Document:

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                                                                   EXHIBIT 10.17

                      JOINT VENTURE SHAREHOLDERS' AGREEMENT

                              Dated August 31, 2000

                                     PARTIES

                                 PHARMAPRINT INC

                                       AND

                                  CAPITAL ALERT
                                 INVESTMENT LTD

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AGREEMENT made the 31 day of August, 2000

PARTIES PHARMAPRINT INC.

        of 4701 Von Karman Avenue, Suite 201, Newport Beach, California 926660,
        United States of America ("PARTY A")

AND     CAPITAL ALERT INVESTMENTS LTD of PO Box 957, Offshore Incorporations
        Center, Road Town, Tortola, British Virgin Islands ("PARTY B")

INTRODUCTION

A.      Party A develops, manufactures and markets dietary supplements,
        functional foods, and pharmaceuticals derived from natural plant
        extracts. Party A's proprietary PharmaPrint(TM) Process technology
        enables the precise identification and consistent replication of the
        active ingredients from these extracts that are scientifically believed
        to provide the desired health benefits.

B.      Party B is a company directly or indirectly invested in business
        ventures in Hong Kong and other Asia Pacific countries and cities.

C.      Party A and Party B have agreed to enter into a joint venture for the
        purpose of developing, marketing, and distributing the Products
        manufactured under the PharmaPrint(TM) Process technology in the
        Territory through the Company.

IT IS AGREED

1.      DEFINITIONS AND INTERPRETATION

1.1     DEFINITIONS

        In this Agreement:

        (1)     "Agreement" means this document, including any schedule or
                annexure to it;

        (2)     "Annual Program" means a program to carry out the business of
                the Company during a financial year and will consist of:

                (a)     a business plan setting out in reasonable detail the
                        proposed marketing plans, finance arrangements, capital
                        expenditures and activities to carry on the business of
                        the Company during the financial year; and

                (b)     a budget setting out in reasonable detail an estimate of
                        the income to be received and the expenses to be
                        incurred in carrying out that business plan;

        (3)     "Article" means an article in the Constitution;

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        (4)     "Auditors" means the auditors of the Company, if any;

        (5)     "Board" or "Directors" means the board of directors of the
                Company meeting as a board in accordance with the Constitution;

        (6)     "Business Day" means a day that is not a Saturday, Sunday or any
                other day which is a public holiday or a bank holiday in the
                place where an act is to be performed or a payment is to be
                made;

        (7)     "Commencement Date" means the date specified in Item 1 of the
                schedule, or such later date as is agreed in writing by the
                Parties;

        (8)     "Company" means the company the Parties incorporate under clause
                2.1;

        (9)     "Constitution" means the constitution to be adopted by the
                Company on or before the Effective Date which shall contain the
                terms mentioned in Annexure A and as amended from time to time;

        (10)    "Director" means a director of the Company from time to time;

        (11)    "Dispose" includes, in relation to a Share, to enter into a
                transaction in relation to the Share (or any interest in the
                Share), which results, or will result, in a person other than
                the registered holder of the Share:

                (a)     acquiring any equitable interest in the Share, including
                        an equitable interest arising from a declaration of
                        trust, an agreement for sale and purchase or an option
                        agreement or an agreement creating a charge or other
                        security interest in the Share;

                (b)     acquiring any right to receive directly or indirectly
                        any Dividends payable in respect of the Share;

                (c)     acquiring any rights of pre-emption, first refusal or
                        like control over the disposal of the Share;

                (d)     acquiring any rights of control over the exercise of any
                        voting rights or rights to appoint Directors attaching
                        to the Share; or

                (e)     otherwise acquiring legal or equitable rights against
                        the registered holder of the Share which have the effect
                        of placing the person in the same position as if the
                        person had acquired a legal or equitable interest in the
                        Share itself;

        (12)    "Dividend" includes a bonus distribution in specie or in cash;

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        (13)    "Effective Date" means the date specified in Item 2 of the
                schedule, or such other date as is agreed in writing by the
                Parties;

        (14)    "Encumbrance" means any mortgage, pledge, lien, hypothecation,
                charge or other form of security interest or interest in the
                nature of a security interest;

