Document:

Vicuron Pharmaceuticals Inc. 2003 New-Hire Stock Option Plan

 Exhibit 10.12 
  
 VICURON PHARMACEUTICALS INC. 
 2003 NEW-HIRE STOCK OPTION PLAN 
  

	1.    	PURPOSES. 

  
 (a) The purpose of the Plan is to provide a means by which selected Employees of the Company and its Affiliates may be given an opportunity to benefit
from increases in the value of the stock of the Company through the granting of Options, as defined below. 
  
 (b) The Company, by means of the Plan, seeks to secure and retain the services of new Employees and to provide incentives for such persons to exert
maximum efforts for the success of the Company and its Affiliates. 
  

	2.    	DEFINITIONS. 

  
 (a) “Affiliate” means any parent corporation or subsidiary corporation, whether now or hereafter existing, as those terms are
defined in Sections 424(e) and (f) respectively, of the Code. 
  
 (b) “Board” means the Board of Directors of the Company. 
  
 (c) “Cause” means (unless otherwise expressly provided in the applicable Option Agreement, or another applicable contract with the Option holder that defines such term for purposes of
determining the effect that a “for cause” termination has on the holder’s Options granted under the Plan) that the Company, acting in good faith based upon the information then known to the Company, determines that the Option holder
has: (1) repeatedly failed to perform in a material respect his obligations under any employment agreement with the Company without proper reason and has not cured such failure in a reasonable time after receiving notice from the Company, (2)
willfully engaged in illegal conduct or gross misconduct that is materially injurious to the Company, or (3) breached the provisions of any confidentiality agreement or confidentiality provisions of any employment agreement with the Company.

  
 For purposes of this provision, no act or failure to act, on
the part of the Option holder, shall be considered “willful” unless it is done, or omitted to be done, by the Option holder in bad faith or without reasonable belief that the Option holder’s action or omission was in the best
interests of the Company. Any act, or failure to act, based upon authority given pursuant to a resolution duly adopted by the Board or upon the instructions of the chief executive officer or a senior officer of the Company or based upon the advice
of counsel for the Company shall be conclusively presumed to be done, or omitted to be done, by the Option holder in good faith and in the best interests of the Company. No termination of the Option holder for Cause will be effective unless adopted
pursuant to a resolution duly adopted by the affirmative vote of not less than a majority of the entire membership of the Board at a meeting of the Board called and held for such purpose, and communicated to the Option holder by written notice that
explains the basis on which Cause has been found. 

 (d) “Change in Control” means any of the following: 
  

	 	(i)	Approval by the stockholders of the Company of the dissolution or liquidation of the Company; 

  
 (ii) Approval by the stockholders of the Company of an agreement to merge or consolidate, or otherwise
reorganize, with or into one or more entities that are not subsidiaries or other affiliates, as a result of which less than 50% of the outstanding voting securities of the surviving or resulting entity immediately after the reorganization are, or
will be, owned, directly or indirectly, by stockholders of the Company immediately before such reorganization (assuming for purposes of such determination that there is no change in the record ownership of the Company’s securities from the
record date for such approval until such reorganization and that such record owners hold no securities of the other parties to such reorganization, but including in such determination any securities of the other parties to such reorganization held
by affiliates of the Company); 
  
 (iii) Approval
by the stockholders of the Company of the sale of substantially all of the Company’s business and/or assets to a person or entity which is not a subsidiary or other affiliate; 
  
 (iv) Any “person” (as such term is used in Sections 13(d) and 14(d) of the Securities Exchange Act
of 1934 (the “Exchange Act”) but excluding any person described in and satisfying the conditions of Rule 13d-1(b)(1) thereunder), becomes the “beneficial owner” (as defined in Rule 13d-3 under the Exchange Act), directly or
indirectly, of securities of the Company representing more than 40% of the combined voting power of the Company’s then outstanding securities entitled to then vote generally in the election of directors of the Company; or 
  
 (v) During any period not longer than two consecutive years,
individuals who at the beginning of such period constituted the Board of Directors of the Company cease to constitute at least a majority thereof, unless the election, or the nomination for election by the Corporation’s stockholders, of each
new Board member was approved by a vote of at least three-fourths of the Board members then still in office who were Board members at the beginning of such period (including for these purposes, new members whose election or nomination was so
approved. 
  
