Document:

Exhibit

 

AMENDED AND RESTATED
REAL ESTATE LICENSE AGREEMENT

This AMENDED AND RESTATED REAL ESTATE LICENSE AGREEMENT (this “License Agreement”) by and between EMC Corporation, a Massachusetts corporation, having a principal place of business at 176 South Street, Hopkinton, Massachusetts 01748 (“EMC”), and VMware, Inc., a Delaware corporation having its principal office at 3401 Hillview Drive, Palo Alto, California 94304 (“VMware”), is made and shall be effective by and between Licensor and Licensee for all purposes as of the 21st day of September, 2015.   

WITNESSETH:

WHEREAS, the Parties hereto entered into that certain Real Estate License Agreement on August 13, 2007 (the “Original Agreement”) pursuant to which the parties set forth the terms and conditions for the licensing of certain real estate space between the Parties; and

WHEREAS, the Parties desire to amend and restate the terms and conditions of the Original Agreement.

NOW THEREFORE, in consideration of the mutual promises contained herein and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Parties agree as follows:

		
	1.
	Defined Terms.  

(a)“Authorized Signatory” shall mean for purposes of executing any Leasing Memorandum, if on behalf of VMware, an employee or contractor with the title of “Director, or more senior within the Real Estate and Workplace group, and, if on behalf of EMC, an employee or contractor with the title of “GEO Lead” or more senior.
(b)“Commencement Date” shall mean the date that the License commenced for the applicable License Area.
(c)“Lease” and “Leases” shall mean the lease agreement(s) between Licensor and the landlord listed therein.
(d)“License Area” shall mean space that Licensor is licensing to Licensee for its use and occupation, each of which is located in the Premises.
(e)“Licensee” shall mean the Party that uses or occupies the License Area as permitted by the Licensor.
(f)“Licensor” shall mean the Party to this License Agreement that owns, leases, subleases or otherwise has rights to the Premises and is providing use or occupancy of the License Area to the other Party.  
(g)“Party” shall mean each of EMC and VMware individually and “Parties” shall mean EMC and VMware together.
(h)“Premises” shall mean the space described in a particular Lease or space that is owned by the Licensor. 
(i)“Subsidiary” of any Party shall mean any corporation, partnership, limited liability company or other organization, whether incorporated or unincorporated, of which  EMC or VMware is or any subsidiary of EMC or VMware, as the case may be, (a) is the general partner or a manager or member of such Party (b)  owns at least 50%of the outstanding equity or voting securities or interests which have by their terms ordinary voting power to elect a majority of the board of directors or others performing similar functions of such corporation or other organization of such Party or (c) directly or indirectly, controls such Party.  For purposes of this License Agreement, (1) VMware and its Subsidiaries shall not be considered Subsidiaries of EMC and (2) Pivotal Software, Inc. and its Subsidiaries shall be considered Subsidiaries of EMC only, and not of VMware.
		
	2.
	License. 

(a)Licensor hereby grants to Licensee and Licensee hereby accepts from Licensor a license (the “License”) to use and occupy the License Areas and rights of access thereto as more particularly set forth in the 

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Leasing Memorandum (as defined in Section 4) for each specific License Area for the License Period (as defined in Section 3).  Any associated rights with respect to the License Area, including such things as signage, parking, etc., shall be governed by the operating principles attached hereto as Appendix A (the “Operating Principles”) and any exceptions to the Operating Principles shall be documented in the Leasing Memorandum for the specific License Area.  
(b)Each Leasing Memorandum shall be executed by an Authorized Signatory of each Party and delivered by each of Licensee and Licensor prior to the use of the particular License Area; provided that, a Leasing Memorandum for any License Area that is already in use as of the date of this License Agreement shall be executed and delivered by an Authorized Signatory of each Party within sixty (60) days after the date of this License Agreement and shall be categorized in accordance with the License Areas defined in Section 2(d) below and as provided on Appendix B and subject to the Operating Principles. 
(c)With respect to each License Area, Licensee agrees that it has or will have inspected the space and is familiar with the License Area and accepts the same and the contents thereof in their “as is” condition as of the respective Commencement Date.  Licensor shall not be required to perform any work or furnish any materials in order to prepare any License Areas for Licensee’s occupancy, unless otherwise agreed upon in the Leasing Memorandum.

(d)The License Areas shall include (i) Commingled Space, (ii) Demised Space, (iii) Pass-Through Space, (iv) Special Commingled Space, and (v) Specialty Space.  “Commingled Space” shall mean a License Area that is occupied by both Licensor and Licensee with no physical segregation by walls.  “Demised Space” shall mean a License Area that is physically segregated by walls or partitions for the purpose of Licensee’s sole and exclusive occupancy.  “Pass-Through Space” shall mean a License Area that Licensor has specifically procured on behalf of Licensee to be occupied or used entirely by Licensee.  “Special Commingled Space” shall mean a License Area that is occupied by both Licensor and Licensee and is agreed upon by the Parties to be “Special Commingled Space” either in Appendix B or in a Leasing Memorandum, which for this type of space must be executed prior to Licensor making any new or additional commitments to third parties with respect to such space.  “Specialty Space” shall mean a License Area that (i) requires a special agreement because the space will not be used for normal office seats but rather for special purpose uses, such as labs, conference rooms, or customer briefing centers or (ii) is for office space that has in excess of 100 seats, which will require its own lease or sublease.  The Parties can agree in a Leasing Memorandum to different terms governing a License Area than as contemplated by Section 2 and Section 3 hereof, and such Leasing Memorandum terms will prevail in the event of a conflict.

(e)Attached hereto as Appendix B is a schedule listing all License Areas, as of the date hereof, categorized by Commingled Space, Demised Space, Pass-Through Space, Special Commingled Space and Specialty Space. 

		
	3.
	License Period.

(a)    The license for each License Area shall commence on the respective Commencement Date and shall expire (subject to sooner termination as hereinafter provided) at 11:59 P.M. on (i) the date that is one (1) day prior to the expiration date of the term of the related Lease covering the related License Area or (ii) the date listed in the Leasing Memorandum, unless earlier terminated in accordance with the terms of this License Agreement (the actual termination date, the “Termination Date”).  The term “License Period” shall mean the period beginning on the Commencement Date and ending on the Termination Date.  The License Period shall be documented in the Leasing Memorandum.  
(b)    Notwithstanding the provisions of Paragraph (a) above, Licensee shall have the right to terminate the License as to a particular License Area as follows:
		
	(i)
	with respect to Commingled Space:

		
	1)
	With 10 or less seats, by delivery to Licensor of written notice delivered not less than three (3) months prior to the desired early termination date as to such Commingled Space;

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	2)
	With 11-20 seats, by delivery to Licensor of written notice delivered not less than six (6) months prior to the desired early termination date as to such Commingled Space; 

		
	3)
	With more than 20 seats, by delivery to Licensor of written notice delivered not less than nine (9) months prior to the desired early termination date as to such Commingled Space; and

		
	(ii)
	with respect to Special Commingled Space, Licensee may terminate by delivery of written notice delivered prior to the desired early termination date as to such License Area; provided that, Licensor shall continue to cross-charge Licensee on a monthly basis for such License Area until the earlier of (1) the date Licensor begins using or occupying any of the License Area; provided that, if Licensor uses or occupies less than the total License Area, the cross-charge to Licensee for any unused or unoccupied portion will continue monthly, (2) the Termination Date listed in the Leasing Memorandum and (3) the date Licensor is able to dispose of the License Area (e.g., by subleasing the License Area or terminating the underlying Lease).  In addition, the Parties may agree to a lump sum lease termination amount that would include a buyout of the term and any restoration costs. 

		
	(iii)
	With respect to Demised Space and Specialty Space, Licensee may terminate by delivery of written notice delivered prior to the desired early termination date as to such License Area; provided that, Licensor shall continue to cross-charge Licensee on a monthly basis for such License Area until the earlier of (1) the date Licensor begins using or occupying any of the License Area; (2) the Termination Date listed in the Leasing Memorandum and (3) the date Licensor is able to dispose of the License Area (e.g., by subleasing the License Area or terminating the underlying Lease).  In addition, the Parties may agree to a lump sum lease termination amount that would include a buyout of the term and any restoration costs. 

		
	(iv)
	With respect to Pass-Through Space, Licensee is obligated through the Termination Date set forth in the Leasing Memorandum, unless the Parties subsequently agree in writing to terms regarding an early termination.

(c)    In the event the term of a Lease covering a License Area shall sooner terminate in accordance with the provisions thereof (e.g., by reason of casualty or condemnation, and the landlord under the Lease shall exercise a right of termination contained in the Lease, or Licensor, as the tenant thereunder shall exercise a right of termination thereunder), the License for such License Area shall automatically terminate on the date that is one (1) day prior to such termination of such Lease and such date shall be the Termination Date.  Licensor shall give Licensee reasonable prior notice of any such early termination, and Licensee shall take all necessary action to vacate the License Area one (1) day prior to the Termination Date.

(d)    Licensor will provide the Licensee with prior written notice of its intent to (i) enter into any amendment to any Lease which will increase Licensee’s financial obligations or have a material adverse effect on Licensee’s occupancy of the related License Area covered thereby or Licensee’s permitted use of such License Area or (ii) early terminate any Lease that contains License Area; provided that, Licensor shall not amend or early terminate any Lease where Licensee has Pass-Through Space, unless Licensor shall have first obtained Licensee’s consent therefor.  Upon receipt of such notice as provided in subsection (i) above, Licensee will be obligated to inform Licensor as soon as reasonably practicable (but, in any event, within thirty (30) days after receiving such notice) whether it intends to continue to occupy the License Area for the Demised Space, Commingled Space, Special Commingled Space or Specialty Space, as the case may be, during any amended term.  If Licensee elects to terminate the License with respect to such License Area it shall comply with the applicable termination provisions of Paragraph (b) above.  If Licensee elects to continue to occupy the License Area, the Parties shall amend the Leasing Memorandum, as appropriate, to reflect any such changes and an Authorized Signatory of each Party shall execute and deliver the same to the other Party. With respect to any early terminations by Licensor under subsection (ii) above, Licensor will provide Licensee with the same notice periods contemplated under Section 3(b) above and Licensee will be obligated to vacate the space one (1) day prior to the termination date of the underlying Lease.  

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	4.
	License Fee. 

 
(a)On a current monthly basis, Licensor shall cross-charge a license fee for each License Area (the “License Fee”) to the applicable cost center of Licensee, which shall be set forth in the Leasing Memorandum; provided that, Licensee may give notice to Licensor of any update to the applicable cost center and Licensor will cross-charge to such cost center beginning on the month following receipt of such notice. 

		
	(i)
	The License Fee for Commingled Space, Special Commingled Space and Demised Space shall be based on actual costs and calculated for each License Area using the same methodology as Licensor uses for its internal cost allocations for such License Area, and such methodology shall be reflected in the respective Leasing Memorandum, in the form attached hereto as Appendix C (the “Leasing Memorandum”); provided, however, in the event of any “Material Change” to a Commingled Space, Special Commingled Space or Demised Space, an Authorized Signatory of each Party will execute and deliver a revised Leasing Memorandum to reflect any such Material Change, which shall be effective upon the execution and delivery of the Leasing Memorandum.  The term “Material Change” means any change of 25% or more in the relevant metric used to calculate the Unit Cost of a License Area (such as headcount, number of seats or number of square feet).  Concurrent with the execution of a new Leasing Memorandum, Licensor will notify Licensee in writing of the estimated Unit Cost and License Fee (as applicable) to be used for such location and provide reasonable back-up for such calculations.  “Unit Cost” shall mean the actual cost per headcount, per seat or per square feet of the License Area for Commingled Space, Special Commingled Space and Demised Space.  Subject to a Material Change, the Unit Cost shall be fixed through the end of each calendar year.  The License Fee for Commingled Space, Special Commingled Space and Demised Space shall be calculated by multiplying the Unit Cost for the applicable License Area by the headcount, square feet, or number of seats, as applicable. 

		
	(ii)
	The License Fee for Specialty Space shall be determined on a case-by-case basis as negotiated between the parties and shall be documented in the Leasing Memorandum or in the case of office space that has in excess of 100 seats, in the separate lease or sublease agreement.  

		
	(iii)
	The License Fee for Pass-Through Space shall be the actual costs paid to the third party as recognized by the Licensor for the related Lease. 

(b)Licensor shall provide Licensee with reasonable details of the cross-charge calculation for each monthly cross-charge.  No later than November 1 of each year, Licensor will provide to Licensee the estimated Unit Cost for each License Area for the upcoming calendar year so that the Licensee may include such costs in that fiscal year’s budget.  

(c)Upon request by the Licensee, but no more than once per quarter, Licensor shall provide Licensee with reports listing the names of Licensee employees or affiliates seated in each License Area and associated billing ratios (employee’s percentage or allocation of the total cost of the relevant License Area) so that the Parties may review and reconcile their records.  Upon request by Licensee, but no more than once per quarter, Licensor will provide Licensee with soft or hard copies of the most recent invoices reflecting the Lease costs for each Pass-Through Space.  Once per calendar year, Licensee or its authorized representative shall have the right, during business hours and with prior written notice, to inspect the books of Licensor at Licensor’s facilities that relate to the calculation of the License Fee, for the purpose of verifying the methodology used and the costs included; provided that, any and all costs associated with such inspection shall be borne by Licensee.  Licensee shall comply with any confidentiality requirements imposed by Licensor in connection with such inspection and receipt of reports (including, but not limited to, the execution and delivery of a confidentiality agreement reasonably acceptable to Licensor).  The Parties shall in good faith attempt to resolve any dispute and, when the Parties so resolve all disputes, any agreed upon adjustment shall be conclusive and binding on the Parties.  Upon final determination of any License Fee, on the last business day of the then current calendar quarter, Licensor and Licensee shall affect any agreed upon cross-charge adjustment as a result of the inspection.

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(d)The License Fee constitutes the entire fee payable by Licensee to Licensor with respect to the License Areas, and Licensee will not owe Licensor any administrative service fee, administrative mark-up or any other fee for the provision of services by its employees in connection with this Agreement, except as otherwise set forth herein or in a Leasing Memorandum.

5.Services.  Licensee acknowledges that in some of locations of the License Areas, a third-party landlord provides services to such locations.  Licensor shall reasonably cooperate with Licensee so as to enable Licensee to obtain such services, but the foregoing shall not require Licensor to institute any action or proceeding against a landlord.  To the extent that any services to a License Area has been supplied directly by Licensor, then Licensor shall continue to provide such services to such License Area during the related License Period and Licensee shall be responsible for its pro rata share of Licensor’s out-of-pocket costs in connection therewith as provided in the Leasing Memorandum.  Licensor shall provide such services to such License Area in substantially the same manner and quality as Licensor has provided the same to the License Area prior to the Commencement Date or in substantially the same manner and quality as Licensor provides such services to itself.  To the extent permissible, Licensor hereby grants to Licensee the right to receive all of the services and benefits with respect to the License Areas which are to be provided by the related landlord under the Leases.  Notwithstanding the foregoing, although the Parties contemplate that the landlords will, in fact, perform their obligations under the Leases, but, in the event of any default or failure of such performance by any of the landlords, Licensor will, upon the specific written request of Licensee, make demand upon such landlord(s) to perform its obligations under the related Lease.

6.Uses.  Licensee shall only use and occupy a License Area as a permitted use under the related Lease and for no other purpose except (and only to the extent permitted under the terms of the related Lease) as may be reasonably agreed upon in writing by Licensor and Licensee and set forth in the Leasing Memorandum.  

7.Compliance with Law; Observance of Lease Provisions.

(a)To the extent required of Licensor under the related Lease, Licensee’s manner of use of the License Area shall comply with all applicable laws and regulations of all state, Federal, municipal and local governments, departments, commissions and boards and any direction of any public officer pursuant to law, and all orders, rules and regulations of any Board of Fire Underwriters or any similar body having jurisdiction (all of the foregoing being hereinafter collectively referred to as “Laws”).  Notwithstanding the foregoing, Licensee shall have no obligation to expend any funds to correct or change any system or structural element of the License Area so as to comply with any Laws, except as provided herein, in the Lease or as required as a result of Licensee’s specific use of the License Area, which shall be set forth in the Leasing Memorandum.

(b)To the extent required under a related Lease, Licensor shall obtain the consent of the related landlord for Licensee to license the related License Area.  Licensor shall promptly be reimbursed by Licensee for any actual costs incurred by Licensor in obtaining such consent from the landlord.

(c)Licensee shall not violate applicable provisions of any Lease governing the manner of use of the related License Area, the use of building elevators, building common areas, and similar provisions, so as not to cause a default thereunder.

(d)This License Agreement is subject to, and Licensee accepts each License Area is subject to, all the terms, covenants, provisions, conditions and agreements contained in each respective Lease and the matters to which the related landlords are subject and subordinate, all of which are made a part of this License Agreement as though fully set forth herein, except to the extent the same are modified or amendment by this License Agreement or a Leasing Memorandum, it being understood and agreed that said provisions shall fix the obligations of Licensee as if Licensee were the tenant named therein.  Licensee’s rights, however, shall be governed by the terms of this License Agreement.  This License Agreement shall also be subject to, and Licensee accepts this License Agreement is also subject to, any amendments and supplements to the Leases hereafter made between any landlord and Licensor provided that such amendments or supplements comply with the notice obligations in Section 3(d), and where specifically noted therein the prior consent of Licensee.  

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(e)Licensee covenants and agrees (i) to observe and be bound by Licensor’s rules and regulations for any License Area, (ii) that Licensee will not do or cause to be done or suffer or permit its agents or employees to do any act or thing to be done which would or might constitute a default under the Lease and (iii) that any act or omission by Licensee or its agents or employees which constitutes a default under the Lease with respect to the License Area also constitutes a default hereunder.  Licensor covenants and agrees (A) it will not do or cause to be done or suffer or permit any act or thing to be done which would constitute a default under the Lease that would permit the landlord thereunder to cancel or terminate the Lease, (B) will not voluntarily terminate a Lease where Pass-Through Space is located without the prior consent of Licensee and (C) shall deliver to Licensee promptly upon receipt or delivery copies of all default notices under a Lease sent or received by Licensor that relate to License Area.

(f)In the event Licensee is in default under any of the terms of this License Agreement and such default is not cured, Licensor shall have the same rights and remedies against Licensee as are available to the landlord against Licensor pursuant to the Lease for that particular License Area and Licensor shall have the right enter such License Area and cure the same at the sole cost and expense of Licensee.

8.Repairs.  Licensee, throughout the License Period, shall take good care of the License Areas and the fixtures and appurtenances therein as required of the tenant pursuant to the terms of the related Leases.  In the event a particular Lease is silent on Licensor’s obligations to repair, then in addition to Licensee taking good care of the related License Area and the fixtures and appurtenances, Licensee, for that particular License Area, shall also be responsible for the cost to repair any damage caused by Licensee, other than damage from the elements, fire (that is not caused by Licensee) or other casualty to the building of such License Area or damage resulting from ordinary wear and tear.  Licensor shall make, or exercise reasonable efforts to cause to be made by such related landlord responsible for such repairs, all necessary structural and other repairs (for which Licensee is not responsible pursuant to the provisions hereof) to the License Area.

		
	9.
	Damage and Destruction.

(a)Neither Licensor nor Licensee shall have any responsibility to each other in the event of any damage to or theft of any equipment or property of the other Party except if caused by the gross negligence or willful misconduct of such Party, and the Party incurring such loss shall look to its own insurance coverage, if any, for recovery in the event of any such damage, loss or theft. 

(b)If a License Area is destroyed or damaged by fire or other casualty, the License Fee as to such License Area shall abate (entirely if all or substantially all of the License Area is damaged and rendered untenantable and proportionately if only a portion of the License Area is damaged and rendered untenantable, in both cases only to the extent that Licensor’s rent under the Lease is also abated) from the date of the casualty to the date by which (as provided in the Lease covering the License Area) the related landlord or Licensor shall have repaired and restored the License Area or damaged portion thereof (but not Licensee’s property and equipment therein) to substantially the same condition it was in prior to the occurrence of such casualty.  If the casualty or damage occasioned to the License Area or to the Premises of which the damaged License Area forms a part shall be so extensive as to entitle either or both of the landlord and Licensor to terminate the Lease, and either such landlord or Licensor shall terminate the Lease therefor in accordance with the terms thereof, then the License with respect to such License Area shall automatically terminate on the Lease termination date and such date shall be deemed the Termination Date in accordance with Section 3(c).

(c)In the event of the occurrence of a casualty or condemnation which affords Licensor a right under the Lease to terminate the Lease by reason of such casualty or condemnation, then, if the License Space is Pass-Through Space, Licensee shall have the exclusive right to determine whether to exercise such right of termination in its sole and absolute discretion, and if such License Space is Demised Space, Commingled Space, Special Commingled Space or Specialty Space, Licensor shall have the exclusive right to determine whether to exercise such right of termination in its sole and absolute discretion.

		
	10.
	Insurance/Indemnity. 

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(a)Insurance.  To the extent carrying such insurance is not Licensor’s responsibility under another agreement between Licensor and Licensee, Licensee shall maintain in full force and effect throughout the related License Period with respect to the related License Area the insurance (other than property insurance as to alterations in the Premises or equipment owned by Licensor in the Premises, which insurance Licensor shall carry) required to be maintained by Licensor under the related Lease.  Upon request by Licensor, if Licensee carries such insurance separate from Licensor, Licensee shall provide evidence of such insurance to Licensor in accordance with the requirements of the related Lease.

(b)Indemnification of Licensor.  Per each License Area, Licensee shall owe the same indemnification obligations to Licensor as set forth in the Lease covering such License Area as if the words “Owner” or “Landlord” and “Tenant “or “Lessee” or words of similar import, wherever the same appear in the related Lease pertaining to indemnification were construed to mean, respectively, “Licensor” and “Licensee”.  To the extent a Lease is silent on the indemnification obligations running from the “Tenant” to “Landlord”, then for that related License Area, Licensee shall indemnify, defend and hold Licensor, and any partner, officer, agent, employee and director of Licensor (the “Licensor Indemnitees”) harmless from and shall defend the Licensor Indemnitees against all claims made or judicial or administrative actions filed which allege that any one of the Licensor Indemnitees is liable to the claimant (other than to the extent caused by or arising from a Licensor Indemnitee’s gross negligence or willful misconduct) by reason of (i) any injury to or death of any person, or damage to or loss of property, or any other thing occurring on or about the License Area or the Premises, or in any manner growing out of, resulting from or connected with the use, condition or occupancy of, the License Area or the Premises, if caused by any act or omission of Licensee or its agents, partners, contractors, employees, permitted assignees, licensees, sublessees, invitees or any other person or entity for whose conduct Licensee is legally responsible, (ii) violation by Licensee of any contract or agreement to which Licensee is a Party in each case affecting the License Area or the occupancy or use thereof by Licensee, (iii) violation of or failure to observe or perform any condition, provision or agreement of this License Agreement or the respective Leasing Memorandum on Licensee’s part to be observed or performed hereunder, and (iv) Licensee’s manner of use and occupancy of the License Area, except to such extent that any such claim arises from the gross negligence or willful misconduct of Licensor.  Licensor shall similarly indemnify, defend and hold Licensee, and any partner, officer, agent, employee and director of Licensee (the “Licensee Indemnitees”) harmless from and shall defend the Licensee Indemnitees against all claims made or judicial or administrative actions filed which allege that any one of the Licensee Indemnitees is liable to the claimant (other than to the extent caused by or arising from a Licensee Indemnitee’s negligence or willful misconduct) by reason of (i) any injury to or death of any person, or damage to or loss of property, or any other thing occurring on or about the Premises, or in any manner growing out of, resulting from or connected with the use, condition or occupancy of, the Premises, if caused by any negligent act or willful misconduct of Licensor or its agents, partners, contractors, employees, permitted assignees, licensees, sublessees, invitees or any other person or entity for whose conduct Licensor is legally responsible (other than Licensee), (ii) violation by Licensor of any contract or agreement to which Licensor is a Party in each case affecting the Premises or the occupancy or use thereof by Licensor and (iii) violation of or failure to observe or perform any condition, provision or agreement of this License Agreement or the respective Leasing Memorandum on Licensor’s part to be observed or performed hereunder.  In addition, and to the extent applicable, if Licensor is the beneficiary of an indemnity or release from the landlord under a Lease, Licensor shall use commercially reasonable efforts to similarly indemnify or release Licensee, to the extent Licensor actually receives the benefit of such indemnity or release.

