Document:

Amendment No. 1 to Agreement of Purchase and Sale

 Exhibit 10.2 
 AMENDMENT NO. 1 TO AGREEMENT OF PURCHASE AND SALE 
 This Amendment No. 1 is made and entered into effective
as of August 1, 2006 (this “Amendment”) and amends the Agreement of Purchase and Sale, dated as of June 4, 2006 (the “Agreement”), by and among International Paper Company, a corporation organized under the laws of the State of
New York (“Seller”), CMP Investments LP, a limited partnership organized under the laws of the State of Delaware (“Parent”), and CMP Holdings LLC, a limited liability company organized under the laws of the State of Delaware and
an indirect, wholly-owned subsidiary of Parent (“Buyer” and, together with Parent, the “Acquirors”). Capitalized terms used but not defined herein shall have the meanings set forth in the Agreement. 
 WHEREAS, Seller and the Acquirors wish to amend the Agreement as set forth herein; 
 WHEREAS, Seller and the Acquirors wish to amend the Seller Disclosure Letter as described herein; 
 WHEREAS, Seller and the Acquirors wish to amend certain Schedules to the Agreement as described herein. 
 NOW, THEREFORE, for good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, and intending to be legally bound
hereby, each of Seller and the Acquirors agree as follows: 
  

	1.	Section 1.1 of the Agreement is hereby amended to delete the definition of “Ancillary Agreements” in its entirety and insert in lieu thereof the following:

 “Ancillary Agreements” shall mean (i) the Transition Services Agreement, (ii) the Tax Exempt Bond Agreement, (iii)
the Litigation Support Agreement, (iv) the Quinnesec Wood Supply Agreement, (v) the Sartell Sublease, (vi) the Intellectual Property Agreement, (vii) the Intellectual Property Assignments, (viii) the Joint Purchasing Agreement, (ix) the Hinton Pulp
Supply Agreement, (x) the Amended and Restated Limited Partnership Agreement, (xi) the Roll-Wrap Agreement and (xii) Spare Parts Agreement.” 
  

	2.	Section 1.1 of the Agreement is hereby amended to delete the definition of “Benchmark” in its entirety and insert in lieu thereof the following: 

“Benchmark” shall mean $153,075,000 (one hundred fifty three million and seventy-five thousand dollars).” 
  

	3.	Section 1.1 of the Agreement is hereby amended to delete subsection (iii) of the definition of “Permitted Encumbrances” in its entirety and insert in lieu thereof the
following: 

 “(iii) except as set forth on Amended Schedule VIII, matters shown on the title insurance or commitments
listed in Section 4.15 of the Seller Disclosure Letter,” 
  

	4.	Section 1.1 of the Agreement is hereby amended to insert the following: 

 “Roll-Wrap Agreement” shall mean the roll-wrap agreement, to be executed and delivered on the Closing Date, between Buyer and Seller, in the form attached hereto as Annex K.” 

	5.	Section 1.1 of the Agreement is hereby amended to insert the following: 

 “Spare Parts Agreement” shall mean the spare parts agreement, to be executed and delivered on the Closing Date, between Buyer and Seller, pursuant to which Buyer and Seller will be able to purchase spare
parts from each other, in the form attached hereto as Annex L.” 
  

	6.	Section 2.3(b) of the Agreement is hereby amended to delete subsection (v) thereof in insert in lieu thereof the following: 

 “(v) all liabilities and obligations arising out of, resulting from or relating to the matters described in Amended Schedule VI (the “Excluded
Litigation Matters”)” 
  

	7.	Section 2.10 of the Agreement is hereby amended to insert a new subsection (c) as follows: 

  

