Document:

Exhibit 4.72

 

SATISFACTION: The debt evidenced by this

Note has been satisfied in full this ________ day

of ________________________, 20_________

 

 

 

 

 

PURCHASE MONEY PROMISSORY NOTE

 

 

	$3,900,000.00	December 19, 2016

 

FOR VALUE RECEIVED, AMYRIS, INC., a Delaware
corporation (“Borrower”), promises to pay to NIKKO CHEMICALS CO., LTD., a Japanese company (“Lender”),
the principal sum of THREE MILLION NINE HUNDRED THOUSAND and 00/100 DOLLARS ($3,900,000.00), with interest at the fixed rate of
five percent (5.0%) per annum on the unpaid balance until paid or until default, both principal and interest payable in lawful
money of the United States of America, at the office of Lender at 1-4-8, Nihonbashi-Bakurocho, Chuo-ku, Tokyo 103-0002, Japan,
or at such place as the legal holder hereof may designate in writing. The principal and interest shall be due and payable as follows:

 

(A)       $400,000
to be paid in equal monthly installments of $100,000 on January 1, 2017, February 1, 2017, March 1, 2017 and April 1, 2017.

 

(B)       In
addition, level monthly payments of principal and interest on the first day of each month, commencing January 1, 2017, and continuing
on the first day of each successive month thereafter up to and including December 1, 2029, in the amount of $30,557.09 shall be
due and payable on the first day of each month. All outstanding principal and accrued unpaid interest being due and payable on
or before the date thirteen (13) years from the date hereof.

 

Each such installment shall, unless otherwise
provided, be applied first to payment of interest then accrued and due on the unpaid principal balance, with the remainder applied
to the unpaid principal.

 

Unless otherwise provided, this Note may be
prepaid in full or in part at any time without penalty or premium. Partial prepayments shall be applied to installments due in
reverse order of their maturity.

 

Any payment of principal and interest due hereunder
which is not paid within five (5) days after the due date shall incur a late payment fee of five percent (5%) of the amount of
the delinquent payment.

 

In the event of (a) default in payment of any
installment of principal or interest hereof as the same becomes due and such default is not cured within fifteen (15) days from
the due date, or (b) default under the terms of any instrument securing this Note, and such default is not cured within fifteen
(15) days after written notice to maker, then in either such event the holder may without further notice, declare the remainder
of the principal sum, together with all interest accrued thereon and, the prepayment premium, if any, at once due and payable.
Failure to exercise this option shall not constitute a waiver of the right to exercise the same at any other

 

     

     

    

 

time. The unpaid principal of this Note and any part thereof, accrued interest and all other sums due under this Note, if any,
shall bear interest at the rate of eight percent (8%) per annum after default until paid.

 

All parties to this Note, including maker and
any sureties, endorsers, or guarantors hereby waive protest, presentment, notice of dishonor, and notice of acceleration of maturity
and agree to continue to remain bound for the payment of principal, interest and all other sums due under this Note notwithstanding
any change or changes by way of release, surrender, exchange, modification or substitution of any security for this Note or by
way of any extension or extensions of time for the payment of principal and interest; and all such parties waive all and every
kind of notice of such change or changes and agree that the same may be made without notice or consent of any of them.

 

Upon default the holder of this Note may employ
an attorney to enforce the holder’s rights and remedies and the maker, principal, surety, guarantor and endorsers of this
Note hereby agree to pay to the holder reasonable attorneys’ fees, plus all other reasonable expenses incurred by the holder
in exercising any of the holder's rights and remedies upon default.

 

This Note is to be governed and construed in
accordance with the laws of the State of Delaware.

 

This Note is given in connection with the purchase
of real and personal property located in North Carolina.

 

IN TESTIMONY WHEREOF, the undersigned has caused
this instrument to be executed in its company name by its duly authorized manager the day and year first above written.

 

 

	 	AMYRIS, INC.	 
	 	 	 	 
	 	 	 	 
	 	By:	/s/ Raffi Asadorian	 
	 	 	 	 
	 	Name: Raffi Asadorian	 
	 	 	 	 
	 	Title: Chief Financial Officer

 

 

 

 

 

 

 

 

2CONFIDENTIAL
TREATMENT REQUESTED. CERTAIN PORTIONS OF THIS DOCUMENT HAVE BEEN OMITTED PURSUANT TO A REQUEST FOR CONFIDENTIAL TREATMENT AND,
WHERE APPLICABLE, HAVE BEEN MARKED WITH AN ASTERISK TO DENOTE WHERE OMISSIONS HAVE BEEN MADE. THE CONFIDENTIAL MATERIAL HAS BEEN
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION.

 

Exhibit 10.02

 

MODIFICATION P00001 TO THE TECHNOLOGY INVESTMENT AGREEMENT

 

Between

 

AMYRIS, INC.,

5885 Hollis Street Suite 100

Emeryville, CA 94608

 

And

 

The Defense Advanced Research Projects Agency

675 North Randolph Street

Arlington, VA 22203-2114

 

Concerning

 

Improving the Timeline for Scaling Up Molecules from Proof Of Concept to Market
Reducing Time and Cost

(Mgs TO Kgs)

 

Agreement No.: HR0011-15-3-0001

DARPA Order No.: HR0011518718

	Total Amount of the Agreement:	 	$	50,721,349	 
	Total Estimated Government Funding of the Agreement:	 	$	35,160,011	 
	Contractor Share Contribution	 	$	15,551,338	 
	Funds Obligated:	 	$	6,035,686	 
	Funds Obligated by this Modification	 	$	0.00	 

 

 

	Recipient Identification Number/Codes:	DUNS: 185930182
	 	CAGE: 47QN9
	 	TIN: 

 

 

Authority: 10 U.S.C. § 2371

 

All provisions, terms, and conditions set forth in this Agreement are applicable and
in full force and effect except as specified otherwise herein.

 

	FOR AMYRIS, INC	 	FOR THE DEFENSE ADVANCED RESEARCH
PROJECTS AGENCY
	 	 	 
	 	 	 
	 	 	 
	/s/ Joel R. Cherry	 	/s/ Michael S. Mutty
	Joel R. Cherry, President, R&D	 	
        Michael S. Mutty

        Agreements Officer

        Contracts Management Office

         

	 	 	 
	10/15/2015	 	10/22/2015
	(Date)	 	(Date)
	 	 	 

 

     

     

    

Agreement HR0011-15-3-0001

MODIFICATION P00001

 

In order to incorporate changes in Agreement Table of Contents, and Article I, subparagraph
A. Background and to move task B5 from Technical Milestone to Technical Milestone 6 in Attachments (3) Total Agreement Funding
Plan and Payable Milestones and Corresponding Payment Schedule, the following changes are made:

 

1.       The Technology Investment Agreement, Table
of Contents – Attachments is revised to read as follows:”

 

ATTACHMENTS

 

	ATTACHMENT 1	 	Statement of Work
	ATTACHMENT 2	 	Report Requirements
	ATTACHMENT 3 – Revision 1	 	Total Agreement Funding Plan and Payable Milestones and Corresponding Payment Schedule
	ATTACHMENT 4	 	Funding Schedule
	ATTACHMENT 5	 	List of Intellectual Property Assertions by the Performer
	ATTACHMENT 6	 	List of Property Greater than $5,000
	ATTACHMENT 7	 	Certifications for Agreement No. HR0011-15-3-0001

 

2. The Technology Investment Agreement, Article I, Scope of the Agreement, subparagraph
A. Background is revised to read as follows:

 

ARTICLE I: SCOPE OF THE AGREEMENT

 

A.       Background

 

Performer is a leader in applying synthetic biology technologies
to engineer living organisms into manufacturing platforms that are able to produce a wide variety of target molecules, many of
which are impossible to produce through traditional manufacturing processes. While current technologies are highly advanced, they
suffer from a lack of integration and automation. By focusing on the same principles that made the United States the leaders in
traditional manufacturing, namely standardized engineering and efficiency gains through automation, the Performer seeks, through
funding in this Agreement, to develop a state of the art open bio-fabrication facility that will shorten the scale-up time and
cost by using biology to produce molecules. Many of these molecules are directly relevant to the DoD mission due to their unique
chemical properties that enable their use as fuels, lubricants, anti-fouling agents, antibiotics, and adhesives while also providing
building blocks for novel families of materials. DARPA’s interest in synthetic biology rises from its potential application
to manufacturing. Biological manufacturing is in its infancy and the work required to reduce the time, effort, and cost needed
to develop a new microbe is risky and at odds with the work needed to bring a product to market which is the chief goal of any
company seeking to capitalize on the technology. The Agreement supports research with a long-term perspective that will enable
academic and commercial participants to perform cutting edge research with less effort and cost than ever before. In addition to
producing molecules relevant to the DoD, the commercial opportunities are immense since virtually any molecule made through traditional
manufacturing processes can be replicated using biology as a catalyst. Although engineering cellular factories has been intermittently
successful, the cost and time required for success have been prohibitive. The Performer’s new technological approach will
develop new molecules and materials while at the same time improving efficacy and efficiency. As a result of these improvement,
the United States will reduce production time to under three years and at less than $10M per molecule while simultaneously handling
100 molecules, a 20X improvement. To achieve these innovations, the Performer will focus on technology development addressing metabolic
pathway and enzyme design, strain construction, phenotypic measurements, large-scale data analysis, and strain optimization. To
ensure success, the Performer will complement its expertise in strain engineering by partnering with companies and academic laboratories
that are leaders in their field. Upon the completion of this agreement, the capacity to perform biological engineering will far
surpass current capabilities. The United States will possess state of the art facilities for design and biomanufacturing of existing
and novel molecules and materials.

 

     

     

    

Agreement HR0011-15-3-0001

MODIFICATION P00001

 

3. Attachment (3) Total Agreement Funding Plan and Payable Milestones and Corresponding
Payment Schedule is deleted and replaced with Attachment (3) Total Agreement Funding Plan and Payable Milestones and Corresponding
Payment Schedule – Revision 1 which moves task B5 from Technical Milestone 7 to Technical Milestone 6. As a result of this
move Technical Milestone 6 payment value is [*] and Technical Milestone 7 payment value is [*].

 

 

 

 

 

 

 

 

[*] Certain portions denoted with an asterisk have been omitted
and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the
omitted portions.

