Document:

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                                                                   EXHIBIT 10.14

                           LOAN AND SECURITY AGREEMENT

     THIS LOAN AND SECURITY AGREEMENT No. 3561 (this "AGREEMENT") is entered
into as of May 21,2003, by and between LIGHTHOUSE CAPITAL PARTNERS IV, L.P.
("LENDER") AND NEUROMETRIX, INC., a Delaware corporation ("BORROWER").

                                    RECITALS

     Borrower wishes to borrow money from time to time from Lender and Lender
desires to lend money to Borrower. This Agreement sets forth the terms on which
Lender will lend to Borrower and Borrower will repay the loan to Lender.

                                    AGREEMENT

     The parties agree as follows:

     1.     DEFINITIONS AND CONSTRUCTION

            1.1    DEFINITIONS. As used in this Agreement, the following terms
shall have the following definitions:

     "ADVANCE" means each extension of credit by Lender to Borrower under this
Agreement.

     "AFFILIATE" means any Person that owns or controls directly or indirectly
five percent (5%) or more of the stock of another entity, any Person that
controls or is controlled by or is under common control with such Persons or any
Affiliate of such Persons or each of such Person's officers, directors, joint
venturers or partners.

     "BASIC RATE" means a PER ANNUM fixed rate of interest (based on a year of
360 days and actual days elapsed) equal to eleven percent (11%).

     "BORROWER'S BOOKS" means all of Borrower's books and records including:
ledgers; records concerning Borrower's assets or liabilities, the Collateral,
business operations or financial condition; and all computer programs, or tape
files, and the equipment, containing such information.

     "BUSINESS DAY" means any day that is not a Saturday, Sunday, or other day
on which banks in the State of California are authorized or required to close.

     "CODE" means the Uniform Commercial Code as adopted and in effect in the
State of California, as amended from time to time.

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     "COLLATERAL" means the Property described on EXHIBIT A-1 attached hereto.

     "COMMITMENT" means $3,000,000.00.

     "COMMITMENT TERMINATION DATE" means December 31, 2003.

     "CONTINGENT OBLIGATION" means, as applied to any Person, any direct or
indirect liability, contingent or otherwise; of that Person with respect to any
indebtedness, lease, dividend, letter of credit or other obligation in each case
of another, including any such obligation directly or indirectly guaranteed,
endorsed (otherwise than for collection or deposit in the ordinary course of
business), co-made or discounted or sold with recourse by that Person, or in
respect of which that Person is otherwise directly or indirectly liable. The
amount of any Contingent Obligation shall be equal to the amount of the
obligation so guaranteed or otherwise supported.

     "CONTROL AGREEMENT" means an agreement in the form of EXHIBIT A-2 attached
hereto executed by Lender, Borrower and each applicable financial institution
and/or securities/investment intermediary in which such financial institution
and/or intermediary agrees that Lender has a security interest in any account of
Borrower.

     "DEFAULT" means any event which with the passing of time or the giving of
notice or both would become an Event of Default hereunder.

     "DEFAULT RATE" means the PER ANNUM rate of interest equal to fourteen
percent (14%), but such rate shall in no event be more than the highest rate
permitted by applicable law to be charged on commercial loans.

     "EVENT OF DEFAULT" has the meaning given to such term in Section 8.

     "FACILITY FEE" has the meaning given to such term in Section 25(a).

     "FINAL PAYMENT" means eleven percent (11%) of the amount of the Advances
hereunder.

     "FUNDING DATE" means any date on which an Advance is made to or on account
of Borrower under this Agreement.

     "GOVERNMENTAL AUTHORITY" means (a) any federal, state, county, municipal or
foreign, government, or political subdivision thereof, (b) any governmental or
quasi-governmental agency, authority, board, bureau, commission, department,
instrumentality or public body, (c) any court or administrative tribunal or (d)
with respect to any Person, any arbitration tribunal or other non-governmental
authority to whose jurisdiction that Person has consented.

     "INDEBTEDNESS" means (a) all indebtedness for borrowed money or the
deferred purchase price of Property or services, including reimbursement and
other obligations with respect to surety bonds and letters of credit, (b) all
obligations evidenced by notes, bonds, debentures or similar instruments, (c)
all capital lease obligations, and (d) all Contingent Obligations.

     "INTELLECTUAL PROPERTY SECURITY AGREEMENT" means an agreement in the form
of EXHIBIT D or such other form as Lender may agree to accept.

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     "INTERIM PAYMENT" has the meaning given to such term in Section 2.4(b).

     "LENDER'S EXPENSES" means all reasonable costs or expenses (including
reasonable attorneys' fees and expenses) incurred in connection with the
preparation and negotiation (in an amount not to exceed $10,000.00) and
enforcement of the Loan Documents; and Lender's reasonable attorneys' fees and
expenses incurred in amending, modifying, enforcing or defending the Loan
Documents, including in the exercise of any rights or remedies afforded
hereunder or under applicable law, whether or not suit is brought.

     "LIEN" means any pledge, bailment, lease, mortgage, hypothecation,
conditional sales and title retention agreement, charge, claim, encumbrance or
other lien in favor of any Person.

     "LOAN COMMENCEMENT DATE" means the first day of the calendar month next
following the six (6) month anniversary of the Funding Date of an Advance.

     "LOAN DOCUMENTS" means, collectively, this Agreement, the Warrant, and all
other documents, instruments and agreements entered into between Borrower and
Lender in connection with this Agreement, all as amended or extended from time
to time.

     "LOAN REPAYMENT FACTOR" means an amount equal to 3.7930%.

     "MATERIAL ADVERSE CHANGE" means in Lender's sole judgment, that there has
been, or will imminently occur: (i) a material adverse change in the general
affairs, management, results of operations, condition (financial or otherwise)
or prospects of Borrower, whether or not arising from transactions in the
ordinary course of business, or (ii) a material adverse deviation by Borrower in
the conduct of its business as now conducted; or (iii) a material impairment of
the value of the Collateral or the priority of Lender's security interests in
the Collateral, or (iv) a material impairment of the prospect of repayment of
any portion of the Obligations.

     "MATURITY DATE" means, with respect to each Advance, the last day of the
Repayment Period for such Advance, or if earlier, the date of prepayment under
Section 2.6.

     "MINIMUM FUNDING AMOUNT" means $500,000.00.

     "NOTICE OF BORROWING" means a supplement to this Agreement in substantially
the form of EXHIBIT C.

     "OBLIGATIONS" means all debt, principal, interest, fees, charges, expenses
and attorneys' fees and costs and other amounts, obligations, covenants, and
duties owing by Borrower to Lender of any kind and description (whether pursuant
to or evidenced by the Loan Documents, or by any other agreement between Lender
and Borrower, and whether or not for the payment of money), whether direct or
indirect, absolute or contingent, due or to become due, now existing or
hereafter arising, including the principal and interest due with respect to the
Advances, and including any debt, liability, or obligation owing from Borrower
to others that Lender may have obtained by assignment or otherwise (but only
such debts, liabilities or obligations that were consented to by the Borrower as
being Obligations hereunder), and further including all interest not paid when
due and all Lender's Expenses that Borrower is required to pay or reimburse by
the Loan Documents, by law, or otherwise.

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     "PAYMENT DATE" has the meaning given to that term in Section 2.4(a).

     "PERMITTED INDEBTEDNESS" means the following:

            (a)    any loans made from time to time by Lender, and

            (b)    Indebtedness secured by the Permitted Liens in SECTION (b) of
the definition of Permitted Liens, as approved by Lender in its sole discretion;

            (c)    Indebtedness incurred in the ordinary course of business with
respect to the deferred purchase price of Property or services provided such
Indebtedness does not cause any Liens other than Permitted Liens to arise; and

            (d)    Indebtedness existing on the date hereof and disclosed on
SCHEDULE 3.

     "PERMITTED INVESTMENTS" means the following:

            (a)    investments shown on SCHEDULE 3 and existing as of the date
hereof;

            (b)    (i) marketable direct obligations issued or unconditionally
guaranteed by the United States or its agency or any State maturing within one
(1) year from its acquisition, (ii) commercial paper maturing no more than one
(1) year after its creation and having the highest rating from either Standard &
Poor's Corporation or Moody's Investor Service, Inc., and (iii) bank
certificates of deposit issued maturing no more than one (1) year after issue;
and (iv) shares of any so-called "money market fund" or any mutual fund which
has at least 85% of its assets invested in investments of the type described in
clauses (i), (ii), or (iii) above.

            (c)    investments consisting of the endorsement of negotiable
instruments for deposit or collection or similar transaction in the ordinary
course of business;

            (d)    investments accepted in connection with transfers permitted
by SECTION 7.2;

            (e)    investments consisting of (i) travel advances and employee
relocation loans and other employee loans and advances in the ordinary course of
business, and (ii) loans to employees, officers or directors relating to the
purchase of equity securities of Borrower or its Subsidiaries pursuant to
employee stock purchase plans or agreements approved by Borrower's Board of
Directors;

            (f)    investments (including debt obligations) received in
connection with the bankruptcy or reorganization of customers and suppliers and
in settlement of delinquent

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obligations of, and other disputes with, customers or suppliers arising in the
ordinary course of business, PROVIDED HOWEVER, the amount as set forth in this
paragraph (f) shall not exceed Two Hundred Fifty Thousand Dollars ($250,000) in
the aggregate;

            (g)    investments consisting of notes receivable of, or prepaid
royalties and other credit extensions, to customers and suppliers who are not
Affiliates, in the ordinary course of business; PROVIDED that this paragraph (g)
shall not apply to investments of Borrower in any Subsidiary; and

            (h)    investments in joint ventures that include (i) the licensing
or development of intellectual property or (ii) providing of technical support,
in each case consistent with the conduct of Borrower's business as now conducted
or proposed to be conducted and PROVIDED no Liens other than Permitted Liens
arise as a result thereof.

     "PERMITTED LIENS" means the following:

            (a)    The Lien created by this Agreement;

            (b)    Any Liens existing as of the date hereof and disclosed in
SCHEDULE 1;

            (c)    Liens for taxes, fees, assessments or other governmental
charges or levies, either not delinquent or being contested in good faith by
appropriate proceedings;

            (d)    Liens to secure payment of worker's compensation, employment
insurance, old age pensions or other social security obligations of Borrower in
the ordinary course of business of Borrower, and

            (e)    Liens incurred in connection with the extension, renewal or
refinancing of the indebtedness secured by Liens of the type described in clause
(b) above, PROVIDED that any extension, renewal or replacement Lien shall be
limited to the Property encumbered by the existing Lien and the principal amount
of the indebtedness being extended, renewed or refinanced does not increase.

     "PERSON" means and includes any individual, any partnership, any
corporation, any business trust, any joint stock company, any limited liability
company, any unincorporated association or any other entity and any domestic or
foreign national, state or local government, any political subdivision thereof,
and any department, agency, authority or bureau of any of the foregoing.

     "PROPERTY" means any interest in any kind of property or asset, whether
real, personal or mixed, whether tangible or intangible.

     "REPAYMENT PERIOD" means the period beginning on the Loan Commencement Date
and continuing for thirty (30) calendar months.

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     "RESPONSIBLE OFFICER" means each of the President and the Chief Financial
Officer of Borrower or such other Person as Borrower shall in writing certify to
Lender as being a Responsible Officer.

     "SCHEDULED PAYMENTS" has the meaning given to such term in SECTION 2.4(a).

     "SUBSIDIARY" means any corporation of which a majority of the outstanding
capital stock entitled to vote for the election of directors (otherwise than as
the result of a default) is owned by Borrower directly or indirectly through
Subsidiaries.

     "TERM" means the period from and after the date hereof until the payment in
full of all amounts and liabilities payable under this Agreement and the other
Loan Documents, including principal and interest on the Advances.

     "WARRANT" means the Warrant in favor of Lender to purchase securities of
Borrower substantially in the form of EXHIBIT B.

