Document:

Exhibit 4.27

 

DATED
                                     17
APRIL 2020

 

 

 

 

 

	MIDATECH PHARMA PLC	(1)
	 	 
	and	 
	 	 
	DR CRAIG COOK	(2)

 

 

 

 

 

 

	
     

    SETTLEMENT AGREEMENT 

WITHOUT PREJUDICE AND SUBJECT TO CONTRACT 
 

 

    	 		 

    	 

    

 

Table of Contents

 

 

 

	1.	Definitions and Interpretation	1
	2.	Termination	5
	3.	Compensation	5
	4.	Indemnity	5
	5.	Company Property	6
	6.	Settlement and Waiver	7
	7.	Confidentiality and Restrictive Covenants	8
	8.	Warranties	9
	9.	Legal Fees	11
	10.	Share Option Scheme	11
	11.	Management Incentive Scheme	12
	12.	Previous Termination Arrangements	12
	13.	Rights of Third Parties	12
	14.	Counterparts	12
	15.	Governing Law and Jurisdiction	12
	16.	General	13
	Schedule 1 Solicitor’s Certificate	14
	Schedule 2 Announcement	15
	Schedule 3 Handover Period Objectives	16
	Schedule 4 Management Incentive Scheme (“MIS”)	17
	Schedule 5 Letter of Resignation	20
	ATTESTATION CLAUSES	21

 

    	 		 

    	 

    

 

	THIS AGREEMENT is dated 	17 April 2020

 

PARTIES

 

		(1)	MIDATECH PHARMA PLC (company number 09216368) whose registered office is at 65 Innovation
Drive, Milton Park, Abingdon, Oxfordshire OX14 4RQ (the “Company”); and

 

		(2)	DR CRAIG COOK of Flat 4, 61 Inverness Terrace, London W2 3JT (the “Employee”).

 

OPERATIVE PROVISIONS

 

		1.	DEFINITIONS
                                         AND INTERPRETATION

 

		1.1	In this Agreement, except where a different interpretation is necessary in the context, the expressions
set out below shall have the following meanings:

 

	Adviser	as set out in clause 6.4
	 	 
	Agreement	this agreement and any schedules to this agreement as amended, modified or supplemented from time to time in accordance with the terms set out below
	 	 
	Certificate	the certificate set out in Schedule 1 to this Agreement
	 	 
	Confidential Information	all Information relating to:
	 	 
	 	(a)          the business or prospective business, current or projected plans or internal affairs of the Company, any Group Company, or any of its or their clients, customers, suppliers and agents, including in particular, all know-how, trade secrets, products, operations, processes, product information and unpublished information relating to the intellectual property rights of the Company, any Group Company, or any of its or their clients, customers, suppliers and agents;
	 	 
	 	(b)          any directors, officers, partners, members, agents, shareholders or employees (including, without limitation, details of terms and conditions of employment) of the Company or any Group Company; and
	 	 
	 	(c)      
    any other commercial, financial or technical information relating to the business or
    prospective business of the Company or any Group Company;
	 	 
	 	whether or not such Information is marked confidential and irrespective of when or how such Information was imparted or obtained
	 	 

 

    	 		 

    	 

    

 

	Contacts	any contacts which the Employee has stored or recorded (including without limitation on any hard drive, system, network, hand-held or other electronic devices, or any social media websites) during the course of his employment with the Company (unless obviously personal to the Employee and not related in any way to his employment with the Company)
	 	 
	Deductions	any income tax, employee’s national insurance contributions or any other sum that the Company is required to deduct at source by law, or otherwise entitled to deduct under the terms of this Agreement
	 	 
	Departure Date	30 April 2020        
	 	 
	Documents	documents, books, correspondence, files, statistics, papers, materials, reports, minutes, plans, records, surveys, diagrams, computer printouts, computer disks, CDs, audio tapes, manuals, customer documentation or other medium, whether or not eye-readable, on which Information (whether Confidential Information or otherwise) belonging to or relating to the Company or any Group Company and received or created by the Employee in the course of his employment may from time to time be contained, written or recorded (including without limitation on any social media websites), and all copies, drafts, reproductions, notes, extracts or summaries of such Information in whatever form
	 	 
	EMI Option Agreement 	share option agreement to be entered into between the company and the Employee incorporating the terms applicable to the new share options to be issued to the Employee under the Share Option Scheme
	 	 
	Group Company	the Company and its subsidiary undertakings from time to time and the ultimate parent undertaking (if any) of the Company from time to time and every other undertaking which from time to time is a subsidiary undertaking of the same ultimate parent undertaking (if any) (“parent undertaking” and “subsidiary undertaking” as defined by section 1162 and Schedule 7 and “undertaking” as defined by section 1161 of the Companies Act 2006), or an associated company as defined by section 449 Corporation Tax Act 2010
	 	 
	Information	information whether in tangible or any other form, including specifications, reports, data, notes, documentation, drawings, software, computer outputs, designs, circuit diagrams, models, patterns, samples, inventions (whether capable of being patented or not) and know-how, and the media (if any) upon which such information is supplied
	 	 

 

    	 	2	 

    	 

    

 

	Pre-Contractual 

Statement	any undertaking, promise, assurance, statement, representation, warranty or understanding (whether written, oral, or governed by a course of dealings) of any person (whether party to this Agreement or not) relating to the employment of the Employee and its termination, which is not expressly set out in this Agreement
	 	 
	Protected Disclosure	a qualifying disclosure as defined by section 43B Employment Rights Act 1996 (“ERA”), which is made by the Employee in accordance with any of sections 43C to 43H ERA
	 	 
	Service Agreement	contract of employment between the Employee and the Company dated 1 June 2018
	 	 
	Settlement Sum	as set out in clause 3.1
	 	 
	Share Option Scheme  	the Midatech Pharma PLC Enterprise Management Incentive Scheme adopted in December 2014
	 	 
	 	 
	 	 
	Statutory Claims	the claims the Employee has or may have against the Company or any Group Company and/or its or their directors, officers, partners, members, employees, professional advisers, agents, and/or shareholders, for breaches of:
	 	 
