Document:

EX-10.47

EXHIBIT 10.47

DEUTSCHE BANK AG, CAYMAN ISLANDS BRANCH

60 Wall Street

New York, NY 10005

c/o Private Wealth Management

280 Park Avenue

NYC 03-0434

New York, NY 10017

Attention: Lending/ Edward F. Kane, Managing Director

October 27, 2008

BioMimetic Therapeutics, Inc.

389-A Nichol Mill Lane

Franklin, TN

Attention: Larry Bullock, CFO

Thank you for the fully executed Time Promissory Note of BioMimetic and the executed signature
pages of BioMimetic on the Pledge Agreement and the Securities Account Control Agreement (the
“SACA”). The Note has been accepted by the Bank and the Bank will be bound by its obligations as
set forth in the Note (including, subject to terms and conditions thereof, those to make advances
to BioMimetic from time to time).

Enclosed are the Bank’s executed signature pages for the Pledge Agreement and the SACA. The Bank is
in the process of obtaining an executed signature page for the SACA from DB Securities.

	 	 	 	 	 
	 	Very truly yours,

Deutsche Bank AG, Cayman Islands Branch

 	 
	 	By:  	/s/ Ned Kane
 	 
	 	 	Name:  	 	 
	 	 	Title:  		 
	 
	 	 	 
	 	By:  	/s/ William M. Crane
 	 
	 	 	Name:  	William M. Crane 	 
	 	 	Title:  	DirectorEX-10.48

EXHIBIT 10.48

SECOND AMENDMENT TO LEASE AGREEMENT

     THIS SECOND AMENDMENT TO LEASE AGREEMENT (“Second Amendment”) is made and entered into this
9th day of January, 2009, by and between NOBLEGENE DEVELOPMENT, LLC, a Tennessee limited liability
company (“Landlord”) and BIOMIMETIC THERAPEUTICS, INC., a Delaware corporation (“Tenant”).

R E C I T A L S:

     WHEREAS, Landlord has leased to the Tenant certain premises in the CSLSC Building C (“Building
C”) as more particularly described in that certain Lease Agreement dated August 17, 2007 between
Landlord and Tenant (the “Building C Lease”);

     WHEREAS, Landlord has incurred additional costs in the shell design and construction of
Building C due to Tenant’s requested changes to the shell of Building C (see Schedule “A”); and

     WHEREAS, Landlord and Tenant have mutually agreed to amend the Lease as set forth herein to
compensate Landlord for its additional costs.

     NOW, THEREFORE, for good and valuable consideration, the receipt and sufficiency of which is
hereby acknowledged, Landlord and Tenant do hereby covenant and agree as follows:

	1.	 	Amendment.     Section 3.1 of the Lease is deleted in its entirety and replaced with the
following language:

	 	 	 “3.1 Base Rent.     Tenant shall pay to Landlord, without notice or demand, in lawful
money of the United States of America, at Landlord’s address set forth herein or at
such other place or to such other person, firm or corporation as Landlord, from time
to time, may designate in writing, Base Rent for each Lease Year during the Term of
this Lease in an annual amount equal to $26.00 multiplied by the
Thirty-Thousand (30,000) rentable square feet within the Leased Premises, and such
amount shall be adjusted from time to time under the terms of this Lease. The
annual Base Rent, which for the first Lease year shall be Seven Hundred and
Eighty Thousand and 00/100 Dollars ($780,000.00), shall be due and payable in
twelve (12) equal monthly installments in the amount of Sixty Five Thousand and
00/100 Dollars ($65,000.00) each, payable in advance, beginning on the
Commencement Date and continuing on the first day of each successive calendar month
thereafter during the Term of this Lease. If any payment of Rent owing by Tenant to
Landlord after the Commencement Date
shall not be paid within five (5) days of the date when due, such unpaid amount
shall be considered delinquent, and shall (i) be assessed a late fee in the amount
of five percent (5%) of the unpaid amount, and (ii) bear interest at the Overdue
Rate from the date such Rent payment was due to the date of actual payment.”

1

 

	 	 	 The remaining provisions of the Lease Agreement shall remain in full force and effect.

	2.	 	Additional Consideration.     Within thirty (30) days of the execution of this Second
Amendment, Tenant shall pay Landlord, Two Hundred Thousand and 00/100 Dollars ($200,000.00).

