Document:

exv4w3

Exhibit 4.3

[FORM OF FACE OF NOTE]

     UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST
COMPANY, A NEW YORK CORPORATION (“DTC”), TO THE COMPANY OR ITS AGENT FOR REGISTRATION OF TRANSFER,
EXCHANGE, OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH
OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND ANY PAYMENT IS MADE TO CEDE
& CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY
TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL
INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN. THIS NOTE IS A GLOBAL
NOTE WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A
DEPOSITARY OR A NOMINEE THEREOF. THIS NOTE IS EXCHANGEABLE FOR NOTES REGISTERED IN THE NAME OF A
PERSON OTHER THAN THE DEPOSITARY OR ITS NOMINEE ONLY IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE
INDENTURE AND, UNLESS AND UNTIL IT IS EXCHANGED IN WHOLE OR IN PART FOR NOTES IN DEFINITIVE FORM,
THIS NOTE MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE DEPOSITARY TO A NOMINEE OF THE DEPOSITARY
OR BY A NOMINEE OF THE DEPOSITARY TO THE DEPOSITARY OR ANOTHER NOMINEE OF THE DEPOSITARY OR BY THE
DEPOSITARY OR ANY SUCH NOMINEE TO A SUCCESSOR DEPOSITARY OR A NOMINEE OF SUCH SUCCESSOR
DEPOSITARY.1

 

			
	1	 	This legend is to be included only if the Note is a
Global Note.

1

 

Onyx Pharmaceuticals, Inc.

4.00% Convertible Senior Notes due 2016

			
	 	 	 
	No. 1
	 	U.S. $230,000,000

CUSIP: 683399AB5

ISIN: US683399AB58

     Onyx Pharmaceuticals, Inc., a company duly incorporated and validly existing under the laws of
the State of Delaware (herein called the “Company”), which term includes any successor corporation
under the Indenture referred to on the reverse hereof), for value received hereby promises to pay
to Cede & Co., or registered assigns, the principal sum of [•] United States Dollars ($[•]) (which
amount may from time to time be increased or decreased by adjustments made on the records of the
Trustee, as custodian for the Depositary, in accordance with the rules and procedures of the
Depositary and in accordance with the below referred Indenture) on August 15, 2016.

     The issue date of this Note is August 12, 2009.

     Reference is made to the further provisions of this Note set forth on the reverse hereof,
including, without limitation, provisions giving the Company the right to redeem this Note under
certain circumstances, provisions giving the Holder the right to convert this Note into Common
Stock of the Company and to the ability and obligation of the Company to purchase this Note upon
certain events, in each case, on the terms and subject to the limitations referred to on the
reverse hereof and as more fully specified in the Indenture. Such further provisions shall for all
purposes have the same effect as though fully set forth at this place. Capitalized terms used but
not defined herein shall have such meanings as are ascribed to such terms in the Indenture.

     This Note shall be deemed to be a contract made under the laws of the State of New York, and
for all purposes shall be construed in accordance with and governed by the laws of said State.

[Signature page follows]

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     IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed.

	 	 	 	 	 
	 	ONYX PHARMACEUTICALS, INC.

 	 
	 	By:  	 	 
	 	 	Name:  	 	 
	 	 	Title:  	 	 
	 	Date:	 	 
	 

	 	 	 	 	 
	TRUSTEE’S CERTIFICATION OF

AUTHENTICATION

WELLS FARGO BANK, NATIONAL

ASSOCIATION, as Trustee, certifies
that 
this is one of the Notes
described in the
 within-mentioned
Indenture.

 	 	 
	By:  	 	 	 
	 	Name:  	 	 	 
	 	Authorized Signatory
 	 	 
	Date:	 	 	 
	 

3

 

[FORM OF REVERSE SIDE OF NOTE]

Onyx Pharmaceuticals, Inc.

4.00% Convertible Senior Notes due 2016

     This Note is one of a duly authorized issue of 4.00% Convertible Senior Notes due 2016 (the
“Notes”) of the Company issued under an Indenture, dated as of August 12, 2009 (as amended,
modified and supplemented by the First Supplemental Indenture dated August 12, 2009, the
“Indenture”) between the Company and Wells Fargo Bank, National Association, as trustee (the
“Trustee”). The terms of the Note include those stated in the Indenture, those made part of the
Indenture by reference to the Trust Indenture Act of 1939, as amended (the “TIA”), and those set
forth in this Note. This Note is subject to all such terms, and Holders are referred to the
Indenture and the TIA for a statement of all such terms. To the extent permitted by applicable
law, if any provision of this Note conflicts with the express provisions of the Indenture, the
provisions of the Indenture shall govern and be controlling. Capitalized terms used but not
defined herein have the meanings assigned to them in the Indenture unless otherwise indicated.