	 	·             the Employment Rights Act 1996, including (but not limited to) claims of actual or constructive unfair dismissal, unlawful deductions from wages or unauthorised payments, claims arising from the making of a Protected Disclosure, detrimental treatment, rights to time off work, claims in relation to section 1 particulars, in relation to written reasons for dismissal and any other claims referred to in the Employment Tribunals Act 1996
	 	 
	 	·             the Employment Relations Act 1999, including (but not limited to) claims in relation to the right to be accompanied and detriment in relation to this right
	 	 
	 	·             the Working Time Regulations 1998, including (but not limited to) claims relating to working time and/or holiday pay
	 	 
	 	·             the Protection from Harassment Act 1997, including (but not limited to) claims of harassment
	 	 

 

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	 	·             the Equality Act 2010, including (but not limited to):
	 	 
	 	·             claims for equality of terms, of instructing, causing, inducing or aiding contraventions, of direct or indirect discrimination, victimisation or harassment, because of, or in relation to, sex, marriage or civil partnership
	 	 
	 	
        ·             claims
        of instructing, causing, inducing or aiding contraventions, of direct or indirect discrimination, victimisation or harassment,
        because of, or in relation to, race, colour, nationality, ethnic or national origin

        ·             claims
        of instructing, causing, inducing or aiding contraventions, of direct or indirect discrimination, discrimination arising in consequence
        of a disability, victimisation or harassment, because of, or in relation to, disability and/or in relation to any alleged failure
        to make adjustments

	 	
	 	·             claims of instructing, causing, inducing or aiding contraventions, of direct or indirect discrimination, victimisation or harassment, because of, or in relation to age
	 	
	 	·             claims of instructing, causing, inducing or aiding contraventions, of direct or indirect discrimination, victimisation or harassment, because of, or in relation to, religion or belief; and
	 	
	 	and breaches of the Employee’s rights and/or the Company’s (or any Group Company’s) obligations under the provisions of the legislation mentioned above, whether in existence as at the date of this Agreement or arising in the future because of facts subsequently coming to light or changes to the law
	 	 
	Statute	the Acts and Regulations referred to in the definition of Statutory Claims above

 

		1.2	References to the word “include” or “including” (or any similar
term) are not to be construed as implying any limitation and general words introduced by the word “other” (or
any similar term) shall not be given a restrictive meaning by reason of the fact that they are preceded or followed by words indicating
a particular class of acts, matters or things.

 

		1.3	References to any Statute or other enactment are to be construed as referring also to any enactment
of, re-enactment of, extension to, or amendment to it (whether before or after the date of this Agreement), and to any previous
enactment which such Statute or enactment has replaced (with or without amendment) and to any regulation, order, statutory instrument,
or subordinate legislation made under such enactment.

 

    	 	4	 

    	 

    

 

		2.	TERMINATION

 

		2.1	The appointment of the Employee as a director and Chief Executive Officer of the Company in accordance
with the terms of the Service Agreement terminated with immediate effect on 31 March 2020. The parties have agreed to vary the
terms of the Service Agreement, with retrospective effect from 31 March 2020, so that the notice period at clause 2.1 of the Service
Agreement shall be reduced from six months to one month and that, in accordance with the terms of clauses 2.2 and 3.3 (a) of this
Agreement, with effect from 1 April and continuing to 30 April 2020 ("Handover Period"), the Employee shall work
out that one month notice period, to enable the Employee, as a temporary measure, and on a reduced salary, to complete a handover
of his duties to Stephen Stamp, his successor Chief Executive Officer, in accordance with the terms of this Agreement. The Handover
Period and the employment of the Employee with the Company will terminate on one month's notice with immediate effect on the Departure
Date.

 

		2.2	From the date of this Agreement up until 30 April 2020, the Employee agrees that he will co-operate
fully with the board of the Company to ensure the smooth handover of his duties to Stephen Stamp. The Employee will be available
during the Company's normal business hours to undertake any such duties as the Company may require and the Employee will undertake
such duties, as more particularly described but not limited to the duties listed at Schedule 3, for not less than 25 hours a week
during the Handover Period.

 

		2.3	The Employee shall not hold himself out or conduct himself as a director of the Company, or any
Group Company after 31 March 2020, or as an employee of the Company, or any Group Company after the Departure Date.

 

		2.4	The Company will pay the Employee's outstanding salary and an agreed payment of £3,500 gross
(less Deductions) in lieu of accrued but untaken holiday entitlement accrued up to the Departure Date within 14 days of the Departure
Date.

 

		2.5	Save as otherwise provided by this Agreement, the Employee’s contractual benefits provided
by the Company ceased on 31 March 2020.

 

		2.6	As soon as practicable after the Departure Date the Company will issue the Employee’s P45.

 

		2.7	The Company announced the Employee’s resignation as a Director and Chief Executive Officer
on 31 March 2020 in the terms set out in Schedule 2.

 

		2.8	The Employee will immediately provide the Company with his written resignation from the offices
which the Employee held in the Company or any other company and all other appointments, trusteeships, memberships and positions
which he held as nominee or representative of the Company with effect from 31 March 2020 in the form attached at Schedule 5 to
this Agreement.

 

		3.	COMPENSATION

 

		3.1	Subject to the further provisions of this clause 3, in connection with the termination of the Employee’s
employment and subject to and conditional on the Employee complying and continuing to comply fully with the terms of this Agreement,
the Company shall pay the Employee without admission of liability the total gross sum of £40,000.00 (the “Settlement
Sum”) less any Deductions.

 

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		3.2	The Settlement Sum, less any Deductions, shall be paid into the Employee’s nominated bank
account within 14 days of the latest of the dates on which the following has occurred:

 

		(a)	receipt by the Company’s solicitors of an original version of this Agreement duly executed
by the Employee, and the Certificate signed by the Adviser; and

 

		(b)	the return of the Company’s property in accordance with clause 5 below.

 

		3.3	The Settlement Sum comprises the following:

 

		(a)	£10,000.00 (gross) as payment for the Employee's duties during the Handover Period in accordance
with clause 2.2 of this Agreement (“Reduced Salary Payment”); and

 

		(b)	£30,000.00 (gross) paid as compensation to the Employee for the loss of his employment (“Compensatory
Payment”).

