Document:

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                                                                   Exhibit 10.74

                          REGISTRATION RIGHTS AGREEMENT

        This REGISTRATION RIGHTS AGREEMENT (this "AGREEMENT"), dated as of
January 31, 2006, is by and between VYTERIS HOLDINGS (NEVADA), INC., a Nevada
corporation (the "COMPANY"), and SPENCER TRASK SPECIALTY GROUP, LLC, a Delaware
limited liability company (the "INVESTOR").

        The Company has agreed, on the terms and subject to the conditions set
forth in the Note and Warrant Purchase Agreement, dated as of January 31, 2006
(the "NOTE AND WARRANT AGREEMENT"), to issue and sell to the Investor named
therein (A) the Note in the form attached to the Note and Warrant Agreement (the
"NOTE") and (B) the Warrants in the forms attached to the Note and Warrant
Agreement (the "WARRANTS").

        The Note is convertible into shares (the "CONVERSION SHARES") of the
Company's common stock, par value $0.001 per share (the "COMMON STOCK"). The
Warrants are exercisable into shares of Common Stock (the "WARRANT SHARES;" and
collectively with the Conversion Shares, the "REGISTRABLE SECURITIES") in
accordance with their terms.

        In order to induce the Investor to enter into the Note and Warrant
Agreement, the Company has agreed to provide certain registration rights under
the Securities Act of 1933, as amended (the "SECURITIES ACT"), and under
applicable state securities laws.

        In consideration of the Investor entering into the Note and Warrant
Agreement, and other good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, the parties agree as follows:

        1.      PIGGYBACK REGISTRATION STATEMENT. If, at any time, the Company
proposes to file any registration statement on Form S-1 or such other
appropriate form in accordance with the Securities Act of 1933, as amended (the
"Securities Act") for purposes of a public offering of securities of the Company
(including, but not limited to, registration statements relating to secondary
offerings of securities of the Company, but excluding registration statements
relating to employee benefit plans or with respect to corporate reorganizations
or other transactions under Rule 145 of the Securities Act or initial public
offerings) it will give written notice by facsimile or mail, at least five (5)
days prior to the filing of each registration statement, to the Investor of its
intention to do so. If the Investor notifies the Company within five (5) days
after receipt of any such notice of its desire to include any such securities in
such proposed registration statement, the Company shall afford the Investor the
opportunity to have any Registrable Securities registered under such
registration statement.

        2.      OBLIGATIONS OF THE COMPANY. In connection with the filing of any
registration statement herein, the Company shall:

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                2.1     Prepare and file with the Securities and Exchange
Commission (the "SEC") such amendments and supplements to such registration
statement and the prospectus used in connection with such registration statement
as may be necessary to comply with the provisions of the Securities Act with
respect to the disposition of all securities covered by such registration
statement.

                2.2     Furnish to the Investor such numbers of copies of a
prospectus, including a preliminary prospectus, in conformity with the
requirements of the Securities Act, and such other documents as they may
reasonably request in order to facilitate the disposition of Registrable
Securities owned by them.

                2.3     Use its best efforts to register and qualify the
securities covered by such registration statement under such other securities or
"blue sky" laws of such jurisdictions as shall be reasonably requested by the
Investor; PROVIDED, HOWEVER, that the Company shall not be required in
connection therewith or as a condition thereto to qualify to do business or to
file a general consent to service of process in any such states or
jurisdictions.

                2.4     Notify the Investor at any time when a prospectus
relating thereto is required to be delivered under the Securities Act of the
happening of any event as a result of which the prospectus included in such
registration statement, as then in effect, includes an untrue statement of a
material fact or omits to state a material fact required to be stated therein or
necessary to make the statements therein not misleading in the light of the
circumstances then existing.

                2.5     Use its best efforts to cause all Registrable Securities
covered by such registration statement to be listed on each securities exchange
on which similar securities listed by the Company are then listed.

        3.      OBLIGATIONS OF THE INVESTOR.

                The Investor shall furnish to the Company such information
regarding the Investor, the number of Registrable Securities owned and proposed
to be sold by it, the intended method of disposition of such securities and any
other information as shall be required to effect the registration of the
Investor's Registrable Securities, and cooperate with the Company in preparing
the registration statement and in complying with the requirements of the
Securities Act.

        4.      REGISTRATION EXPENSES.

                The Company shall bear and pay all expenses incurred in
connection with any registration, filing or qualification of Registrable
Securities, including without limitation all registration, listing, filing and
qualification fees, printers and accounting fees, but excluding (i) underwriting
discounts and commissions relating to the Registrable Securities and (ii) legal
fees and disbursements of any and all counsel retained by the Investor.

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        5.      SUSPENSION OF EFFECTIVENESS.

