Document:

EX-10.2

 Exhibit 10.2 

EXCHANGE AGREEMENT 
 This
Exchange Agreement (the “Agreement”) is entered into as of the      day of May, 2020, by and between Tyme Technologies, Inc., a Delaware corporation (the “Company”), and the undersigned holder of
the Existing Warrant (as defined below) (the “Holder”), with reference to the following facts: 
 A. The Holder has
previously acquired that certain Warrant to Purchase Common Stock (the “Existing Warrant”) currently exercisable into such aggregate number of shares of Common Stock as set forth on the signature page of the holder attached hereto;

 B. The Company has duly authorized the issuance to the Holder, in exchange for the Existing Warrant, a new warrant in the form attached
hereto as Exhibit A (the “Exchange Warrant”); 
 C. Each of the Company and the Holder desire to effectuate such exchange
on the basis and subject to the terms and conditions set forth in this Agreement; 
 D. The exchange of the Existing Warrant for the
Exchange Shares is being made in reliance upon the exemption from registration provided by Section 3(a)(9) of the Securities Act of 1933, as amended (the “Securities Act”); 

E. Concurrently herewith, the Company is separately negotiating, and intends to implement, the exchange of warrants to purchase Common Stock
issued in the same underwritten offering as the Existing Warrant (the “Other Warrants”) that are currently outstanding and held by one or more other Purchasers (the “Other Holders”) into shares of Common Stock (the
“Other Exchange Shares”); 
 F. The Other Holders intend to exchange the Other Warrants by entering into agreements (the
“Other Agreements”) in the same form as this Agreement (other than changes based on the exchange for an Exchange Warrant or Common Stock, proportional changes based upon the difference in aggregate number of shares of Common Stock
issuable upon exercise of the remaining Other Warrants outstanding, and the payment of legal expenses with respect hereto and changes necessitated by an exchange of a Warrant for Other Exchange Shares); and 

G. Capitalized terms used but not otherwise defined herein shall have the meaning as set forth in the Existing Warrant. 

NOW, THEREFORE, in consideration of the foregoing premises and the mutual covenants hereinafter contained, the parties hereto agree as
follows: 
 1.    Exchange 

(a)    On the Effective Date (as defined below), pursuant to Section 3(a)(9) of the Securities Act, the Holder hereby
agrees to convey, assign and transfer the Existing Warrant to the Company in exchange for which the Company agrees to issue the Exchange Warrant to the Holder (the “Exchange”). Upon exercise of all or a portion of the Exchange
Warrant in accordance with the terms of the Exchange Warrant, such shares of Common Stock (the “Exchange Shares”) shall be issued without a securities laws restrictive legend and shall be freely tradable by the Holder, 

 
provided, however the Holder and the Exchange Shares shall be subject to the contractual obligations of the Leak-Out Agreement (as defined
below) and, to the extent the Exchange Shares have not been sold by the Holder in compliance with the Leak-Out Agreement, the Holder agrees to keep such Exchange Shares in a segregated account (which account,
for the avoidance of doubt, may also hold other securities issued by other entities)(the “Holder Account”) at a bank, investment bank, broker-dealer or other similar financial institution (the “Holder Account
Bank”). From time to time, but not in excess of twice in any trailing 30 day period, the Company may request in writing to the Holder for a copy of the statement of the aggregate number of Exchange Shares held in the Holder Account provided
by the Holder Account Bank (each, a “Holder Account Statement”). The Holder shall, as soon as commercially practical after receipt of such request, but in no event later than the third
(3rd) Trading Day after such request, deliver such Holder Account Statement to the Company. For the avoidance of doubt, the Company acknowledges that each Holder Account Statement shall be
redacted with respect to any securities both held in the Holder Account and not issued by the Company. As soon as commercially practicable following the Effective Date, the Holder shall deliver or cause to be delivered to the Company (or its
assignee) the Existing Warrant (or affidavit of lost warrant, in form provided upon request by the Company and reasonably acceptable to the Holder). Concurrently with delivery of the Exchange Shares to the Holder (or its assignee), the Holder hereby
relinquishes all rights, title and interest in the Existing Warrant (including any claims the Holder may have against the Company related thereto) and assigns the same to the Company and the Existing Warrant shall be cancelled. Concurrently
herewith, the Holder has executed and delivered to the Company the leak-out agreement, in the form attached hereto as Exhibit B (the “Leak-Out
Agreement”). 
 (b) The Company and the Holder shall execute and/or deliver such other documents and agreements as are customary
and reasonably necessary to effectuate the Exchange. 
 2.    Company Representations and Warranties.
The Company represents and warrants to the Holder, and covenants for the benefit of the Holder, as follows: 
 (a) The Company has been
duly incorporated and is validly existing and in good standing under the laws of the state of Delaware, with full corporate power and authority to own, lease and operate its properties and to conduct its business as currently conducted, and is duly
registered and qualified to conduct its business and is in good standing in each jurisdiction or place where the nature of its properties or the conduct of its business requires such registration or qualification, except where the failure to
register or qualify would not have a Material Adverse Effect. For purposes of this Agreement, “Material Adverse Effect” shall mean any material adverse effect on the business, operations, properties, prospects, or financial
condition of the Company and its subsidiaries and/or any condition, circumstance, or situation that would prohibit or otherwise materially interfere with the ability of the Company to perform any of its obligations under this Agreement in any
material respect. 
 (b) The issuance of the Exchange Warrant is duly authorized and, upon issuance in accordance with the terms hereof and
the Exchange Warrant, the Exchange Shares shall be validly issued, fully paid and non-assessable and free from all preemptive or similar rights, taxes, liens and charges and other encumbrances with respect to
the issue thereof and the Exchange Shares shall be fully paid and nonassessable with the holder thereof being entitled to all rights accorded to a holder of Common Stock. No commission or other remuneration has been paid by the Holder to the Company
in connection with the Exchange or any transactions contemplated hereby. 

