Document:

exv4w2

 

Exhibit 4.2

EXECUTION COPY

REGISTRATION RIGHTS AGREEMENT

by and among

HUMAN GENOME SCIENCES, INC.

and

THE INITIAL PURCHASERS NAMED HEREIN

Dated August 9, 2005

     Registration Rights Agreement (this “Agreement”), dated as of August 9, 2005, by and
among Human Genome Sciences, Inc., a Delaware corporation (together with any successor entity, the
“Issuer”) and Citigroup Global Markets Inc. (“Citigroup”) and Merrill Lynch,
Pierce, Fenner & Smith Incorporated (“Merrill Lynch”) (each, an “Initial Purchaser”
and, collectively, the “Initial Purchasers”).

     Pursuant to the Purchase Agreement, dated August 4, 2005, by and among the Issuer and the
Initial Purchasers (the “Purchase Agreement”), the Initial Purchasers have agreed to
purchase from the Issuer up to $230,000,000 in aggregate principal amount of 21/4% Convertible
Subordinated Notes Due 2012 (the “Notes”). The Notes will be convertible into fully paid,
nonassessable shares of common stock, par value $0.01 per share, of the Issuer (the “Common
Stock”) on the terms, and subject to the conditions, set forth in the Indenture (as defined
herein). To induce the Initial Purchasers to purchase the Notes, the Issuer has agreed to provide
the registration rights set forth in this Agreement pursuant to the Purchase Agreement.

     The parties hereby agree as follows:

     SECTION 1. Definitions. As used in this Agreement, the following capitalized terms
shall have the following meanings:

     Advice: As defined in Section 4(c)(ii) hereof.

     Agreement: As defined in the preamble hereto.

     Business Day: A day other than a Saturday or Sunday or any federal holiday in the
United States.

     Citigroup: As defined in the preamble hereto.

 

 

     Commission: Securities and Exchange Commission.

     Common Stock: As defined in the preamble hereto.

     Damages Payment Date: Each Interest Payment Date.

     Effectiveness Period: As defined in Section 2(a)(iii) hereof.

     Effectiveness Target Date: As defined in Section 2(a)(ii) hereof.

     Exchange Act: Securities Exchange Act of 1934, as amended.

     Holder: A Person who owns, beneficially or otherwise, Transfer Restricted Securities.

     Indenture: The Indenture, dated as of August 9, 2005, between the Issuer and The Bank
of New York, as trustee, pursuant to which the Notes are to be issued, as such Indenture is
amended, modified or supplemented from time to time in accordance with the terms thereof.

     Initial Purchasers: As defined in the preamble hereto.

     Interest Payment Date: As defined in the Indenture.

     Issuer: As defined in the preamble hereto.

     Liquidated Damages: As defined in Section 3(a) hereof.

     Majority of Holders: Holders holding over 50% of the aggregate principal amount of
Notes outstanding; provided, however, that, for purpose of this definition, a
holder of shares of Common Stock which constitute Transfer Restricted Securities and were issued
upon conversion of the Notes shall be deemed to hold an aggregate principal amount of Notes (in
addition to the aggregate principal amount of Notes held by such holder) equal to the aggregate
principal amount of Notes converted by such Holder into such shares of Common Stock.

     Merrill Lynch: As defined in the preamble hereto.

     NASD: National Association of Securities Dealers, Inc.

     Notes: As defined in the preamble hereto.

     Offering Memorandum: The offering memorandum of the Issuer relating to the Notes.

     Person: An individual, partnership, corporation, unincorporated organization, trust,
joint venture or a government or agency or political subdivision thereof.

     Prospectus: The prospectus included in a Shelf Registration Statement, as amended or
supplemented by any prospectus supplement and by all other amendments thereto, including
post-effective amendments, and all material incorporated by reference into such Prospectus.

     Purchase Agreement: As defined in the preamble hereto.

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     Questionnaire Deadline: As defined in Section 2(b) hereof.

     Record Holder: With respect to any Damages Payment Date, each Person who is a Holder
of Notes on the record date with respect to the Interest Payment Date on which such Damages Payment
Date shall occur.

     Registration Default: As defined in Section 3(a) hereof.

     Securities Act: Securities Act of 1933, as amended.

     Shelf Filing Deadline: As defined in Section 2(a)(i) hereof.

     Shelf Registration Statement: As defined in Section 2(a)(i) hereof.

     Suspension Period: As defined in Section 4(b)(i) hereof.

     TIA: Trust Indenture Act of 1939, as in effect on the date the Indenture is qualified
under the TIA.

     Transfer Restricted Securities: Each Note and each share of Common Stock issued upon
conversion of Notes until the earlier of:

     (i) the date on which such Note or such share of Common Stock issued upon conversion
has been effectively registered under the Securities Act and disposed of in accordance with
the Shelf Registration Statement;

     (ii) the date on which such Note or such share of Common Stock issued upon conversion
is transferred in compliance with Rule 144 under the Securities Act or may be sold or
transferred pursuant to Rule 144(k) under the Securities Act (or any other similar provision
then in force); or

     (iii) the date on which such Note or such share of Common Stock issued upon conversion
ceases to be outstanding (whether as a result of redemption, repurchase and cancellation,
conversion or otherwise).

     Underwritten Registration or Underwritten Offering: A registration in which
securities of the Issuer are sold to an underwriter for reoffering to the public.

     SECTION 2. Shelf Registration.

     (a) The Issuer shall:

     (i) not later than 90 days after the date hereof (the “Shelf Filing Deadline”),
cause to be filed a registration statement pursuant to Rule 415 under the Securities Act
(the “Shelf Registration Statement”), which Shelf Registration Statement shall
provide for resales of all Transfer Restricted Securities held by Holders that have provided
the information required pursuant to the terms of Section 2(b) hereof;

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     (ii) use its best efforts to cause the Shelf Registration Statement to be declared
effective by the Commission as promptly as is practicable, but in no event later than 180
days after the date hereof (the “Effectiveness Target Date”); and

     (iii) use its best efforts to keep the Shelf Registration Statement continuously
effective, supplemented and amended as required by the provisions of Section 4(b) hereof to
the extent necessary to ensure that it (A) is available for resales by the Holders of
Transfer Restricted Securities entitled to the benefit of this Agreement and (B) conforms
with the requirements of this Agreement and the Securities Act and the rules and regulations
of the Commission promulgated thereunder as announced from time to time for a period (the
“Effectiveness Period”) of:

     (1) two years after the date hereof; or

     (2) such shorter period that will terminate when (x) all of the Holders of
Transfer Restricted Securities are able to sell all Transfer Restricted Securities
immediately without restriction pursuant to Rule 144(k) under the Securities Act or
any successor rule thereto, (y) when all Transfer Restricted Securities have ceased
to be outstanding (whether as a result of redemption, repurchase and cancellation,
conversion or otherwise) or (z) all Transfer Restricted Securities registered under
the Shelf Registration Statement have been sold.

     (b) Subject to Section 2(c) below, no Holder may include any of its Transfer Restricted
Securities in the Shelf Registration Statement pursuant to this Agreement unless such Holder
furnishes to the Issuer in writing, prior to or on the 20th Business Day after receipt of a request
therefor (the “Questionnaire Deadline”), such information as the Issuer may reasonably
request, including the information specified in the form of questionnaire attached as Annex A to
the Offering Memorandum, for use in connection with the Shelf Registration Statement or the
Prospectus or preliminary Prospectus included therein and in any application to be filed with or
under state securities laws. In connection with all such requests for information from Holders in
addition to that set forth in Annex A to the Offering Memorandum, the Issuer shall notify such
Holders of the requirements set forth in the preceding sentence.

     (c) Beginning on the date the Shelf Registration Statement is declared effective, if necessary
to identify such Holder as a selling securityholder in the Shelf Registration Statement, the Issuer
shall:

     (i) (1) if permitted by the Commission to file a prospectus supplement, within 10
business days of receipt of a completed questionnaire, together with such other information
as the Issuer may reasonably request, file with the Commission a supplement to the related
Prospectus, or

          (2) within 30 days of receipt of a completed questionnaire, together with such other
information as the Issuer may reasonably request, file with the Commission a post-effective
amendment to the Shelf Registration Statement or file any other document required under the
Securities Act, and use its best efforts to cause such post-effective amendment to be
declared effective under the Securities Act as promptly as

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is practicable, but in any event by the date that is 30 days after the date such
post-effective amendment is required by this clause to be filed;

     (ii) provide such Holder copies of any documents filed pursuant to Section 2(c)(i); and

     (iii) notify such Holder as promptly as practicable after (i) the filing of such
prospectus supplement pursuant to Section 2(c)(i)(1), or (ii) the effectiveness under the
Securities Act of any post-effective amendment filed pursuant to Section 2(c)(i)(2);

provided that if such questionnaire is delivered during a Suspension Period, the Issuer
shall so inform the Holder delivering such questionnaire and shall take the actions set forth in
clauses (i), (ii) and (iii) above upon expiration of the Suspension Period; provided
further that in no event shall the Issuer be required to file a post-effective amendment to
the Shelf Registration Statement for the purpose of naming Holders as selling securityholders
pursuant to Section 2(c)(i)(2) until the date that is 30 days after the date the Issuer shall have
received questionnaires from Holders of Transfer Restricted Securities holding an aggregate of at
least $10 million aggregate principal amount of Transfer Restricted Securities; and
provided further that in no event will the Issuer be required to file a
post-effective amendment to the Shelf Registration Statement more frequently than once per fiscal
quarter. In connection with all such requests for information from Holders in addition to that set
forth in Annex A to the Offering Memorandum, the Issuer shall notify such Holders of the
requirements set forth in the preceding sentence.

     SECTION 3. Liquidated Damages.

     (a) If:

     (i) the Shelf Registration Statement is not filed with the Commission prior to or on
the Shelf Filing Deadline;

     (ii) the Shelf Registration Statement has not been declared effective by the Commission
prior to or on the Effectiveness Target Date;

     (iii) subject to the provisions of Section 4(b)(i) hereof, the Shelf Registration
Statement is filed and declared effective but, during the Effectiveness Period, shall
thereafter cease to be effective or fail to be usable for its intended purpose without being
succeeded within five Business Days by a post-effective amendment to the Shelf Registration
Statement or a report filed with the Commission pursuant to Section 13(a), 13(c), 14 or
15(d) of the Exchange Act that cures such failure and, in the case of a post-effective
amendment, is itself immediately declared effective; or

     (iv) prior to or on the 45th, 60th or 90th day, as the case may be, of any Suspension
Period, such suspension has not been terminated;

(each such event referred to in foregoing clauses (i) through (iv), a “Registration
Default”), the Issuer hereby agrees to pay liquidated damages (“Liquidated Damages”)
from and including the day following the Registration Default to but excluding the day on which the
Registration Default has been cured in respect of the Notes, to each holder of Notes, (x) with
respect to the

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first 90-day period during which a Registration Default shall have occurred and be continuing, in
an amount per year equal to an additional 0.25% of the principal amount of the Notes and (y) with
respect to the period commencing on the 91st day following the day the Registration Default shall
have occurred and be continuing, in an amount per year equal to an additional 0.50% of the
principal amount of the Notes; provided that in no event shall Liquidated Damages accrue at
a rate per year exceeding 0.50% of the principal amount of the Notes.

     (b) All accrued Liquidated Damages shall be paid in arrears to Record Holders by the Issuer on
each Damages Payment Date by wire transfer of immediately available funds or by federal funds
check. Following the cure of all Registration Defaults relating to any particular Note, the
accrual of Liquidated Damages with respect to such Note will cease. In no event shall Liquidated
Damages be paid to any Holder of a Note that has converted such Note into Common Stock.

     All obligations of the Issuer set forth in this Section 3 that are outstanding with respect to
any Transfer Restricted Security at the time such security ceases to be a Transfer Restricted
Security shall survive until such time as all such obligations with respect to such Transfer
Restricted Security shall have been satisfied in full.

     A Holder shall only be entitled to Liquidated Damages pursuant to Section 3(a)(iii) or Section
3(a)(iv) if such Holder shall have returned a completed questionnaire to the Issuer, together with
such other information as the Issuer may reasonably request.

     The Liquidated Damages set forth above shall be the exclusive monetary remedy available to the
Holders of Notes for such Registration Default.

     SECTION 4. Registration Procedures.

     (a) In connection with the Shelf Registration Statement, the Issuer shall comply with all the
provisions of Section 4(b) hereof and shall use its best efforts to effect such registration to
permit the resale of the Transfer Restricted Securities in accordance with the intended method or
methods of distribution thereof, and pursuant thereto, shall as expeditiously as possible prepare
and file with the Commission a Shelf Registration Statement relating to registration on any
appropriate form under the Securities Act.

     (b) In connection with the Shelf Registration Statement and any Prospectus required by this
Agreement to permit the resale of Transfer Restricted Securities, the Issuer shall:

     (i) Subject to any notice by the Issuer in accordance with this Section 4(b) of the
existence of any fact or event of the kind described in Section 4(b)(iii)(D), use its best
efforts to keep the Shelf Registration Statement continuously effective during the
Effectiveness Period. Upon the occurrence of any event that would cause the Shelf
Registration Statement or the Prospectus contained therein (A) to contain a material
misstatement or omission or (B) not be effective and usable for resale of Transfer
Restricted Securities during the Effectiveness Period, the Issuer shall file promptly an
appropriate amendment to the Shelf Registration Statement or a report filed with the
Commission pursuant to Section 13(a), 13(c), 14 or 15(d) of the Exchange Act, in the case of
clause (A), correcting any such misstatement or omission, and, in the case of

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either clause (A) or (B), use its best efforts to cause any such amendment to be
declared effective and the Shelf Registration Statement and the related Prospectus to become
usable for their intended purposes as soon as practicable thereafter. Notwithstanding the
foregoing, the Issuer may suspend the effectiveness of the Shelf Registration Statement by
written notice to the Holders for a period not to exceed 45 days in any 90-day period or an
aggregate of 90 days in any 360-day period (each such period, a “Suspension Period”)
if, in the Issuer’s reasonable judgment, it possesses material non-public information the
disclosure of which would have a material adverse effect on the business of the Issuer (and
its subsidiaries, if any, taken as a whole); provided, however, that in the
event the disclosure relates to a previously undisclosed proposed or pending material
business transaction, the disclosure of which would impede the Issuer’s ability to
consummate such transaction, the Issuer may extend a Suspension Period from 45 days to 60
days.

     (ii) Prepare and file with the Commission such post-effective amendments to the Shelf
Registration Statement as may be necessary to keep the Shelf Registration Statement
effective during the Effectiveness Period; cause the Prospectus to be supplemented by any
required Prospectus supplement, and as so supplemented to be filed pursuant to Rule 424
under the Securities Act, and to comply fully with the applicable provisions of Rules 424
and 430A under the Securities Act in a timely manner; and comply with the provisions of the
Securities Act with respect to the disposition of all securities covered by the Shelf
Registration Statement during the applicable period in accordance with the intended method
or methods of distribution by the sellers thereof set forth in the Shelf Registration
Statement or Prospectus supplement.

     (iii) Advise the selling Holders that have provided the information required by Section
4(d) of this Agreement, the Initial Purchasers, and the underwriter(s), if any, promptly
(but in any event within five Business Days) and, if requested by such Persons, confirm such
advice in writing:

     (A) with respect to the Shelf Registration Statement or any post-effective
amendment thereto, when the same has become effective, and when the Prospectus or
any Prospectus supplement or post-effective amendment has been filed,

     (B) of any request by the Commission for amendments to the Shelf Registration
Statement or amendments or supplements to the Prospectus or for additional
information relating thereto,

     (C) of the issuance by the Commission of any stop order suspending the
effectiveness of the Shelf Registration Statement under the Securities Act or of the
suspension by any state securities commission of the qualification of the Transfer
Restricted Securities for offering or sale in any jurisdiction, or the initiation of
any proceeding for any of the preceding purposes, or

     (D) of the existence of any fact or the happening of any event, during the
Effectiveness Period, that makes any statement of a material fact made in the

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Shelf Registration Statement or the Prospectus, any amendment or supplement
thereto, or any document incorporated by reference therein untrue, or that requires
the making of any additions to or changes in the Shelf Registration Statement or the
Prospectus in order to make the statements therein not misleading.