11.Assignment; Sublicensing.  The License granted hereby is personal to Licensee and shall not be assigned nor shall Licensee sublicense or otherwise permit or suffer the occupancy of any or all License Area(s) by any third party without first obtaining the prior written consent of Licensor and if required by the related Lease, the landlord.  For the avoidance of doubt, consent to assignment of this Agreement will be required in connection with any sale of all or substantially all of the assets of Licensee or change of control of Licensee in any single transaction or series of transactions by virtue of merger, recapitalization, stock sale or distribution, reorganization or otherwise, that results in the purchase or distribution of more than 50% of the outstanding shares of capital stock of Licensee.  Any purported assignment or sublicense in violation of this Section 11 is void and of no force or effect.

12.Alterations; Restoration.  Licensee shall only make alterations and/or restorations subject to the terms and conditions below for the applicable License Area.

		
	(a)
	Commingled Space, Special Commingled Space or Specialty Space.  

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(i)No alterations may be made by Licensee to the License Area without first obtaining (A) the prior written consent of Licensor, which may be withheld in its sole discretion and (B) if required by the related Lease, the prior written consent of the related landlord of such Lease (which Licensor shall request from such landlord).  All such alterations (and any required restorations at the end of the lease) shall be performed by Licensor or its contractors at Licensee’s sole cost and expense.

(ii)Licensor, at the time of giving consent to any alterations by Licensee, shall notify Licensee if any such alterations must be removed and the License Area restored at the expiration or sooner termination of the applicable License Period and such restoration obligations shall be noted in the applicable Leasing Memorandum.

(iii)If Licensor employs facilities personnel at the Commingled Space, Special Commingled Space or Specialty Space, Licensor will reasonably cooperate with Licensee to coordinate such requested alternations.  Any costs associated with making such alterations, including, but limited to, construction or increased operating costs shall be borne solely by Licensee.

		
	(b)
	Demised Space.

(i)Licensee may make any alterations to the License Area to the extent permitted by (and in accordance with) the terms of the related Lease, provided that Licensee obtains the prior written consent thereto of Licensor which shall not be unreasonably withheld, conditioned or delayed.

(ii)In the event Licensee shall desire to make any alterations to the License Area, Licensee shall provide Licensor prior written notice thereof, specifying in Licensee’s notice the scope and location of the desired alteration(s) as necessary to enable Licensor to formulate a judgment as to the effect such alteration(s) would have upon the building and its systems, and Licensor’s use of, and operation within, that portion of the Premises not constituting the License Area (the “Retained Space”).  Subject to approval of the related landlord if required by the related Lease, Licensor hereby consents to the installation of information systems cabling, electrical distribution circuitry and finishes appurtenant thereto; provided that, Licensor may refuse to allow such alteration if in Licensor’s reasonable judgment such alteration would materially adversely affect Licensor’s use of the Retained Space.

(iii)Any costs associated with making such alterations, including, but limited to, construction or increased operating costs and any restoration costs shall be borne solely by Licensee and shall be documented in the applicable Leasing Memorandum.

		
	(c)
	Pass-Through Space.

(i)Licensee may make any alterations to the License Area to the extent permitted by (and in accordance with) the terms of the related Lease, provided that Licensee provides prior written notice thereof to Licensor and to the extent the consent of the landlord to the related Lease is necessary, Licensee shall work with Licensor to have any discussions related to such consent and shall not work directly with the landlord, unless Licensor gives its written consent to do so, and shall in such event, continue to keep Licensor apprised of all discussions with the landlord.

(iv)Any costs associated with making such alterations, including, but limited to, construction or increased operating costs and any restoration costs shall be borne solely by Licensee and shall be documented in the applicable Leasing Memorandum.

(ii)If Licensee requests an assignment or novation with respect to any Pass-Through Space, Licensor will use commercially reasonable efforts to enter into an assignment or novation agreement to assign the Lease to Licensee with respect to such Pass-Through Space, and any cost associated with such assignment or novation shall be cross-charged to Licensee.

13.Default.  If either Party defaults in the performance of any of its obligations hereunder with respect to a License Area or the License Areas and such default continues for more than fifteen (15) days in the case of a 

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monetary default with respect to a License Area, thirty (30) days with respect to any other monetary default hereunder, and thirty (30) days in the case of a nonmonetary default, in all cases after receipt of written notice from the nondefaulting Party (except that if such nonmonetary default cannot be reasonably cured with the exercise of reasonable diligence during said 30-day period, such period shall be extended for reasonable additional time, provided that, the defaulting Party has commenced to cure such default within the 30-day period and proceeds diligently thereafter to effect such cure), the nondefaulting Party shall have the right to terminate the License herein granted with respect to the applicable License Area and pursue any other remedies available at law or in equity, except as limited in Section 14 hereof.  

14.Limitation of Liability.  NOTWITHSTANDING ANYTHING TO THE CONTRARY CONTAINED IN THIS LICENSE AGREEMENT, IN NO EVENT SHALL EITHER PARTY BE LIABLE TO THE OTHER FOR ANY PUNITIVE, CONSEQUENTIAL, INDIRECT (OTHER THAN ATTORNEYS’ FEES) OR SPECIAL DAMAGES, INCLUDING LOSS OF GOODWILL OR LOSS OF PROFITS. 

		
	15.
	Notices.

(a)Any notice, demand or request under this License Agreement shall be in writing, shall be addressed as hereinafter provided and delivered by registered or certified mail (return receipt requested) which is delivered by reputable overnight commercial carrier (e.g., Federal Express) or hand-delivered and shall be deemed effective upon receipt.  Any notice, demand or request by a Party will be addressed as follows:

In the case of EMC:
EMC Corporation
228 South Street
Hopkinton, Massachusetts  01748
Attention: Vice President, Global Real Estate and Facilities
And to:
EMC Corporation
176 South Street
Hopkinton, Massachusetts  01748
Attention:  Office of the General Counsel

In the case of VMware:

VMware, Inc.
3401 Hillview Drive
Palo Alto, California 94304
Attention: Global Real Estate Lease Administration
Email: realestate@vmware.com 

with a copy to Legal Department at legalcorpdev@vmware.com

(b)Rejection or other refusal to accept, or the inability to deliver because of a changed address of which no notice was given, shall be deemed to be receipt of the notice, demand or request sent.

16.Quiet Enjoyment.  Licensor covenants and agrees that, so long as Licensee shall pay the License Fee as and when due and shall otherwise fully, faithfully and timely observe and perform within applicable notice and cure periods the agreements, covenants and conditions of this License Agreement on its part to be observed and performed with respect to the related License Area, Licensee shall and may peaceably and quietly have, hold and enjoy the related License Area for the related License Period, as same may be extended, without disturbance, hindrance, ejection or molestation by or from Licensor (subject, however, to the provisions hereof) or anyone claiming by, through or under Licensor.

9

17.Waiver of Claims.  As to the period from and after the Commencement Date, notwithstanding anything to the contrary herein, each Party hereto waives all claims against the other Party, its agents and employees for damage to property sustained by the waiving Party resulting from damage to the License Areas or the Premises, as the case may be, its fixtures or any of the waiving Party’s personal property, or resulting directly or indirectly from any act or omission of the other Party.  This Section 17 shall apply especially, but not exclusively, to damage caused by roof leakage, refrigerators, sprinkling devices, air conditioning apparatus, water, steam, excessive heat or cold, falling plaster, broken glass, sewage, gas, odors or noise, or the bursting or leaking of pipes or plumbing fixtures and shall apply whether any such damage results from the act or omission of Licensor or of any other person, and whether such damage be caused or result from anything above mentioned or referred to, or be of a different nature.  All property belonging to the waiving Party or any occupant of the License Areas or the Premises, as the case may be, shall be there at the risk of the waiving Party or such other occupant only, and the other Party shall not be liable for damage thereto or theft or misappropriation thereof.  The waiving Party (and any such occupant) shall look to any insurance coverage that it may have for recovery of any loss or damage to property that such waiving Party or such occupant may sustain.

18.Surrender.  Prior to the applicable Termination Date or sooner termination of the License with respect to the related License Area, Licensee will clean out any Commingled Space or Special Commingled Space occupied by Licensee.  With respect to Demised Space or Specialty Space, if requested by Licensor installations and alterations that were made by or on behalf of Licensee, ordinary wear and tear, fire and other casualty excepted will be restored to the condition required by such restoration provisions of the related Lease and otherwise comply with the surrender provisions of the Lease to the extent applicable to the License Area.  When not otherwise included in the Leasing Memorandum, Licensor and Licensee will agree on the costs of such restoration and such costs will be cross-charged to Licensee.  Notwithstanding anything to the contrary contained herein, in no event shall Licensee have any obligation to restore a License Area to the condition such space was in on the Commencement Date to the extent such restoration related to an alteration which was made to such space prior to the Commencement  Date.  Licensor will manage and oversee any such restoration project.  With respect to Pass-Through Space, Licensee will be required to comply with the surrender and restoration provisions of the applicable Lease.  

19.Subordination.  The License granted herein is subject and subordinate to all ground and underlying leases affecting the real property of which the License Areas form a part and to all mortgages which may now or hereafter affect such leases or such real property.

20.Warranties.  EXCEPT AS SET FORTH IN THIS LICENSE AGREEMENT, THE PARTIES DO NOT MAKE ANY WARRANTIES, EXPRESS OR IMPLIED, WITH RESPECT TO THIS LICENSE AGREEMENT, INCLUDING THE WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE.

21.Inability To Perform.  Neither Party shall be responsible for delays in the performance of its obligations caused by events beyond that Party’s reasonable control, including, but not limited to, acts of God.

22.Good Faith.  The License Areas are of such configuration and are not of such size as to justify, in either case, in the opinion of the Parties, entering into formal leases and/or subleases covering each License Area.  The Parties have therefore entered into this License Agreement which, the Parties recognize, is not dispositive of all matters and issues that may arise during the License Period with respect to each License Area.  As and when issues and matters arise during the course of the License Period that are not definitively controlled by the provisions of this License Agreement, the Operating Principles, the related Leasing Memorandum or the related lease, the Parties shall act reasonably and in good faith endeavor to adjust and resolve such issues and matters.

23.No Contact With Landlord.  Except as specifically permitted under Sections 12(c) and 30(b) or as otherwise consented to in writing by Licensor, Licensee shall not, directly or indirectly, communicate with or have contact of any kind with any landlord under the Leases with respect to the License Area or landlord services or repairs or maintenance to be provided to the License Area or with regard to the Premises (the only exception to the foregoing being if Licensee shall wish to lease space in a building a part of the Premises is located in) the intention hereof being that any communications or contact regarding any of the foregoing (except with regard to a separate leasing of space in such building by Licensee) shall be made solely to Licensor.

10

24.Landlord’s Responsibilities.  Licensee recognizes that Licensor is not in a position to furnish the services set forth in the Leases; obtain an agreement of nondisturbance, or to perform certain other obligations which are not within the control of Licensor.  If Licensor institutes an enforcement action to compel a landlord under a Lease to perform its obligations with respect not only to the License Area but also with respect to other portions of the Premises, the reasonable costs and expenses of such enforcement action shall be equitably apportioned so that, insofar as can be practically determined, each Party shall bear its allocable share of such costs and expenses.

25.Signage.  Subject to the terms of the related Lease covering the License Area, signage rights for each License Area shall be determined using the Operating Principles.  

26.Parking.  Subject to the terms of the related Lease covering the License Area, parking rights for each License Area shall be determined using the Operating Principles.

		
	27.
	Miscellaneous.

(a)Counterparts.  This License Agreement may be executed in two or more counterparts, each of which will be deemed to be an original, but all of which together will constitute one and the same instrument.

(b)Governing Law.  This License Agreement shall be governed by and construed in accordance with the laws of the Commonwealth of Massachusetts; provided that any dispute related to the underlying lease terms for a particular License Area shall be governed by the governing law of the lease.

(c)Section Headings.  The section titles herein are for convenience only and do not define, limit or construe the contents of such sections.

(d)Appendices.  All Appendices to this License Agreement are hereby made a part hereof as if fully set out herein.

(e)Severability.  If any provision or provisions in this License Agreement is/are found to be in violation of any law or otherwise unenforceable, all other provisions will remain unaffected and in full force and effect.

(f)Site Specific Agreements.  The Parties shall execute or cause their applicable subsidiaries to execute any additional agreements as may be reasonably necessary to effectuate the intent of this License Agreement.

(g)Subsidiaries.  If any of the Premises are leased by a Subsidiary of Licensor, (a) Licensor shall cause its Subsidiary to license the applicable License Area to Licensee or its Subsidiary and to perform all of the requirements of Licensor hereunder as to such Premises, (b) such Subsidiary may exercise the rights of Licensor hereunder as to such Premises and (c) references herein to Licensor shall mean Licensor’s Subsidiary as to such Premises.  In addition, if any of the Premises are currently occupied by a Subsidiary of Licensee, (i) Licensee’s Subsidiary shall have the right to occupy such License Area and exercise the rights of Licensee hereunder as to such Premises, (ii) Licensee shall cause its Subsidiary to perform all of the obligations of Licensee hereunder as to such License Area and (iii) references herein to Licensee shall mean Licensee’s Subsidiary as to such License Area.  To the extent Licensor and Licensee deem it necessary and appropriate, such Subsidiaries may enter into real estate license agreements having substantially the same terms as provided in this License Agreement.  Furthermore, if any of the Premises leased by a Subsidiary of Licensor are occupied by employees or other agents acting under the direction and control of Licensee or of a Subsidiary of Licensee and such premises are used by Licensor’s Subsidiary to provide services to Licensee or a Subsidiary of Licensee, (a) Licensor shall cause its Subsidiary to perform all of the obligations of the Licensor hereunder and (b) Licensee shall perform all of the obligations of Licensee hereunder. 

(h)Other.  Time is of the essence with respect to the performance of every provision of this License Agreement in which time of performance is a factor.  When a Party is required to do something by this License Agreement, it shall do so at its sole cost and expense without right of reimbursement from the other Party unless 

11

specific provision is made therefor.  Whenever one Party’s consent or approval is required to be given as a condition to the other Party’s right to take any action pursuant to this License Agreement, unless another standard is expressly set forth, such consent or approval shall not be unreasonably withheld or delayed.  

28.Nonliability.  Licensor and Licensee agree that neither their respective directors, officers, employees, shareholders nor any of their respective agents shall have any personal obligation hereunder, and that Licensor and Licensee shall not seek to assert any claim or enforce any of their rights hereunder against such directors, officers, employees, shareholders or agents.

29.Binding Effect.  This License Agreement shall be binding upon and inure to the benefit of the Parties hereto and their respective successors and permitted assigns, and shall not be modified except by an express written agreement signed by duly authorized representative of both Parties.

30.Cooperation.  The Parties and their respective subsidiaries will cooperate and support each other with respect to future space sharing arrangements.  Without limiting any of the obligations herein, for any new lease, sublease, license or similar agreement between each other, the Parties have decided to memorialize and be bound by the following terms:

(a)The Party entering into a new lease with a landlord, owner, or other third party shall be responsible for paying the security deposit, as applicable, associated with entering into such agreement.

(b)Upon request by Licensee, Licensor will include Licensee in discussions with landlord of a Pass Through Space to negotiate terms of the Lease (including, renewals and amendments).

(c)Approximately twelve (12) months (or such longer period as may be required under a Lease) prior to the expiration of any Lease that has a License Area, Licensor shall notify Licensee of the upcoming expiration date, and Licensee shall, within three (3) months of receiving such notice, notify Licensor whether it desires to continue the License.  The Parties shall cooperate in determining which Party, if any, shall renew such lease.  In the event that Licensor does not intend to renew a Lease that has a License Area, Licensor will provide Licensee with nine months advance notice for Demised Space and with respect to Commingled Space, the same amount of notice as required under Section 3(b).  In the event, Licensor does intend to renew and Licensee has notified Licensor of its desire to continue to License such License Area, an Authorized Signatory on behalf of each Party shall execute and deliver a revised Leasing Memorandum reflecting the new Termination Date. 

(d)If Licensor enters into a lease, sublease, or any similar agreement to use and occupy any Pass-Through Space, Demised Space or, Specialty Space, then Licensee shall reimburse Licensor for all actual out-of-pocket expenses incurred by Licensor in connection with entering into the agreement and complying with the terms thereof, and Licensor will coordinate with Licensee regarding these costs, including providing Licensee an estimate of such costs prior to making any commitments or spending any funds or resources. 

(e)Notwithstanding anything to the contrary herein, neither party will cross charge the other party for internal time spent by its employees related to this Agreement unless agreed to in a signed Leasing Memorandum. 

[Signature Page to the License Agreement Follows Next]

12

IN WITNESS WHEREOF, the Parties hereto have duly executed this Amended and Restated License Agreement as of the day and year first written above.

EMC CORPORATION
By:  /s/ John Herrera    
Name:  John Herrera    
Title:  VP, Global Real Estate    

VMWARE, INC.
By:  /s/ Iris Gai    
Name:  Iris Gai    
Title:  VP, Real Estate & Workplace    

13EX-10.1

 Exhibit 10.1 

MANUFACTURING AND SUPPLY AGREEMENT 

 ***Text Omitted and Filed Separately 

with the Securities and Exchange Commission. 

Confidential Treatment Requested 

Under 17 C.F.R. Sections 200.80(b)(4) 

and 240.24b-2. 

MANUFACTURING AND SUPPLY AGREEMENT 

This MANUFACTURING AND SUPPLY AGREEMENT (this “Agreement”) dated as of July 31, 2015 (the
“Effective Date”) is made by and between Flexion Therapeutics, Inc., a Delaware corporation having its principal place of business at 10 Mall Road, Suite 301, Burlington, Massachusetts, United States (“Flexion”) and
Patheon UK Limited, a company incorporated in England and Wales having its principal place of business at Kingfisher Drive, Covingham, Swindon, SN35BZ, United Kingdom (“Patheon”). Flexion, and Patheon are sometimes referred to
herein individually as a “Party” and collectively as the “Parties.” 
 RECITALS 

WHEREAS, Flexion has a commercial interest in the Manufacture (as defined herein) and commercialization of FX006 drug product, an
extended-release formulation of triamcinolone acetonide (TCA) which is manufactured using the Flexion Manufacturing Process (the “Product”); 

WHEREAS, Patheon has expertise and experience in manufacturing and packaging pharmaceutical products and is interested in providing
Manufacturing services to Flexion in connection with the Product; 
 WHEREAS, in anticipation of this Agreement and the goods and services
that Patheon will supply hereunder, the Parties are executing an agreement pursuant to which Patheon would undertake certain technical transfer and construction services in order to validate and scale up Flexion’s technology package and prepare
Patheon’s facilities for the Manufacture of the Product (the “Technical Transfer Agreement”); and 
 NOW,
THEREFORE, in consideration of the foregoing, the mutual promises and covenants of the Parties contained herein and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Parties hereto,
intending to be legally bound, do hereby agree as follows: 
 ARTICLE I. DEFINITIONS 

The following terms shall have the meanings set forth below. Unless the context indicates otherwise, the singular shall include the plural and
the plural shall include the singular. Any term not defined hereunder shall have the meaning ascribed to such term in the Technical Transfer Agreement. 

1.1 “Additional Services” means any services requested and approved by Flexion that supplement Patheon’s regular
performance of the Services, as described in Schedule 2.1(a). 
 1.2 “Affiliate(s)” means, with respect to any
Person, any other Person that directly, or indirectly through one or more intermediaries, controls, is controlled by, or is under common control with, such Person. For the purposes of this Section 1.2 only, a Person will be regarded as in
control of another Person if such Person owns, or directly or indirectly controls, more than 50% of the voting securities (or comparable equity interests) or other 

 
ownership interests of the other Person, or if such Person directly or indirectly possesses the power to direct or cause the direction of the management or policies of the other Person, whether
through the ownership of voting securities, by contract, or any other means whatsoever. 
 1.3 “Agreed Delivery Date” has
the meaning set forth in Section 2.3(d). 
 1.4 “Agreement” has the meaning set forth in the Preamble hereto. 

1.5 “API” means the active pharmaceutical ingredient Triamcinolone Acetonide, Micronised. 

1.6 “Applicable Law” means applicable United States, Canadian, English and other foreign federal, state, and local laws,
orders, rules, regulations, guidelines, standards, customs and ordinances, including, without limitation, those (to the extent they are applicable) of the FDA, Health Canada, the Medicines and Healthcare Products Regulatory Agency in the United
Kingdom and other comparable foreign Regulatory Authorities, including the FDA Act. 
 1.7 “Base Fee” means the monthly
fee paid by Flexion in consideration for the Services, as more specifically set forth in Schedule 2.1(a) of this Agreement. For the avoidance of doubt, Base Fees do not include Capital Expenditures (as defined in the Technical Transfer
Agreement), Product Fees, Material Costs, or charges for Bill Back Items or Additional Services. 
 1.8 “Bill Back Items”
means the items and services set forth in Schedule 2.1(a) that are used or necessary in connection with the Manufacture of the Products and which result in a nominal cost to Flexion. 

1.8a “Certificate of Analysis” means a certificate evidencing the analytical tests conducted on a specific batch of Product
or Material and setting forth, inter alia, the items tested, specifications, and test results. 
 1.9 “Certificate of
Compliance” means a certificate stating that a specific batch of Product complies with the warranty set forth in Section 6.3. 

1.11 “Change of Control” has the meaning set forth in Section 10.5A. 

1.12 “Claim” has the meaning set forth in Section 9.3(a). 

1.13 “Control” or “Controlled” means ownership or the right by a Party to assign or grant a
license or sublicense under intellectual property rights to the other Party of the scope set forth herein, without breaching the terms of any agreement with a Third Party. 

1.14 “Diligent and Reasonable Steps” has the meaning set forth in Section 6.4(a). 

1.15 “Deficiency Notice” has the meaning set forth in Section 2.8(a). 

  
 - 2 - 

 1.16 “Disclosing Party” has the meaning set forth in Section 1.90. 

1.17 “Discretionary Manufacturing Changes” has the meaning set forth in Section 2.9(c). 

1.18 “Effective Date” has the meaning set forth in the Preamble hereto 

1.19 “EMA” means the European Medicines Agency. 

1.20 “Equipment” means any equipment used in the Manufacture of the Product as more fully set forth in Section 2.9
herein. 
 1.21 “Existing Flexion Intellectual Property” has the meaning set forth in Section 5.1(a). 

1.22 “Existing Patheon Intellectual Property” has the meaning set forth in Section 5.1(b). 

1.23 “Expected Yield Rate” has the meaning set forth in Section 2.8(f). 

1.24 “Expert” has the meaning set forth in Section 2.8(e). 

