Document:

Sixth Amendment to Lease

 EXHIBIT 10.1 
  
 STATE OF NORTH CAROLINA 
  
 SIXTH AMENDMENT TO LEASE 
  
 COUNTY OF DURHAM 
  
 THIS SIXTH AMENDMENT TO LEASE (the “Amendment”) is dated as of the 3rd day of August, 2005 by and between ROYAL CENTER IC, LLC, a Delaware
limited liability company (“Landlord”) [successor-in-interest to Imperial Center Limited Partnership and Imperial Center, a joint venture (collectively, “Imperial”)] and ICAGEN, INC. (“Tenant”). 
  
 STATEMENT OF PURPOSE 
  
 A. Imperial and Tenant entered into a Lease (as amended, the
“Lease”) dated as of December 17, 1992, for the occupancy of 7,009 rentable square feet of space (the “Initial Premises”) in the building known as Royal Center I (the “Building”) at 4222 Emperor Boulevard, Durham
County, North Carolina for an initial term of five (5) years (the “Initial Premises Term”) and subject to the covenants and conditions particularly set forth in said Lease. 
  
 B. Imperial and Tenant entered into a First Amendment of Lease dated August 26, 1996 for additional space in the Building
containing 2,372 rentable square feet (the “Additional Space”) for an initial term of four (4) years (the “Additional Space Term”). 
  
 C. Imperial and Tenant entered into a Second Amendment to Lease dated September 29, 1998 wherein the first renewal option for the Initial Premises was
exercised thereby extending the Initial Premises Term to July 31, 2001. 
  
 D. Imperial and Tenant entered into a Third Amendment to Lease dated July 6, 2000 wherein the Additional Space Extension Term was exercised thereby extending the Additional Space Extension Term to August 14, 2003 and Landlord and Tenant
have previously agreed, by side letter agreement, to extend the Additional Space Extension Term to August 31, 2003. 
  
 E. Landlord and Tenant entered into a Fourth Amendment to Lease dated July 16, 2001 wherein the term of the Lease with respect to the Initial Premises was
extended for a period of five (5) years and is currently scheduled to expire on July 31, 2006. 
  
 F. Landlord and Tenant entered into a Fifth Amendment to Lease dated April 7, 2003 wherein the term of the Lease with respect to the Additional Space was extended for a period of two (2) years and is currently
scheduled to expire on August 31, 2005. 
  
 H. Landlord and Tenant
desire to amend the terms of the Lease to further extend the term of the Lease with respect to the Initial Premises, and to change certain other provisions of the Lease. 
  
 NOW, THEREFORE, in consideration of the premises, covenants and agreements herein contained, and other good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, the parties agree to amend the Lease on the terms set forth below. The capitalized terms used but not defined herein shall have the meanings set forth within the Lease.

 AGREEMENT 
  

1. Initial Premises Term. Effective as of the date hereof, the Initial Premises Term shall be further extended for a period of four (4) years
(the “Third Initial Premises Extension Term”) commencing August 1, 2006 (the “Third Initial Premises Commencement Date”) and expiring at midnight on July 31, 2010. 
  
 2. Minimum Rent. Commencing on the Third Initial Premises Commencement Date and continuing through July 31, 2010,
Tenant shall pay Minimum Rent for the Initial Premises as follows: 
  

										
	 Period

	  	 Minimum Rental per
 rentable square foot:

	  	Monthly Minimum
Rental

	  	Annual Minimum
Rent

	 8/01/06 to 7/31/07
	  	$	7.58	  	$	4,427.35	  	$	53,128.22
	 8/01/07 to 07/31/08
	  	$	7.81	  	$	4,561.69	  	$	54,740.29
	 8/01/08 to 07/31/09
	  	$	8.04	  	$	4,696.03	  	$	56,352.36
	 8/01/09 to 07/31/10
	  	$	8.28	  	$	4,836.21	  	$	58,034.52

  
 Each installment of
Minimum Rent shall be due and payable in advance on or before the first day of each month in accordance with the terms and conditions of the Lease. In addition to Minimum Rent, Tenant shall continue to pay all additional rent accruing under the
Lease, including Tenant’s pro rata share of Tenant Expenses, in accordance with the terms of the Lease throughout the Third Initial Premises Extension Term. 
  
 3. Condition of Initial Premises. Tenant acknowledges that it presently occupies the Initial Premises and that it
shall continue to occupy the Initial Premises during the Third Initial Premises Extension Term in its “as is, where is “ condition without any further improvements thereto by Landlord. 
  