If the Company shall furnish to the Investor a certificate signed by the
President or Chief Executive Officer of the Company stating that, in the good
faith judgment of the Board of Directors of the Company, it is necessary to
suspend the effectiveness of any registration statement filed hereunder, the
Company shall have the right, exercisable two (2) times only in any consecutive
twelve (12) month period, to suspend the effectiveness of the registration
statement with respect to such offering for a period of not more than an
aggregate of ninety (90) days per suspension.

        6.      INDEMNIFICATION.

                6.1     To the extent permitted by law, the Company will
indemnify the Investor, its members, directors, officers, shareholders,
employees, agents and affiliates, legal counsel for the Investor, and each
person controlling the Investor within the meaning of the Securities Act, with
respect to which registration, qualification or compliance of Registrable
Securities has been effected pursuant to this Agreement, against any losses,
claims, damages, liabilities or actions in respect thereof (collectively,
"Damages"), arising out of or based on any untrue statement or alleged untrue
statement of a material fact contained in a Registration Statement filed
pursuant hereto, prospectus offering circular or other document, or any omission
or alleged omission to state therein a material fact required to be stated
therein or necessary to make the statements therein not misleading, or any
violation or alleged violation by the Company of the Securities Act, the
Securities Exchange Act of 1934, as amended (the "Exchange Act"), or any state
securities laws or any rule or regulation promulgated under such laws and
relating to action or inaction required of the Company in connection with any
such registration, qualification or compliance; and the Company will pay each
the Investor any legal and other expenses reasonably incurred by them in
connection with investigating or defending any such claim, loss, damage,
liability or action; provided, however, that the indemnity contained in this
Section 6.1 shall not apply to: (i) amounts paid in settlement of any such
Damages if settlement is effected without the consent of the Company (which
consent shall not unreasonably be withheld); (ii) any such Damages arising out
of or a based upon any untrue statement or omission based upon information
furnished to the Company by the Investor and stated to be for use in connection
with the offering of securities of the Company; or (iii) any such Damages
arising out of or based upon the Investor's failure to deliver a copy of the
registration statement or prospectus or any amendments or supplements thereto.

                6.2     To the extent permitted by law, the Investor will, if
Registrable Securities held by the Investor are included in the securities as to
which such registration, qualification or compliance is being effected pursuant
to this Agreement, indemnify the Company, each of its directors, officers,
shareholders, employees, agents and affiliates, each legal counsel and
independent accountant of the Company, each person who controls the Company
within the meaning of the Securities Act, and each other the Investor, each of
its directors, officers, shareholders, employees, agents and affiliates, legal
counsel, and each person controlling such other Purchaser within the meaning of
the Securities Act, against all Damages arising out of or based upon arising any
untrue statement or alleged untrue statement of a material fact contained in a
registration statement filed pursuant hereto, prospectus offering circular or
other document, or any omission or alleged omission to state therein a material
fact required to be stated therein

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or necessary to make the statements therein not misleading, or any violation or
alleged violation by the Investor of the Securities Act, the Exchange Act, or
any state securities laws or any rule or regulation promulgated under such laws
and relating to action or inaction required of the Investor in connection with
any such registration, qualification or compliance; and the Investor will pay
the Company or such other Investor any legal and other expenses reasonably
incurred by them in connection with investigating or defending any such claim,
loss, damage, liability or action, in each case, to the extent, but only to the
extent, that such untrue statement or alleged untrue statement or omission or
alleged omission is made in such registration statement, prospectus, offering
circular or other document in reliance on and in conformity with information
furnished to the Company by the Investor and stated to be for use in connection
with the offering of securities of the Company; PROVIDED, HOWEVER, that the
indemnity contained in this Section 6.2 shall not apply to amounts paid in
settlement of any such Damages if settlement is effected without the consent of
the Investor (which consent shall not unreasonably be withheld).

                6.3     Promptly after receipt by an indemnified party under
this Section 6 of notice of the commencement of any action (including any
governmental action), such indemnified party will, if a claim in respect thereof
is to be made against any indemnifying party under this Section 6, deliver to
the indemnifying party a written notice of the commencement thereof and the
indemnifying party shall have the right to participate in, and, to the extent
the indemnifying party so chooses, jointly with any other indemnifying party
similarly noticed, to assume the defense thereof with counsel mutually
satisfactory to the parties; PROVIDED, HOWEVER, that an indemnified party shall
have the right to retain one separate counsel, with the reasonable fees and
expenses to be paid by the indemnifying party, if representation of such
indemnified party by the counsel retained by the indemnifying party would be
inappropriate due to actual or potential differing interests between such
indemnified party and any other party represented by such counsel in such
proceeding. The failure to deliver written notice to the indemnifying party
within a reasonable time of the commencement of any such action, if prejudicial
to its ability to defend such action, shall relieve such indemnifying party of
any liability to the indemnified party under this Section 6, but the omission to
so deliver written notice to the indemnifying party will not relieve it of any
liability that it may have to any indemnified party otherwise than under this
Section 6.

