Document:

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                                                                   Exhibit 10.20

                            AMICUS THERAPEUTICS, INC.

                        RESTRICTED SHARE AWARD AGREEMENT

     THIS RESTRICTED SHARE AWARD AGREEMENT (the "Award Agreement") is dated this
8th day of March, 2007, by and between Amicus Therapeutics, Inc., a Delaware
corporation (the "Company"), and James E. Dentzer (the "Associate").

     WHEREAS, on July 26, 2006, the Company and the Associate entered into that
certain offer letter (the "Offer Letter") in connection with Associate's
employment with the Company;

     WHEREAS, among the terms set forth in the Offer Letter was an award (the
"Award") of 300,000 shares of common stock, $.01 par value (the "Common Stock")
under the Amicus Therapeutics, Inc. 2002 Equity Incentive Plan (the "Plan"),
effective upon the commencement of Associate's employment with the Company; and

     NOW, THEREFORE, in consideration of the foregoing and the mutual
obligations set forth herein, the Company and the Associate agree as follows:

     1. Award. The Award to the Associate of restricted shares ("Restricted
Shares") of Common Stock is subject to the terms and conditions set forth in
this Restricted Share Award Agreement ("Award Agreement" or "Award"), and in the
Plan. By executing this Award Agreement, the Associate agrees to be bound by all
the Plan's terms and conditions as if they had been set forth specifically
herein. Capitalized terms used but not otherwise defined herein are defined in
the Plan.

     2. Specific Terms. The Associate's Award of Restricted Shares have the
following terms:

     Number of Restricted Shares
     Awarded:                        300,000

     Award Date:                     October 2, 2006

     Vesting:                        The Restricted Shares shall vest as
                                     follows:

                                     75,000 shares shall vest on the first
                                     anniversary of the Award Date (the
                                     "Anniversary Date").

                                     6,250 shares shall vest monthly, beginning
                                     on the first day of each of the thirty-six
                                     (36) calendar months following the
                                     Anniversary Date.
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     3.   Issuance of Restricted Shares. The Company shall reflect the issuance
in the Associate's name of all the Restricted Shares subject to this Award.
Such Restricted Shares shall be held in the custody of the Company or its
designee for the Associate's account. The Restricted Shares shall be subject to
the restrictions set forth herein. Until applicable vesting restrictions lapse,
any certificates that the Associate receives for Restricted Shares will include
a legend stating that they are subject to the restrictions set forth in the
Plan and this Award Agreement.

     4.   Acceleration of Vesting of Restricted Shares.

          a.   Resignation for Good Reason after Change in Control Event. If,
prior to the expiration of the term of Associate's employment with the Company
(the "Employment Term") pursuant to the Offer Letter, but after the occurrence
of a Change in Control Event (as defined below), the Associate resigns for Good
Reason (as defined below) within six (6) months of such Change in Control
Event, the entire Award of Restricted Shares shall vest and immediately become
fully exercisable.

          b.   Termination by the Company without Cause. If, prior to the
expiration of the Employment Term, the Company terminates Associate's
employment without Cause (as defined below), then the Award shall vest with
respect to an additional six (6) months of vesting, measured from the date of
termination of employment.

          c.   Release. In order for the vesting of the Award to accelerate as
provided in this Section 4, Associate must execute and deliver to the Company a
release, the form and substance of which are acceptable to the Company.

          d.   Definitions. For purposes of this Section 4, the following
definitions shall have the meanings set forth below;

               (i)  "Cause" means for any of the following reasons: (i) willful
                    or deliberate misconduct by Associate that materially
                    damages the Company; (ii) misappropriation of Company
                    assets; (iii) Associate's conviction of, or a plea of guilty
                    or "no contest" to, a felony; or (iv) any willful
                    disobedience of the lawful and unambiguous instructions of
                    the Chief Executive Officer of the Company; provided that
                    the Chief Executive Officer has given Associate written
                    notice of such disobedience or neglect and Associate has
                    failed to cure such disobedience or neglect within a
                    period reasonable under the circumstances.

               (ii) "Change in Control Event" means any of the following: (i)
                    any person or entity (except for a current stockholder)
                    becomes the beneficial owner of greater than 50% of the then
                    outstanding voting power of the Company; (ii) a merger or
                    consolidation with another entity where the voting
                    securities of the Company outstanding immediately before the
                    transaction constitute less than a majority of the voting
                    power of the voting securities of the
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                    Company or the surviving entity outstanding immediately
                    after the transaction, or (iii) the sale or disposition of
                    all or substantially all of the Company's assets.

          (iii)     "Good Reason" means (i) a change in Associate's position
                    with the Company or its successor that materially reduces
                    Associate's title, duties or level of responsibility; or
                    (ii) the relocation of the Company or its successor greater
                    than 50 miles away from the then current location of the
                    Company's principal offices.

     5.   Forfeiture of Restricted Shares. In the event that the Associate is
no longer an employee of the Company, any unvested Restricted Shares (including
dividends paid thereon), shall be automatically forfeited (the "Forfeited
Shares") and returned to the Company for cancellation upon the effective day of
the end of the Associate's employment. "Employment" for the purposes of this
Agreement shall be defined in accordance with the provisions of Section Treas.
Reg. 1.421-7(h) or any successor regulations.

