Document:

Exhibit 4.3

 

THIS WARRANT AND THE SECURITIES ISSUABLE
UPON ITS EXERCISE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR QUALIFIED OR
REGISTERED UNDER ANY STATE SECURITIES LAWS. THEY MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED OR HYPOTHECATED IN THE ABSENCE OF AN
EFFECTIVE REGISTRATION STATEMENT AS TO THE SECURITIES UNDER THE ACT AND QUALIFICATION OR REGISTRATION UNDER APPLICABLE STATE SECURITIES
LAWS OR AN OPINION OF COUNSEL SATISFACTORY TO THE CORPORATION AND ITS COUNSEL (SUCH SATISFACTION BEING TO THE FORM AND SUBSTANCE
OF THE OPINION AS WELL AS TO THE COUNSEL RENDERING THE OPINION) THAT REGISTRATION OR QUALIFICATION IS NOT REQUIRED.

 

	WAR-000503	Void after May 31, 2018

 

WARRANT TO PURCHASE SHARES

 

 

THIS WARRANT is issued
to Western Pacific Securities (the “Stockholder”) by KineMed, Inc., a Delaware corporation (the “Company.”).
This Warrant is granted as of May 31, 2013 (the “Warrant Issue Date”) pursuant to the terms of that certain Placement
Agent Agreement, dated as of September 12, 2012, between the Company and Western Pacific Securities (the “Placement Agent
Agreement”).

 

1.    Purchase
of Shares. Subject to the terms and conditions hereinafter set forth, the registered holder of this Warrant (the “Holder”)
is entitled, upon surrender of this Warrant at the principal office of the Company (or at such other place as the Company shall
notify the holder hereof in writing), to purchase from the Company up to Two Million Three Hundred One Thousand Four Hundred (2,301,400)
shares of Common Stock of Company, par value $0.001 per share (the “Shares”), as more fully described below.

 

2.    Definitions.

 

A.   Exercise Price.
The exercise price for the Shares shall be Fifteen Cents ($0.15) per share (such price, as adjusted from time to time, is herein
referred to as the “Exercise Price”).

 

B.   Exercise Period.
This Warrant shall be exercisable, in whole or in part, during the term commencing on the date of this Warrant and ending on the
expiration of this Warrant pursuant to Section 3 hereof.

 

C.   Change of
Control. The term “Change of Control” shall mean: (i) any consolidation or merger involving the Company pursuant
to which the Company’s stockholders own less than fifty percent (50%) of the voting securities of the surviving entity, or
(ii) the sale of all or substantially all of the assets of the Company.

 

3.    Exercise
of Warrant. The purchase rights represented by this Warrant are fully vested as of the date hereof and may be exercised at
the sole discretion of Holder (subject to the conditions set forth herein) commencing as of the date of issue set forth below and
continuing until the earlier to occur of the following (the “Expiration Time”):

 

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A.   5:00
p.m., California local time, on May 31, 2018.

 

B.   Any
consolidation or merger involving the Company pursuant to which the Company’s stockholders own less than fifty percent (50%)
of the voting securities of the surviving entity; or

 

C.   The
sale of all or substantially all of the assets of the Company.

 

The Company shall provide at least five
(5) days prior written notice of any event set forth in Section 3 B, C, or D. To the extent not duly exercised previously, the
Holder’s rights under this Warrant will become void from and after the Expiration Time.

 

4.    Method of
Exercise. While this Warrant remains outstanding and exercisable in accordance with Section 3 above, Holder may exercise, in
whole or in part, the purchase rights evidenced hereby. Such exercise shall be effected by:

 

A.   The delivery of a completed
and correct investor suitability questionnaire in a form satisfactory to the Company to the Secretary of the Company, representing
that the holder is an “accredited investor” as defined in Rule 501 of Regulation D promulgated under the Securities
Act of 1933, as amended (the “Act”) and amended by the Dodd-Frank Wall Street Reform and Consumer Protection Act, and
other state or federal securities laws and regulations by reason of qualification and compliance at the time of exercise;

 

		B.	The surrender of the Warrant, together with a notice of exercise to the Secretary of the Company
at its principal offices; and

 

		C.	The payment to the Company of an amount equal to the aggregate Exercise Price for the number of
Shares being purchased.