 

		3.4	The Settlement Sum will be paid less any Deductions. Specifically, the parties agree that the Company
will make deductions at source for any income tax and employee’s national insurance contributions which may be required in
respect of the Reduced Salary Payment.

 

		3.5	The parties agree that the amount of the Reduced Salary Payment is equal to the amount given by
the formula in section 402D (1) of Income Tax (Earnings and Pensions) Act 2003 ("ITEPA") and that, accordingly, the Employee's
Post-Employment Notice Pay (as defined by ITEPA) is nil.

 

		3.6	Accordingly, the parties' understanding is that no part of the Compensatory Payment is taxable
as Post-Employment Notice Pay.

 

		3.7	The Compensatory Payment will be paid tax free, as a termination award under the threshold within
the meaning of sections 402A(1) and 403 of ITEPA.

 

		3.8	The parties agree that the Settlement Sum is made in good faith and that the Compensatory Payment
is paid by way of settlement or compromise of any claim arising in connection with the termination of the Employee’s offices
and employment.

 

		4.	INDEMNITY

 

		4.1	The Employee agrees that he is wholly liable for the amount of any tax (including without limitation,
income tax and employee’s national insurance contributions), arising in connection with the Settlement Sum or any other payments
or arrangements set out in this Agreement, other than any deductions for tax or employee’s national insurance contributions
made at source by the Company pursuant to clause 3.4 or otherwise.

 

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		4.2	The Employee agrees fully and properly to indemnify and keep indemnified the Company or any Group
Company against any demand for tax (including, without limitation, income tax and employee’s national insurance contributions)
which may become payable arising from his employment, the Settlement Sum or any other payments or arrangements set out in this
Agreement or arising in connection with the termination of his employment with the Company and any interest, penalties, costs,
claims, damages or other expenses which the Company or any Group Company may incur in this regard (save for any liability which
arises solely as a result of the default or delay of the Company, or any Group Company), including, without limitation, as a result
of challenging such demand for tax provided that the Company may choose (in its sole discretion) to challenge any such demand following
receipt of a reasonable written request from the Employee, and in the absence of such a request, the Company, or any Group Company,
may challenge such tax demand or comply with any such tax demand (in its sole discretion) and, the Employee shall be liable to
the Company, or any Group Company, under this indemnity or in relation to any such tax demand (including any liability resulting
from a failure to deduct tax).

 

		4.3	For the avoidance of doubt:

 

		(a)	the indemnity in clause 4.2 shall not apply to any tax or national insurance contributions which
have already been deducted at source by the Company under clause 3.4 or otherwise; and

 

		(b)	the indemnity in clause 4.2 shall extend to any income tax or employee’s national insurance
contributions, penalties and interest in respect of such arising on the Settlement Sum if HM Revenue & Customs do not accept
the parties’ agreed treatment of the constituent parts of the Settlement Sum as taxable only under sections 401 and 403 Income
Tax (Earnings and Pensions) Act 2003 or any other tax treatment of any other payment under this Agreement.

 

		5.	COMPANY
                                         PROPERTY

 

		5.1	Subject to clause 5.2, the Employee agrees to return, within seven days of the Departure Date,
in good condition and without modification all property (including but not limited to Documents, Confidential Information (and
any copies or reproductions of it), Contacts, , credit or charge cards, personal computer or laptop, keys, security passes) belonging
to the Company or any Group Company or relating to the business of the Company or any Group Company or any director, officer, partner,
member, shareholder, employee, client, customer, supplier, banker, agent or professional adviser of the Company or any Group Company
which is in the Employee’s possession or under his control.

 

		5.2	Subject to the further provisions of this clause 5, the Company will transfer to the Employee on
the Departure Date the mobile phone previously used by the Employee in the performance of his duties under the Service Agreement,
provided that the Employee shall take over the mobile phone contract with the service provider with effect from the Departure Date
and be responsible for all call and other charges in relation to the mobile phone with effect from the Departure Date. The Employee
further agrees that he shall redirect to the Company any calls regarding the Company received by him on the mobile phone following
the Departure Date at no cost to the Company.

 

		5.3	The Employee shall by no later than the Departure Date :

 

		(a)	inform the Company in writing of the passwords used by him on all computers, laptops or other electronic
devices which are the property of the Company or any Group Company; and

 

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		(b)	delete irretrievably from his mobile phone and personal computer (including from the hard drive)
and from any other computers, devices, systems or networks in his possession or control all and any Documents, Contacts and Information
(including but not limited to Confidential Information) (and any copies or reproductions of such) belonging to, or prepared for,
or obtained from, or relating to the business of, the Company, or any Group Company or any of its or their clients, customers,
suppliers and agents which may remain in existence notwithstanding the Employee’s compliance with clause 5.1.

 

		5.4	The Employee shall, if requested to do so by the Company, provide a signed statement that he has
complied fully with his obligations under clauses 5.1, 5.3 and 5.3 and shall provide the Company with such reasonable evidence
of compliance as may be requested.

 

		6.	SETTLEMENT
                                         AND WAIVER

 

		6.1	The Employee agrees to accept the arrangements contained in this Agreement and any sums paid under
its terms in full and final settlement of, and unconditionally and irrevocably waives, any and all present and future claims, rights
of action, remedies, awards, damages, costs, fees and expenses however arising which he has or may have in any jurisdiction against
the Company, any Group Company or any of its or their directors, officers, partners, members, employees, professional advisers,
agents or shareholders arising directly or indirectly from or in connection with his employment with the Company and/or its termination
or loss of any office, or any pre-termination negotiations or discussions in relation to the termination of employment, or any
rights he has or may have under any existing or proposed bonus or incentive scheme or arrangement, or any pension provision, or
Company pension contributions, or any other matter including any common law or statutory claims whether under English law, European
law, any of the Statutes, or any other applicable law such as (but not limited to) compensation for breach of contract, wrongful
dismissal, personal injury and any and all of the Statutory Claims. To the extent that such claims against the Company, any Group
Company, or any of its or their directors, officers, partners, or members, employees, professional advisers, agents or shareholders,
either do not exist at present, or cannot be identified by one or both parties, the Employee acknowledges that they may at some
future date arise or be identified, either because of facts coming to light or because of changes to the law, and agrees
to unconditionally and irrevocably waive all and any such claims.