     6.   Stockholder Rights; Unvested Restricted Shares.

               a.   The Company will hold the Restricted Shares in escrow until
applicable vesting occurs, if ever. The Associate must deliver to the Company,
coincident with the execution and delivery of this Award Agreement, a stock
power, endorsed in blank, for each certificate issued and representing the
Restricted Shares to enable the Company to return and/or reissue such
certificates as provided in this Award Agreement.

               b.   If an event causes the Associate to forfeit any Restricted
Shares, the stock powers will be used to return the certificates for the
Forfeited Shares for cancellation. To the extent that a portion of a
certificate represents Forfeited Shares and shares which are not Forfeited
Shares, then the Company will reissue a certificate to the Associate for such
number of shares of Common Stock which do not represent Forfeited Shares and the
stock powers shall be effective such purpose.

               c.   Subject to this Award Agreement, as the owner of record of
the Restricted Shares, the Associate's name will be reflected as such on the
Company's books and records, and the Associate will be entitled to all
rights of a Company stockholder, including voting and dividend rights with
respect to the Restricted Shares; provided however, that dividends paid with
respect to those Restricted Shares, whether in cash or stock, that have not
vested at the time of the dividend payment shall themselves be subject to the
same restrictions, vesting and forfeiture conditions that apply to the
corresponding restricted Shares.

     7.   Transfer Restrictions. No Portion of the Restricted Shares may
be sold, transferred, assigned, pledged or otherwise encumbered or disposed of
by the Associate until such Restricted Shares have vested in accordance with
Section 1 hereof and then only in accordance with applicable securities laws and
any Company policy then in effect, should such policy then apply to the
Associate. The Company shall not be required (i) to transfer on its books any
Restricted Shares that have been sold or otherwise transferred in violation of
any provision
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of this Award Agreement, or (ii) to treat as owner of such shares or to accord
the right to vote or pay dividends to any purchaser or other transferee to whom
the Associate has attempted to transfer such shares.

     8.    Right of First Refusal. If the Associate wishes to sell or otherwise
transfer any of the vested Restricted Shares, then at least 30 days prior to any
such transfer, the Associate shall give notice to the Company (the "Notice").
The Notice shall set forth (i) the number of Restricted Shares proposed to be
sold or transferred; (ii) the date or proposed date of the sale or transfer;
(iii) the identity of the proposed transferee; and (iv) the principal terms of
the transfer, including the cash or other property or consideration to be
received upon such transfer. The Company shall have the right, but not the
obligation, to purchase all, but not less than all, of the Restricted Shares on
the same terms specified in the Notice. Within 30 days after receipt of the
Notice, the Company shall give written notice (the "Company Notice") to the
Associate stating whether or not it elects to exercise its right to purchase the
Restricted Shares and a date and time for consummation of such purchase, not
more than 10 days after the receipt by the Associate of the Company Notice.
Failure by the Company to deliver a Company Notice within such time period shall
be deemed an election by the Company not to exercise its right to purchase the
Restricted Shares. If the Company does not exercise its right to purchase the
Restricted Shares, then the Associate shall be free to transfer the Restricted
Shares on the terms provided in the Notice. Any Restricted Shares not purchased
within a period of 90 days of the Notice by the proposed transferee in the
Notice may not be sold or otherwise disposed of until they are again offered to
the Company under the procedures specified in this Section 6. The Company's
right of first refusal described in this Section 6 shall terminate upon the
closing of an initial public offering of the Company's Common Stock.

     9.   Restrictions on Public Sale by Associate. In connection with any
public offering, the Associate, if requested by the Company and the underwriters
managing such public offering, shall agree not to sell or otherwise transfer or
dispose of any Restricted Shares or other securities of the Company held by the
Associate (other than those Restricted Shares or other securities, if any,
included in the public offering) for a specified period of time determined by
the Company and the underwriters following the effective date of a registration
statement with the Securities and Exchange Commission covering such public
offering (the "Registration Statement"); provided, however, that. (i) such
agreement shall not exceed 180 days from the effective date of such
registration; (ii) all other Restricted Holders enter into similar agreements;
provided, however, that all restrictions set forth in this Section 7 shall
terminate and be of no further force or effect if any other Restricted Holder is
released from, or otherwise no longer bound by, such restrictions; and (iii)
such agreement shall only apply to the first such Registration Statement
covering Common Stock of the Company to be sold on its behalf to the public in
an initial public offering of securities by the Company. For purposes of this
Section 7, "Restricted Holders" shall mean: (x) parties to that certain Third
Amended and Restated Investor Rights Agreement, dated September 13, 2006, by and
among the Company and the stockholders named therein, and (y) any officer or
director of the Company.

     10.  Taxes and Withholding. No later than the date as of which an amount
first becomes includible in the gross income of the Associate for federal income
tax purposes with respect to any Restricted Shares, the Associate shall pay to
the Company, or make arrangements satisfactory to the Company regarding the
payment of, all federal, state, local and foreign taxes
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that are required by applicable laws and regulations to be withheld with respect
to such amount. Notwithstanding anything to the contrary contained herein, the
Associate may discharge this withholding obligation by directing the Company to
withhold Restricted Shares with a value on a vesting date equal to the minimum
withholding obligation in connection with such vesting. The Company shall, to
the extent permitted by law, have the right to deduct any such taxes from the
delivery of the Restricted Shares that gives rise to the withholding
requirement.