1.25 “Exploit” means to make, have made, import, use, sell, offer for sale, receive or otherwise dispose of a product or
process, including the research, development (including the conduct of clinical trials), registration, modification, enhancement, improvement, Manufacture, storage, formulation, optimization, export, transport, distribution, promotion, or marketing
of a product or process. 
 1.26 “Facility” means the facility of Patheon located at Kingfisher Drive, Swindon, Wiltshire
SN3 5BZ, United Kingdom, or such other facility approved in accordance with Section 3.3(a). 
 1.27 “FDA” means the
United States Food and Drug Administration and any successor organization thereto and all agencies under its direct control. 
 1.28
“FDA Act” means the Federal Food, Drug, and Cosmetic Act, as amended. 
 1.29 “FDA Approval Date” means
the date of receipt of FDA approval allowing for Patheon’s manufacturing, testing, and packaging for the Product from the Phase I Filling Space and Phase II Manufacturing Space. 

1.30 “Filing Party” has the meaning set forth in Section 3.15(a). 

1.31 “Flexion” has the meaning set forth in the Preamble hereto. 

1.32 “Flexion Assignors” has the meaning set forth in Section 5.1(m). 

  
 - 3 - 

 1.33 “Flexion Improvements” has the meaning set forth in
Section 5.1(e)(ii). 
 1.34 “Flexion Indemnified Parties” has the meaning set forth in Section 9.2. 

1.35 “Flexion Manufacturing Equipment” has the meaning set forth in Section 2.9(a). 

1.36 “Flexion Manufacturing Equipment Improvements” has the meaning set forth in Section 5.1(e)(i). 

1.37 “Flexion’s Manufacturing Process” means the proprietary process owned or Controlled by Flexion for Manufacturing
the Product, as disclosed by Flexion to Patheon, and each intermediate of the Product, as established as of the Effective Date, including without limitation, as set forth in the investigational new drug application filed with the FDA, and, when
applicable, as set forth in the NDA as may be filed with, and approved by, the FDA. 
 1.38 “Flexion’s Manufacturing Process
Improvements” has the meaning set forth in Section 5.1(e)(i). 
 1.39 “Flexion On Site Representative” has
the meaning set forth in Section 3.4. 
 1.40 “Flexion Product Improvements” has the meaning set forth in
Section 5.1(e)(i). 
 1.41 “Flexion Specification Improvements” has the meaning set forth in Section 5.1(e)(i).

 1.41a “Flexion Specific Improvements” has the meaning set forth in Section 5.1(e)(i) 

1.42 “Flexion-Supplied Materials” has the meaning set forth in Section 2.2(a). 

1.43 “Forecast” has the meaning set forth in Section 2.3(a). 

1.44 “GMP” means the current good manufacturing practices applicable from time to time to the Manufacturing of the Product,
or any intermediate of the Product, pursuant to Applicable Law, including those promulgated under the FDA Act at 21 C.F.R. (chapters 210 and 211), and those promulgated under EC Directive 2003/94/EC, together with the latest FDA and EMA guidance
documents pertaining to manufacturing and quality control practice, all as updated, amended and revised from time to time. 
 1.45
“Indemnification Claim Notice” has the meaning set forth in Section 9.3(a). 
 1.46 “Indemnified
Party” has the meaning set forth in Section 9.3(a). 

  
 - 4 - 

 1.47 “Indemnifying Party” has the meaning set forth in Section 9.3(a).

 1.48 “Initial Draft” has the meaning set forth in Section 3.15(b). 

1.49 “Initial Term” has the meaning set forth in Section 8.1. 

1.50 “Key Personnel” has the meaning set forth in Section 2.1(f). 

1.51 “Late Product” has the meaning set forth in Section 2.7(b). 

1.52 “Letter Agreement” means the Letter Agreement between the Parties dated 1 May 2015. 

1.53 “Long Term Forecast” has the meaning set forth in Section 2.3(b). 

1.54 “Loss” means any claims, lawsuits, losses, damages, liabilities, penalties, costs, and expenses (including reasonable
attorneys’ fees and disbursements). 
 1.55 “Maintenance” means the maintenance of Equipment and Facilities in
satisfactory operating condition, including the performance of systematic inspection and service of Equipment pursuant to the applicable Standard Operating Procedures of Patheon, as reviewed and agreed to by Flexion (the “Equipment Standard
Operating Procedures”), or the manufacturer’s terms of operation and recommended procedures. 
 1.56 “Make Good
Costs” has the meaning set forth in Section 8.3(e). 
 1.57 “Manufacture” and “Manufacturing
Services” means the manufacturing, processing, formulating, filling, sterilization, packaging, labelling, storage, handling, and quality control testing of Materials or of the Product. 

1.58 “Manufacturing Suite IOQ” means the completion of the Phase I Filling Space and Phase II Manufacturing
Space, including without limitation, the installation, qualification and operational qualification of the Equipment in each of the Phase I Filling Space and the Phase II Manufacturing Space, including the computer systems, utilities and
manufacturing area enabling the initiations of technical transfer activities, as agreed to by the Parties and indicated by the delivery by Patheon to Flexion of the interim IOQ report for the Phase I Filling Space and Phase II Manufacturing Space.

 1.59 “Manufacturing Services Termination Costs” has the meaning set forth in Section 8.3(g). 

1.60 “Manufacturing Suite” means the manufacturing suite at the Facility capable of Manufacturing the Product pursuant to
Flexion’s Manufacturing Process, whose footprint is set forth in Schedule 1.60, together with the areas identified in the plan attached as Schedule 1.60 as the areas for the bulk powder Manufacture and bulk vial filling, and,
pursuant to the terms of Section 2.10, the Phase I Filling Space. The footprint of the Manufacturing Suite is diagrammatic in nature and is intended to generally depict the location 

  
 - 5 - 

 
and approximate size of current and future spaces allocated to Flexion. Such footprint may be amended during the Term of and pursuant to the Technical Transfer Agreement to be specifically
adapted to the Manufacture of the Product, and the Parties shall agree upon the definitive footprint, taking into account parameters such as the exact design of the space, space classifications, code requirements, equipment, material, personnel,
waste stream process flows, equipment sizing and utility requirements. For purposes of clarity, prior to the Phase III Manufacturing Suite Clearance Date (as defined in Section 2.10 herein), the definition of Manufacturing Suite shall include
the Phase I Filling Space. 
 1.61 “Marketing Authorization” means an approved New Drug Application as defined in the FDA
Act and the regulations promulgated thereunder, or any corresponding foreign application, registration, or certification, necessary or reasonably useful to market any Product in a country or regulatory jurisdiction other than the United States,
including applicable pricing and reimbursement approvals, and all supplements and amendments thereto. 
 1.62 “Materials”
means all API, excipients and processing aids, and processing, filling and packaging components, used in connection with the Manufacture of the Product and listed in Schedule 1.62, as amended prior to Product launch, based on the
Parties’ most recent usage experience rate, and to reflect changes to the Specifications. 
 1.64 “Material
Costs” has the meaning set forth in Section 2.2(a). 
 1.65 “Maximum Manufacturing Services Termination
Costs” has the meaning set forth in Section 8.3(g). 
 1.66 Not used. 

1.67 “NDA” means the new drug application for a product, including the Product, requesting permission to place a drug on the
market in accordance with 21 C.F.R. Part 314, and all supplements filed pursuant to the requirements of the FDA, including all documents, data, and other information filed concerning such product that are necessary for FDA approval to market such
product in the Territory. 
 1.68 “Non-Conforming Product” means (a) a batch of Product that fails, or is aborted
during processing; or (b) a Product Manufactured by Patheon that fails to [...***...]. 
 1.69 “Non-Filing
Party” has the meaning set forth in Section 3.15(a). 
 1.69a “Non-Specific Improvement” has the meaning set
forth in Section 5.1(e)(ii) 
 1.70 “PAI” has the meaning set forth in Section 3.8. 

  
  

***Confidential Treatment Requested 

- 6 - 

 1.71 “Party” and “Parties” have the meanings set forth in the
Preamble hereto. 
 1.72 “Patheon” has the meaning set forth in the Preamble hereto. 

1.73 “Patheon Assignors” has the meaning set forth in Section 5.1(l). 

1.74 “Patheon Improvements” has the meaning set forth in Section 5.1(f)(ii). 

1.75 “Patheon Indemnified Parties” has the meaning set forth in Section 9.1. 

1.76 “Patheon Independent Manufacturing Equipment Improvements” has the meaning set forth in Section 5.1(f)(i). 

1.77 “Patheon Manufacturing Equipment” has the meaning set forth in Section 2.9(a)(ii). 

1.78 “Patheon Non-Applicable Inventions” has the meaning set forth in Section 5.1(f)(ii). 

1.79 “Patheon Nonconformance” has the meaning set forth in Section 2.8(c). 

1.80 “Patheon-Supplied Materials” has the meaning set forth in Section 2.2(a). 

1.81 Not used. 
 1.82
“Person” means an individual, sole proprietorship, partnership, limited partnership, limited liability partnership, corporation, limited liability company, business trust, joint stock company, trust, unincorporated association,
joint venture, or other similar entity or organization, including a government or political subdivision, department, or agency of a government. 

1.83 “Phase I Filling Space”, “Phase II Manufacturing Space” and “Phase III
Manufacturing Suite” shall each be as represented in Schedule 1.60. After the Phase III Manufacturing Suite Clearance Date, the Phase II Manufacturing Space shall be incorporate into the Phase III Manufacturing Suite. 

1.84 “Phase I Filling Space Fee” has the meaning set forth in Schedule 2.1(a) at section II. 

1.85 “Phase III Manufacturing Suite Clearance Date” has the meaning set forth in section 2.10(d). 

1.86 “Phase III Option” has the meaning set forth in section 2.10 (b). 

  
 - 7 - 

 1.87 “Product” has the meaning set forth in the Recitals hereto in finished,
unpackaged form, according to the Specifications, as the same may be amended from time to time. 
 1.88 “Product Fee” has
the meaning set forth in Section 2.4. 
 1.89 “Project Manager” and “Project Managers” have the
meaning set forth in Section 3.4. 
 1.90 “Proprietary Information” means any information disclosed hereunder by one
Party (the “Disclosing Party”) to another Party (the “Receiving Party”) (whether disclosed in oral, written, electronic or visual form) that is non-public, confidential or proprietary including, without limitation,
information relating to the Disclosing Party’s patent and trademark applications, process designs, process models, drawings, plans, designs, data, databases and extracts therefrom, formulae, methods, know-how and other intellectual property,
its clients or client confidential information, finances, marketing, products and processes and all price quotations, manufacturing or professional service proposals and information relating to composition and proprietary technology. In addition,
all analyses, compilations, studies, reports or other documents prepared by any Party’s directors, officers, employees, advisers, agents, consultants, subcontractors, service partners, professional advisors, or representatives (collectively,
“Representatives”) containing the Proprietary Information will be deemed to be Proprietary Information. 
 1.91
“Purchase Order” means a written purchase order that sets forth (a) the quantities of each presentation of Product to be delivered by Patheon to Flexion, (b) the requested delivery dates therefor, and (c) the size of
the vials and bulk packaging to be used for such Product. 
 1.92 “Quality Agreement” has the meaning set forth in
Section 3.1. 
 1.94 “Receiving Party” has the meaning set forth in Section 1.90. 

1.95 “Regulatory Approval” means any and all approvals (including pricing and reimbursement approvals), licenses,
registrations, or authorizations of any Regulatory Authority necessary to Exploit the Product in any country in the Territory, including any (a) approval of a Product, Marketing Authorization and supplements and amendments thereto;
(b) pre- and post-approval marketing authorizations (including any prerequisite Manufacturing approval or authorization related thereto); (c) labelling approval; and (d) technical, medical, and scientific licenses. 

1.96 “Regulatory Authority” means any applicable supra-national, federal, national, regional, state, provincial, or local
regulatory agencies, departments, bureaus, commissions, councils, or other government entities regulating or otherwise exercising authority with respect to the Exploitation of a Product in the Territory. 

1.97 “Regulatory Filings” has the meaning set forth in Section 3.15. 

  
 - 8 - 

 1.98 “Regulatory Obligations” has the meaning set forth in Section 3.15.

 1.99 “Remediation Period” has the meaning set forth in Section 8.2(a)(iii). 

1.100 “Replacement Entity” has the meaning set forth in Section 8.3(f). 

1.101 “Reports” has the meaning set forth in Section 3.11. 

1.102 “Required Manufacturing Changes” has the meaning set forth in Section 2.9(b). 

1.103 “Scheduled Production Date” has the meaning set forth in Section 2.3(d). 

1.104 “Services” means the (a) Manufacturing Services performed by Patheon under this Agreement and (b) the
Transfer Services performed by Patheon pursuant to the Technical Transfer Agreement. 
 1.105 “Shipment Costs” has the
meaning set forth in Section 2.8(c). 
 1.106 “Specifications” means the specifications for each presentation of
Product (i.e., the dosage forms in Schedule 1.82) given by Flexion to Patheon relating to the specifications of the Materials; the manufacturing specifications, directions and processes; the storage requirements; all
environmental, health and safety information for the Product including material safety data sheets and the finished Product specifications, specifications for bulk and primary packaging and shipping requirements for the Product, as amended,
modified, or supplemented from time to time. 
 1.107 “Steering Committee” has the meaning set forth in the Technical
Transfer Agreement. 
 1.108 “Supplies” means various consumables / disposables used in small quantities for gowning,
cleaning of Equipment and Manufacturing Suite, and in quality control testing of Materials and Product. 
 1.109 “Taxes”
means all forms of taxation and statutory, governmental, state, federal, provincial, local, government or municipal charges, duties, imposts, contributions, levies, withholding or liabilities wherever chargeable and whether of the United Kingdom or
any other jurisdiction (including for the avoidance of doubt, national insurance contributions in the United Kingdom) and any penalty, fine, surcharge, interest, charge, charges or costs thereto. 

1.110 “Technical Transfer Agreement” has the meaning set forth in the Recitals. 

1.111 “Term” has the meaning set forth in Section 8.1. 

  
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 1.112 “Territory” means [...***...] and other territories agreed by the
Parties pursuant to Section 2.2(h) from time to time. 
 1.113 “Third Party” means a Person who is
neither a Party nor an Affiliate of a Party. 
 1.114 “Third Party Losses” means Losses incurred as a result
of claims brought by Third Parties. 
 1.115 “Transfer Services” has the meaning set forth in
Section 1.64 of the Technical Transfer Agreement. 
 1.116 “TUPE” has the meaning set forth in
Section 8.3(f). 
 1.117 “VAT” has the meaning set forth in Section 4.4(c). 

1.118 “Yield” has the meaning set forth in Section 2.8(f). 

1.119 “Yield Reimbursement Payment” has the meaning set forth in Section 2.8(f). 

ARTICLE II. MANUFACTURING SERVICES 

2.1 Supply Obligations. 

(a) Subject to the terms and conditions hereof and in consideration for the payments set forth in Schedule 2.1(a),
Patheon shall provide the Manufacturing Services and shall supply the Product [...***...] to Flexion. Flexion agrees to purchase from Patheon such quantities of Product as Flexion may order, in its discretion, in accordance with the terms
herein during the Term. 
 (b) Pursuant to the Technical Transfer Agreement, Flexion will develop and Patheon will confirm
Flexion’s Manufacturing Process. Flexion’s Manufacturing Process is the Proprietary Information of Flexion, as further clarified in Article V. 

(c) Patheon shall Manufacture all Products delivered hereunder (i) in accordance with the Specifications, this Agreement,
the Quality Agreement, and (ii) in compliance with GMP and all other Applicable Law. 
 (d) Patheon shall ensure that
sufficient numbers of adequately educated and experienced staff are retained at the Facility in order to Manufacture evenly throughout the year the volumes of Product set out in the Forecast. Patheon shall perform all activities necessary to
maintain a GMP compliant status of the 

  
  

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manufacturing lines and areas of the Facility applicable to the Manufacture of the Product. 

(e) Flexion reserves the right to request replacement of any personnel assigned by Patheon to perform the Services hereunder.
If Patheon disagrees with such request and the Parties cannot reach resolution on Flexion’s request for replacement, such request will be discussed by the Steering Committee pursuant to the procedures set forth in Exhibit 2.7 of the Technology
Transfer and Services Agreement. 
 (f) Patheon shall perform the Services under the direction of key personnel of Patheon
to a project for the duration of the project (“Key Personnel”). Key Personnel include the Project Manager, Operational Manager, Quality Manager or other personnel reasonably agreed-to by the Parties. Patheon shall provide
information on the qualifications and background of all proposed Key Personnel prior to such Key Personnel’s commencement of activities under this Agreement on Patheon’s behalf. Patheon will not remove Key Personnel without Flexion’s
prior written consent (not to be unreasonably withheld, conditioned or delayed) except in the event of such Key Personnel’s promotion, resignation, incapacity or death, or termination for cause. Patheon will use commercially reasonable
efforts to minimize turnover in Key Personnel, and will provide [...***...] business days’ notice to Flexion, whenever practical, of any changes to the Key Personnel, at which point, both Parties shall discuss and reasonable agree on a
suitable replacement. 
 2.2 Materials, Bill Back Items and Additional Services. 

(a) All Materials necessary for the Manufacture of the Product are set forth in Schedule 1.62. Patheon shall source all
of the Materials set forth on Schedule 1.62 under the heading “Patheon Supplied Materials (“Patheon-Supplied Materials”), and such Materials will be invoiced to Flexion monthly at the time of purchase by Patheon, at cost
plus an [...***...]% handling fee, in accordance with the invoicing procedure set forth in ARTICLE IV (“Material Costs”). Flexion will purchase, and ship to Patheon in accordance with Schedule 1.62 under the heading
“Flexion Supplied Materials” (the “Flexion-Supplied Materials”) unless otherwise agreed to by the Parties. Patheon shall store, handle, and protect the Materials with a reasonable level of care, which shall include taking
all reasonable precautions to ensure that the Materials are not subject to contamination, deterioration, destruction, or theft. Patheon shall keep adequate records of its usage of the Materials during the Term. 

(b) Flexion acknowledges that Patheon is required under GMP to follow certain verification and approval processes for all
vendors used by 

  
  

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Patheon in the procurement of Materials. In the event that Flexion requests Patheon to procure Materials from a vendor that is not currently verified by Patheon, Flexion will be liable for
Patheon’s fees for the performance of the initial audit and verification activities by Patheon under this Section 2.2(b) as an Additional Service. 

(c) Flexion will, at its sole cost and expense, deliver to Patheon the Flexion-Supplied Materials to the Facility DDP
(Incoterms 2010) at no cost to Patheon at least [...***...] days before the Scheduled Production Date, in sufficient quantities for Patheon to Manufacture the desired quantities of Product and to ship Product by the Agreed Delivery Date. If
the Flexion-Supplied Materials are not received [...***...] days before the Scheduled Production Date, Patheon may delay the shipment of Product for a period of time proportionate to such delay. All shipments of Flexion-Supplied Materials, if
required, will be accompanied by Certificate(s) of Analysis from the Material manufacturer or Flexion, confirming its compliance with the Material’s specifications. Flexion will obtain the proper release of the Flexion-Supplied Materials from
the applicable customs agency and/or Regulatory Authority. Flexion or Flexion’s designated broker will be the “Importer of Record” for Flexion-Supplied Materials imported to the Facility. Flexion-Supplied Materials will be held by
Patheon on behalf of Flexion as set forth in this Agreement. Title to Flexion-Supplied Materials will at all times remain the property of Flexion. Any Flexion-Supplied Materials received by Patheon will only be used by Patheon to perform the
Manufacturing Services or associated activities necessary to perform the Manufacturing Services (e.g. media fills or validation runs). 

(d) Flexion and Patheon will agree upon a minimum inventory level of Patheon-Supplied Materials required to support the
Manufacture of the Product based on the last Forecast received by Patheon from Flexion. Patheon will keep on hand all Materials necessary to support the Manufacture of the Product based on such agreed-upon minimum inventory levels. 

(e) Patheon will provide sufficient storage capacity to support storage of the required quantity of Materials pursuant to
Section 2.2 of this Agreement for up to the longer of [...***...] or the amount of time set forth next to the applicable Material on Schedule 1.62 herein. Patheon will also provide sufficient storage capacity to support storage of
Product for up to [...***...] post Manufacture [...***...]. Any additional storage, or storage of Materials (either Flexion-Supplied Materials or Patheon-Supplied Materials) or Product beyond the applicable period stated herein,
will be subject to the mutual agreement of the Parties. For any such additional storage, Flexion will pay Patheon £[...***...] per pallet, per month for storing any Materials or Product. Storage of Materials or Product that
contain controlled substances or require refrigeration will be charged at £[...***...] per pallet per month. Storage fees are subject to a one pallet minimum 

  
  

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charge per month. [...***...] will be liable for all risk or loss of damage to stored Materials or Product to the extent such damage was caused by [...***...]’s, or its
subcontractor’s or vendors’, [...***...]. Patheon shall store the Product according to GMP, any applicable storage guidelines stipulated by Flexion and agreed by Patheon and the provisions under the Quality Agreement. 

(f) Bill Back Items will be charged to Flexion at Patheon’s cost plus a [...***...]% handling fee. Patheon shall
invoice Flexion monthly for any Bill Back Items used in connection with the Manufacture of the Products during the preceding month in accordance with ARTICLE IV. Patheon may only invoice Bill Back Items that have been quoted to and approved in
writing by Flexion’s Project Manager, or otherwise mutually agreed to by the Parties in advance. 
 (g) If Flexion is
interested in having Patheon perform Additional Services, Flexion will provide Patheon with a written request containing sufficient detail to enable Patheon to provide Flexion with a quote and proposal to provide such Additional Services. Patheon
may only invoice for Additional Services that have been quoted to and approved in writing by an authorized person of Flexion and that have been agreed in writing by the Parties in a Change of Scope Agreement. Where a rate for Additional Services has
been specified in Schedule 2.1 (a), such rates are calculated as at 1st January, 2015. These fees will be adjusted on 1st January of
each year (first review [...***...]) to reflect any increase in the UK Consumer Price Index: All Items Index published by the Office for National Statistics (as published at www.ons.gov.uk, specific details are located at
http://www.ons.gov.uk/ons/rel/cpi/consumer-price-indices during the previous 12 months (based on the average of the monthly changes over the 12-month period). Patheon shall invoice Flexion monthly for any Additional Services performed by Patheon
during the preceding month in accordance with ARTICLE IV. 
 (h) If Flexion decides to have Patheon perform Manufacturing
Services for the Product for a Territory outside the [...***...], then Flexion will inform Patheon of the additional requirements for each new country and Patheon will prepare a quotation for consideration by Flexion of any additional costs
for the Product destined for each new country. The agreed additional requirements and change over fees will be set out in a written amendment to this Agreement. 

(i) Patheon-Supplied Materials. 

