the Plan, the Reserves, the maximum number of shares
each participant may purchase during each Offering Period (pursuant to Section
7), as well as the price per share and the number of shares of Common Stock
covered by each option under the Plan which has not yet been exercised, shall be
proportionately adjusted for any increase or decrease in the number of issued
shares of Common Stock resulting from a stock split, reverse stock split, stock
dividend, combination or reclassification of the Common Stock. Such adjustment
shall be made by the Board, whose determination in that respect shall be final,
binding and conclusive. Except as expressly provided herein, no issuance by the
Company of shares of stock of any class, or securities convertible into shares
of stock of any class, shall affect, and no adjustment by reason thereof shall
be made with respect to, the number or price of shares of Common Stock subject
to an option.

         b. DISSOLUTION OR LIQUIDATION. In the event of the proposed dissolution
or liquidation of the Company, the Board shall shorten any Offering Period then
in progress by setting a new Exercise Date (the "NEW EXERCISE DATE"), and such
Offering Period shall terminate on the New Exercise Date. The New Exercise Date
shall be before the date of the Company's proposed dissolution or liquidation.
The Board shall notify each participant in writing, at least ten (10) days prior
to the New Exercise Date, that the Exercise Date for the

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participant's option has been changed to the New Exercise Date and that the
participant's option shall be exercised automatically on the New Exercise Date,
unless prior to such date the participant has withdrawn from the Offering Period
as provided in Section 9 hereof.

          c. MERGER OR ASSET SALE. If the Company shall at any time merge or
consolidate with another corporation and the holders of the capital stock of the
Company immediately prior to such merger or consolidation continue to hold at
least sixty percent (60%) by voting power of the capital stock of the surviving
corporation ("Continuity of Control"), the holder of each option then
outstanding will thereafter be entitled to receive at the next Exercise Date
upon the exercise of such option for each share as to which such option shall be
exercised the securities or property which a holder of one share of Common Stock
was entitled to upon and at the time of such merger or consolidation, and the
Board shall take such steps in connection with such merger or consolidation as
the Board shall deem necessary to assure that the provisions of Section 16(a)
shall thereafter be applicable, as nearly as reasonably may be, in relation to
the said securities or property as to which such holder of such option might
thereafter be entitled to receive thereunder.

     In the event of a merger or consolidation of the Company with or into
another corporation which does not involve Continuity of Control, or which
involves a sale of all or substantially all of the assets of the Company (an
"Acquisition"), while unexercised options remain outstanding under the Plan, all
options outstanding as of the effective date of the Acquisition shall be deemed
assumed or substituted for and each holder of an outstanding option shall be
entitled, upon exercise of such option, to receive in lieu of shares of Common
Stock, shares of such stock or other securities as the holders of shares of
Common Stock received pursuant to the terms of the Acquisition. Notwithstanding
the foregoing, in the event that the acquiring or succeeding corporation (or an
affiliate thereof) does not agree to assume or substitute for the options, then
the Board shall shorten any Offering Period then in progress by setting a New
Exercise Date, and such Offering Period then in progress shall terminate on the
New Exercise Date. The New Exercise Date shall be before the effective date of
the Acquisition. The Board shall notify each participant in writing, at least
ten (10) days prior to the New Exercise Date, that the Exercise Date for the
participant's option has been changed to the New Exercise Date and that the
participant's option shall be exercised automatically on the New Exercise Date,
unless prior to such date the participant has withdrawn from the Offering Period
as provided in Section 9 hereof.

     17.  AMENDMENT OR TERMINATION.

          a. The Board of Directors of the Company may at any time and for any
reason terminate or amend the Plan. Except as provided in Section 16 hereof, no
such termination can affect options previously granted, provided that an
Offering Period may be terminated by the Board of Directors if the Board
determines that the termination of the Plan is in the best interests of the
Company and its stockholders, and upon termination of the Plan all amounts in
the accounts of participating employees shall be promptly refunded. Except as
provided in Section 16 hereof, no amendment may make any change in any option
theretofore granted which adversely affects the rights of any participant
without the consent of the participant. To the extent necessary to comply with
Section 423 of the Code (or any successor rule or provision or any other
applicable law, regulation or stock exchange rule), if applicable,

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the Company shall obtain stockholder approval in such a manner and to such a
degree as required.

          b. Without stockholder consent and without regard to whether any
participant rights may be considered to have been "adversely affected," the
Board (or its committee) shall be entitled to change the Offering Periods, limit
the frequency and/or number of changes in the amount withheld during an Offering
Period, establish the exchange ratio applicable to amounts withheld in a
currency other than U.S. dollars, permit payroll withholding in excess of the
amount designated by a participant in order to adjust for delays or mistakes in
the Company's processing of properly completed withholding elections, establish
reasonable waiting and adjustment periods and/or accounting and crediting
procedures to ensure that amounts applied toward the purchase of Common Stock
for each participant properly correspond with amounts withheld from the
participant's Compensation, and establish such other limitations or procedures
as the Board (or its committee) determines in its sole discretion advisable
which are consistent with the Plan.

     18.  NOTICES. All notices or other communications by a participant to the
Company under or in connection with the Plan shall be deemed to have been duly
given when received in the form specified by the Company at the location, or by
the person, designated by the Company for the receipt thereof.

     19. CONDITIONS UPON ISSUANCE OF SHARES. Shares shall not be issued with
respect to an option unless the exercise of such option and the issuance and
delivery of such shares pursuant thereto shall comply with all applicable
provisions of law, domestic or foreign, including, without limitation, the
Securities Act of 1933, as amended, the Securities Exchange Act of 1934, as
amended, the rules and regulations promulgated thereunder, and the requirements
of any stock exchange upon which the shares may then be listed, and shall be
further subject to the approval of counsel for the Company with respect to such
compliance.

         As a condition to the exercise of an option, the Company may require
the person exercising such option to represent and warrant at the time of
any such exercise that the shares are being purchased only for investment and
without any present intention to sell or distribute such shares if, in the
opinion of counsel for the Company, such a representation is required by any of
the aforementioned applicable provisions of law.

     20. GOVERNMENTAL REGULATIONS. The Company's obligation to sell and deliver
Common Stock under this Plan is subject to listing on an established stock
exchange or quotation on a national market system or an over-the-counter market
(to the extent the Common Stock is then so listed or quoted) and the approval of
all governmental authorities required in connection with the authorization,
issuance or sale of such stock.

     21. GOVERNING LAW. The Plan shall be governed by Massachusetts law except
to the extent that such law is preempted by federal law.

     22. SOURCE OF SHARES. Shares may be issued upon exercise of an option from
authorized but unissued Common Stock, from shares held in the treasury of the
Company, or from any other proper source.

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     23. NOTIFICATION UPON SALE OF SHARES. Each Employee agrees, by entering the
Plan, to promptly give the Company notice of any disposition of shares purchased
under the Plan where such disposition occurs within two years after the date of
grant of the option pursuant to which such shares were purchased.

     24. EFFECTIVE DATE. The Plan shall take effect upon the date of the
Company's initial public offering of its equity securities registered on Form
S-1 with the Securities and Exchange Commission, subject to approval by the
stockholders of the Company. It shall continue in effect for a term of ten (10)
years unless sooner terminated under Section 17 hereof.

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                                    EXHIBIT A

                              THE MEDICINES COMPANY

                        2000 EMPLOYEE STOCK PURCHASE PLAN

                             SUBSCRIPTION AGREEMENT

_______  Original Application                     Enrollment Date:  ____________
_______  Change in Payroll Deduction Rate (Complete only Section 2 and date
and sign).

     1. ______________________________ hereby elects to participate in the The
Medicines Company 2000 Employee Stock Purchase Plan (the "EMPLOYEE STOCK
PURCHASE PLAN") and subscribes to purchase shares of the Company's Common Stock
in accordance with this Subscription Agreement and the Employee Stock Purchase
Plan.

     2. I hereby authorize payroll deductions from each paycheck in the amount
of ____% of my Compensation on each payday (not to exceed ten percent (10%))
during the Offering Period in accordance with the Employee Stock Purchase Plan.
(Please note that no fractional percentages are permitted.)

     3. I understand that said payroll deductions shall be accumulated for the
purchase of shares of Common Stock at the applicable Purchase Price determined
in accordance with the Employee Stock Purchase Plan. I understand that if I do
not withdraw from an Offering Period, any accumulated payroll deductions will be
used to automatically exercise my option.

     4. I have received a copy of the complete Employee Stock Purchase Plan. I
understand that my participation in the Employee Stock Purchase Plan is in all
respects subject to the terms of the Plan.

     5. I understand that if I dispose of any shares received by me pursuant to
the Plan within two years after the Enrollment Date (the first day of the
Offering Period during which I purchased such shares) or one year after the
Exercise Date, I will be treated for federal income tax purposes as having
received ordinary income at the time of such disposition in an amount equal to
the excess of the fair market value of the shares at the time such shares were
purchased by me over the price which I paid for the shares. I HEREBY AGREE TO
NOTIFY THE COMPANY IN WRITING WITHIN 30 DAYS AFTER THE DATE OF ANY DISPOSITION
OF MY SHARES AND I WILL MAKE ADEQUATE PROVISION FOR FEDERAL, STATE OR OTHER TAX
WITHHOLDING OBLIGATIONS, IF ANY, WHICH ARISE UPON THE DISPOSITION OF THE COMMON
STOCK. The Company may, but will not be obligated to, withhold from my
compensation the amount necessary to meet any applicable withholding obligation
including any withholding necessary to make available to the Company any tax
deductions or benefits attributable to sale or early disposition of Common Stock
by me.

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     6. I hereby agree to be bound by the terms of the Employee Stock Purchase
Plan. The effectiveness of this Subscription Agreement is dependent upon my
eligibility to participate in the Employee Stock Purchase Plan.

NAME:  (Please Print) __________________________________________________________
                          (First)          (Middle)              (Last)

___________________________________        _____________________________________
Relationship

                                           _____________________________________
                                           Address

Employee's Social
Security Number:           ____________________________________________________

Employee's Address:        _____________________________________________________

                           _____________________________________________________

                           _____________________________________________________

I UNDERSTAND THAT THIS SUBSCRIPTION AGREEMENT SHALL REMAIN IN EFFECT THROUGHOUT
SUCCESSIVE OFFERING PERIODS UNLESS TERMINATED BY ME.

Dated:  _______________________              ___________________________________
                                             Signature of Employee
                                             (Please print)

                                             ___________________________________
                                             Spouse's Signature (If beneficiary
                                             other than Spouse)

<PAGE>

                                    EXHIBIT B

                              THE MEDICINES COMPANY

                        2000 EMPLOYEE STOCK PURCHASE PLAN

                              NOTICE OF WITHDRAWAL

         The undersigned participant in the Offering Period of The Medicines
Company 2000 Employee Stock Purchase Plan which began on ________________, 2000
(the "ENROLLMENT DATE") hereby notifies the Company that he or she hereby
withdraws from the Offering Period. He or she hereby directs the Company to pay
to the undersigned as promptly as practicable all the payroll deductions
credited to his or her account with respect to such Offering Period. The
undersigned understands and agrees that his or her option for such Offering
Period will be automatically terminated. The undersigned understands further
that no further payroll deductions will be made for the purchase of shares in
the current Offering Period and the undersigned shall be eligible to participate
in succeeding Offering Periods.

                                          Name and Address of Participant:

                                          ______________________________________

                                          ______________________________________

                                          ______________________________________

                                          Signature:

                                          ______________________________________

                                          Date:_________________________________<PAGE>
                             UNIT PURCHASE AGREEMENT

                  UNIT PURCHASE AGREEMENT (this "Agreement"), dated as of April
         1, 1998, by and among HYBRIDON, INC., a Delaware corporation (the
         "Company") and the Persons listed on the signature pages hereof (the
         "Current Purchasers") and such other Persons that from time to time
         hereafter may become party hereto pursuant to Section 13.10, (the
         "Additional Purchasers" and collectively with the Current Purchasers,
         the "Purchasers").

         The Company desires to issue and sell to Purchasers, and Purchasers
desire to purchase from the Company, units consisting of an aggregate of up to
$55,000,000 aggregate principal amount of Notes due 2007 (the "Notes") in
substantially the form attached hereto as EXHIBIT A, together with certain
warrants to purchase common stock of the Company (the "Note Units") or, if the
Alternative Equity Closing Conditions referred to in Supplement #2 (as defined
in Section 6.5) are met, the Alternative Equity Units referred to therein (the
sale of such Alternative Equity Units being referred to herein as the
"Alternative Offering"), upon and subject to the terms and conditions
hereinafter set forth. As used herein, the terms "Unit Offering" and "Offering"
shall mean the offering of Units by the Company during the Offering Period
hereinafter referred to pursuant to this Agreement and substantially similar
agreements, and the Unit Purchase Agreements in respect of Note Units previously
entered into, and "Units" shall mean the Note Units or the Alternative Equity
Units, as applicable.

         Accordingly, in consideration of the premises and the mutual agreements
contained herein, Purchasers and the Company hereby agree as follows:

         1.       PURCHASE AND SALE OF THE UNITS.

                  1.1. PURCHASE AND SALE OF THE UNITS. Subject to the terms and
conditions set forth herein, the Company hereby agrees to issue and sell to
Purchasers, and Purchasers, severally and not jointly, hereby agree to purchase
from the Company, units ("Units"), each consisting, except as otherwise provided
in the first paragraph of this Agreement in respect of the Alternative Offering,
of (i) $100,000 principal amount of Notes and (ii) Equity Warrants in accordance
with Section 2.2 hereof, at a Closing (as such term is defined in Section 2.1
hereof), provided however, that upon the occurrence of the Mandatory Conversion
Event (as defined in the Note), Units will consist of the Series B Preferred
Stock that would otherwise underlie such Notes and such Equity Warrants. The
aggregate purchase price for the respective Units sold to each Purchaser
pursuant to this Agreement shall be the product of (x) the aggregate number of
Units purchased by such Purchaser set forth on the signature page hereto
executed by such Purchaser and (y) $100,000. "Operative Documents" as used
herein shall mean this Agreement, the Notes, the Certificate of Designation for
the Series B Preferred Stock of the Company in substantially the form attached
hereto as EXHIBIT B (the "Certificate of Designation") (such Preferred Stock,
the "Conversion Securities"), the Warrant Agreement in substantially the form

<PAGE>

attached hereto as EXHIBIT C-1, the Alternative Equity Warrant Agreement in
substantially the form attached hereto as EXHIBIT C-2, and the Negative Pledge
Agreement in substantially the form attached hereto as EXHIBIT D.

                  1.2. REGULATION D OFFERING. The Company has retained placement
agents to conduct, on a "best efforts" basis, a private placement offering of
the Units in the United States in reliance on Regulation D (the "Regulation D
Offering").

                  1.3. REGULATION S OFFERING. The Company has retained Pillar
Investments Ltd. ("Pillar"), as placement agent (the "Placement Agent" and,
together with any placement agent for the Regulation D Offering, the "Placement
Agents"), to conduct, on a "best efforts" basis, a private placement offering of
the Units in reliance on Regulation S (the "Regulation S Offering") for sale
outside of the "United States" (as defined in Section 11.26 hereof).

        2.       DELIVERY OF UNITS.

                  2.1. DELIVERY OF UNITS.

                  (a) The Company shall offer for sale a minimum of 20 Units
(the "Minimum Offering Amount") and an aggregate maximum of up to 400 Units (the
"Maximum Offering Amount") (with an option (the "Placement Agents' Option") in
favor of the Placement Agents for an additional 150 Units (plus warrants to be
sold to the Placement Agents or their designees, for $0.01 per warrant, to
purchase Units equal, in the aggregate, to 25% of the Units sold in the Unit
Offering), except that, in the case of the Alternative Offering, the contrary
information in Supplement #2 (as defined in Section 6.5) shall supersede the
foregoing. Each Purchaser understands and acknowledges that such Purchaser has
no discretion as to the receipt of Note Units or Alternative Equity Units; the
securities constituting the Units will be determined based solely on whether the
Alternative Equity Closing Conditions described in Supplement #2 have been
satisfied. The offering period (the "Offering Period") for the Units in the
Regulation S Offering began on January 15, 1998. The Company may conduct
closings of Units (each, a "Closing") on an interim basis until the Maximum
Offering Amount (and any additional amount, pursuant to the Placement Agents'
Option) has been reached (the "Final Closing Date"; such term as used herein
also referring to the closing date of the Alternative Offering). The Offering
Period shall terminate at 12:00 noon (New York Time) on October 15, 1998,
subject to extension at the sole option of the Placement Agents, for an
additional 60 days (the "Termination Date").

                  (b) Contemporaneously with the execution and delivery of this
Agreement by a Purchaser and pending the sale of Units at a Closing, such
Purchaser will be required to deposit the Purchase Price in escrow with the
Escrow Agent (as defined in the Escrow Agreement hereinafter referred to) by
wire transfer of immediately available funds for the account of the Escrow Agent
to "MeesPierson (Cayman) Limited, Escrow Agent, F/B/O Hybridon, Inc," pursuant
to the terms of an escrow agreement in substantially the forms attached hereto
as EXHIBIT E (the "Escrow Agreement").

                                     - 2 -
<PAGE>

                  (c) At a Closing, the funds required for the purchase of the
Units by respective Purchasers will be released by the Escrow Agent from the
escrow account in accordance with the terms of the Escrow Agreement. The Company
will promptly deliver to Purchasers the Notes or Common Stock underlying the
Units to be purchased on the date of a Closing as set forth in Article 1 hereof
against the receipt by the Company of the Purchase Price from escrow in
accordance with the Escrow Agreement. Each Purchaser hereby authorizes the
Placement Agent to accept delivery of Notes (or other securities underlying
Units) or certificates representing Common Stock on such Purchaser's behalf in
Paris, France unless the Purchaser is in attendance at such Closing. The Notes
shall be registered in the Purchasers' respective names or the name of the
nominee(s) of such Purchasers in denominations of $1,000 and integral multiples
thereof pursuant to instructions delivered to the Company not less than two days
prior to a Closing. Interest on each Note sold in the Unit Offering shall accrue
only from the date of issuance of such Note.

                  (d) Each Closing of the purchase and sale of the Units in the
Regulation S Offering will take place at the offices of the Placement Agent at
28, Avenue de Messine, 75008 Paris, France. Any Unit to be sold by the Company
under this Agreement must be sold outside of the United States.

