Document:

EX-10.19

 Exhibit 10.19 
 LEASE 
 by and between 

BMR-325 VASSAR STREET LLC, 
 a Delaware limited liability company 
 and 

BIND BIOSCIENCES, INC., 
 a Delaware corporation 
 BMR form dated 3/16/11 

 LEASE 

THIS LEASE (this “Lease”) is entered into as of this 20th day of July, 2011 (the “Execution Date”), by and
between BMR-325 VASSAR STREET LLC, a Delaware limited liability company (“Landlord”), and BIND BIOSCIENCES, INC., a Delaware corporation (“Tenant”). 

RECITALS 
 A. WHEREAS, Landlord owns certain real property (the “Property”) and the improvements on the Property located at 325 Vassar Street, Cambridge, Massachusetts, including the building
located thereon; and 
 B. WHEREAS, Landlord wishes to lease to Tenant, and Tenant desires to lease from
Landlord, certain premises (the “Premises”) located on the first (1st) and second (2nd) floors of the building in which the Premises are located (the “Building”), pursuant to the terms and conditions of this Lease, as detailed below. 

AGREEMENT 
 NOW, THEREFORE, Landlord and Tenant, in consideration of the mutual promises contained herein and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged,
and intending to be legally bound, agree as follows: 
 1. Lease of Premises. 

1.1. Effective on the Term Commencement Date, Landlord hereby leases to Tenant, and Tenant hereby leases from Landlord, the Premises, as
shown on Exhibit A attached hereto, including exclusive shafts, cable runs, mechanical spaces and rooftop areas, for use by Tenant in accordance with the Permitted Use (as defined below) and no other uses. The Property and all landscaping,
parking facilities, private drives and other improvements and appurtenances related thereto, including the Building, are hereinafter collectively referred to as the “Project.” All portions of the Project that are for the
non-exclusive use of tenants of the Building, including driveways, sidewalks, parking areas, landscaped areas, service corridors, stairways, elevators, public restrooms and public lobbies, are hereinafter referred to as “Common
Area.” 
 2. Basic Lease Provisions. For convenience of the parties, certain basic provisions of this Lease are set forth
herein. The provisions set forth herein are subject to the remaining terms and conditions of this Lease and are to be interpreted in light of such remaining terms and conditions. 

2.1. This Lease shall take effect upon the Execution Date and, except as specifically otherwise provided within this Lease, each of the
provisions hereof shall be binding upon and inure to the benefit of Landlord and Tenant from the date of execution and delivery hereof by all parties hereto. 

 2.2. In the definitions below, each current Rentable Area (as defined below) is expressed in
rentable square footage. Rentable Area and “Tenant’s Pro Rata Share” are both subject to adjustment as provided in this Lease. 
  

					
	 Definition or Provision
	  	Means the Following (As of the Term
Commencement Date)	 
	 Approximate Rentable Area of Premises
	  	 	32,784 square feet	  
	 Approximate Rentable Area of Project
	  	 	61,011 square feet	  
	 Tenant’s Pro Rata Share of Project
	  	 	53.73%	  

 2.3. Initial monthly and annual installments of Base Rent for the Premises (“Base Rent”)
as of the Rent Commencement Date (as defined below), subject to adjustment under this Lease: 
  

															
	 Square Feet of
Rentable Area
	 	 	Base Rent per Square Foot of
Rentable Area	 	 	Monthly Base
Rent	 	 	Annual Base
Rent	 
	 	32,784	  	 	 	$44 annually	  	 	 	$120,208	  	 	 	$1,442,496	  

 2.4. Estimated Term Commencement Date: April 1, 2012 

2.5. Estimated Term Expiration Date: April 30, 2017 
 2.6. Security Deposit: $480,832 
 2.7. Permitted Use: Office and laboratory use in
conformity with all federal, state, municipal and local laws, codes, ordinances, rules and regulations of Governmental Authorities (as defined below), committees, associations, or other regulatory committees, agencies or governing bodies having
jurisdiction over the Premises, the Building, the Property, the Project, Landlord or Tenant, including both statutory and common law and hazardous waste rules and regulations (“Applicable Laws”) 

 

			
	2.8. Address for Rent Payment:	  	BMR-325 Vassar Street LLC
		  	Unit N
		  	P.O. Box 51919
		  	Los Angeles, California 90051-6219

  
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	2.9. Address for Notices to Landlord:	  	BMR-325 Vassar Street LLC
		  	17190 Bernardo Center Drive
		  	San Diego, California 92128
		  	Attn: Vice President, Real Estate Counsel
		
	2.10. Address for Notices to Tenant:	  	

 Prior to the Term Commencement Date: 

			
		
		  	BIND Biosciences, Inc.
		  	64 Sidney Street
		  	Cambridge, Massachusetts 02139
		  	Attn: Andrea Franz

 From and After the Term Commencement Date: 

			
		
		  	BIND Biosciences, Inc.
		  	325 Vassar Street
		  	Cambridge, Massachusetts 02139
		  	Attn: Andrea Franz

 2.11. The following Exhibits are attached hereto and incorporated herein by reference: 

 

			
	Exhibit A	  	Premises
	Exhibit B	  	Work Letter
	Exhibit C	  	Acknowledgement of Term Commencement Date and Term Expiration Date
	Exhibit D	  	Location of Liquid Nitrogen Tank
	Exhibit E	  	Form of Letter of Credit
	Exhibit F	  	Rules and Regulations
	Exhibit G	  	[Intentionally Omitted]
	Exhibit H	  	Tenant’s Personal Property
	Exhibit I	  	Form of Estoppel Certificate

 3. Term. The actual term of this Lease (as the same may be extended pursuant to Article 42 hereof or
otherwise, and as the same may be earlier terminated in accordance with this Lease, the “Term”) shall commence on the actual Term Commencement Date (as defined in Article 4) and end on April 30, 2017 (such date, the
“Term Expiration Date”), subject to earlier termination of this Lease as provided herein. 
 4. Possession and Commencement
Date. 
 4.1 The “Term Commencement Date” shall be the earlier of (a) the Estimated Term Commencement
Date and (b) the day the work described in the Work Letter (the “Tenant Improvements”) is Substantially Complete and Tenant is in receipt of a temporary or permanent certificate of occupancy. Tenant shall execute and deliver to
Landlord written acknowledgment of the actual Term Commencement Date and the Term Expiration Date within ten (10) days after 

  
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Tenant takes occupancy of the Premises, in the form attached as Exhibit C hereto. Failure to execute and deliver such acknowledgment, however, shall not affect the Term Commencement Date
or Landlord’s or Tenant’s liability hereunder. Failure by Tenant to obtain validation by any medical review board or other similar governmental licensing of the Premises required for the Permitted Use by Tenant shall not serve to extend
the Term Commencement Date. The term “Substantially Complete” or “Substantial Completion” means that the Tenant Improvements are substantially complete in accordance with the Approved Plans (as defined in the Work
Letter), except for minor punch list items. 
 4.2 Tenant shall cause the Tenant Improvements to be constructed in the Premises
pursuant to the Work Letter attached hereto as Exhibit B (the “Work Letter”) at a cost to Landlord not to exceed Two Million Four Hundred Fifty-Eight Eight Hundred Dollars ($2,458,800) (based upon Seventy-Five Dollars ($75)
per square foot of Rentable Area (as defined below)) (the “TI Allowance”). The TI Allowance may be applied to the costs of (n) construction, (o) project review by Landlord (which fee shall equal the actual cost to Landlord
for all third party expenses related to Landlord’s review of the Tenant Improvements), (p) space planning, architect, engineering and other related services performed by third parties unaffiliated with Tenant, (q) building permits and
other taxes, fees, charges and levies by Governmental Authorities (as defined below) for permits or for inspections of the Tenant Improvements, (r) costs and expenses for labor, material, equipment and fixtures, and (s) costs and expenses
for data/telecom cabling, moving and furniture; provided, however, that Tenant may not apply more than Three Hundred Twenty-Seven Thousand Eight Hundred Forty Dollars ($327,840) (based upon Ten Dollars ($10) per square foot of Rentable Area)
of the TI Allowance towards the costs and expenses set forth in Subsection 4.2(s). In no event shall the TI Allowance be used for (v) the cost of work that is not authorized by the Approved Plans (as defined in the Work Letter) or
otherwise approved in writing by Landlord, (w) payments to Tenant or any affiliates of Tenant, (x) the purchase of any furniture, personal property or other non-building system equipment, (y) costs resulting from any default by Tenant
of its obligations under this Lease or (z) costs that are recoverable by Tenant from a third party (e.g., insurers, warrantors, or tortfeasors). 
 4.3 Tenant shall have until the date (the “TI Deadline”) that is eighteen (18) months after the Execution Date to expend the unused portion of the TI Allowance, after which date
Landlord’s obligation to fund such costs shall expire. 
 4.4 In no event shall any unused TI Allowance entitle Tenant to a
credit against Rent payable under this Lease. Tenant shall deliver to Landlord (i) a certificate of occupancy for the Premises suitable for the Permitted Use and (ii) a Certificate of Substantial Completion in the form of the American
Institute of Architects document G704, executed by the project architect and the general contractor. 
 4.5 Prior to entering
upon the Premises, Tenant shall furnish to Landlord evidence satisfactory to Landlord that insurance coverages required of Tenant under the provisions of Article 23 are in effect, and such entry shall be subject to all the terms and
conditions of this Lease other than the payment of Base Rent. 
 4.6 The architect, engineering consultants, design team,
general contractor and subcontractors responsible for the construction of the Tenant Improvements shall be selected by 

  
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Tenant and approved by Landlord, which approval Landlord shall not unreasonably withhold, condition or delay. Landlord may refuse to use any architects, consultants, contractors, subcontractors
or material suppliers that Landlord reasonably believes are likely to cause labor disharmony. 
 4.7 During construction of the
Tenant Improvements, Tenant shall use power from current meter(s) that exclusively service the Premises or shall install temporary meters for all water, gas, electricity and other utilities supplied to the first floor Premises for use during
Tenant’s construction of the Tenant Improvements and until the Term Commencement Date. Tenant shall pay all utility charges, together with any fees, surcharges and taxes thereon, beginning on the Execution Date (which costs are eligible for
reimbursement through the TI Allowance). 
 5. Condition of Premises. Tenant acknowledges that, except as set forth herein, neither
Landlord nor any agent of Landlord has made any representation or warranty with respect to the condition of the Premises, the Building or the Project, or with respect to the suitability of the Premises, the Building or the Project for the conduct of
Tenant’s business. Tenant acknowledges that (a) it is familiar with the condition of the Premises and agrees to take the same in its condition “as is” as of the Execution Date and (b) Landlord shall have no obligation to
alter, repair or otherwise prepare the Premises for Tenant’s occupancy or to pay for or construct any improvements to the Premises, except with respect to the TI Allowance. Tenant’s taking of possession of the Premises shall, except as
otherwise set forth herein, conclusively establish that the Premises, the Building and the Project were at such time in good, sanitary and satisfactory condition and repair. 
 6. Rentable Area. 
 6.1. The term “Rentable Area” shall
reflect such areas as reasonably calculated by Landlord’s architect, as the same may be reasonably adjusted from time to time by Landlord in consultation with Landlord’s architect to reflect changes to the Premises, the Building or the
Project, as applicable. Notwithstanding the foregoing, in no event shall Base Rent or Tenant’s Pro Rata Share hereunder be increased as a result of any such adjustment. 
 6.2. The Rentable Area of the Building is generally determined by making separate calculations of Rentable Area applicable to each floor within the Building and totaling the Rentable Area of all floors
within the Building. The Rentable Area of a floor is computed by measuring to the outside finished surface of the permanent outer Building walls. The full area calculated as previously set forth is included as Rentable Area, without deduction for
columns and projections or vertical penetrations, including stairs, elevator shafts, flues, pipe shafts, vertical ducts and the like, as well as such items’ enclosing walls. 

6.3. The term “Rentable Area,” when applied to the Premises, is that area equal to the usable area of the Premises, plus
an equitable allocation of Rentable Area within the Building that is not then utilized or expected to be utilized as usable area, including that portion of the Building devoted to corridors, equipment rooms, restrooms, elevator lobby, atrium and
mailroom. 

  
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 7. Rent. 
 7.1. Tenant shall pay to Landlord as Base Rent for the Premises, commencing on May 1, 2012 (the “Rent Commencement Date”), the sums set forth in Section 2.3, subject to
the rental adjustments provided in Article 8 hereof. Base Rent shall be paid in equal monthly installments as set forth in Section 2.3, subject to the rental adjustments provided in Article 8 hereof, each in advance on the
first day of each and every calendar month during the Term. 
 7.2. In addition to Base Rent, Tenant shall pay to Landlord as
additional rent (“Additional Rent”) at times hereinafter specified in this Lease (a) Tenant’s Share (as defined below) of Operating Expenses (as defined below), (b) the Property Management Fee (as defined below) and
(c) any other amounts that Tenant assumes or agrees to pay under the provisions of this Lease that are owed to Landlord, including any and all other sums that may become due by reason of any default of Tenant or failure on Tenant’s part to
comply with the agreements, terms, covenants and conditions of this Lease to be performed by Tenant, after notice and the lapse of any applicable cure periods. 
 7.3. Base Rent and Additional Rent shall together be denominated “Rent.” Rent shall be paid to Landlord, without abatement, deduction or offset, in lawful money of the United States of
America at the office of Landlord as set forth in Section 2.8 or to such other person or at such other place as Landlord may from time designate in writing. In the event the Term commences or ends on a day other than the first day of a
calendar month, then the Rent for such fraction of a month shall be prorated for such period on the basis of a thirty (30) day month and shall be paid at the then-current rate for such fractional month. 

8. Rent Adjustments. Base Rent shall be subject to an annual upward adjustment of three percent (3%) of the then-current
Base Rent. The first such adjustment shall become effective commencing on the first (1st) annual anniversary of the Term Commencement Date, and subsequent adjustments shall become effective on every successive annual anniversary for so long as this Lease continues in effect. 

9. Operating Expenses. 

9.1. As used herein, the term “Operating Expenses” shall include: 

(a) Government impositions including property tax costs consisting of real and personal property taxes and assessments, including amounts
due under any improvement bond upon the Building or the Project, including the parcel or parcels of real property upon which the Building and areas serving the Building are located or assessments in lieu thereof imposed by any federal, state,
regional, local or municipal governmental authority, agency or subdivision (each, a “Governmental Authority”) are levied; taxes on or measured by gross rentals received from the rental of space in the Project; taxes based on the
square footage of the Premises, the Building or the Project, as well as any parking charges, utilities surcharges or any other costs levied, assessed or imposed by, or at the direction of, or resulting from Applicable Laws or interpretations
thereof, promulgated by any Governmental Authority in connection with the use or occupancy of the Project or the parking facilities serving the Project; taxes on this transaction or any document to which Tenant is a party creating or transferring an
interest in the 

  
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Premises; any fee for a business license to operate an office building; and any expenses, including the reasonable cost of attorneys or experts, reasonably incurred by Landlord in seeking
reduction by the taxing authority of the applicable taxes, less tax refunds obtained as a result of an application for review thereof. Operating Expenses shall not include any net income, franchise, capital stock, estate or inheritance taxes, or
taxes that are the personal obligation of Tenant or of another tenant of the Project; and 
 (b) All other costs of any kind
paid or incurred by Landlord in connection with the operation or maintenance of the Building and the Project, including costs of repairs and replacements to improvements within the Project as appropriate to maintain the Project as required
hereunder, including costs of funding such reasonable reserves as Landlord, consistent with good business practice, may establish to provide for future repairs and replacements; costs of utilities furnished to the Common Areas; sewer fees; cable
television; trash collection; cleaning, including windows; heating; ventilation; air-conditioning; maintenance of landscaping and grounds; maintenance of drives and parking areas; maintenance of the roof; security services and devices; building
supplies; maintenance or replacement of equipment utilized for operation and maintenance of the Project; license, permit and inspection fees; sales, use and excise taxes on goods and services purchased by Landlord in connection with the operation,
maintenance or repair of the Building or Project systems and equipment; telephone, postage, stationery supplies and other expenses incurred in connection with the operation, maintenance or repair of the Project; accounting, legal and other
professional fees and expenses incurred in connection with the Project; costs of replacement, in due course, of furniture, draperies, carpeting, landscaping and other customary and ordinary items of personal property provided by Landlord for use in
Common Areas; the applicable portion of Permitted Capital Expenditures (as defined and detailed below); costs of complying with Applicable Laws (except to the extent such costs are incurred to remedy non-compliance as of the Execution Date with
Applicable Laws); costs to keep the Project in compliance with, or fees otherwise required under, any CC&Rs (as defined below); insurance premiums, including premiums for public liability, property casualty, earthquake, terrorism and
environmental coverages; portions of insured losses paid by Landlord as part of the deductible portion of a loss pursuant to the terms of insurance policies; service contracts; costs of services of independent contractors retained to do work of a
nature referenced above; and costs of compensation (including employment taxes and fringe benefits) of all persons who perform regular and recurring duties connected with the day-to-day operation and maintenance of the Project, its equipment, the
adjacent walks, landscaped areas, drives and parking areas, including janitors, floor waxers, window washers, watchmen, gardeners, sweepers and handymen. “Permitted Capital Expenditures” shall mean all capital expenditures
(i) for maintaining, repairing and replacing obsolete equipment, (ii) for the primary purpose of reducing Operating Expenses or (iii) required by any Governmental Authority to comply with Applicable Laws (but not to remedy
non-compliance as of the Execution Date with Applicable Laws). The cost of Permitted Capital Expenditures, including interest thereon, shall be amortized over the useful life of the improvements made or items purchased as determined by generally
accepted accounting principles, and each year the applicable portion shall be included as Operating Expenses. 
 Notwithstanding
the foregoing, Operating Expenses shall not include any leasing commissions; expenses that relate to preparation of rental space for a tenant; expenses of initial development and construction, including grading, paving, landscaping and decorating
(as 

  
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distinguished from maintenance, repair and replacement of the foregoing); legal expenses relating to other tenants; capital expenses other than the portion of Permitted Capital Expenditures
permitted by the preceding paragraph; costs of repairs to the extent reimbursed by payment of insurance proceeds received by Landlord; interest upon loans to Landlord or secured by a mortgage or deed of trust covering the Project or a portion
thereof (provided that interest upon a government assessment or improvement bond payable in installments shall constitute an Operating Expense under Subsection 9.1(a)); salaries of executive officers of Landlord; depreciation claimed
by Landlord for tax purposes (provided that this exclusion of depreciation is not intended to delete from Operating Expenses actual costs of repairs and replacements and reasonable reserves in regard thereto that are provided for in
Subsection 9.1(b)); taxes that are excluded from Operating Expenses by the last sentence of Subsection 9.1(a); and costs incurred by Landlord for renovation and refurbishment projects for the Common Area and interior furnishings
completed prior to the Execution Date, including Permitted Capital Expenditures incurred as a part thereof. To the extent that Tenant uses more than Tenant’s Pro Rata Share of any item of Operating Expenses, Tenant shall pay Landlord for such
excess in addition to Tenant’s obligation to pay Tenant’s Pro Rata Share of Operating Expenses (such excess, together with Tenant’s Pro Rata Share, “Tenant’s Share”). 

9.2. Tenant shall pay to Landlord on the first day of each calendar month of the Term, as Additional Rent, (a) the Property
Management Fee (as defined below) and (b) Landlord’s estimate of Tenant’s Share of Operating Expenses with respect to the Building and the Project, as applicable, for such month. 

(x) The “Property Management Fee” shall equal three percent (3%) of Base Rent due from Tenant. Tenant shall pay the
Property Management Fee in accordance with Section 9.2 with respect to the entire Term, including any extensions thereof or any holdover periods, regardless of whether Tenant is obligated to pay Base Rent, Operating Expenses or any other
Rent with respect to any such period or portion thereof. 
 (y) Within ninety (90) days after the conclusion of each
calendar year (or such longer period as may be reasonably required by Landlord), Landlord shall furnish to Tenant a statement showing in reasonable detail the actual Operating Expenses and Tenant’s Share of Operating Expenses for the previous
calendar year. Any additional sum due from Tenant to Landlord shall be immediately due and payable. If the amounts paid by Tenant pursuant to this Section exceed Tenant’s Share of Operating Expenses for the previous calendar year, then Landlord
shall credit the difference against the Rent next due and owing from Tenant; provided that, if the Lease term has expired, Landlord shall accompany said statement with payment for the amount of such difference. 

(z) Any amount due under this Section for any period that is less than a full month shall be prorated (based on a thirty (30)-day month)
for such fractional month. 
 9.3. Tenant shall be responsible for Operating Expenses from the Rent Commencement Date.
Tenant’s responsibility for Tenant’s Share of Operating Expenses shall continue to the latest of (x) the date of termination of the Lease, (y) the date Tenant has fully vacated the Premises and (z) if termination of the
Lease is due to a default by Tenant, as contemplated by Article 31 hereof. 

  
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 9.4. Operating Expenses for the calendar year in which Tenant’s obligation to share
therein commences and for the calendar year in which such obligation ceases shall be prorated on a basis reasonably determined by Landlord. Expenses such as taxes, assessments and insurance premiums that are incurred for an extended time period
shall be prorated based upon the time periods to which they apply so that the amounts attributed to the Premises relate in a reasonable manner to the time period wherein Tenant has an obligation to share in Operating Expenses. 

9.5. Within five (5) business days after the end of each calendar month, Tenant shall submit to Landlord an invoice, or, in the
event an invoice is not available, an itemized list, of all costs and expenses that (a) Tenant has incurred (either internally or by employing third parties) during the prior month and (b) for which Tenant reasonably believes it is
entitled to reimbursements from Landlord pursuant to the terms of this Lease or that Tenant reasonably believes is the responsibility of Landlord pursuant to this Lease or the Work Letter. 

9.6. In the event that the Building or Project is less than fully leased, Tenant acknowledges that Landlord may extrapolate Operating
Expenses that vary depending on the occupancy of the Building or Project, as applicable, by dividing (a) the total cost of such Operating Expenses by (b) the quotient of (i) the Rentable Area of the Building or Project (as applicable)
that is leased divided by (ii) the Rentable Area of the Building or Project (as applicable), then multiplying (y) the resulting quotient ((a) divided by (b)) by (z) ninety-five percent (95%), then multiplying the product ((y) times
(z)) by Tenant’s Pro Rata Share. In no event shall Landlord shall not recover more than one hundred percent (100%) of Operating Expenses. 
 9.7. Within ninety (90) days after the conclusion of each calendar year (or such longer period as may be reasonably required by Landlord), Landlord shall furnish to Tenant a statement (the
“Statement”) showing in reasonable detail the actual Operating Expenses and Tenant’s Pro Rata Share of Operating Expenses for the previous calendar year. Any additional sum due from Tenant to Landlord shall be due and payable within
thirty (30) days after Tenant’s receipt of the Statement. If the amounts paid by Tenant pursuant to this Section exceed Tenant’s Pro Rata Share of Operating Expenses for the previous calendar year, then Landlord shall credit the
difference against the Rent next due and owing from Tenant; provided that, if the Term has expired, Landlord shall accompany such statement with payment for the amount of the difference. Within forty-five (45) days after Tenant’s
receipt of the Statement (and in no event more often than once in any one (1) year period), Tenant may review, at Tenant’s sole cost and expense, the books and records supporting the Statement in an office of Landlord or Landlord’s
agent during normal business hours, upon giving Landlord ten (10) days’ advance written notice. If Tenant utilizes an independent accountant to perform such review, such accountant shall (a) be one of national standing, (b) be
reasonably acceptable to Landlord and (c) not be compensated on a contingency basis. In the event that Tenant’s review of Landlord’s records indicate that Tenant has underpaid or overpaid Tenant’s Pro Rata Share of Operating
Expenses, Tenant and Landlord shall make appropriate payments or credits as provided above. If Landlord and Tenant determine that Landlord overcharged Tenant for Operating Expenses for the calendar year in question by five percent (5%) or more,
Landlord shall be required to reimburse Tenant for any reasonable third party audit costs incurred by Tenant in accordance with this Section. 

  
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 10. Taxes on Tenant’s Property. 

10.1. Tenant shall pay prior to delinquency any and all taxes levied against any personal property or trade fixtures placed by Tenant in
or about the Premises. 
 10.2. If any such taxes on Tenant’s personal property or trade fixtures are levied against
Landlord or Landlord’s property or, if the assessed valuation of the Building, the Property or the Project is increased by inclusion therein of a value attributable to Tenant’s personal property or trade fixtures, and if Landlord, after
written notice to Tenant, pays the taxes based upon any such increase in the assessed value of the Building, the Property or the Project, then Tenant shall, upon demand, repay to Landlord the taxes so paid by Landlord. 

10.3. If any improvements in or alterations to the Premises, whether owned by Landlord or Tenant and whether or not affixed to the real
property so as to become a part thereof, are assessed for real property tax purposes at a valuation higher than the valuation at which improvements conforming to Landlord’s building standards (the “Building Standard”) in other
spaces in the Building are assessed, then the real property taxes and assessments levied against Landlord or the Building, the Property or the Project by reason of such excess assessed valuation shall be deemed to be taxes levied against personal
property of Tenant and shall be governed by the provisions of Section 10.2. Any such excess assessed valuation due to improvements in or alterations to space in the Project leased by other tenants at the Project shall not be included in
Operating Expenses. If the records of the County Assessor are available and sufficiently detailed to serve as a basis for determining whether said Tenant improvements or alterations are assessed at a higher valuation than the Building Standard, then
such records shall be binding on both Landlord and Tenant. 
 11. Security Deposit. 

11.1. Tenant shall deposit with Landlord on or before the Execution Date the sum set forth in Section 2.6 (the
“Security Deposit”), which sum shall be held by Landlord as security for the faithful performance by Tenant of all of the terms, covenants and conditions of this Lease to be kept and performed by Tenant during the period commencing
on the Execution Date and ending upon the expiration or termination of Tenant’s obligations under this Lease. If Tenant defaults with respect to any provision of this Lease, including any provision relating to the payment of Rent, then Landlord
may (but shall not be required to) use, apply or retain all or any part of the Security Deposit for the payment of any Rent or any other sum in default, or to compensate Landlord for any other loss or damage that Landlord may suffer by reason of
Tenant’s default. If any portion of the Security Deposit is so used or applied, then Tenant shall, within ten (10) days following demand therefor, deposit cash with Landlord in an amount sufficient to restore the Security Deposit to its
original amount, and Tenant’s failure to do so shall be a material breach of this Lease. The provisions of this Article shall survive the expiration or earlier termination of this Lease. 

11.2. In the event of bankruptcy or other debtor-creditor proceedings against Tenant, the Security Deposit shall be deemed to be applied
first to the payment of Rent and other charges due Landlord for all periods prior to the filing of such proceedings. 

  
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 11.3. Landlord may deliver to any purchaser of Landlord’s interest in the Premises the
funds deposited hereunder by Tenant, and thereupon Landlord shall be discharged from any further liability with respect to such deposit. This provision shall also apply to any subsequent transfers. 

11.4. If Tenant shall fully and faithfully perform every provision of this Lease to be performed by it, then the Security Deposit, or any
balance thereof, shall be returned to Tenant (or, at Landlord’s option, to the last assignee of Tenant’s interest hereunder) within thirty (30) days after the expiration or earlier termination of this Lease. 

11.5. If the Security Deposit shall be in cash, Landlord shall hold the Security Deposit in an account at a banking organization selected
by Landlord; provided, however, that Landlord shall not be required to maintain a separate account for the Security Deposit, but may intermingle it with other funds of Landlord. Landlord shall be entitled to all interest and/or dividends, if
any, accruing on the Security Deposit. Landlord shall not be required to credit Tenant with any interest for any period during which Landlord does not receive interest on the Security Deposit. 

11.6. The Security Deposit may be in the form of cash, a letter of credit or any other security instrument acceptable to Landlord in its
sole discretion. Tenant may at any time, except when Tenant is in Default (as defined below), deliver a letter of credit (the “L/C Security”) as the entire Security Deposit, as follows: 

(a) If Tenant elects to deliver L/C Security, then Tenant shall provide Landlord, and maintain in full force and effect throughout the
Term and until the date that is six (6) months after the then-current Term Expiration Date, a letter of credit in the form of Exhibit E issued by an issuer reasonably satisfactory to Landlord, in the amount of the Security Deposit, with
an initial term of at least one year. Landlord may require the L/C Security to be re-issued by a different issuer at any time during the Term if Landlord reasonably believes that the issuing bank of the L/C Security is or may soon become insolvent;
provided, however, Landlord shall return the existing L/C Security to the existing issuer immediately upon receipt of the substitute L/C Security. If any issuer of the L/C Security shall become insolvent or placed into FDIC receivership, then Tenant
shall immediately deliver to Landlord (without the requirement of notice from Landlord) substitute L/C Security issued by an issuer reasonably satisfactory to Landlord, and otherwise conforming to the requirements set forth in this Article. As used
herein with respect to the issuer of the L/C Security, “insolvent” shall mean the determination of insolvency as made by such issuer’s primary bank regulator (i.e., the state bank supervisor for state chartered banks; the OCC
or OTS, respectively, for federally chartered banks or thrifts; or the Federal Reserve for its member banks). If, at the Term Expiration Date, any Rent remains uncalculated or unpaid, then: (i) Landlord shall with reasonable diligence complete
any necessary calculations; (ii) Tenant shall extend the expiry date of such L/C Security from time to time as Landlord reasonably requires; and (iii) in such extended period, Landlord shall not unreasonably refuse to consent to an
appropriate reduction of the L/C Security. Tenant shall reimburse Landlord’s reasonable out-of-pocket legal costs in handling Landlord’s acceptance of L/C Security or its replacement or extension. 

  
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 (b) If Tenant delivers to Landlord satisfactory L/C Security in place of the entire Security
Deposit, Landlord shall remit to Tenant any cash Security Deposit Landlord previously held. 
 (c) Landlord may draw upon the
L/C Security, and hold and apply the proceeds in the same manner and for the same purposes as the Security Deposit, if: (i) an uncured Default (as defined below) exists; (ii) as of the date forty-five (45) days before any L/C Security
expires (even if such scheduled expiry date is after the Term Expiration Date) Tenant has not delivered to Landlord an amendment or replacement for such L/C Security, reasonably satisfactory to Landlord, extending the expiry date to the earlier of
(1) six (6) months after the then-current Term Expiration Date or (2) the date one year after the then-current expiry date of the L/C Security; (iii) the L/C Security provides for automatic renewals, Landlord asks the issuer to
confirm the current L/C Security expiry date, and the issuer fails to do so within ten (10) business days; (iv) Tenant fails to pay (when and as Landlord reasonably requires) any bank charges for Landlord’s transfer of the L/C
Security; or (v) the issuer of the L/C Security ceases, or announces that it will cease, to maintain an office in the city where Landlord may present drafts under the L/C Security (and fails to permit drawing upon the L/C Security by overnight
courier or facsimile). This Section does not limit any other provisions of this Lease allowing Landlord to draw the L/C Security under specified circumstances. 
 (d) Tenant shall not seek to enjoin, prevent, or otherwise interfere with Landlord’s draw under L/C Security, even if it violates this Lease. Tenant acknowledges that the only effect of a wrongful
draw would be to substitute a cash Security Deposit for L/C Security, causing Tenant no legally recognizable damage. Landlord shall hold the proceeds of any draw in the same manner and for the same purposes as a cash Security Deposit. In the event
of a wrongful draw, the parties shall cooperate to allow Tenant to post replacement L/C Security simultaneously with the return to Tenant of the wrongfully drawn sums, and Landlord shall upon request confirm in writing to the issuer of the L/C
Security that Landlord’s draw was erroneous. 
 (e) If Landlord transfers its interest in the Premises, then Tenant shall
at Tenant’s expense, within five (5) business days after receiving a request from Landlord, deliver (and, if the issuer requires, Landlord shall consent to) an amendment to the L/C Security naming Landlord’s grantee as substitute
beneficiary. If the required Security Deposit changes while L/C Security is in force, then Tenant shall deliver (and, if the issuer requires, Landlord shall consent to) a corresponding amendment to the L/C Security. 

12. Use. 
 12.1. Tenant
shall use the Premises for the purpose set forth in Section 2.7, and shall not use the Premises, or permit or suffer the Premises to be used, for any other purpose without Landlord’s prior written consent, which consent Landlord may
withhold in its sole and absolute discretion. 
 12.2. Tenant shall not use or occupy the Premises in violation of Applicable
Laws; zoning ordinances; or the certificate of occupancy issued for the Building or the Project, and shall, upon five (5) days’ written notice from Landlord, discontinue any use of the Premises that is declared or claimed by any
Governmental Authority having jurisdiction to be a violation of 

  
 12 

 
any of the above, or that in Landlord’s reasonable opinion violates any of the above. Tenant shall comply with any direction of any Governmental Authority having jurisdiction that shall, by
reason of the nature of Tenant’s use or occupancy of the Premises, impose any duty upon Tenant or Landlord with respect to the Premises or with respect to the use or occupation thereof. 

12.3. Tenant shall not do or permit to be done anything that will invalidate or increase the cost of any fire, environmental, extended
coverage or any other insurance policy covering the Building or the Project, and shall comply with all rules, orders, regulations and requirements of the insurers of the Building and the Project, and Tenant shall promptly, upon demand, reimburse
Landlord for any additional premium charged for such policy by reason of Tenant’s failure to comply with the provisions of this Article. 
 12.4. Tenant shall keep all doors opening onto public corridors closed, except when in use for ingress and egress. 
 12.5. No additional locks or bolts of any kind shall be placed upon any of the doors or windows by Tenant, nor shall any changes be made to existing locks or the mechanisms thereof without Landlord’s
prior written consent. Tenant shall, upon termination of this Lease, return to Landlord all keys to offices and restrooms either furnished to or otherwise procured by Tenant. In the event any key so furnished to Tenant is lost, Tenant shall pay to
Landlord the cost of replacing the same or of changing the lock or locks opened by such lost key if Landlord shall deem it necessary to make such change. 
 12.6. No awnings or other projections shall be attached to any outside wall of the Building. No curtains, blinds, shades or screens shall be attached to or hung in, or used in connection with, any window
or door of the Premises other than Landlord’s standard window coverings. Neither the interior nor exterior of any windows shall be coated or otherwise sunscreened without Landlord’s prior written consent, nor shall any bottles, parcels or
other articles be placed on the windowsills. No equipment, furniture or other items of personal property shall be placed on any exterior balcony without Landlord’s prior written consent. 

12.7. No sign, advertisement or notice (“Signage”) shall be exhibited, painted or affixed by Tenant on any part of the
Premises or the Building without Landlord’s prior written consent. Signage shall conform to Landlord’s design criteria. For any Signage, Tenant shall, at Tenant’s own cost and expense, (a) acquire all permits for such Signage in
compliance with Applicable Laws and (b) design, fabricate, install and maintain such Signage in a first-class condition. Tenant shall be responsible for reimbursing Landlord for costs incurred by Landlord in removing any of Tenant’s
Signage upon the expiration or earlier termination of the Lease. Interior signs on doors and the directory tablet shall be inscribed, painted or affixed for Tenant by Landlord at Tenant’s sole cost and expense, and shall be of a size, color and
type and be located in a place acceptable to Landlord. The directory tablet shall be provided exclusively for the display of the name and location of tenants only. Tenant shall not place anything on the exterior of the corridor walls or corridor
doors other than Landlord’s standard lettering. At Landlord’s option, Landlord may install any Tenant Signage, and Tenant shall pay all costs associated with such installation within thirty (30) days after demand therefor. Tenant, at
its sole cost and expense, shall have the right to install exterior Building signage (which may include Tenant’s registered corporate logo), subject to all applicable laws and Landlord’s reasonable approval. Notwithstanding the

  
 13 

 
foregoing, Landlord, at its sole cost and expense (and not to be included in Operating Expenses), shall provide Tenant with Building standard Signage on all Building directories and at the
entrance to the Premises. 
 12.8. Tenant shall only place equipment within the Premises with floor loading consistent with the
Building’s structural design without Landlord’s prior written approval, and such equipment shall be placed in a location designed to carry the weight of such equipment. 

