Document:

Office Lease, dated as of March 1, 2002

 EXHIBIT 10.14 
  
 OFFICE LEASE 
  
 601 GATEWAY BOULEVARD 
  
 GATEWAY CENTER, LLC, 
 a California
limited liability company 
  
 as Landlord, 
  
 and 
  
 D-NOVO THERAPEUTICS, INC. 
  
 a Delaware corporation 
  
 as Tenant. 

 TABLE OF CONTENTS 
  

			
	 	  	Page

	 ARTICLE 1 PREMISES, BUILDING, PROTECT, AND COMMON AREAS
	  	3
		
	 ARTICLE 2 LEASE TERM
	  	8
		
	 ARTICLE 3 BASE RENT
	  	8
		
	 ARTICLE 4 ADDITIONAL RENT
	  	9
		
	 ARTICLE 5 USE OF PREMISES
	  	16
		
	 ARTICLE 6 SERVICES AND UTILITIES
	  	17
		
	 ARTICLE 7 REPAIRS
	  	19
		
	 ARTICLE 8 ADDITIONS AND ALTERATIONS
	  	20
		
	 ARTICLE 9 COVENANT AGAINST LIENS
	  	23
		
	 ARTICLE 10 INSURANCE
	  	24
		
	 ARTICLE 11 DAMAGE AND DESTRUCTION
	  	26
		
	 ARTICLE 12 NONWAIVER
	  	28
		
	 ARTICLE 13 CONDEMNATION
	  	28
		
	 ARTICLE 14 ASSIGNMENT AND SUBLETTING
	  	29
		
	 ARTICLE 15 SURRENDER OF PREMISES; OWNERSHIP AND REMOVAL OF TRADE FIXTURES
	  	34
		
	 ARTICLE 16 HOLDING OVER
	  	35
		
	 ARTICLE 17 ESTOPPEL CERTIFICATES
	  	35
		
	 ARTICLE 18 MORTGAGE OR GROUND LEASE
	  	36
		
	 ARTICLE 19 DEFAULTS; REMEDIES
	  	37
		
	 ARTICLE 20 COVENANT OF QUIET ENJOYMENT
	  	40
		
	 ARTICLE 21 LETTER OF CREDIT
	  	40
		
	 ARTICLE 22 SUBSTITUTION OF OTHER PREMISES
	  	41
		
	 ARTICLE 23 SIGNS
	  	42

  

 -ii- 

			
	 ARTICLE 24 COMPLIANCE WITH LAW
	  	43
		
	 ARTICLE 25 LATE CHARGES
	  	43
		
	 ARTICLE 26 LANDLORD’S RIGHT TO CURE DEFAULT; PAYMENTS BY TENANT
	  	44
		
	 ARTICLE 27 ENTRY BY LANDLORD
	  	44
		
	 ARTICLE 28 NOTICES
	  	45
		
	 ARTICLE 29 MISCELLANEOUS PROVISIONS
	  	46

  

 -iii- 

 INDEX 
  

			
	 	  	Page(s)

	 A
	  	18
	 Additional Rent
	  	9
	 Advocate Arbitrators
	  	6
	 all risks
	  	25
	 Alterations
	  	20
	 as built
	  	21
	 Bank Prime Loan
	  	43
	 Base Building
	  	20, 21
	 Base Building
	  	21
	 Base Rent
	  	8
	 Base Year
	  	9
	 Base Year Prop 13 Taxes
	  	14
	 Base Year
	  	9
	 Brokers
	  	50
	 Builder’s All Risk
	  	22
	 Building
	  	3
	 Building Common Areas
	  	4
	 Building Direct Expenses
	  	9
	 Building Hours
	  	17
	 Building Operating Expenses
	  	9
	 building standard
	  	16
	 Building Tax Expenses
	  	9
	 Building
	  	3
	 Common Areas
	  	3
	 Comparable Transactions
	  	5
	 Concessions
	  	5
	 Cost Pools
	  	14
	 Direct Expenses
	  	9
	 Estimate
	  	15
	 Estimate Statement
	  	15
	 Estimated Excess
	  	15
	 Excess
	  	15
	 Expense Year
	  	10
	 Expense Year
	  	9
	 Force Majeure
	  	48
	 Gateway Center
	  	50
	 Hazardous Substance
	  	17
	 Holidays
	  	17
	 HVAC
	  	17
	 Landlord
	  	1, 46, 53

  

 -iv- 

			
	 	  	Page(s)

	 Landlord Parties
	  	24
	 Landlord Repair Notice
	  	26
	 Lease
	  	1
	 Lease Commencement Date
	  	8
	 Lease Expiration Date
	  	8
	 Lease Term
	  	8
	 Lease Year
	  	8
	 Lines
	  	52
	 Mail
	  	45
	 mortgage
	  	36
	 Neutral Arbitrator
	  	6
	 Notices
	  	45
	 Operating Expenses
	  	9, 10
	 Original Improvements
	  	25
	 Other Improvements
	  	51
	 Outside Agreement Date
	  	6
	 Premises
	  	3
	 Project Common Areas
	  	4
	 Project
	  	3
	 Proposition 13
	  	13
	 Reassessment
	  	14
	 Renovations
	  	51
	 rent
	  	39
	 Rent
	  	9, 42
	 rentable square feet
	  	4
	 Security Deposit
	  	42
	 Statement
	  	15
	 Subject Space
	  	29
	 Summary
	  	1
	 Tax Expenses
	  	9, 11, 12
	 tenant
	  	1, 46, 53
	 Tenant’s Security System
	  	18
	 Tenant’s Share
	  	9, 14, 42
	 Tenant’s Subleasing Costs
	  	31
	 Transfer
	  	33
	 Transfer Agreement
	  	32
	 Transfer Notice
	  	29
	 Transfer Premium
	  	29, 31
	 Transfer
	  	29
	 Transferee
	  	29
	 Transfers
	  	29
	 worth at the time of award
	  	39

  

 -v- 

 601 GATEWAY BOULEVARD 
  
 OFFICE LEASE 
  
 This Office Lease (the “Lease”), dated as of the date set forth in Section 1 of the Summary of Basic Lease Information (the
“Summary”), below, is made by and between GATEWAY CENTER, LLC, a California limited liability company (“Landlord”), and D-NOVO THERAPEUTICS, INC., a Delaware corporation (“Tenant”). 
  
 SUMMARY OF BASIC LEASE INFORMATION 
  

							
	TERMS OF LEASE	  	DESCRIPTION
				
	1.	  	Date:	 	 	  	March 1, 2002.
			
	2.	  	Premises(Article 1).	  	 
				
	 	  	2.1	 	Building:	  	601 Gateway Boulevard
				
	 	  	2.2	 	Premises:	  	4,319 rentable square feet of space located on the fourth (4th) floor of the Building and commonly known as Suite 450, as further set forth in Exhibit A to the Office Lease.
			
	3.	  	Lease Term(Article 2).	  	 
				
	 	  	3.1	 	Length of Term:	  	Three (3) years, and sixteen (16) days.
				
	 	  	3.2	 	Lease Commencement Date:	  	March 16, 2002.
				
	 	  	3.3	 	Lease Expiration Date:	  	March 31, 2005.
		
	4.	  	Base Rent (Article 3):

  

										
	Period During
Lease Term

	  	 Annual
 Base Rent

	  	Monthly
Installment
of Base Rent

	  	Annual Base Rental
Rate Per Rentable
Square Foot

	1	  	$	139,935.60	  	$	11,661.30	  	$	2.70
				
	2	  	$	144,081.84	  	$	12,006.82	  	$	2.78
				
	3	  	$	148,228.08	  	$	12,352.34	  	$	2.86

  

					
	5.	  	 Base Year
 (Article 4):
	    	Calendar year 2002.

  

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	6.	  	 Tenant’s Share
 (Article 4):
	  	Approximately 2%.
			
	7.	  	 Permitted Use
 (Article 5):
	  	General office use.
			
	8.	  	 Letter of Credit
 (Article 21):
	  	$111,171.06.
			
	9.	  	 Address of Tenant
 (Article
28):
	  	 D-Novo Therapeutics, Inc.
 601 Gateway Center, Suite
450
 South San Francisco, California
 Attention: Mr. Brad
Goodwin
  
 with a copy to:
  
 Crosby, Heafey, Roach & May
 Professional Corporation
 Two Embarcadero Center, Suite 2000
 San Francisco, California 94109
 Attention: Charles H. Seaman, Esq.
  
 (Prior to and After Lease Commencement Date)

			
	10.	  	 Address of Landlord
 (Article
28):
	  	See Article 28 of the Lease.
			
	11.	  	 Broker(s)
 (Section 29.24):
	  	 BT Commercial
 1350 Bayshore Highway, Suite
150
 Burlingame, California 94010
 Attention: Mr. David
Lardner
  
 and
  
 CB Richard Ellis, Inc.
 950 Tower Lane, Suite
870
 Foster City, California 94404
 Attention: Mr. James
Lees

  

 -2- 

 ARTICLE 1 
  
 PREMISES, BUILDING, PROJECT, AND COMMON AREAS; RIGHT OF FIRST OFFER 
  
 1.1 Premises, Building, Project and Common Areas. 

 
 1.1.1 The Premises. Landlord hereby leases to Tenant and
Tenant hereby leases from Landlord the premises set forth in Section 2.2 of the Summary (the “Premises”). The outline of the Premises is set forth in Exhibit A attached hereto and each floor or floors of the Premises has the number of
rentable square feet as set forth in Section 2.2 of the Summary. The parties hereto agree that the lease of the Premises is upon and subject to the terms, covenants and conditions herein set forth, and Tenant covenants as a material part of the
consideration for this Lease to keep and perform each and all of such terms, covenants and conditions by it to be kept and performed and that this Lease is made upon the condition of such performance. The parties hereto hereby acknowledge that the
purpose of Exhibit A is to show the approximate location of the Premises in the “Building,” as that term is defined in Section 1.1.2, below, only, and such Exhibit is not meant to constitute an agreement, representation or warranty as
to the construction of the Premises, the precise area thereof or the specific location of the “Common Areas,” as that term is defined in Section 1.1.3, below, or the elements thereof or of the accessways to the Premises or the
“Project,” as that term is defined in Section 1.1.2, below. Except as specifically set forth in this Lease Landlord shall not be obligated to provide or pay for any improvement work or services related to the improvement of the
Premises. Tenant also acknowledges that neither Landlord nor any agent of Landlord has made any representation or warranty regarding the condition of the Premises, the Building or the Project or with respect to the suitability of any of the
foregoing for the conduct of Tenant’s business, except as specifically set forth in this Lease. The taking of possession of the Premises by Tenant shall conclusively establish that the Premises and the Building were at such time in good and
sanitary order, condition and repair. 
  
 1.1.2 The Building
and The Project. The Premises are a part of the building set forth in Section 2.1 of the Summary (the “Building”). The Building is part of an office project known as “Gateway Center.” The term “Project,” as
used in this Lease, shall mean (i) the Building and the Common Areas, (ii) the land (which is improved with landscaping, subterranean parking facilities and other improvements) upon which the Building and the Common Areas are located,
(iii) those certain other office buildings located in the vicinity of the Building and known as 651 Gateway Boulevard, respectively, and the land upon which such office buildings are located, and (iv) at Landlord’s discretion, any
additional real property, areas, land, buildings or other improvements added thereto outside of the Project. 
  
 1.1.3 Common Areas. Tenant shall have the non-exclusive right to use in common with other tenants in the Project, and subject to the rules
and regulations referred to in Article 5 of this Lease, those portions of the Project which are provided, from time to time, for use in common by Landlord, Tenant and any other tenants of the Project (such areas, together with such other portions of
the Project designated by Landlord, in its discretion, including certain areas designated for the exclusive use of certain tenants, or to be shared by Landlord and certain tenants, are collectively referred to herein as the “Common
Areas”). The Common Areas shall consist of the “Project Common Areas” and the “Building Common Areas.” The term “Project 
  

 -3- 

 Common Areas,” as used in this Lease, shall mean the portion of the Project designated as such by Landlord, which
Project Common Areas may include, from time to time, in Landlord’s sole discretion, a conference center and other amenities. The term “Building Common Areas,” as used in this Lease, shall mean the portions of the Common Areas located
within the Building designated as such by Landlord. The manner in which the Common Areas are maintained and operated shall be at the sole discretion of Landlord and the use thereof shall be subject to such rules, regulations and restrictions as
Landlord may make from time to time. Landlord reserves the right to close temporarily, make alterations or additions to, or change the location of elements of the Project and the Common Areas. 
  
 1.2 Verification of Rentable Square Feet of Premises and
Building. For purposes of this Lease, “rentable square feet” in the Premises and the Building, as the case may be, shall be calculated pursuant to Landlord’s then current method for measuring rentable square footage.
Landlord and Tenant hereby stipulate and agree that the rentable area of the Premises is as set forth in Section 2.2 of the Summary. Notwithstanding the foregoing, if Landlord, at its option, re-measures the Premises in connection with a
re-measurement of the Building to determine the exact amount of rentable area contained therein pursuant to Landlord’s then current method for measuring rentable square footage, or if the rentable area of the Premises and/or the Building shall
hereafter change due to subsequent alterations and/or other modifications to the Premises and/or the Building, then the rentable area of the Premises and/or the Building, as the case may be, shall be appropriately adjusted as of the date of such
re-measurement or such alteration and/or other modification, based upon the written verification by Landlord’s space planner of such revised rentable area. In the event of any such adjustment to the rentable area of the Premises and/or the
Building, all amounts, percentages and figures appearing or referred to in this Lease based upon such rentable area (including, without limitation, the amounts of the “Rent” and the “Security Deposit,” as those terms are defined
in Article 4 and Article 21 of this Lease, respectively, and “Tenant’s Share,” as that term is defined in Section 4.2.9 of this Lease) shall be modified in accordance with such determination; provided, however, if any such
adjustment to the rentable area of the Premises and/or the Building results from a re-measurement thereof conducted at Landlord’s option, then, notwithstanding anything to the contrary contained in this Section 1.2, “Base Rent,”
as defined in Article 3 of this Lease, shall not be modified in accordance with such determination. 
  
 1.3 Right of First Offer; Option Term. Landlord hereby grants to the Tenant originally named herein (the “Original Tenant”)
or its “Affiliate,” as that term is defined in Section 14.8 of this Lease, a right of first offer regarding the extension of the Lease Term (the “Option Term”); and a separate and distinct right of first offer to lease
approximately 3,060 rentable square feet of space located on the fourth (4th) floor of the Building, designated as Suite 460, and as shown on Exhibit A-1, attached hereto (the “First Offer Space”), upon the terms and conditions set
forth in this Section 1.3. 
  
 1.3.1 Method of
Exercise. The rights contained in this Section 1.3 shall be exercised only by Original Tenant and only in the following manner: (i) Landlord shall deliver to Tenant a notice (the “First Offer Notice”) not more than twelve
(12) months nor less than nine (9) months prior to the Lease Expiration Date, which First Offer Notice shall state the rent (calculated as the “Fair Rental Value,” as that term is defined in Section 1.3.2 below, of the
Premises (the “Option Rent”) and the First Offer Space, as applicable, as of the date of the 
  

 -4- 

 commencement of the Option Term or the date of delivery of the First Offer Space, as applicable, as determined by
Landlord, and Landlord shall provide, upon request, documentation indicating a reasonable number of comparable transactions to substantiate Landlord’s determination) and other economic terms upon which Landlord shall offer to lease (A) the
Premises, during the Option Term; and (B) the First Offer Space to Tenant; and (ii) Tenant shall, within twenty (20) days following Tenant’s receipt of the First Offer Notice, exercise the option by delivering written notice
thereof to Landlord. Tenant shall have the right to exercise the first offer right as to (I) both the Premises, for the Option Term, and the First Offer Space; or (II) just the Premises, for the Option Term. Tenant shall not have the right to
lease the First Offer Space in the event Tenant elects not to lease the Premises during the Option Term. 
  
 1.3.2 Fair Rental Value. The “Fair Rental Value,” as used in this Lease, shall be equal to the annual rent per rentable square
foot (including additional rent and considering any “base year” or “expense stop” applicable thereto), including all escalations, at which tenants or potential tenants are leasing non-sublease, non-encumbered, non-equity space
which is not significantly greater or smaller in size than the subject space, for a comparable lease term, in an arm’s length transaction, which comparable space is located in the Project (“Comparable Transactions”), taking into
consideration the following concessions (the “Concessions”): (a) rental abatement concessions, if any, being granted such tenants in connection with such comparable space; (b) tenant improvements or allowances provided or to be
provided for such comparable space, and taking into account the value, if any, of the existing improvements in the subject space, such value to be based upon the age, condition, design, quality of finishes and layout of the improvements and the
extent to which the same can be utilized by a general office user other than Tenant; and (c) other reasonable monetary concessions being granted such tenants in connection with such comparable space; provided, however, that in calculating the
Fair Rental Value, no consideration shall be given to (i) the fact that Landlord is or is not required to pay a real estate brokerage commission in connection with Tenant’s exercise of its right to extend the Lease Term or in connection
with Tenant’s lease of the First Offer Space, as the case may be, or the fact that landlords are or are not paying real estate brokerage commissions in connection with such comparable space, and (ii) except in connection with the
determination of the Fair Rental Value for the First Offer Space, any period of rental abatement, if any, granted to tenants in comparable transactions in connection with the design, permitting and construction of tenant improvements in such
comparable spaces. The Fair Rental Value shall additionally (A) consider in its calculation the $5.00 per rentable square foot improvement allowance to be paid to Tenant pursuant to the terms of Section 1.3.3 of this Lease, in connection
with the extension of the Lease Term or Tenant’s lease of the First Offer Space, as applicable, and (B) include a determination as to whether, and if so to what extent, Tenant must provide Landlord with financial security, such as a letter
of credit or guaranty, for Tenant’s Rent obligations in connection with Tenant’s lease of the First Offer Space or Tenant’s lease of the Premises the Option Term, as the case may be. Such determination shall be made by reviewing the
extent of financial security then generally being imposed in Comparable Transactions from tenants of comparable financial condition and credit history to the then existing financial condition and credit history of Tenant (with appropriate
adjustments to account for differences in the then-existing financial condition of Tenant and such other tenants). The Concessions (I) shall be reflected in the effective rental rate (which effective rental rate shall take into consideration
the total dollar value of such Concessions as amortized on a straight-line basis over the applicable term of the Comparable Transaction (in which case such Concessions evidenced in the effective rental rate shall not be granted to Tenant)) payable
by Tenant, or (II) at Landlord’s election, all such Concessions shall be granted to Tenant in kind. 
  

 -5- 

 1.3.2.1 Determination of Option Rent. In the event Tenant timely and appropriately
exercises its option to extend the Lease Term, Landlord shall, on or about the commencement date of the Option Term, notify Tenant of Landlord’s determination of the Option Rent, and Tenant shall have the right to object to such determination
by notice to Landlord within ten (10) days following receipt of Landlord’s determination. If Tenant timely and in good faith objects to Landlord’s determination of the Option Rent, then Landlord and Tenant shall attempt to agree upon
the Option Rent, using their best good-faith efforts. If Landlord and Tenant fail to reach agreement within thirty (30) days following Tenant’s objection to the Option Rent, (the “Outside Agreement Date”), then each party shall
make a separate determination of the Option Rent within five (5) days, and such determinations shall be submitted to arbitration in accordance with Sections 1.3.2.1.1 through 1.3.2.1.7, below. 
  
 1.3.2.1.1 Landlord and Tenant shall each appoint one arbitrator who shall
be, at the option of the appointing party, a real estate broker or appraiser who shall have been active over the five (5) year period ending on the date of such appointment in the leasing or appraisal, as the case may be, of commercial
high-rise properties in the San Francisco Bay Area of California. The determination of the arbitrators shall be limited solely to the issue of what the actual Option Rent, should be, taking into account the requirements of Section 1.3.2 of this
Lease. Each such arbitrator shall be appointed within fifteen (15) days after the Outside Agreement Date. Landlord and Tenant may consult with their selected arbitrators prior to appointment and may select an arbitrator who is favorable to
their respective positions. The arbitrators so selected by Landlord and Tenant shall be deemed “Advocate Arbitrators.” 
  
 1.3.2.1.2 The two (2) Advocate Arbitrators so appointed shall be specifically required pursuant to an engagement letter within ten (10) days of
the date of the appointment of the last appointed Advocate Arbitrator to agree upon and appoint a third arbitrator (“Neutral Arbitrator”) who shall be qualified under the same criteria set forth hereinabove for qualification of the two
Advocate Arbitrators, except that neither the Landlord or Tenant or either parties’ Advocate Arbitrator may, directly or indirectly, consult with the Neutral Arbitrator prior or subsequent to his or her appearance. The Neutral Arbitrator shall
be retained via an engagement letter jointly prepared by Landlord’s counsel and Tenant’s counsel. 
  
 1.3.2.1.3 Within thirty (30) days of the appointment of the Neutral Arbitrator, each of the three (3) arbitrators shall render and deliver to
Landlord, Tenant and the other two (2) arbitrators a written appraisal of what the actual Option Rent should be, taking into account the requirements of Section 1.3.2. Thereafter, the three (3) arbitrators shall discuss the written
appraisals until such time as two (2) or more of the arbitrators either have agreed upon one (1) of the written appraisals previously prepared in accordance with this Section 1.3.2.1 or have rendered a separate written appraisal upon
which at least two (2) such arbitrators agree. 
  
 1.3.2.1.4
The Option Rent shall be equal to the appraised value upon which two (2) or more of the arbitrators agree. 
  

 -6- 

 1.3.2.1.5 If either Landlord or Tenant fails to appoint an Advocate Arbitrator within fifteen
(15) days after the Outside Agreement Date, then either party may petition the presiding judge of the Superior Court of San Francisco County to appoint such Advocate Arbitrator subject to the criteria in Section 1.3.2.1 of this Lease, or
if he or she refuses to act, either party may petition any judge having jurisdiction over the parties to appoint such Advocate Arbitrator. 
  
 1.3.2.1.6 If the two (2) Advocate Arbitrators fail to agree upon and appoint the Neutral Arbitrator, then either party may petition the presiding
judge of the Superior Court of San Francisco County to appoint the Neutral Arbitrator, subject to criteria in Section 1.3.2.1 of this Lease, or if he or she refuses to act, either party may petition any judge having jurisdiction over the
parties to appoint such arbitrator. 
  
 1.3.2.1.7 The cost of the
arbitration shall be paid by Landlord and Tenant equally. 
  
 1.3.3 Improvements in the First Offer Space. Tenant shall take (i) the Premises, as of the commencement of the Option Term, and (ii) the First Offer Space, as applicable, in their “as is” condition;
provided that Tenant shall be entitled to a tenant improvement allowance in an amount equal to $5.00 per rentable square foot of the Premises and First Offer Space, as applicable, and the construction of improvements in the Premises and First Offer
Space, as applicable, shall comply with the terms of Article 8 of this Lease. 
  
 1.3.4 Amendment to Lease. If Tenant timely exercises Tenant’s right to extend the Lease Term and/or to lease the First Offer Space, as applicable, as set forth herein, then, within fifteen
(15) days thereafter, Landlord and Tenant shall execute an amendment extending the Lease Term and/or adding such First Offer Space to this Lease upon the same terms and conditions as the Premises, except as otherwise set forth in this
Section 1.3. With respect to the First Offer Space, for purposes of calculating Tenant’s obligations under Article 4 of this Lease, Tenant’s Share of Direct Expenses shall be increased by an amount equal to the rentable square footage
of the First Offer Space divided by the total rentable square footage of the Building. Except to the extent inconsistent with the determination of the rent payable for the First Offer Space, all provisions of this Lease which vary based upon the
rentable and usable square footage of the Premises shall be adjusted to reflect the addition of such First Offer Space to the Premises. Tenant shall commence payment of rent for the First Offer Space to Lessor and the term of the First Offer Space
shall commence upon that date (the “First Offer Space Commencement Date”) Which date shall be the date upon which Landlord delivers the First Offer Space to Tenant. The lease term of the First Offer Space shall be coterminous with
Lessee’s lease of the Premises. 
  
 1.3.5
Landlord’s Right to Offer First Offer Space Early. Notwithstanding anything to the contrary contained in this Section 1.3, in the event the existing lease of the First Offer Space terminates prior to the scheduled expiration
date, Landlord shall have the right to offer to Tenant the First Offer Space following such early termination, and Tenant shall have twenty (20) days to deliver written notice to Landlord exercising Tenant’s right to lease the First Offer
Space. In such event, Tenant shall lease the First Offer Space on an “as-is” basis and no tenant improvement allowance shall be paid to Tenant with respect to the First Offer Space for 
  

 -7- 

 the remainder of the initial Lease Term. In the event Tenant fails to timely deliver the Exercise Notice, Landlord shall
be free to lease the First Offer Space to a third party and Tenant’s rights to the First Offer Space shall be of no further force and effect. 
  