  
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 (c) This Agreement, the Exchange Warrant and the
Leak-Out Agreement have been duly authorized, validly executed and delivered on behalf of the Company and each is a valid and binding agreement and obligation of the Company enforceable against the Company in
accordance with its terms, subject to limitations on enforcement by general principles of equity and by bankruptcy or other laws affecting the enforcement of creditors’ rights generally, and the Company has full power and authority to execute
and deliver the Agreement, the Exchange Warrant, the Leak-Out Agreement and the other agreements and documents contemplated hereby and to perform its obligations hereunder and thereunder. 

(d) The execution and delivery of the Agreement, the Exchange Warrant, the Leak-Out Agreement and the
consummation of the transactions contemplated by this Agreement, the Exchange Warrant, and the Leak-Out Agreement by the Company, will not (i) conflict with or result in a breach of or a default under any
of the terms or provisions of, (A) the Company’s certificate of incorporation or by-laws, or (B) of any material provision of any indenture, mortgage, deed of trust or other material agreement
or instrument to which the Company is a party or by which it or any of its material properties or assets is bound, (ii) result in a violation of any provision of any law, statute, rule, regulation, or any existing applicable decree, judgment or
order by any court, Federal or state regulatory body, administrative agency, or other governmental body having jurisdiction over the Company, or any of its material properties or assets or (iii) result in the creation or imposition of any
material lien, charge or encumbrance upon any material property or assets of the Company or any of its subsidiaries pursuant to the terms of any agreement or instrument to which any of them is a party or by which any of them may be bound or to which
any of their property or any of them is subject, except in the case of clauses (i)(B), (ii) or (iii) for any such conflicts, breaches, or defaults or any liens, charges, or encumbrances which would not have a Material Adverse Effect. 

(e) Assuming the accuracy of the representations and warranties of the Holder contained herein, the Exchange is exempt from registration under
the Securities Act, pursuant to the exemption provided by Section 3(a)(9) thereof, and applicable state securities laws. 
 (f) No
consent, approval or authorization of or designation, declaration or filing with any governmental authority on the part of the Company is required in connection with the valid execution and delivery of this Agreement or the offer, sale or issuance
of the Exchange Warrant or the consummation of any other transaction contemplated by this Agreement. 
 (g) The Company has complied and
will comply with all applicable federal and state securities laws in connection with the offer, issuance and delivery of the Exchange Warrant hereunder. Neither the Company nor anyone acting on its behalf, directly or indirectly, has or will sell,
offer to sell or solicit offers to buy any of the Exchange Warrant or Exchange Shares, or similar securities to, or solicit offers with respect thereto from, or enter into any preliminary conversations or negotiations relating thereto with, any
person, or has taken or will take any action so as to bring the issuance and sale of any of the Exchange Warrant or Exchange Shares under the registration provisions of the Securities Act and applicable state securities laws. Neither the Company nor
any of its affiliates, nor any person acting on its or their behalf, has engaged in any form of general solicitation or general advertising (within the meaning of Regulation D under the Securities Act) in connection with the offer or sale of any of
the Exchange Warrant or Exchange Shares. 

  
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 (h) There is no action, suit, proceeding, or, to the knowledge of the Company, inquiry or
investigation, before or any court, public board, government agency, self-regulatory organization or body pending or, to the knowledge of the Company, threatened against or affecting the Company or any of its Subsidiaries, the Common Stock or any of
the Company’s Subsidiaries or any of the Company’s or its Subsidiaries’ officers or directors, whether of a civil or criminal nature or otherwise, in their capacities as such. 

(i) The Company represents that it has not paid, and shall not pay, any commissions or other remuneration, directly or indirectly, to any
third party for the solicitation of the Exchange. Other than the exchange of the Existing Warrants, the Company has not received any consideration for the Exchange Warrant or Exchange Shares. 

