Document:

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                                   EXHIBIT 4.3

      Placement Agent Warrant Agreement Dated February 13, 2002 Between the
                    Registrant and Sunrise Securities Corp.

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                                 MATRITECH, INC.

                                       AND

                            SUNRISE SECURITIES CORP.

                                -----------------

                        PLACEMENT AGENT WARRANT AGREEMENT

                            Dated: February 13, 2002

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      THIS WARRANT AGREEMENT (this "AGREEMENT") dated February 13, 2002 is made
and entered into by and between Matritech, Inc., a corporation organized under
the laws of the State of Delaware (the "COMPANY"), and Sunrise Securities Corp.
("SUNRISE").

      Subject to the terms and conditions hereof, the Company agrees to issue to
Sunrise, pursuant to the Engagement Letter dated December 20, 2001, by and
between the Company and Sunrise, warrants as hereinafter described (the
"Warrants") exercisable at $2.81 per share to purchase up to 174,425 shares of
Common Stock, 10% of the total number of shares of Common Stock sold in the
offering. As used herein, the terms "Share" or "Shares" shall mean collectively
the Common Stock issuable upon exercise of the Warrants together with any other
securities issuable upon such exercise as provided in Section 8 of this
Agreement. Except, where otherwise specified, the terms of this Agreement shall
apply to all registered holders of the Warrants (together with Sunrise, the
"Warrantholders").

      For the purpose of defining the terms and provisions of the Warrants and
the respective rights and obligations thereunder, the Company and Sunrise, for
value received, hereby agree as follows:

      SECTION 1. TRANSFERABILITY AND FORM OF WARRANTS.

      1.1. REGISTRATION. The Warrants shall be numbered and shall be registered
on the books of the Company when issued, in accordance with Delaware corporate
practice.

      1.2. TRANSFER. The Warrants shall be transferable only on the books of the
Company maintained at its principal office in Newton, Massachusetts, or wherever
its principal office may then be located, upon delivery thereof duly endorsed by
the Warrantholder seeking such transfer or by its duly authorized attorney or
representative, accompanied by proper evidence of succession, assignment or
authority to transfer. Upon any registration of transfer, the Company shall
execute and deliver new Warrants to the person entitled thereto.

      1.3. LIMITATIONS ON TRANSFER OF THE WARRANTS. Subject to the provisions of
Section 11 of this Agreement, the Warrants shall not be sold, assigned,
hypothecated or otherwise transferred, except to: (i) one or more persons, each
of whom on the date of transfer is an officer of Sunrise; (ii) a general
partnership or general partnerships, all the general partners in which are
Sunrise or controlling persons of Sunrise and one or more persons, each of whom
on the date of transfer is an officer of Sunrise; (iii) a successor to Sunrise
by merger or consolidation; or (iv) a purchaser of all or substantially all of
Sunrise's assets. The term "Warrants" shall include any and all warrants
outstanding pursuant to this Agreement, including those evidenced by a
certificate or certificates issued upon division, exchange, substitution or
transfer pursuant to this Agreement.

      1.4. FORM OF WARRANTS. The form of certificate evidencing the Warrants
shall be substantially as set forth in EXHIBIT A attached hereto. Certificates
evidencing the Warrants shall be executed on behalf of the Company by its
Chairman, President or by

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any Vice President, shall be attested to by its Secretary or any Assistant
Secretary, and shall be dated as of the date of execution thereof.

      1.5. LEGEND ON COMMON STOCK. The Warrants, and the Shares have not been
registered under the Securities Act of 1933, as amended (the "ACT"). Each
certificate for Shares shall bear the following legend unless, at the time of
exercise, such Shares are the subject of a currently effective registration
statement under the Act:

      "THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED
      UNDER THE UNITED STATES SECURITIES ACT OF 1933 OR THE SECURITIES LAWS OF
      ANY STATE OF THE UNITED STATES. SUCH SECURITIES MAY NOT BE SOLD, ASSIGNED,
      EXCHANGED, HYPOTHECATED OR OTHERWISE TRANSFERRED IN ANY MANNER EXCEPT IN
      COMPLIANCE WITH SECTION 11 OF THE WARRANT AGREEMENT BY AND BETWEEN THE
      ISSUER AND SUNRISE SECURITIES CORP. DATED FEBRUARY 13, 2002."

      Any certificate issued at any time in exchange or substitution for any
certificate bearing such legend (except a new certificate issued upon completion
of a public distribution pursuant to a registration statement under the Act of
the securities represented thereby) shall also bear the above legend unless, in
the opinion of the Company's counsel, the securities represented thereby need no
longer be subject to such restrictions.

      SECTION 2. EXCHANGE OF WARRANT CERTIFICATE. Any Warrant certificate may be
exchanged for another certificate or certificates entitling a Warrantholder to
purchase a like aggregate number of Shares as the certificate or certificates
surrendered then entitles such Warrantholder to purchase. Any Warrantholder
desiring to exchange a Warrant certificate shall make such request in writing
delivered to the Company, and shall surrender, properly endorsed, the
certificate evidencing the Warrant to be so exchanged. Thereupon, the Company
shall execute and deliver to the person entitled thereto a new Warrant
certificate as so requested.

      SECTION 3. TERM OF WARRANTS; EXERCISE OF WARRANTS

      (a) Subject to the terms of this Agreement, each Warrantholder shall have
the right, at any time during the period commencing at 9:00 a.m., Eastern Time,
on February 13, 2002 (the "COMMENCEMENT DATE") and ending at 5:00 p.m., Eastern
Time, on February 13, 2005 (the "TERMINATION DATE"), to purchase from the
Company up to the number of fully paid and nonassessable Shares which such
Warrantholder may at the time be entitled to purchase pursuant to this
Agreement, upon surrender to the Company at its principal office of the
certificate evidencing the Warrants to be exercised, with the purchase form on
the reverse thereof duly completed and signed, and upon payment to the Company
of the Warrant Price (as defined in and determined in accordance with the
provisions of this Section 3 and Sections 7 and 8 hereof) for the number of
Shares in respect of which such Warrants are then exercised, but in no event for
fewer than 100

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Shares (unless fewer than an aggregate of 100 Shares are then purchasable under
all outstanding Warrants held of record by a Warrantholder). Payment of the
aggregate Warrant Price shall be made in cash or by certified or cashier's
check, in next day funds, or any combination thereof.

            (b) Upon surrender of Warrant certificates and payment of the
Warrant Price, the Company shall issue and cause to be delivered with all
reasonable dispatch to or upon the written order of a Warrantholder, and
(subject to Section 11 hereof) in such name or names as such Warrantholder may
designate, a certificate or certificates for the number of full Shares so
acquired upon the exercise of the Warrant, together with cash, as provided in
Section 9 hereof, in respect of any fractional Shares otherwise issuable upon
such surrender. Such certificate or certificates shall be deemed to have been
issued and any person so designated to be named therein shall be deemed to have
become a holder of record of such Shares as of the date of surrender of the
Warrants being exercised and payment of the Warrant Price notwithstanding that
the certificate or certificates representing such securities shall not actually
have been delivered or that the stock transfer books of the Company shall then
be closed. The Warrants shall be exercisable at the election of a Warrantholder
either in full or from time to time in part and, in the event that a certificate
evidencing Warrants is exercised in respect of fewer than all of the Shares
specified therein at any time prior to the Termination Date, a new certificate
evidencing the remaining portion of the Warrants shall be issued by the Company.

      SECTION 4. PAYMENT OF TAXES. The Company will pay all taxes and fees, if
any (other than any income taxes that may be imposed on the exercise of the
Warrants or on the subsequent sale of the Shares), attributable to the initial
issuance of the Warrants or the issuance of Shares upon exercise of the
Warrants; provided that the Company shall not be required to pay any tax or fee
which may be payable in respect of any secondary transfer of the Warrants or
such Shares.

      SECTION 5. MUTILATED OR MISSING WARRANTS. In case the certificate or
certificates evidencing any Warrants shall be mutilated, lost, stolen or
destroyed, the Company shall, at the request of the affected Warrantholder,
issue and deliver in exchange and substitution for and upon cancellation of the
mutilated certificate or certificates, or in lieu of and substitution for the
certificate or certificates lost, stolen or destroyed, a new Warrant certificate
or certificates of like tenor and representing an equivalent right or interest,
but only upon receipt of evidence satisfactory to the Company of the loss, theft
or destruction of such Warrant and, if requested, at the cost and expense of the
Warrantholder, a bond of indemnity in form and amount satisfactory to the
Company. Applicants for such substitute Warrants certificate shall also comply
with such other reasonable regulations as the Company may prescribe.

      SECTION 6. RESERVATION OF COMMON STOCK. There has been reserved, and the
Company shall at all times keep reserved so long as any Warrants remain
outstanding, out of its authorized share capital, such number of Common Stock as
shall be subject to purchase under all outstanding Warrants. Every transfer
agent for the Common Stock

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and other securities of the Company issuable upon the exercise of Warrants will
be irrevocably authorized and directed at all times to reserve such number of
authorized shares of Common Stock and other securities as shall be requisite for
such purpose. The Company will supply every such transfer agent with duly
executed stock and other certificates, as appropriate, for such purpose and will
provide or otherwise make available any cash which may be payable as provided in
Section 9 hereof.

      SECTION 7. WARRANT PRICE. "WARRANT PRICE" shall mean the price per Share
at which Shares shall at any time be purchasable upon the exercise of the
Warrants. The initial Warrant Price shall be $2.81, subject to adjustment
pursuant to Section 8 hereof.

      SECTION 8. ADJUSTMENT OF NUMBER AND KIND OF SECURITIES. The number and
kind of securities purchasable upon the exercise of the Warrants and the Warrant
Price shall be subject to adjustment from time to time upon the happening of
certain events, as follows:

      8.1. ADJUSTMENTS.

            (a) In case the Company shall (i) pay a dividend in Common Stock or
      make a distribution in Common Stock, (ii) subdivide its outstanding Common
      Stock, (iii) combine its outstanding Common Stock into a smaller number of
      shares of Common Stock, or (iv) issue, by reclassification of its Common
      Stock, other securities of the Company, the number of Shares or other
      securities purchasable upon exercise of the Warrants immediately prior
      thereto shall be adjusted so that each Warrantholder shall be entitled to
      receive the kind and number of shares of Common Stock or other securities
      of the Company which it would have owned or would have been entitled to
      receive immediately after the happening of any of the events described
      above, had the Warrants been exercised immediately prior to the happening
      of such event or any record date with respect thereto. Any adjustment made
      pursuant to this subsection 8.1(a) shall become effective immediately on
      the effective date of such event retroactive to the record date, if any,
      for such event.

            (b) In case the Company shall issue rights, options, warrants or
      convertible securities to all or substantially all holders of its Common
      Stock without any charge to such holders, entitling them to subscribe for
      or purchase shares of Common Stock at a price per share which, at the
      record date mentioned below, is lower than the then effective Warrant
      Price (calculated pursuant to this Section 8), the number of Shares
      thereafter purchasable upon the exercise of each Warrant shall be
      determined by multiplying the number of Shares theretofore purchasable
      upon exercise of the Warrant by a fraction, of which the numerator shall
      be the number of shares of Common Stock outstanding immediately prior to
      the issuance of such rights, options, warrants or convertible securities
      plus the number of additional Common Stock offered for subscription or
      purchase, and of which the denominator shall be the number of shares of
      Common Stock outstanding immediately prior to the issuance of such rights,
      options, warrants or convertible securities plus the number of shares
      which the aggregate offering price of the total number of shares offered
      would purchase at such then effective

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      Warrant Price. Such adjustment shall be made whenever such rights,
      options, warrants or convertible securities are issued, and shall become
      effective immediately and retroactive to the record date for the
      determination of shareholders entitled to receive such rights, options,
      warrants or convertible securities, provided no such adjustment shall be
      made for rights issued in connection with what is customarily referred to
      as a "poison pill" or "shareholder rights plan."

