Document:

FOURTH AMENDMENT

            FOURTH AMENDMENT (this "Fourth Amendment"), dated as of February 8,
2000, to the Credit Agreement, dated as of March 4, 1997, as modified by the
Waiver and First Amendment dated as of November 25, 1997, the Waiver dated as of
February 11, 1998, the Waiver and Second Amendment dated as of May 27, 1998, the
Waiver dated as of November 13, 1998 and the Third Amendment dated as of October
8, 1999 (as the same may be further amended, supplemented or otherwise modified
from time to time, the "Credit Agreement"), among PACKARD BIOSCIENCE COMPANY, a
Delaware corporation ("Packard"), the Subsidiary Borrowers party thereto, the
lenders from time to time parties thereto (the "Lenders"), BANC OF AMERICA
SECURITIES LLC and CIBC OPPENHEIMER CORP., as co-arrangers and co-syndication
agents (in such capacities, the "Co-Arrangers" and the "Co-Syndication Agents"),
CANADIAN IMPERIAL BANK OF COMMERCE, as documentation agent (in such capacity,
the "Documentation Agent"), and BANK OF AMERICA, N.A., as administrative agent.

                              W I T N E S S E T H :

            WHEREAS, Packard has requested that the Lenders agree to amend the
Credit Agreement upon the terms and subject to the conditions set forth herein;
and

            WHEREAS, the Lenders have agreed to such amendment only upon the
terms and subject to the conditions set forth herein;

            NOW, THEREFORE, in consideration of the premises and the mutual
covenants contained herein, the parties hereto hereby agree as follows:

            1. Defined Terms. Capitalized terms not otherwise defined herein
have the meanings ascribed to such terms in the Credit Agreement.

            2. Amendments to Section 1.1. (a) The definition of "Applicable
Margin" set forth in Section 1.1 of the Credit Agreement is hereby amended and
restated in its entirety as follows:

            "Applicable Margin": (a) in the case of Revolving Credit Loans, the
      per annum rate determined pursuant to the Pricing Grid, (b) in the case of
      Term Loans that are Base Rate Loans, 2-1/4% per annum, and (c) in the case
      of Term Loans that are Eurodollar Loans, 3-1/4% per annum.

            (b) Section 1.1 of the Credit Agreement is hereby amended by adding
the following new definition in the appropriate alphabetical order:

            "CCP Earn-Out Payments": payments made by Packard or any of its
      Subsidiaries in connection with the acquisition by Packard or any of its
      Subsidiaries of the portion of the Capital Stock of Carl Consumable
      Products LLC ("CCP") not already owned by it in an amount not to exceed
      25% of the amount by which operating profit of CCP (determined in
      accordance with the documentation entered into in connection with such
      acquisition as originally in effect) exceeds $530,000, for each of the
      fiscal years from 2000 through 2004.

            3. Amendment to Section 5.7(d). The percentage "3-3/4%" set forth in
Section 5.7(d) of the Credit Agreement is hereby changed to "4-1/4%".

<PAGE>

                                                                               2

            4. Amendment to Section 8.2(c). Section 8.2(c) of the Credit
Agreement is hereby amended by adding the following parenthetical immediately
after the words "45 days after the end of each fiscal year of Packard" contained
therein:

      "(or, in the case of Projections for the 2000 fiscal year, no later than
      April 15, 2000)"

            5. Amendments to Section 9.8(g). (a) Section 9.8(g) of the Credit
Agreement is hereby amended by (a) changing the amount "$70,000,000" to the
amount "$85,000,000".

            (b) Section 9.8(g) of the Credit Agreement is hereby amended by
adding the following sentence to the end thereof.

      "In addition to the foregoing, the CCP Earn-Out Payments shall be
      permitted, and shall not count as utilization of any of the basket amounts
      set forth in this paragraph."

            6. Pricing Grid. The Pricing Grid is hereby amended and restated in
its entirety as follows:

<TABLE>
<CAPTION>
===============================================================================================================
 Consolidated Leverage Ratio         Applicable Margin          Applicable Margin for       Commitment Fee Rate
                                    for Eurodollar Loans           Base Rate Loans
---------------------------------------------------------------------------------------------------------------
<S>                                        <C>                          <C>                        <C>
Greater than or equal to
4.50:1.00                                  2.875%                       1.875%                     0.500%
---------------------------------------------------------------------------------------------------------------
Greater than or equal to
4.00:1.00, but less than
4.50:1.00                                  2.250%                       1.250%                     0.375%
---------------------------------------------------------------------------------------------------------------
Greater than or equal to
2.50:1.00, but less than 4.00              1.750%                       0.750%                     0.300%
---------------------------------------------------------------------------------------------------------------
Less than 2.50:1.00                        1.250%                       0.250%                     0.250%
===============================================================================================================
</TABLE>