     11.  REPRESENTATIONS.  The Associate represents, warrants and covenants to
the Company that:

          a.  The Restricted Shares are being acquired for the Associate's
     account for investment only and not with a view to, or for sale in
     connection with, any distribution of the Restricted Shares in violation of
     the Securities Act of 1933, as amended, or any rule or regulation
     thereunder.

          b.  The Associate has had such opportunity as he or she has deemed
     adequate to obtain from representatives of the Company such information as
     is necessary to permit the Associate to evaluate the merits and risks of an
     investment in the Company.

          c.  The Associate is able to bear the economic risk of holding such
     Restricted Shares for an indefinite period.

          d.  The Associate understands that (i) the Restricted Shares will not
     be registered under the Securities Act and are "restricted securities"
     within the meaning of Rule 144 under the Securities Act; (ii) the
     Restricted Shares cannot be sold, transferred or otherwise disposed of
     unless they are subsequently registered under the Securities Act or an
     exemption from registration is then available; (iii) in any event, the
     exemption from registration under Rule 144 will not be available for at
     least one year and even then will not be available unless a public market
     then exists for the Company's Common Stock, adequate information concerning
     the Company is then available to the public, and other terms and conditions
     of Rule 144 are complied with; and (iv) the Company has no obligation or
     current intention to register any Restricted Shares acquired pursuant to
     this Award under the Securities Act.

          e.   The Associate hereby represents that the Associate has obtained
     appropriate legal or tax advice with respect to the tax consequences to the
     Associate of the Award.

          f.   All stock certificates representing Restricted Shares issued to
     the Associate shall have affixed thereto legends substantially in the
     following form, in addition to any other legends required by applicable
     state law:

          THE SHARES EVIDENCED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED
          UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR APPLICABLE STATE
          SECURITIES LAWS AND MAY NOT BE SOLD, ASSIGNED, TRANSFERRED, PLEDGED,
          HYPOTHECATED OR OTHERWISE DISPOSED OF EXCEPT PURSUANT TO (1)
          REGISTRATION IN COMPLIANCE WITH SAID ACT

                                       5
<PAGE>
          AND SUCH STATE LAWS, OR (2) AN OPINION OF COUNSEL FOR THE COMPANY TO
          THE EFFECT THAT SUCH DISPOSITION WOULD NOT CONSTITUTE A VIOLATION OF
          ANY RELEVANT FEDERAL OR STATE SECURITIES LAWS.

               THE SHARES EVIDENCED BY THIS CERTIFICATE ARE SUBJECT TO A RIGHT
          OF FIRST REFUSAL AND RESTRICTIONS ON RESALE CONTAINED IN A RESTRICTED
          SHARE AWARD AGREEMENT BETWEEN THE COMPANY AND THE HOLDER HEREOF. A
          COPY OF SUCH AGREEMENT IS ON FILE AT THE PRINCIPAL OFFICES OF THE
          COMPANY.

          12.  Consent of Spouse/Domestic Partner. If the Associate has a spouse
     or domestic partner as of the date of this Award Agreement, the Associate's
     spouse or domestic partner shall execute a Consent of Spouse/Domestic
     Partner in the form of Exhibit A hereto, effective as of the date hereof.
     Such consent shall not be deemed to confer or convey to the spouse or
     domestic partner any rights in the Restricted Shares that do not otherwise
     exist by operation of law or the agreement of the parties. If the Associate
     subsequent to the date hereof, marries, remarries or applies to the Company
     for domestic partner benefits, the Associate shall, not later than 60 days
     thereafter, obtain his or her new spouse/domestic partner's acknowledgement
     of and consent to the existence and binding effect of all restrictions
     contained in this Award Agreement by having such spouse/domestic partner
     execute and deliver a Consent of Spouse/Domestic Partner in the form of
     Exhibit A.

          13.  Miscellaneous.

               a.  This Award Agreement and any instruments delivered pursuant
          to this Award Agreement shall be construed, interpreted and governed
          in accordance with the laws of the State of New Jersey, without regard
          to the conflicts of law rules thereof.

               b.  Any claim or controversy arising out of, or relating to, this
          Award Agreement, other than with respect to any confidentiality
          agreement between Associate and the Company (or any officer, director,
          employee or agent of the Company), or the beach thereof, shall be
          settled by arbitration administrated by the American Arbitration
          Association under its National Rules for the Resolution of Employment
          Disputes. Such arbitration shall be held in New Jersey (or in such
          other location as the Company may at the time be headquartered). The
          arbitration shall be conducted before a three-member panel. Within
          fifteen (15) days after the commencement of arbitration, each party
          shall elect one person to act as arbitrator and the two selected shall
          select a third arbitrator within ten (10) days of their appointment.
          If the arbitrators selected by the parties are unable or fail to agree
          upon the third arbitrator, the third arbitrator shall be selected by
          the American Arbitration Association and shall be a member of the bar
          of the State of New Jersey actively engaged in the practice of
          employment law for at least ten years. The arbitration panel shall
          apply the substantive laws of the State of New Jersey in connection
          with the arbitration and the New Jersey Rules of Evidence shall apply
          to all aspects of the arbitration. The award shall be made within
          thirty days of the closing of the hearing. Judgment upon the award
          rendered by the arbitrator(s) may be entered by any Court having
          jurisdiction thereof.

