Document:

First Amendment dated March 9, 2007, to Lease Agreement, dated July 1, 2001

 Exhibit 10.253 
 Tenant: PPD Development, LLC 
 Suite: Dabney VII, Addition of Suites L, M & N 
 FIRST AMENDMENT TO LEASE 
 THIS FIRST AMENDMENT TO LEASE (this “Amendment) is made and entered into as of
March 9, 2007, by and between BRANDYWINE GRANDE C, L.P., a Delaware limited partnership (“Landlord”), and PFD DEVELOPMENT, LP, a Texas limited partnership (“
Tenant”). 
 A. Landlord and Tenant, as successor-in-interest to PPD Development, LLC, are parties to a certain
Lease (the “Lease”) dated as of July 1,2001, for approximately 75,133 rentable square feet of space (the “Original Premises”), as more particularly described in the Lease.

 B. Tenant desires to lease from Landlord, and Landlord desires to lease to Tenant, certain additional premises known as
Suites L, M and N (the “Suites L, M & N Premises”) in the Dabney VII building located at 2246 Dabney Road, Richmond, Virginia 23230 (the “Dabney VII Building”), which additional premises are shown on the
location plan attached hereto as Exhibit A. The parties hereby confirm that the Suites L, M & N Premises are 6,577 rentable square feet of space in the aggregate. 
 C. The portion of the Suites L, M & N Premises comprising Suites M & N contains 4,580 rentable square feet and is referred to herein as
“Suites M & N”. The portion of the Suites L, M & N Premises comprising Suite L contains 1,997 rentable square feet and is referred to heroin as “Suite L”. 
 D. Landlord and Tenant wish to amend the Lease to, among other things, expand the Original Premises to include the Suites L, M & N Premises upon the
terms and conditions set forth herein, 
 NOW, THEREFORE, in consideration of the mutual covenants and agreements contained herein, Landlord
and Tenant hereby agree as follows: 
 1. Incorporation of Recita ls: Definitions. The recitals set forth above are hereby incorporated
herein by reference as if set forth in full in the body of this Amendment Capitalized terms used but not otherwise defined in this Amendment shall have the respective meanings given to them in the Lease. 
 2. Premises. 
 (a) Effective on the
Suites M & N Commencement Date (as defined in Section 3(a) below), as used in the Lease: (i) “Premises” shall mean, collectively, the Original Premises and Suites M & N; (ii) “Tenant’s
Allocated Share” with respect to the Dabney VII Building shall mean 94.0%; and (ii) “Rentable Area” with respect to the Premises shall mean 79,713. 
 (b) Effective on the Suite L Commencement Date (as defined in Section 3(b) below), as used in the Lease; (i) “Premises”
shall mean, collectively, the Original Premises and Suite L; (ii) “Tenant’s Allocated Share” with respect to the Dabney VII Building shall mean 86.23% and (ii) “Rentable Area” with respect to the
Premises shall mean 77,130. 
 (e) Notwithstanding the foregoing, effective on the later of the Suites M & N Commencement Date and the
Suite L Commencement Date, as used in the Lease: (i) “Premises” shall mean, collectively, the Original Premises, Suite L, and Suites M & N; (ii) “Tenant’s Allocated Share” with respect to the
Dabney VII Building shall mean 100%; and (iii) “Rentable Area” with respect to the Premises shall mean 81,710 square feet. 
 (d) Tenant acknowledges and agrees that, notwithstanding any provision of the Lease to the contrary, Landlord shall have no obligation to make any improvements to the Suites L, M & N Premises in connection with this amendment, and
Tenant accepts them in their current “AS IS” condition. 

 3. Term. 
 (a) The Term for Suites M & N shall commence on the date Landlord delivers possession of the Suites M & N to Tenant (the “Suites M & N Commencement Date”); provided if Landlord is unable
to deliver possession of Suites M & N to Tenant on any particular date for any reason, including without limitation the holdover of the current tenant, the Lease as amended hereby shall continue in effect and Landlord shall not be liable to
Tenant or any third party for such inability. The Suites M & N Commencement Date and expiration date of the Term shall be confirmed by Landlord and Tenant by the execution of a Confirmation of Lease Term (the “COLT”) in the form
attached hereto as Exhibit B. If Tenant fails to execute or object to the COLT within ten (10) business days of its delivery, Landlord’s determination of such dates shall be deemed accepted. 
 (b) The Term for Suite L shall commence on the date Landlord delivers possession of Suite L to Tenant (the “Suite L Commencement Date”),
which data is estimated to be May 1, 2007; provided if Landlord is unable to deliver possession of Suite L to Tenant on any particular date for any reason, including without limitation the holdover of the current tenant, the Lease as amended
hereby shall continue in effect and Landlord shall not be liable to Tenant or any third party for such inability. The Suite L Commencement Date and expiration date of the Term shall be confirmed by Landlord and Tenant by the execution of a
Confirmation of Lease Term (the “COLT”‘) in the form attached hereto as Exhibit B. If Tenant fails to execute or object to the COLT within ten (10) business days of its delivery, Landlord’s determination of such dates
shall be deemed accepted. 
 (c) The Term for the Premises (collectively, the Original Premises and the Suites L, M & N Premises) shall
terminate on June 30, 2015. 
 4. Fixed Rent. Fixed Rent for Suites M & N is set forth below, payable in the monthly
installments as set forth below and otherwise in accordance with the terms of the Lease, as amended hereby: 
  