     1. Interest.

     This Note shall bear interest at a rate of 4.00% per annum on the principal amount. Interest
on this Note shall accrue from the most recent date to which interest has been paid or, if no
interest has been paid, from August 12, 2009. Interest will be payable semi-annually, in arrears,
on each February 15 and August 15, beginning on February 15, 2010, to holders of record at the
Close of Business on the immediately preceding February 1 and August 1, respectively. Interest
will be computed on the basis of a 360-day year comprised of twelve 30-day months. If a payment
date is not a Business Day, payment will be made on the next succeeding Business Day, and no
interest (including Additional Interest, if any) will accrue for the intervening period.

     Interest (including Additional Interest, if any) will cease to accrue on the Notes upon the
Maturity Date, their redemption by the Company or their conversion or repurchase by the Company at
the option of the Holder.

     2. Method of Payment.

     Payment of the principal of the Notes shall be made at the Corporate Trust Office of the
Trustee in such coin or currency of the United States of America as at the time of payment is legal
tender for payment of public and private debts. Payment of interest including Additional Interest,
if any, on Certificated Notes shall be made by check mailed to the address of the Person entitled
thereto as such address appears in the Security Register; provided, however, that Holders with
Notes in an aggregate principal amount in excess of $5.0 million shall be paid, at their written
election, by wire transfer of immediately available funds.

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Notwithstanding the foregoing, so long as the Notes are registered in the name of a Depositary
or its nominee, all payments with respect to the Notes shall be made by wire transfer of
immediately available funds to the account of the Depositary or its nominee.

     3. Paying Agent, Registrar and Conversion Agent.

     Initially, the Trustee will act as Paying Agent, Registrar and Conversion Agent. The Company
or any Affiliate of the Company may act as Paying Agent, Registrar or Conversion Agent.

     4. Indenture.

     The Notes are general unsecured senior obligations of the Company. The Indenture does not
limit the ability of the Company to incur other debt, secured or unsecured.

     5. Redemption at the Option of the Company.

     The Notes are redeemable in whole, or from time to time in part, at any time on or after
August 20, 2013 at the option of the Company if the Last Reported Sale Price of the Common Stock
for 20 or more Trading Days in a period of 30 consecutive Trading Days ending on the Trading Day
immediately prior to the date of the Redemption Notice exceeds 130% of the applicable Conversion
Price in effect on each such Trading Day. The Redemption Price shall be equal to (i) a cash amount
equal to the sum of (x) 100% of the principal amount of Notes being redeemed, plus (y) accrued and
unpaid interest (including Additional Interest, if any), if any to, but excluding, the Redemption
Date, plus (ii) the Make-Whole Premium payment in cash, shares of Common Stock or a combination
thereof, at our option. No sinking fund is provided for the Notes.

     6. Purchase by the Company at the Option of the Holder Upon a Fundamental
Change.

     Subject to the terms and conditions of the Indenture, the Company shall become obligated to
purchase, at the option of any Holder, all or any portion of the Notes held by such Holder upon a
Fundamental Change in principal amounts of $1,000 or multiples of $1,000 at the Fundamental Change
Repurchase Price. To exercise such right, a Holder shall deliver to the Paying Agent, and the
Paying Agent must receive, a Fundamental Change Repurchase Notice containing the information set
forth in the Indenture, at any time prior to the Close of Business on the Business Day immediately
preceding the Fundamental Change Repurchase Date, and shall deliver the Notes to the Paying Agent
as set forth in the Indenture.

     Holders have the right to withdraw (in whole or in part) any Fundamental Change Repurchase
Notice by delivering to the Paying Agent a written notice of withdrawal in accordance with the
provisions of the Indenture.

5

 

     If cash sufficient to pay the Fundamental Change Repurchase Price of all Notes or portions
thereof to be purchased with respect to a Fundamental Change Repurchase Date is deposited with the
Paying Agent by 10:00 a.m., New York City time, on the Fundamental Change Repurchase Date, then,
immediately after such Fundamental Change Repurchase Date, such Notes shall cease to be outstanding
and interest (including Additional Interest, if any) on such Notes shall cease to accrue, whether
or not such Notes are delivered by their Holders to the Paying Agent, and the Holders thereof shall
have no other rights as such (other than the right to receive the Fundamental Change Repurchase
Price upon delivery of such Notes by their Holders to the Paying Agent).