<PAGE>
     c.   This Award Agreement shall extend to, be binding upon and inure to the
benefit of the Associate, his legal representatives, his heirs, successors and
assigns (subject, however, to the limitations set forth herein with respect to
the assignment of the Award, the Restricted Shares or rights herein) and upon
the Company, its successors and assigns regardless of any change in the
business structure of the Company, be it through spinoff, merger, sale of
stock, sale of assets or any other transaction and shall be construed in a
manner that is consistent with the provisions of the Plan.

     d.   This Award Agreement contains the entire agreement of the parties
with respect to the  subject matter hereof. No waiver, modification or change of
any provision of this Award Agreement shall be valid unless in writing and
signed by both parties.

     e.   The waiver of any breach of any duty, term or condition of this Award
Agreement shall not be deemed to constitute a waiver of any preceding or
succeeding breach of the same or any other duty, term or condition of this
Award Agreement.

     f.   All notices pursuant to this Award Agreement will be in writing and
will be sent by personal delivery, telecopier, electronic mail or by prepaid
registered or certified mail, return receipt requested, addressed to the parties
hereto at the addresses set forth beneath their names on the signature page
hereto or to such other addresses as may hereafter be specified by like notice
in writing by either of the parties, and will be deemed given (i) upon receipt
if by personal delivery, (ii) on the day on which delivered if delivered by
telecopier (with confirmation of receipt (such receipt to be established by
acceptable protocol)), (iii) upon mailing if sent by registered or certified
mail or (iv) when transmitted if delivered by electronic mail (with satisfactory
evidence of transmittal (such evidence of transmittal to be established by
acceptable protocol)). Copies of all notices shall be sent to: Amicus
Therapeutics, Inc., 6 Cedar Brook Drive, Cranbury, NJ 08512 Attention: VP, Human
Resources and Leadership Development, Telecopier No.609-662-2004.

     g.   The headings of the sections of this Award Agreement are inserted for
convenience of reference only and will not be deemed to constitute a part
hereof or to affect the meaning hereof.

     h.   This Award Agreement may be executed in counterparts, each of which
shall be deemed an original but all of which shall together constitute one and
the same agreement.

                            [SIGNATURE PAGE FOLLOWS]

                                       7
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     By the signature of the Associate below, along with the signature of the
Company's authorized representative, the Associate and the Company agree that
the Restricted Shares are awarded under and governed by the terms and conditions
of this Award Agreement and the Plan.

                                             AMICUS THERAPEUTICS, INC.

Date:                                        By: /s/ John F. Crowley
      ----------------------------------         -----------------------------
                                                 Name:  John F. Crowley
                                                 Title: President & CEO

                                             Address: 6 Cedar Brook Drive
                                                      Cranbury, NJ 08512

                             ASSOCIATES ACCEPTANCE

     The undersigned hereby accepts the foregoing Award Agreement and agrees to
the terms and conditions thereof. The undersigned hereby acknowledges receipt of
a copy of the Company's 2002 Equity Incentive Plan.

                                             RECIPIENT

Date: 3/27/07                                By: /s/ James E. Dentzer
      ----------------------------------         -----------------------------
                                                 Name:    -- James E. Dentzer
                                                 Address: --

                                                 SSN#:    --

                                       8<PAGE>
                                                                   Exhibit 10.21

                           AMICUS THERAPEUTICS, INC.

                        RESTRICTED SHARE AWARD AGREEMENT

     THIS RESTRICTED SHARE AWARD AGREEMENT (the "Award Agreement") is dated
this 8th day of March, 2007, by and between Amicus Therapeutics, Inc., a
Delaware corporation (the "Company"), and Glenn P. Sblendorio (the "Recipient").

     WHEREAS, on June 27, 2006, the Recipient was elected to the Board of
Directors of Company, and the terms of such service were set forth in an offer
letter (the "Offer Letter") of the same date;

     WHEREAS, among the terms set forth in the Offer Letter was an award (the
"Award") of 100,000 shares of common stock, $.01 par value (the "Common Stock")
under the Amicus Therapeutics, Inc. 2002 Equity Incentive Plan (the "Plan"); and

     WHEREAS, on September 13, 2006, the Company's Board of Directors ratified
such Award;

     NOW, THEREFORE, in consideration of the foregoing and the mutual
obligations set forth herein, the Company and the Recipient agree as follows:

     1. Award. The Award to the Recipient of restricted shares ("Restricted
Shares") of Common Stock is subject to the terms and conditions set forth in
this Restricted Share Award Agreement ("Award Agreement"), and the Plan. By
executing this Award Agreement, the Recipient agrees to be bound by all the
Plan's terms and conditions as if they had been set forth specifically herein.
Capitalized terms used but not otherwise defined herein are defined in the Plan.

