Document:

exv10w21

Exhibit 10.21

SECOND AMENDMENT TO

ASSET PURCHASE AGREEMENT

     THIS SECOND AMENDMENT TO ASSET PURCHASE AGREEMENT (this “Second Amendment”) is entered into as
of November 16, 2005, by and between CORNERSTONE PHARMACEUTICALS LTD., an Anguilla company
(“Cornerstone”), and VINTAGE PHARMACEUTICALS, LLC, a Delaware limited liability company
(“Vintage”).

RECITALS:

     A. Cornerstone and Vintage are parties to that certain Asset Purchase Agreement, dated as of
July 20, 2004 (the “Agreement”), as amended in May, 2005;

     B. The parties desire to amend certain provisions of the Agreement.

     NOW, THEREFORE, in consideration of the premises and mutual agreements herein contained, the
parties hereby agree as follows:

     SECTION 1. DEFINED TERMS. Capitalized terms used in this Second Amendment, unless
otherwise defined herein, shall have the meanings given such terms in the Agreement.

     SECTION 2. RECITALS. The recitals set forth above are incorporated herein by
reference, as if fully restated herein.

     SECTION 3. STATUS OF AGREEMENT. The Agreement, as amended, hereby remains in full
force and effect, and, except to the extent expressly set forth in this Second Amendment, shall not
be deemed waived, modified, superseded or otherwise affected in any respect.

     SECTION 4. AMENDMENTS TO AGREEMENT. Section 3.02(iii) is amended by replacing
“November 1, 2005,” with
“February 1,
2006.”

     SECTION 5. COUNTERPARTS. This Second Amendment may be executed in any number of
counterparts, each of which shall be deemed an original, but all of which together shall constitute
one and the same instrument.

     IN WITNESS WHEREOF, the parties hereto have executed this Second Amendment as of date first
above written.

	 	 	 	 	 	 	 	 	 
	CORNERSTONE PHARMACEUTICALS
LTD.	 	 	 	VINTAGE PHARMACEUTICALS, LLC
	 
	 	 	 	 	 	 	 	 
	By:

	 	/s/ Craig A. Collard
	 	 	 	By:
	 	/s/ William S. Propst, Jr.
	 

	 	 
	 	 	 	 	 	 
	Name:

	 	Craig A. Collard
	 	 	 	Name:
	 	William S. Propst, Jr.
	Its:

	 	CEO
	 	 	 	Its:
	 	Presidentexv10w22

Exhibit 10.22

SECOND AMENDMENT TO

ASSET PURCHASE AGREEMENT

     This
Second Amendment to Asset Purchase Agreement (this “Amendment”), is entered into as of
November 13th, 2006 by and between Cornerstone BioPharma, Inc., a Nevada corporation
(“Cornerstone”), and Vintage Pharmaceuticals, LLC, a Delaware limited liability company
(“Vintage”).

     WHEREAS: Cornerstone and Vintage have previously entered into that certain Asset Purchase
Agreement dated as of July 20, 2004, as amended by that certain First Amendment to Asset Purchase
Agreement dated as of May 20, 2005 (together, the
“Agreement”).

     WHEREAS: Section 7.08 of the Agreement provides that Cornerstone must use “commercially
reasonable efforts” to market, produce and sell the Products.

     WHEREAS: Cornerstone and Vintage wish to enter into this Amendment in order to amend Section
7.08 of the Agreement in order to redefine the term “commercially reasonable efforts”.

     NOW, THEREFORE, in consideration of the foregoing and of the mutual covenants, terms and
conditions herein contained, the parties hereto hereby agree as follows:

	1.	 	Defined Terms. Capitalized terms used but not defined herein have the meanings assigned to
them in the Agreement.

	2.	 	Amendment of Section 7.08. Section 7.08 of the Asset Purchase Agreement shall be deleted in
its entirely and replaced with the following:

          “7.08 Marketing of the Products.

     Cornerstone Agrees to use commercially reasonable efforts to market,
promote and sell the Products. “Commercially reasonable efforts” shall
include but not be limited to: (i) Cornerstone’s continued employment of a
minimum of at least thirty (30) sales detail field representatives dedicated
to the sale, promotion and marketing of the Products; (ii) Cornerstone’s
continuous contractual relationship with one or more co-promotion partners
pursuant to which such co-promotion partners will employ at least twenty
(20) sales detail field representatives dedicated to the sale, promotion and
marketing of the Products; (iii) Cornerstone’s use of the Marketing
Materials and development and distribution of other promotional materials;
and (iv) such other marketing and sales methods commonly utilized in the
industry to actively market, promote and sell pharmaceutical products
similar to the Products. Cornerstone shall have until, but no later than,
January 1, 2007 to have a sales force in place that will satisfy the
criteria specified in clauses (i) and (ii) above.”

 

	3.	 	Effect of Amendment. Except as amended herein, all terms and conditions of the Agreement
shall remain in full force and effect, unmodified in any way.

	4.	 	Severability. Each provision of this Amendment shall be interpreted in such manner as to be
effective and valid under applicable law, but if any provision of this Amendment shall be held
lo be prohibited by or invalid under applicable law, such provision shall be ineffective only
to the extent of such prohibition or invalidity, without invalidating the remainder of such
provision or the remaining provisions of this Amendment.

	5.	 	Governing Law. This Amendment shall be governed by and construed in accordance with the laws
of the State of Alabama applicable to contracts executed and performed in such state, without
giving effect to the conflicts of laws principles.

	6.	 	Amendments. This Amendment may be amended, supplemented or modified only by a written
instrument duly executed by each Party.