 (e) “Code” means the
Internal Revenue Code of 1986, as amended. 
  
 (f)
“Committee” means a Committee appointed by the Board in accordance with subsection 3(a) of the Plan. 
  
 (g) “Company” means Vicuron Pharmaceuticals Inc., a Delaware corporation. 
  
 (h) “Consultant” means any person, including an
advisor, engaged by the Company or an Affiliate to render consulting services and who is compensated for such services, provided that the term “Consultant” shall not include Directors who are paid only a director’s fee by the Company
or who are not compensated by the Company for their services as Directors. 
  

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 (i) “Continuous Status as an Employee, Director or Consultant” means that the
service of an individual to the Company, whether as an Employee, Director or Consultant, is not interrupted or terminated. The Board or the chief executive officer of the Company may determine, in that party’s sole discretion, whether
Continuous Status as an Employee, Director or Consultant shall be considered interrupted in the case of: (i) any leave of absence approved by the Board or the chief executive officer of the Company, including sick leave, military leave, or any other
personal leave; or (ii) transfers between the Company, Affiliates or their successors. 
  
 (j) “Director” means a member of the Board. 
  
 (k) “Employee” means any person, including officers and Directors, employed by the Company or any Affiliate of the Company.
Neither service as a Director nor payment of a director’s fee by the Company shall be sufficient to constitute “employment” by the Company. 
  
 (l) “Exchange Act” means the Securities Exchange Act of 1934, as amended. 
  
 (m) “Fair Market Value” means the last reported sales
price on the relevant date of a share of the Company’s common stock as listed in the Wall Street Journal, or if there are no reported sales on such date, then the last reported sales price on the next preceding day on which such a sale is
transacted. 
  
 (n) “Nonstatutory Stock
Option” means an Option not intended to qualify as an Incentive Stock Option under Section 422 of the Code. 
  
 (o) “Option” means a stock option granted pursuant to the Plan. Each Option granted pursuant to the Plan shall be a Nonstatutory
Stock Option. 
  
 (p) “Optionee” means a
person to whom an Option is granted pursuant to the Plan or, if applicable, such other person who holds an outstanding Option. 
  
 (q) “Plan” means this 2003 New-Hire Stock Option Plan. 
  
 (r) “Rule 16b-3” means Rule 16b-3 of the Exchange Act or any successor to Rule 16b-3, as in effect
with respect to the Company at the time discretion is being exercised regarding the Plan. 
  
 (s) “Securities Act” means the Securities Act of 1933, as amended. 
  
 (t) “Option Agreement” means a written agreement between the Company and the recipient of an Option evidencing the terms and
conditions of the particular Option grant. Each Option Agreement shall be subject to the terms and conditions of the Plan. 
  

	3.	    ADMINISTRATION. 

  
 (a) The Board shall appoint a committee (the “Committee”) of the Board to administer this Plan, which committee shall be composed of not fewer
than two (2) Board members each of whom shall be independent within the meaning of applicable listing requirements. 
  

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 (b) The Committee shall have the power, subject to, and within the limitations of, the express provisions
of the Plan: 
  
 (1) To determine from time to time which of the
persons eligible under the Plan shall be granted Options; when and how each Option will be granted; when and how each Option shall be granted; and the provisions of each Option granted (which need not be identical), including the time or times when
a person shall be permitted to receive stock pursuant to an Option and the number of shares with respect to which an Option shall be granted to each such person. 
  
 (2) To construe and interpret the Plan and Options granted under it, and to establish, amend and revoke rules and
regulations for its administration. The Committee, in the exercise of this power, may correct any defect, omission or inconsistency in the Plan or in any Option Agreement, in a manner and to the extent it shall deem necessary or expedient to make
the Plan fully effective. 
  