            1.2    OTHER INTERPRETIVE PROVISIONS. References in this Agreement
to "Articles," "Sections," "Exhibits," "Schedules" and "Annexes" are to
recitals, articles, sections, exhibits, schedules and annexes herein and hereto
unless otherwise indicated. References in this Agreement and each of the other
Loan Documents to any document, instrument or agreement shall include (a) all
exhibits, schedules, annexes and other attachments thereto, (b) all documents,
instruments or agreements issued or executed in replacement thereof, and (c)
such document, instrument or agreement, or replacement or predecessor thereto,
as amended, modified and supplemented from time to time and in effect at any
given time. The words "hereof," "herein" and "hereunder" and words of similar
import when used in this Agreement or any other Loan Document shall refer to
this Agreement or such other Loan Document, as the case may be, as a whole and
not to any particular provision of this Agreement or such other Loan Document,
as the case may be. The words "include" and "including" and words or similar
import when used in this Agreement or any other Loan Document shall not be
construed to be limiting or exclusive. Unless otherwise indicated in this
Agreement or any other Loan Document, all accounting terms used in this
Agreement or any other Loan Document shall be construed, and all accounting and
financial computations hereunder or thereunder shall be computed, in accordance
with generally accepted accounting principles as in effect in the United States
of America from time to time.

     2.     LOAN AND TERMS OF PAYMENT

            2.1    COMMITMENT. Subject to the terms and conditions of this
Agreement and relying upon the representations and warranties herein set forth
as and when made or deemed to be made, Lender agrees to lend to Borrower, from
time to time prior to the Commitment Termination Date, the Advances; PROVIDED
that the aggregate principal amount of the Advances shall not exceed the
Commitment at such time. If prepaid, the principal of the Advances may not be
re-borrowed.

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            2.2    USE OF PROCEEDS; THE ADVANCES.

                   (a)    USE OF PROCEEDS. The proceeds of the Advances shall be
used solely for working capital purposes.

                   (b)    THE ADVANCES. The Advances shall be repayable in
consecutive monthly installments in accordance with the terms of SECTION 2.4.
Lender may, and is hereby authorized by Borrower to, endorse in Lender's books
and records appropriate notations regarding Lender's interest in the Advances;
PROVIDED, HOWEVER, that the failure to make, or an error in making, any such
notation shall not limit or otherwise affect the Obligations of Borrower
hereunder.

            2.3    PROCEDURE FOR MAKING ADVANCES.

                   (a)    NOTICE. Whenever Borrower desires that Lender make an
Advance, Borrower shall so notify Lender in writing (or by telephone with prompt
confirmation in writing) at least five (5) Business Days in advance of the
desired Funding Date, which notice shall be irrevocable. Each such notification
shall be promptly confirmed by a Notice of Borrowing in substantially the form
of EXHIBIT C hereto. Lender's obligation to make Advances shall be expressly
subject to the satisfaction of the conditions set forth in SECTIONS 3.1 and 3.2.

                   (b)    INTEREST RATE. Borrower shall pay interest on the
unpaid principal amount of each Advance from the date of the Advance until such
Advance has been paid in full, at a PER ANNUM rate of interest equal to the
Basic Rate. All computations of interest on each Advance shall be based on a
year of 360 days for actual days elapsed. Notwithstanding any other provision
hereof, the amount of interest payable hereunder shall not in any event exceed
the maximum amount permitted by the law applicable to interest charged on
commercial loans.

                   (c)    DISBURSEMENT. Subject to the satisfaction of the
conditions set forth in SECTIONS 3.1 and 3.2 with respect to the initial Advance
and the satisfaction of the conditions set forth in SECTION 3.2 with respect to
each subsequent Advance, Lender shall disburse the Advances.

                   (d)    TERMINATION OF COMMITMENT TO LEND. Notwithstanding
anything in the Loan Documents; Lender's obligation to lend the undisbursed
portion of the Commitment to Borrower hereunder shall terminate on the earlier
of (i) at the Lender's sole election, the occurrence and continuance of any
Event of Default hereunder, and (ii) the Commitment Termination Date.

            2.4    AMORTIZATION OF PRINCIPAL AND INTEREST; INTERIM PAYMENT,
FINAL PAYMENT.

                   (a)    PRINCIPAL AND INTEREST PAYMENTS ON PAYMENT DATES.
Borrower shall make payments of principal in advance and interest monthly in
advance for each Advance

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(collectively, "SCHEDULED PAYMENTS"), commencing on the Loan Commencement Date
with respect to such Advance and continuing thereafter during the Repayment
Period on the first Business Day of each month (each a "PAYMENT DATE"), in an
amount equal to the Loan Repayment Factor multiplied by the amount of the
Advance as of the Loan Commencement Date. In any event, all unpaid principal and
accrued interest shall be due and payable in full on the last Payment Date with
respect to such Advance.

                   (b)    INTERIM PAYMENT. In addition to the Scheduled
Payments, Borrower shall pay to Lender, monthly in advance, an amount (the
"INTERIM PAYMENT") equal to accrued interest on the principal amount of each
Advance calculated at the Basic Rate from the Funding Date of such Advance (and
thereafter recalculated on the first Business Day of each calendar month during
which an Interim Payment is due), until commencement of the Repayment Period
with respect to the Advance.

                   (c)    FINAL PAYMENT. In addition to unpaid principal and
accrued interest and all other amounts due on such date, Borrower shall pay the
Final Payment with respect to the Advances on the Maturity Date with respect to
each Advance, unless sooner paid under SECTION 2.6(b).

            2.5    FEES. Borrower shall pay to Lender the following:

                   (a)    FACILITY FEE. A Facility Fee equal to one percent (1%)
of each Advance amount shall be due and payable on the Funding Date of such
Advance and shall be fully earned and non-refundable as of such date;

                   (b)    COMMITMENT FEE. A Commitment Fee equal to Ten Thousand
Dollars ($10,000) which has been paid by Borrower to Lender, which fee shall be
applied to amounts due under the Agreement;

                   (c)    LATE FEE. A late charge on any Scheduled Payments or
other sums due hereunder which are past due, in an amount equal to two percent
(2%) of the past due amount payable on demand.

            2.6    PREPAYMENTS.

                   (a)    MANDATORY PREPAYMENT UPON AN ACCELERATION. If the
Advances are accelerated following the occurrence of an Event of Default, then
Borrower shall immediately pay to Lender (i) all unpaid Interim Payments and/or
Scheduled Payments with respect to the Advances due prior to the date of
prepayment, (ii) the outstanding principal amount of the Advances and any unpaid
accrued interest, (iii) the Final Payment, and (iv) all other sums, if any, that
shall have become due and payable hereunder with respect to the Advances.

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                   (b)    VOLUNTARY PREPAYMENT. Borrower may voluntarily prepay
the Advances or prepay in total any particular Advance, PROVIDED that each of
the following conditions is satisfied: Borrower pays to Lender (i) all unpaid
Interim Payments and/or Scheduled Payments with respect to the Advances being
prepaid which are due prior to the date of prepayment, (ii) the outstanding
principal amount of the Advances being prepaid and any unpaid accrued interest
(iii) the Final Payment with respect to the Advances being prepaid, and (iv) all
other sums, if any, that shall have become due and payable hereunder with
respect to the Advances. Lender shall not be required to accept the Partial
prepayment of any Advance.

                   (c)    NO OTHER PREPAYMENT. Borrower may not prepay any
Advance except pursuant to SECTION 2.6 (a) AND (b) above in which event the
prepayment shall be made as described in such section.

            2.7    OTHER PAYMENT TERMS.

                   (a)    PLACE AND MANNER. Borrower shall make all payments due
to Lender by payments to Lender at the address specified in SECTION 11, in
lawful money of the United States and in same day or immediately available
funds.

                   (b)    DATE. Whenever any payment due hereunder shall fall
due on a day other than a Business Day, such payment shall be made on the next
succeeding Business Day, and such extension of time shall be included in the
computation of interest or fees, as the case may be.

                   (c)    DEFAULT RATE. If either (i) any amounts required to be
paid by Borrower under this Agreement or the other Loan Documents, (including
principal, interest; and any fees or other amounts) remain unpaid after such
amounts are due, or (ii) an Event of Default has occurred and is continuing,
Borrower shall pay interest on the aggregate, outstanding balance hereunder from
the date due or from the date of the Event of Default, as applicable, until such
past due amounts are paid in full or until all Events of Default are cured, as
applicable, at a PER ANNUM rate equal to the Default Rate. All computations of
such interest shall be based on a year of 360 days for actual days elapsed.

            2.8    MINIMUM FUNDING AMOUNT{the "MINIMUM FUNDING AMOUNT"}. Except
with the prior consent of Lender, in Lender's sole discretion, the amount of the
requested Advance shall not be less than the Minimum Funding Amount.

            2.9    CREDITING PAYMENTS. The receipt by Lender of any wire
transfer of funds, check, or other item of payment shall be immediately applied
conditionally to reduce Obligations, but shall not be considered a payment on
account unless such wire transfer is of immediately available federal funds and
is made to the appropriate deposit account of Lender or unless and until such
check or other item of payment is honored when presented for payment.
Notwithstanding anything to the contrary contained herein, any wire transfer or
payment

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received by Lender after 11:00 a.m. California time shall be deemed to
have been received by Lender as of the opening of business on the immediately
following Business Day.

            2.10   TERM. This Agreement shall become effective upon acceptance
by Lender and shall continue in full force and effect for a term ending on the
Maturity Date of the final Advance; provided however, that nothing in this
SECTION 2.10 shall be deemed to modify or limit Lender's rights and remedies
with respect to the collection or enforcement of any Obligations which are
outstanding at such time, or the enforcement of Lender's rights and remedies if
an Event of Default has occurred or is continuing at such time, or Lender's
ability to assert any indemnity claims against Borrower.

     3.     CONDITIONS OF ADVANCES

            3.1    CONDITIONS PRECEDENT TO INITIAL ADVANCE. The obligation of
Lender to make the initial Advance is subject to the condition precedent that
Lender shall have received, in form and substance satisfactory to Lender, all of
the following:

                   (a)    This Agreement duly executed by Borrower.

                   (b)    The Warrant to be issued to Lender duly executed by
Borrower.

                   (c)    The Intellectual Property Security Agreement to be
issued to Lender duly executed by Borrower.

                   (d)    Copies of the contracts and agreements referenced in
SECTION 5.14, and any third party consents related thereto required by the terms
thereof in connection with Borrower's performance of the Loan Documents.

                   (e)    An officer's certificate of Borrower with copies of
the following documents attached: (i) the certificate of incorporation and
by-laws of Borrower certified by Borrower as being in full force and effect on
the Funding Date, (ii) incumbency and representative signatures, and (iii)
resolutions authorizing the execution and delivery of this Agreement and each of
the other Loan Documents.

                   (f)    A good standing certificate from Borrower's state of
incorporation and the state in which Borrower's principal place of business is
located, together with certificates of the applicable governmental authorities
stating that Borrower is in compliance with the franchise tax laws of each such
state, each dated as of a recent date.

                   (g)    Evidence of the insurance coverage required by SECTION
6.8 of this Agreement.

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                   (h)    Payment of any unreimbursed Lender's Expenses not to
exceed $10,000.00; provided that the Commitment Fee shall be applied to such
payment.

                   (i)    All necessary consents of shareholders and other third
parties with respect to the execution, delivery and performance of this
Agreement, the Warrant and the other Loan Documents.

                   (j)    Such other documents, and completion of such other
matters, as Lender may deem necessary or appropriate.

            3.2    CONDITIONS PRECEDENT TO ALL ADVANCES. The obligation of
Lender to make each Advance, including the initial Advance, is further subject
to the following conditions:

                   (a)    A certificate executed and delivered in favor of
Lender that no Default or Event of Default shall have occurred or is continuing.

                   (b)    Borrower shall have executed a Notice of Borrowing
with respect to the proposed Advance.

                   (c)    The Pledge and Security Agreement between Borrower and
Comerica Bank shall have been executed and delivered by each of Comerica Bank
and the Borrower to the other.

                   (d)    Lender shall have received such documents, instruments
and agreements, including UCC financing statements or amendments to UCC
financing statements, as Lender shall reasonably request to evidence the
perfection and priority of the security interests granted to Lender pursuant to
SECTION 4, including the filing of UCC termination statements terminating the
UCC financing statements naming Comerica Bank as secured party, as filed in the
jurisdiction of Massachusetts.

                   (e)    Borrower shall have delivered to Lender a
subordination agreement, release, or estoppel letter, as appropriate, from any
Person having an existing Lien (other than a Permitted Lien) superior to the
Lien of Lender on any item of Collateral.

                   (f)    Borrower shall have delivered to Lender a Control
Agreement with respect to each depository and securities account of Borrower, if
such Control Agreement has not previously been delivered to Lender.

                   (g)    Borrower shall have paid the Facility Fee with respect
to the Advance.

                   (h)    Such other documents, and completion of such other
matters, as Lender may reasonably deem necessary or appropriate to evaluate
whether an Event of Default

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has occurred or is continuing and whether there has otherwise been a Material
Adverse Change or to affirm or reinstate Lender's security interest and priority
in the Collateral.