	7.	 	Counterparts. This Amendment may be executed in any number of counterparts and by facsimile,
each of which will be deemed an original, but all of which together shall constitute one and
the same instrument.

	8.	 	Successors and Assigns. Except as otherwise expressly provided in this Amendment, the
provisions hereof shall inure to the benefit of, and be binding upon, Cornerstone and Vintage
and their respective successors and permitted assigns.

[Remainder of Page Intentionally Left Blank]

 

     IN WITNESS WHEREOF, the parties hereto have executed this Amendment as of the date set forth
above.

	 	 	 	 	 
	 	CORNERSTONE:

CORNERSTONE BIOPHARMA, INC.,

a Nevada corporation

 	 
	 	By:  	/s/ Craig A. Collard
 	 
	 	 	Craig A. Collard, President 	 
	 	 	 	 
	 

	 	 	 	 	 
	 	VINTAGE:

VINTAGE PHARMACEUTICALS, LLC,

a Delaware limited liability company

 	 
	 	By:  	/s/ Tom Young
 	 
	 	Name:  Tom Young 	 
	 	Title:  
CEO 	 
	 

(Second Amendment to Asset Purchase Agreement)exv10w23

Exhibit 10.23

THIRD AMENDMENT TO

ASSET PURCHASE AGREEMENT

     This
Third Amendment to Asset Purchase Agreement (this “Amendment”), is entered into as of
December 7, 2006 by and between Cornerstone BioPharma, Inc., a
Nevada corporation (“Cornerstone”),
and Vintage Pharmaceuticals, LLC, a Delaware limited liability
company (“Vintage”).

     WHEREAS: Cornerstone and Vintage have previously entered into that certain Asset Purchase
Agreement dated as of July 20, 2004, as amended by that certain First Amendment to Asset Purchase
Agreement dated as of May 20, 2005 and by that certain Second Amendment to Asset Purchase Agreement
dated as of November ___, 2006 (together, the
“Agreement”).

     WHEREAS: Under the Agreement, Vintage has the exclusive right to manufacture and market an
authorized generic version of the Product(s); and

     WHEREAS: the parties desire to enable Cornerstone to market and sell an authorized generic
version of the Product(s) directly or by contract with a third party; and

     WHEREAS: Vintage supplies Cornerstone with the Product(s) pursuant to a Manufacturing
Agreement entered into concurrent with the Agreement; and

     WHEREAS: the parties desire for Vintage to manufacture and sell and for Cornerstone to
purchase a generic version of the Product(s) under the Manufacturing Agreement.

     NOW, THEREFORE, in consideration of the foregoing and of the mutual covenants, terms and
conditions herein contained, the parties hereto hereby agree as follows:

	 	1.	 	Defined Terms. Capitalized terms used but not defined herein have the meanings
assigned to them in the Agreement.
	 
	 	2.	 	Amendment of Section 3.05. Section 3.05 of the Asset Purchase Agreement shall
be modified by adding the following subsection (c) after subsection (b):

          ”(c) Vintage grants Cornerstone the right to market and sell an authorized generic
version of the Product(s). Cornerstone may sublicense this right to Aristos Pharmaceuticals,
Inc. Any other sublicense by Cornerstone will require the consent of Vintage, which consent
will not be unreasonably withheld. Sales of such an authorized generic by Cornerstone or its
sublicensee shall be subject to a royalty on Net Sales payable to Vintage as provided in
Section 3.03. During the term of the Manufacturing Agreement, Cornerstone shall purchase and
Vintage shall supply the authorized generic version of Product(s) on the terms and
conditions provided for in the Manufacturing Agreement.”

	3.	 	Effect of Amendment. Except as amended herein, all terms and conditions of the Agreement
shall remain in full force and effect, unmodified in any way.

(Third Amendment to Asset Purchase Agreement)

 

	4.	 	Severability. Each provision of this Amendment shall be interpreted in such manner as to be
effective and valid under applicable law, but if any provision of this Amendment shall be held
to be prohibited by or invalid under applicable law, such provision shall be ineffective only
to the extent of such prohibition or invalidity, without invalidating the remainder of such
provision or the remaining provisions of this Amendment.

	5.	 	Governing Law. This Amendment shall be governed by and construed in accordance with the laws
of the State of Alabama applicable to contracts executed and performed in such state, without
giving effect to the conflicts of laws principles.

	6.	 	Amendments. This Amendment may be amended, supplemented or modified only by a written
instrument duly executed by each Party.

	7.	 	Counterparts. This Amendment may be executed in any number of counterparts and by facsimile,
each of which will be deemed an original, but all of which together shall constitute one and
the same instrument.

	8.	 	Successors and Assigns. Except as otherwise expressly provided in this Amendment, the
provisions hereof shall inure to the benefit of, and be binding upon, Cornerstone and Vintage
and their respective successors and permitted assigns.

     IN WITNESS WHEREOF, the parties hereto have executed this Amendment as of the date set forth
above.

	 	 	 	 	 
	 	CORNERSTONE:

CORNERSTONE BIOPHARMA, INC.,

a Nevada corporation

 	 
	 	By:  	/s/ Craig A. Collard
 	 
	 	 	Craig A. Collard, President 	 
	 	 	 	 
	 

	 	 	 	 	 
	 	VINTAGE:

VINTAGE PHARMACEUTICALS, LLC,

a Delaware limited liability company

 	 
	 	By:  	/s/ Tom Young
 	 
	 	Name:          Tom Young
 	 
	 	Title:  
CEO 	 
	 

(Third Amendment to Asset Purchase Agreement)

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