	 	(c)	“Notwithstanding anything to the contrary set forth in Section 2.1, if, on the Closing Date, ARCo or a stockholder of ARCo other than Seller shall not have purchased the ARCo
Shares at the offer price of $2,000,000 set forth in the offer notice delivered by Seller to ARCo and its shareholders pursuant to the ARCo ROFR, Seller shall sell, convey, assign, transfer and deliver to Buyer and Buyer shall purchase, acquire and
accept from Seller, the ARCo Shares subject to the ARCo ROFR. For the avoidance of doubt, if ARCo or a stockholder of ARCo other than Seller elects to exercise its ARCo ROFR following the Closing, then (i) Buyer shall deliver the ARCo Shares to such
exercising party and (ii) the proceeds paid in connection with the exercise of such right and purchase of the ARCo Shares shall belong to Buyer.” 

  

	8.	Section 4.4 of the Agreement is hereby amended to delete the reference to “Section 4.4(a) of the Seller Disclosure Letter” and insert in lieu thereof “Amended Section
4.4 of the Seller Disclosure Letter”. 

  

	9.	Section 6.33 of the Agreement is hereby amended to insert the following as the last sentence thereof: 

 “Seller shall indemnify Buyer, and Buyer shall not be responsible, for any damages arising from Seller’s failure to obtain the consent of any
landlord necessary to sublease office space as provided for in this Section 6.33 and the Transition Services Agreement, except for such liabilities that arise from Buyer’s failure to take such actions as are reasonably necessary to obtain such
consents.” 
  

	10.	Section 6.35 of the Agreement is hereby amended to delete the text thereof in its entirety and in insert in lieu thereof the following: 

 “Prior to or at Closing, Buyer will execute the following agreements to the extent necessary for the Seller’s provision of transition services
to Buyer under the Transition Services Agreement: (1) necessary license agreements with CINCOM and H&W Software; (2) services agreements with EDS and ADP; and (3) a transitional services agreement with SAP. As soon as practicable following
Closing, Buyer will execute a license agreement with GT Software.” 
  

	11.	Section 7.2 of the Agreement is hereby amended to delete subsection (g) thereof in insert in lieu thereof the following: 

  

	 	(g)	“Seller shall have obtained the written consents, in form and substance reasonably satisfactory to Buyer, set forth in Amended Section 7.2(g) of the Seller Disclosure
Letter.” 

	12.	Section 10.9 of the Agreement is hereby amended to delete the parenthetical phrase in clause (i) thereof in its entirety and insert in lieu thereof the following:

 “(other than (A) the Intellectual Property Agreement, which may be assigned in accordance with its terms, and (B), in
the case of Buyer, the Transition Services Agreement)” 
  

	13.	The Seller Disclosure Letter is hereby amended to delete Section 4.4(a) and insert in lieu thereof Exhibit A hereto (“Amended Section 4.4(a) of the Seller Disclosure
Letter”). 

  

	14.	Section 4.12(a)(ii) on the Seller Disclosure Letter is hereby amended to add the following trademark: 

 “Quinnesec, US Registration No. 1232416, registered on March 29, 1983”. 
  

	15.	The Seller Disclosure Letter is hereby amended to delete Section 7.2(g) and insert in lieu thereof Exhibit B hereto (“Amended Section 7.2(g) of the Seller Disclosure
Letter”). 

  

	16.	Section 6.8(a)(i) of the Seller Disclosure Letter is hereby amended as set forth in Exhibit C. 

  

	17.	Schedule VI (Certain Excluded Liabilities) to the Agreement is hereby deleted in its entirety and replaced with Schedule VI set forth in Exhibit D hereto (“Amended Schedule
VI”). 

  

	18.	The heading of Schedule VI (Purchase Price Allocation) is hereby deleted in its entirety and replaced with “Schedule VII”. 

  

	19.	Schedule VII (Permitted Encumbrance Exceptions) to the Agreement is hereby deleted in its entirety and replaced with Schedule VIII set forth in Exhibit E hereto (“Amended
Schedule VIII”). 