				
	 TIME PERIOD
	 	MONTHLY INSTALLMENTS
	 Suites M & N Commencement Date -
 3/31/07
	 	$	0.00
	 4/1/07 - 6/30/08
	 	$	2,480.83
	 7/1/08 - 6i30/09
	 	$	2,541.90
	 7/1/09 - 6/30/10
	 	$	2,606.78
	 7/1/10 - 6/30/11
	 	$	2,671.67
	 7/1/11 - 6/30/12
	 	$	2,740.37
	 7/1/12 - 6/30/13
	 	$	2,809.07
	 7/1/13 - 6/30/14
	 	$	2,877.77
	 7/1/14 - 6/30/15
	 	$	2,950.28

 Fixed Rent for Suite L is set forth below, payable in the monthly installments as set forth below and otherwise in
accordance with the terms of the Lease, as amended hereby: 
  

				
	 TIME PERIOD
	 	MONTHLY INSTALLMENTS
	 Suite L Commencement Date -
 6/30/08
	 	$	1,081.71
	 7/1/08 - 6/30/09
	 	$	1,108.34
	 7/1/09 - 6/30/10
	 	$	1,136.63
	 7/1/10 - 6/30/11
	 	$	1,164.92
	 7/1/11 - 6/30/12
	 	$	1,194.87
	 7/1/12 - 6/30/13
	 	$	1,224.83
	 7/1/13 - 6/30/14
	 	$	1,254.78
	 7/1/14 - 6/30/15
	 	$	1,286.40

 Fixed Rent shall be payable by: (i) check to Landlord at Post Office Box 828117, Philadelphia, PA 19182-8117; or
(ii) wire transfer of immediately available funds to the account at PNC Bank, account no. 8610818762, with ABA routing number 031000053. 
 5. Landlord’s Notice Address. Landlord’s “Notice Address/Contact” set forth in Section 1(k) of the Lease is hereby deleted in its entirety and replaced with the following in lieu thereof: 

 

					
	Landlord:	  	Brandywine Grande C, L.P.	  	With a copy to:
		  	c/o Brandywine Realty Trust 300	  	Brandywine Realty Trust
		  	Arboretum Place, Suite 330	  	555 East Lancaster Ave-, Suite 100
		  	Richmond, VA 23236	  	Radnor, PA 19087
		  	Attn: William D. Redd	  	Attn: Brad A. Molotsky, General Counsel
		  	Fax No.: (804) 330-4450	  	Fax No,: (610) 325-4628
		  	E-Mail: bill.redd@bdnreit.com	  	Email: brad.molotsky@bdnreit.com

 Each party shall have the right to change its address for notices by a writing sent to the other party in
accordance with Article 28, of the Lease. 
 6, Brokerage Commission, Landlord and Tenant each represents and warrant~: to the
other that such party has had no dealings, negotiations or consultations with respect to the Premises or this transaction with any broker or finder other than BTRS, Inc. Each party shall indemnify and hold the other harmless from and against all
liability, cost and expense, including attorney’s fees and court costs, arising out of any misrepresentation or breach of warranty under this Section. 
 7. OFAC. Tenant represents, warrants and covenants that neither Tenant nor any of its
partners, officers, directors, members or shareholders: (i) is listed on the Specially Designated Nationals and Blocked Persons List maintained by the Office of Foreign Asset Control, Department of the Treasury (“OFAC”)
pursuant to Executive Order No. I3224, 66 Fed, Reg. 49079 (Sept. 25, 2001) (“Qrder”) and all applicable provisions of Title III of the USA Patriot Act (Public Law No. 107-56 (October 26, 2001)); (ii) is listed
on the Denied Persons List and Entity List maintained by the United States Department of Commerce; (iii) is listed on the List of Terrorists and List of Disbarred Parties maintained by the United States Department of State; (iv) is listed
on any list or qualification of “Designated Nationals” aw defined in the Cuban Assets Control Regulations 31 C.F.R. Part 515; (v) is listed on any other publicly available list of terrorists, terrorist
organizations or narcotics traffickers maintained by the United States Department of State, the United States Department of Commerce or any other governmental authority or pursuant to the Order, the rules and regulations of OFAC (including without
limitation the Trading with the Enemy Act, 50 U.S.C. App. 1-44; the International Emergency Economic Powers Act, 50 U.S.C. §§ 1701-06; the unrepealed provision of the Iraq Sanctions Act, Publ.L. No, 101-513; the United Nations
Participation Act, 22 U.S.C. § 2349 as-9; The Cuban Democracy Act, 22 U.S.C. §§ 6001-10; The Cuban Liberty and Democratic Solidarity Act, 18 U.S.C. §§ 2332d and 233; and The Foreign Narcotic Kingpin Designation Act, Publ. L.
No. 106-120 and 107-108, all as may be amended from time to time); or any other applicable requirements contained in any enabling legislation or other Executive Orders in respect of the Order (the Order and such other rules, regulations,
legislation or orders are collectively called the “Orders”); (vi) is engaged in activities prohibited in the Orders; or (vii) has been convicted, pleaded nolo contondere, indicted, arraigned or custodially detained on
changes involving money laundering 

 
or predicate crimes to money laundering, drug trafficking, terrorist-related activities or other money laundering predicate crimes in connection with the
Bank Secrecy Act (31 U.S.C. §§ 5311 et seq.). Tenant shall defend, indemnify, and hold harmless Landlord from and against any and all claims, damages, losses, risks, liabilities, and expenses (including 

 
attorney’s fees and costs) arising from or related to any breach of the foregoing representation, warranty and covenant. The breach of this
representation, warranty and covenant by Tenant shall be an immediate Event of Default under this Lease without cure. 
 8. Effect of
Amendment: Ratification. Landlord and Tenant hereby acknowledge and agree that, except as provided in this Amendment, the Lease has not been modified, amended, canceled, terminated, released, superseded or otherwise rendered of no force or
effect. The Lease as hereby amended is hereby ratified and confirmed by the parties hereto, and every provision, covenant, condition, obligation, right, term and power contained in and under the Lease, as amended herein, shall continue in full force
and effect, affected by this Amendment only to the extent of the amendments and modifications set forth above, and each shall continue to be binding upon and inure to the benefit of the heirs, executors, administrators, successors and assigns of
each party hereto. 
 9. Authority. Each of Landlord and Tenant represents and warrants to the other that the individual executing
this Amendment on such party’s behalf is authorized to do so. 
 [SIGNATURES ON FOLLOWING PAGE] 

 IN WITNESS WHEREOF, Landlord and Tenant have duly executed this Amendment as of the date first above
written. 
  