 

5.    Certificates
for Shares. Upon the exercise of the purchase rights evidenced by this Warrant, one or more certificates for the number of
Shares so purchased shall be issued as soon as practicable thereafter and in any event within thirty (30) days of the delivery
of the subscription notice.

 

6.   Issuance
of Shares. The Company covenants that the Shares, when issued pursuant to the exercise of this Warrant, will be duly and validly
issued, fully paid and non-assessable and free from all taxes, liens, and charges with respect to the issuance thereof.

 

7.    Adjustment
of Exercise Price and Number of Shares. The number of and kind of securities purchasable upon exercise of this Warrant and
the Exercise Price shall be subject to adjustment from time to time as follows:

 

A.   Subdivisions, Combinations
and Other Issuances. If the Company shall at any time prior to the expiration of this Warrant subdivide the Shares, by split-up
or otherwise, or combine its Shares, or issue additional shares of its Shares as a dividend, the number of Shares issuable on the
exercise of this Warrant shall forthwith be proportionately increased in the case of a subdivision or stock dividend, or proportionately
decreased in the case of a combination. Appropriate adjustments shall also be made to the purchase price payable per share, but
the aggregate purchase price payable for the total number of Shares purchasable under this Warrant (as adjusted) shall remain the
same. Any adjustment under this Section 7A shall become effective at the close of business on the date the subdivision or combination
becomes effective, or as of the record date of such dividend, or in the event that no record date is fixed, upon the making of
such dividend.

 

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B.   Reclassification, Reorganization
and Consolidation. In case of any reclassification, capital reorganization, or change in the capital stock of the Company (other
than as a result of a subdivision, combination, or stock dividend provided for in Section 7A above), then the Company shall make
appropriate provision so that the holder of this Warrant shall have the right at any time prior to the expiration of this Warrant
to purchase, at a total price equal to that payable upon the exercise of this Warrant, the kind and amount of shares of stock and
other securities and property receivable in connection with such reclassification, reorganization, or change by a holder of the
same number of Shares as were purchasable by the holder of this Warrant immediately prior to such reclassification, reorganization,
or change. In any such case appropriate provisions shall be made with respect to the rights and interest of the holder of this
Warrant so that the provisions hereof shall thereafter be applicable with respect to any shares of stock or other securities and
property deliverable upon exercise hereof, and appropriate adjustments shall be made to the purchase price per share payable hereunder,
provided the aggregate purchase price shall remain the same.

 

C.   Notice of Adjustment.
When any adjustment is required to be made in the number or kind of shares purchasable upon exercise of the Warrant, or in the
Exercise Price, the Company shall promptly notify the holder of such event and of the number of Shares or other securities or property
thereafter purchasable upon exercise of this Warrant.

 

8.    No Fractional
Shares or Scrip. No fractional shares or scrip representing fractional shares shall be issued upon the exercise of this Warrant,
but in lieu of such fractional shares the Company shall make a cash payment therefor on the basis of the Exercise Price then in
effect.

 

9.    Representations
of the Company. The Company represents that all corporate actions on the part of the Company, its officers, directors and stockholders
necessary for the sale and issuance of this Warrant have been taken.

 

		10.	Representations and Warranties by Holder. Holder
represents and warrants to the Company as follows:

 

A.   This Warrant and the Shares
issuable upon exercise thereof are being acquired for its own account, for investment and not with a view to, or for resale in
connection with, any distribution or public offering thereof within the meaning of the Securities Act of 1933, as amended (the
“Act”). Upon exercise of this Warrant, the holder shall, if so requested by the Company, confirm in writing, in a form
satisfactory to the Company, that the securities issuable upon exercise of this Warrant are being acquired for investment and not
with a view toward distribution or resale.

