Document:

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                                                                     EXHIBIT 4.1

                      SECOND AMENDMENT TO RIGHTS AGREEMENT

         This SECOND AMENDMENT TO RIGHTS AGREEMENT (this "AMENDMENT") is entered
into as of November 20, 2003 between Gen-Probe Incorporated, a Delaware
corporation (the "COMPANY"), and Mellon Investor Services LLC, a New Jersey
limited liability company, as Rights Agent (the "RIGHTS AGENT"). Capitalized
terms used but not otherwise defined herein shall have the meanings ascribed to
them in the Rights Agreement (as defined below).

         WHEREAS, the Company and the Rights Agent previously entered into the
Rights Agreement dated as of September 16, 2002 between the Company and the
Rights Agent, as amended by the First Amendment to Rights Agreement, dated as of
October 9, 2002 (the "RIGHTS AGREEMENT");

         WHEREAS, pursuant to Section 26 of the Rights Agreement, the Company
and the Rights Agent may from time to time supplement or amend any provision of
the Rights Agreement in accordance with the terms of such Section 26.

         NOW, THEREFORE, in consideration of the foregoing promises and mutual
agreements set forth in this Amendment, the parties hereby amend the Rights
Agreement as follows:

         1.       Section 7.2 of the Rights Agreement is hereby deleted in its
entirety and replaced with the following:

                           7.2 Purchase. The Purchase Price for each one
         one-hundredth of a Preferred Share pursuant to the exercise of a Right
         shall be $300.00, shall be subject to adjustment from time to time as
         provided in Sections 11, 13 and 26, and shall be payable in lawful
         money of the United States of America in accordance with Section 7.3

         2.       Exhibit C (the "SUMMARY OF RIGHTS") to the Rights Agreement is
hereby replaced in its entirety by EXHIBIT C attached hereto.

         3.       This Amendment may be executed in one or more counterparts,
each of which when executed shall be deemed to be an original, including
counterparts transmitted by facsimile, but all of which taken together shall
constitute one and the same agreement.

         4.       This Amendment shall be deemed to be a contract made under the
laws of the State of Delaware and for all purposes shall be governed by and
construed in accordance with the laws of such State applicable to contracts to
be made and performed entirely within such State.

         5.       On and after the date hereof, each reference in the Rights
Agreement to the "Agreement" shall mean the Rights Agreement as amended hereby.
Except as specifically amended above, the Rights Agreement shall remain in full
force and effect and is hereby ratified and confirmed. The execution, delivery
and effectiveness of this Amendment shall not, except as expressly provided
herein, operate as a waiver of any right, power or remedy of any party hereto,
nor constitute a waiver of any provision of the Rights Agreement.

                            [SIGNATURE PAGE FOLLOWS]

                                       1.

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         IN WITNESS WHEREOF, the parties have executed this Amendment as of the
date first written above.

                                         GEN-PROBE INCORPORATED

                                         By: /s/ R. WILLIAM BOWEN
                                            ------------------------------------

                                         Name: R. William Bowen
                                              ----------------------------------

                                         Title: Vice President & General Counsel
                                               ---------------------------------

                                         MELLON INVESTOR SERVICES LLC,
                                         as Rights Agent

                                         By: /s/ RONALD E. LUG
                                            ------------------------------------

                                         Name: Ronald E. Lug
                                              ----------------------------------

                                         Title: Vice President
                                               ---------------------------------

                                       2.

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                                    EXHIBIT C

                 SUMMARY OF RIGHTS TO PURCHASE PREFERRED SHARES
                             GEN-PROBE INCORPORATED

DISTRIBUTION OF RIGHTS:    On September 16, 2002, the Board of Directors of
                           Gen-Probe Incorporated (the "COMPANY") declared a
                           dividend of one preferred share purchase right (a
                           "RIGHT") for each share of common stock, $.0001 par
                           value (the "COMMON SHARES"), of the Company
                           outstanding at the close of business on September 26,
                           2002 (the "RECORD DATE"). As a result of the dividend
                           of one Common Share paid for each outstanding Common
                           Share distributed on September 30, 2003 (and subject
                           to further adjustment), as long as the Rights are
                           attached to the Common Shares, the Company will issue
                           one-half of a Right with each new Common Share so
                           that all such shares will have attached Rights. The
                           Rights are not exercisable until the Distribution
                           Date, which is described below.

