Document:

<PAGE>

                                                                   Exhibit 10.04

[***] indicates the omission of confidential portions for which confidential
treatment has been requested. Such confidential information has been filed
separately with the Commission.

                               SECOND AMENDMENT TO
                           WHOLESALE SUPPLY AGREEMENT

  ---------------------------------------------------------------------------

This second amendment ("SECOND AMENDMENT") dated June 2, 2004 amends the
Wholesale Supply Agreement dated January 1, 2004 ("AGREEMENT") and subsequently
amended on May 26, 2004 between CVS and Cardinal Health. CVS and Cardinal Health
("PARTIES") desire to enter into this Second Amendment to amend Section 1 and
Section 12 Disclosure Schedule [***].

The Parties agree as follows:

     1.   Effective Date of Amendment. This Second Amendment shall be effective
          as of [***]. In the event that the [***] does not [***], then this
          Second Amendment shall become null and void and shall be of no force
          or effect. Furthermore, CVS reserves the right to provide Cardinal
          with notification ("NOTICE") before the close of the [***] that CVS
          has determined in its sole discretion that it will not undertake the
          wholesale supply arrangement as described in the Second Amendment in
          which case this Second Amendment shall become null and void and shall
          be of no force or effect.

     2.   Scope. Notwithstanding anything else in the Agreement, as amended, in
          no event will CVS, at any time, be obligated to designate [***] by CVS
          or its affiliates for any reason, or which, [***] by CVS or its
          affiliates in its business judgment, [***], or [***].

     3.   Disclosure Schedules. The Agreement is amended by deleting therefrom
          the following disclosure schedules in their entirety:

                  "Section 1", and
                  "Section 12 Disclosure Schedule"

          and replacing them with the following new Disclosure Schedules:

                  "Section 1", and
                  "Section 12 Disclosure Schedule"

          attached to this Second Amendment and incorporated into this Second
          Amendment and into the Agreement by this reference, which shall be
          attached by the Parties to their respective copies of the Agreement.

     4.   Generally. It is the Parties' intent for the Agreement and this
          Amendment [***] to be applied and construed as a single instrument.
          The Agreement, as modified by this Second Amendment, remains in full
          force and effect and constitutes the entire agreement

<PAGE>

          among the Parties regarding this subject matter and supersedes all
          prior or contemporaneous writings and understandings among the Parties
          with respect thereto. This Second Amendment will be binding on the
          Parties and their successor and assigns. If any term or provision of
          this Second Amendment is determined to be illegal or unenforceable by
          a court of competent jurisdiction, the remaining terms and provisions
          of this Second Amendment and the Agreement will remain in full force
          and effect. Only a subsequent writing signed by both Parties may amend
          this Second Amendment or further amend the Agreement.

CVS Pharmacy, Inc                         Cardinal Health*

By: /s/ Matthew J. Leonard                By: /s/ Michael J. Bender
    ----------------------------              ----------------------------------
Print Name: Matthew J. Leonard            Print Name: Michael J. Bender
            --------------------                      --------------------------
Title: VP Pharmacy Merchandising          Title: EVP, Retail Sales and Marketing
       -------------------------                 -------------------------------

*The term "CARDINAL HEALTH" means the following pharmaceutical distribution
companies: Cardinal Health 106, Inc. (formerly known as James W. Daly, Inc.), a
Massachusetts corporation (Peabody, Massachusetts); Cardinal Health 103, Inc.
(formerly known as Cardinal Southeast, Inc.), a Mississippi corporation
(Madison, Mississippi); Cardinal Health 110, Inc. (formerly known as Whitmire
Distribution Corporation), a Delaware corporation (Folsom, California) and any
other subsidiary of Cardinal Health, Inc., an Ohio corporation ("CHI"), as may
be designated by CHI.

