Document:

Employment Agreement with Mark Leuchtenberger

 Exhibit 10.3 
 EMPLOYMENT AGREEMENT 
 THIS EMPLOYMENT AGREEMENT (the “Agreement”) is made as of this 12th day of September, 2006, by and between Targanta Therapeutics Corporation, (the “Company”), and Mark Leuchtenberger (“Employee”) (collectively, the
“Parties”). 
 WHEREAS, the Company wishes to employ Employee and to assure itself of
the continued services of Employee on the terms set forth herein; 
 WHEREAS, Employee wishes to be so employed under
the terms set forth herein; 
 NOW, THEREFORE, in consideration of the mutual promises
and covenants contained herein, it is hereby agreed by and between the Parties hereto as follows: 
 1. EMPLOYMENT. The
Company will employ Employee and Employee shall serve the Company in the capacity of President and Chief Executive Officer (“CEO”). The Employee’s employment with the Company shall commence on September 18, 2006.

 2. AT-WILL EMPLOYMENT. It is understood and agreed by the Parties that this Agreement
does not contain any promise or representation concerning the duration of Employee’s employment with the Company. Employee specifically acknowledges that his employment with the Company is at-will and may be altered or terminated by either
Employee or the Company at any time, with or without Cause (as defined below) and with or without notice. The nature, terms or conditions of Employee’s employment with the Company cannot be changed by any oral representation, custom, habit or
practice. In addition, that the rate of salary, any bonuses, paid time off, other compensation, or vesting schedules are stated in units of years or months or weeks does not alter the at-will nature of the employment, and does not mean and should
not be interpreted to mean that Employee is guaranteed employment to the end of any period of time or for any period of time. In the event of conflict between this disclaimer and any other statement, oral or written, present or future, concerning
terms and conditions of employment, the at-will relationship confirmed by this disclaimer shall control. This at-will status cannot be altered except in a writing signed by Employee and approved by the Board of Directors of the Company (the
“Board of Directors”) 
 3. DUTIES. Employee shall render exclusive, full-time services to the Company
as its President and CEO and, subject to election by the stockholders, shall also serve as a member of the Board of Directors of the Company and each of its two Canadian subsidiaries pursuant to Section 3 of the Unanimous Shareholders
Agreement, dated as of December 23, 2005, by and among the Company, its two Canadian subsidiaries and their respective shareholders (as such agreement may be amended or restated from time to time). Employee shall report to the Board of
Directors. Employee shall perform services under this Agreement primarily at the office of the Company to be located in the Commonwealth of Massachusetts, and from time to time at such other locations (including Indianapolis) as is necessary to
perform the duties of President and CEO under this Agreement. Subject to the terms of this Agreement, Employee’s responsibilities, working conditions and duties may be changed, added to, diminished or eliminated during his employment at the
sole discretion of the Board of Directors. During 

  

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Employee’s employment with the Company he shall devote his best efforts and his full business time, skill and attention to the performance of his duties
on behalf of the Company. Employee shall be permitted to (i) continue to engage in his existing charitable and civic activities with Beth Israel Deaconess Medical Center, the Massachusetts Biotech Council and Wake Forest University
(ii) continue to serve on the board of directors of Epix Pharmaceuticals, Inc., and (iii) engage in other charitable or civic activities, provided that such activities described in (i) through (iii) above do not unreasonably
interfere (as determined in the reasonable discretion of the Board of Directors) with the performance of his duties on behalf of the Company. 
 4. POLICIES AND PROCEDURES. Employee agrees that he is subject to and will comply with the policies and procedures of the Company as such policies and procedures may be modified, added to
or eliminated from time to time at the sole discretion of the Company, except to the extent any such policy or procedure specifically conflicts with the express terms of this Agreement. Employee further agrees and acknowledges that any written or
oral policies and procedures of the Company do not constitute contracts between the Company and Employee. 
 5. BASE
SALARY. For all services rendered and to be rendered hereunder, the Company agrees to pay to the Employee, and the Employee agrees to accept a salary of $350,000 per annum (“Base Salary”), which salary will be
paid periodically in accordance with normal Company payroll practices and shall be subject to such deductions and withholdings as the Company is required to make pursuant to law, or by further agreement with the Employee. Employee’s salary
shall be subject to annual review and discretionary adjustment by the Board of Directors. 
 6. STOCK
OPTIONS. 
 (a) Grant of Options. In connection with Employee’s commencement of employment by
the Company, the Company will grant Employee options to purchase 1,600,000 shares of the Company’s common stock, such options to be granted at the then-current fair market value of the common stock as determined by the Board of Directors (the
“Options”). The terms, conditions and limitations of the Options will be set forth in the Company’s 2005 Stock Option Plan (the “Plan”) and in the standard form of notice of stock option grant and stock option
agreement to be approved by the Board of Directors and to be entered into by Employee, such terms and conditions to include provisions providing that the Options shall vest quarterly over four years, commencing on September 18, 2006 (such that
the first 100,000 shares shall vest on December 18, 2006), subject to acceleration in certain circumstances as further described below. Employee shall be eligible to receive future grants of equity incentives as determined by the Board of
Directors (or the compensation committee thereof) in its sole discretion. 
 (b) Anti-Dilution Protection on Options.
The Parties acknowledge that the Company and its subsidiaries anticipate consummating a future financing transaction, which transaction shall be approved by the Board of Directors and result in aggregate proceeds to the Company and its subsidiaries
of at least $20,000,000 (the “Next Financing”). If Employee’s equity ownership in the Company on a fully diluted, as-if exercised basis (assuming full conversion of all convertible securities (including the 

  