        (15)    "Initial Annual Program" means the Annual Program for the period
                from the Effective Date and ending on 30 June 2001 to be agreed
                by the Parties in accordance with clause 3.1;

        (16)    "Initial Directors" means the persons named in clause 22.2;

        (17)    "Licence and Distribution Agreement" means the agreement to be
                made between Party A, a company incorporated under the laws of
                Delaware, USA, and the Company pursuant to which Party A grants
                the Company the license and right to use the PharmaPrint(TM)
                Process technology and to manufacture, distribute and market the
                Product manufactured by using the PharmaPrint(TM) Process
                technology in the Territory, substantially in the form of the
                document in Annexure B;

        (18)    "Loans" includes, in relation to loans to the Company made by a
                Shareholder which is a body corporate, loans to the Company made
                by any Related Company of that Shareholder;

        (19)    "New Company Name" means "Kingsway PharmaPrint Asia Limited" or
                such other name determined by the Parties;

        (20)    "Operative Agreements" means all agreements that are exhibits to
                this Agreement and such other agreements that the Parties enter
                into for the purpose of fostering the Company.

        (21)    "Party" means a party to this Agreement and includes a person
                who executes a deed agreeing to become bound by the terms of
                this Agreement;

        (22)    "Product" means the dietary supplements, functional foods and
                pharmaceuticals derived from natural plant extracts produced by
                using the PharmaPrint(TM) Process technology;

        (23)    "Related Company" in respect of a company means its Subsidiary,
                its Holding Company or another company within the same Group of
                Companies as the first mentioned company;

        (24)    "Share" means a share of the Company's capital stock;

        (25)    "Shareholder" means a Party who holds Shares from time to time;

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        (26)    "Share Subscription Agreement" means the agreement between Party
                A and Party B pursuant to which Party B shall purchase that
                number of shares of Party A's capital stock for the purchase
                price set forth in such agreement.

        (27)    "Subsidiary", "Holding Company" and "Group of Companies" each
                has the same meaning as in section 2 of the Companies Ordinance
                (Cap.32)-

        (28)    "Territory" means the territory described in Item 6 of the
                schedule.

1.2     INTERPRETATION

        (1)     Reference to:

                (a)     one gender includes the others;

                (b)     the singular includes the plural and the plural includes
                        the singular;

                (c)     a person includes a body corporate;

                (d)     a Party includes the Party's executors, administrators,
                        successors and permitted assigns;

                (e)     a statute, regulation or provision of a statute or
                        regulation ("Statutory Provision") includes:

                        (i)     that Statutory Provision as amended or
                                re-enacted from time to time; and

                        (ii)    a statute, regulation or provision enacted in
                                replacement of that Statutory Provision; and

                (f)     money is to United States dollars, unless otherwise
                        stated.

        (2)     "Including" and similar expressions are not words of limitation.

        (3)     Where a word or expression is given a particular meaning, other
                parts of speech and grammatical forms of that word or expression
                have a corresponding meaning.

        (4)     Headings are for convenience only and do not form part of this
                Agreement or affect its interpretation.

        (5)     If an act must be done on a specified day which is not a
                Business Day, the act must be done instead on the next Business
                Day.

1.3     PARTIES

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        (1)     If a Party consists of more than 1 person, this Agreement binds
                each of them separately and any 2 or more of them jointly.

        (2)     An obligation, representation or warranty in favor of more than
                1 person is for the benefit of them separately and jointly.

        (3)     A Party which is a trustee is bound both personally and in its
                capacity as a trustee.

INTRODUCTORY MATTERS AND CONDITIONS PRECEDENT

2.      ESTABLISHMENT OF COMPANY

2.1     On or before the Effective Date Party A and Party B must procure:

        (1)     the incorporation in the British Virgin Islands of a company
                with the New Company Name;

        (2)     the adoption by the Company of the Constitution;

        (3)     the appointment of the Initial Directors at a duly authorised
                meeting; and

        (4)     the allotment to Party A and Party B of the Shares.