12.9. Tenant shall cause any equipment or machinery to be installed in the Premises so as to reasonably prevent sounds or vibrations
therefrom from extending into the Common Areas or other offices in the Project. 
 12.10. Tenant shall not (a) do or permit
anything to be done in or about the Premises that shall in any way obstruct or interfere with the rights of other tenants or occupants of the Project, or injure or annoy them, (b) use or allow the Premises to be used for immoral, unlawful or
objectionable purposes, (c) cause, maintain or permit any nuisance or waste in, on or about the Project or (d) take any other action that would in Landlord’s reasonable determination in any manner adversely affect other tenants’
quiet use and enjoyment of their space or adversely impact their ability to conduct business in a professional and suitable work environment. 
 12.11. Notwithstanding any other provision herein to the contrary, Tenant shall be responsible for all liabilities, costs and expenses arising out of or in connection with the compliance of the Premises
with the Americans with Disabilities Act, 42 U.S.C. § 12101, et seq., and any state and local accessibility laws, codes, ordinances and rules (collectively, and together with regulations promulgated pursuant thereto, the
“ADA”), and Tenant shall indemnify, save, defend (at Landlord’s option and with counsel reasonably acceptable to Landlord) and hold Landlord and its affiliates, employees, agents and contractors; and any lender, mortgagee or
beneficiary (each, a “Lender” and, collectively with Landlord and its affiliates, employees, agents and contractors, the “Landlord Indemnitees”) harmless from and against any demands, claims, liabilities, losses,
costs, expenses, actions, causes of action, damages or judgments, and all reasonable expenses (including reasonable attorneys’ fees, charges and disbursements) incurred in investigating or resisting the same (collectively,
“Claims”), excluding consequential damages, arising out of any such failure of the Premises to comply with the ADA. Notwithstanding the foregoing, and without limiting Tenant’s responsibilities under this Section, at the time
of Landlord’s delivery of the Premises, all base building systems (including HVAC, electrical, life safety and plumbing) shall be in good working condition and suitable for laboratory and office uses, the Premises and Building common areas
(except for mechanical spaces) will be compliant with the ADA, and the Premises’ demising walls and Common Area corridors will be in compliance with the local municipal building code. This Section (as well as any other provisions of this Lease
dealing with indemnification of the Landlord Indemnitees by Tenant shall be deemed to be modified in each case by the insertion in the appropriate place of the following: “except as otherwise provided in Mass. G.L. Ter. Ed., C. 186,
Section 15.” The provisions of this Section shall survive the expiration or earlier termination of this Lease. 

12.12. Tenant shall establish and maintain a chemical safety program administered by a licensed, qualified individual in accordance with
the requirements of the Massachusetts Water Resources Authority (“MWRA”) and any other applicable Governmental Authority. Tenant 

  
 14 

 
shall be solely responsible for all costs incurred in connection with such chemical safety program, and Tenant shall provide Landlord with such documentation as Landlord may reasonably require
evidencing Tenant’s compliance with the requirements of (a) the MWRA and any other applicable Governmental Authority with respect to such chemical safety program and (b) this Section. Notwithstanding the foregoing, Landlord shall
obtain and maintain during the Term (m) any permit required by the MWRA (“MWRA Permit”) to operate the Acid Neutralization Tank (as defined below) and (n) a wastewater treatment operator license from the Commonwealth of
Massachusetts with respect to Tenant’s use of the Acid Neutralization Tank in the Building. Tenant shall not introduce anything into the Acid Neutralization Tank (x) in violation of the terms of the MWRA Permit, (y) in violation of
Applicable Laws or (z) that would interfere with the proper functioning of the Acid Neutralization Tank. Tenant agrees to reasonably cooperate with Landlord in order to obtain the MWRA Permit and the wastewater treatment operator license.
Tenant shall reimburse Landlord within ten (10) business days after demand for any costs incurred by Landlord pursuant to this Section. 

13. Rules and Regulations, CC&Rs, Parking Facilities and Common Areas. 

13.1. Tenant shall have the non-exclusive right, in common with others, to use the Common Areas, subject to the rules and regulations
adopted by Landlord and attached hereto as Exhibit F, together with such other reasonable and nondiscriminatory rules and regulations as are hereafter promulgated by Landlord in its sole and absolute discretion (the “Rules and
Regulations”). Tenant shall faithfully observe and comply with the Rules and Regulations. Landlord shall not be responsible to Tenant for the violation or non-performance by any other tenant or any agent, employee or invitee thereof of any
of the Rules and Regulations. 
 13.2. This Lease is subject to any recorded covenants, conditions or restrictions on the
Project or Property (the “CC&Rs”), as the same may be amended, amended and restated, supplemented or otherwise modified from time to time; provided that any such amendments, restatements, supplements or modifications do
not materially modify Tenant’s rights or obligations hereunder. Tenant shall comply with the CC&Rs. 
 13.3.

 (a) Tenant shall have a non-exclusive, irrevocable license to use, but shall not be obligated to use, the following
allocation of parking facilities serving the Project in common on an unreserved basis with other tenants of the Building during the Term and any extensions thereof pursuant to this Lease: (a) one-third (1/3) of a parking space per one
thousand (1,000) rentable square feet of space (the “Adjacent Lot Pro Rata Share”) and (b) two-thirds (2/3) of a parking space per one thousand (1,000) rentable square feet of space (the “Hyatt Pro Rata
Share”, and together with the Adjacent Lot Pro Rata Share, “Tenant’s Parking Pro Rata Share”). The Adjacent Lot Pro Rata Share shall be in the parking lot adjacent to the Building, depicted as the “Adjacent
Lot” on Exhibit D, and the Hyatt Pro Rata Share shall be in the Hyatt garage across the street. Simultaneously with payments of Base Rent, Tenant shall pay Landlord as Additional Rent for Tenant’s Parking Pro Rata Share at the rate
of One Hundred Dollars ($100.00) per space per month in the Adjacent Lot and One Hundred Eighty-Five Dollars ($185.00) per space per month in the Hyatt garage, which amounts may be increased by Landlord from time to time upon thirty
(30) days’ prior written notice from Landlord to Tenant 

  
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to reflect then-current market rent. Any parking spaces that may be granted to Tenant in addition to Tenant’s Parking Pro Rata Share shall be charged to Tenant at the then-current market
rent for such spaces. 
 (b) If and to the extent that Landlord is unable to make Tenant’s Parking Pro Rata Share, or any
portion thereof, available to Tenant in the parking lots set forth above (the “Unavailable Spaces”), Landlord shall make an equal number of parking spaces available in the Adjacent Lot (in the event that Landlord is unable to make
Tenant’s Hyatt Pro Rata Share available), if available, or, if spaces are not available in the Adjacent Lot, in the garage located at 47 Erie Street in Cambridge, Massachusetts (the “Erie Garage”), which Erie Garage is owned or
controlled by Landlord or an affiliate of Landlord; provided that, if the Unavailable Spaces become available at a future date during the Term, Landlord shall relocate Tenant’s parking spaces, on a pro rata basis with the other tenants
of the Building, from the Erie Garage back to the Adjacent Lot or the Hyatt garage. All parking spaces used by Tenant pursuant to this Section shall only be utilized by Tenant’s employees, visitors, sublessees or assignees visiting or working
at the Premises. 
 13.4. Landlord reserves the right to modify the Common Areas, including the right to add or remove exterior
and interior landscaping and to subdivide real property. Tenant acknowledges that Landlord specifically reserves the right to allow the exclusive use of corridors and restroom facilities located on specific floors to one or more tenants occupying
such floors; provided, however, that Tenant shall not be deprived of the use of the corridors reasonably required to serve the Premises or of restroom facilities serving the floor upon which the Premises are located. 

13.5. Subject to Section 16.8, Tenant shall have twenty-four (24) hour access to the freight elevators and the freight
loading docks of the Building, at no additional cost. 
 14. Project Control by Landlord. 

14.1. Landlord reserves full control over the Building and the Project to the extent not inconsistent with Tenant’s enjoyment of the
Premises as provided by this Lease. This reservation includes Landlord’s right to subdivide the Project; convert the Building to condominium units; change the size of the Project by selling all or a portion of the Project or adding real
property and any improvements thereon to the Project; grant easements and licenses to third parties; maintain or establish ownership of the Building separate from fee title to the Property; make additions to or reconstruct portions of the Building
and the Project; install, use, maintain, repair, replace and relocate for service to the Premises and other parts of the Building or the Project pipes, ducts, conduits, wires and appurtenant fixtures, wherever located in the Premises, the Building
or elsewhere at the Project; and alter or relocate any other Common Area or facility, including private drives, lobbies and entrances. 
 14.2. Possession of areas of the Premises necessary for utilities, services, safety and operation of the Building is reserved to Landlord. 

14.3. Tenant shall, at Landlord’s request, promptly execute such further documents as may be reasonably appropriate to assist
Landlord in the performance of its obligations hereunder; 

  
 16 

 
provided that Tenant need not execute any document that creates additional liability for Tenant or that deprives Tenant of the quiet enjoyment and use of the Premises as provided for in
this Lease. 
 14.4. Landlord may, at any and all reasonable times during non-business hours (or during business hours if Tenant
so requests), and upon twenty-four (24) hours’ prior notice (provided that no time restrictions shall apply or advance notice be required if an emergency necessitates immediate entry), enter the Premises to (a) inspect the same
and to determine whether Tenant is in compliance with its obligations hereunder, (b) supply any service Landlord is required to provide hereunder, (c) show the Premises to prospective purchasers or tenants during the final year of the
Term, (d) post notices of nonresponsibility, (e) access the telephone equipment, electrical substation and fire risers and (f) alter, improve or repair any portion of the Building other than the Premises for which access to the
Premises is reasonably necessary. At any time that Landlord or Landlord’s employees, contractors or agents enter the Premises pursuant hereto (other than in the case of emergency), upon request of Tenant such persons shall be accompanied by a
representative of Tenant at all times; provided that Tenant makes such representative reasonably available. In connection with any such alteration, improvement or repair as described in Subsection 14.4(f), Landlord may erect in the
Premises or elsewhere in the Project scaffolding and other structures reasonably required for the alteration, improvement or repair work to be performed. In no event shall Tenant’s Rent abate as a result of Landlord’s activities pursuant
to this Section; provided, however, that all such activities shall be conducted in such a manner so as to cause as little interference to Tenant as is reasonably possible. Landlord shall at all times retain a key with which to unlock all of
the doors in the Premises. If an emergency necessitates immediate access to the Premises, Landlord may use whatever force is necessary to enter the Premises, and any such entry to the Premises shall not constitute a forcible or unlawful entry to the
Premises, a detainer of the Premises, or an eviction of Tenant from the Premises or any portion thereof. 
 15. Quiet Enjoyment. So long
as Tenant is not in default under this Lease, Landlord or anyone acting through or under Landlord shall not disturb Tenant’s occupancy of the Premises, except as permitted by this Lease. 
 16. Utilities and Services. 
 16.1. Tenant shall pay
for all water (including the cost to service, repair and replace reverse osmosis, de-ionized and other treated water), gas, heat, light, power, telephone, internet service, cable television, other telecommunications and other utilities supplied to
the Premises, together with any fees, surcharges and taxes thereon. If any such utility is not separately metered to Tenant, (a) Tenant shall pay Tenant’s Share of all charges of such utility jointly metered with other premises as
Additional Rent or (b) in the alternative, Landlord may, at its option and sole cost (not to be included in Operating Expenses), install monitoring and metering equipment and monitor the usage of such utilities by Tenant. Notwithstanding
anything in this Lease to the contrary, Tenant shall install metering equipment to separately meter HVAC and electricity provided to the first (1st) floor Premises as part of the Tenant Improvements. Landlord shall reimburse Tenant, in addition to the TI Allowance,
for the reasonable cost of installing the metering equipment to separately meter electricity provided to the first
(1st) floor Premises (the “Landlord Metering
Cost”), provided that the Landlord Metering Cost shall not exceed Ten 

  
 17 

 
Thousand Dollars ($10,000). As a condition to reimbursement of the Landlord Metering Cost, Tenant shall submit to Landlord the documentation (with respect to the Landlord Metering Cost) required
in Section 6.3 of the Work Letter. To the extent that Tenant uses more than Tenant’s Pro Rata Share of any utilities, then Tenant shall pay Landlord Tenant’s Share of Operating Expenses to reflect such excess. In the event that
the Building or Project is less than fully leased, Tenant acknowledges that Landlord may extrapolate utility usage that varies depending on the occupancy of the Building or Project, as applicable, by dividing (a) the total cost of utility usage
by (b) the quotient of (i) the Rentable Area of the Building or Project (as applicable) that is leased divided by (ii) the Rentable Area of the Building or Project (as applicable), then multiplying (y) the resulting quotient ((a)
divided by (b)) by (z) ninety-five percent (95%), then multiplying the product ((y) times (z)) by Tenant’s Pro Rata Share. In no event shall Landlord shall not recover more than one hundred percent (100%) of such utility costs.

 16.2. Landlord shall not be liable for, nor shall any eviction of Tenant result from, the failure to furnish any utility or
service, whether or not such failure is caused by accident; breakage; repair; strike, lockout or other labor disturbance or labor dispute of any character; act of terrorism; shortage of materials, which shortage is not unique to Landlord or Tenant,
as the case may be; governmental regulation, moratorium or other governmental action, inaction or delay; or other causes beyond Landlord’s control (collectively, “Force Majeure”) or Landlord’s negligence. In the event of
such failure, Tenant shall not be entitled to termination of this Lease or any abatement or reduction of Rent, nor shall Tenant be relieved from the operation of any covenant or agreement of this Lease. 

16.3. Tenant shall pay for, prior to delinquency of payment therefor, any utilities and services that may be furnished to the Premises
during or, if Tenant occupies the Premises after the expiration or earlier termination of the Term, after the Term, beyond those utilities provided by Landlord, including telephone, internet service, cable television and other telecommunications,
together with any fees, surcharges and taxes thereon. 
 16.4. Tenant shall not, without Landlord’s prior written consent,
use any device in the Premises (including data processing machines) that will in any way (a) increase the amount of ventilation, air exchange, gas, steam, electricity or water required or consumed in the Premises based upon Tenant’s Pro
Rata Share of the Building or Project (as applicable) beyond the existing capacity of the Building or the Project usually furnished or supplied for the use set forth in Section 2.7 or (b) exceed Tenant’s Pro Rata Share of the
Building’s or Project’s (as applicable) capacity to provide such utilities or services. 
 16.5. If Tenant shall
require utilities or services in excess of those usually furnished or supplied for tenants in similar spaces in the Building or the Project by reason of Tenant’s equipment or extended hours of business operations, then Tenant shall first
procure Landlord’s consent for the use thereof, which consent Landlord may condition upon the availability of such excess utilities or services, and Tenant shall pay as Additional Rent an amount equal to the cost of providing such excess
utilities and services. 
 16.6. Upon Landlord’s demand, utilities and services provided to the Premises that are
separately metered shall be paid by Tenant directly to the supplier of such utility or service. 

  
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 16.7. Landlord shall provide water in Common Areas for lavatory purposes only, which water
shall be from the local municipal or similar source; provided, however, that if Landlord determines that Tenant requires, uses or consumes water for any purpose other than ordinary lavatory purposes, Landlord may install, at Landlord’s
expense, a water meter and thereby measure Tenant’s water consumption for all purposes. Tenant agrees to pay for water consumed, as shown on said meter, as and when bills are rendered. If Tenant fails to timely make such payments, Landlord may
pay such charges and collect the same from Tenant. Any such costs or expenses incurred, or payments made by Landlord for any of the reasons or purposes hereinabove stated, shall be deemed to be Additional Rent payment by Tenant and collectible by
Landlord as such. Landlord shall also make available reverse osmosis water, compressed air and vacuum systems for Tenant’s non-exclusive use in the Premises for the duration of the Term. Landlord shall maintain such systems, and the costs
incurred by Landlord in connection with the foregoing shall be Operating Expenses hereunder. 
 16.8. Landlord reserves the
right to stop service of the elevator, plumbing, ventilation, air conditioning and electric systems, when Landlord deems necessary or desirable, due to accident, emergency or the need to make repairs, alterations or improvements, until such repairs,
alterations or improvements shall have been completed, and Landlord shall further have no responsibility or liability for failure to supply elevator facilities, plumbing, ventilation, air conditioning or electric service when prevented from doing so
by Force Majeure; a failure by a third party to deliver gas, oil or another suitable fuel supply; or Landlord’s inability by exercise of reasonable diligence to obtain gas, oil or another suitable fuel. Without limiting the foregoing, it is
expressly understood and agreed that any covenants on Landlord’s part to furnish any service pursuant to any of the terms, covenants, conditions, provisions or agreements of this Lease, or to perform any act or thing for the benefit of Tenant,
shall not be deemed breached if Landlord is unable to furnish or perform the same by virtue of Force Majeure so long as Landlord is diligently pursuing the restoration of the same. 

16.9. The Building has two (2) back-up generators (each a “Generator” and, collectively, the
“Generators”). With respect to the portion of the Premises located on the first (1st) floor of the Building, Tenant shall be entitled to use up to its proportionate share of available power from the 250 kW Generator that services the first (1st) floor of the Building on a non-exclusive basis with other Tenants
on the first (1st) floor of the Building. With
respect to the portion of the Premises located on the second (2nd) floor of the Building, Tenant shall be entitled to use up to its proportionate share of available power from the 350 kW Generator that services the second (2nd) floor of the Building on a non-exclusive basis with other
Tenants on the second (2nd) floor of the Building.
The cost of maintaining, repairing and replacing the Generators shall constitute Operating Expenses. Landlord expressly disclaims any warranties with regard to the Generators or the installation thereof, including any warranty of merchantability or
fitness for a particular purpose. Landlord shall maintain the Generators in good working condition, but shall not be liable for any failure to make any repairs or to perform any maintenance that is an obligation of Landlord unless such failure shall
persist for an unreasonable time after Tenant provides Landlord with written notice of the need for such repairs or maintenance. The provisions of Section 16.2 of this Lease shall apply to the Generators. 

16.10. For the Premises, Landlord shall (a) maintain and operate the heating, ventilating and air conditioning systems used for the
Permitted Use only (“HVAC”) and (b) subject to 

  
 19 

 
clause (a) above, furnish HVAC as reasonably required (except as this Lease otherwise provides) for reasonably comfortable occupancy of the Premises twenty-four (24) hours a day, every
day during the Term, subject to casualty, eminent domain or as otherwise specified in this Article. Notwithstanding anything to the contrary in this Section, Landlord shall have no liability, and Tenant shall have no right or remedy, on account of
any interruption or impairment in HVAC services; provided that Landlord diligently endeavors to cure any such interruption or impairment. 
 16.11. [Intentionally omitted] 
 16.12. The Building is
currently serviced by a common laboratory waste sanitary sewer connection from the pH neutralization room on the first
(1st) floor of the Building to the municipal sewer line in
the street adjacent to the Building. There currently exists a separate acid neutralization tank that is connected to the portion of the Premises located on the first (1st) floor of the Building, as well as to adjacent premises on the first (1st) floor of the Building (the “Acid Neutralization
Tank”). Tenant shall have a non-exclusive right to use its proportionate share (based upon the Rentable Area of Premises located on the first (1st) floor of the Building) of the Acid Neutralization Tank in accordance with Applicable Laws in common with other
tenants on the first (1st) floor of the Building.
Tenant, as a portion of its Operating Expenses, shall reimburse Landlord for all costs, charges and expenses incurred by Landlord from time to time in connection with or arising out of the operation, use, maintenance, repair or refurbishment of the
Acid Neutralization Tank, including all clean-up costs relating to the Acid Neutralization Tank (collectively, “Tank Costs”); provided, however, that if the Acid Neutralization Tank is being used by other tenant(s) or
occupant(s) of the Building at any time during the Term, then, during such time period, Tenant shall only be obligated to pay its proportionate share of the Tank Costs. Notwithstanding the foregoing, in the event the Acid Neutralization Tank is
damaged or repairs to the Acid Neutralization Tank are required as a result of the improper use (including using more than Tenant’s proportionate share) of the Acid Neutralization Tank by Tenant, Tenant shall be responsible for one hundred
percent (100%) of the cost of any repairs or replacement required as a result of such improper use by Tenant, regardless of whether the Acid Neutralization Tank is then being used by other tenant(s) or occupant(s) of the Building. Similarly, if
the Acid Neutralization Tank is damaged, or if repairs to the Acid Neutralization Tank are required as a result of the improper use of the Acid Neutralization Tank by other tenant(s) or occupant(s) of the Building, then Tenant shall have no
responsibility for the cost of any repairs or replacements required as a result of such improper use by such other tenant(s) or occupant(s). Tenant shall indemnify, save, defend (at Landlord’s option and with counsel reasonably acceptable to
Landlord) and hold the Landlord Indemnitees harmless from and against any and all Claims, including (a) diminution in value of the Project or any portion thereof, (b) damages for the loss or restriction on use of rentable or usable space
or of any amenity of the Project, (c) damages arising from any adverse impact on marketing of space in the Project or any portion thereof and (d) sums paid in settlement of Claims that arise during or after the Term, in each case as a
result of Tenant’s negligent use of the Acid Neutralization Tank. This indemnification by Tenant includes costs incurred in connection with any investigation of site conditions or any clean-up, remediation, removal or restoration required by
any Governmental Authority caused by Tenant’s improper use of the Acid Neutralization Tank. 

  
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 17. Alterations. 
 17.1. Tenant shall make no alterations, additions or improvements in or to the Premises or engage in any construction, demolition, reconstruction, renovation, or other work (whether major or minor) of any
kind in, at, or serving the Premises (“Alterations”) without Landlord’s prior written approval, which approval Landlord shall not unreasonably withhold, delay or condition, other than such items that cost less than Twenty-Five
Thousand Dollars ($25,000) and do not affect (a) any structural portions of the Building, including exterior walls, roof, foundation, foundation systems (including barriers and subslab systems), or core of the Building, (b) the exterior of
the Building or (c) any Building systems, including elevator, plumbing, air conditioning, heating, electrical, security, life safety and power (“Permitted Alterations”). Tenant shall, in making any such Alterations, use only
those architects, contractors, suppliers and mechanics of which Landlord has given prior written approval, which approval shall not be unreasonably withheld, delayed or conditioned. In seeking Landlord’s approval, Tenant shall provide Landlord,
at least fourteen (14) days in advance of any proposed construction, with plans, specifications, bid proposals, certified stamped engineering drawings and calculations by Tenant’s engineer of record or architect or record, (including
connections to the Building’s structural system, modifications to the Building’s envelope, non-structural penetrations in slabs or walls, and modifications or tie-ins to life safety systems), work contracts, requests for laydown areas and
such other information concerning the nature and cost of the Alterations as Landlord may reasonably request. In no event shall Tenant use or Landlord be required to approve any architects, consultants, contractors, subcontractors or material
suppliers that Landlord reasonably believes are likely to cause labor disharmony. 
 17.2. Tenant shall not construct or permit
to be constructed partitions or other obstructions that might interfere with free access to mechanical installation or service facilities of the Building or with other tenants’ components located within the Building, or interfere with the
moving of Landlord’s equipment to or from the enclosures containing such installations or facilities. 
 17.3. Tenant shall
accomplish any work performed on the Premises or the Building in such a manner as to permit any life safety systems to remain fully operable at all times. 
 17.4. Any work performed on the Premises, the Building or the Project by Tenant or Tenant’s contractors shall be done at such times and in such manner as Landlord may from time to time reasonably
designate. Tenant covenants and agrees that all work done by Tenant or Tenant’s contractors shall be performed in full compliance with Applicable Laws. Within thirty (30) days after completion of any Alterations, Tenant shall provide
Landlord with complete “as-built” drawing print sets and electronic CADD files on disc (or files in such other current format in common use as Landlord reasonably approves or requires) showing any changes in the Premises. 

17.5. Before commencing any Alterations or Tenant Improvements, Tenant shall give Landlord at least fourteen (14) days’ prior
written notice of the proposed commencement of such work and shall, if required by Landlord, secure, at Tenant’s own cost and expense, a completion and lien indemnity bond satisfactory to Landlord for said work. 

  
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 17.6. All Alterations, attached equipment, decorations, fixtures, movable laboratory
casework and related appliances, trade fixtures, additions and improvements, subject to Section 17.8, attached to or built into the Premises, made by either of the Parties, including all floor and wall coverings, built-in cabinet work
and paneling, sinks and related plumbing fixtures, laboratory benches, exterior venting fume hoods and walk-in freezers and refrigerators, ductwork, conduits, electrical panels and circuits, shall (unless, prior to such construction or installation,
Landlord elects otherwise) become the property of Landlord upon the expiration or earlier termination of the Term, and shall remain upon and be surrendered with the Premises as a part thereof. The Premises shall at all times remain the property of
Landlord and shall be surrendered to Landlord upon the expiration or earlier termination of this Lease. All trade fixtures, equipment, Tenant Improvements, Alterations and Signage installed by or under Tenant shall be the property of Landlord.

 17.7. Tenant shall repair any damage to the Premises caused by Tenant’s removal of any property from the Premises.
During any such restoration period, Tenant shall pay Rent to Landlord as provided herein as if said space were otherwise occupied by Tenant. The provisions of this Section shall survive the expiration or earlier termination of this Lease.

 17.8. Except as to those items listed on Exhibit H attached hereto, all business and trade fixtures, machinery and
equipment, built-in furniture and cabinets, together with all additions and accessories thereto, installed in and upon the Premises shall be and remain the property of Landlord and shall not be moved by Tenant at any time during the Term. If Tenant
shall fail to remove any of its effects from the Premises prior to termination of this Lease, then Landlord may, at its option, remove the same in any manner that Landlord shall choose and store said effects without liability to Tenant for loss
thereof or damage thereto, and Tenant shall pay Landlord, upon demand, any costs and expenses incurred due to such removal and storage or Landlord may, at its sole option and without notice to Tenant, sell such property or any portion thereof at
private sale and without legal process for such price as Landlord may obtain and apply the proceeds of such sale against any (a) amounts due by Tenant to Landlord under this Lease and (b) any expenses incident to the removal, storage and
sale of said personal property. 
 17.9. Notwithstanding any other provision of this Article to the contrary, in no event shall
Tenant remove any improvement from the Premises as to which Landlord contributed payment, including the Tenant Improvements, without Landlord’s prior written consent, which consent Landlord may withhold in its sole and absolute discretion.

 17.10. Tenant shall pay to Landlord an amount equal to Landlord’s reasonable out-of-pocket costs paid to third parties
for plan review, coordination, scheduling and supervision thereof. For purposes of payment of such sum, Landlord shall submit to Tenant copies of all bills, invoices and statements covering the costs of such charges. Tenant shall reimburse Landlord
for any extra expenses incurred by Landlord by reason of faulty work done by Tenant or its contractors, or by reason of delays caused by such work, or by reason of inadequate clean-up. 

17.11. Within sixty (60) days after final completion of the Tenant Improvements (or any other Alterations performed by Tenant with
respect to the Premises), Tenant shall submit to Landlord receipts, lien waivers and other documentation reasonably acceptable to Landlord, showing the amounts expended by Tenant with respect to such Tenant Improvements (or any other Alterations
performed by Tenant with respect to the Premises). 

  
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 17.12. Tenant shall take, and shall cause its contractors to take, commercially reasonable
steps to protect the Premises during the performance of any Alterations, including covering or temporarily removing any window coverings so as to guard against dust, debris or damage. 

17.13. Tenant shall require its contractors and subcontractors performing work on the Premises to name Landlord and its affiliates and
Lenders as additional insureds on their respective insurance policies. 
 18. Repairs and Maintenance. 

18.1. Landlord shall repair and maintain the structural and exterior portions and Common Areas of the Building and the Project, including
roofing and covering materials; foundations; exterior walls; plumbing; fire sprinkler systems (if any); heating, ventilating, air conditioning systems; the Acid Neutralization Tank and associated monitoring system; elevators; and electrical systems
installed or furnished by Landlord. Tenant may provide, at Tenant’s sole cost and expense, a dumpster or compactor at the eastern loading dock of the Building for Tenant’s disposal of non-hazardous/non-controlled substances. 

18.2. Except for services of Landlord, if any, required by Section 18.1, Tenant shall at Tenant’s sole cost and expense
maintain and keep the Premises and every part thereof and the Liquid Nitrogen Tank (as defined in the Work Letter) in good condition and repair, damage thereto from ordinary wear and tear excepted. Tenant shall, upon the expiration or sooner
termination of the Term, surrender the Premises to Landlord in as good a condition as when received, ordinary wear and tear excepted; and shall, at Landlord’s request, remove all telephone and data systems, wiring and equipment from the
Premises, and repair any damage to the Premises caused thereby. Landlord shall have no obligation to alter, remodel, improve, repair, decorate or paint the Premises or any part thereof. Tenant, at its sole cost and expense, shall supply its own
janitorial and trash services for the Premises. 
 18.3. Landlord shall not be liable for any failure to make any repairs or to
perform any maintenance that is an obligation of Landlord unless such failure shall persist for an unreasonable time after Tenant provides Landlord with written notice of the need of such repairs or maintenance. Tenant waives its rights under
Applicable Laws now or hereafter in effect to make repairs at Landlord’s expense. 
 18.4. If any excavation shall be made
upon land adjacent to or under the Building, or shall be authorized to be made, Tenant shall afford to the person causing or authorized to cause such excavation, license to enter the Premises for the purpose of performing such work as said person
shall reasonably deem necessary or desirable to preserve and protect the Building from injury or damage and to support the same by proper foundations (provided that such does not materially impact Tenant’s business or operations) without
any claim for damages or liability against Landlord and without reducing or otherwise affecting Tenant’s obligations under this Lease. 

  
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 18.5. This Article relates to repairs and maintenance arising in the ordinary course of
operation of the Building and the Project. In the event of a casualty described in Article 24, Article 24 shall apply in lieu of this Article. In the event of eminent domain, Article 25 shall apply in lieu of this Article.

 18.6. Costs incurred by Landlord pursuant to this Article shall constitute Operating Expenses, unless such costs are incurred
due in whole or in part to any act, neglect, fault or omissions of Landlord or its employees, agents, contractors or invitees. Costs incurred by Landlord pursuant to this Article shall, to the extent incurred due to any act, neglect, fault or
omissions of Tenant or its employees, agents, contractors or invitees, not constitute Operating Expenses, and Tenant shall pay such costs to Landlord. 
 19. Liens. 
 19.1. Subject to the immediately succeeding sentence, Tenant
shall keep the Premises, the Building and the Project free from any liens arising out of work performed, materials furnished or obligations incurred by Tenant. Tenant further covenants and agrees that any mechanic’s lien filed against the
Premises, the Building or the Project for work claimed to have been done for, or materials claimed to have been furnished to, shall be discharged or bonded by Tenant within ten (10) days after the filing thereof, at Tenant’s sole cost and
expense. 
 19.2. Should Tenant fail to discharge or bond against any lien of the nature described in Section 19.1,
Landlord may, at Landlord’s election, pay such claim or post a bond or otherwise provide security to eliminate the lien as a claim against title, and Tenant shall immediately reimburse Landlord for the costs thereof as Additional Rent. Tenant
shall indemnify, save, defend (at Landlord’s option and with counsel reasonably acceptable to Landlord) and hold the Landlord Indemnitees harmless from and against any Claims, excluding consequential damages, arising from any such liens,
including any administrative, court or other legal proceedings related to such liens. 
 19.3. In the event that Tenant leases
or finances the acquisition of office equipment, furnishings or other personal property of a removable nature utilized by Tenant in the operation of Tenant’s business, Tenant warrants that any Uniform Commercial Code financing statement shall,
upon its face or by exhibit thereto, indicate that such financing statement is applicable only to removable personal property of Tenant located within the Premises. Landlord shall execute and deliver such reasonable documents reasonably requested by
Tenant’s lender in connection therewith. In no event shall the address of the Premises, the Building or the Project be furnished on a financing statement without qualifying language as to applicability of the lien only to removable personal
property located in an identified suite leased by Tenant. Should any holder of a financing statement record or place of record a financing statement that appears to constitute a lien against any interest of Landlord or against equipment that may be
located other than within an identified suite leased by Tenant, Tenant shall, within ten (10) days after filing such financing statement, cause (a) a copy of the Lender security agreement or other documents to which the financing statement
pertains to be furnished to Landlord to facilitate Landlord’s ability to demonstrate that the lien of such financing statement is not applicable to Landlord’s interest and (b) Tenant’s Lender to amend such financing statement and
any other documents of record to clarify that any liens imposed thereby are not applicable to any interest of Landlord in the Premises, the Building or the Project. 

  
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 20. Estoppel Certificate. Tenant shall, within ten (10) business days of receipt of written
notice from Landlord, execute, acknowledge and deliver a statement in writing substantially in the form attached to this Lease as Exhibit I, or on any other form reasonably requested by a proposed Lender or purchaser, (a) certifying that
this Lease is unmodified and in full force and effect (or, if modified, stating the nature of such modification and certifying that this Lease as so modified is in full force and effect) and the dates to which rental and other charges are paid in
advance, if any, (b) acknowledging that there are not, to Tenant’s knowledge, any uncured defaults on the part of Landlord hereunder, or specifying such defaults if any are claimed, and (c) setting forth such further information with
respect to this Lease or the Premises as may be requested thereon. Any such statement may be relied upon by any prospective purchaser or encumbrancer of all or any portion of the real property of which the Premises are a part. Tenant’s failure
to deliver such statement within such the prescribed time, following additional notice and an additional five (5) business day cure period, shall, at Landlord’s option, constitute a Default (as defined below) under this Lease. 

21. Hazardous Materials. 

21.1. Tenant shall not cause or permit any Hazardous Materials (as defined below) to be brought upon, kept or used in or about the
Premises, the Building or the Project in violation of Applicable Laws by Tenant or its employees, agents, contractors or invitees. If Tenant breaches such obligation, or if the presence of Hazardous Materials as a result of such a breach results in
contamination of the Project, any portion thereof, or any adjacent property, or if contamination of the Project, any portion thereof, or any adjacent property by Hazardous Materials otherwise occurs during the Term or any extension or renewal hereof
or holding over hereunder, then Tenant shall indemnify, save, defend (at Landlord’s option and with counsel reasonably acceptable to Landlord) and hold the Landlord Indemnitees harmless from and against any and all Claims, including
(a) diminution in value of the Project or any portion thereof, (b) damages for the loss or restriction on use of rentable or usable space or of any amenity of the Project, (c) damages arising from any adverse impact on marketing of
space in the Project or any portion thereof and (d) sums paid in settlement of Claims that arise during or after the Term as a result of such breach or contamination. This indemnification by Tenant includes costs incurred in connection with any
investigation of site conditions or any clean-up, remedial, removal or restoration work required by any Governmental Authority because of Hazardous Materials present in the air, soil or groundwater above, on or under or about the Project. Without
limiting the foregoing, if the presence of any Hazardous Materials in, on, under or about the Project, any portion thereof or any adjacent property caused or permitted by Tenant results in any contamination of the Project, any portion thereof or any
adjacent property, then Tenant shall promptly take all actions at its sole cost and expense as are necessary to return the Project, any portion thereof or any adjacent property to its respective condition existing prior to the time of such
contamination; provided that Landlord’s written approval of such action shall first be obtained, which approval Landlord shall not unreasonably withhold; and provided, further, that it shall be reasonable for Landlord to withhold
its consent if such actions could have a material adverse long-term or short-term effect on the Project, any portion thereof or any adjacent property. 

