Document:

exv10w8

 

Exhibit
10.8

ALEXZA PHARMACEUTICALS, INC.

2005 EMPLOYEE STOCK PURCHASE PLAN

Adopted by the Board of Directors on December 7, 2005

Approved by the Stockholders on                     , 2005

     1. Purpose.

          (a) The purpose of this Plan is to provide a means by which Employees of the Company and
certain designated Subsidiaries may be given an opportunity to purchase stock of the Company.

          (b) The Company, by means of the Plan, seeks to retain the services of its Employees, to
secure and retain the services of new Employees, and to provide incentives for such persons to
exert maximum efforts for the success of the Company.

          (c) The Company intends that the Purchase Rights granted under the Plan be considered options
issued under an Employee Stock Purchase Plan.

     2. Definitions.

     As used in the Plan and any Offering, unless otherwise specified, the following terms have the
meanings set forth below:

     (a) “Affiliate” means (i) any corporation (other than the Company) in an unbroken chain of
corporations ending with the Company, provided each corporation in the unbroken chain (other than
the Company) owns, at the time of the determination, stock possessing fifty percent (50%) or more
of the total combined voting power of all classes of stock in one of the other corporations in such
chain, and (ii) any corporation (other than the Company) in an unbroken chain of corporations
beginning with the Company, provided each corporation (other than the last corporation) in the
unbroken chain owns, at the time of the determination, stock possessing fifty percent (50%) or more
of the total combined voting power of all classes of stock in one of the other corporations in such
chain. The Board shall have the authority to determine (i) the time or times at which the
ownership tests are applied, and (ii) whether “Affiliate” includes entities other than corporations
within the foregoing definition.

     (b) “Board” means the Board of Directors of the Company.

     (c) “Code” means the Internal Revenue Code of 1986, as amended.

     (d) “Committee” means a committee of one (1) or more members of the Board to whom authority
has been delegated by the Board in accordance with Section 3(c).

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     (e) “Common Stock” means the common stock of the Company.

     (f) “Company” means Alexza Pharmaceuticals, Inc., a Delaware corporation.

     (g) “Contributions” means the payroll deductions, and other additional payments specifically
provided for in the Offering, that a Participant contributes to fund the exercise of a Purchase
Right. A Participant may make additional payments into his or her account, if specifically provided
for in the Offering, and then only if the Participant has not already had the maximum permitted
amount withheld through payroll deductions during the Offering.

     (h) “Corporate Transaction” means the occurrence, in a single transaction or in a series of
related transactions, of any one or more of the following events:

     (1) a dissolution or liquidation of the Company;

     (2) a lease, sale, or other disposition of all or substantially all of the assets of the
Company;

     (3) the consummation of a merger, consolidation or similar transaction following which the
Company is not the surviving corporation; or

     (4) the consummation of a merger, consolidation or similar transaction following which the
Company is the surviving corporation but the shares of Common Stock outstanding immediately
preceding the merger, consolidation or similar transaction are converted or exchanged by virtue of
the merger, consolidation or similar transaction into other property, whether in the form of
securities, cash or otherwise.

     (5) the acquisition by any person, entity or group within the meaning of Section 13(d) or
14(d) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or any comparable
successor provisions (excluding any employee benefit plan, or related trust, sponsored or
maintained by the Company or any Subsidiary) of the beneficial ownership (within the meaning of
Rule 13d-3 promulgated under the Exchange Act, or comparable successor rule) of securities of the
Company representing at least fifty percent (50%) of the combined voting power entitled to vote in
the election of directors; or

     (6) the individuals who, as of the date of the adoption of this Plan, are members of the Board
(the “Incumbent Board”) cease for any reason to constitute at least fifty percent (50%) of the
Board, provided that if the election, or nomination for election by the Company’s stockholders, of
a new director was approved by a vote of at least fifty percent (50%) of the members of the Board
then comprising the Incumbent Board, such new director shall upon his or her election be considered
a member of the Incumbent Board.

     (i) “Director” means a member of the Board.

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     (j) “Earnings” of an Employee with respect to any Offering has the meaning defined in such
Offering.

     (k) “Eligible Employee” means an Employee who meets the requirements set forth in the Offering
for eligibility to participate in the Offering, provided that such Employee also meets the
requirements for eligibility to participate set forth in the Plan.

     (l) “Employee” means any person, including Officers and Directors, who is employed for
purposes of Section 423(b)(4) of the Code by the Company or a Subsidiary. Neither service as a
Director nor payment of a director’s fee shall be sufficient to make an individual an Employee of
the Company or a Subsidiary.

     (m) “Employee Stock Purchase Plan” means a plan that grants Purchase Rights intended to be
options issued under an “employee stock purchase plan,” as that term is defined in Section 423(b)
of the Code.

     (n) “Exchange Act” means the Securities Exchange Act of 1934, as amended.

     (o) “Fair Market Value” means the value of a security, as determined in good faith by the
Board. If the security is listed on any established stock exchange or traded on the Nasdaq
National Market or the Nasdaq SmallCap Market, the Fair Market Value of the security, unless
otherwise determined by the Board, shall be the closing sales price (rounded up where necessary to
the nearest whole cent) for such security (or the closing bid, if no sales were reported) as quoted
on such exchange or market (or the exchange or market with the greatest volume of trading in the
relevant security of the Company) on the relevant determination date (or if the relevant
determination date does not fall on a Trading Day, the Trading Day prior to the relevant
determination date), as reported in The Wall Street Journal or such other source as the Board deems
reliable.

     (p) “Initial Offering” means the first Offering under this Plan.