 

		6.2	The waiver in clause 6.1 above shall not affect the following:

 

		(a)	any claim for personal injury, the symptoms of which have not manifested themselves at the date
of this Agreement; or

 

		(b)	any breach of contract claim arising from an actual or alleged breach of the terms of this Agreement;

 

although no admission of liability
is made by the Company in relation to any such claims and the Employee warrants that, as at the date of this Agreement, he is not
aware of any such claims or any facts or circumstances that may give rise to any such claims.

 

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		6.3	The Employee warrants that he:

 

		(a)	will refrain from instituting or continuing and will immediately and unconditionally withdraw,
in writing, any legal proceedings of any nature to or before any Employment Tribunal or court in relation to any claim referred
to in clause 6.1 and agrees that if any such proceedings are instituted or continued by him, or if he takes the benefit of any
proceedings which may be commenced on his behalf, and that if not repaid to the Company pursuant to clause 8.2, the Settlement
Sum paid to him will be accepted by him as being made on account of and applied towards any basic, compensatory, or any other award
or damages or fees or costs or expenses award which may be made in his favour;

 

		(b)	shall not make any subject access request (pursuant to the provisions of the Data Protection Act
2018 or the General Data Protection Regulation (EU) 2016/679) after the date of this agreement (in relation to matters of which
he was or ought reasonably to have been aware at the date of this agreement) and any subject access request made before the date
of this agreement shall be treated as immediately and unconditionally withdrawn.

 

		6.4	The Employee warrants and agrees that, before entering into this Agreement, he has received independent
legal advice as to the terms and effect of this Agreement and in particular as to its effect on his ability to pursue his rights,
complaints and claims (including in particular the Statutory Claims) before an Employment Tribunal from Peggy Barnard of Barnard
& Webb Solicitors, who is a relevant independent adviser as may be defined or referred to in each relevant Statute and who
held appropriate insurance or an appropriate indemnity (as may be defined or referred to in each relevant Statute) on the date
that such advice was given (the “Adviser”).

 

		6.5	The Employee will procure that the Adviser will complete the Certificate immediately following
the Employee’s execution of this Agreement, and promptly deliver the completed certificate to the Company’s solicitors.

 

		6.6	The conditions regulating compromise agreements and/or settlement agreements under or referred
to in each Statute are satisfied. In particular, but without limitation, the conditions set out in section 147(3)(c) and (d) of
the Equality Act 2010 are met.

 

		7.	CONFIDENTIALITY
                                         AND RESTRICTIVE COVENANTS

 

		7.1	The Employee undertakes and agrees to honour and abide by the confidentiality and restrictive covenant
provisions in the Service Agreement which shall therefore be binding on the Employee after the Departure Date as if they were repeated
in full in this Agreement. The terms used in those provisions shall have the meanings given to them in the Service Agreement.

 

		7.2	The Employee undertakes that except as required by law he will not at any time in the future, directly
or indirectly, without the prior written consent of the Company:

 

		(a)	disclose to any person the existence or fact or contents of this Agreement, or the terms of settlement
with the Company except to his professional advisers, HM Revenue & Customs and his spouse provided that disclosure to professional
advisers and spouse shall be on the condition that they agree to honour this obligation save that the Employee may notify potential
employers in any job interviews of the terms of clause 2.1 and the announcement at Schedule 2;

 

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		(b)	make or publish any public announcement, statement or comment whether in writing or otherwise concerning
the Company, any Group Company or any of its or their current or former directors, officers, partners, members, shareholders or
employees relating to her employment and/or termination of employment by the Company other than in the terms of the announcement
at Schedule 2; or

 

		(c)	make or publish any derogatory, disparaging, false, or misleading statements or comments concerning
the Company, any Group Company or any of its or their current or former directors, officers, partners, members, shareholders or
employees.

 

		7.3	The Company undertakes that, save as may be required by law, or to fulfil, establish, exercise,
or defend, any legal right or obligation, or any accounting, or regulatory obligation, of the Company (or any Group Company), or
to HM Revenue & Customs, or its professional advisers (having instructed them to honour the provisions of this clause), or
in respect of any matter in the public domain otherwise than in breach of this clause, it will not instruct or authorise any of
its current directors, officers, or employees to, directly or indirectly, without the prior written consent of the Employee:

 

		(a)	disclose to any person the contents of this Agreement, or the terms of settlement with the Employee;

 

		(b)	make or publish any public announcement, statement or comment relating to the Employee’s
employment and/or termination of employment other than in the terms of the announcement at Schedule 2; and

 

		(c)	make or publish any derogatory, disparaging, false, or misleading statements or comments concerning
the Employee.

 

		7.4	The Employee agrees that if the Company becomes aware that he has breached any of his obligations
under clauses 7.1, and 7.2 of this Agreement, on or after the Settlement Sum has been paid to him he will immediately repay all
of such sums to the Company.

 

		7.5	The Company’s right to repayment of the sums in accordance with clause 7.4 of this Agreement
shall be without prejudice to its right to seek an injunction against or claim further damages or account of profits from the Employee.

 

		7.6	For the avoidance of any doubt, all of the Employee’s obligations under clauses 2.3, 7.1,
and 7.2 above apply including without limitation to any activities by the Employee in relation to any social media websites.

