Document:

Form of Medium-Term Notes, Series K

 Exhibit 4.1 

[Face of Note] 

Unless this certificate is presented by an authorized representative of The Depository Trust Company, a New York corporation
(“DTC”), to the Company or its agent for registration of transfer, exchange or payment, and any certificate issued is registered in the name of Cede & Co. or in such other name as requested by an authorized representative
of DTC (and any payment is made to Cede & Co. or such other entity as is requested by an authorized representative of DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL inasmuch as the
registered owner hereof, Cede & Co., has an interest herein. 
  

	 CUSIP NO. 94986RZH7 
	 PRINCIPAL AMOUNT: $____________ 

REGISTERED NO. ___ 
 WELLS FARGO &
COMPANY 
 MEDIUM-TERM NOTE, SERIES K 

Due Nine Months or More From Date of Issue 

Notes due October 16, 2020 

WELLS FARGO & COMPANY, a corporation duly organized and existing under the laws of the State of Delaware (hereinafter
called the “Company,” which term includes any successor corporation under the Indenture hereinafter referred to), for value received, hereby promises to pay to CEDE & Co., or registered assigns, the principal sum of
_________________________________ DOLLARS ($___________) on October 16, 2020 (the “Stated Maturity Date”) and to pay interest thereon from October 16, 2015 or from the most recent Interest Payment Date to which interest
has been paid or duly provided for semi-annually on each April 16 and October 16, commencing April 16, 2016 and at Maturity (each, an “Interest Payment Date”), at the rate per annum specified below until the principal
hereof is paid or made available for payment. The interest so payable, and punctually paid or duly provided for, on any Interest Payment Date will, as provided in the Indenture, be paid to the Person in whose name this Security (or one or more
Predecessor Securities) is registered at the close of business on the Regular Record Date for such interest next preceding such Interest Payment Date. The Regular Record Date for an Interest Payment Date shall be one Business Day prior to such
Interest Payment Date. If an Interest Payment Date is not a Business Day, interest on this Security shall be payable on the next day that is a Business Day, with the same force and effect as if made on such Interest Payment Date, and without any
interest or other payment with respect to the delay. “Business Day” shall mean a day, other than a Saturday or Sunday, that is neither a legal holiday nor a day on which banking institutions are authorized or required by law or
regulation to close in New York, New York. 
 Except as described below for the first Interest Period, on each Interest
Payment Date, interest will be paid for the period commencing on and including the immediately preceding Interest Payment Date and ending on and including the day immediately preceding that Interest 

 
Payment Date. This period is referred to as an “Interest Period.” The first Interest Period will commence on and include October 16, 2015 and end on and include
April 15, 2016. Interest on this Security will be computed on the basis of a 360-day year of twelve 30-day months. 

The interest rate on this Security that will apply during an Interest Period will be as follows: 

 

					
	 Commencing October 16, 2015 and

ending October 15, 2018
	  	 	1.75% per annum	  
	 Commencing October 16, 2018 and

ending October 15, 2019
	  	 	2.50% per annum	  
	 Commencing October 16, 2019 and

ending October 15, 2020
	  	 	3.50% per annum	  

 Any interest not punctually paid or duly provided for will forthwith cease to be payable to
the Holder on such Regular Record Date and may either be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on a Special Record Date for the payment of such Defaulted
Interest to be fixed by the Trustee, notice whereof shall be given to Holders of Securities of this series not less than 10 days prior to such Special Record Date, or be paid at any time in any other lawful manner not inconsistent with the
requirements of any securities exchange on which the Securities of this series may be listed, and upon such notice as may be required by such exchange, all as more fully provided in the Indenture. 

Payment of interest on this Security will be made in immediately available funds at the office or agency of the Company
maintained for that purpose in the City of Minneapolis, Minnesota in such coin or currency of the United States of America as at the time of payment is legal tender for payment of public and private debts; provided, however, that, at the option of
the Company, payment of interest may be paid by check mailed to the Person entitled thereto at such Person’s last address as it appears in the Security Register or by wire transfer to such account as may have been designated by such Person.
Payment of principal of and interest on this Security at Maturity will be made against presentation of this Security at the office or agency of the Company maintained for that purpose in the City of Minneapolis, Minnesota. Notwithstanding the
foregoing, for so long as this Security is a Global Security registered in the name of the Depositary, payments of principal and interest on this Security will be made to the Depositary by wire transfer of immediately available funds. 

This Security is redeemable at the option of the Company, in whole but not in part, on any Optional Redemption Date occurring
on or after October 16, 2018 at a Redemption Price equal to 100% of the principal amount of this Security to be redeemed, plus any accrued but unpaid interest to, but excluding, the Redemption Date. The “Optional Redemption Dates” are
the 16th of each January, April, July and October, beginning October 16, 2018 and ending July 16, 2020. Notice of any redemption will be mailed at least 5 but not more than 30 days
before the applicable Redemption Date to the Holder hereof. Unless the Company defaults in the payment of the Redemption Price, on or after the Redemption Date, interest will cease to accrue on this Security or the portion hereof called for
redemption. 