3.    Holder Representations and Warranties. 

(a) This Agreement, the Exchange Warrant and the Leak-Out Agreement have been duly authorized, validly
executed and delivered by the Holder and each is a valid and binding agreement and obligation of the Holder, enforceable against the Holder in accordance with their respective terms, subject to limitations on enforcement by general principles of
equity and by bankruptcy or other laws affecting the enforcement of creditors’ rights generally, and the Holder has full power and authority to execute and deliver the Agreement, the Leak-Out Agreement
and the other agreements and documents contemplated hereby and to perform its obligations hereunder and thereunder. 
 (b) The Holder
understands that the Exchange Warrant is being offered and sold in reliance on specific provisions of Federal and state securities laws, specifically Section 3(a)(9) of the Securities Act, and that the Company is relying upon the truth and
accuracy of the representations, warranties, agreements, acknowledgments and understandings of the Holder set forth herein for purposes of qualifying for exemptions from registration under the Securities Act and applicable state securities laws.

 (c) The Holder owns and holds, beneficially and of record, the entire right, title, and interest in and to the Existing Warrant free and
clear of all rights and Liens (as defined below). The Holder has the full power and authority to vote, transfer and dispose of the Existing Warrant free and clear of any right or Encumbrance other than restrictions under the Securities Act and
applicable state securities laws. Other than the transactions contemplated by this Agreement, there is no outstanding vote, plan, pending proposal, or other right of any person to acquire all or any of the Existing Warrant. As used herein,
“Liens” shall mean any security or other property interest or right, claim, lien, pledge, option, charge, security interest, contingent or conditional sale, or other title claim or retention agreement, interest or other right or
claim of third parties, whether perfected or not perfected, voluntarily incurred or arising by operation of law, and including any agreement (other than this Agreement) to grant or submit to any of the foregoing in the future. 

(d) The execution, delivery and performance by the Holder of this Agreement, the Exchange Warrant and the
Leak-Out Agreement, and the consummation by the Holder of the transactions contemplated hereby and thereby will not (i) result in a violation of the organizational documents of the Holder,
(ii) conflict with or result in a breach of or default (or an event which with notice or lapse of time or both would become a default) under, or give to others any rights of termination, amendment, acceleration or cancellation of, any
agreement, indenture or instrument to which the Holder is a party, or (iii) result in a violation of any law, rule, regulation, order, 

  
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judgment or decree (including federal and state securities laws) applicable to the Holder, except in the case of clauses (ii) and (iii) above, for such conflicts, defaults, rights or
violations which would not, individually or in the aggregate, reasonably be expected to have a material adverse effect on the ability of the Holder to perform its obligations hereunder. 

(e) The Holder is acquiring the Exchange Warrant in the ordinary course of its business. The Holder has such knowledge, sophistication, and
experience in business and financial matters so as to be capable of evaluation of the merits and risks of the prospective investment in the Exchange Warrant, and has so evaluated the merits and risk of such investment. The Holder is an
“accredited investor” as defined in Regulation D under the Securities Act. 
 (f) To Holder’s knowledge, Holder is not an
“affiliate” of the Company (as defined in Rule 144 under the Securities Act) or the “beneficial owner” of more than 10% of the Company’s outstanding common stock (as that term is defined under the Exchange Act). Other than
the Existing Warrants, the Holder is the beneficial owner of                  shares of outstanding Company common stock. 

(g) Holder has been given full and adequate access to information relating to the Company, including its business, finances and operations as
Holder has deemed necessary or advisable in connection with Holder’s evaluation of the Exchange. Holder has not relied upon any representations or statements made by either the Company or its agents, officers, directors, employees or
stockholders in regard to this Agreement or the basis thereof. Holder has had the opportunity to review the Company’s filings with the Securities and Exchange Commission. Holder and its advisors, if any, have been afforded the opportunity to
ask questions of the Company. Holder understands that its investment in the Exchange Warrant involves a high degree of risk. Holder has sought such accounting, legal and tax advice as it has considered necessary to make an informed investment
decision with respect to its acquisition of the Exchange Warrant. Holder is relying solely on its own accounting, legal and tax advisors, and not on any statements of the Company or any of its agents or representatives, for such accounting, legal
and tax advice with respect to its acquisition of the Exchange Warrant and the transactions contemplated by this Agreement. 
 (h) Holder
acknowledges that the terms of the Exchange have been established by negotiation between the Company and the Holders. Holder acknowledges that the Company has not made any representation to such Holder about the advisability of this decision or the
potential future value of the Existing Warrants. HOLDER ACKNOWLEDGES THAT, BY EXCHANGING THE EXISTING WARRANTS FOR THE EXCHANGE WARRANT PURSUANT TO THIS AGREEMENT, SUCH HOLDER WILL NOT BENEFIT FROM ANY FUTURE APPRECIATION IN THE MARKET VALUE OF THE
EXISTING WARRANT. 
 4.    Disclosure of Transaction. The Company shall, on or before 9:30 a.m., New York
City time, on or prior to the first business day after the date of this Agreement, file a Current Report on Form 8-K describing the terms of the transactions contemplated hereby in the form required by the
1934 Act and attaching the form of this Agreement as an exhibit to such filing (including all attachments, the “8-K Filing”). The Company shall file its Annual Report on Form 10-K on or prior to the date such filing is due under applicable securities laws (the “10-K Filing”). From and after the filing of the 10-K Filing, the Company shall have disclosed all material, non-public information (if any) provided up to such time to the Holder by the Company or any of its Subsidiaries or
any of their respective officers, directors, employees, affiliates or agents, that is 