 ARTICLE 2 
  
 LEASE TERM 
  
 The terms and provisions of this Lease shall be effective as of the date of this Lease. The term of this Lease (the “Lease Term”) shall be as
set forth in Section 3.1 of the Summary, shall commence on the date set forth in Section 3.2 of the Summary (the “Lease Commencement Date”), and shall terminate on the date set forth in Section 3.3 of the Summary (the
“Lease Expiration Date”) unless this Lease is sooner terminated as hereinafter provided. Tenant shall have the right to occupy the Premises not more than two (2) weeks prior to the Lease Commencement Date, provided that (A) a
temporary certificate of occupancy shall have been issued by the appropriate governmental authorities for each such portion to be occupied, and (B) all of the terms and conditions of the Lease shall apply, other than Tenant’s obligation to
pay “Base Rent,” as that term is defined in Article 3 below, and “Tenant’s Share” of the annual “Building Direct Expenses,” as those terms are defined in Article 4, below, as though the Lease Commencement Date had
occurred (although the Lease Commencement Date shall not actually occur until the occurrence of the same pursuant to the terms of the second sentence of this Article 2) upon such occupancy of a portion of the Premises by Tenant. For purposes of this
Lease, the term “Lease Year” shall mean each consecutive twelve (12) month period during the Lease Term. At any time during the Lease Term, Landlord may deliver to Tenant a notice in the form as set forth in Exhibit C, attached
hereto, as a confirmation only of the information set forth therein, which Tenant shall execute and return to Landlord within five (5) business days of receipt thereof; provided, however, Tenant’s failure to execute and return such notice
to Landlord within such time shall be conclusive upon Tenant that the information set forth in such notice is as specified therein. 
  
 ARTICLE 3 
  
 BASE RENT 
  
 3.1 In General. Tenant shall pay, without prior notice or demand, to Boston Properties – Bank of America, c/o Gateway Center, File
No. 73807, P.O. Box 60000, San Francisco, California 94160-3669, or, at Landlord’s option, to such other party or at such other place as Landlord may from time to time designate in writing, by a check for currency which, at the time of
payment, is legal tender for private or public debts in the United States of America, base rent (“Base Rent”) as set forth in Section 4 of the Summary, payable in equal monthly installments as set forth in Section 4 of the
Summary in advance on or before the first day of each and every calendar month during the Lease Term, without any setoff or deduction whatsoever. The Base Rent for the first full month of the Lease Term shall be paid at the time of Tenant’s
execution of this Lease. If any Rent payment date (including the Lease Commencement Date) falls on a day of the month other than the first day of such month or if any payment of Rent is for a period which is shorter than one month, the Rent for any
fractional month shall accrue on a daily basis for the period from the date such payment is due to the end of such 
  

 -8- 

 calendar month or to the end of the Lease Term at a rate per day which is equal to 1/365 of the applicable annual Rent.
All other payments or adjustments required to be made under the terms of this Lease that require proration on a time basis shall be prorated on the same basis. 
  

3.2 Abated Rent. Landlord agrees that, provided that Tenant is not in default under this Lease, then for the first (1st) month of the initial Lease Term, Tenant shall have no obligation to pay Base Rent and Tenant’s Share of Direct
Expenses otherwise attributable to the first (1st) month of the initial Lease Term. 
  
 ARTICLE 4 
  
 ADDITIONAL RENT 
  
 4.1 General Terms. In addition to paying the Base Rent
specified in Article 3 of this Lease, Tenant shall pay “Tenant’s Share” of the annual “Building Direct Expenses,” as those terms are defined in Sections 4.2.9 and 4.2.2 of this Lease, respectively, which are in excess of the
amount of Building Direct Expenses applicable to the “Base Year,” as that term is defined in Section 4.2.1, below; provided, however, that in no event shall any decrease in Building Direct Expenses for any “Expense Year,” as
that term is defined in Section 4.2.6 below, below Building Direct Expenses for the Base Year entitle Tenant to any decrease in Base Rent or any credit against sums due under this Lease. Such payments by Tenant, together with any and all other
amounts payable by Tenant to Landlord pursuant to the terms of this Lease, are hereinafter collectively referred to as the “Additional Rent”, and the Base Rent and the Additional Rent are herein collectively referred to as
“Rent.” All amounts due under this Article 4 as Additional Rent shall be payable for the same periods and in the same manner as the Base Rent. Without limitation on other obligations of Tenant which survive the expiration of the Lease
Term, the obligations of Tenant to pay the Additional Rent provided for in this Article 4 shall survive the expiration of the Lease Term. 
  
 4.2 Definitions of Key Terms Relating to Additional Rent. As used in this Article 4, the following terms shall have the meanings hereinafter
set forth: 
  
 4.2.1 “Base Year” shall mean the
period set forth in Section 5 of the Summary. 
  
 4.2.2
“Building Direct Expenses” shall mean “Building Operating Expenses” and “Building Tax Expenses”, as those terms are defined in Sections 4.2.3 and 4.2.4, below, respectively. 
  
 4.2.3 “Building Operating Expenses” shall mean the portion
of “Operating Expenses,” as that term is defined in Section 4.2.7 below, allocated to the tenants of the Building pursuant to the terms of Section 4.3.1 below. 
  
 4.2.4 “Building Tax Expenses” shall mean that portion of “Tax Expenses”, as that term is defined
in Section 4.2.8 below, allocated to the tenants of the Building pursuant to the terms of Section 4.3.1 below. 
  

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 4.2.5 “Direct Expenses” shall mean “Operating Expenses” and “Tax
Expenses.” 
  
 4.2.6 “Expense Year” shall
mean each calendar year in which any portion of the Lease Term falls, through and including the calendar year in which the Lease Term expires, provided that Landlord, upon notice to Tenant, may change the Expense Year from time to time, but not
during the, first twelve (12) months of the Lease Term, to any other twelve (12) consecutive month period, and, in the event of any such change, Tenant’s Share of Building Direct Expenses shall be equitably adjusted for any Expense
Year involved in any such change. 
  
 4.2.7 “Operating
Expenses” shall mean all expenses, costs and amounts of every kind and nature which Landlord pays or accrues during any Expense Year because of or in connection with the ownership, management, maintenance, security, repair, replacement,
restoration or operation of the Project, or any portion thereof. Without limiting the generality of the foregoing, Operating Expenses shall specifically include any and all of the following: (i) the cost of supplying all utilities, the cost of
operating, maintaining, repairing, replacing, renovating and managing the utility systems, mechanical systems, sanitary, storm drainage systems, communication systems and escalator and elevator systems, and the cost of supplies, tools, and equipment
and maintenance and service contracts in connection therewith; (ii) the cost of licenses, certificates, permits and inspections and the cost of contesting any governmental enactments which may affect Operating Expenses, and the costs incurred
in connection with a transportation system management program or similar program; (iii) the cost of all insurance carried by Landlord in connection with the Project as reasonably determined by Landlord (including, without limitation, commercial
general liability insurance, physical damage insurance covering damage or other loss caused by fire, earthquake, flood and other water damage, explosion, vandalism and malicious mischief, theft or other casualty, rental interruption insurance and
such insurance as may be required by any lessor under any present or future ground or underlying lease of the Building or Project or any holder of a mortgage, trust deed or other encumbrance now or hereafter in force against the Building or Project
or any portion thereof); (iv) the cost of landscaping, decorative lighting, relamping, fountains, sculptures, bridges and all supplies, tools, equipment and materials used in the operation, repair and maintenance of the Project, or any portion
thereof; (v) the cost of parking area repair, restoration, and maintenance, including, without limitation, resurfacing, repainting, restriping and cleaning; (vi) fees, charges and other costs, including management fees (or amounts in lieu
thereof), consulting fees (including, without limitation, any consulting fees incurred in connection with the procurement of insurance), legal fees and accounting fees, of all contractors, engineers, consultants and all other persons engaged by
Landlord or otherwise incurred by or charged by Landlord in connection with the management, operation, administration, maintenance and repair of the Building and the Project; (vii) payments under any equipment rental agreements or management
agreement’s (including the cost of any actual or charged management fee and the actual or charged rental of any management office space); (viii) wages, salaries and other compensation and benefits, including taxes levied thereon, of all
persons engaged in the operation, maintenance and security of the Project; (ix) costs under any instrument pertaining to the sharing of costs by the Project; (x) operation, repair, maintenance and replacement of all systems and equipment
and components thereof of the Project; (xi) the cost of janitorial, alarm, security and other services, replacement of wall and floor coverings, ceiling tiles and fixtures in common areas, maintenance and replacement of curbs and walkways,
repair to roofs and 
  

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 reroofing; (xii) amortization (including interest on the unamortized cost) of the cost of acquiring or the rental
expense of personal property used in the maintenance, operation and repair of the Project, or any portion thereof; (xiii) the cost of capital improvements or other costs incurred in connection with the Project (A) which are intended to
effect economies in the operation, cleaning or maintenance of the Project, or any portion thereof, (B) that are required to comply with present or anticipated conservation programs, (C) which are replacements or modifications of
nonstructural items located in the Common Areas required to keep the Common Areas in good order or condition, or (D) that are required under any governmental law or regulation; provided, however, that any capital expenditure shall be amortized
(including interest on the amortized cost) over its useful life as determined in accordance with generally accepted accounting principles; (xiv) costs, fees, charges or assessments imposed by, or resulting from any mandate imposed on Landlord
by, any federal, state or local government for fire and police protection, trash removal, community services, or other services which do not constitute “Tax Expenses” as that term is defined in Section 4.2.8, below;
(xv) advertising, marketing and promotional expenditures incurred in connection with the Project, including, without limitation, costs of signs in, on or about the Project identifying or promoting the Project; and (xvi) payments under any
easement, license, operating agreement, declaration, restrictive covenant, or instrument pertaining to the sharing of costs by the Project or related to the use or operation of the Project. 
  
 Operating Expenses shall not include the following: (A) repairs,
restoration or other work occasioned by fire, wind, the elements or other casualty, to the extent covered by insurance proceeds received by Landlord, (B) income and franchise taxes of Landlord, (C) expenses incurred in leasing to or
procuring of tenants, leasing commissions, advertising expenses and expenses for the renovating of space leased to tenants; (D) costs of services or other benefits which are either not offered to Tenant or for which Tenant is charged directly,
but which are provided to other tenants of the Building without a separate charge, (E) cost of any item for which Landlord is entitled to receive or receives reimbursement (other than by virtue of a tenant paying its pro rata share of Operating
Expenses) by way of insurance proceeds, condemnation awards, warranty payments, or otherwise, (F) cost of correcting any defects in the original design or construction of the Building, (G) costs of general overhead and general
administrative expenses, not including management fees and building office expenses which are included in operating expenses by landlords of comparable buildings in the vicinity of the Building, (H) costs paid to any affiliates or other parties
related to Landlord for services or materials to the extent such costs are in excess of the amount that would be paid to an unrelated third party at market prices for such materials or services, (I) any amounts payable by Landlord as a result
of Landlord’s failure to perform its obligations on a timely basis including fines, penalties, late fees and overtime expenses, (J) costs incurred to comply with laws relating to hazardous materials, which was in existence in the Building
or the Project prior to the Lease Commencement Date, and was of such a nature that a federal, State or municipal governmental authority, if it had then had knowledge of the presence of such hazardous materials, in the state, and under the conditions
that it then existed in the Building or the Project, would have then required the removal of such hazardous materials or other remedial or containment action with respect thereto; and costs incurred to remove, remedy, contain, or treat hazardous
materials, which hazardous materials are brought into the Building or onto the Project after the date hereof by Landlord or any other tenant of the Building and is of such a nature, at that dine, that a federal, State or municipal governmental
authority, if it had then had knowledge of the presence of such hazardous materials, in the state, and under the conditions, that it then existed in the Building or the Project, 
  

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 would have then required the removal of such hazardous materials or other remedial or containment action with respect
thereto, (K) repairs, construction or any other costs necessary to remedy violations of laws in effect as of the date of this Lease and requiring compliance at any time during the Term of the Lease, (L) the wages and benefits of any
employee who does not devote substantially all of his or her employed time to the Building unless such wages and benefits are prorated to reflect time spent on operating and managing the Building vis-à-vis time spent on matters unrelated to
operating and managing the Building; provided, that in no event shall Operating Expenses for purposes of this Lease include wages and/or benefits attributable to personnel above the level of Project manager or Project engineer; and (M) any rent
payable with respect to the Building’s management office which is computed at rental rates in excess of fair market rents or payable with respect to space in excess of a reasonably sized management office taking into account the needs of the
Building. 
  
 If Landlord is not furnishing any particular work or
service (the cost of which, if performed by Landlord, would be included in Operating Expenses) to a tenant who has undertaken to perform such work or service in lieu of the performance thereof by Landlord, Operating Expenses shall be deemed to be
increased by an amount equal to the additional Operating Expenses which would reasonably have been incurred during such period by Landlord if it had at its own expense furnished such work or service to such tenant. If the Project is not at least one
hundred percent (100%) occupied during all or a portion of the Base Year or any Expense Year, Landlord shall elect to make an appropriate adjustment to the components of Operating Expenses for such year to determine the amount of Operating
Expenses that would have been incurred had the Project been one hundred percent (100%) occupied; and the amount so determined shall be deemed to have been the amount of Operating Expenses for such year. Operating Expenses for the Base Year
shall not include market-wide labor-rate increases due to extraordinary circumstances, including, but not limited to, boycotts and strikes, and utility rate increases due to extraordinary circumstances including, but not limited to, conservation
surcharges, boycotts, embargoes or other shortages, or amortized costs relating to capital improvements. In no event shall the components of Direct Expenses for any Expense Year related to electrical costs be less than the components of Direct
Expenses related to electrical costs in the Base Year. 
  
 4.2.8
Taxes. 
  
 4.2.8.1 “Tax Expenses” shall
mean all federal, state, county, or local governmental or municipal taxes, fees, charges or other impositions of every kind and nature, whether general, special, ordinary or extraordinary (including, without limitation, real estate taxes, general
and special assessments, transit taxes, business taxes, leasehold taxes or taxes based upon the receipt of rent, including gross receipts or sales taxes applicable to the receipt of rent, unless required to be paid by Tenant, personal property taxes
imposed upon the fixtures, machinery, equipment, apparatus, systems and equipment, appurtenances, furniture and other personal property used in connection with the Project, or any portion thereof), which shall be paid or accrued during any Expense
Year (without regard to any different fiscal year used by such governmental or municipal authority) because of or in connection with the ownership, leasing and operation of the Project, or any portion thereof. 
  

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 4.2.8.2 Tax Expenses shall include, without limitation: (i) Any tax on the rent, right to rent or
other income from the Project, or any portion thereof, or as against the business of leasing the Project, or any portion thereof; (ii) Any assessment, tax, fee, levy or charge in addition to, or in substitution, partially or totally, of any
assessment, tax, fee, levy or charge previously included within the definition of real property tax, it being acknowledged by Tenant and Landlord that Proposition 13 was adopted by the voters of the State of California in the June 1978 election
(“Proposition 13”) and that assessments, taxes, fees, levies and charges may be imposed by governmental agencies for such services as fire protection, street, sidewalk and road maintenance, refuse removal and for other governmental
services formerly provided without charge to property owners or occupants, and, in further recognition of the decrease in the level and quality of governmental services and amenities as a result of Proposition 13, Tax Expenses shall also include any
governmental or private assessments or the Project’s contribution towards a governmental or private cost-sharing agreement for the purpose of augmenting or improving the quality of services and amenities normally provided by governmental
agencies; (iii) Any assessment, tax, fee, levy, or charge allocable to or measured by the area of the Premises, the tenant improvements in the Premises, or the Rent payable hereunder, including, without limitation, any business or gross income
tax or excise tax with respect to the receipt of such rent, or upon or with respect to the possession, leasing, operating, management, maintenance, alteration, repair, use or occupancy by Tenant of the Premises, or any portion thereof; (iv) Any
assessment, tax, fee, levy or charge, upon this transaction or any document to which Tenant is a party, creating or transferring an interest or an estate in the Premises; and (v) All of the real estate taxes and assessments imposed upon or with
respect to the Building and all of the real estate taxes and assessments imposed on the land and improvements comprising the Project. 
  
 4.2.8.3 If Tax Expenses for any period during the Lease Term or any extension thereof are increased after payment thereof for any reason, including,
without limitation, error or reassessment by applicable governmental or municipal authorities, Tenant shall pay Landlord upon demand Tenant’s Share of any such increased Tax Expenses included by Landlord as Building Tax Expenses pursuant to the
terms of this Lease. Notwithstanding anything to the contrary contained in this Section 4.2.8 (except as set forth in Section 4.2.8.1, above), there shall be excluded from Tax Expenses (1) all excess profits taxes, franchise taxes,
gift taxes, capital stock taxes, inheritance and succession taxes, estate taxes, federal and state income taxes, and other taxes to the extent applicable to Landlord’s general or net income (as opposed to rents, receipts or income attributable
to operations at the Project), (ii) any items included as Operating Expenses, (iii) any items paid by Tenant under Section 4.5 of this Lease, and (iv) any real property transfer taxes applied to the Project, Building and
Premises. 
  
 4.2.8.4 Notwithstanding anything to the contrary
set forth in this Lease, the amount of Tax Expenses for the Base Year and any Expense Year shall be calculated without taking into account any decreases in real estate taxes obtained in connection with Proposition 8, and, therefore, the Tax Expenses
in the Base Year and/or an Expense Year may be greater than those actually incurred by Landlord, but shall, nonetheless, be the Tax Expenses due under this Lease; provided that (i) any costs and expenses incurred by Landlord in securing any
Proposition 8 reduction shall not be deducted from Tax Expenses nor included in Direct Expenses for purposes of this Lease, and (ii) tax refunds under Proposition 8 shall not be deducted from Tax Expenses nor refunded to Tenant, but rather
shall be the sole property of Landlord. Landlord and 
  

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 Tenant acknowledge that the preceding sentence is not intended to in any way affect (A) the inclusion in Tax
Expenses of the statutory two percent (2.0%) annual increase in Tax Expenses (as such statutory increase may be modified by subsequent legislation), or (B) the inclusion or exclusion of Tax Expenses pursuant to the terms of Proposition 13.
Notwithstanding the foregoing, upon a reassessment of the Building and/or the Project pursuant to the terms of Proposition 13 (a “Reassessment”) occurring after the Base Year which results in a decrease in Tax Expenses, the component of
Tax Expenses for the Base Year which is attributable to the assessed value of the Building and/or the Project under Proposition 13 prior to the Reassessment (without taking into account any Proposition 8 reductions) (the “Base Year Prop 13
Taxes”) shall be reduced, if at all, for the purposes of comparison to all subsequent Expense Years (commencing with the Expense Year in which the Reassessment takes place) to an amount equal to the real estate taxes based upon such
Reassessment, and if thereafter, in connection with a subsequent Reassessment, the assessed value of the Building and/or the Project under Proposition 13 shall increase, the current Base Year Prop 13 Taxes shall be increased for purposes of
comparison to all subsequent Expense Years (commencing with the Expense Year in which the Reassessment takes place) to an amount equal to the lesser of the original Base Year Prop 13 Taxes and an amount equal to the real estate taxes based upon such
Reassessment. 
  
 4.2.9 “Tenant’s Share” shall mean
the percentage set forth in Section 6 of the Summary. Tenant’s Share was calculated by multiplying the number of rentable square feet of the Premises, as set forth in Section 2.2 of the Summary, by 100, and dividing the product by the
total number of rentable square feet in the Building. If Tenant’s Share shall be adjusted in accordance with Section 1.2, above, at any time after the Base Year, then, as to the Expense Year in which such change occurs, Tenant’s Share
for such Expense Year shall be determined on the basis of the number of days during such Expense Year that each such Tenant’s Share was in effect. 
  
 4.3 Allocation of Direct Expenses. 
  
 4.3.1 Method of Allocation. The parties acknowledge that the Building is a part of a multi-building project and that the costs and expenses
incurred in connection with the Project (i.e., the Direct Expenses) should be shared between the tenants of the Building and the tenants of the other buildings in the Project. Accordingly, as set forth in Section 4.2 above, Direct Expenses
(which consists of Operating Expenses and Tax Expenses) are determined annually for the Project as a whole, and a portion of the Direct Expenses, which portion shall be reasonably determined by Landlord on an equitable basis, shall be allocated to
the tenants of the Building (as opposed to the tenants of any other buildings in the Project) and such portion shall be the Building Direct Expenses for purposes of this Lease. Such portion of Direct Expenses allocated to the tenants of the Building
shall include all Direct Expenses attributable solely to the Building and an equitable portion of the Direct Expenses attributable to the Project as a whole. 
  
 4.3.2 Cost Pools. Landlord shall have the right, from time to time, to equitably allocate some or all of the Direct Expenses for the Project
among different portions or occupants of the Project (the “Cost Pools”), in Landlord’s reasonable discretion. Such Cost Pools may include, but shall not be limited to, the office space tenants of a building of the Project or of the
Project, and the retail space tenants of a building of the Project or of the Project. The Direct Expenses allocable to each such Cost Pool shall be allocated to such Cost Pool and charged to the tenants within such Cost Pool in a reasonable and
equitable manner. 
  

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 4.4 Calculation and Payment of Additional Rent. If for any Expense Year ending or
commencing within the Lease Term, Tenant’s Share of Building Direct Expenses for such Expense Year exceeds Tenant’s Share of Building Direct Expenses applicable to the Base Year, then Tenant shall pay to Landlord, in the manner set forth
in Section 4.4.1, below; and as Additional Rent, an amount equal to the excess (the “Excess”). 
  
 4.4.1 Statement of Actual Building Direct Expenses and Payment by Tenant. Landlord shall give to Tenant following the end of each Expense
Year, a statement (the “Statement”) which shall state the Building Direct Expenses incurred or accrued for such preceding Expense Year, and which shall indicate the amount of the Excess. Upon receipt of the Statement for each Expense Year
commencing or ending during the Lease Term, if any excess is present, Tenant shall pay, with its next installment of Base Rent due or within thirty (30) days, whichever is earlier, the full amount of the Excess for such Expense Year, less the
amounts, if any, paid during such Expense Year as “Estimated Excess,” as that term is defined in Section 4.4.2, below. If the amounts paid by Tenant during an Expense Year as Estimated Excess exceed the Excess for such Expense Year,
then such difference shall be reimbursed by Landlord to Tenant within thirty (30) days following Tenant’s receipt of such Statement, provided that any Such reimbursement, at Landlord’s option, may be credited against the Additional
Rent next coming due under this Lease unless the Lease Term has expired, in which event Landlord shall refund the appropriate amount to Tenant. The failure of Landlord to timely furnish the Statement for any Expense Year shall not prejudice Landlord
or Tenant from enforcing its rights under this Article 4. Even though the Lease Term has expired and Tenant has vacated the Premises, when the final determination is made of Tenant’s Share of Building Direct Expenses for the Expense Year in
which this Lease terminates, if an Excess is present, Tenant shall immediately pay to Landlord such amount. The provisions of this Section 4.4.1 shall survive the expiration or earlier termination of the Lease Term. 
  
 4.4.2 Statement of Estimated Building Direct Expenses. In
addition, Landlord shall endeavor to give Tenant a yearly expense estimate statement (the “Estimate Statement”) which shall set forth Landlord’s reasonable estimate (the “Estimate”) of what the total amount of Building
Direct Expenses for the then-current Expense Year shall be and the estimated excess (the “Estimated Excess”) as calculated by comparing the Building Direct Expenses for such Expense Year, which shall be based upon the Estimate, to the
amount of Building Direct Expenses for the Base Year. The failure of Landlord to timely furnish the Estimate Statement for any Expense Year shall not preclude Landlord from enforcing its rights to collect any Estimated Excess under this Article 4,
nor shall Landlord be prohibited from revising any Estimate Statement or Estimated Excess theretofore delivered to the extent necessary. Thereafter, Tenant shall pay, with its next installment of Base Rent due, a fraction of the Estimated Excess for
the then-current Expense Year (reduced by any amounts paid pursuant to the last sentence of this Section 4.4.2). Such fraction shall have as its numerator the number of months which have elapsed in such current Expense Year, including the month
of such payment, and twelve (12) as its denominator. Until a new Estimate Statement is furnished (which Landlord shall have the right to deliver to Tenant at any time), Tenant shall pay monthly, with the monthly Base Rent installments, an
amount equal to one-twelfth (1/12) of the total Estimated Excess set forth in the previous Estimate Statement delivered by Landlord to Tenant. 
  

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 4.5 Taxes and Other Charges for Which Tenant Is Directly Responsible. 
  