RIGHTS AGREEMENT:          The description and terms of the Rights are set forth
                           in a Rights Agreement, dated as of September 16,
                           2002, as the same may be amended from time to time
                           (the "AGREEMENT"), between the Company and Mellon
                           Investor Services LLC, a New Jersey limited liability
                           company, as Rights Agent (the "RIGHTS AGENT").
                           Capitalized terms used herein and not otherwise
                           defined herein shall have the meaning given to such
                           terms in the Agreement.

TRANSFER OF RIGHTS;        The Agreement provides that until the Distribution
RIGHTS CERTIFICATES:       Date or earlier redemption, exchange, termination, or
                           expiration of the Rights, the Rights will be
                           evidenced, with respect to any of the Common Share
                           certificates outstanding as of the Record Date, by
                           such Common Share certificate together with a copy of
                           this Summary of Rights and that the Rights will be
                           transferred with and only with the Common Shares.
                           Until the Distribution Date (or earlier redemption or
                           expiration of the Rights), new Common Share
                           certificates issued after the Close of Business on
                           the Record Date will contain a notation incorporating
                           the Agreement by reference. Until the Distribution
                           Date (or earlier redemption, exchange, termination or
                           expiration of the Rights), the surrender for transfer
                           of any certificates for Common Shares, with or
                           without such notation or a copy of this Summary of
                           Rights, will also constitute the transfer of the
                           Rights associated with the Common Shares represented
                           by such certificate. As soon as practicable following
                           the Distribution Date, separate certificates
                           evidencing the Rights ("RIGHT CERTIFICATES") will be
                           mailed to holders of record of the Common Shares as
                           of the Close of Business on the Distribution Date and
                           such separate Right Certificates alone will evidence
                           the Rights.

                                      C-1.

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DISTRIBUTION DATE:         Rights will separate from the Common Shares and
                           become exercisable upon the earlier to occur of (i)
                           ten (10) days following a public announcement that a
                           person or group of Affiliated or Associated persons
                           (other than an Existing Holder (as defined below),
                           unless and until such time as the Existing Holder
                           becomes the beneficial owner of an additional 2% or
                           more of the Common Shares) has acquired, or obtained
                           the right to acquire, beneficial ownership of 15% or
                           more of the Common Shares (an "ACQUIRING PERSON") or
                           (ii) ten (10) business days (or such later date as
                           may be determined by action of the Board of Directors
                           prior to such time as any person or group of
                           Affiliated persons becomes an Acquiring Person)
                           following the commencement or announcement of an
                           intention to make a tender offer or exchange offer
                           the consummation of which would result in the
                           beneficial ownership by a person or group of 15% or
                           more of the Common Shares (the earlier of (i) and
                           (ii) being called the "DISTRIBUTION DATE"). "EXISTING
                           HOLDER" means Capital Research and Management
                           Company, together with all of its Affiliates and
                           Associates. As described in the Rights Agreement,
                           Rights which are held by or have been held by an
                           Acquiring Person or Associates or Affiliates thereof
                           and certain transferees thereof will become null and
                           void and will no longer be transferable.

PREFERRED STOCK            When exercisable, each Right will entitle the
PURCHASABLE UPON           registered holder to purchase from the Company one
EXERCISE OF RIGHTS:        one-hundredth of a share of Series A Junior
                           Participating Preferred Stock (the "PREFERRED
                           SHARES") at a price of $300.00 per one one-hundredth
                           of a Preferred Share, subject to adjustment (the
                           "PURCHASE PRICE"), unless the "Flip-In" or
                           "Flip-Over" provisions described below are
                           applicable. Because of the nature of the Preferred
                           Share's dividend, liquidation and voting rights, the
                           value of one one-hundredth of a Preferred Share
                           purchasable upon exercise of each Right should
                           approximate the value of one Common Share. For more
                           information about the Preferred Shares, see "Terms of
                           Preferred Shares" below.

