Document:

EXHIBIT 4.19

ISOTIS SA

STOCK OPTION PLAN 2003/0

(former Employees and Board members)
(Consultants)
 (Collaborative Institutions)

	
  
1.
  	
  
Purpose
  
	
  
 
  	
  
 
  
	
  
 
  	
  
The purpose of this Stock Option Plan (the Plan) is to advance the   interests of IsoTis SA (the Company) and its subsidiaries, whether in   Switzerland or abroad (the Subsidiaries), by i) replacing options held before   the Merger with IsoTis N.V. by former employees and Board members, and ii)   enhancing the ability of the Company and its Subsidiaries to attract and retain   Consultants and Collaborative Institutions who are in a position to make a   significant contribution to the success of the Company or its Subsidiaries   through ownership of shares of the Company’s common stock.
  
	
  
 
  	
  
 
  
	
  
 
  	
  
The Plan is intended to accomplish these goals by enabling the   Company to grant Options.
  
	
   
  	
  
 
  
	
  
 
  	
  
The Plan is based on [**] shares of Common   Stock of the Company, with a par value of CHF 1.- per share, held by the   Company. If   any Option granted according to this Plan terminates without having been   exercised, the corresponding share will be available for future grants under   this Plan.
  
	
  
 
  	
  
 
  
	
  
 
  	
  
The Plan rules the conditions and   modalities of the grant and exercise of such Options.
  
	
  
 
  	
  
 
  
	
  
2.
  	
  
Administration
  
	
  
 
  	
  
 
  
	
  
 
  	
  
The Plan will be administrated by the Board of Directors of the   Company (the Board). All decisions shall be taken at the majority provided   for by article 24 of the Articles of Incorporation.
  
	
  
 
  	
  
 
  
	
   
  	
  
Subject to the provisions of the Plan, the Board will have authority   to
  
	
  
 
  	
  
 
  
	
  
 
  	
  
a)
  	
  
grant Options at such time or times as it may choose;
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
b)
  	
  
determine the terms and conditions of each Option;
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
c)
  	
  
select the persons eligible to receiving Options;
  

1

	
   
  	
  
d)
  	
  
amend the conditions of existing Options, including but not limited   to the modification of the exercise price, or cancel existing Options, in   whole or in part, except that the Board may not, without the consent of the   holder of an Option, take any action under this clause with respect to such   Option if such action would adversely affect the right of such holder   (Section 9 hereafter being reserved);
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
e)
  	
  
amend or rescind the Plan;
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
f)
  	
  
adopt, amend and rescind rules and regulations for the administration   of the Plan;
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
g)
  	
  
interpret the Plan and decide any questions and settle all   controversies and disputes that may arise in connection with the Plan, such   decisions being binding for all parties;
  
	
   
  	
  
 
  	
  
 
  
	
  
 
  	
  
h)
  	
  
delegate all or part of its responsibilities under the Plan to one or   several Board member.
  
	
  
 
  	
  
 
  	
  
 
  
	
  
3.
  	
  
Effective   date
  
	
  
 
  	
  
 
  
	
  
 
  	
  
The Plan will be effective on the date on which it is approved by the   Board.
  
	
  
 
  	
  
 
  
	
  
4.
  	
  
Eligibility   and Participation
  
	
  
 
  	
  
 
  
	
   
  	
  
Those eligible to receive Options under the Plan will be i) former   employees as well as former Board members, ii) Consultants, and iii)   Collaborative Institutions - such as Universities - of the Company or its   Subsidiaries.
  
	
  
 
  	
  
 
  
	
  
 
  	
  
The Plan gives no right to employees or Board members to be granted   Options. The grant of Options gives no right to be granted other Options.
  
	
  
 
  	
  
 
  
	
  
 
  	
  
A Participant is a former employee, a former Board member, a   Consultant, or a Collaborative Institution to whom Options have been granted   according to the Plan.
  
	
  
 
  	
  
 
  
	
  
 
  	
  
A Participant who is granted Options will have no rights with respect   to such Options unless the Participant accepts the Options by returning to   the Company a signed copy of the Award Agreement drafted by the Company and   specifying the terms and conditions of such Options (the Award Agreement).
  

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5.
  	
