Document:

Second Amendment to License and Collaboration Agreement

 Execution Version 

Exhibit 10.93 

SECOND AMENDMENT TO THE 
 LICENSE AND COLLABORATION AGREEMENT 
 This Second
Amendment to the License and Collaboration Agreement (this “Second Amendment”) is made as of July 1, 2011 (the “Second Amendment Effective Date”), by and among Gilead Sciences, Inc., a corporation organized and
existing under the laws of the State of Delaware and having its principal place of business at 333 Lakeside Drive, Foster City, California 94404 (“Gilead Parent”), Gilead Sciences Limited, a corporation existing under the laws of
Ireland and wholly-owned subsidiary of Gilead Parent having its principal place of business at IDA Business & Technology Park, Carrigtohill, Co. Cork, Ireland (“Gilead Sub” and, collectively with Gilead Parent,
“Gilead”) and Tibotec Pharmaceuticals, a company organized and existing under the laws of Ireland, having its principal place of business at Eastgate Village, Eastgate, Little Island, County Cork, Ireland
(“Tibotec”). Each of Gilead and Tibotec is sometimes referred to individually herein as a “Party” and collectively as the “Parties.” 

WHEREAS, Gilead and Tibotec previously entered into that certain License and Collaboration Agreement, dated as of
July 16, 2009 (as amended from time to time, the “Agreement”); 
 WHEREAS, Gilead and
Tibotec previously entered into that certain First Amendment to the Agreement, dated as of September 14, 2010 (the “First Amendment”); and 

WHEREAS, Gilead and Tibotec desire to amend the Agreement to provide for the sale of Combination Product in certain
additional countries and modify and simplify the payment and distribution terms in such countries as between the Parties. 
 NOW THEREFORE, in consideration of the premises and the mutual covenants set forth herein and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the
Parties agree to amend the Agreement as follows: 
 SECTION 1.   Additional
Definitions. The following new definitions shall be inserted into the Agreement: 
 1.1    
“Branded Region B/C Combination Product” shall mean any Territory Combination Product that is Manufactured by or on behalf of Gilead or its Affiliates (or by or on behalf of Tibotec or its Affiliates pursuant to Section 8.5) in
accordance with the Branded Region B/C Combination Product specifications set forth in Annex Z (including the tablet color and shape set forth therein) which specifications describe a product intended by the Parties to be sold or otherwise
Distributed (or Manufactured for sale or other Distribution) exclusively in Region B or Region C. 

  
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AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 Execution Version 

1.2     “Branded Region B/C Combination Product Trade Dress” shall have the meaning set forth in
Section 6.8. 
 1.3     “Existing Region” shall mean the Territory excluding Region A,
Region B and Region C. 
 1.4     “Expanded Existing Region” shall mean the Existing
Region, including Mexico and Argentina. 
 1.5     “Final TCP Invoice” shall mean an
invoice or credit note issued to Tibotec or its designated Affiliate in accordance with this Agreement at the end of the applicable Calendar Year for Triggering Sales of Territory Combination Product with respect to the Tibotec Countries as set
forth in Annex BB. 
 1.6     “Final TMC278 Invoice” shall mean the invoice or credit note
issued to Gilead or its designated Affiliate in accordance with this Agreement at the end of the applicable Calendar Year for the Regional TMC278 Annual True-Up with respect to the Gilead Countries as set forth in Annex N. 

1.7     “Generic Exception” shall have the meaning set forth in Section 17.2(a). 

1.8     “Generic Manufacturing Agreement” shall mean any agreement between Tibotec or a Tibotec
Affiliate and a Gilead Licensee pursuant to which Tibotec or its Affiliates grants such Gilead Licensee the right under intellectual property Controlled by Tibotec and its Affiliates to Manufacture or commercialize Generic Region C Combination
Product. 
 1.9     “Generic Region C Combination Product” shall mean any generic
Combination Product. For clarity, Generic Region C Combination Product does not constitute Territory Combination Product. 

1.10   “Gilead Licensee” shall mean, at a given time, any Third Party that is a party to an agreement with
Gilead or any of its Affiliates under which Gilead or such Affiliate has granted to such Third Party rights to Manufacture and sell TDF, FTC or both (as API or in the form of a generic product) in the Field in Region C. 

1.11   “Gilead Region C Know-How” shall mean any and all Gilead Know-How necessary to make the Generic Region
C Combination Product from TDF, FTC and TMC278. 
 1.12   “Interim TCP Invoice” shall mean the
invoice for Territory Combination Product issued to Tibotec or its designated Affiliate in accordance with this Agreement that is calculated based on the TCP Interim Supply Price with respect to the Tibotec Countries as set forth in Annex BB.

  
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AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 Execution Version 

1.13     “Joint Region C Know-How” shall mean any and all Joint Know-How necessary to make the
Generic Region C Combination Product from TDF, FTC and TMC278. 
 1.14     “Licensed Generic
Manufacturer” shall have the meaning set forth in Section 6.12(a). 
 1.15    
“Limited Region A” shall mean Region A, excluding Mexico and Argentina. 

1.16    “Major Market Combination Product” shall mean any Territory Combination Product that is
manufactured by Gilead in accordance with the Major Market Combination Product specifications set forth in under Annex Z which specifications describe a product intended by the Parties to be sold or otherwise Distributed (or Manufactured for sale or
other Distribution) in the Territory outside of Region B or Region C, which shall, for the avoidance of doubt, exclude any Region B/C Combination Product. 
 1.17     “Major Market Trade Dress” shall mean the tablet color, embossing and printing on the tablet, and the label, packaging and package insert for the Major Market
Combination Product, in each case that has been approved by the applicable Regulatory Authorities, from time-to-time. 

1.18     “Region A” shall mean those countries designated in Annex AA as Region A countries.

 1.19     “Region B” shall mean those countries designated in Annex AA as Region B
countries. 
 1.20     “Region B/C Combination Product” shall mean Generic Region C
Combination Product and Branded Region B/C Combination Product. 
 1.21     “Region C”
shall mean those countries designated in Annex AA as Region C countries. 
 1.22     “Revaluation
TCP Invoice” shall mean the invoice or credit note for revaluation of Interim TCP Invoices in accordance with Annex DD. 
 1.23     “TCP Invoice” shall mean an Interim TCP Invoice, Revaluation TCP Invoice or a Final TCP Invoice, as applicable. 

1.24     “Third Party Component Distributor” shall mean a Third Party distributor that
(a) purchases Truvada (or Viread and Emtriva in countries where Truvada is not sold) or the TMC278 Product, as applicable, from a Party or its Affiliates for distribution in a country in the Territory and (b) has the right to conduct the
marketing, promotion, distribution, selling and other activities for the commercialization of such product. 

  
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AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 Execution Version 

1.25     “Tibotec Licensee” shall mean, at a given time, any Third Party that is a party to an
agreement with Tibotec or any of its Affiliates under which Tibotec or such Affiliate has granted to such Third Party rights to Manufacture and sell 25 mg TMC278 in combination with 300 mg TDF and 200 mg FTC in the Field in Region C. 

SECTION 2.   Gilead and Tibotec Countries Definition. 

2.1     Section 1.100 of the Agreement is hereby replaced in its entirety as follows: “Gilead
Countries” shall mean all countries in the Territory, other than any Tibotec Countries, as set forth in Annex AA. 

2.2     Section 1.236 of the Agreement is hereby replaced in its entirety as follows: “Tibotec
Countries” shall mean those countries indicated as Tibotec Countries in Annex AA. 

SECTION 3.   Region Definition. Section 1.202 of the Agreement is hereby replaced in its
entirety as follows: 
 “Region” shall mean, as applicable, the Existing Region, Expanded Existing Region,
Limited Region A, Region A, Region B, Region C, Japan or Russia, or any combination of the foregoing, defined subdivision of the foregoing or defined grouping of subdivisions of the foregoing, as the case may be; provided, however, that
Region as used in Sections 19.5(d), 19.5(e), 19.6(d) and 19.6(e) shall mean either (a) the United States and Canada, or (b) all countries in the Territory other than the United States and Canada, as the case may be. 

SECTION 4.   Selling Party Definition. Section 1.214 of the Agreement is hereby replaced
in its entirety as follows: 
 “Selling Party” shall mean (a) Tibotec in the case of the Tibotec Countries
and (b) Gilead in the case of the Gilead Countries. 
 SECTION 5.   Specified Percentage
Definition. Section 1.219 of the Agreement is hereby replaced in its entirety as follows: 
 “Specified
Percentage” shall mean (a) in the case of all countries in the Territory other than the countries in [*], subject to adjustment, on a country-by-country basis, pursuant to Section 11.6, and (b) in the case of countries
in [*]. 
 SECTION 6.   Territory Definition. Section 1.227 of the
Agreement is hereby replaced in its entirety as follows: 
 “Territory” shall mean all countries of the world.

  
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AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 Execution Version 

SECTION 7.       Territory Combination Product Definition.
Section 1.228 of the Agreement is hereby replaced in its entirety as follows: 
 “Territory Combination
Product” shall mean any Combination Product sold or otherwise distributed (or Manufactured for sale or other distribution) pursuant to this Agreement or any Ancillary Agreement, excluding, for the avoidance of doubt, any Generic Region C
Combination Product. 
 SECTION 8.       Tibotec Distributor Agreement
Definition. Section 1.237 of the Agreement is hereby replaced in its entirety as follows: 
 “Tibotec
Distributor Agreement” shall mean, as applicable, Annex Z or any agreements entered into by Gilead and Tibotec, or their respective Affiliates which the Parties agree supersede Annex Z with respect to country(ies) in which Tibotec is the
Selling Party and pursuant to which Gilead sells the Territory Combination Product to Tibotec, in bulk or bottled form, for Distribution in one or more Tibotec Countries. 
 SECTION 9.       Access Agreement Removal.  
 Section 1.4 of the Agreement is hereby deleted in its entirety. 

SECTION 10.     Other Combination Product Clinical Trials. Section 3.2(b)(iii)
of the Agreement is hereby amended by deleting the text “or Japan” from the Section. 

SECTION 11.     Registration Plan Creation. Section 4.2(a) of the Agreement is
hereby amended by inserting the following sentence at the end of such Section: Within sixty (60) days after the Second Amendment Effective Date, the Parties shall update the Registration Plan to cover the countries in Region A, Region B and
Region C in which a Party or its applicable Affiliate or Third Party Distributor intends to launch the Branded Region B/C Combination Product. 

SECTION 12.     Product Information; Medical Affairs and Medical Communications. 

12.1     Section 5.1(a) of the Agreement is hereby amended by inserting the words “and Section 6.3(b)” following
the words “Section 5” in the first sentence. 
 12.2     Section 5.1(b) of the agreement is hereby amended by
inserting the words “Subject to Section 6.3(b),” at the beginning of the first sentence. 

SECTION 13.     Distribution Rights and Related Matters. Section 6.1 of the Agreement is hereby
replaced in its entirety as follows: 
 6.1      Tibotec Distribution Rights and Related Matters. 

  
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AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 Execution Version 

(a) General Restrictions on Distribution of Territory Combination Products. 

(i)    Major Market Combination Product. Each Party and its Affiliates (A) may and shall only sell, offer for
sale, or assist Third Parties in selling Major Market Combination Product in Region A for end use in the Field and in countries in Region A in which such Party is the Selling Party, and (B) shall not sell and shall prohibit its distributors and
their respective wholesalers and distributors (if any are permitted pursuant to this Agreement) from selling Major Market Combination Product in Region B or Region C or from assisting any Third Party in doing so. 

(ii)    Branded Region B/C Combination Products. Each Party and its Affiliates (A) may and shall only sell,
offer for sale, or assist Third Parties in selling Branded Region B/C Combination Product in Region B or Region C for end use in the Field and in countries in Region B or Region C in which such Party is the Selling Party, and (B) shall not sell
and shall prohibit its distributors and their respective wholesalers and distributors (if any are permitted pursuant to this Agreement) from selling a Branded Region B/C Combination Product outside of Region B or Region C or from assisting any Third
Party in doing so. 
 (iii)    Generic Region C Combination Products. Each Party and its Affiliates
(A) shall only sell, offer for sale, or assist Third Parties in selling Generic Region C Combination Product in Region C for end use in the Field, and (B) shall not sell and shall prohibit its distributors and their respective wholesalers
and distributors (if any are permitted pursuant to this Agreement) from selling a Generic Region C Combination Product outside of Region C or from assisting any Third Party in doing so. 

(b) Notification of Generic Sale for Region C. It is anticipated that Tibotec (or its Affiliates or Third Party Distributors) may
initially Distribute Branded Region B/C Combination Product in Region C where Tibotec is the Selling Party. If at any time Tibotec or any of its Affiliates or Third Party Distributors determines that it desires to sell Generic Region C Combination
Product in a Tibotec Country in Region C, Tibotec shall promptly provide advance notice to Gilead of such election and specify in which Tibotec Countries in Region C it intends to sell Generic Region C Combination Product. 

(c) Non-Region B/C Combination Product. Neither Party nor any of its Affiliates shall be permitted to Distribute any Combination
Product in Region C other than Region B/C Combination Product. 
 (d) Gilead Third Party Distributor Purchases in Region
C. Nothing in this Agreement shall prevent Gilead’s Third Party Distributors in Region C from purchasing Generic Region C Combination Product from a Licensed Generic Manufacturer and selling such Generic Region C Combination Product in
those Region C countries where Gilead is the Selling Party. 

  
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AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 Execution Version 
 SECTION 14.         Specific Commercialization Obligations. Section 6.2(b)(iii) of the Agreement is hereby amended as follows:

 14.1     Section 6.2(b)(iii) is amended by inserting the following sentence at the end of the Section:
“Notwithstanding anything contained herein to the contrary, the Parties may from time to time mutually agree in writing on adjustments to the number of Details set forth in Annex F.” 