     (q) “Non-Employee Director” means a Director who either (i) is not a current employee or
officer of the Company or an Affiliate, does not receive compensation, either directly or
indirectly, from the Company or an Affiliate for services rendered as a consultant or in any
capacity other than as a Director (except for an amount as to which disclosure would not be
required under Item 404(a) of Regulation S-K promulgated pursuant to the Securities Act
(“Regulation S-K”)), does not possess an interest in any other transaction for which disclosure
would be required under Item 404(a) of Regulation S-K, and is not engaged in a business
relationship for which disclosure would be required pursuant to Item 404(b) of Regulation S-K; or
(ii) is otherwise considered a “non-employee director” for purposes of Rule 16b-3.

     (r) “Offering” means the grant of Purchase Rights to purchase shares of Common Stock under the
Plan to Eligible Employees.

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     (s) “Offering Date” means a date selected by the Board for an Offering to commence.

     (t) “Officer” means a person who is an officer of the Company within the meaning of Section 16
of the Exchange Act and the rules and regulations promulgated thereunder

     (u) “Outside Director” means a Director who either (i) is not a current employee of the
Company or an “affiliated corporation” (within the meaning of Treasury Regulations promulgated
under Section 162(m) of the Code), is not a former employee of the Company or an “affiliated
corporation” who receives compensation for prior services (other than benefits under a
tax-qualified retirement plan) during the taxable year, has not been an officer of the Company or
an “affiliated corporation,” and does not receive remuneration from the Company or an “affiliated
corporation,” either directly or indirectly, in any capacity other than as a Director, or (ii) is
otherwise considered an “outside director” for purposes of Section 162(m) of the Code.

     (v) “Participant” means an Eligible Employee who holds an outstanding Purchase Right granted
pursuant to the Plan.

     (w) “Plan” means this Alexza Pharmaceuticals, Inc. 2005 Employee Stock Purchase Plan.

     (x) “Purchase Date” means one or more dates during an Offering established by the Board on
which Purchase Rights shall be exercised and as of which purchases of shares of Common Stock shall
be carried out in accordance with such Offering.

     (y) “Purchase Period” means a period of time specified within an Offering beginning on the
Offering Date or on the next day following a Purchase Date within an Offering and ending on a
Purchase Date. An Offering may consist of one or more Purchase Periods.

     (z) “Purchase Right” means an option to purchase shares of Common Stock granted pursuant to
the Plan.

     (aa) “Related Corporation” means any parent corporation or subsidiary corporation, whether now
or hereafter existing, as those terms are defined in Sections 424(e) and (f), respectively, of the
Code.

     (bb) “Securities Act” means the Securities Act of 1933, as amended.

     (cc) “Subsidiary” means any subsidiary corporation of the Company, whether now or hereafter
existing, as such term is defined in Section 424(f) of the Code.

     (dd) “Trading Day” means any day the exchange(s) or market(s) on which shares of Common Stock
are listed, whether it be any established stock exchange, the Nasdaq National Market, the Nasdaq
SmallCap Market or otherwise, is open for trading.

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     3. Administration.

          (a) The Plan shall be administered by the Board unless and until the Board delegates
administration to a Committee, as provided in subparagraph 3(c). Whether or not the Board has
delegated administration, the Board shall have the final power to determine all questions of policy
and expediency that may arise in the administration of the Plan.

          (b) The Board shall have the power, subject to, and within the limitations of, the express
provisions of the Plan:

               (i) To determine when and how Purchase Rights shall be granted and the provisions of each
offering of such Purchase Rights (which need not be identical).

               (ii) To designate from time to time which Subsidiaries shall be eligible to participate in the
Plan.

               (iii) To construe and interpret the Plan and Purchase Rights granted under it, and to
establish, amend and revoke rules and regulations for its administration. The Board, in the
exercise of this power, may correct any defect, omission or inconsistency in the Plan, in a manner
and to the extent it shall deem necessary or expedient to make the Plan fully effective.

               (iv) To amend the Plan as provided in paragraph 14.

               (v) Generally, to exercise such powers and to perform such acts as the Board deems necessary
or expedient to promote the best interests of the Company and its Subsidiaries and to carry out the
intent that the Plan be treated as an Employee Stock Purchase Plan.

          (c) The Board may delegate administration of the Plan to a Committee of the Board composed of
two (2) or more members, all of the members of which Committee may be, in the discretion of the
Board, Non-Employee Directors and/or Outside Directors. If administration is delegated to a
Committee, the Committee shall have, in connection with the administration of the Plan, the powers
theretofore possessed by the Board, including the power to delegate to a subcommittee of two (2) or
more Outside Directors any of the administrative powers the Committee is authorized to exercise
(and references in this Plan to the Board shall thereafter be to the Committee or such a
subcommittee), subject, however, to such resolutions, not inconsistent with the provisions of the
Plan, as may be adopted from time to time by the Board. The Board may abolish the Committee at any
time and revest in the Board the administration of the Plan. If administration is delegated to a
Committee, references to the Board in this Plan and in the Offering document shall thereafter be
deemed to be to the Board or the Committee, as the case may be.

          (d) Any interpretation of the Plan by the Board of any decision made by it under the Plan
shall be final and binding on all persons.

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     4. Shares Subject to the Plan.