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exchange of all exchangeable shares) and full exercise of all outstanding warrants and options and all options reserved for issuance under the Plan) (a
“Fully Diluted Basis”) following the Next Financing would be less than 3% of the total number of shares of the Company’s capital stock deemed to be outstanding on a Fully Diluted Basis, the Board of Directors agrees, in
connection with the closing of the Next Financing, under the Plan, to grant to Employee options to purchase such number of additional shares of the Company’s common stock as would be necessary to provide that Employee’s ownership of the
Company on a Fully Diluted Basis equals 3%. 
 7. BONUS. Employee may be eligible to receive an annual performance
bonus of up to 50% of his Base Salary (subject to employment taxes, withholding and deductions) for each year of this Agreement beginning January 1, 2007, based upon Employee’s achievements of certain milestones and performance objectives
to be mutually agreed upon by the Board of Directors and the Employee (the “Bonus”). Except as expressly provided otherwise herein, Employee must remain employed by the Company throughout the applicable bonus year in order to be
eligible for any Bonus. The Board of Directors, in its sole discretion, shall determine the extent to which Employee has achieved the performance targets upon which Employee’s Bonus is based, and the amount of Bonus to be paid to Employee, if
any. Bonuses are not earned until they are approved in writing by the Board of Directors. 
 8. OTHER
BENEFITS. While employed by the Company as provided herein: 
 (a) Employee Benefits. Employee shall
be entitled to all benefits to which other executive officers of the Company are entitled, on terms comparable thereto, including, without limitation, participation in pension and profit sharing plans, 401(k) plan, group insurance policies and
plans, medical, health, vision, and disability insurance policies and plans, and the like, which benefits may be maintained by the Company for the benefit of its executives. The Company reserves the right to alter and amend the benefits received by
Employee from time to time at the Company’s discretion. 
 (b) Expense Reimbursement. Employee shall receive,
against presentation of proper receipts and vouchers, reimbursement for direct and reasonable out-of-pocket expenses incurred by him in connection with the performance of his duties hereunder, according to the Company’s policies. 
 (c) Vacation. Employee will be entitled to thirty (30) vacation days per year, which will accrue in monthly increments.

 (d) Life Insurance. For so long as Employee remains employed by the Company and provided that the cost associated
herewith is reasonably acceptable to the Board of Directors (or the compensation committee thereof), the Company shall pay the annual premium on a life insurance policy, valued at $1,000,000, on Employee’s life, the beneficiary of which shall
be selected by Employee. 
  

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 9. CONFIDENTIAL INFORMATION, RIGHTS AND
DUTIES. 
 (a) Proprietary Information. Employee will, as a condition to commencing his employment
with the Company, execute and deliver to the Company an Agreement Re: Non-Competition, Non-Solicitation, Non-Disclosure and Ownership of Inventions in the form attached hereto as Exhibit A. 
 (b) Exclusive Property. Employee agrees that all Company-related business procured by the Employee, and all Company-related
business opportunities and plans made known to Employee while employed by the Company, are and shall remain the permanent and exclusive property of the Company. 
 (c) Non-Solicitation; Non-Competition. Employee agrees that following his last day of employment with the Company, he shall
continue to comply with the non-competition and non-solicitation obligations set forth in the Agreement Re: Non-Competition, Non-Solicitation, Non-Disclosure and Ownership of Inventions for the entire time period set forth therein. 
 10. TERMINATION. The Parties each acknowledge that either of the Parties has the right to terminate Employee’s employment with
the Company at any time for any reason whatsoever, with or without Cause or advance notice. 
 (a) Payments through
Termination. Upon termination of Employee’s employment for any reason, whether voluntary, involuntary, or due to death or Disability, the Company’s obligation to make payments shall terminate except the Company shall pay Employee (or
his estate) any amount of Base Salary and Bonus earned through the date of termination, any benefits vested through the date of termination, all unused vacation accrued through the date of termination, and any business expenses that were incurred
but not reimbursed as of the date of termination. Vesting of the Options and any other equity incentives granted to Employee after the date hereof shall cease on the date of termination. 
 (b) Severance Benefits. In the event that (A) Employee’s employment is terminated at any time without Cause or due to his
death or Disability, or Employee resigns for Good Reason within the twenty-four (24) month period following a Change of Control, and (B) upon the execution of a release in the form attached as Exhibit B (“Release”)
by Employee (or his estate) and written acknowledgment of Employee’s continuing obligations under the Agreement Re: Non-Competition, Non-Solicitation, Non-Disclosure and Ownership of Inventions, Employee (or his estate) shall be entitled to
receive the following additional pay and benefits: 
 (i) Severance Pay. The equivalent of twelve (12) months of
Employee’s Base Salary as in effect immediately prior to the date of his termination (the “Severance Pay”), payable on the same basis and at the same time as previously paid and subject to employment tax withholdings and
deductions, commencing on the first regularly scheduled pay date following the Effective Date of the Release; provided that the payment period shall be extended from twelve (12) months to eighteen (18) months if Employee’s
termination 

  