                  2.2. EQUITY WARRANTS. Promptly following the Termination Date
or at such earlier time as shall be determined by the Placement Agent, each
Purchaser shall be entitled to be issued Unit Warrants (as defined below) as
follows. All Units sold in the Offering will contain Unit Warrants (as defined
below) to purchase up to the number of shares of Common Stock equal to 15%
(rounded to the nearest whole share) of the number of shares of Common Stock
underlying the Conversion Securities (as defined below) underlying the principal
amount of Notes included in the number of Units purchased by such Purchaser in
the Offering (or underlying the Conversion Securities sold directly) (such
number of shares of Common Stock, the "Common Equivalent Shares"). In addition,
Units purchased prior to the date on which the Mandatory Conversion Event (as
defined in the Note) occurs will contain Unit Warrants permitting the purchase
of up to an additional 5 % of the Common Equivalent Shares (rounded to the
nearest whole share). "Unit Warrants" shall mean warrants exercisable for a
period of seven years from the Final Closing Date (as defined below) at an
initial exercise price equal to the conversion price per share of Common Stock
of the Conversion Securities as in effect on the Final Closing Date. The terms
of the Unit Warrants shall be as more fully described in the Warrant Agreement
between the Company and ChaseMellon Shareholder Services LLC, as Warrant Agent
(the "Warrant Agreement"), a form of which is attached hereto as EXHIBIT C.

                                     - 3 -
<PAGE>

Furthermore, in the event that the Mandatory Conversion Event does not occur on
or before the Termination Date, each Purchaser shall be entitled to receive
additional warrants (the "Additional Warrants") to purchase, at an exercise
price of $.001 per share of Common Stock, a number of shares of Common Stock
equal to 100% (rounded to the nearest whole share) of the Common Equivalent
Shares underlying the Units purchased by such Purchaser in the Offering, which
Additional Warrants will be exercisable immediately; provided, however, that if
by the Termination Date the Company has received proceeds, net of cash fees,
commissions and expenses, of at least $20,000,000 but the Exchange Offer has not
been open until the expiration of 20 (or, if required by law, 30) business days
(i.e., the minimum period required by Federal law), such Additional Warrants
will be exercisable beginning on the first day following the end of such
statutory period unless the Mandatory Conversion Event (as defined in the Note)
has occurred. After the occurrence of any Mandatory Conversion Event, upon the
occurrence of a Reset Event (as defined in the Certificate of Designation), each
Purchaser shall be issued additional Unit Warrants to purchase the number of
shares of Common Stock equal to 50% of the product of (x) the number of
Conversion Securities held of record by such Purchaser at such time, multiplied
by (y) the difference between (1) the Conversion Rate (as defined in the
Certificate of Designation) immediately following the Reset Event minus (2) the
Conversion Rate immediately preceding the Reset Event. The Company shall not be
required to issue any fractional shares upon exercise of the Unit Warrants or
the Additional Warrants (collectively, the "Equity Warrants") or pay any cash in
lieu thereof. Notwithstanding the foregoing, so long as any 9% Notes due 2004
("9% Notes") of the Company remain outstanding, warrantholders may not exercise
Equity Warrants to the extent that such exercise could, in the Company's
judgment, either alone or in conjunction with other issuances or holdings of
capital stock, other warrants or convertible securities of the Company, result
in a Change of Control (as defined in the Indenture referred to in the Note). In
the event of the Alternative Offering, in lieu of the foregoing, Purchasers will
be entitled to the Alternative Equity Warrants described in Supplement #2.

        3. CONDITIONS TO THE OBLIGATIONS OF PURCHASERS AT A CLOSING. The
obligation of Purchasers to purchase and pay for the Units to be purchased
by Purchasers at a Closing is subject to the satisfaction on or prior to the
relevant Closing Date of the following conditions, which may only be waived by
written consent of the Placement Agent.

                  3.1. REPRESENTATIONS AND WARRANTIES. The representations and
warranties of the Company contained in this Agreement shall be true and correct
in all material respects when made, and shall be true and correct in all
material respects at and as of the date of such Closing as if they had been made
on and as of such Closing.

                  3.2. PERFORMANCE OF COVENANTS. All of the covenants and
agreements of the Company contained in this Agreement and required to be
performed on or prior to the relevant

                                     - 4 -
<PAGE>

Closing Date shall have been performed in a manner reasonably satisfactory to
the Secured Party.

                  3.3. CLOSING DOCUMENTS. The Company shall have delivered to
the Placement Agent the following:

                  (a) a certificate executed by the President or Chief Executive
Officer of the Company dated the relevant Closing Date stating that the
conditions set forth in Sections 3.1 and 3.2 have been satisfied; and

                  (b) a certificate of the Secretary or Assistant Secretary of
the Company, dated the relevant Closing Date, certifying the attached copy of
the By-laws of the Company, the authorization of the execution, delivery and
performance of this Agreement, and the resolutions authorizing the actions to be
taken by the Company under this Agreement.

                  3.4. NEGATIVE PLEDGE. Except in the case of the Alternative
Offering, the Company shall have entered into the Negative Pledge Agreement with
the Secured Party on behalf of Purchasers, in substantially the form of EXHIBIT
D hereto, covering the intellectual property of the Company.

                  3.5. NO LEGAL ORDER PENDING. There shall not then be in effect
any legal or other order enjoining or restraining the transactions contemplated
by this Agreement.

                  3.6. NO LAW PROHIBITING OR RESTRICTING SUCH SALE. There shall
not be in effect any law, rule or regulation prohibiting or restricting such
sale or requiring any consent or approval of any person which shall not have
been obtained to issue the Units (except as otherwise provided in this
Agreement).

                  3.7. [Reserved]

                  3.8. LEGAL OPINION. If requested by the Placement Agent at a
Closing, counsel to the Company shall have delivered to the Placement Agent for
the benefit of such Placement Agent and the Purchasers at such Closing, a legal
opinion concerning legal matters relating to this Agreement and the Term Sheet
as the Placement Agent may require.

                  3.9. COMFORT LETTER. If requested by the Placement Agent at a
Closing, the Company's auditors, Arthur Andersen LLP, shall have delivered to
the Placement Agent for the benefit of the Placement Agent and the Purchasers at
such Closing, a comfort letter to such effect as the Placement Agent may
require.

                                     - 5 -

<PAGE>

                  3.10. PROCEEDINGS. All corporate and other proceedings taken
or to be taken in connection with the transactions contemplated hereby to be
consummated at each Closing and all documents incident thereto shall be
reasonably satisfactory in form and substance to the Secured Party, including
but not limited to the authorization of the issuance of the Conversion
Securities, Equity Warrants, Placement and Advisory Warrants (as defined in
Section 11.11) and the Unit-Underlying Common Stock (as defined in Section
11.24).

        4. CONDITIONS TO THE OBLIGATIONS OF THE COMPANY AT A CLOSING. The
obligation of the Company to issue and sell Units to Purchasers at a Closing
is subject to the satisfaction of the following conditions, each of which may be
waived by the Company:

                  4.1. REPRESENTATIONS AND WARRANTIES. The representations and
warranties of each Purchaser contained in this Agreement shall be true and
correct when made, and shall be true and correct at and as of the date of such
Closing as if they had been made on and as of such Closing.

                  4.2. NO LAW PROHIBITING OR RESTRICTING SUCH SALE. There shall
not be in effect any law, rule or regulation prohibiting or restricting such
sale or requiring any consent or approval of any person which shall not have
been obtained to issue the Notes, if the Closing consists of Note Units and
Common Stock, if the Closing consists of Alternative Equity Units (except as
otherwise provided in this Agreement).

        5. CREATION OF SECURITY INTEREST.

                  5.1. GRANT OF SECURITY INTEREST.

                  (a) The Company hereby grants and pledges to Amer Tabbah (or
his designee) (the "Secured Party"), solely as agent for Purchasers and not in
his individual capacity, a continuing security interest in all presently
existing and hereafter acquired or arising assets and property of the Company
described on EXHIBIT F hereto (the "Collateral") in order to secure prompt
payment of the principal sum and interest evidenced by the Notes, and the
performance by the Company of each of its obligations under this Agreement and
the Notes. Such security interest shall automatically terminate upon the earlier
of (i) the payment of principal and interest on the Notes and (ii) such time as
the Notes are no longer outstanding (the "Security Interest Termination Date").
Purchasers hereby acknowledge and agree that the security interests granted
hereby are subordinate and subject to any prior security interest in the
Collateral granted by the Company and are subordinate and subject to any lien
granted in the future to secure Senior Indebtedness of the Company. Purchasers
and the Secured Party hereby agree not to exercise any of their rights with
respect to the Collateral under this Agreement, at law, in equity or otherwise
until the holders of Senior Indebtedness have been paid in full.

                                     - 6 -
<PAGE>

                  (b) Purchasers, by their acceptance of the benefits of this
Agreement and the Notes, hereby irrevocably designate the Secured Party to act
as Secured Party with respect to this Agreement and as specified in the other
Operative Documents. Each Purchaser hereby irrevocably authorizes, and each
holder of any Note, by such holder's acceptance of such Note, shall be deemed
irrevocably to authorize, the Secured Party to take such action on its behalf
under the provisions of this Agreement and the other Operative Documents and any
other instruments and agreements referred to herein or therein and to exercise
such powers and to perform such duties hereunder and thereunder as are
specifically delegated to, or required of, the Secured Party by the terms hereof
or thereof and such other powers as are reasonably incidental thereto. Each
Purchaser, on behalf of itself and future holders of the Notes issued to such
Purchaser, hereby authorizes and directs the Secured Party, from time to time in
the Secured Party's discretion to take any action and promptly to execute and
deliver on its behalf any document or instrument that the Company may reasonably
request to effect, confirm or evidence the provisions of this Article 5,
including, without limitation, the occurrence of the Security Interest
Termination Date, any subordination agreement, or otherwise. In addition,
Purchasers and Secured Party hereby covenant and agree promptly to execute and
deliver any such document or instrument in respect of such subordination, and in
respect of the occurrence of the Security Interest Termination Date, as the
Company may reasonably request.

                  (c) This Section 5 shall be inapplicable in the case of the
Alternative Offering.

                  5.2. DELIVERY OF ADDITIONAL DOCUMENTATION REQUIRED. The
Company shall from time to time execute and deliver to Secured Party, at the
request of Secured Party, all financing statements and other documents that
Secured Party may reasonably request to perfect and continue perfected Secured
Party's security interests in the Collateral and in order fully to consummate
all of the transactions contemplated under this Agreement, it being understood
and agreed by the Purchasers and the Secured Party that the Company need not
deliver possession of any Collateral to the Secured Parry, take any action to
perfect the security interest granted hereby other than the filing of financing
statements under the Uniform Commercial Code or take any other action that
would, in its sole judgment, conflict with the terms of or pertaining to any
Senior Indebtedness.

         6. REPRESENTATIONS AND WARRANTIES OF PURCHASERS. Purchasers hereby
severally represent and warrant to the Company as follows (for purposes
of the Alternative Offering, "Notes" and "Conversion Securities" shall refer to
Common Stock, and "Equity Warrants" shall refer to Alternative Equity Warrants
unless the context shall otherwise require):

                  6.1. INVESTMENT INTENT. Each Purchaser recognizes that the
purchase of the Units involves a high degree of risk including, but not limited
to, the following: (i) the Company remains a development stage business with
limited operating history and requires substantial

                                     - 7 -
<PAGE>

funds in addition to the proceeds of the Unit Offering; (ii) an investment
in the Company is highly speculative, and only investors who can afford
the loss of their entire investment should consider investing in the
Company, the Units, the Notes, the Equity Warrants, or the shares of Conversion
Securities of the Company issued on conversion of, or in lieu of, the Notes or
the Unit-Underlying Common Stock, (iii) such Purchaser may not be able to
liquidate his investment; (iv) transferability of the Notes, the Equity
Warrants, any shares of Conversion Securities of the Company which may be issued
upon conversion of, or in lieu of, the Notes and the Unit Underlying Common
Stock is extremely limited; (v) in the event of a disposition of the Notes, the
Equity Warrants, the Conversion Securities or the Unit-Underlying Common Stock,
such Purchaser could sustain the loss of his entire investment and (vi) the
Company has not paid any dividends since inception and does not anticipate the
payment of dividends on the Common Stock or the Conversion Securities in the
foreseeable future. Such risks are more fully set forth in the Term Sheet (as
hereinafter defined) furnished by the Company to such Purchaser.

                  6.2. LACK OF LIQUIDITY. Each Purchaser confirms that he or it
is able (i) to bear the economic risk of this investment, (ii) to hold the
Notes, the Equity Warrants, any shares of Conversion Securities of the Company
issued upon conversion of, or in lieu of, the Notes and any shares of
Unit-Underlying Common Stock for an indefinite period of time, and (iii)
presently to afford a complete loss of his or its investment; and represents
that he or it has sufficient liquid assets so that the illiquidity associated
with this investment will not cause any undue financial difficulties or affect
such Purchaser's ability to provide for his or its current needs and possible
financial contingencies, and that his or its commitment to all speculative
investments is reasonable in relation to his or its net worth and annual income.
Furthermore, each Purchaser acknowledges that the Equity Warrants and the
Conversion Securities contain certain restrictions on exercise, voting,
conversion and certain other rights, as more particularly set forth in the
Warrant Agreement and the Certificate of Designation for the Conversion
Securities, attached hereto as EXHIBITS C and B, respectively.

                  6.3. KNOWLEDGE AND EXPERIENCE. Each Purchaser hereby
acknowledges and represents that such Purchaser has prior investment experience,
including investment in securities that are non-listed, unregistered and are not
traded on the Nasdaq National or SmallCap Market, nor on the National
Association of Securities Dealers, Inc.'s (the "NASD ") automated quotation
system, or such Purchaser has employed at its own expense the services of an
investment advisor, attorney and/or accountant to request documents from the
Company pursuant to Section 6.5 hereof and to read all of the documents
furnished or made available by the Company to such Purchaser and to evaluate the
investment, tax and legal merits and the consequences and risks of such a
transaction on such Purchaser's behalf, that such Purchaser or such professional
advisor has such knowledge and experience in financial and business matters and
that such Purchaser or such professional advisor is capable of evaluating the
merits and risks

                                     - 8 -
<PAGE>

of the prospective investment and, if applicable, satisfies the conditions set
out in Rule 501(h) under the Securities Act.

                  6.4. PURCHASER CAPACITY. Each Purchaser hereby represents that
such Purchaser either by reason of such Purchaser's business or financial
experience, or the business or financial experience of such Purchaser's
professional advisors (who are unaffiliated with, and who are not compensated
by, the Company or any affiliate or selling agent of the Company, including the
Placement Agent, directly or indirectly), has the capacity to protect such
Purchaser's own interests in connection with the transaction contemplated
hereby.

                  6.5. TERM SHEET. Each Purchaser hereby acknowledges receipt
and careful review of (a) the Confidential Term Sheet of the Company attached
hereto as EXHIBIT G-1 and Supplement #1 thereto attached hereto as EXHIBIT G-2
("Supplement #1") and Supplement #2 thereto attached hereto as EXHIBIT G-3
("Supplement #2"), as they may be further supplemented and amended, and the
attachments and exhibits thereto, all of which constitute an integral part
thereof (the "Term Sheet"), and (b) this Agreement and all attachments to it,
and hereby represents that such Purchaser has been furnished by the Company
during the course of this transaction with all information regarding the Company
which such Purchaser or its representative has requested or desired to know, has
been afforded the opportunity to ask questions of, and to receive answers from,
duly authorized officers or other representatives of the Company concerning the
terms and conditions of the Unit Offering, securities underlying the Units, the
Conversion Securities and the Unit-Underlying Common Stock and the affairs of
the Company and has received any additional information which such Purchaser or
its representative has requested.

                  6.6. RELIANCE ON INFORMATION. Each Purchaser has relied solely
upon the information provided by the Company in the Term Sheet and in this
Agreement in making the decision to invest in the Units. To the extent
necessary, each Purchaser has retained, at the sole expense of such Purchaser,
and relied upon, appropriate professional advice regarding the investment, tax
and legal merits and consequences of this Agreement and its purchase of the
Units, the Notes, the Equity Warrants, the conversion of the Notes into, or the
purchase of, the Conversion Securities and the conversion into or exercise for
Unit-Underlying Common Stock hereunder. Each Purchaser acknowledges and agrees
that (i) the Company has prepared the Term Sheet and that no other Person,
including, without limitation, any of the Placement Agents, has supplied any
information for inclusion in the Term Sheet other than information furnished in
writing to the Company by the Placement Agents specifically for inclusion in the
Term Sheet relating to such respective placement agent, (ii) the Placement
Agents have no responsibility for the accuracy or completeness of the Term Sheet
and (iii) such Purchaser has not relied upon the independent investigation or
verification, if any, which may have been undertaken by the Placement Agents.

                                     - 9 -
<PAGE>

                  6.7. NO SOLICITATION. Each Purchaser represents that (i) such
Purchaser was contacted regarding the sale of the Units by the Placement Agent
(or an authorized agent or representative thereof) with whom such Purchaser had
a prior substantial pre-existing relationship and (ii) no Units were offered or
sold to such Purchaser by means of any form of general solicitation or general
advertising, and in connection therewith no Purchaser (A) received or reviewed
any advertisement, article, notice or other communication published in a
newspaper or magazine or similar media or broadcast over television or radio
whether closed circuit, or generally available; or (B) attended any seminar
meeting or industry investor conference whose attendees were invited by any
general solicitation or general advertising.

                  6.8. REGISTRATION. Each Purchaser hereby acknowledges that the
Unit Offering has not been reviewed by the Securities and Exchange Commission or
any state regulatory authority, since the Unit Offering is intended to be exempt
from the registration requirements of Section 5 of the Securities Act pursuant
to Regulation S. No Purchaser shall sell or otherwise transfer the Units, the
Notes, the Conversion Securities, the Equity Warrants or any Unit Underlying
Common Stock unless such securities are registered under the Securities Act or
unless an exemption from such registration is available.

                  6.9. PURCHASE FOR OWN ACCOUNT. Each Purchaser understands that
neither the Units nor the Notes nor the Equity Warrants nor any shares of
Conversion Securities issued or issuable upon conversion of, or in lieu of, the
Notes nor any shares of Unit-Underlying Common Stock have been registered under
the Securities Act by reason of a claimed exemption under the provisions of the
Securities Act which depends, in part, upon such Purchaser's investment
intention. In this connection, each Purchaser hereby represents that such
Purchaser is purchasing Units for such Purchaser's own account for investment
and not with a view toward the resale or distribution to others or for resale in
connection with, any distribution or public offering (within the meaning of the
Securities Act), nor with any present intention of distributing or selling the
same and such Purchaser has no present or contemplated agreement, undertaking,
arrangement, obligation or commitment providing for the disposition thereof. No
Purchaser, if an entity, was formed for the purpose of purchasing the Units.

                  6.10. HOLDING PERIOD. Each Purchaser understands that there is
no public market for the Notes, the Equity Warrants or any shares of the
Conversion Securities issued upon conversion of the Notes and that no market is
expected to develop for any such Notes, such Equity Warrants or such shares.
Each Purchaser understands that even if a public market develops for such Notes,
such Equity Warrants or such shares, reliance upon Rule 144 under the Securities
Act for resales requires, among other conditions, a one-year holding period
prior to the resale (in limited amounts) of securities acquired in a non-public
offering without having to satisfy the registration requirements under the
Securities Act. Each Purchaser understands and hereby acknowledges that the
Company is under no obligation to register any of the Notes, any

                                     - 10 -
<PAGE>

Equity Warrants or any shares of the Conversion Securities under the
Securities Act or any applicable non-United States, state securities or
"blue sky" laws (but will be required to register the Common Stock included
in the Alternative Equity Units). Each Purchaser shall hold the Company and its
directors, officers, employees, controlling persons and agents (including the
Placement Agents and their respective officers, directors, employees, counsel,
controlling persons and agents) and their respective heirs, representatives,
successors and assigns harmless from, and shall indemnify them against, all
liabilities, costs and expenses incurred by them as a result of (i) any
misrepresentation made by such Purchaser contained in this Agreement (including
in Article 14 hereof), (ii) any sale or distribution by such Purchaser in
violation of the Securities Act or any applicable non-United States, state
securities or "blue sky" laws or (iii) any untrue statement made by such
Purchaser.

