Document:

EX-4.1

 Exhibit 4.1 
  

 
 Twenty-Second Supplemental
Indenture 
 Dated as of May 12, 2014 

Supplement to the Amended and Restated Indenture 

Dated as of April 22, 2005 
  

 
 PACIFIC GAS
AND ELECTRIC COMPANY 
 Issuer 

and 
 THE BANK OF NEW
YORK MELLON TRUST COMPANY, N.A. 
 Trustee 
  

 
  

 
  

 TABLE OF CONTENTS 

 

							
	 	  	 	  	Page	 
	ARTICLE I	  	 DEFINITIONS
	  	 	2	  
	ARTICLE II	  	 ESTABLISHMENT OF THE FLOATING RATE SENIOR NOTES; TERMS
	  	 	3	  

							
	 SECTION 201
	  	 Establishment and Designation of the Floating Rate Senior Notes
	  	 	3	  
	 SECTION 202
	  	 Form of the Floating Rate Senior Notes
	  	 	3	  
	 SECTION 203
	  	 Principal Amount of the Floating Rate Senior Notes
	  	 	3	  
	 SECTION 204
	  	 Interest Rates; Stated Maturity of the Floating Rate Senior Notes
	  	 	3	  
	 SECTION 205
	  	 No Sinking Fund
	  	 	3	  
	 SECTION 206
	  	 No Redemption
	  	 	3	  
	 SECTION 207
	  	 Paying Agent and Bond Registrar
	  	 	3	  
	 SECTION 208
	  	 Calculation Agent
	  	 	4	  
	 SECTION 209
	  	 Global Securities; Appointment of Depositary for Global Securities
	  	 	4	  
	 SECTION 210
	  	 Other Terms of the Floating Rate Senior Notes
	  	 	4	  

							
	 ARTICLE III
	  	MISCELLANEOUS 	  	 	4	  

							
	 SECTION 301
	  	 Concerning the Trustee
	  	 	4	  
	 SECTION 302
	  	 Application of Twenty-Second Supplemental Indenture
	  	 	5	  
	 SECTION 303
	  	 Effective Date of Twenty-Second Supplemental Indenture
	  	 	5	  
	 SECTION 304
	  	 Counterparts
	  	 	5	  

					
	 EXHIBIT A
	  		  	

  
 i 

 TWENTY-SECOND SUPPLEMENTAL INDENTURE, dated as of May 12, 2014 (this
“Twenty-Second Supplemental Indenture”), by and between PACIFIC GAS AND ELECTRIC COMPANY, a corporation duly organized and existing under the laws of the State of California (the “Company” or the “Issuer”), and
THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A., a national banking association organized and existing under the laws of the United States of America (formerly known as The Bank of New York Trust Company, N.A.), as Trustee under the Base
Indenture (as hereinafter defined) (the “Trustee”). 
 RECITALS OF THE COMPANY 

A.    The Company and the Trustee are parties to that certain Amended and Restated Indenture, dated as of April 22,
2005 (the “Base Indenture”), as supplemented by the First Supplemental Indenture, dated as of March 13, 2007 (the “First Supplemental Indenture”), the Second Supplemental Indenture, dated as of December 4, 2007 (the
“Second Supplemental Indenture”), the Third Supplemental Indenture, dated as of March 3, 2008 (the “Third Supplemental Indenture”), the Fourth Supplemental Indenture, dated as of October 21, 2008 (the “Fourth
Supplemental Indenture”), the Fifth Supplemental Indenture, dated as of November 18, 2008 (the “Fifth Supplemental Indenture”), the Sixth Supplemental Indenture, dated as of March 6, 2009 (the “Sixth Supplemental
Indenture”), the Seventh Supplemental Indenture, dated as of June 11, 2009 (the “Seventh Supplemental Indenture”), the Eighth Supplemental Indenture, dated as of November 18, 2009 (the “Eighth Supplemental
Indenture”), the Ninth Supplemental Indenture, dated as of April 1, 2010 (the “Ninth Supplemental Indenture”), the Tenth Supplemental Indenture, dated as of September 15, 2010 (the “Tenth Supplemental Indenture”),
the Eleventh Supplemental Indenture, dated as of October 12, 2010 (the “Eleventh Supplemental Indenture”), the Twelfth Supplemental Indenture, dated as of November 18, 2010 (the “Twelfth Supplemental Indenture”), the
Thirteenth Supplemental Indenture, dated as of May 13, 2011 (the “Thirteenth Supplemental Indenture”), the Fourteenth Supplemental Indenture, dated as of September 12, 2011 (the “Fourteenth Supplemental Indenture”), the
Fifteenth Supplemental Indenture, dated as of November 22, 2011 (the “Fifteenth Supplemental Indenture”), the Sixteenth Supplemental Indenture, dated as of December 1, 2011 (the “Sixteenth Supplemental Indenture”), the
Seventeenth Supplemental Indenture, dated as of April 16, 2012 (the “Seventeenth Supplemental Indenture”), the Eighteenth Supplemental Indenture, dated as of August 16, 2012 (the “Eighteenth Supplemental Indenture”),
the Nineteenth Supplemental Indenture, dated as of June 14, 2013 (the “Nineteenth Supplemental Indenture”), the Twentieth Supplemental Indenture, dated as of November 12, 2013 (the “Twentieth Supplemental Indenture”),
the Twenty-First Supplemental Indenture, dated as of February 21, 2014 (the “Twenty-First Supplemental Indenture”), and this Twenty-Second Supplemental Indenture (this “Twenty-Second Supplemental Indenture,” and together
with the Base Indenture, the First Supplemental Indenture, the Second Supplemental Indenture, the Third Supplemental Indenture, the Fourth Supplemental Indenture, the Fifth Supplemental Indenture, the Sixth Supplemental Indenture, the Seventh
Supplemental Indenture, the Eighth Supplemental Indenture, the Ninth Supplemental Indenture, the Tenth Supplemental Indenture, the Eleventh Supplemental Indenture, the Twelfth Supplemental Indenture, the Thirteenth Supplemental Indenture, the
Fourteenth Supplemental Indenture, the Fifteenth Supplemental Indenture, the Sixteenth Supplemental Indenture, the Seventeenth Supplemental Indenture, the Eighteenth Supplemental Indenture, the Nineteenth Supplemental Indenture, the Twentieth
Supplemental Indenture and the Twenty-First Supplemental Indenture, the “Indenture”), which supplements, amends and 

 
restates that certain Indenture of Mortgage, dated as of March 11, 2004, as supplemented by the First Supplemental Indenture thereto, dated as of March 23, 2004 and the Second
Supplemental Indenture thereto, dated as of April 12, 2004, providing for the issuance by the Company of an unlimited number of series of Bonds (as defined in the Base Indenture) from time to time. 

B.    Under the Base Indenture, the Company is authorized to establish one or more series of Bonds at any time in
accordance with and subject to the provisions of the Base Indenture, and the terms of such series of Bonds may be described by a supplemental indenture executed by the Company and the Trustee. 

C.    The execution and delivery of this Twenty-Second Supplemental Indenture has been authorized by a Board Resolution (as
defined in the Base Indenture). 
 D.    Concurrent with the execution hereof, the Company has caused its counsel to
deliver to the Trustee an Opinion of Counsel (as defined in the Base Indenture) pursuant to Section 13.03 of the Base Indenture, together with the documents required under Article V of the Base Indenture. 

E.    The Company has done all things necessary to make this Twenty-Second Supplemental Indenture a valid agreement of the
Company, in accordance with its terms. 
 NOW, THEREFORE, the Company and the Trustee agree, for the benefit of each other and for the equal
and proportionate benefit of Holders of the Floating Rate Senior Notes (as defined below) with respect to all provisions herein applicable to such series of notes, as follows: 

ARTICLE I 
 
DEFINITIONS 
 Unless the context otherwise requires, capitalized terms used but not defined herein have the meaning set forth in
the Indenture. The following additional terms are hereby established for purposes of this Twenty-Second Supplemental Indenture and shall have the meanings set forth in this Twenty-Second Supplemental Indenture only for purposes of this Twenty-Second
Supplemental Indenture: 
 “Calculation Agency Agreement” means the Calculation Agency Agreement, dated as of
May 12, 2014, by and between the Company and the Calculation Agent, as such agreement may be amended, modified or supplemented from time to time. 

“Calculation Agent” means The Bank of New York Mellon Trust Company, N.A. or such other Person as the Company shall
from time to time designate in accordance with the Calculation Agency Agreement. 
 “Floating Rate Senior Notes” has
the meaning set forth in Section 201 hereto. 
 “Original Issue Date” means May 12, 2014. 

 
  

  
 2 

 The words “herein,” “hereof” and “hereunder” and other words of
similar import refer to this Twenty-Second Supplemental Indenture as a whole and not to any particular Article, Section or other subdivision. 

ARTICLE II 
 
ESTABLISHMENT OF THE FLOATING RATE SENIOR NOTES; TERMS 
 SECTION
201    Establishment and Designation of the Floating Rate Senior Notes. 

Pursuant to the terms hereof and Section 3.01 of the Indenture, the Company hereby establishes a forty-fifth series of Bonds designated as
the “Floating Rate Senior Notes due May 11, 2015” (the “Floating Rate Senior Notes”). The Floating Rate Senior Notes may be reopened, from time to time, for issuances of additional Bonds of such series, and any additional
Bonds issued and comprising Floating Rate Senior Notes shall have identical terms as the Floating Rate Senior Notes, except that the issue price, issue date and, in some cases, the first Interest Payment Date may differ. 