  
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not disclosed in the 8-K Filing or 10-K Filing. The Company shall not, and shall cause its officers, directors,
employees, affiliates and agents, not to, provide the Holder with any material, nonpublic information regarding the Company from and after the filing of the 10-K Filing without the express written consent of
the Holder. To the extent that the Company delivers any material, non-public information to the Holder without the Holder’s express prior written consent, the Company hereby covenants and agrees that the
Holder shall not have any duty of confidentiality to the Company, any of its Subsidiaries or any of their respective officers, directors, employees, affiliates or agent with respect to, or a duty to the to the Company, any of its Subsidiaries or any
of their respective officers, directors, employees, affiliates or agent or not to trade on the basis of, such material, non-public information. The Company shall not disclose the name of the Holder in any
filing, announcement, release or otherwise, unless such disclosure is required by law or regulation. In addition, effective upon the filing of the 10-K Filing, the Company acknowledges and agrees that any and
all confidentiality or similar obligations under any agreement with respect to the transactions contemplated by this Agreement or as otherwise disclosed in the 8-K Filing or
10-K Filing, whether written or oral, between the Company, any of its Subsidiaries or any of their respective officers, directors, affiliates, employees or agents, on the one hand, and any of the Holder or any
of their affiliates, on the other hand, shall terminate. Neither the Company, its Subsidiaries nor the Holder shall issue any press releases or any other public statements with respect to the transactions contemplated hereby; provided,
however, the Company shall be entitled, without the prior approval of the Holder, to make a press release or other public disclosure with respect to such transactions (i) in substantial conformity with the 8-K Filing or (ii) as is required by applicable law and regulations (provided that in the case of clause (i) the Holder shall be consulted by the Company in connection with any such press release or other
public disclosure prior to its release). Without the prior written consent of the Holder (which may be granted or withheld in the Holder’s sole discretion), except as required by applicable law, the Company shall not (and shall cause each of
its Subsidiaries and affiliates to not) disclose the name of the Holder in any filing, announcement, release or otherwise. 

5.    No Integration. None of the Company, its Subsidiaries, any of their affiliates, or any Person acting
on their behalf shall, directly or indirectly, make any offers or sales of any security (as defined in the Securities Act) or solicit any offers to buy any security or take any other actions, under circumstances that would require registration of
the Exchange Warrant under the Securities Act or cause this offering of the Exchange Shares to be integrated with such offering or any prior offerings by the Company for purposes of Regulation D under the Securities Act. 

6.    Section 3(a)(9) Exchange; Holding Period. The parties acknowledge and agree that the Exchange
is being completed in accordance with Section 3(a)(9) of the Securities Act and, as the Existing Warrants were originally issued in a registered offering, the Exchange Warrant issued in exchange therefor shall take on the registered
characteristics of such Existing Warrants. The Company also acknowledges that the holding period of the Exchange Warrant may be tacked on to the holding period of such Existing Warrants for purposes of Rule 144 of the Securities Act (“Rule
144”). The Company agrees not to take a position contrary to this Section 6. The Company acknowledges and agrees that (i) upon issuance in accordance with the terms of the Exchange Warrant and hereof, the Exchange Shares are
eligible to be resold without restriction pursuant to Rule 144, (ii) the Company is not aware of any event reasonably likely to occur that would reasonably be expected to result in the Exchange Shares becoming ineligible to be resold by the Holder
pursuant to Rule 144 and (iii) in connection with any resale of any Exchange Shares pursuant to Rule 144, the Holder shall solely be required to provide reasonable assurances that 

  
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such Exchange Shares are eligible for resale, assignment or transfer under Rule 144, which shall not include an opinion of Holder’s counsel. The Company shall be responsible for any transfer
agent fees or Depository Trust Company fees or legal fees of the Company’s counsel with respect to the removal of legends, if any, or issuance of Exchange Shares in accordance herewith. 

