Document:

EXHIBIT
10.143

FIRST
AMENDMENT

TO THE

2006 EQUITY INCENTIVE PLAN

OF

COUNTRYWIDE FINANCIAL CORPORATION

WHEREAS, the Compensation
Committee of the Board of Directors of Countrywide Financial Corporation (the “Company”) has determined that it is in the
best interest of the Company to amend the Countrywide Financial Corporation
2006 Equity Incentive Plan (the “2006 Plan”)
to amend the definition of “Fair Market Value” to conform to certain revised
rules of the Securities and Exchange Commission;

NOW THEREFORE, the 2006 Plan is
amended effective as of January 1, 2007 in the following particulars:

1.             Section 8.1(m) is hereby deleted in its entirety and new
Section 8.1(m) is inserted in its place as follows (with the revised language
reflected below in italics):

“(m)        “Fair Market Value”
shall, on any date, mean the officially-quoted
closing selling price of the shares on such date on the principal national
securities exchange on which such shares are listed or admitted to trading
(including the New York Stock Exchange, Nasdaq Stock Market, Inc. or such other
market or exchange in which such prices are regularly quoted) or, if
there have been no sales with
respect to shares on such date, the Fair Market Value shall be the value
established by the Board in good faith and in accordance with Code Section 422.”

IN
WITNESS WHEREOF, the Company has caused this First Amendment
to be executed by its duly authorized officer this 30th day of November, 2006.

	
  

  	
  Countrywide Financial Corporation

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  By:

  	
  /s/ Marshall M. Gates

  
	
   

  	
   

  	
  Marshall Gates

  
	
   

  	
   

  	
  Senior Managing Director,

  
	
   

  	
   

  	
  Chief Administrative OfficerEXHIBIT
10.144

SIXTH
AMENDMENT

TO THE

GLOBAL STOCK PLAN

OF

COUNTRYWIDE FINANCIAL CORPORATION

WHEREAS, the Compensation
Committee of the Board of Directors of Countrywide Financial Corporation (the “Company”) has determined that it is in the
best interest of the Company to amend the Countrywide Financial Corporation
Global Stock Plan (the “Global Stock Plan”)
to amend the definition of “Fair Market Value” to conform to certain revised
rules of the Securities and Exchange Commission;

NOW THEREFORE, the Global Stock
Plan is amended effective as of January 1, 2007, in the following particulars:

1.             Section 2.11 is hereby deleted in its entirety and new
Section 2.11 is inserted in its place as follows (with the revised language
reflected below in italics):

“2.11       “Fair Market Value”
on any date means the  officially-quoted closing selling price of the shares of Common Stock on such date on the principal national
securities exchange or other stock market on which such shares are listed or
admitted to trading (including the New York
Stock Exchange, Nasdaq Stock Market, Inc. or such other market or exchange in
which such prices are regularly quoted) or, if there have been no sales with
respect to shares on such date, the Fair Market Value shall be the value
established by the Board in good faith and in accordance with Section 422 of the Code.”

IN
WITNESS WHEREOF, the Company has caused this Sixth Amendment
to be executed by its duly authorized officer this 30th day of November, 2006.

	
  

  	
   

  	
  Countrywide Financial Corporation

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  By:

  	
   

  	
  /s/ Marshall M. Gates

  
	
   

  	
   

  	
   

  	
   

  	
  Marshall Gates

  
	
   

  	
   

  	
   

  	
   

  	
  Senior Managing Director,

  
	
   

  	
   

  	
   

  	
   

  	
  Chief Administrative OfficerEXHIBIT 10.1

Employment
Agreement

THIS EMPLOYMENT AGREEMENT (this “Agreement”)
made effective as of the 7th day of May 2007 (the “Effective Date”), by and
between Advanced Life Sciences, Inc., an Illinois corporation (the “Company”),
and Michael J. Cogan (the “Executive”).

WHEREAS, the Company and the Executive desire to enter
into this Agreement, effective as of the Effective Date; and

WHEREAS,
the Company desires to employ the Executive in accordance with the terms and
conditions hereinafter set forth and the Executive desires to be so employed;
and

WHEREAS, the Company has
agreed with the Executive that this Agreement shall set forth the terms and
conditions of the Executive’s employment with the Company;

NOW, THEREFORE, in
consideration of the mutual covenants contained herein, the Company and the
Executive agree as follows:

1.             Term.  The employment of the Executive by the
Company pursuant to this Agreement shall begin as of the Effective Date and
shall expire on the third anniversary of the Effective Date (the “Term”),
unless extended, as set forth below, or otherwise terminated pursuant to the
provisions of this Agreement; provided, however, that commencing
on the third anniversary of the Effective Date and on each anniversary
thereafter, the Term of this Agreement shall automatically be extended for one
additional year unless, not later than 90 days prior to such anniversary, the
Executive or the Company shall have given notice in writing that he or it does
not wish to extend this Agreement.

