Document:

<Page>
                                                                   Exhibit 10.16

                            FIRST AMENDMENT TO LEASE

     This First Amendment to Lease (this "AMENDMENT") is made and entered into
as of the ____ day of November, 2003 by and between ONE OAK PARK DRIVE, L.L.C.,
a Delaware limited liability company (the "LANDLORD") having an address at c/o
Connelly Properties, L.L.C., 57 Bedford Street, Suite 100, Lexington,
Massachusetts 02420, and CAMBRIDGE HEART, INC., a Delaware corporation (the
"TENANT") having an address at One Oak Park Drive, Bedford, Massachusetts
01730.

                                WITNESSETH THAT:

     WHEREAS, pursuant to a Lease Agreement dated June __, 2000 (the "LEASE"),
the Landlord leased to the Tenant certain space in that certain building known
as and numbered One Oak Park Drive, in the Town of Bedford, Middlesex County,
Massachusetts, as more particularly described in the Lease;

     WHEREAS, the Landlord and the Tenant wish to amend the Lease in certain
respects;

     NOW THEREFORE, in consideration of the foregoing recitals and for further
good and valuable consideration, the receipt and adequacy of which are hereby
acknowledged, the Landlord and the Tenant do hereby agree as follows:

1.   EFFECTIVE DATE; DEFINITIONS. For purposes of this Amendment, the "EFFECTIVE
DATE" shall mean December 1, 2003. The amendments to the Lease set forth in
Section 2 of this Amendment shall be effective prospectively only, commencing on
the Effective Date. Such amendment shall have no retroactive effect with respect
to periods occurring prior to the Effective Date. Unless the context requires
otherwise, the terms used herein shall be construed in conformity with the
definitions set forth in the Lease.

2.   AMENDMENTS TO LEASE. Effective as of the Effective Date, the Lease is
amended as follows:

     a.   Paragraph 1 of the Lease is amended by substituting "10,480" for
"11,000" where it appears in the Paragraph.

     b.   Paragraph 3 of the Lease is amended by substituting "at midnight on
November 30, 2005" for "at midnight on the last day of the month in which the
third (3rd) anniversary of the Term Commencement Date occurs" where it appears
in such Paragraph.

     c.   Paragraph 5 of the Lease is amended by deleting the Paragraph in its
entirety and substituting the following in place thereof.

<Page>

     "5.  BASIC RENT

          Commencing on the Term Commencement Date, and continuing through and
     including November 30, 2003, the Tenant shall pay Basic Rent to the
     Landlord at the annual rate of One Hundred Thirty-Two Thousand and 00/100
     Dollars ($132,000.00), payable in advance on the first day of each calendar
     month in equal installments at the rate of Eleven Thousand and 00/100
     Dollars ($11,000.00) per month. Commencing on December 1, 2003, and
     continuing through and including November 30, 2005, the Tenant shall pay
     Basic Rent to the Landlord at the annual rate of One Hundred Twenty
     Thousand Five Hundred Twenty and 00/100 Dollars ($120,520.00), payable in
     advance on the first day of each calendar month in equal installments at
     the rate of Ten Thousand Forty-Three and 34/100 Dollars ($10,043.34) per
     month. Basic Rent shall be payable to the Landlord at the address set forth
     above or such other address as the Landlord may thereafter specify by
     notice to the Tenant, without counterclaim, set off, deduction or defense
     and, except as otherwise expressly provided herein, without abatement."

     d. Paragraph 6 of the Lease is amended by deleting the Paragraph in its
entirety and substituting the following in place thereof:

     "6.  OPERATING EXPENSES; TAXES

          a.   DEFINITIONS. As used herein, the following terms shall have the
     following respective meanings:

               i.   "BASE OPERATING EXPENSES": The aggregate amount of Operating
          Expenses incurred by the Landlord during calendar year 2004.

               ii.  "BASE TAXES": The aggregate amount of Taxes incurred by the
          Landlord during calendar year 2004.