     7. Conversion.

     Subject to the provisions of the Indenture (including without limitation the conditions of
conversion of Notes set forth in Article 5 thereof), the Holder hereof has the right, at its
option, to convert the principal amount hereof or any portion of such principal which is $1,000 or
a multiple thereof, into cash, shares of Common Stock or a combination thereof, at the Conversion
Rate specified in the Indenture. The initial Conversion Rate is 25.2207 shares of Common Stock per
$1,000 principal amount of Notes, subject to adjustment in certain events described in the
Indenture.

     Upon conversion, Holders will receive, at the Company’s election, cash, shares of Common Stock
or a combination thereof, as set forth in the Indenture. However, at any time prior to the 30th
Scheduled Trading Day preceding August 15, 2016, the Company may irrevocably make a Net Share
Settlement Election, which entitles the Company to pay an amount in cash equal to the Fixed Cash
Amount in respect to the Notes tendered for conversion, together with shares of Common Stock to the
extent that the Company’s payment obligations in respect of the Notes exceed such Fixed Cash
Amount.

     No fractional shares will be issued upon any conversion, but an adjustment and payment in cash
will be made, as provided in the Indenture, in respect of any fraction of a share which would
otherwise be issuable upon the surrender of any Notes for conversion. Notes in respect of which a
Holder is exercising its right to require repurchase on a Fundamental Change Repurchase Date may be
converted only if such Holder withdraws its election to exercise such right in accordance with the
terms of the Indenture;

     8. Denominations; Transfer; Exchange.

     The Notes are in registered form, without coupons, in denominations of $1,000 and multiples of
$1,000. A Holder may register the transfer of or exchange Notes in accordance with the Indenture.
The Registrar may require a Holder, among other things, to furnish appropriate endorsements and
transfer documents and to pay any taxes, assessments or other governmental charges that may be
imposed in relation thereto by law or permitted by the Indenture.

6

 

     9. Unclaimed Money or Securities.

     The Trustee and the Paying Agent shall return to the Company upon request any cash or
securities held by them for the payment of any amount with respect to the Notes that remains
unclaimed for two years, subject to applicable unclaimed property law. After return to the Company,
Holders entitled to the cash or securities must look to the Company for payment as general
creditors unless an applicable abandoned property law designates another Person.

     10. Amendment, Supplement and Waiver.

     Subject to certain exceptions, the Notes or the Indenture may be amended or supplemented with
the consent of the Holders of at least a majority in aggregate principal amount of the Notes then
outstanding, and subject to certain exceptions, an existing Default or Event of Default with
respect to the Notes and its consequence or compliance with any provision of the Notes or the
Indenture may be waived with the consent of the Holders of at least a majority in aggregate
principal amount of the Notes then outstanding. Without the consent of or notice to any Holder,
the Company and the Trustee may amend or supplement the Indenture or the Notes to, among other
things, cure any ambiguity, defect, manifest error, omission or inconsistency or make any change
that does not adversely affect the rights under the Indenture of any Holder of outstanding Notes.

     11. Defaults and Remedies.

     If any Event of Default other than as a result of certain events of bankruptcy, insolvency or
reorganization of the Company occurs and is continuing, the principal of all the Notes then
outstanding plus accrued and unpaid interest (including Additional Interest, if any), may be
declared due and payable in the manner and with the effect provided in the Indenture. If an Event
of Default occurs as a result of certain events of bankruptcy, insolvency or reorganization of the
Company, the principal amount of the Notes plus accrued and unpaid interest (including Additional
Interest, if any) shall become due and payable immediately without any declaration or other act on
the part of the Trustee or any Holder, all to the extent provided in the Indenture.

     12. Authentication.

     This Note shall not be valid until the Trustee or an authenticating agent manually signs the
certificate of authentication on this Note.

     13. Abbreviations.

     Customary abbreviations may be used in the name of the Holder or an assignee, such as: TEN
COM (= tenants in common), TEN ENT (= tenants by the entireties), JT TEN (= joint tenants with
right of survivorship and not as tenants in common), CUST (= Custodian) and UGMA (= Uniform Gifts
to Minors Act).

7

 

     14. Indenture to Control; Governing Law.

     To the extent permitted by applicable law, if any provision of this Note conflicts with the
express provisions of the Indenture, the provisions of the Indenture shall govern and be
controlling.

     This Note shall be governed by and construed in accordance with the laws of the state of New
York (without giving effect to the conflict of laws principles thereof).

