Document:

<PAGE>

                                                                  Exhibit 10.10
                                                                  -------------

                             EMPLOYMENT AGREEMENT

This Employment Agreement is entered into as of September 29, 2000, between
Phillip Michael Formica ("Employee") and OraSure Technologies, Inc., a Delaware
corporation (the "Company").

          1.   SERVICES.

              1.1  Employment. The Company agrees to employ Employee as Vice
President of Operations of the Company, and Employee hereby accepts such
employment in accordance with the terms and conditions of this Agreement.

              1.2  Duties. Employee shall have the position named in Section 1.1
with such powers and duties appropriate to that office (a) as may be provided by
the bylaws of the Company, (b) as otherwise set forth in Exhibit A attached to
this Agreement, and (c) as determined by the board of directors from time to
time. Subject to the provisions of Section 6.4 hereof, Employee's position and
duties may be changed from time to time during the term of this Agreement.
Employee's place of work shall be the Company's headquarters, at its present
location or as it may be relocated.

              1.3  Outside Activities. Employee shall obtain the consent of the
board of directors before he engages, either directly or indirectly, in any
other professional or business activities that may require an appreciable
portion of Employee's time or effort to the detriment of the Company's business.

              1.4  Direction of Services. Employee shall at all times discharge
his duties in consultation with and under the supervision and direction of the
Chief Operating Officer of the Company or such other person as the Chief
Executive Officer or board of directors may designate.

          2.  Term. The initial term of this Agreement shall begin as of the
date first written above and end on the second anniversary of that date, unless
sooner terminated in accordance with Section 6 below. Thereafter, this
Agreement shall automatically renew from year to year for successive one-year
terms (a) unless either party gives the other party written notice of that
party's intent not to renew this Agreement at least 180 days before the
expiration of its current term or (b) the Agreement is terminated in accordance
with Section 6 below.

         3.   COMPENSATION AND EXPENSES.

              3.1  Salary.  As compensation for services under this Agreement,
the Company shall pay to Employee a regular salary of $12,500 per month.
Subject to the provisions of Section 6.4 hereof, such salary may be adjusted
from time to time in the discretion of the board of directors. Payment shall be
made on a bi-weekly basis, less all amounts required by law or authorized by
Employee to be withheld or deducted.

                                     -1-
<PAGE>

              3.2  Bonus. The Company shall establish an executive bonus plan,
on such terms as may be approved by the board of directors or its executive
compensation committee. In addition to the salary described in Section 3.1
above, Employee shall be entitled to participate in the executive bonus plan.

              3.3  Long-Term Incentive. To the extent otherwise eligible,
Employee shall be entitled to participate in accordance with the terms of the
plan in any long-term incentive plan that may from time to time be adopted by
the board of directors or its executive compensation committee, in its sole
discretion.

              3.4  Additional Employee Benefits. To the extent otherwise
eligible, Employee shall be entitled to receive or participate in any
additional benefits, including without limitation medical and dental insurance
programs, profit sharing or pension plans, and medical reimbursement plans,
which may from time to time be made available by the Company to corporate
officers. The Company may change or discontinue such benefits at any time in
its sole discretion.

              3.5  Expenses. The Company shall reimburse Employee for all
reasonable and necessary expenses incurred in carrying out his duties under
this Agreement, subject to compliance with the Company's reasonable policies
relating to expense reimbursement.

              3.6  Fees. All compensation earned by Employee, other than
pursuant to this Agreement, as a result of services performed on behalf of the
Company or as a result of or arising out of any work done by Employee in any
way related to the scientific or business activities of the Company shall
belong to the Company. Employee shall pay or deliver such compensation to the
Company promptly upon receipt. For the purposes of this provision,
"compensation" shall include, but is not limited to, all professional and
nonprofessional fees, lecture fees, expert testimony fees, publishing fees,
royalties, and any related income, earnings, or other things of value; and
"scientific or business activities of the Company" shall include, but not be
limited to, any project or projects in which the Company is involved and any
subject matter that is directly or indirectly researched, tested, developed,
promoted, or marketed by the Company.