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occurs at a time when Employee has been employed by the Company for at least two (2) years (such twelve (12) or eighteen (18) month period to
be the “Severance Period”); 
 (ii) Pro Rated Bonus. Unless the Employee’s termination is due to
his death, the Employee shall be deemed to have earned (on a pro rated basis) as of the date of his termination that portion of any Bonus that the Board, in its discretion, otherwise would have awarded the Employee as of such date, based on his
achieving (on a pro rated basis) the performance targets upon which Employee’s Bonus is based. The payment of any such pro rated Bonus shall be made by the Company in accordance with its standard policies and procedures following the end of the
year in which the Bonus was earned; and 
 (iii) Medical and Dental Benefits. Provided that Employee or his dependents
are eligible for and timely elect continued coverage under the Company’s group health and/or dental insurance plans pursuant to the federal law known as “COBRA,” for the duration of the Severance Period the Company shall reimburse
Employee or his dependents for the cost of the COBRA premiums (less an amount equal to the employee portion of such premiums in accordance with the Company’s then standard employee policies regarding health and dental insurance premiums),
provided, however, that the Company’s obligation to pay the COBRA premiums in respect of health and/or dental insurance, as the case may be, will cease immediately in the event Employee or his dependents become
eligible for other group health or dental insurance during the Severance Period, and Employee or his dependents (as the case may be) shall promptly notify the Company if he/they become eligible to be covered by other group health or dental insurance
during the Severance Period. Except for any right Employee has to continue participation in the Company’s group health and dental plans under COBRA, all employee benefits shall terminate in accordance with the terms of the applicable benefit
plans as of the date of termination of the Employee’s employment by the Company (or one of its subsidiaries). 
 (iv)
Definition of Severance Benefits. The Severance Pay, pro-rated Bonus, and COBRA reimbursement described in Sections 10(b)(i)-(iii) above are collectively referred to as the “Severance Benefits.” 
 (c) Definition of Cause. For purposes of this Agreement, “Cause” means (i) Employee’s incompetence or
failure or refusal to perform satisfactorily any duties reasonably required of Employee by the Board of Directors and/or the Company (other than by reason of Disability), including Employee’s continuing inattention to or neglect of his duties
and responsibilities reasonably assigned to him by the Company and/or its Board of Directors; (ii) Employee’s violation of any law, rule or regulation (other than traffic violations, misdemeanors or similar offenses) or cease-and-desist
order, court order, judgment, regulatory directive or agreement or Employee’s conviction of or plea of nolo contendere to a felony or a crime involving moral turpitude; (iii) the commission or omission of or engaging in any act or
practice that constitutes a material breach of 

  

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Employee’s fiduciary duty to the Company, involves personal dishonesty, fraud or misrepresentation on the part of Employee or demonstrates a willful or
continuing disregard for the best interests of the Company; (iv) Employee’s engaging in dishonorable or disruptive behavior, practices or acts that would be reasonably expected to harm or bring disrepute to the Company, its subsidiaries,
its business or any of its customers, employees or vendors; or (v) a breach by Employee of his obligations under the Agreement Re: Non-Competition, Non-Solicitation, Non-Disclosure and Ownership of Inventions or any Company code of conduct or
ethics or other Company policies or practices. 
 (d) Definition of Good Reason. For purposes of this Agreement,
“Good Reason” means (i) the failure of the Company to employ Employee in his current or a substantially similar position, without regard to title, such that his duties and responsibilities are materially diminished without his
consent (provided that he notifies the Company in writing of such diminution of duties within 60 days of the diminution); (ii) a reduction in Employee’s Base Salary and/or target annual Bonus without his consent (unless such
reduction is in connection with a proportional reduction in compensation to all or substantially all of the Company’s employees); or (iii) a permanent relocation of Employee’s primary place of employment more than 50 miles from his
current site of employment without Employee’s consent. 
 (e) Definition of Disability. For purposes of this
Agreement, “Disability” means the Employee’s inability to carry out his job responsibilities for a continuous period of more than six (6) months as a result of illness (mental or physical), accident, or injury, as
reasonably determined in the sole discretion of the Board of Directors. 
 11. CHANGE IN
CONTROL BENEFITS. 
 (a) Definition of Change of Control. A “Change of
Control” shall mean any of the following events, if and only if such event or events occurs after the Next Financing: (i) the dissolution or liquidation of the Company, (ii) any merger or consolidation of the Company with one
(1) or more corporations where the Company is the surviving corporation and the stockholders of the Company (including any holder of exchangeable shares of the Canadian subsidiaries) immediately prior to such transaction do not own at least
fifty percent (50%) of the Company’s outstanding capital stock (assuming the exchange of all outstanding exchangeable shares of the Canadian subsidiaries) immediately after such transaction, (iii) any merger or consolidation of the
Company with one or more corporations where the Company is not the surviving corporation, or (iv) a sale of substantially all of the assets of the Company or fifty percent (50%) or more of the then outstanding shares of capital stock of
the Company (assuming the exchange of all exchangeable shares of the Canadian subsidiaries) to another corporation or entity. 
 (b) Acceleration of Options upon a Change in Control. In the event that (i) Employee’s employment is terminated without Cause at any time following a Change in Control or (ii) Employee resigns for Good Reason at any
time following a Change of 

  

