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                                                                     EXHIBIT 4.5

CONFIDENTIAL TREATMENT - EDITED COPY

                       AMENDMENT NO. 1 TO OPTION AGREEMENT

                                                               December 19, 2000

UBS AG, London Branch
c/o UBS Warburg LLC
[****]
[****]

Dear Sirs:

        Reference is hereby made to the Option Agreement, dated October 26, 2000
(the "Option Agreement"), between SciClone Pharmaceuticals, Inc. (the "Company")
and you. Capitalized terms not defined herein have the meanings ascribed to them
in the Option Agreement.

        Pursuant to your election today under Section 1(c) of the Option
Agreement to exchange the two series of Options issued to date for Options of a
single series (the "New Option"), the Company and you hereby agree to amend the
terms of the Option Agreement as follows:

        (1)    the combined purchase price of the two series of Options issued
               to date under the Option Agreement shall be $900,000 of which
               $840,000 has been previously paid;

        (2)    the convertible note underlying the New Option shall (i) have an
               aggregate principal amount of $5,913,044, (ii) be convertible
               initially into 407,610 Shares, and (iii) have the terms
               (including as to maturity date) set forth in the form of
               convertible note attached hereto as Annex I; and

        (3)    you and the Company hereby agree that you will not purchase any
               further series of Options pursuant to the Option Agreement.

        In addition, the Company and you hereby agree to further amend the
Option Agreement by deleting Section 2 thereof in its entirety and inserting in
its place the following (and references therein to Annex I shall be deemed to be
references to the form of convertible note attached hereto as Annex I):

               "2.    EXERCISE OF CALL OPTION.

                      (a) The Purchaser may exercise any Options issued
        hereunder at any time on or prior to December 7, 2005, by delivering a
        written notice to the Company (a "Purchaser's Call Option Notice")
        requiring the Company to issue and sell (in which event the Purchaser
        shall purchase) Convertible Notes covered by such Option having the
        principal amount specified in such notice (but not less than $1,000,000
        nor in excess of

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CONFIDENTIAL TREATMENT - EDITED COPY

        the maximum amount covered by such Option as specified in the applicable
        terms) and the Conversion Rate specified in the applicable terms but
        having the maturity date and in all other respects having the terms set
        forth in the form attached hereto as Annex I (and with the applicable
        series designation, principal amount and Conversion Rate inserted
        therein), at a purchase price of 100% of the principal amount thereof.

                      (b) Any issuance of Convertible Notes will be effected on
        the basis of the representations and warranties and subject to the terms
        and conditions set forth herein, against payment of the above-specified
        purchase price therefor. The closing of the issuance and acceptance of
        such Convertible Notes against such payment shall take place on such
        date and time as may be specified in the Purchaser's Call Option Notice
        but no earlier than three Business Days and no later than twenty
        Business Days after the date of delivery of the Purchaser's Call Option
        Notice, at which time the Company shall deliver to the Purchaser such
        Convertible Notes in certificated form against delivery by the Purchaser
        of a wire transfer of the purchase price to the Company's account
        [****]. Upon the occurrence of any Change of Control, the Company shall
        take appropriate action to ensure that the Purchaser shall have the
        right to exercise the Options after the Change of Control.

                      (c) Subject to the conditions set forth in this Section
        2(c), the Company, upon five business days' notice to the Purchaser, may
        elect, in lieu of delivering Convertible Notes pursuant to this Section
        2, to deliver the number of shares of Common Stock determined pursuant
        to the following formula:

               N  = P x  CR
                        ----
                        1000

               where  N = the number of shares of Common Stock so
                          deliverable,

                      P = the principal amount of the Convertible Notes in
                          lieu of which such shares of Common Stock are
                          delivered; and

                     CR = the Conversion Rate of the Convertible Notes in
                          lieu of which such shares of Common Stock are
                          delivered, as set forth in the applicable terms.

                      (d) The Company covenants and agrees with the Purchaser
        that:

                             (1) If any Convertible Notes or shares of Common
                      Stock to be issued in lieu thereof pursuant to this
                      Section 2 require registration with or approval of any
                      governmental authority under any State law or any other
                      Federal law before such shares may be validly issued or
                      delivered, such registration shall have been completed,
                      have become effective and such approval shall have been
                      obtained, in each case, at or prior to the time of
                      issuance of such Convertible Notes or shares;

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CONFIDENTIAL TREATMENT - EDITED COPY

                             (2) The shares of Common Stock issuable upon
                      conversion of such Convertible Notes or so deliverable
                      shall have been approved for quotation in the Nasdaq
                      National Market or listed on a national securities
                      exchange at or prior to the time of issuance of such
                      Convertible Notes or shares; and

                             (3) All shares of Common Stock issuable upon
                      conversion of such Convertible Notes or so deliverable
                      shall be issued out of the Company's authorized but
                      unissued Common Stock and will, upon issue, be duly and
                      validly issued and fully paid and non-assessable and free
                      of any preemptive rights.

