Document:

LOAN AGREEMENT DATED APRIL 19, 2002

 Exhibit 10.3 
  
 LOAN AGREEMENT 
  
 This Loan Agreement (“Agreement”), dated as of the 19th day of April, 2002, is made and entered into between TARGACEPT, INC., a Delaware corporation (“Borrower”), and the CITY OF WINSTON-SALEM, a
municipal corporation of North Carolina (“Lender”). 
  
 RECITALS: 
  
 WHEREAS, Borrower has requested that
Lender make available to Borrower a loan in the principal amount of $500,000 (the “Loan”) on the terms and conditions hereinafter set forth; and 
  
 WHEREAS, in order to induce Lender to make the Loan to Borrower, Borrower has made certain representations to Lender; and

  
 WHEREAS, Lender, in reliance upon the representations of
Borrower, has agreed to make the Loan upon the terms and conditions hereinafter set forth; 
  
 NOW, THEREFORE, in consideration of the agreement of Lender to make the Loan, the mutual covenants and agreements hereinafter set forth, and other good and valuable consideration, the receipt and sufficiency of which
are hereby acknowledged, Borrower and Lender hereby agree as follows: 
  
 ARTICLE I  
 LOAN 
  
 1.1 Description of Loan. The Loan shall be evidenced by a Note (the “Note”) dated as of the date hereof (the “Issue
Date”) in the amount of Five Hundred Thousand and No/100 Dollars ($500,000). The Loan shall be payable over a term of one hundred and twenty (120) months. The date that one hundred and twenty (120) months from the date hereof is referred to
herein as the “Maturity Date.” Except as provided in Section 4.2, the Loan shall bear no interest from the Issue Date until the date that is sixty (60) months from the Issue Date (the “Anniversary Date”). Except as
provided in Section 4.2, from the Anniversary Date until the Maturity Date, the Loan shall bear interest during each fiscal year based on Borrower’s Gross Revenues during Borrower’s preceding fiscal year as follows: 
  

					
	 Period

	  	 Gross Revenues for Preceding Fiscal Year

	  	Applicable Interest Rate
Per Annum

	Anniversary Date - December 31, 2007	  	Greater than or equal to $100,000,000	  	7%
	  	Less than $100,000,000	  	5%

  

					
	January 1, 2008-December 31,2008	  	Greater than or equal to $100,000,000	  	7%
	  	Less than $100,000,000	  	5%
			
	January 1, 2009-December 31,2009	  	Greater than or equal to $100,000,000	  	7%
	  	Less than $100,000,000	  	5%
			
	January 1, 2010-December 31,2010	  	Greater than or equal to $100,000,000	  	7%
	  	Less than $100,000,000	  	5%
			
	January 1, 2011-December 31, 2011	  	Greater than or equal to $100,000,000	  	7%
	  	Less than $100,000,000	  	5%
			
	January 1, 2012-Maturity Date	  	Greater than or equal to $100,000,000	  	7%
	  	Less than $100,000,000	  	5%

  
 For example, the applicable interest
rate per annum for the period beginning on the Anniversary Date and ending on December 31, 2007 shall be either 7% if Borrower’s Gross Revenues during the fiscal year ending December 31, 2006 are greater than or equal to $100,000,000, or 5% if
Borrower’s Gross Revenues during the fiscal year ending December 31, 2006 are less than $100,000,000. The applicable interest rate per annum for the period beginning on January 1, 2008 and ending on December 31,2008 shall be either 7% if
Borrower’s Gross Revenues for the fiscal year ending December 31, 2007 are greater than or equal to $100,000,000, or 5% if Borrower’s Gross Revenues during the fiscal year ending December 31, 2007 are less than $100,000,000. Gross Revenues
shall mean total sales of Borrower before any deductions for expenses or costs. The applicable interest rate shall be determined based on an officer’s certificate delivered annually by Borrower in accordance with Section 3.2 and shall be
adjusted as of the first day of the year following the fiscal year as to which the officer’s certificate relates; provided, however, that if Borrower fails to provide any officer’s certificate to Lender as required 

  

 2 

 
by and within the time limits set forth in Section 3.2, the applicable interest rate from January 1 of such year until an appropriate officer’s
certificate is provided shall be seven percent (7%). 
  
 No payment of principal
or interest shall be due until the Anniversary Date. Beginning on the Anniversary Date and continuing on a monthly basis, Borrower shall pay to Lender monthly installments of principal and interest in the amount of Nine Thousand Four Hundred
Thirty-Five and 63/100 Dollars ($9,435.63), with all remaining principal and unpaid interest payable on the Maturity Date. Upon an Event of Default, the amount of unpaid principal and interest and all other sums due under this Loan Agreement shall
bear interest at the rate of sixteen percent (16%) per annum after default until paid. Interest on the Loan shall be computed on the basis of a 360-day year of twelve 30-day months. The Loan may be prepaid in full or in part at any time without
penalty or premium. 
  
 ARTICLE II 
 WARRANTIES 
  
 Borrower hereby warrants to Lender as follows: 
  
 2.1 Corporate Status. Borrower is a corporation duly organized, validly existing, and in good standing under the laws of the state of Delaware and
has the corporate power to own and operate its properties, to carry on its business as now conducted, and to enter into and to perform its obligations under this Agreement and the Note. 
  