  
Options
  
	
  
 
  	
  
 
  
	
  
 
  	
  
An Option entitles the recipient, on exercise thereof in accordance   with the provisions of the Plan and of the Award Agreement, to acquire from   the Company one registered shares of Common Stock of the Company with a   par value of CHF 1.-   at a specified exercise price.
  
	
  
 
  	
  
 
  
	
  
6.
  	
  
Grant of   Options
  
	
  
 
  	
  
 
  
	
  
 
  	
  
The Board may grant Options at any time. The Board shall determine   the size as well as the terms and conditions of each Option. The Options are   granted as of the Date of Grant specified in the Award Agreement.
  
	
   
  	
  
 
  
	
  
7.
  	
  
Exercise of   Options
  
	
  
 
  	
  
 
  
	
  
 
  	
  
a)
  	
  
Vesting Time : The Vesting Time, if any, will be defined   by the Board in the Award Agreement. The Board may at any time accelerate the   time at which all or any part of the Options may be exercised.
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
b)
  	
  
Duration of Options : The latest date on which an Option may be   exercised will be defined by the Board in the Award Agreement, subject to the   provisions of Sections 8 and 9. The Board may at any time shorten or extend   the duration during which the Option may be exercised.
  
	
  
 
  	
  
 
  	
  
 
  
	
   
  	
  
c)
  	
  
Exercisable Periods : Once exercisable, Options may be exercised   at any moment until they are extinguished as per Section 7 b). However,  Options cannot be exercised during i) a   period starting thirty days prior to the date of an ordinary or an   extraordinary shareholders’ meeting of the Company and ending the fifth day   following the date of such meeting and ii) three weeks preceding the   announcement of quarterly results. The provisions of Section 11 below   (Insider Trading and Code of Conduct) shall apply. .
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
d)
  	
  
Depositary accounts : a frozen account (the Frozen Account) will   be opened for each Participant with UBS SA in Lausanne (or any other Bank   designated by the Company), on which the Options will be deposited. A current   account (the Current Account) will be related to each Participant’s Frozen   Account.
  

3

	
  
 
  	
  
e)
  	
  
Manner of Exercise : Each Participant will have the possibility   of effecting a partial exercise of his Options.
  
	
   
  	
  
 
  	
  
 
  
	
  
 
  	
  
f)
  	
  
Transfer limitations : the newly issued registered shares shall   be subject to the transfer limitations foreseen in articles 9 and 10 of the   Articles of Incorporation.
  
	
  
 
  	
  
 
  	
  
 
  
	
  
8.
  	
  
Events   affecting Outstanding Awards
  
	
  
 
  	
  
 
  
	
  
 
  	
  
a)
  	
  
Death
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
 
  	
  
If a   Participant dies, except as otherwise determined by the Board, all Options   held by the Participant prior to death shall become immediately exercisable   at the date of death. All Options will continue to be exercisable for a   period of six months from the date of death and shall thereupon terminate and   the Company shall have no further obligation under the Plan. In no event,   however, shall an Option remain exercisable beyond the latest date on which   it could have been exercised without regard to this Section.
  
	
   
  	
  
 
  	
  
 
  
	
  
 
  	
  
b)
  	
  
Disability   or Retirement
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
 
  	
  
If a   Participant - other than a former employee, a former Board member or a Collaborative   Institution - ceases to be a Consultant of the Company or its Subsidiaries by   reason of disability or retirement, all Options shall become immediately   exercisable at the date of disability (the date of its occurrence being   determined by a physician selected or approved by the Board) or of   retirement. All Options will continue to be exercisable for a period of three   months from the date of disability or retirement (or such longer period as   the Board may determine), and shall thereupon terminate and the Company shall   have no further obligation under the Plan. In no event, however, shall an   Option remain exercisable beyond the latest date on which it could have been   exercised without regard to this Section.
  
	
  
 
  	
  
 
  	
  
 
  
	
  
    9.
  	
  
Certain   Corporate Transactions
  
	
   
  	
  
 
  	
  
 
  
	
  
 
  	
  
In the event or in view of a merger or a sale of all or substantially   all of the assets of the Company to another person or entity or a dissolution   or liquidation of the Company or the closing of an underwritten public   offering of the Company’s Stock, or the like (a “Covered Transaction”), all   existing Options will be terminated as of the effective date of the Covered   Transaction, except as otherwise decided by the Board, and the following   rules shall apply :
  

4

	
  
 
  	
  
a)
  	
  
Subject to paragraph b) below, the Board may at its sole discretion,   prior to the effective date of the Covered Transaction, (i) make each   existing Option exercisable in full, and/or (ii) change the duration period   of each exercisable Option such as all exercisable Options must be exercised   within a period of 30 days minimum.
  