            3.3    COVENANT TO DELIVER. Borrower agrees (not as a condition but
as a covenant) to deliver to Lender each item required to be delivered to Lender
as a condition to each Advance, if such Advance is made. Borrower expressly
agrees that the extension of such Advance prior to the receipt by Lender of any
such item shall not constitute a waiver by Lender of Borrower's obligation to
deliver such item.

     4.     CREATION OF SECURITY INTEREST

            4.1    GRANT OF SECURITY INTEREST. Borrower grants to Lender a
valid, first priority, continuing security interest in all presently existing
and hereafter acquired or arising Collateral, subject only to the Permitted
Liens, in order to secure prompt, full and complete payment of any and all
Obligations and in order to secure prompt, full and complete performance by
Borrower of each of its covenants and duties under each of the Loan Documents.

            4.2    DURATION OF SECURITY INTEREST. Lender's security interest in
the Collateral shall continue until the payment in full and the satisfaction of
all Obligations, whereupon such security interest shall terminate. Lender shall,
at Borrower's sole cost and expense, execute such further documents and take
such further actions as may be necessary to effect the release contemplated by
this SECTION 4.2, including duly executing and delivering termination statements
for filing in all relevant jurisdictions under the Code.

            4.3    POSSESSION OF COLLATERAL. So long as no Event of Default has
occurred and is continuing, Borrower shall remain in full possession, enjoyment
and control of the Collateral (except only as may be otherwise required by
Lender for perfection of its security interest therein) and shall be entitled to
manage, operate and use the same and each part thereof with the rights and
franchises appertaining thereto; PROVIDED, HOWEVER, that the possession,
enjoyment, control and use of the Collateral shall at all times be subject to
the observance and performance of the terms of this Agreement.

            4.4    DELIVERY OF ADDITIONAL DOCUMENTATION REQUIRED. Borrower shall
from time to time execute and deliver to Lender, all financing statements and
other documents such Lender may reasonably request, in form satisfactory to
Lender, to perfect and continue Lender's first priority, perfected security
interests in the Collateral, subject only to Permitted Liens, and in order to
consummate fully all of the transactions contemplated under the Loan Documents.

            4.5    RIGHT TO INSPECT. Lender (through any of its officers,
employees, or agents) shall have the right, upon reasonable prior notice, from
time to time during Borrower's usual business hours, to inspect Borrower's Books
and to make copies thereof and to check, test, and appraise the Collateral in
order to verify Borrower's financial condition or the amount, condition of, or
any other matter relating to, the Collateral.

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     5.     REPRESENTATIONS AND WARRANTIES

     Borrower represents, warrants and covenants as follows:

            5.1    DUE ORGANIZATION AND QUALIFICATION. Borrower is a corporation
duly existing and in good standing under the laws of its state of incorporation
and qualified and licensed to do business in, and is in good standing in, any
state in which the conduct of its business or its ownership of Property requires
that it be so qualified or in which the Collateral is located, except for such
states as to which any failure so to qualify would not have a material adverse
effect on Borrower.

            5.2    AUTHORITY. Borrower has all necessary power and authority to
execute, deliver, and perform in accordance with the terms thereof, the Loan
Documents to which it is a party. Borrower has all requisite power and authority
to own and operate its properties and to carry on its businesses as now
conducted.

            5.3    SUBSIDIARIES. Borrower has no Subsidiaries, except those
listed in SCHEDULE 2 hereto.

            5.4    CONFLICT WITH OTHER INSTRUMENTS, ETC. Neither the execution
and delivery of any Loan Document to which Borrower is a party nor the
consummation of the transactions therein contemplated nor compliance with the
terms, conditions and provisions thereof will conflict with or result in a
breach of any of the terms, conditions or provisions of the articles of
incorporation and the by-laws, or other organizational documents of Borrower or
any law or any regulation, order, writ, injunction or decree of any court or
governmental instrumentality or except to the extent that any contract
identified on SCHEDULE 3 requires any consent or approval, which consent or
approval shall be obtained on or prior to the date hereof, any material
agreement or instrument to which Borrower is a pasty or by which it or any of
its properties is bound or to which it or any of its properties is subject, or
constitute a default thereunder or result in the creation or imposition of any
Lien, other than Permitted Liens.

            5.5    AUTHORIZATION; ENFORCEABILITY. The execution and delivery of
this Agreement, the granting of the security interest in the Collateral, the
incurring of the Advances, the execution and delivery of the other Loan
Documents to which Borrower is a party and the consummation of the transactions
herein and therein contemplated have each been duly authorized by all necessary
action on the part of Borrower. The Loan Documents have been duly executed and
delivered and constitute legal, valid and binding obligations of Borrower,
enforceable in accordance with their respective terms, except as the
enforceability thereof may be limited by bankruptcy, insolvency or other similar
laws of general application relating to or affecting the enforcement of
creditors' rights or by general principles of equity.

            5.6    NO PRIOR ENCUMBRANCES. Except as set forth in SCHEDULE 1,
Borrower has good and marketable title in and to, or an enforceable right to
use, the Collateral, free and clear of liens, claims, security interests, or
encumbrances, except for the first priority lien held by the Lender and except
for other Permitted Liens. Except as disclosed in SCHEDULE 1, Borrower

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has not acquired any part of the Collateral from an assignor outside the
ordinary course of such assignor's business.

            5.7    LOCATION OF CHIEF EXECUTIVE OFFICE, PRINCIPAL PLACE OF
BUSINESS AND COLLATERAL. Borrower has not done business under any name other
than that specified on the signature page hereof. The chief executive office,
principal place of business, and the place where Borrower maintains its records
concerning the Collateral are presently located at the address set forth in
SECTION 11. The Collateral is presently located at the addresses set forth in
SECTION 11.

            5.8    LITIGATION. There are no actions or proceedings pending by or
against Borrower before any court or administrative agency in which an adverse
decision could reasonably be expected to have a material adverse effect on
Borrower or the aggregate value of the Collateral. Borrower does not have
knowledge of any such pending or threatened actions or proceedings. Borrower
will promptly notify Lender in writing if any action, proceeding or governmental
investigation involving Borrower is commenced that may result in damages to
Borrower of One Hundred Thousand Dollars ($100,000) or more.

            5.9    FINANCIAL STATEMENTS. All financial statements relating to
Borrower or any Affiliate that have been delivered, are set forth on SCHEDULE 4,
and may hereafter be required to be delivered by Borrower to Lender present
fairly in all material respects Borrower's financial condition as of the date
thereof and the periods covered thereby and Borrower's results of operations for
the periods then ended.

            5.10   SOLVENCY. Borrower is solvent and able to pay its debts
(including trade debts) as they mature.

            5.11   TAXES. Borrower has filed or caused to be filed all tax
returns required to be filed, and has paid, or has made adequate provision for
the payment of, or has contested in good faith and has adequately reserved
against the payment of, all taxes that are due and payable.

            5.12   CONSENTS AND APPROVALS. No approval, authorization or consent
of any trustee or holder of any indebtedness or obligation of Borrower or of any
other Person under any such material agreement, contract, lease or license or
similar document or instrument to which Borrower is a party or by which Borrower
is bound, is required to be obtained by Borrower in order to make or consummate
the transactions contemplated under the Loan Documents except for such
approvals, authorizations and consents obtained on or prior to the date hereof
required to be so obtained for Borrower's performance of the Loan Documents. All
consents and approvals of, filings and registrations with, and other actions in
respect of, all Governmental Authorities required to be obtained by Borrower in
order to make or consummate the transactions contemplated under the Loan
Documents have been, or prior to the time when required will have been,
obtained, given, filed or taken and are or will be in full force and effect.

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            5.13   TRADEMARKS, PATENTS, COPYRIGHTS, FRANCHISES AND LICENSES.
Borrower possesses and owns or has an enforceable right to use all necessary
trademarks, trade names, copyrights, patents, patent rights, franchises and
licenses which are material to the conduct of its business as now operated.

            5.14   MATERIAL CONTRACTS. All currently effective contracts and
agreements (whether written or oral) to which Borrower is a party are identified
on SCHEDULE 3 hereto. There are no material defaults under any such contract or
agreement by Borrower. Borrower has made available to Lender, as requested by
Lender, true and correct copies of all such contracts or agreements (or, with
respect to oral contracts or agreements, written descriptions of the material
terms thereof).

            5.15   FULL DISCLOSURE. No representation, warranty or other
statement made by Borrower in any Loan Document, certificate or written
statement furnished to Lender contains any untrue statement of a material fact
or omits to state a material fact necessary in order to make the statements
contained in such certificates or statements not misleading in light of the
circumstances in which they were made.

     6.     AFFIRMATIVE COVENANTS

     Borrower covenants and agrees that, until the full and complete payment of
the Obligations and the termination of the Commitments, Borrower shall do all of
the following:

            6.1    GOOD STANDING. Borrower shall maintain its corporate
existence and its good standing in its jurisdiction of incorporation and
maintain qualification in each jurisdiction in which the failure to so qualify
could have a material adverse effect on the financial condition, operations or
business of Borrower. Borrower shall maintain in force all licenses, approvals
and agreements, the loss of which could have a material adverse effect on its
financial condition, operations or business.

            6.2    GOVERNMENT COMPLIANCE. Borrower shall comply with all
statutes, laws, ordinances and government rules and regulations to which it is
subject, noncompliance with which could materially adversely affect the
financial condition, operations or business of Borrower.

            6.3    FINANCIAL STATEMENTS, REPORTS, CERTIFICATES. Borrower shall
deliver to Lender: (a) as soon as available, but in any event within thirty (30)
days after the end of each calendar month, a company prepared balance sheet,
income statement and cash flow statement covering Borrower's operations during
such period, certified by a Responsible Officer, (b) commencing with the 2002
fiscal year, as soon as available, but in any event within one hundred and
twenty (120) days after the end of Borrower's fiscal year, audited financial
statements of Borrower prepared in accordance with generally accepted accounting
principles, consistently applied, together with an unqualified opinion on such
financial statements of a nationally recognized or other independent public
accounting firm reasonably acceptable to

                                       15
<Page>

Lender, PROVIDED, HOWEVER, for the 2002 fiscal year only, Borrower shall provide
such audited financial statements within one hundred and fifty (150) days after
the end of Borrower fiscal year, (c) promptly upon becoming available, copies of
all statements, reports and notices sent or made available generally by Borrower
to its security holders; (d) immediately upon receipt of notice thereof, a
report of any material legal actions pending or threatened in writing against
Borrower, and (e) such other financial information as Lender may reasonably
request from time to time.

            6.4    CERTIFICATES OF COMPLIANCE. Each time financial statements
are furnished pursuant to SECTION 6.3 above, there shall be delivered to Lender
a certificate signed by a Responsible Officer (each an "OFFICER'S CERTIFICATE")
with respect to such financial reports to the effect that: (i) no Event of
Default or Default has occurred and is continuing hereunder since the date of
this Agreement or, if later, since the date of the prior Officer's Certificate
or, if such an event or condition has occurred and is continuing, the nature and
extent thereof and the action Borrower proposes to take with respect thereto,
and (ii) Borrower is in compliance with the provisions of SECTIONS 6 AND 7.

            6.5    NOTICE OF DEFAULTS. As soon as possible, and in any event
within five (5) days after the discovery of a Default or an Event of Default,
provide Lender with an Officer's Certificate of Borrower setting forth the facts
relating to or giving rise to such Default or Event of Default and the action
which Borrower proposes to take with respect thereto.

            6.6    TAXES. Borrower shall make due and timely payment or deposit
of all federal, state, and local taxes, assessments, or contributions required
of it by law or imposed upon any properties belonging to it, and will execute
and deliver to Lender, on demand, appropriate certificates attesting to the
payment or deposit thereof; and Borrower will make timely payment or deposit of
all tax payments and withholding taxes required of it by applicable laws,
including those laws concerning F.I.C.A., F.U.T.A., state disability, and local,
state, and federal income taxes, and will, upon request, furnish Lender with
proof satisfactory to Lender indicating that Borrower has made such payments or
deposits; provided that Borrower need not make any payment if the amount or
validity of such payment is contested in good faith by appropriate proceedings
and is adequately reserved against by Borrower.

            6.7    USE; MAINTENANCE.

                   (a)    Borrower, at its expense, shall cause the Collateral
to be operated in accordance with sound business practices and, if applicable,
with past practices. So long as no Default or Event of Default has occurred and
is continuing, Borrower shall have the right to quietly possess and use the
Collateral as provided herein without interference by Lender.

