Document:

Third Amended and Restated Investor Rights Agreement

 Exhibit 10.6 
 PORTOLA PHARMACEUTICALS, INC. 
 THIRD AMENDED AND RESTATED INVESTOR
RIGHTS AGREEMENT 
 November 18, 2011 

 TABLE OF CONTENTS 

 

							
	 	  	 	  	PAGE	 
			
	SECTION 1.	  	 GENERAL
	  	 	1	  
			
	1.1  	  	 Definitions
	  	 	2	  
			
	SECTION 2.	  	 REGISTRATION; RESTRICTIONS ON TRANSFER
	  	 	3	  
			
	2.1  	  	 Restrictions on Transfer
	  	 	3	  
			
	2.2  	  	 Demand Registration
	  	 	5	  
			
	2.3  	  	 Piggyback Registrations
	  	 	6	  
			
	2.4  	  	 Form S-3 Registration
	  	 	7	  
			
	2.5  	  	 Expenses of Registration
	  	 	8	  
			
	2.6  	  	 Obligations of the Company
	  	 	9	  
			
	2.7  	  	 Termination of Registration Rights
	  	 	10	  
			
	2.8  	  	 Delay of Registration; Furnishing Information
	  	 	11	  
			
	2.9  	  	 Indemnification
	  	 	11	  
			
	2.10	  	 Assignment of Registration Rights
	  	 	13	  
			
	2.11	  	 Amendment of Registration Rights
	  	 	14	  
			
	2.12	  	 Limitation on Subsequent Registration Rights
	  	 	14	  
			
	2.13	  	 “Market Stand-Off” Agreement
	  	 	14	  
			
	2.14	  	 Agreement to Furnish Information
	  	 	14	  
			
	2.15	  	 Rule 144 Reporting
	  	 	15	  
			
	SECTION 3.	  	 COVENANTS OF THE COMPANY
	  	 	15	  
			
	3.1  	  	 Basic Financial Information and Reporting
	  	 	15	  
			
	3.2  	  	 Inspection Rights
	  	 	16	  
			
	3.3  	  	 Confidentiality of Records
	  	 	16	  
			
	3.4  	  	 Reservation of Common Stock
	  	 	16	  
			
	3.5  	  	 Stock Vesting
	  	 	17	  
			
	3.6  	  	 Key Man Insurance
	  	 	17	  
			
	3.7  	  	 Proprietary Information and Inventions Agreement
	  	 	17	  
			
	3.8  	  	 Assignment of Right of First Refusal
	  	 	17	  
			
	3.9  	  	 Directors’ Expenses
	  	 	17	  
			
	3.10	  	 Directors’ Liability and Indemnification
	  	 	17	  
			
	3.11	  	 Board Observers
	  	 	17	  

  
 i. 

 TABLE OF CONTENTS 

(CONTINUED) 
  

							
	 	  	 	  	PAGE	 
			
	 3.12
	  	 Termination of Covenants
	  	 	18	  
			
	 SECTION 4.
	  	 RIGHTS OF FIRST REFUSAL
	  	 	18	  
			
	 4.1  
	  	 Subsequent Offerings
	  	 	18	  
			
	 4.2  
	  	 Exercise of Rights
	  	 	18	  
			
	 4.3  
	  	 Issuance of Equity Securities to Other Persons
	  	 	19	  
			
	 4.4  
	  	 Sale Without Notice
	  	 	19	  
			
	 4.5  
	  	 Termination and Waiver of Rights of First Refusal
	  	 	19	  
			
	 4.6  
	  	 Transfer of Rights of First Refusal
	  	 	19	  
			
	 4.7  
	  	 Excluded Securities
	  	 	19	  
			
	 SECTION 5.
	  	 MISCELLANEOUS
	  	 	20	  
			
	 5.1  
	  	 Amendment and Restatement
	  	 	20	  
			
	 5.2  
	  	 Governing Law
	  	 	21	  
			
	 5.3  
	  	 Successors and Assigns
	  	 	21	  
			
	 5.4  
	  	 Entire Agreement
	  	 	21	  
			
	 5.5  
	  	 Severability
	  	 	21	  
			
	 5.6  
	  	 Amendment and Waiver
	  	 	21	  
			
	 5.7  
	  	 Delays or Omissions
	  	 	22	  
			
	 5.8  
	  	 Notices
	  	 	22	  
			
	 5.9  
	  	 Attorneys’ Fees
	  	 	22	  
			
	 5.10
	  	 Titles and Subtitles
	  	 	22	  
			
	 5.11
	  	 Additional Investors
	  	 	22	  
			
	 5.12
	  	 Counterparts
	  	 	23	  
			
	 5.13
	  	 Aggregation of Stock
	  	 	23	  
			
	 5.14
	  	 Pronouns
	  	 	23	  
			
	 5.15
	  	 Consent and Waiver of Prior Investors
	  	 	23	  

  
 ii.

 PORTOLA PHARMACEUTICALS, INC. 

THIRD AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT 
 THIS THIRD AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT (the
“Agreement”) is entered into as of the 18th day of November, 2011, by and among PORTOLA PHARMACEUTICALS, INC., a Delaware corporation (the
“Company”), and the investors listed on Exhibit A hereto, referred to hereinafter as the “Investors” and each individually as an “Investor.” 

RECITALS 
 WHEREAS, certain of the Investors (the “Prior Investors”) are holders of the Company’s Series A Preferred Stock (the “Series A
Stock”), Series B Preferred Stock (the “Series B Stock”), and/or Series C Preferred Stock (the “Series C Stock,” where the the Series A Stock, the Series B Stock, the Series C Stock,
the Series 1 Stock (as defined below) and the Series D Stock (as defined below) shall be referred to herein collectively as the “Preferred Stock”) and are parties to that certain Second Amended and Restated Investor Rights
Agreement dated as of April 30, 2007, as amended (the “Prior Agreement”); 

WHEREAS, the Company and the Prior Investors desire to amend and restate the Prior Agreement as set
forth herein and to receive the rights created pursuant to this Agreement in lieu of the rights granted under the Prior Agreement; 
 WHEREAS, certain of the Investors are purchasing shares of the Company’s Series D Preferred Stock (the “Series D Stock”) on the date hereof
pursuant to that certain Series D Preferred Stock Purchase Agreement dated November 11, 2011 (the “Series D Purchase Agreement”); 
 WHEREAS, certain of the Investors will be purchasing shares of the Company’s Series 1 Preferred Stock (the “Series 1 Stock”) on a date later
than the date hereof pursuant to that certain Series 1 Preferred Stock Purchase Agreement dated October 26, 2011 (the “Series 1 Purchase Agreement,” where the Series D Purchase Agreement and the Series 1 Purchase
Agreement shall be referred to herein collectively as the “Purchase Agreements”); 

WHEREAS, the obligations in the Purchase Agreements are conditioned upon the execution and delivery of this
Agreement; and 
 WHEREAS, in connection with the consummation of the transactions contemplated by the
Purchase Agreements, the parties desire to enter into this Agreement in order to grant registration, information rights and other rights to the Investors as set forth below. 
 NOW, THEREFORE, in consideration of the premises and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the
parties agree hereto as follows: 
 SECTION 1. GENERAL. 

  
 1. 

 1.1 Definitions. As used in this Agreement the following terms shall have the
following respective meanings: 
 (a) “Exchange Act” means the Securities Exchange Act of 1934,
as amended. 
 (b) “Form S-3” means such form under the Securities Act as in effect on the date
hereof or any successor or similar registration form under the Securities Act subsequently adopted by the SEC which permits inclusion or incorporation of substantial information by reference to other documents filed by the Company with the SEC.

 (c) “Holder” means any person owning of record Registrable Securities that have not been sold
to the public or any assignee of record of such Registrable Securities in accordance with Section 2.10 hereof, provided, however, that General Electric Capital Corporation (“GECC”) shall be deemed to be a
“Holder” solely with respect to Sections 2.3, 2.5, 2.6, 2.7, 2.8, 2.9, 2.10, 2.11, 2.13, 2.14, and 5 hereof and Hercules Technology Growth Capital (“Hercules”) shall be deemed to be a “Holder” solely with
respect to Sections 2 and 5 hereof and Biogen Idec MA Inc. (“Biogen”) shall be deemed to be a “Holder” solely with respect to Sections 2, 3.1(b), 3.1(c), 3.2 and 5 hereof. 

(d) “Initial Offering” means the Company’s first firm commitment underwritten public offering of its
Common Stock registered under the Securities Act in which all of the then-outstanding shares of the Company’s preferred stock are converted to Common Stock. 
 (e) “Register,” “registered,” and “registration” refer to a registration effected by preparing and filing a registration statement in
compliance with the Securities Act, and the declaration or ordering of effectiveness of such registration statement or document. 
 (f) “Registrable Securities” means (a) Common Stock of the Company issuable or issued upon conversion of the Shares, (b) any Common Stock of the Company issued as
(or issuable upon the conversion or exercise of any warrant, right or other security which is issued as) a dividend or other distribution with respect to, or in exchange for or in replacement of, such above-described securities, (c) shares of
Common Stock issued or issuable upon exercise of that certain Warrant to Purchase Shares of Preferred Stock issued to GECC dated as of January 21, 2005, solely with respect to Sections 2.3, 2.5, 2.6, 2.7, 2.8, 2.9, 2.10, 2.11, 2.13, 2.14, and 5
hereof, or (d) shares of Common Stock issued or issuable upon exercise of that certain Warrant to Purchase Shares of Preferred Stock issued to Hercules dated as of September 28, 2006, solely with respect to Sections 2 and 5 hereof.
Notwithstanding the foregoing, Registrable Securities shall not include any securities (i) sold by a person to the public either pursuant to a registration statement or Rule 144, (ii) sold in a private transaction in which the
transferor’s rights under Section 2 of this Agreement are not assigned or (iii) held by a Holder (together with its affiliates) if, as reflected on the Company’s list of stockholders of record, such Holder (together with its
affiliates) holds less than 1% of the Company’s outstanding Common Stock (treating all shares of Preferred Stock on an as converted basis), the Company has completed its Initial Offering and all shares of Common Stock of the Company issuable or
issued upon conversion of the Shares held by and issuable to such Holder (and its affiliates) may be sold pursuant to Rule 144 during any ninety (90) day period. 

  
 2. 

 (g) “Registrable Securities then outstanding” shall be the
number of shares of the Company’s Common Stock that are Registrable Securities and either (a) are then issued and outstanding or (b) are issuable pursuant to then exercisable or convertible securities. 

(h) “Registration Expenses” shall mean all expenses incurred by the Company in complying with
Sections 2.2, 2.3 and 2.4 hereof, including, without limitation, all registration and filing fees, qualification fees, printing and accounting expenses, fees and disbursements of counsel for the Company, reasonable fees and disbursements not to
exceed twenty-five thousand dollars ($25,000) of a single special counsel for the Holders, blue sky fees and expenses and the expense of any special audits incident to or required by any such registration (but excluding the compensation of regular
employees of the Company which shall be paid in any event by the Company). 
 (i) “SEC” or
“Commission” means the Securities and Exchange Commission. 
 (j) “Securities
Act” shall mean the Securities Act of 1933, as amended. 
 (k) “Selling Expenses”
shall mean all underwriting discounts and selling commissions applicable to the sale. 
 (l)
“Shares” shall mean the Company’s Preferred Stock held from time to time by the Investors listed on Exhibit A hereto and their permitted assigns. 

(m) “Special Registration Statement” shall mean (i) a registration statement relating to any employee
benefit plan or (ii) with respect to any corporate reorganization or transaction under Rule 145 of the Securities Act, including any registration statements related to the issuance or resale of securities issued in such a transaction or
(iii) a registration related to stock issued upon conversion of debt securities. 
 SECTION 2. REGISTRATION; RESTRICTIONS ON
TRANSFER. 
 2.1 Restrictions on Transfer. 
 (a) Each Holder agrees not to make any disposition of all or any portion of the Shares or Registrable Securities unless and until: 

(i) there is then in effect a registration statement under the Securities Act covering such proposed disposition and such
disposition is made in accordance with such registration statement; or 
 (ii) (A) the transferee has agreed in
writing to be bound by the terms of this Agreement, (B) such Holder shall have notified the Company of the proposed disposition and shall have furnished the Company with a statement of the proposed disposition, and (C) if reasonably
requested by the Company, such Holder shall have furnished the Company with an opinion of counsel, reasonably satisfactory to the Company, that such disposition will not require registration of such shares under the Securities Act. It is agreed that
the Company will not require opinions of counsel for transactions made pursuant to Rule 144, except in unusual 

  
 3. 

 
circumstances. After its Initial Offering, the Company will not require the transferee to be bound by the terms of this Agreement. 

(b) Notwithstanding the provisions of subsection (a) above, no such restriction shall apply to a transfer by a Holder that is
(A) a partnership transferring to its partners or former partners in accordance with partnership interests, (B) a corporation transferring to an entity that controls, is controlled by or is under common control with the Holder (an
“Affiliate”), (C) a limited liability company transferring to its members or former members in accordance with their interest in the limited liability company, (D) an individual transferring to the Holder’s
family member or trust for the benefit of an individual Holder, or (E) an entity transferring to any affiliate of such entity, including a limited partnership, fund, or other investment firm managed by or under common investment management with
such entity; provided that in each case the transferee will agree in writing to be subject to the terms of this Agreement to the same extent as if he were an original Holder hereunder. 

(c) Each certificate representing Shares or Registrable Securities shall be stamped or otherwise imprinted with legends
substantially similar to the following (in addition to any legend required under applicable state securities laws): 
 THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933 (THE “ACT”) AND MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED, ASSIGNED, PLEDGED OR
HYPOTHECATED UNLESS AND UNTIL REGISTERED UNDER THE ACT OR UNLESS THE COMPANY HAS RECEIVED AN OPINION OF COUNSEL SATISFACTORY TO THE COMPANY AND ITS COUNSEL THAT SUCH REGISTRATION IS NOT REQUIRED. 

THE SALE, PLEDGE, HYPOTHECATION OR TRANSFER OF THE SECURITIES REPRESENTED BY THIS CERTIFICATE IS SUBJECT TO THE TERMS AND
CONDITIONS OF A CERTAIN INVESTOR RIGHTS AGREEMENT BY AND BETWEEN THE STOCKHOLDER AND THE COMPANY. COPIES OF SUCH AGREEMENT MAY BE OBTAINED UPON WRITTEN REQUEST TO THE SECRETARY OF THE COMPANY. 

(d) The Company shall be obligated to reissue promptly unlegended certificates at the request of any Holder thereof if the Company
has completed its Initial Offering and the Holder shall have obtained an opinion of counsel (which counsel may be counsel to the Company) reasonably acceptable to the Company to the effect that the securities proposed to be disposed of may lawfully
be so disposed of without registration, qualification and legend. 
 (e) Any legend endorsed on an instrument pursuant to
applicable state securities laws and the stop-transfer instructions with respect to such securities shall be removed 

  
 4. 

 
upon receipt by the Company of an order of the appropriate blue sky authority authorizing such removal. 
 (f) Notwithstanding the provisions of paragraphs (a) and (b) above, the Company will not be obligated to effect any disposition of all or any portion of the Securities held by a Holder if
such disposition would require the Company to register securities pursuant to Section 12(g) of the Exchange Act. 
 2.2
Demand Registration. 
 (a) Subject to the conditions of this Section 2.2, if the Company shall receive a written
request from the Holders of a majority of the Registrable Securities (the “Initiating Holders”) that the Company file a registration statement under the Securities Act having an aggregate offering price to the public of not
less than ten million dollars ($10,000,000) (a “Qualified Public Offering”), then the Company shall, within thirty (30) days of the receipt thereof, give written notice of such request to all Holders, and subject to the
limitations of this Section 2.2, effect, as expeditiously as reasonably possible, the registration under the Securities Act of all Registrable Securities that all Holders request to be registered. 

(b) If the Initiating Holders intend to distribute the Registrable Securities covered by their request by means of an
underwriting, they shall so advise the Company as a part of their request made pursuant to this Section 2.2 or any request pursuant to Section 2.4 and the Company shall include such information in the written notice referred to in
Section 2.2(a) or Section 2.4(a), as applicable. In such event, the right of any Holder to include its Registrable Securities in such registration shall be conditioned upon such Holder’s participation in such underwriting and the
inclusion of such Holder’s Registrable Securities in the underwriting to the extent provided herein. All Holders proposing to distribute their securities through such underwriting shall enter into an underwriting agreement in customary form
with the underwriter or underwriters selected for such underwriting by a majority in interest of the Initiating Holders (which underwriter or underwriters shall be reasonably acceptable to the Company). Notwithstanding any other provision of this
Section 2.2 or Section 2.4, if the underwriter advises the Company in writing that marketing factors require a limitation of the number of securities to be underwritten (including Registrable Securities) then the Company shall so advise
all Holders of Registrable Securities which would otherwise be underwritten pursuant hereto, and the number of shares that may be included in the underwriting shall be allocated to the Holders of such Registrable Securities on a pro rata
basis based on the number of Registrable Securities held by all such Holders (including the Initiating Holders); provided, however, that the number of shares of Registrable Securities to be included in such underwriting and registration shall
not be reduced unless all other securities are first entirely excluded from the underwriting and registration. Any Registrable Securities excluded or withdrawn from such underwriting shall be withdrawn from the registration. 

(c) The Company shall not be required to effect a registration pursuant to this Section 2.2: 

(i) prior to one hundred eighty (180) days following the effective date of the registration statement pertaining to the
Initial Offering; 

  
 5. 

 (ii) after the Company has effected two (2) registrations pursuant to this
Section 2.2, and such registrations have been declared or ordered effective; 
 (iii) during the period starting
with the date of filing of, and ending on the date one hundred eighty (180) days following the effective date of the registration statement pertaining to a public offering, other than pursuant to a Special Registration Statement;
provided that the Company makes reasonable good faith efforts to cause such registration statement to become effective and provided, in the case of a public offering other than the Initial Offering, that the Initiating Holders were permitted
to register such shares as requested to be registered pursuant to Section 2.3 hereof without reduction by the underwriter thereof; 
 (iv) if within thirty (30) days of receipt of a written request from Initiating Holders pursuant to Section 2.2(a), the Company gives notice to the Holders of the Company’s intention
to file a registration statement for a public offering, other than pursuant to a Special Registration Statement within ninety (90) days; 
 (v) if the Company shall furnish to Holders requesting a registration statement pursuant to this Section 2.2, a certificate signed by the Chairman of the Board of Directors stating that in the
good faith judgment of the Board of Directors of the Company, it would be seriously detrimental to the Company and its stockholders for such registration statement to be effected at such time, in which event the Company shall have the right to defer
such filing for a period of not more than ninety (90) days after receipt of the request of the Initiating Holders; provided that such right to delay a request shall be exercised by the Company not more than once in any twelve
(12) month period; 
 (vi) if the Initiating Holders propose to dispose of shares of Registrable Securities that
may be immediately registered on Form S-3 pursuant to a request made pursuant to Section 2.4 below; or 

(vii) in any particular jurisdiction in which the Company would be required to qualify to do business or to execute a general
consent to service of process in effecting such registration, qualification or compliance. 
 2.3 Piggyback Registrations.
The Company shall notify all Holders of Registrable Securities in writing at least thirty (30) days prior to the filing of any registration statement under the Securities Act for purposes of a public offering of securities of the Company
(including, but not limited to, registration statements relating to secondary offerings of securities of the Company, but excluding Special Registration Statements) and will afford each such Holder an opportunity to include in such registration
statement all or part of such Registrable Securities held by such Holder. Each Holder desiring to include in any such registration statement all or any part of the Registrable Securities held by it shall, within fifteen (15) days after the
above-described notice from the Company, so notify the Company in writing. Such notice shall state the intended method of disposition of the Registrable Securities by such Holder. If a Holder decides not to include all of its Registrable Securities
in any registration statement thereafter filed by the Company, such Holder shall nevertheless continue to have the right to include any Registrable Securities in any subsequent registration statement or registration statements as may

  
 6. 

 
be filed by the Company with respect to offerings of its securities, all upon the terms and conditions set forth herein. 
 (a) Underwriting. If the registration statement under which the Company gives notice under this Section 2.3 is for an underwritten offering, the Company shall so advise the Holders of
Registrable Securities. In such event, the right of any such Holder to be included in a registration pursuant to this Section 2.3 shall be conditioned upon such Holder’s participation in such underwriting and the inclusion of such
Holder’s Registrable Securities in the underwriting to the extent provided herein. All Holders proposing to distribute their Registrable Securities through such underwriting shall enter into an underwriting agreement in customary form with the
underwriter or underwriters selected for such underwriting by the Company. Notwithstanding any other provision of this Agreement, if the underwriter determines in good faith that market conditions require a limitation of the number of shares to be
underwritten, the number of shares that may be included in the underwriting shall be allocated, first, to the Company; second, to the Holders on a pro rata basis based on the total number of Registrable Securities held by the Holders
participating in such underwriting; and third, to any stockholder of the Company (other than a Holder) on a pro rata basis. If any Holder disapproves of the terms of any such underwriting, such Holder may elect to withdraw therefrom by
written notice to the Company and the underwriter, delivered at least ten (10) business days prior to the effective date of the registration statement. Any Registrable Securities excluded or withdrawn from such underwriting shall be excluded
and withdrawn from the registration. For any Holder which is a partnership or corporation, the partners, retired partners and stockholders of such Holder, or the estates and family members of any such partners and retired partners and any trusts for
the benefit of any of the foregoing person shall be deemed to be a single “Holder,” and any pro rata reduction with respect to such “Holder” shall be based upon the aggregate amount of shares carrying registration rights
owned by all entities and individuals included in such “Holder,” as defined in this sentence. 
 (b) Right to
Terminate Registration. The Company shall have the right to terminate or withdraw any registration initiated by it under this Section 2.3 prior to the effectiveness of such registration whether or not any Holder has elected to include
securities in such registration. The Registration Expenses of such withdrawn registration shall be borne by the Company in accordance with Section 2.5 hereof. 
 2.4 Form S-3 Registration. In case the Company shall receive from any Holder or Holders of Registrable Securities a written request or requests that the Company effect a registration on
Form S-3 (or any successor to Form S-3) or any similar short-form registration statement and any related qualification or compliance with respect to all or a part of the Registrable Securities owned by such Holder or Holders, the Company
will: 
 (a) promptly give written notice of the proposed registration, and any related qualification or compliance, to
all other Holders of Registrable Securities; and 
 (b) as soon as practicable, effect such registration and all such
qualifications and compliances as may be so requested and as would permit or facilitate the sale and distribution of all or such portion of such Holder’s or Holders’ Registrable Securities as are specified in such request, together with
all or such portion of the Registrable Securities of any 

  
 7. 

 
other Holder or Holders joining in such request as are specified in a written request given within fifteen (15) days after receipt of such written notice from the Company; provided,
however, that the Company shall not be obligated to effect any such registration, qualification or compliance pursuant to this Section 2.4: 
 (i) if Form S-3 is not available for such offering by the Holders; 

(ii) if the Holders, together with the holders of any other securities of the Company entitled to inclusion in such registration,
propose to sell Registrable Securities and such other securities (if any) at an aggregate price to the public of less than five million dollars ($5,000,000); 
 (iii) if within thirty (30) days of receipt of a written request from any Holder or Holders pursuant to this Section 2.4, the Company gives notice to such Holder or Holders of the
Company’s intention to make a public offering within ninety (90) days, other than pursuant to a Special Registration Statement; 
 (iv) if the Company shall furnish to the Holders a certificate signed by the Chairman of the Board of Directors of the Company stating that in the good faith judgment of the Board of Directors of
the Company, it would be seriously detrimental to the Company and its stockholders for such Form S-3 registration to be effected at such time, in which event the Company shall have the right to defer the filing of the Form S-3 registration
statement for a period of not more than ninety (90) days after receipt of the request of the Holder or Holders under this Section 2.4; provided that such right to delay a request shall be exercised by the Company not more than once
in any twelve (12) month period; or 
 (v) in any particular jurisdiction in which the Company would be required to
qualify to do business or to execute a general consent to service of process in effecting such registration, qualification or compliance. 
 (c) Subject to the foregoing, the Company shall file a Form S-3 registration statement covering the Registrable Securities and other securities so requested to be registered as soon as
practicable after receipt of the requests of the Holders. Registrations effected pursuant to this Section 2.4 shall not be counted as demands for registration or registrations effected pursuant to Section 2.2. 

2.5 Expenses of Registration. Except as specifically provided herein, all Registration Expenses incurred in connection with any
registration, qualification or compliance pursuant to Section 2.2 or any registration under Section 2.3 or Section 2.4 herein shall be borne by the Company. All Selling Expenses incurred in connection with any registrations hereunder,
shall be borne by the holders of the securities so registered pro rata on the basis of the number of shares so registered. The Company shall not, however, be required to pay for expenses of any registration proceeding begun pursuant to
Section 2.2 or 2.4, the request of which has been subsequently withdrawn by the Initiating Holders unless (a) the withdrawal is based upon material adverse information concerning the Company of which the Initiating Holders were not aware
at the time of such request or (b) the Holders of a majority of Registrable Securities agree to forfeit their right to one requested registration pursuant to Section 2.2 or Section 2.4, as

  
 8. 

 
applicable, in which event such right shall be forfeited by all Holders. If the Holders are required to pay the Registration Expenses, such expenses shall be borne by the holders of securities
(including Registrable Securities) requesting such registration in proportion to the number of shares for which registration was requested. If the Company is required to pay the Registration Expenses of a withdrawn offering pursuant to
clause (a) above, then the Holders shall not forfeit their rights pursuant to Section 2.2 or Section 2.4 to a demand registration. 
 2.6 Obligations of the Company. Whenever required to effect the registration of any Registrable Securities, the Company shall, as expeditiously as reasonably possible: 

(a) prepare and file with the SEC a registration statement with respect to such Registrable Securities and use its reasonable best
efforts to cause such registration statement to become effective, and, upon the request of the Holders of a majority of the Registrable Securities registered thereunder, keep such registration statement effective for up to ninety (90) days or,
if earlier, until the Holder or Holders have completed the distribution related thereto; provided, however, that at any time, upon written notice to the participating Holders and for a period not to exceed ninety (90) days thereafter
(the “Suspension Period”), the Company may delay the filing or effectiveness of any registration statement or suspend the use or effectiveness of any registration statement (and the Initiating Holders hereby agree not to
offer or sell any Registrable Securities pursuant to such registration statement during the Suspension Period) if the Company reasonably believes that the Company may, in the absence of such delay or suspension hereunder, be required under state or
federal securities laws to disclose any corporate development the disclosure of which could reasonably be expected to have a material adverse effect upon the Company, its stockholders, a potentially significant transaction or event involving the
Company, or any negotiations, discussions, or proposals directly relating thereto. In the event that the Company shall exercise its right to delay or suspend the filing or effectiveness of a registration hereunder, the applicable time period during
which the registration statement is to remain effective shall be extended by a period of time equal to the duration of the Suspension Period. No more than one (1) such Suspension Period shall occur in any twelve (12) month period. If so
directed by the Company in writing, all Holders registering shares under such registration statement shall use their reasonable best efforts to deliver to the Company (at the Company’s expense) all copies, other than permanent file copies then
in such Holders’ possession, of the prospectus relating to such Registrable Securities current at the time of receipt of such notice. 
 (b) Prepare and file with the SEC such amendments and supplements to such registration statement and the prospectus used in connection with such registration statement as may be necessary to comply
with the provisions of the Securities Act with respect to the disposition of all securities covered by such registration statement for the period set forth in subsection (a) above. 

(c) Furnish to the Holders such number of copies of a prospectus, including a preliminary prospectus, in conformity with the
requirements of the Securities Act, and such other documents as they may reasonably request in order to facilitate the disposition of Registrable Securities owned by them. 

  
 9. 

 (d) Use its reasonable best efforts to register and qualify the securities covered by
such registration statement under such other securities or Blue Sky laws of such jurisdictions as shall be reasonably requested by the Holders; provided that the Company shall not be required in connection therewith or as a condition thereto
to qualify to do business or to file a general consent to service of process in any such states or jurisdictions. 
 (e)
In the event of any underwritten public offering, enter into and perform its obligations under an underwriting agreement, in usual and customary form, with the managing underwriter(s) of such offering. Each Holder participating in such
underwriting shall also enter into and perform its obligations under such an agreement. 
 (f) Notify each Holder of
Registrable Securities covered by such registration statement at any time when a prospectus relating thereto is required to be delivered under the Securities Act of the happening of any event as a result of which the prospectus included in such
registration statement, as then in effect, includes an untrue statement of a material fact or omits to state a material fact required to be stated therein or necessary to make the statements therein not misleading in the light of the circumstances
then existing. The Company will use reasonable efforts to amend or supplement such prospectus in order to cause such prospectus not to include any untrue statement of a material fact or omit to state a material fact required to be stated therein or
necessary to make the statements therein not misleading in the light of the circumstances then existing. 
 (g) Cause all
such Registrable Securities registered pursuant hereunder to be listed on each securities exchange on which similar securities issued by the Company are then listed. 
 (h) Provide a transfer agent and registrar for all Registrable Securities registered pursuant hereunder and a CUSIP number for all such Registrable Securities, in each case not later than the
effective date of such registration. 
 (i) Use its reasonable best efforts to furnish, on the date that such Registrable
Securities are delivered to the underwriters for sale, if such securities are being sold through underwriters, or if such securities are not being sold through underwriters, on the date that the registration statement with respect to such securities
becomes effective, (i) an opinion, dated as of such date, of the counsel representing the Company for the purposes of such registration, in form and substance as is customarily given to underwriters in an underwritten public offering, addressed
to the underwriters, if any, and to the Holders requesting registration of Registrable Securities, and (ii) a letter, dated as of such date, from the independent certified public accountants of the Company, in form and substance as is
customarily given by independent certified public accountants to underwriters in an underwritten public offering addressed to the underwriters. 
 2.7 Termination of Registration Rights. All registration rights granted under this Section 2 shall terminate and be of no further force and effect on the earlier of: (a) the date of the
closing of an Acquisition or Asset Transfer, each as defined in the Company’s Amended and Restated Certificate of Incorporation as in effect as of the date hereof, in which the consideration received by the Company’s stockholders consists
of either cash, securities that are transferable 

  
 10.

 
without restriction or a combination thereof, and, in the case of an Acquisition, in which all Registrable Securities are exchanged for securities of the surviving entity or its parent or
(b) the later of (i) one (1) year after the date of the Initial Offering or (ii) with respect to each Holder, at such time as the (A) Company’s capital stock is publicly traded and (B) such Holder is entitled to
sell all of its shares pursuant to Rule 144 of the Securities Act during any ninety (90) day period. 
 2.8 Delay of
Registration; Furnishing Information. 
 (a) No Holder shall have any right to obtain or seek an injunction
restraining or otherwise delaying any such registration initiated by the Holders as the result of any controversy that might arise with respect to the interpretation or implementation of this Section 2. 

(b) It shall be a condition precedent to the obligations of the Company to take any action pursuant to Section 2.2, 2.3 or
2.4 that the selling Holders shall furnish to the Company such information regarding themselves, the Registrable Securities held by them and the intended method of disposition of such securities as shall be required to effect the registration of
their Registrable Securities. 
 (c) The Company shall have no obligation with respect to any registration requested
pursuant to Section 2.2 or Section 2.4 if, due to the operation of subsection 2.2(b), the number of shares or the anticipated aggregate offering price of the Registrable Securities to be included in the registration does not equal or
exceed the number of shares or the anticipated aggregate offering price required to originally trigger the Company’s obligation to initiate such registration as specified in Section 2.2 or Section 2.4, whichever is applicable.

 2.9 Indemnification. In the event any Registrable Securities are included in a registration statement under
Sections 2.2, 2.3 or 2.4: 
 (a) To the extent permitted by law, the Company will indemnify and hold harmless each
Holder, the partners, members, officers and directors of each Holder, any underwriter (as defined in the Securities Act) for such Holder and each person, if any, who controls such Holder or underwriter within the meaning of the Securities Act or the
Exchange Act, against any losses, claims, damages, or liabilities (joint or several) to which they may become subject under the Securities Act, the Exchange Act or other federal or state law, insofar as such losses, claims, damages or liabilities
(or actions in respect thereof) arise out of or are based upon any of the following statements, omissions or violations (collectively a “Violation”) by the Company: (i) any untrue statement or alleged untrue statement of
a material fact contained in such registration statement or incorporated by reference therein, including any preliminary prospectus or final prospectus contained therein or any amendments or supplements thereto, (ii) the omission or alleged
omission to state therein a material fact required to be stated therein, or necessary to make the statements therein not misleading, or (iii) any violation or alleged violation by the Company of the Securities Act, the Exchange Act, any state
securities law or any rule or regulation promulgated under the Securities Act, the Exchange Act or any state securities law in connection with the offering covered by such registration statement; and the Company will reimburse each such Holder,
partner, member, officer, director, underwriter or controlling person for any legal or other expenses reasonably incurred by them in connection with 

  
 11.

 
investigating or defending any such loss, claim, damage, liability or action; provided however, that the indemnity agreement contained in this Section 2.9(a) shall not apply to
amounts paid in settlement of any such loss, claim, damage, liability or action if such settlement is effected without the consent of the Company, which consent shall not be unreasonably withheld, nor shall the Company be liable in any such case for
any such loss, claim, damage, liability or action to the extent that it arises out of or is based upon a Violation which occurs in reliance upon and in conformity with written information furnished expressly for use in connection with such
registration by such Holder, partner, member, officer, director, underwriter or controlling person of such Holder. 
 (b)
To the extent permitted by law, each Holder will, if Registrable Securities held by such Holder are included in the securities as to which such registration qualifications or compliance is being effected, indemnify and hold harmless the Company,
each of its directors, its officers and each person, if any, who controls the Company within the meaning of the Securities Act, any underwriter and any other Holder selling securities under such registration statement or any of such other
Holder’s partners, directors or officers or any person who controls such Holder, against any losses, claims, damages or liabilities (joint or several) to which the Company or any such director, officer, controlling person, underwriter or other
such Holder, or partner, director, officer or controlling person of such other Holder may become subject under the Securities Act, the Exchange Act or other federal or state law, insofar as such losses, claims, damages or liabilities (or actions in
respect thereto) arise out of or are based upon any of the following statements: (i) any untrue statement or alleged untrue statement of a material fact contained in such registration statement or incorporated by reference therein, including
any preliminary prospectus or final prospectus contained therein or any amendments or supplements thereto, (ii) the omission or alleged omission to state therein a material fact required to be stated therein, or necessary to make the statements
therein not misleading, or (iii) any violation or alleged violation by the Company of the Securities Act (collectively, a “Holder Violation”), in each case to the extent (and only to the extent) that such Holder
Violation occurs in reliance upon and in conformity with written information furnished by such Holder under an instrument duly executed by such Holder and stated to be specifically for use in connection with such registration; and each such Holder
will reimburse any legal or other expenses reasonably incurred by the Company or any such director, officer, controlling person, underwriter or other Holder, or partner, officer, director or controlling person of such other Holder in connection with
investigating or defending any such loss, claim, damage, liability or action if it is judicially determined that there was such a Holder Violation; provided, however, that the indemnity agreement contained in this Section 2.9(b) shall
not apply to amounts paid in settlement of any such loss, claim, damage, liability or action if such settlement is effected without the consent of the Holder, which consent shall not be unreasonably withheld; provided further, that in no
event shall any indemnity under this Section 2.9 exceed the net proceeds from the offering received by such Holder. 

(c) Promptly after receipt by an indemnified party under this Section 2.9 of notice of the commencement of any action
(including any governmental action), such indemnified party will, if a claim in respect thereof is to be made against any indemnifying party under this Section 2.9, deliver to the indemnifying party a written notice of the commencement thereof
and the indemnifying party shall have the right to participate in, and, to the extent the indemnifying party so desires, jointly with any other indemnifying party similarly noticed, to 

  
 12.

 
assume the defense thereof with counsel mutually satisfactory to the parties; provided, however, that an indemnified party shall have the right to retain its own counsel, with the fees and
expenses to be paid by the indemnifying party, if representation of such indemnified party by the counsel retained by the indemnifying party would be inappropriate due to actual or potential differing interests between such indemnified party and any
other party represented by such counsel in such proceeding. The failure to deliver written notice to the indemnifying party within a reasonable time of the commencement of any such action, if materially prejudicial to its ability to defend such
action, shall relieve such indemnifying party of any liability to the indemnified party under this Section 2.9, but the omission so to deliver written notice to the indemnifying party will not relieve it of any liability that it may have to any
indemnified party otherwise than under this Section 2.9. 
 (d) If the indemnification provided for in this
Section 2.9 is held by a court of competent jurisdiction to be unavailable to an indemnified party with respect to any losses, claims, damages or liabilities referred to herein, the indemnifying party, in lieu of indemnifying such indemnified
party thereunder, shall to the extent permitted by applicable law contribute to the amount paid or payable by such indemnified party as a result of such loss, claim, damage or liability in such proportion as is appropriate to reflect the relative
fault of the indemnifying party on the one hand and of the indemnified party on the other in connection with the Violation(s) or Holder Violation(s) that resulted in such loss, claim, damage or liability, as well as any other relevant equitable
considerations. The relative fault of the indemnifying party and of the indemnified party shall be determined by a court of law by reference to, among other things, whether the untrue or alleged untrue statement of a material fact or the omission to
state a material fact relates to information supplied by the indemnifying party or by the indemnified party and the parties’ relative intent, knowledge, access to information and opportunity to correct or prevent such statement or omission;
provided that in no event shall any contribution by a Holder, when combined with any amounts paid by such Holder pursuant to Section 2.9(b), exceed the net proceeds from the offering received by such Holder. 

(e) The obligations of the Company and Holders under this Section 2.9 shall survive completion of any offering of Registrable
Securities in a registration statement and the termination of this Agreement. No indemnifying party, in the defense of any such claim or litigation, shall, except with the consent of each indemnified party, consent to entry of any judgment or enter
into any settlement which does not include as an unconditional term thereof the giving by the claimant or plaintiff to such Indemnified Party of a release from all liability in respect to such claim or litigation. 

2.10 Assignment of Registration Rights. The rights to cause the Company to register Registrable Securities pursuant to this
Section 2 may be assigned by a Holder to a transferee or assignee of Registrable Securities that (a) is a general partner, limited partner, retired partner, member or former member, or affiliate of a Holder, (b) is a Holder’s
family member or trust for the benefit of an individual Holder, or (c) acquires at least twenty-five percent (25%) of the Holder’s Registrable Securities (as adjusted for stock splits and combinations); provided, however, that
all shares of Registrable Securities held by an Affiliate of Holder shall be aggregated for purposes of the calculation in subsection (c); provided further, however, (i) the transferor shall, within ten (10) days after such
transfer, furnish to the Company written notice of the name and address of such transferee or assignee and the securities with respect to which such 

  
 13.

 
registration rights are being assigned and (ii) such transferee shall agree to be subject to all restrictions set forth in this Agreement. 

2.11 Amendment of Registration Rights. Any provision of this Section 2 may be amended and the observance thereof may be
waived (either generally or in a particular instance and either retroactively or prospectively), only with the written consent of the Company and the Holders of at least two-thirds of the Registrable Securities then outstanding. Any amendment or
waiver effected in accordance with this Section 2.11 shall be binding upon each Holder and the Company. By acceptance of any benefits under this Section 2, Holders of Registrable Securities hereby agree to be bound by the provisions
hereunder. 
 2.12 Limitation on Subsequent Registration Rights. Other than as provided in Section 5.11, after the
date of this Agreement, the Company shall not, without the prior written consent of the Holders of at least at least two-thirds of the Registrable Securities then outstanding, enter into any agreement with any holder or prospective holder of any
securities of the Company that would grant such holder registration rights senior to those granted to the Holders hereunder, other than the right to a Special Registration Statement. 

2.13 “Market Stand-Off” Agreement. Each Holder hereby agrees that such Holder shall not sell, transfer, make any short
sale of, grant any option for the purchase of, or enter into any hedging or similar transaction with the same economic effect as a sale of, any Common Stock (or other securities) of the Company held by such Holder (other than those included in the
registration) for a period specified by the representative of the underwriters of Common Stock (or other securities) of the Company not to exceed one hundred eighty (180) days following the effective date of the initial registration statement
of the Company filed under the Securities Act; provided that all officers and directors of the Company and holders of at least five percent (5%) of the Company’s voting securities enter into similar agreements. Notwithstanding the
foregoing, the Company shall use all reasonable efforts to have any early release from the lock-up period contained in the agreement to be apportioned pro rata among all Holders. 

2.14 Agreement to Furnish Information. Each Holder agrees to execute and deliver such other agreements as may be reasonably
requested by the Company or the underwriter that are consistent with the Holder’s obligations under Section 2.13 or that are necessary to give further effect thereto. In addition, if requested by the Company or the representative of the
underwriters of Common Stock (or other securities) of the Company, each Holder shall provide, within ten (10) days of such request, such information as may be required by the Company or such representative in connection with the completion of
any public offering of the Company’s securities pursuant to a registration statement filed under the Securities Act. The obligations described in Section 2.13 and this Section 2.14 shall not apply to a Special Registration Statement.
The Company may impose stop-transfer instructions with respect to the shares of Common Stock (or other securities) subject to the foregoing restriction until the end of said one hundred eighty (180) day period. Each Holder agrees that any
transferee of any shares of Registrable Securities shall be bound by Sections 2.13 and 2.14. The underwriters of the Company’s stock are intended third party beneficiaries of Sections 2.13 and 2.14 and shall have the right, power and
authority to enforce the provisions hereof as though they were a party hereto. 

  
 14.

 2.15 Rule 144 Reporting. With a view to making available to the Holders the benefits
of certain rules and regulations of the SEC which may permit the sale of the Registrable Securities to the public without registration, the Company agrees to use its best efforts to: 

(a) Make and keep public information available, as those terms are understood and defined in SEC Rule 144 or any similar or
analogous rule promulgated under the Securities Act, at all times after the effective date of the first registration filed by the Company for an offering of its securities to the general public; 

(b) File with the SEC, in a timely manner, all reports and other documents required of the Company under the Exchange Act; and

 (c) So long as a Holder owns any Registrable Securities, furnish to such Holder forthwith upon request: a written
statement by the Company as to its compliance with the reporting requirements of said Rule 144 of the Securities Act, and of the Exchange Act (at any time after it has become subject to such reporting requirements); a copy of the most recent annual
or quarterly report of the Company filed with the Commission; and such other reports and documents as a Holder may reasonably request in connection with availing itself of any rule or regulation of the SEC allowing it to sell any such securities
without registration. 
 SECTION 3. COVENANTS OF THE COMPANY. 