         4.   Stock Options. Employee shall be entitled to participate in the
Company stock option plan. The number of stock options that are granted to
Employee under the plan shall be determined by the board of directors or its
executive compensation committee.

         5.   Business Protection Agreement. In consideration of the stock
option grant described in Section 4, and other good and valuable consideration,
Employee and the Company are concurrently entering a Business Protection
Agreement. Employee's compliance with the terms of the Business Protection
Agreement, including without limitation the noncompetition provisions of the
Business Protection Agreement, is a material requirement of this Agreement.
Employee acknowledges that employment on the terms stated in this Agreement
constitutes a bona fide advancement.

                                     -2-
<PAGE>

         6.  TERMINATION.

              6.1  Termination Upon Death. This Agreement shall terminate
immediately upon Employee's death.

              6.2  Termination by Employee. Employee may terminate his
employment under this Agreement by 60 days' written notice to the Company.

              6.3  Termination by the Company for Cause. Employee's employment
under this Agreement may be terminated by the Company at any time for cause.
Only the following actions, failures, or events by or affecting Employee shall
constitute "cause" for termination of Employee by the Company: (i) willful and
continued failure by Employee to substantially perform his duties provided
herein after a written demand for substantial performance is delivered to
Employee by the chairman of the board of the Company, which demand identifies
with reasonable specificity the manner in which Employee has not substantially
performed his duties, and Employee's failure to comply with such demand within
a reasonable time; (ii) the engaging by Employee in gross misconduct or gross
negligence materially injurious to the Company; (iii) the commission of any act
in direct competition with or materially detrimental to the best interests of
the Company; or (iv) Employee's conviction of having committed a felony.
Notwithstanding the foregoing, Employee shall not be deemed to have been
terminated by the Company for cause unless and until there shall have been
delivered to him a copy of a resolution duly adopted by the affirmative vote of
not less than a majority of the entire membership of the board of directors of
the Company finding that, in the good faith opinion of the board of directors,
the Company has cause for the termination of the employment of Employee as set
forth in any of clauses (i) through (iv) above and specifying the particulars
thereof in reasonable detail. The findings of the board of directors shall not
be binding on the arbitrators or other finders of fact in connection with any
litigation or dispute arising out of this Agreement.

              6.4  Termination by the Company Without Cause. The Company may
terminate Employee's employment under this Agreement without cause by written
notice to Employee. Employee may (but shall not be required to) elect to treat
any of the following events as a termination without cause, provided Employee
acts within 60 days of the event:

                   6.4.1  A material breach of this Agreement by the Company and
a failure by the Company to cure the breach within 30 days after Employee has
given written notice of the breach to the board of directors.

                   6.4.2  A reduction in Employee's salary below the amount
stated in Section 3.1 (except as part of and in proportion to a reduction in
all executive officers' salaries) or a change in Employee's title or a
substantial diminution in Employee's duties below those stated in this
Agreement.

                   6.4.3  A "Change of Control" of the Company. For purposes of
this Agreement, a "Change of Control" shall mean a change of control of a
nature that would be required to be reported in response to Item 6(e) of
Schedule 14A of Regulation 14A as in effect on the date hereof pursuant to the
Securities Exchange Act of 1934 (the "Exchange Act");