2.2     Unless otherwise decided by the Board:

        (1)     the Auditors are PricewaterhouseCoopers;

        (2)     the company secretary is Bill Lam & Associates Limited, a
                company incorporated under the jurisdiction of Hong Kong; and

        (3)     the financial year of the Company commences on 1 July of each
                year and terminates on 30 June of the following year.

2.3     Party A and Party B must take steps commercially reasonable for the
        Company to commence operations on or before the Effective Date.

2.4     The Board must decide upon the following no later than 3 months after
        the signing of this Agreement

        (1)     management structure;

        (2)     marketing strategy;

        (3)     staffing levels;

        (4)     funding requirements;

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        (5)     accounting/administration procedures;

        (6)     electronic data and document processing;

        (7)     bankers and insurers;

        (8)     premises from which the Company operates; and

        (9)     adoption of the Initial Annual Program.

3.      CONDITION PRECEDENT TO THE EFFECTIVE DATE

3.1     The Licence and Distribution Agreement must have been entered into
        between Party A and the Company.

3.2     The Share Subscription Agreement must have been entered into between
        Party A and Party B.

PURPOSE OF THE JOINT VENTURE COMPANY

4.      PURPOSE

4.1     The purpose of the Company is:

        (1)     manufacture, distribute, enrol and market the Product in the
                Territory as provided by Party A;

        (2)     to consider the viability of further joint operations; and

        (3)     to undertake any future developments and operations which are
                economically viable and which are agreed by the Board and within
                the purposes of the Company.

CONTRIBUTIONS TO JOINT VENTURE

5.      CONTRIBUTIONS TO SHARE CAPITAL OF THE COMPANY

5.1     On or before the Effective Date Party A shall have made initial capital
        contributions to the Company consisting of United States of America
        Dollar Five Hundred Thousand (US$500,000), the technology contributions
        contemplated by the Licence and Distribution Agreement, and have entered
        into the Operative Agreements, including, without limitation, the Share
        Subscription Agreement, in exchange for the number of Shares set out in
        Item 3 of the Schedule. The transfer of funds pursuant to this clause
        5.1 shall occur without any further action on the part of Party A upon
        the execution of this Agreement, the License and Distribution Agreement
        and the investment (the "Investment") by Party B in Party A pursuant to
        the Share Subscription Agreement.

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        Party A acknowledges and authorizes the transfer to the Company of funds
        from the Investment held on Party A's behalf in any escrow or trust fund
        necessary to make the capital contribution described in this clause 5.1.

5.2     On or before the Effective Date Party B must have agreed to contribute
        the local knowledge, office space, necessary personnel and support
        services to the Company for a period of one (1) year from the Effective
        Date, and have entered into the Operative Agreements, including, without
        limitation, the Share Subscription Agreement, in return for the
        allotment of the number of fully paid-up Shares set out in Item 4 of the
        schedule.

5.3     Immediately after the Effective Date the authorised and paid up capital
        of the Company must be the amounts set out in Item 5 of the schedule.

5.4     Except as set forth in Clauses 5.1 and 5.3 above, no Party shall be
        required to make any additional capital contribution to the Company. In
        the event the Company makes a request for capital contributions in
        excess of the amount set forth in Clauses 5.1 and 5.2 above, each Party
        shall have a pre-emptive right to participate in such capital
        contribution up to its pro rata portion to avoid dilution. If a Party
        declines to fund its pro rata portion of such capital contribution
        within thirty (30) days of notice of such capital contribution, the
        other Party or third parties may purchase such shares in the Company's
        sole discretion.

6.      LEGAL AND ESTABLISHMENT COSTS

6.1     The Company must pay:

        (1)     all legal costs and statutory charges incurred in connection
                with the incorporation of the Company and the preparation and
                execution of all documents (other than this Agreement and the
                Operative Agreements) required for the joint venture and the
                establishment of the Company ("Legal Costs"); and

        (2)     all other costs relating to the establishment of the joint
                venture which the Board resolves, prior to the Effective Date,
                are payable by the Company ("Establishment Costs").

7.      FURTHER FINANCING

7.1     Party B may undertake to provide to the Company any further finance or
        to severally guarantee loans to the Company from third parties which the
        Company reasonably requires by way of working capital. The further
        finance may be provided only as resolved by the Board.