          (a) Subject to the provisions of paragraph 13 relating to adjustments upon changes in stock,
the stock that may be sold pursuant to Purchase Rights granted under the Plan (the “Reserved
Shares”), shall not exceed in the aggregate five hundred thousand (500,000) shares of the Common
Stock. As of each January 1, beginning with January 1, 2007, and continuing through and including
January 1, 2016, the number of Reserved Shares will be increased automatically by the lesser of (i)
one percent (1.0%) of the total number of shares of the Common Stock outstanding on
such December 31st of the preceding calendar year, or (ii) two hundred fifty thousand (250,000) shares. Notwithstanding the foregoing, the
Board may designate a smaller number of shares to be added to the share reserve as of a particular
January 1. If any Purchase Right granted under the Plan shall for any reason terminate without
having been exercised, the Common Stock not purchased under such Purchase Right shall again become
available for the Plan.

          (b) The stock subject to the Plan may be unissued shares or reacquired shares, bought on the
market or otherwise.

     5. Grant of Rights; Offering.

          (a) The Board or the Committee may from time to time grant or provide for the grant of
Purchase Rights under the Plan to Eligible Employees in an Offering on an Offering Date or Offering
Dates selected by the Board or the Committee. Each Offering shall be in such form and shall
contain such terms and conditions as the Board or the Committee shall deem appropriate, which shall
comply with the requirements of Section 423(b)(5) of the Code that all Employees granted Purchase
Rights under the Plan shall have the same rights and privileges. The terms and conditions of an
Offering shall be incorporated by reference into the Plan and treated as part of the Plan. The
provisions of separate Offerings need not be identical, but each Offering shall include (through
incorporation of the provisions of this Plan by reference in the document comprising the Offering
or otherwise) the period during which the Offering shall be effective, which period shall not
exceed twenty-seven (27) months beginning with the Offering Date, and the substance of the
provisions contained in paragraphs 6 through 9, inclusive.

          (b) If a Participant has more than one (1) Purchase Right outstanding under the Plan, unless
he or she otherwise indicates in agreements or notices delivered hereunder, a Purchase Right with a
lower exercise price (or an earlier-granted Purchase Right if two (2) Purchase Rights have
identical exercise prices), will be exercised to the fullest possible extent before a Purchase
Right with a higher exercise price (or a later-granted Purchase Right if two (2) Purchase Rights
have identical exercise prices) will be exercised.

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     6. Eligibility.

          (a) Rights may be granted only to Employees of the Company or, as the Board or the Committee
may designate as provided in subparagraph 3(b), to Employees of any Subsidiary of the Company.
Except as provided in subparagraph 6(b), an Employee of the Company or any Subsidiary shall not be
eligible to be granted Purchase Rights under the Plan unless, on the Offering Date, such Employee
has been in the employ of the Company or any Subsidiary for such continuous period preceding such
grant as the Board or the Committee may require, but in no event shall the required period of
continuous employment be greater than two (2) years. In addition, unless otherwise determined by
the Board or the Committee and set forth in the terms of the applicable Offering, no Employee of
the Company or any Subsidiary shall be eligible to be granted Purchase Rights under the Plan
unless, on the Offering Date, such Employee’s customary employment with the Company or such
Subsidiary is for at least twenty (20) hours per week and at least five (5) months per calendar
year.

          (b) The Board or the Committee may provide that each person who, during the course of an
Offering, first becomes an Eligible Employee of the Company or designated Subsidiary will, on a
date or dates specified in the Offering which coincides with the day on which such person becomes
an Eligible Employee or a date which occurs thereafter, receive a Purchase Right under that
Offering, which Purchase Right shall thereafter be deemed to be a part of that Offering. Such
Purchase Right shall have the same characteristics as any Purchase Rights originally granted under
that Offering, as described herein, except that:

               (i) the date on which such Purchase Right is granted shall be the “Offering Date” of such
Purchase Right for all purposes, including determination of the exercise price of such Purchase
Right;

               (ii) the period of the Offering with respect to such Purchase Right shall begin on its
Offering Date and end coincident with the end of such Offering; and

               (iii) the Board or the Committee may provide that if such person first becomes an Eligible
Employee within a specified period of time before the end of the Offering, he or she will not
receive any Purchase Right under that Offering.

          (c) No Employee shall be eligible for the grant of any Purchase Rights under the Plan if,
immediately after any such Purchase Rights are granted, such Employee owns stock possessing five
percent (5%) or more of the total combined voting power or value of all classes of stock of the
Company or of any Related Corporation. For purposes of this subparagraph 6(c), the rules of
Section 424(d) of the Code shall apply in determining the stock ownership of any Employee, and
stock which such Employee may purchase under all outstanding Purchase Rights and options (whether
vested or unvested) shall be treated as stock owned by such Employee.

          (d) An Eligible Employee may be granted Purchase Rights under the Plan only if such Purchase
Rights, together with any other Purchase Rights granted under Employee Stock Purchase Plans of the
Company and any Related Corporations do not permit such

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Employee’s Purchase Rights or any Related Corporation to accrue at a rate which exceeds twenty
five thousand dollars ($25,000) of Fair Market Value of such stock (determined at the time such
Purchase Rights are granted) for each calendar year in which such Purchase Rights are outstanding
at any time.

          (e) Officers of the Company and any designated Subsidiary shall be eligible to participate in
Offerings under the Plan; provided, however, that the Board may provide in an Offering that certain
Employees who are highly compensated Employees within the meaning of Section 423(b)(4)(D) of the
Code shall not be eligible to participate.

     7. Rights; Purchase Price.

          (a) On each Offering Date, each Eligible Employee, pursuant to an Offering made under the
Plan, shall be granted a Purchase Right to purchase up to the number of shares of Common Stock of
the Company purchasable with a percentage designated by the Board or the Committee not exceeding
twenty percent (20%) of such Employee’s Earnings during the period which begins on the Offering
Date (or such later date as the Board or the Committee determines for a particular Offering) and
ends on the date stated in the Offering, which date shall be no later than the end of the Offering.
The Board or the Committee shall establish one (1) or more Purchase Dates during an Offering on
which Purchase Rights granted under the Plan shall be exercised and purchases of Common Stock
carried out in accordance with such Offering.