                                     -3-
<PAGE>

provided that, without limitation, such a change of control shall be deemed to
have occurred at such time as (i) any Acquiring Person hereafter becomes the
"beneficial owner" (as defined in Rule 13d-3 under the Exchange Act), directly
or indirectly, of 30 percent or more of the combined voting power of Voting
Securities; (ii) during any period of 12 consecutive calendar months,
individuals who at the beginning of such period constitute the board of
directors cease for any reason to constitute at least a majority thereof unless
the election, or the nomination for election, by the Company's shareholders of
each new director was approved by a vote of at least a majority of the
directors then still in office who were directors at the beginning of the
period; (iii) there shall be consummated (a) any consolidation or merger of the
Company in which the Company is not the continuing or surviving corporation or
pursuant to which Voting Securities would be converted into cash, securities,
or other property, other than a merger of the Company in which the holders of
Voting Securities immediately prior to the merger have the same, or
substantially the same, proportionate ownership of common stock of the
surviving corporation immediately after the merger, or (b) any sale, lease,
exchange, or other transfer (in one transaction or a series of related
transactions) of all, or substantially all, of the assets of the Company; or
(iv) approval by the shareholders of the Company of any plan or proposal for
the liquidation or dissolution of the Company. For purposes of this Agreement,
"Acquiring Person" means any person or related persons which constitute a
"group" for purposes of Section 13(d) and Rule 13d-5 under the Exchange Act, as
such Section and Rule are in effect as of the date of this Agreement; provided,
however, that the term Acquiring Person shall not include: (i) the Company or
any of its subsidiaries; (ii) any employee benefit plan of the Company or any
of its subsidiaries; (iii) any entity holding voting capital stock of the
Company for or pursuant to the terms of any such employee benefit plan; or (iv)
any person or group solely because such person or group has voting power with
respect to capital stock of the Company arising from a revocable proxy or
consent given in response to a public proxy or consent solicitation made
pursuant to the Exchange Act. For purposes of this Agreement, "Voting
Securities" means the Company's issued and outstanding securities ordinarily
having the right to vote at elections for the Company's board of directors.

              6.5  Compensation Upon Termination.

                   6.5.1  Termination Under Sections 6.1, 6.2, or 6.3. In the
event of a termination of Employee's employment under Sections 6.1, 6.2, or
6.3, Employee's regular compensation pursuant to Section 3.1 shall be prorated
and payable until the date of termination and Employee shall be paid any bonus
that has been approved but not yet paid.

                   6.5.2  Termination Under Section 6.4. In the event of a
termination of Employee's employment by the Company without cause as provided
in Section 6.4, Employee shall continue to be paid the salary provided in
Section 3.1 for the greater of (a) 12 months, (b) the remaining term of this
Agreement, or (c) 24 months if Employee elects to treat an event described in
Section 6.4.3 as a termination without cause, from the date of notice of such
termination of employment or the date of such event, in the manner and at the
times at which regular compensation was paid to Employee during the term of his
employment under this Agreement, except that if Employee elects to treat an
event described in Sections 6.4.1, 6.4.2, or 6.4.3 as a termination without
cause but continues to work for the Company or any of its subsidiaries, then
any amounts Employee receives as compensation following the event shall be
credited against the amounts payable to Employee under this section. In no
other respect

                                     -4-
<PAGE>

shall the amount of any payment provided for in this section be reduced by any
compensation or benefits earned by employee as a result of employment after his
termination. As a condition to receipt of the compensation described in the
first sentence of this Section 6.5.2, Employee shall sign and deliver a release
agreement, in form and substance satisfactory to the Company and Employee,
releasing all claims related to Employee's employment. The Company's obligation
to pay the amounts stated in this section shall terminate if Employee fails to
comply with the Business Protection Agreement within the applicable time period
stated in the first sentence of this section.

         7.   Remedies. The respective rights and duties of the Company and
Employee under this Agreement are in addition to, and not in lieu of, those
rights and duties afforded to and imposed upon them by law or at equity.

         8.   Severability of Provisions. The provisions of this Agreement are
severable, and if any provision hereof is held invalid or unenforceable, it
shall be enforced to the maximum extent permissible, and the remaining
provisions of the Agreement shall continue in full force and effect.