                  6.11. LEGENDS. Each Purchaser consents to the placement of the
legend set forth below on any certificate or other document evidencing the
Notes:

         "THE TERMS OF THIS NOTE ARE SUBJECT TO THE TERMS OF A UNIT PURCHASE
         AGREEMENT, A COPY OF WHICH IS AVAILABLE FROM HYBRIDON, INC. (THE
         "COMPANY"). THE SECURITIES REPRESENTED BY THIS NOTE HAVE NOT BEEN
         REGISTERED UNDER THE UNITED STATES SECURITIES ACT OF 1933, AS AMENDED
         (THE "SECURITIES ACT"), OR ANY APPLICABLE STATE SECURITIES LAWS, AND
         MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED OR HYPOTHECATED OR OTHERWISE
         TRANSFERRED IN THE ABSENCE OF A REGISTRATION STATEMENT IN EFFECT WITH
         RESPECT TO THE SECURITIES UNDER THE SECURITIES ACT OR AN EXEMPTION FROM
         THE SECURITIES ACT. ANY SUCH TRANSFER MAY ALSO BE SUBJECT TO COMPLIANCE
         WITH APPLICABLE STATE SECURITIES LAWS AND THE LAWS OF OTHER APPLICABLE
         JURISDICTIONS."

Each Purchaser further consents to the placement of one or more restrictive
legends on the shares of Conversion Securities, the Equity Warrants, Common
Stock and the Unit-Underlying Common Stock as required by applicable securities
laws. Each Purchaser is aware that the Company will make a notation in its
appropriate records with respect to the restrictions on the transferability of
such Notes, Equity Warrants, Conversion Securities and Unit-Underlying Common
Stock.

                  6.12. FINANCIAL REVIEW. Each Purchaser understands that the
Company will review this Agreement and is hereby given authority by each
Purchaser to call such Purchaser's bank or place of employment or otherwise
review the financial standing of such Purchaser; and it is further agreed that
the Company (with the consent of the Placement Agent) and the Placement

                                     - 11 -
<PAGE>

Agent, at its sole discretion, reserves the unrestricted right, without further
documentation or agreement on the part of such Purchaser, to reject or limit any
purchase, and to close the Unit Offering to such Purchaser at any time.

                  6.13. RESIDENCE OF PURCHASER. Each Purchaser hereby represents
that the address of such Purchaser furnished by such Purchaser on the signature
page hereof is such Purchaser's principal residence if such Purchaser is an
individual or its principal business address if it is a corporation or other
entity.

                  6.14. POWER AND AUTHORITY. Each Purchaser represents that such
Purchaser has full power and authority (corporate, statutory and otherwise) to
execute and deliver this Agreement and to purchase the Units, the Equity
Warrants, the Notes, the shares of Conversion Securities issuable upon
conversion of, or in lieu of, the Notes and any shares of Unit Underlying Common
Stock. This Agreement constitutes the legal, valid and binding obligation of
each Purchaser, enforceable against such Purchaser in accordance with its terms.

                  6.15. PLANS. If a Purchaser is a corporation, partnership,
limited liability company, trust, employee benefit plan, individual retirement
account or other entity, then subject to the terms contained in this Agreement
(a) it is authorized and qualified to become an investor in the Company and the
person signing this Agreement on behalf of such entity has been duly authorized
by such entity to do so, and (b) it is duly organized, validly existing and in
good standing under the laws of the jurisdiction of its organization.

                  6.16. NASD. Each Purchaser acknowledges that if he or she is a
registered representative of an NASD member firm, he or she must give such firm
the notice required by the NASD's Rules of Fair Practice, receipt of which must
be acknowledged by such firm in Section 14.3 below.

                  6.17. SECURITIES LAWS. Each Purchaser acknowledges that at
such time, if ever, as the Notes, the Equity Warrants, Conversion Securities,
the Common Stock or Unit Underlying Common Stock are registered, sales of the
Notes, the Equity Warrants the Conversion Securities and Unit-Underlying Common
Stock will be subject to applicable nonUnited States and state securities laws,
including those of the State of New Jersey which require any securities sold in
New Jersey to be sold through a registered broker-dealer or in reliance upon an
exemption from registration.

                  6.18. BROKERS. Each Purchaser represents and warrants that it
has not engaged, consented to nor authorized any broker, finder or intermediary
to act on its behalf, directly or indirectly, as a broker, finder or
intermediary in connection with the transactions contemplated by this Agreement.
Each Purchaser shall indemnify and hold harmless the Company from and

                                     - 12 -
<PAGE>

against all fees, commissions or other payments owing to any such person or
firm acting on behalf of such Purchaser hereunder.

                  6.19. PLACEMENT AGENT. Each Purchaser acknowledges that (a)
the Company has engaged, consented to and authorized the Placement Agent in
connection with the transactions contemplated by this Agreement, (b) the Company
shall pay the Placement Agents certain advisory and restructuring fees and a
commission and reimburse the Placement Agents' expenses in accordance with their
respective placement agency agreements, and the Company shall indemnify and hold
harmless such Purchaser from and against all fees, commissions or other payments
owing by the Company to the Placement Agents or any other person or firm acting
on behalf of the Company hereunder and (c) registered representatives of the
Placement Agents and/or their respective designees (including, without
limitation, registered representatives of the Placement Agents and/or their
respective designees who participate in the Unit Offering or in the issuance of
shares of the Conversion Securities upon conversion of the Notes) will be paid a
portion of the commissions paid to the relevant placement agent including a
portion of the Placement and Advisory Warrants (as defined in Section 11.11
hereof).

                  6.20. BENEFICIAL OWNER. Each Purchaser, whose name appears on
the signature line below, will be the beneficial owner of the Units that such
Purchaser acquires.

                  6.21. ACCREDITED INVESTOR. Each Purchaser represents that it
is an "accredited investor" as such term is defined in Rule 501 of Regulation D.

                  6.22. RELIANCE ON REPRESENTATION AND WARRANTIES. Each
Purchaser understands that the Units are being offered and sold to the
undersigned in reliance on speck exemptions from the registration requirements
of United States Federal and state securities laws and that the Company is
relying upon the truth and accuracy of the representations, warranties,
agreements, acknowledgments and understandings of the undersigned set forth
herein in order to determine the applicability of such exemptions and the
suitability of the undersigned to acquire the Notes, the Equity Warrants, the
Conversion Securities, the Common Stock and the Unit-Underlying Common Stock.

                  6.23. LOCK-UP PERIOD. Subject to the proviso below, and to
Section 7.1(c), from the date hereof and continuing for a period (the "Lock-Up
Period") of nine (9) months from the effective date of the Registration
Statement (as defined in Section 12.2 hereof) (the "Effective Date"), each
Purchaser shall not, without the prior written consent of the Placement Agent,
offer, pledge, sell, contract to sell, grant any option for the sale of, or
otherwise dispose of, directly or indirectly, 75% of the Registrable

                                     - 13 -
<PAGE>

Securities (as defined in Section 12.1) purchased or acquired by each
Purchaser, provided, however, that, following each three month period after
the Effective Date, an amount of Registrable Securities equal to 25% of
the number of Registrable Securities purchased or acquired by each Purchaser
shall become exempt from the lock-up provisions contained in this sentence. For
the sake of clarity, subject to Section 7.1(c), 25 % of the Registrable
Securities will not be subject to any lock-up. All percentages referred to above
apply separately to the Common Stock included in, and Common Stock underlying
the warrants included in, the Alternative Equity Units. In addition, each
Purchaser agrees that during the period from the date that such Purchaser was
first contacted with respect to the potential purchase of Transfer Restricted
Securities through the last date upon which such Purchaser holds any Transfer
Restricted Securities (as defined in Section 12.1) or Registrable Securities,
such Purchaser shall not, directly or indirectly, through related parties,
affiliates or otherwise, (i) sell "short" or "short against the box" (as those
terms are generally understood) any security of the Company or (ii) otherwise
engage in any transaction, except for any transaction contemplated by this
Agreement, that involves hedging of such Purchaser's position in any security of
the Company.

                  6.24. CONVERSION SECURITIES CERTIFICATES. Each Purchaser
consents to the placement of a statement on the face or back of any certificates
representing Conversion Securities, in substantially the following form:

         "Hybridon, Inc. (the "Corporation") will furnish without charge to each
         stockholder who so requests the powers, designations, preferences and
         relative, participating, optional, or other special rights of each
         class of stock or series thereof and the qualifications, limitations or
         restrictions of such preferences and/or rights."

         7.       ADDITIONAL REPRESENTATIONS AND WARRANTIES RELATING TO
REGULATION S.

                  7.1. Each Purchaser hereby additionally represents and
warrants to the Company as follows:

                  (a) such Purchaser is not a U.S. Person or a Person. in the
United States, is purchasing the Units for such Purchaser's own account and is
not acquiring the securities comprising, or the securities underlying, the Units
(collectively, the "Securities") for the account or benefit of any U.S. Person;

                  (b) such Purchaser understands and acknowledges that (i) none
of the Securities have been registered under the Securities Act and that the
Securities may not be offered or sold in the United States or to, or for the
account or benefit of, any 'U.S. Person unless the Securities are registered
under the Securities Act or such offer or sale is made pursuant to an exemption
from the registration requirements of the Securities Act, (ii) the Units are
being distributed pursuant to the terms of Regulation S, which permits
securities to be sold to Persons outside the United States or to Persons that
are not U.S. Persons in an "offshore transaction" (as

                                     - 14 -
<PAGE>

defined in the Securities Act Rule 902(i)), subject to certain terms and
conditions and (iii) hedging transactions involving the Securities may not be
conducted unless in compliance with the Securities Act;

                  (c) such Purchaser acknowledges that for a period of one year
following the Final Closing Date (the "Restricted Period"), such Purchaser shall
not (i) engage in any activity undertaken for the purpose of, or that could
reasonably be expected to have the effect of, conditioning the market in the
United States for the Securities or (ii) unless such Securities are registered
under the Securities Act or an exemption from the registration requirements of
the Securities Act is available, offer, sell or transfer any of the Securities
in the United States or to, or for the account or benefit of, a U.S. Person.
Such Purchaser understands that the Securities and any interest therein are only
transferable on the books and records of the transfer agent and registrar of the
Company. Such Purchaser further understands that such transfer agent and
registrar will not register any transfer of the Securities which the Company
believes may violate the restrictions set forth in this paragraph (c), and that
the Company may place stop transfer orders with its transfer agent with respect
to certificates representing Securities. The Company may require a certification
satisfactory to it as a condition to such registration and transfer;

                  (d) the Purchaser did not receive any offer to purchase Units
in the United States, no directed selling efforts were made to such Purchaser in
the United States in contravention of the requirements of Regulation S and, at
the time of both the offer and sale of the Units to such Purchaser, such
Purchaser was outside the United States;

                  (e) to the best knowledge of the Purchaser, each distributor
(as the term is defined in Regulation S) participating in the Regulation S
Offering, if any, has agreed that all offers and sales of the Units prior to the
expiration of a period of one year commencing on the Final Closing Date shall
only be made in compliance with the safe harbor provisions contained in
Regulation S and the Restricted Period, or pursuant to registration of the
Securities under the Securities Act or pursuant to an applicable exemption from
registration under the Securities Act;

                  (f) such Purchaser agrees that for a two year period following
the Final Closing Date (the "Legend Period") the Notes shall bear the legend set
forth below and the Conversion Securities, Equity Warrants, Alternative Equity
Warrants, Common Stock and Unit Underlying Common Stock shall bear a similar
legend:

         "THE TERMS OF THIS NOTE ARE SUBJECT TO THE TERMS OF A UNIT PURCHASE
         AGREEMENT, A COPY OF WHICH IS AVAILABLE FROM HYBRIDON, INC. (THE
         "COMPANY"). THE SECURITIES REPRESENTED BY THIS NOTE HAVE NOT BEEN
         REGISTERED UNDER THE UNITED STATES SECURITIES ACT OF 1933, AS AMENDED
         (THE "SECURITIES ACT"), OR ANY

                                     - 15 -
<PAGE>

         APPLICABLE STATE SECURITIES LAWS, AND MAY NOT BE SOLD, OFFERED FOR
         SALE, PLEDGED OR HYPOTHECATED OR OTHERWISE TRANSFERRED IN THE ABSENCE
         OF A REGISTRATION STATEMENT IN EFFECT WITH RESPECT TO THE SECURITIES
         UNDER THE SECURITIES ACT OR AN EXEMPTION FROM THE SECURITIES ACT. ANY
         SUCH TRANSFER MAY ALSO BE SUBJECT TO COMPLIANCE WITH APPLICABLE STATE
         SECURITIES LAWS AND THE LAWS OF OTHER APPLICABLE JURISDICTIONS.

         THIS NOTE MAY NOT BE OFFERED OR SOLD IN THE UNITED STATES OR TO A U.S.
         PERSON OR FOR THE ACCOUNT OR BENEFIT OF A U.S. PERSON PRIOR TO THE
         EXPIRATION OF THE RESTRICTED PERIOD (AS DEFINED IN THE PURCHASE
         AGREEMENT), AND NO TRANSFER OR EXCHANGE OF THIS NOTE MAY BE MADE UNTIL
         AFTER THE LATER OF THE DATE OF EXPIRATION OF THE RESTRICTED PERIOD AND
         THE DATE ON WHICH THE REQUIRED CERTIFICATION RELATING TO SUCH INTEREST
         HAS BEEN PROVIDED IN ACCORDANCE WITH THE TERMS OF THE PURCHASE
         AGREEMENT. HEDGING TRANSACTIONS INVOLVING THE NOTES MAY NOT BE
         CONDUCTED UNLESS IN COMPLIANCE WITH THE SECURITIES ACT.";

                  (g) each Purchaser requesting removal of any legend shall
provide to the Company a written representation that, during the Restricted
Period, neither Units nor Securities were sold or arranged to be sold in the
United States or to a U.S. Person and that neither the Units nor any Securities
will be used to cover a short sale or other borrowing of any securities of the
Company in the United States made during the Restricted Period;

                  (h) such Purchaser is not purchasing the Units nor any
Securities as part of any plan or scheme to evade the registration requirements
of the Securities Act; and

                  (i) such Purchaser understands that, when exercising an
Alternative Equity Warrant or Equity Warrant, the Purchaser will be required to
give (a) written certification that it is not a U.S. Person and the Alternative
Equity Warrant or Equity Warrant is not being exercised on behalf of a U.S.
Person, or (b) a written opinion of counsel to the effect that the Alternative
Equity Warrant or Equity Warrant and the securities delivered upon exercise
thereof have been registered under the Securities Act or are exempt from
registration thereunder.

                  7.2. FOREIGN STATUS. The Purchaser hereby represents that (a)
such Purchaser (1) is not a citizen or resident of the United States, a
corporation or partnership organized under the laws of the United States or any
state thereof or a trust or estate whose income is includable in gross income
for United States Federal income tax purposes regardless of its source and (2)
has accurately completed the Form W-8 attached hereto as EXHIBIT H, or (b) such
Purchaser will

                                     - 16 -
<PAGE>

promptly provide the Company with an accurately completed Form W-9 or
substitute Form W-9 providing such Purchaser's U.S. taxpayer identification
number. The Purchaser hereby consents to the withholding from payments
otherwise due and payable by the Company of amounts required to be withheld
under applicable tax law.

         8. REPRESENTATION. Warranties and Covenants of the Company. Except
as set forth on the Schedule of Exceptions attached hereto as EXHIBIT I,
the Company hereby represents, warrants and covenants to each Purchaser that:

                  8.1. ORGANIZATION, GOOD STANDING AND QUALIFICATION. The
Company is a corporation duly organized, validly existing and in good standing
under the laws of the State of Delaware and has the corporate power and
authority to conduct its business as described in the Term Sheet. The Company is
duly qualified to do business as a foreign corporation and is in good standing
in Massachusetts and in each jurisdiction in which the nature of the business
conducted, or as proposed to be conducted in the Term Sheet, by it or the
properties owned, leased or operated by it, makes such qualification or
licensing necessary and where the failure to be so qualified or licensed would
have a material adverse effect upon the business, operations or financial
condition of the Company.

                  8.2. CAPITALIZATION AND VOTING RIGHTS. The authorized, issued
and outstanding capital stock of the Company, as of the date of the Term Sheet,
is as set forth in the Term Sheet under the heading "Equity Capitalization and
Indebtedness"; all issued and outstanding shares of capital stock of the Company
are validly issued, fully paid and nonassessable. Except as set forth in the
Term Sheet, as of the date of the Term Sheet, there are no outstanding options,
warrants, agreements, convertible securities, preemptive rights or other rights
to subscribe for or to purchase any shares of capital stock of the Company.
Except as set forth in the Term Sheet, in this Agreement and as otherwise
required by law, there are no restrictions upon the voting or transfer of the
Transfer Restricted Securities (as defined in Section 12.1) pursuant to the
Company's Certificate of Incorporation, as amended (the "Certificate of
Incorporation"), Bylaws or other governing documents or any agreement or other
instruments to which the Company is a party or by which the Company is bound.

                  8.3. AUTHORIZATION, ENFORCEABILITY. The Company has the
corporate power and authority to enter into this Agreement and to consummate the
transactions contemplated hereby. All corporate action on the part of the
Company, its directors and stockholders necessary for the execution, delivery
and performance of this Agreement by the Company, the sale, issuance and
delivery of the Units contemplated hereby and the performance of the Company's
obligations hereunder has been taken. This Agreement has been duly executed and
delivered by the Company and constitutes a legal, valid and binding obligation
of the Company, enforceable against the Company in accordance with its terms,
subject to laws of general application relating

                                     - 17 -
<PAGE>

to bankruptcy, insolvency and the relief of debtors and rules of law
governing specific performance, injunctive relief or other equitable remedies,
and to limitations of public policy. Upon the issuance and delivery of the
Conversion Securities and Registrable Securities, as contemplated by this
Agreement, such securities will be duly and validly authorized and issued, fully
paid and nonassessable. The issuance and sale of the securities contemplated
hereby will not give rise to any preemptive rights or rights of first refusal on
behalf of any person.