     2. Specific Terms. The Recipient's Restricted Shares have the following
terms:

<TABLE>

     <S>                                      <C>
     Number of Restricted Shares Awarded:     100,000

     Award Date:                              June 27, 2006

     Vesting:                                 The Restricted Shares shall vest
                                              as follows:

                                              2,778 shares shall vest on the
                                              first day of each of the
                                              thirty-five (35) calendar months
                                              following the Award Date

                                              2,770 shares shall vest and
                                              become exercisable on June 1, 2009

</TABLE>
<PAGE>
     Forfeiture:         In the event that the Recipient is no longer in
                         service to the Company as a member of the Board of
                         Directors, any unvested Restricted Shares (including
                         dividends paid thereon), shall be automatically
                         forfeited (the "Forfeited Shares") and returned to the
                         Company for cancellation upon the effective day of
                         the end of the Recipient's service.

     3.   Issuance of Restricted Shares. The Company shall reflect the issuance
in the Recipient's name of all the Restricted Shares subject to the Award. Such
Restricted Shares shall be held in the custody of the Company or its designee
for the Recipient's account. The Restricted Shares shall be subject to the
restrictions set forth herein. Until applicable vesting restrictions lapse, any
certificates that the Recipient receives for Restricted Shares will include a
legend stating that they are subject to the restrictions set forth in the Plan
and this Award Agreement.

     4.   Stockholder Rights; Unvested Restricted Shares.

          a.   The Company will hold the Restricted Shares in escrow until
     applicable vesting occurs, if ever. The Recipient must deliver to the
     Company, coincident with the execution and delivery of this Award
     Agreement, a stock power, endorsed in blank, for each certificate issued
     and representing the Restricted Shares to enable the Company to return
     and/or reissue such certificates as provided in this Award Agreement.

          b.   If an event causes the Recipient to forfeit any Restricted
     Shares, the stock powers will be used to return the certificates for the
     Forfeited Shares for cancellation. To the extent that a portion of a
     certificate represents Forfeited Shares and shares which are not Forfeited
     Shares, then the Company will reissue a certificate to the Recipient for
     such number of shares of Common Stock which do not represent Forfeited
     Shares and the stock powers shall be effective for such purpose.

          c.   Subject to this Award Agreement, as the owner of record of the
     Restricted Shares, the Recipient's name will be reflected as such on the
     Company's books and records, and the Recipient will be entitled to all
     rights of a Company stockholder, including voting and dividend rights with
     respect to the Restricted Shares; provided however, that dividends paid
     with respect to those Restricted Shares, whether in cash or stock, that
     have not vested at the time of the dividend payment shall themselves be
     subject to the same restrictions, vesting and forfeiture conditions that
     apply to the corresponding Restricted Shares.

     5.   Transfer Restrictions. No portion of the Restricted Shares may be
sold, transferred, assigned pledged or otherwise encumbered or disposed of by
the Recipient until such Restricted Shares have vested in accordance with
Section 1 hereof and then only in accordance with applicable securities laws
and any Company policy then in effect, should such policy then apply to the
Recipient. The Company shall not be required (i) to transfer on its books

                                       2

<PAGE>
any Restricted Shares that have been sold or otherwise transferred in violation
of any provision of this Award Agreement, or (ii) to treat as owner of such
shares or to accord the right to vote or pay dividends to any purchaser or
other transferee to whom the Recipient has attempted to transfer such shares.

     6. Right of First Refusal. If the Recipient wishes to sell or otherwise
transfer any of the vested Restricted Shares, then at least 30 days prior to
any such transfer, the Recipient shall give notice to the Company (the
"Notice"). The Notice shall set forth (i) the number of Restricted Shares
proposed to be sold or transferred; (ii) the date or proposed date of the sale
or transfer; (iii) the identity of the proposed transferee; and (iv) the
principal terms of the transfer, including the cash or other property or
consideration to be received upon such transfer. The Company shall have the
right, but not the obligation, to purchase all, but not less than all, of the
Restricted Shares on the same terms specified in the Notice. Within 30 days
after receipt of the Notice, the Company shall give written notice (the
"Company Notice") to the Recipient stating whether or not it elects to exercise
its right to purchase the Restricted Shares and a date and time for consummation
of such purchase, not more than 10 days after the receipt by the Recipient of
the Company Notice. Failure by the Company to deliver a Company Notice within
such time period shall be deemed an election by the Company not to exercise its
right to purchase the Restricted Shares. If the Company does not exercise its
right to purchase the Restricted Shares, then the Recipient shall be free to
transfer the Restricted Shares on the terms provided in the Notice. Any
Restricted Shares not purchased within a period of 90 days of the Notice by the
proposed transferee in the Notice may not be sold or otherwise disposed of
until they are again offered to the Company under the procedures specified in
this Section 6. The Company's right of first refusal described in this Section
6 shall terminate upon the closing of an initial public offering of the
Company's Common Stock.

