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Exhibit 10.11    
    

SIRTRIS
PHARMACEUTICALS, INC.

100 BEAVER STREET, SUITE 240

WALTHAM, MA 02453 

February 14,
2005 

Christoph
Westphal, M.D., Ph.D.

17 Hawes Street

Brookline, MA 02446 

Dear
Christoph: 

        This
letter agreement ("Agreement") will confirm our offer to you of employment with Sirtris Pharmaceuticals, Inc. (the "Company"), under the terms and conditions that follow: 

        1.    Position and Duties.    

        (a)    The Company.    Effective March 1, 2005, or such earlier date for which you give
us at least two days prior notice provided that the Board of Directors of the Company has approved this Agreement by such date (the "Effective Date"), you will be employed by the Company, on a
full-time basis, as its President and Chief Executive Officer, subject to the direction and control of the Board of Directors of the Company (the "Board"). In addition, you will serve
without further compensation as a member of the Board for so long as you serve as the Company's Chief Executive Officer, and will serve as the Vice Chairman of the Board until the Board determines
otherwise. You agree to perform the duties of your position and such other duties as reasonably may be assigned to you from time to time. You also agree that while employed by the Company, except as
provided in Section 1(b) below, you will
devote your full business time and your best efforts, business judgment, skill and knowledge exclusively to the advancement of the business and interests of the Company and to the discharge of your
duties and responsibilities for it. 

        (b)    Activities Outside the Company.    Until January 1, 2006, you may retain your
seat as a board member on the boards of directors of four companies. After January 1, 2006, you may serve as a member of the board of only three companies. You will, as a general rule, not
attend Board meetings of any other company. 

        Subject
to Section 4(f) hereof, you may remain a "venture partner" with Polaris IV and attend weekly partner meetings for two years following the Effective Date, or until the
Company files a Form S-1, whichever comes first, after which time you may retain the title of "venture partner" with Polaris but shall no longer attend such weekly meetings.
Furthermore, nothing herein shall require that you resign your position as a general partner of Polaris III which is fully invested at this time. 

        2.    Compensation and Benefits.    During your employment, as compensation for all services
performed by you for the Company and subject to your performance of your duties and responsibilities for the Company, pursuant to this Agreement or otherwise, the Company will provide you the
following pay and benefits: 

        (a)    Base Salary.    The Company will pay you a base salary at the rate of Three Hundred
Sixty Thousand Dollars ($360,000) per year, payable in accordance with the regular payroll practices of the Company for its executives, as in effect from time to time, and subject to increase from
time to time by the Board in its discretion. 

        (b)    Signing Bonus.    The Company will pay you a one-time signing bonus of
$120,000 plus an amount equal to $30,000 per month (pro rated for partial months) for each month following January 1, 2005 until the Effective Date of this Agreement, payable within
    days of your execution of this Agreement. 

        (c)    Bonus Compensation.    During your employment, you may be considered annually for a
bonus in addition to your base salary. Bonus compensation in any year, if any, will be determined 

 

by
the Board based on your performance and that of the Company, in accordance with a general executive bonus program to be established and agreed upon by you and the Board's Compensation Committee. 

        (c)    Restricted Common Stock.    At the next regular meeting of the Board following the
Effective Date, you will be awarded 2,000,000 shares of the restricted common stock of the Company at a purchase price of $0.001 per share (the "Restricted Shares"), pursuant to the Form of Stock
Restriction Agreement attached hereto as Exhibit A (the "Stock Restriction Agreement") and subject to all terms thereof. 400,000 of the
Restricted Shares shall vest as of the Effective Date. The remaining 1,600,000 of the Restricted Shares (the "Remainder Shares") will vest as follows: twenty-five percent (25%) of the
Remainder Shares shall vest on January 1, 2006, provided you are employed by the Company on that date, and the remainder of the Remainder Shares shall vest ratably, on a quarterly basis, on the
last date of each of the next twelve (12) quarters thereafter, provided that you remain in the Company's employ at each such vesting date. In addition, the Company will extend you credit in an
amount equal to the actual tax liability incurred by you in connection with your purchase of the Restricted Shares (provided that you have timely filed an 83(b) election the Internal Revenue Service),
pursuant the terms of the promissory note in the form attached hereto as Exhibit B and subject to all terms thereof. 

        (d)    Participation in Employee Benefit Plans.    You will be entitled to participate in all
employee benefit plans from time to time in effect for employees of the Company generally, except to the extent such plans are duplicative of benefits otherwise provided you under this Agreement
(e.g., severance pay) or under any other agreement. Your participation will be subject to the terms of the applicable plan documents and generally
applicable Company policies. 

        (e)    Vacations.    You will be entitled to three weeks paid vacation (or such greater amount
as is generally made available to the Company's executive officers) in accordance with the Company's policies from time to time in effect, in addition to holidays observed by the Company. Vacation may
be taken at such times and intervals as you shall determine, subject to the business needs of the Company, and otherwise shall be subject to the policies of the Company, as in effect from time to
time. 

        (f)    Business Expenses.    The Company will pay or reimburse you for all reasonable business
expenses incurred or paid by you in the performance of your duties and responsibilities for the Company, subject to any maximum annual limit and other restrictions on such expenses set by the Company
and to such reasonable substantiation and documentation as it may specify from time to time. 

        3.    Confidential Information, Non-Competition and Proprietary
Information.    Your employment with the Company is conditioned upon and subject to your agreement to the Company's Confidentiality, Non-Competition and
Proprietary Information Agreement, to be executed by you simultaneously herewith. It is understood and agreed that breach by you of the Confidential Information, Non-Competition and
Proprietary Information Agreement shall constitute a material breach of this Agreement. 

        4.    Termination of Employment.    Your employment under this Agreement shall continue until
terminated pursuant to this Section 4. 