	
  
 
  	
  
 
  	
  
 
  
	
   
  	
  
b)
  	
  
With respect to existing Options held by a Participant who, following   the Covered Transaction, will be employed by or otherwise providing services   to a corporation which is the surviving or acquiring corporation in such   transaction or an affiliate of such corporation, the Board may, in lieu of   the actions described in paragraph a) above, arrange to have such surviving   or acquiring corporation or affiliate grant to the Participant replacement Options,   which in the judgment of the Board, are substantially equivalent to the   existing Options.
  
	
  
 
  	
  
 
  	
  
 
  
	
  
10.
  	
  
    General   Provisions

  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
a)
  	
  
Non-transferability   of Options
  
	
  
 
  	
  
 
  	
  
 
  
	
   
  	
  
 
  	
  
No Options   under the Plan may be pledged, assigned or transferred other than by will or   the laws of descent. Should any transfer occur by operation of law, the   transferee shall, to the maximum extent permitted by law, be bound by the   terms of this Plan.
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
b)
  	
  
Adjustment   in the Event of Certain Transactions
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
 
  	
  
In the event   of a change in the Common Stock of the Company by reasons of an issuance of   shares at less than their market value (including stock dividend and the   like), if the shareholders of the Company do not suffer the same   disadvantage, the Board of Directors may proportionally adjust, in an   equitable manner, either the number of granted Options and/or the exercise   price relating to the granted Options.
  
	
  
 
  	
  
 
  	
  
 
  
	
   
  	
  
c)
  	
  
Taxation   and Social Security
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
 
  	
  
The   Participant will bear any and all tax and social security related to the   grant and/or the exercise of Options, and shall reimburse to the Company any   such tax or social security which may have been paid by the Company. However,   the stamp duty on issuance of the shares shall be borne by the Company.
  

5

	
  
 
  	
  
d)
  	
  
Other restrictions
  
	
  
 
  	
  
 
  	
  
 
  
	
   
  	
  
 
  	
  
Notwithstanding the other articles of the Plan, the   following restrictions apply to Consultant and Collaborative Institutions:
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
 
  	
  
(i)     In case of   termination of the contractual relationship between the Participant and the   Company, the Participant will not be entitled to any compensation for any   losses suffered due to the fact that participation in the Plan is terminated.
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
 
  	
  
(ii)    The grant   of Options is under no circumstances to be considered as a guarantee for   continuation of the contractual relationship between the Participant and the   Company.
  
	
  
 
  	
  
 
  	
  
 
  
	
   
  	
  
e)
  	
  
Severability
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
 
  	
  
In the event   that any one or more of the provision of this Plan shall for any reason be   held by any court of competent jurisdiction to be void, illegal or   unenforceable in any respect, such invalidity, illegality or unenforceability   shall not affect any other provision of this Plan and such invalid, illegal   or unenforceable provision shall be reformed and construed so that it will be   valid, legal and enforceable to the maximum extent permitted by law.
  
	
  
 
  	
  
 
  	
  
 
  
	
  
11.
  	
  
    Insider   Trading and Code of Conduct

  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
The exercise   of Options by the Participants must comply with the applicable regulations,   including insider trading regulations.
  
	
   
  	
  
 
  
	
  
 
  	
  
The Board is   authorised to refuse the exercise of Options, if the Board has reasons to   believe, at its sole discretion, that such exercise would breach such   regulations, including any regulations issued by the Company to prevent   insider trading operations.
  
	
  
 
  	
  
 
  
	
  
 
  	
  
The Code of Conduct enclosed to the Award Agreement as Schedule 2   applies to the Participant, who hereby agrees to be bound by its terms.
  

6

Plan approved by the Board of Directors of IsoTis SA  on November 27, 2002.

