Document:

Executive Employment Agreement

 ISTA PHARMACEUTICALS, INC. 
 EXECUTIVE EMPLOYEE AGREEMENT 
 This Executive Employee Agreement
(“Agreement”) is entered into as of March 13, 2006 (the “Effective Date”), by and between Vicente Anido, Jr. Ph.D. (“Executive”) and ISTA Pharmaceuticals, Inc., a Delaware corporation (the “Company”).

 WHEREAS, the Company desires to continue to employ Executive to provide personal services to the Company, and wishes to provide
Executive with certain compensation and benefits in return for these services; and 
 WHEREAS, Executive wishes to continue to be
employed by the Company and provide personal services to the Company in return for certain compensation and benefits, including the benefits provided under this Agreement; and 
 WHEREAS, Executive and the Company wish this Agreement to replace and supercede any other agreements or arrangements existing as of the Effective
Date between Executive and the Company providing for severance or other benefits upon termination of employment including but not limited to the Employment Agreement dated December 21, 2001 (collectively, the “Prior Security
Agreements”). 
 NOW, THEREFORE, in consideration of the mutual promises and covenants contained herein, it is hereby agreed by
and between the parties hereto as follows: 
 1. EMPLOYMENT BY THE COMPANY. Subject to the terms and conditions set forth herein, the
Company agrees to employ Executive to render full time services as the Company’s Chief Executive Officer and President and in such other capacities as the Company’s Board of Directors (“Board”) may assign. Executive hereby
accepts employment based on the terms and conditions set forth herein effective as of the Effective Date. In this position, Executive shall perform such duties as are assigned by the Board. During Executive’s employment with the Company,
Executive will devote Executive’s best efforts and substantially all of Executive’s business time and attention to the business of the Company. Executive shall abide by the general employment policies and procedures of the Company, except
that wherever the terms of this Agreement may differ from or are in conflict with the Company’s general employment policies or procedures, this Agreement shall control. 
 2. COMPENSATION. 
 2.1 Salary. For services to be rendered hereunder, Executive shall receive a base annual salary as set forth in Section 1 of the Compensation and Severance Terms Schedule, attached hereto as Exhibit A. Executive will be
considered annually for adjustments in base salary. Any such adjustments will be subject to review and approval by the Compensation Committee of the Board and/or the Board, as appropriate. 
 2.2 Bonus. Executive shall be eligible to participate in the Company’s bonus plan at the executive level. Notwithstanding the
foregoing, no bonus is guaranteed to Executive. The Company shall have the sole discretion to determine whether Executive is entitled to any such 

  

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bonus and to determine the amount of the bonus. Any bonus is subject to the approval of the Compensation Committee of the Board and/or the Board, as
appropriate. To be eligible to receive any bonus, Executive must be employed by the Company throughout the entire fiscal year or as otherwise set forth in the applicable bonus plan and be employed at the time the bonus is paid out. The current
target level of such discretionary bonus for Executive is set forth in Section 2 of Exhibit A attached hereto. The Company retains the authority to review, grant, deny or revise any bonus or target level in its sole discretion.

 2.3 Equity Awards. Subject to approval of the Board or the Compensation Committee of the Board, as appropriate,
Executive will be eligible to receive grants of stock options, restricted stock or other equity awards as may from time to time be granted or awarded, pursuant to the terms and conditions set forth in the applicable equity award agreement and plan
documents, copies of which will be made available upon Executive’s request. For the purposes of this Agreement, all stock options, restricted stock or other equity awards granted to Executive by the Company hereunder, or granted in the future,
shall be referred to hereinafter as the “Equity Awards.” 
 2.4 Vacation, Holiday Pay and Sick Leave.
Executive shall be entitled to four (4) weeks of paid vacation each year. Any earned but unused vacation shall be accrued and may be used by Executive in any subsequent year. Upon termination of Executive’s employment for any reason,
Executive shall receive vacation pay for all earned but unused vacation, calculated at his base salary rate in effect at the time of termination. The Company shall also provide Executive with holiday pay and paid sick leave as provided by the
Company to its other executive employees of comparable stature. Any earned but unused sick leave shall be accrued and may be used by Executive in any subsequent year; provided that, upon termination of Executive’s employment for any reason,
Executive shall receive no pay or other compensation for any accrued but unused sick leave. Notwithstanding the foregoing, vacation, holiday pay and sick leave do not accrue while Executive is on unpaid leave. 
 2.5 Standard Company Benefits. Executive shall receive all other employment benefits for which Executive is eligible under the
terms and conditions of the standard Company benefits plans (e.g., health and disability insurance, 401(k) retirement plan, etc.) and other benefits and incentives which may be in effect from time to time and provided by the Company to employees at
levels similar to Executive. Employment benefits, including but not limited to vacation, holiday pay, sick leave, paid insurance premiums, and other benefits do not accrue or continue during an unpaid leave, unless otherwise required by law.

 3. PROPRIETARY INFORMATION AND INVENTIONS. 
 Executive shall comply with the terms of the Employee Proprietary Information and Inventions Agreement, between the Company and Executive, in the form currently entered into and as amended from time to time, and/or
such other agreement(s) between Executive and the Company protecting the confidential and proprietary information and/or inventions of the Company as may be entered into after the date hereof (collectively, the “Employee Proprietary Information
and Inventions Agreement”). The terms of the Employee Proprietary Information and Inventions Agreement are incorporated herein by this reference. Notwithstanding any termination or expiration of this Agreement or termination of Executive’s
employment, Executive agrees to continue to comply with the terms of the Employee Proprietary Information and Inventions Agreement. 
  

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 4. OUTSIDE ACTIVITIES. 
 4.1 Activities. Except with the prior written consent of the Board, Executive will not during Executive’s employment with the
Company undertake or engage in any other employment, self-employment, occupation, consulting, or business enterprise, other than ones in which Executive is a passive investor. Without limiting the foregoing, Executive may not serve as a member of
the board of directors of any public or private for-profit company, except with the prior written consent of the Board. Executive’s board memberships as of the Effective Date disclosed in writing by Executive to the Board are hereby approved.
Executive may engage in civic and not-for-profit activities so long as such activities do not materially interfere with the performance of Executive’s duties hereunder. Executive will not during Executive’s employment with the Company or
thereafter publicly or privately disparage the Company or any of its subsidiaries, or their respective past or present products, officers, directors, employees, agents or customers. 
 4.2 Investments and Interests. During Executive’s employment by the Company, Executive agrees not to acquire, assume or
participate in, directly or indirectly, any position, investment or interest which is adverse to or in conflict with the interests of the Company, its current and anticipated business or prospects, financial or otherwise. By way of clarification,
nothing contained in this Agreement shall prevent Executive from holding, for investment purposes only, no more than one percent (1%) of the capital stock of any publicly traded company. 
 4.3 Non-Competition. During Executive’s employment by the Company, except on behalf of the Company, Executive will not
directly or indirectly, whether as an officer, director, employee, stockholder, partner, proprietor, associate, representative, consultant, contractor, or in any other capacity whatsoever engage in, become financially interested in, be employed by
or have any business connection with any other person, corporation, firm, partnership or other entity whatsoever that competes with the Company, anywhere in the world, in any line of business engaged in (or planned to be engaged in) by the Company.

