Document:

EX-4.3

 

EXHIBIT 4.3

     This Security is a Global Security within the meaning of the Indenture hereinafter
referred to and is registered in the name of The Depositary Trust Company (the “Depositary”) or a
nominee of the Depositary. This Security is exchangeable for Securities registered in the name of a
person other than the Depositary or its nominee only in the limited circumstances described in the
Indenture and may not be transferred except as a whole by the Depositary to a nominee of the
Depositary or by a nominee of the Depositary to the Depositary or another nominee of the
Depositary. Unless this Security is presented by an authorized representative of the Depository
(55 Water Street, New York) to The Chubb Corporation or its agent for registration of transfer,
exchange or payment, and any Security issued is registered in the name of Cede & Co. or such other
name as requested by an authorized representative of the Depository and any payment hereon is made
to Cede & Co., ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY A PERSON IS
WRONGFUL inasmuch as the registered owner hereof, Cede & Co., has an interest herein.

 

			
	No. 1

Issue Date: March 29, 2007
	 	Principal Amount: $500,000,000

CUSIP: 171232AP6

THE CHUBB CORPORATION

6.375% Directly-Issued Subordinated Capital Securities (DISCSSM) due 2067

     THE CHUBB CORPORATION, a corporation organized and existing under the laws of New Jersey
(hereinafter called the “Company”, which term includes any successor Person under the Indenture
hereinafter referred to), for value received, hereby promises to pay to CEDE & CO., or registered
assigns, the principal sum of five hundred million Dollars ($500,000,000) as may be revised from
time to time on Schedule I hereto, and all accrued and unpaid interest thereof on April 15, 2037,
or if such day is not a Business Day, the following Business Day (the “Scheduled Maturity Date”) or
any subsequent Interest Payment Date (as hereinafter defined) to the extent set forth in the First
Supplemental Indenture (as hereinafter defined). If that amount is not paid in full on the
Scheduled Maturity Date or any subsequent Interest Payment Date, the remaining amount, together
with accrued and unpaid interest thereof, will be due and payable on the Final Maturity Date. The
Final Maturity Date will be March 29, 2067, or if such day is not a Business Day, the following
Business Day. Capitalized terms used herein and not otherwise defined shall have the meaning
ascribed to those terms in the Indenture.

     The Company further promises to pay interest on said Outstanding principal sum from and
including March 29, 2007, or from and including the most recent Interest Payment Date on which
interest has been paid or duly provided for, semi-annually (subject to deferral as set forth herein
and in the First Supplemental Indenture) in arrears on October 15 and April 15 of each year,
commencing on October 15, 2007, at the rate of 6.375% per annum (computed on the basis of a 360-day
year comprised of twelve 30-day months) to but excluding April 15, 2017 or earlier redemption or
repayment date of this Security, and thereafter to pay interest on said Outstanding principal sum
quarterly in arrears on July 15, October 15, January 15, and April 15

 

 

of each year (each such date and, together with such October 15 and April 15 of each year, an
“Interest Payment Date”), at a floating annual rate equal to Three-Month LIBOR plus 2.25% (computed
on the basis of a 360-day year and the actual number of days elapsed), until the principal hereof
shall have become due and payable, plus Additional Interest, if any, until the principal hereof is
paid or duly provided for or made available for payment. Accrued interest that is not paid on the
applicable Interest Payment Date, including interest deferred pursuant to Section 2.05 of the First
Supplemental Indenture, will bear Additional Interest, to the extent permitted by law, at the
interest rate in effect for this Security from time to time, from the relevant Interest Payment
Date, compounded on each subsequent Interest Payment Date. In the event that any Semi-Annual
Interest Payment Date on which interest is payable on this Security is not a Business Day, then
payment of the interest payable on such date will be made on the next succeeding day that is a
Business Day (and, in the case of payments on or prior to April 15, 2017, without any interest or
other payment in respect of any such delay) with the same force and effect as if made on the date
the payment was originally payable. In the event that any Quarterly Interest Payment Date on which
interest is payable on this Security is not a Business Day, then payment of the interest payable on
such date shall be postponed to the next succeeding day that is a Business Day, provided that if
such Business Day is in the next succeeding calendar month, such Quarterly Interest Payment Date
shall be the immediately preceding Business Day. Interest will accrue to but excluding the date
that interest is actually paid. A “Business Day” shall mean any day other than (i) a Saturday or
Sunday, (ii) a day on which banking institutions in The City of New York are authorized or required
by law or executive order to remain closed or (iii) a day on which the Corporate Trust Office of
the Trustee, is closed for business. The interest installment so payable, and punctually paid or
duly provided for, on any Interest Payment Date will, as provided in the Indenture, be paid to the
Person in whose name this Security is registered at the close of business on the Regular Record
Date next preceding the relevant Interest Payment Date, which, with respect to a Semi-Annual
Interest Payment Date, shall be October 1 or April 1, as the case may be, immediately preceding
such Semi-Annual Interest Payment Date and, with respect to a Quarterly Interest Payment Date, the
15th day preceding such Quarterly Interest Payment Date. Any such interest installment not so
punctually paid or duly provided for shall forthwith cease to be payable to the Holder on such
Regular Record Date and may either be paid to the Person in whose name this Security is registered
at the close of business on a Special Record Date for the payment of such Defaulted Interest to be
fixed by the Trustee, notice whereof shall be given to Holders of Securities of this series not
less than 10 days prior to such Special Record Date, or be paid at any time in any other lawful
manner not inconsistent with the requirements of any securities exchange on which the Securities of
this series may be listed, and upon such notice as may be required by such exchange, all as more
fully provided in the Indenture.

     So long as no Event of Default has occurred and is continuing, the Company shall have the
right at any time or from time to time during the term of this Security to defer payment of
interest on this Security for one or more consecutive interest payment periods (each a “Deferral
Period”) that do not exceed 10 years, during which Deferral Periods the Company shall have the
right, subject to Sections 2.05 and 2.06 of the First Supplemental Indenture, to make partial
payments of interest on any Interest Payment Date, and at the end of which the Company shall pay
all interest then accrued and unpaid (together with Additional Interest thereon to the extent
permitted by applicable law); provided, however, that no Deferral Period shall extend beyond the
Final Maturity Date, or the earlier accelerated maturity date of this Security or other

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repayment or redemption in full of this Security. Upon the termination of any Deferral Period
and upon the payment of all deferred interest then due, the Company may elect to begin a new
Deferral Period, subject to the above requirements. Deferred interest on the Security will bear
interest at the then applicable interest rate, compounded on each Interest Payment Date, subject to
applicable law. No interest shall be due and payable during a Deferral Period except at the end
thereof. Additional limitations may apply, pursuant to Section 3.02 of the First Supplemental
Indenture, if any Deferral Period lasts longer than one year.

     So long as any Securities remain Outstanding, if the Company has given notice of its election
to defer interest payments on the Securities but the related Deferral Period has not yet commenced
or a Deferral Period is continuing, the Company shall not, and shall not permit any Subsidiary of
the Company to, (i) declare or pay any dividends or distributions on, or redeem, purchase, acquire
or make a liquidation payment with respect to, any shares of the Company’s capital stock, (ii) make
any payment of principal of, or interest or premium, if any, on or repay, purchase or redeem any
debt securities of the Company that rank upon the Company’s liquidation, dissolution or winding-up
on a parity with this Security (including this Security, the “Pari Passu Securities” ), or junior
to this Security or (iii) make any guarantee payments regarding any guarantee issued by the Company
of the securities of any Subsidiary if the guarantee ranks upon the Company’s liquidation,
dissolution or winding-up on a parity with or junior to this Security (other than (a) any purchase,
redemption or other acquisition of shares of the Company’s capital stock by the Company in
connection with (1) any employment contract, benefit plan or other similar arrangement with or for
the benefit of any one or more of its employees, officers, directors, consultants or independent
contractors, (2) the satisfaction of the Company’s obligations pursuant to any contract entered
into in the ordinary course of business prior to the beginning of the applicable Deferral Period,
(3) a dividend reinvestment or shareholder purchase plan, or (4) the issuance of the Company’s
capital stock, or securities convertible into or exercisable for such capital stock, as
consideration in an acquisition transaction entered into prior to the applicable Deferral Period,
(b) any exchange, redemption or conversion of any class or series of the Company’s capital stock,
or the capital stock of one of its Subsidiaries, for any other class or series of its capital
stock, or of any class or series of its indebtedness for any class or series of its capital stock,
(c) any purchase of fractional interests in shares of the Company’s capital stock pursuant to the
conversion or exchange provisions of such capital stock or the securities being converted or
exchanged, (d) any declaration of a dividend in connection with any shareholder rights plan, or the
issuance of rights, stock or other property under any shareholder rights plan, or the redemption or
purchase of rights pursuant thereto, (e) any dividend in the form of stock, warrants, options or
other rights where the dividend stock or stock issuable upon exercise of such warrants, options or
other rights is the same stock as that on which the dividend is being paid or ranks equally with or
junior to such stock, (f) any payment of current or deferred interest on Pari Passu Securities that
is made pro rata to the amounts due on such Pari Passu Securities (including this Security);
provided that such payments are made in accordance with Section 2.06(c) of the First Supplemental
Indenture to the extent it applies, and any payments of deferred interest on Pari Passu Securities
that, if not made, would cause the Company to breach the terms of the instrument governing such
Pari Passu Securities; (g) any payment of principal in respect of Pari Passu Securities having the
same scheduled maturity date as this Security, as required under a provision of such other Pari
Passu Securities that is substantially the same as the provisions in Section 2.02 of the First
Supplemental Indenture, and that is made on a pro rata basis among one or more series of Pari Passu
Securities (including this

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Security) having such a provision and this Security or (h) any repayment or redemption of a
security necessary to avoid a breach of the instrument governing the same. In addition, if any
Deferral Period lasts longer than one year, the restrictions on the Company’s ability to redeem or
purchase APM Qualifying Securities or any of its securities that on its bankruptcy or liquidation
rank pari passu, or junior, as applicable, to such APM Qualifying Securities will continue until
the first anniversary of the date on which all deferred interest on this Security has been paid,
subject to the exceptions listed in clauses (a) through (h) above. However, if the Company is
involved in a Business Combination where immediately after its consummation (i) more than 50% of
the voting stock of the Person that is the surviving or resulting entity of such Business
Combination or the Person to whom all or substantially all of the Company’s property or assets are
conveyed, transferred or leased in such Business Combination, is owned by the shareholders of the
other party to such Business Combination or Person to whom all or substantially all of the
Company’s property or assets are conveyed, transferred or leased, or (ii) Continuing Directors
cease for any reason to constitute a majority of the directors of the surviving or resulting entity
or Person to whom all or substantially all of the Company’s property or assets are conveyed,
transferred or leased, then the immediately preceding sentence will not apply during the Deferral
Period that is terminated on the next Interest Payment Date following the date of consummation of
such Business Combination.

     The Company shall give written notice of its election to begin or extend any Deferral Period
to the Trustee and the Holders of this Security at least one Business Day and not more than sixty
Business Days before the next Interest Payment Date. Notice of the Company’s election of a
Deferral Period shall be given to the Trustee and each Holder of this Security at such Holder’s
address appearing in the Security Register by first-class mail, postage prepaid.

     Payment of the principal of (and premium, if any) and interest on this Security will be made
at the office or agency of the Company maintained for that purpose in the United States, in such
coin or currency of the United States of America as at the time of payment is legal tender for
payment of public and private debts; provided, however, that at the option of the Company payment
of interest may be made (i) by check mailed to the address of the Person entitled thereto as such
address shall appear in the Securities Register or (ii) by wire transfer in immediately available
funds at such place and to such bank account as may be designated by the Person entitled thereto as
specified in the Securities Register in writing not less than ten days before the relevant Interest
Payment Date.

     The indebtedness evidenced by this Security is, to the extent provided in the Indenture,
subordinate and junior in right of payment to the prior payment in full of all Senior Indebtedness,
and this Security is issued subject to the provisions of the Indenture with respect thereto. Each
Holder of this Security, by accepting the same, (a) agrees to and shall be bound by such
provisions, (b) authorizes and directs the Trustee on his behalf to take such actions as may be
necessary or appropriate to effectuate the subordination so provided and (c) appoints the Trustee
his attorney-in-fact for any and all such purposes. Each Holder hereof, by his acceptance hereof,
waives all notice of the acceptance of the subordination provisions contained herein and in the
Indenture by each holder of Senior Indebtedness, whether now outstanding or hereafter incurred, and
waives reliance by each such holder upon said provisions.

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     The Company and, by acceptance of this Security or a beneficial interest in this Security,
each Holder hereof and any person acquiring a beneficial interest herein, agree to treat this
Security as indebtedness for United States federal income tax purposes.

     Reference is hereby made to the further provisions of this Security set forth on the reverse
hereof, which further provisions shall for all purposes have the same effect as if set forth at
this place.

     Unless the certificate of authentication hereon has been executed by the Trustee referred to
on the reverse hereof by manual signature, this Security shall not be entitled to any benefit under
the Indenture or be valid or obligatory for any purpose.