         9.   Nonwaiver. Failure by either party at any time to require
performance of any provision of this Agreement shall not limit the right of the
party failing to require performance to enforce the provision. No provision of
this Agreement may be waived by either party except by a writing signed by that
party. A waiver of any breach of a provision of this Agreement shall be
construed narrowly and shall not be deemed to be a waiver of any succeeding
breach of that provision or a waiver of that provision itself or of any other
provision.

         10.  Arbitration.

              10.1 Claims Covered. All claims or controversies, except for
those excluded by Section 10.2 ("claims"), whether or not arising out of
Employee's employment (or its termination), that the Company may have against
the Employee or that Employee may have against the Company or against its
officers, directors, employees or agents, in their capacity as such or
otherwise, shall be resolved as provided in this Section 10. Claims covered by
this Section 10 include, but are not limited to, claims for wages or other
compensation due; claims for breach of any contract or covenant (express or
implied); tort claims; claims for discrimination (including, but not limited
to, race, sex, sexual orientation, religion, national origin, age, marital
status, or disability); claims for benefits (except where an employee benefit
or pension plan specifies that its claims procedure shall culminate in an
arbitration procedure different from this one), and claims for violation of any
federal, state, or other governmental law, statute, regulation, or ordinance,
except as provided in Section 10.2.

              10.2 Non-Covered Claims. Claims arising out of the Business
Protection Agreement and workers' compensation or unemployment compensation
benefits are not covered by this Section 10. Non-covered claims include but are
not limited to claims by the Company for injunctive and/or other equitable
relief for unfair competition and/or the use and/or unauthorized disclosure of
trade secrets or confidential information, as to which Employee understands and
agrees that the Company may seek and obtain relief from a court of competent
jurisdiction.

                                     -5-
<PAGE>

              10.3 Required Notice of All Claims and Statute of Limitations.
Company and Employee agree that the aggrieved party must give written notice of
any claim to the other party within one year of the date the aggrieved party
first has knowledge of the event giving rise to the claim; otherwise the claim
shall be void and deemed waived even if there is a federal or state statute of
limitations which would have given more time to pursue the claim. The written
notice shall identify and describe the nature of all claims asserted and the
facts upon which such claims are based.

              10.4 Arbitration Procedures. Any arbitration shall be conducted
in accordance with the then-current Model Employment Arbitration Procedures of
the American Arbitration Association ("AAA"), modified to substitute for AAA
actions, the United States Arbitration and Mediation Service ("USA&MS"), before
an arbitrator who is licensed to practice law in the state of Pennsylvania (the
"Arbitrator"). The arbitration shall take place in or near Bethlehem,
Pennsylvania.

                   10.4.1  Selection of Arbitrator. The USA&MS shall give each
party a list of 11 arbitrators drawn from its panel of labor-management dispute
arbitrators. Each party may strike all names on the list it deems unacceptable.
If only one common name remains on the lists of all parties, that individual
shall be designated as the Arbitrator. If more than one common name remains on
the lists of all parties, the parties shall strike names alternately until only
one remains. The party who did not initiate the claim shall strike first. If no
common name remains on the lists of all parties, the USA&MS shall furnish an
additional list or lists until an Arbitrator is selected.

                   10.4.2  Applicable Law. The Arbitrator shall apply the
substantive law (and the law of remedies, if applicable) specified in this
Agreement or federal law, or both, as applicable to the claim(s) asserted. The
Arbitrator, and not any federal, state, or local court or agency, shall have
exclusive authority to resolve any dispute relating to the interpretation,
applicability, enforceability or formation of this Agreement, including but not
limited to any claim that all or any part of this Agreement is void or
voidable. The arbitration shall be final and binding upon the parties, except
as provided in this Agreement.

                   10.4.3  Authority. The Arbitrator shall have jurisdiction to
hear and rule on pre-hearing disputes and is authorized to hold pre-hearing
conferences by telephone or in person as the Arbitrator deems necessary. The
Arbitrator shall have the authority to entertain a motion to dismiss and/or a
motion for summary judgment by any party and shall apply the standards
governing such motions under the Federal Rules of Civil Procedure. The
Arbitrator shall render an award and opinion in the form typically rendered in
labor arbitrations.

