Document:

EX-4.2

 Exhibit 4.2 

CRINETICS PHARMACEUTICALS, INC. 

AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT 

THIS AMENDED AND RESTATED INVESTOR RIGHTS
AGREEMENT (this “Agreement”) is entered into as of February 9, 2018 by and among CRINETICS PHARMACEUTICALS, INC., a Delaware corporation (the
“Company”), and the investors listed on Exhibit A hereto (collectively referred to hereinafter as the “Investors” and each individually as an
“Investor”). 
 RECITALS 

WHEREAS, the Company and certain of the Investors are party to that certain Investor Rights Agreement, dated as
of October 30, 2015 (the “Prior Agreement”); 
 WHEREAS, certain of the Investors are
purchasing shares of the Company’s Series B Preferred Stock, par value of $0.001 per share (the “Series B Preferred”), pursuant to that certain Series B Preferred Stock Purchase Agreement (as may be amended
from time to time, the “Purchase Agreement”) of even date herewith (the “Financing”); 

WHEREAS, certain of the Investors are holders of the Company’s Series A Preferred
Stock, par value $0.001 per share (the “Series A Preferred”); 

WHEREAS, the obligations in the Purchase Agreement are conditioned upon the execution and
delivery of this Agreement; 
 WHEREAS, in connection with the consummation of the
Financing, the parties desire to enter into this Agreement in order to grant registration, information rights and other rights to the Investors as set forth below; and 

WHEREAS, the parties to the Prior Agreement desire to amend and restate the Prior Agreement and accept the rights and
covenants hereof in lieu of their rights and covenants under the Prior Agreement. 
 NOW, THEREFORE, in
consideration of these premises and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto agree as follows: 

SECTION 1. GENERAL. 

1.1    Definitions. As used in this Agreement the following terms shall have the following respective
meanings: 
 (a)    “Affiliate” means, with respect to any specified Person, any other
Person who, directly or indirectly, controls, is controlled by, or is under common control with such Person, including, without limitation, any general partner, managing member, officer or director of such Person or any venture capital fund now or
hereafter existing that is controlled by one or 

 
more general partners or managing members of, or shares the same management company with, such Person. 

(b)    “Exchange Act” means the Securities Exchange Act of 1934, as amended. 

(c)    “Form S-3” means such form under the
Securities Act as in effect on the date hereof or any successor or similar registration form under the Securities Act subsequently adopted by the SEC which permits inclusion or incorporation of substantial information by reference to other documents
filed by the Company with the SEC. 
 (d)    “Holder” means any person owning of record
Registrable Securities that have not been sold to the public or any assignee of record of such Registrable Securities in accordance with Section 2.9 hereof. 

(e)    “Initial Offering” means the Company’s first firm commitment underwritten
public offering of its Common Stock registered under the Securities Act. 
 (f)    “Major
Investor” means an Investor that, together with its Affiliates, holds Registrable Securities having an aggregate original issue price of not less than $5,000,000. 

(g)    “Person” means any individual, corporation, partnership, trust, limited liability
company, association or other entity. 
 (h)    “Preferred Stock” means the Series A
Preferred and the Series B Preferred. 
 (i)    “Qualified IPO” has the meaning ascribed
to such term in the Restated Charter. 
 (j)    “Register,” “registered,” and
“registration” refer to a registration effected by preparing and filing a registration statement in compliance with the Securities Act, and the declaration or ordering of effectiveness of such registration statement or
document. 
 (k)    “Registrable Securities” means (a) Common Stock of the Company
issuable or issued upon conversion of the Shares, (b) Common Stock, or Common Stock issuable upon the conversion and/or exercise of any other securities of the Company, acquired by Investors and (c) any Common Stock of the Company issued
as (or issuable upon the conversion or exercise of any warrant, right or other security which is issued as) a dividend or other distribution with respect to, or in exchange for or in replacement of, such above-described securities. Notwithstanding
the foregoing, Registrable Securities shall not include any securities (i) sold by a person to the public either pursuant to a registration statement or Rule 144 or (ii) sold in a private transaction in which the transferor’s rights
under Section 2 of this Agreement are not assigned. 
 (l)    “Registrable Securities then
outstanding” and “outstanding Registrable Securities” shall be the number of shares of the Company’s Common Stock that are Registrable Securities and either (a) are then issued and outstanding or
(b) are issuable pursuant to exercisable or convertible securities. 

  
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 (m)    “Registration Expenses” means all
expenses incurred by the Company in complying with Sections 2.2, 2.3 and 2.4 hereof, including, without limitation, all registration and filing fees, printing expenses, fees and disbursements of counsel for the Company, reasonable fees and
disbursements not to exceed $35,000 of a single special counsel for the Holders, blue sky fees and expenses and the expense of any special audits incident to or required by any such registration (but excluding the compensation of regular
employees of the Company which shall be paid in any event by the Company). 
 (n)    “Requisite
Investors” means (i) Investors holding at least a majority of the outstanding shares of Series A Preferred, and (ii) Investors holding at least a majority of the outstanding shares of Series B Preferred, in each case voting as
separate classes on an as-converted to Common Stock basis. 

(o)    “Restated Charter” means the Company’s Amended and Restated Certificate of
Incorporation, as amended from time to time. 
 (p)    “SEC” means the Securities and
Exchange Commission. 
 (q)    “Securities Act” means the Securities Act of 1933, as
amended. 
 (r)    “Selling Expenses” means all underwriting discounts and selling
commissions applicable to the sale. 
 (s)    “Series Preferred Directors” has the
meaning ascribed to such term in the Restated Charter. 
 (t)    “Shares” means the
shares of Preferred Stock held from time to time by the Investors listed on Exhibit A hereto and their permitted assigns. 

(u)    “Special Registration Statement” means (i) a registration statement relating to
any employee benefit plan or (ii) with respect to any corporate reorganization or transaction under Rule 145 of the Securities Act, any registration statements related to the issuance or resale of securities issued in such a transaction or
(iii) a registration related to stock issued upon conversion of debt securities. 

(v)    “Voting Agreement” means that certain Amended and Restated Voting Agreement, dated
of even date herewith and as may be amended from time to time, by and among the Company and those certain holders of Common Stock listed on Exhibit A thereto and the persons and entities listed on Exhibit B thereto. 

SECTION 2. REGISTRATION; RESTRICTIONS ON TRANSFER. 

2.1    Restrictions on Transfer. 

(a)    Each Holder agrees not to make any disposition of all or any portion of the Shares or Registrable Securities
unless and until: 

  
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 (i)    there is then in effect a registration statement under the
Securities Act covering such proposed disposition and such disposition is made in accordance with such registration statement; or 

(ii)    (A) The transferee has agreed in writing to be bound by the terms of this Agreement, (B) such
Holder shall have notified the Company of the proposed disposition and shall have furnished the Company with a detailed statement of the circumstances surrounding the proposed disposition, and (C) if reasonably requested by the Company, such
Holder shall have furnished the Company with an opinion of counsel, reasonably satisfactory to the Company, that such disposition will not require registration of such shares under the Securities Act. It is agreed that the Company will not require
opinions of counsel for transactions made pursuant to Rule 144, except in unusual circumstances. After its Initial Offering, the Company will not require any transferee pursuant to Rule 144 to be bound by the terms of this Agreement if the shares so
transferred do not remain Registrable Securities hereunder following such transfer. 
 (b)    Notwithstanding the
provisions of subsection (b) above, no such restriction shall apply to a transfer by a Holder that is (A) a partnership transferring to its partners or former partners in accordance with partnership interests, (B) a corporation
transferring to a wholly owned subsidiary or a parent corporation that owns all of the capital stock of the Holder, (C) a limited liability company transferring to its members or former members in accordance with their interest in the limited
liability company, or (D) an individual transferring to the Holder’s family member or trust for the benefit of an individual Holder; provided that in each case the transferee will agree in writing to be subject to the terms of this
Agreement to the same extent as if he were an original Holder hereunder. 
 (c)    Each certificate representing
Shares or Registrable Securities shall be stamped or otherwise imprinted with legends substantially similar to the following (in addition to any legend required under applicable state securities laws): 

THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933 (THE “ACT”) AND MAY NOT BE OFFERED, SOLD
OR OTHERWISE TRANSFERRED, ASSIGNED, PLEDGED OR HYPOTHECATED UNLESS AND UNTIL REGISTERED UNDER THE ACT OR UNLESS THE COMPANY HAS RECEIVED AN OPINION OF COUNSEL SATISFACTORY TO THE COMPANY AND ITS COUNSEL THAT SUCH REGISTRATION IS NOT REQUIRED. 

THE SALE, PLEDGE, HYPOTHECATION OR TRANSFER OF THE SECURITIES REPRESENTED BY THIS CERTIFICATE IS SUBJECT TO THE TERMS AND CONDITIONS OF A
CERTAIN INVESTOR RIGHTS AGREEMENT BY AND BETWEEN THE STOCKHOLDER AND THE COMPANY. COPIES OF SUCH AGREEMENT MAY BE OBTAINED UPON 

  
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WRITTEN REQUEST TO THE SECRETARY OF THE COMPANY. 

(d)    The Company shall be obligated to reissue promptly unlegended certificates at the request of any Holder
thereof if the Company has completed its Initial Offering and the Holder shall have obtained an opinion of counsel (which counsel may be counsel to the Company) reasonably acceptable to the Company to the effect that the securities proposed to be
disposed of may lawfully be so disposed of without registration, qualification and legend, provided that the second legend listed above shall be removed only at such time as the Holder of such certificate is no longer subject to any
restrictions hereunder. 
 (e)    Any legend endorsed on an instrument pursuant to applicable state securities
laws and the stop-transfer instructions with respect to such securities shall be removed upon receipt by the Company of an order of the appropriate blue sky authority authorizing such removal. 

2.2    Demand Registration. 

(a)    Subject to the conditions of this Section 2.2, if the Company receives a written request from the
Holders of at least 30% of the Registrable Securities (the “Initiating Holders”) that the Company file a registration statement under the Securities Act covering the registration of at least 20% of the Registrable Securities
held by the Initiating Holders (provided that the anticipated aggregate offering price, net of underwriting discounts and commissions, would exceed $20,000,000 if the request is made prior to the Initial Offering, or $5,000,000 if the request is
made after the Initial Offering), then the Company shall, within 30 days of the receipt thereof, give written notice of such request to all Holders, and subject to the limitations of this Section 2.2, effect, as expeditiously as reasonably
possible within 90 days following such request, the registration under the Securities Act of all Registrable Securities that all Holders request to be registered. 

(b)    If the Initiating Holders intend to distribute the Registrable Securities covered by their request by means
of an underwriting, they shall so advise the Company as a part of their request made pursuant to this Section 2.2 or any request pursuant to Section 2.4 and the Company shall include such information in the written notice referred to in
Section 2.2(a) or Section 2.4(a), as applicable. In such event, the right of any Holder to include its Registrable Securities in such registration shall be conditioned upon such Holder’s participation in such underwriting and the
inclusion of such Holder’s Registrable Securities in the underwriting to the extent provided herein. All Holders proposing to distribute their securities through such underwriting shall enter into an underwriting agreement in customary form
with the underwriter or underwriters selected for such underwriting by the Holders of a majority of the Registrable Securities held by all Initiating Holders (which underwriter or underwriters shall be reasonably acceptable to the Company).
Notwithstanding any other provision of this Section 2.2 or Section 2.4, if the underwriter advises the Company that marketing factors require a limitation of the number of securities to be underwritten (including Registrable Securities)
then the Company shall so advise all Holders of Registrable Securities that would otherwise be underwritten pursuant hereto, and the number of shares that may be included in the underwriting shall be allocated to the Holders of such Registrable
Securities on a pro rata basis based on the number 

  
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of Registrable Securities held by all such Holders (including the Initiating Holders); provided, however, that the number of shares of Registrable Securities to be included in such
underwriting and registration shall not be reduced unless all other securities of the Company are first entirely excluded from the underwriting and registration. Any Registrable Securities excluded or withdrawn from such underwriting shall be
withdrawn from the registration. 
 (c)    The Company shall not be required to effect a registration pursuant to
this Section 2.2: 
 (i)    prior to the earlier of (A) the fifth anniversary of the date of this
Agreement or (B) six months following the effective date of a registration statement under the Securities Act for the Initial Offering; 

(ii)    after the Company has effected two registrations pursuant to this Section 2.2, and such
registrations have been declared or ordered effective; 
 (iii)    during the period starting with the date of
filing of, and ending on the date 180 days following the effective date of the registration statement pertaining to the Initial Offering (or such longer period as may be determined pursuant to Section 2.11 hereof); provided that
the Company makes reasonable good faith efforts to cause such registration statement to become effective; 

(iv)    if within 30 days of receipt of a written request from Initiating Holders pursuant to Section 2.2(a),
the Company gives notice to the Holders of the Company’s intention to file a registration statement within 90 days for an anticipated Qualified IPO; 

(v)    if the Company furnishes to Holders requesting a registration statement pursuant to this Section 2.2 a
certificate signed by the Chairman of the Company’s Board of Directors (the “Board”) stating that in the good faith judgment of the Board it would be seriously detrimental to the Company and its stockholders for such
registration statement to be effected at such time, in which event the Company shall have the right to defer such filing for a period of not more than 100 days after receipt of the request of the Initiating Holders; provided that such right
to delay a request shall be exercised by the Company not more than twice in any 12 month period; 
 (vi)    if
the Initiating Holders propose to dispose of shares of Registrable Securities that may be immediately registered on Form S-3 pursuant to a request made pursuant to Section 2.4 below; or 

(vii)    in any particular jurisdiction in which the Company would be required to qualify to do business or to
execute a general consent to service of process in effecting such registration, qualification or compliance. 

2.3    Piggyback Registrations. The Company shall notify all Holders of Registrable Securities in writing at
least 20 days prior to the filing of any registration statement under the Securities Act for purposes of a public offering of securities of the Company (including, but not limited to, registration statements relating to secondary offerings of
securities of the Company, but excluding Special Registration Statements) and will afford each such Holder an opportunity 

  
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to include in such registration statement all or part of such Registrable Securities held by such Holder. Each Holder desiring to include in any such registration statement all or any part of the
Registrable Securities held by it shall, within 20 days after the above-described notice from the Company, so notify the Company in writing. Such notice shall state the intended method of disposition of the Registrable Securities by such Holder. If
a Holder decides not to include all of its Registrable Securities in any registration statement thereafter filed by the Company, such Holder shall nevertheless continue to have the right to include any Registrable Securities in any subsequent
registration statement or registration statements as may be filed by the Company with respect to offerings of its securities, all upon the terms and conditions set forth herein. 