     7. Restrictions on Public Sale by Recipient. In connection with any public
offering, the Recipient, if requested by the Company and the underwriters
managing such public offering, shall agree not to sell or otherwise transfer or
dispose of any Restricted Shares or other securities of the Company held by the
Recipient (other than those Restricted Shares or other securities, if any,
included in the public offering) for a specified period of time determined by
the Company and the underwriters following the effective date of a registration
statement with the Securities and Exchange Commission covering such public
offering (the "Registration Statement"); provided, however, that: (i) such
agreement shall not exceed 180 days from the effective date of such
registration; (ii) all other Restricted Holders enter into similar agreements;
provided, however, that all restrictions set forth in this Section 7 shall
terminate and be of no further force or effect if any other Restricted Holder
is released from, or otherwise no longer bound by, such restrictions; and (iii)
such agreement shall only apply to the first such Registration Statement
covering Common Stock of the Company to be sold on its behalf to the public in
an initial public offering of securities by the Company. For purposes of this
Section 7, "Restricted Holders" shall mean: (x) parties to that certain Third
Amended and Restated Investor Rights Agreement, dated September 13, 2006, by
and among the Company and the stockholders named therein, and (y) any officer
or director of the Company.

     8. Effect of a Reorganization Event. Upon any Reorganization Event (as
defined in the Plan), all shares of Restricted Stock which were unvested at the
time of such Reorganization Event, shall immediately become vested.

                                       3
<PAGE>
     9. Taxes and Withholding. No later than the date as of which an amount
first becomes includible in the gross income of the Recipient for federal
income tax purposes with respect to any Restricted Shares, the Recipient shall
pay to the Company, or make arrangements satisfactory to the Company regarding
the payment of, all federal, state, local and foreign taxes that are required
by applicable laws and regulations to be withheld with respect to such amount.
Notwithstanding anything to the contrary contained herein, the Recipient may
discharge this withholding obligation by directing the Company to withhold
Restricted Shares with a value on a vesting date equal to the minimum
withholding obligation in connection with such vesting. The Company shall, to
the extent permitted by law, have the right to deduct any such taxes from the
delivery of the Restricted Shares that gives rise to the withholding
requirement.

     10. Representations. The Recipient represents, warrants and covenants to
the Company that:

          a. The Restricted Shares are being acquired for the Recipient's
     account for investment only and not with a view to, or for sale in
     connection with, any distribution of the Restricted Shares in violation of
     the Securities Act of 1933, as amended, or any rule or regulation
     thereunder.

          b. The Recipient has had such opportunity as he or she has deemed
     adequate to obtain from representatives of the Company such information as
     is necessary to permit the Recipient to evaluate the merits and risks of an
     investment in the Company.

          c. The Recipient is able to bear the economic risk of holding such
     Restricted Shares for an indefinite period.

          d. The Recipient understands that (i) the Restricted Shares will not
     be registered under the Securities Act and are "restricted securities"
     within the meaning of Rule 144 under the Securities Act; (ii) the
     Restricted Shares cannot be sold, transferred or otherwise disposed of
     unless they are subsequently registered under the Securities Act or an
     exemption from registration is then available; (iii) in any event, the
     exemption from registration under Rule 144 will not be available for at
     least one year and even then will not be available unless a public market
     then exists for the Company's Common Stock, adequate information concerning
     the Company is then available to the public, and other terms and conditions
     of Rule 144 are complied with; and (iv) the Company has no obligation or
     current intention to register any Restricted Shares acquired pursuant to
     this Award under the Securities Act.

          e. The Recipient hereby represents that the Recipient has obtained
     appropriate legal or tax advice with respect to the tax consequences to the
     Recipient of the Award.

          f. All stock certificates representing Restricted Shares issued to
     the Recipient shall have affixed thereto legends substantially in the
     following form, in addition to any other legends required by applicable
     state law:
<PAGE>
     THE SHARES EVIDENCED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE
     SECURITIES ACT OF 1933, AS AMENDED, OR APPLICABLE STATE SECURITIES LAWS AND
     MAY NOT BE SOLD, ASSIGNED, TRANSFERRED, PLEDGED, HYPOTHECATED OR OTHERWISE
     DISPOSED OF EXCEPT PURSUANT TO (1) REGISTRATION IN COMPLIANCE WITH SAID ACT
     AND SUCH STATE LAWS, OR (2) AN OPINION OF COUNSEL FOR THE COMPANY TO THE
     EFFECT THAT SUCH DISPOSITION WOULD NOT CONSTITUTE A VIOLATION OF ANY
     RELEVANT FEDERAL OR STATE SECURITIES LAWS.

     THE SHARES EVIDENCED BY THIS CERTIFICATE ARE SUBJECT TO A RIGHT OF FIRST
     REFUSAL AND RESTRICTIONS ON RESALE CONTAINED IN A RESTRICTED SHARE AWARD
     AGREEMENT BETWEEN THE COMPANY AND THE HOLDER HEREOF. A COPY OF SUCH
     AGREEMENT IS ON FILE AT THE PRINCIPAL OFFICES OF THE COMPANY.

     11. Consent of Spouse/Domestic Partner. If the Recipient has a spouse or
domestic partner as of the date of this Award Agreement, the Recipient's spouse
or domestic partner shall execute a Consent of Spouse/Domestic Partner in the
form of Exhibit A hereto, effective as of the date hereof. Such consent shall
not be redeemed to confer or convey to the spouse or domestic partner any
rights in the Restricted Shares that do not otherwise exist by operation of law
or the agreement of the parties. If the Recipient subsequent to the date
hereof, marries, remarries or applies to the Company for domestic partnership
benefits, the Recipient shall, not later than 60 days thereafter, obtain his or
her new spouse/domestic partner's acknowledgement of and consent to the
existence and binding effect of all restrictions contained in this Award
Agreement by having such spouse/domestic partner execute and deliver a Consent
of Spouse/Domestic Partner in the form of Exhibit A.