Cc:    Tina Egan, Assistant General Counsel CVS
       Paul Williams, General Counsel Cardinal Health

                                       2
<PAGE>

                                                                       SECTION 1
                                                                       ---------
                                                            AMENDED JUNE 2, 2004
                                                            --------------------

SECTION 1.   DESIGNATION AS  [***].
             ----------------------

         (a) Retail Pharmacies. During the term of this Agreement, CVS will
         designate Cardinal as [***] operated by CVS (collectively, the
         "PHARMACIES" and individually, a "PHARMACY") subject to Section 1(a)
         Disclosure Schedule. A list of the Pharmacies (the "[***]") will be
         provided by CVS to Cardinal from time to time during the term of this
         Agreement.

         (b) Distribution Centers. During the term of this Agreement, CVS will
         designate Cardinal as [***] operated by CVS ("CVS PHARMACY DCS")
         subject to Section 1(b) Disclosure Schedule. A comprehensive list [***]
         as of January 1, 2004 (the date of this agreement) (the "Total DC
         List") is set forth in the Section 1(b) Disclosure Schedule.

         (c) [***]. This Agreement [***] purchases which are made by CVS on
         behalf of the CVS [***] In return [***] as described in the Section 12
         Disclosure Schedule, CVS will [***] from a CVS Pharmacy DC being
         serviced by Cardinal for a period of [***]. If at anytime after [***],
         CVS [***] from a CVS Pharmacy DC being serviced by Cardinal, then s
         described in the Section 12 Disclosure Schedule will [***]. If CVS
         [***] from a CVS Pharmacy DC being serviced by Cardinal after the
         [***], then the [***] as described in the Section 12 Disclosure
         Schedule will for as long as CVS [***] from a CVS Pharmacy DC being
         serviced by Cardinal.

         This Agreement specifically excludes [***] on behalf of the [***].

         As it concerns [***], in the event either party desires not to [***]
         from a [***] being serviced by Cardinal at the expiration of the First
         Term or any renewal term, that party shall provide the other party with
         at least [***] notice prior to the expiration of the then current term.
         In the event such notification is not provided with at least the [***]
         notice or if no notice is given, the then current term shall be [***]
         for a period of [***] after the expiration of such term to provide for
         [***].

         (d) CVS Commitment. This Agreement pertains only to [***] Pharmacies.

                                       3
<PAGE>

                                                  SECTION 12 DISCLOSURE SCHEDULE
                                                  ------------------------------
                                                            AMENDED JUNE 2, 2004
                                                            --------------------

                                      [***]

The goal of the [***] is to [***] under which Cardinal will [***] which are or
become part of this Agreement. The parties agree and acknowledge that this [***]
is part of this Agreement, and is not a separate or distinct agreement.

Notwithstanding anything in this Agreement to the contrary, the [***].

The [***] is designed to [***].  CVS will [***].

As part of the [***], Cardinal will [***] (in addition to [***] for the
respective [***] during the term of this Agreement. The [***] will be faxed and
subsequently mailed in hard copy form to CVS' Manager of Wholesaler Programs.
Additionally, Cardinal will [***] with the [***] detailed in Section 2(b)
Disclosure Schedule [***]. In return for [***] and the [***], Cardinal will
[***] through certain [***] as defined below.

[***] as of the execution of this Agreement with the exception of [***] (as
detailed in and subject to Section 12 Disclosure Schedule). Cardinal will
[***]. In return for [***] from [***] until [***] by [***], Cardinal will
[***]"). The timing of [***].

CVS will not be required to [***] sole determination. The [***] Exhibit below
details [***] CVS will [***] (subject to Section 12 Disclosure Schedule) and the
corresponding [***] to be amended in writing pursuant to Section 13 upon mutual
agreement of CVS and Cardinal. While CVS and Cardinal may both agree that it is
in the best interest of both parties to [***] and will occur at [***].

CVS is under no obligation to [***] at its sole discretion. With that said, CVS
and Cardinal may [***] sole discretion. So that Cardinal and CVS can [***],
Cardinal will provide to CVS in an electronic format a detailed weekly report
detailing said [***]. The [***] will include but not be limited to the following
elements as it pertains to Cardinal [***]. As it pertains to [***] Report only,
Cardinal will [***]. All other data elements will be updated [***] and
immediately sent to CVS [***] accurately representing Cardinal's [***] available
to CVS as of the creation of the [***].