7.    Listing. The Company shall use reasonable best efforts to promptly secure the listing or designation
for quotation (as applicable) of all of the Exchange Shares upon the Nasdaq Capital Market (the “Principal Market”) (subject to official notice of issuance).    The Company shall pay all fees and expenses in
connection with satisfying its obligations under this Section 7. 
 8.    [Intentionally Omitted] 

9.    Form D and Blue Sky. The Company shall make all filings and reports relating to the Exchange as
required under applicable securities or “Blue Sky” laws of the states of the United States following the date hereof, if any. 

10.    Effective Date. Except as otherwise provided herein, this Agreement shall be deemed effective as of
such date that the Company and the Holder shall have duly executed and delivered this Agreement (the “Effective Date”). 

11.    No Commissions. Neither the Company nor the Holder has paid or given, or will pay or give, to any
person, any commission, fee or other remuneration, directly or indirectly, in connection with the transactions contemplated by this Agreement. 

12.    Termination. Notwithstanding anything contained in this Agreement to the contrary, if the Effective
Date has not occurred and the Company does not deliver the Exchange Warrant to the Holder in accordance with Section 1 hereof, then, at the election of the Holder delivered in writing to the Company at any time after the fifth (5th) Business
Day immediately following the date of this Agreement, this Agreement shall be terminated and be null and void ab initio and the Existing Warrant shall not be cancelled hereunder and shall remain outstanding as if this Agreement never existed. 

13.    Most Favored Nation. 

(a)    The Company hereby represents and warrants as of the date hereof and covenants and agrees from and after the date
hereof that none of the terms offered to any other holder of warrants to purchase Common Stock in the form of the Existing Warrant outstanding as of the date hereof (including, without limitation, any Other Holder) (each, an “Other
Triggering Holder”) with respect to any consent, release, amendment, settlement or waiver relating to any Other Warrant or the terms, conditions and transactions contemplated hereby or by any Other Agreement (each a “Settlement
Document”), is or will be more favorable to such Other Triggering Holder than those of the Holder and this Agreement. If, and whenever on or after the date hereof, the Company enters into a Settlement Document, then (i) the Company
shall provide notice thereof to the Holder immediately following the occurrence thereof and (ii) the terms and conditions of this Agreement shall be, without any further action by the Holder or the Company, automatically amended and modified in
an economically and legally equivalent manner such that the Holder shall receive the benefit of the more favorable terms and/or conditions (as the case may be) set forth in such Settlement Document, provided that upon written notice to the Company
at any time the Holder may elect not to accept the benefit of any such amended or modified term or 

  
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condition, in which event the term or condition contained in this Agreement shall apply to the Holder as it was in effect immediately prior to such amendment or modification as if such amendment
or modification never occurred with respect to the Holder. The provisions of this Section 13 shall apply similarly and equally to each Settlement Document. 

(b)    Holder acknowledges that the Company is negotiating with Other Holders to exchange Existing Warrants for shares of
Common Stock. Holder has reviewed the form the Exchange Agreement for the Other Holders and agrees that such documents do not constitute a more favorable than the terms offered in this Agreement and do not trigger any rights under Section 13(a)
above. 
 14.    Independent Nature of Holder’s Obligations and Rights. The obligations of the
Holder under this Agreement are several and not joint with the obligations of any Other Holder, and the Holder shall not be responsible in any way for the performance of the obligations of any Other Holder under any Other Agreement. Nothing
contained herein or in any Other Agreement, and no action taken by the Holder pursuant hereto, shall be deemed to constitute the Holder and Other Holders as a partnership, an association, a joint venture or any other kind of entity, or create a
presumption that the Holder and Other Holders are in any way acting in concert or as a group with respect to such obligations or the transactions contemplated by this Agreement or any Other Agreement and the Company acknowledges that, to the best of
its knowledge, the Holder and the Other Holders are not acting in concert or as a group with respect to such obligations or the transactions contemplated by this Agreement or any Other Agreement. The Company and the Holder confirm that the Holder
has independently participated in the negotiation of the transactions contemplated hereby with the advice of its own counsel and advisors. The Holder shall be entitled to independently protect and enforce its rights, including, without limitation,
the rights arising out of this Agreement, and it shall not be necessary for any Other Holder to be joined as an additional party in any proceeding for such purpose. 

