Document:

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                                                                     EXHIBIT 4.7

                          REGISTRATION RIGHTS AGREEMENT

     This Registration Rights Agreement (the "Agreement") is made this 23rd day
of April, 1999, by and between Genomic Solutions, Inc., a Delaware corporation,
4355 Varsity Drive, Suite E, Ann Arbor, Michigan 48108 ("Company") and White
Pines Limited Partnership I, a Michigan limited partnership, 2401 Plymouth Road,
Suite B, Ann Arbor, Michigan 48105 (hereinafter referred to as "WPLP") Pacific
Capital, L.P., a Delaware limited partnership, 2401 Plymouth Road, Suite B, Ann
Arbor, Michigan 48105 (hereinafter referred to as "Pacific"), Chase Venture
Capital Associates, L.P., a California limited partnership, 380 Madison Avenue,
12th Floor, New York, New York 10017 (hereinafter referred to as "Chase"),
American Healthcare Fund II, a Delaware limited partnership, 4430 Arapahoe
Avenue, Suite 220, Boulder, Colorado 80303 (hereinafter referred to as
"American"), Ian R. N. Bund Smith Barney Prototype PS Plan Account
#206-08291-12445, P.O. Box 2022, Bloomfield Hills, Michigan 48303 (hereinafter
referred to as "Bund"), Yocum Consulting Associates, Inc., an Ohio corporation,
4622 Wyndwood Drive, Toledo, Ohio 43623 (hereinafter referred to as "Yocum"),
Volunteer Healthcare Associates, L.L.C., a Tennessee limited liability company,
6 Cadillac Drive, Suite 310, Brentwood, Tennessee 37027 (hereinafter referred to
as "Volunteer"), McDonald Investments Inc. Custodian FBO S. Sterling McMillan
III IRA Rollover Account #85362191, 2550 Som Center Road, Suite 300, Willoughby
Hills, Ohio 44094 (hereinafter referred to as "McMillan"), J. Matthew Mackowski,
275 Post Street, Suite 600, San Francisco, California 94108 (hereinafter
referred to as "Mackowski-CA") , Robert G. Shepler, 275 Post Street, Suite 600,
San Francisco, California 94108 (hereinafter referred to as "Shepler"), John J.
Mackowski, 1506 Birkdale Lane, Ponte Verde Beach, Florida 32082 (hereinafter
referred to as "Mackowski-FL"), Grove Investment Partners, an Illinois
partnership, 336 Essex Road, Kenilworth, Illinois 60043 (hereinafter referred to
as "Grove") Ronald G. Kalish Living Trust u/a/d September 9, 1997, 445 Grand Bay
Drive, #1009, Key Biscayne, Florida 33149 (hereinafter referred to as "Kalish"),
Lois F. Marler, 48951 Fox Drive South, Plymouth, Michigan 48170 (hereinafter
referred to as "Marler"), McDonald Investments Inc. Custodian FBO Daniel J.
Boyle IRA Rollover Account #85314893, 2550 Som Center Road, Suite 300,
Willoughby Hills, Ohio 44094 (hereinafter referred to as "Boyle"), National
City Bank of MI/IL, Custodian FBO Herbert S. Amster IRA Rollover Account dated
June 12, 1991 Account #MI-1491-00-4, 101 National City Bank, 101 S. Main Street,
Ann Arbor, Michigan 48104 (hereinafter referred to as "Amster"), Kantner and
Associates Profit Sharing Plan u/a/d January 1, 1991, 555 East William Street,
Ann Arbor, Michigan 48104 (hereinafter referred to as "Kantner") and Michael G.
Williams, 18000 Cavanaugh Lake Road, Chelsea, Michigan 48118 (hereinafter
referred to as "Williams") (WPLP, Pacific, Chase, American, Bund, Yocum,
Volunteer, McMillan, Mackowski-CA, Shepler, Mackowski-FL, Grove, Kalish, Marler,
Boyle, Amster, Kantner and Williams hereinafter referred to collectively as
"Purchasers").

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     1. Certain Definitions. As used in this Agreement, the following terms
shall have the following respective meanings:

        (a) "Commission" means the Securities and Exchange Commission, or any
other Federal agency at the time administering the Securities Act.

        (b) "Equity Security" shall have the meaning ascribed to such term in
the rules and regulations of the Commission issued under the Securities Act.

        (c) "Exchange Act" means the Securities Exchange Act of 1934, as
amended, or any similar Federal statute, and the rules and regulations of the
Commission issued under such Act, as they each may, from time to time, be in
effect.

        (d) "Initial Public Offering" means the effective date of a Registration
Statement covering the Company's first underwritten public offering of Common
Stock, resulting in gross proceeds to the Company of at least $5,000,000.

        (e) "Loan Agreement" shall mean the Business Loan Agreement of even date
herewith between Company and Purchasers.

        (f) "Registration Statement" means a registration statement filed by the
Company with the Commission for a public offering and sale of securities of the
Company (other than a registration statement on Form S-8 or Form S-4, or their
successors, or any other similar form, or any registration statement covering
only securities proposed to be issued in exchange for securities or assets of
another corporation).

        (g) "Registration Expenses" means the expenses described in Section 5.

        (h) "Registrable Shares" means (i) the shares of Common Stock issued or
issuable upon exercise of the Warrants, (ii) any shares of Common Stock, or
shares of Common Stock issued or issuable upon exercise or conversion of any
equity security, acquired by the Purchasers pursuant to any preemptive right it
has under the Shareholders Agreement, and (iii) any other shares of Common Stock
issued in respect of the shares of Common Stock described in subparagraphs (i)
and (ii) above (because of stock splits, stock dividends, reclassifications,
recapitalizations, or similar events), provided, however, that shares of Common
Stock which are Registrable Shares shall cease to be Registrable Shares upon any
sale pursuant to a Registration Statement, Section 4(l) of the Securities Act or
Rule 144 under the Securities Act. Wherever reference is made in this Agreement
to a request or consent of holders of a certain percentage of Registrable
Shares, the determination of such percentage shall include shares of Common
Stock issuable upon exercise of the Warrants even if such exercise has not yet
occurred.
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        (i) "Securities Act" means the Securities Act of 1933, as amended, or
any similar Federal statute, and the rules and regulations of the Commission
issued under such Act, as they each may, from time to time, be in effect.

        (j) "Shareholders Agreement" means the shareholder agreement dated
December 24, 1997 among Parent and various shareholders of Parent, as amended
May 27, 1998, and as further amended as of the date hereof.

        (k) "Shareholders" means the Purchasers and any persons or entities to
whom the rights granted under this Agreement are transferred by the Purchasers,
and their successors or assigns.

        (1) "Warrants" means the warrants initially issued to Purchasers on the
date hereof pursuant to the terms and provisions of the Loan Agreement and any
and all additional Warrants hereafter issued pursuant to the terms and
provisions of the Loan Agreement or such warrants.

     2. Required Registrations.

        (a) At any time after the end of the nine-month period following the
Initial Public Offering pursuant to a Registration Statement, a Shareholder or
Shareholders holding in the aggregate at least thirty percent of the Registrable
Shares may request, in writing, that the Company effect the registration on Form
S-1, or if available, Form S-3 (or any successor form) of Registrable Shares
owned by such Shareholder or Shareholders having an aggregate offering price of
at least $1,000,000 (based on the then current market price or fair value). If
the holders initiating the registration intend to distribute the Registrable
Shares by means of an underwriting, they shall so advise the Company in their
request of such intention and of their selection of an underwriter (which
selection shall be subject to the consent of the Company, which consent shall
not be unreasonably withheld). In the event such registration is underwritten,
the right of other Shareholders to participate shall be conditioned on such
Shareholders' participation in such underwriting. Upon receipt of any such
request, the Company shall promptly give written notice of such proposed
registration to all Shareholders. Such Shareholders shall have the right, by
giving written notice to the Company within 30 days after the Company provides
its notice, to elect to have included in such registration such of their
Registrable Shares as they may request in such notice of election. If in the
opinion of the managing underwriter the registration of all the Registrable
Shares which the Shareholders have requested to be included would materially and
adversely affect such public offering, then only that number of Registrable
Shares which the managing underwriter believes may be sold without causing such
material adverse effect shall be included in the underwriting. The Shareholders
of Registrable Shares who

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have requested registration shall participate in the underwriting pro rata based
upon the number of shares of Common Stock of the Company that such Shareholders
have requested to be so included. The Company shall, as expeditiously as
possible, use its best efforts to effect the registration of all Registrable
Shares which the Company has been requested to so register. If the managing
underwriter or underwriters have not limited the number of shares to be
underwritten, the Company may include securities for its own account or the
account of others in such registration if the managing underwriter or
underwriters so agree and if the number of Registrable Shares which would
otherwise have been included in such registration and underwriting will not
thereby be decreased.

