Document:

EX-10.8

 Exhibit 10.8 
 AMENDMENT NUMBER TWO to be attached to and form a part of the Lease (which together with any amendments, modifications and extensions hereto are hereinafter called the Lease), made the 18th day
of February, 1992: 
  

			
	Between:	  	Spieker Properties, L.P., a California Limited Partnership
		  	(Successor in interest to Spieker-Singleton #87, A Limited Partnership)
		
		  	As Landlord
		
	And:	  	Transplantation Technology, Inc., a Delaware Corporation and
		  	Metabolex, Inc., a California Corporation
		
		  	As Tenant

  

			
	Covering the Premises known as:	 	 3872-3876 Bay Center Place
 Hayward, California

 The Lease is hereby amended on condition that Landlord and Tenant comply with all the provisions of the covenants and
agreements contained in the Lease, including the following which hereby serve to amend the Lease: 
  

							
	1.	  	Tenant Name:	  	As a result of Tenant’s change in corporate status, Tenant shall hereinafter be referred to as Metabolex, Inc., a Delaware Corporation.
			
	2.	  	Renewal Term:	  	Effective May 1, 1997, the lease term shall be extended an additional three (3) years, and shall expire on April 30, 2000.
			
	3.	  	Base Rent:	  	Effective May 1, 1997, Base Rent for the Existing Premises is provided below;

  

									
	 Months 1-12
	  	$	11,319 per month	  	  	($	.88/sf/mo.	) 
	 Months 13-24
	  	$	11,576 per month	  	  	($	.90/sf/mo.	) 
	 Months 25-36
	  	$	11,833 per month	  	  	($	.92/sf/mo.	) 

  

							
	4.	  	 Tenant

Improvements:
	  	Landlord, at Landlord’s sole cost and expense, shall make the following improvements:
				
		  		  	•	  	Replace existing carpet in the office area with new 26 ounce level-loop carpet (approximately 425 yards).
				
		  		  	•	  	Replace damaged VCT floor covering in the lab and corridor areas (approximately 328 square feet).
				
		  		  	•	  	Replace stained ceiling tiles.
				
		  		  	•	  	Replace and/or clean light diffusers.
			
	5.	  	Prior Right of Refusal:	  	  
 Provided Tenant is not, and has not been, in
default of any terms or conditions under the Lease, Tenant shall have a prior right of refusal to lease any or all vacant space adjacent to the Premises, such space more commonly known as 3868 & 3880 Bay Center Place. Upon notification by
Landlord either orally or in writing of the availability of space. Tenant shall have five (5) days to notify Landlord of Tenant’s desire to exercise Tenant’s prior right of refusal on the terms and conditions offered by Landlord. In the
event Tenant fails to give Landlord notice of Tenant’s election to lease the adjoining space within the time period, Tenant shall have no further right, title or interest in the adjacent space and the prior right of refusal shall terminate. If,
on the other hand, Tenant exercises its prior right of refusal in the manner prescribed, Tenant shall immediately deliver to Landlord payment for the first month’s rent for the adjacent space (in the same manner as provided for in the Lease),
and the lease for the adjacent space shall be consummated without delay in accordance with the terms and conditions set forth in the lease offer.

					
	6.	  	 Renewal

Option:
	  	  
 Provided Tenant is not, and has not been, in default of its
obligations under the Lease. Tenant shall have an option to release the premises in “as in” condition for a term of two (2) years at fair market rent for space with a comparably equipped lab. In no event will the monthly rental be less
than the rental for the last month of the previous term. Tenant shall give Landlord written notice of its intent to exercise its option at least one hundred eighty (180) days prior to the expiration of the current lease term. At least fifteen (15)
days prior to that date. Landlord will have provided Tenant with terms and conditions including rent for the renewal period.

 IN WITNESS WHEREOF, the parties hereto have signed and sealed this Amendment this 20 day of November 1996.

  

			
	“LANDLORD”
	
	 SPIEKER PROPERTIES, L.P.
 A CALIFORNIA LIMITED PARTNERSHIP

		
	By:	 	Spieker Properties, Inc.
		 	a Maryland Corporation
		
	Its:	 	General Partner
		
	BY	 	Peter H. Schnugg 
	 Peter H. Schnugg

Senior Vice President

	
	“TENANT”
	
	 METABOLEX, INC.
 A DELAWARE CORPORATION

		
	By: 	 	Thomas A. Glaze
		
	Its:	 	PRESIDENT

			
		
	Print Name:	 	THOMAS A. GLAZE

			
		
	Date:	 	NOVEMBER 8, 1996EX-10.9

 Exhibit 10.9 
 AMENDMENT NUMBER THREE to be attached to and form a part of the Lease (which together with any amendments, modifications and extensions hereto are hereinafter called the Lease), made the 18th
day of February, 1992: 
  

			
	Between:	  	 Spieker Properties, L.P., a California Limited Partnership
 (Successor in interest to Spieker-Singleton #87, A Limited Partnership)

		
		  	As Landlord
		
	And:	  	Metabolex, Inc., a Delaware Corporation
		
		  	As Tenant

  

			
	Covering the Premises known as:	  	 3872-3876 Bay Center Place
 Hayward, California

 The Lease is hereby amended on condition that Landlord and Tenant comply with all the provisions of the covenants and
agreements contained in the Lease, including the following which hereby serve to amend the Lease: 
  

													
	1.	 	Term:	 	Effective July 1, 1998, the lease term shall be extended an additional five (5) years, and shall expire on June 30, 2003.	   
			