SECTION 202    Form of the Floating Rate Senior Notes. 

The Floating Rate Senior Notes shall be issued in the form of one or more Global Bonds in substantially the form set forth in Exhibit A
hereto. 
 SECTION 203    Principal Amount of the Floating Rate Senior
Notes. 
 The Floating Rate Senior Notes shall be issued in an initial aggregate principal amount of $300,000,000. 

SECTION 204    Interest Rates; Stated Maturity of the Floating Rate Senior
Notes. 
 The rate of interest on the Floating Rate Senior Notes shall be calculated as set forth in the form of the Floating Rate
Senior Notes attached as Exhibit A hereto. 
 The Floating Rate Senior Notes shall have a Stated Maturity of May 11, 2015. 

SECTION 205    No Sinking Fund. 

No sinking fund is provided for the Floating Rate Senior Notes. 

SECTION 206    No Redemption. 

The Floating Rate Senior Notes shall not be subject to redemption prior to their Stated Maturity. 

SECTION 207    Paying Agent and Bond Registrar. 

The Trustee is hereby appointed as initial Paying Agent and initial Bond Registrar for the Floating Rate Senior Notes. The Place of Payment of
the Floating Rate Senior Notes shall be the Corporate Trust Office of the Trustee. 

  
 3 

 SECTION 208    Calculation
Agent. 
 The Bank of New York Mellon Trust Company, N.A. is hereby appointed as the initial Calculation Agent for the Floating Rate
Senior Notes. 
 SECTION 209    Global Securities; Appointment of Depositary for
Global Securities. 
 The Floating Rate Senior Notes shall be issued in the form of one or more permanent Global Bonds as
provided in Section 3.13 of the Indenture and deposited with, or on behalf of, the Depositary, or with the Trustee, as custodian for the Depositary, duly executed by the Company and authenticated by the Trustee. 

The Company hereby initially appoints The Depository Trust Company (“DTC”) to act as the Depositary with respect to all Floating
Rate Senior Notes, and the Floating Rate Senior Notes shall initially be registered in the name of Cede & Co., as the nominee of DTC. 

The Company and DTC have executed a Blanket Letter of Representations, and the Trustee is hereby authorized, in connection with any successor
nominee for DTC or any successor Depositary, to enter into appropriate or comparable arrangements, if necessary, and shall have the same rights with respect to its actions thereunder as it has with respect to its actions under the Indenture. 

None of the Company, the Trustee, any Paying Agent or any Bond Registrar will have any responsibility or liability for any aspect of
Depositary records relating to, or payments made on account of, beneficial ownership interests in a Global Bond or for maintaining, supervising or reviewing any Depositary records relating to such beneficial ownership interests, or for transfers of
beneficial interests in the Bonds or any transactions between the Depositary and beneficial owners. 
 SECTION
210    Other Terms of the Floating Rate Senior Notes. 
 The other terms of
the Floating Rate Senior Notes shall be as expressly set forth herein and in Exhibit A. 
 ARTICLE III 

MISCELLANEOUS 

SECTION 301    Concerning the Trustee. 

In acting under and by virtue of this Twenty-Second Supplemental Indenture, the Trustee shall have all of the rights, protections and
immunities given to it in the Base Indenture. The Trustee shall have no responsibility for the validity or sufficiency of this Twenty-Second Supplemental Indenture. 

  
 4 

 SECTION 302    Application of
Twenty-Second Supplemental Indenture. 
 Except as provided herein, each and every term and condition contained in this Twenty-Second
Supplemental Indenture that modifies, amends or supplements the terms and conditions of the Indenture shall apply only to the Floating Rate Senior Notes established hereby and not to any other series of Bonds established under the Indenture. Except
as specifically amended and supplemented by, or to the extent inconsistent with, this Twenty-Second Supplemental Indenture, the Indenture shall remain in full force and effect and is hereby ratified and confirmed. 

SECTION 303    Effective Date of Twenty-Second Supplemental Indenture. 

This Twenty-Second Supplemental Indenture shall be effective upon the execution and delivery hereof by each of the parties hereto. 

SECTION 304    Counterparts. 

This Twenty-Second Supplemental Indenture may be executed in any number of counterparts, each of which so executed shall be deemed to be an
original, but all such counterparts shall together constitute but one and the same instrument. 

  
 5 

 IN WITNESS WHEREOF, the parties hereto have caused this Twenty-Second Supplemental Indenture to
be duly executed by their respective officers hereunto duly authorized, all as of the day and year first above written. 
  

			
	 PACIFIC GAS AND ELECTRIC COMPANY,

           as Issuer

		
	By:	 	/s/ Nicholas M. Bijur
	Name:	 	Nicholas M. Bijur
	Title:	 	Vice President and Treasurer

  

			
	 THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A.,

           as Trustee

		
	By:	 	/s/ Melonee Young
	Name:	 	Melonee Young
	Title:	 	Vice President

 Signature Page to Twenty-Second Supplemental Indenture 

 EXHIBIT A 

FORM OF FLOATING RATE SENIOR NOTES DUE MAY 11, 2015 

THIS SENIOR NOTE IS A BOND AND A GLOBAL BOND WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A
DEPOSITARY OR A NOMINEE THEREOF. UNLESS AND UNTIL IT IS EXCHANGED IN WHOLE OR IN PART FOR SENIOR NOTES IN DEFINITIVE FORM, THIS SENIOR NOTE MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE DEPOSITARY TO A NOMINEE OF THE DEPOSITARY OR BY A NOMINEE OF
THE DEPOSITARY TO THE DEPOSITARY OR ANOTHER NOMINEE OF THE DEPOSITARY OR BY THE DEPOSITARY OR ANY SUCH NOMINEE TO A SUCCESSOR DEPOSITARY OR A NOMINEE OF SUCH SUCCESSOR DEPOSITARY. 

UNLESS THIS SENIOR NOTE CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION
(“DTC”), TO THE COMPANY OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY SENIOR NOTE CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED
REPRESENTATIVE OF DTC (AND ANY PAYMENT IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL
INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN. 
 THE FOLLOWING SUMMARY OF TERMS IS SUBJECT TO THE
INFORMATION SET FORTH ON THE REVERSE HEREOF: 
  

					
	 PRINCIPAL AMOUNT :

$300,000,000
	 	 ORIGINAL ISSUE DATE:
 May 12,
2014
	 	INTEREST RATE: 3-month LIBOR plus 0.20% per annum
			
	 MATURITY DATE:

May 11, 2015
	 	 INTEREST PAYMENT DATES:
 August 11,
2014, November 11, 2014, February 11, 2015 and the Maturity Date
	 	 THIS SENIOR NOTE IS A:
 x Global Book-Entry Bond
  ̈ Certificated Bond

			
	REGISTERED OWNER: Cede & Co., as nominee of The Depository Trust Company	 		 	

  
 A-1 

 PACIFIC GAS AND ELECTRIC COMPANY 

FLOATING RATE SENIOR NOTES DUE MAY 11, 2015 

(Floating Rate) 
  

			
	No. R-1	 	Principal Amount: $300,000,000
	CUSIP No: 694308 HJ9	 	

 PACIFIC GAS AND ELECTRIC COMPANY, a corporation duly organized and existing under the laws of the State of
California (herein called the “Company,” which term includes any successor Person pursuant to the applicable provisions of the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede & Co., as
nominee for The Depository Trust Company, or registered assigns, the Principal Amount stated above on the Maturity Date stated above, and to pay interest thereon from and including the Original Issue Date stated above or, in the case of a Floating
Rate Senior Note due May 11, 2015 issued upon the registration of transfer or exchange, from and including the most recent Interest Payment Date to which interest has been paid or duly provided for, quarterly in arrears on the Interest Payment
Dates set forth above and on the Maturity Date stated above until the principal hereof is paid or made available for payment. The interest so payable, and punctually paid or duly provided for, on any Interest Payment Date will, as provided in such
Indenture, be paid to the Person in whose name this Floating Rate Senior Note due May 11, 2015 (this “Senior Note,” and together with all other Floating Rate Senior Notes due May 11, 2015, the “Senior Notes”) (or one or
more Predecessor Bonds) is registered at the close of business on the Regular Record Date for such interest, which shall be the 15th day preceding such Interest Payment Date; provided, however, that interest payable at the Maturity
Date will be paid to the Person to whom principal is payable. Any such interest not so punctually paid or duly provided for will forthwith cease to be payable to the Holder on such Regular Record Date and may either be paid to the Person in whose
name this Senior Note (or one or more Predecessor Bonds) is registered at the close of business on a Special Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of Senior Notes
not less than 10 days prior to such Special Record Date, or be paid at any time in any other lawful manner not inconsistent with the requirements of the Indenture and any securities exchange, if any, on which the Senior Notes may be listed, and upon
such notice as may be required by any such exchange, all as more fully provided in said Indenture. 
 Payments of interest on this Senior
Note will include interest accrued to but excluding the respective Interest Payment Dates. Interest payments for this Senior Note shall be computed and paid on the basis of a 360-day year and the actual days elapsed. 