2.             Position and Duties.  The Executive shall serve as the Vice
President and Controller of the Company, and shall have such responsibilities,
duties and authority as are assigned by the Chief Financial Officer of the
Company and are customarily associated with such position, including but not
limited to, those he may have as of the Effective Date.  The Executive shall devote such time to the
performance of his duties as is necessary to satisfactorily perform his
responsibilities and duties.

3.             Place of Performance.  In connection with the Executive’s employment
by the Company, the Executive shall be based at the principal executive offices
of the Company currently in Woodridge, Illinois, except for required travel on
the Company’s business.

4.             Compensation and Related Matters.  During the Term of the Executive’s
employment, as compensation and consideration for the performance by the
Executive of the Executive’s duties, responsibilities and covenants pursuant to
this Agreement, the Company shall pay the Executive and the Executive agrees to
accept in full payment for such performance the amounts and benefits set forth
below.

(a)           Salary.  The
Company shall pay to the Executive an annual base salary of $180,000 (“Base
Salary”), payable in substantially equal installments no less frequently than
monthly in accordance with the Company’s applicable payroll practices.  The amount of Base Salary shall be reviewed
annually by the Chief Executive Officer to determine whether to increase the
Base Salary on a prospective basis and may be increased by the Compensation
Committee of the Board.  Any such salary
adjustment shall then be considered Base Salary for the purposes of this
Agreement. The Executive’s Base Salary shall not be reduced after any increase,
without the Executive’s consent.

(b)           Bonus.  The Executive shall be eligible to
participate throughout the Term in the Company’s annual bonus plan or any
similar or successor bonus plan (“Bonus Plan”) in accordance with the
Company’s compensation practices and the terms and provisions of the Bonus
Plan.  The Executive may be eligible to
receive an annual performance bonus equal to twenty five percent (25%) of Base
Salary or such greater amount as the Compensation Committee of the Board of
Directors may determine.   The amount of
Bonus shall be reviewed annually and may be increased by the Compensation
Committee of the Board of Directors.

(c)           Stock
Incentive Plan.  As of the Effective
Date, the Executive shall be eligible to receive additional awards of the
Company’s common stock under the Company’s Stock Incentive Plan or under any
other 

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equity
plan of the Company as determined by the Compensation Committee of the Board of
Directors of the Company at its discretion.

(d)           Other Benefits and Perquisites.  During the Term of the Executive’s employment
hereunder:

(i)  Benefit
Plans.  The Executive shall be
entitled to participate in or receive benefits under any employee pension or
welfare benefit plan or arrangement made available by the Company at any time
during his employment hereunder to its employees (collectively the “Benefit
Plans”), including without limitation each qualified retirement plan, life
insurance and accident plan, medical, dental insurance plans, and disability
plan, subject to and on a basis consistent with the terms, conditions and
overall administration of such plans and arrangements, as they may be amended
from time to time.

(ii) Vacation.  The Executive shall be entitled to not less
than twenty (20) days of paid vacation in each calendar year, in accordance
with the Company’s vacation policy.

(iii)          Expense Reimbursement.  The Executive shall be entitled to receive
reimbursement for all reasonable business, travel or other out-of-pocket
expenses incurred by the Executive in fulfilling the Executive’s duties and
responsibilities hereunder, provided that such expenses are incurred and
accounted for in accordance with the policies and procedures established by the
Company.

5.             Termination.

(a)           The Executive’s employment hereunder
may be terminated under the following circumstances:

(i)            The death of the Executive;