  
 2 

 This Security is not subject to repayment at the option of the Holder hereof
prior to October 16, 2020. This Security is not entitled to any sinking fund. 
 Reference is hereby made to the
further provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect as if set forth at this place. 

Unless the certificate of authentication hereon has been executed by the Trustee referred to on the reverse hereof by manual
signature or its duly authorized agent under the Indenture referred to on the reverse hereof by manual signature, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose. 

[The remainder of this page has been left intentionally blank] 

  
 3 

 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed
under its corporate seal. 
 DATED: ______________ 
  

					
	WELLS FARGO & COMPANY
		
	By:	 	 
		 	 
		 	Its:	 	 

 [SEAL] 
  

					
	Attest:	 	 
		 	 
		 	Its:	 	 

  

			
	 TRUSTEE’S CERTIFICATE OF

AUTHENTICATION
 This is one of the Securities of the

series designated therein described
 in the within-mentioned Indenture.

	
	 CITIBANK, N.A.,

      as Trustee

		
	By:	 	 
		 	Authorized Signature
	
	OR
	
	 WELLS FARGO BANK, N.A.,

  as Authenticating Agent for the Trustee

		
	By:	 	 
		 	Authorized Signature

  
 4 

 [Reverse of Note] 

WELLS FARGO & COMPANY 

MEDIUM-TERM NOTE, SERIES K 

Due Nine Months or More From Date of Issue 

Notes due October 16, 2020 

This Security is one of a duly authorized issue of securities of the Company (herein called the
“Securities”), issued and to be issued in one or more series under an indenture dated as of July 21, 1999, as amended or supplemented from time to time (herein called the “Indenture”), between the Company and
Citibank, N.A., as Trustee (herein called the “Trustee,” which term includes any successor trustee under the Indenture), to which Indenture and all indentures supplemental thereto reference is hereby made for a statement of the
respective rights, limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities, and of the terms upon which the Securities are, and are to be, authenticated and delivered. This Security is
one of the series of the Securities designated as Medium-Term Notes, Series K, of the Company, which series is limited to an aggregate principal amount or face amount, as applicable, of $25,000,000,000 or the equivalent thereof in one or more
foreign or composite currencies. The amount payable on the Securities of this series may be determined by reference to the performance of one or more equity-, commodity- or currency-based indices, exchange traded funds, securities, commodities,
currencies, statistical measures of economic or financial performance, or a basket comprised of two or more of the foregoing, or any other market measure or may bear interest at a fixed rate or a floating rate. The Securities of this series may
mature at different times, be redeemable at different times or not at all, be repayable at the option of the Holder at different times or not at all and be denominated in different currencies. 

Article Sixteen of the Indenture shall not apply to this Security. 

The Securities are issuable only in registered form without coupons and will be either
(a) book-entry securities represented by one or more Global Securities recorded in the book-entry system maintained by the Depositary or (b) certificated
securities issued to and registered in the names of, the beneficial owners or their nominees. 
 The Company agrees, to the
extent permitted by law, not to voluntarily claim the benefits of any laws concerning usurious rates of interest against a Holder of this Security. 

Modification and Waivers 

The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the modification of the rights
and obligations of the Company and the rights of the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and the Trustee with the consent of the Holders of a majority in principal amount of the
Securities at the time Outstanding of all series to be affected, acting together as a class. The Indenture also contains 

  
 5 

 
provisions permitting the Holders of a majority in principal amount of the Securities of all series at the time Outstanding affected by certain provisions of the Indenture, acting together as a
class, on behalf of the Holders of all Securities of such series, to waive compliance by the Company with those provisions of the Indenture. Certain past defaults under the Indenture and their consequences may be waived under the Indenture by the
Holders of a majority in principal amount of the Securities of each series at the time Outstanding, on behalf of the Holders of all Securities of such series. Any such consent or waiver by the Holder of this Security shall be conclusive and binding
upon such Holder and upon all future Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation of such consent or waiver is made upon this Security.

 Defeasance 

Section 403 and Article Fifteen of the Indenture and the provisions of clause (ii) of Section 401(1)(B) of the
Indenture, relating to defeasance at any time of (a) the entire indebtedness on this Security and (b) certain restrictive covenants and certain Events of Default, upon compliance by the Company with certain conditions set forth therein,
shall not apply to this Security. The remaining provisions of Section 401 of the Indenture shall apply to this Security. 
 Authorized
Denominations 
 This Security is issuable only in registered form without coupons in denominations of $1,000 or any
amount in excess thereof which is an integral multiple of $1,000. 
 Registration of Transfer 

Upon due presentment for registration of transfer of this Security at the office or agency of the Company in the City of
Minneapolis, Minnesota, a new Security or Securities of this series, with the same terms as this Security, in authorized denominations for an equal aggregate principal amount will be issued to the transferee in exchange herefor, as provided in the
Indenture and subject to the limitations provided therein and to the limitations described below, without charge except for any tax or other governmental charge imposed in connection therewith. 

