Document:

Third Amendment dated December 13, 2007, to Lease Agreement

 Exhibit 10.258 
 THIRD AMENDMENT TO LEASE AGREEMENT 
 THIS THIRD AMENDMENT TO LEASE AGREEMENT (this
“Amendment”) is entered into effective as of December 13, 2007, by and between NNN MET CENTER 10, LLC (as successor-in-interest to Met Center Partners-6, Ltd.) (“Landlord”) acting by and through Triple Net Properties Realty,
Inc. (“Agent”) for Landlord, PPD DEVELOPMENT, LP (“Tenant”) and PHARMACEUTICAL PRODUCT DEVELOPMENT, INC. (“Guarantor”). 
 WITNESSETH: 
 WHEREAS, Landlord and Tenant entered into that certain Industrial/Warehouse Lease Agreement
dated effective June 18, 2004 (as amended by that First Amendment To Lease Agreement and that Second Amendment To Lease Agreement, the “Lease”), pertaining to the lease of certain premises located in Travis County, Texas, consisting
of approximately 211,269 gross square feet of space in Building Ten in the MetCenter development (the “Project”); 
 WHEREAS,
Tenant desires to lease and demise from Landlord, and Landlord desires to lease and demise to Tenant, certain additional space in the Building in accordance with the terms and provisions hereinafter provided. 
 NOW, THEREFORE, for and in consideration of the premises and mutual covenants herein contained and other good and valuable consideration, the receipt and
sufficiency of which is hereby acknowledged, the parties hereby agree as follows: 
 1.
2nd Expansion Space. Landlord hereby leases and demises to Tenant the area (the “2nd Expansion Space”) containing approximately 13,710 gross square feet of space on the first floor of the Building, the 2nd Expansion Space being more particularly described in Exhibit A attached hereto, for a term commencing on March 1, 2008 (the “2nd Expansion Space Commencement Date”) and continuing until the Expiration Date (June 30, 2015). The 2nd Expansion Space shall, for all purposes, be deemed to be included within the term “Leased Premises” as used in the Lease and shall be subject in all respects to the terms, provisions and conditions set
forth therein; provided, however, that the 2nd Expansion Space hereby demised to Tenant is accepted by Tenant in an “AS-IS, WHERE-IS”
condition. Notwithstanding the foregoing, Landlord shall use commercially reasonable efforts to cause the current occupant of the 2nd Expansion
Space, the Texas Parks & Wildlife Department, to vacate and surrender the 2nd Expansion Space prior to March 1, 2008 (the date of
expiration of the Texas Parks & Wildlife Department lease). In the event the Texas Parks & Wildlife Department vacates and surrenders the 2nd Expansion Space prior to March 1, 2008, Landlord shall deliver the 2nd Expansion Space to Tenant on the first
(1st) business day following the date upon which the Texas Parks & Wildlife Department vacates and surrenders the 2nd Expansion Space to Landlord and such date of delivery to Tenant shall be deemed to be the 2nd Expansion Space Commencement Date; but only so long as (i) Landlord has given Tenant at least thirty (30) days prior written notice of such earlier 2nd Expansion Space Commencement Date and (ii) such earlier 2nd Expansion Space Commencement Date does not occur prior to February 1, 2008. 

 2. Base Rent. Notwithstanding anything to
the contrary in the Lease, Landlord and Tenant hereby agree that, as of the 2nd Expansion Space Commencement Date, the Base Rent applicable to the 2
nd Expansion Space shall be as follows: 
  

								
	 Period
	  	Monthly Base Rent	  	Annual Base Rent	 
	 03/01/08 - 10/31/08
	  	$	10,853.75	  	$	130,245.00	1
	 11/01/08 - 10/31/09
	  	$	11,425.00	  	$	137,100.00	2
	 11/01/09 - 10/31/10
	  	$	11,996.25	  	$	143,955.00	3
	 11/01/10 - 10/31/11
	  	$	12,567.50	  	$	150,810.00	4
	 11/01/11 - 10/31/12
	  	$	13,138.75	  	$	157,665.00	5
	 11/01/12 - 10/31/13
	  	$	13,710.00	  	$	164,520.00	6
	 11/01/13 - 10/31/14
	  	$	14,281.25	  	$	171,375.00	7
	 11/01/14 - 06/30/15
	  	$	14,852.50	  	$	178,230.00	8

  

	 1
	 (being $9.50 multiplied by the approximate number of total
13,710 gross square feet of the total second Expansion Space) 

	 2
	 (being $10.00 multiplied by the approximate number of total
13,710 gross square feet of the total second Expansion Space) 