  

	20.	The Table of Contents of the Agreement is amended to delete the references to Schedule IX (Seller Transition and Migration Tasks) and Schedule X (Buyer Transition and Migration
Tasks). 

  

	21.	THIS AGREEMENT, INCLUDING ALL MATTERS OF CONSTRUCTION, VALIDITY AND PERFORMANCE, SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK, WITHOUT
REGARD TO PRINCIPLES OF CONFLICTS OR CHOICE OF LAWS OR ANY OTHER LAW THAT WOULD MAKE THE LAWS OF ANY OTHER JURISDICTION OTHER THAN THE STATE OF NEW YORK APPLICABLE HERETO. 

  

	22.	Except to the extent amended hereby, the provisions of the Agreement shall remain unmodified, and the Agreement, as amended by this Amendment shall remain in full force and effect
in accordance with its terms. 

  

	23.	This Amendment may be executed simultaneously in counterparts, each of which shall be deemed an original but all of which together shall constitute one and the same instrument.

 IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be executed as of the date first
written above by their respective officers thereunto duly authorized. 
  

			
	 INTERNATIONAL PAPER COMPANY

		
	By:	 	 /s/ C. Cato Ealy

		 	 Name: C. Cato Ealy

		 	 Title:   Senior Vice President

	
	CMP HOLDINGS LLC
		
	By:	 	 /s/ Scott Kleinman

		 	 Name: Scott Kleinman

		 	Title:   President
	
	CMP INVESTMENTS LP
		
	By:	 	CMP INVESTMENTS MANAGEMENT LLC
		 	Its General Partner
		
	By:	 	 /s/ Scott Kleinman

		 	 Name: Scott Kleinman

		 	Title:   PresidentAmended and Restated Certificate of Incorporation of CV Therapeutics, Inc.

 EXHIBIT 4.1 
 CV Therapeutics, Inc. 
 AMENDED AND RESTATED 
 CERTIFICATE OF INCORPORATION 
 (filed
pursuant to sec. 242 & 245) 
 OF 
 CV THERAPEUTICS, INC. 
 Louis G. Lange, M.D., Ph.D. does hereby certify: 
 1. He is the Chairman of the Board and Chief Executive Officer of CV Therapeutics, Inc., a corporation organized and existing under the laws of the state
of Delaware. The original Certificate of Incorporation was filed with the Secretary of State of the State of Delaware on December 11, 1990. 
 2. The Amended and Restated Certificate of Incorporation, as amended, of this Corporation is hereby amended and restated as follows: 
 I. 
 The name of this Corporation is CV Therapeutics, Inc. 
 II. 
 The address of the registered office of the Corporation in the State of
Delaware is 1013 Centre Road, City of Wilmington, County of New Castle, and the name of the registered agent of the Corporation in the State of Delaware at such address is The Prentice-Hall Corporation System, Inc. 
 III. 
 The purpose of the Corporation
is to engage in any lawful act or activity for which a corporation may be organized under the General Corporation Law of the State of Delaware. 
 IV. 
 A. The Corporation is authorized to issue two classes of stock to be designated, respectively, “Common
Stock” and “Preferred Stock.” The total number of shares which the Corporation is authorized to issue is one hundred eighty five million (185,000,000) shares. One hundred eighty million (180,000,000) shares shall be Common Stock each
having a par value of one tenth of one cent ($.001). Five million (5,000,000) shares shall be Preferred Stock, each having a par value of one tenth of one cent ($.001). 
 B. The Preferred Stock may be issued from time to time in one or more series. The Board of Directors is hereby authorized, by filing a certificate (a “Preferred Stock Designation”) pursuant to the
Delaware General Corporation Law, to fix or alter from time to time the designation, powers, preferences and rights of the shares of each such series and the qualifications, limitations or restrictions of any wholly unissued series of Preferred
Stock, and to establish from time to time the number of shares constituting any such series or any of them; and to increase or decrease the number of shares of any series subsequent to the issuance of shares of that series, but not below the number
of shares of such series then outstanding. In case the number of shares of any series shall be decreased in accordance with the foregoing sentence, the shares constituting such decrease shall resume the status that they had prior to the adoption of
the resolution originally fixing the number of shares of such series. 