  
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 21.2. Landlord acknowledges that it is not the intent of this Article to prohibit Tenant
from operating its business for the Permitted Use. Tenant may operate its business according to the custom of Tenant’s industry so long as the use or presence of Hazardous Materials is strictly and properly monitored in accordance with
Applicable Laws. As a material inducement to Landlord to allow Tenant to use Hazardous Materials in connection with its business, Tenant agrees to deliver to Landlord prior to the Term Commencement Date a list identifying each type of Hazardous
Material to be present at the Project and setting forth any and all governmental approvals or permits required in connection with the presence of such Hazardous Material at the Project (the “Hazardous Materials List”). Tenant shall
deliver to Landlord an updated Hazardous Materials List on or prior to each annual anniversary of the Term Commencement Date and shall also deliver an updated Hazardous Materials List before any new Hazardous Materials are brought to the Project.
Tenant shall deliver to Landlord true and correct copies of the following documents (hereinafter referred to as the “Documents”) relating to the handling, storage, disposal and emission of Hazardous Materials prior to the Term
Commencement Date or, if unavailable at that time, concurrently with the receipt from or submission to any Governmental Authority: permits; approvals; reports and correspondence; storage and management plans; notices of violations of Applicable
Laws; plans relating to the installation of any storage tanks to be installed in, on, under or about the Project (provided that installation of storage tanks shall only be permitted after Landlord has given Tenant its written consent to do
so, which consent Landlord may withhold in its sole and absolute discretion); and all closure plans or any other documents required by any and all Governmental Authorities for any storage tanks installed in, on, under or about the Project for the
closure of any such storage tanks, including the Liquid Nitrogen Tank (as defined in the Work Letter). Tenant shall not be required, however, to provide Landlord with any portion of the Documents containing information of a proprietary nature, which
Documents, in and of themselves, do not contain a reference to any Hazardous Materials or activities related to Hazardous Materials. 
 21.3. Notwithstanding the provisions of Sections 21.1 21.2 or 21.9, if (a) Tenant or any proposed transferee, assignee or sublessee of Tenant has been required by any prior
landlord, Lender or Governmental Authority to take material remedial action in connection with Hazardous Materials contaminating a property if the contamination resulted from such party’s action or omission or use of the property in question or
(b) Tenant or any proposed transferee, assignee or sublessee is subject to a material enforcement order issued by any Governmental Authority in connection with the use, disposal or storage of Hazardous Materials, then Landlord shall have the
right to terminate this Lease in Landlord’s sole and absolute discretion (with respect to any such matter involving Tenant), and it shall not be unreasonable for Landlord to withhold its consent to any proposed transfer, assignment or
subletting (with respect to any such matter involving a proposed transferee, assignee or sublessee). 
 21.4. At any time, and
from time to time, prior to the expiration of the Term, Landlord shall have the right to conduct appropriate tests of the Project or any portion thereof to demonstrate that Hazardous Materials are present or that contamination has occurred due to
Tenant or Tenant’s employees, agents, contractors or invitees. Tenant shall pay all reasonable costs of such tests if such tests reveal that Hazardous Materials exist in the Premises or have been released by Tenant at the Project in violation
of this Lease. 

  
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 21.5. If underground or other storage tanks storing Hazardous Materials are hereafter placed
on the Premises by Tenant (including the Liquid Nitrogen Tank (as defined in the Work Letter)), Tenant shall monitor the storage tanks, maintain appropriate records, implement reporting procedures, properly close any underground storage tanks, and
take or cause to be taken all other steps necessary or required under the Applicable Laws. 
 21.6. Tenant shall promptly report
to Landlord any actual or suspected presence of mold or water intrusion at the Premises. 
 21.7. Tenant’s obligations
under this Article shall survive the expiration or earlier termination of the Lease. During any period of time needed by Tenant or Landlord after the termination of this Lease to complete the removal from the Premises of any such Hazardous
Materials, Tenant shall be deemed a holdover tenant and subject to the provisions of Article 27 below. 
 21.8. As used
herein, the term “Hazardous Material” means any hazardous or toxic substance, material or waste that is or becomes regulated by any Governmental Authority. 

21.9. Notwithstanding anything to the contrary in this Lease, Landlord shall have sole control over the equitable
allocation of fire control areas (as defined in the Uniform Building Code as adopted by the city or municipality(ies) in which the Project is located (the “UBC”)) within the Project for the storage of Hazardous Materials; provided,
however, that Tenant shall be entitled to use of two (2) fire control areas on the first (1st) floor of the Building and one (1) fire control area on the second
(2nd) floor of the Building. Notwithstanding anything
to the contrary in this Lease, the quantity of Hazardous Materials allowed by this Section 21.9 is specific to Tenant and shall not run with the Lease in the event of a Transfer, other than an Exempt Transfer (as each such term as
defined in Article 29). In the event of a Transfer, if the use of Hazardous Materials by such new tenant (“New Tenant”) is such that New Tenant utilizes fire control areas in the Project in excess of New Tenant’s Pro
Rata Share of the Project, then New Tenant shall, at its sole cost and expense and upon Landlord’s written request, establish and maintain a separate area of the Premises classified by the UBC as an “H” occupancy area for the use and
storage of Hazardous Materials, or take such other action as is necessary to ensure that its share of the fire control areas of the Project is not greater than New Tenant’s Pro Rata Share of the Project. 

21.10. Landlord shall indemnify, save, defend (at Tenant’s option and with counsel reasonably acceptable to Tenant) and hold the
Tenant Indemnitees (as defined below) harmless from and against any and all Claims arising in connection with the presence, use, generation, storage, release, threatened release, disposal or transport of Hazardous Materials at the Project, the
Building or the Premises prior to the Term Commencement Date of this Lease, including costs of any required or necessary repair, clean-up or detoxification and preparation of any closure or other required plans. This agreement to indemnify and hold
harmless shall survive the expiration or termination of this Lease. 
 22. Odors, Exhaust and Noise. Tenant acknowledges that Landlord
would not enter into this Lease with Tenant unless Tenant assured Landlord that under no circumstances will any other occupants of the Building or the Project (including persons legally present in any outdoor areas

  
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of the Project) be subjected to odors or fumes (whether or not noxious), and that the Building and the Project will not be damaged by any exhaust, in each case from Tenant’s operations,
including in Tenant’s vivarium. Landlord and Tenant therefore agree as follows: 
 22.1. Tenant shall not cause or permit
(or conduct any activities that would cause) any release of any odors or fumes of any kind from the Premises. 
 22.2. If the
Building has a ventilation system that, in Landlord’s judgment, is adequate, suitable, and appropriate to vent the Premises in a manner that does not release odors affecting any indoor or outdoor part of the Project, Tenant shall vent the
Premises through such system. If Landlord at any time determines that any existing ventilation system is inadequate, or if no ventilation system exists, Tenant shall in compliance with Applicable Laws vent all fumes and odors from the Premises (and
remove odors from Tenant’s exhaust stream) as Landlord requires. The placement and configuration of all ventilation exhaust pipes, louvers and other equipment shall be subject to Landlord’s approval. Tenant acknowledges Landlord’s
legitimate desire to maintain the Project (indoor and outdoor areas) in an odor-free manner, and Landlord may require Tenant to abate and remove all odors in a manner that goes beyond the requirements of Applicable Laws. 

22.3. Tenant shall, at Tenant’s sole cost and expense, provide odor eliminators and other devices (such as filters, air cleaners,
scrubbers and whatever other equipment may in Landlord’s judgment be necessary or appropriate from time to time) to completely remove, eliminate and abate any odors, fumes or other substances in Tenant’s exhaust stream that, in
Landlord’s judgment, emanate from Tenant’s Premises. Any work Tenant performs under this Section shall constitute Alterations. 
 22.4. Tenant’s responsibility to remove, eliminate and abate odors, fumes and exhaust shall continue throughout the Term. Landlord’s approval of the Tenant Improvements shall not preclude
Landlord from requiring additional measures to eliminate odors, fumes and other adverse impacts of Tenant’s exhaust stream (as Landlord may designate in Landlord’s discretion). Tenant shall install additional equipment as Landlord requires
from time to time under the preceding sentence. Such installations shall constitute Alterations. 
 22.5. If Tenant fails to
install satisfactory odor control equipment within ten (10) business days after Landlord’s demand made at any time, then Landlord may, without limiting Landlord’s other rights and remedies, require Tenant to cease and suspend any
operations in the Premises that, in Landlord’s determination, cause odors, fumes or exhaust. For example, if Landlord determines that Tenant’s production of a certain type of product causes odors, fumes or exhaust, and Tenant does not
install satisfactory odor control equipment within ten (10) business days after Landlord’s request, then Landlord may require Tenant to stop producing such type of product in the Premises unless and until Tenant has installed odor control
equipment satisfactory to Landlord. 
 22.6. Tenant acknowledges that Landlord would not enter into this Lease with Tenant
unless Tenant assured Landlord that under no circumstances will any other occupants of the Project (including persons legally present in any outdoor areas of the Project) be subjected to any noise from Tenant’s operations affecting the use of
the Project by any other tenant. Landlord and Tenant therefore agree as follows: 
 (a) Tenant shall not cause or permit (or
conduct any activities that would cause or permit) any noise affecting the use of the Project by any other tenant to be emitted from the Premises; 

  
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 (b) If Landlord at any time determines that any existing noise control system is inadequate,
or if no noise control system exists, Tenant shall install (in compliance with Applicable Laws) such noise control system as Landlord requires. The placement and configuration of the noise control system shall be subject to Landlord’s approval.
Tenant acknowledges Landlord’s legitimate desire to maintain the Project (including indoor and outdoor areas) in a quiet and peaceful manner, and Landlord may require Tenant to cease all noises in a manner that goes beyond the requirements of
Applicable Laws; 
 (c) Tenant shall, at Tenant’s sole cost and expense, install a noise control system (such as
insulation, wall coverings and whatever other equipment may in Landlord’s judgment be necessary or appropriate from time to time) to completely remove, eliminate and abate any noise that emanates from the Premises. Any work Tenant performs
under this Section shall constitute Alterations; 
 (d) Landlord’s construction of Landlord’s Work shall not preclude
Landlord from requiring additional measures to eliminate sounds from the Premises (as Landlord may designate in Landlord’s discretion); and 
 (e) If Tenant fails to install the required noise control system or equipment within ten (10) business days after Landlord’s request, then Landlord may, without limiting Landlord’s other
rights and remedies, require Tenant to cease and suspend any operations in the Premises that, in Landlord’s reasonable determination, cause noise in violation of this Article. 
 23. Insurance; Waiver of Subrogation. 
 23.1. Landlord shall maintain
insurance for the Building and the Project in amounts equal to full replacement cost (exclusive of the costs of excavation, foundations and footings, and without reference to depreciation taken by Landlord upon its books or tax returns) or such
lesser coverage as Landlord may elect, provided that such coverage shall not be less than ninety percent (90%) of such full replacement cost or the amount of such insurance Landlord’s Lender, if any, requires Landlord to maintain,
providing protection against any peril generally included within the classification “Fire and Extended Coverage,” together with insurance against sprinkler damage (if applicable), vandalism and malicious mischief. Landlord, subject to
availability thereof, shall further insure, if Landlord deems it appropriate, coverage against flood, environmental hazard, earthquake, loss or failure of building equipment, rental loss during the period of repairs or rebuilding, workmen’s
compensation insurance and fidelity bonds for employees employed to perform services. Notwithstanding the foregoing, Landlord may, but shall not be deemed required to, provide insurance for any improvements installed by Tenant or that are in
addition to the standard improvements customarily furnished by Landlord, without regard to whether or not such are made a part of or are affixed to the Building. 

  
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 23.2. In addition, Landlord shall carry public liability insurance with a single limit of
not less than One Million Dollars ($1,000,000) for death or bodily injury, or property damage with respect to the Project. 

23.3. Tenant shall, at its own cost and expense, procure and maintain in effect, beginning on the Term Commencement Date or the date of
occupancy, whichever occurs first, and continuing throughout the Term (and occupancy by Tenant, if any, after termination of this Lease) comprehensive public liability insurance with limits of not less than Two Million Dollars ($2,000,000) per
occurrence for death or bodily injury and for property damage with respect to the Premises (including $100,000 fire legal liability (each loss)). 
 23.4. The insurance required to be purchased and maintained by Tenant pursuant to this Lease shall name Landlord, BioMed Realty, L.P., BioMed Realty Trust, Inc. and their respective officers, directors,
employees, agents, general partners, members, subsidiaries, affiliates and Lenders (“Landlord Parties”) as additional insureds. Said insurance shall be with companies authorized to do business in the state in which the Project is
located and having a rating of not less than policyholder rating of A and financial category rating of at least Class XII in “Best’s Insurance Guide.” Tenant shall obtain for Landlord from the insurance companies or cause the
insurance companies to furnish certificates of coverage to Landlord. No such policy shall be cancelable or subject to reduction of coverage or other modification or cancellation except after thirty (30) days’ prior written notice to
Landlord from the insurer (except in the event of non-payment of premium, in which case ten (10) days written notice shall be given). All such policies shall be written as primary policies, not contributing with and not in excess of the
coverage that Landlord may carry. Tenant’s policy may be a “blanket policy” that specifically provides that the amount of insurance shall not be prejudiced by other losses covered by the policy. Tenant shall, at least twenty
(20) days prior to the expiration of such policies, furnish Landlord with renewals or binders. Tenant agrees that if Tenant does not take out and maintain such insurance, Landlord may (but shall not be required to) procure said insurance on
Tenant’s behalf and at its cost to be paid by Tenant as Additional Rent. 
 23.5. Tenant assumes the risk of damage to any
fixtures, goods, inventory, merchandise, equipment and leasehold improvements, and Landlord shall not be liable for injury to Tenant’s business or any loss of income therefrom, relative to such damage, all as more particularly set forth within
this Lease. Tenant shall, at Tenant’s sole cost and expense, carry such insurance as Tenant desires for Tenant’s protection with respect to personal property of Tenant or business interruption. 

23.6. In each instance where insurance is to name Landlord Parties as additional insureds, Tenant shall, upon Landlord’s written
request, also designate and furnish certificates evidencing such Landlord Parties as additional insureds to (a) any Lender of Landlord holding a security interest in the Building, the Property or the Project, (b) the landlord under any
lease whereunder Landlord is a tenant of the Property if the interest of Landlord is or shall become that of a tenant under a ground lease rather than that of a fee owner and (c) any management company retained by Landlord to manage the
Project. 
 23.7. Landlord and Tenant each hereby waive any and all rights of recovery against the other or against the
officers, directors, employees, agents, general partners, members, 

  
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subsidiaries, affiliates and Lenders of the other on account of loss or damage occasioned by such waiving party or its property or the property of others under such waiving party’s control,
in each case to the extent that such loss or damage is insured against under any fire and extended coverage insurance policy that either Landlord or Tenant may have in force at the time of such loss or damage. Such waivers shall continue so long as
their respective insurers so permit. Any termination of such a waiver shall be by written notice to the other party, containing a description of the circumstances hereinafter set forth in this Section. Landlord and Tenant, upon obtaining the
policies of insurance required or permitted under this Lease, shall give notice to the insurance carrier or carriers that the foregoing mutual waiver of subrogation is contained in this Lease. If such policies shall not be obtainable with such
waiver or shall be so obtainable only at a premium over that chargeable without such waiver, then the party seeking such policy shall notify the other of such conditions, and the party so notified shall have ten (10) days thereafter to either
(a) procure such insurance with companies reasonably satisfactory to the other party or (b) agree to pay such additional premium (in Tenant’s case, in the proportion that the area of the Premises bears to the insured area). If the
parties do not accomplish either (a) or (b), then this Section shall have no effect during such time as such policies shall not be obtainable or the party in whose favor a waiver of subrogation is desired refuses to pay the additional premium.
If such policies shall at any time be unobtainable, but shall be subsequently obtainable, then neither party shall be subsequently liable for a failure to obtain such insurance until a reasonable time after notification thereof by the other party.
If the release of either Landlord or Tenant, as set forth in the first sentence of this Section, shall contravene Applicable Laws, then the liability of the party in question shall be deemed not released but shall be secondary to the other
party’s insurer. 
 23.8. Landlord may require insurance policy limits required under this Lease to be raised to conform
with reasonable requirements of Landlord’s Lender. 
 23.9. Any costs incurred by Landlord pursuant to this Article shall
constitute a portion of Operating Expenses. 
 24. Damage or Destruction. 

24.1. In the event of a partial destruction of (a) the Premises or (b) Common Areas of the Building or the Project ((a) and
(b) together, the “Affected Areas”) by fire or other perils covered by extended coverage insurance not exceeding twenty-five percent (25%) of the full insurable value thereof, and provided that (x) the damage
thereto is such that the Affected Areas may be repaired, reconstructed or restored within a period of six (6) months from the date of the happening of such casualty, (y) Landlord shall receive insurance proceeds sufficient to cover the
cost of such repairs (except for any deductible amount provided by Landlord’s policy, which deductible amount, if paid by Landlord, shall constitute an Operating Expense) and (z) such casualty was not intentionally caused by Tenant or its
employees, agents or contractors, then Landlord shall commence and proceed diligently with the work of repair, reconstruction and restoration of the Affected Areas and this Lease shall continue in full force and effect. 

24.2. In the event of any damage to or destruction of the Building or the Project other than as described in Section 24.1,
Landlord may elect to repair, reconstruct and restore the Building or the Project, as applicable, in which case this Lease shall continue in full force and 

  
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effect. If Landlord elects not to repair the Building or the Project, as applicable, then this Lease shall terminate as of the date of such damage or destruction, except for those provisions
that, by their express terms, survive the expiration or earlier termination thereof. 
 24.3. Landlord shall give written notice
to Tenant within sixty (60) days following the date of damage or destruction of its election not to repair, reconstruct or restore the Building or the Project, as applicable. If Landlord elects not to terminate this Lease pursuant to
Section 24.2 and (a) there are twelve (12) or fewer months remaining in the Term or (b) Landlord does not in good faith believe that the repairs, reconstruction and restoration will be completed within twelve
(12) months after the date of the damage or destruction, then Tenant may terminate this Lease as of the date of the damage or destruction, except for those provisions that, by their express terms, survive the expiration or earlier termination
thereof. 
 24.4. Upon any termination of this Lease under any of the provisions of this Article, the parties shall be released
thereby without further obligation to the other from the date possession of the Premises is surrendered to Landlord, except with regard to (a) items occurring prior to the damage or destruction and (b) provisions of this Lease that, by
their express terms, survive the expiration or earlier termination hereof. 
 24.5. In the event of repair, reconstruction and
restoration as provided in this Article, all Rent to be paid by Tenant under this Lease shall be abated proportionately based on the extent to which Tenant’s use of the Premises is impaired during the period of such repair, reconstruction or
restoration, unless Landlord provides Tenant with other space during the period of repair that, in Tenant’s reasonable opinion, is suitable for the temporary conduct of Tenant’s business; provided, however, that the amount of such
abatement shall be reduced by the proceeds of business interruption or loss of rental income insurance actually received by Tenant with respect to the Premises. 
 24.6. Notwithstanding anything to the contrary contained in this Article, should Landlord be delayed or prevented from completing the repair, reconstruction or restoration of the damage or destruction to
the Premises after the occurrence of such damage or destruction by Force Majeure, then the time for Landlord to commence or complete repairs shall be extended on a day-for-day basis; provided, however, that, at Landlord’s election,
Landlord shall be relieved of its obligation to make such repair, reconstruction or restoration, in which case this Lease shall terminate as of the date of the damage or destruction, except for those provisions that, by their express terms, survive
the expiration or earlier termination thereof. 
 24.7. If Landlord is obligated to or elects to repair, reconstruct or restore
as herein provided, then Landlord shall be obligated to make such repair, reconstruction or restoration only with regard to (a) those portions of the Premises that were originally provided at Landlord’s expense and (b) the Common Area
portion of the Affected Areas. The repair, reconstruction or restoration of improvements not originally provided by Landlord or at Landlord’s expense shall be the obligation of Tenant. In the event Tenant has elected to upgrade certain
improvements from the Building Standard, Landlord shall, upon the need for replacement due to an insured loss, provide only the Building Standard, unless Tenant again elects to upgrade such improvements and pay any incremental costs related thereto,
except to the extent that excess insurance proceeds, if received, are adequate to provide such upgrades, in addition to providing for basic repair, reconstruction and restoration of the Premises, the Building and the Project. 

  
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 24.8. Notwithstanding anything to the contrary contained in this Article, Landlord shall not
have any obligation whatsoever to repair, reconstruct or restore the Premises if the damage resulting from any casualty covered under this Article occurs during the last twenty-four (24) months of the Term or any extension hereof, or to the
extent that insurance proceeds are not available therefor. 
 24.9. Landlord’s obligation, should it elect or be obligated
to repair or rebuild, shall be limited to the Affected Areas. Tenant shall, at its expense, replace or fully repair all of Tenant’s personal property and any Alterations installed by Tenant existing at the time of such damage or destruction. If
Affected Areas are to be repaired in accordance with the foregoing, Landlord shall make available to Tenant any portion of insurance proceeds it receives that are allocable to the Alterations constructed by Tenant pursuant to this Lease;
provided Tenant is not then in default under this Lease, and subject to the requirements of any Lender of Landlord. 
 25. Eminent
Domain. 
 25.1. In the event (a) the whole of all Affected Areas or (b) such part thereof as shall substantially
interfere with Tenant’s use and occupancy of the Premises for the Permitted Use shall be taken for any public or quasi-public purpose by any lawful power or authority by exercise of the right of appropriation, condemnation or eminent domain, or
sold to prevent such taking, Tenant or Landlord may terminate this Lease effective as of the date possession is required to be surrendered to said authority, except with regard to (y) items occurring prior to the damage or destruction and
(z) provisions of this Lease that, by their express terms, survive the expiration or earlier termination hereof. 
 25.2.
In the event of a partial taking of (a) the Building or the Project or (b) drives, walkways or parking areas serving the Building or the Project for any public or quasi-public purpose by any lawful power or authority by exercise of right
of appropriation, condemnation, or eminent domain, or sold to prevent such taking, then, without regard to whether any portion of the Premises occupied by Tenant was so taken, Landlord may elect to terminate this Lease (except with regard to
(a) items occurring prior to the damage or destruction and (b) provisions of this Lease that, by their express terms, survive the expiration or earlier termination hereof) as of such taking if such taking is, in Landlord’s sole
opinion, of a material nature such as to make it uneconomical to continue use of the unappropriated portion for purposes of renting office or laboratory space. 
 25.3. Tenant shall be entitled to any award that is specifically awarded as compensation for (a) the taking of Tenant’s personal property that was installed at Tenant’s expense and
(b) the costs of Tenant moving to a new location. Except as set forth in the previous sentence, any award for such taking shall be the property of Landlord. 
 25.4. If, upon any taking of the nature described in this Article, this Lease continues in effect, then Landlord shall promptly proceed to restore the Affected Areas to substantially their same condition
prior to such partial taking. To the extent such restoration is infeasible, as determined by Landlord in its sole and absolute discretion, the Rent shall be decreased proportionately to reflect the loss of any portion of the Premises no longer
available to Tenant. 

  
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 26. Surrender. 
 26.1. At least ten (10) days prior to Tenant’s surrender of possession of any part of the Premises, Tenant shall provide Landlord with (a) a facility decommissioning and Hazardous Materials
closure plan for the Premises (“Exit Survey”) prepared by an independent third party reasonably acceptable to Landlord, and (b) written evidence of all appropriate governmental releases obtained by Tenant in accordance with
Applicable Laws, including laws pertaining to the surrender of the Premises. In addition, Tenant agrees to remain responsible after the surrender of the Premises for the remediation of any recognized environmental conditions set forth in the Exit
Survey and compliance with any recommendations set forth in the Exit Survey. Tenant’s obligations under this Section shall survive the expiration or earlier termination of the Lease. 

26.2. No surrender of possession of any part of the Premises shall release Tenant from any of its obligations hereunder, unless such
surrender is accepted in writing by Landlord. 
 26.3. The voluntary or other surrender of this Lease by Tenant shall not effect
a merger with Landlord’s fee title or leasehold interest in the Premises, the Building, the Property or the Project, unless Landlord consents in writing, and shall, at Landlord’s option, operate as an assignment to Landlord of any or all
subleases. 
 26.4. The voluntary or other surrender of any ground or other underlying lease that now exists or may hereafter be
executed affecting the Building or the Project, or a mutual cancellation thereof or of Landlord’s interest therein by Landlord and its lessor shall not effect a merger with Landlord’s fee title or leasehold interest in the Premises, the
Building or the Property and shall, at the option of the successor to Landlord’s interest in the Building or the Project, as applicable, operate as an assignment of this Lease. 
 27. Holding Over. 
 27.1. If, with Landlord’s prior written consent,
Tenant holds possession of all or any part of the Premises after the Term, Tenant shall become a tenant from month to month after the expiration or earlier termination of the Term, and in such case Tenant shall continue to pay (a) Base Rent in
accordance with Article 7, as adjusted in accordance with Article 8, and (b) any amounts for which Tenant would otherwise be liable under this Lease if the Lease were still in effect, including payments for Tenant’s Share of
Operating Expenses. Any such month-to-month tenancy shall be subject to every other term, covenant and agreement contained herein. 
 27.2. Notwithstanding the foregoing, if Tenant remains in possession of the Premises after the expiration or earlier termination of the Term without Landlord’s prior written consent, (a) Tenant
shall become a tenant at sufferance subject to the terms and conditions of this Lease, except that the monthly rent shall be equal to one hundred fifty percent (150%) of the Rent in effect during the last thirty (30) days of the Term, and
(b) Tenant shall be liable to Landlord for any and all damages suffered by Landlord as a result of such holdover, including any lost rent or consequential, special and indirect damages. 

  
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 27.3. Acceptance by Landlord of Rent after the expiration or earlier termination of the Term
shall not result in an extension, renewal or reinstatement of this Lease. 
 27.4. The foregoing provisions of this Article are
in addition to and do not affect Landlord’s right of reentry or any other rights of Landlord hereunder or as otherwise provided by Applicable Laws. 
 28. Indemnification and Exculpation. 
 28.1. Subject to
Section 23.7, Tenant agrees to indemnify, save, defend (at Landlord’s option and with counsel reasonably acceptable to Landlord) and hold the Landlord Indemnitees harmless from and against any and all Claims, excluding consequential
damages (unless otherwise specified in this Lease), arising from injury or death to any person or damage to any property occurring within or about the Premises, the Building, the Property or the Project arising directly or indirectly out of
Tenant’s or Tenant’s employees’, agents’, contractors’ or invitees’ use or occupancy of the Premises or a breach or default by Tenant in the performance of any of its obligations hereunder, except to the extent caused
by Landlord’s or Landlord Indemnitees’ negligence or willful misconduct. 
 28.2. Subject to Sections 23.7,
28.3 and 31.12 and any subrogation provisions contained in the Work Letter, Landlord agrees to indemnify, save, defend (at Tenant’s option and with counsel reasonably acceptable to Tenant) and hold Tenant and its affiliates,
members, employees, agents and contractors (the “Tenant Indemnitees”) harmless from and against any and all Claims, excluding consequential damages, arising from injury or death to any person or damage to any property occurring
within or about the Premises, the Building, the Property or the Project arising directly or indirectly out of Landlord’s or Landlord’s employees’, agents’, contractors’ or invitees’ gross negligence or willful
misconduct, except to the extent caused by Tenant’s or Tenant Indemnitees’ negligence or willful misconduct. 
 28.3.
Notwithstanding any provision of Section 28.1 to the contrary, Landlord shall not be liable to Tenant for, and Tenant assumes all risk of, damage to personal property or scientific research, including loss of records kept by Tenant
within the Premises and damage or losses caused by fire, electrical malfunction, gas explosion or water damage of any type (including broken water lines, malfunctioning fire sprinkler systems, roof leaks or stoppages of lines), unless any such loss
is due to Landlord’s willful disregard of written notice by Tenant of need for a repair that Landlord is responsible to make for an unreasonable period of time. Tenant further waives any claim for injury to Tenant’s business or loss of
income relating to any such damage or destruction of personal property as described in this Section. 
 28.4. Landlord shall not
be liable for any damages arising from any act, omission or neglect of any other tenant in the Building or the Project, or of any other third party. 
 28.5. Tenant acknowledges that security devices and services, if any, while intended to deter crime, may not in given instances prevent theft or other criminal acts. Landlord shall not be liable for
injuries or losses caused by criminal acts of third parties, and Tenant assumes the risk that any security device or service may malfunction or otherwise be circumvented by a criminal. If Tenant desires protection against such criminal acts, then
Tenant shall, at Tenant’s sole cost and expense, obtain appropriate insurance coverage. 
 28.6. The provisions of this
Article shall survive the expiration or earlier termination of this Lease. 

  
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 29. Assignment or Subletting. 

29.1. Except as hereinafter expressly permitted, Tenant shall not, either voluntarily or by operation of Applicable Laws, directly or
indirectly sell, hypothecate, assign, pledge, encumber or otherwise transfer this Lease, or sublet the Premises (each, a “Transfer”), without Landlord’s prior written consent, which shall not be unreasonably withheld,
conditioned or delayed. Notwithstanding the foregoing, Tenant shall have the right to Transfer without Landlord’s prior written consent the Premises or any part thereof to (a) any person that as of the date of determination and at all
times thereafter directly, or indirectly through one or more intermediaries, controls, is controlled by, or is under common control with Tenant (“Tenant’s Affiliate”), or (b) any entity that succeeds to Tenant’s
interest in this Lease by reason of merger, spin-off, acquisition (whereby the spin-off or acquisition consists of all or substantially all of Tenant’s stock or assets) or consolidation (“Tenant’s Successor”),
provided that (m) Tenant shall notify Landlord in writing at least ten (10) days prior to the effectiveness of such Transfer to Tenant’s Affiliate or Tenant’s Successor (each an “Exempt Transfer”),
(n) if Tenant ceases to exist as an ongoing business as a result of such Exempt Transfer, Tenant’s Successor must have a net worth equal to or greater than the net worth of Tenant as of the date immediately preceding such Transfer and
(o) Tenant shall otherwise comply with the requirements of this Lease regarding such Transfer. For purposes of an Exempt Transfer to Tenant’s Affiliate, “control” requires both (y) owning (directly or indirectly) more than
fifty percent (50%) of the stock or other equity interests of another person and (z) possessing, directly or indirectly, the power to direct or cause the direction of the management and policies of such person. In no event shall Tenant
perform a Transfer (other than an Exempt Transfer) to or with an entity that is a tenant at the Project or that is in discussions or negotiations with Landlord or an affiliate of Landlord to lease premises at the Project (unless comparable space in
the Building is not then available for lease from Landlord). 
 29.2. In the event Tenant desires to effect a Transfer, then,
(a) in the case of Transfers other than Exempt Transfers, at least thirty (30) but not more than ninety (90) days prior to the date when Tenant desires the assignment or sublease to be effective or (b) in the case of Exempt
Transfers, at least ten (10) days prior to the date when Tenant desires the assignment or sublease to be effective (the “Transfer Date”), Tenant shall provide written notice to Landlord (the “Transfer Notice”)
containing information (including references) concerning the character of the proposed transferee, assignee or sublessee; the Transfer Date; any ownership or commercial relationship between Tenant and the proposed transferee, assignee or sublessee;
in the case of Exempt Transfers, the reason such Transfer is an Exempt Transfer; and in the case of Transfers other than Exempt Transfers, the consideration and all other material terms and conditions of the proposed Transfer; all in such detail as
Landlord shall reasonably require. 
 29.3. Landlord, in determining whether consent should be given to a proposed Transfer, may
give consideration to (a) the financial strength of such transferee, assignee or sublessee 

  
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(notwithstanding Tenant remaining liable for Tenant’s performance), (b) any change in use that such transferee, assignee or sublessee proposes to make in the use of the Premises and
(c) Landlord’s desire to exercise its rights under Section 29.8 to cancel this Lease with respect to the portion of the Premises being sublet. In no event shall Landlord be deemed to be unreasonable for declining to consent to
a Transfer to a transferee, assignee or sublessee of poor reputation, lacking financial qualifications or seeking a change in the Permitted Use, or jeopardizing directly or indirectly the status of Landlord or any of Landlord’s affiliates as a
Real Estate Investment Trust under the Internal Revenue Code of 1986 (as the same may be amended from time to time, the “Revenue Code”). Notwithstanding anything contained in this Lease to the contrary, (w) no Transfer shall be
consummated on any basis such that the rental or other amounts to be paid by the occupant, assignee, manager or other transferee thereunder would be based, in whole or in part, on the income or profits derived by the business activities of such
occupant, assignee, manager or other transferee; (x) Tenant shall not furnish or render any services to an occupant, assignee, manager or other transferee with respect to whom transfer consideration is required to be paid, or manage or operate
the Premises or any capital additions so transferred, with respect to which transfer consideration is being paid; (y) Tenant shall not consummate a Transfer with any person in which Landlord owns an interest, directly or indirectly (by applying
constructive ownership rules set forth in Section 856(d)(5) of the Revenue Code); and (z) Tenant shall not consummate a Transfer with any person or in any manner that could cause any portion of the amounts received by Landlord pursuant to
this Lease or any sublease, license or other arrangement for the right to use, occupy or possess any portion of the Premises to fail to qualify as “rents from real property” within the meaning of Section 856(d) of the Revenue Code, or
any similar or successor provision thereto or which could cause any other income of Landlord to fail to qualify as income described in Section 856(c)(2) of the Revenue Code. 

29.4. As conditions precedent to Tenant subleasing the Premises or to Landlord considering a request by Tenant to Tenant’s transfer
of rights or sharing of the Premises, Landlord may require any or all of the following; provided that only (a), (c), (e), (g), (h), (i), (j), (k), (l) and (m) below shall apply to Exempt Transfers: 

(a) Tenant shall remain fully liable under this Lease during the unexpired Term; 

(b) Tenant shall provide Landlord with evidence reasonably satisfactory to Landlord that the value of Landlord’s interest under
this Lease shall not be diminished or reduced by the proposed Transfer. Such evidence shall include evidence respecting the relevant business experience and financial responsibility and status of the proposed transferee, assignee or sublessee;

 (c) Tenant shall reimburse Landlord for Landlord’s actual costs and expenses, including reasonable attorneys’
fees, charges and disbursements incurred in connection with the review, processing and documentation of such request, not to exceed Two Thousand Five Hundred Dollars ($2,500); 
 (d) If Tenant’s transfer of rights or sharing of the Premises provides for the receipt by, on behalf of or on account of Tenant of any consideration of any kind whatsoever (including a premium
rental for a sublease or lump sum payment for an assignment, but 

  
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excluding Tenant’s reasonable costs in marketing and subleasing the Premises) in excess of the rental and other charges due to Landlord under this Lease, Tenant shall pay fifty percent
(50%) of all of such excess to Landlord, after making deductions for any reasonable marketing expenses, tenant improvement funds expended by Tenant, alterations, cash concessions, brokerage commissions, attorneys’ fees, architectural and
engineering fees, and free rent actually paid by Tenant. If said consideration consists of cash paid to Tenant, payment to Landlord shall be made upon receipt by Tenant of such cash payment; 

(e) The proposed transferee, assignee or sublessee shall agree that, in the event Landlord gives such proposed transferee, assignee or
sublessee notice that Tenant is in default under this Lease, such proposed transferee, assignee or sublessee shall thereafter make all payments otherwise due Tenant directly to Landlord, which payments shall be received by Landlord without any
liability being incurred by Landlord, except to credit such payment against those due by Tenant under this Lease, and any such proposed transferee, assignee or sublessee shall agree to attorn to Landlord or its successors and assigns should this
Lease be terminated for any reason; provided, however, that in no event shall Landlord or its Lenders, successors or assigns be obligated to accept such attornment; 
 (f) Landlord’s consent to any such Transfer shall be effected on Landlord’s forms; 
 (g) Tenant shall not then be in default hereunder in any respect; 
 (h) Such
proposed transferee, assignee or sublessee’s use of the Premises shall be the same as the Permitted Use; 
 (i) Landlord
shall not be bound by any provision of any agreement pertaining to the Transfer, except for Landlord’s written consent to the same; 
 (j) Tenant shall pay all transfer and other taxes (including interest and penalties) assessed or payable for any Transfer; 
 (k) Any Exempt Transfer or Landlord’s consent (or waiver of its rights) for any other Transfer shall not waive Landlord’s right to consent to any later Transfer; 

(l) Tenant shall deliver to Landlord one executed copy of any and all written instruments evidencing or relating to the Transfer; and

 (m) A list of Hazardous Materials (as defined in Section 21.7), certified by the proposed transferee, assignee or
sublessee to be true and correct, that the proposed transferee, assignee or sublessee intends to use or store in the Premises. Additionally, Tenant shall deliver to Landlord, on or before the date any proposed transferee, assignee or sublessee takes
occupancy of the Premises, all of the items relating to Hazardous Materials of such proposed transferee, assignee or sublessee as described in Section 21.2. 
 29.5. Any Transfer that is not in compliance with the provisions of this Article shall be void and shall, at the option of Landlord, terminate this Lease. 