(ii)           By the Company for “Cause”, which shall mean any of the
following, as determined by the Board at its discretion and with the assistance
of legal counsel:  (A) conviction of or
plea of guilty or nolo contendere
to any criminal violation involving dishonesty or fraud; (B) engagement in
conduct that is injurious to the Company; (C) engagement in any act of
dishonesty or misconduct that results in damage to the Company or its business
or reputation or that the Board determines to adversely affect the value,
reliability or performance of the Executive to the Company; (D) refusal or
failure to substantially comply with the Company’s human resources rules,
policies, directions and/or restrictions relating to harassment and/or
discrimination, or with compliance or risk management rules, policies,
directions and/or restrictions; (E) unauthorized use or disclosure of
Confidential Information (as defined below) or other trade secrets of the
Company; (F) loss of any license or registration that is necessary for the
Executive to perform his duties to the Company, or commission of any act that
could result in the legal disqualification of the Executive from being employed
by the Company or any of its affiliates; (G) failure to cooperate with the
Company or any of its affiliates in any internal investigation or
administrative, regulatory or judicial proceeding; or (H) continuous failure by
the Executive to perform his duties to the Company (which may include any
sustained and unexcused absence of the Executive from the performance of such
duties, which absence has not been certified in writing as due to physical or
mental illness or disability), after a written demand for performance has been
delivered to the Executive identifying the manner in which the Executive has
failed to substantially perform such duties. 
The application of any part of the definition of Cause set forth in
clauses (A) through (H) above to the Executive shall not preclude or prevent
the reliance by the Company or the Board on any other part of the definition
that also may be applicable.  In
addition, the Executive’s employment shall be deemed to have terminated for
Cause if, after the Executive’s employment has terminated, facts and
circumstances are discovered that would have justified a termination for Cause.

(iii)          By mutual agreement between the Company and the Executive;
or

(iv)          By the Executive or the Company for
any reason other than as stated in Sections 5(a)(i) through 5(a)(iii) above,
upon providing a Notice of Termination (as defined in Section 5(b)).

(b)           Notice of Termination.  Any termination of the Executive’s employment
by the Company or by the Executive (other than a termination pursuant to
Section 5(a)(i) above) shall be communicated by written Notice of Termination
to the other party hereto in accordance with Section 10.  For purposes of this Agreement, a “Notice of
Termination” shall mean a notice that shall indicate the specific termination
provision in this Agreement relied upon 

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and
shall set forth in reasonable detail the facts and circumstances claimed to
provide a basis for termination of the Executive’s employment under the
provision so indicated.

(c)           “Date of Termination” shall mean (i) if the Executive’s
employment is terminated pursuant to Section 5(a)(i) above, the date of his
death; (ii) if the Executive’s employment is terminated pursuant to Section
5(a)(ii) or 5(a)(iv) above, the date such Notice of Termination is given (or
such later date as provided therein); (iii) if the Executive’s employment is
terminated pursuant to Section 5(a)(iii) above, the date mutually agreed to by
the parties; (iv) the date the Term of this Agreement expires, if either the
Company or the Executive provides notice in accordance with Section 1; or (v)
if the Executive terminates his employment and fails to provide written notice
to the Company of such termination, the date of such termination.

6.             Compensation Upon Termination.

(a)           The following payments shall be made upon the Executive’s
termination of employment for any reason: 
(i) earned but unpaid Base Salary through the Executive’s Date of
Termination; (ii) any accrued but unpaid vacation; (iii) unreimbursed business
expenses owed pursuant to Section 4(d)(iii); and (iv) any amounts payable under
any of the Company’s Benefit Plans in accordance with the terms of those
plans.  All amounts under clauses (i)
through (iii) shall be paid in a lump sum on the Executive’s Date of
Termination or as soon as administratively practicable thereafter.

(b)           In the event that the Executive’s
employment is terminated pursuant to Sections 5(a)(i) or 5(a)(ii), or by the
Executive for any reason  pursuant
to Section 5(a)(iv), above, the Company shall have no further obligation to the
Executive under this Agreement, other than the payments in Section 6(a).

(c)           If the Executive’s employment is
terminated by the parties pursuant to Section 5(a)(iii) above, the Executive
shall be entitled to receive the compensation the parties specify in any
written agreement that the Company and the Executive execute regarding the
Executive’s termination.

(d)           In addition to the payments made
under Section 6(a), if the Executive’s employment is terminated by the Company
without Cause pursuant to Section 5(a)(iv) above, the Company shall, for a
period of four (4) months following the Date of Termination and conditioned
upon the Executive’s execution of a valid and legally enforceable release of
claims, (i) provide to Executive salary continuation, at Executive’s Base
Salary rate then in effect, and (ii) continue the Executive’s coverage under
the Benefit Plans in which the Executive participated immediately prior to the
Date of Termination, provided, however, that if the Company cannot continue
such coverage, the Company shall provide or arrange to provide, at its expense,
similar coverage to the Executive. 
Notwithstanding the forgoing, vacation days shall not accrue during the
four (4) month period of severance.

(e)           The Executive shall not be required to mitigate the amount
of any payment provided for in this Section 6 by seeking other employment or
otherwise, nor shall the amount of any payment or benefit provided for in this
Section 6 be reduced by any compensation earned by the Executive as the result
of employment by another employer, by retirement benefits, by offset against
any amount claimed to be owed by the Executive to the Company, or otherwise.