 4.5.1 Tenant shall be liable for and shall pay thirty (30) days before
delinquency, taxes levied against Tenant’s equipment, furniture, fixtures and any other personal property located in or about the Premises. If any such taxes on Tenant’s equipment, furniture, fixtures and any other personal property are
levied against Landlord or Landlord’s property or if the assessed value of Landlord’s property is increased by the inclusion therein of a value placed upon such equipment, furniture, fixtures or any other personal property and if Landlord
pays the taxes based upon such increased assessment, which Landlord shall have the right to do regardless of the validity thereof but only under proper protest if requested by Tenant, Tenant shall upon demand repay to Landlord the taxes so levied
against Landlord or the proportion of such taxes resulting from such increase in the assessment, as the case may be. 
  
 4.5.2 If the tenant improvements in the Premises, whether installed and/or paid for by Landlord or Tenant and whether or not affixed to the real property
so as to become a part thereof, are assessed for real property tax purposes at a valuation higher than the valuation at which tenant improvements conforming to Landlord’s “building standard” in other space in the Building are
assessed, then the Tax Expenses levied against Landlord or the property by reason of such excess assessed valuation shall be deemed to be taxes levied against personal property of Tenant and shall be governed by the provisions of Section 4.5.1,
above. 
  
 4.5.3 Notwithstanding any contrary provision herein,
Tenant shall pay prior to delinquency any (i) rent tax or sales tax, service tax, transfer tax or value added tax, business tax or any other applicable tax on the rent or services herein or otherwise respecting this Lease, (ii) taxes
assessed upon or with respect to the possession, leasing, operation, management, maintenance, alteration, repair, use or occupancy by Tenant of the Premises or any portion of the Project, including the Project parking facility; or (iii) taxes
assessed upon this transaction or any document to which Tenant is a party creating or transferring an interest or an estate in the Premises. 
  
 ARTICLE 5 
  
 USE OF PREMISES 
  
 5.1 Permitted Use. Tenant shall use the Premises solely for the Permitted Use set forth in Section 7 of the Summary and Tenant shall
not use or permit the Premises or the Project to be used for any other purpose or purposes whatsoever without the prior written consent of Landlord, which may be withheld in Landlord’s sole discretion. 
  
 5.2 Prohibited Uses. Tenant further covenants and agrees that
Tenant shall not use, or suffer or permit any person or persons to use, the Premises or any part thereof for any use or purpose contrary to the provisions of the Rules and Regulations set forth in Exhibit D, attached hereto, or in violation of the
laws of the United States of America, the State of California, or the ordinances, regulations or requirements of the local municipal or county governing body or other 
  

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 lawful authorities having jurisdiction over the Project, including, without limitation, any such laws, ordinances,
regulations or requirements relating to hazardous materials or substances, as those terms are defined by applicable laws now or hereafter in effect. Tenant shall not do or permit anything to be done in or about the Premises which will in any way
damage the reputation of the Project or obstruct or interfere with the rights of other tenants or occupants of the Building, or injure or annoy them or use or allow the Premises to be used for any improper, unlawful or objectionable purpose, nor
shall Tenant cause, maintain or permit any nuisance in, on or about the Premises. Tenant shall comply with, and Tenant’s rights and obligations under the Lease and Tenant’s use of the Premises shall be subject and subordinate to, all
recorded easements, covenants, conditions, and restrictions now or hereafter affecting the Project. Tenant shall not cause or permit any “Hazardous Substance,” as that term is defined below, to be kept, maintained, used, stored, produced,
generated or disposed of (into the sewage or waste disposal system or otherwise) on or in the Premises by Tenant or Tenant’s agents, employees, contractors, invitees, assignees or sublessees, without first obtaining Landlord’s written
consent. Tenant shall immediately notify, and shall direct Tenant’s agents, employees contractors, invitees, assignees and sublessees to immediately notify, Landlord of any incident in, on or about the Premises, the Building or the Project that
would require the filing of a notice under any federal, state, local or quasi-governmental law (whether under common law, statute or otherwise), ordinance, decree, code, ruling, award, rule, regulation or guidance document now or hereafter enacted
or promulgated, as amended from time to time, in any way relating to or regulating any Hazardous Substance. As used herein, “Hazardous Substance” means any substance which is toxic, ignitable, reactive, or corrosive and which is regulated
by any local government, the State of California, or the United States government. “Hazardous Substance” includes any and all material or substances which are defined as “hazardous waste,” “extremely hazardous waste” or
a “hazardous substance” pursuant to state, federal or local governmental law. “Hazardous Substance” also includes asbestos, polychlorobiphenyls (i.e., PCB’s) and petroleum. 
  
 ARTICLE 6 
  
 SERVICES AND UTILITIES 
  
 6.1 Standard Tenant Services. Landlord shall provide the
following services on all days (unless otherwise stated below) during the Lease Term. 
  
 6.1.1 Subject to limitations imposed by all governmental rules, regulations and guidelines applicable thereto, Landlord shall provide heating, ventilation and air conditioning (“HVAC”) when necessary for
normal comfort for normal office use in the Premises from 7:00 AM to 6:00 P.M. Monday through Friday, and on Saturdays from 8:00 A.M. to 1:00 P.M. (collectively, the “Building Hours”), except for the date of observation of New Year’s
Day, Independence Day, Labor Day, Memorial Day, Thanksgiving Day, Christmas Day and, at Landlord’s discretion, other locally or nationally recognized holidays (collectively, the “Holidays”). Tenant shall cooperate fully with Landlord
at all times and abide by all regulations and requirements that Landlord may reasonably prescribe for the proper functioning and protection of the HVAC, electrical, mechanical and plumbing systems. 
  
 6.1.2 Landlord shall provide electricity to the Premises (including adequate
electrical wiring and facilities for connection to Tenant’s lighting fixtures and incidental use 
  

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 equipment) for lighting and power suitable for the Permitted Use as reasonably determined by Landlord, provided that
Tenant’s electrical usage shall be subject to applicable laws and regulations. Tenant shall bear the cost of replacement of lamps, starters and ballasts for non-Building standard lighting fixtures within the Premises. 
  
 6.1.3 Landlord shall provide city water from the regular Building outlets for
drinking, lavatory and toilet purposes in the Building Common Areas. 
  
 6.1.4 Landlord shall provide nonexclusive, non-attended automatic passenger elevator service during the Building Hours, shall have one elevator available at all other times, including on the Holidays, except in the event of emergency, and
shall provide nonexclusive, non-attended automatic passenger escalator service during Building Hours only. 
  
 6.1.5 Landlord shall provide nonexclusive freight elevator service subject to scheduling by Landlord. Landlord shall not charge for the use of any freight
elevator service. 
  
 6.1.6 Landlord shall provide customary
weekday janitorial services to the Premises, except the date of observation of the Holidays, in and about the Premises and customary occasional window washing services, each in a manner consistent with other Class “A” office buildings
located in the vicinity of the Project. 
  
 6.1.7 Tenant may, at
its own expense and subject to Landlord’s approval in its reasonable discretion, install its own security system (“Tenant’s Security System”) in the Premises; provided, however, that Tenant shall coordinate the installation and
operation of Tenant’s Security System with Landlord to assure that Tenant’s Security System is compatible with Landlord’s security system and the Building systems, and to the extent that Tenant’s Security System is not compatible
with Landlord’s security system and the Building systems, Tenant shall not be entitled to install or operate the Tenant’s Security System. Tenant shall be solely responsible, at Tenant’s sole cost and expense, for the monitoring,
operation and removal of Tenant’s Security System. 
  
 6.1.8
The company or companies Landlord Selects to provide services to the Building shall provide such services on a continuous and uninterrupted basis, competitively priced against other suppliers in the market, comparable in quality to suppliers of
services provided by landlords of comparable buildings in the vicinity of the Building. 
  
 6.2 Overstandard Tenant Use. Tenant shall not, without Landlord’s prior written consent, use heat-generating machines, machines other than normal fractional horsepower office machines, or equipment
or lighting other than Building standard lights in the Premises, which may affect the temperature otherwise maintained by the air conditioning system or increase the water normally furnished for the Premises by Landlord pursuant to the terms of
Section 6.1 of this Lease. If Tenant uses water, electricity, heat or air conditioning in excess of that supplied by Landlord pursuant to Section 6.1 of this Lease, Tenant shall pay to Landlord; upon billing, the cost of such excess
consumption, the cost of the installation, operation, and maintenance of equipment which is installed in order to supply such excess consumption, and the cost of the increased wear and tear on existing equipment caused by such excess consumption;
and Landlord may install devices to separately meter any increased use and in such event Tenant 
  

 -18- 

 shall pay the increased cost directly to Landlord, on demand, at the rates charged by the public utility company
furnishing the same, including the cost of such additional metering devices. Tenant’s use of electricity shall never exceed the capacity of the feeders to the Project or the risers or wiring installation. If Tenant desires to use heat,
ventilation or air conditioning during hours other than those for which Landlord is obligated to supply such utilities pursuant to the terms of Section 6.1 of this Lease, Tenant shall give Landlord such prior notice, if any, as Landlord shall
from time to time establish as appropriate, of Tenant’s desired use in order to supply such utilities, and Landlord shall supply such utilities to Tenant at such hourly cost to Tenant (which shall be treated as Additional Rent) as Landlord
shall from time to time establish. Landlord shall have the exclusive right, but not the obligation, to provide any additional services which may be required by Tenant, including, without limitation, locksmithing, lamp replacement, additional
janitorial service, and additional repairs and maintenance. If Tenant requests any such additional services, then Tenant shall pay to Landlord the cost of such additional services, including Landlord’s standard fee for its involvement with such
additional services, promptly upon being billed for same. 
  
 6.3
Interruption of Use. Tenant agrees that Landlord shall not be liable for damages, by abatement of Rent or otherwise, for failure to furnish or delay in furnishing any service (including telephone and telecommunication services), or for
any diminution in the quality or quantity thereof, when such failure or delay or diminution is occasioned, in whole or in part, by breakage, repairs, replacements, or improvements, by any strike, lockout or other labor trouble, by inability to
secure electricity, gas, water, or other fuel at the Building or Project after reasonable effort to do so, by any riot or other dangerous condition, emergency, accident or casualty whatsoever, by act or default of Tenant or other parties, or by any
other cause beyond Landlord’s reasonable control; and such failures or delays or diminution shall never be deemed to constitute an eviction or disturbance of Tenant’s use and possession of the Premises or relieve Tenant from paying Rent or
performing any of its obligations under this Lease. Furthermore, Landlord shall not be liable under any circumstances for a loss of, or injury to, property or for injury to, or interference with, Tenant’s business, including, without
limitation, loss of profits, however occurring, through or in connection with or incidental, to a failure to furnish any of the services or utilities as set forth in this Article 6. 
  
 ARTICLE 7 
  
 REPAIRS 
  
 Tenant shall, at Tenant’s own expense, keep the Premises, including all improvements, fixtures and furnishings therein, and the floor or floors of
the Building on which the Premises are located, in good order, repair and condition at all times during the Lease Term. In addition, Tenant shall, at Tenant’s own expense, but under the supervision and subject to the prior approval of Landlord,
and within any reasonable period of time specified by Landlord, promptly and adequately repair all damage to the Premises and replace or repair all damaged, broken, or worn fixtures and appurtenances, except for damage caused by ordinary wear and
tear or beyond the reasonable control of Tenant; provided however, that, Landlord shall have the exclusive right, at Landlord’s option, but not the obligation, to make such repairs and replacements, and Tenant shall pay to Landlord the cost
thereof, including Landlord’s standard commercially reasonable fee for its involvement with such repairs and replacements, promptly upon being 
  

 -19- 

 billed for same. Landlord may, but shall not be required to, enter the Premises at all reasonable times to make such
repairs, alterations, improvements or additions to the Premises or to the Project or to any equipment located in the Project as Landlord shall desire or deem necessary or as Landlord may be required to do by governmental or quasi-governmental
authority or court order or decree. Tenant hereby waives any and all rights under and benefits of subsection 1 of Section 1932 and Sections 1941 and 1942 of the California Civil Code or under any similar law, statute, or ordinance now or
hereafter in effect. 
  
 ARTICLE 8 
  
 ADDITIONS AND ALTERATIONS 
  
 8.1 Landlord’s Consent to Alterations. Tenant may not make
or suffer to be made any improvements, alterations, additions or changes to the Premises or any mechanical, plumbing or HVAC facilities or systems pertaining to the Premises (collectively, the “Alterations”) without first procuring the
prior written consent of Landlord to such Alterations, which consent shall be requested by Tenant in accordance with the terms and conditions of this Article 8, and which consent shall not be unreasonably withheld, conditioned or delayed by
Landlord, provided that (i) it shall be deemed reasonable for Landlord to withhold its consent to any Alteration which adversely affects the structural portions or the systems or equipment of the Building or is visible from the exterior of the
Building, and (ii) Tenant shall be permitted to make Alterations following ten (10) business days notice to Landlord, but without Landlord’s consent, to the extent that such Alterations are cosmetic in nature and do not
(i) involve the expenditure of more than $5,000.00 in the aggregate per Alteration, nor (ii) affect the exterior appearance of the Building, the structural portions of the Building, or the systems and equipment in the Building. Landlord
may impose, as a condition of its consent to any and all Alterations or repairs of the Premises or about the Premises, such requirements as Landlord in its sole discretion may deem desirable. 
  
 8.2 Manner of Construction. Landlord shall have the exclusive
right, at Landlord’s option, but not the obligation, to make the Alterations at Tenant’s sole cost and expense. Prior to the commencement of construction of any Alterations or repairs, Tenant shall submit to Landlord, for Landlord’s
review and approval in its reasonable discretion, all plans, specifications and working drawings relating thereto. Tenant, at its sole cost and expense, shall retain an architect/space planner selected by Tenant, and reasonably approved by Landlord,
to prepare such plans, specifications and working drawings; provided that, Tenant shall also retain the engineering consultants designated by Landlord to prepare all plans and engineering working drawings, if any, relating to the structural,
mechanical, electrical, plumbing, HVAC, lifesafety and sprinkler work of the Alterations. Tenant shall cause each architect/space planner and engineer retained by Tenant to follow Landlord’s standard construction administration procedures and
to utilize the standard specifications and details for the Building, all as promulgated by Landlord from time to time. Tenant and Tenant’s architect/space planner shall verify, in the field, the dimensions and conditions as shown on the
relevant portions of the “Base Building” plans, and Tenant and Tenant’s architect/space planner shall be solely responsible for the same, and Landlord shall have no responsibility in connection therewith. Landlord’s review of
plans, specifications and working drawings as set forth in this Section 8.2, shall be for its sole purpose and shall not imply Landlord’s review of the same, or obligate Landlord to review the 
  

 -20- 

 same, for quality, design, compliance with applicable building codes or other like matters. Accordingly, notwithstanding
that any plans, specifications or working drawings are reviewed by Landlord or its space planner, architect, engineers and consultants, and notwithstanding any advice or assistance which may be rendered to Tenant by Landlord or Landlord’s space
planner, architect, engineers, and consultants, Landlord shall have no liability whatsoever in connection therewith and shall not be responsible for any omissions or errors contained in the plans, specifications and working drawings for the
Alterations, and Tenant’s waiver and indemnity set forth in Section 10.1 of this Lease, below, shall specifically apply to the plans, specifications, and working drawings for the Alterations. Following Landlord’s approval in its
reasonable discretion of all plans, specifications and working drawings for the Alterations, a contractor to construct the Alterations shall be selected by Tenant from the list of contractors approved by Landlord or, at Tenant’s option,
exercisable by written notice to Landlord, pursuant to a competitive bidding process. If Tenant shall select a contractor from Landlord’s list of approved contractors, then Landlord shall provide to Tenant an itemized statement of costs, as set
forth in the proposed contract with such contractor. If Tenant shall elect to have a contractor selected by a competitive bidding process, then (i) Landlord shall solicit bids for construction of the Alterations from three (3) qualified,
licensed and reputable contractors selected by Landlord (each of which contractors shall be notified in the bidding package of the requirement that, unless Landlord otherwise requires, the selected contractor shall use the fire, life safety
subcontractor designated by Landlord), (ii) Landlord shall perform a reconciliation of the submitted bids to adjust for inconsistent or incorrect assumptions so that a like kind comparison can be made and a low bid determined, and
(iii) Landlord shall provide to Tenant an itemized statement of costs, as set forth in the proposed contract with the contractor who submits the lowest bid. Tenant shall approve and deliver to Landlord the itemized statement of costs provided
to Tenant in accordance with this Section 8.2, and upon receipt of such itemized statement of costs by Landlord, Landlord shall be released by Tenant (i) to retain the contractor who submitted such itemized statement of costs, and
(ii) to purchase the items set forth in such itemized statement of costs and to commence the construction relating to such items. Landlord hereby assigns to Tenant all warranties and guaranties by the contractor selected in accordance with this
Section 8.2 to construct the Alterations, and Tenant hereby waives all claims against Landlord relating to, or arising out of the construction of, the Alterations. In the event Tenant requests any Alterations in the Premises which require or
give rise to governmentally required changes to the “Base Building,” as that term is defined below, then Landlord shall, at Tenant’s expense, make such changes to the Base Building. As used in this Lease, the “Base Building”
shall include the structural portions of the Building, and the public restrooms, elevators, exit stairwells and the systems and equipment located in the internal core of the Building on the floor or floors on which the Premises are located. In
addition to Tenant’s obligations under Article 9 of this Lease, upon completion of any Alterations, Tenant agrees to cause a Notice of Completion to be recorded in the office of the Recorder of the County in which the Project is located in
accordance with Section 3093 of the Civil Code of the State of California or any successor statute, and Tenant shall deliver to the Project construction manager a reproducible copy of the “as built” drawings of the Alterations as well
as all permits, approvals and other documents issued by any governmental agency in connection with the Alterations. 
  
 8.3 Payment for Improvements. Tenant shall pay to Landlord, within ten (10) days after being billed for the same, all costs related to
the construction of the Alterations, including, without limitation, the following items and costs: (i) all amounts actually paid by Landlord to 
  

 -21- 

 any architect/space planner, engineer, consultant, contractor, subcontractor, mechanic, materialman or other person,
whether retained by Landlord or Tenant, in connection with the Alterations, and all fees incurred by, and the actual cost of documents and materials supplied by, Landlord and Landlord’s consultants in connection with the preparation and review
of all plans, specifications and working drawings for the Alterations; (ii) all plan check, permit and license fees relating to construction of the Alterations paid by Landlord; (iii) the cost of any changes in the Base Building when such
changes are required by any plans, specifications or working drawings for the Alterations (including if such changes are due to the fact that such work is prepared on an unoccupied basis), such cost to include all direct architectural and/or
engineering fees and expenses incurred by Landlord in connection therewith; (iv) the cost of any changes to the plans, specifications and working drawings for the Alterations or to the Alterations themselves required by all applicable zoning
and building codes and other laws and paid by Landlord; (v) sales and use taxes and Title 24 fees imposed on, assessed against or paid by Landlord; (vi) Landlord’s standard fee for its involvement with such Alterations; and
(vii) all other costs incurred by Landlord in connection with the construction of the Alterations. Landlord, at its option, may render bills to Tenant in advance of, or during, construction of the Alterations so as to enable Landlord to pay all
costs and expenses incurred by Landlord in connection with the Alterations (including, without limitation, costs of the contractor retained to construct the Alterations) without advancing Landlord’s own funds. At Landlord’s election in its
sole and absolute discretion, Tenant shall deliver to Landlord prior to commencement of construction of the Alterations cash in an amount equal to all estimated costs related to the construction of such Alterations, or such lesser amount as Landlord
shall specify, to be held by Landlord and disbursed by Landlord for costs related to the construction of the Alterations as such costs are incurred. In the event that, after Tenant’s approval of a cost proposal for the Alterations in accordance
with Section 8.2, above, any revisions, changes or substitutions shall be made to the plans, specifications and working drawings or the Alterations, any additional costs which arise in connection with such revisions, changes or substitutions or
any other additional costs shall be paid by Tenant to Landlord immediately upon Landlord’s request. Any surplus funds delivered by Tenant and held by Landlord in connection with the Alterations shall be refunded to Tenant when the all costs
related to the construction of the Alterations have been paid in full. 
  
 8.4 Construction Insurance. In addition to the requirements of Article 10 of this Lease; in the event that any Alterations are made pursuant to this Article 8, prior to the commencement of such Alterations, Tenant shall
provide Landlord with evidence that Tenant carries “Builder’s All Risk” insurance in an amount approved by Landlord covering the construction of such Alterations, and such other insurance as Landlord may require, it being understood
and agreed that all of such Alterations shall be insured by Tenant pursuant to Article 10 of this Lease immediately upon completion thereof. In addition, Landlord may, in its discretion, require Tenant to obtain a lien and completion bond or some
alternate form of security satisfactory to Landlord in an amount sufficient to ensure the lien-free completion of such Alterations and naming Landlord as a co-obligee. 
  
 8.5 Landlord’s Property. All Alterations, improvements, fixtures, equipment and/or appurtenances (other
than Tenant’s trade fixtures and personal property) which may be installed or placed in or about the Premises, from time to time, shall be at the sole cost of Tenant and shall be and become the property of Landlord; provided, however, Landlord
may, by written notice to 
  

 -22- 

 Tenant prior to the end of the Lease Term, or given following any earlier termination of this Lease, require Tenant, at
Tenant’s expense, to remove any Alterations or improvements and to repair any damage to the Premises and Building caused by such removal and return the affected portion of the Premises to their condition existing prior to the installment of
such Alterations or improvements or, at Landlord’s election, to a building standard tenant improved condition as determined by Landlord; provided; however, that notwithstanding the foregoing, upon request by Tenant at the time of Tenant’s
request for Landlord’s consent to any Alteration or improvement, Landlord shall notify Tenant whether the applicable Alteration or improvement will be required to be removed pursuant to the terms of this Section 8.5. If Tenant fails to
complete such removal and/or to repair any damage caused by the removal of any Alterations or improvements in the Premises and return the affected portion of the Premises to their condition existing prior to the installment of such Alterations or
improvements or, if elected by Landlord, to a building standard tenant improved condition as determined by Landlord, prior to the expiration or earlier termination of this Lease, then Rent shall continue to accrue under this Lease in accordance with
Article 16, below, after the end of the Lease Term until such work shall be completed, and Landlord shall have the right, but not the obligation, to perform such work and to charge the cost thereof to Tenant. Tenant hereby protects, defends,
indemnifies and holds Landlord harmless from any liability, cost, obligation, expense or claim of lien in any manner relating to the installation, placement, removal or financing of any such Alterations, improvements, fixtures and/or equipment in,
on or about the Premises, which obligations of Tenant shall survive the expiration or earlier termination of this Lease. 
  
 ARTICLE 9 
  
 COVENANT AGAINST LIENS, 
  
 Tenant shall keep the Project and Premises free from any liens or encumbrances arising out of the work performed, materials furnished or obligations
incurred by or on behalf of Tenant, and shall protect, defend, indemnify and hold Landlord harmless from and against any claims, liabilities, judgments or costs (including, without limitation, reasonable attorneys’ fees and costs) arising out
of same or in connection therewith. Tenant shall give Landlord notice at least twenty (20) days prior to the commencement of any such work on the Premises (or such additional time as may be necessary under applicable laws) to afford Landlord
the opportunity of posting and recording appropriate notices of non-responsibility. Tenant shall remove any such lien or encumbrance by bond or otherwise within five (5) business days after notice by Landlord, and if Tenant shall fail to do so,
Landlord may pay the amount necessary to remove such lien or encumbrance, without being responsible for investigating the validity thereof. The amount so paid shall be deemed Additional Rent under this Lease payable upon demand, without limitation
as to other remedies available to Landlord under this Lease. Nothing contained in this Lease shall authorize Tenant to do any act which shall subject Landlord’s title to the Building or lo any liens or encumbrances whether claimed by operation
of law or express or implied contract. Any claim to a lien or encumbrance upon the Building or Premises arising in connection with any such work or respecting the Premises not performed by or at the request of Landlord shall be null and void, or at
Landlord’s option shall attach only against Tenant’s interest in the Premises and shall in all respects be subordinate to Landlord’s title to the Project, Building and Premises. 
  

