Document:

EX-10.1

 Exhibit 10.1 

Execution Version 
  

 
  

FOURTH AMENDMENT 

TO THE 

CREDIT AGREEMENT 

dated as of April 13, 2016 

among 

ENERGEN CORPORATION, 

as Borrower, 

WELLS FARGO BANK, NATIONAL ASSOCIATION, 

as Administrative Agent, 

THE GUARANTOR SIGNATORY HERETO, 

and 
 THE
LENDERS SIGNATORY HERETO 
  

 
  

 FOURTH AMENDMENT TO 

CREDIT AGREEMENT 

This FOURTH AMENDMENT TO THE CREDIT AGREEMENT (this
“Fourth Amendment”), dated as of April 13, 2016 (the “Fourth Amendment Effective Date”), is among ENERGEN CORPORATION, a corporation formed under the laws of the State of Alabama
(“Borrower”); the undersigned guarantor (the “Guarantor”, and together with Borrower, the “Credit Parties”); each of the Lenders party hereto; and WELLS FARGO
BANK, NATIONAL ASSOCIATION, as administrative agent for the Lenders (in such capacity, together with its successors in such capacity, “Administrative Agent”). 

Recitals 
 A. Borrower,
Administrative Agent and the Lenders are parties to that certain Credit Agreement dated as of September 2, 2014 (as heretofore amended, modified, supplemented or restated, the “Credit Agreement”), pursuant to which the Lenders
have, subject to the terms and conditions set forth therein, made certain credit available to and on behalf of Borrower. 
 B. The parties
hereto desire to enter into this Fourth Amendment to amend the Credit Agreement as set forth herein. 
 C. The Lenders party hereto also
desire to complete the April 1, 2016 Scheduled Redetermination as set forth herein. 
 NOW, THEREFORE, in consideration of the premises
and the mutual covenants herein contained, for good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto agree as follows: 

Section 1. Defined Terms. Each capitalized term which is defined in the Credit Agreement, but which is not defined in this Fourth
Amendment, shall have the meaning ascribed to such term in the Credit Agreement (as amended hereby). Unless otherwise indicated, all section references in this Fourth Amendment refer to the Credit Agreement. 

Section 2. Amendments to Credit Agreement. In reliance on the representations, warranties, covenants and agreements contained in
this Fourth Amendment, and subject to the satisfaction of the conditions precedent set forth in Section 4 hereof, the Credit Agreement is hereby amended, effective as of the Fourth Amendment Effective Date, as follows: 

2.1 Amendments to Section 1.02. 

(a) Each of the following definitions set forth in Section 1.02 is amended and restated in its entirety to read as follows: 

“Defaulting Lender” means, subject to Section 2.11(b), any Lender that (a) has failed
to (i) fund its pro rata share of any Loans or participation in Letters of Credit required to be funded by it hereunder within two (2) Business Days of the date required to be funded by it 

  
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hereunder or (ii) pay to the Administrative Agent, the Issuing Bank, the Swingline Lender or any other Lender any other amount required to be paid by it hereunder (including in respect of
its participation in Letters of Credit and Swingline Loans) within two (2) Business Days of the date when due, (b) has notified the Borrower, the Administrative Agent or the Issuing Bank or Swingline Lender in writing that it does not
intend to comply with its funding obligations hereunder, or has made a public statement to that effect, (c) has failed, within three (3) Business Days after written request by the Administrative Agent or the Borrower, to confirm in writing
to the Administrative Agent and the Borrower that it will comply with its prospective funding obligations hereunder (provided that such Lender shall cease to be a Defaulting Lender pursuant to this clause (c) upon receipt of such written
confirmation by the Administrative Agent and the Borrower), or (d) has, or has a direct or indirect parent company that has, (i) become the subject of a proceeding under any Debtor Relief Law, (ii) had appointed for it a receiver,
custodian, conservator, trustee, administrator, or assignee for the benefit of creditors or similar Person charged with reorganization or liquidation of its business or assets, including the Federal Deposit Insurance Corporation or any other state
or federal regulatory authority acting in such a capacity or (iii) become the subject of a Bail-In Action; provided that a Lender shall not be a Defaulting Lender solely by virtue of the ownership or acquisition of any Equity Interest in
that Lender or any direct or indirect parent company thereof by a Governmental Authority so long as such ownership interest does not result in or provide such Lender with immunity from the jurisdiction of courts within the United States or from the
enforcement of judgments or writs of attachment on its assets or permit such Lender (or such Governmental Authority) to reject, repudiate, disavow or disaffirm any contracts or agreements made with such Lender. Any determination by the
Administrative Agent that a Lender is a Defaulting Lender under clauses (a) through (d) above shall be conclusive and binding absent manifest error, and such Lender shall be deemed to be a Defaulting Lender upon delivery of written notice
of such determination to the Borrower, the Issuing Bank, the Swingline Lender and each other Lender. 
 “LC
Commitment” at any time means Fifty Million dollars ($50,000,000). 
 (b) Each of the following definitions is added to
Section 1.02 in the appropriate alphabetical order: 
 “Bail-In Action” means the exercise of
any Write-Down and Conversion Powers by the applicable EEA Resolution Authority in respect of any liability of an EEA Financial Institution. 

“Bail-In Legislation” means, with respect to any EEA Member Country implementing Article 55 of
Directive 2014/59/EU of the 

  
 2 

 
European Parliament and of the Council of the European Union, the implementing law for such EEA Member Country from time to time which is described in the EU Bail-In Legislation Schedule. 

“EEA Financial Institution” means (a) any credit institution or investment firm established in any
EEA Member Country which is subject to the supervision of an EEA Resolution Authority, (b) any entity established in an EEA Member Country which is a parent of an institution described in clause (a) of this definition, or (c) any
financial institution established in an EEA Member Country which is a subsidiary of an institution described in clauses (a) or (b) of this definition and is subject to consolidated supervision with its parent. 

“EEA Member Country” means any of the member states of the European Union, Iceland, Liechtenstein, and
Norway. 
 “EEA Resolution Authority” means any public administrative authority or any person
entrusted with public administrative authority of any EEA Member Country (including any delegee) having responsibility for the resolution of any EEA Financial Institution. 

“EU Bail-In Legislation Schedule” means the EU Bail-In Legislation Schedule published by the Loan
Market Association (or any successor person), as in effect from time to time. 
 “Write-Down and Conversion
Powers” means, with respect to any EEA Resolution Authority, the write-down and conversion powers of such EEA Resolution Authority from time to time under the Bail-In Legislation for the applicable EEA Member Country, which write-down
and conversion powers are described in the EU Bail-In Legislation Schedule. 
 2.2 Amendment to Section 2.07(e).
Section 2.07(e) is amended by replacing the reference to “April 1, 2016” appearing in clause (y) of the third sentence of Section 2.07(e), with “October 1, 2016”. 

2.3 Amendment to Section 2.11(a)(iv). The second sentence of Section 2.11(a)(iv) Agreement is amended and restated in its
entirety to read as follows: 
 Subject to Section 12.19, no reallocation hereunder shall constitute a waiver or
release of any claim of any party hereunder against a Defaulting Lender arising from that Lender having become a Defaulting Lender, including any claim of a Non-Defaulting Lender as a result of such Non-Defaulting Lender’s increased exposure
following such reallocation. 

  
 3 

 2.4 Amendments to Section 9.12. Section 9.12 is amended by (a) replacing
the period at the end of subsection (j) with “; and” and (b) adding the following new clause (k) to read in its entirety as follows: 

(k) the sale or other disposition of all or a portion of the Oil and Gas Properties described on Schedule 9.12(k);
provided that (i) such sale or other disposition is consummated prior to the delivery of the New Borrowing Base Notice for the Scheduled Redetermination scheduled to occur on or about October 1, 2016, (ii) no Default, Event of
Default or Borrowing Base Deficiency exists before or after giving effect to such sale or other disposition and (iii) the consideration received in respect of such sale or other disposition shall be equal to or greater than the fair market
value of such Oil and Gas Properties sold or otherwise disposed of (as reasonably determined by a Responsible Officer of the Borrower and, if requested by the Administrative Agent, the Borrower shall deliver a certificate of a Responsible Officer of
the Borrower certifying to that effect). 
 2.5 Amendment to Article XII. Article XII of the Credit Agreement is amended by adding a
new Section 12.19 to read in full as follows: 
 Section 12.19 Acknowledgement and Consent to Bail-In of EEA
Financial Institutions. Notwithstanding anything to the contrary in any Loan Document or in any other agreement, arrangement or understanding among any such parties, each party hereto acknowledges that any liability of any EEA Financial
Institution arising under any Loan Document, to the extent such liability is unsecured, may be subject to the write-down and conversion powers of an EEA Resolution Authority and agrees and consents to, and acknowledges and agrees to be bound by:

 (a) the application of any Write-Down and Conversion Powers by an EEA Resolution Authority to any such liabilities arising
hereunder which may be payable to it by any party hereto that is an EEA Financial Institution; and 
 (b) the effects of any
Bail-in Action on any such liability, including, if applicable: 
 (i) a reduction in full or in part or cancellation of any
such liability; 
 (ii) a conversion of all, or a portion of, such liability into shares or other instruments of ownership
in such EEA Financial Institution, its parent undertaking, or a bridge institution that may be issued to it or otherwise conferred on it, and that such shares or other instruments of ownership will be accepted by it in lieu of any rights with
respect to any such liability under this Agreement or any other Loan Document; or 
 (iii) the variation of the terms of
such liability in connection with the exercise of the write-down and conversion powers of any EEA Resolution Authority. 

  
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 2.6 Amendment to Schedules. The Credit Agreement is hereby amended by adding a new
Schedule 9.12(k) in the form attached hereto as Schedule 9.12(k). 
 Section 3. Borrowing Base Redetermination; Reduction of
Aggregate Commitment. 
 3.1 Subject to the satisfaction of the conditions precedent set forth in Section 4 hereof,
Administrative Agent and the Lenders hereby agree that for the period from and including the Fourth Amendment Effective Date to but excluding the next Redetermination Date, the amount of the Borrowing Base shall be equal to $1,050,000,000 (the
“April 2016 Redetermination”). Administrative Agent, the Lenders and Borrower agree that the foregoing constitutes the April 1, 2016 Scheduled Redetermination and that this Fourth Amendment shall constitute the New Borrowing
Base Notice with respect to such Scheduled Redetermination. Notwithstanding the foregoing, the Borrowing Base may be subject to further redeterminations and adjustments from time to time pursuant to Section 2.07 or Section 8.12(c).
Notwithstanding anything to the contrary set forth in Section 2.07, the parties agree that the Oil and Gas Properties described on Schedule 9.12(k) are not included in the April 2016 Redetermination. 

3.2 Concurrently with the April 2016 Redetermination, the Aggregate Commitment shall be reduced (ratably among the Lenders in accordance with
each Lender’s Applicable Percentage) pursuant to Section 2.06(b)(iii), so that the Aggregate Commitment equals $1,050,000,000 (and Annex I is hereby deemed amended to reflect the reduction to each Lender’s Commitment and the Aggregate
Commitment). 
 Section 4. Conditions Precedent. The effectiveness of this Fourth Amendment is subject to the following: 

4.1 Administrative Agent shall have received counterparts of this Fourth Amendment from the Credit Parties, the Required Lenders and the
Issuing Bank. 
 4.2 Administrative Agent shall have received such other documents as Administrative Agent or special counsel to
Administrative Agent may reasonably request. 
 Administrative Agent shall notify Borrower and the Lenders of the effectiveness of this Fourth Amendment,
and such notice shall be conclusive and binding. 

  
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 Section 5. Representations and Warranties; Etc. Each Credit Party hereby affirms:
(a) that as of the date hereof, the representations and warranties of Borrower and Guarantor set forth in each Loan Document are true and correct in all material respects (or, if qualified by materiality or Material Adverse Effect, in all
respects), except to the extent any such representations and warranties are expressly limited to an earlier date, in which case, on and as of the date hereof, such representations and warranties continue to be true and correct in all material
respects (or, if qualified by materiality or Material Adverse Effect, in all respects) as of such specified earlier date and (b) that as of the date hereof, no Default or Event of Default has occurred and is continuing or would result from this
Fourth Amendment. 
 Section 6. Miscellaneous. 

6.1 Confirmation and Effect. The provisions of the Credit Agreement (as amended by this Fourth Amendment) shall remain in full force
and effect in accordance with its terms following the effectiveness of this Fourth Amendment. Each reference in the Credit Agreement to “this Agreement”, “hereunder”, “hereof”, “herein”, or words of like
import shall mean and be a reference to the Credit Agreement as amended hereby, and each reference to the Credit Agreement in any other document, instrument or agreement executed and/or delivered in connection with the Credit Agreement shall mean
and be a reference to the Credit Agreement as amended hereby. The execution, delivery and effectiveness of this Fourth Amendment shall not, except as expressly provided herein, operate as a waiver of any right, power or remedy of any Lender or the
Administrative Agent under any of the Loan Documents, nor constitute a waiver of any provision of any of the Loan Documents. 
 6.2
Ratification and Affirmation of Credit Parties. Each of the Credit Parties hereby expressly (a) acknowledges the terms of this Fourth Amendment, (b) ratifies and affirms its obligations under the Guaranty Agreement and the other
Loan Documents to which it is a party, (c) acknowledges, renews and extends its continued liability under the Guaranty Agreement and the other Loan Documents to which it is a party (in each case, as amended hereby), and (d) acknowledges
and confirms that the amendments contemplated hereby shall not limit or impair any Liens securing the Indebtedness, each of which are hereby ratified, affirmed and extended to secure the Indebtedness after giving effect to this Fourth Amendment.

 6.3 Counterparts. This Fourth Amendment may be executed by one or more of the parties hereto in any number of separate
counterparts, and all of such counterparts taken together shall be deemed to constitute one and the same instrument. Delivery of this Fourth Amendment by facsimile or electronic (e.g. pdf) transmission shall be effective as delivery of a manually
executed original counterpart hereof. 
 6.4 No Oral Agreement. This written Fourth Amendment, the Credit Agreement and the other
Loan Documents executed in connection herewith and therewith represent the final agreement between the parties and may not be contradicted by evidence of prior, contemporaneous, or unwritten oral agreements of the parties. There are no subsequent
oral agreements between the parties. 

  
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 6.5 Governing Law. This Fourth Amendment (including, but not limited to, the validity and
enforceability hereof) shall be governed by, and construed in accordance with, the laws of the State of New York. 
 6.6
Severability. Any provision of this Fourth Amendment which is prohibited or unenforceable in any jurisdiction shall, as to such jurisdiction, be ineffective to the extent of such prohibition or unenforceability without invalidating the
remaining provisions hereof, and any such prohibition or unenforceability in any jurisdiction shall not invalidate or render unenforceable such provision in any other jurisdiction. 

6.7 Loan Document. This Fourth Amendment shall constitute a “Loan Document” for all purposes under the other Loan Documents.

 [signature pages follow] 

  
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 IN WITNESS WHEREOF, the parties hereto have caused this Fourth Amendment to be duly executed effective as of the
date first written above. 
  

							
	BORROWER:	 		 	ENERGEN CORPORATION
				
		 		 	By:	 	 /S/ CHARLES W. PORTER, JR.

		 		 	Name:	 	Charles W. Porter, Jr.
		 		 	Title:	 	Vice President, Chief Financial Officer and Treasurer
			
	GUARANTOR:	 		 	ENERGEN RESOURCES CORPORATION
				
		 		 	By:	 	 /S/ CHARLES W. PORTER, JR.