 5. OTHER AGREEMENTS. 
 Executive represents and warrants that Executive’s employment by the Company will not conflict with and will not be constrained by any prior agreement or relationship with any third party. Executive represents and warrants that
Executive will not disclose to the Company or use on behalf of the Company any trade secrets or other confidential information of any third party except in accordance with an agreement between the Company and any such third party. During
Executive’s employment by the Company, Executive may use, in the performance of Executive’s duties, all information generally known and used by persons with training and experience comparable to Executive’s own and all information
which is common knowledge in the industry or otherwise legally in the public domain. 
 6. TERMINATION OF EMPLOYMENT. 
 6.1 At Will Employment. Executive’s relationship with the Company is at will. The Company shall have the right to terminate
Executive’s employment with the Company at any time with or without Cause and with or without advance notice. 
 6.2
Termination by Company for Cause. The Company may terminate Executive’s employment for Cause at any time effective on written notice to Executive. In the event 

  

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of a termination for Cause, the Company’s sole obligation and liability to Executive shall be to pay Executive any unpaid salary, together with any
unused vacation accrued to the effective date of such termination. Executive will not be entitled to severance benefits or any other compensation of any kind resulting from Executive’s termination for Cause. For purposes of this Agreement,
“Cause” shall mean any of the following events, as determined by the Company: (i) Executive’s conviction of any felony; (ii) Executive’s deliberate attempt to do injury to the Company; (iii) dishonest or fraudulent
conduct by Executive; (iv) Executive’s misconduct, gross negligence, material violation of Company policy, or material breach of this Agreement; or (v) Executive’s unsatisfactory performance of Executive’s duties to the
Company which, with respect to this clause (v), Executive fails to correct within thirty (30) days after Executive is given written notice by the Board. 
 6.3 Termination by Company Without Cause. The Company shall be entitled at any time to terminate Executive’s employment
without Cause, effective upon written notice to Executive. If the Company terminates Executive’s employment at any time without Cause, Executive shall be entitled to those severance benefits specifically set forth in Section 3.1 of the
Compensation and Severance Terms Schedule, attached hereto as Exhibit A. 
 6.4 Executive’s Voluntary
Resignation. Executive may terminate Executive’s employment with the Company at any time. In the event Executive voluntarily terminates Executive’s employment other than for Good Reason involving a Change in Control Termination as
provided in Section 7, the Company’s sole obligation and liability to Executive shall be to pay Executive any unpaid salary, together with any accrued, unused vacation, through the effective day of resignation. Executive will not be
entitled to severance benefits or any other compensation of any kind resulting from Executive’s voluntary termination. 
 6.5 Termination for Death or Disability. Executive’s employment with the Company will be terminated in the event of Executive’s death, or any illness, injury, disability or other incapacity that renders Executive physically
or mentally unable to perform the essential duties of Executive’s job. The Company acknowledges its obligations under all leave of absence laws, including the California Family Rights Act and the federal Family and Medical Leave Act, and, to
the extent provided by these and other applicable laws, will provide reasonable accommodation for any known disability of an otherwise qualified employee, unless undue hardship would result. In the event that Executive’s employment with the
Company is terminated for death or disability as described in this Section 6.5, Executive or Executive’s heirs, successors, and assigns shall not receive any severance benefits or other compensation other than payment of accrued salary and
vacation and such other benefits as may be expressly required in such event by applicable law or the terms of applicable benefit plans. 
 6.6 Cessation of Severance Benefits. If Executive violates any provision of Sections 3 or 4 of this Agreement or the Employee Proprietary Information and Inventions Agreement, either during employment or
thereafter, then, notwithstanding anything herein to the contrary, the Company shall have the right upon written notice to Executive to immediately cease payment of any severance benefits being provided to Executive, and Executive will not be
entitled to any further compensation from the Company. 
  

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 7. CHANGE IN CONTROL. 
 7.1 Definitions. 
 (a) Definition of “Change in Control.” For purposes of this Agreement, “Change in Control” shall mean the occurrence of any of the following events: 
 (i) The acquisition, directly or indirectly, in one transaction or a series of related transactions, by any person or group (within the
meaning of Section 13(d)(3) or 14(d)(2) of the Exchange Act) of the beneficial ownership of securities of the Company possessing more than fifty percent (50%) of the total combined voting power of all outstanding securities of the Company;

 (ii) A merger or consolidation of the Company with any other entity, whether or not the Company is the surviving entity in
such transaction, except for a transaction in which the holders of the outstanding voting securities of the Company immediately prior to such merger or consolidation hold as a result of holding Company securities prior to such transaction, in the
aggregate, securities possessing more than fifty percent (50%) of the total combined voting power of all outstanding voting securities of the Company or of the surviving entity (or the parent of the surviving entity) immediately after such
merger or consolidation; 
 (iii) The sale, transfer or other disposition (in one transaction or a series of related
transactions) of all or substantially all of the assets of the Company; or 
 (iv) The approval by the stockholders of a plan
or proposal for the liquidation or dissolution of the Company. 
 (b) Definition of “Good Reason.” For
purposes of this Agreement, “Good Reason” shall mean any one of the following events which occurs on or after the Effective Date and after a Change in Control: (i) any material reduction of Executive’s then existing annual base
salary; (ii) any material reduction in the package of benefits and incentives, taken as a whole, provided to Executive (except that employee contributions may be raised to the extent of any cost increases imposed by third parties) or any action
by the Company which would materially and adversely affect Executive’s participation or reduce Executive’s benefits under any such plans, except to the extent that such benefits and incentives of all other executive officers of the Company
are similarly reduced; (iii) any material diminution of Executive’s duties and responsibilities, taken as a whole, excluding for this purpose an isolated, insubstantial or inadvertent action not taken in bad faith which is remedied by the
Company immediately after notice thereof is given by Executive; (iv) any material breach by the Company of its obligations under this Agreement; (v) any failure by the Company to obtain the assumption of this Agreement by any successor or
assign of the Company; or (vi) any requirement that Executive relocate to a work site that would increase Executive’s one-way commute distance by more than fifty (50) miles from Executive’s then principal residence, unless
Executive accepts such relocation opportunity. 
 7.2 Termination After a Change in Control. In the event
Executive’s employment with the Company is terminated without Cause, or Executive resigns for Good Reason, within twenty-four (24) months following a Change in Control (a “Change in Control Termination”), then Executive shall be
eligible for severance benefits as set forth in Section 3.2 of Exhibit A, attached hereto. Executive may resign Executive’s employment for Good Reason so long as Executive tenders his resignation to the Company within sixty
(60) days after the occurrence of the event which forms the basis for Executive’s termination for Good Reason. 
  

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 7.3 Parachute Payments. In the event that the severance, acceleration of Equity
Awards and other benefits provided for in this Agreement (“Agreement Benefits”), together with benefits otherwise payable to Executive, (i) constitute a “parachute payment” within the meaning of Section 280G (as it may
be amended or replaced) of the Internal Revenue Code of 1986, as amended or replaced (the “Code”), and (ii) but for this Section 7.3, would be subject to the excise tax imposed by Section 4999 (as it may be amended or
replaced) of the Code (the “Excise Tax”), then Executive’s Agreement Benefits shall be either: 
 (a)
provided to Executive in full, or 
 (b) provided to Executive only as to such lesser extent that would result in no
portion of such Agreement Benefits being subject to the Excise Tax, 
 whichever of the foregoing amounts, taking into account the applicable federal, state
and local income taxes and the Excise Tax, results in the receipt by Executive, on an after-tax basis, of the greatest amount of benefits, notwithstanding that all or some portion of such Agreement Benefits may be taxable under the Excise Tax.