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 ARTICLE 10 
  
 INSURANCE 
  
 10.1 Indemnification and Waiver. Tenant hereby assumes all risk of damage to property or injury to persons in, upon or about the Premises
from any cause whatsoever (including, but not limited to, any personal injuries resulting from a slip and fall in, upon or about the Premises) and agrees that other than to the extent caused by Landlord’s gross negligence or willful misconduct,
Landlord, its partners, subpartners and their respective officers, agents, servants, employees, and independent contractors (collectively, “Landlord Parties”) shall not be liable for, and are hereby released from any responsibility for,
any damage either to person or property or resulting from the loss of use thereof, which damage is sustained by any person in, upon or about the Premises or by Tenant or by other persons claiming through Tenant in, upon or about the Project,
including, without limitation, the Project parking facility. Tenant promptly upon notice shall indemnify, defend, protect, and hold harmless the Landlord Parties from any and all loss, cost, damage, expense and liability (including without
limitation court costs and reasonable attorneys’ fees) incurred in connection with or arising from any cause in, on or about the Premises (including, but not limited to, a slip and fall), any acts, omissions or negligence of Tenant or of any
person claiming by, through or under Tenant, or of the contractors, agents, servants, employees, invitees, guests or licensees of Tenant or any such person, in, on or about the Project or any breach of the terms of this Lease, either prior to,
during, or after the expiration of the Lease Term, provided that the terms of the foregoing indemnity shall not apply to the negligence or willful misconduct of Landlord. Should Landlord be named as a defendant in any suit brought against Tenant in
connection with or arising out of Tenant’s occupancy of the Premises, Tenant shall pay to Landlord its costs and expenses incurred in such suit, including without limitation, its actual professional fees such as reasonable appraisers’,
accountants’ and attorneys’ fees. The provisions of this Section 10.1 shall survive the expiration or sooner termination of this Lease with respect to any claims or liability arising in connection with any event occurring prior to
such expiration or termination. 
  
 10.2 Tenant’s
Compliance With Landlord’s Fire and Casualty Insurance. Tenant shall, at Tenant’s expense, comply with all insurance company requirements pertaining to the use of the Premises. Tenant shall not cause or permit anything to be done
in, upon or about the Premises which would in any way increase the premium for, cause the cancellation of or otherwise affect any insurance carried by Landlord in connection with the Project or any part thereof, or cause a cancellation of any
insurance policy covering the Building or any part thereof. Without limiting Landlord’s remedies for Tenant’s breach of the foregoing covenant, if Tenant’s conduct or use of the Premises causes any increase in the premium for such
insurance policies then Tenant shall reimburse Landlord for any such increase promptly upon being billed therefor. Tenant, at Tenant’s expense, shall comply with all rules, orders, regulations or requirements of the American Insurance
Association (formerly the National Board of Fire Underwriters) and any similar body. 
  
 10.3 Tenant’s Insurance. Tenant shall maintain the following coverages in the following amounts. 
  

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 10.3.1 Commercial General Liability Insurance covering the insured against claims of bodily injury,
personal injury and property damage (including loss of use thereof) arising out of Tenant’s operations, and contractual liabilities (covering the performance by Tenant of its indemnity agreements) including a Broad Form endorsement covering the
insuring provisions of this Lease and the performance by Tenant of the indemnity agreements set forth in Section 10.1 of this Lease, for limits of liability not less than: 
  

			
	Bodily Injury and Property Damage Liability	  	 $2,000,000 each occurrence
 $4,000,000 annual
aggregate

		
	Personal Injury Liability	  	 $2,000,000 each occurrence
 $4,000,000 annual
aggregate
 0% Insured’s participation

  
 10.3.2 Physical Damage
Insurance covering (i) all office furniture, business and trade fixtures, office equipment, free-standing cabinet work, movable partitions, merchandise and all other items of Tenant’s property on the Premises installed by, for, or at the
expense of Tenant, (ii) any improvements which exist in the Premises as of the Lease Commencement Date (excluding the Base Building) (the “Original Improvements”), and (iii) all other improvements, alterations and additions to
the Premises (collectively, the “Tenant Improvements”). Such insurance shall be written on an “all risks” of physical loss or damage basis, for the full replacement cost value (subject to reasonable deductible amounts) new
without deduction for depreciation of the covered items and in amounts that meet any co-insurance clauses of the policies of insurance and shall include coverage for damage or other loss caused by fire or other peril including, but not limited to,
vandalism and malicious mischief, theft, water damage of any type, including sprinkler leakage, bursting or stoppage of pipes, and explosion, and providing business interruption coverage for a period of one year. 
  
 10.3.3 Worker’s Compensation and Employer’s Liability or other
similar insurance pursuant to all applicable state and local statutes and regulations. 
  
 10.4 Form of Policies. The minimum limits of policies of insurance required of Tenant under this Lease shall in no event limit the liability of Tenant under this Lease. Such insurance shall (i) name
Landlord, and any other party the Landlord so specifies, as an additional insured, including Landlord’s managing agent, if any; (ii) specifically cover the liability assumed by Tenant under this Lease, including, but not limited to,
Tenant’s obligations under Section 10.1 of this Lease; (iii) be issued by an insurance company having a rating of not less than A-VIII in Best’s Insurance Guide or which is otherwise reasonably acceptable to Landlord and licensed
to do business in the State of California; (iv) be primary insurance as to all claims thereunder and provide that any insurance carried by Landlord is excess and is non-contributing with any insurance requirement of Tenant; (v) be in form
and content reasonably acceptable to Landlord; and (vi) provide that said insurance shall not be canceled or coverage changed unless thirty (30) days’ prior written notice shall have been given to Landlord and any mortgagee of
Landlord. Tenant shall deliver said policy or policies or certificates thereof to Landlord on or before the Lease Commencement Date and at least thirty (30) days before the expiration dates thereof. In the event Tenant shall fail to procure
such insurance, or to deliver such policies or certificates, Landlord may, at its option, procure such policies for the account of Tenant, and the cost thereof shall be paid to Landlord within five (5) days after delivery to Tenant of bills
therefor. 
  

 -25- 

 10.5 Subrogation. Landlord and Tenant intend that their respective property loss risks
shall be borne by reasonable insurance carriers to the extent above provided, and Landlord and Tenant hereby agree to look solely to, and seek recovery only from, their respective insurance carriers in the event of a property loss to the extent that
such coverage is agreed to be provided hereunder. The parties each hereby waive all rights and claims against each other for such losses, and waive all rights of subrogation of their respective insurers, provided such waiver of subrogation shall not
affect the right to the insured to recover thereunder. The parties agree that their respective insurance policies are now, or shall be, endorsed such that the waiver of subrogation shall not affect the right of the insured to recover thereunder, so
long as no material additional premium is charged therefor. 
  
 10.6 Additional Insurance Obligations. Tenant shall carry and maintain during the entire Lease Term, at Tenant’s sole cost and expense, increased amounts of the insurance required to be carried by Tenant pursuant to this
Article 10 and such other reasonable types of insurance coverage and in such reasonable amounts covering the Premises and Tenant’s operations therein, as may be reasonably requested by Landlord; provided that in no event shall such new or
increased amounts or types of insurance exceed that required of comparable tenants by landlords of comparable buildings in the vicinity of the Building. 
  
 ARTICLE 11 
  
 DAMAGE AND DESTRUCTION 
  
 11.1 Repair of Damage to Premises by Landlord. Tenant shall promptly notify Landlord of any damage to the Premises resulting from fire or
any other casualty. If the Premises or any Common Areas necessary to Tenant’s use of or access to the Premises shall be damaged by fire or other casualty, Landlord shall promptly and diligently, subject to reasonable delays for insurance
adjustment or other matters beyond Landlord’s reasonable control, and subject to all other terms of this Article 11, restore the Base Building and such Common Areas. Such restoration shall be to substantially the same condition of the Base
Building and the Common Areas prior to the casualty, except for modifications required by zoning and building codes and other laws or by the holder of a mortgage on the Building or Project or any other modifications to the Common Areas deemed
desirable by Landlord, provided that access to the Premises and any common restrooms serving the Premises shall not be materially impaired. Upon the occurrence of any damage to the Premises, upon notice (the “Landlord Repair Notice”) to
Tenant, from Landlord, Tenant shall assign to Landlord (or to any party designated by Landlord) all insurance proceeds payable to Tenant under Tenant’s insurance required under items (ii) and (iii) of Section 10.3 of this Lease,
and Landlord shall repair any injury or damage to the Tenant Improvements and the Original Improvements installed in the Premises and shall return such Tenant Improvements and Original Improvements to their original condition; provided that if the
cost of such repair by Landlord exceeds the amount of insurance proceeds received by Landlord from Tenant’s insurance carrier, as assigned by Tenant, the cost of such repairs shall be paid by Tenant to Landlord prior to Landlord’s
commencement of repair of the damage. In the event that Landlord does not deliver the Landlord Repair Notice within sixty 
  

 -26- 

 (60) days following the date the casualty becomes known to Landlord, Tenant shall, at its sole cost and expense, repair
any injury or damage to the Tenant Improvements and the Original Improvements installed in the Premises and shall return such Tenant Improvements and Original Improvements to their original condition. Whether or not Landlord delivers a Landlord
Repair Notice, prior to the commencement of construction, Tenant shall submit to Landlord, for Landlord’s review and approval, all plans, specifications and working drawings relating thereto, and Landlord shall select the contractors to perform
such improvement work. Landlord shall not be liable for any inconvenience or annoyance to Tenant or its visitors, or injury to Tenant’s business resulting in any way from such damage or the repair thereof; provided, however, if such fire or
other casualty shall have damaged the Premises or a portion thereof or Common Areas necessary to Tenant’s occupancy, then Landlord shall allow Tenant a proportionate abatement of Rent during the time and to the extent and in the proportion that
the Premises or such portion thereof are unfit for occupancy for the purposes permitted under this Lease, and are not occupied by Tenant as a result thereof; provided, however, if the damage or destruction is due to the negligence or willful
misconduct of Tenant or any of its agents, employees, contractors, invitees or guests, then Tenant shall be responsible for any reasonable, applicable insurance deductible (which shall be payable to Landlord upon demand). In the event that Landlord
shall not deliver the Landlord Repair Notice, Tenant’s right to rent abatement pursuant to the preceding sentence shall terminate as of the date which is reasonably determined by Landlord to be the date Tenant should have completed repairs to
the Premises assuming Tenant used reasonable due diligence in connection therewith. 
  
 11.2 Landlord’s Option to Repair. Notwithstanding the terms of Section 11.1 of this Lease, Landlord may elect not to rebuild and/or restore the Premises, Building and/or Project, and instead
terminate this Lease, by notifying Tenant in writing of such termination within sixty (60) days after the date of discovery of the damage, such notice to include a termination date giving Tenant sixty (60) days to vacate the Premises, but
Landlord may so elect only if the Building or Project shall be damaged by fire or other casualty or cause, whether or not the Premises are affected, and one or more of the following conditions is present: (i) in Landlord’s architect’s
reasonable judgment, repairs cannot reasonably be completed within one hundred eighty (180) days after the date of discovery of the damage (when such repairs are made without the payment of overtime or other premiums); (ii) the holder of
any mortgage on the Building or Project or ground lessor with respect to the Building or Project shall require that the insurance proceeds or any portion thereof be used to retire the mortgage debt, or shall terminate the ground lease, as the case
may be; (iii) the damage is not fully covered by Landlord’s insurance policies or that portion of the proceeds from Landlord’s insurance policies allocable to the Building or the Project, as the case may be; (iv) other than where
Tenant has already extended the Lease Term pursuant to the terms of Section 1.3 of this Lease, the damage occurs during the last twelve (12) months of the Lease Term; or (vi) any owner of any other portion of the Project, other than
Landlord, does not intend to repair the damage to such portion of the Project. In the event this Lease is terminated in accordance with the terms of this Section 11.2, Tenant shall assign to Landlord (or to any party designated by Landlord) all
insurance proceeds payable to Tenant under Tenant’s insurance required under items (ii) and (iii) of Section 10.3 of this Lease. 
  
 11.3 Waiver of Statutory Provisions. The provisions of this Lease, including this Article 11, constitute an express agreement between
Landlord and Tenant with respect to any and all damage to, or destruction of, all or any part of the Premises, the Building or the Project, 
  

 -27- 

 and any statute or regulation of the State of California, including, without limitation, Sections 1932(2) and 1933(4) of
the California Civil Code, with respect to any rights or obligations concerning damage or destruction in the absence of an express agreement between the parties, and any other statute or regulation, now or hereafter in effect, shall have no
application to this Lease or any damage or destruction to all or any part of the Premises, the Building or the Project. 
  
 ARTICLE 12 
  
 NONWAIVER 
  
 No provision of this Lease shall be deemed waived by either party hereto unless expressly waived in a writing signed thereby. The waiver by either party
hereto of any breach of any term, covenant or condition herein contained shall not be deemed to be a waiver of any subsequent breach of same or any other term, covenant or condition herein contained. The subsequent acceptance of Rent hereunder by
Landlord shall not be deemed to be a waiver of any preceding breach by Tenant of any term, covenant or condition of this Lease, other than the failure of Tenant to pay the particular Rent so accepted, regardless of Landlord’s knowledge of such
preceding breach at the time of acceptance of such Rent. No acceptance of a lesser amount than the Rent herein stipulated shall be deemed a waiver of Landlord’s right to receive the full amount due, nor shall any endorsement or statement on any
check or payment or any letter accompanying such check or payment be deemed an accord and satisfaction, and Landlord may accept such check or payment without prejudice to Landlord’s right to recover the full amount due. No receipt of monies by
Landlord from Tenant after the termination of this Lease shall in any way alter the length of the Lease Term or of Tenant’s right of possession hereunder, or after the giving of any notice shall reinstate, continue or extend the Lease Term or
affect any notice given Tenant prior to the receipt of such monies, it being agreed that after the service of notice or the commencement of a suit, or after final judgment for possession of the Premises; Landlord may receive and collect any Rent
due, and the payment of said Rent shall not waive or affect said notice, suit or judgment. 
  
 ARTICLE 13 
  
 CONDEMNATION 
  
 If the whole or any part
of the Premises, Building or Project shall be taken by power of eminent domain or condemned by any competent authority for any public or quasi-public use or purpose, or if any adjacent property or street shall be so taken or condemned, or
reconfigured or vacated by such authority in such manner as to require the use, reconstruction or remodeling of any part of the Premises, Building or Project, or if Landlord shall grant a deed or other instrument in lieu of such taking by eminent
domain or condemnation, Landlord shall have the option to terminate this Lease effective as of the date possession is required to be surrendered to the authority. If more than twenty-five percent (25%) of the rentable square feet of the
Premises is taken, or if all reasonable access to the Premises is substantially impaired, in each case for a period in excess of one hundred eighty (180) days, Tenant shall have the option to terminate this Lease effective as of the date
possession is required to be surrendered to the authority. Tenant shall not because of such taking assert any claim against Landlord or the authority for any compensation because of such taking and Landlord shall be entitled to the entire award or

  

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 payment in connection therewith, except that Tenant shall have the right to file any separate claim available to Tenant
for any taking of Tenant’s personal property and fixtures belonging to Tenant and removable by Tenant upon expiration of the Lease Term pursuant to the terms of this Lease, and for moving expenses, so long as such claims do not diminish the
award available to Landlord, its ground lessor with respect to the Building or Project or its mortgagee, and such claim is payable separately to Tenant. All Rent shall be apportioned as of the date of such termination. If any part of the Premises
shall be taken, and this Lease shall not be so terminated, the Rent shall be proportionately abated. Tenant hereby waives any and all rights it might otherwise have pursuant to Section 1265.130 of The California Code of Civil Procedure.
Notwithstanding anything to the contrary contained in this Article 13, in the event of a temporary taking of all or any portion of the Premises for a period of one hundred and eighty (180) days or less, then this Lease shall not terminate but
the Base Rent and the Additional Rent shall be abated for the period of such taking in proportion to the ratio that the amount of rentable square feet of the Premises taken bears to the total rentable square feet of the Premises. Landlord shall be
entitled to receive the entire award made in connection with any such temporary taking. 
  
 ARTICLE 14 
  
 ASSIGNMENT AND SUBLETTING 
  
 14.1
Transfers. Tenant shall not, without the prior written consent of Landlord, which consent shall not be unreasonably withheld, conditioned or delayed, assign, mortgage, pledge, hypothecate, encumber, or permit any lien to attach to, or
otherwise transfer, this Lease or any interest hereunder, permit any assignment, or other transfer of this Lease or any interest hereunder by operation of law, sublet the Premises or any part thereof, or enter into any license or concession
agreements or otherwise permit the occupancy or use of the Premises or any part thereof by any persons other than Tenant and its employees and contractors (all of the foregoing are hereinafter sometimes referred to individually as a
“Transfer,” and, collectively, as “Transfers” and any person to whom any Transfer is made or sought to be made is hereinafter sometimes referred to as a “Transferee”). If Tenant desires Landlord’s consent to any
Transfer, Tenant shall notify Landlord in writing, which notice (the “Transfer Notice”) shall include (i) the proposed effective date of the Transfer, which shall not be less than thirty (30) days nor more than one hundred eighty
(180) days after the date of delivery of the Transfer Notice, (ii) a description of the portion of the Premises to be transferred (the “Subject Space”), (iii) all of the terms of the proposed Transfer and the consideration
therefor, including calculation of the “Transfer Premium”, as that term is defined in Section 14.3 below, in connection with such Transfer, the name and address of the proposed Transferee, and a copy of all existing executed and/or
proposed documentation pertaining to the proposed Transfer, including all existing operative documents to be executed to evidence such Transfer or the agreements incidental or related to such Transfer, and (iv) current financial statements of
the proposed Transferee certified by an officer, partner or owner thereof, business credit and personal references and history of the proposed Transferee and any other information reasonably required by Landlord which will enable Landlord to
determine the financial responsibility, character, and reputation of the proposed Transferee, nature of such Transferee’s business and proposed use of the Subject Space. Any Transfer made without Landlord’s prior written consent shall, at
Landlord’s option, be null, void and of no effect, and shall, at Landlord’s option, constitute a default by Tenant under this Lease. Whether or not Landlord consents to any proposed Transfer, Tenant shall pay Landlord’s 
  

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 reasonable review and processing fees, as well as any reasonable professional fees (including, without limitation,
attorneys’, accountants’, architects’, engineers’ and consultants’ fees) incurred by Landlord, within thirty (30) days after written request by Landlord. 
  
 14.2 Landlord’s Consent. Landlord shall not unreasonably withhold, condition or delay its consent to any
proposed Transfer of the Subject Space to the Transferee on the terms specified in the Transfer Notice. Without limitation as to other reasonable grounds for withholding consent, the parties hereby agree that it shall be reasonable under this Lease
and under any applicable law for Landlord to withhold consent to any proposed Transfer where one or more of the following apply: 
  
 14.2.1 The Transferee is of a character or reputation or engaged in a business which is not consistent with the quality of the Building or the Project;

  
 14.2.2 The Transferee intends to use the Subject Space for
purposes which are not permitted under this Lease; 
  
 14.2.3 The
Transferee is either a governmental agency or instrumentality thereof; 
  
 14.2.4 The Transferee is not a party of reasonable financial worth and/or financial stability in light of the responsibilities to be undertaken in connection with the Transfer on the date consent is requested; 
  
 14.2.5 The proposed Transfer would cause a violation of another lease for
space in the Project, or would give an occupant of the Project a right to cancel its lease; 
  
 14.2.6 Either the proposed Transferee; or any person or entity which directly or indirectly, controls, is controlled by, or is under common control with, the proposed Transferee, (i) occupies space in the Project
at the time of the request for consent, or (ii) is negotiating or has negotiated with Landlord to lease space in the Project; 
  
 14.2.7 In Landlord’s reasonable judgment, the use of the Premises by the proposed Transferee would not be comparable to the types of office use by
other tenants in the Project, would result in more than a reasonable density of occupants per square foot of the Premises, would increase the burden on elevators or other Building systems or equipment over the burden thereon prior to the proposed
Transfer, or would require increased services by Landlord; or 
  
 14.2.8 The proposed Transfer would result in the subdivision of the Premises into more than two (2) separately demised parcels at any given time during the Lease Term. 
  
 If Landlord consents to any Transfer pursuant to the terms of this Section 14.2 (and does not exercise any recapture
rights Landlord may have under Section 14.4 of this Lease), Tenant may within six (6) months after Landlord’s consent, but not later than the expiration of said six-month period, enter into such Transfer of the Premises or portion
thereof, upon substantially the same terms and conditions as are set forth in the Transfer Notice furnished by Tenant to Landlord pursuant to Section 14.1 of this Lease, provided that if there are any changes in the 
  

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 terms and conditions from those specified in the Transfer Notice (i) such that Landlord would initially have been
entitled to refuse its consent to such Transfer under this Section 14.2, or (ii) which would cause the proposed Transfer to be more favorable to the Transferee than the terms set forth in Tenant’s original Transfer Notice, Tenant
shall again submit the Transfer to Landlord for its approval and other action under this Article 14 (including Landlord’s right of recapture, if any, under Section 14.4 of this Lease). Notwithstanding anything to the contrary in this
Lease, if Tenant or any proposed Transferee claims that Landlord has unreasonably withheld, conditioned or delayed its consent under Section 14.2 or otherwise has breached or acted unreasonably under this Article 14, their sole remedies shall
be a declaratory judgment and an injunction for the relief sought, and Tenant hereby waives the provisions of Section 1995.310 of the California Civil Code, or any successor statute, and all other remedies, including, without limitation, any
right at law or equity to terminate this Lease, on its own behalf and, to the extent permitted under all applicable laws, on behalf of the proposed Transferee. Tenant shall indemnify, defend and hold harmless Landlord from any and all liability,
losses, claims, damages, costs, expenses, causes of action and proceedings involving any third party or parties (including without limitation Tenant’s proposed subtenant, or assignee) who claim they were damaged by Landlord’s wrongful
withholding or conditioning of Landlord’s consent. 
  
 14.3
Transfer Premium. If Landlord consents to a Transfer, as a condition thereto which the parties hereby agree is reasonable, Tenant shall pay to Landlord fifty percent (50%) of any “Transfer Premium,” as that term is
defined in this Section 14.3, received by Tenant from such Transferee. “Transfer Premium” shall mean all rent, additional rent or other consideration payable by such Transferee in connection with the Transfer in excess of the Rent and
Additional Rent payable by Tenant under this Lease during the term of the Transfer on a per rentable square foot basis if less than all of the Premises is transferred, after deducting the reasonable expenses incurred by Tenant for (i) any
changes, alterations and improvements to the Premises, in connection with the Transfer, (ii) any free base rent reasonably provided to the Transferee in connection with the Transfer, and (iii) any brokerage commissions in connection with
the Transfer (collectively, “Tenant’s Subleasing Costs”). “Transfer Premium” shall also include, but not be limited to, key money, bonus money or other cash consideration paid by Transferee to Tenant in connection with such
Transfer, and any payment in excess of fair market value for services rendered by Tenant to Transferee or for assets, fixtures, inventory, equipment, or furniture transferred by Tenant to Transferee in connection with such Transfer. Tenant shall
make a determination of the amount of Landlord’s applicable share of the Transfer Premium on a monthly basis as rent or other consideration is paid by Transferee to Tenant under the Transfer. For purposes of calculating the Transfer Premium on
a monthly basis, (A) Tenant’s Subleasing Costs shall be deemed to be expended by Tenant in equal monthly amounts over the entire term of the Transfer and (B) the Rent paid for the Subject Space by Tenant shall be computed after
adjusting such rent to the actual effective rent to be paid, taking into consideration any and all leasehold concessions granted in connection therewith, including, but not limited to, any rent credit and tenant improvement allowance. For purposes
of calculating any such effective rent all such concessions shall be amortized on a straight-line basis over the relevant term. 
  
 14.4 Landlord’s Option as to Subject Space. Notwithstanding anything to the contrary contained in this Article 14, Landlord shall have
the option, by giving written notice to Tenant within thirty (30) days after receipt of any Transfer Notice, to recapture the Subject Space. Such recapture shall cancel and terminate this Lease with respect to the Subject Space as 

 

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 of the date stated in the Transfer Notice as the effective date of the proposed Transfer and fully release Tenant from
this Lease with respect to liability for the Subject Space incurred following the date of the Transfer only. In the event of a recapture by Landlord, if this Lease shall be canceled with respect to less than the entire Premises, then (i) the
Rent reserved herein shall be prorated on the basis of the number of rentable square feet retained by Tenant in proportion to the number of rentable square feet contained in the Premises; (ii) this Lease as so amended shall continue thereafter
in full force and effect, and upon request of either party, the parties shall execute written confirmation of the same; and (iii) Landlord shall, using commercially reasonable efforts to minimize interference with Tenant’s use of the
Premises, construct at or cause to be constructed at Landlord’s sole cost and expense, a demising wall separating that portion of the Premises recaptured by Landlord from that portion of the Premises retained by Tenant; provided that, Tenant
thereby agrees that, notwithstanding Tenant’s occupancy of its retained portion of the Premises during the construction of such demising wall by Landlord, Landlord shall be permitted to construct such demising wall during normal business hours,
without any obligation to pay overtime other premiums, and the construction of such demising wall by Landlord shall in no way constitute a constructive eviction of Tenant nor entitle Tenant to any abatement of Rent, and Landlord shall have no
responsibility or for any reason be liable to Tenant for any direct or indirect injury to or interference with Tenant’s business arising from the construction of such demising wall, nor shall Tenant be entitled to any compensation or damages
from Landlord for loss of the use of the whole or any part of its retained portion of the Premises or of Tenant’s personal property or improvements resulting from the construction of such demising wall, or for any inconvenience or annoyance
occasioned by the construction of such demising wall. If Landlord declines, or fails to elect in a timely manner, to recapture the Subject Space under this Section 14.4, then, provided Landlord has consented to the proposed Transfer, Tenant
shall be entitled to proceed to transfer the Subject Space to the proposed Transferee, subject to provisions of this Article 14. 
  
