Document:

Exhibit 4.3

 

FIXED RATE GLOBAL NOTE

NO.[           ]

 

	
  Registered

  	
   

  	
   

  
	
  CUSIP No.

  	
   

  	
  40429CCS9

  
	
  ISIN No.

  	
   

  	
  US40429CCS98

  

 

Unless this certificate
is presented by an authorized representative of The Depository Trust Company, a
New York corporation (“DTC”), to Issuer or its agent for registration of
transfer, exchange or payment and any certificate issued is registered in the
name of Cede & Co. or in such other name as is requested by an
authorized representative of DTC (and any payment is made to Cede &
Co. or to such other entity as is requested by an authorized representative of
DTC), ANY TRANSFER, PLEDGE, OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO
ANY PERSON IS WRONGFUL inasmuch as the registered owner hereof, Cede &
Co., has an interest herein.

 

HSBC FINANCE CORPORATION

 

GLOBAL NOTE

 

representing

 

5% Notes due June 30, 2015

 

HSBC
FINANCE CORPORATION, a Delaware corporation (herein called the “Company”, which
term includes any successor corporation under the Indenture hereinafter
referred to), for value received hereby promises to pay to CEDE &
CO., or registered assigns, the principal sum of $500,000,000 and to
pay interest thereon at the rate per annum of 5%.  The Company will pay interest from June 27,
2005, or from the most recent Interest Payment Date to which interest has been
paid or duly provided for, semi-annually on June 30 and December 30
of each year (beginning on December 30, 2005), until the principal hereof
is paid or duly provided for.  The
interest so payable, and punctually paid or duly provided for, on any Interest
Payment Date will, as provided in the Indenture, be paid to the Holder of this
Note (or one or more Predecessor Notes) of record at the close of business on
the Regular Record Date for such interest, which shall be the preceding June 15
and December 15, respectively (whether or not a Business Day), except that
interest payable at maturity shall be paid to the same Person to whom the
principal of this Note is payable. Interest will be computed on the basis of a
360-day year of twelve 30-day months. 
Any such interest not so punctually paid or duly provided for shall
forthwith cease to be payable to the Holder on such Regular Record Date, and
may be paid to the Holder of this Note (or one or more Predecessor Notes) of
record at the close of business on a Special Record Date fixed by the Trustee
for the payment of such defaulted interest, notice whereof shall be given to
Holders not less than 10 days prior to such Special Record Date, or may be paid
at any time in any other lawful manner not

 

5 % Fixed Rate Note
No.  [001]

 

 

inconsistent with the
requirements of any securities exchange on which the Notes may be listed, and
upon such notice as may be required by such exchange, all as more fully
provided in the Indenture.  Payment of the
principal of this Note and, unless otherwise paid as hereinafter provided, the
interest (if any) thereon will be made at the office or agency of the Company
in New York, New York or at such other office or agency as designated by the
Trustee, in such coin or currency of the United States of America as at the
time of payment is legal tender for payment of public and private debts;
provided, however, that payment of interest may be made at the option of the
Company by check or draft mailed to the Person entitled thereto at the address
appearing in the Note Register. 
Additional provisions of this Note are set forth on the reverse hereof.

 

Unless
the certificate of authentication hereon has been executed by or on behalf of
the Trustee, by manual signature, this Global Note shall not be entitled to any
benefit under the Indenture, or be valid or obligatory for any purpose.

 

 

IN WITNESS WHEREOF, the Company has caused this Global
Note to be duly executed.

 

THIS
GLOBAL NOTE MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE DEPOSITORY OR
BY A NOMINEE OF THE DEPOSITORY TO THE DEPOSITORY OR ANOTHER NOMINEE OF THE
DEPOSITORY OR BY THE DEPOSITORY OR ANY SUCH NOMINEE TO A SUCCESSOR OF THE
DEPOSITORY OR A NOMINEE OF SUCH SUCCESSOR.

