Document:

EX-4.4

 Exhibit 4.4 
  

 
 Dated 16 December 2017 

GLAXOSMITHKLINE LLC 
 and

 HAL V. BARRON 

SERVICE AGREEMENT 

 This Agreement is made on 16 December 2017 between: 

 

	(1)	 GLAXOSMITHKLINE LLC whose trading office is at Five Crescent Drive, Philadelphia, Pennsylvania 19112,
USA (the “Company”); and 

  

	(2)	 HAL V. BARRON of 315 Clipper Street, San Francisco, CA 94114, USA (the “Executive”).

  

	1	 Interpretation 

 

	 	1.1	 In this Agreement (and any schedules to it) 

“Accrued Obligations” means: 
  

	 	1.1.1	 the Executive’s base salary under this Agreement through to the end of the month in which the Termination
Date occurs at the rate in effect on the Termination Date and the reimbursement (in accordance with Group policy) of any expenses incurred by the Executive prior to the Termination Date; 

 

	 	1.1.2	 any unpaid bonus pertaining to the previous financial year and the product of any target bonus for the
financial year in which the Termination Date occurs and a fraction, the numerator of which is the number of days in the Company’s current financial year up to the Termination Date and the denominator of which is 365, paid as soon as practicable
on or following the termination date; 

  

	 	1.1.3	 any remuneration previously deferred by the Executive (together with any accrued interest) and not yet paid by
the Company including payment for any accrued vacation not taken by the Executive, in each case paid in accordance with the applicable plan, policy or program of the Company; and 

 

	 	1.1.4	 any other benefits to which the Executive is entitled, as determined in accordance with the applicable plans
and policies of the Company; 

 “Agreement” means this employment agreement, which as of the date hereof
supersedes and replaces any previous employment agreement between the Company and the Executive; 
 “Board” means the board
of directors of the Company from time to time or any person or committee nominated by that board as its representative for the purposes of this Agreement; 

“Chief Executive Officer” means the Chief Executive Officer of GSK plc from time to time; 

“Employment” means the employment governed by this Agreement; 

“Group” means the Company and any other Company controlling, controlled by or under the direct or indirect common control of
the Company, including, without limitation, GSK plc and any of its subsidiaries from time to time; 
 “Group Company” means
a member of the Group and “Group Companies” will be interpreted accordingly; 
 “GSK Board” means the board
of directors of GSK plc from time to time or any person or committee nominated by the GSK Board as its representative for the purposes of this Agreement; 

“GSK plc” means GlaxoSmithKline plc; 

“Termination Date” means the date on which the Employment terminates pursuant to this Agreement. 

 

	 	1.2	 References to any statutory provisions include any modifications or re-enactments of those provisions.

  

	 	1.3	 In this Agreement terms used in the context of the GlaxoSmithKline Performance Share Plan shall have the
meaning ascribed to them in such plan. 

  

	2	 Employment 

The Company confirms the Employment of the Executive, and the Executive confirms his Employment with the Company, on the terms and conditions
set out in this Agreement. 

  
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	3	 Termination by Notice 

 

	 	3.1	 The Employment under the terms of this Agreement shall be deemed to have commenced on 1 January 2018, and
the Employment shall continue until: 

  

	 	(i)	 the Employment is otherwise terminated in accordance with this Agreement; or 

 

	 	(ii)	 not less than 12 calendar months’ notice in writing is given by the Company to the Executive; or

  

	 	(iii)	 not less than 12 calendar months’ notice in writing is given by the Executive to the Company; and, in any
event, 

  

	 	(iv)	 at no point beyond 31 December 2024. In the event that this Agreement shall terminate pursuant to this
Clause 3.1(iv), then the Executive shall thereafter be deemed an employee “at will” and shall be entitled only to payment of Accrued Obligations. 

  

	 	3.2	 The Company may, in its absolute discretion, lawfully terminate the Employment of the Executive at any time,
with immediate effect and without cause, by paying in aggregate to the Executive within 30 days of the date notice of termination is given to him a sum equal to his base salary (excluding any other benefits) for the period this Agreement would
otherwise continue following such notice (not to exceed the maximum period of 12 months). For this purpose, salary shall be the base salary in effect at the date of termination of the Employment. 

 

	4	 Duties and Responsibilities 

 

	 	4.1	 The Executive shall be appointed as Chief Scientific Officer and President R&D. The Executive will be
compensated at GSK grade 0. The Executive shall have such powers and duties as are from time to time given to him by the Chief Executive Officer or, if different, the person to whom the Executive reports, consistent with the Employment and this
Agreement. 

  

	 	4.2	 During the Employment, the Executive shall devote his full business time and energies to the business and
affairs of the Company and GSK plc, consistent with any other duties and responsibilities he may have to any Group Companies. The Executive’s time shall be allocated among the Group Companies in accordance with the Executive’s reasonable
judgment and dependent upon the level of his responsibilities to any other Group Company, subject to the overall supervision and direction of the Chief Executive Officer or, if different, the person to whom the Executive reports.

  

	 	4.3	 The Executive shall not, without the prior written consent of the GSK Board, accept directorships, trusteeships
and other appointments (other than of Group Companies) or carry on or be engaged, concerned or interested either directly or indirectly in any other business or for profit activity. A list of the directorships and outside interests of the Executive
approved by the GSK Board as at the date of this Agreement is attached as Appendix 1 to this Agreement. Any fees earned by the Executive in respect of such authorised activities may be retained by the Executive. 

 

	 	4.4	 While the location of the Executive’s activities shall be in or around San Francisco, CA subject to the
overall supervision and direction of the Chief Executive Officer, in order to perform properly his duties, he will be required to undertake travel elsewhere in the world and in particular to the UK and Pennsylvania where the Company maintains its
primary R&D centers. The Executive is required to reside at a location convenient to the Company’s offices in or around San Francisco, CA (or such other location as the Company may determine) during the Employment. 

 

	5	 Salary, etc. 

  

	 	5.1	 In consideration of the services to be rendered by the Executive and the promises and covenants made by the
Executive under this Agreement, specifically including Section 16, the Executive shall be paid a base salary at the rate of $1,700,000 per annum payable in accordance with the Company’s pay practices for its executives from time to time in
force (but not less frequently than calendar monthly). The salary will be credited to the Executive’s bank account notified to the Company for the purpose or paid to Executive in check or cash or another manner compliant with applicable law.
Salary shall be reviewed annually in accordance with the Company’s normal administrative practices for its executives and may be increased (but not reduced) by the Company by such amount (if any) as it shall think fit. 

  
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	 	5.2	 The Executive shall be eligible, subject to Section 6.4, to participate: 

 

	 	(i)	 in all such cash bonus plans and programmes as are made available from time to time for executives of the
Company generally of the same grade in the relevant jurisdiction in accordance with the Company’s policy (or GSK plc’s policy, as applicable); and 

  

	 	(ii)	 in respect of the salary provided by Section 5.1, in such incentive programmes as are made available from
time to time for executives of the Company and/or GSK plc generally who are of the same grade in the relevant jurisdiction, 

in each case, subject to the terms and conditions of such bonus plans and programmes from time to time in force. Any grant of share options or
awards of performance shares under such plans and programmes shall be granted subject to performance conditions as determined by the GSK Board. The Executive’s future participation in certain of these plans and programmes may be affected if the
Executive does not satisfy the Share Ownership Requirements (as amended from time to time). It is agreed that in the event the Executive leaves the Company, the Executive will retain the relevant number of shares (as set out in the Share Ownership
Requirements) until at least one year after the Termination Date. The Executive’s salary under Section 5.1 of this Agreement shall be inclusive of any fees or other remuneration to which the Executive may be entitled or receives as a
Director, alternate Director, specialist adviser, consultant or by virtue of any other office or appointment in any Group Company. The Executive shall account to the Company for all such fees or other remuneration by paying over or procuring to be
paid over the same to the Company. 
  

	 	5.3	 No Group Company shall be liable for any costs or expenses, including any costs or expenses pertaining
to travel undertaken by the Executive, incurred as a result of any activity or participation in any role or capacity external to and unrelated to the Group. It is agreed that the Executive will promptly reimburse the Company against any such costs
that may be incurred by the Group. Further, the Executive authorises the Company at any time to deduct from his salary, or any other monies payable to him by the Company, all sums which he owes the Company. If this is insufficient, the Company will
require repayment of the balance. 

  

	6	 Expenses and other Benefits 

 

	 	6.1	 The Company shall promptly reimburse to the Executive all reasonable travel and other out of pocket expenses
properly incurred by him in the performance of his duties under the Employment. The Executive will submit claims for expense reimbursement to the Company regularly with appropriate supporting documentation, and in accordance with the Company’s
policies in effect from time to time. 

