Document:

MAP Pharmaceuticals, Inc. 2004 Long-Term Equity Incentive Plan

 EXHIBIT 10.1 

	
	  
 MAP PHARMACEUTICALS, INC.
 2004 LONG-TERM INCENTIVE PLAN
  

 1.        Definitions. In this Plan, except where
the context otherwise indicates, the following definitions shall apply: 
   1.1    “Affiliate” means
a corporation or other entity at least fifty percent (50%) of the total combined voting power of all classes of stock of which is owned by the Company (or any successor thereto), either directly or through one or more other Affiliates.

   1.2    “Agreement” means a written agreement evidencing an Award. 
   1.3    “Award” means a grant of an Option, Right or Performance Award or an award of Restricted Stock or
Incentive Shares. 
   1.4    “Board” means the Board of Directors of the Company. 
   1.5    “Code” means the Internal Revenue Code of 1986, as amended. 
   1.6    “Committee” means a committee or subcommittee of the Board appointed by the Board to administer this
Plan or to make and/or administer specific Awards under this Plan. If no such appointment is in effect at any time, “Committee” shall mean the Board. 
   1.7    “Common Stock” means the common stock, par value $.01 per share, of the Company. 
   1.8    “Company” means MAP Pharmaceuticals, Inc., a Delaware corporation. 
   1.9    “Date of Exercise” means the date on which the Company receives notice of the exercise of an Option in accordance with the terms of Section 8.1 of this Plan. 
   1.10    “Date of Grant” means the date on which an Option, Right or Performance Award is granted or Restricted
Stock or Incentive Shares are awarded under this Plan. 
   1.11    “Eligible Person” means
(a) any person who is an Employee, (b) any person who is hired to be an Employee, (c) any Non-Employee Director, and (d) any consultant, advisor or independent contractor to the Company or an Affiliate who is determined by the
Committee to render key services to the Company or an Affiliate. 
   1.12    “Employee” means any
person determined by the Committee to be an employee of the Company or an Affiliate. 
   1.13    “Exchange Act” means the Securities Exchange Act of 1934, as amended. 
  

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   1.14    “Fair Market Value” means an amount equal to the then
fair market value of a Share as determined by the Committee pursuant to a reasonable method adopted in good faith for such purpose, or, unless otherwise determined by the Committee, if the Shares become registered under the Securities Act of 1933,
as amended, and the Shares are traded on a securities exchange or automated interdealer quotation system, fair market value shall be the last sale price for a Share on such securities exchange or automated dealer quotation system as reported by such
source as the Committee may select. 
   1.15    “Incentive Shares” means an award providing for the
contingent grant of Shares pursuant to the provisions of Section 10 of this Plan. 
   1.16    “Incentive Stock Option” means an Option granted under this Plan that the Company designates as an incentive stock option under Section 422 of the Code. 
   1.17    “Non-Employee Director” means any member of the Company’s or an Affiliate’s Board of
Directors or Advisory Board (if any) who is not an Employee. 
   1.18    “Nonstatutory Stock Option”
means an Option granted under this Plan that is not an Incentive Stock Option. 
   1.19    “Option”
means an option to purchase Shares granted under this Plan in accordance with the terms of Section 6 of this Plan. 
   1.20    “Option Period” means the period during which an Option may be exercised. 
   1.21    “Option Price” means the price per Share at which an Option may be exercised. 
   1.22    “Participant” means an Eligible Person who has received an Award hereunder. 
   1.23    “Performance Award” means a performance award granted under this Plan in accordance with the terms of Section 11 of this Plan. 
   1.24    “Performance Goals” means performance goals established by the Committee, which may be based on
earnings or earnings growth, development or licensing milestones, sales, return on assets, cash flow, total shareholder return, equity or investment, regulatory compliance, satisfactory internal or external audits, improvement of financial ratings,
achievement of balance sheet or income statement objectives, or any other objective goals established by the Committee, and may be absolute in their terms or measured against or in relationship to other companies comparably, similarly or otherwise
situated. Such performance standards may be particular to an Eligible Person or the department, branch, Affiliate or other division in which he or she works, or may be based on the performance of the Company generally, and may cover such period as
may be specified by the Committee. 
   1.25    “Plan” means the MAP Pharmaceuticals, Inc. 2004
Long-Term Incentive Plan, as amended from time to time. 
  

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 1.26     “Related Option” means an Option in connection with which, or by
amendment to which, a specified Right is granted. 
 1.27     “Related Right” means a Right granted in
connection with, or by amendment to, a specified Option. 
 1.28     “Restricted Stock” means Shares awarded
under this Plan pursuant to the provisions of Section 9 of this Plan. 
 1.29     “Right” means a stock
appreciation right granted under this Plan in accordance with the terms of Section 7 of this Plan. 
 1.30
    “Right Period” means the period during which a Right may be exercised. 
 1.31
    “Share” means a share of Common Stock. 
 1.32     “Ten-Percent Stockholder”
means a Participant who (applying the rules of Section 424(d) of the Code) owns stock possessing more than ten percent (10%) of the total combined voting power of all classes of stock of the Company or an Affiliate. 
 2.     Purpose. This Plan is intended to assist the Company and its Affiliates in attracting and retaining Eligible Persons of
outstanding ability and to promote the identification of their interests with those of the stockholders of the Company and its Affiliates. 
 3.     Administration. The Committee shall administer this Plan and shall have plenary authority, in its discretion, to award Options, Rights, Restricted Stock, Incentive Shares and Performance Awards to Eligible
Persons, subject to the provisions of this Plan. The Committee shall have plenary authority and discretion, subject to the provisions of this Plan, to determine the Eligible Persons to whom Options, Rights or Performance Awards shall be granted and
to whom Restricted Stock or Incentive Shares shall be awarded, the terms (which terms need not be identical) of all Awards to Eligible Persons, including, without limitation, the Option Price of Options, the time or times at which Awards are made,
the number of Shares covered by Awards, whether an Option shall be an Incentive Stock Option or a Nonstatutory Stock Option, any exceptions to non-transferability, any Performance Goals applicable to Awards, any provisions relating to vesting, and
the period during which Options and Rights may be exercised and Restricted Stock shall be subject to restrictions. In making these determinations, the Committee may take into account the nature of the services rendered or to be rendered by the
Participant, their present and potential contributions to the success of the Company and its Affiliates, and such other factors as the Committee in its discretion shall deem relevant. Subject to the provisions of the Plan, the Committee shall have
plenary authority to interpret the Plan, prescribe, amend and rescind rules and regulations relating to it, and make all other determinations deemed necessary or advisable for the administration of this Plan. The determinations of the Committee on
the matters associated with the Plan, including the matters referred to in this Section 3, shall be binding and final. 
  

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 4.      Eligibility. 
 4.1    Options, Rights, Restricted Stock, Incentive Shares and Performance Awards may be granted or awarded only to Eligible Persons.

 4.2    Incentive Stock Options may only be issued to Employees. Incentive Stock Options may be granted to officers or
directors of the Company or an Affiliate, provided they are also Employees of the Company or an Affiliate. Payment of a director’s fee shall not be sufficient to constitute employment by the Company or an Affiliate. Incentive Stock Options
shall not be granted under this Plan to any Employee if such grant would result in such Employee holding the right to exercise for the first time in any one calendar year, under all Incentive Stock Options granted under this Plan or any other plan
maintained by the Company, with respect to Shares having an aggregate fair market value, determined as of the date the Option is granted, in excess of $100,000. Should it be determined that an Incentive Stock Option granted under this Plan exceeds
such maximum for any reason other than a failure in good faith to value the Shares subject to such option, the excess portion of such option shall be considered a Nonstatutory Stock Option. To the extent the Employee holds two (2) or more such
Options which become exercisable for the first time in the same calendar year, the foregoing limitation on the exercisability of such Options as Incentive Stock Options under the Federal tax laws shall be applied on the basis of the order in which
such Options are granted. If, for any reason, an entire Option does not qualify as an Incentive Stock Option by reason of exceeding such maximum, such Option, to the extent it exceeds the maximum, shall be considered a Nonstatutory Stock Option.

 5.      Stock Subject to Plan. 
 5.1      Subject to adjustment as provided in Section 12 of this Plan, the maximum number of Shares that may be issued under
this Plan or pursuant to Awards made under this Plan is twenty thousand eight hundred (20,800) Shares (including Shares that serve as the basis for determining Rights). 
 5.2      If an Option or Right expires or terminates for any reason (other than termination by virtue of the exercise of a Related
Option or Related Right, as the case may be) without having been fully exercised, if Shares of Restricted Stock are forfeited or if Shares covered by an Incentive Share Award or Performance Award are not issued or are forfeited, the unissued or
forfeited Shares which had been subject to the Award shall become available for the grant of additional Awards. In no event shall Shares which, under this Plan, are authorized to be used in payment of Incentive Shares or Performance Awards be deemed
to be unavailable for purposes of the Plan until such Shares have been issued in payment thereof in accordance with the provisions of Sections 10 and 11 of this Plan. 
 5.3      Upon exercise of a Right, the number of Shares with respect to which the Right is exercised shall be charged against the number of Shares issuable under this Plan and shall not become
available for the grant of other Awards (subject to Section 5.4). 
  

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 5.4     If any Shares are withheld or applied as payment by the Company in connection
with the exercise of an Option or the withholding of taxes related any Award, such Shares shall again be available under the Plan. 
 6.
     Options. 
 6.1     Options granted under this Plan to Eligible Persons shall be
either Incentive Stock Options or Nonstatutory Stock Options, as designated by the Committee; provided, however, that Incentive Stock Options may only be granted to Eligible Persons who are Employees. Each Option granted under this Plan shall be
clearly identified either as a Nonstatutory Stock Option or an Incentive Stock Option and shall be evidenced by an Agreement that specifies the terms and conditions of the grant. Options shall be subject to the terms and conditions set forth in this
Plan and such other terms and conditions not inconsistent with this Plan as the Committee may specify. 
 6.2     The
Option Price shall be determined by the Committee, subject to this Section 6.2. The Option Price for an Incentive Stock Option shall not be less than one hundred percent (100%) of the Fair Market Value of the Common Stock on the Date of
Grant. Notwithstanding the foregoing, in the case of an Incentive Stock Option granted to a Participant who is a Ten Percent Shareholder, the Option Price shall not be less than one hundred and ten percent (110%) of the Fair Market Value of the
Common Stock on the date on which the Option is granted. The Option Price for Nonstatutory Stock Options shall not be less than that permissible under applicable law, including, without limitation, the securities laws of the State of California as
they apply to exemptions from registration for Options granted to residents of California. 
 6.3     The Option Period
shall be determined by the Committee and specifically set forth in the Agreement; provided, however, that an Option shall not be exercisable after ten (10) years (five (5) years in the case of an Incentive Stock Option granted to a Ten
Percent Stockholder) from its Date of Grant. 
 6.4     The Committee may, in its sole discretion, require as a condition
to the issuance of Shares upon exercise of an Option under this Plan, that a Participant execute an agreement with the Company, in form and substance satisfactory to the Committee in its sole discretion restricting the Participant’s right to
transfer such Shares without first offering such Shares to the Company and/or one or more other stockholders of the Company upon the same terms and conditions as the proposed transfer. 
 7.      Rights. 
 7.1     Rights granted under this Plan shall be evidenced by an Agreement specifying the terms and conditions of the grant. 
 7.2     A Right may be granted under this Plan: (a) in connection with, and at the same time as, the grant of an Option under this Plan; (b) by amendment of an outstanding Option granted
under this Plan; or (c) independently of any Option granted under this Plan. A Right described in clause (a) or (b) of the preceding sentence is a Related Right. A Related Right may, in the Committee’s discretion, apply to all or
any portion of the Shares subject to the Related Option. 
  