	 3
	 (being $10.50 multiplied by the approximate number of total
13,710 gross square feet of the total second Expansion Space) 

	 4
	 (being $11.00 multiplied by the approximate number of total
13,710 gross square feet of the total second Expansion Space) 

	 5
	 (being $11.50 multiplied by the approximate number of total
13,710 gross square feet of the total second Expansion Space) 

	 6
	 (being $12.00 multiplied by the approximate number of total
13,710 gross square feet of the total second Expansion Space) 

	 7
	 (being $12.50 multiplied by the approximate number of total
13,710 gross square feet of the total second Expansion Space) 

	 8
	 (being $13.00 multiplied by the approximate number of total
13,710 gross square feet of the total second Expansion Space) 

 Total Base Rent applicable to the 2nd Expansion Space shall be paid in accordance with the terms of the Lease. 
 3. Tenant’s Proportionate Share; Tenant’s Additional Rent. Landlord and Tenant
acknowledge and agree that, as of the 2nd Expansion Space Commencement Date, Tenant’s Proportionate Share shall be increased to 65.10%. On the
2nd Expansion Space Commencement Date, Tenant shall commence to pay Additional Rent for the 2nd Expansion Space in accordance with the terms of the Lease. The square feet in the 2nd Expansion Space has been calculated and is hereby stipulated for all purposes hereof to be as set forth herein, whether the same should be more or less as a result of minor variations. 
 4. Tenant’s Parking. As of the 2nd Expansion Space Commencement Date, the number of parking space for Tenant within the parking lot as shown on Exhibit A attached to the Lease shall be 1,102 parking spaces,
Tenant’s parking being increased by the addition of 46 parking spaces (the 23 reserved spaces formerly used by Texas Parks and Wildlife as depicted on Exhibit A-2 attached to this Amendment and 23 unreserved spaces within the parking lot as
shown on Exhibit A attached to the Lease). 
 5. Broker’s Commissions. Landlord and Tenant each warrant to the other that it has
not dealt with any broker or agent in connection with the negotiation or execution of this 

 
Amendment other than Atlantis Properties and Equis Corporation, whose commissions shall be paid by Landlord pursuant to a separate written agreement. Tenant
and Landlord shall each indemnify the other against all costs, expenses, attorneys’ fees, and other liability for commissions or other compensation claimed by any other broker or agent claiming the same by, through, or under the indemnifying
party. 
 6. Miscellaneous. 
 a. All terms and conditions of the Lease not expressly modified by this Amendment shall remain in full force and effect, and, in the event of any inconsistencies between this Amendment and the terms of the Lease, the terms set forth in this
Amendment shall govern and control. Except as expressly amended hereby, the Lease shall remain in full force and effect as of the date thereof. 
 b. This Amendment may be executed in one or more counterparts which shall be construed together as one document. 
 c. Captions used
herein are for convenience only and are not to be utilized to ascribe any meaning to the contents thereof. Unless defined differently herein or the context clearly requires otherwise, all terms used in this Amendment shall have the meanings ascribed
to them under the Lease. 
 d. This Amendment (i) shall be binding upon and shall inure to the benefit of each of the parties and their
respective successors, assigns, receivers and trustees; (ii) may be modified or amended only by a written agreement executed by each of the parties; and (iii) shall be governed by and construed in accordance with the laws of the State of
Texas. 
 e. Except for the Lease, there are no other agreements, oral or in writing, between Landlord and Tenant with respect to the
Premises 
 f. The Lease is in full force and effect and Tenant is in possession of the Premises. 
 g. To Tenant’s actual knowledge no default exists under the Lease by Landlord. All improvements required to be made by the Landlord under the terms
of the Lease have been satisfactorily completed. Except as expressly set forth in this Amendment, there are no remaining concessions, bonuses, free months’ rental, rebates, or other matters affecting the rental for Tenant. 
 h. To Tenant’s actual knowledge, Tenant has no claim or demand against Landlord. 
 i. Notwithstanding anything stated above, Tenant does not waive any of its rights contained in Section 3.1 (c) of the Lease or the ability to
make any claims against Landlord under such provisions. 
 [SIGNATURE PAGE(S) FOLLOW] 

 [Signature Page for that Third Amendment To Lease Agreement] 
 EXECUTED as of the date first written above. 
  

			
	LANDLORD:
	
	 TRIPLE NET PROPERTIES REALTY, INC.,
 AGENT
FOR LANDLORD

		
	By:	 	 /s/ Ross Crow

	Name:	 	Ross Crow
	Title:	 	Regional Asset Manager
	
	TENANT:
	
	PPD DEVELOPMENT, LP
		
	By:	 	PPD GP, LLC, a Delaware limited liability company, its general partner
		
	By:	 	 /s/ William J. Sharbaugh

	Name:	 	William J. Sharbaugh
	Title:	 	President
	
	GUARANTOR:
	
	PHARMACEUTICAL PRODUCT DEVELOPMENT, INC.
		