                6.4     If the indemnification provided for in this Section 6 is
held by a court of competent jurisdiction to be unavailable to an indemnified
party with respect to any loss, liability, claim, damage or expense referred to
therein, then the indemnifying party, in lieu of indemnifying such indemnified
party hereunder, shall contribute to the amount paid or payable by such
indemnified party as a result of such Damages in such proportion as is
appropriate to reflect the relative fault of the indemnifying party on the one
hand and of the indemnified party on the other in connection with the statements
or omissions that resulted in such Damages as well as any other relevant
equitable considerations. The relative fault of the indemnifying party and of
the indemnified party shall be determined by reference to, among other things,
whether the untrue or alleged untrue statement of a material fact or the
omission or alleged omission to state a material fact relates to information
supplied by the indemnifying party or by the indemnified party and the parties'
relative intent, knowledge, access to information and opportunity to correct or
prevent such statement or omission.

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                6.5     The obligations of the Company and the Investor under
this Section 6 shall survive the completion of any offering of Registrable
Securities pursuant to a registration statement under this Agreement.

        7.      NOTICES.

                7.1     Any notice or communication required or permitted
hereunder shall be given in writing and shall be made by hand delivery, by
confirmed facsimile, by overnight courier or by registered or certified mail,
addressed (i) if to the Investor, to the Investor's address as set forth on
Schedule A hereto, and (ii) if to the Company, to Vyteris Holdings (Nevada),
Inc., 13-01 Pollitt Drive, Fair Lawn, New Jersey 07410, Attention: Chief
Executive Officer, Facsimile: (201) 796-6057 with a copy to Lownestein Sandler
PC, 65 Livinston Avenue, Roseland, NJ 07068, facsimile number (973) 597-2400,
Attention: Peter H. Ehrenberg, Esq.

                7.2     All such notices and other communications shall be
deemed to have been delivered and received (i) in the case of personal delivery
or facsimile, on the date of such delivery, (ii) in the case of overnight
courier, on the business day after the date when sent, and (iii) in the case of
registered or certified mail, on the third business day following such mailing.

        8.      MISCELLANEOUS.

                8.1     This Agreement shall be governed by, and construed in
accordance with, the laws of the State of New York, without regard to the
principles of the conflict of laws thereof. The parties hereby irrevocably and
unconditionally consent to submit to the exclusive jurisdiction of the courts of
the State of New York located in New York County and any Federal court located
within New York County for any actions, suits or proceedings arising out of or
relating to this Agreement. The parties hereby irrevocably and unconditionally
waive any objection to the laying of venue of any action, suit or proceeding
arising out of this Agreement in the courts of the State of New York located in
New York County or the courts of the United States of America located in New
York County, and hereby further irrevocably and unconditionally waive and agree
not to plead or claim in any such court that any such action, suit of proceeding
brought in any such court has been brought in an inconvenient forum.

                8.2     Any term of this Agreement may be amended and the
observance of any term of this Agreement may be waived (either generally or in a
particular instance and either retroactively or prospectively), only with the
written consent of the Company and the Investor of a majority of the Registrable
Securities then outstanding. Any amendment or waiver effected in accordance with
this paragraph shall be binding upon the Investor of any Registrable Securities
then outstanding, each future Purchaser of all such Registrable Securities, and
the Company.

                8.3     Nothing in this Agreement, express or implied, is
intended to confer upon any party other than the parties hereto any rights,
remedies, obligations or liabilities under or by reason of this Agreement,
excepts as expressly provided herein.

                8.4     If one or more provisions of this Agreement are held to
be unenforceable under applicable law, such provision shall be excluded from
this Agreement and the balance of

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the Agreement shall be interpreted as if such provision were so excluded and
shall be enforceable in accordance with its terms.

                8.5     The headings of the Sections of this Agreement are for
convenience and shall not by themselves determine the interpretation of this
Agreement.

                8.6     This Agreement constitutes the entire contract among the
Company and the Investor relative to the subject matter hereof and supersedes in
its entirety any and all prior agreements, understandings and discussions with
respect thereto.

                8.7     The Agreement may be executed in two or more
counterparts, each of which shall be deemed an original, but all of which
together shall constitute one and the same instrument.

                   [BALANCE OF PAGE INTENTIONALLY LEFT BLANK]

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        IN WITNESS WHEREOF, the parties have executed this Agreement as of the
date first above written.

                                    SPENCER TRASK SPECIALTY GROUP, LLC

                                    By: /s/ Donald F. Farley
                                        Name: Donald F. Farley
                                        Title: Chief Executive Officer

                                    VYTERIS HOLDINGS (NEVADA), INC.