 

B.   Holder understands that
the Warrant and the Shares have not been registered under the Act by reason of their issuance in a transaction exempt from the
registration and prospectus delivery requirements of the Act pursuant to Section 4(2) thereof, they must be held by the holder
indefinitely, and the holder must therefore bear the economic risk of such investment indefinitely, unless a subsequent disposition
thereof is registered under the Act or is exempted from such registration. Holder further understands that the Warrant Shares have
not been qualified under the California Securities Law of 1968 (“California Law”) by reason of their issuance in a
transaction exempt from the qualification requirements of the California Law pursuant to Section 25102(f) thereof, which exemption
depends upon, among other things, the bona fide nature of the holder’s investment intent expressed above.

 

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C.   Holder has such knowledge
and experience in financial and business matters that it is capable of evaluating the merits and risks of the purchase of this
Warrant and the Shares purchasable pursuant to the terms of this Warrant and of protecting its interests in connection therewith.

 

D.   Holder is able to bear
the economic risk of the purchase of the Shares pursuant to the terms of this Warrant.

 

E.   Holder is an “accredited
investor” as such term is defined in Rule 501 of Regulation D promulgated under the Act and amended by the Dodd-Frank Wall
Street Reform and Consumer Protection Act.

 

		11.	Restrictive Legend.

 

The Shares (unless
registered under the Act) shall be stamped or imprinted with a legend in substantially the following form:

 

THE SECURITIES REPRESENTED BY
THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR THE SECURITIES LAWS OF ANY STATE, AND
MAY NOT BE SOLD, TRANSFERRED, ASSIGNED, PLEDGED OR HYPOTHECATED UNLESS AND UNTIL REGISTERED UNDER SUCH ACT AND/OR APPLICABLE STATE
SECURITIES LAWS, OR UNLESS THE COMPANY HAS RECEIVED AN OPINION OF COUNSEL OR OTHER EVIDENCE, REASONABLY SATISFACTORY TO THE COMPANY
AND ITS COUNSEL, THAT SUCH REGISTRATION IS NOT REQUIRED.

 

12.   Warrants
Transferable. Subject to compliance with the terms and conditions of this Section 12, this Warrant and all rights hereunder
are transferable in whole without charge to the holder hereof (except for transfer taxes) upon surrender of this Warrant properly
endorsed or accompanied by written instructions of transfer. With respect to any offer, sale, or other disposition of this Warrant
or any Shares acquired pursuant to the exercise of this Warrant prior to registration of such Warrant or Shares, the holder hereof
agrees to give written notice to the Company prior thereto describing briefly the manner thereof together with a written opinion
of such holder’s counsel or other evidence, if requested by the Company, to the effect that such offer, sale, or other disposition
may be effected without registration or qualification (under the Act as then in effect or any federal or state securities law then
in effect) of this Warrant or the Shares and indicating whether or not under the Act certificates for this Warrant or the Shares
to be sold or otherwise disposed of require any restrictive legend as to applicable restrictions on transferability in order to
ensure compliance with such law. Upon receiving such written notice and reasonably satisfactory opinion or other evidence, if so
requested, the Company, as promptly as practicable, shall notify such holder that such holder may sell or otherwise dispose of
this Warrant or such Shares, all in accordance with the terms of the notice delivered to the Company. If a determination has been
made pursuant to this Section 11 that the opinion of counsel for the holder or other evidence is not reasonably satisfactory to
the Company, the Company shall so notify the holder promptly with details thereof after such determination has been made. Each
certificate representing this Warrant or the Shares transferred in accordance with this Section 12 shall bear a legend as to the
applicable restrictions on transferability in order to ensure compliance with such laws, unless in the aforesaid opinion of counsel
for the holder, such legend is not required in order to ensure compliance with such laws. The Company may issue stop transfer instructions
to its transfer agent in connection with such restrictions.