                   10.4.4  Representation. Any party may be represented by an
attorney or other representative selected by the party.

                   10.4.5  Discovery. Each party shall have the right to take
the deposition of one individual and any expert witness designated by another
party. Each party also shall have the right to make requests for production of
documents to any party. The subpoena right specified below shall be applicable
to discovery pursuant to this paragraph. Additional discovery may be had only
where the Arbitrator selected pursuant to this Agreement so orders,

                                     -6-
<PAGE>

upon a showing of substantial need. At least 30 days before the arbitration, the
parties must exchange lists of witnesses, including any experts, and copies of
all exhibits intended to be used at the arbitration. Each party shall have the
right to subpoena witnesses and documents for the arbitration.

                   10.4.6  Reporter. Either party, at its expense, may arrange
for and pay the cost of a court reporter to provide a stenographic record of
proceedings.

                   10.4.7  Post-Hearing Briefs. Either party, upon request at
the close of hearing, shall be given leave to file a post-hearing brief. The
time for filing such a brief shall be set by the Arbitrator.

              10.5 Enforcement. Either party may bring an action in any court of
competent jurisdiction to compel arbitration under this Agreement and to
enforce an arbitration award. Except as otherwise provided in this Agreement,
both the Company and Employee agree that neither shall initiate or prosecute
any lawsuit (other than for a non-covered claim) in any way related to any
claim covered by this Agreement. A party opposing enforcement of an award may
not do so in an enforcement proceeding, but must bring a separate action in any
court of competent jurisdiction to set aside the award, where the standard of
review will be the same as that applied by an appellate court reviewing a
decision of a trial court sitting without a jury.

              10.6 Arbitration Fees and Costs. Company and Employee shall
equally share the fees and costs of the Arbitrator. Each party will deposit
funds or post other appropriate security for its share of the Arbitrator's fee,
in an amount and manner determined by the Arbitrator, 10 days before the first
day of hearing. Each party shall pay for its own costs and attorneys' fees, if
any, provided that the Arbitrator, in its sole discretion, may award reasonable
fees to the prevailing party in a proceeding.

         11. General Terms and Conditions. This Agreement constitutes the entire
understanding of the parties relating to the employment of Employee by the
Company, and supersedes and replaces all written and oral agreements heretofore
made or existing by and between the parties relating thereto. This Agreement
shall be construed in accordance with the laws of the state of Pennsylvania,
without regard to any contrary conflicts of laws rules thereof. This Agreement
shall inure to the benefit of any successors or assigns of the Company. All
captions used herein are intended solely for convenience of reference and shall
in no way limit any of the provisions of this Agreement. Employee acknowledges
that he signed this Agreement upon his initial employment with the Company.

         The parties have executed this Employment Agreement as of the date
stated above.

                                             ORASURE TECHNOLOGIES, INC.

/s/ Phillip Michael Formica                  By: /s/ Robert D. Thompson
----------------------------------------        - -----------------------------
Phillip Michael Formica                      Title: Chief Executive Officer
                                                    ---------------------------

                                     -7-
<PAGE>

                       EXHIBIT A TO EMPLOYMENT AGREEMENT

     SPECIFIC DUTIES OF EMPLOYEE AS PRESIDENT AND CHIEF OPERATING OFFICER

         Employee as the President and Chief Operating Officer of the Company
shall be responsible for ______________________________________________________
_______________________________________________________________________________
_______________________________________________________________________________.