               iii. "OPERATING EXPENSES": Collectively, any and all charges,
          costs and expenses of every kind and nature whatsoever that the
          Landlord may from time to time actually incur, and the reasonable
          value, based on competitive rates, of any materials and services that
          the Landlord may provide in good faith with respect to the ownership,
          operation and maintenance of the Building and the Property, including,
          without limitation, (1) making repairs to and undertaking maintenance
          of the Building and the Property, including all alterations and
          improvements to the common areas of the Building; (2) providing
          utilities, including heat, water, sewer, electricity, air conditioning
          and ventilation to the Premises and to the common areas of the
          Building and the Property (expressly excluding electricity service for
          the Premises, for which the Tenant shall pay a separate charge as
          provided in Paragraph 8); (3) providing daily cleaning and rubbish
          removal; (4) providing watering, landscaping and lawn care for the
          Property; (5) sanding, plowing and removal of snow and ice from
          driveways, walkways and parking areas; (6) maintaining casualty and
          liability insurance with respect to the Landlord, the Premises, the
          Building and the Property;

                                       2
<Page>

          (7)  reasonable administrative and management costs of the Landlord,
          but "Operating Expenses" shall not include any of the expenses set
          forth in EXHIBIT B attached hereto.

               IV.  "TAXES": Any and all real estate taxes, betterments and
          special assessments or amounts in lieu or in the nature thereof and
          any other taxes, levies, water rents, sewer use charges and other
          excises, franchises, imposts and charges, general and special (and the
          entire amount of any interest, penalties and costs attributable to
          delayed payment of the Tenant's portion thereof where such delay is
          the fault of the Tenant) of whatever name and nature, and whether or
          not now within the contemplation of the parties hereto, which may now
          or hereafter be levied, assessed or imposed by the United States of
          America, The Commonwealth of Massachusetts, the Town of Bedford or any
          other authority, or become a lien upon all or any part of the
          Property, the Building, the Premises, the use or occupation thereof,
          or upon the Landlord and the Tenant in respect thereof, or upon the
          basis of rentals thereof or therefrom, or upon the estate hereby
          created, or upon the Landlord by reason of ownership of the reversion.
          Notwithstanding the foregoing, "Taxes" shall not include exclude (i)
          franchise, corporate, estate, gift, inheritance, succession, capital
          levy, transfer tax, and income or profits taxes or charges upon the
          rent payable by Tenant under the Lease, (ii) any fines, interest,
          penalties and the like imposed as the result of late payment (unless
          such late payment was caused by the Tenant's late payment of its share
          of the excess), and (iii) any amounts resulting from improvements made
          to the Building or the Property by the Landlord or any other person
          other than the Tenant after the Building and the Property were
          assessed for purposes of calculating Base Taxes.

               v.   "TENANT'S PERCENTAGE": Fifty Percent (50%).

          b.   ADJUSTMENT OF OPERATING EXPENSES. If during any portion of any
     calendar year (including calendar year 2004 for purposes of establishing
     Base Operating Expenses), at least 95% of the Building's rentable area was
     not occupied by tenants, then actual Operating Expenses incurred by the
     Landlord shall be reasonably extrapolated by the Landlord to the estimated
     Operating Expenses that would have been incurred if the Building were fully
     occupied by tenants and, for purposes of this Paragraph 6, 95% of such
     extrapolated amount shall be deemed to be the Operating Expenses for such
     year.

          c.   TENANT'S PAYMENT OF OPERATING EXPENSE AND TAX EXCESS. The Tenant
     shall pay to the Landlord, as Additional Rent, the Tenant's Percentage of
     the amount, if any, by which the aggregate of Operating Expenses and Taxes
     in any calendar year shall exceed the aggregate of Base Operating Expenses
     and Base Taxes. The Tenant shall prepay to the Landlord monthly, in the
     same manner as Basic Rent, one-twelfth (1/12) of the total of all such
     amounts that the Landlord may from time to time reasonably estimate will be
     payable, by the Tenant under this Paragraph 6(c) in respect of such
     excess. As soon as any such amounts so payable are actually determined,
     appropriate adjustments of any overpayments or underpayments shall be made
     by the Landlord and the Tenant.

