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Prepared by MERRILL CORPORATION

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AMENDMENT TO EMPLOYMENT AGREEMENT    
  

W. SCOTT HARKONEN ("EXECUTIVE"):

    Effective
March 6, 2001, INTERMUNE PHARMACEUTICALS, INC. (the "Company") has amended, as follows, that certain Employment
Agreement between Executive and the Company, which became effective as of October 15, 1998, as amended on June 8, 2000 (the "Agreement"): 

	1.
	Section 2.1—First Sentence: In lieu of "Two Hundred Seventy-Five Thousand Dollars ($275,000.00)," the
"annual base salary" shall be "Three Hundred Thousand Dollars ($300,000), effective as of January 1, 2001. Any upward adjustments to Executive's annual base salary may be effected by the
approval of the Company's Compensation Committee, with ratification by the Company's Board of Directors, without necessity of amending this Agreement."

	2.
	Section 2.1—Add the following sentence to the end of the section: 

"Executive
shall be paid a bonus of his Base Compensation, based upon achievement of the Company's prior calendar year's corporate milestones." 

	3.
	Section 4—Delete the last sentence that reads: 

"Notwithstanding
the foregoing, the Company agrees that Executive may devote an average of 20% of each work week to furnish consulting services to Connetics Corporation; provided, that Executive's
Base Compensation shall be reduced by 20% during such period as he performs such consulting services." 

	4.
	Section 8.3—In the first sentence, in lieu of the "Chief Executive Officer," the signatories shall be "Executive"
and "Senior Vice President of Legal Affairs."

	5.
	Section 8.10—Add the following Section 8.10: 

"This
Agreement, as amended on March 6, 2001, and that certain Common Stock Purchase Agreement, dated as of April 27, as amended February 23, 2000 (the "Stock Purchase
Agreement"), constitute the entire agreement between the parties with respect to the subject matter hereof and supersede and merge all prior agreements or understandings, whether written or oral. With
respect to interpretation and construction of provisions that may be inconsistent between this Agreement and the Stock Purchase Agreement, the provisions of the Stock Purchase Agreement shall
control." 

	6.
	Except
as specifically amended and modified herein, the Agreement shall continue in force and effect pursuant to its terms. 

Dated
the 6th day of March 2001. 

	 
	 	 
	 	 

	 	 	INTERMUNE PHARMACEUTICALS, INC.
	

 	
 	

 	
 	

 
	 	 	By:	 	/s/ STEPHEN N. ROSENFIELD   
STEPHEN N. ROSENFIELD

Senior Vice President of Legal Affairs

1

 
 
 

ACKNOWLEDGEMENT    
  

    The undersigned acknowledges receipt of the foregoing amendment and understands that the rights and liabilities with respect to the Employment Agreement
described therein are set forth in the Employment Agreement. 

Dated
the 6th day of March 2001. 

	 
	 	 
	 	 

	 	 	 	 	/s/ W. SCOTT HARKONEN   
W. SCOTT HARKONEN

2

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AMENDMENT TO EMPLOYMENT AGREEMENT

ACKNOWLEDGEMENTPrepared by MERRILL CORPORATION

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Exhibit 10.38    
  

    
January 25, 2001 

Ms. Anna
Hall

Director of Business Development

Genentech, Inc.

1 DNA Way

South San Francisco

CA 94080-4990 

RE:    AMENDMENT NO. 5 TO THE INTERMUNE/GENENTECH LICENSE AGREEMENT

Dear
Ms. Hall: 

    Please
consider this document as Amendment No. 5 to that certain License Agreement for Interferon Gamma, dated May 5, 1998; as amended on December 26, 1998;
January 15, 1999; April 27, 1999; and June 23, 2000 (collectively, the "Agreement"), between INTERMUNE PHARMACEUTICALS, INC. and  GENENTECH,
 INC. (collectively, the "Parties"). 

    1.  The Parties agree that the first sentence of Section 2.2(b) of the Agreement is hereby terminated in its
entirety and amended and superseded as follows: 

	"(b)
	Use
of the Mark. In using the Actimmune mark, InterMune shall display said mark with either the first letter in uppercase (i.e., Actimmune) or all letters in uppercase (i.e.,
ACTIMMUNE)." 

    2.  All other sections and exhibits of the Agreement remain unchanged. 

    3.  This Amendment No. 5 to the Agreement is made effective as of January 25, 2001. 

    IN WITNESS THEREOF, the parties have executed this Amendment No. 5 to the Agreement as of the date set forth below. 

	INTERMUNE PHARMACEUTICALS, INC.	 	GENENTECH, INC.
	

By	
 	

/s/ JOHN J. WULF   
 John Wulf

Sr. Vice President of Corporate Development	
 	

By	
 	

/s/ JOSEPH S. MCCRACKEN   

	

 	
 	

 	
 	

Print Name	
 	

Joseph S. McCracken

	

 	
 	

 	
 	

Title	
 	

VP BUSINESS DEVELOPMENT

	

Date	
 	

January 25, 2001
	
 	

Date	
 	

4/5/01

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Exhibit 10.38<PAGE>

                                                                    Exhibit 10.1

                             FIFTH AMENDMENT TO THE
                             INVITROGEN CORPORATION
                             1997 STOCK OPTION PLAN

         Pursuant to Section 12 of the Invitrogen Corporation 1997 Stock Option
Plan, as amended (the "Plan"), the Plan is hereby amended to add a new Section
4.3 thereto to read as follows:

                  "4.3 INDIVIDUAL SHARE LIMIT. The maximum aggregate number of
         shares of Stock with respect to which Options may be granted during any
         calendar year to any Employee may not exceed 500,000 shares or, in the
         case of the calendar year during which an Employee first commences
         employment with any Participating Company, 1,000,000 shares (subject to
         adjustment to reflect changes in capital structure covered by Section
         4.2 above)."<PAGE>

                                                                  Exhibit 10.2

                                CONTRACT OF SALE

         THIS CONTRACT OF SALE ("THIS CONTRACT") is made and entered into as of
March 7, 2001 (the "CONTRACT DATE") by and between INVITROGEN CORPORATION, a
Delaware corporation ("SELLER"), and HUMAN GENOME SCIENCES, INC., a Delaware
corporation ("BUYER").

         1. SALE. Seller agrees to sell and convey to Buyer, and Buyer agrees to
purchase from Seller, for the purchase price set forth below and on the terms
and conditions set forth in this Contract, all of the following:

                  1.1 those certain tracts or parcels of land, together with all
rights, easements, and interests appurtenant thereto including, but not limited
to, any streets or other public ways adjacent to such tracts or parcels and any
water or mineral rights owned by, or leased to, Seller, which are described on
EXHIBIT A attached hereto and made a part hereof (collectively, the "LAND");

                  1.2 all of the buildings, structures, fixtures, and other
improvements located on the Land, including, but not limited to, the buildings
commonly known by the street address 9800 Medical Center Drive, Rockville,
Maryland 20849 (collectively, the "BUILDINGS"), and all other on-site
structures, systems, and utilities associated with the Buildings (the Buildings
and all such improvements being collectively referred to herein as the
"IMPROVEMENTS");

                  1.3 all of Seller's right, title, and interest in and to the
existing laboratory infrastructure (e.g., specialized water systems, casework,
heating, ventilation, and air conditioning systems and equipment, autoclave,
fermenters, glass wash equipment, walk-in refrigeration units, chemical fume
hoods, centralized vacuum, gas, and spare parts related thereto) owned by Seller
and used by Seller in connection with the ownership and operation of the Land
and the Improvements, as specifically listed on EXHIBIT I attached hereto
(collectively, the "PERSONAL PROPERTY"). From the Contract Date to Thursday,
March 22, 2001 (the "DOCUMENT FINALIZATION PERIOD"), Seller and Buyer shall use
their reasonable and good faith efforts to finalize the list of Personal
Property set forth in EXHIBIT I attached hereto as a part hereof. On the
finalization of such list, the final list shall be substituted in place of the
list attached hereto as a part hereof as EXHIBIT I and the parties shall
identify the final list by initialing it. EXHIBIT L attached hereto as a part
hereof identifies the matters that Seller and Buyer are to resolve during the
Document Finalization Period.

                  1.4 all of Seller's right, title, and interest in and all
assignable contracts and agreements to which Seller is party that are listed and
described on EXHIBIT B attached hereto and made a part hereof (subject to
amendment pursuant to this Section) relating to the upkeep, repair, maintenance,
or operation of the Land, Improvements, or Personal Property and all comparable
contracts, agreements, or arrangements into which Seller enters before Closing
pursuant to this Contract (collectively, the "CONTRACTS"). During the Document
Finalization Period, Seller and Buyer shall use their reasonable and good faith
efforts to finalize the list of Contracts set forth in EXHIBIT B attached hereto
as a part hereof. On the finalization of such list,

<PAGE>

the final list shall be substituted in place of the list attached hereto as a
part hereof as EXHIBIT B and the parties shall identify the final list by
initialing it; and

                  1.5 to the extent transferable, all of Seller's right, title,
and interest (if any) in and to the following: (a) systems and building manuals
relating to the Improvements to the extent in Seller's actual possession, (b)
all guaranties and warranties issued with respect to the Personal Property, the
Buildings, or the Improvements; (c) all "as built" plans and specifications,
drawings, and prints describing the Buildings and/or the Improvements to the
extent in Seller's actual possession; (d) trademarks or trade names associated
with the Buildings and/or Improvements, EXCLUDING, HOWEVER, the name "Life
Technologies, Inc.," or "LTI," or any derivation of such names; (e) all
licenses, permits, approvals, certificates of occupancy, dedications, and
entitlements now or hereafter issued, approved, or granted by any governmental
authority in connection with the Land or the Improvements, including the right
to increase the floor area ratio density on the Land up to 313,650 square feet
(collectively, the "INTANGIBLES").

The Land, the Improvements, and the Personal Property, Contracts, and
Intangibles associated therewith are hereinafter sometimes referred to as the
"PROPERTY."

         2. PURCHASE PRICE. The total purchase price to be paid to Seller by
Buyer for the Property shall be an amount equal to Fifty-Five Million Dollars
($55,000,000) (the "PURCHASE PRICE"). During the Document Finalization Period,
Seller and Buyer shall use their reasonable efforts to agree on the allocation
of the Purchase Price between the Personal Property, on the one hand, and the
Land, Improvements, Contracts, and Intangibles, on the other hand. Such agreed
allocation shall be reflected by an amendment to this Contract executed and
delivered by Seller and Buyer.

         3. CLOSING. The purchase and sale contemplated herein shall be
consummated at a closing ("CLOSING") to take place by mail or at the offices of
the Title Company (as defined below). The Closing shall occur on or before
Monday, April 30, 2001 (the "CLOSING DATE"); PROVIDED, HOWEVER, that if Buyer's
performance of a Phase II Study (as defined below) is not completed by April 30,
2001, Closing shall occur (unless Buyer terminates this Contract as provided in
Section 5 below) within ten (10) days after Buyer's timely completion of the
Phase II Study as provided in Section 5.2 below. Buyer shall use commercially
reasonable efforts to close before April 30, 2001.

         4. DEPOSIT. Contemporaneous with Buyer's execution and delivery of this
Contract, Buyer shall deposit, as its earnest money deposit, the sum of Five
Million Dollars ($5,000,000) (the "EARNEST MONEY") by means of a Federal Reserve
wire transfer of immediately available funds in a strict joint order, interest
bearing escrow with the Title Company (the "ESCROW"). The Earnest Money and all
interest earned thereon are herein collectively referred to as the "DEPOSIT."
Except as otherwise expressly set forth herein, the Deposit shall be
non-refundable but shall be applied against the Purchase Price at Closing.

                                       2
<PAGE>

         5. ENVIRONMENTAL INSPECTION PERIOD.

                  5.1 PHASE I STUDY. From the Contract Date to March 2, 2001
(the "ENVIRONMENTAL INSPECTION PERIOD"), Buyer and its employees, agents, and
third party consultants (collectively, the "BUYER'S REPRESENTATIVES") shall be
entitled to enter on the Land and Improvements, at reasonable times and on
reasonable notice to Seller, to perform a phase I environmental study of the
Land (the "PHASE I STUDY"). Buyer shall provide not less than twenty-four (24)
hours' prior telephonic notice to Seller before performing any such study.

                  5.2 PHASE II STUDY. If the Phase I Study discloses a
"recognized environmental condition" (as that phrase is defined in ASTM E1527-00
Standard Practice for Environmental Site Assessments: Phase 1 Environmental Site
Assessment Process; the "ASTM STANDARDS"), then Buyer at its sole election may
extend the Environmental Inspection Period for a period not to exceed sixty (60)
days to enable Buyer to perform a Phase II environmental study within the
meaning of the ASTM Standards (the "PHASE II STUDY"; the Phase I Study and the
Phase II Study, if any, are hereinafter collectively referred to as the
"ENVIRONMENTAL STUDIES"). Buyer shall make such election by notifying Seller and
Escrow Agent in writing before the expiration of the Environmental Inspection
Period. Buyer shall perform the Environmental Studies as soon as possible using
commercially reasonable efforts. If the Environmental Studies reveal
environmental conditions that are unacceptable to Buyer in the exercise of its
commercially reasonable judgment, Buyer may terminate this Contract before the
last day of the Environmental Inspection Period (as it may have been extended as
provided in this Section 5.2) (the "APPROVAL DATE") by notifying Seller and
Escrow Agent in writing (the "TERMINATION NOTICE"). On receipt of the
Termination Notice, Buyer shall as a condition to the return of the Deposit,
deliver to Seller true, correct, and complete copies of the Environmental
Studies. On receipt of the Termination Notice by Seller and Escrow Agent, Escrow
Agent shall return the Deposit to Buyer and neither party shall have any further
liabilities or obligations except for those liabilities and obligations that
expressly survive a termination of this Contract. If Buyer fails timely to
deliver a Termination Notice to Seller and the Escrow Agent before the end of
the Environmental Inspection Period (as extended, if applicable), Buyer shall be
automatically deemed to have forever waived its right to terminate this Contract
and receive a refund of the Deposit (except as otherwise expressly provided
herein) and the Property shall be deemed acceptable to Buyer.

