Document:

Prepared by R.R. Donnelley Financial -- Sublease Agreement dated June 24, 2002

 EXHIBIT 10.6A 
  
 SUBLEASE 
  
 651 GATEWAY BOULEVARD 
 (SUITE 950)

  
 SOUTH SAN FRANCISCO, CALIFORNIA 
  
 ELAN PHARMACEUTICALS, INC. 
 a Delaware corporation as Sublessor 
  
 and 
  
 TERCICA MEDICA, INC. 
 a Delaware corporation 
  
 as Sublessee 

 BASIC SUBLEASE INFORMATION 
  
 DEFINED TERMS 
  

	 Building:
	  	 651 Gateway Boulevard
 South San Francisco,
California 94080

		
	 Effective Date:
	  	June 24, 2002
		
	 Commencement Date:
	  	The date following the Effective Date which is the later of (i) the date upon Sublessor has tendered possession of the Premises to Sublessee, or (ii) the date upon which Sublessor
hag obtained Master Landlord’s consent to this Sublease, subject to the terms and conditions of Section 17.3 hereof.
		
	Rent Commencement
Date:	  	The later of (i) July 1, 2002 or (ii) the Commencement Date.
		
	 Master Landlord:
	  	Gateway Center, LLC, a California limited liability company, successor in interest to HMS Office, L.P., a Delaware limited partnership
		
	Master Landlord’s
Address for Notice:	  	 Boston Properties
 Four Embarcadero Center,
Lobby Level, Suite One
 San Francisco, CA 94111-5994
 Phone: 415
772-0700
 Fax: 415 982-1780
 Attn: Peter Victor, Vice President,
Office Leasing

		
	 Master Lease:
	  	That certain Office Building Lease by and between HMS Office, L.P., and Sublessor, dated as of June 1, 1999 (the “Original Lease”), as amended by that certain First
Amendment to Lease between Gateway Center, LLC and Sublessor, dated as of October 25, 1999 (the “Amendment”), true and complete copies of which are attached hereto and incorporated herein as Exhibit A.
		
	 Master Premises:
	  	Suite 950 and Suite 980 of the building located at 651 Gateway Boulevard, South San Francisco, California and the entire eighth (8th) floor of the building located at 601 Gateway
Boulevard, South San Francisco, California
		
	 Premises:
	  	Improved real property consisting of Suite 950 of the building located at 651 Gateway Boulevard, South San Francisco, California, as more particularly described in the Master Lease,
consisting of a portion of the Master Premises, containing approximately 7,490 rentable square feet as

	 	  	depicted on Exhibit B attached hereto and incorporated herein, and a nonexclusive right to utilize all of Sublessor’s leasehold interest in the Common
Areas (as defined in Section 1 of the Master Lease).
			
	Monthly Base Rent:	  	Dates	  	Monthly Rent
	 	  	7/1/02-6/30/03	  	$14,814.00
	 	  	7/1/03-6/30/04	  	$14,814.00
	 	  	7/1/04-12/14/04	  	$14,814.00
		
	Security Deposit:	  	$14,814.00
		
	Sublessee:	  	Tercica Medica, Inc., a Delaware corporation
		
	Sublessee’s Address for
Notice:	  	 Before the Rent Commencement Date:
 303 Twin Dolphin Drive Suite 600
 Redwood City, CA 94065
 Attn: Howard Moore

		
	 	  	After the Commencement Date: At the Premises
		
	Sublessee’s Proportionate
Share:	  	Seventy-Sixty Percent (76%) of Additional Rent for the Existing Premises (as defined in Section 4.2 of the Original Lease and excluding any Operating Expenses in
connection with the Expansion Premises) (See Section 3.2 below) and Sublessee Taxes (as defined in Section 3.2 of this Sublease).
		
	Sublessor:	  	Elan Pharmaceuticals, Inc., a Delaware corporation
		
	Sublessor’s Address for
Rent and Notice:	  	 7475 Lusk Boulevard
 San
Diego, CA 92121
 Attn: Rick Smith

		
	Term:	  	The term (“Tern”) of this Sublease shall begin on the Commencement Date and expire on December 14, 2004. Notwithstanding the foregoing, the Tenant shall
cease upon, and shall not refer to any period of time after, termination of the Master Lease (whether pursuant to the terms of the Master Lease, by operation of law, or otherwise).
		
	Permitted Uses:	  	The Uses set forth in Section 7 of the Master Lease.
		
	Brokers:	  	 CB Richard Ellis, Inc. for Sublessor
 BT Commercial for Sublessee

		
	Exhibits:	  	Exhibit A - Master Lease

  

 -ii- 

	 Exhibit B – Premises Depiction

	 Exhibit C – Personal Property Inventory

	 Exhibit D – Paint and Carpet Specifications

	 Exhibit E – PBX Switching System

  

 -iii- 

 TABLE OF CONTENTS 
  

	 	  	 	  	 	  	 	  	Page

	 ARTICLE 1 – PREMISES
	  	1
				
	 	  	1.1	  	Demise of Premises	  	1
	 	  	1.2	  	Condition of Premises	  	2
	 	  	 	  	1.2.1	  	Physical Condition	  	2
	 	  	 	  	1.2.2	  	Certain Improvements	  	2
	 	  	 	  	1.2.3	  	No Representations	  	2
	 	  	1.3	  	Validity of Master Tease	  	3
		
	 ARTICLE 2 – TERM
	  	3
		
	 ARTICLE 3 – SUBLESSEE’S PAYMENT OBLIGATIONS
	  	3
				
	 	  	3.1	  	Monthly Rage Rent	  	3
	 	  	3.2	  	Additional Rent	  	3
	 	  	3.3	  	Security Deposit	  	4
		
	 ARTICLE 4 – USE OF ADDITIONAL
	  	4
		
	 ARTICLE 5 – USE
	  	5
		
	 ARTICLE 6 – RIGHTS AND DUTIES OF SUBLESSEE
	  	5
				
	 	  	6.1	  	Sublease Subject to Master Lease	  	5
	 	  	6.2	  	Exclusions	  	6
	 	  	6.3	  	Time for Notice	  	6
	 	  	6.4	  	Sublessor’s Obligations	  	6
	 	  	6.5	  	Use of Building Common Areas	  	7
	 	  	6.6	  	Entry by Sublessor	  	7
		
	 ARTICLE 7 – LEASE AND PURCHASE OF PERSONAL, PROPERTY; LEASE OF PHONE
SYSTEM
	  	7
		
	 ARTICLE 8 – INDEMNIFICATION
	  	7
		
	 ARTICLE 9 – INSURANCE
	  	8
		
	 ARTICLE 10 – DEFAULTS AND REMEDIES
	  	8
		
	 ARTICLE 11 – NOTICES
	  	8
		
	 ARTICLE 12 – ASSIGNMENT AND SUBLETTING
	  	8
		
	 ARTICLE 13 – REPAIRS AND MAINTENANCE
	  	8
		
	 ARTICLE 14 – DAMAGE AND DESTRUCTION
	  	9
				
	 	  	14.1	  	Termination of Master Lease	  	9
		
	 ARTICLE 15 – SURRENDER OF PREMISES
	  	9

  

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	 ARTICLE 16 – RIGHT OF FIRST OFFER
	  	10
				
	 	  	16.1	  	Right of First Offer	  	10
	 	  	16.2	  	Procedure	  	10
		
	 ARTICLE 17 – MISCELLANEOUS
	  	10
				
	 	  	17.1	  	Entire Agreement	  	10
	 	  	17.2	  	Captions	  	11
	 	  	17.3	  	Master Landlord’s Consent	  	11
	 	  	17.4	  	Authority	  	11
	 	  	17.5	  	Attorney Fees	  	11
	 	  	17.6	  	Broker	  	11
	 	  	17.7	  	Counterparts	  	11
	 	  	17.8	  	Severability	  	12
	 	  	17.9	  	Governing Law	  	12
	 	  	17.10	  	Negotiated Transaction	  	12

  

 -v- 

 SUBLEASE AGREEMENT 
  
 THIS SUBLEASE AGREEMENT (“Sublease”) is entered as of the Effective Date by and between Sublessor and
Sublessee. 
  
 THE PARTIES ENTER this Sublease on the basis
of the following facts, understandings and intentions: 
  
 A.
Master Landlord is the current Landlord of the Premises. Sublessor is presently the Tenant of the Premises pursuant to the Master Lease. A copy of the Master Lease with all amendments, exhibits and addenda thereto, is attached hereto as Exhibit
A and incorporated herein by this reference. 
  
 B. Sublessor
desires to sublease the Premises to Sublessee and Sublessee desires to sublease the Premises from Sublessor on all of the terms, covenants and conditions set forth herein. 
  
 C. All of the terms and definitions of the Basic Sublease Information of this Sublease are incorporated herein by this
reference. Unless otherwise defined herein or the context otherwise requires, all capitalized terms shall have the meanings given them in the Master Lease. 
  
 NOW, THEREFORE, IN CONSIDERATION of the mutual covenants and promises of the parties, the parties hereto agree as follows: 
  
 ARTICLE 1—PREMISES 
  
 1.1 Demise of Premises. Sublessor hereby subleases to Sublessee
and Sublessee hereby subleases from Sublessor the Premises, for the Term and upon all of the terms and conditions herein set forth. The Premises shall be used by Sublessee for those uses specifically set forth in the Basic Sublease Information,
subject to the terms and conditions of the Master Lease, including Section 7 of the Master Lease. In addition, Sublessor shall lease to Sublessee, and Sublessee shall lease from Sublessor, the PBX switching system, on the Premises as further
described on Exhibit E hereto (the “PBX Switching System”), the personal property set forth on Exhibit C hereto (the “Exhibit C Property’), the computer racks currently on the Premises and the UPS battery back-up
system currently on the Premises and any and all permanent improvements in or on the Premises (all of the foregoing collectively, the “Improvements”) constructed and/or owned by Master Landlord and/or Sublessor upon all of the terms,
covenants and conditions herein contained. As used herein, “Premises” shall include the Premises and the Improvements. The Premises represents sixty percent (76%) of the total space in the Existing Premises, which shall be Sublessee’s
“Proportionate Share” of Additional Rent (as defined in the Basic Sublease Information). It is understood that Sublessee shall have the right to occupy the Premises on the Commencement Date for the operation of its business, provided that
Sublessee recognizes that Sublessor shall simultaneously be performing the Sublessee Improvements therein and Sublessee shall cooperate to change offices to accommodate and not in any manner hinder completion of the Sublessee Improvements and shall
be subject to noise and vapors arising out of the normal course of completion of such Sublessee Improvements. 

 1.2 Condition of Premises. 
  
 1.2.1 Physical Condition. Except as otherwise expressly set forth herein, Sublessor will deliver the Premises
to Sublessee in its current “as-is” condition as of the Effective Date. As of the Effective Date, Sublessee acknowledges that Sublessee has conducted Sublessee’s own investigation of the Premises and the physical condition thereof,
which in Sublessee’s judgment affect or influence Sublessee’s use of the Premises and Sublessee’s willingness to enter this Sublease and that, except as otherwise expressly set forth herein, neither Sublessor nor any of its employees
or agents have made or shall have any liability for any representations or warranties, express or implied, with respect to the condition of the Premises. Except as otherwise expressly set forth herein, by occupying the Premises on the Commencement
Date, Sublessee shall be deemed to have acknowledged that it accepts the Premises in their current condition. Sublessee agrees on the last day of the Sublease Term to surrender the Premises unto Sublessor in accordance with Article 15 of this
Sublease. 
  
 1.2.2 Certain Improvements. Subject to
receipt of any necessary consents and approvals from Master Landlord, Sublessor agrees to provide new paint and carpet for the Premises (the “Sublessee Improvements”). Sublessor shall complete the Sublessee Improvements as soon as
reasonably practical following the later of (i) Master Landlord approval of the Sublessee Improvements, (ii) the Commencement Date and (iii) receipt of the necessary materials from the supplier, provided that such deadline shall be delayed one day
for each day that completion is delayed by the acts of Sublessee or its agents (“Improvement Completion Date’). Sublessor and its agents shall have the right to enter onto the Premises and store equipment in the Premises as reasonably
necessary to provide the Sublessee Improvements. The paint and carpet shall comply with the specifications set forth on Exhibit D attached hereto and the Sublessee Improvements shall be completed in a good and workmanlike manner. Except as
set forth in the immediately preceding sentence, Sublessee agrees that Sublessor makes no representations or warranties whatsoever regarding the fitness of the Sublessee Improvements for any purpose, the quality of the Sublessee Improvements, the
freedom of the Sublessee Improvements from fault or defects or any other representation whatsoever concerning the Sublessee Improvements. Sublessor’s obligation to provide the Sublessee Improvements shall be independent of Sublessee’s
obligation to pay the Sublessee Rent. 
  
 1.2.3 No
Representations. Sublessee and Sublessor recognize and agree that Sublessor would not sublease the Premises to Sublessee and Sublessee would not sublease the Premises from Sublessor except on an “as is” basis and acknowledges that
neither Sublessee nor Sublessor has made any representations of any kind, express or implied, in connection with the Improvements or physical conditions on, or bearing on, the Premises, including without limitation the suitability of the Premises
for Sublessee’s purposes. Sublessee further recognizes and agrees that neither Sublessor nor Master Landlord shall be required to perform any work of construction, alteration or maintenance of or to the Premises except as set forth herein.
Notwithstanding the foregoing, Sublessee shall not be required to construct or pay the cost of complying with any covenants, conditions, restrictions, encumbrances, rules, regulations, statutes, ordinances, laws or building codes requiring
construction or improvements to any alterations, improvements or additions 
  

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 to the Premises that were made by Sublessor and are properly capitalized under general accounting principles, unless such
compliance is necessitated solely because of Sublessee’s particular use of the Premises. 
  
 1.3 Validity of Master Tease. Sublessor hereby warrants that the Master Lease attached hereto as Exhibit A is complete and in full force and effect, and that Sublessor is not in material default
thereunder beyond expiration of any applicable cure or notice period, that, to the knowledge of Sublessor, (i) no other party to the Master Lease is in breach or default thereof, (ii) the area which is the subject of the Sublease has not been
previously assigned or subleased by Sublessor, and (iii) no other party has a legal right to occupy such area. 
  
 ARTICLE 2—TERM 
  
 The term of this Sublease shall be for the Term set forth in the Basic Sublease Information provided that upon full execution of this Sublease by Sublessor and Sublessee, and on or before the Commencement Date
Sublessee provides Sublessor with (i) the certificates evidencing the insurance required by Article 9 of this Sublease, (ii) the first month’s Base Rent and (iii) the Security Deposit. 
  
 ARTICLE 3—SUBLESSEE’S PAYMENT OBLIGATIONS 

 
 3.1 Monthly Rage Rent. The Monthly Base Rent shall be
payable in advance in equal monthly installments in accordance with the schedule for payment of Monthly Base Rent set forth in the Basic Sublease Information, commencing with the Rent Commencement Date. Upon the execution of this Sublease by
Sublessor and Sublessee, Sublessee shall deposit with Sublessor prepaid Rent in an amount equal to Fourteen Thousand Eight Hundred Fourteen Dollars ($14,814.00) for the first month’s Base Rent (“Prepaid Rent”). Sublessee shall
thereafter pay to Sublessor the Monthly Base Rent in advance, on or before the first day of each month, beginning on the first day of the calendar month succeeding the Rent Commencement Date Base Rent and any additional rent due hereunder shall be
payable to Sublessor, without further notice or demand and without deduction or offset, in lawful money of the United States of America at the address specified in the Basic Sublease Information or at such other address as Sublessor may from time to
time designate in writing. If the Term shall end on a day other than the last day-of a calendar month, then Rent for the last month of the Term shall be prorated on a per diem basis, with respect to the portions of the last fractional calendar month
included in the Term. 
  
 3.2 Additional Rent. In
addition to Monthly Base Rent, Sublessee shall be responsible for (a) Sublessee’s Proportionate Share of the Additional Rent (as set forth in the Basic Sublease Information), it being the intent of the parties hereto that, Sublessee shall owe
no Operating Expenses (as defined in the Master Lease) to Sublessor applicable to calendar year 2002, (b) Sublessee Taxes (as defined below) and (c) all other additional rent which may be imposed, at any time, on Sublessor with respect to the
Premises pursuant to the Master Lease; provided that Sublessee shall not be responsible for any penalties, interest or other costs incurred by Sublessor under the Master Lease that are caused by (i) Sublessor’s failure to pay rent to Master
Landlord in a timely manner in accordance with the Master Lease, unless such failure is cause by Sublessee’s default or failure to make timely payments to Sublessor in accordance with this Sublease, or (ii) a 
  

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 breach of the Master Lease or Sublease by, or the acts or negligence of Sublessor or its agents, representatives,
sublessees, employees or invitees (except to the extent such breach, negligence or acts were caused by Sublessee or its agents, representatives, sublessees, employees or invitees). As used herein, “Sublease Rent” shall include Base Rent,
Sublessee’s Proportionate Share of Additional Rent, Sublessee Taxes and all other amounts payable by Sublessee to Sublessor hereunder. Sublessee shall be responsible for the Sublessee Rent for each and every month of the Sublease Term
commencing with the Rent Commencement Date. Sublessee shall pay its Proportionate Share of Additional Rent and Sublessee Taxes no later than thirty (30) days following Sublessee’s receipt of written demand therefor. 
  
 “Sublessee Taxes” shall consist of all taxes, fees or charges
levied or assessed against or attributable to any personal property or trade fixtures in the Premises or by reason of leasehold improvements. If any such taxes, fees or charges are included in Sublessor’s or Master Landlord’s taxes,
Sublessor may pay them regardless of the validity (under proper protest, if requested by Sublessee and at Sublessee’s sole cost and expense), and Sublessee will pay Sublessor the amount of Sublessor’s or Master Landlord’s taxes, as
applicable, attributable to Sublessee, as determined in good faith by Sublessor. 
  
 3.3 Security Deposit. Upon the execution of this Sublease by Sublessor and Sublessee, Sublessee shall pay to Sublessor the Security Deposit set forth on the Basic Sublease Information. Sublessor may (but
shall not be required to) use the Security Deposit or any portion thereof to cure any defaults on the part of Sublessee (beyond any applicable cure period) or to reasonably compensate Sublessor for any damage Sublessor incurs as a result of
Sublessee’s failure to perform any of its covenants or obligations hereunder (provided Sublessee has been given any required notice and opportunity to cure such failure as set forth under the terms of this Sublease), it being understood that
any use of the Security Deposit shall not constitute a bar or defense to any of Sublessor’s remedies under this Sublease, at law or in equity. In such event, and upon written notice from Sublessor to Sublessee specifying the amount of the
Security Deposit so utilized by Sublessor and the particular purpose for which such amount was applied, Sublessee shall immediately deposit with Sublessor an amount sufficient to return the Security Deposit to the amount specified in the Basic
Sublease Information. Upon termination or earlier expiration of this Sublease, the Security Deposit shall be returned to Sublessee, reduced by those amounts that may be required by Sublessor to remedy defaults on the part of Sublessee in the payment
of Sublessee Rent, to repair damage to the Premises and to clean the Premises to a broom-clean condition. Sublessor shall hold the Security Deposit for the foregoing purposes; provided, however, that Sublessor shall have no obligation to segregate
the Security Deposit from its general funds or to pay interest thereon. 
  
 ARTICLE 4—USE OF ADDITIONAL CONFERENCE ROOM 
  
 Sublessee shall have access to and the right to use the conference room in the Suite 980 Space (the “Conference Room”) on the terms and conditions stated herein at no additional cost and expense to Sublessee, other than the
Sublessee Rent, commencing on the Commencement Date and ending on the earlier of the following: (i) the commencement of the term of a sublease between Sublessor and Sublessee for the Suite 980 Space, (ii) the commencement of the term of a sublease
by 
  

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 a third party other than Sublessor for the Suite 980 Space, (iii) receipt of notice by Sublessee from Sublessor that
Sublessee is in breach of any of the material terms of this Sublease, or the Master Lease as incorporated herein by reference, beyond any applicable cure period, such breach to be determined in Sublessor’s reasonable discretion or (iv) the
termination of this Sublease. Sublessor’s use of the Suite 980 Space is limited to use of the Conference Room for meetings. Sublessor shall have no right of access to or right to use other portions of the Suite 980 Space and shall have no right
to use the Conference Room for any other purpose, including, but not limited to, office use and storage. Sublessee agrees to be responsible for any damage or liability which may arise in connection with its use of the Conference Room and to obtain
and maintain insurance to cover any such damage or liability on the same terms and conditions as the insurance required in Article 9 of this Sublease. Notwithstanding the foregoing, Sublessor shall have access to and the right to enter the
Conference Room at any time without prior notice to Sublessee for any purpose whatsoever, including, but not limited to, touring or inspecting the Conference Room. 
  
 ARTICLE 5—USE 
  
 The Premises are to be used for the Permitted Uses, and for no other purpose or business without the prior written consent of Sublessor. In no event shall
the Premises be used for a purpose or use prohibited by the Master Lease. 
  
 ARTICLE 6—RIGHTS AND DUTIES OF SUBLESSEE 
  
 6.1 Sublease Subject to Master Lease. It is expressly understood, acknowledged and agreed by Sublessee that this Sublease shall incorporate by reference the terms, conditions and covenants of the Master
Lease, except as excluded in Section 6.2 below, modified as appropriate in the circumstances so as to make such Sections applicable only to the subleasing hereunder by Sublessor of the Premises during the Term of this Sublease. Sublessee shall be
subject to, bound by and comply with all of said Sections of the Master Lease with respect to the Premises accruing during the Term of this Sublease, and shall satisfy all such terms and conditions of the Master Lease for the benefit of both
Sublessor and Master Landlord, it being understood and agreed that wherever in the Master Lease the Word “Tenant” appears, for the purposes of this Sublease, the word “Sublessee” shall be substituted (subject to the limitations
set forth in this Sublease), wherever in the Master Lease the word “Landlord” appears, for the purposes of this Sublease, the words “Master Landlord” (and, as applicable hereunder, “Sublessor”) shall be substituted; and
wherever in the Master Lease the word “Premises” appears, for the purposes of this Sublease, the words “Master Premises” shall be substituted; and that upon the breach of any of said terms, conditions or covenants of the Master
Lease by Sublessee or upon the failure of Sublessee to pay the Sublease Rent or comply with any of the provisions of this Sublease, Sublessor may exercise any and all rights and remedies granted to Master Landlord by the Master Lease. Sublessee
expressly acknowledges, notwithstanding anything to the contrary in this Sublease, that Sublessor’s duty to indemnify, defend and hold Sublessor harmless from and against any and, all fines, suits, losses, costs; expenses, liabilities, claims,
demands, actions, damages and judgments pursuant to this Sublease, and as more specifically set forth in Section 14 of the Master Lease, shall include Sublessor’s duty to indemnify, defend, protect and hold Master Landlord harmless from and
against 
  

 -5- 

 any and all fines, suits, losses, costs, expenses, liabilities, claims, demands, actions, damages and judgments.

  
 It is further understood and agreed that Sublessor has no duty
or obligation to Sublessee under the aforesaid Sections of the Master Lease other than to maintain the Master Lease in full force and effect during the term of this Sublease and to pay the difference between the Sublease Rent and the rent due and
payable under the Master Lease; provided, however, that Sublessor shall not be liable to Sublessee for any earlier termination of the Master Lease which is not due to the fault of Sublessor. In the event of any conflict between this Sublease and the
Master Lease, the Sublease shall control, as between Sublessor and Sublessee. Whenever the provisions of the Master Lease incorporated as provisions of this Sublease require the written consent of Landlord or notice to Landlord, said provisions
shall be construed to require the written consent and/or notice of both Master Landlord and Sublessor. Sublessee hereby acknowledges that it has read and is familiar with all the terms of the Master Lease, and agrees that this Sublease is
subordinate and subject to the Master Lease and that any termination thereof without the fault of Sublessor shall likewise terminate this Sublease. 
  
 6.2 Exclusions. The terms and provisions of the following Sections of the Original Lease are not incorporated into this Sublease: The first
and second paragraphs of Section 2; Sections 3 through 5, 8, 9(a), 10.1(b), 14, 24.1, the second sentence of Section 26.7 and the third paragraph of Section 10.2. The terms and provisions of the following Sections of the Amendment are not
incorporated into this Sublease: Sections 1.2, 2.2, and 3 through 8. 
  
 6.3 Time for Notice. The time limits provided for in the provisions of the Master Lease for the giving of notice, making of demands, performance of any act, condition or covenant, or the exercise of any right, remedy or
option, are amended for the purposes of this Sublease by lengthening or shortening the same in each instance by five (5) days, as appropriate, so that notices may be given, demands made, or any act, condition or covenant performed, or any right,
remedy or option hereunder exercised, by Sublessor or Sublessee, as the case may be, within the time limit relating thereto contained in the Master Lease. If the Master Lease allows only five (5) days or less for Sublessor to perform any act, or to
undertake to perform such act, or to correct any failure relating to the Premises or this Sublease, then Sublessee shall nevertheless be allowed three (3) days to perform such act, undertake such act and/or correct such failure. 
  
 6.4 Sublessor’s Obligations. It shall be the obligation of
Master Landlord (i) to provide or cause to be provided all services to be provided by Landlord under the terms of the Master Lease and (ii) to satisfy all obligations and covenants of Master Landlord made in the Master Lease. Sublessee acknowledges
that Sublessor shall be under no obligation to provide any such services or satisfy any such obligations or covenants; provided, however, Sublessor, upon written notice by Sublessee, shall attempt to enforce all obligations of Master Landlord under
the Master Lease, provided that Sublessee reimburses Sublessor for all reasonable costs and expenses incurred in connection therewith (except as otherwise set forth in Section 1.2.3 hereof). Sublessor shall not amend, terminate or waive any
provisions under the Master Lease or make any elections, exercise any right or remedy or give any consent or approval under the Master Lease that could result in a 
  

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 substantial interference with Sublessee’s use of the Premises or materially increase Sublessee’s obligations or
decrease Sublessee’s rights under this Sublease without, in each instance, Sublessee’s prior written consent. 
  
 6.5 Use of Building Common Areas. Sublessee shall comply with all reasonable and nondiscriminatory rules and regulations established by
Sublessor with respect to use of the Common Areas, and shall insure compliance therewith by all of Sublessee’s employees, contractors and invitees. 
  
 6.6 Entry by Sublessor. Upon forty-eight (48) hours advance verbal or written notice (except in case of emergency where no such notice shall
be required), Sublessor shall have the right to enter upon the Premises for purposes of maintenance and repair, and to ensure compliance by Sublessee with its obligations pursuant to this Sublease. Sublessee shall provide Sublessor with two keys
(including card keys, if applicable) to all doors of the Premises in order to facilitate such entry. 
  
 ARTICLE 7—LEASE AND PURCHASE OF PERSONAL, PROPERTY; 
 LEASE OF
PHONE SYSTEM 
  
 During the Term, Sublessee shall have the
right, at no additional cost and expense to Sublessee, other than payment of the Sublessee Rent, to use the PBX Switching System, the computer racks currently on the Premises, the UPS battery back-up system currently on the Premises and Exhibit C
Property. Maintenance and operation of the PBX Switching System will be the responsibility of Sublessee. Sublessee agrees to obtain and keep in effect during the Term, a maintenance agreement with an outside service provider to ensure maintenance of
the PBX System. On the last day of the Term of this Sublease, Sublessee shall be entitled to purchase the Exhibit C Property, free and clear of all liens and encumbrances, by delivering $1.00 to Sublessor. Simultaneously to delivery of such payment,
Sublessor shall execute and deliver to Sublessee a simple Bill of Sale to Sublessee warranting that the Exhibit C Property is being provided to Sublessee free and clear of all liens and encumbrances. Upon purchase, the Exhibit C Property shall be
owned by Sublessee and Sublessee shall be responsible for removing the Exhibit C Property from the Premises in accordance with Article 15 hereof. 
  
 ARTICLE 8—INDEMNIFICATION 
  
 Except to the extent resulting from the acts, negligence or breach of this Sublease or the Master Lease by Sublessor (where such breach is not caused by
Sublessee), Sublessee covenants to indemnify, defend, protect and hold Sublessor, its agents, officers, employees, and contractors harmless from and against (i) any and all claims, causes of action, obligations, liabilities, costs and expenses
(including reasonable attorneys’ fees and costs) to the extent arising out of or in connection with Sublessee’s use or occupancy of the Premises, the Conference Room and the Common Areas before or after the commencement of the Term of this
Sublease, and (ii) the breach of this Sublease (or, to the extent incorporated herein, the Master Lease) by Sublessee, its employees, agents, contractors or invitees. Sublessee’s obligations under this Article 8 shall survive the termination or
earlier expiration of this Sublease. 
  

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 ARTICLE 9—INSURANCE 
  
 Sublessee covenants to obtain and maintain the insurance policies required to be maintained by Sublessor under Section 15 of
the Master Lease naming Sublessor as an additional insured; to provide Sublessor with certificates evidencing such insurance; and not to merit cancellation or termination of such required insurance policies without giving at least fifteen (15) days
prior written notice to Sublessor and Master Landlord. Sublessee shall deliver to Sublessor, from time to time and upon Sublessor’s or Master Landlord’s reasonable written request, certificates of insurance indicating that the required
policies of insurance are in full force and effect throughout the entire term of this Sublease. All insurance policies required to be carried by Sublessor pursuant to the Master Lease shall be carried by Sublessee, covering Sublessee’s
liability, and all such policies shall be written in accordance with the requirements for such insurance set forth in Section 15 of the Master Lease. 
  
 ARTICLE 10—DEFAULTS AND REMEDIES 
  
 In the event of a default by Sublessee, Sublessor shall have all of the rights and remedies against Sublessee as are set forth in Section 19 of the Master
Lease as though Sublessor were the landlord named therein and Sublessee was the tenant named therein. 
  
 ARTICLE 11—NOTICES 
  
 All notices or correspondence provided for herein shall be in writing and shall be sent by certified mail, postage prepaid, return receipt requested, or by a nationally-recognized overnight delivery company which
provides a receipt evidencing delivery, in which event they shall be deemed received on the date of delivery as evidenced by the receipt. The Master Landlord’s, Sublessor’s and Sublessee’s addresses for written notices required to be
given hereunder shall be the addresses set forth in the Basic Sublease Information, or at such other place designated by advance written notice delivered in accordance with the foregoing. 
  
 ARTICLE 12—ASSIGNMENT AND SUBLETTING 
  
 Sublessee shall not sell, assign, encumber, sublet, hypothecate or otherwise transfer by operation of law or otherwise this
Sublease or the Sublessor’s interest in and to the Premises except in accordance with Section 20 of the Master Lease as modified by this Sublease. 
  
 ARTICLE 13—REPAIRS AND MAINTENANCE 
  
 Except to the extent constituting an obligation of the Master Landlord under the Master Lease, Sublessee shall, at Sublessee’s sole expense, keep the
Premises in good order and sanitary condition, and repair any damage thereto caused by Sublessee or Sublessee’s agents, employees, contractors or invitees. In performing its obligations under this Article 13, Sublessee shall notify Sublessor
and of any repairs that could affect the Systems serving the Building (exclusive of the Premises) and shall use contractors approved by Master Landlord, in its reasonable discretion. Sublessee acknowledges that, except as otherwise expressly
provided herein, Sublessor is under no 
  

 -8- 

 duty to make repairs or improvements to the Premises, and Sublessee hereby waives any right it may have at law or in
equity to enforce the same. Notwithstanding the foregoing, to the extent Master Landlord is obligated under the Master Lease to make any maintenance or repairs in or to the Premises, Sublessor, upon written notice by Sublessee, shall attempt to
enforce such obligations of Master Landlord, provided that (except as provided in Section 1.2.3 hereof) Sublessee reimburses Sublessor for all reasonable costs and expenses incurred in connection therewith. Notwithstanding the foregoing, if such
maintenance or repairs affect the use and enjoyment of the Common Area, such costs and expenses of enforcement shall be paid by Sublessor and Sublessee in proportion to their relative interests in the Master Premises. 
  
 ARTICLE 14—DAMAGE AND DESTRUCTION 
  
 14.1 Termination of Master Lease. If the Premises is damaged or
destroyed and Master Landlord, Sublessor or Sublessee validly exercises any option to terminate the Master Lease or this Sublease as specifically provided for in the Master Lease or this Sublease (or in the Master Lease as incorporated herein by
reference), if any, this Sublease shall terminate as of the date of the termination of the Sublease by either party hereto or the date of the termination of the Master Lease. 
  
 14.2 Continuation of Sublease. If the Master Lease is not terminated following any damage or destruction as
provided above, this Sublease shall remain in full force and effect. Sublessee shall be’ obligated to fulfill any repair obligations of Sublessor with respect to the Premises; provided, however, that (i) Sublessor shall use commercially
reasonable means to enforce any obligation of Master Landlord to rebuild the Premises in accordance with the Master Lease; (ii) Sublessor shall make available to Sublessee any insurance proceeds Sublessor receives as a result of damage or
destruction of the Premises; and (iii) Sublessee shall be entitled to abatement of Sublessee Rent on a proportionate basis (based on the degree to which Sublessee’s use of the Premises is impaired as compared to the impairment of
Sublessor’s use of the Master Premises) to the extent that Sublessor’s Rent is abated under the Master Lease. In the event that the damage cannot reasonably be repaired by the date that is 90 days prior to the expiration of the Term of
this Sublease, then either party may terminate this Sublease by written notice to the other party. Notwithstanding anything to the contrary contained herein, if such damage or destruction occurs and the Premises can not be, or is in fact not,
restored so that such damage or destruction does not unreasonably interfere with Sublessee’s normal business operations within 180 days following the date of such damage or destruction, Sublessee shall have the right to terminate this Sublease
immediately upon deliver of written notice to Sublessor. 
  
 ARTICLE 15—SURRENDER OF PREMISES 
  
 Sublessee shall peaceably surrender the Premises to Sublessor upon expiration or earlier termination of this Sublease, broom-clean and in as good a condition as when Sublessee took possession and Sublessee shall remove Sublessee’s
personal property and any or all Alterations made by Subtenant (not including the Sublessee Improvements, which shall remain on the Premises, and provided that Master Landlord or Sublessor so notified Sublessee in accordance with Section 10.2 of the
Lease), upon the expiration or earlier termination of this Sublease and promptly repair all damage to the Premises caused by such removal. Unless Master Landlord or Sublessor 
  

 -9- 

 requires their removal, all Alterations made to the Premises by Sublessee shall remain upon and be surrendered with the
Premises at the expiration or earlier termination of this Sublease. 
  
 If Sublessee abandons the Premises, any of Sublessee’s personal property left on the Premises shall be deemed to be abandoned, and, at Sublessor’s option, title shall pass to Sublessor under this Sublease as by a bill of sale. If
Sublessee abandons the Premises and Sublessor elects to remove all or any part of Sublessee’s personal property, the reasonable cost of removal, including repairing any damage to the Premises or Building caused by such removal, shall be paid by
Sublessee. The provisions of this Article 15 shall survive the expiration or earlier termination of this Lease. 
  
 ARTICLE 16—RIGHT OF FIRST OFFER 
  
 16.1 Right of First Offer. Sublessor hereby grants to Sublessee a right of first offer (the “Sublessee Right of First Offer”) with
respect to approximately 2,411 rentable square feet in Suite 980 of the building located at 651 Gateway Boulevard, South San Francisco, California (the “First Offer Space”) on the terns and conditions set forth herein. 
  
 16.2 Procedure. Prior to entering into any sublease with a
third party for the First Offer Space, Sublessor shall provide written notice to Sublessee of such third party’s offer to sublease the First Offer Space (the “Third Party Offer”), including the general terms and conditions of the
Third Party Offer. Sublessee shall have three (3) days from receipt of such notice in which to notify Sublessor in writing of its intent to exercise the Sublessee Right of First Offer (the “Exercise Notice”), which exercise must be on
terns and conditions no less favorable to Sublessor than the Third Party Offer. 
  
 For thirty (30) days following Sublessor’s receipt of Sublessee’s Exercise Notice (the “Exclusivity Period”), Sublessor and Sublessee shall negotiate in good faith the terns of a sublease to
Sublessee for the First Offer Space, which shall be substantially on the same terns and conditions of this Sublease (as modified by the Third Party Offer). During the Exclusivity Period, Sublessor shall not enter into a sublease of the First Offer
Space with anyone other than Sublessee. In the event that Sublessor and Sublessee, despite good faith negotiations, do not enter into a sublease for Sublessee of the First Offer Space or are unable to obtain consent from the Master Landlord to such
sublease before the end of the Exclusivity Period, then Sublessor shall have the right to enter into a sublease on terms and conditions materially no more favorable to a sublessee than those contained in the original Third Party Offer with any other
party. In the event that Sublessor proposes to sublease the Premises on terms and conditions materially more favorable to a sublessee than those contained in the original Third Party Offer, then such terms and conditions shall constitute a new Third
Party Offer subject to a new Exercise Notice by Sublessee. 
  
 ARTICLE 17—MISCELLANEOUS 
  
 17.1
Entire Agreement. This Sublease and the applicable portions of the Master Lease contained by reference herein, contain all of the covenants, conditions and agreements between the parties concerning the Premises, and shall supersede any
and all prior correspondence, agreements 
  

 -10- 

 and understandings concerning the Premises, both oral and written. No addition or modification of any tern or provision
of this Sublease shall be effective unless set forth in writing and signed by both Sublessor and Sublessee. 
  
 17.2 Captions. All captions and headings in this Sublease are for the purposes of reference and convenience and shall not limit or expand
the provisions of this Sublease. 
  
 17.3 Master
Landlord’s Consent. This Sublease is conditioned upon Master Landlord’s written approval of this Sublease prior to the Commencement Date. If Master Landlord refuses to consent to this Sublease, then this Sublease shall be deemed
void and of no effect, in which event the parties shall be discharged from all obligations hereunder and Sublessor shall return the Prepaid Rent, if previously delivered to Sublessor, to Sublessee. If Master Landlord does not provide consent to this
Sublease on or before June 30, 2002 in a form of consent acceptable to Sublessee and Sublessor, each in its sole discretion, or if Sublessor is unable to tender possession of the Premises to Sublessee on or before June 30, 2002 (through no fault of
Sublessor), then either party may by written notice delivered to the other party no later than five (5) days following such date have the right to terminate this Sublease, in which event the parties shall be discharged from all obligations hereunder
and Sublessor shall return the Prepaid Rent, if previously delivered to Sublessor, to Sublessee. 
  
 17.4 Authority. Each person executing this Sublease on behalf of a party hereto represents and warrants that he or she is authorized and
empowered to do so and to thereby bind the party on whose behalf he or she is signing. 
  
 17.5 Attorney Fees. In the event either party shall bring any action or proceeding for damages or for an alleged breach of any provision of this Sublease to recover rents, or to enforce, protect or
establish any right or remedy hereunder, the prevailing party shall be entitled to recover reasonable attorneys’ fees and court costs as part of such action or proceeding. 
  
 17.6 Broker. Sublessor shall be responsible for payment of any and all finder’s fees or commissions to CD
Richard Ellis, Inc. and BT Commercial (“Brokers”) in connection with this Sublease pursuant to a separate agreement. Each party warrants and represents that it has had no dealings with any real estate broker, agent or finder other than
Brokers in connection with the negotiation of this Sublease, and that it knows of no other real estate broker or agent who is entitled to any commission or finder’s fee in connection with the Premises or this Sublease. Each party shall
indemnify and hold the other harmless from and against any and all claims, demands, losses, liabilities, lawsuits, judgments, costs and expenses (including without limitation, attorneys’ fees and costs) arising from any claim for a leasing
commission or equivalent compensation alleged to be owing on account of the indemnifying party’s dealings with any, real estate broker or agent in connection with the Premises or this Sublease. 
  
 17.7 Counterparts. This Sublease may be executed in any number
of counterparts, each of which shall be deemed to be an original and all of which taken together shall comprise but a single instrument. 
  

 -11- 

 17.8 Severability. If any provisions of this Sublease or the application of any provision
of this Sublease to any person or circumstance is, to any extent, held to be invalid or unenforceable, the remainder of this Sublease or the application of that provision to persons or circumstances other than those as to which it is held invalid or
unenforceable, will not be affected, and each provision of this Sublease will be valid and be enforced to the fullest extent permitted by law. 
  
 17.9 Governing Law. This Sublease will be governed by and in all respects construed in accordance with the laws of the State of California,
without giving effect to any choice of law rule that would cause the application of the laws of any jurisdiction other than the State of California. 
  
 17.10 Negotiated Transaction. The parties mutually acknowledge that this Sublease has been negotiated at arm’s length. The provisions
of this Sublease shall be deemed to have been drafted by all of the parties and this Sublease shall not be interpreted or construed against any party solely by virtue of the fact that such party or its counsel was responsible for its preparation.

  
 [Remainder of This Page Intentionally Left Blank] 

 
  

 -12- 

 IN WITNESS WHEREOF, the parties hereto have executed one (1) or more copies of this Sublease,
effective as of the Effective Date. 
  

	“SUBLESSOR”
	
	 ELAN PHARMACEUTICALS, INC.
 a Delaware corporation

		
	By:	 	 /S/    ERLE
MAST        

	Name:	 	 Erle Mast

	Its:	 	 VP & Treasurer

	
	“SUBLESSEE”
	
	 TERCICA MEDICA, INC.
 a Delaware corporation

		
	By:	 	 /S/    HOWARD
MOORE        

	Name:	 	 Howard Moore

	Its:	 	 Executive Vice President

 EXHIBIT A 
  

MASTER LEASE 
  

 A-1 

 OFFICE BUILDING LEASE 
  
 by and between 
  
 HMS OFFICE, L.P., 
 a Delaware Limited Partnership 
  
 and 
  
 ELAN PHARMACEUTICALS, INC., 
 a
Delaware corporation 
  

 LEASE SUMMARY 
  

		
	 Date:
	  	June 1, 1999
		
	 Tenant:
	  	Elan Pharmaceuticals, Inc., a Delaware corporation
		
	 Address:
	  	 800 Gateway Boulevard
 South San
Francisco, California 94080
 Attn: General Counsel

		
	 	  	with copy to:
		
	 	  	 800 Gateway Boulevard
 South San
Francisco, California 94080
 Attn: Chief Financial Officer

		
	 Landlord:
	  	HMS Office, L.P.
		
	 Address:
	  	c/o Hines Interests Limited Partnership 651 Gateway Boulevard, Suite 1140 South San Francisco, California 94080
		
	 Premises:
	  	Suite 950 and Suite 980
		
	 Building:
	  	651 Gateway Boulevard South San Francisco, California 94080
		
	 Approximate Rentable
	  	 
	 Area of Premises:
	  	Nine Thousand Nine Hundred one (9,901) square feet comprised of (1) Seven Thousand Four Hundred Ninety (7,490) square feet located in Suite 950 (the “Suite 950 Space”),
and (ii) Two Thousand Four Hundred Eleven (2,411) square feet located in Suite 980 (the “Suite 980 Space”)
		
	 Approximate Rentable
	  	 
	 Area of Building:
	  	Two Hundred Ninety Thousand Four Hundred Forty-Seven (290,447) square feet
		
	 Estimated
	  	 
	 Commencement Date:
	  	July 1, 1999
		
	 Term:
	  	2 Lease Years

		
	 Base Rent:
	  	Twenty Eight Thousand Two Hundred Seventeen and 85/100ths Dollars ($28,217.85) per. month (based upon $2-85 per rentable square foot per month)
		
	 Operating Expense Base:
	  	$8.07 per square foot of Rentable Area per year
		
	 Security Deposit:
	  	Twenty-Eight Thousand Two Hundred Seventeen and 85/100ths Dollars (S28,217.85)
		
	 Use:
	  	General office use
		
	 Parking Spaces:
	  	Thirty-0ne (31)
		
	 Guarantor:
	  	Not applicable
		
	 Exhibits:
	  	A, B, C, D, L and F
		
	 Broker:
	  	Marc Pearson of Catalyst CRESA Real Estate Group, as Tenant’s representative

  
  

 -2- 

 TABLE OF CONTENTS 
  

	 	 	 	  	Page

	 1.
	 	Definitions	  	1
			
	 2.
	 	DEMISE	  	5
			
	 3.
	 	ACCEPTANCE OF PREMISES	  	7
			
	 4.
	 	RENT	  	8
				
	 	 	4.1	  	Base Rent	  	8
	 	 	4.2	  	Additional Rent	  	8
			
	 5.
	 	SECURITY DEPOSIT	  	8
			
	 6.
	 	SERVICES PROVIDED BY LANDLORD	  	9
			
	 7.
	 	USE; HAZARDOUS SUBSTANCES	  	10
				
	 	 	7.1	  	Use of Premises	  	10
	 	 	7.2	  	Hazardous Substances	  	10
			
	 8.
	 	BROKERS	  	11
			
	 9.
	 	TENANT’S TAXES	  	11
			
	 10.
	 	ALTERNATIONS, REPAIRS AND MAINTENANCE	  	12
				
	 	 	10.1	  	Repairs and Maintenance	  	12
	 	 	10.2	  	Alterations	  	13
			
	 11.
	 	LIENS	  	14
			
	 12.
	 	ENTRY	  	15
			
	 13.
	 	LANDLORD’S LIABILITY	  	15
			
	 14.
	 	INDEMNIFICATION AND EXCULPATION	  	15
			
	 15.
	 	INSURANCE	  	16
			
	 16.
	 	NO SUBROGATION	  	17
			
	 17.
	 	DAMAGE OR DESTRUCTION	  	17
				
	 	 	17.1	  	Cancellation of Lease: Restoration of Building	  	17
	 	 	17.2	  	Casually Loss During Last Year of Lease	  	18
	 	 	17.3	  	Abatement of Rent	  	18
	 	 	19.2	  	Remedies	  	20
	 	 	19.3	  	Continuing Liability	  	21
	 	 	19.4	  	Remedies Cumulative	  	22
	 	 	19.5	  	No Waiver	  	22
			
	 20.
	 	ASSIGNMENT OR SUBLEASE	  	22
				
	 	 	20.1	  	Notification	  	22
	 	 	20.2	  	Landlord Approval	  	22

  

 -i- 

				
	 	  	20.3	  	Allocation of Excess Rent	  	23
	 	  	20.4	  	Fair Market Rent	  	23
	 	  	20.5	  	No Release from Liability	  	23
	 	  	20.6	  	Compliance with Laws	  	23
	 	  	20.7	  	Reimbursement of Costs	  	24
	 	  	20.8	  	Negotiation with Assignee	  	24
	 	  	20.9	  	Change Of Control; Affiliates	  	24
	 	  	20.10	  	Conveyance by Landlord	  	24
			
	 21.
	  	SUBORDINATION	  	25
			
	 22.
	  	ESTOPPEL CERTIFICATE	  	 
			
	 23.
	  	INTENTIONALLY DELETED	  	25
			
	 24.
	  	SURRENDER OF PREMISES	  	26
				
	 	  	24.1	  	Leasehold Improvements and Fixtures	  	26
	 	  	24.2	  	Holding Over	  	26
			
	 25.
	  	PROFESSIONAL FEES	  	27
			
	 26.
	  	GENERAL PROVISIONS	  	27
				
	 	  	26.1	  	Mortgage Protection	  	27
	 	  	26.2	  	Successors and Assigns	  	27
	 	  	26.3	  	Waiver	  	27
	 	  	26.4	  	Identification of Tenant	  	28
	 	  	26.5	  	Parking	  	28
	 	  	26.6	  	Interpretation of Lease	  	28
	 	  	26.7	  	Limitation on Liability	  	29
	 	  	26.8	  	Traffic Impact	  	29
	 	  	26.9	  	Financial Statements	  	29
	 	  	26.10	  	Quiet Enjoyment	  	29
	 	  	26.11	  	Payments and Notice	  	29
	 	  	26.12	  	Late Charge	  	30
	 	  	26.13	  	Rules and Regulations	  	30
	 	  	26.14	  	Rights Reserved by Landlord	  	30
	 	  	26.15	  	Related Parties	  	31
	 	  	26.16	  	Landlord’s Costs	  	31
	 	  	26.17	  	Invoices	  	31
	 	  	26.18	  	Force Majeure; Time of Essence	  	32
	 	  	26.19	  	Negotiated Transaction	  	32
	 	  	26.20	  	Nondisturbance, Attornment and Subordination Agreement	  	32
	 	  	26.21	  	Nondiscrimination	  	32
	 	  	26.22	  	Corporate Authority	  	32
	 	  	26.23	  	Notice Pursuant to California Health do Safety Code Section 25359.7	  	33
	 	  	26.24	  	Entire Agreements; Amendments	  	33

  

 -ii- 

 THE GATEWAY 
  
 OFFICE BUILDING LEASE

  
 This Lease is made and entered into as of the date
specified in the Lease Summary attached hereto and incorporated herein by this reference, by and between HMS OFFICE, L.P. a Delaware limited partnership (“landlord”), and the Tenant identified in the Lease Summary. 
  
 In consideration of the mutual covenants and agreements contained in this
Lease, the parties agree as follows: 
  
 1. Definitions 
  
 Certain terms used in this Lease and the Exhibits hereto shall have the
meaning set forth below for each such term. Certain other terms shall have the meaning set forth elsewhere in this Lease and the Exhibits hereto. 
  
 “Base Rent” means the basic rent payable by Tenant per month during the Term in the amounts shown on the Lease Summary and in the manner
provided In Suction 4. 
  
 “Building” means the
building described in the Lease Summary and any future expansions of that building. 
  
 “business days” means Monday through Friday, except holidays; “holidays” means those holidays specified by the laws of the United States or State of California, and all
holidays to which maintenance employees of the Building are entitled from time to time under their union contract or other agreement, 
  
 “Commencement Date” means the earlier of (i) the date that Landlord delivers possession of the Premises to Tenant, or (ii) the date set
forth on the Lease Summary as the Estimated Commencement Date. 
  
 “Common Areas” means the Building’s common entrances, lobbies, restrooms, elevators, stairways and accessways, loading docks, ramps, drives, platforms and passageways and serviceways thereto, and the common pipes,
conduits, wires and appurtenant equipment serving the Premises, together with trash areas, parking areas, roadways, sidewalks, walkways, parkways, driveways and landscaped areas and similar areas and facilities appurtenant to the Building.

  
 “Development” means that real properly
(including, without limitation, the Building, the Common Areas and the Premises) situated in the City of South San Francisco, County of San Mateo, State of California, being more particularly described on Exhibit A-1 attached hereto as such real
property may be modified from time to time by Landlord. 
  
 “Fair Market Rent” means the rate being charged in the Building for comparable space, taking into consideration: location in the Building, tenant improvements or allowances provided or to be provided, rental abatements,
lease takeovers/ assumptions, moving expenses and other forms of 

 rental concessions, proposed term of lease, extent of service provided or to be provided, the ownership of the comparable
space, the time the particular rate under consideration became or is to become effective and any other relevant terms or conditions. 
  
 “Guarantor” means any guarantor of any of Tenant’s obligations under this Lease. 
  
 “Landlord Parties” means the employees, agents, contractors,
officers, directors, partners, licensees, invitees, and guests of Landlord, Landlord’s affiliates, Landlord’s managing agent and Mortgagee. 
  
 “Lease Years” means successive periods of twelve (12) full calendar months, beginning on the Commencement Date. If the Commencement Date
is not the fast day of a month, then the first Lease Year also includes the partial month in which the Commencement Date occurs. 
  
 “Mortgage” means any mortgage or deed of trust, blanket or otherwise, covering any part of the Development “Mortgagee” means
the holder of a Mortgage. 
  
 “Operating
Expenses” means all expenses and costs (but not specific costs that are separately billed to and paid by specific tenants) of every kind and nature diet Landlord shall pay or incur or become obligated to pay or incur (including, without
limitation, costs incurred by managers and agents that are reimbursed by Landlord) because of or in connection with the management, maintenance, preservation, ownership and operation of the Development and its supporting facilities directly
servicing the Development (as allocated to the Development in accordance with generally accepted accounting principles, consistently applied) including, but not limited to, the following: 
  
 (a) Wages, salaries and reimbursable expenses and benefits of all on-site and off-site personnel engaged in the operation,
maintenance and security of the Development and the direct costs of training such employees, limiting such charges only to amounts directly allocable to services tendered by the employers and personnel for the benefit of the Development 

 
 (b) Costs of the property management office and office operation.

  
 (c) All supplies, materials and rental equipment used in the
operation and maintenance of the Development, including, without limitation, temporary lobby displays and events, the cost of erecting, maintaining and dismantling art work and similar decorative displays commensurate with operation of a first class
office building. 
  
 (d) Utilities, including, without limitation,
water, power, gas, sewer, waste disposal, communication and cable T.V. facilities, heating, cooling, lighting and ventilation of the Development 
  
 (e) All maintenance, janitorial and service agreements for the Development and the equipment therein, including, but not limited to, alarm service, window
cleaning, elevator maintenance, and maintenance and repair of sidewalks, landscaping, Building exterior and service areas. 
  