          (b) In connection with each Offering made under the Plan, the Board or the Committee may
specify a maximum number of shares that may be purchased by any Participant as well as a maximum
aggregate number of shares that may be purchased by all Participants pursuant to such Offering. In
addition, in connection with each Offering that contains more than one (1) Purchase Date, the Board
or the Committee may specify a maximum aggregate number of shares which may be purchased by all
Participants on any given Purchase Date under the Offering. If the aggregate purchase of shares
upon exercise of Purchase Rights granted under the Offering would exceed any such maximum aggregate
number, the Board or the Committee shall make a pro rata allocation of the shares available in as
nearly a uniform manner as shall be practicable and as it shall deem to be equitable.

          (c) The per share purchase price of stock acquired pursuant to Purchase Rights granted under
the Plan shall be not less than the lesser of:

               (i) an amount equal to eighty-five percent (85%) of the Fair Market Value of a share of Common
Stock on the Offering Date; or

               (ii) an amount equal to eighty-five percent (85%) of the Fair Market Value of a share of
Common Stock on the Purchase Date.

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     8. Participation; Withdrawal; Termination.

          (a) A Participant may elect to authorize payroll deductions pursuant to an Offering under the
Plan by completing and delivering to the Company, within the time specified in the Offering, an
enrollment form (in such form as the Company may provide). Each such enrollment form shall
authorize an amount of Contributions expressed as a percentage of the submitting Participant’s
Earnings during the Offering (not to exceed any maximum percentage or amount specified by the
Board). Each Participant’s Contributions shall be credited to a bookkeeping account for such
Participant under the Plan and shall be deposited with the general funds of the Company except
where applicable law requires that Contributions be deposited with a third party. To the extent
provided in the Offering, a Participant may begin such Contributions after the beginning of the
Offering. To the extent provided in the Offering, a Participant may thereafter reduce (including
to zero) or increase his or her Contributions.

          (b) During an Offering, a Participant may cease making Contributions and withdraw from the
Offering by delivering to the Company a notice of withdrawal in such form as the Company may
provide. Such withdrawal may be elected at any time prior to the end of the Offering, except as
provided otherwise in the Offering. Upon such withdrawal from the Offering by a Participant, the
Company shall distribute to such Participant all of his or her accumulated Contributions (reduced
to the extent, if any, such deductions have been used to acquire shares of Common Stock for the
Participant) under the Offering, and such Participant’s Purchase Rights in that Offering shall
thereupon terminate. A Participant’s withdrawal from an Offering shall have no effect upon such
Participant’s eligibility to participate in any other Offerings under the Plan, but such
Participant shall be required to deliver a new enrollment form in order to participate in
subsequent Offerings.

          (c) Rights granted pursuant to any Offering under the Plan shall terminate immediately upon a
Participant ceasing to be an Employee for any reason or for no reason (subject to any
post-employment participation period required by law) or other lack of eligibility. The Company
shall distribute to such terminated or otherwise ineligible Employee all of his or her accumulated
Contributions (reduced to the extent, if any, such deductions have been used to acquire shares of
Common Stock for the terminated or otherwise ineligible Employee) under the Offering.

          (d) Rights shall not be transferable by a Participant otherwise than by will or the laws of
descent and distribution, or by a beneficiary designation as provided in Section 15 and, during a
Participant’s lifetime, shall be exercisable only by such Participant.

          (e) Unless otherwise specified in an Offering, the Company shall have no obligation to pay
interest on Contributions.

          (f) Notwithstanding any other provision of this Plan, in connection with the Initial Offering,
each Eligible Employee who is employed on the date the Company’s Common Stock is first offered to
the public under a registration statement declared effective under the Securities Act automatically
shall be enrolled in the Initial Offering, with a Purchase Right for

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that number of shares of Common Stock purchasable with 20% of the Eligible Employee’s
Earnings, subject to any limitations set forth in the Offering. Following the filing of an
effective registration statement pursuant to a Form S-8, such Eligible Employee shall be provided a
certain period of time, as determined by the Company in its sole discretion, within which to elect
to authorize payroll deductions for the purchase of shares during the Initial Offering (which may
be for a percentage that is less than 20% of the Eligible Employee’s Earnings). If such Eligible
Employee elects not to authorize such payroll deductions, the Eligible Employee instead may
purchase shares of Common Stock under the Plan by delivering a single cash payment for the purchase
of such shares to the Company prior to the ten (10) day period (or such shorter period of time as
determined by the Company and communicated to Participants) immediately preceding the Purchase Date
under the Initial Offering. If an Eligible Employee neither elects to authorize payroll deductions
nor chooses to make a cash payment in accordance with the foregoing sentence, then the Eligible
Employee shall not purchase any shares of Common Stock during the Initial Offering. After the end
of the Initial Offering, in order to participate in any subsequent Offerings, an Eligible Employee
must enroll and authorize payroll deductions prior to the commencement of the Offering; provided,
however, that once an Eligible Employee enrolls in an Offering and authorizes payroll deductions
(including in connection with the Initial Offering), the Eligible Employee automatically shall be
enrolled for all subsequent Offerings until he or she elects to withdraw from an Offering, as
provided in paragraph (b) above, or terminates his or her participation in the Plan, as provided in
paragraph (c) above.