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 7.3     A Right may be exercised in whole or in part as provided in the applicable
Agreement, and, subject to the terms of the Agreement, entitles a Participant to receive, without payment to the Company (but subject to required tax withholding), either cash or that number of Shares (equal to the highest whole number of Shares),
or a combination thereof, in an amount or having a Fair Market Value determined as of the Date of Exercise equal to the number of Shares subject to the portion of the Right exercised multiplied by an amount equal to the excess of (a) their Fair
Market Value on the Date of Exercise (or such amount in excess of such Fair Market Value as may be specified by the Committee) over (b) either (i) the Fair Market Value on the Date of Grant of the Right if it is not a Related Right, or
(ii) the Option Price as provided in the Related Option if the Right is a Related Right. 
 7.4     The Right Period
shall be determined by the Committee and specifically set forth in the Agreement; provided, however, that a Right will expire no later than the earlier of (i) ten (10) years from the Date of Grant, or (ii) in the case of a Related
Right, the expiration of the Related Option; and a Right that is a Related Right to an Incentive Stock Option may be exercised only when and to the extent the Related Option is exercisable. 
 7.5     The exercise, in whole or in part, of a Related Right shall cause a reduction in the number of Shares subject to the Related
Option equal to the number of Shares with respect to which the Related Right is exercised. Similarly, the exercise, in whole or in part, of a Related Option shall cause a reduction in the number of Shares subject to the Related Right equal to the
number of Shares with respect to which the Related Option is exercised. 
 8.      Exercise of Options and
Rights. 
 8.1     An Option or Right may, subject to the terms of the applicable Agreement under which it was
granted, be exercised in whole or in part by the delivery to the Company of written notice of the exercise, in such form as the Committee may prescribe, accompanied, in the case of an Option, by full payment for the Shares with respect to which the
Option is exercised made by cash, personal check or wire transfer, or with the permission of the Committee, by any one or more of the following means (which may be combined with any of the cash methods of payment): (a) delivery (including
constructive delivery) to the Company of Shares valued at their Fair Market Value on the Date of Exercise; (b) an irrevocable exercise notice and irrevocable instructions (in a form acceptable to the Board of Directors) to a registered
securities broker approved by the Board of Directors to sell Shares acquired through the exercise of the Option and promptly deliver cash to the Company in an amount equal to the aggregate Option Price; (c) with respect to Nonstatutory Stock
Options only, a promissory note as provided in Section 8.2 of this Plan; or (d) with respect to Nonstatutory Stock Options only, the surrender to the Company of the Option (or portion thereof) that has become exercisable and the receipt
from the Company upon such surrender, without any payment to the Company (other than required tax withholding amounts) of (i) that dumber of Shares (equal to the highest whole number of Shares) whose aggregate Fair Market Value as of the date
of surrender is equal to the amount by which the Fair Market Value of the Shares exercisable under the Option (or portion thereof) exceeds the aggregate Option Price of such Shares exercisable under the Option (or portion thereof), plus (ii) an
amount of cash equal to the Fair Market Value of any fractional Share to which the Participant is entitled. 
  

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 8.2     To the extent provided in an Agreement and permitted by applicable law, the
Committee may accept as partial payment of the Option Price for a Nonstatutory Stock Option a promissory note executed by the Participant evidencing his or her obligation to make future cash payment thereof. Promissory notes made pursuant to this
Section 8.2 shall be payable upon such terms as may be determined by the Committee, shall be secured by a pledge of the Shares received upon exercise of the Option, or other securities the Committee may deem to be acceptable for such purposes,
and shall bear interest at a rate fixed by the Committee. 
 8.3     Options and Rights granted under this Plan shall not
be transferable except by will, the laws of descent and distribution, or as provided by the Committee in an Agreement. 
 8.4
    The Company shall not be required to issue or deliver any certificate for Shares purchased upon the exercise of an Option granted hereunder or any portion thereof prior to fulfillment of all of the following conditions
(unless waived by the Committee): 
 (a)     the completion of any registration or other qualification of
such Shares under any federal or state law or under the rulings or regulations of the SecXurities and Exchange Commission or any other governmental regulatory body, which the Board shall in its sole discretion deem necessary or advisable;

 (b)    the obtaining of any approval or other clearance from any federal or state governmental agency
which the Board shall in its sole discretion determine to be necessary or advisable; 
 (c)     the lapse
of such reasonable period of time following the exercise of the Option as the Board from time to time may establish for reasons of administrative convenience; 
 (d)     the compliance with any and all applicable federal, state or local laws; 
 (e)     the execution by the recipient of the Shares of any Stockholder’s Agreement among the Company and its
stockholders that may then be in effect; and 
 (f)     such other terms and conditions as may be set
forth in the Agreement. 
 The Company shall further be entitled to place whatever legends on such certificate as it shall deem reasonably necessary or
appropriate. 
 9.      Restricted Stock Awards. 
 9.1     Restricted Stock awards, under this Plan shall consist of Shares that are restricted against transfer, subject to forfeiture,
and subject to such other terms and conditions as may be determined by the Committee. Such terms and conditions may provide, in the discretion of the Committee, for the vesting of such awards to be contingent upon the achievement of one or more
specified Performance Goals. 
  

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 9.2     Restricted Stock awards under this Plan shall be evidenced by Agreements
specifying the terms and conditions of the Award. Each Agreement evidencing an Award of Restricted Stock shall contain the following: 
 (a)     prohibitions against the sale, assignment, transfer, exchange, pledge, hypothecation, or other encumbrance of (i) the Shares awarded as Restricted Stock under this Plan, (ii) the
right to vote the Shares, and (iii) the right to receive dividends thereon, in each case during, the restriction period applicable to the Shares; provided, however, that the Participant shall have all the other rights of a stockholder
including, without limitation, the right to receive dividends and the right to vote the Shares; 
 (b)
    a requirement that each certificate representing Shares of Restricted Stock shall be deposited with the Company, or its designee, and shall bear the following legend: 
 “This certificate and the shares of stock represented hereby are subject to the terms and conditions (including the risks of forfeiture and
restrictions against transfer) contained in the MAP Pharmaceuticals, Inc. 2004 Long-Term Incentive Plan (the “Plan”), and an Agreement entered into between the registered owner and MAP Pharmaceuticals, Inc. Release from such terms and
conditions shall be made only in accordance with the provisions of the Plan and the Agreement, a copy of each of which is on file in the office of the Secretary of MAP Pharmaceuticals, Inc.” 
 (c)     the terms and conditions upon which any restrictions applicable to Shares of Restricted Stock shall lapse and
new certificates free of the foregoing legend shall be issued to the Participant or his or her legal representative; and 
 (d)     such other terms, conditions and restrictions as the Committee in its discretion may specify, including, without limitation, terms that condition the lapse of forfeiture and transfer restrictions upon the
achievement of Performance Goals. 
 9.3     The Committee may, in its sole discretion, require as a condition to the
award of Restricted Stock under this Plan, that a Participant execute an agreement with the Company, in form and substance satisfactory to the Committee, in its sole discretion, restricting the Participant’s right to transfer such Restricted
Stock after the restrictions against transfer and risk of forfeiture applicable thereto have lapsed without first offering such Shares to the Company and/or one or more other stockholders of the Company upon the same terms and conditions as the
proposed transfer. Without limiting the foregoing, the Committee may also require that the person to whom the Restricted Stock is issued execute any Stockholders’ Agreement among the Company and its stockholders that may then be in effect.

  

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 10.      Incentive Share Awards. Incentive Shares awarded under this Plan
shall be evidenced by an Agreement specifying the terms and conditions of such Award. Incentive Share Awards shall provide for the issuance of Shares to a Participant at such times and subject to such terms and conditions as determined by the
Committee, including, without limitation, terms that condition the issuance of Shares upon the achievement of Performance Goals. 
 11.
     Performance Awards. Performance Awards granted under this Plan shall be evidenced by an Agreement specifying the terms and conditions of such Award. Performance Awards shall become payable on account of
attainment of one or more Performance Goals established by the Committee. Performance Awards may be paid by the delivery of Shares or cash, or any combination of Shares and cash, as specified in the Agreement. If a Performance Award is paid in cash,
the Award shall be deemed, for purposes of Section 5.1 of this Plan, to cover a number of Shares equal to the quotient obtained by dividing the dollar amount of the Award payment by the Fair Market Value of a Share as of the date of payment,
rounded to the next highest whole number. 
 12.      Capital Adjustments. In the event of any change in the
outstanding Common Stock by reason of any stock dividend, stock split, reverse stock split, recapitalization, reclassification, combination, reorganization or exchange of shares, merger, consolidation or liquidation and the like, the Committee may,
in its discretion, provide for a substitution for or adjustment in (a) the number and class of Shares subject to outstanding Options, Rights and Awards of Restricted Stock, Incentive Shares or Performance Awards, (b) the Option Price of
Options and the base price upon which payments under Rights that are not Related Rights are determined, and (c) the aggregate number and class of Shares for which Awards thereafter may be made under this Plan and to individual Award recipients.
No adjustment shall be made for dividends (ordinary or extraordinary, whether in cash, securities or other property) or distributions or other rights for which the record date is prior to the date such Option is exercised and a stock certificate for
said Common Stock is issued, except as provided above in this Section 12. 
 13.      Termination or
Amendment. The Board may amend, alter or terminate this Plan in any respect at any time; provided, however, that, after this Plan has been approved by the stockholders of the Company, no amendment, alteration or termination of this Plan shall be
made by the Board without approval of (a) the Company’s stockholders to the extent stockholder approval of the amendment is required by applicable law or regulations or the requirements of the securities exchange or automated interdealer
quotation system on which the Common Stock is listed or quoted, if any, and (b) each affected Participant if such amendment, alteration or termination would adversely affect his or her rights or obligations under any Award made prior to the
date of such amendment, alteration or termination. 
 14.      Modification, Extension, Renewal,
Substitution. 
 14.1     Subject to the terms and conditions of this Plan, the Committee may modify, extend or renew
outstanding Options and Rights, or accept the surrender of outstanding Options and Rights granted under this Plan or options and stock appreciation rights granted under any other plan of the Company or an Affiliate (to the extent not theretofore
exercised), and authorize the granting of new Options and Rights pursuant to this Plan in substitution therefor. 

