Document:

Form of Note

 EXHIBIT 10.7 
 FORM OF NOTE 
 THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS
AMENDED, OR APPLICABLE STATE SECURITIES LAWS. THE SECURITIES MAY NOT BE OFFERED FOR SALE, SOLD, TRANSFERRED OR ASSIGNED (I) IN THE ABSENCE OF (A) AN EFFECTIVE REGISTRATION STATEMENT FOR THE SECURITIES UNDER THE SECURITIES ACT OF 1933, AS
AMENDED, OR APPLICABLE STATE SECURITIES LAWS OR (B) AN OPINION OF COUNSEL, IN A GENERALLY ACCEPTABLE FORM, THAT REGISTRATION IS NOT REQUIRED UNDER SAID ACT OR APPLICABLE STATE SECURITIES LAWS OR (II) UNLESS SOLD PURSUANT TO RULE 144 UNDER SAID
ACT. NOTWITHSTANDING THE FOREGOING, THE SECURITIES MAY BE PLEDGED IN CONNECTION WITH A BONA FIDE MARGIN ACCOUNT OR OTHER LOAN OR FINANCING ARRANGEMENT SECURED BY THE SECURITIES. ANY TRANSFEREE OF THIS NOTE SHOULD CAREFULLY REVIEW THE TERMS OF THIS
NOTE, INCLUDING SECTION 3(c)(viii) HEREOF. THE PRINCIPAL AMOUNT REPRESENTED BY THIS NOTE MAY BE LESS THAN THE AMOUNTS SET FORTH ON THE FACE HEREOF PURSUANT TO SECTION 3(c)(viii) HEREOF. ASSIGNEES OR TRANSFEREES OF THIS NOTE ARE BOUND BY THE TRADING
RESTRICTIONS OF SECTION 4(r) OF THE SECURITIES PURCHASE AGREEMENT (AS DEFINED HEREIN). 
 SENIOR SECURED NOTE 
  

			
	March 20, 2006	 	$[                    ]

 FOR VALUE RECEIVED, CARDIOVASCULAR BIOTHERAPEUTICS, INC., a Delaware corporation (the
“Company”), hereby promises to pay to the order of [                    ] or registered assigns (the
“Holder”) the principal amount of [                    ] United States Dollars
($[                    ]) when due, whether upon maturity, acceleration, redemption or otherwise, and to pay interest
(“Interest”) on the unpaid principal balance hereof on each Interest Payment Date (as defined in Section 2(a)) and upon maturity, or earlier upon conversion, acceleration or redemption pursuant to the terms hereof, at the
Applicable Interest Rate (as defined in Section 2(a)). Interest on this Note payable on each Interest Payment Date and upon maturity, or earlier upon conversion, acceleration or redemption pursuant to the terms hereof, shall accrue from the
Issuance Date (as defined in Section 2(a)) and shall be computed on the basis of a 365-day year and actual days elapsed. 
 (1) Payments of Principal. All payments of principal of this Note (to the extent such principal is not converted into Shares (as defined in Section 2(a)), in accordance with the terms hereof) shall be made in lawful money of the
United States of America by wire transfer of immediately available funds to such account as the Holder may from time to time designate by written notice in accordance with the provisions of this Note. Except as provided in Section 8, the
Company has no right, but under certain circumstances may have an obligation, to make payments of principal of this Note in cash prior to the Maturity Date (as defined in Section 2(a)). 

 
Whenever any amount expressed to be due by the terms of this Note is due on any day that is not a Business Day (as defined in Section 2(a)), the same
shall instead be due on the next succeeding day that is a Business Day. Each capitalized term used herein, and not otherwise defined, shall have the meaning ascribed thereto in the Securities Purchase Agreement, dated as of March 20, 2006,
pursuant to which this Note and the Other Notes (as defined in Section 2(a)) were originally issued (as such agreement may be amended from time to time as provided in such agreement, the “Securities Purchase Agreement”). This
Note and all Other Notes issued by the Company pursuant to the Securities Purchase Agreement and all notes issued in exchange therefor or replacement thereof are collectively referred to in this Note as the “Notes.” 
 (2) Definitions. 
 (a) Certain Defined Terms. For purposes of this Note, the following terms shall have the following meanings: 
 (i) “3-Month LIBOR Rate” means the London Interbank Offered Rate of LIBOR with respect to a three-month period for deposits of United States Dollars as reported by Bloomberg Financial Markets (or any
successor thereto, “Bloomberg”) at approximately 10:00 a.m. (New York time) through its “LIBOR Rates” function (accessed by typing “LR” [GO] on a Bloomberg terminal, and looking at the row entitled “3
MONTH” and under the column entitled “DOLLAR LIBOR”) (or such other page as may replace that page on that service, or such other service as may be selected jointly by the Company and the holders of the Notes). If such rate appears on
the Bloomberg LIBOR Rates page on any date of determination of the 3-Month LIBOR Rate (a “LIBOR Determination Date”), the 3-Month LIBOR Rate for such date of determination will be such rate. If on any LIBOR Determination Date such
rate does not appear on the Bloomberg LIBOR Rates page, the Company and the Holders of the Notes will jointly request each of four major reference banks in the London interbank market, as selected jointly by the Company and the Holders of the Notes,
to provide the Company with its offered quotation for United States dollar deposits for the upcoming three-month period, to prime banks in the London interbank market at approximately 4:00 p.m., London time on any such LIBOR Determination Date and
in a principal amount that is representative for a single transaction in United States Dollars in such market at such time. If at least two reference banks provide the Company with offered quotations, 3-Month LIBOR Rate on such LIBOR Determination
Date will be the arithmetic mean of all such quotations. If on such LIBOR Determination Date fewer than two of the reference banks provide the Company with offered quotations, 3-Month LIBOR Rate on such LIBOR Determination Date will be the
arithmetic mean of the offered per annum rates that three major banks in New York City selected jointly by the Company and the Holders of the Notes quote at approximately 11:00 A.M. in New York City on such LIBOR Determination Date for three-month
United States dollar loans to leading European banks, in a principal amount that is representative for a single transaction in United States dollars in such market at such time. If these New York City quotes are not available, then the 3-Month LIBOR
Rate determined on such LIBOR Determination Date will continue to be 

  

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3-Month LIBOR Rate as then currently in effect on such LIBOR Determination Date. 
 (ii) “Allocation Percentage” means, with respect to each holder of Notes as of the date of any determination, a fraction
of which the numerator is the aggregate principal amount of the Notes originally purchased by such holder on the Issuance Date, and of which the denominator is the aggregate principal amount of the Notes purchased by all holders on the Issuance
Date. 
 (iii) “Applicable Interest Rate” initially shall mean the per annum interest rate equal to the sum
of (a) the 3-Month LIBOR Rate in effect on the Issuance Date, and (b) seven percent (7.00%); provided, however, that on each Interest Payment Date, such rate shall be adjusted to the per annum interest rate equal to the sum of (a) the
3-Month LIBOR Rate in effect on such date, and (b) seven percent (7.00%). Each Applicable Interest Rate will be applicable as of and after the first date following such Interest Payment Date to which it relates to, and including the next
succeeding Interest Payment Date. 
 (iv) “Business Day” means any day other than Saturday, Sunday or other
day on which commercial banks in the city of New York are authorized or required by law to remain closed. 
 (v)
“Common Stock” means (A) the Company’s common stock, $0.001 par value per share, and (B) any capital stock resulting from a reclassification of such common stock. 
 (vi) “Conversion Amount” means (A) the sum of (1) the principal amount of this Note to be converted, redeemed
or otherwise with respect to which this determination is being made and (2) the Interest Amount with respect to the amount referred to in the immediately preceding clause (1), or (B) in the case of an Interest Conversion (as defined in
Section 7), the Interest Amount to be converted. 
 (vii) “Conversion Price” means, as of any
Conversion Date or other date of determination, the lesser of (A) the Fixed Conversion Price, and (B) 94% of the arithmetic average of the Weighted Average Price of the Common Stock on each of the five (5) consecutive Trading Days
immediately preceding the Conversion Date applicable to the conversion for which such determination is being made; provided, however, that at the election of the Holder as set forth in a Conversion Notice (as defined in Section 2(d)),
“Conversion Price” shall mean the Fixed Conversion Price. 
 (viii) “Dollars” or
“$” means United States Dollars. 
 (ix) “Excluded Taxes” means, with respect to the
Holder, or any other recipient of payment to be made by or on account of any obligations of the Company or any of its Subsidiaries under the Notes, the Securities Purchase Agreement or under any other Transaction Document, income or franchise taxes

  

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imposed on (or measured by) its net income by the United States of America or such other jurisdiction under the laws of which such recipient is organized or
its principal offices are located. 
 (x) “Expected Trading Days” means, with respect to any Company
Conversion Period (as defined in Section 9(a)), the number of regularly scheduled Business Days in such period on which the Principal Market is scheduled to be open for trading of the Common Stock. 
 (xi) “Fixed Conversion Price” means, as of any Conversion Date or other date of determination, $12.00, subject to
adjustment as provided herein. 
 (xii) “Indemnified Taxes” means Taxes other than Excluded Taxes.

 (xiii) “Initial Warrants” means the warrants issued to the original buyers of the Notes pursuant to the
Securities Purchase Agreement, and all warrants issued in exchange or substitution therefor or replacement thereof. 
 (xiv)
“Interest Amount” means, with respect to any Principal, all accrued and unpaid Interest (including any Default Interest as defined in Section 7) on such Principal through and including such date of determination. 
 (xv) “Interest Payment Date” means the first Business Day of each calendar quarter, beginning with the calendar quarter
that commences on April 1, 2006 through and including the last calendar quarter that commences prior to the Maturity Date. 
 (xvi) “Issuance Date” means the original date of issuance of this Note pursuant to the Securities Purchase Agreement, regardless of any exchange or replacement hereof. 
 (xvii) “Lien” means, with respect to any asset, any mortgage, lien, pledge, hypothecation, charge, security interest,
encumbrance or adverse claim of any kind and any restrictive covenant, condition, restriction or exception of any kind that has the practical effect of creating a mortgage, lien, pledge, hypothecation, charge, security
interest, encumbrance or adverse claim of any kind (including any of the foregoing created by, arising under or evidenced by any conditional sale or other title retention agreement, the interest of a lessor with respect to a Capital Lease
Obligation, or any financing lease having substantially the same economic effect as any of the foregoing). 
 (xviii)
“Maturity Date” means March 20, 2009, unless such date is not a Business Day, in which case “Maturity Date” shall mean the first Business Day following March 20, 2009. 
  

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 (xix) “Original Principal Amount” means
$[                    ] [INSERT: The Principal amount of this Note on the Issuance Date upon the Closing of the Securities Purchase
Agreement]. 
 (xx) “Other Notes” means all of the senior secured notes, other than this Note, that have
been issued by the Company pursuant to the Securities Purchase Agreement and all notes issued in exchange therefor or replacement thereof. 
 (xxi) “Permitted Lien” means (a) Liens created by the Security Documents; (b) Liens existing on the date of the Securities Purchase Agreement not otherwise described in any other clause of
this definition and set forth on Schedule 3(bb) to the Securities Purchase Agreement; (c) Liens for taxes or other governmental charges not at the time due and payable so long as the Company and its Subsidiaries maintain adequate
reserves in accordance with United States generally accepted accounting principles (“GAAP”) in respect of such taxes and charges; (d) Liens arising in the ordinary course of business in favor of carriers, warehousemen,
mechanics and materialmen, or other similar Liens imposed by law, which remain payable without penalty or which are being contested in good faith by appropriate proceedings diligently prosecuted, which proceedings have the effect of preventing the
forfeiture or sale of the property subject thereto, and in each case for which adequate reserves in accordance with GAAP are being maintained; (e) Liens arising in the ordinary course of business in connection with worker’s compensation,
unemployment compensation and other types of social security (excluding Liens arising under ERISA); (f) attachments, appeal bonds (and cash collateral securing such bonds), judgments and other similar Liens, for sums not exceeding $100,000 in
the aggregate for the Company and its Subsidiaries, arising in connection with court proceedings, provided that the execution or other enforcement of such Liens is effectively stayed; (g) easements, rights of way, restrictions, minor defects or
irregularities in title and other similar Liens arising in the ordinary course of business and not materially detracting from the value of the property subject thereto and not interfering in any material respect with the ordinary conduct of the
business of the Company or any Subsidiary; and (h) Liens arising solely by virtue of any statutory or common law provision relating to banker’s liens, rights of set-off or similar rights and remedies and burdening only deposit accounts or
other funds maintained with a creditor depository institution, provided that no such deposit account is a dedicated cash collateral account or is subject to restrictions against access by the depositor in excess of those set forth by regulations
promulgated by the Board of Governors of the Federal Reserve System and no such deposit account is intended by the Company or any Subsidiary to provide collateral to the depository institution. 
 (xxii) “Person” means an individual, a limited liability company, a partnership, a joint venture, a corporation, a
trust, an unincorporated organization or a government or any department or agency thereof or any other legal entity. 
  

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 (xxiii) “Principal” means the outstanding principal amount of this Note
as of any date of determination. 
 (xxiv) “Principal Market” means, with respect to the Common Stock or any
other security, the principal securities exchange or trading market for the Common Stock or such other security. 
 (xxv)
“Registrable Securities” shall have the meaning set forth in the Registration Rights Agreement. 
 (xxvi)
“Registration Rights Agreement” means that certain Registration Rights Agreement, dated as of March 20, 2006, among the Company and the initial holders of the Notes relating to the filing of registration statements covering,
among other things, the resale of the Registrable Securities, as such agreement may be amended from time to time as provided in such agreement. 
 (xxvii) “Registration Statement” means a registration statement or registration statements filed under the 1933 Act pursuant to the Registration Rights Agreement covering the resale of the Registrable
Securities. 
 (xxviii) “SEC” means the United States Securities and Exchange Commission, or any successor
thereto. 
 (xxix) “Security Agreement” means that certain security agreement among the Company, its
Subsidiaries, the Collateral Agent (as defined therein) and the holders of the Notes relating to the granting by the Company and the Subsidiaries of a first-priority security interest, subject to Permitted Liens, in all the assets of the Company and
its Subsidiaries, as such agreement may be amended from time to time as provided in such agreement. 
 (xxx)
“Security Documents” means the Security Agreement and any other agreements, documents and instruments executed concurrently herewith or at any time hereafter pursuant to which the Company, its Subsidiaries or any other Person either
(i) guarantees payment or performance of all or any portion of the obligations hereunder or under any other instruments delivered in connection with the transactions contemplated hereby and by the Securities Purchase Agreement, and/or
(ii) provides, as security for all or any portion of such obligations, a Lien on any of its assets in favor of the Holder, as any or all of the same may be amended, supplemented, restated or otherwise modified from time to time. 
 (xxxi) “Shares” means shares of Common Stock. 
 (xxxii) “Trading Day” means any day on which the Common Stock is traded on its Principal Market; provided that
“Trading Day” shall not include any day on which the Principal Market is open for trading for less than 4.5 hours. 
  

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 (xxxiii) “Weighted Average Price” means, for any security as of any
date, the dollar volume-weighted average price for such security on its Principal Market during the period beginning at 9:30 a.m. New York City time (or such other time as its Principal Market publicly announces is the official open of trading) and
ending at 4:00 p.m. New York City time (or such other time as its Principal Market publicly announces is the official close of trading) as reported by Bloomberg through its “Volume at Price” functions, or if the foregoing does not apply,
the dollar volume-weighted average price of such security in the over-the-counter market on the electronic bulletin board for such security during the period beginning at 9:30 a.m. New York City time (or such other time as such over-the-counter
market publicly announces is the official open of trading), and ending at 4:00 p.m. New York City time (or such other time as such over-the-counter market publicly announces is the official close of trading) as reported by Bloomberg, or, if no
dollar volume-weighted average price is reported for such security by Bloomberg for such hours, the average of the highest closing bid price and the lowest closing ask price of any of the market makers for such security as reported in the “pink
sheets” by the National Quotation Bureau, Inc. If the Weighted Average Price cannot be calculated for such security on such date on any of the foregoing bases, the Weighted Average Price of such security on such date shall be the fair market
value as mutually determined by the Company and the holders of Notes representing at least two-thirds (2/3) of the aggregate principal amount of the Notes then outstanding as to which such determination is being made. If the Company and the
holders of the Notes representing at least two-thirds (2/3) of the aggregate principal amount of the Notes then outstanding as to which such determination is being made are unable to agree upon the fair market value of the Common Stock, then
such dispute shall be resolved pursuant to Section 3(c)(iii) below with the term “Weighted Average Price” being substituted for the term “Conversion Price.” All such determinations shall be appropriately adjusted for any
stock dividend, stock split, stock combination or other similar transaction during any period during which the Weighted Average Price is being determined. 
 (3) Conversion of this Note; Mandatory Redemption at Maturity. This Note shall be converted into Shares on the terms and conditions set forth in this Section 3. 
 (a) Conversion at Option of the Holder. Subject to the provisions of Section 6, at any time or times on or after the Issuance
Date, the Holder shall be entitled to convert all or any part of the Principal (and the Interest Amount relating thereto) into fully paid and nonassessable Shares in accordance with this Section 3, at the Conversion Rate (as defined in
Section 3(b)). The Company shall not issue any fraction of a Share upon any conversion. If the issuance would result in the issuance of a fraction of a Share, then the Company shall round such fraction of a Share up or down to the nearest whole
share (with 0.5 rounded up). If any Principal remains outstanding on the Maturity Date, then all such Principal (and the Interest Amount relating thereto) shall be redeemed as of such date in accordance with Section 3(c)(vii). 
  

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 (b) Conversion Rate. The number of Shares issuable upon a conversion of any
portion of this Note pursuant to Section 3 shall be determined according to the following formula (the “Conversion Rate”): 
 Conversion Amount 
 Conversion Price 
 (c) Mechanics of Conversion. The conversion of this Note shall be conducted in the following manner: 
 (i) Holder’s Delivery Requirements. To convert a Conversion Amount into Shares on any date (the “Conversion
Date”), the Holder shall (A) transmit by facsimile (or otherwise deliver), for receipt on or prior to 11:59 p.m. New York City time on such date, a copy of an executed conversion notice in the form attached hereto as Exhibit I
(the “Conversion Notice”) to the Company (attention: Corporate Controller), and (B) if required by Section 3(c)(vii) or Section 3(c)(viii), surrender to a common carrier for delivery to the Company, no later than
three (3) Business Days after the Conversion Date, the original Note being converted (or an indemnification undertaking reasonably acceptable to the Company with respect to this Note in the case of its loss, theft or destruction). Such
Conversion Notice shall specify whether and in what amounts the Conversion Amount relates to (X) a conversion at the election of the Holder at the Fixed Conversion Price other than pursuant to Section 9, (Y) a conversion at the
election of the Holder other than at the Fixed Conversion Price and other than pursuant to Section 9, or (Z) a Company Conversion pursuant to Section 9 (including an Interest Conversion); and any such conversion shall be applied as so
specified. 
 (ii) Company’s Response. Upon receipt or deemed receipt by the Company of a copy of a Conversion
Notice, the Company (I) shall immediately send, via facsimile, a confirmation of receipt of such Conversion Notice to the Holder and the Company’s designated transfer agent (the “Transfer Agent”), which confirmation shall
constitute an instruction to the Transfer Agent to process such Conversion Notice in accordance with the terms herein and (II) on or before the second (2nd) Business Day following the date of receipt or deemed receipt by the Company of such Conversion Notice (the “Share Delivery Date”) (A) provided that the Transfer Agent is
participating in The Depository Trust Company (“DTC”) Fast Automated Securities Transfer Program and provided that the Holder is eligible to receive Shares through DTC, credit such aggregate number of Shares to which the Holder
shall be entitled to the Holder’s or its designee’s balance account with DTC through its Deposit Withdrawal Agent Commission system, or (B) if the foregoing shall not apply, issue and deliver to the address as specified in the
Conversion Notice, a certificate, registered in the name of the Holder or its designee, for the number of Shares to which the Holder shall be entitled. If this Note is submitted for conversion, as may be required by Section 3(c)(viii), and the
Principal represented by this Note is greater than the Principal being converted, then the Company shall, as soon as practicable and in 

  