 (3) To amend the Plan or an Option
as provided in Section 11; provided, however, that the Committee shall not have the power to reprice any Option once granted, except for adjustments resulting from a stock split, reverse stock split, or similar change to the outstanding capital
stock, as provided in Section 10. 
  
 (4) Generally, to exercise
such powers and to perform such acts as the Committee deems necessary or expedient to promote the best interests of the Company that are not in conflict with the provisions of the Plan. 
  

	4.	    SHARES SUBJECT TO THE PLAN. 

  
 (a) Subject to the provisions of Section 10 relating to adjustments upon
changes in stock, the stock that may be issued pursuant to Options shall not exceed in the aggregate 750,000 shares of the Company’s common stock. If any Option shall for any reason expire or otherwise terminate, in whole or in part, without
having been exercised in full, the stock not acquired under such Option shall revert to and again become available for issuance under the Plan. 
  
 (b) The stock subject to the Plan may be unissued shares or reacquired shares, bought on the market or otherwise. 
  

	5.	    ELIGIBILITY. 

  
 Options may be granted only to Employees. Only the Committee may approve an Option grant under this Plan. Each Option granted under this
Plan shall be made only as an inducement material to the Employee’s entering into employment with the Company or an Affiliate of the Company and only if the Employee was not previously an employee or director of the Company or any Affiliate of
the Company (or following a bona fide period of non-employment). 
  

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 6.     OPTION PROVISIONS. 
  
 Each Option shall be in such form and shall contain such terms and
conditions as the Committee shall deem appropriate. The provisions of separate Options need not be identical, but each Option shall include (through incorporation of provisions hereof by reference in the Option or otherwise) the substance of each of
the following provisions: 
  
 (a) Term. No Option shall be
exercisable after the expiration of ten (10) years from the date it was granted. 
  
 (b) Price. The exercise price of each Option shall be not less than one hundred percent (100%) of the fair market value of the stock subject to the Option on the date the Option is granted. For this purpose,
“fair market value” shall mean Fair Market Value unless, as to any particular Option granted to a non-U.S. Employee, Director or Consultant, the Board or Committee determines that another definition of fair market value is necessary or
advisable in order to qualify the option for favorable tax treatment under applicable foreign law (an alternative definition of fair market value for this purpose could, without limitation, be based on the closing price of the stock underlying the
Option on a different day than the day relevant for purposes of determining Fair Market Value, or be based on an average of trading or closing prices of the stock underlying the Option for a particular day or other period of time). 
  
 (c) Consideration. The purchase price of stock acquired pursuant to an
Option shall be paid either in cash or by check at the time the Option is exercised. 
  
 (d) Transferability. An Option shall only be transferable by the Optionee upon such terms and conditions as are set forth in the Option Agreement for such Option, as the Board or the Committee shall determine
in its discretion or pursuant to a domestic relations order. The person to whom the Option is granted may, by delivering written notice to the Company, in a form satisfactory to the Company, designate a third party who, in the event of the death of
the Optionee, shall thereafter be entitled to exercise the Option. 
  
 (e) Vesting. The total number of shares of stock subject to an Option may, but need not, be allotted in periodic installments (which may, but need not, be equal). The Option Agreement may provide that from time to time during each of
such installment periods, the Option may become exercisable (“vest”) with respect to some or all of the shares allotted to that period, and may be exercised with respect to some or all of the shares allotted to such period and/or any prior
period as to which the Option became vested but was not fully exercised. The Option may be subject to such other terms and conditions on the time or times when it may be exercised (which may be based on performance or other criteria) as the
Committee may deem appropriate. The provisions of this subsection 6(e) are subject to any Option provisions governing the minimum number of shares as to which an Option may be exercised. 
  
 (f) Termination of Employment or Relationship as a Director or Consultant. In the event an Optionee’s Continuous
Status as an Employee, Director or Consultant terminates (other than upon the Optionee’s death or disability), the Optionee may exercise his or her Option (to the extent that the Optionee was entitled to exercise it as of the date of
termination) but only within such period of time ending on the earlier of (i) the date three (3) months following the 

  

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termination of the Optionee’s Continuous Status as an Employee, Director or Consultant (or such longer or shorter period specified in the Option
Agreement), or (ii) the expiration of the term of the Option as set forth in the Option Agreement. If, at the date of termination, the Optionee is not entitled to exercise his or her entire Option, the shares covered by the unexercisable portion of
the Option shall revert to and again become available for issuance under the Plan. If, after termination, the Optionee does not exercise his or her Option within the time specified in the Option Agreement, the Option shall terminate, and the shares
covered by such Option shall revert to and again become available for issuance under the Plan. 
  