                  8.4. NO CONFLICT; GOVERNMENTAL CONSENTS.

                  (a) The execution and delivery by the Company of this
Agreement and the consummation by the Company of the transactions contemplated
hereby will not result in the violation of any law, statute, rule, regulation,
order, writ, injunction, judgment or decree of any court or governmental
authority to or by which the Company is bound, or of any provision of the
Certificate of Incorporation or By-laws of the Company, and will not conflict
with, or result in a material breach or violation of, any of the terms or
provisions of, or constitute (with due notice or lapse of time or both) a
material default under, any material lease, loan agreement, mortgage, security
agreement, note, trust indenture or other agreement or instrument to which the
Company is a party or by which it is bound or to which any of its properties or
assets is subject nor result in the creation or imposition of any lien upon any
of the properties or assets of the Company other than in favor of the Secured
Party.

                  (b) No consent, approval, authorization or other order of any
governmental authority or other third-party under any material agreement to
which the Company is a party is required to be obtained by the Company in
connection with the authorization, execution and delivery of this Agreement or
with the authorization, issuance and sale of the Units, except such as have
already been obtained, and such filings as may be required to be made with the
Securities and Exchange Commission and with any state or foreign "blue sky" or
securities regulatory authority.

                  8.5. GOVERNMENTAL AUTHORIZATIONS. Except as set forth in the
Term Sheet, the Company has, on the date hereof and on the relevant Closing
Date, all material licenses, permits and other governmental authorizations
currently required for the conduct of its business or ownership of properties
and is in all material respects complying therewith.

                  8.6. LITIGATION. Except as set forth in the Term Sheet, on the
date hereof and on the relevant Closing Date, the Company knows of no pending
or, to the knowledge of the Company, threatened legal or governmental
proceedings against the Company which could materially adversely affect the
business, financial condition or operations of the Company (other than
proceedings with respect to overdue trade payables not exceeding $8 million,
which payables were incurred in the ordinary course of business).

                                     - 18 -
<PAGE>

                  8.7. ACCURACY OF REPORTS. All reports required to be filed by
the Company since and including the most recent filing of the Company's Annual
Report on Form 10-K, to and including the relevant Closing Date, have been duly
filed with the Securities and Exchange Commission, complied at the time of
filing in all material respects with the requirements of their respective forms
and were complete and correct in all material respects as of the dates at which
the information was furnished, and contained (as of such dates) no untrue
statement of a material fact or omitted to state a material fact necessary in
order to make the statements contained therein, in light of the circumstances
under which they were made, not misleading.

                  8.8. INVESTMENT COMPANY. The Company is not an "investment
company" within the meaning of such term under the Investment Company Act of
1940, as amended, and the rules and regulations of the Securities and Exchange
Commission thereunder.

                  8.9. PAYMENT OF NOTES. The Company shall pay the principal of
and interest on the Notes on the dates and in the manner provided in the Notes
and this Agreement. To the extent lawful, the Company shall pay interest
(including post-petition interest in any proceeding under any Bankruptcy Law) on
(i) overdue principal of the Notes at the rate borne by the Notes and (ii)
overdue installments of interest at the same rate.

                  8.10. STAY, EXTENSION AND USURY LAWS. The Company covenants
(to the extent that it may lawfully do so) that it will not at any time insist
upon, plead, or in any manner whatsoever claim or take the benefit or advantage
of, any stay, extension or usury law wherever enacted, now or at any time
hereinafter in force, which may affect the covenants or the performance of the
transactions contemplated by this Agreement; and the Company (to the extent it
may lawfully do so) hereby expressly waives all benefit or advantage of any such
law.

                  8.11. INSURANCE. The Company will at all times if and so long
as Notes are outstanding maintain valid policies of worker's compensation and
such other insurance with respect to its properties and business of the kinds
and in amounts not less than is customarily maintained by corporations engaged
in the same or similar business and similarly situated.

                  8.12. CORPORATE EXISTENCE; MAINTENANCE OF PROPERTIES. The
Company will at all times, so long as Notes are outstanding, cause to be done
all things necessary to maintain, preserve and renew its existence and will
preserve and keep in force and effect, all licenses, permits and authorizations
necessary to the conduct of its business, the loss of which would have a
material adverse effect on the business and operations of the Company. The
Company will also maintain and keep its properties in good repair, working order
and condition, ordinary wear and tear excepted, if and so long as Notes are
outstanding.

                                     - 19 -
<PAGE>

                  8.13. TAXES AND LIENS. If and so long as Notes are
outstanding, the Company will duly pay and discharge when payable, all taxes,
assessments and governmental charges imposed upon or against the Company or its
properties, or any part thereof or upon the income or profits therefrom, in each
case before the same become delinquent and before penalties accrue thereon, as
well as all claims for labor, materials or supplies which if unpaid might by law
become a lien upon any of its property, unless and to the extent that the same
are being contested in good faith and by appropriate proceedings and the Company
has set aside on its books adequate reserves with respect thereto.

                  8.14. MERGER; SALE OF ASSETS. If and so long as Notes are
outstanding, the Company shall not consolidate with or merge into, or sell,
lease, convey or otherwise dispose of all or substantially all of its assets to,
any Person in a single transaction or series of related transactions, without
the consent of the Secured Party, unless:

                  (a) the Company is the continuing corporation or the Person
formed by or surviving any such consolidation or merger (if other than the
Company), or to which such sale, lease, conveyance or other disposition of
assets shall have been made, is organized and existing under the laws of the
United States, any state thereof or the District of Columbia and such Person (if
other than the Company) expressly assumes by supplemental agreement executed and
delivered to the Secured Party, all the obligations of the Company under the
Notes and, in respect of the Notes, this Agreement;

                  (b) immediately before and immediately after giving effect to
the transaction no Event of Default (as such term is defined in the Notes), and
no event which, after notice or lapse of time, or both, would become an Event of
Default (a "Default"), shall have occurred and be continuing; and

                  (c) immediately after giving effect to such transaction, the
Notes and this Agreement (as supplemented by any such supplemental agreement)
will be valid and enforceable obligations of the Company or such successor.

                  8.15. TERM SHEET DISCLOSURE. No information set forth in the
Term Sheet contains, as of the date hereof or the relevant Closing Date, any
untrue statement of a material fact or omits to state a material fact necessary
in order to make the statements contained therein, in light of the circumstances
under which they were made, not misleading.

                  8.16. RESERVATION OF SHARES; TRANSFER TAXES, ETC. The Company
shall at all times reserve and keep available, out of its authorized and
unissued shares of Conversion Securities, solely for the purpose of effecting
the conversion of the Notes and the exercise of the Placement and Advisory
Warrants, such number of shares of its Conversion Securities free of

                                     - 20 -
<PAGE>

preemptive rights as shall be sufficient to effect the conversion of all
Notes from time to time outstanding and the exercise of all Placement
and Advisory Warrants from time to time outstanding. The Company shall use
its best efforts from time to time, in accordance with the laws of the State
of Delaware to increase the authorized number of shares of Conversion Securities
if at any time the number of shares of authorized, unissued and unreserved
shares of Conversion Securities shall not be sufficient to permit the conversion
of all the then-outstanding Notes and the exercise of all the then-outstanding
Placement and Advisory Warrants. The Company shall not issue any Conversion
Securities other than to effect the conversion of the Notes or accrued interest
thereon, Conversion Securities sold in lieu of Notes in the Offering and
Conversion Securities issuable upon exercise of Placement and Advisory Warrants.

         The Company shall pay any and all issue or other taxes (but in no event
income taxes) that may be payable in respect of any issue or delivery of shares
of Conversion Securities on conversion of the Notes or the exercise of the
Placement and Advisory Warrants. The Company shall not, however, be required to
pay any tax which may be payable in respect of any transfer involved in the
issue or delivery of Conversion Securities (or other securities or assets) in a
name other than that in which the Notes so converted, or the Placement and
Advisory Warrants so exercised, were registered, and no such issue or delivery
shall be made unless and until the person requesting such issue has paid to the
Company the amount of such tax or has established, to the satisfaction of the
Company, that such tax has been paid.

                  8.17. LISTING. If the Company's Common Stock becomes traded on
the Nasdaq National Market (the "Nasdaq"), the Company shall take such action as
is necessary in accordance with the rules of the Nasdaq to enable the
Registrable Securities (as defined in Section 12.1) to trade on the Nasdaq.

                  8.18. PROPRIETARY RIGHTS. Except as has been or will be
reflected in the Term Sheet prior to the relevant Closing, the Company owns or
possesses adequate and enforceable rights to use all patents, patent
applications, trademarks, service marks, trade names, corporate names,
copyrights, trade secrets, processes, mask works, licenses, inventions,
formulations, technology and know-how and other intangible property used or
proposed to be used in the conduct of its business as described in, or
contemplated by, the Term Sheet (the "Proprietary Rights"). Except as has been
or will be reflected in the Term Sheet prior to the relevant Closing, the
Company or the entities from whom the Company has acquired rights has taken all
necessary action to protect all of the Company's Proprietary Rights. Except as
set forth in the Term Sheet, as of the relevant Closing: the Company has not
received any notice of, and there are not any facts known to the Company that
indicate the existence of (i) any infringement or misappropriation by any third
party of any of the Proprietary Rights or (ii) any claim by a third party
contesting the validity of any of the Proprietary Rights; the Company has not
received any notice of any infringement, misappropriation or violation by the
Company or any of its

                                     - 21 -
<PAGE>

employees of any Proprietary Rights of third parties, and, to the best of the
Company's knowledge, neither the Company nor any of its employees has
infringed, misappropriated or otherwise violated any Proprietary Rights
of any third parties; and, to the best of the Company's knowledge, no
infringement, illicit copying, misappropriation or violation of any intellectual
property rights of any third party by the Company has occurred or will occur
with respect to any products currently being sold by the Company or with respect
to any products currently under development by the Company or with respect to
the conduct of the Company's business as currently contemplated. Except as
described in the Term Sheet, as of the relevant Closing, the Company is not
aware that any of its employees are obligated under any contract (including
licenses, covenants or commitments of any nature) or other agreement, or subject
to any judgment, decree or order of any court or administrative agency, which
would interfere with the use of the employee's best efforts to promote the
interests of the Company or that would conflict with the Company's business as
currently conducted or as proposed to be conducted. To the best of the Company's
knowledge, as of the relevant Closing, neither the execution nor delivery of
this Agreement, nor the carrying on of the Company's business by the employees
of the Company, nor the conduct of the Company's business, as currently
conducted or as proposed to be conducted, will conflict with, or result in, a
breach of the terms, conditions or provisions of, or constitute a default under,
any contract, covenant or instrument under which any such employee is now
obligated. In addition, as of each Closing, all employees are required to assign
intellectual property rights to the Company.

         9.       SUBORDINATION.

                  9.1. AGREEMENT TO SUBORDINATE. The Company covenants and
agrees, and each Purchaser and any subsequent holder of a Note (each, a
"Holder"), by such Holder's acceptance of a Note, likewise covenants and agrees,
that, to the extent and in the manner hereinafter set forth in this Article 9,
the indebtedness represented by the Notes and the payment of the principal of
and interest on each and all of the Notes and the security interest given as
security for the Notes are hereby expressly made subordinate and subject in
right of payment to the prior payment in full of all Senior Indebtedness.

         No provision of this Article 9 shall prevent the occurrence of any
default or event of default hereunder.

                  9.2. PAYMENT OVER OF PROCEEDS UPON DISSOLUTION, ETC. In the
event of (a) any insolvency or bankruptcy case or proceeding, or any
receivership, liquidation, reorganization or other similar case or proceeding in
connection therewith, relative to the Company or to its creditors, as such, or
to its assets, or (b) any liquidation, dissolution or other winding-up of the
Company, whether voluntary or involuntary and whether or not involving
insolvency or bankruptcy, (c) any assignment for the benefit of creditors or any
other marshalling of assets and

                                     - 22 -
<PAGE>

liabilities of the Company, then and in any such event the holders of
Senior Indebtedness shall be entitled to receive payment in full of all
amounts due or to become due on or with respect to all Senior Indebtedness,
or provision shall be made for such payment in money or money's worth, before
the Holders are entitled to receive any payment on account of principal of, or
interest on, the Notes, and to that end the holders of Senior Indebtedness shall
be entitled to receive, for application to the payment thereof, any payment or
distribution of any kind or character, whether in cash, property or securities,
which may be payable or deliverable with respect to the Notes in any such case,
proceeding, liquidation, dissolution or other winding up or event.

         In the event that, notwithstanding the foregoing provisions of this
Section 9.2, any Holder shall have received any payment or distribution of
assets of the Company of any kind or character, whether in cash, property or
securities, before all Senior Indebtedness is paid in full or payment thereof
provided for, then and in such event such payment or distribution shall be held
in trust by such recipient and shall be paid over or delivered forthwith to the
trustee in bankruptcy, receiver, liquidating trustee, custodian, assignee, agent
or other Person making payment or distribution of assets of the Company for
application in the form received to the payment of all Senior Indebtedness
remaining unpaid, to the extent necessary to pay all Senior Indebtedness in
full, after giving effect to any concurrent payment or distribution to or for
the holders of Senior Indebtedness.

         The consolidation of the Company with, or the merger of the Company
into, another Person or the liquidation or dissolution of the Company following
the conveyance or transfer of its properties and assets substantially as an
entirety to another Person upon the terms and conditions set forth in Section
8.14 shall not be deemed a dissolution, winding-up, liquidation, reorganization,
assignment for the benefit of creditors or marshalling of assets and liabilities
of the Company for the purposes of this Section 9.2 if the Person formed by such
consolidation or into which the Company is merged or the Person which acquires
by conveyance or transfer such properties and assets substantially as an
entirety, as the case may be, shall, as a part of such consolidation, merger,
conveyance or transfer, comply with the conditions set forth in Section 8.14.

                  9.3. PRIOR PAYMENT TO SENIOR INDEBTEDNESS UPON ACCELERATION OF
NOTES. In the event that any Notes are declared due and payable before their
stated maturity, then in such event the holders of Senior Indebtedness
outstanding at the time such Notes so become due and payable shall be entitled
to receive payment in full of all amounts due or to become due on or with
respect to such Senior Indebtedness, or provision shall be made for such payment
in money or money's worth, before the Holders are entitled to receive any
payment by the Company on account of the principal of or interest on the Notes
or on account of the purchase or other acquisition of Notes. The Holders shall
provide notice to the holders of the Senior Indebtedness

                                     - 23 -
<PAGE>

of the occurrence of any default or Event of Default under the Notes at the
time that such notice is provided to the Company.

         In the event that, notwithstanding the foregoing, the Company shall
make any payment to any Holder prohibited by the foregoing provision of this
Section 9.3, then and in such event such payment shall be held in trust by such
recipient and shall be paid over and delivered forthwith to the Company in the
form received.

         The provisions of this Section 9.3 shall not apply to any payment with
respect to which Section 9.2 would be applicable.

                  9.4. NO PAYMENT WHEN SENIOR INDEBTEDNESS IN DEFAULT.

                  (a) In the event and during the continuation of any default in
the payment of principal of or interest on any Senior Indebtedness beyond any
applicable grace period with respect thereto, or in the event that any event of
default with respect to any Senior Indebtedness shall have occurred and be
continuing (or would arise by reason of a payment required hereunder by the
Company with respect to the principal of or interest on the Notes) permitting
the holders of such Senior Indebtedness (or a trustee on behalf of the holders
thereof) to declare such Senior Indebtedness due and payable prior to the date
on which it would otherwise have become due and payable, unless and until such
event of default shall have been cured or waived or shall have ceased to exist
or the Company shall have received written notice from an authorized
representative of the Senior Indebtedness with respect to which such event of
default relates approving payment on the Notes, then no payment shall be made by
the Company with respect to the principal of or interest on the Notes or to
acquire any of the Notes; provided that no such default will prevent any payment
on, or with respect to, the Notes for more than 120 days after written notice of
such default or Event of Default has been given to the Secured Party unless the
maturity of such Senior Indebtedness has been accelerated. Not more than one
such 120 day delay may be made in any consecutive 360 day period with respect to
a covenant default, irrespective of the number of defaults with respect to
Senior Indebtedness during such period.

         In the event that, notwithstanding the foregoing, the Company shall
make any payment to any Holder prohibited by the foregoing provision of this
Section 9.4, then and in such event such payment shall be held in trust by such
recipient and shall be paid over and delivered forthwith to the Company in the
form received.

         The provisions of this Section 9.4 shall not apply to any payment with
respect to which Section 9.2 would be applicable.

                                     - 24 -
<PAGE>

                  9.5. PAYMENT PERMITTED IF NO DEFAULT. Nothing contained in
this Article 9 or elsewhere in this Agreement or in any of the Notes shall
prevent the Company, at any time except when any of the conditions described in
Section 9.2, 9.3 or 9.4 exist, from making payments at any time of principal of
or interest on the Notes.

                  9.6. SUBROGATION TO RIGHTS OF HOLDERS OF SENIOR INDEBTEDNESS.
Subject to the payment in full of all Senior Indebtedness, Holders shall be
subrogated to the extent of the payments or distributions made to the holders of
such Senior Indebtedness pursuant to the provisions of this Article 9 (equally
and ratably with the holders of all indebtedness of the Company which is not
Senior Indebtedness and which is entitled to like rights of subrogation) to the
rights of the holders of such Senior Indebtedness to receive payments and
distributions of cash, property and securities applicable to the Senior
Indebtedness until the principal of and interest on the Notes shall be paid in
full. For purposes of such subrogation, no payments or distributions to the
holders of Senior Indebtedness of any cash, property or securities to which
Holders would be entitled except for the provisions of this Article 9, and no
payments over pursuant to the provisions of this Article 9 to the holders of
Senior Indebtedness by Holders, shall, as among the Company, its creditors other
than holders of Senior Indebtedness and Holders be deemed to be a payment or
distribution by the Company to or on account of Senior Indebtedness.

                  9.7. PROVISIONS SOLELY TO DEFINE RELATIVE RIGHTS. The
provisions of this Article 9 are and are intended solely for the purpose of
defining the relative rights of the Holders on the one hand and the holders of
Senior Indebtedness on the other hand. Nothing contained in this Article 9 or
elsewhere in this Agreement or in the Notes is intended to or shall: (a) impair,
as among the Company, its creditors other than holders of Senior Indebtedness
and the Holders, the obligation of the Company, its creditors other than holders
of Senior Indebtedness and the Holders, the obligation of the Company, which is
absolute and unconditional (and which, subject to the rights under this Article
9 of the holders of Senior indebtedness, is intended to rank equally with all
other general obligations of the Company), to pay to the Holders the principal
of and interest on the Notes as and when the same shall become due and payable
in accordance with their terms; or (b) affect the relative rights against the
Company of the Holders and creditors of the Company other than the holders of
Senior Indebtedness; or (c) prevent the Secured Party or any Holder from
exercising all remedies otherwise permitted by applicable law upon default under
this Agreement, subject to the rights, if any, under this Article 9 of the
holders of Senior Indebtedness to receive cash, property and securities
otherwise payable or deliverable to the Secured Party or such Holder.