SECTION 15.         Detailing Election. Section 6.3(a) of the Agreement is
hereby amended by replacing the word “Territory” in the first sentence with “Expanded Existing Region”. 

SECTION 16.         Other Promotion by Tibotec. Section 6.3(b) of the
Agreement is hereby replaced in its entirety as follows: 
 (b)     Tibotec Distribution Rights and Related Matters.

 (i)   For any country in the Expanded Existing Region, Tibotec and its Affiliates may not market or promote
(other than Detail) the Territory Combination Product, but may in connection with their activities relating to the TMC278 Product respond to unsolicited questions that they receive with respect to the Territory Combination Product. Gilead may elect
to provide Tibotec with an approved slide deck or other background materials for use in responding to such questions. In the event that Gilead does elect to provide such materials, Tibotec and its Affiliates shall respond to any unsolicited
questions that they receive with respect to the Territory Combination Product in a manner consistent with such materials (unless Tibotec or its applicable Affiliate believes in good faith that such materials are inconsistent with Applicable Law or
its corporate policies). 
 (ii)   For any country in Limited Region A, the non-Selling Party with respect to
such country may respond to unsolicited questions solely in accordance with Applicable Law and based solely upon the Product Label and Insert for the Territory Combination Product in such country in Limited Region A and any approved materials the
Selling Party provides to the non-Selling Party for responding to such questions in such country, which approved materials may be withdrawn from use by the Selling Party at any time. 

(iii)   For any country in Region B or Region C, the non-Selling Party with respect to such country and its Affiliates
shall not respond to any unsolicited question that they receive with respect to the Territory Combination Product and shall use reasonable efforts to refer any such unsolicited questions to the Selling Party for such country. 

  
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 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 Execution Version 

(iv) For clarity, for each of Mexico and Argentina, Tibotec may elect, in accordance with Section 6.3(a), to Detail the Territory
Combination Product, provided that it does so strictly in accordance with the restrictions and requirements applicable to [*]. 

SECTION 17.         Detailing of the TMC278 Product. Section 6.4 of the
Agreement is hereby amended by inserting the phrase “, excluding any countries in Region A, Region B or Region C,” following the word “Territory” in the first sentence. 
 SECTION 18.         Branded Region B/C Combination Product Trade Dress. Section 6.8 of the Agreement is hereby amended by:

 18.1     Changing all references to “Combination Product” in such Section to “Territory Combination
Product”; and 
 18.2     Inserting the following at the end of such Section: “All Branded Region B/C Combination
Products shall have a different tablet color and tablet design and packaging than the Major Market Combination Product. Without limitation of the foregoing provisions of this Section 6.8, Gilead shall designate such tablet color and design and
shall design the packaging for the Branded Region B/C Combination Product, which packaging (and only such packaging) shall be used by Tibotec and its Affiliates and Third Party Distributors (the “Branded Region B/C Combination Product Trade
Dress”); provided, however, that Tibotec shall modify such packaging as required to comply with local Applicable Law and shall translate such packaging to the local language as necessary. Tibotec shall notify Gilead and obtain
Gilead’s prior written approval of any such packaging modifications with respect to the Branded Region B/C Combination Products.” 

SECTION 19.         Licensed of Joint Technology to Generic Manufacturers.
Section 6.12 of the Agreement is hereby inserted as follows: 
 6.12     Generic Region C Combination Product
Licensed Manufacturers. 
 (a) Subject to the terms of this Agreement, notwithstanding Section 14.1(d) of this
Agreement, Tibotec shall have the right to license the Gilead Licensees under Tibotec’s interest in the Joint Technology and any intellectual property and other rights in and to TMC278 owned or otherwise Controlled by Tibotec and its
Affiliates, in each case, to Manufacture and otherwise Exploit Generic Region C Combination Products solely in Region C (or any countries therein) (each Gilead Licensee so licensed by Tibotec, a “Licensed Generic Manufacturer”). For
clarity, Tibotec and its Affiliates are not themselves licensed by Gilead to Exploit TDF or FTC (other than in the Territory Combination Product) and therefore shall not have the right to grant any licenses under Gilead’s intellectual property
with respect to TDF or FTC. 

  
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ACT OF 1934, AS AMENDED 

 Execution Version 

(b) Each Party (i) represents and warrants that as of the Second Amendment Effective Date it has provided the other Party with a
list of Tibotec Licensees or Gilead Licensees, as applicable, that is complete and accurate as of the Second Amendment Effective Date and each Party shall, from time to time, provide the other Party a written update of such list to reflect any
modifications to its Tibotec Licensees or Gilead Licensees, as the case may be and (ii) from time to time, as requested by the other Party, shall provide a true and correct copy of [*] of this Agreement. Notwithstanding anything to the
contrary hereunder or in any Ancillary Agreement, neither Gilead nor Tibotec shall be liable for, nor be obligated to indemnify, hold harmless or defend the other Party or any of its Indemnified Persons with respect to any act or omission of any
Gilead Licensee or Tibotec Licensee, respectively, and any Losses or Proceedings arising therefrom provided that such Party has complied with its obligations hereunder with respect to such Gilead Licensee or Tibotec Licensee. 

SECTION 20.         Trademark and Patent Lists for Region A, B and C.
Section 6.13 of the Agreement is hereby inserted as follows: 
 6.13     Updated Trademark and Patent Lists. For
the countries in Region A, Region B and Region C, at reasonable intervals, the Selling Party may request from the non-Selling Party updates to Annexes A and B to include the Patents and Trademarks covered thereby for such countries, in which case
the non-Selling Party shall provide such update for its applicable Patents and Trademarks within a reasonable time following such request. 

SECTION 21.         Technology Transfer; Generic Licensees. Section 6.14 of
the Agreement is hereby inserted as follows: 
 6.14     Technology Transfer Package. Upon the written request of
Tibotec, Gilead shall prepare a written technology transfer package of Gilead Region C Know-How and Joint Region C Know-How available to Gilead (the “Generic Technology Transfer Package”). If Tibotec notifies Gilead of any
[*] 
 SECTION 22.         Modified Pricing. Section 7.7 of
the Agreement is hereby inserted as follows: 
 7.7     Limited Region A, Region B and Region C Modified Pricing.
Notwithstanding anything in this Agreement to the contrary, the pricing and discounting provisions for Limited Region A, Region B and Region C shall be governed by the provisions set forth in Annex Y (and not the other provisions of this
Section 7 unless expressly provided for in Annex Y). 
 SECTION 23.        
Territory Combination Product Supply to Tibotec. Section 8.2 of the Agreement is hereby replaced in its entirety and Section 8.5 is added as follows: 

  
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AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 Execution Version 
 8.2     Territory Combination Product Supply to Tibotec. The supply of Territory Combination Product to Tibotec for Distribution in the Tibotec Countries and the Distribution of
such Territory Combination Product by Tibotec shall be governed by the terms of this Agreement, including those set forth in Annex Z. The terms set forth in Annex Z shall constitute the Tibotec Distribution Agreement for purposes of this Agreement.

 8.5     [*] 
 SECTION 24.         Retained Rights. Section 9.5 of the Agreement is hereby amended by inserting the following two
(2) sentences at the end of such Section “Notwithstanding anything contained in this Section 9.5, none of the licenses granted under this Agreement apply to Generic Region C Combination Product. Notwithstanding any exclusivity or
co-exclusivity granted in this Section 9, but subject to the terms of this Agreement, each Party and its Affiliates retains all rights under any intellectual property owned or Controlled by such Party or its Affiliates (other than Controlled as
a result of the licenses granted in this Section 9), including its interest in the Joint Technology, to exercise its rights under such Party’s Generic Exception.” 
 SECTION 25.         Section 10.4 and Annex J. A new Section 10.4(e) of the Agreement is hereby inserted as follows:

 (e)     Notwithstanding anything else in this Section 10.4 or Annex J, the provisions of this
Section 10.4 and Annex J do not apply to [*] 
 SECTION 26.        
Expired and Returned Product. Section 10.6 of the Agreement is hereby replaced in its entirety with the following: 
 10.6         Expired and Returned Product. 
 (a) Gilead Countries. 
 (i) If Gilead (or its applicable Affiliate) is unable to
sell any quantities of Territory Combination Product packaged and labeled for countries in the Territory in which Gilead is the Selling Party in its reasonable discretion on account of product expiry (or short remaining shelf-life, as applicable),
or such Combination Product is otherwise returned by a Customer (and such Customer is entitled to a credit in connection with such return pursuant to Gilead’s (or its Affiliate’s) applicable standard return policy (published and in effect
immediately prior to such return)) to Gilead (or its applicable Affiliate), and cannot be resold (any such Combination Product that cannot be so sold or is so returned and cannot be resold, “Gilead Expired/Short-Dated Product”),
then (A) Gilead shall destroy such Combination Product (which destruction shall be in accordance with Applicable Law), (B) within ten (10) Business Days following the end of each calendar month, Gilead shall notify Tibotec of the
quantity, if any, of Gilead Expired/Short-Dated 

  
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AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 Execution Version 
 Product designated, during such calendar month, for destruction (pursuant to Gilead’s standard operating procedures), and (C) with respect to any Gilead Expired/Short-Dated Product,
(1) notwithstanding anything in this Agreement or any Ancillary Agreement, the Manufacturing Fees that were incurred for any Gilead Expired/Short-Dated Product shall be borne, [*] 

(ii) Notwithstanding anything preceding in Section 10.6(a)(i), during the period of time when Major Market Combination Product or
Branded Region B/C Combination Product has [*] The Parties shall coordinate in good faith to determine the timing and mechanics for effecting the foregoing adjustments and payments. 

(b) Tibotec Countries. Subject to Section 2.2 of the Tibotec Distributor Agreement and Annex Z, Section 10.6(a)(i) shall
apply to (i) Tibotec as the Selling Party, mutatis mutandis, and (ii) any Territory Combination Product that was Delivered to Tibotec under the Tibotec Distributor Agreement, which Territory Combination Product Tibotec is [*]

 SECTION 27.         Taxes. Section 10.11 of the Agreement is
hereby replaced in its entirety with the following: 
 10.11   Tax. 

(a) Subject to Section 10.11(b), each Party shall be responsible for any and all sales, use, excise, value added, goods and services
and similar taxes and charges imposed with respect to any payments to such Party by the other Party pursuant to this Section 10, and each Party shall be responsible for any taxes (including any such taxes imposed by way of withholding) in the
nature of income or franchise taxes or based on or measured by gross or net income imposed with respect to its income. Subject to Section 10.11(b), each Party shall pay to the proper taxing authority any and all withholding taxes or similar
charges imposed by any governmental unit that are required to be withheld from any amounts due to the other Party pursuant to this Section 10, and proof of payment of such taxes or charges shall be secured and sent to such other Party as
evidence of such payment. All amounts withheld and paid by a Party pursuant to the immediately preceding sentence with respect to taxes for which the other Party is responsible pursuant to the first sentence of this Section 10.11 shall be paid
for the account of such other Party and deducted from the amounts due from the paying Party to such other Party pursuant to this Section 10. 
 (b) If Tibotec [*] 

SECTION 28.         Establishment/Adjustment of the Supply Prices.
Section 11.5 of the Agreement is hereby replaced in its entirety with the following: 

  
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ACT OF 1934, AS AMENDED 

 Execution Version 
 11.5     Establishment/Adjustment of the Supply Prices in the Tibotec Countries and Gilead Countries. 
 (a) TMC278. Subject to the other terms and conditions of this Agreement, the TMC278 Supply Agreement shall provide that, with respect to any quantity of Supplied TMC278 ultimately used in Combination
Product sold in the Territory, Tibotec shall issue, and Gilead shall pay, a Pre-Conversion Invoice and, solely in the case of the Gilead Countries if there is a Triggering Sale, a Post-Conversion Invoice in accordance with the terms and procedures
set forth on Annexes M and N such that Gilead pays to Tibotec (i) the Pre-Conversion Supply Price and the Post-Conversion Supply Price for such Supplied TMC278 in the case of the Gilead Countries and (ii) in all other cases, [*] On a
monthly basis, no later than the tenth (10th) Business Day after the end of each month, Gilead shall calculate the Post-Conversion Supply Price for such Supplied TMC278 corresponding to Combination Product for which Triggering Sales occurred in
Gilead Countries in such month in accordance with Annex N, and shall provide such Post-Conversion Supply Price to Tibotec. All Pre-Conversion Supply Prices and Post-Conversion Supply Prices shall be calculated in U.S. Dollars. For the avoidance of
doubt, to the extent the TMC278 Supply Agreement is inconsistent with Annex M and Annex N of this Agreement, as amended, the terms of Annex M and Annex N shall supersede the terms of the TMC278 Supply Agreement (including, for clarity, the
limitation in Annex M and Annex N that [*] 
 (b) Territory Combination Product. The issuance of invoices and payment terms for
Territory Combination Product sold by Gilead to Tibotec or its Affiliates shall be determined according to the provisions set forth in Annex BB. 
 SECTION 29.         Payment Terms for Region A, Region B and Region C. Section 11.6 of the Agreement is hereby amended by
inserting the following sentence at the end of the Section: “The provisions of this Section 11.6 shall not apply to any of the countries in Region A, Region B or Region C.” 
 SECTION 30.         Payment Term and Related Matters. Section 11.7(d) of the Agreement is hereby amended be inserting
“Solely with respect to the Expanded Existing Region and any Triggering Sales occurring therein,” at the beginning of the first sentence of the section. 
 SECTION 31.         Payment Terms for Region A, Region B and Region C. Section 11.7(e) of the Agreement is hereby replaced in
its entirety with the following: 
 11.7(e)         Notwithstanding anything else in this
Section 11.7, the payment terms for (i) Supplied TMC278 ultimately used in Combination Product sold in Region A, Region B and Region C are set forth in Annex M which, in the case of such Supplied TMC278, shall apply in lieu of the
provisions in this Section 11.7 and (ii) Territory Combination Product sold to Tibotec are set forth in Annex BB. 