5

 

In WITNESS WHEREOF, the Company has caused this instrument to be duly executed.

	 	 	 	 	 
	 	THE CHUBB CORPORATION

 	 
	 	By:  	 /s/
Michael O'Reilly	 
	 	 	Name:  	Michael O'Reilly	 
	 	 	Title:	 Vice Chairman and Chief
Financial Officer	 
	 
	 	 	 
	 	By:  	
 /s/ W. Andrew Macan	 
	 	 	Name:  	W. Andrew Macan	 
	 	 	Title:  	 Vice President and Secretary	 
	 

TRUSTEE’S CERTIFICATE OF AUTHENTICATION

	 	 	 	 	 
	 	This is one of the Securities of the series

designated therein referred to in the

within-mentioned Indenture.

THE BANK OF NEW YORK TRUST
COMPANY, N.A.

 	 
	 	By:  	 /s/
Benita A. Vaughn	 
	 	 	Name: 	Benita A. Vaughn	 
	 	 	Title:  	Authorized Signatory	 
	 	 	Dated: 	March 29, 2007	 

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REVERSE OF DEBENTURES

     This Security is one of a duly authorized issue of securities of the Company, issued and to be
issued in one or more series under the Junior Subordinated Indenture, dated as of March 29, 2007
(herein called the “Base Indenture”), between the Company and The Bank of New York Trust Company,
N.A., as trustee (the “Trustee”), as amended and supplemented by the First Supplemental Indenture,
dated as of March 29, 2007, between the Company and the Trustee (the “First Supplemental
Indenture”, and together with the Base Indenture, the “Indenture”), to which Indenture and all
other indentures supplemental thereto reference is hereby made for a statement of the respective
rights, limitations of rights, duties and immunities thereunder of the Trustee, the Company and the
Holders of the Securities, and of the terms upon which the Securities are, and are to be,
authenticated and delivered. By the terms of the Indenture, the Securities are issuable in series
that may vary as to amount, date of maturity, rate of interest, rank and in any other respect
provided in the Indenture.

     All terms used in this Security that are defined in the Indenture shall have the meanings
assigned to them in the Indenture.

     The Securities shall be redeemable at the option of the Company in accordance with the terms
of the Indenture. In particular, the Debentures are redeemable:

     (a) in whole or in part, at the Company’s option at any time after the date of the
Indenture;

     (b) in whole but not in part, within 90 days after the occurrence of a Tax Event or a
Rating Agency Event;

provided that no partial redemption shall be effected (x) unless at least $25 million aggregate
principal amount of the Securities, excluding any Securities held by the Company or any of its
affiliates, remains Outstanding after giving effect to such redemption and (y) if the principal
amount has been accelerated and such acceleration has not been rescinded or unless all accrued and
unpaid interest, including deferred interest, has been paid in full on all Outstanding Securities
for all interest periods terminating on or before the redemption date.

     No sinking fund is provided for the Securities.

     The Indenture contains provisions for satisfaction, discharge and defeasance of the entire
indebtedness of this Security upon compliance by the Company with certain conditions set forth in
the Indenture.

     The Indenture permits, with certain exceptions as therein provided, the Company and the
Trustee at any time to enter into a supplemental indenture or indentures for the purpose of
modifying in any manner the rights and obligations of the Company and of the Holders of the
Securities, with the consent of the Holders of not less than a majority in principal amount of the
Outstanding Securities to be affected by such supplemental indenture. The Indenture also contains
provisions permitting Holders of specified percentages in principal amount of the Securities at the
time Outstanding, on behalf of the Holders of all Securities, to waive compliance by the Company
with certain provisions of the Indenture and certain past defaults

7

 

under the Indenture and their consequences. Any such consent or waiver by the Holder of this
Security shall be conclusive and binding upon such Holder and upon all future Holders of this
Security and of any Security issued upon the registration of transfer hereof or in exchange herefor
or in lieu hereof, whether or not notation of such consent or waiver is made upon this Security.

     As provided in and subject to the provisions of the Indenture, if an Event of Default with
respect to the Securities at the time Outstanding occurs and is continuing, then and in every such
case the Trustee or the Holders of not less than 25% in aggregate principal amount of the
Outstanding Securities may declare the entire principal amount and all accrued but unpaid interest
of all the Outstanding Securities to be due and payable immediately, by a notice in writing to the
Company (and to the Trustee if given by Holders), and upon such declaration, such amount shall
become immediately due and payable; provided that the payment of principal and interest (including
any Additional Interest) on such Securities shall remain subordinated to the extent provided in
Article Eleven of the Indenture.

     No reference herein to the Indenture and no provision of this Security or of the Indenture
shall alter or impair the obligation of the Company, which is absolute and unconditional, to pay
the principal of (and premium, if any) and interest on this Security at the times, place and rate,
and in the coin or currency, herein prescribed.

     As provided in the Indenture and subject to certain limitations therein set forth, the
transfer of this Security is registrable in the Securities Register, upon surrender of this
Security for registration of transfer at the office or agency of the Company maintained under
Section 1002 of the Indenture duly endorsed by, or accompanied by a written instrument of transfer
in form satisfactory to the Company and the Securities Registrar duly executed by, the Holder
hereof or his attorney duly authorized in writing, and thereupon one or more new Securities, of
authorized denominations and for the same aggregate principal amount, will be issued to the
designated transferee or transferees. No service charge shall be made for any such registration of
transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or
other governmental charge payable in connection therewith.

     Prior to due presentment of this Security for registration of transfer, the Company, the
Trustee and any agent of the Company or the Trustee may treat the Person in whose name this
Security is registered as the owner hereof for all purposes, whether or not this Security be
overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the
contrary.

     The Securities are issuable only in registered form without coupons in minimum denominations
of $1,000 and any integral multiples of $1,000 in excess thereof. As provided in the Indenture and
subject to certain limitations therein set forth, Securities are exchangeable for a like aggregate
principal amount of Securities of a different authorized denomination, as requested by the Holder
surrendering the same.

     The Company and, by its acceptance of this Security or a beneficial interest therein, the
Holder of, and any Person that acquires a beneficial interest in, this Security agree to treat the
Securities as indebtedness for United States Federal income tax purposes.

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THE INDENTURE AND THIS SECURITY SHALL BE GOVERNED BY AND

CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK.

This is one of the Securities referred to in the within mentioned Indenture.

ASSIGNMENT

FOR VALUE RECEIVED, the undersigned assigns and transfers this Security to:

 

 

 

(Insert assignee’s social security or tax identification number)

 

 

(Insert address and zip code of assignee)

agent to transfer this Security on the books of the Securities Registrar. The agent may substitute
another to act for him or her.

	 	 	 
	Dated:

	 	Signature:
	 

	 	Signature Guarantee:

(Sign exactly as your name appears on the other side of this Security)

Signatures must be guaranteed by an “eligible guarantor institution” meeting the requirements of
the Securities Registrar, which requirements include membership or participation in the Security
Transfer Agent Medallion Program (“STAMP”) or such other “signature guarantee program” as may be
determined by the Securities Registrar in addition to, or in substitution for, STAMP, all in
accordance with the Securities Exchange Act of 1934, as amended.

9

 

SCHEDULE I

SCHEDULE OF PRINCIPAL AMOUNT REDUCTIONS

Principal amount of Securities outstanding represented by this certificate as of March 29, 2007:
$500,000,000

Thereafter, the following decreases have been made:

	 	 	 	 	 	 	 
	 	 	Principal Amount	 	 	 	Notation Made by or
	Date of Redemption	 	Redeemed or	 	Principal Amount	 	on Behalf of the
	or Repurchase	 	Repurchased	 	Remaining	 	Trustee
	 
	 	 	 	 	 	 

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     This Security is a Global Security within the meaning of the Indenture hereinafter referred to
and is registered in the name of The Depositary Trust Company (the “Depositary”) or a nominee of
the Depositary. This Security is exchangeable for Securities registered in the name of a person
other than the Depositary or its nominee only in the limited circumstances described in the
Indenture and may not be transferred except as a whole by the Depositary to a nominee of the
Depositary or by a nominee of the Depositary to the Depositary or another nominee of the
Depositary. Unless this Security is presented by an authorized representative of the Depository
(55 Water Street, New York) to The Chubb Corporation or its agent for registration of transfer,
exchange or payment, and any Security issued is registered in the name of Cede & Co. or such other
name as requested by an authorized representative of the Depository and any payment hereon is made
to Cede & Co., ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY A PERSON IS
WRONGFUL inasmuch as the registered owner hereof, Cede & Co., has an interest herein.

			
	No. 2

Issue Date: March 29, 2007
	 	Principal Amount: $500,000,000

CUSIP: 171232AP6

THE CHUBB CORPORATION

6.375% Directly-Issued Subordinated Capital Securities (DISCSSM) due 2067

     THE CHUBB CORPORATION, a corporation organized and existing under the laws of New Jersey
(hereinafter called the “Company”, which term includes any successor Person under the Indenture
hereinafter referred to), for value received, hereby promises to pay to CEDE & CO., or registered
assigns, the principal sum of five hundred million Dollars ($500,000,000) as may be revised from
time to time on Schedule I hereto, and all accrued and unpaid interest thereof on April 15, 2037,
or if such day is not a Business Day, the following Business Day (the “Scheduled Maturity Date”) or
any subsequent Interest Payment Date (as hereinafter defined) to the extent set forth in the First
Supplemental Indenture (as hereinafter defined). If that amount is not paid in full on the
Scheduled Maturity Date or any subsequent Interest Payment Date, the remaining amount, together
with accrued and unpaid interest thereof, will be due and payable on the Final Maturity Date. The
Final Maturity Date will be March 29, 2067, or if such day is not a Business Day, the following
Business Day. Capitalized terms used herein and not otherwise defined shall have the meaning
ascribed to those terms in the Indenture.

     The Company further promises to pay interest on said Outstanding principal sum from and
including March 29, 2007, or from and including the most recent Interest Payment Date on which
interest has been paid or duly provided for, semi-annually (subject to deferral as set forth herein
and in the First Supplemental Indenture) in arrears on October 15 and April 15 of each year,
commencing on October 15, 2007, at the rate of 6.375% per annum (computed on the basis of a 360-day
year comprised of twelve 30-day months) to but excluding April 15, 2017 or earlier redemption or
repayment date of this Security, and thereafter to pay interest on said Outstanding principal sum
quarterly in arrears on July 15, October 15, January 15, and April 15

 

 

of each year (each such date and, together with such October 15 and April 15 of each year, an
“Interest Payment Date”), at a floating annual rate equal to Three-Month LIBOR plus 2.25% (computed
on the basis of a 360-day year and the actual number of days elapsed), until the principal hereof
shall have become due and payable, plus Additional Interest, if any, until the principal hereof is
paid or duly provided for or made available for payment. Accrued interest that is not paid on the
applicable Interest Payment Date, including interest deferred pursuant to Section 2.05 of the First
Supplemental Indenture, will bear Additional Interest, to the extent permitted by law, at the
interest rate in effect for this Security from time to time, from the relevant Interest Payment
Date, compounded on each subsequent Interest Payment Date. In the event that any Semi-Annual
Interest Payment Date on which interest is payable on this Security is not a Business Day, then
payment of the interest payable on such date will be made on the next succeeding day that is a
Business Day (and, in the case of payments on or prior to April 15, 2017, without any interest or
other payment in respect of any such delay) with the same force and effect as if made on the date
the payment was originally payable. In the event that any Quarterly Interest Payment Date on which
interest is payable on this Security is not a Business Day, then payment of the interest payable on
such date shall be postponed to the next succeeding day that is a Business Day, provided that if
such Business Day is in the next succeeding calendar month, such Quarterly Interest Payment Date
shall be the immediately preceding Business Day. Interest will accrue to but excluding the date
that interest is actually paid. A “Business Day” shall mean any day other than (i) a Saturday or
Sunday, (ii) a day on which banking institutions in The City of New York are authorized or required
by law or executive order to remain closed or (iii) a day on which the Corporate Trust Office of
the Trustee, is closed for business. The interest installment so payable, and punctually paid or
duly provided for, on any Interest Payment Date will, as provided in the Indenture, be paid to the
Person in whose name this Security is registered at the close of business on the Regular Record
Date next preceding the relevant Interest Payment Date, which, with respect to a Semi-Annual
Interest Payment Date, shall be October 1 or April 1, as the case may be, immediately preceding
such Semi-Annual Interest Payment Date and, with respect to a Quarterly Interest Payment Date, the
15th day preceding such Quarterly Interest Payment Date. Any such interest installment not so
punctually paid or duly provided for shall forthwith cease to be payable to the Holder on such
Regular Record Date and may either be paid to the Person in whose name this Security is registered
at the close of business on a Special Record Date for the payment of such Defaulted Interest to be
fixed by the Trustee, notice whereof shall be given to Holders of Securities of this series not
less than 10 days prior to such Special Record Date, or be paid at any time in any other lawful
manner not inconsistent with the requirements of any securities exchange on which the Securities of
this series may be listed, and upon such notice as may be required by such exchange, all as more
fully provided in the Indenture.