 Unless the Company and Executive otherwise agree in writing, any determination required under this Section 7.3 shall be made in writing in good faith
by the Company’s independent registered accounting firm or such other nationally or regionally recognized accounting firm selected by the Company (the “Accountants”), whose determination shall be conclusive and binding upon Executive
and the Company for all purposes. In the event of a reduction in benefits hereunder, Executive shall be given the choice, subject to approval by the Company, of which benefits to reduce; provided that such reduction achieves the result specified in
clause (b) of this Section 7.3. For purposes of making the calculations required by this Section 7.3, the Accountants may make reasonable assumptions and approximations concerning applicable taxes and may rely on reasonable, good
faith interpretations concerning the application of the Code. The Company and Executive shall furnish to the Accountants such information and documents as the Accountants may reasonably request in order to make a determination under this
Section 7.3. The Company shall bear all costs the Accountants may reasonably incur in connection with any calculations contemplated by this Section 7.3. 
 8. RELEASE. In exchange for the severance benefits referenced in this Agreement and in Exhibit A attached hereto to which Executive would not otherwise be entitled, in the event of a termination without
Cause or a Change in Control Termination, Executive shall execute and enter into a release of claims against the Company in the form provided by the Company (the “Release”) upon Executive’s termination of employment. Unless the
Release is executed by Executive and delivered to the Company within the time limits specified in the Release, then notwithstanding anything herein to the contrary, Executive shall not receive any of the severance compensation or benefits provided
under this Agreement; acceleration, if any, of Executive’s Equity Awards as provided in this Agreement shall not apply; and Executive’s Equity Awards in such event may be exercised following the date of Executive’s termination only to
the extent provided under their original terms in accordance with the applicable equity plans and Equity Award agreements. 
 9. GENERAL
PROVISIONS. 
 9.1 Notices. Any notices provided hereunder must be in writing and shall be deemed effective upon
personal delivery (including, personal delivery by facsimile transmission) or the third day after mailing by first class mail, to the Company at its primary office location and to 

  

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Executive at Executive’s address as listed on the Company payroll (which address may be changed by written notice). 
 9.2 Severability. Whenever possible, each provision of this Agreement will be interpreted in such manner as to be effective and
valid under applicable law, but if any provision of this Agreement is held to be invalid or unenforceable in any respect under any applicable law or rule in any jurisdiction, such invalidity or unenforceability will not affect any other provision or
any other jurisdiction, and such invalid or unenforceable provision shall be reformed, construed and enforced in such jurisdiction so as to render it valid and enforceable consistent with the intent of the parties insofar as possible. 
 9.3 Waiver. If either party should waive any breach of any provisions of this Agreement, he or it shall not thereby be deemed to
have waived any preceding or succeeding breach of the same or any other provision of this Agreement. 
 9.4
Counterparts. This Agreement may be executed in separate counterparts, any one of which need not contain signatures of more than one party, but all of which taken together will constitute one and the same Agreement. 
 9.5 Headings. The headings of the sections hereof are inserted for convenience only and shall not be deemed to constitute a part
hereof nor to affect the meaning thereof. 
 9.6 Successors and Assigns. This Agreement is intended to bind and inure
to the benefit of and be enforceable by Executive, the Company and their respective successors, assigns, heirs, executors and administrators, except that Executive may not assign any of Executive’s duties or rights hereunder, without the
written consent of the Company. 
 9.7 Arbitration. To provide a mechanism for rapid and economical dispute resolution,
Executive and the Company agree that any and all disputes, claims, or causes of action, in law or equity, arising from or relating to Executive’s employment, compensation, this Agreement (including the Release upon which the payment of
severance benefits is conditioned) or the enforcement, performance, breach, or interpretation of this Agreement, will be resolved by final and binding arbitration held in Orange County, California and conducted by Judicial Arbitration &
Mediation Services/Endispute (“JAMS”), under its then-existing Rules and Procedures. Executive understands that final and binding arbitration will be the sole and exclusive remedy for any such claim or dispute between him and the Company
and its parent, subsidiary or affiliated companies or entities, and each of its and/or their employees, officers, directors or agents, and that, by agreeing to use arbitration to resolve such claims or disputes, both the Company and Executive agree
to forego any right each may have had to a jury trial. Both Executive and the Company will have the right to conduct reasonable discovery in such arbitration proceeding as determined by the arbitrator and as provided by the procedural rules
applicable to arbitration proceedings referenced above. In addition, both Executive and the Company will have the right to assert counterclaims and to bring motions otherwise available in civil actions, including for example, demurrers, motions for
summary judgment, motions for judgment, etc. Notwithstanding the foregoing, nothing in this Section 9.7 or in this Agreement shall prevent either Executive or the Company from seeking and obtaining injunctive relief in any court to prevent
irreparable harm from any breach or threatened breach of the provisions of Sections 3 or 4 of this Agreement or the Employee Proprietary Information and Inventions Agreement pending resolution of any arbitration hereunder. The provisions of this

  

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Section 9.7 shall survive the termination or expiration of this Agreement and termination of Executive’s employment and shall remain in full force
and effect thereafter. 
 9.8 Remedies. Executive’s duties under Sections 3 and 4 of this Agreement and the
Employee Proprietary Information and Inventions Agreement shall survive termination or expiration of this Agreement and termination of Executive’s employment with the Company. Executive acknowledges that a remedy at law for any breach or
threatened breach by Executive of the provisions of these Sections and the Employee Proprietary Information and Inventions Agreement would be inadequate, and that such a breach would cause irreparable harm to the Company; and Executive therefore
agrees that the Company shall be entitled to injunctive relief in case of any such breach or threatened breach. 
 9.9
Governing Law. All questions concerning the construction, validity and interpretation of this Agreement will be governed by the law of the State of California as applied to contracts made and to be performed entirely within California.

 10. TERM OF AGREEMENT. This Agreement shall become effective as of the Effective Date and shall remain in effect through the period
ending on the third anniversary of the Effective Date (the “Initial Term”) and shall automatically renew for successive one (1) year periods (the “Extended Term) unless the Company, in its sole discretion with or without reason,
provides written notice to Executive of non-renewal (a “Non-renewal Notice”) no later than sixty (60) days before the expiration date of the Initial Term or any Extended Term, in which case this Agreement shall expire upon on such
expiration date. As used herein, the “Term” shall mean the Initial Term and any Extended Term. Notwithstanding the foregoing, in the event a Change in Control occurs during the Term then the Term of this Agreement shall continue and may
not be terminated until the expiration of twenty-four (24) months after the Change in Control unless consented to in writing by Executive and the Company. Expiration or termination of the Term of this Agreement shall not relieve the parties of
any obligation accruing prior to such expiration or termination, including but not limited to any obligation of the Company to pay the severance and other benefits to Executive hereunder for any termination without Cause or a Change in Control
Termination which occurs prior to the expiration or termination of the Term of this Agreement. By way of clarification, a Non-renewal Notice shall not constitute a notice of termination of Executive’s employment and termination or expiration of
the Term of this Agreement shall not constitute termination of Executive’s employment resulting in any obligation of the Company to provide the severance benefits hereunder. The Company has no obligation to pay severance benefits to Executive
hereunder arising from any termination of Executive’s employment after the expiration or termination of the Term of this Agreement. The provisions of Sections 3, 4, 9, 10 and 11 of this Agreement shall survive the expiration or termination of
the Term of this Agreement. 
 11. ENTIRE AGREEMENT. This Agreement, together Exhibit A attached hereto, the Employee
Proprietary Information and Inventions Agreement, the Company’s Employee Handbook and Policies, as amended from time to time, and the applicable equity plans and Equity Award agreements, constitute the final, complete, and exclusive embodiment
of the entire agreement between Executive and the Company regarding the subject matter hereof and supersede any prior agreement, promise, representation, or statement, written or otherwise, between Executive and the Company with regard to this
subject matter including but not limited to the Prior Security Agreements. Without limiting the foregoing, the parties hereby terminate each and all Prior Security Agreements and Executive hereby releases and forever waives any rights Executive may
have against the Company under any Prior Security Agreement. This Agreement is entered into without reliance 