									
	WITNESS:	 		 	 LANDLORD:

		 		 	BRANDYWINE GRANDE C, L.P.
				
		 		 	By	 	 Brandywine Grande C Corp., its
 general
partner

					
		 		 		 	By:	 	 /s/ K. Suzanne Stumpf

	 /s/ K. Suzanne Stumpf
	 		 		 	Name:	 	K. Suzanne Stumpf
	K. Suzanne Stumpf	 		 		 	Title:	 	VP Asset Management
		 		 		 	Date:	 	4/20/07
			
	WITNESS:	 		 	TENANT:
		 		 	PPD DEVELOPMENT, LP
		 		 	By: PPD GP, LLC, Its General Partner
	 /s/ Charles H. Munn, Jr.
	 		 		 	
	Charles H. Munn, Jr.	 		 	By:	 	 /s/ Linda Baddour

		 		 	Name:	 	Linda Baddour
		 		 	Title:	 	Treasurer
		 		 	Date:	 	3/15/07Eighth Amendment dated March 1, 2006, to Lease Agreement, dated April 30, 2001

 Exhibit 10.254 
 EIGHTH AMENDMENT TO LEASE AGREEMENT 
 THIS EIGHTH AMENDMENT TO LEASE AGREEMENT (this
“Amendment”) is made and entered into this 1st day of March, 2006, by and between GREENWAY PROPERTIES, INC. (f.k.a. Western Center Properties, Inc.) (“Landlord”) and PPD DEVELOPMENT, LP (“Tenant”). 
 WITNESSETH: 
 WHEREAS, Tenant, through
PPD Development, LLC (Tenant’s predecessor in interest) and Landlord entered into a lease dated April, 30, 2001, as amended on August 15, 2001, August 25, 2003, March 22, 2004, May 17,
2004, December 14, 2004, June 3, 2004 and July 29, 2005 with respect to certain space located at 8551 Research Way, Middleton, Wisconsin (the lease, as so amended and as amended by this Amendment is referred to as the
“Lease”) in a building known as the Greenway Research Center (“Building”); and 
 WHEREAS, Landlord is the current owner
of the real estate which is the subject matter of the Lease; and 
 WHEREAS, the parties desire to amend the Lease as set forth herein;

 NOW, THEREFORE, in consideration of the mutual promises contained herein and for other good and valuable consideration, the receipt and
sufficiency of which is hereby acknowledged, it is agreed as follows: 
 1. Lease Extension. Modifying Section 1.9 of the Lease,
the term of the Lease shall expire on November 30, 2016, unless terminated sooner or extended as elsewhere provided in the Lease. 
 2.
Extension Commencement Date. The terms contained in this Amendment are effective March 1, 2006 (the “Extension Commencement Date”). 
 3. Definition of Premises. The term “Premises” as defined in Section 2.1 of the Lease shall include any and all Additional Space as defined in any amendment to the Lease effective now or
hereafter. At the execution of this Amendment, the Premises consist of 89,354 rentable square feet in the Building. 
 4. Monthly
Rent. Modifying Section 1.11 of the lease beginning with the Extension Commencement Date, the Monthly Rent (as defined in Section 4.1 of the Lease) for the Premises shall be Thirteen Dollars and Ninety Cents ($13.90) per rentable
square foot ($103,501.75 per month). 
 5. Monthly Rent Increases. Modifying Section 1.11 of the Lease, on each anniversary of
the Extension Commencement Date, the Monthly Rent shall increase three percent (3%), and that increased amount will be the Monthly Rent until the next anniversary of the Extension Commencement Date. 

 6. Right of First Refusal for ROFR Space. 
 (a) Beginning on the Extension Commencement Date, Tenant shall have a right of first refusal (the “Right of First Refusal”) to
lease any space that becomes available to lease within the Building (each a “ROFR Space”) provided that: 
 (i) The
Right of First Refusal will be subject and subordinate to the existing Right of First Offer held by LDS Nicolet (“LDS”) pursuant to the lease by and between LDS and Landlord dated May 21, 2004 for the space adjacent to LDS as
identified on Exhibit A; 
 (ii) This Lease is in full force and effect, and Tenant is and has been, at all times during the
term of the Lease, open and continuously operating in all of the Premises; 
 (iii) Tenant is not in default under the tell is
and conditions of this Lease at the time Tenant exercises the Right of First Refusal and shall not be in default on the date Tenant is supposed to take possession of the ROFR Space; and 
 (iv) Guarantor’s then-current financial condition, as revealed by its most recent financial statements, must demonstrate, in
Landlord’s reasonable discretion that Guarantor meets the financial criteria acceptable to Landlord. 
 (b) Landlord
shall give Tenant written notice (the “Landlord’s Notice”) of each ROFR Space that becomes available for lease. The Landlord’s Notice shall include the terms and conditions on which Landlord is prepared to lease the ROFR Space to
a bona fide third party lessee (the “Proposed Lease Terms”). 
 (c) To exercise this Right of First Refusal, Tenant
shall: 
 (i) Accept the Proposed Lease Terms in their entirety, without exception or amendment, by notifying Landlord, in
writing, within ten (10) business days after Tenant’s receipt of Landlord’s Notice, sent by registered or certified mail, return receipt requested, or a nationally recognized overnight courier, of Tenant’s intent to so accept;
and 
 (ii) Execute and deliver an amendment to this Lease, subjecting the ROFR Space to this Lease at the rent and for the
terms and conditions set forth in the Proposed Lease Terms) within five (5) business days after receipt of same from Landlord. 
 (d) Tenant acknowledges that time is of the essence with regard to this Right of First Refusal. If Tenant does not timely exercise its Right of First Refusal in strict compliance with the provisions of’ Section 6(c), then
(i) Landlord will have the unfettered right to lease the ROFR Space to a bona fide third party lessee generally on the Proposed Lease Terms and (ii) Landlords obligation to notify Tenant regarding the ROFR Space or offer the ROFR Space to
Tenant shall terminate, except as specifically provided in Section 6(e). 
  

