Document:

Amendment No. 2, dated March 3, 2010, to the Rights Agreement

 Exhibit 4.1 
 AMENDMENT NO. 2 TO RIGHTS AGREEMENT 
 This
Amendment No. 2 to Rights Agreement (this “Amendment”), which is effective March 17, 2010, is by and between MDRNA, Inc. (f/k/a Nastech Pharmaceutical Company Inc.) (the “Company”), and American Stock
Transfer & Trust Company, LLC (the “Rights Agent”). Capitalized terms used in this Amendment but not otherwise defined herein shall have the meanings ascribed to such terms in the Rights Agreement (as defined in the
recitals below). 
 WHEREAS, the Company and the Rights Agent previously entered into that certain Rights Agreement dated
February 22, 2000 (the “Rights Agreement”) to provide for, among other things, certain preferred share purchase rights of the Company’s stockholders; and 
 WHEREAS, pursuant to Section 27 of the Rights Agreement, the Board of Directors of the Company (the “Board”) is
permitted to amend the Rights Agreement; and 
 WHEREAS, the Rights Agreement was previously amended by that certain
Amendment No. 1 to Rights Agreement entered into as of January 17, 2007; and 
 WHEREAS, pursuant to a
resolution duly adopted, the Board authorized and directed the execution and delivery of this Amendment; 
 NOW,
THEREFORE, in consideration of the rights and obligations contained herein, and for other good and valuable consideration, the adequacy of which is hereby acknowledged, the parties agree as follows: 
 1. Amendments to Section 1(c). Section 1(c)(ii) of the Rights Agreement is hereby amended by deleting the term
“or” at the end of the subsection. Section 1(c)(iii) of the Rights Agreement is hereby amended by deleting “Company.” at the end of such subsection and replacing it with “Company; or”. Section 1(c) of the
Rights Agreement is hereby amended by adding the following subsection (iv) to follow subsection (iii): 
 “(iv) which are the subject of a derivative transaction entered into by such Person or any of such Person’s Affiliates or Associates, or derivative security acquired by such Person or any of such Person’s Affiliates or
Associates, which gives such Person or any of such Person’s Affiliates or Associates the economic equivalent of ownership of an amount of such securities due to the fact that the value of the derivative is explicitly determined by reference to
the price or value of such securities, or which provides such Person or any of such Person’s Affiliates or Associates an opportunity, directly or indirectly, to profit, or to share in any profit, derived from any change in the value of such
securities, in any case without regard to whether (A) such derivative conveys any voting rights in such securities to such Person or any of such Person’s Affiliates or Associates, (B) the derivative is required to be, or capable of
being, settled through delivery of such securities, or (C) such Person or any of such Person’s Affiliates or Associates may have entered into other transactions that hedge the economic effect of such derivative. In determining the number
of shares of Common Stock of the Company

 
beneficially owned by virtue of the operation of this Section 1(c)(iv), the subject Person shall be deemed to beneficially own (without duplication) the notional or other number of shares of
Common Stock of the Company specified in the documentation evidencing the derivative position as being subject to be acquired upon the exercise or settlement of the applicable right or as the basis upon which the value or settlement amount of such
right, or the opportunity of the holder of such right to profit or share in any profit, is to be calculated in whole or in part, and in any case (or if no such number of shares of Common Stock of the Company is specified in such documentation or
otherwise), as determined by the Board of Directors in good faith to be the number of shares of Common Stock of the Company to which the derivative position relates.” 
 2. Amendment to Section 1(o). Section 1(o) of the Rights Agreement is hereby deleted in its entirety and replaced in its
entirety with the following: 
 “(o) “Expiration Date” shall mean the Close of Business on
March 17, 2013.” 
 3. Amendment to Section 26. The address information for the Rights Agent set forth in
Section 26 of the Rights Agreement is hereby deleted in its entirety and replaced in its entirety with the following: 
 American Stock Transfer & Trust Company, LLC 
 59 Maiden Lane 
 New York, NY 10038 
 In addition,
the address information for the Company set forth in Section 26 of the Rights Agreement is hereby deleted in its entirety and replaced in its entirety with the following: 
 MDRNA, Inc. 
 3830
Monte Villa Parkway 
 Bothell, Washington 98021 
 Attn: Chief Financial Officer 
 4. Amendments to Exhibits B and C to the Rights
Agreement. Exhibit B to the Rights Agreement (“Form of Right Certificate”) and Exhibit C to the Rights Agreement (Summary of Rights to Purchase Preferred Shares”) are hereby amended by deleting each reference therein
to “March 17, 2010” and substituting therefor “March 17, 2013”. 
 5. Full Force and Effect. Except
as expressly amended by this Amendment, the Rights Agreement shall remain in full force and effect, and all references to the Rights Agreement from and after such time shall be deemed to be references to the Rights Agreement as amended hereby. In
the event of any conflict, inconsistency or incongruity between any provision of this Amendment and any provision of the Rights Agreement, the provisions of this Amendment shall govern and control for purposes of the subject matter of this Amendment
only. This Amendment shall be construed in accordance with and as a part of the Rights Agreement, and all terms, conditions, representations, warranties, covenants and agreements set forth in the Rights Agreement and each other instrument or
agreement referred to therein, except as herein amended, are hereby ratified and confirmed. 