This Security is exchangeable for definitive Securities in registered form only if (x) the Depositary notifies the
Company that it is unwilling or unable to continue as Depositary for this Security or if at any time the Depositary ceases to be a clearing agency registered under the Securities Exchange Act of 1934, as amended, and a successor depositary is not
appointed within 90 days after the Company receives such notice or becomes aware of such ineligibility, (y) the Company in its sole discretion determines that this Security shall be exchangeable for definitive Securities in registered form
and notifies the Trustee thereof or (z) an Event of Default with respect to the Securities represented hereby has occurred and is continuing. If this Security is exchangeable pursuant to the preceding sentence, it shall be exchangeable for
definitive Securities in registered form, bearing interest at the same rate, having the same date of issuance, Stated Maturity Date and other terms and of authorized denominations aggregating a like amount. 

This Security may not be transferred except as a whole by the Depositary to a nominee of the Depositary or by a nominee of the
Depositary to the Depositary or another nominee of the Depositary or by the Depositary or any such nominee to a successor of the Depositary or a nominee 

  
 6 

 
of such successor. Except as provided above, owners of beneficial interests in this Global Security will not be entitled to receive physical delivery of Securities in definitive form and will not
be considered the Holders hereof for any purpose under the Indenture. 
 Prior to due presentment of this Security for
registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither
the Company, the Trustee nor any such agent shall be affected by notice to the contrary. 
 Obligation of the Company Absolute 

No reference herein to the Indenture and no provision of this Security or the Indenture shall alter or impair the obligation
of the Company, which is absolute and unconditional, to pay the principal of and interest on this Security at the times, place and rate, and in the coin or currency, herein prescribed, except as otherwise provided in this Security. 

No Personal Recourse 

No recourse shall be had for the payment of the principal of or the interest on this Security, or for any claim based hereon,
or otherwise in respect hereof, or based on or in respect of the Indenture or any indenture supplemental thereto, against any incorporator, stockholder, officer or director, as such, past, present or future, of the Company or any successor
corporation, whether by virtue of any constitution, statute or rule of law, or by the enforcement of any assessment or penalty or otherwise, all such liability being, by the acceptance hereof and as part of the consideration for the issuance hereof,
expressly waived and released. 
 Defined Terms 

All terms used in this Security which are defined in the Indenture shall have the meanings assigned to them in the Indenture
unless otherwise defined in this Security. 
 Governing Law 

This Security shall be governed by and construed in accordance with the law of the State of New York, without regard to
principles of conflicts of laws. 

  
 7 

 ABBREVIATIONS 

The following abbreviations, when used in the inscription on the face of this instrument, shall be construed as though they
were written out in full according to applicable laws or regulations: 
  

					
	 TEN COM
	 	  -- 
	 	 as tenants in common

			
	 TEN ENT
	 	  -- 
	 	 as tenants by the entireties

			
	 JT TEN
	 	  -- 
	 	 as joint tenants with right

of survivorship and not
 as
tenants in common

  

									
	 UNIF GIFT MIN ACT
	 	  -- 
	 	 	 	 Custodian
	 	 
		 		 	(Cust)	 		 	(Minor)

  

	
	Under Uniform Gifts to Minors Act
	
	   

	(State)

 Additional abbreviations may also be used though not in the above list. 

FOR VALUE RECEIVED, the undersigned hereby sell(s) and transfer(s) unto 

 

	
	 Please Insert Social Security or
 Other
Identifying Number of Assignee

	
	   

  
  

 
  
  

 
 (PLEASE
PRINT OR TYPE NAME AND ADDRESS INCLUDING POSTAL ZIP CODE OF ASSIGNEE)

  
 8 

 the within Security of WELLS FARGO & COMPANY and does hereby irrevocably constitute and
appoint __________________ attorney to transfer the said Security on the books of the Company, with full power of substitution in the premises. 
 Dated:
_________________________ 
  

	
	   

  

	
	   

 NOTICE: The signature to this assignment must correspond with the name as written upon the face of the
within instrument in every particular, without alteration or enlargement or any change whatever. 

