Document:

Seventh Amendment dated February 6, 2006, to Lease Agreement dated June 26, 1998

 Exhibit 10.251 
 SEVENTH LEASE AMENDMENT TO LEASE AGREEMENT 
 THIS SEVENTH LEASE AMENDMENT TO LEASE AGREEMENT (hereinafter referred to as the “Seventh Amendment”) is made as of the 6th day of February 2006, by and between DUKE REALTY LIMITED PARTNERSHIP, an Indiana limited
partnership doing business in North Carolina as Duke Realty of Indiana Limited Partnership, successor by merger to Weeks Realty, L.P. (hereinafter referred to as “Landlord”) and PPD DEVELOPMENT LP, a Texas limited partnership
and successor in interest to PPD Development, Inc. (hereinafter referred to as “Tenant”). 
 WITNESSETH: 
 WHEREAS, pursuant to a Lease Agreement dated June 26, 1998 by and between Landlord and Tenant, as amended by that certain First Lease Amendment to
Lease Agreement dated October 28, 1998, and as amended by that certain Second Amendment to Lease Agreement dated October 1, 2002, and as amended by that certain Third Lease Amendment to Lease Agreement dated September 22, 2003, and as
amended by that certain Fourth Lease Amendment to Lease Agreement dated March 31, 2005, and as amended by that certain Fifth Lease Amendment to Lease Agreement dated July 7, 2005, and as further amended by that certain Sixth Lease
Amendment to Lease Agreement dated December 30, 2005 (the Lease Agreement, and all amendments thereto shall be referred to herein collectively as the “Lease”), Landlord leased to Tenant certain premises consisting of approximately
96,145 rentable square feet (the “Premises”) in a building located on certain land (the “Land”) which had been provided the address of 4023 Paramount Parkway, but is now known as 3900 South Paramount Parkway, Morrisville, Wake
County, North Carolina 27560, all as more particularly described in the Lease; and 
 WHEREAS, the parties hereto desire to modify the Lease
to reflect a termination option; and 
 NOW, THEREFORE, for and in consideration of Ten Dollars ($10.00) paid by Landlord and Tenant to one
another, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged by Landlord and Tenant, Landlord and Tenant amend the Agreement as follows: 
 1. Surrender of a Portion of the Premises. Pursuant to Section 17.03(b) of that certain Office Lease by and between Landlord and Tenant dated
December 29, 2005 for the lease of approximately 30,000 rentable square feet of space in a building to be constructed by Landlord at 3800 Paramount Parkway, Morrisville, North Carolina 27560 (the “3800 Lease”), Tenant has the option
to surrender one or more of Suites 150, 225 and 250 (each a “Suite”) of the Premises if at anytime prior to the third anniversary of the execution of the 3800 Lease, the rentable square footage of the premises under the 3800 Lease is
increased to 60,000 rentable square feet pursuant to the terms of Section 17.03(b) of the 3800 Lease. (Tenant acknowledging, however, that while Tenant shall have the right to surrender less than all three of said Suites, Tenant shall not have
the right to surrender only a portion of a Suite). In order to exercise said surrender right, Tenant shall notify Landlord of such exercise within ten (10) days following Tenant’s execution and delivery of an amendment to the 3800 Lease
evidencing the expansion of the premises under the 3800 Lease, and together with such notice Tenant shall deliver to Landlord an amount equal to all accrued and unpaid interest together with the unamortized portion of any tenant improvement
allowance attributable to such Suite(s) that are being surrendered under the Lease. In the event Tenant exercises this surrender right, Landlord and Tenant shall enter into an amendment to the Lease whereby with respect to such Suite(s) under the
Lease. Landlord and Tenant shall be released and discharged from their respective obligations under the Lease with respect to such Suite(s), and neither party shall have any further liability under the Lease with respect to such Suite(s), excluding,
however, the obligations of Tenant attributable to any period of the Lease on or prior to the Surrender Date (including without limitation the payment of Minimum Annual Rent and the Annual Rental Adjustment) and any obligations of Tenant under the
Lease which survive termination thereof. The effective date of the surrender of such Suite(s) (the “Surrender Date”) shall be the commencement date of the lease of such expansion space under the 3800 Lease. 
 2. Severability. In the event any term, covenant or condition of this Amendment, the Lease, or any amendments thereto shall to any extent be
invalid or unenforceable, the remainder shall not be affected thereby and each term, covenant or condition shall be valid and enforceable to the full extent permitted by law. 
 3. Successors and Assigns. This Amendment shall apply to, inure to the benefit of, and be binding upon the parties hereto and upon their
respective heirs, legal representatives, successors and permitted assigns, except as otherwise provided herein. 