 

 

	
   

  	
   

  	
  HSBC FINANCE
  CORPORATION

  
	
   

  	
   

  	
   

  
	
  ATTEST:

  	
   

  	
   

  	
  By:

  	
   

  	
   

  
	
  Name:

  	
  Michael J. Forde

  	
  Name:

  	
  Edgar D. Ancona

  
	
  Title: 

  	
  Assistant
  Secretary

  	
  Title:

  	
  Senior Vice
  President - Treasurer

  
							

 

CERTIFICATE OF AUTHENTICATION

 

This is one of the Global Notes of the series designated herein
referred to in the within mentioned Indenture.

 

Dated:    June 27, 2005

 

	
  BNY Midwest Trust Company, as Trustee

  
	
   

  
	
  By:

  	
   

  	
   

  
	
  Title:

  	
   

  	
   

  

 

 

[Reverse of Note]

 

HSBC FINANCE CORPORATION

5% NOTES DUE JUNE 30, 2015

 

This
Note is one of a duly authorized issue of notes of the Company (herein called the
“Notes”), issuable in series, unlimited in aggregate principal amount except as
may be otherwise provided in respect of the Notes of a particular series,
issued and to be issued under and pursuant to an Indenture dated as of December 15,
2004, duly executed and delivered by the Company to BNY Midwest Trust Company,
as Trustee, and is one of a series designated as 5% Notes due June 30,
2015 (herein called the “5% Notes”). 
Reference is hereby made to the Indenture dated as of December 15,
2004 and all indentures supplemental thereto (hereinafter called the “Indenture”)
and the Board Resolutions creating the 5% Notes (the “Board Resolutions”) for a
description of the rights, limitations of rights, obligations, duties and
immunities thereunder of the Trustee, the Company and the Holders.  The 5% Notes are general unsecured
obligations of the Company.

 

The 5%
Notes are not redeemable prior to maturity and are not entitled to any sinking
fund, except under certain limited circumstances relating to the obligation of
the Company to pay Additional Amounts (as defined herein).  The Company will, subject to certain
exceptions and limitations set forth in the Board Resolutions, pay as
additional interest, such amounts (“Additional Amounts”) as are necessary in
order that the net payment by the Company or a paying agent of the principal of
and interest thereon on the 5% Notes to a holder who is a non-United States
person (as defined below), after deduction for any present or future tax,
assessment or other governmental charge of the United States or any political
subdivision or taxing authority thereof or therein, imposed by withholding with
respect to the payment, will not be less than the amount provided herein to be
then due and payable.  Each reference to
payment of principal and interest herein shall be deemed to include any such
Additional Amounts.  If, as a result of
any change in, or amendment to, the laws (or any regulations or rulings
promulgated thereunder) of the United States (or any political subdivision or
taxing authority thereof or therein), or any change in, or amendments to, an
official position regarding the application or interpretation of such laws,
regulations or rulings, which change or amendment is announced or becomes
effective on or after June 20, 2005, the Company becomes or, based upon a
written opinion of independent counsel selected by the Company, will become
obligated to pay Additional Amounts as described herein, then the Company may
at its option redeem, as a whole, but not in part, the 5% Notes on not less
than 30 nor more than 60 days prior notice, at a redemption price equal to 100%
of their principal amount, together with interest accrued but unpaid thereon to
the date fixed for redemption.

 

“Non-United
States person” means any person other than (i) a citizen or resident of
the United States, (ii) a corporation or partnership (including any entity
treated as a corporation or partnership for United States federal income tax
purposes) created or organized in or under the laws of the United States, any
state thereof or the District of Columbia, or (iii) an estate or trust
treated as a United States person under section 7701(a)(30) of the
Internal Revenue Code of 1986, as amended.

 

 

If any
Event of Default with respect to Notes of this series shall occur and be
continuing, the principal of all the 5% Notes may be declared due and payable
in the manner and with the effect provided in the Indenture.

 

The
Indenture contains provisions for defeasance at any time of the entire
indebtedness of the Company on the 5% Notes upon compliance by the Company with
certain conditions set forth therein, which provisions apply to this Note.