  
 12 

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 Execution Version 
 SECTION 32.         A new Section 11.10 is added to the Agreement as follows: 
 11.10             The Parties agree that [*] 
 SECTION 33.         Audit. Sections 12.2(b) and (c) of the Agreement are hereby replaced in their entirety with the following:

 (b)     Mutually Agreed Audits. Unless otherwise agreed by the Parties in writing, the Parties shall engage an
Independent Accounting Expert to confirm, for each Calendar Year during the term of this Agreement, the accuracy of (i) any calculation by the Discount Committee, (ii) any pricing or discounting information provided to the Discount
Committee or to either Party by the other Party pursuant to Section 7.4 or Annex R, (iii) any information of a Party or its Affiliates that is required to determine that the DCPs provided by such Party comply with the terms of this
Agreement (including, for any Calendar Quarter up to and including the [*], (iv) the calculation of the TCP Final Supply Price for Major Market Combination Product Delivered for the Tibotec Countries [*] and (v) the
calculation of the Regional TMC278 Annual True-Up and the Post-Conversion Supply Price for Territory Combination Product with respect to the [*]; provided, however, that the foregoing shall not permit either Party to audit any Third
Party Component Distributor, such audit being permitted solely as and to the extent provided in Section 12.2(c). The Parties shall mutually agree in writing on the desired scope of such audit. The Independent Accounting Expert shall conduct
such other audits as mutually determined by the Parties in writing to confirm the accuracy of any financial data provided by or on behalf of either Party pursuant to Section 11.9. 
 (c)     Party Initiated Audits. Without limitation of Section 12.2(b), upon the request of either Party (the “Initiating Party”), the Independent Accounting
Expert shall audit the other Party (the “Audited Party”) and its applicable Affiliates to examine (subject to Section 12.2(d)) the books and records maintained by such Person pursuant to Section 12.1 to verify (i) any
amounts reimbursable by the auditing Party hereunder or under any Ancillary Agreement, (ii) the determination of any API Replacement Cost, (iii) in the case of Gilead as the Audited Party, the Manufacturing Fees, (iv) any calculations
required to be made pursuant to this Agreement, (v) any information or reports of such other Party provided pursuant to this Agreement, (vi) any information subject to the annual audit contemplated in Section 12.2(b), including the
accuracy of such information from time to time with respect to one or more Customers, (vii) the accuracy of any information provided by or on behalf of any Party pursuant to Section 11.9 to the other Party to the extent that such
information is used in any calculation hereunder with respect to the portion of costs and expenses borne, or revenue obtained, by the Initiating Party or any of its Affiliates hereunder or under any Ancillary Agreement and (viii) not more than
one (1) time per Calendar Year and solely with respect to [*] is used in the calculations set forth in the Annexes hereto during the audited period. The Initiating Party shall conduct an audit the scope of which is commensurate with the
underlying matters being audited as itemized in this Section 12.2(c) clauses (i) – (viii); provided, however, that any 

  
 13 

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 Execution Version 
 audits under clause (viii) shall be conducted solely by the Party that is party to the applicable agreement with such Third Party Component Distributor and in accordance with terms and conditions of
such agreement using the Independent Audit Expert or other mutually acceptable certified or charted accountant (in each case as permitted by the terms and conditions of such agreement) and the other Party shall only have the right to review the
results of such audit generated by the contracting Party and such Independent Audit Expert or accountant to the extent such audit results may be revealed pursuant to the applicable Third Party Component Distributor agreement; provided,
further, that this Section 12.2(c) shall not confer rights to any Party that exceed those rights set forth in the applicable agreement with such Third Party Component Distributor. 
 SECTION 34.         Consequences of Inaccurate DCPs and Component Prices. Section 12.2(e) of the Agreement is hereby replaced
in its entirety with the following: 
 (e)     Consequences of Inaccurate DCPs and Component Prices. 

(i)     NOTWITHSTANDING ANYTHING HEREIN TO THE CONTRARY, IN THE CASE OF THE EXPANDED EXISTING REGION (A) NEITHER PARTY SHALL
HAVE ANY LIABILITY TO THE OTHER PARTY FOR DAMAGES AND (B) NO ADJUSTMENTS SHALL BE MADE PURSUANT TO SECTION 12.2(i), IN EITHER CASE DUE TO THE PROVISION OF INACCURATE PRICING OR DISCOUNT INFORMATION TO THE DISCOUNT COMMITTEE (OR, FOR ANY
CALENDAR QUARTER UP TO AND INCLUDING THE [*]), EXCEPT TO THE EXTENT THAT SUCH BREACH OR LACK OF COMPLIANCE AROSE FROM THE GROSS NEGLIGENCE OR INTENTIONAL MISCONDUCT OF SUCH PARTY OR ITS AFFILIATES. 

(ii)     NOTWITHSTANDING ANYTHING HEREIN TO THE CONTRARY, IN THE CASE OF LIMITED REGION A, REGION B AND REGION C (A) THE SELLING
PARTY SHALL HAVE NO LIABILITY TO THE NON-SELLING PARTY FOR DAMAGES AND (B) [*]. 

SECTION 35.         Adjustments. Section 12.2(i) of the Agreement is hereby
replaced in its entirety with the following: 
 (i)     Adjustments. 

(i) The following shall apply to the Expanded Existing Region: Except as otherwise provided in Section 12.2(e), in the event that
the Independent Accounting Expert determines, pursuant to this Section 12.2, that any Party provided any inaccurate information, the Parties shall coordinate to recalculate any amounts due hereunder or under any Ancillary Agreement based on the
corrected data, as provided by the Independent Accounting Expert, and to make any payments that may be required to ensure that costs and expenses and revenues are shared in accordance with such 

  
 14 

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 Execution Version 
 recalculations (and the other applicable terms of this Agreement or such Ancillary Agreement); provided, however, that if either Party provided inaccurate pricing or discount information to the
Discount Committee (or, for any Calendar Quarter up to and including the [*] due to its or any of its Affiliates’ gross negligence or intentional misconduct, and such inaccurate information (or non-compliant DCP) resulted in a higher
selling price for the Combination Product than would have been permitted hereunder had the proper information (or DCP) been provided, then with respect to any Triggering Sales of Combination Product that were sold at a higher price that reflected
such inaccurate price information of such Party (or non-compliant DCP), the Parties’ respective revenue shares shall be adjusted as follows: the Selling Party shall determine, for the Units of Combination Product sold in such Triggering Sales
(the “At-Issue Units”), (a) [*] Other than the foregoing reapportionment, no other adjustments are intended to be made to account for, or as a result of, the Corrected Revenue Share (e.g., no adjustments to the Actual
Percentages). 
 (ii) The following shall apply to the Limited Region A, Region B and Region C: Except as otherwise provided in
Section 12.2(e), in the event that it is determined, pursuant to this Section 12.2, that any Party provided any inaccurate information, the Parties shall coordinate to recalculate any amounts due hereunder or under any Ancillary Agreement
based on the corrected data, as has been determined pursuant to this Section 12.2, and to make any payments that may be required to ensure that costs and expenses and revenues are shared in accordance with such recalculations (and the other
applicable terms of this Agreement or such Ancillary Agreement) 

SECTION 36.         Trademark Registration Costs. Section 14.6(c)(i) of the
Agreement is hereby replaced in its entirety with the following: 
 14.6(c)(i)       Registration. Subject
to the licenses granted in Section 9.4(c), the Parties agree that, as between Gilead and Tibotec and their respective Affiliates, Gilead (or its designee) shall own all right, title and interest in and to the Combination Product Trademarks.
Gilead (or its designee) shall have the sole right, at its sole expense, to search, clear, file, register, prosecute and maintain the Combination Product Trademarks anywhere in the world in the name of Gilead (or its designee); provided,
however, that [*] 
 SECTION 37.         Additional Representations,
Warranties and Covenants of Tibotec. 
 37.1     Section 17.2(a) of the Agreement is hereby amended by:

 (a) Deleting from the Section the following text “; provided, that this sentence shall not apply to Japan or any
of the countries in the Access Territory from and after [*] or for such longer period as Gilead is negotiating in good faith with Tibotec to enter into an agreement with respect to the Commercialization of the Combination Product in Japan or such
Access Territory country, as the case may be”; and 

  
 15 

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 Execution Version 

(b) Inserting in place of the deleted text the following text “; provided, however, that Tibotec and its Affiliates shall not
be precluded by the foregoing from granting licenses or other rights under their intellectual property to allow any generic manufacturer to Exploit, solely in and for sale in one or more countries in Region C, Combination Product; provided that the
agreement between such generic manufacturer and Tibotec or its applicable Affiliate granting such rights complies with Sections 17.2(d) and (e) (the right to grant such licenses to generic manufacturers described in this Section 17.2(a)
and the analogous right of Gilead under Section 17.3(c) are collectively, the ‘Generic Exception’).” 

37.2     A new Section 17.2(d) of the Agreement is hereby inserted as follows: 

Requirements for Tibotec Licensees. For (x) each Tibotec Licensee that enters into an agreement with Tibotec following the Second Amendment
Effective Date, Tibotec shall ensure such agreement includes, by way of a covenant or a condition on or limitation in the scope of the rights or licenses granted, each of the following provisions (or substantially similar or more restrictive
provisions) and (y) each current Tibotec Licensee, [*]: 
 (i) All Generic Region C Combination Product
manufactured by the Tibotec Licensees shall only be manufactured in facilities located in Region C or, at Tibotec’s discretion, a subset of countries contained within Region C. 

(ii) The Tibotec Licensee shall not sell and shall prohibit its Affiliates, distributors and their respective wholesalers and
distributors from selling any Generic Region C Combination Product outside of Region C or from assisting any Third Party in doing so. 
 (iii) The Tibotec Licensee shall use a trade dress for the Generic Region C Combination Product that has a tablet color, embossing and printing on the tablet and packaging that is sufficiently different
than both the Major Market Trade Dress and the Branded Region B/C Trade Dress so that there will be no likelihood of confusion. Tibotec shall review and approve exemplars of each Generic Region C Combination Product to be Manufactured by the Tibotec
Licensees to ensure compliance with this subsection. 
 37.3     A new Section 17.2(e) of the Agreement is hereby
inserted as follows: 
 Tibotec shall as soon as reasonably possible, and [*] 

  
 16 

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 Execution Version 
 SECTION 38.         Additional Representations, Warranties and Covenants of Gilead. 

38.1     Section 17.3(c) of the Agreement is hereby amended by: 

(a) Deleting from the Section the following text “; provided, that this sentence shall not apply to Japan or any of the
countries in the Access Territory from and after [*] or for such longer period as Gilead is negotiating in good faith with Tibotec to enter into an agreement with respect to the Commercialization of the Combination Product in Japan or such
Access Territory country, as the case may be”; and 
 (b) Inserting in place of the deleted text the following text “;
provided, however, that Gilead and its Affiliates shall not be precluded by the foregoing from granting licenses or other rights under their intellectual property to allow any generic manufacturer to Exploit, solely in and for sale in one or
more countries in Region C, Combination Product or Derivative Combination Product, provided that the agreement between such generic manufacturer and Gilead or its applicable Affiliate granting such rights complies with Sections 17.3(d) and (e).

 38.2     A new Section 17.3(d) of the Agreement is hereby inserted as follows: 

Requirements for Gilead Licensees. For (x) each Gilead Licensee that enters into an agreement with Gilead following the Second
Amendment Effective Date, Gilead shall ensure such agreement includes, by way of a covenant or a condition on or limitation in the scope of the rights or licenses granted, each of the following provisions (or substantially similar or more
restrictive provisions) and (y) each current Gilead Licensee, [*]: 

(i)         All Generic Region C Combination Product manufactured by the Gilead Licensees shall
only be manufactured in facilities located in Region C or, at Gilead’s discretion, a subset of countries contained within Region C. 
 (ii)        The Gilead Licensee shall not sell and shall prohibit its Affiliates, distributors and their respective wholesalers and distributors from selling any
Generic Region C Combination Product outside of Region C or from assisting any Third Party in doing so.

(iii)       The Gilead Licensee shall use a trade dress for the Generic Region C Combination Product
that has a tablet color, embossing and printing on the tablet and packaging that is sufficiently different than both the Major Market Trade Dress and the Branded Region B/C Trade Dress so that there will be no likelihood of confusion. Gilead
shall review and approve exemplars of each Generic Region C Combination Product to be Manufactured by the Gilead Licensees to ensure compliance with this subsection. 

