Document:

<PAGE>   1
                                                                   Exhibit 10.22

                           FOURTH AMENDMENT TO LEASE
                           -------------------------

     FOURTH AMENDMENT TO LEASE dated as of this 28th day of August, 2000 by
and between BOSTON PROPERTIES LIMITED PARTNERSHIP, a Delaware limited
partnership ("Landlord") (as successor-in-interest to 200 West Street Limited
Partnership) and PAREXEL INTERNATIONAL CORPORATION, a Massachusetts corporation
("Tenant").

                                    RECITALS
                                    --------

     WHEREAS, by lease dated June 14, 1991 (as amended by the First Amendment,
Second Amendment and Third Amendment referred to below, the "Lease"), Landlord
did lease to Tenant and Tenant did hire and lease from Landlord certain premises
in the building known as and numbered 195 West Street, Waltham, Massachusetts
(the "Building") containing a total of 48,258 square feet of rentable floor area
(hereinafter sometimes referred to as the "Initial Premises").

     WHEREAS, by First Amendment to Lease dated January 3, 1992 (the "First
Amendment"), Tenant exercised its right pursuant to Section 2.1.1.1 of the
Lease to lease from landlord an additional 15,242 square feet of rentable floor
area in the Building (the "Additional Premises") upon the terms and conditions
contained in the First Amendment. The Initial Premises and the Additional
Premises are hereinafter sometimes collectively referred to as the "Premises".

     WHEREAS, by Second Amendment to Lease dated June 28, 1993 (the "Second
Amendment"), Tenant leased from Landlord an additional 660 square feet in the
basement of the Building (the "Tenant's Storage Space") upon the terms and
conditions contained in the Second Amendment.

     WHEREAS, by Third Amendment to Lease dated November 17, 1998 (the "Third
Amendment"), Landlord provided Tenant with the option of extending the Term of
the Lease so that it would be coterminus with the 200 West Street Lease Term (as
that term is defined in the Third Amendment).

     Landlord and Tenant have agreed to extend the Term of the Lease for the
Interim Extended Term (as that term is defined in the Third Amendment), and are
entering into this instrument to so extend the Term of the Lease and to amend
the Lease.

     NOW, THEREFORE, in consideration of One Dollar ($1.00) and other good and
valuable consideration in hand this date paid by each of the parties to the
other, the receipt and sufficiency of which are herby severally acknowledged,
and in further consideration of the mutual promises herein contained, Landlord
and Tenant herby agree to and with each other as follows:

     1.   (A) The Term of the Lease, which but for this Fourth Amendment is
scheduled to expire on August 31, 2001, is hereby extended for one (1) period of
seven (7) years and eight

                                      -1-
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(8) months commencing on September 1, 2001 and expiring on April 30, 2009 (the
"Interim Extended Term") unless sooner terminated in accordance with the
provisions of the Lease, upon all the same terms and conditions contained in
the Lease as herein amended.

          (B) Upon the expiration of the Interim Extended Term, Tenant shall
have the right to further extend the Term of the Lease for two (2) additional
periods of five (5) years each (each such option being sometimes hereinafter
referred to as an "Extended Term") upon all the terms and conditions set forth
in Section 2.4.1 of the Lease. Notwithstanding anything contained herein to the
contrary, in no event shall Tenant have the right to exercise more than one
extension option at a time and, further, Tenant shall not have the right to
exercise its second extension option unless it has duly exercised its first
extension option and in no event shall the Lease Term be extended for more than
ten (10) years after the expiration of the Interim Extended Term.

     2.   (A) Prior to the commencement of the Interim Extended Term, Annual
Fixed Rent shall continue to be payable as set forth in the Lease.

          (B) During the period from September 1, 2001 through August 31, 2003,
Annual Fixed Rent shall be payable by Tenant at the annual rate of
$2,832,350.00, being the sum of $2,825,750.00 (being the product of (x) $44.50
and (y) the Rentable Floor Area of the Premises [being 63,500 square feet]) and
$6,600.00 (being the product of (x) $10.00 and (y) the Rentable Floor Area of
Tenant's Storage Space [being 660 square feet]).

          (C) During the period from September 1, 2003 through August 31, 2005,
Annual Fixed Rent shall be payable by Tenant at the annual rate of
$2,895,850.00, being the sum of $2,889,250.00 (being the product of (x) $45.50
and (y) the Rentable Floor Area of the Premises) and $6,600.00 (being the
product of (x) $10.00 and (y) the Rentable Floor Area of Tenant's Storage
Space).