7.2     Further financial requirements of the Company may be provided by way of:

        (1)     additional capital subscribed by Party B;

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        (2)     Loan from Party B; or

        (3)     overdraft or other borrowing or financial accommodation from
                third parties;

        only as resolved by the Board.

7.3     Any Loan provided by a Shareholder must be on arm's length commercial
        terms.

8.      GUARANTEES AND INDEMNITIES

        If any Shareholder Disposes of all its Shares to any of the other
        Shareholders the Shareholders acquiring those Shares must use all
        reasonable endeavors to obtain the release of the Disposing Shareholder
        from any guarantees and indemnities given under this Agreement or with
        the written consent of the Shareholders in respect of any of the
        liabilities or obligations of the Company to third parties and pending
        the obtaining of that release must keep the disposing Shareholder fully
        and effectively indemnified against any liability under the guarantees
        or indemnities.

9.      EXPERTISE - PARTY A

        In furtherance of the purpose of the Company Party A and its Related
        Company must bring to the Company:

        (1)     expertise and know-how in respect of the development,
                manufacture and marketing of the Product;

        (2)     knowledge, expertise and experience in the pharmaceutical
                business; and

        (3)     knowledge and experience in the registration of patent rights
                related to the Product in the U.S. and in the Territory.

10.     EXPERTISE - PARTY B

        In furtherance of the purpose of the Company, Party B must bring to the
        Company:

        (1)     knowledge, expertise and experience in the marketing and
                distribution business;

        (2)     expertise in the management of a company engaged in the
                marketing and distribution business;

        (3)     knowledge and expertise concerning the market in the Territory,
                the customs of the people and its ability to service those
                people.

SEPARATE RELATIONS OF SHAREHOLDERS TO COMPANY

11.     DEALINGS OF SHAREHOLDERS WITH COMPANY

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11.1    The Shareholders must use their best endeavors to ensure that they and
        any Related Bodies Corporate give and are given every opportunity to do
        business with the Company on a commercial basis.

11.2    The Shareholders must use their best endeavors to ensure that the
        operation of the Company is supported by those activities over which
        they have control through ownership, affiliation, association or
        contractual arrangements. However, nothing in this clause 11.2 abrogates
        or limits the rights of a Shareholder to determine the method of
        managing its own business.

11.3    In the event the Company undertakes to list its Shares, or the shares of
        any Subsidiary, on any public exchange or electronic trading system in
        any jurisdiction upon the approval of the Company Board, each Party
        shall, and shall cause its officers, directors, employees, agents and
        Related Companies to, cooperate fully with all requests of the Company
        to effectuate such listing.

12.     SHAREHOLDER'S ACCESS TO ACCOUNTS AND RECORDS

        After giving at least five (5) Business Days' notice to the Company,
        each Shareholder will be entitled to full access during the Company's
        normal business hours through an accountant, agent or employee of that
        Shareholder and at that Shareholder's cost to inspect all the books,
        accounts, records and facilities of the Company for the purpose of
        auditing, valuing the company or any other reasonable purpose.

13.     PROTECTION OF BUSINESS OF COMPANY

        So long as this Agreement continues and until a date twelve (12) months
        following the termination of the Company and its Subsidiaries, or
        following the date on which any Party ceases to be a Party pursuant to a
        Disposal hereunder, pursuant to the terms of this Agreement, the
        Shareholders and any Related Company of a Shareholder must not within
        the Territory:

        (1)     participate, assist or otherwise be involved or concerned,
                directly or indirectly, in any capacity in any business which is
                substantially similar to or competitive with the business of the
                Company; or

        (2)     own or control, directly or indirectly more than 10% of the
                shares or other securities, other than on a passive basis, of a
                corporation or trust any part of whose business is substantially
                similar to or competitive with, the business of the Company.

14.     MARKETING RIGHTS

14.1    Subject to the Licence and Distribution Agreement, as from the Effective
        Date the Company is the exclusive and perpetual distribution agent for
        Party A in the Territory for its Product.