        (a)   The
Company may terminate your employment for "Cause" upon notice to you setting forth in reasonable detail the nature of the Cause. The following, as determined by the
Board in its reasonable judgment, shall constitute Cause for termination: (i) your willful failure to perform, or gross negligence in the performance of, your duties and responsibilities to the
Company and its Affiliates which is not remedied within thirty (30) days of notice thereof; (ii) material breach by you of any material provision of this Agreement or any other agreement
with the Company or any 

2

 

of
its Affiliates which is not remedied within thirty (30) days of notice thereof; (iii) fraud, embezzlement or other dishonesty with respect to the Company and any of its Affiliates,
taken as a whole, which, in the case of such other dishonesty, causes or could reasonably be expected to cause material harm to the Company and any of its Affiliates, taken as a whole; or
(iv) your conviction of a felony. 

        (b)   The
Company may terminate your employment at any time other than for Cause upon notice to you. 

        (c)   You
may terminate your employment for "Good Reason" upon notice to the Company setting forth in reasonable detail the nature of the Good Reason. The following shall
constitute Good Reason for termination by you: (i) material diminution in the nature or scope of your responsibilities, duties or authority, provided that neither (x) the Company's
failure to continue your appointment or election as a director or officer of any of its Affiliates nor (y) any diminution in the nature or scope of your responsibilities, duties or authority
that is reasonably related to a diminution of the business of the Company or any of its Affiliates, other than any such diminution resulting from the sale or transfer of any or all of the assets of
the Company or any of its Affiliates, shall constitute "Good Reason"; (ii) a reduction in your base salary other than one temporary reduction of not more than 120 days and not in excess
of 20% of your base salary in connection with and in proportion to a general reduction of the base salaries of the Company's executive officers; (iii)—failure of the Company to provide you
the salary or benefits in accordance with Section 2 hereof after thirty (30) days' notice during which the Company does not cure such failure or (iv) relocation of your office
more than thirty-five (35) miles from the location of the Company's principal offices as of the Effective Date. 

        (d)   You
may terminate your employment with the Company other than for Good Reason at any time upon one month's notice to the Company. 

        (e)   This
Agreement shall automatically terminate in the event of your death during employment. The Company may terminate your employment, upon notice to you, in the event
you become disabled during employment and, as a result, are unable to continue to perform substantially all of your duties and responsibilities under this Agreement for one-hundred and
twenty (120) days during any period of three hundred and sixty-five (365) consecutive calendar days. If any question shall arise as to whether you are disabled to the extent
that you are unable to perform substantially all of your duties and responsibilities for the Company and its Affiliates, you shall, at the Company's request and expense, submit to a medical
examination by a physician selected by the Company to whom you or your guardian, if any, has no reasonable objection to determine whether you are so disabled and such determination shall for the
purposes of this Agreement be conclusive of the issue. If such a question arises and you fail to submit to the requested medical examination, the Company's determination of the issue shall be binding
on you. 

        (f)    If,
eighteen months after the Effective Date, your duties as a "venture partner" with Polaris IV (as described in Section 1(b) hereof) are preventing you from
fulfilling your commitment to the Company as determined by a majority of the Board, you will either resign the "venture partner" position with Polaris or you agree to immediately and voluntarily
resign your position with the Company. 

        5.    Severance Payments and Other Matters Related to Termination.    

        (a)    Termination pursuant to Section 4(b), 4(c), or 4(f).    Except as provided in Section 5(c) below, 

        (i)    in
the event of termination of your employment during the two-year period following the Effective Date by the Company other than for Cause pursuant to
Section 4(b) of this Agreement, or in the event of termination of your employment during the two-year period 

3

 

following
the Effective Date by you for Good Reason pursuant to Section 4(c) of this Agreement, fifty percent (50%) of any unvested Restricted Shares shall vest as of the date of termination
(notwithstanding anything to the contrary in Section 2(d) of this Agreement) and the Company will continue to pay you your base salary, at the rate in effect on the date of termination, for the
period of six (6) months from the date of termination; or 

        (ii)   in
the event of termination of your employment after the two-year period following the Effective Date (or the filing by the Company of a Registration
Statement on Form S-1, if earlier) by the Company other than for Cause pursuant to Section 4(b) of this Agreement, or in the event of termination of your employment after the
two-year period following the Effective Date (or the filing by the Company of a Registration Statement on Form S-1, if earlier) by you for Good Reason pursuant to
Section 4(c) of this Agreement, one hundred percent (100%) of any unvested Restricted Shares shall vest as of the date of termination (notwithstanding anything to the contrary in
Section 2(d) of this Agreement) and the Company will
continue to pay you your base salary, at the rate in effect on the date of termination, for the period of one (1) year from the date of termination in lieu of any payment pursuant to
Section 5(a)(i); 

        (iii)  in
the event of your termination of employment as a result of your death or disability at any time, fifty percent (50%) of the then unvested Restricted Shares will
vest as of the date of termination, which in the case of death shall be the date of death (notwithstanding anything to the contrary in Section 2(d) of this Agreement), and to the extent the
Company's benefits do not include disability insurance benefits that will continue your base salary at 100% of the amount of such base salary for the period of one year from the date of termination,
the Company shall pay such amount at the time that your base salary would be otherwise paid as shall equal the amount by which 100% of your base salary exceeds the disability insurance benefits, if
any, actually paid to you; or 

        (iv)  in
the event of your resignation as a result of your "venture partner" status pursuant to Section 4(f) of this Agreement, the Company will continue to pay you
your base salary, at the rate in effect on the date of termination, for the period of three (3) months from the date of termination. 