     So long as no Event of Default has occurred and is continuing, the Company shall have the
right at any time or from time to time during the term of this Security to defer payment of
interest on this Security for one or more consecutive interest payment periods (each a “Deferral
Period”) that do not exceed 10 years, during which Deferral Periods the Company shall have the
right, subject to Sections 2.05 and 2.06 of the First Supplemental Indenture, to make partial
payments of interest on any Interest Payment Date, and at the end of which the Company shall pay
all interest then accrued and unpaid (together with Additional Interest thereon to the extent
permitted by applicable law); provided, however, that no Deferral Period shall extend beyond the
Final Maturity Date, or the earlier accelerated maturity date of this Security or other

2

 

repayment or redemption in full of this Security. Upon the termination of any Deferral Period
and upon the payment of all deferred interest then due, the Company may elect to begin a new
Deferral Period, subject to the above requirements. Deferred interest on the Security will bear
interest at the then applicable interest rate, compounded on each Interest Payment Date, subject to
applicable law. No interest shall be due and payable during a Deferral Period except at the end
thereof. Additional limitations may apply, pursuant to Section 3.02 of the First Supplemental
Indenture, if any Deferral Period lasts longer than one year.

     So long as any Securities remain Outstanding, if the Company has given notice of its election
to defer interest payments on the Securities but the related Deferral Period has not yet commenced
or a Deferral Period is continuing, the Company shall not, and shall not permit any Subsidiary of
the Company to, (i) declare or pay any dividends or distributions on, or redeem, purchase, acquire
or make a liquidation payment with respect to, any shares of the Company’s capital stock, (ii) make
any payment of principal of, or interest or premium, if any, on or repay, purchase or redeem any
debt securities of the Company that rank upon the Company’s liquidation, dissolution or winding-up
on a parity with this Security (including this Security, the “Pari Passu Securities” ), or junior
to this Security or (iii) make any guarantee payments regarding any guarantee issued by the Company
of the securities of any Subsidiary if the guarantee ranks upon the Company’s liquidation,
dissolution or winding-up on a parity with or junior to this Security (other than (a) any purchase,
redemption or other acquisition of shares of the Company’s capital stock by the Company in
connection with (1) any employment contract, benefit plan or other similar arrangement with or for
the benefit of any one or more of its employees, officers, directors, consultants or independent
contractors, (2) the satisfaction of the Company’s obligations pursuant to any contract entered
into in the ordinary course of business prior to the beginning of the applicable Deferral Period,
(3) a dividend reinvestment or shareholder purchase plan, or (4) the issuance of the Company’s
capital stock, or securities convertible into or exercisable for such capital stock, as
consideration in an acquisition transaction entered into prior to the applicable Deferral Period,
(b) any exchange, redemption or conversion of any class or series of the Company’s capital stock,
or the capital stock of one of its Subsidiaries, for any other class or series of its capital
stock, or of any class or series of its indebtedness for any class or series of its capital stock,
(c) any purchase of fractional interests in shares of the Company’s capital stock pursuant to the
conversion or exchange provisions of such capital stock or the securities being converted or
exchanged, (d) any declaration of a dividend in connection with any shareholder rights plan, or the
issuance of rights, stock or other property under any shareholder rights plan, or the redemption or
purchase of rights pursuant thereto, (e) any dividend in the form of stock, warrants, options or
other rights where the dividend stock or stock issuable upon exercise of such warrants, options or
other rights is the same stock as that on which the dividend is being paid or ranks equally with or
junior to such stock, (f) any payment of current or deferred interest on Pari Passu Securities that
is made pro rata to the amounts due on such Pari Passu Securities (including this Security);
provided that such payments are made in accordance with Section 2.06(c) of the First Supplemental
Indenture to the extent it applies, and any payments of deferred interest on Pari Passu Securities
that, if not made, would cause the Company to breach the terms of the instrument governing such
Pari Passu Securities; (g) any payment of principal in respect of Pari Passu Securities having the
same scheduled maturity date as this Security, as required under a provision of such other Pari
Passu Securities that is substantially the same as the provisions in Section 2.02 of the First
Supplemental Indenture, and that is made on a pro rata basis among one or more series of Pari Passu
Securities (including this

3

 

Security) having such a provision and this Security or (h) any repayment or redemption of a
security necessary to avoid a breach of the instrument governing the same. In addition, if any
Deferral Period lasts longer than one year, the restrictions on the Company’s ability to redeem or
purchase APM Qualifying Securities or any of its securities that on its bankruptcy or liquidation
rank pari passu, or junior, as applicable, to such APM Qualifying Securities will continue until
the first anniversary of the date on which all deferred interest on this Security has been paid,
subject to the exceptions listed in clauses (a) through (h) above. However, if the Company is
involved in a Business Combination where immediately after its consummation (i) more than 50% of
the voting stock of the Person that is the surviving or resulting entity of such Business
Combination or the Person to whom all or substantially all of the Company’s property or assets are
conveyed, transferred or leased in such Business Combination, is owned by the shareholders of the
other party to such Business Combination or Person to whom all or substantially all of the
Company’s property or assets are conveyed, transferred or leased, or (ii) Continuing Directors
cease for any reason to constitute a majority of the directors of the surviving or resulting entity
or Person to whom all or substantially all of the Company’s property or assets are conveyed,
transferred or leased, then the immediately preceding sentence will not apply during the Deferral
Period that is terminated on the next Interest Payment Date following the date of consummation of
such Business Combination.

     The Company shall give written notice of its election to begin or extend any Deferral Period
to the Trustee and the Holders of this Security at least one Business Day and not more than sixty
Business Days before the next Interest Payment Date. Notice of the Company’s election of a
Deferral Period shall be given to the Trustee and each Holder of this Security at such Holder’s
address appearing in the Security Register by first-class mail, postage prepaid.

     Payment of the principal of (and premium, if any) and interest on this Security will be made
at the office or agency of the Company maintained for that purpose in the United States, in such
coin or currency of the United States of America as at the time of payment is legal tender for
payment of public and private debts; provided, however, that at the option of the Company payment
of interest may be made (i) by check mailed to the address of the Person entitled thereto as such
address shall appear in the Securities Register or (ii) by wire transfer in immediately available
funds at such place and to such bank account as may be designated by the Person entitled thereto as
specified in the Securities Register in writing not less than ten days before the relevant Interest
Payment Date.

     The indebtedness evidenced by this Security is, to the extent provided in the Indenture,
subordinate and junior in right of payment to the prior payment in full of all Senior Indebtedness,
and this Security is issued subject to the provisions of the Indenture with respect thereto. Each
Holder of this Security, by accepting the same, (a) agrees to and shall be bound by such
provisions, (b) authorizes and directs the Trustee on his behalf to take such actions as may be
necessary or appropriate to effectuate the subordination so provided and (c) appoints the Trustee
his attorney-in-fact for any and all such purposes. Each Holder hereof, by his acceptance hereof,
waives all notice of the acceptance of the subordination provisions contained herein and in the
Indenture by each holder of Senior Indebtedness, whether now outstanding or hereafter incurred, and
waives reliance by each such holder upon said provisions.

4

 

     The Company and, by acceptance of this Security or a beneficial interest in this Security,
each Holder hereof and any person acquiring a beneficial interest herein, agree to treat this
Security as indebtedness for United States federal income tax purposes.

     Reference is hereby made to the further provisions of this Security set forth on the reverse
hereof, which further provisions shall for all purposes have the same effect as if set forth at
this place.

     Unless the certificate of authentication hereon has been executed by the Trustee referred to
on the reverse hereof by manual signature, this Security shall not be entitled to any benefit under
the Indenture or be valid or obligatory for any purpose.

5

 

In WITNESS WHEREOF, the Company has caused this instrument to be duly executed.

	 	 	 	 	 
	 	THE CHUBB CORPORATION

 	 
	 	By:  	 /s/
Michael O'Reilly	 
	 	 	Name:  	 Michael O'Reilly	 
	 	 	Title:  	 Vice Chairman and Chief Financial Officer	 
	 
	 	 	 
	 	By:  	
 /s/ W. Andrew Macan	 
	 	 	Name:  	 W. Andrew Macan	 
	 	 	Title:  	Vice President and Secretary	 
	 

TRUSTEE’S CERTIFICATE OF AUTHENTICATION

	 	 	 	 	 
	 	This is one of the Securities of the series

designated therein referred to in the

within-mentioned Indenture.

THE BANK OF NEW YORK TRUST
COMPANY, N.A.

 	 
	 	By:  	 /s/
Benita A. Vaughn	 
	 	 	Name:  	 Benita A. Vaughn	 
	 	 	Title:  	Authorized Signatory
Dated: March 29, 2007	 

6

 

	 	 	 	 	 

REVERSE OF DEBENTURES

     This Security is one of a duly authorized issue of securities of the Company, issued and to be
issued in one or more series under the Junior Subordinated Indenture, dated as of March 29, 2007
(herein called the “Base Indenture”), between the Company and The Bank of New York Trust Company,
N.A., as trustee (the “Trustee”), as amended and supplemented by the First Supplemental Indenture,
dated as of March 29, 2007, between the Company and the Trustee (the “First Supplemental
Indenture”, and together with the Base Indenture, the “Indenture”), to which Indenture and all
other indentures supplemental thereto reference is hereby made for a statement of the respective
rights, limitations of rights, duties and immunities thereunder of the Trustee, the Company and the
Holders of the Securities, and of the terms upon which the Securities are, and are to be,
authenticated and delivered. By the terms of the Indenture, the Securities are issuable in series
that may vary as to amount, date of maturity, rate of interest, rank and in any other respect
provided in the Indenture.

     All terms used in this Security that are defined in the Indenture shall have the meanings
assigned to them in the Indenture.

     The Securities shall be redeemable at the option of the Company in accordance with the terms
of the Indenture. In particular, the Debentures are redeemable:

     (a) in whole or in part, at the Company’s option at any time after the date of the
Indenture;

     (b) in whole but not in part, within 90 days after the occurrence of a Tax Event or a
Rating Agency Event;

provided that no partial redemption shall be effected (x) unless at least $25 million aggregate
principal amount of the Securities, excluding any Securities held by the Company or any of its
affiliates, remains Outstanding after giving effect to such redemption and (y) if the principal
amount has been accelerated and such acceleration has not been rescinded or unless all accrued and
unpaid interest, including deferred interest, has been paid in full on all Outstanding Securities
for all interest periods terminating on or before the redemption date.

     No sinking fund is provided for the Securities.

     The Indenture contains provisions for satisfaction, discharge and defeasance of the entire
indebtedness of this Security upon compliance by the Company with certain conditions set forth in
the Indenture.

     The Indenture permits, with certain exceptions as therein provided, the Company and the
Trustee at any time to enter into a supplemental indenture or indentures for the purpose of
modifying in any manner the rights and obligations of the Company and of the Holders of the
Securities, with the consent of the Holders of not less than a majority in principal amount of the
Outstanding Securities to be affected by such supplemental indenture. The Indenture also contains
provisions permitting Holders of specified percentages in principal amount of the Securities at the
time Outstanding, on behalf of the Holders of all Securities, to waive compliance by the Company
with certain provisions of the Indenture and certain past defaults

7

 

under the Indenture and their consequences. Any such consent or waiver by the Holder of this
Security shall be conclusive and binding upon such Holder and upon all future Holders of this
Security and of any Security issued upon the registration of transfer hereof or in exchange herefor
or in lieu hereof, whether or not notation of such consent or waiver is made upon this Security.

     As provided in and subject to the provisions of the Indenture, if an Event of Default with
respect to the Securities at the time Outstanding occurs and is continuing, then and in every such
case the Trustee or the Holders of not less than 25% in aggregate principal amount of the
Outstanding Securities may declare the entire principal amount and all accrued but unpaid interest
of all the Outstanding Securities to be due and payable immediately, by a notice in writing to the
Company (and to the Trustee if given by Holders), and upon such declaration, such amount shall
become immediately due and payable; provided that the payment of principal and interest (including
any Additional Interest) on such Securities shall remain subordinated to the extent provided in
Article Eleven of the Indenture.

     No reference herein to the Indenture and no provision of this Security or of the Indenture
shall alter or impair the obligation of the Company, which is absolute and unconditional, to pay
the principal of (and premium, if any) and interest on this Security at the times, place and rate,
and in the coin or currency, herein prescribed.

     As provided in the Indenture and subject to certain limitations therein set forth, the
transfer of this Security is registrable in the Securities Register, upon surrender of this
Security for registration of transfer at the office or agency of the Company maintained under
Section 1002 of the Indenture duly endorsed by, or accompanied by a written instrument of transfer
in form satisfactory to the Company and the Securities Registrar duly executed by, the Holder
hereof or his attorney duly authorized in writing, and thereupon one or more new Securities, of
authorized denominations and for the same aggregate principal amount, will be issued to the
designated transferee or transferees. No service charge shall be made for any such registration of
transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or
other governmental charge payable in connection therewith.

     Prior to due presentment of this Security for registration of transfer, the Company, the
Trustee and any agent of the Company or the Trustee may treat the Person in whose name this
Security is registered as the owner hereof for all purposes, whether or not this Security be
overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the
contrary.