        Notwithstanding any other provision of this Security, the Company shall,
if the holder so elects, deliver any shares of Common Stock issuable pursuant to
this Section 2 to any third party designated in writing by the holder.

                      (e) In addition to any other rights available to the
               Purchaser, if the Company defaults in its obligation to deliver
               to the Purchaser the Convertible Notes (or shares of Common Stock
               in lieu thereof) required to be delivered to it pursuant to this
               Section 2, the Company shall pay the Purchaser, upon the
               Purchaser's demand, as liquidated damages by cash or wire
               transfer in immediately available funds to the account of the
               Purchaser, or as otherwise directed by the Purchaser, an amount
               determined pursuant to the following formula:

                                   [* * * *]

        In all respects not inconsistent with the terms and provisions of this
Amendment, the Option Agreement shall continue to be in full force and effect in
accordance with the terms and conditions thereof, and is hereby ratified,
adopted approved and confirmed. From and after the date hereof, each reference
to the Option Agreement in any other instrument or document shall be deemed a
reference to the Option Agreement as amended hereby, unless the context
otherwise requires.

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CONFIDENTIAL TREATMENT - EDITED COPY

        This Amendment may be executed by the parties hereto in any number of
counterparts, each of which shall be deemed to be an original, but all such
respective counterparts shall together constitute one and the same instrument.

                                   Very truly yours,

                                   SciClone Pharmaceuticals, Inc.

                                   By:
                                          --------------------------------------
                                   Name:  Donald R. Sellers
                                   Title: President and Chief Executive Officer

Accepted as of the date hereof:

UBS AG, London Branch

By:
       -----------------------------
Name:
Title:

By:
       -----------------------------
Name:
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                                                                   EXHIBIT 10.16

SECOND AMENDMENT OF EMPLOYMENT AGREEMENT

        This Second Amendment of Employment Agreement (this "Amendment") is
entered into as of December 2, 2000 by and between SciClone Pharmaceuticals,
Inc. (the "Company") and Donald R. Sellers (the "Employee").

        WHEREAS, the Company and Employee entered into that certain Employment
Agreement dated February 1, 1996 (the "Original Agreement"), which was
subsequently amended pursuant to the Amendment of Employment Agreement (the
"First Amendment")(the Original Agreement and the First Amendment collectively
referred to as the "Agreement").

        WHEREAS, the Company and Employee desire to further amend the Agreement
to (a) extend the termination date of the Agreement as set forth in Paragraph
4.1 of the Agreement and (b) increase the base salary of Employee as set forth
in Paragraph 3.1 of the Agreement.

        NOW, THEREFORE, the Company and Employee agree that:

        1.      The date "November 30, 1998" in Paragraph 4.1 is amended to
                "November 30, 2001."

        2.      The first sentence of Paragraph 3.1 is amended in its entirety
                to read as set forth below:

                The Company agrees to pay Employee a base salary of $400,000;
                provided, however, that Employee has been awarded a salary
                increase to be commenced at his discretion. Employee has advised
                the Company that the new salary will be effective January 1,
                2001. Therefore, the Company shall pay Employee a base salary of
                $432,000 (the "New Salary") effective as of that date.

        3.      All other terms, conditions and restrictions contained in the
                Agreement shall continue in full force and effect.

        Pursuant to Section 6.5 of the Agreement, this Amendment when fully
executed and delivered shall constitute an amendment thereto.

                   [REMAINDER OF PAGE INTENTIONALY LEFT BLANK]

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        IN WITNESS WHEREOF, the parties hereto have executed this Second
Amendment of Employment Agreement as of the day and year first above written.

                                           "COMPANY"
                                           SCICLONE PHARMACEUTICALS, INC.

                                           By
                                             ---------------------------

                                           Its
                                              --------------------------

                                           "EMPLOYEE"

                                           -----------------------------
                                           Donald R. Sellers

                       [SIGNATURE PAGE TO SECOND AMENDMENT
                            OF EMPLOYMENT AGREEMENT]

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