          (D) During the period from September 1, 2005 through August 31, 2007,
Annual Fixed Rent shall be payable by Tenant at the annual rate of
$2,959,350.00, being the sum of $2,952,750.00 (being the product of (x) $46.50
and (y) the Rentable Floor Area of the Premises) and $6,600.00 (being the
product of (x) $10.00 and (y) the Rentable Floor Area of Tenant's Storage
Space).

          (E) During the period from September 1, 2007 through April 30, 2009,
Annual Fixed Rent shall be payable by Tenant at the annual rate of
$3,054,600.00, being the sum of $3,048,000.00 (being the product of (x) $48.00
and (y) the Rentable Floor Area of the Premises) and $6,600.00 (being the
product of (x) $10.00 and (y) the Rentable Floor Area of Tenant's Storage
Space).

          (F) Annual Fixed Rent for the Premises and Tenant's Storage Space
during the Extended Terms (if exercised) shall be determined as provided in
Section 2.4.1 of the Lease (as amended hereby).

                                      -2-
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     3. (A) For the purposes of computing the Tenant's payments for Operating
Expenses Allocable to the Premises during the Interim Extended Term pursuant to
Section 2.6 of the Lease (as amended by Section 6 of the First Amendment), the
definition of "Base Operating Expenses" contained in said Section 2.6 shall be
deleted in its entirety and replaced with the following:

     "'Base Operating Expenses' shall mean Landlord's Operating Expenses for
     calendar year 2001, being the period from January 1, 2001 through December
     31, 2001."

     (B) For the purposes of computing Tenant's payments for Landlord's Tax
Expenses Allocable to the Premises during the Interim Extended Term pursuant to
Section 2.7 of the Lease (as amended by Section 6 of the First Amendment), the
definition of "Base Taxes" contained in said Section 2.7 shall be deleted in its
entirety and replaced with the following:

     "'Base Taxes' shall mean Landlord's Tax Expenses for fiscal tax year 2002,
     being the period from July 1, 2001 through June 30, 2002."

     (C) For the portion of the Lease Term prior to the commencement of the
Interim Extended Term, the definitions of Base Operating Expenses and Base Taxes
shall remain unchanged for such purposes.

     (D) Effective as of September 1, 2001, Sections 2.6.1 and 2.9 of the Lease
are hereby deleted in their entirety and shall be deemed null and void and of no
further force and effect.

     4. (A) It is understood and agreed that Tenant shall be undertaking certain
renovation work in the Premises (the "Tenant Improvement Obligations"), as shown
on and consistent with certain construction drawings to be submitted by Tenant
and reviewed by Landlord in accordance with the terms and provisions of the
Lease. Tenant hereby covenants and agrees, at its sole cost and expense and in
accordance with the terms and provision of this Lease, to initiate and
thereafter diligently prosecute to completion the Tenant Improvement
Obligations. Tenant further acknowledges and agrees that Landlord shall have no
obligation to perform any potion of the Tenant Improvement Obligations, all of
such work being the sole responsibility of Tenant hereunder.

     (B) Landlord shall provide to Tenant an allowance $508,000.00 (the "Tenant
Allowance") to be applied towards the cost of the Tenant Improvement Obligations
(including, without limitation, the architect's fee in connection therewith, but
excluding items of a movable nature, such as systems furniture or other items
that will not remain in the premises upon the expiration of the Lease Term). In
addition, Tenant shall be entitled to apply up to $254,000.00 of the Tenant
Allowance towards the costs of tenant improvements to be undertaken by Tenant in
its premises at the 200 West Street building (subject to the same limitations as
set forth in the first sentence of this subsection (B)). It is understood and
agreed that the Tenant Allowance (or portions thereof) will be made available to
Tenant within thirty (30) days after Tenant provides Landlord with invoices
showing the actual cost of performing the applicable portion of the Tenant
Improvement Obligations, and that such disbursement may occur at any time after
the execution of this Fourth Amendment regardless of whether or not the Extended

                                      -3-

<PAGE>   4
Term has commenced at such time. To the extent the costs of the Tenant
Improvement Obligations exceed the Tenant Allowance, Tenant shall be solely
responsible for such excess costs and shall promptly pay the difference to the
appropriate contractors and suppliers.