FLIP-IN:                   In the event that a Person becomes an Acquiring
                           Person or if the Company were the surviving
                           corporation in a merger with an Acquiring Person or
                           any Affiliate or Associate of an Acquiring Person and
                           the Common Shares were not changed or exchanged, each
                           holder of a Right, other than Rights that are or were
                           acquired or beneficially owned by the Acquiring
                           Person (which Rights will thereafter be null and
                           void), will thereafter have the right to receive,
                           upon exercise, Common Shares having a market value of
                           two times the then-current Purchase Price of the
                           Right.

FLIP-OVER:                 In the event that, after a Person has become an
                           Acquiring Person, the Company were acquired in a
                           merger or other business

                                      C-2.

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                           combination transaction or more than 50% of its
                           assets or earning power were sold, proper provision
                           shall be made so that each holder of a Right shall
                           thereafter have the right to receive, upon the
                           exercise thereof at the then current Purchase Price
                           of the Right, common stock of the acquiring company
                           having a market value at the time of such transaction
                           equal to two times the then current Purchase Price of
                           the Right.

EXCHANGE PROVISION:        At any time after a Person becomes an Acquiring
                           Person and prior to the acquisition of the Company in
                           a merger or other business combination transaction,
                           the sale of more than 50% of the Company's assets or
                           earning power or the acquisition by such Acquiring
                           Person of 50% or more of the outstanding Common
                           Shares, the Board of Directors may cause the Company
                           to exchange the Rights (other than Rights owned by an
                           Acquiring Person which will have become null and
                           void), in whole or in part, for Common Shares equal
                           to the Spread (as defined in the Agreement), subject
                           to adjustment.

REDEMPTION OF THE          The Rights may be redeemed in whole, but not in part,
RIGHTS:                    at a price of $.01 per Right (the "REDEMPTION PRICE")
                           by the Board of Directors at any time prior to the
                           time that a person becomes an Acquiring Person. The
                           redemption of the Rights may be made effective at
                           such time, on such basis and with such conditions as
                           the Board of Directors in its sole discretion may
                           establish. Immediately upon any redemption of the
                           Rights, the right to exercise the Rights will
                           terminate and the only right of the holders of Rights
                           will be to receive the Redemption Price.

EXPIRATION  OF THE         The Rights will expire on September 26, 2012, subject
RIGHTS:                    to the Company's right to extend such date (the
                           "FINAL EXPIRATION DATE"), unless earlier redeemed or
                           exchanged by the Company or terminated.

AMENDMENT OF TERMS OF      Any of the provisions of the Agreement may be amended
THE RIGHTS:                by the Board of Directors of the Company for so long
                           as the Rights are then redeemable, and after the
                           Rights are no longer redeemable, the Company may
                           amend or supplement the Agreement in any manner that
                           does not adversely affect the interests of the
                           holders of the Rights.

VOTING AND OTHER           Until a Right is exercised, the holder thereof, as
RIGHTS:                    such, will have no rights as a stockholder of the
                           Company beyond those as an existing stockholder,
                           including, without limitation, the right to vote or
                           to receive dividends.

ANTI-DILUTION              The Purchase Price payable, and the number of
PROVISIONS:                Preferred Shares or other securities or property
                           issuable, upon exercise of the Rights

                                      C-3.