            (c) In case the Company shall distribute to all or substantially all
      holders of its Common Stock evidences of its indebtedness or assets
      (excluding cash dividends or distributions out of earnings) or rights,
      options, warrants or convertible securities containing the right to
      subscribe for or purchase Shares (excluding those referred to in
      subsection 8.1(b) above and rights in connection with a shareholder rights
      plan), then in each case the number of Shares thereafter purchasable upon
      the exercise of the Warrants shall be determined by multiplying the number
      of Shares theretofore purchasable upon exercise of the Warrants by a
      fraction, of which the numerator shall be the then effective Warrant Price
      as of the date of such distribution calculated pursuant to this Section 8,
      and of which the denominator shall be such then effective Warrant Price on
      such date minus the then fair value (determined as provided in
      subparagraph (f) below) of the portion of the assets or evidences of
      indebtedness so distributed or of such subscription rights, options,
      warrants or convertible securities applicable to one share. Such
      adjustment shall be made whenever any such distribution is made and shall
      become effective on the date of distribution retroactive to the record
      date for the determination of shareholders entitled to receive such
      distribution.

            (d) No adjustment in the number of Shares purchasable pursuant to
      the Warrants shall be required unless such adjustment would require an
      increase or decrease of at least one percent in the number of Shares then
      purchasable upon the exercise of the Warrants or, if the Warrants are not
      then exercisable, the number of Shares purchasable upon the exercise of
      the Warrants on the first date thereafter that the Warrants become
      exercisable; provided that any adjustments which by reason of this
      subsection 8.1(d) are not required to be made immediately shall be carried
      forward and taken into account in any subsequent adjustment.

            (e) Whenever the number of Shares purchasable upon the exercise of a
      Warrant is adjusted, as herein provided, the Warrant Price payable upon
      exercise of such Warrant shall be adjusted by multiplying such Warrant
      Price immediately prior to such adjustment by a fraction, of which the
      numerator shall be the number of Shares purchasable upon the exercise of
      the Warrant immediately prior to such adjustment, and of which the
      denominator shall be the number of Shares so purchasable upon the exercise
      of the Warrant immediately thereafter.

            (f) Whenever the number of Shares purchasable upon the exercise of
      Warrants is adjusted as herein provided, the Company shall cause to be
      promptly mailed to the Warrantholders by first class mail, postage
      prepaid, notice of such adjustment and a certificate of the chief
      financial officer of the Company setting forth the number of Shares
      purchasable upon the exercise of the Warrants after

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      such adjustment, a brief statement of the facts requiring such adjustment
      and the computation by which such adjustment was made.

            (g) For the purpose of this subsection 8.1, the term Common Stock
      shall mean (i) the class of Common Stock designated as the Common Stock of
      the Company at the date of this Agreement, or (ii) any other class of
      shares resulting from successive changes or reclassification of such
      Common Stock consisting solely of changes in par value, or from par value
      to no par value, or from no par value to par value. In the event that at
      any time, as a result of an adjustment made pursuant to this Section 8, a
      Warrantholder shall become entitled to purchase any securities of the
      Company other than Common Stock, (i) if the Warrantholders' right to
      purchase is on any other basis than that available to all holders of the
      Common Stock, the Company shall obtain an opinion of an independent
      investment banking firm valuing such other securities and (ii) thereafter
      the number of such other securities so purchasable upon exercise of the
      Warrants shall be subject to adjustment from time to time in a manner and
      on terms as nearly equivalent as practicable to the provisions with
      respect to the Common Stock contained in this Section 8.

            (h) Upon the expiration of any rights, options, warrants or
      conversion privileges, if such shall not have been exercised, the number
      of Shares purchasable upon exercise of the Warrants, to the extent the
      Warrants have not then been exercised, shall, upon such expiration, be
      readjusted and shall thereafter be such as they would have been had they
      been originally adjusted (or had the original adjustment not been
      required, as the case may be) on the basis of (A) the fact that the only
      shares of Common Stock so issued were the shares of Common Stock, if any,
      actually issued or sold upon the exercise of such rights, options,
      warrants or conversion privileges, and (B) the fact that such shares of
      Common Stock, if any, were issued or sold for the consideration actually
      received by the Company upon such exercise plus the consideration, if any,
      actually received by the Company for the issuance, sale or grant of all
      such rights, options, warrants or conversion privileges whether or not
      exercised; provided, however, that no such readjustment shall have the
      effect of decreasing the number of Shares purchasable upon exercise of the
      Warrants by an amount in excess of the amount of the adjustment initially
      made in respect of the issuance, sale or grant of such rights, options,
      warrants or conversion privileges.

      8.2. NO ADJUSTMENT FOR DIVIDENDS. Except as provided in subsection 8.1, no
adjustment to the Warrants or any provision or condition thereof in respect of
any dividends or distributions out of earnings shall be made during the term of
the Warrants or upon the exercise of Warrants.

      8.3. NO ADJUSTMENT IN CERTAIN CASES. No adjustments to the Warrants or any
provision or condition thereof shall be made pursuant to Section 3 or Section 8
hereof in connection with (i) the issuance of Common Stock upon exercise of the
Warrants, (ii) the grant or exercise of the options to purchase Common Stock
under the Company's Stock Plans or any future option plan for the sole benefit
of the Company's employees,

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consultants and directors, or (iii) the issuance of securities in an equity
financing regardless of the offering price.

      8.4. PRESERVATION OF PURCHASE RIGHTS UPON RECLASSIFICATION, CONSOLIDATION,
ETC. In case of any consolidation of the Company with or merger of the Company
into another entity or in case of any sale or conveyance to another entity of
the property, assets or business of the Company as an entirety or substantially
as an entirety, the Company or such successor or purchasing entity, as the case
may be, shall execute with the Warrantholders an agreement that the
Warrantholders shall have the right thereafter, upon exercise of the Warrants
and payment of the Warrant Price in effect immediately prior to such
consolidation, merger or sale, to purchase the kind and amount of shares and
other securities and property which it would have been entitled to receive after
the happening of such consolidation, merger, sale or conveyance had the Warrants
been exercised immediately prior thereto. In the event of a merger described in
Section 368(a)(2)(E) of the Internal Revenue Code of 1986 (or any successor
provision), in which the Company is the surviving corporation, the right to
purchase Shares under the Warrants shall terminate on the date of such merger
and thereupon the Warrants shall become null and void, but only if the
controlling corporation (after such event) shall agree to substitute for the
Warrants its warrants entitling the holder thereof to purchase the kind and
amount of shares and other securities and property which it would have been
entitled to receive had the Warrants been exercised immediately prior to such
merger. Any such agreements referred to in this subsection 8.4 shall provide for
adjustments, which shall be as nearly equivalent as may be practicable to the
adjustments provided for in Section 8 hereof, and shall contain substantially
the same terms, conditions and provisions as are contained herein immediately
prior to such event. The provisions of this subsection 8.4 shall similarly apply
to successive consolidations, mergers, sales or conveyances.

      8.5. NOMINAL VALUE OF COMMON STOCK. Before taking any action which would
cause an adjustment effectively reducing the portion of the Warrant Price
allocable to each Share below the then nominal value per Share issuable upon
exercise of the Warrants, the Company will take any corporate action which may,
in the opinion of its counsel, be necessary in order that the Company may
validly and legally issue fully paid and nonassessable Shares upon exercise of
the Warrants.

      8.6. INDEPENDENT PUBLIC ACCOUNTANTS. The Company may retain a firm of
independent public accountants of recognized national standing in the United
States (which may be any such firm regularly employed by the Company) to make
any computation required under this Section 8, and a certificate signed by such
firm shall be evidence of the correctness of any computation made under this
Section 8.

      8.7. STATEMENT ON WARRANT CERTIFICATES. Irrespective of any adjustments in
the number of securities issuable upon exercise of Warrants, Warrant
certificates theretofore or thereafter issued may continue to express the same
number of securities as are stated in the similar Warrant certificates initially
issuable pursuant to this Agreement. However, the Company may, at any time in
its reasonable discretion, make any change in the form of Warrant certificate
that it may deem appropriate and that does not affect the substance thereof; and
any Warrant certificate hereafter issued, whether upon registration of transfer

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of, or in exchange or substitution for, an outstanding Warrant certificate, may
be in the form so changed.

      SECTION 9. FRACTIONAL INTERESTS; MARKET PRICE. The Company shall not be
required to issue fractional Shares upon the exercise of any Warrant. If any
fraction of a Share would, except for the provisions of this Section 9, be
issuable on the exercise of any Warrant (or specified portion thereof), the
Company shall pay an amount in cash equal to the Market Price multiplied by such
fraction. For all purposes of this Agreement, the term "MARKET PRICE" as of any
specified date shall mean (i) if the Common Stock is traded in the United States
over-the-counter market and not on the Nasdaq Stock Market or on any United
States national securities exchange, the average of the mean between the bid and
asked prices of the Common Stock on each of the five consecutive trading days
immediately preceding the date in question, as reported by the National
Quotation Bureau Incorporated or an equivalent generally accepted reporting
service, or (ii) if the Common Stock is traded on the Nasdaq Stock Market or on
one or more United States national securities exchanges, the average, for the
five consecutive trading days immediately preceding the date in question, of the
daily closing price of the Common Stock on the Nasdaq Stock Market or the daily
closing price for consolidated transactions on the principal United States
national securities exchange on which the Common Stock is listed, or (iii) if
the Common Stock is not traded in the United States over-the-counter market, the
Nasdaq Stock Market or any United States national securities exchange, the
average, for the five consecutive trading days immediately preceding the date in
question, of the daily closing price of the Common Stock on the principal
non-United States exchange on which the Common Stock is listed. The daily
closing price referred to in clauses (ii) and (iii) above shall be the last
reported sale price on the day in question or, if no reported sale takes place
on such day, the average of the reported closing bid and asked prices.

      SECTION 10. NO RIGHTS AS SHAREHOLDER; NOTICES TO WARRANTHOLDERS. Nothing
contained in this Agreement or in the Warrants shall be construed as conferring
upon the Warrantholder or any transferee of a Warrant any rights as a
shareholder of the Company, including (without limitation) the right to vote,
receive dividends, consent or receive notices as a shareholder in respect of any
meeting of shareholders for the election of directors of the Company or any
other matter. If, however, at any time prior to the expiration of the Warrants
and prior to their exercise in full, any one or more of the following events
shall occur:

            (a) any action which would require an adjustment pursuant to Section
      8.1 or 8.4; or

            (b) a dissolution, liquidation or winding up of the Company (other
      than in connection with a consolidation, merger or sale of its property,
      assets and business as an entirety or substantially as an entirety) shall
      be proposed;

then the Company shall give notice in writing of such event to each of the
Warrantholders, as provided in Section 14 hereof, at least 10 days prior to the
date fixed as a record date or the date of closing the transfer books for the
determination of the

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shareholders entitled to any relevant dividend, distribution, subscription
rights or other rights or for the determination of shareholders entitled to vote
on such proposed dissolution, liquidation or winding up. Such notice shall
specify such record date or the date of closing the transfer books, as the case
may be. Failure to mail or receive such notice or any defect therein shall not
affect the validity of any action taken with respect thereto.

      SECTION 11. RESTRICTIONS ON TRANSFER; REGISTRATION RIGHTS.

            (a) There shall be no transfer of Warrants except as permitted
pursuant to Section 1.3 hereof. If any Holder proposes to sell or otherwise
transfer any Shares, and if such Shares are not then registered for resale
pursuant to an effective registration statement under the Act, the Holder
proposing to make such transfer shall give written notice to the Company
describing briefly the manner in which any such proposed transfer is to be made;
and no such transfer shall be made unless the Company shall notify such Holder
that in the opinion of Company's counsel, registration under the Act is not
required with respect to such transfer.