 C. The rights, preferences, privileges and restrictions granted to and imposed on the first series
of such Preferred Stock, the Series A Junior Participating Preferred Stock, are as set forth below in this Fourth Article. 
 Section 1. Designation and Amount. Eight hundred fifty thousand (850,000) shares of Preferred Stock, $.001 par value, are designated “Series A Junior Participating Preferred Stock” with the designations
and the powers, preferences and rights, and the qualifications, limitations and restrictions specified herein (the “Junior Preferred Stock”). Such number of shares may be increased or decreased by resolution of the Board of Directors;
provided , that no decrease shall reduce the number of shares of Junior Preferred Stock to a number less than the number of shares then outstanding plus the number of shares reserved for issuance upon the exercise of outstanding options, rights
or warrants or upon the conversion of any outstanding securities issued by the Corporation convertible into Junior Preferred Stock. 
 Section 2. Dividends and Distributions. 
 (A) Subject to the rights of the holders of any shares of any series
of Preferred Stock (or any similar stock) ranking prior and superior to the Junior Preferred Stock with respect to dividends, the holders of shares of Junior Preferred Stock, in preference to the holders of Common Stock and of any other junior
stock, shall be entitled to receive, when, as and if declared by the Board of Directors out of funds legally available for the purpose, quarterly dividends payable in cash on the first day of April, July, October and January in each year (each such
date being referred to herein as a “Quarterly Dividend Payment Date”), commencing on the first Quarterly Dividend Payment Date after the first issuance of a share of fraction of a share of Junior Preferred Stock, in an amount per share
(rounded to the nearest cent) equal to the greater of (a) $1.00 or (b) subject to the provision for adjustment hereinafter set forth, 100 times the aggregate per share amount of all cash dividends, and 100 times the aggregate per share
amount (payable in kind) of all non-cash dividends or other distributions, other than a dividend payable in shares of Common Stock or a subdivision of the outstanding shares of Common Stock (by reclassification or otherwise), declared on the Common
Stock since the immediately preceding Quarterly Dividend Payment Date or, with respect to the first Quarterly Dividend Payment Date, since the first issuance of any share or fraction of a share of Junior Preferred Stock. In the event the Corporation
shall at any time declare or pay any dividend on the Common Stock payable in shares of Common Stock, or effect a subdivision or combination or consolidation of the outstanding shares of Common Stock (by reclassification or otherwise than by payment
of a dividend in shares of Common Stock) into a greater or lesser number of shares of Common Stock, then in each such case the amount to which holders of shares of Junior Preferred Stock were entitled immediately prior to such event under clause
(b) of the preceding sentence shall be adjusted by multiplying such amount by a fraction, the numerator of which is the number of shares of Common Stock outstanding immediately after such event and the denominator of which is the number of
shares of Common Stock that were outstanding immediately prior to such event. 
 (B) The Corporation shall declare a dividend or
distribution on the Junior Preferred Stock as provided in paragraph (A) of this Section immediately after it declares a dividend or distribution on the Common Stock (other than a dividend payable in shares of Common Stock); provided ,
that in the event no dividend or distribution shall have been declared on the Common Stock during the period between any Quarterly Dividend Payment Date and the next subsequent Quarterly Dividend Payment Date, a dividend of $1.00 per share on the
Junior Preferred Stock shall nevertheless be payable on such subsequent Quarterly Dividend Payment Date. 
 (C) Dividends shall begin to
accrue and be cumulative on outstanding shares of Junior Preferred Stock from the Quarterly Dividend Payment Date next preceding the date of issue of such shares, unless 