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no event later than three (3) Business Days after receipt of this Note (the “Note Delivery Date”) and at its own expense, issue and
deliver to the Holder a new Note representing the Principal not converted and cancel this Note. 
 (iii) Dispute
Resolution. In the case of a dispute as to the determination of the Conversion Price or the arithmetic calculation of the Conversion Rate, the Company shall instruct the Transfer Agent to issue to the Holder the Shares representing the number of
Shares that is not disputed and shall transmit an explanation of the disputed determinations or arithmetic calculations to the Holder via facsimile within two (2) Business Day of receipt or deemed receipt of the Holder’s Conversion Notice
or other date of determination. If the Holder and the Company are unable to agree upon the determination of the Conversion Price or arithmetic calculation of the Conversion Rate within one (1) Business Day of such disputed determination or
arithmetic calculation being transmitted to the Holder, then the Company shall promptly (and in any event within two (2) Business Days) submit via facsimile (A) the disputed determination of the Conversion Price to an independent,
reputable investment banking firm agreed to by the Company and the holders of the Notes representing at least two-thirds (2/3) of the aggregate principal amounts of the Notes then outstanding as to which such determination is being made, or
(B) the disputed arithmetic calculation of the Conversion Rate to the Company’s independent, outside accountant, as the case may be. The Company shall direct the investment bank or the accountant, as the case may be, to perform the
determinations or calculations and notify the Company and the Holder of the results no later than two (2) Business Days from the time it receives the disputed determinations or calculations. Such investment bank’s or accountant’s
determination or calculation, as the case may be, shall be binding upon all parties absent demonstrable error. 
 (iv)
Record Holder. The person or persons entitled to receive the Shares issuable upon a conversion of this Note shall be treated for all purposes as the legal and record holder or holders of such Shares on the Conversion Date. 
 (v) Company’s Failure to Timely Convert. 
 (A) Cash Damages. If within three (3) Business Days after the Company’s receipt of the facsimile copy of a Conversion
Notice or deemed receipt of a Conversion Notice the Company shall fail to issue and deliver a certificate to the Holder for, or credit the Holder’s or its designee’s balance account with DTC with, the number of Shares to which the Holder
is entitled upon the Holder’s conversion of any Conversion Amount, or if the Company fails to issue and deliver a new Note representing the Principal to which such Holder is entitled on or before the Note Delivery Date pursuant to
Section 3(c)(ii), then in addition to all other available remedies that the Holder may pursue hereunder and under the Securities Purchase Agreement (including indemnification pursuant to Section 8 thereof or at law or in equity), the
Company shall pay additional damages to the Holder for each day after the Share Delivery Date such conversion is not timely effected and/or each day after the Note Delivery Date such Note is not delivered in an amount equal to 0.5% of the sum of
(a) the product of (I) the number of 

  

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Shares not issued to the Holder or its designee on or prior to the Share Delivery Date and to which the Holder is entitled and (II) the Weighted Average
Price of the Common Stock on the Share Delivery Date (such product is referred to herein as the “Share Product Amount”), and (b) in the event the Company has failed to deliver a Note to the Holder on or prior to the Note
Delivery Date, the product of (y) the number of Shares issuable upon conversion of the Principal represented by the Note as of the Note Delivery Date and (z) the Weighted Average Price of the Common Stock on the Note Delivery Date;
provided that in no event shall cash damages accrue pursuant to this Section 3(c)(v)(A) with respect to the Share Product Amount during the period, if any, in which the Conversion Price or the arithmetic calculation of the Conversion Rate is
subject to a bona fide dispute that is subject to and being resolved pursuant to, and in compliance with the time periods and other provisions of, the dispute resolution provisions of Section 3(c)(iii), provided that the Shares are delivered to
the Holder within one (1) Business Day of the resolution of such bona fide dispute. Alternatively, subject to Section 3(c)(iii), at the election of the Holder made in the Holder’s sole discretion, the Company shall pay to the Holder,
in lieu of the additional damages referred to in the preceding sentence (but in addition to all other available remedies that the Holder may pursue hereunder and under the Securities Purchase Agreement (including indemnification pursuant to
Section 8 thereof or at law or in equity)), 110% of the amount by which (A) the Holder’s total purchase price (including brokerage commissions, if any) for the Shares purchased to make delivery in satisfaction of a sale by the Holder
of the Shares to which the Holder is entitled but has not received upon a conversion exceeds (B) the net proceeds received by the Holder from the sale of the Shares to which the Holder is entitled but has not received upon such conversion. If
the Company fails to pay the additional damages set forth in this Section 3(c)(v)(A) within five (5) Business Days of the date incurred, then the Holder entitled to such payments shall have the right at any time, so long as the Company
continues to fail to make such payments, to require the Company, upon written notice, to immediately issue, in lieu of such cash damages, the number of Shares equal to the quotient of (X) the aggregate amount of the damages payments described
herein divided by (Y) the Conversion Price in effect on such Conversion Date as specified by the Holder in the Conversion Notice. 
 (B) Void Conversion Notice. If for any reason the Holder has not received all of the Shares prior to the tenth (10th) Business Day after the Share Delivery Date with respect to a conversion of this Note,
other than due to the limitation contained in Section 6(b) or to the pendency of a dispute being resolved in accordance with Section 3(c)(iii) (a “Conversion Failure”), then the Holder, upon written notice to the Company
(a “Void Conversion Notice”), may void its Conversion Notice with respect to, and retain or have returned, as the case may be, any portion of this Note that has not been converted pursuant to the Holder’s Conversion Notice;
provided that the voiding of the Holder’s Conversion Notice shall not affect the Company’s obligations to make any payments that have accrued prior to the date of such notice pursuant to Section 3(c)(v)(A) or otherwise. 
 (C) Redemption. In the event of a Conversion Failure, the Holder, upon written notice to the Company, may require that the Company
redeem, in accordance with Section 4, all of the Principal, including the Principal previously submitted for conversion and with respect to which the Company has not delivered shares of Common Stock; provided that the Holder shall not be
entitled to require redemption of any Principal pursuant to this clause (C) solely as a result of a Conversion Failure caused by any Principal being the 

  

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subject of a bona fide dispute that is subject to and being resolved pursuant to, and in compliance with the time periods and other provisions of, the
dispute resolution provisions of Section 3(c)(iii), provided the Shares are delivered to the Holder within one (1) Business Day following the resolution of such bona fide dispute. 
 (vi) Pro Rata Conversion. In the event the Company receives a Conversion Notice from more than one holder of the Notes for the
same Conversion Date and the Company can convert some, but not all, of such Notes, then, subject to Section 6(c), the Company shall convert from each holder of the Notes electing to have Notes converted at such time a pro rata amount of such
holder’s Note submitted for conversion based on the principal amount of the Note submitted for conversion on such date by such holder relative to the aggregate principal amount of the Notes submitted for conversion on such date. 
 (vii) Mechanics of Mandatory Redemption. If any Principal remains outstanding on the Maturity Date, then the Holder shall
surrender this Note, duly endorsed for cancellation, to the Company, and such Principal shall be redeemed by the Company as of the Maturity Date by payment on the Maturity Date to the Holder of an amount equal to the sum of (A) 100% of such
Principal plus (B) the Interest Amount with respect to such Principal. 
 (viii) Book-Entry. Notwithstanding
anything to the contrary set forth herein, upon conversion of this Note in accordance with the terms hereof, the Holder shall not be required to physically surrender this Note to the Company unless all of the Principal is being converted. The Holder
and the Company shall maintain records showing the Principal converted or redeemed and the dates of such conversions or redemptions or shall use such other method, reasonably satisfactory to the Holder and the Company, so as not to require physical
surrender of this Note upon each such conversion or redemption. In the event of any dispute or discrepancy, such records of the Company establishing the Principal to which the Holder is entitled shall be controlling and determinative in the absence
of demonstrable error. Notwithstanding the foregoing, if this Note is converted or redeemed as aforesaid, the Holder may not transfer this Note unless the Holder first physically surrenders this Note to the Company, whereupon the Company will
forthwith issue and deliver upon the order of the Holder a new Note of like tenor, registered as the Holder may request, representing in the aggregate the remaining Principal represented by this Note. The Holder and any assignee, by acceptance of
this Note, acknowledge and agree that, by reason of the provisions of this paragraph, following conversion or redemption of any portion of this Note, the Principal of this Note may be less than the principal amount stated on the face hereof.

 (d) Taxes. The Company shall pay any and all taxes (excluding income taxes, franchise taxes or other taxes levied on
gross earnings, profits or the like of the Holder) that may be payable with respect to the issuance and delivery of Shares upon the conversion of this Note. 
  

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 (e) Adjustments to Fixed Conversion Price. The Fixed Conversion Price will be
subject to adjustment from time to time as provided in this Section 3(e). 
 (i) Adjustment of Fixed Conversion Price
upon Issuance of Common Stock. If and whenever on or after the Issuance Date, the Company issues or sells, or in accordance with this Section 3(e)(i) is deemed to have issued or sold, any Shares (including the issuance or sale of Shares
owned or held by or for the account of the Company, but excluding Exempted Issuances (as defined below)) for a consideration per share less than a price (the “Applicable Price”) equal to the Fixed Conversion Price in effect
immediately prior to such time, then immediately after such issue or sale, the Fixed Conversion Price then in effect shall be reduced to an amount equal to such consideration per share. For purposes of determining the adjusted Fixed Conversion Price
under this Section 3(e)(i) (which, for the avoidance of doubt, the Company and the Holder agree shall mean for all purposes of this Section 3(e), including for purposes of determining whether the Company has issued or sold, or shall be
deemed to have issued or have sold, any Shares for a consideration per share less than a price equal to the Applicable Price), the following shall be applicable: 
 (A) Issuance of Options. If the Company in any manner grants or sells any Options (as defined below) and the lowest price per
share for which one Share is issuable upon the exercise of any such Option or upon conversion, exchange or exercise of any Convertible Securities (as defined below) issuable upon exercise of such Option is less than the Applicable Price, then such
Share shall be deemed to be outstanding and to have been issued and sold by the Company at the time of the granting or sale of such Option for such price per share. For purposes of this Section 3(e)(i)(A), the “lowest price per share for
which one Share is issuable upon the exercise of any such Option or upon conversion, exchange or exercise of any Convertible Securities issuable upon exercise of such Option” shall be equal to the sum of the lowest amounts of consideration (if
any) received or receivable by the Company with respect to any one Share upon granting or sale of the Option, upon exercise of the Option and upon conversion, exchange or exercise of any Convertible Security issuable upon exercise of such Option. No
further adjustment of the Fixed Conversion Price shall be made upon the actual issuance of such Share or of such Convertible Securities upon the exercise of such Options or upon the actual issuance of such Share upon conversion, exchange or exercise
of such Convertible Securities. 
 (B) Issuance of Convertible Securities. If the Company in any manner issues or
sells any Convertible Securities and the lowest price per share for which one Share is issuable upon such conversion, exchange or exercise thereof is less than the Applicable Price, then such Share shall be deemed to be outstanding and to have been
issued and sold by the Company at the time of the issuance or sale of such Convertible Securities for such price per share. For the purposes of this Section 3(e)(i)(B), the “lowest price per share for which one Share is issuable upon such
conversion, exchange or exercise” shall be equal to the sum of the lowest amounts of consideration (if any) received or receivable by the Company with respect to any one Share upon the issuance or sale of the Convertible Security and upon the
conversion, exchange or exercise of such Convertible Security. No further adjustment of the Fixed Conversion Price shall be made upon the actual issuance of such Share upon conversion, 

  

 12 

 
exchange or exercise of such Convertible Securities, and if any such issue or sale of such Convertible Securities is made upon exercise of any Options for
which adjustment of the Fixed Conversion Price had been or are to be made pursuant to other provisions of this Section 3(e)(i), then no further adjustment of the Fixed Conversion Price shall be made by reason of such issue or sale. 

(C) Change in Option Price or Rate of Conversion. If the purchase, exchange or exercise price provided for in any Options, the
additional consideration, if any, payable upon the issue, conversion, exchange or exercise of any Convertible Securities, or the rate at which any Options or Convertible Securities are convertible into or exchangeable or exercisable for Shares
changes at any time, then the Fixed Conversion Price in effect at the time of such change shall be adjusted to the Fixed Conversion Price that would have been in effect at such time had such Options or Convertible Securities provided for such
changed purchase, exchange or exercise price, additional consideration or changed conversion rate, as the case may be, at the time initially granted, issued or sold. For purposes of this Section 3(e)(i)(C), if the terms of any Option or
Convertible Security that was outstanding as of the Issuance Date are changed in the manner described in the immediately preceding sentence, then such Option or Convertible Security and the Shares deemed issuable upon exercise, conversion or
exchange thereof shall be deemed to have been issued as of the date of such change. No adjustment shall be made if such adjustment would result in an increase of the Fixed Conversion Price then in effect. 
 (D) Calculation of Consideration Received. In case any Options are issued in connection with the issue or sale of other securities
of the Company, together comprising one integrated transaction or series of related transactions, (A) the Options will be deemed to have been issued for a consideration equal to the greatest of (I) $0.01, (II) the specific aggregate
consideration, if any, allocated to such Options, and (III) the Black-Scholes Value (as defined below) of such Options (the greatest of (I), (II) and (III), the “Option Consideration”) and, for purposes of applying the provisions of
this Section 3(e), the Option Consideration shall be allocated pro rata among all the shares of Common Stock issuable upon exercise of such Options to determine the consideration per share of Common Stock, and (B) the other securities will
be deemed to have been issued for an aggregate consideration equal to the aggregate consideration received by the Company for the Options and other securities (determined as provided below), less the Option Consideration. If any Shares, Options or
Convertible Securities are issued or sold or deemed to have been issued or sold for cash, the consideration received therefor will be deemed to be the net amount received by the Company therefor. If any Shares, Options or Convertible Securities are
issued or sold for a consideration other than cash, the amount of the consideration other than cash received by the Company will be the fair value of such consideration, except where such consideration received by the Company consists of marketable
securities, in which case the amount of consideration received by the Company will be the Weighted Average Price of such securities on the date of receipt of such securities. If any Shares, Options or Convertible Securities are issued to the owners
of the non-surviving entity in connection with any merger in which the Company is the surviving entity, the amount of consideration therefor will be deemed to be the fair value of such portion of the net assets and business of the non-surviving
entity as is attributable to such Shares, Options or Convertible Securities, as the case may be. The fair value of any consideration other than cash or securities will be determined jointly by the Company and the holders of Notes and the 

  

 13 

 
Initial Warrants and Repurchase Warrants (as defined in Section 8), if any, representing at least two-thirds (2/3) of the aggregate number of
shares of Common Stock obtainable upon conversion of the Notes (at the then prevailing Fixed Conversion Price) then outstanding and exercise of the Initial Warrants and the Repurchase Warrants, if any (at the then prevailing exercise prices
thereof), then outstanding, without regard to any limitations on conversion or exercise thereof. If such parties are unable to reach agreement within ten (10) days after the occurrence of an event requiring valuation (the “Valuation
Event”), the fair value of such consideration will be determined within five (5) Business Days after the tenth (10th) day following the Valuation Event by an independent, reputable appraiser selected jointly by the Company and the
holders of Notes and the Initial Warrants and Repurchase Warrants, if any, representing at least two-thirds (2/3) of the aggregate number of shares of Common Stock obtainable upon conversion of the Notes (at the then prevailing Fixed Conversion
Price) then outstanding and exercise of the Initial Warrants and the Repurchase Warrants, if any (at the then prevailing exercise prices thereof), then outstanding, without regard to any limitations on conversion or exercise thereof. The
determination of such appraiser shall be final and binding upon all parties absent error, and the fees and expenses of such appraiser shall be borne by the Company. 
 (E) Record Date. If the Company takes a record of the holders of Shares for the purpose of entitling them (1) to receive a
dividend or other distribution payable in Shares, Options or in Convertible Securities or (2) to subscribe for or purchase Shares, Options or Convertible Securities, then such record date will be deemed to be the date of the issue or sale of
the Shares deemed to have been issued or sold upon the declaration of such dividend or the making of such other distribution or the date of the granting of such right of subscription or purchase, as the case may be. 
 (F) Certain Definitions. For purposes of this Section 3(e), the following terms have the respective meanings set forth below:

 (I) “Approved Stock Plan” means any employee benefit plan that has been approved by the Board of
Directors and stockholders of the Company prior to the date of the Securities Purchase Agreement and listed on Schedule 3(c) thereto, pursuant to which the Company’s securities may be issued to any consultant, employee, officer or
director for services provided to the Company. 
 (II) “Black-Scholes Value” of any Options shall mean the
sum of the amounts resulting from applying the Black-Scholes pricing model to each such Option, which calculation is made with the following inputs: (i) the “option striking price” being equal to the lowest exercise price
possible under the terms of such Option on the date of the issuance of such Option (the “Valuation Date”), (ii) the “interest rate” being equal to the Federal Reserve US H.15 T Note Treasury Constant Maturity 1 Year
rate on the Valuation Date (as reported by Bloomberg through its “ALLX H15T” function (accessed by typing “ALLX H15T” [GO] on a Bloomberg terminal, and inserting the date of the Valuation Date and then looking at the row entitled
“Treas Const Mat 1 Year” under the column entitled “Previous Value”)), or if such rate is not available then such other similar rate as mutually agreed to by the Company and the holders of Notes and the Initial Warrants and
Repurchase Warrants, if any, representing at least two-thirds (2/3) of the aggregate number of shares of Common Stock 

  

 14 

 
obtainable upon conversion of the Notes (at the then prevailing Fixed Conversion Price) then outstanding and exercise of the Initial Warrants and the
Repurchase Warrants, if any (at the then prevailing exercise prices thereof), then outstanding, without regard to any limitations on conversion or exercise thereof, (iii) the “time until option expiration” being the time from the
Valuation Date until the expiration date of such Option, (iv) the “current stock price” being equal to the Weighted Average Price of the Common Stock on the Valuation Date, (v) the “volatility” being the 100-day
historical volatility of the Common Stock as of the Valuation Date (as reported by the Bloomberg “HVT” screen), and (vi) the “dividend rate” being equal to zero. Within three (3) Business Days after the Valuation Date,
each of the Company and the Holder shall deliver to the other a written calculation of its determination of the Black-Scholes Value of the Options. If the Holder and the Company are unable to agree upon the calculation of the Black-Scholes Value of
the Options within five (5) Business Days of the Valuation Date, then the Company shall submit via facsimile the disputed calculation to an investment banking firm (selected jointly by the Company and the holders of Notes and the Initial
Warrants and Repurchase Warrants, if any, representing at least two-thirds (2/3) of the aggregate number of shares of Common Stock obtainable upon conversion of the Notes (at the then prevailing Fixed Conversion Price) then outstanding and
exercise of the Initial Warrants and the Repurchase Warrants, if any (at the then prevailing exercise prices thereof), then outstanding, without regard to any limitations on conversion or exercise thereof) within seven (7) Business Days of the
Valuation Date. The Company shall cause such investment banking firm to perform the calculations and notify the company and the Holder of the results no later than ten (10) Business Days after the Valuation Date. Such investment banking
firm’s calculation of the Black-Scholes Value of the Options shall be deemed conclusive absent error. The Company shall bear the fees and expenses of such investment banking firm for providing such calculation. 
 (III) “Convertible Securities” means any stock or securities (other than Options) directly or indirectly convertible
into or exchangeable or exercisable for Shares. 
 (IV) “Exempted Issuances” shall mean: (A) Shares
issued or deemed to have been issued by the Company pursuant to an Approved Stock Plan; (B) Shares issued or deemed to have been issued upon the conversion, exchange or exercise of any Option or Convertible Security outstanding on the date
prior to the Issuance Date and set forth in Schedule 3(c) to the Securities Purchase Agreement, provided that the terms of such Option or Convertible Security are not amended or otherwise modified on or after the date of the Securities
Purchase Agreement, and provided that the conversion price, exchange price, exercise price or other purchase price is not reduced, adjusted or otherwise modified and the number of Shares issued or issuable is not increased (whether by operation of,
or in accordance with, the relevant governing documents or otherwise) on or after the date of the Securities Purchase Agreement; and (C) Shares issued or deemed to have been issued by the Company upon conversion of the Notes or exercise of the
Initial Warrants or the Repurchase Warrants 
 (V) “Options” means any rights, warrants or options to
subscribe for or purchase Shares or Convertible Securities. 
 (ii) Adjustment of Fixed Conversion Price upon Subdivision
or Combination of Common Stock. If the Company at any time on or after the 

  

 15 

 
Issuance Date subdivides (by any stock split, stock dividend, recapitalization or otherwise) outstanding Shares into a greater number of shares, the Fixed
Conversion Price in effect immediately prior to such subdivision will be proportionately reduced. If the Company at any time on or after the Issuance Date combines (by combination, reverse stock split or otherwise) its outstanding Shares into a
smaller number of shares, the Fixed Conversion Price in effect immediately prior to such combination will be proportionately increased. 
 (iii) Other Events. If any event occurs of the type contemplated by the provisions of this Section 3(e) but not expressly provided for by such provisions (including the granting of stock appreciation
rights, phantom stock rights or other rights with equity features), then the Company’s Board of Directors will make an appropriate adjustment in the Conversion Price so as to protect the rights of the Holder; provided that no such adjustment
will increase the Conversion Price as otherwise determined pursuant to this Section 3(e). 
 (iv) Notices.
Promptly upon any adjustment of the Conversion Price, the Company will give written notice thereof to the Holder, setting forth in reasonable detail, and certifying, the calculation of such adjustment. The Company will give written notice to the
Holder at least ten (10) Business Days prior to the date on which the Company closes its books or takes a record (I) with respect to any dividend or distribution upon the Common Stock, (II) with respect to any pro rata subscription offer
to holders of Common Stock or (III) for determining rights to vote with respect to any Organic Change (as defined in Section 5(a)), dissolution or liquidation, provided that such information shall be made known to the public prior to or in
conjunction with such notice being provided to the Holder. The Company will also give written notice to the Holder at least ten (10) Business Days prior to the date on which any Organic Change, dissolution or liquidation will take place,
provided that such information shall be made known to the public prior to or in conjunction with such notice being provided to the Holder. 
 (4) Redemption at Option of the Holder. 
 (a) Redemption Option Upon Triggering
Event. In addition to all other rights of the Holder contained herein, after a Triggering Event (as defined in Section 4(b)), the Holder shall have the right, at the Holder’s option, to require the Company to redeem all or a portion of
the Principal at a price (“Redemption Price”) equal to the sum of (i) 120% of such Principal plus (ii) the Interest Amount with respect to such Principal. 
 (b) Triggering Event. A “Triggering Event” shall be deemed to have occurred at such time as any of the following
events: 
 (i) the failure of any Registration Statement (as defined in the Registration Rights Agreement) required to be
filed pursuant to Section 2(a) or Section 2(e) of the Registration Rights Agreement to be declared effective by the 