 -2- 

 (f) A management cost recovery equal to three percent (3%) of all revenues (excluding such management
cost recovery) derived from the Development. 
  
 (g) Legal and
accounting services for the Development including, but not limited to, the costs of audits by certified public accountants of Operating Expenses records and reasonable legal fees and costs incurred by Landlord in any legal proceeding against any
other specific tenant where such other tenant is responsible (either pursuant to its lease or at law) for payment of such fees and costs but is unwilling or is unable to pay such fees and costs after reasonable efforts have been made by Landlord to
pursue reimbursement from such tenant; provided, however, that legal expense shall not include the cost of negotiating lease terms for prospective tenants, (ii) negotiating termination or extension of leases with existing tenants, (iii) proceedings
against any other specific tenant relating solely to the collection of rent or other sums due to Landlord from such tenant, or (iv) legal costs incurred in connection with development and/or construction of the Development 
  
 (h) All insurance premiums and costs, including, but not limited to, the
premiums and cost of fire, casualty, liability, rental abatement and earthquake insurance applicable to the Development and Landlord’s personal property used in connection therewith (and all amounts paid as a result of loss sustained that would
be covered by such policies but for commercially reasonable “deductible” or self-Insurance provisions); provided., however, that Landlord may, but shall not be obligated to, carry earthquake insurance (if Landlord elects to carry
earthquake insurance, Tenant shall not be responsible for premium costs for such earthquake insurance in excess of premiums customarily charged for earthquake insurance to landlords of similar buildings in the Northern San Mateo County area).

  
 (i) Repairs, replacements and general maintenance (except for
repairs and replacements (i) paid for from the proceeds of insurance, (ii) paid for directly by Tenant, other tenants or any thud party, or (iii) for the benefit solely of tenants of the Development other than Tenant to the extent that Tenant could
not obtain similar services from Landlord without an obligation to reimburse Landlord for the entire cost thereof under the provisions of this Lease). 
  
 (j) All real and personal property taxes and general and special assessments imposed by any governmental authority or agency on the Building and a pro
rata portion of any taxes and general and special assessments levied on the Development; any assessments levied in lieu of or in substitution for, such taxes; and any other costs, fees or charges levied or assessed by, or at the direction of, any
federal, state, or local government authority in connection with the ownership, use or occupancy of the Development, whether or not now in effect or foreseeable (excluding penalties, fines and interest charges imposed as a result of Landlord’s
failure to pay timely the same; provided that, Tenant has timely paid its proportionate share of Operating Expenses hereunder); and any reasonable expenses, including the reasonable cost of attorneys or experts, incurred by Landlord in seeking
reduction by the taxing authority of the above-referenced taxes, less any tax refunds obtained on account of such taxes previously paid and for which Tenant has paid Tenant’s Share thereof as a result of an application for review thereof;
provided, however, that such taxes shall not include (i) taxes paid by Tenant pursuant to Section 9 or by other tenants in the Development pursuant to similar provisions in their leases; or (h) franchise, transfer, inheritance, or capital stock

  

 -3- 

 taxes or income taxes measured by the net Income of Landlord from all sources, unless, due to a change in the method of
taxation, any of such taxes is levied or assessed against Landlord as a substitute for, or as an addition to, to whole of in part, any other tax that would otherwise constitute the taxes described in the preceding provisions of this clause (j).

  
 (k) Amortization (together with reasonable financing charges)
of capital improvements made to the Development that (i) are or will be required to comply with applicable law, ordinance, rule or regulation, enacted or enforced after the Commencement Date; (ii) are replacements of items which Landlord is
obligated to maintain; or (iii) are intended to improve the operating efficiency of the Development; provided, however, that in the case of improvements trade solely for efficiency purposes, the amount chargeable as an Operating Expense in any year
shall not exceed Landlord’s reasonable determination of the efficiency achieved either in direct cost savings, avoidance of cost increases or a combination of both. As used in this definition of Operating Expenses, “amortization”
shall mean allocation of the cost equally to each year of useful life of the items being amortized or a shorter period equal to the number of years required to recover the cost of said item of capital improvement out of the savings in operating
efficiency derived therefrom. Notwithstanding the foregoing, however, Landlord may treat as expenses (chargeable in the year earned) and not as capital casts items that are less than two percent (2%) of estimated Operating Expenses for the year in
question. 
  
 Notwithstanding any other provision herein to the
contrary, if the Development is not fully occupied during any year of the Term, an adjustment shall be made in computing Operating Expenses for such year so that Operating Expenses shall be computed as though the Development had been fully occupied
during such year, provided, however, that in no event shall Landlord collect in total, from Tenant and all other tenants of the Development, an amount greater than one hundred percent (100%) of the actual Operating Expenses during any year of the
Term. 
  
 “Operating Expense Base” means the
dollar amount per square foot of the Rentable Area as set forth on the Lease Summary. ‘ 
  
 “Prime Rate” means the rate of interest from time to time announced by Bank of America National Trust and Savings Association as its reference rate or, if no such rate is being announced, such
reasonable substitute as Landlord may select. 
  
 “Premises” means the floor area more particularly shown on the floor plan attached hereto as Exhibit A, containing the approximate area of rentable square feet described on the Lease Summary. Landlord hereby reserves, for
its sole and exclusive use, any and all mechanical, electrical, telephone and similar rooms, janitor closets, elevator, pipe and other vertical shafts and ducts, flues and stairwells; the area above the acoustical ceiling; facilities serving parts
of the Development other than the Premises; and any other area not shown on Exhibit A as being part of the Premises. 
  
 “Related Parties” of a party means its employees, agents, contractors, officers, directors, partners, licensees, Invitees and guests.

  

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 “Rent” means the Base Rent, Additional Rent, and any and all other charges of any nature
payable by Tenant to Landlord under this Lease. 
  
 “Rentable Area” means the number of square feet of the Premises and the Building, as applicable, set forth on the Lease Summary. 
  
 “Rules and Regulations” means the rules and regulations (as changed from time to time as therein provided) attached hereto as Exhibit F.

  
 “Tenant Parties” means the employees, agents,
contractors, officers, directors, partners, licensees, invitees and guests of Tenant 
  
 “Tenant’s Share” means Rentable Area of the Premises divided by the greater of (a) ninety-five percent (95%) of the Rentable Area of the Building, or (b) the Rentable Area of the Building that is
actually occupied by tenants, as such area changes from time to time. The agreed-upon areas stated in this Lease (or in the Lease Commencement Certificate, if different) shall be used to determine Tenant’s Share unless either of said areas
materially changes. 
  
 “Term” means the period
commencing on the Commencement Date and ending on the Termination Date. 
  
 “Termination Date” means the date which is the number of Lease Years and months set forth on the Lease Summary alter the Commencement Date or such earlier date upon which this Lease is terminated pursuant to the provisions
herein. Upon determination of the Commencement Date, Landlord and Tenant will execute a certificate in the form of Exhibit B specifying the Commencement Date and the Termination Date as determined with reference to the Lease Summary. 
  
 “Year or year” means a calendar year. 
  
 2. DEMISE 
  
 For the Term, Landlord leases the Premises to Tenant and Tenant leases the same from Landlord, all upon and subject to the
terms and conditions of this Lease. Tenant hereby acknowledges that Landlord may deliver to Tenant either the Suite 950 Space or the Suite 990 Space prior to the Estimated Commencement Date, whereupon the Lease shall commence with respect to the
space so delivered upon all the berths, covenants and conditions contained in this Lease, including, without limitation, the obligation to pay Rent for the space so delivered. Tenant hereby acknowledges that if Landlord, for any reason whatsoever,
cannot deliver possession of the Premises to Tenant on the Commencement Date or upon the full execution of this Lease, whichever is later, this Lease shall not be void or voidable by Tenant, nor shall Landlord be liable to Tenant for any loss or
damage resulting therefrom; provided, however, if Landlord fails to deliver to Tenant possession of both the Suite 950 Space and the approximately two thousand one hundred thirty-eight (2,138) square feet of rentable area (being a portion of Suite
900 of the Building) being concurrently subleased to Tenant (the “Sublease Premises”) on or before August 1, 1999, then Tenant may, at its option and as its sole and exclusive remedy for such failure, terminate this Lease by delivering

  

 -5- 

 written notice of such termination to Landlord by August 10, 1999 but before Landlord delivers to Tenant possession of
both the Suite 950 Space and the Sublease Premises. If Tenant so terminates this Lease, then Landlord shall immediately return to Tenant all amounts previously paid by Tenant to Landlord under this Lease (and under the sublease of the Sublease
Premises, if applicable excluding any amounts that Tenant may owe to Landlord pursuant to the terns of this Lease and excluding any portion of the Security Deposit used by Landlord to curs any defaults on the part of Tenant or otherwise used by
Landlord in accordance with the provisions of Section 6 of this Lease, and thereafter neither party shall have any further obligations under this Lease, other than those obligations that expressly survive the termination or earlier expiration of
this Lease. If Tenant fails to so terminate this Lease, this Tease shall not terminate but shall remain in full force and effect upon the same terms and conditions set forth in this Lease. 
  
 If Landlord fails to deliver to Tenant possession o& the Suite 980 Space
on or before August 1, 1999, then, Tenant may, at is option and as its sole and exclusive remedy for such failure, terminate this Lease for the Suite 980 Space by delivering written notice of such termination to Landlord by August 10, 1999 but
before Landlord delivers to Tenant possession of the Suite 980 Space. If Tenant so terminates this Lease for the Suite 980 Space, then Landlord shall immediately return to Tenant all amounts previously paid by Tenant to Landlord under this Lease for
the Suite 980 Space, excluding any amounts that Tenant may owe to Landlord pursuant to the terms of this Lease for the Suite 980 Space and excluding any portion of the Security Deposit for the Suite 980 Space used by Landlord to cure any defaults on
the part of Tenant or otherwise used by Landlord in accordance with the provisions of Section 6 of this Lease, and thereafter neither party shall have any further obligations under this Lease for the Suite 980 Space, other than those obligations
that expressly survive the termination or earlier expiration of this Lease, and if Tenant has not terminated the Lease in accordance with the provisions of the immediately foregoing paragraph of this Section 2, this Lease with regard to the Suite
950 Space shall remain in full force and effect upon the terms, covenants and conditions specified in this Lease and thereafter the “Premises” shall mean the Suite 950 Space and all calculations based upon the square footage of the
Premises shall be adjusted to include only the Suite 950 Space. If Tenant fails to terminate this Lease for the Suite 980 Space in accordance with the provisions of this Section 2 and if Tenant has not terminated this Lease in accordance with the
provisions of the Immediately foregoing paragraph of this Section 2, then the Lease for the Suite 980 Space (and for the Suite 950 Space) shall not terminate but shall remain in full force and effect upon the same terms and conditions set forth in
this Lease. 
  
 So long as it is entitled to possess the Premises,
Tenant may (with others) use the Common Areas on a nonexclusive basis for their intended purposes; provided, however, Landlord shall have the sole and exclusive right to possession and control of the Common Areas. So long as reasonable access and
services (including Tenant’s parking spaces described in the Lease Summary) to the Premises are available, Landlord may (a) install, use, maintain, repair, relocate and replace pipes, ducts, conduits, wires and appurtenant meters and equipment;
(b) change the Common Areas, including, without limitation, the location, size, shape and number of driveways, entrances, parking spaces, parking areas, loading and unloading areas, ingress, egress, direction of traffic, landscaped areas and
walkways; (c) close temporarily, or eliminate permanently, any Common Areas; (d) designate other land as Common Areas; (e) add additional buildings and improvements to the 
  

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 Common Areas, and lease such buildings and improvements and/or existing buildings and improvements on the Common Areas;
(f) use the Common Areas in making expansions, additional improvements, repairs or alterations to any part of the Development; and (g) do and perform such other acts and make such other changes in, to or with respect to the Development as Landlord
may, in the exercise of sound business judgment, deem to be appropriate. 
  
 3.
ACCEPTANCE OF PREMISES 
  
 Tenant hereby acknowledges that the Premises is leased to Tenant in its present “as-is” condition, and Landlord shall have no obligation to install any alterations, additions or improvements or do any work whatsoever to the
Premises. Tenant further acknowledges that it is currently in possession of the Suite 950 Space pursuant to an assignment of that certain Gateway Office Building Lease dated September 15, 1989, by and between Homart Development Co., a Delaware
corporation, Landlord’s predecessor in interest, and Shakey’s Incorporated, a Delaware corporation (“Shakey’s”), as amended (collectively, the “Shakey’s Lease”). Concurrently with the execution of this Lease,
Landlord, Tenant and Shakey’s are executing an agreement terminating the Shakey’s Lease and the assignment thereof by Shakey’s to Tenant (the “Shakey’s Lease Termination Agreement”). Notwithstanding anything to the
contrary contained in this Lease, Tenant and Landlord hereby acknowledge that this Lease is expressly conditioned upon Tenant and Shakey’s executing and delivering to Landlord the Shakey’s Lease Termination Agreement in a form reasonably
acceptable to Landlord. If for any reason the Shakey’s Lease is not terminated pursuant to the Shakey’s Lease Termination Agreement, this Lease shall terminate and thereafter neither party shall have any further obligation under this
Lease, except for those obligations which by their terms survive the termination of this Lease. 
  
 The current tenant of the Suite 980 Space (the “Suite 980 Tenant”) is executing a lease termination agreement (the “Suite 980 Lease
Termination Agreement in which Suite 980 Lease Termination Agreement shall terminate the current lease for the Suite 980 Space (the “Suite 980 Lease”). Tenant and Landlord hereby acknowledge that this Lease as it relates to the Suite 980
Space only is expressly conditioned upon the Suite 980 Tenant’s executing and delivering to Landlord the Suite 980 Lease Termination Agreement in a form reasonably acceptable to Landlord. If for any reason the Suite 980 Lease is not terminated
pursuant to the Suite 980 Lease Termination Agreement, this Lease with respect to the Suite 980 Space only shall terminate and thereafter neither party shall have any further obligation under this Lease for the Suite 980 Space, except for those
obligations which by their terms survive the termination of this Lease, and this Lease with regard to the Suite 950 Space shall retrain in full force and effect upon the terms, covenants and conditions specified in this Lease and thereafter the
“Premises” shall mean the Suite 950 Space and all calculations based upon the square footage of the Premises shall be adjusted to include only the Suite 950 Space. 
  

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 4. RENT 
  
 From the Commencement Date, Tenant will pay Landlord, at the address specified in the Lease Summary or at such other address as may be designated by
Landlord from time to time and without prior notice, demand, offset or deduction (except as otherwise expressly set forth herein), the following rent. 
  
 4.1 Base Rent 
  
 Tenant shall pay the Base Rent to advance on the fast day of each month during the Term hereof; except that the first full month’s Base Rent shall be
paid upon execution of this Lease. If the Term commences on other than the fast day of a month, the Base Rent provided for such partial month shall be prorated and the prorated installment shall be paid on the first day of the calendar month
succeeding the Commencement Date. If the Term terminates on outer than the first day of a calendar month, the Base Rent provided for such partial month shall be prorated and such prorated installment shall be paid on the first day of the calendar
month preceding the Termination Date. 
  
 4.2 Additional
Rent 
  
 Tenant shall pay as additional rent
(“Additional Rent’s Tenant’s Share of Operating Expenses in excess of the Operating Expense Base multiplied by the Rentable Area. For partial years, the Operating Expenses will be calculated on a full-year basis, and then prorated.
Tenant shall pay monthly installments of Additional Rent on the first day of each month, in amounts specified in good faith by Landlord from time to time, which, by the end of each year (or by the Termination Date, if earlier), will total
Landlord’s estimate of Additional Rent paid for such year. By the following April 1, or as soon thereafter as practicable, Landlord will furnish Tenant a statement of Operating Expenses and Additional Rent for such year. Any amounts owing for
that year shall, within thirty (30) days thereafter, be paid by Tenant to Landlord. Any amounts overpaid shall, at Landlord’s option, be credited against the next installment(s) of Additional Rent due from Tenant, or be refunded to Tenant. This
obligation survives termination or the earlier expiration of this Lease. 
  
 5.
SECURITY DEPOSIT 
  
 Concurrently with execution hereof, Tenant shall pay to Landlord the Security Deposit set forth on the Lease Summary as security for the full and faithful performance of Tenant’s obligations under this Lease, which amount shall be paid
as follows: Landlord shall credit to the Security Deposit the amount of Twelve Thousand Two Hundred Thirty-Six and 40/100ths Dollars ($12,236.40), which Tenant paid to Landlord as a security deposit pursuant to the Shakey’s Lease; and Tenant
shall pay to Landlord the amount of Fifteen Thousand Nine Hundred Eighty-One and 45/100ths Dollars ($15,981.45). Landlord may (but shall not be required to) use the Security Depositor any portion thereof to cure any defaults on the part of Tenant or
to compensate Landlord for any damage Landlord incurs as a result of Tenant’s failure to perform any of its covenants or obligations hereunder, it being understood that any use of the Security Deposit shall not constitute a bar or defense to
any of Landlord’s remedies under this Lease, at law or in equity. In such event, and upon written notice from Landlord to Tenant specifying the amount of the Security Deposit so 
  

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 utilized by Landlord and the particular purpose for which such amount was applied, Tenant shall Immediately deposit with
Landlord an amount sufficient to return the Security Deposit to the amount specified in the Basic Increase Information. Upon termination or earlier expiration of this Lease, the Security Deposit shall lie returned to Tenant, reduced by those amounts
that may be required by Landlord to remedy defaults on the part of Tenant in the payment of Rent, to repair damage to the Premises caused by Tenant or Tenant Parties and to clean the Premises to a broom-clean condition. The portion of the Security
Deposit not so required shall be paid over to Tenant promptly after expiration of the Term. Landlord shall hold the Security Deposit for the foregoing purposes; provided, however, that Landlord shall have no obligation to segregate the Security
Deposit from its general funds or to pay interest thereon. If Landlord conveys or transfers its interest in the Building and as a part of such conveyance or transfer, assigns its interest in this Lease and Security Deposit and the transferee assumes
the same in writing, or any portion thereof not previously applied, the Security Deposit shall be transferred to Landlord’s successor and Landlord shall be released and discharged from any further liability to Tenant with respect to such
Security Deposit. In no event shall any Mortgagee under a Mortgages or any purchaser of all or any portion of the Development at a public or private foreclosure sale under a mortgages have any liability or obligation whatsoever to Tenant or
Tenant’s successors or assigns for the return of all or any part of the Security Deposit in the event any such Mortgagee or purchaser becomes a mortgagee in possession or succeeds to the interest of Landlord under this Lease unless, and then
only to the extent that, such Mortgagee or purchaser has received all or any part of the Security Deposit: 
  
 6. SERVICES PROVIDED BY LANDLORD 
  
 Landlord agrees to furnish or cause to be furnished to the Premises the utilities and services as described in Exhibit C, subject to the standards set
forth therein. Tenant shall obtain all utilities and services from vendors designated by Landlord, which vendors shall be selected in Landlord’s sole and absolute discretion, and Tenant shall have no right to obtain any utilities or services
from any vendors other than those so designated by Landlord; provided, however, in no event shall Tenant be responsible for any charges from such venders in excess of the costs charged by similar, reputable venders of such services to buildings in
the Northern San Mateo County area comparable to the Building and otherwise consistent with an arm’s-length agreement In the event any rule or regulation of applicable utilities or governmental authority restricts the services to be provided
hereunder, Landlord shall not be in default hereof and Tenant shall not be entitled to an abatement of Rent Landlord does not warrant that the services provided for in this Section 6 will be free from any irregularity or stoppage. Landlord shall use
commercially reasonable efforts to correct the same, but no such condition or event will create any liability for Landlord or Landlord Parties, or constitute an eviction, actual or constructive, of Tenant, or cause any abatement of the rent payable
under this Lease or relieve Tenant of any of its obligations under this Lease. Notwithstanding any other provision in this Paragraph 6 to the contrary, if such utilities or services shall, by reason of Landlord’s negligence or willful
misconduct and through no fault of Tenant, be interrupted or suspended and not restored within three (3) business days after written notice from Tenant to Landlord, and if by reason of such interruption or suspension Tenant is unable to conduct its
business operations from the Premises, then Landlord shall refund to Tenant an amount equal to the Base Rent (prorated on a daily basis) paid by Tenant for the period from the date of such interruption 
  

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 or suspension until such service is restored or reasonably satisfactory alternative service is provided in its place.

  
 7. USE; HAZARDOUS SUBSTANCES

  
 7.1 Use of Premises 
  
 Tenant will use and occupy the Premises only for the purpose set forth in the
Lease Summary and no other purpose whatsoever, using and maintaining them in a clean, careful, safe, sanitary and proper manner. Tenant will pay for any damage to any part of the Development caused by any negligence, willful act, misuse or abuse by
Tenant or Tenant Parties. Tenant and Tenant Parties will comply with the Building’s Rules and Regulations and will not cause anywhere in the Development, or permit in the Premises, (a) any activity or thing (i) contrary to applicable law,
ordinance, regulation, restrictive covenant, or insurance regulation, including, without limitation, the Americans with Disabilities Act, 42 U.S.C. § 12101 et seq. and any governmental regulations relating thereto, including any required
alterations for purposes of “public accommodations” under such statute; or (ii) which jeopardizes the coverage of normal insurance policies or increase their cost; (b) defacing or injury to the Development; (c) waste or nuisance, or any
activity causing noise or odors perceptible outside the Premises; (d) cooking or heating food, except for incidental use, solely for Tenant Parties, of microwave ovens and beverage-brewing devices, provided that the foregoing do not use a flame and
are approved by Underwriters Laboratories for residential use; (e) sale, purchase or gift of any merchandise or storage therefor, including, without limitation, any use of vending machines (except for the use of those vending machines approved by
Landlord in writing, which approval shall not be unreasonably withheld); or (f) overloading of the floors or any of the structural or mechanical systems of the Building. Tenant shall not erect or place any item in or upon the Common Areas. Tenant
will conduct its business and occupy the Premises and shall not unreasonably interfere with, annoy or disturb any other tenants in the Development or the Landlord in its management thereof Tenant shall not erect or place any item (including, without
limitation, signs) in, upon or visible from the exterior of the Building or the Common Areas of the Development; provided, however, Tenant shall be entitled to maintain its existing sign on the temporary monument sign of the Development at its sole
cost and expense until such time that Landlord removes the monument sign from the Development. In its sole and absolute discretion, and thereafter, Tenant shall have no further right to erect or place any sign in, upon or visible from the exterior
of the Building or the Common Areas of the Development. 
  
 7.2 Hazardous Substances 
  
 Tenant shall
not generate, use, manufacture, keep, store, refine, release, discharge or dispose of any substance or material that is described as a toxic or hazardous substance, waste or material or a pollutant or contaminant by any federal, state or local law,
ordinance, rule or regulation now or hereafter in force, as amended from time to time, in any way relating to or regulating human health or safety or industrial hygiene or environmental conditions or pollution or contamination, including, without
limitation, the Comprehensive Environmental Response, Compensation and Liability Act of 1980, 42 U.S.C. § 9601, et seq., the Solid Waste Disposal Act, 42 U.S.C. § 6901, et seq., the Hazardous Substance Account Act, California Health and
Safety Code § 25300, et seq., the 
  

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 Hazardous Waste Control Law, California Health and Safety Code § 25100, et seq., and the Porter-Cologne Water
Quality Control Ad, California Water Code § 13000, et seq., including, without limitation, PCBs, petroleum products, asbestos and asbestos-containing materials (collectively, “Hazardous Substances”), on, under or near the Development,
except that Tenant may use Hazardous Substances on the Premises that are incidental to and only in quantities reasonably required for general office use, such as photocopier toner and household cleaner, provided such use is in full compliance with
all applicable laws and prudent business practices. Except as specifically provided above, Tenant shall ensure that Tenant and Tenant’s Parties shall not cause or permit any waste material or refuse to be dumped upon or remain upon any part of
the Development, and Tenant shall ensure that Tenant and Tenant’s Parties shall not cause or allow any materials, supplies, equipment, finished products or semi-finished products or articles of any nature to be stored upon or remain upon the
Development. Tenant shall indemnify, defend and hold Landlord and Landlord Parties harmless from any and all Liabilities (as defined in Section l4), incurred in connection with or arising from the generation, use, manufacture, keeping, storage,
refinement, release, discharge or disposal of any Hazardous Substances by Tenant, any Tenant Parties or any person claiming through or under Tenant or any Tenant Party on or about the Development. The foregoing indemnity shall survive termination or
earlier expiration of this Lease. 
  
 8. BROKERS 

 
 Tenant warrants that it has had no dealing with any broker or agent other
than the Broker specified in the Lease Summary in connection with this Lease. Tenant hereby acknowledges that it is solely responsible for the payment of any commissions or other compensation or charges claimed by Broker (“Broker Fees”);
provided, however, Landlord hereby acknowledges that Tenant shall be entitled to use a portion of the Allowance (as defined in Section 10.2, below) for the payment of any Broker Fees owing in connection with this Lease. Tenant shall indemnify,
defend and hold Landlord and Landlord Parties harmless from and against any and all Liabilities for commissions or other compensation or charges claimed by any other broker or agent based on dealings with Tenant with respect to this Lease. Landlord
warrants that it has had no dealings with any broker or agent in connection with this Lease. Landlord shall indemnify, defend and hold Tenant and Tenant Parties harmless from and against any and all Liabilities for commissions or other compensation
or charges claimed by any broker or agent based on dealings with Landlord with respect to this Lease. The foregoing indemnities shall survive termination or earlier expiration of this Lease. 
  
 9. TENANT’S TAXES 
  
 (a) In addition to Tenant’s obligations under Section 4.2, Tenant shall
be responsible for and shall pay, at least ten (10) days before delinquency, all taxes, fees or charges levied or assessed against or attributable to any personal property or trade fixtures in the Premises or by reason of leasehold improvements. If
any such taxes, fees or charges are included in Landlord’s taxes, Landlord may pay them regardless of the validity (under proper protest if requested by Tenant and at Tenant’s sole cost and expense), and Tenant will pay Landlord the amount
of Landlord’s taxes attributable to Tenant, as determined In good faith by Landlord, within thirty (30) days after 
  

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 Landlord delivers to Tenant written demand supported by reasonably satisfactory evidence of the taxes attributable to
Tenant. 
  
 (b) In addition to all other sums to be paid by Tenant
tinder tills Lease, Tenant shall pay, before delinquency, any and all taxes levied or assessed during the Term, whether or not now customary or within the contemplation of the parties hereto, (i) upon or measured by Base Rent or Additional Rent, or
both, payable under tills Lease, including, without limitation, any gross income tax or excise tax levied by the city and/or county in which the Building is located, the State of California, the Federal Government or any other governmental body with
respect to the receipt of such rental; (ii) upon or with respect to the possession, leasing; operation, management, maintenance, alteration,, repair, use or occupancy by Tenant of the Premises or any portion thereof; or (iii) upon this transaction
or any document to which Tenant Is a party creating or transferring an interest or an estate in the Premises. 
  
 10. ALTERNATIONS, REPAIRS AND MAINTENANCE 
  
 10.1 Repairs and Maintenance 
  
 (a) Subject to Sections 4.2, 10.1(b), 17 and 18, Landlord shall repair and maintain (i) the structural portions of the Building, (ii) the exterior walls
of the Building, including glass and glazing, (iii) the roof, (iv) those portions of the mechanical, electrical, plumbing, HVAC and life safety systems serving the Building (the “Systems”) (excluding any connections or elements thereof
installed by Tenant) and (v) the Common Areas. Any repair caused in part of in whole by the act, neglect or omission of Tenant or any Tenant Parties shall be trade by Landlord at the sole cast and expense of Tenant. 
  
 (b) Throughout the Term, Tenant shall at its sole cost and expense (i) keep,
maintain and repair the Premises in first class condition and repair, ordinary wear and tear and damage from any casualty or condemnation for which Tenant is not responsible or liable under the Lease excepted, (ii) make all nonstructural repairs and
replacements to the Premises, and (iii) keep, maintain and repair all Systems installed by Tenant, fixtures and supplemental HVAC units in good working order, unless Landlord elects, at Tenant’s sole cost and expense, to perform such work. In
performing the obligations under this Section 10.1(b), Tenant shall notify Landlord of any repairs that could affect the Systems serving the Building (exclusive of the Premises) and shall use contractors approved by Landlord, in its reasonable
discretion. Landlord shall have the right but not the obligation to undertake work that Tenant is required to perform under this Lease and that Tenant fails or refuses to perform in a timely and efficient manner. All reasonable costs incurred by
Landlord in performing any such maintenance or repair for the account of Tenant, together with an administrative fee equal to ten percent (10%) of such costs, shall be repaid by Tenant to Landlord within thirty (30) days after Landlord delivers to
Tenant written demand supported by invoices or other reasonably satisfactory evidence of such costs. 
  
 (c) Subject to Section 6 and Section 17.3, there shall be no abatement of rent and no liability of Landlord by reason of any injury to or interference
with Tenant’s business arising from the making of any repairs, alterations or improvements in or to any portion of the 
  

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 Development, or in or to fixtures, appurtenances and equipment therein. Tenant waives the right to make repairs at
Landlord’s expense under any law, statute or ordinance now or hereafter in effect. 
  
 10.2 Alterations 
  
 Tenant will not make or permit alterations, improvements or additions (including fixtures) in or to the Premises (collectively “Alterations”) without Landlord’s prior written consent; which consent shall not be unreasonably
withheld. Tenant’s request for such consent shall be in writing, accompanied by proposed detailed plans and specifications. Landlord may require Tenant to provide Landlord, at Tenant’s sole cost and expense, a lien and completion bond in
an amount equal to one and one-half times the estimated cost of such Alterations, to insure Landlord against any liability for any mechanic’s and materialmen’s liens and to insure completion of the work Alterations will be performed, if
Landlord elects, by Landlord or a contractor designated by Landlord, at Tenant’s sole cost and expense. Tenant may engage its own contractors to perform remodel work upon written approval by Landlord In such event, Landlord shall charge a
fifteen percent (15%) administrative fee on all construction costs. Any and all plans must be submitted to Landlord for approval, and building permits must be obtained by Tenant prior to commencement of any construction remodeling. Subject to
Section 24.1, all Alterations will become Landlord’s property and a pact of the Building without compensation to Tenant. Tenant will promptly notify Landlord of the value thereof for insurance purposes. Tenant shall indemnify, defend and hold
Landlord and Landlord Parties harmless from and against any and all Liabilities incurred in connection with or arising from any work performed by or on behalf of Tenant. 
  
 If Landlord gives its consent to Tenant’s making such Alterations, the consent shall be deemed conditioned upon
Tenant’s acquiring all permit and approvals required to lawfully do so from applicable governmental agencies, furnishing a copy thereof to Landlord prior to the commencement of the work, and compliance by Tenant with all conditions of said
permits and approvals in a prompt and expeditious manner. Unless Landlord so specifies when it gives such consent, Tenant shall not be obligated to remove any Alterations upon the expiration or earlier termination of the Term. Tenant shall give
Landlord not less than ten (10) days notice prior to the commencement of any work in the Premises by Tenant, and Landlord shall have the right to post notices of nonresponsibility in or on the Premises or other parts of the Development as provided
by law. All Alterations, repairs and replacements by Tenant shall be in accordance with all applicable laws, rules and ordinances and the requirements of any insurance carrier, and shall be of a quality and class at least equal to the original work,
performed in a good and workmanlike manner with good grades of materials approved by Landlord. Tenant will give Landlord opportunity to inspect and monitor all work Tenant shall provide Landlord with as-built plans and specifications for Alterations
promptly upon their completion. Should Tenant make any Alterations without Landlord’s prior written approval, or in violation of such approval or the requirements of this Section 10.2, Landlord may, at any time during the Term, either remove
any part or all of the same on Tenant’s behalf or require that Tenant do so all at Tenant’s sole cost and expense. All reasonable costs incurred by Landlord in removing any such alterations shall be repaid by Tenant to Landlord immediately
upon demand, together with an administrative fee equal to fifteen percent (15%) of such costs. 
  

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 Subject to the terms of this Section 10.2, Landlord hereby consents to Tenant (i) upon delivery to Tenant
of both the Suite 950 Space and the Sublease Premises, removing the current demising wall that separates the Suite 950 Space from the Sublease Premises (the “Sublease Demising Wall”), (ii) upon delivery by Landlord to Tenant of both the
Suite 950 Space and the Suite 980 Space, removing the current demising wall that separates the Suite 950 Space from the Suite 980 Space (the “Suite 980 Demising Wall, and (iii) making minor Alterations that may be required in connection with
the removal of each of the Sublease Demising Wall and the Suite 980 Demising Wall (collectively, the “Demising Alterations”); provided, however, and notwithstanding anything to the contrary contained herein, upon the expiration or earlier
termination of the Term Tenant, at Landlord’s request, shall remove any Demising Alterations and repair any damage to the Suite 950 Space, the Sublease Premises and/or the Suite 980 Space as a result of the Demising Alterations and Tenant shall
reconstruct the Sublease Demising Wail and the Suite 980 Demising Wall each to the same condition in which each, existed at the commencement of the Term. Landlord hereby agrees to reimburse Tenant for the out-of-pocket costs Tenant actually incurs
for the Demising Alterations and for any Broker Fees as set forth in Section 8, but in no event shall Landlord’s reimbursement obligation pursuant hereto, in the aggregate, exceed Thirty Thousand Dollars ($30,000.00) (the
“Allowance”). All costs in excess of the Allowance shall be the sole responsibility of Tenant Landlord shall make such reimbursement to Tenant within thirty (30) days after Tenant delivers to Landlord written demand supported by invoices,
receipts and other documents reasonably acceptable to Landlord as evidence of the lien-free completion of said improvements in accordance with the provisions of this Lease and all applicable laws and as evidence of the payment of Broker Fees by
Tenant; as applicable. Any and all costs not properly submitted to Landlord by May 31, 2000 shall not be reimbursable hereunder and shall be at Tenant’s sole cost and expense. Any excess allowance not properly claimed by Tenant pursuant hereto
shall, after May 31, 2000, be forfeited by Tenant and remain the exclusive property of the Landlord. 
  
 11. LIENS 
  
 Tenant shall not permit any lien to exist on or against any part of the Development allegedly resulting from any work or materials furnished or obligations incurred by or for Tenant. Tenant shall discharge arty such lien of record or post a
bond in accordance with applicable law as soon as reasonably possible after such lien is filed; provided, however, if no liens are allowed pursuant to Landlord’s Mortgage now or hereafter existing on any part of the Building or the Development,
Tenant shall discharge any such lien of record immediately upon its filing. Neither this Lease, nor any request or consent of Landlord to the labor, materials or obligations, shall be a consent to any such lien. Landlord may keep posted on the
Premises any notices it deems necessary for protection from such liens. If Tenant fails to discharge any such lien, or to post a bond, or to contest such lien by appropriate legal proceeding, or if any such lien jeopardizes Landlord’s interest
in the Development or is otherwise prohibited by Landlord’s Mortgage now or hereafter existing on any part of the Building or the Development, then Landlord may cause such lien to be released by any means it deems proper, including payment, at
Tenant’s sole cost and expense and without affecting Landlord’s rights. All reasonable costs incurred by Landlord in causing such liens to be released, together with an administrative fee equal to ten percent (10%) of such costs, shall be
repaid by 
  

 -14- 

 Tenant to Landlord within thirty (30) days after Landlord delivers to Tenant written demand supported by invoices or
other reasonably satisfactory evidence of such costs. 
  
 12.
ENTRY 
  
 Landlord may enter any part of the
Premises at all reasonable hours following reasonable prior notice to Tenant (or in any emergency or suspected emergency, at any hour, without notice), to (a) inspect, test, clean, or make repairs, alterations and additions to the Building or the
Premises as Landlord believes appropriate, or (b) provide any service which Landlord is now or hereafter obligated to furnish to tenants of the Building, or (c) show the Premises to prospective lenders, purchasers or tenants (but, with respect to
tenants, only during the last six (6) months of the Term) and, if they are vacated, to prepare them for reoccupancy. Rent will not abate because of Landlord’s entry. Landlord shall at all times have keys to all doors to or in the Premises.

  
 13. LANDLORD’S LIABILITY

  
 Tenant will protect its property and the person and
property of all Tenant Parties, and insure the same to its own satisfaction (including at least the insurance required hereunder), and accordingly waives any claim against Landlord and the Landlord Parties for loss or damage to any property, injury
to any person, or injury to Tenant’s business from any cause except for any damages directly caused (and specifically excluding any consequential damages) by Landlord’s willful misconduct or reckless ads. Tenant, for itself and all Tenant
Parties, assumes all risk of damage to person and property, proximate or remote. All personal property on the Premises is at Tenant’s risk only; the Landlord shall not be liable for any damage to or theft of such property. 
  
 14. INDEMNIFICATION AND EXCULPATION

  
 Tenant shall indemnify, defend and hold Landlord and the
Landlord Parties (collectively, “Indemnitee”) harmless from and against any and all fines, suits, losses, costs, expenses, liabilities, claims, demands, actions, damages and judgments (collectively, “Liabilities”) suffered by,
recovered from or asserted against the Indemnitee, of every kind and character, resulting from any breach, violation or nonperformance by Tenant of any provision of this Lease, and from injury or damage to person or property incident to, arising out
of or caused (proximately or remotely, in whole or in pan) by any act, omission, negligence or misconduct by Tenant or the Tenant Parties, or in any other way from Tenant or any Tenant Patties’ occupancy or use of or presence on the
Development. If any such proceeding is brought against an Indemnitee, Tenant will retain counsel reasonably satisfactory to Landlord to defend the Indemnitee at Tenant’s sole cost and expense. All such costs and expenses, including, without
limitation, attorneys’ fees and court costs, shall be payable by Tenant to Landlord immediately upon demand. Tenant’s obligations under this Section 14 shall survive the termination or earlier expiration of this Lease. 
  
 Landlord will indemnify, defend and hold Tenant harmless from all Liabilities
asserted against Tenant, to the extent that such Liabilities are proven by Tenant to have been caused by Landlord’s soulful misconduct or reckless acts. Landlord’s obligations under this Section 14 shall 
  

 -15- 

 include reimbursement to Tenant for reasonable attorneys’ fees and court costs incurred by Tenant in connection with
those Liabilities covered by Landlord’s indemnification as set forth herein. All costs and expenses, including attorneys’ fees and court costs, payable by Landlord to Tenant under this Section 14 shall be payable to Tenant within thirty
(30) days after Tenant delivers to Landlord written demand supported by invoices or other reasonably satisfactory evidence of such expenses. Landlord’s obligations under this Section 14 shall survive the termination or earlier expiration of
this Lease. 
  
 15. INSURANCE 
  
 Tenant, during the Term and any other period of occupancy, will at its sole
cost and expense maintain insurance reasonably satisfactory to Landlord, but in any event complying with the following minimum requirements: 
  
 (a) General Liability insurance with combined single limits not less than $2,000,000.00, for personal injury or death and property damage occurring in or
about or related to the use or occupancy of the Development by Tenant and any Tenant Parties. 
  
 (b) “All Risk” insurance for the full replacement cost of all Alterations, all Tenant’s property on the Premises and all fixtures. Unless this Lease is terminated upon damage or destruction, the
proceeds of such insurance will be used to restore the foregoing. 
  
 (c) Worker’s Compensation (as required by state law), and Employer’s Liability insurance in the amount of not less than $500,000.00. 
  
 (d) Loss of income and extra expense insurance in such amounts as will reimburse Tenant for direct or indirect loss of earnings or extra expenses
attributable to all perils commonly insured against by prudent tenants or attributable to prevention of access to the Development as a result of such perils. 
  
 All policies required hereunder will be issued by carriers rated A-VII or better by Best’s Kay Rating Guide and licensed to do business in the State
of California. The policies shall name Landlord and any other person or entity that Landlord may designate from time to time as additional insureds, with primary coverage noncontributing to any insurance landlord may carry, and shall provide that
coverage cannot be cancelled or materially changed except upon thirty (30) days’ prior written notice to Landlord and any additional insureds. At least thirty (30) days prior to expiration of such policies, and promptly upon any other request
by Landlord. Tenant shall furnish Landlord and any additional insureds with copies of policies, or certificates of insurance, evidencing maintenance and renewal of the required coverage. In the event Tenant does not maintain said insurance, Landlord
may, in its sole discretion and without waiving any other remedies hereunder, procure said insurance and Tenant shall pay to Landlord within thirty (30) days after written demand the cost of said insurance together with an administrative fee equal
to ten percent (10 %) of such costs. 
  

 -16- 

 During the Term, Landlord shall insure the Building (excluding any property which Tenant is obligated to
insure) against damage with All-Risk insurance and public liability insurance, all in such amounts and with such deductibles as Landlord in good faith considers appropriate; provided, however, such All-Risk insurance shall be in an amount equal to
at least the full replacement cost of the Building. Landlord may, but shall not be obligated to, obtain and carry any other form or forms of insurance, including, without limitation, earthquake insurance (subject to the provisions of subparagraph
(h) of the definition of Operating Expenses), as Landlord or Mortgagees may determine advisable. Tenant has no tight to receive any proceeds from any insurance policies carried by Landlord. Notwithstanding anything in the foregoing to the contrary;
however, Landlord may self-insure but only to the extent permitted under any Mortgage. 
  
 If any act or acts, occupancy or use by Tenant or any Tenant Parties, whether or not Landlord has consented to the same, increase the cost of Landlord’s insurance, Tenant will pay the fall cost of any such
increase along with Additional Rent. A schedule issued by the organization computing the insurance rate shall be conclusive evidence of the cost of such increase in premium. If any of Landlord’s insurance is (or is threatened to be) cancelled
or the coverage thereunder reduced ID any way because of any ad or acts, occupancy or use by Tenant or any Tenant Parties, Landlord may terminate this Lease and/or may enter upon the Premises at Tenant’s sole cost and expense and without any
liability to Tenant, and attempt to remedy such condition. Ali costs incurred by Landlord in performing any such remedial action shall be repaid by Tenant to Landlord within thirty (30) days after written demand, together with an administrative fee
equal to ten percent (10%) of such costs. 
  
 16. NO
SUBROGATION 
  
 Ali insurance policies which
either party obtains, or is required to obtain hereunder affecting the Premises shall include, if available from each party’s respective insurer upon commercially reasonable terms and prices, a clause or endorsement denying the insurer any
rights of subrogation against the other party. Landlord and Tenant waive any rights or recovery against the other for any actually insured injury or loss. 
  
 17. DAMAGE OR DESTRUCTION 
  
 If the Premises or any part thereof is damaged by fire or other casualty, Tenant will promptly notify Landlord. 
  
 17.1 Cancellation of Lease: Restoration of Building 

 
 If the Building or the Premises or any significant portion of the Common
Areas Is damaged by fire or other casualty to the extent that, in Landlord’s sole and absolute opinion, substantial alteration or reconstruction is required, or if any Mortgagee of a Mortgage requires that the insurance proceeds payable as a
result of the fire or other casualty be applied against the indebtedness secured by the Mortgage, Landlord may terminate this Lease by notifying Tenant within sixty (60) days after the later of the daft the damage occurs or the date Landlord is so
notified by its Mortgagee, in which event the Rent under this Lease will be equitably abated as of the date of the fire or other casualty to 
  

 -17- 

 the extent such damage materially impair Tenant’s business operations at the Premises. If this Lease is not
terminated, then within seventy-five (75) days after the fire or other casualty, or such greater period as may be reasonably necessary, Landlord will commence to repair and restore the Premises and any portion of the Building and Common Areas
required for access to the Premises, and will diligently complete the same, but Landlord shall not be required (a) to expend more for such repair of the Premises than the insurance proceeds in Landlord’s possession (or to be disbursed to
Landlord pursuant to the Mortgage) that exceed the proceeds retained (or required to be retained) by Mortgagee pursuant to its Mortgage and that are reasonably allocable to the Premises, or (b) to rebuild, repair or replace any of Tenant’s
furniture, furnishings, fixtures or equipment removable by Tenant under the provisions of this Lease or which Tenant has insured or is required to insure under the provisions of this Lease. If the Premises (or access thereto) are damaged by fire or
other casualty so as to unreasonably interfere with Tenant’s use and enjoyment of the Premises for Tenant’s normal business operations and Landlord reasonably determines that it will be unable to repair that portion of the Premises (or
access thereto) for which Landlord is responsible hereunder within two hundred seventy (270) days after such fire or other casualty, then Landlord shall deliver written notice to Tenant within sixty (60) days after such fire or other casualty
informing Tenant of Landlord’s inability to so repair the Premises (or access thereto) within said two hundred seventy (270) day period and Tenant shall have ten (10) days from the date of such notice during which to terminate this Lease by
delivering to Landlord written notice of Tenant’s desire to so terminate the Lease. If Tenant does not timely elect to so terminate this Lease, this Lease shall remain in full force and effect 
  
 17.2 Casually Loss During Last Year of Lease 
  
 If the Premises or the Building is damaged by fire or other casualty during
the last six (6) months of the Term, whether or not the damage requires substantial repair and reconstruction, either Tenant or Landlord may cancel this Lease as of the date of the fire or casualty by notice to the other within thirty (30) days
thereafter. 
  
 17.3 Abatement of Rent 

 
 In the event of any damage described in this Section 17, Base Rent shall
be equitably abated in proportion to the extent that Tenant’s business operations at the Premises are unpaired, such abatement to commence as of the date such damage occurs and will continue during the period of such repairs. Except as
expressly provided to the contrary in this Lease, this Lease will not terminate, and Tenant will not be entitled to damages or to any abatement of Rent, as a result of a fire or other casualty, repair or restoration. The provisions of California
Civil Code Sections 1932(2) and 1933(4) which permit termination of a lease upon destruction of Premises, and any other present or future statute that may so permit, are hereby waived by Tenant. 
  
 18. CONDEMNDATION 
  
 If all or substantially all of the Building or of the Premises or of the
parking areas in the Common Areas is taken for any public or quasi-public use under any governmental law, ordinance or regulation or by right of eminent domain or is sold to the condemning authority in lieu of 
  

 -18- 

 condemnation, then this Lease will terminate on the earlier of the date title thereto passes to the condemning authority
or when physical possession is taken by the condemning authority. If a lesser but material portion of the Building or Common Areas is thus taken or sole (whether or not the premises are affected thereby), then either Tenant (if the taking renders
the Building and the Premises unsuitable for Tenant’s continued use of the Premises) or Landlord may terminate this Lease by notice to the other within sixty (60) days after the taking or sale, in which event this Lease will terminate on the
earlier of the date title thereto passes to the condemning authority or when physical possession of the applicable portion of the Building, the Common Areas or the Premises is taken by the condemning authority. If this Lease is not terminated
pursuant to the foregoing and a portion of the Premises has been taken or sold, the Base Rent and Tenant’s Share shall be adjusted according to the Rentable Area of the Premises remaining after such taking or sale, and Landlord, at its sole
expense, will restore the affected portion of the Building to substantially its former condition as far as feasible, but not beyond the work done by Landlord in originally constructing the affected portion of the Building and installing tenant
improvements in the Premises. However, Landlord shall not be required to expend more for any restoration of the Premises than the Premises’ allocable share of the net compensation or damages received by Landlord for the part of the Building
taken and which compensation or damages have been or will be released to Landlord by Mortgagee. Landlord will be entitled to receive all of the compensation awarded upon a taking of any part or all of the Development, including, without limitation,
any aware for any unexpired term of this Lease and Tenant hereby assigns such compensation so awarded to Landlord. Notwithstanding the foregoing, Tenant may seek an award in separate proceedings for its personal property, trade fixtures, moving
expenses and good will. 
  
 In the event of a taking or sale of
the Premises or any part thereof for temporary use, this Lease shall remain unaffected and Rent shall not abate, and Tenant shall be entitled to such portion or portions of any award made for such use with respect to the period of the taking which
is within the Term, provided that, if such taking shall remain in force at the expiration or earlier termination of this Lease, Tenant shall then pay to Landlord a sum equal to the reasonable cost of performing Tenant’s obligations with respect
to surrender of the Premises. 
  
 To the extent that it is
inconsistent with the provisions of this Section 18, each party hereto hereby waives the provisions of Section 1265.130 of the California Code of Civil Procedure allowing either party to petition to court to terminate this Lease in the event of a
partial taking of the Premises. 
  
 19. DEFAULTS
AND REMEDIES 
  
 19.1
Events of Default 
  
 The occurrence of any one or more of
the following events shall constitute a default hereunder by Tenant: 
  

 -19- 

 (a) Tenant fails to make a payment within five (5) days after written notice that such payment is due
hereunder; provided, however, that Landlord shall not be required to provide such notice more than twice during the Term with respect to Base Rent or Additional Rent, the third such non-payment constituting default without requirement of notice; or

  
 (b) Tenant attempts any Assignment (as defined in Section 20)
except as expressly permitted pursuant to Section 20; or 
  
 (c)
Tenant fails to comply with any other obligation under this Lease and does not cure such failure as soon as reasonably practicable and in any event within twenty (20) days after written notice; provided, however, if such failure cannot be cured
during such twenty (20) day period, Tenant shall not be is default hereunder so long as Tenant commences to cure such failure within that twenty (20) day period and thereafter diligently completes such cure; or 
  
 (d) Tenant or any Guarantor becomes insolvent, makes a transfer in fraud of
creditors or an assignment for the benefit of creditors, admits in writing its inability to pay its debts as they become due, or files a petition under any Section or Chapter of the United States Bankruptcy Code or any similar law or statute; or an
order for relief is entered with respect to Tenant or any Guarantor in any bankruptcy, reorganization or insolvency proceeding; or a pleading seeking such an order is not discharged or denied within sixty (60) days after Its filing; or any action is
taken at the corporate, partnership or company level by Tenant or any Guarantor to authorize any of the foregoing actions on behalf of Tenant or any Guarantor, or a receiver or trustee is appointed for all or substantially all of the assets of
Tenant or any Guarantor or of the Premises or any of Tenant’s property located thereon in any proceedings brought by Tenant or any Guarantor, or any receiver or trustee is appointed in any proceeding brought against Tenant or any Guarantor and
not discharged within sixty (60) days after appointment or Tenant or any Guarantor does not contest such appointment; or any part of Tenant’s estate under this Lease is taken by process of law in any action against Tenant; or 
  
 (e) Tenant abandons the Premises; or 
  
 (f) Three (3) times within a year, Tenant fails to fulfill a monetary
obligation or a material nonmonetary obligation under this Lease but thereafter cures such failure within the time provided. 
  
 Any notice specified above shall serve as, and not be in addition to, any notice required under California Code of Civil Procedure Section 1161 or
otherwise regarding unlawful detainer actions. 
  
 19.2
Remedies 
  
 (a) Upon an event of default, Landlord shall
have the immediate option to terminate this Lease and all rights of Tenant hereunder by giving written notice- to Tenant of such termination. If and when this lease is so terminated, all rights of Tenant and those claiming under it will terminate
and Landlord may Immediately recover from Tenant: 
  

 -20- 

 (i) The worth at the time of award of any unpaid Rent which had been earned at the tune of such
termination; plus 
  
 (ii) The worth at the time of award of the
amount by which the unpaid Rent which would have been earned after termination until the time of award exceeds the amount of such rental loss that Tenant proves could have been reasonably avoided; plus 
  
 (iii) The worth at the time of award of the amount by which the unpaid Rent
for the balance of the term after the time of award exceeds the amount of such rental loss that Tenant proves could be reasonably avoided; plus 
  
 (iv) Any other amount necessary to compensate Landlord for all the detriment proximately caused by Tenant’s failure to perform Tenant’s
obligations under this Lease or which in the ordinary course of things would be likely to result therefrom. 
  
 As used in Subsections (i) and (ii) above, the “worth at the time of award” is computed by allowing interest at the maximum rate permitted by
law. As used in Subsection (iii) above, the “worth at the time of award” is computed by discounting such amount at the discount rate of the Federal Reserve Bank of San Francisco at the time of award plus one percent (1%). 
  
 (b) Pursuant to California Civil Code Section 1951.4, Landlord shall have the
right to continue this Lease in full force and effect and this Lease shall continue in full force and effect as long as Landlord does not terminate Tenant’s rights to possession of the Premises and Landlord shall have the right to collect Rent
when due. Until this Lease is so terminated, Landlord may, on Tenant’s behalf, at Tenant’s sole cost and expense and in Landlord’s sole discretion, sublet any of the Premises (and, on expiration or earlier termination of the sublease,
may re-sublet) for all or part of the remainder of the Term, on whatever terms and conditions Landlord in its sole and absolute discretion deems advisable. Against the Rent and sums due from Tenant to Landlord during the remainder of the Term,
credit will be given Tenant in the net amount of Rent received from the new tenant but only after deduction by Landlord for (a) the costs incurred by Landlord in reletting the Premises (including, without limitation, repair and remodeling costs,
brokerage fees, legal fees and the like), and (b) all accrued sums, plus interest and late charges, under the terms of this Lease. 
  