            7. Conditions to Effectiveness. This Fourth Amendment shall become
effective (the actual date of such effectiveness, the "Fourth Amendment
Effective Date") as of the date first above written when (a) counterparts hereof
shall have been duly executed and delivered by the Required Lenders, Packard and
the Administrative Agent and acknowledged by each Subsidiary Guarantor and (b)
Packard shall have paid to the Administrative Agent for distribution to the
relevant Lenders an amendment fee (the "Amendment Fee") equal to 0.125% of the
sum of the Revolving Credit Commitment and Term Loans of each Lender that has
submitted an executed signature page to this Amendment by facsimile transmission
to the Administrative Agent or its counsel prior to 12:00 Noon, California time,
on February 15, 2000.

            8. Representations. Packard represents and warrants that:

            (a) this Fourth Amendment has been duly authorized, executed and
      delivered by Packard;

            (b) each of this Fourth Amendment, and the Credit Agreement as
      amended by this Fourth Amendment, constitutes the legal, valid and binding
      obligation of Packard;

<PAGE>

                                                                               3

            (c) each of the representations and warranties set forth in Section
      6 of the Credit Agreement are true and correct as of the Fourth Amendment
      Effective Date; provided that references in the Credit Agreement to this
      "Agreement" shall be deemed references to the Credit Agreement as amended
      by this Fourth Amendment; and

            (d) after giving effect to this Fourth Amendment, there does not
      exist any Default or Event of Default.

            9. Continuing Effect. Except as expressly amended or waived hereby,
the Credit Agreement shall continue to be and shall remain in full force and
effect in accordance with its terms.

            10. Expenses. Packard agrees to pay and reimburse the Administrative
Agent for all of its out-of-pocket costs and expenses incurred in connection
with the negotiation, preparation, execution, and delivery of this Fourth
Amendment, including the reasonable fees and expenses of counsel to the
Administrative Agent.

            11. Counterparts. This Fourth Amendment may be executed on any
number of separate counterparts and all of said counterparts taken together
shall be deemed to constitute one and the same instrument.

            12. GOVERNING LAW. THIS FOURTH AMENDMENT SHALL BE GOVERNED BY, AND
CONSTRUED AND INTERPRETED IN ACCORDANCE WITH, THE LAW OF THE STATE OF NEW YORK.

            IN WITNESS WHEREOF, the parties hereto have caused this Fourth
Amendment to be duly executed and delivered by their proper and duly authorized
officers as of the day and year first above written.

                                       PACKARD BIOSCIENCE COMPANY

                                       By:______________________________________
                                          Name:
                                          Title:

                                       CANBERRA SEMICONDUCTOR N.V.

                                       By:______________________________________
                                          Name:
                                          Title:

<PAGE>

                                                                               4

                                       HARWELL INSTRUMENTS LIMITED

                                       By:______________________________________
                                          Name:
                                          Title:

                                       BANK OF AMERICA, N.A., as Administrative
                                       Agent

                                       By:______________________________________
                                          Name:  Dietmar Schiel
                                          Title: Vice President

                                       BANK OF AMERICA, N.A., as a Lender

                                       By:______________________________________
                                          Name:
                                          Title:

                                       CANADIAN IMPERIAL BANK OF COMMERCE

                                       By:______________________________________
                                          Name:
                                          Title:

                                       ABN AMRO BANK N.V.

                                       By:______________________________________
                                          Name:
                                          Title:

                                       By:______________________________________
                                          Name:
                                          Title:

BANKBOSTON, N.A.                       FLEET NATIONAL BANK

By:___________________________         By: ______________________________
Name:                                  Name:
Title:                                 Title:

<PAGE>

                                       BANK OF SCOTLAND

                                       By:______________________________________
                                          Name:
                                          Title:

                                       IBJ WHITEHALL BANK & TRUST COMPANY
                                         (fka IBJ Schroder Bank & Trust Company)

                                       By:______________________________________
                                          Name:
                                          Title:

                                       GENERAL ELECTRIC CAPITAL CORPORATION

                                       By:______________________________________
                                          Name:
                                          Title:

                                       CITIZENS BANK OF MASSACHUSETTS
                                         (successor to State Street Bank and
                                         Trust Company)

                                       By:______________________________________
                                          Name:
                                          Title:

                                       ALLSTATE LIFE INSURANCE COMPANY

                                       By:______________________________________
                                          Name:
                                          Title:

                                       By:______________________________________
                                          Name:
                                          Title:

<PAGE>

                                       ALLSTATE INSURANCE COMPANY

                                            By:_________________________________
                                               Name:
                                               Title:

                                            By:_________________________________
                                               Name:
                                               Title:

                                       THE NORTHWESTERN MUTUAL LIFE INSURANCE
                                       COMPANY

                                       By:______________________________________
                                          Name:
                                          Title:

                                       SENIOR DEBT PORTFOLIO

                                       By:  Boston Management and Research,
                                            as Investment Advisor

                                            By:_________________________________
                                               Name:
                                               Title:

                                       COMMERCIAL LOAN FUNDING TRUST I

                                       By:  Lehman Commercial Paper, Inc.,
                                            not in its individual capacity but
                                            solely as Administrative Agent

                                            By:_________________________________
                                               Name:
                                               Title:

                                       FEDERAL STREET PARTNERS

                                       By:______________________________________
                                          Name:
                                          Title:

<PAGE>

                                       EATON VANCE SENIOR INCOME TRUST

                                       By:  Eaton Vance Management, as
                                            Investment Advisor

                                            By:_________________________________
                                               Name:
                                               Title:

                                       CITIZENS BANK OF CONNECTICUT

                                            By:_________________________________
                                               Name:
                                               Title:

                                            By:_________________________________
                                               Name:
                                               Title:Amendment No. 2 to Stockholders' Agreement

      Amendment No. 2, dated as of January 23, 1998, to the Stockholders'
Agreement, dated as of March 4, 1997 (the "Stockholders' Agreement"), by and
among Packard BioScience Company, a Delaware corporation ("Packard"), the
Management Stockholders listed in Schedule 1 thereto, the Non-Management
Stockholders listed in Schedule 2 thereto, Merrill Lynch KECALP L.P. 1994,
KECALP Inc. and Stonington Capital Appreciation 1994 Fund, L.P.

      WHEREAS, pursuant to, and in accordance with, Section 6.4 of the
Stockholders' Agreement, the parties hereto wish to amend the Stockholders'
Agreement on the terms contained herein.

      NOW THEREFORE, the parties hereto agree as follows:

      1. Amendments. The Stockholders' Agreement is hereby amended as follows:

            (a) Definitions.

                  (i) The definition of the term "Institutional Investors" set
forth in the preamble to the Agreement is hereby amended by adding Merrill Lynch
KECALP L.P. 1997 thereto.

      2. Governing Law. This Amendment shall be governed by and construed in
accordance with the internal laws of the State of Delaware without reference to
the application of principles of conflicts law.

      3. Reaffirmation. In all respect not inconsistent with the terms and
provisions of this Agreement No. 2, the Stockholders' Agreement shall continue
to be in full force and effect in accordance with the terms and conditions
thereof, and is hereby ratified, adopted, approved and confirmed. From and after
the date hereof, each reference to the Stockholders' Agreement in any other
instrument or document shall be deemed a reference to the Stockholders'
Agreement as amended hereby, unless the context otherwise requires.

      4. Waiver. None of the execution, delivery or performance of this
Amendment No. 2 shall operate as waiver of any condition, power, remedy or right
exercisable in accordance with the Stockholders' Agreement, or constitute a
waiver of any provision of the Stockholders' Agreement, except as expressly
provided herein.

<PAGE>

                                      -2-

      IN WITNESS WHEREOF, each of the parties hereto has duly executed this
Amendment No. 2, or has caused this Amendment No. 2 to be duly executed, as of
the date first above written.

                                    PACKARD BIOSCIENCE COMPANY

                                    By: /s/ Ben D. Kaplan
                                        ----------------------------------------
                                        Name:  Ben D. Kaplan
                                        Title: Vice President and Chief
                                               Financial Officer

                                    STONINGTON CAPITAL APPRECIATION
                                        1994 FUND, L.P.

                                    By: Stonington Partners, L.P.,
                                          its general partner

                                    By: Stonington Partners, Inc. II,
                                          its general partner

                                    By: /s/ Judith A. Witterschein
                                        ----------------------------------------
                                        Name:  Judith A. Witterschein
                                        Title: Vice President & Secretary

                                            /s/ Emery G. Olcott
                                    --------------------------------------------
                                                Emery G. Olcott

                                          /s/ Richard T. McKernan
                                    --------------------------------------------
                                              Richard T. McKernan

                                              /s/ George Serrano
                                    --------------------------------------------
                                                  George Serrano

                                              /s/ Orren Tench
                                    --------------------------------------------
                                                  Orren Tench

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