 

     

     

    

 

TECHNOLOGY INVESTMENT AGREEMENT

 

BETWEEN

 

AMYRIS, INC.,

5885 HOLLIS STREET SUITE 100

EMERYVILLE, CALIFORNIA 94608

 

AND

 

THE DEFENSE ADVANCED RESEARCH PROJECTS AGENCY

675 NORTH RANDOLPH STREET 

ARLINGTON, VA 22203-2114

 

CONCERNING

 

IMPROVING THE TIMELINE FOR SCALING UP MOLECULES
FROM PROOF OF CONCEPT 

TO MARKET REDUCING TIME AND COST

(MGS TO KGS)

 

Agreement No.: HR0011-15-3-0001

DARPA Order No.: HR0011518718

Total Amount of the Agreement: $50,721,349

Total Estimated Government Funding of the Agreement: $35,160,011

Funds Obligated: $6,035,686

Authority: 10 U.S.C. § 2371

 

 

 

Line of Appropriation – See Article V.C.

 

 

 

This Agreement is entered into between the United
States of America, hereinafter called the Government, represented by The Defense Advanced Research Projects Agency (DARPA), and
AMYRIS, INC., a corporation organized and existing under the laws of the State of Delaware with its principal place of business
at 5885 Hollis Street, Suite 100, Emeryville, California 94608 pursuant to and under U.S. Federal law.

 

	FOR AMYRIS, INC	 	FOR THE DEFENSE ADVANCED RESEARCH
PROJECTS AGENCY
	 	 	 
	 	 	 
	 	 	 
	(Signature & Date)	 	(Signature & Date)
	 	 	 
	
         

         

         
	 	
        Michael S. Mutty

        Agreements Officer

         

	(Name, Title)	 	(Name, Title)
	 	 	 

 

 

     

    Agreement HR0011-15-3-0001

    

 

TABLE OF CONTENTS

 

 

	ARTICLES	 	PAGE
	 	 	 
	ARTICLE I	Scope of the Agreement	3
	ARTICLE II	Term	7
	ARTICLE III	Management of the Project	10
	ARTICLE IV	Agreement Administration	11
	ARTICLE V	Obligation and Payment	12
	ARTICLE VI	Disputes	15
	ARTICLE VII	Patent Rights	16
	ARTICLE VIII	Data Rights	19
	ARTICLE IX	Foreign Access to Technology	21
	ARTICLE X	Title to and Disposition of Property	22
	ARTICLE XI	Civil Rights Act	23
	ARTICLE XII	Security	23
	ARTICLE XIII	Subcontractors	23
	ARTICLE XIV	Key Personnel	23
	ARTICLE XV	Order of Precedence	23
	ARTICLE XVI	Execution	23
	ARTICLE XVII	Applicable Law	24
	ARTICLE XVIII	Severability	24
	ARTICLE XIX	Data Sharing Plan and Status Reporting	24

 

ATTACHMENTS

 

	ATTACHMENT 1	 	Statement of Work
	ATTACHMENT 2	 	Report Requirements
	ATTACHMENT 3 – Revision 1	 	Total Agreement Funding Plan and Payable Milestones and Corresponding Payment Schedule
	ATTACHMENT 4	 	Funding Schedule
	ATTACHMENT 5	 	List of Intellectual Property Assertions by the Performer
	ATTACHMENT 6	 	List of Property Greater than $5,000
	ATTACHMENT 7	 	Certifications for Agreement No. HR0011-15-3-0001

 

    	2 of 25

    Agreement HR0011-15-3-0001

    

 

ARTICLE I: SCOPE OF THE AGREEMENT

 

A.       Background

 

Performer is a leader in applying synthetic biology technologies
to engineer living organisms into manufacturing platforms that are able to produce a wide variety of target molecules, many of
which are impossible to produce through traditional manufacturing processes. While current technologies are highly advanced, they
suffer from a lack of integration and automation. By focusing on the same principles that made the United States the leaders in
traditional manufacturing, namely standardized engineering and efficiency gains through automation, the Performer seeks, through
funding in this Agreement, to develop a state of the art open bio-fabrication facility that will shorten the scale-up time and
cost by using biology to produce molecules. Many of these molecules are directly relevant to the DoD mission due to their unique
chemical properties that enable their use as fuels, lubricants, anti-fouling agents, antibiotics, and adhesives while also providing
building blocks for novel families of materials. DARPA’s interest in synthetic biology rises from its potential application
to manufacturing. Biological manufacturing is in its infancy and the work required to reduce the time, effort, and cost needed
to develop a new microbe is risky and at odds with the work needed to bring a product to market which is the chief goal of any
company seeking to capitalize on the technology. The Agreement supports research with a long-term perspective that will enable
academic and commercial participants to perform cutting edge research with less effort and cost than ever before. In addition to
producing molecules relevant to the DoD, the commercial opportunities are immense since virtually any molecule made through traditional
manufacturing processes can be replicated using biology as a catalyst. Although engineering cellular factories has been intermittently
successful, the cost and time required for success have been prohibitive. The Performer’s new technological approach will
develop new molecules and materials while at the same time improving efficacy and efficiency. As a result of these improvement,
the United States will reduce production time to under three years and at less than $10M per molecule while simultaneously handling
100 molecules, a 20X improvement. To achieve these innovations, the Performer will focus on technology development addressing metabolic
pathway and enzyme design, strain construction, phenotypic measurements, large-scale data analysis, and strain optimization. To
ensure success, the Performer will complement its expertise in strain engineering by partnering with companies and academic laboratories
that are leaders in their field. Upon the completion of this agreement, the capacity to perform biological engineering will far
surpass current capabilities. The United States will possess state of the art facilities for design and biomanufacturing of existing
and novel molecules and materials.

 

 

    	3 of 25

    Agreement HR0011-15-3-0001

    

 

B.       Definitions

 

Affiliate: means, with respect to an entity, any person or
entity that directly or indirectly, through one or more intermediaries, controls, is controlled by, or is under common
control with such first entity. For purposes of this definition, “control”, “controlled by”, and
“under common control with” mean (i) the possession, directly or indirectly, of the power to direct the
management or policies of an entity, whether through the ownership of voting securities, by contract relating to voting
rights or corporate governance, or otherwise or (ii) the ownership, directly or indirectly, of more than fifty percent (50%)
of the voting securities or other ownership interest of an entity.

 

Agreement:  The body of this Agreement and Attachments 1 – 7,
which are expressly incorporated in and made a part of the Agreement.

 

Collaborators:  A third party in a contractual arrangement with the
Performer or with a Subcontractor, whether executed before or after the Effective Date, under which arrangement the Performer or
a Subcontractor has agreed to jointly research, develop and/or commercialize a technology or product with such third party and
has an “active role” in such arrangement. For the avoidance of doubt, an “active role” by the Performer
or a Subcontractor is a contractual relationship (1) that involves more than the mere transfer of intellectual property and (2)
where the Performer or a Subcontractor has a significant participation in decision making and/or funding of the activities.

 

Data:  Recorded information, regardless of form or method of recording, which
includes but is not limited to, scientific or technical data, software, trade secrets, and mask works, in each case developed or
generated by the Performer or its Subcontractors in performing the Program under this Agreement. The term “Data” does
not include financial, administrative, cost, pricing or management information.

 

Effective Date: means November 1, 2015.

 

Foreign Firm or Institution:  A firm or institution organized or existing
under the laws of a country other than the United States, its territories, or possessions. The term includes, for purposes of this
Agreement, any agency or instrumentality of a foreign government; and firms, institutions or business organizations which are owned
or substantially controlled by foreign governments, firms, institutions, or individuals.

 

Government:  The United States of America, as represented by DARPA.

 

Government Purpose Rights:  The rights to use, duplicate, or disclose
Data, in whole or in part and in any manner, for Government Purposes only, and to have or permit others to do so for Government
Purposes only.

 

Government Purpose:  Any activity in which the Government is a party,
including cooperative agreements with international or multi-national defense organizations or sales or transfers by the Government
to foreign governments or international organizations. Government Purposes include competitive procurement, but do not include
the rights to use, modify, reproduce, release, perform, display, or disclose Data for commercial purposes or authorize others to
do so.

 

Invention:  Any invention or discovery which is or may be patentable or otherwise
protectable under Title 35 of the United States Code.

 

Know-How:  All information including, but not limited to discoveries,
formulas, materials, Inventions, processes, ideas, approaches, concepts, techniques, methods, software, programs, documentation,
procedures, firmware, hardware, technical data, specifications, devices, apparatus and machines.

 

    	4 of 25

    Agreement HR0011-15-3-0001

    

 

Limited Rights:  The rights to use, modify, reproduce, release, perform,
display, or disclose Data, in whole or in part, within the Government. The Government may not, without the written permission of
the Party asserting limited rights, release or disclose applicable Data outside the Government, use the applicable Data for manufacture,
or authorize the applicable Data to be used by another party, except that the Government may
reproduce, release, or disclose such Data or authorize the use or reproduction of the applicable Data by persons outside the Government
if -

 

		(i)	The reproduction, release, disclosure , or use is:

		A.	Necessary for emergency repair and overhaul; or

		B.	A release or disclosure to

1. A covered Government support contractor in performance
of its covered Government support contract for use, modification, reproduction, performance, display or release or disclosure to
a person authorized to receive Limited Rights Data; or

2. A foreign government, of such Data other than detailed
manufacturing or process Data, when use of such Data by the foreign government is in the interest of the Government and is required
for evaluational or informational purposes;

		(ii)	The recipient of the applicable Data is subject to a prohibition on the further reproduction, release, disclosure, or use of
the Data; and

		(iii)	The Performer, or its subcontractor asserting the restriction is notified of such reproduction, release, disclosure, or use.

 

Made:  Relates to any Invention means the conception or first actual
reduction to practice of such Invention.

 

Parties: The Government (represented by DARPA) and the Performer.

 

Payable Milestone: A Program-related task or tasks identified in Attachment 3
for which a corresponding payment (also identified in Attachment 3) will be made by the Government to the Performer upon the Government’s
verification, in accordance with this Agreement, that the Performer (or a Subcontractor) accomplished such task(s).