		 		 	Name:	 	Charles W. Porter, Jr.
		 		 	Title:	 	Vice President, Chief Financial Officer and Treasurer

  
 [SIGNATURE
PAGE] 
 [FOURTH AMENDMENT TO THE CREDIT
AGREEMENT] 
 [ENERGEN CORPORATION] 

							
	ADMINISTRATIVE AGENT:	 		 	WELLS FARGO BANK, NATIONAL ASSOCIATION,
		 		 	as Administrative Agent, Issuing Bank and Lender
				
		 		 	By:	 	 /s/ Lila Jordan

		 		 	Name:	 	Lila Jordan
		 		 	Title:	 	Managing Director

  
 [SIGNATURE
PAGE] 
 [FOURTH AMENDMENT TO THE CREDIT
AGREEMENT] 
 [ENERGEN CORPORATION] 

							
	SYNDICATION AGENT:	 		 	BANK OF AMERICA, N.A.,
			
		 		 	as Syndication Agent and Lender
				
		 		 	By:	 	 /s/ Ronald E. McKaig

		 		 	Name:	 	Ronald E. McKaig
		 		 	Title:	 	Managing Director

  
 [SIGNATURE
PAGE] 
 [FOURTH AMENDMENT TO THE CREDIT
AGREEMENT] 
 [ENERGEN CORPORATION] 

							
	CO-DOCUMENTATION AGENT:	 		 	COMPASS BANK,
			
		 		 	as Co-Documentation Agent and Lender
				
		 		 	By:	 	 /s/ Blake Kirshman

		 		 	Name:	 	Blake Kirshman
		 		 	Title:	 	Senior Vice President

  
 [SIGNATURE
PAGE] 
 [FOURTH AMENDMENT TO THE CREDIT
AGREEMENT] 
 [ENERGEN CORPORATION] 

							
	CO-DOCUMENTATION AGENT:	 		 	JPMORGAN CHASE BANK, N.A.,
			
		 		 	as Co-Documentation Agent and Lender
				
		 		 	By:	 	 /s/ Jo Linda Papadakis

		 		 	Name:	 	Jo Linda Papadakis
		 		 	Title:	 	Authorized Officer

  
 [SIGNATURE
PAGE] 
 [FOURTH AMENDMENT TO THE CREDIT
AGREEMENT] 
 [ENERGEN CORPORATION] 

							
	CO-DOCUMENTATION AGENT:	 		 	REGIONS BANK,
		 		 	as Co-Documentation Agent and Lender
				
		 		 	By:	 	 /s/ William A. Philipp

		 		 	Name:	 	William A. Philipp
		 		 	Title:	 	Managing Director

  
 [SIGNATURE
PAGE] 
 [FOURTH AMENDMENT TO THE CREDIT
AGREEMENT] 
 [ENERGEN CORPORATION] 

							
	LENDERS:	 		 	MUFG UNION BANK, N.A.,
		 		 	as Lender
				
		 		 	By:	 	 /s/ Mark Oberreuter

		 		 	Name:	 	Mark Oberreuter
		 		 	Title:	 	Vice President

  
 [SIGNATURE
PAGE] 
 [FOURTH AMENDMENT TO THE CREDIT
AGREEMENT] 
 [ENERGEN CORPORATION] 

 
			
	CIBC Inc.,
	as Lender
		
	By:	 	 /s/ Daria Mahoney

	Name:	 	Daria Mahoney
	Title:	 	Authorized Signatory
		
	By:	 	 /s/ Richard Antl

	Name:	 	Richard Antl
	Title:	 	Authorized Signatory

  
 [SIGNATURE
PAGE] 
 [FOURTH AMENDMENT TO THE CREDIT
AGREEMENT] 
 [ENERGEN CORPORATION] 

 
			
	MIZUHO BANK, LTD.,
	as Lender
		
	By:	 	 /s/ Leon Mo

	Name:	 	Leon Mo
	Title:	 	Authorized Signatory

  
 [SIGNATURE
PAGE] 
 [FOURTH AMENDMENT TO THE CREDIT
AGREEMENT] 
 [ENERGEN CORPORATION] 

 
			
	 PNC BANK, NATIONAL ASSOCIATION,
 as
Lender

		
	By:	 	 /s/ John Engel

	Name:	 	John Engel
	Title:	 	Vice President

  
 [SIGNATURE
PAGE] 
 [FOURTH AMENDMENT TO THE CREDIT
AGREEMENT] 
 [ENERGEN CORPORATION] 

 
			
	SUMITOMO MITSUI BANKING CORPORATION,
	as Lender
		
	By:	 	 /s/ James D. Weinstein

	Name:	 	James D. Weinstein
	Title:	 	Managing Director

  
 [SIGNATURE
PAGE] 
 [FOURTH AMENDMENT TO THE CREDIT
AGREEMENT] 
 [ENERGEN CORPORATION] 

 
			
	U.S. BANK NATIONAL ASSOCIATION,
	as Lender
		
	By:	 	 /s/ Nicholas T. Hanford

	Name:	 	Nicholas T. Hanford
	Title:	 	Vice President

  
 [SIGNATURE
PAGE] 
 [FOURTH AMENDMENT TO THE CREDIT
AGREEMENT] 
 [ENERGEN CORPORATION] 

 
			
	BRANCH BANKING AND TRUST COMPANY,
	as Lender
		
	By:	 	 /s/ Ryan Aman

	Name:	 	Ryan Aman
	Title:	 	Vice President

  
 [SIGNATURE
PAGE] 
 [FOURTH AMENDMENT TO THE CREDIT
AGREEMENT] 
 [ENERGEN CORPORATION] 

 
			
	BMO HARRIS BANK N. A.,
	as Lender
		
	By:	 	 /s/ Melissa Guzmann

	Name:	 	Melissa Guzmann
	Title:	 	Vice President

  
 [SIGNATURE
PAGE] 
 [FOURTH AMENDMENT TO THE CREDIT
AGREEMENT] 
 [ENERGEN CORPORATION] 

 
			
	DNB CAPITAL LLC,
	as Lender
		
	By:	 	 /s/ Asulv Tveit

	Name:	 	Asulv Tveit
	Title:	 	First Vice President
		
	By:	 	 /s/ Mack Lambert

	Name:	 	Mack Lambert
	Title:	 	Vice President

  
 [SIGNATURE
PAGE] 
 [FOURTH AMENDMENT TO THE CREDIT
AGREEMENT] 
 [ENERGEN CORPORATION] 

 
			
	ROYAL BANK OF CANADA,
	as Lender
		
	By:	 	 /s/ Kristan Spivey

	Name:	 	Kristan Spivey
	Title:	 	Authorized Signatory

  
 [SIGNATURE
PAGE] 
 [FOURTH AMENDMENT TO THE CREDIT
AGREEMENT] 
 [ENERGEN CORPORATION] 

 
			
	THE TORONTO DOMINION (NEW YORK) LLC,
	as Lender
		
	By:	 	 /s/ Annie Dorval

	Name:	 	Annie Dorval
	Title:	 	Authorized Signatory

  
 [SIGNATURE
PAGE] 
 [FOURTH AMENDMENT TO THE CREDIT
AGREEMENT] 
 [ENERGEN CORPORATION] 

 
			
	BOKF, NA DBA BANK OF OKLAHOMA,
	as Lender
		
	By:	 	 /s/ John Krenger

	Name:	 	John Krenger
	Title:	 	Vice President

  
 [SIGNATURE
PAGE] 
 [FOURTH AMENDMENT TO THE CREDIT
AGREEMENT] 
 [ENERGEN CORPORATION] 

 
			
	CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH,
	as Lender
		
	By:	 	 /s/ Nupur Kumar

	Name:	 	Nupur Kumar
	Title:	 	Authorized Signatory
		
	By:	 	 /s/ Nicholas Goss

	Name:	 	Nicholas Goss
	Title:	 	Authorized Signatory

  
 [SIGNATURE
PAGE] 
 [FOURTH AMENDMENT TO THE CREDIT
AGREEMENT] 
 [ENERGEN CORPORATION] 

 
			
	FIFTH THIRD BANK,
	as Lender
		
	By:	 	 /s/ Larry Hayes

	Name:	 	Larry Hayes
	Title:	 	Director

  
 [SIGNATURE
PAGE] 
 [FOURTH AMENDMENT TO THE CREDIT
AGREEMENT] 
 [ENERGEN CORPORATION] 

 
			
	SYNOVUS BANK,
	as Lender
		
	By:	 	 /s/ Joseph Keener

	Name:	 	Joseph Keener
	Title:	 	Senior Vice President

  
 [SIGNATURE
PAGE] 
 [FOURTH AMENDMENT TO THE CREDIT
AGREEMENT] 
 [ENERGEN CORPORATION] 

 
			
	BARCLAYS BANK PLC,
	as Lender
		
	By:	 	 /s/ Vanessa Kurbatskiy

	Name:	 	Vanessa Kurbatskiy
	Title:	 	Vice President

  
 [SIGNATURE
PAGE] 
 [FOURTH AMENDMENT TO THE CREDIT
AGREEMENT] 
 [ENERGEN CORPORATION] 

 
			
	MORGAN STANLEY BANK, N. A.,
	as Lender
		
	By:	 	 /s/ Andrew Mellgard

	Name:	 	Andrew Mellgard
	Title:	 	Authorized Signatory

  
 [SIGNATURE
PAGE] 
 [FOURTH AMENDMENT TO THE CREDIT
AGREEMENT] 
 [ENERGEN CORPORATION] 

 SCHEDULE 9.12(k) 

Sales Pursuant To Section 9.12(k) 

Those certain Oil and Gas Properties in the file named “DB - Bank_3-3-16_.zip” posted to the Energen Corporation 09/14 Syndtrak site on
March 25, 2016 that can be accessed by changing the Select, Sort, Total Instructions in such file from “RA; RA_SELL_KEEP; is Null” to “RA; RA_SELL_KEEP; Sale”.EX-10.1

 Exhibit 10.1 

SECURITIES PURCHASE AGREEMENT 
 THIS
SECURITIES PURCHASE AGREEMENT (the “Agreement”), dated as of April 12, 2016, by and among CareDx, Inc., a Delaware corporation with headquarters located at 3260 Bayshore Boulevard, Brisbane, California 94005 (the
“Company”), and the investors listed on the Schedule of Investors attached hereto as Exhibit A (individually, an “Investor” and collectively, the “Investors”). 

BACKGROUND 
 A. Each
Investor, severally and not jointly, wishes to purchase, and the Company wishes to sell, upon the terms and conditions stated in this Agreement, the number of units (“Units”) set forth opposite such Investor’s name on
Exhibit A hereto, each such Unit is comprised of the following securities of the Company: (i) one share (the “Common Shares”) of common stock of the Company, par value $0.001 per share (the “Common
Stock”); (ii) five shares (the “Preferred Shares”) Series A Mandatorily Convertible Preferred Stock of the Company, par value $0.001 per share that is mandatorily convertible upon receipt by the Company of Stockholder
Approval into Common Stock in accordance with the terms and conditions of the Certificate of Designation in the form attached as Exhibit B hereto (with such other changes as are mutually agreed by the parties hereto) (the “Certificate
of Designation”); and (iii) three warrants, in substantially the form attached hereto as Exhibit G, each to purchase one share of Common Stock (the “Warrants”), to acquire up to that number of additional shares
of Common Stock upon exercise of such Warrants set forth opposite such Investor’s name on Exhibit A (the shares of Common Stock issuable upon mandatory conversion of the Preferred Shares, collectively, the “Underlying Preferred
Shares” and the shares of Common Stock issuable upon exercise of or otherwise pursuant to the Warrants, collectively, the “Warrant Shares”). 

B. The Company and each Investor are executing and delivering this Agreement in reliance upon the exemption from registration afforded by
Section 4(a)(2) of the Securities Act of 1933, as amended (the “Securities Act”), and Rule 506(b) of Regulation D (“Regulation D”) as promulgated by the United States Securities and Exchange Commission (the
“SEC”) under the Securities Act. 
 C. The Common Shares, Preferred Shares, Underlying Preferred Shares, the Warrants and
the Warrant Shares issued to the Investors pursuant to this Agreement are collectively referred to herein as the “Securities.” 

NOW, THEREFORE, IN CONSIDERATION of the mutual covenants contained in this Agreement, and for other good and valuable consideration the
receipt and adequacy of which are hereby acknowledged, the Company and the Investors agree as follows: 

 ARTICLE I 

DEFINITIONS 
 1.1
Definitions. In addition to the terms defined elsewhere in this Agreement, the following terms have the meanings indicated: 

“Additional Filing Date” means the later of (i) the date sixty (60) days after the date substantially all of the
Registrable Securities registered under the immediately preceding Registration Statement are sold and (ii) the date six (6) months from the Effective Date of the immediately preceding Registration Statement, or, if such date is not a
Business Day, the next date that is a Business Day. 
 “Additional Registration Statement” has the meaning set forth in
Section 6.1(a). 
 “Additional Required Effectiveness Date” means the date which is the earliest of (i) if
the Registration Statement does not become subject to review by the SEC, (a) sixty (60) days after the Additional Filing Date or (b) five (5) Trading Days after the Company receives notification from the SEC that the Additional
Registration Statement will not become subject to review and the Company fails to request to accelerate the effectiveness of the Registration Statement, or (ii) if the Additional Registration Statement becomes subject to review by the SEC,
ninety (90) days after the Additional Filing Date, or, if such date is not a Business Day, the next date that is a Business Day. 

“Affiliate” means any Person that, directly or indirectly through one or more intermediaries, controls or is controlled by or
is under common control with a Person, as such terms are used in and construed under Rule 144 under the Securities Act. 

“Agents” has the meaning set forth in Section 3.1(l). 

“Agreement” has the meaning set forth in the Preamble. 

“Allenex Offer” shall mean the offer being made by the Company to purchase all of the outstanding shares of Allenex AB
pursuant to the Offer Document, dated March 7, 2016, as amended, and the related purchase agreements to acquire, subject to certain conditions, approximately 78% of the outstanding shares of Allenex AB from its three principal shareholders in
exchange for a combination of cash and Common Stock. 
 “Business Day” means any day other than Saturday, Sunday or other
day on which commercial banks in the City of New York are authorized or required by law to remain closed. 
 “Closing”
means the closing of the purchase and sale of the Securities pursuant to Section 2.1. 
 “Closing Date” means
the date and time of the Closing and shall be 11:00 a.m., New York City time, on April 15, 2016 or such earlier date and time as all of the conditions specified in Article 5 have been satisfied or waived. 

  
 2 

 “Closing Price” means, for any date, the closing price per share of the Common
Stock for such date (or, if such date is not a Trading Day, the nearest preceding date that is a Trading Day) on the primary Eligible Market or exchange or quotation system on which the Common Stock is then listed or quoted. 

“Commitment Letters” mean those certain Commitment Letters entered into between the Company and each stockholder (each a
“Commitment Stockholder” and collectively, the “Commitment Stockholders”) named therein pursuant to which the Commitment Stockholders have committed to investing in aggregate at least $8 million in a subsequent
financing by the Company on terms, including price, substantially equivalent to the terms of the Units. 
 “Company” has
the meaning set forth in the Preamble. 
 “Company Counsel” means Wilson Sonsini Goodrich & Rosati, Professional
Corporation, counsel to the Company. 
 “Common Shares” has the meaning set forth in the Preamble. 

“Common Stock” has the meaning set forth in the Preamble. 

“Common Stock Equivalents” means, collectively, Options and Convertible Securities. 

“Contingent Obligation” has the meaning set forth in Section 3.1(cc). 

“Convertible Securities” means any stock or securities (other than Options) convertible into or exercisable or exchangeable
for Common Stock. 
 “Disclosure Materials” has the meaning set forth in Section 3.1(g). 

“Effective Date” means the date that a Registration Statement is first declared effective by the SEC. 

“Effectiveness Period” has the meaning set forth in Section 6.1(b). 

“8-K Filing” has the meaning set forth in Section 4.5. 

“Eligible Market” means any of The New York Stock Exchange, Inc., The NYSE MKT LLC, The NASDAQ Global Select Market, the
NASDAQ Global Market or The NASDAQ Capital Market. 
 “Enforceability Exceptions” means (i) applicable bankruptcy,
insolvency, reorganization, moratorium or other laws of general application relating to or affecting the enforcement of creditors rights generally, and (ii) the effect of rules of law governing the availability of specific performance,
injunctive relief and other equitable remedies. 
 “Environmental Laws” has the meaning set forth in
Section 3.1(gg). 
 “Escrow Account” has the meaning set forth in Section 2.2(b). 

  
 3 

 “Escrow Agent” means ServisFirst Bank, an Alabama state chartered bank. 

“Event” has the meaning set forth in Section 6.1(d). 

“Event Payments” has the meaning set forth in Section 6.1(d). 

“Exchange Act” means the Securities Exchange Act of 1934, as amended. 

“Excluded Events” has the meaning set forth in Section 6.1(d)(ii). 

“Excluded Investors” means Leerink Partners LLC, M.M. Dillon & Co. and Brookline Capital Markets, a division of CIM
Securities, LLC, and their respective Affiliates. 
 “Filing Date” means the Initial Filing Date and the Additional Filing
Date, as applicable. 
 “GAAP” has the meaning set forth in Section 3.1(g). 

“Hazardous Materials” has the meaning set forth in Section 3.1(gg). 

“Indebtedness” has the meaning set forth in Section 3.1(dd). 

“Indemnified Party” has the meaning set forth in Section 6.4(c). 

“Indemnifying Party” has the meaning set forth in Section 6.4(c). 

“Initial Filing Date” means 45 days after the Closing Date or, if such date is not a Business Day, the next date that is a
Business Day. 
 “Initial Registration Statement” has the meaning set forth in Section 6.1(a). 

“Initial Required Effectiveness Date” means the date which is the earliest of (i) if the Registration Statement does not
become subject to a full review by the SEC, (a) ninety (90) days after the Closing Date or (b) five (5) Trading Days after the Company receives notification from the SEC that the Registration Statement will not become subject to
review and the Company fails to request to accelerate the effectiveness of the Registration Statement, or (ii) if the Registration Statement becomes subject to a full review by the SEC, one hundred and twenty (120) days after the Closing
Date, or, if such date is not a Business Day, the next date that is a Business Day. 
 “Intellectual Property Rights” has
the meaning set forth in Section 3.1(v). 
 “Lien” means any lien, charge, claim, security interest,
encumbrance, right of first refusal or other restriction. 
 “Losses” means any and all losses, claims, damages,
liabilities, settlement costs and expenses, including, without limitation reasonable attorneys’ fees. 
 “Material Adverse
Effect” means (i) a material adverse effect on the condition (financial or otherwise), results of operations, assets, business or prospects of the Company and the Subsidiaries, 

  
 4 

 
taken as a whole, or (ii) a material and adverse impairment of the Company’s ability to perform its obligations under any of the Transaction Documents, provided that none of the
following alone shall be deemed, in and of itself, to constitute a Material Adverse Effect: (i) a change in the market price or trading volume of the Common Stock or (ii) changes in general economic conditions or changes affecting the
industry in which the Company operates general (as opposed to Company-specific changes) so long as such changes do not have a disproportionate effect on the Company and its Subsidiaries, taken as a whole. 

“Material Permits” has the meaning set forth in Section 3.1(x). 

“Preferred Shares” has the meaning set forth in the Preamble. 

“Options” means any outstanding rights, warrants or options to subscribe for or purchase Common Stock or Convertible
Securities. 
 “Person” has the meaning set forth in Section 3.1(dd). 

“Pledge” has the meaning set forth in Section 4.1(c). 

“Proceeding” means an action, claim, suit, investigation or proceeding (including, without limitation, a partial proceeding,
such as a deposition), whether commenced or threatened in writing. 
 “Prospectus” means the prospectus included in the
Registration Statement (including, without limitation, a prospectus that includes any information previously omitted from a prospectus filed as part of an effective registration statement in reliance upon Rule 430A promulgated under the Securities
Act), as amended or supplemented by any prospectus supplement, with respect to the terms of the offering of any portion of the Registrable Securities covered by the Registration Statement, and all other amendments and supplements to the Prospectus
including post-effective amendments, and all material incorporated by reference or deemed to be incorporated by reference in such Prospectus. 