  

 16 

 
SEC on or prior to the date that is 45 days after the applicable Effectiveness Deadline (as defined in the Registration Rights Agreement); 
 (ii) while a Registration Statement filed pursuant to Section 2(a) or Section 2(e) of the Registration Rights Agreement is
required to be maintained effective pursuant to the terms of the Registration Rights Agreement, the effectiveness of such Registration Statement lapses for any reason (including the issuance of a stop order) or is unavailable to the Holder for sale
of Registrable Securities (as defined in the Registration Rights Agreement) in accordance with the terms of the Registration Rights Agreement, and such lapse or unavailability continues for a period of five (5) consecutive Trading Days or for
more than an aggregate of ten (10) Trading Days in any 365-day period (other than days during an Allowable Grace Period (as defined in the Registration Rights Agreement)); 
 (iii) the Common Stock is not listed on the OTC Bulletin Board or listed on a national securities exchange or the NASDAQ National Market
(or successor thereto) or the NASDAQ Capital Market, or if the Common Stock has been listed on a national securities exchange or on the NASDAQ National Market (or successor thereto) or the NASDAQ Capital Market, the trading of the Common Stock on
such exchange or market is terminated or suspended for a period of five (5) consecutive Trading Days or for more than an aggregate of ten (10) Trading Days in any 365-day period; 
 (iv) the Company’s or the Transfer Agent’s notice to any holder of the Notes, including by way of public announcement, at any
time, of its intention not to comply with a request for conversion of any Notes into Shares that is tendered in accordance with the provisions of the Notes (excluding, however, a notice that relates solely to a bona fide dispute that is subject to
and being resolved pursuant to, and in compliance with the time periods and other provisions of the dispute resolution provisions of Section 3(c)(iii), provided neither such dispute nor such notice is publicly disclosed); 
 (v) a Conversion Failure; 
 (vi) upon the Company’s receipt or deemed receipt of a Conversion Notice, the Company not being obligated to issue Shares upon such conversion due to the provisions of Section 6(c). 
 (vii) the Company or any of its Subsidiaries breaches any representation, warranty, covenant or other term or condition of the Securities
Purchase Agreement, the Registration Rights Agreement, the Initial Warrants or the Repurchase Warrants, if any, this Note, the Security Documents or any other agreement, document, certificate or other instrument delivered in connection with the
transactions contemplated thereby and hereby, except to the extent that such breach would not have a Material Adverse Effect (as defined in Section 3(a) of the Securities Purchase Agreement) and except, in the case of a breach of a 

  

 17 

 
covenant or other term that is curable, only if such breach continues for a period of at least twenty (20) days; or 
 (viii) the Company does not comply with the provisions of Sections 13 or 14 hereof or Section 4(j), 4(l), 4(n), 4(o), 4(p), 4(q) or
4(s) of the Securities Purchase Agreement. 
 (c) Mechanics of Redemption at Option of Holder. Within one
(1) Business Day after the occurrence of a Triggering Event, the Company shall deliver written notice thereof via facsimile and overnight courier (“Notice of Triggering Event”) to the Holder and each holder of the Other Notes.
At any time after the earlier of the Holder’s receipt of a Notice of Triggering Event and the Holder’s becoming aware of a Triggering Event, the Holder may require the Company to redeem up to all of the Principal by delivering written
notice thereof via facsimile and overnight courier (“Notice of Redemption at Option of Holder”) to the Company, which Notice of Redemption at Option of Holder shall indicate (i) the Principal that the Holder is electing to have
the Company redeem from it and (ii) the applicable Redemption Price, as calculated pursuant to Section 4(a) above; provided that a Notice of Redemption at Option of Holder may only be sent during the period beginning on and including the
date of the Triggering Event and ending on and including the date which is the later of (I) twenty (20) Business Days after the date on which the Holder receives a Notice of Triggering Event from the Company with respect to such Triggering
Event and (II) ten (10) Business Days after the date on which such Triggering Event is cured and the Holder receives written notice from the Company confirming such Triggering Event has been cured. 
 (d) Payment of Redemption Price. Upon the Company’s receipt of a Notice(s) of Redemption at Option of the Holder from any
holder of the Other Notes, the Company shall promptly notify the Holder by facsimile of the Company’s receipt of such notice(s). Each holder that has sent such a notice shall, if required pursuant to Section 3(c)(viii), promptly submit to
the Company such holder’s Note that such holder has elected to have redeemed. The Company shall deliver the applicable Redemption Price to the Holder within five (5) Business Days after the Company’s receipt of a Notice of Redemption
at Option of Holder, provided that the Holder’s Note shall have been so delivered to the Company. If the Company is unable to redeem all of the Notes submitted for redemption, the Company shall (i) redeem a pro rata amount from each holder
of the Notes based on the principal amount of the Notes submitted for redemption by such holder relative to the aggregate principal amount of the Notes submitted for redemption by all holders of the Notes, and (ii) in addition to any remedy the
Holder may have under this Note, the Securities Purchase Agreement and the Security Documents, pay to the Holder interest at a rate equal to the lesser of 2.0% per month (prorated for partial months) or the highest lawful interest rate in
respect of the unredeemed Principal until paid in full or until delivery of a Void Optional Redemption Notice (as defined in Section 4(e)). 
 (e) Void Redemption. In the event that the Company does not pay the Redemption Price within the time period set forth in Section 4(d), at any time thereafter and until the Company pays such unpaid
Redemption Price in full, the Holder shall have the option (the “Void Optional Redemption Option”) to, in lieu of redemption, require the Company to promptly return to the Holder any or all of the Notes or any portion thereof
representing the Principal that was submitted for redemption by the Holder under this Section 4 and for which the 

  

 18 

 
Redemption Price (together with any interest thereon) has not been paid, by sending written notice thereof to the Company via facsimile (the “Void
Optional Redemption Notice”). Upon the Company’s receipt of such Void Optional Redemption Notice, (i) the Notice of Redemption at Option of Holder shall be null and void with respect to the Principal subject to the Void Optional
Redemption Notice, (ii) the Company shall immediately return to the Holder any Note subject to the Void Optional Redemption Notice, and (iii) the Fixed Conversion Price with respect to all the Principal shall be adjusted to the
lesser of (A) the Fixed Conversion Price as in effect on the date on which the Void Optional Redemption Notice is delivered to the Company and (B) the lowest Weighted Average Price of the Common Stock during the period beginning on and
including the date on which the Notice of Redemption at Option of Holder is delivered to the Company and ending on and including the date on which the Void Optional Redemption Notice is delivered to the Company. 
 (f) Disputes; Miscellaneous. In the event of a bona fide dispute as to the determination of the arithmetic calculation of the
Redemption Price, such dispute shall be resolved pursuant to Section 3(c)(iii) above, with the term “Redemption Price” being substituted for the term “Conversion Rate.” A holder’s delivery of a Void Optional Redemption
Notice and exercise of its rights following such notice shall not affect the Company’s obligations to make any payments that have accrued prior to the date of such notice. In the event of a redemption pursuant to this Section 4 of less
than all of the Principal, the Company shall promptly cause to be issued and delivered to the Holder a Note representing the remaining Principal that has not been redeemed, if necessary. 
 (5) Other Rights of the Holder. 
 (a) Reorganization, Reclassification, Consolidation, Merger or Sale. Any recapitalization, reorganization, reclassification, consolidation, merger, sale of all or substantially all of the Company’s assets
to another Person or other transaction that is effected in such a way that holders of Common Stock are entitled to receive (either directly or upon subsequent liquidation) stock, securities or assets with respect to or in exchange for Common Stock
is referred to herein as “Organic Change.” Prior to the consummation of any (i) sale of all or substantially all of the Company’s assets to an acquiring Person (including, for the avoidance of doubt, the sale of all or
substantially all of the assets of the Company’s Subsidiaries in the aggregate) or (ii) other Organic Change following which the Company is not a surviving entity, the Company will secure from the Person purchasing such assets or the
successor resulting from such Organic Change (in each case, the “Acquiring Entity”) a written agreement, in form and substance satisfactory to the holders representing at least two-thirds (2/3) of the aggregate principal amount
of the Notes then outstanding, to deliver to the Holder in exchange for this Note, a security of the Acquiring Entity evidenced by a written instrument substantially similar in form and substance to this Note and satisfactory to the holders
representing at least two-thirds (2/3) of the aggregate principal amount of the Notes then outstanding. Prior to the consummation of any other Organic Change, the Company shall make appropriate provision (in form and substance satisfactory to
the holders representing at least two-thirds (2/3) of the aggregate principal amount of the Notes then outstanding) to ensure that the Holder will thereafter have the right to acquire and receive in lieu of or in addition to (as the case may
be) the Shares immediately theretofore acquirable and receivable upon the conversion of this Note (without regard to any limitations or restrictions on conversion) such shares of stock, securities 

  

 19 

 
or assets that would have been issued or payable in such Organic Change with respect to or in exchange for the number of Shares that would have been
acquirable and receivable upon the conversion of this Note as of the date of such Organic Change (without taking into account any limitations or restrictions on the conversion of this Note). 
 (b) Optional Redemption Upon Change of Control. In addition to the rights of the Holder under Section 5(a), upon a Change of
Control (as defined below) of the Company the Holder shall have the right, at the Holder’s option, to require the Company to redeem all or a portion of the Principal at a price equal to 110% (or 115% in the case of an event satisfying the
definition of Change of Control pursuant to subsection (iii) below) of the Principal plus the Interest Amount with respect to such Principal (the “Change of Control Redemption Price”). No sooner than thirty (30) nor later
than fifteen (15) Business Days prior to the consummation of a Change of Control, but not prior to the public announcement of such Change of Control, the Company shall deliver written notice thereof via facsimile and overnight courier (a
“Notice of Change of Control”) to the Holder. At any time during the period beginning after receipt of a Notice of Change of Control (or, in the event a Notice of Change of Control is not delivered at least twenty (20) Business
Days prior to a Change of Control, at any time on or after the date which is twenty (20) Business Days prior to a Change of Control) and ending on the date of such Change of Control, the Holder may require the Company to redeem all or a portion
of the Principal by delivering written notice thereof via facsimile and overnight courier (a “Notice of Redemption Upon Change of Control”) to the Company, which Notice of Redemption Upon Change of Control shall indicate
(i) the Principal that the Holder is submitting for redemption, and (ii) the applicable Change of Control Redemption Price, as calculated pursuant to this Section 5(b). Upon the Company’s receipt of a Notice(s) of Redemption Upon
Change of Control from any holder of the Other Notes, the Company shall promptly, but in no event later than one (1) Business Day following such receipt, notify the Holder by facsimile of the Company’s receipt of such Notice(s) of
Redemption Upon Change of Control. The Company shall deliver the Change of Control Redemption Price simultaneously with the consummation of the Change of Control; provided that, if required by Section 3(c)(viii), this Note shall have been so
delivered to the Company. The Company shall not enter into any binding agreement or other arrangement with respect to a Change of Control unless the Company provides that the payments provided for in this Section 5(b) shall have priority to
payments to stockholders in connection with such Change of Control and the Company complies with such provision. For purposes of this Section 5(b), “Change of Control” means (i) the consolidation, merger or other business
combination of the Company with or into another Person (other than (A) a consolidation, merger or other business combination in which holders of the Company’s voting power immediately prior to the transaction continue after the transaction
to hold, directly or indirectly, a majority of the combined voting power of the surviving entity or entities entitled to vote generally for the election of a majority of the members of the board of directors (or their equivalent if other than a
corporation) of such entity or entities, or (B) pursuant to a migratory merger effected solely for the purpose of changing the jurisdiction of incorporation of the Company), (ii) the sale or transfer of all or substantially all of the
Company’s assets (including, for the avoidance of doubt, the sale of all or substantially all of the assets of the Company’s Subsidiaries in the aggregate) or (iii) the consummation of a purchase, tender or exchange offer made to and
accepted by the holders of more than the 50% of the outstanding Shares. 
  

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 (6) Limitations on Conversion. 
 (a) Permitted Conversions. The right of the Holder to convert this Note as set forth in Section 3 is subject to the following
limitations (collectively, the “Holder Conversion Limitations”): (i) the Holder shall not have the right to convert this Note pursuant to Section 3, other than at the Fixed Conversion Price, at any time prior to the
five-month anniversary of the Issuance Date, and (ii) on or after the five-month anniversary of the Issuance Date, the Holder shall not have the right to convert, other than at the Fixed Conversion Price, during any calendar month an amount of
Principal in excess of ten percent (10%) of the Original Principal Amount (and the Interest Amount relating thereto). Notwithstanding the first sentence of this Section 6(a), the Holder Conversion Limitations shall not apply to conversions
of this Note by the Holder (A) at any time in connection with an Interest Conversion pursuant to Section 6 (and each such conversion of this Note shall be excluded for purposes of determining compliance with the Holder Conversion
Limitation set forth in clause (ii) of the first sentence of this Section 6(a)), (B) at any time after delivery by the Company of a Company Conversion Notice pursuant to Section 9, (C) on and after the first date after the
Issuance Date on which (I) a Change of Control shall have been consummated or (II) there shall have been a public announcement of a pending, proposed or intended Change of Control, (D) on and the first date after the Issuance Date on which
there has occurred any Triggering Event or Event of Default (as defined in Section 12) or an event that with the passage of time or the giving of notice would constitute a Triggering Event or an Event of Default and (E) with respect to any
conversion of this Note at the Fixed Conversion Price then in effect (and each conversion of this Note at the Fixed Conversion Price then in effect shall be excluded for purposes of determining compliance with the Holder Conversion Limitation set
forth in clause (ii) of the first sentence of this Section 6(a)). 
 (b) 4.99% Limitation. The Company shall
not effect any conversion of this Note and the Holder shall not have the right to convert Principal or any Interest Amount in excess of that portion of the Principal Amount or any Interest Amount that, upon giving effect to such conversion, would
cause the aggregate number of Shares beneficially owned by the Holder and its affiliates to exceed 4.99% of the total outstanding Shares following such conversion or issuance of Interest Shares. For purposes of the foregoing proviso, the aggregate
number of Shares beneficially owned by the Holder and its affiliates shall include the Shares issuable upon conversion of this Note, with respect to which the determination of such proviso is being made, but shall exclude the Shares that would be
issuable upon (i) conversion of the remaining, unconverted Principal and any Interest Amount with respect thereto beneficially owned by the Holder and its affiliates and (ii) exercise, conversion or exchange of the unexercised, unconverted
or unexchanged portion of any other securities of the Company (including any warrants or convertible preferred stock) subject to a limitation on conversion, exercise or exchange analogous to the limitation contained herein beneficially owned by the
Holder and its affiliates. Except as set forth in the preceding sentence, for purposes of this Section 6, beneficial ownership shall be calculated in accordance with Section 13(d) of the Securities Exchange Act of 1934, as amended (the
“1934 Act”). For purposes of this Section 6(b), in determining the number of outstanding Shares the Holder may rely on the number of outstanding Shares as reflected in (1) the Company’s most recent quarterly report on
Form 10-Q, or annual report on Form 10-K, as the case may be, (2) a more recent public announcement by the Company or (3) any other notice by the Company or the transfer agent for the common stock 

  

 21 

 
setting forth the number of Shares outstanding. Upon the written request of the Holder, the Company shall promptly, but in no event later than three
(3) Business Days following the receipt of such request, confirm in writing to the Holder the number of Shares then outstanding. In any case, the number of outstanding Shares shall be determined after giving effect to the conversion, exercise
or exchange of securities of the Company, including the Notes, the Initial Warrants and the Repurchase Warrants, if any, by the Holder and its affiliates since the date as of which such number of outstanding Shares was reported. For purposes of
determining the maximum number of Shares that the Company may issue to the Holder pursuant to Section 6(b) upon conversion of this Note on a particular Conversion Date, the Holder’s delivery of a Conversion Notice with respect to such
conversion shall constitute a representation (on which the Company may rely without investigation) by the Holder that, upon the issuance of the Shares to be issued to it on such Conversion Date, the shares of Common Stock beneficially
owned by the Holder and its affiliates shall not exceed 4.99% of the total outstanding Shares immediately after giving effect to such conversion, as determined in accordance with this Section 6(b). 
 (c) Limitation on Number of Shares Issuable Hereunder. The Company shall not be obligated to issue any Shares upon conversion of
this Note if the issuance of such Shares would exceed that number of Shares which the Company may issue upon conversion of the Notes and upon exercise of the Initial Warrants and the Repurchase Warrants, if any (the “Exchange Cap”)
without breaching the Company’s obligations under the rules or regulations of the Principal Market, if at the time of any determination the Common Stock is listed on a national securities exchange or on the NASDAQ National Market (or successor
thereto) or the NASDAQ Capital Market, except that such limitation shall not apply in the event that the Company (a) obtains Stockholder Approval, or (b) obtains a written opinion from outside counsel to the Company that such approval is
not required, which opinion shall be reasonably satisfactory to the Holders representing at least two-thirds (2/3) of the aggregate principal amount of the Notes then outstanding. Until such Stockholder Approval or written opinion is obtained,
no purchaser of Notes pursuant to the Securities Purchase Agreement (the “Purchasers”) shall be issued, at any time, upon conversion of this Note, a number of Shares greater than the difference of (i) the product of
(A) the Exchange Cap, multiplied by (B) the Allocation Percentage of such Purchaser (the “Cap Allocation Amount”), minus (ii) the aggregate number of (x) Conversion Shares that have been issued to such purchaser
prior to such time upon conversion of any Notes on or prior to the date of such determination, and (y) Warrant Shares that have been issued to such purchaser prior to such time upon exercise of any Initial Warrants or Repurchase Warrants, if
any. In the event that any Purchaser shall sell or otherwise transfer any of such Purchaser’s Notes, the transferee shall be allocated a pro rata portion of such Purchaser’s Cap Allocation Amount. In the event that any holder of Notes
shall convert all of such holder’s Notes and exercise all of such holder’s Initial Warrants and Repurchase Warrants, if any, into a number of Shares in an amount which, in the aggregate, is less than such holder’s Cap Allocation
Amount, then the difference between such holder’s Cap Allocation Amount and the number of Shares actually issued to such holder upon conversion of such holder’s Notes and exercise of such holder’s Initial Warrants and Repurchase
Warrants, if any, shall be allocated to the respective Cap Allocation Amounts of the remaining holders of Notes and Initial Warrants and Repurchase Warrants, if any, on a pro rata basis in proportion to the aggregate number of Shares issuable upon
conversion of the Notes (at the then prevailing Conversion Price) and exercise of the Initial Warrants and Repurchase Warrants (at the then prevailing exercise prices), 

  