 2 

 (e) If Landlord does not lease the ROFR Space to a bona fide third party lessee generally
in accordance with the Proposed Lease Terms described in Landlord’s Notice (i.e. there is a material change in the Proposed Lease Terms), then Tenant’s Right of First Refusal with respect to the ROFR Space shall be deemed revived and
Landlord shall offer the ROFR Space to Tenant under new Proposed Lease Terms under which Landlord is then willing to lease the ROFR Space to a bona fide third party lessee. 
 (f) This Right of First Refusal for ROFR Space is personal to the Tenant and is not transferable. 
 7. Option to Renew. 
 (a) Tenant shall have two (2) options (each a “Renewal Option”) to extend the term of the Lease for five (5) additional years each, at a fixed Monthly Rent equal to ninety-five percent (95%) of the then current
Market Rent (as herein defined). Each such five (5) year period is a “Renewal Term.” 
 (b) Provided Tenant is
not then in default under the Lease, Tenant shall have the right to exercise its Renewal Option to extend the term for the next Renewal Term by giving Landlord prior written notice of its intention to exercise the Renewal Option at least one hundred
eighty (180) days prior to the expiration of the initial term or the then current Renewal Term. 
 (c) Except as provided
in this Section 7, during any Renewal Term, all terms and conditions contained in the Lease shall remain the same except that after exercising the second Renewal Option, Tenant will have no further options to renew or extend the term of the
Lease. In addition, on the first day of each Renewal Term (each a “Renewal Commencement Date”), the Monthly Rent shall be recalculated to an amount that is ninety-five percent (95%) of the then current Market Rent. Thereafter, on each
anniversary of the Renewal Commencement Date, fixed Monthly Rent will increase three percent (3%) and that increased amount will be the Monthly Rent until the next anniversary of the Renewal Commencement Date. 
 (d) If Tenant exercises one or more of its Major Expansion Options (as defined below), then, notwithstanding any provisions in this Lease
to the contrary, Tenant’s exercise of each such Major Expansion Option will cause the term or the lease to be extended to the date that is ten (10) years after the date Landlord delivers the completed Major Expansion Space to Tenant.
Thereafter any Unused Renewal Options (as defined in Section 7(e)) may be exercised by Tenant in accordance with the provisions of this Lease. 
 (e) For the purposes of this Lease, Unused Renewal Options” shall be defined as provided for in this Section 7(e). 
 (i) If Tenant exercises a Major Expansion Option during the initial term of this Lease or during the first Renewal Term, then after the
expiration of the ten (10) year extension provided for Section 7(d), Tenant shall have two (2) complete Renewal Options to extend the term of the Lease for five (5) additional years each, all in accordance with the provisions of
this Section 7. 
  

 3 

 (ii) If Tenant exercises a Major Expansion Option during the second Renewal Term, then
after the expiration of the ten (10) year extension provided for in Section 7(d), Tenant shall have one (1) complete Renewal Option to extend the term of the Lease for five (5) additional years, all in accordance with the
provisions of this Section 7. 
 8. Market Rent. Market Rent shall be determined as follows: 
 (a) Within thirty (30) days following Tenant giving Landlord written notice of its intention to exercise its Renewal Option, Landlord
and Tenant shall each at their own expense, hire a commercial broker experienced with commercial leases in Dane County, and each such commercial broker shall, within fifteen (15) days, provide a fair market rent determination for the Premises
simultaneously to Landlord and Tenant (each a “Market Rent Determination”). 
 (b) If the two Market Rent
Determinations vary by less than five percent (5%) of the smaller of the two Market Rent Determinations, then ninety-five percent (95%) of the average of the two Market Rent Determinations shall be the Monthly Rent for the first year of
the Renewal Term. 
 (c) If the two Market Rent Determinations vary by five percent (5%) or more of the smaller of the
two Market Rent Determinations, then Landlord and Tenant may mutually agree to average the two Market Rent Determinations, in which event, the Monthly Rent for the first year of the Renewal Term will be ninety-five per cent (95%) of the average
of the two (2) Market Rent Determinations. If the parties cannot mutually agree to average the two Market Rent Determinations, then the parties shall engage a third commercial broker to assist with the determination of the fixed Monthly Rent
for the Renewal Term. If a third commercial broker is to be engaged, the two commercial brokers previously engaged shall jointly select a third commercial broker with experience in commercial leases in Dane County. The third commercial broker shall,
within fifteen (15) days after selection, provide a third Market Rent Determination for the Premises, in which event the Market Rent Determination for the Premises, in which event the Market Rent for the first year of the Renewal Term will be
ninety-live percent of the average of the three (3) Market Rent Determinations. All expenses related to the third commercial broker shall be shared equally between Landlord and Tenant. 
 9. Expansion Rights. Tenant shall have the Conditional Expansion Option provided for in Section 10, the South Expansion Option provided for
in Section 11, the West Expansion Option provided for in Section 12 and the North Expansion Option provided for in Section 13. The Conditional Expansion Option, the South Expansion Option, the West Expansion Option and the North
Expansion Option are collectively referred to in this Lease as a “Major Expansion Option.” 
  