  

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Any substituted Options or Rights may specify a lower exercise price than the surrendered options and stock appreciation rights, a longer term than the
surrendered options and stock appreciation rights, or have any other provisions that are authorized by this Plan. Subject to the terms and conditions of this Plan, the Committee may modify the terms of any outstanding Awards. Notwithstanding the
foregoing, however, no modification of an Award shall, without the consent of the Participant, alter or impair any of the Participant’s rights or obligations under such Award, except for (i) alterations and modifications expressly
permitted to be made by this Plan or the applicable Agreement, and (ii) alterations or modifications which do not have a material adverse effect on the Award and the Agreement. 
 14.2     Anything contained herein to the contrary notwithstanding, Options, Rights, Restricted Stock, Incentive Shares and
Performance Awards may, at the discretion of the Committee, be granted under this Plan in substitution for options and such other awards covering capital stock of another corporation which is merged into, consolidated with, or all or a substantial
portion of the property or stock of which is acquired by, the Company or one of its Affiliates. The terms and conditions of the substitute Awards so granted may vary from the terms and conditions set forth in this Plan to such extent as the
Committee may deem appropriate in order to conform, in whole or part, to the provisions of the awards in substitution for which they are granted. Such substitute Awards granted hereunder shall not be counted toward the Share limit imposed by
Section 5.1 of this Plan, except to the extent it is determined by the Committee that counting such Awards is required in order for grants of Options and Rights hereunder to be eligible to qualify as “performance-based compensation”
within the meaning of Section 162(m) of the Code. 
 15.     Effectiveness of this Plan. This Plan and any
amendments to this Plan requiring stockholder approval pursuant to Section 13 of this Plan are subject to approval by the vote of the stockholders of the Company at the next annual or special meeting of stockholders following adoption by the
Board. Subject to such stockholder approval, this Plan and any amendments to this Plan are effective on the date on which they are adopted by the Board or such other date as may be specified by the Board. 
 16.     Withholding. The Company’s obligation to deliver Shares or pay any amount pursuant to the terms of any Award
hereunder shall, be subject to satisfaction of applicable federal, state and local tax withholding requirements. To the extent provided in the applicable Agreement and in accordance with rules prescribed by the Committee, a Participant may satisfy
any such withholding tax obligation by any of the following means or by a combination of such means: (a) tendering a cash payment; (b) authorizing the Company to withhold Shares otherwise issuable to the Participant; or (c) delivering
to the Company already owned and unencumbered Shares. 
 17.     Notification under Code Section 83(b). If a
Participant, in connection with any exercise of an Option, or the grant of Restricted Shares, makes the election permitted under Section 83(b) of the Code to include in such Participant’s gross income in the year of transfer the amounts
specified in Section 83(b) of the Code, then such Participant shall notify the Company of such election within 10 days of filing the notice of the election with the Internal Revenue Service, in addition to filing any notification required
pursuant to regulation issued under Section 83(b) of the Code. The Committee may, in connection with the grant of an Award or at any time thereafter prior to such an election being made, prohibit a Participant from making such election.

  

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 18.      Term of this Plan. Unless sooner terminated by the Board
pursuant to Section 13 of this Plan, this Plan shall terminate on February l, 2014, and no Awards may be granted or awarded after such date. The termination of this Plan shall not affect the validity of any Award outstanding on the date of
termination and shall not affect the terms and conditions of this Plan as they apply to any such outstanding Awards. 
 19.
     Indemnification of Committee. In addition to such other rights of indemnification as they may have as Directors or as members of the Committee, the members of the Committee shall be indemnified by the Company
against all reasonable expenses, including attorneys’ fees, actually and reasonably incurred in connection with the defense of any action, suit or proceeding, or in connection with any appeal therein, to which they or any of them may be a party
by reason of any action taken or failure to act under or in connection with this Plan or any Option, Right, Restricted Stock, Incentive Shares or Performance Awards granted or awarded under this Plan, and against all amounts reasonably paid by them
in settlement thereof or paid by them in satisfaction of a judgment in any such action, suit or proceeding, if such members acted in good faith and in a manner which they believed to be in, and not opposed to, the best interests of the Company.

 20.     General Provisions. 
 20.1     The establishment of this Plan shall not confer upon any Eligible Person any legal or equitable right against the Company, any Affiliate or the Committee, except as expressly provided in
this Plan. 
 20.2     This Plan does not constitute inducement or consideration for the employment or service of any
Eligible Person, nor is it a contract between the Company or any Affiliate and any Eligible Person. Participation in this Plan shall not give an Eligible Person any right to be retained in the service of the Company or any Affiliate. 
 20.3     Neither the adoption of this Plan nor its submission to the stockholders, shall be taken to impose any limitations on the
powers of the Company or its Affiliates to issue, grant, or assume options, warrants, rights, or restricted stock, or other awards otherwise than under this Plan, or to adopt other stock option, restricted stock, or other plans or to impose any
requirement of stockholder approval upon the same. 
 20.4     The interests of any Eligible Person under this Plan are
not subject to the claims of creditors and may not, in any way, be assigned, alienated or encumbered except as provided in the applicable Agreement. 
 20.5     This Plan shall be governed, construed and administered in accordance with the laws of the State of Delaware, without regard to conflicts of law principles. 
 20.6     The adoption of the Plan shall not affect any other stock option or incentive or other compensation plans in effect for the
Company or any of its subsidiaries, nor shall the Plan preclude the Company from establishing any other forms of stock option plans or 

  

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incentive or other compensation plans for employees, officers, directors, consultants or advisors of the Company or any of its subsidiaries. 
 20.7     During any period in which the Company has a class of equity securities registered under Section 12 of the Exchange
Act, and with respect to persons subject to Section 16 of the Exchange Act, transactions under this Plan are intended to comply with all applicable provisions of Section 16 of the Exchange Act and the rules promulgated thereunder
(including without limitation, Rule 16b-3) or their successors under the Exchange Act. During any period in which the Company has a class of equity securities registered under Section 12 of the Exchange Act, to the extent any provision of the
Plan or any Agreement or any action by the Board or the Committee fails to so comply, it shall be deemed null and void, to the extent permitted by law and deemed advisable by the Board or the Committee, and it shall be restructured to the extent
deemed advisable by the Board so to comply. By accepting Awards granted under the Plan, a Participant shall be deemed to have consented to any modifications to the Plan or any Agreement which the Board or Committee may deem desirable in order that
the Plan or any Agreement shall comply with Section 16 of the Exchange Act. 
 20.8     The Committee may require
each person acquiring Shares pursuant to Awards hereunder to represent to and agree with the Company in writing that such person is acquiring the Shares without a view to distribution thereof. The certificates for such Shares may include any legend
which the Committee deems appropriate to reflect any restrictions on transfer. All certificates for Shares issued pursuant to this Plan shall be subject to such stock transfer orders and other restrictions as the Committee may deem advisable under
the rules, regulations and other requirements of the Securities and Exchange Commission, any securities exchange upon which the Common Stock is then listed or automatic interdealer quotation system upon which the Common Stock is then quoted, and any
applicable federal or state securities laws. The Committee may place a legend or legends on any such certificates to make appropriate reference to such restrictions. 
 20.9     The Company shall not be required to issue any certificate or certificates for Shares with respect to Awards under this Plan, or record any person as a holder of record of such Shares;
without obtaining, to the complete satisfaction of the Committee, the approval of all regulatory bodies deemed necessary by the Committee, and without complying to the Board’s or Committee’s complete satisfaction, with all rules and
regulations, under federal, state or local law deemed applicable by the Committee. 
  

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 FIRST AMENDMENT 
 TO THE 
 MAP PHARMACEUTICALS, INC. 2004 LONG-TERM INCENTIVE PLAN 
 Section 5.1 of the MAP Pharmaceuticals, Inc. 2004 Long Term Incentive Plan (the “Plan”) is hereby amended to read in its entirety as
follows: 
 “5.1         Subject to adjustment as provided in Section 12 of this Plan,
the maximum aggregate number of Shares that may be issued under this Plan or pursuant to Awards made under this Plan is two hundred four thousand eight hundred (204,800). Shares (including Shares that serve as the basis for determining Rights), all
of which are eligible to be issued under the Plan through Incentive Stock Options.” 
 Except as amended above, the Plan shall
remain in full force and effect in accordance with its terms. 
 Adopted by the Board of Directors of MAP Pharmaceuticals, Inc. as of
August 12, 2004 and approved by the stockholders of MAP Pharmaceuticals, Inc. as of August 12, 2004. 
  
  

			
	MAP PHARMACEUTICALS, INC.
		
	By:	 	/s/ Thomas A. Armer
	Name:	 	Thomas A. Armer
	Title:	 	President and CSOMAP Pharmaceuticals, Inc. Amended and Restated 2005 Equity Incentive Plan

 EXHIBIT 10.2 
 MAP PHARMACEUTICALS, INC. 
 2005 EQUITY INCENTIVE PLAN 
 (Amended and Restated) 
 1.
        Purposes of the Plan. The purposes of the MAP Pharmaceuticals, Inc. 2005 Equity Incentive Plan are to attract and retain the best available personnel for positions of substantial responsibility,
to provide additional incentive to Employees, Directors and Consultants and to promote the success of the Company’s business. Options granted under the Plan may be Incentive Stock Options or Non-Qualified Stock Options, as determined by the
Administrator at the time of grant. Stock Purchase Rights may also be granted under the Plan. 
 2.
        Definitions. As used herein, the following definitions shall apply: 
   (a)
        “Acquisition” means (1) a dissolution, liquidation or sale of all or substantially all of the assets of the Company; (2) a merger or consolidation in which the Company is not
the surviving corporation; or (3) a reverse merger in which the Company is the surviving corporation but the shares of the Company’s common stock outstanding immediately preceding the merger are converted by virtue of the merger into other
property, whether in the form of securities, cash or otherwise. 
   (b)
        “Administrator” means the Board or the Committee responsible for conducting the general administration of the Plan, as applicable, in accordance with Section 4 hereof. 