8

 

SCHEDULE OF EXCHANGES OF NOTES2

     The following exchanges, purchases or conversions of a part of this Global Note have been
made:

	 	 	 	 	 	 	 	 	 
	 	 	Signature of	 	 	 	 	 	Principal Amount of
	 	 	Authorized	 	 	 	 	 	this Global Note
	 	 	Signatory of	 	Decrease in	 	Increase in	 	Following Such
	Date of Decrease or	 	Trustee or	 	Principal Amount of	 	Principal Amount of	 	Decrease or
	Increase	 	Custodian	 	this Global Note	 	this Global Note	 	Increase
	 	 	 	 	 	 	 	 	 

 

			
	2	 	This schedule is to be included only if the Note is a
Global Note.

9

 

ASSIGNMENT FORM

     If you want to assign this Note, fill in the form below and have your signature guaranteed:

     I or we assign and transfer this Note to:

      

 

 

(Print or type name, address and zip code and social security or tax ID number of assignee)

     and irrevocably appoint                                                              agent to transfer
 this Note on the books
of the Company. The agent may substitute another to act for him.

	 	 	 
	Date:                                         

	 	Signed:                                         
	 
	 	 
	(Sign exactly as your name appears on the other side of this Note)

	 	 	 
	Signature Guarantee:
	 	 
	 

	 	 

Note: Signatures must be guaranteed by an “eligible guarantor institution” meeting the
requirements of the Security Registrar, which requirements include membership or participation in
the Security Transfer Agent Medallion Program (“STAMP”) or such other “signature guarantee program”
as may be determined by the Security Registrar in addition to, or in substitution for, STAMP, all
in accordance with the Securities Exchange Act of 1934, as amended.

10

 

CONVERSION NOTICE

     If you want to exercise the option to convert this Note in accordance with the terms of the
Indenture referred to in this Note, check the box: o

     To convert only part of this Note, state the Principal Amount to be converted (which must be
$1,000 or a multiple of $1,000, provided that the portion not so converted is in a minimum
Principal Amount of $1,000):

     $                                                             

     If you want the share certificate, if any, made out in another person’s name, fill in the form
below:

      

(Insert other person’s social security or tax ID no.)

      

 

 

(Print or type other person’s name, address and zip code)

	 	 	 
	Date:                                         

	 	Signed:                                         
	 
	 	 
	(Sign exactly as your name appears on the other side of this Note)

	 	 	 
	Signature Guarantee:
	 	 
	 

	 	 

     Note: Signatures must be guaranteed by an “eligible guarantor institution” meeting the
requirements of the Security Registrar, which requirements include membership or participation in
the Security Transfer Agent Medallion Program (“STAMP”) or such other “signature guarantee program”
as may be determined by the Security Registrar in addition to, or in substitution for, STAMP, all
in accordance with the Securities Exchange Act of 1934, as amended.

11

 

FORM OF FUNDAMENTAL CHANGE REPURCHASE NOTICE

Wells Fargo Bank, National Association

MAC N9311-110

625 Marquette Avenue

Minneapolis, MN 55479

Attention: Corporate Trust Services

	 	Re:  	 	Onyx Pharmaceuticals, Inc. (the “Company”)

4.00% Convertible Senior Notes due 2016

     This is a Fundamental Change Repurchase Notice as defined in Section 4.01(a) of the Indenture,
dated as of August 12, 2009 (as amended, modified and supplemented by the First Supplemental
Indenture dated August 12, 2009, the “Indenture”) between the Company and Wells Fargo Bank,
National Association, as trustee (the “Trustee”). Terms used but not defined herein shall have the
meanings ascribed to them in the Indenture.

Certificate No(s). of Notes:                                         

     I intend to deliver the following aggregate principal amount of Notes for purchase by the
Company pursuant to Article 4 of the Indenture (multiples of $1,000 with a minimum of $1,000):

$

     I hereby agree that the Notes will be purchased on the Fundamental Change Repurchase Date
pursuant to the terms and conditions specified in the Notes and in the Indenture.

Signed:                                                             

12exv4w01

Exhibit 4.1

          This Note is a Global Security within the meaning of the Indenture hereinafter referred to and
is registered in the name of the Depository named below or a nominee of the Depository. This Note
is not exchangeable for Notes registered in the name of a Person other than the Depository or its
nominee except in the limited circumstances described herein and in the Indenture, and no transfer
of this Note (other than a transfer of this Note as a whole by the Depository to a nominee of the
Depository or by a nominee of the Depository to the Depository or another nominee of the
Depository) may be registered except in the limited circumstances described herein.