                                       3
<Page>

          d.   TENANT'S PAYMENT OF OTHER TAXES. The Tenant shall pay or cause to
     be paid to the Landlord as Additional Rent not later than ten (10) days
     prior to the date the same are due or twenty-one (2l) days after written
     notice thereof to the Tenant, whichever is later, all taxes and excises
     upon the personal property and equipment of the Tenant located at the
     Premises or the Property.

          e.   OTHER ADDITIONAL RENT. The Tenant agrees to pay, in addition to
     the Tenant's obligations with respect to taxes, insurance premiums,
     utilities costs, costs of repairs and maintenance and other costs which are
     specifically set forth herein, to the Landlord upon demand as Additional
     Rent: (i) any and all charges, costs, expenses, and obligations of every
     kind and nature whatsoever as the Landlord may from time to time actually
     incur in good faith with regard to the Premises or the operation or
     maintenance thereof, except as otherwise expressly agreed in this Lease,
     including, without limiting the generality of the foregoing, reasonable
     attorneys' fees incurred by the Landlord in connection with any amendments
     to, consents under and subleases and assignments of this Lease requested by
     the Tenant and in connection with the enforcement of rights and pursuit of
     the remedies of the Landlord under this Lease (whether during or after the
     expiration or termination of the Term of this Lease), and (ii) all other
     costs identified in this Lease as "ADDITIONAL RENT."

          f.   LATE PAYMENTS. If any payment of Basic Rent or Additional Rent is
     not paid to the Landlord when due or within any applicable grace period,
     then at the Landlord's option, without notice and in addition to all other
     remedies hereunder, the Tenant shall pay upon demand to the Landlord, as
     Additional Rent, interest thereon at an annual rate equal to the corporate
     rate of Fleet Bank (or its successor) from time to time in effect, plus
     four percent (4%), such interest to be computed from the date such Basic
     Rent or Additional Rent was originally due through the date when paid in
     full.

          g.   REAL ESTATE TAX ABATEMENTS. Subject to the rights of any
     Mortgagees (as hereinafter defined), the Landlord may, at the request of
     the Tenant or any other tenant or tenants of the Building, use reasonable
     efforts to obtain an abatement of or to contest or review by legal
     proceedings or otherwise any such tax, levy, charge or assessment. In such
     event the Tenant and such other tenants shall pay such tax, levy, charge or
     assessment (under protest, if necessary). The Tenant shall pay as
     Additional Rent the Tenant's Percentage of (i) any such tax, levy, charge
     or assessment that may be determined to be due, and (ii) any and all costs
     or expenses (including reasonable attorneys' fees) that the Landlord may
     incur in connection with any such proceedings. The Tenant shall be entitled
     to share in any refund or abatement, net of such costs and expenses, which
     may be made of any tax, levy, charge or assessment in the same proportion
     that the same was paid by the Tenant or with the Tenant's funds."

          e.   The Lease is amended to add a new Paragraph 33 to read in its
     entirety as follows:

               "33. EXTENSION OF THE TERM

                                       4
<Page>

          On the conditions (any one or more of which conditions the Landlord
     may waive, at its election, by written notice to the Tenant at any time)
     that (i) both at the time of option exercise and as of the commencement of
     the applicable extension term, the Tenant is not in default of its
     covenants and obligations under this Lease beyond all applicable grace and
     cure periods, (ii) the Landlord has not given the Tenant two (2) or more
     notices of default within any consecutive twelve (12) month period during
     the Term, and (iii) as of the commencement of the applicable extension
     term, Cambridge Heart, Inc. occupies the entire Premises, the Tenant may
     elect to extend the Term as follows:

          a.   The Tenant may elect to extend the Term for a one (1) year period
     commencing December 1, 2005, but only if the Tenant gives notice thereof to
     the Landlord by June 1, 2005, but not before December 1, 2004. If the
     Tenant so elects to extend the Term, such extension shall be on the same
     terms and conditions set forth herein, except Basic Rent, which shall be
     determined as hereinafter set forth.

          b.   The word "Term" as used elsewhere in this Lease shall, unless
     otherwise expressly provided herein, include the initial Term and such one
     (1) year extension period, if the Tenant shall have given timely and proper
     notice of exercise of its option to so extend the Term. Time shall be of
     the essence for any notice permitted or required to be given hereunder.