 4. Authority of Tenant. Tenant certifies to Landlord that it is authorized to enter into this
Amendment, and that those persons signing below on its behalf are authorized to do so, and shall promptly upon the request of Landlord provide a resolution to this effect. 
 5. Interpretation. Although the printed provisions of this Amendment were drafted by Landlord, such fact shall not cause this Amendment to be
construed either for or against Landlord or Tenant. All capitalized terms, not otherwise defined, shall be defined as provided in the Lease. 
 6. Full Force and Effect. Except as modified hereby, the Lease remains unmodified and in full force and effect. 
 7.
Governing Law. This Amendment shall be governed by and construed in accordance with the laws of the State of North Carolina. 
 8.
Mutual Acknowledgment of Non-Existence of Claims. Landlord and Tenant acknowledge and agree that as of the day hereof there are no known claims by either party against the other party hereto arising from the relationship as Landlord and
Tenant, respectively, pursuant to the Lease, as amended. 
 9. Confidentiality. Except as otherwise required by law to be disclosed by
Tenant, the terms and provisions of the Lease and this Amendment are strictly confidential, are to be shared by Tenant only with its accountant, employees, and attorneys, and each of those parties shall be advised of the confidential nature of the
lease and this Amendment. 
 [Execution signatures contained on the following page] 

 IN WITNESS WHEREOF, the undersigned have caused this Amendment to be executed under seal and delivered as
of the day and year first above written. 
  

													
		 		 	 LANDLORD:

			
		 		 	 DUKE REALTY LIMITED PARTNERSHIP, an
 Indiana limited partnership doing business in North
 Carolina as Duke Realty of Indiana Limited Partnership

					
		 		 		 	By:	 	 Duke Realty Corporation, an
 Indiana corporation, its
General
 Partner

					
		 		 		 	By:	 	 /s/ H. Andrew Kelton

		 		 		 	Name:	 	H. Andrew Kelton
		 		 		 	Title:	 	Senior Vice President
				
		 		 		 	                            TENANT:

			
	 ATTEST:
	 		 	PPD DEVELOPMENT LP, a Texas limited partnership
							
		 	 By:
	 	 /s/ Charles H. Munn, Jr.
	 		 		 		 	
		 	 Name:
	 	Charles H. Munn, Jr.	 		 	By: PPD GP, LLC, a Delaware limited
		 	 Title
	 	Assistant General Counsel	 		 	liability company, its General Partner
							
		 		 		 		 		 	By:	 	 /s/ Fred B. Davenport, Jr.

		 		 		 		 		 	Name:	 	Fred B. Davenport, Jr.
		 		 		 		 		 	Title:	 	President
		 		 		 		 		 		 	
	Guarantor hereby executes this Amendment to evidence its consent to this Amendment.
					
		 		 		 		 	GUARANTOR:
			
	ATTEST:	 		 	 PHARMACEUTICAL PRODUCT
 DEVELOPMENT, INC., a North Carolina
 Corporation

		 	 By:
	 	 /s/ Charles H. Munn, Jr.
	 		 		 		 	
		 	 Name:
	 	Charles H. Munn, Jr.	 		 		 		 	
		 	 Title:
	 	Assistant General Counsel	 		 		 		 	
		 		 		 		 	By:	 	 /s/ Fred B. Davenport, Jr.

		 		 		 		 	Name:	 	Fred B. Davenport, Jr.
		 		 		 		 	Title:	 	President

 END OF EXECUTION SIGNATURESEighth Amendment dated September 24, 2007, to Lease Agreement