15.    Miscellaneous. 

(a)    Governing Law; Consent to Jurisdiction. All questions concerning the construction, validity, enforcement and
interpretation of this Agreement shall be governed by the internal laws of the State of New York, without giving effect to any choice of law or conflict of law provision or rule (whether of the State of New York or any other jurisdictions) that
would cause the application of the laws of any jurisdictions other than the State of New York. Each party hereby irrevocably submits to the exclusive jurisdiction of the state and federal courts sitting in The City of New York, Borough of Manhattan,
for the adjudication of any dispute hereunder or in connection herewith or with any transaction contemplated hereby or discussed herein, and hereby irrevocably waives, and agrees not to assert in any suit, action or proceeding, any claim that it is
not personally subject to the jurisdiction of any such court, that such suit, action or proceeding is brought in an inconvenient forum or that the venue of such suit, action or proceeding is improper. Each party hereby irrevocably waives personal
service of process and consents to process being served in any such suit, action or proceeding by mailing a copy thereof to such party at the address for such notices to it under this Agreement and agrees that such service shall constitute good and
sufficient service of process and notice thereof. Nothing contained herein shall be deemed to limit in any way any right to serve process in any manner permitted by law. Nothing contained herein shall be deemed or operate to preclude either party
from bringing suit or taking other legal action against the other party in any other jurisdiction to collect on such party’s obligations to the Holder, to realize on any collateral or any other security for such obligations, or to enforce a
judgment or 

  
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other court ruling in favor of the Holder. THE PARTIES HEREBY IRREVOCABLY WAIVE ANY RIGHT IT MAY HAVE, AND AGREES NOT TO REQUEST, A JURY TRIAL FOR THE ADJUDICATION OF ANY DISPUTE HEREUNDER OR
IN CONNECTION WITH OR ARISING OUT OF THIS AGREEMENT OR ANY TRANSACTION CONTEMPLATED HEREBY. 

(b)    Notices. All notices and other communications provided for or permitted hereunder shall be made in
accordance with Section 8 of the Existing Warrant. 
 (c)    Entire Agreement. This Agreement constitutes
the entire understanding and agreement of the parties with respect to the subject matter hereof and supersedes all prior and/or contemporaneous oral or written proposals or agreements relating thereto all of which are merged herein. This Agreement
may not be amended or any provision hereof waived in whole or in part, except by a written amendment signed by both of the parties. 

(d)    Counterparts. This Agreement may be executed in two or more identical counterparts, all of which shall be
considered one and the same agreement and shall become effective when counterparts have been signed by each party and delivered to the other party; provided that a facsimile signature shall be considered due execution and shall be binding upon the
signatory thereto with the same force and effect as if the signature were an original, not a facsimile signature. 

(e)    Severability. If any provision of this Agreement is prohibited by law or otherwise determined to be invalid
or unenforceable by a court of competent jurisdiction, the provision that would otherwise be prohibited, invalid or unenforceable shall be deemed amended to apply to the broadest extent that it would be valid and enforceable, and the invalidity or
unenforceability of such provision shall not affect the validity of the remaining provisions of this Agreement so long as this Agreement as so modified continues to express, without material change, the original intentions of the parties as to the
subject matter hereof and the prohibited nature, invalidity or unenforceability of the provision(s) in question does not substantially impair the respective expectations or reciprocal obligations of the parties or the practical realization of the
benefits that would otherwise be conferred upon the parties. The parties will endeavor in good faith negotiations to replace the prohibited, invalid or unenforceable provision(s) with a valid provision(s), the effect of which comes as close as
possible to that of the prohibited, invalid or unenforceable provision(s). 
 (f)    Successors and Assigns. This
Agreement shall be binding upon and inure to the benefit of the parties and their respective successors and assigns, including any purchasers of the Existing Warrants. 

(g)    No Third Party Beneficiaries. This Agreement is intended for the benefit of the parties hereto and their
respective permitted successors and assigns, and is not for the benefit of, nor may any provision hereof be enforced by, any other Person. 

(h)    Survival. The representations, warranties and covenants of the Company and the Holder contained herein shall
survive the Closing and delivery of the Exchange Shares. 
 (i)    Further Assurances. Each party shall do and
perform, or cause to be done and performed, all such further acts and things, and shall execute and deliver all such other agreements, 

  
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certificates, instruments and documents, as any other party may reasonably request in order to carry out the intent and accomplish the purposes of this Agreement and the consummation of the
transactions contemplated hereby. 
 (j) No Strict Construction. The language used in this Agreement will be deemed to be the
language chosen by the parties to express their mutual intent, and no rules of strict construction will be applied against any party. 
 [The
remainder of the page is intentionally left blank] 

  
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 IN WITNESS WHEREOF, Holders and the Company have executed this Agreement as of the
date set forth on the first page of this Agreement. 
  

			
	COMPANY:
	
	TYME TECHNOLOGIES, INC.
		
	By:	 	
                     
                                        

		 	Name:
		 	Title:

 [Signature Page to Exchange Agreement] 

 IN WITNESS WHEREOF, Holders and the Company have executed this Agreement as of the
date set forth on the first page of this Agreement. 
  

			
	HOLDER:
	
	[HOLDER NAME]
		
	By:	 	  

		 	Name:
		 	Title:

  
 [Signature Page to
Exchange Agreement]EX-10.3

 Exhibit 10.3 

[Holder] 
 [Address] 

[Address] 
 [Address] 

May     , 2020 
 Dear Sirs:

 This agreement (the “Leak-Out Agreement”) is being delivered to you in
connection with that certain understanding by and between Tyme Technologies, Inc., a Delaware corporation (the “Company”) and the undersigned (“Holder”). 