Payment of principal of, premium, if any, and interest on Senior Notes shall be made in such coin or currency of the United States of America
as at the time of payment is legal tender for payment of public and private debts. Payments of principal of, premium, if any, and interest on the Senior Notes represented by a Global Bond shall be made by wire transfer of immediately available funds
to the Holder of such Global Bond, provided that, in the case of payments of 

  
 A-2 

 
principal and premium, if any, such Global Bond is first surrendered to the Paying Agent. If any of the Senior Notes are no longer represented by a Global Bond, (i) payments of principal,
premium, if any, and interest due on the Maturity Date of such Senior Notes shall be made at the office of the Paying Agent upon surrender of such Senior Notes to the Paying Agent, and (ii) payments of interest shall be made, at the option of
the Company, subject to such surrender where applicable, (A) by check mailed to the address of the Person entitled thereto as such address shall appear in the Bond Register or (B) by wire transfer to registered Holders of at least
$10,000,000 in principal amount of Senior Notes at such place and to such account at a banking institution in the United States as such Holders may designate in writing to the Trustee at least sixteen (16) days prior to the date for payment.

 REFERENCE IS HEREBY MADE TO THE FURTHER PROVISIONS OF THIS SENIOR NOTE SET FORTH ON THE REVERSE HEREOF, WHICH FURTHER PROVISIONS SHALL
FOR ALL PURPOSES HAVE THE SAME EFFECT AS IF SET FORTH AT THIS PLACE. 
 Unless the certificate of authentication hereon has been executed by
the Trustee referred to on the reverse hereof by manual signature, this Senior Note shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose. 

  
 A-3 

 IN WITNESS WHEREOF, the Company has caused this instrument to be
duly executed. 
 Dated: May         , 2014 

 

			
	PACIFIC GAS AND ELECTRIC COMPANY
		
	By:	 	 
	Name:	 	Kent M. Harvey
	Title:	 	Senior Vice President, Financial Services

  

			
		
	By:	 	 
	Name:	 	Nicholas M. Bijur
	Title:	 	Vice President and Treasurer

  
 A-4 

 TRUSTEE’S CERTIFICATE OF AUTHENTICATION 

This Senior Note is one of the Bonds of the series designated as Bonds of the Forty-Fifth Series referred to in the within-mentioned
Indenture. 
 Dated: May         , 2014 

 

			
	THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A., As Trustee
		
	By:	 	 
		 	Authorized Signatory

  
 A-5 

 Reverse of Senior Note 

This Floating Rate Senior Note due May 11, 2015 is one of a duly authorized issue of Bonds of the Company, issued and issuable in one or
more series under an Amended and Restated Indenture, dated as of April 22, 2005 (the “Base Indenture”), as heretofore supplemented and as further supplemented by a Twenty-Second Supplemental Indenture, dated as of May 12, 2014
(as so supplemented, and together with all additional indentures supplemental thereto, and any constituent instruments establishing the terms of particular Bonds, being herein called the “Indenture”), between the Company and The Bank of
New York Mellon Trust Company, N.A. (formerly The Bank of New York Trust Company, N.A.), as Trustee (herein called the “Trustee,” which term includes any successor trustee under the Indenture), and reference is hereby made to the Indenture
for a description of the respective rights, limitations of rights, duties and immunities of the Company, the Trustee and the Holders of Bonds thereunder and of the terms and conditions upon which Bonds are, and are to be, authenticated and
delivered. This Senior Note is a Bond within the meaning of the Indenture and is one of the Bonds of the forty-fifth series designated as the Floating Rate Senior Note due May 11, 2015 established by the Company under the Indenture. The
acceptance of this Senior Note shall be deemed to constitute the consent and agreement by the Holder hereof to all of the terms and provisions of the Indenture. 

The interest rate on the Senior Notes will be reset quarterly on August 11, 2014, November 11, 2014 and February 11, 2015
(each, an “Interest Reset Date”). The Senior Notes will bear interest at a per annum rate equal to three-month LIBOR (as defined below) for the applicable Interest Reset Period or Initial Interest Period (each as defined below) plus 0.20%
(20 basis points). The interest rate for the Initial Interest Period will be three-month LIBOR, determined as of two London Business Days prior to the Original Issue Date, plus 0.20% (20 basis points) per annum, which shall be 0.42335%. 

The “Initial Interest Period” will be the period from and including the Original Issue Date to but excluding the initial Interest
Reset Date. Thereafter, each “Interest Reset Period” will be the period from and including an Interest Reset Date to but excluding the immediately succeeding Interest Reset Date; provided that the final Interest Reset Period for the Senior
Notes will be the period from and including the Interest Reset Date immediately preceding the Maturity Date of such Senior Notes to but excluding the Maturity Date. 

If any Interest Reset Date would otherwise be a day that is not a Business Day, the Interest Reset Date will be postponed to the immediately
succeeding day that is a Business Day, except that if that Business Day is in the immediately succeeding calendar month, the Interest Reset Date shall be the immediately preceding Business Day. 

The interest rate in effect on each day will be (i) if that day is an Interest Reset Date, the interest rate determined as of the
Interest Determination Date (as defined below) immediately preceding such Interest Reset Date or (ii) if that day is not an Interest Reset Date, the interest rate determined as of the Interest Determination Date immediately preceding the most
recent Interest Reset Date or the Original Issue Date, as the case may be. 

  
 A-6 

 The interest rate applicable to each Interest Reset Period commencing on the related Interest
Reset Date, or the Original Issue Date in the case of the Initial Interest Period, will be the rate determined as of the applicable Interest Determination Date. The “Interest Determination Date” will be the second London Business Day
immediately preceding the Original Issue Date, in the case of the initial Interest Reset Period, or thereafter, will be the second London Business Day immediately preceding the applicable Interest Reset Date. With respect to any Interest
Determination Date, the Calculation Agent will determine three-month LIBOR in accordance with the following provisions: 
 (i) LIBOR is the
rate for deposits in U.S. dollars for the 3-month period which appears on Reuters Screen LIBOR01 Page (as defined below) at approximately 11:00 a.m., London time, on the applicable Interest Determination Date. “Reuters Screen LIBOR01 Page”
means the display designated on page “LIBOR01” on Reuters Screen (or such other page as may replace the LIBOR01 page on that service, any successor service or such other service or services as may be nominated by the British Bankers’
Association for the purpose of displaying London interbank offered rates for U.S. dollar deposits). If no rate appears on Reuters Screen LIBOR01 Page, LIBOR for such Interest Determination Date will be determined in accordance with the provisions of
paragraph (ii) below. 
 (ii) With respect to an Interest Determination Date on which no rate appears on Reuters Screen LIBOR01 Page as
of approximately 11:00 a.m., London time, on such Interest Determination Date, the Calculation Agent shall request the principal London offices of each of four major reference banks (which may include affiliates of the underwriters) in the London
interbank market selected by the Company to provide the Calculation Agent with a quotation of the rate at which deposits of U.S. dollars having a three-month maturity, commencing on the second London Business Day immediately following such Interest
Determination Date, are offered by it to prime banks in the London interbank market as of approximately 11:00 a.m., London time, on such Interest Determination Date in a principal amount equal to an amount of not less than U.S. $1,000,000 that is
representative for a single transaction in such market at such time. If at least two such quotations are provided, LIBOR for such Interest Determination Date will be the arithmetic mean of such quotations as calculated by the Calculation Agent. If
fewer than two quotations are provided, LIBOR for such Interest Determination Date will be the arithmetic mean of the rates quoted as of approximately 11:00 a.m., New York City time, on such Interest Determination Date by three major banks (which
may include affiliates of the underwriters) selected by the Company for loans in U.S. dollars to leading European banks having a three-month maturity commencing on the second London Business Day immediately following such Interest Determination Date
and in a principal amount equal to an amount of not less than U.S. $1,000,000 that is representative for a single transaction in such market at such time; provided, however, that if the banks selected as aforesaid by the Company are not quoting such
rates as mentioned in this sentence, LIBOR for such Interest Determination Date will be LIBOR determined with respect to the immediately preceding Interest Determination Date. 

All percentages resulting from any calculation of any interest rate for the Senior Notes will be rounded, if necessary, to the nearest one
hundred thousandth of a percentage point, with five one-millionths of a percentage point rounded upward (e.g., 9.876545% (or .09876545) would be rounded to 9.87655% (or .0987655)), and all dollar amounts will be rounded to the nearest cent, with
one-half cent being rounded upward. 

  
 A-7 

 Promptly upon such determination, the Calculation Agent will notify the Company and the Trustee
(if the Calculation Agent is not the Trustee) of the interest rate for the new Interest Reset Period. Upon request of a Holder of the Senior Notes, the Calculation Agent will provide to such Holder the interest rate in effect on the date of such
request and, if determined, the interest rate for the next Interest Reset Period. 
 All calculations made by the Calculation Agent for the
purposes of calculating interest on the Senior Notes shall be conclusive and binding on the Holders of the Senior Notes and the Company, absent manifest errors. 