                  5.3 BUYER'S UNDERTAKING. Buyer hereby covenants and agrees
that it shall cause the Environmental Studies to be performed in a manner that
does not unreasonably disturb or disrupt the business operations of Seller. If
Buyer performs a Phase II Study (which may include physically intrusive
investigations of the Land and Improvements, such as sampling of soils and other
media), Buyer shall provide a written scope of work to Seller describing in
reasonable detail the procedures Buyer desires to perform and request Seller's
express written consent to the Phase II Study, which consent shall not be
unreasonably withheld, delayed, or conditioned. Buyer and Buyer's
Representatives shall, in performing the Environmental Studies, comply with the
agreed on procedures and with any and all Laws (as defined below) applicable to
such procedures or to the Land and Improvements, or both. Neither Buyer nor
Buyer's Representatives shall report the results of the Environmental Studies to
any Governmental Authority (as defined below) under any circumstances without
first obtaining Seller's express

                                       3
<PAGE>

written consent, which consent may be withheld in Seller's sole and absolute
subjective discretion; PROVIDED, HOWEVER, that if the results of the
Environmental Studies are required to be reported by any Law, Seller shall
promptly report such results to the extent so required. If Seller fails to do
so, Buyer may report such results to the appropriate Governmental Authority
if such failure to report would expose Buyer to legal liability. For purposes
of this Contract, "LAW" means all applicable laws, ordinances, rules, and
regulations, codes, licenses, permits, orders, approvals, plans,
authorizations, and similar items of any applicable federal, state,
municipal, or other governmental or quasi-governmental department,
commission, board, bureau, agency, or instrumentality (collectively, the
"GOVERNMENTAL AUTHORITY").

                  5.4 REPORTS; INSURANCE; RESTORATION. Buyer shall promptly
provide Seller with copies of any Environmental Studies promptly after Buyer's
receipt thereof. Buyer and Buyer's Representatives shall: (a) maintain
commercial general liability (occurrence) insurance in an amount of not less
than Two Million Dollars ($2,000,000) covering any accident arising in
connection with the presence of Buyer and Buyer's Representatives at the Land
and the Improvements and the performance of any Environmental Studies, and
deliver to Seller before Buyer's entry on the Land or the Improvements a
certificate of insurance (on ACORD Form 27, if available) that names Seller as
an additional insured thereunder verifying such coverage; (b) promptly pay when
due any third party costs resulting from the Environmental Studies; (c) promptly
pay when due any third party costs resulting from the access provided to the
Land and the Improvements hereunder to the extent such costs would give rise to
Buyer's obligation to indemnify Seller under Section 5.5 (Indemnification)
below; and (d) restore the Land and Improvements to substantially the same
condition in which the same were found before any such entry on the Land and the
Improvements and inspection or examination was undertaken and repair any damage
to the Land or the Improvements to the extent such condition was altered or the
Land or Improvements were damaged in connection with the Environmental Studies.

                  5.5 INDEMNIFICATION. Buyer hereby indemnifies, protects,
defends (with counsel reasonably acceptable to Seller), and holds Seller,
Seller's affiliates, their respective shareholders, officers, and directors, and
all of their respective successors and assigns (collectively, the "SELLER
INDEMNIFIED PARTIES"), harmless from and against any and all losses, damages,
claims, causes of action, judgments, damages, costs, and expenses (including,
but not limited to, court costs and reasonable attorneys' fees) (collectively,
"LOSSES") to the extent that any Seller Indemnified Party suffers or incurs as a
result of, or in connection with, (a) any damage caused to, in, or at the
Property; (b) injury or death to person; or (c) mechanic's liens or
materialmen's liens arising out of, or in connection with, the Environmental
Studies, or Buyer's or Buyer's Representatives entry on the Land and the
Improvements hereunder; PROVIDED, HOWEVER, that Buyer shall not be obligated to
indemnify and hold Seller Indemnified Parties harmless from Losses to the extent
that the Losses (i) result from Seller's sole negligence or intentional
misconduct, or (ii) involve damage to the Property and Closing occurs under this
Contract. Buyer's undertakings pursuant to this Section 5 shall survive Closing
for a period that shall end on the sixtieth (60th) day after the third (3rd)
anniversary of the Closing Date, unless a specific claim in writing with respect
to such matters shall have been made by Seller prior thereto. Seller shall
promptly notify Buyer of any claim relating to any such Losses.

                                       4
<PAGE>

                  5.6 PROPRIETARY INFORMATION. Buyer acknowledges that Seller's
business operations involve the use of highly sensitive, confidential, and
proprietary information (the "PROPRIETARY INFORMATION"), and that it is
imperative that Buyer and Buyer's Representatives be accompanied by an
authorized agent of Seller during any entry into the Buildings by Buyer and
Buyer's Representatives. Because of the sensitive nature of Seller's business
operations, it may not be possible to provide ready access to Buyer and Buyer's
Representatives to every part of the Buildings at any given time. For purposes
of this Contract, Proprietary Information includes (a) all information or
material of Seller that is proprietary because it has a significant business
purpose and is unique to the business and operations of Seller, including, but
not limited to, methods, strategies, software, technology, computer programs,
customer and prospect lists, supplier lists, records, product design or
development, financial information, budgets, marketing plans, pricing
information and strategies, cost data, salary information, market information,
personnel, trade secrets, and other business information; (b) inventions,
discoveries, concepts, technical information, processes, formulas,
specifications and know-how conceived, obtained, or developed in whole or in
part by Seller or its employees or agents, or created, in whole or in part, with
Seller's equipment, supplies, personal property, or facilities; and (c)
information and materials received by Seller from third parties in confidence
(i.e., subject to non-disclosure or similar covenants).

                  5.7 CONFIDENTIALITY. Each party agrees to maintain in
confidence the information contained in this Contract or pertaining to the sale
contemplated hereby, including, but not limited to, the Proprietary Information
(the "TRANSACTION INFORMATION"). Buyer shall maintain in strict confidence the
Environmental Studies. Each party shall not under any circumstances disclose all
or any portion of the Transaction Information (and Buyer shall not disclose the
Environmental Studies) to any person or entity and shall maintain the
Transaction Information (and Buyer shall maintain the Environmental Studies) in
the strictest confidence as confidential information; PROVIDED, HOWEVER, that
either party may disclose the Transaction Information (and Buyer may disclose
the Environmental Studies) (a) to such party's agents, employees, attorneys,
lenders, underwriters, consultants, and accountants to the extent that such
parties reasonably need to know such information and data to assist, and perform
services on behalf of, Buyer or Seller, as the case may be; (b) to the extent
required by any applicable Law (except as provided in Section 5.3 above); and
(c) in connection with any litigation that may arise between the parties in
connection with the transactions contemplated by this Contract. Buyer shall
advise Buyer's Representatives of the provisions of this Section 5.7 and cause
such parties to maintain the Transaction Information and the Environmental
Studies as confidential information and to comply with the terms of this Section
5.7. Buyer agrees that the Environmental Studies and any Proprietary Information
obtained in conducting the Environmental Studies shall be used solely for
purposes of evaluating the acquisition of the Property from Seller.
Notwithstanding anything contained herein to the contrary, it is understood and
agreed that money damages would not be a sufficient remedy for any breach of
this Section 5.7 by Buyer or Buyer's Representatives and that Seller shall be
entitled to specific performance and injunctive or other equitable relief as a
remedy for any such breach of this Section 5.7 by Buyer or Buyer's
Representatives, and Buyer further agrees to waive any requirement for the
security or posting of any bond in connection with such remedy. Such remedy
shall not be deemed to be the exclusive remedy for a breach of this Section 5.7
but shall be in addition to all other remedies available at law or equity to
Seller. Buyer hereby

                                       5
<PAGE>

indemnifies, protects, defends, and holds Seller Indemnified Parties harmless
from and against any and all Losses to the extent suffered or incurred by any
Seller Indemnified Parties as a result of, or in connection with, (A) any
disclosure of the Transaction Information or the Environmental Studies by
Buyer or Buyer's Representatives other than in accordance with this Section
5.7, or (B) any other breach of this Section 5.7 by Buyer or Buyer's
Representatives. The undertakings of Buyer pursuant to this Section 5.7 (y)
with respect to the Proprietary Information shall indefinitely survive the
Closing or termination of this Contract and shall not be merged into any
instrument of conveyance delivered at Closing, and (z) with respect to
Transaction Information other than the Proprietary Information, shall
terminate at Closing and shall be merged into any instrument of conveyance
delivered at Closing. Before Closing, Seller and Buyer shall obtain the prior
written approval of the other (which approval shall not be unreasonably
withheld, delayed, or conditioned) before making any public announcements
concerning the transactions contemplated by this Contract.

         6. TITLE MATTERS.

                  6.1 CONVEYANCE OF TITLE. At Closing, Seller agrees to deliver
to Buyer a special warranty deed ("DEED") for the Property, in the form attached
hereto as a part hereof as EXHIBIT C, conveying the Property to Buyer, free and
clear of all liens, claims, and encumbrances except for the following items (the
"PERMITTED EXCEPTIONS"): (a) taxes not yet due and payable; (b) all matters
appearing of record relating to the Property as of the date of the Title
Commitment, including the matters appearing on the Title Commitment; (c) matters
arising out of any act of Buyer or Buyer's Representatives; and (d) Laws,
including, but not limited to, zoning ordinances.

                  6.2 TITLE COMMITMENT. Contemporaneous with the execution of
this Contract, Buyer shall deliver to Seller a commitment (the "TITLE
COMMITMENT"), dated as of January 21, 2001 issued by Presidential Title, Inc.
(the "TITLE COMPANY"), for an owner's title insurance policy (the "TITLE
POLICY") insured by Commonwealth Land Title Insurance Company ("Title Insurer"),
in the full amount of the Purchase Price, showing fee simple title to the Land
in Seller and that title to the Property is good of record and in fact,
marketable, and insurable at regular rates by the Title Insurer, together with
copies of all recorded documents evidencing title exceptions raised in "Schedule
B" of the Title Commitment. Buyer shall pay the cost of the title insurance
premiums along with any and all other costs related to the Title Commitment and
the Title Policy, including, but not limited to, the cost of "extended form
coverage," any endorsements and all search, continuation and later-date fees.

                  6.3 MANDATORY CURE ITEMS. Seller shall be obligated to cure
and remove by Closing all of the following class of matters affecting title to
the Property that are disclosed in the Title Commitment, if any: (a) the liens
of any mortgage, trust deed, or deed of trust encumbering the Property
evidencing an indebtedness owed by Seller; (b) tax liens for delinquent ad
valorem real estate taxes, judgment liens, and other tax liens; (c) broker's
liens pursuant to a written agreement between the broker and any Seller Parties;
(d) mechanic's liens pursuant to a written agreement either between (i) the
claimant (the "CONTRACT CLAIMANT") and Seller or its employees, officers, or
managing agents (the "SELLER PARTIES") or (ii) the Contract Claimant and any
other contractor, materialman, or supplier with which Seller or Seller Parties

                                       6
<PAGE>

have a written agreement; and (e) other matters affecting title to the Project
created by Seller on or after the date of the Title Commitment without Buyer's
prior written consent.

                  6.4 CERTIFICATE OF CONVEYANCE AND CONFIRMATORY DEED. Buyer
acknowledges (a) that Seller has filed a certificate of conveyance with the
Maryland State Department of Assessments and Taxation and is in the process of
recording among the Land Records of Montgomery County, Maryland a confirmatory
deed from Life Technologies, Inc. ("LTI") to Seller reflecting the merger of LTI
into Seller and Seller shall use its reasonable efforts to complete such
recordation before Closing, and (b) receipt of the form of certificate of
conveyance and confirmatory deed.

         7. SELLER'S REPRESENTATIONS AND WARRANTIES.

                  7.1 SELLER'S REPRESENTATIONS. Seller represents and warrants
to Buyer that the following matters (collectively, the "SELLER REPRESENTATIONS")
are true as of the Contract Date in all material respects except as may
otherwise be provided in the Documents. Seller shall reaffirm the Seller
Representations at Closing by means of a certification in the form of EXHIBIT J
attached hereto as a part hereof.

                           7.1.1 LITIGATION. There is no pending or, to
Seller's Knowledge (as defined below), threatened litigation or governmental
proceedings against Seller or the Property that, if such litigation or
proceedings were to result in a final determination against Seller or the
Property, would result in material encumbrance on the Property, or would
materially affect the validity or enforceability of this Contract or the
performance of Seller under this Contract.

                           7.1.2 UNITED STATES PERSON. Seller is a "United
States Person" within the meaning of Section 1445(f)(3) of the Internal Revenue
Code of 1986, as amended, and shall execute and deliver an "Entity Transferor"
certification at Closing in the form of EXHIBIT D attached hereto as a part
hereof.

                           7.1.3 CONDEMNATION. There is no pending or, to
Seller's Knowledge, contemplated condemnation or other governmental taking
proceedings affecting all or any part of the Land and the Improvements.