Reference is hereby made to that certain Exchange Agreement, dated May     , 2020 (the “Exchange
Agreement”), by and among the Company and the Holder, pursuant to which, among other things, the Holder exchanged certain warrants to purchase Common Stock (as defined in the Exchange Agreement) previously issued by the Company to the
Holder into certain Exchange Shares (as defined in the Exchange Agreement) (collectively, the “Restricted Securities”). Capitalized terms not defined herein shall have the meaning as set forth in the Exchange Agreement. 

During the period commencing on the date of issuance of the Restricted Securities (“Execution Date”) and ending on (i)
[                    ]1 or (ii) such date upon which any breach by the Company of any term
of this Leak-Out Agreement or the Exchange Agreement occurs, regardless of whether such breach is subsequently cured (the “Standstill End Date”), the Holder and any Affiliate of the Holder
which (x) had or has knowledge of the transactions contemplated by the Warrant or Exchange Agreement, (y) has or shares discretion relating to such Holder’s investments or trading or information concerning such Holder’s
investments, including in respect of the Restricted Securities, or (z) is controlled by Holder or is subject to such Holder’s review or input concerning such Affiliate’s investments or trading (together, the “Holder’s
Trading Affiliates”) shall not offer, pledge, sell, contract to sell, option, lend or dispose or otherwise transfer, directly or indirectly, (including, without limitation, any sales, swaps or any derivative transactions that would be
equivalent to any sales) any of the Restricted Securities or enter into any new short sales or short positions. During the period immediately following the Standstill End Date through the earlier to occur of (i)
[                    ] 2 or (ii) such date upon which any breach by the Company of any term
of this Leak-Out Agreement or the Exchange Agreement occurs, regardless of whether such breach is subsequently cured (such period, the “Restricted Period”), the Holder and Holder’s
Trading Affiliates shall not offer, pledge, sell, contract to sell, option, lend or dispose or otherwise transfer, directly or indirectly, (including, without limitation, any sales, swaps or any derivative transactions that would be equivalent to
any sales) on any Trading Day during the Restricted Period (any such date, a “Date of Determination”) Restricted Securities, in the aggregate, in an amount representing more than 2.5% of the daily composite trading volume of Common
Stock as reported by Bloomberg, LP on such applicable Date of Determination or enter into new short sales or short 
  

	1 	 Insert 90 calendar days after the date hereof 

	2 	 Insert 180 calendar days after the date hereof 

 
positions. For the avoidance of doubt, it is acknowledged that Holder may currently maintain short positions in the Company’s common stock. None of the foregoing restrictions shall prohibit
such short positions already existing on the date hereof, or the settlement thereof, provided that such settlements using Restricted Securities comply with the volume limitations set forth above. Notwithstanding anything herein to the contrary,
nothing herein shall prohibit the Holder (or any of its Trading Affiliates) from tendering any Restricted Securities or other shares of Common Stock to any Person in a tender offer or other Fundamental Transaction. 

Notwithstanding anything herein to the contrary, on or after the date hereof, the Holder may, directly or indirectly, sell or transfer all, or
any part, of the Restricted Securities to any Person (an “Assignee”) in a transaction which does not need to be reported on the Nasdaq consolidated tape without complying with (or otherwise limited by) the restrictions set forth in
this Leak-Out Agreement; provided, however that as a condition to any such sale or transfer an authorized signatory of the Company and such Assignee duly execute and deliver a
leak-out agreement in the form of this Leak-Out Agreement with respect to such transferred Restricted Securities (an “Assignee Agreement”) and sales of
the Holder and its Affiliates and all Assignees shall be aggregated for all purposes of this Leak-Out Agreement and all Assignee Agreements. 

Any notices, consents, waivers or other communications required or permitted to be given under the terms of this Leak-Out Agreement must be in writing. 
 This Leak-Out Agreement,
together with the Exchange Agreement, constitutes the entire agreement among the parties hereto with respect to the subject matter hereof and supersedes all prior negotiations, letters and understandings relating to the subject matter hereof and are
fully binding on the parties hereto. 
 This Leak-Out Agreement may be executed simultaneously in
any number of counterparts. Each counterpart shall be deemed to be an original, and all such counterparts shall constitute one and the same instrument. This Leak-Out Agreement may be executed and accepted by
facsimile or PDF signature and any such signature shall be of the same force and effect as an original signature. 
 The terms of this Leak-Out Agreement shall be binding upon and shall inure to the benefit of each of the parties hereto and their respective successors and assigns. 