 22 

 
if any, then held by each such Holder, without regard to any limitations on conversion or exercise. 
 (7) Interest. Interest shall be payable by the Company on each Interest Payment Date and at the Maturity Date, to the record holder
of this Note on such Interest Payment Date, in cash or, as permitted by the provisions of Section 9, by electing to convert such Interest by giving a Company Conversion Notice (as defined below) at least five (5) Business Days prior to
such Interest Payment Date (each an “Interest Conversion Election”) for a Company Conversion with respect to an Interest Amount equal to the entire amount of such Interest (the “Interest Conversion Amount”) in
accordance with, and subject to the conditions and requirements of, Section 9 (an “Interest Conversion”). If the Company does not make an Interest Conversion Election with respect to such Interest, such Interest shall be paid
in cash. The Company may only make an Interest Conversion Election if it makes the same election with respect to all of the other Notes. An Interest Conversion Election shall be irrevocable by the Company. The Company may not elect an Interest
Conversion with respect to Interest payable on the Maturity Date or on any Interest Payment Date occurring less than thirty-one (31) Trading Days prior to the Maturity Date. Upon delivery of a Company Conversion Notice with respect to an
Interest Conversion Amount, the Company shall comply with the provisions of Section 8. Any accrued and unpaid Interest which is not paid within five (5) Business Days of such accrued and unpaid Interest’s Interest Payment Date shall
bear interest at a rate equal to the lesser of 2.0% per month (prorated for partial months) or the highest lawful rate per annum from such Interest Payment Date until the same is paid in full (the “Default Interest”). The
Company shall pay any and all taxes (excluding income taxes, franchise taxes or other taxes levied on gross earnings, profits or the like of the Holder) that may be payable with respect to the issuance and delivery of Interest Shares. 
 (8) Company Alternative Redemption. 
 (a) General. At any time after the Issuance Date, the Company shall have the right to redeem some or all of the Principal (a “Company Alternative Redemption”) (excluding Principal that is part
of a Pro Rata Conversion Amount relating to a Company Conversion Notice Date occurring prior to the Company Alternative Redemption Notice Date) by (A) payment to the Holder of an amount in cash equal to the sum of (i) the outstanding
Principal being redeemed pursuant to this Section 8 and (ii) the Interest Amount with respect to such Principal as of the Company Alternative Redemption Date (as defined below) (the “Company Alternative Redemption Price”),
and (B) issuance to the Holder of warrants (the “Repurchase Warrants”) to purchase a number of Shares equal to the quotient of (1) the Principal being redeemed pursuant to the Company Alternative Redemption plus the
Interest Amount with respect to such Principal as of the Company Alternative Redemption Date, divided by (2) the arithmetic average of the Weighted Average Price of the Common Stock on each of the ten (10) consecutive Trading Days
immediately preceding the Company Alternative Redemption Date (such arithmetic average, the “Repurchase Warrant Exercise Price”); provided that the Conditions to Company Alternative Redemption (as set forth in Section 8(c)) and
the conditions of this Section 8(a) and Section 8(b) are satisfied (or waived in writing by the Holder). The Repurchase Warrants shall be in the form of Exhibit C to the Securities Purchase Agreement and shall have an initial exercise
price as of the Company Alternative Redemption Date equal to the Repurchase Warrant Exercise Price, subject to adjustment as provided therein, 

  

 23 

 
and shall have an Expiration Date (as defined in the Repurchase Warrants) of March 20, 2009. The Company may exercise its right to Company Alternative
Redemption by delivering to the Holder written notice (the “Company Alternative Redemption Notice”) at least eleven (11) Trading Days prior to the date of consummation of such redemption (“Company Alternative Redemption
Date”). The date on which the Holder receives the Company Alternative Redemption Notice is referred to as the “Company Alternative Redemption Notice Date.” A Company Alternative Redemption Notice shall be irrevocable by the
Company. If the Company elects a Company Alternative Redemption pursuant to this Section 8(a), then it must simultaneously take the same action with respect to all of the Other Notes. If the Company elects a Company Alternative Redemption (and
similar action under the Other Notes) with respect to less than all of the aggregate principal amount of Notes then outstanding, then the Company shall elect to redeem a principal amount (together with the related Interest Amount) from each of the
holders of Notes equal to the product of (I) the aggregate principal amount of the Notes that the Company has elected to redeem pursuant to this Section 8 (or the similar provisions of such Other Notes), multiplied by (II) the
Holder’s Allocation Percentage (such amount with respect to each holder of the Notes is referred to as its “Pro Rata Redemption Amount” and with respect to the Holder is referred to as the Pro Rata Redemption Amount). In the
event that the initial holder of any Notes shall sell or otherwise transfer any of such holder’s Notes, the transferee shall be allocated a pro rata portion of such holder’s Allocation Percentage. The Company Alternative Redemption Notice
shall state (i) the date selected by the Company for the Company Alternative Redemption Date in accordance with this Section 8(a), (ii) the aggregate principal amount of Notes that the Company has elected to redeem from all of the
holders of Notes pursuant to this Section 8, and (iii) each holder’s Pro Rata Redemption Amount of the principal amount of Notes the Company has elected to redeem pursuant to this Section 8(a). 
 (b) Mechanics of Company Alternative Redemption. If the Company has exercised its right to Company Alternative Redemption in
accordance with Section 8(a) and the conditions of this Section 8 are satisfied on the Company Alternative Redemption Date (including the Conditions to Company Alternative Redemption as set forth in Section 8(c)) (or waived in writing
by the Holder), then the Holder’s Pro Rata Redemption Amount, if any, that remains outstanding on the Company Alternative Redemption Date shall be redeemed by the Company on such Company Alternative Redemption Date by (A) the payment by
the Company to the Holder on such Company Alternative Redemption Date, by wire transfer of immediately available funds, of an amount equal to the Company Alternative Redemption Price for the Holder’s Pro Rata Redemption Amount, and
(B) issuance to the Holder on the Company Alternative Redemption Date of the Repurchase Warrants. Notwithstanding anything contained herein to the contrary, if the Holder delivers a Conversion Notice after a Company Alternative Redemption
Notice Date, but prior to the Company Alternative Redemption Date, then the Conversion Amount specified in such Conversion Notice shall be deducted first, from the Pro Rata Redemption Amount, and then from the remaining Principal of this Note,
unless otherwise indicated by the holder in such Conversion Notice. In the event that all of the Pro Rata Redemption Amount is converted prior to the Company Alternative Redemption Date, then the Company Alternative Redemption Notice shall be of no
further effect. Notwithstanding anything contained herein to the contrary, no notice delivered by the Company to any Holder regarding a Condition to Company Alternative Redemption shall contain any material non-public information. 
  

 24 

 (c) Conditions to Company Alternative Redemption. For purposes of this
Section 8, “Conditions to Company Alternative Redemption” means the following conditions: (i) on each day during the period beginning forty-five (45) days prior to the Company Alternative Redemption Notice Date and
ending on and including the applicable Company Alternative Redemption Date, the Common Stock is listed on the OTC Bulletin Board, a national securities exchange, the NASDAQ National Market (or any successor thereto), or the NASDAQ Capital Market,
and the Common Stock has not been suspended from trading on any such market or exchange nor shall delisting or suspension by any such market or exchange have been threatened either (A) in writing by such market or exchange or (B) by
falling below the minimum listing maintenance requirements of such market or exchange; (ii) on each day during the period beginning on and including the date that is ten (10) Trading Days prior to the Company Alternative Redemption Notice
Date and ending on and including the Company Alternative Redemption Date, a Registration Statement shall be effective and available for the sale of not less than 150% of the Registrable Securities issuable upon conversion of all of the Notes and
exercise of all Warrants outstanding as of the Company Alternative Redemption Notice Date (without regard to any limitations on conversions or exercises), in accordance with the Registration Rights Agreement, and there shall not have been any Grace
Period applicable to such Registration Statement (as defined in the Registration Rights Agreement); (iii) during the period beginning on and including the Issuance Date and ending on and including the applicable Company Alternative Redemption
Date, there shall not have occurred either (x) the public announcement of a pending, proposed or intended Change of Control that has not been abandoned, terminated or consummated and publicly disclosed as such at least ten (10) Trading
Days prior to the Company Alternative Redemption Notice Date or (y) a Triggering Event or an Event of Default, or an event that with the passage of time or the giving of notice and without being cured would constitute a Triggering Event or an
Event of Default; (iv) during the period beginning on the Issuance Date and ending on and including the Company Alternative Redemption Date, the Company shall have delivered Shares upon conversion of the Notes and upon exercise of the Initial
Warrants and Repurchase Warrants, if any, on a timely basis as set forth in Section 3(c)(ii) of the Notes and Section 2(a) of each of the Initial Warrants and the Repurchase Warrants, if any; (v) on each day during the period
beginning 90 days prior to the Company Alternative Redemption Notice Date and ending on and including the applicable Company Alternative Redemption Date, the Company and its Subsidiaries otherwise shall have been in compliance with in all material
respects and shall not have breached or been in breach in any material respect of any provision or covenant of the Securities Purchase Agreement or any of the other Transaction Documents; and (vi) the Company shall have obtained all requisite
approvals of its stockholders for the issuance of the Shares to the holders of the Notes and the Warrants. 
 (d)
Remedies. In the event that the Company does not pay the Company Alternative Redemption Price in full for the Holder’s Pro Rata Redemption Amount on the Company Alternative Redemption Date and the Conditions to Company Alternative
Redemption were satisfied, or to the extent not satisfied, were waived by the Holder, then in addition to any remedy the Holder may have under this Note and the Securities Purchase Agreement (including indemnification pursuant to Section 8
thereof or at law or in equity), the Company Alternative Redemption Price payable in respect of such unredeemed Pro Rata Redemption Amount shall bear interest at a rate equal to the lesser of 2.0% per month (prorated for partial months) and the
highest lawful interest rate. 
  

 25 

 (9) Company Conversion. 
 (a) General. The Company shall have the right, in accordance with the terms and subject to the conditions of this Section 9
(and, in the case of any Interest Conversion Amount, Section 7 and provided that the Conditions to Company Conversion (as set forth below) are satisfied, to require that all or any portion of the Principal (together with the Interest Amount
with respect thereto) due to the Holder upon maturity of this Note, or any Interest payable on any Interest Payment Date, be converted at the applicable Conversion Price (a “Company Conversion”). The Company may exercise its right
to elect a Company Conversion by delivering to the Holder written notice thereof (a “Company Conversion Notice”) no more than sixty (60) Trading Days and no less than forty five (45) Trading Days prior to the Maturity
Date, or, in the case of an Interest Conversion, at least five (5) Business Days prior to the first Trading Day of the Company Conversion Period. The date on which the Holder receives the Company Conversion Notice, as applicable is referred to
as the “Company Conversion Notice Date”). If the Company elects a Company Conversion (including an Interest Conversion pursuant to Section 7), then it must simultaneously take the same action with respect to all of the Other
Notes. The Company Conversion Notice shall be irrevocable by the Company. The Company shall require conversion of a Conversion Amount from each holder of Notes equal to (x) the product of (I) the aggregate principal amount of Notes that
the Company has elected to convert pursuant to this Section 9 (or the similar provisions of such Other Notes), together with the Interest Amount thereon, multiplied by (II) such holder’s Allocation Percentage or (y) in the case of an
Interest Conversion, the Interest Conversion Amount (such Conversion Amount with respect to each such holder is referred to as its “Pro Rata Conversion Amount”). The Company Conversion Notice shall indicate (I) the number of
consecutive Trading Days during which the Holder must convert its Pro Rata Conversion Amount (the “Company Conversion Period”), which, (A) in the case of an Interest Conversion shall be the twenty (20) consecutive Trading
Days commencing on the fifth Business Day after the Company Conversion Notice Date, and (B) in the case of any other Company Conversion shall be the thirty (30) consecutive Trading Days ending on and including the Trading Day immediately
prior to the Maturity Date, (II) the date of the first day of the Company Conversion Period, (III) the last Trading Day of the Company Conversion Period, which is the last date by which the Holder must convert its Pro Rata Conversion Amount (the
“Final Company Conversion Date”), (IV) the aggregate principal amount (or Interest in the case of an Interest Conversion Election) that the Company has elected to convert from all the holders of Notes pursuant to this Section 9
(or other similar provisions in such Other Notes), and (V) each holder’s Pro Rata Conversion Amount. 
 (b)
Mechanics of Company Conversion. If the Company has exercised its right to Company Conversion in accordance with Section 9(a) and Section 7, as applicable, and the conditions of this Section 9 are satisfied (or waived in
writing by the Holder) on the Company Conversion Notice Date and at each time the Holder delivers a Conversion Notice or is deemed to have delivered a Conversion Notice with respect to any portion of the Pro Rata Conversion Amount (a
“Company Conversion Date”) (including the Conditions to Company Conversion as set forth in Section 9(c)), then, subject to Sections 6 and 9(d), the Holder shall convert the Pro Rata Conversion Amount, together with any Interest
Amount with respect thereto accruing through and including the applicable Conversion Date, in whole or in part and at such time or times as the Holder, in its sole discretion determines, during the 

  

 26 

 
Company Conversion Period; provided, however, that the Holder shall not be permitted to convert during the Company Conversion Period, any portion of the
Conversion Amount that exceeds the product of (i) the Holder’s Allocation Percentage and (ii) twenty percent (20%) of the sum of the daily dollar trading volume (as reported by Bloomberg) of the Common Stock on its Principal
Market on each of the Trading Days during the Company Conversion Period (such limitation, the “Volume Conversion Restriction Amount”). In the event any Pro Rata Conversion Amount has not been converted by the Holder prior to the
Final Company Conversion Date, then, subject to the limitations set forth in Sections 6 and 9(e), the remaining Pro Rata Conversion Amount shall be converted as of the Final Company Conversion Date, as if the Holder had delivered a Conversion Notice
pursuant to Section 3 with respect to such Pro Rata Conversion Amount on the Final Company Conversion Date but without the Holder being required to actually deliver such Conversion Notice, provided that the Conditions to Company Conversion are
satisfied (or waived in writing by the Holder) on the Final Company Conversion Date (and, for the avoidance of doubt, on each day during the Company Conversion Period). In the event that the Conditions to Company Conversion are not satisfied on the
Final Company Conversion Date (or on any other day during the Company Conversion Period), then the Company Conversion shall be null and void with respect to all or any part designated by the Holder of the unconverted Pro Rata Conversion Amount and
the Holder shall be entitled to all the rights of a holder of this Note with respect to such amount of the Pro Rata Conversion Amount and, accordingly, shall be subject to all the other provisions of this Note, , including that if such amount
remains outstanding on the Maturity Date, then the Company shall redeem the Principal represented by such amount in accordance with Section 3(c)(vii), unless such Pro Rata Conversion Amount is an Interest Conversion Amount, in which the case
Company shall be deemed to have given a Company Alternative Redemption Notice with respect to such unconverted Pro Rata Conversion Amount (and, for purposes of Section 8(a), shall be entitled to give such Company Alternative Redemption Notice),
and such amount shall be redeemed or paid by the Company within five (5) Business Days in accordance with Section 8. Notwithstanding anything contained herein to the contrary, no notice delivered by the Company to any Holder regarding a
Condition to Company Conversion shall contain any material non-public information. 
 (c) Conditions to Company
Conversion. “Conditions to Company Conversion” means the following conditions: (i) except in the case of an Interest Conversion, the aggregate principal amount of the Notes selected for conversion by the Company as
reflected in the Company Conversion Notice is at least $500,000 (or, if less, the aggregate principal amount of the Notes then outstanding); (ii) the aggregate Conversion Amount of the Notes selected for conversion by the Company as reflected
in the Company Conversion Notice shall not exceed twenty (20%) of the product of (A) the arithmetic average of the daily dollar trading volume (as reported by Bloomberg) of the Common Stock on its Principal Market over the twenty
(20) consecutive Trading Days ending on and including the date that is immediately preceding the Company Conversion Notice Date, multiplied by (B) the number of Expected Trading Days during the Company Conversion Period to which the
Company Conversion Notice relates; (iii) during the period beginning on and including the Issuance Date and ending on and including the Company Conversion Date, there shall not have occurred either (x) the public announcement of a pending,
proposed or intended Change of Control that has not been abandoned, terminated or consummated and publicly disclosed as such at least ten (10) Trading Days prior to the Company Conversion Date or (y) a Triggering Event or an Event of
Default (as 

  

 27 

 
defined in Section 12); (iv) during the period beginning on the Issuance Date and ending on and including the Company Conversion Date, the Company
shall have delivered Shares upon conversion of the Notes and upon exercise of the Initial Warrants and Repurchase Warrants, if any, on a timely basis as set forth in Section 3(c)(ii) of the Notes and Section 3(a) of the Initial Warrants
and Repurchase Warrants, if any; (v) on each day during the period beginning forty-five (45) days prior to the Company Conversion Notice Date and ending on and including the applicable Company Conversion Date, the Common Stock is listed on
the OTC Bulletin Board, a national securities exchange, the NASDAQ National Market (or any successor thereto), or the NASDAQ Capital Market, and the Common Stock has not been suspended from trading on any such market or exchange nor shall delisting
or suspension by any such market or exchange have been threatened either (A) in writing by such market or exchange or (B) by falling below the minimum listing maintenance requirements of such market or exchange; (vi) on each day
during the period beginning on and including the date that is ten (10) days prior to the Company Conversion Notice Date and ending on and including the Company Conversion Date, a Registration Statement shall be effective and available for the
sale of not less 150% of the Registrable Securities issuable upon conversion of all of the Notes and exercise of all Warrants outstanding as of the Company Conversion Notice Date (without regard to any limitations on conversions or exercises), in
accordance with the Registration Rights Agreement, and there shall not have been any Grace Period applicable to such Registration Statement (as defined in the Registration Rights Agreement); (vii) on each day during the period beginning ninety
(90) days prior to the Company Conversion Notice Date and ending on and including the applicable Company Conversion Date, the Company and its Subsidiaries otherwise shall have been in compliance with in all respects and shall not have breached
or been in breach of any provision or covenant of the Notes or any other Transaction Documents; and (viii) the Company shall have obtained all requisite approvals of its stockholders for the issuance of the Shares to the holders of the Notes
and the Warrants. 
 (d) Company Conversion Period Volume Limitations. Notwithstanding anything contained in this
Section 9 to the contrary, on the applicable Final Company Conversion Date, (i) the Holder shall not be required (but shall be permitted subject to clause (ii) of this Section 9(d)) to convert (and shall not be deemed, solely as
a result of Section 9(b), to have converted) any portion of the Pro Rata Conversion Amount on the applicable Final Company Conversion Date in excess of the difference between (A) the product of (I) the Holder’s Series Allocation
Percentage and (II) ten percent (10%) of the sum of the daily dollar trading volume (as reported by Bloomberg) of the Common Stock on its Principal Market on each of the Trading Days during the Company Conversion Period, minus (B) any Pro
Rata Conversion Amount converted by the Holder during the Company Conversion Period and (ii) the Holder shall neither be required nor permitted to convert (and shall not be deemed, solely as a result of Section 9(b) to have converted) any
portion of the Pro Rata Conversion Amount on the applicable Final Company Conversion Date in excess of the difference between (A) the applicable Volume Conversion Restriction Amount, minus (B) any Pro Rata Conversion Amount converted by
the Holder during the Company Conversion Period. Following the Final Company Conversion Date, the Company Conversion shall be null and void with respect to the unconverted Pro Rata Conversion Amount, and the Holder shall be entitled to all the
rights of a holder of this Note with respect to such amount of the Pro Rata Conversion Amount, and, accordingly, shall be subject to all the other provisions of this Note, including that if such amount remains outstanding on the Maturity Date, then
the Company shall redeem the Principal 

  

 28 

 
represented by such amount in accordance with Section 3(c)(vii), unless such Pro Rata Conversion Amount is an Interest Conversion Amount, in which case
the Company shall be deemed to have given a Company Alternative Redemption Notice with respect to such unconverted Pro Rata Conversion Amount (and, for purposes of Section 8(a), shall be entitled to give such Company Alternative Redemption
Notice), and such amount shall be redeemed or paid by the Company within five (5) Business Days in accordance with Section 8. 
 (10) Reservation of Shares. 
 (a) Reservation. The Company shall, so long as
any of the Notes are outstanding, take all action necessary to reserve and keep available out of its authorized and unissued Common Stock, solely for the purpose of effecting the conversion of the Notes, such number of Shares as shall from time to
time be sufficient to effect the conversion of all of the principal amount then outstanding under the Notes (together with accrued and unpaid Interest thereon); provided that the number of Shares so reserved shall at no time be less than 150% of the
number of Shares for which the Notes are at any time convertible (without regard to any limitations on conversions) (the “Required Reserve Amount”). The initial number of Shares reserved for conversions of the Notes and each
increase in the number of Shares so reserved shall be allocated pro rata among the holders of the Notes based on the principal amount of the Notes held by each holder at the time of issuance of the Notes or increase in the number of reserved Shares,
as the case may be. In the event the Holder shall sell or otherwise transfer any portion of the Holder’s Notes, each transferee shall be allocated a pro rata portion of the number of Shares reserved for such transferor. Any Shares reserved and
allocated to any Person that ceases to hold any Notes shall be allocated to the remaining holders of the Notes, pro rata based on the principal amount of the Notes then held by such holders. 
 (b) Insufficient Authorized Shares. If at any time while any of the Notes remain outstanding the Company does not have a sufficient
number of authorized and unreserved Shares to satisfy its obligation to reserve for issuance upon conversion of the Notes at least a number of Shares equal to the Required Reserve Amount, then the Company shall immediately take all action necessary
to increase the Company’s authorized Shares to an amount sufficient to allow the Company to reserve the Required Reserve Amount for the Notes then outstanding. 
 (11) Voting Rights. The Holders of the Notes shall have no voting rights, except as required by law and as expressly provided in
this Note. 
 (12) Defaults and Remedies. 
 (a) Events of Default. An “Event of Default” is (i) default in payment of any Principal of this Note, any
Redemption Price, any Company Alternative Redemption Price or any Change of Control Redemption Price, when and as due; (ii) default in payment of any Interest on this Note that is not included in an amount described in the immediately preceding
clause (i) that is not cured within two (2) Business Days from the date such Interest was due; (iii) failure by the Company for ten (10) days after notice to it to comply with any other provision of this Note in all material
respects; (iv) any default in payment of at least $100,000, individually or in the aggregate, under or acceleration prior to maturity of, or any 