                           7.1.4 DUE AUTHORIZATION. Seller is a corporation duly
organized, validly existing, and in good standing under Delaware law, and is
qualified to do business in and is in good standing under Maryland law. Seller
has full power to execute, deliver, and carry out the terms and provisions of
this Contract and each of the other agreements, instruments, and documents
herein required to be made or delivered by Seller pursuant hereto, and has
taken, or will take before Closing, all necessary action to authorize the
execution, delivery, and performance of this Contract and such other agreements,
instruments, and documents. The individuals executing this Contract and all
other agreements, instruments, and documents herein required to be made or
delivered by Seller pursuant hereto on behalf of Seller are and shall be duly
authorized to sign the same on Seller's behalf and to bind Seller thereto.

                                       7
<PAGE>

                           7.1.5 ENFORCEABILITY; CONFLICT. This Contract has
been, and each and all of the other agreements, instruments, and documents
herein required to be made by Seller pursuant hereto have been, or on the
Closing Date will have been, executed by or on behalf of Seller, and when so
executed, are and shall be legal, valid, and binding obligations of Seller
enforceable against Seller in accordance with their respective terms, subject to
applicable bankruptcy, insolvency, reorganization, moratorium, and other similar
laws affecting the rights of creditors generally and, as to enforceability, the
general principles of equity (regardless of whether enforcement is sought in a
proceeding in equity or at law). The execution and delivery of, and consummation
of the transactions contemplated by, this Contract is not prohibited by, and
will not conflict with, constitute grounds for termination of, or result in the
breach of any of the agreements or instruments to which Seller is now party or
by which it is bound, or to Seller's Knowledge, any order, rules, or regulation
of any court or other Governmental Authority.

                           7.1.6 CONTRACTS. To Seller's Knowledge and subject to
the provisions of Section 1.4, Seller is not party to any service contracts,
management contracts, or other comparable agreements that are binding on the
Land and the Improvements other than the Contracts.

                           7.1.7 BANKRUPTCY MATTERS. Seller has not made a
general assignment for the benefit of creditors, filed any voluntary petition in
bankruptcy or suffered the filing of an involuntary petition by its creditors,
suffered the appointment of a receiver to take possession of substantially all
of its assets, suffered the attachment or other judicial seizure of
substantially all of its assets, admitted its inability to pay its debts as they
come due, or made an offer of settlement, extension, or composition to its
creditors generally.

                           7.1.8 ENVIRONMENTAL MATTERS. To Seller's Knowledge
and except as disclosed on EXHIBIT H attached hereto, Seller has received no
written notification from any Governmental Authority properly addressed to
Seller that (a) all or some portion of the Property violates any Environmental
Laws (as defined below); or (b) any Hazardous Substances (as defined below) have
been stored or generated at, released, or discharged from or are present on the
Property, except in the ordinary course of Seller's business and in accordance
in all material respects with all Environmental Laws. In response to a written
request from ManTech Environmental Corporation ("MANTECH"), Buyer's
environmental consultant, Seller provided to ManTech documentation requested by
ManTech relating to environmental matters relating to the Property. To Seller's
Knowledge, the documentation so provided to ManTech was accurate and complete in
all material respects and Seller did not intentionally withhold any information
from the documentation so provided to ManTech. As used in this Contract,
(i) "HAZARDOUS SUBSTANCES" means all hazardous or toxic materials, substances,
pollutants, contaminants, petroleum products or wastes currently identified as a
hazardous substance or waste in the Comprehensive Environmental Response,
Compensation and Liability Act of 1980 (commonly known as "CERCLA"), as amended,
the Superfund Amendments and Reauthorization Act (commonly known as "SARA"), the
Resource Conservation and Recovery Act (commonly known as "RCRA"), or any other
Law applicable to the Property, and (ii) the term "ENVIRONMENTAL LAWS" shall
mean all Laws enacted or issued by any Governmental Authority and in effect as
of the Contract Date with respect to or which otherwise pertain to or affect the
Land or the Improvements, or any portion thereof, the use, ownership, occupancy,
or operation

                                       8
<PAGE>

of the Land or the Improvements, or any portion thereof, or any owner of the
Land, and as the same have been amended, modified, or supplemented from time
to time before the date of this Contract, including but not limited to
CERCLA, SARA, RCRA, the Hazardous Substances Transportation Act (49 U.S.C.
Section 1802 et seq.), the Water Pollution Control Act (33 U.S.C. Section 1251
et seq.), the Safe Drinking Water Act (42 U.S.C. Section 300f et seq.),
the Clean Air Act (42 U.S.C. Section 7401 et seq.), the Solid Waste Disposal
Act (42 U.S.C. Section 6901 et seq.), the Toxic Substances Control Act
(15 U.S.C. Section 2601 et seq.), the Emergency Planning and Community
Right-to-Know Act of 1986 (42 U.S.C. Section 11001 et seq.), comparable
state and local laws, and any rules and regulations that have become effective
before the date of this Contract under any of the laws specified above.

                  7.2 SELLER'S KNOWLEDGE. All references in this Contract to
"SELLER'S KNOWLEDGE," "SELLER'S ACTUAL KNOWLEDGE," or words of similar import
shall refer only to the actual (as opposed to deemed, imputed, or constructive)
present knowledge of (a) Delano W. Tucker, Sr., without inquiry (with respect to
those provisions in Section 7.1 modified to Seller's Knowledge with the
exception of Section 7.1.1 (Litigation)), and (b) John A. Cottingham, without
inquiry (with respect solely to the provisions of Section 7.1.1 (Litigation)).
Notwithstanding any fact or circumstance to the contrary, Seller's Knowledge
shall not be construed to refer to the knowledge of any other person or entity.
Seller represents and warrants that Mr. Tucker has been the Facilities Manager
of the Property since its construction and that Mr. Cottingham is the general
counsel of Seller. Messrs. Tucker and Cottingham shall have no personal
liability whatsoever under this Contract.

                  7.3 LIMITATIONS. Seller Representations shall survive the
Closing Date, the delivery of the Deed, and transfer of title to the Property
until March 31, 2002. No claim for a breach of any Seller Representation, or the
failure or default of a covenant or agreement of Seller, shall be actionable or
payable unless (a) the breach in question results from or is based on a
condition, state of facts, or other matter that was not disclosed to or known by
Buyer to its actual (as opposed to deemed, imputed, or constructive) knowledge
before Closing, (b) the valid claims for all such breaches collectively
aggregate more than One Hundred Thousand Dollars ($100,000), in which event the
full amount of such claims shall be actionable, and (c) written notice
containing a description of the specific nature of such breach shall have been
given by Buyer to Seller before March 31, 2002 and an action shall have been
commenced by Buyer against Seller within one (1) year after Closing.
Notwithstanding anything contained in this Contract to the contrary:

                           7.3.1 Buyer shall not be entitled to any
consequential, speculative, or punitive damages in connection with any suits,
litigation, or administrative proceedings resulting from any breaches by Seller
of Seller Representations or covenants of Seller.

                           7.3.2 If Buyer is notified in writing by Seller or
otherwise becomes aware (which awareness shall be deemed to the extent Buyer is
provided with access to books, records, files, or other material that
contradicts a Seller Representation) that any Seller Representation made by
Seller is not true or correct as of the Contract Date, or that such Seller
Representation is not true or correct on or before the Closing, or is notified
in writing by Seller or otherwise becomes aware (which awareness shall be deemed
to the extent Buyer is provided with access to books, records, files, or other
material that indicates a covenant of Seller has not been satisfied) that Seller
has failed

                                       9
<PAGE>

to perform any covenant and agreement herein contained and Buyer shall
nevertheless acquire the Property notwithstanding such fact, Buyer shall not
be entitled to commence any action after Closing to recover damages from
Seller due to such Seller Representation failing to be true or correct (and
Buyer shall not be entitled to rely on such Seller Representation), or such
covenant and agreement having failed to be performed by Seller.

                           7.3.3 In case of Seller's breach of the Seller
Representation contained in Section 7.1.6 (Contracts) that involves Seller's
failure to disclose a Contract that is not terminable on no more than thirty
(30) days' notice without penalty, Seller shall indemnify, protect, and defend
and hold Buyer harmless from and against all losses, claims, costs, expenses,
and damages (including, but not limited to, reasonable attorneys' fees) incurred
by Buyer in terminating such undisclosed Contract. The provisions of this
Section 7.3.3 shall survive the Closing and shall not be merged into any
instrument of conveyance delivered at Closing. Buyer, however, acknowledges and
agrees that the (a) Contract involving the food service operation in the Commons
Building (the "FOOD SERVICE CONTRACT") expires in November 2002 and that the
Food Service Contract requires a four (4) month termination notice, and (b)
Contract involving elevator maintenance for the elevators in the Buildings
expires on or about January 31, 2002 and cannot be terminated before that date.

                  7.4 MODIFICATIONS. Between the Contract Date and the Closing
Date, Seller shall notify Buyer in writing of any event or condition that, to
Seller's Knowledge, will cause a material change in the facts relating to, or
the truth of, any of the Seller Representations. Seller shall be entitled to
modify the Seller Representations to reflect changes thereto from the Contract
Date to the Closing Date (a) that arise in the ordinary course of Seller's
operation of the Property, (b) that are not caused by the negligence or
intentional misconduct of Seller or its agents, employees, or contractors, and
(c) as long as such modifications shall not materially adversely affect the use
or value of the Property.

         8. BUYER'S COVENANTS AND REPRESENTATIONS. Effective as of the Contract
Date, Buyer hereby covenants with Seller as follows:

                  8.1 DUE AUTHORIZATION. Buyer is a Delaware corporation duly
organized, validly existing, and in good standing under Delaware law and is
qualified to do business in and is in good standing under Maryland law. Buyer
has full power to execute, deliver, and carry out the terms and provisions of
this Contract and each of the other agreements, instruments, and documents
herein required to be made or delivered by Buyer pursuant hereto, and has taken
all necessary action to authorize the execution, delivery, and performance of
this Contract and such other agreements, instruments, and documents. The
individuals executing this Contract and all other agreements, instruments, and
documents herein required to be made or delivered by Buyer pursuant hereto on
behalf of Buyer are and shall be duly authorized to sign the same on Buyer's
behalf and to bind Buyer thereto.

                  8.2 ENFORCEABILITY. This Contract has been, and each and all
of the other agreements, instruments, and documents herein required to be made
by Buyer pursuant hereto have been, or on the Closing Date will have been,
executed by Buyer or on behalf of Buyer, and when so executed, are and shall be
legal, valid, and binding obligations of Buyer enforceable

                                       10
<PAGE>

against Buyer in accordance with their respective terms, subject to
applicable bankruptcy, insolvency, reorganization, moratorium, and other
similar laws affecting the rights of creditors generally and, as to
enforceability, the general principles of equity (regardless of whether
enforcement is sought in a proceeding in equity or at law).

                  8.3 NO CONFLICT. The execution and delivery of, and
consummation of the transactions contemplated by this Contract is not prohibited
by, and will not conflict with, constitute grounds for termination of, or result
in the breach of any of the agreements or instruments to which Buyer is now
party or by which it is bound, or any order, rule or regulation of any court or
other Governmental Authority.

Buyer shall reaffirm the foregoing representations and warranties at Closing by
means of a certification in the form of EXHIBIT K attached hereto as a part
hereof.

         9. ACTIONS AFTER THE CONTRACT DATE. The parties covenant to do the
following through the Closing Date:

                  9.1 TITLE. From and after the Contract Date, Seller shall not
make any change to the condition of title to the Land and the Improvements that
would change the condition of title approved or deemed approved by Buyer
pursuant to Section 6, except as required by Law or Section 6 or with Buyer's
advance written consent, which consent shall not be unreasonably withheld,
delayed, or conditioned. From and after the Approval Date, Seller shall not
sell, or assign or create any right, title, or interest in, the Land, or any
part thereof, or create any lien, encumbrance, or charge thereon, without the
prior written consent of Buyer, which consent shall not be unreasonably
withheld, delayed, or conditioned.

                  9.2 MAINTENANCE AND OPERATION OF PROPERTY. Seller shall
maintain the Property in substantially its current condition (normal wear and
tear and damage by casualty excepted); shall maintain existing insurance
coverage in full force and effect; and shall operate and maintain the Property
in the ordinary course of Seller's business; PROVIDED, HOWEVER, that in no event
shall Seller be obligated to make any capital repairs, replacements, or
improvements to the Improvements. Seller shall have the right to enter into any
new contract with respect to the ownership and operation of the Property that
will survive the Closing, or that would otherwise affect the use, operation, or
enjoyment of the Property after Closing, as long as the new contract is
terminable on no more than thirty (30) days' prior written notice without
penalty or termination fee to Buyer (any such new contract shall be deemed a
"Contract" for purposes of this Contract).

                  9.3 WARN ACT. Seller shall comply with the requirements of the
Worker Adjustment and Retraining Notification Act ("WARN ACT") to the extent the
WARN Act affects the transactions contemplated by this Contract. Seller shall
indemnify, protect and defend and hold Buyer harmless from and against all
losses, claims, costs, expenses and damages (including, but not limited to,
reasonable attorneys' fees) resulting from Seller's failure to comply with the
WARN Act as provided in this Section 9.3. The provisions of this Section 9.3
shall survive the Closing for a period that shall end on the sixtieth (60th) day
after the third (3rd) anniversary of the Closing Date and shall not be merged
into any instrument of conveyance delivered at Closing.