(f)            The obligations of the Company to make payments and
provide benefits under this Section 6 shall survive the termination of this
Agreement.

7.             Change in Control.  Upon a Change in Control, all outstanding
stock options and other equity awards under the Company’s Stock Incentive Plan
or other similar or successor plan held by the Executive will immediately
become fully vested and exercisable.

(a)           Payments and Benefits Upon Employment
Termination Upon a Change in Control.  If
the Executive’s employment is terminated other than for Cause within 24 months
after a Change in Control (as defined below), the Company shall provide the
following payments and benefits to the Executive, in lieu of those payments and
benefits provided under Sections 6(d), but in addition to the amounts payable
under Section 6(a):

(i)            The Company shall pay the Executive
a lump sum cash amount equal to two (2) times the sum of (A) the Executive’s
Base Salary as in effect on the date of the Executive’s termination of
employment and (B) the Executive’s target bonus amount for the fiscal year in
which the Executive’s 

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employment is
terminated OR an amount equal to the annual bonus paid to the Executive during
the fiscal year immediately preceding the Executive’s termination of
employment.

(ii)           The Company shall continue the
Executive’s coverage under the Benefit Plans in which the Executive
participated immediately prior to the Executive’s termination of employment for
a period of 24 months, provided, however, that if the Company cannot continue
such coverage, the Company shall provide or arrange to provide, at its expense,
similar coverage to the Executive.

(b)           Timing of Payment.  All payments under Section 7(a) shall be made
in a lump sum cash payment as soon as practicable, but in no event more than 10
days after the Executive’s termination of employment.

(c)           Definitions.  For purposes of this Agreement, the following
terms shall have the following definitions:

(i)  “Change in
Control” means the occurrence of any one or more of the following:

(A)          Any “person” (as such term is defined
in Section 3(a)(9) of the Securities Exchange Act of 1934, as amended (the “Exchange
Act”) and as used in Sections 13(d)(3) and 14(d)(2) of the Exchange Act),
including a “group” (as defined in Section 13(d)(3) of the Exchange Act), other
than (I) the Company, (II) any wholly-owned subsidiary of the Company, (III)
any employee benefit plan (or related trust) sponsored or maintained by the
Company or any of its affiliates, or (IV) a “Permitted Holder” (as defined
below), becomes a “beneficial owner” (as defined in Rule 13d-3 under the
Exchange Act), directly or indirectly, of securities of the Company having fifty
percent (50%) or more of the combined voting power of the then-outstanding
securities of the Company that may be cast for the election of directors of the
Company (other than as a result of an issuance of securities initiated by the
Company in the ordinary course of business) (the “Company Voting Securities”);
provided, however, that the event described in this Section 7(c)(i) shall not
be deemed to be a Change in Control by virtue of any underwriter temporarily
holding securities pursuant to an offering of such securities;

(B)           During any period of two consecutive
years, individuals who at the beginning of any such period constitute the Board
(the “Incumbent Directors”) cease for any reason to constitute at least a
majority of the Board, unless the election, or the nomination for election by
the stockholders of the Company, of each new director of the Company during
such period was approved by a vote of at least two-thirds of the Incumbent
Directors then still in office;

(C)           As the result of, or in connection
with, any cash tender or exchange offer, merger or other business combination,
sale of all or substantially all of the Company’s assets or contested election,
or any combination of the foregoing transactions, less than a majority of the
combined voting power of the then-outstanding securities of the Company or any
successor corporation or entity entitled to vote generally in the election of
the directors of the Company or such other corporation or entity after such
transaction is held in the aggregate by the holders of the securities of the
Company entitled to vote generally in the election of directors of the Company
immediately prior to such transaction; or

(D)          The stockholders of the Company
approve a plan of complete liquidation or dissolution of the Company.

Notwithstanding the
foregoing, a Change in Control shall not be deemed to occur solely because any
person acquires beneficial ownership of more than fifty percent (50%) of the
Company Voting Securities as a result of the acquisition of Company Voting
Securities by the Company which reduces the number of Company Voting Securities
outstanding; provided, however, that if after such acquisition by the Company
such person becomes the beneficial owner of additional Company Voting
Securities that increases the percentage of outstanding Company Voting
Securities beneficially owned by such person, a Change in Control transaction
shall then occur.