 An Optionee’s Option Agreement may also provide that if the exercise of the Option following the termination of the Optionee’s Continuous Status as an Employee, Director, or Consultant (other than upon the
Optionee’s death or disability) would result in liability under Section 16(b) of the Exchange Act, then the Option shall terminate on the earlier of (i) the expiration of the term of the Option set forth in the Option Agreement, or (ii) the
tenth (10th) day after the last date on which such exercise would result in such liability under Section 16(b) of the Exchange Act. Finally, an Optionee’s Option Agreement may also provide that if the exercise of the Option following the
termination of the Optionee’s Continuous Status as an Employee, Director or Consultant (other than upon the Optionee’s death or disability) would be prohibited at any time solely because the issuance of shares would violate the
registration requirements under the Securities Act, then the Option shall terminate on the earlier of (i) the expiration of the term of the Option set forth in the first paragraph of this subsection 6(f), or (ii) the expiration of a period of three
(3) months after the termination of the Optionee’s Continuous Status as an Employee, Director or Consultant during which the exercise of the Option would not be in violation of such registration requirements. 
  
 (g) Disability of Optionee. In the event an Optionee’s Continuous
Status as an Employee, Director or Consultant terminates as a result of the Optionee’s disability, the Optionee may exercise his or her Option (to the extent that the Optionee was entitled to exercise it as of the date of termination), but only
within such period of time ending on the earlier of (i) the date twelve (12) months following such termination (or such longer or shorter period specified in the Option Agreement), or (ii) the expiration of the term of the Option as set forth in the
Option Agreement. If, at the date of termination, the Optionee is not entitled to exercise his or her entire Option, the shares covered by the unexercisable portion of the Option shall revert to and again become available for issuance under the
Plan. If, after termination, the Optionee does not exercise his or her Option within the time specified herein, the Option shall terminate, and the shares covered by such Option shall revert to and again become available for issuance under the Plan.

  
 (h) Death of Optionee. In the event of the death of an
Optionee during, or within a period specified in the Option Agreement after the termination of, the Optionee’s Continuous Status as an Employee, Director or Consultant, the Option may be exercised (to the extent the Optionee was entitled to
exercise the Option as of the date of death) by the Optionee’s estate, by a person who acquired the right to exercise the Option by bequest or inheritance or by a person designated to exercise the option upon the Optionee’s death pursuant
to subsection 6(d), but only within the period ending on the earlier of (i) the date eighteen (18) months following the date of death (or such longer or shorter period specified in the Option Agreement), or (ii) the expiration of the term of such
Option as set forth in the Option Agreement. If, at the time of death, the 

  

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Optionee was not entitled to exercise his or her entire Option, the shares covered by the unexercisable portion of the Option shall revert to and again
become available for issuance under the Plan. If, after death, the Option is not exercised within the time specified herein, the Option shall terminate, and the shares covered by such Option shall revert to and again become available for issuance
under the Plan. 
  
 7.     COVENANTS
OF THE COMPANY. 
  
 (a) During the terms of the Options, the Company shall keep available at all times the number of shares of stock required to satisfy such Options. 
  
 (b) The Company shall seek to obtain from each regulatory commission or agency having jurisdiction over the Plan such authority as may be required to
issue and sell shares of stock upon exercise of the Option; provided, however, that this undertaking shall not require the Company to register under the Securities Act either the Plan, any Option or any stock issued or issuable pursuant to any such
Option. If, after reasonable efforts, the Company is unable to obtain from any such regulatory commission or agency the authority which counsel for the Company deems necessary for the lawful issuance and sale of stock under the Plan, the Company
shall be relieved from any liability for failure to issue and sell stock upon exercise of such Options unless and until such authority is obtained. 
  