  
 9EX-10.1

 Exhibit 10.1 

THIRD AMENDMENT TO CREDIT AGREEMENT 

This THIRD AMENDMENT TO CREDIT AGREEMENT (this “Amendment”) is made and entered into as of October 13, 2015 by and among
UNILIFE MEDICAL SOLUTIONS, INC., a Delaware corporation (the “Borrower”), the other Creditor Obligors party hereto and ROS ACQUISITION OFFSHORE LP, a Cayman Islands exempted limited partnership (in its capacity as Lender and
Collateral Agent, the “Lender”). 
 WHEREAS, the Borrower and the Lender are party to that certain Credit Agreement,
dated as of March 12, 2014 (as amended on September 30, 2014 and June 30, 2015, and as further amended from time to time, the “Credit Agreement”), pursuant to which the Lender has extended credit to the Borrower on
the terms set forth therein; 
 WHEREAS, the Lender has agreed to consider requests for additional draws under the Credit Agreement
in an aggregate amount not to exceed $10,000,000 in its sole discretion on the terms and conditions set forth herein and in the Credit Agreement; 

WHEREAS, the Borrower has requested that the Lender amend the Credit Agreement, as more fully described herein; and 

WHEREAS, the Lender is willing to agree to such amendment, but only upon the terms and subject to the conditions set forth herein.

 NOW, THEREFORE, in consideration of the mutual agreements herein contained, and for other good and valuable consideration, the
receipt and sufficiency of which are hereby acknowledged, the parties hereto agree as follows: 
 1. Definitions; Loan Document.
Capitalized terms used herein without definition shall have the meanings assigned to such terms in the Credit Agreement. This Amendment and the amended and restated Note delivered in connection herewith shall constitute Loan Documents for all
purposes of the Credit Agreement and the other Loan Documents. Each reference to “hereof”, “hereunder”, “herein” and “hereby” and each other similar reference and each reference to “this Agreement”
and each other similar reference contained in the Credit Agreement shall, after this Amendment becomes effective, refer to the Credit Agreement as amended hereby. 

2. Amendments. 
 (a)
Section 1.1 of the Credit Agreement is hereby amended by adding the following definitions in alphabetical order: 
 “Additional
Delayed Draw Closing Dates” means the date of the making of each Additional Delayed Draw Loan hereunder. 
 “Additional
Delayed Draw Commitment Amount” means $10,000,000. 
 “Additional Delayed Draw Loan” is defined in
Section 2.5. 

 (b) The following definitions in Section 1.1 of the Credit Agreement are hereby amended and
restated in their entirety as follows: 
 “Commitment Amount” means the Initial Commitment Amount, plus the Delayed Draw
Commitment Amount, plus the Additional Delayed Draw Commitment Amount. 
 “Loans” means the Initial Loan, each Delayed Draw
Loan and each Additional Delayed Draw Loan. 
 (c) Article II is hereby amended by adding the following as a new Section 2.5: 

SECTION 2.5 Additional Delayed Draw Loans. 

(a) On the terms and subject to the conditions of this Agreement, the Lender may, in its sole discretion, make term loans
(each, an “Additional Delayed Draw Loan”) to the Borrower on each Additional Delayed Draw Closing Date in an amount determined by Lender (but in no event shall the aggregate amount of all such Additional Delayed Draw Loans exceed
the Additional Delayed Draw Commitment Amount). 
 (b) The Borrower shall irrevocably request that the Additional Delayed
Draw Loan be made by delivering to the Lender a Loan Request on or before 4:00 p.m. Eastern Time on a Tuesday and at least two Business Days prior to each Additional Delayed Draw Closing Date. 

(c) The Lender may, in its sole discretion, on each Additional Delayed Draw Closing Date and subject to the terms and
conditions hereof, make the Additional Delayed Draw Loan in the amount determined by Lender, but not greater than the amount requested in the applicable Loan Request, available to the Borrower by wire transfer to the account the Borrower shall have
specified in its Loan Request. 
 (d) Section 3.2(d) is hereby amended and restated in its entirety as follows: 

(d) Amounts repaid or prepaid in respect of the outstanding principal amount of the Loans shall be applied pro rata to the
Initial Loan, each Delayed Draw Loan and each Additional Delayed Draw Loan. 

  
 -2- 

 (e) Article V is hereby amended by adding the following as a new Section 5.30: 

SECTION 5.30 Conditions to Additional Delayed Draw Loans. The making of each Additional Delayed Draw Loan by the
Lender shall be in the sole discretion of the Lender and subject to the satisfaction (or waiver in writing by the Lender) of each of the following conditions precedent and such other conditions as Lender may require in its sole discretion: 