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14.2    If for any reason the Product is being distributed in the Territory by
        Party A or any licensee of Party A other than through the Company or its
        Related Company, the Company shall be entitled to receive the royalty or
        benefits out of such distribution received by Party A. Nothing herein is
        intended to limit any other remedy available to the Company under this
        Agreement, the License and Distribution Agreement or applicable law.

14.3    During the Term of this Agreement, Party A agrees to negotiate in good
        faith any offers by the Company or its sublicensees to enter into an
        agreement granting the Company or such sublicensee a license to
        distribute the Products in jurisdictions outside the Territory where the
        Company or such sublicensee would pay Party A commercially reasonable
        royalties for such distribution rights.

15.     MANUFACTURING, MARKETING AND DISTRIBUTION OF PRODUCTS; PATENT
        REGISTRATION

15.1    On or before the Effective Date Party A and the Company must enter into
        the Licence and Distribution Agreement in respect of the PharmaPrint(TM)
        Process technology and Product in the form of the agreement in Annexure
        B.

15.2    At the Company's expense and at the direction of the Board, Party A
        shall apply to register in each jurisdiction in the Territory any and
        all patents held or applied for by Party A in the United States, which
        registrations and applications therefore shall constitute Patented
        Technology as defined in the License and Distribution Agreement. Party A
        shall provide reasonable assistance to achieve the registration of such
        patents in the Territory, including, without limitation, the execution
        of any documents necessary to accomplish the intent stated in this
        clause 15.2. Upon registration, such patents shall be assigned to the
        Company pursuant to the terms of the License and Distribution Agreement.

CONDUCT OF BUSINESS OF COMPANY

16.     MANAGERS

16.1    The Board must appoint a chief executive officer who shall be a member
        of the Board pursuant to clause 22.1.

16.2    The chief executive officer:

        (1)     is responsible for the day-to-day business of the Company
                subject to the overriding control of the Board;

        (2)     is responsible for the preparation and execution of the Annual
                Program, and for the preparation and timely distribution of
                monthly financial statements, quarterly forecasts, profit and
                loss statements and statutory accounts; and

        (3)     recommends to the Board for their approval key staff
                replacements or increases.

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16.3    The Board will appoint an initial chief executive officer, at the
        recommendation from Party B, at the first meeting of the Board held by
        the Initial Directors.

17.     FUNCTIONS OF THE BOARD

17.1    The Board is responsible for the overall direction and control of the
        management of the Company, the prudent development of the external
        public image of the company including all public statements and
        announcements and the formulation of the policies to be applied in the
        conduct of the Company's business.

17.2    The Board must:

        (1)     appoint the CEO of the Company;

        (2)     review and adopt the Annual Program; and

        (3)     review and approve the monthly financial statements, marketing
                reports and other reports of the managers.

17.3    The Board must not assume any obligations or liabilities on behalf of
        the Shareholders except as provided by this Agreement.

18.     MEETINGS OF SHAREHOLDERS

18.1    Meeting of Shareholders are conducted in accordance with the
        Constitution, except as otherwise provided in this clause 18.

18.2    A quorum at the meeting of Shareholders shall be two (2) and shall
        consist of a Party A Shareholder and a Party B Shareholder.

18.3    At any meeting of Shareholders:

        (1)     Party A will exercise 30% of the total votes; and

        (2)     Party B will exercise 70% of the total votes.

19.     PROTECTION OF SHAREHOLDERS

19.1    The Shareholders must exercise their powers in relation to the Company
        to ensure that:

        (1)     the Company carries on and conducts its business and affairs in
                a proper and efficient manner and for its own benefit;

        (2)     the Company transacts all its business on arm's length
                commercial terms;

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        (3)     the Company maintains with a reputable insurer adequate
                insurance against all risks usually insured against by companies
                carrying on the same or a similar business and for the full
                replacement or reinstatement value of all its assets of an
                insurable nature;

        (4)     the Company keeps books of account and makes true and complete
                entries of all its dealings and transactions of and in relation
                to its business;

        (5)     the Company provides each Shareholder within 2 weeks after the
                end of each calendar month with unaudited management accounts
                for the preceding month in a form reasonably acceptable to the
                Shareholders;