 2.2 Authorization. Except as disclosed on Schedule 2.2, Borrower has full legal right, power, and authority to
enter into and perform its obligations under this Agreement and the Note, without the consent or approval of any other person, firm, governmental agency, or other legal entity. The execution and delivery of this Agreement, the borrowing hereunder,
the execution and delivery of the Note, and the performance by Borrower of its obligations hereunder and thereunder are within its corporate powers and have been duly authorized by all necessary corporate action properly taken, have received all
necessary governmental approvals, and do not and will not contravene or conflict with any material provision of law, any material applicable judgment, ordinance, regulation, or order of any court or governmental agency, the charter or bylaws of
Borrower, or any material agreement binding upon it or its properties. 
  
 2.3 Validity and Binding Effect. This Agreement and the Note are the legal, valid, and binding obligations of Borrower, enforceable in accordance with their terms. 
  
 2.4 No Consent Required. Except as disclosed on Schedule 2.4, the execution, delivery, and performance of this
Agreement and the Note by Borrower do not require the consent or approval of or the giving of notice to any person or entity other than the approval of the Board of Directors of Borrower. 
  
 2.5 Solvency. Borrower is solvent as of the date of this Agreement. For purposes of this Section 2.5,
“solvent” shall mean Borrower (i) is able to pay its debts as they mature, and (ii) owns assets having present fair saleable value greater than the amount required to pay its debts. 
  

 3 

 2.6 Survival. The representations and warranties of Borrower contained in this Agreement shall
survive until this Agreement terminates in accordance with Article V hereof. 
  
 ARTICLE III 
 COVENANTS AND AGREEMENTS 
  
 3.1 Payment of Indebtedness. Borrower shall pay the indebtedness evidenced by the Note according to the terms
thereof. 
  
 3.2 Financial Reports. Until this Agreement
terminates in accordance with Article V hereof, Borrower will furnish to Lender within one hundred twenty (120) days after the close of each fiscal year of Borrower a certificate, executed by the chief financial officer, controller, or treasurer of
Borrower, setting forth the true and correct amount of Gross Revenues of Borrower for such fiscal year. 
  
 3.3 No Relocation. Until this Agreement terminates in accordance with Articles V hereof, Borrower agrees not to relocate outside of the City of
Winston-Salem (i) its principal place of business; (ii) any material portion of its primary operations, including, but not limited to, its research and technology, manufacturing, or administrative divisions, or (iii) any material number of its
employees with respect to any division of Borrower. 
  
 3.4
Notice of Default. Until this Agreement terminates in accordance with Article V hereof, Borrower shall give written notice to Lender of the occurrence of any Event of Default (as defined below) under this Agreement or the Note of which
Borrower becomes aware promptly upon the occurrence thereof. 
  
 ARTICLE IV 
 DEFAULT AND REMEDIES 
  
 4.1 Events of Default. The occurrence of any of the following shall constitute an Event of Default hereunder: 
  
 (a) Default in the payment of the principal of or interest
on the indebtedness evidenced by the Note in accordance with the terms of the Note; 
  
 (b) Any material misrepresentation by Borrower as to any matter hereunder; 
  
 (c) Failure of Borrower to perform any of its obligations under this Agreement; 
  
 (d) Borrower’s (i) admission in writing of its
inability to pay its debts generally as they become due; (ii) assignment for the benefit of creditors or petition or application to any tribunal for the appointment of a custodian, receiver, or trustee for it or a substantial part of its assets; or
(iii) voluntary commencement of any proceeding under any 

  

 4 

 
bankruptcy, reorganization, arrangement, readjustment of debt, dissolution, or liquidation law or statute of any jurisdiction, whether now or hereafter in
effect, or the involuntary commencement of any such proceeding that is not dismissed within sixty (60) days; 
  
 (e) Borrower ceases to do business or sells all or substantially all of its assets or properties; or 
  
 (f) Borrower’s liquidation or dissolution; 

 
 provided, however, that with respect to any default described above that is capable of
being cured, the occurrence of such default shall not constitute an Event of Default hereunder if such default is fully cured and corrected within thirty (30) days (ten (10) days, if such default may be cured by payment of a sum of money) of notice
thereof to Borrower. 
  
 4.2 Acceleration of Maturity. Upon
the occurrence of any Event of Default described in Section 4.1, the indebtedness evidenced by the Note shall be immediately due and payable in full. In addition, if the Event of Default is caused by a breach by Borrower of its covenants contained
in Section 3.3, Borrower agrees that the indebtedness immediately due and payable shall include all unpaid principal and interest computed as if the interest payable pursuant to the Note beginning on the Issue Date and continuing over the term of
the Note were seven percent (7%). 
  
 4.3 Remedies Cumulative;
No Waiver. No right, power, or remedy conferred upon or reserved to Lender by this Agreement or the Note is intended to be exclusive of any other right, power, or remedy, but each and every such right, power, and remedy shall be cumulative and
concurrent and shall be in addition to any other right, power, and remedy given hereunder or under the Note or now or hereafter existing at law, in equity, or by statute. No delay or omission by Lender to exercise any right, power, or remedy
accruing upon the occurrence of any Event of Default shall exhaust or impair any such right, power, or remedy or shall be construed to be a waiver of any such Event of Default or an acquiescence therein, and every right, power, and remedy given by
this Agreement and the Note to Lender may be exercised from time to time and as often as may be deemed expedient by Lender. 
  
 ARTICLE V  
 TERMINATION

  
 This Agreement shall remain in full force and effect until the
repayment in full of the Note. 
  
 ARTICLE VI 
 MISCELLANEOUS 
  
 6.1 Successors and Assigns. The Agreement shall inure to the benefit of the successors and permitted assigns of the parties hereto. 
  