(a)    Underwriting. If the registration statement of which the Company gives notice under this
Section 2.3 is for an underwritten offering, the Company shall so advise the Holders of Registrable Securities. In such event, the right of any such Holder to include Registrable Securities in a registration pursuant to this Section 2.3
shall be conditioned upon such Holder’s participation in such underwriting and the inclusion of such Holder’s Registrable Securities in the underwriting to the extent provided herein. All Holders proposing to distribute their Registrable
Securities through such underwriting shall enter into an underwriting agreement in customary form with the underwriter or underwriters selected for such underwriting by the Company. Notwithstanding any other provision of this Agreement, if the
Company determines in good faith, based on consultation with the underwriter, that marketing factors require a limitation of the number of shares to be underwritten, the number of shares that may be included in the underwriting shall be allocated,
first, to the Company; second, to the Holders on a pro rata basis based on the total number of Registrable Securities held by the Holders; and third, to any stockholder of the Company (other than a Holder) on a pro rata basis;
provided, however, that no such reduction shall reduce the amount of securities of the selling Holders included in the registration below 25% of the total amount of securities included in such registration, unless such offering is a Qualified IPO
and such registration does not include shares of any other selling stockholders, in which event any or all of the Registrable Securities of the Holders may be excluded in accordance with the immediately preceding clause. In no event will shares of
any other selling stockholder be included in such registration that would reduce the number of shares which may be included by Holders without the written consent of Holders of not less than a majority of the Registrable Securities proposed to be
sold in the offering. If any Holder disapproves of the terms of any such underwriting, such Holder may elect to withdraw therefrom by written notice to the Company and the underwriter, delivered by the later of (i) 10 business days prior to the
effective date of the registration statement and (ii) five business days after the Holder is furnished with the final terms of such underwriting. Any Registrable Securities excluded or withdrawn from such underwriting shall be excluded and
withdrawn from the registration. For any Holder which is a partnership, limited liability company or corporation, the partners, retired partners, members, retired members and stockholders of such Holder, or the estates and family members of any such
partners, retired partners, members and retired members and any trusts for the benefit of any of the foregoing person shall be deemed to be a single “Holder,” and any pro rata reduction with respect to such “Holder” shall
be based upon the aggregate amount of shares carrying registration rights owned by all entities and individuals included in such “Holder,” as defined in this sentence. 

(b)    Right to Terminate Registration. The Company shall have the right to terminate or withdraw any
registration initiated by it under this Section 2.3 whether or not any 

  
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Holder has elected to include securities in such registration, and shall promptly notify any Holder that has elected to include shares in such registration of such termination or withdrawal. The
Registration Expenses of such withdrawn registration shall be borne by the Company in accordance with Section 2.5 hereof. 

2.4    Form S-3 Registration. In case the Company shall receive from
any Holder or Holders of Registrable Securities a written request or requests that the Company effect a registration on Form S-3 (or any successor to Form S-3)
or any similar short-form registration statement and any related qualification or compliance with respect to all or a part of the Registrable Securities owned by such Holder or Holders, the Company will: 

(a)    promptly give written notice of the proposed registration, and any related qualification or compliance, to
all other Holders of Registrable Securities; and 
 (b)    as soon as practicable, effect such registration and
all such qualifications and compliances as may be so requested and as would permit or facilitate the sale and distribution of all or such portion of such Holder’s or Holders’ Registrable Securities as are specified in such request,
together with all or such portion of the Registrable Securities of any other Holder or Holders joining in such request as are specified in a written request given within 15 days after receipt of such written notice from the Company; provided,
however, that the Company shall not be obligated to effect any such registration, qualification or compliance pursuant to this Section 2.4: 

(i)    if Form S-3 is not available for such offering by the Holders;
or 
 (ii)    if the Holders, together with the holders of any other securities of the Company entitled to
inclusion in such registration, propose to sell Registrable Securities and such other securities (if any) at an aggregate price to the public of less than $2,000,000; or 

(iii)    if within 30 days of receipt of a written request from any Holder or Holders pursuant to this
Section 2.4, the Company gives notice to such Holder or Holders of the Company’s intention to make a public offering within 60 days, other than pursuant to a Special Registration Statement; 

(iv)    if the Company furnishes to the Holders a certificate signed by the Chairman of the Board stating that in
the good faith judgment of the Board, it would be seriously detrimental to the Company and its stockholders for such Form S-3 registration to be effected at such time, in which event the Company shall
have the right to defer the filing of the Form S-3 registration statement for a period of not more than 100 days after receipt of the request of the Holder or Holders under this Section 2.4;
provided, that such right to delay a request shall be exercised by the Company not more than twice in any 12 month period; or 

(v)    if the Company has, within the 12 month period preceding the date of such request, already effected two
registrations on Form S-3 for the Holders pursuant to this Section 2.4; or 

  
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 (vi)    in any particular jurisdiction in which the Company would be
required to qualify to do business or to execute a general consent to service of process in effecting such registration, qualification or compliance. 

(c)    Subject to the foregoing, the Company shall file a Form S-3
registration statement covering the Registrable Securities and other securities so requested to be registered as soon as practicable after receipt of the requests of the Holders. Registrations effected pursuant to this Section 2.4 shall not be
counted as demands for registration or registrations effected pursuant to Section 2.2. 
 2.5    Expenses
of Registration. Except as specifically provided herein, all Registration Expenses incurred in connection with any registration, qualification or compliance pursuant to Section 2.2, 2.3 or 2.4 herein shall be borne by the Company. All
Selling Expenses incurred in connection with any registrations hereunder, shall be borne by the holders of the securities so registered pro rata on the basis of the number of shares so registered. The Company shall not, however, be required
to pay for expenses of any registration proceeding begun pursuant to Section 2.2 or 2.4, the request of which has been subsequently withdrawn by the Initiating Holders unless (a) the withdrawal is based upon material adverse information
concerning the Company of which the Initiating Holders were not aware at the time of such request or (b) the Holders of a majority of Registrable Securities agree to deem such registration to have been effected as of the date of such withdrawal
for purposes of determining whether the Company shall be obligated pursuant to Section 2.2(c) or 2.4(b)(v), as applicable, to undertake any subsequent registration, in which event such right shall be forfeited by all Holders). If the Holders
are required to pay the Registration Expenses, such expenses shall be borne by the holders of securities (including Registrable Securities) requesting such registration in proportion to the number of shares for which registration was requested. If
the Company is required to pay the Registration Expenses of a withdrawn offering pursuant to clause (a) above, then such registration shall not be deemed to have been effected for purposes of determining whether the Company shall be obligated
pursuant to Section 2.2(c) or 2.4(b)(v), as applicable, to undertake any subsequent registration. 

2.6    Obligations of the Company. Whenever required to effect the registration of any Registrable
Securities, the Company shall, as expeditiously as reasonably possible: 
 (a)    prepare and file with the SEC a
registration statement with respect to such Registrable Securities and use all reasonable efforts to cause such registration statement to become effective, and, upon the request of the Holders of a majority of the Registrable Securities registered
thereunder, keep such registration statement effective for 120 days or, if earlier, until the Holder or Holders have completed the distribution related thereto; provided, however, that at any time, upon written notice to the participating Holders
and for a period not to exceed 60) days thereafter (the “Suspension Period”), the Company may delay the filing or effectiveness of any registration statement or suspend the use or effectiveness of any registration statement
(and the Initiating Holders hereby agree not to offer or sell any Registrable Securities pursuant to such registration statement during the Suspension Period) if the Company reasonably believes that there is or may be in existence material nonpublic
information or events involving the Company, the failure of which to be disclosed in the prospectus included in the registration statement could result in a Violation (as defined below). In the event that the Company shall exercise its right to

  
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delay or suspend the filing or effectiveness of a registration hereunder, the applicable time period during which the registration statement is to remain effective shall be extended by a period
of time equal to the duration of the Suspension Period. The Company may extend the Suspension Period for an additional consecutive 60 days with the consent of the holders of at least a majority of the Registrable Securities registered under the
applicable registration statement, which consent shall not be unreasonably withheld. No more than two such Suspension Periods shall occur in any 12 month period. In no event shall any Suspension Period, when taken together with all prior Suspension
Periods, exceed 120 days in the aggregate. If so directed by the Company, all Holders registering shares under such registration statement shall (i) not offer to sell any Registrable Securities pursuant to the registration statement during the
period in which the delay or suspension is in effect after receiving notice of such delay or suspension; and (ii) use their best efforts to deliver to the Company (at the Company’s expense) all copies, other than permanent file copies then
in such Holders’ possession, of the prospectus relating to such Registrable Securities current at the time of receipt of such notice. Notwithstanding the foregoing, the Company shall not be required to file, cause to become effective or
maintain the effectiveness of any registration statement other than a registration statement on Form S-3 that contemplates a distribution of securities on a delayed or continuous basis pursuant to
Rule 415 under the Securities Act. 
 (b)    Prepare and file with the SEC such amendments and supplements
to such registration statement and the prospectus used in connection with such registration statement as may be necessary to comply with the provisions of the Securities Act with respect to the disposition of all securities covered by such
registration statement for the period set forth in subsection (a) above. 
 (c)    Furnish to the Holders
such number of copies of a prospectus, including a preliminary prospectus, in conformity with the requirements of the Securities Act, and such other documents as they may reasonably request in order to facilitate the disposition of Registrable
Securities owned by them. 
 (d)    Use its reasonable efforts to register and qualify the securities covered by
such registration statement under such other securities or Blue Sky laws of such jurisdictions as shall be reasonably requested by the Holders; provided that the Company shall not be required in connection therewith or as a condition thereto
to qualify to do business or to file a general consent to service of process in any such states or jurisdictions. 

(e)    In the event of any underwritten public offering, enter into and perform its obligations under an
underwriting agreement, in usual and customary form, with the managing underwriter(s) of such offering. Each Holder participating in such underwriting shall also enter into and perform its obligations under such an agreement. 

(f)    Notify each Holder of Registrable Securities covered by such registration statement at any time when a
prospectus relating thereto is required to be delivered under the Securities Act of the happening of any event as a result of which the prospectus included in such registration statement, as then in effect, includes an untrue statement of a material
fact or omits to state a material fact required to be stated therein or necessary to make the statements therein not misleading in the light of the circumstances then existing. The Company will amend or

  
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supplement such prospectus in order to cause such prospectus not to include any untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary to
make the statements therein not misleading in the light of the circumstances then existing. 
 (g)    Use its
reasonable efforts to furnish, on the date that such Registrable Securities are delivered to the underwriters for sale, if such securities are being sold through underwriters, (i) an opinion, dated as of such date, of the counsel representing
the Company for the purposes of such registration, in form and substance as is customarily given to underwriters in an underwritten public offering, addressed to the underwriters, if any, and (ii) a letter, dated as of such date, from the
independent certified public accountants of the Company, in form and substance as is customarily given by independent certified public accountants to underwriters in an underwritten public offering addressed to the underwriters. 

2.7    Delay of Registration; Furnishing Information. 

(a)    No Holder shall have any right to obtain or seek an injunction restraining or otherwise delaying any such
registration as the result of any controversy that might arise with respect to the interpretation or implementation of this Section 2. 

(b)    It shall be a condition precedent to the obligations of the Company to take any action pursuant to
Sections 2.2, 2.3 or 2.4 that the selling Holders shall furnish to the Company such information regarding themselves, the Registrable Securities held by them and the intended method of disposition of such securities as shall be required to
effect the registration of their Registrable Securities. 
 (c)    The Company shall have no obligation with
respect to any registration requested pursuant to Section 2.2 or Section 2.4 if the number of shares or the anticipated aggregate offering price of the Registrable Securities to be included in the registration does not equal or exceed the
number of shares or the anticipated aggregate offering price required to originally trigger the Company’s obligation to initiate such registration as specified in Section 2.2 or Section 2.4, whichever is applicable. 

2.8    Indemnification. In the event any Registrable Securities are included in a registration statement
under Sections 2.2, 2.3 or 2.4: 
 (a)    To the extent permitted by law, the Company will indemnify and
hold harmless each Holder, the partners, members, officers and directors of each Holder, any underwriter (as defined in the Securities Act) for such Holder and each person, if any, who controls such Holder or underwriter within the meaning of the
Securities Act or the Exchange Act, against any losses, claims, damages, or liabilities (joint or several) to which they may become subject under the Securities Act, the Exchange Act or other federal or state law, insofar as such losses, claims,
damages or liabilities (or actions in respect thereof) arise out of or are based upon any of the following statements, omissions or violations (collectively a “Violation”) by the Company: (i) any untrue statement or
alleged untrue statement of a material fact contained in such registration statement or incorporated reference therein, including any preliminary prospectus or final prospectus contained therein or any amendments or supplements thereto,

  
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(ii) the omission or alleged omission to state therein a material fact required to be stated therein, or necessary to make the statements therein not misleading, or (iii) any violation
or alleged violation by the Company of the Securities Act, the Exchange Act, any state securities law or any rule or regulation promulgated under the Securities Act, the Exchange Act or any state securities law in connection with the offering
covered by such registration statement; and the Company will reimburse each such Holder, partner, member, officer, director, underwriter or controlling person for any legal or other expenses reasonably incurred by them in connection with
investigating or defending any such loss, claim, damage, liability or action; provided however, that the indemnity agreement contained in this Section 2.8(a) shall not apply to amounts paid in settlement of any such loss, claim, damage,
liability or action if such settlement is effected without the consent of the Company, which consent shall not be unreasonably withheld, nor shall the Company be liable in any such case for any such loss, claim, damage, liability or action to the
extent that it arises out of or is based upon a Violation which occurs in reliance upon and in conformity with written information furnished expressly for use in connection with such registration by such Holder, partner, member, officer, director,
underwriter or controlling person of such Holder. 
 (b)    To the extent permitted by law, each Holder will, if
Registrable Securities held by such Holder are included in the securities as to which such registration qualifications or compliance is being effected, indemnify and hold harmless the Company, each of its directors, its officers and each person, if
any, who controls the Company within the meaning of the Securities Act, any underwriter and any other Holder selling securities under such registration statement or any of such other Holder’s partners, directors or officers or any person who
controls such Holder, against any losses, claims, damages or liabilities (joint or several) to which the Company or any such director, officer, controlling person, underwriter or other such Holder, or partner, director, officer or controlling person
of such other Holder may become subject under the Securities Act, the Exchange Act or other federal or state law, insofar as such losses, claims, damages or liabilities (or actions in respect thereto) arise out of or are based upon any of the
following statements: (i) any untrue statement or alleged untrue statement of a material fact contained in such registration statement or incorporated reference therein, including any preliminary prospectus or final prospectus contained therein
or any amendments or supplements thereto, (ii) the omission or alleged omission to state therein a material fact required to be stated therein, or necessary to make the statements therein not misleading, or (iii) any violation or alleged
violation by the Company of the Securities Act (collectively, a “Holder Violation”), in each case to the extent (and only to the extent) that such Holder Violation occurs in reliance upon and in conformity with written
information furnished by such Holder under an instrument duly executed by such Holder and stated to be specifically for use in connection with such registration; and each such Holder will reimburse any legal or other expenses reasonably incurred by
the Company or any such director, officer, controlling person, underwriter or other Holder, or partner, officer, director or controlling person of such other Holder in connection with investigating or defending any such loss, claim, damage,
liability or action if it is judicially determined that there was such a Holder Violation; provided, however, that the indemnity agreement contained in this Section 2.8(b) shall not apply to amounts paid in settlement of any such loss,
claim, damage, liability or action if such settlement is effected without the consent of the Holder, which consent shall not be unreasonably withheld; provided further, that in no event shall any indemnity under this Section 2.8 exceed
the net proceeds from the offering received by such Holder. 