“Business Day” means any day (1) that is not a Saturday or Sunday and that is not a day on which banking institutions are
authorized or obligated by law or executive order to close in The City of New York and, for any place of payment outside of The City of New York, in such place of payment, and (2) that is also a “London Business Day”, which is a day
on which dealings in deposits in U.S. dollars are transacted in the London interbank market. 
 Interest will be payable on August 11,
2014, November 11, 2014 and February 11, 2015, and on the Maturity Date (each an “Interest Payment Date”). In the event that any date on which interest is payable on this Senior Note (other than the Maturity Date) is not a
Business Day, then payment of the interest payable on such date will be made on the next succeeding day that is a Business Day (and without any interest or payment in respect of any such delay) with the same force and effect as if made on the date
the payment was originally payable, except that if such Business Day is in the next succeeding calendar month, such Interest Payment Date shall be the immediately preceding Business Day. If the Maturity Date falls on a day that is not a Business
Day, the payment of principal, premium, if any, and interest may be made on the next succeeding Business Day with the same force and effect as if made on the date payment was originally payable, and no interest on such payment shall accrue for the
period from and after maturity. 
 Unless otherwise specified on the face hereof, interest payments, if any, will be the amount of interest
accrued from and including the last date in respect of which interest has been paid or duly provided for (or from and including the Original Issue Date stated above if no interest has been paid or provided for with respect to this Senior Note) to
but excluding the Interest Payment Date or the Maturity Date. Accrued interest hereon from the Original Issue Date stated above or from the last date to which interest hereon has been paid is calculated by multiplying the face amount hereof by an
accrued interest factor. Such accrued interest factor is computed by adding the interest factor calculated for each day from the Original Issue Date stated above or from the last date to which interest shall have been paid, to the date for which
accrued interest is being calculated. The interest factor for each day shall be computed by dividing the interest rate applicable to such day by 360. All percentages resulting from any calculation hereon will be rounded to the nearest one
hundred-thousandth of a percentage point, with five-one millionths of a percentage point rounded upwards. For example, 9.876545% (or .09876545) would be rounded to 9.87655% (or .0987655). All dollar amounts used in or resulting from any calculation
hereon will be rounded to the nearest cent. 
 The interest rate on the Senior Notes will in no event be higher than the maximum rate
permitted by California law as the same may be modified by United States law of general applicability. 

  
 A-8 

 This Senior Note shall not be subject to redemption prior to its Stated Maturity. 

As provided in the Indenture and subject to certain limitations therein set forth, this Senior Note or any portion of the principal amount
hereof will be deemed to have been paid for all purposes of the Indenture and to be no longer Outstanding thereunder, and the Company’s entire indebtedness in respect thereof will be satisfied and discharged, if there has been irrevocably
deposited with the Trustee or any Paying Agent (other than the Company), in trust, money in an amount which will be sufficient and/or Eligible Obligations, the principal of and interest on which when due, without regard to any reinvestment thereof,
will provide moneys which, together with money, if any, deposited with or held by the Trustee or such Paying Agent, will be sufficient to pay when due the principal of and premium, if any, and interest on this Senior Note when due. 

If an Event of Default shall occur and be continuing, the Trustee or the Holders of not less than 33% in aggregate principal amount of the
Outstanding Bonds, considered as one class, may declare the principal amount of all Bonds then Outstanding to be due and payable immediately by notice in writing to the Company (and to the Trustee if given by Holders); provided, however, that with
respect to certain Events of Default relating to bankruptcy, insolvency and similar events, the principal amount of all Bonds then Outstanding shall be due and payable immediately without further action by the Trustee or the Holders. 

The Indenture permits, with certain exceptions as therein provided, the Company and the Trustee to enter into one or more supplemental
indentures for the purpose of adding any provisions to, or changing in any manner or eliminating any of the provisions of, the Indenture with the consent of the Holders of not less than a majority in aggregate principal amount of the Bonds at the
time Outstanding, considered as one class; provided, however, that if there shall be Bonds of more than one series Outstanding under the Indenture and if a proposed supplemental indenture shall directly affect the rights of the Holders of Bonds of
one or more, but less than all, of such series, then the consent only of the Holders of a majority in aggregate principal amount of the Outstanding Bonds of all series so directly affected, considered as one class, shall be required; and provided,
further, that if the Bonds of any series shall have been issued in more than one Tranche and if a proposed supplemental indenture shall directly affect the rights of the Holders of Bonds of one or more, but less than all, of such Tranches, then the
consent only of the Holders of a majority in aggregate principal amount of the Outstanding Bonds of all Tranches so directly affected, considered as one class, shall be required; and provided, further, that the Indenture permits the Company and the
Trustee to enter into one or more supplemental indentures for certain purposes without the consent of any Holders of Bonds. The Indenture also contains provisions permitting the Holders of a majority in aggregate principal amount of Bonds, on behalf
of the Holders of all such Bonds, to waive certain past defaults under the Indenture and their consequences. Any such consent or waiver by the Holder of this Senior Note shall be conclusive and binding upon such Holder and upon all future Holders of
this Senior Note and of any Senior Note issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation of such consent or waiver is made upon this Senior Note. 

As provided in and subject to the provisions of the Indenture, the Holder of this Senior Note shall not have the right to institute any
proceeding with respect to the Indenture or for the appointment of a receiver or trustee or for any other remedy thereunder, unless such Holder shall 

  
 A-9 

 
have previously given the Trustee written notice of a continuing Event of Default, the Holders of at least 33% in aggregate principal amount of the Bonds at the time Outstanding shall have made
written request to the Trustee to institute proceedings in respect of such Event of Default as Trustee and offered the Trustee reasonable indemnity, and the Trustee shall not have received from the Holders of at least a majority in aggregate
principal amount of Bonds at the time Outstanding a direction inconsistent with such written request, and shall have failed to institute any such proceeding for 60 days after receipt of such notice, request and offer of indemnity. The foregoing
shall not apply to any suit instituted by the Holder of this Senior Note for the enforcement of any payment of principal hereof or any premium or interest hereon on or after the respective due dates expressed herein. 

No reference herein to the Indenture and no provision of this Senior Note or of the Indenture shall alter or impair the obligation of the
Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Senior Note at the times, place and rate, and in the coin or currency, herein prescribed. 

As provided in the Indenture and subject to certain limitations therein set forth, the transfer of this Senior Note is registrable in the Bond
Register, upon surrender of this Senior Note for registration of transfer at the office or agency of the Company in any place where the principal of and any premium and interest on this Senior Note are payable, duly endorsed by, or accompanied by a
written instrument of transfer in form satisfactory to the Company, the Trustee or the Bond Registrar, as the case may be, duly executed by the Holder hereof or such Holder’s attorney duly authorized in writing, and thereupon one or more new
Senior Notes of like tenor, of authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees. 

The Senior Notes are issuable only in registered form without coupons in denominations of $2,000 and integral multiples of $1,000 in excess
thereof. As provided in the Indenture and subject to certain limitations therein set forth, Senior Notes are exchangeable for a like aggregate principal amount of Senior Notes and of like tenor of a different authorized denomination, as requested by
the Holder surrendering the same. 
 No service charge shall be made for any such registration of transfer or exchange, but the Company may
require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. 
 Prior to due
presentment of this Senior Note for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee may treat the Person in whose name this Senior Note is registered as the owner hereof for all purposes, whether or not
this Senior Note is overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary. 
 This
Senior Note shall be governed by, and construed and enforced in accordance with, the laws of the State of California without regard to the principles of conflicts of laws thereunder, except to the extent that the Trust Indenture Act shall be
applicable. 

  
 A-10 

 As provided in the Indenture, no recourse shall be had for the payment of the principal of,
premium, if any, or interest with respect to this Senior Note, or any part thereof, or for any claim based hereon or otherwise in respect hereof, or of the indebtedness represented hereby, or upon any obligation, covenant or agreement under the
Indenture, against any incorporator, shareholder, officer or director, as such, past, present or future, of the Company or of any predecessor or successor corporation (either directly or through the Company or a predecessor or successor
corporation), whether by virtue of any constitutional provision, statute or rule of law or by the enforcement of any assessment or penalty or otherwise; it being expressly agreed and understood that the Indenture and all the Bonds are solely
corporate obligations and that any such personal liability is hereby expressly waived and released as a condition of, and as part of the consideration for, the execution of the Indenture and the issuance of this Senior Note. 

All terms used in this Senior Note which are not defined herein shall have the meanings assigned to them in the Indenture. 

  
 A-11 

 ASSIGNMENT FORM 

To assign this Senior Note, fill in the form below: (I) or (we) assign and transfer this Senior Note to 

 
  

(Insert assignee’s soc. sec. or tax I.D. no.) 
  

 
  

 
  

 
  

 
  

 
 (Print or type assignee’s name, address and zip
code) 
  
  

and irrevocably
appoint                                        
                                         
                                         
                                         
               
 to transfer this Senior Note on the books of the Company. The
agent may substitute another to act for him. 
  
  

Date:
                             

 

			
	
Your signature:                     
                                         
                               

	(Sign exactly as your name appears on the face of this Senior Note)
	
	Tax Identification No.:                              
                                         
          
	
	 SIGNATURE GUARANTEE:

		
	  
	 	
	
	Signatures must be guaranteed by an “eligible guarantor institution” meeting the requirements of the Bond Registrar, which requirements include membership or participation in the Securities Transfer Agent
Medallion Program (“STAMP”) or such other “signature guarantee program” as may be determined by the Bond Registrar in addition to, or in substitution for, STAMP, all in accordance with the Securities Exchange Act of 1934,
as amended.

  
 A-12EX-10.1

 Exhibit 10.1 

CONSULTING AND GENERAL RELEASE AGREEMENT 

This CONSULTING AND GENERAL RELEASE AGREEMENT (the “Consulting Agreement”) is made and entered into between Quintiles Transnational
Corp. (the “Company”) and Michael Mortimer (the “Executive” or “Consultant” or “Executive/Consultant”). Throughout the remainder of the Consulting Agreement, the Company and Executive or Consultant may be
collectively referred to as “the parties.” 
 Executive is currently employed under an Executive Employment Agreement with the
Company, dated June 1, 2003, as amended on January 9, 2004 and December 30, 2008 (the “Employment Agreement”), and currently serves as its Executive Vice President, Human Resources and Corporate Administration. Executive is
resigning from his officer position as Executive Vice President, Human Resources and Corporate Administration, effective immediately, and from his employment as of June 30, 2014. The Company wishes to retain Executive’s services following
his resignation, and the parties have agreed to the terms for a consulting arrangement, as set forth herein, which shall continue until December 31, 2014. The parties agree that, for all purposes, the Executive shall be deemed to have
retired from the Company as of December 31, 2014. The parties have negotiated the terms of Executive’s termination from employment and of the consulting arrangement, and have agreed upon acceptable terms as described herein. 