                   (b)    Borrower, at its expense, shall maintain the
Collateral consistent with sound business practices, and if applicable, past
practices, in good condition, reasonable wear and tear excepted, and will comply
in all material respects with all laws, rules and regulations to which the use
and operation of the Collateral by Borrower may be or become subject. Such
obligation shall extend to repair and replacement of any partial loss or damage
to

                                       16
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the Collateral, regardless of the cause. If maintenance is mandated by
manufacturer, Borrower shall obtain and keep in effect, at all times during the
Term maintenance service contracts with qualified suppliers. All parts furnished
in connection with such maintenance or repair shall immediately become part of
the Collateral. All such maintenance, repair and replacement services shall be
timely paid for and discharged by Borrower with the result that no Lien will
attach to the Collateral.

            6.8    INSURANCE.

                   (a)    Borrower, at its own expense, shall obtain and
maintain in amounts and coverages satisfactory to Lender (a) insurance against
loss or damage to the Collateral, (b) commercial general liability insurance,
including contractual liability, products liability and completed operations
coverage according to standard industry practices, and (c) such other insurance
against such other risks of loss and with such terms as shall be reasonably
satisfactory to or reasonably required by Lender as to carriers, amounts and
otherwise. The amount of insurance covering loss or damage to the Collateral
shall be the greater of (i) the replacement value of the Collateral (as new) or
(ii) the outstanding principal amount of the funds disbursed hereunder and all
other then outstanding amounts payable under the Loan Documents.

                   (b)    The amount of commercial general public liability
insurance (other than products liability coverage and completed operations
insurance) shall be at least $2,000,000 per occurrence. The amount of such
products liability and completed operations insurance shall be at least
$2,000,000 per occurrence. The deductible with respect to insurance against loss
or damage to the Collateral and product liability insurance shall not exceed
$25,000; otherwise there shall be no deductible with respect to any insurance
required to be maintained hereunder without the prior written approval of
Lender. Each such insurance policy shall: (i) name Lender loss payee or
additional insured, as appropriate, (ii) provide for insurer's waiver of its
right of subrogation against Lender and Borrower, (iii) provide that such
insurance shall not be invalidated by any action of, or breach of warranty by,
Borrower and waive set-off counterclaim or offset against Lender, (iv) provide
that Borrower's insurance shall be primary without a right of contribution of
Lender's insurance, if any, or any obligation on the part of Lender to pay
premiums of Borrower, and (v) require the insurer to give Lender at least thirty
(30) days prior written notice of cancellation. Borrower shall, on or prior to
the first disbursement of funds hereunder and prior to each policy renewal,
furnish to Lender certificates of insurance. Borrower shall give Lender prompt
notice of any damage to, or loss of, any Collateral.

            6.9    LOSS; DAMAGE; DESTRUCTION AND SEIZURE.

                   (a)    Borrower shall bear the risk of the Collateral being
lost, stolen, destroyed, damaged beyond repair, rendered permanently unfit for
use, or seized by a governmental authority for any reason whatsoever at any time
until the expiration or termination of the Term.

                                       17
<Page>

                   (b)    So long as no Event of Default has occurred and is
continuing, any proceeds of insurance maintained pursuant to SECTION 6.8
received by Lender or Borrower with respect to an item of Collateral, the repair
of which is practicable, shall, at the election of Borrower, (i) be applied
either to the repair or replacement of such Collateral or, upon Lender's receipt
of evidence of the repair or replacement of the Collateral reasonably
satisfactory to Lender, to the reimbursement of Borrower for the cost of such
repair or replacement, or (ii) with respect to any items of Collateral valued at
Two Hundred Thousand Dollars ($200,000) or less, apply the insurance proceeds to
Borrower's general working capital or (iii) with respect to items of Collateral
valued in excess of Two Hundred Thousand Dollars ($200,000) and with prior
notice to and the consent of Lender, which consent shall not be unreasonably
withheld, apply the insurance proceeds to Borrower's general working capital.
All replacement parts and equipment acquired by Borrower in replacement of
Collateral pursuant to this SECTION 6.9(b) shall immediately become part of the
Collateral upon acquisition by Borrower. Borrower shall take such actions and
provide such documentation as may be reasonably requested by Lender to protect
and preserve its security interest and otherwise to avoid any impairment of
Lender's rights under the Loan Documents in connection with such repair or
replacement.

            6.10   BOARD OBSERVATION AND CONSULTATION RIGHTS.

                   (a)    During the Term, Lender, shall be entitled, upon
execution of a confidentiality agreement mutually acceptable to Lender and
Borrower, to receive (at the same time as other members of Borrower's Board of
Directors) notice of all meetings of the Board of Directors and all materials
disseminated to the Directors, and to have a representative attend all meetings
of the Board of Directors.

                   (b)    Up and until a such time as the Borrower consummates
an initial public offering of its securities and becomes subject to the
reporting requirements of the 1934 Exchange Act, as amended, at such time as
Lender grants a participation to one of its affiliated entities subject to ERISA
requirements, Borrower will execute a Management Rights Letter in the form
attached hereto as Exhibit F.

            6.11   FURTHER ASSURANCES. At any time and from time to time
Borrower shall execute and deliver such further instruments and take such
further action as may reasonably be requested by Lender to effect the purposes
of this Agreement.

            6.12   EQUITY PARTICIPATION RIGHT. Borrower shall use reasonable
best efforts to grant Lender, exercisable at Lender's sole discretion, the
option to purchase for cash up to $250,000.00 of preferred stock in Borrower's
next round of venture capital preferred stock financing which is not a Strategic
Round (as defined below) upon the same terms and conditions as all other
financial investors investing up to $250,000.00 at the same time. Borrower shall
provide Lender at least seven (7) days' prior written notice of the proposed
closing date of such preferred stock financing together with available drafts of
the investment documents for such financing in such state as the drafts may be
at the time the notice is provided. Following Borrower's receipt of a written
indication from Lender that Lender is interested in participating in the
financing, Borrower shall circulate to Lender subsequent drafts of investment
documents

                                       18
<Page>

generally provided to all other potential investors in the financing. For
purposes hereof, a "Strategic Round" shall mean the issuance and sale of
preferred stock of the Borrower in which one or more "strategic investors" is
purchasing more than fifty percent (50%) of the preferred stock issued and sold
in such transaction, which purchase is made by the "strategic investor" in
connection with a separate transaction between an Affiliate of such investor and
Borrower, including, for example, a licensing, development, sale or joint
venture agreement.

     7.     NEGATIVE COVENANTS

     Borrower covenants and agrees that until the full and complete payment of
the Obligations and termination of the Commitments, Borrower will not do any of
the following:

            7.1    CHIEF EXECUTIVE OFFICE; LOCATION OF COLLATERAL. During the
continuance of this Agreement, change the state of incorporation, chief
executive office or principal place of business or remove or cause to be
removed, except in the ordinary course of Borrower's business, the Collateral or
the records concerning the Collateral from the premises listed in SECTION 11
without thirty (30), days prior written notice to Lender.

            7.2    EXTRAORDINARY TRANSACTIONS AND DISPOSAL OF ASSETS. Enter into
any transaction not in the ordinary and usual course of Borrower's business,
including the sale, lease, license or other disposition of, moving, relocation,
or transfer, whether by sale or otherwise, of Borrower's assets, other than (i)
sales of inventory in the ordinary and usual course of Borrower's business as
presently conducted and (ii) sales or other dispositions in the ordinary course
of business of assets that have become worn out or obsolete or that are promptly
being replaced.

Notwithstanding anything contained in this SECTION 7.2, the Borrower may do any
of the following: (i) transfer licenses and similar arrangements for use of its
intellectual property, or enter into joint venture and co-development
arrangements, in each case in the ordinary course of its business for adequate
consideration, which transactions are consistent with the conduct of Borrower's
business as now conducted or proposed to be conducted (it being acknowledged
that joint ventures and co-development arrangements are in the ordinary course
of Borrower's business) (ii) declare and make any dividend payment payable in
its equity securities, (iii) convert any of its convertible securities into
other securities pursuant to the terms of such convertible securities or
otherwise in exchange therefor, (iv) repurchase stock from former employees of
Borrower in accordance with the terms of repurchase, vesting or similar
agreements between Borrower and such employees in its ordinary course of
business, (v) repurchase equity securities with the proceeds from the issuance
of equity securities, (vi) repurchase, redeem, retire, defease or otherwise
acquire for value equity securities in connection with or pursuant to any
employees benefit plan or stock option plan of the Borrower; (vii) provided no
Event of Default has occurred and is continuing or is not caused thereby,
mergers, consolidations or acquisitions, which after giving effect thereto,
Borrower is the surviving entity, and (viii) enter into Permitted Investments.

                                       19
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            7.3    RESTRUCTURE. Change Borrower's name; make any material change
in Borrower's financial structure or business operations (other than through the
sale of stock to equity investors or in Permitted Investments); cause, permit,
or suffer any material change in Borrower's ownership other than in connection
with the sale of stock to equity investors, or suspend operation of Borrower's
business.

            7.4    LIENS. Create, incur, assume or suffer to exist any Lien or
any other encumbrance of any kind with respect to any of its Property, whether
now owned or hereafter acquired, except for Permitted Liens.

            7.5    INDEBTEDNESS. Create, incur, assume or suffer to exist any
Indebtedness other than Permitted Indebtedness.

            7.6    INVESTMENTS. Make any Investment in any Person, other than
Permitted Investments; and other than as permitted under SECTION 7.2(1), or
permit any Subsidiary to do so.

            7.7    DISTRIBUTIONS. Except as permitted by SECTION 7.2, pay any
dividends or make any distribution or payment or redeem, retire or purchase any
capital stock, except for the repurchase of stock in accordance with the
existing terms of Borrower's stock option and incentive plans, which terms have
been approved by the Board of Directors of the Borrower.

            7.8    TRANSACTIONS WITH AFFILIATES. Directly or indirectly enter
into or permit to exist any material transaction with any Affiliate of Borrower
except for transactions that are (i) in the ordinary course of Borrower's
business, on terms no less favorable to Borrower than would be obtained in an
arm's length transaction with a non-affiliated Person or (ii) are approved by a
majority of the disinterested members of the Borrower's Board of Directors or a
committee thereof.

            7.9    COMPLIANCE. Become an "investment company" under the
Investment Company Act of 1940 or undertake as one of its important activities
extending credit to purchase or carry margin stock, or use the proceeds of any
Credit Extension for that purpose; fail to meet the minimum funding requirements
of ERISA, permit a Reportable Event or Prohibited Transaction, as defined in
ERISA, to occur; fail to comply with the Federal Fair Labor Standards Act or
violate any other law or regulation, if the violation could reasonably be
expected to have a material adverse effect on Borrower's business or operations
or would reasonably be expected to cause a Material Adverse Change, or permit
any of its Subsidiaries to do so.

     8.     EVENTS OF DEFAULT

     Any one or more of the following events shall constitute an Event of
Default by Borrower under this Agreement:

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<Page>

            8.1    PAYMENT DEFAULT. If Borrower fails to pay when due and
payable or when declared due and payable in accordance with the Loan Documents,
any portion of the Obligations and Borrower has failed to cure such Default
within three (3) days.

            8.2    CERTAIN COVENANT DEFAULTS. If Borrower fails to perform any
obligation under SECTIONS 6.8, 6.9, or 6.10, or violates any of the covenants
contained in SECTION 7 of this Agreement and Borrower has failed to cure such
Default within five (5) Business Days.

            8.3    OTHER COVENANT DEFAULT. If Borrower fails or neglects to
perform, keep, or observe any other material term, provision, condition,
covenant, or agreement contained in this Agreement, in any of the other Loan
Documents, or in any other present or future agreement between Borrower and
Lender and as to any default under such other term, provision, condition,
covenant or agreement that can be cured, has failed to cure such default within
thirty (30) days after the occurrence of such default.

            8.4    MATERIAL ADVERSE CHANGE. If there occurs a Material Adverse
Change; provided however, that any time following the termination of the
Commitment Termination Date, Borrower shall be permitted not more than fifteen
(15) days after Borrower learns of or knows of the Material Adverse Change to
cure such Material Adverse Change to the reasonable satisfaction of Lender.