          c.   The annual rate of Basic Rent payable during the one (1) year
     extension period of the Term shall be payable without offset at an annual
     rate equal to the greater of (i) the effective annual rate of Basic Rent
     payable during the year immediately prior to the commencement of such
     extension period, and (ii) the "Market Rent" determined as hereinafter
     provided. The "MARKET RENT" shall be the fair rental value for space of
     equivalent size and character in Bedford, Massachusetts under a one year
     lease, taking into account all relevant factors.

          d.   The Market Rent shall be proposed by the Landlord within thirty
     (30) days of the receipt of the Tenant's notice that it intends to extend
     the term of the Lease. The Market Rent so proposed by the Landlord is
     referred to herein as the "LANDLORD'S PROPOSED MARKET RENT." The Landlord's
     Proposed Market Rent shall he deemed to be the Market Rent unless the
     Tenant notifies the Landlord, within fifteen (15) days of the Tenant's
     receipt of the Landlord's Proposed Market Rent notice, that the Landlord's
     Proposed Market Rent is not satisfactory to the Tenant (the "TENANT'S
     REJECTION NOTICE").

          e.   If the Market Rent is not otherwise agreed upon by the Landlord
     and the Tenant within fifteen (15) days after the Landlord's receipt of the
     Tenant's Rejection Notice, then:

               (1)  The Landlord and the Tenant shall notify one another within
          ten (10) days of the expiration of said fifteen day period of the
          name and address of the appraiser designated by each. Such two (2)
          appraisers shall, within twenty (20) days after the designation of the
          second appraiser, make their determination of the Market

                                       5
<Page>

          Rent in writing and give notice thereof to each other and to the
          Landlord and the Tenant. Such two (2) appraisers shall have twenty
          (20) days after the receipt of notice of each other's determinations
          to confer with each other and to attempt to reach agreement as to the
          determination of the Market Rent. If such appraisers shall concur in
          such determination within said twenty (20) day period, then they shall
          give notice thereof to the Landlord and the Tenant and such
          concurrence shall be final and binding upon the Landlord and the
          Tenant. If such appraisers shall fail to concur as to such
          determination within said twenty (20) day period, then they shall give
          notice thereof to the Landlord and the Tenant and shall immediately
          designate a third appraiser. If the two (2) appraisers shall fail to
          agree upon the designation of such third appraiser within five (5)
          days after said twenty (20) day period, then they or either of them
          shall give notice of such failure to agree to the Landlord and the
          Tenant and, if the Landlord and the Tenant fail to agree upon the
          selection of such third appraiser within five (5) days after the
          appraiser(s) appointed by the parties give notice as aforesaid, then
          either party on behalf of both may apply to the American Arbitration
          Association or any successor thereof to designate a third appraiser,
          or on such association's failure, refusal or inability to act, to a
          court of competent jurisdiction, for the designation of such third
          appraiser.

               (2)  All appraisers shall be commercial real estate brokers who
          shall have had at least ten (10) years' continuous experience as a
          commercial real estate broker in the Boston, Massachusetts area.

               (3)  The third appraiser shall conduct such investigations as he
          or she may deem appropriate and shall, within ten (10) days after the
          date of his or her designation, make an independent determination of
          the Market Rent.

               (4)  If none of the determinations of the appraisers varies from
          the mean of the determinations of the other appraisers by more than
          ten percent (10%), the mean of the determinations of the three (3)
          appraisers shall be the Market Rent of the Premises. If, on the other
          hand, the determination of any single appraiser varies from the mean
          of the determinations of the other two (2) appraisers by more than ten
          percent (10%), the mean of the determination of the two (2) appraisers
          whose determinations are closest shall be the Market Rent.

               (5)  The determination of the appraisers, as provided above,
          shall be conclusive upon the parties and shall have the same force and
          effect as a judgment made in a court of competent jurisdiction.

               (6)  Each party shall pay fees, costs and expenses of the
          appraiser selected by it and its own counsel fees and one-half (1/2)
          of all other expenses and fees of any such appraisal."