 5 

 6.2 Assignment. Neither this Agreement nor the Note may be assigned by Borrower without the prior
written consent of Lender. 
  
 6.3 Time of the Essence.
Time is of the essence with respect to each and every covenant, agreement, and obligation of Borrower and Lender hereunder and under the Note. 
  
 6.4 Severability. If any provision of this Agreement or the application thereof to any person or circumstance shall be invalid or unenforceable to
any extent, the remainder of this Agreement and the application of such provisions to other persons or circumstances shall not be affected thereby and shall be enforced to the greatest extent permitted by law. 
  
 6.5 Notices. All notices and other communications hereunder shall be
deemed given if given in writing and delivered personally, by courier or by facsimile transmission, or mailed by registered or certified mail (return receipt requested), courier, facsimile, or postage fees prepaid, to the party to receive the same
at its address set forth below (or at such other address as may from time to time be designated by such party to the other in accordance with this Section 6.5): 
  
 If to Lender: 
  
 The City of Winston-Salem 
 P.O. Box 2511

 Winston-Salem, NC 27102 
 Telephone: 336-727-8040 
 Attention: Derwick L. Paige 
  
 If to Borrower: 
  
 Targacept, Inc. 
 200 East First Street, Suite
300 
 Winston-Salem, NC 27101 
 Telephone: 336-480-2186 
 Facsimile: 336-480-2112 
 Attention: Alan A. Musso, Vice President and Chief Financial Officer 
  
 6.6 Entire Agreement. This Agreement and the Note represent the entire agreement between the parties concerning the subject matter hereof.

  
 6.7 Governing Law. This Agreement shall be construed
and enforced under the laws of the State of North Carolina without regard to the conflicts of laws thereunder. 
  
 6.8 Counterparts. This Agreement may be executed in multiple originals or counterparts, each of which shall be deemed an original and all or which
when taken together shall constitute but one and the same instrument. 
  
 6.9 Amendments. No amendment or modification hereof shall be effective except in a writing executed by each of the parties hereto. 
  

 6 

 IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the day and year first above
written. 
  

			
	 BORROWER:

	
	 TARGACEPT, INC.

		
	By:	 	 /s/ Alan A. Musso

	 	 	

	 Name:
	 	 Alan A. Musso

	 Title:
	 	 Chief Financial Officer

  

			
	 LENDER:

	
	 CITY OF WINSTON-SALEM

		
	By:	 	 /s/ Derwick L. Paige

	 	 	

	 Name:
	 	 Derwick L. Paige

	 Title:
	 	 Development Director

  

 7AMENDED AND RESTATED NOTE AND SECURITY AGREEMENT

 Exhibit 10.4 
  
 Amended and Restated Note and Security Agreement 
  
 Winston-Salem. North Carolina 
  

			
	Date January 30, 2004	  	Up to $4,500,000

  
 FOR VALUE RECEIVED, Targacept, Inc., a
corporation organized and existing under the laws of the State of Delaware with its principal executive office located at 200 East First Street, Suite 300, Winston-Salem, North Carolina 27102-1465 (hereinafter the “Borrower”), hereby
promises to pay to the order of R.J. Reynolds Tobacco Holdings, Inc. (hereinafter the “Lender”) at its office where borrowed, or at such other place as Lender hereafter may direct from time to time in writing, in immediately available
funds of lawful money of the United States, the sum of Four Million Five Hundred Thousand Dollars (or the unpaid principal amount of all advances which the Lender actually makes hereunder to the Borrower, whichever is less) together with any unpaid
interest hereon from date of advance, in accordance with the terms contained in this Amended and Restated Note and Security Agreement (hereinafter referred to as this “Note”). The principal evidenced by this Note shall be advanced
periodically from time to time in accordance with the terms of this paragraph in up to four disbursements (each such disbursement is referred to herein as a “Tranche”). The first Tranche is in the amount of $2,500,000, was advanced to the
Borrower on May 1, 2002 and is payable in accordance with the terms set forth herein (the “First Tranche”). The Lender acknowledges that the Borrower is current as of the date of this Note with all payments due with respect to the First
Tranche. The remaining principal amount evidenced by this Note may be advanced in up to three Tranches, the aggregate principal amount of which shall not exceed $2,000,000 (referred to herein individually as an “Additional Tranche” and
collectively referred to herein as the “Additional Tranches”). 
  
 Upon
written request of the Borrower, which shall be made in writing and delivered to the Lender on a business day not more than 45 nor fewer than 5 business days prior to the desired date of disbursement the Lender shall, subject to the terms and
conditions set forth herein, advance an Additional Tranche to the Borrower provided that: (1) such written request shall set forth the principal amount of the proposed Additional Tranche, the proposed date of disbursement of the Additional Tranche
and a description of the equipment, goods and other property purchased or to be purchased with the proceeds of such Additional Tranche; (2) in no event shall the Lender be obligated to advance more than three Additional Tranches or shall the
aggregate initial principal amount of the First Tranche and all Additional Tranches exceed $4,500,000; (3) the Borrower’s written request may be made only so long as an Event of Default has not occurred hereunder and must be delivered to the
Lender such that the date that such Additional Tranche is disbursed occurs on or before December 31, 2004. The Collateral securing the Tranches shall be evaluated by Lender at the time of each requested disbursement of an Additional Tranche to
determine whether the Collateral has sufficient value to secure such Additional Tranche. In the event Lender makes a good faith determination that the Collateral is not of sufficient value to secure such Additional Tranche, Lender shall postpone
disbursement of the Additional Tranche until such time that Lender determines in good faith that the Collateral has sufficient value to secure it. Lender shall use its best efforts to make such determinations in a timely manner. On the date that
each Additional Tranche is advanced, the Borrower and the Lender shall execute a schedule supplementing Exhibit A to this Note, as the Lender shall reasonably request, to add additional Collateral that is to secure the Tranches, if any,
confirm the outstanding principal amount of the outstanding Tranches and to evidence the rate of interest applicable to the Additional Tranche and the repayment dates for the Additional Tranche, and each such supplemental schedule shall thereupon
become part of this Note. 
  