 (c) Upon an event of default or when Tenant is no longer entitled to possession, Landlord may enter the Premises and dispose of Tenant’s property in
accordance with law, and may perform Tenant’s obligations hereunder on Tenant’s behalf. Tenant will reimburse Landlord immediately on demand for Landlord’s attorneys’ fees and other expenses in doing so. This Section 19.2(c)
shall survive expiration or earlier termination of this Lease. 
  
 19.3 Continuing Liability 
  
 No repossession, re-entering or re-letting of the Premises or any part thereof by Landlord shall relieve Tenant or any Guarantor of its liabilities and
obligations under this Lease. 
  

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 19.4 Remedies
Cumulative 
  
 All
rights and remedies of Landlord under this Lease will be nonexclusive of and in addition to any other remedies available to Landlord at law or in equity. 
  
 19.5 No Waiver 
  
 Either party’s failure to insist on strict compliance with any terms hereof or to exercise any right or remedy, does
not waive the same. Waiver of any agreement regarding any breach does not affect any subsequent or other breach, unless so stated. A receipt by Landlord of any Rent with knowledge of the breach of any covenant or agreement contained in this Lease
shall not be a waiver of the breach, and no waiver by either party of any violation or provision of this Lease shall be effective hapless expressed in writing and signed by such party. Payment by Tenant or receipt by Landlord of a lesser amount than
due under this Lease may be applied to such of Tenant’s obligations as Landlord elects. No endorsement or statement on any check, and no accompanying letter, shall make the same an accord and satisfaction, and Landlord may accept any check or
payment without prejudice to Landlord’s right to recover the balance of the Rent or pursue any other remedy provided in this Lease. 
  
 20. ASSIGNMENT OR SUBLEASE 
  
 20.1 Notification 
  
 If Tenant intends to assign, transfer, or encumber this Lease or any estate
or interest herein, or permit the same to occur, or sublet or grant any right of occupancy for any part of the Premises or permit such occupancy by any other parties other than Tenant and any Tenant Parties, or modify or terminate any agreement for
any of the foregoing (the foregoing collectively referred to as an “Assignment,” and the other party thereto the “Assignee”), Tenant shall give Landlord written notice of such intent. Tenant’s notice shall be accompanied by
an exact copy of the proposed agreement between Tenant and the proposed Assignee. Tenant shall provide Landlord with (a) any additional information or documents reasonably requested by Landlord within ten (10) days after receiving Tenant’s
notice, and (b) an opportunity to meet and interview the proposed Assignee, if requested. 
  
 20.2 Landlord Approval 
  

Landlord shall then have a period of twenty (20) days following such interview and receipt of such additional information (or thirty (30) days from the
date of Tenant’s original notice if Landlord does not request additional information or an interview) within which to notify Tenant in writing that Landlord elects, in its sole and absolute discretion, either (a) to terminate this Lease as to
the space so affected as of the date so specified by Tenant, in which event Tenant will be relieved of all further obligations hereunder as to such space arising from and after such termination except for those obligations which by their terms
survive termination or earlier expiration of this Lease, or (b) to permit the Assignment, subject, however, to prior written approval of the proposed Assignee by Landlord, such consent not to be unreasonably withheld so long as (i) the use of the
Premises by such Assignee would be in accordance with Section 7.1 hereof, (ii) the proposed Assignee is of 
  

 -22- 

 sound financial condition as determined by Landlord in its good faith discretion, (iii) the Assignee would not cause the
violation of any covenant or agreement of Landlord to any third party or would permit any outer tenant to terminate its lease, and (iv) the Assignee does not then lease or occupy any other space In the Development. If Landlord fails to notify Tenant
in writing of its election within said period, Landlord shall be deemed to have waived option (a) above, but written approval by Landlord of the proposed Assignee shall nonetheless be required in accordance with (b) above. Failure by Landlord to
approve a proposed Assignee shall not cause a termination of this Lease. If Tenant’s obligations under this Lease have been guaranteed by one or more Guarantors, then an Assignment, and Landlord’s consent thereto, shall not be effective
unless the Guarantors give their written consent to such Assignment and the terms thereof and explicitly agree in writing that the Guaranty shall remain in full force and effect notwithstanding such Assignment. 
  
 20.3 Allocation of Excess
Rent 
  
 Any rent or other
consideration realized by Tenant under any Assignment in excess of the Rent payable hereunder, after amortization of the reasonable cost of the tenant improvements for which Tenant has paid and agar amortization of the reasonable Assignment costs,
shall be divided and paid as follows: (a) so long as after such Assignment, the original Tenant named herein shall occupy not less than seventy-five percent (75%) of the Rentable Area of the Premises, twenty-five percent 2%) to Tenant and
seventy-five percent (75%) to Landlord; and (b) in all other cases, ten percent (10%) to Tenant and ninety percent (90%) to Landlord. 
  
 20.4 Fair Market Rent 
  
 In any subletting undertaken by Tenant, Tenant shall diligently seek to obtain not less than Fair Market Rent for the space
so sublet. In any assignment of this Lease in whole or in part, Tenant shall seek to obtain from the assignee consideration reflecting a value of not less than Fair Market Raft for the space subjected to such assignment. Tenant shall provide
Landlord, upon Landlord’s demand, true and correct executed copies of the documents constituting such Assignment and any amendments thereof during the Term. 
  
 20.5 No Release from Liability 
  
 No Assignment by Tenant shall relieve Tenant or any Guarantor of any
obligation under this Lease or any Guaranty. Any Assignment that conflicts with the provisions hereof shall be void. No consent by Landlord to any Assignment shall constitute a consent to any other Assignment nor shall it constitute a waiver of any
of the provisions of this Section 20 as they apply to any such future sublettings or assignments. 
  
 20.6 Compliance with Laws 
  
 Any improvements, additions, or alterations to the Development that are required by any law, ordinance, rule or regulation,
or art deemed necessary or appropriate by Landlord as a result of any Assignment hereunder, shall be installed and provided by Tenant or the Assignee without cost or expense to Landlord. 
  

 -23- 

 20.7 Reimbursement of Costs 
  
 Landlord may time outside consultants to review all Assignment documents and
information. Tenant shall reimburse Landlord for the reasonable cost thereof, including reasonable attorneys’ foes, immediately on demand, but in no event shall Tenant be obligated to pay to Landlord more than One Thousand Five Hundred Dollars
($1,500.00). 
  
 20.8 Negotiation with
Assignee 
  
 Without liability to
Tenant, Landlord shall have the right to offer and to lease space in the Development, or in any other property, to any party, including, without limitation, parties with whom Tenant is negotiating, or with whom Tenant desires to negotiate,
concerning assignment or subletting the Premises, or any portion thereof. 
  
 20.9 Change Of Control; Affiliates 
  
 “Assignment” within the meaning of this Section 20 includes any change in control of Tenant or any Guarantor, or any sale of more than half the
assets of Tenant or any Guarantor outside the ordinary course of business. Tenant shall notify Landlord of any such change in control or sale prior to its consummation, and concurrently shall submit current financial statements applicable thereto,
all subject to Landlord’s reasonable consent and Landlord’s other rights under this Section 20, as in the case of any other Assignment. 
  
 Notwithstanding the foregoing, Landlord agrees that Tenant may enter into an Assignment, without Landlord’s consent, with any entity which controls,
is controlled by or is under common control with Tenant, or with any entity resulting from a merger or consolidation with Tenant, or with any person or entity which acquires all the assets of Tenant as a going concern in the business that is being
conducted on the promises, provided that, before such Assignment shall be effective, (a) the Assignee shall assume in writing, in full, the Obligations of Tenant under this Lease, (b) any Guarantor shall explicitly agree in writing that any Guaranty
shall remain in full force and effect notwithstanding such Assignment and (c) Landlord shall be given written notice of such assignment and assumption. Any such Assignment shall not, in any way, affect or limit the liability of Tenant or any
Guarantor under the terms of this Lease or any Guaranty, even if after such Assignment the term of this Lease is materially changed or altered without the consent of Tenant, the consent of whom shall not be necessary. As used in this Section 20.9,
control (including, with correlative meanings, the tams “controlled by” and “under common control with”) shall mean the possession, directly or indirectly, of the power to direct or cause the direction of management and policies,
whether through the ownership of voting securities or by contract or otherwise. 
  
 20.10 Conveyance by Landlord 
  
 Landlord may transfer, assign and convey all or any part of or interest in the Development or any of its rights under this Lease. If Landlord transfers,
assigns or conveys its rights under this Lease, it shall thereby be released from any further obligations under this Lease, Landlord’s 
  

 -24- 

 successors-in-interest shall be deemed to have assumed those obligations, and Tenant will attorn and look solely to
Landlord’s successor-interest for performance of those obligations. 
  
 21. SUBORDINATION 
  
 This Lease
and all rights of Tenant under this Lease are subject and subordinate to any of the following, and any modifications thereof; which may now or hereafter affect any portion of the Development (a) any Mortgage, or any ground or underlying lease
covering any part of the Development, provided that the Mortgage holder or ground lessor shall agree that Tenant’s peaceable possession of the Premises will not be disturbed on account of such subordination so long as Tenant is not in default
under this Lease and attorns to such Mortgage holder or ground lessor, (b) any applicable laws, rules, statutes and ordinances of any governmental authority having jurisdiction, and (c) all utility easements and agreements. On sale by foreclosure of
a Mortgage or sale in lieu of foreclosure, Tenant will attorn to the purchaser if requested by such purchaser, and recognize the purchaser as the Landlord under this Lease. These provisions are self-operative and no further instrument is required to
effect them; however, upon demand from time to time, Tenant shall execute, acknowledge and deliver to Landlord any commercially reasonable instruments and certificates necessary or proper to evidence such subordination and/or attornment or, if
Landlord so elects, to render any of the foregoing subordinate to this Lease or to any or all rights of Tenant hereunder. Tenant further waives the provisions of any current or future statute, rule or law which may give or purport to give Tenant any
right or election to terminate or otherwise adversely affect this Lease and the obligations of Tenant hereunder in the event of any such foreclosure proceeding or sale, and agrees that this Lease shall not be affected in anyway whatsoever by any
such proceeding or sale unless the Mortgagee, or the purchaser, shall declare otherwise. 
  
 22. ESTOPPEL CERTIFICATE 
  
 Promptly upon no less than ten (10) days after Landlord’s prior written request, Tenant will from time to time execute and deliver to Landlord a certificate, substantially in the form attached hereto as Exhibit
D, certifying: (i) the date of commencement of this Lease; (ii) the fact that this Lease is unmodified (except as the certificate specifics) and in full force and effect; (iii) the date to which the sums payable under this Lease have been paid; (iv)
that there are no current defaults under this Lease by either Landlord or Tenant except as specified, and (v) such other matters as Landlord requests. This certification may be relied upon by any actual or prospective Mortgagee or purchaser of all
or part of the Development or any interest therein or in Landlord. Failure to so execute and deliver said certificate will be conclusive upon Tenant (i) that this Lease is in full force and effect without modification except as may be represented by
Landlord, (ii) that there are no uncured defaults in Landlord’s performance, and (iii) that no more than one (1) month’s rental bas been paid in advance; and Tenant irrevocably authorizes Landlord, as Tenant’s attorney-in-fact and in
Tenant’s name, to so execute and deliver said certificate, Landlord shall deliver to Tenant, from time to time upon no less than ten (10) days after Tenant’s prior written request, a certificate in a form similar to that described herein
and reasonably acceptable to Landlord. 
  
 23. INTENTIONALLY
DELETED 
  

 -25- 

 24. SURRENDER OF PREMISES 
  
 Upon expiration or earlier termination of this Lease, Tenant will surrender
the Premises to Landlord in as good repair and condition as when Tenant first occupied, except for reasonable wear and tear, and for damage or destruction by fire or other casualty or any condemnation for which Tenant is not responsible or liable
under this Lease. Tenant will concurrently deliver to Landlord all keys to the Premises, and restore any locks which it has charged to the system which existed at the commencement of the Term. If possession is not immediately surrendered, Landlord
may enter upon and take possession of the Premises and expel or remove Tenant and any other person who may be occupying the Premises or any part thereof. Tenant acknowledges that Landlord will be attempting to lease the Premises with any such lease
to be effective upon expiration of the Term, and failure to surrender the Premises could cause Landlord to incur liability to such successor tenant for which Tenant shall be responsible hereunder to the full extent thereof. 
  
 24.1 Leasehold Improvements and
Fixtures 
  
 At the
expiration or earlier termination of this Lease, Landlord may require the removal of any or all Alterations, above-Standard Tenant Improvements, personal property and equipment from the Premises, and the restoration of the Premises to its condition
prior to installation of such items, except for reasonable wear and tear, and for damage or destruction by fire or other casualty or any condemnation for which Tenant is not responsible or liable under this Lease, at Tenant’s sole cost and
expense; provided that. Landlord so notified Tenant in accordance with Section 10.2 of this Lease. Unless Landlord requires their removal pursuant to this Lease, all Alterations and above-Standard Tenant Improvements made to the Premises shall
remain upon and be surrendered with the Premises at the expiration or earlier termination of this Lease. All personal property and equipment on or about the Premises, other than that which is affixed to the Premises so that it cannot be removed
without material damage to the Premises or the Building, shall be removed from the Premises by Tenant at the expiration or earlier termination of this Leases All removals by Tenant will be accomplished in a good and workmanlike manner so as not to
damage any portion of the Building, and Tenant will promptly repair and restore all damage done. If Tenant does not so remove any property which it has the right or duty to remove, Landlord may immediately either claim it as abandoned property, or
remove, store and dispose of it in any manner Landlord may choose, at Tenant’s cost and without liability to Tenant or any other party. The provisions of this Section shall survive the expiration or earlier termination of this Lease.

  
 24.2 Holding
Over 
  
 If Tenant does not surrender
the Premises as required and holds over after its right to possession ends, Tenant shall become a tenant at sufferance only, at a monthly rental rate equal to one hundred fifty percent (150%) of the total Rent payable in the last prior full mouth,
without renewal, extension or expansion rights, and otherwise subject to the terms, covenants and conditions herein specified, so far as applicable. Nothing other than a fully executed written agreement of the parties creates any other relationship.
Tenant is liable for Landlord’s loss, costs and damage from such holding over, including, without limitation, those from Landlord’s delay in delivering possession to other parties. These provisions are in addition to other rights of
Landlord hereunder 
  

 -26- 

 and as provided by law. The provisions of this Section shall survive the expiration or earlier rumination of this Lease.

  
 25. PROFESSIONAL FEES 
  
 Each party shall be entitled to reasonable attorneys’ fees and all
other costs and expenses incurred in the preparation and service of notices of default and consultations in connection therewith, whether or not a legal action is subsequently commenced in connection with such default In any dispute between the
parties (whether or not litigated) arising hereunder or out of Tenant’s use or occupancy of the Premises, the prevailing party’s reasonable costs and expenses (including fees of attorneys and expenses) will be paid or reimbursed by the
unsuccessful party. As used herein, “prevailing party” shall meats the party who substantially prevails in the matter at issue, including without limitation, a party who dismisses an action for recovery hereunder in exchange for payment of
the sums allegedly due, performance of covenants allegedly breached or consideration substantially equal to the relief sought in the action. The provisions of this Section shall survive the expiration or earlier termination of this Lease.

  
 26. GENERAL PROVISIONS 
  
 26.1 Mortgage Protection

  
 Tenant shall not sue Landlord for damages or exercise
any right to terminate until (a) it gives written notice to any Mortgagee whose name and address have been furnished to Tenant, and (b) a reasonable time (but in no event more than thirty (30) days following receipt of such notice or such additional
time as is reasonably required) for such Mortgagee, at its option, to remedy the act or omission giving rise to such suit has elapsed following the giving of the notice, without the same being remedied. During that time, Landlord shall not be
considered in default, and Landlord and/or any Mortgagee and/or their employees may enter the promises in accordance with Section 12 and do therein whatever may be necessary to remedy the act or omission, it being agreed that no Mortgagee shall have
any obligation to Tenant to cure or remedy any act or omission of Landlord. 
  
 26.2 Successors and Assigns 
  
 Subject to Section 20 hereof, this Lease shall inure to the benefit of and bind all parties hereto and their respective successors and assigns.

  
 26.3 Waiver

  
 Tenant waives any right it may now or hereafter have
(a) to redeem the Premises or to have a continuance of this Lease after expiration or earlier termination of this Lease, (b) for exemption of property from liability for debt or for distress for rent, or (c) relating to notice or delay in levy of
execution in case of eviction for nonpayment of rent. 
  

 -27- 

 26.4 Identification of Tenant 
  
 If there is more than one party constituting Tenant or any Guarantor, their
obligations are joint and several, and Landlord need not first proceed against any of them before proceeding against the others, nor shall any Guarantor be released for any reason whatsoever, including, without limitation, any amendment of this
Lease, any forbearance by Landlord or waiver of any of Landlord’s rights, the failure to give any party constituting Tenant or any Guarantor any notices, or the release of any party liable for the payment of Tenant’s obligations. If there
is more than one party constituting Tenant, any of them acts for all others in every regard with respect to this Lease (including, but not limited to, any renewal, extension, expiration, termination or modification). 
  
 26.5 Parking

  
 Tenant shall be entitled to nonpreferential and
nonexclusive use of the number of parking spaces in the Common Areas specified in the Lease Summary, for which right Tenant will pay the monthly fee per space that Landlord sets from time to time for each type of space, plus any tax or assessment
imposed by any governmental authority in connection with the parking privileges provided to Tenant pursuant to this Lease. Said monthly fees shall be paid whether or not Tenant uses said spaces; provided, however, that Landlord hereby waives its
right to collect such parking fees from Tenant for the spaces during the initial term of this Lease, except to the extent that Landlord is required to impose a parking fee by any governmental regulation now or hereafter applicable to any part or all
of the Development, or to Landlord or Tenant Landlord may assign any unreserved and unassigned parking spaces and/or make all or a portion of such spaces reserved, if it determines in its sole discretion that it is necessary for orderly and
efficient parking. Landlord at any time may substitute an equivalent number of parking spaces in a parting structure or subterranean parking facility or in a surface parking area within a reasonable distance of the Premises. 
  
 26.6 Interpretation of Lease

  
 Tenant acquires no rights by implication from this
Lease, and is not a beneficiary of any past, current or future agreements between Landlord and third parties. Surrender or cancellation of this Lease shall not work a merger, and shall, at Landlord’s sole option, either terminate all existing
subleases or subtenancies or shall operate as an assignment to Landlord of all such subleases or subtenancies. The delivery of keys to Landlord or any Landlord Party is not a termination of this Lease or a surrender of the Premises. 
  
 Headings in this Lease are for convenience only, and do not affect the
meaning of the text. Unless the context indicates otherwise, words of any gender or grammatical number include all genders and numbers. Where the context conflicts with the definition of any term, the context will control, but only for that purpose
and related purposes. If any provision of this Lease or any application thereof is invalid, void or illegal, no other provision or application shall be affected. 
  

 -28- 

 California law governs this Lease. Neither party may record this Lease or a copy or memorandum thereof.
Submission of this Lease to Tenant is not an offer, and Tenant will have no rights hereunder until each party executes a counterpart and delivers it to the other party. As used herein, the word “including” shall be construed to mean
“including, without limitation.” 
  
 26.7
Limitation on Liability 
  
 Landlord’s rights hereunder are solely for Landlord’s benefit, and Landlord has no duty to exercise them for the benefit of Tenant or others. Any liability of Landlord and the Landlord Parties to Tenant and
the Tenant Parties under this Lease, or arising from the relationship under it, is limited to the interest of Landlord in the building, and no personal liability shall at any time be asserted or enforceable against Landlord or Landlord Parties on
account of Landlord’s or Landlord Parties’ obligations or actions under this Lease. If Tenant proposes any action which requires Landlord’s consent and such consent is impermissibly withheld, denied or delayed, Tenant may only seek an
injunction or specific performance but shall not be entitled to damages therefor, including, without limitation, consequential or incidental damages or lost profits. 
  
 26.8 Traffic Impact 
  
 Traffic control and flow is a major concern of local government, of Landlord
and of each tenant in the Building and surrounding buildings. Tenant will cooperate with Landlord in reasonable efforts to alleviate the traffic impact of the Development on the local area streets and highways. 
  
 26.9 Financial Statements

  
 Tenant represents, warrants and covenants that
financial statements heretofore or hereafter furnished to Landlord, in connection with this Lease, are accurate and are not materially misleading. At anytime during the Term, Tenant shall, upon ten (10) days prior written notice, provide Landlord
with a current financial statement and financial statements of the two (2) years prior to the current financial statement year, and prepared in accordance with generally accepted accounting principles and, if such is Tenant’s normal practice,
audited by an independent certified public accountant. 
  
 26.10 Quiet Enjoyment 
  
 If Tenant pays all sums and performs all its other obligations under this Lease, Tenant shall and may peaceably and quietly have, hold and enjoy the Premises against all persons claiming any rights or interest in or
to the Premises by or through Landlord, subject to this Lease and to rights to which this Lease is subordinate. Tenant acknowledges that the Building and the general area in which the building is located is subject to sight, sound and overflight by
general aviation aircraft. 
  
 26.11
Payments and Notice 
  
 Any notice or document shall be considered delivered whether actually received or not, on the third day after deposit in the United States mail, postage prepaid, registered or certified mail, return receipt requested, addressed to the
parries hereto at the respective addresses set forth on the 
  

 -29- 

 Lease Summary or at such other address as the party to be notified may from time to time designate by at least fifteen
(15) days’ prior written notice delivered in accordance with this Section 26.11 to the notifying parties, or when personally delivered to that address; except that if such day is not a business day, the notice or document will be considered
delivered on the neat business day. All payments required to be made by Tenant to Landlord are to be paid, without prior demand except as may be expressly specified herein and without any setoff, deduction or counterclaim whatsoever, except as may
be expressly specified herein, in legal tender of the United States of America at the address set forth on the invoice or, if no invoice is submitted or no address is set forth at the address for the landlord set forth on this Lease or at any other
address as Landlord may specify from time to time by written notice is accordance with this Section 26.11. Any amounts overdue from Landlord or Tenant hereunder shall accrue interest from the date due at the Prime Rate plus four percent (4%) per
annum, but in no event more than the legally permissible rate. If Tenant is late in the payment of Base Rent and/or Additional Rent for two (2) consecutive months, Landlord may require Tenant to pay Base Rent and/or Additional Rent in advance on a
quarterly basis. If any check or other payment device is returned due to insufficient funds or any other reason, Landlord may require all future payments to be made by money order or cashier’s check. 
  
 26.12 Late Charge

  
 If any amounts due hereunder from Tenant are not
received by Landlord within five (5) days after said amounts are due, Tenant shall also pay to Landlord a late charge of five percent (5%) of all such past due amounts, for which the parties agree is a fair and reasonable estimate of the extra costs
(including, without limitation, processing and accounting charges) Landlord will incur by reason of the late payment. Acceptance of any Tare charge shall not constitute a waiver of Tenant’s default with respect to such overdue, amount, or
prevent Landlord from exercising any of its other rights and remedies. 
  
 26.13 Rules and Regulations 
  
 Tenant and the Tenant Patties shall comply with the Rules and Regulations. 
  
 26.14 Rights Reserved by Landlord 
  
 In addition to other rights retained or reserved, Landlord reserves the following rights, exercisable without notice and
without liability to Tenant and without effecting an eviction, constructive or actual, or in any way diminishing Tenant’s obligations: (a) to change the name or street address of the Development or any part thereof (b) to install, affix and
maintain, modify or remove any and all signs on the exterior and interior of the Building or any other part of the Development; (c) to designate and approve, prior to installation, all types of interior and exterior window treatments and to control
all internal lighting that may be visible from the exterior of the Building; (d) the exclusive right to designate, limit, restrict and control any business and any service in or to the Building or its tenants or to any other part of the Development;
(e) to keep, and to use in appropriate instances, keys to all doors within and into the Premises (no locks shall be changed or added without the prior written consent of Landlord); (f) to decorate and make repairs, alterations, additions, changes or
improvements whether structural or otherwise (specifically including, without 
  

 -30- 

 limitation, those in conjunction with Landlord’s construction of additional buildings) in and about any pad of the
Development and to enter the Premises t accordance with Section 12 of this Lease for these purposes and, during such work to temporarily close doors, entryways. public space and corridors in the Development to interrupt or temporarily suspend
Building services and facilities and to change the arrangement and location of entrances or passageways, windows, doors and doorways, corridors, elevators, stairs, toilets, or other public parts of the Development; (g) to approve the weight, size
and location of safes and other heavy equipment and articles in and about the Premises and-the Building, and to require all such items and furniture to be moved into and out of the Building and Premises only at times and in such manner as Landlord
directs (movement of Tenant’s property is entirely at the risk and responsibility of Tenant, and Landlord reserves the right to require permits before allowing airy property to be moved into or out of the Building); (h) to have access for
Landlord and other tenants of the Building to any mail chutes located on the Premises according to the rules of the United States Postal Service; and (t) to take all reasonable measures Landlord considers advisable for the security of the
Development and its occupants. 
  
 26.15 Related Parties

  
 Where either party agrees not to do a particular
thing, it also agrees not to permit its Related Parties to do so. Where either party waives rights against the other party, it also waives the same rights against the other party’s Related Parties. That waiver shall be considered a waiver on
behalf of the party making it, of all that party’s Related Parties, and of anyone claiming under any of them, including insurers and creditors. 
  
 26.16 Landlord’s Costs 
  
 Where Tenant is required to pay or reimburse Landlord for the costs of any item, the cost shall be the reasonable and customary charge established by
Landlord from time to time, including a reasonable allocation of Landlord’s overhead, administrative and related costs associated with the ownership and operation of the Development Failure to pay any reimbursable cost shall be treated as a
failure to pay Rent. In connection with any request by Tenant for the consent of Landlord to an Alteration, Assignment or other act proposed by Tenant under this Lease, Tenant shall pay Landlord’s reasonable costs and expenses incurred in
connection therewith, including, without limitation, attorneys’, architects’, engineers’ and other consultants’ fees. 
  
 26.17 Invoices 
  
 The parties hereto agree that each party will promptly notify the other party of any dispute such party may have regarding any Invoice from the other
party. If either party does not so notify the other party within thirty (30) days after receiving any such invoice, such party shall be conclusively deemed to have agreed to such invoice and all underlying facts. 
  

 -31- 

 26.18 Force Majeure; Time of Essence 
  
 When a period of time is herein prescribed for action to be taken by either
party (excluding the payment of money by Tenant under this Lease), such party shall not be liable or responsible for, and there is excluded from the computation for any such period of time; any delays due to strikes„ riots, acts of God,
shortages of labor or materials, war, governmental laws, regulations or restrictions or any other cause of any kind whatsoever which is beyond the control of such party. Subject to the preceding sentence, time is of the essence of every part of this
Lease. 
  
 26.19 Negotiated Transaction 

 
 The parties mutually acknowledge that this Lease has been negotiated at
arm’s length. The provisions of this Lease shall be deemed to have been drafted by all of the parties and this Lease shall not be interpreted or construed against any party solely by virtue of the fact that such party or its counsel was
responsible for its preparation. 
  
 26.20 Nondisturbance,
Attornment and Subordination Agreement 
  
 Upon
Landlord’s request, Landlord, Tenant and Landlord’s Mortgagee shall execute, acknowledge (notarize) and deliver a Non-Disturbance, Attornment and Subordination Agreement (the Non-Disturbance Agreement”) substantially in the form
attached to this Lease as Exhibit F. Tenant shall not record the Non-Disturbance Agreement or a copy or memorandum thereof. 
  
 26.21 Nondiscrimination 
  
 Tenant herein covenants by and for himself or herself, his or her heirs, executors, administrators and assigns, and all persons claiming under or through
him or her, and this Lease is made and accepted upon and subject to the following conditions: That there shall be no discrimination against; of segregation of, any person or group of persons on account of race, color creed, religion, sex, marital
status, national origin or ancestry in the leasing, subleasing, transferring, use’ occupancy, tenure or enjoyment of the Premises herein leased, nor shall Tenant, or any person claiming under or through him or her, establish or permit any such
practice or practices of discrimination or segregation with reference to the selection, location, number, use or occupancy of tenants, lessees, subtenants, sublessees or vendees in the Premises herein leased. 
  
 26.22 Corporate Authority 
  
 If either party signs as a corporation, limited liability company, or
partnership, each of the persons executing this Lease on behalf of such party does hereby covenant and warrant that such party is a duly authorized and existing entity, that such party has and is qualified to do business in the State of California,
that the entity has full right and authority to enter into this Lease, and that each and both of the persons signing on behalf of the entity are authorized to do so. 
  

 -32- 

 26.23 Notice Pursuant to California Health do Safety Code Section 25359.7 
  
 In 1981-82, the Development was the subject of a state-supervised cleanup of
hazardous waste disposed of on the site by prior occupants. As part of the cleanup approved by the applicable agencies, some soils containing heavy metals were left in place, covered by clean fill. These soils are managed in accordance with the
requirements of the applicable agencies and a Declaration of Covenants, Conditions and Restrictions imposed by Homart Development Co. 
  
 26.24 Entire Agreements; Amendments 
  
 THIS LEASE CONTAINS ALL AGREEMENTS OF THE
PARTIES CONCERNING THIS SUBJECT MATTER, SUPERSEDING ANY SUCH PRIOR AGREEMENTS,
REPRESENTATIONS OR WARRANTIES, AND MAY BE AMENDED OR MODIFIED ONLY BY A
WRITTEN AGREEMENT SIGNED BY BOTH PARTIES. 
  
 [The balance of this page is intentionally left blank] 
  
  

 -33- 

 THIS LEASE SHALL NOT BE
BINDING UPON OR ENFORCEABLE BY EITHER PARTY UNTIL FULLY EXECUTED BY
BOTH LANDLORD AND TENANT. 
  
 IN WITNESS WHEREOF, the parties have executed this Lease as of the date fast above written. 
  

	Landlord	 	 HMS OFFICE, L.P.,
 a Delaware
limited partnership

			
	 	 	By:	 	Himes Office Company, L.L.C.
			
	 	 	Its:	 	General Partner
			
	 	 	By:	 	/s/    TOM OWENS
	 	 	 	

			
	 	 	Name:	 	Tom Owens
			
	 	 	Title:	 	Manager
		
	Tenant	 	 ELAN PHARMACEUTICALS, INC.
 a Delaware corporation

			
	 	 	By:	 	/s/    JOHN VARIAN
	 	 	 	

			
	 	 	Name:	 	John Varian
	 	 	 	

			
	 	 	Title:	 	Sr. Vice President, Finance & Administration
	 	 	 	

			
	 	 	By:	 	/s/    DONALD JOSEPH
	 	 	 	

			
	 	 	Name:	 	Donald R. Joseph
	 	 	 	

			
	 	 	Title:	 	Vice President, Commercial & Legal Affairs
	 	 	 	

 EXHIBIT A 
  
 THE GATEWAY 
  
 FLOOR PLAN 
  
  

 A-1 

 EXHIBIT A-1 
  
 THE GATEWAY 
  
 LEGAL DESCRIPTION 
  
 Beginning At A Point On Gateway Boulevard Common To Lots 1 And 4 As Said Boulevard And Lots Are Shown On Said Map; Thence Along The Line
Common To Said Lots The Following Courses And Distances: N 51 17’ 19”, W 50.00 Feet; Thence On A Curve To The Right Having A Radius Of 200.00 Feet Through A Central Angle Of 53 02’26” An Arc Distance Of 185.15 Feet; Thence On A
Curve To The Left Having A Radius Of 200.00 Feet Through A Central Angle Of 53 02’26” An Arc Distance Of 185.15 Feet; Thence N 51 17119” W 227.38 Feet To The Southeasterly Line Of Industrial Way As Shown On Said Map; Thence Along Said
Southeasterly Line N 38 42’41” E 1208.04 Feet; Thence Continuing Along Said Southeasterly Line N 38 42’27” E 6550 Feet To The Western Corner Of Lot 9 As Shown On Said Map; Thence Along The Line Common To Said Lots 1 And 9 S 51
17’19” E 930.00 Feet To The Northwesterly Line Of Said Gateway Boulevard; Thence Along Said Line Of Gateway Boulevard The Following Courses And. Distances; 
  
 S 38 42’41” W 79.14 Feet; 
 Thence S
63 42’41” W 5.92 Feet; 
 Thence S 38 42’41” W 100.00 Feet; 
 Thence S 13 42’41” W 5.92 Feet; 
 Thence S 38 42’41” W 148.64 Feet; 
 Thence Along A Curve To The Right Having A Radius Of 703.00 Feet through A Central Angle Of 27 22’20” An Arc Distance 335.85 Feet; 
 Thence S 66 05’01” W 359.00 Feet; 
 Thence Along A Curve To The Left
Having A Radius Of 797.00 Feet Through A Central Angle Of 27 22’20” An Arc Distance Of 380.76 Feet; 
 Thence S 38 42’41” W 55.00 Feet To
The Point Of Beginning Of This Description. 
  
 Containing A 24.160 Acres, More Or
Less. 
  

 A-1-1 

 EXHIBIT B 
  
 SAMPLE FORM OF 
  
 LEASE COMMENCEMENT CERTIFICATE

  
 OFFICE BUILDING 

 
 Re: The Gateway 
 651 Gateway Boulevard, Suite 950 and Suite 980 
 So. San Francisco, CA 94080 
  
 This is to certify that Elan Pharmaceuticals, Inc, a Delaware corporation,
Suite 950 and Suite 980, has opened/closed on             [Date]            . 
  

	BILLING
ADDRESS                                       
                         	 	Rentable
Area                                       
                                     
	 	 	Lease Commencement
	NAME                                      
                                        
              	 	Date
	ADDRESS                                     
                                        
       	 	Lease Expiration Date
	CITY, STATE,
ZIP                                       
                             	 	Rental Payment Commencement Date
	ATTN:                                     
                                        
               	 	Final Taunt Construction
	ATTN:                                     
                                        
               	 	Overage
		
	 	 	Payment due from Tenant
	 	 	Insurance Certificate
	 	 	submitted (YIN)
	 	 	Security Deposit received
	By:                                      
                                        
                     	 	By:                                      
                                        
                   
	Agent for Elan Pharmaceuticals, Inc.	 	Agent For HMS OFFICE, L.P.

  
  

 B-1 

 EXHIBIT C 
  
 THE GATEWAY 
  
 STANDARDS FOR UTILITIES AND SERVICES

  
 1. Elevators. Provide nonattended passenger
elevators to and from the floor(s) on which the Premises are located, Landlord may Limit the number of elevators operating outside normal business hours. 
  
 2. HVAC. On Monday through Friday, except holidays, from 7:00 am. to 6:00 p.m., ventilate the Premises and furnish air conditioning or heating on
such days and hours, in temperatures and amounts which in Landlord’s good faith judgment are reasonably required for comfortable occupancy of the Premises under normal business operations. If Tenant requires air conditioning during other hours,
Landlord will furnish same through an access system provided to Tenant at the Premises, if available, or otherwise as specified in a written request of Tenant delivered to the Building management office before coon on the preceding business day. For
this service Tenant will pay Landlord, upon receipt of Landlord’s statement, the charge at an hourly rate determined by Landlord from time to time, which is currently $30.00 per hour. Tenant agrees that neither Tenant nor any Tenant Party shall
at any time enter mechanical installations or facilities of the Building or adjust, tamper with, touch or otherwise in any manner affect said installations or facilities. The cost of maintenance and service calls to adjust and regulate the air
conditioning system shall be charged to Tenant if the need for maintenance work results from either Tenant’s adjustment of room thermostats or Tenant’s failure to comply, with Landlord’s rules governing the temperature within the
Premises. 
  
 3. Lighting. Furnish electric lighting for
all public areas and special service areas of the Building as Landlord determines in good faith to be reasonable and standard, including replacement of Building standard lights, bulbs and tubes. 
  
 4. Electrical Service. Subject to the limitation of this Paragraph 4,
furnish electrical service to the Premises, including providing and installing all Building standard replacement lighting tubes. If Tenant uses more electrical power than Landlord in good faith considers reasonable or normal for office use, Tenant
will pay Landlord on a monthly basis the cost of such excess power consumed by Tenant. Consumption will be determined, at Landlord’s election, either (a) by a survey perforated by a reputable consultant selected by Landlord, or (b) through
separate meters or submeters installed, maintained and read by Landlord at Tenant’s cost. For purposes of this Paragraph 4 only, “month” and “monthly” shall mean any billing period used by the utility or other power provide
supplying electricity. All installations of electrical fixtures, appliances and equipment within the Premises shall be subject to Landlord’s prior approval, and if they affect the temperature or humidity otherwise maintained, Landlord may, at
Tenant’s sole cost and expense (to be paid within (30) days after delivery of written demand supported by invoices or other reasonably satisfactory evidence), install supplemental air conditioning units. Tenant’s use of electricity shall
never exceed Tenant’s share of the capacity of existing feeders to the Building or of the risers, wiring installations and transformers serving the flows) containing the Premises. Landlord shall 
  

 C-1 

 provide up to 3.5 watts per usable square foot (demand) of riser and floor panel electrical capacity averaged over the
floor being serviced. Tenant shall be allocated an approximate 2.0 watts per usable square foot for power and 1.5 watts per usable square foot for lighting. Any risers or wiring necessary to meet Tenant’s excess electrical requirements will be
installed by Landlord on Tenant’s request, at Tenant’s sole cost and expense (to be paid in advance), but only if in Landlord’s good faith belief they are necessary and will not cause damage to the Building or a dangerous condition,
entail excessive or unreasonable alterations, repairs or expense, or disturb other occupants. 
  
 5. Water. Provide toilet facilities, water for lavatory and toilet purposes, cold water for drinking and tepid water for lavatory purposes, all at points of supply provided for general use of tenants in the
Building through fixtures installed by Landlord or by Tenant with Landlord’s consent. 
  
 6. Janitorial. Provide janitorial service to the Premises on business days and other cleaning services as Landlord determines to be reasonably required. Tenant will pay Landlord the full cost attributable to
any extraordinary janitorial or cleaning services which the Premises may require. 
  
 7. Maintenance of Non-Building Standard Items. Maintenance and service costs necessary for non-building standard items in the- Premises shall be the responsibility of Tenant: As used in this paragraph,
non-building standard items shall include, without limitation, heat pumps, condenser pumps, sinks and associated drain pipes, faucets, hot water heaters, garbage disposals, dishwashers, refrigerators, ice makers, air conditioning units, projection
screens and associated wiring and switching, incandescent downlight or wallwash fixtures and lamps, floor electrical outlets and power poles. 
  
 8. Security Services. Provide Building security personnel twenty-four (24) hours per day, seven (7) days per week, fifty-two (52) weeks per year
and a card access system which allows access to individual office floors twenty-four (24) hours per day, seven (7) days per week, fifty-two (52) weeks per year, all of which shall be provided by Landlord in its sole and absolute discretion.
Notwithstanding Landlord’s providing security, Tenant waives any claim against Landlord with respect to any loss by theft or any other damage suffered or incurred by Tenant in connection with any entry into the Premises or any other breach of
security with respect to the Premises or the Building except due to the gross negligence or willful misconduct of Landlord. 
  
 Landlord reserves the right to adopt reasonably, nondiscriminatory modifications and additions to these standards, which Landlord shall promptly deliver
to Tenant is writing. 
  

 C-2 

 EXHIBIT D 
  
 SAMPLE FORM OF 
 TENANT ESTOPPEL CERTIFICATE 
  
 Elan Pharmaceuticals, Inc., a Delaware corporation (“Tenant’) hereby certifies to
             as follows: 
  
 1. Attached hereto is a true, correct and complete copy of a lease dated,              1999, between Landlord and Tenant (the “Lease”),
which demised premises located at 651 Gateway Boulevard, Suite 950 and Suite 980, South San Francisco, California 94080 (“ Property”). The Lease is now in full force and effect and has been amended, modified, supplemented, extended,
renewed or assigned by and only by the following described agreements, copies of which are attached hereto (if none, so indicate), all of which (together with the Lease) are hereby ratified: 
  
                                       
                                       
  
                                       
                                       
  
 2. The term of this Lease commenced on
            , 1999 and will expire on             , 200    . 
  
 3. Tenant has accepted and is now in possession of said premises. 

 
 4. Tenant and Landlord acknowledge [that the Lease will be assigned to
             and] that no modification, adjustment, revision or cancellation of the Lease or amendments thereto shall be effective unless written consent of
             is obtained, and that until further notice, payments under the lease may continue as heretofore. 
  
 5. The amount of fixed monthly rent is $            
Tenant is paying in full lease rental which has been paid in full as of the data hereof. No rent under the Lease has been paid for more than thirty (30) days in advance of its due date. 
  
 6. The amount of security deposit held by Landlord (if any) is
$            . No other security deposits have been made. 
  
 7. All work required to be performed by Landlord or Tenant under the Lease has been performed, except for the following (if none, so indicate)
            . 
  
 8. There are no defaults on the part of the Landlord or Tenant under the Lease, except for the following (if none, so indicate)             .

  
 9. Tenant has no defense as to its obligations under the Lease
and claims no setoff or counterclaim against Landlord, except for the following (if none, so indicate)             . 
  

 D-1 

 10. Tenant has no right to any concession (rental or otherwise) or similar compensation in connection
with renting the space it occupies except as provided in the Lease, except for the following (if none, so indicate)             . 
  
 The foregoing certification is made with the knowledge that
             is about to (fund a loan to) (purchase the Property from) Landlord and that said party is relying upon the representations herein made in (finding such loan) (making
such purchase). 
  
 Dated:
            , 19         
  

	 TENANT: Elan Pharmaceutical, Inc.,
 a Delaware corporation

		
	By:	 	 
	 	

		
	Name:	 	 
	 	

		
	Title:	 	 
	 	

		
	By:	 	 
	 	

		
	Name:	 	 
	 	

		
	Title:	 	 
	 	

  

 D-2 

 EXHIBIT E 
  
 THE GATEWAY 
  
 RULES AND REGULATIONS 
  
 1. Signs. Except as specifically provided in this Lease to which these
rules and regulations are attached, no sign, placard, picture, advertisement, name or notice shall be installed or displayed on any part of the outside or inside of the Building or on the Common Areas or other areas of the Development without
Landlord’s prior written consent. Landlord may remove, at Tenant’s expense and without notice, any sign installed or displayed in violation of this rule. All signs or lettering on doors and walls must be approved by Landlord, and shall be
printed, painted, affixed or inscribed or modified at Tenant’s expense by a person approved by Landlord. Without Landlord’s written consent, Tenant shall not use the name of the Building or the Development in connection with or in
promoting or advertising the business of Tenant except as Tenant’s address. Landlord and Tenant acknowledge that the existing signage on the monument located on the Development next to the Building is to be removed and, subject to the
provisions of this Lease, Tenant shall have the right to place signage on the monument, at its sole expense, until such time that the monument is removed. Landlord hereby agrees to provide Tenant with the Building’s standard graphics at the
entrance to the Premises and in the elevator lobby. 
  
 2.
Window Treatments. Tenant shall not place anything against or near glass partitions or doors or windows which may appear unsightly from outside the Premises. Tenant shall be held responsible for any damage to the glass coating within the
Premises. If Landlord objects in writing to any curtains, blinds, shades, screens or hanging plants or other similar objects attached to or used in connection with any window or door of the Premises, or placed on any windowsill, which are visible
from the exterior of the Premises. Tenant shall immediately discontinue such use. 
  
 3. Common Areas. The sidewalks, entrances, halls, corridors, elevators and stairways of the Building and the Development shall not be obstructed or used as a waiting or lounging place by Tenant and the
Tenant’s Parties. All entrance doors leading from the Premises to the hallways are to be kept closed at all times. The outside areas immediately adjoining the Premises shall be kept clear at all times by Tenant, and Tenant shall not place or
permit any obstructions, garbage, refuse, merchandise or displays in such areas. The halls, passages, exits, entrances, elevators, escalators and stairways are not open to the general public, but are open, subject to reasonable regulations, to
Tenant’s Parties. Landlord shall, in all eases, retain the right to control and prevent access thereto of all persons whose presence in the judgment of Landlord would be prejudicial to the safety of the Development or any part thereof provided
that nothing herein contained shall be construed to prevent such access to persons with whom any tenant normally deals in the ordinary course of its business, unless such persons are engaged In illegal or unlawful activities. Neither Tenant nor any
Tenant parties shall go upon the roof of the Building. 
  
 4.
Directory. The directory of the Building will be provided for the display of the name and location of tenants, and Landlord reserves the right to exclude any other names therefrom. Tenant shall be allocated its pro rata share of lines on the
Building directory board in the main lobby. 
  

 E-1 

 5. Cleanliness. Tenant shall not Exhibit carelessness or Indifference to the good order and
cleanliness of the Premises. 
  
 6. Keys. Landlord will
furnish Tenant, free of charge, with two keys to each exterior door lock in the Premises. All duplicate keys shall be purchased only from Landlord. Landlord may charge a reasonable fee for any additional keys. Tenant shall not make or have made
additional keys, acid Tenant shall not alter any lock or install a new additional lock or bolt on any door of its Premises. Tenant, upon the termination of its tenancy, shall deliver to Landlord the keys to all doors and pay Landlord for any lost
keys. 
  
 7. Security Devices. If Tenant requires
telephonic, burglar alarm or similar services, it shall first obtain and comply with Landlord’s instructions for their installation. 
  
 8. Freight Elevators. The Building service elevator shall be available for use by all tenants in the Building, subject to such reasonable
scheduling by Landlord. No equipment, materials, furniture, packages, supplies, merchandise or other property will be received in the Building or carried in the elevators except between such hours and in such elevators as may be designated by
Landlord. Tenant’s initial move-in and subsequent deliveries of bulky items, such as furniture, safes and similar items shall be made after obtaining Landlord’s written consent and shall be made during the hours of 12:00 a.m. to 5:00 am.
and 6-00 p.m. to 11:59 p.m., Monday through Friday, or at anytime on Saturday or Sunday, unless otherwise agreed in writing by Landlord. Deliveries during norms] office hours shall be limited to normal office supplies and other small items. No
deliveries shall be made which impede or interfere with other tenants or the operation of the Building. 
  
 9. Floor Load. Tenant shall not place a load upon any floor of the Premises which exceeds the load per square foot which such floor was designed to
carry and which is allowed by law. Prior to delivery of any heavy object to the Building, Tenant shall notify Landlord of such object’s specifications and contemplated location in order that Landlord may take action to prevent structural load
damage to the Building. Landlord shall have the right to prescribe the weight, size and position of all equipment, materials, furniture or other property brought into the Building. Heavy objects shall, if considered necessary by Landlord, stand on
such platforms as determined by Landlord to be necessary to properly distribute the weight, which platforms shall be provided at Tenant’s sole cost and expense. Tenant shall be responsible for all structural engineering required to determine
structural load. Business machines and mechanical equipment belonging to Tenant which cause noise or vibration that may be transmitted to the structure of the Building or to any space therein to such degree as to be objectionable to Landlord or to
any tenants in the Building, shall be placed and maintained by Tenant, at Tenant’s sole cost and expense, on vibration eliminators or other devices sufficient to eliminate noise or vibration. The persons employed to move such equipment in or
out of the Building must be acceptable to Landlord. Landlord will not be responsible for loss of or damage to any such equipment or other property from any cause, and all damage done to the Building by maintaining or moving such equipment or other
property shall be repaired at the expense of Tenant. 
  

 E-2 

 10. No Waste. Tenant shall not use any method of heating and air conditioning other than that
supplied by Landlord. Further, Tenant shall not waste electricity, water or air conditioning and agrees to cooperate fully with Landlord to assure the most effective operation of the Building’s heating and air conditioning and to comply with
any governmental energy-saving rules, laws or regulations of which Tenant has actual notice. Tenant shall keep corridor doors closed, and shall close window coverings at the end of each business day. 
  
 11. Building Identification. Landlord reserves the right, exercisable
without notice and without liability to Tenant, to change the name and address of the Building and/or any other part of the Development. 
  
 12. Building Access. Landlord reserves the right to exclude from the Building between the hours of 12:00 a.m. to 7:00 a. m. and 6:00 p.m. to 11:59
p m., Monday through Friday, and on Saturday. Sunday and holidays, any person not having a Building issue key and is not identified on the daily access list Tenant shall be responsible for all persons for whom it requests passes and shall be liable
to Landlord for all acts of such persons. Landlord may prevent Access to the Development or any part thereof in case of invasion, mob, riot, public excitement or other commotion. Landlord may exclude or expel from the Development or any part thereof
any person who, in Landlord’s judgment, is intoxicated or under the influence of liquor or drugs or is in violation of any of the rules and regulations of the Development Landlord shall not be liable for damages for any error with regard to the
admission to or exclusion from the Development or any part thereof of any person. 
  
 13. Building Security. Before Tenant and the Tenant Parties leave the Premises each day, Tenant shall (a) close and lock the doors of its Premises, (b) shut off all water faucets and other utilities, (c) draw
or lower window coverings, and (d) turn out all lights. Tenant shall be responsible for any damages or injuries sustained by other tenants or occupants of the Building or by Landlord for noncompliance with this rule. 
  
 14. Outside Services. Tenant shall not obtain for use on the Premises,
drinking water, food, beverage, towel or other similar services or accept barbering or bootblacking service upon the Premises, except at such hours and under such regulations as may be fixed by Landlord. Canvassing, soliciting and distribution of
handbills or any other written material, and peddling in the Building are prohibited, and Tenant shall cooperate to prevent such activities. 
  
 15. Lavatories. The toilet rooms, toilets, urinals, wash bowls and other apparatus shall not be used for any purpose other than that for which they
were constructed and no foreign substance of any kind whatsoever shall be thrown therein. The expense of any breakage, stoppage or damage resulting from the violation of this rule shall be borne by the Tenant who, or whose Tenant Parties, shall have
caused it. 
  
 16. Solicitation. Tenant shall not make any
room-to-room solicitation of business from other tenants in the Development or any part thereof. 
  

 E-3 

 17. Electronic Devices. Tenant shall not install any radio or television antenna, loudspeaker or
other devices on the roof or exterior walls of the Building. Tenant shall not interfere with radio or television broadcasting or reception from or in the Building or elsewhere. 
  
 18. Trash Disposal. Tenant shall store all its trash and garbage within the Premises or in other facilities provided
by Landlord. Tenant shall not place in any trash box or receptacle any material which cannot be disposed of in the ordinary and customary manner of trash and garbage disposal. All garbage and refuse disposal shall be made in accordance with
directions issued from time to time by Landlord. 
  
 19.
Prohibited Uses. The Premises shall not be used for (a) the keeping of any bicycles, motorcycles or animals of any kind, or (b) lodging, or (c) for manufacturing of any kind; nor shall the Premises be used for any illegal purpose. No cooking
or heating of food is permitted on the remises, excepting therefrom microwave ovens and equipment for brewing coffee, tea, hot chocolate and similar beverages. Such cooking and heating devices and their use should be approved by Underwriters
Laboratories in accordance with all applicable insurance regulations and federal, state, county and city laws, codes, ordinances, rules and regulations. Tenant shall not install, maintain or operate upon the Premises any vending machines without the
written consent of Landlord, which consent shall not be unreasonably withheld. 
  
 20. Prohibited Equipment. Tenant shall not use in any space or in the public halls of the Development any hand truck except those equipped with rubber tires and side guards or such other material-handling
equipment as Landlord may approve. Tenant shall not bring any other vehicles of any kind into the Building. 
  
 21. Safety Procedures. Tenant shall comply with all safety, fire protection and evacuation procedures and regulations established by Landlord or
any governmental agency. 
  
 22. Premises Security. Tenant
assumes full responsibility for protecting its space from theft, robbery and pilferage, which includes keeping doors locked and other means of entry to the Premises closed and secure. Landlord shall not in any way be responsible to Tenants or any
Tenant Party for any loss of property from the Premises or public areas or for any damage to any property thereon from any cause whatsoever. 
  
 23. Building Management. Tenant’s requirements will be amended to only upon appropriate application to the Building management office by an
authorized individual. Employees of Landlord shall not perform any work or do anything outside of their regular duties unless under special instructions from Landlord, and no employee of Landlord will admit any person (Tenant or otherwise) to any
office without specific instructions from Landlord. 
  
 24.
Waiver. Landlord may waive any one or more of these Rules and Regulations for the benefit of Tenant or any other tenant, but no such waiver by Landlord shall be construed as a waiver of such Rules and Regulations in favor of Tenant or any
other tenant, nor prevent Landlord from thereafter enforcing any such Rules and Regulations against any or all of the tenants of the Building. 
  

 E-4 

 25. Integration. These Rules and Regulations are in addition to, and shall not be construed to in
any way modify or amend, in whole or in part, the terns, covenants, agreements and conditions of the Lease. 
  