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                           are subject to adjustment from time to time to
                           prevent dilution (i) in the event of a stock dividend
                           on, or a subdivision, combination or reclassification
                           of the Preferred Shares, (ii) upon the grant to
                           holders of the Preferred Shares of certain rights or
                           warrants to subscribe for or purchase Preferred
                           Shares or convertible securities at less than the
                           current market price of the Preferred Shares or (iii)
                           upon the distribution to holders of the Preferred
                           Shares of evidences of indebtedness, cash, securities
                           or assets (excluding regular periodic cash dividends
                           at a rate not in excess of 125% of the rate of the
                           last regular periodic cash dividend previously paid
                           or, in case regular periodic cash dividends have not
                           previously been paid, at a rate not in excess of 50%
                           of the average net income per share of the Company
                           for the four quarters ended immediately prior to the
                           payment of such dividend, or dividends payable in
                           Preferred Shares (which dividends will be subject to
                           the adjustment described in clause (i) above)) or of
                           subscription rights or warrants (other than those
                           referred to above). No adjustment in the Purchase
                           Price will be required until cumulative adjustments
                           require an adjustment of at least 1% in such Purchase
                           Price. No fractional Preferred Shares or Common
                           Shares will be issued (other than fractions of
                           Preferred Shares which are integral multiples of one
                           one-hundredth of a Preferred Share, which may, at the
                           election of the Company, be evidenced by depository
                           receipts), and in lieu thereof, a payment in cash
                           will be made based on the market price of the
                           Preferred Shares or Common Shares on the last trading
                           date prior to the date of exercise.

TERMS OF PREFERRED         Each Preferred Share purchasable upon exercise of the
SHARES:                    Rights will be entitled, when, as and if declared, to
                           a minimum preferential quarterly dividend payment of
                           $1.00 per share but will be entitled to an aggregate
                           dividend of 100 times the dividend, if any, declared
                           per Common Share. In the event of liquidation,
                           dissolution or winding up of the Company, the holders
                           of the Preferred Shares will be entitled to a minimum
                           preferential liquidation payment of $100 per share
                           (plus any accrued but unpaid dividends) but will be
                           entitled to an aggregate payment of 100 times the
                           payment made per Common Share. Each Preferred Share
                           will have 100 votes and will vote together with the
                           Common Shares. Finally, in the event of any merger,
                           consolidation or other transaction in which Common
                           Shares are exchanged, each Preferred Share will be
                           entitled to receive 100 times the amount received per
                           Common Share. Preferred Shares will not be
                           redeemable. These rights are protected by customary
                           antidilution provisions.

                                      C-4.

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                  A copy of the Agreement has been filed with the Securities and
Exchange Commission as an Exhibit to a Current Report on Form 8-K. A copy of the
Agreement is available free of charge from the Company. This summary description
of the Rights does not purport to be complete and is qualified in its entirety
by reference to the Agreement, which is incorporated herein by reference.

                                      C-5.<PAGE>
                                                                    Exhibit 10.1

                          VOTING AND SUPPORT AGREEMENT

            VOTING AND SUPPORT AGREEMENT, dated as of November 21, 2003 (this
"Agreement"), by and between Eli Lilly and Company, a Delaware corporation
("Parent"), and [__________] ("Stockholder").

                                    W I T N E S S E T H:

            WHEREAS, Parent, Genesis Merger Sub, Inc., a Delaware corporation
("Merger Sub") and Applied Molecular Evolution, Inc., a Delaware corporation
(the "Company"), have entered into an Agreement and Plan of Merger, dated as of
the date hereof (as the same may be amended or supplemented, the "Merger
Agreement"), providing for, among other things, the merger of Merger Sub with
and into the Company (the "Merger"), upon the terms and subject to the
conditions set forth in the Merger Agreement;

            WHEREAS, as of the date hereof, Stockholder beneficially owns
[_____] shares of common stock, par value $0.001 per share ("Company Shares"),
of the Company (such Company Shares, together with any other shares of capital
stock of the Company acquired by Stockholder after the date hereof and during
the term of this Agreement (including through the exercise of any stock options,
warrants or similar instruments), being collectively referred to herein as the
"Subject Shares"); and

            WHEREAS, as a condition to its willingness to enter into the Merger
Agreement, Parent has requested that Stockholder enter into this Agreement
pursuant to which Stockholder shall, among other things, vote all of the Subject
Shares in favor of the proposal to adopt the Merger Agreement;

            NOW, THEREFORE, to induce Parent to enter into, and in consideration
of its entering into, the Merger Agreement, and in consideration of the
representations, warranties, covenants and agreements set forth in this
Agreement, and intending to be legally bound hereby, the parties hereto agree as
follows:

Section 1.  Irrevocable Proxy.