     (C) Notwithstanding the foregoing, Landlord shall be under no obligations
to apply any portion of the Tenant Allowance for any purposes other than as
provided in this Section 4, nor shall Landlord be deemed to have assumed any
obligations, in whole or in part, of Tenant to any contractors, subcontractors,
suppliers, workmen or materialmen. In addition, Landlord shall not be obligated
to make any application of any portion of the Tenant Allowance (i) for so long
as (x) there shall be an existing default of Tenant or (y) there are any liens
which are not bonded to the reasonable satisfaction of Landlord against Tenant's
interest in the Lease or against the Building or the Site arising out of any
work performed by Tenant or any litigation in which Tenant is a party or (ii) to
the extent not requested by Tenant prior to September  1, 2003. Further, in no
event shall Landlord be required to make application of any portion of the
Tenant Allowance on account of any supervisory fees, overhead, management fees
or other payments to Tenant, or any partner or affiliate of Tenant.

     5.  (A) Tenant warrants and represents that Tenant has not dealt with any
broker in connection with the consummation of this Fourth Amendment other than
Trammell Crow Company (the "Broker"); and in the event any claim is made against
Landlord relative to dealings by Tenant with brokers other than the Broker,
Tenant shall defend the claim against Landlord with counsel of Tenant's
selection first approved by Landlord (which approval shall not be unreasonably
withheld) and save harmless and indemnify Landlord on account of any loss, cost
or damage which may arise by reason of such claim.

         (B) Landlord warrants and represents that Landlord has not dealt with
any broker in connection with the consummation of this Fourth Amendment other
than the Broker; and in the event any claim is made against Tenant relative to
dealings by Landlord with brokers other than the Broker, Landlord shall defend
the claim against Tenant with counsel of Landlord's selection first approved by
Tenant (which approval shall not be unreasonably withheld) and save harmless and
indemnify Tenant on account of any loss, cost or damage with may arise by reason
of such claim. Landlord agrees that it shall be solely responsible for the
payment of the brokerage commission to the Broker in connection with this Fourth
Amendment.

     6.  Except as otherwise expressly provided herein, all capitalized terms
used herein without definition shall have the same meaning as set forth in the
Lease.

     7.  Except as herein amended the Lease shall remain unchanged and in full
force and effect. All references to the "Lease" shall be deemed to be references
to the Lease as heretofore amended and as amended hereby.

                                      -4-

<PAGE>   5
     EXECUTED as a sealed instrument as of the date and year first above
written.

WITNESS:                       LANDLORD:

/s/ J.H. Howard                BOSTON PROPERTIES LIMITED
--------------------
                               By: Boston Properties, Inc., its General Partner

                               By: Claude B. Hoopes
                                  ----------------------------------------
                               Name: Claude B. Hoopes
                                    --------------------------------------
                               Title: Senior Vice President
                                     -------------------------------------

ATTEST:                        TENANT:

/s/ Mark T. Beaudouin          PAREXEL INTERNATIONAL CORPORATION
---------------------

By                              By /s/ Josef H. von Rickenbach
  ------------------              -----------------------------------------
Name Mark T. Beaudouin          Name  Josef H. von Rickenbach
    ------------------              ---------------------------------------
Title Clerk                     Title Chairman, President and CEO
     ----------------                --------------------------------------
                                     HEREUNTO DULY AUTHORIZED

                                By /s/ James F. Winschel, Jr.
                                  -----------------------------------------
                                Name James F. Winschel, Jr.
                                    ---------------------------------------
                                Title Senior VP and Chief Financial Officer
                                     --------------------------------------
                                     HEREUNTO DULY AUTHORIZED

                                      -5-<PAGE>   1
                                                                     EXHIBIT 4.1

Number

                                                             COMMON STOCK
                                                             $0.01 PAR VALUE
                                                             PER SHARE
                                                             SHARES

KPMG CONSULTING

              INCORPORATED UNDER THE LAWS OF THE STATE OF DELAWARE

                                                             Cusip No. 48265R109
KPMG CONSULTING, INC.                                        SEE REVERSE FOR
                                                             CERTAIN DEFINITIONS

THIS CERTIFIES THAT

IS THE OWNER OF

FULLY PAID AND NON-ASSESSABLE SHARES OF COMMON STOCK, $0.01 PAR VALUE PER SHARE
                            OF KPMG CONSULTING, INC.