     If at any time the Commission shall issue any stop order suspending the effectiveness of the
Shelf Registration Statement, or any state securities commission or other regulatory authority
shall issue an order suspending the qualification or exemption from qualification of the Transfer
Restricted Securities under state securities or Blue Sky laws, the Issuer shall use its reasonable
best efforts to obtain the withdrawal or lifting of such order at the earliest possible time.

     (iv) Furnish to each of the selling Holders that have provided the information required
by Section 4(d) of this Agreement, the underwriter(s), if any, before filing with the
Commission, a copy of the Shelf Registration Statement and copies of any Prospectus included
therein or any amendments or supplements to the Shelf Registration Statement or Prospectus
(other than documents incorporated by reference after the initial filing of the Shelf
Registration Statement), which documents will be subject to the review of such Holders, the
Initial Purchasers and underwriter(s), if any, for a period of at least ten Business Days,
and the Issuer will not file any Shelf Registration Statement or Prospectus or any amendment
or supplement to the Shelf Registration Statement or Prospectus (other than documents
incorporated by reference) to which a selling Holder of Transfer Restricted Securities
covered by the Shelf Registration Statement, the Initial Purchasers, or the underwriter(s),
if any, shall reasonably object within five Business Days after the receipt thereof. A
selling Holder, the Initial Purchasers, or underwriter, if any, shall be deemed to have
reasonably objected to such filing if the Shelf Registration Statement, amendment,
Prospectus or supplement, as applicable, as proposed to be filed, contains a material
misstatement or omission. Notwithstanding the foregoing, the Issuer shall not be required
to furnish the selling Holders with any amendment or supplement to the Shelf Registration
Statement or Prospectus filed solely to reflect changes to the amount of Notes held by any
particular Holder at the request of such Holder or immaterial revisions to the information
contained therein.

     (v) If the selling Holders propose to make an underwritten public offering of the
Transfer Restricted Securities, subject to the proviso contained in Section 4(b)(ix), make
available at reasonable times for inspection by one or more representatives of the selling
Holders, designated in writing by a Majority of Holders whose Transfer Restricted Securities
are included in the Shelf Registration Statement, any underwriter participating in any
distribution pursuant to the Shelf Registration Statement and any attorney or accountant
retained by such selling Holders or any of the underwriter(s), all financial and other
records, pertinent corporate documents and properties of the Issuer as shall be reasonably
necessary to enable them to exercise any applicable due diligence responsibilities, and
cause the Issuer’s officers, directors, managers and employees to supply all information
reasonably requested by any such representative or representatives of the selling Holders,
underwriter, attorney or accountant in connection with the Shelf Registration Statement
after the filing thereof and before its effectiveness; provided, however,
that any information designated by the Issuer as confidential at the time of delivery of
such information shall be kept confidential by the recipient thereof.

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     (vi) If requested by any selling Holders, the Initial Purchasers or the underwriter(s),
if any, promptly incorporate in the Shelf Registration Statement or Prospectus, pursuant to
a supplement or post-effective amendment if necessary, such information as such selling
Holders, the Initial Purchasers, and such underwriter(s), if any, may reasonably request to
have included therein, including, without limitation: (1) information relating to the “Plan
of Distribution” of the Transfer Restricted Securities, (2) information with respect to the
principal amount of Notes or number of shares of Common Stock being sold to such
underwriter(s), if any, (3) the purchase price being paid therefor and (4) any other terms
of the offering of the Transfer Restricted Securities to be sold in such offering; and make
all required filings of such Prospectus supplement or post-effective amendment as soon as
reasonably practicable after the Issuer is notified of the matters to be incorporated in
such Prospectus supplement or post-effective amendment. Notwithstanding the foregoing,
following the effective date of the Shelf Registration Statement, the Issuer shall not be
required to file more than one such supplement or post-effective amendment to reflect
changes in the amount of Notes held by any particular Holder at the request of such Holder
in any 30-day period.

     (vii) Furnish to each selling Holder, the Initial Purchasers, and each of the
underwriter(s), if any, without charge, at least one copy of the Shelf Registration
Statement, as first filed with the Commission, and of each amendment thereto (and any
documents incorporated by reference therein or exhibits thereto (or exhibits incorporated in
such exhibits by reference) as such Person may request).

     (viii) Deliver to each selling Holder, the Initial Purchasers, and each of the
underwriter(s), if any, without charge, as many copies of the Prospectus (including each
preliminary prospectus) and any amendment or supplement thereto as such Persons reasonably
may request; subject to any notice by the Issuer in accordance with this Section 4(b) of the
existence of any fact or event of the kind described in Section 4(b)(iii)(D), the Issuer
hereby consents to the use of the Prospectus and any amendment or supplement thereto by each
of the selling Holders and each of the underwriter(s), if any, in connection with the
offering and the sale of the Transfer Restricted Securities covered by the Prospectus or any
amendment or supplement thereto.

     (ix) If an underwriting agreement is entered into and the registration is an
Underwritten Registration, the Issuer shall:

     (A) upon request, furnish to each selling Holder and the underwriter(s), if
any, in such substance and scope as they may reasonably request and as are
customarily made by issuers to underwriters in primary underwritten offerings, upon
the date of closing of any sale of Transfer Restricted Securities in an Underwritten
Registration: (1) a certificate, dated the date of such closing, signed by the
Chief Financial Officer of the Issuer confirming, as of the date thereof, the
matters set forth in Section 5(c) of the Purchase Agreement and such other matters
as such parties may reasonably request; (2) opinions, each dated the date of such
closing, of counsel to the Issuer covering such of the matters set forth in the
exhibits to the Purchase Agreement referred to in Section 5(a) thereof as are
customarily covered in legal opinions to underwriters in connection with primary

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underwritten offerings of securities; and (3) customary comfort letters, dated
the date of such closing, from the Issuer’s independent registered public accounting
firm (and from any other accountants whose report is contained or incorporated by
reference in the Shelf Registration Statement), in the customary form and covering
matters of the type customarily covered in comfort letters to underwriters in
connection with primary underwritten offerings of securities;

     (B) set forth in full in the underwriting agreement, if any, indemnification
provisions and procedures which provide rights no less protective than those set
forth in Section 6 hereof with respect to all parties to be indemnified;

     (C) deliver such other documents and certificates as may be reasonably
requested by such parties to evidence compliance with clause (A) above and with any
customary conditions contained in the underwriting agreement or other agreement
entered into by the selling Holders pursuant to this clause (ix);

provided, however, that the Issuer shall not be required to facilitate an
Underwritten Offering, as set forth in this subsection (ix), pursuant to the Shelf
Registration Statement by any Holders unless the offering relates to at least $50,000,000
principal amount of the Transfer Restricted Securities.

     (x) Before any public offering of Transfer Restricted Securities, cooperate with the
selling Holders, the underwriter(s), if any, and their respective counsel in connection with
the registration and qualification of the Transfer Restricted Securities under the
securities or Blue Sky laws of such jurisdictions as the selling Holders or underwriter(s),
if any, may reasonably request and do any and all other acts or things necessary or
advisable to enable the disposition in such jurisdictions of the Transfer Restricted
Securities covered by the Shelf Registration Statement; provided, however,
that the Issuer shall not be required (A) to register or qualify as a foreign corporation or
a dealer of securities where it is not now so qualified or to take any action that would
subject it to the service of process in any jurisdiction where it is not now so subject or
(B) to subject itself to taxation in any such jurisdiction if they are not now so subject.

     (xi) Cooperate with the selling Holders and the underwriter(s), if any, to facilitate
the timely preparation and delivery of certificates representing Transfer Restricted
Securities to be sold and, when issued to the purchasers of Transfer Restricted Securities
pursuant to the Shelf Registration Statement, not bearing any restrictive legends (unless
required by applicable securities laws); and enable such Transfer Restricted Securities to
be in such denominations and registered in such names as the selling Holders or the
underwriter(s), if any, may request at least two Business Days before any sale of Transfer
Restricted Securities made by the selling Holders or such underwriter(s).

     (xii) Use its best efforts to cause the Transfer Restricted Securities covered by the
Shelf Registration Statement to be registered with or approved by such other U.S.
governmental agencies or authorities as may be necessary to enable the seller or sellers

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thereof or the underwriter(s), if any, to consummate the disposition of such Transfer
Restricted Securities.

     (xiii) Subject to Section 4(b)(i) hereof, if any fact or event contemplated by Section
4(b)(iii)(D) hereof shall exist or have occurred, use its reasonable best efforts to prepare
a supplement or post-effective amendment to the Shelf Registration Statement or related
Prospectus or any document incorporated therein by reference or file any other required
document so that, as thereafter delivered to the purchasers of Transfer Restricted
Securities, the Prospectus will not contain an untrue statement of a material fact or omit
to state any material fact required to be stated therein or necessary to make the statements
therein not misleading.

     (xiv) Provide CUSIP numbers for all Transfer Restricted Securities not later than the
effective date of the Shelf Registration Statement and provide the Trustee under the
Indenture with certificates for the Notes that are in a form eligible for deposit with The
Depository Trust Company.

     (xv) Cooperate with respect to any filings required to be made with the NASD and in the
performance of any due diligence investigation by any underwriter that is required to be
retained in accordance with the rules and regulations of the NASD.

     (xvi) Otherwise use its best efforts to comply with all applicable rules and
regulations of the Commission and all reporting requirements under the rules and regulations
of the Exchange Act.

     (xvii) Cause the Indenture to be qualified under the TIA not later than the effective
date of the Shelf Registration Statement required by this Agreement, and, in connection
therewith, cooperate with the Trustee and the holders of Notes to effect such changes to the
Indenture as may be required for such Indenture to be so qualified in accordance with the
terms of the TIA; and execute and use its best efforts to cause the Trustee thereunder to
execute all documents that may be required to effect such changes and all other forms and
documents required to be filed with the Commission to enable such Indenture to be so
qualified in a timely manner.

     (xviii) Cause all Transfer Restricted Securities covered by the Shelf Registration
Statement to be listed or quoted, as the case may be, on each securities exchange or
automated quotation system on which similar securities issued by the Issuer are then listed
or quoted.

     (xix) Make available to each Holder upon written request each document filed with the
Commission pursuant to the requirements of Section 13 and Section 15 of the Exchange Act
after the effective date of the Shelf Registration Statement.

     (xx) Use its best efforts to obtain a waiver from each person who would otherwise have
the right to have securities of the Issuer (other than Transfer Restricted Securities)
registered on the Shelf Registration Statement required by this Agreement. To the extent
the Issuer does not receive such waivers, it will use its best efforts to obtain the consent
of such persons from whom waivers are not obtained to file a separate

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registration statement with respect to all such other registrable securities, rather
than include them in the Shelf Registration Statement and, upon receipt of such consent, to
register such registrable securities in accordance therewith.

     (c) Each Holder agrees by acquisition of a Transfer Restricted Security that, upon receipt of
any notice from the Issuer of the existence of any fact of the kind described in Section
4(b)(iii)(D) hereof, such Holder will, and will use its reasonable best efforts to cause any
underwriter(s) in an Underwritten Offering to, forthwith discontinue disposition of Transfer
Restricted Securities pursuant to the Shelf Registration Statement until:

     (i) such Holder has received copies of the supplemented or amended Prospectus
contemplated by Section 4(b)(xiii) hereof; or

     (ii) such Holder is advised in writing (the “Advice”) by the Issuer that the
use of the Prospectus may be resumed, and has received copies of any additional or
supplemental filings that are incorporated by reference in the Prospectus. If so directed
by the Issuer, each Holder will deliver to the Issuer (at the Issuer’s expense) all copies,
other than permanent file copies then in such Holder’s possession, of the Prospectus
covering such Transfer Restricted Securities that was current at the time of receipt of such
notice of suspension.

     (d) Each Holder who intends to be named as a selling Holder in the Shelf Registration
Statement shall furnish to the Issuer in writing, prior to or on the 20th Business Day after
receipt of a request therefor as set forth in a questionnaire, such information regarding such
Holder and the proposed distribution by such Holder of its Transfer Restricted Securities as the
Issuer may reasonably request for use in connection with the Shelf Registration Statement or
Prospectus or preliminary Prospectus included therein. The form of the questionnaire is attached
as Annex A to the Offering Memorandum. Holders that do not complete the questionnaire and deliver
it to the Issuer shall not be named as selling securityholders in the Prospectus or preliminary
Prospectus included in the Shelf Registration Statement and therefore shall not be permitted to
sell any Transfer Restricted Securities pursuant to the Shelf Registration Statement. Each Holder
who intends to be named as a selling Holder in the Shelf Registration Statement shall promptly
furnish to the Issuer in writing such other information as the Issuer may from time to time
reasonably request in writing. Each Holder as to which the Shelf Registration Statement is being
effected agrees to furnish promptly to the Issuer all information required to be disclosed in order
to make information previously furnished to the Issuer by such Holder not materially misleading.

     SECTION 5. Registration Expenses.

     (a) All expenses incident to the Issuer’s performance of or compliance with this Agreement
shall be borne by the Issuer regardless of whether a Shelf Registration Statement becomes
effective, including, without limitation:

     (i) all registration and filing fees and expenses (including filings made by any
Initial Purchasers, Holders or underwriters with the NASD);

     (ii) all fees and expenses of compliance with federal securities and state Blue Sky or
securities laws;

12

 

     (iii) all expenses of printing (including printing of Prospectuses and certificates for
the Common Stock to be issued upon conversion of the Notes), messenger and delivery services
and telephone;

     (iv) all fees and disbursements of counsel to the Issuer and, subject to Section 5(b)
below, the Holders of Transfer Restricted Securities;

     (v) all application and filing fees in connection with listing (or authorizing for
quotation) the Common Stock on a national securities exchange or automated quotation system
pursuant to the requirements hereof; and

     (vi) all fees and disbursements of independent registered public accounting firm of the
Issuer (including the expenses of any special audit and comfort letters required by or
incident to such performance).

The Issuer shall bear its internal expenses (including, without limitation, all salaries and
expenses of their officers and employees performing legal, accounting or other duties), the
expenses of any annual audit and the fees and expenses of any Person, including special experts,
retained by the Issuer.

     (b) In connection with the review of the Shelf Registration Statement and other documents
referred to in this Agreement, the Issuer shall, against a reasonably detailed invoice therefor,
reimburse the Initial Purchasers, and the Holders of Transfer Restricted Securities being
registered pursuant to the Shelf Registration Statement, for the reasonable fees and disbursements
of not more than one counsel, which shall be Shearman & Sterling LLP, or such other counsel as may
be chosen by a Majority of Holders for whose benefit the Shelf Registration Statement is being
prepared.

     SECTION 6. Indemnification and Contribution.