            (a) Stockholder hereby irrevocably grants to, and appoints, Parent
and any individual who shall be designated by Parent, Stockholder's proxy and
attorney-in-fact (with full power of substitution), for and in the name, place
and stead of Stockholder, to vote the Subject Shares, or grant a consent or
approval in respect of the Subject Shares, at any meeting of stockholders of the
Company or at any adjournment thereof or in any other circumstances upon which
their vote, consent or other approval is sought, in the manner contemplated by
Sections 4(a)(i) and 4(a)(ii) hereof.

            (b) Stockholder represents and warrants that any proxies heretofore
given in respect of the Subject Shares are not irrevocable and that any such
proxies are hereby revoked.

            (c) Stockholder understands and acknowledges that Parent is entering
into the Merger Agreement in reliance upon Stockholder's execution and delivery
of this Agreement. STOCKHOLDER HEREBY AFFIRMS THAT THE PROXY SET FORTH IN THIS
SECTION 1 IS COUPLED WITH AN
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INTEREST AND IS IRREVOCABLE UNTIL SUCH TIME AS THIS AGREEMENT TERMINATES IN
ACCORDANCE WITH ITS TERMS AND THAT NO SUBSEQUENT PROXIES WITH RESPECT TO THE
SUBJECT SHARES SHALL BE GIVEN (AND IF GIVEN SHALL NOT BE EFFECTIVE). Stockholder
hereby further affirms that the irrevocable proxy is given in connection with
the execution of the Merger Agreement and that such irrevocable proxy is given
to secure the performance of the duties of Stockholder under this Agreement.
Stockholder hereby ratifies and confirms all that such irrevocable proxy may
lawfully do or cause to be done by virtue hereof. Such irrevocable proxy is
executed and intended to be irrevocable in accordance with the provisions of
Section 212 of the DGCL. The power of attorney granted by Stockholder is a
durable power of attorney and shall survive the dissolution, bankruptcy, death
or incapacity of Stockholder.

            Section 2. Representations and Warranties of Stockholder.
Stockholder hereby represents and warrants to Parent as follows:

            (a) Ownership. Stockholder is the record and beneficial owner of,
and has good, valid and marketable title to [______] Company Shares, free and
clear of any Liens whatsoever, except as created by this Agreement. Stockholder
does not own, of record or beneficially, any shares of capital stock of the
Company other than such Company Shares. Stockholder has the sole right to vote
such Company Shares, and none of such Company Shares is subject to any voting
trust or other agreement, arrangement or restriction with respect to the voting
of such Company Shares, except as contemplated by this Agreement.

            (b) Authority; No Conflict. Stockholder has all requisite power and
authority to enter into this Agreement and to consummate the transactions
contemplated hereby. This Agreement has been duly executed and delivered by
Stockholder and constitutes a valid and binding obligation of Stockholder
enforceable against Stockholder in accordance with its terms except as may be
limited by bankruptcy, insolvency, reorganization, moratorium and similar laws
of general applicability affecting creditors' rights and by general equity
principles. The execution and delivery of this Agreement does not, and the
consummation of the transactions contemplated hereby and compliance with the
terms hereof will not, conflict with, result in any violation of, or constitute
(with or without notice or lapse of time or both) default under, any provision
of any trust agreement, loan or credit agreement, bond, note, mortgage,
indenture, lease, partnership agreement or other contract, agreement,
obligation, commitment, arrangement, understanding, instrument, permit,
concession, franchise or license or any statute, law, ordinance, rule,
regulation, judgment, order, notice or decree applicable to Stockholder or to
any of Stockholder's property or assets.