(i) Patheon will purchase all Patheon-Supplied Materials. Flexion understands and acknowledges that Patheon will rely on
Flexion’s Purchase Orders and Forecasts in ordering the Patheon-Supplied Materials required to meet the Purchase Orders. In addition, Flexion understands that to ensure an orderly 

  
  

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supply of Patheon-Supplied Materials, Patheon may want to purchase Patheon-Supplied Materials in sufficient volumes to meet the production requirements for Products during part or all of the
Forecast or to meet the production requirements of any longer period agreed to by Patheon and Flexion. Accordingly, Flexion authorizes Patheon to purchase Patheon-Supplied Materials to satisfy the Manufacturing Services requirements for Products for
the first [...***...] contemplated in the most recent Forecast. Patheon may make other purchases of Patheon-Supplied Materials to meet Manufacturing Services requirements for longer periods if agreed to in writing by the Parties. Flexion will
give Patheon written authorization to order Patheon Supplied Materials for any launch quantities of Product request by Flexion which will be considered a Purchase Order when accepted by Patheon. Flexion will reimburse Patheon for any destruction
costs, as mutually agreed to in good faith, of any Patheon-Supplied Material ordered by Patheon under Purchase Orders or under Section 2.2(i) that are not included in finished Products Manufactured for Flexion within [...***...]
after the forecasted month for which the purchases have been made (or for a longer period as the Parties may agree). If any non-expired Patheon-Supplied Materials are used in Products subsequently manufactured for Flexion, Flexion will receive
credit for any costs of those Patheon-Supplied Materials previously paid to Patheon by Flexion. 
 2.3 Forecasting, Order, and Delivery
of Products. 
 (a) No later than [...***...] prior to the anticipated FDA Approval Date and thereafter at least
[...***...] prior to the [...***...] of each [...***...] during the Term, Flexion shall deliver to Patheon a written good faith [...***...] month forecast, calculated by month, estimating the quantities of each presentation
of Product that Flexion expects to purchase from Patheon during such period (each, a “Forecast”). If Patheon is unable to accommodate any portion of the Forecast, it will notify Flexion and the Parties will agree on any revisions to
the Forecast. Flexion shall update the Forecast on or before the [...***...] of each [...***...] on a rolling forward basis. Flexion shall use commercially reasonable efforts to also update the Forecast prior to the next
[...***...] deadline if it determines that the volumes estimated in the most recent Forecast have changed by more than [...***...] percent [...***...]%). The most recent Forecast will prevail. Except as set forth in
Section 2.3(c) below, each Forecast shall be non-binding and shall be used by Patheon for planning purposes only. 

(b) Commencing on [...***...], Flexion will give Patheon a written non-binding [...***...]-year forecast for
strategic purposes, of the volume of Product Flexion then anticipates to purchase from Patheon for each year during such period (the “Long Term Forecast”). The Long Term Forecast will thereafter be updated every six months (as of
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Term. If Patheon is unable to accommodate any portion of the Long Term Forecast, it will notify Flexion and the Parties will agree on any revisions to the Long Term Forecast. 

(c) [...***...]. Flexion will issue Purchase Order(s) to purchase and, when accepted by Patheon, for Patheon to
Manufacture and deliver the forecasted quantity or a quantity greater than the forecasted quantity of the Product for each such [...***...] period, provided that the delivery lead time must be at least [...***...] days from the date of
Patheon’s acceptance of the Purchase Order pursuant to clause (d) below. The quantities of Products ordered in Purchase Orders will be firm and binding on Flexion and may not be reduced by Flexion. Unless otherwise stated herein, expedited
Purchase Orders will be subject to additional fees. 
 (d) Patheon shall accept all Purchase Orders for Product that are
issued consistent with the terms of this Agreement. Patheon shall accept in writing any Purchase Order by sending an acknowledgement to Flexion within [...***...] business days of its receipt of the Purchase Order. The acknowledgement will
include, subject to confirmation from Flexion, the delivery date for the Product ordered which shall be approximately [...***...] days from the date of Patheon’s acceptance of the Purchase Order (“Agreed Delivery Date”)
and the scheduled date of production for such Products (“Scheduled Production Date”) for the purposes of Section 2.2(c). The Agreed Delivery Date may be amended by agreement of the Parties or as set forth in
Section 2.2(c). If Patheon fails to acknowledge receipt of a Purchase Order within the [...***...] business day period, the Purchase Order will be deemed to have been accepted by Patheon. 

(e) Patheon shall deliver Product to Flexion [...***...] the Facility (as defined in Incoterms 2010) by the Agreed
Delivery Date. All Product shall be packed for shipping in accordance with the Specifications. Title and risk of loss to Product shall pass to Flexion (or a designated Flexion Affiliate) [...***...]. Each delivery of Product shall be
accompanied by a Certificate of Analysis and a Certificate of Compliance and such other documents as may be required pursuant to the Quality Agreement. The costs of all freight, insurance, handling fees, taxes, and other costs associated with the
shipment of Product, as well as export licenses, import license, and customs formalities for the import and export of goods will be borne by [...***...]. Patheon shall endeavour to make all deliveries of Product hereunder utilizing stock
rotation based on expiration dating, with Product expiring earliest delivered first, save that a failure to comply with this requirement shall not be grounds for Flexion to reject any Product. Flexion shall collect shipments reasonably promptly from
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delivery from Patheon. Storage of Product will be as described in Section 2.2(e). Patheon will, in accordance with Flexion’s instructions and as agent for Flexion, at Flexion’s
risk, arrange for shipping to be paid by Flexion. Flexion will arrange for insurance and will select the freight carrier used by Patheon to ship Products and may monitor Patheon’s shipping and freight practices as they pertain to this
Agreement.
 (f) If Flexion cancels any Purchase Order after receipt thereof by Patheon, Flexion will pay Patheon
[...***...]% of the Product Fee for the Purchase Order. 
 2.4 Product Fees. The purchase price for all Products
Manufactured hereunder (the “Product Fee”) shall be as set forth on Schedule 2.1(a). Patheon shall invoice Flexion for all quantities of Product Manufactured and ready for collection by Flexion not previously invoiced in
accordance with Purchase Orders. All Product Fees will be due and payable in accordance with the invoicing procedures set forth in ARTICLE IV. 

2.5 Base Fees. Patheon will invoice Flexion monthly in advance for the Base Fee and any Phase I Filling Space Fee set forth
Schedule 2.1(a). All Base Fees and Phase I Filling Space Fees will be due and payable in accordance with the invoicing procedures set forth in ARTICLE IV. 

2.6 Product Fee Adjustment. The Parties shall use commercially reasonable efforts to reduce, through operating efficiencies, the cost
of Manufacture of the Products during the Term and the benefits of such reduction in costs shall be shared equally by the Parties. The Product Fee stated herein is calculated as at the
1st January 2015. Starting on the [...***...], the Product Fee shall be adjusted annually to reflect any increase in the UK Consumer Price Index: All Items Index published by the Office
for National Statistics (as published at www.ons.gov.uk, specific details are located at http://www.ons.gov.uk/ons/rel/cpi/consumer-price-indices/) during the preceding twelve (12) months (based on the average of the monthly changes over the
12-month period). Schedule 2.1(a) shall be deemed amended pursuant to the terms hereof. The Product Fee is subject to adjustment if, after [...***...] from the FDA Approval Date, (i) Flexion does not submit Purchase Orders for
at least [...***...] vials of Product per calendar year, in which case the Product Fee may increase by an amount reasonably sufficient for Patheon to absorb its increased costs, and (ii) Flexion submits Purchase Orders for more than
[...***...] vials of Product per calendar year, in which case the Product Fee may decrease for the volumes of Product exceeding [...***...] vials per calendar year as reasonably agreed-on by the Parties in order to adjust for additional
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 2.7 Failure or Inability to Supply Product. 

(a) Patheon shall ensure that Product is Manufactured and delivered to Flexion on a timely basis consistent with the terms of
this Agreement (including the Forecast and Purchase Order procedures set forth in Section 2.3). In the event that Patheon, at any time during the Term, shall have reason to believe that it will be unable to supply Flexion with the full quantity
of Product forecasted to be ordered or actually ordered by Flexion in a timely manner and in conformity with the warranty set forth in Section 6.3 (whether by reason of force majeure or otherwise), Patheon shall notify Flexion thereof within
[...***...] business days. Promptly thereafter, the Parties shall meet to discuss how Flexion shall obtain such full quantity of conforming Product. Compliance by Patheon with this Section 2.7(a) shall not relieve Patheon of any other
obligation or liability under this Agreement, including any obligation or liability under clause (b) below. If Patheon’s inability is partial, Patheon shall fulfill Purchase Orders with such quantities of Product as are available. In the
event Patheon’s inability to meet Purchase Orders or forecasts is due to a shortage of production capacity in the Manufacturing Suite, Patheon shall in addition to the foregoing requirements, promptly notify Flexion of such shortage of
production capacity and the estimated date such shortage of production capacity is to end. 
 (b) If Patheon fails to
Manufacture the full quantity of Product specified in a Purchase Order by the Agreed Delivery Date and in conformity with the warranty set forth in Section 6.3 (and such failure is directly due to the acts or omissions of Patheon where such
acts or omission does not constitute a force majeure event pursuant to the terms of Section 10.2) (“Late Product”), and Patheon is unable to cure such failure within [...***...] days, in full and final settlement of such
failure, Flexion, at its option, may (i) cancel the unfulfilled portion of such Purchase Order, in which event Flexion shall have no liability with respect to the portion of such Purchase Order so cancelled, or (ii) accept late delivery of
all or any portion of the Product specified in such Purchase Order, in which event (A) Patheon shall pay all reasonable documented shipping costs for the expedited shipment of Product that are required in addition to the shipping costs for a
non-expedited shipment (which shall be the responsibility of Flexion), and (B) the Product Fee otherwise payable by Flexion with respect to all Product delivered late but accepted by Flexion under such Purchase Order shall be reduced by
[...***...]% per day for each day of delay after such Agreed Delivery Date, but not to exceed in aggregate an amount equal to [...***...]% of the Product Fees of the Product delivered late (i.e., [...***...] days) per Purchase
Order; provided that, sub-Section (ii) shall only apply after the Manufacture and delivery of the first [...***...] batches of commercial Product (including validation batches) pursuant to this Agreement, following which, if the Parties
agree that the Manufacturing process is sufficiently robust to allow the Product to be delivered in a timely manner, this sub-Section (ii) 

  
  

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shall be implemented. Any Product which is delivered to Flexion with less than [...***...] of expiry, assuming a product shelf life of [...***...], shall be considered Non-Conforming
Product subject the provisions of Section 2.8(c); provided that, if the Product shelf life is not [...***...] (as set forth in the FDA approved label for the Product), the Parties shall mutually agree in good faith on the reasonably
appropriate minimum amount of expiry a Product should have when delivered. 
 2.7 A. Batch Numbering and Expiration Dates: Each
batch of the Product manufactured by Patheon will bear a unique lot number using Patheon batch numbering system. This number will be printed on the aluminium cap of the vial and will appear on all documents relating to the particular batch of
Product and shall identify the date of manufacture for the batch of Product. Patheon will calculate the expiration date for the Product for each batch by adding the expiration period of the Product supplied by Flexion to the date of manufacture of
each batch. 
 2.8 Non-Conforming Product. 

(a) In the event Patheon discovers a potential Non-Conforming Product prior to delivery of such Product to Flexion, Patheon
shall provide written notice to Flexion as soon as practicable describing in detail the Non-Conforming Product and the potential cause of such Non-Conforming Product. Flexion (or its shipping carrier) will perform a customary inspection of the
Products Manufactured by Patheon on receipt. For the avoidance of doubt, such inspection will be limited to a visual inspection of the shipment-ready packaged Products (and associated shipping documentation) and Flexion will not be obliged to
perform any testing of the Product. Flexion shall within (i) [...***...] days after delivery thereof by Patheon or (ii) within [...***...] days after Flexion discovers or is informed of a discovery of nonconformity that could
not reasonably have been detected by the customary inspection on delivery (but not after the expiration date of the Product), give Patheon notice of any Non-Conforming Product (including a sample of such Non-Conforming Product, if applicable) (a
“Deficiency Notice”). Subject to Flexion’s rights under 3.10 and 3.12, should Flexion fail to give Patheon the Deficiency Notice within the applicable [...***...] day period, then the delivery will be deemed to have been
accepted by Flexion on the [...***...] day after delivery or discovery, as applicable. Patheon shall have no liability under this Section 2.8 for Nonconforming Product for which it has not received a Deficiency Notice within such
applicable [...***...] day period. 
 (b) Patheon shall conduct a root-cause analysis to verify whether a Product
constitutes a Non-Conforming Product and, if found, to determine the cause of such Non-Conforming Product (including by undertaking an appropriate evaluation of a Non-Conforming Product sample, as applicable). 

  
  

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 Flexion shall provide reasonable cooperation to Patheon in connection with any such root-cause
analysis. Patheon shall notify Flexion in writing of its determination regarding whether the Product constitutes a Non-Conforming Product within [...***...] days after either discovery of the Non-Conforming Product or receipt of such
Deficiency Notice from Flexion, as applicable. Such notification shall include Patheon’s good faith determination of the cause of the Non-Conforming Product. 

(c) “Patheon Nonconformance” shall mean (i) Patheon’s failure to perform [...***...] pursuant
to Section [...***...], and (ii) Patheon’s failure to provide the [...***...] in accordance with the [...***...]. In the event of a Non-Conforming Product caused by a Patheon Nonconformance, Patheon, at
Flexion’s option, promptly shall (x) supply Flexion with a conforming quantity of Product at Patheon’s expense (subject to Flexion supplying Patheon with Flexion-Supplied Materials and Patheon reimbursing Flexion for the actual costs
of [...***...]) and reimburse Flexion for any incurred shipment costs in the event that the Non-Conforming Product was shipped from the Facility at the time of the discovery of the Patheon Nonconformance (“Shipment Costs”));
or (y) reimburse Flexion for the applicable Product Fee (including the cost of any Patheon-Supplied Materials), the actual costs of the [...***...] and Shipment Costs with respect to such Non-Conforming Product (in each case, to
the extent already paid by Flexion). For each of (x) and (y) above, Patheon’s obligation to reimburse [...***...] shall be subject to the limitation of liability in Section 9.5(a) herein but Section 9.5(a)
(1) shall not apply in relation to the internal expenses incurred by Patheon to supply conforming Product to Flexion pursuant to (x), including the cost of any Patheon-Supplied Materials or any Shipment Costs, and (2) shall not apply to
the reimbursement of the Product Fee pursuant to (y). For the avoidance of doubt, Flexion will not be liable for Product Fees for Non-Conforming Product caused by a Patheon Nonconformance. 

(d) If the Non-Conforming Product was caused by any reason other than a Patheon Nonconformance or the cause of such
non-conformance is not due to Patheon Nonconformance (where applicable, as may be determined by an Expert in accordance with 2.8(e), Flexion shall be liable for all expected Product Fees for such Non-Conforming Product, to the extent not already
paid. 
 (e) If, following the root-cause analysis described in Section 2.8(b), Patheon notifies Flexion that it does
not believe the Product is a Non-Conforming Product, or if the Parties disagree as to the cause of a Non-Conforming Product, the Parties shall first submit such dispute to the Project Managers for prompt resolution. If the Project Managers cannot
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shall submit the dispute to an independent expert or (if mutually agreed to by the Parties) a testing lab, each as agreed by the Parties (a “Expert”) for evaluation,
provided that both Parties shall be entitled to observe and obtain copies of all results of such evaluation. The Expert shall determine (i) whether the Product is a Non-Conforming Product and (ii) the cause of the Non-Conforming Product;
provided that, if the cause of the Non-Conforming Product is undeterminable the Expert shall give an opinion as to the likely cause. Both Parties shall cooperate with the Expert’s reasonable requests for assistance in connection with its
evaluation hereunder. The findings of the Expert shall be binding on the Parties, absent fraud or manifest error. The expenses of the Expert shall be borne (x) by Patheon if the testing confirms the Non-Conforming Product and the cause or
likely cause is found to be a Patheon Nonconformance; (y) by Flexion if the testing confirms the Non-Conforming Product and the cause or likely cause is found not to be a Patheon Nonconformance or the cause or likely cause of such
non-conformance is not identifiable; and (z) by the Party stating the Product was Non-Conforming in the event the testing concludes that the Product meets the warranty set forth in Section 6.3. Costs of dealing with Product Complaints and
Inquiries will be dealt with in accordance with Section 3.10. Costs of recalls will be dealt with in accordance with Section 3.12. Patheon shall have no liability for any Non-conforming Product unless such Non-conforming Product is
identified as being due to a Patheon Nonconformance (where applicable, as may be determined by an Expert in accordance with 2.8(e). 

(f) During its performance of the Manufacturing Services, Patheon is expected to produce a certain percentage of saleable
batches of Product (the “Yield”). For the avoidance of doubt, Nonconforming Product arising from anything other than a Patheon Nonconformance is treated as good and saleable Product for the purposes of this Section 2.8(f). The
Parties shall calculate and mutually agree on the expected Yield after each anniversary of the initial batch of commercial Manufacture of Product and based on at least [...***...] batches of Product (the “Expected Yield
Rate”). In the event the actual Yield in any calendar year is more than [...***...]% lower than the then-current Expected Yield Rate for such calendar year, (i) Patheon and Flexion will engage in good faith discussions to agree
to a remediation plan describing the steps to be taken to achieve the then-current Expected Yield Rate and (ii) Patheon will reimburse Flexion for [...***...] used by Patheon as a result of Patheon’s failure to meet the Expected
Yield Rate in such batches (i.e., a pro-rated refund of [...***...] paid by Flexion and/or reimbursement to Flexion for the costs of any [...***...]) subject to the limitation of liability in Section 9.5(a) (the “Yield
Reimbursement Payment”). In the event the actual Yield in any calendar year is more than [...***...]% greater than the then-current Expected Yield Rate for such calendar year, Patheon shall be entitled to reduce any Yield
Reimbursement Payment to be made in the next calendar year by an amount equal to the excess Materials that would have been 

  
  

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used by Patheon if the Yield for such calendar year was equal to the then-current Expected Yield Rate in such batches. 

2.9 Equipment and Amendment of Product Specifications, Manufacturing Process, Equipment and Formulation. 

(a) Equipment. 

(i) “Flexion Manufacturing Equipment” shall mean process equipment necessary to Manufacture the bulk Product
and shall consist of equipment for the bulk Manufacturing, vial preparation, fill/finish, and in-process control testing of the Product and its intermediates as more fully set forth on Schedule 2.9 attached hereto which must comply with all
EU mandatory requirements including without limitation, Supply of Machinery (Safety) Regulations 2008 (UK Regulations, Secondary UK Legislation), Electrical equipment of machines (General requirements BS EN 60204-1:2006+A1:2009) (British Product
Standards), Machinery Directive 2006/42/EC (European Union Directive), Low Voltage Directive (LVD) 2006/95/EC (European Union Directive), and Electromagnetic Compatibility (EMC) Directive 2004/108/EC (European Union Directive). 

(ii) “Patheon Manufacturing Equipment” shall mean any equipment, other than the Flexion Manufacturing
Equipment, necessary to Manufacture the Product including as more fully set forth in Schedule 2.9 attached hereto, waste handling systems and all building infrastructure and any and all improvements or additions made thereto, as approved in
writing by Flexion.  
 (iii) Patheon, acting as Flexion’s agent, shall purchase the Flexion Manufacturing
Equipment on Flexion’s behalf and pursuant to Flexion’s written instruction. The inclusion of items of Flexion Manufacturing Equipment in Schedule 2.9, as may be amended by agreement from time to time, shall constitute written instruction
to purchase. Title to all Flexion Manufacturing Equipment will be held by Flexion unless otherwise set forth in Schedule 2.9. Title to all Patheon Manufacturing Equipment will be held by Patheon. 

(iv) Patheon is authorized to use the Flexion Manufacturing Equipment solely for the purposes of performing the Manufacturing
Services for Flexion. 
 (v) During the Term, Flexion shall be responsible for additions and replacement cost of any Flexion
Manufacturing Equipment and Patheon Manufacturing Equipment. 
 (vi) During the Term, Patheon shall, at its sole cost and
expense, subject to this subsection (vi), provide all Maintenance for the Equipment and Facilities. Notwithstanding the foregoing, with respect to the Flexion Manufacturing Equipment and Patheon Manufacturing Equipment, Maintenance does not include
(A) the cost of spare parts, (B) Equipment breakdowns caused by any reason outside of Patheon’s reasonable control (other than breakdowns caused 

  
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by Patheon’s negligence or failure to maintain the Equipment in accordance with the applicable Equipment Standard Operating Procedures of Patheon or the manufacturer’s terms of
operation and recommended procedures), or (C) specialized maintenance services not within Patheon’s technical expertise or that requires specialist equipment, in each case where Patheon is required to utilize a Third Party contractor.
Patheon’s costs associated with such spare parts and Third Party contractors will be reimbursed by Flexion as a Bill Back Item. Patheon shall not be liable for ordinary wear and tear of the Flexion Manufacturing Equipment or Patheon
Manufacturing Equipment; Patheon shall only be liable for the repair or replacement of any damage caused to such Equipment where such damage arises due to its negligence or willful misconduct or its failure to maintain Equipment pursuant the
applicable Equipment Standard Operating Procedures of Patheon or the manufacturer’s terms of operation and recommended procedures. Throughout the Term of this Agreement, Patheon shall maintain property insurance on Flexion Manufacturing
Equipment in the amount equal to the replacement value of such Equipment. 
 (b) For changes to the Specifications, Quality
Agreement, Flexion’s Manufacturing Process, the Equipment, the Services to be provided pursuant hereto or the formulation of the Product that are required by Applicable Law (collectively, “Required Manufacturing Changes”),
Patheon and Flexion shall cooperate to promptly make such changes within the required timeline. 
 (c) For changes to the
Specifications, Quality Agreement, Flexion’s Manufacturing Process, the Equipment, the Services to be provided hereto or the formulation of the Product that are not Required Manufacturing Changes (collectively, “Discretionary
Manufacturing Changes”), Patheon and Flexion must each agree to any Discretionary Manufacturing Changes and shall cooperate in making such changes, and each agrees that it shall not unreasonably withhold, condition or delay its consent to
such Discretionary Manufacturing Changes. 
 (d) Notwithstanding the foregoing, all internal and external costs, including,
without limitation, costs of obsolete Materials, work-in-process and Product (i) associated with Required Manufacturing Changes shall be borne by Flexion, and (ii) all such costs associated with Discretionary Manufacturing Changes shall be
agreed between the Parties; provided that, in each case, all such costs shall be commensurate with costs common in the industry for the types of changes being made. 

(e) In the event that Flexion changes the Specifications, Quality Agreement, Flexion’s Manufacturing Process, the
Equipment, the Services to be provided hereto or the formulation of the Product, or consents to any change by Patheon, Patheon shall provide to Flexion at Flexion’s cost as an Additional Service any such documentation or other information with
respect thereto as they relate to the Manufacturing Services as Flexion may reasonably request in order to obtain or maintain any Regulatory Approval or comply with GMP or other Applicable Law. 

  
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 2.10 Phase I Filling Space Option. 

(a) Prior to the Phase III Manufacturing Suite Clearance Date, Patheon shall provide the Manufacturing Services utilizing the
Phase I Filling Space and Phase II Manufacturing Space. During this period, the Phase I Filling Space Fee set forth in Schedule 2.1(a) shall be payable if a period of [...***...] has elapsed after the date on which Flexion submitted for
approval to the FDA or other applicable Regulatory Authority for the Manufacture of Product in the Phase III Manufacturing Suite for commercial sale in the Territory. The Phase I Filling Space Fee shall cease to be payable on the Phase III
Manufacturing Suite Clearance Date unless Flexion exercises the Phase I Option. 
 (b) After the Phase III Manufacturing
Suite Clearance Date, (1) Patheon will provide the Manufacturing Services set forth herein utilizing the Phase II Manufacturing Space and Phase III Manufacturing Suite and (2) Flexion shall have the option to elect to have Patheon continue
to provide the Manufacturing Services utilizing the Phase I Filling Space for all or any portion of the remaining Term (the “Phase I Option”), provided that, (i) Flexion pays the Phase I Filling Space Fee set forth in
Schedule 2.1(a) commencing after election of the Phase I Option, and (ii) the Phase I Option shall cease to be applicable if Flexion does not exercise the Phase I Option within [...***...] from Patheon’s notice to Flexion that
[...***...]. After the Phase III Manufacturing Suite Clearance Date, Patheon shall have no obligation to provide the Manufacturing Services utilizing the Phase I Filling Space unless Flexion has exercised the Phase I Option in accordance with
this Section 2.10(b). 
 (c) The extent of the use of the Phase I Filling Space for the Manufacturing Services shall be
at Flexion’s sole discretion both prior to and after the Phase III Manufacturing Suite Clearance Date except that the Parties acknowledge that the Phase I Filling Space will [...***...] after the Phase III Manufacturing Suite Clearance
Date. The Parties shall discuss and agree [...***...] in good faith but any associated costs or fees would be payable by [...***...]. 