  (c)         “Applicable Laws” means the requirements relating to the
administration of stock option plans under U.S. state corporate laws, U.S. federal and state securities laws, the Code, any stock exchange or quotation system on which the Common Stock is listed or quoted and the applicable laws of any foreign
country or jurisdiction where Options or Stock Purchase Rights are granted under the Plan. 
   (d)
        “Board” means the Board of Directors of the Company. 
   (e)
        “Code” means the Internal Revenue Code of 1986, as amended, or any successor statute or statutes thereto. Reference to any particular Code section shall include any successor section.

   (f)         “Committee” means a committee appointed by the Board in
accordance with Section 4 hereof. 
   (g)         “Common Stock”
means the Common Stock of the Company. 
   (h)         “Company” means
MAP Pharmaceuticals, Inc. a Delaware corporation. 
   (i)
        “Consultant” means any consultant or adviser if: (i) the consultant or adviser renders bona fide services to the Company or any Parent or Subsidiary of the Company; 

 
(ii) the services rendered by the consultant or adviser are not in connection with the offer or sale of securities in a capital-raising transaction and
do not directly or indirectly promote or maintain a market for the Company’s securities; and (iii) the consultant or adviser is a natural person who has contracted directly with the Company or any Parent or Subsidiary of the Company to
render such services. 
 (j)         “Director” means a member of the Board.

 (k)         “Employee” means any person, including an Officer or Director, who is
an employee (as defined in accordance with Section 3401(c) of the Code) of the Company or any Parent or Subsidiary of the Company. A Service Provider shall not cease to be an Employee in the case of (i) any leave of absence approved by the
Company or (ii) transfers between locations of the Company or between the Company, its Parent, any Subsidiary, or any successor. For purposes of Incentive Stock Options, no such leave may exceed ninety (90) days, unless reemployment upon
expiration of such leave is guaranteed by statute or contract. Neither service as a Director nor payment of a director’s fee by the Company shall be sufficient, by itself, to constitute “employment” by the Company. 
 (l)         “Exchange Act” means the Securities Exchange Act of 1934, as amended, or any
successor statute or statutes thereto. Reference to any particular Exchange Act section shall include any successor section. 
 (m)
        “Fair Market Value” means, as of any date, the value of a share of Common Stock determined as follows: 
     (i)         If the Common Stock is listed on any established stock exchange or a national market system, its Fair Market Value shall be the closing sales
price for a share of such stock (or the closing bid, if no sales were reported) as quoted on such exchange or system for the last market trading day prior to the time of determination, as reported in The Wall Street Journal or such other source as
the Administrator deems reliable; 
     (ii)         If the Common Stock is
regularly quoted by a recognized securities dealer but selling prices are not reported, its Fair Market Value shall be the mean between the high bid and low asked prices for a share of the Common Stock on the last market trading day prior to the day
of determination; or 
     (iii)         In the absence of an established
market for the Common Stock, the Fair Market Value thereof shall be determined in good faith by the Administrator. 
 (n)
        “Holder” means a person who has been granted or awarded an Option or Stock Purchase Right or who holds Shares acquired pursuant to the exercise of an Option or Stock Purchase Right.

 (o)         “Incentive Stock Option” means an Option intended to qualify as an
incentive stock option within the meaning of Section 422 of the Code and which is designated as an Incentive Stock Option by the Administrator. 

 (p)         “Independent Director” means a
Director who is not an Employee of the Company. 
 (q)         “Non-Qualified Stock
Option” means an Option (or portion thereof) that is not designated as an Incentive Stock Option by the Administrator, or which is designated as an Incentive Stock Option by the Administrator but fails to qualify as an incentive stock
option within the meaning of Section 422 of the Code. 
 (r)         “Officer”
means a person who is an officer of the Company within the meaning of Section 16 of the Exchange Act and the rules and regulations promulgated thereunder. 
 (s)         “Option” means a stock option granted pursuant to the Plan. 
 (t)         “Option Agreement” means a written agreement between the Company and a Holder evidencing the terms and conditions of an individual Option grant. The
Option Agreement is subject to the terms and conditions of the Plan. 
 (u)
        “Parent” means any corporation, whether now or hereafter existing (other than the Company), in an unbroken chain of corporations ending with the Company if each of the corporations
other than the last corporation in the unbroken chain owns stock possessing more than fifty percent of the total combined voting power of all classes of stock in one of the other corporations in such chain. 
 (v)         “Plan” means the MAP Pharmaceuticals, Inc. 2005 Equity Incentive Plan. 

(w)         “Public Trading Date” means the first date upon which Common Stock of the Company
is listed (or approved for listing) upon notice of issuance on any securities exchange or designated (or approved for designation) upon notice of issuance as a national market security on an interdealer quotation system. 
 (x)         “Restricted Stock” means Shares acquired pursuant to the exercise of an unvested
Option in accordance with Section 10(h) below or pursuant to a Stock Purchase Right granted under Section 12 below. 
 (y)
        “Rule 16b-3” means that certain Rule 16b-3 under the Exchange Act, as such Rule may be amended from time to time. 
 (z)         “Securities Act” means the Securities Act of 1933, as amended, or any successor
statute or statutes thereto. Reference to any particular Securities Act section shall include any successor section. 
 (aa)
      “Service Provider” means an Employee, Director or Consultant. 
 (bb)
      “Share” means a share of Common Stock, as adjusted in accordance with Section 13 below. 

 (cc)       “Stock Purchase Right” means a right to
purchase Common Stock pursuant to Section 12 below. 
 (dd)       “Subsidiary” means any
corporation, whether now or hereafter existing (other than the Company), in an unbroken chain of corporations beginning with the Company if each of the corporations other than the last corporation in the unbroken chain owns stock possessing more
than fifty percent of the total combined voting power of all classes of stock in one of the other corporations in such chain. 
 3.
        Stock Subject to the Plan. Subject to the provisions of Section 13 of the Plan, the shares of stock subject to Options or Stock Purchase Rights shall be Common Stock, initially shares of
the Company’s Common Stock. Subject to the provisions of Section 13 of the Plan, the maximum aggregate number of Shares which may be issued upon exercise of such Options or Stock Purchase Rights is 5,423,909 Shares. Shares issued upon
exercise of Options or Stock Purchase Rights may be authorized but unissued, or reacquired Common Stock. If an Option or Stock Purchase Right expires or becomes unexercisable without having been exercised in full, the unpurchased Shares which were
subject thereto shall become available for future grant or sale under the Plan (unless the Plan has terminated). Shares which are delivered by the Holder or withheld by the Company upon the exercise of an Option or Stock Purchase Right under the
Plan, in payment of the exercise price thereof or tax withholding thereon, may again be optioned, granted or awarded hereunder, subject to the limitations of this Section 3. If Shares of Restricted Stock are repurchased by the Company at their
original purchase price, such Shares shall become available for future grant under the Plan. Notwithstanding the provisions of this Section 3, no Shares may again be optioned, granted or awarded if such action would cause an Incentive Stock
Option to fail to qualify as an Incentive Stock Option under Section 422 of the Code. 
 4.        Administration of the Plan. 
   (a)
        Administrator. Unless and until the Board delegates administration to a Committee as set forth below, the Plan shall be administered by the Board. The Board may delegate administration of the
Plan to a Committee or Committees of one or more members of the Board, and the term “Committee” shall apply to any person or persons to whom such authority has been delegated. If administration is delegated to a Committee, the Committee
shall have, in connection with the administration of the Plan, the powers theretofore possessed by the Board, including the power to delegate to a subcommittee any of the administrative powers the Committee is authorized to exercise (and references
in this Plan to the Board shall thereafter be to the Committee or subcommittee), subject, however, to such resolutions, not inconsistent with the provisions of the Plan, as may be adopted from time to time by the Board. Notwithstanding the
foregoing, however, from and after the Public Trading Date, a Committee of the Board shall administer the Plan and the Committee shall consist solely of two or more Independent Directors each of whom is both an “outside director,” within
the meaning of Section 162(m) of the Code, and a “non-employee director” within the meaning of Rule 16b-3. Within the scope of such authority, the Board or the Committee may (i) delegate to a committee of one or more members of
the Board who are not Independent Directors the authority to grant awards under the Plan to eligible persons who are either (1) not then “covered employees,” within the meaning of Section 162(m) of the Code and are not expected
to be “covered employees” at the time of recognition of income resulting from such award or (2) not persons with respect to whom the Company wishes 

 
to comply with Section 162(m) of the Code and/or (ii) delegate to a committee of one or more members of the Board who are not “non-employee
directors,” within the meaning of Rule 16b-3, the authority to grant awards under the Plan to eligible persons who are not then subject to Section 16 of the Exchange Act. The Board may abolish the Committee at any time and revest in the
Board the administration of the Plan. Appointment of Committee members shall be effective upon acceptance of appointment. Committee members may resign at any time by delivering written notice to the Board. Vacancies in the Committee may only be
filled by the Board. 
 (b)         Powers of the Administrator. Subject to the provisions of
the Plan and the specific duties delegated by the Board to such Committee, and subject to the approval of any relevant authorities, the Administrator shall have the authority in its sole discretion: 
   (i)         to determine the Fair Market Value; 
   (ii)        to select the Service Providers to whom Options and Stock Purchase Rights may from time to
time be granted hereunder; 
   (iii)       to determine the number of Shares to be covered by each
such award granted hereunder; 
   (iv)       to approve forms of agreement for use under the Plan;

   (v)        to determine the terms and conditions of any Option or Stock Purchase Right
granted hereunder (such terms and conditions include, but are not limited to, the exercise price, the time or times when Options or Stock Purchase Rights may vest or be exercised (which may be based on performance criteria), any vesting acceleration
or waiver of forfeiture restrictions, and any restriction or limitation regarding any Option or Stock Purchase Right or the Common Stock relating thereto, based in each case on such factors as the Administrator, in its sole discretion, shall
determine); 
   (vi)        to determine whether to offer to buyout a previously granted
Option as provided in subsection 10(i) and to determine the terms and conditions of such offer and buyout (including whether payment is to be made in cash or Shares); 
   (vii)       to prescribe, amend and rescind rules and regulations relating to the Plan, including rules and
regulations relating to sub-plans established for the purpose of qualifying for preferred tax treatment under foreign tax laws; 
   (viii)      to allow Holders to satisfy withholding tax obligations by electing to have the Company withhold from the Shares to be issued upon exercise of an Option or Stock Purchase Right that number of
Shares having a Fair Market Value equal to the minimum amount required to be withheld based on the statutory withholding rates for federal and state tax purposes that apply to supplemental taxable income. The Fair Market Value of the Shares to be
withheld shall be determined on the date that the amount of tax to be withheld is to be determined. All elections by Holders to have Shares withheld for this purpose shall be made in such form and under such conditions as the Administrator may deem
necessary or advisable; 