 Exhibit 10.252 
 EIGHTH LEASE AMENDMENT TO LEASE AGREEMENT 
 THIS EIGHTH LEASE AMENDMENT TO LEASE AGREEMENT (hereinafter referred to as the “Amendment”) is made as of the 24th day of September 2007, by and between DUKE REALTY LIMITED PARTNERSHIP, an Indiana limited
partnership doing business in North Carolina as Duke Realty of Indiana Limited Partnership, successor by merger to Weeks Realty, L.P. (hereinafter referred to as “Landlord”) and PPD DEVELOPMENT LP, a Texas limited partnership and
successor in interest to PPD Development, Inc. (hereinafter referred to as “Tenant”). 
 WITNESSETH: 
 WHEREAS, pursuant to a Lease Agreement dated June 26, 1998 by and between Landlord and Tenant, as amended by that certain First Amendment to Lease
Agreement dated October 28, 1998, and as amended by that certain Second Lease Amendment to Lease Agreement dated October 1, 2002, and as amended by that certain Third Lease Amendment to Lease Agreement dated September 22, 2003, and as
amended by that certain Fourth Lease Amendment to Lease Agreement dated March 31, 2005, and as amended by that certain Fifth Lease Amendment to Lease Agreement dated July 7, 2005, and as amended by that certain Sixth Lease Amendment to
Lease Agreement dated December 30, 2005, and as amended by that certain Seventh Lease Amendment to Lease Agreement dated February 6, 2006 (the Lease Agreement, and all amendments thereto shall be referred to herein collectively as the
“Lease”), Landlord leased to Tenant certain premises consisting of approximately 96,145 rentable square feet (the “Original Premises”) in a building located on certain land (the “Land”) which had been provided the
address of 4023 Paramount Parkway, but is now known as 3900 South Paramount Parkway, Morrisville, Wake County, North Carolina 27560, all as more particularly described in the Lease; and 
 WHEREAS, Landlord and Tenant desire to expand the Original Premises by approximately 9,427 rentable square feet labeled “Additional Space” on
Amended Exhibit A (“Additional Space”); and 
 WHEREAS, Landlord and Tenant desire to amend certain provisions of the
Lease to reflect such expansion and any other changes to the Lease; 
 NOW, THEREFORE, in consideration of the foregoing premises, the mutual
covenants herein contained and each act performed hereunder by the parties, Landlord and Tenant hereby enter into this Amendment. 
 1.
Incorporation of Recitals and Definitions. The above recitals are hereby incorporated into this Amendment as if fully set forth herein. All capitalized terms used herein but undefined shall have the meaning as defined in the Lease.

 2. Amendment of Article 1. Premises and Term. Commencing November 9, 2007, (the “Effective Date”) the
following paragraphs of Article 1 of the Lease are hereby amended as follows: 
 (a) Premises. As of the Effective Date, subparagraph
(a) of Article 1 of the Lease is hereby amended to provide that Tenant shall lease the Original Premises and the Additional Space which together shall consist of 105,572 rentable square feet of space and which space shall hereinafter
collectively be referred to as the “Premises”. 
 (b) Term. Subparagraph (b) of Article 1 of the Lease is hereby
modified to reflect that the term of the Additional Space shall commence on the Effective Date, and shall expire on November 8, 2013 (the “Expansion Term”) which shall be coterminous with the existing Lease Term. 
 3. Base Rent, Operating Expenses and Security Deposit.  
 (a) Original Premises. Base Rent, Additional Rent and operating expenses for the Original Premises shall continue to be due and payable as provided in the Lease. Base Rent for the Original Premises shall
continue to be subject to increases as provided in the Lease through November 8, 2013. Tenant’s proportionate share of Taxes (as defined in Article 2(b) of the Lease, hereinafter “Taxes”) and Operating Expenses for the Original
Premises shall continue to be due and payable as provided in the Lease. 
 (b) Base Rent. As of the Effective Date, paragraph 2(a) of
the Lease is amended by adding the following: 
 “Additional Space. Tenant shall pay to Landlord the Base Rent for the Additional
Space as follows: 
  

			
		 	Monthly
	 11/09/2007 – 03/08/2008
	 	$0.00(1)
	 03/09/2008 – 11/08/2008
	 	$15,507.42 (2)
	 11/09/2008 – 11/08/2013
	 	Adjusted as set forth below

  