(d) For purposes of this Section 2.10, the “Phase III Manufacturing Suite Clearance Date” shall mean the
date upon which, in Flexion’s sole discretion, the FDA or other applicable Regulatory Authority, has approved or will allow the Product to be Manufactured in the Phase III Manufacturing Suite for commercial sale in the applicable Territory.

  
  

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 ARTICLE III. REGULATORY, ACCESS, AND OTHER MATTERS 

3.1 Quality Agreement. Within [...***...] of the Effective Date, the Parties shall enter into a mutually agreed upon quality
agreement (“Quality Agreement”). If the is any inconsistency between this Agreement and the Quality Agreement, the terms of the Quality Agreement shall control solely with respect to quality issues, and this Agreement shall control
with respect to all other issues. 
 3.2 Release. All Product shall be released in accordance with the terms of the Quality
Agreement. 
 3.3 Maintenance of Facility. 

(a) Patheon shall Manufacture the Product [...***...] at the Facility, unless Flexion has granted prior written consent
to Manufacture the Product at any other facility, such consent to be granted by Flexion in its sole discretion. 
 (b)
Subject to Section 2.9(b)-(d), Patheon shall ensure that any and all necessary licenses, registrations, and Regulatory Authority approvals have been obtained in connection with the Facility and Equipment used in connection with the Manufacture
of the Product by Patheon. 
 (c) Subject to Section 2.9, Patheon shall maintain the Facility and Equipment in a state
of repair and operating efficiency consistent with the requirements of the Specifications, the Regulatory Approvals, Flexion’s Manufacturing Process, GMP, and all other Applicable Law. Prior to each use of Equipment in Manufacturing the
Product, Patheon shall ensure that such Equipment is cleaned and consistent with any procedures reasonably established by Flexion and notified to Patheon, the Specifications, the Regulatory Approvals, Flexion’s Manufacturing Process, GMP, and
all other Applicable Law. Without limitation of the foregoing, Patheon agrees to implement, in connection with the Manufacture of the Product, quality assurance and quality control procedures, including validation protocols and process change
procedures that are reasonably satisfactory to Flexion. 
 (d) Patheon shall maintain in the Facility an adequate GMP and
temperature controlled area for the Product, all intermediates thereof, and Materials used in Manufacturing the Product in accordance with the Specifications, the Regulatory Approvals, Flexion’s Manufacturing Process, any risk mitigation plan,
the Quality Agreement, GMP, and all Applicable Law. All Product, intermediates and Materials (as applicable) shall be held by Patheon in a GMP and temperature controlled area (on a separate pallet and SAP reference from other products) until
delivery to Flexion. 

  
  

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 (e) Patheon shall only use qualified disposal services or sites that have
appropriate environmental and operating permits and are in compliance with the Quality Agreement and Applicable Law. 
 3.4 Flexion On
Site Representatives; Project Managers. For so long as Patheon is obliged to Manufacture and supply the Products for Flexion, Flexion shall have the right at all times throughout the Term to have [...***...] representatives present (or
other number as reasonably requested by Flexion after discussion by the members of the Steering Committee) (each, a “Flexion On Site Representative”) in that portion of Patheon’s Manufacturing facilities that is being used to
Manufacture the Product or store Materials to observe the procedures and processes used to Manufacture the Product. Subject to the following sentence, such representatives shall have full access to the Manufacturing Suite and to all non-financial
records that relate to the Product, the Materials and Bill Back Items. Patheon shall provide reasonable (semi-permanent) on-site accommodations at the Facility for the Flexion On Site Representatives (e.g., office space). For the avoidance of
doubt, the term “non-financial records” as used in this Agreement does not include the Reports (defined in Section 3.11 below). Flexion On Site Representatives shall be appropriately trained by Flexion (e.g. GMP training) and shall
observe at all times Patheon’s policies and procedures (as amended from time-to-time) as they pertain to the Facility, including policies relating to health and safety and compliance with GMP, and comply with all reasonable directions of
Patheon in relation to the same; provided that Flexion is given notice of such policies and given a reasonable period of time to review and implement such policies. Patheon may refuse or limit in its sole discretion at any time admission to the
Facility by any Flexion On Site Representative who fails to observe such policies or comply with such reasonable directions. For the avoidance of doubt, Flexion On Site Representatives shall have (i) no management authority over any Patheon
employee and (ii) no authority to conclude contracts on behalf of Flexion. Patheon and Flexion will each appoint a project manager (each, a “Project Manager” and, together, the “Project Managers”), who will
meet as needed to resolve any issues or problems arising in the performance of this Agreement. Flexion’s Project Manager may be one of the Flexion On Site Representatives. 

3.5 Notification of Regulatory Inspections. Patheon shall notify Flexion by telephone within [...***...], and in writing within
[...***...], after learning of any proposed or unannounced visit or inspection of any part of the Facility by any Regulatory Authority, including the Occupational Safety and Health Administration or any equivalent governmental agencies of the
country of Manufacture, and shall permit Flexion or its agents to be present at the Facility to support Patheon during such visit or inspection if it, directly or indirectly relates to the Product or Manufacturing Suite or may reasonably be expected
to adversely affect the Product or the Manufacturing Suite. For the avoidance of doubt the responsibility for conducting the inspection rests with Patheon. Flexion personnel will be permitted to take part in the inspection where this participation
is directly requested either by the authorized agent of the Regulatory Authority or by Patheon. Patheon shall provide to Flexion in so far as it, directly or indirectly, affects the Product or the Manufacturing Suite or may reasonably be expected to
adversely affect the Product or the 

  
  

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Manufacturing Suite, either a copy of any report and other written communications received from such Regulatory Authority in connection with any visit or inspection, including the Form 483
observations and responses or any equivalent form under Applicable Law. Such copy or summary shall be provided to Flexion within [...***...] business days of Patheon’s receipt thereof (and may be redacted as Patheon acting reasonably
deems necessary to protect the confidentiality of matters not affecting, or not reasonably likely to affect, the Product or the Manufacturing Suite which are confidential to Patheon or to other clients of Patheon). Flexion shall have the right to
review and comment on any communications with such Regulatory Authority pertaining to such inspection as set forth in Section 3.15. 

3.6 Manufacturing Records. Patheon shall maintain, or cause to be maintained, (a) all records necessary to comply with GMP and
all other Applicable Law relating to the Manufacture of Product, (b) all Manufacturing records, standard operating procedures, equipment log books, batch records, laboratory notebooks, and all raw data relating to the Manufacturing of the
Product, and (c) such other records as Flexion may reasonably require in order to ensure compliance by Patheon with the terms of this Agreement. The template, form and style of all records referred to herein are the exclusive property of
Patheon; Flexion Proprietary Information and all Product-specific related information contained in these records shall be deemed Proprietary Information of Flexion and be retained for such period as may be required by GMP and all other Applicable
Law or for such longer period as Flexion may reasonably require. 
 3.7 Compliance with Applicable Laws. Patheon shall comply and
shall cause each of subcontractors and its Materials and Bill Back Items suppliers to comply with the Quality Agreement, GMP and Applicable Law in carrying out the Manufacturing of the Product and its other duties and obligations under this
Agreement. Should during the Term of this Agreement a change or changes in Applicable Law lead to Patheon (a) providing services not originally contemplated by Patheon, or (b) incurring increased costs in order to comply with said change
or changes, any such services or costs (to the extent pertaining to the Product or related to Flexion’s Manufacturing Process or Flexion Manufacturing Equipment) shall constitute an Additional Service subject to mutual written agreement of the
Parties. 
 3.8 Compliance Audits. Flexion and its designated representatives shall have the right to audit all applicable
non-financial records of Patheon for the purpose of determining Patheon’s compliance with the obligations set forth in this Agreement and the Technical Transfer Agreement, including Sections 2.2(a) and 6.2 of this Agreement, and the terms of
any Purchase Order. Such audit right shall include the right to inspect: (a) the Materials used in the Manufacture of the Product, (b) the holding facilities for such Materials and Product, (c) the Equipment used in the Manufacture of
the Product, (d) all non-financial records relating to the Manufacturing Suite and the Manufacturing of the Product (subject to any other restrictions set forth in this Agreement) and (e) all other documentation set forth in the Quality
Agreement. Flexion shall provide Patheon with reasonable prior advance notice of its intention to conduct such audit and the Parties will determine a mutually agreeable date for such audit. 

  
  

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Flexion shall include no more than [...***...] of Flexion’s representatives in each such audit, with each such audit lasting no more than [...***...] days without Patheon’s
prior written consent. Flexion may exercise its audit rights under this Section 3.8 no more than [...***...] per calendar year; provided that, in the event any of the following circumstances arise, Flexion may elect and Patheon shall
permit Flexion to conduct additional audits in a timely manner: (i) where there is the occurrence of a condition or event relating to the Materials or any Product which constitutes a serious health risk; (ii) where either Party has
received correspondence or a report from a Regulatory Authority pointing out a deficiency in the Product by or on behalf of Patheon; (iii) where the Specifications have not been complied with or there is otherwise evidence that compliance with
the Specifications is at risk; or (iv) in the event of a recall related to the Product. The Steering Committee will discuss the findings of any audit conducted by Flexion under this Section 3.8 and shall mutually agree upon a plan to
remedy any issues identified by Flexion in such audit and Patheon shall use commercially reasonable efforts to implement such plan in a timely manner. Patheon will support the first Product approval, including its inspection if required, of the FDA
or equivalent regulatory launch for other jurisdictions (where applicable) (a “PAI”) (including one mock-readiness review and efforts conducted with Flexion representatives in advance of such inspection). Patheon will be prepared
for the successful completion of the PAI with respect to the Manufacturing of the Product at the Facility a minimum of [...***...] in advance of the anticipated date of the PAI and Patheon will cooperate with Flexion to prepare for and to
complete the PAI in accordance with guidelines and requirements set forth by the applicable Regulatory Authority. Additional support (including, without limitation, subsequent regulatory launches or Product approval inspections/resulting reports for
other jurisdictions) will be subject to additional fees. 
 3.9 Inventory Reviews. Without limiting the foregoing, Flexion shall
have the right, with Patheon’s assistance, to conduct an annual inventory count of the Materials and of the Products. Following an audit or inventory, Flexion may discuss its observations and conclusions with Patheon, and Patheon shall promptly
implement such corrective actions after notification thereof by Flexion. In the event the Parties are unable to agree upon whether or not corrective actions are necessary, such dispute shall be resolved pursuant to the terms of Section 10.9.

 3.10 Product Inquiries and Complaints. 

(a) With respect to Products Manufactured by Patheon, each Party will promptly (as may be further defined in the Quality
Agreement) submit to the other Party any Product safety and efficacy inquiries, Product quality complaints, and adverse drug event reports received by such Party, together with all available evidence and other information relating thereto, in
accordance with procedures to be agreed upon by the Parties. Except as otherwise required by, or to comply with, Applicable Law or the terms of this Agreement, Flexion, as the Party holding the applicable Regulatory Approval, will be responsible for
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and responding to all such inquiries, complaints, and adverse events regarding the Product, and reporting to the FDA or any other Regulatory Authority. 

(b) Pursuant to a reported complaint or adverse drug event pertaining to the Products Manufactured by Patheon, if the nature
of the reported complaint or adverse drug event requires testing, Patheon will, upon Flexion’s request and approval, perform analytical testing of corresponding Product complaint or retention samples and provide the results thereto to Flexion
as soon as reasonably practicable, but no later than [...***...] days after Flexion’s request. Such testing shall be performed using approved testing procedures as set forth in the applicable Regulatory Approval or the Quality Agreement.
If such analytical testing concludes that the reported complaint or adverse drug event was the result of a Patheon Nonconformance, Patheon shall reimburse Flexion for [...***...] associated with such complaint or adverse drug event and
incurred by Flexion with respect to such nonconforming Product, including [...***...]. Costs of recalls will be dealt with in accordance with Section 3.12. If such analytical testing concludes that the reported complaint or adverse drug
event was not the result of a Patheon Nonconformance, Flexion shall compensate Patheon for all costs associated with such complaint or adverse drug event and incurred by Patheon with respect to such nonconforming Product, including costs of recalls,
market withdrawals, returns, and destruction. 
 (c) If the Parties disagree as to which Party is responsible, Patheon and
Flexion representatives shall attempt to resolve such dispute. If the representatives cannot resolve such dispute within [...***...] days, the retention samples shall be submitted by Patheon and Flexion to an Expert and Section 2.8 shall
apply. 
 3.11 Reports. Prior to the start of Patheon’s commercial Manufacture of the Product (or as reasonably requested by
Flexion prior to such date), Patheon and Flexion will work together in good faith to develop and agree upon Patheon’s ordinary course reporting obligations. Such reports (“Reports”) will include those reports as necessary for
Flexion to (a) manage Product inventory; (b) manage its financial close and reporting; (c) monitor on-going Product and process performance for its internal analysis and reporting; and (d) comply with Applicable Law. Patheon will
deliver such reports via electronic delivery methods, including by utilizing Patheon’s existing IT systems as practicable. 

3.12 Product Recalls. 

(a) In the event (i) any Regulatory Authority issues a request, directive, or order that Product be recalled, (ii) a
court of competent jurisdiction orders such a recall, or (iii) Flexion as holder of the applicable Regulatory Approval shall reasonably determine that Product should be recalled, withdrawn, or a field

  
  

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correction issued, the Parties shall take all appropriate corrective actions, and shall cooperate in the investigations surrounding the recall. In the event that Flexion determines that Product
should be recalled, to the extent reasonably possible, Flexion shall consult with Patheon prior to taking any corrective actions. In the event of any Product recall, withdrawal, or field correction resulting from a Patheon Nonconformance, Patheon
shall bear [...***...] associated with such recall, withdrawal, or field correction, which shall include [...***...] of the recalled Product and all other [...***...] incurred in connection with such recall, plus [...***...]
incurred by Flexion with respect to such Product. In all other circumstances, all costs associated with any Product recall, withdrawal, or field correction shall be borne by Flexion. 

(b) If there is any dispute concerning which Party’s acts or omissions gave rise to such recall of Product, Patheon and
Flexion representatives shall attempt to resolve such dispute. If the representatives cannot resolve such dispute within [...***...] days, the matter shall be submitted by Patheon and Flexion to an Expert and Section 2.8 shall apply. 

3.13 Payment Audits. 

(a) Upon [...***...] days’ prior written notice, Flexion may audit any Third Party invoices subsequently invoiced
to Flexion pertaining to Patheon’s provision of Equipment, Materials, Bill Back Items and Additional Services hereunder; provided, however, that Flexion will not be entitled to more than one audit during any [...***...] period. Such
audits will be conducted during normal business hours, without undue disruption to Patheon’s business, and may be conducted by Flexion, or by an independent public accounting firm designated by Flexion who is bound by confidentiality
obligations at least as stringent as those set forth in the Confidentiality Agreement. Except as hereinafter set forth, Flexion will bear the full cost of the performance of any such audit. 

(b) If, as a result of any audit described in Section 3.13(a), it is shown that the payments or credits from one Party to
the other under this Agreement with respect to the period of time audited were less than or more than the amount that should have been paid or credited, then the Parties will reconcile the amounts owed by each Party to the other. In addition, if
such audit demonstrates that Patheon has overcharged Flexion hereunder by more than [...***...]% for the period audited, then Patheon will also reimburse Flexion for its documented reasonable out-of-pocket costs and expenses incurred in
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 3.14 Subcontractors. Prior to subcontracting any of Patheon’s obligations hereunder,
Patheon will notify Flexion (1) in advance of engaging a proposed subcontractor that directly relates to the Manufacture of the Product and will obtain Flexion’s prior written approval of each such subcontractor, and (2) within six
(6) months, of all other subcontractors so engaged. The terms of any subcontract directly relating to the Manufacture of the Product will be in writing and will be consistent with this Agreement, including (i) the confidentiality
obligations set forth in Article VII, (ii) the representations and warranties of Patheon in Section 6.3, and (iii) compliance with Applicable Law as required hereunder. No subcontracting will release Patheon from its responsibility
for its obligations under this Agreement and Patheon will be responsible for the work and activities of each such subcontractor as they relate to performance of Patheon’s obligations under this Agreement, including compliance with the terms of
this Agreement. 
 3.15 Regulatory Filing Obligations. Except as otherwise set forth in this Agreement or the Technical Transfer
Agreement, each Party will be responsible for all routine filings and communications with Regulatory Authorities (“Regulatory Filings”) required with respect to such Party’s Regulatory Obligations hereunder. “Regulatory
Obligations” shall mean: (i) with respect to Flexion, any Regulatory Filings pertaining to the Product, Flexion’s Manufacturing Process, and filling and packaging processes and procedures; and (ii) with respect to Patheon,
any Regulatory Filings pertaining to the Facility, including in connection with a Facility inspection by a Regulatory Authority (e.g., those described in Section 3.5). For the avoidance of doubt, Flexion shall have the sole
responsibility and Regulatory Obligation for the filing of all documents with all applicable Regulatory Authorities, and to take any other actions that may be required, for the receipt of Regulatory Approval for the development or commercial
manufacture of the Product. Flexion shall provide Patheon with a copy of any Regulatory Approval directly relevant to this Agreement on request including any Regulatory Approval required for the storage, receipt or distribution of the Product by
Flexion or its designee. 
 (a) Cooperation. Each Party (“Non-Filing Party”) will provide reasonable
assistance and cooperation to the other Party (“Filing Party”) in the connection with the Filing Party’s Regulatory Obligations consistent with the terms of this Section 3.15 and the Non-Filing Party’s obligations
under this Agreement. The Filing Party shall notify the Non-Filing Party in writing of any written communications received by the Filing Party from a Regulatory Authority related to the other Party’s Regulatory Obligations within
[...***...] business days after receipt thereof. The Filing Party shall consult with the Non-Filing Party concerning the response of the Filing Party to each such communication, unless such filing is not relevant to the Non-Filing Party’s
Regulatory Obligations. 
 (b) Verification of Data. Prior to filing any documents or communications with a
Regulatory Authority that incorporate or uses data generated by the Non-Filing Party or otherwise relate to the Non-Filing Party’s Regulatory Obligations, the Filing Party will give the Non-Filing Party a draft of

  
  

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such document or communication (“Initial Draft”) to give the Non-Filing Party the opportunity to verify the accuracy and regulatory validity of such Initial Draft. The Non-Filing
Party shall be given a minimum of [...***...] calendar days to review the Initial Draft, but the Parties may mutually agree to a different time for the review as needed under the circumstances. The Initial Draft may be redacted by the Filing
Party as reasonably deems necessary to protect the confidentiality of matters not affecting the Non-Filing Party or which are confidential to the Filing Party or to other clients or customers of the Non-Filing Party. The Parties agree that in
reviewing the Initial Draft, the Non-Filing Party’s role will be limited to verifying the accuracy of the description of its Regulatory Filing Obligations or accuracy of its data or information in the Initial Draft. Notwithstanding the
forgoing, nothing in this Section 3.15(b) shall be deemed to limit a Party’s ability to make any filing with, or otherwise communicate with, any Regulatory Authority if such Party reasonably determines that such filing or communication is
legally required and must be made in an expedited manner and consultation with the other Party as provided herein is not reasonably possible. 

(c) Inaccuracies. If the Non-Filing Party determines that any of its data or information in the Initial Draft is
inaccurate or any other errors relating to the Non-Filing Party’s Regulatory Obligations, the Non-Filing Party will notify Filing Party in writing of such inaccuracy and provide a recommendation to remediate the Initial Draft. Such notice shall
also include documentation and data sufficient to substantiate the Non-Filing Party’s claim that the Initial Draft is inaccurate to the Filing Party’s reasonable satisfaction. The Non-Filing Party shall provide comments to the Initial
Draft no later than [...***...] days prior to the required filing date with the applicable Regulatory Authority. If the Non-Filing Party does not provide comments or notify the Filing Party of inaccuracies within such [...***...] day
period, the Non-Filing Party will be deemed to have approved any data or language related to its Regulatory Obligations in the Initial Draft. The Filing Party shall be required to incorporate the Non-Filing Party’s recommendations to the extent
they directly relate to an error in the Non-Filing Party’s data or information or the Non-Filing Party’s Regulatory Filing Obligations. The Parties will work together in good faith to resolve any inaccuracies contained in the Initial Draft
as soon as practicable under the circumstances to prevent a delay or postponement of such filing (or any related inspections by such Regulatory Authority to which the filing relates). Any on-going disagreement regarding the Deficiencies shall be
escalated to the Steering Committee for resolution on an expedited basis. 
 (d) Responsibilities. Patheon shall
deliver a copy of the final version of the filing to Flexion at least [...***...] days prior to the required filing date. Flexion shall deliver a copy of the final version of the filing to Patheon promptly after the required filing date.
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Party will not assume any responsibility for the accuracy of any other materials submitted by the Filing Party to a Regulatory Authority in connection with this Agreement. Except as otherwise set
forth in this Agreement or the Technical Transfer Agreement, the Filing Party is solely responsible for the preparation and filing of any materials required by a Regulatory Authority with respect to such Party’s Regulatory Filing Obligations
hereunder and any relevant costs will be borne by the Filing Party. 
 ARTICLE IV. FEES AND INVOICING 

4.1 General. (a) Patheon shall invoice Flexion for all applicable fees and charges incurred by Patheon as set out in this
Agreement or the Technical Transfer Agreement. (b) All invoices shall be sent electronically to [...***...]. Payment shall be due thirty (30) days after receipt by Flexion of an undisputed invoice. All payments from Flexion to
Patheon hereunder shall be in British Pounds (GBP). 
 4.2 Late Fees. In relation to all invoices issued by Patheon pursuant to this
Agreement, if Flexion fails to make any payment due to Patheon by the due date for payment, then, without limiting Patheon’s remedies under ARTICLE VIII or at law, Patheon may charge interest on past due accounts at [...***...]% per month
which is equal to an annual rate of [...***...]%. 
 4.3 Disputed Invoices. If Flexion disputes any portion of an invoice,
(a) Flexion shall provide Patheon with written notice of the disputed portion within [...***...] business days of receipt by Flexion of Patheon’s invoice and its reasons therefor and shall not be obliged to pay such disputed portion
unless and until such disputed portion is determined to be due and owing, and (b) Patheon shall cancel such invoice and issue a new invoice reflecting the undisputed invoiced amount, which shall be paid by Flexion within [...***...] days.
The Parties shall use good faith efforts to resolve the dispute regarding the disputed amount promptly, and if the Parties agree that a balance is due, Patheon shall issue an invoice for such balance, and payment shall be due [...***...] days
after receipt of such invoice. In the event of any inconsistency between an invoice and this Agreement, the terms of this Agreement shall control. 

4.4 Taxes. 
 (a) Subject
to (b) and (c) below, Patheon will bear all Taxes however designated as a result of the provision of the Services under this Agreement. 

(b) Flexion acknowledges that it will be responsible for all Taxes that arise in respect of the following: 

(i) The acquisition of the Flexion-Supplied Materials. 

  
  

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 (ii) The acquisition of the Flexion Manufacturing Equipment. 

(c) Any payment due under this Agreement for the provision of Services to Flexion by Patheon is exclusive of value added or equivalent tax in
any other jurisdiction, including any related interest and penalties (hereinafter all referred to as “VAT”). If any VAT is payable on a Service supplied by Patheon to Flexion under this Agreement, this VAT will be added to the
invoice amount and will be for the account of (and reimbursable to Patheon by) Flexion. Where applicable, Patheon will use its reasonable commercial efforts to ensure that its invoices to Flexion are issued in such a way that these invoices meet the
requirements for deduction of input VAT by Flexion, to the extent permitted by law to do so. 
 (d) Flexion acknowledges that all amounts
due in respect of any fees payable by Flexion under this Agreement shall be paid in full without any set-off, counterclaim, deduction or withholding in respect of any Tax liabilities. 