                                    By: /s/ Timothy J. McIntyre
                                        Name: Timothy J. McIntyre
                                        Title: President & Chief Executive
                                               Officer

                                    By: /s/ Michael McGuinness
                                        Name: Michael McGuinness
                                        Title: Chief Financial Officer

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                                                                   Exhibit 10.75

THE SECURITIES REPRESENTED HEREBY AND THE SECURITIES WHICH MAY BE ISSUED UPON
EXERCISE HEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS
AMENDED, OR ANY STATE SECURITIES OR BLUE SKY LAWS. NO SALE OR DISTRIBUTION
HEREOF OR THEREOF MAY BE EFFECTED WITHOUT AN EFFECTIVE REGISTRATION STATEMENT
RELATED THERETO OR AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE COMPANY
THAT SUCH REGISTRATION IS NOT REQUIRED UNDER APPLICABLE SECURITIES LAWS.

                                WARRANT AGREEMENT

        WARRANT AGREEMENT (this "Agreement"), dated as of January 31, 2006, by
and between Vyteris Holdings (Nevada), Inc., a Nevada corporation (the
"Company"), and Spencer Trask Specialty Group, LLC, a Delaware limited liability
company (the "Warrant Holder").

                               W I T N E S S E T H

        WHEREAS, the parties have entered into that certain Note and Warrant
Purchase Agreement, dated as of January 31, 2006, by and between the Company and
the Warrant Holder (the "Note and Warrant Purchase Agreement"); and

        WHEREAS, pursuant to the Note and Warrant Purchase Agreement, the
Warrant Holder has agreed to loan to the Company Two Hundred Fifty Thousand
($250,000) Dollars (the "Loan Amount"), subject to the issuance by the Company
of a convertible subordinated promissory note (the "Note"), and the Company has
agreed to issue to the Warrant Holder a warrant (the "Warrant") to purchase
52,083 shares of the Company's common stock, par value $.0001 per share (the
"Common Stock"), subject to the terms set forth herein.

        NOW, THEREFORE, in consideration of the foregoing and the mutual
covenants and promises contained herein, and for other good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, the
parties agree as follows:

        1.      WARRANT.

        1.1     COMMON STOCK. The Company hereby grants to the Warrant Holder,
subject to the terms set forth herein, the right to purchase at any time during
the term (the "Warrant Exercise Term") commencing on the date hereof and ending
at 5:30 p.m., New York time, on the seventh anniversary of the date hereof (the
"Expiration Date") 52,083 shares of Common Stock (the "Shares"), at an initial
exercise price of $2.88 per share, subject to adjustment as provided in Sections
1.2 and 3 hereof (as in effect from time to time, the "Exercise Price").

        2.      EXERCISE OF WARRANT.

                2.1     EXERCISE. The Warrant may be exercised by the Warrant
Holder, in whole or in part, by delivering the Notice of Exercise purchase form,
attached as EXHIBIT A hereto (the "Notice of Exercise"), duly executed by the
Warrant Holder to the Company at its principal office, or at such other office
as the Company may designate, accompanied by payment, in cash or by wire
transfer or check payable to the order of the Company, of the amount obtained by
multiplying the number of Shares designated in the Notice of Exercise by the
Exercise Price (the

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"Purchase Price"). The Purchase Price may also be paid, in whole or in part, by
delivery of such purchase form and of shares of Common Stock owned by the
Warrant Holder having a Fair Market Value (as defined in Section 2.3 hereof) on
the last business day ending the day immediately prior to the Exercise Date (as
defined below) equal to the portion of the aggregate Exercise Price being paid
in such shares. In addition, the Warrant may be exercised, pursuant to a
cashless exercise by providing irrevocable instructions to the Company, through
delivery of the Notice of Exercise with an appropriate reference to this Section
2.1 to issue the number of shares of the Common Stock equal to the product of
(a) the number of shares as to which the Warrant is being exercised multiplied
by (b) a fraction, the numerator of which is the Fair Market Value of a share of
the Common Stock on the last business day preceding the Exercise Date less the
Exercise Price therefor and the denominator of which is such Fair Market Value.
For purposes hereof, "Exercise Date" shall mean the date on which all deliveries
required to be made to the Company upon exercise of the Warrant pursuant to this
Section 2.1 shall have been made.

                2.2     ISSUANCE OF CERTIFICATES. As soon as practicable after
the exercise of the Warrant (in whole or in part) in accordance with Section 2.1
hereof, the Company, at its expense, shall cause to be issued in the name of and
delivered to the Warrant Holder (i) a certificate or certificates for the number
of fully paid and non-assessable Shares to which the Warrant Holder shall be
entitled upon such exercise and (if applicable) (ii) a new warrant agreement of
like tenor to purchase all of the Shares that may be purchased pursuant to the
portion, if any, of the Warrant not exercised by the Warrant Holder. The Warrant
Holder shall for all purposes be deemed to have become the holder of record of
such Shares on the date on which the Notice of Exercise and payment of the
Purchase Price in accordance with Section 2.1 hereof were delivered and made,
respectively, irrespective of the date of delivery of such certificate or
certificates, except that if the date of such delivery, notice and payment is a
date when the stock transfer books of the Company are closed, such person shall
be deemed to have become the holder of record of such Shares at the close of
business on the next succeeding date on which the stock transfer books are open.