 
the date of issue of such shares is prior to the record date for the first Quarterly Dividend Payment Date, in which case dividends on such shares shall
begin to accrue from the date of issue of such shares, or unless the date of issue is a Quarterly Dividend Payment Date or is a date after the record date for the determination of holders of shares of Junior Preferred Stock entitled to receive a
quarterly dividend and before such Quarterly Dividend Payment Date, in either of which events such dividends shall begin to accrue and be cumulative from such Quarterly Dividend Payment Date. Accrued but unpaid dividends shall 
 not bear interest. Dividends paid on the shares of Junior Preferred Stock in an amount less than the total amount of such dividends at the time accrued and payable on
such shares shall be allocated pro rata on a share-by-share basis among all such shares at the time outstanding. The Board of Directors may fix a record date for the determination of holders of shares of Junior Preferred Stock entitled to receive
payment of a dividend or distribution declared thereon, which record date shall be not more than 60 days prior to the date fixed for the payment thereof. 
 Section 3. Voting Rights. The holders of the Junior Preferred Stock shall have the following voting rights: 
 (A) Subject to the provision for adjustment hereinafter set forth, each share of Junior Preferred Stock shall entitle the holder thereof to 100 votes on all matters submitted to a vote of the stockholders of the
Corporation. In the event the Corporation shall at any time declare or pay any dividend on the Common Stock payable in shares of Common Stock, or effect a subdivision or combination or consolidation of the outstanding shares of Common Stock (by
reclassification or otherwise than by payment of a dividend in shares of Common Stock) into a greater or lesser number of shares of Common Stock, then in each such case the number of votes per share to which the holders of shares of Junior Preferred
Stock were entitled immediately prior to such event shall be adjusted by multiplying such number by a fraction, the numerator of which is the number of shares of Common Stock outstanding immediately after such event and the denominator of which is
the number of shares of Common Stock that were outstanding immediately prior to such event. 
 (B) Except as otherwise provided herein,
in any Preferred Stock Designation or by law, the holders of shares of Junior Preferred Stock and the holders of shares of Common Stock and any other capital stock of the Corporation having general voting rights shall vote together as one class on
all matters submitted to a vote of stockholders of the Corporation. 
 (C) Except as set forth herein, or as otherwise provided by law,
holders of Junior Preferred Stock shall have not special voting rights and their consent shall not be required (except to the extent they are entitled to vote with holders of Common Stock as set forth herein) for taking any corporate action.

 Section 4. Certain Restrictions. 
 (A) Whenever quarterly dividends or other dividends or distributions payable on the Junior Preferred Stock as provided in Section 2 are in arrears, thereafter and until all accrued and unpaid dividends and
distributions, whether or not declared, on shares of Junior Preferred Stock outstanding shall have been paid in full, the Corporation shall not: 
 (i) declare or pay dividends, or make any other distributions, on any shares of stock ranking junior (either as to dividends or upon liquidation, dissolution or winding up) to the Junior Preferred Stock; 
 (ii) declare or pay dividends, or make any other distributions, on any shares of stock ranking on a parity (either as to dividends or upon liquidation,
dissolution or winding up) with the Junior Preferred Stock, except dividends paid ratably on the Junior Preferred Stock and all such parity stock on which dividends are payable or in arrears in proportion to the total amounts to which the holders of
all such shares are then entitled; 