 

Performer:  AMYRIS, INC. a corporation organized and existing under the laws of
the State of

Delaware with its principal place of business at 5885 Hollis Street, Suite 100, Emeryville,
California

94608

 

Practical Application:  To manufacture, in the case of a composition
of product, to practice, in the case of a process or method, or to operate, in the case of a machine or system; and, in each case,
under such conditions as to establish that the Subject Invention is capable of being utilized and that its benefits are, to the
extent permitted by law or Government regulations, available to the public on reasonable terms. For the avoidance of doubt, the
Parties acknowledge that “Practical Application” under this Agreement may not include actual commercialization of Subject
Invention(s) hereunder because such Subject Invention(s) are likely to be Tools (e.g., it is envisioned that the Tools resulting
from the research carried out under this Agreement will later – outside of this Agreement - be used by the Performer and
its Subcontractors to develop commercial products).

 

Program: Research and development being conducted by the Performer
and its Subcontractors under this Agreement, as set forth in Article I, paragraph C and in Attachment 1, Statement of Work.

 

Property:  Any tangible personal property other than property actually
consumed during the execution of work under this Agreement.

 

    	5 of 25

    Agreement HR0011-15-3-0001

    

 

Subcontractor: Those persons or entities that, per a written agreement
with the Performer, will perform certain of the Payable Milestones. As of the date of this Agreement, the Subcontractors consist
of Agilent Technologies, Inc., Arzeda Corporation, m2p-labs GmbH, Ruprecht-Karls-Universität Heidelberg, and Bruker Corporation.

 

Subject Invention:  Any Invention conceived or first actually reduced
to practice in the performance of the Program under this Agreement that is capable of use as a Tool for making or altering a genetically
modified organism; provided however, any Inventions, regardless when conceived or reduced to practice, covering a genetically modified
organism, a strain, or any compound or product made by or from an organism or strain shall not be considered “Subject Inventions”
hereunder. For the avoidance of doubt, no Inventions conceived or reduced to practice prior to the Effective Date, excluding subject
inventions conceived or first actually reduced to practice under the Amyris Living Foundries TIA HR0011-12-3-0006, shall be considered
performed “under this Agreement.”

 

Technology:  Discoveries, innovations, Know-How and Inventions, whether
patentable or not, including computer software, recognized under U.S. law as intellectual creations to which rights of ownership
accrue, including, but not limited to, patents, trade secrets, maskworks, and copyrights, developed under this Agreement.

 

Term: has the meaning set forth in Article II, paragraph A.

 

Tools: Software, analytical methods, standard operating procedures,
and workflow processes.

 

Unlimited Rights:  Rights to use, duplicate, release, or disclose Data,
in whole or in part, in any manner and for any purposes whatsoever, and to have or permit others to do so.

 

C.       Scope

 

1.       The Performer
shall perform the Program, which is intended to build an open BioFab that shortens the timeline for scaling up molecules from proof
of concept to market to two to three years, reduces the cost of such development to less than $10 million per molecule, and simultaneously
handles a hundred molecules. Success will be demonstrated by delivering 1 kg of material for 10 molecules generated by an integrated
pipeline that enables the biological production of metric tons of any subsequent molecule in two to three years. The Program shall
be carried out in accordance with the Statement of Work incorporated in this Agreement as Attachment 1. The Performer shall submit
or otherwise provide all documentation required by Attachment 2, Report Requirements.

 

2.       The Performer
shall be paid for each Payable Milestone accomplished in accordance with the Schedule of Payments and Payable Milestones set forth
in Attachment 3 and the procedures of Article V. The Schedule of Payments and Payable Milestones set forth in Attachment 3 may
be revised or updated in accordance with Article III, subject to mutual agreement of the Parties.

 

3.       The Government and the
Performer estimate that the Statement of Work for this Agreement can only be accomplished with the Performer’s provision
during the Term of the “Performer Contribution”, as detailed in the Total Agreement Funding Plan set forth in Attachment
3 and the Funding Schedule set forth in Attachment 4. The Total Agreement Funding Plan and the Funding Schedule may be revised
or updated in accordance with Article III, subject to mutual agreement of the Parties. The Performer intends and, by entering into
this Agreement, undertakes to cause the Performer Contribution to be provided. However, if either the Government or the Performer
is unable to provide its respective funding (in the case of the Government) or the Performer Contribution (in the case of the Performer)
for the Program, the other Party may reduce its funding or Performer Contribution, whichever is applicable to it, for
the Program by a proportional amount. Throughout the Term, the Parties, through the Performer’s routine reports to the Government,
will monitor the Performer’s satisfaction of the Performer Contribution and will promptly address, in good faith, any divergence
or shortfall in the final Performer Contribution amount anticipated by the Performer (e.g., the Performer purchases Property for
the Program at a price significantly cheaper than what was anticipated when establishing the Performer Contribution) and its effect,
if any, on the Government’s funding obligation under this Agreement.

 

    	6 of 25

    Agreement HR0011-15-3-0001

    

 

D.       Goals / Objectives

 

1.       The goal of
this Agreement is for the Performer to investigate and build a BioFab that scales up molecules from proof of concept to market
in less time and at less cost, as described under Scope above. The goal is to accomplish this by incorporating radical innovations
into key modules at each stage of the Design-Build-Test-Learn cycle as described in detail Amyris Proposal “Mgs to Kgs”
dated February 3, 2015. The modules will be interdependent and align within an integrated pipeline. The foundation is a set of
measurement technologies with various levels of risk. In addition to new algorithms for pathway prediction, data analysis and hypothesis
generation, the BioFab’s testing and optimization of up to 450 molecules from a large metabolic space will require a paradigm
shift from a high-throughput, single-molecule screening platform to a high throughput, molecule-agnostic screening platform that
is predictive of performance to a large scale. To address the gaps in throughput, quality and scale, a testing platform that utilizes
a tiered approach to promote strains will be developed. Although individual tiers exist in some form at various institutions and
companies (including at the Performer), there is not a single platform that has managed to encompass all of them into a single
pipeline at the proposed scale.

 

2.       The Government
will have continuous involvement with the Performer. The Government will also obtain access to research results and certain rights
in Data and Subject Inventions pursuant to Articles VII and VIII. Government and the Performer are bound to each other by a duty
of good faith and best research effort in achieving the goals of the Program.

 

3.       This Agreement
is an "other transaction" pursuant to 10 U.S.C. § 2371. The Parties agree that the principal purpose of this Agreement
is for the Government to support and stimulate the Performer to provide its best effort in advanced research and technology development
and not for the acquisition of property or services for the direct benefit or use of the Government. The Performer will be paid
a fixed amount for each Payable Milestone accomplished in accordance with the Payable Milestones and Corresponding Payment Schedule
set forth in Attachment 3 and the procedures of Article V. The Parties agree that the amount payable to Performer for an accomplished
Payable Milestone will be unaffected by whether Performer ends up expending more or less effort to accomplish such Payable Milestone
than the Parties assumed would be required to accomplish it. This Agreement is not intended to be, nor shall it be construed as,
by implication or otherwise, a partnership, a corporation, or other business organization.

 

ARTICLE II: TERM

 

A.       Term of this Agreement

 

The Program commences upon the Effective Date and continues
for forty-eight (48) months, unless extended as described in paragraph C below, (the “Term”) and is split into three
development and operational phases described below and depicted in the table:

 

“Dev” – in the first twenty-four months, the initial set of
strain designs and testing will be generated using existing infrastructure and processes, while simultaneously developing the new
technology platforms simultaneously;

 

    	7 of 25

    Agreement HR0011-15-3-0001

    

 

“DevOps” – newly developed technology platforms will be transferred
to pipeline operations as part of the beta-testing transition process;

 

“Ops” – once the technology transfer is completed, the new
technologies will be part of standard operations.

 

If all Government funds committed for the Program and the
Performer Contribution are expended prior to the expiration of the Term, the Parties have no obligation to continue performance
of the Program and may elect to cease development at that point.

 

Provisions of this Agreement, which, by their express terms
or by necessary implication, apply for periods of time other than specified herein, shall be given effect, notwithstanding this
Article.

 

 

 

 

 

 

    	8 of 25

    Agreement HR0011-15-3-0001

    

 

 

 

 

 

 

[*]

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

[*] Certain portions denoted with an asterisk have been omitted
and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the
omitted portions.

 

     

    Agreement HR0011-15-3-0001

    

 

B.       Termination Provisions

 

Subject to a reasonable determination that the Program will
not produce beneficial results commensurate with the expenditure of resources, either Party may terminate this Agreement by written
notice to the other Party, provided that such written notice is preceded by consultation between the Parties. In the event
of a termination of the Agreement under this paragraph B, it is agreed that disposition of Data shall be in accordance with the
provisions set forth in Article VIII, Data Rights. The Government and the Performer will negotiate in good faith a reasonable and
timely adjustment of all outstanding issues between the Parties as a result of termination under this paragraph B. Failure of the
Parties to agree to a reasonable adjustment will be resolved pursuant to Article VI, Disputes. The Government has no obligation
to pay the Performer beyond the last completed and paid Payable Milestone if the Performer decides to terminate under this paragraph
B. For the avoidance of doubt, any termination under this paragraph B by either Party does not require repayment by the Performer
of any Payable Milestone amounts already received by the Performer.

 

C.       Extending the Term

 

The Parties may extend, by mutual written agreement, the
Term if funding availability and research opportunities reasonably warrant. Any extension shall be formalized through modification
of the Agreement by the DARPA Agreements Officer and the Performer’s Administrator.

 

ARTICLE III: MANAGEMENT OF THE PROJECT 

 

A.       Management and Program Structure

 

The Performer shall be responsible for the overall technical
and program management of the Program, and technical planning and execution shall remain with the Performer. The DARPA Agreements
Officer’s Representative, in consultation with the DARPA Program Manager or DARPA management, shall provide recommendations
to Program developments and technical collaboration and be responsible for the review and verification of the Payable Milestones.

 

B.       Program Management Planning Process

 

Program planning will consist of an Annual Program Plan with inputs
and review from the Performer and DARPA management, containing the detailed schedule of research activities and Payable Milestones.
The Annual Program Plan will consolidate quarterly adjustments in the Program’s research schedule, including revisions/modification
to Payable Milestones.