[***]
-----

For all of [***] etc, CVS will [***] within [***] of the end of each CVS fiscal
quarter in the form of [***] (in addition to [***]) [***] during the term of
this Agreement. [***]. CVS and Cardinal will agree with [***].

For example; [***], then Cardinal will [***].

Further terms and conditions of the [***] are as follows:

                                       4
<PAGE>

     1)   CVS and Cardinal will [***]; within [***] of the respective CVS fiscal
          month's end or as soon as practical.

     2)   The [***] will not be applied [***]. The [***] will be automatically
          applied [***].

     3)   CVS contract pricing on [***].

     4)   The [***] is based on the assumption that Cardinal will not [***].

     5)   Cardinal will not [***]. However, Cardinal will [***].
               a.   [***].
               b.   [***].
               c.   [***].

     6)   At the start of this Agreement, Cardinal will [***]. To that end, CVS
          and Cardinal have agreed that [***] under this Agreement.

     7)   [***] For example, if [***].

     8)   For all [***].

     9)   If CVS [***] then Cardinal will not [***].

     10)  If CVS [***] (as defined below) [***], then Cardinal will not [***].

[***]
-----

As a function of the [***] Cardinal will [***] as defined below. Through the
[***], Cardinal will [***] as further defined below. Notwithstanding anything
else in this Agreement to the contrary, Cardinal will [***].

The "[***]" for the [***] are limited to:

         [***].

         [***].

         [***].

Further terms and conditions of the [***] are as follows:

1)   CVS will [***]; CVS will not be required to [***].

2)   CVS [***] to include but not limited to:
         [***]
         [***]
         [***]
         [***]

                                       5
<PAGE>

3)   [***] In the event that [***] (Pharmacies and CVS Pharmacy DCs, if
     applicable). Notwithstanding the foregoing, Cardinal will [***] It will be
     [***] sole responsibility to notify [***] in writing (with copy to [***]
     subject to Section 13) [***] related to [***].

4)   CVS will only accept product [***] to CVS Pharmacy DCs that has at least
     [***]. All products shipped with less than [***] will be considered
     "[***]". On an exception basis, CVS will [***] with at least [***].
     However, both parties agree that no more than [***]. In addition, upon CVS
     request (as often as monthly), Cardinal will provide CVS [***]. The [***]
     will contain all [***] and will [***] (both CVS and Cardinal agree that the
     [***] will be made available to CVS no later than September 1, 2004).
     Notwithstanding anything in this Agreement to the contrary, at no time will
     Cardinal ship [***] with less than [***] to CVS Pharmacy DCs. With that
     said, CVS will [***].

Additional terms and conditions of the [***] are as follows:

1.   Term - The [***] will commence as of [***], and terminate upon [***].

2.   [***] - Cardinal will [***].

3.   [***] - If Cardinal's [***], and if CVS is [***], then CVS will, upon
     request by Cardinal, [***]. With respect to the foregoing [***], CVS will
     [***]. CVS will [***].

               (a) [***] On the same day as CVS receives a shipment of [***]
          ordered as part of a [***] related to this [***], CVS will [***].
          Cardinal will [***]. CVS will [***], and CVS will [***] based on the
          applicable payment terms. CVS will [***], and Cardinal will [***].
          The process outlined in the Section 2(b) Disclosure Schedule will
          apply to any discrepancies.

               (b) [***] As it pertains to [***] purchases only, on the same day
          as CVS receives the shipment of [***].

     As it pertains to the payment of [***], Cardinal will receive an invoice
     from the applicable manufacturer for the ordered Rx Product, and Cardinal
     will [***], based on the applicable payment terms. As the [***] for such
     [***] in accordance with the terms of this Agreement. The process outlined
     in the Section 2(b) Disclosure Schedule will apply to any discrepancies.