 Repayment: 
  
 xThe First Tranche shall be paid in 48 equal monthly
payments of $59,402.75 beginning June 1, 2002 and continuing on the first day of each month thereafter until May 1, 2006 when the entire outstanding principal amount of such First Tranche then outstanding and all accrued but unpaid interest shall be
paid in full. Each Additional Tranche shall be repaid in 48 equal monthly payments based on a 48-month amortization schedule beginning on the first day of the first calendar month that begins after the date such Additional Tranche is advanced and
continuing on the first day of each month thereafter until the 48th month thereafter when the entire outstanding
principal amount of such Additional Tranche then outstanding and all accrued but unpaid interest shall be paid in full. 
  
 If advances of the principal amount hereof are to be made by Lender to the Borrower after the date of this Note, Lender, at its sole discretion, is hereby authorized to
make such advances under this Note upon telephonic or written communication of a borrowing request from any person representing himself or herself to be the Borrower or, in the event the Borrower is an organization, a duly authorized officer or
representative of Borrower. 
  
 Interest: 
 Payable: 
  
 x in arrears. 
  
 x At the fixed rate per annum of 6.6% for the First Tranche. 
  
 x At an interest rate(s) per annum for each Additional Tranche established on the date such Applicable Tranche is advanced that approximates the hypothetical 4-year U.S. Treasury
rate (determined as of the day the Applicable Tranche is advanced) plus 3.5%. 
  
 In no case shall interest exceed the maximum rate permitted by applicable law. 
  
 In addition to any other collateral specified herein, to secure the indebtedness evidenced by this Note, together with any extensions, modifications, or renewals thereof, in whole or in part, as well as all other indebtedness, obligations
and liabilities of the Borrower to the Lender, now existing or hereafter incurred or arising, (hereinafter sometimes referred to as the “Obligations”), but excluding any obligations to Lender in its capacity as a holder of equity
securities of Borrower, the Borrower does hereby grant to the Lender a security interest in and to, and does hereby assign, pledge, transfer and convey to Lender, the property set forth on Exhibit A hereto, as such Exhibit shall be
supplemented from time to time, together with any and all additions and accessions thereto or replacements thereof and any products and/or proceeds of any of the foregoing (the “Collateral”). If, with respect to any Collateral in the form
of investment securities, a stock dividend is declared or any stock split-up made or right to subscribe issued, all the certificates for the shares representing such stock dividend or split-up or right to subscribe will be immediately delivered,
duly endorsed, to the Lender as additional Collateral. 
  
 The Lender shall have,
but shall not be limited to, the following rights, each of which may be exercised at any time or from time to time: (i) to transfer this Note and the Collateral, and any transferee shall have all the rights of the Lender hereunder and the Lender
shall be thereafter relieved from any liability with respect to any Collateral so transferred; and (ii) to vote any investment securities forming a part of the Collateral. 
  
  

 Borrower will at Lender’s request maintain insurance on the Collateral in amounts at least equal to the fair market
value of the Collateral and against casualty, public liability and property damage risks and such other risks as Lender may request. Borrower will pay all premiums for insurance when due. Unless and until requested by Lender, Borrower shall not be
required to name Lender as additional insured in such policy or to provide Lender a copy of the policy for or certificate evidencing such insurance, but when and if requested by Lender, the Borrower shall as promptly as reasonably practicable: (i)
cause all policies of such insurance to specify that Lender is an additional insured as its interests may appear and to provide that such insurance shall not be cancelable by Borrower or the insurer without at least 30 days advance written notice to
Lender and that proceeds are payable to Lender regardless of any act or omission of Borrower which would otherwise result in a denial of a claim; and (ii) deliver all policies or certificates thereof (with copies of such policies) to Lender. In the
event any or all of such insurance is cancelled, any returned premium thereon may be collected by Lender and applied by Lender to any part of the Obligations, either matured or unmatured. Lender is authorized to receive the proceeds of any insurance
loss and at the option of Lender shall apply such proceeds toward either the repair or replacement of the Collateral or the payment of the Obligations secured hereby. Borrower will also pay all taxes and other impositions on the Collateral as well
as the cost of repairs or maintenance to the Collateral. The loss, injury or destruction of the Collateral, with or without the fault of Borrower, shall not release the Borrower from any liability hereunder or in any way affect Borrower’s
liability hereunder. 
  