	3.	 	Acknowledgements.     Upon execution of this Second Amendment, and payment of the
additional consideration set forth above, Landlord acknowledges that the entire amount of
additional costs for shell design and construction costs shall be satisfied and paid in full.
Landlord further acknowledges that the Tenant shall have no additional obligation to Landlord
for shell design and construction costs.

     IN WITNESS WHEREOF, the parties have executed this Second Amendment to Lease Agreement as of
the day and date first above written.

	 	 	 	 	 
	 	LANDLORD:	 
	 	 	 
	 	NOBLEGENE DEVELOPMENT, LLC,
 a
Tennessee limited liability company

 	 
	 
	 	By:  	/s/ John N. Weckesser
 	 
	 	 	 	 
	 
	 	Its:  	Chief Operations Manager	 
	 	 	 
	 	 	 
	 	 	 
	 
	 	TENANT:
	 
	 	BIOMIMETIC THERAPEUTICS, INC.,
 a
Delaware corporation

 	 
	 
	 	By:  	/s/ Larry Bullock
 	 
	 	 	 	 
	 
	 	Its:  	Chief Financial Officer	 
	 	 	 
	 	 	 
	 	 	 

2

 

SCHEDULE A — TENANT DIRECTED SHELL BUILDING C COSTS

	 	 	 
	Additional design costs from Centric Architecture are

	 	$221,776.00
	Additional costs from Central Concrete Placement are

	 	$112,751.00
	Completed and paid cost by Landlord total

	 	$334,527.00

	 	 	 
	Additional cost of structural steel (difference
of estimates, one without raised roof and one with
raised roof area)

	 	$69,000.00
	Siding, insulation, miscellaneous flashing, etc

	 	$3,000.00
	Total estimated cost for steel is

	 	$72,000.00

$406,527.00 as of December 3rd 2008 is the combined total cost to Tenant until
substantial completion if paid now.

Landlord eliminated mark-up and direct cost from the WL Group with expectations it will hasten a
quick turnaround.

Landlord acknowledges all shell cost from attributable to Tenants new shell requirements are paid
in full and that there will be no additional shell cost from Landlord. Tenant will have no further
obligation to the shell until “substantial completion” is reached or until such time “Tenant
Improvements” commence, whichever is the earlier.

3EX-10.1

Exhibit 10.1

GENTA INCORPORATED

PURCHASE AGREEMENT AND NOTE AMENDMENT

     This Purchase Agreement and Note Amendment (the “Amendment”) is made and entered
into as of February ___, 2009 by and among Genta Incorporated, a Delaware corporation (the
“Company”), and the Purchasers listed on the Schedule of Purchasers attached hereto as
Exhibit A (each, a “Purchaser” and collectively, the “Purchasers”).
This Amendment amends that certain Securities Purchase Agreement, dated as of June 5,
2008, by and among the Company and the purchasers named therein (the “Purchase Agreement”),
and each of the Senior Secured Convertible Promissory Notes due June 9, 2010 (the “Notes”)
issued pursuant to the Purchase Agreement. Capitalized terms used but not defined herein shall
have the meanings ascribed to such terms in the Purchase Agreement.

     Whereas, the Company desires to raise additional capital in an equity or debt financing in
order to continue its operations;

     Whereas, it is in the best interest of the Purchasers that the Company be able to raise
such capital and continue its operations;

     Whereas, the Purchase Agreement and Notes contain certain terms, the presence of which has
made and may continue to make raising additional capital difficult; and

     Whereas, the Purchasers and the Company, in order to maximize the Company’s ability to
raise additional capital, desire to amend the Purchase Agreement and the Notes as set forth herein.

     Now, Therefore, in consideration of the premises and mutual covenants herein below, and
for other good and valuable consideration, the receipt and sufficiency of which are hereby
acknowledged, the parties agree as follows:

1. Amendment of the Purchase Agreement.

     1.1 The parties hereby delete Section 1.2(b) of the Purchase Agreement in its entirety.

     1.2 The parties hereby amend and restate Section 1.3 of the Purchase Agreement as follows:

     “1.3 Conversion Shares. The Company has authorized and has reserved
and covenants to continue to reserve, free of preemptive rights and other similar
contractual rights of stockholders a total of 4,000,000,000 shares of Common Stock
to effect the conversion of the Notes and any interest accrued and outstanding
thereon. Within 75 days of the First Closing Date, the Company shall amend its
Certificate (as defined below) to increase the number of authorized shares of Common
Stock (the date of the effectiveness of such amendment, the “Amendment
Date”); provided that the foregoing deadline shall be 120 days if the SEC (as
defined below) reviews the Company’s proxy statement related to the approval of the
amendment. On and after the Amendment Date, the Company shall reserve (and hereby
covenants to continue to reserve), free of preemptive rights and other similar
contractual rights, a number of its authorized but unissued shares of Common Stock
equal to 125% of the aggregate number of shares of Common Stock issuable upon
conversion of or otherwise in respect of the Notes; provided that in the event the
Company shall consummate a Follow-On Offering (defined

 

 

below) the foregoing requirement shall be 100% during the three month period
following the closing of such Follow-On Offering. Any shares of Common Stock
issuable upon conversion or otherwise in respect of the Notes are herein referred to
as the “Conversion Shares”. The Notes and the Conversion Shares are
sometimes collectively referred to herein as the “Securities”. A
“Follow-On Offering” shall mean the sale of up to $23,000,000 of equity
and/or debt securities pursuant to that certain Registration Statement on Form S-1
(Registration No. 333-153278) originally filed on August 29, 2008 with Securities
and Exchange Commission provided that such offering is consummated on or prior to
March 30, 2009 and approved by the holders of 2/3 of the outstanding principal
amount of the Notes.”

2. Amendment of the Notes.

     2.1 The parties hereby amend the term “Purchase Agreement” in each Note to mean the Purchase
Agreement as amended on the date hereof.

     2.2 The parties hereby amend and restate Section 2.1(g) of each Note as follows:

     “(g) at any time following the Amendment Date the Maker shall fail to have a
sufficient number of shares of Common Stock authorized, reserved and available for
issuance to satisfy the potential conversion in full (disregarding for this purpose
any and all limitations of any kind other than as set forth in Section 3.1(a) on
such conversion) of this Note and each Other Note; or”

     2.3 The parties hereby amend and restate Section 3.1(a) of each Note as follows:

     “(a) Voluntary Conversion. At any time and from time to time on or
after the Amendment Date, this Note shall be convertible (in whole or in part), at
the option of the Holder, into such number of fully paid and non-assessable shares
of Common Stock as is determined by dividing (x) that portion of the outstanding
principal balance that the Holder elects to convert by (y) the Conversion Price (as
defined in Section 3.2 hereof) then in effect on the date on which the Holder faxes
a notice of conversion (the “Conversion Notice”), duly executed, to the
Maker (facsimile number (908) 464-1705, Attn.: Raymond P. Warrell, Jr., M.D.) (the
“Voluntary Conversion Date”); provided that during the three month period
following the closing of the Follow-On Offering, if any, the conversion of this Note
shall be limited to the Holder’s Pro Rata Conversion Amount. For purposes of this
Note, the Holder’s “Pro Rata Conversion Amount” shall mean the principal
amount of the Note that may be converted into that number of shares of Common Stock
at the Conversion Price then in effect, determined as follows:

X = Y * (A/B)

where

	 
	 	X =	the number of shares of Common Stock that may be
issued upon conversion of the Note
	 
	 	Y =	the total number of shares of Common Stock then
authorized, unissued and available for issuance
	 
	 	A =	the outstanding principal amount of the Note

 

 

	 	B =	the aggregate outstanding principal amount of all
outstanding Notes and Other Notes

     The Holder shall deliver this Note to the Maker at the address designated in
the Purchase Agreement at such time that this Note is fully converted. With respect
to partial conversions of this Note, the Maker shall keep written records of the
amount of this Note converted as of each Conversion Date. On any such Voluntary
Conversion Date, Maker shall also pay Holder an amount in cash equal to the then
accrued and unpaid interest on the portion of the outstanding principal balance that
the Holder has elected to convert.”

     2.4 The parties hereby amend and restate the first sentence of Section 3.5(h) of each Note as
follows:

     “(h) Reservation of Common Stock. On and after the Amendment Date (as
defined in the Purchase Agreement), the Maker shall at all times when this Note
shall be outstanding, reserve and keep available out of its authorized but unissued
Common Stock, such number of shares of Common Stock as shall from time to time be
sufficient to effect the conversion of this Note; provided that the number of shares
of Common Stock so reserved shall at no time be after the Amendment Date less than
one hundred twenty five percent (125%), or one hundred percent (100%) during the
three month period following the closing of the Follow-On Offering, if any, of the
number of shares of Common Stock for which this Note is at any time convertible
(disregarding for this purpose any and all limitations of any kind on such
conversion).”