  
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 29.6. The consent by Landlord to a Transfer shall not relieve Tenant or proposed transferee,
assignee or sublessee from obtaining Landlord’s consent to any further Transfer, nor shall it release Tenant or any proposed transferee, assignee or sublessee of Tenant from full and primary liability under this Lease. 

29.7. Notwithstanding any Transfer, Tenant shall remain fully and primarily liable for the payment of all Rent and other sums due or to
become due hereunder, and for the full performance of all other terms, conditions and covenants to be kept and performed by Tenant. The acceptance of Rent or any other sum due hereunder, or the acceptance of performance of any other term, covenant
or condition thereof, from any person or entity other than Tenant shall not be deemed a waiver of any of the provisions of this Lease or a consent to any Transfer. 
 29.8. Other than in the case of an Exempt Transfer, if Tenant delivers to Landlord a Transfer Notice indicating a desire to transfer all (or, in the case of subleases only, a portion) of this Lease to a
proposed transferee, assignee or sublessee other than as provided within Section 29.4, then Landlord shall have the option, exercisable by giving notice to Tenant at any time within ten (10) days after Landlord’s receipt of
such Transfer Notice, to terminate this Lease with respect to such portion of the Premises being sublet as of the date specified in the Transfer Notice as the Transfer Date, except for those provisions that, by their express terms, survive the
expiration or earlier termination hereof. If Landlord exercises such option, then Tenant shall have the right to withdraw such Transfer Notice by delivering to Landlord written notice of such election within five (5) days after Landlord’s
delivery of notice electing to exercise Landlord’s option to terminate this Lease or portion hereof. In the event Tenant withdraws the Transfer Notice as provided in this Section, this Lease shall continue in full force and effect. No failure
of Landlord to exercise its option to terminate this Lease or portion hereof shall be deemed to be Landlord’s consent to a proposed Transfer. 
 29.9. If Tenant sublets the Premises or any portion thereof, Tenant hereby immediately and irrevocably assigns to Landlord, as security for Tenant’s obligations under this Lease, all rent from any
such subletting, and appoints Landlord as assignee and attorney-in-fact for Tenant, and Landlord (or a receiver for Tenant appointed on Landlord’s application) may collect such rent and apply it toward Tenant’s obligations under this
Lease; provided that, until the occurrence of a Default (as defined below) by Tenant, Tenant shall have the right to collect such rent. 

30. Subordination and Attornment. 
 30.1. Provided that Tenant’s possession and quiet enjoyment of the Premises shall not be disturbed so long as Tenant is not in Default, this Lease shall be subject and subordinate to the lien
of any mortgage, deed of trust, or lease in which Landlord is tenant now or hereafter in force against the Building or the Project and to all advances made or hereafter to be made upon the security thereof without the necessity of the execution and
delivery of any further instruments on the part of Tenant to effectuate such subordination. 
 30.2. Notwithstanding the
foregoing, Tenant shall execute and deliver upon demand such further instrument or instruments evidencing such subordination of this Lease to the lien of any such mortgage or mortgages or deeds of trust or lease in which Landlord is tenant as may be

  
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required by Landlord, which shall include language stating that, so long as Tenant is not in Default, Tenant’s possession and quiet enjoyment of the Premises shall not be disturbed by the
Mortgagee (as defined below). If any such mortgagee, beneficiary or landlord under a lease wherein Landlord is tenant (each, a “Mortgagee”) so elects, however, this Lease shall be deemed prior in lien to any such lease, mortgage, or
deed of trust upon or including the Premises regardless of date and Tenant shall execute a statement in writing to such effect at Landlord’s request. If Tenant fails to execute any document required from Tenant under this Section within ten
(10) business days after written request therefor, Tenant hereby constitutes and appoints Landlord or its special attorney-in-fact to execute and deliver any such document or documents in the name of Tenant. Such power is coupled with an
interest and is irrevocable. 
 30.3. Upon written request of Landlord and opportunity for Tenant to review, Tenant agrees to
execute any Lease amendments not materially altering the terms of this Lease, if required by a mortgagee or beneficiary of a deed of trust encumbering real property of which the Premises constitute a part incident to the financing of the real
property of which the Premises constitute a part. 
 30.4. In the event any proceedings are brought for foreclosure, or in the
event of the exercise of the power of sale under any mortgage or deed of trust made by Landlord covering the Premises, Tenant shall at the election of the purchaser at such foreclosure or sale attorn to the purchaser upon any such foreclosure or
sale and recognize such purchaser as Landlord under this Lease. 
 30.5. Upon request by Tenant and at Tenant’s sole cost,
Landlord shall provide a non-disturbance agreement from all future lenders and ground lessors of the Project on such lenders’ or ground lessors’ standard form. 
 31. Defaults and Remedies. 
 31.1. Late payment by Tenant to Landlord of
Rent and other sums due shall cause Landlord to incur costs not contemplated by this Lease, the exact amount of which shall be extremely difficult and impracticable to ascertain. Such costs include processing and accounting charges and late charges
that may be imposed on Landlord by the terms of any mortgage or trust deed covering the Premises. Therefore, if any installment of Rent due from Tenant is not received by Landlord within three (3) business days after the date such payment is
due, Tenant shall pay to Landlord (a) an additional sum of six percent (6%) of the overdue Rent as a late charge plus (b) interest at an annual rate (the “Default Rate”) equal to the lesser of (a) twelve percent
(12%) and (b) the highest rate permitted by Applicable Laws. The parties agree that this late charge represents a fair and reasonable estimate of the costs that Landlord shall incur by reason of late payment by Tenant and shall be payable
as Additional Rent to Landlord due with the next installment of Rent or within five (5) business days after Landlord’s demand, whichever is earlier. Landlord’s acceptance of any Additional Rent (including a late charge or any other
amount hereunder) shall not be deemed an extension of the date that Rent is due or prevent Landlord from pursuing any other rights or remedies under this Lease, at law or in equity. 

31.2. No payment by Tenant or receipt by Landlord of a lesser amount than the Rent payment herein stipulated shall be deemed to be other
than on account of the Rent, nor shall any 

  
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endorsement or statement on any check or any letter accompanying any check or payment as Rent be deemed an accord and satisfaction, and Landlord may accept such check or payment without prejudice
to Landlord’s right to recover the balance of such Rent or pursue any other remedy provided in this Lease or in equity or at law. If a dispute shall arise as to any amount or sum of money to be paid by Tenant to Landlord hereunder, Tenant shall
have the right to make payment “under protest,” such payment shall not be regarded as a voluntary payment, and there shall survive the right on the part of Tenant to institute suit for recovery of the payment paid under protest.

 31.3. If Tenant fails to pay any sum of money required to be paid by it hereunder, or shall fail to perform any other act on
its part to be performed hereunder, in each case within the applicable cure period (if any) described in Section 31.4, then Landlord may, without waiving or releasing Tenant from any obligations of Tenant, but shall not be obligated to,
make such payment or perform such act; provided that such failure by Tenant unreasonably interfered with the use of the Building or the Project by any other tenant or with the efficient operation of the Building or the Project, or resulted or
could have resulted in a violation of Applicable Laws or the cancellation of an insurance policy maintained by Landlord. Notwithstanding the foregoing, in the event of an emergency, Landlord shall have the right to enter the Premises and act in
accordance with its rights as provided elsewhere in this Lease. In addition to the late charge described in Section 31.1, Tenant shall pay to Landlord as Additional Rent all sums so paid or incurred by Landlord, together with interest at
the Default Rate, computed from the date such sums were paid or incurred. 
 31.4. The occurrence of any one or more of the
following events shall constitute a “Default” hereunder by Tenant: 
 (a) Tenant abandons the Premises;

 (b) Tenant fails to make any payment of Rent, as and when due, or to satisfy its obligations under Article 19, where
such failure shall continue for a period of three (3) business days after written notice thereof from Landlord to Tenant; 

(c) Tenant fails to observe or perform any obligation or covenant contained herein (other than described in Subsections 31.4(a)
and 31.4(b)) to be performed by Tenant, where such failure continues for a period of thirty (30) days after written notice thereof from Landlord to Tenant; provided that, if the nature of Tenant’s default is such that it
reasonably requires more than thirty (30) days to cure, Tenant shall not be deemed to be in Default if Tenant commences such cure within said thirty (30) day period and thereafter diligently prosecute the same to completion; and
provided, further, that such cure is completed no later than ninety (90) days after Tenant’s receipt of written notice from Landlord; 
 (d) Tenant makes an assignment for the benefit of creditors; 
 (e) A receiver,
trustee or custodian is appointed to or does take title, possession or control of all or substantially all of Tenant’s assets; 
 (f) Tenant files a voluntary petition under the United States Bankruptcy Code or any successor statute (as the same may be amended from time to time, the “Bankruptcy Code”) or an order
for relief is entered against Tenant pursuant to a voluntary or involuntary proceeding commenced under any chapter of the Bankruptcy Code; 

  
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 (g) Any involuntary petition is filed against Tenant under any chapter of the Bankruptcy
Code and is not dismissed within one hundred twenty (120) days; 
 (h) Tenant fails to deliver an estoppel certificate in
accordance with Article 20; or 
 (i) Tenant’s interest in this Lease is attached, executed upon or otherwise
judicially seized and such action is not released within one hundred twenty (120) days of the action. 
 Notices given
under this Section shall specify the alleged default and shall demand that Tenant perform the provisions of this Lease or pay the Rent that is in arrears, as the case may be, within the applicable period of time, or quit the Premises. No such notice
shall be deemed a forfeiture or a termination of this Lease unless Landlord elects otherwise in such notice. 
 31.5. In the
event of a Default by Tenant, and at any time thereafter, with or without notice or demand and without limiting Landlord in the exercise of any right or remedy that Landlord may have, Landlord has the right to do any or all of the following:

 (a) Halt any Tenant Improvements and Alterations and order Tenant’s contractors, subcontractors, consultants, designers
and material suppliers to stop work; 
 (b) Terminate Tenant’s right to possession of the Premises by written notice to
Tenant or by any lawful means, in which case Tenant shall immediately surrender possession of the Premises to Landlord. In such event, Landlord shall have the immediate right to re-enter and remove all persons and property, and such property may be
removed and stored in a public warehouse or elsewhere at the cost and for the account of Tenant, all without service of notice or resort to legal process and without being deemed guilty of trespass or becoming liable for any loss or damage that may
be occasioned thereby; and 
 (c) Terminate this Lease, in which event Tenant shall immediately surrender possession of the
Premises to Landlord. In such event, Landlord shall have the immediate right to re-enter and remove all persons and property, and such property may be removed and stored in a public warehouse or elsewhere at the cost and for the account of Tenant,
all without service of notice or resort to legal process and without being deemed guilty of trespass or becoming liable for any loss or damage that may be occasioned thereby. In the event that Landlord shall elect to so terminate this Lease, then
Landlord shall be entitled to recover from Tenant all damages incurred by Landlord by reason of Tenant’s default, including: 
 (i) The worth at the time of award of any unpaid Rent that had accrued at the time of such termination; plus 
 (ii) The worth at the time of award of the amount by which the unpaid Rent that would have accrued during the period commencing with termination of the Lease and

  
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ending at the time of award exceeds that portion of the loss of Landlord’s rental income from the Premises that Tenant proves to Landlord’s reasonable satisfaction could have been
reasonably avoided; plus 
 (iii) The worth at the time of award of the amount by which the unpaid Rent for the balance of the
Term after the time of award exceeds that portion of the loss of Landlord’s rental income from the Premises that Tenant proves to Landlord’s reasonable satisfaction could have been reasonably avoided; plus 

(iv) Any other amount necessary to compensate Landlord for all the detriment caused by Tenant’s failure to perform its obligations
under this Lease or that in the ordinary course of things would be likely to result therefrom, including the cost of restoring the Premises to the condition required under the terms of this Lease, including any rent payments not otherwise chargeable
to Tenant (e.g., during any “free” rent period or rent holiday); plus 
 (v) At Landlord’s election, such other
amounts in addition to or in lieu of the foregoing as may be permitted from time to time by Applicable Laws. 
 As used in Subsections
31.5(c)(i) and 31.5(c)(ii), “worth at the time of award” shall be computed by allowing interest at the Default Rate. As used in Subsection 31.5(c)(iii), the “worth at the time of the award” shall be computed by
taking the present value of such amount, using the discount rate of the Federal Reserve Bank of San Francisco at the time of the award plus one (1) percentage point. 
 31.6. In addition to any other remedies available to Landlord at law or in equity and under this Lease, Landlord may continue this Lease in effect after Tenant’s Default and abandonment and recover
Rent as it becomes due. In addition, Landlord shall not be liable in any way whatsoever for its failure or refusal to relet the Premises. For purposes of this Section, the following acts by Landlord will not constitute the termination of
Tenant’s right to possession of the Premises: 
 (a) Acts of maintenance or preservation or efforts to relet the Premises,
including alterations, remodeling, redecorating, repairs, replacements or painting as Landlord shall reasonably consider advisable for the purpose of reletting the Premises or any part thereof; or 

(b) The appointment of a receiver upon the initiative of Landlord to protect Landlord’s interest under this Lease or in the
Premises. 
 Notwithstanding the foregoing, in the event of a Default by Tenant, Landlord may elect at any time to terminate this Lease and to
recover damages to which Landlord is entitled. 
 31.7. If Landlord does not elect to terminate this Lease as provided in
Section 31.5, then Landlord may, from time to time, recover all Rent as it becomes due under this Lease. At any time thereafter, Landlord may elect to terminate this Lease and to recover damages to which Landlord is entitled. 

  
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 31.8. In the event Landlord elects to terminate this Lease and relet the Premises, Landlord
may execute any new lease in its own name. Tenant hereunder shall have no right or authority whatsoever to collect any Rent from such tenant. The proceeds of any such reletting shall be applied as follows: 

(a) First, to the payment of any indebtedness other than Rent due hereunder from Tenant to Landlord, including storage charges or
brokerage commissions owing from Tenant to Landlord as the result of such reletting; 
 (b) Second, to the payment of the
reasonable costs and expenses of reletting the Premises, including (i) alterations and repairs that Landlord deems reasonably necessary and advisable and (ii) reasonable attorneys’ fees, charges and disbursements incurred by Landlord
in connection with the retaking of the Premises and such reletting; 
 (c) Third, to the payment of Rent and other charges due
and unpaid hereunder; and 
 (d) Fourth, to the payment of future Rent and other damages payable by Tenant under this Lease.

 31.9. All of Landlord’s rights, options and remedies hereunder shall be construed and held to be nonexclusive and
cumulative. Landlord shall have the right to pursue any one or all of such remedies, or any other remedy or relief that may be provided by Applicable Laws, whether or not stated in this Lease. No waiver of any default of Tenant hereunder shall be
implied from any acceptance by Landlord of any Rent or other payments due hereunder or any omission by Landlord to take any action on account of such default if such default persists or is repeated, and no express waiver shall affect defaults other
than as specified in said waiver. 
 31.10. Landlord’s termination of (a) this Lease or (b) Tenant’s right
to possession of the Premises shall not relieve Tenant of any liability to Landlord that has previously accrued or that shall arise based upon events that occurred prior to the later to occur of (i) the date of Lease termination or
(ii) the date Tenant surrenders possession of the Premises. 
 31.11. To the extent permitted by Applicable Laws, Tenant
waives any and all rights of redemption granted by or under any present or future Applicable Laws if Tenant is evicted or dispossessed for any cause, or if Landlord obtains possession of the Premises due to Tenant’s default hereunder or
otherwise. 
 31.12. Landlord shall not be in default or liable for damages under this Lease unless Landlord fails to perform
obligations required of Landlord within a reasonable time, but in no event shall such failure continue for more than thirty (30) days after written notice from Tenant specifying the nature of Landlord’s failure; provided, however,
that if the nature of Landlord’s obligation is such that more than thirty (30) days are required for its performance, then Landlord shall not be in default if Landlord commences performance within such thirty (30) day period and
thereafter diligently prosecutes the same to completion. In no event shall Tenant have the right to terminate or cancel this Lease or to withhold or abate rent or to set off any Claims against Rent as a result of any default or breach by Landlord of
any of its covenants, obligations, representations, warranties or promises hereunder, except as may otherwise be expressly set forth in this Lease. 

  
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 31.13. In the event of any default by Landlord, Tenant shall give notice by registered or
certified mail to any (a) beneficiary of a deed of trust or (b) mortgagee under a mortgage covering the Premises, the Building or the Project and to any landlord of any lease of land upon or within which the Premises, the Building or the
Project is located, and shall offer such beneficiary, mortgagee or landlord a reasonable opportunity to cure the default; provided that Landlord shall furnish to Tenant in writing, upon written request by Tenant, the names and addresses of
all such persons who are to receive such notices. 
 32. Bankruptcy. In the event a debtor, trustee or debtor in possession under the
Bankruptcy Code, or another person with similar rights, duties and powers under any other Applicable Laws, proposes to cure any default under this Lease or to assume or assign this Lease and is obliged to provide adequate assurance to Landlord that
(a) a default shall be cured, (b) Landlord shall be compensated for its damages arising from any breach of this Lease and (c) future performance of Tenant’s obligations under this Lease shall occur, then such adequate assurances
shall include any or all of the following, as designated by Landlord in its sole and absolute discretion: 
 32.1. Those acts
specified in the Bankruptcy Code or other Applicable Laws as included within the meaning of “adequate assurance,” even if this Lease does not concern a shopping center or other facility described in such Applicable Laws; 

32.2. A prompt cash payment to compensate Landlord for any monetary defaults or actual damages arising directly from a breach of this
Lease; 
 32.3. A cash deposit in an amount at least equal to the then-current amount of the Security Deposit; or 

32.4. The assumption or assignment of all of Tenant’s interest and obligations under this Lease. 

33. Brokers. 
 33.1.
Tenant represents and warrants that it has had no dealings with any real estate broker or agent in connection with the negotiation of this Lease other than Richards Barry Joyce & Partners (“Broker”), and that it knows of no
other real estate broker or agent that is or might be entitled to a commission in connection with this Lease. Landlord shall compensate Broker in relation to this Lease pursuant to a separate agreement between Landlord and Broker. 

33.2. Tenant represents and warrants that no broker or agent has made any representation or warranty relied upon by Tenant in
Tenant’s decision to enter into this Lease, other than as contained in this Lease. 
 33.3. Tenant acknowledges and agrees
that the employment of brokers by Landlord is for the purpose of solicitation of offers of leases from prospective tenants and that no authority is granted to any broker to furnish any representation (written or oral) or warranty from Landlord
unless expressly contained within this Lease. Landlord is executing this Lease in reliance upon Tenant’s representations, warranties and agreements contained within Sections 33.1 and 33.2. 

  
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 33.4. Tenant agrees to indemnify, save, defend (at Landlord’s option and with counsel
reasonably acceptable to Landlord) and hold the Landlord Indemnitees harmless from any and all cost or liability for compensation claimed by any broker or agent, other than Broker, employed or engaged by it or claiming to have been employed or
engaged by it. Landlord agrees to indemnify, save, defend (at Tenant’s option and with counsel reasonably acceptable to Tenant) and hold the Tenant Indemnitees harmless from any and all cost or liability for compensation claimed by any broker
or agent employed or engaged by it or claiming to have been employed or engaged by it. 
 34. Definition of Landlord. With regard to
obligations imposed upon Landlord pursuant to this Lease, the term “Landlord,” as used in this Lease, shall refer only to Landlord or Landlord’s then-current successor-in-interest. In the event of any transfer, assignment or
conveyance of Landlord’s interest in this Lease or in Landlord’s fee title to or leasehold interest in the Property, as applicable, Landlord herein named (and in case of any subsequent transfers or conveyances, the subsequent Landlord)
shall be automatically freed and relieved, from and after the date of such transfer, assignment or conveyance, from all liability for the performance of any covenants or obligations contained in this Lease thereafter to be performed by Landlord and,
without further agreement, the transferee, assignee or conveyee of Landlord’s in this Lease or in Landlord’s fee title to or leasehold interest in the Property, as applicable, shall be deemed to have assumed and agreed to observe and
perform any and all covenants and obligations of Landlord hereunder during the tenure of its interest in the Lease or the Property. Landlord or any subsequent Landlord may transfer its interest in the Premises or this Lease without Tenant’s
consent. 
 35. Limitation of Landlord’s Liability. 
 35.1. If Landlord is in default under this Lease and, as a consequence, Tenant recovers a monetary judgment against Landlord, the judgment shall be satisfied only out of (a) the proceeds of sale
received on execution of the judgment and levy against the right, title and interest of Landlord in the Building and the Project, (b) rent or other income from such real property receivable by Landlord or (c) the consideration received by
Landlord from the sale, financing, refinancing or other disposition of all or any part of Landlord’s right, title or interest in the Building or the Project. 
 35.2. Landlord shall not be personally liable for any deficiency under this Lease. If Landlord is a partnership or joint venture, then the partners of such partnership shall not be personally liable for
Landlord’s obligations under this Lease, and no partner of Landlord shall be sued or named as a party in any suit or action, and service of process shall not be made against any partner of Landlord except as may be necessary to secure
jurisdiction of the partnership or joint venture. If Landlord is a corporation, then the shareholders, directors, officers, employees and agents of such corporation shall not be personally liable for Landlord’s obligations under this Lease, and
no shareholder, director, officer, employee or agent of Landlord shall be sued or named as a party in any suit or action, and service of process shall not be made against any shareholder, director, officer, employee or agent of Landlord. If Landlord
is a limited liability 

  
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company, then the members of such limited liability company shall not be personally liable for Landlord’s obligations under this Lease, and no member of Landlord shall be sued or named as a
party in any suit or action, and service of process shall not be made against any member of Landlord except as may be necessary to secure jurisdiction of the limited liability company. No partner, shareholder, director, employee, member or agent of
Landlord shall be required to answer or otherwise plead to any service of process, and no judgment shall be taken or writ of execution levied against any partner, shareholder, director, employee, member or agent of Landlord. 

35.3. Each of the covenants and agreements of this Article shall be applicable to any covenant or agreement either expressly contained in
this Lease or imposed by Applicable Laws and shall survive the expiration or earlier termination of this Lease. 
 36. Joint and Several
Obligations. If more than one person or entity executes this Lease as Tenant, then: 
 36.1. Each of them is jointly and
severally liable for the keeping, observing and performing of all of the terms, covenants, conditions, provisions and agreements of this Lease to be kept, observed or performed by Tenant; and 

36.2. The term “Tenant,” as used in this Lease shall mean and include each of them, jointly and severally. The act of,
notice from, notice to, refund to, or signature of any one or more of them with respect to the tenancy under this Lease, including any renewal, extension, expiration, termination or modification of this Lease, shall be binding upon each and all of
the persons executing this Lease as Tenant with the same force and effect as if each and all of them had so acted, so given or received such notice or refund, or so signed. 
 37. Representations. 
 37.1. Tenant guarantees, warrants and represents
that (a) Tenant is duly incorporated or otherwise established or formed and validly existing under the laws of its state of incorporation, establishment or formation, (b) Tenant has and is duly qualified to do business in the state in
which the Property is located, (c) Tenant has full corporate, partnership, trust, association or other appropriate power and authority to enter into this Lease and to perform all of Tenant’s obligations hereunder, (d) each person (and
all of the persons if more than one signs) signing this Lease on behalf of Tenant is duly and validly authorized to do so and (e) neither (i) the execution, delivery or performance of this Lease nor (ii) the consummation of the
transactions contemplated hereby will violate or conflict with any provision of documents or instruments under which Tenant is constituted or to which Tenant is a party. In addition, Tenant guarantees, warrants and represents that none of
(x) it, (y) its affiliates or partners nor (z) to the best of its knowledge, its members, shareholders or other equity owners or any of their respective employees, officers, directors, representatives or agents is a person or entity
with whom U.S. persons or entities are restricted from doing business under regulations of the Office of Foreign Asset Control (“OFAC”) of the Department of the Treasury (including those named on OFAC’s Specially Designated and
Blocked Persons List) or under any statute, executive order (including the September 24, 2001, Executive Order Blocking Property and Prohibiting Transactions with Persons Who Commit, Threaten to Commit, or Support Terrorism) or other similar
governmental action. 

  
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 37.2. Landlord guarantees, warrants and represents that
(a) Landlord is duly formed and validly existing under the laws of its state of formation, (b) Landlord has and is duly qualified to do business in the state in which the Property is located, (c) Landlord has full appropriate power
and authority to enter into this Lease and to perform all of Landlord’s obligations hereunder, (d) each person (and all of the persons if more than one signs) signing this Lease on behalf of Landlord is duly and validly authorized to do
so, (e) neither (i) the execution, delivery or performance of this Lease nor (ii) the consummation of the transactions contemplated hereby will violate or conflict with any provision of documents or instruments under which Landlord is
constituted or to which Landlord is a party, (f) at the time of Landlord’s delivery of the Premises, all base building systems, including HVAC, electrical, life safety and plumbing, shall be in good working condition and suitable for
laboratory uses, (g) the Premises and Common Areas, with the exception of mechanical areas and certain water-damaged drywall and carpeting (which Landlord shall replace at its sole cost and expense no later than August 31, 2011), will
comply with the ADA and any state and local accessibility Applicable Laws (in the case of the first (1st) floor Premises, taking into account the core and shell condition of such Premises), and (h) at the time of Landlord’s delivery of the Premises, all demising walls and Common Area corridors
will comply with Applicable Laws, with the exception of certain water-damaged drywall and carpeting (which Landlord shall replace at its sole cost and expense no later than August 31, 2011). 

38. Confidentiality. Tenant shall keep the terms and conditions of this Lease and any information provided to Tenant or its employees, agents or
contractors pursuant to Article 9 confidential and shall not (a) disclose to any third party any terms or conditions of this Lease or any other Lease-related document (including subleases, assignments, work letters, construction
contracts, letters of credit, subordination agreements, non-disturbance agreements, brokerage agreements or estoppels) or (b) provide to any third party an original or copy of this Lease (or any Lease-related document). Landlord shall not
release to any third party any non-public financial information, non-public information about Tenant’s ownership structure, and any other non-public information with respect to Tenant or Tenant’s business that Tenant gives Landlord and
marks as confidential. Notwithstanding the foregoing, confidential information under this Section may be released by Landlord or Tenant under the following circumstances: (x) if required by Applicable Laws or in any judicial proceeding;
provided that the releasing party has given the other party reasonable notice of such requirement, if feasible, (y) to a party’s attorneys, accountants, brokers and other bona fide consultants or advisers (with respect to this Lease
only); provided such third parties agree to be bound by this Section or (z) to bona fide prospective assignees or subtenants of this Lease; provided they agree in writing to be bound by this Section. The parties agree that breach
of this Section could cause irreparable harm, and the parties shall be entitled to injunctive relief to enforce the provisions of this Section. 

39. Notices. Any notice, consent, demand, bill, statement or other communication required or permitted to be given hereunder shall be in writing
and shall be given by personal delivery, overnight delivery with a reputable nationwide overnight delivery service, or certified mail (return receipt requested), and if given by personal delivery, shall be deemed delivered upon receipt; if given by
overnight delivery, shall be deemed delivered one (1) business day after 

  
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deposit with a reputable nationwide overnight delivery service; and, if given by certified mail (return receipt requested), shall be deemed delivered three (3) business days after the time
the notifying party deposits the notice with the United States Postal Service. Any notices given pursuant to this Lease shall be addressed to Tenant at the Premises, or to Landlord or Tenant at the addresses shown in Sections 2.9 and
2.10, respectively. Either party may, by notice to the other given pursuant to this Section, specify additional or different addresses for notice purposes. 
 40. Rooftop Installation Area. 
 40.1. Tenant may use those portions of the
Building identified as a “Tenant Roof Area” on Exhibit A attached hereto (the “Rooftop Installation Area”) solely to operate, maintain, repair and replace rooftop antennae, satellite dishes, HVAC equipment,
mechanical equipment, communications antennas and other equipment installed by Tenant in the Rooftop Installation Area in accordance with this Article (“Tenant’s Rooftop Equipment”). Tenant’s Rooftop Equipment shall be
only for Tenant’s use of the Premises for the Permitted Use. 
 40.2. Tenant shall install Tenant’s Rooftop Equipment
at its sole cost and expense, at such times and in such manner as Landlord may reasonably designate, and in accordance with this Article and the applicable provisions of this Lease regarding Alterations. Tenant’s Rooftop Equipment and the
installation thereof shall be subject to Landlord’s prior written approval, which approval shall not be unreasonably withheld, delayed or conditioned. Among other reasons, Landlord may withhold approval if the installation or operation of
Tenant’s Rooftop Equipment could reasonably be expected to damage the structural integrity of the Building or to transmit vibrations or noise or cause other adverse effects beyond the Premises to an extent not customary in first class
laboratory Buildings, unless Tenant implements measures that are acceptable to Landlord in its reasonable discretion to avoid any such damage or transmission. 
 40.3. Tenant shall comply with any roof or roof-related warranties. Tenant shall obtain a letter from Landlord’s roofing contractor within thirty (30) days after completion of any Tenant work on
the rooftop stating that such work did not affect any such warranties. Tenant, at its sole cost and expense, shall inspect the Rooftop Installation Area at least annually, and correct any loose bolts, fittings or other appurtenances and repair any
damage to the roof caused by the installation or operation of Tenant’s Rooftop Equipment. Tenant shall not permit the installation, maintenance or operation of Tenant’s Rooftop Equipment to violate any Applicable Laws or constitute a
nuisance. Tenant shall pay Landlord within thirty (30) days after demand (a) all applicable taxes, charges, fees or impositions imposed on Landlord by Governmental Authorities as the result of Tenant’s use of the Rooftop Installation
Areas in excess of those for which Landlord would otherwise be responsible for the use or installation of Tenant’s Rooftop Equipment and (b) the amount of any increase in Landlord’s insurance premiums as a result of the installation
of Tenant’s Rooftop Equipment. Upon Tenant’s written request to Landlord, Landlord shall use commercially reasonable efforts to cause other tenants to remedy any interference in the operation of Tenant’s Rooftop Equipment caused by
any such tenants’ equipment installed after the applicable piece of Tenant’s Rooftop Equipment; provided, however, that Landlord shall not be required to request that such tenants waive their rights under their respective leases.

  
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 40.4. If Tenant’s Equipment (a) causes physical damage to the structural integrity
of the Building, (b) interferes with any telecommunications, mechanical or other systems located at or near or servicing the Building or the Project that were installed prior to the installation of Tenant’s Rooftop Equipment,
(c) interferes with any other service provided to other tenants in the Building or the Project by rooftop or penthouse installations that were installed prior to the installation of Tenant’s Rooftop Equipment or (d) interferes with
any other tenants’ business, in each case in excess of that permissible under Federal Communications Commission regulations, then Tenant shall cooperate with Landlord to determine the source of the damage or interference and promptly repair
such damage and eliminate such interference, in each case at Tenant’s sole cost and expense, within ten (10) business days after receipt of notice of such damage or interference (which notice may be oral; provided that Landlord also
delivers to Tenant written notice of such damage or interference within twenty-four (24) hours after providing oral notice). 
 40.5. Landlord reserves the right to cause Tenant to relocate Tenant’s Rooftop Equipment to comparably functional space on the roof or in the penthouse of the Building by giving Tenant prior written
notice thereof. Landlord agrees to pay the reasonable costs thereof. Tenant shall arrange for the relocation of Tenant’s Rooftop Equipment within sixty (60) days after receipt of Landlord’s notification of such relocation. In the
event Tenant fails to arrange for relocation within such sixty (60)-day period, Landlord shall have the right to arrange for the relocation of Tenant’s Rooftop Equipment in a manner that does not unnecessarily interrupt or interfere with
Tenant’s use of the Premises for the Permitted Use. 
 41. Miscellaneous. 

41.1. Landlord reserves the right to change the name of the Building or the Project in its sole discretion; provided that, so long
as Tenant leases and occupies greater than fifty percent (50%) of the Building, Landlord shall not name the Building or the Project after a competitor of Tenant. 
 41.2. To induce Landlord to enter into this Lease, Tenant agrees that it shall promptly furnish to Landlord, from time to time (not to exceed one time per year), upon Landlord’s written request, the
most recent audited year-end financial statements reflecting Tenant’s current financial condition. Upon Landlord’s request, Tenant shall, within ninety (90) days after the end of Tenant’s financial year, furnish Landlord with a
certified copy of Tenant’s audited year-end financial statements for the previous year. Tenant represents and warrants that all financial statements, records and information furnished by Tenant to Landlord in connection with this Lease are
true, correct and complete in all respects. If audited financials are not otherwise prepared, unaudited financials certified by the chief financial officer of Tenant as true, correct and complete in all respects shall suffice for purposes of this
Section. 
 41.3. Where applicable in this Lease, the singular includes the plural and the masculine or neuter includes the
masculine, feminine and neuter. The words “include,” “includes,” “included” and “including” shall mean “‘include,’ etc., without limitation.” The section headings of this Lease are not a
part of this Lease and shall have no effect upon the construction or interpretation of any part hereof. 

  
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 41.4. If either party commences an action against the other party arising out of or in
connection with this Lease, then the substantially prevailing party shall be reimbursed by the other party for all reasonable costs and expenses, including reasonable attorneys’ fees and expenses, incurred by the substantially prevailing party
in such action or proceeding and in any appeal in connection therewith. 
 41.5. Submission of this instrument for examination
or signature by Tenant does not constitute a reservation of or option for a lease, and shall not be effective as a lease or otherwise until execution by and delivery to both Landlord and Tenant. 

41.6. Time is of the essence with respect to the performance of every provision of this Lease in which time of performance is a factor.

 41.7. Each provision of this Lease performable by Tenant shall be deemed both a covenant and a condition. 

41.8. Whenever consent or approval of either party is required, that party shall not unreasonably withhold, delay or condition such
consent or approval, except as may be expressly set forth herein to the contrary. 
 41.9. The terms of this Lease are intended
by the parties as a final expression of their agreement with respect to the terms as are included herein, and may not be contradicted by evidence of any prior or contemporaneous agreement. 

41.10. Any provision of this Lease that shall prove to be invalid, void or illegal shall in no way affect, impair or invalidate any other
provision hereof, and all other provisions of this Lease shall remain in full force and effect and shall be interpreted as if the invalid, void or illegal provision did not exist. 