 

The
Indenture permits, with certain exceptions as therein provided, the amendment
thereof and the modification of the rights and obligations of the Company and
the rights of the Holders under the Indenture at any time by the Company with
the consent of the Holders of at least a majority in aggregate principal amount
of the Notes at the time Outstanding of each series which is affected by such
amendment or modification, except that certain amendments specified in the
Indenture may be made without approval of Holders of the Notes.  The Indenture also contains provision
permitting the Holders of a majority in aggregate principal amount of the
Outstanding Notes of any series to waive on behalf of the Holders of such
series of Notes compliance by the Company with certain provisions of the
Indenture and certain past defaults under the Indenture and their consequences.  Any such consent or waiver by the Holder of
this Note shall be binding upon such Holder and upon all future Holders of this
Note and any Note issued upon the registration of transfer hereof or in
exchange herefor or in lieu hereof whether or not notation of such consent or
waiver is made upon this Note.

 

No
reference herein to the Indenture and no provision of this Note or of the
Indenture shall alter or impair the obligation of the Company, which is
absolute and unconditional, to pay the principal of and interest on this 5%
Note at the times, place and rate, and in the coin or currency herein
prescribed.

 

As
provided in the Indenture and subject to certain limitations therein set forth,
transfer of this 5% Note is registrable on the Note Register, upon surrender of
this 5% Note for registration of transfer at the office or agency of the
Company in New York, New York duly endorsed by, or accompanied by a written
instrument of transfer in form satisfactory to the Company and the Note
Registrar duly executed by, the Holder hereof or his attorney duly authorized
in writing, and thereupon one or more new 5% Notes, of authorized denominations
and for a like aggregate principal amount, will be issued to the designated
transferee or transferees.

 

The 5% Notes are issuable only as
registered Notes without coupons in denominations of $5,000 or in integral
multiples of $1,000 in excess thereof authorized by the Company.  As provided in the Indenture and subject to
certain limitations therein set forth, Notes are exchangeable for a like
aggregate principal amount of Notes of the same series containing identical
terms and provisions and of different authorized denominations, as requested by
the Holder surrendering the same.

 

No
service charge will be made for any such registration of transfer or exchange,
but the Company may require payment of a sum sufficient to cover any tax or
other governmental charge payable in connection therewith.

 

 

The
Company, the Trustee and any agent of the Company or the Trustee may treat the
Person in whose name this Note is registered as the owner hereof for the
purpose of receiving payment as herein provided and for all other purposes
whether or not this Note be overdue, and neither the Company, the Trustee nor
any such agent shall be affected by notice to the contrary.

 

This
5% Note is exchangeable by the Company only if (x) the Depository notifies the
Company that it is unwilling or unable to continue as Depository for this
Global Note or if at any time the Depository ceases to be a clearing agency registered
under the Securities Exchange Act of 1934, as amended and a successor
depositary has not been appointed by the Company within 90 days, (y) the
Company in its sole discretion determines that this 5% Note shall be
exchangeable for certificated Notes in registered form, or (z) an Event of
Default (as defined in the Prospectus) has occurred and is continuing with
respect to the Notes; provided, that the certificated Notes so issued by the
Company in exchange for this permanent Global Note shall be in denominations of
$5,000 and any integral multiple of $1,000 in excess thereof and be of like
aggregate principal amount and tenor as the portion of this permanent Global
Note to be exchanged, and provided further that, unless the Company agrees
otherwise, Notes of this series in certificated registered form will be issued
in exchange for this permanent Global Note, or any portion hereof, only if such
Notes in certificated registered form were requested by written notice to the
Trustee or the Securities Registrar by or on behalf of a Person who is
beneficial owner of an interest hereof given through the Holder hereof.  Except as provided above, owners of
beneficial interests in this permanent Global Note will not be entitled to
receive physical delivery of Notes in certificated registered form and will not
be considered the Holders thereof for any purpose under the Indenture.