3.   CONFIRMATION OF TENANT'S OBLIGATION TO PAY FOR UTILITIES. The Tenant
confirms and agrees that, pursuant to Paragraph 8 of the Lease, the Tenant is
obligated to pay, directly to the appropriate

                                        6
<Page>

utility company, all charges relating to the provision of electricity to the
Premises during the Term (including, without limitation, electricity to power
heat and air conditioning for the Premises), as measured by separate meters
serving the Premises. The Tenant also confirm and agrees that, pursuant to
Paragraph 8 of the Lease, the Tenant is obligated to pay for: water beyond
normal office usage, telephone service, overtime and special services as set
forth in Paragraph 8 of the Lease, and any additional HVAC facilities used in
connection with any room devoted substantially to the operation of one or more
computers, which amounts the Landlord shall reasonably determine. All such
amounts payable by the Tenant under Paragraph 8 of the Lease shall constitute
Additional Rent under the Lease.

4.   LANDLORD'S WORK. The Landlord shall, at its sole cost and expense, perform
the work described in EXHIBIT A attached hereto. The Landlord shall exercise
diligent and commercially reasonable efforts to complete this work by December
15, 2003.

5.   BROKERS. The Landlord and the Tenant each warrant and represent to the
other that it has not dealt with any broker or finder with respect to this
Amendment other than The Staubach Company of New England, LLC and Meredith &
Grew (collectively, the "RECOGNIZED BROKERS"). The Landlord shall be responsible
for paying each of the Recognized Brokers a brokerage commission pursuant to a
separate agreement between the Landlord and such Recognized Broker. The Landlord
and the Tenant shall each defend, indemnify and hold the other harmless from and
against any and all liability, claims, suits, demands, judgments, costs,
interest and expense (including, without being limited to, reasonable attorneys'
fees and expenses) which the indemnified party may be subject to or suffer by
reason of any claim made by any person, firm or corporation, other than either
of the Recognized Brokers, for any commission, expense or other compensation as
a result of the execution and delivery of this Amendment, which is based on
alleged conversations or negotiations by said person, firm or corporation with
the indemnifying party and in breach of the foregoing representations.

6.   MISCELLANEOUS. This Amendment may be executed in several counterparts, each
of which will be deemed an original, and all of such counterparts together shall
constitute one and the same instrument. Except as hereby modified, the Lease is
ratified and confirmed and remains in full force and effect.

                    [Signatures Appear on the Following Page]

                                       7
<Page>

     IN WITNESS WHEREOF, the Landlord and the Tenant have caused this
instrument to be executed under seal as of the day and year first above
written.

                                  LANDLORD:

                                  ONE OAK PARK DRIVE, L.L.C., a Delaware
                                  limited liability Company

                                  By:   Connelly Properties, L.L.C., a Delaware
                                        limited liability company, its
                                        Authorized Person

                                        By:____________________________________
                                             Name:   Mark W. Connelly
                                             Title:  Manager

                                  TENANT:

                                  CAMBRIDGE HEART, INC., a Delaware
                                  corporation

                                  By: /s/ David Chazanovitz
                                      _________________________________
                                        Name:   David Chazanovitz
                                        Title:  Pres & CEO

<Page>

                                   EXHIBIT A

                                Landlord's Work

ENVIRONMENT

     a.   Add a plastic curtain to the exterior shipping door.

     b.   Add small heater hanging from ceiling to heat the shipping area.

     c.   All necessary caulking will be done.

     d.   Door and frame in shipping area will be replaced and painted.

     e.   Replace three (3) VAV 17kw heating and cooling boxes, replace
eighteen (18) control damper motors for all existing HVAC boxes and eighteen
(18) new digital thermostats. We will put back the electronic time clock that
Cambridge Heart asked us to remove so that the setback will work properly.
Replace the flex duct with hard duct and add diffuser deflectors with fire
rings where needed. Rebalance the entire system.

     f.   We will provided Cambridge Heart with a plan showing the zone for
each thermostat.

MAINTENANCE & REPAIRS

     a.   Bathroom countertops will be replaced.

     b.   Metal dividers will be replaced.

     c.   Shipping area ceiling tile will be replaced.

     d.   Broken and scarred ceiling tiles will be replaced throughout the
building.

     e.   Vinyl baseboard in the shipping area will be replaced.

     f.   Security light will have dusk to dawn.

     g.   Pest Control will be addressed.

DEMO

     a.   Partitioning next to Bob P's office will be removed.

     b.   Approximately 10 linear feet of partitioning between the service
area and manufacturing area will be removed.

<Page>

     c.   Approximately 26 linear feet of partitioning will be removed next
to the service area.

     d.   Approximately 13 linear feet of partitioning will be removed by the
stock room.