3.1 Basic Financial Information and Reporting. 
 (a) The Company will maintain true books and records of account in which full and correct entries will be made of all its business transactions pursuant to a system of accounting established and
administered in accordance with generally accepted accounting principles consistently applied (except as noted therein or as disclosed to the recipients thereof), and will set aside on its books all such proper accruals and reserves as shall be
required under generally accepted accounting principles consistently applied. 
 (b) So long as an Investor (with its
affiliates) shall own not less than two million (2,000,000) shares of Registrable Securities (as adjusted for stock splits and combinations) (a “Major Investor”), as soon as practicable after the end of each fiscal year
of the Company, and in any event within one hundred twenty (120) days thereafter, the Company will furnish such Major Investor a balance sheet of the Company, as at the end of such fiscal year, and a statement of income and a statement of cash
flows of the Company, for such year, all prepared in accordance with generally accepted accounting principles consistently applied (except as noted therein or as disclosed to the recipients thereof) and setting forth in each case in comparative form
the figures for the previous fiscal year, all in reasonable detail. Such financial statements shall be accompanied by a report and opinion thereon by independent public accountants of national standing selected by the Company’s Board of
Directors. For purposes of Section 3.1 and 3.2 only, each of T. Rowe Price Associates, Inc. and Goldman Sachs Investment Partners Master Fund, L.P. shall be deemed a “Major Investor.” Notwithstanding the foregoing, Biogen shall be
deemed a “Major Investor” for purposes of Sections 3.1(b), 3.1(c) and 3.2 only. 
 (c) The Company will furnish
to a Major Investor, to the extent requested by such Major Investor, as soon as practicable after the end of the first, second and third quarterly 

  
 15.

 
accounting periods in each fiscal year of the Company, and in any event within forty-five (45) days thereafter, a balance sheet of the Company as of the end of each such quarterly period,
and a statement of income and a statement of cash flows of the Company for such period and for the current fiscal year to date, prepared in accordance with generally accepted accounting principles consistently applied (except as noted therein or as
disclosed to the recipients thereof), with the exception that no notes need be attached to such statements and year-end audit adjustments may not have been made. 
 (d) To the extent requested by a Major Investor, the Company will furnish each such Major Investor at least fifteen (15) days prior to the beginning of each fiscal year an annual budget
and operating plans for such fiscal year (and as soon as available, any subsequent written revisions thereto). 
 (e) To
the extent requested, the Company agrees to use commercially reasonable efforts to provide financial information reasonably requested by the independent auditor (the “MPI Auditor”) of Millennium Pharmaceuticals, Inc.
(“Millennium”) in order for the MPI Auditor to evaluate any required accounting issues that may arise as a result of Millennium’s purchase of Series A Stock. 

3.2 Inspection Rights. Each Major Investor shall have the right to visit and inspect any of the properties of the Company or any
of its subsidiaries, and to discuss the affairs, finances and accounts of the Company or any of its subsidiaries with its officers, and to review such information as is reasonably requested all at such reasonable times and as often as may be
reasonably requested; provided, however, that the Company shall not be obligated under this Section 3.2 with respect to a competitor of the Company or with respect to information which the Board of Directors determines in good faith is
confidential or attorney-client privileged and should not, therefore, be disclosed. 
 3.3 Confidentiality of Records.
Each Investor agrees to use the same degree of care as such Investor uses to protect its own confidential information to keep confidential any information furnished to such Investor hereof that the Company identifies as being confidential or
proprietary (so long as such information is not in the public domain), except that such Investor may disclose such proprietary or confidential information (i) to any partner, member, subsidiary, parent or Affiliate of such Investor for the
purpose of evaluating its investment in the Company or under obligation of any partnership agreement or limited liability operating agreement, and as long as such partner, member, subsidiary, parent or Affiliate is advised of and agrees or has
agreed to be bound by the confidentiality provisions of this Section 3.3 or comparable restrictions; (ii) at such time as it enters the public domain through no fault of such Investor; (iii) that is communicated to it free of any
obligation of confidentiality; or (iv) that is developed by Investor or its agents independently of and without reference to any confidential information communicated by the Company. 

3.4 Reservation of Common Stock. The Company will at all times reserve and keep available, solely for issuance and delivery upon
the conversion of the Preferred Stock, all Common Stock issuable from time to time upon such conversion. 

  
 16.

 3.5 Stock Vesting. Unless otherwise approved by the Board of Directors, all stock
options and other stock equivalents issued after the date of this Agreement to employees, directors, consultants and other service providers shall be subject to vesting as follows: (a) twenty-five percent (25%) of such stock shall vest at
the end of the first year following the date of issuance and (b) seventy-five percent (75%) of such stock shall vest monthly over the next three (3) years. With respect to any shares of stock purchased by any such person, the
Company’s repurchase option shall provide that upon such person’s termination of employment or service with the Company, with or without cause, the Company or its assignee shall have the option to purchase at cost any unvested shares of
stock held by such person. 
 3.6 Key Man Insurance. Unless otherwise determined by the Board of Directors, the Company
will maintain in full force and effect term life insurance on the life of William Lis naming the Company as beneficiary. 

3.7 Proprietary Information and Inventions Agreement. The Company shall require all employees and consultants to execute and
deliver a Proprietary Information and Inventions Agreement substantially in a form approved by the Company’s counsel. 

3.8 Assignment of Right of First Refusal. In the event the Company elects not to exercise any right of first refusal or right of
first offer the Company may have on a proposed transfer of any of the Company’s outstanding capital stock pursuant to the Company’s charter documents, by contract or otherwise, the Company shall, to the extent it may do so, assign such
right of first refusal or right of first offer to each Major Investor. In the event of such assignment, each Major Investor shall have a right to purchase its pro rata portion of the capital stock proposed to be transferred. Each Major
Investor’s pro rata portion shall be equal to the product obtained by multiplying (i) the aggregate number of shares proposed to be transferred by (ii) a fraction, the numerator of which is the number of shares of Registrable
Securities held by such Major Investor at the time of the proposed transfer and the denominator of which is the total number of shares owned by all Major Investors at the time of such proposed transfer. 

3.9 Directors’ Expenses. The Company shall reimburse directors for reasonable travel expenses incurred by such directors in
connection with their attendance at meetings of the Board of Directors. 
 3.10 Directors’ Liability and
Indemnification. The Company’s Certificate of Incorporation and Bylaws shall provide (a) for elimination of the liability of directors to the maximum extent permitted by law and (b) for indemnification of directors for acts on
behalf of the Company to the maximum extent permitted by law. The Company shall maintain Directors’ and Officers’ Insurance in an amount at least equal to $10,000,000. The Company shall also enter into customary indemnification agreements
with each of its directors within 180 days following the date of this Agreement. 
 3.11 Board Observers. The Company
shall invite a representative of Maxwell (Mauritius) Pte Ltd (“Maxwell”) to attend all meetings of its Board of Directors in a nonvoting observer capacity and, in this respect, shall give such representative copies of all
notices, minutes, consents and other material that it provides to its directors; provided, however, that the Company reserves the right to exclude such representative from access to any material or

  
 17.

 
meeting or portion thereof if the Company believes upon advice of counsel that such exclusion is reasonably necessary to preserve the attorney-client privilege, to protect highly confidential
proprietary information or for other similar reasons. The Company shall invite a representative of Eastern Capital Limited (“Eastern”) to attend all meetings of its Board of Directors in a nonvoting observer capacity and, in
this respect, shall give such representative copies of all notices, minutes, consents and other material that it provides to its directors; provided, however, that the Company reserves the right to exclude such representative from access to any
material or meeting or portion thereof if the Company believes upon advice of counsel that such exclusion is reasonably necessary to preserve the attorney-client privilege, to protect highly confidential proprietary information or for other similar
reasons. 
 3.12 Termination of Covenants. All covenants of the Company contained in Section 3 of this Agreement
(other than the provisions of Section 3.3 and 3.10) shall expire and terminate as to each Investor upon the earlier of (i) the effective date of the registration statement pertaining to the Initial Offering or (ii) the date of the
closing of an Acquisition or Asset Transfer, each as defined in the Company’s Amended and Restated Certificate of Incorporation as in effect as of the date hereof; provided, that the covenants of the Company contained in
Section 3.11 shall expire and terminate (a) as to Maxwell upon the earlier of (x) the effective date of the registration statement pertaining to the Initial Offering or (y) such time as Maxwell ceases to hold any shares of the
Company’s stock, and (b) as to Eastern upon the earlier of (x) the effective date of the registration statement pertaining to the Initial Offering or (y) such time as Eastern ceases to hold any shares of the Company’s stock.

 SECTION 4. RIGHTS OF FIRST REFUSAL. 
 4.1 Subsequent Offerings. Subject to applicable securities laws, each Major Investor shall have a right of first refusal to purchase its pro rata share of all Equity Securities, as defined
below, that the Company may, from time to time, propose to sell and issue after the date of this Agreement, other than the Equity Securities excluded by Section 4.7 hereof. Each Major Investor’s pro rata share is equal to the ratio
of (a) the number of shares of the Company’s Common Stock (including all shares of Common Stock issuable or issued upon conversion of the Shares or upon the exercise of any outstanding warrants or options) which such Major Investor is
deemed to be a holder immediately prior to the issuance of such Equity Securities to (b) the total number of shares of the Company’s outstanding Common Stock (including all shares of Common Stock issued or issuable upon conversion of the
Shares or upon the exercise of any outstanding warrants or options) immediately prior to the issuance of the Equity Securities. The term “Equity Securities” shall mean (i) any Common Stock, Preferred Stock or other
security of the Company, (ii) any security convertible into or exercisable or exchangeable for, with or without consideration, any Common Stock, Preferred Stock or other security (including any option to purchase such a convertible security),
(iii) any security carrying any warrant or right to subscribe to or purchase any Common Stock, Preferred Stock or other security or (iv) any such warrant or right. 
 4.2 Exercise of Rights. If the Company proposes to issue any Equity Securities, it shall give each Major Investor written notice of its intention, describing the Equity Securities, the price and
the terms and conditions upon which the Company proposes to issue the same. Each Major Investor shall have fifteen (15) days from the giving of such notice to agree to purchase its 

  
 18.

 
pro rata share of the Equity Securities for the price and upon the terms and conditions specified in the notice by giving written notice to the Company and stating therein the quantity of
Equity Securities to be purchased. Notwithstanding the foregoing, the Company shall not be required to offer or sell such Equity Securities to any Major Investor who would cause the Company to be in violation of applicable federal securities laws by
virtue of such offer or sale. 
 4.3 Issuance of Equity Securities to Other Persons. If not all of the Major Investors
elect to purchase their pro rata share of the Equity Securities, then the Company shall promptly notify in writing the Major Investors who do so elect and shall offer such Major Investors the right to acquire such unsubscribed shares. The
Major Investors shall have five (5) days after receipt of such notice to notify the Company of its election to purchase all or a portion thereof of the unsubscribed shares. If the Major Investors fail to exercise in full the rights of first
refusal, the Company shall have ninety (90) days thereafter to sell the Equity Securities in respect of which the Major Investor’s rights were not exercised, at a price and upon general terms and conditions not materially more favorable to
the purchasers thereof than specified in the Company’s notice to the Major Investors pursuant to Section 4.2 hereof. If the Company has not sold such Equity Securities within ninety (90) days of the notice provided pursuant to
Section 4.2, the Company shall not thereafter issue or sell any Equity Securities, without first offering such securities to the Major Investors in the manner provided above. 

4.4 Sale Without Notice. In lieu of giving notice to the Major Investors prior to the issuance of Equity Securities as provided in
Section 4.2, the Company may elect to give notice to the Major Investors within thirty (30) days after the issuance of Equity Securities. Such notice shall describe the type, price and terms of the Equity Securities. Each Major Investor
shall have twenty (20) days from the date of receipt of such notice to elect to purchase up to the number of shares that would, if purchased by such Major Investor, maintain such Major Investor’s pro rata share (as set forth in
Section 4.1) of the Company’s equity securities. The closing of such sale shall occur within sixty (60) days of the date of notice to the Major Investors. 
 4.5 Termination and Waiver of Rights of First Refusal. The rights of first refusal established by this Section 4 shall not apply to, and shall terminate upon the earlier of (i) the
effective date of the registration statement pertaining to the Initial Offering or (ii) the date of the closing of an Acquisition or Asset Transfer, each as defined in the Company’s Amended and Restated Certificate of Incorporation as in
effect as of the date hereof. The rights of first refusal established by this Section 4 may be amended, or any provision waived with the written consent of Major Investors holding at least two-thirds of the Registrable Securities held by all
Major Investors, or as permitted by Section 5.6. 
 4.6 Transfer of Rights of First Refusal. The rights of first
refusal of each Major Investor under this Section 4 may be transferred to the same parties, subject to the same restrictions as any transfer of registration rights pursuant to Section 2.10. 

4.7 Excluded Securities. The rights of first refusal established by this Section 4 shall have no application to any of the
following Equity Securities: 
 (a) shares of Common Stock and/or options, warrants or other Common Stock purchase rights
and the Common Stock issued pursuant to such options, warrants or other rights 

  
 19.

 
issued or to be issued after the Original Issue Date (as defined in the Company’s Amended and Restated Certificate of Incorporation as in effect as of the date hereof) to employees, officers
or directors of, or consultants or advisors to the Company or any subsidiary, pursuant to stock purchase or stock option plans or other arrangements that are approved by the Board of Directors; 

(b) stock issued or issuable pursuant to any rights or agreements, options, warrants or convertible securities outstanding as of
the date of this Agreement (including, without limitation, the Purchase Agreements); and stock issued pursuant to any such rights or agreements granted after the date of this Agreement, so long as the rights of first refusal established by this
Section 4 were complied with or were inapplicable pursuant to any provision of this Section 4.7 with respect to the initial sale or grant by the Company of such rights or agreements; 

(c) any Equity Securities issued for consideration other than cash pursuant to a merger, consolidation, acquisition, strategic
alliance or similar business combination approved by the Board of Directors; 
 (d) shares of Common Stock issued in
connection with any stock split, stock dividend, recapitalization or the like by the Company; 
 (e) shares of Common
Stock issued upon conversion of shares of the Company’s Preferred Stock; 
 (f) any Equity Securities issued
pursuant to any equipment loan or leasing arrangement, real property leasing arrangement, or debt financing from a bank or similar financial institution approved by the Board of Directors; 

(g) any Equity Securities that are issued by the Company pursuant to a registration statement filed under the Securities Act;

 (h) any Equity Securities that are issued to third-party service providers in exchange for or as partial consideration
for services rendered to the Company pursuant to agreements approved by the Board of Directors; and 
 (i) any equity
securities issued in connection with strategic transactions involving the Company and other entities, including (i) joint ventures, manufacturing, marketing or distribution arrangements or (ii) technology transfer or development
arrangements; provided that the issuance of shares therein has been approved by the Board of Directors. 
 SECTION 5.
MISCELLANEOUS. 
 5.1 Amendment and Restatement. The Prior Agreement is terminated in its entirety and restated
herein. Such termination and restatement is effective upon execution of this Agreement by the Company and the Prior Investors holding at least two-thirds of the Registrable Securities held by all Prior Investors (as the term is defined in the Prior
Agreement). Upon such execution, all provisions of, rights granted and covenants made in the Prior Agreement are hereby waived, released and terminated in their entirety and shall have no further force or effect,

  
 20.

 
including any notice of or rights under such Prior Agreement. The rights and covenants contained in this Agreement set forth the sole and entire agreement among the Company and the holders of the
Shares on the subject matter hereof and supersede any and all rights granted and covenants made under any prior agreements. 

5.2 Governing Law. This Agreement shall be governed by and construed under the laws of the State of California in all respects as
such laws are applied to agreements among California residents entered into and to be performed entirely within California. The parties agree that any action brought by any party under or in relation to this Agreement, including without limitation
to interpret or enforce any provision of this Agreement, shall be brought in, and each party agrees to and does hereby consent to the jurisdiction and venue of, any state or federal court located in the County of San Mateo or Santa Clara,
California. 
 5.3 Successors and Assigns. Except as otherwise expressly provided herein, the provisions hereof shall
inure to the benefit of, and be binding upon, the parties hereto and their respective successors, assigns, heirs, executors, and administrators and shall inure to the benefit of and be enforceable by each person who shall be a holder of Registrable
Securities from time to time; provided, however, that prior to the receipt by the Company of adequate written notice of the transfer of any Registrable Securities specifying the full name and address of the transferee, the Company may deem
and treat the person listed as the holder of such shares in its records as the absolute owner and holder of such shares for all purposes, including the payment of dividends or any redemption price. 

5.4 Entire Agreement. This Agreement, the Exhibits and Schedules hereto, the Purchase Agreements and the other documents delivered
pursuant thereto constitute the full and entire understanding and agreement between the parties with regard to the subjects hereof and no party shall be liable or bound to any other in any manner by any oral or written representations, warranties,
covenants and agreements except as specifically set forth herein and therein. Each party expressly represents and warrants that it is not relying on any oral or written representations, warranties, covenants or agreements outside of this Agreement.

 5.5 Severability. In the event one or more of the provisions of this Agreement should, for any reason, be held to be
invalid, illegal or unenforceable in any respect, such invalidity, illegality, or unenforceability shall not affect any other provisions of this Agreement, and this Agreement shall be construed as if such invalid, illegal or unenforceable provision
had never been contained herein. 
 5.6 Amendment and Waiver. 

(a) Except as otherwise expressly provided, this Agreement may be amended or modified only upon the written consent of the Company
and the holders of at least two-thirds of the then-outstanding Registrable Securities. 
 (b) Except as otherwise
expressly provided, the obligations of the Company and the rights of the Holders under this Agreement may be waived only with the written consent of the holders of at least two-thirds of the then-outstanding Registrable Securities. 

  
 21.

 (c) Notwithstanding the foregoing, this Agreement may not be amended or modified, nor
may the obligations of the Company or the rights of the Holders under this Agreement be waived, unless each Holder adversely affected thereby in a manner different than the Holders generally has expressly consented in writing to such amendment,
modification or waiver; provided, however, that, notwithstanding anything to the contrary in this Agreement, Maxwell’s rights pursuant to Sections 3.1 and 3.11 hereof may not be amended or waived without Maxwell’s prior written
consent, and Eastern’s rights pursuant to Section 3.11 hereof may not be amended or waived without Eastern’s prior written consent. 
 (d) For the purposes of determining the number of Holders or Investors entitled to vote or exercise any rights hereunder, the Company shall be entitled to rely solely on the list of record holders
of its stock as maintained by or on behalf of the Company. 
 5.7 Delays or Omissions. It is agreed that no delay or
omission to exercise any right, power, or remedy accruing to any party, upon any breach, default or noncompliance by another party under this Agreement shall impair any such right, power, or remedy, nor shall it be construed to be a waiver of any
such breach, default or noncompliance, or any acquiescence therein, or of any similar breach, default or noncompliance thereafter occurring. It is further agreed that any waiver, permit, consent, or approval of any kind or character on any
party’s part of any breach, default or noncompliance under this Agreement or any waiver on such party’s part of any provisions or conditions of this Agreement must be in writing and shall be effective only to the extent specifically set
forth in such writing. All remedies, either under this Agreement, by law, or otherwise afforded to any party, shall be cumulative and not alternative. 
 5.8 Notices. All notices required or permitted hereunder shall be in writing and shall be deemed effectively given: (a) upon personal delivery to the party to be notified, (b) when sent
by confirmed electronic mail or facsimile if sent during normal business hours of the recipient; if not, then on the next business day, (c) five (5) days after having been sent by registered or certified mail, return receipt requested,
postage prepaid, or (d) two (2) days after deposit with a nationally recognized overnight courier, specifying next day delivery, with written verification of receipt. All communications shall be sent to the party to be notified at the
address as set forth on the signature pages hereof or Exhibit A hereto or at such other address or electronic mail address as such party may designate by ten (10) days advance written notice to the other parties hereto. 

5.9 Attorneys’ Fees. In the event that any suit or action is instituted under or in relation to this Agreement, including
without limitation to enforce any provision in this Agreement, the prevailing party in such dispute shall be entitled to recover from the losing party all fees, costs and expenses of enforcing any right of such prevailing party under or with respect
to this Agreement, including without limitation, such reasonable fees and expenses of attorneys and accountants, which shall include, without limitation, all fees, costs and expenses of appeals. 

5.10 Titles and Subtitles. The titles of the sections and subsections of this Agreement are for convenience of reference only and
are not to be considered in construing this Agreement. 
 5.11 Additional Investors. Notwithstanding anything to the
contrary contained herein, if the Company shall issue additional shares of its Preferred Stock pursuant to the Purchase Agreements (including, without limitation, issuing to Biogen shares of Series 1 Stock

  
 22.

 
pursuant to the Series 1 Purchase Agreement), any purchaser of such shares of Preferred Stock may become a party to this Agreement by executing and delivering an additional counterpart signature
page to this Agreement and shall be deemed an “Investor,” a “Holder” and a party hereunder. Notwithstanding anything to the contrary contained herein, if the Company shall issue Equity Securities in
accordance with Section 4.7(c), Section 4.7(f) or Section 4.7(j) of this Agreement, any purchaser of such Equity Securities may become a party to this Agreement by executing and delivering an additional counterpart signature page to
this Agreement and shall be deemed an “Investor,” a “Holder” and a party hereunder. 
 5.12 Counterparts. This Agreement may be executed in any number of counterparts, each of which shall be an original, but all of which together shall constitute one instrument. 

5.13 Aggregation of Stock. All shares of Registrable Securities held or acquired by affiliated entities or persons or entities
under common management or control shall be aggregated together for the purpose of determining the availability of any rights under this Agreement. 
 5.14 Pronouns. All pronouns contained herein, and any variations thereof, shall be deemed to refer to the masculine, feminine or neutral, singular or plural, as the identity of the parties hereto
may require. 
 5.15 Consent and Waiver of Prior Investors. The undersigned Prior Investors constitute Holders of at
least two-thirds of the Registrable Securities outstanding pursuant to the Prior Agreement and, pursuant to Section 5.6 of the Prior Agreement, hereby consent to (i) the grant of registration rights contemplated herein, (ii) the
waiver of the rights of first refusal as set forth in Section 4 of the Prior Agreement with respect to the issuance of shares of Series 1 Stock and Series D Stock pursuant to the Purchase Agreements (including any related over-allotment
rights), and (iii) the waiver of any notice requirements as set forth in the Prior Agreement with respect thereto. 

[SIGNATURE PAGES FOLLOW] 

  
 23.

 IN WITNESS WHEREOF, the parties hereto
have executed this THIRD AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof.

  

			
	COMPANY:
	
	 PORTOLA PHARMACEUTICALS, INC.

		
	Signature:	 	 /s/ Mardi C. Dier

			
	Print Name:	 	Mardi C. Dier
	Title:	 	Chief Financial Officer
		
	Address:	 	 270 East Grand Avenue, Suite 22
 South San Francisco, CA 94080

 [SIGNATURE PAGE TO THIRD
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the parties hereto
have executed this THIRD AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof.

  

			
	INVESTORS:
	
	MAXWELL (MAURITIUS) PTE LTD
		
	By:	 	 /s/ Khoo Shih

	Name:	 	 Khoo Shih

	Title:	 	 Authorized Signatory

  

[SIGNATURE PAGE TO THIRD AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT] 

 
			
	INVESTORS:
	
	EASTERN CAPITAL LIMITED
		
	By:	 	 /s/ Mark VanDevelde

	Name:	 	Mark VanDevelde
	Title:	 	Director

  

[SIGNATURE PAGE TO THIRD AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT] 

 
			
	INVESTORS:
	
	THOMAS W. PHILLIPS AND PEGGY V. PHILLIPS
		
	By:	 	 /s/ Thomas W. Phillips

	Name:	 	Thomas W. Phillips
		
	By:	 	 /s/ Peggy V. Phillips

	Name:	 	Peggy V. Phillips

  

[SIGNATURE PAGE TO THIRD AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT] 

 
			
	INVESTORS:
	
	 THE ROBERT LEE DOUGLAS AND
ELIZABETH A. STRODE REVOCABLE TRUST DATED OCTOBER 6, 1994
 ELIZABETH ASH STRODE AND ROBERT LEE DOUGLAS, JR.,
TRUSTEES

		
	By:	 	 /s/ Robert Lee Douglas, Jr.

	Name:	 	Robert Lee Douglas, Jr
	Title:	 	Trustee

  

[SIGNATURE PAGE TO THIRD AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT] 

 
			
	INVESTORS:
	
	JEAN-JACQUES BIENAIMÉ
		
	By:	 	 /s/ Jean-Jacques Bienaimé

	Name:	 	Jean-Jacques Bienaimé

  

[SIGNATURE PAGE TO THIRD AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT] 

 
			
	INVESTORS:
	
	H. WARD WOLFF
		
	By:	 	 /s/ H. Ward Wolff

	Name:	 	H. Ward Wolff

  

[SIGNATURE PAGE TO THIRD AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT] 

 
			
	INVESTORS:
	
	 THE RENTON FAMILY COMMUNITY PROPERTY
TRUST
 HOLLINGS CHASE RENTON, III AND MARY
LOUISE RENTON, TRUSTORS AND TRUSTEES

		
	By:	 	 /s/ Hollings Chase Renton, III

	Name:	 	Hollings Chase Renton, III

  

[SIGNATURE PAGE TO THIRD AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT] 

 
			
	INVESTORS:
	
	ADVANCED TECHNOLOGY VENTURES VII, L.P.
	By:	 	ATV Associates VII, LLC, its General Partner
		
	By:	 	 /s/ Jean George

	Name:	 	Jean George
	Title:	 	Managing Director
	
	ADVANCED TECHNOLOGY VENTURES VII (B), L.P.
	By:	 	ATV Associates VII, LLC, its General Partner
		
	By:	 	 /s/ Jean George

	Name:	 	Jean George
	Title:	 	Managing Director
	
	ADVANCED TECHNOLOGY VENTURES VII (C), L.P.
	By:	 	ATV Associates VII, LLC, its General Partner
		
	By:	 	 /s/ Jean George

	Name:	 	Jean George
	Title:	 	Managing Director
	
	ATV ENTREPRENEURS VII, L.P.
	By:	 	ATV Associates VII, LLC, its General Partner
		
	By:	 	 /s/ Jean George

	Name:	 	Jean George
	Title:	 	Managing Director

  

[SIGNATURE PAGE TO THIRD AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT] 

 
			
	INVESTORS:
	
	ALTA BIOPHARMA PARTNERS III, L.P.
	By:	 	Alta BioPharma Management III, LLC
		
	BY:	 	 /s/ Farah Champsi

		 	Director
	
	ALTA BIOPHARMA PARTNERS III GMBH & CO. BETEILIGUNGS
KG
	By:	 	Alta BioPharma Management III, LLC
		
	BY:	 	 /s/ Farah Champsi

		 	Director
	
	ALTA EMBARCADERO BIOPHARMA PARTNERS III, LLC
		
	BY:	 	 /s/ Farah Champsi

		 	Director

  

[SIGNATURE PAGE TO THIRD AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT] 

							
		 		 	INVESTORS:
			
		 		 	 SUTTER HILL VENTURES,

A CALIFORNIA LIMITED PARTNERSHIP

				
		 		 	By:	 	 /s/ Jeffrey W. Bird

		 		 	Name:	 	Jeffrey W. Bird
		 		 		 	Managing Director of the General Partner
			
		 		 	YOVEST, L.P
				
		 	

	 	By:	 	 /s/ Robert Yin

		 	 		 	William H. Younger, Jr., Trustee of
		 	 		 	The William H. Younger, Jr. Revocable Trust
		 	 		 	U/A/D 8/5/09,
		 		 		 	General Partner
			
		 	

	 	 G. LEONARD BAKER, JR. AND MARY
ANNE BAKER,
 CO-TRUSTEES OF THE
BAKER REVOCABLE TRUST U/A/D 2/3/03

		 	 	  
 By:
	 	  
 /s/ Robert
Yin

		 	 		 	G. Leonard Baker, Jr., Trustee
			
		 		 	SAUNDERS HOLDINGS, L.P.
				
		 	

	 	By:	 	 /s/ Robert Yin

		 	 		 	G. Leonard Baker, Jr., Trustee of
		 	 		 	The Baker Revocable Trust U/A/D 2/3/03,
		 	 		 	General Partner

  

[SIGNATURE PAGE TO THIRD AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT] 

					
		 	INVESTORS:
		
	

	 	JAMES C. GAITHER, TRUSTEE OF THE GAITHER REVOCABLE
TRUST U/A/D 9/28/2000
	 	  
 By:
	 	  
 /s/ Robert
Yin

	 		 	James C. Gaither, Trustee
		
		 	TALLACK PARTNERS, L.P.
			
	 

	 	By:	 	 /s/ Robert Yin

	 		 	James C. Gaither, Trustee of
	 		 	The Gaither Revocable Trust U/A/D 9/28/2000,
	 		 	General Partner
		
	

	 	 JAMES N. WHITE AND PATRICIA A. O’BRIEN
AS
 TRUSTEES OF THE WHITE FAMILY
TRUST U/A/D 4/3/97

	 	  
 By:
	 	  
 /s/ Robert
Yin

	 		 	James N. White, Trustee
		
		 	 JEFFREY W. BIRD AND CHRISTINA R. BIRD
AS
 TRUSTEES OF JEFFREY W. AND CHRISTINA R.
BIRD
 TRUST AGREEMENT DATED 10/31/00

			
		 	By:	 	 /s/ Jeffrey W. Bird

		 		 	Jeffrey W. Bird, Trustee
		
	 

	 	 MICHAEL L. SPEISER AND MARY
ELIZABETH
 SPEISER, CO TRUSTEES OF SPEISER
TRUST AGREEMENT
 DATED 7/19/06

	 	  
 By:
	 	  
 /s/ Robert
Yin

	 		 	Michael L. Speiser, Trustee

  

[SIGNATURE PAGE TO THIRD AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT] 

 
	
	INVESTORS:
	
	 WELLS FARGO BANK, N.A. FBO
 SHV PROFIT SHARING PLAN
 FBO
SHERRYL W. CASELLA

	
	 /s/ Thomas M. Thurston

	
	 WELLS FARGO BANK, N.A. FBO
 SHV PROFIT SHARING PLAN
 FBO
DAVID L. ANDERSON

	
	 /s/ Thomas M. Thurston

	
	 WELLS FARGO BANK, N.A. FBO
 SHV PROFIT SHARING PLAN
 FBO
TENCH COXE

	
	 /s/ Thomas M. Thurston

	
	 WELLS FARGO BANK, N.A. FBO
 GREGORY P. SANDS ROTH IRA

	
	 /s/ Thomas M. Thurston

	
	 WELLS FARGO BANK, N.A. FBO
 SHV PROFIT SHARING PLAN
 FBO
ANDREW T. SHEEHAN (ROLLOVER)

	
	 /s/ Thomas M. Thurston

  

[SIGNATURE PAGE TO THIRD AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT] 

 
	
	INVESTORS:
	
	 WELLS FARGO BANK, N.A. FBO
 SHV PROFIT SHARING PLAN
 FBO
DAVID E. SWEET

	
	 /s/ Thomas M. Thurston

	
	 WELLS FARGO BANK, N.A. FBO
 SHV PROFIT SHARING PLAN
 FBO
LYNNE B. GRAW

	
	 /s/ Thomas M. Thurston

	
	 WELLS FARGO BANK, N.A.
 FBO SHV PROFIT SHARING PLAN
 FBO
DIANE J. NAAR

	
	 /s/ Thomas M. Thurston

	
	 WELLS FARGO BANK, N.A. FBO
 SHV PROFIT SHARING PLAN
 FBO
YU-YING CHEN

	
	 /s/ Thomas M. Thurston

	
	 WELLS FARGO BANK, N.A. FBO
 SHV PROFIT SHARING PLAN
 FBO
PATRICIA TOM (PRE)

	
	 /s/ Thomas M. Thurston

	
	 WELLS FARGO BANK, N.A. FBO
 SHV PROFIT SHARING PLAN
 FBO
ROBERT YIN

	
	 /s/ Thomas M. Thurston

  

[SIGNATURE PAGE TO THIRD AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT] 

 
			
	INVESTORS:
	
	PROSPECT VENTURE PARTNERS II, L.P.
	By:	 	Prospect Management Co. II, L.L.C., its General Partner
		
	By:	 	 /s/ Russell Hirsch

		 	Russell Hirsch, Managing Member
	
	PROSPECT ASSOCIATES II, L.P.
	By:	 	Prospect Management Co. II, L.L.C., its General Partner
		
	By:	 	 /s/ Russell Hirsch

		 	Russell Hirsch, Managing Member

  

[SIGNATURE PAGE TO THIRD AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT] 

 
			
	INVESTORS:
	
	MPM BIOVENTURES III, L.P.
		
	By:	 	MPM BioVentures III GP, L.P., its General Partner
	By:	 	MPM BioVentures III LLC, its General Partner
		
	By:	 	 /s/ Nicholas Galakatos

	Name:	 	Nicholas Galakatos
	Title:	 	Series A Member
	
	MPM BIOVENTURES III-QP, L.P.
		
	By:	 	MPM BioVentures III GP, L.P., its General Partner
	By:	 	MPM BioVentures III LLC, its General Partner
		
	By:	 	 /s/ Nicholas Galakatos

	Name:	 	Nicholas Galakatos
	Title:	 	Series A Member
	
	MPM BIOVENTURES III GMBH & CO. BETEILIGUNGS KG
		
	By:	 	MPM BioVentures III GP, L.P., in its capacity as the Managing Limited Partner
	By:	 	MPM BioVentures III LLC, its General Partner
		
	By:	 	 /s/ Nicholas Galakatos

	Name:	 	Nicholas Galakatos
	Title:	 	Series A Member

  

[SIGNATURE PAGE TO THIRD AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT] 

 
			
	INVESTORS:
	
	MPM BIOVENTURES III PARALLEL FUND, L.P.
		
	By:	 	MPM BioVentures III GP, L.P., its General Partner
	By:	 	MPM BioVentures III LLC, its General Partner
		
	By:	 	 /s/ Nicholas Galakatos

	Name:	 	Nicholas Galakatos
	Title:	 	Series A Member
	
	MPM ASSET MANAGEMENT INVESTORS 2003 BVIII LLC
		
	By:	 	 /s/ Nicholas Galakatos

	Name:	 	Nicholas Galakatos
	Title:	 	Manager

  

[SIGNATURE PAGE TO THIRD AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT] 

 
			
	INVESTORS:
	
	FRAZIER HEALTHCARE IV, L.P.
	By	 	FHM IV, LP, its general partner
	By	 	FHM IV, LLC, its general partner
		
	By	 	 /s/ James Topper

		 	James Topper, Authorized Representative
	
	FRAZIER AFFILIATES IV, L.P.
	By	 	FHM IV, LP, its general partner
	By	 	FHM IV, LLC, its general partner
		
	By:	 	 /s/ James Topper

		 	James Topper, Authorized Representative

  

[SIGNATURE PAGE TO THIRD AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT] 

 
			
	INVESTORS:
	
	ABINGWORTH BIOVENTURES IV LP
	Acting by its Manager,
	Abingworth Management Limited
		
	Signature:	 	 /s/ James Abell

		
	Print Name:	 	 James Abell

		
	Title:	 	 Director

	
	ABINGWORTH BIOVENTURES IV
	EXECUTIVES LP
	Acting by its Manager,
	Abingworth Management Limited
		
	Signature:	 	 /s/ James Abell

		
	Print Name:	 	 James Abell

		
	Title:	 	 Director

  

[SIGNATURE PAGE TO THIRD AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT] 

 
			
	INVESTORS:
	
	ALLIANCEBERNSTEIN VENTURE FUND I, L.P.
		
	By:	 	AllianceBernstein ESG Venture Management,
		 	L.P., its general partner
		
	By:	 	AllianceBernstein Global Derivatives Corporation, its general partner
		
	By:	 	 /s/ Amy Raskin

	Name:	 	 Amy Raskin

	Title:	 	 SVP

	Date:	 	 11/16/11

  

[SIGNATURE PAGE TO THIRD AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT] 

 
			
	INVESTORS:
	
	BROOKSIDE CAPITAL PARTNERS FUND LP
		
	Signature:	 	 /s/ Matthew McPherson

		
	Print Name:	 	 Matthew McPherson

		
	Title:	 	 Managing Director

  

[SIGNATURE PAGE TO THIRD AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT] 

 
			
	INVESTORS:
	
	BLACKBOARD VENTURES INC.
		
	Signature:	 	 /s/ Terry Woodward

		 	Terry Woodward
		 	Authorized Signatory

  

[SIGNATURE PAGE TO THIRD AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT] 

 
			
	INVESTORS:
	
	BAKER BROS. INVESTMENTS II, L.P.
	By:	 	Baker Bros. Capital, L.P.,
		 	its general partner
	By:	 	Baker Bros. Capital (GP), LLC,
		 	its general partner
		
	By:	 	 /s/ Felix Baker

	Name:	 	Felix Baker, Ph.D.
	Title:	 	Managing Member
	
	667, L.P.
	By:	 	Baker Biotech Capital, L.P.,
		 	its general partner
	By:	 	Baker Biotech Capital (GP), LLC,
		 	its general partner
		
	By:	 	 /s/ Felix Baker

	Name:	 	Felix Baker, Ph.D.
	Title:	 	Managing Member
	
	BAKER BROTHERS LIFE SCIENCES, L.P.
	By:	 	Baker Brothers Life Sciences Capital, L.P.
		 	its general partner
	By:	 	Baker Brothers Life Sciences Capital (GP), LLC,
		 	its general partner
		
	By:	 	 /s/ Felix Baker

	Name:	 	Felix Baker, Ph.D.
	Title:	 	Managing Member
	
	14159, L.P.
	By:	 	14159 Capital, L.P.,
		 	its general partner
	By:	 	14159 Capital (GP), LLC,
		 	its general partner
		
	By:	 	 /s/ Felix Baker

	Name:	 	Felix Baker, Ph.D.
	Title:	 	Managing Member

  

[SIGNATURE PAGE TO THIRD AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT] 

 
			
	INVESTORS:
	
	GOLDMAN SACHS INVESTMENT PARTNERS
	MASTER FUND, L.P.
	
	BY: GOLDMAN SACHS INVESTMENT PARTNERS GP, LLC, ITS GENERAL
PARTNER
		
	BY:	 	 /s/ Michelle Barone

	NAME:	 	 Michelle Barone

	TITLE:	 	 Vice President

  

[SIGNATURE PAGE TO THIRD AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT] 

 
							
	INVESTORS:
	
	BBT FUND, L.P.
		
	By:	 	BBT GENPAR, L.P., its general partner
			
		 	By:	 	BBT-FW, INC., its general partner
				
		 		 	By:	 	 /s/ William O. Reimann

		 		 		 	William O. Reimann, Vice President

  

[SIGNATURE PAGE TO THIRD AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT] 

 
	
	INVESTORS:
	
	PAC-LINK BIOVENTURES I
	
	 /s/ Shan Ko Hsu

	Shan Ko Hsu
	Chairman

  

[SIGNATURE PAGE TO THIRD AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT] 

 
			
	T. ROWE PRICE ASSOCIATES, INC., INVESTMENT
ADVISER FOR
AND ON BEHALF OF T. ROWE PRICE
HEALTH SCIENCES FUND, INC.
		
	Signature:	 	 /s/ Kris H. Jenner

		
	Name:	 	 Kris H. Jenner

		
	Title:	 	 Vice Presidenrt

  

[SIGNATURE PAGE TO THIRD AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT] 

 POWER OF ATTORNEY 

and 

DELEGATION OF POWERS 

KNOW ALL PERSONS BY THESE PRESENTS: 

That the undersigned, Lynne B. Graw, has made, constituted and appointed, and by these presents does make, constitute and appoint,
each of David L. Anderson, G. Leonard Baker, Jr., Jeffrey W. Bird, Tench Coxe, James C. Gaither, Gregory P. Sands, Andrew T. Sheehan, Michael L. Speiser, David E. Sweet, James N. White, Robert Yin, or William H. Younger, Jr. her true and
lawful attorney in fact in her name, place, and stead, whether as an individual, as a trustee of any trust, as a manager or managing director of any limited liability company, or as a general or limited partner in any partnership, to do
any and all acts with respect to any transaction relating to any company (including, but not limited to, corporations, partnerships, trusts, limited liability companies, etc.) (a) presently or formerly in, or becoming part of, the
portfolio of Sutter Hill Ventures, a California Limited Partnership or SHV Special Purpose L.P. or (b) presently or formerly managed by Sutter Hill Management Company, LLC. 

In connection with the foregoing appointments, Lynne B. Graw (the “Trustee”), as grantor and trustee of Steven J. Graw and
Lynne B. Graw, Trustees for The Graw Family Trust (the “Trust”) does, pursuant to California Probate Code § 16052, hereby (i) delegate to each of the above named individuals (each a sophisticated investor and or tax advisor)
with the power to act alone, the full power and authority to make all investment decisions and execute and deliver any and all documents, instruments, instructions, requests, certificates or other documents deemed necessary to carry out such
investment decisions, on behalf of the Trustee, with respect to the trust estate of the Trust and without any further authorization, in all cases as limited by the foregoing power of attorney. 

This power of attorney and delegation of authority shall become effective on January 1, 2011 and shall terminate on
December 31, 2011. 
 Executed on November 22, 2010 at Folsom, California. 