 14.5 Effect of Transfer. If Landlord consents to a Transfer, then (i) the terms and conditions of this Lease shall in no way be deemed
to have been waived or modified; (ii) such consent shall not be deemed consent to any further Transfer by either Tenant or a Transferee; (iii) Tenant shall deliver to Landlord, promptly after execution, an original executed copy of all
documentation pertaining to the Transfer in commercially reasonable form, including, without limitation, at Landlord’s option, a “Transfer Agreement,” as that term is defined in this Section 14.5, below; (iv) Tenant shall
furnish upon Landlord’s request a complete statement, certified by an independent certified public accountant, or Tenant’s chief financial officer, setting forth in detail the computation of any Transfer Premium Tenant has derived and
shall derive from such Transfer; and (v) no Transfer relating to this Lease or agreement entered into with respect thereto, whether with or without Landlord’s consent, shall relieve Tenant or any guarantor of the Lease from any liability
under this Lease, including, without limitation, in connection with the Subject Space, and, in the event of a Transfer of Tenant’s entire interest in this Lease, the liability of Tenant and such Transferee shall be joint and several. Landlord
or its authorized representatives shall have the right at all reasonable times to audit the books, records and papers of Tenant relating to any Transfer, and shall have the right to make copies thereof. If the Transfer Premium respecting any
Transfer shall be found understated, Tenant shall, within thirty (30) days after demand, pay the deficiency, and if understated by more than two percent (2%), Tenant shall pay Landlord’s costs of such audit. Notwithstanding anything to the
contrary contained in this Article 14, Landlord, at its option in its sole and absolute discretion, may 
  

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 require, as a condition to the validity of any Transfer, that both Tenant and such Transferee enter into a separate
written agreement directly with Landlord (a “Transfer Agreement”), which Transfer Agreement, among other things, shall create privity of contract between Landlord and such Transferee with respect to the provisions of this Article 14, and
shall contain such terms and provisions as Landlord may reasonably require, including, without limitation, the following: (A) such Transferee’s agreement to be bound by all the obligations of Tenant under this Lease (including, but not
limited to, Tenant’s, obligation to pay Rent), provided that, in the event of a Transfer of less than the entire Premises, the obligations to which such Transferee shall agree to be so bound shall be prorated on a basis of the number of
rentable square feet of the Subject Space in proportion to the number of square feet in the Premises; (B) such Transferee’s acknowledgment of, and agreement that such Transfer shall be subordinate and subject to, Landlord’s rights
under Section 19.3 of this Lease; and (C) Tenant’s and such Transferee’s recognition of and agreement to be bound by all the terms and provisions of this Article 14, including, but not limited to, any such terms and provisions
which Landlord, at its option, reasonably requires to be expressly set forth in such Transfer Agreement. Upon the occurrence of any default by Transferee under such Transfer, Landlord shall have the right, at its option, but not the obligation, on
behalf of Tenant, to pursue any or all of the remedies available to Tenant under such Transfer or at law or in equity (all of which remedies shall be distinct, separate and cumulative). 
  
 14.6 Occurrence of Default. Any Transfer hereunder, whether or not such Transferee shall have executed a
Transferee Agreement, shall be subordinate and subject to the provisions of this Lease, and if this Lease shall be terminated during the term of any Transfer, then Landlord shall have all of the rights set forth in Section 19.3 of this Lease
with respect to such Transfer. In addition, if Tenant shall be in default under this Lease, then Landlord is hereby irrevocably authorized, as Tenant’s agent and attorney-in-fact, to direct any Transferee to make all payments under or in
connection with a Transfer directly to Landlord (which payments Landlord shall apply towards Tenant’s obligations under this Lease) until such default is cured. Such Transferee shall rely on any representation by Landlord that Tenant is in
default hereunder, without any need for confirmation thereof by Tenant. Upon any assignment, the assignee shall assume in writing all obligations and covenants of Tenant thereafter to be performed or observed under this Lease. No collection or
acceptance of rent by Landlord from any Transferee shall be deemed a waiver of any provision of this Article 14 or the approval of any Transferee or a release of Tenant from any obligation under this Lease, whether theretofore or thereafter
accruing. In no event shall Landlord’s enforcement of any provision of this Lease against any Transferee be deemed a waiver of Landlord’s right to enforce any term of this Lease against Tenant or any other person. 
  
 14.7 Additional Transfers. For purposes of this Lease, the term
“Transfer” shall also include (i) if Tenant is a partnership, the withdrawal or change, voluntary, involuntary or by operation of law, of fifty percent (50%) or more of the partners, or transfer of fifty percent (50%) or
more of partnership interests, within a twelve (12)-month period, or the dissolution of the partnership without immediate reconstitution thereof, and (ii) if Tenant is a closely held corporation (i.e., whose stock is not publicly held and not
traded through an exchange or over the counter), (A) the dissolution, merger, consolidation or other reorganization of Tenant or (B) the sale or other transfer of an aggregate of fifty percent (50%) or more of the voting shares of
Tenant (other than to immediate family members by reason of gift or death), within a twelve 
  

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 (12)-month period, or (C) the sale, mortgage, hypothecation or pledge of an aggregate of fifty percent (50%) or
more of the value of the unencumbered assets of Tenant within a twelve (12)-month period. 
  
 14.8 Non-Transfers. Notwithstanding anything to the contrary contained in this Lease, neither (1) an assignment to a transferee of all or substantially all of the assets of Tenant, (ii) an
assignment of the Premises to a transferee which is the resulting entity of a merger or consolidation of Tenant with another entity, nor (iii) an assignment or subletting of all or a portion of the Premises, to an affiliate of Tenant (an entity
which is controlled by, controls, or is under common control with, Tenant) (each, an “Affiliate”), shall be deemed a Transfer under Article 14 of this Lease, provided that Tenant notifies Landlord of any such assignment or sublease and
promptly supplies Landlord with any documents or information reasonably requested by Landlord regarding such transfer or transferee as set forth in items (i) through (iii) above, and provided that such assignment or sublease is not a
subterfuge by Tenant to avoid its obligations under this Lease. “Control,” as used in this Section 14.8, shall mean the ownership, directly or indirectly, of at least fifty-one percent (51%) of the voting securities of, or
possession of the right to vote, in the ordinary direction of its affairs, of at least fifty-one percent (51%) of the voting interest in, any person or entity. 
  
 ARTICLE 15 
  
 SURRENDER OF PREMISES; OWNERSHIP AND 
 REMOVAL OF TRADE FIXTURES 
  
 15.1
Surrender of Premises. No act or thing done by Landlord or any agent or employee of Landlord during the Lease Term shall be deemed to constitute an acceptance by Landlord of a surrender of the Premises unless such intent is
specifically acknowledged in writing by Landlord. The delivery of keys to the Premises to Landlord or any agent or employee of Landlord shall not constitute a surrender of the Premises or effect a termination of this Lease, whether or not the keys
are thereafter retained by Landlord, and notwithstanding such delivery Tenant shall be entitled to the return of such keys at any reasonable time upon request until this Lease shall have been properly terminated. The voluntary or other surrender of
this Lease by Tenant, whether accepted by Landlord or not, or a mutual termination hereof, shall not work a merger, and at the option of Landlord shall operate as an assignment to Landlord of all subleases or subtenancies affecting the Premises or
terminate any or all such sublessees or subtenancies. 
  
 15.2
Removal of Tenant Property by Tenant. Upon the expiration of the Lease Term, or upon any earlier termination of this Lease, Tenant shall, subject to the provisions of this Article 15, quit and surrender possession of the Premises to
Landlord in as good order and condition as when Tenant took possession and as thereafter improved by Landlord and/or Tenant, reasonable wear and tear and repairs which are specifically made the responsibility of Landlord hereunder excepted. Upon
such expiration or termination, Tenant shall, without expense to Landlord, remove or cause to be removed from the Premises all debris and rubbish, such items of furniture, equipment, business and trade fixtures, free-standing cabinet work, movable
partitions and other articles of personal property owned by Tenant or installed or placed by Tenant at its expense in the Premises, and such similar articles of any other persons claiming 
  

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 under Tenant, as Landlord may, in its sole discretion, require to be removed, and Tenant shall repair at its own expense
all damage to the Premises and Building resulting from such removal. 
  
 ARTICLE 16 
  
 HOLDING OVER

  
 If Tenant holds over after the expiration of the Lease
Term or earlier termination thereof, with the express or implied consent of Landlord, such tenancy shall be from month-to-month only, and shall not constitute a renewal hereof or an extension for any further term, and in such case Rent shall be
payable at a monthly rate equal to one hundred fifty percent (150%) of the Rent applicable during the last rental period of the Lease Term under this Lease. Such month-to-month tenancy shall be subject to every other applicable term, covenant
and agreement contained herein. Nothing contained in this Article 16 shall be construed as consent by Landlord to any holding over by Tenant, and Landlord expressly reserves the right to require Tenant to surrender possession of the Premises to
Landlord as provided in this Lease upon the expiration or other termination of this Lease. The provisions of this Article 16 shall not be deemed to limit or constitute a waiver of any other rights or remedies of Landlord provided herein or at law.
If Tenant fails to surrender the Premises upon the termination or expiration of this Lease, in addition to any other liabilities to Landlord accruing therefrom, Tenant shall protect, defend, indemnify and hold Landlord harmless from all loss, costs
(including reasonable attorneys’ fees) and liability resulting from such failure, including, without limiting the generality of the foregoing, any claims made by any succeeding tenant founded upon such failure to surrender and any lost profits
to Landlord resulting therefrom. 
  
 ARTICLE 17

  
 ESTOPPEL CERTIFICATES 
  
 Within ten (10) business days following a request in Writing by
Landlord, Tenant shall execute, acknowledge and deliver to Landlord an estoppel certificate, which, as submitted by Landlord, shall be substantially in the form of Exhibit E, attached hereto (or such other form as may be reasonably required by any
prospective mortgagee or purchaser of the Project, or any portion thereof), indicating therein any exceptions thereto that may exist at that time, and shall also contain any other information reasonably requested by Landlord or Landlord’s
mortgagee or prospective mortgagee. Any such certificate may be relied upon by any prospective mortgagee or purchaser of all or any portion of the Project. Tenant shall execute and deliver whatever other instruments may be reasonably required for
such purposes. At any time during the Lease Term, Landlord may require Tenant to provide Landlord with a current financial statement and financial statements of the two (2) years prior to the current financial statement year. Such statements
shall be prepared in accordance with generally accepted accounting principles and, if such is the normal practice of Tenant, shall be audited by an independent certified public accountant. Failure of Tenant to timely execute, acknowledge and deliver
such estoppel certificate or other instruments shall permit Landlord to execute the estoppel certificate on behalf of Tenant in a commercially reasonable form. 
  

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 ARTICLE 18 
  
 MORTGAGE OR GROUND LEASE 
  
 18.1 Subordination. This Lease shall be subject and subordinate to all present and future ground or underlying
leases of the Building or Project and to the lien of any mortgage, trust deed or other encumbrances now or hereafter in force against the Building or Project or any part thereof, if any, and to all renewals, extensions, modifications, consolidations
and replacements thereof, and to all advances made or hereafter to be made upon the security of such mortgages or trust, deeds, unless the holders of such mortgages, trust deeds or other encumbrances, or the lessors under such ground lease or
underlying leases, require in writing that this Lease be superior thereto. Tenant covenants and agrees in the event any proceedings are brought for the foreclosure of any such mortgage or deed in lieu thereof (or if any ground lease is terminated),
to attorn, without any deductions or set-offs whatsoever, to the lienholder or purchaser or any successors thereto upon any such foreclosure sale or deed in lieu thereof (or to the ground lessor), if so requested to do so by such purchaser or
lienholder or ground lessor, and to recognize such purchaser or lienholder or ground lessor as the lessor under this Lease, provided such lienholder or purchaser or ground lessor shall agree to accept this Lease and not disturb Tenant’s
occupancy, so long as Tenant timely pays the rent and observes and performs the terms, covenants and conditions of this Lease to be observed and performed by Tenant. Landlord’s interest herein may be assigned as security at any time to any
lienholder. Tenant shall, within five (5) days of request by Landlord, execute such further instruments or assurances as Landlord may reasonably deem necessary to evidence or confirm the subordination or superiority of this Lease to any such
mortgages, trust deeds, ground leases or underlying leases. Tenant waives the provisions of any current or future statute, rule or law which may give or purport to give Tenant any right or election to terminate or otherwise adversely affect this
Lease and the obligations of the Tenant hereunder in the event of any foreclosure proceeding or sale. 
  
 18.2 Notice to Lienholder or Ground Lessor. Notwithstanding anything to the contrary contained in Article 28, below, or elsewhere in this
Lease, upon receipt by Tenant of notice from any holder of a mortgage, trust deed or other encumbrance in force against the Building or the Project or any part thereof which includes the Premises or any lessor under a ground lease or underlying
lease of the Building or the Project, or from Landlord, which notice sets forth the address of such lienholder or ground lessor, no notice from Tenant to Landlord shall be effective unless and until a copy of the same is given to such lienholder or
ground lessor at the appropriate address therefor (as specified in the above-described notice or at such other places as may be designated from time to time in a notice to Tenant in accordance with Article 28, below), and the curing of any of
Landlord’s defaults by such lienholder or ground lessor within a reasonable period of time after such notice from Tenant (including a reasonable period of time to obtain possession of the Building or the Project, as the case may be, if such
lienholder or ground lessor elects to do so) shall be treated as performance by Landlord. For the purposes of this Article 18, the term “mortgage” shall include a mortgage on a leasehold interest of Landlord (but not a mortgage on
Tenant’s leasehold interest hereunder). 
  
 18.3
Assignment of Rents. With reference to any assignment by Landlord of Landlord’s interest in this Lease, or the Rent payable to Landlord hereunder, conditional in nature or otherwise, which assignment is made to any holder of a
mortgage, trust deed or other 
  

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 encumbrance in force against the Building or the Project or any part thereof which includes the Premises or to any lessor
under a ground lease or underlying lease of the Building or the Project, Tenant agrees as follows: 
  
 18.3.1 The execution of any such assignment by Landlord, and the acceptance thereof by such lienholder or ground lessor, shall never be treated as an
assumption by such lienholder or ground lessor of any of the obligations of Landlord under this Lease, unless such lienholder or ground lessor shall, by notice to Tenant, specifically otherwise elect. 
  
 18.3.2 Notwithstanding delivery to Tenant of the notice required by
Section 18.3.1, above, such lienholder or ground lessor, respectively, shall be treated as having assumed Landlord’s obligations under this Lease only upon such lienholder’s foreclosure of any such mortgage, trust deed or other
encumbrance, or acceptance of a deed in lieu thereof, and taking of possession of the Building or the Project or applicable portion thereof, or such ground lessor’s termination of any such ground lease or underlying leases and assumption of
Landlord’s position hereunder, as the case may be. In no event shall such lienholder, ground lessor or any other successor to Landlord’s interest in this Lease, as the case may be, be liable for any security deposit paid by Tenant to
Landlord, unless and until such lienholder, ground lessor or other such successor, respectively, actually has been credited with or has received for its own account as landlord the amount of such security deposit or any portion thereof (in which
event the liability of such lienholder, ground lessor or other such successor, as the case may be, shall be limited to the amount actually credited or received). 
  
 18.3.3 In no event shall the acquisition of title to the Building and the land upon which the Building is located or the
Project or any part thereof which includes the Premises by a purchaser which, simultaneously therewith, leases back to the seller thereof the entire Building or the land upon which the Building is located or the Project or the entirety of that part
thereof acquired by such purchaser, as the case may be, be treated as an assumption, by operation of law or otherwise, of Landlord’s obligations under this Lease, but Tenant shall look solely to such seller-lessee, or to the successors to or
assigns of such seller-lessee’s estate, for performance of Landlord’s obligations under this Lease. In any such event, this Lease shall be subject and subordinate to the lease to such seller-lessee, and Tenant covenants and agrees in the
event the lease to such seller-lessee is terminated to attorn, without any deductions or set-offs whatsoever, to such purchaser-lessor, if so requested to do so by such purchaser-lessor, and to recognize such purchaser-lessor as the lessor under
this Lease, provided such purchaser-lessor shall agree to accept this Lease and not disturb Tenant’s occupancy, so long as Tenant timely pays the rent and observes and performs the terms, covenants and conditions of this Lease to be observed
and performed by Tenant. For all purposes, such seller-lessee, or the successors to or assigns of such seller-lessee’s estate, shall be the lessor under this Lease unless and until such seller-lessee’s position shall have been assumed by
such purchaser-lessor. 
  

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 ARTICLE 19 
  
 DEFAULTS; REMEDIES 
  
 19.1 Events of Default. The occurrence of any of the following shall constitute a default of this Lease by Tenant: 
  
 19.1.1 Any failure by Tenant to pay any Rent or any other charge required to
be paid under this Lease, or any part thereof, when due; provided, however, notwithstanding anything to the contrary set forth in this Section 19.1.1, Tenant’s failure to pay any Rent or any other charge required to be paid under this
Lease, or any part thereof, when due shall constitute a default of this Lease by Tenant only if such failure is not cured within five (5) business days after said amount is due, provided that Tenant theretofore shall not have so failed to pay
any Rent or any other charge within five (5) business days after said amount is due on two (2) occasions during any given Lease Year, in which event Tenant thereafter shall not be entitled to such five (5) business day period; or

  
 19.1.2 Except where a specific time period is otherwise set
forth for Tenant’s performance in this Lease, in which event the failure to perform by Tenant within such time period shall be a default by Tenant under this Section 19.1.2, any failure by Tenant to observe or perform any other provision,
covenant or condition of this Lease to be observed or performed by Tenant where such failure continues for thirty (30) days after written notice thereof from Landlord to Tenant; provided that if the nature of such default is such that the same
cannot reasonably be cured within a thirty (30) day period, Tenant shall not be deemed to be in default if it diligently commences such cure within such period and thereafter diligently proceeds to rectify and cure such default; or 

 
 19.1.3 Abandonment of all or a substantial portion of the Premises by
Tenant; or 
  
 19.1.4 The failure by Tenant to observe or perform
according to the provisions of Articles 5, 10, 14, 17 or 18 of this Lease or the failure by Tenant to observe or perform any other provision, covenant or condition of this Lease which failure, because, of the character of such provision, covenant or
condition, would immediately jeopardize Landlord’s interest, where such failure continues for more than two (2) business days after notice from Landlord; or 
  
 19.1.5 Tenant’s failure to occupy the Premises within ninety (90) days after the Lease Commencement Date.

  
 The notice periods provided in this Section 19.1 are in
lieu of, and not in addition to, any notice periods provided by law. 
  
 19.2 Remedies Upon Default. Upon the occurrence of any event of default by Tenant, Landlord shall have, in addition to any other remedies available to Landlord at law or in equity (all of which remedies shall be distinct,
separate and cumulative), the option to pursue any one or more of the following remedies, each and all of which shall be cumulative and nonexclusive, without any notice or demand whatsoever. 
  
 19.2.1 Terminate this Lease, in which event Tenant shall immediately
surrender the Premises to Landlord, and if Tenant fails to do so, Landlord may, without prejudice to any other remedy which it may have for possession or arrearages in rent, enter upon and take possession of the Premises and expel or remove Tenant
and any other person who may be occupying the Premises or any part thereof, without being liable for prosecution or any claim or damages therefor; and Landlord may recover from Tenant the following: 
  
 (i) The worth at the time of any unpaid rent which has been
earned at the time of such termination; plus 
  

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 (ii) The worth at the time of award of the amount by which the unpaid rent which would
have been earned after termination until the time of award exceeds the amount of such rental loss that Tenant proves could have been reasonably avoided; plus 
  

(iii) The worth at the time of award of the amount by which the unpaid rent for the balance of the Lease Term after the time of award
exceeds the amount of such rental loss that Tenant proves could have been reasonably avoided; plus 
  
 (iv) Any other amount necessary to compensate Landlord for all the detriment proximately caused by Tenant’s failure to perform its
obligations under this Lease or which in the ordinary course of things would be likely to result therefrom, specifically including but not limited to, brokerage commissions and advertising expenses incurred, expenses of remodeling the Premises or
any portion thereof for a new tenant, whether for the same or a different use, and any special concessions made to obtain a new tenant; and 
  
 (v) At Landlord’s election, such other amounts in addition to or in lieu of the foregoing as may be permitted from time to time by
applicable law. 
  
 The term “rent” as used in this Section 19.2
shall be deemed to be and to mean all sums of every nature required to be paid by Tenant pursuant to the terms of this Lease, whether to Landlord or to others. As used in Paragraphs 19.2.1(i) and (ii), above, the “worth at the time of
award” shall be computed by allowing interest at the rate set forth in Article 25 of this Lease, but in no case greater than the maximum amount of such interest permitted by law. As used in Paragraph 19.2.1(iii) above, the “worth at the
time of award” shall be computed by discounting such amount at the discount rate of the Federal Reserve Bank of San Francisco at the time of award plus one percent (1%). 
  
 19.2.2 Landlord shall have the remedy described in California Civil Code Section 1951.4 (lessor may continue lease in
effect after lessee’s breach and abandonment and recover rent as it becomes due, if lessee has the right to sublet or assign, subject only to reasonable limitations). Accordingly, if Landlord does not elect to terminate this Lease on account of
any default by Tenant, Landlord may, from time to time, without terminating this Lease, enforce all of its rights and remedies under this Lease, including the right to recover all rent as it becomes due. 
  
 19.2.3 Landlord shall at all times have the rights and remedies (which shall
be cumulative with each other and cumulative and in addition to those rights and remedies available under Sections 19.2.1 and 19.2.2, above, or any law or other provision of this Lease), without prior demand or notice except as required by
applicable law, to seek any declaratory, injunctive or other equitable relief, and specifically enforce this Lease, or restrain or enjoin a violation or breach of any provision hereof. 
  
 19.3 Subleases of Tenant. If Landlord elects to terminate this Lease on account of any default by Tenant, as
set forth in this Article 19, then Landlord shall have the right, at Landlord’s option in its sole discretion, (i) to terminate any and all assignments, subleases, 
  

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 licenses, concessions or other consensual arrangements for possession entered into by Tenant and affecting the Premises,
in which event Landlord shall have the right to repossess such affected portions of the Premises by any lawful means, or (ii) to succeed to Tenant’s interest in any or all such assignments, subleases, licenses, concessions or arrangements,
in which event Landlord may require any assignees, sublessees, licensees or other parties thereunder to attorn to and recognize Landlord as its assignor, sublessor, licensor, concessionaire or transferor thereunder. In the event of Landlord’s
election to succeed to Tenant’s interest in any such assignments, subleases, licenses, concessions or arrangements, Tenant shall, as of the date of notice by Landlord of such election, have no further right to or interest in the rent or other
consideration receivable thereunder. 
  
 19.4 Efforts to
Relet. No re-entry or repossession, repairs, maintenance, changes, alterations and additions, reletting, appointment of a receiver to protect Landlord’s interests hereunder, or any other action or omission by Landlord shall be construed
as an election by Landlord to terminate this Lease or Tenant’s right to possession, or to accept a surrender of the Premises, nor shall same operate to release Tenant in whole or in part from any of Tenant’s obligations hereunder, unless
express written notice of such intention is sent by Landlord to Tenant. Tenant hereby irrevocably waives any right otherwise available under any law to redeem or reinstate this Lease. 
  
 ARTICLE 20 
  
 COVENANT OF QUIET ENJOYMENT 
  
 Landlord covenants that Tenant, on paying the Rent, charges for services and other payments herein reserved and on keeping, observing and performing all
the other terms, covenants, conditions, provisions and agreements herein contained on the part of Tenant to be kept, observed and performed, shall, during the Lease Term, peaceably and quietly have, hold and enjoy the Premises subject to the terms,
covenants, conditions, provisions and agreements hereof without interference by any persons lawfully claiming by or through Landlord. The foregoing covenant is in lieu of any other covenant express or implied. 
  
 ARTICLE 21 
  
 LETTER OF CREDIT 
  
 21.1 Delivery of Letter of Credit. Tenant shall deliver to
Landlord concurrent with Tenant’s execution of this Lease, an unconditional, clean, irrevocable letter of credit (the “L-C”) in an initial amount of One Hundred Eleven Thousand One Hundred Seventy-One and 06/100 Dollars ($111,171.06),
which L-C shall be issued by a money-center bank (a bank which accepts deposits, maintains accounts, has a local San Francisco office which will negotiate a letter of credit, and whose deposits are insured by the FDIC) reasonably acceptable to
Landlord, and which L-C shall be in a form and content substantially as set forth on Exhibit G, or otherwise commercially reasonably acceptable to Landlord and Tenant. Tenant shall pay all expenses, points and/or fees incurred by Tenant in
obtaining the L-C. 
  