 

1.       Initial
Program Plan: The Performer will follow the initial program plan that is contained in the Statement of Work, Attachment 1, and
in the Payable Milestones and Corresponding Payment Schedule, Attachment 3.

 

2.       Overall Program Plan Annual
Review

 

(a)       The
Performer, with DARPA Agreements Officer’s Representative review, in consultation with the DARPA Program Manager or
DARPA management, will prepare an overall Annual Program Plan in the last month of each Agreement year (i.e.,
October). The Annual Program Plan will be presented and reviewed at an annual site review, to be held within the sixty (60)
days of each subsequent Agreement year, which will be attended by the Performer’s Key Personnel (as defined in Article
XIV), the DARPA Agreements Officer’s Representative, senior DARPA management (as appropriate), and other DARPA program
managers and personnel (as appropriate). The Performer, with DARPA participation and review, will prepare a final Annual
Program Plan following such annual site review as more fully described in Attachment 2, Report Requirements.

 

    	10 of 25

    Agreement HR0011-15-3-0001

    

 

(b)       The Annual
Program Plan provides a detailed schedule of the Program’s research activities, commits the Performer to use its best efforts
to meet specific performance objectives, includes forecasted expenditures and describes the Payable Milestones. The Annual Program
Plan will consolidate all prior adjustments in the Program’s research schedule, including revisions/modifications to the
Payable Milestones. Recommendations for changes, revisions or modifications to the Agreement which result from this annual review
process shall be made in accordance with the provisions of Article III, paragraph C.

 

C.        Modifications

 

1.       As a result of
the Parties’ meetings (in person or videoconference) or annual reviews or at any other time during the Term, the Program’s
research progress or results or other changes in circumstances (e.g., availability of required materials or equipment from external
vendors, legal freedom to operate, etc.) may indicate that a change in the Statement of Work and/or the Payable Milestones would
be beneficial to Program’s objectives. Recommendations for modifications, including justifications to support any changes
to the Statement of Work and/or the Payable Milestones, will be documented in a letter and submitted by the Performer to the DARPA
Agreements Officer’s Representative with a copy to the DARPA Agreements Officer. This documentation letter will detail the
technical, chronological, and financial impact of the proposed modification to the Program. The Performer shall approve any Agreement
modification. The Government is not obligated to pay for additional or revised Payable Milestones until the Payable Milestones
and Corresponding Payment Schedule, Attachment 3, is formally revised by the DARPA Agreements Officer and made part of this Agreement.

 

2.       The DARPA Agreements
Officer’s Representative shall be responsible for the review and verification of any recommendations to revise or otherwise
modify the Agreement, the Statement of Work, the Payable Milestones and Corresponding Payment Schedule, or any other proposed changes
to the terms and conditions of this Agreement.

 

3.       For
minor or administrative Agreement modifications (e.g., changes in the paying office or appropriation data, changes to Government
or the Performer’s personnel identified in the Agreement, etc.), no signature is required by the Performer.

 

ARTICLE IV: AGREEMENT ADMINISTRATION

 

Unless otherwise provided in this Agreement, approvals permitted
or required to be made by the Government may be made only by the DARPA Agreements Officer. Administrative and contractual matters
under this Agreement shall be referred to the following representatives of the Parties:

 

A.          
Government Points of Contact:

 

DARPA Agreements Officer:

 

 

DARPA Program Manager:

 

 

DARPA Agreements Officer’s Representative (AOR):

 

 

    	11 of 25

    Agreement HR0011-15-3-0001

    

 

DARPA Administrative Agreements Officer (AAO):

 

 

DARPA Assistant Director, Program Management (ADPM)

 

 

B.       Performer Points of Contact

 

Administrator:

  , Program Manager, R&D, 

 

Contracting:

   , General Counsel, 

 

Program Manager:

  , PI,        

 

BioAnalytics Group Leader:

  , Co-PI,       

 

Each Party may change its representatives named in this Article by written notification
to the other Party. The Government will effect the change as stated in Article III, C.3 above.

 

ARTICLE V: OBLIGATION AND PAYMENT

 

A.       Obligation

 

1.       The Government’s
liability to make payments to the Performer is limited to only those funds obligated under the Agreement or by modification to
the Agreement. The Government may obligate funds to the Agreement incrementally.

 

2.       If modification
of a Payable Milestone becomes necessary in performance of this Agreement, pursuant to Article III, paragraph C, the DARPA Agreements
Officer and the Performer’s Administrator shall execute a revised Payable Milestones and Corresponding Payment Schedule consistent
with the then current Annual Program Plan.

 

B.       Payments for Accomplished Payable Milestones

 

1.       The Performer
has, and agrees to maintain, an established accounting system, which complies with Generally Accepted Accounting Principles and
the requirements of this Agreement and shall ensure that appropriate arrangements have been made for receiving, distributing and
accounting for all funding. An acceptable established accounting system is one in which all cash receipts and disbursements are
controlled and documented properly.

 

2.       Once the
Performer accomplishes a Payable Milestone, the Performer may seek payment from the Government of the corresponding payment amount
in the Payable Milestones and Corresponding Payment Schedule in Attachment 3. The Performer shall document the accomplishment
of such Payable Milestone by submitting or otherwise providing the Payable Milestones Report required by Attachment 2, Part F.
After written verification of the accomplishment of such Payable Milestone by the DARPA Agreements Officer’s Representative
and approval by the DARPA Agreements Officer, the associated invoice will be submitted to the payment office via Wide Area Workflow
(“WAWF”), as detailed in subparagraph B.6 of this Article. If a Payable Milestone is composed of more than one task
(e.g., Payable Milestones 2, 6, 7, etc.), all such tasks in such Payable Milestone must be fully accomplished before
the Performer may seek payment for such Payable Milestone. However, if a task in a single task Payable Milestone (or all of the
tasks in a multi-task Payable Milestone) cannot be completed by the applicable Milestone (MS) Month set forth in Attachment 3,
the Performer will document such event in its Monthly Technical Status Report, and the Parties will execute a contract modification
to incorporate required changes in Attachment 3, and in Attachments 1 and 4, as applicable. For clarity, the “MS Month”
column set forth in Attachment 3 sets forth the Parties’ good faith estimate of the date by which a Payable Milestone will
be accomplished, but it is not a deadline for accomplishing the applicable Payable Milestone. In addition, missing the MS Month
does not prevent the Performer from subsequently accomplishing the applicable Payable Milestone and has no effect on the corresponding
payment amount in Attachment 3 once accomplished.

 

    	12 of 25

    Agreement HR0011-15-3-0001

    

 

If deemed necessary by the DARPA Agreements Officer, payment
approval for the final Payable Milestone will be made after reconciliation of actual Government funding for the Program with the
actual Performer Contribution amount. While there will be this final Government reconciliation and accounting of the Performer
Contribution amount, the Parties agree that the quarterly accounting of the Performer Contribution, as reported in the quarterly
Business Status Report submitted in accordance with Attachment 2, will not, nor is it necessarily intended or required to, uniformly
or proportionally track or match the estimated schedule of the Performer Contribution set forth in either Attachments 3 or 4.

 

3.       Subject to
change only through written Agreement modification, payment shall be made to the address of the Performer’s Administrator
set forth below.

 

AMYRIS, INC., 5885 Hollis Street, Suite 100, Emeryville, California
94608

 

4.       Payments will
be made by the cognizant Defense Agencies Financial Services office, as indicated below, within thirty (30) calendar days of an
accepted invoice in WAWF. WAWF is a secure web-based system for electronic invoicing, receipt and acceptance. The WAWF application
enables electronic form submission of invoices, government inspection, and acceptance documents in order to support DoD’s
goal of moving to a paperless acquisition process. Authorized DoD users are notified of pending actions by e-mail and are presented
with a collection of documents required to process the contracting or financial action. It uses Public Key Infrastructure (“PKI”)
to electronically bind the digital signature to provide non-reputable proof that the user (electronically) signed the document
with the contents. Benefits include online access and full spectrum view of document status, minimized re-keying and improving
data accuracy, eliminating unmatched disbursements and making all documentation required for payment easily accessible.

 

The Performer is required to utilize the WAWF system when
processing invoices and receiving reports under this Agreement. The Performer shall (i) ensure an Electronic Business Point of
Contact is designated in Central Contractor Registration at http://www.ccr.gov and (ii) register to use WAWF–RA at the https://wawf.eb.mil
site, within ten (10) calendar days after award of this Agreement. Step by step procedures to register are available at the https://wawf.eb.mil
site. The Performer is directed to use the “2-in-1” format when processing invoices.

 

a.       For the Issue By DoDAAC
enter HR0011

b.       For the Admin DoDAAC and Ship To fields, enter S0507A.

c.       For the Service
Acceptor field, enter HR0011, Extension 01.

d.       Leave the
Inspect by DoDAAC, Ship From Code DoDAAC and LPO DoDAAC fields blank unless otherwise directed by the DARPA Agreements Officer
or DARPA Administrative Agreements Officer.

 

    	13 of 25

    Agreement HR0011-15-3-0001

    

 

e.       The following guidance
is provided for invoicing processed under this Agreement through WAWF:

 

• The DARPA Agreements Officer’s Representative identified
at Article IV "Agreement Administration" shall continue to formally inspect and accept the deliverable Payable Milestone
reports. To the maximum extent practicable, the DARPA Agreements Officer’s Representative shall review the Payable Milestone
report(s) and either: 1) provide a written notice of rejection to the Performer which includes feedback regarding deficiencies
requiring correction or 2) written notice of acceptance to the DARPA Administrative Agreements Officer, DARPA Program Manager and
DARPA Agreements Officer.

 

• Acceptance within the WAWF system shall be performed by the
DARPA Agreements Officer upon receipt of a confirmation email, or other form of transmittal, from the DARPA Agreements Officer’s
Representative.

 

• The Performer shall send an email notice to the DARPA Agreements
Officer’s Representative and DARPA Agreements Officer upon submission of an invoice in WAWF (this can be done from within
WAWF).

 

• Payments shall be made by DFAS-CO/WEST (HQ0339)

 

• The Performer agrees, when entering invoices entered in WAWF
to utilize the CLINs associated with each Payable Milestone as delineated at Attachment 3. The description of the CLIN shall include
reference to the associated milestone number along with other necessary descriptive information. The Performer agrees that the
Government may reject invoices not submitted in accordance with this provision.