  
 12 

 (c)    Promptly after receipt by an indemnified party under this
Section 2.8 of notice of the commencement of any action (including any governmental action), such indemnified party will, if a claim in respect thereof is to be made against any indemnifying party under this Section 2.8, deliver to the
indemnifying party a written notice of the commencement thereof and the indemnifying party shall have the right to participate in, and, to the extent the indemnifying party so desires, jointly with any other indemnifying party similarly noticed, to
assume the defense thereof with counsel mutually satisfactory to the parties; provided, however, that an indemnified party shall have the right to retain its own counsel, with the fees and expenses thereof to be paid by the indemnifying
party, if representation of such indemnified party by the counsel retained by the indemnifying party would be inappropriate due to actual or potential differing interests between such indemnified party and any other party represented by such counsel
in such proceeding. The failure to deliver written notice to the indemnifying party within a reasonable time of the commencement of any such action shall relieve such indemnifying party of any liability to the indemnified party under this
Section 2.8 to the extent, and only to the extent, prejudicial to its ability to defend such action, but the omission so to deliver written notice to the indemnifying party will not relieve it of any liability that it may have to any
indemnified party otherwise than under this Section 2.8. 
 (d)    If the indemnification provided for in
this Section 2.8 is held by a court of competent jurisdiction to be unavailable to an indemnified party with respect to any losses, claims, damages or liabilities referred to herein, the indemnifying party, in lieu of indemnifying such
indemnified party thereunder, shall to the extent permitted by applicable law contribute to the amount paid or payable by such indemnified party as a result of such loss, claim, damage or liability in such proportion as is appropriate to reflect the
relative fault of the indemnifying party on the one hand and of the indemnified party on the other in connection with the Violation(s) or Holder Violation(s) that resulted in such loss, claim, damage or liability, as well as any other relevant
equitable considerations. The relative fault of the indemnifying party and of the indemnified party shall be determined by a court of law by reference to, among other things, whether the untrue or alleged untrue statement of a material fact or the
omission to state a material fact relates to information supplied by the indemnifying party or by the indemnified party and the parties’ relative intent, knowledge, access to information and opportunity to correct or prevent such statement or
omission; provided, that in no event shall any contribution by a Holder hereunder exceed the net proceeds from the offering received by such Holder. 

(e)    The obligations of the Company and Holders under this Section 2.8 shall survive completion of any
offering of Registrable Securities in a registration statement and, with respect to liability arising from an offering to which this Section 2.8 would apply that is covered by a registration filed before termination of this Agreement, such
termination. No indemnifying party, in the defense of any such claim or litigation, shall, except with the consent of each indemnified party, consent to entry of any judgment or enter into any settlement which does not include as an unconditional
term thereof the giving by the claimant or plaintiff to such Indemnified Party of a release from all liability in respect to such claim or litigation. 

2.9    Assignment of Registration Rights. The rights to cause the Company to register Registrable Securities
pursuant to this Section 2 may be assigned by a Holder to a transferee or assignee of Registrable Securities (for so long as such shares remain Registrable Securities) that (a) is a subsidiary, parent, general partner, limited partner,
retired partner, member or retired 

  
 13 

 
member, or stockholder of a Holder that is a corporation, partnership or limited liability company, (b) is a Holder’s family member or trust for the benefit of an individual Holder, or
(c) acquires at least 20% of the shares of Registrable Securities originally issued to such Holder; or (d) is an Affiliate of such Holder; provided, however, (i) the transferor shall, within 10 days after such transfer, furnish
to the Company written notice of the name and address of such transferee or assignee and the securities with respect to which such registration rights are being assigned and (ii) such transferee shall agree to be subject to all restrictions set
forth in this Agreement. 
 2.10    Limitation on Subsequent Registration Rights. Other than as provided
in Section 6.10, after the date of this Agreement, the Company shall not enter into any agreement with any holder or prospective holder of any securities of the Company that would grant such holder rights to demand the registration of shares of
the Company’s capital stock, or to include such shares in a registration statement that would reduce the number of shares includable by the Holders. 

2.11    Market Stand-Off Agreement. Each Holder hereby agrees
that such Holder shall not sell, dispose of, transfer, make any short sale of, grant any option for the purchase of, or enter into any hedging or similar transaction with the same economic effect as a sale, any shares of Common Stock (or other
securities) of the Company held by such Holder (other than those included in the registration) during the 180-day period following the effective date of the Initial Offering (or such longer period as the
underwriters or the Company shall request in order to facilitate compliance with FINRA Rule 2711(f)(4) or NYSE Member Rule 472(f)(4) or any successor or similar rule or regulation); provided, that all officers and directors of the Company and
holders of at least 1% of the Company’s voting securities are bound by and have entered into similar agreements.    The foregoing provisions of this Section 2.11 shall apply only to the Initial Offering and shall not
apply to the sale of any shares to an underwriter pursuant to an underwriting agreement. Any discretionary waiver or termination of the restrictions of any or all of such agreements by the Company or the underwriters shall apply pro rata to all
Holders subject to such agreements, based on the number of shares subject to such agreements. 

2.12    Agreement to Furnish Information. Each Holder agrees to execute and deliver such other agreements as
may be reasonably requested by the Company or the managing underwriters that are consistent with the Holder’s obligations under Section 2.11 or that are necessary to give further effect thereto. In addition, if requested by the Company or
the representative of the underwriters of Common Stock (or other securities) of the Company, each Holder shall provide, within 10 days of such request, such information as may be required by the Company or such representative in connection with the
completion of any public offering of the Company’s securities pursuant to a registration statement filed under the Securities Act. The obligations described in Section 2.11 and this Section 2.12 shall not apply to a Special
Registration Statement. In order to enforce the foregoing covenant, the Company may impose stop-transfer instructions with respect to such shares of Common Stock (or other securities) until the end of such period. Each Holder agrees that any
transferee of any shares of Registrable Securities shall be bound by Sections 2.11 and 2.12. The underwriters of the Company’s stock are intended third party beneficiaries of Sections 2.11 and 2.12 and shall have the right, power and
authority to enforce the provisions hereof as though they were a party hereto. 

  
 14 

 2.13    Rule 144 Reporting. With a view to making available to
the Holders the benefits of certain rules and regulations of the SEC which may permit the sale of the Registrable Securities to the public without registration, the Company agrees to use its best efforts to: 

(a)    make and keep public information available, as those terms are understood and defined in SEC Rule 144
or any similar or analogous rule promulgated under the Securities Act, at all times after the effective date of the first registration filed by the Company for an offering of its securities to the general public; 

(b)    file with the SEC, in a timely manner, all reports and other documents required of the Company under the
Exchange Act; and 
 (c)    so long as a Holder owns any Registrable Securities, furnish to such Holder forthwith
upon request: a written statement by the Company as to its compliance with the reporting requirements of said Rule 144 of the Securities Act, and of the Exchange Act (at any time after it has become subject to such reporting requirements); a copy of
the most recent annual or quarterly report of the Company filed with the SEC; and such other reports and documents as a Holder may reasonably request in connection with availing itself of any rule or regulation of the SEC allowing it to sell any
such securities without registration. 
 2.14    Termination of Registration Rights. The right of any
Holder to request registration or inclusion of Registrable Securities in any registration pursuant to Section 2.2, Section 2.3, or Section 2.4 hereof shall terminate upon the earlier of: (i) the third anniversary of a Qualified
IPO or (ii) the closing of an Acquisition (as defined in the Restated Charter). Upon such termination, such shares shall cease to be “Registrable Securities” hereunder for all purposes. 

SECTION 3. COVENANTS OF THE COMPANY. 

3.1    Basic Financial Information and Reporting. 

(a)    The Company will maintain true books and records of account in which full and correct entries will be made
of all its business transactions pursuant to a system of accounting established and administered in accordance with generally accepted accounting principles consistently applied (except as noted therein), and will set aside on its books all such
proper accruals and reserves as shall be required under generally accepted accounting principles consistently applied. 

(b)    As soon as practicable after the end of each fiscal year of the Company, and in any event within 120 days
thereafter, the Company will furnish each Major Investor a balance sheet of the Company, as at the end of such fiscal year, and a statement of income and a statement of cash flows of the Company, for such year, all prepared in accordance with
generally accepted accounting principles consistently applied (except as noted therein) and setting forth in each case in comparative form the figures for the previous fiscal year, all in reasonable detail. Such financial statements shall be
accompanied by a report and opinion thereon by independent public accountants selected by the Board. 

  
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 (c)    The Company will furnish each Major Investor, as soon as
practicable after the end of the first, second and third quarterly accounting periods in each fiscal year of the Company, and in any event within 45 days thereafter, a balance sheet of the Company as of the end of each such quarterly period,
and a statement of income and a statement of cash flows of the Company for such period and for the current fiscal year to date, prepared in accordance with generally accepted accounting principles consistently applied (except as noted
therein), with the exception that no notes need be attached to such statements and year-end audit adjustments may not have been made. 

(d)    The Company will furnish each Major Investor: (i) at least 30 days prior to the beginning of each
fiscal year an annual budget and operating plans for such fiscal year (and as soon as available, any subsequent written revisions thereto); (ii) as soon as practicable after the end of each month, and in any event within 30 days thereafter, a
balance sheet of the Company as of the end of each such month, and a statement of income and a statement of cash flows of the Company for such month and for the current fiscal year to date, prepared in accordance with generally accepted accounting
principles consistently applied (except as noted thereon), with the exception that no notes need be attached to such statements and year-end audit adjustments may not have been made; and (iii) within 30
days after the end of each fiscal year, a statement showing: the number of shares of each class and series of capital stock of the Company and securities convertible into or exercisable for shares of capital stock of the Company outstanding at the
end of such fiscal year and held by each holder; the Common Stock issuable upon conversion or exercise of any outstanding securities convertible or exercisable for Common Stock and the exchange ratio or exercise price applicable thereto; and the
number of shares underlying issued stock options held by each holder and stock options not yet issued but reserved for issuance, if any, all in sufficient detail as to permit the Major Investors to calculate their respective percentage equity
ownership in the Company, and certified by the chief financial officer or chief executive officer of the Company as being true, complete, and correct. 

3.2    Inspection Rights. Each Major Investor shall have the right to visit and inspect any of the
properties of the Company or any of its subsidiaries, and to discuss the affairs, finances and accounts of the Company or any of its subsidiaries with its officers, and to review such information as is reasonably requested all at such reasonable
times and as often as may be reasonably requested; provided, however, that the Company shall not be obligated under this Section 3.2 with respect to a competitor of the Company or with respect to information which the Board determines in
good faith is confidential or attorney-client privileged and should not, therefore, be disclosed. 

3.3    Confidentiality. Each Investor agrees to, and will cause any representative of the Investor to, use
the same degree of care as such Investor uses to protect its own confidential information to keep confidential any information furnished to such Investor or its representatives pursuant to the terms of this Agreement (so long as such information is
not in the public domain), except that such Investor may disclose such proprietary or confidential information (i) to any partner, subsidiary, parent or other Affiliate of such Investor as long as such partner, subsidiary, parent or other
Affiliate is advised of and agrees or has agreed to be bound by the confidentiality provisions of this Section 3.3 or comparable restrictions; (ii) at such time as it enters the public domain through no fault of such Investor;
(iii) that is communicated to it free of any obligation of confidentiality; (iv) that is developed by Investor or its agents independently of 

  
 16 

 
and without reference to any confidential information communicated by the Company; or (v) as required by applicable law. 

3.4    Reservation of Common Stock. The Company will at all times reserve and keep available, solely for
issuance and delivery upon the conversion of the Preferred Stock, all Common Stock issuable from time to time upon such conversion. 

3.5    Stock Vesting. Unless otherwise approved by the Board (including at least a majority of the Series
Preferred Directors), all stock, stock options and other stock equivalents initially issued to new employees, directors, consultants and other service providers after the date of this Agreement shall be subject to vesting as follows: (a) 25% of such
stock shall vest at the end of the first year following the vesting commencement date (which, in the case of new employees or other service providers, shall be the date on which such individual commenced employment with, or providing services for,
the Company, and in all other cases shall be the date of grant), and (b) 75% of such stock shall vest on an equal monthly basis over the following three years. Unless otherwise approved by the Board (including at least a majority of the Series
Preferred Directors), all stock, stock options and other stock equivalents issued to continuing employees, directors, consultants and other service providers after the date of this Agreement shall be subject to vesting as follows: 1/48th of such stock shall vest on a monthly basis over a period of four years. The Company shall have the right to repurchase all such unvested shares at the lower of cost or fair market value upon
termination or resignation of any such employee, director, consultant or other service provider, which repurchase right shall be exercisable for a period of not less than 90 days following such termination or resignation. The employee, director,
consultant or other service provider issued such stock, stock options or other stock equivalents shall not be permitted to transfer such shares prior to their vesting, except for transfers in connection with estate planning purposes that would
otherwise be exempted from the Company’s right of first refusal in the Company’s Bylaws. In addition, unless otherwise approved by the Board (including at least a majority of the Series Preferred Directors), the Company shall retain a
“right of first refusal” on employee transfers until the occurrence of a Qualified IPO, except for transfers exempted from such right of first refusal pursuant to the Company’s Bylaws or pursuant to the
Co-Sale Agreement (as defined in the Purchase Agreement). 
 3.6    
Director and Officer Insurance. The Company shall obtain and maintain in full force and effect director and officer liability insurance in the amount determined by the Board. The Company shall ensure that any agreement or
transaction involving the Company that is expected to result in an Acquisition (as defined in the Restated Charter), in which the Company will not be the surviving entity, will include provisions requiring the successor entity to assume the
Company’s obligations with respect to the indemnification of its directors (which obligations shall survive for a period of not less than six years following the closing of the Acquisition). 

3.7    Observation Rights. The Company shall allow one representative designated by each Major Investor to
attend all meetings of the Board and committees thereof in a nonvoting capacity, and in connection therewith, the Company shall give such representative copies of all notices, minutes, consents and other materials, financial or otherwise, which the
Company provides to the Board or the applicable committee; provided, however, that the Company reserves the right to exclude such representative from access to any material or meeting or 

  
 17 

 
portion thereof if the Company believes upon advice of counsel that such exclusion is reasonably necessary to preserve the attorney-client privilege. The Company will promptly reimburse all
reasonable and actual documented costs and expenses, consistent with any applicable travel policies of the Company in effect from time to time and approved by the Board (including at least a majority of the Series Preferred Directors), incurred by
any such representative in connection with attending all such Board and committee meetings. The rights set forth in this Section 3.7 shall terminate on the date on which an Investor is no longer a Major Investor. 

3.8    Proprietary Information and Inventions Agreement. The Company shall require all employees and
consultants to execute and deliver a Proprietary Information and Inventions Agreement substantially in a form approved by the Company’s counsel or Board. 