ARTICLE V. INTELLECTUAL PROPERTY 

5.1 Ownership. 

(a) Flexion shall maintain ownership and Control of all of its technology and intellectual property rights existing prior to
the Effective Date (“Existing Flexion Intellectual Property”). 
 (b) Patheon shall maintain ownership and
Control of all of its technology and intellectual property rights existing prior to the Effective Date (“Existing Patheon Intellectual Property”). 

(c) Existing Flexion Intellectual Property shall include and Flexion shall own all right, title, and interest in and to
(i) the Product, (ii) the Specifications, and (iii) Flexion’s Manufacturing Process. 
 (d) Existing
Patheon Intellectual Property shall include and Patheon shall own all right, title, and interest in and to the Patheon Manufacturing Equipment as of the Effective Date. 

(e) Flexion shall own all right, title, and interest in and to, all intellectual property (specifically including inventions
and patents and patent applications therefor) with respect to, and any data with respect to: 
 (i) (A) any improvement of,
modification of, change of, enhancement of, new indication for, new formula for, new formulation for, new ingredients for, new dosage for, new dosage strength for, new means of delivery for, or new labelling or packaging for, the Product
(“Flexion Product Improvements”); (B) any improvement of, modification of, change of, or enhancement of the Specifications (“Flexion Specification Improvements”); (C) any improvement of, modification of,
change of, enhancement of, new process for, new procedure for, or new step related to Flexion’s Manufacturing Process (“Flexion Manufacturing Process Improvements”); and (D) any improvements of, modification of, change

  
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of or enhancement of Flexion Manufacturing Equipment (the “Flexion Manufacturing Equipment Improvements”) in each of case (A), (B), (C) and (D) , (1) that is
developed, conceived, or created after the Effective Date specifically as a result of or in connection with this Agreement, including Patheon’s Manufacturing of the Product hereunder, (2) whether or not patentable, (3) whether
developed, conceived, or created by employees of, or consultants to, Flexion or Patheon, alone or jointly with each other or with permitted Third Parties (including permitted sublicensees and subcontractors), and (4) that has specific
applicability, meaning it does not have applicability to products other than the Product, to the Product, Specifications, Flexion’s Manufacturing Process or the Flexion Manufacturing Equipment as applicable (together the Flexion Specification
Improvements, Flexion Product Improvements, Flexion’s Manufacturing Process Improvements and the Flexion Manufacturing Equipment Improvements shall be referred to as the “Flexion Specific Improvements”);  

(ii) any improvement of, modification of, change of, enhancement of manufacturing, processing, formulating, filling, labelling
or packaging technology or equipment which is (x) developed, conceived, created, generated or derived after the Effective Date by Patheon, alone or jointly with Flexion or other permitted Third Parties (including permitted sublicensees)
specifically as a result of or in connection with this Agreement, and (y) of generic application to the Product, meaning it has application to or utility in relation to a range of products which includes the Product (“Non-Specific
Improvement”)(the Flexion Specific Improvements and the Non-Specific Improvements are together “Flexion Improvements”); and 

(iii) any inventions, know how or other intellectual property developed, conceived, or created by Flexion, alone or jointly
with Third Parties (other than Patheon or its Affiliates, or their respective employees and consultants), in the course of conducting activities outside the scope of this Agreement and without any use of any Existing Patheon Intellectual Property,
Patheon Independent Manufacturing Equipment Improvements and/or Patheon Non-Applicable Inventions (as defined hereunder). 

(f) Patheon shall own all right, title, and interest in and to, all intellectual property (specifically including inventions
and patents and patent applications therefor) with respect to, and any data with respect to: 
 (i) any improvement of,
modification of, change of, enhancement of Patheon’s Manufacturing Equipment, (1) that is developed, conceived, or created as a result of or in connection with this Agreement, including Patheon’s Manufacturing of the Product
hereunder, (2) whether or not patentable, (3) whether developed, conceived, or created by employees of, or consultants to, Flexion or Patheon, alone or jointly with each other or with permitted Third Parties (including permitted
sublicensees), and (4) that is of generic application rather than a specific solution that only has applicability to the Product, (“Patheon Independent Manufacturing Equipment Improvements”); 

  
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 (ii) any inventions, know how or other intellectual property developed,
conceived, or created by Patheon, alone or jointly with Flexion or other permitted Third Parties (including permitted sub-licensees), in the course of conducting activities under the scope of this Agreement where such inventions know how or other
intellectual property have no applicability to the Product, the Specifications, Flexion’s Manufacturing Process or the Flexion Manufacturing Equipment (“Patheon Non-Applicable Inventions”) (together the Patheon Independent
Manufacturing Equipment Improvements and the Patheon Non-Applicable Inventions are together “Patheon Improvements”); and 

(iii) any inventions, know how or other intellectual property developed, conceived, or created by Patheon, alone or jointly
with Third Parties, in the course of conducting activities outside the scope of this Agreement and without any use of any Existing Flexion Intellectual Property or Flexion Specific Improvements. 

(g) Patheon shall, and shall cause its Affiliates to, promptly disclose in writing and in reasonable detail to Flexion any
Flexion Improvements developed, conceived, or created by employees, consultants, or subcontractors of Patheon or its Affiliates, alone or jointly with employees, consultants or subcontractors of Flexion or its Affiliates. Such written notice will be
treated as the Proprietary Information of Flexion hereunder. 
 (h) Flexion shall, and shall cause its Affiliates to
promptly disclose in writing and in reasonable detail to Patheon any potential Patheon Improvement and any Flexion Non-Specific Improvements developed, conceived, or created by employees, consultants, or subcontractors of Flexion or its Affiliates,
alone or jointly with employees, consultants, or subcontractors of Patheon or its Affiliates. Such written notice in relation to Patheon Improvements will be treated as the Proprietary Information of Patheon hereunder. 

(i) The Specifications, Flexion’s Manufacturing Process, and any and all information or material related to the Existing
Flexion Intellectual Property, and Flexion Improvements shall constitute Proprietary Information of Flexion, which shall be deemed the disclosing Party with respect to such Proprietary Information and shall be subject to the provisions of Article
VII of this Agreement. 
 (j) Patheon’s Manufacturing Equipment and any and all information or material related to the
Existing Patheon Intellectual Property and Patheon Improvements shall constitute Proprietary Information of Patheon, which shall be deemed the disclosing Party with respect to such Proprietary Information. 

(k) Patheon shall, and shall cause its Affiliates, to disclose in writing and in reasonable detail to Flexion prior to the
implementation of any such Patheon Improvement or Non-Specific Improvement into the Manufacturing Services or any potential Patheon Improvements or Non-Specific Improvements and Flexion shall, in its sole discretion, decide whether such improvement
shall be 

  
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used in the Manufacture of the Product. Such written notice will be treated as the Proprietary Information of Patheon hereunder. 

(l) Patheon agrees to, and hereby does, and shall cause each of its employees, consultants, and Affiliates (collectively with
Patheon, the “Patheon Assignors”) to assign to Flexion all right, title and interest in and to the Flexion Improvements developed, conceived or created by such Patheon Assignors, alone or jointly with others including all
intellectual property rights associated therewith. Upon Flexion’s request and at Flexion’s sole expense, Patheon shall, and shall use commercially reasonable efforts to cause each Patheon Assignor to, assist Flexion or anyone Flexion
reasonably designates in preparing, filing, prosecuting, obtaining, enforcing or defending patent, copyright or other intellectual property application or grant of right issuing therefrom in any and all countries in the world. 

(m) Flexion agrees to, and hereby does, and shall cause each of its employees, consultants, and Affiliates (collectively with
Flexion, the “Flexion Assignors”) to assign to Patheon all right, title and interest in and to the Patheon Improvements developed, conceived or created by such Flexion Assignors, alone or jointly with others including all
intellectual property rights associated therewith. Upon Patheon’s request and at Patheon’s sole expense, Flexion shall, and shall use commercially reasonable efforts to cause each Flexion Assignor to, assist Patheon or anyone Patheon
reason ably designates in preparing, filing, prosecuting, obtaining, enforcing or defending patent, copyright or other intellectual property application or grant of right issuing therefrom in any and all countries in the world. 

5.2 Licenses. 

(a) Flexion hereby grants to Patheon a fully paid-up worldwide, non-exclusive license, under Flexion’s entire right,
title, and interest in and to the Existing Flexion Intellectual Property for Patheon to Manufacture the Products solely pursuant to the terms of this Agreement. 

(b) Flexion hereby grants to Patheon a fully paid-up worldwide, non-exclusive license, under Flexion’s entire right,
title, and interest in and to the Flexion Improvements, in each case to make Products solely pursuant to the terms of this Agreement. 

(c) Flexion hereby grants to Patheon a perpetual, irrevocable, fully paid-up worldwide, exclusive license, with the right to
grant sub-licences, under Flexion’s entire right, title, and interest in and to the Non-Specific Improvements for the manufacture, use, sale or supply of any and all products, except Excluded Products or any and all products which, at any time,
are owned by or exclusively licensed to Flexion. 
 In addition, Flexion grants to Patheon a perpetual, irrevocable, fully
paid-up worldwide, co-exclusive license, with the right to grant sub-licences, under Flexion’s entire right, title, and interest in and to the Non-Specific Improvements 

  
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for the manufacture, use, sale or supply of any and all products which, at any time, are owned by or exclusively licensed (in terms of the right of Flexion to sell such products) to Flexion
except Excluded Products. 
 Accordingly, notwithstanding anything to the contrary herein, Flexion retains: 

(i) co-exclusively with Patheon, rights to the Non-Specific Improvements for the manufacture, use, sale or supply of any and
all products which, at any time, are owned by or exclusively licensed (in terms of the right of Flexion to sell such products) to Flexion, and 

(ii) exclusively, any and all rights to the Non-Specific Improvements for the manufacture, use, sale or supply of Excluded
Products; 
 provided that, in either case (i) or (ii), 
  

	 	(1)	Flexion may only sublicense its rights to Non-Specific Improvements to a Third Party in conjunction with the license or assignment by Flexion of rights to manufacture, use, sell or supply a therapeutic product that is,
or were prior to the assignment, owned by or exclusively license (in terms of the right of Flexion to sell such products) to Flexion; and 

  

	 	(2)	other than with respect to permitted assignments of this Agreement under Section 10.5A herein Flexion shall not assign or otherwise transfer its right to Non-Specific Improvements without the prior written consent
of Patheon. In the event that Flexion wishes to assign any Non-Specific Improvement(s) to an Affiliate, Patheon and Flexion shall enter into a novation agreement with that Flexion Affiliate, to novate the rights and obligations hereunder in
respect of such Non-Specific Improvement(s) only. 

 For the purposes of this Section 5.2(c), “Excluded
Products” means any product which comprises as its active agent [...***...]. For the avoidance of doubt, co-exclusive means that only Patheon (and its authorised sub-licensees) and Flexion (and its authorised sub-licensees) has
rights in relation to the Non-Specific Improvements, such rights and the scope and nature of authorised sub-licensees being as expressly set out in this clause 5.2(c) and no wider. 

  
  

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 5.3 Technology Transfer. Upon the request of Flexion at any time during the
[...***...] period prior to expiry of this Agreement, Patheon shall, at Flexion’s cost (i) promptly disclose to Flexion or its designee any Patheon Improvement, (ii) have its representatives meet with representatives of Flexion
or its designee to enable Flexion or such designee to Manufacture the Product, and (iii) provide such other assistance as Flexion may reasonably request to enable Flexion or such designee to Manufacture the Product. Flexion shall reimburse
Patheon for its fees and all documented out-of-pocket expenses reasonably incurred by Patheon in connection with such technology transfer. Patheon will provide a quotation for the services which Flexion requires pursuant to this Section 5.3 as
Additional Services and on acceptance by Flexion of the same, Patheon will provide the services stated therein. 
 5.4 Third Party
Litigation. In the event that, during the Term, any Third Party institutes against Patheon any action that alleges that the Manufacture of the Product hereunder in accordance with the terms hereof infringes the intellectual property rights held
by such Third Party, then, as between Patheon and Flexion, and subject to Flexion indemnifying and defending and holding harmless Patheon in relation to such action pursuant Section 9.1(a)(iv) herein, Flexion, at its sole expense, shall have
the sole obligation to contest and assume discretion and control of the defense of such action, including the right to settle such action on terms determined by Flexion; provided, however, that in no event may Flexion agree to the entry of any
equitable or injunctive relief that is binding on Patheon and its Affiliates without Patheon’s prior written consent, not to be unreasonably withheld or delayed. Patheon, at Flexion’s expense, shall use all commercially reasonable efforts
to assist and cooperate with Flexion as reasonably request by Flexion in such action. 
 5.5 Licenses of Rights to Intellectual
Property. The licenses granted by the Parties hereunder shall be deemed to be licenses of rights to “intellectual property” as defined Section 101 of the United States Bankruptcy Code and, in connection therewith, each Party shall
have the rights set forth in Section 365(n) of the United States Bankruptcy Code in the event of any rejection or proposed rejection of this Agreement in any bankruptcy proceeding. 

ARTICLE VI. REPRESENTATIONS AND WARRANTIES 

6.1 Representations and Warranties of Each Party. Each Party hereby represents and warrants to the other Party as follows: 

(a) Such Party (i) is duly formed and in good standing under the laws of the jurisdiction of its formation, (ii) has
the power and authority and the legal right to enter into this Agreement and perform its obligations hereunder, and (iii) has taken all necessary action on its part required to authorize the execution and delivery of this Agreement and the
performance of its obligations hereunder. This Agreement has been duly executed and delivered on behalf of such Party and constitutes a legal, valid, and binding obligation of such Party and is enforceable against it in accordance with its terms,
subject to the effects of bankruptcy, 

  
  

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insolvency, or other similar laws of general application affecting the enforcement of creditor rights and judicial principles affecting the availability of specific performance and general
principles of equity, whether enforceability is considered a proceeding at law or equity. 
 (b) Except for the FDA’s
approval of Patheon’s manufacturing, testing, and packaging for the Product from the Manufacturing Suite, all necessary consents, approvals, and authorizations of all Regulatory Authorities, other governmental authorities, and other Persons
required to be obtained by such Party in connection with the execution and delivery of this Agreement and the performance of its obligations hereunder have been obtained. 

(c) The execution and delivery of this Agreement and the performance of such Party’s obligations hereunder (i) do
not and will not conflict with or violate any requirement of Applicable Law or any provision of the articles of incorporation, bylaws limited partnership agreement, or other constituent document of such Party and (ii) do not and will not
conflict with, violate, or breach, or constitute a default or require any consent under, any contractual obligation or court or administrative order by which such Party is bound. 

6.2 Additional Representations, Warranties and Covenants, of Patheon. Patheon warrants, represents and covenants, that: 

(a) (i) it has facilities, personnel, experience, and expertise sufficient in quality and quantity to perform the
obligations hereunder, (ii) it shall perform its obligations in conformity with GMPs where applicable, (iii) it will comply with the Quality Agreement and comply with all agreed upon quality assurance, quality controls, and review
procedures in the performance of its obligations hereunder and (iv) during the Term, the Facility will remain operational and qualified for the purpose of the Manufacture of Product under the terms of this Agreement; 

(b) it has, as of the Effective Date observed and complied, and shall, during the Term and at its cost (subject to Sections
2.9(b)-(d) and Section 3.7), observe and comply, with all then-current Applicable Laws, including federal, state, and local laws, orders, regulations, rules, customs, and ordinances now in force or that may hereafter be in force,
pertaining to the Facility and the performance of the Manufacturing Services and including, without limitation, (i) labor laws, orders, regulations, rules, customs, and ordinances of the country of Manufacture and (ii) those issued by the
FDA pertaining to the Manufacturing Services and the Facility (but not those pertaining solely to non-Manufacturing matters relating to the Product, compliance with which shall be the responsibility of Flexion), and any laws, orders, regulations,
rules, or ordinances issued in addition to, as a supplement to or as a replacement of Applicable Laws; 
 (c) none of it,
its Affiliates, nor any Person under its direction or control, has ever been, nor will it engage suppliers which have to its actual 

  
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knowledge, after due inquiry, been, (i) debarred or convicted of a crime for which a person can be debarred, under Section 335(a) or 335(b) of the FDA Act, or any equivalent Applicable
Law of the country of Manufacture, (ii) threatened to be debarred under the FDA Act or any equivalent Applicable Law of the country of Manufacture or (iii) indicted for a crime or otherwise (to its actual knowledge after due inquiry)
engaged in conduct for which a person can be debarred under the FDA or any equivalent Applicable Law of the country of Manufacture, and Patheon agrees that it will, within [...***...], notify Flexion in the event it receives notification of
any such debarment, conviction, threat or indictment. Should Patheon become aware of any actual or suspected noncompliance with the foregoing, Patheon will notify Flexion in writing of such issue within [...***...]. For the purpose of this
Section 6.2, suppliers and subcontractors engaged by Patheon to undertake the Manufacture of the Product shall be deemed to be under Patheon’s direction or control; 

(d) none of it, its Affiliates, nor any Person under its direction or control is currently excluded from a federal or state
health care program under Sections 1128 or 1156 of the Social Security Act, 42 U.S.C. §§ 1320a-7, 1320c-5 or any equivalent Applicable Law of the country of Manufacture, as may be amended or supplemented; 

(e) none of it, its Affiliates, nor any Person under its direction or control is otherwise currently excluded from contracting
with the U.S. federal government or the government of the country of Manufacture; 
 (f) none of it, its Affiliates, nor any
Person under its direction or control is otherwise currently excluded, suspended, or debarred from any U.S. or foreign governmental program; 

(g) it shall immediately notify Flexion if, at any time during the Term, Patheon, its Affiliates, or any Person under its
direction or control is convicted of an offense that would subject it or Flexion to exclusion, suspension, or debarment from any U.S. or foreign governmental program; and 

(h) agrees to keep the Equipment free form all liens and encumbrances. 

(i) it will not enter into any agreement or arrangement with any other Person that would prevent its ability to perform its
obligations hereunder. 
 6.3 Warranty. Patheon warrants that, at the time of delivery of Product to Flexion: (a) such Product
will have been Manufactured in accordance with the [...***...]; (b) such Product will be in conformity with the 

  
  

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[...***...] in accordance with the [...***...] set out therein and will conform with the [...***...] therefor provided pursuant to Section [...***...]; (c) title to
such Product will pass to Flexion as provided herein free and clear of any security interest, lien, or other encumbrance; (d) such Product will not be adulterated or misbranded within the meaning of the FDA Act as a result of a Patheon
Nonconformance; and (e) such Product will not be articles that, under the provisions of the FDA Act, may not be introduced into interstate commerce as a result of a Patheon Nonconformance. 

6.4 Additional Representations and Warranties of Flexion. Flexion warrants and represents that: 

(a) Non-Infringement. 

(i) (1) as of the Effective Date, it or its Affiliates Control all issued patents and pending patent applications set
forth on Schedule 6.4(a), which patents and applications are necessary for performance of the Manufacturing Services; and (2) it has the right to authorize Patheon to use and exploit such issued patents and pending patent applications to
perform the Manufacturing Services in accordance with the terms and conditions hereof; 
 (ii) as of the Effective Date, to
the actual knowledge of Flexion’s management team, having taken all Diligent and Reasonable Steps to ascertain the same, that there are no facts or circumstances that would cause Flexion to conclude that the performance of the Manufacturing
Services, in accordance with the terms and conditions hereof and using Flexion’s Manufacturing Process, or the manufacture, use, supply or other disposition of the Product by Patheon as may be required to perform its obligations under this
Agreement, will result, in the infringement or misappropriation of any Third Party’s intellectual property rights; 

(iii) as of the Effective Date, Flexion or its Affiliates Control and have the right to lawfully disclose the Specifications to
Patheon and to authorize Patheon to use the Specification to perform the Manufacturing Services; 
 (iv) as of the Effective
Date, there are no actions or other legal proceedings pending against Flexion and/or its Affiliates concerning the infringement of Third Party intellectual property rights related to any of the Specifications, Flexion’s Manufacturing Process,
any of the Materials, or the sale, use, or other disposition by Flexion of any Product made in accordance with the Specifications. 
 For
the purposes of part (ii) above, “Diligent and Reasonable Steps” means such steps as would normally be taken by a company of the same size and nature as Flexion for a product of 

  
  

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similar market potential at a similar stage of its product life, when utilizing sound and reasonable business practice. 

(b) Quality and Compliance. 

(i) during the Term, the Specifications for all Products conform to all applicable GMPs and Applicable Laws; 

(ii) during the Term, the Products, if labelled and manufactured in accordance with the Specifications and in compliance with
the Quality Agreement, applicable GMPs and Applicable Laws may be lawfully sold and distributed in every jurisdiction in which Flexion markets the Products; and 

(iii) during the Term, on the date of shipment to Patheon, any Flexion-Supplied Materials will conform to the specifications
for the Flexion-Supplied Materials that Flexion has given to Patheon and the Flexion-Supplied Materials will be adequately contained, packaged, and labelled and will conform to the affirmations of fact on the container. 

(c) Flexion agrees that, as a pre-condition to the adding of any country to the Territory pursuant to section 2.2(h), Flexion
shall repeat the warranties above as at the date on which the country is added to the Territory. 
 6.5 DISCLAIMER. THE FOREGOING
EXPRESS WARRANTIES SET FORTH IN THIS ARTICLE VI ARE IN LIEU OF ALL OTHER WARRANTIES, EXPRESS OR IMPLIED, INCLUDING ANY WARRANTY OF MERCHANTABILITY, OR FITNESS FOR A PARTICULAR PURPOSE, OR NONINFRINGEMENT, AND ALL OTHER WARRANTIES ARE HEREBY
DISCLAIMED AND EXCLUDED BY EACH PARTY. 
 6.6 Legal Compliance. 

(a) Patheon confirms that all licences, registrations and Regulatory Authority approvals to be obtained by Patheon pursuant to this Agreement
and the Technical Transfer Agreement shall be obtained in a lawful and ethical manner. 
 (b) Patheon has not and shall not cause Flexion or
its subsidiaries or affiliates to be in violation of any applicable U.S. export or import control or customs law or regulation, U.S. sanctions or embargoes, the U.S. Foreign Corrupt Practices Act of 1977 (as amended) (“FCPA”), the U.S.
Travel Act, the UK Bribery Act of 2010 (the “UK Bribery Act”), anti-corruption and anti-kickback laws and regulations, any applicable anti-corruption laws or regulations of another country, or any other applicable law or
regulation. In relation to Flexion’s business, Patheon has not and shall not directly or indirectly offer, pay, solicit, or accept any bribes, kickbacks, or other improper payments/benefits to or from any party, including, but not limited
to, any employee, representative, or official of the Flexion, any government, or any state-affiliated entity. Patheon has not and shall not offer, pay, solicit, or accept any rebates or refunds in connection with the Product

  
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or Flexion’s business without informing and obtaining the written approval of Flexion in advance and ensuring that such rebate/refund is compliant with all applicable laws and regulations.
Patheon has in good faith provided to Flexion accurate and complete due diligence information and materials regarding Patheon and its employees and Affiliates in response to requests by Flexion. In relation to the performance of this Agreement,
Patheon shall fully cooperate with Flexion in ensuring compliance with the FCPA, the UK Bribery Act and all other applicable laws and regulations.