 

Note for DFAS: The Agreement shall be entered into the DFAS system by CLIN
– Milestone association as delineated at Attachment 3. The Agreement is to be paid out by CLIN – Milestone association.
Payments shall be made using the CLIN (MS)/ACRN association as delineated at Attachment 3.

 

5.       Payee Information:
As identified at Central Contractor Registration.

 

	•		Cage Code: 47QN9

	•		DUNS: 185930182

	•		TIN:

 

6.       Financial Records
and Reports: The Performer shall maintain adequate records to account for accomplishment of all Payable Milestones for which payment
is received by the Performer under this Agreement and shall maintain adequate records to account for the Performer Contribution
provided under this Agreement. Upon completion or termination of this Agreement, whichever occurs earlier, the Performer’s
Administrator shall furnish to the DARPA Agreements Officer a copy of the Final Report required by Attachment 2, Part E. The Performer’s
relevant financial records are subject to examination or audit on behalf of DARPA by the Government for a period not to exceed
three (3) years after expiration or earlier termination of the Term. The DARPA Agreements Officer or designee shall have direct
access to sufficient records and information of the Performer to ensure accomplishment of the Payable Milestones for which payment
was received by the Performer under this Agreement and satisfaction of the Performer Contribution under this Agreement. Such audit,
examination, or access shall be performed during business hours on business days upon reasonable, prior written notice and shall
be subject to the security requirements of the audited party. For clarity, where the labor component of the Performer Contribution
is based upon a fixed price hourly commercial rate(s) documented in a contract (e.g., GSA Schedule contract), the examination
or audit of the labor component of such costs shall be limited to a review of hours worked and shall not include a review of the
rates.

 

    	14 of 25

    Agreement HR0011-15-3-0001

    

 

C.       Accounting and Appropriation Data

 

CLIN/SLIN/ACRN: 0001/01/AA

LOA: 012199 097 0400 000 N 20152016 D 1320 BLTM66 2015.MBT-02.CORE.A DARPA 255

FUNDING AMOUNT: $6,035,686

 

ARTICLE VI: DISPUTES

 

A.       General

 

The Parties shall communicate with one another in good faith and in a timely
and cooperative manner when raising issues under this Article.

 

B.       Dispute Resolution Procedures

 

1.       Any dispute, disagreement,
or misunderstanding between the Government and the Performer concerning questions of fact or law arising from or in connection
with this Agreement, and, whether or not involving an alleged breach of this Agreement, may be raised only under this Article.

 

2.       Whenever disputes,
disagreements, or misunderstandings arise, the Party aggrieved by such dispute, disagreement, or misunderstanding shall provide
written notice to the other Party involved identifying the matter in dispute and inviting the other Party involved in the dispute
to attempt to resolve the issue(s) involved by discussion and mutual agreement as soon as practicable. If the aggrieved Party does
not provide the notification made under subparagraph B.3 of this Article within three (3) months of becoming aware of the dispute,
disagreement, or misunderstanding, then such dispute, disagreement, or misunderstanding will not constitute the basis for relief
under this Article unless the Director of DARPA in the interests of justice waives this requirement.

 

3.       Failing resolution
by mutual agreement described above, the aggrieved Party shall document the dispute, disagreement, or misunderstanding by notifying
the other Party (through the DARPA Agreements Officer or the Performer’s Administrator, as the case may be) in writing of
the relevant facts, identify unresolved issues, and specify the clarification or remedy sought. Within five (5) business days after
providing such notice to the other Party, the aggrieved Party may, in writing, request a joint decision by the DARPA Senior Procurement
Executive and a senior executive (no lower than Vice President, Legal) appointed by the Performer. The other Party shall submit
a written position on the matter(s) in dispute within thirty (30) calendar days after being notified in writing that a joint decision
has been requested regarding the dispute, disagreement, or misunderstanding. The DARPA Senior Procurement Executive and the Performer’s
senior executive shall conduct a review of the matter(s) in dispute and render a decision in writing within thirty (30) calendar
days of receipt of such other Party’s written position. Any such joint decision is final and binding.

 

4.       In the
absence of a joint decision, upon written request to the Director of DARPA, made within thirty (30) calendar days of the
expiration of the time for a joint decision under subparagraph B.3 above, the dispute, disagreement, or misunderstanding
shall be further reviewed. The Director of DARPA may elect to conduct this review personally or through a designee or jointly
with a senior executive (no lower than Vice President, Legal) appointed by the Performer. Following the review, the Director
of DARPA or designee will resolve the issue(s) and notify the Parties in writing. Such resolution is not subject to further
administrative review and, to the extent permitted by law, shall be final and binding.

 

    	15 of 25

    Agreement HR0011-15-3-0001

    

 

C.       Limitation of Damages

 

Claims for damages of any nature whatsoever pursued under
this Agreement shall be limited to direct damages only up to the aggregate amount of Government funding disbursed as of the time
the dispute arises. In no event shall the Government be liable for claims for consequential, punitive, special and incidental damages,
claims for lost profits, or other indirect damages.

 

ARTICLE VII: PATENT RIGHTS

 

A.       Allocation of Principal Rights

 

Unless the Performer shall have notified DARPA (in accordance
with subparagraph B.2 below) that the Performer does not intend to retain title, the Performer shall retain the entire right, title,
and interest throughout the world to each Subject Invention consistent with the provisions of this Article and 35 U.S.C. §
202. With respect to any Subject Invention in which the Performer retains title, the Government shall have a nonexclusive, nontransferable,
irrevocable, paid-up license to practice or have practiced on behalf of the Government the Subject Invention throughout the world.

 

With regard to Inventions made under this Agreement that are not Subject Inventions,
i.e. Inventions relating to genetically modified organisms, strains, or any compounds or products made by or from such organisms
or strains that are conceived or first actually reduced to practice in the performance of the Program, the Government retains a
right to request from Performer a nonexclusive, nontransferable, irrevocable license, on fair and reasonable terms, to such Inventions
to have such Inventions practiced on behalf of the Government throughout the world. The Government will provide Performer with
written notice identifying the specific Invention to which it is requesting such license. Prior to granting such license, the Parties
agree to negotiate in good faith fair and reasonable terms under which the Performer would be the exclusive supplier/manufacturer
to the Government of the desired compound or product under the Government’s license. Upon agreement of such fair and reasonable
terms between the Performer and the Government, the Performer shall grant the Government the nonexclusive license described above
to such identified Inventions. In the event that no agreement is reached between Performer and Government with regard to said fair
and reasonable terms on Performer’s supply/manufacturing rights, Performer shall nonetheless grant the Government a nonexclusive,
nontransferable, irrevocable license, on fair and reasonable terms, to such Inventions to have such Inventions practiced on behalf
of the Government throughout the world. Failure to reach agreement on fair and reasonable terms will be resolved in accordance
with Article VI. Disputes.

 

B.       Invention Disclosure, Election
of Title, and Filing of Patent Application

 

1.       The
Performer shall disclose each Subject Invention to DARPA within four (4) months after the inventor discloses it in writing to
Performer’s personnel responsible for patent matters or, in the case of no internal writing from the inventor, within
two (2) months after Performer files a provisional application for it; provided however, that in the event the Performer does
not file a provisional application, Performer shall disclose the Subject Invention to the Government within two (2) months of
determining that a particular set of experiments and or data qualify as a Subject Invention. The disclosure to the Government
shall be in the form of a written report and shall identify the Agreement under which the Subject Invention was Made and the
identity of the inventor(s). It shall be sufficiently complete in technical detail to convey a clear understanding to the
extent known at the time of the disclosure, of the nature, purpose, operation, and the physical, chemical, biological, or
electrical characteristics of the Subject Invention. The disclosure shall also identify any publication, sale, or public use
of the Subject Invention and whether a manuscript describing the Subject Invention has been submitted for publication and, if
so, whether it has been accepted for publication at the time of disclosure. The Performer shall also submit to the Government
an annual listing of Subject Inventions.

 

    	16 of 25

    Agreement HR0011-15-3-0001

    

 

2.       If the Performer
determines that it does not intend to retain title to any such Subject Invention, the Performer shall notify the Government, in
writing, within eight (8) months of disclosure to DARPA. However, in any case where publication, sale, or public use has initiated
the one (1)-year statutory period wherein valid patent protection can still be obtained in the United States, the period for such
notice may be shortened by DARPA to a date that is no more than sixty (60) calendar days prior to the end of the statutory period.

 

3.       The Performer
shall file its initial patent application on a Subject Invention to which it elects to retain title within one (1) year after election
of title or, if earlier, prior to the end of the statutory period wherein valid patent protection can be obtained in the United
States after a publication, or sale, or public use. The Performer may elect to file patent applications in additional countries
(including the European Patent Office and the Patent Cooperation Treaty) within either: (i) ten (10) months of the corresponding
initial patent application; or (ii) six (6) months from the date permission is granted by the Commissioner of Patents and Trademarks
to file foreign patent applications where such filing has been prohibited by a secrecy order.

 

4.       Requests
for extension of the time for disclosure, election, and filing under Article VII, paragraph B, may, at the discretion of DARPA,
and after considering the position of the Performer, be granted.

 

C.       Conditions When the Government
May Obtain Title

 

Upon DARPA’s written request, the Performer shall convey
title to any Subject Invention to DARPA under any of the following conditions:

 

1.       If the Performer
fails to disclose or elects not to retain title to the Subject Invention within the times specified in paragraph B of this Article;
provided, that DARPA may request title only within sixty (60) calendar days after learning of: (i) the failure of the Performer
to disclose; or (ii) Performer’s election not to retain title, in each case within the specified times.

 

2.       In those countries
in which the Performer fails to file patent applications within the times specified in paragraph B of this Article; provided, that
if the Performer has filed a patent application in a country after the times specified in paragraph B of this Article, but prior
to its receipt of the written request by DARPA, the Performer shall continue to retain title to the Subject Invention in that country;
or

 

3.       In any country
in which the Performer decides not to continue the prosecution of, to pay the maintenance fees on, or defend a reexamination of
or opposition proceedings on, a patent application or patent on a Subject Invention.