	By:	 	 /s/ William J. Sharbaugh

	Name:	 	William J. Sharbaugh
	Title:	 	Chief Operating OfficerSecond Amendment dated January 10, 2008, to Lease Agreement

 Exhibit 10.259 
 SECOND AMENDMENT TO LEASE 
 THIS SECOND AMENDMENT TO LEASE (this “Amendment) is
made and entered into as of November 5, 2007, by and between BRANDYWINE GRANDE C, L.P., a Delaware limited partnership (“Landlord”), and PPD DEVELOPMENT, LP, a Texas limited partnership
(“Tenant”). 
 A. Landlord and Tenant, as successor-in-interest to PPD Development, LLC, are parties to a certain Lease (as
amended, the “Lease”) dated as of July 1, 2001, as amended by a First Amendment to Lease dated as of March 9, 2007, for approximately 81,710 rentable square feet of space (the “Original Premises”) at
2240-2246 Dabney Road, Richmond, Virginia 23230, as more particularly described in the Lease. 
 B. Tenant desires to lease from Landlord,
and Landlord desires to lease to Tenant, certain additional premises known as Suites B and L (the “Suites B and L Premises”) in the Dabney IX building located at 2248 Dabney Road, Richmond, Virginia 23230 (the “Dabney IX
Building”), which additional premises are shown on the location plan attached hereto as Exhibit A. The parties hereby confirm that the Suites B and L Premises are 3,714 rentable square feet of space in the aggregate. 
 C. The portion of the Suites B and L Premises comprising Suite B contains 2,134 rentable square feet and is referred to herein as “Suite
B”. The portion of the Suites B and L Premises comprising Suite L contains 1,580 rentable square feet and is referred to herein as “Suite L”. 
 D. Landlord and Tenant wish to amend the Lease to, among other things, expand the Original Premises to include the Suites B and L Premises upon the terms and conditions set forth herein. 
 NOW, THEREFORE, in consideration of the mutual covenants and agreements contained herein, Landlord and Tenant hereby agree as follows: 
 1. Incorporation of Recitals; Definitions. The recitals set forth above are hereby incorporated herein by reference as if set forth in full in the
body of this Amendment. Capitalized terms used but not otherwise defined in this Amendment shall have the respective meanings given to them in the Lease. 
 2. Premises. 
 (a) Effective on the Suite B Commencement Date (as defined in Section 3(a)
below), as used in the Lease: (i) “Premises” shall mean, collectively, the Original Premises and Suite B; (ii) “Tenant’s Allocated Share” with respect to the Dabney IX Building shall mean 7.07%;
(iii) “Buildings” shall mean collectively the Dabney A-1 Building, the Dabney A-2 Building, the Dabney VII Building, and the Dabney IX Building; (iv) “Project” shall mean the Buildings, the land and all
other improvements located at 2240-2248 Dabney Road, Richmond, Virginia 23230; and (v) “Rentable Area” with respect to the Premises shall mean 83,844, and with respect to the Project shall mean 111,894. 
 (b) Effective on the Suite L Commencement Date (as defined in Section 3(b) below), as used in the Lease: (i) “Premises”
shall mean, collectively, the Original Premises and Suite L; (ii) “Tenant’s Allocated Share” with respect to the Dabney IX Building shall mean 5.23%; (iii) “Buildings” shall mean collectively the
Dabney A-1 Building, the Dabney A-2 Building, the Dabney VII Building, and the Dabney IX Building; (iv) “Project” shall mean the Buildings, the land and all other improvements located at 2240-2248 Dabney Road, Richmond,
Virginia 23230; and (v) “Rentable Area” with respect to the Premises shall mean 83,290, and with respect to the Project shall mean 111,894. 
 (c) Notwithstanding the foregoing, effective on the later of the Suite B Commencement Date and the Suite L Commencement Date, as used in the Lease: (i) “Premises” shall mean, collectively, the
Original Premises, Suite L, and Suite B; (ii) “Tenant’s Allocated Share” with respect to the Dabney IX Building shall mean 12.30%; (iii) “Buildings” shall mean collectively the Dabney A-1 Building,
the Dabney A-2 Building, the Dabney VII Building, and the Dabney IX Building; (iv) “Project” shall mean the Buildings, the land and all other improvements located at 2240-2248 Dabney Road, Richmond, Virginia 23230; and
(v) “Rentable Area” with respect to the Premises shall mean 85,424, and with respect to the Project shall mean 111,894. 