     (a) The Issuer agrees to indemnify and hold harmless each Initial Purchaser (and each of their
directors, officers and employees), each Holder whose securities are included in a Shelf
Registration Statement (and each of their directors, officers and employees), each Person who
participates as an underwriter (any such Person being an “Underwriter”) and each Person, if
any, who controls any Initial Purchaser, Holder or Underwriter within the meaning of either Section
15 of the Securities Act or Section 20 of the Exchange Act as follows:

     (i) against any and all loss, liability, claim, damage and expense whatsoever, as
incurred, arising out of any untrue statement or alleged untrue statement of a material fact
contained in such Shelf Registration Statement (or any amendment thereto), including all
documents incorporated therein by reference, or the omission or alleged omission therefrom
of a material fact required to be stated therein or necessary to make the statements therein
not misleading, or arising out of any untrue statement or alleged untrue statement of a
material fact contained in any Prospectus (or any amendment or supplement thereto) or the
omission or alleged omission therefrom of a material fact necessary in order to make the
statements therein, in the light of the circumstances under which they were made, not
misleading;

13

 

     (ii) against any and all loss, liability, claim, damage and expense whatsoever, as
incurred, to the extent of the aggregate amount paid in settlement of any litigation, or any
investigation or proceeding by any governmental agency or body, commenced or threatened, or
of any claim whatsoever based upon any such untrue statement or omission, or any such
alleged untrue statement or omission; provided, however, that (subject to
Section 6(d) below) any such settlement is effected with the written consent of the Issuer;
and

     (iii) against any and all expense whatsoever, as incurred (including the fees and
disbursements of counsel chosen by any indemnified party), reasonably incurred in
investigating, preparing or defending against any litigation, or any investigation or
proceeding by any governmental agency or body, commenced or threatened, or any claim
whatsoever based upon any such untrue statement or omission, or any such alleged untrue
statement or omission, to the extent that any such expense is not paid under subparagraph
(i) or (ii) above;

provided, however, that this indemnity agreement shall not apply to any loss,
liability, claim, damage or expense to the extent arising out of any untrue statement or omission
or alleged untrue statement or omission made in reliance upon and in conformity with written
information furnished to the Issuer by the Initial Purchasers, such Holder or such Underwriter
expressly for use in a Shelf Registration Statement (or any amendment thereto) or any Prospectus
(or any amendment or supplement thereto) and (y) with respect to any untrue statement or omission
or alleged untrue settlement or omission made in any preliminary prospectus relating to the Shelf
Registration Statement, the indemnity agreement contained in this subsection (a) shall not inure to
the benefit of any Holder from whom the person asserting any such losses, claims, damages or
liabilities purchased the Transfer Restricted Securities concerned, to the extent that a prospectus
relating to such Transfer Restricted Securities was required to be delivered by such Holder under
the Securities Act in connection with such purchase and any such loss, claim, damage or liability
of such Holder results from the fact that there was not sent or given to such person, at or prior
to the written confirmation of the sale of such Transfer Restricted Securities to such person, a
copy of the final prospectus if (1) the Issuer had previously furnished copies thereof to such
Holder and (2) such loss, claim, damage or liability of such Holder resulted from an untrue
statement or omission or alleged untrue settlement or omission contained in or omitted from the
preliminary prospectus which was corrected in the final prospectus; provided
further, however, that this indemnity agreement will be in addition to any
liability which the Issuer may otherwise have to such Indemnified Party.

     (b) Each Holder whose securities are included in a Shelf Registration Statement, severally but
not jointly, agrees to indemnify and hold harmless the Issuer (and its directors, officers and
employees), the Initial Purchasers (and each of their directors, officers and employees), each
Underwriter (and each of their directors, officers and employees) and the other selling Holders
(and each of their directors, officers and employees) and each Person, if any, who controls the
Issuer, the Initial Purchasers, any Underwriter or any other selling Holder within the meaning of
Section 15 of the Securities Act or Section 20 of the Exchange Act, against any and all loss,
liability, claim, damage and expense described in the indemnity contained in Section 6(a) hereof,
as incurred, but only with respect to untrue statements or omissions, or alleged untrue statements
or omissions, made in such Shelf Registration Statement (or any amendment

14

 

thereto) or any Prospectus (or any amendment or supplement thereto) in reliance upon and in
conformity with written information with respect to such Holder furnished to the Issuer by such
Holder expressly for use in such Shelf Registration Statement (or any amendment thereto) or such
Prospectus (or any amendment or supplement thereto); provided, however, that no
such Holder shall be liable for any claims hereunder in excess of the amount of net proceeds
received by such Holder from the sale of Transfer Restricted Securities pursuant to such Shelf
Registration Statement.

     (c) Each indemnified party shall give notice as promptly as reasonably practicable to each
indemnifying party of any action or proceeding commenced against it in respect of which indemnity
may be sought hereunder, but failure to so notify an indemnifying party shall not relieve such
indemnifying party from any liability hereunder to the extent it is not materially prejudiced as a
result thereof and in any event shall not relieve it from any liability which it may have otherwise
than on account of this indemnity agreement. An indemnifying party may participate at its own
expense in the defense of such action; provided, however, that counsel to the
indemnifying party shall not (except with the consent of the indemnified party) also be counsel to
the indemnified party. In no event shall the indemnifying party or parties be liable for the fees
and expenses of more than one counsel (in addition to any local counsel) separate from their own
counsel for all indemnified parties in connection with any one action or separate but similar or
related actions in the same jurisdiction arising out of the same general allegations or
circumstances. No indemnifying party shall, without the prior written consent of the indemnified
parties, settle or compromise or consent to the entry of any judgment with respect to any
litigation, or any investigation or proceeding by any governmental agency or body, commenced or
threatened, or any claim whatsoever in respect of which indemnification or contribution could be
sought under this Section 6 (whether or not the indemnified parties are actual or potential parties
thereto), unless such settlement, compromise or consent (i) includes an unconditional release of
each indemnified party from all liability arising out of such litigation, investigation, proceeding
or claim and (ii) does not include a statement as to or an admission of fault, culpability or a
failure to act by or on behalf of any indemnified party.

     (d) If at any time an indemnified party shall have requested an indemnifying party to
reimburse the indemnified party for fees and expenses of counsel, such indemnifying party agrees
that it shall be liable for any settlement of the nature contemplated by Section 6(a)(ii) effected
without its written consent if (i) such settlement is entered into more than 45 days after receipt
by such indemnifying party of the aforesaid request, (ii) such indemnifying party shall have
received notice of the terms of such settlement at least 30 days prior to such settlement being
entered into and (iii) such indemnifying party shall not have reimbursed such indemnified party in
accordance with such request prior to the date of such settlement.

     (e) If the indemnification provided for in this Section 6 is for any reason unavailable to or
insufficient to hold harmless an indemnified party in respect of any losses, liabilities, claims,
damages or expenses referred to therein, then each indemnifying party shall contribute to the
aggregate amount of such losses, liabilities, claims, damages and expenses incurred by such
indemnified party, as incurred, (i) in such proportion as is appropriate to reflect the relative
benefits received by the Issuer from the offering and sale of the Transfer Restricted Securities on
the one hand and a Holder with respect to the sale by the Holder of the Transfer Restricted
Securities on the other hand; or (ii) if the allocation provided by clause (i) is not permitted by

15

 

applicable law, in such proportion as is appropriate to reflect not only the relative benefits
referred to in clause (i) but also the relative fault of the indemnifying party or parties on the
one hand and the indemnified party or parties on the other hand in connection with the statements
or omissions which resulted in such losses, liabilities, claims, damages or expenses, as well as
any other relevant equitable considerations.

     The relative benefits received by the Issuer on the one hand and a Holder on the other hand
with respect to such offering and such sale shall be deemed to be in the same proportion as the
total net proceeds from the offering of the Notes purchased under the Purchase Agreement (before
deducting expenses) received by the Issuer, as set forth in the Offering Memorandum on the one hand
bear to the total net proceeds received by such Holder with respect to its sale of Transfer
Restricted Securities on the other. The relative fault of the indemnifying party or parties on the
one hand and the indemnified party or parties on the other hand shall be determined by reference
to, among other things, whether any such untrue or alleged untrue statement of a material fact or
omission or alleged omission to state a material fact relates to information supplied by the
indemnifying party or parties on the one hand or the indemnified party or parties on the other hand
and the parties’ relative intent, knowledge, access to information and opportunity to correct or
prevent such statement or omission.

     The parties hereto agree that it would not be just and equitable if contribution pursuant to
this Section 6 were determined by pro rata allocation or by any other method of allocation which
does not take account of the equitable considerations referred to above in this Section 6. The
aggregate amount of losses, liabilities, claims, damages and expenses incurred by an indemnified
party and referred to above in this Section 6 shall be deemed to include any legal or other
expenses reasonably incurred by such indemnified party in investigating, preparing or defending
against any litigation, or any investigation or proceeding by any governmental agency or body,
commenced or threatened, or any claim whatsoever based upon any such untrue or alleged untrue
statement or omission or alleged omission.

     Notwithstanding the provisions of this Section 6, no Holder shall be required to contribute
any amount in excess of the amount by which the total price at which the Transfer Restricted
Securities purchased by it were resold exceeds the amount of any damages which such Holder has
otherwise been required to pay by reason of any untrue or alleged untrue statement or omission or
alleged omission. The Holders’ obligations to contribute as provided in this Section 6(e) are
several and not joint. No Person guilty of fraudulent misrepresentation (within the meaning of
Section 11(f) of the Securities Act) shall be entitled to contribution from any Person who was not
guilty of such fraudulent misrepresentation.

     For purposes of this Section 6, each Person, if any, who controls an Initial Purchaser, a
Holder or an Underwriter within the meaning of Section 15 of the Securities Act or Section 20 of
the Exchange Act shall have the same rights to contribution as such Initial Purchaser, such Holder
or such Underwriter, and each director of the Issuer, and each Person, if any, who controls the
Issuer within the meaning of Section 15 of the Securities Act or Section 20 of the Exchange Act
shall have the same rights to contribution as the Issuer.

     SECTION 7. Rule 144A. In the event the Issuer is not subject to Section 13 or 15(d)
of the Exchange Act, the Issuer hereby agrees with each Holder, for so long as any Transfer

16

 

Restricted Securities remain outstanding, to make available to any Holder or beneficial owner
of Transfer Restricted Securities in connection with any sale thereof and any prospective purchaser
of such Transfer Restricted Securities from such Holder or beneficial owner, the information
required by Rule 144A(d)(4) under the Securities Act in order to permit resales of such Transfer
Restricted Securities pursuant to Rule 144A.

     SECTION 8. Participation in Underwritten Registrations. No Holder may participate in
any Underwritten Registration hereunder unless such Holder:

     (i) agrees to sell such Holder’s Transfer Restricted Securities on the basis provided
in any underwriting arrangements approved by the Persons entitled hereunder to approve such
arrangements, and

     (ii) completes and executes all reasonable questionnaires, powers of attorney,
indemnities, underwriting agreements, lock-up letters and other documents required under the
terms of such underwriting arrangements.

     SECTION 9. Selection of Underwriters. Subject to the proviso contained in Section
4(b)(ix), the Holders of Transfer Restricted Securities covered by the Shelf Registration Statement
who desire to do so may sell such Transfer Restricted Securities in an Underwritten Offering. In
any such Underwritten Offering, the investment banker or investment bankers and manager or managers
that will administer the offering will be selected by a Majority of Holders whose Transfer
Restricted Securities are included in such offering; provided that such investment bankers and
managers must be reasonably satisfactory to the Issuer.

     SECTION 10. Miscellaneous.

     (a) Remedies. The Issuer acknowledges and agrees that any failure by the Issuer to
comply with its obligations under Section 2 hereof may result in material irreparable injury to the
Initial Purchasers or the Holders for which there is no adequate remedy at law, that it will not be
possible to measure damages for such injuries precisely and that, in the event of any such failure,
the Initial Purchasers or any Holder may obtain such relief as may be required to specifically
enforce the Issuer’s obligations under Section 2 hereof. The Issuer further agrees to waive the
defense in any action for specific performance that a remedy at law would be adequate.

     (b) Adjustments Affecting Transfer Restricted Securities. The Issuer shall not,
directly or indirectly, take any action with respect to the Transfer Restricted Securities as a
class that would adversely affect the ability of the Holders to include such Transfer Restricted
Securities in a registration undertaken pursuant to this Agreement.

     (c) No Inconsistent Agreements. The Issuer will not, on or after the date of this
Agreement, enter into any agreement with respect to its securities that is inconsistent with the
rights granted to the Holders in this Agreement or otherwise conflicts with the provisions hereof.
In addition, the Issuer shall not, on or after the date hereof, grant to any of its security
holders (other than the holders of Transfer Restricted Securities in such capacity) the right to
include any of its securities in the Shelf Registration Statement provided for in this Agreement
other than the Transfer Restricted Securities. Except as disclosed in the Offering Memorandum
dated August 4, 2005 relating to the Notes, the Issuer has not previously entered into any
agreement (which

17

 

has not expired or been terminated) granting any registration rights with respect to its
securities to any Person which rights conflict with the provisions hereof.

     (d) Amendments and Waivers. This Agreement may not be amended, modified or
supplemented, and waivers or consents to or departures from the provisions hereof may not be given,
unless the Issuer has obtained the written consent of a Majority of Holders.

     (e) Notices. All notices and other communications provided for or permitted hereunder
shall be made in writing by hand delivery, first-class mail (registered or certified, return
receipt requested), telex, telecopier, or air courier guaranteeing overnight delivery:

     (i) if to a Holder, at the address set forth on the records of the registrar under the
Indenture or the transfer agent of the Common Stock, as the case may be; and

     (ii) if to the Issuer:

Human Genome Sciences, Inc.

14200 Shady Grove Road

Rockville, Maryland 20850

Attention: General Counsel

With a copy (which shall not constitute notice) to:

DLA Piper Rudnick Gray Cary US LLP

6225 Smith Avenue

Baltimore, Maryland 21209

Attention: R.W. Smith, Jr., Esq.

All such notices and communications shall be deemed to have been duly given: at the time delivered
by hand, if personally delivered; five Business Days after being deposited in the mail, postage
prepaid, if mailed; when answered back, if telexed; when receipt acknowledged, if telecopied; and
on the next Business Day, if timely delivered to an air courier guaranteeing overnight delivery.

     (f) Successors and Assigns. This Agreement shall inure to the benefit of and be
binding upon the successors and assigns of each of the parties, including, without limitation and
without the need for an express assignment, subsequent Holders of Transfer Restricted Securities;
provided, however, that (i) this Agreement shall not inure to the benefit of or be
binding upon a successor or assign of a Holder unless and to the extent such successor or assign
acquired Transfer Restricted Securities from such Holder and (ii) nothing contained herein shall be
deemed to permit any assignment, transfer or other disposition of Transfer Restricted Securities in
violation of the terms of the Purchase Agreement or the Indenture. If any transferee of any Holder
shall acquire Transfer Restricted Securities, in any manner, whether by operation of law or
otherwise, such Transfer Restricted Securities shall be held subject to all of the terms of this
Agreement, and by taking and holding such Transfer Restricted Securities such person shall be
conclusively deemed to have agreed to be bound by and to perform all of the terms and provisions of
this Agreement.

18

 

     (g) Counterparts. This Agreement may be executed in any number of counterparts and by
the parties hereto in separate counterparts, each of which when so executed shall be deemed to be
an original and all of which taken together shall constitute one and the same agreement.

     (h) Securities Held by the Issuer or Their Affiliates. Whenever the consent or
approval of Holders of a specified percentage of Transfer Restricted Securities is required
hereunder, Transfer Restricted Securities held by the Issuer or its “affiliates” (as such term is
defined in Rule 405 under the Securities Act) shall not be counted in determining whether such
consent or approval was given by the Holders of such required percentage.

     (i) Headings. The headings in this Agreement are for convenience of reference only
and shall not limit or otherwise affect the meaning hereof.

     (j) Governing Law. This Agreement shall be governed by, and construed in accordance
with, the law of the State of New York.

     (k) Severability. If any one or more of the provisions contained herein, or the
application thereof in any circumstance, is held invalid, illegal or unenforceable, the validity,
legality and enforceability of any such provision in every other respect and of the remaining
provisions contained herein shall not be affected or impaired thereby.

     (l) Entire Agreement. This Agreement is intended by the parties as a final expression
of their agreement and intended to be a complete and exclusive statement of the agreement and
understanding of the parties hereto in respect of the subject matter contained herein. There are
no restrictions, promises, warranties or undertakings, other than those set forth or referred to
herein with respect to the registration rights granted by the Issuer with respect to the Transfer
Restricted Securities. This Agreement supersedes all prior agreements and understandings between
the parties with respect to such subject matter.

[Remainder of page intentionally left blank]

19

 

     IN WITNESS WHEREOF, the parties have executed this Registration Rights Agreement as of the
date first written above.

	 	 	 	 	 
	 	Very truly yours,

HUMAN GENOME SCIENCES, INC.

 	 
	 	By:  	/s/ Steven C. Mayer
 	 
	 	 	Name:  	Steven C. Mayer 	 
	 	 	Title:  	Executive Vice President and CFO 	 
	 

Agreed and accepted as of the date first

above written:

	 	 	 	 	 	 	 
	CITIGROUP GLOBAL MARKETS INC.	 	 	 	 
	 