	
  
 
  	
  
 
  	
  
IsoTis SA
  
	
  
 
  	
  
 
  	
  
 
  
	
   
  	
   
  	
   
  
	
   
  	
   
  	
   
  
	
   
  	
   
  	
   
  
	
   
  	
   
  	
   
  
	
   
  	
   
  	
   
  
	
  Read and approved on ___________________
  	
   
  	
   
  
	
   
  	
   
  	
   
  
	
   
  	
   
  	
   
  
	
   
  	
   
  	
   
  
	
   
  	
   
  	
  The Participant
  
	
   
  	
   
  	
   
  
	
   
  	
   
  	
   
  
	
   
  	
   
  	
  

  

7EXHIBIT 4.20

ISOTIS SA

STOCK OPTION PLAN 2003/1

(Employees and Board members)

	
  
1.
  	
  
Purpose
  
	
  
 
  	
  
 
  
	
  
 
  	
  
The purpose of this Stock Option Plan (the Plan) is to advance the   interests of IsoTis SA (the Company) and its subsidiaries, whether in   Switzerland or abroad (the Subsidiaries), by enhancing their ability to   attract and retain employees and Board members who are in a position to make   a significant contribution to the success of the Company or its Subsidiaries   through ownership of shares of the Company’s common stock.
  
	
  
 
  	
  
 
  
	
  
 
  	
  
The Plan is intended to accomplish these goals by enabling the   Company to grant Options.
  
	
   
  	
  
 
  
	
  
 
  	
  
The Plan is based on article 7 of the   Articles of Incorporation, which provides for a conditional increase of the   share capital of a maximum of CHF 4,000,000.- by the issuance of a maximum of   4,000,000 registered shares, with a par value of CHF 1.- per share, through   the exercise of Option rights to be granted to employees as well as Board   members of the Company.
  
	
  
 
  	
  
 
  
	
  
 
  	
  
The Plan rules the conditions and modalities   of the grant and exercise of such Options.
  
	
  
 
  	
  
 
  
	
  
2.
  	
  
Administration
  
	
  
 
  	
  
 
  
	
  
 
  	
  
The Plan will be administrated by the Board of Directors of the   Company (the Board). All decisions shall be taken by the majority provided   for by article 24 of the Articles of Incorporation.
  
	
   
  	
  
 
  
	
  
 
  	
  
Subject to the provisions of the Plan, the Board will have authority   to
  
	
  
 
  	
  
 
  
	
  
 
  	
  
a)
  	
  
grant Options at such time or times as it may choose;
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
b)
  	
  
determine the terms and conditions of each Option;
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
c)
  	
  
select the persons eligible to receiving Options;
  

	
  
 
  	
  
d)
  	
  
amend the conditions of existing Options, including but not limited   to the modification of the exercise price, or cancel existing Options, in   whole or in part, except that the Board may not, without the consent of the   holder of an Option, take any action under this clause with respect to such   Option if such action would adversely affect the right of such holder   (Section 9 hereafter being reserved);
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
e)
  	
  
amend or rescind the Plan;
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
f)
  	
  
adopt, amend and rescind rules and regulations for the administration   of the Plan;
  
	
   
  	
  
 
  	
  
 
  
	
  
 
  	
  
g)
  	
  
interpret the Plan and decide any questions and settle all   controversies and disputes that may arise in connection with the Plan, such   decisions being binding for all parties;
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
h)
  	
  
delegate all or part of its responsibilities under the Plan to one or   several Board member.
  
	
  
 
  	
  
 
  	
  
 
  
	
  
3.
  	
  
Effective   date
  
	
  
 
  	
  
 
  
	
  
 
  	
  
The Plan will be effective on the date on which it is approved by the   Board.
  
	
   
  	
  
 
  
	
  
4.
  	
  
Eligibility   and Participation
  
	
  
 
  	
  
 
  
	
  
 
  	
  
Those eligible to receive Options under the Plan will be employees as   well as Board members of the Company or its Subsidiaries.
  
	
  
 
  	
  
 
  
	
  
 
  	
  
The Plan gives no right to employees or Board members to be granted   Options. The grant of Options gives no right to be granted other Options.
  
	
  
 
  	
  
 
  
	
  
 
  	
  
A Participant is an employee or a Board member to whom Options have   been granted according to the Plan.
  
	
  
 
  	
  
 
  
	
   
  	
  
A Participant who is granted Options will have no rights with respect   to such Options unless the Participant accepts the Options by returning to   the Company a signed copy of the Award Agreement drafted by the Company and   specifying the terms and conditions of such Options (the Award Agreement).
  