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Control, then all Options issued to Employee in connection with this Agreement and any other options or shares of restricted stock then held by Employee that
have not yet vested shall immediately vest such that all of the remaining unvested shares under the Options and any other equity incentive granted to Employee during the course of his employment by the Company shall, at the time of the termination
without Cause or resignation for Good Reason, immediately become vested shares. All other terms and conditions set forth in the Options, the Plan, and applicable notices of stock option grant, stock option agreements and restricted stock agreements,
if applicable, shall remain in full force and effect. 
 (c) Section 4999 Compliance. If the Company reasonably
determines after consultation with its counsel that any benefit accorded to the Employee under this Section 11 or any other provision or agreement between the Company and the Employee (“Other Agreement”) would cause the
imposition of an excise tax upon the Employee under Section 4999 of the Internal Revenue Code of 1986, as amended (the “Code”), then the Company shall adjust the timing and/or the amount of any payment or benefit to the
Employee pursuant to this Section 11 or Other Agreement so that the excise tax imposed by Section 4999 shall not be imposed upon any such payment or benefit due to the Employee. The Company shall consult with the Employee regarding such
adjustments, but shall retain the power to control the timing and amounts of any such adjustments. 
 12. CODE
SECTION 409A COMPLIANCE. Because of the uncertainty of the application of Section 409A of the Internal Revenue Code of 1986, as amended (the “Code”) to payments pursuant to this Agreement,
including, without limitation, payments pursuant to Sections 10 and 11 hereof, Employee agrees that if any such payments are subject to the provisions of Section 409A(a)(1) of the Code by reason of this Agreement, or any part thereof, being
considered a “nonqualified deferred compensation plan” pursuant to Section 409A of the Code, then such payments shall be made in accordance with, and this Agreement automatically shall be amended in such a manner as to prevent any
current or future payment to the Employee under this Agreement or the vesting of any Company stock option or other equity incentive held issued to the Employee becoming subject to Section 409A(a)(1) of the Code, including, without limitation,
any necessary delay of six (6) months applicable to payment of deferred compensation to a “specified employee” (as defined in Section 409A(2)(B)(i) of the Code) upon separation from service. In the event that a six month delay is
required, on the first regularly scheduled pay date following the conclusion of the delay period the Employee shall receive a lump sum payment in an amount equal to six (6) months of Employee’s Base Salary and thereafter, any remaining
Severance Benefits shall be paid on the same basis and at the same time as previously paid and subject to employment tax withholdings and deductions. The Company and the Employee shall consult together in good faith to determine the manner in which
this Agreement should be amended to avoid the application of Section 409A(a)(1) as provided herein while avoiding or minimizing any financial disadvantage to the Employee as might arise from such amendment, but in case of disagreement the
decision of the Board of Directors shall govern, and the Company and the Employee shall be bound thereby. 
  

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 13. MISCELLANEOUS. 
 (a) Taxes; Withholding. Employee agrees to be responsible for the payment of any taxes due on any and all compensation, stock
options, equity incentives and other benefits provided by the Company pursuant to this Agreement and hereby acknowledges that all payments made by the Company to Employee under this Agreement shall be reduced by any tax or other amounts required to
be withheld by the Company under applicable law. Employee agrees to indemnify the Company and hold the Company harmless from any and all claims or penalties asserted against the Company for any failure to pay taxes due on any compensation, stock
option, or benefit provided by the Company pursuant to this Agreement. Employee expressly acknowledges that the Company has not made, nor herein makes, any representation about the tax consequences of any consideration provided by the Company to
Employee pursuant to this Agreement. 
 (b) Modification/Waiver. This Agreement may not be amended, modified,
superseded, canceled, renewed or expanded, or any terms or covenants hereof waived, except by a writing executed by each of the parties hereto or, in the case of a waiver, by the party waiving compliance. Failure of any party at any time or times to
require performance of any provision hereof shall in no manner affect his or its right at a later time to enforce the same. No waiver by a party of a breach of any term or covenant contained in this Agreement, whether by conduct or otherwise, in any
one or more instances shall be deemed to be or construed as a further or continuing waiver of that or any other term or covenant in this Agreement. 
 (c) Successors and Assigns. This Agreement shall be binding upon and shall inure to the benefit of any successors or assignees of the business of the Company. This Agreement shall not be assignable by the
Employee. 
 (d) Notices. All notices given hereunder shall be given by certified mail, addressed, or delivered by
hand, to the other party at his or its address as set forth herein, or at any other address hereafter furnished by notice given in like manner. Employee promptly shall notify Company of any change in Employee’s address. Each notice shall be
dated the date of its mailing or delivery and shall be deemed given, delivered or completed on such date. 
 (e) Governing
Law; Personal Jurisdiction and Venue. This Agreement and all disputes relating to this Agreement shall be governed in all respects by the laws of the Commonwealth of Massachusetts without regard to its conflicts of laws principles, and all
disputes hereunder shall be adjudicated in the courts of the Commonwealth of Massachusetts, to whose personal jurisdiction the Parties hereby consent. 
 (f) Entire Agreement. This Agreement, together with the Exhibits A and B attached hereto, sets forth the entire agreement and understanding of the parties hereto with regard to the employment of
the Employee by the Company and supersedes any and all prior agreements, arrangements and understandings, written or oral, pertaining to the subject matter hereof. No representation, promise or inducement relating to the subject matter hereof has
been made to a party that is not embodied in these Agreements, and 

  

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neither of the Parties shall be bound by or liable for any alleged representation, promise or inducement not so set forth. In consideration of the benefits
provided to Employee hereunder, Employee hereby agrees that, in the event of his termination from the Company, such benefits shall be in complete satisfaction of any and all obligations that the Company may have to Employee.
 (g) Severability. If any portion or provision of this Agreement shall to any extent be declared illegal or unenforceable by a
court of competent jurisdiction, then the remainder of this Agreement, or the application of such portion or provision in circumstances other than those as to which it is so declared illegal or unenforceable, shall not be affected thereby, and each
portion and provision hereof shall be valid and enforceable to the fullest extent permitted by law. 
 (h) Employer.
Employee shall be employed initially by the Company. During the term of this Agreement, Employee may be transferred to the employment of either or both of the Company’s Canadian subsidiaries, in which event the term “Company”
as used herein in reference to the employer of Employee shall refer to said subsidiary(ies). Any such transfer to the employment of a subsidiary, and/or any such transfer back to the employment of Company, shall not otherwise alter or affect the
terms or conditions of this Agreement, which shall continue to govern Employee’s employment relationship. 
 (i)
Counterparts. This Agreement may be executed in two counterparts, each of which shall be an original and all of which together shall constitute one and the same instrument. 
 (j) Fees. Each party shall be responsible for its own fees and expenses incurred in connection with negotiating this
Agreement, provided that the Company shall reimburse the Employee for up to [$2500] for his legal expenses incurred herewith. 
 [Remainder of Page Intentionally Left Blank.] 
  

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 IN WITNESS WHEREOF, the Parties have each duly
executed this Agreement as of the day and year first above written. 
  