            (b) If at any time during the period prior to the Termination Date
the Shares are not subject to an effective registration statement under the Act
(a "REGISTRATION STATEMENT"), the Company shall be obligated to the
Warrantholders and the registered holders of the Shares issued upon exercise of
the Warrants (collectively with the Warrantholders, the "HOLDERS"), as follows:

                  (i) Whenever during the period beginning on the Commencement
      Date and ending on the Termination Date, the Company proposes to file with
      the Securities and Exchange Commission (the "COMMISSION") a Registration
      Statement (other than a registration statement on Form S-8 (or other form)
      relating solely to securities issued pursuant to an employee benefit plan,
      or a registration statement on Form F-4 or S-4 or any successor form
      thereto), the Company shall, at least 20 days prior to each such proposed
      filing, give written notice thereof to the Holders at their respective
      addresses appearing on the records of the Company, and shall offer to
      include and shall include in such filing any Shares as to which written
      requests for such inclusion are received by the Company from Holders not
      more than 10 days after such Company's notice is mailed to the Holders.
      The Shares which are the subject of valid requests from Holders are
      hereinafter referred to as the "PIGGYBACK SHARES." If such registration
      statement relates in whole or in part to an underwritten public offering
      of the Common Stock by the Company, the right of any Holder to
      registration pursuant to this Section 11(b) shall be conditioned upon such
      Holder's participation in any underwriting of the Company's public
      offering. All Holders proposing to distribute their Piggyback Shares
      through such underwriting shall (together with the Company and other
      holders of Common Stock participating in such underwriting) enter into an
      underwriting agreement in customary form with the underwriter or
      underwriters selected for such underwriting by the Company. In addition,
      if, after the number of Piggyback Shares is

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      determined, the managing underwriter of such offering determines that
      marketing factors require a limitation on the number of shares of Common
      Stock to be underwritten other than those to be offered by the Company for
      its own account, the managing underwriter may exclude any or all of the
      Piggyback Shares from such registration statement and underwriting, but
      only to the extent that the Company excludes Common Stock which other
      shareholders of the Company have requested the Company to include in such
      registration statement and underwriting pursuant to "piggyback rights"
      similar to those granted in this Section 11(b) (such other Common Stock
      which is the subject of such requests are hereinafter referred to as
      "OTHER PIGGYBACK SHARES"). In the event that any Piggyback Shares are so
      excluded, the number of Piggyback Shares and Other Piggyback Shares that
      shall be included in such registration statement and underwriting shall be
      allocated equally among all Holders and the holders of Other Piggyback
      Shares in proportion, as nearly as practicable, to the total number of
      Piggyback Shares and Other Piggyback Shares.

            (c) In connection with any Registration Statement filed pursuant to
paragraph (b) of this Section 11, the Company shall take such action as may be
necessary or appropriate to comply with the securities or blue sky laws of such
states of the United States as shall reasonably be requested by the Holders, and
shall do any and all other acts which may be necessary or advisable to permit
the proposed sale or other disposition of the Shares in any such state; provided
that in no event shall the Company be obligated in connection therewith to
qualify as a foreign corporation or as a dealer in any jurisdiction where it is
not already so qualified, or to execute a general consent for service of process
in suits other than those arising out of the offer and sale of the Shares, or to
take any action which would subject it to taxation in any jurisdiction where it
is not then so subject.

            (d) The Company's obligations under paragraph (b) of this Section 11
with respect to any Holder shall be conditioned in each instance upon the timely
receipt by the Company in writing of (i) information from such Holder as to the
proposed plan of distribution of such Holder's Shares to be included in a
Registration Statement, and (ii) such other information as may be required by
law from such holder, or its underwriter or other agent, for inclusion in such
Registration Statement.

            (e) Each Holder will not make any sale of the Shares, pursuant to
the Registration Statement referred to in this Section 11 without effectively
causing the prospectus delivery requirements under the Act to be satisfied. Each
Holder acknowledges that there may occasionally be times when the Company must
suspend the use of the prospectus forming a part of the Registration Statement
until such time as an amendment to such registration statement has been field by
the Company and declared effective by the Commission or until the Company has
amended or supplemented such prospectus. The Company will use its best efforts
to cause such amended registration statement to be declared effective and/or to
deliver such amended or supplemented prospectus as soon as possible. Each Holder
hereby covenants that it will not sell any Shares pursuant to said prospectus
without first confirming with the Company that the Registration Statement has
not been suspended, and during the period commencing at the

<PAGE>

time at which the Company gives the Holder notice of the suspension of the use
of said prospectus and ending at the time the Company gives the Holder notice
that the Holder may thereafter effect sales pursuant to said prospectus.

            (f) The Company shall pay all fees, disbursements and out-of-pocket
expenses (other than any Holder's brokerage fees and commissions and legal fees)
payable in connection with (i) any Registration Statement filed under Section
11(b), and (ii) compliance with applicable state securities and blue sky laws.
In connection with registrations pursuant to Section 11(b) (i) hereof, each
Holder shall also pay its pro-rata portion of any filing fee required by the
Securities and Exchange Commission. The Company at its expense will supply the
Holders of Shares included in a Registration Statement with copies of such
Registration Statement and the prospectus included therein and other related
documents and opinions and no-action letters, in such quantities as may be
reasonably requested by such Holders. In connection with each Registration
Statement, the Company shall furnish to Holders of Shares included therein such
opinions of counsel, comfort letters of accountants, certificates and other
documents that are customary in connection with underwritten public offerings
and that are reasonably requested by such Holders.

            (g) The Company shall not be required by this Section 11 to include
or maintain in any Registration Statement any Shares which, in the opinion of
counsel for the Company, could be sold pursuant to Rule 144 under the Act in any
three-month period without volume limitation.

      SECTION 12. INDEMNIFICATION.

            (a) In the event that any Registration Statement is filed pursuant
to Section 11 hereof, the Company will indemnify and hold harmless each Holder
identified as a selling security holder therein, and each person, if any, who
controls such Holder within the meaning of the Act, against any and all losses,
claims, damages or liabilities, joint or several (including any reasonable
investigation, legal and other expenses incurred in connection with, and any
amount paid in settlement of, any action, suit or proceeding or any claim
asserted), to which they or any of them may become subject under the Act, the
Securities Exchange Act of 1934, as amended (the "EXCHANGE ACT") or other
federal or state law or regulation, at common law or otherwise, insofar as such
losses, claims, damages or liabilities (or actions in respect thereof) arise out
of or are based upon (i) any untrue statement or alleged untrue statement of a
material fact contained in any such Registration Statement, any related
preliminary prospectus, final prospectus, or amendment thereof or supplement
thereto, or any related blue sky filing, or (ii) the omission or alleged
omission to state therein a material fact required to be stated therein or
necessary to make the statements therein, in light of the circumstances under
which they were made, not misleading; provided that the Company shall not be
liable under this Section 12(a) in any such case to the extent that any such
losses, claims, damages or liabilities arise solely out of or are based upon an
untrue statement of a material fact contained in, or any omission of a material
fact from, such Registration Statement, preliminary prospectus, final prospectus
or amendment thereof or supplement thereto in reliance upon, and in conformity
with, information furnished in writing to the Company by such Holder
specifically for use therein, provided further, that the indemnification

<PAGE>

contained in this Section 12(a) with respect to any prospectus after is has been
amended or supplemented, shall not inure to the benefit of any Holder from whom
the person asserting such loss, claim, damage, or liability shall have purchased
Shares, that are the subject thereof if, after copies thereof have been
delivered by the Company to such Holder, such Holder shall have failed to send
or give a copy of the prospectus as then amended or supplemented, as the case
may be, to such person at or prior to the confirmation of such sale of such
Shares, to such person, and if such loss, claim, damage or liability would not
have arisen but for the failure of such Holder to deliver the same. This
indemnity will be in addition to any liability which the Company may otherwise
have.

            (b) Each Holder who is identified as a selling security holder in a
filed Registration Statement will severally, and not jointly, indemnify and hold
harmless the Company, each other person referred to in subparts (1), (2) and (3)
of Section 11(a) of the Act in respect of the Registration Statement, and each
person, if any, who controls the Company or any such person within the meaning
of Section 15 of the Act, against any and all losses, claims, damages or
liabilities (including any reasonable investigation, legal and other expenses
incurred in connection with, and any amount paid in settlement of, any action,
suit or proceeding or any claim asserted), to which they, or any of them, may
become subject under the Act, the Exchange Act or other federal or state law or
regulation, at common law, or otherwise, insofar as such losses, claims, damages
or liabilities (or actions in respect thereof) arise out of or are based upon
(i) any untrue statement or alleged untrue statement of a material fact
contained in such Registration Statement, any related preliminary prospectus,
final prospectus or amendment thereof or supplement thereto, or any related blue
sky filing, or (ii) the omission or alleged omission to state therein a material
fact required to be stated therein or necessary to make the statements therein,
in light of the circumstances under which they were made, not misleading, in
each case to the extent, but only to the extent, that such untrue statement or
omission was made in such Registration Statement, preliminary prospectus, final
prospectus or amendment thereof or supplement thereto in reliance upon, and in
conformity with, information furnished in writing to the Company by such Holder
specifically for use therein. This indemnity will be in addition to any
liability which a Holder may otherwise have to the Company.

            (c) Any party that proposes to assert the right to be indemnified
under this Section 12 shall, promptly after receipt of notice of the
commencement of any action, suit or proceeding against such party in respect of
which a claim is to be made against an indemnifying party or parties under this
Section, notify each such indemnifying party of the commencement thereof,
enclosing a copy of all papers served. No indemnification provided for in
Section 12(a) or 12(b) shall be available to any party who shall fail to give
notice as provided in this Section 12(c) if the party to whom notice was not
given was unaware of the proceeding to which such notice would have related and
was materially prejudiced by the failure to give such notice, but the omission
so to notify such indemnifying party of any such action, suit or proceeding
shall not relieve it from any liability that it may have to any indemnified
party otherwise than under this Section 12 or Section 13. In case any such
action, suit or proceeding is brought against any indemnified party and it
notifies the indemnifying party of the commencement thereof, such indemnifying
party will be entitled to participate in, and, to

<PAGE>

the extent that it may wish, jointly with any other indemnifying party similarly
notified, to assume the defense thereof with counsel reasonably satisfactory to
such indemnified party, and, after notice from the indemnifying party to such
indemnified party of its election so to assume the defense thereof and the
approval by the indemnified party of such counsel (which approval shall not
unreasonably be withheld), the indemnifying party shall not be liable to such
indemnified party for any legal or other expenses, except as provided below and
except for the reasonable costs of investigation subsequently incurred by such
indemnified party in connection with the defense thereof. The indemnified party
shall have the right to employ its own counsel in any such action, suit or
proceeding but the fees and expenses of such counsel shall be at the expense of
such indemnified party unless (i) the employment of counsel by such indemnified
party has been authorized in writing by the indemnifying parties, (ii) the
indemnified party shall have reasonably concluded that there may be differing or
additional defenses available to it and not to one or more of the indemnifying
parties in such action, suit or proceeding (in which case the indemnifying
parties shall not have the right to direct the defense of such action, suit or
proceeding on behalf of the indemnified party), or (iii) the indemnifying
parties shall not have employed counsel to assume the defense of such action
within a reasonable time after notice of the commencement thereof, in each of
which cases the fees and expenses of the indemnified party's counsel shall be at
the expense of the indemnifying parties; however, the indemnifying party shall
not, in connection with any one such action, suit or proceeding or separate but
substantially similar or related actions, suits or proceedings in the same
jurisdiction arising out of the same general allegations or circumstances, be
liable for the reasonable fees and expenses of more than one separate firm of
attorneys for the Holders and controlling persons, which firm shall be
designated in writing by a majority in interest of such Holders and controlling
persons (based upon the value of the Shares included in the Registration
Statement). An indemnifying party shall not be liable for any settlement of any
action, suit, proceeding or claim effected without its written consent.