 6. Effectiveness. This Amendment shall be deemed effective as of the date first
written above as if executed on such date. 
 7. Governing Law. This Amendment shall be deemed to be a contract made
under the laws of the State of Delaware and for all purposes shall be governed by and construed in accordance with the laws of such state applicable to contracts to be made and performed entirely within such state. 
 8. Counterparts. This Amendment may be executed in any number of counterparts and each of such counterparts shall for all purposes be
deemed to be an original, and all such counterparts shall together constitute but one and the same instrument. 
 9.
Severability. The parties intend that this Amendment be enforced and interpreted as written. If, however, any term, provision, covenant or restriction of this Amendment is held by a court of competent jurisdiction or other authority to be
invalid, void or unenforceable, the remainder of the terms, provisions, covenants and restrictions of this Amendment shall remain in full force and effect and shall in no way be affected, impaired or invalidated. 
 10. Descriptive Headings. Descriptive headings of the several sections, subsections and provisions of this Amendment are inserted for
convenience of reference only and shall not control or affect the meaning, interpretation or construction of any of the terms or provisions hereof. 
 11. Stockholder Vote. The Board shall submit the Rights Agreement, as amended by this Amendment, for stockholder approval at an annual meeting of stockholders of the Company, or at a special
meeting of stockholders of the Company called for such purpose, on or before the first anniversary of the date of this Amendment. Notwithstanding any other provisions of this Amendment or the Rights Agreement, the Rights Agreement as amended by this
Amendment shall terminate upon the earlier of: (a) the close of business on March 17, 2013; (b) the close of business on the date of the annual or special meeting of stockholders of the Company at which the Rights Agreement as amended
by this Amendment was first submitted for stockholder approval and was not approved by the holders of a majority of the shares of the common stock of the Company represented at such meeting; or (c) the close of business on the first anniversary
of the date of this Amendment if the Rights Agreement, as amended by this Amendment, was not submitted for stockholder approval at an annual or special meeting of stockholders of the Company prior thereto. 
 [remainder of page intentionally left blank; signature page follows] 

 IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be
executed by their respective officers thereunto duly authorized as of this 3rd day of March, 2010. 
  

			
	MDRNA, INC.
		
	By:	 	 /s/ J. Michael French

	Name:	 	J. Michael French
	Title:	 	President and Chief Executive Officer
	
	 AMERICAN STOCK TRANSFER
 & TRUST COMPANY, LLC

		
	By:	 	 /s/ Paula Caroppoli

	Name:	 	Paula Caroppoli
	Title:	 	Vice PresidentFourth Amendment to Lease by Acquiport Unicorn, Inc. and Monotype Imaging, Inc.

 Exhibit 10.19 
 FOURTH AMENDMENT TO LEASE 
 THIS FOURTH AMENDMENT TO
LEASE, dated as of December 2, 2009 (this “Amendment”), between ACQUIPORT UNICORN, INC., a Delaware corporation (“Landlord”), and MONOTYPE IMAGING, INC., a Delaware corporation (“Tenant”), for certain
premises located in the building commonly known as 500 Unicorn Park Drive, Woburn, Massachusetts (the “Building”). 
 RECITALS: 
 A. Landlord and Tenant entered into that certain Gross Office Lease dated for reference
January 5, 2005, which was amended by that certain First Amendment To Lease dated January 26, 2005, by that certain Second Amendment to Lease dated as of May 26, 2006, and by that certain Third Amendment to Lease dated as of
March 4, 2008 (as amended, the “Lease”) for approximately 38,380 rentable square feet (the “Premises”) on the second floor of the Building. 
 B. Tenant and Landlord wish to adjust the rental obligations and extend the Term of the Lease, now scheduled to expire on February 28, 2011, upon terms and conditions as hereinafter set forth.