This Leak-Out Agreement may not be amended or modified except in writing signed by each of the parties
hereto. 
 All questions concerning the construction, validity, enforcement and interpretation of this letter agreement shall be governed by
the internal laws of the State of New York, without giving effect to any choice of law or conflict of law provision or rule (whether of the State of New York or any other jurisdictions) that would cause the application of the laws of any
jurisdictions other than the State of New York. Each party hereby irrevocably submits to the exclusive jurisdiction of the state and federal courts sitting in The City of New York, Borough of Manhattan, for the adjudication of any dispute hereunder
or in connection herewith or with any transaction contemplated hereby or discussed herein, and hereby irrevocably waives, and agrees not to assert 

  
 2 

 
in any suit, action or proceeding, any claim that it is not personally subject to the jurisdiction of any such court, that such suit, action or proceeding is brought in an inconvenient forum or
that the venue of such suit, action or proceeding is improper. 
 Each party hereby irrevocably waives personal service of process and
consents to process being served in any such suit, action or proceeding by mailing a copy thereof to such party at the address for such notices to it under this letter agreement and agrees that such service shall constitute good and sufficient
service of process and notice thereof. Nothing contained herein shall be deemed to limit in any way any right to serve process in any manner permitted by law. Nothing contained herein shall be deemed to limit in any way any right to serve process in
any manner permitted by law. Each party hereby irrevocably waives any right it may have, and agrees not to request, a jury trial for the adjudication of any dispute hereunder or in connection with or arising out of this letter agreement or any
transaction contemplated hereby. 
 Each party hereto acknowledges that, in view of the uniqueness of the transactions contemplated by this
letter agreement, the other parties hereto would not have an adequate remedy at law for money damages in the event that this Leak-Out Agreement has not been performed in accordance with its terms, and
therefore agrees that such other parties shall be entitled to specific enforcement of the terms hereof in addition to any other remedy to which it may be entitled, at law or in equity. 

If, and whenever on or after the date hereof, the Company enters into, amends, terminates, waives or modifies a
leak-out agreement (or any other agreement or other document restricting in any manner the sale, directly or indirectly, by any Other Holder or any of its Trading Affiliates of any securities of the Company)
with any Other Holder (or any of its Trading Affiliates), directly or indirectly, of any Other Exchange Shares or Exchange Warrants (each such agreement, an “Other Agreement”) in any manner, the result of which, is more favorable
terms and/or conditions and/or less trading restrictions (as the case may be) on Other Exchange Shares or shares issuable under Exchange Warrants then held by such Other Holder, then as set forth herein, then (i) the Company shall provide
notice thereof to the Holder immediately following the occurrence thereof and (ii) the terms and conditions of this Agreement shall be, without any further action by the Holder or the Company, automatically amended and modified in an
economically and legally equivalent manner such that the Holder shall receive the benefit of the more favorable terms and/or conditions and/or less restrictions (as the case may be) set forth in such Other Agreement, provided that upon written
notice to the Company at any time the Holder may elect not to accept the benefit of any such amended or modified term or condition, in which event the term or condition contained in this Agreement shall apply to the Holder as it was in effect
immediately prior to such amendment or modification as if such amendment or modification never occurred with respect to the Investor. The provisions of this paragraph shall apply similarly and equally to each such Other Agreement. Holder
acknowledges that the Company is negotiating with one or more Other Holders to exchange Existing Warrants for Exchange Warrants. Holder has reviewed the form of the Other Agreement for such Holders and agrees that such Other Agreement does not
contain more favorable terms and/or conditions and/or less trading restrictions than this Agreement and does not trigger any rights hereunder. 

The obligations of Holder under this Agreement are several and not joint with the obligations of any Other Holder under any other agreement,
and Holder shall not be responsible 

  
 3 

 
in any way for the performance of the obligations of any Other Holder under any such other agreement. Nothing contained herein or in this Agreement, and no action taken by Holder pursuant hereto,
shall be deemed to constitute Holder and Other Holders as a partnership, an association, a joint venture or any other kind of entity, or create a presumption that Holder and the Other Holders are in any way acting in concert or as a group with
respect to such obligations or the transactions contemplated by this Agreement and the Company acknowledges that Holder and the Other Holders are not acting in concert or as a group with respect to such obligations or the transactions contemplated
by this Agreement or any other Agreement. The Company and Holder confirms that Holder has independently participated in the negotiation of the transactions contemplated hereby with the advice of its own counsel and advisors. Holder shall be entitled
to independently protect and enforce its rights, including, without limitation, the rights arising out of this Agreement, and it shall not be necessary for any Other Holder to be joined as an additional party in any proceeding for such purpose. 

[SIGNATURE PAGE TO LEAK-OUT] 

  
 4 

			
	Agreed to and Acknowledged:
	
	TYME TECHNOLOGIES, INC.
		
	By:	 	
                     
                    

		 	Name:
		 	Title:
	
	[HOLDER]
		
	By:	 	
                     
                    

		 	Name:
		 	Title:

  
 [Signature Page to
Leak-Out Agreement]

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