  

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on any promise, representation, statement or agreement other than those expressly contained or incorporated herein, and it cannot be modified or amended
except in a writing signed by Executive and a duly authorized officer of the Company. 
 12. RESIGNATION OF OTHER COMPANY POSITIONS.
In the event of any termination of Executive’s employment with the Company, unless otherwise agreed to in writing by Executive and the Board, Executive shall be deemed to have resigned as of the date of such termination as an officer and/or
director of the Company and any of its subsidiaries or affiliated companies for which Executive was serving in such capacities at the time of such termination. At the Company’s request, Executive agrees to execute concerning one or more such
positions so held resignation letter(s) in the form provided by the Company evidencing the foregoing. 
 IN WITNESS WHEREOF, the
parties have executed this Agreement effective as of the Effective Date above written. 
  

			
	 ISTA PHARMACEUTICALS, INC.

		
	 By:
	 	 /s/ Richard C. Williams

		
	 Its:
	 	 Chairman of the Board of Directors

	
	 EXECUTIVE

		
	  	 	 /s/ Vicente Anido, Jr., Ph.D.

		 	 Vicente Anido, Jr., Ph.D.

  

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 EXHIBIT A 
 COMPENSATION AND SEVERANCE TERMS SCHEDULE 
 1. BASE SALARY 
 For services to be rendered under this Agreement, Executive shall receive an annual gross base salary of four hundred twenty-six thousand one hundred
ninety-eight dollars ($426,198), payable in accordance with the Company’s standard payroll practices, and subject to adjustment as set forth in the Agreement. 
 2. BONUS 
 Executive’s annual bonus, if granted, shall be at a target level of up to fifty
percent 50% of Executive’s then current base salary. 
 3. SEVERANCE BENEFITS 
 3.1 Termination by Company Without Cause. If the Company terminates Executive’s employment at any time without Cause as
defined in Section 6.3 of the Agreement, the Company shall provide the following severance compensation and benefits to Executive after the effective date of the Release referenced in Section 8 of the Agreement: 
 (a) A severance payment equal to the sum of twelve (12) months of Executive’s then current base salary, payable (subject to
Section 4 below of this Exhibit A) by the Company in a lump sum, less legally required withholdings, within thirty (30) days after the effective date of the Release referenced in Section 8 of the Agreement; 
 (b) Health insurance premiums payable by the Company for continued health insurance coverage for Executive and all then currently insured
dependents for up to twelve (12) months after the termination date of Executive’s employment, provided that Executive makes a timely election to continue such coverage under COBRA; and provided further that, the Company’s obligation
to pay the monthly health insurance premiums for continued group medical insurance shall end when Executive becomes eligible for health insurance with a new employer, and Executive agrees to promptly notify the Company in writing of any such event
of eligibility; and 
 (c) Outplacement services for one year, at the Company’s expense up to a maximum amount of
twenty-five thousand dollars ($25,000), with a nationally recognized service selected by the Company. 
 Executive understands that Executive’s receipt
of the severance compensation and benefits specified in this Section 3.1 is conditioned upon Executive’s execution of the Release referenced in Section 8 of the Agreement, and further understands that the above lists the only
severance compensation and benefits to which Executive is entitled. 
  

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 3.2 Change in Control Termination. In the event of a Change in Control Termination
as defined in Section 7.2 of the Agreement, the Company shall provide the following severance compensation and benefits to Executive after the effective date of the Release referenced in Section 8 of the Agreement: 
 (a) A severance payment equal to the sum of (i) twenty-four (24) months of Executive’s then current base salary and
(ii) two (2) times Executive’s target bonus to be earned for the year in which termination occurs or two (2) times the bonus amount paid to Executive in the prior year, whichever is greater, payable (subject to Section 4
below of this Exhibit A) by the Company in a lump sum, less legally required withholdings, within thirty (30) days after the effective date of the Release referenced in Section 8 of the Agreement; and, 
 (b) Health insurance premiums payable by the Company for continued health insurance coverage for Executive and all then currently insured
dependents for up to twenty-four (24) months after the termination date of Executive’s employment, provided that Executive makes a timely election to continue such coverage under COBRA; and provided further that, the Company’s
obligation to pay the monthly health insurance premiums for continued group medical insurance shall end when Executive becomes eligible for health insurance with a new employer, and Executive agrees to promptly notify the Company in writing of any
such event of eligibility; and 
 (c) Outplacement services for one year, at the Company’s expense up to a maximum amount
of twenty-five thousand dollars ($25,000), with a nationally recognized service selected by the Company; and 
 (d) Any
unvested and outstanding Equity Awards held by Executive shall become one hundred percent (100%) vested as of the termination date of Executive’s employment. In this regard, without limiting the foregoing, but by way of clarification, all
stock options granted by the Company to Executive shall become fully vested and exercisable as of the termination date of Executive’s employment to the extent such stock options are outstanding and unexercisable at the time of such termination
and all stock subject to a right of repurchase by the Company (or its successor) that was purchased by Executive shall have such right of repurchase lapse with respect to all of the shares at the time of such termination. To the extent necessary to
effect the intent of this Agreement with respect to the Equity Awards, the applicable provisions of the Agreement and this Exhibit A shall be deemed an amendment to each agreement evidencing an Equity Award held by Executive. 
 Executive understands that Executive’s receipt of the severance compensation and benefits specified in this Section 3.2 is conditioned upon Executive’s
execution of the Release referenced in Section 8 of the Agreement, and further understands that the above lists the only severance compensation and benefits to which Executive is entitled. 
 4. SECTION 409A: DEFERRED COMPENSATION PLANS 
 4.1 Key Employee. Notwithstanding any other provision of the Agreement and this Exhibit A, as determined in the sole discretion of the Company, if Executive is a “Key Employee” within
the meaning of Section 416(i)(1) of the Code in the calendar year of Executive’s termination of employment with the Company, then the severance payment under Section 3.1(a) or Section 3.2(a), as applicable, shall be payable no
sooner than one hundred and eighty-three (183) calendar days following the effective date of Executive’s termination. 
 4.2 Section 409A Compliance. The intent of Executive and the Company is that the severance and other benefits payable to Executive under this Agreement not be deemed “deferred compensation” under
Section 409A of the Code. Executive and the Company agree to use reasonable best efforts to amend the terms of this Agreement from time to time as may be necessary to avoid the material imposition of penalties and additional taxes under
Section 409A(a)(1) of the Code; provided however, any such amendment will provide Executive substantially equivalent economic payments and benefits as set forth herein and will not in the aggregate, materially increase the cost to, or liability
of, the Company hereunder. 
  