     The Securities are issuable only in registered form without coupons in minimum denominations
of $1,000 and any integral multiples of $1,000 in excess thereof. As provided in the Indenture and
subject to certain limitations therein set forth, Securities are exchangeable for a like aggregate
principal amount of Securities of a different authorized denomination, as requested by the Holder
surrendering the same.

     The Company and, by its acceptance of this Security or a beneficial interest therein, the
Holder of, and any Person that acquires a beneficial interest in, this Security agree to treat the
Securities as indebtedness for United States Federal income tax purposes.

8

 

THE INDENTURE AND THIS SECURITY SHALL BE GOVERNED BY AND

CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK.

This is one of the Securities referred to in the within mentioned Indenture.

ASSIGNMENT

FOR VALUE RECEIVED, the undersigned assigns and transfers this Security to:

 

 

 

(Insert assignee’s social security or tax identification number)

 

 

(Insert address and zip code of assignee)

agent to transfer this Security on the books of the Securities Registrar. The agent may substitute
another to act for him or her.

	 	 	 
	Dated:

	 	Signature:
	 

	 	Signature Guarantee:

(Sign exactly as your name appears on the other side of this Security)

Signatures must be guaranteed by an “eligible guarantor institution” meeting the requirements of
the Securities Registrar, which requirements include membership or participation in the Security
Transfer Agent Medallion Program (“STAMP”) or such other “signature guarantee program” as may be
determined by the Securities Registrar in addition to, or in substitution for, STAMP, all in
accordance with the Securities Exchange Act of 1934, as amended.

9

 

SCHEDULE I

SCHEDULE OF PRINCIPAL AMOUNT REDUCTIONS

Principal amount of Securities outstanding represented by this certificate as of March 29, 2007:
$500,000,000

Thereafter, the following decreases have been made:

	 	 	 	 	 	 	 
	 	 	Principal Amount	 	 	 	Notation Made by or
	Date of Redemption	 	Redeemed or	 	Principal Amount	 	on Behalf of the
	or Repurchase	 	Repurchased	 	Remaining	 	Trustee
	 
	 	 	 	 	 	 

10<PAGE>
                                                                     EXHIBIT 4.2

                           THIRD AMENDED AND RESTATED
                            INVESTOR RIGHTS AGREEMENT

            THIRD AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT, dated
September 13, 2006 (this "Agreement"), by and among Amicus Therapeutics, Inc., a
Delaware corporation (the "Company"), the parties listed on Schedule I hereto
(the "Investors") and the parties listed on Schedule II hereto.

            WHEREAS, the Company and certain of the Investors are parties to the
Second Amended and Restated Investor Rights Agreement, dated August 17, 2005, as
amended by that certain Amendment, dated as of May 16, 2006 (as amended the
"Existing Investor Rights Agreement") and hold sufficient voting power to amend
the Existing Investor Rights Agreement (the "Amending Investors"); and

            WHEREAS, pursuant to the Series D Preferred Stock Purchase
Agreement, dated September 13, 2006 (the "Series D Stock Purchase Agreement"),
by and between the Company and each of the parties identified on Schedule I
thereto, the Company has agreed to issue and sell to such parties an aggregate
of 36,978,145 shares, par value $0.01 per share, of Series D Convertible
Preferred Stock of the Company (the "Series D Preferred Stock"); and

            WHEREAS, in order to induce each of the Investors to purchase its
shares of Series D Preferred Stock, the Company and the Amending Investors are
entering into this Agreement to, among other things, amend and restate the
Existing Investor Rights Agreement in its entirety.

            NOW, THEREFORE, in consideration of the mutual covenants and
agreements set forth herein and for good and valuable consideration, the receipt
and adequacy of which are hereby acknowledged, the parties hereto amend and
restate the Existing Investor Rights Agreement as follows:

      1. Definitions. As used in this Agreement the following terms have the
meanings indicated:

      "Agreement" means this Third Amended and Restated Investor Rights
Agreement as the same may be amended, supplemented or modified in accordance
with the terms hereof.

      "Amending Investors" has the meaning set forth in the recitals to this
Agreement.

      "Approved Underwriter" has the meaning set forth in Section 3(f) of this
Agreement.

      "Business Day" means any day other than a Saturday, Sunday or other day on
which commercial banks in the State of Delaware are authorized or required by
law or executive order to close.

      "Closing Price" means, with respect to the Registrable Securities, as of
the date of determination, (a) the closing price per share of a Registrable
Security on such date published in

<PAGE>

The Wall Street Journal or, if no such closing price on such date is published
in The Wall Street Journal, the average of the closing bid and asked prices on
such date, as officially reported on the principal national securities exchange
(including, without limitation, The Nasdaq Stock Market, Inc.) on which the
Registrable Securities are then listed or admitted to trading; or (b) if the
Registrable Securities are not then listed or admitted to trading on any
national securities exchange but are designated as national market system
securities by the NASD, the last trading price per share of a Registrable
Security on such date; or (c) if there shall have been no trading on such date
or if the Registrable Securities are not so designated, the average of the
reported closing bid and asked prices of the Registrable Securities on such date
as shown by The Nasdaq Stock Market, Inc. (or its successor) and reported by any
member firm of The New York Stock Exchange, Inc. selected by the Company; or (d)
if none of (a), (b) or (c) is applicable, a market price per share determined in
good faith by the Company's Board of Directors. If trading is conducted on a
continuous basis on any exchange, then the closing price shall be at 4:00 P.M.
New York City time.

      "Common Stock" means the Common Stock, par value $0.01 per share, of the
Company or any other capital stock of the Company into which such stock is
reclassified or reconstituted.

      "Company" has the meaning set forth in the preamble to this Agreement.

      "Company Underwriter" has the meaning set forth in Section 4(a) of this
Agreement.

      "Demand Registration" has the meaning set forth in Section 3(a) of this
Agreement.

      "Exchange Act" means the Securities Exchange Act of 1934, as amended, and
the rules and regulations of the SEC thereunder.

      "Existing Investor Rights Agreement" has the meaning set forth in the
recitals to this Agreement.

      "GECC" means General Electric Capital Corporation, a Delaware corporation.

      "GECC Warrant" means the warrant to purchase 40,000 shares of Common Stock
at an exercise price of $0.75 per share, issued by the Company to GECC on August
28, 2002.

      "Holder" means any person owning Registrable Securities.

      "Holders' Counsel" has the meaning set forth in Section 7(a)(i) of this
Agreement.

      "Incidental Registration" has the meaning set forth in Section 4(a) of
this Agreement.

      "Indemnified Party" has the meaning set forth in Section 8(c) of this
Agreement.

      "Indemnifying Party" has the meaning set forth in Section 8(c) of this
Agreement.

      "Initial Public Offering" means the initial public offering of the shares
of Common Stock of the Company pursuant to an effective Registration Statement
filed under the Securities Act.

                                      -2-
<PAGE>

      "Initiating Holders" has the meaning set forth in Section 3(a) of this
Agreement.

      "Inspector" has the meaning set forth in Section 7(a)(vii) of this
Agreement.

      "Investors" has the meaning set forth in the preamble to this Agreement.

      "IPO Effectiveness Date" means the date upon which the Company closes its
Initial Public Offering.

      "Liabilities" has the meaning set forth in Section 8(a) of this Agreement.

      "Market Price" means, on any date of determination, the average of the
daily Closing Price of the Registrable Securities for the immediately preceding
thirty (30) days on which the national securities exchanges are open for
trading.

      "Mount Sinai" means Mount Sinai School of Medicine of New York University.

      "Mount Sinai Shares" means the 1,742,000 shares of Common Stock issued to
Mount Sinai on April 15, 2002 and held by Mount Sinai.

      "NASD" means the National Association of Securities Dealers, Inc.

      "Person" means any individual, firm, corporation, partnership, limited
liability company, trust, incorporated or unincorporated association, joint
venture, joint stock company, government (or an agency or political subdivision
thereof) or other entity of any kind, and shall include any successor (by merger
or otherwise) of such entity.

      "Registration Expenses" has the meaning set forth in Section 7(d) of this
Agreement.

      "Registrable Securities" means (a) the Common Stock of the Company issued
or issuable upon conversion of the Series A Preferred Stock, the Series B
Preferred Stock, the Series C Preferred Stock or the Series D Preferred Stock;
(b) the Mount Sinai Shares; (c) any Common Stock of the Company issued as (or
issuable upon the conversion or exercise of any warrant, right or other security
which is issued as) a dividend or other distribution with respect to, or in
exchange for or in replacement of the Series A Preferred Stock, Series B
Preferred Stock, Series C Preferred Stock, Series D Preferred Stock or the Mount
Sinai Shares; (d) any Common Stock acquired by any Investor or Mount Sinai
subsequent to the date hereof and (e) the Common Stock issuable upon the
exercise of the GECC Warrant. Notwithstanding the foregoing, as to any
particular Registrable Securities that have been issued, such securities shall
cease to be Registrable Securities when (i) a registration statement with
respect to the sale of such securities shall have become effective under the
Securities Act and such securities shall have been disposed of under such
registration statement, (ii) they shall have been distributed to the public
pursuant to Rule 144, (iii) they shall have been otherwise transferred or
disposed of, and new certificates therefor not bearing a legend restricting
further transfer shall have been delivered by the Company, and subsequent
transfer or disposition of them shall not require their registration or
qualification under the Securities Act or any similar state law then in force,
or (iv) they shall have ceased to be outstanding.

                                      -3-
<PAGE>

      "Registration Statement" means a registration statement filed by the
Company with the SEC for a public offering and sale of securities of the Company
(other than a registration statement on Form S-8 or Form S-4, or their
successors).

      "S-3 Initiating Holders" has the meaning set forth in Section 5(a) of this
Agreement.

      "S-3 Registration" has the meaning set forth in Section 5(a) of this
Agreement.

      "SEC" means the Securities and Exchange Commission or any similar agency
then administering the Securities Act.

      "Securities Act" means the Securities Act of 1933, as amended, and the
rules and regulations of the SEC promulgated thereunder.

      "Series A Preferred Stock" means the Series A Convertible Preferred Stock
of the Company, par value $0.01 per share.

      "Series B Preferred Stock" means the Series B Convertible Preferred Stock
of the Company, par value $0.01 per share.

      "Series C Preferred Stock" means the Series C Convertible Preferred Stock
of the Company, par value $0.01 per share.

      "Series D Preferred Stock" has the meaning set forth in the preamble to
this Agreement.

      "Series D Stock Purchase Agreement" has the meaning set forth in the
recitals to this Agreement.

      "Stockholders Agreement" means the Third Amended and Restated Stockholders
Agreement, dated the date hereof, as amended from time to time, among the
Company, the Investors, and the other stockholders named therein.

      2. Grant Of Rights. The Company hereby grants Registration Rights to the
Holders upon the terms and conditions set forth in this Agreement.

      3. Demand Registration.

            (a) Request for Demand Registration for Holders. At any time after
the 180-day period following the IPO Effectiveness Date, the Holders of a
majority of the Registrable Securities held in the aggregate by all Holders (the
"Initiating Holders"), may make a written request to the Company to register,
and the Company shall register, under the Securities Act (other than pursuant to
a Registration Statement on Form S-4 or S-8 or any successor thereto) (a "Demand
Registration"), the number of Registrable Securities stated in such request;
provided, however, that the Company shall not be obligated to effect (i) more
than two such Demand Registrations under this Section 3(a) and (ii) a Demand
Registration if the Initiating Holders propose to sell their Registrable
Securities at an aggregate price (calculated based upon the Market Price of the
Registrable Securities on the date of filing of the Registration Statement with
respect to such Registrable Securities) to the public of less than $5,000,000.
For purposes of the

                                      -4-
<PAGE>

preceding sentence, two or more Registration Statements filed in response to one
demand shall be counted as one Registration Statement. If at the time of any
request to register Registrable Securities pursuant to this Section 3(a), the
Company is engaged in a registered public offering or the Company determines in
good faith certifies in writing that any such registration would require the
Company to include disclosure that would reasonably be expected to have a
materially detrimental effect on any proposal, negotiations or plan by the
Company or any of its subsidiaries to engage in any material acquisition or
disposition of assets or any material merger, consolidation, tender offer,
reorganization or similar transaction or any other material corporate event
contemplated by the Company, then the Company may at its option direct that such
request be delayed for a reasonable period not in excess of three (3) months,
such right to delay a request to be exercised by the Company not more than once
in any twelve (12) month period. Each request for a Demand Registration by the
Initiating Holders shall state the amount of the Registrable Securities proposed
to be sold and the intended method of disposition thereof.