            8.5    ATTACHMENT. If any material portion of Borrower's assets is
attached, seized, subjected to a writ or distress warrant, or is levied upon, or
comes into the possession of any trustee, receiver or Person acting in a similar
capacity and such attachment, seizure, writ or distress warrant or levy has not
been removed, discharged or rescinded within ten (10) days, or if Borrower is
enjoined, restrained, or in any way prevented by court order from continuing to
conduct all or any material part of its business affairs, or if a judgment or
other claim becomes a lien or encumbrance upon any material portion of
Borrower's assets, or if a notice of lien, levy, or assessment is filed of
record with respect to any of Borrower's assets by the United States Government,
or any department, agency, or instrumentality thereof, or by any state, county,
municipal, or governmental agency, and the same is not paid within ten (10) days
after Borrower receives notice thereof, PROVIDED that none of the foregoing
shall constitute an Event of Default where such action or event is stayed or an
adequate bond has been posted pending a good faith contesting by Borrower.

            8.6    OTHER AGREEMENTS. If there is a default in any agreement to
which Borrower is a party with a third party or parties resulting in a right by
such third party or parties, whether or not exercised, to accelerate the
maturity of any Indebtedness in excess of Two Hundred Fifty Thousand Dollars
($250,000).

            8.7    JUDGMENTS. If a judgment or judgments for the payment of
money in an amount, individually or in the aggregate, of at least Two Hundred
Fifty Thousand Dollars ($250,000) shall be rendered against Borrower and shall
remain unsatisfied and unstayed for a period of thirty(30) days.

                                       21
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            8.8    REDEMPTION OR REPURCHASE. Borrower shall, after the date of
this Agreement, redeem or repurchase (a) any shares of any class or series of
its preferred stock or (b) more than Fifty Thousand Dollars ($50,000) in the
aggregate of common stock, in each case whether pursuant to a mandatory
redemption or otherwise.

            8.9    MISREPRESENTATIONS. If any material misrepresentation or
material misstatement exists now or hereafter in any warranty, representation,
statement, or report made to Lender by Borrower or any officer, employee, agent,
or director of Borrower; provided that at any time subsequent to the Commitment
Date, Borrower shall be permitted thirty (30) days to cure such Default.

            8.10   ENFORCEABILITY. If any Loan Document shall in any material
respect cease to be, or Borrower shall assert that any Loan Document is not, a
legal, valid and binding obligation of Borrower enforceable in accordance with
its terms.

            8.11   INVOLUNTARY BANKRUPTCY OR INSOLVENCY. If a proceeding shall
have been instituted in a court having jurisdiction in the premises seeking a
decree or order for relief in respect of Borrower in an involuntary case under
any applicable bankruptcy, insolvency or other similar law now or hereafter in
effect, or for the appointment of a receiver, liquidator, assignee, custodian,
trustee (or similar official) of Borrower or for any substantial part of its
property, or for the winding-up or liquidation of its affairs, and such
proceeding shall remain undismissed or unstayed and in effect for a period of
sixty (60) consecutive days or such court shall enter a decree or order granting
the relief sought in such proceeding.

            8.12   VOLUNTARY BANKRUPTCY OR INSOLVENCY. If Borrower shall
commence a voluntary case under any applicable bankruptcy, insolvency or other
similar law now or hereafter in effect, shall consent to the entry of an order
for relief in an involuntary case under any such law, or shall consent to the
appointment of or taking possession by a receiver, liquidator, assignee,
trustee, custodian (or other similar official) of Borrower or for any
substantial part of its property, or shall make a general assignment for the
benefit of creditors, or shall fail generally to pay its debts as they become
due, or shall take any corporate action in furtherance of any of the foregoing.

     9.     LENDER'S RIGHTS AND REMEDIES

            9.1    RIGHTS AND REMEDIES. Upon the occurrence and continuance of
any Event of Default, Lender shall have no further obligation to advance money
or extend credit to or for the benefit of Borrower. In addition, upon the
occurrence and during the continuance of an Event of Default, Lender shall have
the rights, options, duties and remedies of a secured party as permitted by law
and, in addition to and without limitation of the foregoing, Lender may, at its
election, without notice of election and without demand, do any one or more of
the following, all of which are authorized by Borrower:

                                       22
<Page>

                   (a)    Declare all Obligations, whether evidenced by this
Agreement, by any of the other Loan Documents, or otherwise, including the
outstanding principal amount of, and accrued interest on, each Advance,
immediately due and payable (PROVIDED that upon the occurrence of an Event of
Default described in SECTION 8.11 or 8.12 all Obligations shall become
immediately due and payable without any action by Lender);

                   (b)    Without notice to or demand upon Borrower, make such
payments and do such acts as Lender consider necessary or reasonable to protect
its security interest in the Collateral. Borrower agrees to assemble the
Collateral if Lender so requires, and to make the Collateral available to Lender
as Lender may designate. Borrower authorizes Lender to enter the premises where
the Collateral is located, to take and maintain possession of the Collateral, or
any part of it, and to pay, purchase, contest, or compromise any encumbrance,
charge, or lien which in Lender's determination appears to be prior or superior
to its security interest and to pay all expenses incurred in connection
therewith. With respect to any of Borrower's owned premises, Borrower hereby
grants Lender a license to enter into possession of such premises and to occupy
the same, without charge, for up to one hundred twenty (120) days in order to
exercise any of Lender's rights or remedies provided herein, at law, in equity,
or otherwise;

                   (c)    Without prior notice to Borrower (provided that notice
is provided to Borrower within a commercially reasonable time thereafter), set
off and apply to the Obligations any and all indebtedness at any time owing to
or for the credit or the account of Borrower;

                   (d)    Ship, reclaim, recover, store, finish, maintain,
repair, prepare for sale, advertise for sale, and sell (in the manner provided
for herein) the Collateral. Lender is hereby granted a license or other right,
solely to enable Lender to exercise its rights and remedies pursuant to and in
accordance with the provisions of this SECTION 9.1, to use, without charge,
Borrower's labels, patents, copyrights, rights of use of any name, trade
secrets, trade names, trademarks, service marks, and advertising matter, or any
Property of a similar nature, as it pertains to the Collateral, in completing
production of, advertising for sale, and selling any Collateral and, in
connection with Lender's exercise of its rights under this SECTION 9.1,
Borrower's rights under all licenses and all franchise agreements shall inure to
Lender's benefit;

                   (e)    Sell the Collateral at either a public or private
sale, or both, by way of one or more contracts or transactions, for cash or on
terms, in such manner and at such places (including Borrower's premises) as
Lender determines are commercially reasonable;

                   (f)    Lender may credit bid and purchase at any public sale;
and

                   (g)    Any deficiency that exists after disposition of the
Collateral as provided above will be paid immediately by Borrower.

            9.2    WAIVER BY BORROWER. Upon the occurrence of an Event of
Default, to the extent permitted by law, Borrower covenants that it will not at
any time insist upon or plead, or

                                       23
<Page>

in any manner whatever claim or take any benefit or advantage of, any stay or
extension of law now or at any time hereafter in force, nor claim, take nor
insist upon any benefit or advantage of or from any law now or hereafter in
force providing for the valuation or appraisement of the Collateral or any part
thereof prior to any sale or sales thereof to be made pursuant to any provision
herein contained, or to the decree, judgment or order of any court of competent
jurisdiction; nor, after such sale or sales, claim or exercise any right under
any statute now or hereafter made or enacted by any state or otherwise to redeem
the Property so sold or any part thereof.

            9.3    EFFECT OF SALE. Any sale, whether under any power of sale
hereby given or by virtue of judicial proceedings, shall operate to divest all
right, title, interest, claim and demand whatsoever, either at law or in equity,
of Borrower in and to the Property sold, and shall be a perpetual bar, both at
law and in equity, against Borrower, its successors and assigns, and against any
and all Persons claiming the Property sold or any part thereof under, by or
through Borrower, its successors or assigns.

            9.4    POWER OF ATTORNEY IN RESPECT OF THE COLLATERAL. Borrower does
hereby irrevocably appoint Lender (which appointment is coupled with an
interest) on the occurrence and during the continuance of an Event of Default,
the true and lawful attorney in fact of Borrower with full power of
substitution, for it and in its name: (a) to ask, demand, collect, receive,
receipt for, sue for, compound and give acquittance for any and all rents,
issues, profits, avails, distributions, income, payment draws and other sums in
which a security interest is granted under SECTION 4 with full power to settle,
adjust or compromise any claim thereunder as fully as if Lender were a Borrower
itself, (b) to receive payment of and to endorse the name of Borrower to any
items of Collateral (including checks, drafts and other orders for the payment
of money) that come into Lender's possession or under Lender's control, (c) to
make all demands, consents and waivers, or take any other action with respect
to, the Collateral, (d) in Lender's discretion to file any claim or take any
other action or proceedings, either in its own name or in the name of Borrower
or otherwise, which Lender may reasonably deem necessary or appropriate to
protect and preserve the right, title and interest of Lender in and to the
Collateral, or (e) to otherwise act with respect thereto as though Lender were
the outright owner of the Collateral.

            9.5    LENDER'S EXPENSES. If Borrower fails to pay any amounts or
furnish any required proof of payment due to third persons or entities, as
required under the terms of this Agreement, then Lender may do any or all of the
following: (a) make payment of the same or any part thereof; (b) set up such
reserves in Borrower's loan account as Lender deems necessary to protect Lender
from the exposure created by such failure; or (c) obtain and maintain insurance
policies of the type discussed in SECTION 6.8 of this Agreement, and take any
action with respect to such policies as Lender reasonably deems prudent. Any
amounts paid or deposited by Lender shall constitute Lender's Expenses, shall be
immediately due and payable, and shall bear interest at the then applicable rate
hereinabove provided, and shall be secured by the Collateral. Any payments made
by Lender shall not constitute an agreement by Lender to make Similar payments
in the future or a waiver by Lender of any Event of Default under this
Agreement.

                                       24
<Page>

            9.6    REMEDIES CUMULATIVE. Lender's rights and remedies under this
Agreement, the Loan Documents, and all other agreements shall be cumulative.
Lender shall have all other rights and remedies not inconsistent herewith as
provided under the Code, by law, or in equity. No exercise by Lender of one
right or remedy shall be deemed an election, and no waiver by Lender of any
Event of Default on Borrower's part shall be deemed a continuing waiver. No
delay by Lender shall constitute a waiver, election, or acquiescence by it.

            9.7    APPLICATION OF COLLATERAL PROCEEDS. The proceeds and/or
avails of the Collateral, or any part thereof, and the proceeds and the avails
of any remedy hereunder (as well as any other amounts of any kind held by Lender
at the time off or received by Lender after, the occurrence of an Event of
Default hereunder) shall be paid to and applied as follows:

                   (a)    FIRST, to the payment of out-of-pocket costs and
expenses, including all amounts expended to preserve the value of the
Collateral, of foreclosure or suit, if any, and of such sale and the exercise of
any other rights or remedies, and of all proper fees, expenses, liability and
advances, including reasonable legal expenses and attorneys' fees, incurred or
made hereunder by Lender,

                   (b)    SECOND, to the payment to Lender of the amount then
owing or unpaid on the Advances for Scheduled Payments, the unpaid principal
amount of the Advances, and all other Obligations with respect to all Advances,
and in case such proceeds shall be insufficient to pay in full the whole amount
so due, owing or unpaid upon the Advances, then to the unpaid interest thereon,
then to the unpaid principal amount of the Advances, and then to the payment of
other amounts then payable to Lender under any of the Loan Documents; and

                   (c)    THIRD to the payment of the surplus, if any, to
Borrower, its successors and assigns, or to whomsoever may be lawfully entitled
to receive the same.

            9.8    REINSTATEMENT OF RIGHTS. If Lender shall have proceeded to
enforce any right under this Agreement or any other Loan Document by
foreclosure, sale, entry or otherwise, and such proceedings shall have been
discontinued or abandoned for any reason or shall have been determined
adversely, then and in every such case (unless otherwise ordered by a court of
competent jurisdiction), Lender shall be restored to its former position and
rights hereunder with respect to the Property subject to the security interest
created under this Agreement.

     10.    WAIVERS; INDEMNIFICATION

            10.1   DEMAND; PROTEST. Except as otherwise reserved by Borrower in
the Loan Documents, Borrower waives demand, protest, notice of protest, notice
of default or dishonor, notice of payment and nonpayment, notice of any default,
nonpayment at maturity, release, compromise, settlement, extension, or renewal
of accounts, documents, instruments, chattel paper, and guarantees at any time
held by Lender on which Borrower may in any way be liable.