“Registrable Securities” means the Common Shares, the Underlying Preferred Shares and the Warrant Shares issued or issuable
pursuant to the Transaction Documents, without taking into account any securities issued or issuable upon any stock split, dividend or other distribution, recapitalization or similar event with respect to the foregoing. 

“Registration Statement” means each registration statement required to be filed under Article VI, including the Initial
Registration Statement, all Additional Registration Statements, and, in each case, the Prospectus, amendments and supplements to such registration statement or Prospectus, including pre- and post-effective amendments, all exhibits thereto, and all
material incorporated by reference or deemed to be incorporated by reference in such registration statement. 
 “Required
Effectiveness Date” means the Initial Required Effectiveness Date and the Additional Required Effectiveness Date, as applicable. 

“Rule 144,” “Rule 415,” and “Rule 424” means Rule 144, Rule 415 and Rule 424, respectively,
promulgated by the SEC pursuant to the Securities Act, as such Rules may be amended from time to time, or any similar rule or regulation hereafter adopted by the SEC having substantially the same effect as such Rule. 

  
 5 

 “Schedules” has the meaning set forth in Section 3.1. 

“SEC” has the meaning set forth in the Preamble. 

“Securities” has the meaning set forth in the Preamble. 

“Securities Act” has the meaning set forth in the Preamble. 

“SEC Reports” has the meaning set forth in Section 3.1(g). 

“Short Sales” has the meaning set forth in Section 3.2(i). 

“Stockholder Approval” has the meaning set forth in Certificate of Designation. 

“Stockholder Approval Date” has the meaning set forth in Section 4.9. 

“Stockholder Meeting” has the meaning set forth in Section 4.9. 

“Stockholder Meeting Deadline” has the meaning set forth in Section 4.9. 

“Stockholder Resolutions” has the meaning set forth in Section 4.9. 

“Subsidiary” means any Significant Subsidiary (which for purposes of this Agreement has the meaning ascribed to such term in
Regulation S-X under the Exchange Act) of the Company. 
 “Trading Day” means (a) any day on which the Common Stock is
listed or quoted and traded on its primary Trading Market, or (b) if the Common Stock is not then listed or quoted and traded on its primary Trading Market, then a day on which trading of the Common Stock occurs on an Eligible Market, or
(c) if the Common Stock is not listed or quoted as set forth in clauses (a) or (b) hereof, any Business Day. 

“Trading Market” means The NASDAQ Global Select Market or any other Eligible Market, or any national securities exchange,
market or trading or quotation facility on which the Common Stock is then listed or quoted. 
 “Transaction Documents”
means this Agreement, the schedules and exhibits attached hereto, the Warrants and the Transfer Agent Instructions. 
 “Transfer
Agent” means ComputerShare Trust Company, N.A. or any successor transfer agent for the Company. 
 “Transfer Agent
Instructions” means, with respect to the Company, the Irrevocable Transfer Agent Instructions, in the form of Exhibit F, executed by the Company and delivered to and acknowledged in writing by the Transfer Agent. 

  
 6 

 “Underlying Preferred Shares” has the meaning set forth in the Preamble. 

“Units” has the meaning set forth in the Preamble. 

“Voting Agreement” has the meaning set forth in Section 5.1(c). 

“Voting Stockholders” has the meaning set forth in Section 5.1(c). 

“Warrants” has the meaning set forth in the Preamble. 

“Warrant Shares” has the meaning set forth in the Preamble. 

ARTICLE II 
 PURCHASE AND SALE 

2.1 Closing. Subject to the terms and conditions set forth in this Agreement, at the Closing the Company shall issue and sell to each
Investor, and each Investor shall, severally and not jointly, purchase from the Company, the number of Units set forth opposite such Investor’s name on Exhibit A hereto under the heading “Units” for the price set forth opposite
such Investor’s name on Exhibit A hereto under the heading “Purchase Price”. The date and time of the Closing and shall be 11:00 a.m., New York City time, on the Closing Date. The Closing shall take place at the offices of the
Company Counsel. 
 2.2 Closing Deliveries. 

(a) At the Closing, the Company shall deliver or cause to be delivered to each Investor the following: 

(i) one or more stock certificates (or copies thereof provided by the Transfer Agent), free and clear of all restrictive and other legends
(except as expressly provided in Section 4.1(b) hereof), evidencing such number of Common Shares set forth opposite such Investor’s name on Exhibit A hereto under the heading “Common Shares”, registered in the name
of such Investor (or its designee); 
 (ii) one or more stock certificates (or copies thereof provided by the Transfer Agent), free and
clear of all restrictive and other legends (except as expressly provided in Section 4.1(b) hereof), evidencing such number of Preferred Shares set forth opposite such Investor’s name on Exhibit A hereto under the heading
“Preferred Shares”, registered in the name of such Investor (or its designee); 
 (iii) a Warrant, free and clear of all
restrictive and other legends (except as expressly provided in Section 4.1(b) hereof), pursuant to which such Investor shall have the right to acquire such number of Warrant Shares set forth opposite such Investor’s name on
Exhibit A hereto under the heading “Warrant Shares,” registered in the name of such Investor (or its designee); 

  
 7 

 (iv) a legal opinion of Company Counsel, in the form of Exhibit D, executed by such
counsel and delivered to the Investors and the Agents; 
 (v) approval by each applicable Trading Market of an additional shares listing
application covering all of the Registrable Securities; 
 (vi) a certificate evidencing the good standing of the Company issued by the
Secretary of State of the State of Delaware, as of a date within three (3) Business Days of the Closing Date; 
 (vii) a certificate
signed by its Chief Executive Officer or its Chief Financial Officer, dated as of the Closing Date, certifying to the fulfillment of the Company conditions specified in Sections 5.1(a) and (b). 

(viii) a certificate of the Secretary of the Company, dated as of the Closing Date, (a) certifying the resolutions adopted by the Board
of Directors of the Company or a duly authorized committee thereof approving the transactions contemplated by this Agreement and the other Transaction Documents and the issuance of the Securities, (b) certifying the current versions of the
certificate of incorporation, as amended, and by-laws of the Company and (c) certifying as to the signatures and authority of persons signing the Transaction Documents and related documents on behalf of
the Company. 
 (b) Prior to or at the Closing, each Investor shall deliver or cause to be delivered to the Escrow Agent the purchase price
set forth opposite such Investor’s name on Exhibit A hereto under the heading “Purchase Price” in United States dollars for such Investor’s Units and in immediately available funds, by wire transfer to the following
deposit account (the “Escrow Account”): 
 Beneficiary Bank and Address: 

ServisFirst Bank 
 850 Shades Creek Parkway, Suite 200 

Birmingham, AL 35209 
 ABA number: 

062006505 
 Bank Contact: 

Stacie Stephenson 
 205.949.0319 

Beneficiary Name: 
 CareDx, Inc. 

ServisFirst Bank as Escrow Agent 
 Beneficiary Account Number:

 1110275524 
 Each disbursement of any such funds
deposited into the Escrow Account shall be made in accordance with the Escrow Agreement, dated April 8, 2016, between ServisFirst Bank and the Company, and this Agreement. 

  
 8 

 ARTICLE III 

REPRESENTATIONS AND WARRANTIES 

3.1 Representations and Warranties of the Company. Except as disclosed in the corresponding section of the Schedules hereto (the
“Schedules”), which Schedules shall be deemed a part hereof, the Company hereby represents and warrants to the Investors and the Agents as follows (which representations and warranties shall be deemed to apply, where appropriate, to
each Subsidiary of the Company): 
 (a) Subsidiaries. The Company has no Subsidiaries other than those listed in
Schedule 3.1(a) hereto. Except as disclosed in Schedule 3.1(a) hereto, the Company owns, directly or indirectly, all of the capital stock or comparable equity interests of each Subsidiary free and clear of any Lien, all the issued and
outstanding shares of capital stock or comparable equity interest of each Subsidiary are validly issued and are fully paid, non-assessable and free of preemptive and similar rights. 

(b) Organization and Qualification. Except as disclosed in Schedule 3.1(b), each of the Company and the
Subsidiaries is an entity duly organized, validly existing and in good standing under the laws of the jurisdiction of its incorporation or organization (as applicable), with the requisite corporate authority to own and use its properties and assets
and to carry on its business as currently conducted. Neither the Company nor any Subsidiary is in violation of any of the provisions of its respective certificate or articles of incorporation, bylaws or other organizational or charter documents.
Except as disclosed in Schedule 3.1(b), each of the Company and the Subsidiaries is duly qualified to do business and is in good standing as a foreign corporation or other entity in each jurisdiction in which the nature of the business
conducted or property owned by it makes such qualification necessary, except where the failure to be so qualified or in good standing, as the case may be, would not, individually or in the aggregate, have or reasonably be expected to result in a
Material Adverse Effect. 
 (c) Authorization; Enforcement of Transaction Documents and Commitment Letters. The
Company has the requisite corporate authority to enter into and to consummate the transactions contemplated by each of the Transaction Documents to which it is a party and otherwise to carry out its obligations hereunder and thereunder. The
execution and delivery of each of the Transaction Documents to which it is a party by the Company and the consummation by it of the transactions contemplated hereby and thereby have been duly authorized by all necessary corporate action on the part
of the Company and no further consent or action is required by the Company, its Board of Directors or its stockholders other than obtaining Stockholder Approval. Each of the Transaction Documents to which it is a party has been (or upon delivery
will be) duly executed by the Company and is, or when delivered in accordance with the terms hereof, will constitute, the valid and binding obligation of the Company enforceable against the Company in accordance with its terms, except as may be
limited by Enforceability Exceptions. The Company has the requisite corporate authority to enter into and to consummate the transactions contemplated by the Commitment Letters and to carry out its obligations thereunder. The execution and delivery
of the Commitment Letters by the Company and 

  
 9 

 
the consummation of the transactions contemplated by the Company have been duly authorized by all necessary corporate action on the part of the Company and no further consent or action is
required by the Company, its Board of Directors or its stockholders. The Commitment Letters will be duly executed by the Company and is, or when delivered in accordance with the terms hereof, will constitute, the valid and binding obligation of the
Company enforceable against the Company in accordance with its terms, except as may be limited by Enforceability Exceptions. 

(d) No Conflicts. The execution, delivery and performance of the Transaction Documents to which it is a party by the
Company and the consummation by the Company of the transactions contemplated hereby and thereby do not, and will not, (i) conflict with or violate any provision of the Company’s or any Subsidiary’s certificate or articles of
incorporation, bylaws or other organizational or charter documents, (ii) conflict with, or constitute a default (or an event that with notice or lapse of time or both would become a default) under, or give to others any rights of termination,
amendment, acceleration or cancellation (with or without notice, lapse of time or both) of, any agreement, credit facility, debt or other instrument (evidencing a Company or Subsidiary debt or otherwise) or other understanding to which the Company
or any Subsidiary is a party or by which any property or asset of the Company or any Subsidiary is bound, or affected, except to the extent that such conflict, default, termination, amendment, acceleration or cancellation right would not reasonably
be expected to have a Material Adverse Effect, or (iii) to the Company’s knowledge, result in a violation of any law, rule, regulation, order, judgment, injunction, decree or other restriction of any court or governmental authority to
which the Company or any Subsidiary is subject (including, assuming the accuracy of the representations and warranties of the Investors set forth in Section 3.2 hereof, federal and state securities laws and regulations and the rules and
regulations of any self-regulatory organization to which the Company or its securities are subject, including all applicable Trading Markets), or by which any property or asset of the Company or any Subsidiary is bound or affected, except to the
extent that such violation would not reasonably be expected to have a Material Adverse Effect. 
 (e) The Securities.
The Securities are duly authorized and, when issued and paid for in accordance with the Transaction Documents and upon receipt of Stockholder Approval in the case of the Underlying Preferred Shares and Warrant Shares, will be duly and validly
issued, fully paid and nonassessable, free and clear of all Liens and will not be subject to preemptive or similar rights of stockholders (other than those imposed by the Investors). The Company has reserved from its duly authorized capital stock
the maximum number of shares of Warrant Shares issuable upon exercise of the Warrants, without taking into account any limitations on exercise of the Warrants and the maximum number of Underlying Preferred Shares. The offer, issuance and sale of the
Securities are exempt from the registration requirements of the Securities Act. 
 (f) Capitalization. The aggregate
number of shares and type of all authorized, issued and outstanding classes of capital stock, options and other securities of the Company (whether or not presently convertible into or exercisable or exchangeable for shares of capital stock of the
Company) is set forth in Schedule 3.1(f) hereto. All 

  
 10 

 
outstanding shares of capital stock are duly authorized, validly issued, fully paid and nonassessable and have been issued in compliance in all material respects with all applicable securities
laws. Except as disclosed in Schedule 3.1(f) hereto, the Company did not have outstanding at March 31, 2016 any other options, warrants, script rights to subscribe to, calls or commitments of any character whatsoever relating to, or
securities, rights or obligations convertible into or exercisable or exchangeable for, or entered into any agreement giving any Person any right to subscribe for or acquire, any shares of Common Stock, or securities or rights convertible or
exchangeable into shares of Common Stock. Except as set forth on Schedule 3.1(f) hereto, and except for customary adjustments as a result of stock dividends, stock splits, combinations of shares, reorganizations, recapitalizations,
reclassifications or other similar events, there are no anti-dilution or price adjustment provisions contained in any security issued by the Company (or in any agreement providing rights to security holders) and the issuance and sale of the
Securities will not obligate the Company to issue shares of Common Stock or other securities to any Person (other than the Investors) and will not result in a right of any holder of securities to adjust the exercise, conversion, exchange or reset
price under such securities. To the knowledge of the Company, except as disclosed in the SEC Reports and any Schedules filed with the SEC pursuant to Rule 13d-1 of the Exchange Act by reporting persons or in Schedule 3.1(f) hereto, no Person
or group of related Persons beneficially owns (as determined pursuant to Rule 13d-3 under the Exchange Act), or has the right to acquire, by agreement with or by obligation binding upon the Company, beneficial ownership of in excess of 5% of the
outstanding Common Stock. 
 (g) SEC Reports. The Company has filed all reports required to be filed by it under the
Exchange Act, including pursuant to Section 13(a) or 15(d) thereof, for the twenty-four (24) months preceding the date hereof on a timely basis or has received a valid extension of such time of filing and has filed any such SEC Reports
prior to the expiration of any such extension and has filed all reports required to be filed by it under the Exchange Act, including pursuant to Section 13(a) or 15(d) thereof, for the twenty-four months preceding the date hereof. Such reports
required to be filed by the Company under the Exchange Act, including pursuant to Section 13(a) or 15(d) thereof, together with any materials filed or furnished by the Company under the Exchange Act, whether or not any such reports were
required being collectively referred to herein as the “SEC Reports” and, together with this Agreement and the Schedules to this Agreement, the “Disclosure Materials”. As of their respective dates, the SEC Reports
filed by the Company complied in all material respects with the requirements of the Securities Act and the Exchange Act and the rules and regulations of the SEC promulgated thereunder, and none of the SEC Reports, when filed by the Company,
contained any untrue statement of a material fact or omitted to state a material fact required to be stated therein or necessary in order to make the statements therein, in the light of the circumstances under which they were made, not misleading.
The financial statements of the Company included in the SEC Reports comply in all material respects with applicable accounting requirements and the rules and regulations of the SEC with respect thereto as in effect at the time of filing. Such
financial statements have been prepared in accordance in all material respects with United States generally accepted accounting principles applied on a consistent basis during the periods involved (“GAAP”), except as may be
otherwise specified in such financial statements, the 

  
 11 

 
notes thereto and except that unaudited financial statements may not contain all footnotes required by GAAP or may be condensed or summary statements, and fairly present in all material respects
the consolidated financial position of the Company and its consolidated Subsidiaries as of and for the dates thereof and the results of operations and cash flows for the periods then ended, subject, in the case of unaudited statements, to normal,
year-end audit adjustments. All material agreements to which the Company or any Subsidiary is a party or to which the property or assets of the Company or any Subsidiary are subject are included as part of or identified in the SEC Reports, to the
extent such agreements are required to be included or identified pursuant to the rules and regulations of the SEC. 
 (h)
Financial Statements Since the date of the latest audited financial statements included within the SEC Reports, except as disclosed in the SEC Reports or in Schedule 3.1(h) hereto, (i) there has been no event, occurrence or
development that, individually or in the aggregate, has had or that would result in a Material Adverse Effect, (ii) the Company has not incurred any material liabilities other than (A) trade payables and accrued expenses incurred in the
ordinary course of business consistent with past practice and (B) liabilities not required to be reflected in the Company’s financial statements pursuant to GAAP or required to be disclosed in filings made with the SEC, (iii) the
Company has not altered its method of accounting or the changed its auditors, except as disclosed in its SEC Reports, (iv) the Company has not declared or made any dividend or distribution of cash or other property to its stockholders, in their
capacities as such, or purchased, redeemed or made any agreements to purchase or redeem any shares of its capital stock (except for repurchases by the Company of shares of capital stock held by employees, officers, directors, or consultants pursuant
to an option of the Company to repurchase such shares upon the termination of employment or services), and (v) the Company has not issued any equity securities to any officer, director or Affiliate, except pursuant to existing Company
stock-based plans. The Company has not taken any steps to seek protection pursuant to any bankruptcy law nor does the Company have any knowledge or reason to believe that its creditors intend to initiate involuntary bankruptcy proceedings or any
actual knowledge of any fact which would reasonably lead a creditor to do so. 
 (i) Absence of Litigation. Except as
disclosed in the SEC Reports, there is no action, suit, claim, or Proceeding, or, to the Company’s knowledge, inquiry or investigation, before or by any court, public board, government agency, self-regulatory organization or body pending or, to
the knowledge of the Company, threatened against or affecting the Company or any of its Subsidiaries that could, individually or in the aggregate, have a Material Adverse Effect. 