3.9     Directors’ Liability and Indemnification. The Company’s Certificate
of Incorporation and Bylaws shall provide (a) for elimination of the liability of director to the maximum extent permitted by law and (b) for indemnification of directors for acts on behalf of the Company to the maximum extent permitted by
law. In addition, the Company shall enter into and use its best efforts to at all times maintain indemnification agreements, in a form reasonably acceptable to the Series Preferred Directors, with each of its directors to indemnify such directors to
the maximum extent permissible under applicable law. 
 3.10    Board Committees. Each committee of the
Board shall include at least one Series Preferred Director, unless otherwise agreed by all of the Investors that have a right to designate a Series Preferred Director pursuant to the Voting Agreement. 

3.11    Board Meetings; Reimbursement of Expenses. The Company shall hold a minimum of one meeting per
calendar quarter, unless otherwise agreed by a majority of all directors of the Company (including a majority of the Series Preferred Directors). The Company will promptly reimburse all reasonable documented costs and expenses, consistent with any
travel policies of the Company in effect from time to time and approved by the Board (including at least a majority of the Series Preferred Directors), incurred by any Series Preferred Director in connection with attending Board meetings, attending
any Board committee meetings, and performing the Company’s business at the request of the Company. 

3.12    Approval. The Company shall not without the approval of a majority of the Board (including at least
a majority of the Series Preferred Directors) authorize or enter into any transactions with any director or officer of the Company, or any member of such director’s or officer’s immediate family. 

3.13    FCPA. The Company covenants that it shall not (and shall not permit any of its subsidiaries or
Affiliates or any of its or their respective directors, officers, managers, employees, independent contractors, representatives or agents to) promise, authorize or make any payment to, or otherwise contribute any item of value to, directly or
indirectly, to any third party, including any Non-U.S. Official (as (as such term is defined in the U.S. Foreign Corrupt Practices Act of 1977, as amended (the “FCPA”)), in each case,
in violation of the FCPA, the U.K. Bribery Act, or any other applicable anti-bribery or anti-corruption law. The Company further covenants that it shall (and shall cause each of its subsidiaries and Affiliates to) cease all of its or their
respective activities, as well as remediate any actions taken by the Company, its 

  
 18 

 
subsidiaries or affiliates, or any of their respective directors, officers, managers, employees, independent contractors, representatives or agents in violation of the FCPA, the U.K. Bribery Act,
or any other applicable anti-bribery or anti-corruption law. Upon request, the Company agrees to provide responsive information and/or certifications concerning its compliance with applicable anti-corruption laws. The Company shall
promptly notify each Investor if the Company becomes aware of any enforcement action pursuant to such laws. The Company shall, and shall cause any direct or indirect subsidiary or entity controlled by it, whether now in existence or formed in
the future, to comply with the FCPA. The Company shall use its best efforts to cause any direct or indirect subsidiary, whether now in existence or formed in the future, to comply in all material respects with all applicable laws. 

3.14    Investor Right to Conduct Activities. To the extent permitted by law, the Company renounces any
interest or expectancy of the Company in, or in being offered an opportunity to participate in, any Specified Opportunity (as defined below). Furthermore, no Fund (as defined below) shall be liable to the Company for any claim arising out of, or
based upon, (i) the investment by such Fund in any entity competitive with the Company or (ii) actions taken by any advisor, partner, officer or other representative of the Fund to assist any such competitive entity, whether or not such
action was taken as a member of the board of directors of such competitive entity or otherwise. A “Specified Opportunity” is any matter, transaction or interest that is presented to, or acquired, created or developed by, or
which otherwise comes into the possession of, (i) the Series Preferred Directors or (ii) except for an employee of the Company or any of its subsidiaries, any holder of Preferred Stock or any partner, member, director, stockholder,
employee or agent or any such holder (together, the “Covered Persons”), unless such matter, transaction or interest is presented to, or acquired, created or developed by, or otherwise comes into the possession of a Covered
Person expressly and solely in such person’s capacity as a director of the Company. A “Fund” is an entity that is a holder of Preferred Stock and that is primarily in the business of investing in other entities, or an
entity that manages such an entity. 
 3.15    Termination of Covenants. All covenants of the Company
contained in Section 3 of this Agreement (other than the provisions of Sections 3.3, 3.6, 3.9 and 3.14) shall expire and terminate as to each Investor upon the earlier of (i) the effective date of the registration statement
pertaining to a Qualified IPO or (ii) upon an Acquisition (as defined in the Restated Charter as in effect as of the date hereof). 

SECTION 4. COVENANT OF THE INVESTORS. 

4.1    Commerce Department Compliance. The Company may be required to file reports with the Bureau of
Economic Analysis (the “BEA”) of the U.S. Commerce Department when a U.S. Affiliate of a foreign Investor if such foreign Investor, together with its affiliates, directly or indirectly controls 10% or more of the voting
securities of the Company. Such foreign Investor that is a foreign individual or entity or a U.S. subsidiary or affiliate of a foreign parent covenants to provide information necessary for the Company to comply with BEA filings required under the
International Investment and Trade in Services Act. 

  
 19 

 SECTION 5. RIGHTS OF FIRST REFUSAL. 

5.1    Subsequent Offerings. Subject to applicable securities laws, each Investor shall have a right of first
refusal to purchase its pro rata share of all Equity Securities, as defined below, that the Company may, from time to time, propose to sell and issue after the date of this Agreement, other than the Equity Securities excluded by
Section 5.6 hereof. Each Investor’s pro rata share is equal to the ratio of (a) the number of shares of the Company’s Common Stock (including all shares of Common Stock issuable or issued upon conversion of the Shares or
upon the exercise of outstanding warrants or options) of which such Investor is deemed to be a holder immediately prior to the issuance of such Equity Securities to (b) the total number of shares of the Company’s outstanding Common Stock
(including all shares of Common Stock issued or issuable upon conversion of the Shares or upon the exercise of any outstanding warrants or options) immediately prior to the issuance of the Equity Securities. The term “Equity
Securities” shall mean (i) any Common Stock, Preferred Stock or other security of the Company, (ii) any security convertible into or exercisable or exchangeable for, with or without consideration, any Common Stock, Preferred
Stock or other security (including any option to purchase such a convertible security), (iii) any security carrying any warrant or right to subscribe to or purchase any Common Stock, Preferred Stock or other security or (iv) any such
warrant or right. 
 5.2    Exercise of Rights. If the Company proposes to issue any Equity Securities, it
shall give each Investor written notice of its intention, describing the Equity Securities, the price and the terms and conditions upon which the Company proposes to issue the same. Each Investor shall have 15 days from the giving of such notice to
agree to purchase its pro rata share of the Equity Securities for the price and upon the terms and conditions specified in the notice by giving written notice to the Company and stating therein the quantity of Equity Securities to be
purchased. Notwithstanding the foregoing, the Company shall not be required to offer or sell such Equity Securities to any Investor who would cause the Company to be in violation of applicable federal securities laws by virtue of such offer or sale.

 5.3    Issuance of Equity Securities to Other Persons. If not all of the Investors elect to purchase
their pro rata share of the Equity Securities, then the Company shall promptly notify in writing the Investors who do so elect and shall offer such Investors the right to acquire such unsubscribed shares on a pro rata basis. The
Investors shall have five days after receipt of such notice to notify the Company of its election to purchase all or a portion thereof of the unsubscribed shares. The Company shall have 90 days thereafter to sell the Equity Securities in respect of
which the Investor’s rights were not exercised, at a price and upon general terms and conditions not materially more favorable to the purchasers thereof than specified in the Company’s notice to the Investors pursuant to Section 5.2
hereof. If the Company has not sold such Equity Securities within 90 days of the notice provided pursuant to Section 5.2, the Company shall not thereafter issue or sell any Equity Securities, without first offering such securities to the
Investors in the manner provided above. 
 5.4    Termination and Waiver of Rights of First Refusal. The
rights of first refusal established by this Section 5 shall not apply to, and shall terminate upon the earlier of (i) the effective date of the registration statement pertaining to a Qualified IPO or (ii) an Acquisition. 

  
 20 

 5.5    Assignment of Rights of First Refusal. The rights of
first refusal of each Investor under this Section 5 may be assigned to the same parties, subject to the same restrictions as any transfer of registration rights pursuant to Section 2.9. 

5.6    Excluded Securities. The rights of first refusal established by this Section 5 shall have no
application to any of the following Equity Securities: 
 (a)    Exempted Securities (as defined in the Restated
Charter); 
 (b)    stock issued pursuant to any such rights or agreements granted after the date of this
Agreement, so long as the rights of first refusal established by this Section 5 were complied with, waived, or were inapplicable pursuant to any provision of this Section 5.6 with respect to the initial sale or grant by the Company of such
rights or agreements; 
 (c)    any Equity Securities issued in connection with any stock split, stock dividend
or recapitalization by the Company; and 
 (d)    any Equity Securities that are issued by the Company pursuant
to a registration statement filed under the Securities Act for a Qualified IPO. 
 SECTION 6. MISCELLANEOUS. 

6.1    Governing Law. This Agreement shall be governed by and construed under the laws of the State of
Delaware in all respects as such laws are applied to agreements among Delaware residents entered into and to be performed entirely within Delaware, without reference to conflicts of laws or principles thereof. The parties agree that any action
brought by either party under or in relation to this Agreement, including without limitation to interpret or enforce any provision of this Agreement, shall be brought in, and each party agrees to and does hereby submit to the jurisdiction and venue
of, any state or federal court located in Delaware. 
 6.2    Successors and Assigns. Except as otherwise
expressly provided herein, the provisions hereof shall inure to the benefit of, and be binding upon, the parties hereto and their respective successors, assigns, heirs, executors, and administrators and shall inure to the benefit of and be
enforceable by each person who shall be a holder of Registrable Securities from time to time; provided, however, that prior to the receipt by the Company of adequate written notice of the transfer of any Registrable Securities specifying the
full name and address of the transferee, the Company may deem and treat the person listed as the holder of such shares in its records as the absolute owner and holder of such shares for all purposes, including the payment of dividends or any
redemption price. 
 6.3    Entire Agreement. This Agreement, the Exhibits and Schedules hereto, the
Purchase Agreement and the other documents delivered pursuant thereto constitute the full and entire understanding and agreement between the parties with regard to the subjects hereof and no party shall be liable or bound to any other in any manner
by any oral or written representations, warranties, covenants and agreements except as specifically set forth herein and therein. Each party expressly represents and warrants that it is not relying on any oral or written representations, warranties,
covenants or agreements outside of this Agreement. 

  
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 6.4    Severability. In the event one or more of the provisions
of this Agreement should, for any reason, be held to be invalid, illegal or unenforceable in any respect, such invalidity, illegality, or unenforceability shall not affect any other provisions of this Agreement, and this Agreement shall be construed
as if such invalid, illegal or unenforceable provision had never been contained herein. 
 6.5    Amendment and
Waiver. 
 (a)    Except as otherwise expressly provided, this Agreement may be amended or modified, and the
obligations of the Company and the rights of the Holders under this Agreement may be waived, only upon the written consent of the Company and the Requisite Investors. 

(b)    For the purposes of determining the number of Holders or Investors entitled to vote or exercise any rights
hereunder, the Company shall be entitled to rely solely on the list of record holders of its stock as maintained by or on behalf of the Company. 

6.6    Delays or Omissions. It is agreed that no delay or omission to exercise any right, power, or remedy
accruing to any party, upon any breach, default or noncompliance by another party under this Agreement shall impair any such right, power, or remedy, nor shall it be construed to be a waiver of any such breach, default or noncompliance, or any
acquiescence therein, or of any similar breach, default or noncompliance thereafter occurring. It is further agreed that any waiver, permit, consent, or approval of any kind or character on any party’s part of any breach, default or
noncompliance under the Agreement or any waiver on such party’s part of any provisions or conditions of this Agreement must be in writing and shall be effective only to the extent specifically set forth in such writing. All remedies, either
under this Agreement, by law, or otherwise afforded to any party, shall be cumulative and not alternative. 

6.7    Notices. All notices required or permitted hereunder shall be in writing and shall be deemed
effectively given: (a) upon personal delivery to the party to be notified, (b) when sent by confirmed electronic mail or facsimile if sent during normal business hours of the recipient, and if sent at a time other than the normal business
hours of the recipient, then on the next business day, (c) five days after having been sent by registered or certified mail, return receipt requested, postage prepaid, or (d) one day after deposit with a nationally recognized overnight
courier, specifying next day delivery, with written verification of receipt. All communications shall be sent to the party to be notified at the address as set forth on the signature pages hereof or Exhibit A hereto or at such other address
or electronic mail address as such party may designate by 10 days’ advance written notice to the other parties hereto. 

6.8    Attorneys’ Fees. In the event that any suit or action is instituted under or in
relation to this Agreement, including without limitation to enforce any provision in this Agreement, the prevailing party in such dispute shall be entitled to recover from the losing party all fees, costs and expenses of enforcing any right of such
prevailing party under or with respect to this Agreement, including without limitation, such reasonable fees and expenses of attorneys and accountants, which shall include, without limitation, all fees, costs and expenses of appeals. 

  
 22 

 6.9    Titles and Subtitles. The titles of the sections and
subsections of this Agreement are for convenience of reference only and are not to be considered in construing this Agreement. 

6.10    Additional Investors. Notwithstanding anything to the contrary contained herein, if the Company
shall issue additional shares of its Series B Preferred pursuant to the Purchase Agreement, any purchaser of such shares of Series B Preferred shall become a party to this Agreement by executing and delivering an additional counterpart signature
page to this Agreement and shall be deemed an “Investor,” a “Holder” and a party hereunder. 

6.11    Counterparts. This Agreement may be executed in counterparts, each of which shall be an original,
but all of which together shall constitute one instrument. 
 6.12    Aggregation of Stock. All shares of
Registrable Securities held or acquired by affiliated entities or persons or persons or entities under common management or control shall be aggregated together for the purpose of determining the availability of any rights under this Agreement. 

6.13    Pronouns. All pronouns contained herein, and any variations thereof, shall be deemed to refer to the
masculine, feminine or neutral, singular or plural, as to the identity of the parties hereto may require. 

6.14    Termination. This Agreement shall terminate and be of no further force or effect upon the earlier of
(i) an Acquisition (as defined in the Restated Charter); or (ii) the third anniversary of the closing of a Qualified IPO (as defined in the Restated Charter). 

6.15    Acknowledgement. The Company acknowledges that certain of the Investors are in the business of venture
capital investing and therefore review the business plan and related proprietary information of many enterprises, including enterprises which may have products or services which compete directly or indirectly with those of the Company. Nothing in
this Agreement shall preclude or in any way restrict the Investors from investing or participating in any particular enterprise whether or not such enterprise has products or services which compete with those of the Company. 

6.16    Prior Agreement. Upon execution and delivery of this Agreement by the Company and Investors holding at
least a majority of the Registrable Securities under the Prior Agreement, the Prior Agreement shall thereafter be of no further force and effect and is hereby amended in its entirety and restated herein, and all provisions of rights granted and
covenants made in the Prior Agreement are hereby waived, released and superseded in their entirety and shall have no further force or effect including, without limitation, all rights of first refusal and any notice period associated therewith
otherwise applicable to the transactions contemplated by the Purchase Agreement.. 
 [SIGNATURE PAGES FOLLOW] 

  
 23 

 IN WITNESS WHEREOF, the parties hereto have
executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof. 

 

	
	CRINETICS PHARMACEUTICALS, INC.
	