 (iii) redeem or purchase or otherwise acquire for consideration shares of any stock ranking junior
(either as to dividends or upon liquidation, dissolution or winding up) to the Junior Preferred Stock, provided that the Corporation may at any time redeem, purchase or otherwise acquire shares of any such junior stock in exchange for shares of any
stock of the Corporation ranking junior (either as to dividends or upon dissolution, liquidation or winding up) to the Junior Preferred Stock; or 
 (iv) redeem or purchase or otherwise acquire for consideration any shares of Junior Preferred Stock, or any shares of stock ranking on a parity (either as to dividends or upon liquidation, dissolution or winding up) with the Junior
Preferred Stock, except in accordance with a purchase offer made in writing or by publication (as determined by the Board of Directors) to all holders of such shares upon such terms as the Board of Directors, after consideration of the respective
annual dividend rates and other relative rights and preferences of the respective series and classes, shall determine in good faith will result in fair and equitable treatment among the respective series or classes. 
 (B) The Corporation shall not permit any subsidiary of the Corporation to purchase or otherwise acquire for consideration any shares of stock of the
Corporation unless the Corporation could, under paragraph (A) of this Section 4, purchase or otherwise acquire such shares at such time and in such manner. 
 Section 5. Reacquired Shares. Any shares of Junior Preferred Stock purchased or otherwise acquired by the Corporation in any manner whatsoever shall be retired and cancelled promptly after the
acquisition thereof. All such shares shall upon their cancellation become authorized but unissued shares of Preferred Stock and may be reissued as part of a new series of Preferred stock subject to the conditions and restrictions on issuance set
forth herein, or in any Preferred Stock Designation or as otherwise required by law. 
 Section 6. Liquidation, Dissolution or
Winding Up. Upon any liquidation, dissolution or winding up of the Corporation, no distribution shall be made (1) to the holders of shares of stock ranking junior (either as to dividends or upon liquidation, dissolution or winding up) to
the Junior Preferred Stock unless, prior thereto, the holders of shares of Junior Preferred Stock shall have received $100 per share, plus an amount equal to accrued and unpaid dividends and distributions thereon, whether or not declared, to the
date of such payment, provided that the holders of shares of Junior Preferred Stock shall be entitled to receive an aggregate amount per share, subject to the provisions for adjustment hereinafter set forth, equal to 100 times the aggregate amount
to be distributed per share to holders of shares of Common Stock, or (2) to the holders of shares of stock ranking on a parity (either as to dividends or upon liquidation, dissolution or winding up) with the Junior Preferred Stock, except
distributions made ratably on the Junior Preferred Stock and all such parity stock in proportion to the total amounts to which the holders of all such shares are entitled upon such liquidation, dissolution or winding up. In the event the Corporation
shall at any time declare or pay any dividend on the Common Stock payable in shares of Common Stock or effect a subdivision or combination or consolidation of the outstanding shares of Common Stock (by reclassification or otherwise than by payment
of a dividend in shares of Common Stock) into a greater or lesser number of shares of Common Stock, then in each such case the aggregate amount to which holders of shares of Junior Preferred Stock were entitled immediately prior to such event under
the proviso in clause (1) of the preceding sentence shall be adjusted by multiplying such amount by a fraction the numerator of which is the number of shares of Common Stock outstanding immediately after such event and the denominator of which
is the number of shares of Common Stock that were outstanding immediately prior to such event. 
 Section 7. Consolidation,
Merger, etc. In case the Corporation shall enter into any consolidation, merger, combination or other transactions in which the shares of Common Stock are exchanged for or 