2

	
  
5.
  	
  
Options
  
	
  
 
  	
  
 
  
	
  
 
  	
  
An Option entitles the recipient, on exercise thereof in accordance   with the provisions of the Plan and of the Award Agreement, to subscribe one   registered shares of Common Stock of the Company with a   par value of CHF 1.-   at a specified exercise price.
  
	
  
 
  	
  
 
  
	
  
6.
  	
  
Grant of   Options
  
	
   
  	
  
 
  
	
  
 
  	
  
The Board may grant Options at any time. The Board shall determine   the size as well as the terms and conditions of each Option. The Options are   granted as of the Date of Grant specified in the Award Agreement.
  
	
  
 
  	
  
 
  
	
  
7.
  	
  
Exercise of   Options
  
	
  
 
  	
  
 
  
	
  
 
  	
  
a)
  	
  
Vesting Time : The Vesting Time, if any, will be defined   by the Board in the Award Agreement. The Board may at any time accelerate the   time at which all or any part of the Options may be exercised.
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
b)
  	
  
Duration of Options : The latest date on which an Option may be   exercised will be defined by the Board in the Award Agreement, subject to the   provisions of Sections 8 and 9. The Board may at any time shorten or extend   the duration during which the Option may be exercised.
  
	
   
  	
  
 
  	
  
 
  
	
  
 
  	
  
c)
  	
  
Exercisable Periods : Once exercisable, Options may be exercised   at any moment until they are extinguished as per Section 7 b). However,  Options cannot be exercised during routine   or special blackout periods as described in the Company’s Securities Trading   Policy and Code of Conduct. The provisions of Section 11 below (Insider   Trading and Code of Conduct) shall apply. .
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
d)
  	
  
Depositary accounts : a frozen account (the Frozen Account) will   be opened for each Participant with UBS SA in Lausanne (or any other Bank   designated by the Company), on which the Options will be deposited. A current   account (the Current Account) will be related to each Participant’s Frozen   Account.
  

3

	
   
  	
  
e)
  	
  
Manner of Exercise : Each Participant will have the possibility   of effecting a partial exercise of his Options.
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
f)
  	
  
Transfer limitations : the newly issued registered shares shall   be subject to the transfer limitations foreseen in articles 9 and 10 of the   Articles of Incorporation.
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
g)
  	
  
Dividends : The newly issued registered shares are entitled to dividends as   from the first of January of the year during which they are issued.
  
	
  
 
  	
  
 
  	
  
 
  
	
  
8.
  	
  
Events   affecting Outstanding Awards
  
	
   
  	
  
 
  
	
  
 
  	
  
a)
  	
  
Death
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
 
  	
  
If a   Participant dies, except as otherwise determined by the Board, all Options   held by the Participant prior to death shall become immediately exercisable   at the date of death. All Options will continue to be exercisable for a   period of six months from the date of death and shall thereupon terminate and   the Company shall have no further obligation under the Plan. In no event,   however, shall an Option remain exercisable beyond the latest date on which   it could have been exercised without regard to this Section.
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
b)
  	
  
Disability   or Retirement
  
	
  
 
  	
  
 
  	
  
 
  
	
   
  	
  
 
  	
  
If a   Participant ceases to be an employee or a Board member of the Company or its   Subsidiaries by reason of disability or retirement, all Options shall become   immediately exercisable at the date of disability (the date of its occurrence   being determined by a physician selected or approved by the Board) or of   retirement. All Options will continue to be exercisable for a period of three   months from the date of disability or retirement (or such longer period as   the Board may determine), and shall thereupon terminate and the Company shall   have no further obligation under the Plan. In no event, however, shall an   Option remain exercisable beyond the latest date on which it could have been   exercised without regard to this Section.
  

4

	
  
9.
  	