Executive represents that he has carefully read this entire Consulting Agreement, understands its consequences, and voluntarily enters into
it. 
 In consideration of the above and the mutual promises set forth below, the Executive and the Company agree as follows: 

1. RESIGNATION, SEPARATION AND RETIREMENT. Executive herby resigns from all officer positions with the Company and its
subsidiaries and affiliates (including Quintiles Transnational Holdings Inc.), effective immediately, and from his employment with the Company, as of June 30, 2014 (“Employment Termination Date”). Until the Employment Termination
Date, Executive shall perform such duties and special projects as he is assigned by the Company (provided that such duties and special projects are reasonably related to his former position as Executive Vice President, Human Resources and Corporate
Administration), and Executive shall be paid and receive all of his regular existing compensation and benefits through such date (including but not limited to reimbursement for all business expenses incurred on or prior to the Employment Termination
Date). Executive acknowledges and agrees that he will not receive the severance pay and benefits set forth in Sections 5.2 and 5.3 of the Employment Agreement, and the parties acknowledge and agree that, for all purposes, the Executive shall be
deemed to have retired from the Company as of December 31, 2014. 
 2. POST TERMINATION BONUS AND BENEFITS. 

(a) Bonus. The Company shall pay Executive in lump sum $350,000 as a bonus for the 2014 performance year, less applicable
withholdings; provided, however, that if the Company does not pay out to other participants in the Management Incentive Plan (“MIP”) at least 100% of the MIP bonus pool 

 
for 2014, then the amount due Executive under this Section 2 shall be reduced by the same percentage that the Company’s payout of the MIP bonus pool is below 100%. Such payment shall be
made in 2015 on the same date as the other senior executives participating in the MIP receive their bonus payment for 2014, but in no event shall such payment be made after February 28, 2015, provided that the releases of claims set forth in
Section 7 of this Consulting Agreement are effective and no longer subject to revocation. 
 (b) Benefits. After the
Employment Termination Date, except as provided in Sections 2(a), 3(b) and 3(d), Executive shall not be entitled to disability, accidental death or any other employee benefits, and shall not be a participant in the Company’s 401(k) Plan (the
“401(k) Plan”) or any other plan of any type. For the avoidance of doubt, Executive will not be eligible to contribute to his 401(k) plan from any post termination payments under this Section 2 or from the Consulting Fee under
Section 3, nor receive matching funds from the Company’s related policies. Nothing in this Consulting Agreement, however, shall be deemed to limit Executive’s continuation coverage rights under COBRA or Executive’s vested rights,
if any, under the 401(k) Plan or other plans, and the terms of those plans shall govern. 
 3. CONSULTING SERVICES, CONSULTING
TERM. 
 (a) Term and Nature of Services. Beginning on the Employment Termination Date and continuing through
December 31, 2014 (the “Consulting Term”), Executive/Consultant shall provide advice and consultation as reasonably requested by the Company in connection with Executive/Consultant’s knowledge, expertise and areas of prior
responsibility for the Company (hereafter, the “Consulting Arrangement”), including without limitation, advising the EMEA board, assisting in any employment related litigation and consulting with the compensation committee of the board of
directors on various matters. Executive/Consultant shall be available to provide consulting services at such times and in such amount as requested by the Company, provided that the consulting services shall be performable by Executive/Consultant at
reasonable times, by telephone or email, and in a manner that will not conflict with Executive’s/Consultant’s personal or business obligations. The Company also hereby indemnifies Executive/Consultant, with respect to his provision of the
consulting services, to the fullest extent that would be permitted by law (including a payment of expenses in advance of final disposition of a proceeding) and in the same manner as would be required pursuant to Section 11 of the Employment
Agreement had Executive/Consultant remained employed by the Company during the Consulting Term. 
 (b) Consulting Fee. The
Company shall pay Executive/Consultant a Consulting Fee as follows: (i) from July 1, 2014, until December 31, 2014, the Company shall pay Executive/Consultant $50,000 per month, regardless of the number of hours spent by
Executive/Consultant on such consulting services, paid in monthly installments, and the Company shall reimburse Executive/Consultant for all expenses incurred by Consultant in connection with the performance of the consulting services; and
(ii) from the Employment Termination Date through December 31, 2014, the Company shall continue to provide Executive/Consultant with benefits equivalent to those to which he had received or would have been entitled under the Company’s
expatriate benefit package, including continued coverage of the Company’s attributed income (including but not limited to salary and consulting payments 

  
 2 

 
made by the Company to or on behalf of Executive/Consultant) under the Company’s tax equalization policy (personal income is excluded) and the benefit of any applicable foreign tax credits,
had Executive/Consultant remained employed provided that in lieu of any relocation expenses or benefits related to any relocation back to the United States provided for in such package, the Company shall pay to Executive/Consultant, on or before
December 31, 2014 (and regardless of whether Executive/Consultant relocates prior to such date), a lump sum payment of $600,000; such expatriate benefits (including, but not limited to, the lump sum payment provided in lieu of relocation
expenses or benefits) shall be grossed-up for income taxes consistent with prior practices to put the Executive in the same after-tax position as had such benefits and payments not constituted taxable income, and all of the Company’s attributed
income (including but not limited to salary and consulting payments made by the Company to or on behalf of Executive/Consultant) shall be subject to tax equalization consistent with prior practices, and Executive/Consultant shall also have the
benefit of any applicable foreign tax credits. The Company shall provide Executive/Consultant with tax preparation services for both the United States and the United Kingdom returns, as well as any applicable state and local tax returns, related to
the provision of expatriate services for the 2014 and 2015 tax years, and Executive/Consultant shall cooperate in good faith to reconcile all applicable payments and credits in accordance with past practices. The Company shall also continue to
provide medical, dental and vision insurance coverage to Executive/Consultant during the Consulting Term to the same extent that the Executive would be entitled if his employment continued through the Consulting Term (including dependent coverage),
at the Company’s expense, provided that such benefits shall be provided in such a manner that such benefits (and the costs and premiums thereof) are excluded from the Executive’s income for all income tax purposes; provided
further, however, that, if such benefits would otherwise be includible in the Executive’s income for federal income tax purposes, the Executive shall instead pay the full monthly premiums for continuation of such benefits under
the Consolidated Omnibus Budget Reconciliation Act of 1985, as amended (“COBRA”) (on an after-tax basis), and the Company shall pay to Executive an additional taxable amount equal to 200% of such monthly COBRA premiums paid by
Executive, each such amount to be paid to Executive no later than the 15th day of each calendar month beginning with the first calendar month following the calendar month that includes the
Employment Termination Date and continuing through the sixth calendar month following the calendar month that includes the Employment Termination Date. In the event of the death of the Executive, all payments payable hereunder, except for the
payment due under Section 3(b)(i), shall become payable to the Executive’s estate on the same schedule as otherwise due to Executive/Consultant. 

(c) Independent Contractor Status. The parties hereby acknowledge and agree that Executive/Consultant’s consulting services
for the Company under this Consulting Arrangement shall be provided strictly as an independent contractor. Nothing in this Consulting Agreement shall be construed to render him an employee, co-venturer, agent, or other representative of the Company
during the Consulting Term. Executive/Consultant understands that he must comply with all tax laws applicable to a self-employed individual, including the filing of any necessary tax returns and the payment of all income and self-employment taxes.
The Company shall not be required to withhold from the consulting fee any state or federal income taxes or to make payments for Social Security (“FICA”) tax, unemployment insurance, or any other payroll taxes. The Company shall not be
responsible for, and shall not obtain, 

  
 3 

 
worker’s compensation, disability benefits insurance, or unemployment security insurance coverage for Executive/Consultant. Executive/Consultant is not eligible for, nor entitled to, and
shall not participate in, any of the Company’s benefit plans (except as set forth in Sections 2(a), 2(c), 3(b) or 3(d)). Consistent with his duties and obligations under this Consulting Agreement, Executive/Consultant shall, at all times,
maintain sole and exclusive control over the manner and method by which he performs his consulting services. 
 (d) Stock
Options. For the avoidance of doubt, the parties acknowledge and agree that Executive/Consultant and the Company will continue to have a service relationship during the Consulting Term for purposes of the Company’s stock and option plans
and programs, and Executive/Consultant’s stock and option agreements, and that no termination or pending termination of the exercise period for any stock options is triggered by the Employment Termination Date in light of the continuing service
relationship. The parties intend that Executive/Consultant’s separation from service at the end of the Consulting Term will be considered a retirement under the Company’s stock and options plans and programs, and
Executive/Consultant’s stock and option agreements, and that Executive shall be treated for such purposes as if his employment had continued through the end of the Consulting Term for all purposes thereunder (including, without limitation,
vesting). The Company confirms that the “Committee” (as defined in the Company’s stock and options plans) has approved Executive’s retirement as of December 31, 2014 for all purposes. For the avoidance of doubt, the parties
agree that the tranche of options scheduled to vest in August 2014 shall continue to vest notwithstanding the termination of Executive’s employment on the Employment Termination Date. In the event of a conflict between the terms of this
Consulting Agreement, including this Section 3(d), and any of the Company’s stock and options plans and programs, and Executive/Consultant’s stock and option agreements, the terms of this Consulting Agreement shall control. 