(j) Compliance. Except as described in Schedule 3.1(j), neither the Company nor any Subsidiary, except in each
case as would not, individually or in the aggregate, reasonably be expected to have or result in a Material Adverse Effect, (i) is in default under or in violation of (and no event has occurred that has not been waived that, with notice or
lapse of time or both, would result in a default by the Company or any Subsidiary under), nor has the Company or any Subsidiary received written notice of a claim that it is in default under or that it is in violation of, any indenture, loan or
credit agreement or any other agreement or instrument to which it is a party or by which it or any 

  
 12 

 
of its properties is bound (whether or not such default or violation has been waived), (ii) is in violation of any order of any court, arbitrator or governmental body, or (iii) is or
has been in violation of any statute, rule or regulation of any governmental authority. 
 (k) Title to Assets. The
Company and the Subsidiaries have good and marketable title to all real property owned by them that is material to the business of the Company and the Subsidiaries have good and marketable title in all personal property owned by them that is
material to the business of the Company and the Subsidiaries, in each case free and clear of all Liens, except for Liens that do not, individually or in the aggregate, have or result in a Material Adverse Effect. To the Company’s knowledge, any
real property and facilities held under lease by the Company and the Subsidiaries are held by them under valid, subsisting and enforceable leases of which the Company and the Subsidiaries are in material compliance. 

(l) No General Solicitation; Placement Agents’ Fees. Neither the Company, nor any of its Affiliates, nor any Person
acting on its or their behalf, has engaged in any form of general solicitation or general advertising (within the meaning of Regulation D) in connection with the offer or sale of the Securities. The Company shall be responsible for the payment
of any placement agent’s fees, financial advisory fees, or brokers’ commission (other than for persons engaged by any Investor or its investment advisor) relating to or arising out of the issuance of the Securities pursuant to this
Agreement. The Company shall pay, and hold each Investor harmless against, any liability, loss or expense (including, without limitation, reasonable and documented attorney’s fees and out-of-pocket expenses) arising in connection with any such
claim for fees arising out of the issuance of the Securities pursuant to this Agreement. The Company acknowledges that it has engaged Leerink Partners LLC, M.M. Dillon & Co. and Brookline Capital Markets, a division of CIM Securities, LLC,
as its lead placement agents and Reedland Capital Partners as its co-placement agent (collectively, the “Agents”) in connection with the sale of the Securities. Other than the Agents, the Company has not engaged any placement agent
or other agent in connection with the sale of the Securities. 
 (m) Rule 506 Compliance. To the Company’s
knowledge, the Company is not disqualified from relying on Rule 506 of Regulation D under the Securities Act (“Rule 506”) for any of the reasons stated in Rule 506(d) in connection with the issuance and sale of the Common Shares,
Preferred Shares and the Warrants to the Investor pursuant to this Agreement. The Company has exercised reasonable care, including without limitation, conducting a factual inquiry that is appropriate in light of the circumstances, into whether any
such disqualification under Rule 506(d) exists. The Company has furnished to each Investor, a reasonable time prior to the date hereof, a description in writing of any matters that would have triggered disqualification under Rule 506(d) but which
occurred before September 23, 2013, in each case, in compliance with the disclosure requirements of Rule 506(e). The Company has exercised reasonable care, including without limitation, conducting a factual inquiry that is appropriate in light
of the circumstances, into whether any such disqualification under Rule 506(d) would have existed and whether any disclosure is required to be made to Investor under Rule 506(e). 

  
 13 

 (n) Private Placement. Neither the Company nor any of its Affiliates nor,
any Person acting on the Company’s behalf has, directly or indirectly, at any time within the past six months, made any offer or sale of any security or solicitation of any offer to buy any security under circumstances that would
(i) eliminate the availability of the exemption from registration under Regulation D under the Securities Act in connection with the offer and sale by the Company of the Securities as contemplated hereby or (ii) cause the offering of
the Securities pursuant to the Transaction Documents to be integrated with prior offerings by the Company for purposes of any applicable law, regulation or stockholder approval provisions, including, without limitation, under the rules and
regulations of any Trading Market. Subject to the Company obtaining Stockholder Approval in accordance with the provisions of Section 4.9, the sale and issuance of the Securities hereunder does not contravene the rules and regulation of
any applicable Trading Market on which the Common Stock is listed or quoted. 
 (o) Investment Act. The Company is not
required to be registered as, and is not an Affiliate of, an “investment company” within the meaning of the Investment Company Act of 1940, as amended. 

(p) Form S-3 Eligibility. The Company is eligible to register the Common Shares, the Underlying Preferred Shares and the
Warrant Shares for resale by the Investors using Form S-3 promulgated under the Securities Act. 
 (q) Listing and
Maintenance Requirements. The Company has not, in the twenty-four (24) months preceding the date hereof, received notice (written or oral) from any Trading Market on which the Common Stock is or has been listed or quoted to the effect that
the Company is not in compliance with the listing or maintenance requirements of such Trading Market. The Company is in compliance in all material respects with all such listing and maintenance requirements. 

(r) Registration Rights. Except as described in Schedule 3.1(r), the Company has not granted or agreed to grant
to any Person any rights (including “piggy-back” registration rights) to have any securities of the Company registered with the SEC or any other governmental authority that have not been satisfied or waived. 

(s) Application of Takeover Protections. There is no control share acquisition, business combination, poison pill
(including any distribution under a rights agreement) or other similar anti-takeover provision under the Company’s charter documents or the laws of its state of incorporation that is or could become applicable to any of the Investors as a
result of the Investors and the Company fulfilling their obligations or exercising their rights under the Transaction Documents, including, without limitation, as a result of the Company’s issuance of the Securities and the Investors’
ownership of the Securities. 
 (t) Disclosure. Except for any information provided to an Investor pursuant to a
specific written due diligence request by such Investor to receive material nonpublic information, the Company confirms that neither it nor any officers, directors or Affiliates, 

  
 14 

 
has provided any of the Investors (other than Excluded Investors) or their agents or counsel with any information that constitutes or might constitute material, nonpublic information (other than
the existence and terms of the issuance of Securities, as contemplated by this Agreement). The Company understands and confirms that each of the Investors will rely on the foregoing representations in effecting transactions in securities of the
Company (other than Excluded Investors). All disclosure provided by the Company to the Investors regarding the Company, its business and the transactions contemplated hereby, including the Schedules to this Agreement, furnished by or on the behalf
of the Company are true and correct in all material respects and do not contain any untrue statement of a material fact or omit to state any material fact necessary in order to make the statements made therein, in the light of the circumstances
under which they were made, not misleading. Except for the transactions contemplated by this Agreement, no event or circumstance has occurred or information exists with respect to the Company or any of its Subsidiaries or its or their business,
properties, operations or financial condition, which, under applicable law, rule or regulation, requires public disclosure or announcement by the Company but which has not been so publicly announced or disclosed. The Company acknowledges and agrees
that no Investor (other than Excluded Investors) makes or has made any representations or warranties with respect to the transactions contemplated hereby other than those set forth in the Transaction Documents. 

(u) Acknowledgment Regarding Investors’ Purchase of Securities. Based upon the assumption that the transactions
contemplated by this Agreement are consummated in all material respects in conformity with the Transaction Documents, the Company acknowledges and agrees that each of the Investors (other than Excluded Investors) is acting solely in the capacity of
an arm’s length purchaser with respect to the Transaction Documents and the transactions contemplated hereby and thereby. The Company further acknowledges that no Investor (other than Excluded Investors) is acting as a financial advisor or
fiduciary of the Company (or in any similar capacity) with respect to this Agreement and the transactions contemplated hereby and any advice given by any Investor (other than Excluded Investors) or any of their respective representatives or agents
in connection with the Transaction Documents and the transactions contemplated hereby and thereby is merely incidental to the Investors’ purchase of the Securities. The Company further represents to each Investor that the Company’s
decision to enter into this Agreement has been based solely on the independent evaluation of the transactions contemplated hereby by the Company and its representatives. 

(v) Patents and Trademarks. The Company and its Subsidiaries own or possess or can obtain on commercially reasonable
terms adequate rights or licenses to use, all trademarks, trade names, service marks, service mark registrations, service names, patents, patent rights, copyrights, inventions, licenses, approvals, governmental authorizations, trade secrets and
other intellectual property rights (“Intellectual Property Rights”) necessary to conduct their respective businesses now conducted, except for such failures to own or possess as would not be reasonably expected to have a Material
Adverse Effect. Except as set forth in Schedule 3.1(v), none of the Company’s Intellectual Property Rights have expired or terminated, or are expected to expire or terminate, within three years from the date of this Agreement, other than
any expiration or termination that would 

  
 15 

 
not reasonably be expected to result in a Material Adverse Effect. The Company does not have any knowledge of any infringement by the Company or its Subsidiaries of Intellectual Property Rights
of others. Except as disclosed in the SEC Reports, there is no claim, action or proceeding being made or brought, or to the knowledge of the Company, being threatened, against the Company or its Subsidiaries regarding its Intellectual Property
Rights, except for such claim, action or proceedings as would not reasonably be expected to have a Material Adverse Effect. Neither the Company nor any of its Subsidiaries is aware of any facts or circumstances which might give rise to any of the
foregoing infringements or claims, actions or proceedings, except for such facts and circumstances as would not reasonably be expected to have a Material Adverse Effect. The Company and its Subsidiaries have taken reasonable security measures to
protect the secrecy, confidentiality and value of all of their Intellectual Property Rights. 
 (w) Insurance. The
Company and the Subsidiaries are insured by insurers of recognized financial responsibility against such losses and risks and in such amounts as are prudent and customary in the businesses and location in which the Company and the Subsidiaries are
engaged. 
 (x) Regulatory Permits. The Company and the Subsidiaries possess all certificates, authorizations and
permits issued by the appropriate federal, state, local or foreign regulatory authorities necessary to conduct their respective businesses as presently conducted and described in the SEC Reports (“Material Permits”), except where
the failure to possess such permits does not, individually or in the aggregate, have or reasonably be expected to result in a Material Adverse Effect, and neither the Company nor any Subsidiary has received any written notice of proceedings relating
to the revocation or modification of any Material Permit. 
 (y) Transactions With Affiliates and Employees. Except as
set forth or incorporated by reference in the Company’s SEC Reports, none of the officers, directors or employees of the Company is presently a party to any transaction that would be required to be reported on Form 10-K with the Company or any
of its Subsidiaries (other than for ordinary course services as employees, officers or directors), including any contract, agreement or other arrangement providing for the furnishing of services to or by, providing for rental of real or personal
property to or from, or otherwise requiring payments to or from any such officer, director or employee or, to the Company’s knowledge, any corporation, partnership, trust or other entity in which any such officer, director, or employee has a
substantial interest or is an officer, director, trustee or partner. 
 (z) Internal Accounting Controls. The Company
and the Subsidiaries maintain a system of internal accounting controls sufficient to provide reasonable assurance that (i) transactions are executed in accordance with management’s general or specific authorizations, (ii) transactions
are recorded as necessary to permit preparation of financial statements in conformity with generally accepted accounting principles and to maintain asset accountability, (iii) access to assets is permitted only in accordance with
management’s general or specific authorization, and (iv) the recorded accountability for assets is compared with the existing assets at reasonable intervals and appropriate action is 

  
 16 

 
taken with respect to any differences. During the twelve months prior to the date hereof neither the Company nor any of its Subsidiaries have received any notice or correspondence in writing from
any accountant relating to any potential material weakness in any part of the system of internal accounting controls of the Company or any of its Subsidiaries. 

(aa) Disclosure Controls and Procedures. The Company maintains disclosure controls and procedures (as such term is
defined in Rule 13a-15 of the General Rules and Regulations under the Exchange Act) that comply with the requirements of the Exchange Act; such disclosure controls and procedures have been designed to ensure that information required to be disclosed
by the Company and its Subsidiaries is accumulated and communicated to the Company’s management, including the Company’s principal executive officer and principal financial officer by others within those entities, such disclosure controls
and procedures are effective. 
 (bb) Sarbanes-Oxley Act. The Company is in compliance in all material respects with
any and all applicable requirements of the Sarbanes-Oxley Act of 2002 that are effective as of the date hereof, and any and all applicable rules and regulations promulgated by the SEC thereunder that are effective as of the date hereof. 

(cc) Foreign Corrupt Practices. Neither the Company nor any of its Subsidiaries nor, to the knowledge of the Company,
any director, officer, agent, employee or other Person acting on behalf of the Company or any of its Subsidiaries has, in the course of its actions for, or on behalf of, the Company (i) used any corporate funds for any unlawful contribution,
gift, entertainment or other unlawful expenses relating to political activity; (ii) made any direct or indirect unlawful payment to any foreign or domestic government official or employee from corporate funds; (iii) violated or is in
violation of any provision of the U.S. Foreign Corrupt Practices Act of 1977, as amended; or (iv) made any unlawful bribe, rebate, payoff, influence payment, kickback or other unlawful payment to any foreign or domestic government official or
employee, except where such actions would not have, individually or in aggregate, a Material Adverse Effect. 
 (dd)
Indebtedness. Except as disclosed in Schedule 3.1(dd), neither the Company nor any of its Subsidiaries (i) has any outstanding Indebtedness (as defined below), (ii) is in violation of any term of or in default under any
contract, agreement or instrument relating to any Indebtedness, except where such violations and defaults would not result, individually or in the aggregate, in a Material Adverse Effect, or (iii) is a party to any contract, agreement or
instrument relating to any Indebtedness, the performance of which, in the judgment of the Company’s officers, has or is expected to have a Material Adverse Effect. Schedule 3.1(dd) provides a detailed description of the material terms of
any such outstanding Indebtedness. For purposes of this Agreement: (x) “Indebtedness” of any Person means, without duplication (A) all indebtedness for borrowed money, (B) all obligations issued, undertaken or assumed
as the deferred purchase price of property or services (other than trade payables entered into in the ordinary course of business), (C) all reimbursement or payment obligations with respect to letters of credit, surety bonds and other similar
instruments, (D) all obligations evidenced by notes, bonds, debentures or 

  
 17 

 
similar instruments, including obligations so evidenced incurred in connection with the acquisition of property, assets or businesses, (E) all indebtedness created or arising under any
conditional sale or other title retention agreement, or incurred as financing, in either case with respect to any property or assets acquired with the proceeds of such indebtedness (even though the rights and remedies of the seller or bank under
such agreement in the event of default are limited to repossession or sale of such property), (F) all monetary obligations under any leasing or similar arrangement which, in connection with generally accepted accounting principles, consistently
applied for the periods covered thereby, is classified as a capital lease, (G) all indebtedness referred to in clauses (A) through (F) above secured by (or for which the holder of such Indebtedness has an existing right, contingent or
otherwise, to be secured by) any mortgage, lien, pledge, charge, security interest or other encumbrance upon or in any property or assets (including accounts and contract rights) owned by any Person, even though the Person which owns such assets or
property has not assumed or become liable for the payment of such indebtedness, and (H) all Contingent Obligations in respect of indebtedness or obligations of others of the kinds referred to in clauses (A) through (G) above;
(y) “Contingent Obligation” means, as to any Person, any direct or indirect liability, contingent or otherwise, of that Person with respect to any indebtedness, lease, dividend or other obligation of another Person if the
primary purpose or intent of the Person incurring such liability, or the primary effect thereof, is to provide assurance to the obligee of such liability that such liability will be paid or discharged, or that any agreements relating thereto will be
complied with, or that the holders of such liability will be protected (in whole or in part) against loss with respect thereto; and (z) “Person” means an individual, a limited liability company, a partnership, a joint venture,
a corporation, a trust, an unincorporated organization and a government or any department or agency thereof. 
 (ee)
Employee Relations. Neither the Company nor any of its Subsidiaries is a party to any collective bargaining agreement or, to the Company’s knowledge, employs any member of a union. The Company believes that its relations with its
employees are as disclosed in the SEC Reports. Except as disclosed in the SEC Reports, during the twenty-four month period covered by the SEC Reports, no executive officer of the Company or any of its Subsidiaries (as defined in Rule 501(f) of the
Securities Act) has notified the Company or any such Subsidiary that such officer intends to leave the Company or any such Subsidiary or otherwise terminate such officer’s employment with the Company or any such Subsidiary. To the knowledge of
the Company or any such Subsidiary, no executive officer of the Company is in violation of any material term of any employment contract, confidentiality, disclosure or proprietary information agreement, non-competition agreement, or any other
contract or agreement or any restrictive covenant, and the continued employment of each such executive officer does not subject the Company to any liability with respect to any of the foregoing matters. 

(ff) Labor Matters. The Company and its Subsidiaries are in compliance in all material respects with all federal, state,
local and foreign laws and regulations respecting labor, employment and employment practices and benefits, terms and conditions of employment and wages and hours, except where failure to be in compliance would not, either individually or in the
aggregate, reasonably be expected to result in a Material Adverse Effect. 