 4 

 10. Conditional Expansion Option. 
 (a) Subject to the provisions of this Section 10, beginning on the Extension Commencement Date, Tenant shall have the option to lease
that certain space that (i) is located in the Building, adjacent to and south of the Premises, (ii) consists of approximately 10,801 rentable square feet of space, (iii) is currently leased by A-R Editions (“A-R”) pursuant
to that certain lease, dated October 1, 2000, between Landlord and A-R (the “A-R Lease”), and by vdw Design (`vdw”) pursuant to that certain lease, dated September 25, 2003, between Landlord and vdw (the “vdw
Lease”), and (iv) is generally depicted on Exhibit B attached hereto (collectively, the Conditional Expansion Space”) for exclusive use by Tenant (the “Conditional Expansion Option”) provided that: 
 (i) Landlord is able to relocate A-R and vdw to other premises pursuant to new leases that are acceptable to Landlord in Landlord’s
reasonable discretion, at a cost not to exceed $100,000.00, all as provided for in this Section 10. Relocation costs in excess of $100,000 would be Tenant’s responsibility; 
 (ii) This Lease is in full force and effect and Tenant is and has been, at all times during the term of the Lease, open and continuously
operating in all of the Premises; 
 (iii) Tenant is not in default under the terms and conditions of this Lease at the time
Tenant exercises the Conditional Expansion Option and shall not be in default when it is supposed to take possession of the Conditional Expansion Space; and 
 (iv) Guarantor’s then-current financial condition, as revealed by its most recent financial statements, must demonstrate, in
Landlord’s reasonable discretion that Guarantor meets the financial criteria acceptable to Landlord. 
 (v) Tenant
executes a lease amendment that is mutually acceptable to Landlord and Tenant in their reasonable discretion (the “Conditional Expansion Space Lease Amendment”) whereby Landlord agrees to lease the Conditional Expansion Space to
‘Tenant as part of the Premises, and Tenant agrees to lease the Conditional Expansion Space front Landlord as part of the Premises. Landlord and Tenant shall each negotiate any such Conditional Expansion Space Lease Amendment in good faith

 (b) To exercise this Conditional Expansion Option, Tenant shall give Landlord written notice (the “Tenant’s
Notice”) of its desire to lease the Conditional Expansion Space. 
  

 5 

 (c) After Tenant’s delivery of Tenant’s Notice, Landlord and Tenant shall enter
into the Conditional Expansion Space Lease Amendment. Landlord shall then use reasonable commercial efforts to cause A-R and vdw to relocate into other premises pursuant to new leases that are acceptable to Landlord in Landlord’s reasonable
discretion, provided however, that Tenant shall be responsible for any expenses in excess of $100,000 incurred by Landlord related to the relocation of A-R and/or vdw to other premises pursuant to Section 10. 
 (d) Landlord and Tenant acknowledge and agree that, notwithstanding any provision in this Lease to the contrary, Tenant’s Conditional
Expansion Option is conditioned upon and subject to A-R’s and vdw’s agreement to relocate to other premises, pursuant to new leases that are acceptable to Landlord in Landlord’s reasonable discretion. If, within ninety (90) days
after the date on which Landlord and Tenant agreed to the Conditional Expansion Space Lease Amendment, despite Landlord’s reasonable commercial efforts, A-R and vdw do not agree to relocate to other premises, pursuant to new leases that are
acceptable to Landlord in Landlord’s reasonable discretion, then Tenant’s rights under this Section 10 shall expire and have no further force or effect and the Conditional Expansion Space Lease Amendment shall become null and void.

 (e) The Conditional Expansion Space Lease Amendment shall include, but not be limited to the following provisions:

 (i) The base rent for the Conditional Expansion Space shall be equivalent to the base rent then being paid by Tenant for
the remainder of the Premises; 
 (ii) Upon completion of the construction of the Conditional Expansion Space, Tenant shall
pay costs and expenses for the Conditional Expansion Space as determined by Section 4.3 of the Lease; 
 (iii) Upon
completion of the construction of the Conditional Expansion Space, Tenant’s pro-rata share for common area expenses, as defined in Section 4.5 of the Lease, shall be adjusted accordingly to Tenant’s increased share of leased space in
the Building and the Conditional Expansion Space; 
 (iv) Beginning with the first day of the second year of the Conditional
Expansion Space Lease Amendment and each anniversary date thereafter, the base rent for the Conditional Expansion Space shall increase three percent (3%) per rear; 
 (v) Landlord shall provide Tenant with a Tenant Improvement Allowance of Ten dollars and no cents ($10.00) per rentable square foot within
the Conditional Expansion Space: and 
 (vi) Notwithstanding any provision in the Lease to the contrary, the term of the Lease
for the entire Premises, including without limitation, the Conditional Expansion Space, shall be extended to the date that is ten (10) years after the date the completed Conditional Expansion Space is delivered to Tenant. Thereafter, any
previous unused Renewal Options may be exercised effective as of the date that is ten (10) years after Landlord’s delivery of the Conditional Expansion Space to Tenant. 
  