 

All
terms used in this Note which are defined in the Indenture have the meanings
assigned to them in the Indenture.

 

 

ASSIGNMENT FORM

 

FOR
VALUE RECEIVED, the undersigned hereby sells, assigns and transfers unto

 

	
   

  	
   

  
	
  Name and Address of Assignee

  
	
   

  
	
   

  	
  (

  	
   

  	
  )

  
	
   

  	
   

  
	
  Social Security Number

  or other identifying

  number of Assignee

  
	
   

  
	
   

  
	
  the within
  Global Note and all rights thereunder, hereby irrevocably constituting and
  appointing                          
  Attorney to transfer said Global Notes on the books of the Company, with full
  power of substitution in premises.

  
	
   

  
	
  Dated:

  	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
  NOTICE:
  The Signature to this Assignment must correspond with the name written upon
  the face of this Note in every particular, without alteration or enlargement
  or any change whatever.Exhibit
10.1

 

AMENDMENT NO. 1 TO COMMON STOCK
PURCHASE WARRANT

 

This AMENDMENT NO. 1 TO COMMON STOCK PURCHASE WARRANT
(the “Amendment”) is entered into as of June 24,
2005 by and among EXACT Sciences Corporation, a Delaware corporation (the “Company”) and Laboratory Corporation of America Holdings,
Inc. as the holder of the Company’s Common Stock Purchase Warrant issued on June
26, 2002 (the “Warrant”).

 

RECITALS

 

A.            The Company issued the Warrant to the Holder,
in connection with that certain License Agreement between the Company and the
Holder, dated as of June 26, 2002 (the “License Agreement”),
to acquire 1,000,000 shares of Common Stock of the Company, at an exercise
price of $16.09 per share, for a period of three (3) years from the date of
issuance thereof.

 

B.            The License Agreement was subsequently
amended on January 19, 2004 to, among other things, extend the period of
exclusivity under the License Agreement to August 13, 2008.

 

C.            In order to promote and support the
activities and programs contemplated by the parties to be performed by the
Holder in an effort to increase the commercial sales of the Assay (as defined
in the License Agreement, as amended) during the exclusivity period under the
License Agreement, the Company and the Holder hereby desire to amend the Warrant
pursuant to Section 14 of the Warrant, on the terms and conditions set forth
herein, to extend the term of the Warrant to August 13, 2008.

 

NOW, THEREFORE, BE IT RESOLVED, that for good and
valuable consideration, the receipt and sufficiency of which is hereby
acknowledged, the parties hereto agree as follows:

 

1.             Increase in Term.  Notwithstanding
anything to contrary set forth in the Warrant, the term of the Warrant is
hereby extended to the close of business on August 13, 2008, and Section 6 of the
Warrant is hereby amended and restated in its entirety as follows:

 

“6.           Expiration Date. This Warrant shall expire at the close
of business on August 13, 2008 and shall be void thereafter.”

 

2.             No Further Amendment.  Except
as amended hereby, the Warrant shall remain in full force and effect.

 

3.             Successors and Assign. 
This Amendment shall be binding upon the Company’s successors and
assigns and shall inure to the benefit of the Holder’s successors, legal
representatives and permitted assigns.

 

[Remainder of Page Intentionally Left Blank]

 

1

 

IN WITNESS
WHEREOF, the undersigned have executed this Amendment as of the date first
written above.

 

	
   

  	
  EXACT SCIENCES
  CORPORATION

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  By:

  	
  /s/ Harry W. Wilcox,
  III

  	
   

  
	
   

  	
  Name: Harry W. Wilcox,
  III

  
	
   

  	
  Title: Senior Vice
  President, Chief Financial Officer

  and Treasurer

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  LABORATORY CORPORATION
  OF AMERICA

  HOLDINGS, INC.

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  By:

  	
  /s/ Bradford T. Smith

  	
   

  
	
   

  	
  Name: Bradford T. Smith

  
	
   

  	
  Title: Executive Vice
  President

  
					

 

2

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