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 21.2 Application of Letter of Credit. The L-C shall be held by Landlord as security for the
faithful performance by Tenant of all the terms, covenants, and conditions of the Lease to be kept and performed by Tenant during the Lease Term. The L-C shall not be mortgaged, assigned or encumbered in any manner whatsoever by Tenant without the
prior written consent of Landlord. If Tenant defaults with respect to any provisions of the Lease, including, but not limited to, the provisions relating to the payment of Rent, or if Tenant fails to renew the L-C at least thirty (30) days
before its expiration, Landlord may, but shall not be required to, draw upon all or any portion of the L-C for payment of any Rent or any other sum in default, or for the payment of any amount that Landlord may reasonably spend or may become
obligated to spend by reason of Tenant’s default, or to compensate Landlord for any other loss or damage that Landlord may suffer by reason of Tenant’s default. The use, application or retention of the L-C, or any portion thereof, by
Landlord shall not prevent Landlord from exercising any other right or remedy provided by the Lease or by law, it being intended that Landlord shall not first be required to proceed against the L-C and shall not operate as a limitation on any
recovery to which Landlord may otherwise be entitled. Any amount of the L-C which is drawn upon by Landlord, but is not used or applied by Landlord, shall be held by Landlord and deemed a security deposit (the “L-C Security Deposit”). If
any portion of the L-C is drawn upon, Tenant shall, within five (5) business days after written demand therefor, either (i) deposit cash with Landlord (which cash shall be applied by Landlord to the L-C Security Deposit) in an amount
sufficient to cause the sum of the L-C Security Deposit and the amount of the remaining L-C to be equivalent to the amount of the L-C then required under the Lease or (ii) reinstate the L-C to the amount then required under the Lease, and if
any portion of the L-C Security Deposit is used or applied, Tenant shall, within five (5) business days after written demand therefor, deposit cash with Landlord (which cash shall be applied by Landlord to the L-C Security Deposit) in an amount
sufficient to restore the L-C Security Deposit to the amount then required under this Lease, and Tenant’s failure to do so shall be a default under the Lease. Tenant acknowledges that Landlord has the right to transfer or mortgage its interest
in the Building and in the Lease and Tenant agrees that in the event of any such transfer or mortgage, Landlord shall have the right to transfer or assign the L-C Security Deposit and/or the L-C to the transferee or mortgagee, and in the event of
such transfer, Tenant shall look solely to such transferee or mortgagee for the return of the Security Deposit and/or the L-C. Tenant shall, within ten (10) business days of request by Landlord, execute such further instruments or assurances as
Landlord may reasonably deem necessary to evidence or confirm Landlord’s transfer or assignment of the L-C Security Deposit and/or the L-C to such transferee or mortgagee. 
  
 ARTICLE 22 
  
 SUBSTITUTION OF OTHER PREMISES 
  
 Landlord shall have the right to relocate Tenant to other space in the Project comparable to the Premises, and all terms hereof shall apply to the new
space with equal force and effect, except as otherwise provided in this Article 22. In such event, Landlord shall give Tenant prior notice of Landlord’s election to so relocate Tenant, and shall move Tenant’s effects to the new space at
Landlord’s sole cost and expense (including costs of re-cabling of Tenant’s computer network located in the Premises) at such time and in such manner as to inconvenience Tenant as little as reasonably practicable. Simultaneously with such
relocation of the Premises, the parties shall immediately execute an amendment to this Lease stating the relocation of the Premises, and 
  

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 amending those Sections of the Summary, and replacing Exhibit A to this Lease, as shall be necessary to accurately
describe the new space (including, without limitation, the location and the rentable area of the new space). In the event Tenant is relocated in accordance with this Article 22, and the rentable area of the new space is not equal to the rentable
area of the Premises, of any such adjustment to the rentable area of the Premises and/or the Building, all amounts, percentages and figures appearing or referred to in this Lease based upon such rentable area (including, without limitation, the
amounts of the “Rent” and the “Security Deposit,” as those terms are defined in Article 4 and Article 21 of this Lease, respectively, and “Tenant’s Share,” as that term is defined in Section 4.2.9 of this
Lease) shall be modified accordingly; provided, however, that notwithstanding the foregoing, (i) in no event shall Tenant be relocated to space consisting of less than ninety percent (90%) of the rentable area of the Premises; and
(ii) Tenant’s Base Rent shall not increase as a result of such relocation. Should Tenant refuse to permit Landlord to move Tenant to the new space, Landlord shall have the right to cancel and terminate this Lease effective sixty
(60) days from the date of Landlord’s election to relocate Tenant. 
  
 ARTICLE 23 
  
 SIGNS 
  
 23.1 Full Floors.
Subject to Landlord’s prior written approval, in its reasonable discretion, and provided all signs are in keeping with the quality, design and style of the Building and Project, Tenant, if the Premises comprise an entire floor of the Building,
at its sole cost and expense, may install identification signage anywhere in the Premises, including in the elevator lobby of the Premises, provided that such signs must not be visible from the exterior of the Building. 
  
 23.2 Multi-Tenant Floors. If other tenants occupy space on the
floor on which the Premises is located, Tenant’s identifying signage shall be provided by Landlord, at Tenant’s cost, and such signage shall be comparable to that used by Landlord for other similar floors in the Building and shall comply
with Landlord’s then-current Building standard signage program. 
  
 23.3 Prohibited Signage and Other Items. Any signs, notices, logos, pictures, names or advertisements which are installed and that have not been separately approved by Landlord may be removed without notice by Landlord at the
sole expense of Tenant. Tenant may not install any signs on the exterior or roof of the Project or the Common Areas. Any signs, window coverings, or blinds (even if the same are located behind the Landlord-approved window coverings for the
Building), or other items visible from the exterior of the Premises or Building, shall be subject to the prior approval of Landlord, in its sole discretion. 
  
 23.4 Building Directory. Tenant shall have the right to one (1) line to display Tenant’s name on the Building directory, which
amount shall be increased as reasonably required by Tenant in the event the Premises are expanded pursuant to the terms of Section 1.3 of this Lease or otherwise. 
  

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 ARTICLE 24 
  
 COMPLIANCE WITH LAW 
  
 Tenant shall not do anything or suffer anything to be done in or about the Premises or the Project which will in any way conflict with any law, statute,
ordinance or other governmental rule, regulation or requirement now in force or which may hereafter be enacted or promulgated. At its sole cost and expense, Tenant shall promptly comply with all such governmental measures. Should any standard or
regulation now or hereafter be imposed on Landlord or Tenant by a state, federal or local governmental body charged with the establishment, regulation and enforcement of occupational, health or safety standards for employers, employees, landlords or
tenants, then Tenant agrees, at its sole cost and expense, to comply promptly with such standards or regulations and to cooperate with Landlord, including, without limitation, by taking such actions as Landlord may reasonably require, in
Landlord’s efforts to comply with such standards or regulations. Tenant shall be responsible, at its sole cost and expense, to make all alterations to the Premises as are required to comply with the governmental rules, regulations, requirements
or standards described in this Article 24. The judgment of any court of competent jurisdiction or the admission of Tenant in any judicial action, regardless of whether Landlord is a party thereto, that Tenant has violated any of said governmental
measures, shall be conclusive of that fact as between Landlord and Tenant. Tenant shall promptly pay all fines, penalties and damages that may arise out of or be imposed because of its failure to comply with the provisions of this Article 24.

  
 ARTICLE 25 
  
 LATE CHARGES 
  
 If any installment of Rent or any other sum due from Tenant shall not be
received by Landlord or Landlord’s designee (i) within five (5) days after said amount is due, or (ii) upon the date said amount is due if any installment of Rent or other sum due from Tenant has not been received by Landlord or
Landlord’s designee within five (5) days after the date due on two (2) or more occasions during any given Lease Year, then Tenant shall pay to Landlord a late charge equal to five percent (5%) of the overdue amount plus any
attorneys’ fees incurred by Landlord by reason of Tenant’s failure to pay Rent and/or other charges when due hereunder. The late charge shall be deemed Additional Rent and the right to require it shall be in addition to all of
Landlord’s other rights and remedies hereunder or at law and shall not be construed as liquidated damages or as limiting Landlord’s remedies in any manner. In addition to the late charge described above, any Rent or other amounts owing
hereunder which are not paid (i) within five (5) days after the date they are due, or (ii) upon the date they are due if any Rent or other amounts owing hereunder have not been received by Landlord or Landlord’s designee within
five (5) days after the date due on two (2) or more occasions during any given Lease Year, shall bear interest from the date when due until paid at a rate per annum equal to the lesser of (i) the annual “Bank Prime Loan”
rate cited in the Federal Reserve Statistical Release Publication G.13(415), published on the first Tuesday of each calendar month (or such other comparable index as Landlord and Tenant shall reasonably agree upon if such rate ceases to be
published) plus four (4) percentage points, and (ii) the highest rate permitted by applicable law; provided that interest shall not be charged upon any late charge applied by Landlord. 
  

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 ARTICLE 26 
  
 LANDLORD’S RIGHT TO CURE DEFAULT; PAYMENTS BY TENANT 
  
 26.1 Landlord’s Cure. All covenants and agreements to be
kept or performed by Tenant under this Lease shall be performed by Tenant at Tenant’s sole cost and expense and without any reduction of Rent, except to the extent, if any, otherwise expressly provided herein. If Tenant shall fail to perform
any obligation under this Lease, and such failure shall continue in excess of the time allowed under Section 19.1.2, above, unless a specific time period is otherwise stated in this Lease, Landlord may, but shall not be obligated to, make any
such payment or perform any such act on Tenant’s part without waiving its rights based upon any default of Tenant and without releasing Tenant from any obligations hereunder. 
  
 26.2 Tenant’s Reimbursement. Except as may be specifically provided to the contrary in this Lease, Tenant
shall pay to Landlord the following, sums (which sums shall bear interest from the date accrued by Landlord until paid by Tenant at a rate per annum equal to interest at the rate set forth in Article 25 of this Lease, but in no case greater than the
maximum amount of such interest permitted by law), upon delivery by Landlord to Tenant of statements therefor: (i) sums equal to expenditures reasonably made and obligations reasonably incurred by Landlord in connection with the remedying by
Landlord of Tenant’s defaults pursuant to the provisions of Section 26.1; (ii) sums equal to all losses, costs, liabilities, damages and expenses referred to in Article 10 of this Lease; and (iii) sums equal to all reasonable
expenditures made and obligations incurred by Landlord in collecting or attempting to collect the Rent or in enforcing or attempting to enforce any tights of Landlord under this Lease or pursuant to law, including, without limitation, all legal fees
and other amounts so expended. Tenant’s obligations under this Section 26.2 shall survive the expiration or sooner termination of the Lease Term. 
  
 ARTICLE 27 
  
 ENTRY BY LANDLORD 
  
 Landlord reserves the right at all reasonable times and upon reasonable prior written notice to Tenant (which notice shall not be required in the case of
an emergency) to enter the Premises to (i) inspect them; (ii) show the Premises to prospective purchasers or, during the last twelve (12) months of the then-current Lease Term, to tenants, or to current or prospective mortgagees,
ground or underlying lessors or insurers; (iii) post notices of nonresponsibility; or (iv) alter, improve or repair the Premises or the Building, or for structural alterations, repairs or improvements to the Building or the Building’s
systems and equipment. Notwithstanding anything to the contrary contained in this Article 27, Landlord may enter the Premises at any time to (A) perform services required of Landlord, including janitorial service; (B) take possession due
to any breach of this Lease in the manner provided herein; and (C) perform any covenants of Tenant which Tenant fails to perform. Landlord may make any such entries without the abatement of Rent and may take such reasonable steps as reasonably
required to accomplish the stated purposes. Tenant hereby waives any claims for damages or for any injuries or inconvenience to or interference with Tenant’s business, lost profits, any loss of occupancy or quiet enjoyment of the Premises, and
any other loss occasioned thereby. For each of the above purposes, Landlord shall at all times have a key with which to unlock all the doors 
  

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 in the Premises, excluding Tenant’s vaults, safes and special security areas designated in advance by Tenant. In an
emergency, Landlord shall have the right to use any means that Landlord may deem proper to open the doors in and to the Premises. Any entry into the Premises by Landlord in the manner hereinbefore described shall not be deemed to be a forcible or
unlawful entry into, or a detainer of, the Premises, or an actual or constructive eviction of Tenant from any portion of the Premises. No provision of this Lease shall be construed as obligating Landlord to perform any repairs, alterations or
decorations except as otherwise expressly agreed to be performed by Landlord herein. Notwithstanding anything to the contrary set forth above, Tenant may designate certain reasonable areas of the Premises as “Secured Areas” should Tenant
require such areas for the purpose of securing certain valuable property or confidential information. Landlord may not enter such Secured Areas except in the case of emergency. In connection with any entry into the Premises pursuant to this Article
27 (except in the case of an emergency or in connection with items (A) or (B), above), Landlord shall not enter the Premises unless accompanied by a representative of Tenant, provided Tenant makes a representative available at the time of such
entry. 
  
 ARTICLE 28 
  
 NOTICES 
  
 All notices, demands, statements, designations, approvals or other
communications (collectively, “Notices”) given or required to be given by either party to the other hereunder or by law shall be in writing, shall be (A) sent by United States certified or registered mail, postage prepaid, return
receipt requested (“Mail”), (B) transmitted by telecopy, if such telecopy is promptly followed by a Notice sent by Mail, (C) delivered by a nationally recognized overnight courier, or (D) delivered personally. Any Notice
shall be sent, transmitted, or delivered, as the case may be, to Tenant at the appropriate address set forth in Section 9 of the Summary, or to such other place as Tenant may from time to time designate in a Notice to Landlord, or to Landlord
at the addresses set forth below, or to such other places as Landlord may from time to time designate in a Notice to Tenant. Any Notice will be deemed given (i) three (3) days after the date it is posted if sent by Mail, (ii) the date
the telecopy is transmitted, (iii) the date the overnight courier delivery is made, or (iv) the date personal delivery is made. Any Notice given by an attorney on behalf of Landlord or by Landlord’s managing agent shall be considered
as given by Landlord and shall be fully effective. As of the date of this Lease, any Notices to Landlord must be sent, transmitted, or delivered, as the case may be, to the following addresses: 
  
 Boston Properties Limited Partnership 
 Four Embarcadero Center 
 Lobby Level, Suite
One 
 San Francisco, California 94111 
 Attention: Mr. Robert Pester 
  
 and 

 

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 Boston Properties, Inc. 
 Prudential Center 
 800 Boylston Street 
 Boston, Massachusetts 02199-8001 
 Attention: General Counsel 
  
 and 
  
 Allen, Matkins, Leck, Gamble & Mallory 
 1901 Avenue of the Stars 
 Suite 1800

 Los Angeles, California 90067 
 Attention: Anton N. Natsis, Esq. 
  
 ARTICLE 29

  
 MISCELLANEOUS PROVISIONS 
  
 29.1 Terms; Captions. The words “Landlord” and
“Tenant” as used herein shall include the plural as well as the singular. The necessary grammatical changes required to make the provisions hereof apply either to corporations or partnerships or individuals, men or women, as the case may
require, shall in all cases be assumed as though in each case fully expressed. The captions of Articles and Sections are for convenience only and shall not be deemed to limit, construe, affect or alter the meaning of such Articles and Sections.

  
 29.2 Binding Effect. Subject to all other
provisions of this Lease, each of the covenants, conditions and provisions of this Lease shall extend to and shall, as the case may require, bind or inure to the benefit not only of Landlord and of Tenant, but also of their respective heirs,
personal representatives, successors or assigns, provided this clause shall not permit any assignment by Tenant contrary to the provisions of Article 14 of this Lease. 
  
 29.3 No Light, Air or View Rights. No rights to any view or to light or air over any property, whether
belonging to Landlord or any other person, are granted to Tenant by this Lease. Under no circumstances whatsoever at any time during the Lease Term shall any temporary darkening of any windows of the Premises or any temporary obstruction of the
light or view therefrom by reason of any repairs, improvements, maintenance or cleaning in or about the Project, or any diminution, impairment or obstruction (whether partial or total) of light, air or view by any structure which may be erected on
any land comprising a part of, or located adjacent to or otherwise in the path of light, air or view to, the Project, in any way impose any liability upon Landlord or in any way reduce or diminish Tenant’s obligations under this Lease.

  
 29.4 Modification of Lease. Should any
current or prospective mortgagee or ground lessor for the Building or Project require a modification of this Lease, which modification will not cause an increased cost or expense to Tenant or in any other way materially and adversely change the
rights and obligations of Tenant hereunder, then and in such event, Tenant agrees that this Lease may be so modified and agrees to execute whatever documents are reasonably required therefor and to deliver the same to Landlord within ten
(10) business days following a 
  

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 request therefor. At the request of Landlord or any mortgagee or ground lessor, Tenant agrees to execute a short form of
Lease and deliver the same to Landlord within ten (10) days following the request therefor. 
  
 29.5 Transfer of Landlord’s Interest. Tenant acknowledges that Landlord has the right to transfer all or any portion of its interest in
the Project or Building and in this Lease, and Tenant agrees that in the event of any such transfer, Landlord shall automatically be released from all liability under this Lease and Tenant agrees to look solely to such transferee for the performance
of Landlord’s obligations hereunder after the date of transfer and such transferee shall be deemed to have fully assumed and be liable for all obligations of this Lease to be performed by Landlord, including the return of any L-C or L-C
Security Deposit, and Tenant shall attorn to such transferee. 
  
 29.6 Prohibition Against Recording. Except as provided in Section 29.4 of this Lease, neither this Lease, nor any memorandum, affidavit or other writing with respect thereto, shall be recorded by Tenant or by anyone
acting through, under or on behalf of Tenant. 
  
 29.7
Landlord’s Title. Landlord’s title is and always shall be paramount to the title of Tenant. Nothing herein contained shall empower Tenant to do any act which can, shall or may encumber the title of Landlord. 
  
 29.8 Relationship of Parties. Nothing contained in this Lease
shall be deemed or construed by the parties hereto or by any third party to create the relationship of principal and agent, partnership, joint venturer or any association between Landlord and Tenant. 
  
 29.9 Application of Payments. Landlord shall have the right to
apply payments received from Tenant pursuant to this Lease, regardless of Tenant’s designation of such payments, to satisfy any obligations of Tenant hereunder, in such order and amounts as Landlord, in its sole discretion, may elect.

  
 29.10 Time of Essence. Time is of the essence
with respect to the performance of every provision of this Lease in which time of performance is a factor, including, without limitation, the giving of any Notice required to be given under this Lease or by law, the time periods for giving any such
Notice and the taking of any action with respect to any such Notice. 
  
 29.11 Partial Invalidity. If any term, provision or condition contained in this Lease shall, to any extent, be invalid or unenforceable, the remainder of this Lease, or the application of such term, provision or condition to
persons or circumstances other than those with respect to which it is invalid or unenforceable, shall not be affected thereby, and each and every other term, provision and condition of this Lease shall be valid and enforceable to the fullest extent
possible permitted by law. 
  
 29.12 No Warranty. In
executing and delivering this Lease, Tenant has not relied on any representations, including, but not limited to, any representation as to the amount of any item comprising Additional Rent or the amount of the Additional Rent in the aggregate or
that Landlord is furnishing the same services to other tenants, at all, on the same level or on the same basis, or any warranty or any statement of Landlord which is not set forth herein or in one or more of the exhibits attached hereto. 

 

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 29.13 Landlord Exculpation. The liability of Landlord or the Landlord Parties to Tenant for
any default by Landlord under this Lease or arising in connection herewith or with Landlord’s operation, management, leasing, repair, renovation, alteration or any other matter relating to the Project or the Premises shall be limited solely and
exclusively to an amount which is equal to the interest of Landlord in the Building, provided that in no event shall such liability extend to any sales or insurance proceeds received by Landlord or the Landlord Parties in connection with the
Project, Building or Premises. Neither Landlord, nor any of the Landlord Parties shall have any personal liability therefor, and Tenant hereby expressly waives and releases such personal liability on behalf of itself and all persons claiming by,
through or under Tenant. The limitations of liability contained in this Section 29.13 shall inure to the benefit of Landlord’s and the Landlord Parties’ present and future partners, beneficiaries, officers, directors, trustees,
shareholders, agents and employees, and their respective partners, heirs, successors and assigns. Under no circumstances shall any present or future partner of Landlord (if Landlord is a partnership), or trustee or beneficiary (if Landlord or any
partner of Landlord is a trust), have any liability for the performance of Landlord’s obligations under this Lease. Notwithstanding any contrary provision herein, neither Landlord nor the Landlord Parties shall be liable under any circumstances
for any indirect or consequential damages or any injury or damage to, or interference with, Tenant’s business, including but not limited to, loss of profits, loss of rents or other revenues, loss of business opportunity, loss of goodwill or
loss of use, in each case, however occurring. 
  
 29.14
Entire Agreement. It is understood and acknowledged that there are no oral agreements between the parties hereto affecting this Lease and this Lease constitutes the parties’ entire agreement with respect to the leasing of the
Premises and supersedes and cancels any and all previous negotiations, arrangements, brochures, agreements and understandings, if any, between the parties hereto or displayed by Landlord to Tenant with respect to the subject matter thereof, and none
thereof shall be used to interpret or construe this Lease. None of the terms, covenants, conditions or provisions of this Lease can be modified, deleted or added to except in writing signed by the parties hereto. 
  
 29.15 Right to Lease. Landlord reserves the absolute right to
effect such other tenancies in the Project as Landlord in the exercise of its sole business judgment shall determine to best promote the interests of the Building or Project. Tenant does not rely on the fact, nor does Landlord represent, that any
specific tenant or type or number of tenants shall, during the Lease Term, occupy any space in the Building or Project. 
  
 29.16 Force Majeure. Any prevention, delay or stoppage due to strikes, lockouts, labor disputes, acts of God, inability to obtain services,
labor, or materials or reasonable substitutes therefor, governmental actions, civil commotions, fire or other casualty, and other causes beyond the reasonable control of the party obligated to perform, except with respect to the obligations imposed
with regard to Rent and other charges to be paid by Tenant pursuant to this Lease (collectively, a “Force Majeure”), notwithstanding anything to the contrary contained in this Lease, shall excuse the performance of such party for a period
equal to any such prevention, delay or stoppage and, therefore, if this Lease specifies a time period for performance of an obligation of either party, that time period shall be extended by the period of any delay in such party’s performance
caused by a Force Majeure. 
  

 -48- 

 29.17 Waiver of Redemption by Tenant. Tenant hereby waives, for Tenant and for all those
claiming under Tenant, any and all rights now or hereafter existing to redeem by order or judgment of any court or by any legal process or writ, Tenant’s right of occupancy of the Premises after any termination of this Lease. 
  
 29.18 Tenant Parking. Tenant may utilize, on a month-to-month
basis, up to three and one-tenth (3.1) non-transferable parking passes for unreserved parking spaces per each 1,000 rentable square feet of the Premises in the Project parking facility, which parking passes shall be free of charge throughout
the initial Lease Term only. Tenant shall be responsible for the full amount of any taxes imposed by any governmental authority in connection with the use of the parking facility by Tenant. Tenant shall supply Landlord with an identification roster
listing, for each parking pass, the name of the employee and the make, color and registration number of the vehicle to which such parking pass has been assigned, and shall provide a revised roster to Landlord monthly indicating changes thereto.
Tenant’s continued right to use the parking passes is conditioned upon Tenant abiding by all rules and regulations which are reasonably prescribed from time to time for the orderly operation and use of the parking facility where the parking
passes are located, including any sticker or other identification system established by Landlord, Tenant’s cooperation in seeing that Tenant’s employees and visitors also comply with such rules and regulations and Tenant not being in
default under this Lease. Landlord specifically reserves the right to change the size, configuration, design, layout and all other aspects of the Project parking facility at any time and Tenant acknowledges and agrees that Landlord may, without
incurring any liability to Tenant and without any abatement of Rent under this Lease, from time to time, close-off or restrict access to the Project parking facility for purposes of permitting or facilitating any such construction, alteration or
improvements. Landlord may delegate its responsibilities hereunder to a parking operator in which case such parking operator shall have all the rights of control attributed hereby to the Landlord. The parking passes utilized by Tenant pursuant to
this Section 29.18 are provided to Tenant solely for use by Tenant’s own personnel and such passes may not be transferred, assigned, subleased or otherwise alienated by Tenant without Landlord’s prior approval. Tenant may validate
visitor parking by such method or methods as the Landlord may reasonably establish, at the validation rate from time to time generally applicable to visitor parking. 
  