      SECTION 13. CONTRIBUTION. In order to provide for just and equitable
contribution in circumstances in which the indemnification provided for in
Section 12 is due in accordance with its terms but for any reason is held to be
unavailable or insufficient to hold harmless an indemnified party, the Company
(including for this purpose any controlling person of the Company, any director
of the Company and any officer of the Company who signed the Registration
Statement) on the one hand, and the Holders (including for this purpose any
controlling persons thereof) on the other hand, shall, in lieu of indemnifying
such indemnified party, contribute to the aggregate losses, claims, damages or
liabilities referred to in Section 12 above (including any investigation, legal
and other expenses reasonably incurred in connection with, and any amount paid
in settlement of, any action, suit or proceeding or any claims asserted, but
after deducting any contribution received by or payable to the Company from
other persons other than the Holders, such as other selling securityholders,
persons who control the Company within the meaning of the Act, officers of the
Company who signed the Registration Statement, and directors of the Company),
(a) in such proportion as is appropriate to reflect the relative benefits
received by the Company and the Holders from the offering or offerings covered
by the Registration Statement or, (b) if the allocation provided by clause (a)
above is not permitted by applicable law, in such proportion as is appropriate
to

<PAGE>

reflect not only the relative benefits referred to in clause (a) above but also
the relative fault of the Company and the Holders in connection with the
statements or omissions which resulted in such losses, claims, damages,
liabilities or expenses, as well as any other relevant equitable considerations.
The relative benefits received by the Company on the one hand and any Holder on
the other hand shall be deemed to be in the same proportion as (x) the total
proceeds (if any) received by the Company from the offering or offerings covered
by the Registration Statement (net of underwriting discounts but before
deducting expenses, if applicable), plus all cash proceeds received by the
Company from the exercise of the Warrants for the Shares of such Holder included
in the Registration Statement, bear to (y) the total proceeds received by such
Holder from the sale of Shares included in the Registration Statement. The
relative fault of the Company and any Holder shall be determined by reference
to, among other things, whether the untrue or alleged untrue statement of a
material fact or omission related to information supplied by the Company or such
Holder, and their relative intent, knowledge, access to information and
opportunity to correct or prevent such statement or omission. The Company,
Sunrise, and the Holders agree that it would not be just and equitable if
contribution pursuant to this Section 13 were determined by pro rata allocation
(even if the Holders were treated as one entity for such purpose) or by any
other method of allocation which does not take account of the equitable
considerations referred to above. Notwithstanding the provisions of this Section
13, in no case shall any Holder (except as may be provided by agreement among
them) be liable or responsible for any amount in excess of the proceeds received
by such Holder from the sale of the Shares included in the Registration
Statement; provided that no person guilty of fraudulent misrepresentation
(within the meaning of Section 11(f) of the Act) shall be entitled to
contribution from any person who was not guilty of such fraudulent
misrepresentation. For purposes of this Section 13, each person, if any, who
controls a Holder within the meaning of Section 15 of the Act or Section 20(a)
of the Exchange Act shall have the same rights to contribution as such Holder,
and each person, if any, who controls the Company within the meaning of the
Section 15 of the Act or Section 20(a) of the Exchange Act, each director of the
Company and each officer of the Company who shall have signed the Registration
Statement, shall have the same rights to contribution as the Company, subject in
each case to clauses (i) and (ii) in the immediately preceding sentence of this
Section 13. Any party entitled to contribution will, promptly after receipt of
notice of commencement of any action, suit or proceeding against such party in
respect of which a claim for contribution may be made against another party or
parties under this Section 13, notify such party or parties from whom
contribution may be sought, and the omission so to notify such party or parties
from whom contribution may be sought shall relieve the party or parties from
whom contribution may be sought (if such party was unaware of such action, suit
or proceeding and was materially prejudiced by such omission) from any liability
under this Section 13, but not from any other obligation it or they may have
hereunder or otherwise than under this Section 13. No party shall be liable for
contribution with respect to any settlement of an action, suit, proceeding or
claim effected without its written consent. The obligations of the Holders to
contribute pursuant to this Section 13 are several in proportion to their
respective number of Shares included in the Registration Statement, and not
joint.

      SECTION 14. NOTICES. Any notice pursuant to this Agreement shall be in
writing and shall be deemed to have been duly given (i) if given by facsimile
transmission on the

<PAGE>

business day on which such transmission is sent and confirmed, (ii) if given by
air courier, two business days following the date it was sent or (iii) if mailed
by certified mail, return receipt requested, ten business days following the
date it was mailed, to the following addresses (unless another address is herein
specified):

            (a) If to a Holder, addressed to: Sunrise Securities Corp., 135 East
      57th Street, 11th Floor, New York, New York 10022, Attention: Mr. Derek
      Caldwell (fax: 212-421-5924), with a copy to Mintz, Levin, Cohn, Ferris,
      Glovsky and Popeo, P.C., Chrysler Center, 666 Third Avenue, New York, New
      York 10017. Attention Todd Mason, Esq. (Fax: (212) 983-3115).

            (b) If to the Company, addressed to: 330 Nevada Street, Newton,
      Massachusetts 02160, Attention: Chief Executive Officer (fax:
      617-928-0821) with a copy to: Testa, Hurwitz & Thibeault, LLP, 125 High
      Street, Boston, Massachusetts 02110, Attention: Rufus C. King, Esq. (fax:
      617-248-7100)

      Each party may from time to time change the address or fax number to which
notices to it are to be delivered or mailed hereunder by notice in accordance
herewith to the other party.

      SECTION 15. SUCCESSORS. All the covenants and provisions of this Agreement
by or for the benefit of the Company, Sunrise and the Holders shall bind and
inure to the benefit of their respective successors and assigns.

      SECTION 16. MERGER OR CONSOLIDATION OF THE COMPANY. The Company shall not
merge or consolidate with or into any other corporation or sell all or
substantially all of its property to another corporation, unless the provisions
of Section 8.4 are complied with.

      SECTION 17. APPLICABLE LAW; SUBMISSION TO JURISDICTION. THIS AGREEMENT
SHALL BE DEEMED TO BE A CONTRACT MADE UNDER THE LAWS OF THE COMMONWEALTH OF
MASSACHUSETTS AND FOR ALL PURPOSES SHALL BE CONSTRUED IN ACCORDANCE WITH THE
INTERNAL LAWS OF SAID STATE (WITHOUT REFERENCE TO ITS RULES AS TO CONFLICTS OF
LAWS). The Company and the Holders hereby agree to the exclusive jurisdiction of
the courts of the Commonwealth of Massachusetts or the federal courts sitting in
the Commonwealth of Massachusetts in connection with any action arising out of
this Agreement.

      SECTION 18. BENEFITS OF THIS AGREEMENT. Nothing in this Agreement shall be
construed to give to any person or corporation other than the Company, the
Warrantholders and holders of Shares any legal or equitable right, remedy or
claim under this Agreement. This Agreement shall be for the sole and exclusive
benefit of the Company and the Holders.

<PAGE>

      SECTION 19. AMENDMENT AND WAIVER. This Agreement and the Warrants may only
be amended, or any term hereof waived, in writing signed by the Company and
Warrantholders holding a majority of the Shares issued or issuable upon exercise
of the Warrants, whether or not an individual Warrantholder consents thereto.

                     [REST OF PAGE INTENTIONALLY LEFT BLANK]

<PAGE>

      IN WITNESS WHEREOF, the parties have caused this Placement Agent Warrant
Agreement to be duly executed, all as of the date and year first above written.

                                   MATRITECH, INC.

                                   By:
                                       ------------------------------------
                                       Name:
                                       Title:

                                   SUNRISE SECURITIES CORP.

                                   By:
                                       ------------------------------------
                                       Name:
                                       Title:

<PAGE>

            "THE WARRANTS REPRESENTED BY THIS CERTIFICATE, AND THE SECURITIES
            ISSUABLE UPON EXERCISE OF SUCH WARRANTS, HAVE NOT BEEN REGISTERED
            UNDER THE UNITED STATES SECURITIES ACT OF 1933 OR THE SECURITIES
            LAWS OF ANY STATE OF THE UNITED STATES. SUCH WARRANTS AND SECURITIES
            MAY NOT BE SOLD, ASSIGNED, EXCHANGED, HYPOTHECATED OR OTHERWISE
            TRANSFERRED IN ANY MANNER EXCEPT IN COMPLIANCE WITH SECTION 11 OF
            THE PLACEMENT AGENT WARRANT AGREEMENT BY AND BETWEEN THE ISSUER AND
            SUNRISE SECURITIES CORP. DATED FEBRUARY 13, 2002."

                                                   WARRANT CERTIFICATE NO. PAW-1

                                 MATRITECH, INC.

                            (ORGANIZED UNDER THE LAWS
                            OF THE STATE OF DELAWARE)

                        WARRANTS TO PURCHASE COMMON STOCK

      This certifies that, for value received, SUNRISE SECURITIES CORP. (the
"WARRANTHOLDER") is the registered owner of 174,425 warrants (the "WARRANTS") to
purchase from Matritech, Inc. (the "COMPANY"), at any time during the period
commencing at 9:00 a.m., Eastern Time, on February 13, 2002 and ending at 5:00
p.m., Eastern Time, on February 13, 2005, exercisable at $2.81 per share (the
"WARRANT PRICE"), up to 174,425 shares of Common Stock. The Warrants are subject
to, and each Warrantholder, by acceptance of this certificate, consents to all
the terms and provisions of the Placement Agent Warrant Agreement dated as of
February 13, 2002, between the Company and the Warrantholder, pursuant to which
the Warrants evidenced hereby were issued (the "WARRANT AGREEMENT").

      The Warrants evidenced hereby may be exercised in whole or in part by
presentation of this Warrant Certificate with the Purchase Form herein duly
executed (with a signature guarantee as provided therein), and simultaneous
payment of the Warrant Price for each Warrant exercised, at the principal office
of the Company. Payment of such price shall be made at the option of each
Warrantholder in cash or by certified or cashier's check, in next day funds.

      Upon any partial exercise of the Warrants evidenced hereby, there shall be
signed and issued to the Warrantholder effecting such partial exercise a new
Warrant Certificate

<PAGE>

in respect of the Common Stock as to which the Warrants evidenced hereby shall
not have been exercised. These Warrants may be exchanged at the office of the
Company by surrender of this Warrant Certificate properly endorsed for one or
more new Warrants of the same aggregate number of shares of Common Stock as here
evidenced by the Warrant or Warrants exchanged. No fractional shares of Common
Stock will be issued upon the exercise of rights to purchase hereunder, but the
Company shall pay the cash value of any fraction upon the exercise of one or
more Warrants. These Warrants are transferable at the office of the Company in
the manner and subject to the limitations set forth in the Warrant Agreement.

      This Warrant Certificate does not entitle any Warrantholder to any of the
rights of a shareholder of the Company.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

<PAGE>

MATRITECH, INC.

By:
    -------------------------------
    Name:
    Title:

ATTEST:

----------------------------------

Title:
    -------------------------------

Dated:                   , 2002
      -----------------

<PAGE>

                                  PURCHASE FORM

Matritech, Inc.
330 Nevada Street
Newton, Massachusetts 02160

      Pursuant to paragraph 3(a) of the Warrant Agreement, the undersigned
hereby irrevocably elects to exercise the right of purchase represented by this
Warrant Certificate for, and to purchase thereunder, __________ shares of Common
Stock ("Common Stock") provided for therein, and requests that certificates for
such Common Stock be issued in the name of:

                       -----------------------------------
  (Please Print or Type Name(s), Address and Taxpayer Identification Number(s))

                       -----------------------------------

                       -----------------------------------

                       -----------------------------------

If this Warrant Certificate is hereby being exercised with respect to fewer than
all the Common Stock specified herein, please issue a new Warrant Certificate
for the unexercised balance of the Warrants, registered in the name of the
undersigned Warrantholder or his assignee as below indicated and delivered to
the address stated below.

Dated: _______________________

Name of Warrantholder(s)
    or Assignee(s) (Please Print):
                                   --------------------------------------

                                   --------------------------------------

Address (Please Print):
                       --------------------------------------------------

                       --------------------------------------------------

Signature(s):
             ------------------------------------------------------------

             ------------------------------------------------------------

            Note: The above signature(s) must correspond exactly with the
      name(s) as written upon the face of this Warrant Certificate, without
      alteration or enlargement or any change whatever, unless the Warrants have
      been assigned.

<PAGE>

                                   ASSIGNMENT
                (To be signed only upon assignment of Warrants)

      FOR VALUE RECEIVED, the undersigned hereby sells, assigns and transfers
unto

                       -----------------------------------

                       -----------------------------------

                       -----------------------------------

     (Name(s) and Address(es) of Assignee(s) Must be Printed or Typewritten)

the within Warrants, hereby irrevocably constituting and appointing
________________________ the undersigned's attorney-in-fact to transfer said
Warrants on the books of the Company, with full power of substitution.

Dated:
        ----------         ------------------------------------

                           ------------------------------------
                           Signature(s) of Registered Holder(s)

            Note: The above signature(s) must correspond exactly with the
      name(s) as written upon the face of this Warrant Certificate, without
      alteration or enlargement or any change whatever.<PAGE>

                                   EXHIBIT 4.4

        Placement Agent Warrant Agreement Dated March 4, 2002 Between the
                    Registrant and Sunrise Securities Corp.