                2.3     FAIR MARKET VALUE. The "Fair Market Value" of a share of
Common Stock on any determined date means: (a) if the principal market for the
Common Stock is The New York Stock Exchange, any other national securities
exchange or The Nasdaq National Market, the closing sales price of the Common
Stock on such day as reported by such exchange or market, or on a consolidated
tape reflecting transactions on such exchange or market, or (b) if the principal
market for the Common Stock is not a national securities exchange or The Nasdaq
National Market and the Common Stock is quoted on the National Association of
Securities Dealers Automated Quotations System, the mean between the closing bid
and the closing asked prices for the Common Stock on such day as quoted on such
System, or (c) if the Common Stock is not quoted on the National Association of
Securities Dealers Automated Quotations System, the mean between the highest bid
and lowest asked prices for the Common Stock on such day as reported by the
National Quotation Bureau, Inc.; PROVIDED, that if none of (a), (b) or (c) above
is applicable, or if no trades have been made or no quotes are available for
such day, the Fair Market Value of the Common Stock shall be determined, in good
faith, by the Board of Directors of the Company.

        3.      ADJUSTMENTS.

                3.1     STOCK SPLITS, STOCK DIVIDENDS AND COMBINATIONS. If the
Company at any time subdivides the outstanding shares of the Common Stock or
issues a stock dividend (in

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Common Stock) on the outstanding shares of the Common Stock, the Exercise Price
in effect immediately prior to such subdivision or the issuance of such stock
dividend shall be proportionately decreased, and the number of Shares subject
hereto shall be proportionately increased, and if the Company at any time
combines (by reverse stock split or otherwise) the outstanding shares of Common
Stock, the Exercise Price in effect immediately prior to such combination shall
be proportionately increased, and the number of Shares subject hereto shall be
proportionately decreased, effective at the close of business on the date of
such subdivision, stock dividend or combination, as the case may be.

                3.2     MERGER OR CONSOLIDATION. In the case of any
consolidation of the Company with, or merger of the Company with or into another
entity (other than a consolidation or merger which does not result in any
reclassification or change of the outstanding capital stock of the Company), the
entity formed by such consolidation or merger shall execute and deliver to the
Warrant Holder a supplemental warrant agreement providing that the Warrant
Holder of the Warrant then outstanding or to be outstanding shall have the right
thereafter (until the expiration of such Warrant) to receive, upon exercise of
such Warrant, the kind and amount of shares of capital stock and other
securities and property receivable upon such consolidation or merger by a holder
of the number of Shares for which such Warrant might have been exercised
immediately prior to such consolidation or merger. Such supplemental warrant
agreement shall provide for adjustments which shall be identical to the
adjustments provided in Section 3.1 hereof and to the provisions of Section 10
hereof. This Section 3.2 shall similarly apply to successive consolidations or
mergers.

                3.3     The Exercise Price shall also be subject to adjustment
as follows:

                        (1)     SPECIAL DEFINITIONS. For purposes of this
Section 3.3, the following definitions shall apply:

                                (A)     "Options" shall mean rights, options or
warrants to subscribe for, purchase or otherwise acquire Common Stock or
Convertible Securities.

                                (B)     "Original Issue Date" shall mean the
date of this Agreement.

                                (C)     "Convertible Securities" shall mean any
evidence of indebtedness, shares of capital stock (other than Common Stock) or
other securities convertible into or exchangeable for Common Stock.

                                (D)     "Additional Shares of Common Stock"
shall mean all shares of Common Stock issued by the Company on or after the
Original Issue Date, other than shares of Common Stock issued at any time:

                                        (i)     upon exercise of the Warrant or
conversion of the Note issued pursuant to the Note and Warrant Purchase
Agreement;

                                        (ii)    pursuant to the exercise of
options, warrants or other Common Stock purchase rights issued (or to be issued)
to employees, officers or directors of, or consultants or advisors to, or any
strategic ally of, the Company pursuant to any stock purchase or stock option
plan or other arrangement approved by the Board of Directors;

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                                        (iii)   pursuant to the exercise of
options, warrants or Convertible Securities outstanding as of the Original Issue
Date; or

                                        (iv)    in connection with the
acquisition of all or part of another entity by stock acquisition, merger,
consolidation or other reorganization, or by the purchase of all or part of the
assets of such other entity (including securities issued to persons formerly
employed by such other entity and subsequently hired by the Company and to any
brokers or finders in connection therewith) where the Company or its
stockholders own more than fifty (50%) percent of the voting power of the
acquired, surviving, combined or successor company.

                        (2)     ISSUANCE OF OPTIONS AND CONVERTIBLE SECURITIES.
Subject to Section 3.3(1)(D) hereof, in the event the Company at any time or
from time to time after the Original Issue Date shall issue any Options or
Convertible Securities, then the number of shares of Common Stock actually
issued upon the exercise of such Options or, in the case of Convertible
Securities, the actual conversion or exchange of such Convertible Securities,
shall be deemed to be Additional Shares of Common Stock.