 

			
	By:	 	 /s/ Lynne B. Graw

		 	Lynne B. Graw
		
	By:	 	 /s/ Steven J. Graw

		 	Steven J. Graw

 POWER OF ATTORNEY 

and 

DELEGATION OF POWERS 

KNOW ALL PERSONS BY THESE PRESENTS: 

That the undersigned, Tench Coxe, has made, constituted and appointed, and by these presents does make, constitute and
appoint, each of David L. Anderson, G. Leonard Baker, Jr., Jeffrey W. Bird, James C. Gaither, Gregory P. Sands, Andrew T. Sheehan, Michael L. Speiser, David E. Sweet, James N. White, Robert Yin, or William H. Younger, Jr. his
true and lawful attorney in fact in his name, place, and stead, whether as an individual, as a trustee of any trust, as a manager or managing director of any limited liability company, or as a general or limited
partner in any partnership, to do any and all acts with respect to any transaction relating to any company (including, but not limited to, corporations, partnerships, trusts, limited liability companies, etc.) (a)
presently or formerly in, or becoming part of, the portfolio of Sutter Hill Ventures, a California Limited Partnership or SHV Special Purpose L.P. or (b) presently or formerly managed by Sutter Hill Management
Company, LLC. 
 In connection with the foregoing appointments, Tench Coxe (the “Trustee”), as grantor
and co-trustee of The Coxe Revocable Trust U/A/D 4/23/98 (the “Trust”) does, pursuant to California Probate Code § 16052, hereby (i) delegate to each of the above named individuals (each a sophisticated
investor and or tax advisor) with the power to act alone, the full power and authority to make all investment decisions and execute and deliver any and all documents, instruments, instructions, requests, certificates or other documents deemed
necessary to carry out such investment decisions, on behalf of the Trustee, with respect to the trust estate of the Trust and without any further authorization, in all cases as limited by the foregoing power of attorney. 

This power of attorney and delegation of authority shall become effective on January 1, 2011 and shall terminate on
December 31, 2011. 
 Executed on November 22, 2010 at Palo Alto, California. 

 

			
	By:	 	 /s/ Tench Coxe

		 	Tench Coxe

 POWER OF ATTORNEY 

and 

DELEGATION OF POWERS 

KNOW ALL PERSONS BY THESE PRESENTS: 

That the undersigned, Mark W. Younger has made, constituted and appointed, and by these presents does make, constitute and appoint,
each of David L. Anderson, G. Leonard Baker, Jr., Jeffrey W. Bird, Tench Coxe, James C. Gaither, Robert Yin, Gregory P. Sands, Andrew T. Sheehan, Michael L. Speiser, David E. Sweet, James N. White, or William H. Younger, Jr. his true and lawful
attorney in fact in his name, place, and stead, whether as an individual, as a trustee of any trust, as a manager or managing director of any limited liability company, or as a general or limited partner in any partnership, to do any and all
acts with respect to any transaction relating to any company (including, but not limited to, corporations, partnerships, trusts, limited liability companies, etc.) (a) presently or formerly in, or becoming part of, the portfolio of
Sutter Hill Ventures, a California Limited Partnership or SHV Special Purpose L.P. or (b) presently or formerly managed by Sutter Hill Management Company, LLC. 
 This power of attorney and delegation of authority shall become effective on January 1, 2011 and shall terminate on December 31, 2011. 

 

									
	 Executed on
	 	        November        	 	22 , 2010 at	 	        Atherton        ,	 	California.
		 	(Month)	 	(Day)	 	(City)	 	(State)

  

			
	By:	 	 /s/ Mark W. Younger

		 	Mark W. Younger

 POWER OF ATTORNEY 

and 

DELEGATION OF POWERS 

KNOW ALL PERSONS BY THESE PRESENTS: 

That the undersigned, Lauren L. Younger, has made, constituted and appointed, and by these presents does make, constitute and
appoint, each of David L. Anderson, G. Leonard Baker, Jr., Jeffrey W. Bird, Tench Coxe, James C. Gaither, Gregory P. Sands, Andrew T. Sheehan, Michael L. Speiser, David E. Sweet, James N. White, Robert Yin, or William H. Younger her true and
lawful attorney in fact in her name, place, and stead, whether as an individual, as a trustee of any trust, as a manager or managing director of any limited liability company, or as a general or limited partner in any partnership, to do any and
all acts with respect to any transaction relating to any company (including, but not limited to, corporations, partnerships, trusts, limited liability companies, etc.) (a) presently or formerly in, or becoming part of, the
portfolio of Sutter Hill Ventures, a California Limited Partnership or SHV Special Purpose L.P. or b) presently or formerly managed by Sutter Hill Management Company, LLC. 

This power of attorney and delegation of authority shall become effective on January 1, 2011 and shall terminate on
December 31, 2011. 
  

					
	Executed on	  	        November        	 	 19 , 2010 at Menlo Park, California.
		  	(Month)	 	(Day)

  

			
	By:	 	 /s/ Lauren L. Younger

		 	Lauren L. Younger

 POWER OF ATTORNEY 

and 

DELEGATION OF POWERS 

KNOW ALL PERSONS BY THESE PRESENTS: 

That the undersigned, Kelly L. Younger has made, constituted and appointed, and by these presents does make, constitute and
appoint, each of David L. Anderson, G. Leonard Baker, Jr., Jeffrey W. Bird, Tench Coxe, James C. Gaither, Robert Yin, Gregory P. Sands, Andrew T. Sheehan, Michael L. Speiser, David E. Sweet, James N. White, or William H. Younger, Jr. her
true and lawful attorney in fact in her name, place, and stead, whether as an individual, as a trustee of any trust, as a manager or managing director of any limited liability company, or as a general or limited partner in any partnership,
to do any and all acts with respect to any transaction relating to any company (including, but not limited to, corporations, partnerships, trusts, limited liability companies, etc.) (a) presently or formerly in, or becoming part of,
the portfolio of Sutter Hill Ventures, a California Limited Partnership or SHV Special Purpose L.P. or (b) presently or formerly managed by Sutter Hill Management Company, LLC. 

This power of attorney and delegation of authority shall become effective on January 1, 2011 and shall terminate on
December 31, 2011. 
  

									
	 Executed on
	  	        December        	 	  10 , 2010 at	 	        Brookline        ,	 	Massachusetts.
		  	(Month)	 	(Day)	 	(City)	 	(State)

  

			
	By:	 	 /s/ Kelly L. Younger

		 	Kelly L. Younger

 POWER OF ATTORNEY 

and 

DELEGATION OF POWERS 

KNOW ALL PERSONS BY THESE PRESENTS: 

That the undersigned, Julie A. Younger Aleman has made, constituted and appointed, and by these presents does make, constitute
and appoint, each of David L. Anderson, G. Leonard Baker, Jr., Jeffrey W. Bird, Tench Coxe, James C. Gaither, Robert Yin, Gregory P. Sands, Andrew T. Sheehan, Michael L. Speiser, David E. Sweet, James N. White, or William H. Younger, Jr.
her true and lawful attorney in fact in her name, place, and stead, whether as an individual, as a trustee of any trust, as a manager or managing director of any limited liability company, or as a general or limited partner in any partnership, to do
any and all acts with respect to any transaction relating to any company (including, but not limited to, corporations, partnerships, trusts, limited liability companies, etc.) (a) presently or formerly in, or becoming part of, the
portfolio of Sutter Hill Ventures, a California Limited Partnership or SHV Special Purpose L.P. or (b) presently or formerly managed by Sutter Hill Management Company, LLC. 

This power of attorney and delegation of authority shall become effective on January 1, 2011 and shall terminate on
December 31, 2011. 
  

									
	Executed on	  	        November        	 	  21 , 2010 at	 	        San Francisco        ,	 	California.
		  	(Month)	 	(Day)	 	(City)	 	(State)

  

			
	By:	 	 /s/ Julie Aleman

		 	Julie Younger Aleman

 POWER OF ATTORNEY 

and 

DELEGATION OF POWERS 

KNOW ALL PERSONS BY THESE PRESENTS: 

That the undersigned, William H. Younger, Jr., has made, constituted and appointed, and by these presents does make,
constitute and appoint, each of David L. Anderson, G. Leonard Baker, Jr., Jeffrey W. Bird, Tench Coxe, James C. Gaither, Gregory P. Sands, Andrew T. Sheehan, Michael L. Speiser, David E. Sweet, James N. White or Robert Yin his true and lawful
attorney in fact in his name, place, and stead, whether as an individual, as a trustee of any trust, as a manager or managing director of any limited liability company, or as a general or limited partner in any partnership, to do any and
all acts with respect to any transaction relating to any company (including, but not limited to, corporations, partnerships, trusts, limited liability companies, etc.) (a) presently or formerly in, or becoming part of, the portfolio of Sutter
Hill Ventures, a California Limited Partnership or SHV Special Purpose L.P. or (b) presently or formerly managed by Sutter Hill Management Company, LLC. 
 In connection with the foregoing appointments, William H. Younger, Jr. (the “Trustee”), as grantor and trustee of The Younger Living Trust U/A/D 1/20/95 (“Trust #1”)
and the William H. Younger, Jr. Revocable Trust U/A/D 8/5/2009 (“Trust #2”) does, pursuant to California Probate Code § 16052, hereby (i) delegates to each of the above named individuals (each a sophisticated
investor and or tax advisor) with the power to act alone, the full power and authority to make all investment decisions and execute and deliver any and all documents, instruments, instructions, requests, certificates or other documents deemed
necessary to carry out such investment decisions, on behalf of the Trustee, with respect to the trust estate of Trust #1 and/or Trust #2 and without any further authorization, in all cases as limited by the foregoing power of attorney. 

This power of attorney and delegation of authority shall become effective on January 1, 2011 and shall terminate on
December 31, 2011. 
 Executed on November 22, 2010 at Palo Alto, California. 

 

			
	By:	 	 /s/ William H. Younger, Jr.

		 	William H. Younger, Jr.

 POWER OF ATTORNEY 

and 

DELEGATION OF POWERS 

KNOW ALL PERSONS BY THESE PRESENTS: 

That the undersigned, G. Leonard Baker, Jr., has made, constituted and appointed, and by these presents does make, constitute and
appoint, each of David L. Anderson, Jeffrey W. Bird, Tench Coxe, James C. Gaither, Gregory P. Sands, Andrew T. Sheehan, Michael L. Speiser, David E. Sweet, James N. White, Robert Yin, or William H. Younger, Jr. his true and lawful attorney in
fact in his name, place, and stead, whether as an individual, as a trustee of any trust, as a manager or managing director of any limited liability company, or as a general or limited partner in any partnership, to do any and all acts with
respect to any transaction relating to any company (including, but not limited to, corporations, partnerships, trusts, limited liability companies, etc.) (a) presently or formerly in, or becoming part of, the portfolio of Sutter Hill Ventures,
a California Limited Partnership or SHV Special Purpose L.P. or (b) presently or formerly managed by Sutter Hill Management Company, LLC. 
 In connection with the foregoing appointments, G. Leonard Baker, Jr. (the “Trustee”), as grantor and trustee of The Baker Revocable Trust U/A/D 2/3/03 (the “Trust”) does,
pursuant to California Probate Code § 16052, hereby (i) delegate to each of the above named individuals (each a sophisticated investor and or tax advisor) with the power to act alone, the full power and authority to make all
investment decisions and execute and deliver any and all documents, instruments, instructions, requests, certificates or other documents deemed necessary to carry out such investment decisions, on behalf of the Trustee, with respect to the trust
estate of the Trust and without any further authorization, in all cases as limited by the foregoing power of attorney. 

This power of attorney and delegation of authority shall become effective on January 1, 2011 and shall terminate on
December 31, 2011. 
 Executed on November 22, 2010 at Palo Alto, California. 

 

			
	By:	 	 /s/ G. Leonard Baker, Jr.

		 	G. Leonard Baker, Jr.

 POWER OF ATTORNEY 

and 

DELEGATION OF POWERS 

KNOW ALL PERSONS BY THESE PRESENTS: 

That the undersigned, James C. Gaither, has made, constituted and appointed, and by these presents does make, constitute and
appoint, each of David L. Anderson, G. Leonard Baker, Jr., Jeffrey W. Bird, Tench Coxe, Gregory P. Sands, Andrew T. Sheehan, Michael L. Speiser, David E. Sweet, James N. White, or Robert Yin his true and lawful attorney in fact in his name, place,
and stead, whether as an individual, as a trustee of any trust, as a manager or managing director of any limited liability company, or as a general or limited partner in any partnership, to do any and all acts with respect to any transaction
relating to any company (including, but not limited to, corporations, partnerships, trusts, limited liability companies, etc.) (a) presently or formerly in, or becoming part of, the portfolio of Sutter Hill Ventures, a California Limited
Partnership or SHV Special Purpose L.P. or (b) presently or formerly managed by Sutter Hill Management Company, LLC. 
 In
connection with the foregoing appointments, James C. Gaither (the “Trustee”), as grantor and trustee of The Gaither Revocable Trust u/a/d September 28, 2000 (the “Trust”) does, pursuant to California Probate Code
§16052, hereby (i) delegate to each of the above named individuals (each a sophisticated investor and or tax advisor) with the power to act alone, the full power and authority to make all investment decisions and execute and deliver
any and all documents, instruments, instructions, requests, certificates or other documents deemed necessary to carry out such investment decisions, on behalf of the Trustee, with respect to the trust estate of the Trust and without any further
authorization, in all cases as limited by the foregoing power of attorney. 
 This power of attorney and delegation of authority
shall become effective on January 1, 2011 and shall terminate on December 31, 2011. 
 Executed on November 22,
2010 at Palo Alto, California. 
  

			
	By:	 	 /s/ James C. Gaither

		 	James C. Gaither

 POWER OF ATTORNEY 

and 

DELEGATION OF POWERS 

KNOW ALL PERSONS BY THESE PRESENTS: 

That the undersigned, James N. White, has made, constituted and appointed, and by these presents does make, constitute and
appoint, each of David L. Anderson, G. Leonard Baker, Jr., Jeffrey W. Bird, Tench Coxe, James C. Gaither, Gregory P. Sands, Andrew T. Sheehan, Michael L. Speiser, David E. Sweet, Robert Yin, or William H. Younger, Jr. his true and lawful attorney in
fact in his name, place, and stead, whether as an individual, as a trustee of any trust, as a manager or managing director of any limited liability company, or as a general or limited partner in any partnership, to do any and all acts with
respect to any transaction relating to any company (including, but not limited to, corporations, partnerships, trusts, limited liability companies, etc.) (a) presently or formerly in, or becoming part of, the portfolio of Sutter Hill Ventures,
a California Limited Partnership or SHV Special Purpose L.P. or (b) presently or formerly managed by Sutter Hill Management Company, LLC. 
 In connection with the foregoing appointments, James N. White (the “Trustee”), as grantor and co-trustee of The White Family Trust U/A/D 4/3/97 (the “Trust”) does, pursuant
to California Probate Code § 16052, hereby (i) delegate to each of the above named individuals (each a sophisticated investor and or tax advisor) with the power to act alone, the full power and authority to make all investment
decisions and execute and deliver any and all documents, instruments, instructions, requests, certificates or other documents deemed necessary to carry out such investment decisions, on behalf of the Trustee, with respect to the trust estate of the
Trust and without any further authorization, in all cases as limited by the foregoing power of attorney. 
 This power of
attorney and delegation of authority shall become effective on January 1, 2011 and shall terminate on December 31, 2011. 
 Executed on November 22, 2010 at Palo Alto, California. 
  

			
	By:	 	 /s/ James N. White

		 	James N. White

 POWER OF ATTORNEY 

and 

DELEGATION OF POWERS 

KNOW ALL PERSONS BY THESE PRESENTS: 

That the undersigned, Michael L. Speiser, has made, constituted and appointed, and by these presents does make, constitute and
appoint, each of David L. Anderson, G. Leonard Baker, Jr., Jeffrey W. Bird, Tench Coxe, James C. Gaither, Gregory P. Sands, Andrew T. Sheehan, David E. Sweet, James N. White, Robert Yin, or William H. Younger, Jr. his true and lawful attorney
in fact in his name, place, and stead, whether as an individual, as a trustee of any trust, as a manager or managing director of any limited liability company, or as a general or limited partner in any partnership, to do any and all acts
with respect to any transaction relating to any company (including, but not limited to, corporations, partnerships, trusts, limited liability companies, etc.) (a) presently or formerly in, or becoming part of, the portfolio of Sutter Hill
Ventures, a California Limited Partnership or SHV Special Purpose L.P. or (b) presently or formerly managed by Sutter Hill Management Company, LLC. 
 In connection with the foregoing appointments, Michael L. Speiser (the “Trustee”), as grantor and trustee of Speiser Trust Agreement Dated July 19, 2006, Michael L. Speiser and Mary
Elizabeth Speiser, Trustees (the “Trust”) does, pursuant to California Probate Code § 16052, hereby (i) delegate to each of the above named individuals (each a sophisticated investor and or tax advisor) with the power to
act alone, the full power and authority to make all investment decisions and execute and deliver any and all documents, instruments, instructions, requests, certificates or other documents deemed necessary to carry out such investment
decisions, on behalf of the Trustee, with respect to the trust estate of the Trust and without any further authorization, in all cases as limited by the foregoing power of attorney. 

This power of attorney and delegation of authority shall become effective on January 1, 2011, and shall terminate on
December 31, 2011. 
 Executed on November 22, 2010 at Palo Alto, California. 

 

			
	By:	 	 /s/ Michael L. Speiser

		 	Michael L. Speiser

 POWER OF ATTORNEY 

and 

DELEGATION OF POWERS 

KNOW ALL PERSONS BY THESE PRESENTS: 

That the undersigned, David L. Anderson, has made, constituted and appointed, and by these presents does make, constitute and
appoint, each of G. Leonard Baker, Jr., Jeffrey W. Bird, Tench Coxe, James C. Gaither, Gregory P. Sands, Andrew T. Sheehan, Michael L. Speiser, David E. Sweet, James N. White, Robert Yin, or William H. Younger, Jr. his true and lawful attorney
in fact in his name, place, and stead, whether as an individual, as a trustee of any trust, as a manager or managing director of any limited liability company, or as a general or limited partner in any partnership, to do any and all acts
with respect to any transaction relating to any company (including, but not limited to, corporations, partnerships, trusts, limited liability companies, etc.) (a) presently or formerly in, or becoming part of, the portfolio of Sutter Hill
Ventures, a California Limited Partnership or SHV Special Purpose L.P. or (b) presently or formerly managed by Sutter Hill Management Company, LLC. 
 In connection with the foregoing appointments, David L. Anderson (the “Trustee”), as grantor and trustee of The Anderson Living Trust U/A/D 1/22/98 (the “Trust”) does, pursuant
to California Probate Code § 16052, hereby (i) delegate to each of the above named individuals (each a sophisticated investor and or tax advisor) with the power to act alone, the full power and authority to make all investment
decisions and execute and deliver any and all documents, instruments, instructions, requests, certificates or other documents deemed necessary to carry out such investment decisions, on behalf of the Trustee, with respect to the trust estate of the
Trust and without any further authorization, in all cases as limited by the foregoing power of attorney. 
 This power of
attorney and delegation of authority shall become effective on January 1, 2011 and shall terminate on December 31, 2011. 
 Executed on November 22, 2010 at Palo Alto, California. 
  

			
	By:	 	 /s/ David L. Anderson

		 	David L. Anderson

 POWER OF ATTORNEY 

and 

DELEGATION OF POWERS 

KNOW ALL PERSONS BY THESE PRESENTS: 

That the undersigned, Gregory P. Sands, has made, constituted and appointed, and by these presents does make, constitute and
appoint, each of David L. Anderson, G. Leonard Baker, Jr., Jeffrey W. Bird, Tench Coxe, James C. Gaither, Andrew T. Sheehan, Michael L. Speiser, David E. Sweet, James N. White, Robert Yin, or William H. Younger, Jr. his true and lawful attorney in
fact in his name, place, and stead, whether as an individual, as a trustee of any trust, as a manager or managing director of any limited liability company, or as a general or limited partner in any partnership, to do any and all acts with
respect to any transaction relating to any company (including, but not limited to, corporations, partnerships, trusts, limited liability companies, etc.) (a) presently or formerly in, or becoming part of, the portfolio of Sutter Hill Ventures,
a California Limited Partnership or SHV Special Purpose L.P. or (b) presently or formerly managed by Sutter Hill Management Company, LLC. 
 In connection with the foregoing appointments, Gregory P. Sands (the “Trustee”), as grantor and co-trustee of Gregory P. and Sarah J.D. Sands Trust Agreement Dated 2/24/99
(the “Trust”) does, pursuant to California Probate Code § 16052, hereby (i) delegate to each of the above named individuals (each a sophisticated investor and or tax advisor) with the power to act alone, the full power
and authority to make all investment decisions and execute and deliver any and all documents, instruments, instructions, requests, certificates or other documents deemed necessary to carry out such investment decisions, on behalf of the
Trustee, with respect to the trust estate of the Trust and without any further authorization, in all cases as limited by the foregoing power of attorney. 
 This power of attorney and delegation of authority shall become effective on January 1, 2011 and shall terminate on December 31, 2011. 

Executed on November 22, 2010 at Palo Alto, California. 

 

			
	By:	 	 /s/ Gregory P. Sands

		 	Gregory P. Sands

 POWER OF ATTORNEY 

and 

DELEGATION OF POWERS 

KNOW ALL PERSONS BY THESE PRESENTS: 

That the undersigned, Ronald D. Bernal, has made, constituted and appointed, and by these presents does make, constitute and
appoint, each of David L. Anderson, G. Leonard Baker, Jr., Jeffrey W. Bird, Tench Coxe, James C. Gaither, Robert Yin, Gregory P. Sands, Andrew T. Sheehan, Michael L. Speiser, David E. Sweet, James N. White or William H. Younger, Jr. his
true and lawful attorney in fact in his name, place, and stead, whether as an individual, as a trustee of any trust, as a manager or managing director of any limited liability company, or as a general or limited partner in any partnership,
to do any and all acts with respect to any transaction relating to any company (including, but not limited to, corporations, partnerships, trusts, limited liability companies, etc.) (a) presently or formerly in, or becoming part of,
the portfolio of Sutter Hill Ventures, a California Limited Partnership or SHV Special Purpose L.P. or (b) presently or formerly managed by Sutter Hill Management Company, LLC. 

In connection with the foregoing appointments, Ronald D. Bernal (the “Trustee”), as grantor and co-trustee of Bernal Family
Trust U/D/T 11/3/95 (the “Trust”) does, pursuant to California Probate Code § 16052, hereby (i) delegates to each of the above named individuals (each a sophisticated investor and or tax advisor) with the power to act alone,
the full power and authority to make all investment decisions and execute and deliver any and all documents, instruments, instructions, requests, certificates or other documents deemed necessary to carry out such investment decisions, on behalf of
the Trustee, with respect to the trust estate of the Trust and without any further authorization, in all cases as limited by the foregoing power of attorney. 
 This power of attorney and delegation of authority shall become effective on January 1, 2011 and shall terminate on December 31, 2011. 

Executed on November 20 , 2010 at Niwot, Colorado. 

 

			
	By:	 	 /s/ Ronald D. Bernal

		 	Ronald D. Bernal

 POWER OF ATTORNEY 

and 

DELEGATION OF POWERS 

KNOW ALL PERSONS BY THESE PRESENTS: 

That the undersigned, Diane J. Naar, has made, constituted and appointed, and by these presents does make, constitute and appoint,
each of David L. Anderson, G. Leonard Baker, Jr., Jeffrey W. Bird, Tench Coxe, James C. Gaither, Gregory P. Sands, Andrew T. Sheehan, Michael L. Speiser, David E. Sweet, James N. White, Robert Yin, or William H. Younger, Jr. her true and lawful
attorney in fact in her name, place, and stead, whether as an individual, as a trustee of any trust, as a manager or managing director of any limited liability company, or as a general or limited partner in any partnership, to do any and all
acts with respect to any transaction relating to any company (including, but not limited to, corporations, partnerships, trusts, limited liability companies, etc.) (a) presently or formerly in, or becoming part of, the portfolio of Sutter
Hill Ventures, a California Limited Partnership or SHV Special Purpose L.P. or (b) presently or formerly managed by Sutter Hill Management Company, LLC. 
 In connection with the foregoing appointments, Diane J. Naar (the “Trustee”), as grantor and co-trustee of Naar Family Trust U/A/D 12/22/94 (the “Trust”) does, pursuant to
California Probate Code § 16052, hereby (i) delegate to each of the above named individuals (each a sophisticated investor and or tax advisor) with the power to act alone, the full power and authority to make all investment decisions
and execute and deliver any and all documents, instruments, instructions, requests, certificates or other documents deemed necessary to carry out such investment decisions, on behalf of the Trustee, with respect to the trust estate of the Trust
and without any further authorization, in all cases as limited by the foregoing power of attorney. 
 This power of
attorney and delegation of authority shall become effective on January 1, 2011 and shall terminate on December 31, 2011. 
 Executed on November 29, 2010 at Palo Alto, California. 
  

			
	By:	 	 /s/ Diane J. Naar

		 	Diane J. Naar

 POWER OF ATTORNEY 

and 

DELEGATION OF POWERS 

KNOW ALL PERSONS BY THESE PRESENTS: 

That the undersigned, Andrew T. Sheehan, has made, constituted and appointed, and by these presents does make, constitute and
appoint, each of David L. Anderson, G. Leonard Baker, Jr., Jeffrey W. Bird, Tench Coxe, James C. Gaither, Gregory P. Sands, Michael L. Speiser, David E. Sweet, James N. White, Robert Yin, or William H. Younger, Jr. his true and lawful attorney in
fact in his name, place, and stead, whether as an individual, as a trustee of any trust, as a manager or managing director of any limited liability company, or as a general or limited partner in any partnership, to do any and all acts with respect
to any transaction relating to any company (including, but not limited to, corporations, partnerships, trusts, limited liability companies, etc.) (a) presently or formerly in, or becoming part of, the portfolio of Sutter Hill Ventures, a
California Limited Partnership or SHY Special Purpose L.P. or (b) presently or formerly managed by Sutter Hill Management Company, LLC. 
 In connection with the foregoing appointments, Andrew T. Sheehan (the “Trustee”), as grantor and co-trustee of Andrew T. Sheehan and Nicole J. Sheehan as Trustees of Sheehan 2003 Trust
(the “Trust”) does, pursuant to California Probate Code § 16052, hereby (i) delegate to each of the above named individuals (each a sophisticated investor and or tax advisor) with the power to act alone, the full power
and authority to make all investment decisions and execute and deliver any and all documents, instruments, instructions, requests, certificates or other documents deemed necessary to carry out such investment decisions, on behalf of the
Trustee, with respect to the trust estate of the Trust and without any further authorization, in all cases as limited by the foregoing power of attorney. 
 This power of attorney and delegation of authority shall become effective on January 1, 2011 and shall terminate on December 31, 2011. 

Executed on November 22, 2010 at Palo Alto, California. 

 

			
	By:	 	 /s/ Andrew T. Sheehan

		 	Andrew T. Sheehan

 POWER OF ATTORNEY 

and 

DELEGATION OF POWERS 

KNOW ALL PERSONS BY THESE PRESENTS: 

That the undersigned, David E. Sweet, has made, constituted and appointed, and by these presents does make, constitute and appoint,
each of David L. Anderson, G. Leonard Baker, Jr., Jeffrey W. Bird, Tench Coxe, James C. Gaither, Gregory P. Sands, Andrew T. Sheehan, Michael L. Speiser, James N. White, Robert Yin, or William H. Younger, Jr. his true and lawful
attorney in fact in his name, place, and stead, whether as an individual, as a trustee of any trust, as a manager or managing director of any limited liability company, or as a general or limited partner in any partnership, to do any and all
acts with respect to any transaction 1 elating to any company (including, but not limited to, corporations, partnerships, trusts, limited I: ability companies, etc.) (a) presently or formerly in, or becoming part of, the portfolio of Sutter
Hill Ventures, a California Limited Partnership or SHV Special Purpose L.P. or (b) presently or formerly managed by Sutter Hill Management Company, LLC. 
 In connection with the foregoing appointments, David E. Sweet (the “Trustee”), as grantor and co-trustee of The David and Robin Sweet Living Trust Dated 7/6/04 (the
“Trust”) does, pursuant to California Probate Code §16052, hereby (i) delegate to each of the above named individuals (each a sophisticated investor and or tax advisor) with the power to act alone, the full power and
authority to make all investment decisions and execute and deliver any and all documents, instruments, instructions, requests, certificates or other documents deemed necessary to carry out such investment decisions, on behalf of the Trustee, with
respect to the trust estate of the Trust and without any further authorization, in all cases as limited by the foregoing power of attorney. 
 This power of attorney and delegation of authority shall become effective on January 1, 2011 and shall terminate on December 31, 2011. 

Executed on November 22, 2010 at Palo Alto, California. 

 

			
	By:	 	 /s/ David E. Sweet

		 	Davie E. Sweet

 POWER OF ATTORNEY 

and 

DELEGATION OF POWERS 

KNOW ALL PERSONS BY THESE PRESENTS: 

That the undersigned, Patricia Tom, has made, constituted and appointed, and by these presents does make, constitute and appoint,
each of David L. Anderson, G. Leonard Baker, Jr., Jeffrey W. Bird, Tench Coxe, James C. Gaither, Robert Yin, Gregory P. Sands, Andrew T. Sheehan, David E. Sweet, James N. White, or William H. Younger, Jr. her true and lawful attorney in fact in
her name, place, and stead, whether as an individual, as a trustee of any trust, as a manager or managing director of any limited liability company, or as a general or limited partner in any partnership, to do any and all acts with respect to
any transaction relating to any company (including, but not limited to, corporations, partnerships, trusts, limited liability companies, etc.) (a) presently or formerly in, or becoming part of, the portfolio of Sutter Hill Ventures, a
California Limited Partnership or SHV Special Purpose L.P. or (b) presently or formerly managed by Sutter Hill Management Company, LLC. 
 This power of attorney and delegation of authority shall become effective on January 1, 2011 and shall terminate on December 31, 2011. 

Executed on November 22, 2010 at Palo Alto, California. 

 

			
	By:	 	 /s/ Patricia Tom

		 	Patricia Tom

 EXHIBIT A 

INVESTORS 
  

			
	 MAXWELL (MAURITIUS) PTD LTD

Les Cascades
 Edith Cavell Street

Port Louis
 Mauritius

Attn: Director
  
 With a copy to:
  
 c/o 60B
Orchard Road
 #06-18 Tower 2
 The
Atrium@Orchard
 Singapore 238891
  

EASTERN CAPITAL LIMITED
 PO Box 31363
 Suite 3211, 2nd Floor
 45 Market Street
 Camana Bay, KY1-1206
 Grand Cayman
 Cayman Islands
 Attn: Mark VanDevelde
  

THOMAS W. PHILLIPS AND PEGGY V. PHILLIPS

8061 Lakemont Dr NE
 Seattle,
WA 98115
  
 THE ROBERT
LEE DOUGLAS AND ELIZABETH A. STRODE REVOCABLE TRUST DATED OCTOBER 6, 1994

605 Woodmont Ave
 Berkeley, CA 94708

Attn: Robert Lee douglas, Jr.
  

JEAN-JACQUES BIENAIMÉ
 2510 Skyfarm Drive
 Hillsborough, CA 94010

 
 H. WARD WOLFF

200 North Almenar Drive
 Glenbrae, CA
94904
	  	 THE RENTON FAMILY COMMUNITY PROPERTY
TRUST
 39 Avenida Las Palmas
 Rancho Mirage, CA 92270
 Attn: Hollings Chase Renton, III

 
 BIOGEN IDEC MA INC.

14 Cambridge Center
 Cambridge, Massachusetts
02142
  
 SUTTER HILL
VENTURES, A CALIFORNIA LIMITED PARTNERSHIP
 755 Page Mill Road,
Suite A-200
 Palo Alto, CA 94306
 Attn:
Jeff Bird
  
 ANVEST, L.P.

Attn: David L. Anderson, General Partner
 755
Page Mill Road, Suite A-200
 Palo Alto, CA 94306
  

G. LEONARD BAKER JR. AND MARY ANNE BAKER,
CO-TRUSTEES OF THE BAKER REVOCABLE TRUST U/A/D 2/3/03
 755 Page Mill Road, Suite A-200
 Palo Alto, CA 94306

 
 SAUNDERS HOLDINGS, L.P.

Attn: G. Leonard Baker, General Partner
 755 Page
Mill Road, Suite A-200
 Palo Alto, CA 94306
  

WILLIAM H. YOUNGER, JR., REVOCABLE TRUST U/A/D 8/5/2009

755 Page Mill Road, Suite A-200
 Palo Alto, CA
94306
  
 TENCH COXE AND
SIMONE OTUS COXE, CO-TRUSTEES OF THE COXE REVOCABLE TRUST U/A/D 4/23/98

755 Page Mill Road, Suite A-200
 Palo Alto, CA
94306

			
	 JAMES C. GAITHER
 755 Page Mill Road, Suite A-200
 Palo Alto, CA 94306

 
 GREGORY P. SANDS AND
SARAH J.D. SANDS AS TRUSTEES OF GREGORY P. SANDS AND SARAH J.D. SANDS TRUST
AGREEMENT DATED 2/24/99
 755 Page Mill Road, Suite A-200

Palo Alto, CA 94306
  
 JAMES N. WHITE AND PATRICIA A. O’BRIEN AS TRUSTEES OF THE
WHITE FAMILY TRUST U/A/D 4/3/97
 755 Page Mill Road, Suite A-200

Palo Alto, CA 94306
  
 JEFFREY W. BIRD AND CHRISTINA R. BIRD AS TRUSTEES OF JEFFREY W.
BIRD AND CHRISTINA R. BIRD TRUST AGREEMENT DATED 10/31/00
 755 Page Mill Road, Suite A-200
 Palo Alto, CA 94306

 
 RONALD D. BERNAL AND
PAMELA M. BERNAL AS TRUSTEES OF THE BERNAL FAMILY TRUST U/D/T 11/3/1995

755 Page Mill Road, Suite A-200
 Palo Alto, CA
94306
  
 WELLS FARGO BANK,
N.A. FBO SHV PROFIT SHARING PLAN FBO SHERRYL W. HOSSACK
 Attn:
Thomas M. Thurston
 600 California Street 12th Floor
 San Francisco, CA 94108
  

WELLS FARGO BANK, TRUSTEE SHV PROFIT SHARING
PLAN FBO DAVID E. SWEET (ROLLOVER)
 Attn: Thomas M. Thurston

600 California Street 12th Floor
 San Francisco,
CA 94108
	 	 WELLS FARGO BANK, N.A. FBO SHV PROFIT SHARING
PLAN FBO LYNNE B. GRAW
 Attn: Thomas M. Thurston

600 California Street 12th Floor
 San Francisco,
CA 94108
  
 WELLS FARGO
BANK, TRUSTEE PROFIT SHARING PLAN FBO PATRICIA TOM
 Attn: Thomas M. Thurston
 600 California Street 12th Floor

San Francisco, CA 94108
  
 WELLS FARGO BANK, N.A. FBO
 SHV
PROFIT SHARING PLAN FBO PATRICIA TOM (PRE)
 Attn:
Thomas M. Thurston
 600 California Street 12th Floor
 San Francisco, CA 94108
  

WELLS FARGO BANK, N.A. FBO SHV PROFIT SHARING PLAN FBO
ROBERT YIN
 Attn: Thomas M. Thurston
 600 California Street 12th Floor
 San Francisco, CA 94108

 
 WELLS FARGO BANK, FBO SHV
PROFIT SHARING PLAN FBO DAVID L. ANDERSON
 Attn: Thomas M.
Thurston
 600 California Street 12th Floor
 San Francisco, CA 94108
  

PROSPECT VENTURE PARTNERS II, L.P.
 PROSPECT ASSOCIATES II, L.P.
 435 Tasso Street, Suite
200
 Palo Alto, CA 94301
 Attn: Russell
Hirsch

			
	 MPM BIOVENTURES III, L.P.
 MPM BIOVENTURES III-QP, L.P.
 MPM
BIOVENTURES III GMBH & CO. BETEILIGUNGS KG
 MPM
BIOVENTURES III PARALLEL FUND, L.P.
 MPM ASSET
MANAGEMENT INVESTORS 2003 BVIII LLC
 200 Clarendon Street, 54th Floor

Boston, MA 02116
 Attn: Nicholas
Galakatos
  
 FRAZIER HEALTHCARE IV,
LP
 FRAZIER AFFILIATES IV, LP
 Two Union Square
 601 Union Street, Suite 3200

Seattle, WA 98101
 Attn: Alan Frazier

 
 ABINGWORTH BIOVENTURES IV LP

ABINGWORTH BIOVENTURES IV EXECUTIVES LP
 38 Jermyn Street
 London SWIY 6DN
 Attn: Mike Bigham and General Counsel
  
 MILLENNIUM PHARMACEUTICALS, INC.
 75 Sidney
Street
 Cambridge, MA 02139
 Attn:
General Counsel
  
 DAVID E. SWEET
AND ROBIN T. SWEET AS TRUSTEES OF THE DAVID AND ROBIN SWEET LIVING
TRUST DATE 7/6/04
 755 Page Mill Road, Suite A-200
 Palo Alto, CA 94306
  

PATRICIA TOM

755 Page Mill Road, Suite A-200
 Palo Alto, CA
94306
  
 WELLS FARGO BANK,
N.A. FBO SHV PROFIT SHARING PLAN FBO WILLIAM H. YOUNGER, JR.
 Attn: Thomas M. Thurston
 600 California Street 12th Floor

San Francisco, CA 94108
	 	 WELLS FARGO BANK, N.A. FBO SHV PROFIT SHARING
PLAN FBO JAMES C. GAITHER
 Attn: Thomas M. Thurston

600 California Street 12th Floor
 San Francisco,
CA 94108
  
 EDWARD SCOLNICK

1201 Magnolia Drive
 Wayland, MA 01778

 
 LAWRENCE S. JACOBS

2059 Mastlands
 Oakland, CA 94611

 
 VAUGHN M. KAILIAN

601 Gateway Blvd., Suite 350
 South San
Francisco, CA 94080
  
 ADVANCED TECHNOLOGY
VENTURES VII, L.P.
 ADVANCED TECHNOLOGY VENTURES VII (B), L.P.

ADVANCED TECHNOLOGY VENTURES VII (C), L.P.
 1000 Winter Street, Suite 3700
 Waltham, MA 02451

Attn: Jean George
  
 ATV ENTREPRENEURS VII, L.P.
 1000 Winter Street, Suite 3700

Waltham, MA 02451
  
 GENERAL ELECTRIC CAPITAL CORPORATION
 83 Wooster Heights Road
 Danbury, CT 06810
 Attn: Credit Manager-Life Science and
 Technology Finance

			
	 ALTA BIOPHARMA PARTNERS III, L.P.

ALTA BIOPHARMA PARTNERS III GMBH & CO.
BETEILIGUNGS KG
 ALTA EMBARCADERO BIOPHARMA
PARTNERS III, LLC
 One Embarcadero Center, Suite 4050
 San Francisco, CA 94111
 Attn: Elaine Penny

 
 HERCULES TECHNOLOGY GROWTH
CAPITAL
 525 University Avenue, Suite 700
 Palo Alto, CA 94301
  

BOSTON LIFE SCIENCE VENTURE CORPORATION

2F, No. 97, Sung-Jen Road
 Taipei 110, Taiwan
(mailing address)
 5F, No. 420, Fu-Hsin N. Road, Taipei 104,
 Taiwan
 Attn: Dr. Peter T. K. Wu

 
 GRAND CATHAY VENTURE
CAPITAL III CO., LTD.
 3F., No. 245, Tun Hua S. Road, Sec. 1,

Taipei 106, Taiwan
 Attn: Edward Chang

 
 THE ROBERT LEE
DOUGLAS JR. AND ELIZABETH A. STRODE REVOCABLE TRUST DATED 10/6/94
 605 Woodmont Ave.
 Berkeley, CA 94708

 
 TOM AND PEGGY
PHILLIPS
 8061 Lakemont Dr NE
 Seattle, WA 98115
  

GC&H INVESTMENTS, LLC

c/o Cooley LLP
 101 California Street

San Francisco, CA 94111-3580
 Attn: James
Kindler
	 	 LOBSTERCREW & CO.
 c/o T. Rowe Price Associates, Inc.,
 100 East Pratt Street

Baltimore, MD 21202
 Attn: Darrell N.
Braman
 Attn: Bonnie L. Maher

Facsimile: (410) 345-6575
 Email:
Darrell_braman@troweprice.com
  
 GOLDMAN
SACHS INVESTMENT PARTNERS MASTER FUND, L.P.
 Attn: Annette S.
McGillicuddy
 85 Broad Street, 28th Floor
 New
York, NY 10004
  
 BROOKSIDE CAPITAL
PARTNERS FUND LP
 111 Huntington Ave
 Boston, MA 02199
 Attn: Adam Koppel

 
 BAKER BROS. INVESTMENTS II,
L.P.
 667 Madison Ave., 17th Floor

New York, NY 10021
 Attn: Felix Baker

 
 BAKER BROTHERS LIFE
SCIENCES
 667 Madison Ave., 17th Floor
 New York, NY 10021
 Attn: Felix Baker

 
 14159, L.P.
 667 Madison Ave., 17th Floor
 New York, NY 10021

Attn: Felix Baker
  
 ALLIANCEBERNSTEIN VENTURE FUND I, L.P.
 1345 Avenue of the Americas
 New York, NY 10105

Attn: Greg Raskin, M.D.
  
 BLACKBOARD VENTURES INC.
 c/o Ontario
Teachers’ Pension Plan Board
 5650 Yonge Street
 Toronto, Ontario M2M 4H5 Canada
 Attn: Terry Woodward

			
	 GREGORY P. SANDS, TRUSTEE OF GREGORY P.
SANDS REMAINDER UNITRUST
 755 Page Mill Road, Suite A-200

Palo Alto, CA 94306
  
 JIM WEISS
 529 Alta Way

Mill Valley CA 94941
  
 MICHAEL COONEY
 185 Booth Hill Road

Scituate, MA 02066
  
 SHAUN R. COUGHLIN
 2 Turtle Rock Ct.

Tiburon, CA 94920
  
 THOMAS P. REILLY
 29 Myers Farm Road

Hingham, MA 02043
  
 DAVID L. ANDERSON, TRUSTEE OF THE ANDERSON LIVING TRUST U/A/D
1/22/98
 755 Page Mill Road, Suite A-200
 Palo Alto, CA 94306
  

THE LAUREN YOUNGER LIVING TRUST U/A/D 7/30/2009

755 Page Mill Road, Suite A-200
 Palo Alto, CA
94306
  
 GREGORY P. SANDS,
TRUSTEE OF THE GREGORY P. SANDS REMAINDER UNITRUST
 755 Page Mill Road, Suite A-200
 Palo Alto, CA 94306

 
 JAMES C. GAITHER, TRUSTEE
OF THE GAITHER REVOCABLE TRUST U/A/D 9/28/2000
 755 Page Mill
Road, Suite A-200
 Palo Alto, CA 94306
  

TALLACK PARTNERS, L.P.
 755 Page Mill Road, Suite A-200
 Palo Alto, CA 94306
	  	 JAMES C. GAITHER, CUSTODIAN FBO JULIE A. YOUNGER
UNDER CUTMA UNTIL AGE 21
 JAMES C. GAITHER,
CUSTODIAN FBO KELLY L. YOUNGER UNDER CUTMA UNTIL AGE 21
 755 Page Mill Road, Suite A-200
 Palo Alto, CA 94306

 
 LYNNE M. BROWN

755 Page Mill Road, Suite A-200
 Palo Alto, CA
94306
  
 ROBERT YIN AND
LILY YIN AS TRUSTEES OF YIN FAMILY TRUST DATED MARCH 1, 1997

755 Page Mill Road, Suite A-200
 Palo Alto, CA
94306
  
 MICHAEL I. NAAR AND
DIANE J. NAAR AS TRUSTEES OF NAAR FAMILY TRUST U/A/D 12/22/94
 755 Page Mill Road, Suite A-200
 Palo Alto, CA 94306

 
 YOVEST, L.P.