 

D.       Minimum Rights to the Performer
and Protection of the Performer’s Right to File

 

1.       The
Performer shall retain a nonexclusive, royalty-free, paid-up license throughout the world in each Subject Invention to which
the Government obtains title under paragraph C of this Article, except if the Performer fails to disclose the Subject
Invention within the times specified in paragraph B of this Article. The Performer’s license to such Subject Invention
extends to the Performer’s Affiliates and Collaborators, if any, and includes the right to grant sublicenses of the
same scope to the extent that the Performer was legally obligated to do so at the time the Agreement was awarded. The license
is transferable only with the approval of DARPA, except as noted above regarding Affiliates and Collaborators of Performer or
when transferred to the successor of that part of the Performer’s business to which the Subject Invention pertains.
DARPA approval for a license transfer requiring DARPA approval shall not be unreasonably withheld or delayed.

 

    	17 of 25

    Agreement HR0011-15-3-0001

    

 

2.       The Performer’s
license in subparagraph D.1 of this Article may be revoked or modified by DARPA to the extent necessary to achieve expeditious
Practical Application of the Subject Invention pursuant to an application for an exclusive license submitted consistent with appropriate
provisions at 37 CFR Part 404. This license shall not be revoked in that field of use or the geographical areas in which the Performer
continues to practice the general technology developed hereunder in pursuit of commercial goals, including the goal of making the
products derived from such platforms reasonably accessible to the public.

 

3.       Before revocation
or modification of the Performer’s license in subparagraph D.1 of this Article, DARPA shall furnish the Performer a written
notice of its intention to revoke or modify the license, and the Performer shall be allowed thirty (30) calendar days (or such
other time as may be authorized for good cause shown) after the notice to show cause why the license should not be revoked or modified.

 

E.       Action to Protect the Government’s
Interest

 

1.       The Performer
agrees to execute or to have executed and promptly deliver to DARPA all instruments necessary to: (i) establish or confirm the
rights the Government has throughout the world in those Subject Inventions to which the Performer elects to retain title; and (ii)
convey title to DARPA when requested under paragraph D of this Article and to enable the Government to obtain patent protection
throughout the world in that Subject Invention.

 

2.       The Performer
agrees to require, by written agreement, its employees, other than clerical and non-technical employees, to disclose promptly in
writing to personnel identified as responsible for the administration of patent matters and in a format suggested by the Performer
each Subject Invention Made under this Agreement in order that the Performer can comply with the disclosure provisions of paragraph
B of this Article. The Performer shall instruct employees, through employee agreements or other suitable educational programs,
on the importance of reporting Subject Inventions in sufficient time to permit the filing of patent applications prior to U.S.
or foreign statutory bars.

 

3.       The Performer
shall notify DARPA of any decisions not to continue the prosecution of, pay maintenance fees for, or defend in a reexamination
or opposition proceedings on a Subject Invention patent application or patent, in any country, not less than thirty (30) calendar
days before the expiration of the response period required by the relevant patent office.

 

4.       The Performer
shall include, within the specification of any United States patent application and any patent issuing thereon covering a Subject
Invention, the following statement: “This invention was made with Government support under Agreement HR0011-15-3-0001, awarded
by DARPA. The Government has certain rights in the invention.”

 

F.       Lower Tier Agreements

 

The Performer shall include this Article VII, suitably modified
to identify the Parties and, as applicable, Subcontractors, in all subcontracts or lower tier agreements, regardless of tier, for
experimental, developmental, or research work under the Program.

 

    	18 of 25

    Agreement HR0011-15-3-0001

    

 

G.       Reporting on Utilization of Subject
Inventions

 

1.       Pursuant to Attachment
2, the Performer agrees to submit, during the Term, an annual report on the general subject matter research at Performer or its
Collaborators, licensees or assignees in connection with utilization of a Subject Invention or on efforts at obtaining such utilization
that is being made by the Performer or its Collaborators, licensees or assignees. Such reports shall include information regarding
the general fields of potential products where such Subject Inventions may ultimately assist in commercial sales. The Performer
also agrees to provide additional reports as may be requested by DARPA in connection with any march-in proceedings undertaken by
DARPA in accordance with paragraph I of this Article. Consistent with 35 U.S.C. § 202(c) (5), DARPA agrees it shall not disclose
such information to persons outside the Government without permission of the Performer.

 

2.       All required
reporting shall be accomplished, to the extent possible, using the iEdison reporting website: https://s-edison.info.nih.gov/iEdison/.
To the extent any such reporting cannot be carried out by use of i-Edison, reports and communications shall be submitted to the
DARPA Agreements Officer and DARPA Administrative Agreements Officer.

 

H.       Preference for American Industry

 

Notwithstanding any other provision of this clause, the Performer
agrees that it shall not grant to any person the exclusive right to use or sell any Subject Invention in the United States or Canada
unless such person agrees that any product embodying the Subject Invention or produced through the use of the Subject Invention
shall be manufactured substantially in the United States or Canada, except when such rights are in connection with a Collaborator.
However, in individual cases, the requirements for such an agreement beyond what is contemplated herein may be waived by DARPA
upon a showing by the Performer: (1) that reasonable but unsuccessful efforts have been made to grant licenses on similar terms
to potential licensees that would be likely to manufacture substantially in the United States; or (2) that, under the circumstances,
domestic manufacture is not commercially feasible.

 

I.       March-in Rights

 

The Performer agrees that, with respect to any Subject Invention
in which it has retained title, DARPA has the right to require the Performer, an assignee, or exclusive licensee of a Subject Invention
to grant a non-exclusive license to a responsible applicant or applicants, upon terms that are reasonable under the circumstances,
and if the Performer, assignee, or exclusive licensee refuses such a request, DARPA has the right to grant such a license itself
if DARPA determines that:

 

1.       Such action is
necessary because the Performer, assignee, or exclusive licensee has not taken effective steps, consistent with the intent of this
Agreement, to achieve Practical Application of the Subject Invention;

 

2.       Such action is
necessary to alleviate health or safety needs which are not reasonably satisfied by the Performer, assignee, or exclusive licensee;

 

3.       Such action is
necessary to meet requirements for public use and such requirements are not reasonably satisfied by the Performer, assignee, or
exclusive licensee; or

 

4.       Such action is
necessary because the agreement required by paragraph I of this Article has not been obtained or waived or because a licensee of
the exclusive right to use or sell any Subject Invention in the United States is in breach of such agreement.

 

    	19 of 25

    Agreement HR0011-15-3-0001

    

 

ARTICLE VIII: DATA RIGHTS

 

A.       Allocation of Principal Rights

 

1.       This Agreement
shall be performed with mixed Government and Performer funding. The Parties agree that in consideration for Government funding,
the Performer intends to reduce to Practical Application Subject Invention(s) developed under this Agreement.

 

2.       The Performer
agrees to retain and maintain in good condition, until two (2) years after completion or termination of this Agreement, all Data
necessary to achieve Practical Application of Subject Invention(s).

 

3.       In the event of
exercise of the Government’s “March-in Rights” as set forth under Article VII or in this subparagraph, the Performer
agrees that, with respect to Data necessary to achieve Practical Application of the applicable Subject Invention(s), the Government
has the right to require the Performer to deliver, within sixty (60) calendar days from the date of the written request and at
no additional cost to the Government, all such Data to the Government in accordance with its reasonable directions if the Government
determines that:

 

(a)       Such action is
necessary because the Performer, assignee, or exclusive licensee has not taken effective steps, consistent with the intent of this
Agreement, to achieve Practical Application of the Subject Invention(s) developed during the performance of this Agreement;

 

(b)       Such action is
necessary to alleviate health or safety needs which are not reasonably satisfied by the Performer, assignee, or exclusive licensee;
or

 

(c)       Such action is
necessary to meet requirements for public use and such requirements are not reasonably satisfied by the Performer, assignee, or
exclusive licensee.

 

4.       With respect to
all Data delivered in the event of the Government’s exercise of its right under this subparagraph A.3, the Government shall
receive Unlimited Rights.

 

5.        With
respect to Data developed, generated or delivered under this Agreement, the Government shall receive Government Purpose Rights.

 

6. Any data or intellectual property developed or generated exclusively
at private expense, either prior to, or outside the scope of, this Agreement, to be utilized or delivered under this Agreement
by the Performer and/or its Subcontractors shall be delivered with restrictions as delineated in the List of Intellectual Property
Assertions provided in Attachment 5. The Performer reserves the right to add to or modify the data or intellectual property identified
in Attachment 5, but agrees that it will not use in the performance of this Agreement any private expense data or intellectual
property until Attachment 5 is modified to reflect such additional data or intellectual property, in a contractual document executed
by the Contracting Officer.

 

B.       Marking of Data

 

Pursuant to paragraph A above, any Data delivered under this
Agreement shall be marked with the following legend:

 

“Use, duplication, or disclosure is subject to the restrictions
as stated in Agreement HR0011-15-3-0001 between DARPA and Amyris, Inc.”

 

    	20 of 25

    Agreement HR0011-15-3-0001

    

 

C.       Lower Tier Agreements

 

The Performer shall include this Article, suitably modified
to identify the Parties and, as applicable, Subcontractors, in all subcontracts or lower tier agreements, regardless of tier, for
experimental, developmental, or research work under the Program.

 

ARTICLE IX: FOREIGN ACCESS TO TECHNOLOGY

 

This Article shall remain in effect during the Term and for two (2) years thereafter.

 

A.       General

 

The Parties agree that research findings and technology developments
arising under this Agreement may constitute a significant enhancement to the national defense and to the economic vitality of the
United States. Accordingly, access to important technology developments under this Agreement by Foreign Firms or Institutions must
be carefully controlled. The controls contemplated in this Article are in addition to, and are not intended to change or supersede,
the provisions of the International Traffic in Arms Regulation (22 CFR pt. 121 et seq.), the DoD Industrial Security Regulation
(DoD 5220.22-R) and the Department of Commerce Export Regulation (15 CFR pt. 770 et seq.)

 

B.       Restrictions on Sale or Transfer
of Technology to Foreign Firms or Institutions

 

1.       In order to promote
the national security interests of the United States and to effectuate the policies that underlie the regulations cited above,
the procedures stated in subparagraphs B.2 and B.3 below shall apply to any proposed Transfer of Technology. For purposes of this
Article IX, a “Transfer of Technology” means a sale of the Performer or of a Subcontractors, and sales or licensing
of Technology, however, the term “Transfer of Technology” does not include:

 

(a)       sales of products
or components incorporating or produced via a Subject Invention(s), or licenses or sales of any genetically modified organism,
strain, or compound made by or from such an organism, strain, excluding genetically modified organism, strain or compound made
by or from an organism or strain developed under this Program.