 

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13.   Rights of
Stockholders. No holder of this Warrant shall be entitled, as a Warrant holder, to vote or receive dividends or be deemed the
holder of the Shares or any other securities of the Company which may at any time be issuable on the exercise hereof for any purpose,
nor shall anything contained herein be construed to confer upon the holder of this Warrant, as such, any of the rights of a stockholder
of the Company or any right to vote for the election of directors or upon any matter submitted to stockholders at any meeting thereof,
or to give or withhold consent to any corporate action (whether upon any recapitalization, issuance of stock, reclassification
of stock, change of par value, consolidation, merger, conveyance, or otherwise) or to receive notice of meetings, or to receive
dividends or subscription rights or otherwise until the Warrant shall have been exercised and the Shares purchasable upon the exercise
hereof shall have become deliverable, as provided herein.

 

14.   Notices.
All notices and other communications required or permitted hereunder shall be in writing, shall be effective when given, and shall
in any event be deemed to be given upon receipt or, if earlier: (a) five (5) days after deposit with the U.S. Postal Service or
other applicable postal service, if delivered by first class mail, postage prepaid; (b) upon delivery, if delivered by hand; (c)
one business day after the business day of deposit with Federal Express or similar overnight courier, freight prepaid; or (d) one
business day after the business day of facsimile transmission, if delivered by facsimile transmission with copy by first class
mail, postage prepaid, and shall be addressed: (i) if to Holder, at Holder’s address set forth on Exhibit A to the Stock
Purchase Agreement, and (ii)if to the Company, at the address of its principal corporate offices (attention: CEO) or at such other
address as a party may designate by ten (10) days advance written notice to the other party pursuant to the provisions herein.

 

15.   “Market
Stand-Off” Agreement. Holder hereby agrees that it will not, without the prior written consent of the managing underwriter,
during the period commencing on the date of the final prospectus relating to the Company’s initial public offering (“IPO”)
and ending on the date specified by the Company and the managing underwriter (such period not to exceed one hundred eighty (180)
days, or such other period as may be requested by the Company or an underwriter to accommodate regulatory restrictions on (i) the
publication or other distribution of research reports and (ii) analyst recommendations and opinions, including, but not limited
to, the restrictions contained in applicable FNRA Rules or NYSE Rule 472(f)(4), or any successor provisions or amendments thereto)
(i) lend, offer, pledge, sell, contract to sell, sell any option or contract to purchase, purchase any option or contract to sell,
grant any option, right or warrant to purchase, or otherwise transfer or dispose of, directly or indirectly, any shares of Common
Stock of the Company or any securities convertible into or exercisable or exchangeable for Common Stock (whether such shares or
any such securities are then owned by the holder or are thereafter acquired), or (ii) enter into any swap or other arrangement
that transfers to another, in whole or in part, any of the economic consequences of ownership of the Common Stock, whether any
such transaction described in clause (i) or (ii) above is to be settled by delivery of Common Stock or other securities, in cash
or otherwise. The foregoing provisions of this Section 15 shall apply only to the Company’s IPO, shall not apply to the sale
of any shares to an underwriter pursuant to an underwriting agreement, and shall only be applicable to the holders if all officers
and directors enter into similar agreements and the Company uses all reasonable efforts to obtain similar agreements from all other
greater than one percent (1%) stockholders. The underwriters in connection with the Company’s IPO are intended third-party
beneficiaries of this Section 15 and shall have the right, power and authority to enforce the provisions hereof as though they
were a party hereto. Each holder further agrees to execute such agreements as may be reasonably requested by the underwriters in
the Company’s IPO that are consistent with this Section 15 or that are necessary to give further effect thereto. Any discretionary
waiver or termination of the restrictions of any or all of such agreements by the Company or the underwriters, except in the case
of legal separation, divorce or pursuant to the terms of a court order, shall apply to all holders subject to such agreements pro
rata based on the number of shares subject to such agreements, provided that, notwithstanding the foregoing, the Company and the
underwriters may, in their sole discretion, waive or terminate these restrictions with respect to up to 1% of the Company’s
outstanding Common Stock.

