Document:

Second Amendment of Lease

 Exhibit 10.59 
 SECOND AMENDMENT OF LEASE 
 THIS SECOND
AMENDMENT OF LEASE is made this 23rd day of March, 2007,
by and between RB KENDALL FEE, LLC (“Landlord”) and CEQUENT PHARMACEUTICALS, INC., having a mailing address at One Kendall Square, Building 600/700, Cambridge, Massachusetts 02139 (“Tenant”).

 R E C I T A L S: 

A. Reference is made to an Indenture of Lease dated December 19, 2006, by and between Landlord, and Tenant, as amended by First
Amendment of Lease also dated December 19, 2006 (as amended, the “Lease”) demising approximately 4,629 s.f. of rentable square feet of space on a portion of the first floor and approximately 456 s.f. of rentable space in the
basement of the Building 600/700 at One Kendall Square, Cambridge, Massachusetts. Capitalized terms used but not defined herein shall have the same meaning as in the Lease. 
 B. Landlord and Tenant are the current holders, respectively, of the lessor’s and lessee’s interests in the Lease. 
 C. Landlord and Tenant now desire to amend the Lease as set forth herein. 

A G R E E M E N T S: 

NOW, THEREFORE, in consideration of the mutual covenants and agreements herein contained, and for other good and valuable consideration,
the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant hereby agree to amend the Lease as follows: 

1. Notwithstanding anything in the Lease to the contrary, Tenant shall, for the Term of the Lease only, as same may be extended pursuant
to Section 29.15 of the Lease, have the exclusive license to use the Storage Space (approximately 98 s.f.) in the basement of Building 600/700 at One Kendall Square, Cambridge, Massachusetts as shown as unit #2 on the plan attached hereto as
Exhibit A-1 (“Storage Space”), for the storage of Tenant’s personal property and effects relating to its permitted use of the premises under the Lease and for no other purpose(s). Except as otherwise provided herein, Tenant’s use
of the Storage Space shall be subject to all of the terms and conditions of the Lease. Tenant agrees to pay to Landlord, in advance and as additional rent under the Lease without demand, offset or deduction, at the same time as monthly installments
of Yearly Rent are due under the Lease, a license fee equal to $89.83 per month during each month of the Term. In the event of the termination or expiration of the Lease, Tenant’s license to use the Storage Space, if not already terminated or
expired, shall immediately terminate without any further notice or demand. Tenant agrees that it is taking the Storage Space “as-is”, in the condition in which the Storage Space is in as of the date hereof, without any obligation on the
part of Landlord to prepare or construct the Storage Space for Tenant’s occupancy and without any warranty or representation by Landlord as to the condition of the Storage Space or its fitness for any use or purpose. Tenant shall keep neat and
clean and maintain in good order, condition and repair, the Storage Space excepting only damage by fire or other casualty or as a consequence of the exercise of the power of eminent domain and reasonable wear and tear and Tenant shall surrender the
Storage Space at the expiration of the Lease, unless sooner terminated, in such condition, free of all personal property and effects. Tenant shall maintain and use the Storage Space in accordance with all Federal, State, County

 
and Municipal laws, rules, orders and regulations. Tenant acknowledges and agrees that Landlord shall have no obligation to provide cleaning or other services to the Storage Space. In addition to
the other termination rights set forth in the Lease, either party shall have the right to terminate this license to use the Storage Space upon not less than thirty (30) days written notice to the other party, and upon such termination Tenant
shall surrender the Storage Space as set forth above. 
 2. Landlord and Tenant each warrant and represent to the other that
they have dealt with no brokers in connection with the negotiation or consummation of this Second Amendment and in the event of any brokerage claim against either party by any person claiming to have dealt with either Landlord or Tenant in
connection with this Second Amendment, the party with whom such person claims to have dealt shall defend and indemnify the other party against such claim. 
 3. In all other respects the Lease shall remain unmodified and shall continue in full force and effect, as amended hereby. The parties hereby ratify, confirm, and reaffirm all of the terms and conditions
of the Lease, as amended hereby. 
 IN WITNESS WHEREOF the parties hereto have executed this Second Amendment of Lease on the
date first written above in multiple copies, each to be considered an original hereof, as a sealed instrument. 
  