            (b) Incidental or "Piggy-Back" Rights with Respect to a Demand
Registration. Each of the Holders (other than Initiating Holders which have
requested a registration under Section 3(a)) may include its or his Registrable
Securities in any Demand Registration pursuant to this Section 3(b). Within ten
(10) days after the receipt of a request for a Demand Registration from an
Initiating Holder, the Company shall (i) give written notice thereof to all of
the Holders (other than Initiating Holders which have requested a registration
under Section 3(a)) and (ii) subject to Section 3(e), include in such
registration all of the Registrable Securities held by such Holders from whom
the Company has received a written request for inclusion therein within twenty
(20) days of the receipt by such Holders of such written notice referred to in
clause (i) above. Each such request by such Holders shall specify the number of
Registrable Securities proposed to be registered. The failure of any Holder to
respond within such 20-day period referred to in clause (ii) above shall be
deemed to be a waiver of such Holder's rights under this Section 3 with respect
to such Demand Registration, provided that any Holder may waive its rights under
this Section 3 prior to the expiration of such 20-day period by giving written
notice to the Company, with a copy to the Initiating Holders.

            (c) Effective Demand Registration. A registration shall not
constitute a Demand Registration until it has become effective and remains
continuously effective for the lesser of (i) the period during which all
Registrable Securities registered in the Demand Registration are sold and (ii)
120 days; provided, however, that a registration shall not constitute a Demand
Registration if (x) after such Demand Registration has become effective, such
registration or the related offer, sale or distribution of Registrable
Securities thereunder is interfered with by any stop order, injunction or other
order or requirement of the SEC or other governmental agency or court for any
reason not attributable to the Initiating Holders and such interference is not
thereafter eliminated or (y) the conditions specified in the underwriting
agreement, if any, entered into in connection with such Demand Registration are
not satisfied or waived, other than by reason of a failure by the Initiating
Holder.

            (d) Expenses. The Company shall pay all Registration Expenses in
connection with a Demand Registration, whether or not such Demand Registration
becomes effective.

                                      -5-
<PAGE>

            (e) Underwriting Procedures. If the Company or the Initiating
Holders holding a majority of the Registrable Securities held by all of the
Initiating Holders so elect, the Company shall use its reasonable best efforts
to cause such Demand Registration to be in the form of a firm commitment
underwritten offering and the managing underwriter or underwriters selected for
such offering shall be the Approved Underwriter selected in accordance with
Section 3(f). In connection with any Demand Registration under this Section 3
involving an underwritten offering, none of the Registrable Securities held by
any Holder making a request for inclusion of such Registrable Securities
pursuant to Section 3 hereof shall be included in such underwritten offering
unless such Holder accepts the terms of the offering as agreed upon by the
Company, the Initiating Holders and the Approved Underwriter, and then only in
such quantity as will not, in the opinion of the Approved Underwriter, have a
material adverse effect on the success of such offering by the Initiating
Holders. If the Approved Underwriter advises the Company that the aggregate
amount of such Registrable Securities requested to be included in such offering
is sufficiently large to have a material adverse effect on the success of such
offering, then the Company shall include in such registration only the aggregate
amount of Registrable Securities that the Approved Underwriter believes may be
sold without any such material adverse effect and shall reduce the amount of
Registrable Securities to be included in such registration by removing
Registrable Securities owned, first by the Company, second by the entities
listed on Schedule II hereto, Mount Sinai and GECC, pro rata based on the number
of Registrable Securities owned by each such Person and third by all other
Holders, pro rata based on the number of Registrable Securities owned by each
such Holder.

            (f) Selection of Underwriters. If any Demand Registration or S-3
Registration, as the case may be, of Registrable Securities is in the form of an
underwritten offering, the Company shall select and obtain an investment banking
firm of national reputation to act as the managing underwriter of the offering
(the "Approved Underwriter"); provided, however, that the Approved Underwriter
shall, in any case, also be approved by the Initiating Holders or S-3 Initiating
Holders, as the case may be, such approval not to be unreasonably withheld.

      4. Incidental or "Piggy-Back" Registration.

            (a) Request for Incidental Registration. At any time after the IPO
Effectiveness Date, if the Company proposes to file a Registration Statement
under the Securities Act with respect to an offering by the Company for its own
account (other than a Registration Statement on Form S-4 or S-8 or any successor
thereto) or for the account of any stockholder of the Company other than the
Initiating Holders pursuant to a Demand Registration, then the Company shall
give written notice of such proposed filing to each of the Holders at least
twenty (20) days before the anticipated filing date, and such notice shall
describe the proposed registration and distribution and offer such Holders the
opportunity to register the number of Registrable Securities as each such Holder
may request (an "Incidental Registration"). The Company shall use its reasonable
best efforts (within ten (10) days of the notice provided for in the preceding
sentence) to cause the managing underwriter or underwriters in the case of a
proposed underwritten offering (the "Company Underwriter") to permit each of the
Holders who have requested in writing to participate in the Incidental
Registration to include its or his Registrable Securities in such offering on
the same terms and conditions as the securities of the Company or the account of
such other stockholder, as the case may be, included therein. In

                                      -6-
<PAGE>

connection with any Incidental Registration under this Section 4(a) involving an
underwritten offering, the Company shall not be required to include any
Registrable Securities in such underwritten offering unless the Holders thereof
accept the terms of the underwritten offering as agreed upon between the
Company, such other stockholders, if any, and the Company Underwriter, and then
only in such quantity as the Company Underwriter believes will not have a
material adverse effect on the success of such offering. If the Company
Underwriter determines that the registration of all or part of the Registrable
Securities which the Holders have requested to be included would have a material
adverse effect on the success of such offering, then the Company shall be
required to include in such Incidental Registration, to the extent of the amount
that the Company Underwriter believes may be sold without causing such adverse
effect, first, all of the securities to be offered for the account of the
Company or the account of any other stockholder at the request of which the
Company intends to file a Registration Statement, as the case may be; second,
the Registrable Securities to be offered for the account of the Holders, pro
rata based on the number of Registrable Securities owned by each such Holder;
and third, any other securities requested to be included in such underwritten
offering.

            (b) Expenses. The Company shall bear all Registration Expenses in
connection with any Incidental Registration pursuant to this Section 4, whether
or not such Incidental Registration becomes effective.

      5. Form S-3 Registration.

            (a) Request for a Form S-3 Registration. Upon the Company becoming
eligible for use of Form S-3 (or any successor form thereto) under the
Securities Act in connection with a public resale of its securities, in the
event that the Company shall receive from one or more of the Holders (the "S-3
Initiating Holders"), a written request that the Company register, under the
Securities Act on Form S-3 (or any successor form then in effect) (an "S-3
Registration"), all or a portion of the Registrable Securities owned by such S-3
Initiating Holders, the Company shall give written notice of such request to all
of the Holders (other than S-3 Initiating Holders which have requested an S-3
Registration under this Section 5(a)) at least thirty (30) days before the
anticipated filing date of such Form S-3, and such notice shall describe the
proposed registration and offer such Holders the opportunity to register the
number of Registrable Securities as each such Holder may request in writing to
the Company, given within fifteen (15) days after their receipt from the Company
of the written notice of such registration. With respect to each S-3
Registration, the Company shall, subject to Section 5(b), (i) include in such
offering the Registrable Securities of the S-3 Initiating Holders and (ii)
include in such offering the Registrable Securities of the Holders (other than
S-3 Initiating Holders which have requested an S-3 Registration under this
Section 5(a)) who have requested in writing to participate in such registration
on the same terms and conditions as the Registrable Securities of the S-3
Initiating Holders included therein.

            (b) Limitations on Form S-3 Registrations. If at the time of any
request to register Registrable Securities pursuant to Section 5(a), the Company
is engaged in a registered public offering or if the Company shall in good faith
certify in writing that any such registration would require the Company to
include disclosure that would reasonably be expected to have a materially
detrimental effect on any proposal, negotiations or plan by the Company or any
of its subsidiaries to engage in any material acquisition or disposition of
assets or any material merger,

                                      -7-
<PAGE>

consolidation, tender offer, reorganization or similar transaction or any other
material corporate event contemplated by the Company, then the Company may at
its option direct that such request be delayed for a reasonable period not in
excess of three (3) months, such right to delay a request to be exercised by the
Company not more than once in any twelve (12) month period. In addition, the
Company shall not be required to effect any registration pursuant to Section
5(a), (i) within ninety (90) days after the effective date of any other
Registration Statement of the Company, (ii) if within the twelve (12) month
period preceding the date of such request, the Company has effected two (2)
registrations on Form S-3 pursuant to Section 5(a), (iii) if Form S-3 is not
available for such offering by the S-3 Initiating Holders or (iv) if the S-3
Initiating Holders, together with the Holders (other than S-3 Initiating Holders
which have requested an S-3 Registration under Section 5(a)) registering
Registrable Securities in such registration, propose to sell their Registrable
Securities at an aggregate price (calculated based upon the Market Price of the
Registrable Securities on the date of filing of the Form S-3 with respect to
such Registrable Securities) to the public of less than $2,500,000.

            (c) Expenses. The Company shall bear all Registration Expenses in
connection with any S-3 Registration pursuant to this Section 5, whether or not
such S-3 Registration becomes effective.

            (d) No Demand Registration. No registration requested by any Holder
pursuant to this Section 5 shall be deemed a Demand Registration pursuant to
Section 3.

      6. Holdback Agreements.

            (a) Restrictions on Public Sale by Holders. In connection with any
public offering, each Holder, if requested by the Company and the underwriters
managing such public offering, shall agree not to sell or otherwise transfer or
dispose of any Registrable Securities or other securities of the Company held by
such Holder (other than those Registrable Securities, if any, included in the
public offering) for a specified period of time determined by the Company and
the underwriters following the effective date of a Registration Statement;
provided, however, that: (i) such agreement shall not exceed 180 days from the
effective date of such registration; (ii) all holders of Common Stock holding
not less than the number of shares of Common Stock held by such Holder
(including shares of Common Stock issuable upon the conversion of Series A
Preferred Stock, Series B Preferred Stock, Series C Preferred Stock, Series D
Preferred Stock or other convertible or exchangeable securities, or upon the
exercise of options, warrants or other rights) and all officers and directors of
the Company enter into similar agreements; provided, however, that all
restrictions set forth in this Section 6 on all such Holders shall terminate and
be of no further force or effect if any such holder, officer, other Holder, or
director is released from, or otherwise no longer bound by, such restrictions;
and (iii) such agreement shall only apply to the first such Registration
Statement covering Common Stock of the Company to be sold on its behalf to the
public in the Initial Public Offering.

            (b) Legend. Each certificate representing the Registrable Securities
shall bear a legend substantially in the following form (until such time as such
Registrable Securities cease to be Registrable Securities as set forth herein):

            "THE SECURITIES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT

                                      -8-
<PAGE>

TO THE TERMS OF AN INVESTOR RIGHTS AGREEMENT BETWEEN THE COMPANY AND THE
REGISTERED OWNER OF THIS CERTIFICATE (OR THE REGISTERED OWNER'S PREDECESSOR IN
INTEREST), AND SUCH AGREEMENT IS AVAILABLE FOR INSPECTION WITHOUT CHARGE AT THE
OFFICES OF THE COMPANY."

      7. Registration Procedures.

            (a) Obligations of the Company. Whenever registration of Registrable
Securities has been requested pursuant to Section 3 or Section 5 of this
Agreement, the Company shall use its reasonable best efforts to cause any such
registration to become and remain effective as soon as practicable, but in any
event not later than forty-five (45) days after it receives a request
thereunder, and whenever registration of Registrable Securities has been
requested pursuant to Section 5 of this Agreement, the Company shall use its
reasonable best efforts to effect the registration and sale of such Registrable
Securities in accordance with the intended method of distribution thereof as
quickly as practicable, and in connection with any such request under Section 3,
Section 4 or Section 5 of this Agreement, the Company shall, as expeditiously as
possible:

                  (i) prepare and file with the SEC a Registration Statement on
any form for which the Company then qualifies or which counsel for the Company
shall deem appropriate and which form shall be available for the sale of such
Registrable Securities in accordance with the intended method of distribution
thereof, and cause such Registration Statement to become effective; provided,
however, that (x) before filing a Registration Statement or prospectus or any
amendments or supplements thereto, the Company shall provide one counsel
selected by the Holders holding a majority of the Registrable Securities being
registered in such registration ("Holders' Counsel") with an adequate and
appropriate opportunity to review and comment on such Registration Statement and
each prospectus included therein (and each amendment or supplement thereto) to
be filed with the SEC, subject to such documents being under the Company's
control, and (y) the Company shall notify the Holders' Counsel and each seller
of Registrable Securities of any stop order issued or threatened by the SEC and
take all action required to prevent the entry of such stop order or to remove it
if entered;

                  (ii) prepare and file with the SEC such amendments and
supplements to such Registration Statement and the prospectus used in connection
therewith as may be necessary to keep such Registration Statement effective for
the lesser of (x) 120 days and (y) such shorter period which will terminate when
all Registrable Securities covered by such Registration Statement have been
sold, and comply with the provisions of the Securities Act with respect to the
disposition of all securities covered by such Registration Statement during such
period in accordance with the intended methods of disposition by the sellers
thereof set forth in such Registration Statement;

                  (iii) furnish to each seller of Registrable Securities, prior
to filing a Registration Statement, at least one copy of such Registration
Statement as is proposed to be filed, and thereafter such number of copies of
such Registration Statement, each amendment and supplement thereto (in each case
including all exhibits thereto), and the prospectus included in such
Registration Statement (including each preliminary prospectus) as each such
seller may