(a) The Lender shall have received a Closing Certificate, dated as of the Additional Delayed Draw Closing Date, as the case may
be, and duly executed and delivered by an Authorized Officer of the Borrower, in which certificate the Borrower shall agree and acknowledge that the statements made therein shall be deemed to be true and correct representations and warranties of the
Borrower as of such date, and, at the time such certificate is delivered, such statements shall in fact be true and correct, and such statements shall include that except as disclosed in the disclosure letter dated the date hereof and delivered to
the Lender on the date hereof (i) the representations and warranties set forth in each Loan Document (other than Section 6.14 of the Credit Agreement) shall, in each case, be true and correct in all respects (in the case of any
representation or warranty qualified by materiality or Material Adverse Effect) or in all material respects (in the case of any representation or warranty not qualified by materiality or Material Adverse Effect), before and after giving effect to
the making of the Additional Delayed Draw Loan and to the application of the proceeds thereof, as though made on and as of the date hereof, (ii) no Default shall have then occurred and be continuing, or would result from the Loan to be advanced
on the Additional Delayed Draw Closing Date, as the case may be, and (c) all of the conditions set forth in Section 5.30 have been satisfied. All documents and agreements required to be appended to the Closing Certificate, if any, shall be
in form and substance reasonably satisfactory to the Lender, shall have been executed and delivered by the requisite parties, and shall be in full force and effect. 

(b) The Borrower shall have delivered a Loan Request to the Lender as required pursuant to Section 2.5, and immediately
prior to each Additional Delayed Draw Closing Date, the Borrower shall have delivered to the Lender updates to Schedules 6.15(a), 6.16 and 6.22, each such updated Schedule to be complete and accurate in all material respects as of such Additional
Delayed Draw Closing Date. 
 (c) All documents executed or submitted pursuant hereto by or on behalf of Holdings, the
Borrower or any Subsidiary shall be satisfactory in form and substance to the Lender and its counsel, and the Lender and its counsel shall have received all information, approvals, resolutions, opinions, documents or instruments as the Lender or its
counsel may reasonably request. 
 (f) The introductory paragraph of Article VI is hereby amended by replacing the phrase “Closing Date
and on each Delayed Draw Closing Date” with “Closing Date, on each Delayed Draw Closing Date and on each Additional Delayed Draw Closing Date”. 

(g) Each of Section 6.15(a), Section 6.16 and Section 6.22 is hereby amended by replacing the phrase “Closing Date or
Delayed Draw Closing Date” in each such section with “Closing Date, Delayed Draw Closing Date or Additional Delayed Draw Closing Date”. 

  
 -3- 

 (h) Section 7.1 is hereby amended by (i) deleting “and” at the end of
Section 7.1(m), (ii) replacing the period at the end of Section 7.1(n) with “; and”, and (iii) adding the following as a new Section 7.1(o): 

(o) by 4:00 p.m. Eastern Time on each Monday, commencing October 12, 2015, a weekly budget for the following three months
after the Additional Delayed Draw Closing Date, including in comparative form the figures and performance from the prior weeks’ budgets (other than for the first such week’s budget), in form and substance satisfactory to Lender; provided
that the first weekly budget shall go through December 31, 2015. 
 (i) Article VII is hereby amended by adding the following as new
Section 7.15: 
 SECTION 7.15 Board Observation Rights. 

(a) The Borrower shall permit two (2) persons representing the Lender (the “Observers”) to attend and
observe (but not vote) at all meetings of Holdings’ (or the Borrower’s or the Subsidiaries’, as applicable) board of directors and any committee thereof, whether in person, by telephone or otherwise. The Borrower shall, except with
respect to emergency meetings of such boards of directors or any committee thereof, notify the Observers in writing at least three (3) Business Days in advance of (i) the date and time for each general or special meeting of such boards of
directors or any committee thereof and (ii) the adoption of any resolutions or actions by written consent (describing, in reasonable detail, the nature and substance of such action). The general meetings shall take place on no less than a
quarterly basis. The Borrower shall concurrently deliver to the Observers all notices and any materials delivered to the boards of directors or any committees thereof in connection with a board meeting or action to be taken by written consent,
including a draft of any material resolutions or actions proposed to be adopted by written consent. Any such materials delivered to the Observers shall also be delivered by the Borrower to the Lender. The Observers shall be free prior to such
meeting or adoption by consent to contact the board of directors and discuss the pending actions to be taken. The Observers shall be notified of emergency meetings of such boards of directors and any committee thereof within substantially the same
amount of time as the directors of such boards or members of any such committee. 
 (b) The Borrower shall pay the
Observers’ reasonable out-of-pocket expenses (including the cost of travel, meals and lodging) in connection with the attendance of such meetings. 