  

 29 

 
event or circumstances arising such that, any person is entitled, or could, with the giving of notice and/or lapse of time and/or the fulfillment of any
condition and/or the making of any determination, become entitled, to require repayment before its stated maturity of, or to take any step to enforce any security for, any mortgage, indenture or instrument under which there may be issued or by which
there may be secured or evidenced any indebtedness for money borrowed of at least $100,000 by the Company or any of its Majority-Owned Subsidiaries or for money borrowed the repayment of at least $100,000 of which is guaranteed by the Company or any
of its Majority-Owned Subsidiaries, whether such indebtedness or guarantee now exists or shall be created hereafter; (v) if the Company or any of its Majority-Owned Subsidiaries pursuant to or within the meaning of any Bankruptcy Law (as
defined below); (A) commences a voluntary case; (B) consents to the entry of an order for relief against it in an involuntary case; (C) consents to the appointment of a Custodian of it or any of its Majority-Owned Subsidiaries for all
or substantially all of its property; (D) makes a general assignment for the benefit of its creditors; or (E) admits in writing that it is generally unable to pay its debts as the same become due; (vi) an involuntary case or other
proceeding is commenced directly against the Company or any of its Majority-Owned Subsidiaries seeking liquidation, reorganization or other relief with respect to it or its Indebtedness under any Bankruptcy Law now or hereafter in effect or seeking
the appointment of a trustee, receiver, liquidator, custodian or other similar official of it or any substantial part of its property, and such involuntary case or other Bankruptcy Law proceeding remains undismissed and unstayed for a period of
thirty (30) days, or an order of relief is entered against the Company or any of its Subsidiaries as debtor under the Bankruptcy Laws as are now or hereafter in effect; (vii) the Company fails to file, or is determined to have failed to
file, in a timely manner any report required to be filed with the SEC pursuant to the 1934 Act, provided that any filing made within the time period permitted by Rule 12b-25 under the 1934 Act and pursuant to a timely filed Form 12b-25 shall, for
purposes of this clause (vii), be deemed to be timely filed; provided, however, that a failure to file in a timely manner a report that is required solely pursuant to Item 1.01, 1.02, 2.03, 2.04, 2.05, 2.06 or 4.02(a) of SEC Form 8-K shall
not be deemed an Event of Default pursuant to this clause (vii); (viii) the Company or any of its Subsidiaries breaches any representation, warranty, covenant or other term or condition of the Security Documents that adversely affects the
security interest of the Holder (or any agent or representative thereof on their behalf) in any material portion of the Collateral (as defined in the Security Agreement) or the perfection or priority thereof; or (ix) one or more judgments,
non-interlocutory orders or decrees shall be entered by a U.S. state or federal or a foreign court or administrative agency of competent jurisdiction against any the Company or any of its Subsidiaries involving in the aggregate a liability (to the
extent not covered by independent third-party insurance) as to any single or related series of transactions, incidents or conditions, of $100,000 or more, and the same shall remain unsatisfied, unvacated, unbonded or unstayed pending appeal for a
period of thirty (30) days after the entry thereof. The term “Bankruptcy Law” means Title 11, U.S. Code, or any similar federal or state law for the relief of debtors. The term “Custodian” means any receiver,
trustee, assignee, liquidator or similar official under any Bankruptcy Law. Within five (5) Business Days after the occurrence of any Event of Default set forth in clause (iv), (v), (vi), (viii) or (ix) above, the Company shall
deliver written notice thereof to the Holder. 
 (b) Remedies. If an Event of Default occurs and is continuing, the
Holder of this Note may declare all of this Note, including all amounts due hereunder (the “Acceleration Amount”), to be due and payable immediately, except that in the case of an 

  

 30 

 
Event of Default arising from events described in clauses (v) and (vi) of Section 12(a), this Note shall immediately become due and payable
without further action or notice. In addition to any remedy the Holder may have under this Note and the Securities Purchase Agreement, such unpaid amount shall bear interest at a rate equal to the lesser of 2.0% per month (prorated for partial
months) or the highest lawful interest rate until paid in full. Nothing in this Section 12 shall limit any other rights the Holder may have under this Note, the Security Documents or the Securities Purchase Agreement, including Sections 3 and 4
of this Note. 
 (c) Void Acceleration. In the event that the Company does not pay the Acceleration Amount within five
(5) Business Days of this Note becoming due under Section 12(b), at any time thereafter and until the Company pays such unpaid Acceleration Amount in full, the Holder shall have the option to, in lieu of redemption, require the Company to
promptly return this Note (to the extent this Note has been previously delivered to the Company), in whole or any portion thereof, to the Holder, by sending written notice thereof to the Company via facsimile (the “Void Acceleration
Notice”). Upon the Company’s receipt of such Void Acceleration Notice, (i) the acceleration pursuant to Section 12(b) shall be null and void with respect to the portion of this Note subject to such Void Acceleration Notice,
(ii) the Company shall promptly return the portion of this Note (to the extent this Note has been previously delivered to the Company) subject to such Void Acceleration Notice, and (iii) the Fixed Conversion Price with respect to all of
the Principal shall be adjusted to the lesser of (A) the Fixed Conversion Price as in effect on the date on which the Void Acceleration Notice is delivered to the Company and (B) the lowest Weighted Average Price of the Common Stock during
the period beginning on and including the date on which this Note became due under Section 12(b) and ending on and including the date on which the Void Acceleration Notice is delivered to the Company. 
 (13) Other Indebtedness. Payments of principal and other payments due under this Note shall not be subordinated to any obligations
of the Company. The Holder of this Note is entitled to the benefits of the Security Documents, and in the event of a transfer of this Note in accordance with the terms hereof and the Securities Purchase Agreement, the Holder shall be deemed to have
assigned its rights under the Security Documents. For so long as this Note is outstanding, the Company shall not, shall cause each of its Majority-Owned Subsidiaries not to, and shall not authorize any of its Minority-Owned Subsidiaries to,
(a) issue, incur, assume, maintain, suffer to exist or extend the term of any Indebtedness (as defined below) except for (I) Indebtedness under the Notes, (II) Indebtedness, (A) the holders of which agree in writing to be subordinate
to the Notes on terms and conditions acceptable to the Buyers, including with regard to interest payments and repayment of principal, (B) which does not mature or otherwise require or permit redemption or repayment prior to or on the Maturity
Date of any Notes then outstanding; and (C) which is not secured by any assets of the Company or any of its Subsidiaries, (III) Indebtedness solely between the Company and/or one of its domestic Subsidiaries, on the one hand, and the Company
and/or one of its domestic Subsidiaries, on the other, provided that in each case a majority of the equity of any such domestic Subsidiary is directly or indirectly owned by the Company, such domestic Subsidiary is controlled by the Company and such
domestic Subsidiary is a party to the Guaranty Agreement and the Security Agreement, (IV) Indebtedness to contract research organizations, hospitals or similar entities or organizations incurred in the ordinary course of business in connection with
FDA approval related trials of the Company’s products (“Product Trial Payables”) not unpaid in excess of 30 

  

 31 

 
days from the receipt of invoice and not exceeding at any one time an aggregate of $5,000,000, (V) Indebtedness under that certain Guaranty of Sublease,
dated August 24, 2004, made by the Company in favor of The Regents of the University of California with respect to the obligations of Phage under that certain Sublease Agreement, dated August 24, 2004, between Phage and The Regents of the
University of California, as such Guaranty of Sublease and Sublease Agreement are in effect on the date of the Securities Purchase Agreement, without amendment, modification, supplement or other revision thereto, or (VI) Indebtedness under that
certain Standard Lease Guaranty, dated March, 2006, made by the Company in favor of Canta Rana Ranch, L.P. with respect to the obligations of Phage under that certain Standard Industrial Net Lease, dated March, 2006, by and between Phage and Canta
Rana Ranch, L.P., as such Standard Lease Guaranty and Standard Industrial Net Lease are in effect on the date of the Securities Purchase Agreement, without amendment, modification, supplement or other revision thereto; (b) issue, incur, assume,
maintain, suffer to exist or extend the term of any Indebtedness in a principal amount in excess of $100,000 where the proceeds of such Indebtedness are to be used to develop, or in connection with the development of, assets in which the holders of
the Notes do not have a valid, perfected first priority security interest; (c) issue any capital stock of the Company or any Subsidiary redeemable prior to the Maturity Date; (d) directly or indirectly, create, assume or suffer to exist
any Lien, other than a Permitted Lien, on any asset now owned or hereafter acquired by the Company or any of its Subsidiaries; or (e) redeem, or otherwise repay in cash any principal of, any Indebtedness (other than Indebtedness under the Notes
and Indebtedness permitted by clauses (IV), (V) and (VI) of clause (a) above)). For purposes of this Note: (x) “Indebtedness” of any Person means, without duplication (A) all indebtedness for borrowed money,
(B) all obligations issued, undertaken or assumed as the deferred purchase price of property or services (other than unsecured account trade payables (excluding Product Trial Payables) that are (i) entered into or incurred in the ordinary
course of the Company’s and its Subsidiaries’ business, (ii) on terms that require full payment within 90 days, (iii) not unpaid in excess of 60 days from the receipt of invoice or are being contested in good faith and as to
which such reserve as is required by GAAP has been made and (iv) not exceeding at any one time an aggregate among the Company and its Majority-Owned Subsidiaries of $2,000,000 (excluding any accrued interest on the Notes)), (C) all
reimbursement or payment obligations with respect to letters of credit, surety bonds and other similar instruments, (D) all obligations evidenced by notes, bonds, debentures, redeemable capital stock or similar instruments, including
obligations so evidenced incurred in connection with the acquisition of property, assets or businesses, (E) all indebtedness created or arising under any conditional sale or other title retention agreement, or incurred as financing, in either
case with respect to any property or assets acquired with the proceeds of such indebtedness (even though the rights and remedies of the seller or bank under such agreement in the event of default are limited to repossession or sale of such
property), (F) all Capital Lease Obligations, (G) all indebtedness referred to in clauses (A) through (F) above secured by (or for which the holder of such Indebtedness has an existing right, contingent or otherwise, to be
secured by) any mortgage, Lien, pledge, change, security interest or other encumbrance upon or in any property or assets (including accounts and contract rights) owned by any Person, even though the Person that owns such assets or property has not
assumed or become liable for the payment of such indebtedness, and (H) all Contingent Obligations in respect of indebtedness or obligations of others of the kinds referred to in clauses (A) through (G) above; (y) “Capital
Lease Obligation” means, as to any Person, any obligation that is required to be classified and accounted for as a capital lease on a balance sheet of such Person 

  

 32 

 
prepared in accordance with GAAP, and the amount of such obligation shall be the capitalized amount thereof, determined in accordance with GAAP; and
(z) “Contingent Obligation” means, as to any Person, any direct or indirect liability, contingent or otherwise, of that Person with respect to any indebtedness, lease, dividend or other obligation of another Person if the
primary purpose or intent of the Person incurring such liability, or the primary effect thereof, is to provide assurance to the obligee of such liability that such liability will be paid or discharged, or that any agreements relating thereto will be
complied with, or that the holders of such liability will be protected (in whole or in part) against loss with respect thereto. For purposes of this Note, the Company shall be deemed to have authorized a Minority-Owned Subsidiary to take an action
if the Company or any of its Majority-Owned Subsidiaries causes, directs or expressly authorizes such Minority-Owned Subsidiary to take such action or fails to (A) vote its equity interest against the taking of such action (if a vote of equity
holders is taken with respect to such action), or (B) cause any directors, managers or similar officials appointed by it to vote against the taking of such action (if a vote of directors, managers or similar officials is taken with respect to
such action). 
 (14) Participation; Restrictions. While this Note is outstanding, the Company shall not, shall cause
each of its Majority-Owned Subsidiaries not to, and shall not authorize any of its Minority-Owned Subsidiaries to: (i) declare, set aside or pay any dividends on or make any other distributions (whether in cash, stock, equity securities or
property) in respect of any capital stock or split, combine or reclassify any capital stock or issue or authorize the issuance of any other securities in respect of, in lieu of or in substitution for any capital stock; provided however, that any
Subsidiary may declare, set aside or pay any dividends on or make any other distributions (whether in cash, stock, equity securities or property) in respect of any of its capital stock that is held solely by the Company or by a domestic Subsidiary,
provided that a majority of the equity of such domestic Subsidiary is directly or indirectly owned by the Company, such domestic Subsidiary is controlled by the Company and such domestic Subsidiary is a party to the Guaranty Agreement and the
Security Agreement, (ii) purchase, redeem or otherwise acquire, directly or indirectly, any shares of its capital stock or the capital stock of any of its Subsidiaries, direct or indirect, except repurchases of unvested shares at cost in
connection with the termination of the employment relationship with any employee pursuant to stock option or purchase agreements in effect on the date hereof and set forth on Schedule 3(c) of the Securities Purchase Agreement, or
(iii) grant, issue or sell any Options, Convertible Securities or rights to purchase stock, warrants, securities or other property pro rata to the record holders of any class of its capital stock. While this Note is outstanding, the Company and
its Subsidiaries shall not enter into any agreement which would limit or restrict the Company’s or any of its Subsidiaries’ ability to perform under, or take any other voluntary action to avoid or seek to avoid the observance or
performance of any of the terms to be observed or performed by it under, this Note, the Securities Purchase Agreement, the Security Documents or any of the other Transaction Documents. 
 (15) Notices. The Company will give written notice to the Holder at least ten (10) Business Days prior to the date on which
the Company closes its books or takes a record (I) with respect to any dividend or distribution upon the Common Stock, (II) with respect to any pro rata subscription offer to holders of Common Stock or (III) for determining rights to vote with
respect to any Organic Change, dissolution or liquidation, provided that such information shall be made known to the public prior to or in conjunction with such notice being provided to the 

  

 33 

 
Holder. The Company will also give written notice to the Holder at least ten (10) Business Days prior to the date on which any Organic Change,
dissolution or liquidation will take place, provided that such information shall be made known to the public prior to or in conjunction with such notice being provided to the Holder. 
 (16) Vote to Change the Terms of the Notes. The written consent of the Company and the holders representing at least two-thirds
(2/3) of the principal amount then outstanding under all of the Notes shall be required for any change in the Notes (including this Note), and upon receipt of such consent, each Note shall be deemed amended thereby. 
 (17) Lost or Stolen Notes. Upon receipt by the Company of evidence reasonably satisfactory to the Company of the loss, theft,
destruction or mutilation of this Note, and, in the case of loss, theft or destruction, of an indemnification undertaking by the Holder to the Company in customary form and reasonably satisfactory to the Company and, in the case of mutilation, upon
surrender and cancellation of this Note, the Company shall execute and deliver a new Note of like tenor and date; provided, however, the Company shall not be obligated to re-issue a Note if the Holder contemporaneously requests the Company to
convert this Note in its entirety into Shares as permitted hereunder. 
 (18) Remedies, Characterizations, Other
Obligations, Breaches and Injunctive Relief. The remedies provided in this Note shall be cumulative and in addition to all other remedies available under this Note, at law or in equity (including a decree of specific performance and/or other
injunctive relief), no remedy contained herein shall be deemed a waiver of compliance with the provisions giving rise to such remedy, and nothing herein shall limit the Holder’s right to pursue actual damages for any failure by the Company to
comply with the terms of this Note. The Company covenants to the Holder that there shall be no characterization concerning this instrument other than as expressly provided herein. Amounts set forth or provided for herein with respect to payments,
conversion and the like (and the computation thereof) shall be the amounts to be received by the Holder thereof and shall not, except as expressly provided herein, be subject to any other obligation of the Company (or the performance thereof). The
Company acknowledges that a breach by it of its obligations hereunder will cause irreparable harm to the Holder and that the remedy at law for any such breach may be inadequate. The Company therefore agrees that, in the event of any such breach or
threatened breach, the Holder shall be entitled, in addition to all other available remedies, to an injunction restraining any breach, without the necessity of showing economic loss and without any bond or other security being required. 

(19) Specific Shall Not Limit General; Construction. No specific provision contained in this Note shall limit or modify any more
general provision contained herein. This Note shall be deemed to be jointly drafted by the Company and all buyers of Notes pursuant to the Securities Purchase Agreement and shall not be construed against any person as the drafter hereof. 

(20) Failure or Indulgence Not Waiver. No failure or delay on the part of the Holder in the exercise of any power, right or
privilege hereunder shall operate as a waiver thereof, nor shall any single or partial exercise of any such power, right or privilege preclude other or further exercise thereof or of any other right, power or privilege. 
  

 34 

 (21) Notice. Whenever notice is required to be given under this Note, unless
otherwise provided herein, such notice shall be given in accordance with Section 9(f) of the Securities Purchase Agreement. 
 (22) Transfer of this Note. The Holder may assign or transfer some or all of its rights hereunder, subject to compliance with the 1933 Act and the provisions of Section 2(f) of the Securities Purchase Agreement without the
consent of the Company; provided, however, that any such assignment or transfer shall be void and of no force and effect unless the assignee or transferee hereof executes a joinder to the Security Agreement. The Holder covenants that it will cause
any such assignee or transferee to execute such joinder. Notwithstanding anything to the contrary contained in this Section 22, each such assignee or transferee, upon becoming a Holder hereunder, acknowledges that it is bound by the terms and
conditions of Section 5.12 of the Security Agreement, whether or not it has executed such joinder. Holder shall require each such assignee or transferee to acknowledge that such assignee or transferee shall be bound by the provisions of
Section 4(r) of the Securities Purchase Agreement. 
 (23) Payment of Collection, Enforcement and Other Costs. If
(a) this Note is placed in the hands of an attorney for collection or enforcement or is collected or enforced through any legal proceeding; or (b) an attorney is retained to represent the Holder in any bankruptcy, reorganization,
receivership of the Company or other proceedings affecting Company creditors’ rights and involving a claim under this Note, then the Company shall pay the costs incurred by the Holder for such collection, enforcement or action, including
reasonable attorneys’ fees and disbursements. 
 (24) Cancellation. After all principal and other amounts at any
time owed under this Note have been paid in full or converted into Shares in accordance with the terms hereof, this Note shall automatically be deemed canceled, shall be surrendered to the Company for cancellation and shall not be reissued.