If
you are participating in the Company's group health plan and/or dental plan at the time your employment terminates and exercise your right to continue participation in those plans under the federal
law known as COBRA, or any successor law, the Company will pay or, at its option, reimburse you, for the full premium cost of that participation for twelve (12) months following the date on
which your employment with the Company terminates or, if earlier, until the date you become eligible to enroll in the health (or, if applicable, dental) plan of a new employer. The Company will also
pay you on the date of termination any base salary earned but not paid through the date of termination and pay for any vacation time accrued but not used to that date. In addition, the Company will
pay you any bonus which has been awarded to you, but not yet paid on the date of termination of your employment. Any obligation of the Company to provide you severance payments or other benefits under
this Section 5(a) is conditioned on your signing an effective release of claims in the form provided by the Company (the "Employee Release") following the termination of your employment, which
release shall not apply to (i) claims for indemnification in your capacity as an officer or director of the Company under the Company's Certificate of Incorporation, By-laws or
agreement, if any, providing for director or officer indemnification, (ii) rights to receive insurance payments under any policy maintained by the Company and (ii) rights to receive
retirement benefits that are accrued and fully vested at the time of your termination. All severance payments will be in the form of salary continuation, payable in accordance with the normal payroll
practices of the Company, and will begin at the Company's next regular payroll period following the effective date of the Employee Release, but shall be retroactive to the date of termination. You
agree to provide the Company prompt notice of 

4

 

your
eligibility to participate in the health plan and, if applicable, dental plan of any employer. You further agree to repay any overpayment of health benefit premiums made by the Company hereunder. 

        (b)    Termination other than pursuant to Section 4(b), 4(c) or 4(f).    In the event of any termination of
your employment, other than a termination by the Company other than for Cause pursuant to Section 4(b) of this Agreement, a termination by you for Good Reason pursuant to Section 4(c) of
this Agreement, a termination as a result of your death or disability pursuant to Section 4(d) or a termination due to "venture partner" status pursuant to Section 4(f) of this
Agreement, the Company shall have the right to repurchase any unvested Restricted Shares for $.001 per share, and the Company will pay you any base salary earned but not paid through the date of
termination and pay for any vacation time accrued but not used to that date. The Company shall have no other obligation to you under this Agreement. 

        (c)    Upon a Change of Control.    

        (i)    If
a Change of Control (as defined in Section 6 hereof) occurs (X) all of your remaining unvested Restricted Shares shall fully vest, effective upon the
consummation of any such Change of Control, and (Y) if, within one year following such Change of Control or otherwise in connection with such Change of Control, the Company or any successor
thereto terminates your employment other than for Cause, or you terminate your employment for Good Reason, then, in lieu of any payments to you or on your behalf under Section 5(a) hereof, the
Company shall pay to you, within thirty (30) days of such termination, a lump sum payment equal to your then-current annual base salary, and, 

        (ii)   Unless
the Company has obtained a vote of the stockholders of the Company meeting the requirements of Section 280G of the Internal Revenue Cord of 1986, as
amended ("Section 280G"), then, notwithstanding the foregoing, the payments and benefits to which you would be entitled hereunder as a result of a Change of Control may be reduced with your
prior written consent to the maximum amount for which the Company will not be limited in its deduction pursuant to Section 280G of the Internal Revenue Code of 1986, as amended, or any
successor provision. Any such reduction shall be applied to the amounts due under Section 6(c)(i) as you may reasonably determine or, if you fail to do so within thirty (30) days
following notice from the Company, as determined by the Company. 

        (d)   Except
for any right you may have under applicable law to continue participation in the Company's group health and dental plans under COBRA, or any successor law,
benefits shall terminate in accordance with the terms of the applicable benefit plans based on the date of termination of your employment, without regard to any continuation of base salary or other
payment to you following termination. 

        (e)   Provisions
of this Agreement shall survive any termination if so provided in this Agreement or if necessary or desirable to accomplish the purposes of other surviving
provisions, including without limitation your obligations under Section 3 of this Agreement and under the Confidentiality, Non-Competition and Proprietary Information Agreement. The
obligation of the Company to make payments to you or on your behalf under Section 5 of this Agreement is expressly conditioned upon your continued full performance of your obligations under
Section 3 hereof, under the Confidentiality, Non-Competition and Proprietary Information Agreement to be executed herewith, and under any subsequent agreement between you and the
Company or any of its Affiliates relating to confidentiality, non-competition, proprietary information or the like. 

        6.    Definitions.    For purposes of this agreement, the following definitions apply: 

        "Affiliates"
means all persons and entities directly or indirectly controlling, controlled by or under common control with the Company, where control may be by management authority,
equity interest or otherwise. 

5

 

        "Change
of Control" shall mean (i) the acquisition of beneficial ownership (as defined in Rule 13d-3 under the Exchange Act) directly or indirectly by any
"person" (as such term is used in Sections 13(d) and 14(d) of the Exchange Act), of securities of the Company representing a majority or more of the combined voting power of the Company's then
outstanding securities, other than an acquisition of securities for investment purposes pursuant to a bona fide financing of the Company; (ii) a merger or consolidation of the Company with any
other corporation in which the holders of the voting securities of the Company prior to the merger or consolidation do not own more than 50% of the total voting securities of the surviving
corporation; or (iii) the sale or disposition by the Company of all or substantially all of the Company's assets other than a sale or disposition of assets to an Affiliate of the Company or a
holder of securities of the Company. 

        "Person"
means an individual, a corporation, an association, a partnership, an estate, a trust and any other entity or organization, other than the Company or any of its Affiliates. 

        7.    Conflicting Agreements.    You hereby represent and warrant that your signing of this
Agreement and the performance of your obligations under it will not breach or be in conflict with any other agreement to which you are a party or are bound and that you are not now subject to any
covenants against competition or similar covenants or any court order that could affect the performance of your obligations under this Agreement. You agree that you will not disclose to or use on
behalf of the Company any proprietary information of a third party without that party's consent. 

        8.    Withholding.    All payments made by the Company under this Agreement shall be reduced
by any tax or other amounts required to be withheld by the Company under applicable law. 