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Further notwithstanding
the foregoing, unless a majority of the Incumbent Directors determines
otherwise, no Change in Control shall be deemed to have occurred with respect
to the Executive if the Change in Control results from actions or events in
which the Executive is a participant in a capacity other than solely as an
officer, employee or director of the Company or any of its affiliates.

(ii)           “Permitted Holders” means (A) Michael
T. Flavin (the “Principal”), (B) the spouse or any immediate family member of
the Principal and any child or spouse of any spouse or immediate family member
of the Principal, (C) a trust, corporation, partnership or other entity, the
beneficiaries, stockholders, partners, owners or persons beneficially holding,
directly or indirectly, a controlling interest of which consists of the
Principal and/or such other persons referred to in the immediately preceding
clause (B), or (D) the trustees of any trust referred to in clause (D).

(d)           Treatment of Parachute Payments.

(i)            Notwithstanding any other provisions
of this Agreement, and except as set forth below, in the event that any payment
or benefit received or to be received by the Executive in connection with a
Change in Control or the termination of the Executive’s employment (whether
pursuant to the terms of this Agreement or any other plan, arrangement or
agreement with the Company, any person whose actions result in a Change in
Control or any person affiliated with the Company or such person) (all such
payments and benefits, including payments under Section 7(a) above, being
hereinafter called “Total Payments”) is determined to be an “excess parachute
payment” pursuant to Section 280G of the Internal Revenue Code of 1986, as
amended (the “Code”), or any successor or substitute provision of the Code,
with the effect that the Executive is liable for the payment of the excise tax
described in Code Section 4999 or any successor or substitute provision of the
Code (the “Excise Tax”), then, after taking into account any reduction in the
Total Payments provided by reason of Code Section 280G in such other plan,
arrangement or agreement, the cash payments provided in Section 7(a)(i) of this
Agreement shall first be reduced, and the noncash payments and benefits shall
thereafter be reduced, to the extent necessary so that no portion of the Total
Payments is subject to the Excise Tax; provided, however, that the Executive
may elect (at any time prior to the payment of any Total Payment under this
Agreement) to have the noncash payments and benefits reduced (or eliminated)
prior to any reduction of the cash payments under this Agreement.

(ii)           All determinations required to be
made under this Section 7(d), and the assumptions to be utilized in arriving at
such determination, shall be made by the certified public accounting firm used
for auditing purposes by the Company immediately prior to the date of the Executive’s
termination of employment or, if the parties determine that such certified
public accounting firm cannot make such determination because of legal
restrictions, the parties shall agree on a different certified public
accounting firm (such certified public accounting firm is hereinafter referred
to as the “Accounting Firm”), which shall provide detailed supporting
calculations both to the Company and the Executive not later than 5 days prior
to the date of the Executive’s termination of employment.  The Company shall pay all fees and expenses
of the Accounting Firm.  Any
determination by the Accounting Firm shall be binding upon the Company and the
Executive, except as provided in paragraph (iii) below.

(iii)          As a result of the uncertainty in the
application of Code Sections 280G and 4999 at the time of the initial
determination by the Accounting Firm hereunder, it is possible that the
Internal Revenue Service (the “IRS”) or other agency will claim that an Excise
Tax, or a greater Excise Tax, is due.  If
the Executive is required to make a payment of any such Excise Tax, the Company
will promptly pay the Executive an additional amount equal to the amount, or
greater amount, of Excise Tax the Executive is required to pay (plus a gross up
payment for any income taxes, interest, penalties or additional Excise Tax
payable by Executive with respect to such Excise Tax or additional payment), as
determined by the Accounting Firm.  The
Executive will notify the Company in writing of any claim by the IRS or other
agency that, if successful, would require payment by the Company of the
additional payments under this paragraph. 
The Executive and the Company shall each reasonably cooperate with the
other in connection with any administrative or judicial proceedings concerning
the existence or amount of liability for Excise Tax with respect to the Total
Payments.  The Company shall pay all fees
and expenses of the Executive relating to a claim by the IRS or other agency.