                        (3)     ADJUSTMENT OF EXERCISE PRICE UPON ISSUANCE OF
ADDITIONAL SHARES OF COMMON Stock. In the event the Company, after the Original
Issue Date, shall issue Additional Shares of Common without consideration or for
a consideration per share less than the then-applicable Exercise Price, then and
in such event, such Exercise Price shall be reduced, concurrently with such
issue, to a price (calculated to the nearest cent) determined by multiplying the
then-applicable Exercise Price by a fraction, (i) the numerator of which shall
be the number of shares of Common Stock issued and outstanding (on a
fully-diluted basis) immediately prior to such issuance plus the quotient
obtained by dividing (x) the aggregate consideration received by the Company for
the total number of Additional Shares of Common Stock so issued by (y) the
Conversion Price, and (ii) the denominator of which shall be the number of
shares of Common Stock issued and outstanding (on a fully-diluted basis)
immediately prior to such issuance plus the number of Additional Shares of
Common Stock so issued. Upon each such adjustment of the then-applicable
Exercise Price pursuant to the provisions of this Section 3.3(3), the number of
Warrant Shares purchasable upon the exercise of each Warrant shall be adjusted
to the nearest full amount by multiplying a number equal to the Exercise Price
in effect immediately prior to such adjustment by the number of Warrant Shares
purchasable upon the exercise of each Warrant immediately prior to such
adjustment and dividing the product so obtained by the adjusted Exercise Price.

                        (4)     DETERMINATION OF CONSIDERATION. For purposes of
this Section 3, the consideration received by the Company for the issue of any
Additional Shares of Common Stock shall be computed as follows:

                                (A)     CASH AND PROPERTY. Such consideration
shall:

                                        (i)     insofar as it consists of cash,
be computed at the gross amount of cash received by the Company, excluding only
expenses, discounts and commissions actually paid by the Company in connection
with such issuance or sale and amounts paid or payable for accrued interest.

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                                        (ii)    insofar as it consists of
property other than cash, be computed at the fair value thereof at the time of
such issue, as reasonably determined in good faith by the Board of Directors,
excluding only the expenses as set forth in clause (i) above; and

                                        (iii)   in the event Additional Shares
of Common Stock are issued together with other shares or securities or other
assets of the Company for consideration that covers both cash and property other
than cash, the proportion of such consideration so received, computed as
provided in clauses (i) and (ii) above, shall be as reasonably determined in
good faith by the Board of Directors.

                                (B)     OPTIONS AND CONVERTIBLE SECURITIES. The
consideration per share received by the Company for Additional Shares of Common
Stock issued pursuant to Section 3.3(2), relating to Options and Convertible
Securities, shall be determined by dividing:

                                        (i)     the total amount, if any,
received by the Company as consideration for the issuance of such Options or
Convertible Securities, plus the aggregate amount of additional consideration
paid or payable to the Company upon the exercise of such Options or the
conversion or exchange of such Convertible Securities, or in the case of Options
for Convertible Securities, the exercise of such Options for Convertible
Securities and the conversion or exchange of such Convertible Securities
(subject to any adjustments in the exercise price thereof), by

                                        (ii)    the number of shares of Common
Stock issued or issuable upon the exercise of such Options or the conversion or
exchange of such Convertible Securities or, in the case of Options for
Convertible Securities, the exercise of such Options for Convertible Securities
and the conversion or exchange of such Convertible Securities.

                3.4     CERTIFICATE AS TO ADJUSTMENTS. Upon the occurrence of
each adjustment or readjustment of the Exercise Price pursuant to this Section
3, the Company, at its expense, shall promptly compute such adjustment or
readjustment of the Exercise Price in accordance with the terms hereof and
furnish to each Holder of a Warrant a certificate setting forth such adjustment
or readjustment and showing in detail the facts upon which such adjustment or
readjustment is based, including a statement of (i) the consideration received
or deemed to be received by the Company for any Additional Shares of Common
Stock issued or deemed to have been issued, (ii) the Exercise Price in effect
immediately prior to such adjustment or readjustment, (iii) the number of
Additional Shares of Common Stock issued or deemed to have been issued and (iv)
the number of shares of Common Stock and the amount, if any, of other securities
or property that at the time would be received upon the exercise of the Warrant.
The Company shall, upon the written request at any time of any Holder of a
Warrant, furnish or cause to be furnished to such Holder a like certificate
setting forth (x) all adjustments and readjustments of the Exercise Price since
the Original Issue Date and (y) the Exercise Price then in effect.

                3.5.    ASSURANCES WITH RESPECT TO EXERCISE RIGHTS. The Company
shall not, by amendment of its Certificate of Incorporation or By-laws or
through any reorganization, transfer of assets, consolidation, merger,
dissolution, issue or sale of securities or any other voluntary action, avoid or
seek to avoid the observance or performance of any of the terms to be observed
or performed hereunder by the Company, but shall at all times, in good faith,
assist in the carrying out of all the provisions of this Agreement and in taking
of all such actions as may be

                                       5
<PAGE>

necessary or appropriate in order to protect the exercise rights of the Warrant
Holder against impairment or dilution.