 

		7.7	Nothing in this clause 7 shall prevent the Employee from making a Protected Disclosure.

 

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		8.	WARRANTIES

 

		8.1	The Employee represents and warrants to the Company as a strict condition of this Agreement and
in particular, payment of the Settlement Sum pursuant to clause 3.1 that:

 

		(a)	as at the date of this Agreement or the Departure Date, whichever is the later, there have been
no acts, omissions or defaults by him of which he is aware, or ought reasonably to be aware, which constitute a breach of his duties
as an employee of the Company;

 

		(b)	as at 31 March 2020 he has not received (either orally or in writing), nor agreed to accept (either
orally or in writing) any offer, conditional or unconditional, temporary or permanent, of a contract of service or for services,
or any association with a partnership, or to hold any office, or of any form of deferred remuneration to take effect at any time
after the Departure Date;

 

		(c)	before entering into this Agreement, he has raised with the Adviser all facts and issues relevant
to his employment and its termination which have given rise to, or could give rise to, a claim, whether under common law, statute,
or otherwise;

 

		(d)	he has taken advice from the Adviser in relation to the claims referred to in clause 6.1 (including,
without limitation, the Statutory Claims) and the terms and effect of this Agreement on his ability to pursue such rights, complaints
and claims as he may have against the Company, any Group Company or its or their employees, partners, directors, officers, members,
or shareholders; and

 

		(e)	following the receipt of the advice given to him by the Adviser in relation to the termination
of his employment, he is not aware of any other rights, complaints or claims (whether under common law, any Statute or statute,
or otherwise) he may have in relation to his employment by the Company or its termination other than the Statutory Claims.

 

		8.2	The Company enters into this Agreement in reliance upon the warranties given by the Employee in
clauses 6.1 to 6.4 and 8. In the event of any breach of any of these warranties, the Settlement Sum shall become immediately repayable
to the Company and shall be recoverable by the Company as a debt.

 

		8.3	In addition to the rights and remedies of the Company referred to in clause 6.3(a) and 8.2, in
the event of a breach of clauses 6.3(a), and/or 6.4 above, the Employee undertakes to indemnify the Company against any claims,
losses, costs (including legal costs), fees, awards, damages, liabilities or expenses which the Company may suffer or incur in
connection with any such allegation or breach.

 

		8.4	Any failure or delay of the Company, or any Group Company, to insist upon or enforce any right,
remedy or power conferred on it by this Agreement shall not be construed as a waiver of any such right, remedy or power.

 

		9.	LEGAL
                                         FEES

 

The Company will pay direct
to the Adviser within 30 days of receipt of a satisfactory copy of their invoice to the Employee, their fees and disbursements
properly, reasonably and exclusively incurred in advising the Employee in relation to the termination of his employment (including,
without limitation, the negotiation and preparation of this Agreement up to a maximum of £500.00 plus VAT.

 

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		10.	SHARE
                                         OPTION SCHEME

 

The Company
will grant the Employee 100,000 new share options under the Share Option Scheme. The new share options may be exercised in accordance
with the terms of the EMI Option Agreement. Any existing share options previously granted to the Employee under the Share Option
Scheme will lapse upon his ceasing to be an Employee on the Departure Date.

 

		11.	MANAGEMENT
                                         INCENTIVE SCHEME

 

The Employee will continue
to be able to participate in the Company's Management Incentive Scheme in accordance with the terms of that Management Incentive
Scheme, the terms of which are attached at Schedule 4.

 

		12.	PREVIOUS
                                         TERMINATION ARRANGEMENTS

 

The parties acknowledge and
agree that this Agreement and any document referred to in it constitute the entire agreement and understanding between the Employee
and the Company, in relation to the Employee’s employment with the Company and/or any Group Company and the termination of
such employment and supersedes all previous drafts, agreements, arrangements and understandings between the Employee and the Company,
and/or the Employee and any Group Company, and/or any related person (if any and whether written or oral or governed by a course
of dealings) in relation to the Employee’s employment and its termination, which shall terminate with effect from the later
of execution of this Agreement or the Departure Date; and in entering into this Agreement the Employee has not relied on any Pre-Contractual
Statement and the Employee shall have no remedy in respect of any Pre-Contractual Statement, although (without admission of liability
by the Company or any Group Company) nothing in this Agreement shall limit or exclude any liability for fraud.

 

		13.	RIGHTS
                                         OF THIRD PARTIES

 

Except in relation to any Group
Companies, this Agreement does not confer any rights on any person or party (other than the parties to this Agreement) under the
Contracts (Rights of Third Parties) Act 1999. The terms of this Agreement may be varied, or this Agreement may be suspended, cancelled
or terminated, by agreement in writing between the parties, without the consent of any third party.

 

		14.	COUNTERPARTS

 

This Agreement may be executed
in any number of counterparts, each of which shall be an original, and all the counterparts together shall constitute one and the
same agreement.

 

		15.	GOVERNING
                                         LAW AND JURISDICTION

 

This Agreement and any dispute
or claim arising out of or in connection with it tor its subject matter, whether of a contractual or non-contractual nature, is
governed by and construed in all respects in accordance with the law of England and Wales. The parties irrevocably agree that
the Courts of England and Wales shall have exclusive jurisdiction to settle any dispute arising out of or in connection with this
Agreement.

 

    	 	12	 

    	 

    

 

		16.	GENERAL

 

This Agreement, although marked
without prejudice and subject to contract” will, upon signature by both parties, be treated as an open document evidencing
an agreement binding on the parties.

 

This Agreement is executed as a deed by
the parties and is delivered and takes effect on the date at the beginning of this Agreement.

 

    	 	13	 

    	 

    

  

ATTESTATION
CLAUSES

 

	Signed by MIDATECH PHARMA PLC

acting by:
	 
	 
	/s/ Stephen Stamp	 	 
	[signature of director]	 	 
	 	 	 
	 	 	 
	 Stephen Stamp	 	 
	[print name of director]	 	 
	 	 	 
	Director	 	 

 

 

 

	Signed by DR CRAIG COOK
	 
	 
	 /s/ Dr. Craig Cook
	[signature]
	 
	 
	Dr. Craig Cook
	[print name of signatory]

 

 

14Exhibit
4.12

 