          Unless this certificate is presented by an authorized representative of The Depository Trust
Company, a New York corporation (the “Depository”), to the Company or its agent for registration of
transfer, exchange, or payment, and any certificate issued is registered in the name of Cede & Co.
or in such other name as is requested by an authorized representative of the Depository (and any
payment is made to Cede & Co. or to such other entity as is requested by an authorized
representative of the Depository), ANY TRANSFER, PLEDGE, OR OTHER USE HEREOF FOR VALUE OR OTHERWISE
BY OR TO ANY PERSON IS WRONGFUL inasmuch as the registered owner hereof, Cede & Co., has an
interest herein.

CITIGROUP INC.

6.375% Notes due August 12, 2014

			
	 	 	 
	REGISTERED
	 	REGISTERED
	 	 	 
	 
	 	CUSIP: 172967EY3

ISIN: US172967EY38

Common Code: 044577097
	 	 	 
	No. R-                     
	 	$                    

          CITIGROUP INC., a Delaware corporation (the “Company”, which term includes any successor
Person under the Indenture), for value received, hereby promises to pay to Cede & Co., or
registered assigns, the principal sum of $                     on August 12, 2014 and to pay interest
thereon from and including August 12, 2009 or from the most recent Interest Payment Date to which
interest has been paid or duly provided for, semi-annually, on February 12 and August 12 of each
year, commencing February 12, 2010 at the rate of 6.375% per annum, until the principal hereof is
paid or made available for payment. The interest so payable, and punctually paid or duly provided
for, on any Interest Payment Date will, as provided in the Indenture, be paid to the Person in
whose name this Note is registered at the close of business on the Record Date for such interest,
which shall be the February 1 and August 1 (whether or not a Business Day) immediately preceding
such Interest Payment Date.

 

 

          Any such interest not so punctually paid or duly provided for will forthwith cease to be
payable to the holder on such Record Date and may either be paid to the Person in whose name this
Note is registered at the close of business on a subsequent Record Date, such subsequent Record
Date to be not less than five days prior to the date of payment of such defaulted interest, notice
whereof shall be given to holders of Notes of this series not less than 15 days prior to such
subsequent Record Date, or be paid at any time in any other lawful manner not inconsistent with the
requirements of any securities exchange on which the Notes of this series may be listed, and upon
such notice as may be required by such exchange, all as more fully provided in the Indenture.

          Interest hereon will be calculated on the basis of a 360-day year comprised of twelve 30-day
months.

          If either an Interest Payment Date or the Maturity of the Notes falls on a day that is not a
Business Day, such Interest Payment Date or Maturity will be the next succeeding Business Day.
If a date for payment of interest or principal on the Notes falls on a day that is not a business
day in the place of payment, such payment will be made on the next succeeding business day in
such place of payment as if made on the date the payment was due. No interest will accrue on any
amounts payable for the period from and after the due date for payment of such principal or
interest.

          For these purposes, “Business Day” means any day which is a day on which commercial banks
settle payments and are open for general business in The City of New York.

          Payment of the principal of and interest on this Note will be made at the office or agency of
the Trustee maintained for that purpose in The City of New York.

          Reference is hereby made to the further provisions of this Note set forth on the reverse
hereof, which further provisions shall for all purposes have the same effect as if set forth at
this place.

          Unless the certificate of authentication hereon has been executed by the Trustee or by an
authenticating agent on behalf of the Trustee by manual signature, this Note shall not be entitled
to any benefit under the Indenture or be valid or obligatory for any purpose.

2

 

          IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed under its
corporate seal.

Dated: August 12, 2009

	 	 	 	 	 
	 	CITIGROUP INC.

 	 
	 	By:  	 	 
	 	Title:  Treasurer 	 

	 	 	 	 	 
	ATTEST:

 	 
	By:  	 	 
	Title:  Assistant Secretary 	 
	 	 	 	 

3

 

	 	 	 	 	 

     This is one of the Notes of the series issued under the within-mentioned Indenture.

Dated: August 12, 2009

	 	 	 	 	 
	 	THE BANK OF NEW YORK MELLON,

as Trustee

 	 
	 	By:  	 	 
	 	 	Name:  	 	 
	 	 	Title:  	 	 
	 
	 	-or-

CITIBANK, N.A.,

as Authenticating Agent

 	 
	 	By:  	 	 
	 	 	Name:  	 	 
	 	 	Title:  	 	 

4

 

	 	 	 	 	 

     This Note is one of a duly authorized issue of Securities of the Company (the “Notes”), issued
and to be issued in one or more series under the Indenture, dated as of March 15, 1987 (as amended
and supplemented to date, the “Indenture”), between the Company and The Bank of New York Mellon,
formerly known as The Bank of New York, as Trustee (the “Trustee”, which term includes any
successor trustee under the Indenture), to which Indenture and all indentures supplemental thereto
reference is hereby made for a statement of the respective rights, limitations of rights, duties
and immunities thereunder of the Company, the Trustee and the holders of the Notes and of the terms
upon which the Notes are, and are to be, authenticated and delivered. This Note is one of the
series designated on the face hereof, initially limited in aggregate principal to $2,500,000,000.