CONSTRUCTION

     a.   Build approximately 50 linear feet of drywall partitioning per
drawing dated 8/11/03.

     b.   Replace carpet throughout the entire premises with Landlord's
standard carpet, color and type to be selected by the Tenant.

     c.   Paint the entire premises the same color as it is now.

     d.   Electric will be modified as needed to accommodate the demo & new
construction.

     e.   Provide vertical blinds for the front reception area.

     f.   Provide and install a 6070 solid cote birch finish door with hollow
metal frame (Dutch type door).

     g.   Loading dock pad will be increased to 20 feet long by 11 feet wide.

     h.   In Cambridge Heart's CEO office we will take existing wallboard
down, insulate, and then replace wallboard with 5/8 inch wallboard extending
above the ceiling. We will also replace insulation above the office ceiling.

                              [End of Exhibit A]
<Page>

                                  EXHIBIT B
                      Exclusions from Operating Expenses

      Operating Expenses, as defined in Paragraph 6(a)(iii) of the Lease,
shall not include any of the following:

      (i)     interest, principal, points and fees, amortization or other
      costs associated with any debt and rent payable under any lease to which
      this Lease is subject, and all costs and expenses associated with any
      such debt or lease and any ground lease rent, irrespective of whether
      this Lease is subject or subordinate thereto;

      (ii)    expenses reimburseable to the Landlord by other tenants or
      third parties for services provided directly to such parties, to the
      extent such services are either not provided to the Tenant, or are
      provided in excess of the services provided to the Tenant;

      (iii)   costs reimbursed to the Landlord from the proceeds of insurance
      or condemnation awards;

      (iv)    expenses incurred by the Landlord to resolve disputes, or
      enforce or negotiate lease terms, with prospective or existing tenants,
      or in connection with the negotiation of the terms of any financing,
      sale or syndication of the Building;

      (v)     costs of alterations, capital improvements, equipment replacement
      and other items that are, under GAAP, properly classified as capital
      expenditures, PROVIDED, HOWEVER, that the Landlord may include in the
      Common Expenses, on an annual basis, the amount of principal and interest
      payments that would be required to pay for each capital item over its
      useful life (as determined by the Landlord in accordance with GAAP as
      in effect at the time of acquisition of the capital item), with level
      payments of principal and interest, at an annual interest rate of six
      percent (6%);

      (vi)    expenses incurred by the Landlord to lease space to new tenants
      or to retain existing tenants, including leasing commissions, advertising
      and promotional expenditures;

      (vii)   expenses incurred by the Landlord to prepare, renovate, repaint,
      redecorate or perform any other work in any space leased to an existing
      tenant or prospective tenant of the Building;

      (viii)  costs of repairs or replacements necessary due to damage caused
      by the Landlord or the Landlord's agents, employees or contractors, or by
      other tenants in the Building;

      (ix)    any penalty or fine incurred by the Landlord due to the
      Landlord's violation of any federal, state, or local law or regulation;

      (x)     property management fees in excess of 2.5% of the Building's
      gross rents each year; and,

<Page>

      (xi)    costs associated with the operation of the business of the
      partnership or entity that constitutes the Landlord, as the same are
      distinguished from the costs of operation of the Building and the
      Property, including partnership accounting and legal matters, costs of
      defending any lawsuits with any mortgagee (except as the actions of the
      Tenant may be in issue), costs of selling, syndicating, financing,
      mortgaging, or hypothecating any of the Landlord's interests in the
      Building, costs of any disputes between the Landlord and employees
      (if any) not engaged in Building operation, disputes of the Landlord
      with Building management, or outside fees paid in connection with
      disputes with other tenants.

                             [End of Exhibit B]<PAGE>

                                                                 Exhibit 10.28

          Confidential Materials omitted and filed separately with the
         Securities and Exchange Commission. Asterisks denote omissions.

               AMENDMENT #5 TO CONSULTING AND TECHNOLOGY AGREEMENT

                             RICHARD JONATHAN COHEN

                                       And

                              CAMBRIDGE HEART, INC.

The Consulting and Technology Agreement ("Agreement") originally dated February
8, 1993 and amended May 26, 1998, June 1, 2000, January 1, 2002 and January 1,
2003 is amended effective May 7, 2003.