(c) Flexion may suspend its performance under this Agreement if Flexion reasonably suspects that Patheon has or will violate the FCPA,
the UK Bribery Act or any other applicable law or regulation. Patheon shall reasonably cooperate with Flexion with any audit or questioning related thereto.

(d) Patheon understands and acknowledges that a violation of the FCPA, the UK Bribery Act or any of the terms of this Section 6.6 by
Patheon or its employees, agents, or contractors shall constitute a [...***...] for the purpose of Section [...***...] of this Agreement. 

ARTICLE VII. CONFIDENTIALITY 

7.1 Confidentiality Obligations. 

(a) Subject to the provisions of clauses (b), (c) and (d) below, at all times during the Term and for seven
(7) years following the expiration or termination thereof, the Receiving Party (i) shall keep completely confidential and shall not publish or otherwise disclose any Proprietary Information furnished to it by the Disclosing Party, except
to those of the Receiving Party’s Representatives or Affiliates to perform such Party’s obligations hereunder (and who shall be advised of the Receiving Party’s obligations hereunder and who are bound by confidentiality obligations
with respect to such Proprietary Information no less onerous than those set forth in this Agreement) and (ii) shall not use Proprietary Information of the Disclosing Party directly or indirectly for any purpose other than performing its
obligations or exercising its rights hereunder. The Receiving Party shall be jointly and severally liable for any breach by any of its Representatives of the restrictions set forth in this Agreement. 

(b) The Receiving Party’s obligations set forth in this Agreement shall not extend to any Proprietary Information of the
Disclosing Party: 

  
  

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 (i) that is or hereafter becomes part of the public domain by public use,
publication, general knowledge or the like through no wrongful act, fault or negligence on the part of a Receiving Party or its Representatives or Affiliates; 

(ii) that is received from a Third Party without restriction and without breach of any agreement between such Third Party and
the Disclosing Party; 
 (iii) that the Receiving Party can demonstrate by competent evidence was already in its possession
without any limitation on use or disclosure prior to its receipt from the Disclosing Party; 
 (iv) that is generally made
available to Third Parties by the Disclosing Party without restriction on disclosure; or 
 (v) that the Receiving Party can
demonstrate by competent evidence was independently developed by the Receiving Party without reference to the Proprietary Information of the Disclosing Party. 

(c) Each Party may disclose Proprietary Information to the extent that such disclosure is: 

(i) made in response to a valid order of a court of competent jurisdiction or other governmental body of a country or any
political subdivision thereof of competent jurisdiction; provided, however, that the Receiving Party shall first have given notice to the Disclosing Party and given the Disclosing Party a reasonable opportunity to quash such order and to obtain a
protective order requiring that the Proprietary Information and/or documents that are the subject of such order be held in confidence by such court or governmental body or, if disclosed, be used only for the purposes for which the order was issued;
and provided further that if a disclosure order is not quashed or a protective order is not obtained, the Proprietary Information disclosed in response to such court or governmental order shall be limited to that information which is legally
required to be disclosed in such response to such court or governmental order; 
 (ii) otherwise required by law or
regulation, including the rules and regulations of any securities authority or stock exchange on which such Party’s or its Affiliate’s securities are traded, as determined in good faith by counsel for the Receiving Party and acting in
accordance with Section 10.10; 
 (iii) made in connection with the filing or prosecution of patent rights as permitted
by this Agreement; 
 (iv) made in connection with the enforcement of such Party’s rights under this Agreement and in
performing its obligations under this Agreement; 
 (v) made in connection with the prosecution or defense of litigation as
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 (vi) made to Affiliates, actual and potential licensees and sublicensees,
employees, consultants or agents of the Receiving Party who have a need to know such information in order for the Receiving Party to exercise its rights or fulfill its obligations under this Agreement, provided, in each case, that any such
Affiliate, actual or potential licensee or sublicensee, employee, consultant or agent agrees to be bound by terms of confidentiality and non-use comparable in scope to those set forth herein; and 

(vii) made to Third Parties in connection with due diligence or similar investigations by such Third Parties, and disclosure to
potential Third Party investors in confidential financing documents, provided, in each case, that any such Third Party agrees to be bound by reasonable obligations of confidentiality and non-use; and 

(viii) with respect to disclosure by Flexion, made to Regulatory Authorities in connection with obtaining and maintaining any
Marketing Authorization. 
 (d) The Parties rights and obligations regarding the filing of this Agreement with any
securities authority or with any stock exchange on which securities issued by a Party or its Affiliate are traded are set forth in Section 10.10. 

(e) Subject to Patheon’s obligations with any Regulatory Authority, upon expiration or termination of this Agreement,
each Party, at the request of the other, shall return all data, files, records and other materials in its possession or control containing or comprising the other Party’s Proprietary Information; provided that each Party may retain a copy of
any Proprietary Information of the other Party required in order to permit a Party to exercise its rights pursuant to clause (c) above. 

7.2 Injunctive Relief. Each Party acknowledges that a breach by either Party of the this ARTICLE VII may not reasonably or adequately
be compensated in damages in an action at law and that such a breach may cause the other Party irreparable injury and damage. By reason thereof, each Party agrees that the other Party may be entitled, in addition to any other remedies it may have
under this Agreement or otherwise, to apply for preliminary and permanent injunctive and other equitable relief to prevent or curtail any breach of this ARTICLE VII; provided, however, that no specification in this Agreement of a specific legal or
equitable remedy will be construed as a waiver or prohibition against the pursuing of other legal or equitable remedies in the event of such a breach. Each Party agrees that the existence of any claim, demand, or cause of action of it against the
other Party, whether predicated upon this Agreement, or otherwise, will not constitute a defense to the enforcement by the other Party, or its successors or assigns, of the covenants contained in this ARTICLE VII. 

  
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 ARTICLE VIII. TERM AND TERMINATION 

8.1 Term. This Agreement shall commence as of the Effective Date and, unless earlier terminated in accordance with the terms hereof,
shall expire on the tenth (10th) anniversary of the FDA Approval Date (the “Initial Term”). Notwithstanding, by mutual agreement the Parties may commence discussions three
(3) years prior to the end of the Initial Term with a view to extending the Initial Term for such period or periods as may be agreed (collectively, the Initial Term and any extensions thereof, the “Term”). 

8.2 Termination. In addition to any other provision of this Agreement expressly providing for termination of this Agreement, this
Agreement may be terminated as follows: 
 (a) Flexion may terminate this Agreement: 

(i) at any time by giving Patheon one (1) month prior written notice in the event that for efficacy or safety reasons the
Product is withdrawn permanently or, if not yet approved, the Product is barred from further development (in either case for reasons outside of the reasonable control of Flexion) in the United States or any other market in a country or countries of
the Territory that represent eighty percent (80%) or more of Flexion’s overall Product sales including without limitation: (A) if any Regulatory Authority causes the clinical hold or permanent withdrawal of the Product,
(B) failure to receive Marketing Authorization in the United States, (C) failure of the Product to achieve its primary endpoint or key secondary endpoints with respect to either of the ongoing (as of the Effective Date) Phase 2(b) and
Phase 3 clinical trials, or (D) safety data which Flexion determines may have a materially adverse impact on use of the Product. 

(ii) for convenience, at any time (x) prior to the FDA Approval Date, with three (3) months written notice to
Patheon, and (y) after the FDA Approval Date, by giving twenty four (24) months prior written notice to Patheon; or 

(iii) at any time upon written notice in the event of any material default by Patheon in the performance of any of its
obligations hereunder, which material default has not been cured by Patheon within ninety (90) days after receiving written notice thereof (“Remediation Period”), provided that Patheon shall continue performing hereunder
pursuant to the terms of Section 8.4 below. Flexion’s right to terminate this Agreement for a particular breach under this Section 8.2(a)(iii) may only be exercised for a period of one hundred twenty (120) days following the
expiry of the Remediation Period (where the breach has not been remedied) and, if the termination right is not exercised during this period, then Flexion will be deemed to have waived its right to terminate this Agreement for such breach. For
purposes of clarity, the Parties agree that a “material default” of Patheon shall have occurred if (A) Patheon shall have delivered Non-Conforming Product caused by Patheon Nonconformance with respect to three (3) batches in any
one calendar year, or (B) the Facility and/or the Manufacturing 

  
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Suite violates GMP or other Applicable Law preventing the ability to continue the Manufacturing of Product for at least six (6) months. 

(b) Patheon may terminate this Agreement at any time upon written notice in the event of (i) any material default by
Flexion in the performance of any of its obligations hereunder, which default has not been cured by Flexion within ninety (90) days after receiving written notice thereof; or (ii) Flexion’s default of its payment obligations in
accordance with ARTICLE IV which default has not been cured by Flexion within fifteen (15) days after receiving written notice thereof; provided, however, that, if Flexion fails to cure such payment default, Patheon may not terminate without
first providing a second notice to the attention of Flexion’s Chief Executive Officer and an additional fifteen (15) day cure period. 

(c) This Agreement may be terminated at any time by either Party immediately upon written notice to the other Party
(A) pursuant to Section 10.2 in the event of a force majeure that remains uncured for the period provided in Section 10.2, or (B) if the other Party shall file in any court or agency, pursuant to any statute or regulation of any
state or country, a petition in bankruptcy or insolvency or for reorganization or for arrangement or for the appointment of a receiver or trustee of the other Party or of its assets, or if the other Party proposes a written agreement of composition
of its debts, or if the other Party shall be served with an involuntary petition against it, filed in any insolvency proceeding, and such petition is consented to by such Party or is not dismissed within sixty (60) days after the filing
thereof, or if the other Party shall propose or be a Party to any dissolution or liquidation, or if the other Party shall make an assignment for the benefit of its creditors. 

(d) Either Party may terminate this Agreement by giving three (3) months’ notice to the other Party if a permanent
injunction is granted pursuant to a Third Party claim for intellectual property infringement in either the United Kingdom and/or the United States preventing the further sale, promotion or marketing of the Product in such country as applicable. 

(e) This Agreement will automatically terminate should either Flexion or Patheon exercise its right to terminate the Technical
Transfer Agreement (but not in the event of an expiration of such agreement as set forth in Section 8.2 thereof) prior to the FDA Approval Date, in which case, any payment to Patheon will be made in accordance with the Technical Transfer
Agreement. 
 8.3 Effect of Termination. 

(a) The expiration or termination of this Agreement shall be without prejudice to any rights or obligations of the Parties
that may have accrued prior to such termination, and the provisions of Sections 2.8 (in respect of Product on the market at the date of termination of this Agreement), 3.5, 3.6, 3.8, 3.10, 3.12, 3.13, 5.1, 5.2(c), 5.5, 6.3, 6.5, 8.3 and 8.4 and
ARTICLE I (to the extent definitions are used in other surviving sections pursuant to this Section 8.3(a)), ARTICLE IV, 

  
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 ARTICLE VII, ARTICLE IX, and ARTICLE X; provided that, Section 3.8 shall only survive for a
period of [...***...] days after expiration or termination of this Agreement in respect of deviations that occurred before termination or expiration and continue to be relevant shall survive the expiration or termination of this
Agreement. Except as otherwise expressly provided herein, termination of this Agreement in accordance with the provisions hereof shall not limit remedies that may otherwise be available in law or equity. 

(b) Upon expiration or termination of this Agreement, subject to the Parties’ obligations under Section 8.4 below,
each Party, at the request of the other, shall return all data, files, records, and other materials in its possession or control containing or comprising the other Party’s Proprietary Information. 

(c) Upon expiration or termination of this Agreement for any reason, subject to the Parties’ obligations under
Section 8.4 below, (i) all submitted but unfilled Purchase Orders with respect to which Patheon has (1) not begun Manufacture of Product shall be cancelled, or (2) begun Manufacture of the Product shall be completed, unless
otherwise agreed (ii) Flexion shall remove all Flexion Manufacturing Equipment and Materials from the Facility within [...***...] days of such termination under all sections other than Section 8.2(a)(iii) and within [...***...]
days [...***...] of a termination by Flexion pursuant to Section 8.2(a)(iii) that is not reasonably disputed by Patheon, failing which Flexion will pay a fee equivalent to the aggregate monthly Base Fee for the Manufacturing Suite for
each month or part month the Flexion Manufacturing Equipment or Materials remain at the Facility after [...***...] days or [...***...] days, as applicable, from such termination. 

(d) Upon expiration or termination of this Agreement, subject to the Parties’ obligations under Section 8.4 below,
(i) Flexion shall purchase from Patheon at Patheon’s cost, all unpaid Material Costs and Bill Back Items which were ordered, purchased, produced or maintained by Patheon in contemplation of the Manufacture of the Product in accordance with
Section 2.2; (ii) Flexion shall pay Patheon any earned but unpaid Product Fees, including those under any outstanding Purchase Order as described in Section 8.3(c); (iii) Flexion shall pay for any earned (through the month of
such expiration or termination) but undisputed and unpaid Base Fees, Phase I Filling Space Fees or Additional Services; and (iv) Flexion shall pay all due and outstanding invoices under ARTICLE IV. 

(e) Upon expiration or termination of this Agreement for any reason other than by [...***...] pursuant to Section
[...***...] that is not reasonably disputed by [...***...], subject to the Parties’ obligations under Section 8.4 below, Flexion shall pay to Patheon all and any removal and Make Good Costs associated with the removal of the
Flexion Manufacturing Equipment 

  
  

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from the Facility as agreed to in good faith by the Parties. “Make Good Costs” means the reasonable costs required to repair the Facility and return it to a clean, safe and
useable area based on the repair of damage caused by the installation or removal of Flexion Manufacturing Equipment. In relation to termination of this Agreement by [...***...] pursuant to Section [...***...], Flexion shall pay any
Make Good Costs that are required in relation to and to the extent that any damage that is caused to the Facility as a result of the negligence of Flexion or its agent or a failure to materially comply with the reasonable written instructions of
Patheon in the removal of Flexion Manufacturing Equipment. 
 (f) The Parties understand and believe that the expiration or
termination of this Agreement for any reason shall not constitute a “relevant transfer” as defined by and pursuant to Regulation 3(1)(b) of the Transfer of Undertakings (Protection of Employment) Regulations 2006 (“TUPE”).
If, contrary to the Parties’ understanding and belief, TUPE does apply on the expiration or termination of this Agreement to the transfer of any employee or subcontractor of Patheon to Flexion or to any person who, after expiration or
termination of this Agreement, provides to Flexion services similar to the Manufacturing Services and/or the Additional Services (“Replacement Entity”) then: 
  

	 	(i)	without prejudice to Flexion’s obligations under Section 8.3(g) below, following termination or expiry of this Agreement other than by [...***...] pursuant to Section [...***...], Flexion shall
indemnify Patheon for and against all claims, costs, expenses or liabilities arising, incurred or suffered by Patheon in relation to any claim made by or in respect of any person employed or formerly employed by Patheon for which it is alleged
Flexion and/or any Replacement Entity may be liable by virtue of TUPE, provided that this indemnity shall not apply if and to the extent that, (A) the aggregate amount payable by Flexion pursuant to this Section 8.3(f)(i) and
Section 8.3(g) exceeds the Maximum Manufacturing Services Termination Costs; or (B) any such claim, cost, expense or liability arises as a result of a failure by Patheon to comply with its applicable obligations under TUPE.

  

	 	(ii)	 if (A) this Agreement has been terminated by [...***...] pursuant to Section [...***...], or (B) this Agreement terminates or
expires under any other circumstances and the aggregate amount payable by Flexion pursuant to Section 8.3(f)(i) and Section 8.3(g) exceeds the Maximum Manufacturing Services Termination Costs, Patheon shall indemnify Flexion for and
against all claims, costs, expenses or liabilities arising, incurred or suffered by Flexion and/or any Replacement Entity in relation to any claim 

  
  

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made by or in respect of any person employed or formerly employed by Patheon for which it is alleged Flexion and/or any Replacement Entity may be liable by virtue of TUPE provided that this
indemnity shall not apply if and to the extent that any such claim, cost, expense or liability arises as a result of a failure by Flexion or the Replacement Entity to comply with its applicable obligations under TUPE. 

(g) Subject to the Parties’ obligations under Section 8.4 below, Flexion shall pay to Patheon the following costs
(“Manufacturing Services Termination Costs”): (i) upon expiration or termination of this Agreement, all reasonable actual costs incurred by Patheon to complete activities associated with such completion, expiry or termination
including, without limitation, disposal fees that may be payable for any Materials and supplies owned by Flexion to be disposed of by Patheon; and (ii) upon expiration or termination of this Agreement other than by
[...***...] pursuant to Section [...***...], all and any direct costs and expenses or termination or cancellation fees payable by Patheon as a consequence of or arising from the termination of this Agreement, to include but not
limited to, all and any reasonable redundancy costs of employees employed by Patheon to work solely or mainly in providing the Services and/or Manufacturing the Product, all and any termination costs in relation to subcontractors and agency staff
working solely or mainly in providing the Services and/or Manufacturing the Product and any termination or cancellation fees payable to Third Party suppliers. Patheon will use commercially reasonable efforts to mitigate the Manufacturing Services
Termination Costs and reallocate available resources. Patheon will further provide Flexion with documentation in order to substantiate the Manufacturing Services Termination Costs. Notwithstanding anything in this Section 8.3(g), Flexion’s
aggregate liability for the Manufacturing Services Termination Costs (under both this Agreement and the Technical Transfer Agreement combined) shall be limited to the payment to Patheon of the first £[...***...] (the “Maximum
Manufacturing Services Termination Costs”). 
 (h) Flexion acknowledges that no Patheon Competitor (being a Person
that derives greater than [...***...]% of its revenues from performing contract pharmaceutical or biopharmaceutical development or commercial manufacturing services) will be permitted access to the Facility. 

(i) In relation to any representatives of Flexion that are permitted access to the Facility pursuant to Section 8.3 or
8.4, Flexion shall ensure that such representatives are appropriately trained by Flexion (e.g. GMP training) and shall 

  
  

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observe at all times Patheon’s policies and procedures (as amended from time-to-time) as they pertain to the Facility, including policies relating to health and safety and compliance with
GMP, and comply with all reasonable directions of Patheon in relation to the same; provided that Flexion is given notice of such policies and given a reasonable period of time to review and implement such policies. Patheon may refuse or limit in its
sole discretion at any time admission to the Facility by any of Flexion’s representatives who fail to observe such policies or comply with such reasonable directions. 

(j) The Parties agree that if any fees or charges are duplicated under Section 8.11 of the Technical Transfer Agreement,
Flexion shall only be obligated to make such payment once. 
 8.4 Transition Assistance. 

(a) Upon the delivery by either Party of a notice of termination of this Agreement for any reason, upon the request of
Flexion, and subject to terms set forth in this Agreement including this Section 8.4(a), (i) Patheon shall provide Flexion with the reasonable assistance of its staff and reasonable access to its other internal resources to provide Flexion
with a reasonable level of technical assistance and consultation to transfer the Manufacture and the regulatory qualification of the Product to a supplier of Flexion’s election, provided that Flexion will reimburse Patheon for its fees and all
documented costs and out-of-pocket expenses incurred in connection with such assistance (Patheon would provide a quotation for the services which Flexion requires pursuant to this Section 8.4 as Additional Services and on acceptance by Flexion
of the same, Patheon will provide the services stated therein) and (ii) Patheon will provide the deliverables set forth on Schedule 8.4(a) hereto subject to payment of the fees and costs to be paid by Flexion as described above. 

(b) Upon the delivery by [...***...] of a notice of termination of this Agreement pursuant to Section [...***...]
(but not including the giving of notice of termination following an extension to this Agreement pursuant to this Section 8.4(b)), if requested by Flexion in writing given at the same time as the giving of such notice of termination including
the term of such additional supply, Patheon shall supply the Products pursuant to the terms of this Agreement for a period not to exceed a maximum of [...***...] from the delivery of a notice of termination. For the avoidance of doubt, the
termination date of this Agreement shall be deemed the date upon which the Parties have completed their obligations under this Section 8.4. Flexion acknowledges that, during such transition assistance period, no Patheon Competitor (being a
Person that derives greater than [...***...]% of its revenues from performing contract pharmaceutical or biopharmaceutical development or commercial manufacturing services) will be 

  
  

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permitted access to portions of the Facility other than those dedicated to the Manufacture of the Product. 

ARTICLE IX. INDEMNIFICATION 

9.1 Flexion Indemnification Obligations. Flexion shall indemnify Patheon, its Affiliates, and their respective directors, officers,
employees, and agents (the “Patheon Indemnified Parties”), and defend and save each of them harmless, from and against any and all (a) Third Party Losses incurred by any of them in connection with, arising from, or occurring as
a result of (i) the breach by Flexion of any of its obligations under this Agreement; (ii) the breach or inaccuracy of any representation or warranty made by Flexion in this Agreement, (iii) any negligence or willful misconduct by
Flexion or any of its Affiliates, (iv) any claim made by any Person that the Manufacture and supply of the Product in accordance with the terms hereof infringes or misappropriates the patent, trademark, or other intellectual property rights of
such Person, and (v) any product liability claim made by any Person with respect to any Product Manufactured in accordance with the terms hereof, except to the extent liability is based on a Patheon Nonconformance or (b) any Loss incurred
by any of them as a direct result of and to the extent of the negligence or willful misconduct of the Flexion On Site Representatives at the Facility except, in each case, for those Losses for which Patheon has an obligation to indemnify the Flexion
Indemnified Parties pursuant to Section 9.2, as to which Losses each Party shall indemnify the other to the extent of their respective liability for such Losses and provided, however, that Flexion will not be required to indemnify the Patheon
Indemnified Parties with respect to any such Loss hereunder to the extent the same is caused by any breach of contract, negligent act or omission, or intentional misconduct by any Patheon Indemnified Parties. For the avoidance of doubt, the parties
acknowledge that Patheon has not and will not conduct any freedom to operate searches in relation to the Product and/or Flexion’s Manufacturing Process nor reviewed any third party patents in relation thereto and that Patheon’s failure or
omission to do so will not be considered negligence for the purposes of excluding or limiting a claim under this indemnity. 
 9.2
Patheon Indemnification Obligations. Patheon shall indemnify Flexion, its Affiliates, and their respective directors, officers, employees, and agents (the “Flexion Indemnified Parties”), and defend and save each of them
harmless, from and against any and all (a) Third Party Losses incurred by any of them resulting from, or relating to, any claim of personal injury or property damage to the extent that the injury or damage is in connection with, arising from,
or occurring as a result of (i) the breach or inaccuracy of any representation or warranty made by Patheon in this Agreement, (ii) any negligence or willful misconduct by Patheon or any of its Affiliates; and (iii) any product
liability claim made by any Person with respect to any Product Manufactured by Patheon to the extent any such liability is based on or caused by a Patheon Nonconformance; (b) Third Party Losses incurred by any of them in connection with,
arising from, or occurring as a result of a claim that any Existing Patheon Intellectual Property or Patheon Improvement used by Patheon in its Manufacture of the Product infringes or misappropriates the patent, trademark, or other intellectual
property rights of such Person; except, in each case, for which Flexion has an obligation to indemnify the Patheon Indemnified Parties pursuant to Section 9.1, as to which Losses each Party shall indemnify the other to the extent of their
respective liability for such Losses and provided, however, that Patheon will not be required to indemnify the Flexion Indemnified Parties with respect to any 

  
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such Loss hereunder to the extent the same is caused by any breach of contract, negligent act or omission, or intentional misconduct by Flexion Indemnified Parties. 