THESE
SECURITIES WERE ISSUED IN AN OFFSHORE TRANSACTION TO PERSONS WHO ARE NOT U.S. PERSONS (AS DEFINED HEREIN) PURSUANT TO REGULATIONS
UNDER THE UNITED STATES SECURITIES ACT OF 1933, AS AMENDED (THE “1933 ACT”). ACCORDINGLY, NONE OF THE SECURITIES TO
WHICH THIS CERTIFICATE RELATES NOR THE SECURITIES INTO WHICH THESE SECURITIES ARE CONVERTIBLE HAVE BEEN REGISTERED UNDER THE 1933
ACT, OR ANY U.S. STATE SECURITIES LAWS, AND, UNLESS SO REGISTERED, NONE MAY BE OFFERED OR SOLD IN THE UNITED STATES (AS DEFINED
HEREIN OR, DIRECTLY OR INDIRECTLY, TO U.S. PERSONS (AS DEFINED HEREIN) EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT
OR PURSUANT TO AN EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE 1933 ACT AND IN EACH
CASE ONLY IN ACCORDANCE WITH APPLICABLE STATE SECURITIES LAWS. IN ADDITION, HEDGING TRANSACTIONS INVOLVING THE SECURITIES MAY
NOT BE CONDUCTED UNLESS IN ACCORDANCE WITH THE 1933 ACT. “UNITED STATES” AND “U.S. PERSON” ARE AS DEFINED
BY REGULATION S UNDER THE 1933 ACT. ANY TRANSFEREE OF THIS NOTE SHOULD CAREFULLY REVIEW THE TERMS OF THIS NOTE.

 

US
$375,000.00 

 

TODOS
MEDICAL LTD.

2%
CONVERTIBLE REDEEMABLE NOTE

DUE
June 15, 2021

 

FOR
VALUE RECEIVED, Todos Medical Ltd. (the “Company”) promises to pay to the order of SHMUEL ROTBARD and its authorized
successors and permitted assigns (“Holder”), the aggregate principal face amount of Three Hundred Seventy Five
Thousand Dollars exactly (U.S. $375,000.00) on June 15, 2021 (“Maturity Date”) and to pay interest on the principal
amount outstanding hereunder at the rate of 2% per annum commencing on June 15, 2020 (“Issuance Date”). This
Note shall contain an original issue discount of $60,000 such that the purchase price of this Note shall be $315,000. The interest
will be paid to the Holder in whose name this Note is registered on the records of the Company regarding registration and transfers
of this Note. The principal of, and interest on, this Note are payable at Diskin 13/137, Jerusalem, Israel, initially, and if
changed, last appearing on the records of the Company as designated in writing by the Holder hereof from time to time. The Company
will pay each interest payment and the outstanding principal due upon this Note before or on the Maturity Date, less any amounts
required by law to be deducted or withheld, to the Holder of this Note by check or wire transfer addressed to such Holder at the
last address appearing on the records of the Company. The forwarding of such check or wire transfer shall constitute a payment
of outstanding principal hereunder and shall satisfy and discharge the liability for principal on this Note to the extent of the
sum represented by such check or wire transfer. Interest shall be payable in Common Stock (as defined below) pursuant to paragraph
4(b) herein.

 

    	 

    	 

    

 

This
Note is subject to the following additional provisions:

 

1.
This Note is exchangeable for an equal aggregate principal amount of Notes of different authorized denominations, as requested
by the Holder surrendering the same. No service charge will be made for such registration or transfer or exchange, except that
Holder shall pay any tax or other governmental charges payable in connection therewith.

 

2.
The Company shall be entitled to withhold from all payments any amounts required to be withheld under applicable laws.

 

3.
This Note may be transferred or exchanged only in compliance with the Securities Act of 1933, as amended (“Act”)
and applicable state securities laws. Any attempted transfer to a non-qualifying party shall be treated by the Company as void.
Prior to due presentment for transfer of this Note, the Company and any agent of the Company may treat the person in whose name
this Note is duly registered on the Company’s records as the owner hereof for all other purposes, whether or not this Note
be overdue, and neither the Company nor any such agent shall be affected or bound by notice to the contrary. Any Holder of this
Note electing to exercise the right of conversion set forth in Section 4(a) hereof, in addition to the requirements set forth
in Section 4(a), and any prospective transferee of this Note, also is required to give the Company written confirmation that this
Note is being converted (“Notice of Conversion”) in the form annexed hereto as Exhibit A. The date of
receipt (including receipt by telecopy) of such Notice of Conversion shall be the Conversion Date.

 

4.
(a) The Holder of this Note is entitled, at its option, at any time, to convert all or any amount of the principal face amount
of this Note then outstanding into shares of the Company’s common stock (the “Common Stock”) at a price
(“Conversion Price”) for each share of Common Stock equal to 80% of the lower of (i) the
lowest closing bid price the day prior to the Issuance Date or (ii) the lowest trading price of the
Common Stock as reported by the trading market on which the Company’s shares are traded, for the twenty
prior trading days including the day upon which a Notice of Conversion is received by the Company or its transfer agent (provided
such Notice of Conversion is delivered by fax or other electronic method of communication to the Company or its transfer agent
after 4 P.M. Eastern Standard or Daylight Savings Time if the Holder wishes to include the same day closing price). If the shares
have not been delivered within 3 business days, the Notice of Conversion may be rescinded. Such conversion shall be effectuated
by the Company delivering the shares of Common Stock to the Holder within 3 business days of receipt by the Company of the Notice
of Conversion. Accrued but unpaid interest shall be subject to conversion. No fractional shares or scrip representing fractions
of shares will be issued on conversion, but the number of shares issuable shall be rounded to the nearest whole share.
To the extent the Conversion Price of the Company’s Common Stock closes below the par value per share, the Company will
take all steps necessary to solicit the consent of the stockholders to reduce the par value to the lowest value possible under
law. The Company agrees to honor all conversions submitted pending this increase. In the event the Company experiences a DTC
“Chill” on its shares, the Conversion Price shall be decreased to 45% instead of 55% while that “Chill”
is in effect In no event shall the Holder be allowed to effect a conversion if such conversion, along with all other shares
of Company Common Stock beneficially owned by the Holder and its affiliates would exceed 4.99% of the outstanding shares of the
Common Stock of the Company (which may be increased up to 9.9% upon 60 days’ prior written notice by the Holder). The conversion
discount, look back period and other terms will be adjusted on a ratchet basis if the Company offers a more favorable conversion
discount, interest rate, (whether through a straight discount or in combination with an original issue discount), look back period
or other more favorable term to another party for any financings while this Note is in effect.