     (ix)       to amend the Plan or any Option or
Stock Purchase Right granted under the Plan as provided in Section 15; and 
     (x)
        to construe and interpret the terms of the Plan and awards granted pursuant to the Plan and to exercise such powers and perform such acts as the Administrator deems necessary or desirable to promote
the best interests of the Company which are not in conflict with the provisions of the Plan. 
    (c)
        Effect of Administrator’s Decision. All decisions, determinations and interpretations of the Administrator shall be final and binding on all Holders. 
 5.         Eligibility. Non-Qualified Stock Options and Stock Purchase Rights may be granted to Service
Providers. Incentive Stock Options may be granted only to Employees. If otherwise eligible, an Employee or Consultant who has been granted an Option or Stock Purchase Right may be granted additional Options or Stock Purchase Rights. 
 6.         Limitations. 
    (a)         Each Option shall be designated by the Administrator in the Option Agreement as either an Incentive Stock Option or a Non-Qualified Stock Option.
However, notwithstanding such designations, to the extent that the aggregate Fair Market Value of Shares subject to a Holder’s Incentive Stock Options and other incentive stock options granted by the Company, any Parent or Subsidiary, which
become exercisable for the first time during any calendar year (under all plans of the Company or any Parent or Subsidiary) exceeds $100,000, such excess Options or other options shall be treated as Non-Qualified Stock Options. 
    For purposes of this Section 6(a), Incentive Stock Options shall be taken into account in the order in which they were granted,
and the Fair Market Value of the Shares shall be determined as of the time of grant. 
    (b)
        Neither the Plan, any Option nor any Stock Purchase Right shall confer upon a Holder any right with respect to continuing the Holder’s employment or consulting relationship with the Company, nor
shall they interfere in any way with the Holder’s right or the Company’s right to terminate such employment or consulting relationship at any time, with or without cause. 
    (c)         No Service Provider shall be granted, in any calendar year, Options or Stock
Purchase Rights to purchase more than 1,800,000 Shares; provided, however, that the foregoing limitation shall not apply prior to the Public Trading Date and, following the Public Trading Date, the foregoing limitation shall not apply until
the earliest of: (i) the first material modification of the Plan (including any increase in the number of shares reserved for issuance under the Plan in accordance with Section 3); (ii) the issuance of all of the shares of Common
Stock reserved for issuance under the Plan; (iii) the expiration of the Plan; (iv) the first meeting of stockholders at which Directors of the Company are to be elected that occurs after the close of the third calendar year following the
calendar year in which occurred the first registration of an equity security of the Company under Section 12 of the Exchange Act; or (v) such other date required by Section 162(m) of the Code and the rules and regulations promulgated
thereunder. The foregoing limitation shall be adjusted proportionately in connection with any change in the 

 
Company’s capitalization as described in Section 13. For purposes of this Section 6(c), if an Option is canceled in the same calendar year it
was granted (other than in connection with a transaction described in Section 13), the canceled Option will be counted against the limit set forth in this Section 6(c). For this purpose, if the exercise price of an Option is reduced, the
transaction shall be treated as a cancellation of the Option and the grant of a new Option. 
 7.
        Term of Plan. The Plan shall become effective upon its initial adoption by the Board and shall continue in effect until it is terminated under Section 15 of the Plan. No Options or Stock
Purchase Rights may be issued under the Plan after the tenth (10th) anniversary of the earlier of (i) the date upon which the Plan is adopted by the Board or (ii) the date the Plan is approved by the stockholders. 
 8.         Term of Option. The term of each Option shall be stated in the Option Agreement; provided,
however, that the term shall be no more than ten (10) years from the date of grant thereof. In the case of an Incentive Stock Option granted to a Holder who, at the time the Option is granted, owns (or is treated as owning under Code
Section 424) stock representing more than ten percent (10%) of the voting power of all classes of stock of the Company or any Parent or Subsidiary, the term of the Option shall be five (5) years from the date of grant or such shorter
term as may be provided in the Option Agreement. 
 9.         Option Exercise Price and
Consideration. 
    (a)         Except as provided in Section 13, the per
share exercise price for the Shares to be issued upon exercise of an Option shall be such price as is determined by the Administrator, but shall be subject to the following: 
       (i)         In the case of an Incentive Stock Option 
        (A)         granted to an Employee who, at the time of grant of such
Option, owns (or is treated as owning under Code Section 424) stock representing more than ten percent (10%) of the voting power of all classes of stock of the Company or any Parent or Subsidiary, the per Share exercise price shall be no
less than one hundred ten percent (110%) of the Fair Market Value per Share on the date of grant. 
        (B)         granted to any other Employee, the per Share exercise price shall be no less than one hundred percent (100%) of the Fair Market Value per
Share on the date of grant. 
       (ii)         In the case of a
Non-Qualified Stock Option 
        (A)         granted to a
Service Provider who, at the time of grant of such Option, owns stock representing more than ten percent (10%) of the voting power of all classes of stock of the Company or any Parent or Subsidiary, the exercise price shall be no less than one
hundred ten percent (110%) of the Fair Market Value per Share on the date of the grant. 
       (B)
        granted to any other Service Provider, the per Share exercise price shall be no less than eighty-five percent (85%) of the Fair Market Value per Share on the date of grant. 

     (iii)       Notwithstanding the foregoing, Options
may be granted with a per Share exercise price other than as required above pursuant to a merger or other corporate transaction. 
 (b)
        The consideration to be paid for the Shares to be issued upon exercise of an Option, including the method of payment, shall be determined by the Administrator (and, in the case of an Incentive Stock
Option, shall be determined at the time of grant). Such consideration may consist of (1) cash, (2) check, (3) with the consent of the Administrator, a full recourse promissory note bearing interest (at no less than such rate as shall
then preclude the imputation of interest under the Code) and payable upon such terms as may be prescribed by the Administrator, (4) with the consent of the Administrator, other Shares which (x) in the case of Shares acquired from the
Company, have been owned by the Holder for more than six (6) months on the date of surrender, and (y) have a Fair Market Value on the date of surrender equal to the aggregate exercise price of the Shares as to which such Option shall be
exercised, (5) with the consent of the Administrator, surrendered Shares then issuable upon exercise of the Option having a Fair Market Value on the date of exercise equal to the aggregate exercise price of the Option or exercised portion
thereof, (6) property of any kind which constitutes good and valuable consideration, (7) with the consent of the Administrator, delivery of a notice that the Holder has placed a market sell order with a broker with respect to Shares then
issuable upon exercise of the Options and that the broker has been directed to pay a sufficient portion of the net proceeds of the sale to the Company in satisfaction of the Option exercise price, provided, that payment of such proceeds is
then made to the Company upon settlement of such sale, or (8) with the consent of the Administrator, any combination of the foregoing methods of payment. 
 10.         Exercise of Option. 
      (a)         Vesting; Fractional Exercises. Except as provided in Section 13, Options granted hereunder shall be vested and exercisable according to the terms
hereof at such times and under such conditions as determined by the Administrator and set forth in the Option Agreement; provided, however, that, except with regard to Options granted to Officers, Directors or Consultants, in no event shall
an Option granted hereunder become vested and exercisable at a rate of less than twenty percent (20%) per year over five (5) years from the date the Option is granted, subject to reasonable conditions, such as continuing to be a Service
Provider. An Option may not be exercised for a fraction of a Share. 
      (b)
        Deliveries upon Exercise. All or a portion of an exercisable Option shall be deemed exercised upon delivery of all of the following to the Secretary of the Company or his or her office:

         (i)         A written or electronic notice
complying with the applicable rules established by the Administrator stating that the Option, or a portion thereof, is exercised. The notice shall be signed by the Holder or other person then entitled to exercise the Option or such portion of the
Option; 
         (ii)         Such representations and
documents as the Administrator, in its sole discretion, deems necessary or advisable to effect compliance with Applicable Laws. The Administrator may, in its sole discretion, also take whatever additional actions it deems 

 
appropriate to effect such compliance, including, without limitation, placing legends on share certificates and issuing stop transfer notices to agents and
registrars; 
     (iii)     Upon the exercise of all or a portion of an unvested Option pursuant to
Section 10(h), a Restricted Stock purchase agreement in a form determined by the Administrator and signed by the Holder or other person then entitled to exercise the Option or such portion of the Option; and 
     (iv)     In the event that the Option shall be exercised pursuant to Section 10(f) by any person or
persons other than the Holder, appropriate proof of the right of such person or persons to exercise the Option. 
 (c)
        Conditions to Delivery of Share Certificates. The Company shall not be required to issue or deliver any certificate or certificates for Shares purchased upon the exercise of any Option or
portion thereof prior to fulfillment of all of the following conditions: 
     (i)
        The admission of such Shares to listing on all stock exchanges on which such class of stock is then listed; 
     (ii)         The completion of any registration or other qualification of such Shares under any state or federal law, or under the rulings or regulations
of the Securities and Exchange Commission or any other governmental regulatory body which the Administrator shall, in its sole discretion, deem necessary or advisable; 
     (iii)         The obtaining of any approval or other clearance from any state or federal governmental agency which the Administrator shall, in its sole
discretion, determine to be necessary or advisable; 
     (iv)         The
lapse of such reasonable period of time following the exercise of the Option as the Administrator may establish from time to time for reasons of administrative convenience; and 
     (v)         The receipt by the Company of full payment for such Shares, including
payment of any applicable withholding tax, which in the sole discretion of the Administrator may be in the form of consideration used by the Holder to pay for such Shares under Section 9(b). 
 (d)        Termination of Relationship as a Service Provider. If a Holder ceases to be a Service Provider
other than by reason of the Holder’s disability or death, such Holder may exercise his or her Option within such period of time as is specified in the Option Agreement to the extent that the Option is vested on the date of termination;
provided, however, that prior to the Public Trading Date, such period of time shall not be less than thirty (30) days (but in no event later than the expiration of the term of the Option as set forth in the Option Agreement). In
the absence of a specified time in the Option Agreement, the Option shall remain exercisable for three (3) months following the Holder’s termination. If, on the date of termination, the Holder is not vested as to his or her entire Option,
the Shares covered by the unvested portion of the Option immediately cease to be issuable under the Option and shall again become available for issuance under the Plan. If, after termination, the Holder does not exercise his or her Option 