	 	 	 	 	 	 
	By:

	 	/s/ Trygve Mikkelsen	 	 	 	 
	 

	 	 	 	 	 	 
	 

	 	Name: Trygve Mikkelsen	 	 	 	 
	 

	 	Title: Managing Director	 	 	 	 
	 
	 	 	 	 	 	 
	MERRILL LYNCH, PIERCE, FENNER & SMITH INCORPORATED	 	 	 	 
	 
	 	 	 	 	 	 
	By:

	 	/s/ Anthony J. Gibney	 	 	 	 
	 

	 	 	 	 	 	 
	 

	 	Name: Anthony J. Gibney	 	 	 	 
	 

	 	Title: Director	 	 	 	 

20exv10w1

 

Exhibit 10.1

EXECUTION COPY

 

HUMAN GENOME SCIENCES, INC.

(a Delaware corporation)

2 1/4% Convertible Subordinated Notes due 2012

PURCHASE AGREEMENT

Dated: August 4, 2005

 

 

 

HUMAN GENOME SCIENCES, INC.

(a Delaware corporation)

$230,000,000

2 1/4% Convertible Subordinated Notes due 2012

PURCHASE AGREEMENT

August 4, 2005

Merrill Lynch, Pierce, Fenner & Smith Incorporated

Citigroup Global Markets Inc.

c/o Merrill Lynch, Pierce, Fenner & Smith Incorporated

4 World Financial Center

New York, New York 10080

Ladies and Gentlemen:

     Human Genome Sciences, Inc., a Delaware corporation (the “Company”), confirms its agreement
with Merrill Lynch, Pierce, Fenner & Smith Incorporated (“Merrill Lynch”) and Citigroup Global
Markets Inc. (“Citigroup,” collectively, the “Initial Purchasers,” which term shall also include
any Initial Purchaser substituted as hereinafter provided in Section 11 hereof), for whom Merrill
Lynch is acting as representative (in such capacity, the “Representative”), with respect to the
issue and sale by the Company and the purchase by the Initial Purchasers, acting severally and not
jointly, of the respective principal amounts set forth in Schedule A hereto of $230,000,000
aggregate principal amount of the Company’s 2 1/4% Convertible Subordinated Notes due 2012 (the
“Securities”). The Securities are to be issued pursuant to an indenture dated as of August 9, 2005
(the “Indenture”) between the Company and The Bank of New York, as trustee (the “Trustee”).

     The Securities are convertible into shares of common stock, par value $0.01 per share, of the
Company (the “Common Stock”) in accordance with the terms of the Securities and the Indenture, at
the initial conversion price specified in Schedule B hereto.

     The Company understands that the Initial Purchasers propose to make an offering of the
Securities on the terms and in the manner set forth herein and agrees that the Initial Purchasers
may resell, subject to the conditions set forth herein, all or a portion of the Securities to
purchasers (“Subsequent Purchasers”) at any time after this Agreement has been executed and
delivered. The Securities are to be offered and sold through the Initial Purchasers without being
registered under the Securities Act of 1933, as amended (the “1933 Act”), in reliance upon
exemptions therefrom. Pursuant to the terms of the Securities and the Indenture, investors that
acquire Securities may only resell or otherwise transfer such Securities if such Securities are
hereafter registered under the 1933 Act or if an exemption from the registration requirements of

2

 

the 1933 Act is available (including the exemption afforded by Rule 144A (“Rule 144A”) of the
rules and regulations promulgated under the 1933 Act (the “1933 Act Regulations”) by the Securities
and Exchange Commission (the “Commission”)). On or prior to the Closing Time (as defined below),
the Company will enter into an agreement with the Initial Purchasers (the “Registration Rights
Agreement”) pursuant to which, subject to the conditions set forth therein, the Company is required
to file and use its reasonable best efforts to have declared effective a registration statement
under the 1933 Act (the “Registration Statement”) to register resales of the Securities and the
shares of Common Stock issuable upon conversion thereof.

     The Company has prepared and delivered to each Initial Purchaser copies of a preliminary
offering memorandum dated August 3, 2005 (the “Preliminary Offering Memorandum”) and has prepared
and will deliver to each Initial Purchaser, on the date hereof or the next succeeding day, copies
of a final offering memorandum dated August 4, 2005 (the “Final Offering Memorandum”), each for use
by such Initial Purchaser in connection with its solicitation of purchases of, or offering of, the
Securities. “Offering Memorandum” means, with respect to any date or time referred to in this
Agreement, the most recent offering memorandum (whether the Preliminary Offering Memorandum or the
Final Offering Memorandum, or any amendment or supplement to either such document), including
exhibits thereto and any documents incorporated therein by reference, which has been prepared and
delivered by the Company to the Initial Purchasers in connection with their solicitation of
purchases of, or offering of, the Securities.

     All references in this Agreement to financial statements and schedules and other information
which is “contained,” “included” or “stated” in the Offering Memorandum (or other references of
like import) shall be deemed to mean and include all such financial statements and schedules and
other information which are incorporated by reference in the Offering Memorandum; and all
references in this Agreement to amendments or supplements to the Offering Memorandum shall be
deemed to mean and include the filing of any document under the Securities Exchange Act of 1934, as
amended (the “Exchange Act”), which is incorporated by reference in the Offering Memorandum.

     SECTION 1. Representations and Warranties.

     (a) Representations and Warranties by the Company. The Company represents and warrants to
each Initial Purchaser as of the date hereof, as of the Closing Time referred to in Section 2(b)
hereof and agrees with each Initial Purchaser, as follows:

          (i) Offering Memorandum. The Offering Memorandum does not, and at the Closing
Time will not, include an untrue statement of a material fact or omit to state a material
fact necessary in order to make the statements therein, in the light of the circumstances
under which they were made, not misleading. The preceding sentence does not apply to
statements in or omissions from the Offering Memorandum based upon written information
furnished to the Company by any Initial Purchaser through Merrill Lynch specifically for
use therein. Except as disclosed in the Offering Memorandum, on the date of this
Agreement, the Company’s Annual Report on Form 10-K most recently filed with the
Commission, the Company’s Quarterly Report on Form 10-Q most recently filed with the
Commission, the description of Common Stock contained in the Company’s Registration
Statement on Form 8-A and each of the Company’s Current Reports on Form 8-K (other than
such Current Reports on Form 8-K which are not deemed “filed” for the purposes of Section
18 of the Exchange Act) filed since the end of the fiscal year to which such Annual Report
relates (collectively, the “Exchange Act

3

 

Reports”) which have been filed by the Company with the Commission or sent to
stockholders pursuant to the Exchange Act and the rules and regulations of the Commission
thereunder (the “Exchange Act Regulations”) prior to or as of the date hereof do not
include any untrue statement of a material fact or omit to state any material fact
necessary to make the statements therein, in the light of the circumstances under which
they were made, not misleading. Such documents, when they were filed with the Commission,
conformed in all material respects to the requirements of the Exchange Act and the Exchange
Act Regulations.

          (ii) Independent Accountants. The accountants who certified the financial
statements and supporting schedules included in the Offering Memorandum are independent
public accountants with respect to the Company and its subsidiaries within the meaning of
Regulation S-X under the 1933 Act and the 1933 Act Regulations.

          (iii) Financial Statements. The financial statements incorporated by
reference in the Offering Memorandum present fairly the financial position of the Company
as of the dates shown and their results of operations and cash flows for the periods shown,
and such financial statements have been prepared in conformity with generally accepted
accounting principles in the United States applied on a consistent basis.

          (iv) No Material Adverse Change in Business. Except as disclosed in the
Offering Memorandum, since the date of the latest audited financial statements included in
the Offering Memorandum there has been no material adverse change, nor any development or
event involving a prospective material adverse change, in the condition (financial or
other), business, business prospects, properties or results of operations of the Company,
and, except as disclosed in or contemplated by the Offering Memorandum, there has been no
dividend or distribution of any kind declared, paid or made by the Company on any class of
its capital stock.

          (v) Good Standing of the Company. The Company has been duly incorporated and
is an existing corporation in good standing under the laws of the State of Delaware, with
power and authority (corporate and other) to own its properties and conduct its business as
described in the Offering Memorandum; and the Company is duly qualified to do business as a
foreign corporation in good standing in all other jurisdictions in which its ownership or
lease of property or the conduct of its business requires such qualification.

          (vi) Good Standing of Subsidiaries. Each subsidiary of the Company has been
duly organized and is validly existing as a corporation or other entity in good standing
under the laws of the jurisdiction of its incorporation or organization, has corporate or
other power and authority to own, lease and operate its properties and to conduct its
business as described in the Offering Memorandum and is duly qualified as a foreign
corporation to transact business and is in good standing in each jurisdiction in which such
qualification is required, whether by reason of the ownership or leasing of property or the
conduct of business.

          (vii) Capitalization. When the Securities are delivered and paid for pursuant
to this Agreement at the Closing Time, such Securities will be convertible into shares of
Common Stock of the Company in accordance with the terms of the Indenture; the shares of
Common Stock initially issuable upon conversion of such Securities have been duly
authorized and reserved for issuance upon such conversion and, when issued upon such

4

 

conversion, will be validly issued, fully paid and nonassessable and will conform to
the description thereof contained in the Offering Memorandum; the outstanding shares of
Common Stock have been duly authorized and validly issued, are fully paid and
nonassessable; and the stockholders of the Company have no preemptive rights with respect
to the Securities or the Common Stock.

          (viii) Authorization of this Agreement. This Agreement has been duly
authorized, executed and delivered by the Company.

          (ix) Authorization of the Indenture, Registration Rights Agreement and
Securities. Each of the Indenture and the Registration Rights Agreement has been duly
authorized; the Securities have been duly authorized; and when the Securities are delivered
and paid for pursuant to this Agreement at the Closing Time, the Indenture and the
Registration Rights Agreement will have been duly executed and delivered, such Securities
will have been duly executed, authenticated, issued and delivered and will conform to the
descriptions thereof contained in the Offering Memorandum and the Indenture, the
Registration Rights Agreement and such Securities will constitute valid and legally binding
obligations of the Company, enforceable in accordance with their terms, subject to
bankruptcy, insolvency, fraudulent transfer, reorganization, moratorium and similar laws of
general applicability relating to or affecting creditors’ rights and to general equity
principles.

          (x) Absence of Defaults and Conflicts. The execution, delivery and
performance of the Indenture, the Registration Rights Agreement and this Agreement, and the
issuance and sale of the Securities and compliance with the terms and provisions thereof
will not result in a breach or violation of any of the terms and provisions of, or
constitute a default under, any statute, any rule, regulation or order of any governmental
agency or body or any court, domestic or foreign, having jurisdiction over the Company, or
any of its subsidiaries, or any of their properties, or any agreement or instrument to
which the Company or any of its subsidiaries is a party or by which the Company or any of
its subsidiaries are bound or to which any of the properties of the Company or any of its
subsidiaries are subject, or the charter or by-laws of the Company or any of its
subsidiaries, and the Company has full power and authority to authorize, issue and sell the
Securities as contemplated by this Agreement.

          (xi) Absence of Labor Dispute. No labor disputes with the employees of the
Company or any of its subsidiaries exist or, to the knowledge of the Company, are imminent
that might have a Material Adverse Effect.

          (xii) Absence of Proceedings. Except as disclosed in the Offering Memorandum,
there are no pending actions, suits or proceedings against or affecting the Company or any
of its properties that, if determined adversely to the Company, would individually or in
the aggregate have a material adverse effect on the condition (financial or otherwise),
business, properties or results of operations of the Company (“Material Adverse Effect”),
or would materially and adversely affect the ability of the Company to perform its
obligations under the Indenture or this Agreement; and no such actions, suits or
proceedings are, to the Company’s knowledge, threatened or contemplated.

          (xiii) Intellectual Property. Except as disclosed in the Offering Memorandum,
the Company and its subsidiaries own or possess, or can acquire on reasonable terms,
patents, inventions, copyrights, know-how (including trade secrets and other unpatented

5

 

and/or unpatentable proprietary or confidential information, systems or procedures),
trademarks, service marks, trade names or other intellectual property (collectively,
“Intellectual Property”) necessary to carry on the business as described in the Offering
Memorandum. Except as disclosed in the Offering Memorandum, neither the Company nor any of
its subsidiaries has received any notice of any claim by a third party against them
alleging infringement of, interference with or any other conflict with asserted rights of
others with respect to any Intellectual Property, which (if the subject of any unfavorable
decision, ruling or finding), singly or in the aggregate, would result in a Material
Adverse Effect.

          (xiv) Absence of Further Requirements. No consent, approval, authorization,
or order of, or filing with, any governmental agency or body or any court is required for
the consummation of the transactions contemplated by this Agreement and the Registration
Rights Agreement in connection with the issuance and sale of the Securities by the Company,
except in connection with the registration of the Securities and the qualification of the
Indenture pursuant to the Registration Rights Agreement, and except as to state securities
laws.

          (xv) Possession of Licenses and Permits. The Company possesses adequate
certificates, licenses, authorities or permits issued by appropriate governmental agencies
or bodies necessary to conduct the business now operated by it and has not received any
notice of proceedings relating to the revocation or modification of any such certificate,
license, authority or permit that, if determined adversely to the Company, would
individually or in the aggregate have a Material Adverse Effect.

          (xvi) Title to Property. Except as disclosed in the Offering Memorandum, the
Company has good and marketable title to all real properties and all other properties and
assets owned by it, in each case free from liens, encumbrances and defects that would
materially affect the value thereof or materially interfere with the use made or to be made
thereof by the Company; and except as disclosed in the Offering Memorandum, the Company
holds any leased real or personal property under valid and enforceable leases with no
exceptions that would materially interfere with the use made or to be made thereof by it.

          (xvii) Environmental Laws. Except as disclosed in the Offering Memorandum,
the Company or any of its subsidiaries is not in violation of any statute, rule,
regulation, decision or order of any governmental agency or body or any court, domestic or
foreign, relating to the use, disposal or release of hazardous or toxic substances or
relating to the protection or restoration of the environment or human exposure to hazardous
or toxic substances (collectively, “environmental laws”), does not own or operate any real
property contaminated with any substance that is subject to any environmental laws at
levels or in quantities that could reasonably be expected to require remediation, is not
liable for any off-site disposal or contamination pursuant to any environmental laws, and
is not subject to any claim relating to any environmental laws, which violation,
contamination, liability or claim is expected, individually or in the aggregate, to have a
Material Adverse Effect; and the Company is not aware of any pending investigation which
might lead to such a claim.

          (xviii) Investment Company Act. The Company is not an open-end investment
company, unit investment trust or face-amount certificate company that is or is required to
be registered under Section 8 of the Investment Company Act of 1940, as amended

6

 

(the “Investment Company Act”); and the Company is not and, after giving effect to the
offering and sale of the Securities and the application of the proceeds thereof as
described in the Offering Memorandum, will not be an “investment company” as defined in the
Investment Company Act.

          (xix) Accounting Controls. (i) The Company and each of its subsidiaries
maintains a system of internal accounting controls sufficient to provide reasonable
assurances that (A) transactions are executed in accordance with management’s general or
specific authorization; (B) transactions are recorded as necessary to permit preparation of
financial statements in conformity with generally accepted accounting principles and to
maintain accountability for assets; (C) access to assets is permitted only in accordance
with management’s general or specific authorization; and (D) the recorded accountability
for assets is compared with existing assets at reasonable intervals and appropriate action
is taken with respect to any differences, and (ii) the Company maintains a system of
“disclosure controls and procedures” (as such term is defined in Rule 13a-14(c) under the
Exchange Act).

          (xx) Sarbanes-Oxley Act. The Company is in substantial compliance with the
applicable provisions of the Sarbanes-Oxley Act of 2002.

          (xxi) No Brokerage Commission; Finder’s Fee. Except as disclosed in the
Offering Memorandum, there are no contracts, agreements or understandings between the
Company and any person that would give rise to a valid claim against the Company or any
Initial Purchaser for a brokerage commission, finder’s fee or other like payment in
connection with the sale of the Securities.

          (xxii) Similar Offerings. Neither the Company nor any of its affiliates, as
such term is defined in Rule 501(b) under the 1933 Act (each, an “Affiliate”), has,
directly or indirectly, solicited any offer to buy, sold or offered to sell or otherwise
negotiated in respect of, or will solicit any offer to buy, sell or offer to sell or
otherwise negotiate in respect of, in the United States or to any United States citizen or
resident, any security which is or would be integrated with the sale of the Securities in a
manner that would require the offered Securities to be registered under the 1933 Act.