        (b) At any time after the Company becomes eligible to file a
Registration Statement on Form S-3 (or any successor form relating to secondary
offerings), a Shareholder or Shareholders holding in the aggregate at least
thirty percent of the Registrable Shares may request the Company, in writing, to
effect the registration on Form S-3 (or such successor form), of Registrable
Shares having an aggregate offering price of at least $500,000 (based on the
current public market price). Upon receipt of any such request, the Company
shall promptly give written notice of such proposed registration to all
Shareholders. Such Shareholders shall have the right, by giving written notice
to the Company within 30 days after the Company provides its notice, to elect to
have included in such registration such of their Registrable Shares as such
Shareholders may request in such notice of election. Thereupon, the Company
shall, as expeditiously as possible, use its best efforts to effect the
registration of all Registrable Shares which the Company has been requested to
register.

        (c) The Company shall not be required to effect more than one
registration pursuant to Section 2(a) above, or more than one registration
pursuant to Section 2(b) above.

        (d) If at the time of any request to register Registrable Shares
pursuant to this Agreement, the Company is engaged or has bona fide plans to
engage, within 30 days of the time of the request, in a registered public
offering as to which the Shareholders may include Registrable Shares pursuant to
Section 3 or is engaged in any other activity which, in the good faith
determination of the Board, would be adversely affected by the requested
registration to the material detriment of the Company, then the Company may at
its option direct that such request be delayed for a period not in excess of
three months from the effective date of such offering or the date of
commencement of such other material activity, as the case may be.

     3. Incidental Registration.

        (a) Whenever the Company proposes at any time to file a Registration
Statement that contemplates the sale of Common

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Stock or other Equity Security and is on a form which would allow registration
of the Registrable Shares, it will, prior to such filing, give written notice to
all Shareholders of its intention to do so and, upon the written request of the
Shareholders given within 10 days after the Company provides such notice, the
Company shall use its best efforts to cause all Registrable Shares which the
Company has been requested by such Shareholders to register to be registered
under the Securities Act to the extent necessary to permit their sale or other
disposition in accordance with the intended methods of distribution specified in
the request of the Shareholders; provided, however, that the Company shall have
the right to postpone or withdraw any registration proposed pursuant to this
Section 3(a) without obligation to any Shareholder.

        (b) In connection with any offering under Section 3(a) involving an
underwriting, the Company shall not be required to include any Registrable
Shares in such underwriting unless the holders thereof accept the terms of the
underwriting as agreed upon between the Company and the underwriters selected by
it, and then only in such quantity as will not, in the opinion of the
underwriters, jeopardize the success of the offering by the Company. If in the
opinion of the managing underwriter the registration of all, or part of, the
Registrable Shares which the holders have requested to be included and
securities requested to be included by the parties to the Shareholders Agreement
would materially and adversely affect such public offering, then the Company
shall be required to include in the underwriting only that number of Registrable
Shares and securities owned by the parties to the Shareholders Agreement which
the managing underwriter believes may be sold without causing such material
adverse effect. If the number of Registrable Shares and other securities to be
included in the underwriting in accordance with the foregoing is less than the
total number of shares which the holders of Registrable Shares and other
securities have requested to be included, then the holders of Registrable Shares
who have requested registration shall participate in the underwriting pro rata
based upon the number of shares of Common Stock of the Company that the holders
of the Registrable Shares and the parties to the Shareholders Agreement have
requested to be so included, provided however that the holders of Registrable
Shares shall be entitled to include shares in an underwriting in connection with
a registration effected by the Company pursuant to Section 2.3 or 2.10 of the
Shareholders Agreement only to such extent as the inclusion of such Registrable
Shares will not reduce the amount of securities which are included in such
underwriting owned by the parties to the Shareholders Agreement entitled to
exercise rights under Section 2.3 or 2.10.

     4. Registration Procedures. If and whenever the Company is required by the
provisions of this Agreement to use its best efforts to effect the registration
of any of the Registrable Shares under the Securities Act, the Company shall:

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        (a) File with the Commission a Registration Statement with respect to
such Registrable Shares and use its best efforts to cause that Registration
Statement to become and remain effective;

        (b) As expeditiously as possible prepare and file with the Commission
any amendments and supplements to the Registration Statement and the prospectus
included in the Registration Statement as may be necessary to keep the
Registration Statement effective for a period of not less than 90 days from the
effective date;

        (c) As expeditiously as possible furnish to each selling Shareholder
such reasonable number of copies of the prospectus, including a preliminary
prospectus, in conformity with the requirements of the Securities Act, and such
other documents as the selling Shareholder may reasonably request in order to
facilitate the public sale or other disposition of the Registrable Shares owned
by the selling Shareholder;

        (d) As expeditiously as possible use its best efforts to register or
qualify the Registrable Shares covered by the Registration Statement under the
securities or blue sky laws of such states as the selling Shareholders shall
reasonably request, and do any and all other acts and things that may be
necessary or desirable to enable the selling Shareholders to consummate the
public sale or other disposition within such states of the Registrable Shares
owned by the selling Shareholders; provided, however, that the Company shall not
be required in connection with this paragraph (d) to qualify as a foreign
corporation in any jurisdiction, execute a general consent to service of process
in any jurisdiction, or subject itself to taxation in any jurisdiction; and

        (e) Use its best efforts to cause the Registrable Shares to be listed on
the principal securities exchange on which similar securities of the Company are
then listed, if any, if the listing of such shares is then permitted under the
rules of such exchange.

        (f) If the Company has delivered preliminary or final prospectuses to
the selling Shareholders and after having done so the prospectus is amended to
comply with the requirements of the Securities Act, the Company shall promptly
notify the selling Shareholders and, if requested, the selling Shareholders
shall immediately cease making offers of Registrable Shares and return all
prospectuses to the Company. The Company shall promptly provide the selling
Shareholders with revised prospectuses and, following receipt of the revised
prospectuses and compliance with any related requirements of the Securities Act
and any applicable state securities or blue sky laws, the selling Shareholders
shall be free to resume making offers of the Registrable Shares.

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     5. Allocation of Expenses. The Company will pay all Registration Expenses
of all registrations under this Agreement; provided, however, that if a
registration is withdrawn at the request of the Shareholders requesting such
registration (other than as a result of information concerning the business or
financial condition of the Company which is made known to the Shareholders after
the date on which such registration was requested) and if the requesting
Shareholders elect not to have such registration counted as a registration
requested under Section 2(a), the requesting Shareholders shall pay the
Registration Expenses of such registration pro rata in accordance with the
number of their Registrable Shares included in such registration. For purposes
of this Section 5, the term "Registration Expenses" shall mean all expenses
incurred by the Company in complying with this Agreement, including, without
limitation, all registration and filing fees, exchange listing fees, printing
expenses, fees of accountants for the Company, fees and disbursements of counsel
for the Company and the fees and expenses (not in excess $10,000) of one counsel
selected by the selling Shareholders to represent the selling Shareholders,
state securities or blue sky fees and expenses, and the expense of any special
audits incident to or required by any such registration, but excluding
underwriting discounts, selling commissions or any other brokerage or
underwriting fees and expenses and the fees and expenses of the selling
Shareholders' own counsel (other than the one counsel selected to represent all
selling Shareholders).