  

	 	6.2	 The medical benefit arrangements for the Executive and his family are as set out in the GlaxoSmithKline
Executive Medical Plan (as amended from time to time). Details, including eligibility criteria, are set out in the TotalReward section on Connect GSK. 

  

	 	6.3	 The Company at its expense shall provide the Executive with other benefits provided to executives of the
Company of the same grade, and the Executive shall be eligible to participate in all benefit plans, practices and policies as are made available by the Company from time to time to its executives generally of the same grade subject to their terms
and conditions from time to time in force. A list of all plans and programmes currently in operation is set out in Appendix 2. Details of the relevant plans and programmes are set out in the TotalReward section on Connect GSK.

  

	 	6.4	 The Company (and GSK plc, as applicable) reserves the absolute right and discretion to amend, modify or
terminate all such benefits, plans and programmes as are referred to in Sections 5.2, 6.2, 6.3 and 8 at any time and for any reason. 

  

	7	 Vacation 

In addition to all Company Holidays, the Executive shall be entitled to 20 days’ vacation in each year at full pay, which shall accrue
rateably during the calendar year in accordance with Company policy as in effect from time to time, to be taken at such times as the business of the Company may permit. On termination of the Employment the Executive will be entitled to be paid for
any accrued vacation not taken and will reimburse the Company for any vacation taken but not accrued in accordance with the terms of Company policy as in effect from time to time. 

  
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	8	 Pension and Life Insurance 

The Executive shall be eligible to participate in the GlaxoSmithKline Cash Balance Pension Plan and any other retirement plans or deferred
compensation programmes made available by the Company to its senior executives in the United States, including, without limitation, the GlaxoSmithKline Retirement Savings Plan and the GlaxoSmithKline Executive Supplemental Savings Plan, subject to
the terms and conditions of such programmes from time to time in force. Details of such current plans and programmes are accessible from the intranet site “Connect GSK” and they are subject to amendment or withdrawal at the Company’s
discretion. 
  

	9	 Illness and Leave of Absence 

 

	 	9.1	 The Executive shall comply with the Company’s leave of absence policies from time to time in force.

  

	 	9.2	 The Executive shall be eligible to participate in the Company’s short-term and long-term disability plans
or programmes in force from time to time. 

  

	 	9.3	 If the Company has concerns about the Executive’s ability to perform the essential functions of his
role, the Company may require the Executive to have a medical examination every year (or at such shorter intervals as they may agree between them), by a doctor approved by the Company. The costs of such examinations shall be borne by the Company.
The Executive agrees and understands that this provision is job related and consistent with business necessity of the Company. 

  

	10	 Inventions and Copyright 

The Company’s Standard US Policy Requirements on Inventions, Copyright, and Confidentiality shall apply to the Executive. The
Company’s current policy language is attached as Appendix 3, which is incorporated by reference into this Agreement. The Executive expressly acknowledges and agrees to the terms, conditions, and promises contained in Appendix 3. 

 

	11	 Confidentiality; Company Securities 

Without prejudice to any other duty owed to the Company or to any Group Company, the Executive shall not, except in the proper performance of
his duties or as authorised by the Board, during or after the Employment, use, retain, or disclose to any person any Confidential Information (defined below) obtained or created by him during the Employment. 

 

	 	11.1	 In the course of the Employment, the Executive will obtain trade secrets and confidential information belonging
to or relating to Group Companies and other persons. He will treat such information as if it falls within the terms of Section 11 and Section 11 will apply with any necessary amendments, to such information. If requested to do so by the
Company, the Executive will enter into an agreement with other Group Companies and any other persons in the same terms as Section 11 with any amendments necessary to give effect to this provision. 

 

	 	11.2	 For the purposes of this Agreement, the term “Confidential Information” shall include, but not
be limited to confidential commercial, financial and strategic data pertaining to the Group and any other confidential information relating to the business or affairs of the Group including, without limitation, any invention, trade secret,
manufacturing process or patent information. The term “Confidential Information” shall not include any information: 

  

	 	11.2.1	 which is or becomes generally available to the public, or 

 

	 	11.2.2	 which is acquired by the Executive apart from his association with the Group 

 

  
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 other than, in each case, as a result of disclosure by the Executive or by any person to
whom he has supplied information or by any person in breach of a duty of confidentiality. In addition, the term “Confidential Information” shall not include any information which the Executive is required to disclose by applicable law or
regulation or by order of a court or governmental body of competent jurisdiction. 
  

	 	11.3	 During the Employment, the Executive shall be bound, in respect of transactions in securities issued by any
Group Company, by the Company’s and GSK plc’s policies from time to time in effect on employee securities dealing. In particular, the Executive shall advise the Company Secretary, Chief Financial Officer, Chief Executive Officer or
Chairman of GSK plc before he or any member of his immediate family seeks to trade in such securities and shall be bound by any directions given by the Company Secretary, Chief Financial Officer, Chief Executive Officer or Chairman.

  

	12	 General Termination Provisions 

 

	 	12.1	 On the termination of the Employment for whatever reason, or at any other time when requested to do so by the
Company, the Executive, upon receipt of written request from the Company, shall promptly: 

  

	 	(i)	 deliver up to the Company any property belonging to the Company or any other Group Company which may be in his
possession or under his control including Confidential Information, lists of customers, correspondence, documents and other property. The Executive will not retain any copies of any materials or other information. The Company shall promptly return
to the Executive and permit him to remove from the premises of the Company and any other Group Company, any property, personal records, files, etc. belonging to the Executive; and 

 

	 	(ii)	 resign on request by the Company or the GSK Board (if he has not already done so) from all offices held by him
in the Company and any other Group Company (except for any he is entitled to retain under any separate agreement with any Group Company), failing which the Executive irrevocably authorises the Company or GSK plc to appoint an officer of the Company
or GSK plc to execute all documents on his behalf and do all things necessary to effect such resignations; PROVIDED, however, that any such resignations pursuant to this Section 12.1(ii) shall be without prejudice to the Executive’s rights
under this Agreement. 

  

	 	12.2	 Any termination of the Employment shall be without prejudice to the Executive’s and the Company’s
continuing obligations under this Agreement. 

  

	 	12.3	 Upon the termination of the Executive’s Employment for whatever reason, the Executive shall immediately
repay all outstanding debts or loans due to the Company or any Group Company. 

  

	 	12.4	 The terms of the US GSK Severance Pay Plan or any other severance policy as in force from time to time, shall
not apply to the Executive. 

  

	13	 Termination due to Death or Inability to Perform Essential Functions 

 

	 	13.1	 In the event of the Executive’s death the Employment will terminate automatically on the date of his
death, which shall be the Termination Date for the purposes of this Agreement. His duly qualified executor shall be entitled to receive the Accrued Obligations. 

 

	 	13.2	 The Company may elect to terminate the Employment immediately without advance notice or payment in lieu of
notice by serving written notice, if an independent physician mutually agreeable to the Company and Executive has certified in writing that the Executive is unable to perform the essential functions of his role with or without reasonable
accommodation and will not, to a reasonable degree of medical certainty, be able to resume performance of the essential functions of his duties with or without reasonable accommodations for the foreseeable future. The Executive hereby acknowledges
and agrees that this provision is job related and consistent with business necessity, and that it would be an undue hardship for the Company to maintain the Employment under such circumstances. The Employment will terminate on the Termination Date
specified in the Termination Notice. 

  
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	 	13.3	 In the event the Company delivers a Termination Notice under 13.2, the Executive shall immediately be relieved
from all offices, appointments and responsibilities that he may then hold under the Employment and be relieved of any duty to work for or serve the Company or any Group Company. The Executive hereby acknowledges and agrees that this provision is job
related and consistent with business necessity, and that it would be an undue hardship for the Company to maintain any of the Executive’s offices, appointments, or responsibilities under such circumstances. The Executive shall be entitled only
to the Accrued Obligations, together with such rights as are provided for in the applicable benefits plan(s) in which the Executive participates. 

  

	14	 Termination for Cause 

 

	 	14.1	 The Company shall be entitled to terminate the Employment effective immediately without notice or payment in
lieu of notice for Cause (as defined in this Section 14) by serving written notice (“Notice of Termination for Cause”). 