 

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16.   Governing
Law. This Warrant and all actions arising out of or in connection with this Agreement shall be governed by and construed in
accordance with the laws of the State of California, without regard to the conflicts of law provisions of the State of California
or of any other state, except that: (i) any matters relating to securities laws and rights related thereto shall be governed by
the applicable U.S. federal or the applicable state securities laws and regulations, and (ii) any corporate matters relating to
and specifically set forth in the General Corporation Law of the State of Delaware shall be governed by the laws of Delaware.

 

17.   Rights and
Obligations Survive Exercise of Warrant. Unless otherwise provided herein, the rights and obligations of the Company, of the
holder of this Warrant and of the holder of the Shares issued upon exercise of this Warrant, shall survive the exercise of this
Warrant.

 

18.   Entire Understanding.
This Warrant supersedes any previous understanding or agreement with respect to the subject matter hereof.

 

Issued as of May 31,
2013

 

	 	KINEMED, INC., a Delaware corporation
	 	 	 
	 	By:	/s/ David M. Fineman
	 	Name:  David M. Fineman
	 	Title:  President and Chief Executive Officer

 

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EXHIBIT A

 

NOTICE OF EXERCISE

 

	TO	KINEMED, INC.
	 	5980 Horton Street, Suite 470
	 	Emeryville, CA 94608
	 	Attention: President

 

The undersigned hereby
elects to exercise the attached Warrant and elects to purchase __________________________ Shares of Common Stock, par value $0.001
per share, of KineMed, Inc., a Delaware corporation pursuant to the terms of the attached Warrant by means of a cash payment, and
tenders herewith payment in full for the purchase price of the shares being purchased, together with all applicable transfer taxes,
if any.

 

Please issue a certificate
or certificates representing said Shares in the name of the undersigned or in such other name as is specified below:

 

	 	(Name)	 	 
	 	 	 	 
	 	(Address)	 	 

 

The undersigned hereby
represents and warrants that the aforesaid Shares are being acquired for the account of the undersigned for investment and not
with a view to, or for resale, in connection with the distribution thereof, and that the undersigned has no present intention of
distributing or reselling such shares and all representations and warranties of the undersigned set forth in Section 10 of the
attached Warrant (including Section 10E thereof) are true and correct as of the date hereof.

 

	 	 	 
	 	 	(Signature)
	 	 	 
	 	 	 
	 	 	(Name)
	 	 	 
	 	 	 
	(Date)	 	(Title)

 

    	 

    	 

    

 

EXHIBIT B

 

FORM OF TRANSFER

 

(To be signed only upon transfer of Warrant)

 

FOR VALUE RECEIVED,
the undersigned hereby sells, assigns and transfers unto __________________________ the right represented by the attached Warrant
to purchase ______ shares of __________________________ of KINEMED, INC., a Delaware corporation, to which the attached Warrant
relates, and appoints ______________ Attorney to transfer such right on the books of _________, with full power of substitution
in the premises.

 

Dated: _______________

 

	 	 	 
	 	 	(Signature must conform in all respects to name of Holder as specified on the face of the Warrant)
	 	 	 	 
	 	 	Address:	 
	 	 	 	 
	 	 	 	 
	 	 	 	 
	 	 	 	 
	 	 	 	 
	Signed in the presence of:Exhibit 10.24

 

FIFTH AMENDMENT

to

LEASE BETWEEN

 

EMERY STATION OFFICE II, LLC (LANDLORD)

And

KINEMED, INC. (TENANT)

 

EMERYSTATION NORTH PROJECT

Emeryville, California

 

That certain Lease dated May 5, 2002 by
and between Emery Station Office II, LLC (successor-in-interest to Emery Station Associates II, LLC), as Landlord, and KineMed,
Inc., as Tenant, (the “Original Lease”) as such was amended via First Amendment executed on June 27, 2003 (the “First
Amendment”), via Second Amendment whose effective date was December I, 2004 (the “Second Amendment”), via Revised
Third Amendment whose effective date was February 28, 2005 (the “Third Amendment”) and via Revised Fourth Amendment
whose effective date was March 15, 2005 (the “Fourth Amendment”), is hereby further amended as follows (the Original
Lease as amended previously by the First, Second, Third and Fourth Amendments and now by this Fifth Amendment collectively referred
to as the “Lease”):