 4. Rent Abatement. Notwithstanding anything contained herein to the
contrary and in consideration for the foregoing extension, Tenant shall have no obligation to pay Minimum Rent or Tenant Expenses with respect to the Initial Premises only for January and February of 2006 as the Minimum Rent and Tenant Expenses
shall be abated with respect to the Initial Premises only for this time period. 
  
 5. Applicability of Lease Terms. Except as otherwise modified herein, the terms of the Lease shall continue to apply to the Initial Premises during the Third Initial Premises Extension Term, and Tenant shall
continue to occupy the Initial Premises in accordance with the terms and conditions of the Lease, which are hereby ratified, confirmed and continued in full force and effect. Nothing contained in this Amendment shall be deemed to impact
Tenant’s lease of the Initial Premises and Tenant shall continue to occupy the Initial Premises in accordance with the terms and conditions of the Lease. 

 IN WITNESS WHEREOF, the parties hereto have caused this Sixth Amendment to Lease to be duly executed as
of the day and year first above written. 
  

			
	LANDLORD:
	
	ROYAL CENTER IC, LLC, a Delaware limited liability company
		
	By:	 	PRINCIPAL REAL ESTATE INVESTORS, LLC, a Delaware limited liability company, its authorized agent
		
	By:	 	 /s/ Richard J. Jacavino

	Name:	 	Richard J. Jacavino
	Title:	 	Senior Asset Manager
	
	“TENANT”
	
	 ICAGEN, INC.
 a North Carolina
corporation

		
	By:	 	 /s/ P. Kay Wagoner

	 	 	President

  
 ATTEST: 
  

	
	 /s/ Robert J. Jakobs

	Assistant Secretary
	
	[CORPORATE SEAL]Exhibit 10.1

 Exhibit 10.1 
  
 AMENDMENT NO. 5 TO 
 SECOND AMENDED AND RESTATED 
 LOAN FUNDING AND SERVICING AGREEMENT 
 (ACS Funding Trust I) 
  
 THIS AMENDMENT NO. 5 TO SECOND AMENDED AND RESTATED LOAN FUNDING AND SERVICING AGREEMENT, dated as of August 3, 2005 (this
“Amendment”), is entered into by and among ACS FUNDING TRUST I, as the borrower (in such capacity, the “Borrower”), AMERICAN CAPITAL STRATEGIES, LTD., as the servicer (in such capacity, the
“Servicer”), VARIABLE FUNDING CAPITAL CORPORATION, as a conduit lender (in such capacity, a “Conduit Lender”), WACHOVIA CAPITAL MARKETS, LLC, as the deal agent (in such capacity, the “Deal Agent”),
JPMORGAN CHASE BANK, N.A. (“JPMorgan Chase Bank”), as an institutional lender (in such capacity, an “Institutional Lender”) and as the swingline lender (in such capacity, the “Swingline Lender”),
CITIGROUP GLOBAL MARKETS REALTY CORP., as an institutional lender (in such capacity, an “Institutional Lender”), YC SUSI TRUST, as a conduit lender (in such capacity, a “Conduit Lender”), BANK OF AMERICA, NATIONAL
ASSOCIATION, as an institutional lender (in such capacity, an “Institutional Lender”) and as the lender agent for YC SUSI TRUST (in such capacity, a “Lender Agent”) and is acknowledged and agreed to by WACHOVIA
BANK, NATIONAL ASSOCIATION, as a hedge counterparty (in such capacity, the “Hedge Counterparty”). Capitalized terms used and not otherwise defined herein shall have the meanings given to such terms in the Agreement (as defined
below). 
  
 R E C I T
A L S 
  
 WHEREAS, the parties
hereto are parties to that certain Second Amended and Restated Loan Funding and Servicing Agreement, dated as of August 10, 2004 (as amended by Amendment No. 1, dated as of August 27, 2004, Amendment No. 2, dated as of November 15, 2004, Amendment
No. 3, dated as of January 28, 2005 and Amendment No. 4, dated as of April 21, 2005, the “Agreement”); 
  
 WHEREAS, the parties hereto desire to amend the Agreement in certain respects as provided herein, pursuant to and in accordance with Section
12.1(a) of the Agreement; 
  
 NOW, THEREFORE, based
upon the above Recitals, the mutual premises and agreements contained herein, and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto, intending to be legally bound, hereby agree as
follows: 
  
 SECTION 1. AMENDMENTS. 
  
 (a) The defined term “Commitment Termination Date” in Section 1.1
of the Agreement is hereby amended to read in its entirety as follows: 

 “Commitment Termination Date”: August 6, 2008, or such later date as the
Deal Agent and each Lender Agent shall notify the Borrower of in writing in accordance with Section 2.1(d). 
  