     12. Miscellaneous.

          a. This Award Agreement and any instruments delivered pursuant to this
     Award Agreement shall be construed, interpreted and governed in accordance
     with the laws of the State of New Jersey, without regard to the conflicts
     of law rules thereof.

          b. Any claim or controversy arising out of, or relating to, this Award
     Agreement, other than with respect to any confidentiality agreement between
     Recipient and the Company (or any officer, director, employee or agent of
     the Company), or the breach thereof, shall be settled by arbitration
     administered by the American Arbitration Association under its National
     Rules for the Resolution of Employee Disputes. Such arbitration shall be
     held in New Jersey (or in such other location as the Company may at time be
     headquartered). The arbitration shall be conducted before a three-member
     panel. Within fifteen (15) days after the commencement of arbitration, each
     party shall select one person to act as arbitrator and the two selected
     shall select a third arbitrator within ten (10) days of their appointment.
     If the arbitrators selected by the parties are unable or fail to agree upon
     the third arbitrator, the third arbitrator shall be selected by the
     American Arbitration Association and shall be a member of the bar of the
     State of New Jersey actively engaged in the practice of employment law for
     at least ten years. The

                                       5
<PAGE>
arbitration panel shall apply the substantive laws of the State of New Jersey
in connection with the arbitration and the New Jersey Rules of Evidence shall
apply to all aspects of the arbitration. The award shall be made within thirty
days of the closing of the hearing. Judgment upon the award rendered by the
arbitrator(s) may be entered by any Court having jurisdiction thereof.

     c. This Award Agreement shall extend to, be binding upon and inure to the
benefit of the Recipient, his legal representatives, his heirs, successors and
assigns (subject, however, to the limitations set forth herein with respect to
the assignment of the Award, the Restricted Shares or rights herein) and upon
the Company, its successors and assigns regardless of any change in the business
structure of the Company, be it through spinoff, merger, sale of stock, sale of
assets or any other transaction and shall be construed in a manner that is
consistent with the provisions of the Plan.

     d. This Award Agreement contains the entire agreement of the parties with
respect to the subject matter hereof. No waiver, modification or change of any
provision of this Award Agreement shall be valid unless in writing and signed
by both parties.

     e. The waiver of any breach of any duty, term or condition of this Award
Agreement shall not be deemed to constitute a waiver of any preceding or
succeeding breach of the same or any other duty, term or condition of this
Award Agreement.

     f. All notices pursuant to this Award Agreement will be in writing and
will be sent by personal delivery, telecopier, electronic mail or by prepaid
registered or certified mail, return receipt requested, addressed to the
parties hereto at the addresses set forth beneath their names on the signature
page hereto or to such other addresses as may hereafter be specified by like
notice in writing by either of the parties, and will be deemed given (i) upon
receipt if by personal delivery, (ii) on the day on which delivered if
delivered by telecopier (with confirmation of receipt (such receipt to be
established by acceptable protocol)), (iii) upon mailing if sent by registered
or certified mail or (iv) when transmitted if delivered by electronic mail
(with satisfactory evidence of transmittal (such evidence of transmittal to be
established by acceptable protocol)). Copies of all notices shall be sent to:
Amicus Therapeutics, Inc., 6 Cedar Brook Drive, Cranbury, NJ 08512 Attention:
VP, Human Resources and Leadership Development, Telecopier No. 609-662-2004.

     g. The headings of the sections of this Award Agreement are inserted for
convenience of reference only and will not be deemed to constitute a part
hereof or to affect the meaning hereof.

     h. This Award Agreement may be executed in counterparts, each of which
shall be deemed an original but all of which shall together constitute one and
the same agreement.

                             [SIGNATURE PAGE FOLLOWS]

                                         6
<PAGE>
      By the signature of the Recipient below, along with the signature of the
Company's authorized representative, the Recipient and the Company agree that
the Restricted Shares are awarded under and governed by the terms and conditions
of this Award Agreement and the Plan.

                                        AMICUS THERAPEUTICS, INC.

Date: March 8, 2007                     By: /s/ John F. Crowley
                                            -----------------------------------
                                            Name:   John F. Crowley
                                            Title:  President & CEO

                                        Address:  6 Cedar Brook Drive
                                                  Cranbury, NJ 08512

                             RECIPIENT'S ACCEPTANCE

      The undersigned hereby accepts the foregoing Award Agreement and agrees to
the terms and conditions thereof. The undersigned hereby acknowledges receipt of
a copy of the Company's 2002 Equity Incentive Plan.