transferable in person or by duly authorized attorney on the books of the
Corporation upon surrender of this certificate properly endorsed.
     This certificate and the shares represented hereby are issued and shall be
held subject to the laws of the State of Delaware and the provisions of the
Certificate of Incorporation and the By-laws of the Corporation, as amended
from time to time, to which the holder by acceptance hereof assents.
     This certificate is not valid until countersigned and registered by the
Transfer Agent and Registrar.
     IN WITNESS WHEREOF the Corporation has caused this certificate to be
signed by the facsimile signatures of its duly authorized officers and a
facsimile of its corporate seal hereunto affixed.

Dated:                                     /s/ Randolph C. Blazer

                                           PRESIDENT AND CHIEF EXECUTIVE OFFICER

Countersigned and Registered:
  EQUISERVE TRUST COMPANY, N.A.
      Transfer Agent and Registrar          /s/ David W. Black

                                           EXECUTIVE VICE PRESIDENT,
By  /s/                                    SECRETARY AND GENERAL COUNSEL
               Authorized Signature

                [KPMG CONSULTING, INC. CORPORATE SEAL DELAWARE]
<PAGE>   2

                             KPMG CONSULTING, INC.

<TABLE>
<S><C>
         The following abbreviations, when used in the Inscription on the face of this Certificate, shall be
construed as though they were written out in full according to applicable laws or regulations:

TEN COM - as tenants in common                            UNIF GIFT MIN ACT - ________  Custodian ___________
                                                                                (Cust)              (Minor)
TEN ENT - as tenants by the entireties                                        under Uniform Gifts to Minors

JT TEN  - as joint tenants with right                                         Act ___________________________
          of survivorship and not as                                                      (State)
          tenants in common
                                                          UNIF TRAN MIN ACT - _________ Custodian ______________
                                                                               (Cust)               (Minor)

                                                                              under Uniform Transfers to Minors

                                                                              Act _______________________________
                                                                                          (State)

                      Additional abbreviations may also be used though not in the above list.

              For value received, ___________________________________ hereby sell, assign and transfer unto

PLEASE INSERT SOCIAL SECURITY OR OTHER
   IDENTIFYING NUMBER OF ASSIGNEE
 ______________________________________
|                                      |
|______________________________________|___________________________________________________________________________

___________________________________________________________________________________________________________________
                   PLEASE PRINT OR TYPEWRITE NAME AND ADDRESS INCLUDING POSTAL ZIP CODE OF ASSIGNEE

___________________________________________________________________________________________________________________

___________________________________________________________________________________________________________________

___________________________________________________________________________________________________________ Shares

of the capital stock represented by the within Certificate, and do hereby irrevocably constitute and appoint ______

___________________________________________________________________________________________________________________

___________________________________________________________________________________________________________________

Attorney to transfer the said stock on the books of the within-named Corporation with full power of substitution in
the premises.

Dated, _______________________________________________

                                                               X _________________________________________________
                                                                 NOTICE: THE SIGNATURE(S) TO THIS ASSIGNMENT MUST
                                                                 CORRESPOND WITH THE NAME AS WRITTEN UPON THE FACE
                                                                 OF THE CERTIFICATE, IN EVERY PARTICULAR, WITHOUT
                                                                 ALTERATION OR ENLARGEMENT, OR ANY CHANGE WHATEVER.

                                                                 THE SIGNATURE(S) SHOULD BE GUARANTEED BY AN ELIGIBLE
                                                                 GUARANTOR INSTITUTION (BANKS, STOCKBROKERS, SAVINGS
                                                                 AND LOAN ASSOCIATIONS AND CREDIT UNIONS WITH
                                                                 MEMBERSHIP IN AN APPROVED SIGNATURE GUARANTEE
                                                                 MEDALLION PROGRAM), PURSUANT TO S.E.C. RULE 17Ad-18

                                                                 SIGNATURE(S) GUARANTEED:

KEEP THIS CERTIFICATE IN A SAFE PLACE, IF LOST, STOLEN, MUTILATED OR DESTROYED, THE CORPORATION WILL REQUIRE A BOND
OF INDEMNITY AS A CONDITION TO THE ISSUANCE OF A REPLACEMENT CERTIFICATE.

</TABLE>

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