 29.19 Joint and Several. If there is more than one Tenant, the obligations imposed upon Tenant under this
Lease shall be joint and several. 
  
 29.20
Authority. If Tenant is a corporation, trust or partnership, each individual executing this Lease on behalf of Tenant hereby represents and warrants that Tenant is a duly formed and existing entity qualified to do business in
California and that Tenant has full right and authority to execute and deliver this Lease and that each person signing on behalf of Tenant is authorized to do so. In such event, Tenant shall, within ten (10) business days after execution of
this Lease, deliver to Landlord satisfactory evidence of such authority and, if a corporation, upon demand by Landlord, also deliver to Landlord satisfactory evidence of (i) good standing in Tenant’s state of incorporation and
(ii) qualification to do business in California. 
  

 -49- 

 29.21 Attorneys’ Fees. In the event that either Landlord or Tenant should bring suit
for the possession of the Premises, for the recovery of any sum due under this Lease, or because of the breach of any provision of this Lease or for any other relief against the other, then all costs and expenses, including reasonable
attorneys’ fees, incurred by the prevailing party therein shall be paid by the other party, which obligation on the part of the other party shall be deemed to have accrued on the date of the commencement of such action and shall be enforceable
whether or not the action is prosecuted to judgment. 
  
 29.22
Governing Law; WAIVER OF TRIAL BY JURY. This Lease shall be construed and enforced in accordance with the laws of the State of California. IN ANY ACTION OR PROCEEDING ARISING HEREFROM, LANDLORD AND TENANT HEREBY CONSENT TO (I) THE
JURISDICTION OF ANY COMPETENT COURT WITHIN THE STATE OF CALIFORNIA, (II) SERVICE OF PROCESS BY ANY MEANS AUTHORIZED BY CALIFORNIA LAW, AND (III) IN THE INTEREST OF SAVING TIME AND EXPENSE, TRIAL WITHOUT A JURY IN ANY ACTION, PROCEEDING OR
COUNTERCLAIM BROUGHT BY EITHER OF THE PARTIES HERETO AGAINST THE OTHER OR THEIR SUCCESSORS IN RESPECT OF ANY MATTER ARISING OUT OF OR IN CONNECTION WITH THIS LEASE, THE RELATIONSHIP OF LANDLORD AND TENANT, TENANT’S USE OR OCCUPANCY OF THE
PREMISES, AND/OR ANY CLAIM FOR INJURY OR DAMAGE, OR ANY EMERGENCY OR STATUTORY REMEDY. IN THE EVENT LANDLORD COMMENCES ANY SUMMARY PROCEEDINGS OR ACTION FOR NONPAYMENT OF BASE RENT OR ADDITIONAL RENT, TENANT SHALL NOT INTERPOSE ANY COUNTERCLAIM OF
ANY NATURE OR DESCRIPTION (UNLESS SUCH COUNTERCLAIM SHALL BE MANDATORY) IN ANY SUCH PROCEEDING OR ACTION, BUT SHALL BE RELEGATED TO AN INDEPENDENT ACTION AT LAW. 
  
 29.23 Submission of Lease. Submission of this instrument for examination or signature by Tenant does not
constitute a reservation of, option for or option to lease, and it is not effective as a lease or otherwise until execution and delivery by both Landlord and Tenant. 
  
 29.24 Brokers. Landlord and Tenant hereby warrant to each other that they have had no dealings with any real
estate broker or agent in connection with the negotiation of this Lease, excepting only the real estate brokers or agents specified in Section 11 of the Summary (the “Brokers”), and that they know of no other real estate broker or
agent who is entitled to a commission in connection with this Lease. Each party agrees to indemnify and defend the other party against and hold the other party harmless from any and all claims, demands, losses, liabilities, lawsuits, judgments,
costs and expenses (including without limitation reasonable attorneys’ fees) with respect to any leasing commission or equivalent compensation alleged to be owing on account of any dealings with any real estate broker or agent, other than the
Brokers, occurring by, through, or under the indemnifying party. 
  
 29.25 Independent Covenants. This Lease shall be construed as though the covenants herein between Landlord and Tenant are independent and not dependent and Tenant hereby expressly waives the benefit of any statute to the
contrary and agrees that if Landlord fails to perform its obligations set forth herein, Tenant shall not be entitled to make any repairs or perform any acts hereunder at Landlord’s expense or to any setoff of the Rent or other amounts owing
hereunder against Landlord. 
  

 -50- 

 29.26 Project or Building Name and Signage. Landlord shall have the right at any time to
change the name of the Project or Building and to install, affix and maintain any and all signs on the exterior and on the interior of the Project or Building as Landlord may, in Landlord’s sole discretion, desire. Tenant shall not use the
words “Gateway Center” or the name of the Project or Building or use pictures or illustrations, of the Project or Building in advertising or other publicity or for any purpose other than as the address of the business to be conducted by
Tenant in the Premises, without the prior written consent of Landlord. 
  
 29.27 Counterparts. This Lease may be executed in counterparts with the same effect as if both parties hereto had executed the same document. Both counterparts shall be construed together and shall constitute a single lease.

  
 29.28 Confidentiality. Tenant acknowledges that
the content of this Lease and any related documents are confidential information. Tenant shall keep such confidential information strictly confidential and shall not disclose such confidential information to any person or entity other than
Tenant’s financial, legal, and space planning consultants. 
  
 29.29 Development of the Project. 
  
 29.29.1 Subdivision. Landlord reserves the right to further subdivide all or a portion of the Project. Tenant agrees to execute and deliver, upon reasonable request by Landlord and in a commercially reasonable form, any
additional documents reasonably needed to conform this Lease to the circumstances resulting from such subdivision. 
  
 29.29.2 The Other Improvements. If portions of the Project or property adjacent to the Project (collectively, the “Other
Improvements”) are owned by an entity other than Landlord, Landlord, at its option, may enter into an agreement with the owner or owners of any or all of the Other Improvements to provide (i) for reciprocal rights of access and/or use of
the Project and the Other Improvements, (ii) for the common management, operation, maintenance, improvement and/or repair of all or any portion, of the Project and the Other Improvements, (iii) for the allocation of a portion of the Direct
Expenses to the Other Improvements and the operating expenses and taxes for the Other Improvements to the Project, and (iv) for the use or improvement of the Other Improvements and/or the Project in connection with the improvement,
construction, and/or excavation of the Other Improvements and/or the Project. Nothing contained herein shall be deemed or construed to limit or otherwise affect Landlord’s right to convey all or any portion of the Project or any other of
Landlord’s rights described in this Lease. 
  
 29.29.3
Construction of Project and Other Improvements. Tenant acknowledges that portions of the Project and/or the Other Improvements may be under construction following Tenant’s occupancy of the Premises, and that such construction may
result in levels of noise, dust, odor, obstruction of access, etc. which are in excess of that present in a fully constructed project. Tenant hereby waives any and all rent offsets or claims of constructive eviction which may arise in connection
with such construction. 
  
 29.30 Building
Renovations. It is specifically understood and agreed that Landlord has no obligation and has made no promises to alter, remodel, improve, renovate, repair or decorate 
  

 -51- 

 the Premises, Building, or any part thereof and that no representations respecting the condition of the Premises or the
Building have been made by Landlord to Tenant except as specifically set forth herein. However, Tenant hereby acknowledges that Landlord is currently renovating or may during the Lease Term renovate, improve, alter, or modify (collectively, the
“Renovations”) the Project, the Building and/or the Premises. Tenant hereby agrees that such Renovations shall in no way constitute a constructive eviction of Tenant nor entitle Tenant to any abatement of Rent. Landlord shall have no
responsibility and shall not be liable to Tenant for any injury to or interference with Tenant’s business arising from the Renovations, nor shall Tenant be entitled to any compensation or damages from Landlord for loss of the use of the whole
or any part of the Premises or of Tenant’s personal property or improvements resulting from the Renovations, or for any inconvenience or annoyance occasioned by such Renovations. 
  
 29.31 No Violation. Each party hereby warrants and represents that neither its execution of nor performance
under this Lease shall cause such party to be in violation of any agreement, instrument, contract, law, rule or regulation by which such party is bound, and such party shall protect, defend, indemnify and hold the other party harmless against any
claims, demands, losses, damages, liabilities, costs and expenses, including, without limitation, reasonable attorneys’ fees and costs, arising from such party’s breach of this warranty and representation. 
  
 29.32 Communications and Computer Lines. Tenant may install,
maintain, replace, remove or use any communications or computer wires and cables (collectively, the “Lines”) at the Project in or serving the Premises, provided that (i) Tenant shall obtain Landlord’s prior written consent, which
consent shall not be unreasonably withheld, conditioned or delayed, use an experienced and qualified contractor approved in writing by Landlord, and comply with all of the other provisions of Articles 7 and 8 of this Lease, (ii) an acceptable
number of spare Lines and space for additional Lines shall be maintained for existing and future occupants of the Project, as determined in Landlord’s reasonable opinion, (iii) the Lines therefor (including riser cables) shall be
appropriately insulated to prevent excessive electromagnetic fields or radiation, and shall be surrounded by a protective conduit reasonably acceptable to Landlord, (iv) any new or existing Lines servicing the Premises shall comply with all
applicable governmental laws and regulations, (v) as a condition to permitting the installation of new Lines, Landlord may require that Tenant remove existing Lines located in or serving the Premises and repair any damage in connection with
such removal, and (vi) Tenant shall pay all costs in connection therewith. Landlord reserves the right to require that Tenant remove any Lines located in or serving the Premises which are installed in violation of these provisions, or which are
at any time in violation of any laws or represent a dangerous or potentially dangerous condition. Landlord further reserves the right to require that Tenant remove any and all Lines located in or serving the Premises upon the expiration of the Lease
Term or upon any earlier termination of this Lease. 
  
 29.33
No Discrimination. There shall be no discrimination against, or segregation of, any person or persons on account of sex, marital status, race, color, religion, creed, national origin or ancestry in the Transfer of the Premises, or any
portion thereof, nor shall the Tenant itself, or any person claiming under or through it, establish or permit any such practice or practices of discrimination or segregation with reference to the selection, location, number, use or occupancy of
tenants, lessees, subtenants, sublessees, or vendees of the Premises, or any portion thereof. 
  

 -52- 

 IN WITNESS WHEREOF, Landlord and Tenant have caused this Lease to be executed the day and date first
above written. 
  

					
	“Landlord”:
	
	 GATEWAY CENTER, LLC,
 a California limited
liability company

		
	By:	 	 /s/ [illegible]

	 	 	Its:	 	  

		
	By:	 	  

	 	 	Its:	 	  

	
	“Tenant”:
	
	 D-NOVO THERAPEUTICS, INC.,
 a Delaware
corporation

		
	By:	 	 /s/ Brad Goodwin

	Name:	 	Brad Goodwin
	Title:	 	CEO
	Date:	 	3/12/02
		
	By:	 	  

	Name:	 	  

	Title:	 	  

	Date:	 	  

  

 -53- 

 EXHIBIT A 
  
 601 GATEWAY BOULEVARD 
  

OUTLINE OF PREMISES 
  
 

 
  
 EXHIBIT A 
  

 -1- 

 EXHIBIT B 
  
 601 GATEWAY BOULEVARD 
  

INTENTIONALLY DELETED 
  
 EXHIBIT B 
  

 -1- 

 EXHIBIT C 
  
 STANDARDS FOR UTILITIES AND SERVICES 
  
 1. Elevators. Provide non-attended passenger elevators to and from the floor(s) on which the Premises are located.
Landlord may limit the number of elevators operating outside normal business hours. Landlord shall not charge Tenant for regular elevator use. 
  
 2. HVAC. On Monday through Friday, except holidays, from 7:00 a.m. to 6:00 p.m., ventilate the Premises and furnish air conditioning or heating on
such days and hours, in temperatures and amounts which in Landlord’s good faith judgment are reasonably required for comfortable occupancy of the Premises under normal business operations. If Tenant requires air conditioning during other hours,
Landlord will furnish same through an access system provided to Tenant at the Premises, if available, or otherwise as specified in a written request of Tenant delivered to the Building management office before noon on the preceding business day. For
this service Tenant will pay Landlord, upon receipt of Landlord’s statement, the charge at an hourly rate determined by Landlord from time to time, which is currently $35.00 per hour. Tenant agrees that neither Tenant nor any Tenant Party shall
at any time enter mechanical installations or facilities of the Building or adjust, tamper with, touch or otherwise in any manner affect said installations or facilities. The cost of maintenance and service calls to adjust and regulate the air
conditioning system shall be charged to Tenant if the need for maintenance work results from either Tenant’s adjustment of room thermostats or Tenant’s failure to comply with Landlord’s rules governing the temperature within the
Premises. 
  
 3. Lighting. Furnish electric lighting for
all public areas and special service areas of the Building as Landlord determines in good faith to be reasonable and standard, including replacement of Building standard lights, bulbs and tubes. 
  
 4. Electrical Service. Subject to the limitation of this Paragraph 4,
furnish electrical service to the Premises, including providing and installing all Building standard replacement lighting tubes. If Tenant uses more electrical power than Landlord in good faith considers reasonable or normal for office use, Tenant
will pay Landlord on a monthly basis the cost of such excess power consumed by Tenant. Consumption will be determined, at Landlord’s election, either (a) by a survey performed by a reputable consultant selected by Landlord, or
(b) through separate meters or submeters installed, maintained and read by Landlord at Tenant’s cost. For purposes of this Paragraph 4 only, “month” and “monthly” shall mean any billing period used by the utility or
other power provider supplying electricity. All installations of electrical futures, appliances and equipment within the Premises shall be subject to Landlord’s prior approval, and if they affect the temperature or humidity otherwise
maintained, Landlord may, at Tenant’s sole cost and expense (to be paid within (30) days after delivery of written demand supported by invoices or other reasonably satisfactory evidence), install supplemental air conditioning units.
Tenant’s use of electricity shall never exceed Tenant’s share of the capacity of existing feeders to the Building or of the risers, wiring installations and transformers serving the floor(s) containing the Premises. Landlord shall provide
up to 3.5 watts per usable square foot (demand) of riser and floor panel electrical capacity averaged over the floor being serviced. 
  
 EXHIBIT C 
  

 -1- 

 Tenant shall be allocated an approximate 2.0 watts per usable square foot for power and 1.5 watts per usable square foot
for lighting. Any risers or wiring necessary to meet Tenant’s excess electrical requirements will be installed by Landlord on Tenant’s request, at Tenant’s sole cost and expense (to be paid in advance), but only if in Landlord’s
reasonable good faith belief they are necessary and will not cause damage to the Building or a dangerous condition, entail excessive or unreasonable alterations, repairs or expense, or disturb other occupants. 
  
 5. Water. Provide toilet facilities, water for lavatory and toilet
purposes, cold water for drinking and tepid water for lavatory purposes, all at points of supply provided for general use of tenants in the Building through fixtures installed by Landlord or by Tenant with Landlord’s consent. 
  
 6. Janitorial. Provide janitorial service to the Premises an business
days and other cleaning services as Landlord determines to be reasonably required. Tenant will pay Landlord the full cost attributable to any extraordinary janitorial or cleaning services which the Premises may require. 
  
 7. Maintenance of Non-Building Standard Items. Maintenance and service
costs necessary for non-building standard items in the Premises shall be the responsibility of Tenant. As used in this paragraph, non-building standard items shall include, without limitation, heat pumps, condenser pumps, sinks and associated drain
pipes, faucets, hot water heaters, garbage disposals, dishwashers, refrigerators, ice makers, air conditioning units, projection screens and associated wiring and switching, incandescent downlight or wallwash fixtures and lamps, floor electrical
outlets and power poles. 
  
 8. Security Services. Provide
Building security personnel twenty-four (24) hours per day, seven (7) days per week, fifty-two (52) weeks per year and a card access system which allows access to individual office floors twenty-four (24) hours per day, seven
(7) days per week, fifty-two (52) weeks per year, all of which shall be provided by Landlord in its sole and absolute discretion. Notwithstanding Landlord’s providing security, Tenant waives any claim against Landlord with respect to
any loss by theft or any other damage suffered or incurred by Tenant in connection with any entry into the Premises or any other breach of security with respect to the Premises or the Building, except due to the gross negligence or willful
misconduct of Landlord. 
  
 Landlord reserves the right to adopt
reasonably, nondiscriminatory modifications and additions to these standards, which Landlord shall promptly deliver to Tenant in writing. 
  
 EXHIBIT C 
  

 -2- 

 EXHIBIT D 
  
 601 GATEWAY BOULEVARD 
  

NOTICE OF LEASE TERM DATES 
  

									
	 To:
	 	  

	 	 	 	 	 	 
	 	 	  

	 	 	 	 	 	 
	 	 	  

	 	 	 	 	 	 
	 	 	  

	 	 	 	 	 	 

  

			
	Re:	  	Office Lease dated                     , 200   between
                            , a
	 	  	                                    
(“Landlord”), and
                                        ,
a
	 	  	                                    
(“Tenant”) concerning Suite                      on floor(s)
                    
	 	  	of the office building located at
                                        
                                       
 .

  
 Gentlemen: 
  
 In accordance with the Office Lease (the “Lease”), we wish to
advise you and/or confirm as follows: 
  

	 	1.	The Lease Term shall commence on or has commenced on                     
for a term of                      ending on
                    . 

  

	 	2.	Rent commenced to accrue on                     , in the amount of
                    . 

  

	 	3.	If the Lease Commencement Date is other than the first day of the month, the first billing will contain a pro rata adjustment. Each billing thereafter, with the exception of the
final billing, shall be for the full amount of the monthly installment as provided for in the Lease. 

  

	 	4.	Your rent checks should be made payable to                     at
                    . Pursuant to Article 2 of the Lease, we hereby request that you sign this letter where indicated below, confirming the
information provided above and return it to our office at your earliest convenience. 

  

					
	“Landlord”:	 	 
	  
  

	 	 ,
  

	 a
	 	  

	 	 
	 By:
	 	  

	 	 
	 Its:
	 	  

	 	 

  
 EXHIBIT D

  

 -1- 

					
	 Agreed to and Accepted as
	 	 
	 of
                            , 200  .
	 	 
		
	 “Tenant”:
	 	 
	  
  

	 	 ,
  

	 a
	 	  

	 	 
			
	 By:
	 	  

	 	 
	 Its:
	 	  

	 	 
			
	 By:
	 	  

	 	 
	 Its:
	 	  

	 	 

  
 EXHIBIT D 

 

 -2- 

 EXHIBIT E 
  
 601 GATEWAY BOULEVARD 
  

RULES AND REGULATIONS 
  
 1. Signs. Except as specifically provided in this Lease to which these rules and regulations are attached, no sign, placard, picture,
advertisement, name or notice shall be installed or displayed on any part of the outside or inside of the Building or on the Common Areas or other areas of the Development without Landlord’s prior written consent. Landlord may remove, at
Tenant’s expense and without notice, any sign installed or displayed in violation of this rule. All signs or lettering on doors and walls must be approved by Landlord, and shall be printed, painted, affixed or inscribed or modified at
Tenant’s expense by a person approved by Landlord. Without Landlord’s written consent, Tenant shall not use the name of the Building or the Development in connection with or in promoting or advertising the business of Tenant except as
Tenant’s address. Landlord and Tenant acknowledge that the existing signage on the monument located on the Development next to the Building is to be removed and, subject to the provisions of this Lease, Tenant shall have the right to place
signage on the monument, at its sole expense, until such time that the monument is removed. Landlord hereby agrees to provide Tenant with the Building’s standard graphics at the entrance to the Premises and in the elevator lobby. 
  
 2. Window Treatments. Tenant shall not place anything against or near
glass partitions or doors or windows which may appear unsightly from outside the Premises. Tenant shall be held responsible for any damage to the glass coating within the Premises. If Landlord objects in writing to any curtains, blinds, shades,
screens or hanging plants or other similar objects attached to or used in connection with any external window or door of the Premises, or placed on any windowsill, which are visible from the exterior of the Premises, Tenant shall immediately
discontinue such use. 
  
 3. Common Areas. The sidewalks,
entrances, halls, corridors, elevators and stairways of the Building and the Development shall not be obstructed or used as a waiting or lounging place by Tenant and the Tenant’s Parties. All entrance doors leading from the Premises to the
hallways are to be kept closed at all times. The outside areas immediately adjoining the Premises shall be kept clear at all times by Tenant, and Tenant shall not place or permit any obstructions, garbage, refuse, merchandise or displays in such
areas. The halls, passages, exits, entrances, elevators, escalators and stairways are not open to the general public, but are open, subject to reasonable regulations, to Tenant’s Parties. Landlord shall, in all cases, retain the right to
control and prevent access thereto of all persons whose presence in the judgment of Landlord would be prejudicial to the safety of the Development or any part thereof provided that nothing herein contained shall be construed to prevent such access
to persons with whom any tenant normally deals in the ordinary course of its business, unless such persons are engaged in illegal or unlawful activities. Neither Tenant nor any Tenant Parties shall go upon the roof of the Buildings. 
  
 EXHIBIT E 
  

 -1- 

 4. Directory. The directory of the Building will be provided for the display of the name and
location of tenants, and Landlord reserves the right to exclude any other names therefrom. Tenant shall be allocated its pro rata share of lines on the Building directory board in the main lobby. 
  
 5. Cleanliness. Tenant shall not exhibit carelessness or indifference
to the good order and cleanliness of the Premises. 
  
 6.
Keys. Landlord will furnish Tenant, free of charge, with two keys to each exterior door lock in the Premises. All duplicate keys shall be purchased only from Landlord. Landlord may charge a reasonable fee for any additional keys. Tenant shall
not make or have made additional keys, and Tenant shall not alter any lock or install a new additional lock or bolt on any door of its Premises. Tenant, upon the termination of its tenancy, shall deliver to Landlord the keys to all doors and pay
Landlord for any lost keys. 
  
 7. Security Devices. If
Tenant requires telephonic, burglar alarm or similar services, it shall first obtain and comply with Landlord’s instructions for their installation. 
  
 8. Freight Elevators. The Building service elevator shall be available for use by all tenants in the Building, subject to such reasonable
scheduling by Landlord. No equipment, materials, furniture, packages, supplies, merchandise or other property will be received in the Building or carried in the elevators except between such hours and in such elevators as may be designated by
Landlord. Tenant’s initial move-in and subsequent deliveries of bulky items, such as furniture, safes and similar items shall be made after obtaining Landlord’s written consent and shall be made during the hours of 12:00 a.m. to 5:00 a.m.
and 6:00 p.m. to 11:59 p.m., Monday through Friday, or at any time on Saturday or Sunday, unless otherwise agreed in writing by Landlord. Deliveries during normal office hours shall be limited to normal office supplies and other small items. No
deliveries shall be made which impede or interfere with other tenants or the operation of the Building. 
  
 9. Floor Load. Tenant shall not place a load upon any floor of the Premises which exceeds the load per square foot which such floor was designed to
carry and which is allowed by law. Prior to delivery of any heavy object to the Building, Tenant shall notify Landlord of such object’s specifications and contemplated location in order that Landlord may take action to prevent structural load
damage to the Building. Landlord shall have the right to reasonably prescribe the weight, size and position of all equipment, materials, furniture or other property brought into the Building. Heavy objects shall, if considered necessary by Landlord,
stand on such platforms as reasonably determined by Landlord to be necessary to properly distribute the weight, which platforms shall be provided at Tenant’s sole cost and expense. Tenant shall be responsible for all structural engineering
required to determine structural load. Business machines and mechanical equipment belonging to Tenant which cause noise or vibration that may be transmitted to the structure of the Building or to any space therein to such degree as to be
objectionable to Landlord or to any tenants in the Building, shall be placed and maintained by Tenant, at Tenant’s sole cost and expense, on vibration eliminators or other devices sufficient to eliminate noise or vibration. The persons employed
to move such equipment in or out of the Building must be reasonably acceptable to Landlord. Landlord will not be responsible for loss of, or damage to, any such equipment or other property from any cause, and all damage done to the Building by
maintaining or moving such equipment or other property shall be repaired at the expense of Tenant. 
  
 EXHIBIT E 
  

 -2- 

 10. No Waste. Tenant shall not use any method of heating and air conditioning other than that
supplied by Landlord. Further, Tenant shall not waste electricity, water or air conditioning and agrees to cooperate fully with Landlord to assure the most effective operation of the Building’s heating and air conditioning and to comply with
any governmental energy-saving rules, laws or regulations of which Tenant has actual notice. Tenant shall keep corridor doors closed, and shall close window coverings at the end of each business day. 
  
 11. Building Identification. Landlord reserves the right, exercisable
without notice and without liability to Tenant, to change the name and address of the Building and/or any other part of the Development. 
  