 C. All terms, covenants and conditions contained in this Amendment shall have the same meaning as in the Lease, and, shall
govern should a conflict exist with previous terms and conditions. 
 AGREEMENT: 
 NOW, THEREFORE, in consideration of the foregoing recitals and for other good and valuable consideration, the receipt and sufficiency of
which are hereby acknowledged, Landlord and Tenant hereby agree as follows: 
 1. Term. The Term of the Lease is hereby
extended and shall expire April 30, 2015, the new “Termination Date”. 
 2. Rent. From and after
January 1, 2010, Rent shall be payable in the following amounts, all of which are net of Tenant electricity: 
  

														
	Period	 	Rentable Square
Footage	 	Annual Rent
Per Square Foot	 	Annual Rent	 	Monthly Installment
of
Rent
	from	 	to	 	 	 	 
	1/1/2010	 	12/31/2010	 	38,380	 	$	20.75	 	$	796,385.00	 	$	66,365.42
	1/1/2011	 	12/31/2011	 	38,380	 	$	21.50	 	$	825,170.00	 	$	68,764.17
	1/1/2012	 	12/31/2012	 	38,380	 	$	22.25	 	$	853,955.00	 	$	71,162.92
	1/1/2013	 	12/31/2013	 	38,380	 	$	23.00	 	$	882,740.00	 	$	73,561.67
	1/1/2014	 	4/30/2015	 	38,380	 	$	23.75	 	$	911,525.00	 	$	75,960.42

 Provided that Tenant is not then
in default, the Monthly Installment of Rent will be abated for the period of January 1, 2010 through February 28, 2010. 
 3. Rent Adjustments. 
 (a) From and after January 1, 2010, Base Years for Expenses and
Insurance shall be the Calendar Year 2010. 
 (b) From and after January 1, 2010, Base Year for Taxes shall
be the Fiscal Year 2010 which commenced July 1, 2009 and ends June 30, 2010. 

 4. Condition of Premises. 
 (a) On or before January 1, 2010 or with due diligence thereafter, Landlord shall confirm or place all base Building
electrical, mechanical and plumbing systems in good working order. Otherwise and unless requested by Tenant as provided below, Tenant acknowledges that Landlord shall have no obligation to perform any construction or make any additional improvements
or alterations, or to afford any allowance (except as hereinafter provided) to Tenant for improvements or alterations, in connection with this Amendment. Tenant acknowledges and agrees that all construction and improvements obligations of Landlord
under the Lease, except as set forth in this provision, have been performed in full and accepted. Except as provided in this Section 4, Tenant takes the Premises during the extended Term in its “as is” condition. 
 (b) Tenant shall be entitled to an improvement allowance from Landlord towards (i) the cost of signage (as set forth in
Section 5 hereof), (ii) the cost of Tenant’s construction in the Premises, and (iii) architectural, engineering and construction management fees (i—iii collectively, “Tenant’s Work”) in the amount of up to
$191,000.00 (“Allowance”). If Tenant elects to have Landlord perform Tenant’s construction in the Premises, Landlord will do so and deduct its hard and soft costs from the Allowance. The Allowance (less any and all Landlord-incurred
hard and soft costs for performing any of Tenant’s Work pursuant to Tenant’s request) to Tenant is due and payable by Landlord not later than thirty (30) days after Tenant has satisfied all of the conditions in paragraph
(c) below, which conditions must be met on or before June 30, 2011. 
 (c) In the event Tenant performs
any or all of Tenant’s Work, as to the portion of Tenant’s Work performed by Tenant, Tenant shall provide to Landlord: (i) an architect’s certificate of final completion; (ii) copies of all necessary governmental permits,
including, but not limited to, a certificate of occupancy; (iii) the sworn statement of the general contractor; (iv) final lien waivers from all contractors, subcontractors and materialmen; and (v) any other information or
documentation reasonably requested by Landlord to evidence lien-free completion of construction and payment of all of the cost thereof. 
 5. Signage. Tenant shall be permitted to install one internally illuminated identification sign on the exterior north or south upper end portion of the Building facing Route 93 in accordance with
plans, specifications and specific location first approved by the Landlord. Tenant shall secure all necessary permits and comply will all applicable laws, codes and ordinances. At the expiration or earlier termination of the Term, Tenant shall
remove all such signage and repair any damage caused by such removal, all at Tenant’s sole cost and expense. 
 6.
Reference Pages Modifications. Landlord’s Address and Wire Instructions and/or Address for Rent Payment are hereby deleted and the following substituted in their place: 
 Landlord’s Address: 
 c/o Cushman & Wakefield of Massachusetts, Inc. 
 600 Unicorn Park Drive 
 Woburn, MA 01801

 Wire Instructions and/or Address for Rent Payment: 
 Wiring Information: 
 Bank Name: Bank of America 
 Bank ABA#: 026009593 
 Account Name:
Cushman & Wakefield of MA Inc AAF 
 Acquiport Unicorn Inc (Operating Acct) 
 Account Number: 385006940261 
  