	2.	 	Premises:	 	The Premises shall be expanded to include an additional 22,310 square feet, more commonly known as 3860 and 3868 Bay Center Place (“Expansion Premises”),
Collectively, the existing premises (“Existing Premises”), known as 3872 Bay Center Place, and the Expansion Premises will total approximately 35,172 square feet and shall be referred to as the Premises (see attached Exhibit
“A”).	     
			
	3.	 	Base Rent:	 	Effective July 1, 1998, Base Rent for the Existing Premises and Expansion Premises is provided below:	   
				
	 	 	 	  	Existing Premises	 	  	Expansion Premises	 
	 	Months 1 - 12	  	$	11,576 per month	  	  	$	12,047 per month	  
	 	Months 13 - 24	  	$	11,833 per month	  	  	$	12,494 per month	  
	 	Months 25 - 36	  	$	12,090 per month	  	  	$	12,940 per month	  
	 	Months 37 - 48	  	$	12,348 per month	  	  	$	13,386 per month	  
	 	Months 49 - 60	  	$	12,605 per month	  	  	$	13,832 per month	  
			
	4.	 	Estimated Basic Operating Cost:	 	Monthly first year Estimated Basic Operating Cost of $4,924 ($.14/sf/mo.)	  
			
	5.	 	 Tenant

Improvements:
	 	  
  
 Landlord, at its sole cost and expense, will provide a tenant improvement allowance of $45,000 for Tenant’s refurbishment (the “Refurbishment”) of the Expansion Premises, The Refurbishment
shall reasonably conform to the approved space plan, attached as Exhibit “B”. Subject to Paragraph 12 of Tenant’s original Lease, Tenant will not be required to restore the Premises upon expiration of the Lease.
	 
 

      

			
	6.	 	Occupancy Density:	 	The occupancy density for the Premises shall increase from fifty (50) to one hundred (100) people.	  
			
	7.	 	Parking:	 	Tenant shall be entitled to Tenant’s Proportionate Share of the parking spaces for the Building.	  
			
	8.	 	Security Deposit:	 	The Security Deposit for the Premises shall increase from twelve thousand ($12,000) dollars to twenty eight thousand ($28,000) dollars.	   
			
	9.	 	Warranty:	 	Landlord shall warrant the Expansion Premises, including but not limited to the HVAC, electrical and plumbing systems, for a period of thirty (30) days following the
Tenant’s occupancy of the Expansion Premises, provided any malfunction is not due to Tenant’s failure to comply with the Lease and/or due to Tenant’s failure to properly maintain the Expansion Premises.	     

					
	10.	 	Tenant’s Proportionate Share:	 	  
  
 84.55% of Building
 27.33% of Project

			
	11.	 	 Prior Right
 of
Refusal:
	 	  
  
 Provided Tenant is not, and has not been, in default of any terms or conditions under the Lease, Tenant shall have a prior right of refusal to lease any or all vacant space adjacent to the Premises, such
space more commonly known as 3880 Bay Center Place. Upon notification by Landlord either orally or in writing of the availability of space, Tenant shall have five (5) days to notify Landlord of Tenant’s desire to exercise Tenant’s prior
right of refusal on the terms and conditions offered by Landlord. In the event Tenant fails to give Landlord notice of Tenant’s election to lease the adjoining space within the time period, Tenant shall have no further right, title or interest
in the adjacent space and the prior right of refusal shall terminate. If, on the other hand, Tenant exercises its prior right of refusal in the manner prescribed. Tenant shall immediately deliver to Landlord payment for the first month’s rent
for the adjacent space (in the same manner as provided for in the Lease), and the lease for the adjacent space shall be consummated without delay in accordance with the terms and conditions set forth in the lease offer.

			
	12.	 	 Renewal

Option:
	 	  
  
 Provided Tenant is not, and has not been, in default of its obligations under the Lease, Tenant shall have an option to release the premises in “as is” condition for a term of three (3) years at
fair market rent for space with a comparably equipped lab. In no event will the monthly rental be less than the rental for the last month of the previous term. Tenant shall give Landlord written notice of its intent to exercise its option at least
one hundred eighty (180) days prior to the expiration of the current lease term.

 IN WITNESS WHEREOF, the parties hereto have signed and sealed this Amendment this 27 day of May 1998. 

 

			
	“LANDLORD”
	
	 SPIEKER PROPERTIES, L.P.
 A CALIFORNIA LIMITED PARTNERSHIP

		
	By:	 	 Spieker Properties, Inc.
 a
Maryland Corporation

		
	Its:	 	General Partner
		
	BY:	 	/s/ Peter H. Schnugg
		 	Peter H. Schnugg
		 	Senior Vice President
	
	“TENANT”
	
	 METABOLEX, INC.
 A DELAWARE CORPORATION

		
	By:	 	/s/ David Pritchard
		
	Its:	 	Vice President & CFO

			
		
	Print Name:	 	David Pritchard

			
		
	Date:	 	May 6, 1998

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00220-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00220-of-00352.parquet"}]]