     2.5 The parties hereby amend and restate Section 5.13(g) of each Note as follows:

     “(g) “Permitted Lien” means the individual and collective reference to
the following: (a) Liens for taxes, assessments and other governmental charges or
levies not yet due or Liens for taxes, assessments and other governmental charges or
levies being contested in good faith and by appropriate proceedings for which
adequate reserves (in the good faith judgment of the management of the Maker) have
been established in accordance with GAAP; (b) Liens imposed by law which were
incurred in the ordinary course of the Maker’s business, such as carriers’,
warehousemen’s and mechanics’ Liens, statutory landlords’ Liens, and other similar
Liens arising in the ordinary course of the Maker’s business, and which (x) do not
individually or in the aggregate materially detract from the value of such property
or assets or materially impair the use thereof in the operation of the business of
the Maker and its consolidated subsidiaries or (y) are being contested in good faith
by appropriate proceedings, which proceedings have the effect of preventing for the
foreseeable future the forfeiture or sale of the property or asset subject to such
Lien; (c) encumbrances consisting of licenses of the Grantors’ intellectual property
that are created in connection with joint ventures, collaborations, or partnership
activities of Grantors and are approved in advance in writing by the holders of 55%
of the then outstanding principal amount of the Notes; and (d) security interests
granted in connection with any equity or debt financing approved by the holders of
2/3 of the outstanding principal amount of the Notes.”

3. Miscellaneous.

     3.1 Governing Law. This Amendment shall be governed by and construed in accordance
with the internal laws of the State of New York, without giving effect to any of the conflicts of
law principles which would result in the application of the substantive law of another
jurisdiction. This

 

 

Amendment shall not be interpreted or construed with any presumption against the
party causing this Agreement to be drafted.

     3.2 Full Force and Effect. Except as expressly amended by this Amendment, the terms
and conditions of the Purchase Agreement and the Notes remain in full force and effect.

     3.3 Conflict of Terms. In the event of a conflict between this Amendment and any
provision of any of the Purchase Agreement or the Notes, the terms of this Amendment shall control.

     3.4 Counterparts; Effectiveness. This Amendment may be executed in any number of
counterparts, all of which taken together shall constitute one and the same instrument. The
provisions of Sections 1 and 3 hereof shall become effective immediately when counterpart signature
pages to this Amendment have been executed and delivered to the Company by (w) the Company and (x)
holders of at least 2/3 of the principal amount of the outstanding Notes and delivered to the
Company. The provisions of Section 2 hereof shall become effective immediately when counterpart
signature pages to this Amendment have been executed and delivered to the Company by (y) the
Company and (z) holders of all outstanding Notes. All parties need not sign the same counterpart
signature page. Execution by facsimile shall have the same effect as an original signature.

[REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK]

 

 

     In Witness Whereof, the parties hereto have executed this Purchase Agreement and Note
Amendment as of the date set forth in the first paragraph hereof.

	 	 	 	 	 
	 	GENTA INCORPORATED

 	 
	 	By:  	/s/ Raymond P. Warrell
 	 
	 	 	Name:  	Raymond P. Warrell, Jr., M.D. 	 
	 	 	Title:  	Chairman and Chief Executive Officer 	 
	 

[SIGNATURE PAGES CONTINUE]

[Signature Page Purchase Agreement and Note Amendment]

 

 

[HOLDER SIGNATURE PAGES TO PURCHASE AGREEMENT AND NOTE AMENDMENT]

     IN WITNESS WHEREOF, the undersigned have caused this Purchase Agreement and Note Amendment to
be duly executed by their respective authorized signatories as of the date first indicated above.

Name of Holder:
          
          
          
          
          
          

     
             
             
             
               
     

Signature of Authorized Signatory of Holder: 
          
          
          
          
          
    

             
               
     

Name of Authorized Signatory:
          
          
          
          
          
          
             
             
             
               
     

Title of Authorized Signatory:
          
          
          
          
          
          
             
             
             
               
     

[SIGNATURE PAGES CONTINUE]

[Signature Page to Purchase Agreement and Note Amendment]

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