                                     -8-<PAGE>

                                                                  Exhibit 10.18
                                                                  -------------

                    AMENDMENT NO. 1 TO PRODUCTION AGREEMENT

          This Amendment No. 1 to Production Agreement (this "Amendment") is
made and entered into this 11th day of December, 2001 by and between OraSure
Technologies, Inc., a Delaware corporation and successor to STC Technologies,
Inc., with its registered offices at Bethlehem, Pennsylvania  18015 U.S.A. (the
"Purchaser"), and Koninklijke Utermohlen N.V., a limited liability company
organized under the laws of the Netherlands, with its registered offices at
Wolvega, the Netherlands (the "Seller").  Seller and Purchaser are each
referred to herein as a "Party" and collectively as the "Parties."

                                   BACKGROUND
                                   ----------

          Seller and Purchaser are parties to a Production Agreement, dated
June 8, 1998 (the "Original Agreement"), pursuant to which Seller agreed to
produce certain products related to the Histofreezer Business for the
Purchaser.  The Parties desire to amend the Original Agreement to, among other
things, provide for the production of new products by Seller for Purchaser and
to extend the term of the Original Agreement, as more fully set forth in this
Amendment.

                                   AGREEMENT
                                   ---------

          NOW, THEREFORE, in consideration of the foregoing, and of the mutual
promises and covenants contained in this Amendment, Seller and Purchaser,
intending to be legally bound, hereby agree as follows:

     1.     Definitions.
            -----------

            1.1  Capitalized terms not otherwise defined in this Amendment shall
                 have the meanings set forth in the Original Agreement.

            1.2  The definition of the term "Specifications" set forth in
                 Article 1 of the Original Agreement is hereby amended and
                 restated as follows:

                   "The term "Specifications" shall mean the technical file set
                   forth in Exhibit 3.1 to this Agreement as the same shall be
                   amended from time to time pursuant to Section 3.1 of this
                   Agreement, together with current ISO 9002/46002 standards,
                   CE standards, all relevant laws, all relevant regulations,
                   all relevant directives, best manufacturing practices and
                   procedures, principles of good workmanship, acknowledged
                   standards and specific (but reasonable) instructions of the
                   Purchaser in the relevant order for any Product(s)."

     2.     Products.  Exhibit 1 to the Original Agreement is hereby amended
            --------
and restated in its entirety as set forth in Exhibit 1 to this Amendment.
<PAGE>

     3.     Specifications and Quality Control.
            ----------------------------------

            3.1  Exhibit 3.1 to the Original Agreement is hereby amended and
                 restated in its entirety as set forth in Exhibit 3.1 to this
                 Amendment.

            3.2  Section 3.4 of the Original Agreement is hereby amended and
                 restated in its entirety as follows:

                   "The Seller shall produce the Products in accordance with
                   the then current ISO 9002/46002 and CE standards.  Copies of
                   all relevant documents related to the production of the
                   Products, including, but not limited to, those documents
                   required to maintain compliance with the Specifications,
                   will be provided by the Seller to the Purchaser upon
                   request.  The parties acknowledge that the Purchaser has
                   obtained CE registration for the Products in its name.  The
                   Seller shall maintain all CE mark files in accordance with
                   good practice for all Products purchased prior to the
                   Purchaser obtaining CE registration in its name.  The
                   Purchaser shall, subject to the Seller's obligation to
                   provide documents under this Article 3.4, be responsible for
                   maintaining the CE mark files for all Products purchased on
                   or after the Purchaser's receipt of the CE registration in
                   its name.  The Purchaser shall supply the Seller with copies
                   of all additions or changes to the CE file relating to the
                   production of the Products.  The Seller shall not modify any
                   method, process or document relating to the production of
                   the Products, including, without limitation, the quality
                   control aspects of production, without first obtaining the
                   Purchaser's prior written consent, which may be granted or
                   withheld in the Purchaser's sole discretion."

     4.     Purchase Price.
            --------------

            4.1  Exhibit 4.1 to the Original Agreement is hereby amended and
                 restated in its entirety as set forth in Exhibit 4.1 to this
                 Amendment.  The prices set forth in Exhibit 4.1 to this
                 Amendment shall apply to all Products purchased on or after the
                 date of this Amendment.