 
within the time period specified herein, the Option shall terminate, and the Shares covered by such Option shall again become available for issuance under
the Plan. 
 (e)        Disability of Holder. If a Holder ceases to be a Service Provider as a
result of the Holder’s disability, the Holder may exercise his or her Option within such period of time as is specified in the Option Agreement to the extent the Option is vested on the date of termination; provided, however, that
prior to the Public Trading Date, such period of time shall not be less than six (6) months (but in no event later than the expiration of the term of such Option as set forth in the Option Agreement). In the absence of a specified time in the
Option Agreement, the Option shall remain exercisable for twelve (12) months following the Holder’s termination. If such disability is not a “disability” as such term is defined in Section 22(e)(3) of the Code, in the case
of an Incentive Stock Option such Incentive Stock Option shall automatically cease to be treated as an Incentive Stock Option and shall be treated for tax purposes as a Non-Qualified Stock Option from and after the day which is three (3) months
and one (1) day following such termination. If, on the date of termination, the Holder is not vested as to his or her entire Option, the Shares covered by the unvested portion of the Option shall immediately cease to be issuable under the
Option and shall again become available for issuance under the Plan. If, after termination, the Holder does not exercise his or her Option within the time specified herein, the Option shall terminate, and the Shares covered by such Option shall
again become available for issuance under the Plan. 
 (f)        Death of Holder. If a Holder
dies while a Service Provider, the Option may be exercised within such period of time as is specified in the Option Agreement; provided, however, that prior to the Public Trading Date, such period of time shall not be less than six
(6) months (but in no event later than the expiration of the term of such Option as set forth in the Notice of Grant), by the Holder’s estate or by a person who acquires the right to exercise the Option by bequest or inheritance, but only
to the extent that the Option is vested on the date of death. In the absence of a specified time in the Option Agreement, the Option shall remain exercisable for twelve (12) months following the Holder’s termination. If, at the time of
death, the Holder is not vested as to his or her entire Option, the Shares covered by the unvested portion of the Option shall immediately cease to be issuable under the Option and shall again become available for issuance under the Plan. The Option
may be exercised by the executor or administrator of the Holder’s estate or, if none, by the person(s) entitled to exercise the Option under the Holder’s will or the laws of descent or distribution. If the Option is not so exercised within
the time specified herein, the Option shall terminate, and the Shares covered by such Option shall again become available for issuance under the Plan. 
 (g)        Regulatory Extension. A Holder’s Option Agreement may provide that if the exercise of the Option following the termination of the Holder’s status as
a Service Provider (other than upon the Holder’s death or disability) would be prohibited at any time solely because the issuance of shares would violate the registration requirements under the Securities Act, then the Option shall terminate on
the earlier of (i) the expiration of the term of the Option set forth in Section 8 or (ii) the expiration of a period of three (3) months after the termination of the Holder’s status as a Service Provider during which the
exercise of the Option would not be in violation of such registration requirements. 

     (h)         Early Exercisability.
The Administrator may provide in the terms of a Holder’s Option Agreement that the Holder may, at any time before the Holder’s status as a Service Provider terminates, exercise the Option in whole or in part prior to the full vesting of
the Option; provided, however, that subject to Section 20, Shares acquired upon exercise of an Option which has not fully vested may be subject to any forfeiture, transfer or other restrictions as the Administrator may determine in its
sole discretion. 
     (i)         Buyout Provisions. The Administrator
may at any time offer to buyout for a payment in cash or Shares, an Option previously granted, based on such terms and conditions as the Administrator shall establish and communicate to the Holder at the time that such offer is made. 
 11.        Non-Transferability of Options and Stock Purchase Rights. Options and Stock Purchase Rights may
not be sold, pledged, assigned, hypothecated, transferred, or disposed of in any manner other than by will or by the laws of descent or distribution and may be exercised, during the lifetime of the Holder, only by the Holder. 
 12.         Stock Purchase Rights. 
     (a)         Rights to Purchase. Stock Purchase Rights may be issued either alone,
in addition to, or in tandem with Options granted under the Plan and/or cash awards made outside of the Plan. After the Administrator determines that it will offer Stock Purchase Rights under the Plan, it shall advise the offeree in writing of the
terms, conditions and restrictions related to the offer, including the number of Shares that such person shall be entitled to purchase, the price to be paid, and the time within which such person must accept such offer; provided, however,
that to the extent required to comply with applicable securities laws, the purchase price of such Shares shall not be less than the purchase price requirements set forth in Section 260.140.42 of Title 10 of the California Code of Regulations.
The offer shall be accepted by execution of a Restricted Stock purchase agreement in the form determined by the Administrator. 
     (b)         Repurchase Right. Unless the Administrator determines otherwise, the Restricted Stock purchase agreement shall grant the Company the right to repurchase
Shares acquired upon exercise of a Stock Purchase Right upon the termination of the purchaser’s status as a Service Provider for any reason. Subject to Section 20, the purchase price for Shares repurchased by the Company pursuant to such
repurchase right and the rate at which such repurchase right shall lapse shall be determined by the Administrator in its sole discretion, and shall be set forth in the Restricted Stock purchase agreement. 
     (c)         Other Provisions. The Restricted Stock purchase agreement shall
contain such other terms, provisions and conditions not inconsistent with the Plan as may be determined by the Administrator in its sole discretion. 
     (d)         Rights as a Shareholder. Once the Stock Purchase Right is exercised, the purchaser shall have rights equivalent to those of a
shareholder and shall be a shareholder when his or her purchase is entered upon the records of the duly authorized transfer agent of the Company. No adjustment shall be made for a dividend or other right for which the record date is prior to the
date the Stock Purchase Right is exercised, except as provided in Section 13 of the Plan. 

 13.         Adjustments upon Changes in Capitalization, Merger
or Asset Sale. 
     (a)         In the event that the Administrator
determines that any dividend or other distribution (whether in the form of cash, Common Stock, other securities, or other property), recapitalization, reclassification, stock split, reverse stock split, reorganization, merger, consolidation,
split-up, spin-off, combination, repurchase, liquidation, dissolution, or sale, transfer, exchange or other disposition of all or substantially all of the assets of the Company, or exchange of Common Stock or other securities of the Company,
issuance of warrants or other rights to purchase Common Stock or other securities of the Company, or other similar corporate transaction or event, in the Administrator’s sole discretion, affects the Common Stock such that an adjustment is
determined by the Administrator to be appropriate in order to prevent dilution or enlargement of the benefits or potential benefits intended by the Company to be made available under the Plan or with respect to any Option, Stock Purchase Right or
Restricted Stock, then the Administrator shall, in such manner as it may deem equitable, adjust any or all of: 
         (i)         the number and kind of shares of Common Stock (or other securities or property) with respect to which Options or Stock Purchase Rights may
be granted or awarded (including, but not limited to, adjustments of the limitations in Section 3 on the maximum number and kind of shares which may be issued and adjustments of the maximum number of Shares that may be purchased by any Holder
in any calendar year pursuant to Section 6(c)); 
         (ii)
        the number and kind of shares of Common Stock (or other securities or property) subject to outstanding Options, Stock Purchase Rights or Restricted Stock; and 
         (iii)       the grant or exercise price with respect to any Option or
Stock Purchase Right. 
     (b)         In the event of any transaction or event
described in Section 13(a), the Administrator, in its sole discretion, and on such terms and conditions as it deems appropriate, either by the terms of the Option, Stock Purchase Right or Restricted Stock or by action taken prior to the
occurrence of such transaction or event and either automatically or upon the Holder’s request, is hereby authorized to take any one or more of the following actions whenever the Administrator determines that such action is appropriate in order
to prevent dilution or enlargement of the benefits or potential benefits intended by the Company to be made available under the Plan or with respect to any Option, Stock Purchase Right or Restricted Stock granted or issued under the Plan or to
facilitate such transaction or event: 
         (i)
        To provide for either the purchase of any such Option, Stock Purchase Right or Restricted Stock for an amount of cash equal to the amount that could have been obtained upon the exercise of such Option
or Stock Purchase Right or realization of the Holder’s rights had such Option, Stock Purchase Right or Restricted Stock been currently exercisable or payable or fully vested or the replacement of such Option, Stock Purchase Right or Restricted
Stock with other rights or property selected by the Administrator in its sole discretion; 

         (ii)         To
provide that such Option or Stock Purchase Right shall be exercisable as to all shares covered thereby, notwithstanding anything to the contrary in the Plan or the provisions of such Option or Stock Purchase Right; 
         (iii)       To provide that such Option, Stock Purchase Right or
Restricted Stock be assumed by the successor or survivor corporation or entity, or a parent or subsidiary thereof, or shall be substituted for by similar options, rights or awards covering the stock of the successor or survivor corporation or
entity, or a parent or subsidiary thereof, with appropriate adjustments as to the number and kind of shares and prices; 
         (iv)       To make adjustments in the number and type of shares of Common Stock (or other securities or property) subject to outstanding Options and Stock
Purchase Rights, and/or in the terms and conditions of (including the grant or exercise price), and the criteria included in, outstanding Options, Stock Purchase Rights or Restricted Stock or Options, Stock Purchase Rights or Restricted Stock which
may be granted in the future; and 
         (v)       To provide that
immediately upon the consummation of such event, such Option or Stock Purchase Right shall not be exercisable and shall terminate; provided, that for a specified period of time prior to such event, such Option or Stock Purchase Right shall be
exercisable as to all Shares covered thereby, and the restrictions imposed under an Option Agreement or Restricted Stock purchase agreement upon some or all Shares may be terminated and, in the case of Restricted Stock, some or all shares of such
Restricted Stock may cease to be subject to repurchase, notwithstanding anything to the contrary in the Plan or the provisions of such Option, Stock Purchase Right or Restricted Stock purchase agreement. 
     (c)         Subject to Section 3, the Administrator may, in its sole discretion,
include such further provisions and limitations in any Option, Stock Purchase Right, Restricted Stock agreement or certificate, as it may deem equitable and in the best interests of the Company. 
     (d)         If the Company undergoes an Acquisition, then any surviving corporation or
entity or acquiring corporation or entity, or affiliate of such corporation or entity, may assume any Options, Stock Purchase Rights or Restricted Stock outstanding under the Plan or may substitute similar stock awards (including an award to acquire
the same consideration paid to the stockholders in the transaction described in this subsection 13(d)) for those outstanding under the Plan. In the event any surviving corporation or entity or acquiring corporation or entity in an Acquisition, or
affiliate of such corporation or entity, does not assume such Options, Stock Purchase Rights or Restricted Stock or does not substitute similar stock awards for those outstanding under the Plan, then with respect to (i) Options, Stock Purchase
Rights or Restricted Stock held by participants in the Plan whose status as a Service Provider has not terminated prior to such event, the vesting of such Options, Stock Purchase Rights or Restricted Stock (and, if applicable, the time during which
such awards may be exercised) shall be accelerated and made fully exercisable and all restrictions thereon shall lapse at least ten (10) days prior to the closing of the Acquisition (and the Options or Stock Purchase Rights terminated if not
exercised prior to the closing of such Acquisition), and (ii) any other Options or Stock Purchase Rights outstanding under the Plan, such Options or Stock Purchase rights shall be terminated if not exercised prior to the closing of the
Acquisition. 