          (xxiii) Rule 144A Eligibility. No securities of the same class (with the
meaning of Rule 144A(d)(3) under the 1933 Act) as the offered Securities are listed on a
national securities exchange registered under Section 6 of the Exchange Act, or quoted in a
U.S. automated interdealer quotation system.

          (xxiv) No General Solicitation. None of the Company, its Affiliates or any
person acting on its or any of their behalf (other than the Initial Purchasers, as to whom
the Company makes no representation) has engaged or will engage, in connection with the
offering of the offered Securities, in any form of general solicitation or general
advertising within the meaning of Rule 502(c) under the 1933 Act. The Company has not
entered and will not enter into any contractual arrangement with respect to the
distribution of the Securities except for this Agreement

          (xxv) No Registration Required. Subject to compliance by the Initial
Purchasers with the representations and warranties set forth in Section 2 and the
procedures set forth in Section 6 hereof, it is not necessary in connection with the offer,
sale and delivery of the offered Securities to the Initial Purchasers and to each

7

 

Subsequent Purchaser in the manner contemplated by this Agreement and the Offering
Memorandum to register the Securities under the 1933 Act or to qualify the Indenture under
the 1939 Act.

          (xxvi) Absence of Manipulation. Neither the Company nor any affiliate (within
the meaning of Regulation M under the 1933 Act) of the Company has taken, nor will the
Company or any affiliate take, directly or indirectly, any action which is designed to or
which has constituted or which would be expected to cause or result in stabilization or
manipulation of the price of any security of the Company to facilitate the sale or resale
of the Securities.

          (xxvii) ERISA. The Company is in compliance in all material respects with all
presently applicable provisions of the Employee Retirement Income Security Act of 1974, as
amended, including the regulations and published interpretations thereunder (“ERISA”); no
“reportable event” (as defined in ERISA) has occurred with respect to any “pension plan”
(as defined in ERISA) for which the Company would have any liability; the Company has not
incurred and does not currently expect to incur material liability under (A) Title IV of
ERISA with respect to the termination of, or withdrawal from, any “pension plan” or (B)
Section 412 or 4971 of the Internal Revenue Code of 1986, as amended, including the
regulations and published interpretations thereunder (the “Code”); and each “pension plan”
for which the Company would have any liability that is intended to be qualified under
Section 401(a) of the Code is so qualified in all material respects and nothing has
occurred, whether by action or by failure to act, which would cause the loss of such
qualification.

          (xxviii) Reporting Company. The Company is subject to the reporting
requirements of Section 13 or Section 15(d) of the Exchange Act. The Common Stock is
registered pursuant to Section 12(g) of the 1934 Act and is quoted on the Nasdaq National
Market (the “NASDAQ”) and the Company has taken no action designed to, or likely to have
the effect of, terminating the registration of the Common Stock under the 1934 Act or
delisting the Common Stock from the NASDAQ, nor has the Company received any notification
that the Commission or the National Association of Securities Dealers, Inc. (the “NASD”) is
contemplating terminating such registration or listing.

          (xxix) Insurance. The Company and each of its subsidiaries carry, or are
covered by, insurance in such amounts and covering such risks as is adequate for the
conduct of their respective businesses and the value of their respective properties and as
is customary for companies engaged in similar businesses in similar industries.

     (b) Officer’s Certificates. Any certificate signed by any officer of the Company or any of
its subsidiaries delivered to the Representative or to counsel for the Initial Purchasers shall be
deemed a representation and warranty by the Company to each Initial Purchaser as to the matters
covered thereby.

     SECTION 2. Sale and Delivery to Initial Purchasers; Closing.

     (a) Securities. On the basis of the representations and warranties herein contained and
subject to the terms and conditions herein set forth, the Company agrees to sell to each Initial
Purchaser, severally and not jointly, and each Initial Purchaser, severally and not jointly, agrees
to purchase from the Company, at the price set forth in Schedule B, the aggregate principal amount
of Securities set forth in Schedule A opposite the name of such Initial Purchaser.

8

 

     (b) Payment. Payment of the purchase price for, and delivery of certificates for, the
Securities shall be made at the offices of Shearman & Sterling
LLP , 599 Lexington Avenue,
New York, NY 10022, or at such other place as shall be agreed upon by the Representative and the
Company, at 9:00 A.M. (Eastern time) on the third (fourth, if the pricing occurs after 4:30 P.M.
(Eastern time) on any given day) business day after the date hereof (unless postponed in accordance
with the provisions of Section 11), or such other time not later than ten business days after such
date as shall be agreed upon by the Representative and the Company (such time and date of payment
and delivery being herein called “Closing Time”).

     Payment shall be made to the Company by wire transfer of immediately available funds to a bank
account designated by the Company, against delivery to the Representative for the respective
accounts of the Initial Purchasers of certificates for the Securities to be purchased by them. It
is understood that each Initial Purchaser has authorized the Representative, for its account, to
accept delivery of, receipt for, and make payment of the purchase price for, the Securities which
it has agreed to purchase. Merrill Lynch, individually, and not as Representative of the Initial
Purchasers, may (but shall not be obligated to) make payment of the purchase price for the
Securities to be purchased by any Initial Purchaser whose funds have not been received by the
Closing Time, but such payment shall not relieve such Initial Purchaser from its obligations
hereunder.

     (c) Denominations; Registration. Certificates for the Securities shall be in such
denominations ($1,000 or integral multiples thereof) and registered in such names as the
Representative may request in writing at least one full business day before the Closing Time. The
certificates for the Securities will be made available for examination and packaging by the
Representative in The City of New York not later than 10:00 A.M. (Eastern time) on the business day
prior to the Closing Time.

     SECTION 3. Covenants of the Company. The Company covenants with each Initial
Purchaser as follows:

     (a) Offering Memorandum. The Company will promptly furnish to each Initial Purchaser, without
charge, such number of copies of the Offering Memorandum and any amendments and supplements thereto
and documents incorporated by reference therein as such Initial Purchaser may reasonably request.

     (b) Notice and Effect of Material Events. The Company will promptly notify each Initial
Purchaser, and, if requested by the Representative, confirm such notice in writing, of (x) any
filing made by the Company of information relating to the offering of the Securities with any
securities exchange or any other regulatory body in the United States or any other jurisdiction,
and (y) prior to the completion of the placement of the offered Securities by the Initial
Purchasers as evidenced by a notice in writing from the Initial Purchasers to the Company, any
material changes in or affecting the condition, financial or otherwise, or the earnings, business
affairs or business prospects of the Company and its subsidiaries considered as one enterprise
which (i) make any statement in the Offering Memorandum false or misleading or (ii) are not
disclosed in the Offering Memorandum. In such event or if during such time any event shall occur
as a result of which it is necessary, in the reasonable opinion of any of the Company, its counsel,
the Initial Purchasers or counsel for the Initial Purchasers, to amend or supplement the Offering
Memorandum in order that the Offering Memorandum not include any untrue statement of a material
fact or omit to state a material fact necessary in order to make the statements therein not
misleading in the light of the circumstances then existing, the Company will forthwith amend or
supplement the Offering Memorandum by preparing and furnishing to

9

 

each Initial Purchaser an amendment or amendments of, or a supplement or supplements to, the
Offering Memorandum (in form and substance satisfactory in the reasonable opinion of counsel for
the Initial Purchasers) so that, as so amended or supplemented, the Offering Memorandum will not
include an untrue statement of a material fact or omit to state a material fact necessary in order
to make the statements therein, in the light of the circumstances existing at the time it is
delivered to a Subsequent Purchaser, not misleading.

     (c) Amendment to Offering Memorandum and Supplements. The Company will advise each Initial
Purchaser promptly of any proposal to amend or supplement the Offering Memorandum and will not
effect such amendment or supplement without the consent of the Initial Purchasers. Neither the
consent of the Initial Purchasers, nor the Initial Purchasers’ delivery of any such amendment or
supplement, shall constitute a waiver of any of the conditions set forth in Section 5 hereof.

     (d) Qualification of Securities for Offer and Sale. The Company will use its reasonable best
efforts, in cooperation with the Initial Purchasers, to qualify the offered Securities for offering
and sale under the applicable securities laws of such states and other jurisdictions as the
Representative may designate and to maintain such qualifications in effect as long as required for
the sale of the Securities; provided, however, that the Company shall not be obligated to file any
general consent to service of process or to qualify as a foreign corporation or as a dealer in
securities in any jurisdiction in which it is not so qualified or to subject itself to taxation in
respect of doing business in any jurisdiction in which it is not otherwise so subject.

     (e) DTC. The Company will cooperate with the Initial Purchasers and use its reasonable best
efforts to permit the offered Securities to be eligible for clearance and settlement through the
facilities of DTC.

     (f) Use of Proceeds. The Company will use the net proceeds received by it from the sale of
the Securities in the manner specified in the Offering Memorandum under “Use of Proceeds.”

     (g) No Manipulation of Price. The Company will not take, directly or indirectly, any action
designed to cause or result in, or that has constituted or might reasonably be expected to
constitute, the stabilization or manipulation of the price of any securities of the Company in
violation of any applicable securities laws.

     (h) Listing. The Company will use its reasonable best efforts to have the Common Stock to be
issued upon conversion of the Securities approved by the NASDAQ, subject to notice of issuance,
prior to the effectiveness of the Registration Statement.

     (i) Reservation of Common Stock. The Company will reserve and keep available at all times,
free of preemptive or other similar rights, a sufficient number of authorized and unissued shares
of Common Stock for the purpose of enabling the Company to satisfy any obligations to issue Common
Stock upon the conversion of the Securities

     (j) Restriction on Sale of Securities. During a period of 45 days from the date of the
Offering Memorandum, the Company will not, without the prior written consent of Merrill Lynch and
Citigroup, directly or indirectly, (x) offer, pledge, sell, contract to sell, sell any option or
contract to purchase, purchase any option or contract to sell, grant any option, right or warrant
for the sale of, or lend or otherwise dispose of or transfer any of the Common Stock or any
securities convertible into or exercisable or exchangeable for or repayable with Common Stock,
whether

10

 

such securities are owned at the date of the Offering Memorandum or whether they are acquired
during the 45 day period after the date of the Offering Memorandum; (y) file a registration
statement for any Common Stock or any securities convertible into or exercisable or exchangeable
for or repayable with Common Stock; or (z) enter into any swap or any other agreement or any other
transaction that transfers, in whole or in part, the economic consequences of ownership of any
Common Stock or any securities convertible into or exercisable or exchangeable for or repayable
with Common Stock, whether any such swap or transaction above is to be settled by delivery of
Common Stock or such other securities, in cash or otherwise. The foregoing sentence shall not
apply to (A) the Securities to be sold hereunder or the Common Stock to be delivered upon
conversion thereof, (B) the resale registration statement to be filed by the Company pursuant to
the Registration Rights Agreement relating to the resale of the Securities and the shares of Common
Stock, (C) Common Stock to be issued pursuant to employee benefit plans, qualified stock option
plans or other employee compensation benefit plans or pursuant to currently outstanding options,
warrants or rights existing on the date hereof and referred to in the Offering Memorandum or (D) a
post-effective amendment to any currently effective resale registration statement to be filed by
the Company.

     (k) Trust Indenture Act. As of the date of the effectiveness of the Registration Statement
filed pursuant to the Registration Rights Agreement, the Company will cause the Indenture to be
qualified under the 1939 Act.

     (l) PORTAL Designation. The Company will use its reasonable best efforts to permit the
Securities to be designated PORTAL securities in accordance with the rules and regulations adopted
by the NASD relating to trading in the PORTAL Market.

     (m) Reporting Requirements. Until the offering of the Securities is complete, the Company
will file all documents required to be filed with the Commission pursuant to the Exchange Act
within the time periods required by the Exchange Act and the Exchange Act Regulations.

     SECTION 4. Payment of Expenses. (a) Expenses. The Company will pay all expenses
incident to the performance of its obligations under this Agreement, including (i) the preparation,
printing and delivery to the Initial Purchasers of the Offering Memorandum (including financial
statements and any schedules or exhibits and any documents incorporated therein by reference) as
originally filed and of each amendment or supplement thereto, (ii) the preparation, printing and
delivery to the Initial Purchasers of this Agreement, the Indenture, the Registration Rights
Agreement and such other documents as may be required in connection with the offering, purchase,
sale, issuance or delivery of the Securities or the issuance or delivery of the Common Stock
issuable upon conversion thereof, (iii) the preparation, issuance and delivery of the certificates
for the Securities to the Initial Purchasers and the certificates for the Common Stock issuable
upon conversion thereof, including any transfer taxes, any stamp or other duties payable upon the
sale, issuance and delivery of the Securities to the Initial Purchasers, the issuance and delivery
of the Common Stock issuable upon conversion thereof and any charges of DTC in connection
therewith, (iv) the fees and disbursements of the Company’s counsel, accountants and other
advisors, (v) the qualification of the Securities and the Common Stock under securities laws in
accordance with the provisions of Section 3(d) hereof, including filing fees and the reasonable
fees and disbursements of counsel for the Initial Purchasers in connection therewith and in
connection with the preparation of the Blue Sky Survey and any supplement thereto, (vi) the
printing and delivery to the Initial Purchasers of copies of each Preliminary Offering Memorandum
and any amendments or supplements thereto, (vii) the preparation, printing and delivery to the
Initial Purchasers of copies of the Blue Sky Survey and any

11

 

supplement thereto, (viii) the fees and expenses of the Trustee, including the fees and
disbursements of counsel for the Trustee in connection with the Indenture and the Securities, (ix)
the fees and expenses of any transfer agent or registrar for the Common Stock, (x) the costs and
expenses of the Company relating to investor presentations on any “road show” undertaken in
connection with the marketing of the Securities, including, without limitation, expenses associated
with the production of road show slides and graphics, fees and expenses of any consultants engaged
in connection with the road show presentations, and travel and lodging expenses of the
representatives and officers of the Company and any such consultants and (xi) any fees and expenses
payable in connection with the initial and continued designation of the Securities as PORTAL
securities under the PORTAL Market Rules pursuant to NASD Rule 5322.

     (a) Termination of Agreement. If this Agreement is terminated by the Representative prior to
the Closing Time in accordance with the provisions of Section 5 or Section 10(a)(i) hereof, the
Company shall reimburse the Initial Purchasers for all of their reasonable out-of-pocket expenses,
including the reasonable fees and disbursements of Shearman & Sterling LLP, counsel for the Initial
Purchasers.

     SECTION 5. Conditions of Initial Purchasers’ Obligations. The obligations of the
several Initial Purchasers hereunder are subject to the accuracy of the representations and
warranties of the Company contained in Section 1 hereof or in certificates of any officer of the
Company or any subsidiary of the Company delivered pursuant to the provisions hereof, to the
performance by the Company of its covenants and other obligations hereunder, and to the following
further conditions:

          (a) Opinions and Statements of Counsel for Company. At the Closing Time, the
Representative shall have received (i) from James H. Davis, Secretary and General Counsel
of the Company, an opinion letter, dated as of the Closing Time, to the effect set forth in
Exhibit A-1, and a statement, dated as of the Closing Time, to the effect set forth in the
last paragraph of Exhibit A-1 and (ii) from DLA Piper Rudnick Gray Cary US LLP, counsel
for the Company, an opinion letter, dated as of the Closing Time, to the effect set forth
in Exhibit A-2, and a statement, dated as of the Closing Time, to the effect set forth in
the last paragraph of Exhibit A-2. Such favorable opinions and statements shall be in form
and substance satisfactory in the reasonable judgment of counsel for the Initial Purchasers
and shall be delivered together with signed or reproduced copies of such opinions and
statements for each of the other Initial Purchasers. Such counsel may also state that,
insofar as any of such opinions involve factual matters, they have relied, to the extent
they deem proper, upon certificates of officers of the Company and its subsidiaries and
certificates of public officials.

          (b) Opinion of Counsel for Initial Purchasers. At Closing Time, the Initial
Purchasers shall have received the favorable opinion, dated as of Closing Time, of Shearman
& Sterling LLP, counsel for the Initial Purchasers. In giving such opinion, such counsel
may rely, as to all matters governed by the laws of jurisdictions other than the law of the
State of New York and the federal laws of the United States, upon the opinions of counsel
satisfactory to the Initial Purchasers. Such counsel may also state that, insofar as such
opinion involves factual matters, they have relied, to the extent they deem proper, upon
certificates of officers of the Company and its subsidiaries and certificates of public
officials.