  
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 (gg) Environmental Laws. The Company and its Subsidiaries (i) are in
compliance in all material respects with any and all Environmental Laws (as hereinafter defined), (ii) have received all permits, licenses or other approvals required of them under applicable Environmental Laws to conduct their respective
businesses and (iii) are in compliance in all material respects with all terms and conditions of any such permit, license or approval where, in each of the foregoing clauses (i), (ii) and (iii), the failure to so comply would be reasonably
expected to have, individually or in the aggregate, a Material Adverse Effect. The term “Environmental Laws” means all federal, state, local or foreign laws relating to pollution or protection of human health or the environment (including,
without limitation, ambient air, surface water, groundwater, land surface or subsurface strata), including, without limitation, laws relating to emissions, discharges, releases or threatened releases of chemicals, pollutants, contaminants, or toxic
or hazardous substances or wastes (collectively, “Hazardous Materials”) into the environment, or otherwise relating to the manufacture, processing, distribution, use, treatment, storage, disposal, transport or handling of Hazardous
Materials, as well as all authorizations, codes, decrees, demands or demand letters, injunctions, judgments, licenses, notices or notice letters, orders, permits, plans or regulations issued, entered, promulgated or approved thereunder. 

(hh) Tax Status. Except as disclosed in Schedule 3.1(hh), Company and each of its Subsidiaries (i) has made
or filed all foreign, federal and state income and all other tax returns, reports and declarations required by any jurisdiction to which it is subject, (ii) has paid all taxes and other governmental assessments and charges that are material in
amount, shown or determined to be due on such returns, reports and declarations, except those being contested in good faith and (iii) has set aside on its books provision reasonably adequate for the payment of all taxes for periods subsequent
to the periods to which such returns, reports or declarations apply. There are no unpaid taxes in any material amount claimed to be due by the taxing authority of any jurisdiction, and the officers of the Company know of no basis for any such claim.

 (ii) Shell Company Status. Except as disclosed in Schedule 3.1(ii), the Company is not, and has never been,
an issuer identified in Rule 144(i)(1). 
 (jj) Manipulation of Price. The Company has not, and to its knowledge no
one acting on its behalf has, (i) taken, directly or indirectly, any action designed to cause or to result, or that could reasonably be expected to cause or result, in the stabilization or manipulation of the price of any security of the
Company to facilitate the sale or resale of any of the Securities, (ii) other than the Agents, sold, bid for, purchased, or paid any compensation for soliciting purchases of, any of the Securities, or (iii) other than the Agents, paid or
agreed to pay to any person any compensation for soliciting another to purchase any other securities of the Company. 

  
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 3.2 Representations, Warranties and Covenants of the Investors. Each Investor hereby, as
to itself only and for no other Investor, represents, warrants and covenants to the Company and the Agents as follows: 
 (a)
Organization; Authority. Such Investor is an entity duly organized, validly existing and in good standing under the laws of the jurisdiction of its organization with the requisite corporate, partnership or other power and authority to enter
into and to consummate the transactions contemplated by the Transaction Documents and otherwise to carry out its obligations hereunder and thereunder. The purchase by such Investor of the Securities hereunder has been duly authorized by all
necessary corporate, partnership or other action on the part of such Investor. This Agreement has been duly executed and delivered by such Investor and constitutes the valid and binding obligation of such Investor, enforceable against it in
accordance with its terms, except as may be limited by the Enforceability Exceptions. 
 (b) No Public Sale or
Distribution. Such Investor is (i) acquiring the Common Shares, the Preferred Shares and the Warrants and (ii) upon the Underlying Preferred Shares conversion of such shares Preferred Shares and the Warrant Shares upon exercise of the
Warrants in the ordinary course of business for its own account and not with a view towards, or for resale in connection with, the public sale or distribution thereof, except pursuant to sales registered under the Securities Act or under an
exemption from such registration and in compliance with applicable federal and state securities laws, and such Investor does not have a present arrangement to effect any distribution of the Securities to or through any person or entity; provided,
however, that by making the representations herein, such Investor does not agree to hold any of the Securities for any minimum or other specific term and reserves the right to dispose of the Securities at any time in accordance with or pursuant to a
registration statement or an exemption under the Securities Act and pursuant to the applicable terms of the Transaction Documents). 

(c) Investor Status. Except as previously disclosed to the Company in writing, at the time such Investor was offered the
Securities, it was, and at the date hereof it is, an “accredited investor” as defined in Rule 501(a) under the Securities Act. Such Investor is not a registered broker dealer registered under Section 15(a) of the Exchange Act, or a
member of the Financial Industry Regulatory Authority, Inc. or an entity engaged in the business of being a broker dealer. Except as otherwise disclosed in writing to the Company on Exhibit C-2 (attached hereto) on or prior to the date of this
Agreement, such Investor is not affiliated with any broker dealer registered under Section 15(a) of the Exchange Act, or a member of the Financial Industry Regulatory Authority, Inc. or an entity engaged in the business of being a broker
dealer. 
 (d) Experience of Such Investor. Such Investor, either alone or together with its representatives has such
knowledge, sophistication and experience in business and financial matters so as to be capable of evaluating the merits and risks of the prospective investment in the Securities, and has so evaluated the merits and risks of such investment. Such
Investor understands that it must bear the economic risk of this investment in the Securities indefinitely, and is able to bear such risk and is able to afford a complete loss of such investment. 

  
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 (e) Access to Information. Such Investor acknowledges that it has reviewed
the Disclosure Materials and has been afforded: (i) the opportunity to ask such questions as it has deemed necessary of, and to receive answers from, the Company and its representatives concerning the terms and conditions of the offering of the
Securities and the merits and risks of investing in the Securities; (ii) access to information (other than material non-public information) about the Company and the Subsidiaries and their respective financial condition, results of operations,
business, properties, management and prospects sufficient to enable it to evaluate its investment; and (iii) the opportunity to obtain such additional information that the Company possesses or can acquire without unreasonable effort or expense
that is necessary to make an informed investment decision with respect to the investment. Neither such inquiries nor any other investigation conducted by or on behalf of such Investor or its representatives or counsel shall modify, amend or affect
such Investor’s right to rely on the truth, accuracy and completeness of the Disclosure Materials and the Company’s representations and warranties contained in the Transaction Documents. Such Investor acknowledges that either it has access
to the SEC Reports or has received copies of the SEC Reports. 
 (f) General Solicitation. Such Investor is not
purchasing the Securities as a result of any advertisement, article, notice or other communication regarding the Securities published in any newspaper, magazine or similar media, broadcast over television or radio, disseminated over the Internet or
presented at any seminar or, to its knowledge, any other general solicitation or general advertisement. 
 (g) No
Governmental Review. Such Investor understands that no United States federal or state agency or any other government or governmental agency has passed on or made any recommendation or endorsement of the Securities or the fairness or suitability
of the investment in the Securities nor have such authorities passed upon or endorsed the merits of the offering of the Securities. 

(h) No Conflicts. The execution, delivery and performance by such Investor of this Agreement and the consummation by
such Investor of the transactions contemplated hereby will not (i) result in a violation of the organizational documents of such Investor or (ii) conflict with, or constitute a default (or an event which with notice or lapse of time or
both would become a default) under, or give to others any rights of termination, amendment, acceleration or cancellation of, any agreement, indenture or instrument to which such Investor is a party, or (iii) result in a violation of any law,
rule, regulation, order, judgment or decree (including federal and state securities laws) applicable to such Investor, except in the case of clauses (ii) and (iii) above, for such that are not material and do not otherwise affect the
ability of such Investor to consummate the transactions contemplated hereby. 
 (i) Prohibited Transactions. No
Investor, directly or indirectly, and no Person acting on behalf of or pursuant to any understanding with any Investor, has engaged 

  
 21 

 
in any purchases or sales of any securities, including any derivatives, of the Company (including, without limitation, any Short Sales involving any of the Company’s securities) (a
“Transaction”) since the time that such Investor was first contacted by the Company, the Agents or any other Person regarding an investment in the Company. Such Investor covenants that neither it nor any Person acting on its behalf
or pursuant to any understanding with such Investor will engage, directly or indirectly, in any Transactions prior to the time the transactions contemplated by this Agreement are publicly disclosed. “Short Sales” include, without
limitation, all “short sales” as defined in Rule 200 promulgated under Regulation SHO under the Exchange Act and all types of direct and indirect stock pledges, forward sale contracts, options, puts, calls, short sales, swaps, derivatives
and similar arrangements (including on a total return basis), and sales and other transactions through non-U.S. broker-dealers or foreign regulated brokers. Notwithstanding the foregoing, for avoidance of doubt, nothing contained in this
Section 3.2(i) shall constitute a representation or warranty, or preclude any actions, with respect to the identification of the availability of, or securing of, available shares to borrow in order to effect Short Sales or similar transactions
once the transactions contemplated by this Agreement have been publicly announced. 
 (j) Restricted Securities. The
Investors understand that the Securities are characterized as “restricted securities” under the U.S. federal securities laws inasmuch as they are being acquired from the Company in a transaction not involving a public offering and that
under such laws and applicable regulations such securities may be resold without registration under the Securities Act only in certain limited circumstances. 

(k) Legends. It is understood that, except as provided in Section 4.1(b) of this Agreement, certificates evidencing
such Securities shall bear the legend set forth in Section 4.1(b). 
 (l) No Legal, Tax or Investment Advice.
Such Investor understands that nothing in this Agreement or any other materials presented by or on behalf of the Company to the Investor in connection with the purchase of the Securities constitutes legal, tax or investment advice. Such Investor has
consulted such legal, tax and investment advisors as it, in its sole discretion, has deemed necessary or appropriate in connection with its purchase of the Securities. Such Investor understands that the Agents has acted solely as the agent of the
Company in this placement of the Securities and not to the Investor, and that the Agents make no representation or warranty with regard to the merits of this transaction or as to the accuracy of any information such Investor may have received in
connection therewith. Such Investor acknowledges that he has not relied on any information or advice furnished by or on behalf of the Agents. 

(m) Brokers or Finders. Such Investor has not engaged any brokers, finders or agents, and neither the Company nor any
Investor has, nor will, incur, directly or indirectly, as a result of any action by each Investor, any liability for brokerage or finders’ fees or agents’ commissions or any similar charges in connection with the Transaction Documents.

  
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 ARTICLE IV 

OTHER AGREEMENTS OF THE PARTIES 

4.1 Transfer Restrictions. 

(a) The Investors covenant that the Securities will only be disposed of pursuant to an effective registration statement under,
and in compliance with the requirements of, the Securities Act or pursuant to an available exemption from the registration requirements of the Securities Act, and in compliance with any applicable state securities laws. In connection with any
transfer of Securities other than pursuant to an effective registration statement or Rule 144, the Company may require the transferor to provide to the Company an opinion of counsel selected by the transferor, the form and substance of which opinion
shall be reasonably satisfactory to the Company, to the effect that such transfer does not require registration under the Securities Act. Notwithstanding the foregoing, the Company hereby consents to and agrees to register on the books of the
Company and with its Transfer Agent, without any such legal opinion, any transfer of Securities by an Investor to an Affiliate of such Investor, provided that the transferee certifies to the Company that it is an “accredited investor” as
defined in Rule 501(a) under the Securities Act and provided that such Affiliate does not request any removal of any existing legends on any certificate evidencing the Securities. The Company shall cause its counsel to provide any legal opinions
required by its transfer agent. 
 (b) The Investors agree to the imprinting, until no longer required by this
Section 4.1(b), of the following legend on any certificate evidencing any of the Securities: 
 THESE SECURITIES HAVE NOT BEEN
REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR ANY APPLICABLE
STATE SECURITIES LAWS AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION
REQUIREMENTS OF THE SECURITIES ACT AND IN COMPLIANCE WITH APPLICABLE STATE SECURITIES LAWS OR BLUE SKY LAWS. 
 The legend set forth above
shall be removed and the Company shall issue a certificate without such legend to the holder of the Securities upon which it is stamped or issue to such holder by electronic delivery at the applicable balance account of The Depository Trust Company
(“DTC”), if, unless otherwise required by state securities laws, (i) such Securities are registered for resale under the Securities Act and are transferred to the Investor pursuant to a registration statement that is effective
at the time of such transfer, (ii) in connection with a sale, assignment or other transfer, such holder provides the Company with an opinion of counsel, the form and substance of which opinion shall be reasonably acceptable to the Company, that
the sale, assignment or transfer of the Securities may be made without registration under the applicable requirements of the Securities Act or (iii)

  
 23 

 
such holder provides the Company with reasonable assurance that the Securities can be sold, assigned or transferred pursuant to Rule 144 or have been sold under Rule 144. If the Company shall
fail for any reason or for no reason to issue to the holder of the Securities within three (3) Trading Days after the holder has provided reasonable evidence to the Company of the occurrence of any of (i) through (iii) above (the date
such evidence is provided to the Company, the “Removal Date”), a certificate without such legend to the holder or to issue such Securities to such holder by electronic delivery at the applicable balance account at DTC (as defined
below), and if on or after such Trading Day the holder purchases (in an open market transaction or otherwise) the Common Stock issued to the Investors pursuant to this Agreement to deliver in satisfaction of a sale by the holder of such Securities
that the holder anticipated receiving without legend from the Company (a “Buy-In”), then the Company shall, within three (3) Business Days after the holder’s request and in the holder’s discretion, either (i) pay
cash to the holder in an amount equal to the holder’s total purchase price (including brokerage commissions, if any) for the Common Stock issued to Investors so purchased (the “Buy-In Price”), at which point the Company’s
obligation to deliver such unlegended Securities shall terminate, or (ii) promptly honor its obligation to deliver to the holder such unlegended Securities as provided above and pay cash to the holder in an amount equal to the excess (if any)
of the Buy-In Price over the product of (A) such number of shares of Common Stock, times (B) the Closing Price on the Removal Date. 

(c) The Company will not object to and shall permit (except as prohibited by law) an Investor to pledge or grant (“Pledge”) a
security interest in some or all of the Securities in connection with a bona fide margin agreement or other loan or financing arrangement secured by the Securities, and if required under the terms of such agreement, loan or arrangement, the Company
will not object to and shall permit (except as prohibited by law) such Investor to transfer pledged or secured Securities to the pledges or secured parties; provided, that following such Pledge, the Securities shall continue to have the restrictive
legends set forth in Section 4.1(b) above unless the legends may be removed pursuant to the provisions of Sections 4.1(b)(i), (ii), or (iii). Except as required by law, such a pledge or transfer would not be subject to approval of the Company,
no legal opinion of the pledgee, secured party or pledgor shall be required in connection therewith, and no notice shall be required of such pledge. Each Investor acknowledges that the Company shall not be responsible for any pledges relating to, or
the grant of any security interest in, any of the Securities or for any agreement, understanding or arrangement between any Investor and its pledgee or secured party. The Company will execute and deliver such reasonable documentation as a pledgee or
secured party of Securities may reasonably request in connection with a pledge or transfer of the Securities, including the preparation and filing of any required prospectus supplement under Rule 424(b)(3) of the Securities Act or other applicable
provision of the Securities Act to appropriately amend the list of Selling Stockholders thereunder. Provided that the Company is in compliance with the terms of this Section 4.1(c), the Company’s indemnification obligations pursuant to
Section 6.4 shall not extend to any Proceeding or Losses arising out of or related to this Section 4.1(c). 
 (d) The restrictions
set forth in this Section 4.1 shall be in addition to the applicable transfer restrictions or other requirements set forth in the Certificate of Designation and the Investors acknowledge and agree to be bound thereby. 

4.2 Furnishing of Information. Until the date that any Investor owning the shares of Common Shares, Preferred Shares, Underlying
Preferred Shares, Warrants or Warrant Shares may 

  
 24 

 
sell all of them without restriction or limitation under Rule 144 of the Securities Act (or any successor provision) (including, without limitation, the requirement to be in compliance with Rule
144(c)(1)), the Company covenants to use its commercially reasonable efforts to timely file (or obtain extensions in respect thereof and file within the applicable grace period) all reports required to be filed by the Company after the date hereof
pursuant to the Exchange Act. 
 4.3 Integration. The Company shall not, and shall use its commercially reasonably efforts to ensure
that no Affiliate thereof shall, sell, offer for sale or solicit offers to buy or otherwise negotiate in respect of any security (as defined in Section 2 of the Securities Act) that would be integrated with the offer or sale of the Securities
in a manner that would require the registration under the Securities Act of the sale of the Securities to the Investors or that would be integrated with the offer or sale of the Securities for purposes of the rules and regulations of any Trading
Market. 
 4.4 Reservation of Securities. The Company shall maintain a reserve from its duly authorized shares of Common Stock for
issuance pursuant to the Transaction Documents in such amount as may be required to fulfill its obligations to issue such shares under the Transaction Documents. In the event that at any time the then authorized shares of Common Stock are
insufficient for the Company to satisfy its obligations to issue such shares of Common Stock under the Transaction Documents, the Company shall use reasonable best efforts to promptly take such actions as may be required to increase the number of
authorized shares. 
 4.5 Securities Laws Disclosure; Publicity. The Company shall, on or before 8:30 a.m., New York time, on the
first Trading Day following execution of this Agreement, issue a press release (the “Press Release”) and file a Current Report on Form 8-K with the SEC (the “8-K Filing”) describing all material terms of the
transactions contemplated by the Transaction Documents and including as exhibits to such Form 8-K Filing the Transaction Documents. Except as herein provided, the Company shall not publicly disclose the name of any Investor, or include the name of
any Investor in any press release without the prior written consent of such Investor, unless otherwise required by law. The Company shall not, and shall cause each of its Subsidiaries and its and each of their respective officers, directors,
employees and agents not to, provide any Investor with any material nonpublic information regarding the Company or any of its Subsidiaries from and after the issuance of the above referenced press release without the express written consent of such
Investor; provided, however, such restriction shall not apply with respect to any material nonpublic information That the Company is required to deliver to an Investor pursuant to the Transaction Documents. 