	 (1)
	 represents four (4) months 

	 (2)
	 represents eight (8) months 

 On November 9, 2008 (the “Rent Adjustment Date”), Tenant’s Base Rent for the
Additional Space shall be adjusted to the lesser of (i) an amount equal to one hundred three percent (103%) of the Base Rent per square foot for the twelve (12) month period immediately preceding the Rent Adjustment Date, or
(ii) the then current Market Rent (as defined in the Lease) and taking into account the readjustment of the operating expenses as set out in Paragraph 2(b)(ii) of the Lease, as amended; provided, however, that in no event shall the Base Rent
per square foot, as adjusted, be less than Tenant’s then current rent. Beginning on November 9, 2009, Tenant’s Base Rent, as determined above, will be increased by three percent (3%) for each successive twelve (12) month
period through the expiration of the current Lease term.” 
 4. As of the Effective Date, Paragraph 2(b) of the Lease is amended by
adding the following: 
 “Operating Expenses. Tenant’s proportionate share of Taxes and Operating Expenses for the Additional
Space shall be 7.9% and shall be calculated in accordance with paragraph 2(b)(ii) of the Lease.” 
 5. Additional Space. Tenant
has personally inspected the Additional Space and accepts the same “AS IS” without representation or warranty by Landlord of any kind and without any obligation on the part of Landlord to construct any tenant improvements. 
 6. Severability. In the event any term, covenant or condition of this Amendment, the Lease, or any amendments thereto shall to any extent be
invalid or unenforceable, the remainder shall not be affected thereby and each term, covenant or condition shall be valid and enforceable to the full extent permitted by law. 
 7. Successors and Assigns. This Amendment shall apply to, inure to the benefit of, and be binding upon the parties hereto and upon their
respective heirs, legal representatives, successors and permitted assigns, except as otherwise provided herein. 
 8. Authority of
Tenant. Tenant certifies to Landlord that it is authorized to enter into this Amendment, and that those persons signing below on its behalf are authorized to do so, and shall promptly upon the request of Landlord provide a resolution to this
effect. 
 9. Interpretation. Although the printed provisions of this Amendment were drafted by Landlord, such fact shall not cause
this Amendment to be construed either for or against Landlord or Tenant. All capitalized terms, not otherwise defined, shall be defined as provided in the Lease. 
 10. Full Force and Effect. Except as modified hereby, the Lease remains unmodified and in full force and effect. 
 11. Governing Law. This Amendment shall be governed by and construed in accordance with the laws of the State of North Carolina. 
 12. Mutual Acknowledgment of Non-Existence of Claims. Landlord and Tenant acknowledge and agree that as of the day hereof there are no known claims by either party against the other party hereto arising from
the relationship as Landlord and Tenant, respectively, pursuant to the Lease, as amended. 
 13. Confidentiality. Except as otherwise
required by law to be disclosed by Tenant, the terms and provisions of the Lease and this Amendment are strictly confidential, are to be shared by Tenant only with its accountant, employees, and attorneys, and each of those parties shall be advised
of the confidential nature of the lease and this Amendment. 

 IN WITNESS WHEREOF, the parties have caused this Amendment to be executed on the day and year first
written above. 
  
  

													
		 		 	 LANDLORD:

			
		 		 	 DUKE REALTY LIMITED PARTNERSHIP, an
 Indiana limited partnership doing business in North
 Carolina as Duke Realty of Indiana Limited Partnership

				
		 		 	By:	 	 Duke Realty Corporation, an
 Indiana
Corporation, its general partner

					
		 		 		 	By:	 	 /s/ Jeffrey B. Sheehan

		 		 		 		 	Jeffrey B. Sheehan
		 		 		 		 	Senior Vice President, Raleigh Operations
			
		 		 	TENANT:
			
	 :
	 		 	PPD DEVELOPMENT LP, a Texas limited partnership
							
		 	 :
	 		 		 		 		 	
		 		 		 		 	By: PPD GP, LLC, a Delaware limited liability
		 		 		 		 		 	company, its General Partner
						
		 		 		 		 	By:	 	 /s/ William J. Sharbaugh

		 		 		 		 	Printed:	 	William J. Sharbaugh
		 		 		 		 	Title:	 	Chief Operating Officer
		 		 		 		 		 		 	
	Guarantor hereby executes this Amendment to evidence its consent to Tenant’s leasing of the Additional Space and to ratify that the Guaranty shall apply to the Additional Space
as well as to the Original Premises.
			
	WITNESS:	 		 	GUARANTOR:
			
		 		 	 PHARMACEUTICAL PRODUCT
 DEVELOPMENT, INC., a
North Carolina
 corporation

		 		 		 		 		 		 	
		 		 		 		 		 		 	
		 		 		 		 		 		 	
	  
	 		 	By:	 	 /s/ William J. Sharbaugh

	Print Name:	 	  
	 		 	Name:	 	William J. Sharbaugh
		 		 		 		 	Title:	 	Chief Operating Officer

 END OF EXECUTION SIGNATURES

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