Document:

Exhibit 4.3
                                                                     -----------

                                SANOFI-SYNTHELABO

                 General Meeting of Shareholders of May 18, 1999

                       Translation of Resolution number 29

RESOLUTION 29 (Authorization that need to be given to the Company for granting
options to subscribe and to buy shares)

The General Meeting of shareholders, regularly convened in conformity with the
quorum and majority requirements applicable to extraordinary shareholder
meetings, after examination of the report from the Board of Directors and the
special report from the auditors ("Commissaires aux comptes"), and provided that
the shares of the Company be admitted for trading on the First Market with
Monthly Regulations ("Premier Marche a Reglement Mensuel"):

     -    authorizes the Board of Directors, within the framework of the
          legislation on commercial corporations, to grant options to subscribe
          in newly issued shares of the Company that will be issued as a capital
          increase or options to buy existing shares that have been redeemed by
          the Company within the limits set by the law, for the benefit of
          wage-earning employees and corporate officers ("mandataires sociaux")
          of the Company and of French or foreign corporations or groups of
          corporations that are connected to the Company following the
          conditions set forth in article 208-4 of the law of July 24, 1966 on
          commercial corporations (loi du 24 juillet 1966 sur les societes
          commerciales), as those members will be defined by the Board;

     -    decides that the total number of options that would be granted by
          virtue of the present authorization cannot lead to the subscription or
          purchase of a number of shares that exceeds 2% of the company's share
          capital or 3.652.935 shares; provided that if the 39th and 40th
          Resolutions set forth hereafter were adopted by the General Meeting,
          the number of shares would be 14.611.740;

     -    makes present authorization valid for a period of five years from the
          date of present General Meeting;

     -    decides that, in compliance with the law, the issue price or the
          purchase price of the shares cannot be less than 80% of the average of
          the stock quotations on this market during the past 20 trading
          sessions preceding the day of the meeting of the Board of Directors at
          which the options will be granted, it being understood that,
          furthermore, regarding the options to buy stock, the purchase price of
          the stock on the day the option will be granted cannot be less than
          80% of the average purchase price paid by the Company for the stock it
          holds in compliance with the law, at the date on which the options
          will be granted;

     -    decides that the options need to be exercised in a period no longer
          than 10 years from the day they will be granted;

     -    records that the present authorization holds, for the benefit of the
          grantees of subscription options, that the shareholders expressly
          waive their preferential subscription rights for the shares that will
          be issued progressively upon exercise of the options and decides that
          the amount in capital increase as a result should be added to the
          amount of capital increase authorized by the present General Meeting
          according to the 24th, 25th, 27th and 28th Resolutions.

The Board of Directors is given full powers, in the limits described above, to:

     -    set the conditions for the granting of the options, the dividend
          entitlement of the shares ("les modalites de jouissance") and, if
          needed, for the release of the shares (paid-up shares), said
          conditions can contain clauses that restrict immediate resale of all
          or part of the shares, provided however that the minimum holding
          period cannot exceed three years from the exercise of the option, and
          to add or modify the conditions relating to these options if
          necessary;

     -    make up the list of beneficiaries (i.e. grantees) of the options, as
          prescribed above;

     -    decide at which conditions the price and number of shares can be
          adjusted, in particular in the different hypothesis set forth in
          articles 174-8 to 174-16 of Decree number 67-236 of March 23, 1997;

     -    set the period or periods for exercising the options that will be
          granted;

     -    foresee the possibility to temporarily suspend the right to exercise
          the options for a period of maximum three months in case of financial
          operations that imply the exercise of a right attached to the shares;

     -    accomplish or have accomplished all acts and formalities in order to
          render definitive all capital increases that can be done in accordance
          with the authorization given under the present Resolution; adapt the
          articles in consequence, and more generally, do all that will be
          necessary;

     -    by its own decision and if it considers it opportune, impute the costs
          of capital increases on the amount of premiums related to such capital
          increases and to deduct from that amount the sums necessary to make
          sure the legal reserve ("la reserve legale"), after each capital
          increase, reaches the level of 10% of the new capital amount.