 26. Additional Regulations. Landlord reserves the right to make such other and reasonable rules and regulations as, in its judgment, may from time
to time be needed for safety and security, for care and cleanliness of the Development of any part thereof and for the preservation of good order therein. Tenant agrees to abide by all such Rules and Regulations hereinabove stated and any additional
rules and regulations which are adopted and delivered to Tenant in writing. 
  
 27. Observance of Rules. Tenant shall be responsible for the observance of all of the foregoing rules by Tenant’s employees, agents, clients, customers, invitees, licensees and guests. 
  
 28. Parking Facilities. The following rules and regulations shall
govern use of the parking facilities within the Common Areas appurtenant to the Development (such parking facilities being collectively referred to hereinafter as the “Parking Area”). 
  
 28.1 Persons using the Parking Area shall obey all signs and shall park only
in areas designated for vehicle parking within painted stall lines. Tenant’s parking spaces shall be used only for parking vehicles no longer than full-sized passenger automobiles. Tenant shall not permit any vehicle that belongs to or is
controlled by Tenant, its agents, employees, invitees, licensees and visitor, too be loaded, unloaded or parked in areas other than those designated by Landlord or its parking operator for such activities. No maintenance, washing, waxing or cleaning
of vehicles shall be permitted in the Parking Area. Unless otherwise instructed, each person using the Parking Area shall park and lock his or her own vehicle. Neither Landlord not its parking operator shall be liable for damage to any vehicle,
injury to any person or loss of any property, all of which risks are assumed by the person using the Parking Area. Parking pursuant to this Lease is intended as a license only, and no bailment is intended or created hereby. Tenant shall abide by
those rules promulgated by Landlord which provide for tandem parking. No overnight or extended term storage of any vehicles or other object shall be permitted. 
  

28.2 Persons using the Parking Area shall comply with any parking identification system established by Landlord or its parking operator. Such a system
may include the validation of visitor parking„ at the validation rate applicable to visitor parking from time to time as set by Landlord or its parking operator. Parking stickers or other identification devices supplied by Landlord shall remain
the property of landlord. Such devices shall not be transferable, and any such device in the possession of an unauthorized holder may be retained by Landlord and declared void. Upon the loss or obliteration of a parking identification device, Tenant
shall pay such reasonable replacement charge as may be established by Landlord or its parking operator. Upon the termination of parking privileges, all parking Identification devices supplied by Landlord shall be returned to Landlord. Landlord may
refuse the sale of monthly stickers or other parking identification devices to any tenant or person and/or his agents or representatives who willfully refuse to comply with these Rules and Regulations and all unposted city, state or federal
ordinances, laws, or agreements. Loss or theft of parking identification devices from automobiles must be reported to the garage manager immediately, and a lost or stolen report must be filed by the customer at that time. Landlord may 
  

 E-5 

 exclude any car from the parking facilities that does not have an identification device. Any parking identification
devices reported lost or stolen found on any unauthorized car will be confiscated and the illegal holder will be subject to prosecution. Lost or stolen devices found by the purchaser must be reported to the parking facility office immediately to
avoid confusion. 
  
 28.3 The speed limit within all parking areas
shall be five (5) miles per hour. 
  
 28.4 Landlord reserves the
right to modify, redesign or redesignate uses permitted in the Parking Area or any portion thereto to relocate parking spaces from floor to floor, from one portion of the Parking Area to another or to reasonably adjacent offsite locations, and to
allocate parking spaces between compact and standard sizes from time to time, as long as the same comply with applicable laws and ordinances. Reserved parking spaces shall be clearly and prominently marked as such by Landlord. But neither Landlord
nor its parking operator shall be liable or responsible for the failure of persons to observe such markings or to obey other rules and regulations, agreements, laws or ordinances applicable to the Parking Area. Without limiting the generality of the
foregoing, Landlord shall not be obligated to tow any violator’s vehicle, or to declare a default under or terminate the lease of any other tenant of the Building, on account of any such failure. If for any reason Landlord is unable to provide
to Tenant all or any portion of its parking spaces or Tenant is unreasonably denied access thereto during the initial term of this Lease or any renewal or extension hereof, such fact shall not be a default by Landlord or permit Tenant to terminate
this lease, either in whole or in part, but Tenant’s obligation to pay rental for any parking space which is not provided by Landlord shall be abated for so long as Tenant does not have the use of such parking space, in full settlement of all
claims that Tenant might otherwise have against Landlord by reason of Landlord’s failure or inability to provide Tenant with such parking space. 
  
 Tenant shall be responsible for the compliance with all of the foregoing rules and regulations by Tenant and Tenant Parties. Landlord may refuse to permit
any person who violates any such rules and regulations to have access to the Development or any part thereof Landlord reserves the right from time to time to modify the rules and regulations set forth herein, including, without limitation, to adopt
and modify such rules and regulations applicable to the Parking Area, as it deems necessary for the proper operation. 
  

 E-6 

 EXHIBIT F 
  
 NON-DISTURBANCE, ATTORNMENT 
 AND SUBORDINATION AGREEMENT 
  
 This Agreement is made and entered into as of the          day of
            , by and among BankBoston, N.A., as Agent for the Lenders (hereinafter called the “Lender”), having a mailing address at 100 Federal Street, Boston,
Massachusetts 02106, ELAN PHARMACEUTICALS, INC. a Delaware corporation (hereinafter called the “Tenant”), having a mailing address of 800 Gateway Boulevard, South San Francisco, CA 94080, Attn: General Counsel, and HMS Office, LP, a
Delaware limited partnership, having a mailing address c/o Hines Office Company, L.L.C., 2800 Post Oak Boulevard, 50th Floor, Houston, Texas 77056 (hereinafter called the “Landlord”). 
  
 Witnesseth: 
  
 WHEREAS, Landlord is the owner of certain real property located in South San Francisco, California, and more particularly
described in Exhibit A attached hereto and made a part hereof (said property being hereinafter called the “Property”); and 
  
 WHEREAS, Landlord and Tenant made and entered into that certain Office Building Lease, dated
            , with respect to certain premises constituting a portion of the Property therein described, known as 651 Gateway Boulevard, Suite 950 and Suite 980, South San Francisco,
California 94080 (said Lease, as amended by the amendments described above, being hereinafter called the “Lease” and said premises being hereinafter called the “Leased Premises”); and 
  
 WHEREAS, on or about the date hereof, Landlord has entered into and delivered
that certain Deed of Trust and Security Agreement/Mortgage in favor of Lender to be recorded in the              (the “Official Records”) prior to the recording of this
Agreement (said Deed of Trust and Security Agreement/Mortgage being hereinafter called the “Security Deed”), conveying the Property to secure the payment of the indebtedness described in the Security Deed; and 
  
 WHEREAS, on or about the date hereof Landlord has entered into and delivered
that certain Collateral Assignment of Leases and Rents in favor of Lender to be recorded in the Official Records prior to the recording of this Agreement (said Collateral Assignment of Leases and Rents being hereinafter called the “Assignment
of Leases”), assigning all of Landlord’s right, title and interest as lessor under the Lease to further secure the indebtedness described in the Security Deed; and 
  
 WHEREAS, the parties hereto desire to enter into this Non-Disturbance, Attornment and Subordination Agreement; 

 
 NOW, THEREFORE, for and in consideration of the mutual covenants
hereinafter set forth and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Lender, Tenant and Landlord hereby covenant and agree as follows: 
  

 F-1 

 1. ESTOPPEL 
  
 Tenant hereby certifies to Lender that (i) the Lease, as described above, is the true, correct and complete lease of the
Leased Premises, and has not been modified or amended and constitutes the entire agreement between Landlord and Tenant with respect to the Leased Premises, and (ii) as far as is known to Tenant, there are no defaults of Landlord under the Lease and
there are no existing circumstances which with the passage of time, or giving of notice, or both, would give rise to a default under the Lease and/or allow Tenant to terminate the Lease. 
  
 2. NON-DISTURBANCE 
  
 So long as no default under the Lease exists, nor any event has occurred which has continued to exist for such period of
time (after notice, if any, required by the Lease) as would entitle the lessor under the Lease to terminate the Lease or would cause, without any further action on the part of such lessor, the termination of the lease of would entitle such lessor to
dispossess the lessee thereunder, the Lease shall not be terminated, nor shall such lessee’s use, possession or enjoyment of the Leased Premises or rights under the Lease be interfered with in any foreclosure or other action or proceeding in
the nature of foreclosure instituted under or in connection with the Security Deed or in case Leader takes possession of the Property pursuant to any provisions of the Security Deed or the Assignment of Leases, unless the lessor under the Lease
would have had such right if the Security Deed or the Assignment of Leases had not been made, except that neither the person or entity acquiring the interest of the lessor under the Lease as a result of any such action or proceeding or deed in lieu
of any such action or proceeding (hereinafter called the “Purchaser”) nor Lender if Lender takes possession of or title to the Property shall be (a) liable for any act or omission of any prior lessor under the Lease; or (b) liable for the
return of any security deposit which lessee under the Lease has paid to any prior lessor under the Lease; or (c) subject to any offsets or defenses which the lessee under the Lease might have against any prior lessor under the Lease; or (d) bound by
any base rent, percentage real or any other payments which the lessee under the lease might have paid for more than the current month to any prior lessor under the lease; or (e) bound by any amendment or modification of the Lease made without
Lender’s prior written consent; or (f) bound by any consent by any lessor under the Lease to any assignment or sublease of the lessee’s interest in the Lease made without also obtaining Lender’s prior written consent; or (g)
personally liable for any default under the Lease or any covenant or obligation on its part to be performed thereunder as lessor, it being acknowledged that Tenant’s sole remedy in the event of such default shall be to proceed against
Purchaser’s or Lender’s interest in the Property. Notwithstanding anything contained herein to the contrary, Lender shall have absolutely no obligation to perform any of Landlord’s construction covenants under the Lease, provided that
if Lender shall not perform such covenants in the event of foreclosure or deed in lieu thereof and within a reasonable time following taking of possession by Lender, then Tenant shall have the right to terminate its obligations under the Lease and
to pursue any and all legal remedies it may have against Landlord and any third parties other than Lender. 
  

 F-2 

 3. ATTORNMENT 
  
 Unless the Lease is terminated in accordance with Paragraph 2, if the interests of the lessor under the Lease shall be
transferred by reason of the exercise of the power of sale contained in the Security Deed (if applicable), or by any foreclosure or other proceeding for enforcement of the Security Deed, or by deed In lieu of foreclosure or such other proceeding, or
if Lender takes possession of the Property pursuant to any provisions of the Security Deed or the Assignment of Leases, the lessee thereunder shall be bound to the Purchaser or Lender, as the case may be, under all of the terms, covenants and
conditions of the Lease for the balance of the term thereof and any extensions or renewals thereof which may be effected in accordance with any option therefor in the Lease, with the same force and effect as if the Purchaser or Lender were the
lessor under the Lease, and Tenant, as lessee under the Lease, does hereby attorn to the Purchaser and Lender if it takes possession o& the Property, as its lessor under the Lease. Such attornment shall be effective and self-operative without
the execution of any further instruments upon the succession by Purchaser to the interest of the lessor under the Lease or the taking of possession of the Property by Lender. Nevertheless, Tenant shall, from time to time, execute and deliver such
instruments evidencing such attornment as Purchaser or Lender may requires the respective rights and obligations of Purchaser, Lender and of the lessee under the Lease upon such attornment, to the extent of the then remaining balance of the term of
the Lease and any such extensions and renewals, shall be and are the same as now net forth in the Lease except as otherwise expressly provided in Paragraph 2. 
  

4. SUBORDINATION 
  
 Tenant hereby subordinates all of its right, title and interest as lessee under the Lease to the right, title and interest of Leader under the Security
Deed, and Tenant further agrees that the Lease now is and shall at all times continue to be subject and subordinate in each and every respect to the Security Deed (including, without limitation, the casualty and condemnation provisions of the Lease,
which are hereby specifically subordinated to the Security Deed) and to any and all increases, renewals, modifications, extensions, substitutions, replacements and/or consolidations of the Security Deed. 
  
 Tenant agrees that from and after the date that the Lender, its successors or
assigns, or a court appointed receiver or trustee or a bona fide third-party purchaser shall have obtained fee title to the Property pursuant to a foreclosure action or sale, deed-in-lieu of foreclosure or similar proceeding incident to the Security
Deed, any provision in the Lease providing the Tenant with an option to purchase the Property or any part thereof, or with a right of first refusal to purchase the Property or any part thereof, shall be of no further force and effect and shall
automatically terminate as of such date and, notwithstanding any provision of this Agreement or the Lease to the contrary, no such provision shall be binding upon the Leader or its successors and assigns. Without limiting the generality of the
foregoing, no such provision shall apply to a sale of the Property or any portion thereof at foreclosure or incident to a deed-in-lieu of foreclosure or similar proceeding. 
  

 F-3 

 5. ASSIGNMENT OF LEASES 
  
 Tenant hereby acknowledges that all of Landlord’s right, title and
interest as lessor under the Lease is being duly assigned to Lender pursuant to the terms of the Security Deed and the Assignment of Leases, and that pursuant to the trams thereof all rental payments under the increase shall continue to be paid to
Landlord in accordance with terms of the Lease unless and until Tenant is otherwise notified in writing by Leader. Upon receipt of any such written notice from Lender, Tenant covenants and agrees to make payment of all rental payments then due or to
become due under the Lease directly to Lender or to Lender’s agent designated in such notice and to continue to do so until otherwise notified In writing by Lender. Landlord hereby irrevocably directs and authorizes Tenant to make rental
payments directly to Lender following receipt o& such notice, and covenants and agrees that Tenant shall have the right to rely on such notice without any obligation to inquire as to whether any-default exists under the Security Deed or the
Assignment of Leases or the indebtedness secured thereby, and notwithstanding any notice or claim of Landlord to the contrary, and that Landlord shall have no right or claim against Tenant for or by reason of any rental payments made by Tenant to
Lender following receipt of such notice; provided, however, Landlord does not waive of release any rights it may have against Lender. Tenant further acknowledges and agrees: (a) that under the provisions of the Security Deed and the Assignment of
Leases, the Lease cannot be canceled or amended (nor can Landlord accept any surrender of the Lease) or terminated (except in accordance with the termination provisions in the Lease) nor can any consent be given by Landlord to the waiver or release
of Tenant from the performance or observance of any obligation under the Lease, without, in each instance, the prior written consent of Lender, and without such consent no rent may be collected or accepted by landlord more than one month in advance;
and (b) that the interest of Landlord as lessor under the Lease has been assigned to Lender for the purposes specified in the Security Deed and the Assignment of Leases, and Lender assumes no duty, liability or obligation under the Lease, except
only under the circumstances, terms and conditions specifically set forth in the Security Deed, the Assignment of Leases and this Agreement. 
  
 6. NOTICE OF DEFAULT BY LESSOR 
  
 Tenant, as lessee under the Lease, hereby covenants and agrees to give
Lender written notice properly specifying wherein the lessor under the Lease has failed to perform any of the covenants or obligations of the lessor under the Lease, simultaneously with the giving of any notice of such default to the Lessor under
the provisions of the Lease. Tenant agrees that Lender shall have the tight, but not the obligation, within thirty (30) days after receipt by Lender of such notice (or within such additional time as is reasonably required to correct any such
default) to correct or remedy, or cause to be corrected or remedied; each such default before the lessee under the Lease may take any action under the Lease by reason of such default. Such notices to Lender shall be delivered in duplicate to:

  

 F-4 

 BankBoston, N.A. 
 100 Federal Street Boston, 
 Massachusetts 02110 
 Attn: Real Estate Division 
 and 
  
 Goulston & Stows, P.C. 
 400 Atlantic Avenue Boston, 
 Massachusetts 02110 
 Attn: Michael J. Haroz, Esq. 
  
 or to such other address as the Lender shall have designated to Tenant by giving written notice to Tenant at Tenant’s address set forth on page 1 of this Agreement,
or to such other address as may be designated by written notice from Tenant to Lender. 
  
 7. NO FURTHER SUBORDINATION 
  
 Except as expressly provided to the contrary in Paragraph 4 hereof, Landlord and Tenant covenant and agree with Lender that there shall be no further subordination of the interest of lessee under the Lease to any
lender or to any other party without first obtaining the prior written consent of Lender. Any attempt to effect a further subordination of lessee’s interest under the Lease without first obtaining the prior written consent of Lender shall be
null and void. 
  
 8. AS TO
LANDLORD AND TENANT 
  
 As between Landlord and Tenant, Landlord and Tenant covenant and agree that nothing herein contained nor anything done pursuant to the provisions hereof shall be deemed or construed to modify the Lease. 
  
 9. AS TO LANDLORD AND
LENDER 
  
 As between Landlord and Lender,
Landlord and Lender covenant and agree that nothing herein contained nor anything done pursuant to the provisions hereof shall be deemed or construed to modify the Security Deed or the Assignment of Leases. 
  
 10. TITLE OF PARAGRAPHS 
  
 The titles of the paragraphs of this agreement are for convenience and
reference only, and the words contained therein shall in no way be held to explain, modify, amplify or aid in the interpretation, construction or meaning of the provisions of this agreement. 
  
 11. GOVERNING LAW 
  
 This agreement shall be governed by and construed in accordance with the
laws of the Commonwealth of Massachusetts. 
  

 F-5 

 12. PROVISIONS BINDING 
  
 The terms and provisions hereof shall be binding upon and shall inure to the
benefit of the heirs, executors, administrators, successors and permitted assigns, respectively, of Lender, Tenant and Landlord. 
  
 The reference contained to successors and assigns of Tenant is not intended to constitute and does not constitute a consent by Landlord or Lender to an assignment by
Tenant, but has reference only to those instances in which the lessor under the Lease and Lender shall have given written consent to a particular assignment by Tenant thereunder. 
  
 13. COUNTERPARTS 
  
 This agreement may be executed in any number of counterparts, each of which may be executed by less than all of the parties, each of which shall be
enforceable against the parties actually executing such counterparts, and all of which together shall constitute one instrument. 
  

 F-6 

 IN WITNESS WHEREOF, the parties have hereunto set their respective hands as of the day, month and year
first above written. 
  

	Lender:	 	BANKBOSTON, NA.
			
	 	 	By:	 	  

	 	 	Name:	 	  

	 	 	Title:	 	  

	 	 	Tenant:	 	  

  

	 	 	By:	 	  

	 	 	Name:	 	  

	 	 	Title:	 	  

		
	Landlord:	 	 HMS OFFICE, L.P.,
 a Delaware
limited partnership

			
	 	 	By:	 	 Hines Office Company, L.L.C.
 Its General
Partner

			
	 	 	By:	 	  

	 	 	Name:	 	  

	 	 	Its:	 	  

		
	Tenant:	 	 Elan Pharmaceuticals, Inc.,
 a
Delaware corporation

			
	 	 	By:	 	  

	 	 	Name:	 	  

	 	 	Title:	 	  

			
	 	 	By:	 	  

	 	 	Name:	 	  

	 	 	Title:	 	  

  

 F-7 

 FIRST AMENDMENT TO LEASE 
  
 This First Amendment to Lease (“First Amendment”) is made and entered into as of the 25th day of October, 1999 by
and between GATEWAY CENTER, LLC, a California limited liability company (“Landlord”), and ELAN PHARMACEUTICALS, INC., a Delaware corporation (“Tenant”). 
  
 R E C I T A L S: 
  
 A. HMS Office, L.P., a Delaware limited partnership (“Prior
Landlord”}, predecessor-in-interest to Landlord and Tenant catered into than certain Lease dated June 1, 1999 (the “Lease”), pertaining to the lease of approximately 9,901 rentable square feet of space (the “Existing
Premises”) known as Suites 950 and 980, and located on the ninth (9th) floor of the building located at 651 Gateway Boulevard, South San Francisco, California (the “651 Building’). 
  
 B. Tenant desires to expand the Existing Premises to include approximately
18,820 rentable square feet of space, which constitutes the entire eighth (8th) floor of the building located at 601 Gateway Boulevard, South San Francisco, California, (the “601 Building”) known as suite 800 (the “Expansion
Premises”), and to make other modifications to the Lease, and in connection therewith, Landlord and Tenant desire to amend the Lease as hereinafter provided. 
  
 A G R E E M E N T 
  
 NOW, THEREFORE, in consideration of the foregoing Recitals and the mutual
covenants contained herein, and for other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the parties hereby agree as follows: 
  
 1. Premises. 
  
 1.1 Expansion Promises. Effective as of the “Expansion Premises Commencement Date,” as that term is defined in Section 2 below.
Tenant shall lease from Landlord and Landlord shall lease to Tenant the Expansion Premises. Consequently, effective upon the Expansion Premises Commencement Date, the Existing Premise shall be increased to include the Expansion Premises. The
Existing Premises and -the Expansion Premises may hereinafter collectively be referred to as the “Premises” Landlord and Tenant hereby agree that .the addition of the total Expansion Premises to the Existing Premises shall, increase the
size of the “Premises,” as that term is defined in the Lease, to approximately 28,721 rentable square feet. 
  
 1.2 Right of First Offer. Landlord hereby grants to the Tenant named in the Summary (the “Original Tenant”) a right of fast offer
with respect to available space located on the seventh (7th) and ninth (9th) floors of the 601 Building (the “First Offer Space”). Notwithstanding the foregoing, such first offer right of Tenant shall be subordinate to all rights of which
are set forth in leases of space in the Project as of the date hereof, including any renewal, extension or expansion rights set forth in such leases, regardless of whether such renewal, extension or expansion rights are executed strictly in
accordance with their terms, or pursuant to a lease amendment or a new lease 

 (collectively, the “Superior Right Holders”) with respect to such First Offer Space. Tenant’s right of
first offer shall be on the terms and conditions set forth in this Section 1.2. 
  
 1.2.1 Procedure for Offer. Tenant shall notify Landlord prom time to time in the event Tenant is interested in leasing First Offer Space (the “Interest Notice”). For the six (6) months
immediately following Landlord’s receipt of an La crust Notice, Landlord shall promptly notify Tenant in the event First Offer Space or any portion thereof becomes available for lease to third parties, provided that no Superior Right Holder
wishes to lease such space (the “Final Offer Notice”) and such First Offer Space is not them subject to negotiation of a lease proposal or lease document with a prospective tenant. In the event no First Offer Space becomes available doting
the six (6) months following Landlord’s receipt of an Interest Notice, Tenant shall have the option to deliver another Interest Notice to Landlord. Pursuant to such First Offer Notice, Landlord shall offer to lease to Tenant the then available
First Offer Space. The First Offer Notice shall describe the spa” so offered to Tenant and shall set forth the “First Offer Ram” as that tetra is defined in Section 1.2.3 below, and the other economic terms’ upon which
Landlord is willing to lease such apace to Tenant 
  
 1.2.2
Procedure for Acceptance. If Tenant wishes to exercise Tenant’s right of first offer with respect to the space, described in the First Offer Notice, then, within fire (5) business days of delivery of the First Offer Notice to
Tenant, Tenant shall deliver notice to Landlord of Tenant’s intention to exercise its right of first-off with respect to the entire space described in the First Offer Notice on the terms contained in such notice. If Tenant “ not so notify
Landlord within the five (5) business day period, then Landlord shall be roc to lease the space described is the First Offer Notice to anyone to whom Landlord desires an any terms Landlord described. Notwithstanding anything to the contrary
contained herein, Tenant must elect to exercise its right of first offer, if at all, with respect to all of the space offered by Landlord to Tenant at any particular time, and Tenant may not elect to lease only a portion thereof. 
  
 1.2.3 First Offer Space Rent. The “Rent,” as that
term is defined in Section 4.1, below, payable by Tenant for the First Offer Space (the “First Offer Rent”) shall be equal to rent (including additional rent and considering any “base year” or “expense stop” applicable
thereto); including all escalations, at which tenants, as of the “First Offer Commencement Date,” as that term is defined in Section 1.2.5 below, are leasing nonsublease, nonencumbered, nonequity space comparable in size, location
and quality to the First Offer Space for a similar lease tags, which comparable space is located in the Project, taking into consideration the following concessions: (a) rental abatement concessions, if any, being granted such tenants in connection
with such comparable space, (b) tenant improvements or allowances provided or to be provided for such comparable space, taking into account, and deducting the value of; the existing improvements in the First Offer Space, such value to be based upon
the age, quality and layout of the improvements and the extent to which the same could be utilized by a general office user, and (c) any period of rental abatement, if any, granted to tenants in comparable transactions in connection with the design,
permitting and construction of tenant improvements in such comparable spaces. 
  

 -2- 

 1.2.4 Construction In First Offer Space. Tenant shall take the First Offer Space in its
“as is” condition, and the construction of improvements in the First Offer Space slant comply with the terms of Article 10 of the Lease. 
  
 1.2.5 Amendment to Lease. If Tenant timely exercises Tenants right to lease the First Offer Space as set forth herein, Landlord and Tenant
shall within fifteen (15) days thereafter execute a separate lease for such First Offer Space upon the terms and conditions as set forth in the First Offer Notice and this Section 1.2. Tenant shall commence payment of Rent for the First Offer
Space, and the term of the First Offer Space shall commence upon the date of delivery of the First Offer Space to Tenant (the “First Offer Commencement Date”) and terminate on the date set forth in the First Offer Notice. 
  
 1.2.6 Termination of Right of First Offer. The rights
contained in this Section 1.2 shall be personal to the Original Tenant, and may only be exercised by the Original Tenant or a permitted Assignee pursuant to Article 20 of the Lease (and not any other assignee, sublessee or other transferee of
the Original Tenant’s interest in this Lease) if the Original Tenant or such permitted Assignee occupies the entire Premises. The right of first offer granted herein shall terminate as to particular First Offer Space upon the failure by Tenant
to exercise its right of first offer with respect to such First Offer Space as offered by Landlord. Tenant shall not have the right to lease First Offer Space, as provided in this Section 1.2, if, as of the date of the attempted exercise of any
right of first offer by Tenant, or as of the scheduled date of delivery of such First Offer Space to Tenant, Tenant is in default under this Lease or Tenant has previously been in default under this Lease more than once. 
  
 2. Term. 
  
 2.1 Initial Lease Term. The terra of Tenant’s lease of the
Expansion Premises (the “Expansion Term”) shall commence on December 15, 1999 (the “Expansion Premises Commencement Date”), and shall expire, along with Tenant’s lease of the Building Premises, on December 14, 2004, unless
sooner terminated as provided in the base, as hereby amended. 
  
 2.2 Option Term. 
  
 2.2.1
Option Right. Landlord hereby grants the Original Tenant one (1) option to extend the tent Term for a period of five (5) years (the “Option Team”), which option shall be exercisable only by written notice delivered by Tenant to
Landlord as provided below, provided that, as of the date of delivery of such notice, Tenant is not in default under this Lease. Upon the proper exercise of such option to extend, and provided that, at Landlord’s option, as of the end of the
initial Lease Term, Tenant is not in default under this Lease, the Lease Term, as it applies to the Premises, shall be extended for a period of five (5) years. The rights contained in this Section 2.2 shall be personal to the Original Tenant
or a permitted Assignee pursuant to Article 20 of the Lease, and may only be exercised by the Original Tenant or such permitted assignee (and not any other assignee, sublessee or other transferee of the Original Tenant’s interest in this Lease)
if the Original Tenant occupies the entire Premises. 
  

 -3- 

 2.2.2 Option Rent. The Rent payable by Tenant during the Option Term (the “Option
Rent”) shall be equal to the rent (including additional rent and considering any “base year” or “expense stop” applicable thereto), including all escalations, at which tenants, as of the commencement of the Option Term, are
leasing nonsublease, nonencumbered space comparable in size, location and quality to the Premises for a term of five (5) years, which comparable space is located in the Building, at the building located at 651 Gateway Boulevard, or within a five (5)
mile radius of the Building, taking into consideration the following concessions: (a) rental abatement concessions, if any, being wanted such tenants in connection with such comparable spaces and (b) tenant improvements or allowances provided or to
be provided for such comparable space, taking into account, and deducting the value of the existing improvements in the Premises, such value to be based upon the age, quality and layout of the improvements and the extent to which the same could be
utilized by Tenant based upon the fact that the precise tenant improvements existing in the Premises am specifically suitable to Tenant. 
  
 2.2.3 Exercise of Options. The option contained in this Section 2.2 shall be exercised by Tenant. If at all, and only in the following
manner (i) Tenant shall deliver written notice to Landlord not more than eight (8) months nor less than seven (7) months prior to the expiration of the initial Lease Term, stating that Tenant is interested is exercising its option; (ii) Landlord,
after receipt of Tenant’s notice, shall deliver notice (the “Option Rent Notice”) to Tenant not less than five (5) months prior to the expiration of due initial Lease Term, setting forth the Option Rent; and (iii) if Tenant wishes to
exercise such option, Tenant shall, on or before the earlier of (A) the date occurring four (4) months prior to the expiration of the initial Lease Terms, and (B) the date occurring thirty (30) days after Tenant’s receipt of the Option Rent
Notice, exercise the option by delivering written notice thereof to Landlord and upon. and concurrent with, such exercise, Tenant may, at its option, object to the Option Rent contained in the option Rent Notice, is which case the parties shall
follow the procedure, and the Option Rent shall be determined, as set forth in Section 2.2.4 below. 
  
 2.2.4 Determination of Option Rent. In the event Tenant timely objects to the Option Rent, Landlord and Tenant shall attempt to agree upon
the Option Rent using their best good faith efforts. If Landlord and Tenant fail to reach agreement within ten (10) business days following Tenant’s objection to the Option Rent (the “Outside Agreement Date”), then each party shall
make a separate determination of the Option Rent within five (5) business days after the Outside Agreement Date, and such determinations shall be submitted to arbitration in accordance with Sections 2.2.4.1 through 2.2.4.7 below. 
  
 2.2.4.1 Landlord and Tenant shall each appoint one (1) arbitrator who shall
be a real estate broker who shall have been active over the five (5) )ear period ending on the date of such appointment in the leasing of commercial high-rise properties in South San Francisco, California. The determination of the arbitrators shall
be limited solely to the issue of whether Landlord’s or Tenant’s submitted Option Rent is the closest to the actual Option Rent as determined by the arbitrators, taking into account the requirements of Section 22.2 of this Lease. Each such
arbitrator shall be appointed within fifteen (15) days after the Outside Agreement Date. 
  

 -4- 

 2.2.4.2 The two (2) arbitrators so appointed shall within ten (10) days of the date of the appointment
of the last appointed arbitrator agree upon and appoint a third arbitrator who shall be qualified under the same criteria set forth hereinabove for qualification of the initial two (2) arbitrators. 
  
 2.2.4.3 The three (3) arbitrators shall within thirty (30) days of the
appointment of the third arbitrator reach a decision as to whether the parties shall use Landlord’s or Tenant’s submitted Option Rent and shall notify Landlord and Tenant thereof. 
  
 2.2.4.4 The decision of the majority of the three (3) arbitrators shall be
binding upon Landlord and Tenant. 
  
 2.2.4.5 If either Landlord
or Tenant fails to appoint an arbitrator within fifteen (15) days after the outside Agreement Date, then the arbitrator appointed by one of them shall reach a decision notify landlord and Tenant hereof, and such arbitrator’s decision shall be
binding upon Landlord and Tenant. 
  
 2.2.4.6 If the two (2)
arbitrators foil to agree upon and appoint a third arbitrator, or if both parties fail to appoint an arbitrator, then the appointment of the third arbitrator or any arbitrator shall be dismissed and the matter to be decided shall be forthwith
submitted to arbitration under the provisions of the American Arbitration Association, but subject to the instruction set forth in this Section 2.24. 
  
 2.2.4.7 The cost of the arbitration shall be paid by Landlord and Tenant equally. 
  
 3. Rent. 
  
 3.1 Base Rent for Expansion Premises. Tenant shall continue to pay Base Rent and Additional Rent for the Existing Premises is accordance
with the terms of the Lease. Notwithstanding any contrary provision of the Lease, as hereby amended, commencing on the Expansion Premises Commencement Date and continuing throughout the Expansion Term, Tenant shall pay to Landlord annual Base Rent
in connection with the Expansion Premises in the following amounts: 
  

	 Months of Lease Term

	 	 Annual Rental Rate

	 	 Monthly Base Rate

	 	 Monthly Base
 Rent per Square Foot

	  1-24	 	$474,264.00	 	$39,522.00	 	$2.10
	25-48	 	$496,848.00	 	$41,404.00	 	$2.20
	49-60	 	$519,432.00	 	$43,286.00	 	$2.30

  

 -5- 

 Upon Tenant’s execution and delivery of this First Amendment, Tenant shall pay to Landlord the
monthly installment of Base Rent for the Expansion Premises payable for the first full month of the Expansion Term. 
  
 3.2 Tenant’s Share of Operating Expenses. Tenant shall continue to pay to Landlord Tenant’s Share of Operating Expenses in
connection with Tenant’s lease of the Existing Premises in accordance with the terms of the Lease. Notwithstanding anything in the Lease, as hereby amended, to the contrary, commencing as of the Expansion Premises Commencement Date, Tenant
shall pay Tenant’s Share of Operating Expenses in connection with Tenant’s lease of the Expansion Premises in accordance with the terms of Article 4 of the Lease, as amended; provided, however, that effective as of the Expansion
Premises Commencement Date, the Lease, as amended, as it pertains to the Expansion Premises, shall be converted into a “Triple Net” lease. Tenant recognizes and acknowledges, without limiting the generality of any other terms or provisions
of the Lease, as amended, that it is the intent of the parties hereto that any and all expenses incurred in connection with the Premises or the 601 Building, or the operations thereon, including any end all taxes, assessments, general or special
license fees, insurance premiums, public utility bills, and costs of repair, maintenance and operation of the Premises and the 601 Building and all structures, improvements or permanent fixtures comprised therein, together with the appurtenances
thereto, shall be paid by Tenant in addition to the Base Rent specified in the Lease, as amended. All references in the Lease to an Operating Expense Base shall be of no force and effect with respect to the Expansion Premises. 
  
 4. Signage. Subject to the terms of this Section 4, and
provided Tenant occupies an entire floor of the Building, Tenant shall be entitled, at its sole cost and expense, to install the following signage: 
  
 (i) Exclusive building top signage for the 601 Building, as follows: two (2) signs identifying Tenant located at the top of the 601 Building, one (1)
facing Highway 101 and one (1) facing Gateway Boulevard, such signs to be subject to all applicable laws and regulations, and Landlord’s reasonable approval. Tenant shall pay to Landlord the sum of Two Thousand Five Hundred and No/100 Dollars
$2,500.00 per month as a fee for such signage during the first year of the Expansion Term (the “Signage Fee”), and on the first anniversary of the Expansion Term and each anniversary thereafter (the “CPI Adjustment Date”), the
Signage Fee shall be increased to equal the product of (i) the Signage Fee, as the same may have bees previously increased pursuant to this Section 4, multiplied by (ii) a fraction, the numerator of which is the “Adjustment Month Index,”
as flat term is defined in Section 4(A)(1) below, occurring prior to such CPI Adjustment Date and the denominator of which is either (I) for the Initial CPI Adjustment Date, the “Base Mouth Index,” as that terra is defined in Section
4(A)(2) below, or (11) for all subsequent CPI Adjustment Dates, the Adjustment Month Index used as the numerator for the previous CPI Adjustment Date; 
  
 A) Base Pent Adjustment Definitions. As used in this Lease, the following terms shall have the meanings hereinafter set forth: 
  

 -6- 

 1) “Adjustment Month Index” shall mean the “Index,” as that term is defined in
Section 4(A)(3), below, for that month which is the same calendar month as the Base Month Index immediately preceding each succeeding CPI Adjustment Date. 
  
 2) “Base Month Index” shall mean the Index for the third month immediately preceding the month in which the Initial Adjustment Date occurs. By
way of example only, if the Expansion Premises Commencement Date were to occur on December 1, 1999, then the Initial Adjustment Date would occur on December 1, 2000, the Base Month Index would be the Index for September, 2000, and the Adjustment
Month Index for each succeeding CPI Adjustment Date would be the Index for that month of September immediately preceding such CPI Adjustment Date. 
  
 3) “Index” shall mean the Consumer Price Index for all Urban Consumers for the San Francisco area (base year 1982 1984 100), published by the
United States Department of Labor, Bureau of Labor Statistics. If the base of the Index changes from the 1982-84 base (100), the Index shall, thereafter, be adjusted to the 1982-84 base 100 before the computation indicated above is made. If the
Index cannot be converted to the 1982-84 base or if the Index is otherwise revised, the adjustment under this section shall be made with the use of such conversion factor, formula or table for converting the Index as may be published by the Bureau
of Labor Statistics. If the Index is at any time no longer published, a comparable index generally accepted and employed by the real estate profession, as determined by Landlord in Landlord’s sole but reasonable discretion, shall be used.

  
 (ii) Building standard interior signage, consistent with
Landlord’s standard signage criteria. 
  
 5.
Parking. Effective as of the Expansion Premises Commencement Date and continuing throughout the Expansion Term, and notwithstanding any contrary provision in the Lease, Tenant shall have the right, free of charge to unreserved parking
passes at the 601 Building parking facility at a ratio of three and three tenths (3.3) passes per 1,000 rentable square feet of the Expansion Premises, of which up to three (3) may be for the use of a reserved parking space in a location reasonably
designated by Tenant, subject to availability. Except as set forth in this Section 5, Tenant shall lease the parking passes for the Expansion Premises in accordance with the provisions of Section 26.5 of the Lease. 
  
 6. Assignment and Subletting. The provisions of Article 20 of
the Lease shall apply to Tenant’s right to assign or sublease the Expansion Premises; provided, however, that notwithstanding the provisions of Section 20.3, any rent or other consideration pertaining to the Expansion Premises realized by
Tenant, in excess of the Rent payable pursuant to the Lease, as amended (the “Transfer Premium”), shall be allocated as follows: fifty percent (50%) to Tenant sad fifty percent (50%) to Landlord. Such Transfer premium shall be calculated
pursuant to the terms of Section 20.3 of the Lease, as amended. 
  

 -7- 

 7. Brokers. Landlord and Tenant hereby warrant to each other that they have had no dealings
with any real estate broker or agent in connection with the negotiation of this Fifth Amendment, and that they know of no real estate broker or agent other than CRESA Partners (the “Broker”) who is entitled to a commission in connection
with this Fifth Amendment. Each party agrees to indemnify sand defend the other party against and hold the other party harmless from any and all claims, demands, losses, liabilities, lawsuits, judgments, and costs and expenses (including, without
limitation, reasonable attorney fees) with respect to any leasing commission or equivalent compensation alleged to be owing on account of the indemnifying party’s dealings with any real estate broker or agent outer than the Broker. The terms of
this Section shall survive the expiration or earlier termination of this Fifth Amendment. 
  
 8. Improvement Allowance. Tenant shall be entitled to a onetime allowance for the purchase and installation of improvements which are permanently affixed to the Premises (the “Improvements”) in
the amount of up to $112,920.00 (i.e., $6.00 per rentable square foot of the Premises multiplied by 18,820 rentable square feet) (the “Improvement Allowance”). The connection and installation of the Improvements shall be made in accordance
with the terms of Section 10.2 of the Lease, and the Improvements shall be deemed Alterations for all purposes hereunder. The Improvement Allowance shall be disbursed by Landlord pursuant to Landlord’s disbursement process. All costs related to
the construction of the improvements in excess of the Improvement Allowance (as the same may be reduced by the application of the same as a credit against Base Rent in accordance with the foregoing sentence) shall be paid by Tenant in accordance
with Section 102 of the Lease. In the event that Improvement Allowance is not fully utilized by Tenant within one (1) year following the Expansions Premises Commencement Date (either to pay for costs related to the construction of the Improvements
or as a credit against Base Rent), then such unused amounts shall revert to Landlord and Tenant snail have no further rights with respect thereto. Tenant shall have the right to select its own architect and contractor(s) for the interior
improvements, subject to Landlord’s prior approval, which shall not be unreasonably withheld. Landlord shall not charge a fee to supervise Tenant’s construction work within the Premises. 
  
 9. Defined Terms. Except as explicitly set forth in this First
Amendment, all defined terms herein shall have their respective meanings as set forth in the Lease and the terms and provisions of the Lease are unmodified and shall remain in full force and effect. 
  
 10. No Further Modification. Except as specifically set forth
in this First Amendment, all of the terms and provisions of the Lease shall remain unmodified and in full force and effect. In the event of any conflict between the terms and conditions of the Lease and the terms and conditions of this First
Amendment, the terms and conditions of this First Amendment shall prevail. 
  

 -8- 

 The terms and conditions of this First Amendment, the terms and conditions of this First Amendment shall
prevail. 
  
 IN WITNESS WHEREOF, Landlord and Tenant have caused
this First Amendment to be executed on the day and date first above written. 
  

	 “LANDLORD”
  
 GATEWAY CENTER, LLC
 a California limited company

		
	By:	 	 /s/    BOB
PESTER      

	Its:	 	 
		
	By:	 	 Bob Pester

	Its:	 	Senior Vice President and Regional Manager

  

	 “TENANT”
  
 ELAN PHARMACEUTICALS, INC.
 a
Delaware corporation

		
	By:	 	 /s/    [Signature Illegible]

	Its:	 	 
		
	By:	 	

	Its:	 	 

  

 EXHIBIT B 
  
 PREMISES 
  
  

 B-1 

 [GRAPHIC] 

 EXHIBIT C 
  
 PERSONAL PROPERTY INVENTORY 
  
 13 desks (approximately 30” or 36” by 66” or 72”) 
 14 credenzas (approximately 20” by 66” or 72”) 
 14 workstations (including panels, work surfaces, task
lights, shelves and tack boards) 
  

 C-1 

 EXHIBIT D 
  
 PAINT AND CARPET SPECIFICATIONS 
  

	 Carpet
	  	 
			
	 	  	 Manufacturer:
	  	Designweave
	 	  	 Type:
	  	Dense Cut Pile Plush; 32 ox.; Static Control Nylon
	 	  	 Name:
	  	Tempest II
	 	  	 Color:
	  	Tenant selection from Standard Colors
	 	  	 Install:
	  	Over Pad
	
	 Wall Finishes

			
	 	  	 Manufacturer:
	  	To be Selected from the following:
	 	  	 Dunn-Edwards

	 	  	 Fuller Obrien Benjamin Moore

	 	  	 Sinclair Paint

	 	  	 Type:
	  	1 Prime Coat; 2 Finish Coats
	 	  	 Finish:
	  	Eggshell; smooth
	 	  	 Color:
	  	As Specified

  

 D-1 

 EXHIBIT E 
  
 PBX SWITCHING SYSTEM 
  

The telephone system consists of a NEC 20001VS PBX. This system has the circuit cards (see attachment) to handle 36 digital phones (not included), 20
analog lines for modems and faxes, 8 incoming copper Ground Start Trunks, and 2 TI lines. This system will require Sublessee to obtain either copper or T1’s from a local phone company. Also, the system will require Sublessee to install NEC
phones. Maintenance and operation of the system will be the responsibility of the Sublessee. Sublessee must obtain a maintenance agreement for the system to ensure its life over the period of occupancy. 
  

 E-1Prepared by R.R. Donnelley Financial -- Sublease Agreement dated March 21, 2003

 EXHIBIT 10.6B 
 SUBLEASE 
  
 651 GATEWAY
BOULEVARD 
 (SUITE 980) 
  
 SOUTH SAN FRANCISCO, CALIFORNIA 
  
 ELAN PHARMACEUTICALS, INC. 
 a Delaware
corporation 
  
 as Sublessor 
  
 and 
  
 TERCICA MEDICA, INC. 
 a Delaware corporation 
  
 as
Sublessee 
  

 BASIC SUBLEASE INFORMATION 
  
 DEFINED TERMS 
  

	 Building:
	  	 651 Gateway Boulevard
 South San
Francisco, California 94080

		
	 Effective Date:
	  	March 21, 2003
		
	 Commencement Date:
	  	The date following the Effective Date which is the later of (i) the date upon Sublessor has tendered possession of the Premises to Sublessee, or (ii) the date upon which Sublessor
has obtained Master Landlord’s consent to this Sublease, subject to the terms and conditions of Section 17.3 hereof.
		
	 Rent Commencement Date:
	  	The later of (i) April 1, 2003 or (ii) the Commencement Date.
		
	 Master Landlord:
	  	Gateway Center, LLC, a California limited liability company, successor in interest to HMS Office, L.P., a Delaware limited partnership
		
	 Master Landlord’s Address for Notice:
	  	 Boston Properties
 Four Embarcadero
Center, Lobby Level, Suite One
 San Francisco, CA 94111-5994
 Phone: 415 772-0700
 Fax: 415 982-1780
 Attn: Christine
Charles, Lease Administrator

		
	 Master Lease:
	  	That certain Office Building Lease by and between HMS Office, L.P., and Sublessor, dated as of June 1, 1999 (the “Original Lease”), as amended by that certain First
Amendment to Lease between Gateway Center, LLC and Sublessor, dated as of October 25, 1999 (the “Amendment”), true and complete copies of which are attached hereto and incorporated herein as Exhibit A.
		
	 Master Premises:
	  	Suite 950 (“Suite 950”) and Suite 980 of the building located at 651 Gateway Boulevard, South San Francisco, California and the entire eighth (8th) floor of the building located at 601 Gateway Boulevard, South San Francisco, California
		
	 Premises:
	  	Improved real property consisting of Suite 980 on the 9th floor of the building located at 651 Gateway Boulevard, South San Francisco, California, as more particularly described in the Master Lease, consisting of a portion of the Master Premises, containing

  

 i 

	 	  	approximately 2,411 rentable square feet as depicted on Exhibit B attached hereto and incorporated herein, and a non-exclusive right to utilize all of Sublessor’s
leasehold interest in the Common Areas (as defined in Section 1 of the Master Lease).
		
	 Monthly Base Rent:
	  	For the period beginning on the Rent Commencement Date and ending one calendar month thereafter, the Monthly Base Rent shall be $0.00. Thereafter, Monthly Base Rent shall be
$2,772.65 per month.
		
	 Storage Space Rent:
	  	$134.40 per month (reflecting a rate of $1.20 per square foot for 112 square feet of Storage Space), subject to periodic adjustment at any time without notice to reflect any
increase by Landlord
		
	 Security Deposit:
	  	$2,907.05
		
	 Sublessee:
	  	Tercica Medica, Inc., a Delaware corporation
		
	 Sublessee’s Address for Notice:
	  	 651 Gateway Boulevard, 9th floor
 South
San Francisco, CA 94080
 Attn: Howard Moore

		
	 Sublessee’s Proportionate Share:
	  	 Twenty four (24%) of Additional Rent for the Existing Premises (as defined in Section 4.2 of the Original Lease and excluding any
Operating Expenses in connection with the Expansion Premises) (See Section 3.2 below) and Sublessee Taxes (as defined in Section 3.2 of this Sublease).

		
	 Sublessor:
	  	Elan Pharmaceuticals, Inc., a Delaware corporation
		
	 Sublessor’s Address for Rent and Notice:
	  	 7475 Lusk Boulevard
 San Diego, CA
92121
 Attn: Rick Smith

		
	 	  	With a copy to:
		
	 	  	 800 Gateway Boulevard
 South San
Francisco, CA 94080
 Attn: Vice President, Legal Affairs

		
	 Term:
	  	The term (“Term”) of this Sublease shall begin on the Commencement Date and expire on December 14, 2004. Notwithstanding the foregoing, the Term shall cease upon, and
shall not refer to any period

  

 ii 

	 	  	of time after, termination of the Master Lease (whether pursuant to the terms of the Master Lease, by operation of law, or otherwise).
		
	 Permitted Uses:
	  	The Uses set forth in Section 7 of the Master Lease.
		
	 Brokers:
	  	CB Richard Ellis, Inc. for Sublessor
		
	 	  	BT Commercial for Sublessee
		
	 Exhibits:
	  	 Exhibit A – Master Lease
 Exhibit B – Premises Depiction
 Exhibit C – Personal Property Inventory
 Exhibit D – Storage Agreement
 Exhibit E – Form
General Warranty Bill of Sale

	

  
  

 iii 

 TABLE OF CONTENTS 
  

	 	  	Page

	 ARTICLE 1 - PREMISES
	  	1
	 1.1    Demise of Premises
	  	1
	 1.2    Condition of Premises
	  	2
	 1.2.1    Physical Condition
	  	2
	 1.2.2    No Representations
	  	2
	 1.3    Validation of Master Lease
	  	2
		
	 ARTICLE 2 - TERM
	  	2
		
	 ARTICLE 3 - SUBLESSEE’S PAYMENT OBLIGATIONS
	  	3
	 3.1    Monthly Base Rent
	  	3
	 3.2    Additional Rent
	  	3
	 3.3    Security Deposit
	  	4
		
	 ARTICLE 4 - INTENTIONALLY LEFT BLANK
	  	4
		
	 ARTICLE 5 - USE
	  	4
		
	 ARTICLE 6 - RIGHTS AND DUTIES OF SUBLESSEE
	  	4
	 6.1    Sublease Subject o Master Lease
	  	4
	 6.2    Exclusions
	  	5
	 6.3    Time for Notice
	  	6
	 6.4    Sublessor’s Obligations
	  	6
	 6.5    Use of Building Common Areas
	  	6
	 6.6    Entry by Sublessor
	  	6
		
	 ARTICLE 7 - LEASE AND PURCHASE OF PERSONAL PROPERTY
	  	6
		
	 ARTICLE 8 - INDEMNIFICATION
	  	7
		
	 ARTICLE 9 - INSURANCE
	  	7
		
	 ARTICLE 10 - DEFAULTS AND REMEDIES
	  	7
		
	 ARTICLE 11 - NOTICES
	  	7
		
	 ARTICLE 12 - ASSIGNMENT AND SUBLETTING
	  	8
		
	 ARTICLE 13 - REPAIRS AND MAINTENANCE
	  	8

  

 iv 

	 ARTICLE 14 - DAMAGE AND DESTRUCTION
	  	8
	 14.1    Termination of Master Lease
	  	8
	 14.2    Continuation of Sublease
	  	8
		
	 ARTICLE 15 - SURRENDER OF PREMISES
	  	9
		
	 ARTICLE 16 - INTENTIONALLY LEFT BLANK
	  	9
		
	 ARTICLE 17 - MISCELLANEOUS
	  	9
	 17.1    Entire Agreement
	  	9
	 17.2    Captions
	  	9
	 17.3    Master Landlord’s Consent
	  	10
	 17.4    Authority
	  	10
	 17.5    Attorneys’ Fees
	  	10
	 17.6    Broker
	  	10
	 17.7    Counterparts
	  	10
	 17.8    Severability
	  	10
	 17.9    Governing Law
	  	11
	 17.10    Negotiated Transaction
	  	11

  
  

 v 

 SUBLEASE AGREEMENT 
  
 THIS SUBLEASE AGREEMENT (“Sublease”) is entered as of the Effective Date by and between Sublessor and
Sublessee. 
  
 THE PARTIES ENTER this Sublease on the basis
of the following facts, understandings and intentions: 
  
 A.    Master Landlord is the current Landlord of the Premises. Sublessor is presently the Tenant of the Premises pursuant to the Master Lease. A copy of the Master Lease with all amendments, exhibits and addenda thereto,
is attached hereto as Exhibit A and, except as set forth in this Sublease, incorporated herein by this reference. 
  
 B.    Sublessor and Sublessee are parties to a certain sublease effective as of June 24, 2002 whereby Sublessor subleases Suite 950 to
Sublessee (the “950 Lease”) and, pursuant to Article 16 of the 950 Lease, Sublessee has a right of first offer for the Premises (the “Right of First Offer”). 
  
 C.    Pursuant to a letter dated February 25, 2003 Sublessee has chosen to exercise its Right of First
Offer. 
  
 D.    Sublessor desires to sublease
the Premises to Sublessee and Sublessee desires to sublease the Premises from Sublessor on all of the terms, covenants and conditions set forth herein. 
  
 E.    All of the terms and definitions of the Basic Sublease Information of this Sublease are incorporated herein by this reference.
Unless otherwise defined herein or the context otherwise requires, all capitalized terms shall have the meanings given them in the Master Lease. 
  