 

    	2

    	 

    

 

(b)
Interest on any unpaid principal balance of this Note shall be paid at the rate of 2% per annum. Interest shall be paid by the
Company in Common Stock (“Interest Shares”). Holder may, at any time, send in a Notice of Conversion to the Company
for Interest Shares based on the formula provided in Section 4(a) above. The dollar amount converted into Interest Shares shall
be all or a portion of the accrued interest calculated on the unpaid principal balance of this Note to the date of such notice.

 

(c)
The Notes may be prepaid with the following penalties:

 

	PREPAY
    DATE	 	PREPAY
    AMOUNT
	≤
    40 days	 	125%
    of principal plus accrued interest

 

This
Note may not be prepaid after the 40th day. Such redemption must be closed and funded within 3 days of giving notice
of redemption of the right to redeem shall be null and void.

 

(d)
Upon (i) a transfer of all or substantially all of the assets of the Company to any person in a single transaction or series of
related transactions, (ii) a reclassification, capital reorganization or other change or exchange of outstanding shares of the
Common Stock, other than a forward or reverse stock split or stock dividend, or (iii) any consolidation or merger of the Company
with or into another person or entity in which the Company is not the surviving entity (other than a merger which is effected
solely to change the jurisdiction of incorporation of the Company and results in a reclassification, conversion or exchange of
outstanding shares of Common Stock solely into shares of Common Stock) (each of items (i), (ii) and (iii) being referred to as
a “Sale Event”), then, in each case, the Company shall, upon request of the Holder, redeem this Note in cash for 150%
of the principal amount, plus accrued but unpaid interest through the date of redemption, or at the election of the Holder, such
Holder may convert the unpaid principal amount of this Note (together with the amount of accrued but unpaid interest) into shares
of Common Stock immediately prior to such Sale Event at the Conversion Price.

 

(e)
In case of any Sale Event (not to include a sale of all or substantially all of the Company’s assets) in connection with
which this Note is not redeemed or converted, the Company shall cause effective provision to be made so that the Holder of this
Note shall have the right thereafter, by converting this Note, to purchase or convert this Note into the kind and number of shares
of stock or other securities or property (including cash) receivable upon such reclassification, capital reorganization or other
change, consolidation or merger by a holder of the number of shares of Common Stock that could have been purchased upon exercise
of the Note and at the same Conversion Price, as defined in this Note, immediately prior to such Sale Event. The foregoing provisions
shall similarly apply to successive Sale Events. If the consideration received by the holders of Common Stock is other than cash,
the value shall be as determined by the Board of Directors of the Company or successor person or entity acting in good faith.

 

    	3

    	 

    

 

5.
No provision of this Note shall alter or impair the obligation of the Company, which is absolute and unconditional, to pay the
principal of, and interest on, this Note at the time, place, and rate, and in the form, herein prescribed.

 

6.
The Company hereby expressly waives demand and presentment for payment, notice of non-payment, protest, notice of protest, notice
of dishonor, notice of acceleration or intent to accelerate, and diligence in taking any action to collect amounts called for
hereunder and shall be directly and primarily liable for the payment of all sums owing and to be owing hereto.

 

7.
The Company agrees to pay all costs and expenses, including reasonable attorneys’ fees and expenses, which may be incurred
by the Holder in collecting any amount due under this Note.

 

8.
If one or more of the following described “Events of Default” shall occur:

 

(a)
The Company shall default in the payment of principal or interest on this Note or any other note issued to the Holder by the Company;
or

 

(b)
Any of the representations or warranties made by the Company herein or in any certificate or financial or other written statements
heretofore or hereafter furnished by or on behalf of the Company in connection with the execution and delivery of this Note, or
the Securities Purchase Agreement under which this note was issued shall be false or misleading in any respect; or

 

(c)
The Company shall fail to perform or observe, in any respect, any covenant, term, provision, condition, agreement or obligation
of the Company under this Note or any other note issued to the Holder; or

 

(d)
The Company shall (1) become insolvent; (2) admit in writing its inability to pay its debts generally as they mature; (3) make
an assignment for the benefit of creditors or commence proceedings for its dissolution; (4) apply for or consent to the appointment
of a trustee, liquidator or receiver for its or for a substantial part of its property or business; (5) file a petition for bankruptcy
relief, consent to the filing of such petition or have filed against it an involuntary petition for bankruptcy relief, all under
federal or state laws as applicable; or

 

    	4

    	 

    

 

(e)
A trustee, liquidator or receiver shall be appointed for the Company or for a substantial part of its property or business without
its consent and shall not be discharged within sixty (60) days after such appointment; or

 

(f)
Any governmental agency or any court of competent jurisdiction at the instance of any governmental agency shall assume custody
or control of the whole or any substantial portion of the properties or assets of the Company; or

 

(g)
One or more money judgments, writs or warrants of attachment, or similar process, in excess of fifty thousand dollars ($50,000)
in the aggregate, shall be entered or filed against the Company or any of its properties or other assets and shall remain unpaid,
unvacated, unbonded or unstayed for a period of fifteen (15) days or in any event later than five (5) days prior to the date of
any proposed sale thereunder; or

 

(h)
The Company shall have defaulted on or breached any term of any other note of similar debt instrument into which the Company has
entered and failed to cure such default within the appropriate grace period; or

 

(i)
The Company shall have its Common Stock delisted from an exchange (including the OTC Market exchange) or, if the Common Stock
trades on an exchange, then trading in the Common Stock shall be suspended for more than 10 consecutive days;

 

(j)
If a majority of the members of the Board of Directors of the Company on the date hereof are no longer serving as members of the
Board;

 

(k)
The Company shall not deliver to the Holder the Common Stock pursuant to paragraph 4 herein without restrictive legend within
3 business days of its receipt of a Notice of Conversion; or

 

(l)
The Company shall not replenish the reserve set forth in Section 12, within 3 business days of the request of the Holder.