 (25) Note Exchangeable for Different Denominations. Subject to Section 3(c)(viii), in the event of a conversion
or redemption pursuant to this Note of less than all of the Principal, the Company shall promptly cause to be issued and delivered to the Holder, upon tender by the Holder of this Note, a new Note of like tenor representing the remaining Principal
that has not been so converted or redeemed. This Note is exchangeable, upon the surrender hereof by the Holder at the principal office of the Company, for a new Note or Notes containing the same terms and conditions and representing in the aggregate
the Principal, and each such new Note will represent such portion of such Principal as is designated by the Holder at the time of such surrender. The date the Company issued this Note shall be the “Issuance Date” hereof regardless of the
number of times a new Note shall be issued. 
 (26) Taxes. 
 (a) Payments Free of Taxes. Any and all payments by or on account of any obligation of the Company or any of its Subsidiaries under
the Notes, the Securities Purchase Agreement or any other Transaction Document shall be made without any set-off, counterclaim or deduction and free and clear of and without deduction for any Indemnified Taxes; provided that if the Company or any of
its Subsidiaries shall be required to deduct any 

  

 35 

 
Indemnified Taxes from such payments, then (i) the sum payable shall be increased as necessary so that after making all required deductions (including
deductions applicable to additional sums payable under this Section 26(a)), the Holder receives an amount equal to the sum it would have received had no such deductions been made, (ii) the Company or such Subsidiary, as applicable, shall
make such deductions and (iii) the Company or such Subsidiary shall pay the full amount deducted to the relevant Governmental Authority in accordance with applicable law; provided, further, that if the Company or any of its Subsidiaries is
required to make an additional payment to the Holder under this Section 26(a), and if the Holder is entitled to a cash refund or credit against cash taxes payable which is both identifiable and quantifiable by the Holder as being attributable
to the imposition of such Indemnified Taxes (a “Tax Refund”), and such Tax Refund may be obtained without increased liability or obligation to the Holder (including any obligation of the Holder to file tax returns in jurisdictions
where it would not otherwise be obligated to file tax returns), then, upon the written request of the Company, the Holder shall apply for such Tax Refund and, to the extent such Tax Refund is received by the Holder, shall reimburse the Company or
such Subsidiary for such amount as the Holder shall determine to be the proportion of the Tax Refund attributable to such additional payment as will leave the Holder after the reimbursement in the same position as it would have been if the
additional payment had not been required; provided that, if any Tax Refund reimbursed by the Holder to the Company or such Subsidiary is subsequently disallowed, the Company shall repay the Holder such amount (together with interest and any
applicable penalty payable to the Holder to the relevant taxing authority) promptly after the Holder notifies the Company of such disallowance. The Company agrees to reimburse the Holder for the Holder’s reasonable out-of-pocket expenses, if
any, incurred in complying with any request hereunder and agrees that all costs incurred by the Holder in respect of this Section 26(a) may be deducted from the amount of any reimbursement to the Company or any of its Subsidiaries in respect of
any Tax Refund pursuant to this Section 26(a). 
 (b) Indemnification by the Company. The Company shall indemnify
the Holder, within ten (10) days after written demand therefor, for the full amount of any Indemnified Taxes paid by the Holder, on or with respect to any payment by or on account of any obligation of the Company or any of its Subsidiaries
under the Notes, the Securities Purchase Agreement and the other Transaction Documents (including Indemnified Taxes imposed or asserted on or attributable to amounts payable under this Section 26) and any penalties, interest and reasonable
expenses arising therefrom or with respect thereto, whether or not such Indemnified Taxes were correctly or legally imposed or asserted by the relevant Governmental Authority. A certificate of the Holder as to the amount of such payment or liability
under this Section 26 shall be delivered to the Company and shall be conclusive absent demonstrable error. 
 (27)
Waiver of Notice. To the extent permitted by law, the Company hereby waives demand, notice, protest and all other demands and notices in connection with the delivery, acceptance, performance, default or enforcement of this Note, the Security
Documents and the Securities Purchase Agreement and the other Transaction Documents. 
 (28) Governing Law. This Note
shall be construed and enforced in accordance with, and all questions concerning the construction, validity, interpretation and performance of this Note shall be governed by, the internal laws of the State of New York, without giving effect to any
choice of law or conflict of law provision or rule (whether of the State of New York or 

  

 36 

 
any other country or jurisdiction) that would cause the application of the laws of any jurisdiction or country other than the State of New York. Each party
hereby irrevocably submits to the exclusive jurisdiction of the state and federal courts sitting in the City of New York, borough of Manhattan, for the adjudication of any dispute hereunder or in connection herewith or with any transaction
contemplated hereby or discussed herein, and hereby irrevocably waives, and agrees not to assert in any suit, action or proceeding, any claim that it is not personally subject to the jurisdiction of any such court, that such suit, action or
proceeding is brought in an inconvenient forum or that the venue of such suit, action or proceeding is improper. Each party hereby irrevocably waives personal service of process and consents to process being served in any such suit, action or
proceeding by mailing a copy thereof to such party at the address for such notices to it under this Note and agrees that such service shall constitute good and sufficient service of process and notice thereof. Nothing contained herein shall be
deemed to limit in any way any right to serve process in any manner permitted by law. EACH PARTY HEREBY IRREVOCABLY WAIVES ANY RIGHT IT MAY HAVE, AND AGREES NOT TO REQUEST, A JURY TRIAL FOR THE ADJUDICATION OF ANY DISPUTE HEREUNDER OR IN CONNECTION
HEREWITH OR ARISING OUT OF THIS NOTE OR ANY TRANSACTION CONTEMPLATED HEREBY. 
 (29) Effect of Redemption or Conversion; No
Prepayment. Upon payment of the Redemption Price, the Change of Control Redemption Price or the Company Alternative Redemption Price, each in accordance with the terms hereof with respect to any portion of the Principal of this Note, or delivery
of Shares upon conversion of any portion of the Principal in accordance with the terms hereof, such portion of the Principal of this Note shall be deemed paid in full and shall no longer be deemed outstanding for any purpose. Except as specifically
set forth in this Note, including Section 3, the Company does not have any right, option, or obligation, to pay any portion of the Principal at any time prior to the Maturity Date. 
 (30) Payment Set Aside. To the extent that the Company makes a payment or payments to the Holder hereunder or the Holder enforces
or exercises its rights hereunder, and such payment or payments or the proceeds of such enforcement or exercise or any part thereof are subsequently invalidated, declared to be fraudulent or preferential, set aside, recovered from, disgorged by or
are required to be refunded, repaid or otherwise restored to the Company, by a trustee, receiver or any other person under any law (including any bankruptcy law, U.S. state or federal law, common law or equitable cause of action), then to the extent
of any such restoration the obligation or part thereof originally intended to be satisfied shall be revived and continued in full force and effect as if such payment had not been made or such enforcement or setoff had not occurred. 
  

 37 

 (31) Interpretative Matters. Unless the context otherwise requires, (a) all
references to Sections, Schedules or Exhibits are to Sections, Schedules or Exhibits contained in or attached to this Note, (b) each accounting term not otherwise defined in this Note has the meaning assigned to it in accordance with GAAP,
(c) words in the singular or plural include the singular and plural and pronouns stated in either the masculine, the feminine or neuter gender shall include the masculine, feminine and neuter and (d) the use of the word
“including” in this Note shall be by way of example rather than limitation. If a stock split, stock dividend, stock combination or other similar event occurs during any period over which an average price is being determined, then an
appropriate adjustment will be made to such average to reflect such event. 
 * * * * * * 
  

 38 

 IN WITNESS WHEREOF, the Company has caused this Note to be executed on its behalf by the
undersigned as of the 20th day of March, 2006. 
  

			
	CARDIOVASCULAR BIOTHERAPEUTICS, INC.
		
	By:	 	  
	 Name:
	 	  
	 Title:
	 	  

 EXHIBIT I 
 CARDIOVASCULAR BIOTHERAPEUTICS, INC. 
 CONVERSION NOTICE 
 Reference is made to the Senior Secured Note (the “Note”) of CARDIOVASCULAR BIOTHERAPEUTICS, INC., a Delaware corporation (the
“Company”), in the original principal amount of $                    . In accordance with and pursuant to the Note, the
undersigned hereby elects to convert the Conversion Amount (as defined in the Note) of the Note indicated below into Shares of Common Stock, par value $0.001 per share (the “Common Stock”), of the Company, as of the date specified
below. 
 Date of
Conversion:                     
 Aggregate Conversion Amount to be converted at the Fixed Conversion Price (as defined in the Note) other than pursuant to Section 9
thereof:                                      
   
 Principal, applicable thereto, to be
converted:                                      
   
 Aggregate Conversion Amount to be converted at the Conversion Price other than pursuant to Section 9
thereof:                     
 Principal, applicable thereto, to be
converted:                                      
   
 Aggregate Conversion Amount to be converted pursuant to a Company Conversion (as defined in the Note) other than in
connection with an Interest Conversion:
                                        

 Principal, applicable thereto, to be
converted:                                      
   
 Aggregate Interest Conversion Amount to be converted pursuant to a Company Conversion:
                             
 Please confirm the following information: 
 Conversion
Price:                                       
                                        
                  
 Number of shares of Common Stock
to be
issued:                                       
      
 Please issue the Common Stock into which the Note is being converted in the following name and to the following address:

 Issue
to:                                       
                                        
                              
 Facsimile
Number:                                       
                                        
              
  

							
	 Authorization:
	 	  	  	
		  	 By:
	 	  	  	
		  	 Title:
	 	  	  	

 Dated:__________________________________ 
 DTC Participant Number and Name (if electronic book entry
transfer):                                      
   
 Account Number (if electronic book entry
transfer):                                      
                               

 ACKNOWLEDGMENT 
 The Company hereby acknowledges this Conversion Notice and hereby directs [TRANSFER AGENT] to issue the above indicated number of shares of Common Stock in accordance with the Transfer Agent Instructions dated
___________ ___, 200_ from the Company and acknowledged and agreed to by [TRANSFER AGENT]. 
  

			
	CARDIOVASCULAR BIOTHERAPEUTICS, INC.
		
	By:	 	  
	 Name:
	 	  
	 Title:Form of Initial Warrant

 EXHIBIT 10.8 
 FORM OF INITIAL WARRANT 
 THE SECURITIES REPRESENTED BY THIS WARRANT HAVE NOT BEEN REGISTERED UNDER THE SECURITIES
ACT OF 1933, AS AMENDED, OR APPLICABLE STATE SECURITIES LAWS. THE SECURITIES MAY NOT BE OFFERED FOR SALE, SOLD, TRANSFERRED OR ASSIGNED (I) IN THE ABSENCE OF (A) AN EFFECTIVE REGISTRATION STATEMENT FOR THE SECURITIES UNDER THE SECURITIES
ACT OF 1933, AS AMENDED, OR APPLICABLE STATE SECURITIES LAWS OR (B) AN OPINION OF COUNSEL, IN A GENERALLY ACCEPTABLE FORM, THAT REGISTRATION IS NOT REQUIRED UNDER SAID ACT OR APPLICABLE STATE SECURITIES LAWS OR (II) UNLESS SOLD PURSUANT TO RULE
144 UNDER SAID ACT. NOTWITHSTANDING THE FOREGOING, THE SECURITIES MAY BE PLEDGED IN CONNECTION WITH A BONA FIDE MARGIN ACCOUNT OR OTHER LOAN OR FINANCING ARRANGEMENT SECURED BY THE SECURITIES. ANY TRANSFEREE OF THIS WARRANT SHOULD CAREFULLY REVIEW
THE TERMS OF THIS WARRANT, INCLUDING SECTION 2(f) HEREOF. THE SECURITIES REPRESENTED BY THIS WARRANT MAY BE LESS THAN THE NUMBER SET FORTH ON THE FACE HEREOF PURSUANT TO SECTION 2(f) HEREOF. ASSIGNEES OR TRANSFEREES OF THIS WARRANT ARE BOUND BY THE
TRADING RESTRICTIONS OF SECTION 4(r) OF THE SECURITIES PURCHASE AGREEMENT (AS DEFINED HEREIN). 
 CARDIOVASCULAR BIOTHERAPEUTICS, INC.

 WARRANT TO PURCHASE COMMON STOCK 
  

					
	Warrant No.: _______	  		  	Number of Shares: ____
	Date of Issuance: March 20, 2006	  		  	

 CardioVascular BioTherapeutics, Inc., a Delaware corporation (the “Company”), hereby certifies
that, for Ten United States Dollars ($10.00) and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, ____________________, the registered holder hereof or its permitted assigns, is entitled, subject
to the terms set forth below, to purchase from the Company upon surrender of this Warrant (if required by Section 2(f)), at any time or times on or after the date hereof, but not after 11:59 P.M. New York Time on the Expiration Date (as defined
in Section 1(b) below) [INSERT: the quotient of (a) 30% of the original principal amount of the Notes purchased by the holder at the Closing, divided by (b) the Warrant Exercise Price as of the Closing Date] fully paid
nonassessable shares of Common Stock (as defined in Section 1(b) below) of the Company (the “Warrant Shares”) at the Warrant Exercise Price (as defined in Section 1(b) below); provided, however, that in no event shall the
holder be entitled or required to exercise this Warrant for a number of Warrant Shares in excess of that number of Warrant Shares that, upon giving effect to such exercise, would cause the aggregate number of shares of Common Stock beneficially
owned by the holder and its affiliates to exceed 4.99% of the outstanding shares of the Common Stock following such 

 
exercise. For purposes of the foregoing proviso, the aggregate number of shares of Common Stock beneficially owned by the holder and its affiliates shall
include the number of shares of Common Stock issuable upon exercise of this Warrant with respect to which the determination of such proviso is being made, but shall exclude shares of Common Stock that would be issuable upon (i) exercise of the
remaining, unexercised SPA Warrants (as defined in Section 1(a) below) beneficially owned by the holder and its affiliates and (ii) exercise, conversion or exchange of the unexercised, unconverted or unexchanged portion of any other
securities of the Company beneficially owned by the holder and its affiliates (including the Notes, Repurchase Warrants (as defined in the Notes), if any, and any other convertible notes or preferred stock) subject to a limitation on conversion,
exercise or exchange analogous to the limitation contained herein. Except as set forth in the preceding sentence, for purposes of this paragraph, beneficial ownership shall be calculated in accordance with Section 13(d) of the Securities
Exchange Act of 1934, as amended. For purposes of this Warrant, in determining the number of outstanding shares of Common Stock a holder may rely on the number of outstanding shares of Common Stock as reflected in (1) the Company’s most
recent Form 10-Q or Form 10-K, as the case may be, (2) a more recent public announcement by the Company or (3) any other written (including e-mail) notice by the Company or its transfer agent setting forth the number of shares of Common
Stock outstanding. Upon the written request of any holder, the Company shall promptly, but in no event later than two (2) Business Days following the receipt of such request, confirm in writing to any such holder the number of shares of Common
Stock then outstanding. In any case, the number of outstanding shares of Common Stock shall be determined after giving effect to the conversion, exercise or exchange of securities of the Company, including the SPA Warrants, the Notes and the
Repurchase Warrants, if any, by such holder and its affiliates, since the date as of which such number of outstanding shares of Common Stock was reported. For purposes of determining the maximum number of shares of Common Stock that the Company may
issue to the holder of this Warrant upon exercise of this Warrant, such holder’s delivery of an Exercise Notice (as defined in Section 2(a) below) with respect to such exercise shall constitute a representation (on which the Company may
rely without investigation) by the holder of this Warrant that upon the issuance of the shares of Common Stock to be issued to such holder pursuant to such exercise, the shares of Common Stock beneficially owned by such holder and its affiliates
shall not exceed 4.99% of the total outstanding shares of Common Stock of the Company immediately after giving effect to such exercise as determined in accordance with this paragraph. 
 Section 1. 
 (a)
Securities Purchase Agreement. This Warrant is one of the warrants issued pursuant to Section 1 of that certain Securities Purchase Agreement dated as of March 20, 2006, among the Company and the Persons (as defined below) referred
to therein (as such agreement may be amended from time to time as provided in such agreement, the “Securities Purchase Agreement”) or issued in exchange or substitution therefor or replacement thereof (all such warrants being
collectively referred to as the “SPA Warrants”). Each capitalized term used, and not otherwise defined herein, shall have the meaning ascribed thereto in the Securities Purchase Agreement. 
  

 -2- 

 (b) Definitions. The following words and terms as used in this Warrant shall have
the following meanings: 
 (i) “Approved Stock Plan” means any employee benefit plan that has been approved
by the Board of Directors and stockholders of the Company prior to the date of the Securities Purchase Agreement, pursuant to which the Company’s securities may be issued to any consultant, employee, officer or director for services provided to
the Company. 
 (ii) “Business Day” means any day other than Saturday, Sunday or other day on which
commercial banks in the City of New York are authorized or required by law to remain closed. 
 (iii) “Common
Stock” means (i) the Company’s common stock, $0.001 par value per share, and (ii) any capital stock into which such Common Stock shall have been changed or any capital stock resulting from a reclassification of such Common
Stock. 
 (iv) “Convertible Securities” means any stock or securities (other than Options) directly or
indirectly convertible into or exchangeable or exercisable for Common Stock. 
 (v) “Expiration Date” means
the date that is three (3) years after the Warrant Date (as defined in Section 13) or, if such date does not fall on a Business Day, then the next Business Day. 
 (vi) “Person” means an individual, a limited liability company, a partnership, a joint venture, a corporation, a trust,
an unincorporated organization or a government or any department or agency thereof or any other legal entity. 
 (vii)
“Securities Act” means the Securities Act of 1933, as amended. 
 (viii) “Trading Day” means
any day on which the Common Stock is traded on the Principal Market; provided that “Trading Day” shall not include any day on which the Common Stock is scheduled to trade, or actually trades, on such exchange or market for less than 4.5
hours. 
 (ix) “Warrant” means this Warrant and all Warrants issued in exchange, transfer or replacement
thereof pursuant to the terms of this Warrant. 
 (x) “Warrant Exercise Price” shall be equal to, with
respect to any Warrant Share, $8.50, subject to adjustment as hereinafter provided. 
 (xi) “Weighted Average
Price” means, for any security as of any date, the dollar volume-weighted average price for such security on its Principal Market during the period beginning at 9:30 a.m. New York City time (or such other time as its Principal Market
publicly announces is the official open of trading) and ending at 4:00 p.m. New York City time (or such other time as its Principal Market publicly announces is the official close of trading) as reported by Bloomberg Financial Markets (or any
successor thereto) (“Bloomberg”) through its “Volume at Price” functions, or if the foregoing does not apply, the dollar volume-weighted 

  

 -3- 

 
average price of such security in the over-the-counter market on the electronic bulletin board for such security during the period beginning at 9:30 a.m. New
York City time (or such other time as such over-the-counter market publicly announces is the official open of trading), and ending at 4:00 p.m. New York City time (or such other time as such over-the-counter market publicly announces is the official
close of trading) as reported by Bloomberg, or, if no dollar volume-weighted average price is reported for such security by Bloomberg for such hours, the average of the highest closing bid price and the lowest closing ask price of any of the market
makers for such security as reported in the “pink sheets” by the National Quotation Bureau, Inc. If the Weighted Average Price cannot be calculated for such security on such date on any of the foregoing bases, the Weighted Average Price of
such security on such date shall be the fair market value as mutually determined by the Company and the holder of this Warrant. If the Company and the holder of this Warrant are unable to agree upon the fair market value of the Common Stock, then
such dispute shall be resolved pursuant to Section 2(a). All such determinations shall be appropriately adjusted for any stock dividend, stock split, stock combination or other similar transaction during any period during which the Weighted
Average Price is being determined. 
 Section 2. Exercise of Warrant. 
 (a) Subject to the terms and conditions hereof, this Warrant may be exercised by the holder hereof then registered on the books of the
Company, in whole or in part, at any time on any Business Day on or after the opening of business on the date hereof and prior to 11:59 P.M. New York Time on the Expiration Date by (i) delivery of a written notice, in the form of the exercise
notice attached as Exhibit A hereto (the “Exercise Notice”), of such holder’s election to exercise this Warrant, which notice shall specify the number of Warrant Shares to be purchased, (ii) (A) payment to the
Company of an amount equal to the Warrant Exercise Price multiplied by the number of Warrant Shares as to which this Warrant is being exercised (the “Aggregate Exercise Price”) by wire transfer of immediately available funds (or by
check if the Company has not provided the holder of this Warrant with wire transfer instructions for such payment) or (B) by notifying the Company that this Warrant is being exercised pursuant to a Cashless Exercise (as defined in
Section 2(e)), and (iii) if required by Section 2(f) or unless the holder has previously delivered this Warrant to the Company and it or a new replacement Warrant has not yet been delivered to the holder, the surrender to a common
carrier for overnight delivery to the Company as soon as practicable following such date, of this Warrant (or an indemnification undertaking, in customary form, with respect to this Warrant in the case of its loss, theft or destruction pursuant to
Section 10); provided, that if such Warrant Shares are to be issued in any name other than that of the registered holder of this Warrant, such issuance shall be deemed a transfer and the provisions of Section 7 shall be applicable. In the
event of any exercise of the rights represented by this Warrant in compliance with this Section 2(a), on the second (2nd) Business Day (the “Warrant Share Delivery Date”) following the date of its receipt of the Exercise Notice, the Aggregate Exercise Price (or notice of Cashless Exercise) and if required by Section 2(f) (or
unless the holder of this Warrant has previously delivered this Warrant to the Company and it or a new replacement Warrant has not yet been delivered to the holder), this Warrant (or an indemnification undertaking, in customary form, with respect to
this Warrant in the case of its loss, theft or destruction pursuant to Section 10) (the “Exercise Delivery Documents”), (A) provided that the transfer agent is participating in The Depository Trust Company
(“DTC”) Fast Automated Securities Transfer Program and provided that the holder is eligible to receive shares through DTC, the Company shall credit such 

  

 -4- 

 
aggregate number of shares of Common Stock to which the holder shall be entitled to the holder’s or its designee’s balance account with DTC through
its Deposit Withdrawal Agent Commission system or (B) the Company shall issue and deliver to the address specified in the Exercise Notice, a certificate, registered in the name of the holder or its designee, for the number of shares of Common
Stock to which the holder shall be entitled. Upon the later of the date of delivery of (x) the Exercise Notice and (y) the Aggregate Exercise Price referred to in clause (ii)(A) above or notification to the Company of a Cashless Exercise
referred to in Section 2(e), the holder of this Warrant shall be deemed for all purposes to have become the holder of record of the Warrant Shares with respect to which this Warrant has been exercised (the date thereof being referred to as the
“Deemed Issuance Date”), irrespective of the date of delivery of this Warrant as required by clause (iii) above or the certificates evidencing such Warrant Shares. In the case of a dispute as to the determination of the Warrant
Exercise Price, the Weighted Average Price of a security or the arithmetic calculation of the number of Warrant Shares, the Company shall promptly issue to the holder the number of shares of Common Stock that is not disputed and shall submit the
disputed determinations or arithmetic calculations to the holder via facsimile within two (2) Business Days after receipt of the holder’s Exercise Notice. If the holder and the Company are unable to agree upon the determination of the
Warrant Exercise Price, the Weighted Average Price or arithmetic calculation of the number of Warrant Shares within three (3) Business Days of such disputed determination or arithmetic calculation being submitted to the holder, then the Company
shall immediately submit via facsimile (i) the disputed determination of the Warrant Exercise Price or the Weighted Average Price to an independent, reputable investment banking firm agreed to by the Company and the holder of this Warrant or
(ii) the disputed arithmetic calculation of the number of Warrant Shares to its independent, outside public accountant. The Company shall cause the investment banking firm or the accountant, as the case may be, to perform the determinations or
calculations and notify the Company and the holder of the results no later than three (3) Business Days after the time it receives the disputed determinations or calculations. Such investment banking firm’s or accountant’s
determination or calculation, as the case may be, shall be deemed conclusive absent error. 
 (b) If this Warrant is submitted
for exercise, as may be required by Section 2(f), and unless the rights represented by this Warrant shall have expired or shall have been fully exercised, the Company shall, as soon as practicable and in no event later than three
(3) Business Days after receipt of this Warrant (the “Warrant Delivery Date”) and at its own expense, issue a new Warrant identical in all respects to this Warrant exercised except it shall represent rights to purchase the
number of Warrant Shares purchasable immediately prior to such exercise under this Warrant, less the number of Warrant Shares with respect to which such Warrant is exercised (together with, in the case of a Cashless Exercise, the number of Warrant
Shares surrendered in lieu of payment of the Exercise Price). 
 (c) No fractional shares of Common Stock are to be issued
upon the exercise of this Warrant, but rather the number of shares of Common Stock issued upon exercise of this Warrant shall be rounded up or down to the nearest whole number (with 0.5 rounded up). 
 (d) If the Company shall fail for any reason or for no reason (x) to issue and deliver to the holder within three (3) Business
Days of receipt of the Exercise Delivery Documents a certificate for the number of shares of Common Stock to which the holder is 