4.6 Use of Proceeds. The Company intends to use the net proceeds from the sale of the Securities for working capital and general
corporate purposes, including, without limitation, in connection with the Allenex Offer. 
 4.7 Form D and Blue Sky. The Company
agrees to file a Form D with respect to the Securities as required under Regulation D. The Company, on or before the Closing Date, shall take such action as the Company shall reasonably determine is necessary in order to obtain an exemption for or
to qualify the Securities for sale to the Investors at the Closing pursuant to this Agreement under applicable securities or “Blue Sky” laws of the states of the United States (or to obtain an exemption from such qualification), and shall
provide evidence of any such action so taken to the Investors on or prior to the Closing Date. The Company shall make all filings and reports relating to the offer and sale of the Securities required under applicable securities or “Blue
Sky” laws of the states of the United States following the Closing Date. 

  
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 4.8 Registration Consultant. The Company shall engage Proskauer Rose LLP to act as a
registration consultant (the “Registration Consultant”) and shall pay such Registration Consultant reasonable and documented fees and expenses, which amount shall not, without the prior written consent of the Company, exceed $20,000
in the aggregate per Registration Statement for all filings (including, but not limited to, amendments and supplements thereto) relating to, and the registration and qualification of the securities underlying, such Registration Statement. The
Company shall (A) permit the Registration Consultant to review and comment upon (i) a Registration Statement at least ten (10) Business Days prior to its filing with the SEC and (ii) all amendments and supplements to all
Registration Statements within a reasonable number of days prior to their filing with the SEC, (B) permit each Investor to review and comment on the “Plan of Distribution” and “Selling Stockholders” sections of the
Registration Statement and all amendments and supplements to the Registration Statement to the extent any changes are made to those sections, and (C) not file any Registration Statement or amendment or supplement thereto in a form to which the
Registration Consultant reasonably objects. The Company shall not submit a request for acceleration of the effectiveness of a Registration Statement or any amendment or supplement thereto without the prior approval of the Registration Consultant,
which consent shall not be unreasonably withheld. The Company shall promptly furnish to the Registration Consultant copies of any correspondence from the SEC or the staff of the SEC to the Company or its representatives relating to any
Registration Statement. The Company shall cause the Registration Consultant to be included on all substantive communications with the SEC and the Company’s legal counsel with respect to, and to receive all drafts of, the Registration
Statement and any amendments and supplements thereto. 
 4.9 Stockholder Meeting. The Company shall provide each stockholder
entitled to vote at a special or annual meeting of stockholders of the Company (the “Stockholder Meeting”), which initially shall be promptly called and held not later than June 30, 2016 (the “Stockholder Meeting
Deadline”), a proxy statement substantially in the form which has been previously reviewed by the Investors and a counsel of their choice, at the expense of the Company, soliciting each such stockholder’s affirmative vote at the
Stockholder Meeting for Stockholder Approval of resolutions (“Stockholder Resolutions”) providing for the Company’s issuance of all of the Securities as described in the Agreement in accordance with applicable law and results
and regulations of The NASDAQ Stock Market, including the issuance of the Underlying Preferred Share upon conversion of the Preferred Shares, the issuance of the Warrant Shares upon exercise of the Warrants and the exercise price adjustment
provisions of the Warrants (the date such approval is obtained, the “Stockholder Approval Date”, and the Company shall use its reasonable best efforts to solicit its stockholders’ approval of Stockholder Resolutions and to
cause the Board to recommend to the stockholders that they approve the Stockholder Resolutions. The Company shall be obligated to seek to obtain the Stockholder Approval by the Stockholder Meeting Deadline. 

4.10 Exercise of Commitment. Following the Closing, and in no event later than 30 days following the Stockholder Approval Date, the
Company shall exercise its rights under the Commitment Letters and issue and sell securities on terms, including price, substantially equivalent to the terms of the Securities sold pursuant to this Agreement for an aggregate amount of at least
$8,000,000. 

  
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 ARTICLE V 

CONDITIONS 
 5.1 Conditions
Precedent to the Obligations of the Investors. The obligation of each Investor to acquire Securities at the Closing is subject to the satisfaction or waiver by such Investor, at or before the Closing, of each of the following conditions: 

(a) Representations and Warranties. The representations and warranties of the Company contained herein shall be true and
correct in all material respects (except for those representations and warranties which are qualified by materiality or Material Adverse Effect, which shall be true and correct in all respects) as of the date when made and as of the Closing as
though made on and as of such date (except for representations and warranties that speak as of a specific date, which shall be true and correct as of such specified date); 

(b) Performance. The Company and each other Investor shall have performed, satisfied and complied in all material
respects with all covenants, agreements and conditions required by the Transaction Documents to be performed, satisfied or complied with by it at or prior to the Closing, including: 

(i) The Company shall have filed the Certificate of Designation with the Secretary of State of the State of Delaware; and 

(ii) The Company shall have issued the shares of Common Shares, the Preferred Shares and the Warrants to the Investors; 

(c) Voting Agreement. The Investors and such other stockholders of the Company holding in the aggregate a majority of
the Company’s voting capital stock entitled to vote at the Stockholder Meeting in accordance with the requirements of The NASDAQ Global Market (the “Voting Stockholders”) shall have each entered into a voting agreement with the
Company in the form attached hereto as Exhibit H (the “Voting Agreement”) pursuant to which the Investors and such stockholders shall agree to vote at the Stockholder Meeting all shares of the Company’s capital stock
held by such Investors or stockholders to approve the transactions contemplated by this Agreement including the conversion of the Preferred Shares into the Underlying Preferred Shares, the issuance of the Warrant Shares upon exercise of the Warrants
and the adjustment provisions of the Warrants in accordance with Section 4.9 of this Agreement; 
 (d) Minimum
Condition. The Company shall have consummated an offering pursuant to which the Company shall have raised in the aggregate at least $12,000,000 of gross proceeds from the sale of the Units pursuant to this Agreement and shall have received,
directly or in escrow, at least $8,000,000 in funds from the Commitment Stockholders under the Commitment Letter. 
 (e)
Closing of Allenex Offer. The closing and settlement of the Allenex Offer shall have occurred; and 

  
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 (f) East West Facility Condition. The consent of East West Bank under the
Loan and Security Agreement, dated as of January 30, 2015, by and between East West Bank and the Company, necessary to be obtained by the Company in connection with the consummation of the Allenex Offer and the transactions contemplated thereby
and related thereto shall have been obtained and shall remain in effect. 
 5.2 Conditions Precedent to the Obligations of the
Company. The obligation of the Company to sell the Securities at the Closing is subject to the satisfaction or waiver by the Company, at or before the Closing, of each of the following conditions: 

(a) Representations and Warranties. The representations and warranties of the Investors contained herein shall be true
and correct in all material respects (except for those representations and warranties which are qualified by materiality or Material Adverse Effect, which shall be true and correct in all respects) as of the date when made and as of the Closing Date
as though made on and as of such date (except for representations and warranties that speak as of a specific date, which shall be true and correct as of such specified date); 

(b) Performance. The Investors shall have performed, satisfied and complied in all material respects with all covenants,
agreements and conditions required by the Transaction Documents to be performed, satisfied or complied with by the Investors at or prior to the Closing, including: 

(iii) The Company shall have received completed forms of Exhibit C-1, C-2, C-3 and C-4 from each Investor; 

(iv) The purchase of and payment for the shares of Common Shares, the Preferred Shares and the Warrants by each Investor shall not be
prohibited or enjoined by any law or governmental or court order or regulation; and 
 (v) The Company shall have filed the Certificate of
Designation with the Secretary of the State of Delaware. 
 (c) Voting Agreement. The Investors and Voting
Stockholders shall have each entered into the Voting Agreement; and 
 (d) Minimum Condition. The Company shall have
consummated an offering pursuant to which the Company shall have raised in the aggregate at least $12,000,000 of gross proceeds from the sale of the Units pursuant to this Agreement and shall have received, directly or in escrow, at least $8,000,000
in funds from the Commitment Stockholders under the Commitment Letter. 
 (e) East West Facility Condition. The
consent of East West Bank under the Loan and Security Agreement, dated as of January 30, 2015, by and between East West Bank and the Company, necessary to be obtained by the Company in connection with the consummation of the Allenex Offer and
the transactions contemplated thereby and related transactions shall have been obtained and shall remain in effect. 

  
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 ARTICLE VI 

REGISTRATION RIGHTS 
 6.1
Registration Statement. 
 (a) As promptly as possible, and in any event on or prior to the Initial Filing Date, the
Company shall prepare and file with the SEC a Registration Statement covering the resale of all Registrable Securities for an offering to be made on a continuous basis pursuant to Rule 415. The Registration Statement shall be on Form S-3 (except if
the Company is not then eligible to register for resale the Registrable Securities on Form S-3, in which case such registration shall be on another appropriate form in accordance with the Securities Act and the Exchange Act) and shall contain
(except if otherwise directed by the Investors or requested by the SEC) the “Plan of Distribution” in substantially the form attached hereto as Exhibit E and the “Selling Stockholders” in substantially the form attached
hereto as Exhibit F. To the extent the staff of the SEC does not permit all of the Registrable Securities to be registered on the initial Registration Statement filed pursuant to this Section 6.1(a) (the “Initial Registration
Statement”), the Company shall file additional Registration Statements (each an “Additional Registration Statement”), as promptly as possible, and in any event on or prior to the Additional Filing Date, successively trying
to register on each such Additional Registration Statement the maximum number of remaining Registrable Securities until all of the Registrable Securities have been registered with the SEC. 

(b) The Company shall use its commercially reasonable efforts to cause each Registration Statement to be declared effective by
the SEC as promptly as possible after the filing thereof, but in any event prior to the applicable Required Effectiveness Date, and shall use its commercially reasonable efforts to keep the Registration Statement continuously effective under the
Securities Act until the earlier of the date that all Registrable Securities covered by such Registration Statement have been sold or can be sold publicly without restriction or limitation under Rule 144 (including, without limitation, the
requirement to be in compliance with Rule 144(c)(1)) (the “Effectiveness Period”); provided that, upon notification by the SEC that a Registration Statement will not be reviewed or is no longer subject to further review and
comments, the Company shall request acceleration of such Registration Statement within three (3) Trading Days after receipt of such notice and request that it becomes effective on 4:00 p.m. New York City time on the Effective Dave and file a
prospectus supplement for any Registration Statement, whether or not required under Rule 424 (or otherwise), by 9:00 a.m. New York City time the day after the Effective Date. 

(c) The Company shall notify the Investors in writing promptly (and in any event within two Trading Days) after receiving
notification from the SEC that a Registration Statement has been declared effective. 
 (d) Should an Event (as defined
below) occur, then upon the occurrence of such Event, and on every monthly anniversary thereof until the applicable Event is cured, the Company shall pay to each Investor an amount in cash, as liquidated damages and not

  
 29 

 
as a penalty, equal to two percent (2.0%) of the aggregate Purchase Price of the Registrable Securities then held by the Investor; provided, however, that the total amount of payments
pursuant to this Section 6.1(d) shall not exceed, when aggregated with all such payments paid to all Investors, ten percent (10%) of the aggregate Purchase Price hereunder; provided, further, that Events occurring pursuant to
clause (iv) of such definition shall not count toward, or be subject to such ten percent (10%) cap. The payments to which an Investor shall be entitled pursuant to this Section 6.1(d) are referred to herein as “Event
Payments.” Any Event Payments payable pursuant to the terms hereof shall apply on a pro-rated basis for any portion of a month prior to the cure of an Event. In the event the Company fails to make Event Payments in a timely manner, such
Event Payments shall bear interest at the rate of one and a half percent (1.5%) per month (prorated for partial months) until paid in full. All pro-rated calculations made pursuant to this paragraph shall be based upon the actual number of days
in such pro-rated month. 
 For such purposes, each of the following shall constitute an “Event”: 

(i) a Registration Statement is not filed on or prior to its Filing Date or is not declared effective on or prior to its Required
Effectiveness Date or does not register all Registrable Securities; provided that if the SEC, by written or oral comment or otherwise, limits the Company’s ability to request effectiveness, or prohibits the effectiveness of, a Registration
Statement with respect to any or all the Registrable Securities pursuant to Rule 415, it shall not be a breach or default by the Company under this Agreement and shall not be deemed a failure by the Company to use reasonable best efforts; 

(ii) except as provided for in Section 6.1(e) (the “Excluded Events”), after the Effective Date of a
Registration Statement, an Investor is not permitted to sell Registrable Securities under the Registration Statement (or a subsequent Registration Statement filed in replacement thereof) for any reason (other than the fault of such Investor) for
five (5) or more Trading Days (whether or not consecutive); 
 (iii) except as a result of the Excluded Events, the Common Stock is
not listed or quoted, or is suspended from trading, on an Eligible Market for a period of three Trading Days (which need not be consecutive Trading Days) during the Effectiveness Period; and 

(iv) at any time during the period commencing from the six (6) month anniversary of the Closing Date and ending at the termination of
the Effectiveness Period, if a Registration Statement is not available for the resale of all of the Registrable Securities and the Company shall fail for any reason to satisfy the current public information requirement under Rule 144(c); 

provided, that Event Payments on the Registrable Securities may not accrue under more than one of the foregoing clauses (i), (ii), (iii) and (iv),
at any one time; and provided further, that (1) upon the filing of the Registration Statement as required hereunder (in the case of Section 6.1(i)), (2) upon the effectiveness of a Registration Statement as
required hereunder (in the case of Section 6.1(ii)), (3) upon the resumed trading of the Common Stock (in the case of Section 6.1(iii)), or (4) upon the resumption of an Investors ability to resell the Registrable
Securities under an effective Registration 

  
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Statement or the Company’s satisfaction of the current public information requirement under Rule 144(c) of the Securities Act (in the case of Section 6.1(d)), Event Payments on
the Registrable Securities as a result of such clause shall cease to accrue. It is understood and agreed that, notwithstanding any provision to the contrary, no Event Payments shall accrue on any Registrable Securities that are then covered by, and
may be sold under, an Effective Registration Statement. 
 (e) Notwithstanding anything in this Agreement to the contrary: 

(i) notwithstanding Section 6.1, the Company, upon written notice to the Investors, shall be permitted to suspend the
availability of a Registration Statement covering the Registrable Securities for any bona fide reason whatsoever for up to 15 consecutive days (the “Deferral Period”) in any 90-day period without being obligated to pay liquidated
damages; provided, that Deferral Periods may not total more than 45 days in the aggregate in any twelve-month period. The Company shall not be required to specify in the written notice to the Investors the nature of the event giving rise to
the Deferral Period; and 
 (ii) the Company may, by written notice to the Investors, suspend sales under a Registration Statement after
the Effective Date thereof and/or require that the Investors immediately cease the sale of shares of Common Stock pursuant thereto and/or defer the filing of any subsequent Registration Statement if the Company is engaged in a material merger,
acquisition or sale and the Board of Directors determines in good faith, by appropriate resolutions, that, as a result of such activity, (A) it would be materially detrimental to the Company (other than as relating solely to the price of the
Common Stock) to maintain a Registration Statement at such time or (B) it is in the best interests of the Company to suspend sales under such registration at such time. Upon receipt of such notice, each Investor shall immediately discontinue
any sales of Registrable Securities pursuant to such registration until such Investor is advised in writing by the Company that the current Prospectus or amended Prospectus, as applicable, may be used. 

In no event, however, shall this right be exercised to suspend sales beyond the period during which (in the good faith determination of the Company’s
Board of Directors) the failure to require such suspension would be materially detrimental to the Company. The Company’s rights under this Section 6(e) may be exercised for a period of no more than 20 calendar days at a time and not
more than three times in any twelve-month period, without such suspension being considered as part of an Event Payment determination. Immediately after the end of any suspension period under this Section 6(e), the Company shall take all
necessary actions (including filing any required supplemental prospectus) to restore the effectiveness of the applicable Registration Statement and the ability of the Investors to publicly resell their Registrable Securities pursuant to such
effective Registration Statement. 
 6.2 Registration Procedures. In connection with the Company’s registration obligations
hereunder, the Company shall: 
 (a) Not less than three Trading Days prior to the filing of a Registration Statement or any
related Prospectus or any amendment or supplement thereto, furnish via email to those Investors who have supplied the Company with email addresses copies of all such documents proposed to be filed (or at the request of one or more Investors, only

  
 31 

 
certain sections thereof), which documents (other than any document that is incorporated or deemed to be incorporated by reference therein) will be subject to the review of such Investors. The
Company shall reflect in each such document when so filed with the SEC such comments regarding the Investors and the plan of distribution as the Investors may reasonably and promptly propose no later than two Trading Days after the Investors have
been so furnished with copies of such documents as aforesaid. 
 (b) (i) Subject to Section 6.1(e), prepare
and file with the SEC such amendments, including post-effective amendments, to each Registration Statement and the Prospectus used in connection therewith as may be necessary to keep the Registration Statement continuously effective, as to the
applicable Registrable Securities for the Effectiveness Period and prepare and file with the SEC such additional Registration Statements in order to register for resale under the Securities Act all of the Registrable Securities; (ii) cause the
related Prospectus to be amended or supplemented by any required Prospectus supplement, and as so supplemented or amended to be filed pursuant to Rule 424; and (iii) comply in all material respects with the provisions of the Securities Act and
the Exchange Act with respect to the disposition of all Registrable Securities covered by the Registration Statement during the applicable period in accordance with the intended methods of disposition by the Investors thereof set forth in the
Registration Statement as so amended or in such Prospectus as so supplemented. 
 (c) Notify the Investors as promptly as
reasonably possible, and if requested by the Investors, confirm such notice in writing no later than two Trading Days thereafter, of any of the following events: (i) the SEC notifies the Company whether there will be a “review” of any
Registration Statement; (ii) any Registration Statement or any post-effective amendment is declared effective; (iii) the SEC issues any stop order suspending the effectiveness of any Registration Statement or initiates any Proceedings for
that purpose; (iv) the Company receives notice of any suspension of the qualification or exemption from qualification of any Registrable Securities for sale in any jurisdiction, or the initiation or threat of any Proceeding for such purpose; or
(v) the financial statements included in any Registration Statement become ineligible for inclusion therein or any Registration Statement or Prospectus or other document contains any untrue statement of a material fact or omits to state any
material fact required to be stated therein or necessary to make the statements therein, in the light of the circumstances under which they were made, not misleading. 