	Signature: /s/ R. Scot Struthers, Ph.D.                
	
	Print Name: R. Scott Struthers, Ph.D.                
	
	Title: Chief Executive Officer                            
	
	Address: 6197 Cornerstone Court, Suite 111     
	               San Diego, CA
92121                         

 IN WITNESS WHEREOF, the parties hereto have
executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof. 

 

	
	INVESTORS:
	
	5AM Ventures IV, L.P.
	
	By: 5AM Partners IV, LLC
	Its: General Partner
	
	Signature: /s/ Andrew J. Schwab                    
	
	Print Name: Andrew J. Schwab                     
	
	Title: Managing Member                               
	
	5AM Co-Investors IV, L.P.
	
	By: 5AM Partners IV, LLC
	Its: General Partner
	
	Signature: /s/ Andrew J. Schwab                    
	
	Print Name: Andrew J. Schwab                      
	
	Title: Managing
Member                                

 IN WITNESS WHEREOF, the parties hereto have
executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof. 

 

	
	INVESTORS:
	
	VERSANT VENTURE CAPITAL V, L.P.
	VERSANT AFFILIATES FUND V, L.P.
	VERSANT OPHTHALMIC AFFILIATES FUND I, L.P.
	By: Versant Ventures V, LLC, its general partner
	
	Signature: /s/ Thomas Woiwode                        
	
	Print Name: Thomas Woiwode                          
	
	Title: Managing
Director                                    
	
	VERSANT VENTURE CAPITAL V (CANADA) LP
	By: Versant Ventures V (Canada), L.P.
	 By:  Versant Ventures V, GP-GP (Canada),
Inc., its general partner

	
	Signature: /s/ Thomas Woiwode                         
	
	Print Name: Thomas Woiwode                          
	
	Title: Managing
Director                                    

 IN WITNESS WHEREOF, the parties hereto have
executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof. 

 

	
	INVESTORS:
	
	VIVO CAPITAL FUND VIII, L.P.
	By: Vivo Capital VIII, LLC
	Its: General Partner
	
	Signature: /s/ Albert
Cha                                
	
	Print Name: Albert
Cha                                 
	
	Title: Managing Member                              
	
	VIVO CAPITAL SURPLUS FUND VIII, L.P.
	By: Vivo Capital VIII, LLC
	Its: General Partner
	
	Signature: /s/ Albert
Cha                                
	
	Print Name: Albert
Cha                                 
	
	Title: Managing Member                               

 IN WITNESS WHEREOF, the parties hereto have
executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof. 

 

	
	INVESTORS:
	
	PERCEPTIVE LIFE SCIENCES MASTER FUND, LTD.
	
	By: /s/ James
Mannix                                        

	
	Print Name: James Mannix                               
	
	Title: Chief Operating Officer                          

 IN WITNESS WHEREOF, the parties hereto have
executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof. 

 

			
	INVESTORS:
	
	RA CAPITAL HEALTHCARE FUND, L.P.
	
	By: RA Capital Management, LLC
	Its: General Partner
		
	By:	 	 /s/ Nicholas McGrath

		
	Name:	 	 Nicholas McGrath

		
	Title:	 	 Authorized Signatory

 IN WITNESS WHEREOF, the parties hereto have
executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof. 

 

			
	INVESTORS:
	
	BLACKWELL PARTNERS LLC – SERIES A
		
	By:	 	 /s/ Abayomi A. Adigun

		
	Name:	 	 Abayomi A. Adigun

	  
 Title:
	 	 Investment Manager DUMAC, Inc.

Authorized Agent

		
	By:	 	 /s/ Jannine M. Lall

		
	Name:	 	 Jannine M. Lall

	  
 Title:
	 	 Controller DUMAC, Inc.

Authorized Agent

 IN WITNESS WHEREOF, the parties hereto have
executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of February 21, 2018. 

 

			
	INVESTORS:
	
	ORBIMED PRIVATE INVESTMENTS VI, LP
		
	BY:	 	ORBIMED CAPITAL GP VI LLC,
	          ITS GENERAL PARTNER
		
	By:	 	ORBIMED ADVISORS LLC,
	          ITS MANAGING MEMBER
	
	Signature: /s/ Jonathan Silverstein                    
	
	Print Name: Johnathan Silverstein                    
	
	Title:
Member                                        
            

 EXHIBIT A 

SCHEDULE OF INVESTORS 
  

	
	
                         
       NAME AND ADDRESS
                                        

 5AM VENTURES IV, L.P.
 5AM
CO-INVESTORS IV, L.P.
  

Address for all:
  

501 2nd Street, Suite 350

San Francisco, CA 94107

Attn: Andy Schwab
  

	 VERSANT VENTURE CAPITAL V, L.P.

VERSANT AFFILIATES FUND V, L.P.

VERSANT OPHTHALMIC AFFILIATES FUND I, L.P.

VERSANT VENTURE CAPITAL V (CANADA) LP

 
 Address for all:

 
 One Sansome Street, Suite 3630

San Francisco, CA 94104

Attn: Robin L. Praeger
  

	 VIVO CAPITAL FUND VIII, L.P.

VIVO CAPITAL SURPLUS FUND VIII, L.P.

 
 Address for all:

 
 505 Hamilton Ave., Suite 207

Palo Alto, CA 94301

Attn: Albert Cha
  

	 PERCEPTIVE LIFE SCIENCES MASTER FUND LTD

51 Astor Place, 10th Floor

New York, NY 10003
 Attn: Michael Altman

E-mail: Michael@perceptivelife.com
  

With a copy to:
  

Tannenbaum Helpern Syracuse & Hirschtritt LLP
 900 Third
Avenue
 New York, NY 10022
 Attn: David R. Lallouz

E-mail: lallouz@thsh.com

	
	 RA CAPITAL HEALTHCARE FUND, L.P.

20 Park Plaza, Suite 1200

Boston, MA 02116

Attn: Nicholas McGrath

	
	 Blackwell Partners LLC – Series A

280 S. Mangum Street, Suite 210

Durham, NC 27701
 Attn:
Jannine Lall

	
	 OrbiMed Private Investments VI, LP

601 Lexington Avenue, 54th Floor

New York, NY 10022
 Attn:
General CounselEX-10.1

 Exhibit 10.1 

CRINETICS PHARMACEUTICALS, INC. 

2015 STOCK INCENTIVE PLAN 

(As Amended and Restated Effective October 30, 2015) 

This is the 2015 Stock Incentive Plan (the “Plan”), established by Crinetics Pharmaceuticals, Inc., a Delaware corporation
(the “Company”), as originally adopted by its Board of Directors as of February 16, 2015, and as further amended and restated by its Board of Directors effective as of October 30, 2015 (the “Effective Date”).

 ARTICLE 1. 

PURPOSES OF THE PLAN 

1.1    Purposes.    The purposes of the Plan
are (a) to enhance the Company’s ability to attract and retain the services of qualified employees, officers and directors (including non-employee officers and directors), and consultants and other service providers upon whose judgment,
initiative and efforts the successful conduct and development of the Company’s business largely depends (“Key Team Members”), and (b) to provide additional incentives to such persons or entities to devote their utmost
effort and skill to the advancement and betterment of the Company, by providing them an opportunity to participate in the ownership of the Company and thereby have an interest in the success and increased value of the Company. 

ARTICLE 2. 
 DEFINITIONS

 For purposes of this Plan, the following terms shall have the meanings indicated: 

2.1    Administrator.    
“Administrator” means the Board or, if the Board delegates responsibility for any matter to the Committee, the term Administrator shall mean the Committee. 

2.2    Affiliated Company.    “Affiliated
Company” means any “parent corporation” or “subsidiary corporation” of the Company, whether now existing or hereafter created or acquired, as those terms are defined in Sections 424(e) and 424(f) of the Code, respectively.

 2.3    Award.    “Award” means
any Option, Restricted Stock or Stock Appreciation Right granted to a Participant under the Plan. 

2.4    Award Agreement.    “Award
Agreement” means any Option Agreement, Restricted Stock Purchase Agreement or Stock Appreciation Rights Agreement entered into between the Company and a Participant under the Plan. 

2.5    Base Value.    “Base Value” shall have the meaning set forth in
Section 7.3 hereof. 

2.6    Board.    “Board” means the Board of Directors of the Company.

 2.7    Cause.    “Cause” shall, unless otherwise defined in
a Participant’s written employment agreement or Award Agreement, mean: (a) the commission of any act of fraud, embezzlement or dishonesty by Participant which adversely affects the business of the Company, the acquiring or successor entity
(or parent or any subsidiary thereof), (b) any unauthorized use or disclosure by Participant of 

  
 1 

 
confidential information or trade secrets of the Company, the acquiring or successor entity (or parent or any subsidiary thereof), (c) the refusal or omission by the Participant to perform any
duties required of him if such duties are consistent with duties customary for the position held with the Company, the acquiring or successor entity (or parent or any subsidiary thereof), (d) any act or omission by the Participant involving
malfeasance or gross negligence in the performance of Participant’s duties to, or deviation from any of the policies or directives of, the Company or the acquiring or successor entity (or parent or any subsidiary thereof), (e) conduct on the
part of Participant which constitutes the breach of any statutory or common law duty of loyalty to the Company, the acquiring or successor entity (or parent or any subsidiary thereof), or (f) any illegal act by Participant which adversely
affects the business of the Company, the acquiring or successor entity (or parent or any subsidiary thereof), or any felony committed by Participant, as evidenced by conviction thereof. 

2.8    Change in Control.    “Change in Control” means the occurrence
of any of the following: 
 (a)    If the Company has a class of securities
registered pursuant to Section 12 of the Exchange Act, a change in the effective control of the Company which occurs on the date that a majority of members of the Board is replaced during any twelve (12) month period by directors whose
appointment or election is not endorsed by a majority vote of the members of the Board before the date of the appointment or election. For purposes of this clause (a), if any Person is considered to be in effective control of the Company, the
acquisition of additional control of the Company by the same Person will not be considered a Change in Control; 

(b)    The date that any one person, or more than one person acting as a Group
(“Person”) acquires ownership of stock of the Company that, together with stock held by such Person, constitutes more than fifty percent (50%) of the total fair market value or total voting power of the stock of the Company,
provided that a Change in Control shall not be deemed to occur (i) on account of the acquisition of securities of the Company directly from the Company, (ii) on account of the acquisition of securities of the Company by an investor, any
affiliate thereof or any other Person that acquires the Company’s securities in a transaction or series of related transactions the primary purpose of which is to obtain financing for the Company through the issuance of equity securities or
(iii) solely because the level of ownership held by any Person exceeds the designated percentage threshold of the outstanding voting securities as a result of a repurchase or other acquisition of voting securities by the Company reducing the
number of shares outstanding, provided that if a Change in Control would occur (but for the operation of this sentence) as a result of the acquisition of voting securities by the Company, and after such share acquisition, the Person becomes the
owner of any additional voting securities that, assuming the repurchase or other acquisition had not occurred, increases the percentage of the then outstanding voting securities owned by the Person over the designated percentage threshold, then a
Change in Control shall be deemed to occur; or 
 (c)    a change in the ownership of
a substantial portion of the assets of the Company which occurs on the date that any Person acquires (or has acquired during the twelve (12) month period ending on the date of the most recent acquisition by such Person) assets of the Company
and its subsidiaries (taken as a whole) that have a total gross fair market value equal to or more than fifty percent (50%) of the total gross fair market value of all of the assets of the Company and its subsidiaries (taken as a whole) immediately
prior to such acquisition or acquisitions. For purposes of this clause (c), gross fair market value means the value of the assets of the Company, or the value of the assets being disposed of, determined without regard to any liabilities associated
with such assets. 
 Notwithstanding the foregoing, a transaction will not be deemed a Change in Control unless the transaction qualifies as
a change in control event within the meaning of Code Section 409A, as it has been and may be amended from time to time, and any proposed or final Treasury Regulations and Internal Revenue Service guidance that has been promulgated or may be
promulgated thereunder from time to 

  
 2 

 
time. Further and for the avoidance of doubt, a transaction will not constitute a Change in Control if: (i) its sole purpose is to change the jurisdiction of the Company’s
incorporation, or (ii) its sole purpose is to create a holding company that will be owned in substantially the same proportions by the persons who held the Company’s securities immediately before such transaction. 

2.9    Code.    “Code” means the Internal Revenue Code of 1986, as
amended from time to time, and applicable Treasury Regulations and administrative guidance promulgated thereunder. 

2.10    Committee.    “Committee” means a committee of two or more
members of the Board appointed to administer the Plan pursuant to Section 8.1 hereof. 

2.11    Common Stock.    “Common Stock” means the Common Stock of the
Company. 
 2.12    Company.    “Company” shall have the meaning set
forth in the preamble to this Plan. 

2.13    Consultant.    “Consultant” means any consultant or
advisor if: (a) the consultant or advisor renders bona fide services to the Company or any Affiliated Company; (b) the services rendered by the consultant or advisor are not in connection with the offer or sale of securities in a
capital-raising transaction and do not directly or indirectly promote or maintain a market for the Company’s securities; and (c) the consultant or advisor is a natural person who has contracted directly with the Company or any Affiliated
Company to render such services. 
 2.14    Continuous
Service.    Unless otherwise provided in an Award Agreement, the terms of which may be different from the following, “Continuous Service” means (a) Participant’s employment by either the Company or any
Affiliated Company, or by successor entity following a Change in Control, which is uninterrupted except for vacations, illness (not including Disability), or leaves of absence which are approved in writing by the Company or any of such other
employer corporations, as applicable, (b) service as a member of the Board until the Participant resigns, is removed from office, or Participant’s term of office expires and he or she is not reelected, or (c) so long as the
Participant is engaged as a Consultant or other Service Provider. 

2.15    Disability.    “Disability” means permanent and
total disability as defined in Section 22(e)(3) of the Code. The Administrator’s determination of a Disability or the absence thereof shall be conclusive and binding on all interested parties. 

2.16    Effective Date.    “Effective Date” shall have the meaning set
forth in the preamble to this Plan. 

  
 3 

 2.17    Equity
Restructuring.    “Equity Restructuring” means, as determined by the Administrator, a non-reciprocal transaction between the Company and its stockholders,
such as a stock dividend, stock split, spin-off or recapitalization through a large, nonrecurring cash dividend, that affects the shares of Common Stock (or other securities of the Company) or the share price
of Common Stock (or other securities of the Company) and causes a change in the per share value of the Common Stock underlying outstanding Awards. 

2.18    Established Securities Market.    “Established
Securities Market” means either: (a) a securities exchange registered with the Securities and Exchange Commission under Section 6 of the Exchange Act; (b) a foreign national securities exchange officially recognized, sanctioned
or supervised by governmental authority; or (c) an OTC Market. 
 2.19    Exchange
Act.    “Exchange Act” means the Securities and Exchange Act of 1934, as amended. 