 8.     USE OF PROCEEDS FROM STOCK. 
  
 Proceeds from the sale of stock pursuant to Options shall constitute general
funds of the Company. 
  
 9.     MISCELLANEOUS. 
  
 (a) The Committee shall have the power to accelerate the time at which an Option may first be exercised or the time during which an Option or any part thereof will vest notwithstanding the provisions in the Option
stating the time at which it may first be exercised or the time during which it will vest. 
  
 (b) Neither an Employee nor any person to whom an Option is transferred (to the extent such a transfer is otherwise permitted) shall be deemed to be the holder of, or to have any of the rights of a holder with respect
to, any shares subject to such Option unless and until such person has satisfied all requirements for exercise of the Option pursuant to its terms. 
  
 (c) Nothing in the Plan or any instrument executed or Option granted pursuant thereto shall confer upon any Employee or other holder of Options any right
to continue in the employ of the Company or any Affiliate (or to continue acting as a Director or Consultant) or shall affect the right of the Company or any Affiliate to terminate the employment of any Employee with or without cause, the right of
the Company’s Board of Directors and/or the Company’s stockholders to remove any Director as provided in the Company’s By-Laws and the provisions of the Delaware General Corporation Law, or the right to terminate the relationship of
any Consultant subject to the terms of such Consultant’s agreement with the Company or Affiliate. 
  

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 (d) To the extent provided by the terms of an Option Agreement, the person to whom an Option is granted
may satisfy any federal, state or local tax withholding obligation relating to the exercise or acquisition of stock under an Option by any of the following means or by a combination of such means: (1) tendering a cash payment; (2) authorizing the
Company to withhold shares from the shares of the common stock otherwise issuable to the participant as, a result of the exercise or acquisition of stock under the Option; or (3) delivering to the Company owned and unencumbered shares of the common
stock of the Company. 
  
 10.       ADJUSTMENTS UPON CHANGES IN STOCK. 
  
 (a) If any change is made in the stock subject to the Plan, or subject to any Option (through merger, consolidation,
reorganization, recapitalization, reincorporation, stock dividend, dividend in property other than cash, stock split, liquidating dividend, combination of shares, exchange of shares, change in corporate structure or other transaction not involving
the receipt of consideration by the Company), the Plan will be appropriately adjusted in the type(s) and maximum number of securities subject to the Plan pursuant to subsection 4(a) and the outstanding Options will be appropriately adjusted in the
type(s) and number of securities and price per share of stock subject to such outstanding Options. Such adjustments shall be made by the Board or the Committee, the determination of which shall be final, binding and conclusive. (The conversion of
any convertible securities of the Company shall not be treated as a “transaction not involving the receipt of consideration by the Company.”) 
  
 (b) In the event of: (1) a dissolution, liquidation or sale of all or substantially all of the assets of the Company; (2) a merger or consolidation in
which the Company is not the surviving corporation; or (3) a reverse merger in which the Company is the surviving corporation but the shares of the Company’s common stock outstanding immediately preceding the merger are converted by virtue of
the merger into other property, whether in the form of securities, cash or otherwise; then: (i) any surviving corporation or acquiring corporation shall assume any Options outstanding under the Plan or shall substitute similar stock awards
(including an award to acquire the same consideration paid to the stockholders in the transaction described in this subsection 10(b)) for those outstanding under the Plan, or (ii) in the event any surviving corporation or acquiring corporation
refuses to assume such Options or to substitute similar stock awards for those outstanding under the Plan, (A) with respect to Options held by persons then performing services as Employees, Directors or Consultants, the vesting of such Options (and,
if applicable, the time during which such Options may be exercised) shall be accelerated prior to such event and the Options terminated if not exercised (if applicable) after such acceleration and at or prior to such event, and (B) with respect to
any other Options outstanding under the Plan, such Options shall be terminated if not exercised (if applicable) prior to such event. 
  