        9.    Assignment.    Neither you nor the Company may make any assignment of this Agreement or
any interest in it, by operation of law or otherwise, without the prior written consent of the other; provided, however, that the Company may assign its rights and obligations under this Agreement
without your consent to one of its Affiliates or to any Person with whom the Company shall hereafter affect a reorganization, consolidate with, or merge into or to whom it transfers all or
substantially all of its
properties or assets. This Agreement shall inure to the benefit of and be binding upon you and the Company, and each of our respective successors, executors, administrators, heirs and permitted
assigns. 

        10.    Severability.    If any portion or provision of this Agreement shall to any extent be
declared illegal or unenforceable by a court of competent jurisdiction, then the remainder of this Agreement, or the application of such portion or provision in circumstances other than those as to
which it is so declared illegal or unenforceable, shall not be affected thereby, and each portion and provision of this Agreement shall be valid and enforceable to the fullest extent permitted by law. 

        11.    Miscellaneous.    This Agreement, together with the Stock Restriction Agreement and the
Confidentiality, Non-Competition and Proprietary Information Agreement, sets forth the entire agreement between you and the Company and replaces all prior communications, agreements and
understandings, written or oral, with respect to the terms and conditions of your employment. This Agreement may not be modified or amended, and no breach shall be deemed to be waived, unless agreed
to in writing by you and an expressly authorized representative of the Board. The headings and captions in this Agreement are for convenience only and in no way define or describe the scope or content
of any provision of this Agreement. This Agreement may be executed in two or more counterparts, each of which shall be an original and all of which together shall constitute one and the same
instrument. This is a Massachusetts contract and shall be governed and construed in accordance with the laws of the Commonwealth of Massachusetts, without regard to the
conflict-of-laws principles thereof. 

        12.    Legal Fees.    The Company will pay your legal fees in the amount of $6,000 in
connection with the negotiation of your employment arrangement with the Company. 

6

 

        12.    Notices.    Any notices provided for in this Agreement shall be in writing and shall be
effective when delivered in person, consigned to a reputable national courier service for overnight delivery or deposited in the United States mail, postage prepaid, and addressed to you at your last
known address on the books of the Company or, in the case of the Company, to it by notice to the Chairman of the Board of Directors, c/o Sirtris Pharmaceuticals, Inc. at its principal place of
business, or to such other address(es) as either party may specify by notice to the other actually received. 

        If
the foregoing is acceptable to you, please sign and date this letter in the spaces provided. At the time you sign and return it, this letter will take effect as a binding agreement
between you and the Company on the basis set forth above. The enclosed copy is for your records. 

Sincerely,

Sirtris Pharmaceuticals, Inc. 

	By:	/s/  STEPHEN HOFFMAN      
 Stephen J. Hoffman

Director	 
	

Accepted and Agreed:
	

Signature:
	

 	

/s/  CHRISTOPH WESTPHAL      
 Christoph Westphal	

 

Date:
February 14, 2005 

7

 
AMENDMENT NO. 1 TO

EMPLOYMENT AGREEMENT  

        This Amendment No. 1 to Employment Agreement (the "Amendment"), dated as of August 30, 2006 amends the Employment Agreement dated as of
February 14, 2005 among Sirtris Pharmaceuticals, Inc. (the "Company") and Christoph Westphal, M.D., Ph.D. ("Employee"), (prior to giving effect to this amendment, the "Employment
Agreement" and, after giving effect to this amendment, the "Amended
Employment Agreement"). Capitalized terms used but not defined herein shall have the meanings set forth in the Voting Agreement. 

RECITALS: 

        WHEREAS,
the Company and Employee wish to amend the terms of the Employment Agreement. 

        NOW
THEREFORE, in consideration of the mutual agreements set forth herein, the Company and the undersigned Investors agree as follows: 

        1.     Section 1(b)
of the Employment Agreement is hereby amended and replaced in its entirety the first paragraph thereof with the following: 

"(b)
Activities Outside the Company. You may have four outside commitments with companies other than the Company (including service as a member of the
board of directors or as an advisor of such other companies), with such outside commitments to be subject to the approval of the Company's Nominating and Corporate Governance Committee (the
"Committee"). The Committee may also, in its discretion, increase the number of outside commitments you may have. You will notify the Committee of any change in your outside commitments. You will, as
a general rule, not attend board meetings of any other company other than the Company and those other companies for which you serve as a director." 

        2.     Section 4(a)
of the Employment Agreement is hereby amended by deleting, in clause (i) of the second sentence, the word "Affiliates" and replacing it with
the words "direct or indirect subsidiaries". 

        3.     General. The Employment Agreement and this Amendment constitute the entire understanding of the parties with respect to
the subject matter hereof and thereof and supersede all prior and current understandings and agreements, whether written or oral. This Amendment may be executed in any number of counterparts, which
together shall constitute one instrument, and shall bind and inure to the benefit of the parties and their respective successors and assigns. The Amended Employment Agreement shall be governed by and
construed in accordance with the laws (other than the conflict of law rules) of The Commonwealth of Massachusetts. The Amended Employment Agreement shall be binding on all Investors, whether or not
party hereto. 

8

 

        IN
WITNESS WHEREOF, this Amendment has been executed by the parties hereto as of the day and year first above written. 

	SIRTRIS PHARMACEUTICALS, INC.	 
	
By:	

/s/  GAREN BOHLIN      
	

 
	Name: Garen Bohlin

Title: Chief Operating Officer	 
	
EMPLOYEE	

 
	
/s/  CHRISTOPH WESTPHAL      
 Christoph Westphal, M.D., Ph.D.