     9. Exercise.

          (a) On each Purchase Date specified therefor in the relevant Offering, each Participant’s
accumulated payroll deductions and other additional payments specifically provided for in the
Offering (without any increase for interest) will be applied to the purchase of whole shares of
stock of the Company, up to the maximum number of shares permitted pursuant to the terms of the
Plan and the applicable Offering, at the purchase price specified in the Offering. No fractional
shares shall be issued upon the exercise of Purchase Rights granted under the Plan. The amount, if
any, of accumulated payroll deductions remaining in each Participant’s account after the purchase
of shares which is less than the amount required to purchase one share of Common Stock on the final
Purchase Date of an Offering shall be held in each such Participant’s account for the purchase of
shares under the next Offering under the Plan, unless such Participant withdraws from such next
Offering, as provided in subparagraph 8(b), or is no longer eligible to be granted Purchase Rights
under the Plan, as provided in paragraph 6, in which case such amount shall be distributed to the
Participant after such final Purchase Date, without interest. The amount, if any, of accumulated
payroll deductions remaining in any Participant’s account after the purchase of shares which is
equal to the amount required to purchase one or more whole shares of Common Stock on the final
Purchase Date of an Offering shall be distributed in full to the Participant after such Purchase
Date, without interest.

          (b) No Purchase Rights granted under the Plan may be exercised to any extent unless the shares
to be issued upon such exercise under the Plan (including Purchase Rights

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granted thereunder) are covered by an effective registration statement pursuant to the
Securities Act and the Plan is in material compliance with all applicable state, foreign and other
securities and other laws applicable to the Plan. If on a Purchase Date in any Offering hereunder
the Plan is not so registered or in such compliance, no Purchase Rights granted under the Plan or
any Offering shall be exercised on such Purchase Date, and the Purchase Date shall be delayed until
the Plan is subject to such an effective registration statement and such compliance, except that
the Purchase Date shall not be delayed more than twelve (12) months and the Purchase Date shall in
no event be more than twenty-seven (27) months from the Offering Date. If on the Purchase Date of
any Offering hereunder, as delayed to the maximum extent permissible, the Plan is not registered
and in such compliance, no Purchase Rights granted under the Plan or any Offering shall be
exercised and all payroll deductions accumulated during the Offering (reduced to the extent, if
any, such deductions have been used to acquire stock) shall be distributed to the participants,
without interest.

     10. Covenants of the Company.

          (a) During the terms of the Purchase Rights granted under the Plan, the Company shall keep
available at all times the number of shares of Common Stock required to satisfy such Purchase
Rights, provided that the Company shall not be obligated to keep available shares in excess of the
limits set forth or described in paragraphs 4 and 7 of the Plan and any corresponding or additional
limits set forth in an Offering.

          (b) The Company shall seek to obtain from each federal, state, foreign or other regulatory
commission or agency having jurisdiction over the Plan such authority as may be required to issue
and sell shares of stock upon exercise of the Purchase Rights granted under the Plan. If, after
reasonable efforts, the Company is unable to obtain from any such regulatory commission or agency
the authority which counsel for the Company deems necessary for the lawful issuance and sale of
stock under the Plan, the Company shall be relieved from any liability for failure to issue and
sell stock upon exercise of such Purchase Rights unless and until such authority is obtained.

     11. Use of Proceeds from Stock.

     Proceeds from the sale of stock pursuant to Purchase Rights granted under the Plan shall
constitute general funds of the Company.

     12. Rights as a Stockholder.

     A Participant shall not be deemed to be the holder of, or to have any of the rights of a
holder with respect to, any shares subject to Purchase Rights granted under the Plan unless and
until the participant’s shareholdings acquired upon exercise of Purchase Rights under the Plan are
recorded in the books of the Company (or its transfer agent).

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     13. Adjustments upon Changes in Stock; Corporate Transactions.

               (a) If any change is made in the stock subject to the Plan, or subject to any Purchase Rights
granted under the Plan (through merger, consolidation, reorganization, recapitalization, stock
dividend, dividend in property other than cash, stock split, liquidating dividend, combination of
shares, exchange of shares, change in corporate structure or other transaction not involving the
receipt of consideration by the Company), the Plan and outstanding Purchase Rights will be
appropriately adjusted in the class(es) and maximum number of shares subject to the Plan and the
class(es) and number of shares and price per share of stock subject to outstanding Purchase Rights.
Such adjustments shall be made by the Board or the Committee, the determination of which shall be
final, binding and conclusive. (The conversion of any convertible securities of the Company shall
not be treated as a “transaction not involving the receipt of consideration by the Company.”)

               (b) In the event of a Corporate Transaction, then: (i) any surviving or acquiring corporation
may continue or assume Purchase Rights outstanding under the Plan or may substitute similar rights
(including a right to acquire the same consideration paid to stockholders in the Corporate
Transaction) for those outstanding under the Plan, or (ii) if any surviving or acquiring
corporation does not continue or assume such Purchase Rights or does not substitute similar rights
for Purchase Rights outstanding under the Plan, then, the Participants’ accumulated Contributions
shall be used to purchase shares of Common Stock within five (5) business days prior to the
Corporate Transaction under the ongoing Offering, and the Participants’ Purchase Rights under the
ongoing Offering shall terminate immediately after such purchase.