  

	 	14.2	 “Cause” shall mean: 

 

	 	14.2.1	 the Executive is convicted of any criminal offense which in the reasonable opinion of the Chairman of GSK plc
or the GSK Board affects the Executive’s position as Chief Scientific Officer and President R&D (other than a motoring offence for which no custodial sentence is given to him); or 

 

	 	14.2.2	 the Executive, in carrying out his duties under the Employment, is found to have engaged in significant
misconduct (e.g., violation of regulation, law, or a significant GSK policy, such as the Code of Conduct) in the sole determination of the Company; or 

  

	 	14.2.3	 the Executive shall become personally bankrupt or insolvent; or 

 

	 	14.2.4	 the Executive shall be or become prohibited by law from being an employee, officer, or director; or

  

	 	14.2.5	 the Executive commits a material breach of any term of this Agreement. 

 

	 	14.3	 Any delay or forbearance by the Company in exercising any right of termination shall not constitute a waiver of
it. 

  

	 	14.4	 In the event that the Employment is terminated for Cause, the Employment shall terminate upon the date on which
the Board serves Notice of Termination for Cause and, except as otherwise required by applicable law, the Executive shall be paid only previously earned compensation , up to the date of termination including reimbursement for expenses previously
incurred and, save for the provisions of this Section 14.4, the Executive will have no claim for further compensation including incentive compensation or damages or any other remedy against the Company or any Group Company.

  

	15	 Termination by Notice Requirements, Additional Detail 

 

	 	15.1	 Subject to Sections 13 and 14 of this Agreement, the Employment under the terms of this Agreement shall
terminate on the occurrence of either: 

  

	 	15.1.1	 The election of the Company, upon not less than 12 months notice in writing by the Company to the Executive in
accordance with Section 3.1(ii); or 

  

	 	15.1.2	 The election of the Executive, upon not less than 12 months notice in writing by the Executive to the Company
in accordance with Section 3.1(iii). 

 Notwithstanding any other provision of this Agreement to the contrary, if,
following delivery of the notice as required under Section 3.1(ii) or 3.1(iii), the Executive abandons his employment with the Company prior to expiration of the 12 month notice period, the Executive shall be entitled to receive only those
payments set forth in Section 15.3 of this Agreement. 

  
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	 	15.2	 In the event the Employment terminates pursuant to Section 15.1.1, the Executive shall be entitled to
receive the Accrued Obligations on or as soon as practicable following the Termination Date coinciding with the expiration of the 12 month notice period. Alternatively, the Company may, in its absolute discretion, lawfully terminate the Employment
immediately upon delivery of the written notice set forth in Section 3.1(ii) and pay the Executive a cash payment equal to 100% of his annual base salary (as in effect immediately prior to the Termination Date), payable in a lump sum as soon as
practicable on or following the Termination Date and any remuneration previously earned or deferred by the Executive (together with any accrued interest) and not yet paid by the Company. 

 

	 	15.3	 In the event the Employment terminates pursuant to Section 15.1.2, or if the Executive abandons the
Employment following delivery of the notice set forth in Section 3.1(ii) or 3.1(iii) but prior to expiration of the 12 month notice period, except as otherwise required by applicable law, the Executive shall be entitled only to payment of all
previously earned or deferred compensation then due and owing under this Agreement, up to the Termination Date, any unpaid bonus pertaining to the previous financial year, and reimbursement for expenses previously incurred and, save for the
provisions of this Section 15.3, the Executive will have no claim for damages or any other remedy against the Company or any Group Company. In the event the Executive abandons the Employment following delivery of the notice set forth in
Section 3.1(ii) or 3.1(iii) but prior to the expiration of the 12 month notice period, the Company may terminate the Employment effectively immediately and bring forward the Termination Date and, in this event, the Company agrees not to pursue
any claim for damages arising out of the Executive’s abandonment of the remaining notice period, save for its rights to enforce any other Section or Appendix of this Agreement including, but not limited to, Sections 10, 11, 12, 16, and 27 and
Appendix 3 and 4, which are unaffected. The amounts described in this Section 15.3 shall be paid as soon as practicable on or following the Termination Date. 

 

	16	 Restrictions during and after Termination of Employment 

 

	 	16.1	 In this Section: 

“Restricted Business” means any existing or prospective lines of business, any division, any business unit, or any product or
service of the Group with which the Executive worked, or which the Executive supported, during the last 12 months of the Employment. 

“Restricted Period” means any period during which the Executive is employed by the Company and the period of 12 months
commencing on the Termination Date. In the event the Employment is terminated by Notice under paragraphs 15.1 and 3.1(ii) or 3.1(iii), the 12 month period is reduced by any time period between the delivery of Notice and the Termination Date itself.

  

	 	16.2	 The Executive will acquire Confidential Information and personal knowledge of and influence over customers,
clients and employees of the Company, GSK plc and its Group Companies during the course of the Employment. The improper disclosure or use of such information or knowledge by the Executive would cause the Group irreparable harm. To protect these
interests, and prevent such harm, the Executive agrees with the Company and GSK plc that the Executive will be bound by the following covenants: 

  

	 	16.2.1	 During the Employment, the Executive will not be employed by, affiliated with (except as the holder, directly
or indirectly, of less than 5 per cent of the shares) work for, or render services similar to those which the Executive is involved during the Employment on behalf of, any firm or business organization that competes or is planning to compete
with the Restricted Business, or render services to, or assist in any way, any competitor of the Group by working on or having any involvement with products or services that are similar to the Restricted Business. 

 

  
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	 	16.2.2	 During the Employment, the Executive will not canvass, solicit or induce any customer, client or vendor of the
Company or any Group Company to become a customer, client or vendor of any other person, firm, or corporation other than the Group with respect to the Restricted Business. After the Executive’s Employment with the Company, the Executive will
not use Confidential Information to canvass, solicit or induce any customer, client or vendor of the Company or any Group Company to become a customer, client or vendor of any other person, firm, or corporation other than the Group with respect to
the Restricted Business. 

  

	 	16.2.3	 During the Restricted Period, the Executive will not interfere or endeavor to interfere with the continuance of
the provision of goods or services to the Company, or any Group Company, by any supplier which was a supplier of goods or services to the Company, or any Group Company during the last 12 months of the Employment. 

 

	 	16.2.4	 During the Restricted Period, the Executive will not solicit or attempt to solicit any officer, director,
senior employee or senior consultant of the Group to leave the Group to join or perform services on behalf of any other person or entity. 

  

	 	16.3	 Each of the obligations imposed on the Executive by this Section 16 extend to the Executive acting not
only on his own account but also on behalf of any other firm, company or other person and shall apply whether the Executive acts directly or indirectly. 

  

	 	16.4	 Following the Termination Date, the Executive will not represent himself as being in any way connected with the
businesses of the Company, GSK plc or of any other Group Company (except to the extent agreed in writing by such a company). 

  

	 	16.5	 Any benefit given or deemed to be given by the Executive to any Group Company under the terms of this
Section 16 is received and held in trust by the Company for the relevant Group Company. The Executive will enter into appropriate restrictive covenants directly with other Group Companies if asked to do so by the Company or GSK plc.

  

	17	 Consideration and Reasonableness of Restrictions 

 

	 	17.1	 The Executive acknowledges that the restrictions contained in Section 16 are supported by consideration in
the form of compensation received by the Executive under this Agreement. 

  

	 	17.2	 Each of the obligations on the Executive contained in Section 16 constitutes a separate and independent
restriction on the Executive notwithstanding that they may be contained in the same Section, paragraph or sentence. 

  

	 	17.3	 Should the restrictions contained in Section 16 be found to be void but would be valid if some part
thereof were deleted or the period or radius of application reduced, then such restriction shall apply with such modification as may be necessary to make it valid and effective. In particular, the Executive agrees that the restrictions are
reasonable and necessary for the protection of the Company and the Group Companies. 

  

	 	17.4	 If the Executive shall, during the Restricted Period, receive from any person, firm or company, an offer to
provide services in any capacity whatsoever, or to enter into employment where acceptance of such offer, or the taking of such employment, might render the Executive in breach of the provisions of this Agreement, the Executive shall promptly advise
the offeror of the existence of the restrictions set forth in Section 16 of this Agreement. 

  

	 	17.5	 The Executive acknowledges that the Company may have no adequate remedy at law and would be irreparably harmed
if the Executive breaches or threatens to breach the provisions of Section 16 above and, therefore, agrees that the Company shall be entitled to injunctive relief to prevent any breach or threatened breach of Section 16 above, and to
specific performance of the terms of each such Section in addition to any other legal or equitable remedy it may have. The Executive further agrees that he shall not, in any equity proceedings involving the Executive relating to the enforcement of
Section 16 above raise the defense that the Company has an adequate remedy at law. Nothing in this Agreement shall be construed as prohibiting the Company from pursuing any other remedies at law or in equity that it may have.