  
 17 

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 Execution Version 
 38.3     A new Section 17.3(e) of the Agreement is hereby inserted as follows: 
 17.3(e)         Gilead shall as soon as reasonably possible, and [*] 
 SECTION 39.         Consequences of Termination. 
 Section 19.6(d)(vi) is hereby amended by inserting “, Annex Y” following the words “Section 7”. 
 SECTION 40.         Survival. Section 19.7(b) of the Agreement is hereby amended and replaced in its entirety with the
following: 
 19.7(b)         Without limiting anything contained in Section 19.6, in the event of
any termination of this Agreement for any reason, this Section 19.7 and Sections 1, 2.4, 3.4, 3.6 , 4.5, 6.1(a)(i), 6.1(a)(ii), 7 (to the extent relating to the calculation of the Parties’ respective share of revenue from the sale of the
Territory Combination Product that contains Supplied TMC278 shipped to Gilead (or its Affiliate) in the Expanded Existing Region during the term of this Agreement), 7.2(a) through (c) (to the extent relating to preventing the unauthorized use
and disclosure of a Party’s Territory Pricing Information), 7.4(c), 7.4(g), 8 (to the extent relating to payment by Gilead to Tibotec for TMC278 API shipped to Gilead (or its Affiliate) during the term of this Agreement), 9.1(a)(iii),
9.1(b)(ii), 9.3(c) (to the extent relating to 9.1(a)(iii) and 9.1(b)(ii)), 9.4(d), 9.5 (only the first sentence and the last two sentences),10.2, 10.3 (solely with respect to any adjustments to the payment obligations that have accrued prior to the
effective date of termination), 10.5 through 10.11, 10.12 (solely with respect to any royalties payable with respect to Territory Combination Product sold by the Selling Party or its Affiliates during the period in which Tibotec is supplying
Supplied TMC278 under the TMC278 Supply Agreement), 11.1, 11.5 through 11.7 (to the extent relating to payment by Gilead to Tibotec for TMC278 API shipped to Gilead (or its Affiliate) or relating to payment by Tibotec to Gilead for Territory
Combination Product Delivered to Tibotec (or its Affiliate), in each case during the term of this Agreement) during the term of this Agreement), 11.8 (solely for purposes of a final yield adjustment), 11.9 (solely for the purposes of final
calculations under this Agreement, 11.10 (solely for the purposes of final calculations under this Agreement), 12, 13 (to the extent the matters described therein are reasonably likely to affect the Territory Combination Product), 14.1, 14.3,
14.4(d) and (f), 14.5 (other than the last sentence of 14.5), 14.6(a) through (c)(i), 15, 16.3 (solely as the matters prohibited therein relate to this Agreement), 17 (solely with respect to the representations and not with respect to any covenants
set forth therein), 17.4, 18, 19.6, 20.1 through 20.15 and the Annexes to the extent applicable to the other surviving terms of this Agreement, shall survive such termination (with respect to the terminated Region, if applicable). For the avoidance
of doubt, the survival of certain terms of Annex Z are set forth in Annez Z. 

  
 18 

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 Execution Version 
 SECTION 41.         Annex M and N. Each of Annexes I, L, M, N, Q, R and Y are hereby replaced in their entirety with the attached
Exhibits I, L, M, N, Q, R and Y, respectively. 
 SECTION 42.         Annex
Y: Region A, Region C and Region B Alternate Pricing and Discount Rules. Annex Y of the Agreement is hereby inserted with the attached Exhibit Y. 
 SECTION 43.         Annex Z: Combination Product Supply to Tibotec. Annex Z of the Agreement is hereby inserted with the
attached Exhibit Z. 
 SECTION 44.         Annex AA: Selling Party
and Regions. Annex AA of the Agreement is hereby inserted with the attached Exhibit AA. 

SECTION 45.         Annex BB: Invoices and Payment Terms for Tibotec
Countries. Annex BB of the Agreement is hereby inserted with the attached Exhibit BB. 

SECTION 46.         Annex CC: Exchange Rates and Currency Conversion True-Up
Principles. Annex CC of the Agreement is hereby inserted with the attached Exhibit CC. 

SECTION 47.         Annex DD: Calendar Year End Revaluation TCP
Invoices. Annex DD of the Agreement is hereby inserted with the attached Exhibit DD. 

SECTION 48.         Definitions. All capitalized terms used, but not defined, in
this Second Amendment shall have their respective meanings set forth in the Agreement. 

SECTION 49.         Construction. The principles set forth in Section 20.12
of the Agreement shall apply to this Second Amendment. 
 SECTION 50.        
Effective Date; Incorporation of Terms; Continuing Effect. This Second Amendment shall be deemed effective for all purposes as of the Second Amendment Effective Date. The amendment set forth in this Second Amendment shall be deemed to
be incorporated in, and made a part of, the Agreement, and the Agreement, the First Amendment and this Second Amendment shall be read, taken and construed as one and the same agreement (including with respect to the provisions set forth in
Section 20 (Miscellaneous) of the Agreement which shall, as applicable, be deemed to apply to this Second Amendment (including with respect to the governing law). Except as otherwise expressly amended by this Second Amendment, the Agreement
shall remain in full force and effect in accordance with its terms and conditions. 

SECTION 51.         Counterparts. This Second Amendment may be executed in any
number of counterparts, each of which shall be deemed to be an original, and all of which, taken together, shall constitute one and the same instrument. 

  
 19 

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 Execution Version 

[Remainder of page intentionally left blank] 

  
 20 

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 IN WITNESS WHEREOF, the parties, intending to be bound, have caused this Second Amendment to
be executed on their behalf by their duly authorized agent as of the day and year first above written. 
  

			
	TIBOTEC PHARMACEUTICALS
		
	 By:
	 	 /s/ Margaret Dunlea

		 	Name: Margaret Dunlea
		 	Title: Managing Director
		
	 By:
	 	 /s/ Carol Leland

		 	Name: Carol Leland
		 	Title: Director

  
 Signature
Page to Second Amendment 

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

			
	 GILEAD SCIENCES, INC.

		
	 By:
	 	 /s/ John F. Milligan

		 	Name: John F. Milligan, Ph.D.
		 	Title: President and Chief Operating Officer
	
	 GILEAD SCIENCES LIMITED

		
	 By:
	 	 /s/ John F. Milligan

		 	Name: John F. Milligan, Ph.D.
		 	Title: Director

  
 Signature
Page to Second Amendment 

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 Execution Version 
 I.       Annex I: Calculation of Actual Percentages 

II.      Annex L: Annual Adjustments to Account for Actual Yield 

III.      Annex M: Payment Terms for TMC278 Invoices 
 IV.      Annex N: Post-Conversion Supply Price 

V.    Annex Q: Additional Financial Reporting 
 VI.      Annex R: Discount Rules and Related Matters 

VII.      Annex Y: Limited Region A, Region B and Region C Pricing and Discounts 

VIII.      Annex Z: Territory Combination Product Supply to Tibotec 

IX.      Annex AA: Selling Party and Country List for Region A, Region B and Region C 

X.      Annex BB: Invoice and Payment Terms for Territory Combination Product in Tibotec Countries 

XI.      Annex CC: Exchange Rates and Currency Conversion True-Up Principles 

XII.      Annex DD: Calendar Year End Invoice Adjustment for Tibotec Countries 

 

  

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

	I.	Annex I: Calculation of Actual Percentages 

 Capitalized terms not defined in this Annex shall have the meanings set forth in the agreement to which this Annex is attached (the “Agreement”). 

For each Calendar Year, (a) an actual percentage for each Party shall be established for the Territory as a whole (each an “Actual
Percentage”) in accordance with this Annex I and (b) an actual percentage for each Party shall be established on a Regional basis (as described below) in accordance with this Annex I (each a “Regional Actual
Percentage”). 
 For each Calendar Year, up to and including the Calendar Year prior to the Calendar Year in which the first Launch of
the Territory Combination Product in the Territory occurs, the Actual Percentage of Gilead shall equal the Working Percentage of Gilead for such Calendar Year and the Actual Percentage of Tibotec shall equal the Working Percentage of Tibotec for
such Calendar Year and for such period each Regional Actual Percentage of each Party shall equal the Actual Percentage of such Party. 
 For
each Calendar Year from and after the Calendar Year in which the first Launch of the Combination Product in the Territory occurs: 
  

	 	A.	Territory-Wide Percentages. 

 For a given
Calendar Year, the Actual Percentage of Tibotec shall equal [*]. The Actual Percentage of Gilead shall equal one hundred percent (100%) less the Actual Percentage of Tibotec for such Calendar Year, i.e.: 

 

	 	    	100% - Actual Percentage of Tibotec for such Calendar Year 

 The Actual Percentages shall be calculated by Gilead and notified to Tibotec no later than January 31st of such Calendar Year. 

 

	 	B.	Regional Percentages 

  

	 	B.1.	    Expanded Existing Region 

 The Regional Actual Percentage of Tibotec for the Expanded Existing Region shall equal [*] 
 [*] 
 [*] 

  
 Annex I - 1

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 The Regional Actual Percentage of Gilead for the Expanded Existing Region shall equal one hundred percent
(100%) less the Regional Actual Percentage of Tibotec for such Region for such Calendar Year, i.e.: 
  

	 	    	100% - Regional Actual Percentage of Tibotec for such Calendar Year 

 Such Regional Actual Percentages shall be calculated by Gilead and notified to Tibotec no later than January 31st of such Calendar Year. 

 

	 	B.2.	    Limited Region A, Region B and Region C. 

 For each of the Limited Region A, Region B and Region C, the Regional Actual Percentage [*] 

  
 Annex I - 2

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

	
	 An example of the calculation of the Actual Percentages and Regional Actual Percentages as described above, provided for illustrative
purposes only, is set forth below.
 [*]

  
 Annex I - 3

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

	II.	Annex L: Annual Adjustments to Account for Actual Yield 

 Capitalized terms not defined in this Annex shall have the meanings set forth in the agreement to which this Annex is attached (the “Agreement”). 

 

	1.	At the end of each Calendar Year, Gilead shall determine [*] Gilead shall use reasonable efforts to provide such determinations to Tibotec by February 15
after the end of the applicable Calendar Year and shall provide such determinations no later than March 1 after the end of such Calendar Year. 

  

	2.	For each Calendar Year, no later than thirty (30) days after the applicable notification is provided pursuant to Paragraph 1 of this Annex L, (a) [*] 

  

	3.	For clarification, there shall be [*] 

An example of the calculation of the Quantity Differential and associated Calendar Year-end balance sheet adjustments pursuant to paragraph 2 above (as
if it were a single Region), provided for illustrative purposes only, is attached below. 

  
 Annex L - 1

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 [*] 

  
 Annex L - 2

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

	III.	Annex M: Payment Terms for TMC278 Invoices 

 Capitalized terms not defined in this Annex shall have the meanings set forth in the agreement to which this Annex is attached (the “Agreement”). The payment terms for each of the
Regions, for the applicable Party are as follow: 
  

	 	A.	Expanded Existing Region 

 For the
avoidance of doubt, references to the Region in this Section A are deemed to mean the Expanded Existing Region. 
  

	 	A.1.	    Determination of the Annual Forecast Payment Term 

 No later than November 15th of each Calendar Year (in conjunction with the establishment of the Pre-Conversion Supply Price), Gilead shall propose, for the upcoming Calendar Year with
respect to the Gilead Countries of the Region a payment term for the payment of TMC278 Invoices (the “Annual Forecast Payment Term”) in the Region. Gilead shall provide Tibotec with a basis for its
proposed payment term, which shall reflect [*] 
 In the event that agreement on the Annual Forecast Payment
Term for the Gilead Countries in the Region cannot be reached by the Parties for a given Calendar Year by the commencement of such Calendar Year, the Annual Forecast Payment Term for such Calendar Year shall be [*] (the “Annual
Default Payment Term”). Gilead shall calculate and promptly notify Tibotec of the Annual Default Payment Term for the Region. 
 The
Default Payment Terms and the TPD Default Payment Terms shall be determined as follows for the Region: 
  

	 	1)	On a country-by-country basis, for each Gilead Country [*] (each a “Default Payment Term”). Gilead shall promptly notify Tibotec of the Default
Payment Term for each applicable country, once calculated. 

  

	 	2)	On a country-by-country basis, for each Gilead Country [*] (each a “TPD Default Payment Term”). 

 

	 	A.2.	    Deviation from Annual Forecast Payment Term. 

 On a quarterly basis for the Region, Gilead shall calculate and report to Tibotec [*] 
  

	 	A.3.	    Payment Terms 

  

	 	    a)	TMC278 Invoices. 

  
 Annex M - 1

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 For any Triggering Sales of Territory Combination Product that occur in a given calendar month in the
Region, any corresponding (as determined below) TMC278 Invoices (or portions thereof) shall be due [*] 
 [*] 

  
 Annex M - 2

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

	 	B.	Limited Region A Gilead Countries 

[*] 
 An example of the calculation of
the payment term with respect to the Gilead Countries in Limited Region A is included below: 

  
 Annex M - 3

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

	
	[*]

  
 Annex M - 4

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

	 	C.	Region B and Region C Gilead Countries 

The term “Region” as used in this Section C shall refer to the Gilead Countries in both Region B and Region C collectively. [*] 

  

	 	D.	Region A, Region B and Region C Tibotec Countries 

 For a given month, for any (a) Triggering Sales with respect to Territory Combination Product sold under an Interim TCP Invoice for Region A Tibotec Countries; or (b) Delivery (as defined in
Annex Z) of Territory Combination Product to Tibotec for Region B or Region C Tibotec Countries under an Interim TCP Invoice, Gilead shall establish due dates for the Pre-Conversion Invoices corresponding to such Interim TCP Invoice [*].

  
 Annex M - 5

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

	IV.	Annex N: Post-Conversion Supply Price 

 Capitalized terms not defined in this Annex shall have the meanings set forth in the agreement to which this Annex is attached (the “Agreement”). The Post-Conversion Supply Price for the
applicable Region and Selling Party shall be as follows: 
  

	 	A.	The Expanded Existing Region 

 For
purposes of this Section A, Region shall mean the Expanded Existing Region. The Post-Conversion Supply Price [*] 

  
 Annex N - 1

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

	
	 An example of the calculation of the Post-Conversion Supply Price and the Additional Supply Price, provided for
illustrative purposes only, is set forth below.
  

[*]

  
 Annex N - 2

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

	
	 An example of the revenue share report for the United States provided for illustrative purposes only, is set forth below.

 
 [*]

  
 Annex N - 3

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

	 	B.	Tibotec Countries 

 For the avoidance of
doubt, [*] 
  

	 	C.	Gilead Countries in Limited Region A, Region B and Region C 

 The term “Region” as used in this Section C shall refer to (i) the Gilead Countries in Limited Region A and (ii) the Gilead Countries in both Region B and Region C collectively. For
the avoidance of doubt, [*] 
  

	 	C.1.	    Post-Conversion Supply Price 

 The Post-Conversion Supply Price for a given Calendar Year (per kilogram of Supplied TMC278) with respect to the applicable Region shall equal: 

[*] 
 An example of the
calculation of the Post-Conversion Supply Price based on certain estimates with respect to TMC278 in the Gilead Countries in the Limited Region A is included below. 