     6. Indemnification.

        (a) In the event of any registration of any of the Registrable Shares
under the Securities Act pursuant to this Agreement, the Company will indemnify
and hold harmless the seller of such Registrable Shares, each underwriter of
such Registrable Shares, and each other person, if any, who controls such seller
or underwriter within the meaning of the Securities Act or the Exchange Act
against any losses, claims, damages or liabilities, joint or several, to which
such seller, underwriter or controlling person may become subject under the
Securities Act, the Exchange Act, state securities or blue sky laws or
otherwise, insofar as such losses, claims, damages or liabilities (or actions in
respect thereof) arise out of or are based upon any untrue statement or alleged
untrue statement of any material fact contained in any Registration Statement
under which such Registrable Shares were registered under the Securities Act,
any preliminary prospectus or final prospectus contained in the Registration
Statement, or any amendment or supplement to such Registration Statement, or
arise out of or are based upon the omission or alleged omission to state a
material fact required to be stated therein or necessary to make the statements
therein not misleading; and, subject to Section 6(c) below, the Company will
reimburse such seller, underwriter and each such controlling person for any
legal or any other expenses reasonably incurred by such seller, underwriter or
controlling person in connection with

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investigating or defending any such loss, claim, damage, liability or action;
provided, however, that the Company will be liable in any such case to the
extent that any such loss, claim, damage or liability arises out of or is based
upon (i) any untrue statement or omission made in such Registration Statement,
preliminary prospectus or prospectus, or any such amendment or supplement, in
reliance upon and in conformity with information furnished to the Company, in
writing, by or on behalf of such seller, underwriter or controlling person
specifically for use in the preparation thereof or, (ii) the failure of such
seller to deliver copies of the prospectus in the manner required by the
Securities Act.

        (b) In the event of any registration of any of the Registrable Shares
under the Securities Act pursuant to this Agreement, each seller of Registrable
Shares, severally (and not jointly or jointly and severally), will indemnify and
hold harmless the Company, each of its directors and officers and each
underwriter, if any, and each person, if any, who controls the Company or any
such underwriter within the meaning of the Securities Act or the Exchange Act,
against any losses, claims, damages or liabilities, joint or several, to which
the Company, such directors and officers, underwriter or controlling person may
become subject under the Securities Act, Exchange Act, state securities or blue
sky laws or otherwise, insofar as such losses, claims, damages or liabilities
(or actions in respect thereof) arise out of or are based upon any untrue
statement of a material fact contained in any Registration Statement under which
such Registrable Shares were registered under the Securities Act, any
preliminary prospectus or final prospectus contained in the Registration
Statement, or any amendment or supplement to the Registration Statement, or
arise out of or are based upon any omission to state a material fact required to
be stated therein or necessary to make the statements therein not misleading, if
the statement or omission was made in reliance upon and in conformity with
information furnished in writing to the Company by or on behalf of such seller,
specifically for use in connection with the preparation of such Registration
Statement, prospectus, amendment or supplement.

        (c) Each party entitled to indemnification under this Section 6 (the
"Indemnified Party") shall give notice to the party required to provide
indemnification (the "Indemnifying Party") within a reasonable period of time
after such Indemnified Party has actual knowledge of any claim as to which
indemnity may be sought, and shall permit the Indemnifying Party to assume the
defense of any such claim or any litigation resulting therefrom; provided,
however, that counsel for the Indemnifying Party, who shall conduct the defense
of such claim or litigation, shall be approved by the Indemnified Party (whose
approval shall not be withheld unreasonably). The Indemnified Party may
participate in such defense at such party's expense; provided, however, that the
Indemnifying Party shall pay such expense if representation of such Indemnified
Party by the counsel retained by the

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Indemnifying Party would be inappropriate due to actual or potential differing
interests between the Indemnified Party and any other party represented by such
counsel in such proceeding. No Indemnifying Party in the defense of any such
claim or litigation shall, except with the prior written consent of each
Indemnified Party, consent to entry of any judgment or enter into any settlement
which does not include as an unconditional term thereof the giving by the
claimant or plaintiff to such Indemnified Party of a release from all liability
in respect of such claim or litigation, and no Indemnified Party shall consent
to entry of any judgment or settle such claim or litigation without the prior
written consent of the Indemnifying Party.

     7. Indemnification with Respect to Underwritten Offering. In the event that
Registrable Shares are sold pursuant to a Registration Statement in an
underwritten offering pursuant to Section 2(a), the Company agrees to enter into
an underwriting agreement containing customary representations and warranties
with respect to the business and operations of an issuer of the securities being
registered and customary covenants and agreements to be performed by such
issuer, including without limitation customary provisions with respect to
indemnification by the Company of the underwriters of such offering.

     8. Information by Holder. Each holder of Registrable Shares included in any
registration shall furnish to the Company such information regarding such holder
and the distribution proposed by such holder as the Company may request in
writing if it is required in connection with any registration, qualification or
compliance referred to in this Agreement.

     9. "Lock-Up" Agreement. Each Shareholder, if requested by the Company and
an underwriter of Common Stock or other securities of the Company, shall agree
not to sell or otherwise transfer or dispose of any Registrable Shares or other
securities of the Company held by such Shareholder for a specific period of time
(not to exceed 180 days) following the effective date of a Registration
Statement; provided, however, that:

        (a) Such agreement shall only apply to the first such Registration
Statement covering Common Stock to be sold on the Shareholder's behalf to the
public in an underwritten offering;

        (b) All stockholders of Company owning more than one percent of the
total number of shares of Common Stock outstanding (including shares of Common
Stock issuable pursuant to the terms of any Equity Security of Company in
determining both the number of shares of Common Stock owned by any stockholder
and the total number of shares of Common Stock outstanding) and all officers and
directors of the Company enter into similar agreements; and

        (c) Such agreement shall not apply to any Registrable Shares (or other
Equity Security of the Company) held by such Shareholder if they are included in
the Registration Statement.

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     Such agreement shall be in writing in a form satisfactory to the Company
and such underwriter. The Company may impose stop transfer instructions with
respect to the Registrable Shares or other securities subject to the foregoing
restriction until the end of the lock-up period.

     10. Limitations on Other Registration Rights. The Company shall not,
without the prior written consent of Shareholders holding at least two-thirds of
all Registrable Shares, enter into any agreement (other than this Agreement)
with any holder or prospective holder of any securities of the Company which
would allow such holder or prospective holder to demand that his, her or its
securities be included in any registration filed under Section 2 to the extent
that the inclusion of such securities would reduce the amount of Registrable
Shares of the Shareholders included in such registration.

     11. Rule 144 Requirements. After the earliest of (i) the closing of the
sale of securities of the Company pursuant to a Registration Statement, (ii) the
registration by the Company of a class of securities under Section 12 of the
Exchange Act, or (iii) the issuance by the Company of an offering circular
pursuant to Regulation A under the Securities Act, the Company agrees to:

        (a) Make and keep public information available, as those terms are
understood and defined in Rule 144 under the Securities Act;

        (b) Use its best efforts to file with the Commission in a timely manner
all reports and other documents required of the Company under the Securities Act
and the Exchange Act (at any time after it has become subject to such reporting
requirements); and

        (c) Furnish to any holder of Registrable Shares upon request a written
statement by the Company as to its compliance with the reporting requirements of
said Rule 144 (at any time after 90 days following the closing of the first sale
of securities by the Company pursuant to a Registration Statement), and of the
Securities Act and the Exchange Act (at any time after it has become subject to
such reporting requirements), a copy of the most recent annual or quarterly
reports of the Company, and such other reports and documents of the Company as
such holder may reasonably request to avail itself of any similar rule or
regulation of the Commission allowing it to sell any such securities without
registration.