4. ADEQUACY OF CONSIDERATION. Executive/Consultant acknowledges that the benefits available to him under this Consulting
Agreement are significant, are of greater value than the benefits to which he would be entitled to receive if he did not sign this Consulting Agreement, and constitute adequate consideration for the releases of claims, under Sections 7(a) and 8 of
this Consulting Agreement, and under the Supplemental General Release Agreement under Section 7(b) (to be executed on or within fifteen (15) days after the expiration of the Consulting Term, provided that the Company shall provide another
copy of the Supplemental General Release Agreement to Executive upon the expiration of the Consulting Term and request that he sign as provided herein). 

5. EMPLOYMENT AGREEMENT. Executive/Consultant acknowledges and agrees that this Consulting Agreement provides him with more
benefits than those to which he would be entitled under the Employment Agreement, and agrees that the Employment Agreement is hereby terminated, except that Executive/Consultant acknowledges and agrees that: (i) Sections 6.1, 6.2, 6.3, 7
through 9 and 11 through 19 of the Employment Agreement shall survive such termination, as modified by this Section 5; (ii) Section 6.1 of the Employment Agreement will continue to apply to information obtained by Executive/Consultant
during the Consulting Term; and (iii) the terms of Section 6.3 (Competitive Business Activities) of the Employment Agreement shall be modified to extend for the two (2) year period following the

  
 4 

 
Employment Termination Date, provided further that that Section 6.3(A)(iii) shall apply only with respect to persons who had been employed by the Company or its Affiliates during the 12
months preceding the Employment Termination Date. The Company acknowledges and agrees that (i) Sections 3.5 and 11 of the Employment Agreement shall survive termination of the Employment Agreement (and, with respect to Section 11, for the
avoidance of doubt, the Executive shall continue to be entitled to insurance under the Company’s directors’ and officers’ indemnification policies with respect to his prior services as an officer or director comparable to the coverage
that applies to other senior executives who serve at the level Executive/Consultant served, and (ii) without violating Section 6.3 of the Employment Agreement, (aa) the Executive/Consultant may serve as an officer, director, stockholder,
partner, associate, owner, employee, consultant of or to, or otherwise provide services to or on behalf of, an investment management company or one or more of its affiliates, which, among other things, will engage in the healthcare investment
business, and (bb) the Executive/Consultant may also serve as a director or advisor of or to, or otherwise provide services to, one or more portfolio companies invested in by such investment management company or its affiliates; provided such
portfolio company or its affiliates shall not materially compete with the Company, or one of its affiliates with whom Executive /Consultant had significant responsibility, in the contract research organization business (including real-world and late
phase research) or in the contract sales organization business. 
 6. COMPANY PROPERTY. Upon the expiration of the Consulting
Term as provided in Section 3(a), Executive/Consultant shall: (i) deliver to the Company all records, memoranda, data, documents and other property of any description which refer or relate in any way to trade secrets or confidential
information, including all copies thereof, which are in his possession, custody or control; (ii) deliver to the Company all Company property (including, but not limited to, keys, credit cards, computers, client files, contracts, proposals, work
in process, manuals, forms, computer stored work in process and other computer data, research materials, other items of business information concerning any Company customer or client or potential prospect to purchase some or all of the
Company’s assets, or Company business or business methods, including all copies thereof) which is in his possession, custody or control and (iii) prior to the Employment Termination Date, and if necessary during the Consulting Term, fully
cooperate with the Company in winding up his work and transferring that work to other individuals designated by the Company. 
 7.
RELEASE. 
 (a) CURRENT RELEASE. In consideration of the benefits conferred by this CONSULTING AGREEMENT,
EXECUTIVE/CONSULTANT(ON BEHALF OF HIMSELF, HIS FAMILY MEMBERS, HEIRS, ASSIGNS, EXECUTORS AND OTHER REPRESENTATIVES) RELEASES THE COMPANY AND ITS PAST, PRESENT AND FUTURE PARENTS, SUBSIDIARIES, AFFILIATES, AND ITS AND/OR THEIR PREDECESSORS,
SUCCESSORS, ASSIGNS, AND ITS AND/OR THEIR PAST, PRESENT AND FUTURE OFFICERS, DIRECTORS, EXECUTIVES, OWNERS, INVESTORS, SHAREHOLDERS, ADMINISTRATORS, BUSINESS UNITS, EXECUTIVE/CONSULTANT BENEFIT PLANS (TOGETHER WITH ALL PLAN ADMINISTRATORS, TRUSTEES,
FIDUCIARIES AND INSURERS) AND AGENTS (“RELEASEES”) FROM ALL CLAIMS 

  
 5 

 
AND WAIVES ALL RIGHTS KNOWN OR UNKNOWN, HE MAY HAVE OR CLAIM TO HAVE IN EACH CASE RELATING TO HIS EMPLOYMENT WITH THE COMPANY, OR HIS SEPARATION THEREFROM arising before the execution of
this Consulting Agreement by Executive, including but not limited to claims for: (i) discrimination, harassment or retaliation arising under any federal, state or local laws, or the equivalent applicable laws of a foreign country,
prohibiting age (including but not limited to claims under the Age Discrimination in Employment Act of 1967 (ADEA), as amended, and the Older Worker Benefit Protection Act of 1990 (OWBPA)), sex, national origin, race, religion, disability, veteran
status or other protected class discrimination, the Family and Medical Leave Act, as amended (FMLA), harassment or retaliation for protected activity; (ii) for compensation, commission payments, bonus payments and/or benefits including but not
limited to claims under the Fair Labor Standards Act of 1938 (FLSA), as amended, the Employee Retirement Income Security Act of 1974, as amended (ERISA), the Family and Medical Leave Act, as amended (FMLA), and similar federal, state, and local
laws, or the applicable laws of any foreign country; (iii) under federal, state or local law, or the applicable laws of any foreign country, of any nature whatsoever, including but not limited to constitutional, statutory; and common law; and
(iv) attorneys’ fees. Executive/Consultant specifically waives his right to bring or participate in any class or collective action against the Company. Provided, however, that this release does not apply to claims by Executive/Consultant:
(aa) for workers’ compensation benefits or unemployment benefits filed with the applicable state agencies; (bb) for vested pension or retirement benefits including under the Company’s 401(k) plan; (cc) to continuation coverage under COBRA,
or equivalent applicable law; (dd) to rights he may have to indemnification by the Company pursuant to the Company’s bylaws, articles of incorporation, insurance policies, this Consulting Agreement, Section 11 of the Employment Agreement
(which Section, for the avoidance of doubt, remains in full force and effect) or under applicable law; (ee) to rights arising out of his ownership of stock or options in the Company or its affiliates; (ff) to rights that cannot lawfully be released
by a private settlement agreement; (gg) to claims or rights that arise or accrue after Executive’s execution of this Consulting Agreement; or (hh) to enforce, or for a breach of, this Consulting Agreement (the “Reserved Claims”). For
the purpose of implementing a full and complete release and discharge, Executive/Consultant expressly acknowledges that this Consulting Agreement is intended to include in its effect, without limitation, all claims which he does not know or suspect
to exist in his favor at the time of execution hereof, and that this Consulting Agreement contemplated the extinguishment of any such claim or claims. 

(b) SUPPLEMENTAL GENERAL RELEASE. Executive/Consultant agrees that he will execute the Supplemental General Release Agreement,
attached hereto as Exhibit A, no earlier than the December 31, 2014, the date on which the Consulting Term expires under Section 3(a), and no later than fifteen (15) days after the expiration of such Term. 

8. COVENANT NOT TO SUE. In consideration of the benefits offered to Executive, Executive/Consultant will not sue Releasees on
any of the released claims or on any matters relating to his employment arising before the execution of this Consulting Agreement other than with respect to the Reserved Claims, including but not limited to claims under the ADEA, or join as a party
with others who may sue Releasees on any such claims; provided, however, this paragraph will not bar a challenge under the OWBPA to the enforceability of the 

  
 6 

 
waiver and release of ADEA claims set forth in this Consulting Agreement, the Reserved Claims, or where otherwise prohibited by law. If Executive/Consultant does not abide by this paragraph,
then(i) he will return all monies received under this Consulting Agreement and indemnify Releasees for all expenses incurred in defending the action, and (ii) Releasees will be relieved of their obligations hereunder. 

9. RIGHT TO REVIEW. The Company delivered this Consulting Agreement, containing the release language set forth in
Sections 7 and 8, to Executive/Consultant via email on May 8, 2014 (the “Notification Date”), and informed him that it desires that he have adequate time and opportunity to review and understand the consequences of entering into
it. The Company advises Executive/Consultant as follows: 
  

	 	•	 	Executive/Consultant should consult with his attorney prior to executing the Consulting Agreement; and 

  

	 	•	 	Executive/Consultant has 21 days from the Notification Date within which to consider it. 

 Executive/Consultant
must return an executed copy of the Consulting Agreement to the Company on or before the 22nd day following the Notification Date. Executive acknowledges and understands that he is not required to
use the entire 21-day review period and may execute and return this Consulting Agreement at any time before the 22nd day following the Notification Date. If, however, Executive does not execute
and return an executed copy of this Consulting Agreement on or before the 22nd day following the Notification Date, this Consulting Agreement shall become null and void. This executed Consulting
Agreement shall be returned to: James Erlinger, Executive Vice President and General Counsel, Quintiles Transnational Corp., 4820 Emperor Blvd., Durham, NC 27703. 