8.             Restrictive
Covenants.

 6
 

(a)           Trade Secrets.  The Executive acknowledges that he has had and
shall have access to confidential information of the Company, whether or not
reduced to writing and whether in paper, electronic, digital, analog or other
format (including, but not limited to, trade secrets, know-how, Inventions (as
defined below), new product and product development information, research
results, marketing and sales programs, customer and supplier information,
financial data, employee records, cost information, pricing information, sales
and marketing strategies, the identity of customers, information received by
the Company under an obligation of confidentiality to customers, and all
information generated by the Company for customers) relating to the past,
present or planned business, customers, clients, contacts, prospects and assets
of the Company that is unique, valuable and has not purposefully been made
generally known to the public by the Company (“Confidential Information”).  Confidential Information shall not include
any information that: (i) is now, or hereafter becomes, through no act or
failure to act on the part of the Executive that constitutes a breach of this
Section 8, generally known or available to the public; (ii) is hereafter
furnished without restriction on disclosure to the Executive by a third party,
other than an employee or agent of the Company, who is not under any obligation
of confidentiality to the Company; (iii) is disclosed with the written approval
of the Company; or (iv) is required to be disclosed or provided by law, court
order, or similar compulsion, including pursuant to or in connection with any
legal proceeding involving the parties hereto; provided, however, that such
disclosure shall be limited to the extent so required or compelled; and
provided further, however, that if the Executive is required to disclose such
Confidential Information, the Executive shall give the Company notice of such
disclosure and cooperate in seeking suitable protections.  The Executive acknowledges that all
Confidential Information, and all documents, files, reports, drawings, designs,
specifications, formulae, samples, data, writings, tools, equipment, memory
devices or any other tangible objects that incorporate, contain, refer to or
embody any Confidential Information (“Items”), acquired by the Executive in
connection with the Executive’s employment with the Company are the property of
the Company.  Other than in the course of
performing services for the Company or otherwise authorized in writing by the
Company, the Executive shall not, at any time, directly or indirectly use,
divulge, furnish or make accessible to any person any Confidential Information,
but instead shall keep all Confidential Information strictly and absolutely
confidential.  The Executive shall
deliver promptly to the Company, at the termination of his employment or at any
other time at the request of the Company, without retaining any copies, all
Items and any other documents or materials in the Executive’s possession
relating, directly or indirectly, to any Confidential Information.

(b)           Non-competition.  Beginning on the Effective Date and for a
period of  twelve (12) months following
Executive’s Date of Termination (the “Restricted Period”), Executive shall not
directly or indirectly, alone or in conjunction with any other party, own any
interest in, operate, control, engage in or participate as a partner, director,
principal, officer, employee, independent contractor or agent of, act as a
consultant to, perform any services for, or assist in any way any company,
person, or entity in the United States that is engaged in “Competing Services”
(as defined herein).  Competing Services
shall mean chemistry and biology research and development relating to, arising
from, connected with, or competitive with or intended to be competitive with,
any product or research project as to which the Executive performed services
for the Company, or about which the Executive received access to Confidential
Information while employed by the Company. 
If the Executive obtains other employment during the twelve-month period
after the Executive’s Date of Termination, the Executive agrees to notify the
Company in writing of the name and address of such employer.  The Executive understands, and the Company
agrees, that the Company shall pay to the Executive a monthly amount equal to
one month of the Executive’s final Base Salary if the Executive is unable to
secure other employment as a direct result of this Section 8(b).  The Executive agrees and acknowledges that
(i) the Company shall be obligated to make such payment only upon a written
request by the Executive containing sufficient information for the Company to
make a determination that this Section 8(b) caused the Executive’s inability to
secure other employment, and (ii) the Company shall be released from the
obligation to make such payment if the Company provides the Executive a written
release from this Section 8(b).  The
Company’s obligation to make payments under this Section 8(b) shall be made
only for the period beginning with the Executive’s inability to secure other
employment as a result of this Section 8(b) and ending no later than the
expiration of the twelve-month period following the Executive’s Date of
Termination.

(c)           Non-Solicitation of Employees. During
the Restricted Period, the Executive shall not, directly or indirectly solicit
or induce, or attempt to solicit or induce, any current employee of the
Company, or any individual who becomes an employee during the Restricted
Period, to leave his or her employment with the Company or join or become
affiliated with any other business or entity, hire any employee of the Company
or in any way interfere with the relationship between any employee and the
Company.

(d)           Non-Solicitation of Customers.  During the Restricted Period, the Executive
shall not, directly or indirectly, solicit or induce, or attempt to solicit or
induce, any customer, supplier, licensee, licensor or other 

 7
 

business relation
of the Company to terminate its relationship or contract with the Company, to
cease doing business with the Company, or in any way interfere with the
relationship between any such customer, supplier, licensee or business relation
and the Company (including making any negative statements or communications
concerning the Company or their employees).