     12. Notices. Any and all notices provided for in this Agreement shall be
given in writing by registered or certified mail, return receipt requested and
shall be deemed to have been given when mailed, and shall be addressed as
follows:

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As to Purchasers:                             As to Company:

White Pines Limited Partnership I             Genomic Solutions, Inc.
2401 Plymouth Road, Suite B                   4355 Varsity Drive, Suite E
Ann Arbor, MI 48105                           Ann Arbor, MI 48108

Pacific Capital, L.P.
2401 Plymouth Road, Suite B
Ann Arbor, MI 48105

White Pines Management, L.L.C.
2401 Plymouth Road, Suite B
Ann Arbor, MI 48105

Chase Venture Capital Associates, L.P.
380 Madison Avenue, 12th Floor
New York, NY 10017

American Healthcare Fund II
4430 Arapahoe Avenue, Suite 220
Boulder, CO 80303

J. Matthew Mackowski
275 Post Street, Suite 600
San Francisco, CA 94108

Robert G. Shepler
275 Post Street, Suite 600
San Francisco, CA 94108

John J. Mackowski
1506 Birkdale Lane
Ponte Verde Beach, FL 32082

Grove Investment Partners
336 Essex Road
Kenilworth, IL 60043

and with a copy to:

Mr. Perry M. Kantner
Kantner and Associates
555 East William Street
Ann Arbor, MI 48104

     13. Entire Agreement. This Agreement together with the Loan Agreement
contain the entire agreement and understanding between the parties with respect
to the subject matter hereof and supersedes all prior agreements, understandings
and representations. No addition or modification to this Agreement is valid
unless made in writing and signed by the parties hereto.

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     14. Waiver of Jury Trial. To the fullest extent permitted by law, and as
separately bargained-for consideration to Purchasers, the Company hereby waives
any right to trial by jury in any action, suit, proceeding or counterclaim of
any kind arising out of or relating to this agreement or the Purchasers' conduct
in respect thereof.

     15. Controlling Law; Jurisdiction. This Agreement shall be construed,
interpreted and enforced in accordance with the laws of the State of Michigan.
Company expressly submits to the jurisdiction and venue in the Federal or state
courts of the State of Michigan by process served by mail on Company at the
address set forth above.

     16. Construction and Interpretation. Should any provision of this Agreement
require judicial interpretation, the parties hereto agree that the court
interpreting or construing the same shall not apply a presumption that the terms
hereof shall be more strictly construed against one party by reason of the rule
of construction that a document is to be more strictly construed against the
party that itself or through its agent prepared the same, it being agreed that
the Company, Purchasers and their respective agents have participated in the
preparation hereof.

     IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of
the day and year first above written.

WHITE PINES LIMITED PARTNERSHIP I GENOMIC SOLUTIONS, INC.
by:  White Pines G.P., L.L.C.,
     its general partner

By: /s/ Frederick L. Yocum             By: /s/ Jeffrey S. Williams
   ----------------------------------     --------------------------------------
   Frederick L. Yocum, Chairman        Jeffrey S. Williams, President
                                                          "Company"

PACIFIC CAPITAL, L.P.
By:  Pacific Capital Corporation,
     its general partner

By: /s/ Frederick L. Yocum
   -----------------------------
   Frederick L. Yocum, Vice-Chairman

IAN R. N. BUND SMITH BARNEY
   PROTOTYPE PS PLAN ACCOUNT
   #206-08291-12445
YOCUM CONSULTING ASSOCIATES, INC.
VOLUNTEER HEALTHCARE ASSOCIATES, L.L.C
MCDONALD INVESTMENTS INC. CUSTODIAN
   FBO S. STERLING MCMILLAN III IRA
   ROLLOVER ACCOUNT #85362191

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RONALD G. KALISH LIVING TRUST U/A/D
   SEPTEMBER 9, 1997
LOIS F. MARLER
MCDONALD INVESTMENTS INC. CUSTODIAN
   FBO DANIEL J. BOYLE IRA
   ROLLOVER ACCOUNT #85314893
NATIONAL CITY BANK OF MI/IL CUSTODIAN
   FBO HERBERT S. AMSTER IRA
   ROLLOVER ACCOUNT DATED JUNE 12, 1991
   #MI-1491-00-4
KANTNER AND ASSOCIATES PROFIT SHARING
   PLAN U/A/D JANUARY 1, 1991
MICHAEL G. WILLIAMS
By:  White Pines Management, L.L.C.,
     a Michigan limited liability
     company, attorney-in-fact

By: /s/ Frederick L. Yocum
   ----------------------------
   Frederick L. Yocum, Chairman

CHASE VENTURE CAPITAL ASSOCIATES, L.P.

By: /s/ Damion Wicker
   ----------------------------
AMERICAN HEALTHCARE FUND II

By: /s/ Dan Mitchell
   ----------------------------

/s/ J. Matthew Mackowski
-------------------------------
J. MATTHEW MACKOWSKI

/s/ Robert G. Shepler
-------------------------------
ROBERT G. SHEPLER

/s/ John J. Mackowski
-------------------------------
JOHN J. MACKOWSKI

GROVE INVESTMENT PARTNERS

By: /s/ John Kerr
   ----------------------------

                   "Purchasers"

                                       13
<PAGE>   14
                     AMENDMENT NO. 1 TO REGISTRATION RIGHTS

     THIS AMENDMENT NO. 1 TO REGISTRATION RIGHTS AGREEMENT (the "Amendment") is
made this 28th day of October 1999 by and between Genomic Solutions, Inc., a
Delaware corporation, 4355 Varsity Drive, Suite E, Ann Arbor, Michigan 48108
("Company") and White Pines Limited Partnership I, Pacific Capital L.P., Chase
Venture Capital Associates, L.P., American Healthcare Fund II, Ian R. N. Bund
Smith Barney Prototype PS Plan Account #206-08291-12445, Yocum Consulting
Associates, Inc., Volunteer Healthcare Associates, L.L.C., McDonald Investments
Inc. Custodian FBO S. Sterling McMillan III IRA Rollover Account #85362191, J.
Matthew Mackowski, Robert G. Shepler, John J. Mackowski, Grove Investment
Partners, Ronald G. Kalish Living Trust u/a/d September 9, 1997, Lois F. Marler,
McDonald Investments Inc. Custodian FBO Daniel J. Boyle IRA Rollover Account
#85314893, National City Bank of MI/IL, Custodian FBO Herbert S. Amster IRA
Rollover Account dated June 12, 1991 Account #MI-1491-00-4, Kantner and
Associates Profit Sharing Plan u/a/d January 1, 1991 and Michael G. Williams
(hereinafter collectively referred to as the "April Lenders"), and White Pines
Limited Partnership I, Pacific Capital L.P., Chase Venture Capital Associates,
L.P., American Healthcare Fund II, Ian R. N. Bund, Yocum Consulting Associates,
Inc., Volunteer Healthcare Associates, L.L.C., J. Matthew Mackowski, Robert G.
Shepler, John J. Mackowski, Grove Investment Partners, Ronald G. Kalish Living
Trust u/a/d September 9, 1997, McDonald Investments Inc. Custodian FBO Daniel J.
Boyle IRA Rollover Account #85314893, Kantner and Associates Profit Sharing Plan
u/a/d January 1, 1991, Michael G. Williams, Lawrence J. Kent, Jeffrey S.
Williams, Kevin A. Auton, Andrew A. Jakimcius, Michael P. Kurek and Steven J.
Richvalsky (hereinafter collectively referred to as the "October Lenders").

                                    RECITALS

     1. Company and the April Lenders entered into a certain Registration Rights
Agreement dated April 23, 1999 (hereinafter referred to as the "Agreement").

     2. Company and the October Lenders are entering into the October Loan
Agreement (as hereinafter defined) pursuant to which Warrants to purchase shares
of common stock of Company are being issued to the October Lenders.

     3. The October Lenders require that the shares of common stock issuable
upon exercise of the Warrants issued pursuant to the October Loan Agreement
constitute "Registrable Shares" for purposes of the Agreement, and Company and
the April Lenders are willing to amend the Agreement for such purposes.

     NOW THEREFORE, in consideration of the foregoing and the original execution
of the Agreement, the parties hereto agree that the Agreement is hereby amended
as follows:

                                       1

<PAGE>   15

     1.   Section 1(e) is hereby amended to read its entirety as follows:

          (e) "April Loan Agreement" shall mean the Business Loan Agreement
          dated April 23, 1999 between Company, Genomic Solutions, Ltd., Genomic
          Solutions, K.K. and the April Lenders.

     2.   Section 1(j) is hereby amended to read in its entirety as follows:

          (j) "Shareholders Agreement" means the shareholder agreement dated
          December 24, 1997 among Company and various shareholders of Company,
          as amended May 27, 1998, and as further amended on April 23, 1999 and
          on the date hereof whereby Purchasers were added as parties thereto as
          to certain provisions.