  
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	18	 Severability 

In the event that any provision or portion of this Agreement shall be determined to be invalid or unenforceable for any reason, the remaining
provisions or portions of this Agreement shall be unaffected thereby and shall remain in full force and effect to the fullest extent permitted by law. 
  

	19	 Successors and Assigns 

 

	 	19.1	 This Agreement shall be binding upon and inure to the benefit of the Company or any corporation or other entity
to which the Company may transfer all or substantially all of its assets and business and to which the Company may assign this Agreement, in which case “Company”, as used in this Agreement, shall mean such corporation or other entity. The
foregoing shall not relieve the Company of any of its obligations under Section 15 of this Agreement. The rights of the Executive shall inure to the benefit of his heirs, executors, administrators and other personal representatives.

  

	 	19.2	 The Executive may not assign this Agreement or any part of it, or any rights thereunder or delegate any duties
to be performed by him under it to anyone else. 

  

	20	 Survivorship 

To the extent contemplated by this Agreement, respective rights and obligations of the parties set out in this Agreement shall survive any
termination of this Agreement to the extent necessary to the intended preservation of such rights and obligations. 
  

	21	 Notices 

Any notice (including any notice of termination of the Employment) required or permitted to be given under this Agreement shall be in writing
and shall be deemed to have been given when delivered personally or sent by courier, duly addressed to the party concerned at such address as the party may notify to the other. Any notice delivered personally under this Section 21 shall be
deemed given on the date delivered and any notice sent by courier shall be deemed given on the date delivery is recorded by such courier. 
  

	22	 Entire Agreement 

 

	 	22.1	 This Agreement supersedes any previous written or oral agreement between the parties in relation to the matters
dealt with in it. It contains the whole agreement between the parties relating to the Employment at the date the agreement was entered into (except for those terms implied by law which cannot be excluded by the agreement of the parties). The
Executive acknowledges that he has not been induced to enter into this Agreement by any representation, warranty or undertaking not expressly incorporated into it. 

 

	 	22.2	 Neither party’s rights or powers under this Agreement will be affected if: 

 

	 	22.2.1	 one party delays in enforcing any provision of this Agreement; or 

 

	 	22.2.2	 one party grants time to the other party. 

 

	23	 Amendment or Modification; Waiver 

No provision of this Agreement may be amended or waived unless such amendment or waiver is agreed to in writing, signed by the Executive and by
a duly authorised officer of the Company who shall supply the Executive with evidence of such authority. 
  

  
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	24	 Withholding 

Anything to the contrary notwithstanding, all payments required to be made by the Company under this Agreement to the Executive, or to his
estate or beneficiaries, shall be subject to withholding of such amounts relating to taxes as the Company may be required to withhold pursuant to any applicable statute, law or regulation. 

 

	25	 Indemnification and Insurance 

 

	 	25.1	 The Company agrees that if the Executive is made a party or is threatened to be made a party to any action,
suit, proceeding or governmental or other investigation by reason of the fact of the Employment or that he is or was a director, officer or employee of the Company or is or was serving at the request of the Company as a director, officer, employee
or agent of another Group Company or entity except for any action instigated by the Company or the Executive (a “Proceeding”), he shall be indemnified by the Company to the fullest extent permitted by applicable law against all
expenses, liabilities and losses reasonably incurred or suffered by the Executive in connection with such a Proceeding (including any tax payable by the Executive as a result of payments made by the Company pursuant to this indemnity), including,
without limitation, payment of expenses incurred in defending a Proceeding prior to the final disposition of such Proceeding; PROVIDED, however, that written notice of such Proceeding is given promptly to the Company by the Executive and the Company
is permitted (where appropriate) to participate in and assume the defence of such Proceeding. The provisions of this Section 25 shall survive the termination of the Employment and shall be in addition to any other rights to indemnification to
which the Executive may from time to time be entitled, whether under any applicable insurance policies or otherwise. 

  

	 	25.2	 The Company will provide the Executive with Legal Expenses Insurance and Directors’ and Officers’
Liability Insurance under the Company’s policy current from time to time in force subject to such cover being available at reasonable commercial rates. 

  

	26	 Collective Agreements – Disciplinary Rules and Procedures 

There are no collective agreements which directly affect the terms and conditions set out in this Agreement. 

The Company’s harassment and bullying policies, disciplinary rules and procedures and grievance procedures, as in force from time to time,
shall apply to the Executive. The Company reserves the right to leave out any or all of the stages of those rules and procedures where it considers it appropriate to do so. 
  

	27	 Executive Financial Recoupment Policy 

The Company’s standard policy on financial recoupment shall apply to the Executive. The current policy titled Executive Financial
Recoupment Policy is attached as Appendix 4 and incorporated by reference herein. 
  

	28	 Data Protection 

The Executive consents to the Company or any Group Company holding and processing both electronically and manually the data it collects which
relates to the Executive for the purpose of the administration and management of its employees and its business and for compliance with applicable procedures, laws and regulations. The Executive also consents to the transfer of such personal
information to other offices the Company may have or to a Group Company or to other third parties whether or not outside the United States for administration purposes and other purposes in connection with the Executive’s Employment where it is
necessary or desirable for the Company to do so. 
  

  
 11 

	29	 Section 409A 

 

	 	29.1	 It is the intention of the parties to this Agreement that no payment or entitlement pursuant to this
Agreement will give rise to any adverse tax consequences to the Executive under Section 409A of the Code and Department of Treasury regulations and other interpretive guidance issued thereunder, including that issued after the date hereof. The
Agreement shall be interpreted to that end and, consistent with that objective and notwithstanding any provision herein to the contrary, the Company may take any action it deems necessary or desirable to amend any provision herein to avoid the
application of or excise tax under Section 409A, after giving the Executive reasonable notice and opportunity to comment. Further, no effect shall be given to any provision herein in a manner that reasonably could be expected to give rise to
adverse tax consequences under Section 409A of the Code. 

  

	 	29.2	 Any annual cash bonus that the Executive shall become entitled to receive hereunder for any calendar year shall
be paid by the Company at such time and in such manner that annual bonuses are paid to other senior executives of the Company, but not later than the March 15 immediately following the end of the applicable calendar year; provided it shall not
be a breach of this Agreement if payment is made later in the year to the extent the bonus is not determinable by March 15 and payment is made by payroll no later than December 31 of such year. 

 

	 	29.3	 All payments to be made upon a termination of Employment under the Agreement will only be made upon a
“separation from service” under Section 409A of the Code. In no event may the Executive, directly or indirectly, designate the calendar year of payment. To the maximum extent permitted under Section 409A of the Code and its
corresponding regulations, the amounts payable under the Agreement to be made upon termination of Employment are intended to meet the requirements of the short-term deferral exemption under Section 409A of the Code and the “separation pay
exception” under Treas. Reg. §1.409A-1(b)(9)(iii). For purposes of the application of Treas. Reg. §1.409A-1(b)(4) (or any successor provision), each payment in a series of payments to the Executive will be deemed a separate payment.

  

	 	29.4	 Notwithstanding anything in this Agreement to the contrary, in the event that the Executive is deemed to
be a “specified employee” within the meaning of Section 409A(a)(2)(B)(i) of the Code, any payment under this Agreement that constitutes deferred compensation subject to 409A of the Code and would otherwise commence to be paid as a
result of the Executive’s “separation from service” (as defined in Section 409A of the Code and any Treasury Regulations promulgated thereunder), will not be made to the Executive before the lapse of six months after the date
such payment would have been made but for this Section 29.4. Any payments that are postponed in accordance with this Section 29.4 shall be paid in a lump sum payment within 10 days after the end of the six month period. If the Executive
dies during the postponement period prior to payment of the postponed amount, the amounts withheld on account of Section 409A of the Code shall be paid to the personal representative of the Executive’s estate within 60 days after the date
of Executive’s death. 

  

	30	 Governing Law 

This Agreement shall be deemed a contract made under, and for all purposes shall be construed in accordance with, the laws of the Commonwealth
of Pennsylvania. Each of the parties submits to the exclusive jurisdiction of the Commonwealth of Pennsylvania’s courts as regards any claim or matter under this Agreement. 