  
 Annex N - 4

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

	
	[*]

  
 Annex N - 5

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

	 	C.2.	    Regional TMC278 Annual True-Up 

 The following Regional TMC278 Annual True-Up shall be calculated [*] 
 An example of the
calculation of Regional Actual Net Selling Price and the Regional TMC278 Annual True-Up in the Limited Region A is included below. 

  
 Annex N - 6

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

	
	[*]

  
 Annex N - 7

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

	V.	Annex Q: Additional Financial Reporting 

 Capitalized terms used in this Annex and not defined herein shall have the meaning set forth in the agreement to which this Annex is attached (the “Agreement”). Section references used in
this Annex shall refer to Sections in the Agreement except as otherwise provided. 
 I. Review of Calculations. Without
limitation of a Party’s audit rights under Sections 12.2(b) and (c) of the Agreement, each Party may review any calculation provided by the other Party under this Annex Q with respect to the Limited Region A, Region B and Region C. If the
reviewing Party disagrees with the other Party’s calculations, the reviewing Party shall promptly notify the other Party and the Parties’ respective finance representatives shall confer to discuss such disagreement. If they are unable to
resolve such dispute within ten (10) Business Days, to the extent such dispute regards the calculation itself (rather than a dispute regarding an interpretation of the Agreement (including this Annex or any other Annexes) or those matters
covered by Section 12.2(b) or (c)), then the reviewing Party may refer such dispute to an Independent Accounting Expert. The determination of such Independent Accounting Expert shall be deemed binding upon the Parties absent an agreement to the
contrary. For clarity, any dispute regarding the interpretation of the Agreement (including this Annex or any other Annexes) shall be subject to the dispute resolution provisions set forth in the Agreement. For the avoidance of doubt, this provision
is intended to apply only to review of the calculations performed pursuant to this Annex Q, and shall not entitle either Party to audit the underlying information utilized in such calculations, which audit right is exclusively provided pursuant to
Section 12.2(b) and (c) of the Agreement. 
 II. Expanded Existing Region. This Section II applies only
with respect to the Expanded Existing Region. The Parties shall exchange information as follows: 
 Each Party shall provide the
other Party with the following information at the times set forth below. Reporting pursuant to Section II of this Annex Q shall be on a country-by-country basis and, where appropriate in light of the calculations to be made under the Agreement or
any Ancillary Agreements, in the aggregate for all countries reported by the applicable Party in the Expanded Existing Region. Furthermore, to the extent applicable to the reporting contemplated in Section II of this Annex Q, the Parties shall
coordinate in good faith to establish categories into which the reporting Party may group Customers based on discounts and other factors deemed relevant by the Parties (“Customer Groups”) in order to limit the level of
administrative burden to the Selling Party, and such Customer Groups may change from time to time as the result of changes in Customers’ respective discounts or changes in such other factors. Once agreed by the Parties, such Customer Groups may
be used by Gilead for purposes of determining the Post-Conversion Supply Price pursuant to Annex N for the Expanded Existing Region. 
 [*]

  
 Annex Q - 1

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

	VI.	Annex R: Discount Rules and Related Matters 

 Capitalized terms not defined in this Annex shall have the meanings set forth in the agreement to which this Annex is attached (the “Agreement”). “Representative” shall
mean, with respect to a Party, either the Business Representative or the Attorney Representative of such Party. 
 [*] 

  

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

	VII.	    Annex Y: Limited Region A, Region B and Region C Pricing and Discounts 

Capitalized terms not defined in this Annex shall have the meanings set forth in the agreement to which this Annex is attached (the
“Agreement”). 
  

	 	A.	Generally. 

 The provisions set forth in
this Annex Y shall apply to the pricing of Territory Combination Product sold by the Selling Party or any of its applicable Affiliates to any Third Party, including a Third Party Distributor, in any country outside the Expanded Existing Region. For
clarity, the Discount Committee described in Section 7 of the Agreements shall not govern the pricing activities under this Annex Y. 
  

	 	B.	Pricing Principles Outside the Expanded Existing Region. 

  

	 	1.	The Selling Party shall have discretion as to the price that it offers to sell the Territory Combination Product unless otherwise specifically provided in this Annex Y.
Except as otherwise agreed by the Parties in writing, with respect to any Price Approval Country, the Selling Party shall be responsible for managing the negotiation with the applicable authority(ies) in each such country in the Territory to obtain
and maintain pricing approval. 

	 	2.	Upon request of one Party, the other Party shall make available to such requesting Party, solely to the extent allowed by Applicable Law, such information Controlled by
such other Party and its Affiliates as is required in order to obtain pricing and reimbursement approvals for the Territory Combination Product. 

	 	3.	The following shall apply to Price Approval Countries in Limited Region A or Region B. If, following the Launch of the Territory Combination Product in a given Price
Approval Country, [*] 

	 	4.	As between the Parties (and their respective Affiliates), the Selling Party (and its Affiliates) (or its Third Party Distributor) shall have sole responsibility for
conducting pricing and discounting negotiations (and all other contracting matters) with respect to the Territory Combination Product with Customers in the applicable country in the Territory in accordance with this Annex Y.

	 	5.	Gilead and Tibotec shall each retain sole discretion with respect to price-setting and discounts for its respective Single Agent Products and Double Agent Product.
Notwithstanding the foregoing, [*]  

  
 Annex Y - 1

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

	 	C.	Disputes. 

 In the event that
interpretation or application of this Annex Y is necessary to implement the provisions of this Annex Y, the Alliance Managers shall discuss the matter and attempt to resolve the matter by consensus. 

To the extent any of the above procedures is not permitted by Applicable Law, the Parties shall promptly agree on alternative procedures to replace such
procedures. 

  
 Annex Y - 2

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

	VIII.	    Annex Z: Territory Combination Product Supply to Tibotec 

 [See Separate Document] 

  

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

	IX.	Annex AA: Selling Party and Country List for Region A, Region B and Region C 

 This list shall automatically include any country that is derived from the territory of a country listed below (for example, the independent country of Southern Sudan from Sudan). 

 

					
	Region A	  
	Country	  	Selling Party	 
	 Albania
	  	 	[*]	  
	 Argentina
	  	 	[*]	  
	 Bahrain
	  	 	[*]	  
	 Bosnia-Herzegovina
	  	 	[*]	  
	 Chile
	  	 	[*]	  
	 Colombia
	  	 	[*]	  
	 Costa Rica
	  	 	[*]	  
	 Hong Kong
	  	 	[*]	  
	 Israel
	  	 	[*]	  
	 Japan
	  	 	[*]	  
	 Kosovo
	  	 	[*]	  
	 Kuwait
	  	 	[*]	  
	 Lebanon
	  	 	[*]	  
	 Malaysia
	  	 	[*]	  
	 Mexico
	  	 	[*]	  
	 Montenegro
	  	 	[*]	  
	 Oman
	  	 	[*]	  
	 Qatar
	  	 	[*]	  
	 Russia
	  	 	[*]	  
	 Saudi Arabia
	  	 	[*]	  
	 Serbia
	  	 	[*]	  
	 Singapore
	  	 	[*]	  
	 South Korea
	  	 	[*]	  
	 Taiwan
	  	 	[*]	  
	 United Arab Emirates
	  	 	[*]	  
	 Uruguay
	  	 	[*]	  
	 Venezuela
	  	 	[*]	  

  
 Annex AA - 1

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

					
	Region B	  
	Country	  	Selling Party	 
	 Algeria
	  	 	[*]	  
	 Anguilla
	  	 	[*]	  
	 Armenia
	  	 	[*]	  
	 Aruba
	  	 	[*]	  
	 Azerbaijan
	  	 	[*]	  
	 Belarus
	  	 	[*]	  
	 British Virgin Islands
	  	 	[*]	  
	 China
	  	 	[*]	  
	 Ecuador
	  	 	[*]	  
	 Egypt
	  	 	[*]	  
	 El Salvador
	  	 	[*]	  
	 Fiji
	  	 	[*]	  
	 Georgia
	  	 	[*]	  
	 Iran
	  	 	[*]	  
	 Iraq
	  	 	[*]	  
	 Jordan
	  	 	[*]	  
	 Kazakhstan
	  	 	[*]	  
	 Korea, Dem. People’s Rep. of
	  	 	[*]	  
	 Libya
	  	 	[*]	  
	 Morocco
	  	 	[*]	  
	 Nauru
	  	 	[*]	  
	 Palau
	  	 	[*]	  
	 Panama
	  	 	[*]	  
	 Paraguay
	  	 	[*]	  
	 Peru
	  	 	[*]	  
	 Philippines
	  	 	[*]	  
	 Sri Lanka
	  	 	[*]	  
	 Tonga
	  	 	[*]	  
	 Tunisia
	  	 	[*]	  
	 Turkmenistan
	  	 	[*]	  
	 Turks and Caicos
	  	 	[*]	  
	 Ukraine
	  	 	[*]	  

  
 Annex AA - 2

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

					
	Region C	  
	Country	  	Selling Party	 
	 Afghanistan
	  	 	[*]	  
	 Angola
	  	 	[*]	  
	 Antigua and Barbuda
	  	 	[*]	  
	 Bahamas
	  	 	[*]	  
	 Bangladesh
	  	 	[*]	  
	 Barbados
	  	 	[*]	  
	 Belize
	  	 	[*]	  
	 Benin
	  	 	[*]	  
	 Bhutan
	  	 	[*]	  
	 Bolivia
	  	 	[*]	  
	 Botswana
	  	 	[*]	  
	 Burkina Faso
	  	 	[*]	  
	 Burundi
	  	 	[*]	  
	 Cambodia
	  	 	[*]	  
	 Cameroon
	  	 	[*]	  
	 Cape Verde
	  	 	[*]	  
	 Central African Republic
	  	 	[*]	  
	 Chad
	  	 	[*]	  
	 Comoros
	  	 	[*]	  
	 Congo
	  	 	[*]	  
	 Congo, Dem. Rep. of the
	  	 	[*]	  
	 Cote d’Ivoire
	  	 	[*]	  
	 Cuba
	  	 	[*]	  
	 Djibouti
	  	 	[*]	  
	 Dominica
	  	 	[*]	  
	 Dominican Republic
	  	 	[*]	  
	 Equatorial Guinea
	  	 	[*]	  
	 Eritrea
	  	 	[*]	  
	 Ethiopia
	  	 	[*]	  
	 Gabon
	  	 	[*]	  
	 Gambia
	  	 	[*]	  
	 Ghana
	  	 	[*]	  
	 Grenada
	  	 	[*]	  
	 Guatemala
	  	 	[*]	  
	 Guinea
	  	 	[*]	  
	 Guinea-Bissau
	  	 	[*]	  

  
 Annex AA - 3

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

					
	 Guyana
	  	 	[*]	  
	 Haiti
	  	 	[*]	  
	 Honduras
	  	 	[*]	  
	 India
	  	 	[*]	  
	 Indonesia
	  	 	[*]	  
	 Jamaica
	  	 	[*]	  
	 Kenya
	  	 	[*]	  
	 Kiribati
	  	 	[*]	  
	 Kyrgyzstan
	  	 	[*]	  
	 Lao, People’s Dem. Rep.
	  	 	[*]	  
	 Lesotho
	  	 	[*]	  
	 Liberia
	  	 	[*]	  
	 Madagascar
	  	 	[*]	  
	 Malawi
	  	 	[*]	  
	 Maldives
	  	 	[*]	  
	 Mali
	  	 	[*]	  
	 Mauritania
	  	 	[*]	  
	 Mauritius
	  	 	[*]	  
	 Moldova, Rep. of
	  	 	[*]	  
	 Mongolia
	  	 	[*]	  
	 Mozambique
	  	 	[*]	  
	 Myanmar
	  	 	[*]	  
	 Namibia
	  	 	[*]	  
	 Nepal
	  	 	[*]	  
	 Nicaragua
	  	 	[*]	  
	 Niger
	  	 	[*]	  
	 Nigeria
	  	 	[*]	  
	 Pakistan
	  	 	[*]	  
	 Papua New Guinea
	  	 	[*]	  
	 Rwanda
	  	 	[*]	  
	 Saint Kitts and Nevis
	  	 	[*]	  
	 Saint Lucia
	  	 	[*]	  
	 Saint Vincent and the Grenadines
	  	 	[*]	  
	 Samoa
	  	 	[*]	  
	 Sao Tome and Principe
	  	 	[*]	  
	 Senegal
	  	 	[*]	  
	 Seychelles
	  	 	[*]	  
	 Sierra Leone
	  	 	[*]	  
	 Solomon Islands
	  	 	[*]	  
	 Somalia
	  	 	[*]	  

  
 Annex AA - 4

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

					
	 South Africa
	  	 	[*]	  
	 Sudan
	  	 	[*]	  
	 Suriname
	  	 	[*]	  
	 Swaziland
	  	 	[*]	  
	 Syria
	  	 	[*]	  
	 Tajikistan
	  	 	[*]	  
	 Tanzania, U. Rep. of
	  	 	[*]	  
	 Thailand
	  	 	[*]	  
	 Timor-Leste
	  	 	[*]	  
	 Togo
	  	 	[*]	  
	 Trinidad and Tobago
	  	 	[*]	  
	 Tuvalu
	  	 	[*]	  
	 Uganda
	  	 	[*]	  
	 Uzbekistan
	  	 	[*]	  
	 Vanuatu
	  	 	[*]	  
	 Vietnam
	  	 	[*]	  
	 Yemen
	  	 	[*]	  
	 Zambia
	  	 	[*]	  
	 Zimbabwe
	  	 	[*]	  

  
 Annex AA - 5

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

	X.	Annex BB: Invoice and Payment Terms for Territory Combination Product in Tibotec Countries 

Capitalized terms not defined in this Annex shall have the meanings set forth in the agreement to which this Annex is attached (the
“Agreement”). 
 Gilead shall issue to Tibotec an Interim TCP Invoice upon shipment of Territory Combination Product pursuant
to the Tibotec Distributor Agreement. Each such Interim TCP Invoice shall state the invoiced amount and quantity of Territory Combination Product covered by such invoice. Tibotec shall pay each such Interim TCP Invoice in accordance with the payment
terms and calculations set forth in this Annex BB of the Agreement. 
 [*] 

 

	 	A.	Tibotec Country Combination Product Invoicing 

 All TCP Invoices shall be issued and paid in U.S. Dollars on the date set forth below. 
  