			
	TARGANTA THERAPEUTICS CORPORATION
		
	By:	 	/s/ Alexander W. Moot
	Name:	 	Alexander W. Moot
	Title:	 	Chairman
	
	/s/ Mark Leuchtenberger
	MARK LEUCHTENBERGER

  

 10Employee Agreement with George Eldridge

 Exhibit 10.4 
 EMPLOYMENT AGREEMENT 
 THIS EMPLOYMENT AGREEMENT (the “Agreement”) is made as of this 25th day of September, 2006, by and between Targanta Therapeutics Corporation, (the “Company”), and George Eldridge (“Employee”) (collectively, the
“Parties”). 
 WHEREAS, the Company wishes to employ Employee and to assure itself of
the continued services of Employee on the terms set forth herein; 
 WHEREAS, Employee wishes to be so employed under
the terms set forth herein; 
 NOW, THEREFORE, in consideration of the mutual promises
and covenants contained herein, it is hereby agreed by and between the Parties hereto as follows: 
 1. EMPLOYMENT. The
Company will employ Employee and Employee shall serve the Company in the capacity of Treasurer and Chief Financial Officer (“CFO”). The Employee’s employment with the Company shall commence on September 25, 2006.

 2. AT-WILL Employment. It is understood and agreed by the Parties that this Agreement does not
contain any promise or representation concerning the duration of Employee’s employment with the Company. Employee specifically acknowledges that his employment with the Company is at-will and except as otherwise prohibited by law, may be
altered or terminated by either Employee or the Company at any time, with or without Cause (as defined below) and with or without notice. The nature, terms or conditions of Employee’s employment with the Company cannot be changed by any oral
representation, custom, habit or practice. In addition, that the rate of salary, any bonuses, paid time off, other compensation, or vesting schedules are stated in units of years or months or weeks does not alter the at-will nature of the
employment, and does not mean and should not be interpreted to mean that Employee is guaranteed employment to the end of any period of time or for any period of time. In the event of conflict between this disclaimer and any other statement, oral or
written, present or future, concerning terms and conditions of employment, the at-will relationship confirmed by this disclaimer shall control. This at-will status cannot be altered except in a writing signed by Employee and approved by the Board of
Directors of the Company (the “Board of Directors”). 
 3. DUTIES. Employee shall render
exclusive, full-time services to the Company as its CFO. Employee shall report to the Company’s Chief Executive Officer. Employee shall perform services under this Agreement primarily at the office of the Company to be located in the
Commonwealth of Massachusetts (the “Primary Location”), and from time to time at such other locations (including Indianapolis) as is necessary to perform the duties of CFO under this Agreement. Subject to the terms of this
Agreement, Employee’s responsibilities, working conditions and duties may be changed, added to, diminished or eliminated during his employment at the sole discretion of the Board of Directors. During Employee’s employment with the Company
he shall devote his reasonable best efforts and his full business time, skill and attention to the performance of his duties on behalf of the Company. 
  

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 4. POLICIES AND PROCEDURES. Employee agrees
that he is subject to and will comply with the policies and procedures of the Company as such policies and procedures may be modified, added to or eliminated from time to time at the sole discretion of the Company, except to the extent any such
policy or procedure specifically conflicts with the express terms of this Agreement. Employee further agrees and acknowledges that any written or oral policies and procedures of the Company do not constitute contracts between the Company and
Employee. 
 5. BASE SALARY. For all services rendered and to be rendered hereunder, the Company
agrees to pay to the Employee, and the Employee agrees to accept a salary of $220,000 per annum (“Base Salary”), which salary will be paid periodically in accordance with normal Company payroll practices and shall be subject to such
deductions and withholdings as the Company is required to make pursuant to law, or by further agreement with the Employee. Employee’s salary shall be subject to annual review and discretionary adjustment by the Board of Directors, which
discretion shall be exercised reasonably; provided that, upon the consummation of a future financing transaction or series of related transactions (including a so-called reverse merger of the Company with an existing public company), which
such transaction or transactions shall be approved by the Board of Directors and result in aggregate proceeds to the Company and its subsidiaries of at least $20,000,000 from persons who are not presently stockholders of the Company (including any
holder of exchangeable shares of the Canadian subsidiaries) (a “Next Financing”), the Employee’s Base Salary shall automatically be increased to $250,000 per annum and, upon the consummation of an initial public offering of the
Company’s common stock (which for this purpose should include a so-called reverse merger of the Company with an existing public company), the Employee’s Base Salary shall automatically be increased to $275,000 per annum. 
 6. STOCK OPTIONS. In connection with Employee’s commencement of employment by the
Company, and no later than the next regularly-scheduled meeting of the Board of Directors, the Company will grant Employee options to purchase 475,000 shares of the Company’s common stock, such options to be granted at the then-current fair
market value of the common stock as determined by the Board of Directors (the “Options”). The terms, conditions and limitations of the Options will be set forth in the Company’s 2005 Stock Option Plan (the “Plan”) and in the
standard form of notice of stock option grant and stock option agreement to be approved by the Board of Directors and to be entered into by Employee, such terms and conditions to include provisions providing that the Options shall vest quarterly
over four years, commencing on September 25, 2006 (such that the first 29,687 shares shall vest on December 25, 2006), subject to acceleration in certain circumstances as further described below. Employee shall be eligible to receive
future grants of equity incentives as determined by the Board of Directors (or the compensation committee thereof) in its sole discretion. 
 7. BONUS. Employee may be eligible to receive an annual performance bonus of up to 25% of his Base Salary (subject to employment taxes, withholding and deductions) for each year of this Agreement beginning
January 1, 2007, based upon Employee’s achievements of certain milestones and performance objectives to be mutually agreed upon by the Board of Directors and the Employee (the “Bonus”). Except as expressly provided
otherwise herein, Employee must remain employed by the Company throughout the applicable bonus year in order to be eligible for any Bonus. The Board of Directors, in its sole discretion, which shall be 