755 Page Mill Road, Suite A-200
 Palo Alto, CA
94306
  
 ANDREW T. SHEEHAN
AND NICOLE J. SHEEHAN AS TRUSTEES OF SHEEHAN 2003 TRUST
 755 Page Mill Road, Suite A-200
 Palo Alto, CA 94306

 
 MARK YOUNGER

755 Page Mill Road, Suite A-200
 Palo Alto, CA
94306
  
 MICHAEL L. SPEISER
AND MARY ELIZABETH SPEISER, CO TRUSTEES OF SPEISER TRUST AGREEMENT DATED
7/19/06
 755 Page Mill Road, Suite A-200
 Palo Alto, CA 94306

			
	 WELLS FARGO BANK, TRUSTEE SHV PROFIT
SHARING PLAN FBO SHERRYL W. HOSSACK
 Attn: Thomas M. Thurston

600 California Street 12th Floor
 San Francisco,
CA 94108
  
 WELLS FARGO
BANK, TRUSTEE SHV PROFIT SHARING PLAN FBO LYNNE M. BROWN
 Attn: Thomas M. Thurston
 600 California Street 12th Floor

San Francisco, CA 94108
  
 WELLS FARGO BANK, TRUSTEE SHV PROFIT SHARING PLAN FBO ROBERT
YIN
 Attn: Thomas M. Thurston
 600 California Street 12th Floor
 San Francisco, CA 94108

 
 WELLS FARGO BANK,
TRUSTEE SHV PROFIT SHARING PLAN FBO PATRICIA TOM (POST)
 Attn: Thomas M. Thurston
 600 California Street 12th Floor

San Francisco, CA 94108
  
 WELLS FARGO BANK, TRUSTEE SHV PROFIT SHARING PLAN FBO DAVID L.
ANDERSON
 Attn: Thomas M. Thurston
 600 California Street 12th Floor
 San Francisco, CA 94108

 
 WELLS FARGO BANK, N.A. FBO SHV
PROFIT SHARING PLAN FBO LYNNE B. GRAW (ROLLOVER)

Attn: Thomas M. Thurston
 600 California Street
12th Floor
 San Francisco, CA 94108
  

WELLS FARGO BANK, N.A. FBO JAMES N. WHITE ROTH
IRA
 Attn: Thomas M. Thurston
 600
California Street 12th Floor
 San Francisco, CA 94108
	  	 WELLS FARGO BANK, N.A. FBO SHV PROFIT SHARING
PLAN FBO DAVID E. SWEET
 Attn: Thomas M. Thurston

600 California Street 12th Floor
 San Francisco,
CA 94108
  
 WELLS FARGO
BANK, N.A. FBO SHV PROFIT SHARING PLAN FBO TENCH COXE
 Attn: Thomas M. Thurston
 600 California Street 12th Floor

San Francisco, CA 94108
  
 WELLS FARGO BANK, N.A. FBO SHV PROFIT SHARING PLAN FBO DIANE J.
NAAR
 Attn: Thomas M. Thurston
 600 California Street 12th Floor
 San Francisco, CA 94108

 
 WELLS FARGO BANK, N.A. FBO SHV
PROFIT SHARING PLAN FBO YU-YING CHEN
 Attn: Thomas
M. Thurston
 600 California Street 12th Floor
 San Francisco, CA 94108
  

WELLS FARGO BANK, N.A. FBO SHV PROFIT SHARING PLAN FBO
LYNNE M. BROWN (ROLLOVER)
 Attn: Thomas M. Thurston

600 California Street 12th Floor
 San Francisco,
CA 94108
  
 WELLS FARGO
BANK, N.A. FBO SHV PROFIT SHARING PLAN FBO SHERRYL W. CASELLA
 Attn: Thomas M. Thurston
 600 California Street 12th Floor

San Francisco, CA 94108
  
 WELLS FARGO BANK, N.A. FBO SHV P/S FBO LAUREN YOUNGER
 Attn: Thomas M. Thurston
 600 California Street 12th Floor

San Francisco, CA 94108

			
	 WELLS FARGO BANK, N.A. FBO SHV P/S FBO YOUNGER, W.H.,
JR.
 Attn: Thomas M. Thurston
 600 California Street 12th Floor
 San Francisco, CA 94108

 
 WELLS FARGO BANK, N.A. FBO
GREGORY P. SANDS ROTH IRA
 Attn: Thomas M. Thurston

600 California Street 12th Floor
 San Francisco,
CA 94108
  
 WELLS FARGO
BANK, N.A. FBO
 SHV PROFIT SHARING PLAN

FBO ANDREW T. SHEEHAN (ROLLOVER)
 Attn: Thomas M. Thurston
 600 California Street 12th Floor

San Francisco, CA 94108
  
 667, L.P.
 667 Madison Ave., 17th Floor

New York, NY 10021
 Attn: Felix Baker

 
 JANUS INVESTMENT FUND
ON BEHALF OF THE PARTICIPATING SERIES PORTFOLIO IN EXHIBIT A-1 OF THE
SERIES C PREFERRED STOCK PURCHASE AGREEMENT, DATED JULY 9, 2010
 151 Detroit Street
 Denver, CO 80206
 Attn: Rick Noyes
 Attn: Angela Morton

 
 JANUS ASPEN SERIES ON
BEHALF OF THE PARTICIPATING SERIES PORTFOLIO IN EXHIBIT A-1 OF THE SERIES C
PREFERRED STOCK PURCHASE AGREEMENT, DATED JULY 9, 2010
 151 Detroit Street
 Denver, CO 80206
 Attn: Rick Noyes
 Attn: Angela Morton
	  	 BBT FUND, L.P.
 201 Main Street, Suite 3200
 Fort Worth, TX 76102

Attn: William O. Reimann
  

PAC-LINK BIO VENTURE CAPITAL INVESTMENT CORPORATION

16 Fl., 2, Sec 2, Tun Hwa South Road
 Taipei,
Taiwan, 10683, ROC
 Attn: Shan Ko Hsu
  

D.E. SHAW VALENCE PORTFOLIOS, L.L.C.
 D. E. Shaw & Co., L.P.
 120 W 45th St, 39th Floor NY,

NY 10036
 Attn: Jim Mackey, M.D.

 
 ADAGE CAPITAL PARTNERS,
L.P.
 200 Clarendon St., 52nd

Boston, MA 02116
 Attn: Dan Lehan

 
 GC PARTNERS LP

c/o Cooley LLP
 101 California Street

San Francisco, CA 94111-3580
 Attn: James
KindlerLicense and Collaboration Agreement

 Exhibit 10.7 
 [*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the
Securities Act of 1933, as amended. 
 EXECUTION COPY 

 
  

License and Collaboration Agreement 
 by and between 
 Portola Pharmaceuticals, Inc. 

and 

Biogen Idec MA Inc. 
  

 

 Table of Contents 

(continued) 
  

							
	 	  	Page	 
		
	 ARTICLE 1 DEFINITIONS
	  	 	1	  
		
	 ARTICLE 2 LICENSE
	  	 	14	  
	 2.1
	 	 License Grant
	  	 	14	  
	 2.2
	 	 Sublicense and Subcontract Rights
	  	 	15	  
	 2.3
	 	 Portola’s Retained Rights
	  	 	15	  
	 2.4
	 	 Exclusivity
	  	 	15	  
	 2.5
	 	 No Implied Licenses; Negative Covenant
	  	 	16	  
	 2.6
	 	 Disclosure of Know-How
	  	 	16	  
	 2.7
	 	 Retained Field
	  	 	17	  
		
	 ARTICLE 3 GOVERNANCE
	  	 	17	  
	 3.1
	 	 Alliance Managers
	  	 	17	  
	 3.2
	 	 Joint Steering Committee
	  	 	17	  
	 3.3
	 	 Meetings of the Joint Steering Committee
	  	 	18	  
	 3.4
	 	 Decision Making
	  	 	18	  
	 3.5
	 	 Sub-Committees; Joint Development Team
	  	 	19	  
	 3.6
	 	 Costs of Governance
	  	 	20	  
	 3.7
	 	 Discontinuation of Participation on a Committee
	  	 	20	  
		
	 ARTICLE 4 DEVELOPMENT
	  	 	20	  
	 4.1
	 	 Development Generally
	  	 	20	  
	 4.2
	 	 Portola Development Activities
	  	 	23	  
	 4.3
	 	 Biogen Idec Development Activities
	  	 	23	  
	 4.4
	 	 Compliance
	  	 	24	  
	 4.5
	 	 Development Expenses
	  	 	24	  
		
	 ARTICLE 5 Regulatory
	  	 	25	  
	 5.1
	 	 Transition to Biogen Idec
	  	 	25	  
	 5.2
	 	 Regulatory Responsibilities
	  	 	26	  
	 5.3
	 	 Regulatory Matters Prior to Transition Date and for Niche Indications
	  	 	26	  
		
	 ARTICLE 6 Manufacturing
	  	 	27	  
	 6.1
	 	 Supply for Clinical Trials
	  	 	27	  
	 6.2
	 	 Portola’s Transfer of Portola Manufacturing Know-How to Biogen Idec
	  	 	27	  
	 6.3
	 	 Commercial Supply
	  	 	28	  
	 6.4
	 	 Portola’s Right to Manufacture
	  	 	29	  
	 6.5
	 	 Manufacturing Costs and Related Costs
	  	 	29	  
	 6.6
	 	 Manufactured Products
	  	 	30	  
		
	 ARTICLE 7 COMMERCIALIZATION
	  	 	30	  
	 7.1
	 	 Commercialization
	  	 	30	  
	 7.2
	 	 Portola Commercialization and Co-Promotion Rights
	  	 	31	  
	 7.3
	 	 Product Recalls
	  	 	33	  
	 7.4
	 	 Pharmacovigilance
	  	 	33	  

  
 [*] = Certain confidential
information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 Table of Contents 

(continued) 
  

							
	 	  	Page	 
		
	 ARTICLE 8 FINANCIAL PROVISIONS
	  	 	35	  
	 8.1
	 	 Upfront Payment and Investment
	  	 	35	  
	 8.2
	 	 Milestone Payments
	  	 	35	  
	 8.3
	 	 Profit Sharing of Co-Developed Product in the Profit Share Territory
	  	 	38	  
	 8.4
	 	 Royalty Payments
	  	 	39	  
	 8.5
	 	 Third Party Obligations
	  	 	40	  
	 8.6
	 	 Limit on Royalty Reduction
	  	 	41	  
	 8.7
	 	 Tax
	  	 	41	  
		
	 ARTICLE 9 INTELLECTUAL PROPERTY RIGHTS
	  	 	42	  
	 9.1
	 	 Ownership of Inventions
	  	 	42	  
	 9.2
	 	 Patent Prosecution
	  	 	42	  
	 9.3
	 	 Patent Enforcement
	  	 	43	  
	 9.4
	 	 Patent Licensed From Third Parties
	  	 	44	  
	 9.5
	 	 Trademarks
	  	 	44	  
	 9.6
	 	 Patent Extensions
	  	 	45	  
		
	 ARTICLE 10 CONFIDENTIALITY; PUBLICATION
	  	 	45	  
	 10.1
	 	 Duty of Confidence
	  	 	45	  
	 10.2
	 	 Exceptions
	  	 	45	  
	 10.3
	 	 Authorized Disclosures
	  	 	46	  
	 10.4
	 	 Publication
	  	 	47	  
	 10.5
	 	 Publicity/Use of Names
	  	 	47	  
		
	 ARTICLE 11 TERM AND TERMINATION
	  	 	48	  
	 11.1
	 	 Term
	  	 	48	  
	 11.2
	 	 Termination by Portola
	  	 	49	  
	 11.3
	 	 Termination by Biogen Idec
	  	 	49	  
	 11.4
	 	 Consequence for Inability to Co-Fund or Co-Promote
	  	 	50	  
	 11.5
	 	 Effects of Termination
	  	 	50	  
	 11.6
	 	 Accrued Rights
	  	 	53	  
	 11.7
	 	 Survival
	  	 	53	  
	 11.8
	 	 Provision for Insolvency
	  	 	53	  
	 11.9
	 	 Licenses
	  	 	53	  
	 11.10
	 	 Rights to Intellectual Property
	  	 	54	  
	 11.11
	 	 Additional Rights
	  	 	54	  
	 11.12
	 	 Termination Not Sole Remedy
	  	 	54	  
		
	 ARTICLE 12 REPRESENTATIONS AND WARRANTIES
	  	 	55	  
	 12.1
	 	 Representations and Warranties of Each Party
	  	 	55	  
	 12.2
	 	 Representations and Warranties by Portola
	  	 	55	  
	 12.3
	 	 No Other Warranties
	  	 	56	  
		
	 ARTICLE 13 INDEMNIFICATION; LIABILITY
	  	 	56	  
	 13.1
	 	 Indemnification by Portola
	  	 	56	  
	 13.2
	 	 Indemnification by Biogen Idec
	  	 	56	  

  
 [*] = Certain confidential
information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 Table of Contents 

(continued) 
  

							
	 	 	 	  	Page	 
			
	 13.3
	 	 Product Liability
	  	 	57	  
	 13.4
	 	 Indemnification Procedure
	  	 	57	  
	 13.5
	 	 Mitigation of Loss
	  	 	58	  
	 13.6
	 	 Special, Indirect and Other Losses
	  	 	58	  
		
	 ARTICLE 14 GENERAL PROVISIONS
	  	 	58	  
	 14.1
	 	 Force Majeure
	  	 	58	  
	 14.2
	 	 Assignment
	  	 	59	  
	 14.3
	 	 Change of Control
	  	 	59	  
	 14.4
	 	 Severability
	  	 	59	  
	 14.5
	 	 Notices
	  	 	59	  
	 14.6
	 	 Governing Law
	  	 	60	  
	 14.7
	 	 Consent to Jurisdiction
	  	 	60	  
	 14.8
	 	 Entire Agreement; Amendments
	  	 	61	  
	 14.9
	 	 Headings
	  	 	61	  
	 14.10
	 	 Export Control
	  	 	61	  
	 14.11
	 	 Independent Contractors
	  	 	61	  
	 14.12
	 	 Waiver
	  	 	61	  
	 14.13
	 	 Cumulative Remedies
	  	 	62	  
	 14.14
	 	 Waiver of Rule of Construction
	  	 	62	  
	 14.15
	 	 Counterparts
	  	 	62	  
	 14.16
	 	 Antitrust Filings.
	  	 	62	  
	 14.17
	 	 No Third Party Rights or Obligations
	  	 	63	  
	 14.18
	 	 Further Actions
	  	 	63	  
	 14.19
	 	 Affiliates
	  	 	63	  

  
 [*] = Certain confidential
information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 LICENSE AND COLLABORATION AGREEMENT 

This LICENSE AND COLLABORATION AGREEMENT (“Agreement”) is made as of this 26th day of October, 2011 (“Execution Date”), by and
between Biogen Idec MA Inc., a corporation organized and existing under the laws of Massachusetts, having its principal place of business at 14 Cambridge Center, Cambridge, Massachusetts (“Biogen Idec”) and Portola Pharmaceuticals,
Inc., a corporation organized and existing under the laws of Delaware, having its principal place of business at 270 East Grand Avenue, Suite 22, South San Francisco, CA 94080, USA (“Portola”). Biogen Idec and Portola are referred
to individually as a “Party” and collectively as the “Parties.” 
 RECITALS 

WHEREAS, Portola is engaged in the development of innovative therapeutics for cardiovascular disease, inflammatory disease and cancer;

 WHEREAS, Biogen Idec is a pharmaceutical company with expertise in developing and commercializing pharmaceutical products;

 WHEREAS, Portola controls certain patents and know-how relating to its proprietary Syk kinase inhibitor program, including
patents and know-how covering the lead compound and backup compounds in such program; and 
 WHEREAS, Biogen Idec wishes to
obtain from Portola the exclusive rights to develop and commercialize such lead compound and its related backup compounds, and Portola wishes to grant such rights to Biogen Idec, all under the terms and conditions set forth herein. 

NOW, THEREFORE, in consideration of the foregoing premises and the mutual covenants herein contained, the receipt and sufficiency which
are hereby acknowledged, Biogen Idec and Portola hereby agree as follows. 
 ARTICLE 1 

DEFINITIONS 
 Unless the context otherwise requires, the terms in this Agreement with initial letters capitalized, shall have the meanings set forth below, or the meaning as designated in the indicated places
throughout this Agreement. 
 1.1 “Active Ingredient” or “API” means, in a pharmaceutical
product, a clinically active material that provides pharmacological activity or a pro-drug therefor (excluding formulation components such as coatings, stabilizers, excipients or solvents, adjuvants or controlled release technologies). 

1.2 “Affiliate” means, with respect to a Party, any person that controls, is controlled by, or is under common control
with that Party. For the purpose of this definition, “control” means any of the following: (a) direct or indirect ownership of more than fifty percent (50%) of the shares of stock entitled to vote for the election of directors in
the case of a corporation; (b)

  
 1 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
direct or indirect ownership of more than fifty percent (50%) of the equity interest in the case of any other type of legal entity; (c) status as a general partner in any partnership or
(d) any other arrangement whereby the entity or person: (i) controls or has the right to control the board of directors or equivalent governing body of a corporation or other entity; or (ii) possesses the ability to cause the
direction of the management or policies of a corporation or other entity. 
 1.3 “Alliance Manager” has the
meaning set forth in Section 3.1. 
 1.4 “Astellas” means Astellas Pharma Inc. and any successor entities
thereof. 
 1.5 “Astellas Agreement” means the License Agreement by and between Portola and Astellas, effective
on May 13, 2005, as amended and restated on March 16, 2009 and December 20, 2010, and as further amended from time to time. 
 1.6 “Audited Party” has the meaning set forth in the Financial Exhibit. 
 1.7 “Auditing Party” has the meaning set forth in the Financial Exhibit. 
 1.8 “Back-Up Compound” means any Syk Selective Inhibitor (other than the Lead Compound), including any prodrug, metabolite, [*] salt form or radio-labeled form thereof, that is, as of the
Execution Date, or becomes, during the Term, Controlled by Portola or by Biogen Idec, except as part of an Exempted Program under Section 2.4(a). Back-Up Compound shall include [*]. 

1.9 “Biogen Idec Co-Promotion Term” has the meaning set forth in Section 7.2(a)(ii). 

1.10 “Biogen Idec Estimate” has the meaning set forth in Section 7.2(b)(ii). 

1.11 “Biogen Idec Indemnitees” has the meaning set forth in Section 13.1. 

1.12 “Biogen Idec Know-How” means any Know-How Controlled by Biogen Idec or any of its Affiliates as of the Execution
Date or thereafter during the Term relating to the Collaboration Compounds and/or Products that is necessary or reasonably useful for the Development, Manufacture, use or commercialization of the Collaboration Compounds and/or Products in the
Licensed Field. 
 1.13 “Biogen Idec [*]” has the meaning set forth in Section [*]. 

1.14 “Biogen Idec Patents” means any Patent Rights Controlled by Biogen Idec or any of its Affiliates as of the
Execution Date or thereafter during the Term that claim the Collaboration Compounds and/or Products or their composition, formulation, Manufacture or use in the Licensed Field. 

1.15 “Biogen Idec Technology” means Biogen Idec Know-How and Biogen Idec Patents. 

  
 2 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 1.16 “Calendar Quarter” means the respective periods of three
(3) consecutive calendar months ending on March 31, June 30, September 30 and December 31. 

1.17 “Calendar Year” means a period of twelve (12) consecutive calendar months ending on December 31.

 1.18 “Certain Acquirer” means any of [*], and any successor thereto or any acquirer of rights in any
pharmaceutical product of such entities which, as of the relevant Certain Change of Control Event, has been advanced to at least the commencement of [*] or any acquirer of rights in any of the following products: [*]. 

1.19 “Certain Change of Control Event” means a Change of Control of Portola pursuant to which Portola is acquired by or
otherwise becomes an Affiliate of a Certain Acquirer. 
 1.20 “cGMPs” means all current applicable laws and
regulation that apply to the Manufacture of Active Ingredients and pharmaceutical products, including but not limited to, as applicable, (a) the United States regulations set forth under Title 21 of the United States Code of Federal Regulations
parts 210, 211, as may be amended from time to time as well as applicable guidance published by the FDA from time to time; (b) the EU good manufacturing practices set forth in the European Community directive 2003/94/EC, Directive 2001/83/EC,
all relevant implementations of such directive and relevant guidelines including Volume 4 of the Rules Governing Medicinal Products in the European Union: Medicinal Products for Human and Veterinary Use; and (c) the Ministry of Health Labor and
Welfare GMP/GQP ordinances and accompanying regulations in Japan, in each case as may be modified or supplemented during the Term. 
 1.21 “Change of Control” means, with respect to a particular Party: (a) the sale of all or substantially all of such Party’s (or any of its controlling Affiliates’) assets
or business relating to the subject matter of this Agreement; (b) a merger, reorganization or consolidation involving such Party (or a controlling Affiliate thereof) in which the voting securities of such Party (or such controlling Affiliate,
as applicable) outstanding immediately prior thereto cease to represent at least fifty percent (50%) of the combined voting power of the surviving entity immediately after such merger, reorganization or consolidation; or (c) the
acquisition by a person or entity of more than fifty percent (50%) of the voting equity securities or management control of such Party (or a controlling Affiliate thereof) as a result of a single transaction or a series of related transactions.

 1.22 “Claims” has the meaning set forth in Section 13.1. 

1.23 “Collaboration Budget” has the meaning set forth in the Financial Exhibit. 

1.24 “Collaboration Compound” means any of Lead Compound and/or Back-Up Compounds. 

1.25 “Collaboration Operating Profit (or Loss)” has the meaning set forth in the Financial Exhibit. 

1.26 “Combination Product” has the meaning set forth in the Financial Exhibit. 

  
 3 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 1.27 “Combination Product Amount” has the meaning set forth in the
Financial Exhibit. 
 1.28 “Commence” or “Commencement” means, with respect to a clinical
trial, the first dosing of the first human subject with a Collaboration Compound or Product. 
 1.29 “Commercialization
Plan” has the meaning set forth in Section 7.1(c). 
 1.30 “Commercially Reasonable Efforts”
means, with respect to the efforts to be expended by a Party pertaining to a particular objective, the objective, reasonable, diligent, good faith efforts to accomplish such objective in an active and ongoing program as a similarly situated (with
respect to size, stage of development, and assets) biotechnology or pharmaceutical company, as the case may be, would use to accomplish a similar objective under similar circumstances exercising reasonable business judgment, taking into account the
following factors to the extent applicable: stage of development, [*] efficacy and safety issues, characteristics of competitive products in or anticipated to be in the marketplace, [*] Third Party intellectual property rights, actual or anticipated
[*], the nature and extent of market exclusivity (including patent coverage and regulatory exclusivity), cost and likelihood of obtaining Regulatory Approval, and projected or actual economic return (without taking into consideration the economic
terms in this Agreement in comparison with other programs of such Party). Commercially Reasonable Efforts shall be determined on a market-by-market and indication-by-indication basis for a particular Product, and it is anticipated that the level of
effort may be different for different markets, and may change over time, reflecting changes in the status of each such Product and the market(s) involved. 
 1.31 “Confidential Information” means all proprietary Know-How, unpublished patent applications and other information and data of a financial, commercial or technical nature which the
disclosing Party or any of its Affiliates has supplied or otherwise made available to the other Party or its Affiliates, whether made available orally, in writing or in electronic form, including information comprising or relating to concepts,
discoveries, inventions, data, designs or formulae in relation to this Agreement. 
 1.32 “Confidentiality
Agreement” has the meaning set forth in Section 14.8. 
 1.33 “Contract Manufacturer” means any
Third Party contract manufacturer (including toll manufacturers) with which Biogen Idec or Portola or any of their Affiliates contracts for the Manufacture of any Collaboration Compound or Product. 

1.34 “Control” or “Controlled” means, with respect to any Know-How, Patent Rights, other intellectual
property rights, or any proprietary or trade secret information, the legal authority or right (whether by ownership, license or otherwise) of a Party to grant a license or a sublicense under such Know-How, Patent Rights, or intellectual property
rights to another Person, or to otherwise disclose such proprietary or trade secret information to another Person, without breaching the terms of any agreement with a Third Party, or misappropriating the proprietary or trade secret information of a
Third Party. 
 1.35 “Co-Promotion/Co-Promote” means co-detailing activities of the Products to healthcare
professionals to be conducted by Biogen Idec in the United States in the event Biogen 

  
 4 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
Idec exercises its rights under Section 7.2(a); and/or by Portola in the United States in the event that Portola exercises its rights under Section 7.2(b). 

1.36 “Co-Promotion Agreement” has the meaning set forth in Section 7.2(b)(vi). 

1.37 “Co-Promotion Option” has the meaning set forth in Section 7.2(b)(ii). 

1.38 “Cost of Clinical Supplies” has the meaning set forth in the Financial Exhibit. 

1.39 “Cost of Goods Manufactured for Sale (COGM)” has the meaning set forth in the Financial Exhibit. 

1.40 “Cost of Sales” has the meaning set forth in the Financial Exhibit. 

1.41 “Detail” means an in-person interaction between a sales representative and a Prescriber for the purposes of
informing such Prescriber of the characteristics of the Products and providing Product-related information and/or services. When used as a verb, the term “Detail” or “Detailing” means to perform a Detail.

 1.42 “Develop” or “Development” means the research and development activities for a
Collaboration Compound, or Product, including, without limitation, discovery or identification of Collaboration Compounds, preclinical and clinical activities and studies designed to obtain any Regulatory Approval of such Product, Manufacturing
Development, toxicology studies, Manufacture and distribution of Collaboration Compounds and Products for use in clinical trials, including placebos and comparators as the case may be, statistical analysis, the preparation, filing and prosecution of
NDAs and MAAs, and all regulatory affairs related to the foregoing. 
 1.43 “Development Expenses” has the
meaning set forth in the Financial Exhibit. 
 1.44 “Development Plan” means the plan attached hereto as
Exhibit A for the Parties’ Development of Collaboration Compounds and the Products [*], including the related Development Budget, in each case as amended from time to time and approved by the JDC or JSC, as applicable pursuant to Article
4. 
 1.45 “Distribution Costs” has the meaning set forth in the Financial Exhibit. 

1.46 “DMF” means a Drug Master File maintained with the FDA or its equivalent maintained with a Regulatory Authority in
other countries. 
 1.47 “Effective Date” means the date this Agreement becomes effective as determined in
accordance with Section 14.16. 
 1.48 “EMA” means the European Medicines Agency or any successor entity
thereto. 
 1.49 “[*]” has the meaning set forth in Section [*]. 

1.50 “Excess Product Liability Costs” has the meaning set forth in Section 13.3. 

1.51 “Exempted Program” has the meaning set forth in Section 2.4(a). 

  
 5 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 1.52 “Ex-US Commercial Profit (or Loss)” means the Collaboration Operating
Profit (or Loss) resulting from the Commercialization of Products in countries of the Profit Share Territory other than the United States, provided that for the purposes solely of this definition, Operating Expenses shall exclude Development
Expenses and Ongoing Development Expense incurred by or on behalf of a Party or the Parties jointly for the purpose of obtaining or maintaining Regulatory Approval outside of the United States. 

1.53 “FDA” means the United States Food and Drug Administration or any successor entity thereto. 

1.54 “Filing” of an NDA means the acceptance by a Regulatory Authority of an NDA for filing, if applicable, or the date
of filing if the applicable regulatory jurisdiction does not have an “acceptance” process or requirement. 
 1.55
“Financial Exhibit” means the financial planning, accounting and reporting procedures related to this Agreement attached hereto as Financial Exhibit. 
 1.56 “First Commercial Sale” means, with respect to any Product, the first sale to an unrelated Third Party in a bona fide arms-length transaction for distribution, use or consumption of
any such Product in a country after the applicable Regulatory Approval has been obtained for such Product in such country, excluding compassionate use and/or named patient arrangements. 

1.57 “FTE Costs” has the meaning set forth in the Financial Exhibit. 

1.58 “Full Data Package” means, with respect to a completed Phase II Trial, all[*] data for such trial, including but
not limited to[*] in such trial (such as, in the case of trials conducted for rheumatoid arthritis, all relevant data with respect to [*]. 
 1.59 “Functional Currency” has the meaning set forth in the Financial Exhibit. 
 1.60 “GAAP” means generally accepted accounting principles as in effect in the United States and from time to time applied by Biogen Idec in its audited financial statements. 

1.61 “Generic Product” means, with respect to any Product in a particular country, a pharmaceutical product that:
(a) is sold by a Third Party that has not obtained the rights to sell such product as a licensee or sublicensee of Biogen Idec or any of its Affiliates or through a chain of commerce including such an entity; (b) is approved pursuant to an
abbreviated new drug application referencing the NDA for such Product or otherwise contains as an Active Ingredient the same Collaboration Compound (or a bioequivalent prodrug, metabolite, ester, stereoisomer, hydrate, solvate, or salt thereof) and
utilizes the same route of administration as such Product; and (c) is approved or otherwise lawfully marketed for human pharmaceutical use in such country. 
 1.62 “Go/No-go Decision” has the meaning set forth in Section 4.1(a). 
 1.63 “Gross Sales” has the meaning set forth in the Financial Exhibit. 

  
 6 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 1.64 “Government Exclusivity” means, with respect to any country of the
Territory, any additional market protection, beyond Patent Rights, granted by a Regulatory Authority in such country which confers an exclusive commercialization period during which Biogen Idec and/or any of its Affiliates, licensees and/or
sublicensees is granted the exclusive right to market and sell a Product in such country through a regulatory exclusivity right such as new chemical entity exclusivity, new use or indication exclusivity, orphan drug exclusivity, pediatric
exclusivity and any applicable data exclusivity. 
 1.65 “HSR Act” means the Hart-Scott-Rodino Antitrust
Improvements Act of 1976, as amended, and the rules promulgated thereunder. 
 1.66 “HSR Filing Date” has the
meaning set forth in Section 14.16. 
 1.67 “IND” means an Investigational New Drug application, Clinical
Study Application, Clinical Trial Exemption, or similar application or submission for approval to conduct human clinical investigations filed with or submitted to a Regulatory Authority in conformance with the requirements of such Regulatory
Authority. 
 1.68 “Indemnified Party” has the meaning set forth in Section 13.4. 

1.69 “Indemnifying Party” has the meaning set forth in Section 13.4. 

1.70 “Indication” means any human disease or condition in the Licensed Field which can be treated, prevented or cured or
the progression of which can be delayed and for which a Product is specifically developed in order to obtain regulatory approval for use of such Product pursuant to an approved label claim. A single Indication shall include the primary disease and
variants or subdivisions or subclassifications within such primary disease. Treatment, modulation and/or prophylaxis of the same disease, regardless of the patient population, shall be treated as the same Indication. Treatment as monotherapy or
treatment in combination with another product shall all be treated as the same Indication. For clarity (and without exclusion of other Indications), each indication set forth on Exhibit B shall be deemed a separate Indication for the purpose of this
Agreement, but label expansion within each indication set forth on Exhibit B shall not be considered a separate Indication. 

1.71 “Invention” means any process, method, composition of matter, article of manufacture, discovery or finding, whether
or not patentable, that is conceived and/or reduced to practice as a result of a Party, its Affiliate or a Third Party acting on behalf of such Party or Affiliate in the course of performance of any activities under the Development Plan or otherwise
exercising its rights or carrying out its obligations under this Agreement. 
 1.72 “Joint Commercialization
Committee” or “JCC” has the meaning set forth in Section 3.5(d). 
 1.73 “Joint
Development Committee” or “JDC” has the meaning set forth in Section 3.5(c). 
 1.74
“Joint Development Team” has the meaning set forth in Section 3.5(b). 

  
 7 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 1.75 “Joint Steering Committee” or “JSC” has the meaning
set forth in Section 3.2. 
 1.76 “[*] Niche Development” has the meaning set forth in Section [*].

 1.77 “Joint Invention” has the meaning set forth in Section 9.1. 

1.78 “Joint Know-How” means any Know-How within the Joint Inventions. 

1.79 “Joint Patents” means any Patent Rights claiming Joint Inventions. 

1.80 “Joint Technology” means Joint Know-How and Joint Patents. 

1.81 “Know-How” means any information and materials, including but not limited to, discoveries, improvements, processes,
methods, protocols, formulas, data, inventions, know-how and trade secrets, patentable or otherwise, but excluding any Patent Rights. 
 1.82 “Lead Compound” means Portola’s proprietary compound known as PRT062607 and having the structure set forth on Exhibit C to this Agreement, including any prodrug, metabolite,
stereoisomer, hydrate, solvate, salt form or radiolabeled form thereof. 
 1.83 “Licensed Field” means all
human diagnostic, therapeutic or prophylactic uses, provided that the Licensed Field shall exclude the Retained Field. 

1.84 “Losses” has the meaning set forth in Section 13.1. 

1.85 “Major Indication” means any Indication directed to rheumatoid arthritis, lupus, [*], allergic asthma, [*], or any
other Indication in the Licensed Field that is not a Niche Indication. 
 1.86 “Major Territory” means each of
the following: the United States, France, Germany, Italy, Spain, and the United Kingdom. 
 1.87 “Manufacture”
means all operations in the manufacture, receipt, incoming inspections, storage and handling of Materials, manufacture, processing, formulation, packaging, labeling, warehousing, quality control testing (including in-process release and stability
testing), shipping and release of Active Ingredient contained in a Product, Collaboration Compounds or Products, as the case may be and to the extent applicable. 
 1.88 “Manufacturing Development” all activities related to the optimization of a manufacturing process for the manufacture of Product (including Active Ingredients therefor), including
but not limited to, test method development and stability testing, formulation, validation, productivity, troubleshooting and second generation formulation, process development, manufacturing scale-up, development stage manufacturing and quality
assurance/quality control development. 
 1.89 “Manufacturing Transfer Period” has the meaning set forth in
Section 6.2(a). 

  
 8 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 1.90 “Marketing Application Authorization” or “MAA” means
an application for the authorization to market a Product in any country or group of countries outside the United States, as defined in the applicable laws and regulations and filed with the Regulatory Authority of a given country or group of
countries. 
 1.91 “Marketing Costs” has the meaning set forth in the Financial Exhibit. 

1.92 “Material Development Plan Amendment” has the meaning set forth in Section 3.2(b). 

1.93 “Materials” means all raw materials including any Active Ingredient, excipients, components, containers, labels and
packaging necessary for the Manufacture of Collaboration Compounds or Products. 
 1.94 “Medical Education
Costs” has the meaning set forth in the Financial Exhibit. 
 1.95 “Milestone Amount” has the meaning
set forth in Section 8.2(g). 
 1.96 “NDA” means a New Drug Application, Marketing Application
Authorization or similar application or submission for Regulatory Approval of a Product filed with a Regulatory Authority to obtain marketing approval for a biological or pharmaceutical product in that country or in that group of countries.

 1.97 “Net Sales” has the meaning set forth in the Financial Exhibit. 

1.98 “Niche Commercialization Option” has the meaning set forth in Section 7.2(a)(i). 

1.99 “Niche Development” has the meaning set forth in Section 4.1(c)(ii). 

1.100 “Niche Indication” shall have the meaning set forth in Section 4.1(c)(i). 

1.101 “Niche Indication [*]” has the meaning set forth in Section [*]. 

1.102 “Ongoing Development Expenses” has the meaning set forth in the Financial Exhibit. 

1.103 “Operating Expenses” has the meaning set forth in the Financial Exhibit. 

1.104 “Opt-Out Option” has the meaning set forth in Section 4.5(b). 

1.105 “Other Out-of-Pocket Expenses” has the meaning set forth in the Financial Exhibit. 

1.106 “Patent Expenses” has the meaning set forth in the Financial Exhibit. 

1.107 “Patent Rights” means all patents and patent applications (which for the purpose of this Agreement shall be deemed
to include certificates of invention and applications for certificates of invention), including all divisionals, continuations, substitutions, continuations-in-

  
 9 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
part, re-examinations, reissues, additions, renewals, revalidations, extensions, registrations, pediatric exclusivity periods and supplemental protection certificates and the like of any such
patents and patent applications, and any and all foreign equivalents of the foregoing. 
 1.108 “Person” means
any individual, partnership, limited liability company, firm, corporation, association, trust, unincorporated organization or other entity. 
 1.109 “Phase I Clinical Trial” means a controlled human clinical trial that would satisfy the requirements of 21 CFR 312.21(a). 

1.110 “Phase II Clinical Trial” means a controlled human clinical trial that would satisfy the requirements of 21 CFR
312.21(b). 
 1.111 “Phase IIa Trial” shall mean a pilot Phase II Clinical Trial in the relevant human patient
population for the purpose of determining the safe and effective dose range for the proposed therapeutic indication of a product and other characteristics of safety and efficacy, as exemplified in 21 C.F.R. § 312.21(b). 

1.112 “Phase IIb Trial” means a well-controlled Phase II Clinical Trial in the relevant human patient population for the
purpose of determining safety and efficacy of the relevant product, as exemplified in 21 C.F.R. § 312.21(b). 
 1.113
“Phase III Clinical Trial” means a large, controlled or uncontrolled human clinical trial that would satisfy the requirements of 21 CFR 312.21(c). 
 1.114 “Phase IV Clinical Trial” has the meaning set forth in the Financial Exhibit. 
 1.115 “Portola Co-Promotion Effort” has the meaning set forth in Section 7.2(b)(iii). 
 1.116 “Portola Co-Promotion Term” has the meaning set forth in Section 7.2(b)(ii). 
 1.117 “Portola Development Activities” means all Development activities with respect to the Collaboration Compounds, and Products for which Portola is responsible under the Development
Plan and/or that are performed by or on behalf of Portola. 
 1.118 “Portola Indemnitees” has the meaning set
forth in Section 13.2. 
 1.119 “[*] Niche Development” has the meaning set forth in Section [*].

 1.120 “Portola Know-How” means any Know-How Controlled by Portola or any of its Affiliates as of the
Execution Date or thereafter during the Term relating to the Collaboration Compounds and/or Products that is necessary or reasonably useful for the Development, Manufacture, use or commercialization of the Collaboration Compounds and/or Products in
the Licensed Field. 
 1.121 “Portola Manufacturing Activities” has the meaning set forth in
Section 6.1(a). 

  
 10 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 1.122 “Portola Manufacturing Know-How” has the meaning set forth in
Section 6.2(a). 
 1.123 “Portola Patents” means any Patent Rights Controlled by Portola or any of its
Affiliates as of the Execution Date or thereafter during the Term that claim the Collaboration Compounds and/or Products or their composition, formulation, Manufacture or use in the Licensed Field. Portola represents that Portola Patents existing as
of the Execution Date are set forth on Exhibit D. 
 1.124 “Portola Technology” means the Portola Know-How
and Portola Patents. 
 1.125 “Post-Approval Clinical Trial” has the meaning set forth in the Financial
Exhibit. 
 1.126 “Prescriber” means any healthcare professional authorized to prescribe a Product. 

1.127 “Product” means (x) any pharmaceutical preparation in final form, including all dosage forms, formulations
and line extensions thereof, comprising Collaboration Compound, or (y) any diagnostic product intended to be used in connection with the Product described in (x) above that (1) identifies whether a patient is a candidate for treatment
with such Product, (2) assesses the efficacy of such Product, and/or (3) helps to define therapeutic objectives for treatment with such Product, in all cases within the Licensed Field. For clarity, for all purposes of the Agreement, all
Combination Products and single agent Products comprising the same Collaboration Compound (as well as all Products comprising any prodrug, metabolite, [*] salt form or radio-labeled form of such Collaboration Compound) shall be considered the same
Product, regardless of the formulation, dosage strength, route of administration, packaging or Product Indication thereof or any other Active Ingredient(s) contained therein. 
 1.128 “Product Infringement” has the meaning set forth in Section 9.3(a). 
 1.129 “Product Marks” has the meaning set forth in Section 9.5. 
 1.130 “Profit Share Territory” means, for a particular Product: (a) all countries and jurisdictions of the world so long as Portola has not exercised its Opt-Out Option for such
Product; or (b) none of the countries or jurisdictions if and only if Portola exercises its Opt-Out Option for such Product. 
 1.131 “[*]” means Portola’s proprietary compound known as [*] and having the structure set forth on Exhibit C to this Agreement. 

1.132 “[*]” means Portola’s proprietary compound known as [*] and having the structure set forth on Exhibit C
to this Agreement. 
 1.133 “Quarterly Forecast” has the meaning set forth in the Financial Exhibit.

 1.134 “[*]” means a [*] of a [*], [*] for [*] of [*] and [*] for [*]. 

  
 11 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 1.135 “Reconciliation Statement” has the meaning set forth in the Financial
Exhibit. 
 1.136 “Regulatory Approval” means, with respect to a Product in any country or jurisdiction, all
approvals, registrations, licenses or authorizations from the relevant Regulatory Authority in a country or jurisdiction that is specific to a Product and necessary to market and sell such Product in such country or jurisdiction. 

1.137 “Regulatory Authority” means any applicable government regulatory agency or authority responsible for granting
Regulatory Approvals for Products, including the FDA, EMA and any corresponding national or regional regulatory authorities. 

1.138 “Regulatory Filings” means, with respect to the Collaboration Compounds or Products, any submission to a
Regulatory Authority of any appropriate regulatory application pertaining to Collaboration Compounds or Products, and shall include, without limitation, any submission to a regulatory advisory board and any supplement or amendment thereto. For the
avoidance of doubt, Regulatory Filings shall include any IND, NDA, MAA or the corresponding application in any other country or group of countries. 
 1.139 “Regulatory Materials” has the meaning set forth in Section 5.1(a). 
 1.140 “Related Party” means, with respect to a Party, each of such Party itself, its Affiliates and their respective sublicensees, as applicable. 