 A-2Form of Executive Employment Agreement

 Exhibit 10.2 
 ISTA PHARMACEUTICALS, INC. 
 EXECUTIVE EMPLOYEE AGREEMENT 
 (Form for ISTA Vice Presidents) 
 This Executive Employee Agreement (“Agreement”) is entered into as of                      (the “Effective
Date”), by and between                      (“Executive”) and ISTA Pharmaceuticals, Inc., a Delaware corporation (the
“Company”). 
 WHEREAS, the Company desires to continue to employ Executive to provide personal services to the Company, and
wishes to provide Executive with certain compensation and benefits in return for these services; and 
 WHEREAS, Executive wishes to
continue to be employed by the Company and provide personal services to the Company in return for certain compensation and benefits, including the benefits provided under this Agreement; and 
 WHEREAS, Executive and the Company wish this Agreement to replace and supercede any other agreements or arrangements existing as of the Effective
Date between Executive and the Company providing for severance or other benefits upon termination of employment including but not limited to [insert applicable agreement(s)] (collectively, the “Prior Security Agreements”).

 NOW, THEREFORE, in consideration of the mutual promises and covenants contained herein, it is hereby agreed by and between the
parties hereto as follows: 
 1. EMPLOYMENT BY THE COMPANY. Subject to the terms and conditions set forth herein, the Company agrees
to employ Executive to render full time services as the Company’s [insert position title] and in such other capacities as the Company’s Chief Executive Officer (“CEO”) or Board of Directors (“Board”) may assign.
Executive hereby accepts employment based on the terms and conditions set forth herein effective as of the Effective Date. In this position, Executive shall perform such duties as are assigned by the CEO of the Company or such other officer of the
Company or one of its subsidiaries that the CEO in his discretion may from time to time designate (the “Designated Officer”) or as may be required by the Company’s Board. During Executive’s employment with the Company, Executive
will devote Executive’s best efforts and substantially all of Executive’s business time and attention to the business of the Company. Executive shall abide by the general employment policies and procedures of the Company, except that
wherever the terms of this Agreement may differ from or are in conflict with the Company’s general employment policies or procedures, this Agreement shall control. 
 2. COMPENSATION. 
 2.1 Salary. For services to be rendered hereunder,
Executive shall receive a base annual salary as set forth in Section 1 of the Compensation and Severance Terms Schedule, attached hereto as Exhibit A. Executive will be considered annually for adjustments in base salary. Any such
adjustments will be subject to review and approval by the CEO, Designated Officer, the Compensation Committee of the Board, and/or the Board, as appropriate. 
  

 1 

 2.2 Bonus. Executive shall be eligible to participate in the Company’s bonus
plan at the executive level. Notwithstanding the foregoing, no bonus is guaranteed to Executive. The Company shall have the sole discretion to determine whether Executive is entitled to any such bonus and to determine the amount of the bonus. Any
bonus is subject to the approval of the CEO, Designated Officer, the Compensation Committee of the Board, and/or the Board, as appropriate. To be eligible to receive any bonus, Executive must be employed by the Company throughout the entire fiscal
year or as otherwise set forth in the applicable bonus plan and be employed at the time the bonus is paid out. The current target level of such discretionary bonus for Executive is set forth in Section 2 of Exhibit A attached hereto. The
Company retains the authority to review, grant, deny or revise any bonus or target level in its sole discretion. 
 2.3
Equity Awards. Subject to approval of the Board or the Compensation Committee of the Board, as appropriate, Executive will be eligible to receive grants of stock options, restricted stock or other equity awards as may from time to time be
granted or awarded, pursuant to the terms and conditions set forth in the applicable equity award agreement and plan documents, copies of which will be made available upon Executive’s request. For the purposes of this Agreement, all stock
options, restricted stock or other equity awards granted to Executive by the Company hereunder, or granted in the future, shall be referred to hereinafter as the “Equity Awards.” 
 2.4 Vacation, Holiday Pay and Sick Leave. Executive shall be entitled to four (4) weeks of paid vacation each year. Any earned
but unused vacation shall be accrued and may be used by Executive in any subsequent year. Upon termination of Executive’s employment for any reason, Executive shall receive vacation pay for all earned but unused vacation, calculated at his base
salary rate in effect at the time of termination. The Company shall also provide Executive with holiday pay and paid sick leave as provided by the Company to its other executive employees of comparable stature. Any earned but unused sick leave shall
be accrued and may be used by Executive in any subsequent year; provided that, upon termination of Executive’s employment for any reason, Executive shall receive no pay or other compensation for any accrued but unused sick leave.
Notwithstanding the foregoing, vacation, holiday pay and sick leave do not accrue while Executive is on unpaid leave. 
 2.5 Standard Company Benefits. Executive shall receive all other employment benefits for which Executive is eligible under the terms and conditions of the standard Company benefits plans (e.g., health and disability insurance, 401(k)
retirement plan, etc.) and other benefits and incentives which may be in effect from time to time and provided by the Company to employees at levels similar to Executive. Employment benefits, including but not limited to vacation, holiday pay, sick
leave, paid insurance premiums, and other benefits do not accrue or continue during an unpaid leave, unless otherwise required by law. 
 3. PROPRIETARY INFORMATION AND INVENTIONS. 
 Executive shall comply with the terms of the Employee Proprietary
Information and Inventions Agreement, between the Company and Executive, in the form currently entered into and as amended from time to time, and/or such other agreement(s) between Executive and the Company protecting the confidential and
proprietary information and/or inventions of the Company as may be entered into after the date hereof (collectively, the “Employee Proprietary Information and Inventions Agreement”). The terms of the Employee Proprietary Information and
Inventions Agreement are incorporated herein by this reference. Notwithstanding any termination or expiration of this 

  

 2 

 
Agreement or termination of Executive’s employment, Executive agrees to continue to comply with the terms of the Employee Proprietary Information and
Inventions Agreement. 
 4. OUTSIDE ACTIVITIES. 
 4.1 Activities. Except with the prior written consent of the CEO, Executive will not during Executive’s employment with the
Company undertake or engage in any other employment, self-employment, occupation, consulting, or business enterprise, other than ones in which Executive is a passive investor. Without limiting the foregoing, Executive may not serve as a member of
the board of directors of any public or private for-profit company, except with the prior written consent of the CEO. Executive may engage in civic and not-for-profit activities so long as such activities do not materially interfere with the
performance of Executive’s duties hereunder. Executive will not during Executive’s employment with the Company or thereafter publicly or privately disparage the Company or any of its subsidiaries, or their respective past or present
products, officers, directors, employees, agents or customers. 
 4.2 Investments and Interests. During
Executive’s employment by the Company, Executive agrees not to acquire, assume or participate in, directly or indirectly, any position, investment or interest which is adverse to or in conflict with the interests of the Company, its current and
anticipated business or prospects, financial or otherwise. By way of clarification, nothing contained in this Agreement shall prevent Executive from holding, for investment purposes only, no more than one percent (1%) of the capital stock of
any publicly traded company. 
 4.3 Non-Competition. During Executive’s employment by the Company, except on
behalf of the Company, Executive will not directly or indirectly, whether as an officer, director, employee, stockholder, partner, proprietor, associate, representative, consultant, contractor, or in any other capacity whatsoever engage in, become
financially interested in, be employed by or have any business connection with any other person, corporation, firm, partnership or other entity whatsoever that competes with the Company, anywhere in the world, in any line of business engaged in (or
planned to be engaged in) by the Company. 
 5. OTHER AGREEMENTS. 
 Executive represents and warrants that Executive’s employment by the Company will not conflict with and will not be constrained by any prior
agreement or relationship with any third party. Executive represents and warrants that Executive will not disclose to the Company or use on behalf of the Company any trade secrets or other confidential information of any third party except in
accordance with an agreement between the Company and any such third party. During Executive’s employment by the Company, Executive may use, in the performance of Executive’s duties, all information generally known and used by persons with
training and experience comparable to Executive’s own and all information which is common knowledge in the industry or otherwise legally in the public domain. 
 6. TERMINATION OF EMPLOYMENT. 
 6.1 At Will Employment. Executive’s
relationship with the Company is at will. The Company shall have the right to terminate Executive’s employment with the Company at any time with or without Cause and with or without advance notice. 
  