     3.   Section 1(l) is hereby amended to read in its entirety as follows:

          (1) "Warrants" means (i) the warrants initially issued to the April
          Lenders on April 23, 1999 pursuant to the terms and provisions of the
          April Loan Agreement, (ii) the warrants initially issued to the
          October Lenders on October 28, 1999 pursuant to the terms and
          provisions of the October Loan Agreement, and (iii) any and all
          additional warrants issued after April 23, 1999 pursuant to the terms
          and provisions of the April Loan Agreement, the October Loan Agreement
          or such warrants.

     4.   The following is added as an additional Section 1(m):

          (m) "October Loan Agreement" shall mean the Business Loan Agreement
          dated October 28, 1999 between Company, Genomic Solutions, Ltd.,
          Genomic Solutions, K.K. and the October Lenders.

     5.   The following is added as an additional Section 1(n):

          (n) "Purchasers" means the April Lenders and the October Lenders.

                                       2

<PAGE>   16

     6.   The following names and addresses are hereby added to Section 12:

          Lawrence J. Kent
          404 E. Lancaster Ave.
          Wayne, PA 19087

          Jeffrey S. Williams
          7049 Suncrest Drive
          Saline, MI 48176

          Kevin A. Auton
          42 Croftfield Road
          Godmanchester
          Huntingdon, Cambridgeshire
          PE18 8ED

          Andrew A. Jakimcius
          1096 Heritage Drive
          Saline, MI 48176

          Michael P. Kurek
          2720 Holyoke Lane
          Ann Arbor, MI 48103

          Steven J. Richvalsky
          12215 Deer Creek Drive
          Plymouth, MI 48170

     7.   Except as expressly set forth herein, the Agreement shall be
unaffected by this Amendment and remains in full force and effect.

     IN WITNESS WHEREOF, the parties hereto have executed this Amendment as of
the day and year first above written.

                                        GENOMIC SOLUTIONS, INC.

                                        by /s/ Jeffrey S. Williams
                                           ------------------------------
                                           Jeffrey S. Williams, President

                                       3

<PAGE>   17
                                                                     PAGE 1 OF 2

                                 APRIL LENDERS

WHITE PINES LIMITED PARTNERSHIP I
By:  White Pines G.P., L.L.C.,
     its general partner

By:  /s/ Frederick L. Yocum
     ------------------------------
     Frederick L. Yocum, Chairman

PACIFIC CAPITAL, L.P.

By:  WP Pacific G.P., L.L.C.,
     a general partner

By: /s/ Frederick L. Yocum
    ------------------------------
    Frederick L. Yocum, Chairman

IAN R. N. BUND SMITH BARNEY
       PROTOTYPE PS PLAN ACCOUNT
       #206-08291-12445

YOCUM CONSULTING ASSOCIATES, INC.

VOLUNTEER HEALTHCARE ASSOCIATES, L.L.C
MCDONALD INVESTMENTS INC. CUSTODIAN
       FBO S. STERLING MCMILLAN III IRA
       ROLLOVER ACCOUNT #85362191
RONALD G. KALISH LIVING TRUST U/A/D
       SEPTEMBER 9, 1997
LOIS F. MARLER
MCDONALD INVESTMENTS INC. CUSTODIAN
       FBO DANIEL J. BOYLE IRA
       ROLLOVER ACCOUNT #85314893
NATIONAL CITY BANK OF MI/IL CUSTODIAN
       FBO HERBERT S. AMSTER IRA
       ROLLOVER ACCOUNT DATED JUNE 12, 1991
       #MI-1491-00-4
KANTNER AND ASSOCIATES PROFIT SHARING
       PLAN U/A/D JANUARY 1, 1991
MICHAEL G. WILLIAMS

By:  White Pines Management, L.L.C.,
     a Michigan limited liability
     company, attorney-in-fact

By:  /s/ Frederick L. Yocum
     ----------------------------
     Frederick L. Yocum, Chairman

                                       8

<PAGE>   18

                                                                    AMEND. 1-RRA

                                                                     Page 2 of 2

                                 APRIL LENDERS

CHASE VENTURE CAPITAL ASSOCIATES, L.P.

By: /s/ Damion Wicker
   -----------------------------

AMERICAN HEALTHCARE FUND II
By: Capital Health Venture Partners
    Its General Partners

By: /s/ Dan J. Mitchell
    -------------------------------
    Dan J. Mitchell
    General Partner

/s/ J. Matthew Mackowski
--------------------------------
J. MATTHEW MACKOWSKI

/s/ Robert G. Shepler
--------------------------------
ROBERT G. SHEPLER

/s/ John J. Mackowski
--------------------------------
JOHN J. MACKOWSKI

GROVE INVESTMENT PARTNERS

By: /s/ John K. Kerr
   -----------------------------

                                       9
<PAGE>   19

                                                                     Page 1 of 2

                                OCTOBER LENDERS

WHITE PINES LIMITED PARTNERSHIP I
By:  White Pines G.P., L.L.C.,
     it's  general partner

By:  /s/ Frederick L. Yocum
     ----------------------------
     Frederick L. Yocum, Chairman

PACIFIC CAPITAL, L.P.
By:  WP Pacific G.P., L.L.C.
     a general partner

By:  /s/ Frederick L. Yocum
     ----------------------------
     Frederick L. Yocum, Chairman

IAN R. N. BUND
YOCUM CONSULTING ASSOCIATES, INC.
VOLUNTEER HEALTHCARE ASSOCIATES, L.L.C
RONALD G. KALISH LIVING TRUST U/A/D
     SEPTEMBER 9, 1997
McDONALD INVESTMENTS INC. CUSTODIAN
     FBO DANIEL J. BOYLE IRA ROLLOVER
     ACCOUNT #85314893
KANTNER AND ASSOCIATES PROFIT SHARING
     PLAN U/A/D JANUARY 1 1991
MICHAEL G. WILLIAMS

By:  White Pines Management, L.L.C.,
     a Michigan limited liability
     company, attorney-in-fact

By:  /s/ Frederick L. Yocum
     ----------------------------
     Frederick L. Yocum, Chairman

CHASE VENTURE CAPITAL ASSOCIATES, L.P.

By: /s/Damion Wicker
    -----------------------------

American Healthcare Fund II, L.P.

By: Capital Health Venture Partners
    Its General Partners

By: /s/Dan J. Mitchell
    -----------------------------
    Dan J. Mitchell
    General Partner

                                       10

<PAGE>   20

                                                                  AMEND. 1 - RRA

                                                                     Page 2 of 2
                                OCTOBER LENDERS

/s/ J. MATTHEW  MACKOWSKI
---------------------------
J. MATTHEW  MACKOWSKI

/s/ ROBERT G. SHEPLER
---------------------------
ROBERT G. SHEPLER

/s/ JOHN J.  MACKOWSKI
---------------------------
JOHN J.  MACKOWSKI

GROVE INVESTMENT PARTNERS

By: /s/ John K. Kerr
   ------------------------

/s/ LAWRENCE J. KENT
---------------------------
LAWRENCE J. KENT

/s/ JEFFREY S. WILLIAMS
---------------------------
JEFFREY S. WILLIAMS

/s/ KEVIN A. AUTON
---------------------------
KEVIN A. AUTON

/s/ ANDREW A. JAKIMCIUS
---------------------------
ANDREW A. JAKIMCIUS

/s/ MICHAEL P. KUREK
---------------------------
MICHAEL P. KUREK

/s/ STEVEN J. RICHVALSKY
---------------------------
STEVEN J. RICHVALSKY<PAGE>   1
                                                                     EXHIBIT 4.9

Date of Issuance: October 13, 1998

                                                                Warrant No.
                                                                            ----

                    THIS WARRANT AND THE WARRANT SHARES HAVE
                  NOT BEEN REGISTERED UNDER THE SECURITIES ACT
                OF 1933, AS AMENDED, NOR REGISTERED OR QUALIFIED
                  UNDER ANY STATE SECURITIES LAWS, AND MAY NOT
                   BE PLEDGED, HYPOTHECATED, SOLD, TRANSFERRED
                  OR OTHERWISE DISPOSED OF UNLESS SO REGISTERED
                     OR AN EXEMPTION THEREFROM IS AVAILABLE

                        WARRANT TO PURCHASE COMMON STOCK
                                       OF
                             GENOMIC SOLUTIONS INC.