     If an event of default (as defined in the Indenture) with respect to Notes of this series
shall occur and be continuing, the principal of the Notes of this series may be declared due and
payable in the manner and with the effect provided in the Indenture.

     The Indenture contains provisions for defeasance at any time of the entire indebtedness of
this Note upon compliance by the Company with certain conditions set forth in Sections 11.03 and
11.04 thereof, which provisions apply to this Note.

     The Indenture contains provisions permitting the Company and the Trustee, without the consent
of the holders of the Securities, to establish, among other things, the form and terms of any
series of Securities issuable thereunder by one or more supplemental indentures, and, with the
consent of the holders of not less than 66 2/3% in aggregate principal amount of Securities at the
time outstanding which are affected thereby, to modify the Indenture or any supplemental indenture
or the rights of the holders of Securities of such series to be affected, provided that no such
modification will (i) extend the fixed maturity of any Securities, reduce the rate or extend the
time of payment of interest thereon, reduce the principal amount thereof or the premium, if any,
thereon, reduce the amount of the principal of Original Issue Discount Securities payable on any
date, change the currency in which Securities are payable, or impair the right to institute suit
for the enforcement of any such payment on or after the maturity thereof, without the consent of
the holder of each Security so affected, or (ii) reduce the aforesaid percentage of Securities of
any series the consent of the holders of which is required for any such modification without the
consent of the holders of all Securities of such series then outstanding, or (iii) modify, without
the written consent of the Trustee, the rights, duties or immunities of the Trustee.

     No reference herein to the Indenture and no provision of this Note or of the Indenture shall
alter or impair the obligation of the Company, which is absolute and unconditional, to pay the
principal of and interest on this Note at the times, place and rate, and in the coin or currency,
herein prescribed.

     This Note is a Global Security registered in the name of a nominee of the Depository. This
Note is exchangeable for Notes registered in the name of a person other than the Depository or its
nominee only in the limited circumstances hereinafter described. Unless and until it is exchanged
in whole or in part for definitive Notes in certificated form, this Note may not be

R-1

 

transferred except as a whole by the Depository to a nominee of the Depository or by a nominee of
the Depository to the Depository or another nominee of the Depository.

     The Notes represented by this Global Security are exchangeable for definitive Notes in
certificated form of like tenor as such Notes in denominations of $1,000 and whole multiples of
$1,000 in excess thereof only if (i) the Depository notifies the Company that it is unwilling or
unable to continue as Depository for the Notes or (ii) the Depository ceases to be a clearing
agency registered under the Securities Exchange Act of 1934, as amended, or (iii) the Company in
its sole discretion decides to allow the Notes to be exchanged for definitive Notes in registered
form. Any Notes that are exchangeable pursuant to the preceding sentence are exchangeable for
certificated Notes issuable in authorized denominations and registered in such names as the
Depository shall direct. As provided in the Indenture and subject to certain limitations therein
set forth, the transfer of definitive Notes in certificated form is registrable in the register
maintained by the Company in The City of New York for such purpose, upon surrender of the
definitive Note for registration of transfer at the office or agency of the registrar, duly
endorsed by, or accompanied by a written instrument of transfer in form satisfactory to the Company
and the registrar duly executed by, the holder thereof or his attorney duly authorized in writing,
and thereupon one or more new Notes of this series and of like tenor, of authorized denominations
and for the same aggregate principal amount, will be issued to the designated transferee or
transferees. Subject to the foregoing, this Note is not exchangeable, except for a Global Security
or Global Securities of this issue of the same principal amount to be registered in the name of the
Depository or its nominee.

     No service charge shall be made for any such registration of transfer or exchange, but the
Company may require payment of a sum sufficient to cover any tax or other governmental charge
payable in connection therewith.

     Prior to due presentment of this Note for registration of transfer, the Company, the Trustee
and any agent of the Company or the Trustee may treat the Person in whose name this Note is
registered as the owner hereof for all purposes, whether or not this Note be overdue, and neither
the Company, the Trustee nor any such agent shall be affected by notice to the contrary.