	 	A.1.	    Invoicing and Payment in Region A Tibotec Countries (excluding [*]) 

For purposes of this section the Tibotec Countries in Region A (excluding [*]) are collectively the “Region” for purposes of this
Section A.1, such that there shall be a single Average Tibotec Region Payment Term for all of the Tibotec Countries in Region A (excluding [*]). 
 [*] 
 An example of the calculation of the payment term with respect to the Tibotec
Countries in Region A is included below. 

  
 Annex BB - 1

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

	
	[*]

  
 Annex BB - 2

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

	 	A.2.	    Invoicing and Payment in [*] 

 In order that the Parties may determine the amount to be set forth on any invoice for Territory Combination Product Delivered to Tibotec [*] 

 

	 	B.	Tibotec Country Combination Product Interim Supply Price 

 [*] 
 An example of the calculation of the TCP Interim Supply Price with respect to
Territory Combination Product in Region A Tibotec Countries (excluding [*]) is included below. 

  
 Annex BB - 3

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

	
	[*]

  
 Annex BB - 4

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

	 	B.1.	    Region B and Region C Tibotec Countries 

 During a Calendar Year, Gilead shall supply each Unit of Branded Region B/C Combination Product to Tibotec or its designated Affiliate at the TCP Interim Supply Price calculated for the Region B and
Region C Tibotec Countries (collectively, the Tibotec Countries of Region B and Region C shall constitute a “Region” for purposes of this Section B.2) during such Calendar Year. 
 [*] 

  
 Annex BB - 5

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 [*] 

  
 Annex BB - 6

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 [*] 

  
 Annex BB - 7

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 [*] 

  
 Annex BB - 8

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

	 	C.	Tibotec Country Combination Product Annual True-Up 

  

	 	C.1.	    Region A Tibotec Countries Excluding [*] 

 Within ninety (90) days following the end of each Calendar Year, Gilead shall provide Tibotec with a Final TCP Invoice with respect to each Interim TCP Invoice (or portion thereof) for the Tibotec
Countries in Region A (excluding [*]) (collectively, the “Region” for purposes of this Section C.1). [*] 
 An example
of the calculation of the TCP Annual True-Up is included below. 

  
 Annex BB - 9

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

	
	[*]

  
 Annex BB - 10

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

	 	C.2.	    Region B and Region C Tibotec Countries 

 The following TCP Annual True-Up calculations shall be calculated collectively for the Tibotec Countries of Region B and Region C (which are collectively the “Region” for purposes of this
Section C.2) such that there shall be a single TCP Annual True-Up for Region B and Region C. 
 Within ninety (90) days following the end
of each Calendar Year, Gilead shall provide Tibotec with a Final TCP Invoice with respect to each Interim TCP Invoice (or portion thereof) for the Region. [*] 

  
 Annex BB - 11

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

	XI.	Annex CC: Exchange Rates and Currency Conversion True-Up Principles 

 Capitalized terms not defined in this Annex shall have the meanings set forth in the agreement to which this Annex is attached (the “Agreement”). 

 

	 	A.	Estimated Net Selling Price and TCP Interim Supply Price Currency Conversions 

 With respect to the calculation of the TMC278 Post-Conversion Supply Price in Annex N with respect to the Limited Region A, Region B and Region C and the TCP Interim Supply Price in Annex BB with respect
to the Tibotec Countries and the calculations associated therewith, the conversion of currency values used in such calculations with respect to a country from the local currency into U.S. Dollars shall be calculated utilizing the applicable
Intra-Year Conversion Rate for such country during such Calendar Year. 
 “Intra-Year Conversion Rate” shall mean, with respect
to a Calendar Year and a country, the daily exchange rate between the applicable country’s currency and U.S. Dollars reported by the Bloomberg Professional service application on the last Business Day during the month of October in the previous
Calendar Year. 
  

	 	B.	Regional TMC278 Annual True-Up and TCP Annual True-Up 

 Notwithstanding Section 10.9 of the Agreement, with respect to the calculation of the Regional TMC278 Annual True-Up in Annex N and the TCP Annual True-Up in Annex BB, the conversion of currency
values used in such calculations with respect to a country from the local currency into U.S. Dollars shall be calculated utilizing the applicable Final Year Conversion Rate for such country for such Calendar Year with respect to which the Regional
TMC278 Annual True-Up and TCP Annual True-Up, as applicable, is being calculated. 
 “Final Year Conversion Rate” shall mean,
with respect to a Calendar Year and a country, the weighted average of the applicable country’s Monthly Average Exchange Rate for each of the months in such Calendar Year, weighted by the corresponding Actual Unit Sales, as applicable, with
respect to such country for such calendar month. 
 “Monthly Average Exchange Rate” shall mean, with respect to a country and a
calendar month, the actual average daily exchange rate for such month for converting the applicable country’s currency into U.S. Dollars, as such rate is reported in Bloomberg Professional service application. 

“Actual Unit Sales” shall mean, with respect to a country and a calendar month, the actual number of Units of Territory Combination
Product for which a Triggering Sale by Gilead and its Affiliates or Tibotec and its Affiliates, as applicable, has occurred in such country for such calendar month. 

  
 Annex CC - 1

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 An example of the calculation of the Final Year Conversion Rate for the TCP Annual True-Up in the Tibotec
Countries is included below. 

  
 Annex CC - 2

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

	
	[*]

  
 Annex CC - 3

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

	XII.	    Annex DD: Calendar Year End Invoice Adjustment for Tibotec Countries 

For purposes of this Annex DD, “Region” shall be deemed to mean each of (a) Region A (excluding [*]), (b) Region B and Region
C collectively (such that there shall be one calculation for all Tibotec Countries in Region B and Region C), (c) [*] 
 An example of
the calculation of the Revaluation TCP Invoice with respect to the Tibotec Countries is included below. 

  
 Annex DD - 1

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 [*] 

  
 Annex DD - 2

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 Execution Version 

Annex Z: Territory Combination Product Supply to Tibotec 
 (this “Tibotec Distributor Agreement” or “TDA”) 
  

			
	 Provision
	 	 Term

 

	1    Defined Terms	 	 Capitalized terms used and not defined in
this TDA have the respective meanings assigned to them in the Collaboration Agreement. For clarity, this TDA shall be deemed part of the Collaboration Agreement. Unless otherwise indicated, all section cross-references in this TDA are to the
Sections of this TDA and not the Collaboration Agreement.
  

“Contract Manufacturer” or “CMO” shall mean any Third Party contract manufacturer with which (a) Gilead or its
Affiliates contracts for the Manufacture of Territory Combination Product to fulfill its obligations hereunder, or (b) Tibotec or its Affiliates contracts for the labeling, packaging, handling or storage of Territory Combination Product.

 
 “Gilead Manufacturer” shall mean a Person that Manufactures
Territory Combination Product supplied hereunder by or on behalf of Gilead and its Affiliates, whether it be Gilead, an Affiliate of Gilead or a Contract Manufacturer of Gilead (or an Affiliate of Gilead).

 
 “Supply Committee” shall have the meaning set forth in the TMC278
Supply Agreement.
  
 “Territory Combination Product
Specifications” shall mean the specifications for Major Market Combination Product and Branded Region B/C Combination Product, as applicable, in each case as provided by Gilead to Tibotec promptly following NDA approval in the United
States, as amended from time to time in accordance with this TDA.
  

“Tibotec Packager” shall mean a Person that packages or labels Territory Combination Product supplied hereunder by or on behalf of
Tibotec and its Affiliates, whether it be Tibotec, an Affiliate of Tibotec or a Contract Manufacturer of Tibotec (or an Affiliate of Tibotec).

 

	2    Supply of Territory Combination Product; Minimum Shelf Life	 	2.1        
Generally. Subject to the terms and conditions of the Collaboration Agreement, during the term of this TDA, Gilead shall sell to Tibotec, and Tibotec shall purchase exclusively from Gilead, pursuant to Firm Orders properly submitted to Gilead
hereunder, all of Tibotec’s requirements of Territory Combination Product in unlabeled bottles of Major Market Combination Product or Branded Region B/C Combination Product, as applicable, for use solely as permitted under the Collaboration
Agreement. The Supply Committee shall determine the commencement

  
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 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 Execution Version 

 

			
	 	 	 date for Manufacture and sale to Tibotec
under this TDA of Branded Region B/C Combination Product, including any required Manufacture of validation batches required by Applicable Law; provided that the Parties understand and agree that Gilead shall require [*]

 
 2.2        Minimum Shelf
Life.
  

2.2.1        [*]

 
 2.2.2         [*]
and for clarity Section 10.6(b) of the Collaboration Agreement shall apply.
  

	3 Forecasts and Orders	 	
3.1        Generally. On or before the first day of each month (the “Forecast Date”)
during the term of this TDA, commencing as of the date specified in Section 3.2 or 3.3 of this TDA as applicable, Tibotec shall submit to Gilead, a forecast of the quantity of Major Market Combination Product and Branded Region B/C Combination
Product that Tibotec expects to order [*] following the applicable Forecast Date (each, a “Forecast”). Each forecast shall be prepared in good faith consultation with Gilead. In addition, Tibotec shall, prior to the end of each
Calendar Year during the Term, provide Gilead with Tibotec’s good faith estimate of its annual requirements for Major Market Combination Product and Branded Region B/C Combination Product for [*] following the Calendar Year in which such
estimate is given; provided, however, that, in the case of [*]
  

3.2        Major Market Combination Product. Commencing [*] before the anticipated Launch in the
first (1st) Tibotec Country where Tibotec will be selling the Major Market Combination Product, Tibotec shall submit to Gilead a Forecast of the quantity of Major Market Combination Product that Tibotec expects to order for [*] following the
applicable Forecast Date. The quantity of the Major Market Combination Product set forth in a given Forecast for [*] shall be binding. Except as provided in the foregoing sentence, Forecasts shall be considered non-binding.

 
 3.3        Branded Region B/C Combination
Product. Commencing [*] before the anticipated Launch in the first Tibotec Country where Tibotec will be selling the Branded Region B/C Combination Product, Tibotec shall submit to Gilead a Forecast of the quantity of Branded Region B/C
Combination Product that Tibotec expects to order for [*] following the applicable Forecast Date. Branded Region B/C Combination Product set forth in a given Forecast for [*] shall be binding. Except as provided in the foregoing
sentence, Forecasts shall be considered non-binding.
  

  
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 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 Execution Version 

 

			
	 	  	
3.4        Orders and Non-Binding Period.

 
  3.4.1    Firm Orders. Tibotec
shall notify Gilead, in the form of a purchase order or other form agreed by the Parties (each a “Firm Order”), of the Units of each of Major Market Combination Product and Branded Region B/C Combination Product to be Delivered to
satisfy Tibotec’s requirements at least [*] prior to the date on which such Territory Combination Product is to be Delivered. Each Firm Order shall (a) be consistent with the quantity set forth in the applicable binding portion of the
Forecast; (b) be denominated in Units, unless otherwise mutually agreed by the Parties and (c) specify the Delivery date and any reasonable delivery instructions set forth in the Firm Order. Each Firm Order for Branded Region B/C Combination Product
shall be [*] and, provided, further, that Tibotec acknowledges and agrees that production yield rates for Branded Region B/C Combination Product may inherently vary and that as a result Delivered lot sizes may inherently vary from the
estimated lot size and the Parties’ obligations as to such inherent variation are detailed in Section 6.1.2 of this TDA.
  

 3.4.2    Non-Binding Forecasts [*] and by Supply Committee Determination. Notwithstanding Section
3.4.1, any Forecasts provided by Tibotec for [*] shall be deemed non-binding and the quantities of such Combination Product to be Delivered to Tibotec and timing of any such deliveries shall be determined by the Supply Committee and such
determination of quantities and timing by the Supply Committee shall be binding on both Parties.
  
 3.5        Russia. Tibotec shall place separate forecasts and Firm Orders for Major Market Combination Product that will be Distributed in Russia in
accordance with Section 3.2 and 3.4.
  

3.6        Japan. Tibotec shall place separate forecasts and Firm Orders for Major Market Combination
Product that will be Distributed in Japan in accordance with Section 3.2 and 3.4; provided, however, that such forecasts shall be [*]
  

3.7        Acceptance of Firm Orders. Within [*] of initial receipt of a Firm Order from Tibotec,
Gilead shall notify Tibotec whether it accepts or rejects such Firm Order. Gilead shall accept any such Firm Order from Tibotec to the extent that such Firm Order complies with the requirements above.

 
 3.8        Supply Committee. The
roles and responsibilities of the Supply Committee shall include the supply of Major Market Combination Product and Branded Region B/C Combination Product, including issues

  
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 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 Execution Version 

 

			
	 	  	 related to
supply for Japan and Russia and those responsibilities that are set forth in Section 2.2(c) of the TMC278 Supply Agreement but as applied to the Territory Combination Product rather than TMC278.

 
 3.9        Distribution Limitation.
Tibotec shall not Distribute (a) in Russia or Japan any Territory Combination Product ordered and Delivered for a country other than Russia or Japan, respectively, or (b) outside of Russia or Japan any Territory Combination Product ordered and
Delivered for Russia or Japan, respectively.
  

	4        Deviations
from Firm Orders	  	
4.1        [*] notify Tibotec of the quantities of Major Market Combination Product or Branded Region B/C
Combination Product, as applicable, that Gilead expects to be able to Deliver by the delivery date specified in the applicable Firm Order.
  