  

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exercised reasonably, shall determine the extent to which Employee has achieved the performance targets upon which Employee’s Bonus is based, and the
amount of Bonus to be paid to Employee, if any. Bonuses are not earned until they are approved in writing by the Board of Directors. 
 8. OTHER BENEFITS. While employed by the Company as provided herein: 
 (a) Employee Benefits. Employee shall be entitled to all benefits to which other executive officers of the Company are entitled, on terms comparable thereto, including, without limitation, participation in pension and profit
sharing plans, 401(k) plan, group insurance policies and plans, medical, health, vision, and disability insurance policies and plans, and the like, which benefits may be maintained by the Company for the benefit of its executives. The Company
reserves the right to alter and amend the benefits received by Employee from time to time at the Company’s discretion. 
 (b) Expense Reimbursement. Employee shall receive, against presentation of proper receipts and vouchers, reimbursement for direct and reasonable out-of-pocket expenses incurred by him in connection with the performance of his
duties hereunder, according to the Company’s policies. 
 (c) Vacation. Employee will be entitled to twenty
(20) vacation days per year, which will accrue in monthly increments. 
 9. CONFIDENTIAL
INFORMATION, RIGHTS AND DUTIES.  
 (a) Proprietary
Information. Employee will, as a condition to commencing his employment with the Company, execute and deliver to the Company an Agreement Re: Non-Competition, Non-Solicitation, Non-Disclosure and Ownership of Inventions in the form attached
hereto as Exhibit A. 
 (b) Exclusive Property. Employee agrees that all Company-related business
procured by the Employee, and all Company-related business opportunities and plans made known to Employee while employed by the Company, are and shall remain the permanent and exclusive property of the Company. 
 (c) Non-Solicitation; Non-Competition. Employee agrees that following his last day of employment with the Company, he shall
continue to comply with the non-competition and non-solicitation obligations set forth in the Agreement Re: Non-Competition, Non-Solicitation, Non-Disclosure and Ownership of Inventions for the entire time period set forth therein. 
  

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 10. TERMINATION. The Parties each acknowledge that either of the Parties has
the right to terminate Employee’s employment with the Company at any time for any reason whatsoever, with or without Cause or advance notice. 
 (a) Payments through Termination. Except as provided herein, upon termination of Employee’s employment for any reason, whether voluntary or involuntary, or due to death or Disability, the
Company’s obligation to make payments shall terminate except the Company shall pay Employee (or his estate) any amount of Base Salary and Bonus earned through the date of termination, any benefits vested through the date of termination, all
unused vacation accrued through the date of termination, and any business expenses that were incurred but not reimbursed as of the date of termination. Except as provided herein, vesting of the Options and any other equity incentives granted to
Employee after the date hereof shall cease on the date of termination. 
 (b) Severance Benefits Prior to a Change
of Control. In the event that Employee’s employment is terminated either without Cause or due to his death or Disability prior to a Change of Control, Employee shall be entitled to receive the following severance pay and benefits in
addition to the payments described in Section 10(a): 
 (i) Severance Pay. The equivalent of six
(6) months (the “Severance Pay Period”) of Employee’s Base Salary as in effect immediately prior to the date of his termination, payable on the same basis and at the same time as previously paid and subject to employment
tax withholdings and deductions, commencing on the first regularly scheduled pay date following the Effective Date of the Release; 
 (ii) Pro Rated Bonus. Unless the Employee’s termination is due to his death, the Employee shall be deemed to have earned (on a pro rated basis) as of the date of his termination that portion of any Bonus that the Board of
Directors, in its discretion, otherwise would have awarded the Employee as of such date, based on his achieving (on a pro rated basis) the performance targets upon which Employee’s Bonus is based. The payment of any such pro rated Bonus shall
be made by the Company in accordance with its standard policies and procedures following the end of the year in which the Bonus was earned; and 
 (iii) Medical and Dental Benefits. Provided that Employee or his dependents are eligible for and timely elect continued coverage under the Company’s group health and/or dental insurance plans
pursuant to the federal law known as “COBRA,” for the duration of the Severance Pay Period the Company shall reimburse Employee or his dependents for the cost of the COBRA premiums (less an amount equal to the employee portion of such
premiums in accordance with the Company’s then standard employee policies regarding health and dental insurance premiums), provided, however, that the Company’s obligation to pay the COBRA premiums in respect of
health and/or dental insurance, as the case may be, will cease immediately in the event Employee or his dependents (as the case may be) become eligible for other group health or dental insurance that is reasonably comparable in terms of the scope
and cost of coverage during the Severance Pay Period, and Employee or his dependents shall promptly notify the Company if he/they become eligible to be covered by other group health or dental 

  