 (e)         The existence of the Plan, any Option Agreement or
Restricted Stock purchase agreement and the Options or Stock Purchase Rights granted hereunder shall not affect or restrict in any way the right or power of the Company or the stockholders of the Company to make or authorize any adjustment,
recapitalization, reorganization or other change in the Company’s capital structure or its business, any merger or consolidation of the Company, any issue of stock or of options, warrants or rights to purchase stock or of bonds, debentures,
preferred or prior preference stocks whose rights are superior to or affect the Common Stock or the rights thereof or which are convertible into or exchangeable for Common Stock, or the dissolution or liquidation of the Company, or any sale or
transfer of all or any part of its assets or business, or any other corporate act or proceeding, whether of a similar character or otherwise. 
 14.         Time of Granting Options and Stock Purchase Rights. The date of grant of an Option or Stock Purchase Right shall, for all purposes, be the date on which the Administrator makes the
determination granting such Option or Stock Purchase Right, or such other date as is determined by the Administrator. Notice of the determination shall be given to each Employee or Consultant to whom an Option or Stock Purchase Right is so granted
within a reasonable time after the date of such grant. 
 15.         Amendment and Termination of
the Plan. 
     (a)         Amendment and Termination. The Board may
at any time wholly or partially amend, alter, suspend or terminate the Plan. However, without approval of the Company’s stockholders given within twelve (12) months before or after the action by the Board, no action of the Board may,
except as provided in Section 13, increase the limits imposed in Section 3 on the maximum number of Shares which may be issued under the Plan or extend the term of the Plan under Section 7. 
     (b)         Stockholder Approval. The Board shall obtain stockholder approval of
any Plan amendment to the extent necessary and desirable to comply with Applicable Laws. 
     (c)
        Effect of Amendment or Termination. No amendment, alteration, suspension or termination of the Plan shall impair the rights of any Holder, unless mutually agreed otherwise between the Holder and
the Administrator, which agreement must be in writing and signed by the Holder and the Company. Termination of the Plan shall not affect the Administrator’s ability to exercise the powers granted to it hereunder with respect to Options, Stock
Purchase Rights or Restricted Stock granted or awarded under the Plan prior to the date of such termination. 
 16.        Stockholder Approval. The Plan will be submitted for the approval of the Company’s stockholders within twelve (12) months after the date of the Board’s initial
adoption of the Plan. Options, Stock Purchase Rights or Restricted Stock may be granted or awarded prior to such stockholder approval, provided that such Options, Stock Purchase Rights and Restricted Stock shall not be exercisable, shall not vest
and the restrictions thereon shall not lapse prior to the time when the Plan is approved by the stockholders, and provided further that if such 

 
approval has not been obtained at the end of said twelve-month period, all Options, Stock Purchase Rights and Restricted Stock previously granted or awarded
under the Plan shall thereupon be canceled and become null and void. 
 17.         Inability to
Obtain Authority. The inability of the Company to obtain authority from any regulatory body having jurisdiction, which authority is deemed by the Company’s counsel to be necessary to the lawful issuance and sale of any Shares hereunder,
shall relieve the Company of any liability in respect of the failure to issue or sell such Shares as to which such requisite authority shall not have been obtained. 
 18.         Reservation of Shares. The Company, during the term of this Plan, shall at all times reserve and keep available such number of Shares as shall be sufficient
to satisfy the requirements of the Plan. 
 19.         Information to Holders and Purchasers.
Prior to the Public Trading Date and to the extent required by Section 260.140.46 of Title 10 of the California Code of Regulations, the Company shall provide to each Holder and to each individual who acquires Shares pursuant to the Plan, not
less frequently than annually during the period such Holder or purchaser has one or more Options or Stock Purchase Rights outstanding, and, in the case of an individual who acquires Shares pursuant to the Plan, during the period such individual owns
such Shares, copies of annual financial statements. Notwithstanding the preceding sentence, the Company shall not be required to provide such statements to key employees whose duties in connection with the Company assure their access to equivalent
information. 
 20.         Repurchase Provisions. The Administrator in its sole discretion
may provide that the Company may repurchase Shares acquired upon exercise of an Option or Stock Purchase Right upon the occurrence of certain specified events, including, without limitation, a Holder’s termination as a Service Provider,
divorce, bankruptcy or insolvency; provided, however, that any such repurchase right shall be set forth in the applicable Option Agreement or Restricted Stock purchase agreement or in another agreement referred to in such agreement and,
provided further, that to the extent required by Section 260.140.41 and Section 260.140.42 of Title 10 of the California Code of Regulations, any such repurchase right set forth in an Option or Stock Purchase Right granted prior to the
Public Trading Date to a person who is not an Officer, Director or Consultant shall be upon the following terms: (i) if the repurchase option gives the Company the right to repurchase the shares upon termination as a Service Provider at not
less than the Fair Market Value of the shares to be purchased on the date of termination of status as a Service Provider, then (A) the right to repurchase shall be exercised for cash or cancellation of purchase money indebtedness for the shares
within ninety (90) days of termination of status as a Service Provider (or in the case of shares issued upon exercise of Options or Stock Purchase Rights after such date of termination, within ninety (90) days after the date of the
exercise) or such longer period as may be agreed to by the Administrator and the Plan participant and (B) the right terminates when the shares become publicly traded; and (ii) if the repurchase option gives the Company the right to
repurchase the Shares upon termination as a Service Provider at the original purchase price for such Shares, then (A) the right to repurchase at the original purchase price shall lapse at the rate of at least twenty percent (20%) of the
shares per year over five (5) years from the date the Option or Stock Purchase Right is granted (without respect to the date the Option or Stock Purchase Right was exercised or became exercisable) and (B) the right to 

 
repurchase shall be exercised for cash or cancellation of purchase money indebtedness for the shares within ninety (90) days of termination of status as
a Service Provider (or, in the case of shares issued upon exercise of Options or Stock Purchase Rights, after such date of termination, within ninety (90) days after the date of the exercise) or such longer period as may be agreed to by the
Company and the Plan participant. 
 21.         Investment Intent. The Company may require a
Plan participant, as a condition of exercising or acquiring stock under any Option or Stock Purchase Right, (i) to give written assurances satisfactory to the Company as to the participant’s knowledge and experience in financial and
business matters and/or to employ a purchaser representative reasonably satisfactory to the Company who is knowledgeable and experienced in financial and business matters and that he or she is capable of evaluating, alone or together with the
purchaser representative, the merits and risks of exercising the Option or Stock Purchase Right; and (ii) to give written assurances satisfactory to the Company stating that the participant is acquiring the stock subject to the Option or Stock
Purchase Right for the participant’s own account and not with any present intention of selling or otherwise distributing the stock. The foregoing requirements, and any assurances given pursuant to such requirements, shall be inoperative if
(A) the issuance of the shares upon the exercise or acquisition of stock under the applicable Option or Stock Purchase Right has been registered under a then currently effective registration statement under the Securities Act or (B) as to
any particular requirement, a determination is made by counsel for the Company that such requirement need not be met in the circumstances under the then applicable securities laws. The Company may, upon advice of counsel to the Company, place
legends on stock certificates issued under the Plan as such counsel deems necessary or appropriate in order to comply with applicable securities laws, including, but not limited to, legends restricting the transfer of the stock. 
 22.         Lock-Up Period. Each Holder shall, as a condition of any grant of an Option or Stock Purchase
Right hereunder, agree that if so requested by the Company or any representative of the underwriters (the “Managing Underwriter”) in connection with any registration of the offering of any securities of the Company under the
Securities Act, he or she shall not sell or otherwise transfer any Shares or other securities of the Company during the 180-day period (or such longer period as may be requested in writing by the Managing Underwriter and agreed to in writing by
the Company) (the “Market Standoff Period”) following the effective date of a registration statement of the Company filed under the Securities Act; provided, however, that such restriction shall apply only to the first registration
statement of the Company to become effective under the Securities Act that includes securities to be sold on behalf of the Company to the public in an underwritten public offering under the Securities Act. The Company may impose stop-transfer
instructions with respect to securities subject to the foregoing restrictions until the end of such Market Standoff Period. 
 23.
        Agreement to be Bound by Stockholders Agreement. Each Holder shall, as a condition of any grant of an Option or Stock Purchase Right hereunder, agree that if so requested by the Company or if
Holder’s total ownership of capital stock or Common Stock Equivalents (as defined in that certain Second Amended and Restated Stockholders Agreement by and among the Company and certain stockholders, as may be amended from time to time (the
“Stockholders Agreement”)) subsequent to the issuance of an Option or Stock Purchase Right is equal to or greater than 0.5% of the total number of issued and outstanding shares of Common Stock of the 

 
Company at the time of such issuance, on a fully-diluted, as-if-converted to Common Stock basis, including all shares of Common Stock reserved for issuance
under any Company Stock Option Plans (as defined in the Stockholders Agreement), Holder shall execute and deliver either (a) an instrument substantially in the form attached as Exhibit A-2 to the Stockholders Agreement, or (b) an
agreement with the Company restricting the transfer of its, his or her shares of Common Stock in form and substance reasonably satisfactory to the Stockholders (as defined in the Stockholders Agreement). 
 24.         Governing Law. The validity and enforceability of this Plan shall be governed by and construed
in accordance with the laws of the State of Delaware without regard to otherwise governing principles of conflicts of law. 
 * * * * * * *

 MAP PHARMACEUTICALS, INC. 
 2005 EQUITY INCENTIVE PLAN 
 STOCK OPTION AGREEMENT 
 Unless otherwise defined herein, the terms defined in the Plan shall have the same defined meanings in this Stock Option Agreement. 
  

	I.	NOTICE OF STOCK OPTION GRANT 

 [Optionee]

 [Address] 
 You
(“Optionee”) have been granted an option to purchase Common Stock of the Company, subject to the terms and conditions of the Plan and this Stock Option Agreement. The terms of your grant are set forth below: 
  

					
	Date of Grant:	  		    	
			
	Vesting Commencement Date:	  		    	
			
	Exercise Price per Share:	  		    	$______ per share
			
	Total Number of Shares Granted:	  		    	
			
	Total Exercise Price:	  		    	$______
			
	Type of Option:	  	______	    	Incentive Stock Option
			
		  	______	    	Non-Qualified Stock Option
			
	Term/Expiration Date:	  		    	

 Exercise and Vesting Schedule: 
 The Shares subject to this Option shall vest according to the following schedule: 
 Twenty-five percent (25%) of the Shares subject to the Option (rounded down to the next whole
number of shares) shall vest one year after the Vesting Commencement Date, and 1/48th of the Shares subject to the
Option (rounded down to the next whole number of shares) shall vest on the first day of each full month thereafter, so that all of the Shares shall be vested on the first day of the forty-eighth (48th) month after the Vesting Commencement Date.