<PAGE>

                                 MATRITECH, INC.

                                       AND

                            SUNRISE SECURITIES CORP.

                                -----------------

                        PLACEMENT AGENT WARRANT AGREEMENT

                              Dated: March 4, 2002

<PAGE>

      THIS WARRANT AGREEMENT (this "AGREEMENT") dated March 4, 2002 is made and
entered into by and between Matritech, Inc., a corporation organized under the
laws of the State of Delaware (the "COMPANY"), and Sunrise Securities Corp.
("SUNRISE").

      Subject to the terms and conditions hereof, the Company agrees to issue to
Sunrise, pursuant to the Engagement Letter dated December 20, 2001, by and
between the Company and Sunrise, warrants as hereinafter described (the
"Warrants") exercisable at $2.81 per share to purchase up to 40,950 shares of
Common Stock, 10% of the total number of shares of Common Stock sold in the
offering. As used herein, the terms "Share" or "Shares" shall mean collectively
the Common Stock issuable upon exercise of the Warrants together with any other
securities issuable upon such exercise as provided in Section 8 of this
Agreement. Except, where otherwise specified, the terms of this Agreement shall
apply to all registered holders of the Warrants (together with Sunrise, the
"Warrantholders").

      For the purpose of defining the terms and provisions of the Warrants and
the respective rights and obligations thereunder, the Company and Sunrise, for
value received, hereby agree as follows:

      SECTION 1. TRANSFERABILITY AND FORM OF WARRANTS.

      1.1. REGISTRATION. The Warrants shall be numbered and shall be registered
on the books of the Company when issued, in accordance with Delaware corporate
practice.

      1.2. TRANSFER. The Warrants shall be transferable only on the books of the
Company maintained at its principal office in Newton, Massachusetts, or wherever
its principal office may then be located, upon delivery thereof duly endorsed by
the Warrantholder seeking such transfer or by its duly authorized attorney or
representative, accompanied by proper evidence of succession, assignment or
authority to transfer. Upon any registration of transfer, the Company shall
execute and deliver new Warrants to the person entitled thereto.

      1.3. LIMITATIONS ON TRANSFER OF THE WARRANTS. Subject to the provisions of
Section 11 of this Agreement, the Warrants shall not be sold, assigned,
hypothecated or otherwise transferred, except to: (i) one or more persons, each
of whom on the date of transfer is an officer of Sunrise; (ii) a general
partnership or general partnerships, all the general partners in which are
Sunrise or controlling persons of Sunrise and one or more persons, each of whom
on the date of transfer is an officer of Sunrise; (iii) a successor to Sunrise
by merger or consolidation; or (iv) a purchaser of all or substantially all of
Sunrise's assets. The term "Warrants" shall include any and all warrants
outstanding pursuant to this Agreement, including those evidenced by a
certificate or certificates issued upon division, exchange, substitution or
transfer pursuant to this Agreement.

      1.4. FORM OF WARRANTS. The form of certificate evidencing the Warrants
shall be substantially as set forth in EXHIBIT A attached hereto. Certificates
evidencing the Warrants shall be executed on behalf of the Company by its
Chairman, President or by

<PAGE>

any Vice President, shall be attested to by its Secretary or any Assistant
Secretary, and shall be dated as of the date of execution thereof.

      1.5. LEGEND ON COMMON STOCK. The Warrants, and the Shares have not been
registered under the Securities Act of 1933, as amended (the "ACT"). Each
certificate for Shares shall bear the following legend unless, at the time of
exercise, such Shares are the subject of a currently effective registration
statement under the Act:

      "THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED
      UNDER THE UNITED STATES SECURITIES ACT OF 1933 OR THE SECURITIES LAWS OF
      ANY STATE OF THE UNITED STATES. SUCH SECURITIES MAY NOT BE SOLD, ASSIGNED,
      EXCHANGED, HYPOTHECATED OR OTHERWISE TRANSFERRED IN ANY MANNER EXCEPT IN
      COMPLIANCE WITH SECTION 11 OF THE WARRANT AGREEMENT BY AND BETWEEN THE
      ISSUER AND SUNRISE SECURITIES CORP. DATED MARCH 4, 2002."

      Any certificate issued at any time in exchange or substitution for any
certificate bearing such legend (except a new certificate issued upon completion
of a public distribution pursuant to a registration statement under the Act of
the securities represented thereby) shall also bear the above legend unless, in
the opinion of the Company's counsel, the securities represented thereby need no
longer be subject to such restrictions.

      SECTION 2. EXCHANGE OF WARRANT CERTIFICATE. Any Warrant certificate may be
exchanged for another certificate or certificates entitling a Warrantholder to
purchase a like aggregate number of Shares as the certificate or certificates
surrendered then entitles such Warrantholder to purchase. Any Warrantholder
desiring to exchange a Warrant certificate shall make such request in writing
delivered to the Company, and shall surrender, properly endorsed, the
certificate evidencing the Warrant to be so exchanged. Thereupon, the Company
shall execute and deliver to the person entitled thereto a new Warrant
certificate as so requested.

      SECTION 3. TERM OF WARRANTS; EXERCISE OF WARRANTS

      (a) Subject to the terms of this Agreement, each Warrantholder shall have
the right, at any time during the period commencing at 9:00 a.m., Eastern Time,
on March 4, 2002 (the "COMMENCEMENT DATE") and ending at 5:00 p.m., Eastern
Time, on March 4, 2005 (the "TERMINATION DATE"), to purchase from the Company up
to the number of fully paid and nonassessable Shares which such Warrantholder
may at the time be entitled to purchase pursuant to this Agreement, upon
surrender to the Company at its principal office of the certificate evidencing
the Warrants to be exercised, with the purchase form on the reverse thereof duly
completed and signed, and upon payment to the Company of the Warrant Price (as
defined in and determined in accordance with the provisions of this Section 3
and Sections 7 and 8 hereof) for the number of Shares in respect of which such
Warrants are then exercised, but in no event for fewer than 100 Shares (unless
fewer than

<PAGE>

an aggregate of 100 Shares are then purchasable under all outstanding Warrants
held of record by a Warrantholder). Payment of the aggregate Warrant Price shall
be made in cash or by certified or cashier's check, in next day funds, or any
combination thereof.

            (b) Upon surrender of Warrant certificates and payment of the
Warrant Price, the Company shall issue and cause to be delivered with all
reasonable dispatch to or upon the written order of a Warrantholder, and
(subject to Section 11 hereof) in such name or names as such Warrantholder may
designate, a certificate or certificates for the number of full Shares so
acquired upon the exercise of the Warrant, together with cash, as provided in
Section 9 hereof, in respect of any fractional Shares otherwise issuable upon
such surrender. Such certificate or certificates shall be deemed to have been
issued and any person so designated to be named therein shall be deemed to have
become a holder of record of such Shares as of the date of surrender of the
Warrants being exercised and payment of the Warrant Price notwithstanding that
the certificate or certificates representing such securities shall not actually
have been delivered or that the stock transfer books of the Company shall then
be closed. The Warrants shall be exercisable at the election of a Warrantholder
either in full or from time to time in part and, in the event that a certificate
evidencing Warrants is exercised in respect of fewer than all of the Shares
specified therein at any time prior to the Termination Date, a new certificate
evidencing the remaining portion of the Warrants shall be issued by the Company.

      SECTION 4. PAYMENT OF TAXES. The Company will pay all taxes and fees, if
any (other than any income taxes that may be imposed on the exercise of the
Warrants or on the subsequent sale of the Shares), attributable to the initial
issuance of the Warrants or the issuance of Shares upon exercise of the
Warrants; provided that the Company shall not be required to pay any tax or fee
which may be payable in respect of any secondary transfer of the Warrants or
such Shares.

      SECTION 5. MUTILATED OR MISSING WARRANTS. In case the certificate or
certificates evidencing any Warrants shall be mutilated, lost, stolen or
destroyed, the Company shall, at the request of the affected Warrantholder,
issue and deliver in exchange and substitution for and upon cancellation of the
mutilated certificate or certificates, or in lieu of and substitution for the
certificate or certificates lost, stolen or destroyed, a new Warrant certificate
or certificates of like tenor and representing an equivalent right or interest,
but only upon receipt of evidence satisfactory to the Company of the loss, theft
or destruction of such Warrant and, if requested, at the cost and expense of the
Warrantholder, a bond of indemnity in form and amount satisfactory to the
Company. Applicants for such substitute Warrants certificate shall also comply
with such other reasonable regulations as the Company may prescribe.

      SECTION 6. RESERVATION OF COMMON STOCK. There has been reserved, and the
Company shall at all times keep reserved so long as any Warrants remain
outstanding, out of its authorized share capital, such number of Common Stock as
shall be subject to purchase under all outstanding Warrants. Every transfer
agent for the Common Stock and other securities of the Company issuable upon the
exercise of Warrants will be

<PAGE>

irrevocably authorized and directed at all times to reserve such number of
authorized shares of Common Stock and other securities as shall be requisite for
such purpose. The Company will supply every such transfer agent with duly
executed stock and other certificates, as appropriate, for such purpose and will
provide or otherwise make available any cash which may be payable as provided in
Section 9 hereof.

      SECTION 7. WARRANT PRICE. "WARRANT PRICE" shall mean the price per Share
at which Shares shall at any time be purchasable upon the exercise of the
Warrants. The initial Warrant Price shall be $2.81, subject to adjustment
pursuant to Section 8 hereof.

      SECTION 8. ADJUSTMENT OF NUMBER AND KIND OF SECURITIES. The number and
kind of securities purchasable upon the exercise of the Warrants and the Warrant
Price shall be subject to adjustment from time to time upon the happening of
certain events, as follows:

      8.1. ADJUSTMENTS.

            (a) In case the Company shall (i) pay a dividend in Common Stock or
      make a distribution in Common Stock, (ii) subdivide its outstanding Common
      Stock, (iii) combine its outstanding Common Stock into a smaller number of
      shares of Common Stock, or (iv) issue, by reclassification of its Common
      Stock, other securities of the Company, the number of Shares or other
      securities purchasable upon exercise of the Warrants immediately prior
      thereto shall be adjusted so that each Warrantholder shall be entitled to
      receive the kind and number of shares of Common Stock or other securities
      of the Company which it would have owned or would have been entitled to
      receive immediately after the happening of any of the events described
      above, had the Warrants been exercised immediately prior to the happening
      of such event or any record date with respect thereto. Any adjustment made
      pursuant to this subsection 8.1(a) shall become effective immediately on
      the effective date of such event retroactive to the record date, if any,
      for such event.

            (b) In case the Company shall issue rights, options, warrants or
      convertible securities to all or substantially all holders of its Common
      Stock without any charge to such holders, entitling them to subscribe for
      or purchase shares of Common Stock at a price per share which, at the
      record date mentioned below, is lower than the then effective Warrant
      Price (calculated pursuant to this Section 8), the number of Shares
      thereafter purchasable upon the exercise of each Warrant shall be
      determined by multiplying the number of Shares theretofore purchasable
      upon exercise of the Warrant by a fraction, of which the numerator shall
      be the number of shares of Common Stock outstanding immediately prior to
      the issuance of such rights, options, warrants or convertible securities
      plus the number of additional Common Stock offered for subscription or
      purchase, and of which the denominator shall be the number of shares of
      Common Stock outstanding immediately prior to the issuance of such rights,
      options, warrants or convertible securities plus the number of shares
      which the aggregate offering price of the total number of shares offered
      would purchase at such then effective Warrant Price. Such adjustment shall
      be made whenever such rights, options,

<PAGE>

      warrants or convertible securities are issued, and shall become effective
      immediately and retroactive to the record date for the determination of
      shareholders entitled to receive such rights, options, warrants or
      convertible securities, provided no such adjustment shall be made for
      rights issued in connection with what is customarily referred to as a
      "poison pill" or "shareholder rights plan."