9.3 Indemnification Procedure. 

(a) Notice of Claim. The indemnified Party (the “Indemnified Party”) shall give the indemnifying Party
(the “Indemnifying Party”) prompt written notice (an “Indemnification Claim Notice”) of any Loss, action, or discovery of facts upon which such Indemnified Party intends to base a request for indemnification under
Section 9.1 or 9.2 (a “Claim”), but in no event shall the Indemnifying Party be liable for any Losses that result from any delay in providing such notice. Each Indemnification Claim Notice must contain a description of the
claim and the nature and amount of such Loss (to the extent that the nature and amount of such Loss are known at such time). The Indemnified Party shall furnish promptly to the Indemnifying Party copies of all papers and official documents received
in respect of any Losses upon which it intends to seek indemnification. 
 (b) Control of Defense. At its option, the
Indemnifying Party may assume the defense of any Claims by giving written notice to the Indemnified Party within [...***...] days after the Indemnifying Party’s receipt of an Indemnification Claim Notice; provided that the assumption of
the defense of a Claim by the Indemnifying Party shall not be construed as an acknowledgment that the Indemnifying Party is liable to indemnify any Indemnified Party in respect of the Claim, nor shall it constitute a waiver by the Indemnifying Party
of any defenses it may assert against any Indemnified Party’s Claim. Upon assuming the defense of a Claim, the Indemnifying Party may appoint as lead counsel in the defense of such Claim any legal counsel selected by the Indemnifying Party. In
the event the Indemnifying Party assumes the defense of a Claim, the Indemnified Party shall immediately deliver to the Indemnifying Party all original notices and documents (including court papers) received by any Indemnified Party in connection
with the Claim. Subject to clause (c) below, if the Indemnifying Party assumes the defense of a Claim, the Indemnifying Party shall not be liable to the Indemnified Party for any legal expenses subsequently incurred by such Indemnified Party in
connection with the analysis, defense, or settlement of such Claim. In the event that it is ultimately determined that the Indemnifying Party is not obliged to indemnify, defend, or hold harmless an Indemnified Party from and against any Claim, the
Indemnified Party shall reimburse the Indemnifying Party for any and all costs and expenses (including attorneys’ fees and costs of suit) and any Losses incurred by the Indemnifying Party in its defense of such Claim. 

(c) Right to Participate in Defense. Without limiting Section 9.3(b), any Indemnified Party shall be entitled to
participate in, but not control, the defense of a Claim and to employ counsel of its choice for such purpose; provided, 

  
  

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however, that such employment shall be at the Indemnified Party’s own expense unless (i) the employment thereof has been specifically authorized by the Indemnifying Party in writing,
(ii) the Indemnifying Party has failed to assume the defense and employ counsel in accordance with Section 9.3(b) (in which case the Indemnified Party shall control the defense), or (iii) the interests of the Indemnified Party and the
Indemnifying Party with respect to such Claim are sufficiently adverse to prohibit the representation by the same counsel of both Parties under Applicable Law, ethical rules, or equitable principles. 

(d) Settlement. With respect to any Losses (i) relating solely to the payment of money damages in connection with
a Claim, (ii) that will not result in the Indemnified Party becoming subject to injunctive or other relief or otherwise adversely affect the business or reputation of the Indemnified Party in any manner, and (iii) as to which the
Indemnifying Party has acknowledged in writing the obligation to indemnify the Indemnified Party hereunder, the Indemnifying Party shall have the sole right to consent to the entry of any judgment, enter into any settlement, or otherwise dispose of
such Loss, on such terms as the Indemnifying Party, in its sole discretion, shall deem appropriate. With respect to all other Losses in connection with Claims, where the Indemnifying Party has assumed the defense of the Claim in accordance with
Section 9.3(b), the Indemnifying Party shall have authority to consent to the entry of any judgment, enter into any settlement, or otherwise dispose of such Loss; provided that it obtains the prior written consent of the Indemnified Party,
which consent shall not be unreasonably withheld or delayed. The Indemnifying Party shall not, without the prior written consent of the Indemnified Party, agree to any settlement or acquiesce to any judgment with respect to a Claim that obligates
the Indemnified Party to pay any amount subject to indemnification by the Indemnifying Party or causes the Indemnified Party to admit to any civil or criminal liability. 

(e) Cooperation. If the Indemnifying Party chooses to defend or prosecute any Claim, the Indemnified Party shall
cooperate in the defense or prosecution thereof and shall, at the Indemnifying Party’s expense, furnish such records, information, and testimony, provide such witnesses, and attend such conferences, discovery proceedings, hearings, trials, and
appeals as may be reasonably requested in connection therewith. Such cooperation shall include access during normal business hours afforded to the Indemnifying Party to, and reasonable retention by the Indemnified Party of, records and information
that are reasonably relevant to such Claim, and making employees and agents available on a mutually convenient basis to provide additional information and explanation of any material provided hereunder, and the Indemnifying Party shall reimburse the
Indemnified Party for all its time and reasonable out-of-pocket expenses in connection therewith. 
 (f) Expenses.
Except as provided above, the reasonable and verifiable costs and expenses, including fees and disbursements of counsel, incurred by the Indemnified Party in connection with any Claim shall be reimbursed on a monthly basis in arrears by the
Indemnifying Party, without prejudice to the 

  
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Indemnifying Party’s right to contest the Indemnified Party’s right to indemnification and subject to refund in the event the Indemnifying Party is ultimately held not to be obliged to
indemnify the Indemnified Party. 
 9.4 Insurance. During the Term and for [...***...] thereafter, each Party shall procure
and maintain at its own expense from a qualified and licensed insurer liability insurance or indemnity policies, in an amount not less than $[...***...] in the aggregate with respect to public and products liability, subject to such deductible
or self-retention limits as either Party in its business discretion may elect. Such policies shall insure against liability on the part of each Party and any of its Affiliates, as their interests may appear, due to injury, disability, or death of
any person or persons, or injury to property, arising from the distribution of the Products. Each Party will either (a) include the other Party and its officers and employees and consultants as additional insureds on such policies, or
(b) ensure that such policy contains an indemnity to principal clause. Promptly following the execution of this Agreement, each Party shall provide to the other a certificate of insurance (i) summarizing the insurance coverage and
(ii) identifying any exclusions. Each Party shall promptly notify the other of any material adverse alterations to the terms of this policy or decreases in the amounts for which insurance is provided. 

9.5 Limitation on Damages 

(a) Maximum Liability. Except with respect to (i) [...***...] of Patheon or (ii) for damages incurred
by Flexion arising from, or occurring as a result of a claim by a Third Party that any [...***...] used by Patheon in its Manufacture of the Product [...***...] or (iii) breaches of [...***...], Patheon’s maximum
liability to Flexion under this Agreement for any reason whatsoever, including, without limitation, any liability arising under Sections 2.7, 2.8, 3.10, 3.12 or 9.2 hereof or resulting from any and all breaches of its representations, warranties, or
any other obligations under this Agreement in each calendar year (liability cap pro-rated for part calendar years) will not exceed [...***...]% of the revenues received by Patheon pursuant to this Agreement in the [...***...] period
prior to the month in which the underlying event occurred that gave rise to the liability (e.g. the date of the incident or manufacture). 

(b) NEITHER PARTY SHALL BE LIABLE TO THE OTHER FOR (I) ANY (DIRECT OR INDIRECT) LOSS OF PROFITS, OF PRODUCTION, OF
ANTICIPATED SAVINGS, OF BUSINESS, OF GOODWILL OR OF USE OF THE PRODUCT OR COSTS OF ANY SUBSTITUTE SERVICES OR (II) ANY OTHER LIABILITY, DAMAGE, COST OR EXPENSE OF ANY KIND INCURRED BY THE OTHER PARTY OF AN INDIRECT OR CONSEQUENTIAL NATURE,
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NOTICE OF THE POSSIBILITY OF THE DAMAGES. NOTWITHSTANDING THE FOREGOING, NOTHING IN THIS PARAGRAPH IS INTENDED TO LIMIT OR RESTRICT DAMAGES AVAILABLE FOR [...***...]. 

(c) The limitations set forth in Sections 9.5(a) and 9.5(b) shall not act to exclude or limit either Party’s liability
for (i) personal injury or death caused by the negligence of that Party, or for (ii) fraudulent misrepresentation. 

(d) Sole & Exclusive Remedies. Notwithstanding anything in this Article IX to the contrary: 

(i) Except as described in Section 9.5(c) above and except for Patheon’s indemnification obligations set forth in
Section 9.2, Patheon’s sole liability and Flexion’s sole and exclusive remedy whether in contract, tort, equity or otherwise for Non-Conforming Product based on or caused by a Patheon Nonconformance shall be the rights and remedies
set forth in Section 2.8, 3.10 and 3.12 of this Agreement and in Section 8.2(a)(iii) of this Agreement. 
 (ii)
Patheon’s sole liability and Flexion’s sole and exclusive remedy whether in contract, tort, equity or otherwise for Patheon’s failure to Manufacture the full quantity of Product specified in a Purchase Order by the Agreed Delivery
Date shall be the rights and remedies set forth in Section 2.7 and Section 8.2(a)(iii) of this Agreement. 
 9.6 Product
Liability Claims. As soon as it becomes aware, each Party will give the other prompt written notice of any defect or alleged defect in a Product, any injury alleged to have occurred as a result of the use or application of the Product, and any
circumstances that may give rise to litigation or recall of a Product or regulatory action that may affect the sale or Manufacture of a Product, specifying, to the extent the Party has such information, the time, place, and circumstances thereof and
the names and addresses of the persons involved. Each Party will also furnish promptly to the other copies of all papers received in respect of any claim, action, or suit arising out of such alleged defect, injury, or regulatory action. 

9.7 Allocation of Risk. This Agreement (including, without limitation, this ARTICLE IX) is reasonable and creates a reasonable
allocation of risk for the relative profits the Parties each expect to derive from the Products. 
 ARTICLE X. MISCELLANEOUS 

10.1 Notices. Notwithstanding that advance notification of any notices or other communications may be given by electronic mail
transmission, all notices or other communications that shall or may be given pursuant to this Agreement shall be in writing 

  
  

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(including by confirmed receipt electronic mail) and shall be deemed to be effective (a) when delivered if sent by registered or certified mail, return receipt requested, or (b) on the
next business day, if sent by overnight courier, (c) when sent if sent by electronic mail provided that receipt is confirmed, in each case to the Parties at the following addresses (or at such other addresses as shall be specified by like
notice) with postage or delivery charges prepaid: 
 If to Flexion: 

Flexion Therapeutics, Inc. 

Attn: Michael Clayman, MD 

Telephone: [...***...] 

Email: [...***...] 

With a copy to: Legal 
 If to
Patheon: 
 Attention: 

Patheon UK Limited 

Executive Director & General Manager 

Kingfisher Drive, Covingham 

Swindon, Wiltshire SN3 5BZ 

England 

Email: [...***...] 

with copy to 

Legal Director. 

10.2 Force Majeure. Neither Party shall be liable for delay in delivery, performance or nonperformance, in whole or in part, nor shall
the other Party have the right to terminate this Agreement except as otherwise specifically provided in this Section 10.2 where such delay in delivery, performance or nonperformance results from acts beyond the reasonable control and without
the fault or negligence of such Party including, but not limited to, the following conditions: fires, floods, storms, embargoes, shortages, epidemics, quarantines, war, acts of war (whether war be declared or not), terrorism, insurrections, riots,
civil commotion, or acts, omissions, or delays in acting by any governmental authority; provided that the Party affected by such a condition shall, within five (5) days of its occurrence, give notice to the other Party stating the nature of the
condition, its anticipated duration, and any action being taken to avoid or minimize its effect. The suspension of performance shall be of no greater scope and no longer duration than is reasonably required, and the nonperforming Party shall use its
commercially reasonable efforts to remedy its inability to perform; provided, however, that in the event the suspension of performance continues for [...***...] days after the date of the occurrence, and such failure to perform would
constitute a material breach of this Agreement in the absence of such force majeure event, the non-affected Party may terminate this Agreement immediately by written notice to the affected Party. 

  
  

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 10.3 Independent Contractor. The Parties to this Agreement are independent contractors.
Nothing contained in this Agreement shall be construed to place the Parties in the relationship of employer and employee, partners, principal, and agent or a joint venture. Neither Party shall have the power to bind or obligate the other Party nor
shall either Party hold itself out as having such authority. 
 10.4 Waiver. Save where expressly stated in Sections 2.8 and
8.2(a)(iii), no waiver by either Party of any provision or breach of this Agreement shall constitute a waiver by such Party of any other provision or breach, and no such waiver shall be effective unless made in writing and signed by an authorized
representative of the Party against whom waiver is sought. No course of conduct or dealing between the Parties will act as a modification or waiver of any provision of this Agreement. Either Party’s consent to or approval of any act of the
other Party shall not be deemed to render unnecessary the obtaining of that Party’s consent to or approval of any subsequent act by the other Party. 

10.5 Entire Agreement. This Agreement (together with all Exhibits and Schedules hereto, which are hereby incorporated by reference),
the Quality Agreement, and the Technical Transfer Agreement constitute the final, complete, and exclusive agreement between the Parties relating to the subject matter hereof and supersede all prior conversations, understandings, promises, and
agreements relating to the subject matter hereof, including without limitation that (i) certain Confidentiality Agreement dated September 22, 2014 between Flexion and Patheon and the Letter Agreement, and (ii) that certain Patheon
Partner External User Account/Access Form, Client Agreement and Authorization signed by Flexion on June 5, 2015. 
 Neither Party has
relied upon any communications, representations, terms or promises, verbal or written, not set forth herein. No terms, provisions or conditions of any purchase order or other business form or written authorization used by Flexion or Patheon will
have any effect on the rights, duties, or obligations of the Parties under or otherwise modify this Agreement, regardless of any failure of Flexion or Patheon to object to the terms, provisions, or conditions unless the document specifically refers
to this Agreement and is signed by both Parties. 
 10.5A Assignment; Change of Control. This Agreement may not be assigned by
Patheon without the prior written consent of Flexion. Notwithstanding the foregoing, either Party may assign this Agreement to an Affiliate or to an acquirer or successor in interest in connection with a Change of Control of such Party without the
prior written consent of the other Party, provided that such Party provides the other Party with written notice of any such assignment. This Agreement shall be binding upon and inure to the benefit of Flexion and Patheon and their respective
successors, heirs, executors, administrators, and permitted assigns. “Change of Control” means the closing of (a) a merger, consolidation or similar transaction providing for the acquisition of the direct or indirect ownership
of more than fifty percent (50%) of a Party’s shares or similar equity interests or voting power of the outstanding voting securities or that represents the power to direct the management and policies of such Party (including any
acquisition arising through the offering of any shares of Patheon or any of its Affiliates on any securities or stock exchange), or (b) the sale of all or substantially all of a Party’s assets related to the subject matter of the
Agreement. 

  
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 10.6 Amendment; Modification. This Agreement may not be amended, modified, altered, or
supplemented except by a writing signed by both Parties. No modification of any nature to this Agreement and no representation, agreement, arrangement, or other communication shall be binding on the Parties unless such is expressly contained in
writing and executed by the Parties as an amendment to this Agreement. This Agreement may not be amended in any respect by any purchase order, invoice, acknowledgment, or other similar printed document issued by either Party. 

10.7 Governing Law 
 (a)
The laws of [...***...], whether procedural or substantive (but excluding application of any choice of law provisions contained therein) shall apply to all matters pertaining only to (a) title to and ownership of Materials, Equipment or
the Facility, and its appurtenances including, without limitation, all rights therein and the creation, exercise and extinction of such rights, obligations and liabilities or (b) employment law matters. In relation to such matters, both Parties
shall submit to the exclusive jurisdiction of the [...***...] Courts. For the avoidance of doubt, the Parties agree that nothing in this Agreement shall (i) grant Flexion any property ownership rights in the Facility or (ii) shall
constitute a lease to the Facility. 
 (b) In all other respects, this Agreement shall be construed under and governed by the laws of
[...***...] without regard to the application of principles of conflicts of law. In relation to such matters, both Parties shall submit to the exclusive jurisdiction of [...***...]. 

(c) Any preliminary issue over which of sub-section 10.7(a) or (b) applies to a particular claim or dispute shall be determined in
accordance with provisions of 10.7(a). 
 (d) The Parties expressly exclude the application of the United Nations Convention on Contracts
for the International Sale of Goods, if applicable. 
 10.8 Compliance with Applicable Laws. Each Party and its Affiliates, and
their respective representatives, shall comply with all applicable laws, rules and regulations in the performance of their obligations under this Agreement. Without limiting the foregoing, each Party and its Affiliates, and their respective
representatives, shall comply with export control laws and regulations of the country of Manufacture and of the United States. Neither Party nor its Affiliates (or representatives) shall, directly or indirectly, without prior U.S. government
authorization, export, re-export, or transfer the Product to any country subject to a U.S. trade embargo, to any resident or national of any country subject to a U.S. trade embargo, or to any person or entity listed on the “Entity List” or
“Denied Persons List” maintained by the 

  
  

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U.S. Department of Commerce or the list of “Specifically Designated Nationals and Blocked Persons” maintained by the U.S. Department of Treasury. In so far as the same applies to a
Party or its Affiliates, each Party and its Affiliates and respective representatives shall comply with the requirements of the Foreign Corrupt Practices Act of 1977 (15 U.S.C. § 78dd-1, et seq.). 

10.9 Dispute Resolution. 

(a) The Parties recognize that disputes may arise from time to time during the Term of this Agreement. It is the objective of the Parties to
establish procedures to facilitate the resolution of such disputes arising under this Agreement in an expedient manner by mutual cooperation. To accomplish this objective, the Parties agree to follow the procedures set forth in this
Section 10.9 if and when a dispute arises under this Agreement. 
 (b) Unless otherwise specifically recited in the Agreement, disputes
between the Parties under this Agreement will be first referred to the Project Manager of each Party as soon as reasonably possible after such dispute has arisen. If the Project Managers are unable to resolve such a dispute within fifteen
(15) days of being requested by a Party to resolve such dispute, either Party may, by written notice to the other, have such dispute referred to the Steering Committee. If the Steering Committee is unable to resolve such dispute within thirty
(30) days of being requested by a Party to resolve such dispute, each Party shall have the right, pursuant to written notice, to refer such dispute to the [...***...] of each Party for attempted resolution by negotiations within thirty
(30) days after such written notice is received. If the [...***...] are unable to resolve such dispute within thirty (30) days of being requested by a Party to resolve such dispute, each Party shall have the right to pursue any
remedies available to it at law or in equity. 
 10.10 Securities Authorities and Stock Exchange Filings; Press Releases;
Use of Trademarks. 
 (a) The Parties shall coordinate in advance with each other in connection with (i) a Party’s decision to
file this Agreement with any securities authority or with any stock exchange on which securities issued by a Party or its Affiliate are traded, or (ii) any other disclosure of information pertaining to this Agreement as otherwise required by
the rules and regulations of the Securities and Exchange Commission or any other securities authority or stock exchange on which securities issued by a Party or its Affiliates are traded, and, in each such instance, (a) the filing Party will
provide the other Party at least ten (10) business days to review a draft redacted version of this Agreement, and (b) both Parties shall work together in good faith to agree on the disclosure to be made, having due and proper regard to
their legal obligations; provided that the filing Party subject to such rules and regulations shall ultimately retain control over what information to disclose to any securities authority or stock exchange. Each filing Party shall use reasonable
efforts to seek confidential treatment for terms proposed to be redacted; provided that the Parties shall use their reasonable efforts to file redacted versions with any governing bodies which are consistent with redacted versions previously filed
with any other governing bodies. 

  
  

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Other than such obligations, neither Party (nor any of its Affiliates) shall be obligated to consult with or obtain approval from the other Party with respect to any filings to any securities
authority or stock exchange. 
 (b) Except for the filings described in Section 10.10(a) above, the Parties agree not to disclose in
any press release or other public statement any terms or conditions of this Agreement to any Third Party without the prior consent of the other Party. Neither Party shall (a) issue a press release or make any other public statement that
references this Agreement or (b) use the other Party’s or the other Party’s Affiliates’ names or trademarks for publicity or advertising purposes, except with the prior written consent of the other Party. Each Party agrees that
it shall cooperate fully and in a timely manner with the other with respect to all disclosures to the Securities and Exchange Commission or any other governmental or regulatory agencies, including requests for confidential treatment of Proprietary
Information of either Party included in any such disclosure. 
 10.11 Severability. If any provision of this Agreement is found by a
proper authority to be unenforceable, that provision to the extent it is found to be unenforceable or invalid shall be severed and the remainder of the provision and this Agreement will continue in full force and effect. The Parties shall use their
best efforts to agree upon a valid and enforceable provision as a substitute for any invalid or unenforceable provision, taking in to account the Parties’ original intent of this Agreement. 

10.12 Construction. Unless the context of this Agreement otherwise requires: (a) words of any gender include each other gender;
(b) words using the singular or plural number also include the plural or singular number, respectively; (c) the terms “hereof,” “herein,” “hereby,” and derivative or similar words refer to this entire
Agreement; (d) the terms “Article,” “Section,” “Exhibit,” “Schedule,” or “clause” refer to the specified Article, Section, Exhibit, Schedule, or clause of this Agreement; (e) “or”
is disjunctive but not necessarily exclusive; and (f) the term “including” or “includes” means “including without limitation” or “includes without limitation.” Whenever this Agreement refers to a number
of days, such number shall refer to calendar days unless business days are specified. The captions and headings of this Agreement are for convenience of reference only and in no way define, describe, extend, or limit the scope or intent of this
Agreement or the intent of any provision contained in this Agreement. The language of this Agreement shall be deemed to be the language mutually chosen by the Parties, and no rule of strict construction shall be applied against either Party hereto.

 10.13 Third Party Beneficiaries. This Agreement is not intended to confer upon any non-party rights or remedies hereunder, except
as may be received or created as part of a valid assignment. 
 10.14 Further Assurances. Each of the Parties agrees to duly execute
and deliver, or cause to be duly executed and delivered, such further instruments and do and cause to be done such further acts and things, including the filing of such additional assignments, agreements, documents, and instruments, that may be
necessary or as the other Party hereto may at any time and from time to time reasonably request in connection with this Agreement or to 

  
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carry out more effectively the provisions and purposes of, or to better assure and confirm unto such other Party its rights and remedies under, this Agreement. 

10.15 Counterparts. This Agreement may be signed in counterparts, each and every one of which shall be deemed an original. Electronic
or Facsimile signatures shall be treated as original signatures. 
 10.16 [...***...] 

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 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first written above.

  

									
	PATHEON UK LIMITED:	 		 	FLEXION THERAPEUTICS, INC.:
					
	By:	 	 /s/ A.M. Botterill
	 		 	By:	 	 /s/ Michael D. Clayman, M.D.

					
	Name:	 	 A.M. Botterill
	 		 	Name:	 	 Michael D. Clayman, M.D.

					
	Title:	 	 Exec. Dir. & Gen. Manager
	 		 	Title:	 	 CEO

  

	
	[...***...]

  
  

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 Schedule 2.9 

[...***...] 

  
  

***Confidential Treatment Requested for pages 64-65. 

Omitted pages have been filed separately with the Commission. 

64-65 

 Schedule 1.60 

[...***...] 

  
  

***Confidential Treatment Requested for pages 66-71. 

Omitted pages have been filed separately with the Commission. 

66-71 

 Schedule 1.62 

[...***...] 

  
  

***Confidential Treatment Requested 

72 

 Schedule 1.82 

[...***...] 

  
  

***Confidential Treatment Requested 

73 

 Schedule 2.1(a) 
  

	I.	[...***...] 

  
  

***Confidential Treatment Requested for pages 74-80. 

Omitted pages have been filed separately with the Commission. 

74-80 

 Schedule 6.4(a) 

[...***...] 

  
  

***Confidential Treatment Requested for pages 81-83. 

Omitted pages have been filed separately with the Commission. 

81-83 

 Schedule 8.4(a) 

[...***...] 

  
  

***Confidential Treatment Requested for pages 84-85. 

Omitted pages have been filed separately with the Commission. 

84-85

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