            (c) No Filings; Consents. No consents or approvals of or filings or
registrations by or with respect to Stockholder with any Governmental Entity are
necessary in connection with (i) the execution and delivery by Stockholder of
this Agreement and (ii) the performance by Stockholder of its obligations under
this Agreement, including the grant of the irrevocable proxy pursuant to Section
1(a) hereof.

                                       2
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            Section 3. Representations and Warranties of Parent. Parent hereby
represents and warrants to Stockholder that Parent has all requisite corporate
power and authority to enter into this Agreement and to consummate the
transactions contemplated hereby. This Agreement has been duly authorized,
executed and delivered by Parent and constitutes a valid and binding obligation
of Parent enforceable against Parent in accordance with its terms except as may
be limited by bankruptcy, insolvency, reorganization, moratorium and similar
laws of general applicability affecting creditors' rights and by general equity
principles. The execution and delivery of this Agreement does not, and the
consummation of the transactions contemplated hereby and compliance with the
terms hereof will not, conflict with, result in any violation of, or constitute
(with or without notice or lapse of time or both) default under, any provisions
of the certificate of incorporation or by-laws of Parent or any trust agreement,
loan or credit agreement, bond, note, mortgage, indenture, lease or other
contract, agreement, obligation, commitment, arrangement, understanding,
instrument, permit, concession, franchise or license or any statute, law,
ordinance, rule, regulation, judgment, order, notice or decree applicable to
Parent or any of Parent's property or assets.

            Section 4. Covenants of Stockholder. Stockholder agrees with Parent
as follows:

            (a) Without in any way limiting Stockholder's right to vote the
Subject Shares in its sole discretion with respect to any other matters that may
be submitted to a stockholder vote, consent or other approval (including by
written consent), at any meeting of the stockholders of the Company called upon
to adopt the Merger Agreement and approve the Merger or at any adjournment
thereof or in any other circumstances upon which a vote, consent or other
approval (including written consent) with respect to the Merger Agreement and
the Merger is sought, Stockholder shall vote (or cause to be voted) the Subject
Shares:

                  (i) in favor of the Merger, the adoption by the stockholders
            of the Company of the Merger Agreement and approval of the other
            transactions contemplated by the Merger Agreement; and

                  (ii) against (x) any Takeover Proposal or any merger agreement
            or merger (other than the Merger Agreement and the Merger),
            consolidation, combination, sale of substantially all of the
            Company's assets, sale or issuance of securities of the Company or
            any of its Subsidiaries, reorganization, joint venture,
            recapitalization, dissolution, liquidation or winding up of or by
            the Company or any of its Subsidiaries and (y) any amendment of the
            Company's certificate of incorporation or by-laws or equivalent
            organizational documents or other proposal or transaction involving
            the Company or any of its Subsidiaries which amendment or other
            proposal or transaction would or could reasonably be expected to
            impede, frustrate, prevent, nullify or result in a breach of any
            representation, warranty or covenant or any other obligation or
            agreement of the Company under or with respect to the Merger, the
            Merger Agreement or any of the transactions contemplated by the
            Merger Agreement or by this Agreement.

            (b) Stockholder agrees not to transfer, sell, assign, exchange,
pledge or otherwise dispose of (including by gift) or encumber any of the
Subject Shares, or to make any

                                       3
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offer or agreement relating thereto, at any time prior to the termination of
this Agreement. Furthermore, Stockholder shall not, except as contemplated by
this Agreement, directly or indirectly, grant any proxies or powers of attorney
with respect to the Subject Shares, deposit the Subject Shares into a voting
trust or enter into a voting agreement or any other arrangement with respect to
the Subject Shares and shall not commit or agree to take any of the foregoing
actions.