							
	 LANDLORD:
	 	TENANT:
		
	 RB KENDALL FEE, LLC,
	 	CEQUENT PHARMACEUTICALS, INC.,
	 a Delaware limited liability company
	 	a Delaware corporation
				
	 By:
	 	 /s/ Robert L. Beal
	 	By:	 	 /s/ Peter D. Parker

		 	 Robert L. Beal, its authorized signatory
	 		 	Name: Peter D. Parker
		 		 		 	Title: President and CEOThird Amendment of Lease

 Exhibit 10.60 
 THIRD AMENDMENT OF LEASE 
 THIS THIRD AMENDMENT
OF LEASE is made this 20th day of September, 2007, by and
between RB KENDALL FEE, LLC (“Landlord”) and CEQUENT PHARMACEUTICALS, INC., having a mailing address at One Kendall Square, Building 600/700, Cambridge, Massachusetts 02139
(“Tenant”). 
 R E C I T A L S:

 A. Reference is made to an Indenture of Lease dated December 19, 2006, by and between Landlord, and Tenant, as amended
by First Amendment of Lease also dated December 19, 2006 and Second Amendment of Lease dated March 23, 2007 (as amended, the “Lease”) demising approximately 4,629 s.f. of rentable square feet of space on a portion of the
first floor, approximately 456 s.f. of rentable space in the basement (collectively, the “Original Premises”) and approximately 98 s.f. of storage space in the basement of Building 600/700 at One Kendall Square, Cambridge, Massachusetts.
Capitalized terms used but not defined herein shall have the same meaning as in the Lease. 
 B. Landlord and Tenant are the
current holders, respectively, of the lessor’s and lessee’s interests in the Lease. 
 C. Landlord and Tenant now
desire to amend the Lease as set forth herein. 
 A G R E E M E N
T S: 
 NOW, THEREFORE, in consideration of the mutual covenants and agreements herein contained, and for other
good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant hereby agree to amend the Lease as follows: 

1. Commencing on the date Landlord substantially completes Landlord’s Work (as defined herein) and delivers the
Additional Premises (as defined herein) (the “Additional Premises Commencement Date”) to Tenant and continuing through the expiration of the term on May 31, 2010, the premises demised under the Lease shall be deemed to include the
approximately 1,768 s.f. of rentable square feet of space located on the first floor of Building 600/700 within the Complex, as more particularly shown crosshatched on the plan attached hereto as Exhibit A-l (the “Additional Premises”)
together with the Original Premises. Tenant shall be permitted to use the Additional Premises for only the purposes set forth in the Lease. Except as otherwise provided herein, Tenant’s use of the Additional Premises shall be subject to all of
the terms and conditions of the Lease. Yearly Rent for the Additional Premises shall be as follows: For the period commencing thirty (30) days after the Additional Premises Commencement Date (the “Additional Premises Rent Commencement
Date”) through the end of the 12th complete month
following the Additional Premises Rent Commencement Date, $61,880.00, payable in monthly installments of $5,156.67, as set forth in Lease; For month 13 through month 24, $63,648.00, payable in monthly installments of $5,304.00, as set forth in the
Lease and for month 25 through May 31, 2010, $65,416.00, payable in monthly installments of $5,451.33, as set forth in the Lease. 
 2. Tenant’s Proportionate Building Share with respect to the Additional Premises shall be 0.738% and Tenant’s Proportionate Common Share with respect to the Additional Premises shall be 0.268%
(the “Additional Premises Share”). Commencing as of Additional Premises Rent Commencement Date and continuing throughout the term of the Lease, and in addition to the Tax Share and Operating Expense Share payable by Tenant under the Lease
for the Original Premises, Tenant shall pay the its Tax Share and Operating Expense Share in respect of the Additional Premises based upon the Additional Premises Share. Tenant shall also pay for its use of utilities in the Additional Premises on a
pro rata basis as billed by Landlord. 