12

 

          (c) Officers’ Certificate. At the Closing Time, there shall not have been, since the
date hereof or since the respective dates as of which information is given in the Final
Offering Memorandum (exclusive of any amendments or supplements thereto subsequent to the
date of this Agreement), any material adverse change in the condition, financial or
otherwise, or in the earnings, business affairs or business prospects of the Company and
its subsidiaries considered as one enterprise, whether or not arising in the ordinary
course of business, and the Initial Purchasers shall have received a certificate of the
Chief Executive Officer or President and of the Chief Financial Officer of the Company,
dated as of the Closing Time, to the effect that, to the best of their knowledge, after
reasonable investigation (i) there has been no such material adverse change, (ii) the
representations and warranties in Section 1 hereof are true and correct with the same force
and effect as though expressly made at and as of the Closing Time, and (iii) the Company
has complied with all agreements and satisfied all conditions on its part to be performed
or satisfied at or prior to the Closing Time.

          (d) Accountant’s Comfort Letter. At the time of the execution of this Agreement, the
Representative shall have received from Ernst & Young LLP a letter dated such date, in form
and substance satisfactory in the reasonable judgment of the Representative, together with
signed or reproduced copies of such letter for each of the other Initial Purchasers
containing statements and information of the type ordinarily included in accountants’
“comfort letters” to underwriters with respect to the financial statements and certain
financial information contained in the Offering Memorandum, except that the specified date
referred to shall be a date not more than three business days prior to the Closing Time.

          (e) Bring-down Comfort Letter. At the Closing Time, the Representative shall have
received from Ernst & Young LLP a letter, dated as of the Closing Time, to the effect that
they reaffirm the statements made in the letter furnished pursuant to subsection (d) of
this Section, except that the specified date referred to shall be a date not more than
three business days prior to the Closing Time.

          (f) PORTAL. At the Closing Time, the Securities shall have been designated for
trading on PORTAL.

          (g) Lock-up Agreements. At the date of this Agreement, the Representative shall have
received an agreement substantially in the form of Exhibit B hereto signed by the persons
listed on Schedule C hereto.

          (h) Indenture and Registration Rights Agreement. At or prior to the Closing Time, the
Company and the Trustee shall have executed and delivered the Indenture and the Company and
the Initial Purchaser shall have executed and delivered the Registration Rights Agreement.

          (i) Additional Documents. At the Closing Time, counsel for the Initial Purchasers
shall have been furnished with such documents, certificates and opinions as they may
reasonably require for the purpose of enabling them to pass upon the issuance and sale of
the Securities as herein contemplated, or in order to evidence the accuracy of any of the
representations or warranties, or the fulfillment of any of the conditions, herein
contained; and all proceedings taken by the Company in connection with the issuance and
sale of the Securities as herein contemplated shall be satisfactory in form and substance
in the reasonable judgment of the Representative and counsel for the Initial Purchasers.

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          (j) Termination of Agreement. If any condition specified in this Section shall not
have been fulfilled when and as required to be fulfilled by this Agreement, the obligations
of the several Initial Purchasers to purchase the Securities may be terminated by the
Representative by notice to the Company at any time at or prior to the Closing Time, and
such termination shall be without liability of any party to any other party except as
provided in Section 4 and except that Sections 1, 7, 8 and 9 shall survive any such
termination and remain in full force and effect until the applicable statute of limitations
has expired.

     SECTION 6. Subsequent Offers and Resales of the Securities.

     (a) Offer and Sale Procedures. Each of the Initial Purchasers and the Company hereby
establishes and agrees (and each Initial Purchaser agrees on behalf of any person acting on its
behalf) to observe the following procedures in connection with the offer and sale of the
Securities:

          (i) Offers and Sales. Offers and sales of the Securities shall be made within
the United States only to those persons the Initial Purchasers reasonably believe to be a
“qualified institutional buyer” within the meaning of Rule 144A under the 1933 Act (a
“Qualified Institutional Buyer”), and in such manner as is contemplated by the Offering
Memorandum.

          (ii) No General Solicitation. No general solicitation or general advertising
(within the meaning of Rule 502(c) under the 1933 Act) will be used in the United States in
connection with the offering or sale of the Securities.

          (iii) Purchases by Non-Bank Fiduciaries. In the case of a non-bank Subsequent
Purchaser of a Security acting as a fiduciary for one or more third parties, each third
party shall, in the judgment of the applicable Initial Purchaser, be a Qualified
Institutional Buyer.

          (iv) Subsequent Purchaser Notification. Each Initial Purchaser will take
reasonable steps to inform, and cause each of its U.S. Affiliates and others acting on its
behalf to take reasonable steps to inform, persons acquiring Securities from such Initial
Purchaser, Affiliate or such other person, as the case may be, in the United States that
the Securities (A) have not been and will not be registered under the 1933 Act, (B) are
being sold to them without registration under the 1933 Act in reliance on Rule 144A or in
accordance with another exemption from registration under the 1933 Act, as the case may be,
and (C) may not be offered, sold or otherwise transferred except (1) to the Company, (2)
inside the United States in accordance with (x) Rule 144A to a person whom the seller
reasonably believes is a Qualified Institutional Buyer that is purchasing such Securities
for its own account or for the account of a Qualified Institutional Buyer to whom notice is
given that the offer, sale or transfer is being made in reliance on Rule 144A or (y)
pursuant to another available exemption from registration under the 1933 Act.

          (v) Minimum Principal Amount. No sale of the Securities to any one Subsequent
Purchaser will be for less than U.S. $1,000 principal amount and no Security will be issued
in a smaller principal amount. If the Subsequent Purchaser is a non-bank fiduciary acting
on behalf of others, each person for whom it is acting must purchase at least U.S. $1,000
principal amount of the Securities.

14

 

          (vi) Restriction on Transfer. The transfer restrictions and the other
provisions set forth in the Offering Memorandum under the caption “Notice to Investors,”
including the legend required thereby, shall apply to the Securities except as otherwise
agreed by the Company and the Initial Purchasers. Following the sale of the Securities by
the Initial Purchasers to each Subsequent Purchaser pursuant to the terms hereof, the
Initial Purchasers shall not be liable or responsible to the Company for any losses,
damages or liabilities suffered or incurred by the Company, including any losses, damages
or liabilities under the 1933 Act, arising from or relating to any subsequent resale or
transfer of any Security.

     (b) Covenants of the Company. The Company covenants with each Initial Purchaser as follows:

          (i) Integration. The Company agrees that it will not and will cause its
Affiliates not to, directly or indirectly, solicit any offer to buy, sell or make any offer
or sale of, or otherwise negotiate in respect of, securities of the Company of any class
if, as a result of the doctrine of “integration” referred to in Rule 502 under the 1933
Act, such offer or sale would render invalid (for the purpose of (i) the sale of the
offered Securities by the Company to the Initial Purchasers, (ii) the resale of the offered
Securities by the Initial Purchasers to Subsequent Purchasers or (iii) the resale of the
offered Securities by such Subsequent Purchasers to others) the exemption from the
registration requirements of the 1933 Act provided by Section 4(2) thereof or by Rule 144A
thereunder or otherwise.

          (ii) Rule 144A Information. The Company agrees that, in order to render the
offered Securities eligible for resale pursuant to Rule 144A under the 1933 Act, while any
of the offered Securities remain outstanding, it will make available, upon request, to any
holder of offered Securities or prospective purchasers of Securities the information
specified in Rule 144A(d)(4), unless the Company furnishes information to the Commission
pursuant to Section 13 or 15(d) of the Exchange Act.

          (iii) Restriction on Repurchases. Until the expiration of two years after the
original issuance of the offered Securities, the Company will not, and will cause its
Affiliates not to, resell any offered Securities which are “restricted securities” (as such
term is defined under Rule 144(a)(3) under the 1933 Act), whether as beneficial owner or
otherwise (except as agent acting as a securities broker on behalf of and for the account
of customers in the ordinary course of business in unsolicited broker’s transactions).

     (c) Qualified Institutional Buyer. Each Initial Purchaser severally and not jointly
represents and warrants to, and agrees with, the Company that, as of the date hereof and as of the
Closing Time, it is a Qualified Institutional Buyer and an “accredited investor” within the meaning
of Rule 501(a) under the 1933 Act (an “Accredited Investor”).

     SECTION 7. Indemnification.

     (a) Indemnification of Initial Purchasers. The Company agrees to indemnify and hold harmless
each Initial Purchaser, its Affiliates, its selling agents and each person, if any, who controls
any Initial Purchaser within the meaning of Section 15 of the 1933 Act or Section 20 of the
Exchange Act as follows:

15

 

          (i) against any and all loss, liability, claim, damage and expense whatsoever, as
incurred, arising out of any untrue statement or alleged untrue statement of a material
fact contained in any Preliminary Offering Memorandum or the Final Offering Memorandum (or
any amendment or supplement thereto), or the omission or alleged omission therefrom of a
material fact necessary in order to make the statements therein, in the light of the
circumstances under which they were made, not misleading;

          (ii) against any and all loss, liability, claim, damage and expense whatsoever, as
incurred, to the extent of the aggregate amount paid in settlement of any litigation, or
any investigation or proceeding by any governmental agency or body, commenced or
threatened, or of any claim whatsoever based upon any such untrue statement or omission of
a material fact, or any such alleged untrue statement or omission of a material fact;
provided that (subject to Section 7(d) below) any such settlement is effected with the
written consent of the Company; and

          (iii) against any and all expense whatsoever, as incurred (including the fees and
disbursements of counsel chosen by Merrill Lynch), reasonably incurred in investigating,
preparing or defending against any litigation, or any investigation or proceeding by any
governmental agency or body, commenced or threatened, or any claim whatsoever based upon
any such untrue statement or omission of a material fact, or any such alleged untrue
statement or omission of a material fact, to the extent that any such expense is not paid
under (i) or (ii) above;

provided, however, that this indemnity agreement shall not apply to any loss, liability, claim,
damage or expense to the extent arising out of any untrue statement or omission of a material fact
or alleged untrue statement or omission of a material fact made in reliance upon and in conformity
with written information furnished to the Company by any Initial Purchaser through Merrill Lynch
expressly for use in the Offering Memorandum (or any amendment thereto).

     (b) Indemnification of Company. Each Initial Purchaser severally agrees to indemnify and hold
harmless the Company and each person, if any, who controls the Company within the meaning of
Section 15 of the 1933 Act or Section 20 of the Exchange Act against any and all loss, liability,
claim, damage and expense described in the indemnity contained in subsection (a) of this Section,
as incurred, but only with respect to untrue statements or omissions of a material fact, or alleged
untrue statements or omissions of a material fact, made in the Offering Memorandum in reliance upon
and in conformity with written information furnished to the Company by such Initial Purchaser
through Merrill Lynch expressly for use in the Offering Memorandum.

     (c) Actions Against Parties; Notification. Each indemnified party shall give notice as
promptly as reasonably practicable to each indemnifying party of any action commenced against it in
respect of which indemnity may be sought hereunder, but failure to so notify an indemnifying party
shall not relieve such indemnifying party from any liability hereunder to the extent it is not
materially prejudiced as a result thereof and in any event shall not relieve it from any liability
which it may have otherwise than on account of this indemnity agreement. In the case of parties
indemnified pursuant to Section 7(a) above, counsel to the indemnified parties shall be selected by
Merrill Lynch, and, in the case of parties indemnified pursuant to Section 7(b) above, counsel to
the indemnified parties shall be selected by the Company. An indemnifying party may participate at
its own expense in the defense of any such action; provided, however, that counsel to the
indemnifying party shall not (except with the consent of the indemnified party) also be counsel to
the indemnified party. In no event shall the

16

 

indemnifying parties be liable for fees and expenses of more than one counsel (in addition to
any local counsel) separate from their own counsel for all indemnified parties in connection with
any one action or separate but similar or related actions in the same jurisdiction arising out of
the same general allegations or circumstances. No indemnifying party shall, without the prior
written consent of the indemnified parties, settle or compromise or consent to the entry of any
judgment with respect to any litigation, or any investigation or proceeding by any governmental
agency or body, commenced or threatened, or any claim whatsoever in respect of which
indemnification or contribution could be sought under this Section or Section 8 hereof (whether or
not the indemnified parties are actual or potential parties thereto), unless such settlement,
compromise or consent (i) includes an unconditional release of each indemnified party from all
liability arising out of such litigation, investigation, proceeding or claim and (ii) does not
include a statement as to or an admission of fault, culpability or a failure to act by or on behalf
of any indemnified party.

     (d) Settlement Without Consent if Failure to Reimburse. If at any time an indemnified party
shall have requested an indemnifying party to reimburse the indemnified party for fees and expenses
of counsel, such indemnifying party agrees that it shall be liable for any settlement of the nature
contemplated by Section 7(a)(ii) effected without its written consent if (i) such settlement is
entered into more than 45 days after receipt by such indemnifying party of the aforesaid request,
(ii) such indemnifying party shall have received notice of the terms of such settlement at least 30
days prior to such settlement being entered into and (iii) such indemnifying party shall not have
reimbursed such indemnified party in accordance with such request prior to the date of such
settlement.

     SECTION 8. Contribution. If the indemnification provided for in Section 7 hereof is
for any reason unavailable to or insufficient to hold harmless an indemnified party in respect of
any losses, liabilities, claims, damages or expenses referred to therein, then each indemnifying
party shall contribute to the aggregate amount of such losses, liabilities, claims, damages and
expenses incurred by such indemnified party, as incurred, (i) in such proportion as is appropriate
to reflect the relative benefits received by the Company on the one hand and the Initial Purchasers
on the other hand from the offering of the Securities pursuant to this Agreement or (ii) if the
allocation provided by clause (i) is not permitted by applicable law, in such proportion as is
appropriate to reflect not only the relative benefits referred to in clause (i) above but also the
relative fault of the Company on the one hand and of the Initial Purchasers on the other hand in
connection with the statements or omissions which resulted in such losses, liabilities, claims,
damages or expenses, as well as any other relevant equitable considerations.

     The relative benefits received by the Company on the one hand and the Initial Purchasers on
the other hand in connection with the offering of the Securities pursuant to this Agreement shall
be deemed to be in the same respective proportions as the total net proceeds from the offering of
the Securities pursuant to this Agreement (before deducting expenses) received by the Company and
the total underwriting discount received by the Initial Purchasers bear to the aggregate initial
offering price of the Securities.

     The relative fault of the Company on the one hand and the Initial Purchasers on the other hand
shall be determined by reference to, among other things, whether any such untrue or alleged untrue
statement of a material fact or omission or alleged omission to state a material fact relates to
information supplied by the Company or by the Initial Purchasers and the parties’ relative intent,
knowledge, access to information and opportunity to correct or prevent such statement or omission.

17

 

     The Company and the Initial Purchasers agree that it would not be just and equitable if
contribution pursuant to this Section were determined by pro rata allocation (even if the Initial
Purchasers were treated as one entity for such purpose) or by any other method of allocation which
does not take account of the equitable considerations referred to above in this Section. The
aggregate amount of losses, liabilities, claims, damages and expenses incurred by an indemnified
party and referred to above in this Section shall be deemed to include any legal or other expenses
reasonably incurred by such indemnified party in investigating, preparing or defending against any
litigation, or any investigation or proceeding by any governmental agency or body, commenced or
threatened, or any claim whatsoever based upon any such untrue or alleged untrue statement or
omission or alleged omission.

     Notwithstanding the provisions of this Section, no Initial Purchaser shall be required to
contribute any amount in excess of the amount by which the total price at which the Securities
purchased and sold by it hereunder exceeds the amount of any damages which such Initial Purchaser
has otherwise been required to pay by reason of such untrue or alleged untrue statement or omission
or alleged omission.

     No person guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the
1933 Act) shall be entitled to contribution from any person who was not guilty of such fraudulent
misrepresentation.