 12. Building Access. Landlord reserves the right to exclude from the Building between the hours of 12:00 a.m. to 7:00 a.m. and 6:00 p.m. to 11:59
p.m., Monday through Friday, and on Saturday, Sunday and holidays, any person not having a Building issue key and is not identified on the daily access list. Tenant shall be responsible for all persons for whom it requests passes and shall be liable
to Landlord for all acts of such persons. Landlord may prevent access to the Development or any part thereof in case of invasion, mob, riot, public excitement or other commotion. Landlord may exclude or expel from the Development or any part thereof
any person who, in Landlord’s judgment, is intoxicated or under the influence of liquor or drugs or is in violation of any of the rules and regulations of the Development. Landlord shall not be liable for damages for any error with regard to
the admission to or exclusion from the Development or any part thereof of any person. 
  
 13. Building Security. Before Tenant and the Tenant Parties leave the Premises each day, Tenant shall (a) close and lock the doors of its Premises, (b) shut off all water faucets and other utilities,
(c) draw or lower window coverings, and (d) turn out all lights. Tenant shall be responsible for any damage or injuries sustained by other tenants or occupants of the Building or by Landlord for noncompliance with this rule. 
  
 14. Outside Services. Tenant shall not obtain for use on the Premises,
drinking water, food, beverage, towel or other similar services or accept barbering or bootblacking service upon the Premises, except as such hours and under such regulations as may be fixed by Landlord. Canvassing, soliciting and distribution of
handbills or any other written material, and peddling in the Building are prohibited, and Tenant shall cooperate to prevent such activities. 
  
 15. Lavatories. The toilet rooms, toilets, urinals, wash bowls and other apparatus shall not be used for any purpose other than that for which they
were constructed and no foreign substance of any kind whatsoever shall be thrown therein. The expense of any breakage, stoppage or damage resulting from the violation of this rule shall be borne by the tenant who, or whose Tenant Parties, shall have
caused it. 
  
 16. Solicitation. Tenant shall not make any
room-to-room solicitation of business from other tenants in the Development or any part thereof. 
  
 EXHIBIT E 
  

 -3- 

 17. Electronic Devices. Tenant shall not install any radio or television antenna, loudspeaker or
other devices on the roof or exterior walls of the Building. Tenant shall not interfere with radio or television broadcasting or reception from or in the Building or elsewhere. 
  
 18. Trash Disposal. Tenant shall store all its trash and garbage within the Premises or in other facilities provided
by Landlord. Tenant shall not place in any trash box or receptacle any material which cannot be disposed of in the ordinary and customary manner of trash and garbage disposal. All garbage and refuse disposal shall be made in accordance with
directions issued from time to time by Landlord. 
  
 19.
Prohibited Uses. The Premises shall not be used for (a) the keeping of any bicycles, motorcycles or animals of any kind, or (b) lodging, or (c) for manufacturing of any kind; nor shall the Premises be used for any illegal
purpose. No cooking or heating of food is permitted on the Premises, excepting therefrom microwave ovens and equipment for brewing coffee, tea, hot chocolate and similar beverages. Such cooking and heating devices and their use should be approved by
Underwriters Laboratories in accordance with all applicable insurance regulations and federal, state, county and city laws, codes, ordinances, rules and regulations. Tenant shall not install, maintain or operate upon the Premises any vending
machines without the written consent of Landlord, which consent shall not be unreasonably withheld. 
  
 20. Prohibited Equipment. Tenant shall not use in any space or in the public halls of the Development any hand truck except those equipped with
rubber tires and side guards or such other material-handling equipment as Landlord may approve. Tenant shall not bring any other vehicles of any kind into the Building. 
  
 21. Safety Procedures. Tenant shall comply with all safety, fire protection and evacuation procedures and regulations
established by Landlord or any governmental agency. 
  
 22.
Premises Security. Tenant assumes full responsibility for protecting its space from theft, robbery and pilferage, which includes keeping doors locked and other means of entry to the Premises closed and secure. Landlord shall not in any way be
responsible to Tenants or any Tenant Party, for any loss of property from the Premises or public areas or for any damage to any property thereon from any cause whatsoever. 
  
 23. Building Management. Tenant’s requirements will be attended to only upon appropriate application to the
Building management office by an authorized individual. Employees of Landlord shall not perform any work or do anything outside of their regular duties unless under special instructions from Landlord, and no employee of Landlord will admit any
person (Tenant or otherwise) to any office without specific instructions from Landlord. 
  
 24. Waiver. Landlord may waive any one or more of these Rules and Regulations for the benefit of Tenant or any other tenant, but no such waiver by Landlord shall be construed as a waiver of such Rules and
Regulations in favor of Tenant or any other tenant, nor prevent Landlord from thereafter enforcing any such Rules and Regulations against any or all of the tenants of the Building. 
  
 EXHIBIT E 
  

 -4- 

 25. Integration. These Rules and Regulations are in addition to, and shall not be construed to in
any way modify or amend, in whole or in part, the terms, covenants, agreements and conditions of the Lease. 
  
 26. Additional Regulations. Landlord reserves the right to make such other and reasonable rules and regulations as, in its judgment, may from time
to time be needed for safety and security, for care and cleanliness of the Development of any part thereof and for the preservation of good order therein. Tenant agrees to abide by all such Rules and Regulations hereinabove stated and any additional
rules and regulations which are adopted and delivered to Tenant in writing. 
  
 27. Observance of Rules. Tenant shall be responsible for the observance of all of the foregoing rules by Tenant’s employees, agents, clients, customers, invitees, licensees and guests. 
  
 28. Parking Facilities. The following rules and regulations shall
govern use of the parking facilities within the Common Areas appurtenant to the Development (such parking facilities being collectively referred to hereinafter as the “Parking Area”). 
  
 28.1 Persons using the Parking Area shall obey all signs and shall park only
in areas designated for vehicle parking within painted stall lines. Tenant’s parking spaces shall be used only for parking vehicles no longer than full-sized passenger automobiles. Tenant shall not permit any vehicle that belongs to or is
controlled by Tenant, its agents, employees, invitees, licensees and visitors, to be loaded, unloaded or parked in areas other than those designated by Landlord or its parking operator for such activities. No maintenance, washing, waxing or cleaning
of vehicles shall be permitted in the Parking Area. Unless otherwise instructed, each person using the Parking Area shall park and lock his or her own vehicle. Neither Landlord nor its parking operator shall be liable for damage to any vehicle,
injury to any person or loss of any property, all of which risks are assumed by the person using the Parking Area. Parking pursuant to this Lease is intended as a license only, and no bailment is intended or created hereby. Tenant shall abide by
those rules promulgated by Landlord which provide for tandem parking. No overnight or extended term storage of any vehicles or other object shall be permitted. 
  

28.2 Persons using the Parking Area shall comply with any parking identification system established by Landlord or its parking operator. Such a system
may include the validation of visitor parking, at the validation rate applicable to visitor parking from time to time as set by Landlord or its parking operator. Parking stickers or other identification devices supplied by Landlord shall remain the
property of Landlord. Such devices shall not be transferable, and any such device in the possession of an unauthorized holder may be retained by Landlord and declared void. Upon the loss or obliteration of a parking identification device, Tenant
shall pay such reasonable replacement charge as may be established by Landlord or its parking operator. Upon the termination of parking privileges, all parking identification devices supplied by Landlord shall be returned to Landlord. Landlord may
refuse the sale of monthly stickers or other parking identification devices to any tenant or person and/or his agents or representatives who willfully refuse to comply with these Rules and Regulations and all unposted city, state or federal
ordinances, laws, or agreements. Loss or theft of parking 
  
 EXHIBIT E 
  

 -5- 

 identification devices from automobiles must be reported to the garage manager immediately, and a lost or stolen report
must be filed by the customer at that time. Landlord may exclude any car from the parking facilities that does not have a identification device. Any parking identification devices reported lost or stolen found on any unauthorized car will be
confiscated and the illegal holder will be subject to prosecution. Lost or stolen devices found by the purchaser must be reported to the parking facility office immediately to avoid confusion. 
  
 28.3 The speed limit within all parking areas shall be five (5) miles
per hour. 
  
 28.4 Landlord reserves the right to modify,
redesign or redesignate uses permitted in the Parking Area or any portion thereof, to relocate parking spaces from floor to floor, from one portion of the Parking Area to another or to reasonably adjacent offsite locations, and to allocate parking
spaces between compact and standard sizes from time to time, as long as the same comply with applicable laws and ordinances. Reserved parking spaces shall be clearly and prominently marked as such by Landlord. But neither Landlord nor its parking
operator shall be liable or responsible for the failure of persons to observe such markings or to obey other rules and regulations, agreements, laws or ordinances applicable to the Parking Area. Without limiting the generality of the foregoing,
Landlord shall not be obligated to tow any violator’s vehicle, or to declare a default under or terminate the lease of any other tenant of the Building, on account of any such failure. If for any reason Landlord is unable to provide to Tenant
all or any portion of its parking spaces or Tenant is unreasonably denied access thereto during the initial term of this Lease or any renewal or extension hereof, such fact shall not be a default by Landlord or permit Tenant to terminate this Lease,
either in whole or in part, but Tenant’s obligation to pay rental for any parking space which is not provided by Landlord shall be abated for so long as Tenant does not have the use of such parking space, in full settlement of all claims that
Tenant might otherwise have against Landlord by reason of Landlord’s failure or inability to provide Tenant with such parking space. 
  
 Tenant shall be responsible for the compliance with all of the foregoing rules and regulations by Tenant and Tenant Parties. Landlord may refuse to permit any person who
violates any such rules and regulations to have access to the Development or any part thereof. Landlord reserves the right from time to time to modify the rules and regulations set forth herein, including, without limitation, to adopt and modify
such rules and regulations applicable to the Parking Area, as it deems necessary for the proper operation. 
  
 EXHIBIT E 
  

 -6- 

 EXHIBIT F 
  
 601 GATEWAY BOULEVARD 
  

FORM OF TENANT’S ESTOPPEL CERTIFICATE 
  
                                 , a [PLEASE PROVIDE]
(“Tenant”) hereby certifies to                      as follows: 
  
 1. Attached hereto is a true, correct and complete copy of a lease dated,
                     2000, between Landlord and Tenant (the “Lease”), which demised premises located at 651/601 Gateway Boulevard,
Suite             , South San Francisco, California 94080 (“Property”). The Lease is now in full force and effect and has been amended, modified, supplemented, extended,
renewed or assigned by and only by the following described agreements, copies of which are attached hereto (if none, so indicate), all of which (together with the Lease) are hereby ratified: 
  

			
	 ________________________________________                                
                
	 	 
		
	 ________________________________________                                
                
	 	 

  
 2. The term of this
Lease commenced on                     , 2000 and will expire on
                    , 200  . 
  
 3. Tenant has accepted and is now in possession of said premises. 
  

4. Tenant and Landlord acknowledge [that the Lease will be assigned to
                                 and] that no modification, adjustment,
revision or cancellation of the Lease or amendments thereto shall be effective unless written consent of
                                 is obtained, and that until further notice,
payments under the Lease may continue as heretofore. 
  
 5. The
amount of fixed monthly rent is $             Tenant is paying in full lease rental, which has been paid in full as of the date hereof. No rent under the Lease has been paid for more
than thirty (30) days in advance of its due date. 
  
 6. The
amount of security deposit or letter of credit held by Landlord (if any) is $            . No other security deposits have been made. 
  
 7. All work required to be performed by Landlord or Tenant under the Lease
has been performed, except for the following (if none, so indicate)
                                . 
  
 8. There are no defaults on the part of the Landlord or Tenant under the
Lease, except for the following (if none, so indicate)
                                . 
  
 9. Tenant has no defense as to its obligations under the Lease and claims no
setoff or counterclaim against Landlord, except for the following (if none, so indicate)
                                . 
  
 EXHIBIT F 
  

 -1- 

 10. Tenant has no right to any concession (rental or otherwise) or similar compensation in connection
with renting the space it occupies except as provided in the Lease, except for the following (if none, so indicate)
                            . 
  
 The foregoing certification is made with the knowledge that
                             is about to (fund a loan to) (purchase the Property from) Landlord and
that said party is relying upon the representations herein made in (funding such loan) (making such purchase). 
  
 Dated:                     ,
20    . 
  

			
	 TENANT:
	 	  

	                     a
[PLEASE PROVIDE]

		
	 By:
	 	  

	 Name:
	 	  

	 Title:
	 	  

		
	 By:
	 	  

	 Name:
	 	  

	 Title:
	 	  

  
 EXHIBIT F

  

 -2- 

 EXHIBIT G 
  
 601 GATEWAY BOULEVARD 
  

FORM OF LETTER OF CREDIT 
 (Letterhead of a money center bank 
 acceptable to the Lessor) 
  
                             , 2002 
  
 GATEWAY CENTER, LLC 
 c/o Boston Properties Limited Partnership 
 Four Embarcadero Center 
 Lobby Level, Suite One 
 San Francisco, California 94111 
 Attention: Mr. Robert Pester 
  
 Ladies and
Gentlemen: 
  
 We hereby establish our Irrevocable Letter of
Credit and authorize you to draw on us at sight for the account of D-NOVO THERAPEUTICS, INC., a Delaware corporation (“Company”), the aggregate amount of One Hundred Eleven Thousand One Hundred Seventy-One and 06/100 Dollars ($111,171.06).

  
 Funds under this Letter of Credit are available to the
beneficiary hereof as follows: 
  
 Any or all of the slims
hereunder may be drawn down at any time and from time to time from and after the date hereof by 
  

							
	 	 	 Gateway Center, LLC,
 a Delaware limited
liability company

			
	 	 	By:	 	  

	 	 	 	 	Its:	 	  

			
	 	 	 By:
	 	  

	 	 	 	 	Its:	 	  

  
 (“Beneficiary”) when accompanied by this Letter of Credit and a written statement signed by a representative of Beneficiary, certifying that Company is in default under the terms of its lease with Beneficiary and such moneys are
due and owing to Beneficiary. 
  
 This Letter of Credit is
transferable in its entirety. Should a transfer be desired, such transfer will be subject to the return to us of this advice, together with written instructions. 
  
 The amount of each draft must be endorsed on the reverse hereof by the negotiating bank. We hereby agree that this Letter of
Credit shall be duly honored upon presentation and delivery of the certification specified above. 
  
 EXHIBIT G 
  

 -1- 

 This Letter of Credit shall expire on
                                . 
  
 Notwithstanding the above expiration date of this Letter of Credit, the term
of this Letter of Credit shall be automatically renewed for successive, additional one (1) year periods unless, at least thirty (30) days prior to any such date of expiration, the undersigned shall give written notice to Beneficiary, by
certified mail, return receipt requested and at the address set forth above or at such other address as may be given to the undersigned by Beneficiary, that this Letter of Credit will not be renewed. 
  
 This Letter of Credit is governed by the Uniform Customs and Practice for
Documentary Credits (1993 Revision), International Chamber of Commerce Publication 500. 
  

			
	Very truly yours,
	(Name of Issuing Bank)
		
	By:	 	  

  
 EXHIBIT G

  

 -2-Amended and Restated First Amendment to Lease, dated as of September 1, 2004

 EXHIBIT 10.15 
  
 AMENDED AND RESTATED FIRST AMENDMENT TO LEASE 
  
 This Amended and Restated First Amendment to Lease (this “Restated Amendment”) is entered into effective as of the 1st day of
September, 2004, by and between GATEWAY CENTER LLC, a Delaware limited liability company (“Landlord”) and NOVACEA, INC., a Delaware corporation (“Tenant”). 
  
 RECITALS 
  
 A. Landlord and Tenant’s predecessor in interest, D-Novo Therapeutics, Inc., previously
entered into that certain Office Lease dated March 1, 2002 (the “Lease”) whereby Landlord leased to Tenant and Tenant leased from Landlord Four Thousand Three Hundred Nineteen (4,319) rentable square feet of space on the fourth
(4th) floor of the building known as 601 Gateway Boulevard, South San Francisco, CA 94080 (the “Building”) commonly known as Suite 450 (the “Premises”). 
  
 B. Tenant is currently a subtenant under that certain “Sublease” effective as of January 1, 2003 (the “Sublease”),
between Tenant, as sublessee thereunder, and Elan Pharmaceuticals, Inc., as sublessor thereunder, wherein Tenant is subleasing Eighteen Thousand Eight Hundred Twenty (18,820) rentable square feet of space consisting of the entire eighth
(8th) floor of the Building (the “Sublet Premises”). The Sublease expires by its terms on December 14, 2004. 
  
 C. The parties hereto have previously entered into that certain “First Amendment to Lease” dated June 23, 2004 (the “First Amendment”), whereby
the Sublet Premises was added to the Premises demised under the Lease; however, the Lease Term with respect to the Sublet Premises extended beyond the Lease Term, which expires as of March 31, 2005. 
  
 D. The parties hereto now desire to enter into this Restated Amendment to clarify the terms
and conditions of the lease of the Sublet Premises, and Landlord and Tenant hereby agree that this Restated Amendment shall replace and supercede the First Amendment, and that from and after the full execution of this Restated Amendment the First
Amendment shall be deemed void and of no further force and effect. 
  
 NOW,
THEREFORE, in consideration of the mutual covenants and agreements herein contained, and other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the parties hereto agree as follows: 
  
 AGREEMENT 
  
 1. Recitals. The foregoing recitals are true and correct and are incorporated herein
by this reference. 
  
 2. Defined Terms. All capitalized terms used in this
Amendment that are not defined herein shall have the meanings as defined in the Lease. 
  
 3. Lease of Sublet Premises. As of December 15, 2004 (the “Sublet Premises Commencement Date”), Tenant hereby leases the Sublet Premises from Landlord, and Landlord hereby leases the Sublet Premises to Tenant, on the
terms and conditions hereinafter set forth. 

 
As of the Sublet Premises Commencement Date, the Sublet Premises shall be added to the Premises demised under the Lease. Section 2.2 of the Summary is
hereby amended by adding the Sublet Premises as of the Sublet Premises Commencement Date. 
  
 4. Lease Term for Premises. Landlord and Tenant hereby agree that the Lease Term for the original Premises (Suite 450) shall expire on March 31, 2005. On or before March 31, 2005, Tenant shall return
possession of the original Premises (Suite 450) to Landlord in the condition required by the terms of the Lease. 
  
 5. Lease Term for Sublet Premises. Notwithstanding that the Lease Term for the original Premises (Suite 450) shall expire on March 31, 2005, the Lease Term
for the Sublet Premises shall commence on the Sublet Premises Commencement Date and shall expire on June 14, 2005 (the “Sublet Premises Termination Date”). The period from the Sublet Premises Commencement Date to the Sublet Premises
Termination Date shall be known as the “Sublet Premises Term.” Section 3.3 of the Summary is hereby amended by making the Lease Expiration Date for the Sublet Premises only June 14, 2005. 
  
 6. Option to Extend the Sublet Premises Term. Landlord hereby grants to Tenant herein
one (1) option to extend the Sublet Premises Term (the “Extension Option”) for a period of six (6) months (“Option Term”). The Option Term shall be exercisable only by written notice delivered by Tenant to Landlord as
provided in Subsection (i) below, provided that, as of the date of delivery of such notice, the Lease is in full force and effect, and there is no default by Tenant under the Lease beyond any applicable notice and cure periods provided in the
Lease. Upon the proper exercise of the Extension Option, and provided that, as of the end of the Sublet Premises Term there is no default by Tenant under the Lease beyond the applicable notice and cure periods provided in the Lease and the other
conditions to exercise of such Extension Option are still true, the Sublet Premises Term, as it applies to the Sublet Premises, shall be extended for an additional period of six (6) months. In the event that, as of the end of the Sublet
Premises Term there is a default by Tenant under the Lease beyond the applicable notice and cure periods provided in the Lease, Landlord, at its option, may (i) honor the Extension Option and extend the Lease for the Option Term, or
(ii) elect to declare the Extension Option null and void, in which event the lease of the Sublet Premises shall expire as of the expiration of the Sublet Premises Term. 
  
 (i) Exercise of Option. If Tenant wishes to exercise the Extension Option, then Tenant shall deliver written notice
to Landlord of its intent to exercise the Extension Option, which written notice must be received by Landlord not later than February 28, 2005. In the event that Tenant shall fail to timely and properly exercise the Extension Option, such
Extension Option shall be deemed, at the option of Landlord, to be null and void and of no further force and effect. 
  
 (ii) Base Rent During Option Term. The Base Rent payable during the Option Term shall be equal to One Dollar and Eighty Cents ($1.80) per square
foot per month, multiplied by the rentable square footage of the Sublet Premises, or Thirty Three Thousand Eight Hundred Seventy Six Dollars ($33,876.00) per month. 
  

 2 

 (iii) Restrictions on Extension Option. The Extension Option granted herein is personal to the
original Tenant executing this Amendment, and notwithstanding anything to the contrary contained in the Lease, the rights contained in this Amendment are not assignable or transferable by such original Tenant. Landlord grants the rights contained
herein to Tenant in consideration of Tenant’s strict compliance with the provisions hereof, including, without limitation, the manner of exercise of the Extension Option. 
  
 7. Base Year for Sublet Premises. Notwithstanding anything to the contrary in the Lease, the Base Year with respect to the Sublet
Premises only shall be calendar year 2005. Section 5 of the Summary is hereby amended accordingly as of the Sublet Premises Commencement Date. 
  
 8. Base Rent for Sublet Premises. The Base Rent payable during the Sublet Premises Term shall be equal to One Dollar and Eighty Cents ($1.80) per square foot per
month, multiplied by the rentable square footage of the Sublet Premises, or Thirty Three Thousand Eight Hundred Seventy Six Dollars ($33,876.00) per month. Section 4 of the Summary is hereby amended accordingly as of the Sublet Premises
Commencement Date. 
  
 9. Tenant’s Share for Sublet Premises.
Notwithstanding anything to the contrary in the Lease, the Tenant’s Share with respect to the Sublet Premises only shall be 8.7221%. Section 6 of the Summary is hereby amended accordingly as of the Sublet Premises Commencement Date.

  
 10. Termination of Right of First Offer to Extend the Lease Term.
Pursuant to Section 1.3 of the Lease, Landlord has granted to Tenant a right of first offer to extend the Lease Term on the original Premises (Suite 450) (the “Extension Right”). Landlord and Tenant hereby agree that, as of the date
hereof, the Extension Right is void and of no further force and effect. Section 1.3 of the Lease is hereby amended accordingly. 
  
 11. Termination of Right of First Offer to Lease Additional Space. Pursuant to Section 1.3 of the Lease, Landlord has granted to Tenant a right of first offer
to lease Suite 460 in the Building (the “Offer Right”). Landlord and Tenant hereby agree that, as of the date hereof, the Offer Right is void and of no further force and effect. Section 1.3 of the Lease is hereby amended accordingly.

  
 12. Ratification of Lease. Landlord and Tenant hereby acknowledge that,
due to an error in drafting by Landlord the Lease was originally executed by Landlord as “Gateway Center LLC, a California limited liability company.” The actual legal entity constituting Landlord is “Gateway Center LLC, a
Delaware limited liability company.” Landlord and Tenant hereby ratify the original Lease. 
  
 13. Real Estate Brokers. Tenant hereby represents and warrants to Landlord that Tenant has not authorized or employed, or acted by implication to authorize or employ, any real estate broker or salesperson to
act for it in connection with this Amendment and the extension of the Lease term contemplated herein, other than BT Commercial Real Estate representing Tenant. Tenant shall indemnify, defend and hold the Landlord harmless from and against any and
all claims by any real estate broker or salesperson whom Tenant authorized or employed, or acted by implication to authorize or employ, to act for Tenant in connection with this Amendment, other than BT Commercial Real Estate. 
  

 3 

 14. No Change. Except as set forth herein, all of the terms and conditions of the Lease remain unchanged and in
full force and effect. 
  
 IN WITNESS WHEREOF, Landlord and Tenant
have executed this Amendment as of the day and date first written above. 
  

													
	Landlord:	  	 	  	Tenant:
			
	 GATEWAY CENTER, LLC,
	  	 	  	NOVACEA, INC.,
	 a Delaware limited liability company
	  	 	  	a Delaware corporation
					
	By:	  	BOSTON PROPERTIES LIMITED
PARTNERSHIP,	  	 	  	By:	 	 /s/ Brad Goodwin

	 	  	a Delaware limited partnership,	  	 	  	Name:	 	Brad Goodwin
	 	  	its sole member	  	 	  	Title:	 	Chief Executive Officer
						
	 	  	By:	  	BOSTON PROPERTIES, INC.	  	 	  	 	 	 
	 	  	 	  	a Delaware corporation,	  	 	  	 
	 	  	 	  	its general partner	  	 	  	 	 	 
							
	 	  	 	  	By:	 	 /s/ Bob Pester

	  	 	  	By:	 	 /s/ Edward C. Albini

	 	  	 	  	Name:	 	Bob Pester	  	 	  	Name:	 	Edward C. Albini
	 	  	 	  	Title:	 	 Senior Vice President and
 Regional
Manager
	  	 	  	Title:	 	Chief Financial Officer

  

 4

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