41.11. Upon the request of either party, the other party shall execute and deliver, and the requesting party shall be entitled to record,
a short form or memorandum hereof. Within ten (10) days after receipt of written request from Landlord, Tenant shall execute a termination of any short form or memorandum of lease recorded with respect hereto. Neither party shall record this
Lease. 
 41.12. The language in all parts of this Lease shall be in all cases construed as a whole according to its fair
meaning and not strictly for or against either Landlord or Tenant. 
 41.13. Each of the covenants, conditions and agreements
herein contained shall inure to the benefit of and shall apply to and be binding upon the parties hereto and their respective heirs; legatees; devisees; executors; administrators; and permitted successors, assigns, sublessees. Nothing in this
Section shall in any way alter the provisions of this Lease restricting assignment or subletting. 
 41.14. This Lease shall be
governed by, construed and enforced in accordance with the laws of the state in which the Premises are located, without regard to such state’s conflict of law principles. 

  
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 41.15. Tenant guarantees, warrants and represents that the individual or individuals signing
this Lease have the power, authority and legal capacity to sign this Lease on behalf of and to bind all entities, corporations, partnerships, limited liability companies, joint venturers or other organizations and entities on whose behalf said
individual or individuals have signed. 
 41.16. This Lease may be executed in one or more counterparts, each of which, when
taken together, shall constitute one and the same document. 
 41.17. No provision of this Lease may be modified, amended or
supplemented except by an agreement in writing signed by Landlord and Tenant. The waiver by Landlord of any breach by Tenant of any term, covenant or condition herein contained shall not be deemed to be a waiver of any subsequent breach of the same
or any other term, covenant or condition herein contained. 
 41.18. To the extent permitted by Applicable Laws, the parties
waive trial by jury in any action, proceeding or counterclaim brought by the other party hereto related to matters arising out of or in any way connected with this Lease; the relationship between Landlord and Tenant; Tenant’s use or occupancy
of the Premises; or any claim of injury or damage related to this Lease or the Premises. 
 42. Options to Extend Term. Tenant shall have
two (2) options (each, an “Option”) to extend the Term by three (3) years each as to the entire Premises (and no less than the entire Premises) (each, an “Option Term”) upon the following terms and
conditions. Any extension of the Term pursuant to an Option shall be on all the same terms and conditions as this Lease, except as follows: 
 42.1. Base Rent shall be adjusted on the first (1st) day of an Option Term to a rate equal to the greater of (a) fair market value for laboratory and office space in the Mid-Cambridge submarket of comparable age, quality, level of finish, and
proximity to amenities and public transit (“FMV”) and (b) the Base Rent in effect at the expiration of the then-current Term. If Landlord and Tenant cannot agree on the FMV for an Option Term within thirty (30) days after
the date on which Tenant notifies Landlord that it is exercising such Option, then, no later than an additional thirty (30) days thereafter (the “Submission Period”), Landlord and Tenant shall each furnish to the other a notice
in writing (an “FMV Notice”) stating such party’s estimate of the FMV. Such notices shall be accompanied by a statement from a qualified, licensed real estate appraiser with at least ten (10) years’ experience in the
Mid-Cambridge submarket (an “Appraiser”) stating such Appraiser’s opinion of FMV. If only one (1) party’s Appraiser timely submits its opinion of FMV, such FMV shall be binding on Landlord and Tenant. If, within
twenty (20) days after expiration of the Submission Period, Landlord and Tenant still cannot agree on the FMV, the two (2) Appraisers shall appoint a third qualified, licensed real estate appraiser (the “Referee”) within
seven (7) days. If the Appraisers are unable to agree upon the selection of the Referee, then the Referee shall be selected within ten (10) days thereafter from among the Massachusetts panel of qualified Real Estate Industry Arbitrators of
the American Arbitrator Association (the “Association”) pursuant to the Real Estate Industry Arbitration rules of the Association. The Referee shall, within thirty (30) days after appointment, render the Referee’s decision
as to the FMV, which opinion shall be strictly limited to choosing one of the two determinations made by the Appraisers. The decision by the Referee shall be binding upon 

  
 52 

 
Landlord and Tenant, and each shall pay for its own appraisal. The cost of the Referee shall be shared equally by Landlord and Tenant. In determining FMV, Landlord, Tenant and, if applicable, the
Appraisers and Referee shall each take into account all relevant factors, including, without limitation, (a) the size of the Premises and length of the Option Term, (b) rent in comparable buildings in the relevant competitive market,
including concessions offered to new tenants, such as free rent, tenant improvement allowances, and moving allowances, (c) Tenant’s creditworthiness and (d) the quality and location of the Building and the Project. Base Rent during
any Option Term shall be increased on each annual anniversary of the Option Term commencement date by three percent (3%). 

42.2. The Options are not assignable separate and apart from this Lease. 

42.3. An Option is conditional upon Tenant giving Landlord written notice of its election to exercise such Option at least nine
(9) months prior to the end of the expiration of the then-current Term. Time shall be of the essence as to Tenant’s exercise of an Option. Tenant assumes full responsibility for maintaining a record of the deadlines to exercise an Option.
Tenant acknowledges that it would be inequitable to require Landlord to accept any exercise of an Option after the date provided for in this Section. 
 42.4. Notwithstanding anything contained in this Article to the contrary, Tenant shall not have the right to exercise an Option: 
 (a) During the time commencing from the date Landlord delivers to Tenant a written notice that Tenant is in default under any provisions of this Lease and continuing until Tenant has cured the specified
default to Landlord’s reasonable satisfaction; or 
 (b) At any time after any Default as described in Article 31 of
the Lease and continuing until Tenant cures any such Default, if such Default is susceptible to being cured; or 
 (c) In the
event that Tenant has defaulted in the performance of its obligations under this Lease two (2) or more times, and a service or late charge has become payable under Section 31.1 for each of such defaults, during the twelve (12)-month
period immediately prior to the date that Tenant intends to exercise an Option, whether or not Tenant has cured such defaults. 

42.5. The period of time within which Tenant may exercise an Option shall not be extended or enlarged by reason of Tenant’s
inability to exercise such Option because of the provisions of Section 42.4. 
 42.6. All of Tenant’s rights
under the provisions of an Option shall terminate and be of no further force or effect even after Tenant’s due and timely exercise of such Option if, after such exercise, but prior to the commencement date of such Option Term, (a) Tenant
fails to pay to Landlord a monetary obligation of Tenant for a period of twenty (20) days after written notice from Landlord to Tenant, (b) Tenant fails to commence to cure a default (other than a monetary default) within thirty
(30) days after the date Landlord gives notice to Tenant of such default or (c) Tenant has defaulted under this Lease two (2) or more times, and a service or late charge under Section 31.1 has become payable for any such
default, during the twelve (12) month period immediately prior to the commencement date of an Option Term, whether or not Tenant has cured such defaults. 

  
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 43. Right of First Offer. Subject to any rights existing as of the Execution Date, Tenant shall have
a continuous right of first offer (“ROFO”) as to any rentable premises in the Building for which Landlord is seeking a tenant (“Available ROFO Premises”); provided, however, that in no event shall Landlord be
required to lease any Available ROFO Premises to Tenant for any period past the date on which this Lease expires or is terminated pursuant to its terms. To the extent that Landlord renews or extends a then-existing lease with any then-existing
tenant of any space, or enters into a new lease for its existing space with such then-existing tenant, the affected space shall not be deemed to be Available ROFO Premises. In the event Landlord intends to market Available ROFO Premises, Landlord
shall provide written notice thereof to Tenant setting forth the Base Rent and other material terms upon which it will market such Available ROFO Premises (the “Notice of Marketing”). 

43.1. Within ten (10) business days following its receipt of a Notice of Marketing, Tenant shall advise Landlord in writing whether
Tenant elects to lease all (not just a portion) of the Available ROFO Premises on the terms and conditions set forth in the Notice of Marketing (other than the term set forth therein). If Tenant fails to notify Landlord of Tenant’s election
within said ten (10) business day period, then Tenant shall be deemed to have elected not to lease the Available ROFO Premises on such terms and conditions. 
 43.2. If Tenant timely notifies Landlord that Tenant elects to lease all of the Available ROFO Premises on the terms and conditions contained in the Notice of Marketing for at least the remainder of the
Term (including any Option Terms), then Landlord and Tenant shall execute an amendment hereto effecting such terms. 
 43.3. If
(a) Tenant notifies Landlord that Tenant elects not to lease the Available ROFO Premises or (b) Tenant fails to notify Landlord of Tenant’s election within the ten (10) business-day period described above on the terms and
conditions set forth in the Notice of Marketing, then Landlord shall have the right to consummate a lease of the Available ROFO Premises on overall economic terms (taking into account the base rent, tenant improvement allowance, brokerage costs,
free rent and all other incentives) not less than ninety-five percent (95%) of that stated in the Notice of Marketing. 

43.4. Notwithstanding anything in this Article to the contrary, Tenant shall not exercise the ROFO, and the ROFO shall be deemed not to
exist, (a) during such period of time after Tenant has received written notice of a default under any provision of this Lease until such default is timely cured and (b) unless Tenant has at least two (2) years remaining on the Term or
Options remain that Tenant is still entitled to exercise. Any attempted exercise of the ROFO shall be void and of no effect during a period of time in which Tenant (y) is so in default (provided that Tenant shall be able to exercise the
ROFO following timely cure of such default) or (z) has less than two (2) years remaining on the Term or Options remain that Tenant is still entitled to exercise. In addition, Tenant shall not be entitled to exercise the ROFO in the event
that Tenant has defaulted in the performance of its obligations under this Lease two (2) or more times, and a service or late charge has become payable under Section 31.1 for each of such defaults, during the twelve (12)-month
period immediately prior to the date on which Tenant seeks to exercise the ROFO, whether or not Tenant has cured such defaults. 

  
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 43.5. Notwithstanding anything in this Lease to the contrary, Tenant shall not assign or
transfer the ROFO separately from any assignment or transfer of Tenant’s interest in the Lease without Landlord’s prior written consent, which consent Landlord may withhold in its sole and absolute discretion. 

43.6. If Tenant exercises the ROFO, Landlord does not guarantee that the Available ROFO Premises will be available on the anticipated
commencement date for the Lease as to such Premises due to a holdover by the then-existing occupants of the Available ROFO Premises or for any other reason beyond Landlord’s reasonable control. 

[REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK] 

  
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 IN WITNESS WHEREOF, Landlord and Tenant have executed this Work Letter to be effective on
the date first above written. 
  

			
	LANDLORD:
	 BMR-325 VASSAR STREET LLC,
 a Delaware limited liability company

		
	By:	 	/s/ John Bonanno
	Name:	 	 JOHN BONANNO

	Title:	 	 SENIOR VICE PRESIDENT, LEASING & DEVELOPMENT

	
	TENANT:
	 BIND BIOSCIENCES, INC.,
 a Delaware corporation

		
	By:	 	/s/ Andrea Franz
	Name:	 	 ANDREA FRANZ

	Title:	 	 CFO

 EXHIBIT A 
 PREMISES 

  
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 EXHIBIT B 
 WORK LETTER 
 This Work Letter (this
“Work Letter”) is made and entered into as of the 20th day of July, 2011, by and between BMR-325 VASSAR STREET LLC, a Delaware limited liability company (“Landlord”), and BIND BIOSCIENCES, INC., a Delaware corporation
(“Tenant”), and is attached to and made a part of that certain Lease dated as of July 20, 2011 (as the same may be amended, amended and restated, supplemented or otherwise modified from time to time, the
“Lease”), by and between Landlord and Tenant for the Premises located at 325 Vassar Street, Cambridge, Massachusetts. All capitalized terms used but not otherwise defined herein shall have the meanings given them in the Lease.

 1. General Requirements. 
 1.1. Authorized Representatives. 
 (a) Landlord designates, as
Landlord’s authorized representative (“Landlord’s Authorized Representative”), (a) Sal Zinno as the person authorized to initial plans, drawings and approvals pursuant to this Work Letter and (b) John Bonanno as
the person authorized to initial plans, drawings, approvals and to sign change orders pursuant to this Work Letter and any amendments to this Work Letter or the Lease. Tenant shall not be obligated to respond to or act upon any such item until such
item has been initialed or signed (as applicable) by the appropriate Landlord’s Authorized Representative. Landlord may change either Landlord’s Authorized Representative upon one (1) business day’s prior written notice to
Tenant. 
 (b) Tenant designates Andrea Franz (“Tenant’s Authorized Representative”) as the person
authorized to initial and sign all plans, drawings, change orders and approvals pursuant to this Work Letter. Landlord shall not be obligated to respond to or act upon any such item until such item has been initialed or signed (as applicable) by
Tenant’s Authorized Representative. Tenant may change Tenant’s Authorized Representative upon one (1) business day’s prior written notice to Landlord. 
 1.2. Schedule. The schedule for design and development of the Tenant Improvements, including the time periods for preparation and review of construction documents, approvals and performance, shall
be in accordance with a schedule to be prepared by Tenant (the “Schedule”). Tenant shall prepare the Schedule so that it is a reasonable schedule for the completion of the Tenant Improvements. As soon as the Schedule is completed,
Tenant shall deliver the same to Landlord for Landlord’s approval, which approval shall not be unreasonably withheld, conditioned or delayed. Such Schedule shall be approved or disapproved by Landlord within ten (10) business days after
delivery to Landlord. Landlord’s failure to respond within such ten (10) business day period shall be deemed approval by Landlord. If Landlord disapproves the Schedule, then Landlord shall notify Tenant in writing of its objections to such
Schedule, and the parties shall confer and negotiate in good faith to reach agreement on the Schedule. The Schedule shall be subject to adjustment as mutually agreed upon in writing by the parties, or as provided in this Work Letter. 

  
 B-2

 1.3. Tenant’s Architects, Contractors and Consultants. The architect,
engineering consultants, design team, general contractor and principal subcontractors responsible for the construction of the Tenant Improvements shall be selected by Tenant and approved by Landlord, which approval Landlord shall not unreasonably
withhold, condition or delay. Landlord may refuse to use any architects, consultants, contractors, subcontractors or material suppliers that Landlord reasonably believes are likely to cause labor disharmony. All Tenant contracts related to the
Tenant Improvements shall provide that Tenant may assign such contracts to Landlord at any time. 
 2. Tenant Improvements. All Tenant
Improvements shall be performed by Tenant’s contractor, at Tenant’s sole cost and expense (subject to Landlord’s obligations with respect to any portion of the TI Allowance and in accordance with the Approved Plans (as defined below),
the Lease and this Work Letter. To the extent that the total projected cost of the Tenant Improvements (as reasonably agreed by Landlord and Tenant) exceeds the TI Allowance (such excess, the “Excess TI Costs”), Tenant shall pay the
costs of the Tenant Improvements on a pari passu basis with Landlord as such costs become due, in the proportion of Excess TI Costs payable by Tenant. In the event that the Excess TI Costs are less than projected, Landlord shall reimburse Tenant
from the TI Allowance within thirty (30) days after completion of the Tenant Improvements for the amount of Excess TI Costs overpaid by Tenant. If Tenant fails to pay, or is late in paying, any sum due to Landlord under this Work Letter, then
Landlord shall have all of the rights and remedies set forth in the Lease for nonpayment of Rent (subject to applicable cure periods in the Lease, and including the right to interest and the right to assess a late charge), and for purposes of any
litigation instituted with regard to such amounts the same shall be considered Rent. All material and equipment furnished by Tenant or its contractors as the Tenant Improvements shall be new or “like new;” the Tenant Improvements shall be
performed in a first-class, workmanlike manner; and the quality of the Tenant Improvements shall be of a nature and character not less than the Building Standard. Tenant shall take, and shall its contractors to take, commercially reasonable steps to
protect the Premises during the performance of any Tenant Improvements, including covering or temporarily removing any window coverings so as to guard against dust, debris or damage. Subject to Landlord’s approval, which shall not be
unreasonably withheld, conditioned or delayed, Tenant may install an exhaust duct vertically on the exterior of the east or north side of the Building to support Tenant’s first floor vivarium operation; provided that (a) such duct
shall, in Landlord’s reasonable determination, match the façade of the Building, (b) Landlord and Tenant shall reasonably agree on the path and location of the duct and (c) upon Landlord’s request, Tenant shall remove such
duct upon the expiration or earlier termination of the Lease at its sole cost and expense and repair any damage caused thereby. As part of the Tenant Improvements, Tenant may, subject to Applicable Laws and at its sole cost and expense, install a
one thousand five hundred (1,500) liter liquid nitrogen tank (the “Liquid Nitrogen Tank”) in the location outlined on Exhibit D attached hereto and, if necessary, Landlord may relocate the bike rack located in that area
to another location at Tenant’s sole cost and expense. 
 2.1. Work Plans. Tenant shall prepare and submit to
Landlord for approval schematics covering the Tenant Improvements prepared in conformity with the applicable provisions of this Work Letter (the “Draft Schematic Plans”). The Draft Schematic Plans shall contain sufficient
information and detail to accurately describe the proposed design to Landlord and such other information as Landlord may reasonably request. Landlord shall notify Tenant in 

 
writing within ten (10) business days after receipt of the Draft Schematic Plans whether Landlord approves or objects to the Draft Schematic Plans and of the manner, if any, in which the
Draft Schematic Plans are unacceptable. Landlord’s failure to respond within such ten (10) business day period shall be deemed approval by Landlord. If Landlord reasonably objects to the Draft Schematic Plans, then Tenant shall revise the
Draft Schematic Plans and cause Landlord’s objections to be remedied in the revised Draft Schematic Plans. Tenant shall then resubmit the revised Draft Schematic Plans to Landlord for approval, such approval not to be unreasonably withheld,
conditioned or delayed. Landlord’s approval of or objection to revised Draft Schematic Plans and Tenant’s correction of the same shall be in accordance with this Section until Landlord has approved the Draft Schematic Plans in writing or
been deemed to have approved them. The iteration of the Draft Schematic Plans that is approved or deemed approved by Landlord without objection shall be referred to herein as the “Approved Schematic Plans.” 

2.2. Construction Plans. Tenant shall prepare final plans and specifications for the Tenant Improvements that (a) are
consistent with and are logical evolutions of the Approved Schematic Plans and (b) incorporate any other Tenant-requested (and Landlord-approved) Changes (as defined below). As soon as such final plans and specifications (“Construction
Plans”) are completed, Tenant shall deliver the same to Landlord for Landlord’s approval, which approval shall not be unreasonably withheld, conditioned or delayed. Such Construction Plans shall be approved or disapproved by Landlord
within ten (10) business days after delivery to Landlord. Landlord’s failure to respond within such ten (10) business day period shall be deemed approval by Landlord. If the Construction Plans are disapproved by Landlord, then
Landlord shall notify Tenant in writing of its objections to such Construction Plans, and the parties shall confer and negotiate in good faith to reach agreement on the Construction Plans. Promptly after the Construction Plans are approved by
Landlord and Tenant, two (2) copies of such Construction Plans shall be initialed and dated by Landlord and Tenant, and Tenant shall promptly submit such Construction Plans to all appropriate Governmental Authorities for approval. The
Construction Plans so approved, and all change orders specifically permitted by this Work Letter, are referred to herein as the “Approved Plans.” 
 2.3. Changes to the Tenant Improvements. Any changes to the Approved Plans (each, a “Change”) shall be requested and instituted in accordance with the provisions of this Article
2 and shall be subject to the written approval of the non-requesting party in accordance with this Work Letter. 
 (a)
Change Request. Either Landlord or Tenant may request Changes after Landlord approves the Approved Plans by notifying the other party thereof in writing in substantially the same form as the AIA standard change order form (a “Change
Request”), which Change Request shall detail the nature and extent of any requested Changes, including (a) the Change, (b) the party required to perform the Change and (c) any modification of the Approved Plans and the
Schedule, as applicable, necessitated by the Change. If the nature of a Change requires revisions to the Approved Plans, then the requesting party shall be solely responsible for the cost and expense of such revisions and any increases in the cost
of the Tenant Improvements as a result of such Change. Change Requests shall be signed by the requesting party’s Authorized Representative. 

 (b) Approval of Changes. All Change Requests shall be subject to the other
party’s prior written approval, which approval shall not be unreasonably withheld, conditioned or delayed. The non-requesting party shall have five (5) business days after receipt of a Change Request to notify the requesting party in
writing of the non-requesting party’s decision either to approve or object to the Change Request. The non-requesting party’s failure to respond within such five (5) business day period shall be deemed approval by the non-requesting
party. 
 2.4. Preparation of Estimates. Tenant shall, before proceeding with any Change, using its best efforts, prepare
as soon as is reasonably practicable (but in no event more than five (5) business days after delivering a Change Request to Landlord or receipt of a Change Request) an estimate of the increased costs or savings that would result from such
Change, as well as an estimate on such Change’s effects on the Schedule. Landlord shall have five (5) business days after receipt of such information from Tenant to (a) in the case of a Tenant-initiated Change Request, approve or
reject such Change Request in writing, or (b) in the case of a Landlord-initiated Change Request, notify Tenant in writing of Landlord’s decision either to proceed with or abandon the Landlord-initiated Change Request. 

3. Completion of Tenant Improvements. Tenant, at its sole cost and expense (except for the TI Allowance, shall perform and complete the Tenant
Improvements in all respects (a) in substantial conformance with the Approved Plans, (b) otherwise in compliance with provisions of the Lease and this Work Letter and (c) in accordance with Applicable Laws, the requirements of
Tenant’s insurance carriers, the requirements of Landlord’s insurance carriers (to the extent Landlord provides its insurance carriers’ requirements to Tenant) and the board of fire underwriters having jurisdiction over the Premises.
The Tenant Improvements shall be deemed completed at such time as Tenant shall furnish to Landlord (v) evidence satisfactory to Landlord that (i) all Tenant Improvements have been completed and paid for in full (which shall be evidenced by
the architect’s certificate of completion and the general contractor’s and each subcontractor’s and material supplier’s final unconditional waivers and releases of liens, each in a form acceptable to Landlord and complying with
Applicable Laws), (ii) all Tenant Improvements have been accepted by Landlord, (iii) any and all liens related to the Tenant Improvements have either been discharged of record (by payment, bond, order of a court of competent jurisdiction
or otherwise) or waived by the party filing such lien and (iv) no security interests relating to the Tenant Improvements are outstanding, (w) all certifications and approvals with respect to the Tenant Improvements that may be required
from any Governmental Authority and any board of fire underwriters or similar body for the use and occupancy of the Premises, (x) certificates of insurance required by the Lease to be purchased and maintained by Tenant, (y) an affidavit
from Tenant’s architect certifying that all work performed in, on or about the Premises is in accordance with the Approved Plans and (z) complete drawing print sets and electronic CADD files on disc of all contract documents for work
performed by their architect and engineers in relation to the Tenant Improvements. 
 4. Insurance. 

4.1. Property Insurance. At all times during the period beginning with commencement of construction of the Tenant Improvements and
ending with final completion of the Tenant Improvements, Tenant shall maintain, or cause to be maintained (in addition to the insurance required of Tenant pursuant to the Lease), property insurance insuring Landlord and the

 
Landlord Parties, as their interests may appear. Such policy shall, on a completed values basis for the full insurable value at all times, insure against loss or damage by fire, vandalism and
malicious mischief and other such risks as are customarily covered by the so-called “broad form extended coverage endorsement” upon all Tenant Improvements and the general contractor’s and any subcontractors’ machinery, tools and
equipment, all while each forms a part of, or is contained in, the Tenant Improvements or any temporary structures on the Premises, or is adjacent thereto; provided that, for the avoidance of doubt, insurance coverage with respect to the
general contractor’s and any subcontractors’ machinery, tools and equipment shall be carried on a primary basis by such general contractor or the applicable subcontractor(s). Tenant agrees to pay any deductible, and Landlord is not
responsible for any deductible, for a claim under such insurance. Said property insurance shall contain an express waiver of any right of subrogation by the insurer against Landlord and the Landlord Parties, and shall name Landlord and its
affiliates as loss payees as their interests may appear. 
 4.2. Workers’ Compensation Insurance. At all times
during the period of construction of the Tenant Improvements, Tenant shall, or shall cause its contractors or subcontractors to, maintain statutory workers’ compensation insurance as required by Applicable Laws. 

5. Liability. Tenant assumes sole responsibility and liability for any and all injuries or the death of any persons, including Tenant’s
contractors and subcontractors and their respective employees, agents and invitees, and for any and all damages to property caused by, resulting from or arising out of any act or omission on the part of Tenant, Tenant’s contractors or
subcontractors, or their respective employees, agents and invitees in the prosecution of the Tenant Improvements. Tenant agrees to indemnify, save, defend (at Landlord’s option and with counsel reasonably acceptable to Landlord) and hold the
Landlord Indemnitees harmless from and against all Claims, excluding consequential damages, due to, because of or arising out of any and all such injuries, death or damage, whether real or alleged, and Tenant and Tenant’s contractors and
subcontractors shall assume and defend at their sole cost and expense all such Claims; provided, however, that nothing contained in this Work Letter shall be deemed to indemnify or otherwise hold Landlord harmless from or against
liability caused by Landlord’s negligence or willful misconduct. Any deficiency in design or construction of the Tenant Improvements shall be solely the responsibility of Tenant, notwithstanding the fact that Landlord may have approved of the
same in writing. 
 6. TI Allowance. 
 6.1. Application of TI Allowance. Landlord shall contribute the TI Allowance toward the costs and expenses incurred in connection with the performance of the Tenant Improvements, in accordance with
Article 4 of the Lease. If the entire TI Allowance is not applied toward or reserved for the costs of the Tenant Improvements, then Tenant shall not be entitled to a credit of such unused portion of the TI Allowance. Tenant may apply the TI
Allowance for the payment of construction and other costs in accordance with the terms and provisions of the Lease. 
 6.2.
Approval of Budget for the Tenant Improvements. Notwithstanding anything to the contrary set forth elsewhere in this Work Letter or the Lease, Landlord shall not have any obligation to expend any portion of the TI Allowance until Landlord and
Tenant shall have approved in writing the budget for the Tenant Improvements (the “Approved Budget”). Prior to 

 
Landlord’s approval of the Approved Budget, Tenant shall pay all of the costs and expenses incurred in connection with the Tenant Improvements as they become due. Landlord shall not be
obligated to reimburse Tenant for costs or expenses relating to the Tenant Improvements that exceed the amount of the TI Allowance. Landlord shall not unreasonably withhold, condition or delay its approval of any budget for Tenant Improvements that
is proposed by Tenant. 
 6.3. Advance Requests. Upon submission by Tenant to Landlord of (a) a statement (an
“Advance Request”) setting forth the total amount of the TI Allowance requested, (b) a summary of the Tenant Improvements performed using AIA standard form Application for Payment (G 702) executed by the general contractor and
by the architect, (c) invoices from the general contractor, the architect, and any subcontractors, material suppliers and other parties requesting payment with respect to the amount of the TI Allowance then being requested and
(d) conditional lien releases from the general contractor and each subcontractor, professional service provider and material supplier with respect to the Tenant Improvements performed that correspond to the Advance Request, each in a form
acceptable to Landlord and complying with Applicable Laws, then Landlord shall, within thirty (30) days following receipt by Landlord of an Advance Request and the accompanying materials required by this Section, pay to the applicable
contractors, subcontractors and material suppliers or to Tenant (for reimbursement for payments made by Tenant prior to Landlord’s approval of the Approved Budget to such contractors, subcontractors or material suppliers), as elected by
Landlord, the amount of Tenant Improvement costs set forth in such Advance Request; provided, however, that Landlord shall not be obligated to make any payments under this Section until the budget for the Tenant Improvements is approved in
accordance with Section 6.2 above, and any Advance Request under this Section shall be subject to the payment limits set forth in Section 6.2 above and Article 4 of the Lease. Notwithstanding the foregoing, Landlord
shall either pay or reimburse Tenant, as applicable, for the costs and expenses set forth in Subsection 4.2(s) of the Lease, in accordance with that Subsection, within fifteen (15) days after Tenant’s submission to Landlord of
invoices or receipts, as applicable, reasonably acceptable to Landlord for such items. Additionally, within fifteen (15) days after any final payment to any applicable contractor, subcontractor, professional service provider or material
supplier, Tenant shall deliver to Landlord an unconditional waiver and release of lien upon payment from such contractor, subcontractor, professional service provider or material supplier in a form acceptable to Landlord and complying with
Applicable Laws. 
 7. Miscellaneous. 
 7.1. Number; Headings. Where applicable in this Work Letter, the singular includes the plural and the masculine or neuter includes the masculine, feminine and neuter. The section headings of this
Work Letter are not a part of this Work Letter and shall have no effect upon the construction or interpretation of any part hereof. 
 7.2. Attorneys’ Fees. If either party commences an action against the other party arising out of or in connection with this Work Letter, then the substantially prevailing party shall be
entitled to have and recover from the other party reasonable attorneys’ fees, charges and disbursements and costs of suit. 

 7.3. Time of Essence. Time is of the essence with respect to the performance of every
provision of this Work Letter in which time of performance is a factor. 
 7.4. Covenant and Condition. Each provision of
this Work Letter performable by Tenant shall be deemed both a covenant and a condition. 
 7.5. Withholding of Consent.
Whenever consent or approval of either party is required, that party shall not unreasonably withhold, condition or delay such consent or approval, except as may be expressly set forth to the contrary. 

7.6. Invalidity. Any provision of this Work Letter that shall prove to be invalid, void or illegal shall in no way affect, impair
or invalidate any other provision hereof, and all other provisions of this Work Letter shall remain in full force and effect and shall be interpreted as if the invalid, void or illegal provision did not exist. 

7.7. Interpretation. The language in all parts of this Work Letter shall be in all cases construed as a whole according to its
fair meaning and not strictly for or against either Landlord or Tenant. 
 7.8. Successors. Each of the covenants,
conditions and agreements herein contained shall inure to the benefit of and shall apply to and be binding upon the parties hereto and their respective heirs; legatees; devisees; executors; administrators; and permitted successors, assigns,
sublessees. Nothing in this Section shall in any way alter the provisions of the Lease restricting assignment or subletting. 

7.9. Governing Law. This Work Letter shall be governed by, construed and enforced in accordance with the laws of the state in
which the Premises are located, without regard to such state’s conflict of law principles. 
 7.10. Power and
Authority. Tenant guarantees, warrants and represents that the individual or individuals signing this Work Letter have the power, authority and legal capacity to sign this Work Letter on behalf of and to bind all entities, corporations,
partnerships, limited liability companies, joint venturers or other organizations and entities on whose behalf said individual or individuals have signed. 
 7.11. Counterparts. This Work Letter may be executed in one or more counterparts, each of which, when taken together, shall constitute one and the same document. 

7.12. Amendments; Waiver. No provision of this Work Letter may be modified, amended or supplemented except by an agreement in
writing signed by Landlord and Tenant. The waiver by Landlord of any breach by Tenant of any term, covenant or condition herein contained shall not be deemed to be a waiver of any subsequent breach of the same or any other term, covenant or
condition herein contained. 
 7.13. Waiver of Jury Trial. To the extent permitted by Applicable Laws, the parties waive
trial by jury in any action, proceeding or counterclaim brought by the other party hereto related to matters arising out of or in any way connected with this Work Letter; the relationship between Landlord and Tenant; Tenant’s use or occupancy
of the Premises; or any claim of injury or damage related to this Work Letter or the Premises. 
 [REMAINDER OF THIS PAGE
INTENTIONALLY LEFT BLANK] 

 IN WITNESS WHEREOF, Landlord and Tenant have executed this Work Letter to be effective on
the date first above written. 
  

			
	LANDLORD:
	 BMR-325 VASSAR STREET LLC,
 a Delaware limited liability company

		
	By:	 	  

	Name:	 	  

	Title:	 	  

	
	TENANT:
	 BIND BIOSCIENCES, INC.,
 a Delaware corporation

		
	By:	 	  

	Name:	 	  

	Title:	 	  

 EXHIBIT C 
 ACKNOWLEDGEMENT OF TERM COMMENCEMENT DATE 
 AND TERM EXPIRATION DATE

 THIS ACKNOWLEDGEMENT OF TERM COMMENCEMENT DATE AND TERM EXPIRATION DATE is entered into as of
[            ], 20[    ], with reference to that certain Lease (the “Lease”) dated as of July 20, 2011, by BIND BIOSCIENCES, INC., a Delaware
corporation (“Tenant”), in favor of BMR-325 VASSAR STREET LLC, a Delaware limited liability company (“Landlord”). All capitalized terms used herein without definition shall have the meanings ascribed to them in the
Lease. 
 Tenant hereby confirms the following: 
 1. Tenant accepted possession of the Premises on [            ], 20[    ]. 

2. The Premises are in good order, condition and repair. 
 3. The Tenant Improvements are Substantially Complete. 
 4. All conditions of the
Lease to be performed by Landlord as a condition to the full effectiveness of the Lease have been satisfied, and Landlord has fulfilled all of its duties in the nature of inducements offered to Tenant to lease the Premises. 

5. In accordance with the provisions of Article 4 of the Lease, the Term Commencement Date is
[            ], 20[    ], and, unless the Lease is terminated prior to the Term Expiration Date pursuant to its terms, the Term Expiration Date shall be
[            ], 20[    ]. 
 6. Tenant commenced
occupancy of the Premises for the Permitted Use on [            ], 20[    ]. 
 7. The Lease is in full force and effect, and the same represents the entire agreement between Landlord and Tenant concerning the Premises[, except
[            ]]. 
 8. Tenant has no existing defenses against the
enforcement of the Lease by Landlord, and there exist no offsets or credits against Rent owed or to be owed by Tenant. 

  
 C-1

 9. The obligation to pay Rent is presently in effect and all Rent obligations on the part of
Tenant under the Lease commenced to accrue on [            ], 20[    ], with Base Rent payable commencing on the Rent Commencement Date in the amounts set forth in the
chart below, subject to the rental adjustments set forth in the Lease: 
  

															
	 Square Feet of
Rentable Area
	 	  	Base Rent per Square Foot of
Rentable Area	 	  	Monthly Base
Rent	 	  	Annual Base
Rent	 
	 	32,784	  	  	 	$44 annually	  	  	 	$120,208	  	  	 	$1,442,496	  

 10. The undersigned Tenant has not made any prior assignment, transfer, hypothecation or pledge of the
Lease or of the rents thereunder or sublease of the Premises or any portion thereof. 
 [REMAINDER OF THIS PAGE INTENTIONALLY
LEFT BLANK] 

  
 C-2

 IN WITNESS WHEREOF, Tenant has executed this Acknowledgment of Term Commencement Date and
Term Expiration Date as of the date first written above. 
  

			
	TENANT:
	
	 BIND BIOSCIENCES, INC.,
 a Delaware corporation

		
	By:	 	  

	Name:	 	  

	Title:	 	  

  
 C-3

 EXHIBIT D 
 LOCATION OF LIQUID NITROGEN TANK 

  
 D-1

 

 

 EXHIBIT E 
 FORM OF LETTER OF CREDIT 
 [On letterhead or L/C letterhead of
Issuer.] 
 LETTER OF CREDIT 
 Date:             , 200     
  

							
	  
	  	(the “Beneficiary”)	  	
	  
	  		  	
	  
	  		  	
	Attention:	 	  
	  		  	
	L/C. No.:	 	  
	  		  	
	Loan No. :	 	  
	  		  	

 Ladies and Gentlemen: 
 We establish in favor of Beneficiary our irrevocable and unconditional Letter of Credit numbered as identified above (the “L/C”) for an aggregate amount of
$            , expiring at     :00 p.m. on              or, if such day is not a Banking Day, then the next
succeeding Banking Day (such date, as extended from time to time, the “Expiry Date”). “Banking Day” means a weekday except a weekday when commercial banks in
                     are authorized or required to close. 
 We authorize Beneficiary to draw on us (the “Issuer”) for the account of              (the “Account Party”),
under the terms and conditions of this L/C. 
 Funds under this L/C are available by presenting the following documentation (the
“Drawing Documentation”): (a) the original L/C and (b) a sight draft substantially in the form of Attachment 1, with blanks filled in and bracketed items provided as appropriate. No other evidence of authority,
certificate, or documentation is required. 
 Drawing Documentation must be presented at Issuer’s office at
                     on or before the Expiry Date by personal presentation, courier or messenger service, or fax. Presentation by fax shall be
effective upon electronic confirmation of transmission as evidenced by a printed report from the sender’s fax machine. After any fax presentation, but not as a condition to its effectiveness, Beneficiary shall with reasonable promptness deliver
the original Drawing Documentation by any other means. Issuer will on request issue a receipt for Drawing Documentation. 
 We
agree, irrevocably, and irrespective of any claim by any other person, to honor drafts drawn under and in conformity with this L/C, within the maximum amount of this L/C, presented to us on or before the Expiry Date, provided we also receive
(on or before the Expiry Date) any other Drawing Documentation this L/C requires. 