            (c) Stockholder shall be deemed to be a Representative at all times
for purposes of Section 6.2 of the Merger Agreement (regardless of whether
Stockholder is in fact a Representative at the relevant time) and shall comply
with the terms of Section 6.2(a) of the Merger Agreement.

            (d) Stockholder hereby waives, and agrees not to exercise or assert,
any appraisal or similar rights under Section 262 of the DGCL or other
applicable law in connection with the Merger.

            Section 5. Further Assurances. Stockholder will, from time to time,
execute and deliver, or cause to be executed and delivered, such additional or
further consents, documents and other instruments as Parent may reasonably
request for the purpose of effectively carrying out the transactions
contemplated by this Agreement.

            Section 6. Certain Events. Stockholder agrees that this Agreement
and the obligations hereunder shall attach to the Subject Shares and shall be
binding upon any person or entity to which legal or beneficial ownership of such
Subject Shares shall pass, whether by operation of law or otherwise, including
the respective successors of Stockholder. In the event of any stock split, stock
dividend, merger, reorganization, recapitalization or other change in the
capital structure of the Company affecting the Company Shares or the acquisition
of additional shares of Company Shares or other voting securities of the Company
by Stockholder (whether by purchase, conversion or otherwise), the number of
Subject Shares shall be adjusted appropriately and this Agreement and the
obligations hereunder shall attach to any additional or decreased shares of
Company Shares or other voting securities of the Company issued to or acquired
or disposed of by Stockholder.

            Section 7. Stockholder Capacity. Stockholder enters into this
Agreement solely in Stockholder's capacity as the record and beneficial owner of
the Subject Shares. If any Stockholder is or becomes during the term hereof a
director or officer of the Company, such Stockholder makes no agreement or
understanding in this Agreement in Stockholder's capacity as such director or
officer. Nothing in this Agreement shall limit or affect any actions taken by
Stockholder in Stockholder's capacity as an officer or director of the Company.

            Section 8. No Ownership Interest. Except as expressly set forth in
this Agreement, nothing contained in this Agreement shall be deemed to vest in
Parent any direct or indirect ownership or incidence of ownership of or with
respect to any Subject Shares. All rights, ownership and economic benefits of
and relating to any Subject Shares shall remain and belong to Stockholder, and
Parent shall not have any authority to exercise any power or authority to
manage, direct, superintend, restrict, regulate, govern or administer any of the
policies or operations of the Company or exercise any power or authority to
direct Stockholder in the voting of any of the Subject Shares, except as
otherwise expressly provided in this Agreement.

                                       4
<PAGE>
            Section 9. Assignment. Neither this Agreement nor any of the rights,
interests or obligations hereunder shall be assigned, in whole or in part
(whether by operation of law or otherwise), by Stockholder, on the one hand,
without the prior written consent of Parent nor by Parent, on the other hand,
without the prior written consent of Stockholder, and any attempt to make any
such assignment without such consent shall be null and void; provided that
Parent may assign, in its sole discretion, any or all of its rights, interests
and obligations hereunder to any direct or indirect wholly owned subsidiary of
Parent. Subject to the preceding sentence, this Agreement will be binding upon,
inure to the benefit of and be enforceable by the parties and their respective
successors and assigns.

            Section 10. Termination. This Agreement shall terminate, and the
provisions hereof shall be of no further force or effect, upon the earlier of
the Effective Time or the termination of the Merger Agreement in accordance with
Article VIII thereof; provided, however, that notwithstanding anything to the
contrary contained in this Agreement, no party hereto shall be relieved of or
released from any liabilities or damages arising out of a willful breach of its
covenants or a willful breach of its representations or warranties contained in
this Agreement prior to the termination of this Agreement.

            Section 11. General Provisions.

            (a) Modification. No supplement, modification or amendment of this
Agreement will be binding unless made in a written instrument that is signed by
all of the parties hereto and that specifically refers to this Agreement.

            (b) Costs and Expenses. All costs and expenses incurred in
connection with this Agreement and the transactions contemplated hereby shall be
paid by the party incurring such expenses.