(c) If an issue is to be discussed or otherwise arises at any meeting of the board of directors of the Borrower or committee
thereof which, in the reasonable good faith judgment of the board of directors, is not appropriate to be discussed in the presence of an Observer in order to avoid a conflict of interest on the part of such Observer or to preserve an attorney-client
privilege, then such 

  
 -4- 

 
issue may be discussed without such Observer being present and any materials delivered to the board of directors pertaining to such issue need not be delivered to such Observer, so long as such
Observer is given notice of the occurrence of such judgment by the board of directors, that such Observer is being excused, and that certain materials will not be delivered to such Observer, and such Observer is provided a general description, which
shall be true and correct in all material respects, of such withheld materials and matters discussed without such Observer present. 
 (j)
Section 8.4(b) is hereby amended and restated in its entirety as follows: 
 (b) Minimum Liquidity. The Liquidity
of the Borrower shall not at any time be less than $3,000,000. The Borrower shall maintain an amount equal to the amount required under this Section 8.4(b), along with its other cash and Cash Equivalent Investments, in a Controlled
Account. 
 3. Conditions to Effectiveness of Amendment. This Amendment shall become effective upon receipt by: 

(a) the Lender of a counterpart signature to this Amendment duly executed and delivered by the Borrower and each of the other Credit Obligors,

 (b) the Lender of the amended and restated Note duly executed and delivered by an Authorized Officer of the Borrower, 

(c) the Credit Obligors of a counterpart signature to this Amendment duly executed and delivered by the Lender, 

(d) the Lender of a Secretary’s Certificate with respect to each U.S. Obligor, in substantially the form delivered on the Closing Date,
duly executed and delivered by the signatories thereto and a verification certificate for each of Unilife Medical Solutions Pty Limited and Unitract Syringe Pty Ltd in substantially the form delivered on the Closing Date, in each case attaching
resolutions of each such Person’s Board of Directors (or other managing body, in the case of other than a corporation) then in full force and effect authorizing the execution, delivery and performance of this Amendment and the amended and
restated Note delivered in connection herewith to be executed by such Person and the transactions contemplated hereby and thereby, 
 (e)
the Lender from each U.S. Obligor, a copy of a good standing certificate, dated a date reasonably close to the date hereof from its jurisdiction of formation, for each such Person, 

(f) the Lender of an opinion of counsel to the Borrower and the other Credit Obligors in form and substance reasonably satisfactory to the
Lender, and 
 (g) the Lender or its counsel of reimbursement for all fees and out-of-pocket expenses incurred by the Lender in connection
with this Amendment and all other like expenses remaining unpaid as of the date hereof. 

  
 -5- 

 4. Expenses. The Borrower agrees to pay on demand all expenses of the Lender (including,
without limitation, the fees and out-of-pocket expenses of Covington & Burling LLP, counsel to the Lender, and of local counsel, if any, who may be retained by or on behalf of the Lender) incurred in connection with the negotiation,
preparation, execution and delivery of this Amendment and all other expenses of the Lender remaining unpaid as of the date hereof. 
 5.
Representations and Warranties. The Credit Obligors represent and warrant to the Lender as follows: 
 (a) After giving effect to
this Amendment, the representations and warranties of the Borrower and the Guarantors contained in the Credit Agreement or any other Loan Document (other than Section 6.14 of the Credit Agreement) shall except as disclosed in the disclosure
letter dated the date hereof and delivered to the Lender on the date hereof, (i) with respect to representations and warranties that contain a materiality qualification, be true and correct in all respects on and as of the date hereof, and
(ii) with respect to representations and warranties that do not contain a materiality qualification, be true and correct in all material respects on and as of the date hereof, and except that the representations and warranties limited by their
terms to a specific date shall be true and correct as of such date. 
 (b) After giving effect to this Amendment, no Default or Event of
Default has occurred or is continuing. 
 (c) (i) Each Credit Obligor has taken all necessary action to authorize the execution, delivery
and performance of this Amendment and (with respect to the Borrower) the amended and restated Note; (ii) this Amendment and (with respect to the Borrower) the amended and restated Note has been duly executed and delivered by the Credit Obligors
and constitutes each of the Credit Obligors’ legal, valid and binding obligations, enforceable in accordance with its terms (except, in any case, as such enforceability may be limited by applicable bankruptcy, insolvency, reorganization or
similar laws affecting creditors’ rights generally and by principles of equity), and (iii) no authorization or other action by, and no notice to or filing with, any Governmental Authority or other Person is required for the due execution,
delivery or performance by any Credit Obligor of this Amendment or (with respect to the Borrower) the amended and restated Note. 
 (d) At
the date of this Amendment, none of the Collateral (as defined in the General Security Deed) is located, or taken for the purposes of any stamp duty law to be located, in New South Wales. 

6. No Implied Amendment or Waiver. Except as expressly set forth in this Amendment, this Amendment shall not, by implication or
otherwise, limit, impair, constitute a waiver of or otherwise affect any rights or remedies of the Lender under the Credit Agreement or the other Loan Documents, or alter, modify, amend or in any way affect any of the terms, obligations or covenants
contained in the Credit Agreement or the other Loan Documents, all of which shall continue in full force and effect. Nothing in this Amendment shall be construed to imply any willingness on the part of the Lender to agree to or grant any similar or
future amendment, consent or waiver of any of the terms and conditions of the Credit Agreement or the other Loan Documents. 