     For purposes of this Section, each person, if any, who controls an Initial Purchaser within
the meaning of Section 15 of the 1933 Act or Section 20 of the Exchange Act and each Initial
Purchaser’s Affiliates and selling agents shall have the same rights to contribution as such
Initial Purchaser, and the Company and each person, if any, who controls the Company within the
meaning of Section 15 of the 1933 Act or Section 20 of the Exchange Act shall have the same rights
to contribution as the Company. The Initial Purchasers’ respective obligations to contribute
pursuant to this Section are several in proportion to the principal amount of Securities set forth
opposite their respective names in Schedule A hereto and not joint.

     SECTION 9. Representations, Warranties and Agreements to Survive. All
representations, warranties and agreements contained in this Agreement or in certificates of
officers of the Company or any of its subsidiaries submitted pursuant hereto shall remain operative
and in full force and effect regardless of (i) any investigation made by or on behalf of any
Initial Purchaser or its Affiliates or selling agents, any person controlling any Initial
Purchaser, its officers or directors or any person controlling the Company and (ii) delivery of and
payment for the Securities.

     SECTION 10. Termination of Agreement.

     (a) Termination; General. The Representative may terminate this Agreement, by written notice
to the Company, at any time at or prior to the Closing Time (i) if there has been, since the time
of execution of this Agreement or since the respective dates as of which information is given in
the Offering Memorandum, any material adverse change in the condition, financial or otherwise, or
in the earnings, business affairs or business prospects of the Company and its subsidiaries
considered as one enterprise, whether or not arising in the ordinary course of business, or (ii) if
there has occurred any material adverse change in the financial markets in the United States or the
international financial markets, any outbreak of hostilities or escalation thereof or other
calamity or crisis or any change or development involving a prospective change in national or
international political, financial or economic conditions, in each case the effect of which is such
as to make it, in the judgment of the Representative, impracticable or inadvisable to market the
Securities or to enforce contracts for the sale of the Securities, or (iii) if trading in any

18

 

securities of the Company has been suspended or materially limited by the Commission or the
Nasdaq National Market, or if trading generally on the American Stock Exchange or the New York
Stock Exchange or in the Nasdaq National Market has been suspended or materially limited, or
minimum or maximum prices for trading have been fixed, or maximum ranges for prices have been
required, by any of said exchanges or by such system or by order of the Commission, the National
Association of Securities Dealers, Inc. or any other governmental authority, or (iv) a material
disruption has occurred in commercial banking or securities settlement or clearance services in the
United States, or (v) if a banking moratorium has been declared by either Federal or New York
authorities.

     (b) Liabilities. If this Agreement is terminated pursuant to this Section, such termination
shall be without liability of any party to any other party except as provided in Section 4 hereof,
and provided further that Sections 1, 7, 8 and 9 shall survive such termination and remain in full
force and effect until the applicable statute of limitations has expired.

     SECTION 11. Default by One or More of the Initial Purchasers. If one or more of the
Initial Purchasers shall fail at the Closing Time to purchase the Securities which it or they are
obligated to purchase under this Agreement (the “Defaulted Securities”), the Representative shall
have the right, within 24 hours thereafter, to make arrangements for one or more of the
non-defaulting Initial Purchasers, or any other initial purchasers, to purchase all, but not less
than all, of the Defaulted Securities in such amounts as may be agreed upon and upon the terms
herein set forth. If, however, the Representative shall not have completed such arrangements
within such 24-hour period, then:

          (i) if the number of Defaulted Securities does not exceed 10% of the aggregate
principal amount of the Securities to be purchased hereunder, each of the non-defaulting
Initial Purchasers shall be obligated, severally and not jointly, to purchase the full
amount thereof in the proportions that their respective underwriting obligations hereunder
bear to the underwriting obligations of all non-defaulting Initial Purchasers; or

          (ii) if the number of Defaulted Securities exceeds 10% of the aggregate principal
amount of the Securities to be purchased on such date, this Agreement shall terminate
without liability on the part of the Company or any non-defaulting Initial Purchaser.

     No action taken pursuant to this Section shall relieve any defaulting Initial Purchaser from
liability in respect of its default.

     In the event of any such default which does not result in a termination of this Agreement,
either the Representative or the Company shall have the right to postpone the Closing Time, for a
period not exceeding seven days in order to effect any required changes in the Offering Memorandum
or in any other documents or arrangements. As used herein, the term “Initial Purchaser” includes
any person substituted for an Initial Purchaser under this Section 11.

     SECTION 12. No Fiduciary Relationship. The Company acknowledges and agrees that (i)
the purchase and sale of the Securities pursuant to this Agreement, including the determination of
the public offering price of the Securities and any related discounts and commissions, is an
arm’s-length commercial transaction between the Company, on the one hand, and the several Initial
Purchasers, on the other hand, (ii) in connection with the offering contemplated hereby and the
process leading to such transaction each Initial Purchaser is and has been acting solely as a
principal and is not the agent or fiduciary of the Company, or its stockholders, creditors,

19

 

employees or any other party, (iii) no Initial Purchaser has assumed or will assume an
advisory or fiduciary responsibility in favor of the Company with respect to the offering
contemplated hereby or the process leading thereto (irrespective of whether such Initial Purchaser
has advised or is currently advising the Company on other matters) and no Initial Purchaser has any
obligation to the Company with respect to the offering contemplated hereby except the obligations
expressly set forth in this Agreement, (iv) the Initial Purchasers and their respective Affiliates
may be engaged in a broad range of transactions that involve interests that differ from those of
the Company, and (v) the Initial Purchasers have not provided any legal, accounting, regulatory or
tax advice with respect to the offering contemplated hereby and the Company has consulted its own
legal, accounting, regulatory and tax advisors to the extent it deemed appropriate.

     SECTION 13. Notices. All notices and other communications hereunder shall be in
writing and shall be deemed to have been duly given if mailed or transmitted by any standard form
of telecommunication. Notices to the Initial Purchasers shall be directed to the Representative at
4 World Financial Center, New York, New York 10080, attention of Anthony Gibney ; and
notices to the Company shall be directed to it at Human Genome Sciences, Inc., 14200 Shady Grove
Road, Rockville, Maryland 20850, attention of James H. Davis, Secretary and General Counsel.

     SECTION 14. Parties. This Agreement shall each inure to the benefit of and be binding
upon the Initial Purchasers and the Company and their respective successors. Nothing expressed or
mentioned in this Agreement is intended or shall be construed to give any person, firm or
corporation, other than the Initial Purchasers and the Company and their respective successors and
the controlling persons and officers and directors referred to in Sections 7 and 8 and their heirs
and legal representatives, any legal or equitable right, remedy or claim under or in respect of
this Agreement or any provision herein contained. This Agreement and all conditions and provisions
hereof are intended to be for the sole and exclusive benefit of the Initial Purchasers and the
Company and their respective successors, and said controlling persons and officers and directors
and their heirs and legal representatives, and for the benefit of no other person, firm or
corporation. No purchaser of Securities from any Initial Purchaser shall be deemed to be a
successor by reason merely of such purchase.

     SECTION 15. GOVERNING LAW. THIS AGREEMENT SHALL BE GOVERNED BY AND CONSTRUED IN
ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK. 

     SECTION 16. TIME. TIME SHALL BE OF THE ESSENCE OF THIS AGREEMENT. EXCEPT AS
OTHERWISE SET FORTH HEREIN, SPECIFIED TIMES OF DAY REFER TO NEW YORK CITY TIME.

     SECTION 17. Counterparts. This Agreement may be executed in any number of
counterparts, each of which shall be deemed to be an original, but all such counterparts shall
together constitute one and the same Agreement. 

     SECTION 18. Effect of Headings. The Section headings herein are for convenience only
and shall not affect the construction hereof.

     SECTION 19. Partial Unenforceability. The invalidity or unenforceability of any
Section, paragraph or provision of this Agreement shall not affect the validity or enforceability
of any other Section, paragraph or provision hereof. If any Section, paragraph or provision of
this Agreement is for any reason determined to be invalid or unenforceable, there shall be deemed
to

20

 

be made such minor changes (and only such minor changes) as are necessary to make it valid and
enforceable.

21

 

     If the foregoing is in accordance with your understanding of our agreement, please sign and
return to the Company a counterpart hereof, whereupon this instrument, along with all counterparts,
will become a binding agreement between the Initial Purchasers and the Company in accordance with
its terms.

	 	 	 	 	 
	 	 	Very truly yours,
	 
	 	 	 	 
	 	 	HUMAN GENOME SCIENCES, INC.
	 
	 	 	 	 
	 

	 	By
	 	/s/ Steven C. Mayer
	 	 	 	 	 
	 

	 	 	 	Title: Executive Vice President and CFO

	 	 	 	 	 
	CONFIRMED AND ACCEPTED,	 	 
	 

	 	as of the date first above written:	 	 
	 
	 	 	 	 
	MERRILL LYNCH, PIERCE, FENNER & SMITH INCORPORATED	 	 
	 
	 	 	 	 
	By

	 	   /s/ Anthony J. Gibney	 	 
	 	 	 	 	 
	 

	 	           Authorized Signatory	 	 
	 
	 	 	 	 
	CITIGROUP GLOBAL MARKETS INC.	 	 
	 
	 	 	 	 
	By

	 	    /s/ Trygve Mikkelesen	 	 
	 	 	 	 	 
	 

	 	           Authorized Signatory	 	 

22

 

SCHEDULE A

	 	 	 	 	 
	 	 	Principal
	 	 	Amount of
	Name of Initial Purchaser 	 	Securities
	Merrill Lynch, Pierce, Fenner & Smith
	 	 	 	 
	Incorporated
	 	$	115,000,000	 
	Citigroup Global Markets Inc
	 	$	115,000,000	 
	 
	 	 	 	 
	 
	 	 	 	 
	Total
	 	$	230,000,000	 
	 
	 	 	 	 

 

 

SCHEDULE B

HUMAN GENOME SCIENCES, INC.

$230,000,000 Convertible Subordinated Notes due 2012

     1. The initial public offering price of the Securities shall be 98.5% of the principal amount
thereof, plus accrued interest, if any, from the date of issuance.

     2. The purchase price to be paid by the Initial Purchasers for the Securities shall be 97.125%
of the principal amount thereof.

     3. The interest rate on the Securities shall be 21/4% per annum.

     4. The Securities shall be convertible into shares of common stock, par value $0.01 per share,
of the Company at an initial conversion rate of 56.2303 shares per $1,000 principal amount of
Securities (equivalent to a conversion price of approximately $17.78 per share).

 

 

SCHEDULE C

SCHEDULE OF OFFICERS SUBJECT TO LOCK-UP ARRANGEMENTS

H. Thomas Watkins

Craig A. Rosen

James H. Davis

Steven C. Mayer

David C. Stump

Susan Bateson McKay

 

 

Exhibit A-1

FORM OF OPINION OF COMPANY’S GENERAL COUNSEL

TO BE DELIVERED PURSUANT TO

SECTION 5(a)

	1.	 	The outstanding shares of common stock of the Company, par value $.01 per share, have been
duly authorized and validly issued, are fully paid and nonassessable and conform to the
description thereof contained in the Offering Memorandum.
	 
	2.	 	To the best of my knowledge, the Company has not received any notice (written or oral) of
infringement of or declared interference with the asserted rights of any other person with
respect to any intellectual property rights that, if determined adversely to the Company,
would individually or in the aggregate have a Material Adverse Effect on the Company.
	 
	3.	 	Excluding the matters contained under the caption “U.S. Federal Tax Considerations,” the
descriptions in the Offering Memorandum and the Exchange Act Reports incorporated therein of
statutes (excluding Federal and state securities laws), legal and governmental proceedings and
contracts relevant to the Company and its business in all material respects are accurate
statements or summaries of the matters set forth therein.
	 
	4.	 	The execution, delivery and performance of the Indenture, the Registration Rights Agreement
and the Purchase Agreement and the issuance and sale of the Securities in accordance with the
terms of the Purchase Agreement and the Indenture and compliance with the terms and provisions
thereof by the Company will not result in a breach or violation of any of the terms and
provisions of, or constitute a default under (i) to my knowledge, any statute, rule,
regulation or order of any governmental agency or body or any court having jurisdiction over
the Company or any of its properties, (ii) to my knowledge, any agreement or instrument to
which the Company is a party or by which the Company is bound or to which any of the
properties of the Company is subject or (iii) the Certificate of Incorporation or By-Laws of
the Company.
	 
	5.	 	To the best of my knowledge, no holders of securities of the Company have rights to the
registration of such securities under the Certificate of Incorporation of the Company or
pursuant to the terms of any agreement to which the Company is a party.
	 
	6.	 	There is no action, suit or proceeding pending before or, to the best of my knowledge,
threatened or contemplated by any court or public or governmental authority or arbitrator
involving the Company of a character required to be disclosed in the Offering Memorandum which
is not adequately disclosed or incorporated by reference in the Offering Memorandum.
	 
	7.	 	Two U.S. patents owned, assigned or licensed to the Company and three non-U.S. patents owned,
assigned or licensed to the Company claim the composition, use or manufacture of Lymphostat-B;
one U.S. patent owned, assigned or licensed to the Company and no non-U.S. patents owned,
assigned or licensed to the Company claim the composition, use or manufacture of HGS-ETR1; one
U.S. patent owned, assigned or licensed to the Company and three non-U.S. patents owned,
assigned or licensed to the Company claim the composition, use or manufacture of HGS-ETR2; one
U.S. patent owned, assigned or licensed to the Company and three non-U.S. patents owned,
assigned or licensed to the Company claim the composition, use or manufacture of HGS-TR2J; no
U.S. patents

 

 

	 	 	owned, assigned or licensed to the Company and one non-U.S. patent (i.e., one Europe patent
validated in 17 countries) owned, assigned or licensed to the Company claim the composition,
use or manufacture of Albuferon; two U.S. patents owned, assigned or licensed to the Company
and no non-U.S. patents owned, assigned or licensed to the Company claim the composition, use
or manufacture of CCR5 antibody; all such patents are being duly maintained by the Company or
its licensors and are in full force and effect. In addition, there are numerous other patent
applications that claim the composition, use or manufacture of these products and they are
being diligently prosecuted by the Company or its licensors.
	 
	8.	 	Except as disclosed in the Offering Memorandum, the Company and its subsidiaries own or
possess, or can acquire on reasonable terms, patents, inventions, copyrights, know-how
(including trade secrets and other unpatented and/or unpatentable proprietary or confidential
information, systems or procedures), trademarks, service marks, trade names or other
intellectual property (collectively, “Intellectual Property”) necessary to carry on the
business as described in the Offering Memorandum. Except as disclosed in the Offering
Memorandum, neither the Company nor any of its subsidiaries has received any notice of any
claim by a third party against them alleging infringement of, interference with, or any other
conflict with asserted rights of others with respect to any Intellectual Property, which (if
the subject of any unfavorable decision, ruling or finding), singly or in the aggregate, would
result in a Material Adverse Effect.
	 
	9.	 	All the licenses to which the Company is a party listed in Schedule A hereto are in full
force and in effect, no party thereto is in breach or default thereof, and the Company is not
engaged in any activity that would be prohibited under the terms of the licenses.
	 
	 	 	Based upon my participation in conferences with certain executive officers of the Company and
representatives of its independent public accountants and my examination of the Offering
Memorandum and the documents incorporated by reference therein, I can state that (except as
to financial statements, schedules or other financial information included or incorporated by
reference therein, as to which I express no belief) nothing has come to my attention which
leads me to believe that the Offering Memorandum, or any amendment or supplement thereto, or
any Exchange Act Report or document incorporated by reference therein contained as of the
date thereof or, contains as of the date hereof any untrue statement of a material fact or
omitted on the date thereof or, omits to state any material fact required to be stated
therein or necessary to make the statements therein, in light of the circumstances in which
they were made, not misleading.

 

 

SCHEDULE A TO COMPANY COUNSEL OPINION

	I.	 	Human Consortium Agreements
	 
	1.	 	License Agreement dated June 28, 1996 between SmithKlineBeecham Corporation, now
GlaxoSmithKline Corporation, and Human Genome Sciences, Inc.
	 
	2.	 	Diagnostic Agreement dated July 24, 1997 between SmithKlineBeecham Corporation, now
GlaxoSmithKline Corporation, and Human Genome Sciences, Inc.
	 