	

 

9

 
Amendment to Westphal Employment Agreement  

 AMENDMENT NO. 2 TO

EMPLOYMENT AGREEMENT  

        This Amendment No. 2 to Employment Agreement (the "Amendment"), dated as of February 14, 2007 amends the Employment Agreement dated as of
February 14, 2005 among Sirtris Pharmaceuticals, Inc.
(the "Company") and Christoph Westphal, M.D., Ph.D. ("Employee"), as amended by Amendment No. 1 to Employment Agreement (prior to giving effect to this amendment, the "Employment Agreement"
and, after giving effect to this amendment, the "Amended Employment Agreement"). Capitalized terms used but not defined herein shall have the meanings set forth in the Employment Agreement. 

RECITALS: 

        WHEREAS,
the Company and Employee wish to amend the terms of the Employment Agreement. 

        NOW
THEREFORE, in consideration of the mutual agreements set forth herein, the Company and the Employee agree as follows: 

        1.     The
second sentence of Section 4(c) of the Employment Agreement is hereby amended and replaced in its entirety the first paragraph thereof with the following: 

The
following shall constitute Good Reason for termination by you: (i) material diminution in the nature or scope of your responsibilities, duties or authority, provided that in the absence of
a Change of Control neither (x) the Company's failure to continue your appointment or election as a director or officer of any of its Affiliates nor (y) any diminution in the nature or
scope of your responsibilities, duties or authority that is reasonably related to a diminution of the business of the Company or any of its Affiliates shall constitute "Good Reason"; (ii) any
diminution in position, base salary or bonus or in the nature or scope of your responsibilities, duties or authority in anticipation of or after a Change of Control, it being specifically acknowledged
that your failure to continue as CEO of the Company and to serve on the Board of Directors of the Company (and any parent company directly or indirectly owning or controlling 50% or more of the
securities of the Company after the Change of Control) shall constitute "Good Reason;" (iii) a reduction in your base salary other than one temporary reduction of not more than 120 days
and not in excess of 20% of your base salary in connection with and in proportion to a general reduction of the base salaries of the Company's executive officers; (iv) failure of the Company to
provide you the salary or benefits in accordance with Section 2 hereof after thirty (30) days' notice during which the Company does not cure such failure or (v) relocation of your
office more than thirty-five (35) miles from the location of the Company's principal offices as of the Effective Date. 

        2.     General.
The Employment Agreement and this Amendment constitute the entire understanding of the parties with respect to the subject matter hereof and thereof and
supersede all prior and current understandings and agreements, whether written or oral. This Amendment may be executed in any number of counterparts, which together shall constitute one instrument,
and shall bind and inure to the benefit of the parties and their respective successors and assigns. The Amended Employment Agreement shall be governed by and construed in accordance with the laws
(other than the conflict of law rules) of The Commonwealth of Massachusetts. The Amended Employment Agreement shall be binding on all Investors, whether or not party hereto. 

10

 

        IN
WITNESS WHEREOF, this Amendment has been executed by the parties hereto as of the day and year first above written. 

	SIRTRIS PHARMACEUTICALS, INC.	 
	
By:	

/s/  GAREN BOHLIN      
	

 
	Name: Garen Bohlin

Title: Chief Operating Officer	 
	
EMPLOYEE	

 
	

/s/  CHRISTOPH WESTPHAL      
 Christoph Westphal, M.D., Ph.D.

	

 

11

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Exhibit 10.12    
    

SIRTRIS
PHARMACEUTICALS, INC.

790 MEMORIAL DRIVE, SUITE 104

CAMBRIDGE, MA 02139 

December 17,
2005 

Garen
Bohlin

456 Belmont Street #23

Watertown, MA 02472 

Dear
Garen: 

        This
letter agreement ("Agreement") will confirm our offer to you of employment with Sirtris Pharmaceuticals, Inc. (the "Company"), under the terms and conditions that follow: 

        1.    Position and Duties.    

        (a)    The Company.    Effective January 1, 2006 (the "Effective Date"), you will be
employed by the Company, on a full-time basis, as its Chief Operating Officer, reporting to the Chief Executive Officer of the Company. You agree to perform the duties of your position and
such other duties as reasonably may be assigned to you from time to time. You also agree that while employed by the Company, you will devote one hundred percent (100%) of your business time and your
reasonable commercial efforts, business judgment, skill and knowledge exclusively to the advancement of the business and interests of the Company and to the discharge of your duties and
responsibilities for it. You may, however, with the approval of the Chief Executive Officer of the Company, continue to serve
as a director of the three corporations for which you currently serve as a director whose businesses are not competitive with the Company. Prior to the six-month anniversary of the
Effective Date you will resign from the board of directors of one of these corporations and from that point forward you may, with the approval of the Chief Executive Officer of the Company, serve as a
director of up to two corporations whose businesses are not competitive with the Company. 

        2.    Compensation and Benefits.    During your employment, as compensation for all services
performed by you for the Company and subject to your performance of your duties and responsibilities for the Company, pursuant to this Agreement or otherwise, the Company will provide you the
following pay and benefits: 

        (a)    Base Salary.    The Company will pay you a base salary at the rate of Two Hundred
Ninety Thousand Dollars ($290,000) per year. Such amount shall be payable in accordance with the regular payroll practices of the Company for its executives, as in effect from time to time, and
subject to increase from time to time by the Board in its discretion. 

        (b)    Bonus Compensation.    During your employment, you may be considered annually for a
bonus in addition to your base salary. Bonus compensation in any year, if any, will be determined by the Board based on your performance and that of the Company, in accordance with a general executive
bonus program to be established and agreed upon by you and the Board's Compensation Committee. 