 The occurrence of any one or more of the following
conditions or events shall constitute an “Event of Default” hereunder: (i) any failure of Borrower to pay any of the Obligations when due or to observe or perform any agreement, covenant or promise hereunder; (ii) any default of Borrower
in the payment or performance of any other liabilities, indebtedness or obligations to Lender or to allow or permit any other liabilities, indebtedness or obligations to Lender to be accelerated; (iii) any failure of Borrower to observe or perform
any agreement, covenant or promise contained in any agreement, instrument or certificate executed in connection with the granting of a security interest in property to secure the Obligations; (iv) any warranty, representation or statement made or
furnished to the Lender by or on behalf of Borrower in connection with the loan evidenced by this Note proving to have been false in any material respect when made or furnished; (v) any loss, theft, substantial damage, destruction, sale, foreclosure
of or encumbrance to any of the Collateral, or the making of any levy, seizure or attachment thereof or thereon or the rendering of any judgment or lien or garnishment or attachment against Borrower; or (vi) the dissolution, liquidation or winding
up of Borrower, or the insolvency, or appointment of a receiver of any part of the property of, assignment for the benefit of creditors by, or the commencement of any proceeding under any bankruptcy or insolvency laws, state or federal, by or
against, the Borrower. 
  
 Upon the occurrence of an Event of Default (and the
expiration of any applicable notice and/or grace periods), to the extent permitted by law, the Lender at its option may declare all of the Obligations to be immediately due and payable, all without notice or demand, and shall have in addition to and
independent of the right to declare the Obligations to be due and payable and any other rights of the Lender under this Note or any other agreement with Borrower, the remedies of a secured party under the Uniform Commercial Code as in effect in
North Carolina (the “Code”), including, without limitation thereto, the right to take possession of the Collateral, or the proceeds thereof and to sell or otherwise dispose thereof, and for this purpose, to sign in the name of Borrower any
transfer, conveyance or instrument necessary or appropriate in order for the Lender to sell or dispose of any of the Collateral, and the Lender may, so far as the Borrower can give authority therefor, enter upon the premises on which the Collateral
or any part thereof may be situated and remove the same therefrom, without being liable in any way to Borrower on account of entering any premises. The Lender may require the Borrower to assemble the Collateral and make the Collateral available to
the Lender at a place to be designated by the Lender which is reasonably convenient to both parties. Unless the Collateral is perishable or threatens to decline speedily in value or is of a type customarily sold on a recognized market, the Lender
shall give the Borrower written notice of the time and place of any public sale thereof or of the time after which any private sale or other intended disposition thereof is to be made. The requirement of sending reasonable notice shall be met if
such notice is mailed, postage prepaid, or otherwise given, to the Borrower at the last address shown on the Lender’s records at least ten (10) days before such disposition. Lender shall comply with all applicable state or federal law
requirements in connection with a disposition of the Collateral. 
  
 The rights of
the Lender specified herein shall be in addition to, and not in limitation of, the Lender’s rights under the Code, or any other statute or rules of law conferring rights similar to those conferred by the Code, and under the provisions of any
other instrument or agreement executed by the Borrower to the Lender. All prior agreements to the extent inconsistent with the terms of this Note shall be construed in accordance with the provisions hereof. Any rights or remedies of the Lender may
be exercised or taken in any order or sequence whatsoever, at the sole option of the Lender. This agreement shall bind and inure to the benefit of the heirs, legatees, executors, administrators and assigns of Lender and Borrower. 
  
 The security agreement set forth herein and the security interest in the Collateral created
hereby shall terminate only when all of the Obligations have been paid in full. No waiver by the Lender of any default shall operate as a waiver of any other default or of the same default on a future occasion. All rights of the Lender hereunder
shall inure to the benefit of its successors and assigns, and all obligations of the Borrower shall bind the heirs, legal representatives, successors and assigns of the Borrower. Borrower and each endorser, surety or guarantor of this Note, whether
bound by this or by separate instrument or agreement, shall be jointly and severally liable for the indebtedness evidenced by this Note and hereby severally (i) waive presentment for payment, demand, protest, notice of nonpayment or dishonor and of
protest and any and all other notices and demands whatsoever; to the fullest extent permitted by applicable law; and (ii) consent that at any time, or from time to time, payment of any sum payable under this Note may be extended without notice
whether for a definite or indefinite time. The Borrower shall pay to Lender on demand all expenses, including reasonable attorneys’ fees and expenses, incurred by Lender in any way arising from or relating to the enforcement or attempted
enforcement of the Note and any related guaranty, collateral document or other document and the collection or attempted collection, whether by litigation or otherwise, of this Note. Time is of the essence. 
  
 This Note evidences the indebtedness heretofore evidenced by, and amends and restates in its
entirety, the Note and Security Agreement dated as of May 1, 2002 made by the Borrower in favor of the Lender. This Note is not in payment or satisfaction of the Note and Security Agreement dated as of May 1, 2002 nor is this Note in any way
intended to constitute a novation of the Note and Security Agreement dated as of May 1, 2002. 
  
 This Note, and the rights and obligations of the parties hereunder, shall be governed and construed in accordance with the laws of the State of North Carolina, except to the extent that the Code provides for the
application of other law with respect to the Collateral. 
  
 [Signature Page to Follow] 
  
  

 IN WITNESS WHEREOF, the Borrower and the Lender have executed this Note under seal the day and year set forth above.

  

									
	 	 	 	 	 Borrower:

			
	 Attest:
	 	 	 	 TARGACEPT, INC.

					
	 	 	 /s/    Alan A. Musso        
	 	 	 	By:	 	 /s/    J. Donald deBethizy        

	 	 	
	 	 	 	 	 	

	 Title:
	 	 VP & CFO
	 	 	 	 Title:
	 	 President & CEO

	 	 	
	 	 	 	 	 	

	 	 	 [Corporate Seal]
	 	 	 	 	 	 

  

									
	 	 	 	 	 Lender:

			
	 Attest:
	 	 	 	 R.J. REYNOLDS TOBACCO HOLDINGS, INC.