  

 -5- 

 
entitled or to credit the holder’s balance account with DTC for such number of shares of Common Stock to which the holder is entitled upon the
holder’s exercise of this Warrant or (y) to issue and deliver to the holder on the Warrant Delivery Date a new Warrant for the number of shares of Common Stock to which such holder is entitled pursuant to Section 2(b) hereof, if any,
then the Company shall, in addition to any other remedies under this Warrant or the Securities Purchase Agreement or otherwise available to such holder, including any indemnification under Section 8 of the Securities Purchase Agreement, pay as
additional damages in cash to such holder on each day after such third (3rd) Business Day that such shares of Common Stock are not issued and delivered to the holder, in the case of clause (x) above, or such third (3rd) Business Day
that such Warrant is not delivered, in the case of clause (y) above, an amount equal to the sum of (i) 0.5% of the product of (A) the number of shares of Common Stock not issued to the holder on or prior to the Warrant Share Delivery
Date and (B) the Weighted Average Price of the Common Stock on the Warrant Share Delivery Date, in the case of the failure to deliver Common Stock, and (ii) if the Company has failed to deliver a Warrant to the holder on or prior to the
Warrant Delivery Date, 0.5% of the product of (x) the number of shares of Common Stock issuable upon exercise of the Warrant as of the Warrant Delivery Date, and (y) the Weighted Average Price of the Common Stock on the Warrant Delivery
Date; provided that in no event shall cash damages accrue pursuant to this Section 2(d) during the period, if any, in which any Warrant Shares are the subject of a bona fide dispute that is subject to and being resolved pursuant to, and in
compliance with the time periods and other provisions of, the dispute resolution provisions of Section 2(a). Alternatively, subject to the dispute resolution provisions of Section 2(a), at the election of the holder made in the
holder’s sole discretion, the Company shall pay to the holder, in lieu of the additional damages referred to in the preceding sentence (but in addition to all other available remedies that the holder may pursue hereunder and under the
Securities Purchase Agreement (including indemnification pursuant to Section 8 thereof)), 110% of the amount that (A) the holder’s total purchase price (including brokerage commissions, if any) for shares of Common Stock purchased to
make delivery in satisfaction of a sale by such holder of the shares of Common Stock to which the holder is entitled but has not received upon an exercise, exceeds (B) the net proceeds received by the holder from the sale of the shares of
Common Stock to which the holder is entitled but has not received upon such exercise. 
 (e) If, despite the Company’s
obligations under the Securities Purchase Agreement and the Registration Rights Agreement, the Warrant Shares to be issued are not registered and available for resale pursuant to a registration statement in accordance with the Registration Rights
Agreement, including during a Grace Period (as defined in the Registration Rights Agreement), then notwithstanding anything contained herein to the contrary, the holder of this Warrant may, at its election exercised in its sole discretion, exercise
this Warrant in whole or in part and, in lieu of making the cash payment otherwise contemplated to be made to the Company upon such exercise in payment of the Aggregate Exercise Price, elect instead to receive upon such exercise the “Net
Number” of shares of Common Stock determined according to the following formula (a “Cashless Exercise”): 
 Net Number
= (A x B) - (A x C) 
   B 
 For purposes of the foregoing formula: 
 A= the total number of shares with respect to which this Warrant is
then being exercised; 
 B= the Weighted Average Price of the Common Stock on the Trading Day immediately preceding the date of the delivery
of the Exercise Notice; and 
 C= the Warrant Exercise Price then in effect for the applicable Warrant Shares at the time of such exercise.

  

 -6- 

 (f) Book-Entry. Notwithstanding anything to the contrary set forth herein, upon
exercise of this Warrant in accordance with the terms hereof, the holder of this Warrant shall not be required to physically surrender this Warrant to the Company unless it is being exercised for all of the Warrant Shares represented by the Warrant.
The holder and the Company shall maintain records showing the number of Warrant Shares exercised and issued and the dates of such exercises or shall use such other method, reasonably satisfactory to the holder and the Company, so as not to require
physical surrender of this Warrant upon each such exercise. In the event of any dispute or discrepancy, such records of the Company establishing the number of Warrant Shares to which the holder is entitled shall be controlling and determinative in
the absence of demonstrable error. Notwithstanding the foregoing, if this Warrant is exercised as aforesaid, the holder may not transfer this Warrant unless the holder first physically surrenders this Warrant to the Company, whereupon the Company
will forthwith issue and deliver upon the order of the holder a new Warrant of like tenor, registered as the holder may request, representing in the aggregate the remaining number of Warrant Shares represented by this Warrant. The holder and any
assignee, by acceptance of this Warrant, acknowledge and agree that, by reason of the provisions of this paragraph, following exercise of any portion of this Warrant, the number of Warrant Shares represented by this Warrant may be less than the
number stated on the face hereof. Each Warrant shall bear the following legend: 
 ANY TRANSFEREE OF THIS WARRANT SHOULD CAREFULLY REVIEW THE
TERMS OF THIS WARRANT, INCLUDING SECTION 2(f) HEREOF. THE SECURITIES REPRESENTED BY THIS WARRANT MAY BE LESS THAN THE NUMBER SET FORTH ON THE FACE HEREOF PURSUANT TO SECTION 2(f) HEREOF. 
 Section 3. Covenants as to Common Stock. The Company hereby covenants and agrees as follows: 
 (a) This Warrant is, and any Warrants issued in substitution for or replacement of this Warrant will upon issuance be, duly authorized and
validly issued. 
  

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 (b) All Warrant Shares that may be issued upon the exercise of the rights represented by
this Warrant will, upon issuance and receipt of payment therefor from the holder (including pursuant to a Cashless Exercise, as applicable), be validly issued, fully paid and nonassessable and free from all taxes, liens and charges with respect to
the issue thereof. 
 (c) During the period within which the rights represented by this Warrant may be exercised, the Company
will at all times have authorized and reserved at least 110% of the number of shares of Common Stock needed to provide for the exercise of the rights then represented by this Warrant. 
 (d) If, and so long as, any shares of Common Stock shall be listed on the NASDAQ Capital Market or another securities exchange or market,
the shares of Common Stock issuable upon exercise of this Warrant shall be so listed; and the Company shall so list on such exchange or market, and shall maintain such listing of, any other shares of capital stock of the Company issuable upon the
exercise of this Warrant if and so long as any shares of the same class shall be listed on such securities exchange or market. 
 (e) The Company will not, by amendment of its Certificate of Incorporation or through any reorganization, transfer of assets, consolidation, merger, dissolution, issue or sale of securities, or any other voluntary action, avoid or seek to
avoid the observance or performance of any of the terms to be observed or performed by it hereunder, but will at all times in good faith assist in the carrying out of all the provisions of this Warrant. Without limiting the generality of the
foregoing, the Company (i) will not increase the par value of any shares of Common Stock receivable upon the exercise of this Warrant above $0.001 per share, and (ii) will take all such actions as may be necessary or appropriate in order
that the Company may validly and legally issue fully paid and nonassessable shares of Common Stock upon the exercise of this Warrant. 
 (f) This Warrant will be binding upon any entity succeeding to the Company by merger, consolidation or acquisition of all or substantially all of the Company’s assets. 
 Section 4. Taxes. The Company shall pay any and all taxes that may be payable with respect to the issuance and delivery of Warrant Shares upon
exercise of this Warrant. 
 Section 5. Warrant Holder Not Deemed a Stockholder. No holder, as such, of this Warrant shall be entitled
to vote or receive dividends or be deemed the holder of shares of the Company for any purpose (other than to the extent that the holder is deemed to be a beneficial holder of shares under applicable securities laws after taking into account the
limitation set forth in the first paragraph of this Warrant), nor shall anything contained in this Warrant be construed to confer upon the holder hereof, as such, any of the rights of a stockholder of the Company or any right to vote, give or
withhold consent to any corporate action (whether any reorganization, issue of stock, reclassification of stock, consolidation, merger, conveyance or otherwise), receive notice of meetings, receive dividends or subscription rights, or otherwise,
prior to the Deemed Issuance Date of the Warrant Shares that such holder is then entitled to receive upon the due exercise of this Warrant. In addition, nothing contained in this Warrant shall be construed as imposing any liabilities on such holder
to purchase any securities (except to the extent set forth in an Exercise Notice) or as a stockholder of the Company, whether such liabilities are asserted 

  

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by the Company or by creditors of the Company. Notwithstanding this Section 5, the Company will provide the holder of this Warrant with copies of the
same notices and other information given to the stockholders of the Company generally, contemporaneously with the giving thereof to the stockholders. 
 Section 6. Representations of Holder. The holder of this Warrant, by the acceptance hereof, represents that it is acquiring this Warrant, and upon exercise hereof (other than pursuant to a Cashless Exercise)
will acquire the Warrant Shares, for its own account and not with a view towards, or for resale in connection with, the public sale or distribution of this Warrant or the Warrant Shares, except pursuant to sales registered or exempted under the
Securities Act; provided, however, that by making the representations herein, the holder does not agree to hold this Warrant or any of the Warrant Shares for any minimum or other specific term and reserves the right to dispose of this Warrant and
the Warrant Shares at any time in accordance with or pursuant to a registration statement or an exemption under the Securities Act. The holder of this Warrant further represents, by acceptance hereof, that, as of this date, such holder is an
“accredited investor” as such term is defined in Rule 501(a)(3) of Regulation D promulgated by the Securities and Exchange Commission under the Securities Act. Each delivery of an Exercise Notice, other than in connection with a Cashless
Exercise, shall constitute confirmation at such time by the holder of the representations concerning the Warrant Shares set forth in the first two sentences of this Section 6, unless contemporaneous with the delivery of such Exercise Notice the
holder notifies the Company in writing that it is not making such representations (a “Representation Notice”). If the holder delivers a Representation Notice in connection with an exercise, it shall be a condition to such
holder’s exercise of this Warrant and the Company’s obligations set forth in Section 2 in connection with such exercise, that the Company receive such other representations as the Company considers reasonably necessary to assure the
Company that the issuance of its securities upon exercise of this Warrant shall not violate any United States or state securities laws. 
 Section 7. Ownership and Transfer. 
 (a) The Company shall maintain at its principal executive offices (or
such other office or agency of the Company as it may designate by notice to the holder), a register for this Warrant, in which the Company shall record the name and address of the person in whose name this Warrant has been issued, as well as the
name and address of each transferee. The Company may treat the person in whose name any Warrant is registered on the register as the owner and holder thereof for all purposes, notwithstanding any notice to the contrary, but in all events recognizing
any transfers made in accordance with the terms of this Warrant. 
 (b) This Warrant and the rights granted hereunder shall be
assignable by the holder hereof in accordance with the Securities Purchase Agreement. Holder shall require each such assignee to acknowledge that such assignee shall be bound by the provisions of Section 4(r) of the Securities Purchase
Agreement. 
 (c) The Company is obligated to register the Warrant Shares for resale under the Securities Act pursuant to the
Registration Rights Agreement and the initial holder of this Warrant (and certain assignees thereof) is entitled to the registration rights in respect of the Warrant Shares as set forth in the Registration Rights Agreement. 
  

 -9- 

 Section 8. Adjustment of Warrant Exercise Price and Number of Warrant Shares. The Warrant Exercise
Price and the number of shares of Common Stock issuable upon exercise of this Warrant shall be adjusted from time to time as follows: 
 (a) Adjustment of Warrant Exercise Price and Number of Shares upon Issuance of Common Stock. If and whenever on or after the Warrant Date (as defined in Section 13), the Company issues or sells, or is
deemed to have issued or sold, any shares of Common Stock (including the issuance or sale of shares of Common Stock owned or held by or for the account of the Company, but excluding Exempted Issuances (as defined below)), for a consideration per
share less than a price (the “Applicable Price”) equal to the Warrant Exercise Price in effect immediately prior to such issuance or sale, then immediately after such issue or sale the Warrant Exercise Price then in effect shall be
reduced to an amount equal to such consideration per share. Upon each such adjustment of the Warrant Exercise Price pursuant to the immediately preceding sentence, the number of shares of Common Stock acquirable upon exercise of this Warrant shall
be adjusted to the number of shares determined by multiplying the Warrant Exercise Price in effect immediately prior to such adjustment by the number of shares of Common Stock acquirable upon exercise of this Warrant immediately prior to such
adjustment and dividing the product thereof by the Warrant Exercise Price resulting from such adjustment. For purposes of this Warrant, “Exempted Issuances” shall mean: (I) shares of Common Stock issued or deemed to be issued
by the Company pursuant to an Approved Stock Plan; (II) shares of Common Stock issued or deemed to be issued by the Company upon the conversion, exchange or exercise of any right, option, obligation or security outstanding on the date prior to the
Warrant Date and set forth in Schedule 3(c) to the Securities Purchase Agreement, provided that the terms of such right, option, obligation or security are not amended or otherwise modified on or after the date of the Securities Purchase Agreement,
and provided that the conversion price, exchange price, exercise price or other purchase price is not reduced, adjusted or otherwise modified and the number of shares of Common Stock issued or issuable is not increased (whether by operation of, or
in accordance with, the relevant governing documents or otherwise) on or after the date of the Securities Purchase Agreement, or (III) shares of Common Stock issued or deemed to be issued by the Company upon conversion of the Notes or exercise of
the SPA Warrants or the Repurchase Warrants. 
 (b) Effect on Warrant Exercise Price of Certain Events. For purposes of
determining the adjusted Warrant Exercise Price under Section 8(a) above (which, for the avoidance of doubt, the Company expressly agrees shall mean, at any date after the Warrant Date, for all purposes of this Section 8, including for
purposes of determining whether the Company has issued or sold, or shall be deemed to have issued or sold, any shares of Common Stock for a consideration per share less than a price equal to the Applicable Price), the following shall be applicable:

 (i) Issuance of Options. If the Company in any manner grants or sells any Options (other than pursuant to an
Approved Stock Plan) and the lowest price per share for which one share of Common Stock is issuable upon the exercise of any such Option or upon conversion, exchange or exercise of any Convertible Securities issuable upon exercise of any such Option
is less than the Applicable Price, then such share of Common Stock shall be deemed to be outstanding and to have been issued and sold by the Company at the time of the granting or sale of such Option for such price per share. For purposes of this
Section 8(b)(i), the “lowest 

  

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price per share for which one share of Common Stock is issuable upon exercise of any such Option or upon conversion, exchange or exercise of any Convertible
Security issuable upon exercise of any such Option” shall be equal to the sum of the lowest amounts of consideration (if any) received or receivable by the Company with respect to any one share of Common Stock upon the granting or sale of the
Option, upon exercise of the Option and upon conversion, exchange or exercise of any Convertible Security issuable upon exercise of such Option. No further adjustment of the Warrant Exercise Price shall be made upon the actual issuance of such
Common Stock or of such Convertible Securities upon the exercise of such Options or upon the actual issuance of such Common Stock upon conversion, exchange or exercise of such Convertible Securities. 
 (ii) Issuance of Convertible Securities. If the Company in any manner issues or sells any Convertible Securities and the lowest
price per share for which one share of Common Stock is issuable upon such conversion, exchange or exercise thereof is less than the Applicable Price, then such share of Common Stock shall be deemed to be outstanding and to have been issued and sold
by the Company at the time of the issuance or sale of such Convertible Securities for such price per share. For the purposes of this Section 8(b)(ii), the “lowest price per share for which one share of Common Stock is issuable upon such
conversion, exchange or exercise” shall be equal to the sum of the lowest amounts of consideration (if any) received or receivable by the Company with respect to one share of Common Stock upon the issuance or sale of the Convertible Security
and upon conversion, exchange or exercise of such Convertible Security. No further adjustment of the Warrant Exercise Price shall be made upon the actual issuance of such Common Stock upon conversion, exchange or exercise of such Convertible
Securities, and if any such issue or sale of such Convertible Securities is made upon exercise of any Options for which adjustment of the Warrant Exercise Price had been or are to be made pursuant to other provisions of this Section 8(b), no
further adjustment of the Warrant Exercise Price shall be made by reason of such issue or sale. 
 (iii) Change in Option
Price or Rate of Conversion. If the purchase, exchange or exercise price provided for in any Options, the additional consideration, if any, payable upon the issue, conversion, exchange or exercise of any Convertible Securities, or the rate at
which any Options or Convertible Securities are convertible into or exchangeable or exercisable for Common Stock changes at any time, the Warrant Exercise Price in effect at the time of such change shall be adjusted to the Warrant Exercise Price
that would have been in effect at such time had such Options or Convertible Securities provided for such changed purchase, exchange or exercise price, additional consideration or changed conversion rate, as the case may be, at the time initially
granted, issued or sold and the number of shares of Common Stock acquirable hereunder shall be correspondingly readjusted. For purposes of this Section 8(b)(iii), if the terms of any Option or Convertible Security that was outstanding as of the
date of issuance of this Warrant are changed in the manner described in the immediately preceding sentence, then such Option or Convertible Security and the Common Stock deemed issuable upon exercise, conversion or exchange thereof shall be deemed
to have been issued as of the date of such change. No adjustment shall be made if such adjustment would result in an increase of the Warrant Exercise Price then in effect. 
 (c) Effect on Warrant Exercise Price of Certain Events. For purposes of determining the adjusted Warrant Exercise Price under
Sections 8(a) and 8(b) above (which, for 

  

 -11- 

 
the avoidance of doubt, the Company expressly agrees shall mean, at least as of any date after the Warrant Date, for all purposes of this Section 8,
including for purposes of determining whether the Company has issued or sold, or shall be deemed to have issued or sold, any shares of Common Stock for a consideration per share less than a price equal to the Applicable Price), the following shall
be applicable: 
 (i) Calculation of Consideration Received. In case any Options are issued in connection with the
issue or sale of other securities of the Company, together comprising one integrated transaction or series of related transactions, (A) the Options will be deemed to have been issued for a consideration equal to the greatest of (I) $0.01,
(II) the specific aggregate consideration, if any, allocated to such Options, and (III) the Black-Scholes Value (as defined below) of such Options (the greatest of (I), (II) and (III), the “Option Consideration”) and, for purposes
of applying the provisions of this Section 8, the Option Consideration shall be allocated pro rata among all the shares of Common Stock issuable upon exercise of such Options to determine the consideration per each such share of Common Stock
and (B) the other securities will be deemed to have been issued for an aggregate consideration equal to the aggregate consideration received by the Company for the Options and other securities (determined as provided below with respect to each
share of Common Stock represented thereby), less the Option Consideration. If any Common Stock, Options or Convertible Securities are issued or sold or deemed to have been issued or sold for cash, the consideration received therefor will be deemed
to be the net amount received by the Company therefor. If any Common Stock, Options or Convertible Securities are issued or sold for a consideration other than cash, the amount of such consideration received by the Company will be the fair value of
such consideration, except where such consideration consists of marketable securities, in which case the amount of consideration received by the Company will be the Weighted Average Price of such securities on the date of receipt of such securities.
If any Common Stock, Options or Convertible Securities are issued to the owners of the non-surviving entity in connection with any merger in which the Company is the surviving entity, the amount of consideration therefor will be deemed to be the
fair value of such portion of the net assets and business of the non-surviving entity as is attributable to such Common Stock, Options or Convertible Securities, as the case may be. The fair value of any consideration other than cash or securities
will be determined jointly by the Company and the holder of this Warrant. If such parties are unable to reach agreement within ten (10) days after the occurrence of an event requiring valuation (the “Valuation Event”), the fair
value of such consideration will be determined within five (5) Business Days after the tenth (10th) day following the Valuation Event by an independent, reputable appraiser jointly selected by the Company and the holder of this Warrant.
The determination of such appraiser shall be final and binding upon all parties absent error, and the fees and expenses of such appraiser shall be borne by the Company. 
 (ii) Record Date. If the Company takes a record of the holders of Common Stock for the purpose of entitling them (1) to
receive a dividend or other distribution payable in Common Stock, Options or in Convertible Securities or (2) to subscribe for or purchase Common Stock, Options or Convertible Securities, then such record date will be deemed to be the date of
the issue or sale of the shares of Common Stock deemed to have been issued or sold upon the declaration of such dividend or the making of such other distribution or the date of the granting of such right of subscription or purchase, as the case may
be. 
  