                                      -9-
<PAGE>

reasonably request in order to facilitate the disposition of the Registrable
Securities owned by such seller;

                  (iv) register or qualify such Registrable Securities under
such other securities or "blue sky" laws of such jurisdictions as any seller of
Registrable Securities may request, and to continue such qualification in effect
in such jurisdiction for as long as permissible pursuant to the laws of such
jurisdiction, or for as long as any such seller requests or until all of such
Registrable Securities are sold, whichever is shortest, and do any and all other
acts and things which may be reasonably necessary or advisable to enable any
such seller to consummate the disposition in such jurisdictions of the
Registrable Securities owned by such seller; provided, however, that the Company
shall not be required to (x) qualify generally to do business in any
jurisdiction where it would not otherwise be required to qualify but for this
Section 7(a)(iv), (y) subject itself to taxation in any such jurisdiction or (z)
consent to general service of process in any such jurisdiction;

                  (v) notify each seller of Registrable Securities at any time
when a prospectus relating thereto is required to be delivered under the
Securities Act, upon discovery that, or upon the happening of any event as a
result of which, the prospectus included in such Registration Statement contains
an untrue statement of a material fact or omits to state any material fact
required to be stated therein or necessary to make the statements therein, in
light of the circumstances under which they were made, not misleading and the
Company shall promptly prepare a supplement or amendment to such prospectus and
furnish to each seller of Registrable Securities a reasonable number of copies
of such supplement to or an amendment of such prospectus as may be necessary so
that, after delivery to the purchasers of such Registrable Securities, such
prospectus shall not contain an untrue statement of a material fact or omit to
state any material fact required to be stated therein or necessary to make the
statements therein, in light of the circumstances under which they were made,
not misleading;

                  (vi) enter into and perform customary agreements (including an
underwriting agreement in customary form with the Approved Underwriter or
Company Underwriter, if any, selected as provided in Section 3, Section 4 or
Section 5, as the case may be) and take such other actions as are prudent and
reasonably required in order to expedite or facilitate the disposition of such
Registrable Securities, including causing its officers to participate in "road
shows" and other information meetings organized by the Approved Underwriter or
Company Underwriter;

                  (vii) provide a transfer agent and registrar for all
Registrable Securities registered pursuant to this Agreement and CUSIP number
for all such Registrable Securities, in each case not later than the effective
date of such registration;

                  (viii) make available at reasonable times for inspection by
any seller of Registrable Securities, any managing underwriter participating in
any disposition of such Registrable Securities pursuant to a Registration
Statement, Holders' Counsel and any attorney, accountant or other agent retained
by any such seller or any managing underwriter (each, an "Inspector" and
collectively, the "Inspectors"), all financial and other records, pertinent
corporate documents and properties of the Company and its subsidiaries as shall
be reasonably necessary to enable them to exercise their due diligence
responsibility, and cause the Company's

                                      -10-
<PAGE>

and its subsidiaries' officers, directors and employees, and the independent
public accountants of the Company, to supply all information reasonably
requested by any such Inspector in connection with such Registration Statement;

                  (ix) if such sale is pursuant to an underwritten offering,
obtain a "cold comfort" letter from the Company's independent public accountants
in customary form and covering such matters of the type customarily covered by
"cold comfort" letters as Holders' Counsel or the managing underwriter
reasonably requests;

                  (x) furnish, at the request of any seller of Registrable
Securities on the date such securities are delivered to the underwriters for
sale pursuant to such registration or, if such securities are not being sold
through underwriters, on the date the Registration Statement with respect to
such securities becomes effective, an opinion, dated such date, of counsel
representing the Company for the purposes of such registration, addressed to the
underwriters, if any, and to the seller making such request, covering such legal
matters with respect to the registration in respect of which such opinion is
being given as the underwriters, if any, and such seller may reasonably request
and are customarily included in such opinions;

                  (xi) comply with all applicable rules and regulations of the
SEC, and make available to its security holders, as soon as reasonably
practicable but no later than fifteen (15) months after the effective date of
the Registration Statement, an earnings statement covering a period of twelve
(12) months beginning after the effective date of the Registration Statement, in
a manner which satisfies the provisions of Section 11(a) of the Securities Act
and Rule 158 thereunder;

                  (xii) cause all such Registrable Securities to be listed on
each securities exchange on which similar securities issued by the Company are
then listed, provided that the applicable listing requirements are satisfied;

                  (xiii) keep Holders' Counsel advised in writing as to the
initiation and progress of any registration under Section 3, Section 4 or
Section 5 hereunder;

                  (xiv) cooperate with each seller of Registrable Securities and
each underwriter participating in the disposition of such Registrable Securities
and their respective counsel in connection with any filings required to be made
with the NASD; and

                  (xv) take all other steps reasonably necessary to effect the
registration of the Registrable Securities contemplated hereby.

            (b) Seller Information. The Company may require each seller of
Registrable Securities as to which any registration is being effected to
furnish, and such seller shall furnish, to the Company such information
regarding such seller and the distribution of such securities as the Company may
from time to time reasonably request in writing.

            (c) Notice to Discontinue. Each Holder of Registrable Securities
agrees that, upon receipt of any notice from the Company of the happening of any
event of the kind described in Section 7(a)(v), such Holder shall forthwith
discontinue disposition of Registrable Securities pursuant to the Registration
Statement covering such Registrable Securities until such

                                      -11-
<PAGE>

Holder's receipt of the copies of the supplemented or amended prospectus
contemplated by Section 7(a)(v) and, if so directed by the Company, such Holder
shall deliver to the Company (at the Company's expense) all copies, other than
permanent file copies then in such Holder's possession, of the prospectus
covering such Registrable Securities which is current at the time of receipt of
such notice. If the Company shall give any such notice, the Company shall extend
the period during which such Registration Statement shall be maintained
effective pursuant to this Agreement (including, without limitation, the period
referred to in Section 7(a)(ii)) by the number of days during the period from
and including the date of the giving of such notice pursuant to Section 7(a)(v)
to and including the date when sellers of such Registrable Securities under such
Registration Statement shall have received the copies of the supplemented or
amended prospectus contemplated by and meeting the requirements of Section
7(a)(v).

            (d) Registration Expenses. The Company shall pay all expenses
arising from or incident to its performance of, or compliance with, this
Agreement, including, without limitation, (i) SEC, stock exchange and NASD
registration and filing fees, (ii) all fees and expenses incurred in complying
with securities or "blue sky" laws (including reasonable fees, charges and
disbursements of counsel to any underwriter incurred in connection with "blue
sky" qualifications of the Registrable Securities as may be set forth in any
underwriting agreement), (iii) all printing, messenger and delivery expenses,
(iv) the fees, charges and disbursements of counsel to the Company and of its
independent public accountants and any other accounting fees, charges and
expenses incurred by the Company (including, without limitation, any expenses
arising from any "cold comfort" letters or any special audits incident to or
required by any registration or qualification) and any legal fees, charges and
expenses incurred by the Company and, in the case of a Demand Registration, an
Incidental Registration or an S-3 Registration, the Holders' Counsel, and (v)
any liability insurance or other premiums for insurance obtained in connection
with any Demand Registration or piggy-back registration thereon, Incidental
Registration or S-3 Registration pursuant to the terms of this Agreement,
regardless of whether such Registration Statement is declared effective.
Notwithstanding the foregoing, the Company shall not be obligated to pay the
fees, expenses or charges of any Inspector other than Holders' Counsel. All of
the expenses described in the preceding sentence of this Section 7(d) are
referred to herein as "Registration Expenses." The Holders of Registrable
Securities sold pursuant to a Registration Statement shall bear the expense of
any broker's commission or underwriter's discount or commission relating to
registration and sale of such Holders' Registrable Securities and, subject to
clause (iv) above, shall bear the fees and expenses of their own counsel.

      8. Indemnification; Contribution.

            (a) Indemnification by the Company. The Company agrees to indemnify
and hold harmless each Holder (including each member, partner, officer and
director thereof and legal counsel and independent accountant thereto) and each
Person who or that controls (within the meaning of the Securities Act or the
Exchange Act) such Holder from and against any and all losses, claims, damages,
liabilities and expenses, joint or several (including reasonable costs of
investigation and including any of the foregoing incurred in connection with the
settlement of any commenced or threatened litigation) (collectively,
"Liabilities"), arising out of or based upon any untrue, or allegedly untrue,
statement of a material fact contained in any Registration Statement, prospectus
or preliminary prospectus or notification or offering circular (as amended

                                      -12-
<PAGE>

or supplemented if the Company shall have furnished any amendments or
supplements thereto) or arising out of or based upon any omission or alleged
omission to state therein a material fact required to be stated therein or
necessary to make the statements therein not misleading under the circumstances
such statements were made or any violation or alleged violation by the Company
of the Securities Act, the Exchange Act, any state securities law or any rule or
regulation promulgated under the Securities Act, the Exchange Act or any state
securities laws or otherwise in connection with the offering covered by such
Registration Statement, except insofar as such Liability arises out of or is
based upon any untrue statement or alleged untrue statement or omission or
alleged omission contained in such Registration Statement, preliminary
prospectus or final prospectus in reliance upon information concerning such
Holder furnished in writing to the Company by such Holder expressly for use
therein, including, without limitation, the information furnished to the Company
pursuant to Section 7(b). The Company shall also provide customary indemnities
to any underwriters of the Registrable Securities, their officers, directors and
employees and each Person who controls such underwriters (within the meaning of
Section 15 of the Securities Act) to the same extent as provided above with
respect to the indemnification of the Holders of Registrable Securities.

            (b) Indemnification by Holders. In connection with any Registration
Statement in which a Holder is participating pursuant to Section 3, Section 4 or
Section 5 hereof, each such Holder shall promptly furnish to the Company in
writing such information with respect to such Holder as the Company may
reasonably request or as may be required by law for use in connection with any
such Registration Statement or prospectus and all information required to be
disclosed in order to make the information previously furnished to the Company
by such Holder not materially misleading or necessary to cause such Registration
Statement not to omit a material fact with respect to such Holder necessary in
order to make the statements therein not misleading. Each Holder, severally and
not jointly, agrees to indemnify and hold harmless the Company, the
underwriters, if any, each other Holder, each Person who controls the Company,
any such underwriter or such other Holder (within the meaning of Section 15 of
the Securities Act) and their respective officers, directors, partners,
employees, agents and representatives for any Liabilities arising out of or
based upon any such information with respect to such Holder furnished in writing
to the Company by such Holder expressly for use in such registration statement
or prospectus, including, without limitation, the information furnished to the
Company pursuant to this Section 8(b) in the event that such information is an
untrue statement of material fact or omits a material fact required to be stated
therein or necessary to make such information not misleading under the
circumstances; provided, however, that the total amount to be indemnified by
such Holder pursuant to this Section 8(b) shall be limited to the net proceeds
received by such Holder in the offering to which the Registration Statement or
prospectus relates; provided, further, however, that no such Holder will be
liable for any amount paid in settlement of any such claim, loss, damage,
liability or action if such settlement is effected without the consent of such
Holder, which consent shall not be unreasonably withheld, conditioned or
delayed.

            (c) Conduct of Indemnification Proceedings. Any Person entitled to
indemnification hereunder (the "Indemnified Party") agrees to give prompt
written notice to the indemnifying party (the "Indemnifying Party") after the
receipt by the Indemnified Party of any written notice of the commencement of
any action, suit, proceeding or investigation or threat thereof made in writing
for which the Indemnified Party intends to claim indemnification or

                                      -13-
<PAGE>

contribution pursuant to this Agreement; provided, however, that the failure so
to notify the Indemnifying Party shall not relieve the Indemnifying Party of any
Liability that it may have to the Indemnified Party hereunder (except to the
extent that the Indemnifying Party is materially prejudiced or otherwise
forfeits material rights or defenses by reason of such failure). If notice of
commencement of any such action is given to the Indemnifying Party as above
provided, the Indemnifying Party shall be entitled to participate in and, to the
extent it may wish, jointly with any other Indemnifying Party similarly
notified, to assume the defense of such action at its own expense, with counsel
chosen by it and reasonably satisfactory to such Indemnified Party. The
Indemnified Party shall have the right to employ separate counsel in any such
action and participate in the defense thereof, but the fees and expenses of such
counsel shall be paid by the Indemnified Party unless (i) the Indemnifying Party
agrees to pay the same, (ii) the Indemnifying Party fails to assume the defense
of such action with counsel reasonably satisfactory to the Indemnified Party or
(iii) the named parties to any such action (including any impleaded parties)
include both the Indemnifying Party and the Indemnified Party and either of such
parties has been advised by its counsel that either (x) representation of such
Indemnified Party and the Indemnifying Party by the same counsel would be
inappropriate under applicable standards of professional conduct or (y) there
may be one or more legal defenses available to the Indemnified Party which are
different from or additional to those available to the Indemnifying Party. In
any such case, the Indemnifying Party shall not have the right to assume the
defense of such action on behalf of such Indemnified Party, it being understood,
however, that the Indemnifying Party shall not be liable for the fees and
expenses of more than one separate firm of attorneys (in addition to any local
counsel) for all similarly situated Indemnified Parties. No Indemnifying Party
shall be liable for any settlement entered into without its written consent,
which consent shall not be unreasonably withheld. No Indemnifying Party shall,
without the consent of such Indemnified Party, effect any settlement of or
consent to the entry of any judgment of any pending or threatened proceeding in
respect of which such Indemnified Party is a party and indemnity has been sought
hereunder by such Indemnified Party, unless such settlement includes an
unconditional release of such Indemnified Party from all liability for claims
that are the subject matter of such proceeding.