4.   Purchase Information - CVS will provide Cardinal with [***] on behalf of
     the CVS Pharmacy DCs pursuant to the [***]. Such information will include
     details regarding all [***] and other information reasonably required by
     Cardinal to administer the [***]. To assist Cardinal with [***] CVS will
     provide Cardinal with information reasonably requested by Cardinal
     including but not limited to [***], and a change in CVS Pharmacy DC that
     services a particular Pharmacy.

5.   Limitations - All [***]. All [***]. CVS will not [***] (outside of this
     [***]) on behalf of the Pharmacies. It is understood and agreed that
     Cardinal will not [***]. Furthermore, the parties acknowledge and agree
     that all information

                                       6
<PAGE>

     associated with the [***] is confidential information subject to the
     provisions of Section 17 of this Agreement.

6.   Records, Audit and Confidentiality - The [***] is subject to the record
     keeping and audit provisions set forth in Section 16 of this Agreement.
     Cardinal may [***]. Cardinal will notify CVS in writing (subject to Section
     13) prior to the [***]. Further, Cardinal will use reasonable efforts to
     [***] CVS if needed.

7.   [***] - All payments for invoicing under the [***] will be made via [***].

8.   Waiver - [***]

9.   [***] Relating to the [***] - CVS and Cardinal acknowledge that either
     party may from time to time may, in good faith, [***]. In the event that
     either party [***], each party agrees to use all reasonable efforts to
     resolve all such [***] as expeditiously as possible on a fair and equitable
     basis. To that end, Cardinal and CVS will assemble a panel consisting of
     [***] (the "EXECUTIVE COMMITTEE") to resolve [***] and address other issues
     as they may determine. With respect to [***], a copy of the terms of this
     Agreement, as amended from time to time, agreed upon facts and [***], and a
     concise summary of the basis for each side's contentions will be provided
     to the executives who will review the same, confer, and attempt to reach a
     mutual resolution of the issue within [***] following either party's
     receipt of notice of [***].

                                       7
<PAGE>

[***] EXHIBIT.
--------------

          [***]                 [***]
------------------------------------------------
     [***]                      [***]

                                       8<PAGE>

                                                                   Exhibit 10.06

[***] indicates the omission of confidential portions for which confidential
treatment has been requested. Such confidential information has been filed
separately with the Commission.

                               SECOND AMENDMENT TO
                             PRIME VENDOR AGREEMENT

         THIS SECOND AMENDMENT TO PRIME VENDOR AGREEMENT ("SECOND AMENDMENT") is
among Cardinal Health*, formerly known as Cardinal Distribution, ("CARDINAL"),
and Express Scripts, Inc. ("BUYER").

         WHEREAS, Cardinal and Buyer executed a Prime Vendor Agreement, dated
July 1, 2001 (the "AGREEMENT"), and executed a First Amendment to Prime Vendor
Agreement, dated January ___, 2003 ("FIRST AMENDMENT").

         WHEREAS, the parties desire to further amend the Agreement, as amended,
to reflect the terms of a new returned goods policy for unmerchantable product.

         NOW THEREFORE, in consideration of the foregoing recitals, the parties
hereby agree as follows:

     1. RETURNED GOODS POLICY FOR UNMERCHANTABLE PRODUCT. Attached as EXHIBIT A
and incorporated herein by reference is a returned goods policy for
unmerchantable product, which describes a return process whereby Cardinal will
assist Buyer in receiving value for certain unmerchantable product.

     2. MISCELLANEOUS. Capitalized terms not defined herein will have the same
meaning ascribed to them in the Agreement, as amended by the First Amendment, it
being the intent of the parties that the Agreement, as amended by the First
Amendment, and this Second Amendment will be applied and construed as a single
instrument. The Agreement, as amended by the First Amendment and as modified by
this Second Amendment, constitutes the entire agreement between Cardinal and
Buyer regarding the subject matter of the Agreement, as amended by the First
Amendment, and this Second Amendment and supersedes all prior or contemporaneous
writings and understandings between the parties regarding the same. This Second
Amendment will be binding upon the parties, their heirs, legal representatives,
successors and assigns. The terms and provisions of this Second Amendment are
severable. If any term or provision of this Second Amendment is determined to be
illegal or unenforceable by a court of competent jurisdiction, the remaining
terms and provisions of this Second Amendment and the Agreement, as amended by
the First Amendment will remain in full force and effect. This Second Amendment
may only be amended in a writing signed by Cardinal and Buyer.