1.141 “[*]” has the meaning set forth in Section [*]. 

1.142 “Remainder” has the meaning set forth in Section 9.3(e). 

1.143 “Retained Field” means [*] of a Product in [*] (for example but not limited to: [*]), excluding, for clarity,[*],
or any treatment of [*] any Indication listed on Exhibit B. 
 1.144 “Retained Field Product” has the
meaning set forth in Section 2.7. 
 1.145 “Royalty Term” has the meaning set forth in
Section 8.4(b). 
 1.146 “Royalty Territory” means, for a particular Product: (a) no countries or
jurisdictions of the world so long as Portola has not exercised its Opt-Out Option for such Product; and (b) all countries and jurisdictions of the world if and only if Portola exercises its Opt-Out Option for such Product. 

1.147 “Sales & Royalty Report” has the meaning set forth in the Financial Exhibit. 

1.148 “Sales Costs” has the meaning set forth in the Financial Exhibit. 

1.149 “Sales Returns & Allowances” has the meaning set forth in the Financial Exhibit. 

1.150 “[*] Patents” shall mean (i) the patents and patent applications set forth on Exhibit E (together with
all divisionals, continuations, substitutions, re-examinations, reissues, 

  
 12 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
additions, renewals, revalidations, extensions, registrations, pediatric exclusivity periods and supplemental protection certificates and the like thereof, and any and all foreign equivalents of
the foregoing, and all patents issuing therefrom) and (ii) for all other [*], those and only those [*] that [*] pursuant to [*]. 
 1.151 “Specificity Criteria” means the criteria attached hereto as Exhibit G for determining whether a particular compound constitutes a Syk Selective Inhibitor. 

1.152 “Sublicense Revenue” has the meaning set forth in Section 2.2(b). 

1.153 “Syk” means an enzyme comprised of the amino acid sequence of the spleen tyrosine kinase, including all genetic
variations containing the Syk kinase domain resulting from, for example, nucleotide mutations, alternative splicing, and fusions with other genes, as well as including all variants of Syk resulting from post-translational modification. 

1.154 “Syk Selective Inhibitor” means any pharmaceutical agent that meets the Specificity Criteria. 

1.155 “Term” has the meaning set forth in Section 11.1. 

1.156 “Territory” means the world. 
 1.157 “Third Party” means any Person other than a Party or an Affiliate of a Party. 
 1.158 “Transition Date” has the meaning set forth in Section 5.1(a). 
 1.159 “Transition Plan” has the meaning set forth in Section 4.1(b). 
 1.160 “United States” or “US” means the United States of America, including its territories and possessions. 

1.161 “Valid Claim” means, with respect to any country, a claim of: (a) an issued and unexpired patent (as may be
extended through supplementary protection certificate or patent term extension or the like) in such country provided that any such patent has not been revoked, held invalid or unenforceable by a patent office, court or other governmental agency of
competent jurisdiction in a final and non-appealable judgment (or judgment from which no appeal was taken within the allowable time period), provided that such claim has not been disclaimed, denied or admitted to be invalid or unenforceable through
reissue, re-examination or disclaimer or otherwise; or (b) a pending patent application which has not been revoked, cancelled, withdrawn, held invalid or abandoned and which has not been pending for more than [*] from the date of [*] in such
country, in each case included within Portola Patents, Joint Patents or Biogen Idec Patents. 
 1.162 Interpretation. In
this Agreement, unless otherwise specified: 
 (a) “includes” and “including” shall mean respectively
includes and including without limitation; 

  
 13 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 (b) words denoting the singular shall include the plural and vice versa and words
denoting any gender shall include all genders; 
 (c) words such as “herein”, “hereof”, and
“hereunder” refer to this Agreement as a whole and not merely to the particular provision in which such words appear; and 
 (d) the Exhibits and other attachments form part of the operative provision of this Agreement and references to this Agreement shall include references to the Exhibits and attachments. 

ARTICLE 2 

LICENSE 

2.1 License Grant. 
 (a) Subject to the terms and conditions of this Agreement (including Section 2.3), Portola hereby grants to Biogen Idec an exclusive license which license shall be exclusive even as to
Portola, with the right to grant sublicenses in accordance with Section 2.2, under the Portola Technology and Portola’s interest in the Joint Technology to Develop, make, have made, use, sell, offer for sale and import Products and
Collaboration Compounds, in each case in the Licensed Field in the Territory. For avoidance of doubt, the licenses granted to Biogen Idec under this Agreement shall not include (i) any rights for Biogen Idec to Develop, make, have made, use,
sell, offer for sale or import any other proprietary compound of Portola (whether or not such proprietary compound is licensed by Portola to a Third Party) that is not a Collaboration Compound as an Active Ingredient in any Combination Product with
a Collaboration Compound; or (ii) with respect to any Portola Technology that is [*], such [*] under such Portola Technology to the extent they are beyond the scope of the rights, if any, for such [*] as of the Effective Date or as amended
thereafter consistent with [*]. 
 (b) Subject to the terms and conditions of this Agreement, Biogen Idec hereby grants
to Portola a non-exclusive, non-sublicensable license (but with the right to subcontract in accordance with Section 4.4) in the Territory under Biogen Idec Technology for the sole purpose of performing Portola’s obligations under this
Agreement. 
 (c) Biogen Idec covenants that it shall not sell Collaboration Compound outside of Products to Third
Parties except in support of the Manufacture of Products for which profit-sharing, royalties or Sublicense Revenue, as applicable, shall be paid hereunder for such Products. 
 (d) Portola covenants on behalf of itself and its Affiliates: (i) that it and its Affiliates shall not grant to any Third Party any rights Controlled by Portola or its Affiliates in any Syk
Selective Inhibitors in the Licensed Field during the Term; (ii) that in any licenses granted by Portola or its Affiliates to Third Parties [*] during the Term with respect to [*], such license shall [*]; (iii) to the extent it is
commercially practical to do so, Portola shall [*]; and 

  
 14 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
(iv) that except as approved by Biogen Idec (such approval not to be unreasonably withheld, conditioned or delayed), Portola shall not [*]. 

2.2 Sublicense and Subcontract Rights. 
 (a) Biogen Idec may exercise its rights and perform its obligations under this Agreement by itself or through any of its Affiliates without the prior written consent of Portola. 

(b) Biogen Idec may sublicense the rights granted to it by Portola under this Agreement to one or more Third Parties, [*];
provided, however, [*] or [*] of a Product in a [*] so long as Biogen Idec retains a substantial role in the promotion of such Product in such country. All consideration received by Biogen Idec in the Profit Share
Territory in connection with the grant of such sublicenses, other than (x) reasonable reimbursements for the Development or Manufacturing of Collaboration Compounds or Products by Biogen Idec or (y) amounts received in exchange for Biogen
Idec’s equity (not to exceed the fair market value of such equity) or (z) amounts received in connection with the achievement of a Development Milestone or Regulatory Milestone up to the amount of the corresponding milestone payment paid
by Biogen Idec to Portola under Section 8.2, shall be deemed “Sublicense Revenue”, and such Sublicense Revenue shall be [*] for any Product for which Biogen Idec grants such sublicense [*], and otherwise such Sublicense Revenue
shall be [*]. 
 (c) In performing its obligations and exercising its rights hereunder, each Party may subcontract to
Third Parties the performance of tasks and obligations with respect to the Development, Manufacture and commercialization of Collaboration Compounds and Products as it deems appropriate and without the prior written consent of the other Party,
subject to Sections 4.4, 7.1 and 7.2. Each Party shall remain responsible for its obligations under this Agreement that have been delegated, subcontracted or sublicensed to any of its Affiliates, sublicensees and/or subcontractors. 

2.3 Portola’s Retained Rights. Portola and its Affiliates retain the right under the Portola Technology and Portola’s
interest in the Joint Technology to: (a) exercise its rights and perform its obligations under this Agreement, including the Portola Development Activities, commercialization, Co-Promotion Efforts, and manufacture of Collaboration Compounds and
Products as permitted in Section 6.4; and (b) for any purpose outside the scope of the exclusive license granted to Biogen Idec under Section 2.1(a) subject to the terms and conditions of this Agreement. 

2.4 Exclusivity. 
 (a) [*], neither Party nor any of its Affiliates will directly or indirectly (including by sponsoring work or granting rights to any Third Party) conduct [*] any product comprising a Syk Selective
Inhibitor that is not a Product; provided, however, the provisions of this Section 2.4 shall not apply to (x) any Syk Selective Inhibitor which was [*] (an “Exempted Program”), or (y) any
Syk Selective Inhibitor outside of an Exempted Program which is [*]. 

  
 15 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 (b) In the event that a Party or any of its Affiliates [*] during the Term and if
[*], is engaged, directly or indirectly, in the [*] other than pursuant to an Exempted Program, then immediately upon [*], at such Party’s option in its sole discretion, such [*] (i) shall [*] the terms of this Agreement; or
(ii) shall [*]; or (iii) shall [*]. In the event that (x) a Party [*] pursuant to subsections (ii) or (iii) above, or (y) an Affiliate of such Party [*] to an Exempted Program, Know How and Patent Rights relating to or
covering such [*] (or were derived therefrom, or were otherwise developed [*] Development, Manufacture and/or commercialization [*]) shall [*]. [*], as used in subsection (ii) above, means [*] by a Party such that the Party [*]. 

(c) During the Term, Portola and its Affiliates shall not, directly or indirectly, (i) develop, manufacture, commercialize or
license a Product or Collaboration Compound [*], or (ii) grant any license to, or otherwise permit, a Third Party to conduct any of such activities. 
 2.5 No Implied Licenses; Negative Covenant. Except as set forth herein, Biogen Idec shall not acquire any license or other intellectual property interest, by implication or otherwise, under any
trademarks, Know-How and/or Patent Rights owned or Controlled by Portola. For clarity, the license granted to Biogen Idec under any particular rights in Portola Patent or Portola Know-How shall be exclusive as to any Third Party only to the extent
Portola Controls the exclusive rights to such Portola Patent or Portola Know-How as of the Execution Date or if acquired thereafter the date upon which such rights were acquired. Biogen Idec shall not, and shall not permit any of its Affiliates to,
practice any Portola Patents or proprietary Portola Know-How outside the scope of the license granted to it under Section 2.1(a). Portola shall not, and shall not permit any of its Affiliates to, practice any Biogen Idec Patents or proprietary
Biogen Idec Know-How outside the scope of the license granted to it under Section 2.1(b) or Section 11.5. 
 2.6
Disclosure of Know-How. 
 (a) After the Effective Date and pursuant to the Transition Plan (as defined in
Section 4.1(b)), Portola shall disclose to Biogen Idec the Portola Know-How pertaining to the formulation, Manufacture and Development of the Lead Compound and the Product containing such Lead Compound that is subject to the ongoing Development
by Portola as of the Effective Date. Each Party shall bear its own internal and out-of-pocket costs incurred in connection with such transfer of Portola Know-How under the Transition Plan. 

(b) In addition, as soon as practicable after the Effective Date and as directed by the JSC, Portola shall use Commercially
Reasonable Efforts to disclose to Biogen Idec all material Portola Know-How and other material data, information and documents known to Portola (excluding only such information where a confidentiality obligation to a Third Party precludes such
disclosure and Portola has made reasonable efforts to secure permission from such Third Party to disclose such information to Biogen Idec hereunder) which may be necessary or reasonably useful to Biogen Idec to Develop, Manufacture, or commercialize
the Collaboration Compounds and/or Products. Each Party shall bear its own internal and out-of-pocket costs incurred in connection with such transfer of Portola Know-How. 

  
 16 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 (c) Thereafter, on a continuing basis during the Term: (i) Portola shall
disclose to Biogen Idec additional Portola Know-How and Joint Know-How (to the extent not already known to Biogen Idec) which comes in to existence from time to time, and perform other technology transfer activities as set forth in this Agreement;
and (ii) Biogen Idec shall disclose to Portola the Biogen Idec Know-How (to the extent necessary or reasonably useful for Portola to perform its obligations under this Agreement) and Joint Know-How (to the extent not already known to Portola).
Each Party shall bear its own internal and out-of-pocket costs incurred in connection with such subsequent transfer of Know-How. 
 2.7 Retained Field. Portola shall retain pursuant to Section 2.3 the sole and exclusive right to develop, manufacture and commercialize a Product in the Retained Field (such Product, the
“Retained Field Product”), subject to the following covenant: Portola and its Affiliates shall not during the Term (x) [*], or (y) grant any license to, or otherwise permit, a Third Party to [*]. 

ARTICLE 3 

GOVERNANCE 
 3.1 Alliance Managers. Within thirty (30) days following the Effective Date, each Party will appoint (and notify the other Party of the identity of) a representative having a general
understanding of pharmaceutical Development and commercialization issues to act as its alliance manager under this Agreement (“Alliance Manager”). The Alliance Managers will serve as the contact point between the Parties for the
purpose of providing the Parties with information on the progress of their Development and commercialization activities with respect to the Product(s) and will be primarily responsible for facilitating the flow of information and otherwise promoting
communication, coordination and collaboration between the Parties; providing single point communication for seeking consensus both internally within the respective Party’s organization and together regarding key global strategy and planning
issues, as appropriate, including facilitating review of external corporate communications; and raising cross-Party and/or cross-functional disputes in a timely manner. Each Party may replace its Alliance Manager on written notice to the other
Party. 
 3.2 Joint Steering Committee. 
 (a) The Parties will establish a Joint Steering Committee, composed of three (3) senior executives of Portola and three (3) executives of Biogen Idec, none of which will be an Alliance
Manager. Two (2) of such executives shall be holding a position of vice president or higher; during at least the first year following the Effective Date, each Party’s worldwide head of Research and Development shall be a member of the JSC.
Such JSC members will have Development, commercialization or such other responsibilities within the appointing Party’s organization as appropriate, given the then-current stage of the collaboration contemplated hereunder. Within thirty
(30) days following the Effective Date, each Party will designate its initial members to serve on the JSC and notify the other Party of the dates of availability for the first meeting of the JSC. Each Party may replace its representatives on
the JSC on written notice to the other Party. 

  
 17 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 (b) The JSC will: (i) oversee the collaborative activities of the Parties under
this Agreement; (ii) review and approve the Development Plan (including Development Budget) and the amendments thereto; (iii) determine whether to approve any proposed Niche Indication; (iv) approve each quarterly Reconciliation
Statement in accordance with the Financial Exhibit; (v) determine any matter with respect to which any other joint committee or sub-committee of the Parties created pursuant to this Agreement, including the JDC and the JCC, has been unable to
reach agreement; (vi) consider and act upon such other matters as specified in this Agreement; and (vii) except as set forth herein, consider and act upon such other matters arising in the course of collaborative activities pursuant to
this Agreement but not specified herein. The JSC may delegate any such authority set forth in subsection (ii), (iv), (vi) and (vii) to any subcommittee it establishes under this Agreement, provided that [*] (a “Material
Development Plan Amendment”) shall be subject to the approval of the JSC. 
 (c) The JSC shall not have the
authority to: (i) modify or amend the terms and conditions of this Agreement; (ii) waive either Party’s compliance with the terms and conditions under this Agreement; or (iii) determine any issue in a manner that would conflict
with the terms and conditions of this Agreement. 
 3.3 Meetings of the Joint Steering Committee. 

(a) The JSC shall meet on a quarterly basis and at such other times as the Parties may agree. The first meeting of the JSC shall be
held as soon as reasonably practicable, but in no event later than ninety (90) days following the Effective Date. Meetings shall be held at such dates and places as are mutually agreed or by teleconference or videoconference. 

(b) Each Party may from time to time invite a reasonable number of participants, in addition to its representatives, to attend JSC
meetings in a non-voting capacity, with the consent of the other Party (which shall not be unreasonably withheld); provided, that if either Party intends to have any Third Party (including any consultant) attend such a meeting, such Third
Party will be subject to the prior approval of the other Party and must be bound by confidentiality obligations consistent with the terms of this Agreement. 
 (c) Each Party shall appoint one (1) of its representatives on the JSC to act as co-chairpersons of the JSC. The chairpersons shall set agendas for JSC meetings, provided that the agendas will
include any matter requested by either Party. The chairpersons shall be responsible for recording, preparing and, within a reasonable time, issuing minutes of each JSC meeting, which draft minutes shall be subject to review and approval by the JSC.

 3.4 Decision Making. The JSC shall make decisions unanimously, with each Party’s representatives collectively
having one (1) vote and at least one (1) representative from each Party (other than the Alliance Manager from such Party) participating in such decision. In the event the JSC cannot reach an agreement regarding a decision within the
JSC’s authority for a period of [*] or such shorter time as the Parties may reasonably agree, then the matter shall be referred to the [*] of the Parties for resolution. Such [*] shall use good faith efforts to resolve such matter, including
conducting teleconferences as needed. If such senior executives cannot resolve the matter within [*] or such shorter time as the Parties may reasonably agree, then, [*] shall have the final decision making authority on such matter. When [*] makes a
final 

  
 18 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
determination under this Section 3.4, that final determination, subject to the provisions of Section 3.7: (i) shall be consistent with the terms of this Agreement; (ii) shall
be exercised in a reasonable and good faith manner; (iii) to the extent the matter relates to Development-related decisions, shall not [*] Development of a Product [*] absent commercially reasonable [*]; and (iv) shall not materially
increase the aggregate amount of Development activities to be performed by Portola personnel under the Development Plan without Portola’s prior written consent, [*]. 
 3.5 Sub-Committees; Joint Development Team. 
 (a) The JSC may, at any
time it deems necessary or appropriate, establish and terminate additional joint committees and delegate as many of its responsibilities as it determines appropriate and commercially reasonable to such joint committees. In the absence of any such
joint committees, the JSC shall carry out such duties as are delegated to such other committees hereunder. 
 (b) Without
limiting the foregoing, within thirty (30) days after the Effective Date, the JSC shall establish a Joint Development Team (“JDT”) which shall oversee and direct the Parties’ Development activities with respect to the
Collaboration Compounds and the Products. The Parties intend for the JDT to be an advisory committee and for all decision making authority pertaining to the Development of Collaboration Compounds and Products to reside in the JSC (or committees to
which it delegates any such authority) except as otherwise set forth herein, such as pursuant to Section 3.5(c) or (d) below; it being understood that decisions arising during the day-to-day implementation of the Development Plan shall be
made by the Party responsible under the Development Plan for such implementation so long as such decisions are consistent with the Development Plan. 
 (c) In addition to the JDT, the JSC may establish a JDC as a decision making committee to: (i) oversee the Development of Collaboration Compounds and Products; (ii) review and amend the
Development Plan, provided that Material Development Plan Amendments may, at the request of a Party’s representative on the JDC, be submitted for approval by JSC as set forth in Section 3.2(b); (iii) review, approve and direct
activities relating to the Development of potential Back-Up Compounds and their identification as additional Back-Up Compounds; and (iv) decide whether or not to proceed with Development activities with respect to Product(s) at each Go/No-go
Decision point as set forth in the Development Plan. Prior to the establishment of the JDC, the JSC shall be responsible for all responsibilities allocated to the JDC under this Agreement and shall have the decision making authority on all such
matters set forth in subsections (i) through (iv) above, which decision making authority shall not be delegated by the JSC to the JDT. The JDC, if established, shall be composed of at least three (3) representatives of each Party, two
of which will have responsibility for Development activities within the appointing Party’s organization and one of which shall have responsibility for commercialization activities within the appointing Party’s organization. Decisions of
the JDC shall be made by unanimous vote, with each Party’s representatives to the JDC collectively having one (1) vote and at least one (1) representative from each Party participating in such decision. In the event of a disagreement
among the JDC or the failure of representatives of both Parties to participate in a decision, the matter may be referred to the JSC by a representative of either Party for resolution pursuant to Section 3.4 above. 

  
 19 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 (d) Within thirty (30) days after the Commencement of the first Phase III
Clinical Trial for the first Product, the JSC will establish a Joint Commercialization Committee (“JCC”), which shall oversee and coordinate the Parties’ commercialization and Co-Promotion activities including without
limitation all commercial strategy, pricing and brand strategy for all Products in all indications. Decisions of the JCC shall be made by unanimous vote, with each Party’s representatives to the JCC collectively having one (1) vote and at
least one (1) representative from each Party participating in such decision. In the event of a disagreement among the JCC, the matter shall be referred to the JSC for resolution pursuant to Section 3.4 above. 

3.6 Costs of Governance. The Parties agree that the costs incurred by each Party in connection with its participation at any
meetings under this Article 3 shall be borne solely by such Party. 
 3.7 Discontinuation of Participation on a
Committee. Each committee shall continue to exist until the first to occur of: (a) the Parties by mutual agreement disbanding the committee with the JSC thereafter assuming such committee’s responsibilities or delegating such
responsibilities to a different committee; or (b) Portola providing to Biogen Idec written notice of its intention to disband and no longer participate in such committee, which notice may be given at any time after the [*] anniversary of the
Effective Date. Once Portola has provided such written notice, such committee shall have no further obligations under this Agreement and Biogen Idec shall have the right to solely decide, consistent with the other terms of this Agreement, any
matters previously subject to the review and/or approval by any such committee; provided, however, that Biogen Idec may not materially increase the aggregate amount of Development activities to be performed by Portola
personnel under the Development Plan without Portola’s prior written consent, which consent shall not be unreasonably withheld, conditioned or delayed. 
 ARTICLE 4 
 DEVELOPMENT 

4.1 Development Generally. 
 (a) Development Plan. The Parties’ respective responsibilities for the Development of the Collaboration Compounds and the Products are set forth in this Article 4. As of the Execution Date,
the Parties have agreed upon a Development Plan for the Development of Product(s), attached to this Agreement as Exhibit A. The Development Plan may be revised from time to time by the JDC. Either Party may propose modifications to the
Development Plan for Development of a Product, including clinical trial plans and time lines, and such proposed modifications shall be subject to review and approval by the JDC, provided that with respect to a Material Development Plan Amendment, a
Party may propose such modifications directly to the JSC. Upon approval by the JDC (or JSC, as applicable), such modifications shall become part of the Development Plan. All Development Plans must require periodic reassessment and re-approval (each
a “Go/No-go Decision”) after each clinical trial or at such times as the JDC in its discretion deems appropriate, at which point continuation of relevant Development activities shall be subject to the approval of the JDC in view of
then applicable scientific, clinical, safety, 

  
 20 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
financial and commercial factors. The Development Plan shall allocate Development activities between the Parties, based on the following principles: (i) with respect to Product(s) comprising
the Lead Compound, Portola will be the lead Party for Development activities [*]; (ii) with respect to any Product comprising a Back-Up Compound, Portola will be the lead Party for Development activities until [*] for such Product;
(iii) Portola has the right (but not the obligation) to be the lead Party for Development activities [*]; (iv) Biogen Idec shall be the lead party for [*] for the Products; and (v) Portola shall be the lead Party [*]. The lead Party
for Development activities pertaining to any Product shall have the primary responsibility for the performance of the Development Activities according to the Development Plan and within the Development Budget. In the course of fulfilling its role as
the lead developing Party for a particular Product in a particular Indication and during a particular stage of the Product Development, a Party may request the other Party to conduct certain specific Development activities, and the other Party shall
have the right to accept or reject such request, at its sole discretion. In addition, Biogen Idec will include Portola in Development activities involving scientific leaders and experts worldwide, including participation in advisory board meetings.

 (b) Transition Plan. The Parties have agreed upon a transition plan governing the initial transfer of Portola Know-How
to Biogen Idec, to enable Biogen Idec to perform the Biogen Idec Development Activities with respect to the Lead Compound after the Effective Date under the Development Plan and to assume the role of the lead Development Party and the owner of
Regulatory Filings for the Products containing such Lead Compound in the Major Indications after the Commencement of the first Phase II Clinical Trial for the first such Product in a Major Indication (the “Transition Plan”). Such
Transition Plan is attached to this Agreement as Exhibit H. After the Effective Date, the Parties shall cooperate in good faith to enable a smooth transition under such Transition Plan to minimize the interruption or delay of ongoing
Development activities for the Product. 
 (c) Niche Indications. 

(i) Designation of a Niche Indication. Portola shall have the right but not the obligation to exercise certain rights, as
specified in this Agreement, related to the Development and commercialization of a Product in a certain Indication which is selected from the following list of Indications: (a) [*]; (b) [*]; (c) [*]; (d) [*]; and (e) any
other Indication [*] (the “Niche Indication”). The JSC shall have the right to [*] on the treatment of Products [*] for purposes of [*]. For clarity, absent [*], Portola: (X) will [*]; (Y) will [*]; and (Z) will [*].

 (ii) Initiation of Niche Indication Development. The Development of a Product in the Niche Indication may be
initiated under this Agreement: (A) [*] (the “[*] Niche Development”); or (B) prior to the [*], by Portola [*], if: (x) the Parties [*] for a Product [*]; or (y) the Parties [*] (the “[*]”) for
any Product, in any Major Indication for which [*] has been completed, within [*], (in such case, the “[*] Niche Development”, together with the [*]Niche Development, the “Niche Development”), provided that in each
case of (x) and (y) above, [*]: (1) [*] with respect to such Product; or (2) matters [*]; or any other circumstance [*]. 
 (iii) Biogen Idec [*] for [*] Niche Indications. Biogen Idec shall have the right to [*] the Development of any Product in any [*] Niche Indication (the “Biogen Idec [*]”), by
delivering Portola such notification within [*] after Biogen Idec’s receipt of Portola’s 

  
 21 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
written notice of any [*] Niche Development. In the event Biogen Idec [*] with respect to a Product in a [*] Niche Indication, Portola shall [*] such Product for such Niche Indication. In the
event the JSC decides to further the Development of such Product in the Niche Indication [*], Biogen Idec shall [*]: (A) promptly [*], and, in the event the Parties obtain Regulatory Approval in either the United States or European Union for
such Product in the Niche Indication, promptly [*]; and (B) [*] for such Product in the Niche Indication. 
 (iv) Niche
Indication Development Activities; Development Plan; Decision Making. All Niche Indication Development activities, to the extent not already set forth in the then-current Development Plan, shall become part of such Development Plan, subject to
the JSC’s review, comment and approval, such review, comment and approval not to be unreasonably withheld, delayed or conditioned, it being understood that disapproval or discontinuation of Development of a Product in a Niche Indication upon
bases, including but not limited to, any of (i) a determination that Development of such Niche Indication is [*], (ii) a determination that the Development or commercialization of the Niche Indication would [*] for a Product, and
(iii) [*], shall not [*]. In the event that prior to completion of [*] for such Niche Indication, the JSC cannot agree on: (A) [*] the Development of a Product in a Niche Indication; (B) [*] in connection therewith; or (C) [*]
Development in the Niche Indication, then: (1) in the case of a [*] Niche Development for which [*], then the decision making process on such matter shall [*] for Development matters [*]; or, as the case may be; (2) in the case of a [*]
Niche Development for which [*], and/or in the case of a [*] Niche Development, then the decision making process on such matter shall [*] Chief Executive Officer shall have the final decision making authority on such matter to the extent that it
concerns Development activities [*] for such Niche Indication. In the event [*] Chief Executive Officer exercises its final decision making authority to [*] Niche Development which was initiated pursuant to [*], then [*] shall have the right to [*].
Notwithstanding the foregoing, (I) Portola shall [*] Biogen Idec regarding matters [*] for the Niche Indication and if [*] in the Niche Indication [*], then, Portola shall [*] (a “Niche Indication [*]”); and (II) [*] for
any Niche Indication, Development activities for such Niche Indication shall be [*] for Regulatory Approval with respect to such Niche Indication. 
 (v) Lead Development Party for Niche Indications. Portola shall be the Party leading the Niche Development pursuant to the Development Plan. Portola shall co-lead all communications with Regulatory
Authorities on the Development of such Product with respect to the Niche Indication provided that (x) subject to Section 5.3(a) with respect to Niche Indications, [*] the Regulatory Filings for such Niche Indication [*] for such Niche
Indication; and (y) in all events, [*] for such Niche Indication. Portola may not [*] Develop any Product in a Niche Indication [*]. 
 (vi) Biogen Idec’s Obligations Regarding Niche Indications. In addition to other Development activities assigned to Biogen Idec in the Development Plan with respect to the Niche Indications,
Biogen Idec shall: (A) manufacture all Product for any such Niche Indication, subject to Section 6.4, provided that Biogen Idec shall not be obligated to supply Collaboration Compounds or formulations of Product which are not the subject
of any ongoing clinical Development for a Major Indication; and (B) book all sales worldwide for sales of any Product in any such Niche Indication. 

  
 22 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 (vii) Economic Terms with Respect to Niche Indications. All Development Costs
incurred in connection with the Development of Niche Indication(s) shall be shared by the Parties in the same manner as, and as part of, Development Costs in accordance with Section 4.5, subject to Section 4.1(c)(iii). 

(d) Back-Up Compounds and [*]. Until such time as the JSC determines that [*] derived from [*] the Lead Compound have met the
requirements of the Back-Up Compound Profile or should otherwise [*], Portola shall apply Commercially Reasonable Efforts pursuant to the Development Plan to discover and evaluate Syk Selective Inhibitors which meet the Back-Up Compound Profile,
including but not limited to [*]. At any time after [*] after the Effective Date, the JSC may identify one or more Back-Up Compounds which it has determined [*] (each, a “[*]”) and [*] pursuant to this Agreement. 

(e) Material Transfer. Neither party shall transfer any Collaboration Compound to a Third Party except as approved by the JSC or
otherwise permitted hereunder for purposes of this Agreement. 
 4.2 Portola Development Activities. 

(a) Portola shall use Commercially Reasonable Efforts to timely and diligently conduct all Portola Development Activities assigned
to it in the Development Plan, in accordance with the Development Plan (including any Development Budget included therein) and under the direction of the JSC. 
 (b) For as long as Portola is conducting Portola Development Activities, the status, progress and results of Portola Development activities shall be discussed in reasonable detail at meetings of
the JDC and the JSC. In addition, Portola shall make available to Biogen Idec such information about Portola Development Activities as may be reasonably requested by Biogen Idec from time to time. [*], Portola shall provide Biogen Idec with a
written report on the status, progress and location (including changes of location) of its activities under Section 4.2(a). 
 (c) For as long as Portola is conducting Portola Development Activities, Portola shall permit Biogen Idec’s authorized representatives, during regular business hours: (i) to examine and
inspect Portola’s facilities, and those of its contract research organization used by it in the performance of Portola Development Activities pursuant to the Development Plan; and (ii) subject to applicable laws, to inspect all data,
documentation and work products relating to the activities performed by it. This right to inspect facilities, data, documentation, and work products relating to the Products may be exercised [*] upon [*] advance written notice to Portola.

 (d) Portola shall be responsible for the performance of its Affiliates, sublicensees and/or subcontractors with
respect to the Development, Manufacture, or commercialization of Collaboration Compounds or Products. 
 4.3 Biogen Idec
Development Activities. 
 (a) Biogen Idec shall use Commercially Reasonable Efforts to Develop the Collaboration
Compounds and the Products for at least one Product in each of the Major 

  
 23 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
Territories and in such additional countries in the Territory where it is commercially viable to do so, including timely and diligently conducting all Biogen Idec Development Activities in
accordance with the Development Plan (including the Development Budget) and the direction of the JSC. For clarity, Portola’s Development activities with respect to the Niche Indication(s) for which Biogen Idec has [*] shall not count towards
Biogen Idec’s efforts in determining whether Biogen Idec has met its diligence obligations under this Section 4.3(a). 

(b) For as long as Biogen Idec is conducting Biogen Idec Development Activities, (i) the status, progress and results of
Biogen Idec Development activities shall be discussed in reasonable detail at meetings of the JDC, (ii) Biogen Idec shall make available to Portola such information about Biogen Idec Development Activities as may be reasonably requested by
Portola from time to time, and (iii) [*], Biogen Idec shall provide Portola with a written report on the status, progress and location (including changes of location) of its activities under Section 4.3(a), [*]. 

(c) For as long as Biogen Idec is conducting Biogen Idec Development Activities and Portola has not exercised its Opt-Out Option
with respect to the applicable Product, Biogen Idec shall permit Portola’s authorized representatives, during regular business hours: (i) to examine and inspect Biogen Idec’s facilities, and those of its contract research organization
used by it in the performance of Biogen Idec Development Activities pursuant to the Development Plan with respect to such Product; and (ii) subject to applicable laws, to inspect all data, documentation and work products relating to the
activities performed by it. This right to inspect facilities, data, documentation, and work products relating to the Products may be exercised [*] upon [*] advance written notice to Biogen Idec. 

(d) Biogen Idec shall be responsible for the performance of its Affiliates, sublicensees and/or subcontractors with respect to the
Development, Manufacture, or commercialization of Collaboration Compounds or Products. 
 4.4 Compliance. Each Party
agrees that in performing its obligations under this Agreement: (a) it shall comply with all applicable laws, regulations and requirements, including without limitation, generally accepted standards of good clinical practice; and (b) it
will not employ or engage any Person who has been debarred by any Regulatory Authority, or, to such Party’s knowledge, is the subject of debarment proceedings by a Regulatory Authority. Each Party shall cause any permitted subcontractor(s)
engaged by it in connection with the performance of any Development activities to be bound by written obligations of confidentiality and invention assignment consistent with those contained herein, and such Party remains primarily responsible for
the performance of such subcontractor(s). 
 4.5 Development Expenses. 

(a) Subject to Section 4.5(b), all Development Expenses incurred by the Parties under the Development Plan in the Territory
shall be shared between the Parties at a ratio of 75:25 (Biogen Idec:Portola) as determined according to the provisions of the Financial Exhibit. 

  
 24 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 (b) On a Product-by-Product basis, Portola shall have the option (the
“Opt-Out Option”) to opt-out of its co-funding of the Development of such Product under this Section 4.5, which option shall be exercisable by providing Biogen Idec with written notice within [*] after the earlier of either:
(i) [*]; or (ii) receiving from Biogen Idec [*]. Upon Portola’s exercise of the Opt-Out Option notwithstanding anything herein to the contrary: (A) Portola’s obligation to share Development Expenses for such Product under
this Section 4.5 [*] and the Parties shall [*] between the Parties [*]; (B) subject to Section 11.4, Biogen Idec shall thereafter [*] after such date; (C) for as long as Portola continues to conduct Portola Development Activities
for such Product under the Development Plan, Portola [*] for such Product [*]; (D) Portola shall[*] but shall [*]; (E) notwithstanding Article 3, each of the JSC and JDC shall meet on [*] basis (or more frequently as the Parties otherwise
agree) until [*], thereafter all committees, including the JSC, JDC, and if applicable the JCC, shall disband and the consequence set forth in Section 3.7 shall apply; provided, however, that (x) if [*], all
committees, including the JSC, JDC and JCC shall immediately be disbanded and the consequence set forth in Section 3.7 shall apply; and (y) if[*] for which Portola has [*], the provisions of this subsection (E) shall not apply unless
and until [*]; (F) notwithstanding Section 3.4, while the JSC is still in place, in the event the Parties’ representatives on the JSC cannot agree on a matter,[*] representative at the JSC shall have the right to make the final
decision on such matter without the need for further escalation; (G) Portola [*] with respect to such Product [*]; (H) Portola shall retain the commercialization rights set forth in Section 7.2(b) [*] with respect to [*], provided
that if [*], such commercialization rights under Section 7.2(b) [*]; and provided, further that, the Parties [*] related to the Development and commercialization of the Products, including Product containing Back-Up Compounds, such as [*];
provided that in such event, the Parties [*] between the Parties [*], and provided, further, that if [*], all such rights of involvement [*]. 
 ARTICLE 5 
 Regulatory 

5.1 Transition to Biogen Idec. 
 (a) Portola shall make and own all Regulatory Filings and all documents related to Regulatory Filings for the Product prior to the earlier of (x) [*], and (y) [*] (the “Transition
Date”). Within [*] after the Transition Date or on such later date as provided under Section 5.3, Portola shall transfer to Biogen Idec or its designee all Regulatory Filings, as well as all safety and clinical databases, statistical
databases, bioanalytical data, biosample repositories, and all information supporting such Regulatory Filings (“Regulatory Materials”) and all electronic documents related to all such Regulatory Materials, so that, subject to
Section 5.3, Biogen Idec shall become the exclusive owner of all Regulatory Filings and other Regulatory Materials related to the Collaboration Compounds and/or Products. The Parties shall cooperate and facilitate such transfer in an efficient
manner so as not to delay the timeline for the Development of the Product. 
 (b) As soon as is reasonably practical
after the Effective Date, Portola shall provide Biogen Idec with electronic copies of (i) all INDs relating to the Collaboration Compounds or Product, including all Regulatory Filings submitted to FDA in connection with

  
 25 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
such INDs and all associated correspondence, (ii) any regulatory filings submitted to any Regulatory Authority outside of the United States relating to the Collaboration Compounds or Product
and all associated correspondence; and (iii) any other Regulatory Materials pertaining to the Products. 
 5.2
Regulatory Responsibilities. After the Transition Date: 
 (a) Biogen Idec shall own and submit all Regulatory
Filings and substantial documents related to Regulatory Filings for the Development of the Products, including, but not limited to, any Phase III Clinical Trials for the Products, except as Section 5.3 provides to the contrary with respect to
Products for the Niche Indication; 
 (b) Biogen Idec shall keep Portola informed, via participation on the JDC, of
regulatory developments specific to Collaboration Compounds and Product throughout the Territory. The JDC shall discuss regulatory matters relating to Collaboration Compound and Product and, Portola, through participation on the JDC, shall have the
right to contribute to the regulatory plans and strategies; 
 (c) Biogen Idec shall, within two (2) Business Days,
provide to Portola copies of all major submissions to the FDA and/or EMA, and all key communications between Biogen Idec and (or its Affiliates) and the FDA and/or EMA, regarding the Collaboration Compounds and/or Products; and 

(d) Biogen Idec will lead discussions with any Regulatory Authority related to any Development of any Collaboration Compounds or
Products. To the extent permitted by FDA and/or EMA, Portola shall have the right, but not the obligation, to send one (but no more than three) attendee(s) to participate in any significant meeting between Biogen Idec and the FDA and/or EMA
primarily related to any Collaboration Compound and/or Product that occurs: (i) prior to the Regulatory Approval for such Product in the applicable jurisdiction; or (ii) after such Regulatory Approval only when such meeting pertains to
[*]. 
 5.3 Regulatory Matters Prior to Transition Date and for Niche Indications. Notwithstanding the foregoing, the
Parties agree that: 
 (a) Portola shall be the Party filing, owning and holding any Regulatory Filing: (i) for the
Product for all Indications prior to the Transition Date; and (ii) for Niche Indications arising under a [*] Niche Development after the Transition Date until the earliest of (x) [*] in such Niche Indication, (y) [*], and
(z) Development of the Lead Compound [*], whereupon Portola shall transfer such Regulatory Filings to Biogen Idec; provided, however, (A) if a human clinical trial is pending at such time for such Niche
Indication, such transfer shall not occur until the completion of such trial, and (B) that in all events, [*]. 
 (b)
Portola shall keep Biogen Idec informed, via participation on the JDC and prompt delivery to Biogen Idec of all submissions to, draft submissions, and all communications with the Regulatory Authorities, of regulatory developments specific to
Collaboration Compounds and Product for which Portola is the holder of such Regulatory Filings. The JDC shall discuss any regulatory matters under such Regulatory Filings and Biogen Idec, 

  
 26 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
through participation on the JDC and otherwise, shall have the right to direct regulatory plans and strategies therefor; 
 (c) Portola shall, within two (2) Business Days, provide to Biogen Idec copies of all submissions to the FDA and/or EMA, and all communications between Portola and (or its Affiliates) and the
FDA and/or EMA, regarding the Collaboration Compounds and/or Products prior to the Transition Date for all Indications and thereafter for Niche Indications; and 
 (d) Portola will lead discussions with any Regulatory Authority related to any Development of any Collaboration Compounds or Products prior to the Transition Date in all Indications, and will [*]
such discussions after the Transition Date for all Niche Indications. To the extent permitted by FDA and/or EMA, Biogen Idec shall have the right (but not the obligation) to attend and participate in any significant meeting between Portola and the
FDA and/or EMA related to any Collaboration Compound and/or Product for [*]. 
 ARTICLE 6 

Manufacturing 
 6.1 Supply for Clinical Trials. 
 (a) Initial Supply. Portola shall
procure the Collaboration Compounds and Products for use in the Development of Collaboration Compounds and Products (including procuring adequate clinical supply for the conduct of the first Phase II Clinical Trial) until the later of the
(x) Transition Date, (y) in the event Biogen Idec decides to [*], and (z) such later date as the Parties may mutually agree, with such Manufacturing activities to be conducted by Portola as set forth in the Development Plan (the
“Portola Manufacturing Activities”). All Materials (and all other research materials related to Collaboration Compounds) which are owned by or otherwise in the possession or control of Portola as of the Effective Date shall be
contributed to the collaboration for use pursuant to this Agreement [*]. All expenses incurred by or on behalf of Portola in connection with Portola Manufacturing Activities after the Execution Date that would otherwise fit within the definition of
“Development Expenses,” shall be Development Expenses. 
 (b) Biogen Idec Supply. Except for the Portola
Manufacturing Activities and subject to Section 6.4, Biogen Idec shall be responsible for the Manufacture and supply of Collaboration Compounds and Products used in all non-clinical and clinical studies under this Agreement (including for the
Development of the Product in Niche Indications). As provided in Section 6.2 below, the Parties shall cooperate so that the transfer of the Portola Manufacturing Know-How occurs in a timely manner in order to enable Biogen Idec to Manufacture
Collaboration Compounds and Products. 
 6.2 Portola’s Transfer of Portola Manufacturing Know-How to Biogen Idec.
The Parties desire that Biogen Idec be able to commence the Manufacture of Product (including Collaboration Compounds) as soon as practicable after the Transition Date. To enable Biogen Idec to commence Manufacture of Product (including
Collaboration Compounds) Portola shall perform technology transfer to Biogen Idec as set forth below: 

  
 27 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 (a) during a period of [*] following the Effective Date (the “Manufacturing
Transfer Period”), make available and transfer to Biogen Idec copies of the Portola Technology that are necessary or useful in the Manufacture of Product and as of such date are being used by Portola, its Affiliates or its Contract
Manufacturers to Manufacture Product, including but not limited to batch record summaries (the “Portola Manufacturing Know-How”) solely for Biogen Idec, its Affiliates, its sublicensees or Contract Manufacturers to Manufacture or
have Manufactured Product and/or Collaboration Compounds after the Transition Date; 
 (b) during the Manufacturing
Transfer Period, when requested by Biogen Idec make available to Biogen Idec, its Affiliates or Contract Manufacturers a reasonable number of appropriately trained personnel to provide, on a mutually convenient timetable, technical assistance (both
on site and otherwise) reasonably sufficient for the effective and efficient transfer and demonstration of the Portola Manufacturing Know-How that is necessary or useful to Manufacture Collaboration Compounds and Products. After the Manufacturing
Transfer Period, if requested by Biogen Idec, Portola will in good faith endeavor to provide additional technical assistance in the transfer of Portola Manufacturing Know-How to Biogen Idec, it being acknowledged that once the Manufacturing Transfer
Period has ended, Portola’s resources in providing such transfer of Portola Manufacturing Know-How may be limited; 

(c) during the Manufacturing Transfer Period, use commercially reasonable efforts to promptly assist Biogen Idec in obtaining all
necessary Regulatory Approvals and/or modify existing Regulatory Approvals for the Manufacture by Biogen Idec, its Affiliates or their Contract Manufacturers of Product for use by Biogen Idec in the Territory; 

(d) allow Biogen Idec, its Affiliates or their Contract Manufacturers to cross reference Portola or its suppliers or Contract
Manufacturers’ DMF or such other regulatory submissions controlled by Portola applicable to the Materials, or Product, as the case may be, if any; 
 (e) provide Biogen Idec with information with respect to Collaboration Compound or Product or the Materials used in their Manufacture to the extent necessary or useful for registering Biogen
Idec’s selected facility as an approved Manufacturing site for Product or Collaboration Compounds and to otherwise enable Biogen Idec to expeditiously as possible commence the Manufacture of Product; 

(f) at Biogen Idec’s request during the Manufacturing Period, use Commercially Reasonable Efforts to assist Biogen Idec in
entering into supply agreements with Portola’s current Contract Manufacturers for the purchase of Collaboration Compounds and Products; and 
 (g) Biogen Idec and Portola shall enter into a Quality Agreement promptly after the Effective Date with respect to the activities contemplated with respect to transfer of Manufacturing Know-How and
the Manufacturing of the Products by the Parties. 
 6.3 Commercial Supply. Biogen Idec shall be solely responsible for
the Manufacture of Collaboration Compounds and Products for commercial supply, subject to Section 6.4. After the Manufacturing Transfer Period, Biogen Idec shall apply Commercially 

  
 28 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
Reasonable Efforts to develop sources of supply to obtain adequate amounts of Collaboration Compounds and Products for the conduct of the Development and commercialization activities contemplated
under the then current Development Plan and Commercialization Plan. 
 6.4 Portola’s Right to Manufacture.