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 (iii) Black-Scholes Value. The “Black-Scholes Value” of any
Options shall mean the sum of the amounts resulting from applying the Black-Scholes pricing model to each such Option, which calculation is made with the following inputs: (i) the “option striking price” being equal to the
lowest exercise price possible under the terms of such Option on the date of the issuance of such Option (the “Valuation Date”), (ii) the “interest rate” being equal to the Federal Reserve US H.15 T Note Treasury
Constant Maturity 1 Year rate on the Valuation Date (as reported by Bloomberg through its “ALLX H15T” function (accessed by typing “ALLX H15T” [GO] on a Bloomberg terminal, and inserting the date of the Valuation Date and then
looking at the row entitled “Treas Const Mat 1 Year” under the column entitled “Previous Value”)), or if such rate is not available then such other similar rate as mutually agreed to by the Company and the holders of Notes and
the SPA Warrants and Repurchase Warrants, if any, representing at least two-thirds (2/3) of the aggregate number of shares of Common Stock obtainable upon conversion of the Notes (at the then prevailing Fixed Conversion Price) then outstanding
and exercise of the SPA Warrants and the Repurchase Warrants, if any (at the then prevailing exercise prices thereof), then outstanding, without regard to any limitations on conversion or exercise thereof, (iii) the “time until option
expiration” being the time from the Valuation Date until the expiration date of such Option, (iv) the “current stock price” being equal to the Weighted Average Price of the Common Stock on the Valuation Date, (v) the
“volatility” being the 100-day historical volatility of the Common Stock as of the Valuation Date (as reported by the Bloomberg “HVT” screen), and (vi) the “dividend rate” being equal to zero. Within three
(3) Business Days after the Valuation Date, each of the Company and the Holder shall deliver to the other a written calculation of its determination of the Black-Scholes Value of the Options. If the Holder and the Company are unable to agree
upon the calculation of the Black-Scholes Value of the Options within five (5) Business Days of the Valuation Date, then the Company shall submit via facsimile the disputed calculation to an investment banking firm (jointly selected by the
Company and the holder of this Warrant) within seven (7) Business Days of the Valuation Date. The Company shall cause such investment banking firm to perform the calculations and notify the Company and the Holder of the results no later than
ten (10) Business Days after the Valuation Date. Such investment banking firm’s calculation of the Black-Scholes Value of the Options shall be deemed conclusive absent error. The Company shall bear the fees and expenses of such investment
banking firm for providing such calculation. 
 (d) Adjustment of Warrant Exercise Price upon Subdivision or Combination of
Common Stock. If the Company at any time after the date of issuance of this Warrant subdivides (by any stock split, stock dividend, recapitalization or otherwise) its outstanding shares of Common Stock into a greater number of shares, the
Warrant Exercise Price in effect immediately prior to such subdivision will be proportionately reduced and the number of shares of Common Stock obtainable upon exercise of this Warrant will be proportionately increased. If the Company at any time
after the date of issuance of this Warrant combines (by combination, reverse stock split or otherwise) its outstanding shares of Common Stock into a smaller number of shares, the Warrant Exercise Price in effect immediately prior to such combination
will be proportionately increased and the number of shares of Common Stock obtainable upon exercise of this Warrant will be proportionately decreased. Any adjustment under this Section 8(d) shall become effective at the close of business on the
date the subdivision or combination becomes effective. 
  

 -13- 

 (e) Distribution of Assets. If the Company shall declare or make any dividend or
other distribution of its assets (or rights to acquire its assets) to holders of Common Stock, by way of return of capital or otherwise (including any distribution of cash, stock or other securities, property or options by way of a dividend, spin
off, reclassification, corporate rearrangement or other similar transaction) (a “Distribution”), at any time after the issuance of this Warrant, then, in each such case: 
 (i) the Warrant Exercise Price in effect immediately prior to the close of business on the record date fixed for the determination of
holders of Common Stock entitled to receive the Distribution shall be reduced, effective as of the close of business on such record date, to a price determined by multiplying such Warrant Exercise Price by a fraction of which (A) the numerator
shall be the Weighted Average Price of the Common Stock on the Trading Day immediately preceding such record date minus the value of the Distribution (as determined in good faith by the Company’s Board of Directors) applicable to one share of
Common Stock, and (B) the denominator shall be the Weighted Average Price of the Common Stock on the trading day immediately preceding such record date; and 
 (ii) either (A) the number of Warrant Shares obtainable upon exercise of this Warrant shall be increased to a number of shares equal
to the number of shares of Common Stock obtainable immediately prior to the close of business on the record date fixed for the determination of holders of Common Stock entitled to receive the Distribution multiplied by the reciprocal of the fraction
set forth in the immediately preceding clause (i), or (B) in the event that the Distribution is of common stock of a company whose common stock is traded on a national securities exchange or a national automated quotation system, then the
holder of this Warrant shall receive an additional warrant, the terms of which shall be identical to those of this Warrant, except that such warrant shall be exercisable for the amount of the assets that would have been payable to the holder of this
Warrant pursuant to the Distribution had the holder exercised this Warrant immediately prior to such record date and with an exercise price equal to the amount by which the exercise price of this Warrant was decreased with respect to the
Distribution pursuant to the terms of the immediately preceding clause (i). 
 (f) Certain Events. If any event occurs
of the type contemplated by the provisions of this Section 8 but not expressly provided for by such provisions (including the granting of stock appreciation rights, phantom stock rights or other rights with equity features), then the
Company’s Board of Directors will make an appropriate adjustment in the Warrant Exercise Price and the number of shares of Common Stock obtainable upon exercise of this Warrant so as to protect the rights of the holders of the SPA Warrants;
provided that no such adjustment will increase the Warrant Exercise Price or decrease the number of shares of Common Stock obtainable as otherwise determined pursuant to this Section 8. 
 (g) Notices. 
 (i) As soon as reasonably practicable, but in no event later than two (2) Business Days, upon any adjustment of the Warrant Exercise Price, the Company will give written notice thereof to the holder of this Warrant, setting forth in
reasonable detail, and certifying, the calculation of such adjustment; provided, however, that neither the timing of 

  

 -14- 

 
giving any such notice nor any failure by the Company to give such a notice shall effect any such adjustment or the effective date thereof. 
 (ii) The Company will give written notice to the holder of this Warrant at least ten (10) days prior to the date on which the Company
closes its books or takes a record (A) with respect to any dividend or distribution upon the Common Stock, (B) with respect to any pro rata subscription offer to holders of Common Stock or (C) for determining rights to vote with
respect to any Organic Change (as defined below), dissolution or liquidation, provided that such information shall be made known to the public prior to or in conjunction with such notice being provided to such holder. 
 (iii) The Company will also give written notice to the holder of this Warrant at least ten (10) days prior to the date on which any
Organic Change, dissolution or liquidation will take place, provided that such information shall be made known to the public prior to or in conjunction with such notice being provided to such holder. 
 Section 9. Purchase Rights; Reorganization, Reclassification, Consolidation, Merger or Sale. (a) In addition to any adjustments pursuant to
Section 8 above, if at any time the Company grants, issues or sells any Options, Convertible Securities or rights to purchase stock, warrants, securities or other property pro rata to the record holders of any class of its capital stock (the
“Purchase Rights”), then the holder of this Warrant will be entitled to acquire, upon the terms applicable to such Purchase Rights, the aggregate Purchase Rights that such holder could have acquired if such holder had held the
number of shares of Common Stock acquirable upon complete exercise of this Warrant immediately before the date on which a record is taken for the grant, issuance or sale of such Purchase Rights, or, if no such record is taken, the date as of which
the record holders of Common Stock are to be determined for the grant, issue or sale of such Purchase Rights. 
 (b) Any
recapitalization, reorganization, reclassification, consolidation, merger, sale of all or substantially all of the Company’s assets to another Person or other transaction that is effected in such a way that holders of Common Stock are entitled
to receive (either directly or upon subsequent liquidation) stock, securities or assets with respect to or in exchange for Common Stock is referred to herein as “Organic Change.” Prior to the consummation of any (i) sale of all
or substantially all of the Company’s assets to an acquiring Person or (ii) other Organic Change following which the Company is not a surviving entity, the Company will secure from the Person purchasing such assets or the successor
resulting from such Organic Change (in each case, the “Acquiring Entity”) a written agreement (in form and substance satisfactory to the holders of SPA Warrants representing at least two-thirds (2/3) of the shares of Common
Stock obtainable upon exercise of the SPA Warrants then outstanding, without regard to any limitation on exercise thereof) to deliver to each holder of SPA Warrants in exchange for each such SPA Warrant, a security of the Acquiring Entity evidenced
by a written instrument substantially similar in form and substance to this Warrant and satisfactory to the holders of such SPA Warrant (including, an adjusted warrant exercise price equal to the value for the Common Stock reflected by the terms of
such consolidation, merger or sale, and exercisable for a corresponding number of shares of Common Stock acquirable and receivable upon exercise of such SPA Warrant (without regard to any limitations on exercises), if the value so reflected is less
than the Warrant Exercise Price in effect immediately prior to such consolidation, merger or 

  

 -15- 

 
sale). Prior to the consummation of any other Organic Change, the Company shall make appropriate provision (in form and substance satisfactory to the holders
of such SPA Warrants representing at least two-thirds (2/3) of the shares of Common Stock obtainable upon exercise of the SPA Warrants then outstanding, without regard to any limitation on exercise thereof) to ensure that each of the holders of
the SPA Warrants will thereafter have the right to acquire and receive in lieu of or in addition to (as the case may be) the shares of Common Stock immediately theretofore acquirable and receivable upon the exercise of such holder’s SPA
Warrants (without regard to any limitations on exercises), such shares of stock, securities or assets that would have been issued or payable in such Organic Change with respect to or in exchange for the number of shares of Common Stock that would
have been acquirable and receivable upon the exercise of such holder’s Warrant as of the date of such Organic Change (without taking into account any limitations or restrictions on the exerciseability of this Warrant). 
 Section 10. Lost, Stolen, Mutilated or Destroyed Warrant. If this Warrant is lost, stolen, mutilated or destroyed, the Company shall promptly, on
receipt of an indemnification undertaking in customary form (or in the case of a mutilated Warrant, the Warrant), issue a new Warrant of like denomination and tenor as this Warrant so lost, stolen, mutilated or destroyed. 
 Section 11. Notice. Any notices, consents, waivers or other communications required or permitted to be given under the terms of this Warrant must
be in writing and will be deemed to have been delivered: (i) upon receipt, when delivered personally; (ii) upon receipt, when sent by facsimile (provided confirmation of transmission is mechanically or electronically generated and kept on
file by the sending party); or (iii) one (1) Business Day after deposit with a nationally recognized overnight delivery service, in each case properly addressed to the party to receive the same. The addresses and facsimile numbers for such
communications shall be: 
 If to the Company: 
 On or before March 31, 2006: 
 CardioVascular BioTherapeutics, Inc. 
 7251 W. Lake Mead Blvd., Suite 300 
 Las
Vegas, Nevada 89128 
 Facsimile: (702) 617-5651 
 Attention: Corporate Controller 
 After March 31, 2006: 
 CardioVascular BioTherapeutics, Inc. 
 1635
Village Center Circle, Suite 250 
 Las Vegas, Nevada 89134 
 Facsimile: (702) 617-5651 
 Attention: Corporate Controller 
  

 -16- 

 With copy to: 
 Lord Bissell & Brook LLP 
 300 S. Grand Ave. 8th Floor 
 Los Angeles, CA 90071 
 Facsimile: (213) 485-1200 
 Attention:
Ronald Warner, Esq. 
 If to a holder of this Warrant, to it at the address and facsimile number set forth on the Schedule of Buyers to the Securities
Purchase Agreement, with copies to such holder’s representatives as set forth on such Schedule of Buyers, or, in the case of the holder or any other Person named above, at such other address and/or facsimile number and/or to the attention of
such other person as the recipient party has specified by written notice to the other party at least five (5) Business Days prior to the effectiveness of such change. Written confirmation of receipt (A) given by the recipient of such
notice, consent, waiver or other communication, (B) mechanically or electronically generated by the sender’s facsimile machine containing the time, date, recipient facsimile number and an image of the first page of such transmission or
(C) provided by a nationally recognized overnight delivery service shall be rebuttable evidence of personal service, receipt by facsimile or deposit with a nationally recognized overnight delivery service in accordance with clause (i),
(ii) or (iii) above, respectively. 
 Section 12. Limitation on Number of Warrant Shares. The Company shall not be obligated
to issue any Warrant Shares upon exercise of the SPA Warrants if the issuance of such shares of Common Stock would exceed that number of shares of Common Stock which the Company may issue upon exercise of the SPA Warrants, the Notes and the
Repurchase Warrants (the “Exchange Cap”) without breaching any obligations that the Company has under the rules or regulations of the Principal Market, if at the time of any determination, the Common Stock is listed on a national
securities exchange or the NASDAQ National Market (or successor thereto) or the NASDAQ Capital Market, except that such limitation shall not apply in the event that the Company (a) obtains Stockholder Approval or (b) obtains a written
opinion from outside counsel to the Company that such approval is not required, which opinion shall be reasonably satisfactory to the holders representing at least two-thirds (2/3) of the Warrant Shares then issuable upon exercise of
outstanding SPA Warrants, at any time, without regard to any limitation on exercise. Until such Stockholder Approval or written opinion is obtained, no holder of SPA Warrants shall be issued, upon exercise of the SPA Warrants, Warrant Shares in an
amount greater than the difference of (i) such holder’s Cap Allocation Amount (as defined in the Notes), minus (ii) the aggregate number of (x) Conversion Shares issued to such holder prior to such time upon conversion of any
Notes and (y) Warrant Shares issued to such holder prior to such time upon exercise of any SPA Warrants or Repurchase Warrants. In the event that any holder of SPA Warrants shall sell or otherwise transfer any of such SPA Warrants, the
transferee shall be allocated a pro rata portion of such holder’s Cap Allocation Amount. In the event that, after the Closing Date, any holder of the SPA Warrants shall convert all of such holder’s Notes and exercise all of such
holder’s SPA Warrants and Repurchase Warrants into a number of shares of Common Stock which, in the aggregate, is less than such holder’s Cap Allocation Amount, then the difference between such holder’s Cap Allocation Amount and the
number of Warrant Shares and Conversion Shares actually issued to such holder shall be allocated to the 

  

 -17- 

 
respective Cap Allocation Amounts of the remaining holders of SPA Warrants, Repurchase Warrants and Notes on a pro rata basis in proportion to the Warrant
Shares and Conversion Shares issuable upon exercise of the SPA Warrants and the Repurchase Warrants and conversion of the Notes (at the then prevailing conversion price), then held by each such holder, without regard to any limitations on conversion
or exercise. In the event that upon the delivery of an Exercise Notice the Company is prohibited from issuing Warrant Shares as a result of the operation of this Section 12, the Company shall repurchase for cash, within five (5) Business
Days, the portion of this Warrant with respect to which Warrant Shares cannot be issued as result of this Section 12, at a price per Warrant Share equal to the difference between the Weighted Average Price of the Common Stock and the Warrant
Exercise Price of such Warrant Shares as of the date of the attempted exercise. 
 Section 13. Date. The date of this Warrant is
March 20, 2006 (the “Warrant Date”). This Warrant, in all events, shall be wholly void and of no effect after 11:59 P.M., New York Time, on the Expiration Date, except that notwithstanding any other provisions hereof, the
provisions of Section 7 shall continue in full force and effect after such date as to any Warrant Shares or other securities issued upon the exercise of this Warrant. 
 Section 14. Amendment and Waiver. Except as otherwise provided herein, the provisions of the SPA Warrants may be amended and the Company may take
any action herein prohibited, or omit to perform any act herein required to be performed by it, only if the Company has obtained the written consent of the holders of SPA Warrants representing at least two-thirds (2/3) of the shares of Common
Stock obtainable upon exercise of the SPA Warrants then outstanding; provided that no such action may increase the Warrant Exercise Price of any SPA Warrant or decrease the number of shares or change the class of stock obtainable upon exercise of
any SPA Warrant without the written consent of the holder of such SPA Warrant. 
 Section 15. Descriptive Headings; Governing Law. The
descriptive headings of the several sections and paragraphs of this Warrant are inserted for convenience only and do not constitute a part of this Warrant. All questions concerning the construction, validity, enforcement and interpretation of this
Warrant shall be governed by the internal laws of the State of New York, without giving effect to any choice of law or conflict of law provision or rule (whether of the State of New York or any other jurisdiction) that would cause the application of
the laws of any jurisdiction other than the State of New York. 
 Section 16. Rules of Construction. Unless the context otherwise
requires, (a) all references to Articles, Sections, Schedules or Exhibits are to Articles, Sections, Schedules or Exhibits contained in or attached to this Warrant, (b) each accounting term not otherwise defined in this Warrant has the
meaning assigned to it in accordance with GAAP, (c) words in the singular or plural include the singular and plural and pronouns stated in either the masculine, the feminine or neuter gender shall include the masculine, feminine and neuter and
(d) the use of the word “including” in this Warrant shall be by way of example rather than limitation. 
 * * * * * *

  

 -18- 

 IN WITNESS WHEREOF, the Company has caused this Warrant to be signed as of March 20, 2006.

  

			
	CARDIOVASCULAR BIOTHERAPEUTICS, INC.
		
	 By:
	 	  
	 Name:
	 	  
	 Title:
	 	  

  

 -19- 

 EXHIBIT A TO WARRANT 
 EXERCISE NOTICE 
 TO BE EXECUTED BY THE REGISTERED HOLDER TO EXERCISE THIS
WARRANT 
 CARDIOVASCULAR BIOTHERAPEUTICS, INC. 
 The undersigned holder hereby exercises the right to purchase _________________ of the shares of Common Stock (“Warrant Shares”) of CARDIOVASCULAR BIOTHERAPEUTICS, INC., a Delaware corporation (the
“Company”), evidenced by the attached Warrant (the “Warrant”). Capitalized terms used herein and not otherwise defined shall have the respective meanings set forth in the Warrant. 
 1. Form of Warrant Exercise Price. The holder intends that payment of the Warrant Exercise Price shall be made as: 
  

			
	  ̈        
	 	a “Cash Exercise” with respect to ___________________ Warrant Shares; and/or
		
	  ̈        
	 	a “Cashless Exercise” with respect to ______________ Warrant Shares (to the extent permitted by the terms of the Warrant).

 2. Payment of Warrant Exercise Price. In the event that the holder has elected a Cash Exercise
with respect to some or all of the Warrant Shares to be issued pursuant hereto, the holder shall pay the Aggregate Exercise Price in the sum of $___________________ to the Company in accordance with the terms of the Warrant. 
 3. Delivery of Warrant Shares. The Company shall deliver __________ Warrant Shares in accordance with the terms of the Warrant in the following name and
to the following address: 
 Issue to:____________________________________________________________________ 
 Facsimile Number:__________________________________________________________ 
 DTC Participant Number and Name (if electronic book entry transfer):___________________ 
 Account Number
(if electronic book entry transfer):____________________________ 
 Date: _______________ __, ______ 
  

			
	     Name of Registered Holder

		
	 By:
	 	  
	 Name:
	 	
	 Title:
	 	

  

 -20- 

 ACKNOWLEDGMENT 
 The Company hereby acknowledges this Exercise Notice and hereby directs [TRANSFER AGENT] to issue the above indicated number of shares of Common Stock in
accordance with the Transfer Agent Instructions dated ________________, 200_ from the Company and acknowledged and agreed to by [TRANSFER AGENT]. 
  

			
	CARDIOVASCULAR BIOTHERAPEUTICS, INC.
		
	 By:
	 	  
	 Name:
	 	  
	 Title:
	 	  

  

 -21- 

 EXHIBIT B TO WARRANT 
 FORM OF WARRANT POWER 
 FOR VALUE RECEIVED, the undersigned does hereby assign and transfer to
________________, Federal Identification No. __________, a warrant to purchase ____________ shares of the capital stock of Cardiovascular Biotherapeutics, Inc., a Delaware corporation, represented by warrant certificate no. _____, standing in the
name of the undersigned on the books of said corporation. The undersigned does hereby irrevocably constitute and appoint ______________, attorney to transfer the warrants of said corporation, with full power of substitution in the premises.

 Dated: _________, 200_ 
  

			
	
	  
	 Name:
	 	  
	 Title:
	 	  

  

 -22-

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