4.2        Reduced Order Quantity. In the event that Tibotec places a Firm Order that is less than the
binding Forecast for such period, [*]

	5        
Non-
Conforming Product	  	
5.1        Notice of Nonconformity. Tibotec shall notify Gilead in writing of any claim that any Territory
Combination Product supplied under this TDA is not in conformance with the warranties set forth herein (“Nonconforming”) [*] Tibotec shall promptly provide Gilead with a sample of such Nonconforming Territory Combination
Product, if available, and all relevant reports, data, and laboratory test results indicating that such Territory Combination Product is Nonconforming. Tibotec shall [*] If Gilead and Tibotec disagree as to whether Units of Territory
Combination Product are Nonconforming, Gilead and Tibotec shall designate an independent testing laboratory reasonably acceptable to both Parties to make a determination, which determination shall be binding on the Parties, absent manifest error.
Gilead shall [*]
  

5.2        [*] Nonconforming Territory Combination Product. If the independent testing laboratory (as set
forth above) determines that the Territory Combination Product was Nonconforming or the Parties agree that the Territory Combination Product was Nonconforming, then [*]

 
 5.3        Destruction of Nonconforming
Territory Combination Product. Tibotec shall arrange for the destruction, return or other disposal, at Gilead’s election, of any Nonconforming Territory Combination Product in compliance with Gilead’s instructions and Applicable Law.
[*]
  

	6 Territory Combination Product Shortage;	  	
6.1        Inadequate Delivered Quantity of Territory Combination
Product.

  
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 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

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	Failure to Supply	 	     6.1.1    Tibotec shall notify Gilead in writing of any failure to Deliver Major Market Combination Product or a shortage in quantity in any shipment of Major
Market Combination Product (as compared with the amount specified for Delivery in the applicable Firm Order given by Tibotec (as set forth above)) [*] days after Delivery (or scheduled Delivery) thereof. In the event Gilead disagrees with any claim
of shortage by Tibotec, each Party shall designate a representative to be present at the inventorying of the at-issue Major Market Combination Product, the results of which shall be binding on the Parties, absent manifest error (and Gilead shall
invoice Tibotec solely based on such binding inventory). Gilead shall use its Commercially Reasonable Efforts to promptly Deliver any shortage amount (as agreed upon by the Parties or determined by the inventory) of Major Market Combination Product
as promptly as possible. [*]
  

    6.1.2    For Firm Orders of Branded Region B/C Combination Product, Gilead’s
obligation to Deliver shall be deemed fulfilled if Gilead delivers [*]
  
 6.2        Shortage of Territory Combination Product. If Gilead is unable to supply the full quantities of Territory Combination Product set forth in the
Firm Orders from Tibotec and its Affiliates together with the amounts of Territory Combination Product needed by Gilead and its Affiliates, then Gilead shall allocate the available supply of Territory Combination Product [*]

 
 6.3        Notification and Cure. If
Gilead fails to supply Territory Combination Product for which it has received a Firm Order in accordance with this TDA, [*] then the matter shall be referred to the Executives for resolution pursuant to Section 2.4 of the Collaboration Agreement;
provided that subsection 2.4(b) thereof shall not apply to such resolution.
  

6.4        Other Remedies. Subject to the express limitations set forth herein, the remedies set forth in
this Section 6 for a material breach by Gilead shall be in addition to any other remedies Tibotec may have under this TDA, the Collaboration Agreement, or at law.

	7        Territory
Combination Product Packaging by Gilead	 	
7.1        Labeling. Gilead shall supply Tibotec with Units of unlabeled bottles of Territory Combination
Product.
  

7.2        Packaging. Each shipment shall be packed, sealed, and shipped in accordance with Gilead’s
customary packaging practices and GMP.
  

	8        
Packaging,	 	8.1 Gilead shall assist Tibotec in establishing proper
procedures with

  
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IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

			
	Labeling and Storage Technology Transfer; Packaging and
Labeling Requirements	 	 respect to
packaging, labeling and storage of Territory Combination Product.
  

8.2        Gilead shall provide Tibotec with the core secondary packaging and packaging insert artwork with
respect to the Territory Combination Product (“Core Materials” ) for use by Tibotec in packaging and labeling Territory Combination Product. Tibotec shall use the Core Materials to package and label the Territory Combination
Product, but shall modify the Core Materials as required by Applicable Law and shall provide any necessary translations. Gilead shall have the right, but not the obligation, to review and approve in advance the Core Materials, as so modified, for
any country for which Tibotec is the Selling Party.
  

	9        Territory
Combination Product Delivery	 	
9.1        Delivery shall be [*]

 
 9.2        The shipment shall be labeled
with a traceable batch number. The bill of lading shall list the gross weight and net weight of the shipment. Concurrent with each shipment of Territory Combination Product, Gilead shall provide Tibotec with an electronic copy of the certificate of
analysis confirming that such batch meets the applicable Specifications. In addition, upon delivery to Tibotec’s carrier, Gilead shall provide Tibotec with notice that the shipment has been delivered, including the quantity of Territory
Combination Product delivered. If Tibotec requests, Gilead shall provide a written certificate of compliance for a batch or batches of Territory Combination Product delivered to Tibotec.

 

	
10        Safety Stock

 
	 	10.1        
Safety Stocks. [*] 
	11        Quality
Control	 	
11.1        Warranty on Territory Combination Product. Gilead represents and warrants that, at the time of
Delivery, the Territory Combination Product supplied hereunder, other than as a result of any defect or condition of the Supplied TMC278 included therein, including any breach of any warranty with respect to the Supplied TMC278 made by Tibotec in
the TMC278 Supply Agreement (a) shall have been Manufactured in accordance with GMP and Applicable Law, and (b) shall conform to the Territory Combination Product Specifications for Major Market Combination Product or Branded Region B/C Combination
Product, as applicable, and the applicable certificate of analysis.
  

11.2        Changes to Territory Combination Product Specifications.

 
       11.2.1 Changes to Territory
Combination Product Specifications that are an Additional Requirement, shall be governed by Section 8.4 of the Collaboration Agreement. All other changes to the Territory Combination Product Specifications for Major Market
Combination

  
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 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 Execution Version 

 

			
	 	 	 Product or
Branded Region B/C Combination Product shall be subject to the provisions in this TDA.
  
 11.2.2 If Gilead wishes to amend the Territory Combination Product Specifications, Gilead shall provide written notice thereof to the Tibotec. [*] Prior to delivery of Territory Combination Product
to Tibotec pursuant to this TDA and solely to the extent not provided in the Product Specifications, Gilead shall establish and provide to Tibotec the specifications for bottle size and shape with respect to the supplied Territory Combination
Product. Any changes to such bottle size and shape specifications shall be treated in accordance with the process for changing the Product Specifications.
  

11.3        Territory Combination Product Manufacturing-Related Changes. Manufacturing-related changes that
are an Additional Requirement shall be governed by Section 8.4 of the Collaboration Agreement. Subject to the requirements above, other manufacturing-related changes with respect to Territory Combination Product, [*] Any Manufacturing-Related
Changes made with respect to Territory Combination Product shall, in each case, comply with GMP and Applicable Law. In the event of any such change, Gilead shall (i) be responsible to ensure that all Territory Combination Product Manufactured under
the changed Manufacturing process by or on behalf of Gilead or its Affiliates meets the applicable Territory Combination Product Specifications, and (ii) provide Tibotec in a timely manner with all information reasonably needed to make corresponding
amendments to the applicable regulatory filings in the Territory maintained by Tibotec with respect to the Territory Combination Product (including amending Approvals in the Territory), to the extent necessary.

 
 11.4        Quality
Agreements.
  
   11.4.1 Between Gilead
and its CMOs. During the term of this TDA, Gilead shall have quality agreements in place with each of its Contract Manufacturers that Manufacture Territory Combination Product for supply hereunder. Such quality agreements shall, at a minimum,
have terms governing GMP compliance as are customary in the pharmaceutical industry.
  
   11.4.2 Between Gilead and Tibotec. Prior to the shipment of any Territory Combination Product hereunder, the Parties shall enter into an agreement which sets out the policies,
procedures, and standards by which the Parties shall coordinate and implement the operational and quality assurance activities and regulatory compliance objectives contemplated under this TDA with respect to the Territory
Combination

  
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AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

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	 	 	 Product and
the subsequent labeling, packaging and storage of such Territory Combination Product by Tibotec (the “Quality Agreement”). Any amendment to the Quality Agreement shall require the written agreement of the Parties.

 
 11.4.3 Between Tibotec and its CMOs. During the term of
this TDA, Tibotec shall have quality agreements in place with each of its CMOs that package, label or handle Territory Combination Product purchased hereunder. Such quality agreements shall, at a minimum, have terms governing GMP compliance as are
customary in the pharmaceutical industry.
  

	12        
Combination Product Inspections	 	
12.1        [*] Inspections. During the term of this TDA and no more than [*] (a) Tibotec and/or its agents
may inspect, during regular business hours, [*] to ascertain compliance with GMP, Applicable Law, the Territory Combination Product Specifications and the terms of this TDA in the Manufacture, handling and shipping of Territory Combination Product;
and (b) Gilead and/or its agents may inspect, during regular business hours, [*] to ascertain compliance with GMP, Applicable Law, the Territory Combination Product Specifications and the terms of this TDA.

 
 Any such inspection of a Contract Manufacturer, a Gilead Manufacturer or a Tibotec
Packager shall be coordinated with inspections thereof conducted by or on behalf of the other Party or its Affiliates, and may be conditioned on the execution of a customary confidentiality agreement between the inspecting Party (or its agent) and
such Contract Manufacturer, Gilead Manufacturer or Tibotec Packager. As part of any inspection conducted pursuant to this Section, the inspecting Party and/or its agents may inspect, as applicable, [*] (such activities, an
“Inspection”).
  

12.2        “For Cause” Inspection.

 
 12.2.1 Tibotec may conduct an Inspection of the relevant
facilities of any Gilead Manufacturer that supplies Territory Combination Product hereunder, if such an Inspection is a reasonable response to a Regulatory Authority audit notice or inquiry regarding any Territory Combination Product, an unresolved
deviation in the Manufacture of the Territory Combination Product, or customer complaints or adverse events regarding the Territory Combination Product. Tibotec and Gilead shall coordinate in good faith as to the timing of any Inspection of a
Contract Manufacturer conducted pursuant to this Section and Gilead or its designee shall be present at any such Inspection.

 

  
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ACT OF 1934, AS AMENDED 

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	 	 	 12.2.2 Gilead may conduct an Inspection of the relevant facilities of any Tibotec Packager, if such an Inspection is a reasonable response to a Regulatory Authority audit notice or inquiry regarding any
Territory Combination Product, an unresolved deviation in the packaging, labeling or storage of the Territory Combination Product, or customer complaints or adverse events regarding the Territory Combination Product. Tibotec and Gilead shall
coordinate in good faith as to the timing of any Inspection of a Contract Manufacturer conducted pursuant to this Section and Tibotec or its designee shall be present at any such Inspection.

 
 12.3      Remedial Efforts. Following any
Inspection conducted (as described above), the Parties shall meet to discuss the inspecting Party’s findings, and [*]
  

	13    Payments	 	
13.1      Territory Combination Product. Subject to the terms and conditions of this TDA and the Collaboration
Agreement, for Territory Combination Product Delivered by Gilead to Tibotec hereunder, Gilead shall issue to Tibotec an invoice upon shipment of the Territory Combination Product as provided in Annex BB of the Collaboration Agreement. Each such
invoice shall state the quantity of Major Market Combination Product and Branded Region B/C Combination Product covered by such invoice and specify all amounts due in United States Dollars. Subject to the terms and conditions of this TDA and the
Collaboration Agreement, Tibotec shall pay each such invoice in accordance with the payment terms set forth in Annex BB of the Collaboration Agreement.
  

13.2      Expenses. Any expenses and/or losses hereunder which are deemed in this TDA to be included in the
Manufacturing Fee shall be calculated and invoiced in accordance with Section 10.2 of the Collaboration Agreement. Unless otherwise agreed by the Parties (including in the preceding sentence and in Section 10 of the Collaboration Agreement), (a)
each Party promptly shall invoice the other Party for any amounts due under this TDA and (b) each Party shall pay any valid invoice provided by the other Party pursuant to this TDA within [*] after receipt of such invoice.

 

	14    Tibotec Representations,
Warranties and Covenants	 	
14.1      Warranty on Distributed Territory Combination Product. Tibotec represents and warrants that, at the time of
distribution or sale of Territory Combination Product supplied hereunder to Third Parties, that such Territory Combination Product shall not be expired or otherwise unfit for sale as a result of Tibotec’s packaging, labeling, handling or
storage of such Territory Combination Product and such Territory Combination Product shall be in conformance with the Territory Combination Product Specifications and Applicable Law with respect to packaging and labeling.

 

  
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ACT OF 1934, AS AMENDED 

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14.2      Permits. Tibotec shall obtain and maintain, all necessary permits for the packaging, labeling, receipt,
storage, handling and distribution of Territory Combination Product at the facility(ies) where Territory Combination Product supplied hereunder is packaged, labeled and/or stored by or on behalf of Tibotec or its Affiliates.

 
 14.3      Manufacturing and Storage Records.
Tibotec shall maintain complete and accurate records relating to the receipt, handling, storage, use, packaging, labeling and disposal by or on behalf of Tibotec or its Affiliates of the Territory Combination Product supplied hereunder and standard
operating procedures for the foregoing in accordance with Applicable Law and GMP and shall provide a written account of any discrepancies. Gilead shall have the right to review such records upon the reasonable request of Gilead.

 
 14.4      Packaging and Labeling
Specifications. Tibotec shall label and package the Territory Combination Product in accordance with GMP and Applicable Law for the country or region in which such Territory Combination Product will be sold, released or distributed. If any
Territory Combination Product intended for release, sale or distribution by Tibotec fails to comply with the labeling and packaging requirements in accordance with the Territory Combination Product Specifications or Applicable Law for the country or
region in which such Territory Combination Product will be sold, released or distributed, then Tibotec shall not release, sell or distribute such Territory Combination Product.