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insurance during the Severance Pay Period. Except for any right Employee has to continue participation in the Company’s group health and dental plans
under COBRA, all employee benefits shall terminate in accordance with the terms of the applicable benefit plans as of the date of termination of the Employee’s employment by the Company (or one of its subsidiaries). 
 (iv) Definition of Severance Benefits. The severance pay, pro rated Bonus and COBRA reimbursement described in Sections
10(b)(i) through (iii) above are collectively referred to as the “Severance Benefits.” 
 (c)
Severance Benefits Following a Change of Control. In the event that, within twenty four (24) months following a Change of Control, Employee’s employment is terminated without Cause or as a result of death or Disability, or Employee
resigns for Good Reason, then, in addition to the payments described in Section 10(a), Employee shall be entitled to receive the Severance Benefits; provided, that the Severance Pay Period shall be twelve (12) months instead of six
(6) months. 
 (d) Conditions for Receipt of Severance Benefits. The Company’s obligation to pay
Severance Benefits shall be contingent upon the Executive signing a release in the form attached as Exhibit B (“Release”) and a written acknowledgment of Employee’s continuing obligations under the Agreement Re:
Non-Competition, Non-Solicitation, Non-Disclosure and Ownership of Inventions. 
 (e) Definition of Cause. For
purposes of this Agreement, “Cause” means (i) Employee’s incompetence or failure or refusal to perform satisfactorily any duties reasonably required of Employee by the Board of Directors and/or the Company (other than by
reason of Disability), including Employee’s continuing inattention to or neglect of his duties and responsibilities reasonably assigned to him by the Company and/or its Board of Directors, which failure or inaction is not cured by Employee
within 30 days of receiving written notice of such event or events giving rise to a claim of Cause; (ii) Employee’s violation of any law, rule or regulation (other than traffic violations, misdemeanors or similar offenses) or
cease-and-desist order, court order, judgment, regulatory directive or agreement or Employee’s conviction of or plea of nolo contendere to any felony or a crime involving moral turpitude; (iii) the commission or omission of or
engaging in any act or practice that constitutes a material breach of Employee’s fiduciary duty to the Company, involves personal dishonesty, fraud or misrepresentation on the part of Employee or demonstrates a willful or continuing disregard
for the best interests of the Company; (iv) Employee’s engaging in dishonorable or disruptive behavior, practices or acts that would be reasonably expected to harm or bring disrepute to the Company, its subsidiaries, its business or any of
its customers, employees or vendors; or (v) a breach by Employee of his obligations under the Agreement Re: Non-Competition, Non-Solicitation, Non-Disclosure and Ownership of Inventions or any Company code of conduct or ethics or other Company
policies or practices. In any case where the Company believes that the Employee may be terminated for Cause, it shall provide Employee with a written notice setting forth, in reasonable detail, the factual basis for such claimed Cause prior to or at
the time of such termination. 
  

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 (f) Definition of Good Reason. For purposes of this Agreement,
“Good Reason” means (i) the failure of the Company to employ Employee in his current or a substantially similar position with the same reporting relationship, without regard to title, such that his duties and responsibilities
are materially diminished without his written consent (provided that he notifies the Company in writing of such diminution of duties within 45 days of the diminution); (ii) a reduction in Employee’s Base Salary and/or target annual
Bonus without his written consent (unless such reduction is in connection with a proportional reduction in compensation to all or substantially all of the Company’s employees); or (iii) a permanent relocation of Employee’s Primary
Location more than 50 miles from his current site of employment without Employee’s written consent. 
 (g)
Definition of Disability. For purposes of this Agreement, “Disability” means the Employee’s inability to carry out his job responsibilities for a continuous period of more than six (6) months as a result of illness
(mental or physical), accident, or injury, as reasonably determined in the sole discretion of the Board of Directors. 
 11.
CHANGE IN CONTROL BENEFITS. 
 (a) Definition of
Change of Control. A “Change of Control” shall mean any of the following events, if and only if such event or events occurs after the Next Financing: (i) the dissolution or liquidation of the Company, (ii) any merger
or consolidation of the Company with one (1) or more corporations where the Company is the surviving corporation and the stockholders of the Company (including any holder of exchangeable shares of the Canadian subsidiaries) immediately prior to
such transaction do not own at least fifty percent (50%) of the Company’s outstanding capital stock (assuming the exchange of all outstanding exchangeable shares of the Canadian subsidiaries) immediately after such transaction,
(iii) any merger or consolidation of the Company with one or more corporations where the Company is not the surviving corporation, or (iv) a sale of substantially all of the assets of the Company or fifty percent (50%) or more of the
then outstanding shares of capital stock of the Company (assuming the exchange of all exchangeable shares of the Canadian subsidiaries) to another corporation or entity. 
 (b) Acceleration of Options upon a Change in Control. In the event that (i) Employee’s employment is terminated without
Cause at any time following a Change in Control or within thirty (30) days prior to the consummation of a Change of Control or (ii) Employee resigns for Good Reason at any time following a Change of Control, then all Options issued to
Employee in connection with this Agreement and any other options or shares of restricted stock then held by Employee that have not yet vested shall immediately vest such that all of the remaining unvested shares under the Options and any other
equity incentive granted to Employee during the course of his employment by the Company shall, at the time of the termination without Cause or resignation for Good Reason, immediately become vested shares. All other terms and conditions set forth in
the Options, the Plan, and applicable notices of stock option grant, stock option agreements and restricted stock agreements, if applicable, shall remain in full force and effect. 
  