     14. Amendment of the Plan or Offerings.

               (a) The Board at any time, and from time to time, may amend the Plan or the terms of one or
more Offerings. However, except as provided in paragraph 13 relating to adjustments upon changes
in stock, no amendment shall be effective unless approved by the stockholders of the Company within
the time and to the extent stockholder approval is necessary for the Plan to satisfy the
requirements of Section 423 of the Code or other applicable laws or regulations. It is expressly
contemplated that the Board may amend the Plan or an Offering in any respect the Board deems
necessary or advisable to provide Eligible Employees with the maximum benefits provided or to be
provided under the provisions of the Code and the regulations promulgated thereunder relating to
Employee Stock Purchase Plans and/or to bring the Plan and/or Purchase Rights granted under an
Offering into compliance therewith.

               (b) The Board may, in its sole discretion, submit any amendment to the Plan or an Offering for
stockholder approval.

               (c) Purchase Rights and obligations under any Purchase Rights granted before amendment of the
Plan or Offering shall not be impaired by any amendment of the Plan, except with the consent of the
person to whom such Purchase Rights were granted, or except as necessary to comply with any laws or
governmental regulations, or except as necessary to ensure

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that the Plan and/or Purchase Rights granted under an Offering comply with the requirements of
Section 423 of the Code.

     15. Designation of Beneficiary.

               (a) A Participant may file a written designation of a beneficiary who is to receive any shares
and cash, if applicable, from the Participant’s account under the Plan in the event of such
Participant’s death subsequent to the end of an Offering but prior to delivery to the participant
of such shares and cash. In addition, a Participant may file a written designation of a
beneficiary who is to receive any cash from the Participant’s account under the Plan in the event
of such Participant’s death during an Offering.

               (b) Such designation of beneficiary may be changed by the Participant at any time by written
notice in the form prescribed by the Company. In the event of the death of a Participant and in
the absence of a beneficiary validly designated under the Plan who is living (or if an entity, is
otherwise in existence) at the time of such Participant’s death, the Company shall deliver such
shares and/or cash to the executor or administrator of the estate of the Participant, or if no such
executor or administrator has been appointed (to the knowledge of the Company), the Company, in its
sole discretion, may deliver such shares and/or cash to the spouse or to any one (1) or more
dependents or relatives of the Participant, or if no spouse, dependent or relative is known to the
Company, then to such other person as the Company may determine.

     16. Termination or Suspension of the Plan.

               (a) The Board in its discretion, may suspend or terminate the Plan at any time. Unless sooner
terminated, the Plan shall terminate on the day before the tenth (10th) anniversary of
the date the Plan is adopted by the Board. The Plan shall automatically terminate if all the
shares subject to the Plan pursuant to subparagraph 4(a) are issued. No Purchase Rights may be
granted under the Plan while the Plan is suspended or after it is terminated.

               (b) Rights and obligations under any Purchase Rights granted while the Plan is in effect shall
not be impaired by suspension or termination of the Plan, except as expressly provided in the Plan
or with the consent of the person to whom such Purchase Rights were granted, or except as necessary
to comply with any laws or governmental regulation, or except as necessary to ensure that the Plan
and/or Purchase Rights granted under an Offering comply with the requirements of Section 423 of the
Code.

     17. Effective Date of Plan.

     The Plan shall become effective on the same day on which the Company’s registration statement
under the Securities Act with respect to the initial public offering of shares of the Company’s
Common Stock becomes effective (the “Effective Date”), but no Purchase Rights granted under the
Plan shall be exercised unless and until the Plan had been approved by the stockholders of the
Company within twelve (12) months before or after the date the Plan is adopted by the Board or the
Committee, which date may be prior to the Effective Date.

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     18. Miscellaneous Provisions.

               (a) All questions concerning the construction, validity and interpretation of this Plan shall
be governed by the law of the State of Delaware, without regard to such state’s conflict of laws
rules.

               (b) The Plan and Offering do not constitute an employment contract. Nothing in the Plan or in
the Offering shall in any way alter the at will nature of a Participant’s employment or be deemed
to create in any way whatsoever any obligation on the part of any Participant to continue in the
employ of the Company or a Related Corporation, or on the part of the Company or a Related
Corporation to continue the employment of a Participant.

14exv10w9

 

Exhibit
10.9

Alexza Pharmaceuticals, Inc.

2005 Employee Stock Purchase Plan

Offering

Adopted by the Board of Directors                     , 2005

     In this document, capitalized terms not otherwise defined shall have the same definitions of
such terms as in the Alexza Pharmaceuticals, Inc. 2005 Employee Stock Purchase Plan.

1. Grant; Offering Date.

     (a) The Board hereby authorizes a series of Offerings pursuant to the terms of this Offering
document.

     (b) The Initial Offering shall begin on [                    ], 2006 and shall end on [                    ], 2008,
unless terminated earlier as provided below. Thereafter, an Offering shall begin on the day after
the last Purchase Date of the immediately preceding Offering. The first day of an Offering is that
Offering’s “Offering Date.” Each Offering shall be twenty-four (24) months in duration, with four
(4) Purchase Periods each of which shall be six (6) months in length. Except as provided below, a
“Purchase Date” is the last day of a Purchase Period or of an Offering, as the case may be. The
Initial Offering shall consist of four (4) Purchase Periods, with the first Purchase Period ending
on [                    ], 2006, the second Purchase Period ending on [                    ], the third Purchase Period
ending on [                    ], and the fourth Purchase Period ending on [                    ], 2008.

     (c) Notwithstanding the foregoing: (i) if any Offering Date falls on a day that is not a
Trading Day, then such Offering Date shall instead fall on the next subsequent Trading Day, and
(ii) if any Purchase Date falls on a day that is not a Trading Day, then such Purchase Date shall
instead fall on the immediately preceding Trading Day.