        (c)    Stock Options.    Subject to approval by the Board of Directors, at the next regular
meeting of the Board following the Effective Date you will be awarded an option to purchase 1,500,000 shares of the common stock of the Company at the then fair market value of the Company's common
stock (the "Employment Option"). The Employment Option will vest as follows: twenty-five percent (25%) of the shares subject to the Employment Option shall vest on the one-year
anniversary of the Effective Date, provided you are employed by the Company on that date, and the remainder of the shares subject to the Employment Option will vest ratably, on a quarterly basis, on
the last date of each of the next twelve (12) quarters after the Effective Date, provided that you remain in the Company's employ at each such vesting date. While the 

 

determination
of the fair market value of the Company's common stock is at the discretion of the Board of Directors, incentive stock options of the company are currently being priced at $.08 per
share, which the Board of Directors has determined to be the current fair market value of the Company's common stock at its most recent meeting. In addition to the terms set forth above, the
Employment Option will be subject to the Company's standard terms of stock options and will be documented in one or more stock option agreements that you will receive promptly following the date of
issuance of the options. The Board may from time to time grant to you additional options in its discretion. 

        (d)    Participation in Employee Benefit Plans.    You will also be eligible to participate in
all employee benefit plans of the Company (or such greater benefits as are generally made available to the Company's executive officers), except to the extent such plans are duplicative of benefits
otherwise provided you under this Agreement (e.g., severance pay) or under any other agreement. In addition you will be eligible to participate in the
Sirtris 401 (k) Plan. All of the Company benefit plans will be subject to the plan terms and the applicable Company policies and are subject to modification at the discretion of the Board. 

        (e)    Vacations.    You will accrue three weeks paid vacation per year (or such greater
amount as is generally made available to the Company's executive officers) in accordance with the Company's policies from time to time in effect and receive paid holidays (currently 11 per year) in
accordance with the Company holiday schedule. Vacation may be taken at such times and intervals as you shall determine, subject to the business needs of the Company, and otherwise shall be subject to
the policies of the Company, as in effect from time to time. 

        (f)    Business Expenses.    The Company will pay or reimburse you for all reasonable business
expenses incurred or paid by you in the performance of your duties and responsibilities for the Company, subject to any maximum annual limit and other restrictions on such expenses set by the Company
and to such reasonable substantiation and documentation as it may specify from time to time. 

        3.    Confidential Information, Non-Competition and Proprietary
Information.    Your employment with the Company is conditioned upon and subject to your agreement to the Company's Confidentiality, Non-Competition and
Proprietary Information Agreement, to be executed by you simultaneously herewith. It is understood and agreed that breach by you of the Confidential Information, Non-Competition and
Proprietary Information Agreement shall constitute a material breach of this Agreement. 

        4.    Termination of Employment.    Your employment under this Agreement shall continue until
terminated pursuant to this Section 4. 

        (a)   The
Company may terminate your employment for "Cause" upon written notice to you setting forth in reasonable detail the nature of the Cause. The following, as determined
by the Board in its
reasonable judgment, shall constitute Cause for termination: (i) your willful failure to perform, or gross negligence in the performance of, your material duties and responsibilities to the
Company and its Affiliates which is not remedied within thirty (30) days of written notice thereof; (ii) material breach by you of any material provision of this Agreement or any other
agreement with the Company or any of its Affiliates which is not remedied within thirty (30) days of written notice thereof; (iii) fraud, embezzlement or other dishonesty with respect to
the Company and any of its Affiliates, taken as a whole, which, in the case of such other dishonesty, causes or could reasonably be expected to cause material harm to the Company and any of its
Affiliates, taken as a whole; or (iv) your conviction of a felony. 

        (b)   The
Company may terminate your employment at any time other than for Cause upon one month's written notice to you. 

2

 

        (c)   You
may terminate your employment for "Good Reason" upon written notice to the Company setting forth in reasonable detail the nature of the Good Reason. The following
shall constitute Good Reason for termination by you: (i) material diminution in the nature or scope of your responsibilities, duties or authority, provided that none of the following shall
constitute "Good Reason": (x) the Company's failure to continue your appointment or election as a director or officer of any of its Affiliates, or (y) any diminution in the nature or
scope of your responsibilities, duties or authority that is reasonably related to a diminution of the business of the Company or any of its Affiliates, other than any such diminution resulting from
the sale or transfer of any or all of the assets of the Company or any of its Affiliates; (ii) a reduction in your base salary other than one temporary reduction of not more than
120 days and not in excess of 20% of your base salary in connection with and in proportion to a general reduction of the base salaries of the Company's executive officers; (iii) failure
of the Company to provide you the salary or benefits in accordance with Section 2 hereof after thirty (30) days' notice during which the Company does not cure such failure; or
(iv) relocation of your office more than thirty-five (35) miles from the location of the Company's principal offices as of the Effective Date. 

        (d)   You
may terminate your employment with the Company other than for Good Reason at any time upon one month's notice to the Company. 

        (e)   This
Agreement shall automatically terminate in the event of your death during employment. The Company may terminate your employment, upon notice to you, in the event
you become disabled during employment and, as a result, are unable to continue to perform substantially all of your material duties and responsibilities under this Agreement for
one-hundred and fifty (150) days during any period of three hundred and sixty-five (365) consecutive calendar days. If any question shall arise as to whether you
are disabled to the extent that you are unable to perform substantially all of your material duties and responsibilities for the Company and its Affiliates, you shall, at the Company's request and
expense, submit to a medical examination by a physician selected by the Company to whom you or your guardian, if any, has no reasonable objection to determine
whether you are so disabled and such determination shall for the purposes of this Agreement be conclusive of the issue. If such a question arises and you fail to submit to the requested medical
examination, the Company's determination of the issue shall be binding on you. 