(d) Use its commercially reasonable efforts to avoid the issuance of or, if issued, obtain the withdrawal of (i) any order
suspending the effectiveness of any Registration Statement, or (ii) any suspension of the qualification (or exemption from qualification) of any of the Registrable Securities for sale in any jurisdiction, as soon as possible. 

(e) If requested by an Investor, provide such Investor and Counsel to the lead investor, without charge, at least one conformed
copy of each Registration Statement and each amendment thereto, including financial statements and schedules, and all exhibits to the extent requested by such Person (including those previously furnished or incorporated by reference) promptly after
the filing of such documents with the SEC. 

  
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 (f) Promptly deliver to each Investor, without charge, as many copies of the
Prospectus or Prospectuses (including each form of prospectus) and each amendment or supplement thereto as such Persons may reasonably request. The Company hereby consents to the use of such Prospectus and each amendment or supplement thereto by
each of the selling Investors in connection with the offering and sale of the Registrable Securities covered by such Prospectus and any amendment or supplement thereto to the extent permitted by federal and state securities laws and regulations.

 (g) (i) In the time and manner required by each Trading Market on which the Common Stock is listed, prepare and file
with such Trading Market an additional shares listing application covering all of the Registrable Securities; (ii) take all steps necessary to cause such Registrable Securities to be approved for listing on each such Trading Market as soon as
possible thereafter; (iii) provide to each Investor evidence of such approval; and (iv) except as a result of the Excluded Events, during the Effectiveness Period, maintain the listing of such Registrable Securities on each such Trading
Market or another Eligible Market. 
 (h) Prior to any public offering of Registrable Securities, use its commercially
reasonable efforts to register or qualify or cooperate with the selling Investors in connection with the registration or qualification (or exemption from such registration or qualification) of such Registrable Securities for offer and sale under the
securities or Blue Sky laws of such jurisdictions within the United States as any Investor requests in writing, to keep each such registration or qualification (or exemption therefrom) effective for so long as required, but not to exceed the
duration of the Effectiveness Period, and to do any and all other acts or things reasonably necessary or advisable to enable the disposition in such jurisdictions of the Registrable Securities covered by a Registration Statement; provided,
however, that the Company shall not be obligated to file any general consent to service of process or to qualify as a foreign corporation or as a dealer in securities in any jurisdiction in which it is not so qualified or to subject itself to
taxation in respect of doing business in any jurisdiction in which it is not otherwise so subject. 
 (i) Cooperate with the
Investors to facilitate the timely preparation and delivery of certificates representing Registrable Securities to be delivered to a transferee pursuant to a Registration Statement, which certificates shall be free, to the extent permitted by this
Agreement and under law, of all restrictive legends, and to enable such Registrable Securities to be in such denominations and registered in such names as any such Investors may reasonably request. 

(j) Upon the occurrence of any event described in Sections 6.2(c)(iv), (v) or (vi), as promptly as reasonably
possible, prepare a supplement or amendment, including a post-effective amendment, to the Registration Statement or a supplement to the related Prospectus or any document incorporated or deemed to be incorporated therein by reference, and file any
other required document so that, as thereafter delivered, neither the 

  
 33 

 
Registration Statement nor such Prospectus will contain an untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the statements
therein, in the light of the circumstances under which they were made, not misleading. 
 (k) Cooperate with any reasonable
due diligence investigation undertaken by the Investors in connection with the sale of Registrable Securities, including, without limitation, by making available documents and information; provided that the Company will not deliver or make available
to any Investor material, nonpublic information (other than any material nonpublic information the Company delivers to Investors pursuant to Section 4.9), unless such Investor requests in advance in writing to receive material, nonpublic
information and agrees to keep such information confidential. 
 (l) Comply with all rules and regulations of the SEC
applicable to the registration of the Registrable Securities. 
 (m) It shall be a condition precedent to the obligations of
the Company to complete the registration pursuant to this Agreement with respect to the Registrable Securities of any particular Investor or to make any Event Payments set forth in Section 6.1(c) to such Investor that such Investor furnish to
the Company the information specified in Exhibits C-1, C-2 and C-3 hereto and such other information regarding itself, the Registrable Securities and other shares of Common Stock held by it and the intended method of disposition
of the Registrable Securities held by it (if different from the Plan of Distribution set forth on Exhibit E hereto) as shall be reasonably required to effect the registration of such Registrable Securities and shall complete and execute such
documents in connection with such registration as the Company may reasonably request. 
 (n) The Company shall comply with
all applicable rules and regulations of the SEC under the Securities Act and the Exchange Act, including, without limitation, Rule 172 under the Securities Act, file any final Prospectus, including any supplement or amendment thereof, with the SEC
pursuant to Rule 424 under the Securities Act, promptly inform the Investors in writing if, at any time during the Effectiveness Period, the Company does not satisfy the conditions specified in Rule 172 and, as a result thereof, the Investors are
required to make available a Prospectus in connection with any disposition of Registrable Securities and take such other actions as may be reasonably necessary to facilitate the registration of the Registrable Securities hereunder. 

(o) Not identify any Investor as an underwriter without its prior written consent in any public disclosure or filing with the
SEC, the Trading Market or any Eligible Market and any Investor being deemed an underwriter by the SEC shall not relieve the Company of any obligations it has under this Agreement; provided, however, that the foregoing shall not
prohibit the Company from including the disclosure found in the “Plan of Distribution” section attached hereto as Exhibit E in the Registration Statement. In addition, and notwithstanding anything to the contrary contained herein,
if the Company has received a comment by the SEC requiring an Investor to be named as an underwriter in the Registration Statement (which notwithstanding the reasonable best efforts of the 

  
 34 

 
Company is not withdrawn by the SEC) and such Investor elects in writing not to be named as a selling stockholder in the Registration Statement, the Investor shall not be entitled to any Event
Payments with respect to such Registration Statement. 
 6.3 Registration Expenses. The Company shall pay all fees and expenses
incident to the performance of or compliance with Article VI of this Agreement by the Company, including without limitation (a) all registration and filing fees and expenses, including without limitation those related to filings with the
SEC, any Trading Market, any required filing with the Financial Industry Regulatory Authority by the Agents (but not any Investor), and in connection with applicable state securities or Blue Sky laws, (b) printing expenses (including without
limitation expenses of printing certificates for Registrable Securities), (c) messenger, telephone and delivery expenses, (d) fees and disbursements of counsel for the Company, (e) fees and expenses of all other Persons retained by
the Company in connection with the consummation of the transactions contemplated by this Agreement, and (f) all listing fees to be paid by the Company to the Trading Market. 

6.4 Indemnification 

(a) Indemnification by the Company. The Company shall, notwithstanding any termination of this Agreement, indemnify and
hold harmless each Investor, the officers, directors, partners, members, agents and employees of each of them, each Person who controls any such Investor (within the meaning of Section 15 of the Securities Act or Section 20 of the Exchange
Act) and the officers, directors, partners, members, agents and employees of each such controlling Person, to the fullest extent permitted by applicable law, from and against any and all Losses, as incurred, arising out of or relating to
(i) any misrepresentation or breach of any representation or warranty made by the Company in the Transaction Documents or any other certificate, instrument or document contemplated hereby or thereby, (ii) any breach of any covenant,
agreement or obligation of the Company contained in the Transaction Documents or any other certificate, instrument or document contemplated hereby or thereby, (iii) any cause of action, suit or claim brought or made against such Indemnified
Party (as defined in Section 6.4(c) below) by a third party (including for these purposes a derivative action brought on behalf of the Company), arising out of or resulting from (x) execution, delivery, performance or enforcement of the
Transaction Documents or any other certificate, instrument or document contemplated hereby or thereby, (y) any transaction financed or to be financed in whole or in part, directly or indirectly, with the proceeds of the issuance of the
Securities, or (z) the status of Indemnified Party as holder of the Securities or (iv) any untrue or alleged untrue statement of a material fact contained in the Registration Statement, any Prospectus or any form of Company prospectus or
in any amendment or supplement thereto or in any Company preliminary prospectus, or arising out of or relating to any omission or alleged omission of a material fact required to be stated therein or necessary to make the statements therein (in the
case of any Prospectus or form of prospectus or supplement thereto, in the light of the circumstances under which they were made) not misleading, except to the extent, but only to the extent, that (A) such untrue statements, alleged untrue
statements, omissions or alleged omissions are based solely upon information regarding such Investor furnished in writing to the Company by such Investor for use therein, or to the extent that such information relates to such Investor or such
Investor’s proposed method of distribution of Registrable Securities and was reviewed and expressly approved by such Investor expressly for use in the 

  
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Registration Statement, or (B) with respect to any prospectus, if the untrue statement or omission of material fact contained in such prospectus was corrected on a timely basis in the
prospectus, as then amended or supplemented, if such corrected prospectus was timely made available by the Company to the Holder, and the Holder seeking indemnity hereunder was advised in writing not to use the incorrect prospectus prior to the use
giving rise to Losses. 
 (b) Indemnification by Investors. Each Investor shall, severally and not jointly, indemnify
and hold harmless the Company, its directors, officers, agents and employees, each Person who controls the Company (within the meaning of Section 15 of the Securities Act and Section 20 of the Exchange Act), and the directors, officers,
agents or employees of such controlling Persons, to the fullest extent permitted by applicable law, from and against all Losses (as determined by a court of competent jurisdiction in a final judgment not subject to appeal or review) arising solely
out of any untrue statement of a material fact contained in the Registration Statement, any Prospectus, or any form of prospectus, or in any amendment or supplement thereto, or arising out of or relating to any omission of a material fact required
to be stated therein or necessary to make the statements therein (in the case of any Prospectus or form of prospectus or supplement thereto, in the light of the circumstances under which they were made) not misleading, but only to the extent that
such untrue statement or omission is contained in any information so furnished by such Investor in writing to the Company specifically for inclusion in such Registration Statement or such Prospectus or to the extent that (i) such untrue
statements or omissions are based solely upon information regarding such Investor furnished to the Company by such Investor in writing expressly for use therein, or to the extent that such information relates to such Investor or such Investor’s
proposed method of distribution of Registrable Securities and was reviewed and expressly approved by such Investor expressly for use in the Registration Statement (it being understood that the information provided by the Investor to the Company in
Exhibits C-1, C-2 and C-3 and the Plan of Distribution set forth on Exhibit E, as the same may be modified by such Investor and other information provided by the Investor to the Company in or pursuant to the Transaction
Documents constitutes information reviewed and expressly approved by such Investor in writing expressly for use in the Registration Statement), such Prospectus or such form of Prospectus or in any amendment or supplement thereto. In no event shall
the liability of any selling Investor hereunder be greater in amount than the dollar amount of the net proceeds received by such Investor upon the sale of the Registrable Securities giving rise to such indemnification obligation. 

(c) Conduct of Indemnification Proceedings. If any Proceeding shall be brought or asserted against any Person entitled
to indemnity hereunder (an “Indemnified Party”), such Indemnified Party shall promptly notify the Person from whom indemnity is sought (the “Indemnifying Party”) in writing, and the Indemnifying Party shall assume
the defense thereof, including the employment of counsel reasonably satisfactory to the Indemnified Party and the payment of all fees and expenses incurred in connection with defense thereof; provided, that the failure of any Indemnified Party to
give such notice shall not relieve the Indemnifying Party of its obligations or liabilities pursuant to this Agreement, except (and only) to the extent that it shall be finally determined by a court of competent jurisdiction (which determination is
not subject to appeal or further review) that such failure shall have proximately and materially adversely prejudiced the Indemnifying Party. 

  
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 An Indemnified Party shall have the right to employ separate counsel in any such
Proceeding and to participate in the defense thereof, but the fees and expenses of such counsel shall be at the expense of such Indemnified Party or Parties unless: (i) the Indemnifying Party has agreed in writing to pay such fees and expenses;
or (ii) the Indemnifying Party shall have failed within 45 days of receiving notification of a Proceeding from an Indemnified Party to assume the defense of such Proceeding and to employ counsel reasonably satisfactory to such Indemnified Party
in any such Proceeding; or (iii) the named parties to any such Proceeding (including any impleaded parties) include both such Indemnified Party and the Indemnifying Party, and such Indemnified Party shall have been advised by counsel that a
conflict of interest is likely to exist if the same counsel were to represent such Indemnified Party and the Indemnifying Party (in which case, if such Indemnified Party notifies the Indemnifying Party in writing that it elects to employ separate
counsel at the expense of the Indemnifying Party, the Indemnifying Party shall not have the right to assume the defense thereof and the reasonable fees and expenses of separate counsel shall be at the expense of the Indemnifying Party). It being
understood, however, that the Indemnifying Party shall not, in connection with any one such Proceeding (including separate Proceedings that have been or will be consolidated before a single judge) be liable for the fees and expenses of more than one
separate firm of attorneys at any time for all Indemnified Parties, which firm shall be appointed by a majority of the Indemnified Parties. The Indemnifying Party shall not be liable for any settlement of any such Proceeding effected without its
written consent, which consent shall not be unreasonably withheld. No Indemnifying Party shall, without the prior written consent of the Indemnified Party, effect any settlement of any pending Proceeding in respect of which any Indemnified Party is
a party, unless such settlement includes an unconditional release of such Indemnified Party from all liability on claims that are the subject matter of such Proceeding. 

All reasonable fees and documented expenses of the Indemnified Party (including reasonable fees and expenses to the extent
incurred in connection with investigating or preparing to defend such Proceeding in a manner not inconsistent with this Section) shall be paid to the Indemnified Party, as incurred, within 20 Trading Days of written notice thereof to the
Indemnifying Party (regardless of whether it is ultimately determined that an Indemnified Party is not entitled to indemnification hereunder; provided, that the Indemnifying Party may require such Indemnified Party to undertake to reimburse all such
fees and expenses to the extent it is finally judicially determined that such Indemnified Party is not entitled to indemnification hereunder). 

(d) Contribution. If a claim for indemnification under Section 6.4(a) or (b) is unavailable
to an Indemnified Party (by reason of public policy or otherwise), then each Indemnifying Party, in lieu of indemnifying such Indemnified Party, shall contribute to the amount paid or payable by such Indemnified Party as a result of such Losses, in
such proportion as is appropriate to reflect the relative fault of the Indemnifying Party and Indemnified Party in connection with the actions, statements or omissions that resulted in such Losses as well as any other relevant equitable
considerations. The relative fault of such Indemnifying Party and Indemnified Party shall be determined by reference to, among other things, whether any action in question, including any untrue or alleged untrue statement of a material fact or
omission or alleged omission of a material fact, has been taken or made by, or relates to information supplied by, such Indemnifying Party or Indemnified Party, and the parties’ relative intent, knowledge, access to information and opportunity
to correct or prevent 

  
 37 

 
such action, statement or omission. The amount paid or payable by a party as a result of any Losses shall be deemed to include, subject to the limitations set forth in Section 6.4(c),
any reasonable attorneys’ or other reasonable fees or expenses incurred by such party in connection with any Proceeding to the extent such party would have been indemnified for such fees or expenses if the indemnification provided for in this
Section was available to such party in accordance with its terms. 
 The parties hereto agree that it would not be just and
equitable if contribution pursuant to this Section 6.4(d) were determined by pro rata allocation or by any other method of allocation that does not take into account the equitable considerations referred to in the immediately preceding
paragraph. Notwithstanding the provisions of this Section 6.4(d), no Investor shall be required to contribute, in the aggregate, any amount in excess of the amount by which the net proceeds actually received by such Investor from the
sale of the Registrable Securities subject to the Proceeding exceeds the amount of any damages that such Investor has otherwise been required to pay by reason of such untrue or alleged untrue statement or omission or alleged omission. No Person
guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the Securities Act) shall be entitled to contribution from any Person who was not guilty of such fraudulent misrepresentation. 

The indemnity and contribution agreements contained in this Section are in addition to any liability that the Indemnifying
Parties may have to the Indemnified Parties. 
 6.5 Dispositions. Each Investor agrees that it will comply with the prospectus
delivery requirements of the Securities Act as applicable to it in connection with sales of Registrable Securities pursuant to the Registration Statement and shall sell its Registrable Securities in accordance with the Plan of Distribution set forth
in the Prospectus. Each Investor further agrees that, upon receipt of a notice from the Company of the occurrence of any event of the kind described in Sections 6.2(c)(v), (vi) or (vii), such Investor will discontinue
disposition of such Registrable Securities under the Registration Statement until such Investor is advised in writing by the Company that the use of the Prospectus, or amended Prospectus, as applicable, may be used. The Company may provide
appropriate stop orders to enforce the provisions of this paragraph. Each Investor, severally and not jointly with the other Investors, agrees that the removal of the restrictive legend from certificates representing Securities as set forth in this
Section 4.1 is predicated upon the Company’s reliance that the Investor will comply with the provisions of this subsection. 