 (b) The defined term “Termination Date” in Section 1.1 of the Agreement is hereby amended to read in its entirety as follows: 
  
 “Termination Date”: The earliest to occur
of (a) the Business Day designated by the Borrower to the Deal Agent upon at least two Business Days’ prior written notice, (b) the date of the occurrence of a Termination Event pursuant to Section 9.1, (c) August 8, 2006, as the same
may be extended as provided in Section 2.1(d), (d) the date any Liquidity Purchase Agreement shall cease to be in full force and effect, and (e) the second Business Day prior to the Commitment Termination Date. 
  
 (c) The defined term “Permitted Securitization Transaction” in
Section 1.1 of the Agreement is hereby amended to read in its entirety as follows: 
  
 “Permitted Securitization Transaction”: (a) Any financing transaction undertaken by the Borrower or an Affiliate of the
Borrower or the Originator that is secured, directly or indirectly, by the Collateral or any portion thereof or interest therein, including any sale, lease, whole loan sale, asset securitization, secured loan or other transfer or (b) any transfer by
the Borrower to the Originator of Transferred Loans. 
  
 (d)
Section 2.17(a)(ii) of the Agreement is hereby amended to read in its entirety as follows: 
  
 (ii) Any Lien Release Dividend shall only be in connection with a Permitted Securitization Transaction; provided, that, with respect to any Lien Release Dividend relating to a Permitted Securitization Transaction of
the type set forth in clause (b) of the definition thereof, the sum of the Outstanding Loan Balances of all Transferred Loans included in all such Lien Release Dividends during the 12 month period immediately preceding any Lien Release Dividend Date
for such Lien Release Dividend shall not exceed 20% of the highest Aggregate Outstanding Loan Balance of any month during such 12 month period; provided, further, that, the amount of such Transferred Loans consisting of Defaulted
Loans, Charged-Off Loans and Loans subject to a Warranty Event may not exceed 10% (including all such Loans replaced by the Borrower during such period pursuant to Section 2.19(a)); 
  
 The continuing effectiveness of the amendment to Section 2.17(a)(ii) above is conditioned upon receipt of a letter from
Winston & Strawn LLP confirming that their true sale opinion dated August 10, 2004 is correct after giving effect to this Amendment, to be delivered within 30 days of a request from the Deal Agent for such opinion if the Third Amended and
Restated Loan Funding and Servicing Agreement is not executed by August 31, 2005. 
  

 - 2 - 

 SECTION 2. AGREEMENT IN FULL FORCE AND EFFECT AS AMENDED. 
  
 Except as specifically amended hereby, all provisions of the Agreement shall
remain in full force and effect. After this Amendment becomes effective, all references to the Agreement, the “Loan Funding and Servicing Agreement,” “hereof,” “herein,” or words of similar effect referring to the
Agreement shall be deemed to mean the Agreement as amended hereby. This Amendment shall not constitute a novation of the Agreement, but shall constitute an amendment and waiver thereof. This Amendment shall not be deemed to expressly or impliedly
waive, amend or supplement any provision of the Agreement other than as expressly set forth herein. 
  
 SECTION 3. REPRESENTATIONS. 
  
 Each of the Borrower and Servicer represent and warrant as of the date of this Amendment as follows: 
  
 (a) it is duly incorporated or organized, validly existing and in good
standing under the laws of its jurisdiction of incorporation or organization; 
  
 (b) the execution, delivery and performance by it of this Amendment are within its powers, have been duly authorized, and do not contravene (i) its charter, by-laws, or other organizational documents, or (ii) any
Applicable Law; 
  
 (c) no consent, license, permit, approval or
authorization of, or registration, filing or declaration with any governmental authority, is required in connection with the execution, delivery, performance, validity or enforceability of this Amendment by or against it; 
  
 (d) this Amendment has been duly executed and delivered by it; 
  
 (e) this Amendment constitutes its legal, valid and binding obligation
enforceable against it in accordance with its terms, except as enforceability may be limited by applicable bankruptcy, insolvency, reorganization, moratorium or similar laws affecting the enforcement of creditors’ rights generally or by general
principles of equity; 
  
 (f) it is not in default under the
Agreement; and 
  
 (g) there is no Termination Event, Unmatured
Termination Event, or Servicer Termination Event. 
  
 SECTION
4. CONDITIONS TO EFFECTIVENESS. 
  
 The effectiveness
of this Amendment is conditioned upon (i) payment of the outstanding fees and disbursements of Dechert LLP, as counsel to the Deal Agent and (ii) delivery of executed signature pages by all parties hereto to the Deal Agent. 
  

 - 3 - 

 SECTION 5. MISCELLANEOUS. 
  