                                       11
<PAGE>

         10. PROPERTY SOLD "AS IS".

                  10.1 GENERAL. Except as is otherwise expressly provided in
this Contract, Seller hereby specifically disclaims any warranty (oral or
written) concerning (a) the nature and condition of the Property and the
suitability thereof for any and all activities and uses that Buyer may elect to
conduct thereon; (b) the manner, construction, condition, and state of repair or
lack of repair of the Improvements; (c) the nature and extent of any
right-of-way, lien, encumbrance, license, reservation, condition, or otherwise;
(d) the compliance of the Property or its operation with any Laws, it being
specifically understood that Buyer shall have full opportunity, during the
Environmental Inspection Period, to determine for itself the environmental
condition of the Property; (e) the accuracy or completeness of any statements,
calculations, or conditions stated or set forth in Seller's books and records
concerning the Property or set forth in any of Seller's offering materials for
the Property; and (f) any other matter whatsoever except as expressly set forth
in this Contract. Except as is otherwise expressly provided in this Contract,
the sale of the Property as provided for herein is made on a strictly "AS IS"
"WHERE IS" "WITH ALL FAULTS" basis as of the Closing Date. EXCEPT AS OTHERWISE
EXPRESSLY PROVIDED IN THIS CONTRACT, BUYER EXPRESSLY ACKNOWLEDGES THAT, IN
CONSIDERATION OF THE AGREEMENTS OF SELLER IN THIS CONTRACT, SELLER MAKES NO
WARRANTY OR REPRESENTATION, EXPRESS OR IMPLIED, OR ARISING BY OPERATION OF LAW,
INCLUDING, BUT IN NO WAY LIMITED TO, ANY WARRANTY OF QUANTITY, QUALITY,
CONDITION, HABITABILITY, MERCHANTABILITY, SUITABILITY OR FITNESS FOR A
PARTICULAR PURPOSE OF THE PROPERTY, ANY IMPROVEMENTS LOCATED THEREON, OR ANY
SOIL CONDITIONS RELATED THERETO.

                  10.2 NO RELIANCE. BUYER SPECIFICALLY ACKNOWLEDGES THAT IT IS
NOT RELYING ON (AND SELLER HEREBY DISCLAIMS AND RENOUNCES) ANY REPRESENTATIONS
OR WARRANTIES MADE BY OR ON BEHALF OF SELLER OF ANY KIND OR NATURE WHATSOEVER,
EXCEPT AS IS OTHERWISE EXPRESSLY PROVIDED IN THIS CONTRACT. EXCEPT AS OTHERWISE
EXPRESSLY PROVIDED IN THIS CONTRACT, BUYER, FOR BUYER AND BUYER'S SUCCESSORS AND
ASSIGNS, HEREBY RELEASES SELLER FROM AND WAIVES ANY AND ALL CLAIMS AND
LIABILITIES AGAINST SELLER FOR, RELATED TO, OR IN CONNECTION WITH, ANY
ENVIRONMENTAL CONDITION AT THE PROPERTY (OR THE PRESENCE OF ANY MATTER OR
SUBSTANCE RELATING TO THE ENVIRONMENTAL CONDITION OF THE PROPERTY), INCLUDING,
BUT NOT LIMITED TO, CLAIMS AND/OR LIABILITIES RELATING TO (IN ANY MANNER
WHATSOEVER) ANY HAZARDOUS, TOXIC OR DANGEROUS MATERIALS OR SUBSTANCES LOCATED
IN, AT, ABOUT, OR UNDER THE PROPERTY, OR FOR ANY AND ALL CLAIMS OR CAUSES OF
ACTION (ACTUAL OR THREATENED) BASED ON, IN CONNECTION WITH, OR ARISING OUT OF
ENVIRONMENTAL LAW OR ANY OTHER CLAIM OR CAUSE OF ACTION (INCLUDING ANY FEDERAL
OR STATE BASED STATUTORY, REGULATORY, OR COMMON LAW CAUSE OF ACTION) RELATED TO
ENVIRONMENTAL MATTERS OR LIABILITY WITH RESPECT TO OR AFFECTING THE PROPERTY.
BUYER REPRESENTS TO SELLER THAT BUYER HAS CONDUCTED, OR

                                       12
<PAGE>

WILL CONDUCT BEFORE CLOSING, SUCH INVESTIGATIONS OF THE PROPERTY WITH
QUALIFIED PROFESSIONALS OF ITS OWN SELECTION, INCLUDING BUT NOT LIMITED TO,
THE PHYSICAL AND ENVIRONMENTAL CONDITIONS THEREOF, AS BUYER DEEMS NECESSARY
TO SATISFY ITSELF AS TO THE CONDITION OF THE PROPERTY AND THE EXISTENCE OR
NONEXISTENCE OR CURATIVE ACTION TO BE TAKEN WITH RESPECT TO ANY HAZARDOUS
SUBSTANCES ON OR DISCHARGED OR RELEASED FROM THE PROPERTY AND WILL RELY
SOLELY ON SAME AND NOT ON ANY INFORMATION PROVIDED BY OR ON BEHALF OF SELLER
OR ITS AGENTS OR EMPLOYEES WITH RESPECT THERETO, OTHER THAN SUCH
REPRESENTATIONS, WARRANTIES, AND COVENANTS OF SELLER AS ARE EXPRESSLY SET
FORTH IN THIS CONTRACT. UPON CLOSING, EXCEPT AS OTHERWISE EXPRESSLY PROVIDED
IN THIS CONTRACT, BUYER SHALL ASSUME THE RISK THAT ADVERSE MATTERS,
INCLUDING, BUT NOT LIMITED TO, CONSTRUCTION DEFECTS AND ADVERSE PHYSICAL AND
ENVIRONMENTAL CONDITIONS, MAY NOT HAVE BEEN REVEALED BY BUYER'S
INVESTIGATIONS, AND BUYER, ON CLOSING, SHALL BE DEEMED TO HAVE WAIVED,
RELINQUISHED, AND RELEASED SELLER FROM AND AGAINST ANY AND ALL CLAIMS,
DEMANDS, CAUSES OF ACTION (INCLUDING CAUSES OF ACTION IN TORT), LOSSES,
DAMAGES, LIABILITIES, COSTS AND EXPENSES (INCLUDING ATTORNEYS' FEES AND COURT
COSTS) OF ANY AND EVERY KIND OR CHARACTER, KNOWN OR UNKNOWN, WHICH BUYER
MIGHT HAVE ASSERTED OR ALLEGED AGAINST SELLER, AT ANY TIME BY REASON OF OR
ARISING OUT OF ANY LATENT OR PATENT CONSTRUCTION DEFECTS OR PHYSICAL
CONDITIONS, VIOLATIONS OF ANY APPLICABLE LAWS (INCLUDING, WITHOUT LIMITATION,
ANY ENVIRONMENTAL LAWS) AND ANY AND ALL OTHER ACTS, OMISSIONS, EVENTS,
CIRCUMSTANCES, OR MATTERS REGARDING THE PROPERTY. EXCEPT AS OTHERWISE
EXPRESSLY PROVIDED IN THIS CONTRACT, BUYER AGREES THAT SHOULD ANY CLEANUP,
REMEDIATION, OR REMOVAL OF HAZARDOUS SUBSTANCES OR OTHER ENVIRONMENTAL
CONDITIONS ON THE PROPERTY BE REQUIRED AFTER THE CLOSING DATE, SUCH CLEANUP,
REMOVAL, OR REMEDIATION SHALL BE THE RESPONSIBILITY OF AND SHALL BE PERFORMED
AT THE SOLE COST AND EXPENSE OF BUYER.

                  10.3 INDUCEMENT. BUYER ACKNOWLEDGES AND AGREES THAT THE
PROVISIONS CONTAINED IN THIS SECTION 10 WERE A MATERIAL FACTOR IN SELLER'S
ACCEPTANCE OF THE PURCHASE PRICE AND THAT SELLER WAS UNWILLING TO SELL THE
PROPERTY TO BUYER UNLESS SELLER WAS RELEASED AS EXPRESSLY SET FORTH ABOVE.
BUYER, WITH BUYER'S COUNSEL, HAS FULLY REVIEWED THE DISCLAIMERS AND WAIVERS SET
FORTH IN THIS CONTRACT, AND UNDERSTANDS THE SIGNIFICANCE AND EFFECT THEREOF.
BUYER ACKNOWLEDGES AND AGREES THAT THE DISCLAIMERS AND OTHER AGREEMENTS SET
FORTH IN THIS CONTRACT ARE AN INTEGRAL PART OF THIS CONTRACT, AND THAT SELLER
WOULD NOT HAVE AGREED TO SELL THE PROPERTY TO BUYER FOR THE PURCHASE PRICE
WITHOUT THE DISCLAIMER AND OTHER AGREEMENTS SET FORTH IN THIS CONTRACT. THE
TERMS AND CONDITIONS OF THIS SECTION 10 WILL EXPRESSLY SURVIVE THE CLOSING AND

                                       13
<PAGE>

WILL NOT MERGE WITH THE PROVISIONS OF ANY CLOSING DOCUMENTS, INCLUDING, BUT NOT
LIMITED TO, THE DEED.

         11. SELLER'S CLOSING DELIVERIES. At Closing (or such other times as may
be specified below), Seller shall deliver or cause to be delivered to Buyer the
following:

                  11.1 DEED. A Deed, executed by Seller, for the Property
conveying the Land and Improvements to Buyer, subject to the Permitted
Exceptions. Seller, however, shall have no obligation to execute and deliver to
Buyer, the Title Company, or any other entity or person an affidavit of title,
owner's affidavit, or similar instrument.

                  11.2 LEASE. Two (2) duly executed counterparts of a lease
agreement ("LEASE") between Buyer, as landlord, and Seller, as tenant,
substantially in the form attached hereto as EXHIBIT G. During the Document
Finalization Period, Seller and Buyer shall use their reasonable and good faith
efforts to finalize the terms and conditions of the Lease, it being acknowledged
and agreed that certain terms and conditions of the Lease remain subject to
negotiation. On the finalization of the terms and conditions of the Lease, such
final form shall be substituted in place of the form of Lease attached hereto as
a part hereof as EXHIBIT G and the parties shall identify the final form of
Lease by initialing it. If Seller and Buyer are unable to agree, despite the
exercise of their reasonable and good faith efforts, on the final terms and
conditions of the Lease by the end of the Document Finalization Period, the
Escrow Agent shall return the Deposit to Buyer, this Contract shall terminate,
and neither Seller nor Buyer shall have any further liabilities or obligations
except for those liabilities and obligations that expressly survive a
termination of this Contract. For purposes of this Contract, the Lease may
ultimately be in the form of a sublease between Seller, as subtenant, and Buyer,
as sublandlord, and, if so, (a) Buyer shall obtain the prior written consent of
the fee owner of the Property to the sublease, and (b) Seller and Buyer shall
modify the Lease so that it is in the form of a sublease.

                  11.3 ASSIGNMENT OF CONTRACTS. Two (2) duly executed
counterparts of an Assignment and Assumption of Contracts and Intangibles (an
"ASSIGNMENT OF CONTRACTS") for the Property in the form attached hereto as
EXHIBIT E. The effective date of the Assignment of Contracts shall be Monday,
October 1, 2001. Between the Closing Date and September 30, 2001, Seller shall
have the right to enter into any new contract with respect to the ownership and
operation of the Property that will have an expiration date after September 30,
2001, or that would otherwise affect the use, operation, or enjoyment of the
Property after September 30, 2001, as long as the new contract is terminable on
no more than thirty (30) days' prior written notice without penalty or
termination fee to Buyer (any such new contract shall be deemed a "Contract" for
purposes of this Contract). Buyer shall have the right to approve any such new
contract, which approval shall not be unreasonably withheld, delayed, or
conditioned. If Buyer does not approve or disapprove such new contract within
five (5) Business Days after written request to do so, Buyer shall be deemed to
have approved such new contract. If Seller enters into a new contract that is
not terminable on no more than thirty (30) days' prior written notice or
contains a penalty or termination fee, or both, and Buyer does not timely object
to such new contract, Seller shall indemnify, protect, and defend and hold Buyer
harmless from and against all losses, claims, costs, expenses, and damages
(including, but not limited to, reasonable attorneys' fees) incurred by Buyer in
connection with such undisclosed new contract. The

                                       14

<PAGE>

provisions of this Section 11.3 shall survive the Closing and shall not be
merged into any instrument of conveyance delivered at Closing.

                  11.4 BILL OF SALE. Two (2) duly executed counterparts of a
Bill of Sale (the "BILL OF SALE") for the Property in the form attached hereto
as EXHIBIT F.

                  11.5 CLOSING STATEMENT. Two (2) duly executed counterparts of
a closing statement (the "CLOSING STATEMENT") conforming to the proration and
other relevant provisions of this Contract, which Closing Statement shall be in
a form mutually and reasonably agreed to by Seller and Buyer.

                  11.6 FIRPTA CERTIFICATE. Entity Transfer Certification in the
form of EXHIBIT D attached hereto as a part hereof.

                  11.7 REAFFIRMATION OF SELLER REPRESENTATIONS. A Reaffirmation
of Seller Representations in the form of EXHIBIT J attached hereto as a part
hereof.

                  11.8 OTHER DOCUMENTS. Such other documents as may be
reasonably agreed on between Buyer and Seller for purposes of consummating the
transactions contemplated by this Contract.

         12. BUYER'S CLOSING DELIVERIES. At Closing (or at such other times as
may be specified below), Buyer shall deliver or cause to be delivered to Seller
the following:

                  12.1 CLOSING STATEMENT. Two (2) Closing Statements executed in
counterpart by Buyer.

                  12.2 LEASE. Two (2) Leases executed in counterpart by Buyer.

                  12.3 ASSIGNMENT OF CONTRACTS. Two (2) Assignment of Contracts
executed in counterpart by Buyer.

                  12.4 BILL OF SALE. Two (2) Bill of Sales executed in
counterpart by Buyer.

                  12.5 REAFFIRMATION OF BUYER REPRESENTATIONS. A Reaffirmation
of Buyer Representations in the form of EXHIBIT K attached hereto as a part
hereof.