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 6.2 Termination by Company for Cause. The Company may terminate Executive’s
employment for Cause at any time effective on written notice to Executive. In the event of a termination for Cause, the Company’s sole obligation and liability to Executive shall be to pay Executive any unpaid salary, together with any unused
vacation accrued to the effective date of such termination. Executive will not be entitled to severance benefits or any other compensation of any kind resulting from Executive’s termination for Cause. For purposes of this Agreement,
“Cause” shall mean any of the following events, as determined by the Company: (i) Executive’s conviction of any felony; (ii) Executive’s deliberate attempt to do injury to the Company; (iii) dishonest or fraudulent
conduct by Executive; (iv) Executive’s misconduct, gross negligence, material violation of Company policy, or material breach of this Agreement; or (v) Executive’s unsatisfactory performance of Executive’s duties to the
Company which, with respect to this clause (v), Executive fails to correct within thirty (30) days after Executive is given written notice by the CEO or the Board, as appropriate. 
 6.3 Termination by Company Without Cause. The Company shall be entitled at any time to terminate Executive’s employment
without Cause, effective upon written notice to Executive. If the Company terminates Executive’s employment at any time without Cause, Executive shall be entitled to those severance benefits specifically set forth in Section 3.1 of the
Compensation and Severance Terms Schedule, attached hereto as Exhibit A. 
 6.4 Executive’s Voluntary
Resignation. Executive may terminate Executive’s employment with the Company at any time. In the event Executive voluntarily terminates Executive’s employment other than for Good Reason involving a Change in Control Termination as
provided in Section 7, the Company’s sole obligation and liability to Executive shall be to pay Executive any unpaid salary, together with any accrued, unused vacation, through the effective day of resignation. Executive will not be
entitled to severance benefits or any other compensation of any kind resulting from Executive’s voluntary termination. 
 6.5 Termination for Death or Disability. Executive’s employment with the Company will be terminated in the event of Executive’s death, or any illness, injury, disability or other incapacity that renders Executive physically
or mentally unable to perform the essential duties of Executive’s job. The Company acknowledges its obligations under all leave of absence laws, including the California Family Rights Act and the federal Family and Medical Leave Act, and, to
the extent provided by these and other applicable laws, will provide reasonable accommodation for any known disability of an otherwise qualified employee, unless undue hardship would result. In the event that Executive’s employment with the
Company is terminated for death or disability as described in this Section 6.5, Executive or Executive’s heirs, successors, and assigns shall not receive any severance benefits or other compensation other than payment of accrued salary and
vacation and such other benefits as may be expressly required in such event by applicable law or the terms of applicable benefit plans. 
 6.6 Cessation of Severance Benefits. If Executive violates any provision of Sections 3 or 4 of this Agreement or the Employee Proprietary Information and Inventions Agreement, either during employment or
thereafter, then, notwithstanding anything herein to the contrary, the Company shall have the right upon written notice to Executive to immediately cease payment of any severance benefits being provided to Executive, and Executive will not be
entitled to any further compensation from the Company. 
  

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 7. CHANGE IN CONTROL. 
 7.1 Definitions. 
 (a) Definition of “Change in Control.” For purposes of this Agreement, “Change in Control” shall mean the occurrence of any of the following events: 
 (i) The acquisition, directly or indirectly, in one transaction or a series of related transactions, by any person or group (within the
meaning of Section 13(d)(3) or 14(d)(2) of the Exchange Act) of the beneficial ownership of securities of the Company possessing more than fifty percent (50%) of the total combined voting power of all outstanding securities of the Company;

 (ii) A merger or consolidation of the Company with any other entity, whether or not the Company is the surviving entity in
such transaction, except for a transaction in which the holders of the outstanding voting securities of the Company immediately prior to such merger or consolidation hold as a result of holding Company securities prior to such transaction, in the
aggregate, securities possessing more than fifty percent (50%) of the total combined voting power of all outstanding voting securities of the Company or of the surviving entity (or the parent of the surviving entity) immediately after such
merger or consolidation; 
 (iii) The sale, transfer or other disposition (in one transaction or a series of related
transactions) of all or substantially all of the assets of the Company; or 
 (iv) The approval by the stockholders of a plan
or proposal for the liquidation or dissolution of the Company. 
 (b) Definition of “Good Reason.” For
purposes of this Agreement, “Good Reason” shall mean any one of the following events which occurs on or after the Effective Date and after a Change in Control: (i) any material reduction of Executive’s then existing annual base
salary; (ii) any material reduction in the package of benefits and incentives, taken as a whole, provided to Executive (except that employee contributions may be raised to the extent of any cost increases imposed by third parties) or any action
by the Company which would materially and adversely affect Executive’s participation or reduce Executive’s benefits under any such plans, except to the extent that such benefits and incentives of all other executive officers of the Company
are similarly reduced; (iii) any material diminution of Executive’s duties and responsibilities, taken as a whole, excluding for this purpose an isolated, insubstantial or inadvertent action not taken in bad faith which is remedied by the
Company immediately after notice thereof is given by Executive; (iv) any material breach by the Company of its obligations under this Agreement; (v) any failure by the Company to obtain the assumption of this Agreement by any successor or
assign of the Company; or (vi) any requirement that Executive relocate to a work site that would increase Executive’s one-way commute distance by more than fifty (50) miles from Executive’s then principal residence, unless
Executive accepts such relocation opportunity. 
 7.2 Termination After a Change in Control. In the event
Executive’s employment with the Company is terminated without Cause, or Executive resigns for Good Reason, within twenty-four (24) months following a Change in Control (a “Change in Control Termination”), then Executive shall be
eligible for severance benefits as set forth in Section 3.2 of Exhibit A, attached hereto. Executive may resign Executive’s employment for Good Reason so long as 

  