         THIS CERTIFIES THAT, for value received, ESA, Inc., a Massachusetts
corporation (the "Holder"), is entitled to purchase from Genomic Solutions Inc.,
a Delaware corporation (the "Company"), at the exercise price of Six Dollars
($6.00) per share (the "Exercise Price"), One Hundred Twenty Five Thousand
(125,000) shares (subject to adjustment as provided in Section 5 hereof) of the
Company's common stock, par value $.001 (the "Common Stock").

         SECTION 1. TERM OF WARRANT, RESTRICTIONS ON TRANSFER, EXERCISE OF
WARRANT.

         SECTION 1.1. TERM OF WARRANT. Subject to the terms of this Warrant, the
Holder shall have the right, at the Holder's option, which may be exercised in
whole or in part (but only in quantities of 25,000 shares), at any time and from
time to time after the Date of Issuance, but before the date ten (10) years
after the Date of Issuance (the "Warrant Expiration Date"), to purchase from the
Company the number of fully paid and nonassessable shares of the Common Stock
that the Holder may at the time be entitled to purchase on exercise of this
Warrant (the "Warrant Shares"). After such time, this Warrant shall become null
and void.

         SECTION 1.2. RESTRICTIONS ON TRANSFER. This Warrant is not transferable
without the prior written consent of the Company, except that upon providing
prior written notice to the Company and subject to compliance with federal and
state securities laws as determined by the Company, Holder may assign this
Warrant to (i) any or all of Holders' shareholders of record at the time of
assignment; or (ii) any or all of Holders' senior executives as they exist at
the time of assignment. The Warrant and the Warrant Shares will be restricted
securities as defined under the Securities Act of 1933, as amended (the "Act")
and therefore will also not be transferable except in compliance with applicable
federal and state securities laws, unless the proposed disposition is the
subject of a Federal currently effective registration statement under the Act or
unless the Company has received an opinion of counsel, in the form and substance
reasonably satisfactory to the Company to the effect that such registration is
not required in connection with such disposition. Unless the Warrant Shares
shall have been duly registered under the Act and any applicable state
securities laws, certificates representing such shares

                                       1
<PAGE>   2

shall bear a legend comparable to the legend set forth above regarding
restrictions on transfer. Additionally, each certificate representing the
Warrant Shares shall bear the following legend:

                  The sale, transfer, assignment, pledge, hypothecation, or
                  other disposition of the shares represented by this
                  certificate is restricted by the provisions of the
                  Shareholders Agreement, dated as of December 24, 1997, as it
                  may be amended from time to time, to which the Company and the
                  holder of this certificate, among others, are parties, a copy
                  of which may be inspected at the principal office of the
                  Company. The provisions of such agreement are incorporated
                  herein by reference.

         SECTION 1.3. EXERCISE OF WARRANT. This Warrant may be exercised upon
surrender hereof to the Company at its principal office, together with the
Purchase Form attached hereto duly filled in and signed, and upon payment by
certified check or wire transfer to the Company of the Exercise Price for each
share to be purchased.

         SECTION 1.4. CERTIFICATE ISSUANCE. Subject to Section 1.2 and to
Section 2 hereof, upon such surrender of this Warrant and payment of the
Exercise Price, the Company shall issue and cause to be delivered with all
reasonable dispatch to or upon the written order of the Holder a certificate or
certificates for the number of full Warrant Shares so purchased upon the
exercise of this Warrant. Such certificate or certificates shall be deemed to
have been issued and any person so designated to be named therein shall be
deemed to have become a holder of record of such Warrant Shares as of the date
of the surrender of this Warrant and payment of the Exercise Price.

         SECTION 1.5. PARTIAL EXERCISE. In the event this Warrant is not
exercised in full, the Company, at its expense, shall forthwith issue and
deliver to, or upon the order of, Holder a new Warrant of like tenor in the name
of Holder or any permitted assignee (upon payment by Holder of any applicable
transfer taxes), calling in the aggregate on the face thereof for the number of
shares of Common Stock equal (without giving effect to any adjustment therein)
to (i) the number of such shares called for on the face of this Warrant minus
(ii) the number of such shares for which this Warrant shall have been exercised
(without giving effect to any adjustment in number as a result of changes called
for by Section 5).

         SECTION 2. PAYMENT OF TAXES. The Company will pay all documentary stamp
taxes, if any, attributable to the initial issuance of any Warrant Shares upon
the exercise of this Warrant; provided, however, that the Company shall not be
required to pay any tax or taxes which may be payable in respect of any transfer
involved in the issue or delivery of any Warrant or certificate for Warrant
Shares in a name other than that of the Holder of this Warrant as such name is
then shown on the books of the Company.

         SECTION 3. MUTILATED OR MISSING WARRANT. Upon receipt of evidence
satisfactory to the Company of the loss, theft, destruction or mutilation of
this Warrant and, in the case of any such loss, theft or destruction, upon
receipt of reasonably satisfactory indemnification or, in the case of any such
mutilation, upon surrender and cancellation of such Warrant, the Company will
make and deliver, in lieu of such lost, stolen, destroyed or mutilated Warrant,
a new Warrant of like tenor and representing

                                       2
<PAGE>   3

the right to purchase the same aggregate number of Warrant Shares. Any such new
Warrant executed and delivered shall constitute an additional contractual
obligation on the part of the Company, whether or not the Warrant so lost,
stolen, destroyed or mutilated shall be at any time enforceable by anyone.

         SECTION 4. CERTAIN COVENANTS.

         SECTION 4.1. RESERVATION OF WARRANT SHARES. There have been reserved,
and the Company shall at all times keep reserved, out of its authorized Common
Stock, a number of shares of Common Stock sufficient to provide for the exercise
of the rights of purchase represented by this Warrant. Any transfer agent for
the Common Stock and any successor transfer agent for the Common Stock is hereby
irrevocably authorized to cause to be issued from time to time the share
certificates required to honor this Warrant upon its exercise in accordance with
the terms hereof. The Company will supply any such transfer agent with duly
executed share certificates for such purpose.

         SECTION 4.2. NO IMPAIRMENT. The Company shall not by any action,
including, without limitation, amending its Amended and Restated Certificate of
Incorporation, as amended, any reorganization, transfer of assets,
consolidation, merger, dissolution, issue or sale of securities or any other
voluntary action, avoid or seek to avoid the observance or performance of any of
the terms of this Warrant, but will at all times in good faith assist in the
carrying out of all such terms and in the taking of all such action as may be
necessary or appropriate to protect the rights of the Holder against impairment.
Without limiting the generality of the foregoing, the Company will (a) take all
such action as may be necessary or appropriate in order that the Company may
validly issue fully paid and nonassessable Common Stock upon the exercise of
this Warrant and (b) obtain all such authorizations, exemptions or consents from
any public regulatory body having jurisdiction thereof as may be necessary to
enable the Company to perform its obligations under this Warrant.

         SECTION 5. ANTI-DILUTION AND OTHER ADJUSTMENT PROVISIONS.

         SECTION 5.1. COMMON STOCK DIVIDENDS, SUBDIVISIONS, COMBINATIONS. If the
Company shall: (a) pay or make a dividend or other distribution to all holders
of its Common Stock in shares of Common Stock, (b) subdivide, split or
reclassify the outstanding shares of its Common Stock into a larger number of
shares, or (c) combine or reclassify the outstanding shares of its Common Stock
into a smaller number of shares, then in each case the number of Warrant Shares
shall be adjusted to equal the number of such shares to which the Holder of this
Warrant would have been entitled upon the occurrence of such event had this
Warrant been exercised immediately prior to the happening of such event or, in
the case of a stock dividend or other distribution, prior to the record date for
determination of shareholders entitled thereto. An adjustment made pursuant to
this Section 5.1 shall become effective immediately after such record date, in
the case of a dividend or distribution, and immediately after the effective
date, in the case of a subdivision, split, combination or reclassification.
Whenever any adjustment is required to be made to the number of Warrant Shares,
the Exercise Price shall be changed to the number determined by dividing (i)
$750,000, or the appropriate prorated amount if partial exercise has occurred,
by (ii) the number of Warrant Shares immediately after such adjustment.