The General Meeting records the fact that the capital increase resulting from
the exercise of the options will be definitely accomplished by the sole
subscription of the new shares accompanied by the declaration (notice) of the
exercise of the options and the liberation of the paid-in capital for the
shares, which can be accomplished either in cash or by compensation with
monetary claims against the Company.

At the first meeting after the closing of each exercise, the Board of Directors,
or on delegation, the President, will establish, if it is necessary, the number
and the amount of shares issued, during the period set for exercise of the
options, as a result of the exercise of options and will change the articles
accordingly to reflect that change.

This Resolution has been adopted unanimously.Exhibit 4.4
                                                                    ------------

                                                                        MAY 2001

                 STOCK OPTION PURCHASE PLAN OF SANOFI-SYNTHELABO

                             RULES OF THE 1 ST PLAN
       VOIDS THE FORMER VERSION MAILED TO THE BENEFICIARIES IN JUNE, 2000

                                   **********

                            1. Participants

                            2. Duration of the Plan

                            3. Stock Option Exercise

                            4. SALE OF SHARES

                            5. SHARE RIGHTS

                            6. OPTION PRICE ADJUSTMENT

                       Free Translation of French version
                                    May 2001

<PAGE>

The Board of Directors of SANOFI-SYNTHELABO was authorized by a General Meeting
of its Shareholders held on May 18th 1999, according to Articles L.225-177 to
L.225-185 of the French Commercial Code to set up a stock option purchase plan
for the whole of the SANOFI-SYNTHELABO group. By SANOFI-SYNTHELABO group we mean
all companies or groupings of economic interest defined by Article L.225-180 of
the aforementioned code.

Following the proposal of its Chairman, the Board of Directors had laid down the
rules of the stock option purchase plan with effect from May 24, 2000.

At the time, there was some uncertainty on the tax and labour regime applicable
to this plan due to a reform on the tax regime applicable to stock-options
pending in Parliament. For this reason, the Board of Directors had decided on
May 24, 2000, that it might change these rules at a future meeting in order to
adapt them if necessary to the provisions which would be enacted.

As the law was voted by Parliament on May 2, 2001, the Board finally amended the
said rules at his meeting of May 10, 2001. This text annuls and voids the
version adopted by the Board at its meeting of May 24, 2000.

1.    PARTICIPANTS

      Upon the recommendation of the Chairman of SANOFI-SYNTHELABO acting upon
      the advice of the Remuneration Comittee, the grant of options to purchase
      shares of SANOFI-SYNTHELABO to a list of identified employees and the
      number of options granted to each such employee is approved by the Board
      of Directors.

      The rights granted are not transferable unless the options are exercised.

2.    DURATION OF THE PLAN

      SANOFI-SYNTHELABO's Stock Option Plan number 1 has a duration of ten years
      from the date of the approval of the Board of Directors on May 24, 2000.
      It will expire on May 24, 2010.

3.    STOCK OPTION EXERCISE

      The exercise of the options, also called "exercise of the options to
      acquire shares" is not allowed during the first four years following the
      Board of Directors' approval on May 24, 2000.

      The options can be exercised at any time between May 25, 2004 and May 24,
      2010 inclusive. (To sell the shares see Item 4 below).

      Option rights cannot be exercised in case of resignation, unless otherwise
      decided by the General Management of the Company in exceptional cases.
      Revocation of option rights takes effect on the day of notice of
      resignation.

      Options rights cannot be exercised either in case of dismissal for serious
      reasons. Revocation of option rights takes effect on the day of notice of
      dismissal.

      The Company reserves the right to temporarily suspend the exercise of the
      options, in particular when there are certain changes in the capital
      structure of SANOFI-SYNTHELABO.

      Exceptions :

      3.1    If an employee retires or takes early retirement during the option
             period, at normal retirement age or earlier with the agreement of
             the Company, the participant keeps his/her option rights until
             their expiration, that is May 24, 2010.

      3.2    Notwithstanding the four-year period mentioned under Article 3,
             Paragraph 1, if an employee becomes disabled during the option
             period, and such disability meets the conditions of the second and
             third categories as defined by Article L.341-1 of the French Social
             Security Code, the participant may exercise his options. The
             participant keeps his/her option rights until their expiration,
             that is May 24, 2010.