 5 

 
Executive tenders his resignation to the Company within sixty (60) days after the occurrence of the event which forms the basis for Executive’s
termination for Good Reason. 
 7.3 Parachute Payments. In the event that the severance, acceleration of Equity Awards
and other benefits provided for in this Agreement (“Agreement Benefits”), together with benefits otherwise payable to Executive, (i) constitute a “parachute payment” within the meaning of Section 280G (as it may be
amended or replaced) of the Internal Revenue Code of 1986, as amended or replaced (the “Code”), and (ii) but for this Section 7.3, would be subject to the excise tax imposed by Section 4999 (as it may be amended or replaced)
of the Code (the “Excise Tax”), then Executive’s Agreement Benefits shall be either: 
 (a) provided to
Executive in full, or 
 (b) provided to Executive only as to such lesser extent that would result in no portion of
such Agreement Benefits being subject to the Excise Tax, 
 whichever of the foregoing amounts, taking into account the applicable federal, state and local
income taxes and the Excise Tax, results in the receipt by Executive, on an after-tax basis, of the greatest amount of benefits, notwithstanding that all or some portion of such Agreement Benefits may be taxable under the Excise Tax. 
 Unless the Company and Executive otherwise agree in writing, any determination required under this Section 7.3 shall be made in writing in good faith by the
Company’s independent registered accounting firm or such other nationally or regionally recognized accounting firm selected by the Company (the “Accountants”), whose determination shall be conclusive and binding upon Executive and the
Company for all purposes. In the event of a reduction in benefits hereunder, Executive shall be given the choice, subject to approval by the Company, of which benefits to reduce; provided that such reduction achieves the result specified in clause
(b) of this Section 7.3. For purposes of making the calculations required by this Section 7.3, the Accountants may make reasonable assumptions and approximations concerning applicable taxes and may rely on reasonable, good faith
interpretations concerning the application of the Code. The Company and Executive shall furnish to the Accountants such information and documents as the Accountants may reasonably request in order to make a determination under this Section 7.3.
The Company shall bear all costs the Accountants may reasonably incur in connection with any calculations contemplated by this Section 7.3. 
 8. RELEASE. In exchange for the severance benefits referenced in this Agreement and in Exhibit A attached hereto to which Executive would not otherwise be entitled, in the event of a termination without Cause or a Change in
Control Termination, Executive shall execute and enter into a release of claims against the Company in the form provided by the Company (the “Release”) upon Executive’s termination of employment. Unless the Release is executed by
Executive and delivered to the Company within the time limits specified in the Release, then notwithstanding anything herein to the contrary, Executive shall not receive any of the severance compensation or benefits provided under this Agreement;
acceleration, if any, of Executive’s Equity Awards as provided in this Agreement shall not apply; and Executive’s Equity Awards in such event may be exercised following the date of Executive’s termination only to the extent provided
under their original terms in accordance with the applicable equity plans and Equity Award agreements. 
  

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 9. GENERAL PROVISIONS. 
 9.1 Notices. Any notices provided hereunder must be in writing and shall be deemed effective upon personal delivery (including,
personal delivery by facsimile transmission) or the third day after mailing by first class mail, to the Company at its primary office location and to Executive at Executive’s address as listed on the Company payroll (which address may be
changed by written notice). 
 9.2 Severability. Whenever possible, each provision of this Agreement will be
interpreted in such manner as to be effective and valid under applicable law, but if any provision of this Agreement is held to be invalid or unenforceable in any respect under any applicable law or rule in any jurisdiction, such invalidity or
unenforceability will not affect any other provision or any other jurisdiction, and such invalid or unenforceable provision shall be reformed, construed and enforced in such jurisdiction so as to render it valid and enforceable consistent with the
intent of the parties insofar as possible. 
 9.3 Waiver. If either party should waive any breach of any provisions of
this Agreement, he or it shall not thereby be deemed to have waived any preceding or succeeding breach of the same or any other provision of this Agreement. 
 9.4 Counterparts. This Agreement may be executed in separate counterparts, any one of which need not contain signatures of more
than one party, but all of which taken together will constitute one and the same Agreement. 
 9.5 Headings. The
headings of the sections hereof are inserted for convenience only and shall not be deemed to constitute a part hereof nor to affect the meaning thereof. 
 9.6 Successors and Assigns. This Agreement is intended to bind and inure to the benefit of and be enforceable by Executive, the Company and their respective successors, assigns, heirs, executors and
administrators, except that Executive may not assign any of Executive’s duties or rights hereunder, without the written consent of the Company. 
 9.7 Arbitration. To provide a mechanism for rapid and economical dispute resolution, Executive and the Company agree that any and all disputes, claims, or causes of action, in law or equity, arising from or
relating to Executive’s employment, compensation, this Agreement (including the Release upon which the payment of severance benefits is conditioned) or the enforcement, performance, breach, or interpretation of this Agreement, will be resolved
by final and binding arbitration held in Orange County, California and conducted by Judicial Arbitration & Mediation Services/Endispute (“JAMS”), under its then-existing Rules and Procedures. Executive understands that final and
binding arbitration will be the sole and exclusive remedy for any such claim or dispute between him and the Company and its parent, subsidiary or affiliated companies or entities, and each of its and/or their employees, officers, directors or
agents, and that, by agreeing to use arbitration to resolve such claims or disputes, both the Company and Executive agree to forego any right each may have had to a jury trial. Both Executive and the Company will have the right to conduct reasonable
discovery in such arbitration proceeding as determined by the arbitrator and as provided by the procedural rules applicable to arbitration proceedings referenced above. In addition, both Executive and the Company will have the right to assert
counterclaims and to bring motions otherwise available in civil actions, including for example, demurrers, motions for summary judgment, motions for judgment, etc. Notwithstanding the foregoing, nothing in this Section 9.7 or 

  

 7 

 
in this Agreement shall prevent either Executive or the Company from seeking and obtaining injunctive relief in any court to prevent irreparable harm from
any breach or threatened breach of the provisions of Sections 3 or 4 of this Agreement or the Employee Proprietary Information and Inventions Agreement pending resolution of any arbitration hereunder. The provisions of this Section 9.7 shall
survive the termination or expiration of this Agreement and termination of Executive’s employment and shall remain in full force and effect thereafter. 
 9.8 Remedies. Executive’s duties under Sections 3 and 4 of this Agreement and the Employee Proprietary Information and
Inventions Agreement shall survive termination or expiration of this Agreement and termination of Executive’s employment with the Company. Executive acknowledges that a remedy at law for any breach or threatened breach by Executive of the
provisions of these Sections and the Employee Proprietary Information and Inventions Agreement would be inadequate, and that such a breach would cause irreparable harm to the Company; and Executive therefore agrees that the Company shall be entitled
to injunctive relief in case of any such breach or threatened breach. 
 9.9 Governing Law. All questions concerning
the construction, validity and interpretation of this Agreement will be governed by the law of the State of California as applied to contracts made and to be performed entirely within California. 
 10. TERM OF AGREEMENT. This Agreement shall become effective as of the Effective Date and shall remain in effect through the period ending on the
third anniversary of the Effective Date (the “Initial Term”) and shall automatically renew for successive one (1) year periods (the “Extended Term) unless the Company, in its sole discretion with or without reason, provides
written notice to Executive of non-renewal (a “Non-renewal Notice”) no later than sixty (60) days before the expiration date of the Initial Term or any Extended Term, in which case this Agreement shall expire upon on such expiration
date. As used herein, the “Term” shall mean the Initial Term and any Extended Term. Notwithstanding the foregoing, in the event a Change in Control occurs during the Term then the Term of this Agreement shall continue and may not be
terminated until the expiration of twenty-four (24) months after the Change in Control unless consented to in writing by Executive and the Company. Expiration or termination of the Term of this Agreement shall not relieve the parties of any
obligation accruing prior to such expiration or termination, including but not limited to any obligation of the Company to pay the severance and other benefits to Executive hereunder for any termination without Cause or a Change in Control
Termination which occurs prior to the expiration or termination of the Term of this Agreement. By way of clarification, a Non-renewal Notice shall not constitute a notice of termination of Executive’s employment and termination or expiration of
the Term of this Agreement shall not constitute termination of Executive’s employment resulting in any obligation of the Company to provide the severance benefits hereunder. The Company has no obligation to pay severance benefits to Executive
hereunder arising from any termination of Executive’s employment after the expiration or termination of the Term of this Agreement. The provisions of Sections 3, 4, 9, 10 and 11 of this Agreement shall survive the expiration or termination of
the Term of this Agreement. 
 11. ENTIRE AGREEMENT. This Agreement, together Exhibit A attached hereto, the Employee
Proprietary Information and Inventions Agreement, the Company’s Employee Handbook and Policies, as amended from time to time, and the applicable equity plans and Equity Award agreements, constitute the final, complete, and exclusive embodiment
of the entire agreement between Executive and the Company regarding the subject matter hereof and supersede any prior agreement, promise, representation, or statement, written or otherwise, between Executive and the 