 

		I.	The effective date of this Fifth Amendment shall be August 31, 2008 (the “Fifth Amendment
Effective Date”).

 

		II.	Landlord agrees to defer Tenant's Monthly Base Rent (but not its Rent Adjustment Deposits nor Rent
Adjustments, which must continue to be paid currently per the terms of the Lease) for the months of September and October of 2008
(the “Base Rent Deferrals”). All Base Rent Deferrals will accrue interest at the annual rate of 6.5%, compounded monthly,
from the point such Base rent would have otherwise been due per the Lease absent this Fifth Amendment. Fifty percent (50%) of the
Base Rent Deferrals, plus interest thereon, will be due and payable along with all other Rent due in November, per the terms of
the Lease. The remaining fifty percent (50%), plus interest, shall be payable in equal monthly installments over the twelve (12)
month period commencing December 1, 2008. Subject to material improvements in Tenant's financial condition on or before the end
of October, 2008, as determined by Landlord in its sole and absolute discretion, Landlord may elect to allow Tenant to delay repayment
of those deferred amounts, including interest thereon, during the month of November as well, such that 50% of the deferrals, plus
interest, would be due December 1, 2008 and the balance, plus interest, due in equal monthly installments during calendar 2009.

 

		III.	In consideration for the deferral outlined in Section II above, Landlord and Tenant hereby agree
to terminate Tenant's Lease as it relates to that 4,537 rentable square foot portion of the Premises defined as the “Additional
Space” in the Revised Third Amendment (the “Third Amendment Additional Space”); such termination to be effective
October 31, 2008. The Rentable Area of the Premises, Tenant's Parking and Tenant's Pro-Rata Share will be adjusted to reflect the
deletion from the Premises of the Third Amendment Additional Space and the Rent shall be adjusted to reflect the subtraction of
the applicable Rent amounts specified for said Third Amendment Additional Space in Section V of the revised Third Amendment. After
October 31, 2008 Tenant shall have hold-over rights to the Third Amendment Additional Space per the terms of Article 13 of the
Lease, except that the Rent applicable thereto shall be 100%, not 150%, of the Rent specified in the Revised Third Amendment.

 

    	 

    	 

    

 

		IV.	If, prior to November 30, 2008, Tenant:

 

a)Has held over in the Third
Amendment Additional Space after the October 31, 2008 expiry thereof, per the terms relating to holdover described in Section II
above, and

 

b)has timely paid all Monthly
Base Rent and other amounts due to Landlord as required by the Lease including full repayment, with interest, of any and all deferrals
referenced in Section II above; and

 

c)has supplied to Landlord
evidence, in Landlord's reasonable opinion, of having successfully raised at least $2.5 million of new, unrestricted cash for operations.

 

Then Tenant shall have the option
to extend its lease of the Third Amendment Additional Space per the terms of the Revised Third Amendment, as if the expiry date
thereof had not been changed per Section III above. Tenant must invoke this extension option in writing to Landlord on or before
November 30, 2008.

 

		VII.	Tenant hereby represents to Landlord that it has represented itself in this transaction and that no brokerage commission will
be payable to any Tenant broker or representative as a result hereof.

 

		XII.	Except for those terms outlined herein, all other terms and conditions of the Lease and Work Letter shall apply.

 

In witness hereof, the parties have executed this Fifth Amendment
as of the date noted below.

 

	TENANT:	 	LANDLORD:
	 	 	 
	KineMed, Inc., a Delaware Corporation	 	Emery Station Office II LLC, a 
	 	 	California Limited Liability Company
	 	 	 	 	 
	By:	/s/ David M. Fineman	 	By:	/s/ Richard K. Robbins

 

	Print Name:	David M. Fineman	 	Print Name:	Richard K. Robbins

 

	Its:	President	 	Its: 	Managing member
	 	 	 	 	 
	Dated: 9/15/08	 	Dated: 9/24/08

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