                  9.8. SECURED PARTY TO EFFECTUATE SUBORDINATION. Each Holder of
a Note by acceptance thereof authorizes and directs the Secured Party on such
Holder's behalf to take such

                                     - 25 -
<PAGE>

action as may be necessary or appropriate to effectuate the subordination
provided in this Article 9 and appoints the Secured Party as such Holder's
attorney-in-fact for any and all such purposes.

                  9.9. NO WAIVER OF SUBORDINATION PROVISIONS. No right of any
present or future holder of any Senior Indebtedness to enforce subordination as
herein provided shall at any time in any way be prejudiced or impaired by any
act or failure to act by the Company or by any act or failure to act, in good
faith, by any such holder, or by any non-compliance by the Company with the
terms, provisions and covenants of this Agreement, regardless of any knowledge
thereof any such holder may have or be otherwise charged with. Without in any
way limiting the generality of the foregoing paragraph, the holders of Senior
Indebtedness may, at any time and from time to time, without the consent of or
notice to Holders, without incurring responsibility to Holders and without
impairing or releasing the subordination provided in this Article 9 or the
obligations hereunder of Holders to the holders of Senior Indebtedness, do any
one or more of the following: (i) change the manner, place or terms of payment
or extend the time of payment of, or renew or alter, Senior Indebtedness, or
otherwise amend or supplement in any manner Senior Indebtedness or any
instrument evidencing the same or any agreement under which Senior Indebtedness
is outstanding; (ii) sell, exchange, release or otherwise deal with any property
pledged, mortgaged or otherwise securing Senior Indebtedness; (iii) release any
Person liable in any manner for the collection of Senior Indebtedness; and (iv)
exercise or refrain from exercising any rights against the Company and any other
Person.

                  9.10. RELIANCE ON JUDICIAL ORDER OR CERTIFICATE OF LIQUIDATING
AGENT. Upon any payment or distribution of assets of the Company referred to in
this Article 9, the Secured Party and the Holders shall be entitled to rely upon
any order or decree entered by any court of competent jurisdiction in which such
insolvency, bankruptcy, receivership, liquidation, reorganization, dissolution,
winding-up or similar case or proceeding is pending, or a certificate of the
trustee in bankruptcy, receiver, liquidating trustee, custodian, assignee for
the benefit of creditors, agent or other Person making such payment or
distribution, delivered to the Secured Party or to the Holders, for the purpose
of ascertaining the Persons entitled to participate in such payment or
distribution, the holders of the Senior Indebtedness and other indebtedness of
the Company, the amount thereof or payable thereon, the amount or amounts paid
or distributed thereon and all other facts pertinent thereto or to this Article
9.

                  9.11. CERTAIN CONVERSIONS DEEMED PAYMENT. For the purposes of
this Article 9 only, (a) the issuance and delivery of Junior Securities upon
conversion of Notes in accordance with Section 3 of the Notes or in lieu of cash
interest in accordance with Section 1 of the Notes shall not be deemed to
constitute a payment or distribution on account of the principal, of or interest
on Notes or on account of the purchase or other acquisition of Notes and (b) the
payment, issuance or delivery of cash, property or securities (other than Junior
Securities) upon conversion of a Note shall be deemed to constitute payment on
account of the principal of such

                                     - 26 -
<PAGE>

Note. Nothing contained in this Article 9 or elsewhere in this Agreement or in
the Notes is intended to or shall impair, as among the Company, its creditors
other than holders of Senior Indebtedness and the Holders, the right, which is
absolute and unconditional, of a Holder to convert any Note in accordance with
Section 3 of the Notes.

                  9.12. ALTERNATIVE OFFERING. This Article 9 shall be
inapplicable in the case of the Alternative Offering.

         10.      SECURED PARTY'S RIGHTS AND REMEDIES

                  10.1. RIGHTS AND REMEDIES. Upon the occurrence and during the
continuance of an Event of Default (as defined in the Note), the Secured Party
may, in addition to the remedies pursuant to Section 6 of the Notes, at its
election, without notice of its election and without demand, take any action
permitted by law and not in contravention or inconsistent with Article 9. This
Section 10.1 shall be inapplicable in the case of the Alternative Offering.

         11.      CERTAIN DEFINITIONS.  For the purposes of this Agreement the
following terms have the respective meanings set forth below:

                  11.1. "BUSINESS DAY" means a Monday through Friday on which
banks are generally open for business in New York, Massachusetts and California.
in Section 1.1.

                  11.2. "CERTIFICATE OF DESIGNATION" shall have the meaning
ascribed to such term

                  11.3. "COMMON STOCK" means the Company's common stock.

Section 1.1.

                  11.4. "CONVERSION SECURITIES" shall have the meaning ascribed
to such term in

                  11.5. "EXCHANGE OFFER" means the Company's offer to the
holders of its 9 Convertible Subordinated Notes due 2004 to exchange such notes
and all accrued interest thereon for preferred stock and warrants of the
Company.

                  11.6. "JUNIOR SECURITIES" means (a) shares of any and all
classes of capital stock of the Company and (b) securities of the Company which
are subordinated in right of payment to Senior Indebtedness at the time of
issuance or delivery of such securities to substantially the same extent as, or
to a greater extent than, the Notes are so subordinated as provided in Article
9.

                                     - 27 -
<PAGE>

                  11.7. "LIEN" means any mortgage, lien, deed of trust, charge,
pledge, security interest or other encumbrance.

                  11.8. [Reserved]

                  11.9. "PERSON" means any individual, sole proprietorship,
partnership, limited liability company, joint venture, trust, unincorporated
organization, association, corporation, institution, public benefit corporation,
firm, joint stock company, estate, entity or governmental agency.

                  11.10. "PLACEMENT AGENT" shall have the meaning ascribed to
such term in Section 1.3 and "Placement Agents" shall mean the placement agents
for the Regulation D Offering and the Regulation S Offering, referred to in
Sections 1.2 and 1.3, respectively.

                  11.11. "PLACEMENT AND ADVISORY WARRANTS" shall mean the
placement and advisory warrants to be granted to the Placement Agents and/or
their respective designees pursuant to separate placement agency agreements and
financial advisory agreements between the Company and the Placement Agents.

                  11.12. "REGULATION D" means Regulation D promulgated under the
Securities Act.

                  11.13. "REGULATION D OFFERING" shall have the meaning ascribed
to such term in

                  11.14. "REGULATION S" means Regulation S promulgated under the
Securities Act.

                  11.15. "REGULATION S OFFERING" shall have the meaning ascribed
to such term in Section 1.3.

                  11.16. "SECURED PARTY" shall have the meaning ascribed to such
term in Section 5.1.

                  11.17. "SECURITIES ACT" means, as of any given time, the
Securities Act of 1933, as amended, or any similar federal law then in force.

                  11.18. "SECURITIES AND EXCHANGE COMMISSION" includes any
governmental body or agency succeeding to the functions thereof.

                  11.19. "SENIOR INDEBTEDNESS" means the principal of (and
premium, if any) and accrued interest on (including all interest accruing
subsequent to the commencement of any

                                     - 28 -
<PAGE>

bankruptcy or similar proceeding, whether or not a claim for post-petition
interest is allowable as a claim in any such proceeding) (a) obligations
of the Company under the Loan and Security Agreement, dated December 31,
1996, between Silicon Valley Bank and the Company, including any related
notes, guarantees, collateral documents, instruments and agreements executed in
connection therewith, and in each case as amended, modified, renewed, replaced,
restated, supplemented, refunded or refinanced from time to time (provided that
the principal amount does not exceed $7,500,000 and the maturity date is not
advanced), (b) obligations of the Company, whether outstanding on the date of
this Agreement or hereafter created, incurred or assumed, as lessee under leases
required to be capitalized on the balance sheet of the lessee under generally
accepted accounting principles and leases of property or assets made as part of
any sale and leaseback transaction to which the Company is a party, (c) all
reimbursement obligations and other liabilities (contingent or otherwise) with
respect to letters of credit, bank guarantees or bankers' acceptances, and (d)
any amendments, renewals, extensions, modifications and refundings of any such
indebtedness or obligation under clauses (a) (provided that the principal amount
does not exceed $7,500,000 and the maturity date is not advanced), (b) or (c),
above.

                  11.20. "SUBSIDIARY" means any person, corporation, firm or
entity at least the majority of the equity securities (or equivalent interest)
of which are, at the time as of which any determination is being made, owned of
record or beneficially by the Company, directly or indirectly, through any
Subsidiary or otherwise.

                  11.21. "TERM SHEET" shall have the meaning ascribed to such
term in Section 6.5.

                  11.22. "TRADING DAY" means (i) if the applicable security is
listed or admitted for trading on a national security exchange, a day on which
such exchange is open for business, (ii) if the applicable security is quoted on
the Nasdaq Stock Market, a day on which trades may be made thereon or (iii) if
the applicable security is not so listed, admitted for trading or quoted, any
Business Day.

                  11.23. "UNIT OFFERING", "OFFERING" and "UNITS" shall have the
meaning ascribed to such terms in the first paragraph of this Agreement.

                  11.24. "UNIT-UNDERLYING COMMON STOCK" shall mean the Common
Stock issuable upon conversion of any Conversion Securities, issuable upon
conversion of, or in lieu of, Notes or upon exercise of any Equity Warrants or
Alternative Equity Warrants, in each case including any such Conversion
Securities or Equity Warrants issuable upon exercise of any Placement and
Advisory Warrants or upon conversion of Notes issuable upon exercise of any
Placement and Advisory Warrants.

                  11.25. (1) "U.S. PERSON" means:

                                     - 29 -
<PAGE>

                   (i)  Any natural person resident in the United States;

                  (ii)  Any partnership or corporation organized or incorporated
                        under the laws of the United States;

                 (iii)  Any estate of which any executor or administrator is a
                        U.S. Person;

                  (iv)  Any trust of which any trustee is a U.S. Person;

                   (v)  Any agency or branch of a foreign entity located in the
                        United States.

                  (vi)  Any non-discretionary account or similar account (other
                        than an estate or trust) held by a dealer or other
                        fiduciary for the benefit or account of a U.S. Person;

                 (vii)  Any discretionary account or similar account (other
                        than an estate or trust) held by a dealer or other
                        fiduciary organized, incorporated, or (if an
                        individual) resident in the United States; and

                (viii)  Any partnership or corporation if: (A) organized or
                        incorporated under the laws of any foreign
                        jurisdiction; and (B) formed by a U.S. Person
                        principally for the purpose of investing in
                        securities not registered under the Securities Act,
                        unless it is organized or incorporated, and owned, by
                        accredited investors (as defined in Rule 501 (a) of
                        the Securities Act) who are not natural persons,
                        estates or trusts.

                  (2)   Notwithstanding clause (1) of this Section 11.25, any
discretionary account or similar account (other than an estate or trust) held
for the benefit or account of a non-U.S. Person by a dealer or other
professional fiduciary organized, incorporated, or (if an individual) resident
in the United States shall not be deemed a "U.S. Person."

                  (3)   Notwithstanding clause (1) of this Section 11.25, any
estate of which any professional fiduciary acting as executor or administrator
is a U.S. Person shall not be deemed a U.S. Person if.

                  (i)  An executor or administrator of the estate who is not a
                       U.S. Person has sole or shared investment discretion
                       with respect to the assets of the estate; and

                 (ii)  The estate is governed by foreign law.

                                     - 30 -
<PAGE>

                  (4)  Notwithstanding clause (1) of this Section 11.25, any
trust of which any professional fiduciary acting as trustee is a U.S. Person
shall not be deemed a U.S. Person if a trustee who is not a U.S. Person has sole
or shared investment discretion with respect to the trust assets, and no
beneficiary of the trust (and no settlor if the trust is revocable) is a U.S.
Person.

                  (5) Notwithstanding clause (1) of this Section 11.25, an
employee benefit plan established and administered in accordance with the law of
a country other than the United States and customary practices and documentation
of such country shall not be deemed a U.S. Person.

                  (6) Notwithstanding clause (1) of this Section 11.25, any
agency or branch of a U.S. Person located outside the United States shall not be
deemed a "U.S. Person" if:

                  (i)      The agency or branch operates for valid business
                           reasons; and

                 (ii)      The agency or branch is engaged in the business of
                           insurance or banking and is subject to substantive
                           insurance or banking regulation, respectively, in the
                           jurisdiction where located.

                  (7) The International Monetary Fund, the International Bank
for Reconstruction and Development, the Inter-American Development Bank, the
Asian Development Bank, the African Development Bank, the United Nations, and
their agencies, affiliates and pension plans, and any other similar
international organizations, their agencies, affiliates and pension plans shall
not be deemed "U.S. Persons."

                  11.26. "UNITED STATES" means the United States of America, its
territories and possessions, any state of the United States, and the District of
Columbia.

        12. REGISTRATION RIGHTS.

                  12.1. As used in this Article 12, the following terms shall
have the following meanings:

                  (a) "AFFILIATE" shall mean, with respect to any Person (as
defined below), any other Person controlling, controlled by, or under direct or
indirect common control with, such Person (for the purposes of this definition
"control," when used with respect to any specified Person, shall mean the power
to direct the management and policies of such person, directly or indirectly,
whether through ownership of voting securities, by contract or otherwise; and
the terms "controlling" and "controlled" shall have meanings correlative to the
foregoing).

                  (b) "BUSINESS DAY" shall mean a day Monday through Friday on
which banks are generally open for business in New York.

                                     - 31 -
<PAGE>

                  (c) "HOLDERS" shall mean the Purchasers and any person holding
Registrable Securities or any person to whom the rights under Article 12 have
been transferred in accordance with Section 12.10 hereof.

                  (d) "PERSON" shall mean any person, individual, corporation,
limited liability company, partnership, trust or other non-governmental entity
or any governmental agency, court, authority or other body.

                  (e) The terms "REGISTER," "REGISTERED" and "REGISTRATION"
refer to the registration effected by preparing and filing a registration
statement in compliance with the Securities Act, and the declaration or ordering
of the effectiveness of such registration statement.

                  (f) "REGISTRABLE SECURITIES" shall mean (i) the Common Stock
included in the Alternative Equity Units and the shares of Unit-Underlying
Common Stock and (ii) any shares of Common Stock issued as (or issuable upon the
conversion of any warrant, right or other security which is issued as) a
dividend or other distribution with respect to or in replacement of the Transfer
Restricted Securities (as defined below); provided, however, that securities
shall only be treated as Registrable Securities if and only for so long as they
(A) have not been disposed of pursuant to a registration statement declared
effective by the Securities and Exchange Commission, (B) have not been sold in a
transaction exempt from the registration and prospectus delivery requirements of
the Securities Act so that all transfer restrictions and restrictive legends
with respect thereto are removed upon the consummation of such sale, (C) are
held by a Holder or a permitted transferee pursuant to Section 12.10 or (D) are
not freely tradeable under applicable federal securities laws.

                  (g) "REGISTRATION EXPENSES" shall mean all expenses incurred
by the Company in complying with Section 12.2 hereof, including, without
limitation, all registration, qualification and filing fees, printing expenses,
escrow fees, fees and expenses of counsel for the Company, blue sky fees and
expenses and the expense of any special audits incident to, or required by, any
such registration (but excluding the fees of legal counsel for any Holder).

                  (h) "REGISTRATION STATEMENT" shall have the meaning ascribed
to such term in Section 12.2.

                  (i) "REGISTRATION PERIOD" shall have the meaning ascribed to
such term in Section 12.4.

                  (j) "SELLING EXPENSES" shall mean all underwriting discounts
and selling commissions applicable to the sale of Registrable Securities and all
fees and expenses of legal counsel for any Holder.

                                     - 32 -
<PAGE>

                  (k) "TRANSFER RESTRICTED SECURITIES" means each Equity
Warrant, Alternative Equity Warrant, each Note, each share of Conversion
Securities or Common Stock, each share of Common Stock included in the
Alternative Equity Units and, if such warrants have been exercised or such
Conversion Securities have been converted, the Registrable Securities, until the
earlier of (a) the date on which such security, as applicable, has been
effectively registered under the Securities Act and disposed of pursuant to, and
in accordance with, an effective Registration Statement, (b) the date on which
such security, as applicable, is distributed to the public pursuant to Rule 144
or any other applicable exemption under the Securities Act without additional
restriction upon public resale or (c) at such time as such security, as
applicable, may be sold by a Holder under Rule 144(k).

                  12.2. The Company shall use its best efforts to file a "shelf"
registration statement on the appropriate form (the "Registration Statement")
with the Securities and Exchange Commission, by the earlier of (i) the
expiration of sixty (60) days after the Final Closing Date and (ii) the date of
the filing of any registration statement with the Securities and Exchange
Commission in connection with the securities issued in the Exchange Offer, and
shall use its best efforts to effect the registration, qualifications or
compliances (including, without limitation, the execution of any required
undertaking to file post-effective amendments, appropriate qualifications or
exemptions under applicable blue sky or other state securities laws and
appropriate compliance with applicable securities laws, requirements or
regulations) as soon as practicable thereafter. Notwithstanding the foregoing,
the Company shall not be obligated to enter into any underwriting agreement for
the sale of any of the Registrable Securities. 12.3. All Registration Expenses
incurred in connection with any registration, qualification or compliance
pursuant to Section 12.2 shall be borne by the Company. All Selling Expenses
relating to the sale of securities registered by or on behalf of Holders shall
be borne by such Holders pro rata on the basis of the number of securities so
registered; provided that if a Holder uses its own legal counsel in addition to
one counsel for all of the Holders of securities registered on behalf of the
Holders, such Holder shall bear the cost of such counsel.