     3. EFFECTIVE DATE. This Second Amendment shall be effective as of the date
of full execution ("EFFECTIVE DATE"). Except as otherwise amended herein, the
terms and conditions of the Restated Agreement shall remain in full force and
effect.

CARDINAL HEALTH*                            EXPRESS SCRIPTS, INC.

BY:    /s/ John E. Grimm                    BY:    /s/ George Paz
       -------------------------------             -----------------------------

NAME:  John E. Grimm                        NAME:  George Paz
       -------------------------------             -----------------------------

TITLE: SVP, Alternate Care                  TITLE: President
       -------------------------------             -----------------------------

DATE:  11-19-03                             DATE:  11/12/03
       -------------------------------             -----------------------------

*The term "CARDINAL HEALTH" means the following pharmaceutical distribution
companies including: Cardinal Health 106, Inc. (formerly known as James W. Daly,
Inc.), a Massachusetts corporation (Peabody, Massachusetts); Cardinal Health
103, Inc. (formerly known as Cardinal Southeast, Inc.), a Mississippi
corporation (Madison, Mississippi); Cardinal Health 110, Inc. (formerly known as
Whitmire Distribution Corporation), a Delaware corporation (Folsom, California)
and any other subsidiary of Cardinal Health, Inc., an Ohio corporation ("CHI"),
as may be designated by CHI.

<PAGE>

                                                                       EXHIBIT A

                RETURNED GOODS POLICY FOR UNMERCHANTABLE PRODUCT

Cardinal and Buyer have agreed to pursue a return process whereby Cardinal will
assist Buyer in receiving value for certain unmerchantable Product. Product
which may not be returned pursuant to Cardinal's Standard Returned Goods Policy
may be returned to an authorized manufacturer through a third party pursuant to
this policy. Products which are "UNMERCHANTABLE" include, but are not limited
to, those items which Cardinal determines are not in "merchantable condition"
(as defined in Cardinal's Returned Goods Policy), and the following:

A. Any item which has been used or opened, is a partial dispensing unit or unit
of sale, is without all original packaging, labeling, inserts or operating
manuals, or that is stickered, marked, damaged, defaced or otherwise cannot
readily be resold by Cardinal for any reason.

B. Short-dated (less than seven (7) months expiration dating), outdated, or
seasonal product and items purchased on a "special order" basis, including
non-stock and drop ship items.

C. Any sterile or refrigerated Merchandise, unless Cardinal is specially assured
that such Merchandise was properly stored and protected at all times and such
Merchandise is returned separately in a package marked as such and accompanied
by a separate credit request form.

D. Any low stability product, including Epogen(TM), Eminase(TM), or other
products which are usually sensitive to temperature and handling conditions.

E. Any product not intended for return to a wholesaler in accordance with the
return policies of the applicable manufacturer.

Product in "unmerchantable condition" may generally be returned to vendors (a)
with which Cardinal has a current relationship, (b) are not either insolvent or
subject to a petition in bankruptcy, or (c) which do not have an outstanding
balance due Cardinal at the date on which such Product is submitted for return
(each such vendor, an "ACTIVE MANUFACTURER"). Unmerchantable Product may only be
returned through a third party return processor ("THIRD PARTY") in accordance
with the terms and conditions described in this policy. Cardinal will provide
the Third Party selected by Buyer with a current list of all Active
Manufacturers. Any Third Party selected by Buyer must enter into a
Confidentiality Agreement, in a form acceptable to Cardinal, prior to accepting
any returns from Buyer.