 
changed into other stock or securities, cash and/or any other property, then in any such case each share of Junior Preferred Stock shall at the same time be
similarly exchanged or changes into an amount per share, subject to the provision for adjustment hereinafter set forth, equal to 100 times the aggregate amount of stock, securities, cash and/or any other property (payable in kind), as the case may
be, into which or for which each share of Common Stock is changes or exchanged. In the event the Corporation shall at any time declare or pay any dividend on the Common Stock payable in shares of Common Stock, or effect a subdivision or combination
or consolidation of the outstanding shares of Common Stock (by reclassification or otherwise than by payment of a dividend in shares of Common Stock) into a greater or lesser number of shares of Common Stock, then in each such case the amount set
forth in the preceding sentence with respect to the exchange or change of shares of Junior Preferred Stock shall be adjusted by multiplying such amount by a fraction, the numerator of which is the number of shares of Common Stock outstanding
immediately after such event and the denominator of which is the number of shares of Common Stock that were outstanding immediately prior to such event. 
 Section 8. No Redemption. The shares of Junior Preferred Stock shall not be redeemable. 
 Section 9. Rank. The Junior Preferred Stock shall rank, with respect to the payment of dividends and the distribution of assets, junior to all series of any other class of Preferred Stock. 
 Section 10. Amendment. This Amended and Restated Certificate of Incorporation shall not be amended in any manner which would materially
alter or change the powers, preferences or special rights of the Junior Preferred Stock so as to affect them adversely without the affirmative vote of the holders of at least two-thirds of the outstanding shares of Junior Preferred Stock, voting
together as a single class. 
 V. 
 For the management of the business and for the conduct of the affairs of the Corporation, and in further definition, limitation and regulation of the powers of the Corporation, of its directors and of its stockholders or any class thereof,
as the case may be, it is further provided that: 
 A. 
 (1) The management of the business and the conduct of the affairs of the Corporation shall be vested in its Board of Directors. The
number of directors which shall constitute the whole Board of Directors shall be fixed exclusively by one or more resolutions adopted from time to time by the Board of Directors. 
 (2) Subject to the rights of the holders of any series of Preferred Stock to elect additional directors under specified circumstances,
following the date on which the Corporation is no longer subject to Section 2115 of the California Corporations Code (the “Qualifying Record Date”), the directors shall be divided into three classes designated as Class I,
Class II and Class III, respectively. Directors shall be assigned to each class in accordance with a resolution or resolutions adopted by the Board of Directors. At the first annual meeting of stockholders following the Qualifying Record
Date, the term of office of the Class I directors shall expire and Class I directors shall be elected for a full term of three years. At the second annual meeting of stockholders, following the Qualifying Record Date, the term of office of
the Class II directors shall expire and Class II directors shall be elected for a full term of three years. At the third annual meeting of stockholders following the Qualifying Record Date, the term of office of the Class III
directors shall expire and Class III directors shall be elected for a full term of three years. At each succeeding annual meeting of stockholders, directors shall be elected for a full term of three years to succeed the directors of the class
whose terms expire at such annual meeting. 

 Notwithstanding the foregoing provisions of this Article, each director shall serve until his or her
successor is duly elected and qualified or until his or her death, resignation or removal. No decrease in the number of directors constituting the Board of Directors shall shorten the term of any incumbent director. 
 (3) Subject to the rights of the holders of any series of Preferred Stock, the Board of Directors or any individual director may be
removed from office at any time (i) with cause by the affirmative vote of the holders of a majority of the voting power of all the then outstanding shares of voting stock of the Corporation, entitled to vote at an election of directors (the
“Voting Stock”) or (ii) without cause by the affirmative vote of the holders of at least sixty-six and two-thirds percent (66 2/3%) of the voting power of all the then-outstanding shares of the Voting Stock. 
 (4) Subject to the rights of the holders of any series of Preferred Stock, any vacancies on the Board of Directors resulting from death,
resignation, disqualification, removal or other causes and any newly created directorships resulting from any increase in the number of directors, shall, unless the Board of Directors determines by resolution that any such vacancies or newly created
directorships shall be filled by the stockholders, except as otherwise provided by law, be filled only by the affirmative vote of a majority of the directors then in office, even though less than a quorum of the Board of Directors, and not by the
stockholders. Any director elected in accordance with the preceding sentence shall hold office for the remainder of the full term of the director for which the vacancy was created or occurred and until such director’s successor shall have been
elected and qualified. 
 B. 
 (1) Subject to paragraph (h) of Section 43 of the Bylaws, the Bylaws may be altered or amended or new Bylaws adopted by the affirmative vote of at least sixty-six and two-thirds percent (66  2/3%) of the voting power of all of the then-outstanding shares of the Voting Stock. The Board of Directors shall also
have the power to adopt, amend, or repeal Bylaws. 
 (2) The directors of the Corporation need not be elected by
written ballot unless the Bylaws so provide. 
 (3) No action shall be taken by the stockholders of the Corporation except at
an annual or special meeting of stockholders called in accordance with the Bylaws and no action shall be taken by the stockholders by written consent. 
 (4) Special meetings of the stockholders of the Corporation may be called, for any purpose or purposes, by (i) the Chairman of the Board of Directors, (ii) the Chief Executive Officer, (iii) the Board
of Directors pursuant to a resolution adopted by a majority of the total number of authorized directors (whether or not there exist any vacancies in previously authorized directorships at the time any such resolution is presented to the Board of
Directors for adoption) or (iv) by the holders of the shares entitled to cast not less than percent (10%) of the votes at the meeting, and shall be held at such place, on such date, and at such time as the Board of Directors shall fix.