 Termination Period: 
 This Option may be exercised, to the extent vested, for ninety (90) days after Optionee ceases to be a Service Provider, or such longer period as may be applicable upon the death or disability of Optionee as
provided herein (or, if not provided herein, then as provided in the Plan), but in no event later than the Term/Expiration Date as provided above. 
  

	II.	AGREEMENT 

 1.      Grant of Option. The Company hereby grants to the Optionee an Option to purchase the Common Stock (the “Shares”) set forth in the Notice of Grant, at the exercise price per share set
forth in the Notice of Grant (the “Exercise Price”). Notwithstanding anything to the contrary anywhere else in this Option Agreement, this grant of an Option is subject to the terms, definitions and provisions of the MAP Pharmaceuticals,
Inc. 2005 Equity Incentive Plan (the “Plan”) adopted by the Company, which is incorporated herein by reference. 
 If designated in
the Notice of Grant as an Incentive Stock Option, this Option is intended to qualify as an Incentive Stock Option as defined in Section 422 of the Code; provided, however, that to the extent that the aggregate Fair Market Value of stock with
respect to which Incentive Stock Options (within the meaning of Code Section 422, but without regard to Code Section 422(d)), including the Option, are exercisable for the first time by the Optionee during any calendar year (under the Plan
and all other incentive stock option plans of the Company or any Subsidiary) exceeds $100,000, such options shall be treated as not qualifying under Code Section 422, but rather shall be treated as Non-Qualified Stock Options to the extent
required by Code Section 422. The rule set forth in the preceding sentence shall be applied by taking options into account in the order in which they were granted. For purposes of these rules, the Fair Market Value of stock shall be determined
as of the time the option with respect to such stock is granted. 
 2.      Exercise of Option. This
Option is exercisable as follows: 
 (a)    Right to Exercise. 
 (i) This Option shall be exercisable cumulatively according to the vesting schedule set out in the Notice of Grant. For purposes of this Stock Option
Agreement, Shares subject to this Option shall vest based on Optionee’s continued status as a Service Provider. 
 (ii) This Option may
not be exercised for a fraction of a Share. 
  

 2 

 (iii) In the event of Optionee’s death, disability or other termination of the Optionee’s
status as a Service Provider, the exercisability of the Option is governed by Sections 7, 8 and 9 below. 
 (iv) In no event may this
Option be exercised after the date of expiration of the term of this Option as set forth in the Notice of Grant. 
 (b)    Method of Exercise. This Option shall be exercisable by written Notice (in the form attached as Exhibit A). The Notice must state the number of Shares for which the Option is being exercised, and
such other representations and agreements with respect to such shares of Common Stock as may be required by the Company pursuant to the provisions of the Plan. The Notice must be signed by the Optionee and shall be delivered in person or by
certified mail to the Secretary of the Company. The Notice must be accompanied by payment of the Exercise Price, including payment of any applicable withholding tax. This Option shall be deemed to be exercised upon receipt by the Company of such
written Notice accompanied by the Exercise Price and payment of any applicable withholding tax. 
 No Shares shall be issued pursuant to the
exercise of an Option unless such issuance and such exercise comply with all relevant provisions of law and the requirements of any stock exchange upon which the Shares may then be listed. Assuming such compliance, for income tax purposes the Shares
shall be considered transferred to the Optionee on the date on which the Option is exercised with respect to such Shares. 
 3.      Optionee’s Representations. If the Shares purchasable pursuant to the exercise of this Option have not been registered under the Securities Act of 1933, as amended (the “Securities
Act”), at the time this Option is exercised, Optionee shall, if required by the Company, concurrently with the exercise of all or any portion of this Option, deliver to the Company his or her Investment Representation Statement in the form
attached hereto as Exhibit B. 
 4.      Lock-Up Period. Optionee hereby agrees that if so
requested by the Company or any representative of the underwriters (the “Managing Underwriter”) in connection with any registration of the offering of any securities of the Company under the Securities Act, Optionee shall not sell or
otherwise transfer any Shares or other securities of the Company during the 180-day period (or such longer period as may be requested in writing by the Managing Underwriter and agreed to in writing by the Company) (the “Market Standoff
Period”) following the effective date of a registration statement of the Company filed under the Securities Act; provided, however, that such restriction shall apply only to the first registration statement of the Company to become
effective under the Securities Act that includes securities to be sold on behalf of the Company to the public in an underwritten public offering under the Securities Act. The Company may impose stop-transfer instructions with respect to securities
subject to the foregoing restrictions until the end of such Market Standoff Period. 
 5.      Method of
Payment. Payment of the Exercise Price shall be by any of the following, or a combination thereof, at the election of the Optionee: 
 (a)    cash; 
  

 3 

 (b)    check; 
 (c)    with the consent of the Administrator, surrender of other shares of Common Stock of the Company which (A) in the case of
Shares acquired from the Company, have been owned by the Optionee for more than six (6) months on the date of surrender, and (B) have a Fair Market Value on the date of surrender equal to the Exercise Price of the Shares as to which the
Option is being exercised; 
 (d)    with the consent of the Administrator, surrendered Shares issuable upon the exercise
of the Option having a Fair Market Value on the date of exercise equal to the aggregate Exercise Price of the Option or exercised portion thereof; 
 (e)    with the consent of the Administrator, property of any kind which constitutes good and valuable consideration; or 
 (f)    with the consent of the Administrator, delivery of a notice that the Optionee has placed a market sell order with a broker with respect to Shares then issuable upon exercise of the Option
and that the broker has been directed to pay a sufficient portion of the net proceeds of the sale to the Company in satisfaction of the aggregate Exercise Price; provided, that payment of such proceeds is then made to the Company upon settlement of
such sale. 
 6.      Restrictions on Exercise. This Option may not be exercised until the Plan has been
approved by the stockholders of the Company. If the issuance of Shares upon such exercise or if the method of payment for such shares would constitute a violation of any applicable federal or state securities or other law or regulation, then the
Option may also not be exercised. The Company may require Optionee to make any representation and warranty to the Company as may be required by any applicable law or regulation before allowing the Option to be exercised. 
 7.      Termination of Relationship. If Optionee ceases to be a Service Provider (other than by reason of the
Optionee’s death or the total and permanent disability of the Optionee as defined in Code Section 22(e)(3)), Optionee may exercise this Option during the Termination Period set out in the Notice of Grant, to the extent the Option was
vested at the date of such termination. To the extent that Optionee was not vested in this Option at the date on which Optionee ceases to be a Service Provider, or if Optionee does not exercise this Option within the time specified herein, the
Option shall terminate. 
 8.      Disability of Optionee. If Optionee ceases to be a Service Provider as
a result of his or her total and permanent disability as defined in Code Section 22(e)(3), Optionee may exercise the Option to the extent the Option was vested at the date on which Optionee ceases to be a Service Provider, but only within
twelve (12) months from such date (and in no event later than the expiration date of the term of this Option as set forth in the Notice of Grant). To the extent that the Option is not vested at the date on which Optionee ceases to be a Service
Provider, or if Optionee does not exercise such Option within the time specified herein, the Option shall terminate. 
 9.      Death of Optionee. If Optionee ceases to be a Service Provider as a result of the death of Optionee, the vested portion of the Option may be exercised at any time within twelve (12) months
following the date of death (and in no event later than the expiration date of 

  

 4 

 
the term of this Option as set forth in the Notice of Grant) by Optionee’s estate or by a person who acquires the right to exercise the Option by
bequest or inheritance. To the extent that the Option is not vested at the date of death, or if the Option is not exercised within the time specified herein, the Option shall terminate. 
 10.      Non-Transferability of Option. This Option may not be transferred in any manner except by will or by the
laws of descent or distribution . It may be exercised during the lifetime of Optionee only by Optionee. The terms of this Option shall be binding upon the executors, administrators, heirs, successors and assigns of the Optionee. 
 (a)    Term of Option. This Option may be exercised only within the term set out in the Notice of Grant. 
  
  
 [Signature
page follows] 
  

 5 

 This Agreement may be executed in two or more counterparts, each of which shall be deemed an original and
all of which shall constitute one document. 
  

			
	MAP PHARMACEUTICALS, INC.
		
	By:	 	  
		
	Name:	 	  
		
	Title:	 	  

 OPTIONEE ACKNOWLEDGES AND AGREES THAT THE VESTING OF SHARES PURSUANT TO THE OPTION HEREOF IS
EARNED ONLY BY CONTINUING CONSULTANCY OR EMPLOYMENT AT THE WILL OF THE COMPANY (NOT THROUGH THE ACT OF BEING HIRED, BEING GRANTED THIS OPTION OR ACQUIRING SHARES HEREUNDER). OPTIONEE FURTHER ACKNOWLEDGES AND AGREES THAT NOTHING IN THIS AGREEMENT,
NOR IN THE COMPANY’S 2005 EQUITY INCENTIVE PLAN WHICH IS INCORPORATED HEREIN BY REFERENCE, SHALL CONFER UPON OPTIONEE ANY RIGHT WITH RESPECT TO CONTINUATION OF EMPLOYMENT OR CONSULTANCY BY THE COMPANY, NOR SHALL IT INTERFERE IN ANY WAY WITH
OPTIONEE’S RIGHT OR THE COMPANY’S RIGHT TO TERMINATE OPTIONEE’S EMPLOYMENT OR CONSULTANCY AT ANY TIME, WITH OR WITHOUT CAUSE. 
 Optionee acknowledges receipt of a copy of the Plan and represents that he is familiar with the terms and provisions thereof. Optionee hereby accepts this Option subject to all of the terms and provisions hereof. Optionee has reviewed the
Plan and this Option in their entirety, has had an opportunity to obtain the advice of counsel prior to executing this Option and fully understands all provisions of the Option. Optionee hereby agrees to accept as binding, conclusive and final all
decisions or interpretations of the Administrator upon any questions arising under the Plan or this Option. Optionee further agrees to notify the Company upon any change in the residence address indicated below. 
  

									
					
	Dated:	 	  	 		 		 	  
		 		 		 		 	[OPTIONEE]
				
		 		 		 	Residence Address:
					
		 		 		 		 	  
					
		 		 		 		 	  

  

 6

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