2.20    Exercise Price.    “Exercise Price” means the
purchase price per share of Common Stock payable upon exercise of an Option. 
 2.21    Fair Market
Value.    “Fair Market Value” on any given date means the value of a share of Common Stock, determined as follows: 

(a)    If the Common Stock is then readily tradable on an Established Securities
Market, the Fair Market Value shall be determined by the Administrator through the application of a valuation method permitted under Treasury Regulation Section 1.409A-1(b)(5)(iv)(A); and 

(b)    If the Common Stock is not then readily tradable on an Established Securities
Market, the Fair Market Value shall be determined by the Administrator in good faith through the reasonable application of a reasonable valuation method in accordance with Treasury Regulation Section 1.409A-1(b)(5)(iv)(B), which determination
shall be conclusive and binding on all interested parties. 
 2.22    FINRA
Dealer.    “FINRA Dealer” means a broker-dealer that is a member of the Financial Industry Regulatory Authority, Inc. 

2.23    Group.    “Group” is as defined in paragraph (i)(5)(v)(B) of
Treasury Regulation Section 1.409A-3. 
 2.24    Incentive
Option.    “Incentive Option” means any Option designated and qualified as an “incentive stock option” as defined in Section 422 of the Code. 

2.25    New Incentives.    “New Incentives” shall have the meaning set
forth in Section 9.1(a) hereof. 

  
 4 

 2.26    Nonqualified
Option.    “Nonqualified Option” means any Option that is not an Incentive Option. To the extent any Option designated as an Incentive Option fails in whole or in part to qualify as an Incentive Option,
including without limitation, for failure to meet the requirements applicable to 10% Stockholders or because the annual limit described in Section 5.7 hereof is exceeded, it shall to that extent constitute a Nonqualified
Option. 
 2.27    Option.    “Option” means any option to purchase
Common Stock granted pursuant to Article 5 hereof. 
 2.28    Option
Agreement.    “Option Agreement” means the written agreement entered into between the Company and an Optionee with respect to an Option granted under the Plan. 

2.29    Optionee.    “Optionee” means a Participant who holds an
Option. 
 2.30    OTC Market.    “OTC Market” means an
over-the-counter market reflected by the existence of an interdealer quotation system. 

2.31    Participant.    “Participant” means a Key Team Member that
holds an Option, Restricted Stock or Stock Appreciation Right granted pursuant to the Plan. 

2.32    Plan.    “Plan” means this amended and restated 2015 Stock
Incentive Plan of the Company. 
 2.33    Publicly
Held.    “Publicly Held” means, with respect to the Company, any point in time in which any class of common equity securities of the Company are required to be registered under Section 12 of the Exchange
Act. 
 2.34    Purchase Price.    “Purchase Price” means the
purchase price payable to purchase a share of Restricted Stock. 
 2.35    Repurchase
Right.    “Repurchase Right” means the right of the Company to repurchase shares of Common Stock issued pursuant to an Award granted under the Plan. 

2.36    Restricted Stock.    “Restricted Stock” means shares of Common
Stock issued pursuant the Plan, subject to any restrictions and conditions as are established pursuant to Article 6 hereof. 

2.37    Restricted Stock Purchase Agreement.    “Restricted Stock
Purchase Agreement” means the written agreement entered into between the Company and a Participant with respect to the purchase of Restricted Stock under the Plan. 

2.38    Securities Act.    “Securities Act” means the Securities Act of
1933, as amended. 
 2.39    Service Provider.    “Service
Provider” means a Consultant or other natural person the Administrator authorizes to become a Participant in the Plan and who provides services to: (a) the Company; (b) an Affiliated Company; or (c) any other business venture
designated by the Administrator in which the Company (or any entity that is a successor to the Company) or an Affiliated Company has a significant ownership interest. 

2.40    Stock Appreciation Right.    “Stock Appreciation
Right” means a contractual right granted to a Participant pursuant to Article 7 hereof, the exercise or settlement of which entitles the Participant to receive shares of Common Stock, cash, or a combination of Common Stock and cash,
equal 

  
 5 

 
to the difference between the Base Value per share of the Stock Appreciation Right and the Fair Market Value of a share of Common Stock on the date of exercise or settlement, multiplied by the
number of shares subject to the Stock Appreciation Right at such time, and subject to such conditions set forth in this Plan and the applicable Stock Appreciation Rights Agreement. 

2.41    Stock Appreciation Rights Agreement.    “Stock
Appreciation Rights Agreement” means the written agreement entered into between the Company and a Participant with respect to a Stock Appreciation Right granted under the Plan. 

2.42    10% Stockholder.    “10% Stockholder” means a
person who, as of a relevant date, owns or is deemed to own (by reason of the attribution rules applicable under Section 424(d) of the Code) stock possessing more than 10% of the total combined voting power of all classes of stock of the
Company or of an Affiliated Company measured as of an Incentive Option’s date of grant. 

2.43    Treasury Regulations.    “Treasury Regulations” shall mean the
regulations of the United States Treasury Department promulgated under the Code. 
 ARTICLE 3. 

ELIGIBILITY 

3.1    Incentive Options.    Only employees of the Company or of an
Affiliated Company (including officers of the Company and members of the Board if they are employees of the Company or of an Affiliated Company) are eligible to receive Incentive Options under the Plan. 

3.2    Nonqualified Options, Restricted Stock and Stock Appreciation
Rights.    Employees of the Company or of an Affiliated Company, members of the Board (whether or not employed by the Company or an Affiliated Company), and Service Providers are eligible to receive Nonqualified Options,
Restricted Stock or Stock Appreciation Rights under the Plan. 
 3.3    Section 162(m)
Limitation.    On and after such time, if any, that the Company is Publicly Held, no employee of the Company or of an Affiliated Company shall be eligible to be granted Options or Stock Appreciation Rights covering more
than 1,000,000 shares of Common Stock during any calendar year; provided, however, the preceding limitation shall not apply until the earliest time required for compensation attributable to Options or Stock Appreciation Rights granted
under the Plan to be exempt from the deduction limitation of Section 162(m) of the Code. 
 ARTICLE 4. 

PLAN SHARES 

4.1    Shares Subject to the Plan.    Subject
to Section 4.2, a total of Five Million Four Hundred Forty Thousand (5,440,000) shares of Common Stock shall be available for issuance under the Plan. Of this total, Five Million Four Hundred Forty Thousand (5,440,000) shares of Common Stock
are available for issuance pursuant to Incentive Options. For purposes of this Section 4.1, in the event that (a) all or any portion of any Award granted or offered under the Plan can no longer under any circumstances
be exercised or (b) any shares of Common Stock are reacquired by the Company which were initially the subject of an Award Agreement, the shares of Common Stock allocable to the unexercised portion of such Award, or the shares so reacquired,
shall again be available for grant or issuance under the Plan. 

4.2    Changes in Capital Structure. 

  
 6 

 (a)    In the event that the outstanding shares of Common Stock are hereafter
increased or decreased or changed into or exchanged for a different number or kind of shares or other securities of the Company by reason of a recapitalization, stock split, reverse stock split, combination of shares, reclassification, stock
dividend, or other change in the capital structure of the Company, then appropriate adjustments shall be automatically made to the aggregate number and kind of shares subject to this Plan, the number and kind of shares and the exercise price or
purchase price per share subject to outstanding Award Agreements, and the limits on the number of shares under Sections 3.3 and 4.1 hereof, all in order to preserve, as nearly as practical, but not to increase, the benefits to
Participants. 
 (b)    In connection with the occurrence of any Equity Restructuring, and notwithstanding anything to
the contrary in this Section 4.2, the Administrator will equitably adjust each outstanding Award, which adjustments may include adjustments to the number and type of securities subject to each outstanding Award and/or the
exercise price or grant price thereof, if applicable, the grant of new Awards to Participants, and/or the making of a cash payment to Participants, as the Administrator deems appropriate to reflect such Equity Restructuring. The adjustments provided
under this Section 4.2(b) shall be nondiscretionary and shall be final and binding on the affected Participant and the Company; provided that whether an adjustment is equitable shall be determined by the Administrator. 

ARTICLE 5. 
 OPTIONS

 5.1    Option Agreement.    Each
Option granted pursuant to this Plan shall be evidenced by an Option Agreement that shall specify the number of shares subject thereto, the Exercise Price per share, and whether the Option is an Incentive Option or Nonqualified Option. As soon as is
practical following the grant of an Option, an Option Agreement shall be duly executed and delivered by or on behalf of the Company to the Optionee to whom such Option is granted. Each Option Agreement shall be in such form and contain such
additional terms and conditions, not inconsistent with the provisions of this Plan, as the Administrator shall, from time to time, deem desirable, including without limitation, the imposition of any rights of first refusal and resale obligations
upon any shares of Common Stock acquired pursuant to an Option Agreement. Each Option Agreement may be different from each other Option Agreement. 

5.2    Exercise Price.    The Exercise Price
per share of Common Stock covered by each Option shall be determined by the Administrator, provided that (a) the Exercise Price shall not be less than 100% of the Fair Market Value per share of Common Stock on the date the Option is granted,
and (b) in the case of an Incentive Option granted to a 10% Stockholder, the Exercise Price shall not be less than 110% of the Fair Market Value per share of Common Stock on the date the Incentive Option is granted. However, an Option may be
granted with an Exercise Price lower than that set forth in the preceding sentence if such Option is granted pursuant to an assumption or substitution for another option in a manner satisfying the provisions of Sections 409A and 424 of the Code, as
applicable. 
 5.3    Payment of Exercise
Price.    Payment of the Exercise Price shall be made upon exercise of an Option and may be made, in the discretion of the Administrator, subject to any restrictions under applicable corporate law, by: (a) cash; (b)
check; (c) surrender of shares of Common Stock acquired pursuant to the exercise of an Option, which surrendered shares shall be valued at Fair Market Value as of the date of such exercise; (d) delivery of a promissory note in a form and
with such recourse, interest, security and other provisions as the Administrator determines to be appropriate (subject to applicable corporate law); (e) cancellation of indebtedness of the Company to the Optionee; (f) waiver of compensation due
or accrued to the Optionee for services rendered; (g) provided that a public market for the Common Stock exists, a “same day sale” commitment from the Optionee and an FINRA Dealer whereby the Optionee irrevocably elects to exercise
the Option and to sell a portion of the shares so 

  
 7 

 
purchased to pay for the Exercise Price and whereby the FINRA Dealer irrevocably commits upon receipt of such shares to forward the Exercise Price directly to the Company; (h) provided that
a public market for the Common Stock exists, a “margin” commitment from the Optionee and an FINRA Dealer whereby the Optionee irrevocably elects to exercise the Option and to pledge the shares so purchased to the FINRA Dealer in a margin
account as security for a loan from the FINRA Dealer in the amount of the Exercise Price, and whereby the FINRA Dealer irrevocably commits upon receipt of such shares to forward the Exercise Price directly to the Company; (i) a “net
exercise” arrangement pursuant to which the Company will reduce the number of shares of Common Stock to be issued upon exercise by the number of shares of Common Stock having an aggregate Fair Market Value as of the date of exercise equal to
the total Exercise Price; or (j) any combination of the foregoing methods of payment or any other consideration or method of payment as shall be permitted by applicable corporate law. 

5.4    Term and Termination of Options.    The
term and provisions for termination of each Option shall be as fixed by the Administrator, but no Option may be exercisable more than ten (10) years after the date it is granted or such shorter period as specified in the Option Agreement. An
Incentive Option granted to a person who is a 10% Stockholder on the date of grant shall not be exercisable more than five (5) years after the date it is granted. 

5.5    Date of Grant.    The date of grant of
an Option will be the date on which the Administrator makes the determination to grant such Option, unless a later date is otherwise specified by the Administrator. The Option Agreement and a copy of this Plan will be delivered to the Optionee
within a reasonable time after the granting of the Option. 

5.6    Vesting and Exercise of
Options.    Each Option shall vest and become exercisable in one or more installments at such time or times and subject to such conditions, including without limitation, the achievement of specified performance goals or
objectives, as shall be determined by the Administrator. Notwithstanding the foregoing, if necessary to comply with applicable laws, each Option granted to an employee of the Company or Affiliated Company shall provide that the employee shall have
the right to exercise the vested portion of any Option held at the termination of the employee’s Continuous Service for at least thirty (30) days following termination of the employee’s Continuous Service for any reason other than
Cause (but not more than ninety (90) days) and that the employee (or employee’s designee) shall have the right to exercise the Option for at least six (6) months if such termination of employee’s Continuous Service is due to the
death or Disability of the employee. 
 5.7    Annual Limit on Incentive
Options.    To the extent required for “incentive stock option” treatment under Section 422 of the Code, if the aggregate Fair Market Value (determined as of the date of grant) of the Common Stock with
respect to which Incentive Options granted under this Plan and any other plan of the Company or any Affiliated Company becomes exercisable for the first time by an Optionee during any calendar year exceeds $100,000, such excess shall be a
Nonqualified Option. In the event that the Code or the regulations promulgated thereunder are amended after the Effective Date to provide for a different limit on the Fair Market Value of Shares permitted to be subject to “incentive stock
options” (as defined in Section 422 of the Code), then such different limit will be automatically incorporated herein and will apply to any Incentive Options granted after the effective date of such amendment. 

5.8    Nontransferability of
Options.    Except as otherwise provided by the Administrator in an Option Agreement and as permissible under applicable law, no Option shall be assignable or transferable except by will or the laws of descent and
distribution and during the life of the Optionee shall be exercisable only by such Optionee. Notwithstanding the forgoing, the Administrator may grant Nonqualified Options that may be transferred to a revocable trust or as otherwise permitted under
Rule 701 of the Securities Act. 

  
 8 

 5.9    Rights as
Stockholder.    An Optionee or permitted transferee of an Option shall have no rights or privileges as a stockholder with respect to any shares covered by an Option until such Option has been duly exercised and shares
purchased upon such exercise have been issued to such person. 
 5.10    Unvested
Shares.    The Administrator shall have the discretion to grant Options that are exercisable for unvested shares of Common Stock on such terms and conditions as the Administrator shall determine from time to time. 

5.11    Company’s Repurchase Right.    In the event of a
termination of an Optionee’s Continuous Service for any reason whatsoever (including death or Disability), the Option Agreement may provide, in the discretion of the Administrator, that the Company, or its assignee, shall have the right,
exercisable at the discretion of the Administrator, to repurchase shares of Common Stock acquired pursuant to the exercise of an Option at any time on such terms as may be provided in the Option Agreement. The repurchase price for shares repurchased
by the Company shall be as set forth in the document evidencing the Repurchase Right, subject to the following requirements: 

(a)    In the case of vested shares, the repurchase price shall be equal to the Fair Market Value per share of
Common Stock as of the date of termination of Optionee’s Continuous Service; and 

(b)    In the case of unvested shares, the repurchase price may be equal to one
of the following: (i) the Fair Market Value per share of Common Stock as of the date of termination of Optionee’s Continuous Service, (ii) the Exercise Price paid per share, or (iii) the lesser of (A) the Exercise Price paid
per share, or (B) the Fair Market Value per share of Common Stock as of the date of termination of Optionee’s Continuous Service. 

The terms upon which the Company’s Repurchase Right shall be exercisable (including but not limited to the period and procedure for
exercise and the timing and method of payment for the purchased shares) shall be established by the Administrator and set forth in the document evidencing such Repurchase Right. 