 (a) In the event that Biogen Idec, as the Party responsible for the Manufacture and supply of Collaboration
Compound and Products under Sections 6.1(b) and 6.3, is unable to meet such supply responsibility for any period greater than [*] during the Term (other than circumstances outside of its control or due to Force Majeure), either by itself or
through a Contract Manufacturer, and Biogen Idec is not engaged in Commercially Reasonable Efforts to correct such situation, then, for only so long as such situation persists (provided that Portola shall be allowed to wind down any manufacturing
activities in an orderly fashion thereafter), Portola shall have the right to Manufacture and supply such Collaboration Compound and Products; provided that [*]. In addition, if [*], Biogen Idec may elect not to Manufacture and supply
Collaboration Compound and Product [*], in which case Biogen Idec shall give Portola notice of its intent not to manufacture [*] at least [*] prior to the date [*] and Portola shall have the right to Manufacture and supply such
Collaboration Compound and Products [*]. If Portola has the right to Manufacture and supply the Collaboration Compound and Products, Biogen Idec shall assist Portola to establish a direct relationship with Biogen Idec’s Contract
Manufacturers for such Collaboration Compound and Product and perform any technology transfer to Portola and its Contract Manufacturer to enable Portola’s assumption of such responsibility in the same manner as set forth in Section 6.2,
mutatis mutandis. 
 (b) In addition, if Portola exercises its Niche Commercialization Option pursuant to
Section 7.2(a)(i), then, within [*] after Portola’s exercise of such option, Biogen Idec shall inform Portola in writing as to whether it will Manufacture and supply such Product or Active Pharmaceutical Ingredient for the Niche Indication
for commercial use, after which: (a) in the event Biogen Idec [*] will Manufacture and supply such Product (or Active Pharmaceutical Ingredient) for the Niche Indication for commercial use, then Biogen Idec shall [*], and shall cooperate with
Portola in doing so; or (b) in the event Biogen Idec [*] will not Manufacture and supply such Product (or Active Pharmaceutical Ingredient) for the Niche Indication for commercial use, then Portola shall [*], provided that Biogen Idec shall:
(i) at Portola’s request, assist Portola to establish a direct relationship with Biogen Idec’s Contract Manufacturers responsible for the Manufacture of such Product; and (ii) continue to Manufacture and supply the Product at
Portola’s request until Portola is able to Manufacture and supply such Product by itself or through its Contract Manufacturers. 
 (c) Portola shall have the right to manufacture [*] and [*], if any, for use in the Retained Field. 
 6.5 Manufacturing Costs and Related Costs. 
 (a) Costs and expenses
associated with the transfer of the Portola Manufacturing Know-How under Section 6.2 shall be borne in the same manner as the Development Expenses, in accordance with Section 4.5. 

  
 29 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 (b) Manufacturing costs for Collaboration Compounds and Products used in a particular
study or clinical trial shall be included in the Development Expenses for such study or clinical trial. For clarity, Manufacturing Costs shall not [*]. 
 (c) Manufacturing costs for Collaboration Compounds and Products for the commercialization of the Products in the Profit Share Territory shall: (a) be included as part of the Cost of Sales if
Portola does not exercise its Opt-Out Option for such Product; or, as the case may be, (b) borne solely by Biogen Idec to the extent incurred after Portola exercises its Opt-Out Option for such Product. 

(d) Manufacturing costs for Collaboration Compounds and Products for the commercialization of the Products in the Royalty
Territory shall be borne solely by Biogen Idec. 
 (e) Manufacturing costs for Collaboration Compound for use in the
Retained Field shall be borne solely by Portola. 
 6.6 Manufactured Products. Each Party represents and warrants that
all Products used in clinical trials and/or for commercial use that are Manufactured or procured by such Party shall: (a) meet the applicable specifications; (b) be Manufactured in accordance with cGMPs; and (c) be Manufactured in
accordance with all applicable laws and regulations and Regulatory Authority requirements then in effect. 
 ARTICLE 7

 COMMERCIALIZATION 
 7.1 Commercialization. 
 (a) Subject to Portola’s right under
Section 7.2 to elect either to: (i) lead certain commercialization efforts for the Products in the Niche Indication(s) in the U.S. as set forth herein; or (ii) Co-Promote one or more of the Product(s) in the U.S. after Portola’s
exercise of its Co-Promotion Option, Biogen Idec will be responsible for commercialization of the Products throughout the Territory, and shall use Commercially Reasonable Efforts to commercialize at least one Product in each of the Major
Territories, as well as in such countries in the rest of the Territory where it is commercially viable to do so, all in accordance with a Commercialization Plan (including its associated budget) to be reviewed and approved by the JCC within [*]
after the Commencement of the first Phase III Clinical Trial for the first Product in the first Indication. 
 (b) The
Parties acknowledge that prior to the Effective Date, Portola has been conducting activities with scientific leaders and experts in connection with the Development of the Collaboration Compound. Upon the Effective Date, all decisions relating to
activities with scientific leaders and experts on data and results relating to the Collaboration Compounds and/or Products, including Portola’s on-going activities in that respect, shall be [*]. In addition, Biogen Idec will make reasonable
efforts to include Portola in global commercialization activities involving scientific leaders and experts, including participation in advisory board meetings. In the event Portola elects to lead the commercialization of the Product in the Niche
Indications 

  
 30 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
pursuant to Section 7.2(a), Portola will have the right to conduct activities with scientific leaders and experts in connection with the Development of the Collaboration Compound in the
Niche Indication, and in doing so, make reasonable efforts to include Biogen Idec in commercialization activities involving scientific leaders and experts, including participation in advisory board meetings. 

(c) The Parties shall carry out their respective commercialization activities for the Products in the Territory in the Licensed
Field in accordance with a commercialization plan, to be prepared by the JCC and subject to the approval by the JSC (and if the JCC is not established, such plan shall be prepared and approved by the JSC) (the “Commercialization
Plan”). The Commercialization Plan shall set forth the Parties’ respective activities and responsibilities for the commercialization of the Products in the Major Indications and any Niche Indications, from the preparation of Product
launch, launch to post-launch activities. The Commercialization Plan shall also set forth the Commercialization Budget, subject to the approval of the JSC, and the projected sales volume of such Product. The Commercialization Plan and the
Commercialization Budget may be amended by the JCC; provided that amendments to the Commercialization Budget constituting an increase in costs of greater than [*] shall be subject to the approval of the JSC. 

7.2 Portola Commercialization and Co-Promotion Rights. Subject to Section 4.5, Portola shall have the certain
commercialization and Co-Promotion right as set forth below. Notwithstanding anything to the contrary in this Section 7.2, however, Portola may [*], and Portola may [*]. 
 (a) Portola’s Right to Lead Commercialization of Niche Indications in the United States. 
 (i) In the event Portola exercises its right to Develop a Niche Indication under this Agreement, then Portola shall have the right, but not the obligation, to be the lead commercialization Party
for certain activities for such Niche Indication in the United States by being the Party leading the efforts on, and making decisions with respect to: (A) [*]; (B) [*]; (C) [*]; and (D) [*] (the “Niche Commercialization
Option”). Portola shall notify Biogen Idec as to whether it desires to exercise the Niche Commercialization Option for the Niche Indications within [*] after the [*]. In the event Portola decides not to exercise the Niche
Commercialization Option for the Niche Indications, then Biogen Idec shall be the Party responsible for the commercialization of the Product in the Niche Indications as if they are Major Indications, and Section 7.2(b) shall apply to the Niche
Indications in the same manner as they apply to Major Indications except that under such circumstance Portola shall not have a Co-Promotion Option with respect to such Niche Indication. In all events, Biogen Idec shall retain responsibility for all
commercialization activities for such Niche Indication Products which are not allocated to Portola [*], including [*]. 

(ii) In the event Portola exercises the Niche Commercialization Option for a Product for the Niche Indication in the U.S. and
[*], then Biogen Idec shall have the right to Co-Promote each Product during the co-promotion term (the “Biogen Idec Co-Promotion Term”) for such Product in the applicable Niche Indication in which Regulatory Approval is
obtained for such Product, under the same terms and conditions as set forth in Section 7.2(b)(i) through (v) (including the terms set forth in Exhibit I), applied mutatis mutandis, provided that Biogen Idec’s Co-Promotional
Efforts shall be up to [*] in such Niche Indication. 

  
 31 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 (iii) For clarity, Biogen Idec shall be the lead commercialization Party for the
Products in Niche Indications outside the U.S. 
 (b) Portola’s Right to Co-Promote in the Major Indications in the
United States. 
 (i) Subject to Section 4.5, Portola shall have the right to Co-Promote each Product, in
accordance with the rest of this Section 7.2(b). 
 (ii) Portola shall have the right to elect to Co-Promote each
Product in the United States (the “Co-Promotion Option”) during the co-promotion term for such Product (the “Portola Co-Promotion Term”) following an NDA filing for such Product in the U.S. as more specifically set
forth herein. Within [*] after an NDA filing for such Product with the FDA, Biogen Idec will notify Portola of Biogen Idec’s preliminary estimate of the Details it anticipates for such Product in the United States to healthcare professionals
(the “Biogen Idec Estimate”). The Portola Co-Promotion Option may be exercised by Portola with respect to a particular Product for any [*] Major Indications only if (W) [*], (X) [*] for any Niche Indication,
(Y) Portola has [*], and (Z) Portola gives Biogen Idec written notice of such exercise no later than [*] after the later of (u) receipt of the Biogen Idec Estimate, and (v) the first date on which conditions (W)-(Y) apply on
or after the date of the delivery of the applicable Biogen Idec Estimate. Portola may exercise the Co-Promotion Option with respect to a particular Product [*] by written notice to Biogen Idec no later than [*] after the receipt of the Biogen Idec
Estimate for such Product. For clarity, all Portola Co-Promotion Terms for [*] Major Indications shall cease upon [*], subject to an orderly wind-down of not more than [*] with respect to any ongoing co-promotion activities. 

(iii) The promotion efforts of Portola for such Product (the “Portola Co-Promotion Effort”) shall be up to
[*] of the total Detailing effort for Products, subject to variation from time to time upon [*] written notification from Portola to Biogen Idec, provided that: (A) Portola’s Co-Promotion Efforts shall [*], unless Portola
terminates the Portola Co-Promotion Term in accordance with subsection (iv) below; and (B) Portola shall inform Biogen Idec of its desired initial Co-Promotion Efforts concurrent with its written notification to exercise the Portola
Co-Promotion Option. 
 (iv) The Portola Co-Promotion Term with respect to a particular Product shall continue for as
long as such Product is being sold, unless Portola provides Biogen Idec with a [*] written notice of its decision to relinquish its Co-Promotion Efforts with respect to such Product, in which case Biogen Idec and Portola shall reasonably
cooperate to transition to Biogen Idec all of Portola’s co-promotion activities with respect to such Product so as to minimize disruption to sales activity and Portola shall withdraw its sales representatives from such co-promotion activities
in a professional manner. 
 (v) If Portola initiates the Portola Co-Promotion Term for a Product, Portola shall have
the right to Co-Promote such Product in the U.S. by providing sales calls to 

  
 32 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
healthcare professionals in geographically dispersed population centers in the United States with a pro-rata allocation of high volume Prescribers and academic centers of excellence based on the
Portola Co-Promotion Efforts. 
 (vi) Promptly after Portola exercises such Portola Co-Promotion Term for the first
Product, Biogen Idec and Portola shall commence negotiations in good faith and enter into a co-promotion agreement (the “Co-Promotion Agreement”) in accordance with the terms and conditions set forth in Exhibit I attached
hereto. The Parties shall use Commercially Reasonable Efforts to enter into and execute the Co-Promotion Agreement within [*] following Portola’s initiation of the Co-Promotion Term. 

(vii) For clarity, for all Indications, regardless of Portola’s Co-Promotion Efforts, Biogen Idec shall retain all
decision-making authority related to Product recalls and withdrawals, and pricing and commercial terms, and Biogen Idec shall book all sales (including invoicing, collections and other supply chain activities) for the Products under this Agreement.
For clarity, regardless of Portola’s Co-Promotion Efforts, Biogen Idec shall retain all decision-making authority related to all commercialization activities and plans, including but not limited to medical affairs and medical education, for all
Products in the Major Indications. 
 7.3 Product Recalls. In the event that any Regulatory Authority issues or requests
a recall or takes similar action in connection with a Product, or in the event a Party reasonably believes that an event, incident or circumstance has occurred that may result in the need for a voluntary or mandatory recall, market withdrawal or
other corrective action regarding a Product, such Party shall promptly advise the other Party (in the case of Portola, the Chief Executive Officer or another senior executive designated in advance by the Chief Executive Officer; and in the case of
Biogen Idec, the Senior Vice President of Quality or other appropriate senior representative) thereof by telephone or facsimile. Biogen Idec shall decide and have control of whether to conduct a recall or market withdrawal (except in the event of a
recall or market withdrawal mandated by a Regulatory Authority, in which case it shall be required) or to take other corrective action in any country and the manner in which any such recall, market withdrawal or corrective action shall be conducted;
provided that the Biogen Idec shall notify Portola prior to making any public disclosure of the recall, market withdrawal or corrective action and shall keep Portola regularly informed regarding any such recall, market withdrawal or corrective
action. Recall costs shall be borne by the Parties consistent with the cost sharing formula set forth in Section 8.3; provided, however, Biogen Idec shall bear the costs incurred by the Parties in connection with any
recall in the Royalty Territory. 
 7.4 Pharmacovigilance. 

(a) Biogen Idec shall own the global safety databases for all Products. 

(b) Without limiting the foregoing, with respect to clinical trials being carried out by or on behalf of Biogen Idec, each Party
agrees prior to commercialization pursuant to this Agreement, during the Term hereof, to notify the other Party within [*], in English, of any information of which the first Party becomes aware concerning any serious side effect, injury, toxicity or
sensitivity reaction, or any unexpected incident, whether or not determined to be attributable to any Product (hereinafter “Serious Adverse Experience”), where such Adverse 

  
 33 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
Experience is life threatening and associated with the clinical uses, studies, investigations and tests of Product. With respect to all other Adverse Experiences (non-life threatening), the Party
first learning of such experience shall furnish the other Party with copies of such Adverse Experiences reported to it, in English, within [*] after receipt. “Life threatening” as used in this Section refers to an experience which
results in death, is immediately life-threatening, results in persistent and significant disability/incapacity or requires in-patient hospitalization or prolongation of existing hospitalization, or is an overdose. Other important medical events that
may jeopardize the patient or may require intervention to prevent one of the outcomes previously listed should also be considered serious. “Unexpected” as used in this Section refers to a condition or development not listed in the
current labeling or investigator’s brochure for Product, and includes an event that may be symptomatically and pathophysiologically related to an event listed in the labeling, but differs from the event because of increased frequency or greater
severity or specificity. 
 (c) Notwithstanding the provisions of Section 7.4(b), with respect to clinical trials
being carried out by or on behalf of Portola, Portola shall provide Biogen Idec with Serious Adverse Experience reports of unexpected life threatening events which are possibly, probably, definitely related or of unknown relationship to the use of
Product within [*] after receipt of the information. Portola shall also provide Biogen Idec with Serious Adverse Experience reports of unexpected non-life threatening events which are possibly, probably, definitely related or of unknown relationship
to the use of Product within [*] after receipt of the information. In addition, Portola shall furnish to Biogen Idec copies of the end of study summary of Adverse Experiences in English within the time period set forth in the applicable then-current
clinical development plan for Product. 
 (d) Portola shall provide Biogen Idec with all legacy serious Adverse
Experience data from all previously conducted Portola sponsored trials prior to execution of the safety data exchange agreement. 
 (e) By no later than [*] following the Effective Date, the Parties shall agree upon and implement a formal procedure for the mutual exchange of adverse event reports and safety information
associated with the Product. Details of the operating procedure respecting such adverse event reports and safety information exchange shall be the subject of a mutually-agreed pharmacovigilance agreement between the Parties. Such pharmacovigilance
agreement shall be implemented at a time sufficient to permit compliance, and shall supersede Sections 7.4(b) through (d). If the Parties enter into a Co-Promotion Agreement pursuant to the provisions set forth in Section 7.2 above, any
such Co-Promotion Agreement shall specify a reporting procedure for Portola to report to Biogen Idec any adverse events related to the use of the Product. Biogen Idec shall be solely responsible for reporting to the FDA (and other Regulatory
Authorities as applicable) adverse events and complaints relating to the Products and for maintaining a database of such adverse events and complaints. 

  
 34 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 ARTICLE 8 
 FINANCIAL PROVISIONS 
 8.1 Upfront Payment and Investment.

 (a) Biogen Idec shall pay to Portola a one-time, non-refundable, non-creditable upfront payment of thirty-six
million dollars (US $36,000,000) within [*] after the Effective Date. 
 (b) Concurrent with the execution of this
Agreement, the Parties has entered into that certain Stock Purchase Agreement of even date hereof, pursuant to which Biogen Idec has agreed to purchase nine million dollars (US $9 million) worth of Series 1 Preferred Stock of Portola.

 8.2 Milestone Payments. 
 (a) Lead Compound. Subject to the terms and conditions of this Agreement (including the rest of this Section 8.2), Biogen Idec shall pay to Portola the milestone payments set forth below upon
(i) [*][*] or [*][*]; or (ii) with respect to [*][*], [*][*] or [*][*]: 
  

			
	 Milestone
	  	 Milestone Payment

	 Development Milestones

	 [*]
	  	$[*]
	 [*]
 [*]

	 [*]
	  	$[*]
	 [*]
	  	
	 [*]
	  	$[*];
	 [*]
	  	$[*];
	 [*]
	  	$[*]; and
	 [*]
	  	$[*].
	 [*]
	  	
	 [*]
	  	
	[*]

  
 35 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

			
	 Milestone
	  	 Milestone Payment

	 Milestone
	  	 Milestone Payment

	 [*]
	  	$[*]
	 [*]
	  	$[*]
	 [*]
	  	$[*]
	 [*]
	  	$[*]
	 [*]

		
	 Milestone
	  	 Milestone Payment

	 [*]
	  	$[*]
	 [*]
	  	$[*]
	 [*]
	  	$[*]
	 [*]
	  	$[*]
	 [*]
	  	$[*]
	 [*]
	  	$[*]

 (b) Back-Up Compound. Subject to the terms and conditions of this Agreement (including the rest of
this Section 8.2), Biogen Idec shall pay to Portola the milestone payments set forth below [*][*] or [*][*]: 
  

			
	 Milestone
	  	 Milestone Payment

	 Development Milestones

	 [*]
	  	$[*]
	 [*]
	  	$[*]
	 [*]
	  	$[*]
	 [*]
	  	$[*]
	 [*]
	  	$[*]
	 Regulatory Milestones

	 [*]
	  	$[*]
	 [*]
	  	$[*]
	 [*]
	  	$[*]
	 [*]
	  	$[*]

  
 36 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 If Biogen Idec [*] for a Collaboration Compound, such Collaboration Compound shall be deemed to [*]
as of such [*] with respect to the timing of this Section 8.2(b), even if [*]. 
 (c) Biogen Idec shall
notify Portola in writing within [*] following the achievement of each milestone event, and shall make the appropriate milestone payment within [*] after the achievement of such milestone event. 

(d) The milestone payments set forth in Sections 8.2(a) and (b) above shall be payable [*] achievement of such milestone
and [*] for [*] achievement of such milestone and shall [*] for [*] or [*] or [*] that was [*] for the [*], provided that such milestone [*] for the [*] or [*]. For clarity, [*] milestone shall be payable with respect to a Product which is a [*] and
[*]. 
 (e) The milestone payment triggered by [*] shall become due and payable upon [*] for the [*] if
such [*] at such time. The achievement of a milestone event (the “Current Milestone”) with respect to a Product shall be conclusive evidence of the achievements of all preceding milestone events (excluding [*]) for such Product,
and, to the extent any milestone payment corresponding to any such preceding milestone event has not been made for such Product, such milestone payment shall become due concurrently with the milestone payment triggered by such Current Milestone. In
the event a clinical trial for a particular Product for an Indication is designed as a Phase II/III Clinical Trial, then the milestone payments associated with the Commencement of the Phase III Clinical Trial shall be triggered upon the transition
of the Development activities into the pivotal phase. 
 (f) The identity of the “[*]” and the “[*]”
shall be separately determined for each milestone event based solely upon the order in which such particular milestone event is achieved with respect to the [*]. For example, in the case where the [*] for a particular Product is for [*], the [*] is
for [*], the [*] is for [*], and the [*] is for [*], then [*] shall be deemed the “[*]” for the milestone triggered by the [*]l and [*] shall be deemed the “[*]” for milestone triggered by the [*], and [*] shall be deemed the
“[*]” for the milestone triggered by the [*] and “[*]” for the milestone triggered by the [*]. 
 (g)
Notwithstanding the foregoing, the amounts payable with respect to milestones shall be determined in accordance with all of the following: (i) in the event the first occurrence of any milestone events set forth in Section 8.2(a) and
(b) above is [*], then Biogen Idec shall pay the milestone payment triggered by such milestone event as set forth in the tables above (the “Milestone Amount”) subject to Section 8.2(g)(ii) and (iii); (ii) in the event
the first 

  
 37 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
occurrence of any milestone events set forth in Section 8.2(a) and (b) above (other than [*] and the [*]) is [*], then Biogen Idec shall pay the milestone payment triggered by such
milestone event in the amount [*] of such Milestone Amount, provided that, upon the [*] of the [*] in [*], Biogen Idec shall make another payment to Portola in the amount that equals [*] of such Milestone Amount, provided that, in such event, the
[*] such [*] shall be regarded as the [*] as the [*] such milestone payment for the purpose of construing [*] or [*]; (iii) [*] shall be paid only upon the achievement of such [*] and shall be [*] as follows: (A) [*] such Milestone Amount
shall be due when such [*]; (B) [*] such Milestone Amount shall be due when such [*]; and (C) [*] such Milestone Amount shall be due when such [*]; and (iv) in the event Portola exercises the Opt-Out Option for a particular Product,
the Milestone Amounts for any Milestone Payments with respect to such Product [*] shall be [*] that [*]. For purposes of illustration only, if (x) a Product [*] achieves [*], followed by [*] and then [*], the corresponding milestone amounts
owed for [*] would by [*] dollars ($[*]), [*] dollars ($[*]) and [*] dollars ($[*]), respectively; (y) a Product [*] achieves [*], followed by [*] and then [*], the corresponding milestone amounts owed would by [*] dollars ($[*]), [*] dollars
($[*]) and [*] dollars ($[*]), respectively. 
 8.3 Profit Sharing of Co-Developed Product in the Profit Share
Territory. The terms and conditions of this Section 8.3 shall govern each Party’s rights and obligations with respect to Collaboration Operating Profit (or Losses) for each Product for which Portola has not exercised its Opt-Out Option
under Section 4.5(b). For clarity, if Portola exercises its Opt-Out Option for a particular Product, Portola shall have no right to share Collaboration Operating Profits, and no obligation to bear any Collaboration Operating Losses, with
respect to such Product incurred after the effectiveness of its exercise of the Opt-Out Option. 
 (a) Share of
Collaboration Operating Profits and Collaboration Operating Losses. Subject to Section 8.3(b), the Parties shall share all Collaboration Operating Profits and all Collaboration Operating Losses (as applicable) for each Product in the Profit
Share Territory on the basis of seventy-five percent (75%) to Biogen Idec and twenty-five percent (25%) to Portola. Such sharing of Collaboration Operating Profits (or Losses) for a particular Product shall cease upon exercise of the
Opt-Out Option for such Product. 
 (b) Initial Ex-US Commercialization Loss. 

(i) “Profitable Calendar Quarter” means [*] Calendar Quarters which occur after the First Commercial Sale
of Product has occurred in [*] and during which the Collaboration Operation Profit (excluding Sublicense Revenue) for such Product is positive in the Territory [*]; provided, however, that in all events the first Calendar
Quarter commencing after [*] of the first launch of such Product [*] shall be deemed a Profitable Calendar Quarter with respect to such Product. 
 (ii) For each Product for which Portola has not exercised its Opt-Out Option and prior to the first Profitable Calendar Quarter for such Product: (A) [*] shall [*] the Ex-US Commercialization
Profit (or Loss) for each Calendar Quarter during which the Ex-US Commercialization Profit (or Loss) is negative; and (B) for each Calendar Quarter during which the Ex-US Commercialization Profit (or Loss) is positive, subsection (iii)
shall apply. 

  
 38 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 (iii) For any Calendar Quarter: (A) prior to the first Profitable Calendar
Quarter during which the Ex-US Commercialization Profit (or Loss) is positive; or (B) that is the first Profitable Calendar Quarter or any subsequent Calendar Quarter, [*] shall [*] to [*] of the aggregate Ex-US Commercialization Loss [*] under
subsection (ii) in prior Calendar Quarters [*] profit share obligations [*] under Section 8.3(a) as follows: (x) the [*] of such [*] may be [*] basis [*]; and (y) the [*] may be [*] additional [*] until [*]. 

For purposes of illustration only, if the aggregate Collaboration Operating Loss is $[*] (of which $[*] may be [*]) prior to the first
Calendar Quarter in which there is a Collaboration Operating Profit, and the Collaboration Operating Profits (or Losses) for such [*] and the [*] are $[*] in [*], $[*] in Collaboration Operating Loss and $[*] in Collaboration Operating Profit,
respectively, then: (i) for the [*], [*] will [*] to [*] the profit share [*], so that [*] the Collaboration Operating Profit and [*] the Collaboration Operating Profit, and the [*] Collaboration Operating Loss [*] will be [*]; (ii) for
the [*],[*] will [*], so that [*] under the profit share arrangement, and the [*] will be [*]; and (iii) for the [*], [*] will [*] of the [*] to the [*], so that [*] the Collaboration Operating Profit and [*] the Collaboration Operating Profit,
and the [*] will be [*]. Under a different example, if the aggregate Collaboration Operating Loss is $[*] (of which $[*] may be [*]), and over a series of quarters [*], then in[*] may [*] but may not [*]. 

8.4 Royalty Payments 
 (a) Royalty Rates. 
 (i) Royalty Rates Upon Exercise of the Opt-Out
Option. Upon exercise by Portola of its Opt-Out Option for a particular Product, Biogen Idec shall make royalty payments to Portola on such Product, on a Product by Product basis, based on annual Net Sales of such Product in the Royalty
Territory by Biogen Idec, its Affiliates and sublicensees (excluding distributors) at the applicable rates set forth below: 
  

			
	 Total Net Sales of Applicable Product Throughout the

Territory in any Calendar Year by Biogen Idec, its

Affiliates and/or Sublicensees
	  	Royalty Rate
	 Portion of Net Sales of the applicable Product which are less than or equal to $[*]
	  	[*] percent ([*]%)
	 Portion of Net Sales of the applicable Product which are more than $[*] but less than or equal to $[*]
	  	[*] percent ([*]%)
	 Portion of Net Sales of the applicable Product which are more than $[*] but less than or equal to $[*]
	  	[*] percent ([*]%)
	 Portion of Net Sales of the applicable Product which are more than $[*] but less than or equal to $[*]
	  	[*] percent ([*]%)
	 Portion of Net Sales of the applicable Product which are more than $[*]
	  	[*] percent ([*]%)

  
 39 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 For purposes of illustration only, if Portola has exercised its Opt-Out Option for a
particular Product and Biogen Idec in a Calendar Year during the Royalty Term has [*] dollars of Net Sales of such Product, the royalties payable on Net Sales prior to any applicable reductions based upon Sections 8.4 and 8.5 would be [*]
dollars ($[*]) (i.e., [*] million). 
 (b) Royalties will be payable on a Product-by-Product and country-by-country
basis from First Commercial Sale of such Product on Net Sales of such Product in such country, until the later of: (i) the expiration of the last to expire Valid Claim claiming the composition of matter or formulation of, or the method of
making or using, such Product in such country; (ii) the expiration of the last to expire Government Exclusivity for the Product in such country; or (iii) [*] from the First Commercial Sale of such Product in such country, provided
that, after such period of time but for as long as Portola has an obligation to pay any royalties to any Third Party (including Astellas) under Section 8.5 for the sale of any Product hereunder by Biogen Idec, its Affiliates or sublicensees,
Biogen Idec shall continue to pay Portola royalties in the amount equal to the amount Portola is required to pay such Third Party as a result of such sale. In each case, the period of time during which Biogen Idec is required to pay Portola a
royalty on the sales of such Product in such country is referred to as the “Royalty Term” for such Product in such country. 
 (c) For any Calendar Quarter during the Royalty Term in which: (i) there is a sale of a Generic Product in a particular country; (ii) the sale of a Product in such country is not covered
by a Valid Claim in such country; and (iii) the Product is not protected by Government Exclusivity in such country, the royalty rates set forth in this Section 8.4 applicable to Net Sales of such Product in such country shall be reduced by
[*] for that Calendar Quarter. 
 (d) All royalties are subject to the following conditions: (i) that only
one royalty shall be due with respect to the same unit of Product; (ii) that no royalties shall be due upon the sale or other transfer among Biogen Idec or its Related Parties, but in such cases the royalty shall be due and calculated upon
Biogen Idec’s or its Related Party’s Net Sales to the first independent Third Party; (iii) no royalties shall accrue on the sale or other disposition of Product for use in a Clinical Trial conducted by Biogen Idec or its Related
Parties; and (iv) no royalties shall accrue on the disposition of Product in reasonable quantities by Biogen Idec or its Related Parties as samples (promotion or otherwise) or as donations or for compassionate use (for example, to non-profit
institutions or government agencies for a non-commercial purpose). 
 8.5 Third Party Obligations. 

(a) Portola shall remain responsible for the payment of royalty, milestone and other payment obligations under: (i) the [*];
(ii) the [*]; and (iii) any [*] and [*] that [*] or any [*], so long as [*], provided that, in the event Portola does not exercise its Opt-Out Option for a particular Product, then [*] under [*] with respect to the commercialization
of such Product shall be shared by the Parties as part of the Cost of Sales. Except upon Biogen Idec’s reasonable approval, Portola shall not amend or otherwise modify the MTAs so as to adversely affect Biogen Idec’s rights and obligations
hereunder. 

  
 40 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 (b) In the event that Biogen Idec reasonably determines that rights to intellectual
property owned or Controlled by a Third Party are required in order to research, Develop, manufacture, use, import, sell or otherwise commercialize any Product, Biogen Idec shall have the right to negotiate and acquire such rights through a license
or otherwise. In the event Portola exercises its Opt-Out Option for such Product, then, subject to Section 8.5(a), Biogen Idec shall have the right to deduct from the royalty payments due to Portola under this Agreement for such Product
[*] of the royalties and such other amounts paid by Biogen Idec to such Third Party in respect of such acquired rights applicable to such Product; provided, however, that Biogen Idec shall not have the right to
make such deduction to the extent Biogen Idec obtains such Third Party license for the right to make, use or sell an Active Ingredient, other than a Collaboration Compound, that is included in any Combination Product, and provided,
further, that such reduction shall not reduce the royalty rates otherwise applicable to the Net Sales of such Product by more than [*] in any one Calendar Quarter, but any unused royalty reduction may be credited against
royalties up to [*] in subsequent Calendar Quarters. In the event Portola does not exercise its Opt-Out Option for such Product, then all payments under such Third Party agreement attributed to development, manufacture and/or sale of such
Product shall be treated as costs shared between the Parties as part of the Cost of Sales. 
 8.6 Limit on Royalty
Reduction. Notwithstanding anything to the contrary in this Agreement, in no event will the royalties payable to Portola be reduced to less than a rate equal to [*] of the applicable royalty rate set forth in Section 8.4(a) by the
operation of Sections 8.4(c) and 8.5(b) combined. 
 8.7 Tax. 

(a) Taxes on Income. Each Party shall be solely responsible for the payment of all taxes imposed on its share of income arising
directly or indirectly from the activities of the Parties under this Agreement. 
 (b) Withholding Tax. The Parties agree
to cooperate with one another and use reasonable efforts to lawfully avoid or reduce tax withholding or similar obligations in respect of royalties, milestone payments, and other payments made by the paying Party to the receiving Party under this
Agreement. To the extent the paying Party is required to deduct and withhold taxes on any payment, the paying Party shall pay the amounts of such taxes to the proper Governmental Authority for the account of the receiving Party and remit the net
amount to the receiving Party in a timely manner. The paying Party shall promptly furnish the receiving Party with proof of payment of such taxes. In the event that documentation is necessary in order to secure an exemption from, or a reduction in,
any withholding taxes, the Parties shall provide such documentation to the extent they are entitled to do so. Notwithstanding anything to the contrary in this Agreement, neither Party shall (i) exercise its payment obligations through, or
(ii) assign or otherwise transfer this Agreement or the obligation to make payments hereunder to, in each case, any person located in a country that imposes withholding taxes on royalty payments made to a US beneficial owner, without the
permission of the other Party, which permission shall not be unreasonably withheld. 
 (c) Tax Cooperation. Portola shall
provide Biogen Idec any tax forms that may be reasonably necessary in order for Biogen Idec to not withhold tax or to withhold tax at a 

  
 41 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
reduced rate under an applicable bilateral income tax treaty. Portola shall use reasonable efforts to provide any such tax forms to Biogen Idec in advance of the due date. Each Party shall
provide the other with reasonable assistance to enable the recovery, as permitted by applicable law, of withholding taxes or similar obligations resulting from payments made under this Agreement, such recovery to be for the benefit of the Party
bearing such withholding tax under this Section 8.7. 
 ARTICLE 9 

INTELLECTUAL PROPERTY RIGHTS 
 9.1 Ownership of Inventions. All Inventions which are: (i) discovered or invented solely by employees of a Party or its respective Affiliate or a Third Party acting on behalf of such Party or
its respective Affiliate shall be owned solely by such Party or its respective Affiliate; or (ii) discovered or invented jointly by both (x) Portola or its Affiliates or by a Third Party acting on its behalf and (y) Biogen Idec or its
Affiliates or by a Third Party acting on its behalf shall be owned jointly by Portola and Biogen Idec, with each Party owning an undivided half interest, without a duty of accounting or an obligation to seek consent from the other Party for the
exploitation or sublicensing thereof (subject to any exclusive license granted hereunder) (each a “Joint Invention”); provided that [*], then such Party shall [*]. 

9.2 Patent Prosecution. 
 (a) Within thirty (30) days after the Effective Date, the Parties shall each appoint a representative to handle patent affairs (“Patent Affairs Representative”). Biogen Idec
shall [*] and [*] relating to the Portola Patents and Joint Patents. Through their respective Patent Affairs Representatives, Portola shall consult, [*], with Biogen Idec as to the preparation, filing, prosecution and maintenance of the Portola
Patents and Joint Patents (including, without limitation, any reissues, reexaminations, appeals to appropriate patent offices and/or courts, interferences, derivation proceeding, post-grant review proceedings and foreign oppositions) reasonably
prior to any deadline or action with the U.S. Patent & Trademark Office or any foreign patent office, and shall furnish to Biogen Idec copies of all relevant documents reasonably in advance of such consultation, consider in good faith
Biogen Idec’s comments and suggestions with regard to such preparation, filing, prosecution and/or maintenance (including without limitation any inter partes proceedings) of the patent applications and/or patents within the Portola Patents and
Joint Patents, [*]; provided, however, that in the event of a disagreement between the Patent Affairs Representatives of Portola and Biogen Idec on any such patent prosecution or maintenance matters, such dispute shall be
resolved as set forth in Section 9.2(c). Biogen Idec shall have the right, but not the obligation, to [*] relating to the Portola Patents and Joint Patents. Provided that Biogen Idec is not in material breach of its obligations under this
Agreement, Portola shall not abandon any patent or patent application within the Portola Patents and Joint Patents without Biogen Idec’s prior written consent. Portola shall keep, and shall instruct outside patent counsel to keep, Biogen Idec
regularly informed with regard to the patent preparation, filing, prosecution and maintenance processes. Portola shall promptly deliver, and shall instruct outside patent counsel promptly to deliver, to Biogen Idec copies of all patent applications,
amendments, issued patents, related correspondence, and other related documents. 

  
 42 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 (b) If Portola has not exercised the Opt-Out Option, the Parties shall share all
reasonable Patent Expenses incurred in the prosecution and maintenance of the Portola Patents and Joint Patents in the Profit Share Territory on the basis of [*] to Biogen Idec and [*] to Portola. If Portola has exercised the Opt-Out
Option, [*] shall [*] costs incurred in the prosecution and maintenance of the Portola Patents and Joint Patents. In all events, Biogen Idec shall have the right, exercisable on a patent-by-patent (or patent application-by-patent application) basis
upon [*] written notice to Portola that it no longer wishes to support the prosecution and maintenance of a patent or patent application amongst Portola Patents and Joint Patents, whereupon (i) Portola shall have the right, but not the
obligation, to continue prosecution and maintenance of such patent or patent application at its own expense, and (ii) such patent or patent application shall, [*]. 
 (c) In the event the Patent Affairs Representatives cannot reach agreement as to the strategy or implementation of prosecuting or maintaining Portola Patents or Joint Patents, [*] Patent
Affairs Representative shall have the final decision authority on matters pertaining to [*] and [*] Patent Affairs Representative shall have the final decision authority on all other matters, provided that: (i) in the event [*]
representative makes a decision not to file applications for, or to cease prosecution and/or maintenance of, any [*] in any country or jurisdiction in the Territory, [*] shall have the right (but not the obligation), at its sole discretion and
expense, to file or to continue prosecution or maintenance of such [*] in such country; and (ii) if and when [*] of [*] and decides [*] or [*] this Agreement so that [*] would be [*], [*] Patent Affairs Representative shall no longer have the
final decision making authority with respect to [*] under this Section 9.2(c) and [*] Patent Affairs Representative shall instead have such final decision making authority. Each Party’s Patent Affairs Representative, when exercising such
final decision authority, shall exercise his/her reasonable judgment to obtain and maintain patent coverage of Collaboration Compounds consistent with the application of Commercially Reasonable Efforts for purposes of Development and
commercialization of Products under this Agreement. 
 9.3 Patent Enforcement. 

(a) Each Party will notify the other within [*] of any infringement by a Third Party of any of the Portola Patents or Joint Patents
in the Territory of which such Party becomes aware, including any “patent certification” filed in the United States under 21 U.S.C. §355(b)(2) or 21 U.S.C. §355(j)(2) or similar provisions in other jurisdictions and of any
declaratory judgment, opposition, or similar action alleging the invalidity, unenforceability or non-infringement of any of the Portola Patents or Joint Patents (collectively, an “Infringement”). Any such Infringement that
(x) arises with respect to a [*], or (y) arises from [*] or [*] in the Licensed Field (or any other [*] within the scope of the [*]) shall be deemed a “Product Infringement”. 

(b) Biogen Idec shall have the right to bring and control any legal action in connection with such Product Infringement in the
Territory as it reasonably determines appropriate (provided that Biogen Idec shall not have the right to enforce any [*] with respect to infringing conduct that is outside the scope of the [*]), which right shall be [*] with respect to Product
Infringements concerning [*], and Portola shall have the right to be represented in any such action by counsel of its choice and at its own expense. Biogen Idec shall bear all other 

  
 43 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
reasonable costs incurred in connection with such legal action, provided that, in the event Portola does not exercise its Opt-Out Option, then such expenses incurred with respect to any Patents
Rights in the Profit Share Territory shall be shared on the basis of [*] to Biogen Idec and [*] to Portola as [*]. 
 (c) The enforcing Party shall keep the other Party reasonably informed of the status and progress of such enforcement efforts, shall reasonably consider the other Party’s comments on any such
efforts. At the request of the enforcing Party, the other Party shall provide reasonable assistance in connection therewith, including by executing reasonably appropriate documents, cooperating in discovery and joining as a party to the action if
required. 
 (d) In connection with any such proceeding, the Party bringing the action shall not enter into any
settlement admitting the invalidity of, or otherwise impairing the other Party’s rights in, the Portola Patents or Joint Patents without the prior written consent of the other Party. 