                  12.6 CORPORATE RESOLUTIONS. Corporate resolutions of Buyer
authorizing Buyer to enter into this Contract and perform its obligations
hereunder. Such resolutions shall contain, among other things, a statement
indicating that Buyer has ascribed a value of at least Nine Million Dollars
($9,000,000) to the Administration Building.

                  12.7 OTHER DOCUMENTS. Such other documents as may be
reasonably agreed on between Buyer and Seller for purposes of consummating the
transactions contemplated by this Contract.

                                       15
<PAGE>

         13. PAYMENT OF PURCHASE PRICE; PRORATIONS AND ADJUSTMENTS. Provided all
conditions precedent to Seller's obligations hereunder have been satisfied,
Seller shall convey title to the Property to Buyer on confirmation of receipt of
the Purchase Price by the Escrow Agent as set forth below. Buyer shall pay the
balance of the Purchase Price, as adjusted by the prorations and expenses to be
paid by Seller hereunder, to Escrow Agent by making a wire transfer of
immediately available federal funds to the account of Escrow Agent no later than
11:00 a.m. Eastern Time on the Closing Date and unconditionally directing Escrow
Agent to deposit the same (and Escrow Agent shall in fact initiate the transfer
by such time) in Seller's designated account by 2:00 p.m. Eastern Time on the
Closing Date. For each full or partial day after the Closing Date that Escrow
Agent has not received in its account the payment specified in this Contract,
Buyer shall pay to Seller one (1) day's interest on the unpaid funds at the rate
PER ANNUM equal to the "prime rate" as announced from time to time by THE WALL
STREET JOURNAL. The following items shall be prorated and adjusted between
Seller and Buyer:

                  13.1 UTILITIES. Water, electricity, sewer, natural gas,
telephone, and other utility charges based, to the extent practicable, on final
meter readings and final invoices. Such expenses shall be prorated between Buyer
and Seller, with Seller receiving a credit for any expenses paid by Seller and
related to the period from and after Closing.

                  13.2 EXISTING CONTRACTS. Amounts paid or payable under the
Contracts shall be prorated.

                  13.3 ASSESSMENTS. All assessments, general or special, shall
be prorated as of the Closing Date, with Seller being responsible for any
installments of assessments that are due before the Closing Date and Buyer being
responsible for any installments of assessments that are due on or after the
Closing Date.

                  13.4 TAXES. All ad valorem real estate and personal property
taxes for the Property shall be prorated as of the Closing Date on a cash basis
for the tax year in which the Closing occurs, regardless of the year for which
such taxes are assessed. Buyer shall pay all sales tax payable in connection
with the Personal Property, which sales tax shall be collected by Seller and
thereafter paid over to the State of Maryland within the time required by law.

                  13.5 OTHER. Such other items that are customarily prorated in
transactions of this nature shall be ratably prorated.

                  13.6 ADJUSTMENTS. If any prorations made pursuant hereto shall
prove incorrect for any reason, or if the prorations set forth above are
estimated on the most currently available (rather than based on the actual
final) bills, either party shall be entitled to an adjustment to correct the
same provided that it makes written demand on the other by no later than the
first anniversary of the Closing Date. The provisions of this Section 13 shall
survive Closing.

         14. CLOSING EXPENSES. Seller shall only pay for: one-half (1/2) of any
applicable recordation and transfer taxes and one-half (1/2) of the cost of any
escrows hereunder. Buyer shall pay for one-half (1/2) of any escrow costs
hereunder, one-half (1/2) of any applicable recordation and transfer tax, the
cost of recording the Deed, the basic premium for the Title

                                       16
<PAGE>

Policy, the cost of "extended form coverage" and any endorsements to the
Title Policy, the cost of any survey, and any recordation tax on the
recordation of any instrument evidencing or securing any financing obtained
by Buyer for all or any portion of the Property. Each party shall pay the
costs of its respective consultants, attorneys, accountants, and other
professionals.

         15. DESTRUCTION, LOSS OR DIMINUTION OF PROPERTY. If, before Closing,
all or any portion of the Property is damaged by fire or other natural casualty
(collectively "DAMAGE"), or is taken or made subject to condemnation, eminent
domain, or other governmental acquisition proceedings (collectively "EMINENT
DOMAIN"), then:

                  15.1 GENERAL. If the aggregate cost of repair or replacement
or the value of the Eminent Domain (collectively, "REPAIR AND/OR REPLACEMENT")
is Three Million Dollars ($3,000,000) or less, in the opinion of Buyer's and
Seller's respective engineering consultants, Buyer shall close and take the
Property as diminished by such events with an assignment by Seller of any
casualty insurance proceeds (together with a credit from Seller to Buyer of the
full amount of any deductible not paid directly by Seller) or condemnation
proceeds and the payment by Seller to Buyer of any applicable deductible
amounts, less any amounts reasonably incurred by Seller to repair the Property
and collect the insurance proceeds or condemnation award.

                  15.2 MATERIAL DAMAGE. If the aggregate cost of repair and/or
replacement is greater than Three Million Dollars ($3,000,000), in the opinion
of Buyer's and Seller's respective engineering consultants, then Buyer, at its
sole option, may elect either to (a) terminate this Contract by written notice
to Seller and the Escrow Agent, in which event the Deposit shall be returned to
Buyer and neither party shall have any further liability to the other hereunder,
except for those liabilities that expressly survive a termination of this
Contract; or (b) proceed to close and take the Property as diminished by such
events, together with an assignment of the proceeds of Seller's casualty
insurance (together with a credit from Seller to Buyer of the full amount of any
deductible not paid directly by Seller) for all Damage (or condemnation awards
for any Eminent Domain) and the payment by Seller to Buyer of any applicable
deductible amounts, less any amounts reasonably incurred by Seller to repair the
Property and collect the insurance proceeds or condemnation award.

                  15.3 DISPUTES. If a dispute arises between Seller and Buyer
with respect to the cost of repair and/or replacement for the matters set forth
in this Section, an engineer designated by Seller and an engineer designated by
Buyer shall select an independent engineer licensed to practice in Maryland who
shall resolve such dispute. All fees, costs, and expenses of such third engineer
so selected shall be shared equally by Buyer and Seller.

         16. DEFAULT.

                  16.1 DEFAULT BY SELLER. In addition to the provisions of
Section 18 (Litigation), if Seller shall be in material default hereunder any of
the covenants and agreements of Seller hereunder, or in the event of a material
breach by Seller of any Seller Representation when made that is not cured by
Seller (in Seller's sole and absolute subjective discretion) on or before
Closing, Buyer may either (a) terminate Buyer's obligations under this Contract
by written notice to Seller and the Escrow Agent, in which event (i) the Deposit
shall be returned to Buyer, and

                                       17
<PAGE>

(ii) on Buyer's receipt of the Deposit, this Contract shall terminate and
neither party shall have any further liability hereunder except for those
liabilities that expressly survive a termination of this Contract; or (b)
Buyer may file an action for specific performance, provided that no such
action in specific performance shall seek to require Seller to do any of the
following: (i) change the condition of the Property or restore the same after
any fire or other casualty; (ii) expend money or post a bond to remove a
title encumbrance or defect or correct any matter shown on a Survey of the
Property that Seller has not agreed to remove or correct pursuant to the
provisions of this Contract; (iii) secure any permit, approval, or consent
for the Property or Seller's conveyance of the Property where the failure to
secure any such permit, approval, or consent would not constitute a breach of
any representation or warranty of Seller under the provisions of this
Contract; or (iv) vacate the Property in advance of the applicable expiration
date for the space in question under the Lease. If Buyer prevails on the suit
for specific enforcement in a court of competent jurisdiction, the Lease
shall be of no force or effect and Seller shall have no right to lease the
Property on the terms and conditions set forth in the Lease. Buyer shall have
no other remedy for any default by Seller. In the event of the failure of any
condition precedent to Buyer's obligation to close expressly herein set
forth, Buyer's sole remedy hereunder, at law or in equity, shall be to
terminate this Contract, in which event the Escrow Agent shall return the
Deposit to Buyer, whereupon neither party shall have any further liability
hereunder except for those liabilities that expressly survive a termination
of this Contract. If, as a direct result of an intentional act of Seller
taken with the intention of frustrating Closing or the willful misconduct of
Seller, Seller is in breach or default of its obligations hereunder, and
Buyer elects to terminate this Contract under clause (a) above on account of
such breach or default, then, on such termination by Buyer hereunder, in
addition to receiving the immediate return of the Deposit, Buyer shall also
be entitled to receive from Seller, Buyer's documented out-of-pocket costs
and expenses (including, but not limited to, reasonable attorney's fees)
actually incurred by Buyer to conduct the Environmental Studies, to negotiate
this Contract, and for acquisition and financing commitment and/or finder's
fees (such costs, "TRANSACTION COSTS"). Buyer covenants and agrees that any
Transaction Costs for which Buyer seeks payment under this Section 16.1 are
based on commercially reasonable terms and conditions negotiated with
unrelated third parties. Seller's maximum reimbursement liability for the
Transaction Costs shall not exceed an amount equal to Two Million Five
Hundred Thousand Dollars ($2,500,000). Buyer shall have the right to waive
any condition precedent to its obligation to proceed to Closing, in which
event the parties shall proceed to Closing without a reduction in the
Purchase Price.

                  16.2 DEFAULT BY BUYER. If Buyer defaults in its obligations to
close the purchase of the Property, or if Buyer otherwise materially defaults
hereunder, then (a) Seller shall be entitled to receive the Deposit, together
with all interest earned thereon, as fixed and liquidated damages, this Contract
shall terminate and neither party shall have any further liability hereunder,
except for those liabilities which expressly survive the termination of this
Contract, and (b) Buyer shall immediately direct the Escrow Agent, in writing,
to pay the Deposit to Seller. Seller shall have no other remedy for any default
by Buyer, including any right to damages. BUYER AND SELLER ACKNOWLEDGE AND AGREE
THAT (I) THE AMOUNT OF THE DEPOSIT IS A REASONABLE ESTIMATE OF AND BEARS A
REASONABLE RELATIONSHIP TO THE DAMAGES THAT WOULD BE SUFFERED AND COSTS INCURRED
BY SELLER AS A RESULT OF HAVING WITHDRAWN THE PROPERTY FROM SALE AND THE FAILURE
OF CLOSING TO HAVE OCCURRED DUE TO A

                                       18
<PAGE>

DEFAULT OF BUYER UNDER THIS CONTRACT; (II) THE ACTUAL DAMAGES SUFFERED AND
COSTS INCURRED BY SELLER AS A RESULT OF SUCH WITHDRAWAL AND FAILURE TO CLOSE
DUE TO A DEFAULT OF BUYER UNDER THIS CONTRACT WOULD BE EXTREMELY DIFFICULT
AND IMPRACTICAL TO DETERMINE; (III) BUYER SEEKS TO LIMIT ITS LIABILITY UNDER
THIS CONTRACT TO THE AMOUNT OF THE DEPOSIT IF THIS CONTRACT IS TERMINATED AND
THE TRANSACTION CONTEMPLATED BY THIS CONTRACT DOES NOT CLOSE DUE TO A DEFAULT
OF BUYER UNDER THIS CONTRACT; AND (IV) THE AMOUNT OF THE DEPOSIT SHALL BE AND
CONSTITUTE VALID LIQUIDATED DAMAGES AND NOT A PENALTY. All of the foregoing
shall be without limitation on the rights and remedies of Seller hereunder,
at law or in equity in the event of a default by Buyer pursuant to Sections
5.5 (Indemnification), 5.7 (Confidentiality), 18 (Litigation), or 21
(Brokerage), or any covenant, agreement, indemnity, representation or
warranty of Buyer that survives the Closing or the termination of this
Contract.

         17. SUCCESSORS AND ASSIGNS. Buyer may not assign its rights under this
Contract without the prior written approval of Seller, which approval Seller may
grant or withhold in its sole and absolute subjective discretion; PROVIDED,
HOWEVER, that Buyer shall have the right to assign its rights under this
Contract to an entity that will permit or facilitate off-balance sheet financing
of the Property for Buyer. In case of such permitted assignment, (a) Buyer
shall notify Seller and Escrow Agent in writing of the identity of the assignee
at least two (2) Business Days before the date of assignment and any other
information relating to such entity as Seller may reasonably request,
(b) between the Contract Date and the Closing Date, Buyer shall not be released
from any liability or obligations under this Contract on any such assignment,
it being understood and agreed that Buyer shall remain responsible for its
obligations under this Contract if Buyer so assigns this Contract, (c) after
the Closing Date, Buyer shall not be released from any liability or obligations
under Sections 5 (Environmental Inspection Period), 18 (Litigation),
21 (Brokerage), and 22.10.2 (Indemnification) of this Contract on any such
assignment, it being understood and agreed that Buyer shall remain responsible
for its obligations under those provisions of this Contract if Buyer so assigns
this Contract, and (d) the only entity that will occupy a portion of the
Property while Seller is the tenant under the Lease will be Buyer or an
affiliate of Buyer.

         18. LITIGATION. In the event of litigation between the parties with
respect to the Property, this Contract, the performance of their respective
obligations hereunder or the effect of a termination under this Contract, the
losing party shall pay all costs and expenses incurred by the prevailing party
in connection with such litigation, including, but not limited to, reasonable
attorneys' fees of counsel selected by the prevailing party. Notwithstanding any
provision of this Contract to the contrary, the obligations of the parties under
this Section 18 shall survive termination of this Contract.