     The Company will pay additional amounts (“Additional Amounts”) to the beneficial owner of any
Note that is a non-United States person in order to ensure that every net payment on such Note will
not be less, due to payment of U.S. withholding tax, than the amount then due and payable. For
this purpose, a “net payment” on a Note means a payment by the Company or a paying agent, including
payment of principal and interest, after deduction for any present or future tax, assessment or
other governmental charge of the United States. These Additional Amounts will constitute additional
interest on the Note.

     The Company will not be required to pay Additional Amounts, however, in any of the
circumstances described in items (1) through (13) below.

	 	(1)	 	Additional Amounts will not be payable if a payment on a Note is reduced as a
result of any tax, assessment or other governmental charge that is imposed or withheld
solely by reason of the beneficial owner:

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	 	(a)	 	having a relationship with the United States as a citizen,
resident or otherwise;
	 
	 	(b)	 	having had such a relationship in the past or

	 
	 	(c)	 	being considered as having had such a relationship.

	 	(2)	 	Additional Amounts will not be payable if a payment on a Note is reduced as a
result of any tax, assessment or other governmental charge that is imposed or withheld
solely by reason of the beneficial owner:

	 	(a)	 	being treated as present in or engaged in a trade or business
in the United States;
	 
	 	(b)	 	being treated as having been present in or engaged in a trade
or business in the United States in the past or
	 
	 	(c)	 	having or having had a permanent establishment in the United
States.

	 	(3)	 	Additional Amounts will not be payable if a payment on a Note is reduced as a
result of any tax, assessment or other governmental charge that is imposed or withheld
in whole or in part by reason of the beneficial owner being or having been any of the
following (as such terms are defined in the Internal Revenue Code of 1986, as amended):

	 	(a)	 	personal holding company;
	 
	 	(b)	 	foreign personal holding company;
	 
	 	(c)	 	foreign private foundation or other foreign tax-exempt
organization;
	 
	 	(d)	 	passive foreign investment company;
	 
	 	(e)	 	controlled foreign corporation or
	 
	 	(f)	 	corporation which has accumulated earnings to avoid United
States federal income tax.

	 	(4)	 	Additional Amounts will not be payable if a payment on a Note is reduced as a
result of any tax, assessment or other governmental charge that is imposed or withheld
solely by reason of the beneficial owner owning or having owned, actually or
constructively, 10 percent or more of the total combined voting power of all classes of
stock of the Company entitled to vote or by reason of the beneficial owner being a bank
that has invested in a Note as an extension of credit in the ordinary course of its
trade or business.

For purposes of items (1) through (4) above, “beneficial owner” means a fiduciary, settlor,
beneficiary, member or shareholder of the holder if the holder is an estate, trust, partnership,
limited liability company, corporation or other entity, or a person holding a power over an estate
or trust administered by a fiduciary holder.

	 	(5)	 	Additional Amounts will not be payable to any beneficial owner of a Note that
is a:

	 	(a)	 	fiduciary;

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	 	(b)	 	partnership;
	 
	 	(c)	 	limited liability company or
	 
	 	(d)	 	other fiscally transparent entity

	 	 	 	or that is not the sole beneficial owner of the Note, or any portion of the Note.
However, this exception to the obligation to pay Additional Amounts will only apply
to the extent that a beneficiary or settlor in relation to the fiduciary, or a
beneficial owner or member of the partnership, limited liability company or other
fiscally transparent entity, would not have been entitled to the payment of an
Additional Amount had the beneficiary, settlor, beneficial owner or member received
directly its beneficial or distributive share of the payment.
	 
	 	(6)	 	Additional Amounts will not be payable if a payment on a Note is reduced as a
result of any tax, assessment or other governmental charge that is imposed or withheld
solely by reason of the failure of the beneficial owner or any other person to comply
with applicable certification, identification, documentation or other information
reporting requirements. This exception to the obligation to pay Additional Amounts will
only apply if compliance with such reporting requirements is required by statute or
regulation of the United States or by an applicable income tax treaty to which the
United States is a party as a precondition to exemption from such tax, assessment or
other governmental charge.
	 
	 	(7)	 	Additional Amounts will not be payable if a payment on a Note is reduced as a
result of any tax, assessment or other governmental charge that is collected or imposed
by any method other than by withholding from a payment on a Note by the Company or a
paying agent.
	 
	 	(8)	 	Additional Amounts will not be payable if a payment on a Note is reduced as a
result of any tax, assessment or other governmental charge that is imposed or withheld
by reason of a change in law, regulation, or administrative or judicial interpretation
that becomes effective more than 15 days after the payment becomes due or is duly
provided for, whichever occurs later.
	 