 

(b)       licenses of software
or documentation related to sales of products or components described in clause (a), or

 

(c)       a transfer of
Technology to foreign subsidiaries of the Performer for purposes related to this Agreement or to Collaborators, or

 

(d)       a transfer of
Technology to a Foreign Firm or Institution, which is a Subcontractor or an approved source of supply or source for the conduct
of research under this Agreement; provided that such transfer shall be limited to that necessary to allow the Foreign Firm or Institution
to perform its approved role under this Agreement.

 

2.       The
Performer shall provide written notice to the DARPA Agreements Officer’s Representative and DARPA Agreements Officer of
any proposed Transfer of Technology to a Foreign Firm or Institution by Performer or a Subcontractor at least sixty (60)
calendar days prior to the proposed date of transfer. Such notice shall cite this Article and shall state specifically what
Technology is to be transferred and the general terms of the transfer. Within thirty (30) calendar days of receipt of the
Performer’s written notification, the DARPA Agreements Officer shall advise the Performer whether it consents to the
proposed Transfer. If DARPA determines that the proposed Transfer of Technology may have adverse consequences to the national
security interests of the United States, the Performer (or, if applicable, a Subcontractor) and DARPA shall jointly endeavor
to find alternatives to the proposed Transfer of Technology which obviate or mitigate potential adverse consequences of the
Transfer of Technology but which provide substantially equivalent benefits to the Performer (or, if applicable, a
Subcontractor). In cases where DARPA does not concur or sixty (60) calendar days after receipt and DARPA provides no
decision, the Performer (or, if applicable, Performer on behalf of a Subcontractor) may utilize the procedures under Article
VI, Disputes. No such Transfer shall take place until a decision is rendered.

 

    	21 of 25

    Agreement HR0011-15-3-0001

    

 

3.       In the event a
Transfer of Technology to a Foreign Firm or Institution which is NOT approved by DARPA takes place, the Performer shall: (a) refund
to DARPA funds paid by DARPA for the development of such unapproved transferred Technology; and (b) the Government shall have a
non-exclusive, nontransferable, irrevocable, paid-up license to practice or have practiced on behalf of the Government such Technology
throughout the world for the Government and any and all other purposes, particularly to effectuate the intent of this Agreement.
Upon request of the Government, the Performer shall provide written confirmation of such licenses.

 

C.       Lower Tier Agreements

 

The Performer shall include this Article, suitably modified
to identify the Parties and, as applicable, Subcontractors, in all subcontracts or lower tier agreements, regardless of tier, for
experimental, developmental, or research work under the Program.

 

ARTICLE X: TITLE TO AND DISPOSITION OF PROPERTY

 

A.       Title to Property

 

Title to any items of Property acquired under this Agreement
with an acquisition value of $5,000 or less shall vest in the Performer (and/or its Subcontractors) upon acquisition with no further
obligation of the Parties unless otherwise determined in advance by the DARPA Agreements Officer. The Performer (and/or its Subcontractors)
will acquire Property with an acquisition value greater than $5,000 under this Agreement as set forth in Attachment 6 to this Agreement,
which Property is necessary to further the research and development goals of this Program and is not for the direct benefit of
the Government. Title to this Property shall vest in the Performer (and/or its Subcontractors) upon acquisition. Should any other
item of Property with an acquisition value greater than $5,000 be required during the Program, the Performer shall obtain prior
written approval of the DARPA Agreements Officer, which approval shall not to be unreasonably withheld or delayed. Title to this
later acquired Property shall also vest in the Performer (and/or its Subcontractors) upon acquisition. The Performer (and/or its
Subcontractors) shall be responsible for the maintenance, repair, protection, and preservation of all such Property at its own
expense.

 

B.       Disposition of Property with Value
>$5,000

 

At the completion or termination of the Term, title to (i) items of
Property set forth in Attachment 6 and (ii) any other items of Property acquired under the Program with an acquisition value greater
than $5,000 shall remain vested with the Performer and, if applicable, its Subcontractors without further obligation to the Government.

 

 

    	22 of 25

    Agreement HR0011-15-3-0001

    

 

ARTICLE XI: CIVIL RIGHTS ACT

 

This Agreement is subject to the compliance requirements of
Title VI of the Civil Rights Act of 1964 as amended (42 U.S.C. 2000-d) relating to nondiscrimination in Federally assisted programs.
The Performer has signed a Certifications for Agreement No. HR0011-15-3-0001, a copy of which is attached hereto as Attachment
7, which certifies, among other matters, the Performer’s compliance with the nondiscriminatory provisions of the Act.

 

ARTICLE XII: SECURITY

 

The Government does not anticipate the need for the Performer
(or its Subcontractors) to develop and/or handle classified information in the performance of this Agreement. No DD254 is currently
required for this Agreement.

 

ARTICLE XIII: SUBCONTRACTORS

 

The Performer shall make every effort to satisfy the intent
of competitive bidding of sub-agreements to the maximum extent practical. The Performer may use foreign entities or nationals as
Subcontractors, subject to compliance with the requirements of this Agreement and to the extent otherwise permitted by law.

 

ARTICLE XIV: KEY PERSONNEL

 

A.       The Performer shall notify the DARPA
Agreements Officer in writing prior to making any change in Key Personnel for the Program. The following individuals are designated
as ”Key Personnel” for the purposes of this Agreement:

 

	Name	Role/Title	% Time
	 	Principal Investigator (PI)	100%
	 	Co-PI	100%

 

B.       When replacing any of the Key Personnel
identified above, the Performer must demonstrate that the qualifications of the prospective Key Personnel are acceptable to the
Government as reasonably determined by the Program Manager. Substitution of Key Personnel shall be documented by modification to
the Agreement made in accordance with the procedures outlined in Article III, paragraph C.

 

ARTICLE XV: ORDER OF PRECEDENCE

 

In the event of any inconsistency between the terms of this
Agreement and language set forth in the Attachments, the inconsistency shall be resolved by giving precedence in the following
order: (1) the Agreement; and (2) all Attachments to the Agreement.

 

ARTICLE XVI: EXECUTION

 

This Agreement constitutes the entire agreement of the
Parties with respect to the subject matter hereof and supersedes all prior and contemporaneous agreements, understandings,
negotiations and discussions among the Parties, whether oral or written, with respect to the subject matter hereof. This
Agreement may be revised only by written consent of the Performer and the DARPA Agreements Officer. This Agreement, or
modifications thereto, may be executed in counterparts each of which shall be deemed as original, but all of which taken
together shall constitute one and the same instrument.

 

 

    	23 of 25

    Agreement HR0011-15-3-0001

    

 

ARTICLE XVII: APPLICABLE LAW

 

United States federal law will apply to the construction,
interpretation, and resolution of any disputes arising out of or in connection with this Agreement.

 

ARTICLE XIII: SEVERABILITY

 

In the event that any one or more of the provisions contained
herein shall, for any reason, be held to be invalid, illegal or unenforceable in any respect, such invalidity, illegality or unenforceability
shall not affect any other provisions of this Agreement, but this Agreement shall be construed as if such invalid, illegal or unenforceable
provisions had never been contained herein, unless the deletion of such provision or provisions would result in such a material
change so as to cause completion of the transactions contemplated herein to be unreasonable.

 

ARTICLE XIX: DATA SHARING PLAN AND STATUS REPORTING

 

It is the goal of the Government that its investment in
the tools and capabilities developed under the Program to be multiplied many-fold by adoption and improvement by researchers across
the United States. In order to achieve this vision, the Living Foundries program aims to facilitate interoperability and open the
field to new entrants.

 

The Performer shall make available the Tools developed
under the Program to the broader synthetic biology community by presenting its Program research Data at public meetings, conferences,
and workshops and publishing results in peer-reviewed journal articles. At a minimum, the types of information that will be made
available to the broader synthetic biology community are as discussed below:

 

(i) Data and analysis necessary to evaluate the utility of the Tools
developed under the Program, including standard operating procedures and design specifications enabling others to reconstitute
the equipment, set up, and approaches developed.

 

(ii) Details required for technical evaluation
of the Tools developed under the Program: full protocols, technical drawings of equipment built and specifications met, Data on
accuracy and precision of these systems, and results of procedures performed against large number of samples to investigate the
robustness and readiness of the approaches for broader distribution – providing a trained reader with the information needed
to recapitulate the methods and results described.

 

(iii) The Key Personnel shall be reasonably available
to consult with third parties seeking to replicate the results.

 

The Performer shall include as part of required monthly Technical
Status Reports in Attachment 2 an on-going status of efforts to develop and/or carry out this Intellectual Property and Data Sharing
plan. Reporting shall include a summary of Data sharing activities that have taken place during the reporting period, and any Data
sharing activities planned to take place within three months of the reporting period.

 

    	24 of 25

    Agreement HR0011-15-3-0001

    

 

The Performer shall also include as part of required monthly Technical Status Reports
in Attachment 2 a listing of the Performer’s Subject Invention disclosures, Subject Invention patent applications and a brief
discussion summarizing plans, if any, to license the resulting Subject Inventions (e.g., intent and rationale regarding whether
the Performer intends to seek non-exclusive licensing, exclusive licensing for a particular field of use, or exclusive licensing
across the board, etc.).