 NOW, THEREFORE, IN CONSIDERATION of the above facts, the mutual covenants and promises of the parties, and for other good and valuable
consideration the receipt and sufficiency of which is hereby acknowledged, the parties hereto agree as follows: 
  
 ARTICLE 1 - PREMISES 
  
 1.1    Demise of Premises.    Sublessor hereby subleases to Sublessee and Sublessee hereby subleases from Sublessor the Premises, for the Term and upon all of the
terms and conditions herein set forth. The Premises shall be used by Sublessee for those uses specifically set forth in the Basic Sublease Information, subject to the terms and conditions of the Master Lease, including Section 7 of the Master Lease.
In addition, Sublessor shall lease to Sublessee, and Sublessee shall lease from Sublessor, the storage space relating to the Storage Agreement attached as Exhibit D hereto (the “Storage Space”), the personal property set forth on
Exhibit C hereto (the “Exhibit C Property”) and any and all permanent improvements in or on the Premises (all of the foregoing collectively, the “Improvements”) constructed and/or owned by Master Landlord and/or Sublessor
upon all of the terms, covenants and conditions herein contained. As used herein, “Premises” shall include the Premises, the Storage Space and the Improvements. The Premises represents twenty-four (24%) of 
  

 1 

 
the total space in the Existing Premises, which shall be Sublessee’s “Proportionate Share” of Additional Rent (as defined in the Basic
Sublease Information). It is understood that Sublessee shall accept the Premises on the Commencement Date in “as is” condition. 
  
 1.2    Condition of Premises. 
  

1.2.1    Physical Condition.    Sublessor will deliver the Premises to Sublessee in its current
“as-is” condition as of the Effective Date. As of the Effective Date, Sublessee acknowledges that Sublessee has conducted Sublessee’s own investigation of the Premises and the physical condition thereof, which in Sublessee’s
judgment affect or influence Sublessee’s use of the Premises and Sublessee’s willingness to enter this Sublease and that, except as otherwise expressly set forth herein, neither Sublessor nor any of its employees or agents have made or
shall have any liability for any representations or warranties, express or implied, with respect to the condition of the Premises. Except as otherwise expressly set forth herein, by occupying the Premises on the Commencement Date, Sublessee shall be
deemed to have acknowledged that it accepts the Premises in their current condition. Sublessee agrees on the last day of the Sublease Term to surrender the Premises unto Sublessor in accordance with Article 15 of this Sublease. 
  
 1.2.2    No
Representations.    Sublessee and Sublessor recognize and agree that Sublessor would not sublease the Premises to Sublessee and Sublessee would not sublease the Premises from Sublessor except on an “as is” basis
and acknowledges that neither Sublessee nor Sublessor has made any representations of any kind, express or implied, in connection with the Improvements or physical conditions on, or bearing on, the Premises, including without limitation the
suitability of the Premises for Sublessee’s purposes. Sublessee further recognizes and agrees that neither Sublessor nor Master Landlord shall be required to perform any work of construction, alteration or maintenance of or to the Premises
except as expressly set forth herein. Notwithstanding the foregoing, Sublessee shall not be required to construct or pay the cost of complying with any covenants, conditions, restrictions, encumbrances, rules, regulations, statutes, ordinances, laws
or building codes requiring construction or improvements to any alterations, improvements or additions to the Premises that were made by Sublessor and are properly capitalized under general accounting principles, unless such compliance is
necessitated solely because of Sublessee’s particular use of the Premises. 
  
 1.3    Validation of Master Lease.    Sublessor hereby warrants that the Master Lease attached hereto as Exhibit A is complete and in full force and effect,
and that Sublessor is not in material default thereunder beyond expiration of any applicable cure or notice period, that, to the knowledge of Sublessor, (i) no other party to the Master Lease is in breach or default thereof, (ii) the area which is
the subject of the Sublease has not been previously assigned or subleased by Sublessor, and (iii) no other party has a legal right to occupy such area. 
  
 ARTICLE 2 - TERM 
  
 The term of this Sublease shall be for the Term set forth in the Basic Sublease Information provided that upon full execution of this Sublease by
Sublessor and Sublessee, and on or before the Commencement Date Sublessee provides Sublessor with (i) the certificates evidencing the insurance 
  

 2 

 
required by Article 9 of this Sublease, (ii) the first month’s Base Rent and Storage Space Rent and (iii) the Security Deposit. 
  
 ARTICLE 3 - SUBLESSEE’S PAYMENT OBLIGATIONS 
  
 3.1    Monthly Base
Rent.    The Monthly Base Rent and the Storage Space Rent shall be payable in advance in equal monthly installments in accordance with the Monthly Base Rent and the Storage Space Rent set forth in the Basic Sublease
Information, commencing with the Rent Commencement Date. Upon the execution of this Sublease by Sublessor and Sublessee, Sublessee shall deposit with Sublessor prepaid Rent in an amount equal to Two Thousand-Seven Hundred Seventy Two Dollars and
Sixty Five Cents ($2,772.65) for the first month’s Monthly Base Rent due following once the one calendar month Monthly Base Rent abatement period set forth in the Basic Sublease Information and One Hundred and Thirty Four Dollars and Forty
Cents ($134.40) for the first month’s Storage Space Rent (“Prepaid Rent”) (for avoidance of doubt, the parties hereby agree and acknowledge that there is not a one month abatement period for the Storage Space Rent). Sublessee shall
thereafter pay to Sublessor the Monthly Base Rent and the Storage Space Rent in advance, on or before the first day of each month, beginning on the first day of the calendar month succeeding the Rent Commencement Date. Monthly Base Rent, Storage
Space Rent and any additional rent due hereunder shall be payable to Sublessor, without further notice or demand and without deduction or offset, in lawful money of the United States of America at the address specified in the Basic Sublease
Information or at such other address as Sublessor may from time to time designate in writing. If the Term shall end on a day other than the last day of a calendar month, then Rent for the last month of the Term shall be prorated on a per diem basis,
with respect to the portions of the last fractional calendar month included in the Term. 
  
 3.2    Additional Rent.    In addition to Monthly Base Rent and Storage Space Rent, Sublessee shall be responsible for (a) Sublessee’s Proportionate Share of
the Additional Rent (as set forth in the Basic Sublease Information), it being the intent of the parties hereto that Sublessee shall owe no Operating Expenses (as defined in the Master Lease) to Sublessor applicable to calendar year 2003, (b)
Sublessee Taxes (as defined below) and (c) all other additional rent which may be imposed, at any time, on Sublessor with respect to the Premises pursuant to the Master Lease; provided that Sublessee shall not be responsible for any penalties,
interest or other costs incurred by Sublessor under the Master Lease that are caused by (i) Sublessee’s failure to pay rent to Master Landlord in a timely manner in accordance with the Master Lease, unless such failure is cause by
Sublessee’s default or failure to make timely payments to Sublessor in accordance with this Sublease, or (ii) a breach of the Master Lease or Sublease by, or the acts or negligence of Sublessor or its agents, representatives, sublessees,
employees or invitees (except to the extent such breach, negligence or acts were caused by Sublessee or its agents, representatives, sublessees, employees or invitees). As used herein, “Sublease Rent” shall include Base Rent, Storage Space
Rent, Sublessee’s Proportionate Share of Additional Rent, Sublessee Taxes and all other amounts payable by Sublessee to Sublessor hereunder. Sublessee shall be responsible for the Sublessee Rent for each and every month of the Sublease Term
commencing with the Rent Commencement Date. Sublessee shall pay its Proportionate Share of Additional Rent and Sublessee Taxes no later than thirty (30) days following Sublessee’s receipt of written demand therefor. 
  

 3 

 “Sublessee Taxes” shall consist of all taxes, fees or charges levied or assessed against or
attributable to any personal property or trade fixtures in the Premises or by reason of leasehold improvements. If any such taxes, fees or charges are included in Sublessor’s or Master Landlord’s taxes, Sublessor may pay them regardless of
the validity (under proper protest, if requested by Sublessee and at Sublessee’s sole cost and expense), and Sublessee will pay Sublessor the amount of Sublessor’s or Master Landlord’s taxes, as applicable, attributable to Sublessee,
as determined in good faith by Sublessor. 
  
 3.3    Security Deposit.    Upon the execution of this Sublease by Sublessor and Sublessee, Sublessee shall pay to Sublessor the Security Deposit set forth on the Basic Sublease
Information. Sublessor may (but shall not be required to) use the Security Deposit or any portion thereof to cure any defaults on the part of Sublessee (beyond any applicable cure period) or to reasonably compensate Sublessor for any damage
Sublessor incurs as a result of Sublessee’s failure to perform any of its covenants or obligations hereunder (provided Sublessee has been given any required notice and opportunity to cure such failure as set forth under the terms of this
Sublease), it being understood that any use of the Security Deposit shall not constitute a bar or defense to any of Sublessor’s remedies under this Sublease, at law or in equity. In such event, and upon written notice from Sublessor to
Sublessee specifying the amount of the Security Deposit so utilized by Sublessor and the particular purpose for which such amount was applied, Sublessee shall immediately deposit with Sublessor an amount sufficient to return the Security Deposit to
the amount specified in the Basic Sublease Information. Upon termination or earlier expiration of this Sublease, the Security Deposit shall be returned to Sublessee within the designated period under applicable law, reduced by those amounts that may
be required by Sublessor to remedy defaults on the part of Sublessee in the payment of Sublessee Rent, to repair damage to the Premises and to clean the Premises to a broom-clean condition. Sublessor shall hold the Security Deposit for the foregoing
purposes; provided, however, that Sublessor shall have no obligation to segregate the Security Deposit from its general funds or to pay interest thereon. 
  
 ARTICLE 4 - INTENTIONALLY LEFT BLANK 
  
  
 ARTICLE 5 - USE 
  
 The Premises are to be used for the Permitted Uses, and for no other purpose
or business without the prior written consent of Sublessor. In no event shall the Premises be used for a purpose or use prohibited by the Master Lease or the Storage Agreement. 
  
 ARTICLE 6 - RIGHTS AND DUTIES OF SUBLESSEE 
  
 6.1    Sublease Subject o Master Lease.    It is expressly understood,
acknowledged and agreed by Sublessee that this Sublease shall incorporate by reference the terms, conditions and covenants of the Master Lease and the Storage Agreement, except as excluded in Section 6.2 below, modified as appropriate in the
circumstances so as to make such Sections applicable only to the subleasing hereunder by Sublessor of the Premises during the Term of this Sublease. Sublessee shall be subject to, bound by and comply with all of said Sections of the Master Lease and
the Storage 
  

 4 

 
Agreement with respect to the Premises accruing during the Term of this Sublease, and shall satisfy all such terms and conditions of the Master Lease and the
Storage Agreement for the benefit of both Sublessor and Master Landlord, it being understood and agreed that wherever in the Master Lease or in the Storage Agreement the word “Tenant” appears, for the purposes of this Sublease, the word
“Sublessee” shall be substituted (subject to the limitations set forth in this Sublease), wherever in the Master Lease or the Storage Agreement the word “Landlord” appears, for the purposes of this Sublease, the words
“Master Landlord” (and, as applicable hereunder, “Sublessor”) shall be substituted; and wherever in the Master Lease the word “Premises” appears or wherever in the Storage Agreement the word “Storage Area”
appears, for the purposes of this Sublease, the words “Master Premises” shall be substituted; and that upon the breach of any of said terms, conditions or covenants of the Master Lease or Storage Agreement by Sublessee or upon the failure
of Sublessee to pay the Sublease Rent or comply with any of the provisions of this Sublease, Sublessor may exercise any and all rights and remedies granted to Master Landlord by the Master Lease or the Storage Agreement, as the case may be.
Sublessee expressly acknowledges, notwithstanding anything to the contrary in this Sublease, that Sublessee’s duty to indemnify, defend and hold Sublessor harmless from and against any and all fines, suits, losses, costs, expenses, liabilities,
claims, demands, actions, damages and judgments pursuant to this Sublease, and as more specifically set forth in Section 14 of the Master Lease and in Section 4 of the Storage Agreement, shall include Sublessor’s duty to indemnify, defend,
protect and hold Master Landlord harmless from and against any and all fines, suits, losses, costs, expenses, liabilities, claims, demands, actions, damages and judgments. 
  
 It is further understood and agreed that Sublessor has no duty or obligation to Sublessee under the aforesaid Sections of
the Master Lease or the Storage Agreement other than to maintain the Master Lease and the Storage Agreement in full force and effect during the term of this Sublease and to pay the difference between the Sublease Rent and the rent due and payable
under the Master Lease and the Storage Agreement; provided, however, that Sublessor shall not be liable to Sublessee for any earlier termination of the Master Lease or the Storage Agreement which is not due to the fault of Sublessor. In the event of
any conflict between this Sublease and the Master Lease or the Storage Agreement, the Sublease shall control, as between Sublessor and Sublessee. Whenever the provisions of the Master Lease or the Storage Agreement incorporated as provisions of this
Sublease require the written consent of Landlord or notice to Landlord, said provisions shall be construed to require the written consent and/or notice of both Master Landlord and Sublessor. Sublessee hereby acknowledges that it has read and is
familiar with all the terms of the Master Lease and the Storage Agreement, and agrees that this Sublease is subordinate and subject to the Master Lease and the Storage Agreement and that any termination thereof without the fault of Sublessor shall
likewise terminate this Sublease. 
  
 6.2    Exclusions.    The terms and provisions of the following Sections of the Original Lease are not incorporated into this Sublease: The first and second paragraphs of Section 2,
Sections 3 through 5, 8, 9(a), 10.1(b), 14, 24.1, the second sentence of Section 26.7 and the third paragraph of Section 10.2. The terms and provisions of the following Sections of the Amendment are not incorporated into this Sublease: Sections 1.2,
2.2, and 3 through 8. The terms and provisions of the following Sections of the Storage Agreement are not incorporated into this Sublease: 2 and 7. 
  

 5 

 6.3    Time for Notice.    The time limits provided
for in the provisions of the Master Lease or the Storage Agreement for the giving of notice, making of demands, performance of any act, condition or covenant, or the exercise of any right, remedy or option, are amended for the purposes of this
Sublease by lengthening or shortening the same in each instance by five (5) days, as appropriate, so that notices may be given, demands made, or any act, condition or covenant performed, or any right, remedy or option hereunder exercised, by
Sublessor or Sublessee, as the case may be, within the time limit relating thereto contained in the Master Lease or the Storage Agreement. If the Master Lease or the Storage Agreement allows only five (5) days or less for Sublessor to perform any
act, or to undertake to perform such act, or to correct any failure relating to the Premises or this Sublease, then Sublessee shall nevertheless be allowed three (3) days to perform such act, undertake such act and/or correct such failure.

  
 6.4    Sublessor’s
Obligations.    It shall be the obligation of Master Landlord (i) to provide or cause to be provided all services to be provided by Landlord under the terms of the Master Lease and the Storage Agreement and (ii) to
satisfy all obligations and covenants of Master Landlord made in the Master Lease and the Storage Agreement. Sublessee acknowledges that Sublessor shall be under no obligation to provide any such services or satisfy any such obligations or
covenants; provided, however, Sublessor, upon written notice by Sublessee, shall attempt to enforce all obligations of Master Landlord under the Master Lease and the Storage Agreement, provided that Sublessee reimburses Sublessor for all reasonable
costs and expenses incurred in connection therewith (except as otherwise set forth in Section 1.2.2 hereof). Sublessor shall not amend, terminate or waive any provisions under the Master Lease or the Storage Agreement or make any elections, exercise
any right or remedy or give any consent or approval under the Master Lease or the Storage Agreement that could result in a substantial interference with Sublessee’s use of the Premises or materially increase Sublessee’s obligations or
decrease Sublessee’s rights under this Sublease without, in each instance, Sublessee’s prior written consent. 
  
 6.5    Use of Building Common Areas.    Sublessee shall comply with all reasonable and
non-discriminatory rules and regulations established by Sublessor with respect to use of the Common Areas, and shall insure compliance therewith by all of Sublessee’s employees, contractors and invitees. 
  
 6.6    Entry by
Sublessor.    Upon forty-eight (48) hours advance verbal or written notice (except in case of emergency where no such notice shall be required), Sublessor shall have the right to enter upon the Premises for purposes of
maintenance and repair, and to ensure compliance by Sublessee with its obligations pursuant to this Sublease. Sublessee shall provide Sublessor with two keys (including card keys, if applicable) to all doors of the Premises in order to facilitate
such entry. 
  
 ARTICLE 7 - LEASE AND PURCHASE OF PERSONAL
PROPERTY 
  
 During the Term, Sublessee shall have the
right, at no additional cost and expense to Sublessee, other than payment of the Sublessee Rent, to use the Exhibit C Property. On the last day of the Term of this Sublease, Sublessee shall purchase the Exhibit C Property, free and clear of all
liens and encumbrances, by delivering $1.00 to Sublessor pursuant to a General Warranty Bill of Sale in the form of Exhibit E hereto. Upon purchase, the Exhibit C Property shall be owned by 
  

 6 

 
Sublessee and Sublessee shall be responsible for removing the Exhibit C Property from the Premises in accordance with Article 15 hereof. 
  
 ARTICLE 8 - INDEMNIFICATION 
  
 Except to the extent resulting from the acts, negligence or breach of this
Sublease, the Master Lease or the Storage Agreement by Sublessor (where such breach is not caused by Sublessee), Sublessee covenants to indemnify, defend, protect and hold Sublessor, its agents, officers, employees, and contractors harmless from and
against (i) any and all claims, causes of action, obligations, liabilities, costs and expenses (including reasonable attorneys’ fees and costs) to the extent arising out of or in connection with Sublessee’s use or occupancy of the Premises
or the Common Areas before or after the commencement of the Term of this Sublease, and (ii) the breach of this Sublease (or, to the extent incorporated herein, the Master Lease or the Storage Agreement) by Sublessee, its employees, agents,
contractors or invitees. Sublessee’s obligations under this Article 8 shall survive the termination or earlier expiration of this Sublease. 
  
 ARTICLE 9 - INSURANCE 
  
 Sublessee covenants to obtain and maintain the insurance policies required to be maintained by Sublessor under Section 15 of the Master Lease naming
Sublessor as an additional insured; to provide Sublessor with certificates evidencing such insurance; and not to merit cancellation or termination of such required insurance policies without giving at least fifteen (15) days prior written notice to
Sublessor and Master Landlord. Sublessee shall deliver to Sublessor, from time to time and upon Sublessor’s or Master Landlord’s reasonable written request, certificates of insurance indicating that the required policies of insurance are
in full force and effect throughout the entire term of this Sublease. All insurance policies required to be carried by Sublessor pursuant to the Master Lease and the Storage Agreement shall be carried by Sublessee, covering Sublessee’s
liability, and all such policies shall be written in accordance with the requirements for such insurance set forth in Section 15 of the Master Lease. 
  
 ARTICLE 10 - DEFAULTS AND REMEDIES 
  
 In the event of a default by Sublessee, Sublessor shall have all of the rights and remedies against Sublessee as are set forth in Section 19 of the Master
Lease as though Sublessor were the landlord named therein and Sublessee was the tenant named therein. A default under this Sublease shall be deemed to be a default under the 950 Lease and shall provide the parties with all of the rights and remedies
thereunder. 
  
 ARTICLE 11 - NOTICES 
  
 All notices or correspondence provided for herein shall be in writing and
shall be sent by certified mail, postage prepaid, return receipt requested, or by a nationally-recognized overnight delivery company which provides a receipt evidencing delivery, in which event they shall be deemed received on the date of delivery
as evidenced by the receipt. The Master Landlord’s, Sublessor’s and Sublessee’s addresses for written notices required to be given hereunder shall be the addresses set 
  

 7 

 
forth in the Basic Sublease Information, or at such other place designated by advance written notice delivered in accordance with the foregoing. 

 
 ARTICLE 12 - ASSIGNMENT AND SUBLETTING 
  
 Sublessee shall not sell, assign, encumber, sublet, hypothecate or otherwise
transfer by operation of law or otherwise this Sublease or the Sublessor’s interest in and to the Premises except in accordance with Section 20 of the Master Lease as modified by this Sublease. 
  
 ARTICLE 13 - REPAIRS AND MAINTENANCE 
  
 Except to the extent constituting an obligation of the Master Landlord under
the Master Lease, Sublessee shall, at Sublessee’s sole expense, keep the Premises in good order and sanitary condition, and repair any damage thereto caused by Sublessee or Sublessee’s agents, employees, contractors or invitees. In
performing its obligations under this Article 13, Sublessee shall notify Sublessor and of any repairs that could affect the Systems serving the Building (exclusive of the Premises) and shall use contractors approved by Master Landlord, in its
reasonable discretion. Sublessee acknowledges that, except as otherwise expressly provided herein, Sublessor is under no duty to make repairs or improvements to the Premises, and Sublessee hereby waives any right it may have at law or in equity to
enforce the same. Notwithstanding the foregoing, to the extent Master Landlord is obligated under the Master Lease to make any maintenance or repairs in or to the Premises, Sublessor, upon written notice by Sublessee, shall attempt to enforce such
obligations of Master Landlord, provided that (except as provided in Section 1.2.3 hereof) Sublessee reimburses Sublessor for all reasonable costs and expenses incurred in connection therewith. Notwithstanding the foregoing, if such maintenance or
repairs affect the use and enjoyment of the Common Area, such costs and expenses of enforcement shall be paid by Sublessor and Sublessee in proportion to their relative interests in the Master Premises. 
  
 ARTICLE 14 - DAMAGE AND DESTRUCTION 
  
 14.1    Termination of Master
Lease.    If the Premises is damaged or destroyed and Master Landlord, Sublessor or Sublessee validly exercises any option to terminate the Master Lease or this Sublease as specifically provided for in the Master Lease or
this Sublease (or in the Master Lease as incorporated herein by reference), if any, this Sublease shall terminate as of the date of the termination of the Sublease by either party hereto or the date of the termination of the Master Lease.

  
 14.2    Continuation of
Sublease.    If the Master Lease is not terminated following any damage or destruction as provided above, this Sublease shall remain in full force and effect. Sublessee shall be obligated to fulfill any repair obligations
of Sublessor with respect to the Premises; provided, however, that (i) Sublessor shall use commercially reasonable means to enforce any obligation of Master Landlord to rebuild the Premises in accordance with the Master Lease; (ii) Sublessor shall
make available to Sublessee any insurance proceeds Sublessor receives as a result of damage or destruction of the Premises; and (iii) Sublessee shall be entitled to abatement of Sublessee Rent on a proportionate basis (based on the degree to which
Sublessee’s use of the Premises is impaired as compared to the impairment of Sublessor’s use of the Master Premises) to 
  

 8 

 
the extent that Sublessor’s Rent is abated under the Master Lease. In the event that the damage cannot reasonably be repaired by the date that is 90
days prior to the expiration of the Term of this Sublease, then either party may terminate this Sublease by written notice to the other party. Notwithstanding anything to the contrary contained herein, if such damage or destruction occurs and the
Premises can not be, or is in fact not, restored so that such damage or destruction does not unreasonably interfere with Sublessee’s normal business operations within 180 days following the date of such damage or destruction, Sublessee shall
have the right to terminate this Sublease immediately upon deliver of written notice to Sublessor. 
  
 ARTICLE 15 - SURRENDER OF PREMISES 
  
 Sublessee shall peaceably surrender the Premises to Sublessor upon expiration or earlier termination of this Sublease, broom-clean and in as good a
condition as when Sublessee took possession and Sublessee shall remove Sublessee’s personal property and any or all Alterations made by Sublessee (provided that Master Landlord or Sublessor so notified Sublessee in accordance with Section 10.2
of the Master Lease), upon the expiration or earlier termination of this Sublease and promptly repair all damage to the Premises caused by such removal. Unless Master Landlord or Sublessor requires their removal, all Alterations made to the Premises
by Sublessee shall remain upon and be surrendered with the Premises at the expiration or earlier termination of this Sublease. 
  
 If Sublessee abandons the Premises, any of Sublessee’s personal property left on the Premises shall be deemed to be abandoned, and, at
Sublessor’s option, title shall pass to Sublessor under this Sublease as by a bill of sale. If Sublessee abandons the Premises and Sublessor elects to remove all or any part of Sublessee’s personal property, the reasonable cost of removal,
including repairing any damage to the Premises or Building caused by such removal, shall be paid by Sublessee. The provisions of this Article 15 shall survive the expiration or earlier termination of this Sublease. 
  
 ARTICLE 16 - INTENTIONALLY LEFT BLANK 
  
  
 ARTICLE 17 - MISCELLANEOUS 
  
 17.1    Entire Agreement.    This Sublease, the 950 Lease and the applicable portions of the Master Lease and the Storage Agreement contained by reference herein, contain all of the
covenants, conditions and agreements between the parties concerning the Premises, and shall supersede any and all prior correspondence, agreements and understandings concerning the Premises, both oral and written. No addition or modification of any
term or provision of this Sublease shall be effective unless set forth in writing and signed by both Sublessor and Sublessee. 
  
 17.2    Captions.    All captions and headings in this Sublease are for the purposes of reference
and convenience and shall not limit or expand the provisions of this Sublease. 
  

 9 

 17.3    Master Landlord’s Consent.    This
Sublease is conditioned upon Master Landlord’s written approval of this Sublease prior to the Commencement Date. If Master Landlord refuses to consent to this Sublease, then this Sublease shall be deemed void and of no effect, in which event
the parties shall be discharged from all obligations hereunder and Sublessor shall return the Prepaid Rent, if previously delivered to Sublessor, to Sublessee. If Master Landlord does not provide consent to this Sublease on or before April 15, 2003
in a form of consent acceptable to Sublessee and Sublessor, each in its sole discretion, or if Sublessor is unable to tender possession of the Premises to Sublessee on or before April 15, 2003 (through no fault of Sublessor), then either party may
by written notice delivered to the other party no later than five (5) days following such date, have the right to terminate this Sublease, in which event the parties shall be discharged from all obligations hereunder and Sublessor shall return the
Prepaid Rent, if previously delivered to Sublessor, to Sublessee. 
  
 17.4    Authority.    Each person executing this Sublease on behalf of a party hereto represents and warrants that he or she is authorized and empowered to do so and to thereby bind the
party on whose behalf he or she is signing. 
  
 17.5    Attorneys’ Fees.    In the event either party shall bring any action or proceeding for damages or for an alleged breach of any provision of this Sublease to recover rents,
or to enforce, protect or establish any right or remedy hereunder, the prevailing party shall be entitled to recover reasonable attorneys’ fees and court costs as part of such action or proceeding. 
  
 17.6    Broker.    Sublessor shall be responsible for payment of any and all finder’s fees or commissions to CD Richard Ellis, Inc. and BT Commercial (“Brokers”) in
connection with this Sublease pursuant to a separate agreement. Each party warrants and represents that it has had no dealings with any real estate broker, agent or finder other than Brokers in connection with the negotiation of this Sublease, and
that it knows of no other real estate broker or agent who is entitled to any commission or finder’s fee in connection with the Premises or this Sublease. Each party shall indemnify and hold the other harmless from and against any and all
claims, demands, losses, liabilities, lawsuits, judgments, costs and expenses (including without limitation, attorneys’ fees and costs) arising from any claim for a leasing commission or equivalent compensation alleged to be owing on account of
the indemnifying party’s dealings with any real estate broker or agent in connection with the Premises or this Sublease. 
  
 17.7    Counterparts.    This Sublease may be executed in any number of counterparts, each of which
shall be deemed to be an original and all of which taken together shall comprise but a single instrument. 
  
 17.8    Severability.    If any provisions of this Sublease or the application of any provision of
this Sublease to any person or circumstance is, to any extent, held to be invalid or unenforceable, the remainder of this Sublease or the application of that provision to persons or circumstances other than those as to which it is held invalid or
unenforceable, will not be affected, and each provision of this Sublease will be valid and be enforced to the fullest extent permitted by law. 
  

 10 

 17.9    Governing Law.    This Sublease will be
governed by and in all respects construed in accordance with the laws of the State of California, without giving effect to any choice of law rule that would cause the application of the laws of any jurisdiction other than the State of California.

  
 17.10    Negotiated
Transaction.    The parties mutually acknowledge that this Sublease has been negotiated at arm’s length. The provisions of this Sublease shall be deemed to have been drafted by all of the parties and this Sublease
shall not be interpreted or construed against any party solely by virtue of the fact that such party or its counsel was responsible for its preparation. 
  
 [Remainder of This Page Intentionally Left Blank] 
  

 11 

 IN WITNESS WHEREOF, the parties hereto have executed one (1) or more copies of this Sublease,
effective as of the Effective Date. 
  
  

	 “SUBLESSOR”
  
  
 ELAN PHARMACEUTICALS, INC.
 a Delaware corporation

		
	By:	 	 /s/    DAVID HURLEY

		
	Name:	 	 David Hurley

		
	Its:	 	 CFO

  
  

	 “SUBLESSEE”
  
  
 TERCICA MEDICA, INC.
 a Delaware corporation

		
	By:	 	 /s/    HOWARD MOORE

		
	Name:	 	 Howard S. Moore

		
	Its:	 	 Executive Vice President

  
  
  
 EXHIBIT A 
  
 MASTER LEASE 

  
  
  
  
  
  
  
 OFFICE BUILDING
LEASE 
  
 by and between 
  
 HMS OFFICE, L.P., 
 a Delaware Limited Partnership 
  
 and 
  
 ELAN PHARMACEUTICALS, INC., 
 a
Delaware corporation 
  

 LEASE SUMMARY 
  

	 Date:
	  	June 1, 1999
		
	 Tenant
	  	Elan Pharmaceuticals, Inc., a Delaware corporation
		
	 Address:
	  	 800 Gateway Boulevard
 South San
Francisco, California 94080
 Attn: General Counsel
  
 with copy to:
  
 800 Gateway Boulevard
 South San Francisco, California 94080
 Attn: Chief Financial Officer

		
	 Landlord:
	  	HMS Office, L.P.
		
	 Address:
	  	 c/o Hines Interests Limited Partnership
 651 Gateway Boulevard, Suite 1140
 South San Francisco, California 94080

		
	 Premises:
	  	Suite 950 and Suite 980
		
	 Building:
	  	 651 Gateway Boulevard
 South San
Francisco, California 94080

		
	 Approximate Rentable Area of Premises:
	  	Nine Thousand Nine Hundred One (9,901) square feet comprised of (i) Seven Thousand Four Hundred Ninety (7,490) square feet located in Suite 950 (“Suite 950 Space”), and
(ii) Two Thousand Four Hundred Eleven (2,411) square feet located in Suite 980 (the “Suite 980 Space”)
		
	 Approximate Rentable Area of Building:
	  	Two Hundred Ninety Thousand Four Hundred Forty-Seven (290,447) square feet
		
	 Estimated Commencement Date:
	  	July 1, 1999
		
	 Term:
	  	2 Lease Years
		
	 Base Rent:
	  	Twenty-Eight Thousand Two Hundred Seventeen and 85/100ths Dollars ($28,217.85) per month (based upon $2.85 per rentable square foot per month)
		
	 Operating Expense Base:
	  	$8.07 per square foot of Rentable Area per year

	 Security Deposit:
	  	Twenty-Eight Thousand Two Hundred Seventeen and 85/100ths Dollars ($28,217.85)
		
	 Use:
	  	General office use
		
	 Parking Spaces:
	  	Thirty-One (31)
		
	 Guarantor:
	  	Not applicable
		
	 Exhibits:
	  	A, B, C, D, E and F
		
	 Broker:
	  	Marc Pearson of Catalyst CRESA Real Estate Group, as Tenant’s representative

  

 TABLE OF CONTENTS 
  

	 Page No.

			
	 	  	1.    Definitions	  	1
			
	 	  	2.    Demise	  	5
			
	 	  	3.    Acceptance Of Premises	  	7
			
	 	  	4.    Rent	  	7
			
	 4.1
	  	Base Rent	  	8
			
	 4.2
	  	Additional Rent	  	8
			
	 	  	5.    Security Deposit	  	8
			
	 	  	6.    Services Provided By Landlord	  	9
			
	 	  	7.    Use; Hazardous Substances	  	10
			
	 7.1
	  	Use of Premises	  	10
			
	 7.2
	  	Hazardous Substances	  	10
			
	 	  	8.    Brokers	  	11
			
	 	  	9.    Tenant’s Taxes	  	11
			
	 	  	10.    Alterations, Repairs And Maintenance	  	12
			
	 10.1
	  	Repairs and Maintenance	  	12
			
	 10.2
	  	Alterations	  	13
			
	 	  	11.    Liens	  	14
			
	 	  	12.    Entry	  	15
			
	 	  	13.    Landlord’s Liability	  	15
			
	 	  	14.    Indemnification And Exculpation	  	15
			
	 	  	15.    Insurance	  	16
			
	 	  	16.    No Subrogation	  	17
			
	 	  	17.    Damage Or Destruction	  	17
			
	 17.1
	  	Cancellation of Lease; Restoration of Building.	  	17
			
	 17.2
	  	Casualty Loss During Last Year of Lease	  	18
			
	 17.3
	  	Abatement of Rent	  	18

  

 i 

 TABLE OF CONTENTS 
 (continued) 
  

	 Page No.

			
	 	  	18.    Condemnation	  	18
			
	 	  	19.    Defaults And Remedies	  	19
			
	 19.1
	  	Events of Default	  	19
			
	 19.2
	  	Remedies	  	20
			
	 19.3
	  	Continuing Liability	  	21
			
	 19.4
	  	Remedies Cumulative	  	21
			
	 19.5
	  	No Waiver	  	22
			
	 	  	20.    Assignment Or Sublease	  	22
			
	 20.1
	  	Notification	  	22
			
	 20.2
	  	Landlord Approval	  	22
			
	 20.3
	  	Allocation of Excess Rent	  	23
			
	 20.4
	  	Fair Market Rent	  	23
			
	 20.5
	  	No Release front Liability	  	23
			
	 20.6
	  	Compliance with Laws	  	23
			
	 20.7
	  	Reimbursement of Costs	  	23
			
	 20.8
	  	Negotiation with Assignee	  	24
			
	 20.9
	  	Change of Control; Affiliates.	  	24
			
	 20.10
	  	Conveyance by Landlord	  	24
			
	 	  	21.    Subordination	  	25
			
	 	  	22.    Estoppel Certificate	  	25
			
	 	  	23.    Intentionally Deleted	  	26
			
	 	  	24.    Surrender Of Premises	  	26
			
	 24.1
	  	Leasehold Improvements and Fixtures	  	26
			
	 24.2
	  	Holding Over	  	26
			
	 	  	25.    Professional Fees	  	27
			
	 	  	26.    General Provisions	  	27

  

 TABLE OF CONTENTS 
 (continued) 
  

	 Page No.

			
	 26.1
	  	Mortgage Protection	  	27
			
	 26.2
	  	Successors and Assigns	  	27
			
	 26.3
	  	Waiver	  	27
			
	 26.4
	  	Identification of Tenant	  	28
			
	 26.5
	  	Parking	  	28
			
	 26.6
	  	Interpretation of Lease	  	28
			
	 26.7
	  	Limitation on Liability	  	29
			
	 26.8
	  	Traffic Impact	  	29
			
	 26.9
	  	Financial Statements	  	29
			
	 26.10
	  	Quiet Enjoyment	  	29
			
	 26.11
	  	Payment and Notice	  	29
			
	 26.12
	  	Late Charge	  	30
			
	 26.13
	  	Rules and Regulations	  	30
			
	 26.14
	  	Rights Reserved by Landlord	  	30
			
	 26.15
	  	Related Padres	  	31
			
	 26.16
	  	Landlord’s Costs	  	31
			
	 26.17
	  	Invoices	  	31
			
	 26.18
	  	Force Majeure; Time of Essence	  	31
			
	 26.19
	  	Negotiated Transaction	  	32
			
	 26.20
	  	Non-Disturbance; Attornment and Subordination Agreement	  	32
			
	 26.21
	  	Nondiscrimination	  	32
			
	 26.22
	  	Corporate Authority	  	32
			
	 26.23
	  	Notice Pursuant to California Health d Safety Code Section 25359.7	  	32
			
	 26.24
	  	Entire Agreement; Amendments.	  	33

  
  

 THE GATEWAY 
  
 OFFICE BUILDING LEASE

  
 This Lease is made and entered into as of the date
specified in the Lease Summary attached hereto and incorporated herein by this reference, by and between HMS OFFICE, L.P., a Delaware limited partnership (“Landlord”), and the Tenant identified in the Lease Summary. 
  
 In consideration of the mutual covenants and agreements contained in this
Lease, the parties agree as follows: 
  
 1.    DEFINITIONS 
  
 Certain terms used in this Lease and the Exhibits hereto shall have the meaning set forth below for each such term. Certain other terms shall have the meaning set forth elsewhere in this Lease and the Exhibits hereto. 
  
 “Base Rent” means the basic rent payable by Tenant per month
during the Term in the amounts shown on the Lease Summary and in the manner provided in Section 4. 
  
 “Building” means the building described in the Lease Summary and any future expansions of that building. 
  
 “business days” means Monday through Friday, except
holidays; “holidays” means those holidays specified by the laws of the United States or State of California, and all holidays to which maintenance employees of the Building are entitled from time to time under their union contract or other
agreement. 
  
 “Commencement Date” means the
earlier of (i) the date that Landlord delivers possession of the Premises to Tenant, or (ii) the date set forth on the Lease Summary as the Estimated Commencement Date. 
  
 “Common Areas” means the Building’s common entrances, lobbies, restrooms, elevators, stairways and
accessways, loading docks, ramps, drives, platforms and passageways and serviceways thereto, and the common pipes, conduits, wires and appurtenant equipment serving the Premises, together with trash areas, parking areas, roadways, sidewalks,
walkways, parkways, driveways and landscaped areas and similar areas and facilities appurtenant to the Building. 
  
 “Development” means that real property (including without limitation, the Building, the Common Areas and the Premises) situated in the
City of South San Francisco, County of San Mateo, State of California, being more particularly described on Exhibit A-1 attached hereto as such real property may be modified from time to time by Landlord. 
  
 “Fair Market Rent” means the rate being charged in the
Building for comparable space, taking into consideration: location in the Building, tenant improvements or allowances provided or 
  

 1 

 
to be provided, rental abatements, lease takeovers/ assumptions, moving expenses and other forms of rental concessions, proposed term of lease, extent of
service provided or to be provided, the ownership of the comparable space, the time the particular rate under consideration became or is to become effective and any other relevant terms or conditions. 
  
 “Guarantor” means any guarantor of any of Tenant’s
obligations under this Lease. 
  
 “Landlord
Parties” means the employees, agents, contractors, officers, directors, partners, licensees, invitees, and guests of Landlord, Landlord’s affiliates, Landlord’s managing agent and Mortgagee. 
  
 “Lease Years” means successive periods of twelve (12) full
calendar months, beginning on the Commencement Date. If the Commencement Date is not the first day of a month, then the first Lease Year also includes the partial month in which the Commencement Date occurs. 
  
 “Mortgage” means any mortgage or deed of trust, blanket or
otherwise, covering any part of the Development. “Mortgagee” means the holder of a Mortgage. 
  
 “Operating Expenses” means all expenses and costs (but not specific costs that are separately billed to and paid by specific tenants) of
every kind and nature that Landlord shall pay or incur or become obligated to pay or incur (including, without limitation, costs incurred by managers and agents that are reimbursed by Landlord) because of or in connection with the management,
maintenance, preservation, ownership and operation of the Development and its supporting facilities directly servicing the Development (as allocated to the Development in accordance with generally accepted accounting principles, consistently
applied) including, but not limited to, the following: 
  
 (a)    Wages, salaries and reimbursable expenses and benefits of all on-site and off-site personnel engaged in the operation, maintenance and security of the Development and the direct costs of training such employees,
limiting such charges only to amounts directly allocable to services rendered by the employees and personnel for the benefit of the Development. 
  
 (b)    Costs of the property management office and office operation. 
  
 (c)    All supplies, materials and rental equipment used in the operation and maintenance of the
Development, including, without limitation, temporary lobby displays and events, the cost of erecting, maintaining and dismantling art work and similar decorative displays commensurate with operation of a first-class office building. 
  
 (d)    Utilities, including, without limitation, water,
power, gas, sewer, waste disposal, communication and cable T.V. facilities, heating, cooling, lighting and ventilation of the Development. 
  
 (e)    All maintenance, janitorial and service agreements for the Development and the equipment therein, including, but not limited
to, alarm service, window cleaning, elevator 

  

 2 

 
maintenance, and maintenance and repair of sidewalks, landscaping, Building exterior and service areas. 
  
 (f)    A management cost recovery equal to three percent
(3%) of all revenues (excluding such management cost recovery) derived from the Development. 
  
 (g)    Legal and accounting services for the Development, including, but not limited to, the costs of audits by certified public accountants of Operating Expenses records and reasonable legal fees
and costs incurred by Landlord in any legal proceeding against any other specific tenant where such other tenant is responsible (either pursuant to its lease or at law) for payment of such fees and costs but is unwilling or is unable to pay such
fees and costs after reasonable efforts have been made by Landlord to pursue reimbursement from such tenant; provided, however, that legal expense shall not include the cost of (i) negotiating lease terms for prospective tenants, (ii) negotiating
termination or extension of leases with existing tenants, (iii) proceedings against any other specific tenant relating solely to the collection of rent or other sums due to Landlord from such tenant, or (iv) legal costs incurred in connection with
development and/or construction of the Development. 
  
 (h)    All insurance premiums and costs, including, but not limited to, the premiums and cost of fire, casualty, liability, rental abatement and earthquake insurance applicable to the Development and Landlord’s
personal property used in connection therewith (and all amounts paid as a result of loss sustained that would be covered by such policies but for commercially reasonable “deductible” or self-insurance provisions); provided, however, that
Landlord may, but shall not be obligated to, carry earthquake insurance (if Landlord elects to carry earthquake insurance, Tenant shall not be responsible for premium costs for such earthquake insurance in excess of premiums customarily charged for
earthquake insurance to landlords of similar buildings in the Northern San Mateo County area). 
  
 (i)    Repairs, replacements and general maintenance (except for repairs and replacements (i) paid for from the proceeds of insurance,
(ii) paid for directly by Tenant, other tenants or any third party, or (iii) for the benefit solely of tenants of the Development other than Tenant to the extent that Tenant could not obtain similar services from Landlord without an obligation to
reimburse Landlord for the entire cost thereof under the provisions of this Lease). 
  
 (j)     All real and personal property taxes and general and special assessments imposed by any governmental authority or agency on the Building and a pro rata portion of any taxes and general and
special assessments levied on the Development; any assessments levied in lieu of, or in substitution for, such taxes; and any other costs, fees or charges levied or assessed by, or at the direction of, any federal, state, or local government
authority in connection with the ownership, use or occupancy of the Development, whether or not now in effect or foreseeable (excluding penalties, fines and interest charges imposed as a result of Landlord’s failure to pay timely the same;
provided that, Tenant has timely paid its proportionate share of Operating Expenses hereunder); and any reasonable expenses, including the reasonable cost of attorneys or experts, incurred by Landlord in seeking reduction by the taxing authority of
the above-referenced taxes, less any tax refunds obtained on account of such taxes previously paid and for which Tenant has paid Tenant’s Share thereof as a result of an application for review thereof; provided, however, that such taxes shall
not 

  

 3 

 
include: (i) taxes paid by Tenant pursuant to Section 9 or by other tenants in the Development pursuant to similar provisions in their leases; or (ii)
franchise, transfer, inheritance, or capital stock taxes or income taxes measured by the net income of Landlord from all sources, unless, due to a change in the method of taxation, any of such taxes is levied or assessed against Landlord as a
substitute for, or as an addition to, in whole or in part, any other tax that would otherwise constitute the taxes described in the preceding provisions of this clause (j). 
  
 (k)    Amortization (together with reasonable financing charges) of capital improvements made to the
Development that (i) are or will be required to comply with applicable law, ordinance, rule or regulation, enacted or enforced after the Commencement Date; (ii) are replacements of items which Landlord is obligated to maintain; or (iii) are intended
to improve the operating efficiency of the Development, provided, however, that in the case of improvements made solely for efficiency purposes, the amount chargeable as an Operating Expense in any year shall not exceed Landlord’s reasonable
determination of the efficiency achieved either in direct cost savings, avoidance of cost increases or a combination of both. As used in this definition of Operating Expenses, “amortization” shall mean allocation of the cost equally to
each year of useful life of the items being amortized or a shorter period equal to the number of years required to recover the cost of said item of capital improvement out of the savings in operating efficiency derived therefrom. Notwithstanding the
foregoing, however, Landlord may treat as expenses (chargeable in the year incurred) and not as capital costs items that are less than two percent (2%) of estimated Operating Expenses for the year in question. 
  
 Notwithstanding any other provision herein to the contrary, if the
Development is not fully occupied during any year of the Term, an adjustment shall be made in computing Operating Expenses for such year so that Operating Expenses shall be computed as though the Development had been fully occupied during such year;
provided, however, that in no event shall Landlord collect in total, from Tenant and all other tenants of the Development, an amount greater than one hundred percent (100%) of the actual Operating Expenses during any year of the Term. 
  
 “Operating Expense Base” means the dollar amount per square
foot of the Rentable Area as set forth on the Lease Summary. 
  
 “Prime Rate” means the rate of interest from time to time announced by Bank of America National Trust and Savings Association as its reference rate or, if no such rate is being announced, such reasonable substitute as
Landlord may select. 
  
 “Premises” means the
floor area more particularly shown on the floor plan attached hereto as Exhibit A, containing the approximate area of rentable square feet described on the Lease Summary. Landlord hereby reserves, for its sole and exclusive use, any and all
mechanical, electrical, telephone and similar rooms, janitor closets, elevator, pipe and other vertical shafts and ducts, flues and stairwells; the area above the acoustical ceiling, facilities serving parts of the Development other than the
Premises; and any other area not shown on Exhibit A as being part of the Premises. 
  
 “Related Parties” of a party means its employees, agents, contractors, officers, directors, partners, licensees, invitee and guests. 
  

 4 

 “Rent” means the Base Rent, Additional Rent, and any and all other charges of any nature
payable by Tenant to Landlord under this Lease. 
  
 “Rentable Area” means the number of square feet of the Premises and the Building, as applicable, set forth on the Lease Summary. 
  
 “Rules and Regulations” means the rules and regulations (as changed from time to time as therein provided) attached hereto as Exhibit E.

  
 “Tenant Parties” means the employees, agents,
contractors, officers, directors, partners, licensees, invitees and guests of Tenant. 
  
 “Tenant’s Share” means Rentable Area of the Premises divided by the greater of (a) ninety-five percent (95%) of the Rentable Area of the Building, or (b) the Rentable Area of the Building that is
actually occupied by tenants, as such area changes from time to time. The agreed-upon areas stated in this Lease (or in the Lease Commencement Certificate, if different) shall be used to determine Tenant’s Share unless either of said areas
materially changes. 
  
 “Term” means the period
commencing on the Commencement Date and ending on the Termination Date. 
  
 “Termination Date” means the date which is the number of Lease Years and months set forth on the Lease Summary after the Commencement Date or such earlier date upon which this Lease is terminated pursuant to the provisions
therein. Upon determination of the Commencement Date, Landlord and Tenant will execute a certificate in the form of Exhibit B specifying the Commencement Date and the Termination Date as determined with reference to the Lease Summary. 
  
 “Year or year” means a calendar year. 
  
 2.    DEMISE 
  
 For the Term, Landlord leases the Premises to Tenant and Tenant leases the
same from Landlord, all upon and subject to the terms and conditions of this Lease. Tenant hereby acknowledges that Landlord may deliver to Tenant either the Suite 950 Space or the Suite 980 Space prior to the Estimated Commencement Date, whereupon
the Lease shall commence with respect to the space so delivered upon all the terms, covenants and conditions contained in this Lease, including without limitation the obligation to pay Rent for the space so delivered. Tenant hereby acknowledges that
if Landlord, for any reason whatsoever, cannot deliver possession of the Premises to Tenant on the Commencement Date or upon the full execution of this Lease, which ever is later, this Lease shall not be void or voidable by Tenant, nor shall
Landlord be liable to Tenant for any loss or damage resulting therefrom; provided, however, if Landlord fails to deliver to Tenant possession of both the Suite 950 Space and the approximately two thousand one hundred thirty-eight (2,138) square feet
of rentable area (being a portion of Suite 900 of the Building) being concurrently subleased to Tenant (the “Sublease Premises”) on or before August 1, 1999, then Tenant may, at its option and as its sole and exclusive remedy for such
failure, terminate this Lease by delivering 
  

 5 

 
written notice of such termination to Landlord by August 10, 1999 but before Landlord delivers to Tenant possession of both the Suite 950 Space and the
Sublease Premises. If Tenant so terminates this Lease, then Landlord shall immediately return to Tenant all amounts previously paid by Tenant to Landlord under this Lease (and under the sublease of the Sublease Premises, if applicable), excluding
any amounts that Tenant may owe to Landlord pursuant to the terms of this Lease and excluding any portion of the Security Deposit used by Landlord to cure any defaults on the part of Tenant or otherwise used by Landlord in accordance with the
provisions of Section 6 of this Lease, and thereafter neither party shall have any further obligations under this Lease, other than those obligations that expressly survive the termination or earlier expiration of this Lease. If Tenant fails to so
terminate this Lease, this lease shall not terminate but shall remain in full force and effect upon the same terms and conditions set forth in this Lease. 
  
 If Landlord falls to deliver to Tenant possession of the Suite 980 Space on or before August 1, 1999, then, Tenant may, at is option and as its sole and
exclusive remedy for such failure, terminate this Lease for the Suite 980 Space by delivering written notice of such termination to Landlord by August 10, 1999 but before Landlord delivers to Tenant possession of the Suite 980 Space. If Tenant so
terminates this Lease for the Suite 980 Space, then Landlord shall immediately return to Tenant all amounts previously paid by Tenant to Landlord under this Lease for the Suite 980 Space, excluding any amounts that Tenant may owe to Landlord
pursuant to the terms of this Lease for the Suite 980 Space and excluding any portion of the Security Deposit for the Suite 980 Space used by Landlord to cure any defaults on the part of Tenant or otherwise used by Landlord in accordance with the
provisions of Section 6 of this Lease, and thereafter neither party shall have any further obligations under this Lease for the Suite 980 Space, other than those obligations that expressly survive the termination or earlier expiration of this Lease,
and if Tenant has not terminated the Lease in accordance with the provisions of the immediately foregoing paragraph of this Section 2, this Lease with regard to the Suite 950 Space shall remain in full force and effect upon the terms, covenants and
conditions specified in this Lease and thereafter the “Premises” shall mean the Suite 950 Space and all calculations based upon the square footage of the Premises shall be adjusted to include only the Suite 950 Space. If Tenant fails to
terminate this Lease for the Suite 980 Space in accordance with the provisions of this Section 2 and if Tenant has not terminated this Lease in accordance with the provisions of the immediately foregoing paragraph of this Section 2, then the Lease
for the Suite 980 Space (and for the Suite 950 Space) shall not terminate but shall remain in full force and effect upon the same terms and conditions set forth in this Lease. 
  
 So long as it is entitled to possess the Premises, Tenant may (with others) use the Common Areas on a non-exclusive basis
for their intended purposes; provided, however, Landlord shall have the sole and exclusive right to possession and control of the Common Areas. So long as reasonable access and services (including Tenant’s parking spaces described in the Lease
Summary) to the Premises are available, Landlord may (a) install, use, maintain, repair, relocate and replace pipes, duds, conduits, wires and appurtenant meters and equipment; (b) change the Common Areas, including, without limitation, the
location, size, shape and number of driveways, entrances, parking spaces, parking areas, loading and unloading areas, ingress, egress, direction of traffic, landscaped areas and walkways; (c) close temporarily, or eliminate permanently, any Common
Areas 
  

 6 

 
(d) designate other land as Common Areas; (e) add additional buildings and improvements to the Common Areas, and lease such buildings and improvements and/or
existing buildings and Improvements on the Common Areas; (f) use the Common Atlas in making expansions, additional improvements, repairs or alterations to any part of the Development; and (g) do and perform such other acts and make such other
changes in, to or with respect to the Development as Landlord may, in the exercise of sound business judgment, deem to be appropriate. 
  
 3.    ACCEPTANCE OF PREMISES 
  
 Tenant hereby acknowledges that the Premises is leased to Tenant in its present “as-is” condition, and Landlord
shall have no obligation to install any alterations, additions or improvements or do any work whatsoever to the Premises. Tenant further acknowledges that it is currently in possession of the Suite 950 Space pursuant to an assignment of that certain
Gateway Office Building Lease dated September 15, 1989, by and between Homart Development Co., a Delaware corporation, Landlord’s predecessor in interest, and Shakey’s Incorporated, a Delaware corporation (“Shakey’s”), as
amended (collectively, the “Shakey’s Lease”). Concurrently with the execution of this Lease, Landlord, Tenant and Shakey’s are executing an agreement terminating the Shakey’s Lease and the assignment thereof by Shakey’s
to Tenant (the “Shakey’s Lease Termination Agreement”). Notwithstanding anything to the contrary contained in this Lease, Tenant and Landlord hereby acknowledge that this Lease is expressly conditioned upon Tenant and Shakey’s
executing and delivering to Landlord the Shakey’s Lease Termination Agreement in a form reasonably acceptable to Landlord. If for any reason the Shakey’s Lease is not terminated pursuant to the Shakey’s Lease Termination Agreement,
this Lease shall terminate and thereafter neither party shall have any further obligation under this Lease, except for those obligations which by their terms survive the termination of this Lease. 
  