            (c) In case the Company shall distribute to all or substantially all
      holders of its Common Stock evidences of its indebtedness or assets
      (excluding cash dividends or distributions out of earnings) or rights,
      options, warrants or convertible securities containing the right to
      subscribe for or purchase Shares (excluding those referred to in
      subsection 8.1(b) above and rights in connection with a shareholder rights
      plan), then in each case the number of Shares thereafter purchasable upon
      the exercise of the Warrants shall be determined by multiplying the number
      of Shares theretofore purchasable upon exercise of the Warrants by a
      fraction, of which the numerator shall be the then effective Warrant Price
      as of the date of such distribution calculated pursuant to this Section 8,
      and of which the denominator shall be such then effective Warrant Price on
      such date minus the then fair value (determined as provided in
      subparagraph (f) below) of the portion of the assets or evidences of
      indebtedness so distributed or of such subscription rights, options,
      warrants or convertible securities applicable to one share. Such
      adjustment shall be made whenever any such distribution is made and shall
      become effective on the date of distribution retroactive to the record
      date for the determination of shareholders entitled to receive such
      distribution.

            (d) No adjustment in the number of Shares purchasable pursuant to
      the Warrants shall be required unless such adjustment would require an
      increase or decrease of at least one percent in the number of Shares then
      purchasable upon the exercise of the Warrants or, if the Warrants are not
      then exercisable, the number of Shares purchasable upon the exercise of
      the Warrants on the first date thereafter that the Warrants become
      exercisable; provided that any adjustments which by reason of this
      subsection 8.1(d) are not required to be made immediately shall be carried
      forward and taken into account in any subsequent adjustment.

            (e) Whenever the number of Shares purchasable upon the exercise of a
      Warrant is adjusted, as herein provided, the Warrant Price payable upon
      exercise of such Warrant shall be adjusted by multiplying such Warrant
      Price immediately prior to such adjustment by a fraction, of which the
      numerator shall be the number of Shares purchasable upon the exercise of
      the Warrant immediately prior to such adjustment, and of which the
      denominator shall be the number of Shares so purchasable upon the exercise
      of the Warrant immediately thereafter.

            (f) Whenever the number of Shares purchasable upon the exercise of
      Warrants is adjusted as herein provided, the Company shall cause to be
      promptly mailed to the Warrantholders by first class mail, postage
      prepaid, notice of such adjustment and a certificate of the chief
      financial officer of the Company setting forth the number of Shares
      purchasable upon the exercise of the Warrants after

<PAGE>

      such adjustment, a brief statement of the facts requiring such adjustment
      and the computation by which such adjustment was made.

            (g) For the purpose of this subsection 8.1, the term Common Stock
      shall mean (i) the class of Common Stock designated as the Common Stock of
      the Company at the date of this Agreement, or (ii) any other class of
      shares resulting from successive changes or reclassification of such
      Common Stock consisting solely of changes in par value, or from par value
      to no par value, or from no par value to par value. In the event that at
      any time, as a result of an adjustment made pursuant to this Section 8, a
      Warrantholder shall become entitled to purchase any securities of the
      Company other than Common Stock, (i) if the Warrantholders' right to
      purchase is on any other basis than that available to all holders of the
      Common Stock, the Company shall obtain an opinion of an independent
      investment banking firm valuing such other securities and (ii) thereafter
      the number of such other securities so purchasable upon exercise of the
      Warrants shall be subject to adjustment from time to time in a manner and
      on terms as nearly equivalent as practicable to the provisions with
      respect to the Common Stock contained in this Section 8.

            (h) Upon the expiration of any rights, options, warrants or
      conversion privileges, if such shall not have been exercised, the number
      of Shares purchasable upon exercise of the Warrants, to the extent the
      Warrants have not then been exercised, shall, upon such expiration, be
      readjusted and shall thereafter be such as they would have been had they
      been originally adjusted (or had the original adjustment not been
      required, as the case may be) on the basis of (A) the fact that the only
      shares of Common Stock so issued were the shares of Common Stock, if any,
      actually issued or sold upon the exercise of such rights, options,
      warrants or conversion privileges, and (B) the fact that such shares of
      Common Stock, if any, were issued or sold for the consideration actually
      received by the Company upon such exercise plus the consideration, if any,
      actually received by the Company for the issuance, sale or grant of all
      such rights, options, warrants or conversion privileges whether or not
      exercised; provided, however, that no such readjustment shall have the
      effect of decreasing the number of Shares purchasable upon exercise of the
      Warrants by an amount in excess of the amount of the adjustment initially
      made in respect of the issuance, sale or grant of such rights, options,
      warrants or conversion privileges.

      8.2. NO ADJUSTMENT FOR DIVIDENDS. Except as provided in subsection 8.1, no
adjustment to the Warrants or any provision or condition thereof in respect of
any dividends or distributions out of earnings shall be made during the term of
the Warrants or upon the exercise of Warrants.

      8.3. NO ADJUSTMENT IN CERTAIN CASES. No adjustments to the Warrants or any
provision or condition thereof shall be made pursuant to Section 3 or Section 8
hereof in connection with (i) the issuance of Common Stock upon exercise of the
Warrants, (ii) the grant or exercise of the options to purchase Common Stock
under the Company's Stock Plans or any future option plan for the sole benefit
of the Company's employees,

<PAGE>

consultants and directors, or (iii) the issuance of securities in an equity
financing regardless of the offering price.

      8.4. PRESERVATION OF PURCHASE RIGHTS UPON RECLASSIFICATION, CONSOLIDATION,
ETC. In case of any consolidation of the Company with or merger of the Company
into another entity or in case of any sale or conveyance to another entity of
the property, assets or business of the Company as an entirety or substantially
as an entirety, the Company or such successor or purchasing entity, as the case
may be, shall execute with the Warrantholders an agreement that the
Warrantholders shall have the right thereafter, upon exercise of the Warrants
and payment of the Warrant Price in effect immediately prior to such
consolidation, merger or sale, to purchase the kind and amount of shares and
other securities and property which it would have been entitled to receive after
the happening of such consolidation, merger, sale or conveyance had the Warrants
been exercised immediately prior thereto. In the event of a merger described in
Section 368(a)(2)(E) of the Internal Revenue Code of 1986 (or any successor
provision), in which the Company is the surviving corporation, the right to
purchase Shares under the Warrants shall terminate on the date of such merger
and thereupon the Warrants shall become null and void, but only if the
controlling corporation (after such event) shall agree to substitute for the
Warrants its warrants entitling the holder thereof to purchase the kind and
amount of shares and other securities and property which it would have been
entitled to receive had the Warrants been exercised immediately prior to such
merger. Any such agreements referred to in this subsection 8.4 shall provide for
adjustments, which shall be as nearly equivalent as may be practicable to the
adjustments provided for in Section 8 hereof, and shall contain substantially
the same terms, conditions and provisions as are contained herein immediately
prior to such event. The provisions of this subsection 8.4 shall similarly apply
to successive consolidations, mergers, sales or conveyances.

      8.5. NOMINAL VALUE OF COMMON STOCK. Before taking any action which would
cause an adjustment effectively reducing the portion of the Warrant Price
allocable to each Share below the then nominal value per Share issuable upon
exercise of the Warrants, the Company will take any corporate action which may,
in the opinion of its counsel, be necessary in order that the Company may
validly and legally issue fully paid and nonassessable Shares upon exercise of
the Warrants.

      8.6. INDEPENDENT PUBLIC ACCOUNTANTS. The Company may retain a firm of
independent public accountants of recognized national standing in the United
States (which may be any such firm regularly employed by the Company) to make
any computation required under this Section 8, and a certificate signed by such
firm shall be evidence of the correctness of any computation made under this
Section 8.

      8.7. STATEMENT ON WARRANT CERTIFICATES. Irrespective of any adjustments in
the number of securities issuable upon exercise of Warrants, Warrant
certificates theretofore or thereafter issued may continue to express the same
number of securities as are stated in the similar Warrant certificates initially
issuable pursuant to this Agreement. However, the Company may, at any time in
its reasonable discretion, make any change in the form of Warrant certificate
that it may deem appropriate and that does not affect the substance thereof; and
any Warrant certificate hereafter issued, whether upon registration of transfer

<PAGE>

of, or in exchange or substitution for, an outstanding Warrant certificate, may
be in the form so changed.

      SECTION 9. FRACTIONAL INTERESTS; MARKET PRICE. The Company shall not be
required to issue fractional Shares upon the exercise of any Warrant. If any
fraction of a Share would, except for the provisions of this Section 9, be
issuable on the exercise of any Warrant (or specified portion thereof), the
Company shall pay an amount in cash equal to the Market Price multiplied by such
fraction. For all purposes of this Agreement, the term "MARKET PRICE" as of any
specified date shall mean (i) if the Common Stock is traded in the United States
over-the-counter market and not on the Nasdaq Stock Market or on any United
States national securities exchange, the average of the mean between the bid and
asked prices of the Common Stock on each of the five consecutive trading days
immediately preceding the date in question, as reported by the National
Quotation Bureau Incorporated or an equivalent generally accepted reporting
service, or (ii) if the Common Stock is traded on the Nasdaq Stock Market or on
one or more United States national securities exchanges, the average, for the
five consecutive trading days immediately preceding the date in question, of the
daily closing price of the Common Stock on the Nasdaq Stock Market or the daily
closing price for consolidated transactions on the principal United States
national securities exchange on which the Common Stock is listed, or (iii) if
the Common Stock is not traded in the United States over-the-counter market, the
Nasdaq Stock Market or any United States national securities exchange, the
average, for the five consecutive trading days immediately preceding the date in
question, of the daily closing price of the Common Stock on the principal
non-United States exchange on which the Common Stock is listed. The daily
closing price referred to in clauses (ii) and (iii) above shall be the last
reported sale price on the day in question or, if no reported sale takes place
on such day, the average of the reported closing bid and asked prices.

      SECTION 10. NO RIGHTS AS SHAREHOLDER; NOTICES TO WARRANTHOLDERS. Nothing
contained in this Agreement or in the Warrants shall be construed as conferring
upon the Warrantholder or any transferee of a Warrant any rights as a
shareholder of the Company, including (without limitation) the right to vote,
receive dividends, consent or receive notices as a shareholder in respect of any
meeting of shareholders for the election of directors of the Company or any
other matter. If, however, at any time prior to the expiration of the Warrants
and prior to their exercise in full, any one or more of the following events
shall occur:

            (a) any action which would require an adjustment pursuant to Section
      8.1 or 8.4; or

            (b) a dissolution, liquidation or winding up of the Company (other
      than in connection with a consolidation, merger or sale of its property,
      assets and business as an entirety or substantially as an entirety) shall
      be proposed;

then the Company shall give notice in writing of such event to each of the
Warrantholders, as provided in Section 14 hereof, at least 10 days prior to the
date fixed as a record date or the date of closing the transfer books for the
determination of the

<PAGE>

shareholders entitled to any relevant dividend, distribution, subscription
rights or other rights or for the determination of shareholders entitled to vote
on such proposed dissolution, liquidation or winding up. Such notice shall
specify such record date or the date of closing the transfer books, as the case
may be. Failure to mail or receive such notice or any defect therein shall not
affect the validity of any action taken with respect thereto.

      SECTION 11. RESTRICTIONS ON TRANSFER; REGISTRATION RIGHTS.

            (a) There shall be no transfer of Warrants except as permitted
pursuant to Section 1.3 hereof. If any Holder proposes to sell or otherwise
transfer any Shares, and if such Shares are not then registered for resale
pursuant to an effective registration statement under the Act, the Holder
proposing to make such transfer shall give written notice to the Company
describing briefly the manner in which any such proposed transfer is to be made;
and no such transfer shall be made unless the Company shall notify such Holder
that in the opinion of Company's counsel, registration under the Act is not
required with respect to such transfer.