 6 

 11. South Expansion Option. 
 (a) Beginning on the Extension Commencement Date, Tenant shall have a right to cause Landlord to commence and complete the construction of
a one-story or two-story addition containing no less than 10,000 square feet and no more than 22,000 square feet on the South side of the Conditional Expansion Space as depicted in Exhibit C (the “South Expansion Space”) for
exclusive use by Tenant (the “South Expansion Option”) provided that: 
 (i) Tenant has first acquired the
Conditional Expansion Space pursuant to the provisions of Section 10 above; 
 (ii) This Lease is in full force and
effect and Tenant is and has been, at all times during the term of the Lease, open and continuously operating in all of the Premises; 
 (iii) Tenant is not in default under the terms and conditions of this Lease at the time Tenant exercises the South Expansion Option and shall not be in default when it is supposed to take possession of the South
Expansion Space; 
 (iv) Landlord secures all permits and approvals necessary to construct and occupy the South Expansion
Space from all governmental authorities with jurisdiction over the Premises; 
 (v) Guarantor’s then-current financial
condition, as revealed by its most recent financial statements, must demonstrate, in Landlord’s reasonable discretion that Guarantor meets the financial criteria acceptable to Landlord; and 
 (vi) Prior to construction beginning on the South Expansion Space, Tenant executes a lease amendment that is mutually acceptable to
Landlord and Tenant in their reasonable discretion (the “South Expansion Space Lease Amendment”) whereby Landlord agrees to lease the South Expansion Space to Tenant as part of the Premises, and Tenant agrees to lease the South Expansion
Space from Landlord as part of the Premises. Landlord and Tenant shall each negotiate any such South Expansion Space Lease Amendment in good faith. 
 (b) Landlord and Tenant acknowledge and agree that if Landlord and Tenant, each acting in good faith, are unable to negotiate and agree to a South Expansion Space Lease Amendment under this Section 11(b) within
sixty (60) days after the date of Tenant’s Notice, then Tenant’s rights under this Section 11(b) shall expire and have no further force or effect. 
  

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 (c) The South Expansion Space building shell materials and architecture shall be
consistent with the existing Building and built in accordance with Landlord’s plans and specifications. 
 (d) Tenant
acknowledges and agrees that if Tenant has not first leased the Conditional Expansion Space pursuant to Section 10 above, that Tenant shall have no right or option to lease the South Expansion Space. 
 (e) To exercise this South Expansion Option, Tenant shall: 
 (i) Give Landlord written notice (the “Tenant’s Notice”) of its desire to lease the South Expansion Space; and 

(ii) Execute the South Expansion Space Lease Amendment as proposed by Landlord within thirty (30) business days after receipt of
the South Expansion Space Lease Amendment from Landlord. 
 (f) The South Expansion Space Lease Amendment shall include, but
not be limited to the following provisions: 
 (i) The base rent for the South Expansion Space shall be calculated by
multiplying the actual costs of the planning and construction of the South Expansion Space (the “Project Costs”) by the sum of the then prevailing five (5) year Treasury Note (as posted in the Wall Street Journal) plus 500 basis
points as of the date of the issuance of a building permit for the South Expansion Space; 
 (ii) Upon completion of the
construction of the South Expansion Space, Tenant shall pay costs and expenses for the South Expansion Space as determined by Section 4.3 of the Lease; 
 (iii) Upon completion of the construction of the South Expansion Space, Tenant’s pro-rata share for common area expenses, as defined
in Section 4.5 of the Lease, shall be adjusted accordingly to Tenant’s increased share of leased space in the Building and the South Expansion Space; 
 (iv) Beginning with the first day of the second year of the South Expansion Space Lease Amendment and each anniversary date thereafter,
the base rent for the South Expansion Space shall increase three percent (3%) per year; 
 (v) Project Costs shall
include all hard and soft costs, including a tenant improvement allowance of up to $50.00 per rentable square foot. In addition, Project Costs shall include Landlord’s cost of the North Land Parcel (see Exhibit F) and all costs necessary to
improve the North Land Parcel to accommodate the Building’s additional parking requirements due to the expansion: and 
  

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 (vi) Notwithstanding any provision in the Lease to the contrary, the term of the Lease
for the entire Premises, including without limitation, the South Expansion Space, shall be extended to the date that is ten (10) years after the date the completed South Expansion Space is delivered to Tenant. Thereafter, any previous unused
Renewal Options may be exercised effective as of the date that is ten (10) years after Landlord’s delivery of the South Expansion Space to Tenant. 
 12. West Expansion Option. 
 (a) Beginning on the Extension Commencement Date, Tenant
shall have a right to cause Landlord to commence and complete the construction of a one-story or two-story addition containing no less than 10,000 square feet and no more than 22,000 square feet on the west side of the Suite 90 as depicted in
Exhibit D (the “West Expansion Space”) for exclusive use by Tenant (the “West Expansion Option”) provided that: 
 (i) This Lease is in full force and effect and Tenant is and has been, at all times during the term of the Lease, open and continuously operating in all of the Premises; 
 (ii) Tenant is not in default under the terms and conditions of this Lease at the time Tenant exercises the West Expansion Option and
shall not be in default when it is supposed to take possession of the West Expansion Space; 
 (iii) Landlord secures all
permits and approvals necessary to construct and occupy the West Expansion Space from all governmental authorities with jurisdiction over the Premises; 
 (iv) Prior to construction beginning on the West Expansion Space, Tenant executes a lease amendment that is mutually acceptable to Landlord and Tenant in their reasonable discretion (the “West Expansion Space
Lease Amendment”) whereby Landlord agrees to lease the West Expansion Space to Tenant as part of the Premises, and Tenant agrees to lease the West Expansion Space from Landlord as part of the Premises. Landlord and Tenant shall each negotiate
any such West Expansion Space Lease Amendment in good faith; and 
 (v) Guarantor’s then-current financial condition, as
revealed by its most recent financial statements, must demonstrate, in Landlord’s reasonable discretion that Guarantor meets the financial criteria acceptable to Landlord. 
 (b) Landlord and Tenant acknowledge and agree that if Landlord and Tenant, each acting in good faith, are unable to negotiate and agree to
a West Expansion Space Lease Amendment under this Section 12(b) within sixty (60) days after the date of Tenant’s Notice, then Tenant’s rights under this Section 12(b) shall expire and have no further force or effect.