  

 8 

 
Company with regard to this subject matter including but not limited to the Prior Security Agreements. Without limiting the foregoing, the parties hereby
terminate each and all Prior Security Agreements and Executive hereby releases and forever waives any rights Executive may have against the Company under any Prior Security Agreement. This Agreement is entered into without reliance on any promise,
representation, statement or agreement other than those expressly contained or incorporated herein, and it cannot be modified or amended except in a writing signed by Executive and a duly authorized officer of the Company. 
 12. RESIGNATION OF OTHER COMPANY POSITIONS. In the event of any termination of Executive’s employment with the Company, unless otherwise
agreed to in writing by Executive and the Board, Executive shall be deemed to have resigned as of the date of such termination as an officer and/or director of the Company and any of its subsidiaries or affiliated companies for which Executive was
serving in such capacities at the time of such termination. At the Company’s request, Executive agrees to execute concerning one or more such positions so held resignation letter(s) in the form provided by the Company evidencing the foregoing.

 IN WITNESS WHEREOF, the parties have executed this Agreement effective as of the Effective Date above written. 
  

			
	 ISTA PHARMACEUTICALS, INC.

		
	 By:
	 	  
		
	 Its:
	 	  
	
	 EXECUTIVE

		
	  	 	  

  

 9 

 EXHIBIT A 
 COMPENSATION AND SEVERANCE TERMS SCHEDULE 
 1. BASE SALARY 
 For services to be rendered under this Agreement, Executive shall receive an annual gross base salary of
($            ), payable in accordance with the Company’s standard payroll practices, and subject to adjustment as set forth in the Agreement. 
 2. BONUS 
 Executive’s annual
bonus, if granted, shall be at a target level of up to             % of Executive’s then current base salary. 
 3. SEVERANCE BENEFITS 
 3.1 Termination by Company Without Cause. If the Company terminates Executive’s employment at any time without Cause as defined in Section 6.3 of the Agreement, the Company shall provide the following severance compensation
and benefits to Executive after the effective date of the Release referenced in Section 8 of the Agreement: 
 (a) A
severance payment equal to the sum of nine (9) months of Executive’s then current base salary, payable (subject to Section 4 below of this Exhibit A) by the Company in a lump sum, less legally required withholdings, within
thirty (30) days after the effective date of the Release referenced in Section 8 of the Agreement; 
 (b) Health
insurance premiums payable by the Company for continued health insurance coverage for Executive and all then currently insured dependents for up to nine (9) months after the termination date of Executive’s employment, provided that
Executive makes a timely election to continue such coverage under COBRA; and provided further that, the Company’s obligation to pay the monthly health insurance premiums for continued group medical insurance shall end when Executive becomes
eligible for health insurance with a new employer, and Executive agrees to promptly notify the Company in writing of any such event of eligibility; and 
 (c) Outplacement services for one year, at the Company’s expense up to a maximum amount of twenty-five thousand dollars ($25,000), with a nationally recognized service selected by the Company. 
 Executive understands that Executive’s receipt of the severance compensation and benefits specified in this Section 3.1 is conditioned upon Executive’s
execution of the Release referenced in Section 8 of the Agreement, and further understands that the above lists the only severance compensation and benefits to which Executive is entitled. 
  

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 3.2 Change in Control Termination. In the event of a Change in Control Termination
as defined in Section 7.2 of the Agreement, the Company shall provide the following severance compensation and benefits to Executive after the effective date of the Release referenced in Section 8 of the Agreement: 
 (a) A severance payment equal to the sum of (i) twelve (12) months of Executive’s then current base salary and
(ii) one (1) times Executive’s target bonus to be earned for the year in which termination occurs or one (1) times the bonus amount paid to Executive in the prior year, whichever is greater, payable (subject to Section 4
below of this Exhibit A) by the Company in a lump sum, less legally required withholdings, within thirty (30) days after the effective date of the Release referenced in Section 8 of the Agreement; and, 
 (b) Health insurance premiums payable by the Company for continued health insurance coverage for Executive and all then currently insured
dependents for up to twelve (12) months after the termination date of Executive’s employment, provided that Executive makes a timely election to continue such coverage under COBRA; and provided further that, the Company’s obligation
to pay the monthly health insurance premiums for continued group medical insurance shall end when Executive becomes eligible for health insurance with a new employer, and Executive agrees to promptly notify the Company in writing of any such event
of eligibility; and 
 (c) Outplacement services for one year, at the Company’s expense up to a maximum amount of
twenty-five thousand dollars ($25,000), with a nationally recognized service selected by the Company; and 
 (d) Any unvested
and outstanding Equity Awards held by Executive shall become one hundred percent (100%) vested as of the termination date of Executive’s employment. In this regard, without limiting the foregoing, but by way of clarification, all stock
options granted by the Company to Executive shall become fully vested and exercisable as of the termination date of Executive’s employment to the extent such stock options are outstanding and unexercisable at the time of such termination and
all stock subject to a right of repurchase by the Company (or its successor) that was purchased by Executive shall have such right of repurchase lapse with respect to all of the shares at the time of such termination. To the extent necessary to
effect the intent of this Agreement with respect to the Equity Awards, the applicable provisions of the Agreement and this Exhibit A shall be deemed an amendment to each agreement evidencing an Equity Award held by Executive. 
 Executive understands that Executive’s receipt of the severance compensation and benefits specified in this Section 3.2 is conditioned upon Executive’s
execution of the Release referenced in Section 8 of the Agreement, and further understands that the above lists the only severance compensation and benefits to which Executive is entitled. 
 4. SECTION 409A: DEFERRED COMPENSATION PLANS 
 4.1 Key Employee. Notwithstanding any other provision of the Agreement and this Exhibit A, as determined in the sole discretion of the Company, if Executive is a “Key Employee” within the
meaning of Section 416(i)(1) of the Code in the calendar year of Executive’s termination of employment with the Company, then the severance payment under Section 3.1(a) or Section 3.2(a), as applicable, shall be payable no sooner
than one hundred and eighty-three (183) calendar days following the effective date of Executive’s termination. 
 4.2 Section 409A Compliance. The intent of Executive and the Company is that the severance and other benefits payable to Executive under this Agreement not be deemed “deferred compensation” under Section 409A of
the Code. Executive and the Company agree to use reasonable best efforts to amend the terms of this Agreement from time to time as may be necessary to avoid the material imposition of penalties and additional taxes under Section 409A(a)(1) of
the Code; provided however, any such amendment will provide Executive substantially equivalent economic payments and benefits as set forth herein and will not in the aggregate, materially increase the cost to, or liability of, the Company hereunder.

  

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