      3.3    Notwithstanding the four-year period mentioned under Article 3,
             Paragraph 1, if an employee dies during the option period, his/her
             heirs can exercise the options during the six month period
             following the date of death.

4.    SALE OF SHARES

      The sale of the shares through the exercise of the options is possible
      from May 25, 2004 on.

      However, any participant mentioned under article 3.2 or the heirs of a
      participant who has died mentioned under article 3.3 above are able to
      sell the corresponding shares without waiting for the end of the four year
      holding period.

     For purely information purposes(1), participants who are tax resident in
     France are advised that on the basis of tax rules that will apply to the
     current option plan, the tax charge on the benefit arising from the
     exercise of the option and which is equal to the difference between the
     stock exchange price on the day of the exercise of the option and the
     exercise price, may vary according to the following two factors:

     -    whether or not the shares arising from the exercise of the option have
          been kept for at least two years after May 24, 2004

     -    whether the benefit exceeds, or is less than, 1 million French Francs

     The attached schedule summarises the tax structure. This will be explained
     in greater detail in an information note to be sent to participants by the
     bank.

1 Each participant should seek advice on the tax regime governing the exercise
of options or the sale of the shares which is applicable to him.

5.    SHARE RIGHTS

      Shares acquired as a result of the exercise of the stock-options will be
      entitled to the same rights and will be treated in the same manner as the
      Company's ordinary shares. Holders of stock-options who exercise such
      options between January 1 and the date upon which the dividend is declared
      for the prior fiscal year will be entitled to receive the dividend paid on
      the shares in respect of the prior fiscal year.

6.       OPTION PRICE ADJUSTMENT

      In the case of a new issuance of securities to be subscribed only by
      existing shareholders, or in the case of any other capital transaction
      which effects the situation of existing shareholders, the exercise price
      and the number of shares to which an option gives right will be adjusted
      in order to take into account such issuance or other capital transaction.

      If such a situation is covered by existing law or regulation, such law or
      regulation shall be applied.

      If such a situation is not covered by existing law or regulation (i.e., an
      issuance of securities without preferential subscription rights other than
      convertible or exchangeable bonds, a reduction of capital for reasons
      other than to cover losses), the General Meeting of Shareholders or the
      Board of Directors when deciding to conduct such securities issuance or
      other capital transaction will adopt any measures necessary to protect the
      rights of the holders of the stock-options, using by analogy the rules and
      regulations which would govern similar cases.

                                   **********

<PAGE>

<TABLE>
<CAPTION>

                                                                                                     SCHEDULE

-------------------------------------------------------------------------------------------------------------------------
<S>                                     <C>                                      <C>
                                        Sale (or conversion to bearer form) Sale
                                        (or conversion to bearer form) after May
                                        24, 2004 if shares held less after May
                                        24, 2004 if shares held more than 2
                                        years thereafter than 2 years thereafter
-------------------------------------------------------------------------------------------------------------------------
Benefit arising from the exercise of
the option less than or equal to 1      Subject to income tax as capital gain    Subject to income tax as capital gain
million F                               on securities (1) at rate of 30%(2)      on securities (1) at rate of 16% (2)
-------------------------------------------------------------------------------------------------------------------------
Benefit arising from the exercise       Subject to income tax as capital         Subject to income tax as capital
the option exceeding 1 million F        gain on securities (1) at rate of        gain on securities (1) at rate of

                                           -     30%(2) for the amount up to 1      -     16%(2) for the amount up to 1
                                                 million F per year                       million F per year

                                           -     40%(2) for the rest                -     30%(2) for the rest
-------------------------------------------------------------------------------------------------------------------------
Capital                                 gain on sale Subject to income tax as capital gain on securities at rate
                                        of 16% (2) (except where the annual amount of sales of securities is below
                                        the exempt ceiling)
-------------------------------------------------------------------------------------------------------------------------
</TABLE>

(1) Except if one opts for the regime governing wages.

(2) One should add to these rates social contributions ("CSG" + "CRDS" + social
deduction of 2%). The effective tax rates corresponding to the rates of 16%, 30%
and 40%, become respectively 26%, 40% and 50%.

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00054-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00054-of-00352.parquet"}]]