         19. NOTICES. All notices, approvals, elections, offers, acceptances,
demands, consents, and reports (collectively, "NOTICE") provided for in this
Contract shall be in writing and shall be delivered to the addressee or to an
officer of the intended recipient as specified below:

                                       19
<PAGE>

<TABLE>
<S>                                   <C>
        IF TO SELLER:                  Invitrogen Corporation
                                       Attn:  Mr. Delano W. Tucker, Sr.
                                       9800 Medical Center Drive
                                       P.O. Box 6482
                                       Rockville, Maryland  20849-6482
                                       Facsimile:  301.610.8192

        WITH CONCURRENT COPIES TO:     Invitrogen Corporation
                                       Attention:  Mr. Troy W. Gardner
                                       Director Engineering Operations
                                       1600 Faraday Avenue
                                       Carlsbad, California  92008
                                       Facsimile:  760.603.7201

                                       AND

                                       Invitrogen Corporation
                                       Attn:  John A. Cottingham, Esquire
                                       9800 Medical Center Drive
                                       P.O. Box 6482
                                       Rockville, Maryland  20849-6482
                                       Facsimile:  301.610.8606

                                       AND

                                       Kevin L. Shepherd, Esquire
                                       Venable, Baetjer and Howard, LLP
                                       1800 Mercantile Bank and Trust Building
                                       Two Hopkins Plaza
                                       Baltimore, Maryland  21201-2978
                                       Facsimile:  410.244.7742

        IF TO BUYER:                   Human Genome Sciences, Inc.
                                       Attention:  Mr. Steven C. Mayer
                                       Senior Vice President and Chief Financial
                                       Officer
                                       9410 Key West Avenue
                                       Rockville, Maryland  20850
                                       Facsimile:  301.309.8512

                                       20
<PAGE>

        WITH CONCURRENT COPIES TO:     Alan S. Mark, Esquire
                                       Paley, Rothman, Goldstein, Rosenberg &
                                       Cooper, Chartered
                                       4800 Hampden Lane
                                       7th Floor
                                       Bethesda, Maryland 20814
                                       Facsimile:  301.654.7354

                                       AND

                                       James H. Davis, Esquire
                                       General Counsel
                                       Human Genome Sciences, Inc.
                                       9410 Key West Avenue
                                       Rockville, Maryland  20850
                                       Facsimile:  301.517.8831

        IF TO ESCROW AGENT:            Presidential Title, Inc.
                                       Attention:  Daniel P. Hodin, Esquire
                                       4800 Hampden Lane
                                       7th Floor
                                       Bethesda, Maryland 20814
                                       Facsimile:  301.654.7354
</TABLE>

         Each Notice or other communication may be mailed by United States
certified mail, return receipt requested, postage prepaid, or delivered by an
experienced and responsible nationally recognized overnight delivery company
(Federal Express, DHL Worldwide, Airborne Express, United Parcel Service and
Express Mail, United States Postal Service being deemed experienced and
responsible at the Contract Date) to the respective addresses set forth above.
If so mailed or delivered, then the Notice or other communication shall be
deemed to have been received by the addressee on the date of delivery or first
attempted delivery as shown on the U.S. Postal Service receipt or courier
invoice. The Notice or other communication may also be delivered by recognized
courier (by hand), or by telegraph, telex, or telecopier facsimile (with a
confirmation copy sent by one of the other Notice methods), in which case such
notices so delivered shall be effective on receipt during normal business hours.
Notices may be delivered on behalf of the parties by their respective attorneys.

         20. BENEFIT. This Contract is for the benefit only of the parties
hereto and the individuals specifically named in Section 7.2 and no other person
or entity shall be entitled to rely hereon, receive any benefit herefrom, or
enforce against any party hereto any provision hereof.

         21. BROKERAGE. Each party hereto represents and warrants to the other
that it has dealt with no brokers or finders in connection with this
transaction, except for Scheer Partners, Inc. ("BROKER"). Seller shall pay any
brokers' commission due to Broker pursuant to the terms

                                       21
<PAGE>

of a separate listing agreement between Seller and Broker. Seller and Buyer
each hereby indemnify, protect and defend and hold the other harmless from
and against all losses, claims, costs, expenses and damages (including, but
not limited to, reasonable fees of counsel selected by the indemnified party)
resulting from the claims of any broker, finder or other such party, other
than Broker, claiming by, through or under the acts or agreements of the
indemnifying party. The obligations of the parties pursuant to this Section
21 shall survive any termination of this Contract.

         22. MISCELLANEOUS.

                  22.1 ENTIRE AGREEMENT. This Contract constitutes the entire
understanding between the parties with respect to the transaction contemplated
herein, and all prior or contemporaneous oral agreements, understandings,
representations and statements, and all prior written agreements,
understandings, letters of intent (including, but not limited to, the letter of
intent dated February 7, 2001 among Seller, Buyer, and Broker) and proposals are
merged into this Contract. Neither this Contract nor any provisions hereof may
be waived, modified, amended, discharged or terminated except by an instrument
in writing signed by the party against which the enforcement of such waiver,
modification, amendment, discharge or termination is sought, and then only to
the extent set forth in such instrument.

                  22.2 TIME OF THE ESSENCE. TIME IS OF THE ESSENCE OF THIS
CONTRACT with respect to the parties obligation to proceed to Closing, and
Buyer's obligations to pay the Deposit to the Escrow Agent. If any date herein
set forth for the performance of any obligations by Seller or Buyer or for the
delivery of any instrument or notice as herein provided should be on a day that
is not a Business Day, the compliance with such obligations or delivery shall be
deemed acceptable on the next Business Day. For purposes of this Contract,
"BUSINESS DAY" means any day other than a Saturday, Sunday, or legal holiday on
which national banks are authorized by federal law to close.

                  22.3 GOVERNING LAW. This Contract shall be governed by and
construed in accordance with Maryland law, without regard to conflicts of laws
principles.

                  22.4 PARTIAL INVALIDITY. The provisions hereof shall be deemed
independent and severable, and the invalidity or partial invalidity or
enforceability of any one provision shall not affect the validity of
enforceability of any other provision hereof.

                  22.5 NO RECORDING. Neither this Contract nor any memorandum
thereof shall be recorded and the act of recording such instrument by Buyer
shall be deemed a material default by Buyer hereunder.

                  22.6 COUNTERPARTS. This Contract may be executed in multiple
counterparts and shall be valid and binding with the same force and effect as if
all parties had executed the same Agreement.

                  22.7 CONSTRUCTION OF AGREEMENT. In construing this Contract,
all headings and titles are for the convenience of the parties only and shall
not be considered a part of this

                                       22
<PAGE>

Contract. Whenever required by the context, the singular shall include the
plural and the masculine shall include the feminine and vice versa. This
Contract shall not be construed as if prepared by one of the parties, but
rather according to its fair meaning as a whole, as if both parties had
prepared it. All Exhibits attached hereto are incorporated in this Contract
by reference thereto.

                  22.8 NO ORAL MODIFICATION OR WAIVER. This Contract may not be
changed or amended orally, but only by an agreement in writing. No waiver shall
be effective hereunder unless given in writing, and waiver shall not be inferred
from any conduct of either party.

                  22.9 LIMITED LIABILITY. Neither the officers, employees, or
agents of Seller, nor the shareholders, officers, directors, employees or agents
of any of them shall be liable under this Contract and all parties hereto shall
look solely to the assets of Seller for the payment of any claim or the
performance of any obligation by Seller. Neither the shareholders, employees, or
agents of Buyer, nor the shareholders, officers, directors, employees or agents
of any of them shall be liable under this Contract and all parties hereto shall
look solely to the assets of Buyer for the payment of any claim or the
performance of any obligation by Buyer.

                  22.10 ESCROW AGENT.

                           22.10.1 RELIANCE. Escrow Agent may act in reliance on
any writing or instrument or signature that Escrow Agent, in good faith,
believes to be genuine, and may assume the validity and accuracy of any
statement or assertion contained in such a writing or instrument and may assume
that any person purporting to give any writing, notice, advice, or instruction
in connection with the provisions hereof has been duly authorized so to do.
Escrow Agent's duties hereunder shall be limited to the safe-keeping of the
Deposit and the disposition of the same in accordance with the terms hereof.

                           22.10.2 INDEMNIFICATION. Seller and Buyer, jointly
and severally, hereby agree to indemnify Escrow Agent and hold it harmless from
any and all claims, liabilities, losses, actions, suits, or proceedings at law
or in equity, or any other expense, fees, or charges of any character or nature,
which Escrow Agent may incur or with which Escrow Agent may be threatened by
reason of its acting as Escrow Agent under this Contract, and in connection
therewith, to indemnify Escrow Agent against any and all expenses, including
reasonable attorneys' fees and the cost of defending any actions, suit or
proceeding or resisting any claim.

                           22.10.3 COURT ACTION. If the parties hereto shall be
in disagreement about the interpretation of this Contract, or about their rights
and obligations hereunder, or the propriety of any action contemplated by Escrow
Agent hereunder, any party hereto may, at its discretion, file an action in a
court of competent jurisdiction to resolve such disagreement. Escrow Agent shall
be indemnified, jointly and severally, by Seller and Buyer for all costs,
including attorneys' fees, in connection with any such action, and shall be
fully protected in suspending all or a part of its activities under this
Contract until a final judgment, order, or decree in the action is received.

                                       23
<PAGE>

                           22.10.4 STANDARD OF CARE. Escrow Agent shall not
be liable for any mistakes of fact, or errors of judgment, or for any acts of
omission of any kind unless caused by the willful misconduct or negligence of
Escrow Agent.

         23.      MONTGOMERY COUNTY DISCLOSURES.

                  23.1 DISCLOSURE OF AIRPORT OR HELIPORT. Buyer acknowledges
that Seller has informed Buyer of the relative location of any airport or
heliport, as defined in the County zoning ordinance, existing within a five
(5) mile radius of the Property.

                  23.2 DISCLOSURE OF AVAILABILITY OF WATER AND SEWER SERVICE.
To Seller's Knowledge, the Property is connected to a community water and
sanitary sewer system.

                  23.3 NOTICE TO BUYER. Buyer is hereby notified that before
its execution of this Contract, Buyer has the right to examine the applicable
County master plan and any municipal land use plan for the area in which the
Property is located, and any adopted amendment to either plan, and approved
official maps showing planned land uses, roads and highways, parks, and other
public facilities affecting the property contained in the plan.

                  23.4 ACKNOWLEDGMENTS OF BUYER. BUYER HEREBY ACKNOWLEDGES
THAT: (A) SELLER HAS OFFERED BUYER THE OPPORTUNITY TO REVIEW THE APPLICABLE
MASTER PLAN AND MUNICIPAL LAND USE PLAN AND ANY ADOPTED AMENDMENT; (B) SELLER
HAS INFORMED BUYER THAT AMENDMENTS AFFECTING THE PLAN MAY BE PENDING BEFORE
THE PLANNING BOARD OR THE COUNTY COUNCIL OR A MUNICIPAL PLANNING BODY; (C)
BUYER HAS REVIEWED EACH PLAN AND ADOPTED AMENDMENT OR WAIVED THE RIGHT TO
REVIEW EACH PLAN AND ADOPTED AMENDMENT; AND (D) TO STAY INFORMED OF FUTURE
CHANGES IN COUNTY AND MUNICIPAL LAND USE PLANS, BUYER SHOULD CONSULT THE
PLANNING BOARD AND THE APPROPRIATE MUNICIPAL PLANNING BODY.

BUYER HEREBY FURTHER ACKNOWLEDGES THAT, TO STAY INFORMED OF FUTURE CHANGES IN
COUNTY AND MUNICIPAL WATER AND SEWER PLANS, BUYER SHOULD CONSULT THE COUNTY
PLANNING BOARD, THE WASHINGTON SUBURBAN SANITARY COMMISSION, THE COUNTY
DEPARTMENT OF ENVIRONMENTAL PROTECTION WITHOUT FURTHER CONFIRMATION OR
VERIFICATION, AND SELLER'S AGENT MAY RELY ON INFORMATION OBTAINED FROM SELLER
WITHOUT FURTHER CONFIRMATION OR VERIFICATION.

BUYER'S ACKNOWLEDGMENT:
                        ------------------------------

                    [SIGNATURE BLOCKS CONTAINED ON NEXT PAGE]

                                        24

<PAGE>

         IN WITNESS WHEREOF, the parties hereto have executed this Contract of
Sale on the date first above written with the specific intention of creating a
document under seal.

WITNESS:                                     INVITROGEN CORPORATION

/s/ John A. Cottingham                        By: /s/ Lewis J. Shuster (SEAL)
                                              Name: Lewis J. Shuster
                                              Title: Prsident, Genomics

WITNESS:                                      BUYER:  HUMAN GENOME SCIENCES,
                                              INC.

/s/ [ILLEGIBLE]                               By: /s/ Steven C. Mayer (SEAL)
                                                  Steven C. Mayer
                                                  Senior Vice President and
                                                  Chief Financial Officer

                                     JOINDER

         Escrow Agent joins in the execution of this Contract to evidence its
agreement to be bound by the terms and conditions hereof.

WITNESS:                                    PRESIDENTIAL TITLE, INC.