            (d) Contribution. If the indemnification provided for in this
Section 8 from the Indemnifying Party is unavailable to an Indemnified Party
hereunder in respect of any Liabilities referred to therein, then the
Indemnifying Party, in lieu of indemnifying such Indemnified Party, shall
contribute to the amount paid or payable by such Indemnified Party as a result
of such Liabilities in such proportion as is appropriate to reflect the relative
fault of the Indemnifying Party and Indemnified Party in connection with the
actions which resulted in such Liabilities, as well as any other relevant
equitable considerations. The relative faults of such Indemnifying Party and
Indemnified Party shall be determined by reference to, among other things,
whether any action in question, including any untrue or alleged untrue statement
of a material fact or omission or alleged omission to state a material fact, has
been made by, or relates to information supplied by, such Indemnifying Party or
Indemnified Party, and the parties' relative intent, knowledge, access to
information and opportunity to correct or prevent such action. The amount paid
or payable by a party as a result of the Liabilities referred to above shall be
deemed to include, subject to the limitations set forth in Sections 8(a), 8(b)
and 8(c), any legal or other fees, charges or expenses reasonably incurred by
such party in connection with any investigation or proceeding; provided that the
total amount to be contributed by any Holder shall be limited to the net
proceeds received by such Holder in the offering.

                                      -14-
<PAGE>

The parties hereto agree that it would not be just and equitable if contribution
pursuant to this Section 8(d) were determined by pro rata allocation or by any
other method of allocation which does not take account of the equitable
considerations referred to in the immediately preceding paragraph. No Person
guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of
the Securities Act) shall be entitled to contribution from any Person who was
not guilty of such fraudulent misrepresentation.

      9. Rule 144. The Company covenants that from and after the earliest of (a)
the IPO Effectiveness Date, (b) the registration by the Company of a class of
securities under Section 12 of the Exchange Act and (c) the issuance by the
Company of an offering circular pursuant to Regulation A under the Securities
Act it shall (i) file any reports required to be filed by it under the Exchange
Act and the Securities Act and (ii) take such further action as each Holder of
Registrable Securities may reasonably request (including providing any
information necessary to comply with Rule 144 under the Securities Act), all to
the extent required from time to time to enable such Holder to sell Registrable
Securities without registration under the Securities Act within the limitation
of the exemptions provided by (A) Rule 144 under the Securities Act, as such
rule may be amended from time to time or (B) any similar rules or regulations
hereafter adopted by the SEC. The Company shall, upon the request of any Holder
of Registrable Securities, deliver to such Holder (i) a written statement as to
whether it has complied with such requirements, (ii) a copy of the most recent
annual or quarterly report of the Company and such other reports and documents
so filed by the Company and (iii) such other information as may be reasonably
requested to avail any Holder of any rule or regulation of the SEC that permits
the selling of any such securities without registration or pursuant to such
form.

      10. Limitations on Subsequent Registration Rights; No Inconsistent
Agreements.

                  (i) The Company shall not, without the prior written consent
of the Investors holding at least a majority of the Registrable Securities held
by all Investors, enter into any other agreement with any holder or prospective
holder of any securities of the Company that would allow such holder or
prospective holder (a) to make a demand registration that could result in such
registration statement being declared effective prior to twelve (12) months
after the Initial Public Offering or (b) to have registration rights that are
pari passu with or superior to the rights granted to the Investors under this
Agreement. The Company represents and warrants that it has not granted to any
Person the right to request or require the Company to register any securities
issued by the Company, other than the rights granted to the Holders herein.

                  (ii) The Company shall not enter into any agreement with
respect to its securities that is inconsistent with the rights granted to the
Holders in this Agreement or grant any additional registration rights to any
Person or with respect to any securities which are not Registrable Securities
which are prior in right to or inconsistent with the rights granted in this
Agreement.

      11. Miscellaneous.

            (a) Recapitalizations, Exchanges, Etc. The provisions of this
Agreement shall apply to the full extent set forth herein with respect to (i)
the shares of Common Stock, (ii) any and all shares of voting common stock of
the Company into which the shares of Common Stock are converted, exchanged or
substituted in any recapitalization or other capital reorganization by

                                      -15-
<PAGE>

the Company and (iii) any and all equity securities of the Company or any
successor or assign of the Company (whether by merger, consolidation, sale of
assets or otherwise) which may be issued in respect of, in conversion of, in
exchange for or in substitution of, the shares of Common Stock and shall be
appropriately adjusted for any stock dividends, splits, reverse splits,
combinations, recapitalizations and the like occurring after the date hereof.
The Company shall cause any successor or assign (whether by merger,
consolidation, sale of assets or otherwise) to enter into an agreement with the
Holders on terms substantially the same as this Agreement as a condition of any
such transaction.

            (b) Remedies. The Holders, in addition to being entitled to exercise
all rights granted by law, including recovery of damages, shall be entitled to
specific performance of their rights under this Agreement. The Company agrees
that monetary damages would not be adequate compensation for any loss incurred
by reason of a breach by it of the provisions of this Agreement and hereby
agrees to waive in any action for specific performance the defense that a remedy
at law would be adequate.

            (c) Amendments and Waivers. Except as otherwise provided herein, the
provisions of this Agreement may not be amended, modified or supplemented, and
waivers or consents to departures from the provisions hereof may not be given
unless consented to in writing by (i) the Company and (ii) the Investors holding
at least a majority of the aggregate number of shares of Common Stock issued or
issuable upon conversion of the Series A Preferred Stock, the Series B Preferred
Stock, the Series C Preferred Stock and the Series D Preferred Stock owned by
all of the Investors; provided that no such amendment, supplement, modification,
waiver or consent shall affect an Investor disproportionately and adversely to
any other Investor without the consent of such other Investor. Any such written
consent shall be binding upon the Company and all of the Holders.

            (d) Notices. All notices, demands and other communications provided
for or permitted hereunder shall be made in writing and shall be made by
registered or certified first-class mail, return receipt requested, facsimile,
courier service or personal delivery:

                  (i) if to the Company:

                        Amicus Therapeutics,  Inc.
                        6 Cedar Brook Drive
                        Cranbury, NJ 08512
                        Facsimile:  (609) 662-2004
                        Attention:  Chief Executive Officer

                  with a copy to:

                        Bingham McCutchen LLP
                        150 Federal Street
                        Boston, MA 02110-1726
                        Facsimile: 617-951-8736
                        Attention:  Julio E. Vega, Esq.

                                      -16-
<PAGE>

                  (ii) if to any Holder, at its address as it appears on the
record books of the Company.

All such notices, demands and other communications shall be deemed to have been
duly given when delivered by hand, if personally delivered; when delivered by
courier, if delivered by commercial courier service; five (5) Business Days
after being deposited in the mail, postage prepaid, if mailed; and when receipt
is mechanically acknowledged, if sent by facsimile.

            (e) Successors and Assigns; Third Party Beneficiaries. This
Agreement shall inure to the benefit of and be binding upon the heirs, legatees,
legal representatives, successors and permitted assigns of each of the parties
hereto as hereinafter provided. The rights of the Holders set forth in this
Agreement shall be, with respect to any Registrable Security, automatically
transferred to any Person who is the transferee of such Registrable Security.
All of the obligations of the Company hereunder shall survive any such transfer.
Except as provided in Section 8, no Person other than the parties hereto and
their heirs, legatees, legal representatives, successors and permitted assigns
is intended to be a beneficiary of any of the rights granted hereunder.

            (f) Counterparts. This Agreement may be executed in any number of
counterparts and by the parties hereto in separate counterparts, including by
facsimile transmission, each of which when so executed shall be deemed to be an
original and all of which taken together shall constitute one and the same
agreement.

            (g) Headings. The headings in this Agreement are for convenience of
reference only and shall not limit or otherwise affect the meaning hereof.

            (h) Governing Law. THIS AGREEMENT SHALL BE GOVERNED BY AND CONSTRUED
IN ACCORDANCE WITH THE LAWS OF THE STATE OF DELAWARE, WITHOUT REGARD TO THE
PRINCIPLES OF CONFLICTS OF LAW OF ANY JURISDICTION.

            (i) Severability. If any one or more of the provisions contained
herein, or the application thereof in any circumstance, is held invalid, illegal
or unenforceable in any respect for any reason, the validity, legality and
enforceability of any such provision in every other respect and of the remaining
provisions hereof shall not be in any way impaired, it being intended that all
of the rights and privileges of the Holders shall be enforceable to the fullest
extent permitted by law.

            (j) Entire Agreement. This Agreement is intended by the parties as a
final expression of their agreement and intended to be a complete and exclusive
statement of the agreement and understanding of the parties hereto in respect of
the subject matter contained herein. There are no restrictions, promises,
warranties or undertakings, other than those set forth or referred to herein and
in the Series D Stock Purchase Agreement and the Stockholders Agreement. This
Agreement supersedes all prior agreements, understandings, or commitments,
whether oral or written, regarding the subject matter of this Agreement,
including without limitation, the Existing Investor Rights Agreement.

                                      -17-
<PAGE>

            (k) Further Assurances. Each of the parties shall execute such
documents and perform such further acts as may be reasonably required or
necessary to carry out or to perform the provisions of this Agreement.

            (l) Other Agreements. Nothing contained in this Agreement shall be
deemed to be a waiver of, or release from, any obligations any party hereto may
have under, or any restrictions on the transfer of Registrable Securities or
other securities of the Company imposed by, any other agreement including, but
not limited to, the Series D Stock Purchase Agreement or the Stockholders
Agreement.

            (m) Jury Trial Waiver. To the fullest extent permitted by law, and
as separately bargained-for-consideration, each party hereby waives any right to
trial by jury in any action, suit, proceeding or counterclaim of any kind
arising out of or relating to this Agreement.

            (n) Expenses. The Company shall pay, and hold the Investors and all
holders of Registrable Securities harmless against liability for the payment of
the reasonable fees and expenses incurred with respect to the enforcement of the
rights granted under this Agreement.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

                                      -18-
<PAGE>

                   SIGNATURE PAGE TO AMICUS THERAPEUTICS, INC.
                            INVESTOR RIGHTS AGREEMENT

      IN WITNESS WHEREOF, the parties have executed this Agreement as of the
date first above written.

                                       AMICUS THERAPEUTICS, INC.

                                       /s/ Donald J. Hayden, Jr.
                                       -----------------------------------------
                                       Donald J. Hayden, Jr.
                                       Chief Executive Officer

                                       Address: 6 Cedar Brook Drive
                                                Cranbury, New Jersey 08512

<PAGE>

                   SIGNATURE PAGE TO AMICUS THERAPEUTICS, INC.
                            INVESTOR RIGHTS AGREEMENT

                                 STOCKHOLDERS:

                                 NEW ENTERPRISE ASSOCIATES 11,
                                 LIMITED PARTNERSHIP

                                 By: NEA Partners 11, Limited Partnership,
                                 its general partner

                                 By: NEA 11 GP, LLC, its general partner

                                 By: /s/ illegible             , manager
                                     --------------------------

                                 NEW ENTERPRISE ASSOCIATES 9,
                                 LIMITED PARTNERSHIP

                                 By: NEA Partners 9, Limited Partnership

                                 By: /s/ illegible             , general partner
                                     --------------------------

                                 NEA VENTURES 2004, LIMITED
                                 PARTNERSHIP

                                 By: /s/ illegible             , vice-president
                                     --------------------------

<PAGE>

                   SIGNATURE PAGE TO AMICUS THERAPEUTICS, INC.
                            INVESTOR RIGHTS AGREEMENT

                                 STOCKHOLDERS:

                                 CANAAN EQUITY III, L.P.
                                 By:  Canaan Equity Partners III, L.P.
                                        Member

                                 By: /s/ Seth A. Rudnick
                                    ----------------------------
                                 Name:   Seth A. Rudnick
                                 Title:

                                 CANAAN EQUITY III ENTREPRENEURS, LLC
                                 By:  Canaan Equity Partners III, LLC
                                        Member

                                 By: /s/ Seth A. Rudnick
                                    ----------------------------
                                 Name:   Seth A. Rudnick
                                 Title:

                                 CHL MEDICAL PARTNERS II, L.P.
                                 By:  Collinson, Howe & Lennox II, LLC
                                 Its:   General Partner

                                 By: /s/ Gregory Weinhoff
                                    ----------------------------
                                 Name:   Gregory Weinhoff
                                 Title:  Vice President