6.6 Piggy-Back Registrations. If at any time during the Effectiveness Period there is not an effective Registration Statement
covering all of the Registrable Securities and the Company shall determine to prepare and file with the SEC a registration statement relating to an offering for its own account or the account of others under the Securities Act of any of its equity
securities, other than on Form S-4 or Form S-8 (each as promulgated under the Securities Act) or their then equivalents relating to equity securities to be issued solely in connection with any acquisition of any entity or business or equity
securities issuable in connection with stock option or other employee benefit plans, then the Company shall send to each Investor not then eligible to sell all of their Registrable Securities without restriction or limitation under Rule 144
(including, without limitation, requirement to be in compliance with Rule 144(c)(1)), written notice of such determination and if, within ten days after receipt of such notice, any such Investor shall so request in writing, the

  
 38 

 
Company shall include in such registration statement all or any part of such Registrable Securities such Investor requests to be registered. Notwithstanding the foregoing, in the event
that, in connection with any underwritten public offering, the managing underwriter(s) thereof shall impose a limitation on the number of shares of Common Stock which may be included in the Registration Statement because, in such
underwriter(s)’ judgment, marketing or other factors dictate such limitation is necessary to facilitate public distribution, then the Company shall be obligated to include in such Registration Statement only such limited portion of the
Registrable Securities with respect to which such Investor has requested inclusion hereunder as the underwriter shall permit; provided, however, that (i) the Company shall not exclude any Registrable Securities unless the Company
has first excluded all outstanding securities, the holders of which are not contractually entitled to inclusion of such securities in such Registration Statement or are not contractually entitled to pro rata inclusion with the Registrable Securities
and (ii) after giving effect to the immediately preceding proviso, any such exclusion of Registrable Securities shall be made pro rata among the Investors seeking to include Registrable Securities and the holders of other securities having the
contractual right to inclusion of their securities in such Registration Statement by reason of demand registration rights, in proportion to the number of Registrable Securities or other securities, as applicable, sought to be included by each such
Investor or other holder. If an offering in connection with which an Investor is entitled to registration under this Section 6.7 is an underwritten offering, then each Investor whose Registrable Securities are included in such Registration
Statement shall, unless otherwise agreed by the Company, offer and sell such Registrable Securities in an underwritten offering using the same underwriter or underwriters and, subject to the provisions of this Agreement, on the same terms and
conditions as other shares of Common Stock included in such underwritten offering and shall enter into an underwriting agreement in a form and substance reasonably satisfactory to the Company and the underwriter or underwriters. Upon the
effectiveness the registration statement for which piggy-back registration has been provided in this Section 6.7, any Event Payments payable to an Investor whose Securities are included in such registration statement shall terminate. 

ARTICLE VII 
 MISCELLANEOUS 

7.1 Termination. This Agreement may be terminated by the Company or any Investor, by written notice to the other parties, if the
Closing has not been consummated by the third Business Day following the date of this Agreement; provided that no such termination will affect the right of any party to sue for any breach by the other party (or parties). 

7.2 Fees and Expenses. Except as expressly set forth in the Transaction Documents to the contrary, each party shall pay the fees and
expenses of its advisers, counsel, accountants and other experts, if any, and all other expenses incurred by such party incident to the negotiation, preparation, execution, delivery and performance of this Agreement. The Company shall pay all
Transfer Agent fees, stamp taxes and other taxes and duties levied in connection with the sale and issuance of their applicable Securities. 

  
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 7.3 Entire Agreement. The Transaction Documents, together with the Exhibits and Schedules
thereto, contain the entire understanding of the parties with respect to the subject matter hereof and supersede all prior agreements and understandings, oral or written, with respect to such matters, which the parties acknowledge have been merged
into such documents, exhibits and schedules. At or after the Closing, and without further consideration, the Company will execute and deliver to the Investors such further documents as may be reasonably requested in order to give practical effect to
the intention of the parties under the Transaction Documents. 
 7.4 Notices. Any and all notices or other communications or
deliveries required or permitted to be provided hereunder shall be in writing and shall be deemed given and effective on the earliest of (a) the date of transmission, if such notice or communication is delivered via facsimile or email at the
facsimile number or email address specified in this Section prior to 6:30 p.m. (New York City time) on a Trading Day, (b) the next Trading Day after the date of transmission, if such notice or communication is delivered via facsimile or email
at the facsimile number or email address specified in this Section on a day that is not a Trading Day or later than 6:30 p.m. (New York City time) on any Trading Day, (c) the Trading Day following the date of deposit with a nationally
recognized overnight courier service, or (d) upon actual receipt by the party to whom such notice is required to be given. The addresses, facsimile numbers and email addresses for such notices and communications are those set forth on the
signature pages hereof, or such other address or facsimile number as may be designated in writing hereafter, in the same manner, by any such Person. 

7.5 Amendments; Waivers. No provision of this Agreement may be waived or amended except in a written instrument signed, in the case of
an amendment, by the Company and each of the Investors or, in the case of a waiver, by the party against whom enforcement of any such waiver is sought. No waiver of any default with respect to any provision, condition or requirement of this
Agreement shall be deemed to be a continuing waiver in the future or a waiver of any subsequent default or a waiver of any other provision, condition or requirement hereof, nor shall any delay or omission of either party to exercise any right
hereunder in any manner impair the exercise of any such right. Notwithstanding the foregoing, a waiver or consent to depart from the provisions hereof with respect to a matter that relates exclusively to the rights of Investors under
Article VI may be given by Investors holding at least two-thirds (2/3) of the Registrable Securities to which such waiver or consent relates. 

7.6 Equal Treatment of Investors. No consideration (including any modification of any Transaction Document) shall be offered or paid to
any Person to amend or consent to a waiver or modification of any provision of the Transaction Documents unless the same consideration is also offered to all of the parties to such Transaction Documents. For clarification purposes, this provision
constitutes a separate right granted to each Investor by the Company and negotiated separately by each Investor, and is intended for the Company to treat the Investors as a class and shall not in any way be construed as the Investors acting in
concert or as a group with respect to the purchase, disposition or voting of Securities or otherwise. 
 7.7 Construction. The
headings herein are for convenience only, do not constitute a part of this Agreement and shall not be deemed to limit or affect any of the provisions hereof. The language used in this Agreement will be deemed to be the language chosen by the parties
to express their mutual intent, and no rules of strict construction will be applied against any party. 

  
 40 

 7.8 Successors and Assigns. This Agreement shall be binding upon and inure to the benefit
of the parties and their successors and permitted assigns. The Company may not assign this Agreement or any rights or obligations hereunder without the prior written consent of the Investors. Any Investor may assign its rights under this Agreement
to any Person to whom such Investor assigns or transfers any Securities, provided (i) such transferor agrees in writing with the transferee or assignee to assign such rights, and a copy of such agreement is furnished to the Company after such
assignment, (ii) the Company is furnished with written notice of (x) the name and address of such transferee or assignee and (y) the Registrable Securities with respect to which such registration rights are being transferred or
assigned, (iii) following such transfer or assignment, the further disposition of such securities by the transferee or assignee is restricted under the Securities Act and applicable state securities laws, (iv) such transferee agrees in
writing to be bound, with respect to the transferred Securities, by the provisions hereof that apply to the “Investors” and (v) such transfer shall have been made in accordance with the applicable requirements of this Agreement and
with all laws applicable thereto. 
 7.9 Persons Entitled to Benefit of Agreement. This Agreement shall inure to the benefit of and
be binding upon the Company and each Investor and their respective successors and permitted assigns. Nothing expressed or mentioned in this Agreement is intended or shall be construed to give any person, other than those persons mentioned in the
preceding sentence or otherwise explicitly mentioned in this Agreement, any legal or equitable right, remedy or claim under or in respect of this Agreement, or any provisions herein contained, this Agreement and all conditions and provisions hereof
being intended to be and being for the sole and exclusive benefit of such persons and for the benefit of no other person; except that (i) each Indemnified Party is an intended third party beneficiary of Section 6.4 and
Section 7.19 and (in each case) may enforce the provisions of such Sections directly against the parties with obligations thereunder and (ii) the Agents are intended third party beneficiaries of the representations and warranties of
the Company and the Investors in Article III. 
 7.10 Governing Law; Venue; Waiver of Jury Trial. ALL QUESTIONS CONCERNING THE
CONSTRUCTION, VALIDITY, ENFORCEMENT AND INTERPRETATION OF THIS AGREEMENT SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK. THE COMPANY AND INVESTORS HEREBY IRREVOCABLY SUBMIT TO THE NON-EXCLUSIVE JURISDICTION
OF THE STATE AND FEDERAL COURTS SITTING IN THE CITY OF NEW YORK, BOROUGH OF MANHATTAN FOR THE ADJUDICATION OF ANY DISPUTE BROUGHT BY THE COMPANY OR ANY INVESTOR HEREUNDER, IN CONNECTION HEREWITH OR WITH ANY TRANSACTION CONTEMPLATED HEREBY OR
DISCUSSED HEREIN (INCLUDING WITH RESPECT TO THE ENFORCEMENT OF ANY OF THE TRANSACTION DOCUMENTS), AND HEREBY IRREVOCABLY WAIVE, AND AGREE NOT TO ASSERT IN ANY SUIT, ACTION OR PROCEEDING BROUGHT BY THE COMPANY OR ANY INVESTOR, ANY CLAIM THAT IT IS
NOT PERSONALLY SUBJECT TO THE JURISDICTION OF ANY SUCH COURT, OR THAT SUCH SUIT, ACTION OR PROCEEDING IS IMPROPER. EACH PARTY HEREBY IRREVOCABLY WAIVES PERSONAL SERVICE OF PROCESS AND CONSENTS TO PROCESS BEING SERVED IN ANY SUCH SUIT, ACTION OR
PROCEEDING BY MAILING A COPY THEREOF VIA REGISTERED OR CERTIFIED MAIL OR OVERNIGHT DELIVERY (WITH EVIDENCE OF DELIVERY) TO SUCH PARTY AT THE ADDRESS IN EFFECT FOR 

  
 41 

 
NOTICES TO IT UNDER THIS AGREEMENT AND AGREES THAT SUCH SERVICE SHALL CONSTITUTE GOOD AND SUFFICIENT SERVICE OF PROCESS AND NOTICE THEREOF. NOTHING CONTAINED HEREIN SHALL BE DEEMED TO LIMIT IN
ANY WAY ANY RIGHT TO SERVE PROCESS IN ANY MANNER PERMITTED BY LAW. THE COMPANY AND INVESTORS HEREBY WAIVE ALL RIGHTS TO A TRIAL BY JURY. 

7.11 Survival. The representations and warranties, agreements and covenants contained herein shall survive the Closing. 

7.12 Execution. This Agreement may be executed in two or more counterparts, all of which when taken together shall be considered one
and the same agreement and shall become effective when counterparts have been signed by each party and delivered to the other party, it being understood that both parties need not sign the same counterpart. In the event that any signature is
delivered by facsimile transmission or email attachment, such signature shall create a valid and binding obligation of the party executing (or on whose behalf such signature is executed) with the same force and effect as if such facsimile or
email-attached signature page were an original thereof. 
 7.13 Severability. If any provision of this Agreement is prohibited by law
or otherwise determined to be invalid or unenforceable by a court of competent jurisdiction, the provision that would otherwise be prohibited, invalid or unenforceable shall be deemed amended to apply to the broadest extent that it would be valid
and enforceable, and the invalidity or unenforceability of such provision shall not affect the validity of the remaining provisions of this Agreement so long as this Agreement as so modified continues to express, without material change, the
original intentions of the parties as to the subject matter hereof and the prohibited nature, invalidity or unenforceability of the provision(s) in question does not substantially impair the respective expectations or reciprocal obligations of the
parties or the practical realization of the benefits that would otherwise be conferred upon the parties. The parties will endeavor in good faith negotiations to replace the prohibited, invalid or unenforceable provision(s) with a valid provision(s),
the effect of which comes as close as possible to that of the prohibited, invalid or unenforceable provision(s). 
 7.14 Rescission and
Withdrawal Right. Notwithstanding anything to the contrary contained in (and without limiting any similar provisions of) the Transaction Documents, whenever any Investor exercises a right, election, demand or option owed to such Investor by the
Company under a Transaction Document and the Company does not timely perform its related obligations within the periods therein provided, then, prior to the performance by the Company of the Company’s related obligation, such Investor may
rescind or withdraw, in its sole discretion from time to time upon written notice to the Company, any relevant notice, demand or election in whole or in part without prejudice to its future actions and rights. 

7.15 Replacement of Securities. If any certificate or instrument evidencing any Securities is mutilated, lost, stolen or destroyed, the
Company shall issue or cause to be issued in exchange and substitution for and upon cancellation thereof, or in lieu of and substitution therefor, a new certificate or instrument, but only upon receipt of evidence reasonably satisfactory to the
Company of such loss, theft or destruction and the execution by the holder thereof of a customary lost certificate affidavit of that fact and an agreement to indemnify and hold harmless the Company for any losses in connection therewith. The
applicants for a new certificate or instrument under such circumstances shall also pay any reasonable third-party costs associated with the issuance of such replacement Securities. 

  
 42 

 7.16 Remedies. In addition to being entitled to exercise all rights provided herein or
granted by law, including recovery of damages, each of the Investors and the Company will be entitled to seek specific performance under the Transaction Documents. The parties agree that monetary damages may not be adequate compensation for any loss
incurred by reason of any breach of obligations described in the foregoing sentence and hereby agrees to waive in any action for specific performance of any such obligation (other than in connection with any action for temporary restraining order)
the defense that a remedy at law would be adequate. 
 7.17 Adjustments in Share Numbers and Prices. In the event of any stock split,
subdivision, dividend or distribution payable in shares of Common Stock (or other securities or rights convertible into, or entitling the holder thereof to receive directly or indirectly shares of Common Stock), combination or other similar
recapitalization or event occurring after the date hereof and prior to the Closing, each reference in any Transaction Document to a number of shares or a price per share shall be amended to appropriately account for such event. 

7.18 Independent Nature of Investors’ Obligations and Rights. The obligations of each Investor under any Transaction Document are
several and not joint with the obligations of any other Investor, and no Investor shall be responsible in any way for the performance of the obligations of any other Investor under any Transaction Document. The decision of each Investor to purchase
Securities pursuant to this Agreement has been made by such Investor independently of any other Investor and independently of any information, materials, statements or opinions as to the business, affairs, operations, assets, properties,
liabilities, results of operations, condition (financial or otherwise) or prospects of the Company which may have been made or given by any other Investor or by any agent or employee of any other Investor, and no Investor or any of its agents or
employees shall have any liability to any other Investor (or any other person) relating to or arising from any such information, materials, statements or opinions. Nothing contained herein or in any Transaction Document, and no action taken by any
Investor pursuant thereto, shall be deemed to constitute the Investors as a partnership, an association, a joint venture or any other kind of entity, or create a presumption that the Investors are in any way acting in concert or as a group with
respect to such obligations or the transactions contemplated by the Transaction Document. Each Investor acknowledges that no other Investor has acted as agent for such Investor in connection with making its investment hereunder and that no other
Investor will be acting as agent of such Investor in connection with monitoring its investment hereunder. Each Investor shall be entitled to independently protect and enforce its rights, including without limitation the rights arising out of this
Agreement or out of the other Transaction Documents, and it shall not be necessary for any other Investor to be joined as an additional party in any proceeding for such purpose. 

7.19 Indemnity of Agents. Each party hereto agrees for the express benefit of the Agents, their affiliates and representatives that:

 (a) the Agents or any of their respective affiliates or representatives (i) shall not have any duties or obligations other than
those specifically set forth herein or in the engagement 

  
 43 

 
letter between the Company and the Agents (the “Engagement Letter”), and (ii) shall not be liable (x) for any action taken, suffered or omitted by the Agents in good
faith and reasonably believed to be authorized or within the discretion or rights or powers conferred upon them by this Agreement or any Transaction Document or (y) for anything which the Agents may do or refrain from doing in connection with
this Agreement or any Transaction Document, except for the Agent’s own willful misconduct or bad faith or that of its affiliates or representatives. 

(b) the Agents and any of their respective affiliates or representatives shall be entitled to (i) rely on, and shall be protected in
acting upon any certificate, instrument, opinion, notice, letter or any other document or security delivered to any of them by or on behalf of the Company and (ii) be indemnified by the Company for acting as Agent hereunder pursuant to the
indemnification provisions set forth in the Engagement Letter, which are hereby incorporated by reference herein. 
 [SIGNATURE PAGES TO
FOLLOW] 

  
 44 

 IN WITNESS WHEREOF, the parties hereto have caused this Securities Purchase Agreement to be duly
executed by their respective authorized signatories as of the date first indicated above. 
  

			
	CAREDX, INC.
		
	By:	 	  

	Name:
	Title:
	
	Address for Notice:
	
	Facsimile No.:
	Telephone No.:
	Attn:

  

					
		  	 With a copy to: Wilson Sonsini Goodrich & Rosati, Professional Corporation

Facsimile: (650) 493-6811
 Telephone: (650) 493.9300

Attn: Michael Danaher

		  
		  
		  

 COMPANY SIGNATURE PAGE 

 Investor Signature Page 

By its execution and delivery of this signature page, the undersigned Investor hereby joins in and agrees to be bound by the terms and
conditions of the Securities Purchase Agreement dated as of April 12, 2016 (the “Purchase Agreement”) by and among CareDx, Inc. and the Investors (as defined therein), as to the number of Units set forth below, and authorizes this
signature page to be attached to the Purchase Agreement or counterparts thereof. 
  

			
	Name of Investor:
	
	                                    
                                         
         
		
	By:	 	                                     
                                         
  
		 	Name                                     
                       Title:
	
	Address:
                                         
                             
	
	                                    
                                         
         
	
	Telephone No.:
                                         
                   
	
	Facsimile No.:
                                         
                    
	
	Email Address:
	
	                                    
                                         
         
	
	Number of Units:
                                         
               
	
	Purchase Price Per Unit: $23.94
	
	Aggregate Purchase Price:
$                                        

 Exhibits: 
  

			
	A	  	Schedule of Investors
	B	  	Form of Certificate of Designation
	C	  	Instruction Sheet for Investors
	D	  	Opinion of Company Corporate Counsel
	E	  	Plan of Distribution
	F	  	Selling Stockholders
	F-1	  	Company Transfer Agent Instructions
	F-2	  	Form of Notice of Effectiveness of Registration Statement
	G	  	Form of Warrant
	H	  	Form of Voting Agreement
	I	  	Schedules

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