  
 12 

	31	 Titles 

Titles to the Sections in this Agreement are intended solely for convenience and no provision of this Agreement is to be construed by reference
to the title of any Section. 
 In witness whereof the parties hereto have executed this Agreement as a deed on the day and year first above
written 
  

			
	 GLAXOSMITHKLINE LLC
	  	
		
	 By: /s/ Dan Troy 
	  	
		
	 Name: Daniel B Troy 
	  	
		
	Title: General Counsel and SVP	  	
		
	Date: December 8, 2017	  	
		
	HAL V. BARRON	  	
		
	 /s/ Hal V. Barron
	  	
		
	Date: 16 December 2017	  	
		
	 Signed Sealed and Delivered by the

said
 HAL V. BARRON
in the presence of:
	  	 }/s/ Carol Cunningham

		
	 Name: Carol Cunningham
  

Address
	  	

  
 13EX-4.5

 Exhibit 4.5 
  

 
 Dated 18 September 2018 

GLAXOSMITHKLINE SERVICES UNLIMITED 

and 
 IAIN MACKAY 

SERVICE AGREEMENT 

 This Agreement is made on 18 September, 2018 between: 

 

	(1)	 GLAXOSMITHKLINE SERVICES UNLIMITED whose registered office is at GSK House, Brentford, Middlesex, TW8
9GS (the “Company”); and 

  

	(2)	 IAIN MACKAY (the “Executive”). 

 

	1	 Interpretation 

 

	 	1.1	 In this Agreement (and any schedules to it) 

“Accrued Obligations” means: 
  

	 	1.1.1	 the Executive’s base salary under this Agreement through to the end of the month in which the
Termination Date occurs at the rate in effect on the Termination Date and the reimbursement (in accordance with Group policy) of any expenses incurred by the Executive prior to the Termination Date; 

 

	 	1.1.2	 any unpaid bonus pertaining to the previous financial year and the product of any target bonus for the
financial year in which the Termination Date occurs and a fraction, the numerator of which is the number of days in the Company’s current financial year up to the Termination Date and the denominator of which is 365; 

 

	 	1.1.3	 any remuneration previously deferred by the Executive (together with any accrued interest) and not yet
paid by the Company including payment for any accrued holiday not taken by the Executive; and 

  

	 	1.1.4	 any other benefits to which the Executive is entitled, as determined in accordance with the applicable
plans and policies of the Company; 

 “Board” means the board of directors of the Company from time to
time or any person or committee nominated by that board as its representative for the purposes of this Agreement; 

“Employment” means the employment governed by this Agreement; 

“Group” means the Company and any other company controlling, controlled by or under the direct or indirect common control of
the Company, including, without limitation, GSK plc and any of its subsidiaries from time to time; 
 “Group Company” means
a member of the Group and “Group Companies” will be interpreted accordingly; 
 “GSK Board” means the board
of directors of GSK plc from time to time or any person or committee nominated by the GSK Board as its representative for the purposes of this Agreement; 

“GSK plc” means GlaxoSmithKline plc; 

“Termination Date” means the date on which the Employment terminates, whether on the expiration of notice to terminate the
Employment pursuant to Section 3 or otherwise pursuant to this Agreement. 
  

	 	1.2	 References to any statutory provisions include any modifications or
re-enactments of those provisions. 

  

	 	1.3	 In this Agreement, terms used in the context of the GlaxoSmithKline 2009 Performance Share Plan shall
have the meaning ascribed to them in such plan. 

  
  

- 1 - 

	2	 Employment 

The Company confirms the employment of the Executive, and the Executive confirms his employment with the Company, on the terms and conditions
set out in this Agreement. 
  

	3	 Termination by Notice 

 

	 	3.1	 The Employment under the terms of this Agreement shall be deemed to have commenced on 14 January,
2019 and the Employment shall continue until: 

  

	 	(i)	 the Employment is otherwise terminated in accordance with this Agreement; or 

 

	 	(ii)	 not less than 12 calendar months’ notice in writing is given by the Company to the Executive; or

  

	 	(iii)	 not less than 12 calendar months’ notice in writing is given by the Executive to the Company.

  

	 	3.2	 The Company may, in its absolute discretion, lawfully terminate the employment of the Executive at any
time by paying to the Executive a sum equal to his basic salary (excluding any other benefits) for the period this Agreement would otherwise continue. For this purpose, basic salary shall be the basic salary in effect at the date of termination of
the employment. 

  

	4	 Duties and Responsibilities 

 

	 	4.1	 The Executive shall be appointed as Chief Financial Officer and shall have such powers and duties as are
from time to time given to him by the Chief Executive Officer consistent with the Employment and this Agreement. In addition, and for no additional consideration, the Executive shall serve as a director on the GSK Board and, if requested by the GSK
Board, shall serve as a director on the Board or any other board of directors of any Group Company. The Executive agrees that for the purposes of the Working Time Regulations 1998 he is a managing executive. 

 

	 	4.2	 During the Employment, the Executive shall devote his full business time and energies to the business
and affairs of the Company and GSK plc, consistent with any other duties and responsibilities he may have to any Group Companies. The Executive’s time shall be allocated among the Group Companies in accordance with the Executive’s
reasonable judgment and dependent upon the level of his responsibilities to any other Group Company, subject to the overall supervision and direction of the Chief Executive Officer. 

 

	 	4.3	 The Executive shall not, without the prior written consent of the GSK Board, accept directorships,
trusteeships and other appointments (other than of Group Companies) or carry on or be engaged, concerned or interested either directly or indirectly in any other business or activity. 

 

	 	4.4	 The location of the Executive’s activities shall be at GSK House, but subject to the overall
supervision and direction of the Chief Executive Officer, and to perform properly his duties, he may be required to undertake reasonable travel elsewhere in the world. The Executive is required to reside at a location convenient to the
Company’s offices at GSK House (or such other location as the GSK Board may determine) during the Employment. 

  
  

- 2 - 

	5	 Salary, etc. 

  

	 	5.1	 In consideration of the services to be rendered by the Executive under this Agreement the Executive
shall be paid a salary at the rate of £850,000 per annum payable in accordance with the Company’s pay practices for its executives from time to time in force (but not less frequently than calendar monthly). The salary will be credited to
the Executive’s bank account notified to the Company for the purpose. Salary shall be reviewed annually in accordance with the Company’s normal administrative practices for its executives and may be increased (but not reduced) by the
Company by such amount (if any) as it shall think fit. 

  

	 	5.2	 The Executive shall be entitled subject to Section 6.4 to participate 

 

	 	(i)	 in all such cash bonus plans and programmes as are made available from time to time to board level executives
of the Company in accordance with the Company’s policy (or GSK plc’s policy, as applicable); and 

  

	 	(ii)	 in respect of the salary provided by Section 5.1, in such incentive programmes as are made available from
time to time to board level executives of the Company and/or GSK plc generally, 

 in each case subject to the terms and
conditions of such bonus plans and programmes from time to time in force. Any grants of share options or awards of performance shares under such plans and programmes shall be granted subject to performance conditions as determined by the GSK Board.
The Executive’s future participation in certain of these plans and programmes may be affected if he does not satisfy the Share Ownership Requirements (as amended from time to time). It is agreed that in the event of the Executive retiring from
the Company, the Executive will retain the relevant number of shares (as set out in the Share Ownership Requirements) until one year after the date on which the Executive retires from the Company in accordance with the terms of any Company policy
(as may be in force from time to time). 
  

	 	5.3	 The Executive’s salary under Section 5.1 of this Agreement shall be inclusive of any fees or
other remuneration to which the Executive may be entitled or receives as a Director, alternate Director, specialist adviser, consultant or by virtue of any other office or appointment in any Group Company. The Executive shall account to the Company
for all such fees or other remuneration by paying over or procuring to be paid over the same to the Company. 

  

	 	5.4	 GSK shall not be liable for any costs or expenses, including any costs or expenses pertaining to travel
undertaken by the Executive, incurred as a result of any activity or participation in any role or capacity external to and unrelated to GSK or any Group Company. It is agreed that the Executive will promptly reimburse GSK against any such costs that
may be incurred by GSK. Further, the Executive authorises the Company at any time to deduct from his salary, or any other monies payable to him by the Company, all sums which he owes the Company. If this is insufficient, the Company will require
repayment of the balance. 

  

	6	 Expenses and other Benefits 

 

	 	6.1	 The Company shall promptly reimburse to the Executive all reasonable travel and other out of pocket
expenses properly incurred in the performance of his duties under the Employment. The Executive will submit claims for expenses reimbursement to the Company regularly with appropriate supporting documentation. 

  
  

- 3 - 

	 	6.2	 The Executive is eligible to participate in the GlaxoSmithKline Cash Allowance and Car Ownership Scheme
subject to the rules of the scheme as amended from time to time. Full details of the Scheme are available on the TotalReward section on myGSK. 