1)       The term of the CONSULTING PERIOD is extended to May 31, 2015.
         Effective January 1, 2004 COHEN's obligation in terms of consulting
         time is reduced to 18 days per year.

2)       The royalties on NET SALES due COHEN under Paragraph 6.1 of the
         Agreement are hereby adjusted as follows:

         i)       In calendar year 2003, the royalty for each fiscal quarter
                  shall be one percent (1%) on all NET SALES up to the amount of
                  NET SALES achieved in the corresponding quarter in the
                  previous year, and one and one-half percent (1.5%) on all NET
                  SALES in excess of the amount of NET SALES achieved in the
                  corresponding quarter in the previous year. If NET SALES for
                  calendar year 2003 shall be greater than or equal to $[**] but
                  less than $[**] then the company shall pay COHEN by February
                  28, 2004 an additional amount to bring the total royalty paid
                  on NET SALES for calendar year 2003 up to one and four tenths
                  percent (1.4%) of NET SALES for calendar year 2003. If the NET
                  SALES for calendar year 2003 shall be greater than or equal to
                  $[**] then the company shall pay COHEN by February 28, 2004 an
                  additional amount to bring the total royalty paid on NET SALES
                  for calendar year 2003 up to one and five tenths percent
                  (1.5%) of NET SALES for calendar year 2003.

         ii)      In calendar year 2004, the royalty for each fiscal quarter
                  shall be one percent (1%) on all NET SALES up to the amount of
                  NET SALES achieved in the corresponding quarter in the
                  previous year, and one and one-half percent (1.5%) on all NET
                  SALES in excess of the amount of NET SALES achieved in the
                  corresponding quarter in the previous year. If the NET SALES
                  for calendar year 2004 shall be greater than or equal to $[**]
                  but less than $[**] then the company shall pay COHEN by
                  February 28, 2005 an additional amount to bring the total
                  royalty paid on NET SALES for calendar year 2004 up to one and
                  four tenths percent (1.4%) of NET SALES for

<PAGE>

                  calendar year 2004. If the NET SALES for calendar year 2004
                  shall be greater than or equal to $[**] then the company shall
                  pay COHEN by February 28, 2005 an additional amount to bring
                  the total royalty paid on NET SALES for calendar year 2004 up
                  to one and five tenths percent (1.5%) of NET SALES for
                  calendar year 2004.

         iii)     Effective January 1, 2005 and continuing through May 31, 2015
                  the royalty on NET SALES shall be increased to one and five
                  tenths percent (1.5%) of NET SALES.

3)       COHEN is hereby granted options to purchase 300,000 shares of common
         stock of Cambridge Heart, Inc at a price of $0.34 per share. These
         options shall remain in force for ten years from the effective date of
         this agreement, shall vest immediately, and not be contingent on COHEN
         having an ongoing consulting or employment relationship with the
         company. This grant however shall be contingent on the company's
         stockholders approving by June 30, 2003 all motions or resolutions
         necessary to allow this grant.

4)       The monthly retainer for consulting services is reduced to zero
         effective July 1, 2003. However, if the company's shareholders shall
         fail to approve by June 30, 2003 all motions or resolutions necessary
         to allow both the restricted stock grant issued under Amendment #4 to
         this Agreement and the stock options issued under this Amendment #5,
         the monthly retainer for consulting services shall revert to $15,000
         per month effective July 1, 2003.

5)       Further extension of the term of the CONSULTING PERIOD shall be
         contingent upon written agreement of the parties.

6)       Section 2.4 (including subsections (a), (b), and (c)) of the Agreement
         - which relates to the option of the Company to hire COHEN, should he
         leave his current MIT employment, on a full time basis at a multiple of
         his annual consulting fee - is hereby annulled.

Terms not otherwise defined herein shall have the meanings assigned to them in
the Agreement.

All of the other terms of the Agreement are hereby ratified and confirmed.

RICHARD J. COHEN                             CAMBRIDGE HEART, INC

By: /s/ RICHARD J. COHEN                     By: /s/ DAVID CHAZANOVITZ
    --------------------                         ---------------------

                                       2

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00064-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00064-of-00352.parquet"}]]