     (d) Prior to the commencement of any Offering, the Board may change any or all terms of such
Offering and any subsequent Offerings. The granting of Purchase Rights pursuant to each Offering
hereunder shall occur on each respective Offering Date unless prior to such date (i) the Board
determines that such Offering shall not occur, or (ii) no shares of Common Stock remain available
for issuance under the Plan in connection with the Offering.

     (e) If the Company’s accountants advise the Company that the accounting treatment of purchases
under the Plan has changed in a manner that the Company determines is detrimental to its best
interests, then each Offering hereunder that is then ongoing shall terminate as of the next
Purchase Date (after the purchase of stock on such Purchase Date) under such Offering.

     (f) Notwithstanding anything in this Section 1 to the contrary, if on the first day of a new
Purchase Period during the Offering the Fair Market Value of a share of Common Stock is less than
it was on the Offering Date for that Offering, then that Offering shall immediately terminate and
that day shall become the Offering Date of a new Offering. Eligible Employees in

 

 

the terminated Offering shall automatically be enrolled in the new Offering that starts on
such day.

2. Eligible Employees.

     (a) Each Employee of the Company or of a Subsidiary incorporated in the United States on the
Offering Date of an Offering hereunder who has been an Employee of the Company or a Subsidiary for
a continuous period ending on the applicable Offering Date of at least ninety (90) days (an
“Eligible Employee”), shall be granted a Purchase Right on the Offering Date of such Offering.

     (b) Notwithstanding the foregoing, the following Employees shall not be Eligible
Employees or be granted Purchase Rights under an Offering:

          (i) part-time or seasonal Employees whose customary employment is less than twenty (20) hours
per week or less than five (5) months per calendar year;

          (ii) five percent (5%) stockholders (including ownership through unexercised and/or unvested
stock options) as described in Section 6(c) of the Plan; or

          (iii) Employees in jurisdictions outside of the United States if, as of the Offering Date of
the Offering, the grant of such Purchase Rights would not be in compliance with the applicable laws
of any jurisdiction in which the Employee resides or is employed.

     (c) Notwithstanding the foregoing, each person who first becomes an Eligible Employee during
an Offering shall receive, on the day after the first Purchase Date during that Offering, which
occurs after the date such person becomes an eligible employee, a Purchase Right under such
Offering, which Purchase Right shall thereafter be deemed to be a part of the Offering. Such
Purchase Right shall have the same characteristics as any Purchase Rights originally granted under
the Offering except that:

          (i) the date on which such Purchase Right is granted shall be the “Offering Date” of such
Purchase Right for all purposes except for the application of the provision of Section 1(f) above
(the application of which shall be determined only by using the Offering Date of the ongoing
Offering), including determination of the exercise price of such Purchase Right; and

          (ii) the Offering for such Purchase Right shall begin on its Offering Date and end coincident
with the end of the ongoing Offering.

3. Purchase Rights.

     (a) Subject to the limitations herein and the Plan, unless a lower percentage has been set by
the Board or a committee thereof prior to the commencement of the Offering, a Participant’s
Purchase Right shall permit the purchase of the number of shares of Common Stock purchasable with
up to twenty percent (20%) of such Participant’s Earnings paid during the period of such Offering
beginning immediately after such Participant first commences participation; provided, however, that
no Participant may have more than twenty percent (20%)

2

 

of such Participant’s Earnings applied to purchase shares of Common Stock under all ongoing
Offerings under the Plan and all other plans of the Company and Related Corporations that are
intended to qualify as Employee Stock Purchase Plans.

     (b) For Offerings hereunder, “Earnings” means the base compensation paid to an Eligible
Employee, including all salary and wages (including amounts elected to be deferred by such Eligible
Employee, that would otherwise have been paid, under any cash or deferred arrangement or other
deferred compensation program established by the Company or a Related Corporation), but excluding
overtime pay, commissions, bonuses, and other remuneration paid directly to such Eligible Employee,
profit sharing, the cost of employee benefits paid for by the Company or a Related Corporation,
education or tuition reimbursements, imputed income arising under any Company or Related
Corporation group insurance or benefit program, traveling expenses, business and moving expense
reimbursements, income received in connection with stock options, contributions made by the Company
or a Related Corporation under any employee benefit plan, and similar items of compensation.

     (c) Notwithstanding the foregoing, the maximum number of shares of Common Stock that a
Participant may purchase on any Purchase Date in an Offering shall be such number of shares as has
a Fair Market Value (determined as of the Offering Date for such Offering) equal to (x) $25,000
multiplied by the number of calendar years in which the Purchase Right under such Offering has been
outstanding at any time, minus (y) the Fair Market Value of any other shares of Common Stock
(determined as of the relevant Offering Date with respect to such shares) that, for purposes of the
limitation of Section 423(b)(8) of the Code, are attributed to any of such calendar years in which
the Purchase Right is outstanding. The amount in clause (y) of the previous sentence shall be
determined in accordance with regulations applicable under Section 423(b)(8) of the Code based on
(i) the number of shares previously purchased with respect to such calendar years pursuant to such
Offering or any other Offering under the Plan, or pursuant to any other Company or Related
Corporation plans intended to qualify as Employee Stock Purchase Plans, and (ii) the number of
shares subject to other Purchase Rights outstanding on the Offering Date for such Offering pursuant
to the Plan or any other such Company or Related Corporation Employee Stock Purchase Plan.

     (d) The maximum aggregate number of shares of Common Stock available to be purchased by all
Participants under an Offering shall be the number of shares of Common Stock remaining available
under the Plan on the Offering Date. If the aggregate purchase of shares of Common Stock upon
exercise of Purchase Rights granted under the Offering would exceed the maximum aggregate number of
shares available, the Board shall make a pro rata allocation of the shares available in a uniform
and equitable manner.