                  12.4. In the case of the registration, qualification or
compliance effected by the Company pursuant to this Agreement, the Company
shall, upon reasonable request, inform each Holder as to the status of such
registration, qualification and compliance. At its expense the Company shall:

                  (a) use its best efforts to keep such registration, and any
qualification, exemption or compliance under state securities laws which the
Company determines to obtain, continuously effective until the Holders have
completed the distribution described in the registration statement relating
thereto. The period of time during which the Company is required hereunder to
keep the Registration Statement effective is referred to herein as the
"Registration

                                     - 33 -
<PAGE>

Period. "Notwithstanding the foregoing, at the Company's election, the
Company may cease to keep such registration, qualification or compliance
effective with respect to any Registrable Securities, and the registration
rights of a Holder shall expire, at such time as the Holder may sell under Rule
144(k) under the Securities Act (or other exemption from registration acceptable
to the Company) in a three-month period all Registrable Securities then held by
such Holder; and

                  (b)      advise the Holders:

                  (i)      when the Registration Statement or any amendment
                           thereto has been filed with the Securities and
                           Exchange Commission and when the Registration
                           Statement or any posteffective amendment thereto has
                           become effective;

                  (ii)     of any request by the Securities and Exchange
                           Commission for amendments or supplements to the
                           Registration Statement or the prospectus included
                           therein or for additional information;

                  (iii)    of the issuance by the Securities and Exchange
                           Commission of any stop order suspending the
                           effectiveness of the Registration Statement or the
                           initiation of any proceedings for such purpose;

                  (iv)     of the receipt by the Company of any notification
                           with respect to the suspension of the qualification
                           of the Registrable Securities included therein for
                           sale in any jurisdiction or the initiation or
                           threatening of any proceeding for such purpose; and

                  (v)      of the happening of any event that requires the
                           making of any changes in the Registration Statement
                           or the prospectus included therein so that, as of
                           such date, the statements therein are not misleading
                           and do not omit to state a material fact required to
                           be stated therein or necessary to make the statements
                           therein (in the case of the prospectus, in the light
                           of the circumstances under which they were made) not
                           misleading;

                  (vi)     make every reasonable effort to obtain the withdrawal
                           of any order suspending the effectiveness of any
                           Registration Statement at the earliest possible time;

                  (vii)    furnish to each Holder, without charge, at least one
                           copy of such Registration Statement and any
                           post-effective amendment thereto, including financial
                           statements and schedules, and, if the Holder so

                                     - 34 -
<PAGE>
                           requests in writing, all exhibits (including those
                           incorporated by reference) in the form filed with the
                           Securities and Exchange Commission;

                  (viii)   during the Registration Period, deliver to each
                           Holder, without charge, as many copies of the
                           prospectus included in such Registration Statement
                           and any amendment or supplement thereto as such
                           Holder may reasonably request; and the Company
                           consents to the use, consistent with the provisions
                           hereof, of the prospectus or any amendment or
                           supplement thereto by each of the selling Holders of
                           Registrable Securities in connection with the
                           offering and sale of the Registrable Securities
                           covered by the prospectus and any amendment or
                           supplement thereto. In addition, upon the reasonable
                           request of the Holder and subject in all cases to
                           confidentiality protections reasonably acceptable to
                           the Company, the Company will meet with a Holder or a
                           representative thereof at the Company's headquarters
                           to discuss all information relevant for disclosure in
                           the Registration Statement covering the Registrable
                           Securities, and will otherwise cooperate with any
                           Holder conducting an investigation for the purpose of
                           reducing or eliminating such Holder's exposure to
                           liability under the Securities Act, including the
                           reasonable production of information at the Company's
                           headquarters;

                    (ix)   during the Registration Period, deliver to each
                           Holder, without charge, (i) as soon as practicable
                           (but in the case of the annual report of the Company
                           to its stockholders, within 120 days after the end of
                           each fiscal year of the Company) one copy of: (A) its
                           annual report to its stockholders, if any (which
                           annual report shall contain financial statements
                           audited in accordance with generally accepted
                           accounting principles in the United States of America
                           by a firm of certified public accountants of
                           recognized standing); (B) if not included in
                           substance in its annual report to stockholders, its
                           annual report on Form 10-K (or similar form); (C)
                           each of its quarterly reports to its stockholders,
                           and, if not included in substance in its quarterly
                           reports to stockholders, its quarterly report on Form
                           10-Q (or similar form); and (D) a copy of the full
                           Registration Statement (the foregoing, in each case,
                           excluding exhibits); and (ii) upon reasonable
                           request, all exhibits excluded by the parenthetical
                           to the immediately preceding clause (D), and all
                           other information that is generally available to the
                           public;

                     (x)   prior to any public offering of Registrable
                           Securities pursuant to any Registration Statement,
                           register or qualify for offer and sale under the

                                     - 35 -
<PAGE>

                           securities or blue sky laws of such jurisdictions as
                           any such Holders reasonably request in writing,
                           provided that the Company shall not for any such
                           purpose be required to qualify generally to transact
                           business as a foreign corporation in any jurisdiction
                           where it is not so qualified or to consent to general
                           service of process in any such jurisdiction, and do
                           any and all other acts or things reasonably necessary
                           or advisable to enable the offer and sale in such
                           jurisdictions of the Registrable Securities covered
                           by such Registration Statement;

                    (xi)   cooperate with the Holders to facilitate the timely
                           preparation and delivery of certificates representing
                           Registrable Securities to be sold pursuant to any
                           Registration Statement free of any restrictive
                           legends to the extent not required at such time and
                           in such denominations and registered in such names as
                           Holders may request at least three (3) business days
                           prior to sales of Registrable Securities pursuant to
                           such Registration Statement;

                   (xii)   upon the occurrence of any event contemplated by
                           Section 12.4(b)(v) above, the Company shall promptly
                           prepare a post-effective amendment to the
                           Registration Statement or a supplement to the related
                           prospectus, or file any other required document so
                           that, as thereafter delivered to purchasers of the
                           Registrable Securities included therein, the
                           prospectus will not include any untrue statement of a
                           material fact or omit to state any material fact
                           necessary to make the statements therein, in the
                           light of the circumstances under which they were
                           made, not misleading; and

                  (xiii)   use its best efforts to comply with all applicable
                           rules and regulations of the Securities and Exchange
                           Commission, and will make generally available to the
                           Holders not later than 45 days (or 90 days if the
                           fiscal quarter is the fourth fiscal quarter) after
                           the end of its fiscal quarter in which the first
                           anniversary date of the effective date of the
                           Registration Statement occurs, an earnings statement
                           satisfying the provisions of Section 11(a) of the
                           Securities Act.

                  12.5. DELAY PERIODS, SUSPENSION OF SALES. Each Holder shall
suspend, upon request of the Company, any disposition of Registrable Securities
pursuant to the Registration Statement and prospectus contemplated by Section
12.2 during (i) any period not to exceed two 30-day periods within any one
12-month period the Company requires in connection with a primary underwritten
offering of equity securities and (ii) any period, not to exceed one 45-day
period per circumstance or development, when the Company determines in good
faith that offers and sales pursuant thereto should not be made by reason of the
presence of material undisclosed

                                     - 36 -
<PAGE>

circumstances or developments with respect to which the disclosure that would
be required in such a prospectus is premature, would have an adverse effect
on the Company or is otherwise inadvisable.

                  12.6. The Holders shall have no right to take any action to
restrain, enjoin or otherwise delay any registration pursuant to Section 12.2
hereof as a result of any controversy that may arise with respect to the
interpretation or implementation of this Agreement.

                  12.7. (a) To the extent permitted by law, the Company shall
indemnify each Holder, each underwriter of the Registrable Securities and each
person controlling such Holder within the meaning of Section 15 of the
Securities Act, with respect to which any registration, qualification or
compliance has been effected pursuant to this Agreement, against all claims,
losses, damages and liabilities (or action in respect thereof), including any of
the foregoing incurred in settlement of any litigation, commenced or threatened
(subject to Subsection 12.7(c) below), arising out of or based on any untrue
statement (or alleged untrue statement) of a material fact contained in any
registration statement, prospectus or offering circular, or any amendment or
supplement thereof, incident to any such registration, qualification or
compliance, or based on any omission (or alleged omission) to state therein a
material fact required to be stated therein or necessary to make the statements
therein not misleading, in light of the circumstances in which they were made,
and shall reimburse each Holder, each underwriter of the Registrable Securities
and each person controlling such Holder, for legal and other expenses reasonably
incurred in connection with investigating or defending any such claim, loss,
damage, liability or action as incurred; provided that the Company shall not be
liable in any such case to the extent that any untrue statement or omission or
allegation thereof is made in reliance upon and in conformity with information
furnished to the Company by or on behalf of such Holder and stated to be
specifically for use in preparation of such registration statement, prospectus
or offering circular; provided that the Company shall not be liable in any such
case where the claim, loss, damage or liability arises out of or is related to
the failure of the Holder to comply with the covenants and agreements contained
in this Agreement respecting sales of Registrable Securities, and except that
the foregoing indemnity agreement is subject to the condition that, insofar as
it relates to any such untrue statement or alleged untrue statement or omission
or alleged omission made in the preliminary prospectus but eliminated or
remedied in the amended prospectus on file with the Securities and Exchange
Commission at the time the registration statement becomes effective or in the
amended prospectus filed with the Securities and Exchange Commission pursuant to
Rule 424(b) of the Securities Act or in the prospectus subject to completion and
term sheet under Rule 434 of the Securities Act, which together meet the
requirements of Section 10(a) of the Securities Act (the "Final Prospectus"),
such indemnity agreement shall not inure to the benefit of any such Holder, any
such underwriter or any such controlling person, if a copy of the Final
Prospectus furnished by the Company to the Holder for delivery was not furnished
to the person or entity asserting the loss, liability, claim or damage at or
prior to the time such

                                     - 37 -
<PAGE>

furnishing. is required by the Securities Act and the Final Prospectus would
have cured the defect giving rise to such loss, liability, claim or damage.

                  (b) Each Holder will severally, if Registrable Securities held
by such Holder are included in the securities as to which such registration,
qualification or compliance is being effected, indemnify the Company, each of
its directors and officers, each underwriter of the Registrable Securities and
each person who controls the Company within the meaning of Section 15 of the
Securities Act, against all claims, losses, damages and liabilities (or actions
in respect thereof), including any of the foregoing incurred in settlement of
any litigation, commenced or threatened (subject to Subsection 12.7(c) below),
arising out of or based on any untrue statement (or alleged untrue statement) of
a material fact contained in any registration statement, prospectus or offering
circular, or any amendment or supplement thereof, incident to any such
registration, qualification or compliance, or based on any omission (or alleged
omission) to state therein a material fact required to be stated therein or
necessary to make the statements therein not misleading, in light of the
circumstances in which they were made, and will reimburse the Company, such
directors and officers, each underwriter of the Registrable Securities and each
person controlling the Company for reasonable legal and any other expenses
reasonably incurred in connection with investigating or defending any such
claim, loss, damage, liability or action as incurred, in each case to the
extent, but only to the extent, that such untrue statement or omission or
allegation thereof is made in reliance upon and in conformity with written
information furnished to the Company by or on behalf of the Holder and stated to
be specifically for use in preparation of such registration statement,
prospectus or offering circular; provided that the indemnity shall not apply to
the extent that such claim, loss, damage or liability results from the fact that
a current copy of the prospectus was not made available to the Holder and such
current copy of the prospectus would have cured the defect giving rise to such
loss, claim, damage or liability. Notwithstanding the foregoing, in no event
shall a Holder be liable for any such claims, losses, damages or liabilities in
excess of the proceeds received by such Holder in the offering, except in the
event of fraud by such Holder.

                  (c) Each party entitled to indemnification under this Section
12.7 (the "Indemnified Party") shall give notice to the party required to
provide indemnification (the "Indemnifying Party") promptly after such
Indemnified Party has actual knowledge of any claim as to which indemnity may be
sought, and shall permit the Indemnifying Party to assume the defense of any
such claim or any litigation resulting therefrom, provided that counsel for the
Indemnifying Party, who shall conduct the defense of such claim or litigation,
shall be approved by the Indemnified Party (whose approval shall not
unreasonably be withheld), and the Indemnified Party may participate in such
defense at such Indemnified Party's expense, and provided further that the
failure of any Indemnified Party to give notice as provided herein shall not
relieve the Indemnifying Party of its obligations under this Agreement, unless
such failure is materially prejudicial to the Indemnifying Party in defending
such claim or litigation. An

                                     - 38 -
<PAGE>

Indemnifying Party shall not be liable for any settlement of an action or
claim effected without its written consent (which consent will not be
unreasonably withheld).

                  (d) If the indemnification provided for in this Section 12.7
is held by a court of competent jurisdiction to be unavailable to an Indemnified
Party with respect to any loss, liability, claim, damage or expense referred to
therein, then the Indemnifying Party, in lieu of indemnifying such Indemnified
Party thereunder, shall contribute to the amount paid or payable by such
Indemnified Party as a result of such loss, liability, claim, damage or expense
in such proportion as is appropriate to reflect the relative fault of the
Indemnifying Party on the one hand and of the Indemnified Party on the other in
connection with the statements or omissions which resulted in such loss,
liability, claim, damage or expense as well as any other relevant equitable
considerations. The relative fault of the Indemnifying Party and of the
Indemnified Party shall be determined by reference to, among other things,
whether the untrue or alleged untrue statement of a material fact or the
omission to state a material fact relates to information supplied by the
Indemnifying Party or by the Indemnified Party and the parties' relative intent,
knowledge, access to information and opportunity to correct or prevent such
statement or omission.

                  12.8. (a) Each Holder agrees that, upon receipt of any notice
from the Company of the happening of any event requiring the preparation of a
supplement or amendment to a prospectus relating to Registrable Securities so
that, as thereafter delivered to the Holders, such prospectus will not contain
an untrue statement of a material fact or omit to state any material fact
required to be stated therein or necessary to make the statements therein not
misleading, each Holder will forthwith discontinue disposition of Registrable
Securities pursuant to the registration statement contemplated by Section 12.2
until its receipt of copies of the supplemented or amended prospectus from the
Company and, if so directed by the Company, each Holder shall deliver to the
Company all copies, other than permanent file copies then in such Holder's
possession, of the prospectus covering such Registrable Securities current at
the time of receipt of such notice.

                  (b) As a condition to the inclusion of its Registrable
Securities, each Holder shall furnish to the Company such information regarding
such Holder and the distribution proposed by such Holder as the Company may
request in writing or as shall be required in connection with any registration,
qualification or compliance referred to in this Article 12.

                  (c) Each Holder hereby covenants with the Company (i) not to
make any sale of the Registrable Securities without effectively causing the
prospectus delivery requirements under the Securities Act to be satisfied, and
(ii) if such Registrable Securities are to be sold by any method or in any
transaction other than on a national securities exchange, the Nasdaq National
Market, Nasdaq SmallCap Market or in the over-the-counter market, in privately

                                     - 39 -
<PAGE>

negotiated transactions, or in a combination of such methods, to notify the
Company at least five (5) business days prior to the date on which the Holder
fast offers to sell any such Registrable Securities.

                  (d) Each Holder acknowledges and agrees that the Registrable
Securities sold pursuant to the Registration Statement described in this Article
12 are not transferable on the books of the Company unless the stock certificate
submitted to the transfer agent evidencing such Registrable Securities is
accompanied by a certificate reasonably satisfactory to the Company to the
effect that (i) the Registrable Securities have been sold in accordance with
such Registration Statement and (ii) the requirement of delivering a current
prospectus has been satisfied.

                  (e) Each Holder shall not take any action with respect to any
distribution deemed to be made pursuant to such registration statement, which
would constitute a violation of Regulation M under the Securities Exchange Act
of 1934, as amended (the "Exchange Act") or any other applicable rule,
regulation or law.

                  (f) At the end of the period during which the Company is
obligated to keep the Registration Statement current and effective as described
above, the Holders of Registrable Securities included in the Registration
Statement shall discontinue sales of shares pursuant to such Registration
Statement upon receipt of notice from the Company of its intention to remove
from registration the shares covered by such Registration Statement which remain
unsold, and such Holders shall notify the Company of the number of shares
registered which remain unsold immediately upon receipt of such notice from the
Company.

                  12.9. With a view to making available to the Holders the
benefits of certain rules and regulations of the Securities and Exchange
Commission which at any time permit the sale of the Registrable Securities to
the public without registration, the Company shall use its reasonable best
efforts:

                  (a) to make and keep public information available, as those
terms are understood and defined in Rule 144 under the Securities Act, at all
times;

                  (b) to file with the Securities and Exchange Commission in a
timely manner all reports and other documents required of the Company under the
Exchange Act; and

                  (c) so long as a Holder owns any unregistered Registrable
Securities, to furnish to such Holder upon any reasonable request a written
statement by the Company as to its compliance with Rule 144 under the Securities
Act, and of the Exchange Act, a copy of the most recent annual or quarterly
report of the Company, and such other reports and documents of the

                                     - 40 -
<PAGE>

Company as such Holder may reasonably request in availing itself of any rule or
regulation of the Securities and Exchange Commission allowing a Holder to sell
any such securities without registration.

                  12.10. The rights to cause the Company to register Registrable
Securities granted to the Holders by the Company under Section 12.2 may be
assigned in full by a Holder in connection with a transfer by such Holder of its
Registrable Securities, provided that (i) such transfer may otherwise be
effected in accordance with applicable securities laws; (ii) such transfer
involves not less than the lesser of all or 5,000 shares of such Holder's
Registrable Securities, (iii) such Holder gives prior written notice to the
Company; and (iv) such transferee agrees to comply with the terms and provisions
of this Agreement, and such transfer is otherwise in compliance with this
Agreement. Except as specifically permitted by this Section 12.10, the rights of
a Holder with respect to Registrable Securities as set out herein shall not be
transferable to any other Person, and any attempted transfer shall cause all
rights of such Holder therein to be forfeited.

                  12.11. With the written consent of the Company and the Holders
holding at least a majority of the Registrable Securities that are then
outstanding, any provision of this Article 12 may be waived (either generally or
in a particular instance, either retroactively or prospectively and either for a
specified period of time or indefinitely) or amended. Upon the effectuation of
each such waiver or amendment, the Company shall promptly give written notice
thereof to the Holders, if any, who have not previously received notice thereof
or consented thereto in writing. Notwithstanding the foregoing or Section 13.1,
a waiver or consent to depart from the provisions hereof with respect to a
matter that relates exclusively to the rights of the Holders of Common Stock
being sold pursuant to the Registration Statement and that does not directly or
indirectly affect the rights of other Holders may be given by Holders of a
majority of the shares of Common Stock included among such shares being sold.

         13.      MISCELLANEOUS.

                  13.1. AMENDMENTS AND WAIVERS. (a) This Agreement and all
exhibits and schedules hereto set forth the entire agreement and understanding
among the parties as to the subject matter hereof and merges and supersedes all
prior discussions, agreements and understandings of any and every nature among
them. This Agreement may be amended only by mutual written agreement of the
Company and either by the holders of at least fifty percent (50%) or more in
principal amount of outstanding Notes (or, in the case of the Alternative
Offering, of the Common Stock included in the Alternative Equity Units sold in
such offering) or by the Secured Party, and the Company may take any action
herein prohibited or omit to take any action herein required to be performed by
it, and any breach of any covenant, agreement, warranty or representation may be
waived, only if the Company has obtained the written consent

                                     - 41 -
<PAGE>

or waiver of the holders of at least fifty percent (50%) in principal
amount of outstanding Notes (or, in the case of the Alternative Offering,
of the Common Stock included in the Alternative Equity Units sold in such
offering) or of the Secured Party; provided. however, that the holders of
at least 50% in principal amount of Notes sold at any particular Closing (or of
at least 50 of the voting power of any securities underlying such Notes or of
the shares of Common Stock included in the Alternative Equity Units sold) may
amend this Agreement or consent to or waive any covenant, agreement, warranty or
representation on behalf of all Purchasers at such Closing that do not adversely
affect the securities sold to Purchasers at any other Closing or such other
Purchasers. No course of dealing between or among any persons having any
interest in this Agreement will be deemed effective to modify, amend or
discharge any part of this Agreement or any rights or obligations of any person
under or by reason of this Agreement. To secure a consent of the Holders under
this Section 13.1, it shall not be necessary for the holders to approve the
particular form of any proposed amendment or waiver, but it shall be sufficient
if such consent approves the substance thereof.