  

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 (c) The West Expansion Space building shell materials and architecture shall be
consistent with the existing Building and built in accordance with Landlord’s plans and specifications. 
 (d) To
exercise this West Expansion Option, Tenant shall: 
 (i) Give Landlord written notice (the “Tenant’s Notice”)
of its desire to lease the West Expansion Space; and 
 (ii) Execute the West Expansion Space Lease Amendment as proposed by
Landlord within thirty (30) business days after receipt of the West Expansion Space Lease Amendment from Landlord. 
 (e)
The West Expansion Space Lease Amendment shall include, but not be limited to the following provisions: 
 (i) The base rent
for the West Expansion Space shall be calculated by multiplying the actual costs of the planning and construction of the West Expansion Space (the “Project Costs”) by the sum of the then prevailing five (5) year Treasury Note (as
posted in the Wall Street Journal) plus 500 basis points as of the date of the issuance of a building permit for the West Expansion Space; 
 (ii) Upon completion of the construction of the West Expansion Space, Tenant shall pay costs and expenses for the West Expansion Space as determined by Section 4.3 of the Lease; 
 (iii) Upon completion of the construction of the West Expansion Space, Tenant’s pro-rata share for common area expenses, as defined
in Section 4.5 of the Lease, shall be adjusted accordingly to Tenant’s increased share of leased space in the Building and the West Expansion Space; 
 (iv) Beginning with the first day of the second year of the West Expansion Space Lease Amendment and each anniversary date thereafter, the
base rent for the West Expansion Space shall increase three percent (3%) per year; 
 (v) Project Costs shall include all
hard and soft costs, including a tenant improvement allowance of up to $50.00 per rentable square foot, excluding any attributed land value. In addition, Project Costs shall include Landlord’s cost of the Ninth Land Parcel (see Exhibit F) and
all costs necessary to improve the worth hand Parcel to accommodate the Building’s additional parking requirements due to the expansion, and 
 (vi) Notwithstanding any provision in the Lease to the contrary, the term or the Lease for the entire Premises, including without limitation, the West Expansion Space, shall be extended to the date that is ten
(10) years after the date the completed West Expansion Space is delivered to Tenant. Thereafter, any previous unused Renewal Options may be exercised effective as of the date that is ten (10) years after Landlord’s delivery of the
West Expansion Space to Tenant. 
  

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 13. North Expansion Option. 
 (a) Beginning on the Extension Commencement Date, Tenant shall have a right to cause Landlord to commence and complete the construction of
a one-story or two-story addition containing no less than 10,000 square feet and no more than 22,000 square feet on the north side of the Suite 90 as depicted in Exhibit E (the “North Expansion Space”) for exclusive use by Tenant
(the “North Expansion Option”) provided that: 
 (i) This Lease is in full force and effect and Tenant is and has
been, at all times during the term of the Lease, open and continuously operating in all of the Premises; 
 (ii) Tenant is not
in default under the terms and conditions of this Lease at the time Tenant exercises the North Expansion Option and shall not be in default when it is supposed to take possession of the North Expansion Space; 
 (iii) Landlord secures all permits and approvals necessary to construct and occupy the North Expansion Space from all governmental
authorities with jurisdiction over the Premises; 
 (iv) Prior to construction beginning on the North Expansion Space, Tenant
executes a lease amendment that is mutually acceptable to Landlord and Tenant in their reasonable discretion (the “North Expansion Space Lease Amendment”) whereby Landlord agrees to lease the North Expansion Space to Tenant as part of the
Premises, and Tenant agrees to lease the North Expansion Space from Landlord as part of the Premises. Landlord and Tenant shall each negotiate any such North Expansion Space Lease Amendment in good faith; and 
 (v) Guarantor’s then-current financial condition, as revealed by its most recent financial statements, must demonstrate, in
Landlord’s reasonable discretion that Guarantor meets the financial criteria acceptable to Landlord. 
 (b) Landlord and
Tenant acknowledge and agree that if Landlord and Tenant, each acting in good faith, are unable to negotiate and agree to a North Expansion Space Lease Amendment under this Section 13(b) within sixty (60) days after the date of
Tenant’s Notice, then Tenant’s rights under this Section 13(b) shall expire and have no further force or effect. 
 (c) The North Expansion Space building shell materials and architecture shall be consistent with the existing Building and built in accordance with Landlord’s plans and specifications. 
  