 (d) Tenant acknowledges and agrees that, notwithstanding any provision of the Lease to the contrary,
Landlord shall have no obligation to make any improvements to the Suites B and L Premises in connection with this Amendment, and Tenant accepts them in their current “AS IS” condition. 
 3. Term. 
 (a) The Term for Suite B
shall commence on the date Landlord delivers possession of the Suite B to Tenant (the “Suite B Commencement Date”); provided if Landlord is unable to deliver possession of Suite B to Tenant on any particular date for any reason,
including without limitation the holdover of the current tenant, the Lease as amended hereby shall continue in effect and Landlord shall not be liable to Tenant or any third party for such inability. The Suite B Commencement Date and expiration date
of the Term shall be confirmed by Landlord and Tenant by the execution of a Confirmation of Lease Term (the “COLT”) in the form attached hereto as Exhibit B. If Tenant fails to execute or object to the COLT within ten
(10) business days of its delivery, Landlord’s determination of such dates shall be deemed accepted. 
 (b) The Term for Suite L
shall commence on the date Landlord executes this Amendment and delivers possession of Suite L to Tenant (the “Suite L Commencement Date”). The Suite L Commencement Date and expiration date of the Term shall be confirmed by Landlord
and Tenant by the execution of a Confirmation of Lease Term (the “COLT”) in the form attached hereto as Exhibit B. If Tenant fails to execute or object to the COLT within ten (10) business days of its delivery,
Landlord’s determination of such dates shall be deemed accepted. 
 (c) The Term for the Premises (collectively, the Original Premises
and the Suites B and L Premises) shall terminate on June 30, 2015. 
 4. Fixed Rent. Fixed Rent for Suite B is set forth below,
payable in the monthly installments as set forth below and otherwise in accordance with the terms of the Lease, as amended hereby: 
  

				
	 TIME PERIOD
	  	MONTHLY INSTALLMENTS
	 Suite B Commencement Date - 6/30/08
	  	$	1,155.92
	 7/1/08 - 6/30/09
	  	$	1,184.37
	 7/1/09 - 6/30/10
	  	$	1,214.60
	 7/1/10 - 6/30/11
	  	$	1,244.83
	 7/1/11 - 6/30/12
	  	$	1,276.84
	 7/1/12 - 6/30/13
	  	$	1,308.85
	 7/1/13 - 6/30/14
	  	$	1,340.86
	 7/1/14 - 6/30/15
	  	$	1,374.65

  

 2 

 Fixed Rent for Suite L is set forth below, payable in the monthly installments as set forth below and otherwise in
accordance with the terms of the Lease, as amended hereby: 
  

				
	 TIME PERIOD
	  	MONTHLY INSTALLMENTS
	 Suite L Commencement Date - 6/30/08
	  	$	855.83
	 7/1/08 - 6/30/09
	  	$	876.90
	 7/1/09 - 6/30/10
	  	$	899.28
	 7/1/10 - 6/30/11
	  	$	921.67
	 7/1/11 - 6/30/12
	  	$	945.37
	 7/1/12 - 6/30/13
	  	$	969.07
	 7/1/13 - 6/30/14
	  	$	992.76
	 7/1/14 - 6/30/15
	  	$	1,017.78

 Fixed Rent shall be payable by: (i) check to Landlord at P.O. Box 8538-363, Philadelphia, PA 19171; or
(ii) wire transfer of immediately available funds to the account at Wachovia Bank, NA, at Philadelphia, PA, account no. 2030000359075, ABA wire routing number 031201467 (ACH ARA routing number 031000503), or as otherwise directed in writing by
Landlord to Tenant. 
 5. Landlord’s Notice Address. Landlord’s “Notice Address/Contact” set forth in
Section 1(k) of the Lease is hereby deleted in its entirety and replaced with the following in lieu thereof: 
  

					
	Landlord:	  	Brandywine Grande C, L.P.	  	With a copy to:
		  	c/o Brandywine Realty Trust	  	Brandywine Realty Trust
		  	300 Arboretum Place, Suite 330	  	555 East Lancaster Ave., Suite 100
		  	Richmond, VA 23236	  	Radnor, PA 19087
		  	Attn: William D. Redd	  	Attn: Brad A. Molotsky, General Counsel