  
 E-1

 We shall pay this L/C only from our own funds by check or wire transfer, in compliance with
the Drawing Documentation. 
 If Beneficiary presents proper Drawing Documentation to us on or before the Expiry Date, then we
shall pay under this L/C at or before the following time (the “Payment Deadline”): (a) if presentment is made at or before noon of any Banking Day, then the close of such Banking Day; and (b) otherwise, the close of the
next Banking Day. We waive any right to delay payment beyond the Payment Deadline. If we determine that Drawing Documentation is not proper, then we shall so advise Beneficiary in writing, specifying all grounds for our determination, within one
Banking Day after the Payment Deadline. 
 Partial drawings are permitted. This L/C shall, except to the extent reduced thereby,
survive any partial drawings. 
 We shall have no duty or right to inquire into the validity of or basis for any draw under this
L/C or any Drawing Documentation. We waive any defense based on fraud or any claim of fraud. 
 The Expiry Date shall
automatically be extended by one year (but never beyond                      (the “Outside Date”)) unless, on or before the date 90
days before any Expiry Date, we have given Beneficiary notice that the Expiry Date shall not be so extended (a “Nonrenewal Notice”). We shall promptly upon request confirm any extension of the Expiry Date under the preceding
sentence by issuing an amendment to this L/C, but such an amendment is not required for the extension to be effective. We need not give any notice of the Outside Date. 
 Beneficiary may from time to time without charge transfer this L/C, in whole but not in part, to any transferee (the “Transferee”). Issuer shall look solely to Account Party for payment
of any fee for any transfer of this L/C. Such payment is not a condition to any such transfer. Beneficiary or Transferee shall consummate such transfer by delivering to Issuer the original of this L/C and a Transfer Notice substantially in the form
of Attachment 2, purportedly signed by Beneficiary, and designating Transferee. Issuer shall promptly reissue or amend this L/C in favor of Transferee as Beneficiary. Upon any transfer, all references to Beneficiary shall automatically refer
to Transferee, who may then exercise all rights of Beneficiary. Issuer expressly consents to any transfers made from time to time in compliance with this paragraph. 
 Any notice to Beneficiary shall be in writing and delivered by hand with receipt acknowledged or by overnight delivery service such as FedEx (with proof of delivery) at the above address, or such other
address as Beneficiary may specify by written notice to Issuer. A copy of any such notice shall also be delivered, as a condition to the effectiveness of such notice, to:
                     (or such replacement as Beneficiary designates from time to time by written notice). 

No amendment that adversely affects Beneficiary shall be effective without Beneficiary’s written consent. 

This L/C is subject to and incorporates by reference: (a) the International Standby Practices 98 (“ISP 98”); and
(b) to the extent not inconsistent with ISP 98, Article 5 of the Uniform Commercial Code of the State of New York. 
  

	
	Very truly yours,
	
	[Issuer Signature]

  
 E-2

 ATTACHMENT 1 TO EXHIBIT E 

FORM OF SIGHT DRAFT 
 [BENEFICIARY LETTERHEAD] 
 TO: 

[Name and Address of Issuer] 

SIGHT DRAFT 
 AT SIGHT,
pay to the Order of                     , the sum of
                     United States Dollars ($            ). Drawn under [Issuer] Letter
of Credit No.                      dated
                    . 
 [Issuer is hereby
directed to pay the proceeds of this Sight Draft solely to the following account:                    .] 

[Name and signature block, with signature or purported signature of Beneficiary] 

 

			
	Date:	 	 

  
 E-1-1

 ATTACHMENT 2 TO EXHIBIT E 

FORM OF TRANSFER NOTICE 
 [BENEFICIARY LETTERHEAD] 
 TO: 

[Name and Address of Issuer] (the “Issuer”) 
 TRANSFER NOTICE 
 By signing below, the undersigned, Beneficiary (the
“Beneficiary”) under Issuer’s Letter of Credit No.                      dated
                     (the “L/C”), transfers the L/C to the following transferee (the “Transferee”): 

[Transferee Name and Address] 
 The original
L/C is enclosed. Beneficiary directs Issuer to reissue or amend the L/C in favor of Transferee as Beneficiary. Beneficiary represents and warrants that Beneficiary has not transferred, assigned, or encumbered the L/C or any interest in the L/C,
which transfer, assignment, or encumbrance remains in effect. 
 [Name and signature block, with signature or purported signature of
Beneficiary] 
  

			
	Date:	 	 

  
 E-2-1

 EXHIBIT F 
 RULES AND REGULATIONS 
 NOTHING IN THESE RULES AND REGULATIONS
(“RULES AND REGULATIONS”) SHALL SUPPLANT ANY PROVISION OF THE LEASE. IN THE EVENT OF A CONFLICT OR INCONSISTENCY BETWEEN THESE RULES AND REGULATIONS AND THE LEASE, THE LEASE SHALL PREVAIL. 

1. Neither Tenant nor Tenant’s employees, agents, contractors or invitees shall encumber or obstruct the common entrances, lobbies, elevators,
sidewalks and stairways of the Building(s) or the Project or use them for any purposes other than ingress or egress to and from the Building(s) or the Project. 
 2. Except as specifically provided in the Lease, no sign, placard, picture, advertisement, name or notice shall be installed or displayed on any part of the outside of the Premises or the Building(s)
without Landlord’s prior written consent. Landlord shall have the right to remove, at Tenant’s sole cost and expense and without notice, any sign installed or displayed in violation of this rule. 

3. If Landlord objects in writing to any curtains, blinds, shades, screens, hanging plants or other objects attached to or used in connection with any
window or door of the Premises or placed on any windowsill, and (a) such window, door or windowsill is visible from the exterior of the Premises and (b) such curtain, blind, shade, screen, hanging plant or other object is not included in
plans approved by Landlord, then Tenant shall promptly remove said curtains, blinds, shades, screens, hanging plants or similar objects at its sole cost and expense. 
 4. No deliveries shall be made that impede or interfere with other tenants in or the operation of the Project. 
 5. Tenant shall not place a load upon any floor of the Premises that exceeds the load per square foot that (a) such floor was designed to carry or (b) is allowed by Applicable Laws. Fixtures and
equipment that cause noises or vibrations that may be transmitted to the structure of the Building(s) to such a degree as to be objectionable to other tenants shall be placed and maintained by Tenant, at Tenant’s sole cost and expense, on
vibration eliminators or other devices sufficient to eliminate such noises and vibrations to levels reasonably acceptable to Landlord and the affected tenants of the Project. 
 6. Tenant shall not use any method of heating or air conditioning other than that present at the Project and serving the Premises as of the Execution Date. 

7. Tenant shall not install any radio, television or other antennae; cell or other communications equipment; or other devices on the roof or exterior
walls of the Premises except in accordance with the Lease. Tenant shall not interfere with radio, television or other digital or electronic communications at the Project or elsewhere. 
 8. Canvassing, peddling, soliciting and distributing handbills or any other written material within, on or around the Project (other than within the Premises) are prohibited. Tenant shall cooperate with
Landlord to prevent such activities by Tenant or its employees, agents, contractors and invitees. 

  
 F-1

 9. Tenant shall store all of its trash, garbage and Hazardous Materials within its Premises or in
receptacles designated by Landlord outside of the Premises. Tenant shall not place in any such receptacle any material that cannot be disposed of in the ordinary and customary manner of trash, garbage and Hazardous Materials disposal. Any Hazardous
Materials transported through Common Areas shall be held in secondary containment devices. 
 10. The Premises shall not be used for lodging or
for any improper, immoral or objectionable purpose. No cooking shall be done or permitted in the Premises; provided, however, that Tenant may use (a) equipment approved in accordance with the requirements of insurance policies that
Landlord or Tenant is required to purchase and maintain pursuant to the Lease for brewing coffee, tea, hot chocolate and similar beverages, (b) microwave ovens for employees’ use and (c) equipment shown on Tenant Improvement plans
approved by Landlord; provided, further, that any such equipment and microwave ovens are used in accordance with Applicable Laws. 
 11.
Tenant shall not, without Landlord’s prior written consent, use the name of the Project, if any, in connection with or in promoting or advertising Tenant’s business except as Tenant’s address. 

12. Tenant shall comply with all safety, fire protection and evacuation procedures and regulations established by Landlord or any Governmental Authority.

 13. Tenant assumes any and all responsibility for protecting the Premises from theft, robbery and pilferage, which responsibility includes
keeping doors locked and other means of entry to the Premises closed. 
 14. Tenant shall furnish Landlord with copies of keys, pass cards or
similar devices for locks to the Premises. 
 15. Tenant shall cooperate and participate in all reasonable security programs affecting the
Premises. 
 16. Tenant shall not permit any animals in the Project, other than for guide animals or for use in laboratory experiments.

 17. Bicycles shall not be taken into the Building(s) except into areas designated by Landlord. 

18. The water and wash closets and other plumbing fixtures shall not be used for any purposes other than those for which they were constructed, and no
sweepings, rubbish, rags or other substances shall be deposited therein. 
 19. Discharge of industrial sewage shall only be permitted if
Tenant, at its sole expense, first obtains all necessary permits and licenses therefor from all applicable Governmental Authorities. 
 20.
Smoking is prohibited at the Project. 
 21. The Project’s hours of operation are currently 24 hours a day, seven days a week. 

  
 F-2

 22. Tenant shall comply with all orders, requirements and conditions now or hereafter imposed by Applicable
Laws or Landlord (“Waste Regulations”) regarding the collection, sorting, separation and recycling of waste products, garbage, refuse and trash generated by Tenant (collectively, “Waste Products”), including
(without limitation) the separation of Waste Products into receptacles reasonably approved by Landlord and the removal of such receptacles in accordance with any collection schedules prescribed by Waste Regulations. 

23. Tenant, at Tenant’s sole cost and expense, shall cause the Premises to be exterminated on a monthly basis to Landlord’s reasonable
satisfaction and shall cause all portions of the Premises used for the storage, preparation, service or consumption of food or beverages to be cleaned daily in a manner reasonably satisfactory to Landlord, and to be treated against infestation by
insects, rodents and other vermin and pests whenever there is evidence of any infestation. Tenant shall not permit any person to enter the Premises or the Project for the purpose of providing such extermination services, unless such persons have
been approved by Landlord. If requested by Landlord, Tenant shall, at Tenant’s sole cost and expense, store any refuse generated in the Premises by the consumption of food or beverages in a cold box or similar facility. 

Landlord may waive any one or more of these Rules and Regulations for the benefit of Tenant or any other tenant, but no such waiver by
Landlord shall be construed as a waiver of such Rules and Regulations in favor of Tenant or any other tenant, nor prevent Landlord from thereafter enforcing any such Rules and Regulations against any or all of the tenants of the Project, including
Tenant. These Rules and Regulations are in addition to, and shall not be construed to in any way modify or amend, in whole or in part, the terms covenants, agreements and conditions of the Lease. Landlord reserves the right to make such other and
reasonable rules and regulations as, in its judgment, may from time to time be needed for safety and security, the care and cleanliness of the Project, or the preservation of good order therein; provided, however, that Tenant shall not be
obligated to adhere to such additional rules or regulations until Landlord has provided Tenant with written notice thereof. Tenant agrees to abide by these Rules and Regulations and any additional rules and regulations issued or adopted by Landlord.
Tenant shall be responsible for the observance of these Rules and Regulations by Tenant’s employees, agents, contractors and invitees. 

  
 F-3

 EXHIBIT G 
 [Intentionally omitted] 

  
 G-1

 EXHIBIT H 
 TENANT’S PERSONAL PROPERTY 

  
 H-1

 EXHIBIT I 
 FORM OF ESTOPPEL CERTIFICATE 
  

	To:	BMR-325 VASSAR STREET LLC 

 17190
Bernardo Center Drive 
 San Diego, California 92128 
 Attention: Vice President, Real Estate Counsel 
 BioMed Realty, L.P. 

17190 Bernardo Center Drive 
 San Diego, California 92128 
  

	Re:	[PREMISES ADDRESS] (the “Premises”) at 325 Vassar Street, Cambridge, Massachusetts (the “Property”) 

The undersigned tenant (“Tenant”) hereby certifies to you as follows: 

1. Tenant is a tenant at the Property under a lease (the “Lease”) for the Premises dated as of July 20, 2011. The
Lease has not been cancelled, modified, assigned, extended or amended [except as follows: [                    ]], and there are no other agreements,
written or oral, affecting or relating to Tenant’s lease of the Premises or any other space at the Property. The lease term expires on [            ], 20[    ].

 2. Tenant took possession of the Premises, currently consisting of [    ] square feet, on
[            ], 20[    ], and commenced to pay rent on [            ], 20[    ]. Tenant
has full possession of the Premises, has not assigned the Lease or sublet any part of the Premises, and does not hold the Premises under an assignment or sublease[, except as follows:
[            ]]. 
 3. All base rent, rent escalations and
additional rent under the Lease have been paid through [            ], 20[    ]. There is no prepaid rent[, except
$[            ]][, and the amount of security deposit is $[            ] [in cash][OR][in the form of a letter of credit]].
Tenant currently has no right to any future rent abatement under the Lease. 
 4. Base rent is currently payable in the amount
of $[            ] per month. 
 5. Tenant is currently paying
estimated payments of additional rent of $[            ] per month on account of real estate taxes, insurance, management fees and common area maintenance expenses. 

6. All work to be performed for Tenant under the Lease has been performed as required under the Lease and has been accepted by Tenant[,
except [            ]], and all allowances to be paid to Tenant, including allowances for tenant improvements, moving expenses or other items, have been paid. 

7. The Lease is in full force and effect, free from default and free from any event that could become a default under the Lease, and
Tenant has no claims against the landlord or offsets or defenses against rent, and there are no disputes with the landlord. Tenant has received no notice of prior sale, transfer, assignment, hypothecation or pledge of the Lease or of the rents
payable thereunder[, except [            ]]. 

  
 I-1

 8. [Tenant has the following expansion rights or options for the Property:
[            ].][OR][Tenant has no rights or options to purchase the Property.] 
 9. The undersigned has executed this Estoppel Certificate with the knowledge and understanding that [INSERT NAME OF LANDLORD, PURCHASER OR LENDER, AS APPROPRIATE] or its assignee is acquiring the Property
in reliance on this certificate and that the undersigned shall be bound by this certificate. The statements contained herein may be relied upon by [INSERT NAME OF PURCHASER OR LENDER, AS APPROPRIATE], [LANDLORD], BioMed Realty, L.P., BioMed Realty
Trust, Inc., and any [other] mortgagee of the Property and their respective successors and assigns. 
 Any capitalized terms not
defined herein shall have the respective meanings given in the Lease. 
 Dated this [    ] day of
[            ], 20[    ]. 
  

			
	BIND BIOSCIENCES, INC.,
	a Delaware corporation
		
	By:	 	  

	Name:	 	  

	Title:	 	  

  
 I-2EX-4.6

 Exhibit 4.6 
 FOURTH AMENDED AND RESTATED 
 VOTING AGREEMENT 

This Fourth Amended and Restated Voting Agreement dated as of November 7, 2011 (this “Agreement”) is made by and
among BIND Biosciences, Inc., a Delaware corporation (the “Company”); the persons and entities listed on Schedule A (each a “Purchaser” and collectively, the “Purchasers”); Omid
Farokhzad, Paul Goldenheim and Robert S. Langer, Jr. (each, a “Founder,” and collectively, the “Founders”); the persons listed on Schedule B (collectively, the “Executive
Officers”); and the persons listed on Schedule C (the “Other Stockholders”). The Purchasers, the Founders, the Executive Officers and the Other Stockholders are (together with and any other persons or entities
that become parties to this Agreement after the date hereof in accordance with Section 12.8 or 12.9 hereof) referred to in this Agreement individually as a “Stockholder” and collectively as the
“Stockholders.” 
 WHEREAS, the Company, the Founders, the Executive Officers, the Other Stockholders and
certain of the Purchasers (the “Prior Purchasers”), are parties to a Third Amended and Restated Voting Agreement dated as of June 14, 2010 (the “Former Voting Agreement”); 

WHEREAS, the Company and certain of the Purchasers (the “Series D Investors”) are parties to the Series D Preferred
Stock Investment Agreement and Series BRN Preferred Stock Investment Agreement dated as of October 27, 2011 (the “Purchase Agreement”) pursuant to which the Series D Investors have agreed to purchase shares of the
Company’s Series D Convertible Preferred Stock, $0.0001 par value per share (the “Series D Preferred Stock”) and shares of the Company’s Series BRN Convertible Preferred Stock, $0.0001 par value per share (the
“Series BRN Preferred Stock”); 
 WHEREAS, the Series D Investors have made it a condition precedent to their
purchase of shares of Series D Preferred Stock and Series BRN Preferred Stock pursuant to the Purchase Agreement that the Former Voting Agreement be amended and restated in its entirety as set forth herein; and 

WHEREAS, the Company and the undersigned Prior Purchasers and Founders have the power to amend and restate the Former Voting Agreement as
set forth herein pursuant to Section 9.5 thereof, such amendment and restatement to be binding on all parties to the Former Voting Agreement; 
 NOW, THEREFORE, in consideration of the premises and the mutual covenants set forth herein, the Former Voting Agreement is hereby amended and restated in its entirety as set forth herein. 

1. Voting of Shares. 
 1.1 Board of Directors. In any and all elections of directors of the Company (whether at a meeting or by written consent in lieu of a meeting), each Stockholder shall vote or cause to be voted all
Shares (as defined in Section 2) owned by him or it, or over which he or it has voting control, and otherwise use his or its respective best efforts, so as to: 
 (a) fix the number of directors of the Company at ten (10); 

 (b) elect the following persons as directors: (i) one person designated by Polaris
Venture Partners IV, L.P. or an Affiliated Entity (as defined in Section 8.2) thereof (“Polaris”), who shall initially be Amir Nashat (the “Polaris Director”); (ii) one person designated by Flagship
Ventures Fund 2004, L.P. or an Affiliated Entity thereof (“Flagship”), who shall initially be Noubar Afeyan (the “Flagship Director”); (iii) one person designated by ARCH Venture Fund VII, L.P.
(“ARCH”) or an Affiliated Entity thereof (the “ARCH Director”), which seat shall initially be vacant; (iv) one person designated by DHK Investments, LLC (“DHK”), who may only be David H.
Koch (“Koch”); (v) two directors each designated by a majority of the Founders, who shall initially be Omid Farokhzad and Robert S. Langer, Jr.; (vi) the person who shall serve from time to time as the chief
executive officer of the Company, initially Scott Minick; (vii) one person designated by RUSNANO, an open joint stock company organized and existing under the laws of the Russian Federation (“RUSNANO”), who must be either a
member of RUSNANO’s executive board or an experienced global pharmaceutical executive with predefined qualification requirements consistent with those applied in relation to the other members of the Board of Directors and who shall initially be
Yuriy Udaltsov (the “RUSNANO Director”) and (viii) two persons not otherwise Affiliates of the Company and designated by a majority of the other directors (the “Outside Directors”), one of whom shall initially
be Peter Barton Hutt, and the other of which seats shall initially be vacant; and 
 (c) remove any director at the request of
the party or parties entitled to designate such director. 
 For avoidance of doubt, DHK shall not be obligated to designate
Koch for election as a director. For so long as DHK shall have a right hereunder to designate Koch for election as a director, in the event that DHK shall not have so designated Koch for election, the seat on the Board of Directors of the Company
(the “Board of Directors”) that would otherwise be occupied by Koch shall remain vacant, and neither the Company nor any Stockholder shall take any action to fill such vacancy without the written authorization of DHK. 

For avoidance of doubt, ARCH shall not be obligated to designate a director. For so long as ARCH shall have a right hereunder to
designate a director, in the event that ARCH shall not have so designated any individual, the Board of Directors seat that would otherwise be occupied by an ARCH Director shall remain vacant, and neither the Company nor any Stockholder shall take
any action to fill such vacancy without the written authorization of ARCH. 
 Each director appointed pursuant to
Section 1.1(b)(i), Section 1.1(b)(ii), Section 1.1(b)(iii), Section 1.1(b)(iv) or Section 1.1(b)(vii) shall be referred to herein as a “Preferred Director” and collectively
as the “Preferred Directors.” 
 1.2 Observer Rights. 

(a) As long as NanoDimension L.P. (“NanoDimension”) holds not less than 500,000 shares of Common Stock (as defined
below) (including shares of Common Stock issuable upon conversion of Preferred Stock (as defined below)) subject to appropriate 

  
 2 

 
adjustment for all stock splits, dividends, combinations, recapitalizations and similar events, the Company shall (i) invite a representative of NanoDimension (the “NanoDimension
Observer”) to attend all meetings of its Board of Directors in a nonvoting observer capacity and (ii) shall give such representative copies of all notices, minutes, consents, and other materials that it provides to its directors;
provided, however, that any such representative shall agree in writing to hold in confidence and trust and to act in a fiduciary manner with respect to all information so provided; and provided further, that the Company reserves the right to
withhold any information and to exclude such representative from any meeting or portion thereof if access to such information or attendance at such meeting could adversely affect the attorney-client privilege between the Company and its counsel or
result in disclosure of trade secrets or a conflict of interest, or if such Stockholder or its representative is a competitor of the Company. 
 (b) If at any time prior to the termination of this Section 1, Polaris, Flagship, ARCH, DHK or RUSNANO shall (i) not have a designation right pursuant to Section 1.1 (or, in
the case of DHK, shall not have or shall not then be exercising its designation right pursuant to Section 1.1), and (ii) hold not less than 500,000 shares (or, in the case of DHK, 165,000 shares) of Common Stock (including shares of
Common Stock issuable upon conversion of Preferred Stock), subject to appropriate adjustment for all stock splits, dividends, combinations, recapitalizations and similar events, the Company shall (A) invite a representative of such Stockholder
to attend all meetings of its Board of Directors in a nonvoting observer capacity and (B) give such representative copies of all notices, minutes, consents, and other materials that it provides to its directors; provided, however, that any such
representative shall agree in writing to hold in confidence and trust and to act in a fiduciary manner with respect to all information so provided; and provided further, that the Company reserves the right to withhold any information and to exclude
such representative from any meeting or portion thereof if access to such information or attendance at such meeting could adversely affect the attorney-client privilege between the Company and its counsel or result in disclosure of trade secrets or
a conflict of interest, or if such Stockholder or its representative is a competitor of the Company. 
 (c) As long as Peter
Doelger (“Doelger”) and Dimitris J. Bertsimas (“Bertismas”) collectively hold not less than 165,000 shares of Common Stock (including shares of Common Stock issuable upon conversion of Preferred Stock) subject
to appropriate adjustment for all stock splits, dividends, combinations, recapitalizations and similar events, the Company shall (i) invite a representative of such Stockholders to attend all meetings of its Board of Directors in a nonvoting
observer capacity, provided that such representative may only be Peter Doelger, and (ii) shall give such representative copies of all notices, minutes, consents, and other materials that it provides to its directors; provided, however, that any
such representative shall agree in writing to hold in confidence and trust and to act in a fiduciary manner with respect to all information so provided; and provided further, that the Company reserves the right to withhold any information and to
exclude such representative from any meeting or portion thereof if access to such information or attendance at such meeting could adversely affect the attorney­ client privilege between the Company and its counsel or result in disclosure of
trade secrets or a conflict of interest, or if such Stockholder or its representative is a competitor of the Company. 
 (d) As
long as Endeavour II L.P. (“Endeavour”), Gerald W. Blakeley, Jr. and Gerald W. Blakeley, III (collectively, “Blakeley”) and D2 Investment LLC (“D2 Investment”) collectively hold
not less than 165,000 shares of Common Stock (including 

  
 3 

 
shares of Common Stock issuable upon conversion of Preferred Stock) subject to appropriate adjustment for all stock splits, dividends, combinations, recapitalizations and similar events, the
Company shall (i) invite a representative of Endeavour, Blakeley or D2 Investment (such representative to be designated for each meeting by Endeavour, Gerald W. Blakeley, III or D2 Investment in a rotating fashion) to attend each
meeting of its Board of Directors in a nonvoting observer capacity, and (ii) shall give Gerald W. Blakeley, Jr., Gerald W. Blakeley, III and the representatives of each of Endeavour and D2 Investment copies of all notices,
minutes, consents, and other materials that it provides to its directors; provided, however, that each such person shall agree in writing to hold in confidence and trust and to act in a fiduciary manner with respect to all information so provided;
and provided further, that the Company reserves the right to withhold any information and to exclude any such person from any meeting or portion thereof if access to such information or attendance at such meeting could adversely affect the
attorney-client privilege between the Company and its counsel or result in disclosure of trade secrets or a conflict of interest, or if such Stockholder or its representative is a competitor of the Company. 

1.3 CEO Director. In the event that the person serving pursuant to Section 1.1(b)(vi) above ceases to be Chief
Executive Officer of the Company, such person agrees to resign from the Board of Directors on the date such person ceases to be the Chief Executive Officer. 
 1.4 Compensation Committee. The Board of Directors shall appoint a Compensation Committee consisting of the Polaris Director, the Flagship Director, the ARCH Director, and one Outside Director to
determine compensation for the officers and directors of the Company, including option grants or other equity compensation. 

1.5 Voting Agreement Regarding Certain Other Matters. With respect to any action or failure to act which would require the
consent, affirmative vote, waiver, approval or execution of any instrument or agreement by stockholders or Purchasers holding a minimum specified portion of the outstanding shares of the Company’s Series C Convertible Preferred Stock, $0.0001
par value per share (the “Series C Preferred Stock”) (whether such requirement is set forth in the Certificate of Incorporation or the By-laws of the Company, in one or more agreements to which the Purchasers are parties, under
applicable law or otherwise) (each such specified portion, a “Series C Voting Threshold”), each of Doelger, the Doelger Family 2006 Trust FBO Emily M. Doelger, the Doelger Family 2006 Trust FBO Matthew Doelger and the Hee-Jean
Kim 2007 Trust (collectively, the “Doelger Group”) and Bertsimas agrees as follows: (i) with respect to any such action or failure to act for which affirmative votes, consents, waivers, approvals or executed instruments or
agreements, as the case may be, have been duly provided by Purchasers (excluding the Doelger Group and Bertsimas) holding such number of shares of capital stock as would, but for the fact that the shares of capital stock issued to the Doelger Group
and Bertsimas are issued and outstanding and held by any member of the Doelger Group or Bertsimas (and assuming that such shares of capital stock would not otherwise be outstanding), equal or exceed the applicable Series C Voting Threshold (each, a
“Trigger Amount”), each member of the Doelger Group and Bertsimas hereby agrees to vote its shares in favor of, or execute such consents, waivers, approvals, instruments or agreements, as applicable, as shall be necessary to permit
or effect, such action or failure to act, as the case may be, and (ii) with respect to any such action or failure to act for which the affirmative vote, waiver or approval has not been obtained from Purchasers (excluding the Doelger Group and
Bertsimas) 

  
 4 

 
holding the applicable Trigger Amount, each member of the Doelger Group and Bertsimas hereby agrees to refrain from voting its shares in favor of, and refrain from executing any consents,
waivers, approvals, instruments or agreements, as applicable, that would permit or effect such action or failure to act, as the case maybe. 
 1.6 Board of Directors and Internal Audit Commission of the Project Company. In any and all elections of directors or internal audit commission members of BIND (RUS) LLC, a controlled subsidiary of
the Company (the “Project Company”), whether at a meeting or by written consent in lieu of a meeting, the Company, as the controlling participant of the Project Company, shall vote or cause to be voted all shares of capital stock of
the Project Company owned by it, or over which it has voting control, so as to: 
 (a) fix the number of directors of the
Project Company at five (5). 
 (b) elect the following persons as directors of the Project Company: 

(i) prior to the purchase by a Co-Investor (as defined in the Purchase Agreement) of shares of Series BRN Preferred pursuant to the
Purchase Agreement, two (2) directors designated by RUSNANO, who shall initially be Vasiliy Kostyanovskiy and Leysan Shaydullina; 
 (ii) from and after the purchase by a Co-Investor of shares of Series BRN Preferred pursuant to the Purchase Agreement, one (1) director designated by RUSNANO and, for so long as a Co-Investor holds
and has sole beneficial ownership of all of the shares of Series BRN Preferred Stock purchased by it under the Purchase Agreement, one (1) director designated by the Co-Investor; and 

(iii) three (3) directors designated by the Board of Directors, who shall initially be Jeff Hrkach, Scott Minick and Robert Rosen.

 (c) appoint or cause to be appointed one of the directors designated pursuant to Section 1.6(b)(iii) as the
Chairperson of each board meeting of the Project Company. 
 (d) appoint or cause to be appointed one of the directors
designated by RUSNANO pursuant to Sections 1.6(b)(i) or 1.6(b)(ii) as the Secretary of each board meeting of the Project Company at which an action requiring the unanimous consent of the directors of the Project Company is taken.

 (e) appoint or cause to be appointed to the internal audit commission of the Project Company one (1) nominee designated
by RUSNANO, provided that such nominee shall not be a member of the board of directors of the Project Company. 
 (f) appoint
or cause to be appointed to the internal audit commission of the Project Company two (2) nominees designated by the Board of Directors, provided that such nominees shall not be members of the board of directors of the Project Company.

 (g) remove any director of the Project Company at the request of the party or parties entitled to designate such director
pursuant to Section 1.6(b) above. 

  
 5 

 (h) Notwithstanding anything to the contrary herein, this Section 1.6 shall
terminate and be of no further force and effect on the earliest date on which RUSNANO (or a controlled affiliate that is a permitted transferee pursuant to Section 8.3) no longer holds and has sole beneficial ownership of all of the
shares of Series BRN Preferred Stock purchased by it under the Purchase Agreement, whether as a result of any transfer, sale, conversion or redemption or otherwise. 
 2. Shares. “Shares” shall mean and include any and all shares of (i) the Company’s common stock, $0.0001 par value per share (the “Common Stock”),
(ii) the Company’s Series A Convertible Preferred Stock, $0.0001 par value per share (the “Series A Preferred Stock”), the Company’s Series B Convertible Preferred Stock, $0.0001 par value per share (the
“Series B Preferred Stock”), the Series C Preferred Stock, the Company’s Series C-1 Convertible Preferred Stock, $0.0001 par value per share (the “Series C-1 Preferred Stock”), and the Series D Preferred Stock
(collectively, the “Preferred Stock”), (iii) the Series BRN Preferred Stock and (iv) any other series and classes of capital stock of the Company, by whatever name called, which carry voting rights (including voting rights
which arise by reason of default) and shall include any such shares now owned or subsequently acquired by a Stockholder, however acquired, including in connection with stock splits, stock dividends, and the exercise of options or conversion or
exchange of convertible securities. 
 3. Drag-Along Right. 