10. REVOCATION. Executive/Consultant may revoke the Consulting Agreement during the seven (7) day period immediately
following his execution of it. This Consulting Agreement will not become effective or enforceable until the revocation period has expired. To revoke this Supplemental General Release Agreement, a written notice of revocation must be delivered
to: James Erlinger, Executive Vice President and General Counsel, Quintiles Transnational Corp., 4820 Emperor Blvd., Durham, NC 27703. 

11. AGENCY CHARGES/INVESTIGATIONS. Nothing in this Consulting Agreement shall prohibit Executive/Consultant from filing a charge
or participating in an investigation or proceeding conducted by the U.S. Equal Employment Opportunity Commission or other governmental agency with jurisdiction concerning the terms, conditions and privileges of his employment; provided, however,
that by signing this Consulting Agreement, Executive/Consultant waives his right to, and shall not seek or accept, any monetary or other relief of any nature whatsoever in connection with any such charges, investigations or proceedings. 

12. NONDISPARAGEMENT. Both parties warrant that going forward neither will make disparaging, defaming or derogatory remarks
about the other or their respective services, business practices, directors, officers, managers, or executives, as applicable, to anyone. 

  
 7 

 13. REFERENCES. Executive/Consultant agrees that he will direct all written
inquiries from prospective employers to the Human Resources department. Executive/Consultant acknowledges and agrees that, consistent with its usual practices, the Company will provide only information about Executive/Consultant’s positions,
dates of employment and salary. 
 14. DISCLAIMER OF LIABILITY. Nothing in this Consulting Agreement is to be construed as
either an admission of liability or admission of wrongdoing on the part of either party, each of which denies any liabilities or wrongdoing on its part. 

15. GOVERNING LAW. This Consulting Agreement shall be governed by the laws of North Carolina, without regard to its conflict of
laws provisions and the applicable provisions of federal law, including, but not limited to, the ADEA and OWBPA. 
 16. ENTIRE
AGREEMENT. Except as expressly provided herein, this Consulting Agreement: (i) supersedes and cancels all other understandings and agreements, oral or written, with respect to Executive’s employment with the Company;
(ii) supersedes all other understandings and agreements, oral or written, between the parties with respect to the subject matter of this Consulting Agreement; and (iii) constitutes the sole agreement between the parties with respect to
this subject matter. Each party acknowledges that: (i) no representations, inducements, promises or agreements, oral or written, have been made by any party or by anyone acting on behalf of any party, which are not embodied in this Consulting
Agreement; and (ii) no agreement, statement or promise not contained in this Consulting Agreement shall be valid. No change or modification of this Consulting Agreement shall be valid or binding upon the parties unless such change or
modification is in writing and is signed by the parties. 
 17. SEVERABILITY; SEPARATE AND INDEPENDENT COVENANTS. If
any portion, provision, or part of this Consulting Agreement is held, determined, or adjudicated by any court of competent jurisdiction to be invalid, unenforceable, void, or voidable for any reason whatsoever, each such portion, provision, or part
shall be severed from the remaining portions, provisions, or parts of this Consulting Agreement, and such determination or adjudication shall not affect the validity or enforceability of such remaining portions, provisions, or parts. The Company
acknowledges and agrees that each of Executive’s covenants in this Agreement or the Employment Agreement shall be construed for all purposes to be separate and independent from any other covenant, whether in this Consulting Agreement or
otherwise, and the existence of any claim by the Company or any of its affiliates against Executive under this Consulting Agreement, the Employment Agreement or otherwise, will not excuse the Company’s breach of any covenant contained in this
Consulting Agreement. 
 18. SECTION 409A OF THE INTERNAL REVENUE CODE. 

(a) Parties’ Intent. The parties intend that no payments or benefits hereunder shall constitute non-qualified deferred
compensation within the meaning of Section 409A of the Internal Revenue Code of 1986, as amended (the “Code”), and the regulations thereunder (collectively, “Section 409A”) and all provisions of this Consulting Agreement
shall be construed in a manner consistent with such intention. If any provision of this Consulting Agreement (or of any award of compensation, including equity compensation or benefits) would 

  
 8 

 
cause Executive/Consultant to incur any additional tax or interest under Section 409A, the Company shall, upon the specific request of Executive, use its reasonable business efforts to in
good faith reform such provision to be exempt from, or comply with, Code Section 409A; provided, that to the maximum extent practicable, the original intent and economic benefit to Executive/Consultant and the Company of the applicable
provision shall be maintained, and the Company shall have no obligation to make any changes that could create any material additional economic cost or loss of material benefit to the Company. The Company shall timely use its reasonable business
efforts to amend any plan or program in which Executive/Consultant participates to bring it under an exemption from, or in compliance with, Section 409A. Notwithstanding the foregoing, the Company shall have no liability with regard to any
failure to comply with Section 409A so long as it has acted in good faith with regard to compliance therewith. 
 (b)
Separation from Service. A termination of employment or separation from service shall not be deemed to have occurred for purposes of any provision of this Consulting Agreement providing for the payment of any amounts or benefits that
constitute nonqualified deferred compensation within the meaning of Section 409A upon or following a termination of employment or separation from service unless such termination also constitutes a “Separation from Service” within the
meaning of Section 409A and, for purposes of any such provision of this Consulting Agreement, references to a “termination,” “termination of employment,” “separation from service” or like terms shall mean
Separation from Service. 
 (c) Separate Payments. Each installment payment required under this Consulting Agreement
shall be considered a separate payment for purposes of Section 409A. 
 (d) Delayed Distribution to Specified Employees.
If the Company determines in accordance with Sections 409A and 416(i) of the Code and the regulations promulgated thereunder, in the Company’s sole discretion, that Executive/Consultant is a Specified Employee of the Company on the date he
experiences a separation from service with the Company and that a delay in benefits provided under this Consulting Agreement is necessary to comply with Code Section 409A(A)(2)(B)(i), then any post separation payments and any continuation of
benefits or reimbursement of benefit costs provided by this Consulting Agreement, and not otherwise exempt from Section 409A, shall be delayed for a period of six (6) months following the date of Executive/consultant’s separation from
service (the “409A Delay Period”). In such event, any post separation payments and the cost of any continuation of benefits provided under this Consulting Agreement that would otherwise be due and payable to Executive/Consultant during the
409A Delay Period shall be paid to Executive/Consultant in a lump sum cash amount in the month following the end of the 409A Delay Period. For purposes of this Consulting Agreement, “Specified” shall mean an employee who, on an
Identification Date (“Identification Date” shall mean each December 31) is a key employee as defined in Section 416(i) of the Code without regard to paragraph (5) thereof. If Executive/Consultant is identified as a Specified
Employee on an Identification Date, then Executive/Consultant shall be considered a Specified Employee for purposes of this Consulting Agreement during the period beginning on the first April 1 following the Identification Date and ending on
the following March 31. 

  
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 19. COUNTERPARTS. This Consulting Agreement may be executed in any number of
counterparts, each of which shall be deemed an original, and all of which taken together shall constitute one and the same instrument. Any party hereto may execute this Consulting Agreement by signing any such counterpart. 

20. WAIVER OF BREACH. A waiver of any breach of this Consulting Agreement shall not constitute a waiver of any other provision
of this Consulting Agreement or any subsequent breach of this Consulting Agreement. 
 (Signature Page Follows) 

  
 10 

 (Signature page to Consulting Agreement) 

IN WITNESS WHEREOF, the parties have entered into this Consulting Agreement as of the day and year written below. 

 

			
	QUINTILES TRANSNATIONAL CORP.
		
	By:	 	 /s/ Garrett Walker

		
	Name:	 	Garrett Walker
		
	Title:	 	Chief HR Officer
		
	Date:	 	May 12, 2014
	
	MICHAEL I. MORTIMER
		
	By:	 	 /s/ Michael I. Mortimer

		
	Date:	 	May 12, 2014

  
 11 

 EXHIBIT A TO CONSULTING AND RELEASE AGREEMENT 

SUPPLEMENTAL GENERAL RELEASE AGREEMENT 

This Supplemental General Release Agreement (the “Supplemental General Release Agreement”) is made and entered into between
Quintiles Transnational Corp. (the “Company”) and Michael Mortimer (the “Executive” or “Consultant” or “Executive/Consultant”). Throughout the remainder of the Supplemental General Release Agreement, the
Company and Executive or Consultant may be collectively referred to as “the parties.” 
 The parties executed a Consulting and
Release Agreement (the “Consulting Agreement”) on May 12, 2014, under which Executive resigned from his employment as the Executive Vice President, Human Resources and Corporate Administration of the Company, and provided consulting
services thereafter until the Consulting Term expired, pursuant to Section 3(a) of the Consulting Agreement, and pursuant to which Executive shall be deemed for all purposes to have retired from the Company as of December 31, 2014.
Capitalized terms not defined in this Supplemental General Release Agreement shall have the definitions given to them in the Consulting Agreement. 

As a condition of the Company’s agreement to the terms of the Consulting Agreement, Executive/Consultant agreed to, among other things,
execute this Supplemental General Release Agreement on or within five (5) days after the expiration of the Consulting Term. 