					
	 	 	 /s/    Daniel Fawley        
	 	 	 	By:	 	 /s/    Lynn L. Lane        

	 	 	
	 	 	 	 	 	

	 Title:
	 	 VP & Assistant Treasurer
	 	 	 	 Title:
	 	 SVP & Treasurer

	 	 	
	 	 	 	 	 	

	 	 	 [Corporate Seal]
	 	 	 	 	 	 

  
  

 Exhibit A 
  

 Appendix A 
  
 Loan Collateral Summary: 
  

						
	 2000 Post Spinout
	  	$	132,056.26	 	 
	 2001 Additions
	  	$	995,243.21	 	 
	 2002 Add-CIP
	  	$	1,290,937.55	 	includes some estimates
	 2002 Additions
	  	$	99,546.68	 	 
	 	  	
	
	 	 
	 	  	$	2,517,783.70	 	 
	 	  	
	
	 	 

  

 2000 Post Spinout 
  

				
	 9/30/2000 Laptop
	  	$	3,670.92
	 30-Sep Laptop
	  	$	4,176.30
	 30-Sep Laptop
	  	$	3,980.21
	 31-Oct Shredder
	  	$	4,125.62
	 20-Oct S/ware - Office Suite
	  	$	2,441.45
	 20-Oct 15 Dell pc’s
	  	$	25,440.97
	 20-Oct T-1
	  	$	3,879.28
	 20-Oct 26 MIS office 2000
	  	$	14,310.87
	 20-Oct NT Software
	  	$	3,964.22
	 20-Oct CISCO Switch, Tape Backup
	  	$	28,489.09
	 21-Nov Balance
	  	$	2,292.73
	 21-Nov Freezer
	  	$	1,805.81
	 21-Nov Balance
	  	$	1,144.85
	 22-Nov Epxon XGA
	  	$	5,099.34
	 13-Nov FAS software
	  	$	2,135.85
	 30-NovX10Giaga
	  	$	3,819.05
	 30-Nov PCI-Gigenet
	  	$	3,394.25
	 1-Dec IBM Thinkpad
	  	$	835.00
	 6-Dec 5 Dell monitors
	  	$	2,332.00
	 6-Dec 15 Dell workstations
	  	$	14,718.45
	 	  	
	

	 	  	$	132,056.26
	 	  	
	

  

 2001 Additions 
  

									
	DATE

	  	VENDOR

	  	 DESCRIPTION

	  	QUANTITY

	  	TOTAL

	 	  	 	  	DRUG DISCOVERY	  	 	  	 
	1/5/2001	  	Fisher	  	ROTVAPOR 24/40 R114A JCK/BTH	  	1	  	4,013.48
	3/14/2001	  	Gilson	  	215 LIQUID HANDLER	  	1	  	31,355.18
	3/24/2001	  	Phenomenex	  	RP 80A SYNERGY MAX	  	1	  	1,337.25
	 	  	 	  	Sales Tax	  	 	  	80.23
	3/27/2001	  	Fisher	  	R 200A ROT EVAP	  	1	  	3,695.72
	3/27/2001	  	Fisher	  	CATALYTIC PARR APPARATUS 115V 60HZ	  	1	  	2,777.33
	3/15/2001	  	Genevac	  	EVAPORATOR SYSTEM	  	1	  	31,650.00
	4/30/2001	  	Micromass	  	MASS SPEC UPGRADE/SYSTEM	  	1	  	25,948.80
	4/30/2001	  	Gilson	  	Compact Slave Pump/Cells	  	1	  	19,246.46
	5/31/2001	  	Isco	  	Separation System	  	1	  	18,993.08
	6/18/2001	  	VWR Scientific	  	Lg. Capacity Mixer	  	1	  	1,800.20
	8/7/2001	  	Fisher	  	Ref/Freezer115V	  	1	  	1,350.11
	9/30/2001	  	Fisher	  	Sonic Dismember Digital MDL 500	  	1	  	4,235.41
	11/30/2001	  	Waters	  	Mass Spec	  	1	  	149,542.55
	12/31/2001	  	Waters	  	2695 w/col htr/degas/sealwash	  	1	  	27,724.46
	 	  	 	  	 	  	 	  	

	 	  	 	  	 	  	 	  	323,750.26
	 	  	 	  	 	  	 	  	

	 	  	 	  	BIOLOGICAL SCIENCES	  	 	  	 
	1/16/2001	  	Brandel	  	HARVESTER (TTP-48 PROBE); #1FL	  	1	  	9,942.60
	 	  	 	  	VACUUM PUMP W/ MIST PUMP	  	1	  	 
	 	  	 	  	Sales Tax	  	1	  	596.55
	2/21/2001	  	Millipore	  	MILLI Q ACADEMIC 120V/60HZ	  	2	  	7,029.26
	 	  	 	  	Q-GARD 2	  	2	  	 
	 	  	 	  	QUANTUM EX	  	2	  	 
	 	  	 	  	PRESS REGULATOR W/GAUGE	  	2	  	 
	2/13/2001	  	Beckman Coulter	  	GRIPPER TOOL SYS FOR BIOMEK 2000	  	1	  	10,054.32
	 	  	 	  	96-FILTRATION SYSTEM	  	1	  	 
	3/14/2001	  	Brandel	  	1 BIT 48K PROBE	  	1	  	1,450.00
	3/27/2001	  	PerkinElmer	  	1450 TRILUX 23 NET 16 PLATE	  	1	  	81,166.69
	 	  	 	  	Sales Tax	  	 	  	4,869.99
	5/10/2001	  	Brandel	  	Supfrafusion 2500	  	1	  	34,324.74
	6/30/2001	  	Carmet	  	Beckman J2-s1M	  	1	  	6,200.00
	 	  	 	  	Beckman JA20	  	1	  	1,700.00
	6/30/2001	  	VWR Scientific	  	Generator PTA107S	  	1	  	1,128.11
	7/31/2001	  	Inotech	  	Pressure Plate Inserts	  	var	  	2,970.00
	8/24/2001	  	Inotech	  	3300 Harvester Pump	  	1	  	1,365.00
	 	  	 	  	 	  	 	  	