 The current tenant of the Suite 980 Space (the “Suite 980 Tenant”)
is executing a lease termination agreement (the “Suite 980 Lease Termination Agreement”), which Suite 980 Lease Termination Agreement shall terminate the current lease for the Suite 980 Space (the “Suite 980 Lease”). Tenant and
Landlord hereby acknowledge that this Lease as it relates to the Suite 980 Space only is expressly conditioned upon the Suite 980 Tenant’s executing and delivering to Landlord the Suite 980 Lease Termination Agreement in a form reasonably
acceptable to Landlord. If for any reason the Suite 980 Lease is not terminated pursuant to the Suite 980 Lease Termination Agreement, this Lease with respect to the Suite 980 Space only shall terminate and thereafter neither party shall have any
further obligation under this Lease for the Suite 980 Space, except for those obligations which by their terms survive the termination of this Lease, and this Lease with regard to the Suite 950 Space shall remain in full force and effect upon the
terms, covenants and conditions specified in this Lease and thereafter the “Premises” shall mean the Suite 950 Space and all calculations based upon the square footage of the Premises shall be adjusted to include only the Suite 950 Space.

  
 4.    RENT 
  
 From the Commencement Date, Tenant will pay Landlord, at the address
specified in the Lease Summary or at such other address as may be designated by Landlord from time to time and 
  

 7 

 
without prior notice, demand, offset or deduction (except as otherwise expressly set forth herein), the following rent: 
  
 4.1    Base Rent 
  
 Tenant shall pay the Base Rent in advance on the first day of each month
doing the Term hereof, except that the first full month’s Base Rent shall be paid upon execution of this Lease. If the Term commences on other than the first day of a month, the Base Rent provided for such partial month shall be prorated and
the prorated installment shall be paid on the first day of the calendar month succeeding the Commencement Date. If the Term terminates on other than the fast day of a calendar month, the Base Rent provided for such partial month shall be prorated
and the prorated installment shall be paid on the first day of the calendar month preceding the Termination Date. 
  
 4.2    Additional Rent 
  
 Tenant shall pay as additional rent (“Additional Rent”) Tenant’s Share of Operating Expenses in excess of the Operating Expense Base
multiplied by the Rentable Area. For partial years, the Operating Expenses will be calculated on a full-year basis, and then prorated. Tenant shall pay monthly installments of Additional Rent on the first day of each month, in amounts specified in
good faith by Landlord from time to time, which, by the end of each year (or by the Termination Date, if earlier), will total Landlord’s estimate of Additional Rent paid for such year. By the following April 1, or as soon thereafter as
practicable, Landlord will furnish Tenant a statement of Operating Expenses and Additional Rent for such year. Any amounts owing for that year shall, within thirty (30) days thereafter, be paid by Tenant to Landlord. Any amounts overpaid shall, at
Landlord’s option, be credited against the next installment(s) of Additional Rent due from Tenant, or be refunded to Tenant. This obligation survives termination or the earlier expiration of this Lease. 
  
 5.    SECURITY DEPOSIT 

 
 Concurrently with execution hereof, Tenant shall pay to Landlord the
Security Deposit set forth on the Lease Summary as security for the full and faithful performance of Tenant’s obligations under this Lease, which amount shall be paid as follows: Landlord shall credit to the Security Deposit the amount of
Twelve Thousand Two Hundred Thirty-Six and 40/100ths Dollars ($12,236.40), which Tenant paid to Landlord as a security deposit pursuant to the Shakey’s Lease; and Tenant shall pay to Landlord the amount of Fifteen Thousand Nine Hundred
Eighty-One and 45/100ths Dollars ($15,981.45). Landlord may (but shall not be required to) use the Security Deposit or any portion thereof to core any defaults on the part of Tenant or to compensate Landlord for any damage Landlord incurs as a
result of Tenant’s failure to perform any of its covenants or obligations hereunder, it being understood that any use of the Security Deposit shall not constitute a bar or defense to any of Landlord’s remedies under this Lease, at law or
in equity. In such event, and upon written notice from Landlord to Tenant specifying the amount of the Security Deposit so utilized by Landlord and the particular purpose for which such amount was applied, Tenant shall immediately deposit with
Landlord an amount sufficient to return the Security Deposit to the amount specified in the Basic Lease Information. Upon termination or earlier expiration of this Lease, the Security Deposit shall be returned to Tenant, reduced by those amounts
that may be required by 
  

 8 

 
Landlord to remedy defaults on the part of Tenant in the payment of Rent, to repair damage to the Premises caused by Tenant or Tenant Parties and to clean
the Premises to a broom-clean condition. The portion of the Security Deposit not so required shall be paid over to Tenant promptly after expiration of the Term. Landlord shall hold the Security Deposit for the foregoing purposes; provided, however,
that Landlord shall have no obligation to segregate the Security Deposit from its general funds or to pay interest thereon. If Landlord conveys or transfers its interest in the Building, and as a part of such conveyance or transfer, assigns its
interest in this Lease and Security Deposit and the transferee assumes the same in writing, or any portion thereof not previously applied, the Security Deposit shall be transferred to Landlord’s successor and Landlord shall be released and
discharged from any further liability to Tenant with respect to such Security Deposit. In no event shall any Mortgagee under a Mortgage, or any purchaser of all or any portion of the Development at a public or private foreclosure sale under a
Mortgage, have any liability or obligation whatsoever to Tenant or Tenant’s successors or assigns for the return of all or any part of the Security Deposit in the event any such Mortgagee or purchaser becomes a mortgagee in possession or
succeeds to the interest of Landlord under this Lease unless, and then only to the extent that, such Mortgagee or purchaser has received all or any part of the Security Deposit. 
  
 6.    SERVICES PROVIDED BY LANDLORD 
  
 Landlord agrees to furnish or cause to be furnished to the Premises the
utilities and services as described in Exhibit C, subject to the standards set forth therein. Tenant shall obtain all utilities and services from vendors designated by Landlord, which vendors shall be selected in Landlord’s sole and absolute
discretion, and Tenant shall have no right to obtain any utilities or services from any vendors other than those so designated by Landlord; provided, however, in no event shall Tenant be responsible for any charges from such venders in excess of the
costs charged by similar, reputable venders of such services to buildings in the Northern San Mateo County area comparable to the Building and otherwise consistent with an arms’-length agreement In the event any rule or regulation of applicable
utilities or governmental authority restricts the services to be provided hereunder, Landlord shall not be in default hereof and Tenant shall not be entitled to an abatement of Rent. Landlord does not warrant that the services provided for in this
Section 6 will be free from any irregularity or stoppage. Landlord shall use commercially reasonable efforts to correct the same, but no such condition or event will curate any liability for Landlord or Landlord Parties, or constitute an eviction,
actual or constructive, of Tenant, or cause any abatement of the rent payable under this Lease or relieve Tenant of any of its obligations under this Lease. Notwithstanding any other provision in this Paragraph 6 to the contrary, if such utilities
or services shall, by reason of Landlord’s negligence or willful misconduct and through no fault of Tenant, be interrupted or suspended and not restored within three (3) business days after written notice from Tenant to Landlord, and if by
reason of such interruption or suspension Tenant is unable to conduct its business operations from the Premises, then Landlord shall refund to Tenant an amount equal to the Base Rent (prorated on a daily basis) paid by Tenant for the period from the
date of such interruption or suspension until such service is restored or reasonably satisfactory alternative service is provided in its place. 
  

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 7.    USE; HAZARDOUS SUBSTANCES 
  
 7.1    Use of Premises 
  
 Tenant will use and occupy the Premises only for the purpose set forth in the
Lease Summary and no other purpose whatsoever, using and maintaining them in a clean, careful, safe, sanitary and proper manner. Tenant will pay for any damage to any part of the Development caused by any negligence, willful act, misuse or abuse by
Tenant or Tenant Parties. Tenant and Tenant Patties will comply with the Building’s Rules and Regulations and will not cause anywhere in the Development, or permit in the Premises, (a) any activity or thing (i) contrary to applicable law,
ordinance, regulation, restrictive covenant, or insurance regulation, including, without limitation, the Americans with Disabilities Act, 42 U.S.C. § 12101 et seq. and any governmental regulations relating thereto, including any required
alterations for purposes of “public accommodations” under such statute; or (ii) which jeopardizes the coverage of normal insurance policies or increase their cost; (b) defacing or injury to the Development; (c) waste or nuisance, or any
activity causing noise or odors perceptible outside the Premises; (d) cooking or heating food, except for incidental use, solely for Tenant Parties, of microwave ovens and beverage-brewing devices, provided that the foregoing do not use a flame and
are approved by Underwriters Laboratories for residential use; (e) sale, purchase or gift of any merchandise or storage therefor, including, without limitation, any use of vending machines (except for the use of those vending machines approved by
Landlord in writing, which approval shall not be unreasonably withheld); or (f) overloading of the floors or any of the structural or mechanical systems of the Building. Tenant shall not erect or place any item in or upon the Common Areas. Tenant
will conduct its business and occupy the Premises and shall not unreasonably interfere with, annoy or disturb any other tenants in the Development or the Landlord in its management thereof. Tenant shall not erect or place any item (including,
without limitation, signs) in, upon or visible from the exterior of the Building or the Common Areas of the Development; provided, however, Tenant shall be entitled to maintain its existing sign on the temporary monument sign of the Development at
its sole cost and expense until such time that Landlord removes the monument sign from the Development, in its sole and absolute discretion, and thereafter Tenant shall have no further right to erect or place any sign in, upon or visible from the
exterior of the Building or the Common Areas of the Development. 
  
 7.2    Hazardous Substances 
  
 Tenant shall not generate, use, manufacture, keep, store, refine, release, discharge or dispose of any substance or material that is described as a toxic or hazardous substance, waste or material or a pollutant or contaminant by any
federal, state or local law, ordinance, rule or regulation now or hereafter in force, as amended from time to time, in any way relating to or regulating human health or safety or industrial hygiene or environmental conditions or pollution or
contamination, including, without limitation, the Comprehensive Environmental Response, Compensation and Liability Act of 1980, 42 U.S.C. § 9601, et seq., the Solid Waste Disposal Act, 42 U.S.C. § 6901, et seq., the Hazardous Substance
Account Act, California Health and Safety Code § 25300, et seq., the Hazardous Waste Control Law, California Health and Safety Code § 25100, et seq., and the Porter-Cologne Water Quality Control Act, California Water Code § 13000, et
seq., including, without 
  

 10 

 
limitation, PCBs, petroleum products, asbestos and asbestos-containing materials (collectively, “Hazardous Substances”), on, under or near the
Development, except that Tenant may use Hazardous Substances on the Premises that are incidental to and only in quantities reasonably required for general office use, such as photocopier toner and household cleaner, provided such use is in full
compliance with all applicable laws and prudent business practices. Except as specifically provided above, Tenant shall ensure that Tenant and Tenant’s Parties shall not cause or permit any waste material or refuse to be dumped upon or remain
upon any part of the Development, and Tenant shall ensure that Tenant and Tenant’s Parties shall not cause or allow any materials, supplies, equipment, finished products or semi-finished products or articles of any nature to be stored upon or
remain upon the Development. Tenant shall Indemnify, defend and hold Landlord and Landlord Parties harmless from any and all Liabilities (as defined in Section 14), incurred in connection with or arising from the generation, use, manufacture,
keeping storage, refinement, release, discharge or disposal of any Hazardous Substances by Tenant, any Tenant Parties or any person claiming through or under Tenant or any Tenant Party on or about the Development. The foregoing indemnity shall
survive termination or earlier expiration of this Lease. 
  
 8.    BROKERS 
  
 Tenant warrants that it has had no dealing with any broker or agent other than the Broker specified in the Lease Summary in connection with this Lease. Tenant hereby acknowledges that it is solely responsible for the payment of any
commissions or other compensation or charges claimed by Broker (“Broker Fees”); provided, however, Landlord hereby acknowledges that Tenant shall be entitled to use a portion of the Allowance (as defined in Section 10.2, below) for the
payment of any Broker Fees owing in connection with this Lease. Tenant shall indemnify, defend and hold Landlord and Landlord Parties harmless from and against any and all Liabilities for commissions or other compensation or charges claimed by any
other broker or agent based on dealings with Tenant with respect to this Lease. Landlord warrants that it has had no dealings with any broker or agent in connection with this Lease. Landlord shall indemnify, defend and hold Tenant and Tenant Parties
harmless from and against any and all Liabilities for commissions or other compensation or charges claimed by any broker or agent based on dealings with Landlord with respect to this Lease. The foregoing indemnities shall survive termination or
earlier expiration of this Lease. 
  
 9.    TENANT’S TAXES 
  
 (a)    In addition to Tenant’s obligations under Section 4.2, Tenant shall be responsible for and shall pay, at least ten (10)
days before delinquency, all taxes, fees or charges levied or assessed against or attributable to any personal property or trade fixtures in the Premises or by reason of leasehold improvements. If any such taxes, fees or charges are included in
Landlord’s taxes, Landlord may pay them regardless of the validity (under proper protest, if requested by Tenant and at Tenant’s sole cost and expense), and Tenant will pay Landlord the amount of Landlord’s taxes attributable to
Tenant; as determined in good faith by Landlord, within thirty (30) days after Landlord delivers to Tenant written demand supported by reasonably satisfactory evidence of the taxes attributable to Tenant. 
  

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 (b)    In addition to all other sums to be paid by Tenant under this Lease, Tenant
shall pay, before delinquency, any and all taxes levied or assessed during the Term, whether or not now customary or within the contemplation of the parties hereto, (i) upon or measured by Base Rent or Additional Rent, or both, payable under this
Lease, including, without limitation, any gross income tax or excise tax levied by the city and/or county in which the Building is located, the State of California, the Federal Government or any other governmental body with respect to the receipt of
such rental; (ii) upon or with respect to the possession, leasing, operation, management, maintenance, alteration, repair, use or occupancy by Tenant of the Premises or any portion thereof; or (iii) upon this transaction or any document to which
Tenant is a party creating or transferring an interest or an estate in the Premises. 
  
 10.    ALTERATIONS, REPAIRS AND MAINTENANCE 
  
 10.1    Repairs and Maintenance 
  

(a)    Subject to Sections 4.2, 10.1(6), 17 and 18, Landlord shall repair and maintain (i) the structural portions of the Building,
(ii) the exterior walls of the Building, including glass and glazing, (iii) the roof, (iv) those portions of the mechanical, electrical, plumbing. HVAC and life safety systems serving the Building (the “Systems”) (excluding any connections
or elements thereof installed by Tenant) and (v) the Common Areas. Any repair caused in part or in whole by the act, neglect or omission of Tenant or any Tenant parties shall be made by Landlord at the sole cost and expense of Tenant. 
  
 (b)    Throughout the Term, Tenant shall at its sole cost
and expense (i) keep, maintain and repair the Premises in first class condition and repair, ordinary wear and tear and damage from any casualty or condemnation for which Tenant is not responsible or liable under the Lease excepted, (ii) make all
nonstructural repairs and replacements to the Premises, and (iii) keep, maintain and repair all Systems installed by Tenant, fixtures and supplemental HVAC units in good working order, unless Landlord elects, at Tenant’s sole cost and expense,
to perform such work. In performing the obligations under this Section 10.1(b), Tenant shall notify Landlord of any repairs that could affect the Systems serving the Building (exclusive of the Premises) and shall use contractors approved by
Landlord, in its reasonable discretion. Landlord shall have the right but not the obligation to undertake work that Tenant is required to perform under this Lease and that Tenant fails or refuses to perform in a timely and efficient manner. All
reasonable costs incurred by Landlord in performing any such maintenance or repair for the account of Tenant, together with an administrative fee equal to ten percent (10%) of such costs, shall be repaid by Tenant to Landlord within thirty (30) days
after Landlord delivers to Tenant written demand supported by invoices or other reasonably satisfactory evidence of such costs. 
  
 (c)    Subject to Section 6 and Section 17.3, there shall be no abatement of rent and no liability of Landlord by reason of any injury
to or interference with Tenant’s business arising from the making of any repairs, alterations or improvements in or to any portion of the Development, or in or to fixtures, appurtenances and equipment therein. Tenant waives the right to make
repairs at Landlord’s expense under any law, statute or ordinance now or hereafter in effect. 
  

 12 

 10.2    Alterations 
  
 Tenant will not make or permit alterations, improvements or additions
(including fixtures) in or to the Premises (collectively “Alterations”) without Landlord’s prior written consent, which consent shall not be unreasonably withheld. Tenant’s request for such consent shall be in writing,
accompanied by proposed detailed plans and specifications. Landlord may require Tenant to provide Landlord, at Tenant’s sole cost and expense, a lien and completion bond in an amount equal to one and one-half times the estimated cost of such
Alterations, to insure Landlord against any liability for any mechanic’s and materialmen’s liens and to insure completion of the work. Alterations will be performed, if Landlord elects, by Landlord or a contractor designated by Landlord,
at Tenant’s sole cost and expense. Tenant may engage its own contractors to perform remodel work upon written approval by Landlord. In such event, Landlord shall charge a fifteen percent (15%) administrative fee on all construction costs. Any
and all plans must be submitted to landlord for approval, and building permits must be obtained by Tenant prior to commencement of any construction remodeling. Subject to Section 24.1, all Alterations will become Landlord’s property and a part
of the Building without compensation to Tenant. Tenant will promptly notify Landlord of the value thereof for insurance purposes. Tenant shall indemnify, defend and hold Landlord and Landlord parties harmless from and against any and all Liabilities
incurred in connection with or arising from any work performed by or on behalf of Tenant. 
  
 If Landlord gives its consent to Tenant’s making such Alterations, the consent shall be deemed conditioned upon Tenant’s acquiring all permits and approvals required to lawfully do so from applicable
governmental agencies, furnishing a copy thereof to Landlord prior to the commencement of the work, and compliance by Tenant with all conditions of said permits and approvals in a prompt and expeditious manner. Unless Landlord so specifies when it
gives such consent, Tenant shall not be obligated to remove any Alterations upon the expiration or earlier termination of the Term. Tenant shall give Landlord not less than ten (10) days notice prior to the commencement of any work in the Premises
by Tenant, and Landlord shall have the right to post notices of non-responsibility in or on the Premises or other parts of the Development as provided by law. All Alterations, repairs and replacements by Tenant shall be in accordance with all
applicable laws, rules and ordinances and the requirements of any insurance carrier, and shall be of a quality and class at least equal to the original work, performed in a good and workmanlike manner with good grades of materials approved by
Landlord. Tenant will give Landlord opportunity to inspect and monitor all work. Tenant shall provide Landlord with as-built plans and specifications for Alterations promptly upon their completion. Should Tenant make any Alterations without
Landlord’s prior written approval, or in violation of such approval or the requirements of this Section 10.2, Landlord may, at any time during the Term, either remove any part or all of the same on Tenant’s behalf or require that Tenant do
so all at Tenant’s sole cost and expense. All reasonable costs incurred by landlord in removing any such alterations shall be repaid by Tenant to Landlord immediately upon demand, together with an administrative fee equal to fifteen percent
(15%) of such costs. 
  
 Subject to the teens of this Section
10.2, Landlord hereby consents to Tenant (i) upon delivery to Tenant of both the Suite 950 Space and the Sublease Premises, removing the current 
  

 13 

 
demising wall that separates the Suite 950 Space from the Sublease Presses (the “Sublease Demising Wall”), (ii) upon delivery by Landlord to Tenant
of both the Suite 950 Space and the Suite 980 Space, removing the current demising wall that separates the Suite 950 Space from the Suite 980 Space (the “Suite 980 Demising Wall”) and (iii) making minor Alterations that may be required in
connection with the removal of each of the Sublease Demising Wall and the Suite 980 Demising Wall (collectively, the “Demising Alterations”); provided, however, and notwithstanding anything to the contrary contained herein, upon the
expiration or earlier termination of the Term, Tenant, at Landlord’s request, shall remove any Demising Alterations and repair any damage to the Suite 950 Space, the Sublease Premises and/or the Suite 980 Space as a result of the Demising
Alterations and Tenant shall reconstruct the Sublease Demising Wall and the Suite 980 Demising Wall each to the same condition in which each existed at the commencement of the Term. Landlord hereby agrees to reimburse Tenant for the out-of-pocket
costs Tenant actually incurs for the Demising Alterations and for any Broker Fees as set forth in Section 8, but in no event shall Landlord’s reimbursement obligation pursuant hereto, in the aggregate, exceed Thirty Thousand Dollars
($30,000.00) (the “Allowance”). All costs in excess of the Allowance shall be the sole responsibility of Tenant. Landlord shall make such reimbursement to Tenant within thirty (30) days after Tenant delivers to Landlord written demand
supported by invoices, receipts and other documents reasonably acceptable to Landlord as evidence of the lien-free completion of said improvements in accordance with the provisions of this Lease and all applicable laws and as evidence of the payment
of Broker Fees by Tenant, as applicable. Any and all costs not properly submitted to Landlord by May 31, 2000 shall not be reimbursable hereunder and shall be at Tenant’s sole cost and expense. Any excess allowance not properly claimed by
Tenant pursuant hereto shall, after May 31, 2000, be forfeited by Tenant and remain the exclusive property of the Landlord. 
  
 11.    LIENS 
  
 Tenant shall not permit any lien to exist on or against any part of the Development allegedly resulting from any work or materials furnished or
obligations incurred by or for Tenant. Tenant shall discharge any such lien of record or post a bond in accordance with applicable law as soon as reasonably possible after such lien is filed; provided, however, if no liens are allowed pursuant to
Landlord’s Mortgage now or hereafter existing on any part of the Building or the Development, Tenant shall discharge any such lien of record immediately upon its filing. Neither this Lease, nor any request or consent of Landlord to the labor,
materials or obligations, shall be a consent to any such lien. Landlord may keep posted on the Premises any notices it deems necessary for protection from such liens. If Tenant fails to discharge any such lien, or to post a bond, or to contest such
lien by appropriate legal proceeding, or if any such lien jeopardizes Landlord’s interest in the Development or is otherwise prohibited by Landlord’s Mortgage now or hereafter existing on any part of the Building or the Development, then
Landlord may cause such lien to be released by any means it deems proper, including payment, at Tenant’s sole cost and expense and without affecting Landlord’s rights. All reasonable costs incurred by Landlord in causing such liens to be
released, together with an administrative fee equal to ten percent (10%) of such costs, shall be repaid by Tenant to Landlord within thirty (30) days after Landlord delivers to Tenant written demand supported by invoices or other reasonably
satisfactory evidence of such costs. 
  

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 12.    ENTRY 
  
 Landlord may enter any part of the Premises at all reasonable hours following reasonable prior notice to Tenant (or in any
emergency or suspected emergency, at any hour, without notice), to (a) inspect, test, clean, or make repairs, alterations and additions to the Building or the Premises as Landlord believes appropriate, or (b) provide any service which Landlord is
now or hereafter obligated to furnish to tenants of the Building, or (c) show the Premises to prospective lenders, purchasers or tenants (but, with respect to tenants, only during the last six (6) months of the Term) and, if they are vacated, to
prepare them for reoccupancy. Rent will not abate because of Landlord’s entry. Landlord shall at all times have keys to all doors to or in the Premises. 
  
 13.    LANDLORD’S LIABILITY 
  
 Tenant will protect its property and the person and property of all Tenant Parties, and insure the same to its own
satisfaction (including at least the insurance required hereunder), and accordingly waives any claim against Landlord and the Landlord Parties for loss or damage to any property, injury to any person, or injury to Tenant’s business from any
cause except for any damages directly caused (and specifically excluding any consequential damages) by Landlord’s willful misconduct or reckless ads. Tenant, for itself and all Tenant Parties, assumes all risk of damage to person and property,
proximate or remote. All personal property on the Premises is at Tenant’s risk only; the Landlord shall not be liable for any damage to or theft of such property. 
  
 14.    INDEMNIFICATION AND EXCULPATION 
  
 Tenant shall indemnify, defend and hold Landlord and the Landlord Parties
(collectively, “Indemnitee”) harmless from and against any and all fines, suits, losses, costs, expenses, liabilities, claims, demands, actions, damages and judgments (collectively, “Liabilities”) suffered by, recovered from or
asserted against the Indemnitee, of every kind and character, resulting from any breach, violation or nonperformance by Tenant of any provision of this Lease, and from injury or damage to person or property incident to, arising out of or caused
(proximately or remotely, in whole or in part) by any act, omission, negligence or misconduct by Tenant or the Tenant Parties, or in any other way from Tenant or any Tenant Parties’ occupancy or use of or presence on the Development. If any
such proceeding is brought against an Indemnitee, Tenant will retain counsel reasonably satisfactory to Landlord to defend the Indemnitee at Tenant’s sole cost and expense. All such costs and expenses, including, without limitation,
attorneys’ fees and court costs, shall be payable by Tenant to Landlord immediately upon demand. Tenant’s obligations under this Section 14 shall survive the termination or earlier expiration of this Lease. 
  
 Landlord will indemnify, defend and hold Tenant harmless from all Liabilities
asserted against Tenant, to the extant that such Liabilities are proven by Tenant to have been caused by Landlord’s willful misconduct or reckless acts. Landlord’s obligations under this Section 14 shall include reimbursement to Tenant for
reasonable attorneys’ fees and court costs incurred by Tenant in connection with those Liabilities covered by Landlord’s indemnification as set forth herein. All costs and expenses, including attorneys’ fees and court costs, payable
by Landlord to Tenant under this Section 14 shall be payable to Tenant within thirty (30) days after Tenant delivers to Landlord 
  

 15 

 written demand supported by invoices or other reasonably satisfactory evidence of such expenses. Landlord’s
obligations under this Section 14 shall survive the termination or earlier expiration of this Lease. 
  
 15.    INSURANCE 
  
 Tenant, during the Term and any other period of occupancy, will at its sole cost and expense maintain insurance reasonably satisfactory to Landlord, but in any event complying with the following minimum requirements:

  
 (a)    General Liability insurance with
combined single limits not less than $2,000,000.00, for personal injury or death and property damage occurring in or about or related to the use or occupancy of the Development by Tenant and any Tenant Parties. 
  
 (b)    “All Risk” insurance for the full
replacement cost of all Alterations, all Tenant’s property on the Premises and all fixtures. Unless this lease is terminated upon damage or destruction, the proceeds of such insurance will be used to restore the foregoing. 
  
 (c)    Worker’s Compensation (as required by state
law), and Employer’s Liability insurance in the amount of not less than $500,000.00. 
  
 (d)    Loss of income and extra expense insurance in such amounts as will reimburse Tenant for direct or indirect loss of earrings or extra expenses attributable to all perils commonly insured
against by prudent tenants or attributable to prevention of access to the Development as a result of such perils. 
  
 All policies required hereunder will be issued by carriers rated A-VII or better by Best’s Key Rating Guide and licensed to do business in the State
of California. The policies shall name Landlord and any other person or entity that Landlord may designate from time to time as additional insureds, with primary coverage non-contributing to any insurance Landlord may carry, and shall provide that
coverage cannot be cancelled or materially changed except upon thirty (30) days prior written notice to Landlord and any additional insureds. At least thirty (30) days prior to expiration of such policies, and promptly upon any other request by
Landlord, Tenant shall furnish Landlord and any additional insureds with copies of policies, or certificates of insurance, evidencing maintenance and renewal of the required coverage. In the event Tenant does not maintain said insurance, Landlord
may, in its sole discretion and without waiving any other remedies hereunder, procure said insurance and Tenant shall pay to Landlord within thirty (30) days after written demand the cost of said insurance together with an administrative fee equal
to ten percent (10%) of such costs. 
  
 During the Term Landlord
shall insure the Building (excluding any property which Tenant is obligated to insure) against damage with All-Risk insurance and public liability insurance, all in such amounts and with such deductibles as Landlord in good faith considers
appropriate; provided, however, such All-Risk insurance shall be in an amount equal to at least the full replacement cost of the Building. Landlord may, but shall not be obligated to, obtain and carry any other form or forms 
  

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 of insurance, including, without limitation, earthquake insurance (subject to the provisions of subparagraph (h) of the
definition of Operating Expenses), as Landlord or Mortgagees may determine advisable. Tenant has no right to receive any proceeds from any insurance policies carried by Landlord. Notwithstanding anything in the foregoing to the contrary; however,
Landlord may self-insure but only to the extent permitted under any Mortgage. 
  
 If any act or acts, occupancy or use by Tenant or any Tenant Parties, whether or not Landlord has consented to the same, increase the cost of Landlord’s insurance, Tenant will pay the full cost of any such
increase along with Additional Rent. A schedule issued by the organization computing the insurance rate shall be conclusive evidence of the cost of such increase in premium. If any of Landlord’s insurance is (or is threatened to be) cancelled
or the coverage thereunder reduced in any way because of any ad or acts, occupancy or use by Tenant or any Tenant Parties, Landlord may terminate this Lease and/or may enter upon the Premises at Tenant’s sole cost and expense and without any
liability to Tenant, and attempt to remedy such condition. All costs incurred by Landlord in performing any such remedial action shall be repaid by Tenant to Landlord within thirty (30) days after written demand, together with an administrative fee
equal to ten percent (10%) of such costs. 
  
 16.    NO SUBROGATION 
  
 All insurance policies which either party obtains, or is required to obtain hereunder, affecting the Premises shall include, if available from each party’s respective insurer upon commercially reasonable terms
and prices, a clause or endorsement denying the insurer any rights of subrogation against the other party. Landlord and Tenant waive any rights or recovery against the other for any actually insured injury or loss. 
  
 17.    DAMAGE OR
DESTRUCTION 
  
 If the Premises or any part
thereof is damaged by fire or other casualty, Tenant will promptly notify Landlord. 
  
 17.1    Cancellation of Lease; Restoration of Building. 
  
 If the Building or the premises or any significant portion of the Common Areas is damaged by fire or other casualty to the extent that, in Landlord’s
sole and absolute opinion, substantial alteration or reconstruction is required, or if any Mortgagee of a Mortgage requires that the insurance proceeds payable as a result of the fire or other casualty be applied against the indebtedness secured by
the Mortgage, Landlord may terminate this Lease by notifying Tenant within sixty (60) days after the later of the date the damage occurs or the date Landlord is so notified by its Mortgagee, in which event the Rent under this Lease will be equitably
abated as of the date of the fire or other casualty to the extent such damage materially impairs Tenant’s business operations at the Premises. If this Lease is not terminated, then within seventy- five (75) days after the fire or other
casualty, or such greater period as may be reasonably necessary, Landlord will commence to repair and restore the Premises and any portion of the Building and Common Areas acquired for access to the Premises, and will diligently complete the same,
but Landlord shall not be required (a) to expend more for such 
  

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 repair of the Premises than the insurance proceeds in Landlord’s possession (or to be disbursed to Landlord pursuant
to the Mortgage) that exceed the proceeds retained (or required to be retained) by Mortgagee pursuant to its Mortgage and that are reasonably allocable to the Premises, or (b) to rebuild, repair or replace any of Tenant’s furniture,
furnishings, fixtures or equipment removable by Tenant under the provisions of this Lease or which Tenant has insured or is required to insure under the provisions of this Lease. If the Premises (or access thereto) is damaged by fire or other
casualty so as to unreasonably interfere with Tenant’s use and enjoyment of the Premises for Tenant’s normal business operations and Landlord reasonably determines that it will be unable to repair that portion of the Premises (or access
thereto) for which Landlord is responsible hereunder within two hundred seventy (270) days after such fire or other casualty, then Landlord shall deliver written notice to Tenant within sixty (60) days after such fire or other casualty informing
Tenant of Landlord’s inability to so repair the Premises (or access thereto) within said two hundred seventy (270) day period and Tenant shall have ten (10) days from the date of such notice during which to terminate this Lease by delivering to
Landlord written notice of Tenant’s desire to so terminate the Lease. If Tenant does not timely elect to so terminate this Lease, this Lease shall remain in full force and effect. 
  
 17.2    Casualty Loss During Last Year of Lease 
  
 If the Premises or the Building is damaged by fire or other casualty during
the last six (6) months of the Term, whether or not the damage requires substantial repair and reconstruction, either Tenant or Landlord may cancel this Lease as of the date of the tire or casualty by notice to the other within thirty (30) days
thereafter. 
  
 17.3    Abatement of
Rent 
  
 In the event of any damage described in this
Section 17, Base Rent shall be equitably abated in proportion to the extent that Tenant’s business operations at the Premises are impaired, such abatement to commence as of the date such damage occurs and will continue during the period of such
repairs. Except as expressly provided to the contrary in this Lease, this Lease will not terminate, and Tenant will not be entitled to damages or to any abatement of Rent, as a result of a fire or other casualty, repair or restoration. The
provisions of California Civil Code Sections 1932(2) and 1933(4) which permit termination of a lease upon destruction of Premises, and any other present or future statute that may so permit, are hereby waived by Tenant. 
  
 18.    CONDEMNATION 
  
 If all or substantially all of the Building or of the Premises or of the
parking areas in the Common Areas is taken for any public or quasi-public use under any governmental law, ordinance or regulation or by right of eminent domain or is sold to the condemning authority in lien of condemnation, then this Lease will
terminate on the earlier of the date title thereto passes to the condemning authority or when physical possession is taken by the condemning authority. If a lesser but material portion of the Building or Common Areas is thus taken or sold (whether
or not the Premises are affected thereby), then either Tenant (if the taking renders the Building and the Premises unsuitable for Tenant’s continued use of the Premises) or Landlord may terminate this 
  

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Lease by notice to the other within sixty (60) days after the taking or sale, in which event this Lease will terminate on the earlier of the date title
thereto passes to the condemning authority or when physical possession of the applicable portion of the Building, the Common Areas or the Premises is taken by the condemning authority. If this Lease is not terminated pursuant to the foregoing and a
portion of the Premises has been taken or sold, the Base Rent and Tenant’s Share shall be adjusted according to the Rentable Area of the Premises remaining after such taking or sale, and Landlord, at its sole expense, will restore the affected
portion of the Building to substantially its former condition as far as feasible, but not beyond the work done by Landlord in originally constructing the affected portion of the Building and installing tenant improvements in the Premises. However,
Landlord shall not be required to expend more for any restoration of the Premises than the Premises’ allocable share of the net compensation or damages received by Landlord for the part of the Building taken and which compensation or damages
have been or will be released to landlord by Mortgagee. Landlord will be entitled to receive all of the compensation awarded upon a taking of any part or all of the Development, including, without limitation, any award for any unexpired term of this
Lease and Tenant hereby assigns such compensation so awarded to Landlord. Notwithstanding the foregoing, Tenant may seek an award in separate proceedings for its personal property, trade fixtures, moving expenses and good will. 
  
 In the event of a taking or sale of the Premises or any part thereof for
temporary use, this Lease shall remain unaffected and Rent shall not abate, and Tenant shall be entitled to such portion or portions of any award made for such use with respect to the period of the taking which is within the Term, provided that, if
such taking shall remain in force at the expiration or earlier termination of this Lease, Tenant shall then pay to Landlord a sum equal to the reasonable cost of performing Tenant’s obligations with respect to surrender of the Premises.

  
 To the extent that it is inconsistent with the provisions of
this Section 18, each party hereto hereby waives the provisions of Section 1265.130 of the California Code of Civil Procedure allowing either party to petition a court to terminate this Lease in the event of a partial taking of the Premises.

  
 19.    DEFAULTS AND
REMEDIES 
  
 19.1    Events of Default 
  
 The occurrence of any one or more of the following events shall constitute a default hereunder by Tenant: 
  
 (a)    Tenant fails to make a payment within five (5) days after written notice that such payment is due hereunder; provided, however,
that Landlord shall not be required to provide such notice more than twice during the Term with respect to Base Rent or Additional Rent, the third such non-payment constituting default without requirement of notice; or 
  
 (b)    Tenant attempts any Assignment (as defined in
Section 20) except as expressly permitted pursuant to Section 20; or 
  

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 (c)    Tenant fails to comply with any other obligation under this Lease and does not
cure such failure as soon as reasonably practicable and in any event within twenty (20) days after written notice; 
  
 provided, however, if such failure cannot be cured during such twenty (20) day period, Tenant shall not be in default hereunder so long as Tenant commences to cure such
failure within that twenty (20) day period and thereafter diligently completes such cure; or 
  
 (d)    Tenant or any Guarantor becomes insolvent, makes a transfer in fraud of creditors or an assignment for the benefit of creditors, admits in writing its inability to pay its debts as they
become due, or files a petition under any Section or Chapter of the United States Bankruptcy Code or any similar law or statute; or an order for relief is entered with respect to Tenant or any Guarantor in any bankruptcy, reorganization or
insolvency proceedings; or a pleading seeking such an order is not discharged or denied, within sixty (60) days after its filing; or any action is taken at the corporate, partnership or company level by Tenant or any Guarantor to authorize any of
the foregoing actions on behalf of Tenant or any Guarantor; or a receiver or trustee is appointed for all or substantially all of the assets of Tenant or any Guarantor or of the Premises or any of Tenant’s property located thereon in any
proceedings brought by Tenant or any Guarantor, or any receiver or trustee is appointed in any proceeding brought against Tenant or any Guarantor and not discharged within sixty (60) days after appointment or Tenant or any Guarantor does not contest
such appointment; or any part of Tenant’s estate under this Lease is taken by process of law in any action against Tenant; or 
  
 (e)    Tenant abandons the Premises; or 
  
 (f)    Three (3) times within a year, Tenant fails to fulfill a monetary obligation or a material non-monetary obligation under this
Lease but thereafter cures such failure within the time provided. 
  
 Any notice specified above shall serve as, and not be in addition to, any notice required under California Code of Civil Procedure Section 1161 or otherwise regarding unlawful detainer actions. 
  
 19.2    Remedies 
  
 (a)    Upon an event of default, Landlord shall have the
immediate option to terminate this Lease and all rights of Tenant hereunder by-giving written notice to Tenant of such termination. If and when this Lease is so terminated, all rights of Tenant and those claiming under it will terminate and Landlord
may immediately recover from Tenant: 
  
 (i)    The worth at the time of award of any unpaid Rent which had been earned at the time of such termination; plus 
  
 (ii)    The worth at the time of award of the amount by which the unpaid Rent which would have been earned after termination entail
the time of award exceeds the amount of such rental loss that Tenant proves could have been reasonably avoided; plus 
  

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 (iii)    The worth at the time of award of the amount by which the unpaid Rent for
the balance of the term after the time of award exceeds the amount of such rental loss that Tenant proves could be reasonably avoided; plus 
  
 (iv)    Any other amount necessary to compensate Landlord for all the detriment proximately caused by Tenant’s failure to
perform Tenant’s obligations under this Lease or which in the ordinary course of things would be likely to result therefrom. 
  
 As used in Subsections (i) and (ii) above, the “worth at the time of award” is computed by allowing interest at the maximum rate permitted by
law. As used in Subsection (iii) above, the “worth at the time of award” is computed by discounting such amount at the discount rate of the Federal Reserve Bank of San Francisco at the time of award plus one percent (1%). 
  
 (b)    Pursuant to California Civil Code Section 1951.4,
Landlord shall have the right to continue this Lease in full force and effect and this Lease shall continue in full force and effect as long as Landlord does not terminate Tenant’s rights to possession of the Premises and Landlord shall have
the right to collect Rent when due. Until this Lease is so terminated, Landlord may, on Tenant’s behalf, at Tenants sole cost and expense and in Landlord’s sole discretion, sublet any of the Premises (and, on expiration or earlier
termination of the sublease, may re-sublet) for all or part of the remainder of the Term, on whatever terms and conditions Landlord in its sole and absolute discretion deems advisable. Against the Rent and sums due from Tenant to Landlord during the
remainder of the Term, credit will be given Tenant in the net amount of Rent received from the new tenant but only after deduction by Landlord for (a) the costs incurred by Landlord in reletting the Premises (including, without limitation, repair
and remodeling costs, brokerage fees, legal fees and the like), and (b) all accrued scams, plus interest and late charges, under the terms of this Lease. 
  
 (c)    Upon an event of default or when Tenant is no longer entitled to possession, Landlord may enter the Premises and dispose of
Tenant’s property in accordance with law, and may perform Tenant’s obligations hereunder on Tenant’s behalf, Tenant will reimburse Landlord immediately on demand for Landlord’s attorneys’ fees and other expenses in doing so.
This Section 19.2(c) shall survive expiration or earlier termination of this Lease. 
  
 19.3    Continuing Liability 
  
 No repossession, re-entering or reletting of file Premises or any part thereof by Landlord shall relieve Tenant or any Guarantor of its liabilities and obligations under this Lease. 
  
 19.4    Remedies Cumulative 
  
 All rights and remedies of Landlord under this Lease will be non-exclusive of
and in addition to any other remedies available to Landlord at law or in equity. 
  

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 19.5    No Waiver 
  
 Either party’s failure to insist on strict compliance with any terms
hereof or to exercise any right or remedy, does not waive the same. Waiver of any agreement regarding any breach does not affect any subsequent or other breach, unless so stated. A receipt by Landlord of any Rent with knowledge of the breach of any
covenant or agreement contained in this Lease shall not be a waiver of the breach, and no waiver by either party of any violation or provision of this Lease shall be effective unless expressed in writing and signed by such party. Payment by Tenant
or receipt by Landlord of a lesser amount than due under this Lease may be applied to such of Tenant’s obligations as Landlord elects. No endorsement or statement on any check, and no accompanying letter, shall make the same an accord and
satisfaction, and Landlord may accept any check or payment without prejudice to Landlord’s right to recover the balance of the Rent or pursue any other remedy provided in this Lease. 
  
 20.    ASSIGNMENT OR SUBLEASE 
  
 20.1    Notification 
  
 If Tenant intends to assign, transfer, or encumber this Lease or any estate
or interest herein, or permit the same too occur, or sublet or grant any right of occupancy for any part of the Premises or permit such occupancy by any other parties other than Tenant and any Tenant Parties, or modify or terminate any agreement for
any of the foregoing (the foregoing collectively referred to as an “Assignment,” and the other party thereto the “Assignee”), Tenant shall give Landlord written notice of such intent. Tenant’s notice shall be accompanied by
an exact copy of the proposed agreements between Tenant and the proposed Assignee. Tenant shall provide landlord with (a) any additional information or documents reasonably requested by Landlord within ten (10) days after receiving Tenant’s
notice, and (b) an opportunity to meet and interview the proposed Assignee, if requested. 
  
 20.2    Landlord Approval 
  
 Landlord shall then have a period of twenty (20) days following such Interview and receipt of such additional information (or thirty (30) days from the date of Tenant’s original notice if Landlord does not
request additional information or an interview) within which to notify Tenant in writing that Landlord elects, in its sole and absolute discretion, either (a) to terminate this Lease as to the space so affected as of the date so specified by Tenant,
in which event Tenant will be relieved of all further obligations hereunder as to such space arising from and after such termination except for those obligations which by their terms survive termination or earlier expiration of this Lease, or (b) to
permit the Assignment, subject, however, to prior written approval of the proposed Assignee by Landlord, such consent not to be unreasonably withheld so long as (i) the use of the Premises by such Assignee would be in accordance with Section 7.1
hereof (ii) the proposed Assignee is of sound financial condition as determined by Landlord in its good faith discretion, (iii) the Assignee would not cause the violation of any covenant or agreement of Landlord to any third party or would permit
any other tenant to terminate its lease, and (iv) the Assignee does not then lease or occupy any other space in the Development. If Landlord fails to notify Tenant in writing of its election within said period, Landlord shall be deemed to have
waived option (a) above, but written approval by Landlord 
  

 22 

 
of the proposed Assignee shall nonetheless be required in accordance with (b) above. Failure by Landlord to approve a proposed Assignee shall not cause a
termination of this Lease. If Tenant’s obligations under this Lease have been guaranteed by one or more Guarantors, then an Assignment, and Landlord’s consent thereto, shall not be effective unless the Guarantors give their written consent
to such Assignment and the terms thereof and explicitly agree in writing that the Guaranty shall remain in full force and effect notwithstanding such Assignment. 
  
 20.3    Allocation of Excess Rent 
  
 Any rent or other consideration realized by Tenant under any Assignment in
excess of the Rent payable hereunder, after amortization of the reasonable cost of the tenant improvements for which Tenant has paid and after amortization of the reasonable Assignment costs, shall be divided and paid as follows: (a) so long as
after such Assignment, the original Tenant named herein shall occupy not less than seventy-five percent (75%) of the Rentable Area of the premises, twenty-five percent (25%) to Tenant and seventy-five percent (75%) to Landlord; and (b) in all other
cases, ten percent (10%) to Tenant and ninety percent (90%) to Landlord. 
  
 20.4    Fair Market Rent 
  
 In any subletting undertaken by Tenant, Tenant shall diligently seek to obtain not less than Fair Market Rent for the space so sublet. In any assignment of this Lease in whole or In part; Tenant shall seek to obtain
from the assignee consideration reflecting a value of not less than Fair Market Rent for the space subjected to such assignment. Tenant shall provide Landlord, upon Landlord’s demand, true and correct executed copies of the documents
constituting such Assignment and any amendments thereof during the Term. 
  
 20.5    No Release from Liability 
  
 No Assignment by Tenant shall relieve Tenant or any Guarantor of any obligation under this Lease or any Guaranty. Any Assignment that conflicts with the
provisions hereof shall be void. No consent by Landlord to any Assignment shall constitute a consent to any other Assignment nor shall it constitute a waiver of any of the provisions of this Section 20 as they apply to any such fixture sublettings
or assignments. 
  
 20.6    Compliance
with Laws 
  
 Any improvements, additions, or alterations
to the Development that are required by any law, ordinance, rule or regulation, or are deemed necessary or appropriate by Landlord as a result of any Assignment hereunder, shall be installed and provided by Tenant or the Assignee without cost or
expense to Landlord. 
  
 20.7    Reimbursement of Costs 
  
 Landlord may lire outside consultants to review all Assignment documents and information. Tenant shall reimburse Landlord for the reasonable cost thereof, including reasonable attorneys’ 
  

 23 

 
fees, immediately on demand, but in no event shall Tenant be obligated to pay to Landlord more than One Thousand Five Hundred Dollars ($1,500.00).

  
 20.8    Negotiation with Assignee

  
 Without liability to Tenant, Landlord shall have the
right to offer and to lease space in the Development; or in any other property, to any party, including without limitation parties with whom Tenant is negotiating, or with whom Tenant desires to negotiate, concerning assignment or subletting the
premises, or any portion thereof. 
  
 20.9    Change of Control; Affiliates. 
  
 “Assignment” within the meaning of this Section 20 includes any change in control of Tenant or any Guarantor, or any sale of more than half the assets of Tenant or any Guarantor outside the ordinary course
of business. Tenant shall notify Landlord of any such change in control or sale prior to its consummation, and concurrently shall submit current financial statements applicable thereto, all subject to Landlord’s reasonable consent and
Landlord’s other rights under this Section 20, as in the case of any other Assignment. 
  
 Notwithstanding the foregoing, Landlord agrees that Tenant may enter into an Assignment, without Landlord’s consent, with any entity which controls, is controlled by or is under common control with Tenant, or
with any entity resulting from a merger or consolidation with Tenant, or with any person or entity which acquires all the assets of Tenant as a going concern in the business that is being conducted on the Premises, provided that, before such
Assignment shall be effective, (a) the Assignee shall assume in writing, in full, the obligations of Tenant under this Lease, (b) any Guarantor shall explicitly agree in writing that any Guaranty shall remain in full force and effect notwithstanding
such Assignment and (c) Landlord shall be given written notice of such assignment and assumption. Any such Assignment shall not, in any way, affect or limit the liability of Tenant or any Guarantor under the terms of this Lease or any Guaranty, even
if after such Assignment the terms of this Lease are materially changed or altered without the consent of Tenant, the consent of whom shall not be necessary. As used in this Section 20.9, control (including, with correlative meanings, the terms
“controlled by” and “under common control with”) shall mean the possession, directly or indirectly, of the power to direct or cause the direction of management and policies, whether through the ownership of voting securities or
by contract or otherwise. 
  
 20.10    Conveyance by Landlord 
  
 Landlord may transfer, assign and convey all or any part of or interest in the Development or any of its rights under this Lease. If Landlord transfers, ass’s or conveys its rights under this Lease, it shall
thereby be released from any further obligations under this Lease, Landlord’s successors-in-interest shall be deemed to have assumed those obligations, and Tenant will attorn and look solely to Landlord’s successor-in-interest for
performance of those obligations. 
  

 24 

 21.    SUBORDINATION 
  
 This Lease and all rights of Tenant under this Lease are subject, and
subordinate to any of the following, and any modifications thereof; which may now or hereafter affect any portion of the Development: (a) any Mortgage, or any ground or underlying lease covering any part of the Development, provided that the
Mortgage holder or ground lessor shall agree that Tenant’s peaceable possession of the Premises will not be disturbed on account of such subordination so long as Tenant is not in default under this Lease and attorns to such Mortgage holder or
ground lessor, (b) any applicable laws, rules, statutes and ordinances of any governmental authority having jurisdiction, and (c) all utility easements and agreements. On sale by foreclosure of a Mortgage or sale at lieu of foreclosure, Tenant will
attorn to the purchaser if requested by such purchaser, and recognize the purchaser as the Landlord under this Lease. These provisions are self-operative and no further instrument is required to effect them; however, upon demand from time to time,
Tenant shall execute, acknowledge and deliver to Landlord any commercially reasonable instruments and certificates necessary or proper to evidence such subordination, and/or attornment or, if Landlord so elects, to render any of the foregoing
subordinate to this Lease or to any or all rights of Tenant hereunder. Tenant further waives duo provisions of any current or future statute, rule or law which may give or purport to give Tenant any right or election to terminate or otherwise
adversely affect this Lease and the obligations of Tenant hereunder in the event of any such foreclosure proceeding or sale, and, agrees that this Lease shall not be affected in any way whatsoever by any such proceeding or sale unless the Mortgagee,
or the purchaser, shall declare otherwise. 
  
 22.    ESTOPPEL CERTIFICATE 
  
 Promptly upon no less than ten (10) days after Landlord’s prior written request, Tenant will from time to time execute and deliver to Landlord a certificate, substantially in the form attached hereto as Exhibit
D, certifying. (i) the date of commencement of this Lease; (ii) the fact that this Lease is unmodified (except as the certificate specifies) and in full force and effect; (iii) the date to which the sums payable under this Lease have been paid; (iv)
that there are no current defaults under this Lease by either Landlord or Tenant except as specified; and (v) such other matters as Landlord requests. This certification may be relied upon by any actual or prospective Mortgagee or purchaser of all
or part of the Development or any interest therein or in Landlord. Failure to so execute and deliver said certificate will be conclusive upon Tenant (i) that this Lease is in full force and effect, without modification except as may be represented
by Landlord, (ii) that there are no uncured defaults in Landlord’s performance, and (iii) that no more than one (1) month’s rental has been paid in advance; and Tenant irrevocably authorizes Landlord, as Tenant’s attorney-in-fact and
in Tenant’s name, to so execute and deliver said certificate. Landlord shall deliver to Tenant, from time to time, upon no less than ten (10) days after Tenant’s prior written request, a certificate in a form similar to that described
herein and reasonably acceptable to Landlord. 
  

 25 

 23.    INTENTIONALLY DELETED 
  
 24.    SURRENDER OF
PREMISES 
  
 Upon expiration or earlier
termination of this Lease, Tenant will surrender the Premises to Landlord in as good repair and condition as when Tenant first occupied, except for reasonable wear and tear, and for damage or destruction by fire or other casualty or any condemnation
for which Tenant is not responsible or liable under this Lease. Tenant will concurrently deliver to Landlord all keys to the Premises, and restore any locks which it has changed to the system which existed at the commencement of the Term. If
possession is not immediately surrendered, Landlord may enter upon and take possession of the Premises and expel or remove Tenant and any other person who may be occupying the Premises or any part thereof. Tenant acknowledges that Landlord will be
attempting to lease the Premises with any such Lease to be effective upon expiration of the Term, and failure to surrender the Premises could cause Landlord to incur liability to such successor tenant for which Tenant shall be responsible hereunder
to the full extent thereof. 
  
 24.1    Leasehold Improvements and Fixtures 
  
 At the expiration or earlier termination of this Lease, Landlord may rewire the removal of any or all Alterations, above-Standard Tenant Improvements, personal property and equipment from the premises, and the
restoration of the Premises to its condition prior to installation of such items, except for reasonable wear and tear, and for damage or destruction by fire or other casualty or any condemnation for which Tenant is not responsible or liable under
this Lease, at Tenant’s sole cost and expense; provided that Landlord so notified Tenant in accordance with Section 10.2 of this Lease. Unless Landlord requires their removal pursuant to this Lease, all Alterations and above-Standard Tenant
Improvements made to the Premises shall remain upon and be surrendered with the Premises at the expiration or earlier termination of this Lease. All personal property and equipment on or about the Premises, other than that which is affixed to the
Premises so that it cannot be removed without material damage to the Premises or the Building, shall be removed from the Premises by Tenant at the expiration or earlier termination of this Lease. All removals by Tenant will be accomplished in a good
and workmanlike manner so as not to damage any portion of the Building, and Tenant will promptly repair and restore all damage done. If Tenant does not so remove any property which it has the right or duty to remove, Landlord may immediately either
claim it as abandoned property, or remove, store and dispose of it in any manner landlord may choose, at Tenant’s cost and without liability to Tenant or any other party. The provisions of this Section shall survive the expiration or earlier
termination of this Lease. 
  