         SECTION 5.2. REORGANIZATION OR RECLASSIFICATION. In case of any capital
reorganization or any reclassification of the Common Stock of the Company
(whether pursuant to a merger or

                                       3
<PAGE>   4

consolidation or otherwise), this Warrant shall thereafter be exercisable for
the number of shares of stock or other securities or property receivable upon
such capital reorganization or reclassification of Common Stock, as the case may
be, by a Holder of the number of shares of Common Stock for which this Warrant
was exercisable immediately prior to such capital reorganization or
reclassification of Common Stock; and, in any case, appropriate adjustment shall
be made in the application of the provisions herein set forth with respect to
the rights and interests thereafter of the Holder of this Warrant such that the
provisions set forth herein shall thereafter be applicable, as nearly as
reasonably may be, in relation to any shares of stock or other securities or
property thereafter deliverable upon the exercise of this Warrant. The Company
shall not effect any such reorganization, consolidation, merger or sale unless,
prior to or contemporaneously with the consummation thereof: (i) the successor
corporation (if other than the Company) resulting from such consolidation or
merger or the corporation or other person purchasing assets shall assume by
written instrument executed and delivered to Holder, the obligation to deliver
to Holder such securities or property as, in accordance with the foregoing
provisions, Holder may be entitled to purchase or receive; or (ii) if the
successor corporation will not assume such obligation, upon twenty days' prior
written notice by the Company to the Holder of the Holder's right to exercise
the Warrant, which right may be exercised upon payment of the Aggregate Exercise
Price to the Company in exchange for the Warrant Shares or the surrender of the
Warrant to the Company and the Company's payment to the Holder in immediately
available funds of the Aggregate Fair Market Value in excess of the Aggregate
Exercise Price. For purposes of this Section, "Aggregate Exercise Price means an
amount equal to the product of the Exercise Price multiplied by the number of
Warrant Shares being purchased and surrendered for payment at such time. "Fair
Market Value" means, on any given date, the fair market value of the Common
Stock as determined in good faith by the Board of Directors; provided, however,
that: (a) if the Common Stock is admitted to quotation on the National
Association of Securities Dealers Automated Quotation System ("Nasdaq") SmallCap
Market on the date the Warrant is exercised, the Fair Market Value means the
average of the highest bid and lowest asked prices of the Common Stock on Nasdaq
reported for such date; (b) if the Common Stock is admitted to trading on a
national securities exchange or the Nasdaq National Market on the date the
Warrant is exercised, the Fair Market Value means the closing price reported for
the Common Stock on such exchange or system for such date or, if no sales were
reported for such date, for the last date preceding such date for which a sale
was reported; and (c) the Fair Market Value of the Common Stock on the effective
date of the registration statement for the Company's initial public offering
shall be the initial offering price. For purposes of this Section, the
"Aggregate Fair Market Value" means an amount equal to the product of the Fair
Market Value multiplied by the number of Warrant Shares being surrendered to the
Company at such time.

         SECTION 5.3. NOTICE OF CERTAIN CORPORATE TRANSACTIONS. The Company
shall promptly mail to the Holder a notice of any proposed action referred to in
Sections 4.2, 5.1 or 5.2 hereof, stating the proposed record date (if any) or
effective date for any such transaction and briefly describing the transaction.

         SECTION 5.4. NO ADJUSTMENT OR READJUSTMENT IN CERTAIN CIRCUMSTANCES.
The Company shall not make any adjustment or readjustment of the number of
Warrant Shares in the case of: (a) the exercise of this Warrant, or (b) by
reason of the issuance of shares of Common Stock or any other securities of the
Company in exchange for cash, property or services or other consideration.

                                       4
<PAGE>   5

         SECTION 5.5. CERTIFICATE OF ADJUSTMENT. Upon the occurrence of each
adjustment or readjustment pursuant to this Section 5, the Company, at its
expense, shall as promptly as practicable compute such adjustment or
readjustment in accordance with the provisions of this Section 5, and prepare
and furnish to the Holder a certificate setting forth such adjustment or
readjustment and showing in reasonable detail the facts upon which such
adjustment or readjustment is based. At its option, Holder may confirm such
adjustment by causing such adjustment to be completed by an independent
certified public accountant at the expense of the Holder.

         SECTION 6. REGISTRATION RIGHTS.

         SECTION 6.1 COMPANY REGISTRATION.

                  (a) Subject to certain limitations set forth in subsection (b)
of this Section, if the Company proposes to register any of its stock or other
securities under the Act in connection with the public offering of such
securities solely for cash (other than in a registration relating solely to the
sale of securities to participants in a Company stock option plan, or a
registration on any form which does not include substantially the same
information as would be required to be included in a registration statement
covering the sale of the securities or a SEC Rule 145 transaction), the Company
shall, at such time, promptly give the Holder written notice of the Company's
intention to effect such a registration (a "Piggyback Notice"). In the event the
Company receives a written request from the Holder not more than fifteen (15)
days after the mailing of the Piggyback Notice, the Company shall, subject to
the provisions of Sections 6.1 and 6.2, include in such filing and shall use its
best efforts to register the Warrant Shares as to which the Holder requested
registration, provided, however, if at any time after giving written notice of
its intention to register any equity securities and prior to the effective date
of the registration statement filed in connection with such registration, the
Company shall determine for any reason not to register such equity securities,
the Company may, at its election, give written notice of such determination to
the Holder and, thereupon, shall be relieved from its obligation with such
registration (but not from its obligation to pay the registration expenses in
connection therewith). Notwithstanding the foregoing, after the Company's
initial public offering, the Company will not be required to include the Warrant
Shares in an offering or to provide the Holder with a Piggyback Notice if the
underwriters have advised the Company in writing that in their judgment market
conditions will not allow the inclusion of any shares for resale by the
Company's stockholders in such offering.

         (b) The registration rights granted to the Holder pursuant to Section
6.1(a) above are subordinate and subject to the rights of the holders of the
Company's Series M Preferred Stock, Series B Preferred Stock, Series C Preferred
Stock and Series D Preferred Stock (collectively, the "Preferred Stock"), as
more particularly described in the Shareholders Agreement, as amended, between
the Company and certain of its stockholders, dated as of December 24, 1997. The
Company shall be required to include the Warrant Shares in any registration only
to the extent that such inclusion will not reduce the amount of securities to be
registered and sold by the holders of Preferred Stock. If the managing or
principal underwriters named in the registration statement advise the Company
that, in the good faith judgment of such managing or principal underwriters, the
number of shares of Common Stock which the Holder, the Company and all other
shareholders have requested to be included in such registration statement exceed
the number of shares it is advisable to offer and to sell at such time, then the
Company shall include in such registration, to the extent of the number of
shares of Common Stock

                                       5
<PAGE>   6

which the Company is so advised can be sold in such offering, the shares of
Common Stock that the Company proposes to issue and sell for its own account,
the shares of Common Stock requested to be registered and sold by the holders of
Preferred Stock and the number of shares of Common Stock to be registered and
sold by the Holder and all other shareholders requesting registration; provided,
however, that the shares of Common Stock requested to be registered and sold by
the Holder and the shares of Common Stock requested to be registered by those
shareholders (the "Investors") pursuant to the Investor Agreement between the
Company and the former shareholders of PBA Technology Limited, dated as of
December 31, 1997 shall be appropriately reduced. In such case the number of
shares of Common Stock to be registered and sold by the Holder and the Investor
after such reduction shall be apportioned pro rata among the Holder and the
Investors according to the total amount of securities owned by the Holder and
each Investor or in such other proportions as shall be mutually agreed to by the
Holder and the Investors.

                  (c) The Holder hereby agrees that for a period of 180 days
following the effective date of the first registration statement of the Company
covering Common Stock filed on Form S-l under the Act and for any registration
effected pursuant to Section 6.1(a) above, provided the Holders are given
written notice of the offering at least fifteen (15) days prior to the Company's
filing with the SEC of a registration statement relating thereto), it shall not,
unless otherwise agreed by the Company and the managing underwriters, directly
or indirectly sell, offer to sell, contract to sell (including, without
limitation, any short sale), grant any option to purchase or otherwise transfer
or dispose of (other than to donees who agree to be similarly bound) any
securities of the Company held by it at any time during such period except
Common Stock included in such registration.