  

	 	6.3	 The Company at its expense shall provide the Executive with other benefits provided to board level
executives of the Company, and the Executive shall be entitled to participate in all benefit plans, practices and policies as are made available by the Company from time to time to its board level executives subject to their terms and conditions
from time to time in force. Details of the relevant plans and programmes are set out in the TotalReward section on my GSK. 

  

	 	6.4	 The Company (and GSK plc, as applicable) reserves the absolute right and discretion to amend, modify or
terminate all such benefits, plans and programmes as are referred to in Sections 5.2, 6.2, 6.3 and 8 at any time and for any reason. 

  

	7	 Holidays 

In addition to all statutory and Bank Holidays, the Executive shall be entitled to 28 days’ holiday in each year at full pay, in
accordance with Company policy from time to time in force, which shall accrue rateably during the calendar year. Up to four days of such holiday shall be taken at times to be designated by the Company and the remainder shall be taken at such times
as the business of the Company may permit. On termination of the Employment the Executive will be entitled to be paid for any accrued holiday not taken and will reimburse the Company for any holiday taken but not accrued. 

Holiday which is not taken in the year in which it is accrued may be carried forward, in accordance with the Company’s rules on the
banking of holidays outlined in its Holiday Policy, as amended from time to time. Any holiday which is not banked in accordance with these rules will be lost. 
  

	8	 Pension and Life Insurance 

The Executive is entitled to be a member of the GSK Pension Plan Senior Executive section (“the Pension Plan”), subject to the
conditions of the trust deed and rules governing the Pension Plan from time to time. If the Executive has reached or reaches any limit set by the Government relating to pension allowances, the Executive can opt out of the Pension Plan and the
Company may pay him a cash supplement in lieu of any employer pension contributions. The Pension Plan is subject to amendment or withdrawal at the Company’s discretion. Any contributions payable by the Executive to the pension plan
will be deducted from salary via salary sacrifice. The Company shall provide the Executive with the benefit of life cover which would provide a lump sum equivalent to four times the level of his base salary in the event of death in service. 

 

	9	 Sickness 

  

	 	9.1	 The Executive shall comply with the Company’s sick pay rules from time to time in force.

  

	 	9.2	 Without prejudice to the Company’s right to terminate the Employment in accordance with Sections 3,
13, 14 and 15, if the Executive is absent from the Employment as a result of sickness or injury he shall be paid his full salary for the first 26 weeks’ absence (whether or not consecutive) and half of his salary for the second 26 weeks
(whether or not consecutive) in aggregate in any period of 24 calendar months. The amount of any benefit which the Executive is entitled to claim during that period of absence under any Social Security or National Insurance Scheme and/or any Scheme
of which the Executive 

  
  

- 4 - 

	 	
is a non-contributory member by virtue of the Employment, will be deducted from any salary paid to him. The Company will pay the Executive statutory sick
pay under the Social Security Contributions and Benefits Act 1992 (as amended) and any salary paid to him will be deemed to include statutory sick pay. The Company reserves the right to offset the amount of these benefits against salary paid to the
Executive even if the Executive has not recovered them. 

  

	 	9.3	 The Company may request the Executive to have a medical examination every year (or at such shorter
intervals as they may agree between them), by a doctor approved by the Company. The costs of such examinations shall be borne by the Company. 

  

	10	 Inventions and Copyright 

The Company’s standard policy on inventions and copyright from time to time in force shall apply to the Executive. 

 

	11	 Confidentiality; Company Securities 

 

	 	11.1	 Without prejudice to any other duty owed to the Company or to any Group Company, the Executive shall
not, except in the proper performance of his duties or as authorised by the Board, during or after the Employment, use or disclose to any person any Confidential Information obtained by him during the Employment. 

 

	 	11.2	 In the course of the Employment, the Executive is likely to obtain trade secrets and confidential
information belonging to or relating to Group Companies and other persons. He will treat such information as if it falls within the terms of Section 11.1 and Section 11.1 will apply with any necessary amendments to such information. If
requested to do so by the Company, the Executive will enter into an agreement with other Group Companies and any other persons in the same terms as Section 11.1 with any amendments necessary to give effect to this provision.

  

	 	11.3	 For the purposes of this Agreement, the term “Confidential Information” shall include,
but not be limited to confidential commercial, financial and strategic data pertaining to the Group and any other confidential information relating to the business or affairs of the Group including, without limitation, any invention, trade secret,
manufacturing process or patent information. The term “Confidential Information” shall not include any information: 

  

	 	11.3.1	 which is or becomes generally available to the public; or 

 

	 	11.3.2	 which is acquired by the Executive apart from his association with the Group 

other than, in each case, as a result of disclosure by the Executive or by any person to whom he has supplied information or by any person in
breach of a duty of confidentiality. 
 In addition, the term “Confidential Information” shall not include any information which
the Executive is required to disclose by applicable law or regulation or by order of a court or governmental body of competent jurisdiction. This does not affect any rights the Executive has under Part IVA of the Employment Rights Act 1996. 

 

	 	11.4	 During the Employment, the Executive shall be bound, in respect of transactions in securities issued by
any Group Company, by the Company’s and GSK plc’s policies from time to time in effect on employee securities dealing. In particular, the Executive shall advise the Chief Executive Officer, Chairman or Company Secretary of GSK plc before
he or any member of his immediate family seeks to trade in such securities and shall be bound by any directions given by the said Chief Executive Officer, Chairman or Company Secretary. 

  
  

- 5 - 

	12	 General Termination Provisions 

 

	 	12.1	 On the termination of the Employment for whatever reason, or at any other time when requested to do so
by the Company, the Executive, upon receipt of written request from the Company, shall promptly 

  

	 	(i)	 deliver up to the Company any property belonging to the Company or any other Group Company which may be in his
possession or under his control including Confidential Information, lists of customers, correspondence, documents and other property. The Executive will not retain any copies of any materials or other information. The Company shall promptly return
to the Executive and permit him to remove from the premises of the Company and any other Group Company, any property, personal records, files, etc. belonging to the Executive; and 

 

	 	(ii)	 resign on request by the Company or the GSK Board (if he has not already done so) from all offices held by him
in the Company and any other Group Company (except for any he is entitled to retain under any separate agreement with any Group Company), failing which the Executive irrevocably authorises the Company or GSK plc to appoint an officer of the Company
or GSK plc to execute all documents on his behalf and do all things necessary to effect such resignations; PROVIDED, however, that any such resignations pursuant to this Section 12.1(ii) shall be without prejudice to the Executive’s rights
under this Agreement. 

  

	 	12.2	 Any termination of the Employment shall be without prejudice to the Executive’s and the
Company’s continuing obligations under this Agreement. 

  

	 	12.3	 Upon the termination of the Executive’s employment for whatever reason, the Executive shall
immediately repay all outstanding debts or loans due to the Company or any Group Company and the Company is hereby authorised to deduct from any payment of wages any sum in repayment of all or any part of such debts or loans. 

 

	 	12.4	 The terms of the GSK Redundancy Policy as in force from time to time, shall not apply to the Executive
who shall only be entitled to statutory redundancy pay in addition to any other entitlement under this Agreement if his Employment is terminated by reason of redundancy. 

 

	13	 Termination due to Death or Disability 

 

	 	13.1	 In the event of the Executive’s death, the Employment will terminate automatically on the date of
his death, which shall be the Termination Date for the purposes of this Agreement. His duly qualified executor shall be entitled to receive the Accrued Obligations. 

 

	 	13.2	 The Company may elect to terminate the Employment immediately without notice or payment in lieu of
notice by serving written notice (“Termination Notice for Disability”), if an independent physician selected by the Company has certified in writing that, by reason of a physical or mental illness or other condition of the
Executive, the Executive is unlikely to be able to resume performance of duties under the Employment for the foreseeable future. The Employment will terminate on the Termination Date specified in the Termination Notice for Disability. Provided that
the Company shall not be entitled to terminate the employment by reason of physical or mental illness or other condition if this would lead to the Executive becoming dis-entitled to benefits under the
Company’s or GSK plc’s permanent health insurance plan. 

  
  

- 6 - 

	 	13.3	 In the event the Company delivers a Termination Notice for Disability, the Executive shall immediately
be relieved from all offices, appointments and responsibilities that he may then hold under the Employment and be relieved of any duty to work for or serve the Company or any Group Company. The Executive shall be entitled only to the Accrued
Obligations, together with such rights as are provided for in the applicable benefits plan(s) in which the Executive participates. 

  

	14	 Termination for Cause 

 

	 	14.1	 The Company shall be entitled to terminate the Employment immediately without notice or payment in lieu
of notice for Cause (as defined in this Section 14) by serving written notice (“Notice of Termination for Cause”). 