(e)           Inventions.  The Executive acknowledges all inventions of
the Company (including, but not limited to, procedures, systems, machines,
methods, processes, uses, apparatuses, compositions of matter, designs, or
configurations of any kind, discovered, conceived, reduced to practice,
developed, made or produced) (“Inventions”) that (i) relate to the present or
planned business of the Company or the work performed by the Company for its
customers, and (ii) are conceived or reduced to practice by the Executive,
either alone or with others, during the Executive’s employment with the Company
or during a period of 120 days after the Executive’s Date of Termination,
whether or not done during the Executive’s regular working hours, are the sole
property of the Company, including, without limitation, all domestic and
foreign patent rights, rights of registration or other protection under the
copyright laws, or other rights pertaining to the Inventions.  For purposes of this Agreement, Inventions
shall include any improvements to an Invention and shall not be limited to the
definition of a patentable invention or copyrightable work of authorship as
contained in the United States patent or copyright laws.  The Executive shall disclose promptly and
fully in writing to the Company each Invention, whether or not reduced to
practice, that the Executive conceives or learns (either alone or jointly with
others) during the Term of Employment. 
The Executive hereby assigns to the Company, or its nominee, all of the
Executive’s right, title and interest, including international priority rights,
in and to all Inventions (other than any Invention that was developed entirely
on the Executive’s own time and for which no equipment, supplies, facilities or
trade secret information of the Company was used, unless such Invention relates
directly to the Company’s business or to the Company’s actual or demonstrably
anticipated research or development), and in and to all United States or
foreign patents, copyrights and other proprietary rights granted thereon or
resulting therefrom, and in and to all applications for United States or
foreign copyrights, patents and other proprietary rights.  The Executive shall execute all papers,
perform all lawful acts or assist the Company in any way the Company deems
necessary or advisable (at the Company’s expense) for the preparation, filing,
prosecution, issuance, procurement, maintenance or enforcement of patents
applications and patents of the United States and foreign countries, and for
obtaining and enforcing copyright protection and registration, of any
Invention.  To that end, the Executive
shall at the Company’s request and without limitation, testify in any suit or
other proceeding involving any of the Inventions, execute all documents that
the Company reasonably determines to be necessary or convenient for use in
applying for and obtaining patent or copyright protection and registration on
any of the Inventions and enforcement of that protection and registration, and
execute all necessary documents and papers required to vest title in and assign
to the Company (or its nominee) patent or copyright protection and
registration.  The Executive’s obligation
to assist the Company in obtaining and enforcing patent or copyright protection
and registration for the Inventions shall continue following termination of
this Agreement, but Company shall compensate the Executive following the
expiration or termination of this Agreement at a rate of $10 for the execution
of each document and $150 per day for each day or portion thereof spent at the
Company’s request in rendering assistance, plus reimbursement for the
reasonable out-of-pocket expenses incurred by the Executive for such
assistance.  The Executive hereby
irrevocably appoints the Company and its duly authorized officers and agents as
his agent and attorney-in-fact to act for and on behalf of the Executive in
filing all patent applications, applications for copyright protection and
registration amendments, renewals and all other appropriate documents in any
way related to the Inventions.

(f)            Survival.  The provisions set forth in this Section 8
shall survive termination of this Agreement.

(g)           Scope Limitations.  If the scope, period of time or area of
restriction specified in this Section 8 are or would be judged to be
unreasonable in any court proceeding, then the period of time, scope or area of
restriction shall be reduced or limited in the manner and to the extent
necessary to make the restriction reasonable, so that the restriction may be enforced
in those areas, during the period of time and in the scope that are or would be
judged to be reasonable.

9.             Binding
Agreement; Successors.  This Agreement
and all rights of the Executive hereunder shall inure to the benefit of and be
enforceable by the Executive’s personal or legal representatives, executors,
administrators, successors, heirs, distributees, devisees and legatees.  If the Executive should die while any amounts
would still be payable to him hereunder if he had continued to live, all such
amounts, unless otherwise provided herein, shall be paid in accordance with the
terms of this Agreement to the Executive’s devisee, legatee, or other designee
or, if there be no such designee, to the Executive’s estate.  This Agreement shall be binding upon, and
inure to the benefit of, any successors or assigns of the 

 8
 

Company.  This
Agreement is not intended to confer upon any person other than the parties
hereto (and the Executives’ Spouse and dependents) any rights or remedies,
except as specifically provided in this Section 9.

10.           Notice.  Notices, demands and all other communications
provided for in this Agreement shall be in writing and shall be deemed to have
been duly given when delivered, if delivered personally, or (unless otherwise
specified) when received, if mailed by United States certified or registered
mail, return receipt requested, postage prepaid, by Federal Express or other
reputable overnight courier service or by facsimile, addressed as follows:

If to the Executive:

Michael J. Cogan

1440 Davey Road

Woodridge, Illinois 60517

If to the Company:

Advanced Life Sciences, Inc.