(e) Any recoveries resulting from such an action relating to a claim of Product Infringement shall be first applied against
payment of each Party’s costs and expenses in connection therewith, provided that to the extent that such costs and expenses were shared by the Parties [*] pursuant to Section 9.3(a), then such reimbursement shall be similarly shared. Any
such recoveries in excess of such costs and expenses (the “Remainder”) will be shared by the Parties as follows: (a) if Portola has not exercised the Opt-Out Option, such Remainder shall be treated as Collaboration Operating
Profit and shared by the Parties in accordance with Section 8.3; and (b) if Portola has exercised the Opt-Out Option, then such Remainder shall be [*], provided that [*]. 

(f) Portola shall have the exclusive right to enforce the Portola Patents [*] for any Infringement that is not a Product
Infringement, without obligations to Biogen Idec except (i) as provided in Section 9.2 with respect to Infringements constituting reissues, reexaminations, appeals to appropriate patent offices and/or courts, interferences, derivation
proceeding, post-grant review proceedings and foreign oppositions or similar proceedings, and (ii) Portola shall not enter into any settlement admitting the invalidity of, or otherwise impairing Biogen Idec’s rights in, the Portola Patents
or Joint Patents without the prior written consent of Biogen Idec. Portola shall [*] or [*] with respect to any infringement, expressly including any infringement [*], [*]. 
 9.4 Patent Licensed From Third Parties. Biogen Idec’s rights under this Article 9 with respect to the prosecution, maintenance and enforcement of any Portola Patents that are licensed by
Portola from a Third Party shall be subject to the rights of such Third Party to prosecute, maintain and enforce such Patents. 

9.5 Trademarks. Biogen Idec shall have the right to brand the Products using Biogen Idec related trademarks and any other
trademarks and trade names it determines appropriate for the Products, which may vary by country or within a country (“Product Marks”). Biogen Idec shall own all rights in the Product Marks and register and maintain the Product
Marks in the countries and regions it determines reasonably necessary. 

  
 44 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 9.6 Patent Extensions. 

(a) The Parties shall cooperate in obtaining patent term restoration (under but not limited to Drug Price Competition and Patent
Term Restoration Act), supplemental protection certificates or their equivalents, and patent term extensions with respect to the Portola Patents and/or Joint Patents in any country and/or region where applicable; provided,
however, that [*] shall be extended in connection with [*], [*]. 
 (b) [*] shall determine which Portola
Patent it will apply to extend, and [*] shall file for such extension. At [*] reasonable request, [*] shall provide all reasonable assistance to Biogen Idec in connection with such filing. 

ARTICLE 10 

CONFIDENTIALITY; PUBLICATION 
 10.1 Duty of Confidence. Subject to the other provisions of this Article 10: 
 (a) all Confidential Information disclosed by a Party or its Affiliates under this Agreement will be maintained in confidence and otherwise safeguarded by the recipient Party and its Affiliates, in
the same manner and with the same protection as such recipient Party maintains its own confidential information; 
 (b)
the recipient Party may only use any such Confidential Information for the purposes of performing its obligations or exercising its rights under this Agreement; and 
 (c) the recipient Party may disclose Confidential Information of the other Party only to: (i) its Affiliates, potential sublicensees, sublicensees, potential acquiring parties, and acquiring
parties; and (ii) employees, directors, agents, contractors, consultants and advisers of the recipient Party and its Affiliates and sublicensees, in each case to the extent reasonably necessary for the purposes of, and for those matters
undertaken pursuant to, this Agreement; provided that such Persons are bound to maintain the confidentiality of the Confidential Information in a manner consistent with the confidentiality provisions of this Agreement. 

10.2 Exceptions. The foregoing obligations as to particular Confidential Information of a disclosing Party shall not apply to the
extent that the receiving Party can demonstrate that such Confidential Information: 
 (a) is known by the receiving
Party at the time of its receipt, and not through a prior disclosure by the disclosing Party, as documented by the Receiving Party’s business records or otherwise established by competent evidence; 

(b) is in the public domain by use and/or publication before its receipt from the disclosing Party, or thereafter enters the
public domain through no fault of the Receiving Party; 

  
 45 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 (c) is subsequently disclosed to the receiving Party by a Third Party who may
lawfully do so and is not under an obligation of confidentiality with respect to such Confidential Information to the disclosing Party; or 
 (d) is developed by the receiving Party independently and without use of or reference to any Confidential Information received from the disclosing Party, as documented by the receiving Party’s
business records or otherwise established by competent evidence. 
 Any combination of features or disclosures shall not be
deemed to fall within the foregoing exclusions merely because individual features are published or available to the general public or in the rightful possession of the receiving Party unless the combination itself and principle of operation are
obvious therefrom or are published or available to the general public or in the rightful possession of the receiving Party. 

10.3 Authorized Disclosures. Notwithstanding the obligations set forth in Sections 10.1 and 10.5, a Party may disclose the
other Party’s Confidential Information and the terms of this Agreement to the extent: 
 (a) such disclosure:
(i) is reasonably necessary for the filing or prosecuting Patent Rights as contemplated by this Agreement; (ii) is reasonably necessary in connection with Regulatory Filings for Products as contemplated by this Agreement; (iii) is
reasonably necessary for the prosecuting or defending litigation as contemplated by this Agreement; or (iv) is made to any Third Party bound by written obligation of confidentiality and non-use similar to those set forth under this Article 10,
to the extent otherwise necessary or appropriate in connection with the exercise of its rights or the performance of its obligations hereunder; 
 (b) such disclosure is reasonably necessary: (i) to such Party’s directors, attorneys, independent accountants or financial advisors for the sole purpose of enabling such directors,
attorneys, independent accountants or financial advisors to provide advice to the receiving Party, provided that in each such case on the condition that such directors, attorneys, independent accountants and financial advisors are bound by
confidentiality and non-use obligations substantially consistent with those contained in this Agreement; provided, however, that the term of confidentiality for such directors, attorneys, independent accountants and
financial advisors shall be no less than [*]; or (ii) to actual or potential investors and/or acquirors solely for the purpose of evaluating an actual or potential investment or acquisition; provided that in each such case on the condition that
such actual or potential investors and/or acquirers are bound by confidentiality and non-use obligations substantially consistent with those contained in the Agreement; provided, however, that the term of confidentiality
for such directors, attorneys, independent accountants and financial advisors shall be no less than [*]; 
 (c) such
disclosure is required by judicial or administrative process, provided that in such event such Party shall promptly inform the other Party such required disclosure and provide the other Party an opportunity to challenge or limit the disclosure
obligations. Confidential Information that is disclosed by judicial or administrative process shall remain otherwise subject to the confidentiality and non-use provisions of this Article 10, and the Party disclosing Confidential Information pursuant
to law or court order shall take all steps reasonably 

  
 46 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
necessary, including seeking of confidential treatment or a protective order to ensure the continued confidential treatment of such Confidential Information; and 

(d) such disclosure is deemed necessary by a Party to be disclosed to Related Parties, agent(s), consultant(s) and/or other Third
Parties deemed by such Party and/or its Affiliates to be necessary or advisable in the ordinary course of business in furtherance of the Development, Manufacture and/or commercialization of Collaboration Compounds and/or Products in accordance with
this Agreement on the condition that such Third Parties agree to be bound by confidentiality and non-use obligations that are substantially consistent with those confidentiality and non-use provisions contained in this Agreement;
provided, however, that the term of confidentiality for such Third Parties shall be no less than [*]. 
 10.4 Publication. Publication strategy shall be managed by the JSC, which shall have the right to review and approve any publication, considering Biogen Idec’s and Portola’s interest in
publishing the results of its research in order to obtain recognition within the scientific community and to advance the state of scientific knowledge, the need to protect Confidential Information and the Parties’ mutual interest in obtaining
valid patent protection, protecting reasonable business interests and trade secret information and, having an integrated approach to developing one or more Products for one or more Indications. Consequently, except for disclosures permitted pursuant
to Sections 10.2 and 10.3, either Party or its Affiliates, or its or their employee(s) or consultant(s) shall deliver to the JSC for review and comment a copy of any proposed publication or presentation that pertains to the Collaboration
Compound(s) and/or Product(s), pursuant to a procedure to be established by the JSC. The JSC shall have the right to require modifications of the publication or presentation to protect the Parties’ Confidential Information including trade
secrets and business information; and/or delay such submission for an additional [*] as may be or such longer period as may be reasonably necessary to seek patent protection for the information disclosed in such proposed submission. 

10.5 Publicity/Use of Names. Subject to the rest of this Section 10.5, no disclosure of the existence, or the terms, of this
Agreement may be made by either Party or its Affiliates, and no Party shall use the name, trademark, trade name or logo of the other Party, its Affiliates or their respective employee(s) in any publicity, promotion, news release or disclosure
relating to this Agreement or its subject matter (including the Development of any Product or any Regulatory Filing or Regulatory Approval), without the prior express written permission of the other Party, except as may be required be law.

 (a) A Party may disclose this Agreement and its terms, and material developments or material information generated
under this Agreement, in securities filings with the Securities Exchange Commission (“SEC”) (or equivalent foreign agency) to the extent required by law after complying with the procedure set forth in this Section 10.5. In such
event, the Party seeking such disclosure will prepare a draft confidential treatment request and proposed redacted version of this Agreement to request confidential treatment for this Agreement, and the other Party agrees to promptly (and in any
event, no less than [*] after receipt of such confidential treatment request and proposed redactions) give its input in a reasonable manner in order to allow the Party seeking disclosure to file its request within the time lines proscribed by
applicable SEC regulations. The Party seeking such disclosure shall exercise Commercially 

  
 47 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
Reasonable Efforts to obtain confidential treatment of the Agreement from the SEC as represented by the redacted version reviewed by the other Party. 

(b) Further, each Party acknowledges that the other Party may be legally required to make public disclosures (including in filings
with the SEC or other agency) of certain material developments or material information generated under this Agreement and agrees that each Party may make such disclosures as required by law, provided that the Party seeking such disclosure first
provides the other Party a copy of the proposed disclosure, and provided further that (except to the extent that the Party seeking disclosure is required to disclose such information to comply with applicable laws or regulations) if the other Party
demonstrates to the reasonable satisfaction of the Party seeking disclosure, within [*] of such Party’s providing the copy, that the public disclosure of previously undisclosed information will materially adversely affect the development and/or
commercialization of a Product being developed and/or commercialized, the Party seeking disclosure will remove from the disclosure such specific previously undisclosed information as the other Party shall reasonably request to be removed.

 (c) Notwithstanding the foregoing, Biogen Idec and Portola have agreed on language of a press release announcing the
collaboration, attached hereto as Exhibit K and which may be further modified by the Parties’ mutual written agreement after the Execution Date, to be issued promptly after the execution of the Agreement by both Parties. 

(d) Thereafter, if Portola desires to issue a press release or make a public announcement concerning the material terms of this
Agreement or the Development or commercialization of the Product under this Agreement, such as announcing the Commencement of Phase II Clinical Trials and Phase III Clinical Trials for the Product, the publication of data and results in accordance
with Section 10.4, the Filing of NDAs for the Product and the achievement of Regulatory Approvals of the Product, Portola shall provide Biogen Idec with the proposed text of such announcement for Biogen Idec prior review and approval, such
approval not to be unreasonably withheld or delayed. Biogen Idec shall have the right to make such announcements or issue such press release by providing Portola with reasonable advance notice of the content thereof. 

(e) The Parties agree that after a disclosure pursuant to subsection (b) or a press release pursuant to subsection (c)
or (d) hereof has been reviewed and approved by the other Party, the disclosing Party may make subsequent public disclosures or issue a press release disclosing the same content without having to obtain the other Party’s prior consent and
approval. 
 ARTICLE 11 
 TERM AND TERMINATION 
 11.1 Term. Unless earlier terminated as
permitted by this Agreement, the term of this Agreement will commence upon the Effective Date and continue in full force and effect until the last to occur of the following events, as the case may be: (a) the permanent discontinuation by the
Parties of the Development and commercialization of all Products in the Territory for which Portola has not exercised the Opt-Out Option, and (b) the expiration of the last royalty 

  
 48 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
obligations of Biogen Idec with respect to all Product for which Portola exercised the Opt-Out Option (the “Term”). If Portola exercises the Opt-Out Option with respect to a
particular Product, then upon expiration of the Term, [*]. 
 11.2 Termination by Portola. 

(a) Termination for Cause. Subject to Section 11.4 below, Portola may terminate this Agreement for cause, at any time during
the Term, by giving written notice to Biogen Idec in the event that Biogen Idec commits a material breach of its obligations under this Agreement and such material breach remains uncured for [*] (or [*] for nonpayment of an amount due hereunder),
measured from the date written notice of such material breach is given to Biogen Idec; provided, however, that if any breach is not for non-payment of an amount owed hereunder and is otherwise curable but cannot
reasonably be cured within [*], then Biogen Idec shall submit to Portola a reasonable plan to cure such breach, such termination shall be delayed so long as Biogen Idec continues to make such efforts to cure such breach in accordance with such plan.
Portola shall have the right to terminate this Agreement upon written notice to Biogen Idec in the event Biogen Idec does not continue to cure such breach substantially in accordance with such plan. If the alleged material breach relates to
non-payment of any amount due under this Agreement, the cure period shall be tolled pending resolution of any bona fide dispute between the Parties as to whether such payment is due. 

(b) Termination for Patent Challenge. Portola may terminate this Agreement if Biogen Idec or its Affiliates or sublicensees,
individually or in association with any other person or entity, thereafter commences a legal action challenging the validity, enforceability or scope of any Portola Patents which claim as a composition of matter a Collaboration Compound incorporated
in a Product under Development, provided, however, (i) if this clause is not enforceable under the laws of particular jurisdiction(s), then upon such a termination by Portola which is otherwise proper, this Agreement
shall remain in effect solely in such jurisdiction(s); (ii) this provision shall [*] with respect to any actions of [*] which [*] as [*] and such actions [*], provided that if such [*], such [*] any [*] under this Agreement (including in
connection with [*]); and (iii) this provision shall [*] with respect to any actions of [*] in connection with [*] pertaining to [*] or [*] or [*] under this Agreement. 
 (c) Termination for Bankruptcy. This Agreement may be terminated at any time during the Term by Portola upon Biogen Idec’s filing or institution of bankruptcy, reorganization, liquidation or
receivership proceedings, or upon an assignment of a substantial portion of the assets for the benefit of creditors by the other Party; provided, however, that in the case of any involuntary bankruptcy proceeding such
right to terminate shall only become effective if Biogen Idec consents to the involuntary bankruptcy or such proceeding is not dismissed within [*] after the filing thereof. 
 11.3 Termination by Biogen Idec. 
 (a) Termination for Convenience.
Upon at least one hundred twenty (120) days written notice to Portola, Biogen Idec may terminate this Agreement in its entirety without cause, for any or no reason; provided, however, such one hundred twenty (120) days
shall be reduced to [*] written notice in the event of an 

  
 49 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
adverse safety event or futility determination by Biogen Idec warranting termination of the applicable clinical trial in the reasonable determination of Biogen Idec. 

(b) Termination for Cause. Subject to Section 11.4 below, Biogen Idec may terminate this Agreement for cause, at any time
during the Term, by giving written notice to Portola in the event that Portola commits a material breach of its obligations under this Agreement and such material breach remains uncured for [*] (or [*] for nonpayment of an amount due
hereunder), measured from the date written notice of such material breach is given to Portola; provided, however, that if any breach is not for non-payment of an amount owed hereunder and is otherwise curable but cannot
be reasonably cured within [*], then Portola shall submit a reasonable plan to cure such breach, such termination shall be delayed so long as Portola continues to make such efforts to cure such breach in accordance with such plan. Biogen Idec shall
have the right to terminate this Agreement upon written notice to Portola in the event Portola does not continue to cure such breach substantially in accordance with such plan. If the alleged material breach relates to non-payment of any amount due
under this Agreement, the cure period shall be tolled pending resolution of any bona fide dispute between the Parties as to whether such payment is due. 
 11.4 Consequence for Inability to Co-Fund or Co-Promote. Notwithstanding Section 11.3(b), (i) in the event Portola fails to co-fund the Development of a Product [*] for such
Product, then, subject to the notice and cure provisions set forth in Section 11.3(b) above, Portola shall [*] such Product and shall [*] for such Product [*] of such Product and [*], provided that [*]; and (ii) in the event Portola fails
to co-fund the Development of a Product [*] for such Product, then, subject to the notice and cure provisions set forth in Section 11.3(b) above, Portola shall [*] for such Product and Biogen Idec shall [*] and [*] but [*] with respect to such
Product [*], but Biogen Idec shall [*]. In such event, Portola shall [*]or [*] such Product, provided that in each case of (i) and (ii), such failure to fund shall not be deemed Portola’s breach of its obligations under this Agreement, and
Biogen Idec shall not have the right to terminate this Agreement or seek damages as a result beyond the payments provided under this Section 11.4. Notwithstanding Section 11.2(a) and 11.3(b), in the event the Party that has exercised its
Co-Promotion Option breaches its Co-Promotion obligations with respect to a Product under this Agreement or the applicable Co-Promotion Agreement, then, subject to the notice and cure provisions set forth in Section 11.2(a) or 11.3(b) above, as
applicable, the other Party shall have the right to [*] and [*] with respect to such Product, but such other Party shall not have the right to [*]. 
 11.5 Effects of Termination. 
 (a) Termination by Biogen Idec for
Convenience, or by Portola for Cause, Patent Challenge or Biogen Idec’s Bankruptcy. Upon termination of this Agreement by Biogen Idec for convenience pursuant to Section 11.3(a), or by Portola for cause, patent challenge or Biogen
Idec’s bankruptcy pursuant to Section 11.2, the following consequences shall apply to the termination and shall be effective as of the effective date of such termination: 

(i) each Party shall pay all amounts then due and owing to the other Party as of the termination date; 

  
 50 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 (ii) the Parties shall cooperate to minimize all expenses incurred between the
notice date and the termination of the Agreement and in all events no new clinical trials shall be commenced during such period unless the Portola bears the full expense for such clinical trials; 

(iii) all licenses and other rights granted to Biogen Idec under the Portola Technology and Joint Technology will terminate;

 (iv) no later than [*] after the effective date of such termination, each Party shall return or cause to be
returned to the other Party (or at its option certify to the other Party the destruction of) all Confidential Information in tangible form received from the other Party and all copies thereof and all Materials, substances or compositions delivered
or provided by the other Party; provided, however, that (A) Portola may retain any such Confidential Information or materials as reasonably necessary for Portola’s continued practice under any license under this
Agreement that does not terminate upon such termination pursuant to this Section 11.5, and (B) each Party may keep one copy of Confidential Information received from the other Party in its confidential files for record purposes;

 (v) Biogen Idec will assign to Portola all Regulatory Filings and Regulatory Approvals specific to the applicable
Products in the Territory, provided that any Biogen Idec Know-How contained in such Regulatory Filings and Regulatory Approvals shall be subject to the license grants set forth in Section 11.5(a)(vii). Biogen Idec shall, at Portola’s
expense use Commercially Reasonable Efforts to cause its Contract Manufacturers to give Portola a right of reference to any DMF for Collaboration Compound and/or Product; 
 (vi) if Biogen Idec is responsible for the Manufacture of the Collaboration Compound or Product, Biogen Idec shall, at Portola’s request and expense, provide reasonable technical assistance
and transfer all Biogen Idec Know-How necessary to Manufacture Collaboration Compound and Product to Portola or its designee or at Biogen Idec’s option, assign its rights under contracts related solely to Products with Contract Manufacturers to
Portola; 
 (vii) Biogen Idec hereby grants Portola an exclusive as to Biogen Idec Patents and non-exclusive as to
Biogen Idec Know-How, perpetual license, with a right of sublicense, under Biogen Idec Technology (subject to Biogen Idec’s obligations to any Third Parties) solely to the extent reasonably necessary for Portola to make, use, sell, offer for
sale or import the terminated Products as are then being Developed, marketed or Manufactured by Biogen Idec, its Affiliates or sublicensees as of the date of such termination. Such license shall be: (A) fully-paid and royalty-free if on the
effective date of such termination [*]; (B) if as of the effective date of such termination [*], but [*], subject to a royalty of [*] from Portola to Biogen Idec on all Net Sales of terminated Product during such period that would have
constituted the Royalty Term had Portola exercised its Opt-Out Option for such Product and the Agreement had not been terminated; and (C) if as of the effective date of such termination [*] but [*], subject to a royalty of [*] from Portola to
Biogen Idec on all Net Sales of terminated Product during such period that would have constituted the Royalty Term had Portola exercised it Opt-Out Option for such Product and the Agreement had not been terminated; and (D) if as of the
effective date of such termination [*], subject to a royalty of [*] from Portola to Biogen Idec 

  
 51 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
on all Net Sales of terminated Product during such period that would have constituted the Royalty Term had Portola exercised its Opt-Out Option for such Product and the Agreement had not been
terminated. If [*] or [*] the grant of such licenses by Biogen Idec to Portola, then such [*] shall be [*]; 
 (viii) if
Biogen Idec is manufacturing Collaboration Compound or Product for commercial sale, Biogen Idec shall, at Portola’s election, supply Portola with Biogen Idec’s existing inventory of Collaboration Compound or Product that is compliant with
applicable laws and specifications (unless such inventory is in Biogen Idec’s trade dress, in which case this subsection shall not apply) at Biogen Idec’s Manufacturing Costs, ordered pursuant to a single written purchase order placed by
Portola within [*] after the notice of such termination; 
 (ix) Biogen Idec shall, at Portola’s request,
expense and election, use Commercially Reasonably Efforts to facilitate negotiations between Portola and Biogen Idec’s Third Party providers of clinical research, Manufacturing and/or distribution services; 

(x) if Biogen Idec, its Affiliates or sublicensees is conducting one or more human clinical trial(s) for the Product at the time
of such termination, then, at Portola’s election on a trial-by-trial basis: (A) Biogen Idec shall fully cooperate with Portola at Portola’s expense to transfer the conduct of such human clinical trial(s) to Portola and Portola shall
assume any and all liability for such human clinical trial(s) as of the effective date of such termination, provided that Biogen Idec shall bear its portion of the costs for clinical trials which were ongoing at the time of its receipt
of the notice of termination for [*] without [*] and thereafter Portola shall bear all costs and expenses incurred in connection with the conduct of such clinical trial(s); or (B) Biogen Idec shall, at its sole expense, orderly wind down the
conduct of any such human clinical trial(s) which is not assumed by Portola; and 
 (xi) except as set forth in this
Section 11.5(a) and Section 11.6 and for the surviving provisions set forth in Section 11.7, the rights and obligations of the Parties hereunder shall terminate. 

(b) Termination by Biogen Idec for Cause. Upon termination of this Agreement by Biogen Idec pursuant to Section 11.3(b), the
following consequences shall apply to the termination and shall be effective as of the effective date of such termination: 

(i) each Party shall pay all amounts then due and owing to the other Party as of the termination date; 

(ii) the Parties shall cooperate to minimize all expenses incurred between the notice date and the termination of the Agreement
and in all events no new clinical trials shall be commenced during such period unless Portola bears the full expense for such clinical trial; 
 (iii) [*] shall [*] as set forth in [*]; provided that Portola shall [*] and Biogen Idec shall [*] in accordance with the terms and conditions [*], which shall survive such
termination of the Agreement; provided that [*] and [*] and [*] would have [*] may be [*]; 

  
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[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 (iv) no later than [*] after the effective date of such termination, each
Party shall return or cause to be returned to the other Party all Confidential Information in tangible form received from the other Party and all copies thereof and all Materials, substances or compositions delivered or provided by the other Party;
provided, however, that (A) Biogen Idec may retain any such Confidential Information or materials as reasonably necessary [*] under this Agreement [*], and (B) each Party may keep one copy of Confidential
Information received from the other Party in its confidential files for record purposes; and 
 (v) except as set forth
in this Section 11.5(b) and Section 11.6 and for the surviving provisions set forth in Section 11.7, the rights and obligations of the Parties hereunder shall terminate. 

11.6 Accrued Rights. Expiration or termination of this Agreement for any reason shall be without prejudice to any right which
shall have accrued to the benefit of either Party prior to such termination, including damages arising from any breach under this Agreement. Expiration or termination of this Agreement shall not relieve either Party from any obligation which is
expressly indicated to survive such expiration or termination. 
 11.7 Survival. The provisions of Sections 9.1, 11.5,
11.6, 11.7, 11.12, and Article 1, Article 10, Article 13 and Article 14 shall survive the expiration or termination of this Agreement. 
 11.8 Provision for Insolvency. Portola shall be deemed a “Debtor” under this Agreement if, at any time during the Term (a) a case is commenced by or against Portola under the
U.S. Bankruptcy Code (the “Code”), (b) Portola files for, or a final order is entered placing Portola in, bankruptcy, reorganization, liquidation or receivership proceedings (other than a case under the Code), (c) Portola
make a general assignment for the benefit of its creditors, or (d) a receiver or custodian is appointed for all or substantially all of Portola’s business; provided, however, that in the case of any involuntary
case under the Code, Portola shall not be deemed a Debtor if the case is dismissed within [*] after the commencement thereof. In the event that Portola is deemed a Debtor, Biogen Idec may terminate this Agreement by providing written notice
to Portola. All licenses granted under this Agreement are deemed to be, for purposes of Section 365(n) of the Code, licenses of rights to “intellectual property” as defined in Section 101 of the Code, and Biogen Idec shall have
such rights as are provided under the Code in the event of the bankruptcy of Portola. 
 11.9 Licenses. If a case is
commenced under the Code by or against Portola, Portola (in any capacity, including debtor-in-possession) and its successors and assigns (including a trustee) shall: 
 (a) as Biogen Idec may elect in a written request, immediately upon such request: 
 (i) unless and until the rejection of this Agreement, perform all of the obligations provided in this Agreement to be performed by Portola, including, where applicable, providing to Biogen Idec
portions of intellectual property licensed hereunder (including 

  
 53 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
embodiments thereof) held by Portola or such successors and assigns or otherwise available to them; or 
 (ii) provide to Biogen Idec all such intellectual property (including all embodiments thereof) held by Portola or such successors and assigns or otherwise available to them; and 

(iii) not interfere with Biogen Idec’s rights under this Agreement, or any agreement supplemental hereto, to such
intellectual property (including such embodiments), including any right to obtain such intellectual property (or such embodiments) from another entity. 
 11.10 Rights to Intellectual Property. If (a) a case under the Code is commenced by or against Portola, (b) this Agreement is rejected as provided in the Code and (c) Biogen Idec
elects to retain its rights hereunder as provided in Section 365(n)(1)(B) of the Code, then Portola (in any capacity, including debtor-in-possession) and its successors and assigns (including any trustee) shall provide to Biogen Idec all
intellectual property licensed hereunder, and agrees to [*] and [*] and to [*] and to [*] and, in the case of [*] or [*] or [*], to [*], or otherwise [*] or [*]: (i) [*] and [*] and [*], (ii) all of the following (to the extent that any of
the following are so related): [*] and [*], (iii) [*] and [*], (iv) [*], (v) [*], (vi) [*], (vii) [*], and (viii) [*] and [*] pursuant to Section 365(n) of the Code, and (ix) [*], whether [*] or [*] but [*]
and to [*]. In addition, upon such election, Portola shall [*] or [*] and [*] hereunder and [*] in accordance with this Agreement and agrees to use Commercially Reasonable Efforts to [*] and [*] to [*] and [*] or [*] as reasonably necessary [*] or
[*] in accordance with this Agreement. Whenever Portola or any of its successors or assigns provides to Biogen Idec any of the intellectual property licensed hereunder (or any embodiment thereof) pursuant to this Section 11.10, Biogen Idec
shall have the right, but not the obligation, to perform the obligations of Portola hereunder with respect to such intellectual property, but [*] shall [*] or the [*]. 
 11.11 Additional Rights. All rights, powers and remedies of Biogen Idec provided herein are in addition to and not in substitution for any and all other rights, powers and remedies now or hereafter
existing at law or in equity (including the Code) in the event of the commencement of a case under the Code. The Parties agree that they intend the following rights to extend to the maximum extent permitted by law, and to be enforceable under Code
Section 365(n): 
 (a) the right of access to any intellectual property (including all embodiments thereof) of
Portola, or any Third Party with whom Portola contracts to perform an obligation of Portola under this Agreement, and, in the case of the Third Party, which is necessary for the Development, Manufacture, Commercialization or use of Products; and

 (b) the right to contract directly with any Third Party to complete the contracted work. 

11.12 Termination Not Sole Remedy. Termination is not the sole remedy under this Agreement and, whether or not termination is
effected and notwithstanding anything contained 

  
 54 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
in this Agreement to the contrary, all other remedies will remain available except as agreed to otherwise herein. 
 ARTICLE 12 
 REPRESENTATIONS AND WARRANTIES 

12.1 Representations and Warranties of Each Party. Each Party represents and warrants to the other Party as of the Execution Date
that: 
 (a) it is a corporation duly organized, validly existing and in good standing under the laws of the jurisdiction
of its organization, and has the full right, power and authority to enter into this Agreement, to perform its obligations hereunder; and 
 (b) this Agreement has been duly executed by it and is legally binding upon it, enforceable in accordance with its terms, and does not conflict with any agreement, instrument or understanding, oral
or written, to which it is a party or by which it may be bound, nor violate any material law or regulation of any court, governmental body or administrative or other agency having jurisdiction over it. 

12.2 Representations and Warranties by Portola. Portola represents and warrants to Biogen Idec as of the Execution Date that:

 (a) it has not previously assigned, transferred, conveyed or otherwise encumbered its right, title and interest in
Portola Patents or Portola Know-How in a manner that is inconsistent with the exclusive license granted to Biogen Idec under Section 2.1(a); 
 (b) it and its Affiliates have not previously granted to any Third Party any rights then Controlled by Portola or its Affiliates in any Syk Selective Inhibitors in the Licensed Field, other than
pursuant to the MTAs; 
 (c) to its knowledge, none of the Portola Patents is invalid or unenforceable; 

(d) it is the sole and exclusive owner or licensee of the Portola Patents and Portola Know-How, all of which are free and clear of
any lien, charges and encumbrances, and no other person, corporate or other private entity, or governmental entity or subdivision thereof, has or shall have any claim of ownership whatsoever with respect to Portola Patents and Portola Know-How owned
by Portola; 
 (e) it has disclosed to Biogen Idec the existence of any patent opinions related to the Portola Patents
and Portola Know-How; 
 (f) to its knowledge, other than [*] and [*], there are no [*] that [*] as a result of the [*]
in the [*] as of the Execution Date and [*] or [*]; 
 (g) to its knowledge, the development and use of Collaboration
Compounds in the manner that is and has been conducted by Portola do not infringe any intellectual property 

  
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[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
rights owned or possessed by any Third Party and do not breach or infringe any obligation of confidentiality or non-use owed by Portola to a Third Party; 

(h) there are no claims, judgments or settlements against or owed by Portola with respect to the Portola Patents or Portola
Know-How, and to the best of Portola’s knowledge, there are no pending or threatened claims or litigation; in each case relating to the Portola Patents or Portola Know-How; and 

(i) [*] has the profile delivered to Biogen Idec by Portola prior to the Execution Date. 

12.3 No Other Warranties. EXCEPT AS EXPRESSLY STATED IN THIS ARTICLE 12 (A) NO REPRESENTATION, CONDITION OR WARRANTY
WHATSOEVER IS MADE OR GIVEN BY OR ON BEHALF OF BIOGEN IDEC OR PORTOLA; AND (B) ALL OTHER CONDITIONS AND WARRANTIES WHETHER ARISING BY OPERATION OF LAW OR OTHERWISE ARE HEREBY EXPRESSLY EXCLUDED, INCLUDING ANY CONDITIONS AND WARRANTIES OF
MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE OR NON-INFRINGEMENT. 
 ARTICLE 13 

INDEMNIFICATION; LIABILITY 
 13.1 Indemnification by Portola. Subject to Section 13.3, Portola shall indemnify, defend and hold harmless Biogen Idec, its Affiliates, their respective directors, officers, employees and
agents, and their respective successors, heirs and assigns (collectively, the “Biogen Idec Indemnitees”), against all liabilities, damages, losses and expenses (including without limitation, reasonable attorneys’ fees and
expenses of litigation) (collectively, “Losses”) incurred by or imposed upon the Biogen Idec Indemnitees, or any of them, as a direct result of claims, suits, actions, demands or judgments of Third Parties, including without
limitation personal injury and product liability claims (collectively, “Claims”), arising out of a [*] or the Manufacture, use or sale by Portola or any of its Affiliates, sublicensees, distributors or agents of any Product or
Retained Field Product, except with respect to any Claim or Losses that result from a breach of this Agreement (or any agreement entered into by and between the Parties pursuant to any provision hereunder) by, or the gross negligence or willful
misconduct of, Biogen Idec, provided that, with respect to any Clam for which Portola has an obligation to any Biogen Idec Indemnitee pursuant to this Section 13.1 and Biogen Idec has an obligation to any Portola Indemnitee pursuant to
Section 13.2, each Party shall indemnify each of the other Party’s Indemnitees for its Losses to the extent of its responsibility, relative to the other Party, for the facts underlying the Claim. 

13.2 Indemnification by Biogen Idec. Subject to Section 13.3, Biogen Idec shall indemnify, defend and hold harmless Portola,
its Affiliates, their respective directors, officers, employees and agents, and their respective successors, heirs and assigns (collectively, the “Portola Indemnitees”), against all Losses incurred by or imposed upon the Portola
Indemnitees, or any of them, as a direct result of Claims arising out of the Manufacture, use or sale by Biogen Idec or any of its Affiliates, sublicensees, distributors or agents of any Product,

  
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[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
except with respect to any Claim or Losses that result from a Niche Indication [*] or a breach of this Agreement (or any agreement entered into by and between the Parties pursuant to any
provision hereunder) by, or the gross negligence or willful misconduct of, Portola, provided that, with respect to any Clam for which Biogen Idec has an obligation to any Portola Indemnitee pursuant to this Section 13.2 and Portola has an
obligation to any Biogen Idec Indemnitee pursuant to Section 13.1, each Party shall indemnify each of the other Party’s Indemnitees for its Losses to the extent of its responsibility, relative to the other Party, for the facts underlying
the Claim. 
 13.3 Product Liability. 
 (a) Unless and until Portola exercises its Opt-Out Option for a particular Product, any Claims arising out of any Third Party claim, suit, action, proceeding, liability or obligation involving any
actual or alleged death or bodily injury arising out of or resulting from the Development, Manufacture or Commercialization of such Product for use or sale in the Licensed Field in the Profit Share Territory, to the extent that such Claims exceed
the amount (if any) covered by the applicable Party’s product liability insurance (“Excess Product Liability Costs”), shall be paid by Biogen Idec and shared by the Parties as Collaboration Operating Losses for such Product,
except to the extent such Claims are based on the negligence or willful misconduct of any Portola Indemnitee or Biogen Idec Indemnitee or are subject to Portola’s indemnification obligations under Section 4.1(c)(iv), in which case the
Parties’ respective rights and obligations with respect to such Excess Product Liability Costs shall be governed under Section 13.1 or 13.2, as applicable. 
 (b) Each party shall maintain appropriate product liability insurance with respect to the Development, Manufacture and Commercialization of any Products for use or sale in the Licensed Field with
reputable and financially secure insurance carriers, with coverage limits of not less than [*] per occurrence subject to such deductibles and policy exclusions as are reasonable and customary. Notwithstanding the foregoing, Biogen Idec may
self-insure to the extent that it self-insures for its other products but only if Biogen Idec’s sales of pharmaceutical products exceeds [*] in the most recently completed Calendar Year for which Biogen Idec elects to be self-insured, provided
that, in the event of such self-insurance, Biogen Idec’s per occurrence coverage limit shall be deemed [*] for the purpose of calculating the Excess Product Liability Costs. 

(c) For clarity, if Portola has not exercised its Opt-Out Option for a particular Product, the risk of product liability for such
Product shall be shared by Biogen Idec and Portola 75:25 through the operation of the Collaboration Operating Profit (or Loss), except (i) to the extent such Claim is covered by product liability insurance of a Party, (ii) [*] or
(iii) in respect of Claims which arise from the negligence or willful misconduct of a Biogen Idec Indemnitee or Portola Indemnitee, in which case the responsible Party shall be solely responsible for the related Losses, whether or not covered
by such Party’s product liability insurance. If Portola has exercised its Opt-Out Option for a particular Product, then the indemnity provisions of Section 13.1 and 13.2 shall apply without modification. 

13.4 Indemnification Procedure. If either Party is seeking indemnification under Sections 13.1 or 13.2 (the
“Indemnified Party”), it shall inform the other Party (the 

  
 57 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
“Indemnifying Party”) of the claim giving rise to the obligation to indemnify pursuant to such section as soon as reasonably practicable after receiving notice of the claim. The
Indemnifying Party shall have the right to assume the defense of any such claim for which it is obligated to indemnify the Indemnified Party. The Indemnified Party shall cooperate with the Indemnifying Party and the Indemnifying Party’s insurer
as the Indemnifying Party may reasonably request, and at the Indemnifying Party’s cost and expense. The Indemnified Party shall have the right to participate, at its own expense and with counsel of its choice, in the defense of any claim or
suit that has been assumed by the Indemnifying Party. Neither Party shall have the obligation to indemnify the other Party in connection with any settlement made without the Indemnified Party’s written consent, which consent shall not be
unreasonably withheld or delayed. If the Parties cannot agree as to the application of Section 13.1 or 13.2 as to any claim, pending resolution of the dispute pursuant to Section 14.7, the Parties may conduct separate defenses of such
claims, with each Party retaining the right to claim indemnification from the other Party in accordance with Section 13.1 or 13.2 upon resolution of the underlying claim. 
 13.5 Mitigation of Loss. Each Indemnified Party will take and will procure that its Affiliates take all such reasonable steps and action as are reasonably necessary or as the Indemnifying Party may
reasonably require in order to mitigate any Claims (or potential losses or damages) under this Article 13. Nothing in this Agreement shall or shall be deemed to relieve any Party of any common law or other duty to mitigate any losses incurred by it.

 13.6 Special, Indirect and Other Losses. EXCEPT IN THE EVENT OF A PARTY’S BREACH OF ITS OBLIGATIONS UNDER
SECTION 2.4 OR ARTICLE 10, NEITHER PARTY NOR ANY OF ITS AFFILIATES SHALL BE LIABLE IN CONTRACT, TORT, NEGLIGENCE, BREACH OF STATUTORY DUTY OR OTHERWISE FOR ANY CONSEQUENTIAL, SPECIAL OR PUNITIVE DAMAGES OR FOR LOSS OF PROFITS SUFFERED BY
THE OTHER PARTY, EXCEPT TO THE EXTENT ANY SUCH DAMAGES ARE REQUIRED TO BE PAID TO A THIRD PARTY AS PART OF A CLAIM FOR WHICH A PARTY PROVIDES INDEMNIFICATION UNDER THIS ARTICLE 13. 

ARTICLE 14 

GENERAL PROVISIONS 
 14.1 Force Majeure. Neither Party shall be held liable to the other Party nor be deemed to have defaulted under or breached this Agreement for failure or delay in performing any obligation under
this Agreement to the extent such failure or delay is caused by or results from causes beyond the reasonable control of the affected Party, potentially including, but not limited to, embargoes, war, acts of war (whether war be declared or not), acts
of terrorism, insurrections, riots, civil commotions, strikes, lockouts or other labor disturbances, fire, floods, or other acts of God, or acts, omissions or delays in acting by any governmental authority or the other Party or unavailability of
Materials related to the Manufacture of Products. The affected Party shall notify the other Party of such force majeure circumstances as soon as reasonably practical, and shall promptly undertake and continue diligently all reasonable efforts
necessary to cure such force majeure circumstances or to perform its obligations in spite of the ongoing circumstances. 

  
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[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 14.2 Assignment. This Agreement may not be assigned or otherwise transferred, nor may
any right or obligation hereunder be assigned or transferred, by either Party without the prior written consent of the other Party. Notwithstanding the foregoing, either Party may, without consent of the other Party, assign this Agreement and its
rights and obligations hereunder in whole or in part to an Affiliate of such Party, or in whole to its successor in interest in connection with the sale of all or substantially all of its stock or its assets to which this Agreement relates, or in
connection with a merger, acquisition or similar transaction. Any attempted assignment not in accordance with this Section 14.2 shall be null and void and of no legal effect. Any permitted assignee shall assume all assigned obligations of its
assignor under this Agreement. The terms and conditions of this Agreement shall be binding upon, and shall inure to the benefit of, the Parties and their respected successors and permitted assigns. For clarity, the intellectual property rights of
the assignee in a Change of Control transaction, as existing on the date of closing of such transaction, shall be automatically excluded from the rights licensed to the other Party under this Agreement, subject however to Section 2.4(b).

 14.3 Change of Control. Except as expressly set forth under Section 4.5(b), the terms and conditions of this
Agreement, including Portola’s commercialization rights under Section 7.2(b), shall [*]. The Party undergoing a Change of Control shall provide written notice to the other Party promptly after the completion of any such Change of
Control. 
 14.4 Severability. If any one or more of the provisions contained in this Agreement is held invalid, illegal
or unenforceable in any respect, the validity, legality and enforceability of the remaining provisions contained herein shall not in any way be affected or impaired thereby, unless the absence of the invalidated provision(s) adversely affects the
substantive rights of the Parties. The Parties shall in such an instance use their best efforts to replace the invalid, illegal or unenforceable provision(s) with valid, legal and enforceable provision(s) which, insofar as practical, implement the
purposes of this Agreement. 
 14.5 Notices. All notices which are required or permitted hereunder shall be in writing
and sufficient if delivered personally, sent by facsimile (and promptly confirmed by personal delivery, registered or certified mail or overnight courier), sent by nationally-recognized overnight courier or sent by registered or certified mail,
postage prepaid, return receipt requested, addressed as follows: 
 If to Portola: 

Portola Pharmaceuticals, Inc. 
 270 East Grand Avenue, Suite 22 
 South San Francisco, CA 94080 

Attn:     Chief Executive Officer 
 Fax:       (650) 246-7376 

  
 59 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 with a copy to: 
 Cooley LLP 
 3175 Hanover Street 

Palo Alto, CA 94304 
 Attn:     Robert L. Jones, Esq. 