  

	 	14.2	 “Cause” shall mean: 

 

	 	14.2.1	 the Executive is convicted of any criminal offence which in the reasonable opinion of the Chairman of
GSK plc or the GSK Board affects the Executive’s position as Chief Financial Officer (other than a motoring offence for which no custodial sentence is given to him); or 

 

	 	14.2.2	 the Executive, in carrying out his duties under the Employment, is found guilty of gross neglect, gross
misconduct, or significant misconduct which would include but not be limited to violation of a relevant and material regulation or law, or of a significant GSK policy or the GSK Code of Conduct; or 

 

	 	14.2.3	 the Executive shall become bankrupt or have an order under Section 252 of the Insolvency Act 1986
made in respect of him or if an interim receiver of his property is appointed under Section 286 of the Act; or 

  

	 	14.2.4	 the Executive shall be or become prohibited by law from being a director; or 

 

	 	14.2.5	 the Executive commits a serious breach of any material term of this Agreement. 

 

	 	14.3	 Any delay or forbearance by the Company in exercising any right of termination shall not constitute a
waiver of it. 

  

	 	14.4	 In the event that the Employment is terminated for Cause, the Employment shall terminate upon the date
on which the Board serves Notice of Termination for Cause and the Executive shall be entitled only to payment of all previously accrued and unpaid salary then due and owing under this Agreement, up to the date of termination including reimbursement
for expenses previously incurred and, save for the provisions of this Section 14.4, the Executive will have no claim for damages or any other remedy against the Company or any Group Company. 

 

	15	 Termination by Notice 

 

	 	15.1	 If either notice to terminate the Employment is given by the Executive according to
Section 3.1(iii) above, or if the Executive resigns without giving due notice and the Company does not accept his resignation or the Company has given notice in accordance with Section 3.1(ii) above then the Company may require the
Executive to comply with any and all of the provisions in this Section 15.1 for a maximum period of 12 months (the “Garden Leave Period”). 

  
  

- 7 - 

	 	15.1.1	 The Company may require that the Executive does not: 

 

	 	(i)	 enter or attend the premises of the Company, or any Group Company; or 

 

	 	(ii)	 contact or have any communication with any customer or client of the Company, or any Group Company in relation
to the business of the Company, or any Group Company; or 

  

	 	(iii)	 contact or have any communication with any employee, officer, director, agent or consultant of the Company, or
any Group Company in relation to the business of the Company, or any Group Company; or 

  

	 	(iv)	 become employed or engaged by any company, partnership or other entity whether as an employee, director,
partner or consultant or carry on any business either on his own account or for any other person whether directly or indirectly (except as the holder, directly or indirectly, of less than 5 per cent of the shares or save for those activities
permitted in accordance with Section 4.3); 

  

	 	(v)	 remain or become involved in any aspect of the business of the Company, or any Group Company except as required
by such companies. 

  

	 	15.1.2	 The Company may require the Executive: 

 

	 	(i)	 to comply with the provisions of Section 12; and 

 

	 	(ii)	 to immediately resign from any directorship which he holds in the Company, and any Group Company or any other
company where such directorship is held as a consequence or requirement of the Employment, unless he is required to perform duties to which any such directorship relates in which case he may retain such directorships while those duties are ongoing.
The Executive hereby irrevocably appoints the Company to appoint an officer of GSK plc as his attorney to execute any instrument and do anything in his name and on his behalf to effect his resignation if he fails to do so in accordance with this
Section 15.1.2(ii). 

  

	 	15.1.3	 During any Garden Leave Period the Company may appoint another individual to carry out the duties of the
Executive and the Executive shall: 

  

	 	(i)	 continue to be bound by the provisions of this Agreement and conduct himself with good faith towards the
Company and not do anything that is harmful to the Company or any Group Company; 

  

	 	(ii)	 remain available to perform any reasonable duty requested by the Company or any Group Company and to co-operate generally with the Company or any Group Company to ensure a smooth handover of his duties (provided that if the Executive should fail to make himself available for such work having been requested by the
Company or any Group Company to attend he shall, notwithstanding any other provision of this Agreement forfeit his right to salary and contractual benefits in respect of such period of non-availability).

  

	 	15.1.4	 During the Garden Leave Period, the Executive will be entitled to receive his salary and benefits in
accordance with the terms of this Agreement including any bonus payable in accordance with Section 5.2 but excluding any share entitlements under Section 5.2 above. 

  
  

- 8 - 

	 	15.1.5	 Where the Company gives notice to terminate the Employment in accordance with Section 3.2 (except
where termination is effected pursuant to the terms of Section 14) above then notwithstanding the continuation of the Employment during any period after notice has been given, including, any Garden Leave Period, within 30 days of the date such
notice was given to the Executive, the Company shall pay to the Executive as a lump sum his full salary in respect of the entire period of notice (subject to deduction of tax and any other deductions required to be made) (the “Lump
Sum”). For this purpose, full salary shall be the basic salary in effect at the date such notice is given to the Executive. For the avoidance of doubt, the payment by the Company to the Executive of the Lump Sum will extinguish any and all
liability imposed on the Company under this Agreement to make any further payment to the Executive in respect of salary under this Agreement during any period after notice has been given, including, any Garden Leave Period. 

 

	 	15.1.6	 After the payment of a Lump Sum pursuant to Section 15.1.5, at the end of or at any time during the
Garden Leave Period the Company may at its sole and absolute discretion terminate the Employment by further written notice to the Executive without any further payment. In any event at the end of the 12 month Garden Leave Period the Employment will
also terminate automatically and the Company shall be under no obligation to make any further payment to the Executive, save for in respect of any Accrued Obligations that may exist. 

 

	 	15.1.7	 However, in the event that the Executive obtains an offer of future alternative employment with another
employer, or otherwise wishes to take up alternative business activities, and he can satisfy the GSK Board that such employment/activities are not in breach of Section 16, the Company shall waive the balance of any unexpired notice period or
the Garden Leave Period so as to enable the Executive to take up such alternative employment/activities; whereupon, subject to Section 12.3 above, the Company’s obligations to the Executive under this Section 15.1 shall cease with
effect from the agreed revised Termination Date. 

  

	 	15.1.8	 The Company and the Executive agree that if the Company shall fully perform, when due, all its
obligations under this Section 15, such performance shall be in full and final settlement of all and any claims or rights of action which the Executive might have against the Company, or any Group Company arising out of this Agreement or its
termination or otherwise howsoever relating to the Employment. 

  

	16	 Restrictions during and after Termination of Employment 

 

	 	16.1	 In this Section: 

“Restricted Business” means the businesses of the Company or any Group Company at the Termination Date (or if earlier the
start of any Garden Leave Period ending on the Termination Date) with which the Executive was involved to a material extent during the last 12 months of the Employment; and, 

  
  

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 “Restricted Period” means any period during which the Executive is employed
by the Company (including for the avoidance of doubt, any Garden Leave Period) and the period of 12 months, less any Garden Leave Period imposed by the Company under Section 15 and less any period of notice worked by the Executive during the
notice period set out in Section 3, commencing on the Termination Date. 
  

	 	16.2	 The Executive is likely to obtain trade secrets and Confidential Information and personal knowledge of
and influence over customers, clients and employees of the Company, GSK plc and its Group Companies during the course of the Employment. To protect these interests, the Executive agrees with the Company and GSK plc that the Executive will be bound
by the following covenants: 

  

	 	16.2.1	 During the Restricted Period he will not be employed or engaged in (except as the holder, directly or
indirectly, of less than 5 per cent of the shares) any business which is or is about to be in competition with the Restricted Business. 

  

	 	16.2.2	 During the Restricted Period the Executive will not canvass or solicit in competition with the Company,
or any Group Company, the custom of any person who was during the last 12 months of the Employment a customer, or client of, or in the habit of dealing with, the Company, or (as the case may be) any Group Company and in respect of which the
Executive had access to Confidential Information or with whose custom or business the Executive is or was personally concerned, during that 12 month period with a view to providing goods or services to that person in competition with any Restricted
Business. 

  

	 	16.2.3	 During the Restricted Period the Executive will not, in the course of any business concern which is in
competition with the Restricted Business provide goods or services to or otherwise have any dealings with any person who was during the last 12 months of the Employment a customer, or client of, or in the habit of dealing with the Company, or any
Group Company, and in respect of which the Executive had access to Confidential Information or with whose custom or business the Executive is or was personally concerned during that 12 month period. 