            (c) Notice. All notices and other communications hereunder shall be
in writing and shall be deemed given upon receipt by the parties. All notices
hereunder shall be delivered to Parent in accordance with Section 9.2 of the
Merger Agreement and to Stockholder at its address set forth on the Company's
stock ledger (or at such other address for a party as shall be specified by like
notice).

            (d) Interpretation. When a reference is made in this Agreement or to
a Section, such reference shall be to a Section of this Agreement unless
otherwise indicated. The headings contained in this Agreement are for reference
purposes only and shall not affect in any way the meaning or interpretation of
this Agreement. This Agreement is the result of the joint efforts of Parent and
Stockholder, and each provision hereof has been subject to the mutual
consultation, negotiation and agreement of the parties and there shall be no
construction against any party based on any presumption of that party's
involvement in the drafting thereof. The words "include", "includes" or
"including" shall be deemed to be followed by the words "without limitation."
The term "ordinary course of business" (or similar terms) shall be deemed to be
followed by the words "consistent with past practice." Terms not defined herein
shall have such meaning as set forth in the Merger Agreement.

                                       5
<PAGE>
            (e) Counterparts. This Agreement may be executed in two or more
counterparts, all of which shall be considered one and the same agreement and
shall become effective when one or more counterparts have been signed by each of
the parties and delivered to the other parties, it being understood that all
parties need not sign the same counterpart.

            (f) Entire Agreement; No Third Party Beneficiaries. This Agreement
(including the documents and the instruments referred to herein) (i) constitutes
the entire agreement and supersedes all prior agreements and understandings,
both written and oral, among the parties with respect to the subject matter
hereof and (ii) is not intended to confer upon any person other than the parties
hereto any rights or remedies hereunder.

            (g) Governing Law. This Agreement shall be governed by and construed
in accordance with the laws of the State of Delaware, without giving effect to
the principles of conflicts of law thereof.

            (h) Enforcement. The parties agree that irreparable damage would
occur in the event that any of the provisions of this Agreement were not
performed in accordance with their specific terms or were otherwise breached. It
is accordingly agreed that the parties shall be entitled to an injunction or
injunctions to prevent breaches of this Agreement and to enforce specifically
the terms and provisions of this Agreement, in addition to any other remedy to
which they are entitled at law or in equity. The parties hereby (i) submit to
the jurisdiction of any federal or state court sitting in the State of Delaware,
(ii) agree not to object to venue in such courts or to claim that such forum is
inconvenient and (iii) agree that notice or the service of process in any
proceeding shall be properly served or delivered if delivered in the manner
contemplated by Section 11(c) hereof. IN ADDITION, EACH OF THE PARTIES HERETO
WAIVES ANY RIGHT TO TRIAL BY JURY WITH RESPECT TO ANY CLAIM OR PROCEEDING
RELATED TO OR ARISING OUT OF THIS AGREEMENT OR ANY OF THE TRANSACTIONS
CONTEMPLATED HEREBY. Without limiting the generality of the foregoing, the
parties hereto expressly agree that the obligations of Stockholder set forth in
Section 4 hereof shall be subject to the foregoing provisions of this Section
11(h).

            (i) Severability. This Agreement shall be deemed severable; the
invalidity or unenforceability of any term or provision of this Agreement shall
not affect the validity or enforceability of the balance of this Agreement or of
any other term hereof, which shall remain in full force and effect. If of any of
the provisions hereof are determined to be invalid or unenforceable, the parties
shall negotiate in good faith to modify this Agreement so as to effect the
original intent of the parties as closely as possible.

                            [SIGNATURE PAGE FOLLOWS]

                                       6
<PAGE>
            IN WITNESS WHEREOF, the parties hereto have caused this Agreement to
be signed as of the date first written above.

                                    ELI LILLY AND COMPANY

                                    By:
                                       ---------------------------------------

                                    [Stockholder]

                                       ---------------------------------------

                          Voting and Support Agreement
                           Counterpart Signature Page

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