 (5) Advance notice of stockholder nominations for the election of directors and of business to be brought by stockholders
before any meeting of the stockholders of the Corporation shall be given in the manner provided in the Bylaws of the Corporation. 
 VI.

 A. To the maximum extent permitted by the Delaware General Corporation Law, as the same exists or as may hereafter be amended, a
director of the Corporation shall not be personally liable to the Corporation or its stockholders for monetary damages for breach of fiduciary duty as a director. 

 B. The Corporation shall indemnify to the fullest extent permitted by law any person made or
threatened to be made a party to an action or proceeding, whether criminal or civil, administrative or investigative, by reason of the fact that he or she, or his or her testator or intestate is or was a director or officer of the Corporation or any
predecessor of the Corporation, or serves or served at any other enterprise as a director or officer at the request of the Corporation or any predecessor to the Corporation. 
 C. Neither any amendment nor repeal of this Article VI, nor the adoption of any provision of the Corporation’s certificate of
incorporation inconsistent with this Article VI, shall eliminate or reduce the effect of this Article VI in respect of any matter occurring, or any action or proceeding accruing or arising or that, but for this Article VI, would accrue or
arise, prior to such amendment, repeal or adoption of an inconsistent position. 
 VII. 
 A. The Corporation reserves the right to amend, alter, change or repeal any provision contained in this Amended and Restated Certificate of
Incorporation, in the manner now or hereafter prescribed by statute, except as provided in Section 10 of paragraph C of Article IV and paragraph B of this Article VII, and all rights conferred upon the stockholders herein are granted
subject to this reservation. 
 B. Notwithstanding any other provisions of this Amended and Restated Certificate of Incorporation or any
provision of law which might otherwise permit a lesser vote or no vote, but in addition to any affirmative vote of the holders of any particular class or series of the Voting Stock required by law, this Amended and Restated Certificate of
Incorporation or any Preferred Stock Designation, the affirmative vote of the holders of at least sixty-six and two-thirds percent (66 2/3%) of the voting power of all of the then-outstanding shares of the Voting Stock, voting together as a
single class, shall be required to alter, amend or repeal Articles V, VI, and VII. 
 The foregoing Amended and Restated Certificate of
Incorporation has been duly approved by the Board of Directors. 
 The foregoing Amended and Restated Certificate of Incorporation has been
duly approved by the vote of the stockholders in accordance with Sections 242 and 245 of the Delaware General Corporation Law. The total number of outstanding shares of the Corporation entitled to vote on the amendment was 45,052,027 shares of
Common Stock as of April 12, 2006. The number of shares voting in favor of the amendment equaled or exceeded the vote required. The percentage vote required was more than 50% of the Common Stock. 
 I further declare under penalty of perjury under the laws of the state of Delaware that the matters set forth in this Amended and Restated Certificate of
Incorporation are true and correct. 
  

	
	 /s/ Louis G. Lange

	Louis G. Lange, M.D., Ph.D.
	Chairman of the Board and
	Chief Executive Officer

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