        5.    Severance Payments and Other Matters Related to Termination.    

        (a)    Termination pursuant to Section 4(b), 4(c) or 4(e).    Except as provided in Section 5(c) below, 

        (i)    in
the event of termination of your employment following the Effective Date by the Company other than for Cause pursuant to Section 4(a) of this Agreement, or in
the event of termination of your employment following the Effective Date by you for Good Reason pursuant to Section 4(c) of this Agreement, the Employment Option shall vest as of the date of
termination (notwithstanding anything to the contrary in Section 2(c) of this Agreement) with respect to an additional one year of vesting and the Company will (i) continue to pay you
your base salary, at the rate in effect on the date of termination, for the period of nine (9) months from the date of termination and (ii) pay a pro-rata portion (for the
period from January 1 of the year of termination through the date of termination) of the cash bonus paid to you in the previous year, if any; or 

        (ii)   in
the event of your termination of employment as a result of your death or disability at any time pursuant to Section 4(e) of this Agreement, the Employment
Option shall vest as of the date of termination, which in the case of death shall be the date of death (notwithstanding anything to the contrary in Section 2(c) of this Agreement), with respect
to an additional one year of vesting, and, to the extent the Company's benefits do not include disability insurance benefits that will (i) continue your base salary at 100% of the amount of 

3

 

such
base salary for the period of nine (9) months from the date of termination and (ii) pay a pro-rata portion (for the period from January 1 of the year of
termination through the date of termination) of the cash bonus paid to you in the previous year, if any, the Company shall pay such amount at the time that your base salary would be otherwise paid
during such nine (9) months from the date of termination as shall equal the amount by which (i) 100% of your base salary plus (ii) the pro rata portion of the cash bonus paid to
you in the year prior to such termination, if any, exceeds the disability insurance benefits, if any, actually paid to you. 

If
you are participating in the Company's group health plan and/or dental plan at the time your employment terminates (whether such termination is as described in (i) or (ii) above), and
you exercise your right to continue participation in those plans under the federal law known as COBRA, or any successor law, the Company will pay or, at its option, reimburse you, for the full premium
cost of that participation for nine (9) months following the date on which your employment with the Company terminates or, if earlier, until the date you become eligible to enroll in the health
(or, if applicable, dental) plan of a new employer. The Company will also pay you on the date of termination any base salary earned but not paid through the date of termination and pay for any
vacation time accrued but
not used to that date. In addition, the Company will pay you any bonus which has been awarded to you, but not yet paid on the date of termination of your employment. Any obligation of the Company to
provide you severance payments or other benefits under this Section 5(a) is conditioned on your signing an effective release of claims in the form provided by the Company (the "Employee
Release") following the termination of your employment, which release shall not apply to (i) claims for indemnification in your capacity as an officer or director of the Company under the
Company's Certificate of Incorporation, By-laws or agreement, if any, providing for director or officer indemnification, (ii) rights to receive insurance payments under any policy
maintained by the Company and (iii) rights to receive retirement benefits that are accrued and fully vested at the time of your termination. All severance payments will be in the form of salary
continuation, payable in accordance with the normal payroll practices of the Company, and will begin at the Company's next regular payroll period following the effective date of the Employee Release,
but shall be retroactive to the date of termination. You agree to provide the Company prompt notice of your eligibility to participate in the health plan and, if applicable, dental plan of any
employer. You further agree to repay any overpayment of health benefit premiums made by the Company hereunder. 

        (b)    Termination other than pursuant to Section 4(b) or 4(c).    In the event of any termination of your
employment, other than a termination by the Company pursuant to Section 4(b) of this Agreement, a termination by you for Good Reason pursuant to Section 4(c) of this Agreement, or a
termination as a result of your death or disability pursuant to Section 4(e) of this Agreement, the Company will pay you any base salary earned but not paid through the date of termination and
pay for any vacation time accrued but not used to that date. In addition, the Company will pay you any bonus which has been awarded to you, but not yet paid on the date of termination of your
employment. The Company shall have no other obligation to you under this Agreement. 

        (c)    Upon a Change of Control.    

        (i)    If
a Change of Control (as defined in Section 6 hereof) occurs (X) of your then remaining unvested options, those which are scheduled to vest in the twelve
(12) months following such Change of Control shall vest, effective upon the consummation of such Change of Control, and (Y) if, within one year following such Change of Control or
otherwise in connection with such Change of Control, the Company or any successor thereto terminates your employment other than for Cause, or you terminate your employment for Good Reason, then, in
lieu of any payments to you or on your behalf under Section 5(a) hereof, (i) the Company shall pay to you, within thirty (30) days of such termination, (x) a lump sum
payment equal to twelve (12) months of your then-current base salary and (y) a pro-rata portion (for the period from January 1 of the year of termination
through the date of 

4

 

termination)
of the cash bonus paid to you in the previous year, if any, (ii) the Company will also pay you on the date of termination any base salary earned but not paid through the date of
termination and pay for any vacation time accrued but not used to that date, (iii) of your then remaining unvested options, a number equal to (x) 50% of your unvested options immediately
prior to the Change of Control minus (y) the number options vesting pursuant to clause (X) above, shall vest effective upon the date of
such termination, and (iv) if you are participating in the Company's group health plan and/or dental plan at the time your employment terminates, and you exercise your right to continue
participation in those plans under the federal law known as COBRA, or any successor law, the Company will pay or, at its option, reimburse you, for the full premium cost of that participation for
twelve (12) months following the date on which your employment with the Company terminates or, if earlier, until the date you become eligible to enroll in the health (or, if applicable, dental)
plan of a new employer. In addition, the Company will pay you any bonus which has been awarded to you, but not yet paid on the date of termination of your employment. 

        (ii)   If
any payment or benefit you would receive under this Agreement, when combined with any other payment or benefit you receive pursuant to the termination of your
employment with the Company ("Payment") would (i) constitute a "parachute payment" within the meaning of Section 280G of the Internal Revenue Code of 1986, as amended (the "Code"), and
(ii) but for this sentence, be subject to the excise tax imposed by Section 4999 of the Code (the "Excise Tax"), then such Payment shall be either (x) the full amount of such
Payment or (y) such less amount (with cash payments being reduced before stock option compensation) as would result in no portion of the Payment being subject to the Excise Tax, whichever of
the foregoing amounts, taking into account the applicable federal state and local employments taxes, income taxes, and the Excise Tax results in your receipt, on an after-tax basis, of the
greater amount of the Payment notwithstanding that all or some portion of the Payment may be subject to the Excise Tax. 