                  (b) Until an amendment or waiver becomes effective, a consent
to it by a holder of a Note or other security is a continuing consent by such
holder and every subsequent holder of a security or portion of a security that
evidences the same debt or other security as such consenting holder's security,
even if notation of the consent is not made on any security. However, prior to
becoming effective, any such holder or subsequent holder may revoke the consent
as to its securities or a portion thereof it the Company receives written notice
of revocation before the consent of holders of the requisite aggregate principal
amount of Notes or other security then outstanding has been obtained and not
revoked.

         The Company may, but shall not be obligated to, fix a record date
pursuant to paragraph (c) for the purpose of determining the holders entitled to
consent to any ,amendment or waiver. If a record date is fixed, then
notwithstanding the provisions of the immediately preceding paragraph, those
Persons who were holders at such record date (or their duly designated proxies),
and only those Persons, shall be entitled to consent to such amendment or waiver
or to revoke any consent previously given, whether or not such Persons continue
to be holders after such record date. After an amendment or waiver becomes
effective it shall bind every holder of a Note or other security. In such case,
the amendment or waiver shall bind each holder of a Note or other security who
has consented to it and every subsequent holder of a Note or other security that
evidences the same debt or other security as the consenting holder's Note or
other security.

                  (c) Whenever in this Agreement it is provided that the holders
of a specified percentage in aggregate principal amount of the Notes or other
security may take any action (including the making of any demand or request, the
giving of any notice, consent or waiver or the taking of any other action), the
fact that at the time of taking any such action, the holders of such specified
percentage have joined therein may be evidenced (i) by any instrument or any

                                     - 42 -
<PAGE>

number of instruments of similar tenor executed by holders in person or by proxy
appointed in writing or (ii) by the record of the holders voting in favor
thereof at any meeting of holders. Whenever the Company solicits the taking of
action by the holders, the Company may fix in advance of such solicitation a
date as the record date for determining holders entitled to take such action. If
a record date is fixed, those and only those Persons who are holders at the
record date so fixed, or their proxies, shall be entitled to take action
regardless of whether they are holders at the time of such action.

                  13.2. SUCCESSORS AND ASSIGN. Except as contemplated by Section
8.14, this Agreement may not be assigned by the Company except with the prior
written consent of the holders of a majority of outstanding principal amount of
the Notes or number of shares of Common Stock included in the Alternative Equity
Units. This Agreement shall be binding upon and inure to the benefit of the
Company and its permitted successors and assigns and Purchasers and their
successors and registered assigns. The provisions hereof which are for
Purchasers' benefit as purchasers or holders of the Notes are also for the
benefit of, and enforceable by, any subsequent registered holder of such Notes.

                  13.3. NOTICES. All notices, demands and other communications
to be given or delivered under or by reason of the provisions of this Agreement
shall be in writing and shall be deemed to have been given personally or when
mailed by certified or registered mail, return receipt requested and postage
prepaid, and addressed to the addresses of the respective parties set forth
below or to such changed addresses as such parties may have fixed by notice;
provided, however, that any notice of change of address shall be effective only
upon receipt:

                           If to the Company:

                           Hybridon, Inc.
                           620 Memorial Drive
                           Cambridge, MA 02139
                           Attn: E. Andrews Grinstead, III

                           If to Purchasers:

                           c/o Amir Tabbah
                           28 Avenue de Messine
                           75008 Paris, France

                  13.4. GOVERNING LAW. The validity, performance, construction
and effect of this Agreement shall be governed by the internal laws of the State
of New York without giving effect to such State's principles of conflict of
laws.

                                     - 43 -
<PAGE>

                  13.5. COUNTERPARTS. This Agreement may be executed in any
number of counterparts and, notwithstanding that any of the parties did not
execute the same counterpart, each of such counterparts (and facsimile copies
thereof, if electronically delivered to the Placement Agent) shall, for all
purposes, be deemed an original, and all such counterparts shall constitute one
and the same instrument binding on all of the parties hereto. Delivery of an
executed counterpart of a signature page to this Agreement by telecopier shall
be as effective as delivery of a manually executed counterpart of a signature
page of this Agreement.

                  13.6. HEADINGS. The headings of the Sections hereof are
inserted as a matter of convenience and for reference only and in no way define,
limit or describe the scope of this Agreement or the meaning of any provision
hereof.

                  13.7. SEVERABILITY. In the event that any provision of this
Agreement or the application of any provision hereof is declared to be illegal,
invalid or otherwise unenforceable by a court of competent jurisdiction, the
remainder of this Agreement shall not be affected except to the extent necessary
to delete such illegal, invalid or unenforceable provision unless the provision
held invalid shall substantially impair the benefit of the remaining portion of
this Agreement.

                  13.8. EXCULPATION AMONG, PURCHASERS. Each Purchaser
acknowledges and agrees that it is not relying upon any other Purchaser, or any
officer, director, employee partner or affiliate of any such other Purchaser, in
making its investment or decision to invest in the Company or in monitoring such
investment. Each Purchaser agrees that no Purchaser nor any controlling person,
officer, director, stockholder, partner, agent or employee of any Purchaser
shall be liable for any action heretofore or hereafter taken or omitted to be
taken by any of them relating to or in connection with the Company or the
securities, or both.

                  13.9. ACTIONS BY PURCHASERS. Any actions permitted to be taken
by holders or Purchasers of Notes (or subgroups thereof, as contemplated by
Section 13.1 ("Consenting Subgroups")) and any consents required to be obtained
from the same under this Agreement, may be taken or given only by holders of at
least fifty percent (50c) in principal amount of outstanding Notes (or as
otherwise provided in Section 13.1 with respect to Consenting Subgroups) and if
such holders or Purchasers constituting at least fifty percent (50%) (the
"Majority Purchasers") take any action or grant any consent, such action or
consent shall be deemed given or taken by all holders or Purchasers' who shall
be bound by the decision or action taken by the Majority Purchasers without any
liability on the part of the Majority Purchasers to any other holder or
Purchasers of securities hereunder. This provision shall apply MUTATIS MUTANDIS
to the Alternative Offering.

                                     - 44 -

<PAGE>

                  13.10. LIQUIDATION PUT. (a) Subject to the following
provisions of this Section 13. 10, each Purchaser may require the Company to
repurchase with cash (the "Liquidation Put") each of the shares of Common Stock
included in the Alternative Equity Units purchased by such Purchaser.

                  (b) Each Purchaser covenants not to exercise the Liquidation
Put unless (a) the Company liquidates, dissolves or winds up its affairs
pursuant to applicable bankruptcy law, whether voluntarily or involuntarily, (b)
all of the securities issued under the Indenture relating to the 9 % Notes
referred to under the caption "Equity Capitalization and Indebtedness -- 9
Convertible Subordinated Notes Due 2004" in the Term Sheet have been paid in
full and no obligations remain under such Indenture, (c) all other indebtedness
and obligations of the Company (including, without limitation, the indebtedness
under the Company's loan agreement with Silicon Valley Bank) has been paid in
full, and (d) all rights of the holders of any series or class of capital stock
ranking prior and senior to the Common Stock with respect to liquidation have
been satisfied in full.

                  (c) The Liquidation Put right is not transferable. Any
purported transfer of the Liquidation Put right shall be null and void and shall
result in a forfeiture of the rights set forth in this Section 13.10.

                  (d) At any time after the fast anniversary of the Final
Closing Date, the Company may cause the Liquidation Put right to be terminated
if the last sale price of the Common Stock shall have exceeded 200% of the
Common Stock Offering Price for the 20 consecutive trading days prior to the
date of notice of termination. No greater than 60 nor fewer than 20 days prior
to the date of any such mandatory termination, notice by first class mail,
postage prepaid, shall be given to the Purchasers, addressed to such Purchasers
as provided in Section 13.3. Each such notice shall specify the date fixed for
termination. Any notice which is mailed as herein provided shall be conclusively
presumed to have been duly given by the Company on the date hand-delivered or
deposited in the U.S. Mail, whether or not any Purchaser receives such notice;
and failure properly to give such notice, or any defect in such notice, to any
Purchaser shall not affect the validity of the proceedings for the termination
in any respect.

                  (e) With the written consent of the Company and the Purchasers
holding at least a majority of the issued and outstanding Common Stock subject
to a Liquidation Put, any provision of this Section 13.10 may be waived (either
generally or in a particular instance, either retroactively or prospectively and
either for a specified period of time or indefinitely) or amended. Upon the
effectuation of each such waiver or amendment, the Company shall promptly give
written notice thereof to the Purchasers, if any, who have not previously
received notice thereof or consented thereto in writing in the manner provided
in Section 13.10(d).

                                     - 45 -
<PAGE>

                  13.11. ADDITIONAL PURCHASERS. Upon the execution and delivery
by any Person of this Agreement after the date hereof with the written consent
of the Company, such Person shall be referred to as an Additional Purchaser and
shall become a Purchaser, and each reference in this Agreement to "Purchaser"
shall also mean and be a reference to such Additional Purchaser.

         14. CONFIDENTIAL INVESTOR QUESTIONNAIRE.

                  14.1. Each Purchaser represents and warrants that he, she or
it comes within one of category A through H below. ALL INFORMATION IN RESPONSE
TO THIS SECTION WILL BE KEPT STRICTLY CONFIDENTIAL. The undersigned agrees to
furnish any additional information which the Company deems necessary in order to
verify the answers set forth below.

Category A:                   The undersigned is an individual (not a
                              partnership, corporation, etc.) whose individual
                              net worth, or joint net worth with his or her
                              spouse, presently exceeds $1,000,000.

                              EXPLANATION. In calculating net worth you may
                              include equity in personal property and real
                              estate, including your principal residence, cash,
                              short-term investments, stock and securities.
                              Equity in personal property and real estate should
                              be based on the fair market value of such property
                              less debt secured by such property.

Category B:                   The undersigned is an individual (not a
                              partnership, corporation, etc.) who had an
                              individual income in excess of $200,000 in each
                              of the two most recent years, or joint income
                              with his or her spouse in excess of $300,000 in
                              each of those years (in each case including
                              foreign income, tax exempt income and full amount
                              of capital gains and losses but excluding any
                              income of other family members and any unrealized
                              capital appreciation) and has a reasonable
                              expectation of reaching the same income level in
                              the current year.

Category C:                   The undersigned is a director or executive
                              officer of the Company which is issuing and
                              selling the Units.

Category D:                   The undersigned is a bank; a savings and loan
                              association; insurance company; registered
                              investment company; registered business
                              development company; licensed small business
                              investment company ("SBIC"); or employee benefit
                              plan within the meaning of Title 1 of

                                     - 46 -
<PAGE>

                              ERISA and (a) the investment decision is made by
                              a plan fiduciary which is either a bank, savings
                              and loan association, insurance company or
                              registered investment advisor, or (b) the plan
                              has total assets in excess of $5,000,000 or is a
                              self directed plan with investment decisions made
                              solely by persons that are accredited investors.

Category E:                   E: The undersigned is a private business
                              development company as defined in section
                              202(a)(22) of the Investment Advisors Act of 1940.

Category F:                   F: The undersigned is either a corporation,
                              partnership, Massachusetts business trust, or
                              non-profit organization within the meaning of
                              Section 501(c)(3) of the Internal Revenue Code, in
                              each case not formed for the specific purpose of
                              acquiring the Units and with total assets in
                              excess of $5,000,000.

Category G:                   G: The undersigned is a trust with total assets in
                              excess of $5,000,000, not formed for the specific
                              purpose of acquiring the Units, where the purchase
                              is directed by a "sophisticated person" as defined
                              in Regulation 506(b)(2)(ii) under the Securities
                              Act.

Category H:                   H: The undersigned is an entity (other than a
                              trust) all the equity owners of which are
                              "accredited investors" within one or more of the
                              above categories. If relying upon this Category
                              alone, each equity owner must complete a separate
                              copy of this Agreement.

The undersigned agrees that the undersigned will notify the Company at any time
on or prior to the Final Closing Date in the event that the representations and
warranties in this Agreement shall cease to be true, accurate and complete.

                  14.2. MANNER IN WHICH TITLE IS TO BE HELD. (circle one)

                  (a) Individual Ownership

                  (b) Community Property

                  (c) Joint Tenant with Right of Survivorship (both parties must
                      sign)

                  (d) Partnership*

                  (e) Tenants in Common

                                     - 47 -
<PAGE>

                  (f) Company*

                  (g) Trust*

                  (h) Other

         *If Units are being subscribed for by an entity, the attached
Certificate of Signatory must also be completed.

                  14.3. NASD Affiliation.

Are you affiliated or associated with an NASD member firm (please check one):

Yes ____________  No ____________

If Yes, please describe:

________________________________________________________________________________

________________________________________________________________________________

________________________________________________________________________________

*If Purchaser is a Registered Representative with an NASD member firm, have the
following acknowledgment signed by the appropriate party:

The undersigned NASD member firm acknowledges receipt of the notice required by
Article 3, Sections 28(a) and (b) of the Rules of Fair Practice.

----------------------------------------
Name of NASD Member Firm

By:
    ------------------------------------
         Authorized Officer

Date:
      ----------------------------------

                  14.4. RELIANCE ON CONFIDENTIAL INVESTOR QUESTIONNAIRE. The
undersigned is informed of the significance to the Company of the foregoing
representations and answers contained in the Confidential Investor Questionnaire
contained in this Article 14 and such answers have been provided under the
assumption that the Company will rely on them.

         IN WITNESS WHEREOF, the parties hereto have executed this Agreement as
of the day and year indicated.

                                     - 48 -
<PAGE>

                       [Signature Page for each Purchaser]

___________ Units at $ 100,000 per Unit, or an aggregate of $__________ (the

"Purchase Price")

By its execution and delivery of this signature page, the undersigned Purchaser
hereby joins in and agrees to be bound by the terms and conditions of the Unit
Purchase Agreement (the "Purchase Agreement") by and among Hybridon, Inc. (the
"Company") and the Purchasers (as defined therein), as to the aggregate number
of Units set forth above and authorizes this signature page to be attached to
the Purchase Agreement or counterparts thereof.

-----------------------------------        -------------------------------------
Signature                                  Signature (if purchasing jointly)

-----------------------------------        -------------------------------------
Name Typed or Printed                      Name Typed or Printed

-----------------------------------        -------------------------------------
Entity Name                                Entity Name

-----------------------------------        -------------------------------------
Address                                    Address

-----------------------------------        -------------------------------------
City, State and Zip Code                   City, State and Zip Code

-----------------------------------        -------------------------------------
Telephone-Business                         Telephone--Business

-----------------------------------        -------------------------------------
Telephone-Residence                        Telephone--Residence

-----------------------------------        -------------------------------------

                                     - 49 -
<PAGE>

Facsimile-Business                         Facsimile--Business

-----------------------------------        -------------------------------------
Facsimile-Residence                        Facsimile--Residence

-----------------------------------        -------------------------------------
Tax ID # or Social Security #              Tax ID # or Social Security #

Dated: _______________ ____, 1998

         This Agreement is agreed to and accepted as of       , 1998.

                                             HYBRIDON, INC.

                                             By:
                                                 -------------------------------
                                             Name:
                                             Title:

                                     - 50 -

<PAGE>

THE TERMS OF THIS NOTE ARE SUBJECT TO THE TERMS OF A UNIT PURCHASE AGREEMENT, A
COPY OF WHICH IS AVAILABLE FROM HYBRIDON, INC. (THE "COMPANY"). THE SECURITIES
REPRESENTED BY THIS NOTE HAVE NOT BEEN REGISTERED UNDER THE UNITED STATES
SECURITIES ACT OF 1933, AS AMENDED (THE "SECURITIES ACT"), OR ANY APPLICABLE
STATE SECURITIES LAWS, AND MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED OR
HYPOTHECATED OR OTHERWISE TRANSFERRED IN THE ABSENCE OF A REGISTRATION STATEMENT
IN EFFECT WITH RESPECT TO THE SECURITIES UNDER THE SECURITIES ACT OR AN
EXEMPTION FROM THE SECURITIES ACT. ANY SUCH TRANSFER MAY ALSO BE SUBJECT TO
COMPLIANCE WITH APPLICABLE STATE SECURITIES LAWS AND THE LAWS OF OTHER
APPLICABLE JURISDICTIONS.

THIS NOTE MAY NOT BE OFFERED OR SOLD IN THE UNITED STATES OR TO A U.S. PERSON OR
FOR THE ACCOUNT OR BENEFIT OF A U.S. PERSON PRIOR TO THE EXPIRATION OF THE
RESTRICTED PERIOD (AS DEFINED IN THE PURCHASE AGREEMENT), AND NO TRANSFER OR
EXCHANGE OF THIS NOTE MAY BE MADE UNTIL AFTER THE LATER OF THE DATE OF
EXPIRATION OF THE RESTRICTED PERIOD AND THE DATE ON WHICH THE REQUIRED
CERTIFICATION RELATING TO SUCH INTEREST HAS BEEN PROVIDED IN ACCORDANCE WITH THE
TERMS OF THE PURCHASE AGREEMENT.

                                 HYBRIDON, INC.

                                 NOTE DUE 2007

                                                                       No. _____

$ ___________

                                                              [DATE OF ISSUANCE]

         Hybridon, Inc., a Delaware corporation, (the "Company"), for value
received, hereby promises to pay to ____________________ (the "Holder"), or
registered assigns, the principal sum set forth above, with accrued but unpaid
interest thereon at a rate equal to fourteen percent (14%) per annum, on
December 31, 2007 (the "Maturity Date"); provided, however, that if the offering
(the "Unit Offering") of units ("Units") consisting of Notes (as defined below)
and Warrants is terminated before the Mandatory Conversion Event (as defined
below) has occurred, then the interest rate will increase to eighteen percent
(18%) per annum, effective as of the date the Additional Warrants become
exercisable. Payment shall be made at such place as designated by the Company
upon surrender of this Note, and shall be in such coin or currency of the United
States of America as at the time of payment shall be legal tender for the
payment of public and private debts. This Note is one of a duly authorized issue
of Hybridon, Inc. Notes due 2007 (individually a "Note" and collectively the
"Notes") in an aggregate original principal amount of up to $68,750,000 plus any
Notes issued in lieu of cash interest on Notes, issued pursuant to a

<PAGE>

Unit Purchase Agreement which is available from the Company (the "Purchase
Agreement") and similar agreements. The Notes shall be senior in right of
payment to the Company's 9% Convertible Subordinated Notes Due 2004 (the "9%
Notes") to the extent provided in a First Supplemental Indenture, dated as of
January 13, 1998, to an Indenture, dated as of March 26, 1997, pursuant to which
such 9% Notes were issued. The Notes shall be subordinated in right of payment
to all existing and future Senior Indebtedness of the Company. The Notes are
secured by certain assets of the Company pursuant to the Purchase Agreement on a
subordinated basis. Capitalized terms used herein without definition have the
respective meanings specified therefor in the Purchase Agreement.

SECTION 1. INTEREST.