 (c) Change in Control Vesting. Unless otherwise provided in the applicable Option Agreement, each Option shall be subject to the special change in control
vesting provisions set forth in clause (1) below if the conditions set forth therein are satisfied (notwithstanding any other Continuous Status as an Employee, Director or Consultant vesting provisions herein to the contrary, but subject to any
limited exercise period following a termination of such status as may be provided for herein or in the applicable Option Agreement). 
  

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 (1) If an Option holder’s Continuous Status as an Employee, Director or Consultant is terminated by
the Company or an Affiliate upon or within one year after a Change in Control, and the termination is not the result of the holder’s death or disability and is not a termination by the Company or an Affiliate for Cause, then, subject to the
other provisions of this Section 10, all outstanding Options held by the holder shall be deemed fully vested immediately prior to such termination. 
  
 11.   AMENDMENT OF THE PLAN AND OPTIONs. 
  
 (a) The Board at any time, and from time to time, may amend the Plan.
However, except as provided in Section 10 relating to adjustments upon changes in stock, no amendment shall be effective unless approved by the stockholders of the Company to the extent approval is necessary for the Plan to satisfy the requirements
of Rule 16b-3 or any Nasdaq or securities exchange listing requirements. 
  
 (b) The Board may in its sole discretion submit any other amendment to the Plan for stockholder approval. 
  
 (c) Rights and obligations under any Option granted before amendment of the Plan shall not be impaired by any amendment of the Plan unless (i) the Company
requests the consent of the person to whom the Option was granted and (ii) such person consents in writing. 
  
 (d) The Board or Committee at any time, and from time to time, may amend the terms of any one or more Option; provided, however, that the rights and
obligations under any Option shall not be impaired by any such amendment unless (i) the Company requests the consent of the person to whom the Option was granted and (ii) such person consents in writing; provided further, that the Board or Committee
shall not have the power to reprice any Option once granted, except for adjustments resulting from a stock split, reverse stock split, or similar change to the outstanding capital stock, as provided in Section 10. 
  
 12.   TERMINATION OR
SUSPENSION OF THE PLAN. 
  
 (a) The Board may suspend or terminate the Plan at any time. Unless sooner terminated, the Plan shall terminate ten (10) years from the date the Plan is adopted by the Board. No Options may be granted under the Plan
while the Plan is suspended or after it is terminated. 
  
 (b)
Rights and obligations under any Option granted while the Plan is in effect shall not be impaired by suspension or termination of the Plan, except with the written consent of the person to whom the Option was granted. 
  
 13.   EFFECTIVE DATE OF
PLAN. 
  
 The Plan shall become effective as
of the date it is approved by the Board. 
  

 9Vicuron Pharmaceuticals Inc. Stock Option Grant Notice

 Exhibit 10.13 
  
 VICURON PHARMACEUTICALS INC. 
  

STOCK OPTION GRANT NOTICE 
 (2003
New-Hire Stock Option Plan) 
  
 Vicuron Pharmaceuticals Inc. (the
“Company”), pursuant to its 2003 New-Hire Stock Option Plan (the “Plan”), hereby grants to Optionee an option to purchase the number of shares of the Company’s common stock set forth below. This option is subject to all of
the terms and conditions as set forth herein and in Attachments I, II and III, which are incorporated herein in their entirety. The option is a Nonstatutory Stock Option and is not an incentive stock option within the meaning of Section 422 of the
Internal Revenue Code of 1986, as amended. 
  

					
	 Optionee:
	 	

	 Date of Grant:
	 	

	 Shares Subject to Option:
	 	

	 Exercise Price Per Share:
	 	$ 	 	

	 Expiration Date:
	 	

  
 Vesting
Schedule: 25% vests 12 months from the Date of Grant; 75% vests at a monthly rate of 1/36th each month thereafter. 
  
 Payment: By cash or check. 
  
 Additional Terms/Acknowledgements: The undersigned Optionee acknowledges receipt of, and understands and agrees to, this Grant Notice, the Stock Option
Agreement and the Plan. Optionee further acknowledges that as of the Date of Grant, this Grant Notice, the Stock Option Agreement and the Plan set forth the entire understanding between Optionee and the Company regarding the acquisition of stock in
the Company and supersede all prior oral and written agreements on that subject with the exception of any options granted concurrently with the option under the Company’s 2003 New-Hire Stock Option Plan and evidenced by an award agreement
executed by the Company and in a form similar to this notice. Optionee also agrees to the terms of the option set forth herein, in the Stock Option Agreement, and in the Plan. 
  