        (d)   Except
for any right you may have under applicable law to continue participation in the Company's group health and dental plans under COBRA, or any successor law,
benefits shall terminate in accordance with the terms of the applicable benefit plans based on the date of termination of your employment, without regard to any continuation of base salary or other
payment to you following termination. 

        (e)   Provisions
of this Agreement shall survive any termination if so provided in this Agreement or if necessary or desirable to accomplish the purposes of other surviving
provisions, including without limitation your obligations under Section 3 of this Agreement and under the Confidentiality, Non-Competition and Proprietary Information Agreement. The
obligation of the Company to make payments to you or on your behalf under Section 5 of this Agreement is expressly conditioned upon your continued full performance of your obligations under
Section 3 hereof, under the Confidentiality, Non-Competition and Proprietary Information Agreement to be executed herewith, and under any subsequent agreement between you and the
Company or any of its Affiliates relating to confidentiality, non-competition, proprietary information or the like. 

        6.    Definitions.    For purposes of this agreement, the following definitions apply: 

        "Affiliates"
means all persons and entities directly or indirectly controlling, controlled by or under common control with the Company, where control may be by management authority,
equity interest or otherwise. 

        "Change
of Control" shall mean (i) the acquisition of beneficial ownership (as defined in Rule 13d-3 under the Exchange Act) directly or indirectly by any
"person" (as such term is used in Sections 13(d) and 14(d) of the Exchange Act), of securities of the Company representing a majority or more of the combined voting power of the Company's then
outstanding securities, other than an 

5

 

acquisition
of securities for investment purposes pursuant to a bona fide financing of the Company; (ii) a merger or consolidation of the Company with any other corporation in which the holders
of the voting securities of the Company prior to the merger or consolidation do not own more than 50% of the total voting securities of the surviving corporation; or (iii) the sale or
disposition by the Company of all or substantially all of the Company's assets other than a sale or disposition of assets to an Affiliate of the Company or a holder of securities of the Company. 

        "Person"
means an individual, a corporation, an association, a partnership, an estate, a trust and any other entity or organization, other than the Company or any of its Affiliates. 

        7.    Conflicting Agreements.    You hereby represent and warrant that your signing of this
Agreement and the performance of your obligations under it will not breach or be in conflict with any other agreement to which you are a party or are bound and that you are not now subject to any
covenants against competition or similar covenants or any court order that could affect the performance of your obligations under this Agreement. You agree that you will not disclose to or use on
behalf of the Company any proprietary information of a third party without that party's consent. 

        8.    Withholding.    All payments made by the Company under this Agreement shall be reduced
by any tax or other amounts required to be withheld by the Company under applicable law. 

        9.    Assignment.    Neither you nor the Company may make any assignment of this Agreement or
any interest in it, by operation of law or otherwise, without the prior written consent of the other; provided, however, that the Company may assign its rights and obligations under this Agreement
without your consent to one of its Affiliates or to any Person with whom the Company shall hereafter affect a reorganization, consolidate with, or merge into or to whom it transfers all or
substantially all of its properties or assets. This Agreement shall inure to the benefit of and be binding upon you and the Company, and each of our respective successors, executors, administrators,
heirs and permitted assigns. 

        10.    Severability.    If any portion or provision of this Agreement shall to any extent be
declared illegal or unenforceable by a court of competent jurisdiction, then the remainder of this Agreement, or the application of such portion or provision in circumstances other than those as to
which it is so declared illegal or unenforceable, shall not be affected thereby, and each portion and provision of this Agreement shall be valid and enforceable to the fullest extent permitted by law. 

        11.    Miscellaneous.    This Agreement, together with the Confidentiality,
Non-Competition and Proprietary Information Agreement, sets forth the entire agreement between you and the Company and replaces all prior communications, agreements and understandings,
written or oral, with respect to the terms and conditions of your employment. This Agreement may not be modified or amended, and no breach shall be deemed to be waived, unless agreed to in writing by
you and an expressly authorized representative of the Board. The headings and captions in this Agreement are for convenience only and in no way define or describe the scope or content of any provision
of this Agreement. This Agreement may be executed in two or more counterparts, each of which shall be an original and all of which together shall constitute one and the same instrument. This is a
Massachusetts contract and shall be governed and construed in accordance with the laws of the Commonwealth of Massachusetts, without regard to the conflict-of-laws principles
thereof. 

        12.    Notices.    Any notices provided for in this Agreement shall be in writing and shall be
effective when delivered in person, consigned to a reputable national courier service for overnight delivery or deposited in the United States mail, postage prepaid, and addressed to you at your last
known address on the books of the Company or, in the case of the Company, to it by notice to the Chairman of the Board of Directors, c/o Sirtris Pharmaceuticals, Inc. at its principal place of
business, or to such other address(es) as either party may specify by notice to the other actually received. 

[Remainder
of page intentionally left blank.] 

6

 

        If
the foregoing is acceptable to you, please sign and date this letter in the spaces provided. At the time you sign and return it, this letter will take effect as a binding agreement
between you and the Company on the basis set forth above. The enclosed copy is for your records. 

Sincerely,

Sirtris Pharmaceuticals, Inc. 

	By:	/s/  CHRISTOPH WESTPHAL      
 Christoph Westphal

President and Chief Executive Officer	 
	

Accepted and Agreed:
	

Signature:
	

 	

/s/  GAREN BOHLIN      
 Garen Bohlin	

 

Date:
December 17, 2005 

7

QuickLinks

Exhibit 10.12

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