  
 -6- 

 7. Reaffirmation of Security Interests. The Credit Obligors (i) affirm that each of
the security interests and liens granted in or pursuant to the Loan Documents are valid and subsisting and (ii) agree that this Amendment and the amended and restated Note shall in no manner impair or otherwise adversely affect any of the
security interests and liens granted in or pursuant to the Loan Documents. 
 8. Reaffirmation of Guarantee. Each Guarantor
(a) acknowledges and consents to all of the terms and conditions of this Amendment and the amended and restated Note, (b) affirms all of its obligations under the Loan Documents and (c) agrees that this Amendment, the amended and
restated Note and all documents executed in connection herewith do not operate to reduce or discharge the Guarantor’s obligations under the Loan Documents. 

9. Press Release. No Credit Obligor shall, and each Credit Obligor shall instruct its Affiliates not to, issue a press release or other
public announcement or otherwise make any public disclosure with respect to this Amendment or the subject matter hereof without the prior consent of the Lender (which consent shall not be unnecessarily withheld or delayed), except as may be required
by applicable Law (in which case the Credit Obligor required to make the release or statement shall allow the Lender reasonable time to comment on such release or statement in advance of such issuance). 

10. Waiver and Release. TO INDUCE THE LENDER TO AGREE TO THE TERMS OF THIS AMENDMENT, EACH CREDIT OBLIGOR REPRESENTS AND WARRANTS THAT
AS OF THE DATE HEREOF THERE ARE NO CLAIMS OR OFFSETS AGAINST OR RIGHTS OF RECOUPMENT WITH RESPECT TO OR DEFENSES OR COUNTERCLAIMS TO ITS OBLIGATIONS UNDER THE LOAN DOCUMENTS AND IN ACCORDANCE THEREWITH IT: 

(a) WAIVES ANY AND ALL SUCH CLAIMS, OFFSETS, RIGHTS OF RECOUPMENT, DEFENSES OR COUNTERCLAIMS, WHETHER KNOWN OR UNKNOWN, ARISING PRIOR TO THE
DATE HEREOF; AND 
 (b) RELEASES AND DISCHARGES THE LENDER, ITS AFFILIATES AND ITS AND THEIR OFFICERS, DIRECTORS, EMPLOYEES, AGENTS,
SHAREHOLDERS AND ATTORNEYS (COLLECTIVELY THE “RELEASED PARTIES”) FROM ANY AND ALL OBLIGATIONS, INDEBTEDNESS, LIABILITIES, CLAIMS, RIGHTS, CAUSES OF ACTION OR DEMANDS WHATSOEVER, WHETHER KNOWN OR UNKNOWN, SUSPECTED OR UNSUSPECTED, IN
LAW OR EQUITY, WHICH THE BORROWER EVER HAD, NOW HAS, CLAIMS TO HAVE OR MAY HAVE AGAINST ANY RELEASED PARTY ARISING PRIOR TO THE DATE HEREOF AND FROM OR IN CONNECTION WITH THE LOAN DOCUMENTS OR THE TRANSACTIONS CONTEMPLATED THEREBY. 

11. Counterparts; Governing Law. This Amendment may be executed in any number of counterparts and by different parties hereto on
separate counterparts, each of such 

  
 -7- 

 
when so executed and delivered shall be an original, but all of such counterparts shall together constitute but one and the same agreement. Delivery of an executed counterpart of a signature page
of this Amendment by fax transmission or other electronic mail transmission (e.g., “pdf” or “tif”) shall be effective as delivery of a manually executed counterpart of this Amendment. THIS AMENDMENT SHALL BE GOVERNED BY, AND
CONSTRUED IN ACCORDANCE WITH, THE INTERNAL LAWS OF THE STATE OF NEW YORK (INCLUDING FOR SUCH PURPOSE SECTIONS 5-1401 AND 5-1402 OF THE GENERAL OBLIGATIONS LAW OF THE STATE OF NEW YORK). 

[Remainder of Page Intentionally Left Blank] 

  
 -8- 

 IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be executed by their
respective officers thereunto duly authorized as of the day and year first above written. 
 EXECUTED as a deed by each Australian Subsidiary. 