     (e) Notwithstanding the foregoing, the maximum number of shares of Common Stock that a
Participant may purchase on any Purchase Date during any Offering shall not exceed Ten Thousand
(10,000) shares.

4. Purchase Price.

     The purchase price of shares of Common Stock under an Offering shall be the lesser of: (i)
eighty-five percent (85%) of the Fair Market Value of such shares of Common Stock on the

3

 

applicable Offering Date, or (ii) eighty-five percent (85%) of the Fair Market Value of such
shares of Common Stock on the applicable Purchase Date, in each case rounded up to the nearest
whole cent per share.

5. Participation.

     (a) If an Eligible Employee intends to participate in an Offering, such Eligible Employee
shall elect his or her payroll deduction percentage on such enrollment form as the Company
provides. The completed enrollment form must be delivered to the Company prior to the Offering
Date of the applicable Offering, unless a later time for filing the enrollment form is set by the
Company for all Eligible Employees with respect to a given Offering. Payroll deduction percentages
must be expressed in whole percentages of Earnings, with a minimum percentage of one percent (1%)
and a maximum percentage of twenty percent (20%). Except as provided in paragraph (e) below with
respect to the Initial Offering, Contributions may be made only by way of payroll deductions.

     (b) A Participant may increase or decrease his or her participation level during a Purchase
Period. A Participant may increase or decrease (including a decrease to zero percent (0%)) his or
her participation level only once during a Purchase Period. Any such increase or decrease in
participation level shall be made by delivering a notice to the Company or a designated Subsidiary
in such form as the Company provides prior to the ten (10) day period (or such shorter period of
time as determined by the Company and communicated to Participants) immediately preceding the next
Purchase Date of the Purchase Period for which it is to be effective.

     (c) A Participant may withdraw from an Offering and receive a refund of his or her
Contributions (reduced to the extent, if any, such Contributions have been used to acquire shares
of Common Stock for the Participant on any prior Purchase Date) without interest, at any time prior
to the end of the Offering, excluding only each ten (10) day period immediately preceding a
Purchase Date (or such shorter period of time determined by the Company and communicated to
Participants), by delivering a withdrawal notice to the Company or a designated Subsidiary in such
form as the Company provides. A Participant who has withdrawn from an Offering shall not again
participate in such Offering, but may participate in subsequent Offerings under the Plan in
accordance with the terms of the Plan and the terms of such subsequent Offerings.

     (d) Notwithstanding the foregoing or any other provision of this Offering document or of the
Plan to the contrary, neither the enrollment of any Eligible Employee in the Plan nor any forms
relating to participation in the Plan shall be given effect until such time as a registration
statement covering the registration of the shares under the Plan that are subject to the Offering
has been filed by the Company and has become effective.

     (e) Notwithstanding the foregoing or any other provision of this Offering document or of the
Plan to the contrary, with respect to the Initial Offering only, each Eligible Employee who is
employed on the Initial Offering Date automatically shall be enrolled in the Initial Offering, with
a Purchase Right to purchase up to the number of shares of Common Stock that are purchasable with
20% of the Eligible Employee’s Earnings, subject to the limitations set forth in Section 3(c)-(f)
above. Each Eligible Employee shall be provided a certain period of

4

 

time, as determined by the Company in its sole discretion, within which to elect to authorize
payroll deductions for the purchase of shares during the Initial Offering (which may be for a
percentage that is less than or equal to 20% of the Eligible Employee’s Earnings). If an Eligible
Employee elects not to authorize payroll deductions, then the Eligible Employee shall not purchase
any shares of Common Stock during the Initial Offering. After the end of the Initial Offering, in
order to participate in any subsequent Offerings, an Eligible Employee must enroll and authorize
payroll deductions prior to the commencement of the Offering, in accordance with paragraph (a)
above; provided, however, that once an Eligible Employee enrolls in an Offering and authorizes
payroll deductions (including in connection with the Initial Offering), the Eligible Employee
automatically shall be enrolled for all subsequent Offerings until he or she elects to withdraw
from an Offering pursuant to paragraph (c) above or terminates his or her participation in the
Plan.

6. Purchases.

     Subject to the limitations contained herein, on each Purchase Date, each Participant’s
Contributions (without any increase for interest) shall be applied to the purchase of whole shares,
up to the maximum number of shares permitted under the Plan and the Offering.

7. Notices and Agreements.

     Any notices or agreements provided for in an Offering or the Plan shall be given in writing,
in a form provided by the Company, and unless specifically provided for in the Plan or this
Offering, shall be deemed effectively given upon receipt or, in the case of notices and agreements
delivered by the Company, five (5) days after deposit in the United States mail, postage prepaid.

8. Exercise Contingent on Stockholder Approval.

     (a) The Purchase Rights granted under an Offering are subject to the approval of the Plan by
the stockholders of the Company as required for the Plan to obtain treatment as an Employee Stock
Purchase Plan.

9. Offering Subject to Plan.

     Each Offering is subject to all the provisions of the Plan, and the provisions of the Plan are
hereby made a part of the Offering. The Offering is further subject to all interpretations,
amendments, rules and regulations which may from time to time be promulgated and adopted pursuant
to the Plan. In the event of any conflict between the provisions of an Offering and those of the
Plan (including interpretations, amendments, rules and regulations which may from time to time be
promulgated and adopted pursuant to the Plan), the provisions of the Plan shall control.

5

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