 

 

 

 

 

 

 

 

 

    	25 of 25

    
HR0011-15-3-0001

    

 

Attachment 3

 

Total Agreement Funding Plan and Payable Milestones and Corresponding
Payment Schedule

Revision 1

 

Total Agreement Funding Plan

(for informational purposes only)

 

	 	DARPA Payment Total	Performer Contribution $	
        Agreement Funding

        Grand Total
	
        DARPA Share 

        %
	Performer Contribution %
	Module A Total	$11,267,168 	$1,238,563 	$12,505,727 	90.10%	9.90%
	Module B Total	$4,517,217 	$767,829 	$5,285,046 	85.47%	14.53%
	Module C Total	$1,065,228 	$565,813 	$1,631,041 	65.31%	34.69%
	Module D Total	$2,532,939 	$1,003,490 	$3,536,429 	71.62%	28.38%
	Module E Total	$1,183,490 	$1,939,053 	$3,122,543 	37.90%	62.10%
	Module F Total	$1,054,407 	$767,829 	$1,822,236 	57.86%	42.14%
	Module G Total	DELETED
	Module H Total	$5,895,752 	$3,831,230 	$9,726,982 	60.61%	39.39%
	Module I Total	$1,462,441 	$1,775,450 	$3,237,891 	45.17%	54.83%
	Module J Total	$3,000,887 	$2,517,831 	$5,518,718 	54.38%	45.62%
	Module K Total	$3,180,481 	$1,154,251 	$4,334,731 	73.37%	26.63%
	 	$35,160,011 	$15,561,338 	$50,721,349 	69.32%	30.68%

 

 

     

    
HR0011-15-3-0001

    

 

Payable Milestones and Corresponding Payment Schedule

 

	Payable Milestones	Task	Metric	Government Payment due the Performer upon Completion	MS Month	CLIN/SLIN/ACRN
	1	[*]	[*]

                                                                                 
	[*]	1/31/16	0001/01/AA
	2	[*]	[*]

                                                                                 
	[*]	0001/01/AA
	[*]	[*]

                                                                               

	[*]	[*]

                                                                               

	3	[*]	[*]

                                                                                 
	[*]	0001/01/AA
	4	[*]	[*]

                                                                                 
	[*]	0001/01/AA
	5	[*]	[*]

                                                                                 
	[*]	0001/01/AA
	6	[*]	[*]

                                                                                 
	[*]	4/30/16	0001/01/AA
	[*]	[*]

                                                                               

 

 

 

 

 

 

 

 

 

 

[*] Certain portions denoted with an asterisk have been omitted
and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the
omitted portions.

 

     

    
HR0011-15-3-0001

    

 

	 	 	[*]

                                                                                 
	 	 	 
	[*]	[*]

                                                                               

	 	[*]	[*]

                                                                                 
	[*]	 
	[*]	[*]

                                                                               

	[*]	[*]

                                                                               

	8	[*]	[*]

                                                                                 
	[*]	0001/01/AA

 

 

 

 

 

 

 

 

 

 

 

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.      

 

     

    
HR0011-15-3-0001

    

 

	9	[*]	[*]

                                                                                 
	[*]	 	0001/01/AA
	10	[*]	[*]

                                                                                 
	[*]	0001/01/AA
	[*]	[*]

                                                                               

	11	[*]	[*]

                                                                                 
	[*]	0001/01/AA
	12	[*]	[*]

                                                                                 
	[*]	0001/01/AA
	13	[*]	[*]

                                                                                 
	[*]	0001/01/AA

 

 

 

 

 

 

 

 

[*] Certain portions denoted with an asterisk have been omitted
and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the
omitted portions.

 

     

    
HR0011-15-3-0001

    

 

	 	 	[*]

                                                                                 
	 	 	 
	14	[*]	[*]

                                                                                 
	[*]	7/31/16	0001/01/AA
	[*]	[*]

                                                                               

	15	[*]	[*]

                                                                                 
	[*]	0001/01/AA
	[*]	[*]

                                                                               

	[*]	[*]

                                                                               

	16	[*]	[*]

                                                                                 
	[*]	0001/01/AA
	17	[*]	[*]	[*]	
         

         

        0001/01/AA

 

 

 

 

 

 

 

 

[*] Certain portions denoted with an asterisk have been omitted
and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the
omitted portions.

 

     

    
HR0011-15-3-0001

    

 

	 	[*]	[*]

                                                                                 
	 	 	 
	18	[*]	[*]

                                                                                 
	[*]	0001/01/AA
	19	[*]	[*]

                                                                                 
	[*]	10/31/16	0001/01/AA
	20	[*]	[*]

                                                                                 
	[*]	0001/01/AA
	[*]	[*]

                                                                               

	[*]	[*]

                                                                               

	[*]	[*]

                                                                               

	21	[*]	[*]

                                                                                 
	[*]	0001/01/AA

 

 

 

 

 

 

 

 

 

[*] Certain portions denoted with an asterisk have been omitted
and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the
omitted portions.

 

     

    
HR0011-15-3-0001

    

 

	 	[*]	[*]

                                                                                 
	 	 	 
	[*]	[*]

                                                                               

	[*]	[*]

                                                                               

	22	[*]	[*]

                                                                                 
	[*]	0001/01/AA
	23	[*]	[*]

                                                                                 
	[*]	0001/01/AA
	24	[*]	[*]

                                                                                 
	[*]	0001/01/AA

 

 

 

 

 

 

 

 

 

 

[*] Certain portions denoted with an asterisk have been omitted
and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the
omitted portions.

 

     

    
HR0011-15-3-0001

    

 

	 	[*]	[*]

                                                                                 
	[*]	 	 
	25	[*]	[*]

                                                                                 
	[*]	0001/01/AA
	[*]	[*]

                                                                               

	[*]	[*]

                                                                               

	26	[*]	[*]

                                                                                 
	[*]	0001/01/AA
	27	[*]	[*]

                                                                                 
	[*]	0001/01/AA
	[*]	[*]

                                                                               

 

 

 

 

 

 

 

 

 

 

[*] Certain portions denoted with an asterisk have been omitted
and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the
omitted portions.

 

     

    
HR0011-15-3-0001

    

 

	28	[*]	[*]

                                                                                 
	[*]	 	0001/01/AA
	29	[*]	[*]

                                                                                 
	[*]	1/31/17	0001/01/AA
	30	[*]	[*]

                                                                                 
	[*]	4/30/17	0001/01/AA
	31	[*]	[*]

                                                                                 
	[*]	0001/01/AA
	[*]	[*]

                                                                               

	32	[*]	[*]

                                                                                 
	[*]	0001/01/AA
	33	[*]	[*]

                                                                                 
	[*]	0001/01/AA

 

 

 

 

 

 

 

 

 

[*] Certain portions denoted with an asterisk have been omitted
and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the
omitted portions.

 

     

    
HR0011-15-3-0001

    

 

	 	 	[*]

                                                                                 
	 	 	 
	[*]	[*]

                                                                               

	[*]	[*]

                                                                               

	34	[*]	[*]

                                                                                 
	[*]	0001/01/AA
	[*]	[*]

                                                                               

	[*]	[*]

                                                                               

 

 

 

 

 

 

 

 

 

[*] Certain portions denoted with an asterisk have been omitted
and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the
omitted portions.

 

     

    
HR0011-15-3-0001

    

 

	35	[*]	[*]	[*]	 	0001/01/AA
	36	[*]	[*]	[*]	0001/01/AA
	37	[*]	[*]	[*]	0001/01/AA
	38	[*]	[*]	[*]	0001/01/AA
	[*]	[*]
	39	[*]	[*]	[*]	
        0001/01/AA

        (Partially funded @ $315,985 at time of TIA Award)

	40	[*]	[*]	[*]	7/31/17	 
	[*]	[*]

 

 

 

 

 

 

 

 

 

[*] Certain portions denoted with an asterisk have been omitted
and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the
omitted portions.

 

     

    
HR0011-15-3-0001

    

 

	 	[*]	[*]	 	 	 
	[*]	[*]
	41	[*]	[*]	[*]	 
	42	[*]	[*]	[*]	 
	43	[*]	[*]	[*]	4/30/18	 
	44	[*]	[*]	[*]	 
	[*]	[*]
	[*]	[*]
	[*]	[*]
	45	[*]	[*]	[*]	 

 

 

 

 

 

 

 

[*] Certain portions denoted with an asterisk have been omitted
and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the
omitted portions.

 

     

    
HR0011-15-3-0001

    

 

	 	[*]	[*]	 	 	 
	[*]	[*]
	[*]	[*]
	46	[*]	[*]	[*]	 
	[*]	[*]
	[*]	[*]
	47	[*]	[*]	[*]	 
	[*]	[*]

 

 

 

 

 

 

 

 

 

[*] Certain portions denoted with an asterisk have been omitted
and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the
omitted portions.

 

     

    
HR0011-15-3-0001

    

 

	 	 	[*]	 	 	 
	48	[*]	[*]	[*]	 
	49	[*]	[*]	[*]	 
	50	[*]	[*]	[*]	 
	51	[*]	[*]	[*]	 
	[*]	[*]
	[*]	[*]
	52	[*]	[*]	[*]	 
	[*]	[*]

 

 

 

 

 

 

 

 

 

[*] Certain portions denoted with an asterisk have been omitted
and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the
omitted portions.

 

     

    
HR0011-15-3-0001

    

 

	 	 	[*]	 	 	 
	53	[*]	[*]	[*]	 
	54	[*]	[*]	[*]	 
	[*]	[*]
	55	[*]	[*]	[*]	 
	56	[*]	[*]	[*]	7/31/18	 
	57	[*]	[*]	[*]	10/31/18	 
	58	[*]	[*]	[*]	 
	[*]	[*]
	59	[*]	[*]	[*]	 

 

 

 

 

 

 

 

 

 

[*] Certain portions denoted with an asterisk have been omitted
and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the
omitted portions.

 

     

    
HR0011-15-3-0001

    

 

	 	 	[*]	 	 	 
	60	[*]	[*]	[*]	 
	61	[*]	[*]	[*]	4/30/19	 
	62	[*]	[*]	[*]
	OPTION 63	[*]	[*]	[*]
	64	[*]	[*]	[*]	7/31/19	 
	OPTION 65	[*]	[*]	[*]	10/31/19	 
	66	[*]	[*]	[*]	 

 

 

 

 

 

 

 

 

 

[*] Certain portions denoted with an asterisk have been omitted
and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the
omitted portions.

 

     

    
HR0011-15-3-0001

    

 

	 	 	[*]

                                                                                 
	 	 	 
	 	 	Baseline Costs	$34,167,843	 	 
	 	 	Option Costs	$992,168	 	 
	 	 	TOTAL	$35,160,011	 	 

 

 

 

 

 

 

 

 

 

[*] Certain portions denoted with an asterisk have been omitted
and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the
omitted portions.

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00269-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00269-of-00352.parquet"}]]