 6. Brokerage Commission. Landlord and Tenant each represents and warrants to the other that
such party has had no dealings, negotiations or consultations with respect to the Premises or this transaction with any broker or finder. Each party shall indemnify and hold the other harmless from and against all liability, cost and expense,
including attorney’s fees and court costs, arising out of any misrepresentation or breach of warranty under this Section. 
 7.
OFAC. Tenant represents, warrants and covenants that neither Tenant nor any of its partners, officers, directors, members or shareholders: (i) is listed on the Specially Designated Nationals and Blocked Persons List maintained by the
Office of Foreign Asset Control, Department of the Treasury (“OFAC”) pursuant to Executive Order No. 13224, 66 Fed. Reg. 49079 (Sept. 25, 2001) (“Order”) and all applicable provisions of Title III of the USA
Patriot Act (Public Law No. 107-56 (October 26, 2001)); (ii) is listed on the Denied Persons List and Entity List maintained by the United States Department of Commerce; (iii) is listed on the List of Terrorists and List of Disbarred
Parties maintained by the United States Department of State; (iv) is listed on any list or qualification of “Designated Nationals” as defined in the Cuban Assets Control Regulations 31 C.F.R. Part 515; (v) is listed on any other
publicly available list of terrorists, terrorist organizations or narcotics traffickers maintained by the United States Department of State, the United States Department of Commerce or any other governmental authority or pursuant to the Order, the
rules and regulations of OFAC (including without limitation the Trading with the Enemy Act, 50 U.S.C. App. 1-44; the International Emergency Economic Powers Act, 50 U.S.C. §§ 1701-06; the unrepealed provision of the Iraq Sanctions Act,
Publ.L. No. 101-513; the United Nations Participation Act, 22 U.S.C. § 2349 as-9; The Cuban Democracy Act, 22 U.S.C. §§ 6001-10; The Cuban Liberty and Democratic Solidarity Act, 18 U.S.C. §§ 2332d and 233; and The
Foreign Narcotic Kingpin Designation Act, Publ. L. No. 106-120 and 107-108, all as may be amended from time to time); or any other applicable requirements contained in any enabling legislation or other Executive Orders in respect of the Order
(the Order and such other rules, regulations, legislation or orders are collectively called the “Orders”); (vi) is engaged in 

  

 3 

 
activities prohibited in the Orders; or (vii) has been convicted, pleaded nolo contendere, indicted, arraigned or custodially detained on charges
involving money laundering or predicate crimes to money laundering, drug trafficking, terrorist-related activities or other money laundering predicate crimes or in connection with the Bank Secrecy Act (31 U.S.C. §§ 5311 et seq.). Tenant
shall defend, indemnify, and hold harmless Landlord from and against any and all claims, damages, losses, risks, liabilities, and expenses (including attorney's fees and costs) arising from or related to any breach of the foregoing representation,
warranty and covenant. The breach of this representation, warranty and covenant by Tenant shall be an immediate Event of Default under this Lease without cure. 
 8. Effect of Amendment; Ratification. Landlord and Tenant hereby acknowledge and agree that, except as provided in this Amendment, the Lease has not been modified, amended, canceled, terminated, released,
superseded or otherwise rendered of no force or effect. The Lease as hereby amended is hereby ratified and confirmed by the parties hereto, and every provision, covenant, condition, obligation, right, term and power contained in and under the Lease,
as amended herein, shall continue in full force and effect, affected by this Amendment only to the extent of the amendments and modifications set forth above, and each shall continue to be binding upon and inure to the benefit of the heirs,
executors, administrators, successors and assigns of each party hereto. 
 9. Authority. Each of Landlord and Tenant represents and
warrants to the other that the individual executing this Amendment on such party’s behalf is authorized to do so. 
 [SIGNATURES ON
FOLLOWING PAGE] 
  

 4 

 IN WITNESS WHEREOF, Landlord and Tenant have duly executed this Amendment as of the date first above
written. 
  

							
	WITNESS:	 		 	LANDLORD:
		 		 	BRANDYWINE GRANDE C, L.P.
				
		 		 	By:	 	Brandywine Grande C Corp.,
		 		 		 	its general partner
				
	 /s/ Bridget Shannon
	 		 	By:	 	 /s/ K. Suzanne Stumpl

	Bridget Shannon	 		 	Name:	 	K. Suzanne Stumpl
	Regional Accountant	 		 	Title:	 	Vice President Asset Management
		 		 	Date:	 	January 10, 2008
			
	WITNESS:	 		 	TENANT:
		 		 	PPD DEVELOPMENT, LP
				
	 /s/ Chuck Munn
	 		 	By:	 	 /s/ William J. Sharbaugh

	Chuck Munn	 		 	Name:	 	William J. Sharbaugh
	Assistant General Counsel	 		 	Title:	 	Chief Operating Officer
		 		 	Date:	 	February 19, 2008

  

 5

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