 (a) This Amendment may be executed in any number of counterparts (including by facsimile), and by the different parties
hereto on the same or separate counterparts, each of which shall be deemed to be an original instrument but all of which together shall constitute one and the same agreement. 
  
 (b) The descriptive headings of the various sections of this Amendment are inserted for convenience of reference only and
shall not be deemed to affect the meaning or construction of any of the provisions hereof. 
  
 (c) This Amendment may not be amended or otherwise modified except as provided in the Agreement. 
  
 (d) The failure or unenforceability of any provision hereof shall not affect the other provisions of this Amendment. 
  
 (e) Whenever the context and construction so require, all words used in the
singular number herein shall be deemed to have been used in the plural, and vice versa, and the masculine gender shall include the feminine and neuter and the neuter shall include the masculine and feminine. 
  
 (f) This Amendment represents the final agreement between the parties and may
not be contradicted by evidence of prior, contemporaneous or subsequent oral agreements between the parties. There are no unwritten oral agreements between the parties. 
  
 (g) THIS AMENDMENT AND THE RIGHTS AND OBLIGATIONS OF THE PARTIES UNDER THIS AMENDMENT SHALL BE GOVERNED BY AND CONSTRUED
AND INTERPRETED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK. 
  
 [Remainder of Page Intentionally Left Blank] 
  

 - 4 - 

 IN WITNESS WHEREOF, the parties have caused this Amendment to be executed by their respective
officers thereunto duly authorized, as of the date first above written. 
  

			
	ACS FUNDING TRUST I, as Borrower
		
	 By:
	 	 /s/ Malon Wilkus

	Name:	 	Malon Wilkus
	Title:	 	Beneficiary Trustee
	
	AMERICAN CAPITAL STRATEGIES, LTD.,
as Servicer
		
	By:	 	 /s/ Thomas A. McHale

	Name:	 	Thomas A. McHale
	 Title:
	 	Vice President

  
 [SIGNATURES
CONTINUED ON FOLLOWING PAGE] 
  
 5th Amendment to 2nd Amended and Restated Loan Funding 
 and Servicing Agreement 

			
	VARIABLE FUNDING CAPITAL CORPORATION, as a Conduit Lender
		
	 By:
	 	 Wachovia Capital Markets, LLC, as
 attorney-in-fact

		
	 By:
	 	 Douglas R. Wilson, Sr.

	 Name:
	 	 Douglas R. Wilson, Sr.

	 Title:
	 	 Vice President

	
	 WACHOVIA CAPITAL MARKETS, LLC,
 as the Deal Agent

		
	 By:
	 	 /s/ Raj Shah

	 Name:
	 	 Raj Shah

	 Title:
	 	 Director

  
 [SIGNATURES
CONTINUED ON FOLLOWING PAGE] 
  
 5th Amendment to 2nd Amended and Restated Loan Funding 
 and Servicing Agreement 

			
	 JPMORGAN CHASE BANK, N.A., as an
 Institutional Lender

		
	 By:
	 	 /s/ Christine Herrick

	 Name:
	 	 Christine Herrick

	 Title:
	 	 Vice President

	
	 JPMORGAN CHASE BANK, N.A., as the
 Swingline Lender

		
	 By:
	 	 /s/ Christine Herrick

	 Name:
	 	 Christine Herrick

	 Title:
	 	 Vice President

  
 [SIGNATURES
CONTINUED ON FOLLOWING PAGE] 
  
 5th Amendment to 2nd Amended and Restated Loan Funding 
 and Servicing Agreement 

			
	 CITIGROUP GLOBAL MARKETS
 REALTY CORP., as an Institutional Lender

		
	 By:
	 	 /s/ Martin N. Lifshutz

	 Name:
	 	 Martin N. Lifshutz

	 Title:
	 	 Vice President

  
 [SIGNATURES
CONTINUED ON FOLLOWING PAGE] 
  
 5th Amendment to 2nd Amended and Restated Loan Funding 
 and Servicing Agreement 

			
	 YC SUSI TRUST, as a Conduit Lender

		
	 By:
	 	BANK OF AMERICA, NATIONAL ASSOCIATION, as Administrative Trustee and SUSI Trustee
		
	 By:
	 	 /s/ Robert R. Wood

	 Name:
	 	 Robert R. Wood

	 Title:
	 	 Principal

	
	 BANK OF AMERICA, NATIONAL
 ASSOCIATION, as a Lender Agent and as an
 Institutional Lender

		
	 By:
	 	 /s/ Robert R. Wood

	 Name:
	 	 Robert R. Wood

	 Title:
	 	 Principal

  
 5th Amendment to 2nd Amended and Restated Loan Funding 
 and Servicing Agreement

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