                                 CHL MEDICAL PARTNERS II SIDE FUND,
                                 L.P.
                                 By:  Collinson, Howe & Lennox II, LLC
                                 Its:   General Partner

                                 By: /s/ Gregory Weinhoff
                                    ----------------------------
                                 Name:   Gregory Weinhoff
                                 Title:  Vice President

<PAGE>

                   SIGNATURE PAGE TO AMICUS THERAPEUTICS, INC.
                            INVESTOR RIGHTS AGREEMENT

                                 FRAZIER HEALTHCARE IV, L.P.
                                 By:  FHM IV, LP
                                 Its:   General Partner

                                 By: /s/ James Topper
                                    ----------------------------
                                 Name:  James Topper
                                 Title: Authorized Representative

                                 FRAZIER AFFILIATES IV, L.P.
                                 By:  FHM IV, LP
                                 Its:   General Partner

                                 By: /s/ James Topper
                                    ----------------------------
                                 Name:  James Topper
                                 Title: Authorized Representative

                                 PROSPECT VENTURE PARTNERS, II L.P.
                                 By:  Prospect Management Co., II, LLC
                                 Its:   General Partner

                                 By: /s/ Dave Markland
                                    ----------------------------
                                 Name:  Dave Markland
                                 Title: Attorney-in-Fact

                                 PROSPECT ASSOCIATES II, L.P.
                                 By:  Prospect Management Co., II, LLC
                                 Its:   General Partner

                                 By: /s/ Dave Markland
                                    ----------------------------
                                 Name:  Dave Markland
                                 Title: Authorized Representative

                                 RADIUS VENTURE PARTNERS II, L.P.
                                 By:  Radius Venture Partners II, LLC
                                 Its:   General Partner

                                 By: /s/ Jordan Davis
                                    ----------------------------
                                 Name:  Jordan Davis
                                 Title: Managing Member

<PAGE>

                   SIGNATURE PAGE TO AMICUS THERAPEUTICS, INC.
                            INVESTOR RIGHTS AGREEMENT

                                 HUTTON LIVING TRUST
                                 dated 12/10/96

                                 By: /s/ Wende S. Hutton
                                    ----------------------------
                                 Name:  Wende S. Hutton
                                 Title: Trustee

                                 QUAKER BIOVENTURES, L.P.
                                 By:  Quaker Bioventures Capital, L.P.,
                                 Its:   General Partner

                                 By:  Quaker Bioventures Capital, LLC.,
                                 Its:   General Partner

                                 By: /s/ Sherrill Neff
                                    ----------------------------
                                 Name:  Sherrill Neff
                                 Title: Member

                                 GARDEN STATE LIFE SCIENCES
                                 VENTURE FUND, L.P.
                                 By:  Quaker Bioventures Capital, L.P.,
                                 Its:   General Partner

                                 By:  Quaker Bioventures Capital, LLC.,
                                 Its:   General Partner

                                 By: /s/ Sherrill Neff
                                    ----------------------------
                                 Name:  Sherrill Neff
                                 Title: Member

<PAGE>

                   SIGNATURE PAGE TO AMICUS THERAPEUTICS, INC.
                            INVESTOR RIGHTS AGREEMENT

                                 PALO ALTO HEALTHCARE MASTER FUND, L.P.
                                 By:  Palo Alto Investors, LLC.,
                                 Its:   General Partner

                                 By:  Palo Alto Investors
                                 Its:   Manager

                                 By: /s/ illegible
                                    ----------------------------
                                 Name:
                                 Title:

                                 PALO ALTO FUND II, L.P.
                                 By:  Palo Alto Investors, LLC.,
                                 Its:   General Partner

                                 By:  Palo Alto Investors
                                 Its:   Manager

                                 By: /s/ illegible
                                    ----------------------------
                                 Name:
                                 Title:

                                 PALO ALTO HEALTHCARE FUND II, L.P.
                                 By:  Palo Alto Investors, LLC.,
                                 Its:   General Partner

                                 By:  Palo Alto Investors
                                 Its:   Manager

                                 By: /s/ illegible
                                    ----------------------------
                                 Name:
                                 Title:

<PAGE>

                   SIGNATURE PAGE TO AMICUS THERAPEUTICS, INC.
                            INVESTOR RIGHTS AGREEMENT

                                 OZ MASTER FUND, LTD.
                                 By:   OZ Management, L.L.C.,
                                 its Investment Manager

                                 By: /s/ Joel M. Frank
                                    ----------------------------
                                 Name: Joel M. Frank
                                 Title:  Chief Financial Officer

                                 OZ GLOBAL SPECIAL INVESTMENTS
                                 MASTER FUND, L.P.
                                 By: OZ Advisors, L.L.C., its General
                                 Partner
                                 By: Och-Ziff Associates, L.L.C., its
                                 Managing Member

                                 By: /s/ Joel M. Frank
                                    ----------------------------
                                 Name:  Joel M. Frank
                                 Title:  Chief Financial Officer

<PAGE>
                                   Schedule I
                                    Investors

Canaan Equity III L.P.

Canaan Equity III Entrepreneurs LLC

CHL Medical Partners II, L.P.

CHL Medical Partners II Side Fund, L.P.

Frazier Affiliates IV, L.P.

Frazier Healthcare IV, L.P.

Hutton Living Trust dated 12/10/96

New Enterprise Associates 11, Limited Partnership

New Enterprise Associates 9, Limited Partnership

OZ Master Fund, Ltd.

OZ Global Special Investments Master Fund, L.P.

Palo Alto Healthcare Master Fund

Palo Alto Healthcare Fund II

Palo Alto Fund II

Prospect Associates II, L.P.

Prospect Venture Partners II, L.P.

Radius Venture Partners II, L.P.

Quaker BioVentures, L.P.

Garden State Life Sciences Venture Fund, L.P.

<PAGE>

                                   Schedule II

Mount Sinai School of Medicine

General Electric Capital Corporation

<PAGE>
                                 AMENDMENT NO. 1

                                     TO THE

                           THIRD AMENDED AND RESTATED
                            INVESTOR RIGHTS AGREEMENT
                          DATED AS OF SEPTEMBER 13,2006

      THIS AMENDMENT NO. 1 (the "Amendment"), dated effective the 25th day of
October, 2006, to that certain Third Amended and Restated Investor Rights
Agreement dated as of September 13,2006 (the "Agreement"), by and among Amicus
Therapeutics, Inc., a Delaware corporation (the "Company"), the parties listed
on Schedule I thereto (the "Investors") and the parties listed on Schedule II
thereto. Unless otherwise defined herein, capitalized terms used but not defined
herein shall have the meaning set forth in the Agreement and the Agreement shall
be amended to incorporate any additional definitions provided for in this
Amendment, including definitions in the recitals hereto.

      WHEREAS, the undersigned Investors hold at least a majority of the
aggregate number of shares of Common Stock issued or issuable upon conversion of
the Series A Preferred Stock, the Series B Preferred Stock, the Series C
Preferred Stock and the Series D Preferred Stock owned by all Investors;

      WHEREAS, the Company desires to issue shares of Common Stock to Mount
Sinai pursuant to that certain Agreement to Amend License Agreement of even date
herewith, and the undersigned Investors desire to designate such shares as
"Mount Sinai Shares," as defined in the Agreement;

      NOW, THEREFORE, in consideration of the premises and the mutual agreements
hereinafter set forth, the parties hereby agree as follows:

            1. Amendment of Definition of "Mount Sinai Shares". The definition
of "Mount Sinai Shares" under Section 1 of the Agreement is hereby amended to
read in its entirety as follows:

                  "Mount Sinai Shares" means the following shares of Common
      Stock issued to and held by Mount Sinai: (a) the 1,742,000 shares issued
      to Mount Sinai on April 15, 2002; and (b) the 1,000,000 shares issued to
      Mount Sinai pursuant to that certain Agreement to Amend License Agreement
      dated October 25, 2006, by and between the Company and Mount Sinai.

            2. Extent of Amendment. Except as amended hereby, all provisions of
the Agreement shall remain in full force and effect.

            3. Counterparts. This Amendment may be executed in a number of
identical counterparts, each of which for all purposes is to be deemed an
original.

                            [SIGNATURE PAGE FOLLOWS]
<PAGE>

                    SIGNATURE PAGE TO AMICUS THERAPEUTICS,INC.
                   AMENDMENT NO. 1 TO INVESTOR RIGHTS AGREEMENT

      IN WITNESS WHEREOF, the parties have executed this Agreement as of the
date first above written.

                                       AMICUS THERAPEUTICS, INC.

                                       /s/ Donald J. Hayden
                                       -----------------------------------------
                                       Donald J. Hayden
                                       Interim President and
                                       Chief Executive Officer

                                       Address: 6 Cedar Brook Drive
                                                Cranbury, New Jersey 085 12

                                       STOCKHOLDERS:

                                       NEW ENTERPRISE ASSOCIATES 11,
                                       LIMITED PARTNERSHIP

                                       By: NEA Partners 11, Limited Partnership,
                                       its general partner

                                       By: NEA 11 GP, LLC, its general partner

                                       By: /s/ illegible       , general partner
                                           --------------------

                                       NEW ENTERPRISE ASSOCIATES 9,
                                       LIMITED PARTNERSHIP

                                       By: NEA Partners 9, Limited Partnership

                                       By: /s/ illegible       , general partner
                                           --------------------

                                       NEA VENTURES 2004, LIMITED PARTNERSHIP

                                       By: /s/ illegible        , vice-president
                                           ---------------------

<PAGE>

                   SIGNATURE PAGE TO AMICUS THERAPEUTICS,INC.
                   AMENDMENT NO. 1 TO INVESTOR RIGHTS AGREEMENT

                                       CANAAN EQUITY III, L.P.
                                       By: Canaan Equity Partners III L.P.
                                              Member

                                       By: /s/ Seth A. Rudnick
                                           -------------------------------------
                                       Name: Seth A. Rudnick
                                       Title:

                                       CANAAN EQUITY 111 ENTREPRENEURS, LLC
                                       By: Canaan Equity Partners III, LLC
                                              Member

                                       By: /s/ Seth A. Rudnick
                                           -------------------------------------
                                       Name: Seth A. Rudnick
                                       Title:

                                       CHL MEDICAL PARTNERS 11, L.P.
                                       By: Collinson, Howe & Lennox II, LLC
                                       Its:   General Partner

                                       By: /s/ Gregory Weinhoff
                                           -------------------------------------
                                       Name: Gregory Weinhoff
                                       Title: Vice President

                                       CHL MEDICAL PARTNERS II SIDE FUND, L.P.
                                       By: Collinson, Howe & Lennox II, LLC
                                       Its:   General Partner

                                       By: /s/ Gregory Weinhoff
                                           -------------------------------------
                                       Name: Gregory Weinhoff
                                       Title: Vice President

<PAGE>

                   SIGNATURE PAGE TO AMICUS THERAPEUTICS,INC.
                   AMENDMENT NO. 1 TO INVESTOR RIGHTS AGREEMENT

                                       FRAZIER HEALTHCARE IV, L.P.
                                       BY: FHM IV, LP
                                       ITS:    GENERAL PARTNER

                                       By: /s/ James Topper
                                           -------------------------------------
                                       Name: James Topper
                                       Title: General Partner

                                       FRAZIER AFFILIATES IV, L.P.
                                       BY: FHM IV, LP
                                       ITS:    GENERAL PARTNER

                                       By: /s/ James Topper
                                           -------------------------------------
                                       Name: James Topper
                                       Title: General Partner

                                       PROSPECT VENTURE PARTNERS, II L.P.
                                       BY: PROSPECT MANAGEMENT CO., II, LLC
                                       ITS:    GENERAL PARTNER

                                       By: /s/ Dave Markland
                                           -------------------------------------
                                       Name:   Dave Markland
                                       Title:  Attorney-in-Fact

                                       PROSPECT ASSOCIATES II, L.P.
                                       BY: PROSPECT MANAGEMENT CO., II, LLC
                                       ITS:    GENERAL PARTNER

                                       By: /s/ Dave Markland
                                           -------------------------------------
                                       Name:   Dave Markland
                                       Title:  Attorney-in-Fact

<PAGE>

                   SIGNATURE PAGE TO AMICUS THERAPEUTICS,INC.
                   AMENDMENT NO. 1 TO INVESTOR RIGHTS AGREEMENT

                                   QUAKER BIOVENTURES, L.P.
                                   By: Quaker Bioventures Capital, L.P.,
                                   Its:    General Partner

                                   By: Quaker Bioventures Capital, LLC.,
                                   Its:    General Partner

                                   By: /s/ Sherrill Neff
                                       -------------------------------------
                                   Name:  Sherrill Neff
                                   Title: Member

                                   GARDEN STATE LIFE SCIENCES
                                   VENTURE FUND, L.P.
                                   By: Quaker Bioventures Capital, L.P.,
                                   Its:    General Partner

                                   By: Quaker Bioventures Capital, LLC.,
                                   Its:    General Partner

                                   By: /s/ Sherrill Neff
                                       -------------------------------------
                                   Name:   Sherrill Neff
                                   Title:  Member

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