                                        RECIPIENT

Date: March 8, 2007                     By: /s/ Glenn P Sblendorio
                                            -----------------------------------
                                            Name:    Glenn P Sblendorio
                                            Address: 51 Bramshill Drive
                                                     Mahwah, NJ 07430

                                            SSN#:    ###-##-####

                                       7
<PAGE>
                                                                       EXHIBIT A

                      CONSENT OF SPOUSE/DOMESTIC PARTNER

     I, Rosemary Sblendorio, spouse or domestic partner of Glenn Sblendorio,
acknowledge that I have read the RESTRICTED SHARE AWARD AGREEMENT dated as of
_______(the "Award Agreement") to which this Consent is attached as Exhibit A
and that I know its contents. Capitalized terms used and not defined herein
shall have the meanings assigned to such terms in the Award Agreement. I am
aware that by its provisions the Restricted Shares granted to my spouse/domestic
partner pursuant to the Award Agreement are subject to forfeiture and that,
accordingly, I may be required to forfeit to Amicus Therapeutics, Inc. (the
"Company") any or all of the Restricted Shares of which I may become possessed
as a result of a gift from my spouse/domestic partner or a court decree and/or
any property settlement in any domestic litigation.

     I hereby agree that my interest, if any, in the Restricted Shares subject
to the Award Agreement shall be irrevocably bound by the Award Agreement and
further understand and agree that any community property interest I may have in
the Restricted Shares shall be similarly bound by the Award Agreement.

     I agree to the vesting and forfeiture provisions described in the Award
Agreement and I hereby consent to the forfeiture of the Restricted Shares to the
Company by my spouse/domestic partner or my spouse/domestic partner's legal
representative in accordance with the provisions of the Award Agreement.
Further, as part of the consideration for the Award Agreement, I agree that at
my death, if I have not disposed of any interest of mine in the Restricted
Shares by an outright bequest of the Restricted Shares to my spouse or domestic
partner, then the Company shall have the same rights against my legal
representative to exercise its rights to the Restricted Shares with respect to
any interest of mine in the Restricted Shares as it would have had pursuant to
the Award Agreement if I had acquired the Restricted Shares pursuant to a court
decree in domestic litigation.

     I AM AWARE THAT THE LEGAL, FINANCIAL AND RELATED MATTERS CONTAINED IN THE
AGREEMENT ARE COMPLEX AND THAT I AM FREE TO SEEK INDEPENDENT PROFESSIONAL
GUIDANCE OR COUNSEL WITH RESPECT TO THIS CONSENT. I HAVE EITHER SOUGHT SUCH
GUIDANCE OR COUNSEL OR DETERMINED AFTER REVIEWING THE AGREEMENT CAREFULLY THAT I
WILL WAIVE SUCH RIGHT.

  Dated as of the ________ day of _________________,200_.

Date: _________________________       /s/ Rosemary Sblendorio
                                      _____________________

                                      Rosemary Sblendorio
                                      _____________________
                                        Print Name
<PAGE>

                       CONSENT OF SPOUSE/DOMESTIC PARTNER

      I, Rosemary Sblendorio, spouse or domestic partner of Glenn Sblendorio,
acknowledge that I have read the RESTRICTED SHARE AWARD AGREEMENT dated as of
___________ (the "Award Agreement") to which this Consent is attached as Exhibit
A and that I know its contents. Capitalized terms used and not defined herein
shall have the meanings assigned to such terms in the Award Agreement. I am
aware that by its provisions the Restricted Shares granted to my spouse/domestic
partner pursuant to the Award Agreement are subject to forfeiture and that,
accordingly, I may be required to forfeit to Amicus Therapeutics, Inc. (the
"Company") any or all of the Restricted Shares of which I may become possessed
as a result of a gift from my spouse/domestic partner or a court decree and/or
any property settlement in any domestic litigation.

      I hereby agree that my interest, if any, in the Restricted Shares subject
to the Award Agreement shall be irrevocably bound by the Award Agreement and
further understand and agree that any community property interest I may have in
the Restricted Shares shall be similarly bound by the Award Agreement.

      I agree to the vesting and forfeiture provisions described in the Award
Agreement and I hereby consent to the forfeiture of the Restricted Shares to the
Company by my spouse/domestic partner or my spouse/domestic partner's legal
representative in accordance with the provisions of the Award Agreement.
Further, as part of the consideration for the Award Agreement, I agree that at
my death, if I have not disposed of any interest of mine in the Restricted
Shares by an outright bequest of the Restricted Shares to my spouse or domestic
partner, then the Company shall have the same rights against my legal
representative to exercise its rights to the Restricted Shares with respect to
any interest of mine in the Restricted Shares as it would have had pursuant to
the Award Agreement if I had acquired the Restricted Shares pursuant to a court
decree in domestic litigation.

      I AM AWARE THAT THE LEGAL, FINANCIAL AND RELATED MATTERS CONTAINED IN THE
AGREEMENT ARE COMPLEX AND THAT I AM FREE TO SEEK INDEPENDENT PROFESSIONAL
GUIDANCE OR COUNSEL WITH RESPECT TO THIS CONSENT. I HAVE EITHER SOUGHT SUCH
GUIDANCE OR COUNSEL OR DETERMINED AFTER REVIEWING THE AGREEMENT CAREFULLY THAT I
WILL WAIVE SUCH RIGHT.

  Dated as of the ___________ day of ________________________, 2007.

Date: ___________________________
                                         _______________________________________
                                         /s/ Rosemary Sblendorio
                                         _______________________________________
                                         Print Name Rosemary Sblendorio

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