  
Certain   Corporate Transactions
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
In the event or in view of a merger or a sale of all or substantially   all of the assets of the Company to another person or entity or a dissolution   or liquidation of the Company or the closing of an underwritten public   offering of the Company’s Stock, or the like (a “Covered Transaction”), all   existing Options will be terminated as of the effective date of the Covered   Transaction, except as otherwise decided by the Board, and the following   rules shall apply :
  
	
   
  	
  
 
  	
  
 
  
	
  
 
  	
  
a)
  	
  
Subject to paragraph b) below, the Board may at its sole discretion,   prior to the effective date of the Covered Transaction, (i) make each   existing Option exercisable in full, and/or (ii) change the duration period   of each exercisable Option such as all exercisable Options must be exercised   within a period of 30 days minimum.
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
b)
  	
  
With respect to existing Options held by a Participant who, following   the Covered Transaction, will be employed by or otherwise providing services   to a corporation which is the surviving or acquiring corporation in such   transaction or an affiliate of such corporation, the Board may, in lieu of   the actions described in paragraph a) above, arrange to have such surviving   or acquiring corporation or affiliate grant to the Participant replacement   Options, which in the judgment of the Board, are substantially equivalent to   the existing Options.
  
	
  
 
  	
  
 
  	
  
 
  
	
  10.
  	
  
General   Provisions
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
a)
  	
  
Non-transferability   of Options
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
 
  	
  
No Options   under the Plan may be pledged, assigned or transferred other than by will or   the laws of descent. Should any transfer occur by operation of law, the   transferee shall, to the maximum extent permitted by law, be bound by the   terms of this Plan.
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
b)
  	
  
Adjustment   in the Event of Certain Transactions
  
	
   
  	
  
 
  	
  
 
  
	
  
 
  	
  
 
  	
  
In the event   of a change in the Common Stock of the Company by reasons of an issuance of   shares at less than their market value (including stock dividend and the   like), if the shareholders of the Company do not suffer the same   disadvantage, the Board of Directors may proportionally adjust, in an   equitable manner, either the number of granted Options and/or the exercise   price relating to the granted Options.
  

5

	
  
 
  	
  
c)
  	
  
Taxation   and Social Security
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
 
  	
  
The   Participant will bear any and all tax and social security (employee’s   withholdings) related to the grant and/or the exercise of Options, and shall   reimburse to the Company any such tax or social security which may have been   paid by the Company. However, the stamp duty on issuance of the shares shall   be borne by the Company.
  
	
   
  	
  
 
  	
  
 
  
	
  
 
  	
  
d)
  	
  
Other restrictions
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
 
  	
  
Notwithstanding the other articles of the Plan, the   following restrictions apply:
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
 
  	
  
(i)      In   case of termination of the employment agreement between the Participant and   the Company, the Participant will not be entitled to any compensation for any   losses suffered due to the fact that participation in the Plan is terminated.
  
	
  
 
  	
  
 
  	
  
 
  
	
   
  	
  
 
  	
  
(ii)     The grant   of Options is under no circumstances to be considered as a guarantee for   continuation of the employment relationship between the Participant and the   Company.
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
e)
  	
  
Severability
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
 
  	
  
In the event   that any one or more of the provision of this Plan shall for any reason be   held by any court of competent jurisdiction to be void, illegal or   unenforceable in any respect, such invalidity, illegality or unenforceability   shall not affect any other provision of this Plan and such invalid, illegal   or unenforceable provision shall be reformed and construed so that it will be   valid, legal and enforceable to the maximum extent permitted by law.
  
	
  
 
  	
  
 
  	
  
 
  
	
  11.
  	
  
Insider   Trading and Code of Conduct
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
The exercise   of Options by the Participants must comply with the applicable regulations,   including insider trading regulations.
  
	
  
 
  	
  
 
  
	
  
 
  	
  
The Board is   authorised to refuse the exercise of Options, if the Board has reasons to   believe, at its sole discretion, that such exercise would breach such   regulations, including any regulations issued by the Company to prevent   insider trading operations.
  
	
  
 
  	
  
 
  
	
  
 
  	
  
The Code of Conduct and Securities Trading Policy attached to the   Award Agreement as Schedule 2 applies to the Participant, who hereby agrees   to be bound by its terms.
  

6

Plan approved by the Board of Directors of IsoTis SA  on November 27, 2002.

	
  
 
  	
  
 
  	
  
IsoTis SA
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
 
  	
  
 
  
	
  
Read and approved on __________________
  	
  
 
  	
  
 
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
 
  	
  
The Participant
  
	
   
  	
   
  	
   
  
	
   
  	
   
  	
   
  
	
   
  	
   
  	
  

  

7

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00102-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00102-of-00352.parquet"}]]