        4.      TRANSFERS.

                4.1     UNREGISTERED SECURITIES. Warrant Holder hereby
acknowledges and agrees that the Warrant and the Shares have not been registered
under the Securities Act of 1933, as amended (the "Securities Act"), and are
"restricted securities" under the Securities Act inasmuch as they are being
acquired in a transaction not involving a public offering, and the Warrant
Holder agrees not to sell, pledge, distribute, offer for sale, transfer or
otherwise dispose of the Warrant or any Shares issued upon exercise of the
Warrant in the absence of (a) an effective registration statement under the Act
as to the Warrant or such Shares and registration and/or qualification of the
Warrant or such Shares under any applicable Federal or state securities law then
in effect or (b) an opinion of counsel, reasonably satisfactory to the Company,
that such registration and qualification are not required.

                4.2     TRANSFERABILITY. Subject to the provisions of Section
4.1 hereof, the rights under this Agreement are freely transferable, in whole or
in part, by the Warrant Holder, and such transferee shall have the same rights
hereunder as the Warrant Holder.

                4.3     WARRANT REGISTER. The Company will maintain a register
containing the names and addresses of the Warrant Holders of the Warrant. Until
any transfer of Warrant in accordance with this Agreement is reflected in the
warrant register, the Company may treat the Warrant Holder as the absolute owner
hereof for all purposes. Any Warrant Holder may change such Warrant Holder's
address as shown on the warrant register by written notice to the Company
requesting such change.

        5.      NO FRACTIONAL SHARES. Any adjustment in the number of Shares
purchasable hereunder shall be rounded to the nearest whole share.

        6.      INVESTMENT REPRESENTATIONS. The Warrant Holder agrees and
acknowledges that it is acquiring the Warrant and will be acquiring the Shares
for its own account and not with a view to any resale or distribution other than
in accordance with Federal and state securities laws. The Warrant Holder is an
"accredited investor" within the meaning of Rule 501(a) of Regulation D
promulgated under the Securities Act.

        7.      COVENANTS AS TO THE SHARES. The Company covenants and agrees
that the shares of capital stock issuable upon exercise of the Warrant, will,
upon issuance in accordance with the terms hereof, be duly and validly issued
and outstanding, fully paid and nonassessable, with no personal liability
attaching to the ownership thereof, and free from all taxes, liens and charges
with respect to the issuance thereof imposed by or through the Company;
PROVIDED, HOWEVER, that the Company shall not be required to pay any tax that
may be payable in respect of any transfer involved in the issuance and delivery
of any certificates in respect of such shares in a name other than that of the
Warrant Holder and the Company shall not be required to issue or deliver such
certificates unless or until the person(s) requesting the issuance thereof shall
have paid to the Company the amount of such tax or it shall be established to
the satisfaction of the Company that such tax has been paid. The Company further
covenants and agrees that the Company will at all times have authorized and
reserved, free from preemptive rights imposed by or through the

                                       6
<PAGE>

Company, a sufficient number of shares of capital stock to provide for the
exercise of the rights represented under this Agreement.

        8.      LEGEND. Any certificate evidencing the Shares issuable upon
exercise hereof will bear a legend indicating that such securities have not been
registered under the Securities Act or under any state securities laws and may
not be sold or offered for sale in the absence of an effective registration
statement as to the securities under the Securities Act and any applicable state
securities law or an opinion of counsel reasonably satisfactory to the Company
that such registration is not required.

        9.      RIGHTS APPLICABLE TO THE WARRANT SHARES. The parties hereby
acknowledge and agree that the Shares, when issued in accordance with the terms
hereof, shall be entitled to all of rights and privileges provided to the
Registration Rights Agreement (as such term is defined in the Note and Warrant
Purchase Agreement).

        10.     DIVIDENDS AND OTHER DISTRIBUTIONS. In the event that the Company
shall, at any time prior to the exercise of all Warrants, declare a dividend
(other than a dividend consisting solely of shares of Common Stock) or otherwise
distribute to its stockholders any assets, properties, rights, evidence of
indebtedness, securities (other than shares of Common Stock), whether issued by
the Company or by another person, or any other thing of value, the Warrant
Holder shall thereafter be entitled, in addition to the shares of Common Stock
or other securities and property receivable upon the exercise thereof, to
receive, upon the exercise of such Warrant, the same property, assets, rights,
evidences of indebtedness, securities or any other thing of value that the
Warrant Holder would have been entitled to receive at the time of such dividend
or distribution as if the Warrant had been exercised immediately prior to such
dividend or distribution. At the time of any such dividend or distribution, the
Company shall make (and maintain) appropriate reserves to ensure the timely
performance of the provisions of this Section 10.