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 (d) To exercise this North Expansion Option, Tenant shall: 
 (i) Give Landlord written notice (the “Tenant’s Notice”) of its desire to lease the North Expansion Space; and 

(ii) Execute the North Expansion Space Lease Amendment as proposed by Landlord within thirty (30) business days after receipt of
the North Expansion Space Lease Amendment from Landlord. 
 (e) The North Expansion Space Lease Amendment shall include, but
not be limited to the following provisions: 
 (i) The base rent for the North Expansion Space shall be calculated by
multiplying the actual costs of the planning and construction of the North Expansion Space (the “Project Costs”) by the sum of the then prevailing five (5) year Treasury Note (as posted in the Wall Street Journal) plus 500 basis
points as of the date of the issuance of a building permit for the North Expansion Space; 
 (ii) Upon completion of the
construction of the North Expansion Space, Tenant shall pay costs and expenses for the North Expansion Space as determined by Section 4.3 of the Lease; 
 (iii) Upon completion of the construction of the North Expansion Space, Tenant’s pro-rata share for common area expenses, as defined
in Section 4.5 of the Lease, shall be adjusted accordingly to Tenant’s increased share of leased space in the Building and the North Expansion Space; 
 (iv) Beginning with the first day of the second year of the North Expansion Space Lease Amendment and each anniversary date thereafter,
the base rent for the North Expansion Space shall increase three percent (3%) per year; 
 (v) Project Costs shall
include all hard and soft costs, including a tenant improvement allowance of up to $50.00 per rentable square foot, excluding any attributed land value. In addition, Project Costs shall include Landlord’s cost of the North Land Parcel (see
Exhibit F) and all costs necessary to improve the North Land Parcel to accommodate the Building’s additional parking requirements due to the expansion; and 
 (vi) Notwithstanding any provision in the Lease to the contrary, the term of the Lease for the entire Premises, including without
limitation, the North Expansion Space, shall be extended to the date that is ten (10) years after the date the completed North Expansion Space is delivered to the Tenant. Thereafter, any previous unused Renewal Options may be exercised
effective as of the date that is ten (10) years after Landlord’s delivery of the North Expansion Space to Tenant 
 14. Tenant
Improvements. Landlord grants Tenant the following rights with respect to tenant improvements in the Conditional Expansion Space, South Expansion Space, West Expansion Space and North Expansion Space: 
 (a) To independently manage any Tenant space design and build-out. 
  

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 (b) To select, at its own discretion, all consultants and vendors including architects,
engineers, consultants, construction manager, contractors and subcontractors. 
 (c) Landlord shall not specify any
subcontractors, unless the additional cost of such subcontractors is borne by the Landlord. 
 (d) There will be no Landlord
supervision fees or any other hidden Landlord fees. 
 (e) In the event Tenant does not utilize the entire allowance, any
residual shall be credited to Tenant in the equivalent rental abatement, cash, or rent reduction at Tenant’s request. 
 (f) Tenant may custom design and build the space and may not necessarily use building standards, so long as such design has no adverse impact on common areas or other tenants’ premises. 
 (g) In the event Landlord constructs the Tenant Improvements, Tenant shall have the right to review and audit all costs of the
construction of the Tenant Improvements to ensure costs are accurate and reasonable. 
 15. Alterations. Subject to Section 5.1
of the Lease, Tenant shall have the right, upon thirty (30) days prior written notice to Landlord, at its own expense, to make any repairs or renovations to the Premises that do not affect the structure, mechanical systems or electrical systems
of the Building in an amount up to $250,000 (“Alteration Limit”) without Landlord’s consent. The Alteration Limit excludes costs attributable to furniture, fixtures, and equipment. In all cases, Tenant shall provide Landlord a copy of
all architectural drawings of such Alterations at least thirty (30) days prior to the date the Alterations are initiated. 
 16.
Use. Modifying Section 8.1 of the Lease, Tenant may use the Premises for any and all lawful purposes, including but not limited to general office, laboratory, medical research and warehouse and distribution, to the extent that such use
does not constitute a nuisance for other Building tenants. 
 17. Access. Tenant’s employees shall have access to the Premises
twenty-four (24) hours per day, seven (7) days per week. 
 18. Full Force and Effect; Miscellaneous. Except as specifically
amended herein, the Lease is hereby ratified and affirmed and shall remain in full force and effect. Capitalized definitional terms used, but not defined, herein shall have the same meanings as are given to such terms in the Lease. Each party
acknowledges that the other party is not in default under this Lease nor does either party know of any circumstance that, with the giving of notice, would result in the other party being in default under this Lease. 
  

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 19. Conflict. If there is a conflict between provisions of the Lease and this Amendment, the
provisions of this Amendment shall control. 
 20. Capitalized Terms. Capitalized terms used but not otherwise defined in this
Amendment shall be assigned the definition assigned to those terms in the Lease. 
 21. Lease Guaranty. This Lease shall be guaranteed
by tenant’s parent company Pharmaceutical Product Development, Inc (NASDAQ Symbol “PPDI”), as set forth in Exhibit G to this Eighth Amendment to Lease Agreement. 
 22. Estoppel Certificate. Tenant agrees, within ten (10) days after written request from Landlord, to execute in recordable form and deliver
to Landlord a statement, in writing, certifying, if such is the case: (a) that the Lease is unmodified and in full force and effect; (b) the Lease commencement date; (c) that Rent is paid currently without any offsets; (d) the
amount of Rent, if any, paid in advance; and (e) that Tenant has no defenses, offsets or counterclaims against its obligations to pay Rent and perform its other covenants under the Lease and that there are no uncured defaults by Landlord, or
stating those claimed by Tenant. Failure of Tenant to execute the above instrument within ten (10) days after written request to do so by Landlord shall constitute a breach of the Lease, and Landlord may, at its option, seek damages of $100 per
day extending beyond the 10-day period outlined herein. 
 IN WITNESS WHEREOF, the undersigned have executed this Amendment on the day and
year first above written. 
  

									
	 LANDLORD:
 Greenway Properties, Inc.

 (f.k.a. Western Center Properties, Inc.)
 a Wisconsin
Corporation
	 		 	 TENANT:
 PPD Development,
LP
 By: PPD GP, LLC, General Partner

					
	By:	 	

	 		 	By:	 	

		 	Scott L.Berger	 		 		 	Fred B.Davenport Jr.
		 	Vice President	 		 		 	President

  

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