							
	 VICURON PHARMACEUTICALS INC.
	 	 	 	[OPTIONEE]:
				
	By:	 	  

	 	 	 	  

	 	 	 	 	 	 	 Signature

				
	Title:	 	  

	 	 	 	  

				
	Date:	 	  

	 	 	 	 Date:

  

			
	Attachment I:	  	Stock Option Agreement
	 Attachment II:
	  	2003 New-Hire Stock Option Plan
	 Attachment III:
	  	Notice of Exercise

  

 ATTACHMENT I 
  
 Stock Option Agreement 
  

 STOCK OPTION AGREEMENT 
  
 Pursuant to the Grant Notice and this Stock Option Agreement, the Company has granted you an option to purchase the number
of shares of the Company’s common stock (“Common Stock”) indicated in the Grant Notice at the exercise price indicated in the Grant Notice. 
  
 Your option is granted in connection with and in furtherance of the Company’s 2003 New-Hire Stock Option Plan (the “Plan”) for the
Company’s employees. Defined terms not explicitly defined in this Stock Option Agreement but defined in the Plan shall have the same definitions as in the Plan. 
  
 The details of your option are as follows: 
  
 1.    VESTING. Subject to the limitations contained herein, your
option will vest as provided in the Grant Notice, provided that vesting will cease upon the termination of your Continuous Status as an Employee, Director or Consultant. The vesting schedule requires continued employment or service through each
applicable vesting date as a condition to the vesting of the applicable installment of the options and the rights and benefits under this Stock Option Agreement. Employment or service, even if substantial, for only a portion of a vesting period will
not entitle you to any proportionate vesting or avoid or mitigate a termination of rights and benefits upon or following a termination of employment or service as provided herein. 
  
 2.    METHOD OF PAYMENT. Payment of the exercise
price by cash or check is due in full upon exercise of all or any part of your option. 
  
 3.    WHOLE SHARES; RIGHTS WITH RESPECT TO SHARES. Your option may only be exercised
for whole shares. You will have no rights or privileges of a stockholder of the Company as to any shares underlying the option until the issuance and delivery of a certificate evidencing the shares registered in your name following the exercise of
the option. No adjustment will be made for dividends or other rights as to a stockholder for which a record date is prior to such date of delivery. 
  
 4.    SECURITIES LAW COMPLIANCE. Notwithstanding anything to the contrary
contained herein, your option may not be exercised unless the shares issuable upon exercise of your option are then registered under the Securities Act of 1933, as amended (the “Securities Act”), or, if such shares are not then so
registered, the Company has determined that such exercise and issuance would be exempt from the registration requirements of the Securities Act. 
  
 5.    TERM. Subject to Section 10 of the Plan, the term of your option
commences on the Date of Grant and expires upon the earliest of: 
  
 (i)    the Expiration Date indicated in the Grant Notice; 
  
 (ii)    the tenth (10th) anniversary of the Date of Grant; 
  
 (iii)    eighteen (18) months after your death, if you die during, or within three (3) months after the termination of your
Continuous Status as Employee, Director or Consultant; 
  

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 (iv) twelve (12) months after the termination of your Continuous Status as Employee, Director or
Consultant due to disability; 
  
 (v) immediately after the
termination of your Continuous Status as Employee, Director or Consultant for Cause; or 
  
 (vi) three (3) months after the termination of your Continuous Status as an Employee, Director or Consultant for any other reason, provided that if during any part of such three (3)-month period the option is not
exercisable solely because of the condition set forth in paragraph 4 (Securities Law Compliance), in which event the option shall not expire until the earlier of the Expiration Date or until it shall have been exercisable for an aggregate period of
three (3) months after the termination of Continuous Status as an Employee, Director or Consultant. 
  