 
 14.5      Tibotec Packagers. Tibotec shall, or
shall cause the Tibotec Packagers to, maintain the facilities, equipment and machinery used in connection with the labeling and packaging of Territory Combination Product in a state of repair and operating efficiency that enables it to meet the
applicable Territory Combination Product Specifications. Tibotec shall, or shall cause such Tibotec Packagers to, validate the equipment and the labeling and packaging process and any other appropriate steps performed at such facilities and
validate/calibrate all instruments used in testing such equipment and machinery, in each case to the extent used in connection with the labeling or packaging of Territory Combination Product and as required by GMP and Applicable Law.

 
 14.6      Handling and Storage. Tibotec shall
at all times handle, store and transport Territory Combination Product in accordance with Applicable Law, GMP and GDP and in a manner and with a level of care consistent with Tibotec’s handling, storage and transport of similar pharmaceutical
products.
  

  
 10 

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 Execution Version 

 

			
	15 Consequences of Termination	 	
15.1      Consequences of Termination. In the event the Collaboration Agreement terminates or upon Tibotec ceasing to
Distribute Territory Collaboration Product and/or there ceasing to be any Tibotec Countries, the following provisions shall apply:
  

15.1.1 Prior Orders. [*]
  

15.1.2 Territory Combination Product. Upon termination of the Collaboration Agreement by Tibotec for a Material Breach by
Gilead, [*]
  

	16 Survival	 	 The following provisions of this TDA shall
survive the expiry or termination of the Collaboration Agreement (which expiration or termination shall automatically terminate this TDA): Sections 1, 3.9, 9 (with respect to any Territory Combination Product Delivered following termination of this
TDA), 11.1, 11.4.3, 14.3 (to the extent such records are required for a period of three (3) years following termination), 15, 16, 17 and 18. In addition to any other Sections which may survive pursuant to this Section 16, the provisions of Sections
2.2, 3.8, 5 (provided that there shall be no obligation to replace Nonconforming Territory Combination Product), 6 (provided that there shall be no obligation to [*]), 8.2 (solely with respect to Tibotec’s packaging and labeling
obligations), 13 and 14 shall survive, in each case solely with regard to the Territory Combination Product Delivered by Gilead.
  

	17 Subcontracting	 	 Subject to the terms and conditions of this TDA,
Gilead may subcontract the Manufacture of Territory Combination Product to one or more Contract Manufacturers. Gilead shall have the right to select such Contract Manufacturers in its sole discretion. In the event that Gilead delegates any of its
obligations under this TDA to a subcontractor, Gilead shall remain primarily (and not secondarily or derivatively) liable for the full and timely performance by such subcontractor of all its obligations under this TDA. Notwithstanding anything to
the contrary contained herein, if Gilead engages a subcontractor to fulfill any of Gilead’s obligations hereunder, Gilead shall cause such subcontractor to comply with the provisions of this TDA.

 

	18 Incorporation with Collaboration Agreement;
Interpretation	 	This TDA is incorporated into and subject to the terms of
the Collaboration Agreement. If there is any inconsistency between the provisions of this TDA and the provisions of the Collaboration Agreement, the provisions of the Collaboration Agreement shall control. If there is any inconsistency between the
provisions of this TDA and the Quality Agreement, or any purchase order, confirmation, or other document passing between the Parties relating to supply of Territory

  
 11 

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED 

 Execution Version 

 

			
	 	 	 Combination
Product by Gilead to Tibotec or the subsequent packaging, handling or storage of the Territory Combination Product by Tibotec hereunder, the provisions of this TDA shall control except that the Quality Agreement controls with respect to procedures
for verifying compliance with quality requirements.
  

  
 12 

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED
IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDEDNote Modification Agreement dated August 19, 2011

 Exhibit 10.1 
 Note Modification Agreement 
 CHASE 

This agreement is dated as of August 19, 2011, (the “Agreement Date”), by and between Syntel, Inc. (the “Borrower”) and JPMorgan
Chase Bank, N.A. (together with its successors and assigns, the “Bank”). The provisions of this agreement are effective on the date that this agreement has been executed by all of the signers and delivered to the Bank (the “Effective
Date”). 
 WHEREAS, the Borrower executed a Line of Credit Note dated as of August 3, 2009 in the original principal amount of
Twenty Million and 00/100 Dollars ($20,000,000.00), (as same may have been amended or modified from time to time, the “Note”) as evidence of an extension of credit from the Bank to the Borrower, which Note has at all times been, and is
now, continuously and without interruption outstanding in favor of the Bank; and, 
 WHEREAS, the Borrower has requested and the Bank has
agreed that the Note be modified to the limited extent as hereinafter set forth in this agreement; 
 NOW THEREFORE, in mutual
consideration of the agreements contained herein and for other good and valuable consideration, the parties agree as follows: 
  

	1.	ACCURACY OF RECITALS. The Borrower acknowledges the accuracy of the Recitals stated above. 

2. DEFINITIONS. Capitalized terms used in this agreement shall have the same meanings as in the Note, unless otherwise defined in this agreement.

  

	3.	MODIFICATION OF NOTE: 

3.1 From and after the Effective Date, the provision in the Note captioned “Promise to Pay” is hereby amended as follows: The
date on which the entire balance of unpaid principal plus accrued interest shall be due and payable immediately is hereby changed from August 31, 2011 to August 31, 2012. 

3.2 Principal Payments. All outstanding principal and interest is due and payable in full on August 31, 2012, which is
defined herein as the “Principal Payment Date”. 
 3.3 Each of the Related Documents is modified to provide that it
shall be a default or an event of default thereunder if the Borrower shall fail to comply with any of the covenants of the Borrower herein or if any representation or warranty by the Borrower herein or by any guarantor in any Related Documents is
materially incomplete, incorrect, or misleading as of the date hereof. As used in this agreement, the “Related Documents” shall include the Note and all applications for letters of credit, loan agreements, credit agreements, reimbursement
agreements, security agreements, mortgages, deeds of trust, pledge agreements, assignments, guaranties, or any other instrument or document executed in connection with the Note or in connection with any other obligations of the Borrower to the Bank.

 3.4 Each reference in the Related Documents to any of the Related Documents shall be a reference to such document as modified
by this agreement. 
 4. RATIFICATION OF RELATED DOCUMENTS AND COLLATERAL. The Related Documents are ratified and reaffirmed by the
Borrower and shall remain in full force and effect as they may be modified by this agreement. All property described as security in the Related Documents shall remain as security for the Note, as modified by this agreement, and the Liabilities under
the other Related Documents. 
 5. BORROWER REPRESENTATIONS AND WARRANTIES. The Borrower represents and warrants to the Bank that each of
the representations and warranties made in the Note and the other Related Documents and each of the following representations and warranties are and will remain, true and correct until the later of maturity or the date on which all Liabilities
evidenced by the Note are paid in full: 
 5.1 No default, event of default or event that would constitute a default or event of
default but for the giving of notice, the lapse of time or both, has occurred and is continuing under any provision of the Note, as modified by this agreement, or any other Related Document. 

5.2 No event has occurred which may in any one case or in the aggregate materially and adversely affect the financial condition,
properties, business, affairs, prospects or operations of the Borrower or any guarantor or any subsidiary of the Borrower. 

  
 38 

 5.3 The Borrower has no defenses or counterclaims, offsets or adverse claims, demands or
actions of any kind, personal or otherwise, that it could assert with respect to the Note or any other Liabilities. 
 5.4 The
Note, as modified by this agreement, and the other Related Documents are the legal, valid, and binding obligations of the Borrower and the other parties, enforceable against the Borrower and other parties in accordance with their terms, except as
may be limited by bankruptcy, insolvency or other laws affecting the enforcement of creditors’ rights generally and by general principles of equity. 
 5.5 The Borrower, other than any Borrower who is a natural person, is validly existing under the laws of the State of its formation or organization. The Borrower has the requisite power and authority to
execute and deliver this agreement and to perform the obligations described in the Related Documents as modified herein. The execution and delivery of this agreement and the performance of the obligations described in the Related Documents as
modified herein have been duly authorized by all requisite action by or on behalf of the Borrower. This agreement has been duly executed and delivered by or on behalf of the Borrower. 

 

	6.	BORROWER CONVENANTS. The Borrower covenants with the Bank: 

 6.1 The Borrower shall execute, deliver, and provide to the Bank such additional agreements, documents, and instruments as reasonably required by the Bank to effectuate the intent of this agreement.

 6.2 The Borrower fully, finally, and forever releases and discharges the Bank, its successors, and assigns and their
respective directors, officers, employees, agents, and representatives (each a “Bank Party”) from any and all causes of action, claims, debts, demands, and liabilities, of whatever kind or nature, in law or equity, of the Borrower, whether
now known or unknown to the Borrower, (i) in respect of the loan evidenced by the Note and the Related Documents, or of the actions or omissions of any Bank Party in any manner related to the loan evidenced by the Note or the Related Documents
and (ii) arising from events occurring prior to the date of this agreement. 
 6.3 To the extent not prohibited by
applicable law, the Borrower shall pay to the Bank: 
 6.3.1 All the internal and external costs and expenses incurred (or
charged by internal allocation) by the Bank in connection with this agreement (including, without limitation, inside and outside attorneys, appraisal, appraisal review, processing, title, filing, and recording costs, expenses and fees). 

7. EXECUTION AND DELIVERY OF AGREEMENT BY THE BANK. The Bank shall not be bound by this agreement until (i) the Bank has executed this
agreement and (ii) the Borrower performed all of the obligations of the Borrower under this agreement to be performed contemporaneously with the execution and delivery of this agreement. 
 8. INTEGRATION, ENTIRE AGREEMENT, CHANGE, DISCHARGE, TERMINATION, OR WAIVER. The Note, as modified by this agreement, and the other Related Documents contain the complete understanding and
agreement of the Borrower and the Bank in respect of any Liabilities evidenced by the Note and supersede all prior understandings, and negotiations. If any one or more of the obligations of the Borrower under this agreement or the Note, as modified
by this Agreement, is invalid, illegal or unenforceable in any jurisdiction, the validity, legality and enforceability of the remaining obligations of the Borrower shall not in any way be affected or impaired, and the invalidity, illegality or
unenforceability in one jurisdiction shall not affect the validity, legality or enforceability of the obligations of the Borrower under this agreement, the Note as modified by this agreement and the other Related Documents in any other jurisdiction.
No provision of the Note, as modified by this agreement, or any other Related Documents may be changed, discharged, supplemented, terminated, or waived except in a writing signed by the party against whom it is being enforced. 

9. GOVERNING LAW AND VENUE. This agreement shall be governed by and construed in accordance with the laws of the State of Michigan (without giving
effect to its laws of conflicts). The Borrower agrees that any legal action or proceeding with respect to any of its obligations under the Note or this agreement may be brought by the Bank in any state or federal court located in the State of
Michigan, as the Bank in its sole discretion may elect. By the execution and delivery of this agreement, the Borrower submits to and accepts, for itself and in respect of its property, generally and unconditionally, the non-exclusive jurisdiction of
those courts. The Borrower waives any claim that the State of Michigan is not a convenient forum or the proper venue for any such suit, action or proceeding. This agreement binds the Borrower and its successors, and benefits the Bank, its successors
and assigns. The Borrower shall not, however, have the right to assign the Borrower’s rights under this agreement or any interest therein, without the prior written consent of the Bank. 
 10. COUNTERPART EXECUTION. This agreement may be executed in multiple counterparts, each of which, when so executed, shall be deemed an original, but all such counterparts, taken together, shall
constitute one and the same agreement. 

  
 39 

 11. NOT A NOVATION. This agreement is a modification only and not a novation. In addition to all
amounts hereafter due under the Note, as modified by this agreement, and the other Related Documents, all accrued interest evidenced by the Note being modified by this agreement and all accrued amounts due and payable under the Related Documents
shall continue to be due and payable until paid. Except for the modification(s) set forth in this agreement, the Note, the other Related Documents and all the terms and conditions thereof, shall be and remain in full force and effect with the
changes herein deemed to be incorporated therein. This agreement is to be considered attached to the Note and made a part thereof. This agreement shall not release or affect the liability of any guarantor, surety or endorser of the Note or release
any owner of collateral securing the Note. The validity, priority and enforceability of the Note shall not be impaired hereby. References to the Related Documents and to other agreements shall not affect or impair the absolute and unconditional
obligation of the Borrower to pay the principal and interest on the Note when due. The Bank reserves all rights against all parties to the Note and the other Related Documents. 
 12. TIME IS OF THE ESSENCE. Time is of the essence under this agreement and in the performance of every term, covenant and obligation contained herein. 

Borrower: 
  

							
	 Address: 525 East Big Beaver Road
                  Troy, MI 48083
	 	Syntel, Inc.
				
		 		 	By:	 	                /s/ Prashant Ranade
		 		 		 	Prashant Ranade – CEO & President
		 		 		 	Printed
Name                                Title
			
		 		 	Date Signed:                         
                                         
                                    
				
		 		 	By:	 	                /s/ Arvind Godbole
		 		 		 	                Arvind Godbole – CFO & CISO
		 		 		 	Printed
Name                                 Title
			
		 		 	Date Signed: Sept. 5, 2011
			
	BANK’S ACCEPTANCE	 		 	
			
	The foregoing agreement is hereby agreed to and acknowledged.	 		 	
			
		 		 	Bank:
			
		 		 	JPMorgan Chase Bank, N.A.
				
		 		 	By:	 	                /s/ Jeffrey Matthew Jodzis
		 		 		 	JEFFREY MATTHEW JODZIS V.P.
		 		 		 	Printed
Name                                 Title
			
		 		 	Date Signed: 09-21-11

  
 40

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