                                       25
<Page>

            10.2   LENDER'S LIABILITY FOR COLLATERAL. So long as Lender complies
with its obligations, if any, under Section 9-207 of the Code, Lender shall not
in any way or manner be liable or responsible for: (a) the safekeeping of the
Collateral; (b) any loss or damage thereto occurring or arising in any manner or
fashion from any cause; (c) any diminution in the value thereof, or (d) any act
or default of any carrier, warehouseman, bailee, forwarding agency, or other
Person whomsoever. All risk of loss, damage or destruction of the Collateral
shall be borne by Borrower.

            10.3   INDEMNIFICATION. Whether or not the transactions contemplated
hereby shall be consummated:

                   (a)    GENERAL INDEMNITY. Borrower shall pay, indemnify, and
hold bender and each of its officers, directors, employees, counsel, partners,
agents and attorneys-in-fact (each, an "INDEMNIFIED PERSON") harmless from and
against any and all liabilities, obligations, losses, damages, penalties,
actions, judgments, suits, costs, charges, expenses or disbursements (including
Lender's Expenses and reasonable attorney's fees) of any kind or nature
whatsoever with respect to the execution, delivery, enforcement, performance and
administration of this Agreement and any other Loan Documents, or the
transactions contemplated hereby and thereby, and with respect to any
investigation, litigation or proceeding (including any case, action or
proceeding before any court or other Governmental Authority relating to
bankruptcy, reorganization, insolvency, liquidation, dissolution or relief of
debtors or any appellate proceeding) related to this Agreement or the Advances
or the use of the proceeds thereof; whether or not any Indemnified Person is a
party thereto (all the foregoing collectively, the "INDEMNIFIED LIABILITIES");
PROVIDED, that Borrower shall have no obligation hereunder to any Indemnified
Person with respect to Indemnified Liabilities arising from the gross negligence
or willful misconduct of such Indemnified Person.

                   (b)    SURVIVAL; DEFENSE. The obligations in this SECTION
10.3 shall survive payment of all other Obligations. At the election of any
Indemnified Person, Borrower shall defend such Indemnified Person using legal
counsel satisfactory to such Indemnified Person in such Person's sole
discretion, at the sole cost and expense of Borrower. All amounts owing under
this SECTION 10.3 shall be paid within thirty (30) days after written demand.

     11.    NOTICES

     Unless otherwise provided in this Agreement, all notices or demands by any
party relating to this Agreement or any other agreement entered into in
connection herewith shall be in writing and (except for financial statements and
other informational documents which may be sent by first-class mail, postage
prepaid) shall be personally delivered or sent by certified mail, postage
prepaid, return receipt requested, or by prepaid facsimile to Borrower or to
Lender, as the case may be, at their respective addresses set forth below:

  If to Borrower:         NeuroMetrix, Inc.
                          62 Fourth Avenue
                          Waltham, MA 02451

                                       26
<Page>

                          Attention: Chief Financial Officer
                          FAX: 781-980-1556

  With a copy to:         Goodwin Procter LLP
                          53 State Street
                          Boston, MA 02109
                          Attention  H. David Henken, P.C.
                          Fax: 617-523-1231

  If to Lender:           Lighthouse Capital Partners IV, LP
                          500 Drake's Landing Road
                          Greenbrae, California  94904-3011
                          Attention: Contract Administrator
                          FAX: (415) 925-3387

     The parties hereto may change the address at which they are to receive
notices hereunder, by notice in writing in the foregoing manner given to the
other.

     12.    GENERAL PROVISIONS

            12.1   SUCCESSORS AND ASSIGNS. This Agreement shall bind and inure
to the benefit of the respective successors and permitted assigns of each of the
parties; PROVIDED, HOWEVER, that neither this Agreement nor any rights hereunder
may be assigned by Borrower without Lender's prior written consent, which
consent may be granted or withheld in Lender's sole discretion. Lender shall
have the right without the consent of Borrower at any time after the Commitment
Termination Date to sell, transfer, negotiate, or grant participations (a
"Lender Assignment") in all or any part of, or any interest in such Lender's
rights and benefits hereunder to a Person that is not a competitor of the
Borrower and who has executed a confidentiality agreement with Borrower
reasonably acceptable to Borrower; provided that Lender will provide Borrower
with not less than thirty (30) days prior notice of the proposed Lender
Assignment.

            12.2   TIME OF ESSENCE. Time is of the essence for the performance
of all obligations set forth in this Agreement.

            12.3   SEVERABILITY OF PROVISIONS. Each provision of this Agreement
shall be severable from every other provision of this Agreement for the purpose
of determining the legal enforceability of any specific provision.

            12.4   ENTIRE AGREEMENT; CONSTRUCTION; AMENDMENTS AND WAIVERS.

                   (a)    This Agreement and each of the other Loan Documents
dated as of the date hereof taken together, constitute and contain the entire
agreement between Borrower and Lender and supersede any and all prior
agreements, negotiations, correspondence,

                                       27
<Page>

understandings and communications between the parties, whether written or oral,
respecting the subject matter hereof.

                   (b)    This Agreement is the result of negotiations between
and has been reviewed by each of Borrower and Lender executing this Agreement as
of the date hereof and their respective counsel; ACCORDINGLY, this Agreement
shall be deemed to be the product of the parties hereto, and no ambiguity shall
be construed in favor of or against Borrower or Lender.

                   (c)    Any and all amendments, modifications, discharges or
waivers of, or consents to any departures from any provision of this Agreement
or of any of the other Loan Documents shall not be effective without the written
consent of Lender. Any waiver or consent with respect to any provision of the
Loan Documents shall be effective only in the specific instance and for the
specific purpose for which it was given. No notice to or demand on Borrower in
any case shall entitle Borrower to any other or further notice or demand in
similar or other circumstances. Any amendment, modification, waiver or consent
effected in accordance with this SECTION 12.4 shall be binding upon Lender and
on Borrower.

            12.5   RELIANCE BY LENDER. All covenants, agreements,
representations and warranties made herein by Borrower shall, notwithstanding
any investigation by Lender, be deemed to be material to and to have been relied
upon by Lender.

            12.6   NO SET-OFFS BY BORROWER. All sums payable by Borrower
pursuant to this Agreement or any of the other Loan Documents shall be payable
without notice or demand and shall be payable in United States Dollars without
set-off or reduction of any manner whatsoever.

            12.7   COUNTERPARTS. This Agreement may be executed in any number of
counterparts and by different parties on separate counterparts, each of which,
when executed and delivered, shall be deemed to be an original, and all of
which, when taken together, shall constitute but one and the same Agreement.

            12.8   SURVIVAL. All covenants, representations and warranties made
in this Agreement shall continue in full force and effect so long as any
Obligations remain outstanding. The obligations of Borrower to indemnify Lender
with respect to the expenses, damages, losses, costs and liabilities described
in SECTION 10.3 shall survive until all applicable statute of limitations
periods with respect to actions that may be brought against Lender have run.

     13.    TAX REPORTING. Borrower and Lender hereby acknowledge and agree that
(i) the Warrant to purchase stock is part of an investment unit within the
meaning of Section 1273(c)(2) of the Internal Revenue Code and that pursuant to
Treas. Reg. Section 1.1273-2(h), US$100.00 of the issue price of the investment
unit will be allocable to the Warrant and the balance shall be allocable to the
Loans and (ii) each agrees to prepare their respective federal income tax
returns in a manner consistent with the foregoing agreement.

                                       28
<Page>

     14.    RELATIONSHIP OF PARTIES. Borrower and Lender acknowledge, understand
and agree that the relationship between the Borrower, on the one hand, and
Lender, on the other, is, and at all times shall remain solely that of a
borrower and lender. Lender shall not under any circumstances be construed to be
a partner or joint venturer of Borrower or any of its Affiliates; nor shall the
Lender under any circumstances be deemed to be in a relationship of confidence
or trust or a fiduciary relationship with Borrower or any of its Affiliates, or
to owe any fiduciary duty to Borrower or any of its Affiliates. Lender does not
undertake or assume any responsibility or duty to Borrower or any of its
Affiliates to select, review, inspect, supervise, pass judgment upon or
otherwise inform the Borrower or any of its Affiliates of any matter in
connection with its or their Property, any Collateral held by Lender or the
operations of Borrower or any of its Affiliates. Borrower and each of its
Affiliates shall rely entirely on their own judgment with respect to such
matters, and any review, inspection, supervision, exercise of judgment or supply
of information undertaken or assumed by Lender in connection with such matters
is solely for the protection of Lender and neither Borrower nor any Affiliate is
entitled to rely thereon.

     15.    CHOICE OF LAW AND VENUE; JURY TRIAL WAIVER. THIS AGREEMENT SHALL BE
GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE INTERNAL LAWS OF THE STATE OF
CALIFORNIA, WITHOUT REGARD TO PRINCIPLES OF CONFLICTS OF LAW. EACH OF BORROWER
AND LENDER HEREBY SUBMITS TO THE EXCLUSIVE JURISDICTION OF THE STATE AND FEDERAL
COURTS LOCATED IN THE COUNTY OF SANTA CLARA, STATE OF CALIFORNIA. BORROWER AND
LENDER HEREBY WAIVE THEIR RESPECTIVE RIGHTS TO A JURY TRIAL OF ANY CLAIM OR
CAUSE OF ACTION BASED UPON OR ARISING OUT OF ANY OF THE LOAN DOCUMENTS OR ANY OF
THE TRANSACTIONS CONTEMPLATED THEREIN, INCLUDING CONTRACT CLAIMS, TORT CLAIMS,
BREACH OF DUTY CLAIMS, AND ALL OTHER COMMON LAW OR STATUTORY CLAIMS.

                                       29
<Page>

     IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be
executed as of the date first above written.

BORROWER:                          LENDER:

NEUROMETRIX, INC.                  LIGHTHOUSE CAPITAL PARTNERS IV, L.P.

                                   By:  LIGHTHOUSE MANAGEMENT
By:/s/ Shai Gozani                      PARTNERS IV, L.L.C., ITS GENERAL PARTNER
   ---------------

Name: Shai Gozani                  By:/s/ Dennis Ryan
                                      ---------------

Title: President and CEO           Name: Dennis Ryan

                                   Title: Chief Operating Officer

Exhibit A-1   -   Collateral Description
Exhibit A-2   -   Control Agreement
Exhibit B     -   Form of Preferred Stock Warrant
Exhibit C     -   Form of Notice of Borrowing
Exhibit D     -   Form of Intellectual Property Security Agreement
Exhibit E     -   Form of Ancillary Documents
Exhibit F     -   Management Rights Letter
DISCLOSURE SCHEDULES:
Schedule 1    -   Existing Liens
Schedule 2    -   Subsidiaries
Schedule 3    -   Permitted Investments and Permitted Indebtedness
Schedule 4    -   Financial Statements
Schedule 5    -   Schedule of Material Contracts
Schedule 6    -   Indebtedness

                                       30<Page>

                                                                   EXHIBIT 10.15

THIS WARRANT HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS
AMENDED (THE "1933 ACT"), OR ANY APPLICABLE STATE SECURITIES LAWS, AND. MAY NOT
BE SOLD OR TRANSFERRED UNLESS SUCH SALE OR TRANSFER IS IN ACCORDANCE WITH THE
REGISTRATION REQUIREMENTS OF SUCH ACT AND APPLICABLE LAWS OR SOME OTHER
EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF SUCH ACT AND APPLICABLE LAWS IS
AVAILABLE WITH RESPECT THERETO.

                        PREFERRED STOCK PURCHASE WARRANT

Warrant No. W-1                                        Number of Shares: 400,000
                                   Series E-1 Voting Convertible Preferred Stock
                                                         (subject to adjustment)

                                NEUROMETRIX, INC.

                          Effective as of May 21, 2003

                             Void after May 21, 2010

     1.     ISSUANCE. This Preferred Stock Purchase Warrant (the "WARRANT") is
issued to LIGHTHOUSE CAPITAL PARTNERS IV, L.P. by NEUROMETRIX INC, a Delaware
corporation (hereinafter with its successors called the "COMPANY").

     2.     PURCHASE PRICE; NUMBER OF SHARES.

            (a)    The registered holder of this Warrant (the "HOLDER"),
commencing on the date hereof, is entitled upon surrender of this Warrant with
the subscription form annexed hereto duly executed, at the principal office of
the Company, to purchase from the Company, at a price per share of $1.50 (the
"PURCHASE PRICE"), 400,000 fully paid and nonassessable shares of the Company's
Series E-1 Voting Convertible Preferred Stock, $0.001 par value (the "Preferred
Stock").