            (b) If at any time during the period prior to the Termination Date
the Shares are not subject to an effective registration statement under the Act
(a "REGISTRATION STATEMENT"), the Company shall be obligated to the
Warrantholders and the registered holders of the Shares issued upon exercise of
the Warrants (collectively with the Warrantholders, the "HOLDERS"), as follows:

                  (i) Whenever during the period beginning on the Commencement
      Date and ending on the Termination Date, the Company proposes to file with
      the Securities and Exchange Commission (the "COMMISSION") a Registration
      Statement (other than a registration statement on Form S-8 (or other form)
      relating solely to securities issued pursuant to an employee benefit plan,
      or a registration statement on Form F-4 or S-4 or any successor form
      thereto), the Company shall, at least 20 days prior to each such proposed
      filing, give written notice thereof to the Holders at their respective
      addresses appearing on the records of the Company, and shall offer to
      include and shall include in such filing any Shares as to which written
      requests for such inclusion are received by the Company from Holders not
      more than 10 days after such Company's notice is mailed to the Holders.
      The Shares which are the subject of valid requests from Holders are
      hereinafter referred to as the "PIGGYBACK SHARES." If such registration
      statement relates in whole or in part to an underwritten public offering
      of the Common Stock by the Company, the right of any Holder to
      registration pursuant to this Section 11(b) shall be conditioned upon such
      Holder's participation in any underwriting of the Company's public
      offering. All Holders proposing to distribute their Piggyback Shares
      through such underwriting shall (together with the Company and other
      holders of Common Stock participating in such underwriting) enter into an
      underwriting agreement in customary form with the underwriter or
      underwriters selected for such underwriting by the Company. In addition,
      if, after the number of Piggyback Shares is

<PAGE>

      determined, the managing underwriter of such offering determines that
      marketing factors require a limitation on the number of shares of Common
      Stock to be underwritten other than those to be offered by the Company for
      its own account, the managing underwriter may exclude any or all of the
      Piggyback Shares from such registration statement and underwriting, but
      only to the extent that the Company excludes Common Stock which other
      shareholders of the Company have requested the Company to include in such
      registration statement and underwriting pursuant to "piggyback rights"
      similar to those granted in this Section 11(b) (such other Common Stock
      which is the subject of such requests are hereinafter referred to as
      "OTHER PIGGYBACK SHARES"). In the event that any Piggyback Shares are so
      excluded, the number of Piggyback Shares and Other Piggyback Shares that
      shall be included in such registration statement and underwriting shall be
      allocated equally among all Holders and the holders of Other Piggyback
      Shares in proportion, as nearly as practicable, to the total number of
      Piggyback Shares and Other Piggyback Shares.

                  (c) In connection with any Registration Statement filed
pursuant to paragraph (b) of this Section 11, the Company shall take such action
as may be necessary or appropriate to comply with the securities or blue sky
laws of such states of the United States as shall reasonably be requested by the
Holders, and shall do any and all other acts which may be necessary or advisable
to permit the proposed sale or other disposition of the Shares in any such
state; provided that in no event shall the Company be obligated in connection
therewith to qualify as a foreign corporation or as a dealer in any jurisdiction
where it is not already so qualified, or to execute a general consent for
service of process in suits other than those arising out of the offer and sale
of the Shares, or to take any action which would subject it to taxation in any
jurisdiction where it is not then so subject.

                  (d) The Company's obligations under paragraph (b) of this
Section 11 with respect to any Holder shall be conditioned in each instance upon
the timely receipt by the Company in writing of (i) information from such Holder
as to the proposed plan of distribution of such Holder's Shares to be included
in a Registration Statement, and (ii) such other information as may be required
by law from such holder, or its underwriter or other agent, for inclusion in
such Registration Statement.

                  (e) Each Holder will not make any sale of the Shares, pursuant
to the Registration Statement referred to in this Section 11 without effectively
causing the prospectus delivery requirements under the Act to be satisfied. Each
Holder acknowledges that there may occasionally be times when the Company must
suspend the use of the prospectus forming a part of the Registration Statement
until such time as an amendment to such registration statement has been field by
the Company and declared effective by the Commission or until the Company has
amended or supplemented such prospectus. The Company will use its best efforts
to cause such amended registration statement to be declared effective and/or to
deliver such amended or supplemented prospectus as soon as possible. Each Holder
hereby covenants that it will not sell any Shares pursuant to said prospectus
without first confirming with the Company that the Registration Statement has
not been suspended, and during the period commencing at the

<PAGE>

time at which the Company gives the Holder notice of the suspension of the use
of said prospectus and ending at the time the Company gives the Holder notice
that the Holder may thereafter effect sales pursuant to said prospectus.

                  (f) The Company shall pay all fees, disbursements and
out-of-pocket expenses (other than any Holder's brokerage fees and commissions
and legal fees) payable in connection with (i) any Registration Statement filed
under Section 11(b), and (ii) compliance with applicable state securities and
blue sky laws. In connection with registrations pursuant to Section 11(b) (i)
hereof, each Holder shall also pay its pro-rata portion of any filing fee
required by the Securities and Exchange Commission. The Company at its expense
will supply the Holders of Shares included in a Registration Statement with
copies of such Registration Statement and the prospectus included therein and
other related documents and opinions and no-action letters, in such quantities
as may be reasonably requested by such Holders. In connection with each
Registration Statement, the Company shall furnish to Holders of Shares included
therein such opinions of counsel, comfort letters of accountants, certificates
and other documents that are customary in connection with underwritten public
offerings and that are reasonably requested by such Holders.

                  (g) The Company shall not be required by this Section 11 to
include or maintain in any Registration Statement any Shares which, in the
opinion of counsel for the Company, could be sold pursuant to Rule 144 under the
Act in any three-month period without volume limitation.

      SECTION 12. INDEMNIFICATION.

                  (a) In the event that any Registration Statement is filed
pursuant to Section 11 hereof, the Company will indemnify and hold harmless each
Holder identified as a selling security holder therein, and each person, if any,
who controls such Holder within the meaning of the Act, against any and all
losses, claims, damages or liabilities, joint or several (including any
reasonable investigation, legal and other expenses incurred in connection with,
and any amount paid in settlement of, any action, suit or proceeding or any
claim asserted), to which they or any of them may become subject under the Act,
the Securities Exchange Act of 1934, as amended (the "EXCHANGE ACT") or other
federal or state law or regulation, at common law or otherwise, insofar as such
losses, claims, damages or liabilities (or actions in respect thereof) arise out
of or are based upon (i) any untrue statement or alleged untrue statement of a
material fact contained in any such Registration Statement, any related
preliminary prospectus, final prospectus, or amendment thereof or supplement
thereto, or any related blue sky filing, or (ii) the omission or alleged
omission to state therein a material fact required to be stated therein or
necessary to make the statements therein, in light of the circumstances under
which they were made, not misleading; provided that the Company shall not be
liable under this Section 12(a) in any such case to the extent that any such
losses, claims, damages or liabilities arise solely out of or are based upon an
untrue statement of a material fact contained in, or any omission of a material
fact from, such Registration Statement, preliminary prospectus, final prospectus
or amendment thereof or supplement thereto in reliance upon, and in conformity
with, information furnished in writing to the Company by such Holder
specifically for use therein, provided further, that the indemnification

<PAGE>

contained in this Section 12(a) with respect to any prospectus after is has been
amended or supplemented, shall not inure to the benefit of any Holder from whom
the person asserting such loss, claim, damage, or liability shall have purchased
Shares, that are the subject thereof if, after copies thereof have been
delivered by the Company to such Holder, such Holder shall have failed to send
or give a copy of the prospectus as then amended or supplemented, as the case
may be, to such person at or prior to the confirmation of such sale of such
Shares, to such person, and if such loss, claim, damage or liability would not
have arisen but for the failure of such Holder to deliver the same. This
indemnity will be in addition to any liability which the Company may otherwise
have.

                  (b) Each Holder who is identified as a selling security holder
in a filed Registration Statement will severally, and not jointly, indemnify and
hold harmless the Company, each other person referred to in subparts (1), (2)
and (3) of Section 11(a) of the Act in respect of the Registration Statement,
and each person, if any, who controls the Company or any such person within the
meaning of Section 15 of the Act, against any and all losses, claims, damages or
liabilities (including any reasonable investigation, legal and other expenses
incurred in connection with, and any amount paid in settlement of, any action,
suit or proceeding or any claim asserted), to which they, or any of them, may
become subject under the Act, the Exchange Act or other federal or state law or
regulation, at common law, or otherwise, insofar as such losses, claims, damages
or liabilities (or actions in respect thereof) arise out of or are based upon
(i) any untrue statement or alleged untrue statement of a material fact
contained in such Registration Statement, any related preliminary prospectus,
final prospectus or amendment thereof or supplement thereto, or any related blue
sky filing, or (ii) the omission or alleged omission to state therein a material
fact required to be stated therein or necessary to make the statements therein,
in light of the circumstances under which they were made, not misleading, in
each case to the extent, but only to the extent, that such untrue statement or
omission was made in such Registration Statement, preliminary prospectus, final
prospectus or amendment thereof or supplement thereto in reliance upon, and in
conformity with, information furnished in writing to the Company by such Holder
specifically for use therein. This indemnity will be in addition to any
liability which a Holder may otherwise have to the Company.

                  (c) Any party that proposes to assert the right to be
indemnified under this Section 12 shall, promptly after receipt of notice of the
commencement of any action, suit or proceeding against such party in respect of
which a claim is to be made against an indemnifying party or parties under this
Section, notify each such indemnifying party of the commencement thereof,
enclosing a copy of all papers served. No indemnification provided for in
Section 12(a) or 12(b) shall be available to any party who shall fail to give
notice as provided in this Section 12(c) if the party to whom notice was not
given was unaware of the proceeding to which such notice would have related and
was materially prejudiced by the failure to give such notice, but the omission
so to notify such indemnifying party of any such action, suit or proceeding
shall not relieve it from any liability that it may have to any indemnified
party otherwise than under this Section 12 or Section 13. In case any such
action, suit or proceeding is brought against any indemnified party and it
notifies the indemnifying party of the commencement thereof, such indemnifying
party will be entitled to participate in, and, to

<PAGE>

the extent that it may wish, jointly with any other indemnifying party similarly
notified, to assume the defense thereof with counsel reasonably satisfactory to
such indemnified party, and, after notice from the indemnifying party to such
indemnified party of its election so to assume the defense thereof and the
approval by the indemnified party of such counsel (which approval shall not
unreasonably be withheld), the indemnifying party shall not be liable to such
indemnified party for any legal or other expenses, except as provided below and
except for the reasonable costs of investigation subsequently incurred by such
indemnified party in connection with the defense thereof. The indemnified party
shall have the right to employ its own counsel in any such action, suit or
proceeding but the fees and expenses of such counsel shall be at the expense of
such indemnified party unless (i) the employment of counsel by such indemnified
party has been authorized in writing by the indemnifying parties, (ii) the
indemnified party shall have reasonably concluded that there may be differing or
additional defenses available to it and not to one or more of the indemnifying
parties in such action, suit or proceeding (in which case the indemnifying
parties shall not have the right to direct the defense of such action, suit or
proceeding on behalf of the indemnified party), or (iii) the indemnifying
parties shall not have employed counsel to assume the defense of such action
within a reasonable time after notice of the commencement thereof, in each of
which cases the fees and expenses of the indemnified party's counsel shall be at
the expense of the indemnifying parties; however, the indemnifying party shall
not, in connection with any one such action, suit or proceeding or separate but
substantially similar or related actions, suits or proceedings in the same
jurisdiction arising out of the same general allegations or circumstances, be
liable for the reasonable fees and expenses of more than one separate firm of
attorneys for the Holders and controlling persons, which firm shall be
designated in writing by a majority in interest of such Holders and controlling
persons (based upon the value of the Shares included in the Registration
Statement). An indemnifying party shall not be liable for any settlement of any
action, suit, proceeding or claim effected without its written consent.