         SECTION 6.2. OTHER PROVISIONS RELATING TO REGISTRATION RIGHTS. In
connection with any registration pursuant to this Section 6:

                  (a) Upon the request of the Holder of the Warrant Shares then
being registered, the Company shall cooperate with any underwriters (as defined
in the Act) for the Holder, including, without limitation, providing such
information, certificates, comfort letters of accountants and opinions of
counsel as may be customarily and reasonably requested by such underwriters;
provided that any underwriters for the Holder must be approved by the Company
(which approval shall not be unreasonably withheld).

                  (b) The Company shall furnish to the Holder of the Warrant
Shares being registered, at the Company's sole cost and expense, such number of
prospectuses conforming to the requirements of the Act, and the rules and
regulations thereunder, relating to the Warrant Shares subject thereto as may
from time to time be reasonably requested by such holders.

                  (c) All fees, disbursements and expenses incident to the
Company's performance of or compliance with its obligations under this Section 6
shall be borne by the Company, including, without limitation, all registration
and filing fees, printing expenses, fees and disbursements of counsel for the
Company and expenses of complying with applicable securities or blue sky laws.

                  (d) The Company agrees to use its best efforts at its own
expense to effect and to keep effective necessary registrations or
qualifications under the securities or Blue Sky laws of such

                                       6
<PAGE>   7

jurisdictions as may be reasonably requested by any of the holders of the
Warrant Shares or by any underwriters for such holders so as to permit the
disposition of the Warrant Shares being registered.

                  (e) The Holder agrees to provide in an expeditious manner
whatever information and undertakings are reasonably requested by the Company in
order to comply with the requirements of the Act and of the Securities Exchange
Act of 1934, as amended, the rules and regulations thereunder and the guides and
other pronouncements of the Commission in connection with the registration of
the Holder's Warrant Shares.

                  (f) The Company shall indemnify and hold harmless the Holder
and any underwriter (as defined in the Act) who participates in such
registration for such Holder and each person, if any, who controls the Holder or
any underwriter against any losses, claims, damages or liabilities, joint or
severally, or actions in respect thereof to which the Holder or any underwriter
or controlling person may become subject under the Act, or otherwise, insofar as
such losses, claims damages, liabilities or actions in respect thereof arise out
of, or are based upon, any untrue statement or alleged untrue statement of any
material fact contained in any registration statement under which such Warrant
Shares were registered under the Act, any preliminary prospectus or final
prospectus contained therein, or any amendment or supplement thereto, or arise
out of, or are based upon the omission or alleged omission to state therein a
material fact required to be stated therein or necessary to make the statements
therein not misleading, and will reimburse the Holder or any underwriter or
controlling person for any legal or other expenses reasonably incurred by them
in connection with investigating or defending any such loss, claim, damage,
liability or action; provided, however, that the Company shall have the right,
at its option, to defend at its expense and by its own counsel against any
losses, claims, damages or liabilities, provided that (i) such counsel is
reasonably satisfactory to the Holder of the Warrant Shares; (ii) the Holder of
the Warrant Shares is kept fully informed of all developments, and is furnished
with copies of all documents and papers, related thereto and is given the right
to participate in the defense and investigation thereof at the expense of the
Company if (A) in the written opinion of counsel to such holders, use of counsel
of the Company's choice would be expected to give rise to a conflict of
interest; (B) there are or may be legal defenses available to the Holder that
are different from or additional to those available to the Company; (C) the
Company shall not have employed counsel to represent the Holder within a
reasonable time after notice of such claim is given to the Company or notice
that the Company intends to assume the defense of such claim is given to the
Holder; or (D) the Company shall authorize the Holder to employ separate counsel
at the expense of the Company; and provided, further, that to the extent that
any such loss, claim, damage or liability arises out of, or is based upon, an
untrue statement or alleged untrue statement or omission or alleged omission
made in said registration statement, said preliminary prospectus or said final
prospectus in conformity with written information furnished to the Company by
the Holder specifically for use in the preparation thereof, the Company will not
be so liable to the Holder or underwriter and the Holder agrees to indemnify and
hold the Company harmless from any loss, claim, damage, liability or action
arising from such information furnished to the Company by it and to use
reasonable efforts to cause any underwriter for the Holder to indemnify and hold
the Company harmless from any loss, claim, damage, liability or action arising
from information furnished to the Company by such underwriter; provided that
Holder's indemnification obligations will be limited to Holder's proceeds from
such registration.

                  (g) The Holder shall not be required to make any
representations or warranties

                                       7
<PAGE>   8

to or agreements with the Company or the underwriters other than customary
representations, warranties or agreements regarding the Holder, the Holder's
Warrant Shares and the Holder's intended method of distribution and any other
representation required by law.

         SECTION 7. TERMINATION OF RESTRICTIONS. The restrictions imposed by
Section 1.2 hereof upon the transferability of any Warrant Shares shall cease
and terminate as to any Warrant Shares (a) when such securities shall have been
effectively registered under the Act and any applicable state securities laws
and disposed of in accordance with the registration statement(s) covering such
securities, or (b) when, in the opinions of both counsel for the Holder and
counsel for the Company, such restrictions are no longer required in order to
insure compliance with the Act and applicable state securities laws. Whenever
such restrictions shall terminate as to any Warrant Shares, the Holder shall be
entitled to receive from the Company, without expense (other than transfer
taxes, if any), new securities of like tenor not bearing a legend as to
restrictions on transfer.

         SECTION 8. NO RIGHTS AS A SHAREHOLDER. Nothing contained in this
Warrant shall be construed as conferring upon the Holder the right to vote or to
receive dividends or to consent or to receive notice as a shareholder in respect
of any meeting of shareholders for the election of directors of the Company or
any other matter, or any rights whatsoever as a shareholder of the Company.

         SECTION 9. REPRESENTATIONS AND WARRANTIES. The Company hereby
represents and warrants to the Holder as follows:

                  (a) The Company is a corporation duly organized, validly
         existing and in good standing under the laws of the State of Delaware;

                  (b) The Company has the full corporate power and authority to
         execute, deliver and issue this Warrant and to carry out its
         obligations hereunder;

                  (c) The execution, delivery and issuance of this Warrant and
         the performance of the obligations hereunder have been duly authorized
         by all necessary corporate action on the part of the company and this
         warrant has been duly executed and delivered and constitutes the valid
         and legally binding obligation of the Company, enforceable against it
         in accordance with its terms; and

                  (d) The Warrant Shares will, when issued pursuant to this
         Warrant, be duly authorized and validly issued, fully paid and
         nonassessable.

         SECTION 10. NOTICES. Any notice pursuant to this Warrant by the Company
or by the Holder shall be in writing and shall be mailed first class, postage
prepaid, or delivered (a) to the Company, at its principal office at 4355
Varsity Drive, Suite E, Ann Arbor, Michigan 48108, or (b) to the Holder, at its
address as indicated in the books and records of the Company. Either party may
from time to time change the address to which notices to it are to be delivered
or mailed under this Warrant by notice in writing to the other party.

                                       8
<PAGE>   9

         SECTION 11. SUCCESSORS. All the covenants and provisions of this
Warrant by or for the benefit of the Company or the Holder shall bind and inure
to the benefit of their respective successors and assigns.

         SECTION 12. APPLICABLE LAW; ENTIRE AGREEMENT. This Warrant shall be
governed by and construed in accordance with the laws of the State of Delaware
without giving effect to principles of conflict of laws. This Warrant shall be
deemed to be the complete and final expression of the agreement between the
parties with respect to the subject matter hereof.

         SECTION 13. CAPTIONS. The captions of the Sections and subsections of
this Warrant have been inserted for convenience only and shall have no
substantive effect.

         IN WITNESS WHEREOF, the undersigned has executed this Warrant this
13th day of October, 1998.

                                        GENOMIC SOLUTIONS INC., a Delaware
                                        corporation

                                        By: /s/ Jeffrey S. Williams
                                           -------------------------------------
                                             Jeffrey S. Williams
                                        Its: President and Chief Executive
                                             Officer

                                       9

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