            (b)    On December 31, 2003, the number of shares of Preferred Stock
issuable upon the exercise of this Warrant (the "EXERCISE QUANTITY") shall
automatically and without further action on the part of the Company or the
Holder be reduced to 333,333 shares in the event Company has drawn $2,000,000 or
less of the Commitment Amount under the Loan Agreement.

     In addition to other terms which may be defined herein, the following
terms, as used in this Warrant, shall have the following meanings:

                   (i)    "Commitment Amount " means $3,000,000.00.

<Page>

                   (ii)   "Loan Agreement" means that certain Loan and Security
     Agreement No. 3561 dated May 21, 2003 between the Company and Lighthouse
     Capital Partners IV, L.P..

     Any term not defined herein shall have the meaning as set forth in the Loan
     Agreement.

     Until such time as this Warrant is exercised in full or expires, the
Purchase Price and the securities issuable upon exercise of this Warrant are
subject to adjustment as hereinafter provided. The person or persons in whose
name or names any certificate representing shares of Preferred Stock is issued
hereunder shall be deemed to have become the holder of record of the shares
represented thereby as at the close of business on the date this Warrant is
exercised with respect to such shares, whether or not the transfer books of the
Company shall be closed.

     3.     PAYMENT OF PURCHASE PRICE. The Purchase Price may be paid (i) in
cash or by check, (ii) by the surrender by the Holder to the Company of any
promissory notes or other obligations issued by the Company, with all such notes
and obligations so surrendered being credited against the Purchase Price in an
amount equal to the principal amount thereof plus accrued interest to the date
of surrender, or (iii) by any combination of the foregoing.

     4.     NET ISSUE ELECTION. The Holder may elect to receive, without the
payment by the Holder of any additional consideration, shares of Preferred Stock
equal to the value of this Warrant or any portion hereof by the surrender of
this Warrant or such portion to the Company, with the net issue election notice
annexed hereto duly executed, at the principal office of the Company. Thereupon,
the Company shall issue to the Holder such number of fully paid and
nonassessable shares of Preferred Stock as is computed using the following
formula:

                                   X - Y(A-B)
                                       ------
                                         A

     where:    X  =  the number of shares of Preferred Stock to be issued to the
                     Holder pursuant to this SECTION 4.

               Y  =  the number of shares of Preferred Stock covered by this
                     Warrant in respect of which the net issue election is made
                     pursuant to this SECTION 4.

               A  =  the Fair Market Value (defined below) of one share of
                     Preferred Stock, as determined at the time the net issue
                     election is made pursuant to this SECTION 4.

               B  =  the Purchase Price in effect under this Warrant at the time
                     the net issue election is made pursuant to this SECTION 4.

     "FAIR MARKET VALUE" of a share of Preferred Stock (or fully paid and
nonassessable shares of the Company's common stock, $0.0001 par value (the
"COMMON STOCK") if the Preferred Stock has been automatically converted into
Common Stock) as of the date that the net issue election is made (the
"DETERMINATION DATE") shall mean:

                                        2
<Page>

                   (i)    If the net issue election is made in connection with
     and contingent upon the closing of the sale of the Company's Common Stock
     to the public in a public offering pursuant to a Registration Statement
     under the 1933 Act (a "PUBLIC OFFERING"), and if the Company's Registration
     Statement relating to such Public Offering ("REGISTRATION STATEMENT") has
     been declared effective by the Securities and Exchange Commission, then the
     initial "Price to Public" specified in the final prospectus with respect to
     such offering multiplied by the number of shares of Common Stock into which
     each share of Preferred Stock is then convertible.

                   (ii)   If the net issue election is not made in connection
     with and contingent upon a Public Offering, then as follows:

                          (A)   If traded on a securities exchange or the Nasdaq
            National Market, the fair market value of the Common Stock shall be
            deemed to be the average of the closing or last reported sale prices
            of the Common Stock on such exchange or market over the five day
            period ending five trading days prior to the Determination Date, and
            the fair market value of the Preferred Stock shall be deemed to be
            such fair market value of the Common Stock multiplied by the number
            of shares of Common Stock into which each share of Preferred Stock
            is then convertible;

                          (B)   If otherwise traded in an over-the-counter
            market, the fair market value of the Common Stock shall be deemed to
            be the average of the closing ask prices of the Common Stock over
            the five day period ending five trading days prior to the
            Determinations Date, and the fair market value of the Preferred
            Stock shall be deemed to be such fair market value of the Common
            Stock multiplied by the number of shares of Common Stock into which
            each share of Preferred Stock is then convertible; and

                          (C)   If there is no public market for the Common
            Stock, then fair market value shall be determined in good faith by
            the Company's Board of Directors.

     5.     PARTIAL EXERCISE. This Warrant may be exercised in part, and the
Holder shall be entitled to receive a new warrant, which shall be dated as of
the date of this Warrant, covering the number of shares in respect of which this
Warrant shall not have been exercised.

     6.     FRACTIONAL SHARES. In no event shall any fractional share of
Preferred Stock be issued upon any exercise of this Warrant. If, upon exercise
of this Warrant in its entirety, the Holder would, except as provided in this
Section 6, be entitled to receive a fractional share of Preferred Stock, then
the Company shall issue the next higher number of full shares of Preferred
Stock, issuing a full share with respect to such fractional share.

     7.     EXPIRATION DATE; AUTOMATIC EXERCISE. This Warrant shall expire at
the close of business on the earlier to occur of (i) May 21, 2010, or (ii) two
years after the closing of the initial Public Offering; of the Company on the
NASDAQ or other stock exchange in the United States, and shall be void
thereafter (the "EXPIRATION DATE").

                                        3
<Page>

     Notwithstanding the term of this Warrant fixed pursuant to this Section 7,
and provided Holder has received advance written notice of at least twenty (20)
days and has not earlier exercised this Warrant, and provided this Warrant has
not been assumed by the successor entity (or parent thereof), upon the
consummation of a Merger (as defined below), this Warrant shall automatically be
exercised pursuant to Section 4 hereof, without any action by Holder. "MERGER"
means: (i) a sale of all or substantially all of the Company's assets to an
Unaffiliated Entity (as defined below), or (ii) the merger, consolidation or
acquisition of the Company with, into or by an Unaffiliated Entity (other than a
merger or consolidation for the principle purpose of changing the domicile of
the Company or a bona fide round of preferred stock equity financing), that
results in the transfer of fifty percent (50%) or more of the outstanding voting
power of the Company. "UNAFFILIATED ENTITY" means any entity that is owned or
controlled by parties who own less than twenty percent (20%) of the combined
voting power of the voting securities of the Company immediately prior to such
merger, consolidation or acquisition. The Company agrees to promptly give the
Holder written notice of any proposed Merger and written notice of termination
of any proposed Merger. Notwithstanding anything to the contrary in this
Warrant, the Holder may rescind any exercise of its purchase rights after a
notice of termination of the proposed Merger if the exercise of this Warrant
occurred after the Company notified the Holder that the Merger was proposed or
if the exercise was otherwise precipitated by such proposed Merger, provided,
however that such rescission right must be exercised within thirty (30) days of
receipt of such written notice of termination of the proposed Merger. In the
event of such rescission, this Warrant will continue to be exercisable on the
same terms and conditions.

     8.     RESERVED SHARES; VALID ISSUANCE. The Company covenants that it will
at all times from and after the date hereof reserve and keep available such
number of its authorized shares of Preferred Stock and Common Stock free from
all preemptive or similar rights therein, as will be sufficient to permit,
respectively, the exercise of this Warrant in full and the conversion into
shares of Common Stock of all shares of Preferred Stock receivable upon such
exercise. The Company further covenants that such shares as may be issued
pursuant to such exercise and/or conversion will, upon issuance, be duly and
validly issued, fully paid and nonassessable and free from all taxes, liens and
charges with respect to the issuance thereof.

     9.     STOCK SPLITS AND DIVIDENDS. If after the date hereof the Company
shall subdivide the Preferred Stock, by split-up or otherwise, or combine the
Preferred Stock, or issue additional shares of Preferred Stock in payment of a
stock dividend on the Preferred Stock, the number of shares of Preferred Stock
issuable on the exercise of this Warrant shall forthwith be proportionately
increased in the case of a subdivision or stock dividend, or proportionately
decreased in the case of a combination, and the Purchase Price shall forthwith
be proportionately decreased in the cast of a subdivision or stock dividend, or
proportionately increased in the case of a combination.

     10.    ADJUSTMENTS FOR DILUTING ISSUANCES. The other antidilution rights
applicable to the Preferred Stock and the Common Stock of the Company are set
forth in the Amended and Restated Certificate of Incorporation, as amended from
time to time (the "ARTICLES"), a true and complete copy in its current form
which is attached hereto as EXHIBIT A. Such rights shall not be restated,
amended or modified in any manner which affects the Holder differently than the
holders of Series E-1 Preferred without such Holder's prior written consent The
Company shall

                                        4
<Page>

promptly provide the Holder hereof with any restatement, amendment or
modification to the Articles promptly after the same has been made.

     11.    MERGERS AND RECLASSIFICATIONS. Except in connection with an exercise
under SECTION 7, if after the date hereof the Company shall enter into any
Reorganization (as hereinafter defined), then, as a condition of such
Reorganization, lawful provisions shall be made, and duly executed documents
evidencing the same from the Company or its successor shall be delivered to the
Holder, so that the Holder shall thereafter have the right to purchase, at a
total price not to exceed that payable upon the exercise of this Warrant in
full, the kind and amount of shares of stock and other securities and property
receivable upon such Reorganization by a holder of the number of shares of
Preferred Stock which might have been purchased by the Holder immediately prior
to such Reorganization, and in any such case appropriate provisions shall be
made with respect to the rights and interest of the Holder to the end that the
provisions hereof (including without limitation, provisions for the adjustment
of the Purchase Price and the number of shares issuable hereunder and the
provisions relating to the net issue election) shall thereafter be applicable in
relation to any shares of stock or other securities and property thereafter
deliverable upon exercise hereof. For the purposes of this SECTION 11, the term
"REORGANIZATION" shall include without limitation any reclassification, capital
reorganization or change of the Preferred Stock (other than as a result of a
subdivision, combination or stock dividend provided for in SECTION 9 hereof), or
any consolidation of the Company with, or merger of the Company into, another
corporation or other business organization (other than a merger in which the
Company is the surviving corporation and which does not result in any
reclassification or change of the outstanding Preferred Stock), or any sale or
conveyance to another corporation or other business organization of all or
substantially all of the assets of the Company.

     12.    CERTIFICATE OF ADJUSTMENT. Whenever the Purchase Price is adjusted,
as herein provided, the Company shall promptly deliver to the Holder a
certificate of the Company's chief financial officer setting forth the Purchase
Price after such adjustment and setting forth a brief statement of the facts
requiring such adjustment.

     13.    NOTICES OF RECORD DATE, ETC. In the event of:

            (a)    any taking by the Company of a record of the holders of any
class of securities for the purpose of determining the holders thereof who are
entitled to receive any dividend or other distribution, or any statutory right
to subscribe for, purchase, sell or otherwise acquire or dispose of any shares
of stock of any class or any other securities or property, or to receive any
other right;

            (b)    any reclassification of the capital stock of the Company,
capital reorganization of the Company, consolidation or merger involving the
Company, or sale or conveyance of all or substantially all of its assets; or

            (c)    any voluntary or involuntary dissolution, liquidation or
winding-up of the Company;

                                        5
<Page>

then in each such event the Company will provide or cause to be provided to the
Holder a written notice thereof. Such notice shall be provided at least twenty
(20) business days prior to the date specified in such notice on which any such
action is to be taken.

     14.    REPRESENTATIONS, WARRANTIES AND COVENANTS. This Warrant is issued
and delivered by the Company and accepted by each Holder on the basis of the
following representations, warranties and covenants made by the Company:

            (a)    The Company has all necessary authority to issue, execute and
deliver this Warrant and to perform its obligations hereunder. This Warrant has
been duly authorized issued, executed and delivered by the Company and is the
valid and binding obligation of the Company, enforceable in accordance with its
terms.

            (b)    The shares of Preferred Stock issuable upon the exercise of
this Warrant have been duly authorized and reserved for issuance by the Company
and, when issued in accordance with the teams hereof, will be validly issued,
fully paid and nonassessable.