 3. Tenant agrees that, with the exception of physically connecting the Original Premises to
the Additional Premises by re-opening an existing doorway or passageway, erecting a demising wall to segregate the Additional Premises from the remaining space within the floor of the Building and repairing any walls, carpeting or paint impacted by
such work (collectively, the “Landlord’s Work”), as depicted on Exhibit A-2, which Landlord shall perform at its expense, Tenant is taking the Additional Premises “as-is”, in the condition in which the Additional Premises is
in as of the date hereof, without any obligation on the part of Landlord to prepare or construct the Additional Premises for Tenant’s occupancy and without any warranty or representation by Landlord as to the condition of the Additional
Premises or its fitness for any use or purpose. Subject to delay by causes beyond the reasonable control of Landlord or caused by the action or inaction of Tenant, Landlord shall use reasonable speed and diligence to have the Landlord’s Work
substantially completed by September 1, 2007. The failure to have the Additional Premises ready for Tenant’s occupancy on September 1, 2007 shall in no way affect the validity of this Third Amendment or the obligations of Tenant
hereunder nor shall the same be construed in any way to extend the term of the Lease as amended by this Third Amendment. If the Additional Premises is not ready for Tenant’s occupancy on September 1,2007, Tenant shall not have any claim
against Landlord, and Landlord shall have no liability to Tenant, by reason thereof. 
 4. With the exception of the
Landlord’s Work, Tenant shall be responsible for all leasehold improvement work necessary to prepare the Additional Premises for occupancy by Tenant (the “Tenant’s Work”). Tenant’s Work shall be subject to Landlord’s
approval of plans for said work and shall otherwise be subject to the provisions of the Lease, including, without limitation, Sections 12 and 13 of the Lease. As an inducement to Tenant entering into this Third Amendment, and subject to the terms
and conditions set forth herein Landlord shall pay to Tenant for reimbursement of its hard and soft costs in connection with Tenant’s Work, including, without limitation, telephone and data cabling costs, up to a maximum amount of $17,680.00
(the “Landlord’s Contribution”). Tenant shall have the right to obtain payment of the Landlord’s Contribution at any time after Tenant’s Work has been completed, and provided Tenant has occupied the Additional Premises for
the permitted use, by submitting to Landlord (i) a detailed statement, including third party invoices and other documentation reasonably requested by Landlord evidencing the total cost of, and payment for Tenant’s Work, and (ii) all
lien waivers relating to items, services and work performed in connection with all phases or portions of Tenant’s Work. Notwithstanding anything to the contrary contained in the Lease: (i) Landlord’s obligation to pay Landlord’s
Contribution shall be conditioned upon there existing no default by Tenant in its obligations under the Lease at the time that Landlord would be required to make such payment; and (ii) Landlord shall have no obligation to advance any funds or
pay any amounts on account of Tenant’s Work in excess of Landlord’s Contribution. 
 5. Landlord and Tenant each
warrant and represent to the other that they have dealt with no brokers in connection with the negotiation or consummation of this Third Amendment except for Beal and Company, Inc. and in the event of any brokerage claim against either party by any
person claiming to have dealt with either Landlord or Tenant in connection with this Third Amendment, the party with whom such person claims to have dealt shall defend and indemnify the other party against such claim. 

  
 2 

 6. In all other respects the Lease shall remain unmodified and shall continue in full force
and effect, as amended hereby. The parties hereby ratify, confirm, and reaffirm all of the terms and conditions of the Lease, as amended hereby. 

  
 3 

 IN WITNESS WHEREOF the parties hereto have executed this Third Amendment of Lease on the
date first written above in multiple copies, each to be considered an original hereof, as a sealed instrument. 
  

									
	LANDLORD:	 		 	TENANT:
			
	RB KENDALL FEE, LLC,	 		 	CEQUENT PHARMACEUTICALS, INC.,
	a Delaware limited liability company	 		 	a Delaware corporation
					
	By:	 	/s/ Robert L. Beal	 		 	By:	 	/s/ Peter D. Parker
		 	Robert L. Beal, its authorized signatory	 		 		 	Name: Peter D. Parker
		 		 		 		 	Title: President

  
 4

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00186-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00186-of-00352.parquet"}]]