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 Mailing Address: 
 Acquiport Unicorn, Inc. 
 P.O. Box 415503 
 Boston, MA 02241-5503 
 7.
Parking. The second sentence of the item labeled “Parking” on the Reference Pages of the Lease is amended, effective January 1, 2010, to read as follows: “Tenant shall have the right to use 23 reserved parking spaces in
the covered garage.” 
 8. Security Deposit. Effective January 1, 2010, the Security Deposit amount of
$207,280.00 shall be reduced by $64,954.16 to result in a total Security Deposit of $142,325.84. Landlord shall remit to Tenant the reduction amount of $64,954.16 within thirty (30) days from receipt by the parties hereto of this Amendment
fully executed. 
 9. Renewal Option. The renewal option as set forth in Article 37 of the Lease shall continue to be in
full force and effect during the Term as hereby extended; provided, however, the words “nine (9) months” in Section 37.1 shall be deleted and the words “twelve (12) months” shall be substituted in their place.

 10. Brokers. Landlord and Tenant each (i) represents and warrants to the other that it has not dealt with any
broker or finder in connection with this Amendment, except for Cushman & Wakefield which Broker shall be compensated by the Landlord per separate agreement and (ii) agrees to defend, indemnify and hold the other harmless from and
against any losses, damages, costs or expenses (including reasonable attorneys’ fees) incurred by such other party due to a breach of the foregoing warranty by the indemnifying party. 
 11. Incorporation. Except as modified herein, all other terms and conditions of the Lease shall continue in full force and effect and
Tenant hereby ratifies and confirms its obligations thereunder. Tenant acknowledges that as of the date of the Amendment, Tenant (i) is not in default under the terms of the Lease; (ii) has no defense, set off or counterclaim to the
enforcement by Landlord of the terms of the Lease; and (iii) is not aware of any action or inaction by Landlord that would constitute a default by Landlord under the Lease. 
 12. Tenant’s Authority. If Tenant signs as a corporation, Tenant represents and warrants that Tenant has been and is qualified
to do business in the state in which the Building is located, that the corporation has full right and authority to enter into this Amendment, and that all persons signing on behalf of the corporation were authorized to do so by appropriate corporate
actions. If Tenant signs as, a partnership, trust or other legal entity, each of the persons executing this Amendment on behalf of Tenant represents and warrants that Tenant has complied with all applicable laws, rules and governmental regulations
relative to its right to do business in the state and that such entity on behalf of the Tenant was authorized to do so by any and all appropriate partnership, trust or other actions. Tenant agrees to furnish promptly upon request a corporate
resolution, proof of due authorization by partners, or other appropriate documentation evidencing the due authorization of Tenant to enter into this Amendment. 
 Tenant hereby represents and warrants that neither Tenant, nor any persons or entities holding any legal or beneficial interest whatsoever in Tenant, are (i) the target of any sanctions program that
is established by Executive Order of the President or published by the Office of Foreign Assets Control, U.S. Department of the Treasury (“OFAC”); (ii) designated by the President or OFAC pursuant to the Trading with the Enemy Act, 50
U.S.C. App. § 5, the International Emergency Economic Powers Act, 50 U.S.C. §§ 1701-06, the Patriot Act, Public Law 107-56, Executive Order 13224 (September 23, 2001) or any Executive Order of the President issued pursuant to such
statutes; or (iii) named on the following list that

  

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is published by OFAC: “List of Specially Designated Nationals and Blocked Persons.” If the foregoing representation is untrue at any time during the Term, an Event of Default will be
deemed to have occurred, without the necessity of notice to Tenant. 
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 13. Limitation of Landlord Liability. Redress for any claim against Landlord under
this Amendment and the Lease shall be limited to and enforceable only against and to the extent of Landlord’s interest in the Building. The obligations of Landlord under this Amendment and the Lease are not intended to be and shall not be
personally binding on, nor shall any resort be had to the private properties of, any of its or its investment manager’s trustees, directors, officers, partners, beneficiaries, members, stockholders, employees, or agents, and in no case shall
Landlord be liable to Tenant hereunder for any lost profits, damage to business, or any form of special, indirect or consequential damages. 
 IN WITNESS WHEREOF, Landlord and Tenant have executed this Amendment as of the day and year first written above. 
  

									
	LANDLORD:	 		 	TENANT:
			
	 ACQUIPORT UNICORN, INC.,
 a Delaware corporation
	 		 	 MONOTYPE IMAGING, INC.,
 a Delaware corporation

					
	By:	 	

	 		 	By:	 	

	Name: 	 	Cavarly E.B. Garrett	 		 	Name: 	 	Douglas J. Shaw
	Title:	 	Vice President	 		 	Title:	 	President + CEO
					
	Dated:	 	December 7, 2009	 		 	Dated:	 	December 2, 2009

  

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