1440 Davey Road

Woodridge, Illinois 60517

Attn: Chief Executive Officer

or to such other address as any party may have
furnished to the other in writing in accordance herewith, except that notices
of change of address shall be effective only upon receipt.

11.           General
Provisions.  No provision of this
Agreement may be modified, waived or discharged unless such waiver,
modification or discharge is agreed to in writing signed by the Executive and
such officer of the Company as may be specifically designated by the Company’s
Board.  No waiver by either party hereto
at any time of any breach by the other party hereto of, or compliance with, any
condition or provision of this Agreement to be performed by such other party
shall be deemed a waiver of similar or dissimilar provisions or conditions at
the same or at any prior or subsequent time. 
No agreements or representations, oral or otherwise, express or implied,
with respect to the subject matter hereof have been made by either party that
are not set forth expressly in this Agreement.

12.           Validity.  The invalidity or unenforceability of any
provision or provisions of this Agreement shall not affect the validity or
enforceability of any other provision of this Agreement, which shall remain in
full force and effect.  If any provision
of this Agreement is found to be invalid or unenforceable, in whole or in part,
then it shall be deemed to be modified or restricted to the extent and in the
manner necessary to render it valid and enforceable, or shall be deemed excised
from this Agreement, as the case may require, and this Agreement shall be
construed and enforced to the maximum extent permitted by law, as if the
provision had been originally incorporated herein as so modified or restricted,
or as if it had not originally been incorporated herein, as the case may be.

13.           Counterparts.  This Agreement may be executed in one or more
counterparts, each of which shall be deemed to be an original but all of which
together shall constitute one and the same instrument.

14.           Entire Agreement.  This Agreement sets forth the entire
agreement of the parties hereto in respect of the subject matter contained
herein and supersedes all prior agreements, promises, covenants, arrangements,
communications, representations or warranties, whether oral or written, by any
officer, employee or representative of any party hereto; and any prior
agreement of the parties hereto in respect of the subject matter contained
herein is hereby terminated and canceled. For the avoidance of doubt, the
Company and the Executive hereby agree that this Agreement shall replace and
supercede the Existing Employment Contract and govern the relationship of the
parties.

15.           Irreparable
Harm.  The Executive acknowledges
that: (i) the Executive’s compliance with this Agreement is necessary to
preserve and protect the proprietary rights, Confidential Information and the
goodwill of the Company and its subsidiaries as going concerns; (ii) any
failure by the Executive to comply with the provisions of this Agreement shall
result in irreparable and continuing injury for which there will be no adequate
remedy at law; and (iii) in the event that the Executive should fail to comply
with the terms and conditions of this Agreement, the Company shall be entitled,
in addition to such other relief as may be proper, to all types of equitable
relief (including, but not limited to, the issuance of an injunction and/or
temporary restraining order) as may be necessary to cause the Executive to
comply with this Agreement, to restore to the Company its property, and to make
the Company whole.

 9
 

16.           Consent
to Jurisdiction and Forum; Legal Fees and Costs.  The Company and the Executive hereby
expressly and irrevocably agree that any action, whether at law or in equity,
arising out of or based upon this Agreement or the Executive’s employment by
the Company shall only be brought in a federal or state court located in Cook
County, Illinois.  The Executive hereby
irrevocably consents to personal jurisdiction in such court and to accept
service of process in accordance with the provisions of such court.  In connection with any dispute arising out of
or based upon this Agreement or the Executive’s employment by the Company, each
party shall be responsible for its or his own legal fees and expenses and all
court costs shall be shared equally by the Company and the Executive unless the
court apportions such legal fees or court costs in a different manner.

17.           Withholding.  All payments made to the Executive pursuant
to this Agreement shall be subject to applicable withholding taxes, if any, and
any amount so withheld shall be deemed to have been paid to the Executive for
purposes of amounts due to the Executive under this Agreement.

18.           Governing
Law.  This Agreement is governed by
and is to be construed and enforced in accordance with the laws of the State of
Illinois, without regard to its conflict of law provisions.

IN WITNESS WHEREOF, the parties have executed this Agreement
on the date and year first above written.

 

	
  EXECUTIVE

  	
   

  	
  ADVANCED
  LIFE SCIENCES, INC.

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  By: 

  	
  /s/ Michael J.
  Cogan

  	
   

  	
  By:

  	
   /s/ Michael
  T. Flavin

  
	
   

  	
   

  	
   

  	
   

  	
  Title:Chief Executive Officer

  

 

 10

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