            4.2  The reference to "30%" set forth in Article 4.2 of the Original
                 Agreement is hereby changed to "10%."

            4.3  All payments required by either Party under the Original
                 Agreement, as amended by this Amendment, shall be made in
                 Euros.

     5.     Delivery.  The references to "Incoterms 1990 of the International
            --------
Chamber of Commerce" in Sections 5.2 and 5.3 of the Original Agreement are
hereby changed to "Incoterms 2000 of the International Chamber of Commerce."

                                     -2-
<PAGE>

     6.     Penalty Clause.
            --------------

            6.1  Article 10.1(i) of the Original Agreement is hereby amended and
                 restated in its entirety as follows:

                   "Articles 7, 9 and 16.7 of this Agreement and Article 11 of
                   the Asset Purchase Agreement shall be considered by the
                   Parties hereto as an event of gross default ("Gross
                   Default"); and"

            6.2  The references to "NGL 250,000", "NGL 10,000" and "NGL 500,000"
                 set forth in Article 10.2 are hereby changed to "EUR 113,446,"
                 "EUR 4,538," and "EUR 226,891," respectively.

     7.     Replacement and Recall of Products.  The reference to "5 Working
            ----------------------------------
Days" in Article 11.1 of the Original Agreement is hereby changed to "10
Working Days."

     8.     Duration and Termination.
            ------------------------

            8.1  The first sentence of Article 13.1 of the Original Agreement is
                 hereby amended and restated as follows:

                   "This Agreement shall be in force commencing on June 1, 1998
                   and terminating on the later of (i) December 31, 2006 and
                   (ii) the date on which the Purchaser shall have ordered and
                   the Seller shall have supplied Products having an aggregate
                   of 30,000,000 treatment applications."

            The date specified in clause (ii), above, shall be determined only
            by reference to the Products ordered and purchased on or after
            December 11, 2001.  The number of treatment applications shall be
            determined by reference to the number of treatment applicators sold
            with aerosol canisters to the Purchaser.

            8.2  Article 13.3(a) is hereby amended and restated in its entirety
                 as follows:

                   "if there are changes in the direct or indirect control or
                   ownership (the shares in the capital or otherwise) of the
                   Seller and the Purchaser does not provide its written consent
                   for the same prior to such change, which consent may be
                   granted or withheld in the Purchaser's sole discretion; or"

                                     -3-
<PAGE>

     9.     Notices.  The notice information for the Purchaser set forth in
            -------
Article 14.1 of the Original Agreement is hereby amended and restated as
follows:

                   "If to the Purchaser:

                   OraSure Technologies, Inc.
                   150 Webster Street
                   Bethlehem, Pennsylvania 18015
                   U.S.A.

                   To the attention of: President"

     10.    Assignment.  Article 16.7 of the Original Agreement is hereby
            ----------
amended and restated in its entirety as follows:

                   "None of the rights or obligations under this Agreement may
                   be assigned or transferred by the Seller without the prior
                   written consent of the Purchaser, which consent may be
                   granted or withheld in the Purchaser's sole discretion.  The
                   Seller and the Purchaser can, without obtaining the prior
                   consent of the other, fully assign and transfer any
                   ("cessie") or all ("contractsoverneming") of its respective
                   rights and obligations under this Agreement to an affiliated
                   company.  An affiliated company of a party shall mean a
                   company or entity which controls, is controlled by or is
                   under common control with such party.  Notwithstanding the
                   foregoing, a change in ownership or control of the Seller
                   shall be deemed to be a transfer of the Agreement by the
                   Seller requiring the Purchaser's prior written consent,
                   which consent may be granted or withheld in the Purchaser's
                   sole discretion.  The Purchaser may, without the consent of
                   the Seller, freely assign any ("cessie") or all
                   ("contractsoverneming") of its rights and obligations under
                   this Agreement to any third party.  To the extent either the
                   Seller or the Purchaser assigns or transfers its rights and
                   obligations under this Agreement to any party in accordance
                   with this Article 16.7, the assignee of the Seller shall be
                   deemed to be the "Seller", and the assignee of the Purchaser
                   shall be deemed to be the "Purchaser", for purposes of this
                   Agreement."