            (c)    The issuance, execution and delivery of this Warrant do not,
and the issuance of the shares of Preferred Stock upon the exercise of this
Warrant in accordance with the terms hereof will not, (i) violate or contravene
the Company's Articles or by-laws, or any law, statute, regulation, rule,
judgment or order applicable to the Company, (ii) violate, contravene or result
in a breach of default under any contract, agreement or instrument to which the
Company is a party or by which the Company or any of its assets are bound or
(iii) require the consent or approval of or the filing of any notice or
registration with any person or entity except for such consents or approvals as
have been obtained as of the date hereof.

            (d)    So long as this Warrant has not terminated or any shares of
Preferred Stock issued upon exercise of this Warrant are outstanding, Holder
shall be entitled to receive such financial and other information as the Holder
would be entitled to receive under the Stock Purchase Agreement applicable to
the Preferred Stock issuable hereunder without regard or limitation with respect
to minimum holdings of Preferred Stock.

            (e)    As of the date hereof, the authorized capital stock of the
Company consists of (i) 30,000,000 shares of Common Stock, par value $0.0001 per
share, of which 4,137,208 shares are issued and outstanding and 23,589,151
shares have been reserved for issuance upon conversion of Preferred Stock
(including 400,000 shares reserved for issuance upon conversion of shares of
Series E-1 Voting Convertible Preferred Stock issuable upon exercise of this
Warrant with respect to Preferred Stock or for issuance upon exercise of this
Warrant with respect to Common Stock) and (ii) 21,164,763 shares of Preferred
Stock, par value $0.001 per share, of which (A) 875,000 shares have been
designated as Series A Voting Convertible Preferred Stock, all of which shares
are issued and outstanding, (B) 625,000 shares have been designated as Series B
Voting Convertible Preferred Stock, all of which shares are issued and
outstanding, (C) 2,850,000 shares have been designated as Series C-1 Voting
Convertible Preferred Stock, all of which shares are issued and outstanding, (D)
1,148,100 shares have been designated as Series C-2 Non Voting Convertible
Preferred Stock, all of which shares are issued and outstanding, (E) 6,222,220
shares have been designated as Series D Voting Convertible Preferred Shock, all
of which shares are issued or outstanding, (F) 7,111,110 shares have been

                                        6
<Page>

designated as Series E Voting Convertible Preferred Stock, of which 4,444,445
shares are issued and outstanding, and (G) 2,333,334 shares have been designated
as Series E-1 Voting Convertible Preferred Stock, of which 1,333,334 shares are
issued and outstanding and 400,000 shares have been reserved for issuance upon
exercise of this Warrant Attached hereto as EXHIBIT B is a capitalization table
summarizing the capitalization of the Company. Once per calendar quarter, the
Company will provide Holder with a current capitalization table indicating
changes, if any, to the number of outstanding shares of common stock and
preferred stock.

     15.    REGISTRATION RIGHTS. The Company hereby grants to the Holder, on a
pari passu basis with all other parties thereto, all the registration and
related rights of a "holder of Registrable Shares" under Section 9 of that
certain Series E-1 Convertible Preferred Stock Purchase Agreement, dated as of
December 20, 2002, as amended from time to time, among the Company and the other
parties thereto (the "RIGHTS AGREEMENT"), and agrees that any and all shares of
Common Stock held by the Holder issued or issuable upon conversion of the shares
of Preferred Stock issued or issuable upon the exercise of this Warrant (or, if
this Warrant becomes a warrant to purchase shares of Common Stock, Common Stock
issued or issuable upon the exercise of this Warrant) shall be "Registrable
Shares" within the meaning of the Rights Agreement. The Holder agrees to comply
with all obligations of a holder of Registrable Shares under the provisions of
the Rights Agreement, including without limitation the "Lock-Up" and Market
Standstill provisions in Section 9.13 of the Rights Agreement.

     16.    AMENDMENT. The terms of this Warrant may be amended, modified or
waived only with the written consent of the Holder and the Company.

     17.    REPRESENTATIONS AND COVENANTS OF THE HOLDER. This Warrant has been
entered into by the Company in reliance upon the following representations and
covenants of the Holder, which by its execution hereof the Holder hereby
confirms:

            (a)    INVESTMENT PURPOSE. The right to acquire Preferred Stock or
the Preferred Stock issuable upon exercise of the Holder's rights contained
herein will be acquired for investment and not with a view to the sale or
distribution of any part thereof, and the Holder has no present intention of
selling or engaging in any public distribution of the same except pursuant to a
registration or exemption.

            (b)    ACCREDITED INVESTOR. Holder is an "accredited investor'"
within the meaning of the Securities and Exchange Rule 501 of Regulation D, as
presently in effect.

            (c)    PRIVATE ISSUE. The Holder understands (i) that the Preferred
Stock issuable upon exercise of the Holder's rights contained herein is not
registered under the 1933 Act or qualified under applicable state securities
laws on the ground that the issuance contemplated by this Warrant will be exempt
from the registration and qualifications requirements thereof; and (ii) that the
Company's reliance on such exemption is predicated on the representations set
forth in this Section 17.

            (d)    SUITABILITY. The Holder confirms that the Holder understands
and has fully considered for purposes of this investment the risks of this
investment and understands that (i) this investment is suitable only for an
investor which is able to bear the economic

                                        7
<Page>

consequences of losing its entire investment; (ii) the Company is an early-stage
enterprise with limited operating history, and limited revenues and no net
income from operations to date; (iii) the purchase of the Warrant and the
purchase of the shares of Preferred Stock issuable on exercise of this Warrant
is a speculative investment which involves a high degree of risk of loss of the
entire investment; and (iv) there are substantial restrictions on the
transferability of, and there will be no public market for, the shares of
Preferred Stock, and accordingly, it may not be possible for the Holder to
liquidate its investment.

            (e)    LACK OF LIQUIDITY. The Holder confirms that it is able (i) to
bear the economic risk of this investment (ii) to hold the Warrant and any
shares of Preferred Stock purchased by the Holder hereunder for an indefinite
period of time, and (iii) presently to afford a complete loss of the Holder's
investment.

            (f)    FINANCIAL RISK. The Holder has such knowledge and experience
in financial and business matters as to be capable of evaluating the merits and
risks of its investment and has the ability to bear the economic risks of its
investment.

            (g)    ACCESS TO MANAGEMENT. The Holder confirms that, in making the
Holder's decision to acquire the Warrant or purchase shares of Preferred Stock
(or Common Stock) pursuant to the Warrant, the Holder has relied solely upon
independent investigations made by the Holder, and that the Holder has been
given the opportunity to ask questions of, and to receive answers from,
management or other persons acting on behalf of the Company concerning the
Company and the terms and conditions of this investment, and to obtain any
additional information, to the extent such persons possess such information

            (h)    JURISDICTION OF ORGANIZATION.  The Holder has its principal
place of business in the State of California.

            (i)    AUTHORITY. The Holder has full power and authority to
execute, deliver and perform the Warrant in accordance with its terms. The
Holder has not been organized, reorganized, or recapitalized specifically for
the purpose of investing in the Company.

     18.    NOTICES, TRANSFERS, ETC.

            (a)    Any notice or written communication required or permitted to
be given to the Holder may be given by certified mail or delivered to the Holder
at the address most recently provided by the Holder to the Company.

            (b)    Subject to compliance with applicable federal and state
securities laws, this Warrant may be transferred by the Holder with respect to
(i) an affiliate, any or all of the shares purchasable hereunder, and (ii) with
respect to a person that is not an affiliate, all, but not less than all of the
shares purchasable hereunder, provided such transferee is not a competitor of
the Company or an affiliate of such a competitor. Upon surrender of this Warrant
to the Company, together with (i) the assignment notice annexed hereto duly
executed, for transfer of this Warrant in whole or in part by the Holder, (ii)
an executed assignment and assumption agreement whereby the transferee agrees to
be bound by all the terms of this Warrant, (iii) a certificate of the transferee
representing to the Company that the representations and warranties of the
Holder in SECTION 16 are true and correct with respect the transferee as of the
date of

                                        8
<Page>

transfer, and (iv) if requested by the Company or its transfer agent, a legal
opinion addressed to the Company concluding that the transfer is exempt from the
registration requirements of the Securities Act of 1933, as amended, the Company
shall issue a new warrant of the same denomination to the assignee. Upon
surrender of this Warrant to the Company, together with the assignment hereof
properly endorsed by the Holder for transfer with respect to a portion of the
shares of Preferred Stock purchasable hereunder, the Company shall issue a new
warrant to the assignee, in such denomination as shall be requested by the
Holder hereof, and shall issue to such Holder a new warrant covering the number
of shares in respect of which this Warrant shall not have been transferred.

            (c)    In case this Warrant shall be mutilated, lost, stolen or
destroyed the Company shall issue a new warrant of like tenor and denomination
and deliver the same (i) in exchange and substitution for and upon surrender and
cancellation of any mutilated Warrant, or (it) in lieu of any Warrant lost,
stolen or destroyed, upon receipt of an affidavit of the Holder and indemnity
reasonably acceptable to the Company and other evidence reasonably satisfactory
to the Company of the loss, theft or destruction of such Warrant.

     19.    GOVERNING LAW. The provisions and terms of this Warrant shall be
governed by and construed in accordance with the internal laws of the State of
Delaware without giving effect to its principles regarding conflicts of laws.

     20.    SUCCESSORS AND ASSIGNS. This Warrant shall be binding upon the
Company's successors and assigns and shall inure to the benefit of the Holder's
successors, legal representatives and permitted assigns.

     21.    BUSINESS DAYS. If the last or appointed day for the taking of any
action required or the expiration of any rights granted herein shall be a
Saturday or Sunday or a legal holiday in California, then such action may be
taken or right may be exercised on the next succeeding day which is not a
Saturday or Sunday or such a legal holiday.

     22.    CONVERSION TO COMMON STOCK WARRANT. If, for any reason, all
outstanding shares of Preferred Stock are converted into shares of Common Stock
prior to the exercise in full of this Warrant (a "Common Stock Conversion"),
then, effective upon such conversion, this Warrant shall automatically and
without any further action on the part of the Company or the Holder become a
Warrant for the purchase of shares of Common Stock. The Holder shall thereupon
have the right to purchase that number of shares of Common Stock equal to the
number of shares of Common Stock which would have been receivable by the Holder
if the Holder had exercised this Warrant for shares of Preferred Stock
immediately prior to the Common Stock Conversion and had participated in the
Common Stock Conversion (the "Common Stock Number"), at a price per share of
Common Stock equal to (x) the total, price payable upon the exercise of this
Warrant in full, divided by (y) the Common Stock Number. In such event
appropriate provisions shall be made with respect to the rights and interest of
the Holder to the end that the provisions hereof (including, without limitation,
the provisions for the adjustment of the Purchase Price and of the number of
shares purchasable upon exercise of this Warrant) shall thereafter be applicable
to any shares of Common Stock deliverable upon the exercise hereof.

                                        9
<Page>

     23.    VALUE. The Company and the Holder agree that the value of this
Warrant on the date of grant is $100.

Dated:  May 21, 2003

                                              NEUROMETRIX, INC.

                                              By: /s/ Shai N. Gozani
                                                 --------------------

                                              Name: Shai N. Gozani

                                              Title: President and CEO

                                       10
<Page>

                                  SUBSCRIPTION

To: ___________________

Date: _________________

The undersigned hereby subscribes for ______ shares of Preferred Stock covered
by this Warrant. The certificate(s) for such shares shall be issued in the name
of the undersigned or as otherwise indicated below:

                                              ----------------------------------
                                              Signature

                                              ----------------------------------
                                              Name for Registration

                                              ----------------------------------
                                              Mailing Address

                                       11
<Page>

                            NET ISSUE ELECTION NOTICE

To: ___________________                                  Date: _________________

The undersigned hereby elects under SECTION 4 to surrender the right to purchase
shares of Preferred Stock pursuant to this Warrant. The certificate(s) for such
shares issuable upon such net issue election shall be issued in the name of the
undersigned or as otherwise indicated below:

                                              ----------------------------------
                                              Signature

                                              ----------------------------------
                                              Name for Registration

                                              ----------------------------------
                                              Mailing Address

                                       12
<Page>

                                   ASSIGNMENT

For value received ____________ hereby sells, assigns and transfers unto
________________ [Please print or typewrite name and address of Assignee] the
within Warrant, and does hereby irrevocably constitute and appoint ____________
its attorney to transfer the within Warrant on the books of the within named
Company with full power of substitution on the premises.

                                              Dated:
                                                    ----------------------------

                                              ----------------------------------
                                              Signature

                                              ----------------------------------
                                              Name for Registration

                                              In the Presence of:

                                              ----------------------------------

                                       13

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