5.12    Compliance with Code
Section 409A.    Notwithstanding anything in this Article 5 to the contrary, to the extent that any Option is subject to Code Section 409A, the Option is intended to be structured to
satisfy the requirements of Code Section 409A, or an applicable exemption, as determined by the Administrator. 
 ARTICLE 6. 

RESTRICTED STOCK 

6.1    Issuance and Sale of Restricted
Stock.    The Administrator shall have the authority to grant Restricted Stock under this Plan, subject to such terms, restrictions and conditions as the Administrator may determine at the time of grant. Such conditions
may include, but are not limited to, continued employment or the achievement of specified performance goals or objectives. The Purchase Price of Restricted Stock, which may include zero dollars ($0), shall be determined by the Administrator in its
sole discretion. 
 6.2    Restricted Stock Purchase
Agreements.    A Participant shall have no rights with respect to the shares of Restricted Stock covered by a Restricted Stock Purchase Agreement until the Participant has paid the full Purchase Price to the Company in
the manner set forth in Section 6.3 hereof and has executed and delivered to the Company the Restricted Stock Purchase Agreement. Each Restricted Stock Purchase Agreement shall be in such form, and shall set forth the
Purchase Price and such other terms, 

  
 9 

 
conditions and restrictions of the Restricted Stock, not inconsistent with the provisions of this Plan, as the Administrator shall, from time to time, deem desirable. Each Restricted Stock
Purchase Agreement may be different from each other Restricted Stock Purchase Agreement. The Restricted Stock will be accepted by the Participant’s execution and delivery of the Restricted Stock Purchase Agreement and full payment for the
Shares to the Company within thirty (30) days from the date the Restricted Stock Purchase Agreement is delivered to the person. If such person does not execute and deliver the Restricted Stock Purchase Agreement along with full payment for the
Shares to the Company within such thirty (30) days, then the offer will terminate, unless otherwise determined by the Administrator. 

6.3    Payment of Purchase Price.    Subject
to any restrictions under applicable corporate law, payment of the Purchase Price may be made, in the discretion of the Administrator, by: (a) cash; (b) check; (c) surrender of shares of Common Stock owned by the Participant, which
surrendered shares shall be valued at Fair Market Value as of the date of such acceptance; (d) delivery of a promissory note in a form and with such recourse, interest, security and other provisions as the Administrator determines to be
appropriate (subject to applicable corporate law); (e) cancellation of indebtedness of the Company to the Participant; (f) the waiver of compensation due or accrued to the Participant for services rendered; or (g) any combination of the
foregoing methods of payment or any other consideration or method of payment as shall be permitted by applicable corporate law. 

6.4    Rights as a Stockholder.    Upon
complying with the provisions of Section 6.2 hereof, a Participant shall have the rights of a stockholder with respect to the Restricted Stock purchased pursuant to a Restricted Stock Purchase Agreement, including voting
and dividend rights, subject to the terms, restrictions and conditions as are set forth in such Restricted Stock Purchase Agreement. Unless the Administrator shall determine otherwise, certificates evidencing shares of Restricted Stock shall remain
in the possession of the Company until such shares have vested in accordance with the terms of the Restricted Stock Purchase Agreement. 

6.5    Transfer Restrictions.    Shares of
Restricted Stock may not be sold, assigned, transferred, pledged or otherwise encumbered or disposed of except as specifically provided in the Restricted Stock Purchase Agreement. 

6.6    Company’s Repurchase Right.    In
the event of a termination of a Participant’s Continuous Service with the Company for any reason whatsoever (including death or Disability), the Restricted Stock Purchase Agreement may provide, in the discretion of the Administrator, that the
Company shall have the right, exercisable at the discretion of the Administrator, to repurchase shares of Common Stock acquired pursuant to a Restricted Stock Purchase Agreement, on such terms as may be provided in the Restricted Stock Purchase
Agreement. The repurchase price for shares repurchased by the Company shall be as set forth in the document evidencing the Repurchase Right, subject to the following requirements: 

(a)    In the case of vested shares, the repurchase price shall be equal to the Fair Market Value per share of
Common Stock as of the date of termination of Participant’s Continuous Service; and 

(b)    In the case of unvested shares, the repurchase price may be equal to one of the
following: (i) the Fair Market Value per share of Common Stock as of the date of termination of Participant’s Continuous Service, (ii) the original Purchase Price paid per share, if any, or (iii) the lesser of (A) the
original Purchase Price paid per share, if any, or (B) the Fair Market Value per share of Common Stock as of the date of termination of Participant’s Continuous Service. 

The terms upon which such Repurchase Right shall be exercisable (including but not limited to the period and procedure for exercise and the
timing and method of payment for the purchased shares) 

  
 10 

 
shall be established by the Administrator and set forth in the document evidencing such Repurchase Right. 

6.7    Vesting of Restricted Stock.    The
Restricted Stock Purchase Agreement shall specify the date or dates, the performance goals or objectives which must be achieved, and any other conditions on which the Restricted Stock may vest. 

6.8    Dividends.    If payment for shares of
Restricted Stock is made by promissory note, any cash dividends paid with respect to the Restricted Stock may be applied, in the discretion of the Administrator, to repayment of such note. 

6.9    Compliance with Code
Section 409A.    Notwithstanding anything in this Article 6 to the contrary, to the extent that a Restricted Stock Award is subject to Code Section 409A of the Code, the
Restricted Stock Award is intended to be structured to satisfy the requirements of Code Section 409A, or an applicable exemption, as determined by the Administrator. 

ARTICLE 7. 
 STOCK
APPRECIATION RIGHTS 
 7.1    Grant of Stock Appreciation
Rights.    The Administrator shall have the authority to grant Stock Appreciation Rights subject to such terms, restrictions and conditions as the Administrator may determine at the time of grant. Stock Appreciation
Rights may be granted on a basis that allows for the exercise of the right by the Participant, or that provides for the automatic settlement of the right upon a specified date or event, for shares of Common Stock, cash or a combination of Common
Stock and cash. 
 7.2    Stock Appreciation Rights
Agreements.    Each Stock Appreciation Right granted pursuant to this Plan shall be evidenced by a Stock Appreciation Rights Agreement, which shall specify the number of shares subject thereto, vesting provisions relating
to such Stock Appreciation Right, the Base Value per share, and whether the Stock Appreciation Right shall be exercisable or subject to settlement for shares of Common Stock, cash or a combination of Common Stock and cash. As soon as is practicable
following the grant of a Stock Appreciation Right, a Stock Appreciation Rights Agreement shall be duly executed and delivered by or on behalf of the Company to the Participant to whom such Stock Appreciation Right was granted. Each Stock
Appreciation Rights Agreement shall be in such form and contain such additional terms and conditions, not inconsistent with the provisions of this Plan, as the Administrator shall, from time to time, deem desirable, including without limitation, the
imposition of any rights of first refusal and resale obligations upon any shares of Common Stock acquired pursuant to a Stock Appreciation Right. Each Stock Appreciation Rights Agreement may be different from each other Stock Appreciation Rights
Agreement. 
 7.3    Base Value.    The Base
Value per share of Common Stock covered by each Stock Appreciation Right shall be determined by the Administrator, except that the Base Value of a Stock Appreciation Right shall not be less than 100% of Fair Market Value of the Common Stock on the
date the Stock Appreciation Right is granted. 
 7.4    Term and
Termination of Stock Appreciation Rights.    The term and provisions for termination of each Stock Appreciation Right shall be fixed by the Administrator, but no Stock Appreciation Right may be exercisable or subject to
settlement more than ten (10) years after the date it is granted or such shorter period as specified in the Award Agreement. 

7.5    Vesting and Exercise of Stock Appreciation
Rights.    Each Stock Appreciation Right 

  
 11 

 
shall vest, and become exercisable or subject to settlement, in one or more installments at such time or times and shall be subject to such conditions, including without limitation the
achievement of specified performance goals or objectives established with respect to one or more performance criteria, as shall be determined by the Administrator. Notwithstanding the foregoing, if necessary to comply with applicable laws, each
Stock Appreciation Right granted to an employee of the Company or Affiliated Company, on a basis that allows the right to be exercised by the employee, shall provide that the employee shall have the right to exercise the vested portion of such right
held at the termination of the employee’s Continuous Service for at least thirty (30) days following termination of the employee’s Continuous Service for any reason other than Cause and that the employee (or employee’s designee)
shall have the right to exercise the Stock Appreciation Right for at least six (6) months if such termination of the employee’s Continuous Service is due to the death or Disability of the employee. 

7.6    Payment of Appreciation.    A Stock
Appreciation Right will entitle the holder, upon exercise or settlement of the Stock Appreciation Right, as applicable, to receive an amount determined by multiplying: (a) the excess of the Fair Market Value of a share of Common Stock on the
date of exercise or settlement of the Stock Appreciation Right over the Base Value of such Stock Appreciation Right, by (b) the number of shares as to which such Stock Appreciation Right is exercised or settled. Upon exercise or settlement,
payment of the appreciation determined under the preceding formula shall be made in shares of Common Stock, cash, or a combination of both shares and cash, as set forth in the Stock Appreciation Rights Agreement in the discretion of the
Administrator. To the extent that payment is made in shares of Common Stock, such shares shall be valued at their Fair Market Value on the date of exercise or settlement. 

7.7    Nontransferability of Stock Appreciation
Rights.    Except as otherwise provided by the Administrator in an Stock Appreciation Rights Agreement and as permissible under applicable law, no Stock Appreciation Right shall be assignable or transferable except by
will, the laws of descent and distribution or pursuant to a domestic relations order, and during the life of the Participant shall be exercisable only by such Participant. Notwithstanding the forgoing, the Administrator may grant Stock Appreciation
Rights that may be transferred to a revocable trust or as otherwise permitted under Rule 701 of the Securities Act. 

7.8    Rights as a Stockholder.    A
Participant shall have no rights or privileges as a stockholder with respect to any shares covered by a Stock Appreciation Right until such Stock Appreciation Right has been duly exercised or settled and certificates representing shares issued upon
such exercise or settlement have been issued to such person. 

7.9    Unvested Shares.    The Administrator
shall have the discretion to grant Stock Appreciation Rights that may be exercised or settled for unvested shares of Common Stock on such terms and conditions as the Administrator shall determine from time to time. 

7.10    Company’s Repurchase Right.    In the event of a
termination of a Participant’s Continuous Service for any reason whatsoever (including death or Disability), the Stock Appreciation Rights Agreement may provide, in the discretion of the Administrator, that the Company, or its assignee, shall
have the right, exercisable at the discretion of the Administrator, to repurchase shares of Common Stock acquired pursuant to the exercise or settlement of a Stock Appreciation Right at any time on such terms as may be provided in the Stock
Appreciation Right Agreement. The repurchase price for shares repurchased by the Company shall be equal to the Fair Market Value per share of Common Stock as of the date of termination of Participant’s Continuous Service. The terms upon which
such Repurchase Right shall be exercisable (including but not limited to the period and procedure for exercise and the timing and method of payment for the purchased shares) shall be established by the Administrator and set forth in the document
evidencing such Repurchase Right. 

  
 12 

 7.11    Compliance with Code
Section 409A.    Notwithstanding anything in this Article 7 to the contrary, all Stock Appreciation Rights Awards are intended to be structured to satisfy the requirements of Code
Section 409A, or an applicable exemption, as determined by the Administrator. 
 ARTICLE 8. 

ADMINISTRATION OF THE PLAN 

8.1    Administrator.    Authority to control
and manage the operation and administration of the Plan shall be vested in the Board, which may delegate such responsibilities in whole or in part to a committee consisting of two (2) or more members of the Board. Members of the Committee may
be appointed from time to time by, and shall serve at the pleasure of, the Board. When and if the Company becomes Publicly Held, the Board may limit the composition of the Committee to those persons necessary to comply with the requirements of
Section 162(m) of the Code and Section 16 of the Exchange Act. 

8.2    Delegation to an Officer.    To the
extent authorized by applicable law, the Board may delegate to one or more officers of the Company the authority to do one or both of the following: (a) designate officers and employees of the Company or any of its subsidiary corporations to be
recipients of Options or Stock Appreciation Rights and (b) determine the number of shares of Common Stock to be subject to such Options or Stock Appreciation Rights granted to such officers and employees of the Company; provided, however, that
the resolutions of the Board regarding such delegation shall specify the total number of shares of Common Stock that may be subject to the Options or Stock Appreciation Rights granted by such officer and that such officer may not grant an Option or
Stock Appreciation Right to himself or herself. Notwithstanding the foregoing, the Board may not delegate authority to an officer to determine the Fair Market Value of the Common Stock. 

8.3    Powers of the Administrator.    In
addition to any other powers or authority conferred upon the Administrator elsewhere in the Plan or by law, the Administrator shall have full power and authority: (a) to determine the persons to whom, and the time or times at which Awards shall
be granted, the number of shares of Common Stock to be represented by each Option or Stock Appreciation Rights Agreement and the number of shares of Common Stock to be subject to each Restricted Stock Purchase Agreement, and the consideration to be
received by the Company upon the exercise of such Options or Stock Appreciation Right or sale of Restricted Stock; (b) to interpret the Plan; (c) to create, amend or rescind rules and regulations relating to the Plan; (d) to determine
the terms, conditions and restrictions contained in, and the form of, Award Agreements; (e) to determine the identity or capacity of any persons who may be entitled to exercise a Participant’s rights under any Award Agreement under the
Plan; (f) to correct any defect or supply any omission or reconcile any inconsistency in the Plan or in any Award Agreement; (g) to accelerate the vesting of any Award or release or waive any Repurchase Rights of the Company with respect
to any Award; (h) to extend the exercise date of any Option or Stock Appreciation Right (but not beyond the original expiration date); (i) to provide for rights of first refusal and/or Repurchase Rights; (j) to amend outstanding Award
Agreements to provide for, among other things, any change or modification which the Administrator could have included in the original Award Agreement or in furtherance of the powers provided for herein; (k) to make all other determinations
necessary or advisable for the administration of the Plan, but only to the extent not contrary to the express provisions of the Plan; and (l) grant Awards to Key Team Members who are foreign nationals on such terms and conditions different from
those specified in the Plan as is necessary or desirable to promote achievement of the purposes of the Plan, and adopt such modifications, procedures, and/or subplans and the like as may be necessary or desirable to comply with the provisions of the
laws or regulations of other countries or jurisdictions to ensure the viability of the benefits from Awards granted to such Key Team Members employed in such countries or jurisdictions, or to meet the requirements that permit the Plan to operate in

  
 13 

 
a qualified or tax efficient manner, and/or comply with applicable foreign laws or regulations. Any action, decision, interpretation or determination made in good faith by the Administrator in
the exercise of its authority conferred upon it under the Plan shall be final and binding on the Company and all Participants. The Administrator’s decisions and determinations need not be uniform and may be made selectively among Participants
in the Committee’s sole discretion. 