      SECTION 13. CONTRIBUTION. In order to provide for just and equitable
contribution in circumstances in which the indemnification provided for in
Section 12 is due in accordance with its terms but for any reason is held to be
unavailable or insufficient to hold harmless an indemnified party, the Company
(including for this purpose any controlling person of the Company, any director
of the Company and any officer of the Company who signed the Registration
Statement) on the one hand, and the Holders (including for this purpose any
controlling persons thereof) on the other hand, shall, in lieu of indemnifying
such indemnified party, contribute to the aggregate losses, claims, damages or
liabilities referred to in Section 12 above (including any investigation, legal
and other expenses reasonably incurred in connection with, and any amount paid
in settlement of, any action, suit or proceeding or any claims asserted, but
after deducting any contribution received by or payable to the Company from
other persons other than the Holders, such as other selling securityholders,
persons who control the Company within the meaning of the Act, officers of the
Company who signed the Registration Statement, and directors of the Company),
(a) in such proportion as is appropriate to reflect the relative benefits
received by the Company and the Holders from the offering or offerings covered
by the Registration Statement or, (b) if the allocation provided by clause (a)
above is not permitted by applicable law, in such proportion as is appropriate
to

<PAGE>

reflect not only the relative benefits referred to in clause (a) above but also
the relative fault of the Company and the Holders in connection with the
statements or omissions which resulted in such losses, claims, damages,
liabilities or expenses, as well as any other relevant equitable considerations.
The relative benefits received by the Company on the one hand and any Holder on
the other hand shall be deemed to be in the same proportion as (x) the total
proceeds (if any) received by the Company from the offering or offerings covered
by the Registration Statement (net of underwriting discounts but before
deducting expenses, if applicable), plus all cash proceeds received by the
Company from the exercise of the Warrants for the Shares of such Holder included
in the Registration Statement, bear to (y) the total proceeds received by such
Holder from the sale of Shares included in the Registration Statement. The
relative fault of the Company and any Holder shall be determined by reference
to, among other things, whether the untrue or alleged untrue statement of a
material fact or omission related to information supplied by the Company or such
Holder, and their relative intent, knowledge, access to information and
opportunity to correct or prevent such statement or omission. The Company,
Sunrise, and the Holders agree that it would not be just and equitable if
contribution pursuant to this Section 13 were determined by pro rata allocation
(even if the Holders were treated as one entity for such purpose) or by any
other method of allocation which does not take account of the equitable
considerations referred to above. Notwithstanding the provisions of this Section
13, in no case shall any Holder (except as may be provided by agreement among
them) be liable or responsible for any amount in excess of the proceeds received
by such Holder from the sale of the Shares included in the Registration
Statement; provided that no person guilty of fraudulent misrepresentation
(within the meaning of Section 11(f) of the Act) shall be entitled to
contribution from any person who was not guilty of such fraudulent
misrepresentation. For purposes of this Section 13, each person, if any, who
controls a Holder within the meaning of Section 15 of the Act or Section 20(a)
of the Exchange Act shall have the same rights to contribution as such Holder,
and each person, if any, who controls the Company within the meaning of the
Section 15 of the Act or Section 20(a) of the Exchange Act, each director of the
Company and each officer of the Company who shall have signed the Registration
Statement, shall have the same rights to contribution as the Company, subject in
each case to clauses (i) and (ii) in the immediately preceding sentence of this
Section 13. Any party entitled to contribution will, promptly after receipt of
notice of commencement of any action, suit or proceeding against such party in
respect of which a claim for contribution may be made against another party or
parties under this Section 13, notify such party or parties from whom
contribution may be sought, and the omission so to notify such party or parties
from whom contribution may be sought shall relieve the party or parties from
whom contribution may be sought (if such party was unaware of such action, suit
or proceeding and was materially prejudiced by such omission) from any liability
under this Section 13, but not from any other obligation it or they may have
hereunder or otherwise than under this Section 13. No party shall be liable for
contribution with respect to any settlement of an action, suit, proceeding or
claim effected without its written consent. The obligations of the Holders to
contribute pursuant to this Section 13 are several in proportion to their
respective number of Shares included in the Registration Statement, and not
joint.

      SECTION 14. NOTICES. Any notice pursuant to this Agreement shall be in
writing and shall be deemed to have been duly given (i) if given by facsimile
transmission on the

<PAGE>

business day on which such transmission is sent and confirmed, (ii) if given by
air courier, two business days following the date it was sent or (iii) if mailed
by certified mail, return receipt requested, ten business days following the
date it was mailed, to the following addresses (unless another address is herein
specified):

            (a) If to a Holder, addressed to: Sunrise Securities Corp., 135 East
      57th Street, 11th Floor, New York, New York 10022, Attention: Mr. Derek
      Caldwell (fax: 212-421-5924), with a copy to Mintz, Levin, Cohn, Ferris,
      Glovsky and Popeo, P.C., Chrysler Center, 666 Third Avenue, New York, New
      York 10017. Attention Todd Mason, Esq. (Fax: (212) 983-3115).

            (b) If to the Company, addressed to: 330 Nevada Street, Newton,
      Massachusetts 02160, Attention: Chief Executive Officer (fax:
      617-928-0821) with a copy to: Testa, Hurwitz & Thibeault, LLP, 125 High
      Street, Boston, Massachusetts 02110, Attention: Rufus C. King, Esq. (fax:
      617-248-7100)

      Each party may from time to time change the address or fax number to which
notices to it are to be delivered or mailed hereunder by notice in accordance
herewith to the other party.

      SECTION 15. SUCCESSORS. All the covenants and provisions of this Agreement
by or for the benefit of the Company, Sunrise and the Holders shall bind and
inure to the benefit of their respective successors and assigns.

      SECTION 16. MERGER OR CONSOLIDATION OF THE COMPANY. The Company shall not
merge or consolidate with or into any other corporation or sell all or
substantially all of its property to another corporation, unless the provisions
of Section 8.4 are complied with.

      SECTION 17. APPLICABLE LAW; SUBMISSION TO JURISDICTION. THIS AGREEMENT
SHALL BE DEEMED TO BE A CONTRACT MADE UNDER THE LAWS OF THE COMMONWEALTH OF
MASSACHUSETTS AND FOR ALL PURPOSES SHALL BE CONSTRUED IN ACCORDANCE WITH THE
INTERNAL LAWS OF SAID STATE (WITHOUT REFERENCE TO ITS RULES AS TO CONFLICTS OF
LAWS). The Company and the Holders hereby agree to the exclusive jurisdiction of
the courts of the Commonwealth of Massachusetts or the federal courts sitting in
the Commonwealth of Massachusetts in connection with any action arising out of
this Agreement.

      SECTION 18. BENEFITS OF THIS AGREEMENT. Nothing in this Agreement shall be
construed to give to any person or corporation other than the Company, the
Warrantholders and holders of Shares any legal or equitable right, remedy or
claim under this Agreement. This Agreement shall be for the sole and exclusive
benefit of the Company and the Holders.

<PAGE>

      SECTION 19. AMENDMENT AND WAIVER. This Agreement and the Warrants may only
be amended, or any term hereof waived, in writing signed by the Company and
Warrantholders holding a majority of the Shares issued or issuable upon exercise
of the Warrants, whether or not an individual Warrantholder consents thereto.

                     [REST OF PAGE INTENTIONALLY LEFT BLANK]

<PAGE>

      IN WITNESS WHEREOF, the parties have caused this Placement Agent Warrant
Agreement to be duly executed, all as of the date and year first above written.

                                 MATRITECH, INC.

                                 By:
                                     ------------------------------------------
                                     Name:
                                     Title:

                                 SUNRISE SECURITIES CORP.

                                 By:
                                     ------------------------------------------
                                     Name:
                                     Title:

<PAGE>

            "THE WARRANTS REPRESENTED BY THIS CERTIFICATE, AND THE SECURITIES
            ISSUABLE UPON EXERCISE OF SUCH WARRANTS, HAVE NOT BEEN REGISTERED
            UNDER THE UNITED STATES SECURITIES ACT OF 1933 OR THE SECURITIES
            LAWS OF ANY STATE OF THE UNITED STATES. SUCH WARRANTS AND SECURITIES
            MAY NOT BE SOLD, ASSIGNED, EXCHANGED, HYPOTHECATED OR OTHERWISE
            TRANSFERRED IN ANY MANNER EXCEPT IN COMPLIANCE WITH SECTION 11 OF
            THE PLACEMENT AGENT WARRANT AGREEMENT BY AND BETWEEN THE ISSUER AND
            SUNRISE SECURITIES CORP. DATED MARCH 4, 2002."

                                                   WARRANT CERTIFICATE NO. PAW-2

                                 MATRITECH, INC.

                            (ORGANIZED UNDER THE LAWS
                            OF THE STATE OF DELAWARE)

                        WARRANTS TO PURCHASE COMMON STOCK

      This certifies that, for value received, SUNRISE SECURITIES CORP. (the
"WARRANTHOLDER") is the registered owner of 40,950 warrants (the "WARRANTS") to
purchase from Matritech, Inc. (the "COMPANY"), at any time during the period
commencing at 9:00 a.m., Eastern Time, on March 4, 2002 and ending at 5:00 p.m.,
Eastern Time, on March 4, 2005, exercisable at $2.81 per share (the "WARRANT
PRICE"), up to 40,950 shares of Common Stock. The Warrants are subject to, and
each Warrantholder, by acceptance of this certificate, consents to all the terms
and provisions of the Placement Agent Warrant Agreement dated as of March 4,
2002, between the Company and the Warrantholder, pursuant to which the Warrants
evidenced hereby were issued (the "WARRANT AGREEMENT").

      The Warrants evidenced hereby may be exercised in whole or in part by
presentation of this Warrant Certificate with the Purchase Form herein duly
executed (with a signature guarantee as provided therein), and simultaneous
payment of the Warrant Price for each Warrant exercised, at the principal office
of the Company. Payment of such price shall be made at the option of each
Warrantholder in cash or by certified or cashier's check, in next day funds.

      Upon any partial exercise of the Warrants evidenced hereby, there shall be
signed and issued to the Warrantholder effecting such partial exercise a new
Warrant Certificate

<PAGE>

in respect of the Common Stock as to which the Warrants evidenced hereby shall
not have been exercised. These Warrants may be exchanged at the office of the
Company by surrender of this Warrant Certificate properly endorsed for one or
more new Warrants of the same aggregate number of shares of Common Stock as here
evidenced by the Warrant or Warrants exchanged. No fractional shares of Common
Stock will be issued upon the exercise of rights to purchase hereunder, but the
Company shall pay the cash value of any fraction upon the exercise of one or
more Warrants. These Warrants are transferable at the office of the Company in
the manner and subject to the limitations set forth in the Warrant Agreement.

      This Warrant Certificate does not entitle any Warrantholder to any of the
rights of a shareholder of the Company.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

<PAGE>

MATRITECH, INC.

By:
   -----------------------------------
   Name:  Stephen D. Chubb
   Title:    Chief Executive Officer

ATTEST:

--------------------------------------

Title:
      --------------------------------

Dated: March 4, 2002

<PAGE>

                                  PURCHASE FORM

Matritech, Inc.
330 Nevada Street
Newton, Massachusetts 02160

      Pursuant to paragraph 3(a) of the Warrant Agreement, the undersigned
hereby irrevocably elects to exercise the right of purchase represented by this
Warrant Certificate for, and to purchase thereunder, __________ shares of Common
Stock ("Common Stock") provided for therein, and requests that certificates for
such Common Stock be issued in the name of:

                       -----------------------------------
  (Please Print or Type Name(s), Address and Taxpayer Identification Number(s))

                       -----------------------------------

                       -----------------------------------

                       -----------------------------------

If this Warrant Certificate is hereby being exercised with respect to fewer than
all the Common Stock specified herein, please issue a new Warrant Certificate
for the unexercised balance of the Warrants, registered in the name of the
undersigned Warrantholder or his assignee as below indicated and delivered to
the address stated below.

Dated:
       ---------------------------------

Name of Warrantholder(s)
    or Assignee(s) (Please Print):
                                   ---------------------------------

                                   ---------------------------------

Address (Please Print):
                        --------------------------------------------

                        --------------------------------------------

Signature(s):
              ------------------------------------------------------

              ------------------------------------------------------

            Note: The above signature(s) must correspond exactly with the
      name(s) as written upon the face of this Warrant Certificate, without
      alteration or enlargement or any change whatever, unless the Warrants have
      been assigned.

                                   ASSIGNMENT
                (To be signed only upon assignment of Warrants)

<PAGE>

      FOR VALUE RECEIVED, the undersigned hereby sells, assigns and transfers
unto

                       -----------------------------------

                       -----------------------------------

                       -----------------------------------

     (Name(s) and Address(es) of Assignee(s) Must be Printed or Typewritten)

the within Warrants, hereby irrevocably constituting and appointing
________________________ the undersigned's attorney-in-fact to transfer said
Warrants on the books of the Company, with full power of substitution.

Dated:
       ------------     ---------------------------------

                       -----------------------------------
                       Signature(s) of Registered Holder(s)

            Note: The above signature(s) must correspond exactly with the
      name(s) as written upon the face of this Warrant Certificate, without
      alteration or enlargement or any change whatever.

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