 24.2    Holding Over 
  
 If Tenant does not surrender the Premises as required and holds over after its right to possession ends, Tenant shall become a tenant at sufferance only, at a monthly rental rate equal to one hundred fifty percent (150%) of the total Rent
payable in the last prior full month, without renewal, extension or expansion rights, and otherwise subject to the terms, covenants and conditions herein specified, so far as applicable. Nothing other than a fully executed written agreement of the
parties creates any other relationship. Tenant is liable for Landlord’s loss, costs and damage from 
  

 26 

 
such holding over, including, without. limitation, those from Landlord’s delay in delivering possession to other parties. These provisions are in
addition to other rights of Landlord hereunder and as provided by law. The provisions of this Section shall survive the expiration or earlier termination of this Lease. 
  
 25.    PROFESSIONAL FEES 
  
 Each party shall be entitled to reasonable attorneys’ fees and all other
costs and expenses incurred in the preparation and service of notice of default and consultations in connection therewith, whether or not a legal action is subsequently commenced in connection with such default. In any dispute between the parties
(whether or not litigated) arising hereunder or out of Tenant’s use or occupancy of the Premises, the prevailing party’s reasonable costs and expenses (including fees of attorneys and expenses) will be paid or reimbursed by the
unsuccessful party. As used herein, “prevailing party” shall mean the party who substantially prevails in the matter at issue, including without limitation, a party who dismisses an action for recovery hereunder in exchange for payment of
the sums allegedly due, performance of covenants allegedly breached of consideration substantially equal to the relief sought in the action. The provisions of this Section shall survive the expiration or earlier termination of this Lease.

  
 26.    GENERAL PROVISIONS

  
 26.1    Mortgage Protection

  
 Tenant shall not sue Landlord for damages or exercise
any right to terminate until (a) it gives written notice to any Mortgagee whose name and address have been furnished to Tenant, and (b) a reasonable time (but in no event more than thirty (30) days following receipt of such notice or such additional
time as is reasonably required) for such Mortgagee, at its option, to remedy the act or omission giving rise to such suit has elapsed following the giving of the notice, without the same being remedied. During that time, landlord shall not be
considered in default, and Landlord and/or any Mortgagee and/or their employees may enter the Premises in accordance with Section 12 and do therein whatever may be necessary to remedy the act or omission, it bang agreed that no Mortgagee shall have
any obligation to Tenant to cure or remedy any act or omission of Landlord. 
  
 26.2    Successors and Assigns 
  
 Subject to Section 20 hereof, this Lease shall inure to the benefit of and bind all parties hereto and their respective successors and assigns.

  
 26.3    Waiver 

 
 Tenant waives any right it may now or hereafter have (a) to redeem the
Premises or to have a continuance of this Lease after expiration or earlier termination of this Lease, (b) for exemption of property from liability for debt or for distress for rent, or (c) relating to notice or delay in levy of execution in case of
eviction for non-payment of rent. 
  

 27 

 26.4    Identification of Tenant 
  
 If there is more than one party constituting Tenant or any Guarantor, their
obligations are joint and several, and Landlord need not first proceed against any of them before proceeding against the others, nor shall any Guarantor be released for any reason whatsoever, including, without limitation, any amendment of this
Lease, any forbearance by Landlord or waiver of any of Landlord’s rights, the failure to give any party constituting Tenant or any Guarantor any notices, or the release of any party liable for the payment of Tenant’s obligations. If there
is more than one party constituting Tenant; any of them acts for all others in every regard with respect to this Lease (including but not limited to any renewal, extension, expiration, termination or modification). 
  
 26.5    Parking 
  
 Tenant shall be entitled to non-preferential and non-exclusive use of the
number of parking spaces in the Common Areas specified in the Lease Summary, for which right Tenant will pay the monthly fee per space that Landlord sets from time to time for each type of space, plus any tax or assessment imposed by any
governmental authority in connection with the parking privileges provided to Tenant pursuant to this Lease. Said monthly fees shall be paid whether or not Tenant uses said spaces; provided, however, that Landlord hereby waives its right to collect
such parking fees from Tenant for the spaces during the initial term of this Lease, except to the extent that Landlord is required to impose a parking fee by any governmental regulation now or hereafter applicable to any part or all of the
Development, or to Landlord or Tenant Landlord may assign any unreserved and unassigned parking spaces and/or make all or a portion of such spaces reserved, if it determines in its sole discretion that it is necessary for orderly and efficient
parking. Landlord at any time may substitute an equivalent number of parking spaces in a parking structure or subterranean parting facility or in a surface parking area within a reasonable distance of the Premises. 
  
 26.6    Interpretation of Lease 

 
 Tenant acquires no rights by implication from this Lease, and is not a
beneficiary of any past, current or future agreements between Landlord and third parties. Surrender or cancellation of this Lease shall not work a merger, and shall, at Landlord’s sole option, either terminate all existing subleases or
subtenancies or shall operate as an assignment to Landlord of all such subleases or subtenancies. The delivery of keys to Landlord or any Landlord Party is not a termination of this Lease or a surrender of the Premises. 
  
 Headings in this Lease are for convenience only, and do not affect the
meaning of the text. Unless the context indicates otherwise, words of any gender or grammatical number include all genders and numbers. Where the context conflicts with the definition of any term, the context will control, but only for that purpose
and related purposes. If any provision of this Lease or any application thereof is invalid, void or illegal, no other provision or application shall be affected. 
  
 California law governs this Lease. Neither party may record this Lease or a copy or memorandum thereof. Submission of this
Lease to Tenant is not an offer, and Tenant will have no 
  

 28 

 
rights hereunder until each party executes a counterpart and delivers it to the other party. As used herein, the word “including” shall be
construed to mean “including without limitation.” 
  
 26.7    Limitation on Liability 
  
 Landlord’s rights hereunder are solely for Landlord’s benefit, and Landlord has no duty to exercise them for the benefit of Tenant or others. Any liability of Landlord and the Landlord Parties to Tenant and
the Tenant Parties under this Lease, or arising from the relationship under it, is limited to the interest of Landlord in the Building, and no personal liability shall at any time be asserted or enforceable against Landlord or Landlord Parties on
account of Landlord’s or Landlord Parties’ obligations or actions under this Lease. If tenant proposes any action which requires Landlord’s consent and such consent is impermissibly withheld, denied or delayed; Tenant may only seek an
injunction or specific performance but shall not be entitled to damages therefor, including, without limitation, consequential or incidental damages or lost profits. 
  
 26.8    Traffic Impact 
  
 Traffic control and flow is a major concern of local government, of Landlord and of each tenant in the Building and
surrounding buildings. Tenant will cooperate with Landlord in reasonable efforts to alleviate the traffic impact or the Development on the local area streets and highways. 
  
 26.9    Financial Statements 
  
 Tenant represents, warrants and covenants that financial statements heretofore or hereafter furnished to Landlord, in
connection with this Lease, are accurate and are not materially misleading. At any time during the Term, Tenant shall, upon ten (10) days prior written notice, provide Landlord with a current financial statement and financial statements of the two
(2) years prior to the current financial statement year, and prepared in accordance with generally accepted accounting principles and, if such is Tenant’s normal practice, audited by an independent certified public accountant. 
  
 26.10    Quiet Enjoyment 
  
 If Tenant pays all sums and performs all its other obligations under this
Lease, Tenant shall and may peaceably and quietly have, hold and enjoy the Premises against all persons claiming any rights or interest in or to the Premises by or through landlord, subject to this Lease and to rights to which this Lease is
subordinate. Tenant acknowledges that the Building and the general area in which the Building is located is subject to sight, sound and overflight by general aviation aircraft. 
  
 26.11    Payments and Notice 
  
 Any notice or document shall be considered delivered whether actually received or not, on the third day after deposit in the
United States mail, postage prepaid, registered or certified mail, return receipt requested, addressed to the parties hereto at the respective addresses set forth on the Lease Summary or at such other address as the party to be notified may from
time to time designate by at least fifteen (15) days’ prior written notice delivered in accordance with this Section 26.11 to 
  

 29 

 
the notifying. parties, or when personally delivered to that address; except that if such day is not a business day, the notice or document will be
considered delivered on the next business day. All payments required to be made by Terrain to Landlord are to be paid, without prior demand except as may be expressly specified herein and without any setoff, deduction or counterclaim whatsoever,
except as may be expressly specified herein, in legal tender of the United states of America at the address set forth on the invoice or, if no invoice is submitted or no address is set forth at the address for the Landlord set forth on this Lease or
at any other address as Landlord may specify from time to time by written notice in accordance with this Section 26.11. Any amounts overdue from Landlord or Tenant hereunder shall accrue interest from the date due at the Prime Rate plus four percent
(4%) per annum, but in no event more than the legally permissible rate. If Tenant is tart in the payment of Base Rent and/or Additional Rent for two (2) consecutive months, Landlord may require Tenant to pay Base Rent and/or Additional Rent in
advance on a quarterly basis. If any check or other payment device is returned due to insufficient finds or any other reason, Landlord may require all fixture payments to be made by money order or cashier’s check. 
  
 26.12    Late Charge 
  
 If any amounts due hereunder from Tenant are not received by Landlord within
five (5) days after said amounts are due, Tenant shall also pay to Landlord a late charge of five percent (5%) of all such past due amounts, for which the parties agree is a fair and reasonable estimate of the extra costs (including, without
limitation, processing and accounting charges) Landlord will incur by reason of the laze payment Acceptance of any late charge shall not constitute a waiver of Tenant’s default with respect to such overdue amount, or prevent Landlord from
exercising any of its other rights and remedies. 
  
 26.13    Rules and Regulations 
  
 Tenant and the Tenant parties shall comply with the Rules and Regulations. 
  
 26.14    Rights Reserved by Landlord 
  
 In addition to other rights retained or reserved, Landlord reserves the following rights, exercisable without notice and
without liability to Tenant and without effecting an eviction, constructive or actual, or in any way diminishing Tenant’s obligations: (a) to change the name or street address of the Development or any part thereof; (b) to install, affix and
maintain, modify or remove any and all signs on the exterior and interior of the Building or any other part of the Development; (c) to designate and approve, prior to installation, all types of interior and exterior window treatments and to control
all internal lighting that may be visible from the exterior of the Building; (d) the exclusive right to designate, limit, restrict and control any business and any service in or to the Building or its tenants or to any other part of the Development;
(e) to keep, and to use in appropriate instances, keys to all doors within and into the premises (no locks shall be changed or added without the prior written consent of Landlord); (f) to decorate and make repairs, alterations, additions, changes or
improvements whether structural or otherwise (specifically including, without limitation, those in conjunction with Landlord’s construction of additional buildings) in and about any part of the Development and to enter the Premises In
accordance with Section 12 of this Lease 
  

 30 

 for these purposes and, during such work, to temporarily close doors, entryways, public space and corridors in the
Development to interrupt or temporarily suspend Building services and facilities and to change the arrangement and location of entrances or passageways, windows, doors and doorways, corridors, elevators, stairs, toilets, or other public parts of the
Development; (g) to approve the weight, size and location of safes and other heavy equipment and articles in and about the Premises and the Building, and to require all such items and furniture to be moved into and out of the Building and Premises
only at times and in such manner as Landlord directs (movement of Tenant’s property is entirely at the risk and responsibility of Tenant, and Landlord reserves the right to require permits before allowing any property to be moved into or out of
the Building); (h) to have access for Landlord and other tenants of the Building to any mail chutes located on the Premises according to the rules of the United States Postal Service; and (i) to take all reasonable measures Landlord considers
advisable for the security of the Development and its occupants. 
  
 26.15    Related Parties 
  
 Where either party agrees not to do a particular thing, it also agrees not to permit its Related Parties to do so. Where either party waives rights against the other party, it also waives the same rights against the other party’s
Related Parties. Thai waiver shall be considered a waiver on behalf of the party making it, of all that party’s Related Parties, and of anyone claiming under any of them, including insurers and creditors. 
  
 26.16    Landlord’s Costs 

 
 Where Tenant is required to pay or reimburse Landlord for the costs of any
item, the cost shall be the reasonable and customary charge established by Landlord from time to time, including a reasonable allocation of Landlord’s overhead, administrative and related costs associated with the ownership and operation of the
Development. Failure to pay any reimbursable cost shall be treated as a failure to pay Rent in connection with any request by Tenant for the consent of Landlord to an Alteration, Assignment or other act proposed by Tenant under this Lease, Tenant
shall pay Landlord’s reasonable costs and expenses incurred in connection therewith including, without limitation, attorneys’, architects’, engineers’ and other consultants’ fees. 
  
 26.17    Invoices 
  
 The parties hereto agree that each party will promptly notify the other party
of any dispute such party may have regarding any invoice from the other party. If either party does not so notify the other party within thirty (30) days after receiving any such invoice, such party shall be conclusively deemed to have agreed to
such invoice and all underlying facts. 
  
 26.18    Force Majeure; Time of Essence 
  
 When a period of time is herein prescribed for action to be taken by either party (excluding the payment of money by Tenant under this lease), such party shall not be liable or responsible for, and there is excluded
from the computation for any such period of time; any delays due to strikes, riots, acts of God, shortages of labor or materials, war, governmental laws, regulations or restrictions 
  

 31 

 or any other cause of any kind whatsoever which is beyond the control of such party. Subject to the preceding sentence,
time is of the essence of every part of this Lease. 
  
 26.19    Negotiated Transaction 
  
 The parties mutually acknowledge that thus Lease has been negotiated at arm’s length. The provisions of this Lease shall be deemed to have been drafted by all of the parties and this Lease shall not be
interpreted or construed against any party solely by virtue of the fad that such party or its counsel was responsible for its preparation. 
  
 26.20    Nondisturbance, Attornment and Subordination Agreement 
  
 Upon Landlord’s request, landlord, Tenant and Landlord’s Mortgagee
shall execute, acknowledge (notarize) and deliver a Non-Disturbance, Attornment and Subordination Agreement (the “Non-Disturbance Agreement”) substantially in the form attached to this Lease as Exhibit F. Tenant shall not record the
Non-Disturbance Agreement or a copy or memorandum thereof. 
  
 26.21    Nondiscrimination 
  
 Tenant herein covenants by and for himself or herself, his or her heirs, executors, administrators and assigns, and all persons claiming under or through him or hex, and this Lease is made and accepted upon and subject to the following
conditions: That there shall be no discrimination against; of segregation of, any person or group of persons on account of race, color creed, religion, sex, marital status, national origin or ancestry in the leasing, subleasing, transferring,
use’ occupancy, tenure or enjoyment of the Premises herein leased, nor shall Tenant, or arty person claiming under of through him or her, establish or permit any such practice or practices of discrimination or segregation with reference to the
selection, location, number, use or occupancy of tenants, lessees, subtenants, sublessees or vendees in the Premises herein leased. 
  
 26.22    Corporate Authority 
  
 If either party signs as a corporation, limited liability company, or partnership, each of the persons executing this Lease on behalf of such party does
hereby covenant and warrant that such party is a duly authorized and existing entity, that such party has and is qualified to do business in the State of California, that the entity has full right and authority to enter into this Lease, end that
each and both of the persons signing on behalf of the entity arc authorized to do so. 
  
 26.23    Notice Pursuant to California Health d Safety Code Section 25359.7 
  
 In 1981-82, the Development was the subject of a state-supervised cleanup of hazardous waste disposed of on the site by prior occupants. As part of the
cleanup approved by the applicable agencies, some soils containing heavy metals were left in place, covered by clean fill. These soils are managed in accordance with the requirements of the applicable agencies and a Declaration of Covenants,
Conditions and Restrictions imposed by Homart Development Co. 
  

 32 

 26.24    Entire Agreement; Amendments. 
  
 THIS LEASE CONTAINS ALL AGREEMENTS OF THE PARTIES CONCERNING THIS SUBJECT
MATTER, SUPERSEDING ANY SUCH PRIOR AGREEMENTS, REPRESENTATIONS OR WARRANTIES, AND MAY BE AMENDED OR MODIFIED ONLY BY A WRITTEN AGREEMENT SIGNED BY BOTH PARTIES. 
  

[The balance of this page is intentionally left blank] 
  

 33 

 THIS LEASE SHALL NOT BE
BINDING UPON OR ENFORCEABLE BY EITHER PARTY UNTIL FULLY EXECUTED BY
BOTH LANDLORD AND TENANT. 
  
 IN WITNESS WHEREOF, the parties have executed this Lease as of the date fast above written. 
  

	 LANDLORD
	 	 	 	 HMS OFFICE, L.P.,
 a Delaware
limited partnership

					
	 	 	 	 	 	 	By:	 	Hines Office Company, L.L.C.        
					
	 	 	 	 	 	 	Its:	 	General Partner
					
	 	 	 	 	 	 	By:	 	  /s/    TOM OWENS
	 	 	 	 	 	 	 	

				
	 	 	 	 	 	 	Name:    Tom Owens
				
	 	 	 	 	 	 	Title:      Manager
			
	 TENANT
	 	 	 	 ELAN PHARMACEUTICALS, INC.,
 a
Delaware corporation

					
	 	 	 	 	 	 	By:	 	  /s/    JOHN VARIAN
	 	 	 	 	 	 	 	

				
	 	 	 	 	 	 	Name:    John Varian
				
	 	 	 	 	 	 	 Title:      Sr. Vice President,
                Finance & Administration

					
	 	 	 	 	 	 	By:	 	  /s/    DONALD R. JOSEPH
	 	 	 	 	 	 	 	

				
	 	 	 	 	 	 	Name:    Donald R. Joseph
				
	 	 	 	 	 	 	 Title:      Vice President
                Commercial & Legal Affairs

  
  
  
  

 34 

 EXHIBIT A 
  
 THE GATEWAY 
  
 FLOOR PLAN 
  
 [2 Graphics] 
  

 A-1 

 EXHIBIT A-1 
  
 THE GATEWAY 
  
 LEGAL DESCRIPTION 
  
 Beginning At A Point On Gateway Boulevard Common To Lots 1 And 4 As Said Boulevard And Lots Are Shown On Said Map; Thence Along The Line
Common To Said Lots The Following Courses And Distances; N 51 17’1 9” W 50.00 Feet; Thence On A Curve To The Right Having A Radius Of 200.00 Feet Through A Central Angle Of 53 02’26” An Arc Distance Of 185.15 Feet; Thence On A
Curve To The Left Having A Radius Of 200.00 Feet Through A Central Angle Of 53 02’26” An Arc Distance Of 185.15 Feet; Thence N 51 17119” W 22738 Feet To The Southeasterly Line Of Industrial Way As Shown On Said Map; Thence Along Said
Southeasterly Line N 38 42’41” E 1208.04 Feet; Thence Continuing Along Said Southeasterly Line N.38 42’27” E 6550 Feet To The Western Corner Of Lot 9 As Shown On Said Map; Thence Along The Line Common To Said Lots 1 And 9 S 51
17’19” E 930.00 Feet To The Northwesterly Lime Of Said Gateway Boulevard; Thence Along Said Line Of Gateway Boulevard The Following Courses And Distances; 
  
 S 38 42’41” W 79.14 Feet; 
 Thence S
63 42’41” W 592 Feet; 
 Thence S 38 42’41” W 100.00 Feet; 
 Thence S 13 42’41” W 5.92 Feet; 
 Thence S 38 42’41” W 148.64 Feet; 
 Thence Along A Curve To The Right Having A Radius Of 703.00 Feet through A Central Angle Of 27 22’20” An Arc Distance 335.85 Feet; 
 Thence S 66 05’01” W 359.00 Feet; 
 Thence Along A Curve To The Left
Having A Radius Of 797.00 Feet Through A Central Angle Of 27 22’20” 
 An Arc Distance Of 380.76 Feet; Thence S 38 42’41” W 55.00 Feet To
The Point Of Beginning Of This Description. 
 Containing A 24.160 Acres, More Or Less. 
  

 A-1-1 

 EXHIBIT B 
  
 SAMPLE FORM OF 
  
 LEASE COMMENCEMENT CERTIFICATE 
  
 OFFICE BUILDING 
  
 Re: The Gateway 
 651 Gateway Boulevard, Suite
950 and Suite 980 
 So. San Francisco, CA 94080 
  
 This is to certify that Elan Pharmaceuticals, Inc., a Delaware corporation, Suite 950 and Suite 980, has opened/closed on [Date] . 
  

	BILLING
ADDRESS                                       
                         	 	Rentable
Area                                       
                                     
	 	 	Lease Commencement
	NAME                                      
                                        
              	 	Date
	ADDRESS                                     
                                        
       	 	Lease Expiration Date
	CITY, STATE,
ZIP                                       
                             	 	Rental Payment Commencement Date
	 	 	Date
	ATTN:                                     
                                        
               	 	Final Tenant Construction
	ATTN:                                     
                                        
               	 	Overage
	 	 	Payment due from Tenant
	 	 	Insurance Certificate
	 	 	submitted (Y/N)
	 	 	Security Deposit received
	By:                                      
                                        
                     	 	By:                                      
                                        
                   
	Agent for Elan Pharmaceuticals, Inc.	 	Agent for HMS OFFICE, L.P.

  
  

 B-1 

 EXHIBIT C 
  
 THE GATEWAY 
  
 STANDARDS FOR UTILITIES AND SERVICES

  
 1. Elevators. Provide non-attended passenger
elevators to and from the floor(s) on which the Premises are located. Landlord may limit the number of elevators operating outside normal business hours. 
  
 2. HVAC. On Monday through Friday, except holidays, from 7:00 a.m. to 6:00 p.m., ventilate the Premises and furnish air conditioning or heating on
such days and hours, in temperatures and amounts which in Landlord’s good faith judgment are reasonably required for comfortable occupancy of the Premises under normal business operations. If Tenant requires air conditioning during other hours,
Landlord will furnish same through an access system provided to Tenant at the Premises, if available, or otherwise as specified in a written request of Tenant delivered to the Building management office before noon on the preceding business day. For
this service Tenant will pay Landlord, upon receipt of Landlord’s statement, the charge at an hourly rate determined by Landlord from time to time, which is currently $30.00 per hour. Tenant agrees that neither Tenant nor any Tenant Party shall
at any time enter mechanical installations or facilities of the Building or adjust, tamper with, touch or otherwise in any manner affect said installations or facilities. The cost of maintenance and service calls to adjust and regulate the air
conditioning system shall be charged to Tenant if the need for maintenance work results from either Tenant’s adjustment of room thermostats or Tenant’s failure to comply with Landlord’s rules governing the temperature within the
Premises. 
  
 3. Lighting. Furnish electric lighting for
all public areas and special service areas of the Building as Landlord determines in good faith to be reasonable and standard, including replacement of Building standard lights, bulbs and tubes. 
  
 4. Electrical Service. Subject to the limitation of this Paragraph 4,
furnish electrical service to the Premises, including providing and installing all Building standard replacement lighting tubes. If Tenant uses more electrical power than Landlord in good faith considers reasonable or normal for office use, Tenant
will pay Landlord on a monthly basis the cost of such excess power consumed by Tenant. Consumption will be determined, at Landlord’s election, either (a) by a survey performed by a reputable consultant selected by Landlord, or (b) through
separate meters or submeters installed, maintained and read by Landlord at Tenant’s cost. For purposes of this Paragraph 4 only, “month” and “monthly” shall mean any billing period used by the utility or other power provider
supplying electricity. All installations of electrical fixtures, appliances and equipment within the Premises shall be subject to Landlord’s prior approval, and if they affect the temperature or humidity otherwise maintained, Landlord may, at
Tenant’s sole cost and expense (to be paid within (30) days after delivery of written demand supported by invoices or other reasonably satisfactory evidence), install supplemental air conditioning units. Tenant’s use of electricity shall
never exceed Tenant’s share of the capacity of existing feeders to the Binding or of the risers, wiring 
  

 C-1 

 installations and transformers serving tire floor(s) containing the Premises. Landlord shall provide up to 3.5 watts per
usable square foot (demand) of riser and floor panel electrical capacity averaged over the floor being serviced. Tenant shall be allocated an approximate 2.0 watts per usable square foot for power and 1.5 watts per usable square foot for lighting.
Any risers or wiring necessary to meet Tenant’s excess electrical requirements will be installed by Landlord on Tenant’s request, at Tenant’s sole cost and expense (to be paid in advance), but only if in Landlord’s good faith
belief they are necessary, and will not cause damage to the Building or a dangerous condition, entail excessive or unreasonable alterations, repairs or expense, or disturb other occupants. 
  
 5. Water. Provide toilet facilities, water for lavatory and toilet
purposes, cold water for drinking and tepid water for lavatory purposes, all at points of supply provided for general use of tenants in the Building through fixtures installed by Landlord or by Tenant with Landlord’s consent. 
  
 6. Janitorial. Provide janitorial service to the Premises on business
days and other cleaning services as Landlord determines to be reasonably required. Tenant will pay Landlord the full cost attributable to any extraordinary janitorial or cleaning services which the Premises may require. 
  
 7. Maintenance of Non-Building Standard Items. Maintenance and service
costs necessary for non-building standard items in the Premises shall be the responsibility of Tenant. As used in this paragraph, non-building standard items shall include, without limitation, heat pumps, condenser pumps, sinks and associated drain
pipes, faucets, hot water heaters, garbage disposals, dishwashers, refrigerators, ice makers, air conditioning units, projection scans and associated wiring and switching, incandescent downlight or wallwash fixtures and lamps, floor electrical
outlets and power poles. 
  
 8. Security Services. Provide
Building security personnel twenty-four (24) hours per day, seven (7) days per week, fifty-two (52) weeks per year and a card access system which allows access to individual office floors twenty-four (24) hours per day, seven (7) days per week,
fifty-two (52) weeks per year, all of which shall be provided by Landlord in its sole and absolute discretion. Notwithstanding Landlord’s prevailing security, Tenant waives any claim against Landlord with respect to any loss by theft or any
other damage suffered or incurred by Tenant in connection with any entry into the Premises or any other breach of security with respect to the Premises or the Building, except due to the gross negligence or willful misconduct of Landlord.

  
 Landlord reserves the right to adopt reasonably,
nondiscriminatory modifications and additions to these standards, which Landlord shall promptly deliver to Tenant in writing. 
  

 C-2 

 EXHIBIT D 
  
 SAMPLE FORM OF 
 TENANT ESTOPPEL CERTIFICATE 
  
 Elan
Pharmaceuticals, Inc., a Delaware corporation (“Tenant”) hereby certifies to                      as follows: 
  
 1. Attached hereto is a true, correct and complete copy of a lease dated,
                     1999, between Landlord and Tenant (the “Lease”), which demised premises located at 651 Gateway Boulevard, Suite
950 and Suite 980, South San Francisco, California 94080 (“Property’). The Lease is now in full force and effect and has been amended, modified, supplemented, extended, renewed or assigned by and only by the following described agreements,
copies of which are attached hereto (if none, so indicate), all of which (together with the Lease) are hereby ratified: 
  
                                       
                                        
                          
  
                                       
                                        
                          
  
 2. The term of this Lease commenced on
                    , 1999 and will expire on
                    , 200  . 
  
 3. Tenant has accepted and is now in possession of said premises. 
  

4. Tenant and Landlord acknowledge [that the Lease will be assigned to
                     and] that no modification, adjustment, revision or cancellation of the Lease or amendments thereto shall be effective
unless written consent of                      is obtained, and that until further notice, payments under the Lease may continue as
heretofore. 
  
 5. The amount of fixed monthly rent is
$             Tenant is paying in full lease rental which has been paid in full as of the date herein. No rent under the Lease has been paid for more than thirty (30) days in advance
of its due date. 
  
 6. The amount of security deposit held by
Landlord (if any) is $            . No other security deposits have been made. 
  
 7. All work required to be performed by Landlord or Tenant under the Lease has been performed, except for the following (if none, so indicate)
            . 
  
 8. There are no defaults on the part of the Landlord or Tenant under the Lease, except for the following (if none, so indicate)             .

  
 9. Tenant has no defense as to its obligations under the Lease
and claims no setoff or counterclaim against Landlord, except for the following (if none, so indicate)             . 
  

 D-1 

 10. Tenant has no right to any concession (rental or otherwise) or similar compensation in connection
with renting the space it occupies except as provided in the Lease, except for the following (if none, so indicate)             . 
  
 The foregoing certification is made with the knowledge that
                     is about to (fund a loan to) (purchase the property from) Landlord and that said party is relying upon the
representations herein made in (funding such loan) (making such purchase) 
  
 Dated:                     , 19    . 
  

	 TENANT:     Elan Pharmaceuticals, Inc.,
a Delaware corporation

	
	 By:                                      
                                        
                  

	
	 Name:                                     
                                        
             

	
	 Title:                                     
                                        
               

	
	 By:                                      
                                        
                  

	
	 Name:                                     
                                        
             

	
	 Title:                                     
                                        
               

  
  

 D-2 

 EXHIBIT E 
  
 THE GATEWAY 
  
 RULES AND REGULATIONS 
  
 1.    Signs.    Except as
specifically provided in this Lease to which these rules and regulations are attached, no sign, placard, picture, advertisement, name or notice shall be installed or displayed on any part of the outside or inside of the Building or on the Common
Areas or other areas of the Development without Landlord’s prior written consent. Landlord may remove, at Tenant’s expense and without notice, any sign installed or displayed in violation of this rule. All signs or lettering on doors and
walls must be approved by Landlord, and shall be printed, painted, affixed or inscribed or modified at Tenant’s expense by a person approved by Landlord. Without Landlord’s written consent, Tenant shall not use the name of the Building or
the Development in connection with or in promoting or advertising the business of Tenant except as Tenant’s address. Landlord and Tenant acknowledge that the existing signage on the monument located on the Development next to the Building is to
be removed and, subject to the provisions of this Lease, Tenant shall have the right to place signage on the monument, at its sole expense, until such time that the monument is removed. Landlord hereby agrees to provide Tenant with the
Building’s standard graphics at the entrance to the Premises and in the elevator lobby. 
  
 2.    Window Treatments.    Tenant shall not place anything against or near glass partitions or doors or windows which may appear unsightly from outside the Premises.
Tenant shall be held responsible for any damage to the glass coating within the Premises. If Landlord objects in writing to any curtains, blinds, shades, screens or hanging plants or other similar objects attached to or used in connection with any
window or door of the Premises, or placed on any windowsill, which are visible from the exterior of the Premises, Tenant shall immediately discontinue such use. 
  

3.    Common Areas.    The sidewalks, entrances, halls, corridors, elevators and stairways of the
Building and the Development shall not be obstructed or used as a waiting or lounging place by Tenant and the Tenant’s Parties. All entrance doors leading from the Premises to the hallways are to be kept closed at all time. The outside areas
immediately adjoining the Premises shall be kept clear at all times by Tenant, and Tenant shall not place or permit any obstructions, garbage, refuse, merchandise or displays in such areas. The halls, passages, exits, entrances, elevators,
escalators and stairways are not open to the general public, but are open, subject to reasonable regulations, to Tenant’s Parties. Landlord shall, in all cases, retain the right to control and prevent access thereto of all persons whose
presence in the judgment of Landlord would be prejudicial to the safety of the Development or any part thereof provided that nothing heroin contained shall be construed to prevent such access to persons with whom any tenant normally deals in the
ordinary course of its business, unless such persons are engaged in illegal or unlawful activities. Neither Tenant nor any Tenant Parties shall go upon the roof of the Building. 
  

 E-1 

 4.    Directory.    The directory of the Building will be
provided for the display of the name and location of tenants, and Landlord reserves the right to exclude any other names therefrom. Tenant shall be allocated its pro rata share of lines on the Building directory board in the main lobby. 

 
 5.    Cleanliness.    Tenant shall not exhibit carelessness or indifference to the good order and cleanliness of the Premises. 
  
 6.    Keys.    Landlord will furnish Tenant, free of charge, with two keys to
each exterior door lock in the Premises. All duplicate keys shall be purchased only from Landlord. Landlord may charge a reasonable fee for any additional keys. Tenant shall not make or have made additional keys, and Tenant shall not alter any lock
or install a new additional lock or bolt on any door of its Premises. Tenant, upon the termination of its tenancy, shall deliver to Landlord the keys to all doors and pay Landlord for any lost keys. 
  
 7.    Security Devices.    If
Tenant requires telephonic, burglar alarm or similar services, it shall first obtain and comply with Landlord’s instructions for their installation. 
  
 8.    Freight Elevators.    The Building service elevator shall be available for use by all tenants in the
Building, subject to such reasonable scheduling by Landlord. No equipment, materials, furniture, packages, supplies, merchandise or other property will be received in the Building or carried in the elevators except between such hours and in such
elevators as may be designated by Landlord. Tenant’s initial move-in and subsequent deliveries of bulky items, such as furniture, safes and similar items shall be made after obtaining Landlord’s written consent and shall be made during the
hours of 12:00 a.m. to 5:00 a.m. and 6:00 p.m. to 11:59 p.m., Monday through Friday, or at any time on Saturday or Sunday, unless otherwise agreed in writing by Landlord. Deliveries during normal office hours shall be limited to normal office
supplies and other small items. No deliveries shall be made which impede or interfere with other tenants or the operation of the Building. 
  
 9.    Floor Load.    Tenant shall not place a load upon any floor of the Premises which exceeds the load
per square foot which such floor was designed to carry and which is allowed by law. Prior to delivery of any heavy object to the Building, Tenant shall notify Landlord of such object’s specifications and contemplated location in order that
Landlord may take action to prevent structural load damage to the Building. Landlord shall have the right to prescribe the weight, size and position of all equipment, materials, furniture or other property brought into the Building. Heavy objects
shall, if considered necessary by Landlord, stand on such platforms as determined by Landlord to be necessary to properly distribute the weight, which platforms shall be provided at Tenant’s sole cost and expense. Tenant shall be responsible
for all structural engineering required to determine structural load. Business machines and mechanical equipment belonging to Tenant which cause noise or vibration that may be transmitted to the structure of the Building or to any space therein to
such degree as to be objectionable to Landlord or to any tenants in the Building, shall be placed and maintained by Tenant, at Tenant’s sole cost and expense, on vibration eliminators or other devices sufficient to eliminate noise or vibration.
The persons employed to move such equipment in or out of the Building must be acceptable to Landlord. Landlord will not be responsible for loss of, or damage to, any such equipment or other property from any cause, and all 
  

 E-2 

 
damage done to the Building by maintaining or moving such equipment or other property shall be repaired at the expense of Tenant. 
  
 10.    No Waste.    Tenant
shall not use any method of heating and air conditioning other than that supplied by Landlord. Further, Tenant shall not waste electricity, water or air conditioning and agrees to cooperate fully with Landlord to assure the most effective operation
of the Building’s heating and air conditioning and to comply with any governmental energy-saving rules, laws or regulations of which Tenant has actual notice. Tenant shall keep corridor doors closed, and shall close window coverings at the end
of each business day. 
  
 11.    Building
Identification.    Landlord reserves the right, exercisable without notice and without liability to Tenant, to change the name and address of the Building and/or any other part of the Development. 
  
 12.    Building
Access.    Landlord reserves the right to exclude from the Building between the hours of 12:00 am. to 7:00 a.m. and 6:00 p.m. to 11:59 p.m., Monday through Friday, and on Saturday, Sunday and holidays, any person not having a
Building issue key and is not identified on the daily access list. Tenant shall be responsible for all persons for whom it requests passes and shall be liable to Landlord for all acts of such persons. Landlord may prevent access to the Development
or any part thereof in case of invasion, mob, riot, public excitement or other commotion. Landlord may exclude or expel from the Development or any part thereof any person who, in Landlord’s judgment, is intoxicated or under the influence of
liquor or drugs or is in violation of any of the rules and regulations of the Development. Landlord shall not be liable for damages for any error with regard to the admission to or exclusion from the Development or any part thereof of any person.

  
 13.    Building
Security.    Before Tenant and the Tenant Parties leave the Premises each day, Tenant shall (a) close and lock the doors of its Premises, (b) shut off all water faucets and other utilities, (c) draw or lower window coverings,
and (d) turn out all lights. Tenant shall be responsible for any, damage or injuries sustained by other tenants or occupants of the Building or by Landlord for noncompliance with this rule. 
  
 14.    Outside
Services.    Tenant shall not obtain for use on the Premises, drinking water, food, beverage, towel or other similar services or accept barbering or bootblacking service upon the Premises, except as such hours and under such
regulations as may be fixed by Landlord. Canvassing, soliciting and distribution of handbills or any other written material, and peddling in the Building are prohibited, and tenant shall cooperate to prevent such activities. 
  
 15.    Lavatories.    The
toilet rooms, toilets, urinals, wash bowls and other apparatus shall not be used for any purpose other than that for which they were constructed and no foreign substance of any kind whatsoever shall be thrown therein. The expense of any breakage,
stoppage or damage resulting from the violation of this rule shall be borne by the tenant who, or whose Tenant parties, shall have caused it. 
  

 E-3 

 16.    Solicitation.    Tenant shall not snake any
room-to-room solicitation of business from other tenants in the Development or any part thereof. 
  
 17.    Electronic Devices.    Tenant shall not install any radio or television antenna, loudspeaker or
other devices on the roof or exterior walls of the Building. Tenant shall not interfere with radio or television broadcasting or reception from or in the Building or elsewhere. 
  
 18.    Trash Disposal.    Tenant shall store all its trash and garbage within
the Premises or in other facilities provided by Landlord. Tenant shall not place in any trash box or receptacle any material which cannot be disposed of in the ordinary and customary manner of trash and garbage disposal. All garbage and refuse
disposal shall be made in accordance with directions issued from time to time by Landlord. 
  
 19.    Prohibited Uses.    The Premises shall not be used for (a) the keeping of any bicycles, motorcycles or animals of any kind, or (b) lodging, or (c) for
manufacturing of any kind; nor shall the Premises be used for any illegal purpose. No cooling or heating of food is permitted on the Premises, excepting therefrom microwave ovens and equipment for brewing coffee, tea, hot chocolate and similar
beverages. Such cooking and heating devices and their use should be approved by Underwriters Laboratories in accordance with all applicable insurance regulations and federal, state, county and city laws, codes, ordinances, rules and regulations.
Tenant shall not install, maintain or operate upon the Premises any vending machines without the written, consent of Landlord, which consent shall not be unreasonably withheld. 
  
 20.    Prohibited Equipment.    Tenant shall not use in any space or in the
public halls of the Development any hand truck except those equipped with rubber tires and side guards or such other material handling equipment as Landlord may approve. Tenant shall not bring any other vehicles of any kind into the Building.

  
 21.    Safety
Procedures.    Tenant shall comply with all safety, fire protection and evacuation procedures end regulations established by Landlord or any governmental agency. 
  
 22.    Premises Security.    Tenant accepts full responsibility for
protecting its space from theft, robbery and pilferage, which includes keeping doors locked and other means of entry to the Premises closed and secure. Landlord shall not in any way be responsible to Tenants or any Tenant Party, for any loss of
property from the Premises or public areas or for any damage to any property thereon from any cause whatsoever. 
  
 23.    Building Management.    Tenant’s requirements will be attended to only upon appropriate
application to the Building management office by an authorized individual. Employees of Landlord shall not perform any work or do anything outside of their regular duties unless under special instructions from Landlord, and no employee of Landlord
will admit any person (Tenant or otherwise) to any office without specific instructions from Landlord. 
  
 24.    Waiver.    Landlord may waive any one or more of these Rules and Regulations for the benefit of
Tenant or any other tenant, but no such waiver by Landlord shall be construed as a waiver 

  

 E-4 

 
of such Rules and Regulations in favor of Tenant or any other tenant, nor prevent Landlord from thereafter enforcing any such Rules and Regulations against
any or all of the tenants of the Building. 
  
 25.    Integration.    These Rules and Regulations are in addition to, and shall not be construed to in any way modify or amend, in whole or in part, the terms, covenants, agreements and
conditions of the Lease. 
  
 26.    Additional Regulations.    Landlord reserves the right to make such other and reasonable rules and regulations as, in its judgment, may from time to time be needed for safety and
security, for care and cleanliness of the Development of any part thereof and for the preservation of good order therein. Tenant agrees to abide by all such Rules and Regulations hereinabove stated and any additional rules and regulations which are
adopted and delivered to Tenant in writing. 
  
 27.    Observance of Rules.    Tenant shall be responsible for the observance of all of the foregoing rules by Tenant’s employees, agents, clients, customers, invitees, licensees and
guests. 
  
 28.    Parking
Facilities.    The following rules and regulations shall govern use of the parking facilities within the Common Areas appertenant to the Development (such parking facilities being collectively referred to hereinafter as the
“Parking Area”). 
  
 28.1    Persons
using the Parking Area shall obey all signs and shall park only in areas designated for vehicle parking within painted stall lines. Tenant’s parking spaces shall be used only for parking vehicles no longer than full-sized passenger automobiles.
Tenant shall not permit any vehicle that belongs to or is controlled by Tenant, its agents, employees, invitees, licensees and visitors, to be loaded, unloaded or parked in areas other than those designated by Landlord or its parking operator for
such activities. No maintenance, washing, waxing or cleaning of vehicles shall be permitted in the Parking Area. Unless otherwise instructed, each person using the Parking Area shall park and lock his or her own vehicle. Neither Landlord nor its
parking operator shall be liable for damage to any vehicle, injury to any person or loss of any property, all of which risks are assumed by the person using the Parking Area. Parking pursuant to this Lease is intended as a license only, and no
bailment is intended or created hereby. Tenant shall abide by those rules promulgated by Landlord which provide for tandem parking. No overnight or extended term storage of any vehicles or other object shall be permitted. 
  
 28.2    Persons using the Parking Area shall comply with
any parking identification system established by Landlord or its parking operator. Such a system may include the validation of visitor parking, at the validation rate applicable to visitor parking from time to time as set by Landlord or its parking
operator. Parking stickers or other identification devices supplied by Landlord shall remain the property of Landlord. Such devices shall not be transferable, and any such device in the possession of an unauthorized holder may be retained by
Landlord and declared void. Upon the loss or obliteration of a parking identification device, Tenant shall pay such reasonable replacement charge as may be established by Landlord or its parking operator. Upon the termination of parking privileges,
all parking identification devices supplied by Landlord shall be returned to Landlord. Landlord may refuse the sale of monthly stickers or other parking identification devices to any tenant or person and/or his agents or representatives who
willfully refuse to comply with these 
  

 E-5 

 
Rules and Regulations and all unposted city, state or federal ordinances, laws, or agreements. Loss or theft of parking identification devices from
automobiles must be reported to the garage manager immediately, and a lost or stolen report must be filed by the customer at that time. Landlord may exclude any car from the parking facilities that does not have a identification device. Any packing
identification devices reported lost or stolen found on any unauthorized car will be confiscated and the illegal holder will be subject to prosecution. Lost or stolen devices found by the purchaser must be reported to the parking facility office
immediately to avoid confusion. 
  
 28.3    The speed limit within all parking areas shall be five (5) miles per hour. 
  
 28.4    Landlord reserves the right to modify, redesign or designate uses permitted in the Parking Area or any portion thereof to
relocate parking spaces from floor to floor, from one portion of the Parking Area to another or to reasonably adjacent offsite locations, and to allocate parking spaces between compact and standard sizes from time to time, as long as the same comply
with applicable laws and ordinances. Reserved parking spaces shall be clearly and prominently marked as such by Landlord. But neither Landlord nor its parking operator shall be liable or responsible for the failure of persons to observe such
markings or to obey other rules and regulations, agreements, laws or ordinances applicable to the Parking Area. Without limiting the generality of the foregoing, Landlord shall not be obligated to tow any violator’s vehicles or to declare a
default under or terminate the lease of any other tenant of the Building, on account of any such failure. If for any reason Landlord is unable to provide to Tenant all or any portion of its parking spaces or Tenant is unreasonably denied access
thereto during the initial term of this Lease or any renewal or extension hereof, such fact shall not be a default by Landlord or permit Tenant to terminate this Lease, either in whole or in part, but Tenant’s obligation to pay rental for any
parking space which is not provided by landlord shall be abated for so long as Tenant does not have the use of such parking space, in foil settlement of all claims that Tenant might otherwise have against Landlord by reason of Landlord’s
failure or inability to provide Tenant with such parking space. 
  
 Tenant shall be responsible for the compliance with all of the foregoing rules and regulations by Tenant and Tenant Parties. Landlord may refuse to permit any person who violates any such rules and regulations to have access to the
Development or any part thereof. Landlord reserves the right from tines to time to modify the rules and regulations set forth herein, including, without limitation, to adopt and modify such rules said regulations applicable to the Parking Area, as
it deems necessary for the proper operation. 
  

 E-6 

 EXHIBIT F 
  
 NON-DISTURBANCE, ATTORNMENT 
 AND SUBORDINATION AGREEMENT 
  
 This Agreement is made and entered into as of the      day of
                    ,          by and among BankBoston, N.A., as Agent for the Lenders (hereinafter called
the “Lender” having a mailing address at 100 Federal Street, Boston, Massachusetts 02106, ELAN PHARMACEUTICALS, INC., a Delaware corporation (hereinafter called the “Tenant”), having a mailing address of 800 Gateway Boulevard,
South San Francisco, CA 94080, Attn: General Counsel, and HMS OFFICE, L.P., a Delaware limited partnership, having a mailing address c/o Hines Office Company, LLC, 2800 Post Oak Boulevard, 50th Floor, Houston, Texas 77056 (hereinafter called the
“Landlord”). 
  
 Witnesseth: 
  
 WHEREAS, Landlord is the owner of certain real property located in South San
Francisco, California, and moue particularly described in Exhibit A attached hereto and made a part hereof (said property being hereinafter called the “Property”); and 
  
 WHEREAS, Landlord and Tenant made and entered into that certain Office Building Lease,
             dated with respect to certain premises constituting a portion of the Property therein described, known as 651 Gateway Boulevard, Suite 950 and Suite 980, South San Francisco,
California 94080 (said Leases as amended by the amendments described above, being hereinafter called tire “Lease” and said premises being hereinafter called the “Leased Premises”); and 
  
 WHEREAS, on or about the date hereof, Landlord has entered into and delivered
that certain Deed of Trust and Security Agreement/Mortgage in favor of Lender to be recorded in the                      (the “Official
Records”) prior to the recording of this Agreement (said Deed of Trust and Security Agreement/Mortgage being hereinafter called the “Security Deed”), conveying the Property to secure the payment of the indebtedness described in the
Security Deed; and 
  
 WHEREAS, on or about the date thereof;
Landlord has entered into and delivered that certain Collateral Assignment of Leases and Rents in favor of Lender to be recorded in the Official Records prior to the recording of this Agreement (said Collateral Assignment of Leases and Rents being
hereinafter called the “Assignment of Leases”), assigning all of Landlord’s right, title and interest as lessor under the Lease to further secure the indebtedness described in the Security Deed; and 
  
 WHEREAS, the parties hereto desire to enter into this Non-Disturbance,
Attornment and Subordination Agreement; 
  
 NOW, THEREFORE, for
and in consideration of the mutual covenants hereinafter set forth and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Lender, Tenant and Landlord hereby covenant and agree as follows: 

 

 F-1 

 1. ESTOPPEL 
  
 Tenant hereby certifies to Lender that (i) the Lease, as described above, is the true, correct and complete lease of the
Leased Premises, and has not been modified or amended and constitutes the entire agreement between Landlord and Tenant with respect to the Leased Premises, and (ii) as far as is known to Tenant, there are no defaults of Landlord under the Lease and
there are no existing circumstances which with the passage of time, or giving of notice, or both, would give rise to a default under the Lease and/or allow Tenant to terminate the Lease. 
  
 2. NON-DISTURBANCE 
  
 So long as no default under the Lease exists, nor any event has occurred which has continued to exist for such period of
time (after notice, if any, required by the Lease) as would entitle the lessor under the Lease to terminate the Tease or would cause, without any further action on the part of such lessor, the termination of the Lease or would entitle such lessor to
dispossess the lessee thereunder, the Lease shall not be terminated, nor shall such lessee’s use, possession or enjoyment of the Leased Premises or rights under the Lease be interfered with in any foreclosure or other action or proceeding in
the nature of foreclosure instituted under or in connection with the Security Deed or in case Lender takes possession of the property pursuant to any provisions of the Security Deed or the Assignment of Leases, unless the lessor under the Lease
would have had such right if the Security Deed or the Assignment of Leases had not been made, except that neither the person or entity acquiring the interest of the lessor under the Lease as a result of any such action or proceeding or deed in lieu
of any such action or proceeding (hereinafter called the “Purchaser”) nor Lender if Lender takes possession of or title to the Property shall be (a) liable for any act or omission of any prior lessor under the Lease; or (b) liable for the
return of any security deposit which lessee under the Lease has paid to any prior lessor under the Lease; or (c) subject to any offsets or defenses which the lessee under the Lease might have against any prior lessor under the Lease; or (d) bound by
any base rent, percentage rent or any other payments which the lessee under the Lease might have paid for more than the current month to any prior lessor under the Lease; or (e) bound by any amendment or modification of the Lease made without
Lender’s prior written consent; or (f) bound by any consent by any lessor under the Lease to any assignment or sublease of the lessee’s interest in the Lease made without also obtaining Lender’s prior written consent; or (g)
personally liable for any default under the Lease or any covenant or obligation on its part to be performed thereunder as lessor, it being acknowledged that Tenant’s sole remedy in the event of such defaults shall be to proceed against
Purchaser’s or Lender’s interest in the Property. Notwithstanding anything contained herein to the contrary, Lender shall have absolutely no obligation to perform any of Landlord’s construction covenants under the Lease, provided that
if Lender shall not perform such covenants in the event of foreclosure or deed in lieu thereof and within a reasonable time following taking of possession by Lender, then Tenant shall have the right to terminate its obligations under the Lease and
to pursue any and all legal remedies it may have against Landlord and any third parties other than Lender. 
  

 F-2 

 3. ATTORNMENT 
  
 Unless the Lease is terminated in accordance wide Paragraph 2, if the interests of the lessor under the Lease shall be
transferred by reason of the exercise of the power of sale contained in the Security Deed (if applicable) or by any foreclosure or other proceeding for enforcement of the Security Deed, or by deed in lieu of foreclosure or such other proceeding, or
if Lender takes possession of the Property pursuant to any provisions of the Security Deed or the Assignment of Leases, the lessee thereunder shall be bound to the Purchaser or Lender, as the case may be, under all of the terms, covenants and
conditions of the Lease for the balance of the term thereof and any extensions or renewals thereof which tray be effected in accordance with any option therefor in the Lease, with the same force and effect as if the Purchaser or Lender were the
lessor under the Lease, and Tenant, as lessee under the Lease, does hereby attorn to the Purchaser and Lender if it takes possession of the Property, as its lessor under the Lease. Such attornment shall be effective and self-operative without the
execution of any further instruments upon the succession by Purchaser to the interest of the lessor under the Lease or the taking of possession of the Property by Lender. Nevertheless, Tenant shall, from time to time, execute and deliver such
instruments evidencing such attornment as Purchaser or Lender may require. The respective rights and obligations of Purchaser, Lender and of the lessee under the Lease upon such attornment, to the extent of the then remaining balance of the term of
the Tease and any such extensions and renewals, shall be and are the same as now set forth in the Lease except as otherwise expressly provided in Paragraph 2. 
  

4. SUBORDINATION 
  
 Tenant hereby subordinates all of its right, title and interest as lessee under the Lease to the right, title and interest of Lender under the Security
Deed, and Tenant father agrees that the Lease now is and shall at all times continue to be subject and subordinate in each and every respect to the Security Deed (including, without limitation, the casualty and condemnation provisions of the Lease,
which are hereby specifically subordinated to the Security Deed) and to any and all increases, renewals, modifications, extensions, substitutions, replacements and/or consolidations of the Security Deed. 
  
 Tenant agrees that from and after the date that the Lender, its successors or
assigns, or a court appointed receiver or trustee or a bona fide third-party purchaser shall have obtained fee title to the property pursuant to a foreclosure action or sale, deed-in-lieu of foreclosure or similar proceeding incident to the Security
Deed, any provision in the Lease providing the Tenant with an option to purchase the Property or any part thereof, or with a right of first refusal to purchase the Property or any part thereof, shall be of no further force and effect and shall
automatically terminate as of such date and, notwithstanding any provision of this Agreement or the Lease to the contrary, no such provision shall be binding upon the Lender or its successors and assigns. Without limiting the generality of the
foregoing, no such provision shall apply to a sale of the Property or any portion thereof at foreclosure or incident to a deed-in-lieu of foreclosure or similar proceeding. 
  