/s/ [ILLEGIBLE]                             By: /s/ David P. Hodin (SEAL)
                                            Name: David P. Hodin
                                            Title: President

                                        25

<PAGE>

                              SCHEDULE OF EXHIBITS

<TABLE>
<CAPTION>

                         EXHIBIT                    TITLE
<S>                                    <C>
                            A          Legal Description of the Land
                            B          Contracts
                            C          Deed
                            D          FIRPTA Affidavit
                            E          Assignment and Assumption of Contracts and Intangibles
                            F          Bill of Sale
                            G          Lease Agreement
                            H          Environmental Notice
                            I          List of Personal Property
                            J          Reaffirmation of Seller Representations
                            K          Reaffirmation of Buyer Representations
                            L          Matters to Resolve During Document Finalization Period

</TABLE>

                                        26

<PAGE>

                                    EXHIBIT A
                          LEGAL DESCRIPTION OF THE LAND

         The real property located in Montgomery County, Maryland, and
identified as Parcels W and O/R as shown on a plat entitled "Parcel `W and
O/R,' Shady Grove Life Sciences Center," recorded among the Land Records of
Montgomery County, Maryland in Plat Book 175, Plat 19634 in the Shady Grove
Life Sciences Center.

         Being the same property described in a Deed dated March 27, 1998,
and recorded on March 30, 1998 among the Land Records of Montgomery County,
Maryland in Liber 15676 at Folio 690.

                                        27
<PAGE>

                                    EXHIBIT B
                                    CONTRACTS

1.       Agreement to Fabricate, Transport, and Install A Work of Art
effective as of January 26, 1998 between Life Technologies, Inc. and Larry
Kirkland (relates to sculpture in lobby of R&D Building).

<TABLE>
<CAPTION>
     NAME                      ADDRESS 1           ADDRESS 2      CITY           STATE  ZIP           PHONE 1       PHONE 2
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
<S>  <C>                       <C>                 <C>            <C>            <C>    <C>         <C>             <C>
1.   ATLANTIC MEDICAL IMAGING  635 ERIE STREET                    HAVRE DE GRACE MD     21078       (800) 799-2600  (410) 378-
     SALES & SVC INC                                                                                                5281
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
2.   BECKMAN INSTRUMENTS       8920 ROUTE 108                     COLUMBIA       MD     21045
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
3.   BELL ATLANTIC MOBILE      P O BOX 64498                      BALTIMORE      MD     21264-4498  (908) 306-7282
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
4.   BIOSERVICE INC            435 CHRISTOPER      SUITE 21       GAITHERSBURG   MD     20879       (301) 977-6167
                               AVENUE
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
5.   CALVERT-JONES CO., INC.   5703 EDSALL ROAD    P.O. BOX       ALEXANDRIA     VA     22304-9229  (703) 370-5850  (703) 370-
                                                   22290                                                            8674
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
6.   CAREY MACHINERY & SUPPLY  P.O. BOX 64774                     BALTIMORE      MD     21264-4774  (410) 485-2323
     CO IN
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
7.   CARRIER SERVICE, INC.     PO BOX 83                          LEOLA          AR     72084       870 765-2691
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
8.   CONTINENTAL BUILDING      4265-D BROOKFIELD                  CHANTILLY      VA     20151       (703) 631-7300  (703) 968-
     MAINTENANCE, INC.         CORPORATE DRIVE                                                                      5674
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
9.   CUMMINS CHESAPEAKE        1907 PARK 100                      GLEN BURNIE    MD     21061-3274  (410) 633-5161  (410) 633-
     POWER, INC.               DRIVE                                                                                6031
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
10.  ENV SERVICES INC          P.O. BOX 13700                     PHILADELPHIA   PA     19191-1145  (800) 345-6094  (610) 337-
                                                                                                                    2267
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
11.  ESI INTERNATIONAL         4301 FAIRFAX DRIVE  SUITE 800      ARLINGTON      VA     22203
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
12.  ENVIRONMENTAL SUPPORT     1620 W.             Suite 100      TEMPE          AZ     85282       (602) 965-5043
     SOLUTIONS                 Fountainhead
                               Parkway
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
13.  FISHER LANDSCAPING INC.   19125 WOOTTON                      POOLESVILLE    MD     20837       (301) 407-0029  (301) 215-
                               AVENUE                                                                               0894
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
14.  GRIFFITH OIL              P. O. BOX 3109                     FREDERICK      MD     21705-3109  (800) 486-2477
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
15.  INSIGHT CALIBRATION       P.O. BOX 434                       MYERSVILLE     MD     21773
     SERVICES, INC.
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
16.  LANCASTER LABORATORIES    P.O. BOX 360184                    PITTSBURGH     PA     15251-6184  (717) 656-2300
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
17.  LBS CORPORATION           11408 PULASKI                      WHITE MARSH    MD     21162       (410) 335-6170
                               HIGHWAY
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
18.  MARYLAND FIRE EQUIPMENT   12284 WILKINS AVE                  ROCKVILLE      MD     20852
     CORP
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
19.  MID-ATLANTIC WASTE        P.O. BOX 64104                      BALTIMORE     MD     21264-4104  (410) 820-7188
     SYSTEMS
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
20.  MEDICAL EQUIPMENT &       12354 CARROLL AVE                  ROCKVILLE      MD     20852       (301) 881-2393
     MAINTENANCE CO
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
21.  NEU-ION, INC.             7200 RUTHERFORD                    BALTIMORE      MD     21244       (410) 944-5200
                               ROAD, SUITE 100
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
22.  OTIS ELEVATOR CO.         P.O. BOX 905454                    CHARLOTTE      NC     28290-5454
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
23.  PIONEER ROOFING SYSTEMS,  7211-C TELEGRAPH                   LORTON         VA     22079
     INC                       SQUARE DRIVE
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
24.  P.R. STEVENS, INC.        17601 CONOY ROAD                   BARNESVILLE    MD     20838
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
25.  QUALITY CALIBRATIONS,     1491-A GENERALS                    CROWNSVILLE    MD     21032       (410) 923-0600  (301) 912-
     INC.                      HIGHWAY                                                                              2252
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
26.  SIEMENS BUILDING          LANDIS & STAEFA,    6901 MUIRKIRK  BELTSVILLE     MD     20705       (301) 419-2613  (301) 206-
     TECHNOLOGY, INC.          INC                 MEADOWS                                                          2141
                                                   DRIVE
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
27.  THYSSEN GERNERAL          P.O. BOX 1702                      BALTIMORE      MD     21203       (301) 345-6100
     ELEVATOR
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
28.  UNICON SERVICES, INC.     P.O. BOX 877                       VIENNA         VA     22183       (703) 255-1259
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
29.  WATERS CORPORATION(MD)    P O BOX 101066                     ATLANTA        GA     30392-1066  (800) 252-4752
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
30.  WASTE MANAGEMENT OF       P.O. BOX 820803                    PHILADELPHIA   PA     19182-0803  (301) 340-0774
     MARYLAND
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
31.  WESTERN PEST SERVICES     11637 BOILING                       ROCKVILLE     MD     20852       (301) 468-9660  (301)
                               BROOK PLACE                                                                          8169365FAX
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------

                                       28

<PAGE>

     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
32.
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
33.  ACCUTECH SYSTEMS, INC.    704-A E GUDE                        ROCKVILLE     MD     20850       (301) 738-8290  (301) 738-
                               DRIVE                                                                                8296
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
34.  BURNS INT'L SECURITY      P.O. BOX 99477                     CHICAGO        IL     60693       (703) 448-3306
     SERVICES
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
35.  EUREST DINING SERVICES    3903 WASHINGTON                    BALTIMORE      MD     21227       (301) 309-9108
                               BLVD
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
36.  METROPOLITAN DUCT & FLUE  P.O. BOX 854                       GAITHERSBURG   MD     20884       (301) 428-3548  (301) 972-
     CLEANING SRVS                                                                                                  5942
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
37.  NATIONAL MAILING SYSTEMS  1749 OLD MEADOW                    MCLEAN         VA     22102-4310
                               ROAD SUITE 200
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
38.  KENNEDY FIRE PROTECTION   P.O. BOX 685        12 EAST 5TH    FREDERICK      MD     21701
                                                   STREET
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
39.  LAMINAR FLOW              100 GLENN DRIVE,                   STERLING       VA     20164       (703) 404-4300
     CONSULTANTS, INC.         A3
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
40.  MAGNOLIA PLUMBING, INC.   600 GALLATIN                       WASHINGTON     DC     20017
                               STREET, NE
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
41.  MOORE NORTH AMERICA       3040 WILLIAMS                      FAIRFAX        VA     22031       (703) 698-1566  (703) 280-
     (MOORE BUS.FORM)          DRIVE, SUITE 401                                                                     4906
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
42.  PINKERTON SERVICES GROUP  LOCK BOX NO. 2187   P.O. BOX       CAROL STREAM   IL     60197-4655  (800) 228-6966
                                                   4655                                             Receiva
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
43.  POSTMASTER                500 NORTH                          ROCKVILLE      MD     20850-9998
                               WASHINGTON
                               STREET
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
44.  REES SCIENTIFIC           1007 WHITEHEAD                     TRENTON        NJ     08638       (609) 530-1055
                               ROAD EXT
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
45.  ROCKVILLE MAILING         751 EAST GUDE                      ROCKVILLE      MD     20850-1387  (301) 279-0606
     SERVICE INC               DRIVE
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
46.  V&F COFFEE INC.           7600 M FULLERTON                   SPRINGFIELD    VA     22153       (703) 569-9500
                               ROAD
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
47.  XEROX CORPORATION(MD)     P.O. BOX 827598                    PHILADELPHIA   PA     19182-7598  (800) 822-2200
     ------------------------  ------------------  ------------   -------------- -----  ----------  --------------  ----------
</TABLE>

                                       29
<PAGE>

                                    EXHIBIT C
                                      DEED

         THIS DEED ("THIS DEED"), dated as of ___________ ___, 2001, from
INVITROGEN CORPORATION, a Delaware corporation ("GRANTOR"), to _____________,
a ____________ ("GRANTEE").

         Grantor, in consideration of the payment of Fifty-Five Million Dollars
($55,000,000), grants, conveys, and assigns to Grantee, its successors and
assigns, in fee simple, the real property located in Montgomery County,
Maryland, and identified as Parcels W and O/R as shown on a plat entitled
"Parcel `W and O/R,' Shady Grove Life Sciences Center," recorded among the Land
Records of Montgomery County, Maryland in Plat Book 175, Plat 19634 in the Shady
Grove Life Sciences Center.

         BEING the same property described in a Deed dated March 27, 1998,
and recorded on March 30, 1998 among the Land Records of Montgomery County,
Maryland in Liber 15676 at Folio 690. [ADD REFERENCE TO CONFIRMATORY DEED]

         SUBJECT TO all covenants, conditions, easements, reservations, liens,
exceptions, and all other restrictions of record; zoning ordinances and
subdivision regulations and laws; and taxes and assessments, both general and
special, not yet due and payable, including, but not limited to, those matters
listed on RIDER I attached hereto as a part hereof.

         TOGETHER WITH the rights, alleys, ways, waters, easements, privileges,
appurtenances, and advantages belonging or appertaining thereto.

         TO HAVE AND TO HOLD the Property hereby conveyed to Grantee, its
successors and assigns, in fee simple, forever.

         GRANTOR COVENANTS TO WARRANT SPECIALLY the property hereby conveyed,
and to execute such further assurances of the property as may be requisite.

         IN WITNESS WHEREOF, Grantor has executed this Deed as of the date first
above written with the specific intention of creating a document under seal.

WITNESS:                                    INVITROGEN CORPORATION

__________________________________          By:_________________________(SEAL)
                                            Name:_____________________________
                                            Title:____________________________

                  [ADD AFFIDAVIT OF CONSIDERATION, IF APPLICABLE]

                                       30
<PAGE>

STATE OF MARYLAND, COUNTY OF MONTGOMERY, to wit:

         I HEREBY CERTIFY that on _________________, 2001, before me, a Notary
Public of the State of Maryland, personally appeared _________________________,
who acknowledged himself to be a Vice President of Invitrogen Corporation
("CORPORATION"), and that he, as such Vice President, being authorized so to do,
executed the foregoing Deed for the purposes therein contained by signing, in my
presence, the name of the Corporation by himself as Vice President, and
certified that this conveyance is not part of a transaction in which there is a
sale, lease, exchange, or other transfer of all or substantially all of the
property and assets of the Corporation.

         In witness whereof I hereunto set my hand and official seal.

                                            _________________________________
                                            Notary Public

My commission expires: ____________________

                                  CERTIFICATION

                  I HEREBY CERTIFY THAT I, the undersigned, an attorney at law
who has been admitted to practice before the Maryland Court of Appeals, has
prepared the within instrument.

                                      _______________________________________
                                      Kevin L. Shepherd, Esquire

                                       31
<PAGE>

<TABLE>
<S>                              <C>
-------------------------------------------------------------------------------
TAX I.D. NUMBER:                 9-1-3095087

-------------------------------------------------------------------------------
AFTER RECORDING RETURN TO:       Kevin L. Shepherd, Esquire
                                 Venable, Baetjer and Howard, LLP
                                 1800 Mercantile Bank and Trust Building
                                 Two Hopkins Plaza
                                 Baltimore, Maryland  21201-2978
-------------------------------------------------------------------------------

PROPERTY ADDRESS:                9800 Medical Center Drive
                                 P.O. Box 6482
                                 Rockville, Maryland  20849-6482
-------------------------------------------------------------------------------

GRANTOR'S ADDRESS:               Invitrogen Corporation
                                 Attn:  Mr. Delano W. Tucker, Sr.
                                 9800 Medical Center Drive
                                 P.O. Box 6482
                                 Rockville, Maryland  20849-6482
-------------------------------------------------------------------------------

GRANTEE'S ADDRESS:               _________________________
                                 _________________________
                                 _________________________

-------------------------------------------------------------------------------
TITLE INSURER:                   Commonwealth Land Title Insurance Company
                                 c/o Presidential Title, Inc.
                                 Seventh Floor
                                 4800 Hampden Lane
                                 Bethesda, Maryland  20814
-------------------------------------------------------------------------------
</TABLE>

                                       32
<PAGE>

                                     RIDER I
                              PERMITTED EXCEPTIONS

<TABLE>
<S>      <C>
1.       Easement and/or Right of Way granted to Washington Suburban Sanitation
         Commission by Agreement dated April 23, 1975, and recorded in Liber
         4651, at folio 265.