	 	(9)	 	Additional Amounts will not be payable if a payment on a Note is reduced as a
result of any tax, assessment or other governmental charge that is imposed or withheld
by reason of the presentation by the beneficial owner of a Note for payment more than
30 days after the date on which such payment becomes due or is duly provided for,
whichever occurs later.
	 
	 	(10)	 	Additional Amounts will not be payable if a payment on a Note is reduced as a
result of any:

	 	(a)	 	estate tax;
	 
	 	(b)	 	inheritance tax;
	 
	 	(c)	 	gift tax;
	 
	 	(d)	 	sales tax;

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	 	(e)	 	excise tax;
	 
	 	(f)	 	transfer tax;
	 
	 	(g)	 	wealth tax;
	 
	 	(h)	 	personal property tax or
	 
	 	(i)	 	any similar tax, assessment, withholding, deduction or other
governmental charge.

	 	(11)	 	Additional Amounts will not be payable if a payment on a Note is reduced as a
result of any tax, assessment, or other governmental charge required to be withheld by
any paying agent from a payment of principal or interest on a Note if such payment can
be made without such withholding by any other paying agent.
	 
	 	(12)	 	Additional amounts will not be payable if a payment on a Note is reduced as a
result of any tax, assessment or other governmental charge that is required to be made
pursuant to any European Union directive on the taxation of savings income or any law
implementing or complying with, or introduced to conform to, any such directive.
	 
	 	(13)	 	Additional Amounts will not be payable if a payment on a Note is reduced as a
result of any combination of items (1) through (12) above.

     Except as specifically provided herein, the Company will not be required to make any payment
of any tax, assessment or other governmental charge imposed by any government or a political
subdivision or taxing authority of such government.

     As used in this Note, “United States person” means:

	 	(a)	 	any individual who is a citizen or resident of the United States;
	 
	 	(b)	 	any corporation, partnership or other entity created or organized in or under
the laws of the United States;
	 
	 	(c)	 	any estate if the income of such estate falls within the federal income tax
jurisdiction of the United States regardless of the source of such income and
	 
	 	(d)	 	any trust if a United States court is able to exercise primary supervision over
its administration and one or more United States persons have the authority to control
all of the substantial decisions of the trust.

     Additionally, “non-United States person” means a person who is not a United States person, and
“United States” means the states of the United States of America and the District of Columbia, but
excluding its territories and its possessions.

     Except as provided below, the Notes may not be redeemed prior to maturity.

	 	(1)	 	The Company may, at its option, redeem the Notes if:

	 	(a)	 	the Company becomes or will become obligated to pay Additional
Amounts as described above;

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	 	(b)	 	the obligation to pay Additional Amounts arises as a result of
any change in the laws, regulations or rulings of the United States, or an
official position regarding the application or interpretation of such laws,
regulations or rulings, which change is announced or becomes effective on or
after August 5, 2009 and
	 
	 	(c)	 	the Company determines, in its business judgment, that the
obligation to pay such Additional Amounts cannot be avoided by the use of
reasonable measures available to it, other than substituting the obligor under
the Notes or taking any action that would entail a material cost to the
Company.

	 	(2)	 	The Company may also redeem the Notes, at its option, if:

	 	(a)	 	any act is taken by a taxing authority of the United States on
or after August 5, 2009, whether or not such act is taken in relation to the
Company or any affiliate, that results in a substantial probability that the
Company will or may be required to pay Additional Amounts as described above;
	 
	 	(b)	 	the Company determines, in its business judgment, that the
obligation to pay such Additional Amounts cannot be avoided by the use of
reasonable measures available to it, other than substituting the obligor under
the Notes or taking any action that would entail a material cost to the Company
and
	 
	 	(c)	 	the Company receives an opinion of independent counsel to the
effect that an act taken by a taxing authority of the United States results in
a substantial probability that the Company will or may be required to pay the
Additional Amounts described under above, and delivers to the Trustee a
certificate, signed by a duly authorized officer, stating that based on such
opinion the Company is entitled to redeem the Notes pursuant to their terms.

Any redemption of the Notes as set forth in clauses (1) or (2) above shall be in whole, and not in
part, and will be made at a redemption price equal to 100% of the principal amount of the Notes
Outstanding plus accrued interest thereon to the date of redemption. Holders shall be given not
less than 30 days nor more than 60 days prior notice by the Trustee of the date fixed for such
redemption.

     All terms used in this Note which are defined in the Indenture shall have the meanings
assigned to them in the Indenture. The Notes are governed by the laws of the State of New York.

R-6

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