 

													
	UNILIFE MEDICAL SOLUTIONS, INC.	 		 	UNILIFE CORPORATION
					
	By:	 	 /s/ John C. Ryan
	 		 	By:	 	 /s/ John C. Ryan

		 	Name:	 	John C. Ryan	 		 		 	Name:	 	John C. Ryan
		 	Title:	 	Senior Vice President, General Counsel and Secretary	 		 		 	Title:	 	Senior Vice President, General Counsel and Secretary
					
		 		 		 		 	UNILIFE CROSS FARM LLC
						
		 		 		 		 	By:	 	 /s/ John C. Ryan

		 		 		 		 		 	Name:	 	John C. Ryan
		 		 		 		 		 	Title:	 	Senior Vice President, General Counsel and Secretary

 Signature Page to Third Amendment to Credit Agreement 

											
	Executed by Unilife Medical Solutions Pty Limited in accordance with Section 127 of the Corporations Act 2001	 		 		 		 	
					
	 /s/ Alan Shortall
	 	f	 		 	 /s/ Ramin Mojdeh
	 	f
	Signature of director	 		 		 	Signature of director	 	
					
	 Alan Shortall
	 		 		 	 Ramin Mojdeh
	 	
	Name of director (print)	 		 		 	Name of director (print)	 	
					
	Executed by Unitract Syringe Pty Ltd in accordance with Section 127 of the Corporations Act 2001	 		 		 		 	
					
	 /s/ Alan Shortall
	 	f	 		 	 /s/ Ramin Mojdeh
	 	f
	Signature of director	 		 		 	Signature of director	 	
					
	 Alan Shortall
	 		 		 	 Ramin Mojdeh
	 	
	Name of director (print)	 		 		 	Name of director (print)	 	

 Signature Page to Third Amendment to Credit Agreement 

 
			
	ROS ACQUISITION OFFSHORE LP,
as the Lender
	By OrbiMed Advisors LLC, its investment manager
		
	By:	 	 /s/ Samuel Isaly

		 	Name: Samuel Isaly
		 	Title:   Managing Member

 Signature Page to Third Amendment to Credit Agreement 

 Disclosure Letter 

Pursuant to the Amendments to the Credit Agreement and Royalty Agreement dated as of October 13, 2015 (the “Amendments”), by and between
Unilife Medical Solutions, Inc., a Delaware corporation (the “Company”) and ROS Acquisition Offshore LP (the “Lender”), the Company hereby provides to the Lender these disclosures (“Disclosures”) to modify the
representations and warranties made and referenced in the Amendments. 
 Inclusion of any item in these Disclosures (i) except to the extent expressly
stated in these Disclosures, does not represent a determination by the Company that such item is “material,” nor shall it be deemed to establish a standard of materiality; (ii) does not represent a determination by the Company that
such item did not arise in the ordinary course of business; and (iii) shall not constitute or be deemed to be an admission to any third party concerning any item set forth herein. 

Except as otherwise limited herein, all information and disclosures made herein are made as of the date hereof. Terms not otherwise defined herein will have
the definitions set forth in the Loan Documents. 
  

	 	•	 	With respect to Section 6.6 of the Credit Agreement, please see the Company’s most recent 10-K filed with the Securities and Exchange Commission on September 14, 2015 and the 8-Ks filed since that date.

  

	 	•	 	With respect to Section 6.19 of the Credit Agreement, please see the Company’s 8-K filed on October 7, 2015 describing a loan from the Company’s CEO. 

 

	 	•	 	With respect to Section 6.7 of the Credit Agreement, please see the litigation and contingency disclosures in the Company’s most recent 10-K filed with the Securities and Exchange Commission on
September 14, 2015. 

  

	 	•	 	The Company is late on the October lease payment for its King of Prussia, Pennsylvania facility and is therefore in default under the lease. The Company expects to use proceeds received in connection with the Amendments
to make the payment along with accrued interest. 

  

	 	•	 	Mechanics liens have been filed on the Company’s York, Pennsylvania premises by a Company contractor at that facility, and subcontractors to that contractor have provided notice of intent to file mechanics liens as
well. The Company expects to pursue fundraising opportunities in order to make payments to both the contractor and subcontractors. Unless and until the Company receives additional funding, further mechanics liens may be filed. 

 

	 	•	 	Unilife received notice from an equipment provider dated October 9, 2015 that the Company is past due on a purchase order and that the nonpayment constitutes a default under the purchase order. The Company expects
to use proceeds received in connection with the Amendments to make payment on the purchase order. 

  

	 	•	 	A supplier filed a complaint against the Company on October 5, 2015 for non-payment of invoices for products provided to Company. The Company has since paid the amount owed. 

 

	 	•	 	The Company is late and in default under a purchase order with one of its suppliers. The Company maintains communications with the supplier and has verbally agreed with the supplier on a payment schedule.

  

	 	•	 	Litigation filed on April 8, 2013 by Biodel, Inc. 

  

	 	•	 	Administrative claim before the Pennsylvania Human Relations Commission filed on September 29, 2015 by a former employee/machine operator. 

	 	•	 	The Company may not have provided copies of Material Agreements within the timeframe set forth in the Credit Agreement. Copies of Material Agreements have been noted and delivered separately to the Lender.

  

	 	•	 	The Company obtained a continued waiver from the Lender of the covenant to maintain a $5.0 million cash balance until October 13, 2015.

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