	 	  	 	  	 	  	 	  	162,797.26
	 	  	 	  	 	  	 	  	

  
  

 2001 Additions 
  

									
	 	  	 	  	 	  	 	  	—  

	 	  	 	  	 	  	 	  	486,547.52
	 	  	 	  	 	  	 	  	

	3/27/2001	  	 Apple Rock
	  	 Trade Show Display Board (Deposit)
	  	1	  	865.80
	4/30/2001	  	 Apple Rock
	  	 Trade Show Display Board (Bal)
	  	1	  	1,140.89
	7/27/2001	  	 ARM
	  	 Contract Tickler System
	  	1	  	4,529.00
	9/30/2001	  	 Best SW
	  	 FAS Suite/Cradle
	  	1	  	4,095.78
	10/25/2001	  	 Hodges
	  	 FAS Upgrade to Network
	  	1	  	3,042.16
	 	  	 	  	 	  	 	  	

	 	  	 	  	 	  	 	  	13,673.63
	 	  	 	  	 	  	 	  	

	1/11/2001	  	 GraphPAd
	  	 PRISM FOR WINDOWS
	  	3	  	1,113.75
	 	  	 Silicon
	  	 REMFGD 195MHZ 1P OCTANE SI
	  	 	  	 
	12/15/2001	  	 Graphics
	  	 128MB/4G
	  	2	  	10,286.34
	 	  	 	  	 DESTN KIT PERIPHERALS 115V
	  	4	  	 
	 	  	 	  	 ADVANCED WKST EVIRONMENT 6.5
	  	2	  	 
	 	  	 	  	 REMFGD 21" G1 DISPLAY OCTANE
	  	2	  	 
	 	  	 	  	 KEYBOARD KIT US 02 AND OCTANE
	  	2	  	 
	 	  	 	  	 DELL GX100 600MHZ CELERON
	  	 	  	 
	2/19/2001	  	 NetUnlimited
	  	 PROCESSOR W/128MB RAM
	  	5	  	8,364.70
	 	  	 	  	 DELL PRECISION 330 1.3 GHZ
	  	 	  	 
	 	  	 	  	 PROCESSOR W/256MB RAM
	  	1	  	 
	2/5/2001	  	 NetUnlimited
	  	 LASERJET 2100TN INTERNAL NIC
	  	1	  	1,187.20
	 	  	 	  	 LASERJET 2100TN TONER CARTIDGE
	  	1	  	 
	 	  	 	  	 HEWLETT PACKARD LASERJET 2100TN
	  	 	  	 
	2/8/2001	  	 NetUnlimited
	  	 INTERNAL NIC
	  	2	  	2,194.20
	3/27/2001	  	 NetUnlimited
	  	 Dell 420 Workstation
	  	1	  	3,457.00
	3/27/2001	  	 NetUnlimited
	  	 Sony VAIO/HP Scanjet
	  	1	  	3,346.71
	5/10/2001	  	 Silicon
	  	 PCI CARD CAGE
	  	2	  	3,180.00
	5/31/2001	  	 NetUnlimited
	  	 Dell Pwer App Web 120 PIII
	  	1	  	3,198.02
	 	  	 	  	 Dell Optiplex GX 110 PIII
	  	4	  	4,405.36
	6/18/2001	  	 NetUnlimited
	  	 6 deLL Optiplex GX110 Computers
	  	6	  	6,604.04
	 	  	 	  	 4 Dell P78017" Color Monitor
	  	4	  	1,394.96
	7/27/2001	  	 G.Dunbar
	  	 Laptop
	  	1	  	3,669.97
	10/24/2001	  	 D. Lambe
	  	 Laptop
	  	1	  	3.417.78
	 	  	 NuGenesis
	  	 Software-Unify & Vision Software Licenses,
	  	 	  	 
	12/31/2001	  	 Tech.
	  	 Archive Software License
	  	 	  	125,443.60
	12/31/2001	  	 IBM
	  	 X Series 330 P111 1U Server
	  	3	  	21,518.00
	 	  	 	  	 	  	 	  	

	 	  	 	  	 	  	 	  	202,781.63
	 	  	 	  	 	  	 	  	

	 	  	 	  	 PENTAD HARDWARE
	  	 	  	 
	4/30/2001	  	 RCH Products
	  	 Zappa Computer
	  	1	  	265,906.50
	6/18/2001	  	 NetUnlimited
	  	 Zappa Wiring
	  	 	  	713.56
	9/30/2001	  	 RCH Products
	  	 Octane R12k, Octane R10k, Software Care
	  	 	  	11,694.18
	 	  	 	  	 	  	 	  	