 

	 	16.2.4	 During the Restricted Period the Executive will not, interfere or endeavour to interfere with the
continuance of the provision of goods or services to the Company, or any Group Company, by any supplier which was a supplier of goods or services to the Company, or any Group Company during the last 12 months of the Employment and with whom the
Executive dealt to a material extent during that period 

  

	 	16.2.5	 During the Restricted Period he will not entice or try to entice away from the Company or any Group
Company any person who is still employed by the Company or a Group Company during the Restricted Period and is a senior employee, director or full time senior consultant of such a company and with whom he worked closely in the last six months of the
Employment. 

  

	 	16.3	 Each of the obligations imposed on the Executive by this Section 16 extend to him acting not only
on his own account but also on behalf of any other firm, company or other person and shall apply whether he acts directly or indirectly. 

  
  

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	 	16.4	 Following the Termination Date, the Executive will not represent himself as being in any way connected
with the businesses of the Company, GSK plc or of any other Group Company (except to the extent agreed in writing by such a company). 

  

	 	16.5	 Any benefit given or deemed to be given by the Executive to any Group Company under the terms of
Section 16 is received and held on trust by the Company for the relevant Group Company. The Executive will enter into appropriate restrictive covenants directly with other Group Companies if asked to do so by the Company or GSK plc.

  

	17	 Reasonableness of Restrictions 

 

	 	17.1	 Each of the obligations on the Executive contained in Section 16 constitutes a separate and
independent restriction on the Executive notwithstanding that they may be contained in the same Section, paragraph or sentence. 

  

	 	17.2	 Should the restrictions contained in Section 16 be found to be void but would be valid if some part
thereof were deleted or the period or radius of application reduced, then such restriction shall apply with such modification as may be necessary to make it valid and effective. In particular, the Executive agrees that the restrictions are
reasonable and necessary for the protection of the Company and the Group Companies. 

  

	 	17.3	 If the Executive shall, during the Restricted Period, receive from any person, firm or company, an offer
to provide services in any capacity whatsoever, or to enter into employment where acceptance of such offer, or the taking of such employment, might render him in breach of the provisions of this Agreement, he shall promptly advise the offeror of the
existence of the restrictions set forth in Section 16 of this Agreement. 

  

	 	17.4	 The Executive acknowledges that the Company may have no adequate remedy at law and would be irreparably
harmed if the Executive breaches or threatens to breach the provisions of Section 16 above and, therefore, agrees that the Company shall be entitled to injunctive relief to prevent any breach or threatened breach of Section 16 above, and
to specific performance of the terms of each such Section in addition to any other legal or equitable remedy it may have. The Executive further agrees that he shall not, in any equity proceedings involving him relating to the enforcement of
Section 16 above raise the defence that the Company has an adequate remedy at law. Nothing in this Agreement shall be construed as prohibiting the Company from pursuing any other remedies at law or in equity that it may have.

  

	18	 Severability 

In the event that any provision or portion of this Agreement shall be determined to be invalid or unenforceable for any reason, the remaining
provisions or portions of this Agreement shall be unaffected thereby and shall remain in full force and effect to the fullest extent permitted by law. 
  

	19	 Successors and Assigns 

 

	 	19.1	 This Agreement shall be binding upon and inure to the benefit of the Company or any corporation or other
entity to which the Company may transfer all or substantially all of its assets and business and to which the Company may assign this Agreement, in which case “Company”, as used in this Agreement, shall mean such corporation or
other entity. The foregoing shall not relieve the Company of any of its obligations under Section 15 of this Agreement. The rights of the Executive shall inure to the benefit of his heirs, executors, administrators and other personal
representatives. 

  
  

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	 	19.2	 The Executive may not assign this Agreement or any part of it, or any rights thereunder or delegate any
duties to be performed by him under it to anyone else. 

  

	20	 Survivorship 

To the extent contemplated by this Agreement, respective rights and obligations of the parties set out in this Agreement shall survive any
termination of this Agreement to the extent necessary to the intended preservation of such rights and obligations. 
  

	21	 Notices 

Any notice (including any Termination Notice) required or permitted to be given under this Agreement shall be in writing and shall be deemed to
have been given when delivered personally or sent by courier, duly addressed to the party concerned at such address as the party may notify to the other. Any notice delivered personally under this Section 21 shall be deemed given on the date
delivered and any notice sent by courier shall be deemed given on the date delivery is recorded by such courier. 
  

	22	 Entire Agreement 

 

	 	22.1	 This Agreement supersedes any previous written or oral agreement between the parties in relation to the
matters dealt with within it. It contains the whole agreement between the parties relating to the Employment at the date the Agreement was entered into (except for those terms implied by law which cannot be excluded by the agreement of the parties).
The Executive acknowledges that he has not been induced to enter into this Agreement by any representation, warranty or undertaking not expressly incorporated into it. 

 

	 	22.2	 Neither party’s rights or powers under this Agreement will be affected if: 

 

	 	22.2.1	 one party delays in enforcing any provision of this Agreement; or 

 

	 	22.2.2	 one party grants time to the other party. 

 

	23	 Amendment or Modification; Waiver 

No provision of this Agreement may be amended or waived unless such amendment or waiver is agreed to in writing, signed by the Executive and by
a duly authorised officer of the Company who shall supply the Executive with evidence of such authority. 
  

	24	 Withholding 

Anything to the contrary notwithstanding, all payments required to be made by the Company under this Agreement to the Executive, or to his
estate or beneficiaries, shall be subject to withholding of such amounts relating to taxes as the Company may be required to withhold pursuant to any applicable statute, law or regulation. 

 

	25	 Indemnification and Insurance 

 

	 	25.1	 The Company agrees that if the Executive is made a party or is threatened to be made a party to any
action, suit, proceeding, prosecution or governmental, regulatory or other investigation by reason of the fact of the Employment or that he is or was a director, officer or employee of the Company or is or was serving at the request of the Company
as a director, officer, employee or agent of another Group Company or entity except for any action instigated by the Company or the Executive (a “Proceeding”), he shall be indemnified by the Company to the fullest extent permitted
by applicable law against all 

  
  

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expenses, liabilities, fees, costs, damages and losses reasonably incurred or suffered by the Executive in connection with such a Proceeding (including any tax payable by the Executive as a
result of payments made by the Company pursuant to this indemnity), including, without limitation, payment of expenses incurred in defending a Proceeding prior to the final disposition of such Proceeding; PROVIDED, however, that written notice of
such Proceeding is given promptly to the Company by the Executive and the Company is permitted (where appropriate) to participate in and assume the defence of such Proceeding. The provisions of this Section 25 shall survive the termination of
the Employment and shall be in addition to any other rights to indemnification to which the Executive may from time to time be entitled, whether under any applicable insurance policies or otherwise. 

 

	 	25.2	 The Company will provide the Executive with Legal Expenses Insurance and Directors’ and
Officers’ Liability Insurance under the Company’s policy current from time to time in force to cover the period during which he acts as a director, officer or employee or agent of any Group Company or entity under this Agreement whether or
not he remains a director, officer, employee or agent of any Group Company or entity at the time any claim under the policy is made. 

  

	26	 Collective Agreements – Disciplinary Rules and Procedures 

There are no collective agreements which directly affect the terms and conditions set out in this Agreement. 

The Company’s harassment and bullying policies, disciplinary rules and procedures and grievance procedures, as in force from time to time,
shall apply to the Executive. The Company reserves the right to leave out any or all of the stages of those rules and procedures where it considers it appropriate to do so. 
  

	27	 Governing Law 

This Agreement shall be deemed a contract made under, and for all purposes shall be construed in accordance with, the laws of England. Each of
the parties submits to the exclusive jurisdiction of the English courts as regards any claim or matter under this Agreement. 
  

	28	 Titles 

Titles to the Sections in this Agreement are intended solely for convenience and no provision of this Agreement is to be construed by reference
to the title of any Section. 

  
  

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 In witness whereof the parties hereto have executed this Agreement as a deed on the
day and year first above written 
  

			
	THE COMMON SEAL of GLAXOSMITHKLINE SERVICES UNLIMITED was hereunto affixed in the presence of:	  	}/s/ Paul Williamson
		
	 Director
 P Williamson

Authorised Signatory
 For and on behalf of

Edinburgh Pharmaceuticals Industries Limited
 The Corporate
Director
	  	
		
	 Secretary
 /s/ Sonja Reynolds Arseniç

S Reynolds Arseniç
 Authorised Signatory

For and on behalf of
 Glaxo Group Limited

Corporate Director
	  	
		
	 Signed Sealed and Delivered by the

said IAIN MACKAY in the presence of:
	  	 }/s/ Iain Mackay

		
	 Name: Robert Nicol
  

Address
	  	 }/s/ Robert Nicol 

	Occupation	  	

  
  

- 14 -

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