8.4    Section 409A of the
Code.    Notwithstanding anything in this Plan to the contrary, to the extent that Awards are subject to Section 409A of the Code, (a) any adjustments made pursuant to this Article 8 to Awards that are
considered “deferred compensation” within the meaning of Section 409A of the Code shall be made in compliance with the requirements of Section 409A of the Code; (b) any adjustments made pursuant to Article 8 to Awards that
are not considered “deferred compensation” subject to Section 409A of the Code shall be made in such a manner as to ensure that after such adjustment the Awards either (i) continue not to be subject to Section 409A of the
Code or (ii) comply with the requirements of Section 409A of the Code; and (c) in any event, the Administrator shall not have the authority to make any adjustments pursuant to Article 8 to the extent the existence of such authority
would cause an Award that is not intended to be subject to Section 409A of the Code at the time of grant to be subject thereto. 

8.5    Limitation on Liability.    No employee
of the Company or member of the Board or Committee shall be subject to any liability with respect to duties under the Plan unless the person acts fraudulently or in bad faith. To the extent permitted by law, the Company shall indemnify each member
of the Board or Committee, and any employee of the Company with duties under the Plan, who was or is a party, or is threatened to be made a party, to any threatened, pending or completed proceeding, whether civil, criminal, administrative or
investigative, by reason of such person’s conduct in the performance of duties under the Plan. 
 ARTICLE 9. 

CHANGE IN CONTROL 

9.1    Change in Control. 

(a)    The Administrator, in connection with a Change in Control transaction, either by the terms of the Award or by
action taken prior to the occurrence of such Change in Control and either automatically or upon the Participant’s request, is hereby authorized to take any one or more of the following actions whenever the Administrator determines, in its sole
discretion, that such action is appropriate in order to facilitate such Change in Control:  

(i)    To provide for the cancellation of any such Award in exchange for either an amount of cash or other
property with a value equal to the amount that could have been obtained upon the exercise or settlement of such Award or realization of the Participant’s rights had such Award been currently exercisable, payable and fully vested, as applicable;
provided that, if the amount that could have been obtained upon the exercise or settlement of such Award or realization of the Participant’s rights, in any case, is equal to or less than zero, then such Award may be terminated without payment;

 (ii)    To provide that such Award shall vest and, to the extent applicable, be exercisable as to all
shares covered thereby, notwithstanding anything to the contrary in the Plan or the provisions of such Award; 

(iii)    To provide that such Award be assumed by the successor or survivor corporation, or a parent or
subsidiary thereof, or shall be substituted for by awards covering the stock of the successor or survivor corporation, or a parent or subsidiary thereof, with appropriate adjustments as 

  
 14 

 
to the number and kind of shares and applicable exercise or purchase price, in all cases, as determined by the Administrator; 

(iv)    To make adjustments in the number and type of shares of Common Stock (or other securities or
property) subject to outstanding Awards, and/or in the terms and conditions of (including the grant or exercise price), and the criteria included in, outstanding Awards which may be granted in the future; 

(v)    To replace such Award with other rights or property selected by the Administrator; and/or 

(vi)    To provide that the Award will terminate and cannot vest, be exercised or become payable after the
Change in Control. 
 (b)    Notwithstanding Section 9.1(a) above, vesting of all outstanding
Options and Stock Appreciation Rights shall accelerate automatically effective as of immediately prior to the consummation of the Change in Control unless the Options and Stock Appreciation Rights are to be assumed by the acquiring or successor
entity (or parent or subsidiary thereof) or new options or new stock appreciation rights under a new stock incentive program (“New Incentives”) of comparable value are to be issued in exchange therefor, as provided in subsection
(c) below. 
 (c)    Vesting of outstanding Options and Stock Appreciation
Rights shall not accelerate if and to the extent that: (i) the Options and Stock Appreciation Rights (including the unvested portions thereof) are to be assumed by the acquiring or successor entity (or parent or subsidiary thereof) pursuant to
the terms of the Change in Control transaction, or (ii) the Options and Stock Appreciation Rights (including the unvested portions thereof) are to be replaced by the acquiring or successor entity (or parent or subsidiary thereof) with New
Incentives of comparable value containing such terms and provisions as the Administrator in its discretion may consider equitable. If outstanding Options or Stock Appreciation Rights are assumed, or if New Incentives of comparable value are issued
in exchange therefor, then each such Option, Stock Appreciation Right or New Incentive shall be appropriately adjusted, concurrently with the Change in Control, to apply to the number and class of securities or other property that the Participant,
as the case may be, would have received pursuant to the Change in Control transaction in exchange for the shares issuable upon exercise of the Option or Stock Appreciation Right had the Option or Stock Appreciation Right been exercised immediately
prior to the Change in Control, and appropriate adjustment also shall be made to the Exercise Price such that the aggregate Exercise Price of each such Option or new option and the aggregate Base Value of each such Stock Appreciation Right or new
stock appreciation right shall remain the same as nearly as practicable. 
 (d)    If
any Option or Stock Appreciation Right is assumed by an acquiring or successor entity (or parent or subsidiary thereof) or a New Incentive of comparable value is issued in exchange therefor pursuant to the terms of a Change in Control transaction,
then if so provided in the Option Agreement or Stock Appreciation Rights Agreement, the vesting of the Option, Stock Appreciation Right, or the New Incentive shall accelerate if and at such time as the Participant’s service as an employee,
director, officer, Consultant or other Service Provider to the acquiring or successor entity (or a parent or subsidiary thereof) is terminated involuntarily or voluntarily under certain circumstances within a specified period following consummation
of the Change in Control, pursuant to such terms and conditions as shall be set forth in the Option Agreement or Stock Appreciation Rights Agreement. 

(e)    Outstanding Options and Stock Appreciation Rights shall terminate and cease to be exercisable upon consummation of
a Change in Control except to the extent that the Options and Stock Appreciation Rights are assumed by the successor entity (or parent or subsidiary thereof) pursuant to the terms of the Change in Control transaction. 

  
 15 

 (f)    If outstanding Options or Stock
Appreciation Rights will not be assumed by the acquiring or successor entity (or parent or subsidiary thereof), or such Awards are not purchased or exchanged for New Incentives, the Administrator shall cause written notice of a proposed Change in
Control transaction to be given to Participants holding such Awards not less than five (5) days prior to the anticipated effective date of the proposed transaction. 

(g)    Notwithstanding Section 9.1(a) above, all Repurchase Rights of the Company under this
Plan shall automatically terminate immediately prior to the consummation of such Change in Control, and the shares of Common Stock subject to such terminated Repurchase Rights shall immediately vest in full, except to the extent that: (a) in
connection with such Change in Control, the acquiring or successor entity (or parent or subsidiary thereof) provides for the continuance or assumption of the Restricted Stock Purchase Agreements (or such other agreements evidencing the
Company’s Repurchase Right, as applicable) or the substitution of new agreements of comparable value covering shares of a successor corporation, with appropriate adjustments as to the number and kind of shares and purchase price, or
(b) such accelerated vesting is precluded by other limitations imposed by the Administrator in the Restricted Stock Purchase Agreement (or such other agreement evidencing the Company’s Repurchase Right, as applicable) at the time the
shares are issued. 
 (h)    The Administrator in its discretion may provide in any
Restricted Stock Purchase Agreement (or such other agreement evidencing the Company’s Repurchase Right, as applicable) that if, upon a Change in Control, the acquiring or successor entity (or parent or subsidiary thereof) provides for the
continuance or assumption of such Restricted Stock Purchase Agreement (or such other agreement evidencing the Company’s Repurchase Right, as applicable) or the substitution of new agreements of comparable value covering shares of a successor
corporation (with appropriate adjustments as to the number and kind of shares and purchase price), then any Repurchase Right provided for in such Restricted Stock Purchase Agreement (or such other agreement evidencing the Company’s Repurchase
Right, as applicable) shall terminate, and the shares of Common Stock subject to the terminated Repurchase Right or any substituted shares shall immediately vest in full, if the Participant’s service as an employee, director, officer,
Consultant or other Service Provider to the acquiring or successor entity (or a parent or subsidiary thereof) is terminated involuntarily or voluntarily under certain circumstances within a specified period following consummation of a Change in
Control pursuant to such terms and conditions as shall be set forth in the Restricted Stock Purchase Agreement (or such other agreement evidencing the Company’s Repurchase Right, as applicable). 

ARTICLE 10. 
 AMENDMENT
AND TERMINATION OF THE PLAN 
 10.1    Amendments.    The
Board may from time to time alter, amend, suspend or terminate the Plan in such respects as the Board may deem advisable. No such alteration, amendment, suspension or termination shall be made which shall (i) substantially affect or impair the
rights of any Participant under an outstanding Award Agreement without such Participant’s consent, or (ii) cause this Plan, or any Award granted pursuant to it, to violate Code Section 409A. The Board may alter or amend the Plan to
comply with requirements under the Code relating to Incentive Options or other types of options that give Optionees more favorable tax treatment than that applicable to Options granted under this Plan as of the date of its adoption. Upon any such
alteration or amendment, any outstanding Award granted hereunder may, if the Administrator so determines and if permitted by applicable law, be subject to the more favorable tax treatment afforded to a Participant pursuant to such terms and
conditions. 
 10.2    Plan Termination.    Unless the Plan shall
theretofore have been terminated, the Plan 

  
 16 

 
shall terminate on the tenth (10th) anniversary of the Effective Date and no Awards may be granted under the Plan thereafter, but Award Agreements then outstanding shall continue in effect in
accordance with their respective terms. 
 ARTICLE 11. 

TAXES 

11.1    Tax Withholding.    The Company shall have the power to
withhold, or require a Participant to remit to the Company, an amount sufficient to satisfy any applicable Federal, state, and local tax withholding requirements with respect to any Options or Stock Appreciation Rights exercised or shares of
Restricted Stock issued under this Plan. To the extent permissible under applicable tax, securities and other laws, the Administrator may, in its sole discretion and upon such terms and conditions as it may deem appropriate, permit a Participant to
satisfy his or her obligation to pay any such tax, in whole or in part, by (a) directing the Company to apply shares of Common Stock to which the Participant is entitled as a result of the exercise of an Option or Stock Appreciation Right or as
a result of the purchase of or lapse of restrictions on shares of Restricted Stock or (b) delivering to the Company shares of Common Stock owned by the Participant; provided, however, the amount withheld shall not exceed the amount necessary to
satisfy the Company’s tax withholding obligations at the minimum statutory withholding rates, as applicable. The shares of Common Stock so applied or delivered in satisfaction of the Participant’s tax withholding obligation shall be valued
at their Fair Market Value as of the date of measurement of the amount of income subject to withholding. 
 ARTICLE 12. 

MISCELLANEOUS 

12.1    Benefits Not Alienable.    Other than as provided above,
benefits under the Plan may not be assigned or alienated, whether voluntarily or involuntarily. Any unauthorized attempt at assignment, transfer, pledge or other disposition shall be without effect. 

12.2    No Enlargement of Employee Rights.    This Plan is strictly
a voluntary undertaking on the part of the Company and shall not be deemed to constitute a contract between the Company and any Participant to be consideration for, or an inducement to, or a condition of, the employment of any Participant. Nothing
contained in the Plan shall be deemed to give the right to any Participant to be retained as an employee of the Company or any Affiliated Company or to limit the right of the Company or any Affiliated Company to discharge any Participant at any
time. 
 12.3    Application of Funds.    The proceeds received
by the Company from the sale of Common Stock pursuant to Option Agreements and Restricted Stock Purchase Agreements, except as otherwise provided herein, will be used for general corporate purposes. 

12.4    Financial Reports.    To the extent required by Rule 701(e)
of the Securities Act, the Company shall provide, at least annually, summary financial information relating to the Company’s financial condition and results of operations to each Participant who holds one or more Awards or shares of Common
Stock issued pursuant to the Plan. 
 12.5    Adoption and Stockholder
Approval.    This amended and restated Plan will become effective on the Effective Date and will be approved by the stockholders of the Company (excluding Shares issued pursuant to this Plan), consistent with applicable
laws, within twelve (12) months before or after the Effective Date. Upon the Effective Date, the Administrator may grant Awards pursuant to this Plan; provided, however, that: (a) no Option or Stock Appreciation Right may be exercised
prior to 

  
 17 

 
initial stockholder approval of this Plan; (b) no Option or Stock Appreciation Right granted pursuant to an increase in the number of Shares approved by the Administrator shall be exercised
prior to the time such increase has been approved by the stockholders of the Company; (c) in the event that initial stockholder approval is not obtained within the time period provided herein, all Awards shall be canceled, any Shares issued
pursuant to any such Award shall be canceled and any purchase of such Shares issued hereunder shall be rescinded; and (d) Awards granted pursuant to an increase in the number of Shares approved by the Administrator which increase is not
approved by stockholders within the time then required, any Shares issued pursuant to any such Awards shall be canceled, and any purchase of Shares subject to any such Award shall be rescinded. 

12.6    Electronic Delivery.    Any reference herein to a
“written” agreement or document shall include any agreement or document delivered electronically or posted on the Company’s intranet. 

  
 18 

 2015 PLAN AMENDMENT 

THIS AMENDMENT NO. 1 TO THE CRINETICS PHARMACEUTICALS, INC. 2015 STOCK INCENTIVE PLAN, as amended, (this “Amendment”),
dated as of February 9, 2018, is made and adopted by Crinetics Pharmaceuticals, Inc., a Delaware corporation (the “Company”). Capitalized terms used but not otherwise defined herein shall have the meanings ascribed to
them in the Plan (as defined below). 
 RECITALS 

WHEREAS, the Company has adopted the Crinetics Pharmaceuticals, Inc. 2015 Stock Incentive Plan (the “Plan”); 

WHEREAS, the Company desires to amend the Plan as set forth below; 

WHEREAS, pursuant to Section 10.1 of the Plan, the Plan may be amended by the Board of Directors of the Company; and 

WHEREAS, the Board of Directors of the Company has approved this Amendment pursuant to resolutions adopted on February 8, 2018. 

NOW, THEREFORE, in consideration of the foregoing, the Company hereby amends the Plan as follows: 

1.     Section 4.1 of the Plan is hereby amended to read as follows: 

“4.1    Shares Subject to the
Plan.    Subject to Section 4.2, a total of Seven Million Nine Hundred Forty Thousand (7,940,000) shares of Common Stock shall be available for issuance under the Plan. Of this total, Seven Million Nine Hundred Forty
Thousand (7,940,000) shares of Common Stock are available for issuance pursuant to Incentive Options. For purposes of this Section 4.1, in the event that (a) all or any portion of any Award granted or offered under the
Plan can no longer under any circumstances be exercised or (b) any shares of Common Stock are reacquired by the Company which were initially the subject of an Award Agreement, the shares of Common Stock allocable to the unexercised portion of
such Award, or the shares so reacquired, shall again be available for grant or issuance under the Plan.” 

2.    This Amendment shall be and is hereby incorporated in and forms a part of the Plan. All other terms and provisions
of the Plan shall remain unchanged except as specifically modified herein. The Plan, as amended by this Amendment, is hereby ratified and confirmed. 

 I hereby certify that the foregoing Amendment was duly adopted by the Board of Directors of
Crinetics Pharmaceuticals, Inc. on February 8, 2018. 
  

			
	By:	 	 /s/ Marc Wilson

	Name:	 	Marc Wilson
	Title:	 	Secretary

 Signature Page to 2015 Stock Incentive Plan Amendment

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