	 	  	 	  	 	  	 	  	278,314.24
	 	  	 	  	 	  	 	  	

	 	  	 	  	 PENTAD SOFTWARE
	  	 	  	 
	04/30/001	  	 Harcourt
	  	 	  	 	  	13,526.19
	 	  	 Serena
	  	 	  	 	  	400.00
	 	  	 	  	 	  	 	  	

	 	  	 	  	 	  	 	  	13,926.19
	 	  	 	  	 	  	 	  	

	 	  	 	  	 	  	 	  	995,243.21
	 	  	 	  	 	  	 	  	

  
  

 2002 CIP 
  

						
	 Cold Room
	  	$	48,234.00	 	 
	 Animal Housing System
	  	$	50,967.50	 	 
	 Furniture & Fixtures
	  	$	773,697.13	 	 
	 Artwork
	  	$	20,849.55	 	 
	 Signs
	  	$	14,226.00	 	 
	 Leasehold Improvements
	  	$	78,404.58	 	 
	 IT Switches/Communications
	  	$	106,679.96	 	 
	 Stability Chambers
	  	$	39,112.17	 	 
	 Estimates:

	  	 	 	 	 
	 Cage Wash System
	  	$	35,766.66	 	Final bills not received
	 AV Equipment
	  	$	115,000.00	 	Final bills not received
	 Additional Furniture Pieces
	  	$	8,000.00	 	Final bills not received
	 	  	
	
	 	 
	 	  	$	1,290,937.55	 	 
	 	  	
	
	 	 

  

 2002 Additions 
  

									
	 	  	 	  	MEDICINAL CHEMISTRY	  	 	  	 
	3/20/2002	  	 Fisher
	  	 Mettler Toledo Analytical Balance Model AB204-
	  	1	  	2,276.23
	2/28/2002	  	 Insight
	  	 HP Laserjet 1200
	  	3	  	1,137.00
	 	  	 	  	 	  	 	  	

	 	  	 	  	Total Med Chem	  	 	  	3,413.23
	 	  	 	  	 	  	 	  	

	 	  	 	  	 P3
	  	 	  	 
	1/31/2002	  	 Fisher
	  	 Cold Trap Condenser Assembly
	  	1	  	25,973.48
	2/5/2002	  	 Aetrohm- Pea
	  	 Metrohm-Peak Personal IC System
	  	1	  	18,186.22
	 	  	 	  	 	  	 	  	

	 	  	 	  	 Total P3
	  	 	  	44,159.70
	 	  	 	  	 	  	 	  	

	 	  	 	  	BIOLOGICAL SCIENCES	  	 	  	 
	3/20/2002	  	 Brandel
	  	 BR-36 Auto Dispensing System; 2X1B
	  	1	  	3,850.00
	3/20/2002	  	 Brandel
	  	 18 Channel Perfusion Block, Tray, Reagent
	  	1	  	6,650.00
	3/20/2002	  	 VWR
	  	 Balance Basic 1510G CAPX10MG
	  	2	  	3,147.63
	 	  	 	  	 	  	 	  	

	 	  	 	  	Total Biological Sciences	  	 	  	13,647.63
	 	  	 	  	 	  	 	  	

	 	  	 	  	Total Drug Discovery & Biological Sciences	  	 	  	57,807.33
	 	  	 	  	 	  	 	  	

	 	  	 	  	Administrative	  	 	  	 
	1/31/2002	  	 Dell
	  	 Latitude C810,1.13Ghz, Pentium III
	  	1	  	3,135.37
	3/31/2002	  	 Dell
	  	 Laptop
	  	 	  	3,153.49
	 	  	 	  	 	  	 	  	

	 	  	 	  	Total Administrative	  	 	  	6,288.86
	 	  	 	  	 	  	 	  	

	 	  	 	  	 IT
	  	 	  	 
	1/31/2002	  	 NuGenesis
	  	 Instrument Archive Server
	  	1	  	23,787.50
	2/27/2002	  	 Insight
	  	 Netshelter VX Base Enclosure
	  	1	  	1,569.00
	2/27/2002	  	 Dell
	  	 PC’s
	  	3	  	3,527.27
	 	  	 	  	 	  	 	  	

	 	  	 	  	Total IT	  	 	  	28,883.77
	 	  	 	  	 	  	 	  	

	 	  	 	  	Clinical Research & Development	  	 	  	 
	2/27/2002	  	 Dell
	  	 Laptop
	  	 	  	3,153.49
	 	  	 	  	 	  	 	  	

	 	  	 	  	Total Clinical Research & Development	  	 	  	3,153.49
	 	  	 	  	 	  	 	  	

	 	  	 	  	Total New Additions	  	 	  	99,546.68
	 	  	 	  	 	  	 	  	

  
  

 Amended and Restated Note and Security Agreement of 
 Targacept, Inc. in favor of R.J. Reynolds Tobacco Holdings, Inc. dated January 30,2004 
  
 Form of Supplemental Schedule to Exhibit A 
  
 Additional Collateral: 
  
 Attach spreadsheet including, without limitation: 
  

1. Number of Additional Tranche 
  
 2. Date of Additional Tranche 
  
 3. Interest Rate Applicable to Additional Tranche 
  
 4. First Payment of Additional Tranche Due 
  
 5. Last Payment of
Additional Tranche Due 
  
 6. Amount of Each Monthly Payment in respect of
Additional Tranche 
  
 7. Aggregate Amount of Each Monthly Payment in respect of
all Tranches 
  
 8. Aggregate Principal Amount Outstanding on all Tranches

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00066-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00066-of-00352.parquet"}]]