         The Company will pay interest semi-annually in arrears on April 1 and
October 1 of each year (each an "Interest Payment Date"), or if any such day is
not a Business Day, on the next succeeding Business Day to the registered Holder
hereof as of the preceding March 15 or September 15 (each, a "Record Date").
Interest on this Note will accrue from the most recent Interest Payment Date to
which interest has been paid or, if no interest has been paid, from the date of
its issuance set forth above; provided that if there is no existing Default in
the payment of interest, and if this Note is authenticated between a Record
Date, and the next succeeding Interest Payment Date, interest shall accrue from
such next succeeding Interest Payment Date; provided, further, that the first
Interest Payment Date shall be April 1, 1998 or, if interest is paid in cash,
October 1, 1998. The Company may, with respect to each Interest Payment Date, at
its option and in its sole discretion, in lieu of payment of interest on the
Notes in cash, issue additional Notes ("Interest Notes") in an aggregate
principal amount equal to the amount of interest not paid in cash on such
Interest Payment Date. Each issuance of Interest Notes in lieu of the payment of
cash interest on the Notes shall be made pro rata with respect to the
outstanding Notes; provided, however, that the Company may at its option pay
cash in lieu of issuing Interest Notes in any denomination of less than $1,000.
Interest will be computed on the basis of a 360-day year comprised of twelve
30-day months.

SECTION 2. PREPAYMENT.

         This Note (including interest accrued on the principal hereof) may be
prepaid by the Company, at any time without penalty or premium.

SECTION 3. MANDATORY CONVERSION.

                  (a) MANDATORY CONVERSION. Upon the occurrence of a Mandatory
Conversion Event (as hereinafter defined), and not before such occurrence under
any circumstances, the Notes and all accrued interest thereon shall
automatically convert into the number of shares of Series B Preferred Stock of
the Company in substantially the form attached to the Purchase Agreement as
Exhibit C (the "Conversion Securities") equal to the Conversion Amount (as
defined below) divided by the then current Conversion Price (as defined below).
The "Conversion Amount" shall be the Liquidation Amount (as defined below). The
"Liquidation Amount" shall be the aggregate principal amount of, plus any
accrued but unpaid interest on, the Notes held by such Holder. The "Conversion
Price" shall initially be $100, subject to adjustment

                                     - 52-
<PAGE>

as provided below, representing an initial conversion rate (subject to
adjustment) of 10 shares of Conversion Securities per $1,000 of Conversion
Amount (the "Conversion Rate").

         A "Mandatory Conversion Event" shall be deemed to have occurred,
effective immediately, when all of the following shall have occurred:

                  (i) the holders of $40,000,000 or more in aggregate principal
amount of the 9 % Convertible Subordinated Notes due 2004 (the "Subordinated
Notes") issued pursuant to the Indenture between the Company and State Street
Bank and Trust Company, as Trustee, dated as of March 26, 1997 (the
"Indenture"), irrevocably exchange such Subordinated Notes and all accrued but
unpaid interest thereon for Series A Preferred Stock of the Company and warrants
to purchase Common Stock of the Company; and

                  (ii) the Company has received proceeds in the Unit Offering,
net of cash fees, commissions and expenses, equal to or exceeding $20,000,000 in
the aggregate.

                  (b) CONVERSION PROCEDURES. Such conversion shall be deemed to
have been made automatically, irrevocably and immediately upon the occurrence of
a Mandatory Conversion Event and, upon such Mandatory Conversion Event, Notes
shall no longer be deemed outstanding and all rights whatsoever in respect
thereof (including the right to receive interest thereon) shall terminate except
as provided in the following sentence. The Company shall deliver to each Holder
certificates evidencing the number of full shares of Conversion Securities to
which such person shall be entitled as- provided in Subsection 3(a), subject to
Section 4 hereof.

                  (c) [Reserved]

                  (d) RESERVATION OF SHARES; TRANSFER TAXES; ETC. The Company
shall at all times reserve and keep available, out of its authorized and
unissued shares of Conversion Securities, solely for the purpose of effecting
the conversion of the Notes, such number of shares of its Conversion Securities
free of preemptive rights as shall be sufficient to effect the conversion of all
Notes from time to time outstanding. The Company shall use its best efforts from
time to time, in accordance with the laws of the State of Delaware, to increase
the authorized number of shares of Conversion Securities if at any time the
number of shares of Conversion Securities not outstanding shall not be
sufficient to permit the conversion of all the then-outstanding Notes.

         The Company shall pay any and all issue or other taxes (other than
income taxes) that may be payable in respect of any issue or delivery of shares
of Conversion Securities on conversion of the Notes. The Company shall not,
however, be required to pay any tax which may be payable in respect of any
transfer involved in the issue or delivery of Conversion Securities (or other
securities or assets) in a name other than that in which the Notes so converted
were registered, and no such issue or delivery shall be made unless and until
the person requesting such issue has paid to the Company the amount of such tax
or has established, to the satisfaction of the Company, that such tax has been
paid.

                                     - 53 -
<PAGE>

                  (e) OTHER CHANGES IN CONVERSION RATE. The Company from time to
time may increase the Conversion Rate by any amount for any period of time if
the period is at least 20 days and if the increase is irrevocable during the
period. Whenever the Conversion Rate is so increased, the Company shall mail to
the holder of record of this Note a notice of the increase at least 15 days
before the date the increased Conversion Rate takes effect, and such notice
shall state the increased Conversion Rate and the period it will be in effect.

         The Company may make such increases in the Conversion Rate, in addition
to those required or allowed by this paragraph (e), as shall be determined by
it, as evidenced by a resolution of the Board of Directors of the Company, to be
advisable in order to avoid or diminish any income tax to holders of Common
Stock resulting from any dividend or distribution of stock or issuance of rights
or warrants to purchase or subscribe for stock or from any event treated as such
for income tax purposes.

SECTION 4. FRACTIONAL SHARES.

         The Company shall not be required to issue fractions of shares of
Conversion Securities or other capital stock of the Company upon conversion of
any Notes. If any fraction of a share would be issuable on conversion of any
Notes (aggregating, for this purpose, all Notes held by a record holder), the
number of shares of Conversion Securities issuable shall be rounded to the
nearest whole share, with .5 of a share rounded upward.

SECTION 5. EVENTS OF DEFAULT DEFINED.

         The following shall each constitute an "Event of Default" hereunder:

                  (a) the failure of the Company to make any payment of (i)
principal of this Note when due and payable and such failure shall continue for
five (5) or more days and (ii) interest on this Note when due and payable and
such failure shall continue for thirty (30) or more days, whether or not such
payment is prohibited by the subordination provisions of this Note or the
Purchase Agreement;

                  (b) the failure of the Company to observe or perform any
covenant in this Note or in the Purchase Agreement, and such failure shall have
continued unremedied for a period of sixty (60) days after written notice as
provided in the last paragraph of this Section 5;

                  (c) a default occurs (after giving effect to any applicable
grace periods or any extension of any maturity date) in the payment when due of
principal of, or an acceleration of, any indebtedness for money borrowed by the
Company or any of its Subsidiaries (other than an Unrestricted Subsidiary (as
defined below) which is not a Significant Subsidiary and provided there is no
recourse against the Company or any other Subsidiary with respect to the
obligations of such Unrestricted Subsidiary arising as a result of such default)
in excess of $2 million, individually or in the aggregate, if such indebtedness
is not discharged, or such acceleration is not annulled, within 30 days after
written notice as provided in the last paragraph of this Section 5;

                                     - 54 -
<PAGE>

                  (d) the Company or any of its Significant Subsidiaries,
pursuant to or within the meaning of any Bankruptcy Law:

                  (i) commences a voluntary case,

                  (ii) consents to the entry of an order for relief against it
in an involuntary case,

                  (iii) consents to the appointment of a Custodian of it or for
all or substantially all of its property, and such Custodian is not discharged
within 30 days,

                  (iv) makes a general assignment for the benefit of its
creditors, or

                  (v) admits in writing that it is generally unable to pay its
debts as the same become due;

                  (e) a court of competent jurisdiction enters and order or
decree under any Bankruptcy Law that:

                  (i) is for relief in any involuntary case against the Company
or any Significant Subsidiary,

                  (ii) appoints a Custodian of the Company or any Significant
Subsidiary or for all or substantially all of the property of the Company or any
Significant Subsidiary, or

                  (iii) orders the liquidation of the Company or any Significant
Subsidiary, and, in each case, the order or decree remains unstayed and in
effect for 60 consecutive days.

         The term "Bankruptcy Law" means Title 11 of the U.S. Code or any
similar federal, foreign or state law for the relief of debtors. The term
"Custodian" means any receiver, trustee, assignee, liquidator, examiner or
similar official under any Bankruptcy Law. The term "Significant Subsidiary" has
the same meaning as significant subsidiary has under Regulation S-X under the
Securities Act as in effect on the date hereof. "Unrestricted Subsidiary" means
any Subsidiary of the Company which (i) is not wholly-owned by the Company, (ii)
is designated as an Unrestricted Subsidiary by the Board of Directors of the
Company and (iii) at the time of any investment by the Company in such
Subsidiary, in the aggregate holds or comprises less than 20% of the Company's
assets as shown on the Company's consolidated balance sheet prepared in
accordance with generally accepted accounting principles consistently applied as
at the time of such investment.

         A Default under Subsection (b) of this Section 5 (other than a Default
under Section 8.14 of the Purchase Agreement, which Default shall be an Event of
Default with the notice but without the passage of time specified in Subsection
(b) of this Section 5) or Subsection (c) of this Section 5 shall not be an Event
of Default until (i) the holders of at least 25 % in aggregate principal amount
of the Notes then outstanding shall have notified the Company of the Default and
(ii) the Company shall have failed to cure the Default under such Subsection (b)
within 60 days after receipt of the notice or under such Subsection (c) within
10 days after receipt of the

                                     - 55 -
<PAGE>

notice, respectively. Any such notice must specify the Default, demand that it
be remedied and state that the notice is a "Notice of Default."

SECTION 6. REMEDIES UPON EVENT OF DEFAULT.

                  (a) If an Event of Default (other than an Event of Default
specified in Subsections (d) and (e) of Section 5) occurs and is continuing, the
Holders of at least 25% in aggregate principal amount of the Notes then
outstanding (by notice to the Company and the Secured Party), may declare the
unpaid principal of and accrued interest on all the Notes then outstanding to be
due and payable. Upon any such declaration, such principal and accrued interest
shall be due and payable immediately. If an Event of Default specified in
Subsection (d) or (e) of Section 5 occurs, such an amount shall ipso facto
become and be immediately due and payable without any declaration or other act
on the part of any Holder. The Holders of at least fifty percent (50%) or more
in aggregate principal amount of the Notes then outstanding may rescind an
acceleration and its consequences if (a) the Company has paid a sum sufficient
to pay (i) all overdue interest on all Notes then outstanding and (ii) the
principal of the Notes then outstanding which have become due otherwise than by
such declaration of acceleration and accrued interest thereon at a rate borne by
the Notes and (b) the rescission would not conflict with any judgment or decree
and if all existing Events of Default have been cured or waived except
nonpayment of principal or interest that has become due solely because of
acceleration. No such rescission shall effect any subsequent Default or impair
any right consequent thereto.

                  (b) The Holders of at least fifty percent (50%) or more in
aggregate principal amount of the Notes then outstanding may waive an existing
Default or Event of Default and its consequences. Upon any such waiver, such
Default shall cease to exist and any Event of Default arising therefrom shall be
deemed to have been cured for every purpose of this Note and the Purchase
Agreement; but no such waiver shall extend to any subsequent or other Default or
impair any right consequent thereon.

                  (c) If the Company defaults in a payment of interest on the
Notes, the Company shall pay defaulted interest (plus interest on such defaulted
interest, to the extent lawful, at the rate borne by this Note) in any lawful
manner. The Company shall pay the defaulted interest to the Holders of the Notes
on a special record date. The Company shall fix or cause to be fixed any such
special record date and payment date, which specified record date shall not be
less than 10 days prior to the payment date for such defaulted interest, and
shall promptly mail or cause to be mailed to each Holder a notice that states
the special record date, the payment date and the amount of defaulted interest
to be paid.

                  (d) No remedy herein conferred upon the Holder of this Note is
intended to be exclusive of any other remedy and each and every such remedy
shall be cumulative and shall be in addition to every other remedy given
hereunder or now or hereafter existing at law or in equity or by statute or
otherwise.

                  (e) In any suit for the enforcement of any right or remedy
under this Note or the Purchase Agreement, a court in its discretion may require
the filing by any party litigant in the suit of an undertaking to pay the costs
of the suit, and the court in its discretion may assess reasonable costs,
including reasonable attorneys' fees, against any party litigant in the suit,

                                     - 56 -
<PAGE>

having due regard to the merits and good faith of the claims or defenses made by
the party litigant. This Subsection 6(e) does not apply to a suit by Holders of
more than 10% in aggregate principal amount of the then outstanding Notes or any
suit for the enforcement of the mandatory conversion right set forth in Section
3.

SECTION 7.  NOTE REGISTER.

                  (a) The Company shall keep at its principal executive office a
register (herein sometimes referred to as the "Note Register"), in which,
subject to such reasonable regulations as it may prescribe, but at its expense
(other than transfer taxes, if any), the Company shall provide for the
registration and transfer of this Note.

                  (b) Whenever this Note shall be surrendered at the principal
executive office of the Company for transfer or exchange, accompanied by a
written instrument of transfer in form reasonably satisfactory to the Company
duly executed by the Holder hereof or his attorney duly authorized in writing,
and, subject to compliance with applicable securities laws, the Company shall
execute and deliver in exchange therefor a new Note or Notes, as may be
requested by such Holder, in the same aggregate unpaid principal amount and
payable on the same date as the principal amount of the Note or Notes so
surrendered; each such new Note shall be dated as of the date to which interest
has been paid on the unpaid principal amount of the Note or Notes so surrendered
and shall be in such principal amount and registered in such name or names as
such Holder may designate in writing.

                  (c) Upon receipt by the Company of evidence reasonably
satisfactory to it of the loss, theft, destruction or mutilation of this Note
and of indemnity reasonably satisfactory to it, and upon reimbursement to the
Company of all reasonable expenses incidental thereto, and upon surrender and
cancellation of this Note (in case of mutilation) the Company will make and
deliver in lieu of this Note a new Note of like tenor and unpaid principal
amount and dated as of the date to which interest has been paid on the unpaid
principal amount of this Note in lieu of which such new Note is made and
delivered.

SECTION 8. MISCELLANEOUS.

                  (a) AMENDMENTS AND WAIVERS. The holders of at least fifty
percent (50%) or more in principal amount of outstanding Notes or the Secured
Party on behalf of the holders of the Notes may waive or otherwise consent to
the amendment of any of the provisions hereof, provided that no such waiver or
amendment may reduce the principal amount of or interest on any of the Notes or
change the stated maturity of the principal or reduce the percentage of holders
of Notes necessary to waive or amend the provisions of this Note, without the
consent of each holder of any Note affected thereby.

                  (b) RESTRICTIONS ON TRANSFERABILITY. In addition to the
restrictions set forth in the Purchase Agreement, the securities represented by
this Note have been acquired for investment and have not been registered under
the Securities Act of 1933, as amended, or the securities laws of any state or
other jurisdiction. Without such registration, such securities may not be sold,
pledged, hypothecated or otherwise transferred, except pursuant to exemptions
from the Securities Act of 1933, as amended, and the securities laws of any
state or other jurisdiction.

                                     - 57 -
<PAGE>

                  (c) FORBEARANCE FROM SUIT. No holder of Notes shall institute
any suit or proceeding for the enforcement of the payment of principal or
interest unless the holders of at least 25 % in principal amount of all of the
outstanding Notes join in such suit or proceeding.

                  (d) NO RECOURSE AGAINST OTHERS. No directors, officer,
employee, incorporator or stockholder of the Company, as such, shall have any
liability for any obligations of the Company under this Note, the Purchase
Agreement or for any claim based on, in respect of, or by reason of, such
obligations or their creation. The Holder of this Note by accepting this Note
waives and releases all such liability. The waiver and release are part of the
consideration for the issuance of this Note.

                  (e) SUBORDINATION. The Holder by accepting this Note agrees
that the payment (by set-off or otherwise) of principal of and interest on the
Notes is subordinated in right of payment, to the extent and in the manner
provided in Section 9 of the Purchase Agreement, to the prior payment in full of
all obligations in respect of Senior Indebtedness of the Company, whether
outstanding on the date of the Purchase Agreement or thereafter incurred.

                  (f) DENOMINATIONS. This Note is issuable in minimum
denominations of $1,000 and integral multiples of $1,000 in excess thereof,
except as otherwise provided in Section 1 hereof.

                  (g) GOVERNING LAW. This Note shall be governed by, and
construed in accordance with, the laws of the State of New York, excluding the
body of law relating to conflict of laws. Notwithstanding anything to the
contrary contained herein, in no event may the effective rate of interest
collected or received by the Holder exceed that which may be charged, collected
or received by the Holder under applicable law.

                  (h) INTERPRETATION. If any term or provision of this Note
shall be held invalid, illegal or unenforceable, the validity of all other terms
and provisions hereof shall in no way be affected thereby.

                  (i) SUCCESSORS AND ASSIGNS. This Note shall be binding upon
the Company and its successors and assigns and shall inure to the benefit of the
Holder and its successors and registered assigns.

                  (j) NOTICES. All notices, requests, consents and demands shall
be made in writing and shall be mailed postage prepaid, or delivered by hand, to
the Company or to the Holder thereof at their respective addresses set forth
below or to such other address as may be furnished in writing to the other party
hereto:

       If to the Holder:     At the address shown on Schedule A attached
                             hereto

                                     - 58 -
<PAGE>

       If to the Company:    Hybridon, Inc.
                             620 Memorial Drive
                             Cambridge, Massachusetts 02139
                             Attention:  E. Andrews Grinstead, III

                  (k) SATURDAYS, SUNDAYS, HOLIDAYS. If any date that may at any
time be specified in this Note as a date for the making of any payment of
principal or interest under this Note shall fall on Saturday, Sunday or on a day
which in New York or Massachusetts or California shall be a legal holiday, then
the date for the making of that payment shall be the next subsequent day which
is not a Saturday, Sunday or legal holiday.

                  (l) PURCHASE AGREEMENT. This Note is subject to the terms
contained in the Purchase Agreement and the registered Holder of this Note is
entitled to the benefits of such Purchase Agreement to the extent provided
therein and may, in addition to any rights hereunder, enforce the agreements of
the Company contained therein and exercise the remedies provided for thereby or
otherwise available in respect thereof.

                  (m) NO ADVERSE INTERPRETATION OF OTHER AGREEMENTS. This Note
and the Purchase Agreement may not be used to interpret another note, indenture,
loan or debt agreement of the Company or a Subsidiary. Any such note, indenture,
loan or debt agreement may not be used to interpret this Note or the Purchase
Agreement.

         IN WITNESS WHEREOF, this Note has been executed and delivered on the
date fast above written by the duly authorized representative of the Company.

                                      HYBRIDON, INC.

                                      By: /s/ E. Andrews Grinstead, III
                                          --------------------------------------
                                          Name:
                                          Title:

                                     - 59 -

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