2.       Agreement by and between Montgomery County, Maryland and the Washington
         Suburban Sanitation Commission dated February 11, 1977 and recorded in
         Liber 4931, at folio 642.

3.       Agreement by and between Montgomery County, Maryland and the Washington
         Suburban Sanitation Commission dated December 13, 1977 and recorded in
         Liber 5077, at folio 685.

4.       Agreement by and between Montgomery County, Maryland and the Washington
         Suburban Sanitation Commission dated January 1985 and recorded in Liber
         6668, at folio 43 and re-recorded in Liber 7037, at folio 737.

5.       Deed of Easement by and between Montgomery County, Maryland and Potomac
         Electric Power Company and The Chesapeake and Potomac Telephone Company
         of Maryland dated January 29, 1977 and recorded in Liber 7537, at folio
         410.

6.       Amended and Restated Declaration of Covenants and Easements by and
         between Montgomery County, Maryland and Redgate II Limited Partnership
         dated March 9, 1990 and recorded in Liber 9332, at folio 591.

7.       Easement and/or Right of Way granted to the Washington Suburban
         Sanitation Commission by Agreement dated March 7, 1990 and recorded in
         Liber 9344, at folio 509.

8.       Storm water management easement, 55' slope easement, 25' drainage
         easement, 12' utility easement, and 8' construction strip as shown on
         the Plat recorded in Plat Book 101 at Plat 11465.

9.       Terms, conditions, easements, reservations, and restrictions as shown
         on the Plat entitled "Parcel `W O/R' SHADY GROVE LIFE SCIENCES CENTER"
         which plat is recorded in Plat Book 175 at Plat No. 19634, including
         (i) minimum building restriction line established by plat, (ii) 50'
         temporary slope easement established by plat, and (iii) vehicular
         access denied along Shady Grove Road and Great Seneca Highway by note
         on plat.
</TABLE>

                                       33
<PAGE>

                                  EXHIBIT D
                    NON-FOREIGN CERTIFICATE (FIRPTA AFFIDAVIT)

                        CERTIFICATE OF NONFOREIGN STATUS
       (PURSUANT TO I.R.C. SECTION 1445 AND TREAS. REG. SECTION 1.1445-2)

         Section 1445 of the Internal Revenue Code provides that a transferee of
a U.S. real property interest must withhold tax if the transferor is a foreign
person. To inform the transferee that withholding of tax is not required upon
the disposition of a U.S. real property interest by INVITROGEN CORPORATION, a
Delaware corporation (the "CORPORATION"), the undersigned hereby certifies the
following on behalf of the Corporation:

         1.    The Corporation is not a foreign corporation, foreign
partnership, foreign trust, or foreign estate (as those terms are defined in
the Internal Revenue Code and Income Tax Regulations);

         2.    The Corporation's U.S. employer identification number is
_________; and

         3.    The Corporation's office address is as follows:

                          Invitrogen Corporation
                          9800 Medical Center Drive
                          P.O. Box 6482
                          Rockville, Maryland  20849-6482

         The Corporation understands that this certification may be disclosed to
the Internal Revenue Service by the transferee and that any false statement
contained herein could be punished by fine, imprisonment, or both.

         Under penalties of perjury I declare that I have examined this
certification and, to the best of my knowledge and belief, it is true, correct
and complete, and I further declare that I have authority to sign this document
on behalf of the Corporation.

WITNESS:                                    INVITROGEN CORPORATION

___________________________________         By:___________________________(SEAL)
                                            Name:_______________________________
                                            Title:______________________________

DATED:  ______________ ___, 2001

                                       34
<PAGE>

                                  EXHIBIT E
             ASSIGNMENT AND ASSUMPTION OF CONTRACTS AND INTANGIBLES

         THIS ASSIGNMENT AND ASSUMPTION OF CONTRACTS AND INTANGIBLES ("THIS
ASSIGNMENT") is made and entered into this ____ day of __________, 2002, by and
between INVITROGEN CORPORATION, a Delaware corporation ("ASSIGNOR"), and
_____________, a _______________ ("ASSIGNEE").

                            EXPLANATORY STATEMENT

         A. Assignor and Assignee entered into that certain Contract of Sale
dated as of March 7, 2001, as amended from time to time (as amended, the
"CONTRACT"), for the purchase and sale of 9800 Medical Center Drive, Rockville,
Maryland 20849 (the "PREMISES").

         B. In connection with the consummation of the transactions contemplated
under the Agreement, Assignor and Assignee desire to execute this Assignment.

         NOW, THEREFORE, in consideration of good and valuable consideration,
the receipt and sufficiency of which are hereby acknowledged, the parties agree
as follows:

         1. EXPLANATORY STATEMENT; DEFINED TERMS. The foregoing Explanatory
Statement is hereby incorporated as if fully rewritten and restated in the body
of this Assignment. Capitalized terms used herein and not otherwise defined
shall have the meanings respectively ascribed to them in the Contract.

         2. ASSIGNMENT OF CONTRACTS AND INTANGIBLES. Assignor hereby sells,
transfers, conveys, and assigns to Assignee all of Assignor's right, title, and
interest in and to any and all contracts and agreements relating to the
management, leasing, operation, maintenance and repair of the Premises set forth
on RIDER 1 attached hereto and made a part hereof (collectively, the
"CONTRACTS"), SUBJECT, HOWEVER, to the terms and covenants of the Contracts and
this Assignment. Assignor hereby quitclaims unto Assignee, without recourse,
representation or warranty of any kind whatsoever, all of Assignor's right,
title, and interest (if any) in and to all, if any, Intangibles relating to the
Premises. Such Intangibles are quitclaimed by Assignor to Assignee on an "AS-IS"
"WHERE-IS", "WITH ALL FAULTS" basis, and without any warranties,
representations, or guaranties either express or implied, of any kind, nature,
or type whatsoever, except the foregoing shall be without limitation on any
representations and warranties expressly contained in the Contract.

         3. ASSUMPTION OF OBLIGATIONS. Assignee hereby accepts the assignment of
the Contracts and the Intangibles subject to the terms and conditions hereof,
and from and after the date hereof, Assignee hereby assumes and shall be
responsible for and shall perform, discharge, and fulfill all of the obligations
imposed on Assignee, as the owner of the Premises and the successor-in-interest
to Assignor, under the Contracts, which obligations accrue after the date
hereof.

                                       35
<PAGE>

         4. ASSIGNEE'S INDEMNIFICATION. Assignee agrees to and hereby does
indemnify, protect, defend, and hold Assignor, the officers, directors, and
shareholders of Assignor, and all of their respective successors and assigns
harmless from any and all claims, damages, losses, suits, proceedings, costs,
and expenses (including, without limitation, reasonable attorneys' fees)
(collectively, the "LOSSES"), both known or unknown, present and future, at law
or in equity, arising out of, by virtue of, or in any way related to the breach
by Assignee of (or Assignee's failure to timely perform) any or all of the
obligations imposed on Assignee, as the owner of the Premises and the
successor-in-interest to Assignor, under the Contracts, which obligations
accrue after the date hereof.

         5. ASSIGNOR'S INDEMNIFICATION. Assignor agrees to and hereby does
indemnify, protect, defend, and hold Assignee, Assignee's shareholders, the
partners, officers, directors, and shareholders of Assignee's shareholders and
all of their respective successors and assigns harmless from any and all Losses,
both known and unknown, present and future, at law or in equity arising out of,
by virtue of or related in any way to the breach by Assignor of (or Assignor's
failure to timely perform) any or all of the obligations imposed on Assignor, as
the owner of the Premises before the date hereof, under the Contracts, which
obligations accrued on or before the date hereof.

         6. COUNTERPARTS. This Assignment may be executed in one or more
multiple counterparts, all of which, when taken together shall constitute one
and the same instrument.

         7. GOVERNING LAW. This Assignment shall be governed by and construed in
accordance with Maryland law.

         8. PARTIAL INVALIDITY. The provisions hereof shall be deemed
independent and severable, and the invalidity or enforceability of any one
provision shall not affect the validity or enforceability of any other provision
hereof.

         IN WITNESS WHEREOF, the parties hereto have executed this Assignment on
the date first above written with the specific intention of creating a document
under seal.

WITNESS:                                          ASSIGNOR: INVITROGEN
                                                  CORPORATION

___________________________________               By:____________________(SEAL)
                                                  Name:________________________
                                                  Title:_______________________

                                       36
<PAGE>

WITNESS:                                          ASSIGNEE:

___________________________________               By:____________________(SEAL)
                                                  Name:________________________
                                                  Title:_______________________

                                       37
<PAGE>

                                     RIDER 1
                           LIST OF ASSIGNED CONTRACTS

            [ATTACH LIST IN EFFECT AS OF THE LEASE EXPIRATION DATE]

                                       38
<PAGE>

                                    EXHIBIT F
                             QUITCLAIM BILL OF SALE

         FOR VALUE RECEIVED, INVITROGEN CORPORATION, a Delaware corporation
("SELLER"), hereby quitclaims unto _________________, a ________________
("BUYER"), all of Seller's right, title, and interest, if any, in and to all
Personal Property [as defined in the Contract of Sale dated March 7, 2001
between Seller and Buyer]. The Personal Property is quitclaimed by Seller to
Buyer on an "AS IS," "WHERE IS," "WITH ALL FAULTS" basis, and without any
warranties, representations, or guarantees, either express or implied, of any
kind, nature, or type whatsoever, including, but not limited to, any warranty as
to the fitness for a particular purpose or merchantability of the Personal
Property.

         IN WITNESS WHEREOF, Seller has executed this Bill of Sale as of
_________ __, 2001.

WITNESS:                                          INVITROGEN CORPORATION

___________________________________               By:____________________(SEAL)
                                                  Name:________________________
                                                  Title:_______________________

                                       39
<PAGE>

                                    EXHIBIT G
                             FORM OF LEASE AGREEMENT

                         [ATTACH CURRENT FORM OF LEASE]

                                       40
<PAGE>

                                    EXHIBIT H
                              ENVIRONMENTAL NOTICES

Notice of violation of air pollution regulations dated December 9, 1997 issued
by the State of Maryland, Department of the Environment, Air & Radiation
Management Administration.

                                       41
<PAGE>

                                    EXHIBIT I
                            LIST OF PERSONAL PROPERTY

Seller and Buyer to agree on list of Personal Property during the Document
Finalization Period.

[Make sure list excludes one (1) 50 liter ABEC fermenter]

                                       42
<PAGE>

                                    EXHIBIT J
                     REAFFIRMATION OF SELLER REPRESENTATIONS

                                  REAFFIRMATION

         INVITROGEN CORPORATION, a Delaware corporation ("SELLER"), hereby
reaffirms to Human Genome Sciences, Inc. ("BUYER") that the Seller
Representations (as defined in the Contract of Sale dated March 7, 2001 between
Seller and Buyer) are true and correct in all material respects as of the date
hereof.

         IN WITNESS WHEREOF, Seller has duly executed this Reaffirmation
effective as of ______________ __, 2001.

WITNESS:                                    INVITROGEN CORPORATION

_________________________________           By:_____________________(SEAL)
                                            Name:_________________________
                                            Title:________________________

                                       43
<PAGE>

                                    EXHIBIT K
                     REAFFIRMATION OF BUYER REPRESENTATIONS

                                  REAFFIRMATION

         [HUMAN GENOME SCIENCES, INC., a Delaware corporation] ("BUYER"), hereby
reaffirms to Invitrogen Corporation ("SELLER") that the representations and
warranties of Buyer contained in Section 8 of the Contract of Sale dated March
7, 2001 between Seller and Buyer are true and correct in all material respects
as of the date hereof.

         IN WITNESS WHEREOF, Buyer has duly executed this Reaffirmation
effective as of ______________ __, 2001.

WITNESS:                                    HUMAN GENOME SCIENCES, INC.

_________________________________           By:_____________________(SEAL)
                                            Name:_________________________
                                            Title:________________________

                                       44
<PAGE>

                                    EXHIBIT L
             MATTERS TO RESOLVE DURING DOCUMENT FINALIZATION PERIOD

         Set forth below is a list of items that Seller and Buyer are to use
their reasonable and good faith efforts to resolve during the Document
Finalization Period (i.e., March 7, 2001 through March 22, 2001):

<TABLE>
<CAPTION>

-----------------------------------------------------------------------------------
                         MATTER                          SECTION REFERENCE
-----------------------------------------------------------------------------------
<S>                                                    <C>
1.   Finalize list of Contracts (EXHIBIT B)                      1.4
-----------------------------------------------------------------------------------
2.   Finalize list of Personal Property (EXHIBIT I)              1.3
-----------------------------------------------------------------------------------
3.   Finalize allocation of Purchase Price                        2
-----------------------------------------------------------------------------------
4.   Finalize form of Lease (EXHIBIT G)                         11.2
-----------------------------------------------------------------------------------
</TABLE>

                                       45

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00025-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00025-of-00352.parquet"}], [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00025-of-00352.parquet"}], [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00025-of-00352.parquet"}]]