3.1 Definitions. A “Sale of the Company” shall mean either: (a) a transaction or series of related
transactions in which a person, or a group of related persons, acquires from stockholders of the Company shares representing more than fifty percent (50%) of the outstanding voting power of the Company (a “Stock Sale”); or
(b) a transaction or series of related transactions regarded as a liquidation, dissolution or winding up of the affairs of the Company under Section 3.2 of Article Fourth of the Company’s Certificate of Incorporation, as may be
amended from time to time (the “Company Charter” and such transaction or series of related transactions, a “Liquidation Event”)). 
 3.2 Actions to be Taken. In the event that: (i) the holders of at least sixty percent (60%) of the shares of Common Stock then issued or issuable upon conversion of the shares of
Preferred Stock, voting together as a single class, and (ii) the holders of at least sixty percent (60%) of the then outstanding shares of Common Stock (collectively, the “Selling Stockholders”) approve a Sale of the
Company in writing, specifying that this Section 3 shall apply to such transaction, then each Stockholder hereby agrees: 
 (a) if such transaction requires stockholder approval, with respect to all Shares that such Stockholder owns or over which such Stockholder otherwise exercises voting power, to vote (in person, by proxy
or by action by written consent, as applicable) all such Shares in favor of, and adopt, such Sale of the Company (together with any related amendment to the Company Charter required in order to implement such Sale of the Company) and to vote in
opposition to any and all other proposals that could reasonably be expected to delay or impair the ability of the Company to consummate such Sale of the Company; 

  
 6 

 (b) if such transaction is a Stock Sale, to sell the same proportion of Shares beneficially
held by such Stockholder as is being sold by the Selling Stockholders to the person to whom the Selling Stockholders propose to sell their Shares, and, except as permitted in Section 3.3 below, on the same terms and conditions as the
Selling Stockholders; 
 (c) to execute and deliver all related documentation and take such other action in support of the Sale
of the Company as shall reasonably be requested by the Company or the Selling Stockholders in order to carry out the terms and provision of this Section 3, including without limitation executing and delivering instruments of conveyance
and transfer, and any purchase agreement, merger agreement, indemnity agreement, escrow agreement, consent, waiver, governmental filing, share certificates duly endorsed for transfer (free and clear of impermissible liens, claims and encumbrances)
and any similar or related documents; 
 (d) not to deposit, and to cause their Affiliated Entities not to deposit, except as
provided in this Agreement, any Shares owned by such party or Affiliate in a voting trust or subject any Shares to any arrangement or agreement with respect to the voting of such Shares, unless specifically requested to do so by the acquiror in
connection with the Sale of the Company; 
 (e) to refrain from exercising any dissenters’ rights or rights of appraisal
under applicable law at any time with respect to such Sale of the Company; and 
 (f) if the consideration to be paid in
exchange for the Shares pursuant to this Section 3 includes any securities and due receipt thereof by any Stockholder would require under applicable law (i) the registration or qualification of such securities or of any person as a
broker or dealer or agent with respect to such securities or (ii) the provision to any Stockholder of any information other than such information as a prudent issuer would generally furnish in an offering made solely to “accredited
investors” as defined in Regulation D promulgated under the Securities Act of 1933, as amended (the “Act”), the Company may cause to be paid to any such Stockholder in lieu thereof, against surrender of the Shares which
would have otherwise been sold by such Stockholder, an amount in cash equal to the fair value (as determined in good faith by the Company) of the securities which such Stockholder would otherwise receive as of the date of the issuance of such
securities in exchange for the Shares. 
 3.3 Exceptions. Notwithstanding the foregoing, a Stockholder will not be
required to comply with Section 3.2 above in connection with any proposed Sale of the Company (the “Proposed Sale”) unless: 
 (a) any representations and warranties to be made by such Stockholder in connection with the Proposed Sale are limited to representations and warranties related to authority, ownership and the ability to
convey title to such Shares, including but not limited to representations and warranties that (i) the Stockholder holds all right, title and interest in and to the Shares such Stockholder purports to hold, free and clear of all liens and
encumbrances, (ii) the obligations of the Stockholder in connection with the transaction have been duly authorized, if applicable, (iii) the documents to be entered into by the Stockholder have been duly executed by the Stockholder and
delivered to the acquirer and are enforceable against the 

  
 7 

 
Stockholder in accordance with their respective terms and (iv) neither the execution and delivery of documents to be entered into in connection with the transaction, nor the performance of
the Stockholder’s obligations thereunder, will cause a breach or violation of the terms of any agreement, law or judgment, order or decree of any court or governmental agency; 

(b) the Stockholder shall not be liable for the inaccuracy of any representation or warranty made by any other person in connection with
the Proposed Sale, other than the Company (except to the extent that funds may be paid out of an escrow established to cover breach of representations, warranties and covenants of the Company as well as breach by any stockholder of any of identical
representations, warranties and covenants provided by all stockholders); 
 (c) the liability for indemnification, if any, of
such Stockholder in the Proposed Sale and for the inaccuracy of any representations and warranties made by the Company in connection with such Proposed Sale, is several and not joint with any other person or entity (except to the extent that funds
may be paid out of an escrow established to cover breach of representations, warranties and covenants of the Company as well as breach by any stockholder of any of identical representations, warranties and covenants provided by all stockholders),
and is pro rata in proportion to the amount of consideration paid to such Stockholder in connection with such Proposed Sale (in accordance with the provisions of the Company Charter); 

(d) liability shall be limited to such Stockholder’s applicable share (determined based on the respective proceeds payable to each
Stockholder in connection with such Proposed Sale in accordance with the provisions of the Company Charter) of a negotiated aggregate indemnification amount that applies equally to all Stockholders but that in no event exceeds the amount of
consideration otherwise payable to such Stockholder in connection with such Proposed Sale, except with respect to claims related to fraud by such Stockholder, the liability for which need not be limited as to such Stockholder; 

(e) upon the consummation of the Proposed Sale, (i) each holder of each class or series of the Company’s stock will receive
the same form of consideration for their shares of such class or series as is received by other holders in respect of their shares of such same class or series of stock, (ii) each holder of a series of Preferred Stock will receive the same
amount of consideration per share of such series of Preferred Stock as is received by other holders in respect of their shares of such same series, (iii) each holder of Series BRN Preferred Stock will receive the same amount of consideration
per share of such series as is received by other holders in respect of their shares of such same series, (iv) each holder of Common Stock will receive the same amount of consideration per share of Common Stock as is received by other holders in
respect of their shares of Common Stock, and (v) the aggregate consideration receivable by all holders of the Preferred Stock and Common Stock shall be allocated among the holders of Preferred Stock and Common Stock on the basis of the relative
liquidation preferences to which the holders of each respective series of Preferred Stock and the holders of Common Stock are entitled in a liquidation, dissolution or winding up of the affairs of the Company (assuming for this purpose that the
Proposed Sale is a liquidation, dissolution or winding up of the affairs of the Company) in accordance with the Company Charter in effect immediately prior to the Proposed Sale; and 

  
 8 

 (f) subject to clause (e) above, requiring the same form of consideration to be
available to the holders of any single class or series of capital stock, and if any holders of any capital stock of the Company are given an option as to the form and amount of consideration to be received as a result of the Proposed Sale, all
holders of such capital stock will be given the same option. 
 4. Manner of Voting. The voting of Shares pursuant to
this Agreement may be effected in person, by proxy, by written consent or in any other manner permitted by applicable law. 
 5.
Termination. Sections 1, 3 and 4 of this Agreement shall terminate in their entirety on the earliest to occur of (i) the closing of the Company’s first public offering pursuant to a registration statement under
the Act (an “IPO”), (ii) the closing of a Sale of the Company, or (iii) such time as less than 2,200,000 shares of Preferred Stock remain outstanding, subject to appropriate adjustment for all stock splits, dividends,
combinations, recapitalizations and similar events. 
 6. No Revocation. The voting agreements contained herein are
coupled with an interest and may not be revoked, except by an amendment, modification or termination effected in accordance with Section 12.5 hereof. Nothing in this Section 6 shall be construed as limiting the provisions of
Section 5 or 12.5 hereof. 
 7. Restrictive Legend. All certificates representing Shares owned or
hereafter acquired by the Stockholders or any transferee of the Stockholders bound by this Agreement shall have affixed thereto a legend substantially in the following form: 
 THE SECURITIES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO A VOTING AGREEMENT, AS AMENDED FROM TIME TO TIME, BY AND AMONG THE REGISTERED OWNER OF THIS CERTIFICATE, THE COMPANY AND CERTAIN OTHER
STOCKHOLDERS OF THE COMPANY. THE COMPANY WILL FURNISH A COPY OF THIS AGREEMENT TO THE HOLDER HEREOF WITHOUT CHARGE UPON WRITTEN REQUEST. 
 8. Transfers of Rights. 
 8.1 Any transferee to whom Shares are transferred
by a Stockholder, whether voluntarily or by operation of law, shall be bound by the obligations imposed upon the transferor under this Agreement, to the same extent as if such transferee were a Stockholder hereunder, and no Stockholder shall
transfer any Shares unless the transferee agrees in writing to be bound by this Agreement. 
 8.2 Notwithstanding anything to
the contrary herein, any Purchaser (other than RUSNANO) which is a partnership, limited liability company or joint stock company may transfer rights granted to such Purchaser hereunder to any partner, affiliated fund or member thereof, or to any
entity or person that controls, or is controlled by, or is under common control with, such Purchaser (an “Affiliate” or “Affiliated Entity”) to which Shares are transferred and which delivers to the Company a
written instrument in accordance with Section 8.1. In the event 

  
 9 

 
of such transfer, such Affiliated Entity shall be deemed a Purchaser and may again transfer such rights to any other person or entity that acquires Shares in accordance with, and subject to, the
provisions of this Section 8. 
 8.3 Notwithstanding anything to the contrary herein, RUSNANO may transfer all, but
not less than all, rights granted to RUSNANO hereunder to any entity that is controlled by RUSNANO, an open joint stock company organized and existing under the laws of the Russian Federation, to which all Shares held by RUSNANO are transferred and
which delivers to the Company a written instrument in accordance with Section 8.1; in the event of such transfer, such transferee shall be deemed a “Purchaser” and “RUSNANO” hereunder and may again transfer such
rights to any other entity controlled by RUSNANO, an open joint stock company organized and existing under the laws of the Russian Federation, that acquires all such Shares and rights in accordance with, and subject to, the provisions of this
Section 8. 
 9. Reimbursement of Expenses. The Company shall pay the reasonable out-of-pocket expenses of
all the directors (other than directors who are employees of the Company, who shall be reimbursed in accordance with the Company’s employee travel policies) and any Board of Directors observers appointed pursuant to Section 1.2 in
attending meetings of the Board of Directors and committees thereof (including travel, room and board). 
 10. Call
Option. Provided that there is no unremedied KPI Failure (as defined in the Purchase Agreement) with respect to any Additional Closing (as defined in the Purchase Agreement), the Company shall have the right to require each holder of outstanding
shares of Series BRN Preferred Stock to sell to the Company all (but not less than all) of its shares of Series BRN Preferred Stock (the “Call Option”) under the following terms and conditions: 

10.1 At any time on or after the fourth (4th) anniversary of the Initial Closing Date (as defined in the Purchase Agreement), the Company shall have the right
to exercise the Call Option in the manner set forth in Section 10.3 below at a per share purchase price equal to an amount that would yield a twenty percent (20%) internal rate of return on the original purchase price paid by such
holder for the shares of Series BRN Preferred Stock subject to the Call Option (the “IRR Exercise Price”). For purposes hereof, “internal rate of return” means the discount rate at which the net present value of the
Original Issue Price (as defined in the Company Charter) of the Series BRN Preferred Stock is equal to the net present value of the purchase price to be paid upon exercise of the Call Option and all dividends paid with respect to a share of Series
BRN Preferred from the original date of issuance and shall be calculated using the XIRR function in the most recent version of Microsoft Excel (or if such program is no longer available, such other software program for calculating IRR reasonably
proposed by the Company). 
 10.2 At any time after any holder of Series BRN Preferred Stock: 

(a) fails to purchase the minimum number of shares such holder is required to purchase at any Additional Closing (excluding, for the
avoidance of doubt, any purchase of Second Closing Remaining Shares, Third Closing Remaining Shares or Fourth Closing Remaining Shares (as each such term is defined in the Purchase Agreement)) after the satisfaction or waiver of the conditions set
forth in Section 4.2 of the Purchase Agreement (other than Section 4.2(e) of the Purchase Agreement) in accordance with the Purchase Agreement other than due to (i) a KPI Failure, (ii) an IPO or (iii) the closing of a Sale
of the Company; or 

  
 10 

 (b) breaches any of its material obligations under the Financing Agreements (as defined in
the Purchase Agreement) (including, for example, failing to assign ownership of any inventions made within the Project Company to the Company or failing to convert its shares of Series BRN Preferred Stock in accordance with the Company Charter),
which breach remains uncured for a period of thirty (30) days after such breach and provided, however, that the Company is not then itself in breach of its obligations under the applicable Financing Agreement(s); 

the Company shall have the right to exercise the Call Option at any time within two (2) months of such failure to purchase or breach (provided that
such two (2) month period shall commence on the date of delivery of written notice of such breach) with respect to all of the shares of Series BRN Preferred Stock held by such holder as of immediately prior to such failure to purchase or breach
or as of the date of the Exercise Notice (whichever is greater), at a per share purchase price of $6.00 (as adjusted for all stock splits, dividends, combinations, recapitalizations and the like affecting the Series BRN Preferred Stock) (the
“Minimum Exercise Price” and together with the IRR Exercise Price, the “Exercise Price”). 

10.3 If, at any time after the Initial Closing Date, a statute, rule, regulation, order, or interpretation shall have been enacted,
entered or deemed applicable by any domestic or foreign government or governmental or administrative agency or court which would make the transactions contemplated by the Purchase Agreement or the other Financing Agreements illegal and each of the
conditions to the obligations of RUSNANO and any Co-Investor set forth in Sections 4.2(a), (b), (c) and (d) of the Purchase Agreement, if applicable, have been satisfied, the Company shall have the right to exercise the Call Option in the
manner set forth in Section 10.4 below at a per share purchase price equal to the Minimum Exercise Price 
 10.4 The
Call Option shall be exercisable by the Company only by delivery of a written exercise notice stating the applicable Exercise Price (the “Exercise Notice”) to the holders of the Series BRN Preferred Stock. Upon delivery of an
Exercise Notice, the holders of the Series BRN Preferred Stock shall be obligated to sell all but not less than all of their shares of Series BRN Preferred Stock (and to promptly deliver any certificates representing the same, duly endorsed or
accompanied by an executed stock power) to the Company, and the Company shall be obligated to purchase such shares from the holders of the Series BRN Preferred Stock, in the manner and at the price contemplated in this Section 10. On a
date (the “Settlement Date”) that is within ten (10) business days after receipt of an Exercise Notice, the Company shall pay to the relevant holder the applicable Exercise Price determined in accordance with Sections
10.1, 10.2 or 10.3. Such payment may be effected in cash or by certified or official bank check or wire transfer to an account designated by the holders of the Series BRN Preferred Stock in writing. 

11. Series BRN Preferred Stock Voting Right. For so long as RUSNANO (or a controlled affiliate that is a permitted transferee
pursuant to Section 8.3) owns of record and beneficially all of the shares of Series BRN Preferred Stock purchased by RUSNANO under the Purchase Agreement, with respect to any action or failure to act which would require the consent,
affirmative vote, waiver, approval or execution of any instrument or agreement by the 

  
 11 

 
holders of a minimum specified portion of the outstanding shares of the Company’s Series BRN Preferred Stock (excluding, for the avoidance of doubt, any other shares of capital stock of the
Company), including, for the avoidance of doubt, the exercise of the redemption right set forth in Section 3.5 of the Company Charter, other than with respect to (a) the right to designate a director as set forth in
Section 1.6(b) (whether such requirement is set forth in the Company Charter, in this Agreement or in one or more of the other Financing Agreements), each holder of shares of Series BRN Preferred Stock agrees as follows: (i) with
respect to any such action or failure to act for which affirmative votes, consents, waivers, approvals or executed instruments or agreements, as the case may be, have been duly provided by RUSNANO, each such holder of the Series BRN Preferred Stock
hereby agrees to vote its shares of the Series BRN Preferred Stock in favor of, or execute such consents, waivers, approvals, instruments or agreements, as applicable, as shall be necessary to permit or effect, such action or failure to act, as the
case may be, in the same manner as RUSNANO and (ii) with respect to any such action or failure to act for which the affirmative vote, waiver or approval has not been obtained from RUSNANO, each such holder hereby agrees to refrain from voting
its shares of Series BRN Preferred Stock in favor of, and refrain from executing any consents, waivers, approvals, instruments or agreements, as applicable, that would permit or effect such action or failure to act, as the case may be. For the
avoidance of doubt, this Section 11 shall not apply to any person or entity, other than a holder of shares of Series BRN Preferred Stock. No amendment or modification of, or waiver under, this Section 11 shall be valid unless
in writing and signed by the Company and each Purchaser holding shares of Series BRN Preferred Stock. 
 12. General.

 12.1 Severability. The provisions of this Agreement are severable, so that the invalidity or unenforceability of any
provision of this Agreement shall not affect the validity or enforceability of any other term or provision of this Agreement, which shall remain in full force and effect. 
 12.2 Specific Performance. In addition to any and all other remedies that may be available at law in the event of any breach of this Agreement, each party hereto shall be entitled to specific
performance of the agreements and obligations of any other party hereto hereunder and to such other injunctive or other equitable relief as may be granted by a court of competent jurisdiction. 

12.3 Governing Law. This Agreement shall be governed by, and construed and enforced in accordance with, the General Corporation
Law of the State of Delaware as to matters within the scope thereof, and as to all other matters shall be governed by, and construed and enforced in accordance with, the internal laws of the State of New York, without regard to conflict of law
principles that would result in the application of any law other than the law of the State of New York. 

  
 12 

 12.4 Notices. All notices, requests, consents, and other communications under this
Agreement shall be in writing and shall be deemed delivered (a) for notices sent by the Company to addressees within the United States, two (2) business days after being sent by registered or certified mail, return receipt requested,
postage prepaid, (b) three (3) business days after being sent via a reputable international courier service with expedited delivery, in each case to the intended recipient as set forth below, or (c) immediately upon being sent by
facsimile, provided that the sender receives electronic confirmation of delivery, or electronic mail: 
 If to the Company:

 BIND Biosciences, Inc. 
 64 Sidney Street 
 Cambridge, Massachusetts 02139 

Attn: President 

Fax: 617-491-0351 
 E-mail: scottminick@bindbio.com 
 with a copy to: 

Peter N. Handrinos, Esquire 
 Latham & Watkins LLP 
 John Hancock Tower 

200 Clarendon Street, 20th Floor 
 Boston, Massachusetts 02116 
 Fax: 617-948-6001 

E-mail: peter.handrinos@lw.com 
 (i) If to a Purchaser, at its address set forth in Schedule A hereto, or at such other address as may have been furnished to the other parties hereto in writing by such Purchaser; 

(ii) If to an Other Stockholder, at its address set forth in Schedule C hereto, or at such other address as may have been
furnished to the other parties hereto in writing by such Other Stockholder; and 
 (iii) If to a Founder or Executive Officer,
at the Company or at such other address or addresses as may have been furnished to the other parties hereto in writing by such Founder. 
 Any party may give any notice, request, consent or other communication under this Agreement using any other means (including, without limitation, personal delivery, messenger service, first class mail or
electronic mail), but no such notice, request, consent or other communication shall be deemed to have been duly given unless and until it is actually received by the party for whom it is intended. Any party may change the address to which notices,
requests, consents or other communications hereunder are to be delivered by giving the other parties notice in the manner set forth in this Section 12.4. 
 12.5 Complete Agreement; Amendments. This Agreement constitutes the entire agreement and understanding of the parties hereto with respect to the subject matter hereof, and supersedes all prior
agreements and understandings relating to such subject matter, including the Former Voting Agreement. No amendment, modification or termination of, or waiver under any provision of this Agreement shall be valid unless in writing and signed by (i)

  
 13 

 
the Company, (ii) the Founders holding shares representing a majority of the voting power of the Shares then held by all of the Founders, provided that, for purposes of this provision, the
Shares held by the trusts listed on Schedule C hereto shall be included in the calculation of Shares held by their respective settlors and (iii) Purchasers holding shares (other than Series BRN Preferred Stock) representing at least
sixty-five percent (65%) of the voting power of the Shares (other than shares of Series BRN Preferred Stock) then held by all of the Purchasers, and any such amendment, modification, termination or waiver shall be binding on all parties hereto;
provided that any such waiver or amendment which materially and adversely affects the rights, privileges, duties or obligations of a Purchaser in a manner materially different than those of all other Purchasers shall not be effective against such
affected Purchaser without the written consent of such affected Purchaser. Notwithstanding anything to the contrary herein, this Agreement may be amended by the Company without the consent of any of the other parties hereto to add as a party hereto
and include information regarding and otherwise accommodate an additional purchaser of shares of Series D Preferred Stock or Series BRN Preferred Stock (including a Co-Investor) pursuant to the Purchase Agreement, as may be amended from time to
time; provided that any such amendment does not materially and adversely affect the rights of any Purchaser under this Agreement (it being agreed that the issuance of additional shares of capital stock in accordance with the Purchase Agreement, as
may be amended or modified from time to time in accordance with its terms, and the other Financing Documents, each as may be amended or modified from time to time in accordance with its respective terms, shall not be deemed to affect the Purchasers
under this Agreement). Notwithstanding the foregoing, no amendment, modification or waiver under this Agreement shall be made: 

(a) affecting the obligation of the Stockholders to elect the Polaris Director without the written consent of Polaris so long as Polaris
holds at least ten percent (10%) of all outstanding shares of the Company’s preferred stock (including Series A Preferred Stock, Series B Preferred Stock, Series C Preferred Stock, Series C-1 Preferred Stock, Series D Preferred Stock and
any subsequently issued class or series of preferred stock), other than the Series BRN Preferred Stock or any shares issued in the circumstances specified in Article Fourth, Section 3.3(f)(i)(4)(A)-(I) of the Company Charter, on an
as­converted-to-Common Stock basis (the “10% Threshold”); 
 (b) affecting the obligation of the
Stockholders to elect the Flagship Director without the written consent of Flagship so long as Flagship holds at least the 10% Threshold; 
 (c) affecting the obligation of the Stockholders to elect the ARCH Director without the written consent of ARCH so long as ARCH holds at least the 10% Threshold; 

(d) affecting the obligation of the Stockholders to elect Koch to the Board of Directors without the written consent of DHK so long as
DHK holds at least six percent (6%) of the sum of: the total number of shares of Common Stock then outstanding plus the number of shares of Common Stock issuable upon conversion or exchange of then outstanding Preferred Stock or other
convertible securities or exercise of then outstanding options, rights or warrants (but not including any shares issued in the circumstances specified in Article Fourth, Section 3.3(f)(i)(4)(A)-(I) of the Company Charter) on an
as-converted-to-Common Stock basis (the “Fully Diluted Shares”); 

  
 14 

 (e) affecting NanoDimension’s rights set forth in Section 1.2(a) with
respect to the NanoDimension Observer without the written consent of NanoDimension; 
 (f) affecting DHK’s rights set
forth in Section 1.2(b) without the written consent of DHK; 
 (g) affecting the rights of Doelger and Bertsimas
set forth in Section 1.2(c) without the written consent of Doelger, for so long as such Stockholders collectively hold at least four and two-tenths percent (4.2%) of the Fully Diluted Shares of the Company; 

(h) affecting the rights of Endeavour, Gerald W. Blakeley, Jr., Gerald W. Blakeley, III or D2 Investment set forth
in Section 1.2(d) without the written consent of Endeavour, Blakeley and D2 Investment, for so long as such Stockholders collectively hold at least four and two-tenths percent (4.2%) of the Fully Diluted Shares of the Company;

 (i) affecting the obligation of the Stockholders to elect the RUSNANO Director without the written consent of RUSNANO so
long as RUSNANO (or a controlled affiliate that is a permitted transferee pursuant to Section 8.3) holds at least ten percent (10%) of all outstanding shares of the Company’s preferred stock (including Series A Preferred Stock,
Series B Preferred Stock, Series C Preferred Stock, Series C-1 Preferred Stock, Series D Preferred Stock, Series BRN Preferred Stock and any subsequently issued class or series of preferred stock), or any shares issued in the circumstances specified
in Article Fourth, Section 3.3(f)(i)(4)(A)-(I) of the Company Charter, on an as-converted-to-Common Stock basis; 
 (j) to Section 11 except as specifically provided therein; or 
 (k)
without the written consent of all of the holders who would be required to exercise the drag-along right in accordance with Section 3.2, if such amendment, modification or waiver would change the voting thresholds set forth in
Section 3.2. 
 12.6 Construction. A reference to a Section or Schedule shall mean a Section in or Schedule
to this Agreement unless otherwise expressly stated. The titles and headings herein are for reference purposes only and shall not in any manner limit the construction of this Agreement which shall be considered as a whole. The words
“include,” “includes” and “including” when used herein shall be deemed in each case to be followed by the words “without limitation.” Whenever the context may require, any pronouns used herein shall include
the corresponding masculine, feminine or neuter forms, and the singular form of names and pronouns shall include the plural and vice-versa. 
 12.7 Counterparts; Facsimile Signatures. This Agreement may be executed in any number of counterparts, each of which shall be deemed to be an original, and all of which together shall constitute
one and the same document. This Agreement may be executed by facsimile signatures. 

  
 15 

 12.8 Additional Purchasers. Notwithstanding Section 12.5, any person or
entity that purchases Series BRN Preferred Stock as a Co-Investor (as defined in the Purchase Agreement) under the Purchase Agreement shall become a party to this Agreement by executing and delivering to the Company a counterpart signature page to
this Agreement, and thereupon shall be deemed a “Purchaser” for all purposes of this Agreement, and the Company shall amend Schedule A hereto to add the name and address of such Purchaser. No such accession instrument shall be
effective unless and until accepted in writing by the Company. Except as required by the preceding sentence, no action or consent by the Purchasers, Founders, Executive Officers or Other Stockholders shall be required for such joinder to this
Agreement by such Co-Investor or any aforesaid amendment of Schedule A, so long as such Co-Investor has agreed in writing to be bound by all of the obligations as an “Purchaser” hereunder. 

12.9 Additional Common Holders. In the event that after the date of this Agreement, the Company issues shares of capital stock to
any employee or consultant, which shares constitute two percent (2%) or more of the Company’s then outstanding capital stock (treating for this purpose all shares of Common Stock issuable upon exercise of or conversion of outstanding
options, warrants or convertible securities, as if exercised or converted), the Company shall use its best efforts to cause such person to execute a counterpart signature page hereto as a “Stockholder”, and such person shall thereby be
bound by, and subject to, all the terms and provisions of this Agreement applicable to a Stockholder. In addition, with the consent of the Company, any other Stockholder may become a party to this Agreement as an “Other Stockholder” by
executing and delivering a counterpart signature page hereto to the Company, and such person shall thereby be bound by, and subject to, all the terms and provisions of this Agreement applicable to an Other Stockholder; provided that no such joinder
shall be effective unless and until accepted in writing by the Company. No action or consent by the other parties to this Agreement shall be required for such joinder to this Agreement by such additional Other Stockholder, and upon any such joinder,
the Company shall update Schedule C hereto to reflect the addition of such Other Stockholder as a party hereto. 
 12.10
Additional Shares. Each Stockholder agrees to vote all of the shares it holds, in whatever manner shall be necessary to authorize an increase in the authorized capital stock of the Company so that there will be sufficient shares of Common
Stock available for conversion of all of the then-outstanding shares of Preferred Stock and Series BRN Preferred Stock at any time that an adjustment to the applicable Conversion Price (as defined in the Company Charter) is made pursuant to
Article Fourth, Section 3.3(f)(iv) of the Company Charter. 
 12.11 Amended and Restated Agreement. All
provisions of, rights granted and covenants made in the Former Voting Agreement are hereby superseded in their entirety and shall have no further force or effect. Each of the Founders and the Prior Purchasers acknowledge and agree that the execution
and delivery by the Company of this Agreement, the Purchase Agreement and the additional Financing Agreements and the performance by the Company of its obligations thereunder do not constitute a default under the provisions of the Former Voting
Agreement. 
 12.12 Dispute Resolution. Any dispute, controversy or claim arising out of or relating to this Agreement,
including its existence, validity, interpretation, performance, non-performance, 

  
 16 

 
breach or termination (collectively, the “Dispute”) shall be finally settled under the Rules of Arbitration of the International Chamber of Commerce (the “ICC
Rules”), except as they may be modified herein or by mutual agreement of the parties. The Dispute shall be resolved by three (3) arbitrators appointed in the following manner: each party shall nominate an arbitrator for
confirmation as provided in the ICC Rules and following their confirmation, the third arbitrator shall be appointed by the International Court of Arbitration of the International Chamber of Commerce; provided, however, that at least one (1) of
such arbitrators shall have substantive expertise in the pharmaceutical industry. The place of arbitration shall be New York, New York. The language of the arbitration shall be English. The tribunal shall determine the proportion of
the costs of the arbitration which each party shall bear. The award shall be final, conclusive and binding upon the parties hereto. Judgment upon the award may be entered by any court having jurisdiction thereof or having jurisdiction over
the relevant party or its assets. 
 [Remainder of page intentionally left blank.] 

  
 17 

 IN WITNESS WHEREOF, the parties hereto have executed this Fourth Amended and Restated Voting
Agreement as an instrument under seal as of the date first above written. 
  

							
	COMPANY:	 		 	BIND BIOSCIENCES, INC.
				
		 		 	By:	 	 /s/ Scott Minick

		 		 		 	Scott Minick
		 		 		 	President and Chief Executive Officer
			
	FOUNDERS:	 		 	 /s/ Omid Farokhzad

		 		 	Omid Farokhzad
			
		 		 	  

		 		 	Paul Goldenheim
			
		 		 	 /s/ Robert S. Langer, Jr.

		 		 	Robert S. Langer, Jr.
			
	EXECUTIVE OFFICERS:	 		 	 /s/ Scott Minick

		 		 	Scott Minick

 Signature Page to Fourth Amended and Restated Voting Agreement 

							
	PURCHASERS:	 	POLARIS VENTURE PARTNERS V, L.P.
		 	By:	 	POLARIS VENTURE MANAGEMENT CO. V, L.L.C., its General Partner
				
		 		 	By:	 	 /s/ William E. Bilodeau

		 		 		 	William E. Bilodeau
		 		 		 	Attorney-in-fact
		
		 	POLARIS VENTURE PARTNERS ENTREPRENEURS’ FUND V, L.P.
			
		 	By:	 	POLARIS VENTURE MANAGEMENT CO. V, L.L.C., its General Partner
				
		 		 	By:	 	 /s/ William E. Bilodeau

		 		 		 	William E. Bilodeau
		 		 		 	Attorney-in-fact
		
		 	POLARIS VENTURE PARTNERS FOUNDERS’ FUND V, L.P.
			
		 	By:	 	POLARIS VENTURE MANAGEMENT CO. V, L.L.C., its General Partner
				
		 		 	By:	 	 /s/ William E. Bilodeau

		 		 		 	William E. Bilodeau
		 		 		 	Attorney-in-fact
		
		 	POLARIS VENTURE PARTNERS SPECIAL FOUNDERS’ FUND V, L.P.
			
		 	By:	 	POLARIS VENTURE MANAGEMENT CO. V, L.L.C., its General Partner
				
		 		 	By:	 	 /s/ William E. Bilodeau

		 		 		 	William E. Bilodeau
		 		 		 	Attorney-in-fact

 Signature Page to Fourth Amended and Restated Voting Agreement 

							
	PURCHASER:	 	FLAGSHIP VENTURES FUND 2004, L.P.
			
		 	By:	 	FLAGSHIP VENTURES GENERAL PARTNER LLC, its General Partner
				
		 		 	By:	 	 /s/ Noubar Afeyan

		 		 		 	Noubar Afeyan
		 		 		 	Managing Partner and CEO

 Signature Page to Fourth Amended and Restated Voting Agreement 

							
	PURCHASER:	 		 	ARCH VENTURE FUND VII, L.P.
				
		 		 	By:	 	ARCH VENTURE PARTNERS VII, L.P.
		 		 	Its:	 	General Partner
				
		 		 	By:	 	ARCH VENTURE PARTNERS VII, LLC
		 		 	Its:	 	General Partner
				
		 		 	By:	 	 /s/ Clinton W. Bybee

		 		 	Its:	 	Managing Director

 Signature Page to Fourth Amended and Restated Voting Agreement 

							
	PURCHASER:	 		 	NANODIMENSION, L.P.
				
		 		 	By:	 	NanoDimension Management Limited, its General Partner
				
		 		 	By:	 	 /s/ Jonathan Nicholson

		 		 		 	Jonathan Nicholson, Director

 Signature Page to Fourth Amended and Restated Voting Agreement 

							
	PURCHASER:	 		 	DHK INVESTMENTS, LLC
				
		 		 	By:	 	 /s/ David H. Koch

		 		 		 	David H. Koch
		 		 		 	Manager

 Signature Page to Fourth Amended and Restated Voting Agreement 

							
	PURCHASER:	 		 		 	
				
		 		 		 	 /s/ Peter W. Doelger

		 		 		 	Peter W. Doelger

 Signature Page to Fourth Amended and Restated Voting Agreement 

							
	PURCHASER:	 		 		 	DOELGER FAMILY 2006 TRUST
		 		 		 	FBO EMILY M. DOELGER
				
		 		 		 	 /s/ Bruce A. Haverberg

		 		 		 	Bruce A. Haverberg, Trustee
				
		 		 		 	DOELGER FAMILY 2006 TRUST
		 		 		 	FBO MATTHEW DOELGER
				
		 		 		 	 /s/ Bruce A. Haverberg

		 		 		 	Bruce A. Haverberg, Trustee
				
		 		 		 	HEE-JEAN KIM 2007 TRUST
				
		 		 		 	 /s/ Bruce A. Haverberg

		 		 		 	Bruce A. Haverberg, Trustee

 Signature Page to Fourth Amended and Restated Voting Agreement 

							
	PURCHASER:	 		 		 	
				
		 		 		 	 /s/ Dimitris Bertsimas

		 		 		 	Dimitris Bertsimas

 Signature Page to Fourth Amended and Restated Voting Agreement 

							
	PURCHASER:	 		 	ENDEAVOUR II L.P.
				
		 		 	By:	 	ENDEAVOUR PARTNERS GP LIMITED
		 		 		 	its General Partner
				
		 		 	By:	 	 /s/ John Bridle

		 		 		 	Name: John Bridle
		 		 		 	Title:   Director

 Signature Page to Fourth Amended and Restated Voting Agreement 

							
	PURCHASER:	 		 		 	
				
		 		 		 	 /s/ Gerald W. Blakeley, Jr.

		 		 		 	Gerald W. Blakeley, Jr.

 Signature Page to Fourth Amended and Restated Voting Agreement 

							
	PURCHASER:	 		 		 	
				
		 		 		 	 /s/ Gerald W. Blakeley, III

		 		 		 	Gerald W. Blakeley, III

 Signature Page to Fourth Amended and Restated Voting Agreement 

							
	PURCHASER:	 		 	D2 INVESTMENT LLC
				
		 		 	By:	 	 /s/ Chris Kryder

		 		 		 	Chris Kryder
		 		 		 	Manager

 Signature Page to Fourth Amended and Restated Voting Agreement 

							
	PURCHASER:	 		 		 	
				
		 		 		 	 /s/ Peter T. Scardino

		 		 		 	Peter T. Scardino

 Signature Page to Fourth Amended and Restated Voting Agreement 

							
	PURCHASER:	 		 		 	
				
		 		 		 	 /s/ Edwin Darracott Vaughan, Jr.

		 		 		 	Edwin Darracott Vaughan, Jr.

 Signature Page to Fourth Amended and Restated Voting Agreement 

							
	PURCHASER:	 		 		 	JOHN T. CONNOR JR. AND SUSAN SCHOLLE CONNOR, tenants by the entirety
				
		 		 		 	 /s/ John T. Connor Jr.

		 		 		 	John T. Connor Jr.
				
		 		 		 	 /s/ Susan Scholle Connor

		 		 		 	Susan Scholle Connor

 Signature Page to Fourth Amended and Restated Voting Agreement 

							
	PURCHASER:	 		 		 	
				
		 		 		 	 /s/ Jeffrey B. Larson

		 		 		 	Jeffrey B. Larson

 Signature Page to Fourth Amended and Restated Voting Agreement 

							
	PURCHASER:	 		 		 	
				
		 		 		 	 /s/ Megan Kelleher

		 		 		 	Megan Kelleher

 Signature Page to Fourth Amended and Restated Voting Agreement 

							
	PURCHASER:	 		 	RUSNANO
		 		 	an open joint stock company organized and existing under the laws of the Russian Federation
				
		 		 	By:	 	 /s/ Andrey Malyshev

		 		 	Name:	 	Andrey Malyshev
		 		 	Title:	 	Deputy Chairman of the Management Board

 Signature Page to Fourth Amended and Restated Voting Agreement 

 SCHEDULE A 
 Names and Addresses of Purchasers 

 

	
	Polaris Venture Partners V, L.P.
	1000 Winter Street, Suite 3350
	Waltham, MA 02451
	Attn: Amir H. Nashat
	Fax: 781.290.0880
	  
 Polaris Venture
Partners
Entrepreneurs’ Fund V, L.P.

	1000 Winter Street, Suite 3350
	Waltham, MA 02451
	Attn: Amir H. Nashat
	Fax: 781.290.0880
	  
 Polaris Venture
Partners
Founders’ Fund V, L.P.

	1000 Winter Street, Suite 3350
	Waltham, MA 02451
	Attn: Amir H. Nashat
	Fax: 781.290.0880
	  
 Polaris Venture
Partners
Special Founders’ Fund V, L.P.

	1000 Winter Street, Suite 3350
	Waltham, MA 02451
	Attn: Amir H. Nashat
	Fax: 781.290.0880
	  
 Flagship Ventures Fund 2004, L.P.

	One Memorial Drive, 7th Floor
	Cambridge, MA 02142
	Fax: 617.868.1115
	  
 ARCH Venture Fund VII, L.P.

	c/o ARCH Venture Partners
	8725 W. Higgins Road, Suite 290
	Chicago, IL 60631
	mmcdonnell@archventure.com
	Fax: ++1 773-380-6606
	  
 Alexandria Equities, LLC

	385 E. Colorado Boulevard, Suite 299
	Pasadena, CA 91101
	 Attn: Joel S. Marcus, CEO

investments@labspace.com

 

	
	NanoDimension L.P.
	Attention Jonathan Nicholson
	Governor’s Square, Unit 3-213-6
	P.O. Box 526 WB
	23, Lime Tree Bay Ave
	Grand Cayman, KY1-1302
	Cayman Islands
	Fax: 345 946 5558
	  
 DHK Investments, LLC

	c/o Koch Family Management
	4111 East 37th Street North
	Wichita, KS 67220
	Fax: 816.828.8602
	  
 Copies to (which does not constitute
notice):

	  
 Koch Companies Public Sector,
LLC

	 4111 East 37th
Street North

	 Wichita, KS 67220

	 Attention: Raffaele G. Fazio

	 Fax: 816.828.8602

	  
 and

	  
 Jones Day

	 3161 Michelson Drive, Suite 800

	 Irvine, CA 92612

	 Attention: Craig S. Mordock

	 Fax: 949.553.7539

	  
 Peter W. Doelger

	144 Beacon Street, Apt. 3
	Boston, MA 02116-1449
	  
 Doelger Family 2006 Trust

	FBO Emily M. Doelger
	c/o Bruce A. Haverberg, Trustee
	10 Tremont Street, Suite 200
	Boston, MA 02108

 
 

	
	Doelger Family 2006 Trust
	FBO Matthew Doelger
	c/o Bruce A. Haverberg, Trustee
	10 Tremont Street, Suite 200
	Boston, MA 02108
	  
 Hee-Jean Kim 2007 Trust

	c/o Bruce A. Haverberg, Trustee
	10 Tremont Street, Suite 200
	Boston, MA 02108
	  
 Dimitris Bertsimas

	43 Lantern Rd
	Belmont, MA 02478-1706
	  
 In each case, with a copy to (which does not constitute
notice):

	  
 Paul G. Roberts

	 300 First Avenue

	 Needham, MA. 02494

	 Fax: (781) 707-2551

	  
 Endeavour II L.P.