     11.    Party References.  All references to the Purchaser in the Original
            ----------------
Agreement are hereby deemed to mean OraSure Technologies, Inc., as successor by
merger to STC Technologies, Inc.

     12.    No Other Changes.  Except as set forth in this Amendment, the
            ----------------
Original Agreement remains in full force and effect without any other changes.
The Original Agreement, together with this Amendment, constitute the entire
agreement between the Seller and the Purchaser with respect to the subject
matter hereof and thereof and supersede and cancel all previous negotiations,
agreements, and commitments, whether

                                     -4-
<PAGE>

oral or in writing, with respect to such subject matter.  All references to the
Agreement shall be deemed to mean the Agreement as amended by this Amendment.

     13.    Counterparts.  This Amendment may be executed in two or more
            ------------
counterparts, each of which shall be deemed to be an original, but all of which
together shall constitute one and the same instrument.  A facsimile
transmission of a signed original shall be deemed to be the same as delivery of
a signed original.

     14.    Governing Law.  This Amendment and any controversy, claim or
            -------------
dispute arising under this Amendment shall be governed by, and construed in
accordance with, the laws of the Netherlands.

            IN WITNESS WHEREOF, the undersigned duly authorized officers of the
Seller and the Purchaser have executed this Amendment as of the date first above
written.

ORASURE TECHNOLOGIES, INC.                  KONINKLIJKE UTERMOHLEN N.V.

By: /s/ Michael J. Gausling                 By: /s/ Don T. van der Vat
    -------------------------------             -------------------------------
    Name: Michael J. Gausling                   Name: Don T. van der Vat
    Title:  President and                       Title:  Managing Director
            Chief Executive Officer

                                     -5-
<PAGE>

                                  EXHIBIT 1

                                 THE PRODUCTS
                                 ------------

Art.nr.        Description
----           -----------
123070         Histofreezer Dutch/French 5mm (40 applicators)
123082         Histofreezer English 5mm (40 applicators)
123086         Histofreezer English 2mm (50 applicators)
123080         Histofreezer DPC Norway 5mm (40 applicators)
123079         Histofreezer Uhlmann 5mm (40 applicators)
122010         Histofreezer Uhlmann 2mm (50 applicators)
F78040         Histofreezer Askina French 5mm (40 applicators)
F78050         Histofreezer Askina French 2mm (50 applicators)
321059         Histofreezer Askina Spanish 5mm (40 applicators)
325897         Histofreezer Askina Spanish 2mm (50 applicators)
09381007       Histofreezer Askina German 5mm (40 applicators)
09381015       Histofreezer Askina German 2mm (50 applicators)
002556         Histofreezer Paladin Mix (50 applicators)
H-60           Histofreezer OraSure USA Mix (60 applicators)
H-135          Histofreezer United Medical Mix (50 applicators)
H-140          Histofreezer Mexico Mix (50 applicators)
H-150          Histofreezer English Mix (50 applicators)
H-155          Histofreezer Uhlmann Mix (50 applicators)
H-505          Histofreezer OraSure USA 5mm (50 applicators)
H-105          Histofreezer Sample Mix (5 applicators)
H-110          Histofreezer (Glaxo) Mix (10 applicators)
H-109          Supplementary Applicators 20 x 2mm
H-119          Supplementary Applicators 20 x 5mm

                                     -6-
<PAGE>

                                  EXHIBIT 3.1

                                 SPECIFICATIONS
                                 --------------

                                     -7-
<PAGE>

                                  EXHIBIT 4.1

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00036-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00036-of-00352.parquet"}]]