        11.     MISCELLANEOUS.

                11.1    WAIVERS AND AMENDMENTS. This Agreement or any provisions
hereof may be changed, waived, discharged or terminated only by a statement in
writing signed by the Company and by the Warrant Holder.

                11.2    GOVERNING LAW. This Agreement shall be governed by and
construed and enforced in accordance with the laws of the State of New York.

                11.3    NOTICES. All notices and other communications hereunder
shall be in writing and shall be deemed to have been given when delivered by
hand or by facsimile transmission, when telexed, or upon receipt when mailed by
registered or certified mail (return receipt requested), postage prepaid, to the
parties at the following addresses (or at such other address for a party as
shall be specified by like notice):

                (i)     If to the Company:

                        Vyteris, Inc.
                        13-01 Pollitt Drive
                        Fair Lawn, New Jersey 07410

                                       7
<PAGE>

                        Attention:  Chief Executive Officer
                        Facsimile:  (201) 796-6057

                        With a copy (which copy shall not constitute notice) to:

                         Lowenstein Sandler PC
                         65 Livingston Avenue
                         Roseland, New Jersey 07068
                         Attention: Peter H. Ehrenberg, Esq.
                         Facsimile: (973) 597-2400

                (ii)    If to the Warrant Holder:

                        Spencer Trask Specialty Group, LLC
                        535 Madison Avenue
                        New York, NY  10022
                        Attention:  Bruno Lerer, Esq.
                        Facsimile:  (212) 486-7392

                        With a copy (which copy shall not constitute notice) to:

                        Littman Krooks LLP
                        655 Third Avenue, 20th Floor
                        New York, NY  10016
                        Attention:  Mitchell C. Littman, Esq.
                        Facsimile:  (212) 490-2990

                11.4    HEADINGS. The headings in this Agreement are for
convenience of reference only, and shall not limit or otherwise affect the terms
hereof.

                11.5    CLOSING OF BOOKS. The Company will at no time close its
transfer books against the transfer of any Shares issued or issuable upon the
exercise of the Warrant in a manner that interferes with the timely exercise of
the Warrant.

                11.6    NO RIGHTS OR LIABILITIES AS A STOCKHOLDER. This
Agreement shall not entitle the Warrant Holder hereof to any voting rights or
other rights as a stockholder of the Company with respect to the Shares prior to
the exercise of the Warrant. No provision of this Agreement, in the absence of
affirmative action by the Warrant Holder to purchase the Shares, and no mere
enumeration herein of the rights or privileges of the Warrant Holder, shall give
rise to any liability of such Holder for the Exercise Price or as a stockholder
of the Company, whether such liability is asserted by the Company or by
creditors of the Company.

                                       8
<PAGE>

                11.7    SUCCESSORS. All the covenants and provisions of this
Agreement shall be binding upon and inure to the benefit of the parties hereto
and their respective successors and permitted assigns and transferees.

                11.8    SEVERABILITY. If any provision of this Agreement shall
be held to be invalid and unenforceable, such invalidity or unenforceability
shall not affect any other provision of this Agreement.

                            [SIGNATURE PAGE FOLLOWS]

                                       9
<PAGE>

        IN WITNESS WHEREOF, the undersigned have caused this Agreement to be
executed as of the date first written above.

                                        Vyteris Holdings (Nevada), Inc.

                                        By: /s/ Timothy J. McIntyre
                                            Name: Timothy J. McIntyre
                                            Title: President & CEO

                                        By: /s/ Michael McGuinness
                                            Name: Michael McGuinness
                                            Title: Vice President & CFO

                                        SPENCER TRASK SPECIALTY GROUP, LLC

                                        By: /s/ Donald F. Farley
                                            Name: Donald F. Farley
                                            Title: Chief Executive Officer

                                       10
<PAGE>

                                    EXHIBIT A

                               NOTICE OF EXERCISE

                   (To be signed only on exercise of Warrant)

        Dated:________________________

        To:     Vyteris Holdings (Nevada), Inc.

        The undersigned, pursuant to the provisions set forth in the attached
Warrant Agreement, hereby irrevocably elects to:

        [ ]     purchase _____ shares of Common Stock covered by such Warrant
Agreement and herewith makes a cash payment of $_____________, representing the
full purchase price for such shares at the price per share provided for in such
Warrant Agreement.

        [ ]     purchase _____ shares of Common Stock covered by such Warrant
Agreement and herewith delivers _____ shares of Common Stock having a Fair
Market Value as of the last trading day preceding the date hereof of $______,
representing the full purchase price for such shares at the price per shares
provided for in such Warrant Agreement.

        [ ]     acquire in a cashless exercise _____ shares of Common Stock
pursuant to the terms of Section 2.1 of such Warrant Agreement.

        Please issue a certificate or certificates representing such shares of
Common Stock in the name of the undersigned or in such other name as is
specified below.

Signature:________________________________

Name (print):_____________________________

Title (if applicable):____________________

Company (if applicable):__________________

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