	PO Box 255 Trafalgar Court
	Les Banques
	St Peter Port, Guernsey GY1 3QL
	Channel Islands
	  
 Copy (which does not constitute notice)
to:

	  
 Endeavour Vision SA

	 6 rue de la Croix d’Or

	 1204 Geneva, Switzerland

	  
 Jeffrey B. Larson

	6 Arlington Street, Unit 5
	Boston, MA 02116
	Fax: 617-849-5910
	jeff@vaksam.com
	  
 Megan Kelleher

	444 Far Reach Road
	Westwood, MA 02090
	Fax: 617-849-5910
	k.megan.kelleher@gmail.com

 

	
	Gerald W. Blakeley, Jr.
	Blakeley Investment Company
	60 State Street – Suite 3400
	Boston, MA 02109
	  
 Gerald W. Blakeley, III

	Oyster Harbors 2057
	250 Windswept Way
	Osterville, MA 02655
	  
 In each case, with a copy to (which does not constitute
notice):

	  
 William S. Abbott, Esq.

	 50 Congress Street, Suite 925

	 Boston, MA 02109

	  
 D2 Investment LLC

	72 Pine Ridge Rd
	Newton, MA 02468
	  
 Peter T. Scardino

	345 E 68th Street
	New York, NY 10065
	Fax: (646) 422-1095
	  
 Edwin Darracott Vaughan, Jr.

	89 Hollow Creek Road
	Sheridan, WY 82801
	Tel: (307) 671-0429
	  
 John T. Connor Jr. and Susan Scholle

	Connor
	PO Box 1916
	Cotuit, MA 02635
	Tel: (508) 428-2050
	  
 RUSNANO

	10A prospect 60-letiya Oktyabrya
	Moscow, Russia 117036
	Attn: Dmitriy Lisenkov
	Fax: +74959885388
	Dmitriy.Lisenkov@rusnano.com
	Attn: Leysan Shaydullina
	Fax: +7495988538
	Leysan.shaydullina@rusnano.com

 
 

 SCHEDULE B 
 Executive Officers 
 Scott Minick 

 SCHEDULE C 
 Other Stockholders 
  

			
	Pamela Basto	  	Rohit Karnik
	125 Liberty Rd #3	  	931 Massachusetts Ave., Apt. 7
	Somerville, MA 02144	  	Cambridge, MA 02139
		
	Chris Canizzaro	  	Alireza Khademhosseini
	413 North Avenue	  	16 Trowbridge Street, #32
	Weston, MA 02493	  	Cambridge, MA 02138
		
	Jianjun Cheng	  	Maria Teresa Peracchia
	2304 Lynwood Drive	  	18 Rue Cuvier
	Champaign, IL 61821	  	75005 Paris, France
		
	Abraham J. Domb	  	Aleksandar Filip Radovic-Moreno
	16 Migdal Eder Street	  	1055 Crabapple Drive
	EFRAT, 90435 Israel	  	State College, PA 16801
		
	Ruxandra Gref	  	Benjamin A. Teply
	14 rue Moulin Fidel, apt G62	  	5109 Nicholas St.,
	92350 Plessis Robinson, France	  	Omaha, NE 68132-1433
		
	Sangyong Jon	  	Liangfang Zhang
	Dept. of Life Science, GIST	  	6191 Blue Dawn Trail
	1-Oryong dong, Bukgu	  	San Diego, CA 92130
	Gwangju 500-71, Republic of Korea	  	
		  	Susan K. Langer Trust u/d/t 12/14/95
	The OCF Irrevocable Trust 2006	  	c/o Stephanie K. Meilman, Trustee
	c/o Shadi K. Aryanpour, Trustee	  	Law Office of Meilman & Costa, P.C.
	490 Beacon Street	  	70 Wells Avenue, Suite 200
	Chestnut Hill, MA 02476	  	Newton, MA 02459
		
	The SAF Irrevocable Trust 2006	  	Samuel A. Langer Trust u/d/t 12/14/95
	c/o Shadi K. Aryanpour, Trustee	  	c/o Stephanie K. Meilman, Trustee
	490 Beacon Street	  	Law Office of Meilman & Costa, P.C.
	Chestnut Hill, MA 02476	  	70 Wells Avenue, Suite 200
		  	Newton, MA 02459
	 Michael D. Langer Trust u/d/t 12/14/95
 c/o Stephanie K. Meilman, Trustee
	  	
	Law Office of Meilman & Costa, P.C.	  	
	70 Wells Avenue, Suite 200	  	
	Newton, MA 02459	  	

 AMENDMENT NO. 1 

TO 

FOURTH AMENDED AND RESTATED VOTING AGREEMENT 
 THIS AMENDMENT NO. 1 TO FOURTH AMENDED AND RESTATED VOTING AGREEMENT (this “Amendment”) is made and entered into as of November 27, 2012, by and between BIND Biosciences,
Inc., a Delaware corporation (the “Company”), and the undersigned stockholders of the Company.  

WHEREAS, the Company and certain stockholders of the Company entered into that certain Fourth Amended and Restated Voting
Agreement, dated as of November 7, 2011 (the “Agreement”); 
 WHEREAS, pursuant to
Section 12.5 of the Agreement, the Agreement may be amended by written agreement of (i) the Company, (ii) the Founders holding shares representing a majority of the voting power of the Shares then held by all of the Founders, provided
that, for purposes of this provision, the Shares held by the trusts listed on Schedule C of the Agreement shall be included in the calculation of Shares held by their respective settlors and (iii) Purchasers holding shares (other than
Series BRN Preferred Stock) representing at least sixty-five percent (65%) of the voting power of the Shares (other than shares of Series BRN Preferred Stock) then held by all of the Purchasers (collectively, the “Requisite
Parties”); 
 WHEREAS, the Company and the undersigned stockholders of the Company constitute the Requisite
Parties; and 
 WHEREAS, the parties hereto desire to amend the Agreement as set forth herein. 

NOW, THEREFORE, for good and valuable consideration, the receipt and adequacy of which are hereby acknowledged, the parties hereto
hereby covenant and agree to be bound as follows: 
 Section 1. Capitalized Terms. Capitalized terms used herein and
not otherwise defined herein shall have the respective meanings assigned to them in the Agreement. 
 Section 2.
Amendments. 
 (a) Section 1.1(a) of the Agreement is hereby amended and restated in its entirety to read as follows:

 “(a) fix the number of directors of the Company at eleven (11);” 

(b) Section 1.1(b) of the Agreement is hereby amended and restated in its entirety to read as follows: 

“(b) elect the following persons as directors: (i) one person designated by Polaris Venture Partners IV, L.P. or an Affiliated
Entity (as defined in Section 8.2) thereof (“Polaris”), who shall initially be Amir Nashat (the “Polaris Director”); (ii) one person designated by Flagship Ventures Fund 2004, L.P. or an Affiliated
Entity thereof (“Flagship”), who shall initially be Noubar Afeyan (the “Flagship Director”); (iii) one person designated by ARCH Venture Fund VII, L.P. (“ARCH”) or an Affiliated Entity thereof
(the “ARCH Director”), which seat shall initially be vacant; (iv) one person designated by DHK Investments, LLC (“DHK”), who may only be David H. Koch (“Koch”); (v) two directors each
designated by a majority of the Founders, who shall 

 
initially be Omid Farokhzad and Robert S. Langer, Jr.; (vi) the person who shall serve from time to time as the chief executive officer of the Company, initially Scott Minick;
(vii) one person designated by RUSNANO, an open joint stock company organized and existing under the laws of the Russian Federation (“RUSNANO”), who must be either a member of RUSNANO’s executive board or an experienced
global pharmaceutical executive with predefined qualification requirements consistent with those applied in relation to the other members of the Board of Directors and who shall initially be Yuriy Udaltsov (the “RUSNANO Director”);
(viii) two persons not otherwise Affiliates of the Company and designated by a majority of the other directors (the “Outside Directors”), one of whom shall initially be Peter Barton Hutt, and the other of which seats shall
initially be vacant; and (ix) one additional person designated by a majority of the other directors, who shall initially be Daniel S. Lynch; and” 
 Section 3. No Other Amendments; Conflicts. No term or provision of the Agreement shall be affected by this Amendment, unless specifically set forth herein and any term or provision not
affected by this Amendment shall remain in full force and effect following the date hereof. In the event of a conflict between the terms of the Agreement and the terms of this Amendment, the terms of this Amendment shall control. 

Section 4. Governing Law. This Amendment shall be governed by, and construed and enforced in accordance with, the General
Corporation Law of the State of Delaware as to matters within the scope thereof, and as to all other matters shall be governed by, and construed and enforced in accordance with, the internal laws of the State of New York, without regard to conflict
of law principles that would result in the application of any law other than the law of the State of New York. 

Section 5. Captions; Pronouns. All articles and section headings or captions contained in this Amendment are inserted only as
a matter of convenience and for reference and in no way define, limit, extend or describe the scope of this Amendment or the intent of any provision thereof. 
 Section 6. Severability. If any provision of this Amendment or application to any party or circumstance shall be determined by any court of competent jurisdiction to be invalid or
unenforceable to any extent, the remainder of this Amendment or the application of such provision to any other party or circumstances shall not be affected thereby, and each provision shall be valid and shall be enforced to the fullest extent
permitted by law. 
 Section 7. Counterparts. This Amendment may be executed in multiple counterparts, each of which
shall be deemed an original, but all of which taken together shall constitute one and the same instrument. The exchange of copies of this Amendment and of signature pages by facsimile transmission or other electronic means shall constitute effective
execution and delivery of this Amendment as to the parties and may be used in lieu of the original Amendment for all purposes. 

[Signature Page Follows] 

 IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be executed as
of the date first written above. 
  

			
	BIND BIOSCIENCES, INC.
		
	By:	 	 /s/ Scott Minick

	Name:	 	Scott Minick
	Title:	 	President and Chief Executive Officer

  

Signature Page to Amendment No. 1 to Fourth Amended and Restated Voting Agreement 

							
	FOUNDERS:	 		 		 	 /s/ Omid Farokhzad

		 		 		 	Omid Farokhzad
				
		 		 		 	  

		 		 		 	Paul Goldenheim
				
		 		 		 	 /s/ Robert S. Langer, Jr.

		 		 		 	Robert S. Langer, Jr.
				
	EXECUTIVE OFFICERS:	 		 		 	 /s/ Scott Minick

		 		 		 	Scott Minick

  

Signature Page to Amendment No. 1 to Fourth Amended and Restated Voting Agreement 

											
	PURCHASERS:	 		 	POLARIS VENTURE PARTNERS V, L.P.
		 		 	By:	 	POLARIS VENTURE MANAGEMENT CO. V, L.L.C., its General Partner
						
		 		 		 		 	By:	 	 /s/ William E. Bilodeau

		 		 		 		 	William E. Bilodeau
		 		 		 		 	Attorney-in-fact
			
		 		 	POLARIS VENTURE PARTNERS ENTREPRENEURS’ FUND V, L.P.
				
		 		 	By:	 	POLARIS VENTURE MANAGEMENT CO. V, L.L.C., its General Partner
						
		 		 		 		 	By:	 	 /s/ William E. Bilodeau

		 		 		 		 	William E. Bilodeau
		 		 		 		 	Attorney-in-fact
			
		 		 	POLARIS VENTURE PARTNERS FOUNDERS’ FUND V, L.P.
				
		 		 	By:	 	POLARIS VENTURE MANAGEMENT CO. V, L.L.C., its General Partner
						
		 		 		 		 	By:	 	 /s/ William E. Bilodeau

		 		 		 		 	William E. Bilodeau
		 		 		 		 	Attorney-in-fact
			
		 		 	POLARIS VENTURE PARTNERS SPECIAL FOUNDERS’ FUND V, L.P.
				
		 		 	By:	 	POLARIS VENTURE MANAGEMENT CO. V, L.L.C., its General Partner
						
		 		 		 		 	By:	 	 /s/ William E. Bilodeau

		 		 		 		 	William E. Bilodeau
		 		 		 		 	Attorney-in-fact

  
 Signature
Page to Amendment No. 1 to Fourth Amended and Restated Voting Agreement 

											
	PURCHASER:	 		 	FLAGSHIP VENTURES FUND 2004, L.P.
				
		 		 	By:	 	FLAGSHIP VENTURES GENERAL PARTNER LLC, its General Partner
						
		 		 		 		 	By:	 	 /s/ Noubar Afeyan

		 		 		 		 	Noubar Afeyan
		 		 		 		 	Managing Partner and CEO

  
 Signature
Page to Amendment No. 1 to Fourth Amended and Restated Voting Agreement 

							
	PURCHASER:	 		 	ARCH VENTURE FUND VII, L.P.
				
		 		 	By:	 	ARCH VENTURE PARTNERS VII, L.P.
		 		 	Its:	 	General Partner
				
		 		 	By:	 	ARCH VENTURE PARTNERS VII, LLC
		 		 	Its:	 	General Partner
				
		 		 	By:	 	 /s/ Clinton W. Bybee

		 		 	Its:	 	Managing Director

  
 Signature
Page to Amendment No. 1 to Fourth Amended and Restated Voting Agreement 

							
	PURCHASER:	 		 	NANODIMENSION, L.P.
				
		 		 	By:	 	NanoDimension Management Limited, its General Partner
				
		 		 	By:	 	 /s/ Jonathan Nicholson

		 		 		 	Jonathan Nicholson, Director

  
 Signature
Page to Amendment No. 1 to Fourth Amended and Restated Voting Agreement 

							
	PURCHASER:	 		 	DHK INVESTMENTS, LLC
				
		 		 	By:	 	 /s/ David H. Koch

		 		 		 	David H. Koch
		 		 		 	Manager

  
 Signature
Page to Amendment No. 1 to Fourth Amended and Restated Voting Agreement 

 PURCHASER: 

 

	
	 /s/ Peter W. Doelger

	Peter W. Doelger

  
 Signature
Page to Amendment No. 1 to Fourth Amended and Restated Voting Agreement 

							
	PURCHASER:	 		 		 	DOELGER FAMILY 2006 TRUST
		 		 		 	FBO EMILY M. DOELGER
				
		 		 		 	 /s/ Bruce A. Haverberg

		 		 		 	Bruce A. Haverberg, Trustee
				
		 		 		 	DOELGER FAMILY 2006 TRUST
		 		 		 	FBO MATTHEW DOELGER
				
		 		 		 	 /s/ Bruce A. Haverberg

		 		 		 	Bruce A. Haverberg, Trustee
				
		 		 		 	HEE-JEAN KIM 2007 TRUST
				
		 		 		 	 /s/ Bruce A. Haverberg

		 		 		 	Bruce A. Haverberg, Trustee

  
 Signature
Page to Amendment No. 1 to Fourth Amended and Restated Voting Agreement 

 PURCHASER: 

 

	
	 /s/ Dimitris Bertsimas

	Dimitris Bertsimas

  
 Signature
Page to Amendment No. 1 to Fourth Amended and Restated Voting Agreement 

									
	PURCHASER:	 		 	ENDEAVOUR II L.P.
				
		 		 	By:	 	ENDEAVOUR PARTNERS GP LIMITED its General Partner
				
		 		 	By:	 	 /s/ John Bridle

		 		 		 	Name:	 	John Bridle
		 		 		 	Title:	 	Director

  
 Signature
Page to Amendment No. 1 to Fourth Amended and Restated Voting Agreement 

 PURCHASER: 

 

	
	 /s/ Gerald W. Blakeley, Jr.

	Gerald W. Blakeley, Jr.

  
 Signature
Page to Amendment No. 1 to Fourth Amended and Restated Voting Agreement 

 PURCHASER: 

 

	
	 /s/ Gerald W. Blakeley, III

	Gerald W. Blakeley, III

  
 Signature
Page to Amendment No. 1 to Fourth Amended and Restated Voting Agreement 

							
	PURCHASER:	 		 	D2 INVESTMENT LLC
				
		 		 	By:	 	 /s/ Chris Kryder

		 		 		 	Chris Kryder
		 		 		 	Manager

  
 Signature
Page to Amendment No. 1 to Fourth Amended and Restated Voting Agreement 

 PURCHASER: 

 

	
	 /s/ Peter T. Scardino

	Peter T. Scardino

  
 Signature
Page to Amendment No. 1 to Fourth Amended and Restated Voting Agreement 

 PURCHASER: 

 

	
	 /s/ Edwin Darracott Vaughan, Jr.

	Edwin Darracott Vaughan, Jr.

  
 Signature
Page to Amendment No. 1 to Fourth Amended and Restated Voting Agreement 

							
	PURCHASER:	 		 		 	JOHN T. CONNOR JR. AND SUSAN SCHOLLE CONNOR, tenants by the entirety
				
		 		 		 	  

		 		 		 	John T. Connor Jr.
				
		 		 		 	  

		 		 		 	Susan Scholle Connor

  
 Signature
Page to Amendment No. 1 to Fourth Amended and Restated Voting Agreement 

 PURCHASER: 

 

	
	 /s/ Jeffrey B. Larson

	Jeffrey B. Larson

  
 Signature
Page to Amendment No. 1 to Fourth Amended and Restated Voting Agreement 

 PURCHASER: 

 

	
	 /s/ Megan Kelleher

	Megan Kelleher

  
 Signature
Page to Amendment No. 1 to Fourth Amended and Restated Voting Agreement 

									
	PURCHASER:	 		 		 	RUSNANO
		 		 		 	an open joint stock company organized and existing under the laws of the Russian Federation
					
		 		 		 	By:	 	 /s/ Andrey Malyshev

		 		 		 	Name:	 	Andrey Malyshev
		 		 		 	Title:	 	Deputy Chairman of the Management Board

  
 Signature
Page to Amendment No. 1 to Fourth Amended and Restated Voting Agreement 

 AMENDMENT NO. 2 

TO 

FOURTH AMENDED AND RESTATED VOTING AGREEMENT 
 THIS AMENDMENT NO. 2 TO FOURTH AMENDED AND RESTATED VOTING AGREEMENT (this “Amendment”) is made and entered into as of January 23, 2013, by and among BIND Biosciences, Inc., a
Delaware corporation (the “Company”), and the undersigned stockholders of the Company.  

WHEREAS, the Company and certain stockholders of the Company entered into that certain Fourth Amended and Restated Voting
Agreement, dated as of November 7, 2011 (as amended to date, the “Agreement”); 
 WHEREAS, pursuant
to Section 12.5 of the Agreement, the Agreement may be amended by written agreement of (i) the Company, (ii) the Founders holding shares representing a majority of the voting power of the Shares then held by all of the Founders,
provided that, for purposes of this provision, the Shares held by the trusts listed on Schedule C of the Agreement shall be included in the calculation of Shares held by their respective settlors and (iii) Purchasers holding shares (other
than Series BRN Preferred Stock) representing at least sixty-five percent (65%) of the voting power of the Shares (other than shares of Series BRN Preferred Stock) then held by all of the Purchasers (collectively, the “Requisite
Parties”); 
 WHEREAS, the Company and the undersigned stockholders of the Company constitute the Requisite
Parties; and 
 WHEREAS, the parties hereto desire to amend the Agreement as set forth herein. 

NOW, THEREFORE, for good and valuable consideration, the receipt and adequacy of which are hereby acknowledged, the parties hereto
hereby covenant and agree to be bound as follows: 
 Section 1. Capitalized Terms. Capitalized terms used herein and
not otherwise defined herein shall have the respective meanings assigned to them in the Agreement. 
 Section 2.
Amendments. 
 (a) The following text shall be added as a new paragraph at the end of Section 1.1 of the Agreement:

 “Notwithstanding anything to the contrary herein, if any person or entity (or its Affiliate) has (i) the right to
appoint one or more Preferred Directors pursuant to Section 1.1(b) above and (ii) its respective shares of Preferred Stock converted into Common Stock pursuant to Section 3.3A of Article Fourth of the Company Charter (as
defined below), then such person, entity or Affiliate, as applicable, shall forfeit its respective rights to appoint any Preferred Director pursuant to Section 1.1(b) above.” 

(b) Section 1.2 of the Agreement is hereby amended by adding the following as a new subsection (e) thereto: 

“(e) Notwithstanding anything to the contrary herein, in the event of the conversion into Common Stock of the shares of Preferred
Stock held by any Purchaser or its Affiliates pursuant to Section 3.3A of Article Fourth of the Company Charter (as defined below), the rights of such Purchaser under this Section 1.2 shall terminate automatically.” 

 (c) The following is added as a new sentence at the end of Section 8.1 of the
Agreement: 
 “Following a permitted joinder to this Agreement by such transferee, and upon such joinder, the Company shall
update the Schedules and signature pages hereto as needed to reflect the addition of such Stockholder as a party hereto.” 

(d) The third sentence of Section 12.5 of the Agreement is hereby amended and restated in its entirety to read as follows:

 “Notwithstanding anything to the contrary herein, this Agreement may be amended by the Company without the consent of any
of the other parties hereto to (A) add as a party hereto and include information regarding and otherwise accommodate an additional purchaser of shares of the Series D Preferred Stock or Series BRN Preferred Stock (including a Co-Investor)
pursuant to the Purchase Agreement, as may be amended from time to time; provided that any such amendment does not materially and adversely affect the rights of any Purchaser under this Agreement (it being agreed that the issuance of additional
shares of capital stock in accordance with the Purchase Agreement, as may be amended or modified from time to time in accordance with its terms, and the other Financing Agreements, each as may be amended or modified from time to time in accordance
with its respective terms, shall not be deemed to affect the Purchasers under this Agreement) and (B) add as a party hereto and include information regarding and otherwise accommodate any purchaser of shares of Series D Preferred Stock pursuant
to the Series D Preferred Stock Purchase Agreement dated as of January 23, 2013, among the Company and the purchasers named therein, as may be amended from time to time (the “Series D Preferred Stock Extension Purchase
Agreement”).” 
 (e) Section 12.8 of the Agreement is hereby amended and restated in its entirety to read as
follows: 
 “12.8 Additional Purchasers. Notwithstanding Section 12.5, any person or entity that
purchases (i) Series BRN Preferred Stock as a Co-Investor (as defined in the Purchase Agreement) under the Purchase Agreement or (ii) Series D Preferred Stock under the Series D Preferred Stock Extension Purchase Agreement, unless already
a party to this Agreement, shall become a party to this Agreement by executing and delivering to the Company a counterpart signature page to this Agreement, and thereupon shall be deemed a “Purchaser” for all purposes of this Agreement,
and the Company shall amend Schedule A hereto to add the name and address of such Purchaser. No such accession instrument shall be effective unless and until accepted in writing by the Company. No action or consent by the Purchasers,
Founders, Executive Officers or Other Stockholders shall be required for such joinder to this Agreement by such Co-Investor or such other purchaser or any aforesaid amendment of Schedule A, so long as such Co-Investor or such other purchaser
has agreed in writing to be bound by all of the obligations as a “Purchaser” hereunder.” 
 (f) Schedule C of the
Agreement is hereby amended and restated in its entirety to read as set forth on Schedule C of this Amendment. 

 Section 3. No Other Amendments; Conflicts. No term or provision of the Agreement
shall be affected by this Amendment, unless specifically set forth herein and any term or provision not affected by this Amendment shall remain in full force and effect following the date hereof. In the event of a conflict between the terms of the
Agreement and the terms of this Amendment, the terms of this Amendment shall control. 
 Section 4. Governing Law.
This Amendment shall be governed by, and construed and enforced in accordance with, the General Corporation Law of the State of Delaware as to matters within the scope thereof, and as to all other matters shall be governed by, and construed and
enforced in accordance with, the internal laws of the State of New York, without regard to conflict of law principles that would result in the application of any law other than the law of the State of New York. 

Section 5. Captions; Pronouns. All articles and section headings or captions contained in this Amendment are inserted only as
a matter of convenience and for reference and in no way define, limit, extend or describe the scope of this Amendment or the intent of any provision thereof. 
 Section 6. Severability. If any provision of this Amendment or application to any party or circumstance shall be determined by any court of competent jurisdiction to be invalid or
unenforceable to any extent, the remainder of this Amendment or the application of such provision to any other party or circumstances shall not be affected thereby, and each provision shall be valid and shall be enforced to the fullest extent
permitted by law. 
 Section 7. Counterparts. This Amendment may be executed in multiple counterparts, each of which
shall be deemed an original, but all of which taken together shall constitute one and the same instrument. The exchange of copies of this Amendment and of signature pages by facsimile transmission or other electronic means shall constitute effective
execution and delivery of this Amendment as to the parties and may be used in lieu of the original Amendment for all purposes. 

[Signature Page Follows] 

 IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be executed as
of the date first written above. 
  

			
	BIND BIOSCIENCES, INC.
		
	By:	 	 /s/ Scott Minick

	Name:	 	Scott Minick
	Title:	 	President & Chief Executive Officer

  
 Signature
Page to Amendment No. 2 to Fourth Amended and Restated Voting Agreement 

							
	FOUNDERS:	 		 		 	 /s/ Omid Farokhzad

		 		 		 	Omid Farokhzad
				
		 		 		 	  

		 		 		 	Paul Goldenheim
				
		 		 		 	 /s/ Robert S. Langer, Jr.

		 		 		 	Robert S. Langer, Jr.
				
	EXECUTIVE OFFICERS:	 		 		 	 /s/ Scott Minick

		 		 		 	Scott Minick

  
 Signature
Page to Amendment No. 2 to Fourth Amended and Restated Voting Agreement 

 OTHER STOCKHOLDERS: 

 

			
	SHADI K. ARYANPOUR AS TRUSTEE OF SAF-BND TRUST
		
	By:	 	 /s/ Shadi K. Aryanpour

	Shadi K. Aryanpour, Trustee
	
	REZA ARYANPOUR AS TRUSTEE OF OCF-BND TRUST
		
	By:	 	 /s/ Reza Aryanpour

	Reza Aryanpour, Trustee
	
	 /s/ Shoku Ordukhani Kashi

	Shoku Ordukhani Kashi

  
 Signature
Page to Amendment No. 2 to Fourth Amended and Restated Voting Agreement 

											
	PURCHASERS:	 		 	POLARIS VENTURE PARTNERS V, L.P.
		 		 	By:	 	POLARIS VENTURE MANAGEMENT CO. V, L.L.C., its General Partner
						
		 		 		 		 	By:	 	 /s/ William E. Bilodeau

		 		 		 		 	William E. Bilodeau
		 		 		 		 	Attorney-in-fact
			
		 		 	POLARIS VENTURE PARTNERS ENTREPRENEURS’ FUND V, L.P.
				
		 		 	By:	 	POLARIS VENTURE MANAGEMENT CO. V, L.L.C., its General Partner
						
		 		 		 		 	By:	 	 /s/ William E. Bilodeau

		 		 		 		 	William E. Bilodeau
		 		 		 		 	Attorney-in-fact
			
		 		 	POLARIS VENTURE PARTNERS FOUNDERS’ FUND V, L.P.
				
		 		 	By:	 	POLARIS VENTURE MANAGEMENT CO. V, L.L.C., its General Partner
						
		 		 		 		 	By:	 	 /s/ William E. Bilodeau

		 		 		 		 	William E. Bilodeau
		 		 		 		 	Attorney-in-fact
			
		 		 	POLARIS VENTURE PARTNERS SPECIAL FOUNDERS’ FUND V, L.P.
				
		 		 	By:	 	POLARIS VENTURE MANAGEMENT CO. V, L.L.C., its General Partner
						
		 		 		 		 	By:	 	 /s/ William E. Bilodeau

		 		 		 		 	William E. Bilodeau
		 		 		 		 	Attorney-in-fact

  
 Signature
Page to Amendment No. 2 to Fourth Amended and Restated Voting Agreement 

											
	PURCHASER:	 		 	FLAGSHIP VENTURES FUND 2004, L.P.
				
		 		 	By:	 	FLAGSHIP VENTURES GENERAL PARTNER LLC, its General Partner
						
		 		 		 		 	By:	 	 /s/ Noubar Afeyan

		 		 		 		 	Noubar Afeyan
		 		 		 		 	Managing Partner and CEO

  
 Signature
Page to Amendment No. 2 to Fourth Amended and Restated Voting Agreement 

							
	PURCHASER:	 		 	ARCH VENTURE FUND VII, L.P.
				
		 		 	By:	 	ARCH VENTURE PARTNERS VII, L.P.
		 		 	Its:	 	General Partner
				
		 		 	By:	 	ARCH VENTURE PARTNERS VII, LLC
		 		 	Its:	 	General Partner
				
		 		 	By:	 	 /s/ Keith L. Crandell

		 		 	Its:	 	Managing Director

  
 Signature
Page to Amendment No. 2 to Fourth Amended and Restated Voting Agreement 

							
	PURCHASER:	 		 	NANODIMENSION, L.P.
				
		 		 	By:	 	NanoDimension Management Limited, its General Partner
				
		 		 	By:	 	 /s/ Jonathan Nicholson

		 		 		 	Jonathan Nicholson, Director

  
 Signature
Page to Amendment No. 2 to Fourth Amended and Restated Voting Agreement 

							
	PURCHASER:	 		 	DHK INVESTMENTS, LLC
				
		 		 	By:	 	 /s/ David H. Koch

		 		 		 	David H. Koch
		 		 		 	Manager

  
 Signature
Page to Amendment No. 2 to Fourth Amended and Restated Voting Agreement 

 PURCHASER: 

 

	
	 /s/ Peter W. Doelger

	Peter W. Doelger

  
 Signature
Page to Amendment No. 2 to Fourth Amended and Restated Voting Agreement 

					
	PURCHASER:	 		 	DOELGER FAMILY 2006 TRUST
		 		 	FBO EMILY M. DOELGER
			
		 		 	 /s/ Bruce A. Haverberg

		 		 	Bruce A. Haverberg, Trustee
			
		 		 	DOELGER FAMILY 2006 TRUST
		 		 	FBO MATTHEW DOELGER
			
		 		 	 /s/ Bruce A. Haverberg

		 		 	Bruce A. Haverberg, Trustee
			
		 		 	HEE-JEAN KIM 2007 TRUST
			
		 		 	 /s/ Bruce A. Haverberg

		 		 	Bruce A. Haverberg, Trustee

  
 Signature
Page to Amendment No. 2 to Fourth Amended and Restated Voting Agreement 

 PURCHASER: 

 

	
	 /s/ Dimitris Bertsimas

	Dimitris Bertsimas

  
 Signature
Page to Amendment No. 2 to Fourth Amended and Restated Voting Agreement 

									
	PURCHASER:	 		 	ENDEAVOUR II L.P.
				
		 		 	By:	 	ENDEAVOUR PARTNERS GP LIMITED
		 		 		 	its General Partner
				
		 		 	By:	 	 /s/ John Bridle

		 		 		 	Name:	 	John Bridle
		 		 		 	Title:	 	Director

  
 Signature
Page to Amendment No. 2 to Fourth Amended and Restated Voting Agreement 

 PURCHASER: 

 

	
	 /s/ Gerald W. Blakeley, Jr.

	Gerald W. Blakeley, Jr.

  
 Signature
Page to Amendment No. 2 to Fourth Amended and Restated Voting Agreement 

 PURCHASER: 

 

	
	 /s/ Gerald W. Blakeley, III

	Gerald W. Blakeley, III

  
 Signature
Page to Amendment No. 2 to Fourth Amended and Restated Voting Agreement 

							
	PURCHASER:	 		 	D2 INVESTMENT LLC
				
		 		 	By:	 	 /s/ Chris Kryder

		 		 		 	Chris Kryder
		 		 		 	Manager

  
 Signature
Page to Amendment No. 2 to Fourth Amended and Restated Voting Agreement 

 PURCHASER: 

 

	
	 /s/ Peter T. Scardino

	Peter T. Scardino

  
 Signature
Page to Amendment No. 2 to Fourth Amended and Restated Voting Agreement 

 PURCHASER: 

 

	
	 /s/ Edwin Darracott Vaughan, Jr.

	Edwin Darracott Vaughan, Jr.

  
 Signature
Page to Amendment No. 2 to Fourth Amended and Restated Voting Agreement 

					
	PURCHASER:	 		 	JOHN T. CONNOR JR. AND SUSAN SCHOLLE CONNOR, tenants by the entirety
			
		 		 	 /s/ John T. Connor Jr.

		 		 	John T. Connor Jr.
			
		 		 	 /s/ Susan Scholle Connor

		 		 	Susan Scholle Connor

  
 Signature
Page to Amendment No. 2 to Fourth Amended and Restated Voting Agreement 

 PURCHASER: 

 

	
	 /s/ Jeffrey B. Larson

	Jeffrey B. Larson

  
 Signature
Page to Amendment No. 2 to Fourth Amended and Restated Voting Agreement 

 PURCHASER: 

 

	
	 /s/ Megan Kelleher

	Megan Kelleher

  
 Signature
Page to Amendment No. 2 to Fourth Amended and Restated Voting Agreement 

							
	PURCHASER:	 		 	RUSNANO
		 		 	an open joint stock company organized and existing under the laws of the Russian Federation
				
		 		 	By:	 	 /s/ Andrey Rappoport

		 		 	Name:	 	Andrey Rappoport
		 		 	Title:	 	First Deputy Chairman of the Management Board

  
 Signature
Page to Amendment No. 2 to Fourth Amended and Restated Voting Agreement 

 SCHEDULE C 
 Other Stockholders 
 Pamela Basto 
 125 Liberty Rd #3 
 Somerville, MA 02144 
 Chris Cannizzaro 
 413 North Avenue 
 Weston, MA 02493 
 Jianjun Cheng 
 2304 Lynwood Drive 
 Champaign, IL 61821 

Abraham J. Domb 
 16 Migdal Eder
Street 
 EFRAT, 90435 Israel 

Ruxandra Gref 
 14 rue Moulin Fidel,
apt G62 
 92350 Plessis Robinson, France 
 Sangyong Jon 
 Dept. of Life Science, GIST 
 1-Oryong dong, Bukgu 
 Gwangju 500-71, Republic of Korea 

Shoku Ordukhani Kashi 
 OCF-BND TRUST

 c/o Reza Aryanpour, Trustee 
 19
Heron Drive 
 Mill Valley, CA 94941 

SAF-BND TRUST 
 c/o Shadi K. Aryanpour,
Trustee 
 15 Laura Road 
 Waban, MA
02468 
 Michael D. Langer Trust u/d/t 12/14/95 
 c/o Stephanie K. Meilman, Trustee 
 Law Office of Meilman & Costa, P.C. 

70 Wells Avenue, Suite 200 
 Newton, MA
02459 

 Rohit Karnik 
 931 Massachusetts Ave., Apt. 7 
 Cambridge, MA 02139 

Alireza Khademhosseini 
 16 Trowbridge
Street, #32 
 Cambridge, MA 02138 

Maria Teresa Peracchia 
 18 Rue Cuvier

 75005 Paris, France 
 Aleksandar
Filip Radovic-Moreno 
 1055 Crabapple Drive 
 State College, PA 16801 
 Benjamin A. Teply 

5109 Nicholas St., 
 Omaha, NE 68132-1433

 Liangfang Zhang 
 6191 Blue
Dawn Trail 
 San Diego, CA 92130 

Susan K. Langer Trust u/d/t 12/14/95 
 c/o
Stephanie K. Meilman, Trustee 
 Law Office of Meilman & Costa, P.C. 
 70 Wells Avenue, Suite 200 
 Newton, MA 02459 

Samuel A. Langer Trust u/d/t 12/14/95 
 c/o
Stephanie K. Meilman, Trustee 
 Law Office of Meilman & Costa, P.C. 
 70 Wells Avenue, Suite 200 
 Newton, MA 02459

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