 

(m)
The Company shall not be “current” in its filings with the Securities and Exchange Commission; or

 

(n)
The Company shall lose the “bid” price for its stock in a market (including the OTC marketplace or other exchange).

 

Then,
or at any time thereafter, unless cured within 5 days, and in each and every such case, unless such Event of Default shall have
been waived in writing by the Holder (which waiver shall not be deemed to be a waiver of any subsequent default) at the option
of the Holder and in the Holder’s sole discretion, the Holder may consider this Note immediately due and payable, without
presentment, demand, protest or (further) notice of any kind (other than notice of acceleration), all of which are hereby expressly
waived, anything herein or in any note or other instruments contained to the contrary notwithstanding, and the Holder may immediately,
and without expiration of any period of grace, enforce any and all of the Holder’s rights and remedies provided herein or
any other rights or remedies afforded by law. Upon an Event of Default, interest shall accrue at a default interest rate of 24%
per annum or, if such rate is usurious or not permitted by current law, then at the highest rate of interest permitted by law.
In the event of a breach of Section 8(k) the penalty shall be $250 per day the shares are not issued beginning on the 4th
day after the conversion notice was delivered to the Company. This penalty shall increase to $500 per day beginning on the
10th day. The penalty for a breach of Section 8(n) shall be an increase of the outstanding principal amounts by 20%.
If this Note is not paid at maturity, the outstanding principal due under this Note shall increase by 10%. Further, if a breach
of Section 8(o) occurs, or is continuing after the 6 month anniversary of the Note, then the Holder shall be entitled, while such
breach remains uncured, to use the lowest trading price during the period starting on the date of the breach and ending on the
day the breach is remedied, as a base price for the conversion.

 

    	5

    	 

    

 

If
the Holder shall commence an action or proceeding to enforce any provisions of this Note, including, without limitation, engaging
an attorney, then if the Holder prevails in such action, the Holder shall be reimbursed by the Company for its attorneys’
fees and other costs and expenses incurred in the investigation, preparation and prosecution of such action or proceeding.

 

9.
In case any provision of this Note is held by a court of competent jurisdiction to be excessive in scope or otherwise invalid
or unenforceable, such provision shall be adjusted rather than voided, if possible, so that it is enforceable to the maximum extent
possible, and the validity and enforceability of the remaining provisions of this Note will not in any way be affected or impaired
thereby.

 

10.
Neither this Note nor any term hereof may be amended, waived, discharged or terminated other than by a written instrument signed
by the Company and the Holder.

 

11.
The Company represents that it is not a “shell” issuer and has never been a “shell” issuer or that if
it previously has been a “shell” issuer that at least 12 months have passed since the Company has reported form 10
type information indicating it is no longer a “shell” issuer. Further. The Company will instruct its counsel to either
(i) write a 144 opinion to allow for salability of the conversion shares or (ii) accept such opinion from Holder’s counsel.

 

12.
The Company shall issue irrevocable transfer agent instructions reserving 38,981,000 shares of its Common Stock for conversions
under this Note (the “Share Reserve”). Upon full conversion of this Note, any shares remaining in the Share Reserve
shall be cancelled. The Company shall pay all costs associated with issuing and delivering the shares. If such amounts are to
be paid by the Holder, it may deduct such amounts from the principal amount being converted. The company should at all times reserve
a minimum of four times the amount of shares required if the note would be fully converted. The Holder may reasonably request
increases from time to time to reserve such amounts. The Company will instruct its transfer agent to provide the outstanding share
information to the Holder in connection with its conversions.

 

13.
The Company will give the Holder direct notice of any corporate actions, including but not limited to name changes, stock splits,
recapitalizations etc. This notice shall be given to the Holder as soon as possible under law.

 

    	6

    	 

    

 

14.
If it shall be found that any interest or other amount deemed interest due hereunder violates the applicable law governing usury,
the applicable provision shall automatically be revised to equal the maximum rate of interest or other amount deemed interest
permitted under applicable law. The Company covenants (to the extent that it may lawfully do so) that it will not seek to claim
or take advantage of any law that would prohibit or forgive the Company from paying all or a portion of the principal or interest
on this Note.

 

15.
This Note shall be governed by and construed in accordance with the laws of New York applicable to contracts made and wholly to
be performed within the State of New York and shall be binding upon the successors and assigns of each party hereto. The Holder
and the Company hereby mutually waive trial by jury and consent to exclusive jurisdiction and venue in the courts of the State
of New York or in the Federal courts sitting in the county or city of New York. This Agreement may be executed in counterparts,
and the facsimile transmission of an executed counterpart to this Agreement shall be effective as an original.

 

[signature
page follows]

 

    	7

    	 

    

 

IN
WITNESS WHEREOF, the Company has caused this Note to be duly executed by an officer thereunto duly authorized.

 

Dated:
July 15, 2020

 

	 	TODOS
    MEDICAL LTD.
	 	 	 
	 	 	/s/ Daniel Hirsch
	 	By:	Daniel
    Hirsch
	 	Title:	CFO

 

    	8

    	 

    

 

EXHIBIT
A

 

NOTICE
OF CONVERSION

 

(To
be Executed by the Registered Holder in order to Convert the Note)

 

The
undersigned hereby irrevocably elects to convert $___________ of the above Note into _________ Shares of Common Stock of TODOS
MEDICAL LTD. (“Shares”) according to the conditions set forth in such Note, as of the date written below.

 

If
Shares are to be issued in the name of a person other than the undersigned, the undersigned will pay all transfer and other taxes
and charges payable with respect thereto.

 

Date
of Conversion:______________________________________________________

Applicable
Conversion Price: ______________________________________________

Signature:
_____________________________________________________________

                                                 [Print Name of Holder and Title of Signer]

Address:
______________________________________________________________

                 ______________________________________________________________

 

SSN
or EIN: ___________________________

Shares
are to be registered in the following name: _______________________________________

 

Name:________________________________________________________________

Address:______________________________________________________________

Tel:___________________________

Fax:
__________________________

SSN
or EIN: ____________________

 

Shares
are to be sent or delivered to the following account:

 

Account
Name: ________________________________________________________

Address:
_____________________________________________________________

 

    	9

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