Executive/Consultant represents that he has carefully read this entire Supplemental General Release Agreement, understands its consequences,
and voluntarily enters into it. 
 In consideration of the above and the mutual promises set forth in the Consulting Agreement,
Executive/Consultant and the Company agree as follows: 
 1. SUPPLEMENTAL RELEASE. In consideration of the benefits conferred by the
Consulting Agreement, and pursuant to his obligation under Section 6(b) of the Consulting Agreement, EXECUTIVE/CONSULTANT (ON BEHALF OF HIMSELF, HIS FAMILY MEMBERS, HEIRS, ASSIGNS, EXECUTORS AND OTHER REPRESENTATIVES) RELEASES THE COMPANY AND
ITS PAST, PRESENT AND FUTURE PARENTS, SUBSIDIARIES, AFFILIATES, AND/OR THEIR PREDECESSORS, SUCCESSORS, ASSIGNS, AND THEIR PAST, PRESENT AND FUTURE OFFICERS, DIRECTORS, EXECUTIVES, OWNERS, INVESTORS, SHAREHOLDERS, ADMINISTRATORS, BUSINESS UNITS,
EXECUTIVE/CONSULTANTBENEFIT PLANS (TOGETHER WITH ALL PLAN ADMINISTRATORS, TRUSTEES, FIDUCIARIES AND INSURERS) AND AGENTS (“RELEASEES”) FROM ALL CLAIMS AND WAIVES ALL RIGHTS KNOWN OR UNKNOWN, HE MAY HAVE OR CLAIM TO HAVE IN
EACH CASE RELATING TO HIS EMPLOYMENT WITH THE COMPANY, OR HIS RETENTION AS A CONSULTANT, OR HIS SEPARATION THEREFROM arising before the execution of the Supplemental General Release Agreement, including but not limited to claims for:
(i) discrimination, harassment or retaliation arising under any federal, state or local laws, or the equivalent applicable laws of a foreign country, prohibiting age (including but not limited to claims under the Age

  
 1 

 
Discrimination in Employment Act of 1967 (ADEA), as amended, and the Older Worker Benefit Protection Act of 1990 (OWBPA)), sex, national origin, race, religion, disability, veteran status or
other protected class discrimination, the Family and Medical Leave Act, as amended (FMLA), harassment or retaliation for protected activity; (ii) for compensation, commission payments, bonus payments and/or benefits including but not limited to
claims under the Fair Labor Standards Act of 1938 (FLSA), as amended, the Employee Retirement Income Security Act of 1974, as amended (ERISA), the Family and Medical Leave Act, as amended (FMLA), and similar federal, state, and local laws, or the
applicable laws of any foreign country; (iii) under federal, state or local law, or the applicable laws of any foreign country, of any nature whatsoever, including but not limited to constitutional, statutory; and common law; and
(iv) attorneys’ fees. Provided, however, that this release does not apply to claims by Executive/Consultant (aa) for workers’ compensation benefits or unemployment benefits filed with the applicable state agencies; (bb) for vested
pension or retirement benefits including under the Company’s 401(k) plan; (cc) to continuation coverage under COBRA, or equivalent applicable law; (dd) to rights he may have to indemnification by the Company pursuant to the Company’s
bylaws, articles of incorporation, insurance policies, the Consulting Agreement, Section 11 of the Employment Agreement (which Section, for the avoidance of doubt, remains in full force and effect) or under applicable law; (ee) to rights
arising out of his ownership of stock or options in the Company or its affiliates; (ff) to rights that cannot lawfully be released by a private settlement agreement; (gg) to claims or rights that arise or accrue after Executive’s execution of
this Supplemental General Release Agreement; or (hh) to enforce, or for a breach of, the Consulting Agreement (the “Reserved Claims”). For the purpose of implementing a full and complete release and discharge, Executive/Consultant
expressly acknowledges that this Supplemental General Release Agreement is intended to include in its effect, without limitation, all claims which he does not know or suspect to exist in his favor at the time of execution hereof, and that this
Supplemental General Release Agreement contemplated the extinguishment of any such claim or claims. 
 2. COVENANT NOT TO SUE. In
consideration of the benefits conferred by the Consulting Agreement, Executive/Consultant will not sue Releasees any matters relating to his employment arising before the execution of the Consulting Agreement (other than with respect to the Reserved
Claims) or before execution of this Supplemental General Release Agreement on any of the released claims, including but not limited to claims under the ADEA, or join as a party with others who may sue Releasees on any such claims; provided, however,
this paragraph will not bar a challenge under the OWBPA to the enforceability of the waiver and release of ADEA claims set forth in this Supplemental General Release Agreement, the Reserved Claims, or where otherwise prohibited by If
Executive/Consultant does not abide by this paragraph, then (i) he will return all monies received under this Consulting Agreement and indemnify Releasees for all expenses incurred in defending the action, and (ii) Releasees will be
relieved of their obligations hereunder. 
 3. RIGHT TO REVIEW. The Company delivered to Executive/Consultant via email this
Supplemental General Release Agreement, containing the release language set forth in Sections 1 and 2, or around May 8, 2014 (the “Notification Date”) and informs him hereby that it desires that he have adequate time and
opportunity to review and understand the consequences of entering into it. Accordingly, the Company advises Executive/Consultant as follows: 
  

	 	•	 	Executive/Consultant should consult with his attorney prior to executing the Supplemental General Release Agreement; and 

  
 2 

	 	•	 	Executive/Consultant has more than 21 days from the Notification Date within which to consider whether to execute the Supplemental General Release Agreement. 

Executive/Consultant must return an executed copy of the Supplemental General Release Agreement to the Company within 5 days following the expiration of the
Consulting Term under Section 3(a) of the Consulting Agreement, but not before such expiration. The executed Supplemental General Release Agreement should be returned to: James Erlinger, Executive Vice President and General Counsel,
Quintiles Transnational Corp., 4820 Emperor Blvd., Durham, NC 27703. 
 4. REVOCATION. Executive/Consultant may revoke the
Supplemental General Release Agreement during the seven (7) day period immediately following his execution of it. This Consulting Agreement will not become effective or enforceable until the revocation period has expired. To revoke this
Supplemental General Release Agreement, a written notice of revocation must be delivered to: James Erlinger, Executive Vice President and General Counsel, Quintiles Transnational Corp., 4820 Emperor Blvd., Durham, NC 27703.

 5. AGENCY CHARGES/INVESTIGATIONS. Nothing in this Supplemental General Release Agreement or in the Consulting Agreement
shall prohibit Executive/Consultant from filing a charge or participating in an investigation or proceeding conducted by the U.S. Equal Employment Opportunity Commission or other governmental agency with jurisdiction concerning the terms, conditions
and privileges of his employment; provided, however, that by signing this Supplemental General Release Agreement and the Consulting Agreement, Executive/Consultant waives his right to, and shall not seek or accept, any monetary or other relief of
any nature whatsoever in connection with any such charges, investigations or proceedings. 
 6. DISCLAIMER OF
LIABILITY. Nothing in this Supplemental General Release Agreement or in the Consulting Agreement is to be construed as either an admission of liability or admission of wrongdoing on the part of either party, each of which denies any liabilities
or wrongdoing on its part. 
 7. GOVERNING LAW. This Supplemental General Release Agreement shall be governed by the
laws of North Carolina, without regard to its conflict of laws provisions and the applicable provisions of federal law, including, but not limited to, the ADEA and OWBPA.  

8. ENTIRE AGREEMENT. Except for the Consulting Agreement and as expressly provided herein and therein, this Supplemental General
Release Agreement: (i) supersedes and cancels all other understandings and agreements, oral or written, with respect to Executive’s employment with the Company; (ii) supersedes all other understandings and agreements, oral or written,
between the parties with respect to the subject matter of the Consulting Agreement; and (iii) constitutes the sole agreement between the parties with respect to this subject matter. Each 

  
 3 

 
party acknowledges that: (i) no representations, inducements, promises or agreements, oral or written, have been made by any party or by anyone acting on behalf of any party, which are not
embodied in this Supplemental General Release Agreement or in the Consulting Agreement; and (ii) no agreement, statement or promise not contained in this Consulting Agreement shall be valid. No change or modification of this Supplemental
General Release Agreement or in the Consulting Agreement shall be valid or binding upon the parties unless such change or modification is in writing and is signed by the parties. 

9. SEVERABILITY; SEPARATE AND INDEPENDENT COVENANTS. If any portion, provision, or part of this Supplemental General Release Agreement
is held, determined, or adjudicated by any court of competent jurisdiction to be invalid, unenforceable, void, or voidable for any reason whatsoever, each such portion, provision, or part shall be severed from the remaining portions, provisions, or
parts of this Supplemental General Release Agreement, and such determination or adjudication shall not affect the validity or enforceability of such remaining portions, provisions, or parts. The Company acknowledges and agrees that each of
Executive’s covenants in this Agreement or the Employment Agreement shall be construed for all purposes to be separate and independent from any other covenant, whether in this Consulting Agreement or otherwise, and the existence of any claim by
the Company or any of its affiliates against Executive under this Consulting Agreement, the Employment Agreement or otherwise, will not excuse the Company’s breach of any covenant contained in this Consulting Agreement. 

10. COUNTERPARTS. This Supplemental General Release Agreement may be executed in any number of counterparts, each of which shall be
deemed an original, and all of which taken together shall constitute one and the same instrument. Any party hereto may execute this Supplemental General Release Agreement by signing any such counterpart. 

11. WAIVER OF BREACH. A waiver of any breach of this Supplemental General Release Agreement or of the Consulting Agreement shall not
constitute a waiver of any other provision of this Supplemental General Release Agreement or of the Consulting Agreement or any subsequent breach of this Supplemental General Release Agreement or of the Consulting Agreement. 

[The remainder of this page intentionally left blank] 

  
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 IN WITNESS WHEREOF, the parties have entered into this Supplemental General Release Agreement as
of the day and year written below. 
  

			
	QUINTILES TRANSNATIONAL CORP.
		
	By:	 	  

		
	Name:	 	
		
	Title:	 	
		
	Date:	 	
	
	MICHAEL I. MORTIMER
		
	By:	 	  

		
	Date:	 	

  
 5

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