 In all cases, the option, to the extent not exercisable on the date your Continuous Status as an Employee, Director or Consultant terminates (regardless
of the reason), shall terminate on that date. 
  
 6.    EXERCISE. 
  
 (a) You may exercise the vested portion of your option during its term by delivering a notice of exercise (in a form designated by the Company) together with the exercise price to the Secretary of the Company, or to such other person as the
Company may designate, during regular business hours, together with such additional documents as the Company may then require. 
  
 (b) As a condition to any exercise of your option, the Company may require you to enter an arrangement providing for the payment by you to the Company of
any tax withholding obligation of the Company (and/or any of its Affiliates) arising by reason of the exercise of your option. 
  
 7.    TRANSFERABILITY. Your option is not transferable, except by will or by the laws of descent and
distribution, and is exercisable during your life only by you. Notwithstanding the foregoing, by delivering written notice to the Company, in a form satisfactory to the Company, you may designate a third party who, in the event of your death, shall
thereafter be entitled to exercise your option. 
  
 8.    OPTION NOT A SERVICE CONTRACT. Your option is not an employment contract and nothing in your option shall be deemed to create in any
way whatsoever any obligation on your part to continue in the employ of the Company or one of its Affiliates, or of the Company and its Affiliates to continue your employment with the Company or any of its Affiliates. In addition, nothing in your
option shall obligate the Company, any Affiliate, and their respective shareholders, board of directors, officers or employees to continue any relationship which you might have as a director or consultant for the Company or one of its Affiliates.

  
 9.    NOTICES. Any
notices provided for in your option or the Plan shall be given in writing and shall be deemed effectively given upon receipt or, in the case of notices delivered by the Company to you, five (5) days after deposit in the United States mail, postage
prepaid, addressed to you at the last address you provided to the Company. 
  

 2 

 10.    GOVERNING PLAN DOCUMENT.
Your option is subject to all the provisions of the Plan, the provisions of which are hereby made a part of your option, including without limitation the provisions of the Plan relating to option provisions, and is further subject to all
interpretations, amendments, rules and regulations which may from time to time be promulgated and adopted pursuant to the Plan. In the event of any conflict between the provisions of your option and those of the Plan, the provisions of the Plan
shall control. Unless otherwise expressly provided in this Stock Option Agreement, provisions of the Plan that confer discretionary authority on the Board (or a committee thereof) do not (and shall not be deemed to) create any additional rights for
you not expressly set forth in this Stock Option Agreement. 
  
  

 3 

 ATTACMENT II 
  
 2003 New-Hire Stock Option Plan 
  

 ATTACHMENT III 
  
 Notice of Exercise 
  

 NOTICE OF EXERCISE OF OPTION 
 GRANTED UNDER THE 2003 NEW-HIRE STOCK OPTION PLAN 
  
 Date of
Exercise:                                      
       
  
 Vicuron Pharmaceuticals Inc. 
 455 South Gulph Road, Suite 310 
 King of Prussia, PA 19406 
  
 Ladies and Gentlemen: 
  
 This constitutes notice under my stock option that I elect to purchase the number of shares for the price set forth below. 
  

					
	Stock option dated:	  	
	  	 
			
	 Number of shares as
 to which
option is
 exercised:
	  	
	  	 
			
	 Certificates to be
 issued in name
of:
	  	
	  	 
			
	Total exercise price:	  	 $                                      
                  

	  	 
			
	 Cash payment delivered
 herewith:
	  	 $                                      
                  

	  	 

  
 By this exercise, I
agree (i) to provide such additional documents as you may require pursuant to the terms of the 2003 New-Hire Stock Option Plan, and (ii) to provide for the payment by me to you (in the manner designated by you) of your withholding obligation, if
any, relating to the exercise of this option. I understand that Vicuron Pharmaceuticals Inc. will not be bound to honor this exercise unless and until I have either paid all such tax withholding obligations in cash and/or I have otherwise provided
for such withholding obligations in the manner designated by you. 
  

			
	 Very truly yours,

	
	
 (Signature)

  

			
		
	Print Name:	 	 
	 	 	

		
	Address:

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