	3.	 	Option and License Agreement dated June 12, 1995 between Takeda Chemical Industries, Ltd. and
Human Genome Sciences, Inc.
	 
	4.	 	Therapeutic Collaboration and License Agreement dated June 28, 1996 between Schering
Corporation, Schering-Plough Ltd., SmithKlineBeecham Corporation, now GlaxoSmithKline
Corporation, and Human Genome Sciences, Inc.
	 
	5.	 	Gene Therapy Collaboration and License Agreement dated June 28, 1996 between Schering
Corporation, Schering-Plough Ltd. and Human Genome Sciences, Inc.
	 
	6.	 	Collaboration and License Agreement dated June 30, 1996 between SmithKlineBeecham
Corporation, now GlaxoSmithKline Corporation, Human Genome Sciences, Inc. and
Sanofi-Synthelabo S.A.
	 
	7.	 	Collaboration and License Agreement dated July 10, 1996 between Merck KgaA, SmithKlineBeecham
Corporation, now GlaxoSmithKline Corporation, and Human Genome Sciences, Inc.
	 
	II.	 	Agreements Related to Product Development
	 
	1.	 	Amended and Restated License Agreement dated September 8, 2000 between Aventis Behring,
Aventis Behring GmbH, Aventis Bio-Services Inc., Delta Biotechnology Ltd. and Human Genome
Sciences, Inc.
	 
	 	 	Amendment dated August 10, 2001

Amendment dated October 3, 2001

Amendment dated April 19, 2002
	 
	2.	 	Amended and Restated Antibody Collaboration, Option and License Agreement dated July 18, 2001
between Abgenix, Inc. and Human Genome Sciences, Inc.
	 
	3.	 	Collaboration Agreement dated August 9, 1999 between Cambridge Antibody Technology Ltd. and
Human Genome Sciences, Inc.
	 
	4.	 	Antibody License Agreement dated February 29, 2000 between Cambridge Antibody Technology Ltd.
and Human Genome Sciences, Inc.
	 
	5.	 	License Agreement dated October 10, 2003 between diaDexus, Inc. and Human Genome Sciences,
Inc.

 

 

	6.	 	BioProcessing Services Agreement dated June 3, 2004 between Diosynth RTP Inc. and Human
Genome Sciences, Inc.
	 
	 	 	Amendment dated September 9, 2004

Amendment dated February 23, 2005

Amendment dated March 3, 2005
	 
	7.	 	Collaboration and License Agreement dated July 31, 2000 between The Dow Chemical Company and
Human Genome Sciences, Inc.
	 
	 	 	Amendment dated January 31, 2002
	 
	8.	 	Collaboration and License Agreement dated March 17, 2000 between Dyax Corp and Human Genome
Sciences, Inc.
	 
	 	 	Amendment dated July 1, 2001
	 
	9.	 	Antibody License Agreement dated October 28, 2002 between Kirin Brewery Company Ltd. and
Human Genome Sciences, Inc.
	 
	10.	 	Amended and Restated Research and Commercialization Agreement dated May 6, 2002 between
Medarex, Inc. and Human Genome Sciences Inc.
	 
	11.	 	Amended and Restated License Agreement dated February 28, 2001 between Corautus (Vascular
Genetics) and Human Genome Sciences, Inc.
	 
	 	 	Amendment dated October 10, 2002

Amendment dated April 26, 2004
	 
	12.	 	Gene Therapy Collaboration and License Agreement dated February 25, 1998 between Transgene
S.A. and Human Genome Sciences, Inc.
	 
	13.	 	License Agreement dated February 24, 2000 between Vical Incorporated and Human Genome
Sciences, Inc.
	 
	14.	 	Collaboration and License Agreement effective July 27, 1995 between Medimmune, Inc. and Human
Genome Sciences, Inc.
	 
	 	 	Amendment Agreements effective October 22, 1996, March 20, 1997, December 18, 1997, June
30, 2000 and August 6, 2004
	 
	15.	 	License and Research Agreement dated October 2 1996 between Pharmacia & Upjohn Company and
Human Genome Sciences, Inc.
	 
	 	 	Amendment Letter from Pfizer Inc. dated December 8, 2003
	 
	16.	 	License Agreement dated August 4, 2003 between Genentech Inc. and Human Genome Sciences, Inc.
	 
	17.	 	Research Collaboration Agreement dated January 1996 between Pioneer Hi-Bred International,
Inc. and Human Genome Sciences, Inc.

 

 

	18.	 	License Agreement (Streptococcus pneumoniae) dated March 20, 1996 between Hoffman-La Roche,
Inc. and Human Genome Sciences, Inc.
	 
	19.	 	License Agreement (Enterococcus faecalis) dated June 30, 1997 between Hoffman-La Roche, Inc.
and Human Genome Sciences, Inc.
	 
	20.	 	License Agreement (Staphylococcus aureus) dated March 23, 1998 between Hoffmann-La Roche,
Inc. and Human Genome Sciences, Inc.
	 
	21.	 	Exclusive License Agreement dated October 5, 2004 between SmithKline Beecham Corporation
doing business as GlaxoSmithKline and Human Genome Sciences, Inc.
	 
	22.	 	License Agreement dated December 21, 2002 between Lonza Biologics PLC and Human Genome
Sciences, Inc.
	 
	23.	 	Multi-Product License Agreement dated September 13, 2004 between Lonza Biologics PLC and
Human Genome Sciences, Inc.
	 
	24.	 	License Agreement (ETR1) dated November 14, 2003 between The Regents of the University of
Michigan and Human Genome Sciences, Inc.

 

 

Exhibit A-2

FORM OF OPINION OF DLA PIPER RUDNICK GRAY CARY US LLP

TO BE DELIVERED PURSUANT TO

SECTION 5(a)

	1.	 	The Company has been duly incorporated and is an existing corporation in good standing under
the laws of the State of Delaware, with corporate power and authority to own its properties
and conduct its business as described in the Offering Memorandum and the Exchange Act Reports.
The Company is duly qualified to do business as a foreign corporation in good standing in all
other jurisdictions in which its ownership or lease of property or the conduct of its business
requires such qualification, except where the failure to so qualify would not have a Material
Adverse Effect on the Company.
	 
	2.	 	The Indenture and the Registration Rights Agreement have been duly authorized, executed and
delivered by the Company and conform in all material respects to the descriptions thereof
contained in the Offering Memorandum. The Securities have been duly authorized, executed,
issued and delivered by the Company and conform in all material respects to the description
thereof contained in the Offering Memorandum. The Indenture, the Registration Rights
Agreement and the Securities constitute valid and legally binding obligations of the Company
enforceable against the Company in accordance with their terms, subject to bankruptcy,
insolvency, fraudulent transfer, reorganization, moratorium and similar laws of general
applicability relating to or affecting creditors’ rights and to general equity principles
including public policy limitations with respect to the enforceability of the indemnification
provisions of the Registration Rights Agreement.
	 
	3.	 	The Securities are convertible into Common Stock of the Company in accordance with the terms
of the Indenture. The shares of such Common Stock initially issuable upon conversion of the
Securities have been duly authorized and reserved for issuance upon such conversion and, when
issued upon such conversion, will be validly issued, fully paid and nonassessable. The
stockholders of the Company have no preemptive rights with respect to the Securities or the
Common Stock to be issued upon conversion thereof under the Certificate of Incorporation,
By-Laws or the Delaware General Corporation Law, or to the best of our knowledge, under any
other document or agreement to which the Company is a party.
	 
	4.	 	The Company is not and, after giving effect to the offering and sale of the Securities and
the application of the proceeds thereof as described in the Offering Memorandum, will not be
an “investment company” as defined in the Investment Company Act of 1940.
	 
	5.	 	No consent, approval, authorization or order of, or filing with, any governmental agency or
body or any court is required for the consummation of the transactions contemplated by the
Purchase Agreement in connection with the issuance or sale of the Securities by the Company,
the issuance and delivery of the shares of Common Stock issuable upon conversion of the
Securities (assuming such conversion on the date hereof) or the consummation by the Company of
the transactions contemplated by the Purchase Agreement, the Indenture or the Registration
Rights Agreement, except (i) such as may be required under state securities laws and (ii) with
respect to the Registration Rights

 

 

	 	 	Agreement only, filings and other actions required pursuant to the Securities Act, the
Exchange Act, the Trust Indenture Act, and the rules and regulations of the Commission
promulgated thereunder.
	 
	6.	 	The execution, delivery and performance by the Company of the Indenture, the Registration
Rights Agreement and the Purchase Agreement and the issuance and sale of the Securities in
accordance with the terms of the Purchase Agreement and the Indenture and compliance with the
terms and provisions thereof by the Company will not result in a breach or violation of any of
the terms and provisions of, or constitute a default under, (i) any statute, rule, regulation
or order of any governmental agency or body or any court having jurisdiction over the Company
or any of its properties, (ii) to the best of our knowledge, any agreement or instrument to
which the Company is a party or by which the Company is bound or to which any of the
properties of the Company is subject, or (iii) the Certificate of Incorporation or By-Laws.
	 
	7.	 	The Company has all requisite corporate power and authority to execute and deliver the
Purchase Agreement and to perform its obligations thereunder. The execution, delivery and
performance by the Company of the Purchase Agreement and the consummation by the Company of
the transactions contemplated thereby have been duly authorized by all necessary corporate
action on the part of the Company. The Purchase Agreement has been duly authorized, executed
and delivered by the Company.
	 
	8.	 	It is not necessary in connection with (i) the offer, sale and delivery of the Securities by
the Company to the Initial Purchaser pursuant to the Purchase Agreement, or (ii) the resales
of the Securities by the Initial Purchaser, in each case in the manner contemplated by the
Purchase Agreement, to register the Securities under the Securities Act or to qualify an
indenture in respect thereof under the Trust Indenture Act.
	 
	9.	 	To the best of our knowledge no holders of securities of the Company have rights to the
registration of such securities under the Certificate of Incorporation of the Company or
pursuant to the terms of any agreement to which the Company is a party.
	 
	10.	 	The statements in the Offering Memorandum under the caption “Description of Notes,” insofar
as they describe the provisions of the documents and instruments therein described, constitute
fair summaries thereof accurate in all material respects, and the statements in the Offering
Memorandum under the caption “U.S. Federal Tax Considerations,” insofar as they purport to
describe Federal income tax laws of the United States, fairly present in all material respects
the information set forth therein.
	 
	11.	 	There is no action, suit or proceeding pending before or, to the best of our knowledge,
threatened or contemplated by any court or public or governmental authority or arbitrator
involving the Company of a character required to be disclosed in the Offering Memorandum which
is not adequately disclosed or incorporated by reference in the Offering Memorandum.
	 
	12.	 	Each U.S. subsidiary of the Company has been duly organized and is validly existing as a
corporation or other entity in good standing under the laws of the jurisdiction of its
incorporation or organization, has corporate or other power and authority to own, lease and
operate its properties and to conduct its business as described in the Offering Memorandum and
is duly qualified as a foreign corporation or other entity to transact business and is in good
standing in each jurisdiction in which such qualification is

 

 

	 	 	required, whether by reason of the ownership or leasing of property or the conduct of
business.
	 
	13.	 	The documents incorporated by reference in the Offering Memorandum (other than the financial
statements and supporting schedules therein, as to which we express no opinion), when they
were filed with the Commission complied as to form in all material respects with the
requirements of the Exchange Act and the Exchange Act Regulations.
	 
	 	 	Based upon our review of the Offering Memorandum, the documents incorporated therein, and
our discussions with responsible officers of the Company and responsible representatives of
its independent public accountants, we can state that (except as to financial statements,
schedules or other financial information included or incorporated by reference therein, as
to which we express no belief) in the course of such review and discussion nothing has come
to our attention which leads us to believe that the Offering Memorandum, or any amendment
or supplement thereto, or any Exchange Act Report or document incorporated by reference
therein contained on the date thereof, or, contains as of the date hereof, any untrue
statement of a material fact or omitted as of the date thereof or, omits to state as of the
date hereof, any material fact required to be stated therein or necessary to make the
statements therein, in light of the circumstances in which they were made, not misleading.

 

 

Exhibit B

FORM OF LOCK-UP PURSUANT TO SECTION 5(G)

August •, 2005

Merrill Lynch, Pierce, Fenner & Smith

Incorporated,

4 World Financial Center

New York, New York 10080

Citigroup Global Markets Inc.

388 Greenwich Street

New York, New York 10013

          Re:  Proposed Offering by Human Genome Sciences, Inc.

Dear Sirs:

     The undersigned understands that Merrill Lynch, Pierce, Fenner & Smith Incorporated (“Merrill
Lynch”) and Citigroup Global Markets Inc. (“Citigroup,” collectively, the “Initial Purchasers”)
propose to enter into a Purchase Agreement (the “Purchase Agreement”) with Human Genome Sciences,
Inc., a Delaware corporation (the “Company”), providing for the offering (the “Offering”) pursuant
to Rule 144A under the Securities Act of 1933, as amended (the “1933 Act”) by the several Initial
Purchasers of $230,000,000 aggregate principal amount of the Company’s 2 1/4% Convertible Subordinated
Notes due 2012 (the “Securities”). Capitalized terms used herein and not otherwise defined shall
have the meanings set forth in the Purchase Agreement.

     In consideration of the Initial Purchasers’ agreement to purchase and make the Offering of the
Securities, and for other good and valuable consideration, the receipt and sufficiency of which are
hereby acknowledged, the undersigned agrees with each Initial Purchaser to be named in the Purchase
Agreement that, during a period of 45 days after the date of the Offering Memorandum, the
undersigned will not, without the prior written consent of Merrill Lynch and Citigroup, directly or
indirectly, (i) offer, pledge, sell, contract to sell, sell any option or contract to purchase,
purchase any option or contract to sell, grant any option, right or warrant for the sale of, or
lend or otherwise dispose of or transfer any of the Company’s Common Stock, $0.01 par value per
share (the “Common Stock”) or any securities convertible into or exercisable or exchangeable for or
repayable with Common Stock, whether such securities are owned at the date of the Offering
Memorandum or whether they are acquired during the 45 day period after the date of the Offering
Memorandum; (ii) request that the Company file a registration statement for any Common Stock or any
securities convertible into or exercisable or exchangeable for or repayable with Common Stock or
(iii) enter into any swap or any other agreement or any other transaction that transfers, in whole
or in part, the economic consequences of ownership of any Common Stock or any securities
convertible into or exercisable or exchangeable for or repayable with Common Stock, whether any
such swap or transaction above is to be settled by delivery of our Common Stock or such other
securities, in cash or otherwise. Notwithstanding the foregoing, a transfer of Common Stock to a
family member or a trust for the benefit of the undersigned or a family member may be made,
provided the transferee agrees in writing to be bound by the terms

 

 

of this lock-up agreement as if it were a party hereto. Notwithstanding the restrictions set
forth in clause (i) above, the undersigned may sell, transfer or otherwise dispose of not more than
200,000 shares of Common Stock.

     In furtherance of the foregoing, the Company, and any duly appointed transfer agent for the
registration or transfer of the securities described herein, are hereby authorized to decline to
make any transfer of securities if such transfer would constitute a violation or breach of this
lock-up agreement.

     The undersigned hereby represents and warrants that the undersigned has full power and
authority to enter into this lock-up agreement. All authority herein conferred or agreed to be
conferred and any obligations of the undersigned shall be binding upon the successors, assigns,
heirs or personal representatives of the undersigned.

     The undersigned understands that, if the Purchase Agreement does not become effective, or if
the Purchase Agreement (other than the provisions thereof which survive termination) shall
terminate or be terminated prior to payment for and delivery of the Securities to be sold
thereunder, the undersigned shall be released from all obligations under this lock-up agreement.

     The undersigned understands that the Initial Purchasers are entering into the Purchase
Agreement and proceeding with the Offering in reliance upon this lock-up agreement.

     This lock-up agreement shall be governed by and construed in accordance with the laws of the
State of New York, without regard to the conflict of laws principles thereof.

	 	 	 	 	 
	 	 	Very truly yours,
	 
	 	 	 	 
	 

	 	Signature:	 	 
	 	 	 	 	 
	 
	 	 	 	 
	 

	 	Print Name:

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