                             PROCEDURES FOR RETURNS

Buyer and Cardinal will notify each Active Manufacturer of their relationship as
customer/wholesaler. Buyer will send all returns of unmerchantable Product to
its selected Third Party. The amount identified by the Third Party as the amount
to which Buyer is entitled in exchange for the return will be determined in
accordance with the return policy of the applicable Active Manufacturer as
described in the Third Party's database, which will reflect Buyer's cost of
goods purchased through Cardinal. Buyer will instruct the Third Party to provide
Cardinal with documentation (either in paper or electronic format) to
substantiate each debit memo submitted to Active Manufacturers on behalf of
Buyer.

Buyer will instruct each Active Manufacturer to issue any and all credits to
Cardinal for Merchandise that was purchased by Buyer from Cardinal and is
returned through a Third Party in unmerchantable condition, and to reference the
debit memo number corresponding to the debit memo prepared by the Third Party.
Buyer and Cardinal acknowledge that Buyer will handle, without Cardinal's
involvement, all matters relating to returns to manufacturers with which Buyer
has a direct contracting relationship (whether or not such manufacturer is an
Active Manufacturer).

Buyer will pay the Third Party directly for all of such Third Party's fees. In
addition, Buyer will reimburse Cardinal for all costs billed by the Third Party
to Cardinal that relate to Buyer's returns hereunder, including, but not limited
to, processing fees, postage, delivery and destruction fees.

                                       2
<PAGE>

Cardinal will be paid [***]% of the net returns received by Cardinal from all
Active Manufacturers as a processing fee (the "PROCESSING FEE") in accordance
with the following procedure:

         (1) Cardinal will adjust Buyer's account upon the earlier of receipt of
an actual credit from an Active Manufacturer, or within sixty (60) days
following the date of a debit memo submitted to an Active Manufacturer. Buyer
will not deduct from any UNAUTHORIZED amounts owed to Cardinal, any UNAUTHORIZED
amounts relating to the return of Merchandise through a Third Party.

         (2) Each calendar month, Cardinal will (a) track credits due Buyer's
account in the amount received by Cardinal from each Active Manufacturer during
such month for Buyer returns (or, if not received within sixty (60) days, the
amount anticipated to be received as shown on the debit memo), and (b) adjust
previously made credits to Buyer's account to reflect actual credits authorized
to Cardinal for returned Product, so that a net credit may be determined.

         (3) Within five (5) business days after the end of the previous
calendar month, Cardinal will credit Buyer's account with the net amount due
Buyer for all Third Party Returns activities during the previous month, less the
Processing Fee.

With the monthly credit, Cardinal will provide Buyer with a report of all Active
Manufacturer credits and debit memos posted during such month. Cardinal will not
perform a detail line reconciliation of the amounts authorized by Active
Manufacturers as compared to the original debit memo.

Notwithstanding the foregoing, if the applicable Active Manufacturer (a) is in a
debit balance in Cardinal's accounts payable system, or (b) is subject to a
petition in bankruptcy or is deemed insolvent, then no credit will be issued to
Buyer, and the credit will accrue to Cardinal's benefit, until such time as the
Active Manufacturer is no longer in a debit balance, bankruptcy proceeding or
insolvent. In addition, the Third Party will be exclusively responsible for
resolving discrepancies relating to returned Product through such Third Party.

To the extent that Buyer desires to return Product to a supplier which is not an
approved Active Manufacturer, Cardinal will credit Buyer's account only after
Cardinal receives payment either through check, money order or wire transfer. If
check, wire transfer or any other payment method is employed which does not
guarantee Cardinal immediately available funds, Cardinal will credit Buyer's
account only upon receiving such funds in Cardinal's account. Buyer may not
offset payments due from Buyer to Cardinal for Product purchases against any
amounts Buyer deems are due and owing pursuant to this Third Party Returned
Goods Policy.

Cardinal may modify this Third Party Returned Goods Policy in its reasonable
discretion from time to time. The Buyer is to be notified within thirty (30)
days of a modification and such modification is subject to mutual agreement.

                                       3

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