Fax:      (650) 849-7400 
 If to Biogen Idec: 
 Biogen Idec MA Inc. 

14 Cambridge Center 
 Cambridge, MA, 02142 
 Attn:     Doug Williams, 

  Executive Vice President Research & Development 

Fax:      866 406 0527 
 with a copy to: 
 Biogen Idec MA Inc. 

14 Cambridge Center 
 Cambridge, MA, 02142 
 Attn:     Susan Alexander, 

  Executive Vice President and General Counsel 
 Fax:      866 546 2758 
 or to such other address(es) as the Party to
whom notice is to be given may have furnished to the other Party in writing in accordance herewith. Any such notice shall be deemed to have been given: (a) when delivered if personally delivered or sent by facsimile on a business day (or if
delivered or sent on a non-business day, then on the next business day); (b) on the business day after dispatch if sent by nationally-recognized overnight courier; or (c) on the fifth (5th) business day following the date of mailing,
if sent by mail. 
 14.6 Governing Law. This Agreement shall be governed by and construed in accordance with the laws of
the State of New York and the patent laws of the United States without reference to any rules of conflict of laws. 
 14.7
Consent to Jurisdiction. Each Party to this Agreement, by its execution hereof: (a) hereby irrevocably submits to the exclusive jurisdiction of the state courts of the State of New York in New York County or the United States District Court
for the Southern District of New York for the purpose of any and all actions, suits or proceedings arising in whole or in part out of, based upon or in connection with this Agreement or the subject matter hereof; (b) hereby waives to the extent
not prohibited by applicable law, and agrees not to assert, by way of motion, as a defense or otherwise, in any such action, any claim that it is not subject personally to the jurisdiction of the above-named courts, that its property is exempt or
immune from attachment or execution, that any such action brought in one of the above-named courts should be dismissed on grounds of forum non conveniens, should be transferred to any court other than one of the above-named courts, or should be
stayed by reason of the pendency of some other proceeding in any 

  
 60 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
other court other than one of the above-named courts, or that this Agreement or the subject matter hereof may not be enforced in or by such court; and (c) hereby agrees not to commence any
such action other than before one of the above-named courts nor to make any motion or take any other action seeking or intending to cause the transfer or removal of any such action to any court other than one of the above-named courts whether on the
grounds of inconvenient forum or otherwise. 
 14.8 Entire Agreement; Amendments. This Agreement, together with the
Schedules and Exhibits hereto, contains the entire understanding of the Parties with respect to the Collaboration and the licenses granted hereunder. Any other express or implied agreements and understandings, negotiations, writings and commitments,
either oral or written, in respect to the Collaboration and the licenses granted hereunder are superseded by the terms of this Agreement. The Schedules and Exhibits to this Agreement are incorporated herein by reference and shall be deemed a part of
this Agreement. This Agreement may be amended, or any term hereof modified, only by a written instrument duly executed by authorized representative(s) of both Parties hereto. The Parties agree that, effective as of the Effective Date, that certain
Confidentiality Agreement between the Parties dated as of [*] (“Confidentiality Agreement”) shall be superseded by this Agreement, and that disclosures made prior to the Effective Date pursuant to the Confidentiality
Agreement shall be subject to the confidentiality and non-use provisions of this Agreement. 
 14.9 Headings. The
captions to the several Articles, Sections and subsections hereof are not a part of this Agreement, but are merely for convenience to assist in locating and reading the several Articles and Sections hereof. 

14.10 Export Control. This Agreement is made subject to any restrictions concerning the export of products or technical
information from the United States of America or other countries which may be imposed upon or related to Portola or Biogen Idec from time to time. Each Party agrees that it will not export, directly or indirectly, any technical information acquired
from the other Party under this Agreement or any products using such technical information to a location or in a manner that at the time of export requires an export license or other governmental approval, without first obtaining the written consent
to do so from the appropriate agency or other governmental entity. 
 14.11 Independent Contractors. It is expressly
agreed that Portola and Biogen Idec shall be independent contractors and that the relationship between the two Parties shall not constitute a partnership, joint venture or agency. Neither Portola nor Biogen Idec shall have the authority to make any
statements, representations or commitments of any kind, or to take any action, which shall be binding on the other Party, without the prior written consent of the other Party. 
 14.12 Waiver. The waiver by either Party hereto of any right hereunder, or of any failure of the other Party to perform, or of any breach by the other Party, shall not be deemed a waiver of any
other right hereunder or of any other breach by or failure of such other Party whether of a similar nature or otherwise. 

  
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[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 14.13 Cumulative Remedies. No remedy referred to in this Agreement is intended to be
exclusive, but each shall be cumulative and in addition to any other remedy referred to in this Agreement or otherwise available under law or equity. 
 14.14 Waiver of Rule of Construction. Each Party has had the opportunity to consult with counsel in connection with the review, drafting and negotiation of this Agreement. Accordingly, the rule of
construction that any ambiguity in this Agreement shall be construed against the drafting Party shall not apply. 
 14.15
Counterparts. This Agreement may be executed in two or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. 

14.16 Antitrust Filings. 
 (a) Each of Biogen Idec and Portola agrees to prepare and make appropriate filings under the Hart-Scott Rodino (HSR) Act and other antitrust requirements relating to this Agreement and the
transactions contemplated hereby as soon as reasonably practicable after the Execution Date (“HSR Filing Date”), and Biogen Idec shall bear the filing fees associated with any HSR filing, but each Party shall otherwise bear its own
costs in connection with such filings. The Parties agree to cooperate in the antitrust clearance process and to furnish promptly to the Federal Trade Commission (FTC), the Antitrust Division of the Department of Justice (DOJ) and any other agency or
authority, any information reasonably requested by them in connection with such filings. With respect to the HSR and other filings made pursuant to this Section 14.16(a), each of Biogen Idec and Portola shall, to the extent practicable:
(i) promptly notify the other Party of any material communication to that Party from the FTC, the DOJ, or any other agency or authority and, subject to applicable law and discuss with and permit the other Party to review in advance any proposed
written communication to any of the foregoing; (ii) not agree to participate in any substantive meeting or discussion with the FTC, the DOJ or any other agency or authority in respect of any filings, investigation or inquiry concerning this
Agreement unless it consults with the other Party in advance and, to the extent permitted by such the FTC, the DOJ or any other agency or authority, give the other Party the opportunity to attend and participate thereat; and (iii) furnish the
other Party with copies of all correspondence and communications (and memoranda setting forth the substance thereof) between them and their Affiliates and their respective representatives on the one hand, and the FTC, the DOJ or any other agency or
authority or members of their respective staffs on the other hand, with respect to this Agreement. Notwithstanding any of the foregoing, nor anything else contained in this Agreement, Biogen Idec shall not be required, in order to avoid, eliminate,
or resolve any objections or impediments under any antitrust, competition, or trade regulation law that may be asserted by the FTC, the DOJ or any other agency or governmental authority relating to this Agreement and the transactions contemplated
hereby, to propose, negotiate, commit to or effect, by consent decree, hold separate order, or otherwise, the license, sale, divestiture or disposition or otherwise take or commit to take any action which it is capable of taking that would restrict
or limit its freedom of action, ownership, or operations, with respect to any assets or businesses of Biogen Idec or its respective Affiliates, or (y) any rights granted to Biogen Idec under this Agreement. 

  
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[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 (b) Other than the provisions of this Section 14.16 and Article 10 and
Section 14.6, the rights and obligations of the Parties under this Agreement shall not become effective until (a) the waiting period (and any extension thereof) applicable to the transactions contemplated by this Agreement under the HSR
Act shall have expired or earlier been terminated; (b) no injunction (whether temporary, preliminary or permanent) prohibiting consummation of the transactions contemplated by this Agreement or any material portion hereof shall be in effect;
and (c) no judicial or administrative proceeding opposing consummation of all or any part of this Agreement shall be pending (the date these conditions are satisfied being the “Effective Date” of this Agreement). Upon the
occurrence of the Effective Date, all provisions of this Agreement shall become effective automatically without the need for further action by the Parties. 
 (c) If the Effective Date has not occurred within [*] after the Execution Date, or such other date as the Parties may mutually agree, this Agreement may be terminated by either Party on written
notice to the other. 
 14.17 No Third Party Rights or Obligations. No provision of this Agreement shall be deemed or
construed in any way to result in the creation of any rights or obligation in any Person not a Party to this Agreement. 

14.18 Further Actions. Each Party agrees to execute, acknowledge and deliver such further instruments, and to do all such other
acts, as may be necessary or appropriate in order to carry out the purposes and intent of this Agreement. 
 14.19
Affiliates. Each Party shall be primarily responsible for and shall guarantee the performance of its Affiliates under this Agreement. 
 [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] 

  
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[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 IN WITNESS WHEREOF, the Parties intending to be bound have caused this Agreement to be
executed by their duly authorized representatives. 
  

									
	BIOGEN IDEC MA INC.	  		  	PORTOLA PHARMACEUTICALS, INC.
					
	Signature:	  	 /s/ Douglas E. Williams
	  		  	By:	 	 /s/ William Lis

					
	Print Name:	  	Douglas E. Williams, Ph.D.	  		  	Name:	 	William Lis
	Title:	  	Executive Vice President	  		  	Title:	 	President and CEO
		  	Research & Development	  		  		 	
				
	 Address: 14 Cambridge Center
                 Cambridge, MA, 02142
	  		  		 	

 [SIGNATURE PAGE OF THE LICENSE AND COLLABORATION AGREEMENT BY AND BETWEEN 

BIOGEN IDEC MA INC. AND PORTOLA PHARMACEUTICALS, INC.] 

  
 64 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 EXHIBIT A 
 Development Plan 
  

							
	[*]	 		 		 	
	  	 	 Lead
	 	 trial start
	 	 notes

	 [*]
	 	[*]	 	[*]	 	[*]

  
 65 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 EXHIBIT B 
 Certain Indications 
 [*] 

  
 66 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 EXHIBIT C 
 Structures 
 Lead Compound existing as of Execution Date (PRT062607): 

[*] 
 Back –up Compound existing as of
Execution Date [*]: 
 [*] 

  
 67 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 EXHIBIT D 
 Portola Patents Existing as of the Execution Date 
 [*] 

 

																					
	 Ref.
 No.
	 	 Portola Dkt. No.
	 	 KTS

Ref No.
	 	 Country
	 	 Title
	 	 Status
	 	 Application Number
	 	 Application
Date
	 	 Grant
Number
	 	 Grant Date
	 	 Owner

	 [*]
	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]	 		 		 	[*]

 [*] 
  

																					
	 No.
	 	 Portola Dkt. No.
	 	 KTS

Ref No.
	 	 Country
	 	 Title
	 	 Status
	 	 Application Number
	 	 Application
Date
	 	 Grant
Number
	 	 Grant Date
	 	 Owner

	 [*]
	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]	 		 		 	[*]

 [*] 
  

																					
	 No.
	 	 Portola Dkt. No.
	 	 KTS

Ref No.
	 	 Country
	 	 Title
	 	 Status
	 	 Application
Number
	 	 Application
Date
	 	 Grant
Number
	 	 Grant Date
	 	 Owner

	 [*]
	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]	 		 		 	[*]

 [*] 
  

																					
	 No.
	 	 Portola Dkt. No.
	 	 KTS
Ref. No.
	 	 Country
	 	 Title
	 	 Status
	 	 Application
Number
	 	 Application
Date
	 	 Grant
Number
	 	 Grant Date
	 	 Owner

	 [*]
	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]	 		 		 	[*]

 [*] 
  

																					
	 No.
	 	 Portola Dkt. No.
	 	 KTS
Ref. No.
	 	 Country
	 	 Title
	 	 Status
	 	 Application
Number
	 	 Application
Date
	 	 Grant
Number
	 	 Grant Date
	 	 Owner

	 [*]
	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]	 		 		 	[*]

  
 68 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 EXHIBIT E 
 [*] Patents 
 [*] 

 

																					
	 Ref.
 No.
	 	 Portola Dkt. No.
	 	 KTS

Ref No.
	 	 Country
	 	 Title
	 	 Status
	 	 Application Number
	 	 Application
Date
	 	 Grant
Number
	 	 Grant Date
	 	 Owner

	 [*]
	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]	 		 		 	[*]

  
 69 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 EXHIBIT F 
 [*] 
 It is the Parties’ intent that, for all [*], certain of such [*] may be
[*] by the following procedures: 
 1. From time to time, Biogen Idec may propose by notice to Portola’s [*] that [*] or [*] and [*] or a
[*] for which [*] or a [*] (including [*]) (a “[*]”) be [*]. 
 2. Portola shall then consult with Biogen Idec [*], then such
[*], Portola shall [*] either that [*] or that [*]. 
 3. To the extent that [*] and [*], such [*] shall be [*]. To the extent that [*] and [*]
shall be [*], whereas [*] 
 4. The provisions of this Exhibit F shall not apply [*], or [*]. 

5. The provisions of this Exhibit F shall apply on a [*] basis, and the Parties shall share the costs incurred in connection with the activities set
forth in this Exhibit F in the same manner as set forth in Section 9.2(b). 

  
 70 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 EXHIBIT G 
 Specificity Criteria 
 [*] 

  
 71 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 EXHIBIT H 
 Transition Plan 
 With respect to Lead Compound and each of the
Back-Up Compounds, where applicable, transfer will include delivery of the following items in electronic form (including access to all applicable assays at 3rd party vendors): 

 

									
	 [*]
	 	 [*]
	 	 [*]
	  	[*]	  	[*]
	 [*]
	 	[*]	 	[*]	  	[*]	  	[*]

  
 72 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 EXHIBIT I 
 Co-Promotion Terms 
 This Exhibit sets forth material terms and conditions that,
together with the terms of Section 7.2 of the Agreement, shall be incorporated into a Co-Promotion Agreement to be negotiated and entered into by the Parties for the Product for which Biogen Idec exercises its option to Co-Promote in accordance
with Section 7.2(a) of the Agreement, or for which Portola exercises its option to Co-Promote in accordance with Section 7.2(b) of the Agreement. 
 1. Co-Promotion Rights and Obligations; Plan 
  

	(a)	General. [*] 

  

	(b)	Annual Plan. [*] 

 2. Sales Force

  

	(a)	Establishment; Early Deployment. [*] 

  

	(b)	Qualifications. [*] 

  

	(c)	Product-Specific Training. [*] 

3. Commercialization Efforts. The Co-Promotion Party shall use Commercially Reasonable Efforts to Co-Promote each Product in accordance with all
applicable laws. 
 4. Sales Effort Tracking. Portola and Biogen Idec shall [*]. The Co-Promotion Party shall maintain written and/or
electronic records of its sales efforts for a period of [*]. All information concerning such statements shall be Confidential Information of the Co-Promotion Party. 
 5. Promotional Materials and Standards. In Co-Promoting a Product, the Parties shall maintain and adhere strictly to the approved labeling of the Product, the approved marketing materials for the
Product, the Agreement and the Plan for such Product. Only marketing materials and programs developed by the lead commercialization Party’s marketing team and approved via the Co-Promotion Party’s legal review process in accordance with
FDA regulations for the Product in the United States shall be used in the United States. All promotional materials used by the Parties and all promotional activities relating to the Product shall comply with all applicable laws and the Code of
International Federation Pharmaceutical Manufacturer Association (“IFPMA”), including all FDA regulations regarding pharmaceutical marketing practices in the United States. In addition, each Party shall ensure that its representatives
Detail Co-Promoted Product in a fair and balanced manner consistent with all applicable legal, regulatory, professional and policy requirements. Biogen Idec and Portola representatives shall not engage in any pre-marketing activities for a Product
prohibited by applicable laws and shall not promote any Product for off-label uses. 
  

	6.	Sales Efforts in the United States. The lead commercialization Party shall [*]. 

  
 73 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 7. Compensation. The lead commercialization Party shall [*]. Such payment shall be made on a Calendar
Quarter basis in accordance with the Financial Exhibit. Notwithstanding the foregoing, [*]. 
 8. Sales Information Integration. Each
Party will strive to establish a transparent and compatible sales reporting system for Products to facilitate call planning and representatives activities. 
 9. Miscellaneous. The Co-Promotion Agreement shall contain other customary and appropriate provisions, including provisions for confidentiality, termination and, to the extent not already addressed
in the Agreement, indemnification. 

  
 74 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 EXHIBIT J 
 Back-Up Compound Profile 
 The “Backup Compound Profile”
requirements shall include without limitation: 
 [*] 

  
 75 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 EXHIBIT K 
 Press Release 

  
 76 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

  
 

 
  
 

 
 For More Information Contact: 
  

			
	 Biogen Idec Media Contact:
 Naomi Aoki
 Director, Public Affairs
 (781) 464-3260
  
 Portola
Media Contact:
 Paul Laland

WCG
 415-519-6610
	  	 Biogen Idec Investor Relations Contact:
 Kia Khaleghpour
 Associate Director, Investor Relations

(781) 464-2442
  
 Portola Investor Contact:
 Mardi Dier

Chief Financial Officer

650-246-7236

 BIOGEN IDEC AND PORTOLA PHARMACEUTICALS ANNOUNCE GLOBAL COLLABORATION FOR ORAL SYK INHIBITOR PROGRAM
TARGETING AUTOIMMUNE AND INFLAMMATORY DISEASES 
 — Biogen Idec to Provide Portola with $45 Million 

Upfront and Up To $508.5 Million in Milestone Payments — 
 WESTON, Mass., and SOUTH SAN FRANCISCO, Calif., October X, 2011 — Biogen Idec (NASDAQ: BIIB) and Portola Pharmaceuticals, Inc. today announced that they have entered into an exclusive,
worldwide collaboration and license agreement under which both companies will develop and commercialize highly selective, novel oral Syk inhibitors for the treatment of various autoimmune and inflammatory diseases, including rheumatoid arthritis
(RA) and systemic lupus erythematosus (SLE). 
 The collaboration’s lead molecule, PRT062607, has been shown to be a highly potent and
specific oral inhibitor of Syk in a broad panel of in vitro kinase and cellular assays and is currently in Phase 1 studies. Results of the studies to date suggest the compound is well tolerated and has a profile suitable for once-daily dosing.

 Under the terms of the agreement, Biogen Idec will provide Portola with an upfront payment of $36 million in cash and $9 million in equity,
with additional payments of up to $508.5 million 

  
 77 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
based on the achievement of certain development and regulatory milestones. Biogen Idec will lead the global development and commercialization efforts for the Syk inhibitor program in major
indications such as rheumatoid arthritis and lupus, while Portola will lead U.S. development and commercialization efforts for select smaller indications as well as discovery efforts for follow-on Syk inhibitors. Portola retains an option to
co-promote alongside Biogen Idec in the United States in major indications. Worldwide costs and profits will be split by Biogen and Portola 75% and 25%, respectively. 
 “We are enthusiastic to be working with Portola to advance its Syk inhibitor as a potential treatment for autoimmune diseases,” said George A. Scangos, Ph.D., CEO of Biogen Idec. “Portola
is a high-quality company with a great track record in small molecules, and we have crafted a collaboration that truly is a win for both companies. We will now focus on a thoughtful and aggressive program to fully explore the potential of
Portola’s compounds against this very interesting target, with the goal of creating an effective, safe and convenient oral treatment for patients with debilitating autoimmune and inflammatory diseases.” 

“A significant portion of people with rheumatoid arthritis do not respond to currently approved treatments or have only modest responses, and
treatment options for lupus are limited,” said Doug Williams, Ph.D., Executive Vice President, Research and Development of Biogen Idec. “Inhibition of Syk has the potential to provide effective, well-tolerated therapies for patients with
these and other autoimmune diseases. We are encouraged by the preclinical and clinical data to date and see an opportunity to develop a best-in-class, highly selective oral treatment for these devastating diseases. This program plays to our
strengths and experience in immunology, particularly B-cell biology, reflects our focus on cutting-edge science, and strengthens our early-stage pipeline.” 
 “This partnership is an excellent scientific and cultural fit between two biotech companies,” said William Lis, CEO of Portola. “Biogen Idec is a world-class R&D organization with a
significant global footprint and track record of success in developing and commercializing innovative autoimmune disease therapies. For Portola, the terms of this collaboration reflect the scientific advances we’ve made in the discovery of
orally available kinase inhibitors and our vision to commercialize products with clear and meaningful value. Partnering with Biogen Idec provides us with the resources and added expertise to pursue the full potential of our Syk inhibitor
program.” 
 Completion of the transaction is subject to customary closing conditions, including antitrust clearance by the US Government
under the Hart-Scott-Rodino Act. 
 About Rheumatoid Arthritis 
 RA is a chronic and debilitating autoimmune disease that occurs when the immune system inappropriately attacks joint tissue, causing painful chronic inflammation and irreversible destruction of cartilage,
tendons and bones. RA often results in chronic pain, loss of function and disability and can also lead to cardiovascular and pulmonary complications. About 1.3 million Americans suffer from RA, according to the Arthritis Foundation. Worldwide,
the disease is believed to affect more than 23 million people, according to the World Health Organization. 

  
 78 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 About Systemic Lupus Erythematosus (SLE) 
 Systemic lupus erythematosus is a chronic autoimmune disease that occurs when the immune system malfunctions and attacks and destroys healthy tissues and organs. It can damage many different parts of the
body, including skin, joints or organs, resulting in symptoms such as inflammation, pain, extreme fatigue and anemia. These symptoms can make managing even routine daily activities difficult, and in severe cases, the disease can be life-threatening.
Nearly 1.5 million Americans and 5 million people worldwide suffer from lupus, according to the Lupus Foundation of America. 

About Biogen Idec 
 Biogen Idec uses
cutting-edge science to discover, develop, manufacture and market therapies for serious diseases with a focus on neurology, immunology and hemophilia. Founded in 1978, Biogen Idec is the world’s oldest independent biotechnology company.
Patients worldwide benefit from its leading multiple sclerosis therapies, and the company generates more than $4 billion in annual revenues. For product labeling, press releases and additional information about the company, please visit
www.biogenidec.com. 
 About Portola Pharmaceuticals, Inc. 
 Portola Pharmaceuticals discovers and develops innovative therapeutics based on targets with established proof of concept that are designed to provide significant advances over current treatments for
cardiovascular and autoimmune/inflammatory diseases. Portola scientists have successfully collaborated for over 15 years on the discovery and development of novel small molecule agents targeting platelets, coagulation pathways and protein kinases.
In thrombosis, Portola is independently developing betrixaban, a Phase 3-ready, long-acting, oral direct Factor Xa inhibitor, and its companion product, PRT064445, a recombinant Factor Xa inhibitor antidote. In inflammation, the company is
collaborating with Biogen Idec to develop PRT062607, an oral Syk-specific kinase inhibitor. In addition to the Syk clinical programs, Portola’s broad chemistry capability has led to the discovery of potent, oral specific inhibitors of Janus
Kinase (JAK), as well as dual inhibitors of Syk and JAK for chronic autoimmune indications and oncology. Portola is currently in a partnership with Novartis Pharma AG to develop elinogrel, a Phase 3-ready antiplatelet that is a direct-acting,
competitive and reversible i.v. and oral P2Y12 ADP receptor antagonist. For additional information, visit www.portola.com. 
 Safe Harbor

 This press release contains forward-looking statements, including statements about product development and commercialization. These
forward-looking statements may be accompanied by such words as “anticipate,” “believe,” “estimate,” “expect,” “forecast,” “intend,” “may,” “plan,” “will” and
other words and terms of similar meaning. You should not place undue reliance on these statements. Drug development and commercialization involve a high degree of risk. Factors which could cause actual results to differ materially from our current
expectations include the risk that adverse safety events may occur, regulatory authorities may require additional information or may fail to approve any potential new therapy, reimbursement for our products may be limited or unavailable, we may
encounter problems with our manufacturing processes, we may be unable to adequately protect our intellectual property rights, and the other risks and uncertainties that are described in the Risk Factors section of our most recent annual or quarterly
report and in other reports we have filed with the SEC. These statements are based on 

  
 79 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
our current beliefs and expectations and speak only as of the date of this press release. We do not undertake any obligation to publicly update any forward-looking statements. 

### 

FINANCIAL EXHIBIT 
 Financial Planning, Accounting and Reporting Procedures 
 This
Financial Exhibit sets forth the principles for reporting actual results and budgeted plans in the Territory, the frequency of reporting, the use of a single Functional Currency (as defined in Section A.3 of this Exhibit) and the methods of
determining payments to the Parties, auditing of accounts and other matters. 
 This Financial Exhibit provides agreed
upon definitions of financial terms applicable to the Parties for purposes of the Agreement. All capitalized terms used herein without definition shall have the meanings ascribed thereto in the Agreement and, where applicable, the further
definitions contained herein. References in this Financial Exhibit to a “Party” or “Parties” shall be construed to mean Biogen Idec or Portola, as the case may be, and in every case shall be deemed to include
a Party’s Affiliates or sublicensees under the Agreement. 
 Notwithstanding anything in the Agreement to the contrary, no
cost, expense, amount or sum allocable or chargeable to the Parties’ activities under the Agreement shall be allocated or charged more than once. Unless otherwise specifically authorized by the Parties or the Agreement, all costs, expenses,
amounts or sums to be charged or allocated by one Party to the other Party under the Agreement shall not be so chargeable or allocable unless [*]. 
  

	A.	Definitions, Reporting and Reconciliation 

 A.1. Definitions 
 “Collaboration Budget” shall include
all revenues and the expenses as further defined herein incurred by Biogen Idec and Portola necessary to support the research, development, and commercialization of the Product. The Collaboration Budget shall include [*]. 

“Collaboration Operating Profit” means the profits or losses resulting from the Commercialization of Products in the
Profit Share Territory and shall be equal to [*]. In the event the Product is a Combination Product, the Collaboration Operating Profit shall be calculated as follows: [*]. 
 “Combination Product” shall mean a product containing both a Product and one or more other active ingredients in addition to such Product where the other active ingredients have
independent prophylactic or therapeutic effect when used alone to treat the disease or indication for which the Combination Product is labeled, whether such Product and the other active ingredients are together in a physical mixture or packaged and
priced together as a single product. 
 “Combination Product Amount” shall mean the following: in the event a
Product is sold in the form of a Combination Product, and provided that the JSC has approved the sale and marketing of such a Combination Product in a Commercialization Plan, Net Sales for such Combination Product for purposes of determining Biogen
Idec’s payment obligations under Section 8.4 (but not Section 8.3) will be determined by multiplying Net Sales of such Combination Product by the fraction A/(A + B), where A is the average prior year’s annual

  
 80 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
invoice price of the Product, if sold separately, and B is the average prior year’s annual invoice price of any other active component or components in the combination, if sold separately,
in each case in the same country and in the same dosage as in the Combination Product. If, on a country-by-country basis, the other active component or components in the combination are not sold separately in such country, Net Sales shall be
calculated by multiplying actual Net Sales of such Combination Product by the fraction A/C where A is the average prior year’s annual invoice price of the Product if sold separately, and C is the average prior year’s annual invoice price
of the Combination Product, in each case in the same country and in the same dosage as in the Combination Product. If, on a country-by-country basis, the Product component of the Combination Product is not sold separately in such country, but the
other active component or components are sold separately, Net Sales shall be calculated by multiplying Net Sales of such Combination Product by the fraction (C-B)/C where B is the average prior year’s invoice price of the other active component
or components, if sold separately, and C is the average prior year’s invoice price of the Combination Product, in each case in the same country and in the same dosage as in the Combination Product. If, on a country-by-country basis, neither the
Product nor the other active component or components of the Combination Product is sold separately in such country, Net Sales for such Combination Product shall be determined by the Parties in good faith. If there are no prior year’s invoices,
the Parties may use an estimate of future invoice prices. In any event, the percentage of the Net Sales of the Combination Product attributable to the Product shall not be less than [*]. 

“Cost of Clinical Supplies” shall mean [*] which will be determined in accordance with GAAP, excluding [*]. 

“Cost of Goods Manufactured for Sale” or “COGM” shall mean a Party’s costs to produce or acquire
clinical supplies and/or commercial supplies of a Product to the extent that [*]. This definition shall exclude [*]. 

“Cost of Sales” shall mean a Product’s [*]. 

“Development Expenses” shall mean the costs and expenses associated with Development activities for each Product
incurred by Biogen Idec or Portola or their Affiliates from the Effective Date through the later of [*]. The costs and expenses associated with Development activities shall include [*]. Development Expenses shall also include, but are
not limited to, [*]. Development Expenses shall also include [*]. In determining Development Expenses chargeable under this Agreement, each Party will [*]. The Parties shall agree upon and consistently apply [*]. The Parties hereby
agree that efforts of the employees of a Party or its Affiliates in performing its activities hereunder shall be [*]. Notwithstanding anything in this Section to the contrary, [*]. All payments made by a Party to a Third Party in
connection with the performance of its activities under the Development Plan and Collaboration Budget shall be [*]. The Cost of Clinical Supplies shall be [*]. Except to the extent included in Cost of Clinical Supplies, [*]. 

“Distribution Costs” shall mean the FTE costs and other costs specifically identifiable or allocable to the distribution
of Product including [*]. The FTE Costs related to Distribution Costs will be set as part of the annual budgeting process and will be calculated using [*]. The [*] will include [*]. For clarity, Distribution Costs shall not include [*].

  
 81 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 “FTE” shall mean a total of [*] on the Development, manufacturing or
commercialization of a Product carried out by employees of a Party having the appropriate relevant expertise to conduct such activities. 
 “FTE Costs” shall equal the number of relevant FTEs multiplied by the applicable FTE rate. 
 “Gross Sales” shall mean the gross amount invoiced by a Party or its Affiliates or sublicensees for sales of a Product to unrelated Third Parties in bona fide arms length transactions in
the Territory, including [*]. For clarity, Gross Sales will include [*]. A sale or transfer of a Product by a Party to one of its Affiliates shall not be considered a sale to a Third Party for the purpose of this provision but the resale of such
Product by such Affiliate to a Third Party shall be a sale for such purposes. In the event the Product is sold in the form of a Combination Product, for the purpose of determining Biogen Idec’s payment obligation under Section 8.3 (but not
Section 8.4), Gross Sales will be the Combination Product Amount. [*] 
 “Marketing Costs” shall
mean the FTE costs and other direct costs of marketing, promotion and advertising, including, without limitation, [*]. “Marketing Costs” shall also include activities related to [*]. For purposes of this definition, FTE costs
shall be [*]. Marketing costs will specifically exclude [*]. 
 “Medical Education Costs” means costs designed
to [*]. 
 “Net Sales” shall mean Gross Sales of a Product less applicable Sales Returns and Allowances.

 “Ongoing Development Expense” shall mean FTE costs and other costs and expenses borne by either Party or its
Affiliates with respect to Phase IV Clinical Trials approved by the JSC. For purposes of this definition, FTE Costs shall be [*]. 
 “Operating Expenses” shall mean [*]. 
 “Other
Out-of-Pocket Costs” shall mean other operating expenses paid by the Parties or their Affiliates to Third Parties which are not part of Development Expenses, but are considered and approved by the JSC as expenses for purposes of the cost
sharing arrangements under the Agreement. Other Out-of-Pocket Costs shall be limited to the following: 
  

	 	•	 	 [*] 

 “Patent Expenses” means the sum of all out-of-pocket expenses reasonably incurred by a Party to prepare, file, prosecute and maintain Portola Patents, Biogen Idec Patents and Joint
Patents, including the costs of interferences/oppositions proceedings with respect to such Patent Rights. In addition, Patent Expenses shall include [*]. 
 “Phase IV Clinical Trial” means any clinical trial in an Indication to be conducted after a Regulatory Approval in such Indication which was mandated by the applicable Regulatory
Authority as a condition of such Regulatory Approval. 

  
 82 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 “Post-Approval Clinical Trial” shall mean any clinical trial in an
Indication, other than a Phase IV Clinical Trial, to be conducted after a Regulatory Approval for such indication. 

“Sales Costs” shall mean FTE costs and other direct costs approved by as part of the Collaboration Budget and
specifically identifiable to sales of Products in the Territory. Sales Costs shall include [*]. 
 “Sales
Returns & Allowances” shall mean [*]. 
 It is the intention of the Parties that the interpretation of
these definitions in this Financial Exhibit will be in accordance with GAAP consistently applied in accordance with Biogen Idec then current practices. A Party will promptly make the appropriate adjustments to the financial information it
supplies under the Agreement to reflect changes to the provisions, including reasonable detail underlying the adjustment, in reporting results of operation. 
 “Sales & Royalty Report” means a written report or reports showing on a country-by-country basis each of: [*]. 

A.2. Collaboration Budget and Quarterly Updates 
 First Collaboration Budget. As soon as practical following the Effective Date, Biogen Idec and Portola will prepare a Collaboration Budget for the Development Plan for 2011 and 2012, specifying in
detail the activities to be performed during the year, staffing levels, and any approved use of Third Party contractors. 

Yearly Updates. Biogen Idec and Portola shall, on an annual basis, shall prepare a Budget which shall specify in detail
[*]. Budgets will contain monthly details/numbers. Budgets will be supplemented with high level business plans and costs for [*]. Each update to the budget under this paragraph and any modifications per the Quarterly Budget updates
outlined below shall [*]. Collaboration Budgets will contain monthly details/numbers. Collaboration Budgets will be supplemented with high level business plans and costs for [*]. 

Quarterly Collaboration Budget Updates. (Also referred to as a “Quarterly Forecast.”) Biogen Idec and Portola
shall revise the Collaboration Budget on a quarterly basis during the course of each year based on [*]. 

Sales & Royalty Forecast upon Exercise of the Opt-out Option. Upon exercise by Portola of its Opt-Out Option, Biogen Idec
shall continue to provide to Portola a current calendar year Sales & Royalty Forecast that shows country-by-country projections of: [*]. 
 A.3. Reporting 
 Reporting. Each Party shall report to the other
Party Quarterly Forecasts and actual results of operations related to the following categories: 
  

	 	•	 	 [*] 

Reporting by each Party will be performed as follows: 

  
 83 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

					
	 Reporting Event
	  	Frequency	 	Timing of Submission
	 [*]
	  	[*]	 	[*]
	 [*]
	  	[*]	 	[*]
	 [*]
	  	[*]	 	[*]
	 [*]
	  	[*]	 	[*]
	 [*]
	  	[*]	 	[*]
	 [*]
	  	[*]	 	[*]

 The financial representatives from the Parties will review financial information monthly and meet as
appropriate but shall in any event meet at least quarterly with at least one in person meeting annually to review and approve the following: 
  

	 	•	 	 [*] 

Reconciliation Statements. Within [*] following the end of a Calendar Quarter, each Party shall submit to the other Party a
Pre-Reconciliation Report encompassing[*]. Within [*] following the end of a Calendar Quarter, each Party shall submit to the other Party its report of actual results as outlined above. Expenses charged by either Party shall not [*].
If the actual costs of implementing a Collaboration or the Development Plan are expected to vary by more[*]than [*] from the amounts budgeted for expenditure during the calendar year, the Responsible Development Party will promptly revise, as
applicable, the Collaboration Budget or Development Plan and submit it in writing, with an explanation of the variance and the reasons therefore, for approval to the JSC. If the JSC does not approve the variance, the amount by which the actual costs
exceed [*] 
 The financial representatives from each Party shall be responsible for, within [*] following
the end of a Calendar Quarter, preparing a statement (“Reconciliation Statement”) in a format agreed to by the Parties showing [*]. The Reconciliation Statement and reports of actual results compared to budget will be sent to
each party within[*] following the end of a Calendar Quarter for approval. Each party shall provide notice of approval or disapproval of the Reconciliation Statement within [*] of receipt. If both parties approve, the Reconciliation Statement
will be sent to the JSC for its information. If either party disapproves, within [*] after receipt of the Reconciliation Statement the JSC shall meet to approve or otherwise resolve the Reconciliation Statement. Reconciliation Statements
shall be made by Portola or Biogen Idec in the manner set forth in Section Y (section titled “Payments Between Parties” of this Financial Exhibit.] 

  
 84 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 Development Expense Reporting after Opt-Out Option is exercised. After Portola
exercises its Opt-Out option, pursuant to 4.5 (b), Portola shall provide Biogen IDEC reports of [*] on a quarterly basis within [*] after the end of the Calendar Quarter. Within [*] after receiving such report from Portola,
[*]. 
 Foreign Exchange. The “Functional Currency” for accounting for Ongoing Development
Expenses, Other Out-of-Pocket Costs and Development Expenses will be U.S. dollars. Except as the Parties otherwise mutually agree, for billing and reporting, the statement of operations will be translated into U.S. dollars. All payments to be made
by Biogen Idec to Portola or from Portola to Biogen Idec under this Agreement shall be made in United States dollars by bank wire transfer in immediately available funds to a bank account in the United States designated in writing by Portola and
Biogen Idec. In the case of sales outside the United States, the rate of exchange to be used in computing the monthly amount of currency equivalent in United States dollars due Portola or Biogen Idec shall be [*]. 

A.4. Audits and Interim Reviews. Either Party shall have the right to request that a nationally recognized, independent accounting
firm perform an audit or interim review of the other Party’s books and records as they relate to activities under this Agreement in order to express an opinion regarding such Party’s accounting for revenues, costs and expenses under this
Agreement. Such audits or review will be conducted at the expense of the requesting Party. Upon [*] prior written notice from a Party (the “Auditing Party”), the other Party (the “Audited Party”) shall permit the
mutually agreed upon independent accounting firm to examine the relevant books and records of the Audited Party and its Affiliates as may be reasonably necessary to verify the reports and information submitted by the Audited Party and the accuracy
of any Reconciliation Statement. An examination by a Party under this Section shall [*] and shall be limited to the pertinent books and records for any calendar year ending not more than [*] before the date of the request. The accounting firm shall
be provided access to such books and records at the Audited Party’s facility(ies) and/or the facilities of its Affiliates or sublicensees where such books and records are normally kept and such examination shall be conducted during the Audited
Party’s normal business hours. The Audited Party may require the accounting firm to sign a standard non-disclosure agreement with terms that are not inconsistent with the terms of the Agreement before providing the accounting firm access to the
Audited Party’s facilities or records. Upon completion of the audit, the accounting firm shall provide both Biogen Idec and Portola a written report disclosing whether the reports submitted by the Audited Party are correct or incorrect and the
specific details and supporting analysis for any discrepancies. No other information shall be provided to the Auditing Party. If the accounting firm determines that, based on errors in the reports so submitted, any report prepared in accordance with
the Agreement is incorrect, the Parties shall promptly revise the report and the associated Reconciliation Statement and any additional amount owed by one Party to the other shall be paid within [*] after receipt of the accountant’s report,
along with interest at the lesser of (i) the annualized interest rate at [*] or (ii) the highest rate permitted by applicable law from the date that such additional amount should have first been paid; provided,
however, that [*]. Additionally, if the accountant determines that the reports submitted by the Audited Party overstate the Audited Party’s share by more than [*], the Audited Party shall reimburse the Auditing Party for
the expenses incurred by the Auditing Party in conducting the audit. Notwithstanding anything to the contrary herein, the Parties shall coordinate with their Affiliates such that [*] with respect to the development, manufacturing, commercialization
or other use of 

  
 85 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 
the Product under any written agreement between the Parties and/or their Affiliates relating to the Product. In the event of any sublicense or transfer of rights with respect to Products by a
Party under this Agreement, the sublicensor or transferor shall provide for audit rights by the other Party to this Agreement. 

A.5. Payments Between the Parties. Based upon the Reconciliation Statement as approved by the JSC there shall be a cash settlement
between the Parties no later than [*] after the end of each Calendar Quarter. In the event any payment is made after the date specified in the preceding sentence and provided that such payment is not otherwise subject to good faith dispute,
the paying Party shall increase the amount otherwise due and payable by adding interest at the lesser of (i) the annualized interest rate at [*], as reported in the Wall Street Journal, Eastern Edition, on the due date (or, if the due
date is not a business day, on the last business day prior to such due date); or (ii) the highest rate permitted by applicable law from the date that such additional amount should have first been paid. Any other amount owed by one Party to the
other Party under this Agreement, except for amounts pursuant to Reconciliation Statements, that is not paid within the applicable time period set forth herein shall bear also simple interest at the lesser of [*] as determined above.

 A.6. FTE Methodology 
 Tracking of FTE Costs 
 Each Party shall report Operating Expenses based on
its project cost system (which shall in any event track FTEs by functional area and by month) or using such other system as such Party applies with respect to its internal programs. In general, these project cost systems shall report actual and/or
allocable time spent on specific projects, apply the appropriate FTE rates, capture actual and/or allocable costs of specific projects and allocate other expenses to projects. 
 Total budgeted expenses incorporated in the FTE rate shall include: [*]. 

R&D FTE Costs. For the remaining calendar year 2011, the FTE rate will be set at [*]. This FTE rate shall apply to the
FTE Costs related to Development Expenses, and Ongoing Development Expenses. The R&D FTE rate will increase annually (with the first of such increase commencing on January 1, 2013) to reflect the change over the preceding twelve
(12) months for which data is then available in the Consumer Price Index in the Urban Consumers (CPI-u): US City Average, All Items (as published by the United States Department of Labor, Bureau of Statistics). 

FTE Costs related to [*] will be set as part of the annual budgeting process and will be calculated using [*]. The
[*] will include [*]. During this process [*] will be further stratified to include the following categories: [*]. 
 A.7. Principles of Reporting 
 The results of operations of the will be
presented in the following format (on a per Product basis), with the categories as defined in Section A.1 above: 

  
 86 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 Income Statement 

[*] 
 It
is the intention of the Parties that the interpretation of these definitions will be in accordance with GAAP. 
 Reports;
Payment of Royalty. During the Term, following the First Commercial Sale of a Product, Biogen Idec shall furnish to Portola a quarterly Sales & Royalty Report and the following information for Portola to fulfill its reporting obligation
to Astellas: [*]. Reports shall be due on the [*] following the close of each Calendar Quarter. Royalties shown to have accrued by each royalty report shall be due and payable on the date such royalty report is due. Biogen Idec shall
keep complete and accurate records in sufficient detail to enable the royalties payable hereunder to be determined. 

  
 87 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 

 SCHEDULE 1 

 

							
	 Material Transfer Agreements

	  	  	Institution	 	Principal Investigator	 	Agreement Date
	 [*]
	  	[*]	 	[*]	 	[*]

  
 88 

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended.

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