 F-3 

 5. ASSIGNMENT OF LEASES 
  
 Tenant hereby acknowledges that all of Landlord’s right, title and
interest as lessor under the Lease is being duly assigned to Lender pursuant to the terms of the Security Deed and the Assignment of Leases, and that pursuant to the terms thereof all rental payments under the Lease shall continue to be paid to
Landlord in accordance with the terms of the Lease unless and until Tenant is otherwise notified in writing by Lender. Upon receipt of any such written notice from Lender, Tenant covenants and agrees to make payment of all rental payments then due
or to become due under the Lease directly to Lender or to Lender’s agent designated in such notice and to continue to do so until otherwise notified in writing by Lender. Landlord hereby irrevocably directs and authorizes Tenant to make rental
payments directly to Lender following receipt of such notice, and covenants and agrees that Tenant shall have the right to rely on such notice without any obligation to inquire as to whether any default exists under the Security Deed or the
Assignment of Leases or the indebtedness secured thereby, and notwithstanding any notice or claim of Landlord to the contrary, and that Landlord shall have no right or claim against Tenant for or by reason of any rental payments made by Tenant to
Lender following receipt of such roller; provided, however, Landlord does, not waive oil release any rights it may have against Lender. Tenant further acknowledges and agrees: (a) that under the provisions of the Security Deed and the Assignment of
Leases, the Lease cannot be canceled or amended (nor can Landlord accept any surrender of the Lease) or terminated (except in accordance with the terminated provisions in the Lease) nor can any consent be given by Landlord to the waiver or release
of Tenant from the performance or observance of, any obligation under the Lease, without, is each instance, the prior written consent of Lender, and without such consent no rent may be collected or accepted by Landlord more than one month in
advance; and (b) that the interest of Landlord as lessor under the Lease has been assigned to Lender for the purposes specified in the Security Deed and the Assignment of Leases, and Lender assumes no duty, liability or obligation under the Lease,
except only under the circumstances, terms and conditions specifically set forth in the Security Deed, the Assignment of Leases and this Agreement. 
  
 6. NOTICE OF DEFAULT BY LESSOR 
  
 Tenant, as lessee under the Lease, hereby covenants and agrees to give Lender
written notice properly specifying wherein the lessor under the Lease has failed to perform any of the covenants or obligations of the lessor under the Lease, simultaneously with the giving of any notice of such default to the lessor under the
provisions of the Lease. Tenant agrees that Lender shall have the right, but not the obligation, within thirty (30) days after receipt by Lender of such notice (or within such additional time as is reasonably required to correct any such default) to
correct or remedy, or cause to be corrected or remedied; each such default before the lessee under the Lease may take a any action under the Lease by reason of such default. Such notices to Lender shall be delivered in duplicate to: 
  
 BankBoston, NA, 
 100 Federal Street 
 Boston, Massachusetts
02110 
 Attn: Real Estate Division 
 and 
  

 F-4 

 Goulston & Stows, P.C. 
 400 Atlantic Avenue 
 Boston, Massachusetts 02110 
 Attn: Michael J. Haroz, Esq. 
  
 or to such other address as the Lender shall have designated to Tenant by giving written notice to Tenant at Tenant’s address set forth on page 1 of this Agreement,
or of such other address as may be designated by written notice from Tenant to Lender. 
  
 7. NO FURTHER SUBORDINATION 
  
 Except as expressly provided to the contrary in Paragraph 4 hereof, Landlord and Tenant covenant and agree with Lender that there shall be no further
subordination of the interest of lessee under the Lease to any lender or to any other party without first obtaining the prior written consent of Lender. Any attempt to effect a further subordination of lessee’s interest under the Lease without
first obtaining the prior written consent of lender shall be null and void. 
  
 8. AS TO LANDLORD AND TENANT 
  
 As between Landlord and Tenant, Landlord and Tenant covenant and agree that nothing herein contained nor anything done pursuant to the provisions hereof
shall be decreed or construed to modify the Lease. 
  
 9.
AS TO LANDLORD AND LENDER 
  
 As between Landlord and Lender, Landlord and Lender covenant and agree that nothing herein contained nor anything done pursuant to the provisions hereof
shall be deemed or construed to modify the Security Deed or the Assignment of Leases. 
  
 10. TITLE OF PARAGRAPHS 
  
 The titles of the paragraphs of this agreement are for convenience and reference only, and the words contained therein shall in no way be held to explain,
modify, amplify or aid in the interpretation, construction or meaning of the provisions of this agreement. 
  
 11. GOVERNING LAW 
  
 This agreement shall be governed by and construed in accordance with the laws of the Commonwealth of Massachusetts. 
  
 12. PROVISIONS BINDING 
  
 The terms and provisions hereof shall be binding upon and shall inure to the
benefit of the heirs, executors, administrators, successors and permitted assigns, respectively, of Lender, Tenant and Landlord. The reference contained to successors and assigns of Tenant is not intended to constitute and does not constitute a
consent by Landlord or Lender to an assignment by Tenant, but 
  

 F-5 

 has reference only to those instances in which the lessor under the Lease and Lender shall have given written consent to
a particular assignment by Tenant thereunder. 
  
 13.
COUNTERPARTS 
  
 This agreement may be executed
in any number of counterparts, each of which may be executed by less than all of the parties, each of which shall be enforceable against the parties actually executing such counterparts, and all of which together shall constitute one instrument.

  
 IN WITNESS WHEREOF, the parties have hereunto set their
respective hands as of the day, month and year first above written. 
  

	Lender:	 	 	 	 BANKBOSTON, NA.

					
	 	 	 	 	 	 	By:	 	 
	 	 	 	 	 	 	 	

					
	 	 	 	 	 	 	Name:	 	 
	 	 	 	 	 	 	 	

					
	 	 	 	 	 	 	Title:	 	 
	 	 	 	 	 	 	 	

					
	 	 	 	 	 	 	Tenant:	 	 
	 	 	 	 	 	 	 	

					
	 	 	 	 	 	 	By:	 	 
	 	 	 	 	 	 	 	

					
	 	 	 	 	 	 	Name:	 	 
	 	 	 	 	 	 	 	

					
	 	 	 	 	 	 	Title:	 	 
	 	 	 	 	 	 	 	

			
	Landlord:	 	 	 	 HMS OFFICE, L.P.
 a Delaware limited partnership

					
	 	 	 	 	 	 	By:	 	 Hines Office Company, L.L.C.
 Its General
Partner

					
	 	 	 	 	 	 	By:	 	 
	 	 	 	 	 	 	 	

					
	 	 	 	 	 	 	Name:	 	 
	 	 	 	 	 	 	 	

					
	 	 	 	 	 	 	Its:	 	 
	 	 	 	 	 	 	 	

			
	Tenant:	 	 	 	 ELAN PHARMACUETICALS, INC.

a Delaware corporation.

					
	 	 	 	 	 	 	By:	 	 
	 	 	 	 	 	 	 	

					
	 	 	 	 	 	 	Name:	 	 
	 	 	 	 	 	 	 	

					
	 	 	 	 	 	 	Title:	 	 
	 	 	 	 	 	 	 	

					
	 	 	 	 	 	 	By:	 	 
	 	 	 	 	 	 	 	

					
	 	 	 	 	 	 	Name:	 	 
	 	 	 	 	 	 	 	

					
	 	 	 	 	 	 	Title:	 	 
	 	 	 	 	 	 	 	

  
  

 F-6 

 FIRST AMENDMENT TO LEASE 
  
 This First Amendment to Lease (“First Amendment”) is made and entered into as of the 25th day of October, 1999 by
and between GATEWAY CENTER, LLC, a California limited liability company (“Landlord”), and ELAN PHARMACEUTICALS, INC., a Delaware corporation (“Tenant”). 
  
 RECITALS: 
  
 A. HMS Office, L.P., a Delaware limited partnership (“Prior Landlord”), predecessor-in-interest to Landlord, and Tenant entered into that
certain Lease dated June 1, 1999 (the “Lease”), permitting to the lease of approximately 9,901 mutable square feet of space (the “Existing Premises”) known as Suites 950 and 980, and located on the ninth (9th) floor of the
building located at 651 Gateway Boulevard, South San Francisco, California (the “651 Building”). 
  
 B. Tenant desires to expand the Existing Premises to include approximately 18,820 rentable square, feet of space, which constitutes the entire eighth
(8th) floor of the building located at 601 Gateway Boulevard, South San Francisco, California (the “601 Building”) known as suite 800 (the “Expansion Premises”), and to make other modifications to the Lease, and in connection
therewith, Landlord and Tenant desire to amend the Lease as hereinafter provided. 
  
 AGREEMENT: 
  
 Now,
THEREFORE, in consideration of the foregoing Recitals and the mutual covenants contained herein, and for other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the parties hereby agree as follows:

  
 1. Premises. 
  
 1.1 Expansion Premises. Effective as of the
“Expansion Premises Commencement Date,” as that team is defined in Section 2 below. Tenant shall lease from Landlord and Landlord shall lease to Tenant the Expansion Premises. Consequently, effective upon the Expansion Premises
Commencement Date, the Existing Premises shall be increased to include the Expansion Premises. The Exiting Premises and the Expansion Premises may herein collectively be referred to as the “Premises.” Landlord and Tenant hereby agree that
the addition of the total Expansion Premises to the Existing Premises shall, increase the size of the “Premises,” as that term is defined in the Lease, to approximately 28,721 rentable square feet. 
  
 1.2 Right of First Offer. Landlord hereby grants to the Tenant
named in the Summary (the “Original Tenant”) a right of first offer with respect to available space located on the seventh (7th) and ninth (9th) floors of the 601 Building (the “First Offer Space”). Notwithstanding the foregoing,
such first offer right of Tenant shall be subordinate to all rights of which are set forth in leases of space in the Project as of the date hereof, including any renewal, extension or expansion rights set forth in such leases, regardless of whether
such renewal, extension or expansion rights are 

 executed strictly in accordance with their terms, or pursuant to a lease amendment or a new lease (collectively, the
“Superior Right Holders”) with respect to such First Offer Space. Tenant’s right of first offer shall be on the terms and conditions set forth in this Section 1.2. 
  
 1.2.1 Procedure for Offer. Tenant shall notify Landlord from time to time in the event Tenant is interested
in leasing First Offer Space (the “Interest Notice”). For the six (6) months immediately following Landlord’s receipt of an Interest Notice, Landlord shall promptly notify Tenant in the event First Offer Space or any portion thereof
becomes available for lease to third parties, provided that no Superior Right Holder wishes to lease such space (the “First Offer Notice”) and such first Offer Space is not then subject to negotiation of a lease proposal or lose document
with a prospective tenant. In the event no First Offer Space becomes available during the six (6) months following Landlord’s receipt of an Interest Notice, Tenant shall have the option to deliver another Interest Notice to Landlord. Pursuant
to such First Offer Notice, Landlord shall offer to lease to Tenant the then available First Offer Space. The First Offer Notice shall describe the space so offered to Tenant and shall set forth the “First Offer Rent,” as that term is
defined in Section 12.3 below, and the other economic teems upon which Landlord is willing to lease such space to Tenant. 
  
 1.2.2 Procedure for Acceptance. If Tenant wishes to exercise Tenant’s light of first offer with respect to the space described in the
First Offer Notice, then within five (5) business days of delivery of the First Offer Notice to Tenant, Tenant shall deliver notice to Landlord of Tenant’s intention to exercise its right of first offer with respect to the entire space
described in the First Offer Notice on the terms contained in such notice. If Tenant does not so notify Landlord within the five (5) business day period, then Landlord shall be free to lease the space described in the First Offer Notice to anyone to
whom Landlord desires on any terms Landlord desires. Notwithstanding anything to the contrary contained herein, Tenant must elect to exercise its right of first offer, if at all, with respect to all of the space offered by Landlord to Tenant at any
particular time, and Tenant may not elect to lease only a portion thereof. 
  
 1.2.3 First Offer Space Rent. The “Rent,” as that term is defined in Section 4.1, below, payable by Tenant for the First Offer Space (the “First Offer Rent”) shall be equal to rent
(including additional rant and considering any “base year” or “expense stop” applicable thereto); including all escalations, at which tenants, as of the “First Offer Commencement Date,” as that term defined in
Section 1.2.5, below, are leasing non-sublease, non-encumbered, non-equity space comparable in size, location and quality to the First Offer Space for a similar lease term, which comparable space is low in the Project, taking into
consideration the following concessions: (a) rental abatement concessions, if any, being granted such tenants in connection with such comparable space, (b) tenant improvements or allowances provided or to be provided for such comparable space,
taking into account and deducting the value of, the existing improvements in the First Offer Space, such value to be based upon the age, quality and layout of the improvements and the extent to which the same could be utilized by a general office
user, and (c) any period of rental abatement, if any, granted to tenants in comparable transactions in connection with the design, permitting and construction of tenant improvements in such comparable spaces. 
  

 -2- 

 1.2.4 Construction in First Offer Space. Tenant shall take the First Offer Space in its
“as is” condition, and the construction of improvements in the First Offer Space shall comply with the terms of Article 10 of the Lease. 
  
 1.2.5 Amendment to Lease. If Tenant timely exercises Tenant’s right to lease the First Offer Space as set forth herein, Landlord and
Tenant shall within fifteen (15) days thereafter execute a separate lease for such First Offer Space: upon the terms and conditions as set forth in the First Offer Notice and this Section 1.2. Tenant shall commence payment of Rent for the First
Offer Space, and the term of the First Offer Space shall commence upon the date of delivery of the First Offer Space to Tenant (the “First Offer Commencement Date”) and terminate on the date set forth in the First Offer Notice. 

 
 1.2.6 Termination of Right of First Offer. The rights
contained in this Section 1.2 be personal to the Original Tenant, and may only be exercised by the Original Tenant or a permitted Assignee pursuant to Article 20 of the Lease (and not any other assignee, sublessee or other transferee of the
Original Tenant’s interest in this Lease) if the Original Tenant or such permitted Assignee occupies the entire Premises. The right of first offer granted herein shall terminate as to particular First Offer Space upon the failure by Tenant to
exercise its right of first offer with respect to such First Offer Space as offered by Landlord. Tenant shall not have the right to lease First Offer Space, as provided in this Section 1.2, if, as of the date of the attempted exercise of any
right of first offer by Tenant, or as of the scheduled date of delivery of such First Offer Space to Tenant, Tenant is in default under this Lease or Tenant has previously been in default under this Lease more than once. 
  
 2. Term. 
  
 2.1 Initial Lease Term. The term of Tenants lease of the
Expansion Premises (the “Expansion Term”) shall commence on December 15, 1999 (the “Expansion Premises Commencement Date”), and shall expire, along with Tenants lease of the Existing Premises; on December 14, 2004, unless sooner
terminated as provided in the Lease, as hereby amended. 
  
 2.2
Option Term 
  
 2.2.1 Option Right. Landlord
hereby grants the Original Tenant one (1) option to extend the Lease Term for a period of five (5) years (the “Option Term”), which option shall be exercisable only by written notice delivered by Tenant to Landlord as provided below,
provided that, as of the date of delivery of such notice, Tenant is not in default under this Lease. Upon the proper exercise of such option to extend, and provided that, at Landlord’s option, as of the end of the initial Lease Term, Tenant is
not in default under this Lease, the Lease Term, as it applies to the Premises, shall be extended for a period of five (5) years. The rights contained in this Section 2.2 shall be personal to the Original Tenant or a permitted Assignee pursuant to
Article 20 of the Lease, and may only be exercised by the Original Tenant or such permitted assignee (and not any other assignee, sublessee or other transferee of the Original Tenant’s interest in this Lease) if the Original Tenant occupies the
entire Premises. 
  

 -3- 

 2.2.2    Option Rent.    The Rent payable by
Tenant ding the Option Term (the “Option Rent”) shall be equal to the rent (including additional rent and considering any “base year” or “expense stop” applicable thereto), including all escalations, at which tenants as
of the commencement of the Option Term, are leasing non-sublease, non-encumbered space comparable in size, location and quality to the Premises for a term of five (5) years, which comparable space is located in the Building, at the building located
at 601 Gateway Boulevard, or within a five (5) mile radius of the Building, taking into consideration the following concessions: (a) rental abatement concessions, if nay, being granted such tenants in connection with such comparable spaces and (b)
tenant improvements or allowances provided or to be provided for such comparable space, taking into account, and deducting the value of, the existing improvements in the Premises, such value to be based upon the age, quality and layout of the
improvements and the extent to which the same could be utilized by Tenant based upon the fact that the precise tenant improvements existing in the Premises are specifically suitable to Tenant. 
  
 2.2.3    Exercise of
Options.    The option contained in this Section 2.2 shall be exercised by Tempt, if at all, and only in the following warmer: (i) Tenant shall deliver written notice to Landlord not more than eight (8) months nor
less than seven (7) months prior to the expiration of the initial Lease Term, stating that Tenant is interested in exercising its option; (ii) Landlord, after receipt of Tenant’s notice, shall deliver notice (The “Option Rent Notice”)
to Tenant not less than five (5) months prior to the expiration of the initial Lease Term, setting forth the Option Rent; and (iii) if Tenant wishes to exercise such option, Tenant shall, on or before the earlier of (A) the date occurring four (4)
months prior to the expiration of the initial Least Term, and (B) the date occurring thirty (30) days after Tenant’s receipt of the Option Rent Notice, exercise the option by delivering written notice thereof to Landlord and upon, and
concurrent with, such exercise, Tenant may, at its option, object to the Option Rent contained in the Option Rent Notice, in which case the parties shall follow the procedure, and the Option Rent shall be as set forth in Section 2.2.4 below.

  
 2.2.4    Determination of Option
Rent.    In the event Tenant timely objects to the Option Rent, Landlord and Tenant shall attempt to agree upon the Option Rent using their best good faith efforts. If Landlord and Tenant fail to reach agreement within
ten (10) business days following Tenant’s objection to the Option Rent (the “Outside Agreement Date”), then each party shall make a separate determination of the Option Rent within five (5) business days after the Outside Agreement
Date, end such determinations shall be submitted to arbitration in accordance with Sections 2.2.4.1 through 2.2.4.7 below. 
  
 2.2.4.1    Landlord and Tenant shall each appoint one (1) arbitrator who shall be a real estate broker who shall have been active
over the five (5) year period ending on the date of such, appointment in the leasing of commercial high-rise properties in South San Francisco, California. The determination of the arbitrators shall be limited solely to the issue of whether
Landlord’s or Tenant’s submitted Option Rent is the closest to the actual Option Rent as determined by the arbitrators, taking into account the requirements of Section 2.2.2 of this Lease. Each such arbitrator shall be appointed within
fifteen (15) days after the Outside Agreement Date. 
  

 -4- 

 2.2.4.2    The two (2) arbitrators so appointed shall within ten (10) days of the
date of the appointment of the last appointed arbitrator agree upon and appoint a third arbitrator who shall be qualified under the same criteria set forth herein above for qualification of the initial two (2) arbitrators. 
  
 2.2.4.3    The three (3) arbitrators shall within thirty
(30) days of the appointment of the third arbitrator reach a decision as to whether the parties shall use Landlord’s or Tenant’s submitted Option Rent and shall notify Landlord and Tenant thereof. 
  
 2.2.4.4    The decision of the majority of the three (3)
arbitrators shall be binding upon Landlord and Tenant. 
  
 2.2.4.5    If either Landlord or Tenant fails to appoint an arbitrator within fifteen (15) days after the Outside Agreement Date, then the arbitrator appointed by one of them shall reach a decision notify Landlord and
Tenant hereof, and such arbitrator’s decision shall be binding upon Landlord and Tenant. 
  
 2.2.4.6    If the two (2) arbitrators fail to agree upon and appoint a third arbitrator, or if both parties fail to appoint an arbitrator, then the appointment of the third arbitrator or any
arbitrator shall be dismissed and the matter to be decided shall be forthwith submitted to arbitration under the provisions of the American Arbitration Association but subject to the instruction set forth in this Section 2.2.4. 
  
 2.2.4.7    The cost of the arbitration shall be paid by
Landlord and Tenant equally. 
  
 3.    Rent. 
  
 3.1    Base Rent for Expansion Premises.    Tenant shall continue to pay Base Rent and Additional Rent for the Existing Premises in accordance with the term of the Lease. Notwithstanding
any contrary provision of the Lease, as hereby amended, commencing on the Expansion Premises Commencement Date and continuing throughout the Expansion Term. Tenant shall pay to Landlord annual Base Rent in connection with the Expansion Premises in
the following amounts. 
  

	 Months of Lease Term

	 	 Annual Rental Rate

	 	 Monthly Base Rate

	 	 Monthly Base Rent
per Square Foot

	1-24	 	$474,264.00	 	$39,522.00	 	$2.10
	25-48	 	$496,848.00	 	$41,404.00	 	$2.20
	49-60	 	$519,432.00	 	$43,286.00	 	$2.30

  
 Upon Tenant’s
execution and delivery of this First Amendment, Tenant shall pay to Landlord the monthly installment of Base Rent for the Expansion Premises payable for the first full month of the Expansion Term. 
  

 -5- 

 3.2    Tenant’s Share of Operating
Expenses.    Tenant shall continue to pay to Landlord Tenant’s Share of Operating Expenses in connection with Tenant’s lease of the Existing Premises in accordance with the terms of the Lease. Notwithstanding
anything in the Lease, as hereby amended, to the contrary, commencing as of the Expansion Premises Commencement Date, Tenant shall pay Tenant’s Share of Operating Expenses in connection with Tenant’s lease of the Expansion Premises in
accordance with the terms of Article 4 of the Lease, as amended; provided, however, that effective as of the Expansion Premises Commencement Date, the Lease, as amended, as it pertains to the Expansion Premises, shall be converted into a
“Triple Net” lease. Tenant recognizes and acknowledges, without limiting the generality of any other terms or provision of the Lease, as amended, that it is the intent of the parties hereto that any and all expenses incurred in connection
with the Premises or the 601 Building, or the operations thereon, including any and all taxes assessments, general or special license fees, insurance premiums, public utility bills, and costs of repair, maintenance and operation of the premises and
the 601 Building and all structures, improvements or permanent fixtures comprised therein, together with the appurtenances thereto, shall be paid by Tenant in addition to the Base Rent specified in the Lease, as amended. All references in the Lease
to an Operating Expense Base shall be of no force and effect with respect to the Expansion Premises. 
  
 4.    Signage.    Subject to the terms of this Section 4, and provided Tenant occupies an
entire floor of the Building, Tenant shall be entitled, at its sole cost and expense install the following signage: 
  
 (i)  Exclusive building top signage for the 601 Building, as follows: two (2) signs identifying Tenant located at the top of the 601 Building,
one (1) facing highway 101 and one (1) facing Gateway Boulevard, such signs to be subject to all applicable laws and regulations, and Landlord’s reasonable approval. Tenant shall pay to Landlord the sum of Two Thousand Five Hundred and No/100
Dollars $2,500.00 per month as a fee for such signage during the first year of the Expansion Term (the “Signage Fee”), and on the first anniversary of the Expansion Term and each anniversary thereafter (the “CPI Adjustment
Date”), the Signage Fee shall be increased to equal the product of (i) the Signage Fee, as the same may have been previously increased pursuant to this Section 4, multiplied by (ii) a fraction, the numerator of which is the “Adjustment
Month Index,” as that term is defined in Section 4(A)(1) below, occurring prior to such CPI Adjustment Date and the denominator of which is either (I) for the Initial CPI Adjustment Date, the “Base Month Index,” as that term is
defined in Section 4(A)(2) below, or (II) for all subsequent CPI Adjustment Dates, the Adjustment Month Index used as the numerator for the previous CPI Adjustment Date; 
  
 A)  Base Rent Adjustment Definitions.    As used in this Lease, the following terms
shall have the meanings hereinafter set forth: 
  
 1)  “Adjustment Month Index” shall mean the “Index,” as that term is defined in Section 4(A)(3), below, for that month which is the same calendar month as the Base Month Index immediately preceding each
succeeding CPI Adjustment Date. 
  
 2)  “Base
Month Index” shall mean the Index for the third month immediately preceding the month in which the Initial Adjustment Date occurs. By way of example 

  

 -6- 

 
only, if the Expansion Premises Commencement Date were to occur on December 1, 1999, then the Initial Adjustment Date would occur on December 1, 2000, the
Base Month index would be the Index for September, 2000, and the Adjustment Month Index for each succeeding CPI Adjustment Dane would be the Index for that month of September immediately preceding such CP1 Adjustment Date. 
  
 3)  “Index” shall mean the Consumer Price Index for all
Urban Consumers for the San Francisco area (base year 1982 1984 100), published by the United States Department of Labor. Bureau of Labor Statistics. If the base of the Index changes from the 1982 -84 base (100), the Index shall, thereafter, be
adjusted to the 1982-84 base 100 before the computation indicated above is made. If the Index cannot be converted to the 1982-84 base or if the Index is otherwise revised, the adjustment under this section shall be made with the use of such
conversion factor, formula or table for converting the Index as may be published by the Bureau of Labor Statistics. If the Index is at any time no longer published, a comparable index generally accepted and employed by the real estate profession, as
determined by Landlord in Landlord’s sole but reasonable discretion, shall be used. 
  
 (ii)  Building standard interior signage, consistent with Landlord’s standard signage criteria. 
  
 5.    Parking.    Effective as of the Expansion Premises Commencement Date and continuing
throughout the Expansion Terns, and notwithstanding any contrary provision in the Lease, Tenant shall have the right, free of charge, to unreserved parking passes at the 601 Building parking facility at a ratio of three and three tenths (3.3) passes
per 1,000 rentable square feet of the Expansion Premises, of which up to three (3) may be for the use of a reserved parking space in a location reasonably designated by Tenant, subject to availability. Except as set forth in this Section 5, Tenant
shall lease the parking passes for the Expansion Premises in accordance with the provisions of Section 26.5 of the Lease. 
  
 6.    Assignment and Subletting.    The provisions of Article 20 of the Lease shall apply to
Tenant’s right to assign or sublease the Expansion Premises; provided, however, that notwithstanding the provisions of Section 20.3, any rent at other consideration pertaining to the Expansion Premises realized by Tenant, in excess of the Rent
payable pursuant to the Lease, as amended (the “Transfer Premium”), shall be allocated as follows: fifty percent (50%) to Tenant and fifty percent (50%) to Landlord. Such Transfer Premium shall be calculated pursuant to the terms of
Section 20.3 of the Lease, as amended. 
  
 7.    Brokers.    Landlord and Tenant hereby warrant to each other that they have had no dealings with any real estate broker or agent in connection with the negotiation of this
Fifth Amendment, and that they know of no real estate broker or agent other than CRESA Partners (the “Broker”) who is entitled to a commission in connection with this Fifth Amendment. Each party agrees to indemnify and defend the ether
party against and hold the other party harmless from any and all claims, demands, losses, liabilities, lawsuits, judgments, end costs and expenses (including, without limitation, reasonable attorneys’ fees) with respect to any leasing
commission or equivalent compensation alleged to be owing on account of the indemnifying party’s dealings with any real 

  

 -7- 

 
estate broker or agent other than the Broker. The terms of this Section shall survive the expiration or earlier termination of this Fifth Amendment.

  
 8.    Improvement
Allowance.    Tenant shall be entitled to a one-time allowance for the purchase and installation of improvements which are permanently affixed to the Premises (the” Improvements”) in the amount of up to
$112,920.00 (i.e., $6.00 per rentable square foot of the Premises multiplied by 18,820 rentable square square feet) (the “Improvement Allowance”). The construction and installation of the Improvements shall be made in accordance
with the terms of Section 10.2 of the Lease, and the Improvements shall be deemed Alterations for all purposes hereunder. The Improvement Allowance shall be disbursed by Landlord pursuant to Landlord’s disbursement process. All costs related to
the construction of the Improvements in excess of the Improvement Allowance (as the same may be reduced by the application of the same as a credit against Base Rent in accordance with the foregoing sentence) shall be paid by Tenant in accordance
with Section 10.2 of the Lease. In the event that Improvement Allowance is not fully utilized by Tenant within one (1) year following the Expansions premises Commencement Date (either to pay for costs related to the construction of the Improvements
or as a credit against Base Rent), then such unused amounts shall reveal to Landlord and Tenant shall have no further rights with respect thereto. Tenant shall have the right to select its own architect and contractor(s) for the interior
improvements, subject to Landlord’s prior approval, which shall not be unreasonably withheld. Landlord shall not charge a free to supervise Tenant’s construction work within the Premises. 
  
 8.    Defined
Terms.    Except as explicitly set forth in this First Amendment, all defined terns herein shall have their respective meanings as set forth in the Lease and the terms and provisions of the Lease are unmodified and shall
remain in full force and effect. 
  
 9.    No Further Modification.    Except as specifically set forth in this First Amendment, all of the terms and provisions of the Lease shall remain unmodified and in full force
and effect. In the event of any conflict between the terms and conditions of the Lease and the terms and conditions of this First Amendment, the terms said conditions of this First Amendment shall prevail. 
  

 -8- 

 IN WITNESS WHEREOF, Landlord and Tenant have caused this First Amendment to be executed on the day and
date first above written. 
  

	 “LANDLORD”
  
 GATEWAY CENTER LLC.,
 a California limited liability
company

		
	By:	 	/S/    BOB PESTER        
	 	 	

			
	 	 	Its:	 	Senior Vice President and Regional Manager
	 	 	 	 	

	
	 “TENANT”
  
 ELAN PHARMACEUTICALS, INC.
 a Delaware company

		
	By:	 	/S/    [SIGNATURE ILLEGIBLE]        
	 	 	

			
	 	 	Its:	 	VP, Commercial and Legal Affairs
	 	 	 	 	

		
	By:	 	 
	 	 	

			
	 	 	Its:	 	 
	 	 	 	 	

  

 -9- 

 EXHIBIT B 
  

GATEWAY COMMONS 
  

 -11- 

 EXHIBIT B 
  
 GATEWAY COMMONS 
  
 [Insert Picture] 
  

 -12- 

 EXHIBIT C 
  

PERSONAL PROPERTY INVENTORY 
  
 1 Gray Reception Cube w/ 2 overhead cabinets 
  
 4 Cubes w/2 overhead cabinets per cube 
  
 2 Gray desks (1 in each office) 
  
 1 large White board in Conference Room 
  

 -13- 

 EXHIBIT D 
  

STORAGE AGREEMENT 
  
  

 -14- 

 STORAGE AGREEMENT 
  
 This Storage Agreement (this “Agreement”) is entered into as of the
             day of                      2003, by and between Gateway
Center LLC, a California limited liability company (“Landlord”), and TENANT NAME, a ENTITY (“Tenant”). 
  
 RECITALS: 
  
 A. Landlord and Tenant entered into that certain Office Lease (the “Lease) dated
                    , pursuant to which Tenant leases approximately      rentable square feet of office space (the
“Premises”) in that certain building located in South San Francisco, California and commonly known as 651 Gateway Blvd. (the “Building”) which building is owned by Landlord. 
  
 B. In connection with the Lease, Tenant desires to have the right to lease
from Landlord certain storage facilities located in the building, and Landlord has agreed to give certain rights to lease the storage facilities to Tenant. Initially capitalized terms not otherwise defined in this Agreement shall have the same
meaning as provided for in the Lease: 
  
 AGREEMENT:

  
 SECTION 1 
 LEASE OF THE STORAGE AREA 
  
 Tenant hereby leases from Landlord approximately              rentable square feet of
storage space (the “Storage Area”), which Storage Area shall be located as set forth on Exhibit ”A” attached hereto and made a part hereof, and shall be referred to as Space S-    . 
  
 SECTION 2 
 TERM 
  
 The term of this lease of the Storage Area to Tenant shall commence on
                     (the “Storage Commencement Date”), and shall continue thereafter on a month-to-month basis. Either party shall
have the right to terminate this Agreement at any time, upon not less than thirty (30) days’ prior written notice to the other party. In any event, this Agreement shall terminate upon the expiration or any earlier termination of the term of the
Lease. 
  
 SECTION 3 
 STORAGE RENT 
  
 Tenant shall pay “Storage Rent” beginning on the Storage Commencement Date
             as follows: 

	 Period of Term

	 	 Monthly
Storage Rent

	 	 Monthly Rate of
Storage Rent per
Rentable Square Foot

 of Storage Area

	 Storage Commencement
 Date through expiration of
Storage Area Term
	 	$XXXX	 	$XXX

  
 Such Storage Rent
shall be payable in monthly installments on the first day of each month during which Storage Rent is owed hereunder, in advance, except that if the Storage Commencement Date occurs on a day other than the first day of the month, then the monthly
Storage Rent for the fraction of the month starting with the Storage Commencement Date shall be paid on the Storage Commencement Date, prorated on the basis of the actual number of days in such month. If the term of this Agreement ends on a day
other than the last day of a month, then the Storage Rent for the month during which such expiration occurs shall be prorated on the basis of the actual number of days in such month. In the event the Storage Rent is not paid when due, Landlord shall
have the same rights as provided in [Section/Article     ] of the Lease for unpaid rent. The Storage Rent is subject to periodic adjustments by Lessor to reflect increased costs relating to the Storage Area or the current
rental value of such space. Landlord shall provide to the Storage Area lighting adequate for storage use; no other services or utilities (including, without limitation, heating, cooling or cleaning) shall be provided to the Storage Area. 

 
 SECTION 4 
 INDEMNIFICATION 
  
 Tenant agrees and acknowledges that its use of the Storage Area is at its sole risk, and Tenant hereby waives and absolves Landlord from any and all cost,
loss, damage, expense, and liability, whether foreseeable or not, from any cause whatsoever, that Tenant may suffer to its personal property located anywhere in the Storage Area or that it or its agents, employees, principals, invitees, and
licensees may suffer as a direct or indirect consequence of Tenant’s lease of or use of the Storage Area or access areas to the Storage Area or for any other reason arising from or related to this Agreement. In addition, Tenant hereby agrees to
indemnify, defend, protect, and hold Landlord harmless from and against any loss, cost; damage, liability, expense, claim, action or cause of action of any third party, whether foreseeable or not, resulting as a direct or indirect consequence of
Tenant’s lease or use of the Storage Area or access areas to the Storage Area or for-any other reason arising from or related to this Agreement. 
  
 SECTION 5 
 USE AND
MAINTENANCE OF STORAGE AREA 
  
 Tenant agrees not to store
any flammable, combustible or other materials in the Storage Area that would increase the cost of Landlord’s insurance, and not to store any toxic or hazardous material or waste in the Storage Area. Tenant also agrees not to store excess or
highly concentrated weight in the Storage Area; it shall be Tenant’s responsibility to obtain from Landlord the tolerable limits 
  

 -2- 

 hereof. Landlord shall have the right to require any or all items stored in the Storage Area to be stored on pallets.
Tenant agrees to use the Storage Area solely for storage purposes of dry goods and not as office space. Tenant agrees that Landlord and its agents may enter and inspect the Storage Area and any goods stored therein at any time upon giving reasonable
notice to Tenant. Tenant accepts the Storage Area in its “as is,” “with all faults,” “without any warranties or representations” condition, and shall alter (with Landlord’s prior approval, which approval shall not
be unreasonably withheld or delayed), maintain and repair the Storage Area at its sole cost and expense. Tenant acknowledges that, as of the date of this Agreement, the California Fore Code requires an eighteen inch (18”) vertical clearance
between sprinkler heads and all items stored in the Storage Area, and, without limiting any other obligation of Tenant hereunder or under the Lease, Tenant hereby agrees to comply with this requirement, as it may be modified from time to time.

  
 SECTION 6 
 DEFAULTS 
  
 Breach of any of its covenants hereunder by Tenant shall, at the option of Landlord, also constitute a default under the Lease. A default under the Lease
by Tenant shall, at the option of Landlord, immediately constitute a default hereunder. 
  
 SECTION 7 
 NOTICES 
  
 Any nonce required or permitted to be given hereunder by Tenant or Landlord shall be given pursuant to the terms of
Section/Article      of the Lease, except that notices to Landlord shall be addressed to Gateway Center LLC, the address of which is c/o Boston Properties L. P., Suite One—Lobby Level, Four Embarcadero Center, San
Francisco, CA 94111. 
  
 SECTION 8 
 RELOCATION OF STORAGE AREA 
  
 Landlord reserves the right, upon not less than thirty (30) days’ prior written notice to Tenant, to substitute for the Storage Area comparable
storage area within the Building having substantially equivalent usable area as the Storage Area, provided that Landlord shall pay all expenses reasonably incurred in moving Tenant’s property to such new location; and upon the expiration of
such 30-day written notice, the new storage area shall be deemed to be the Storage Area covered by this Agreement. If the new storage area is less than the Storage Area as it existed before the substitution, monthly Storage Rent shall be reduced by
a sum computed by multiplying the monthly Storage Rent by a fraction, the numerator of which shall be total number of usable square feet in the new storage area and the denominator of which shall be the total number of usable square feet in the
Storage Area before substitution. 
  

 -3- 

 SECTION 9 
 INCORPORATION OF LEASE PROVISIONS 
  
 All applicable provisions of the Lease shall be deemed to apply to the Storage Area as though Landlord were the landlord under the Lease and the Storage Area were part of the Premises, and as though the, Storage Rent
were part of base rent, and such provisions are hereby incorporated into this Agreement by this reference as though fully set forth herein. In no event shall any damage to or destruction of the Storage Area cause a termination of the Lease under
Section/Article              thereof. In the event of any conflict between the provisions of this Agreement and the provisions of the Lease, the terms of this Agreement shall govern.

  
 IN WITNESS WHEREOF, the parties have entered into this
Agreement as of the date first written above. 
  

	“Landlord”:	 	 	 	“Tenant”:
			
	 GATEWAY CENTER, LLC,
 A
California limited liability company
	 	 	 	 TENANT NAME
 a
ENTITY

					
	By:	 	 Boston Properties LLC,
 its managing general
partner
	 	 	 	By:	 	

					
	 	 	 	 	 	 	Its:	 	

					
	By:	 	 Boston Properties L.P.,
 its managing general
partner
	 	 	 	By:	 	

					
	 	 	 	 	 	 	Its:	 	

					
	By:	 	 Boston Properties, Inc.,
 its managing
general partner
	 	 	 	By:	 	

					
	 	 	 	 	 	 	Its:	 	

					
	By:	 	
	 	 	 	 	 	 
	 	 	 Bob Pester
 Sr. Vice President and Regional
Manager
	 	 	 	 	 	 

  
  

 -4- 

 EXHIBIT F 
  

FORM GENERAL WARRANTY BILL OF SALE 
  
 This General Warranty Bill of Sale (“Bill of Sale”) is made and delivered by ELAN PHARMACEUTICALS, INC., a Delaware corporation,
(“Seller”) to TERCICA MEDICA, INC., a Delaware corporation (“Buyer”), as of [INSERT DATE HERE]. 
  
 RECITALS 
  
 A. Seller has agreed to transfer to Buyer all of Seller’s right, title and interest in and to the personal property (“Personal Property”)
owned by Seller and located on the Premises, as described in Exhibit 1 attached hereto and incorporated herein by reference and pursuant to this Bill of Sale. 
  

B. Buyer is willing to pay to Seller the sum of One Dollar ($1.00) inclusive of all sales tax thereon, if any, for the Personal Property, “as
is,” and “where is,” and “with all faults”. 
  
 C. Seller is willing to warrant to Buyer that it is the lawful owner of the Personal Property. 
  
 WITNESSETH 
  
 l. Seller hereby grants, sells, transfers, assigns, conveys and delivers to Buyer all of Seller’s right, title and interest in and to the Personal Property, including, without limitation, the Personal Property specified in attached
Exhibit 1. 
  
 2. The Personal Property is conveyed, sold and
transferred to Buyer “as is,” and “where is,” and “with all faults” from Seller. 
  
 3. Buyer shall pay to Seller contemporaneously on receipt of this Bill of Sale, executed by the Seller, the sum of One Dollars ($1.00) inclusive of all
sales tax thereon to be reimbursed to Seller. 
  
 4. Seller
represents and warrants that Seller is the lawful owner of the Personal Property transferred hereunder, free and clear of all mortgages, liens or encumbrances of any kind or nature. 
  
 5. Seller hereby agrees that it will, upon written request by Buyer, execute and deliver to Buyer any new or confirmatory
instruments and do and perform any other acts which Buyer may reasonably request and actually require in order to fully assign and transfer to and vest in Buyer all right, title, interest and enjoyment of the Personal Property. 
  
 6. All references to “Seller” and “Buyer” herein shall be
deemed to include Seller’s and Buyer’s respective heirs, representatives, nominees, successors and/or assigns, as the case may be. 

	 SELLER:
  
 ELAN PHARMACEUTICALS, INC.,
 a Delaware corporation

		
	By	 	 
	 	 	

		
	Name:	 	 
	 	 	

		
	Title:	 	 
	 	 	

	
	 BUYER:
  
 TERCICA MEDICA, INC.,
 a Delaware corporation

		
	By	 	/S/    HOWARD MOORE        
	 	 	

		
	Name:	 	Howard S. Moore
	 	 	

		
	Title:	 	Executive Vice President
	 	 	

  

 -2- 

 EXHIBIT 1 
  

PERSONAL PROPERTY INVENTORY 
  
 1 Gray Reception Cube w/2 overhead cabinets 
  
 4 Cubes w/2 overhead cabinets per cube 
  
 2 Gray desks (1 in each office) 
  
 1 large White board in Conference Room 
  
 1
Projector Screen in Conference Room 
  
 1 Refrigerator in Kitchen 
  
  

 -1- 

 CONSENT TO SUBLEASE AGREEMENT 
  
 THIS CONSENT TO SUBLEASE AGREEMENT (this “Agreement”) is made as of April 1, 2003, by and among GATEWAY CENTER,
LLC, a Delaware limited liability company (“Landlord”), ELAN PHARMACEUTICALS, INC., a Delaware corporation (“Tenant”), and TERCICA MEDICA, INC., a Delaware corporation (“Subtenant”). 
  
 R E C I T A L S: 
  
 A. Reference is hereby made to that certain Office Lease dated June 1, 1999,
between Landlord and Tenant (the “Office Lease”), as amended by that certain First Amendment to Lease dated as of October 25, 1999 (collectively, the “Lease”), for space on the eighth (8th) and ninth (9th) floors (the
“Premises”) in that certain office building commonly known as 651 Gateway Boulevard, South San Francisco, California (the “Building”). 
  
 B. Pursuant to the terms of Section 20 of the Office Lease, Tenant has requested Landlord’s consent to that certain Sublease dated March 21, 2003,
between Tenant and Subtenant (the “Sublease”), with respect to a subletting by Subtenant of a portion of the Premises known as Suite 980 located on the ninth (9th) floor of the Building, as more particularly described in the Sublease (the
“Sublet Premises”). A copy of the Sublease is attached hereto as Exhibit A. Landlord is willing to consent to the Sublease on the terms and conditions contained herein. 
  
 C. All defined terms not otherwise expressly defined herein shall have the respective meanings given in the Lease.

  
 A G R E E M E N T: 
  
 1. Landlord’s Consent. Landlord hereby consents to the Sublease;
provided however, notwithstanding anything contained in the Sublease to the contrary, such consent is granted by Landlord only upon the terms and conditions set forth in this Agreement. The Sublease is subject and subordinate to the Lease. Landlord
shall not be bound by any of the terms, covenants, conditions, provisions or agreements of the Sublease. 
  
 2. Non-Release of Tenant; Further Transfers. Neither the Sublease nor this consent thereto shall release or discharge Tenant from any liability,
whether past, present or future, under the Lease or alter the primary liability of Tenant to pay the rent and perform and comply with all of the obligations of Tenant to be performed under the Lease: (including the payment of all bills rendered by
Landlord for charges incurred by Subtenant for services and materials supplied to the Sublet Premises). Neither the Sublease nor this consent thereto shall be construed as a waiver of Landlord’s right to consent to any further subletting either
by Tenant or by Subtenant or to any assignment by Tenant of the Lease or assignment by Subtenant of the Sublease, or as a consent to any portion of the Sublet Premises being used or occupied by any other party. Landlord may consent to subsequent
sublettings and assignments of the Lease or the Sublease or any amendments or modifications thereto without notifying Tenant nor anyone else liable under the Lease and without 
  

 -1- 

 obtaining their consent. No such action by Landlord shall relieve such persons from any liability to Landlord or
otherwise with regard to the Sublet Premises. 
  
 3.
Relationship With Landlord. Tenant hereby assigns and transfers to Landlord all of Tenant’s interest in the Sublease and all rentals and income arising therefrom, subject to the terms of this Section 3. If an Event of Default (as defined
in Section 9.1 of the Office Lease) occurs (whether or not Landlord terminates the Lease), or if a voluntary or involuntary termination of the Lease occurs for any reason, then Landlord may elect, at its option by notice to Tenant, either (i) to
terminate the Sublease; (ii) to keep the Lease in full force and effect (provided that the Lease has not been terminated by Landlord or otherwise), and to receive and collect (or to continue to receive and collect, as the case may be) directly from
Subtenant all rent and other sums owing and to be owed under the Sublease, as further set forth in Section 3.1, below, it being understood that, notwithstanding anything to the contrary contained in the Lease, and in addition to Landlord’s
other rights and remedies contained in the Lease, upon the occurrence of an Event of Default under the Lease, Landlord shall have the remedy described in California Civil Code Section 1951.4 (Landlord may continue lease in effect after Tenant’s
breach and abandonment and recover rent as it becomes due, if Tenant has the right to sublet or assign, subject only to reasonable limitations); or (iii) to terminate the Lease and to succeed to Tenant’s interest in the Sublease and cause
Subtenant to attorn to Landlord, as further set forth in Section 3.2, below. 
  
 3.1 Landlord’s Election to Receive Rents. Tenant hereby irrevocably authorizes and directs Subtenant, upon receipt of written notice from Landlord (which notice may be delivered by Landlord whether or not
an Event of Default has occurred under the Lease, and which notice shall be delivered to Tenant concurrently with Landlord’s delivery of such notice to Subtenant) and at the direction of Landlord, to pay directly to Landlord any or all rents
and/or other sums due or to become due under the Sublease, and Tenant hereby agrees that Subtenant shall have the right to rely upon any such written notice from Landlord, and that Subtenant shall pay any such rents and/or other sums directly to
Landlord without any obligation or right of inquiry and notwithstanding any notice from or claim of Tenant to the contrary. Until such time as Landlord shall deliver written notice to Tenant and Subtenant in accordance with the foregoing sentence,
Landlord agrees that Tenant may receive, collect and enjoy the rents accruing under the Sublease. Landlord shall not, by reason of the Sublease, nor by reason of the collection of any rents or any other sums from Subtenant pursuant to this Section
3.1, be deemed liable to Subtenant for any failure of Tenant to perform and comply with any obligation of Tenant. Tenant shall not have any right or claim against Subtenant for any such rents or other sums so paid by Subtenant to Landlord. Neither
Landlord’s acceptance of any payment on account of rent or any other sums from Subtenant (regardless of the circumstances therefor and whether or not any Event of Default has occurred under the lease) nor Landlord’s acceptance of
performance by Subtenant of any obligations of Tenant under the Lease shall in any manner whatsoever (i) be deemed an attornment by Landlord to Subtenant or by Subtenant to Landlord in the absence of a specific written agreement signed by Landlord
to such effect, (ii be deemed a waiver by Landlord of any provision of the Lease, or (iii) serve to release Tenant from any liability under the terms, covenants, conditions, provisions or agreements under the Lease. Notwithstanding the foregoing,
within thirty (30) days following collection by Landlord of any rents or other sums from Subtenant pursuant to this Section 3.1, Landlord shall credit the amount thereof 
  

 -2- 

 against Tenant’s rental obligations under the Lease (including any Sublease profit calculated pursuant to the
provisions of Section 20 of the Office Lease) next coming after the date of such credit. Notwithstanding anything to the contrary contained herein, in no event shall Landlord be liable to Tenant in any manner whatsoever or under any circumstances
whatsoever for any failure by Landlord to collect any rents or any other sums from Subtenant under the Sublease. 
  
 3.2 Landlord’s Election of Subtenant’s Attornment. In the event Landlord elects, at its option, to cause Subtenant to attorn to Landlord
pursuant to item (iii) of Section 3, above, Landlord shall undertake the obligations of Tenant under the Sublease from the time of the exercise of the option, but Landlord shall not (i) be liable for any prepayment of more than one month’s rent
or any security deposit paid by Subtenant, (ii) be liable for any previous act or omission of Tenant under the Lease or for any other defaults of Tenant under the Sublease, (iii) be subject to any defenses or offsets previously accrued which
Subtenant may have against Tenant, or (iv) be bound by any changes or modifications made to the Sublease without the written consent of Landlord. 
  
 4. General Provisions. 
  
 4.1 Consideration for Sublease. Tenant and Subtenant represent and warrant that there are no additional payments of rent or any other consideration
of any type payable by Subtenant to Tenant with regard to the Sublet Premises other than as disclosed in the Sublease. 
  
 4.2 Brokerage Commission. Tenant and Subtenant covenant and agree that under no circumstances shall Landlord be liable for, any brokerage
commission or other charge or expense in connection with the Sublease and Tenant and Subtenant agree to protect, defend, indemnify and hold Landlord harmless from the same and from any cost or expense (including but not limited to attorneys’
fees) incurred by Landlord in resisting any claim for any such brokerage commission. 
  
 4.3 Landlord’s Rights Regarding Future Transfers. This consent shall in no manner be construed as limiting Landlord’s ability to exercise its rights to terminate the Lease in accordance with the
provisions of Section 20.2 of the Office Lease. 
  
 4.4
Controlling Law. The terms and provisions of this Agreement shall be construed in accordance with and governed by the laws of the State of California. 
  
 4.5 Binding Effect. This Agreement shall be binding upon and inure to the benefit of the parties hereto, their heirs, successors and assigns. As
used herein, the singular number includes the plural and the masculine gender includes the feminine and neuter. 
  
 4.6 Captions. The paragraph captions utilized herein are in no way intended to interpret or limit the terms and conditions hereof; rather they are
intended for purposes of convenience only. 
  
 4.7 Partial
Invalidity. If any term, provision or condition contained in this Agreement shall, to any extent, be invalid or unenforceable, the remainder of this Agreement, or the 
  

 -3- 

 application of such term, provision or condition to persons or circumstances other than those with respect to which it is
invalid or unenforceable, shall not be affected thereby, and each and every other term, provision and condition of this Agreement shall be valid and enforceable to the fullest extent possible permitted by law. 
  
 4.8 Attorneys’ Fees. If either party commences litigation against
the other for the specific performance of this Agreement, for damages for the breach hereof or otherwise for enforcement of any remedy hereunder, the parties hereto agree to and hereby do waive any right to a trial by jury and, in the event of any
such commencement of litigation, the prevailing party shall be entitled to recover from the other party such costs and reasonable attorneys’ fees as may have been incurred. 
  
 4.9 Reimbursement by Tenant. In accordance with the provisions of Section 20.7 of the Office Lease, concurrently upon
execution of this Agreement, Tenant shall pay to Landlord the amount of $875.00 for all reasonable attorneys’ fees and other costs incurred by Landlord in connection with the Sublease and the granting of Landlord’s consent thereto pursuant
to this Agreement. 
  
 IN WITNESS WHEREOF, the parties have
executed this Consent to Sublease Agreement as of the day and year first above written. 
  

	“Landlord”:	 	 	 	“Tenant”:
			
	GATEWAY CENTER LLC,	 	 	 	ELAN PHARMACEUTICALS, INC.,
	a Delaware limited liability company	 	 	 	a Delaware corporation
					
	By:	 	 Boston Properties Limited Partnership,
 A Delaware limited partnership,
 its sole member
	 	 	 	By:	  	 /S/    DAVID
HURLEY        

	 	 	 	 	 	Name:	  	 David Hurley

	 	 	 	 	 	Title:	  	 CFO

					
	By:	 	 Boston Properties, Inc.
 A
Delaware limited partnership,
 its general partner
	 	 	 	By:	  	  

	 	 	 	 	 	Name:	  	  

	 	 	 	 	 	Title:	  	  

				
	 	 	 	 	 	 	“Subtenant”:
	By:	 	 /S/    BOB
PESTER        

	 	 	 	 
	 	 	Bob Pester	 	 	 	TERCICA MEDICA, INC.
	 	 	Senior Vice President and	 	 	 	A Delaware corporation
	 	 	Regional Manager	 	 	 	 	  	 
	 	 	 	 	 	 	By:	  	 /S/    HOWARD
MOORE        

	 	 	 	 	 	 	Name:	  	 Howard S. Moore

	 	 	 	 	 	 	Title:	  	 Executive Vice President

					
	 	 	 	 	 	 	By:	  	  

	 	 	 	 	 	 	Name:	  	  

	 	 	 	 	 	 	Title:	  	  

  
  

 -4- 

 EXHIBIT A 
  
 THE SUBLEASE 
  

 -1-

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