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 (c) Section 4999 Compliance. If the Company reasonably determines
after consultation with its counsel that any benefit accorded to the Employee under this Section 11 or any other provision or agreement between the Company and the Employee (“Other Agreement”) would cause the imposition of an
excise tax upon the Employee under Section 4999 of the Internal Revenue Code of 1986, as amended (the “Code”), then the Company shall adjust the timing and/or the amount of any payment or benefit to the Employee pursuant to
this Section 11 or Other Agreement so that the excise tax imposed by Section 4999 shall not be imposed upon any such payment or benefit due to the Employee. The Company shall consult with the Employee regarding such adjustments, but shall
retain the power to control the timing and amounts of any such adjustments. 
 12. CODE
SECTION 409A COMPLIANCE. Because of the uncertainty of the application of Section 409A of the Internal Revenue Code of 1986, as amended (the “Code”) to payments pursuant to this Agreement,
including, without limitation, payments pursuant to Sections 10 and 11 hereof, Employee agrees that if any such payments are subject to the provisions of Section 409A(a)(1) of the Code by reason of this Agreement, or any part thereof, being
considered a “nonqualified deferred compensation plan” pursuant to Section 409A of the Code, then such payments shall be made in accordance with, and this Agreement automatically shall be amended in such a manner as to prevent any
current or future payment to the Employee under this Agreement or the vesting of any Company stock option or other equity incentive held issued to the Employee becoming subject to Section 409A(a)(1) of the Code, including, without limitation,
any necessary delay of six (6) months applicable to payment of deferred compensation to a “specified employee” (as defined in Section 409A(2)(B)(i) of the Code) upon separation from service. In the event that a six month delay is
required, on the first regularly scheduled pay date following the conclusion of the delay period the Employee shall receive a lump sum payment in an amount equal to six (6) months of Employee’s Base Salary and thereafter, any remaining
Severance Benefits shall be paid on the same basis and at the same time as previously paid and subject to employment tax withholdings and deductions. The Company and the Employee shall consult together in good faith to determine the manner in which
this Agreement should be amended to avoid the application of Section 409A(a)(1) as provided herein while avoiding or minimizing any financial disadvantage to the Employee as might arise from such amendment, but in case of disagreement the
decision of the Board of Directors shall govern, and the Company and the Employee shall be bound thereby. 
 13.
MISCELLANEOUS. 
 (a) Taxes; Withholding. Employee agrees to be responsible for the
payment of any taxes due on any and all compensation, stock options, equity incentives and other benefits provided by the Company pursuant to this Agreement and hereby acknowledges that all payments made by the Company to Employee under this
Agreement shall be reduced by any tax or other amounts required to be withheld by the Company under applicable law. Employee agrees to indemnify the Company and hold the Company harmless from any and all claims or penalties asserted against the
Company for any 

  

 7 

 
failure to pay taxes due on any compensation, stock option, or benefit provided by the Company pursuant to this Agreement. Employee expressly acknowledges
that the Company has not made, nor herein makes, any representation about the tax consequences of any consideration provided by the Company to Employee pursuant to this Agreement. 
 (b) Modification/Waiver. This Agreement may not be amended, modified, superseded, canceled, renewed or expanded, or any
terms or covenants hereof waived, except by a writing executed by each of the parties hereto or, in the case of a waiver, by the party waiving compliance. Failure of any party at any time or times to require performance of any provision hereof shall
in no manner affect his or its right at a later time to enforce the same. No waiver by a party of a breach of any term or covenant contained in this Agreement, whether by conduct or otherwise, in any one or more instances shall be deemed to be or
construed as a further or continuing waiver of that or any other term or covenant in this Agreement. 
 (c)
Successors and Assigns. This Agreement shall be binding upon and shall inure to the benefit of any successors or assignees of the business of the Company. This Agreement shall not be assignable by the Employee. 
 (d) Notices. All notices given hereunder shall be given by certified mail, addressed, or delivered by hand, to the other
party at his or its address as set forth herein, or at any other address hereafter furnished by notice given in like manner. Employee promptly shall notify Company of any change in Employee’s address. Each notice shall be dated the date of its
mailing or delivery and shall be deemed given, delivered or completed on such date. 
 (e) Governing Law; Personal
Jurisdiction and Venue. This Agreement and all disputes relating to this Agreement shall be governed in all respects by the laws of the Commonwealth of Massachusetts without regard to its conflicts of laws principles, and all disputes hereunder
shall be adjudicated in the courts of the Commonwealth of Massachusetts, to whose personal jurisdiction the Parties hereby consent. 
 (f) Entire Agreement. This Agreement, together with the Exhibits A and B attached hereto, sets forth the entire agreement and understanding of the parties hereto with regard to the employment of the Employee by
the Company and supersedes any and all prior agreements, arrangements and understandings, written or oral, pertaining to the subject matter hereof. No representation, promise or inducement relating to the subject matter hereof has been made to a
party that is not embodied in these Agreements, and neither of the Parties shall be bound by or liable for any alleged representation, promise or inducement not so set forth. In consideration of the benefits provided to Employee hereunder, Employee
hereby agrees that, in the event of his termination from the Company, such benefits shall be in complete satisfaction of any and all obligations that the Company may have to Employee.
 (g) Severability. If any portion or provision of this Agreement shall to any extent be declared illegal or
unenforceable by a court of competent jurisdiction, then the 

  

 8 

 
remainder of this Agreement, or the application of such portion or provision in circumstances other than those as to which it is so declared illegal or
unenforceable, shall not be affected thereby, and each portion and provision hereof shall be valid and enforceable to the fullest extent permitted by law. 
 (h) Employer. Employee shall be employed initially by the Company. During the term of this Agreement, Employee may be transferred to the employment of either or both of the Company’s Canadian
subsidiaries, in which event the term “Company” as used herein in reference to the employer of Employee shall refer to said subsidiary(ies). Any such transfer to the employment of a subsidiary, and/or any such transfer back to the
employment of Company, shall not otherwise alter or affect the terms or conditions of this Agreement, which shall continue to govern Employee’s employment relationship. 
 (i) Counterparts. This Agreement may be executed in two counterparts, each of which shall be an original and all of which
together shall constitute one and the same instrument. 
 (j) Fees. Each party shall be responsible for its
own fees and expenses incurred in connection with negotiating this Agreement, provided that the Company shall reimburse the Employee for up to $2,500 for his legal expenses incurred herewith. 
 [Remainder of Page Intentionally Left Blank.] 
  

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 IN WITNESS WHEREOF, the Parties have each duly
executed this Agreement as of the day and year first above written. 
  

			
	TARGANTA THERAPEUTICS CORPORATION
		
	By:	 	/s/ Mark Leuchtenberger
	Name:	 	Mark Leuchtenberger
	Title:	 	President and CEO

  

	
	
	
	/s/ George Eldridge
	GEORGE ELDRIDGE

  

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