        (6)     the Company prepares its accounts on an historical cost basis
                and adopts accounting policies which are either consistent with
                international accounting standards or those generally accepted
                in Hong Kong and agreed between the Shareholders;

        (7)     the Company prepares accounts in respect of each financial year
                which are required by statute and, if required by statute,
                procures that such accounts are audited as soon as practicable
                and in any event not later than 3 months after the end of the
                relevant financial year;

        (8)     cheques drawn on bank accounts of the Company in excess of
                HK$250,000 require the signatures of both a Party A Director and
                a Party B Director;

        (9)     the Company keeps each Shareholder fully informed as to all its
                financial and business affairs; and

        (10)    if the Company requires any material approval, consent or
                licence to carry on its business, the Company uses its best
                endeavors to obtain and maintain them.

20.     SHAREHOLDERS NOT TO INTERFERE

20.1    Subject to clause 20.2 no Shareholder may interfere with the management
        or operations of the Company and without limiting the ambit of this
        prohibition, no Shareholder has the authority to give directions to any
        officers or employees of the Company.

20.2    Nothing in clause 20.1 restricts a Shareholder's ability:

        (1)     to appoint a person to the Board or to influence the way that
                Director votes at a meeting of the Board;

        (2)     to grant or withhold the Shareholder's approval; or

        (3)     to vote at a meeting of Shareholders.

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PARTICULAR POLICIES

21.     DISTRIBUTION POLICY

21.1    If in respect of any calendar quarter the Company has after tax profits
        available for distribution, the Directors must procure that, subject
        only to the prudent financial requirements of the Company (including,
        without limitation, the reinvestment of profits to further develop the
        Company's business), the Company use such profits in the following
        order:

        (1)     set off against any accumulated loss brought forward; and

        (2)     make maximum distributions by way of Dividend or other means as
                agreed, provided always that not more than the legal
                distributable amount which is allowed under the relevant laws
                and regulations and after setting off or repayment under
                paragraph (1) of this clause shall be distributed.

21.2    In deciding whether in respect of any calendar quarter the Company has
        profits available for distribution, any Shareholder may procure the
        Auditors, if any, to certify the profits available. In giving their
        certificate the Auditors act as experts and not arbitrators and their
        determination is binding on the Shareholders.

MEETINGS OF DIRECTORS - CRUCIAL DECISIONS

22.     DIRECTORS

22.1    The board of directors of the Company shall consist of eight (8)
        directors, provided if Benjamin Wei is not a director, the board shall
        consist of seven (7) directors. Party A shall be entitled to designate
        two (2) such directors to the Company and Party B shall be entitled to
        designate five (5) such directors, one whom will be the chief executive
        officer of the Company. The eighth director shall be Benjamin Wei unless
        Party A and Party B agree to the contrary. The Directors shall be
        appointed and removed in accordance with the Constitution; provided,
        however, that Mr. Wei may be removed from the Board at any time as
        agreed by Party A and Party B through their respective directors. Each
        of the Parties agrees to cause its designated directors on the Company
        Board to act in accordance with the Business Plan.

22.2    The Initial Directors are:

        (1)     Benjamin Wei;

        (2)     appointed by Party A: Steven Bowman and Bill Clark; and

        (3)     appointed by Party B: William Lam, Richard Yin, Edmond Wong,
                Hardy Chan and a fifth director that will be designated by Party
                B on a later date.

22.3    Despite the provisions of the Constitution:

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        (1)     no Party A Director can be appointed without the approval of
                both parties (which such approval shall not be unreasonably
                withheld or delayed); and

        (2)     a Party A Director may not be removed without the approval of
                Party A and a Party B may not be removed without the approval of
                Party B.

22.4    Approval may not be unreasonably withheld under clause 22.3 if:

        (1)     the proposed Director is of a caliber and with qualifications
                similar to the Director being replaced or a person continuing as
                a Director; and

        (2)     the Board will continue to be comprised of at least two (2)
                Directors appointed by Party A and five (5) Directors appointed
                by Party B.

22.5    Each Shareholder must ensure that any Director appointed by it is
        familiar with and observes the terms of this Agreement.

22.6    The provisions of clause 22.4 and clause 22.5 apply to any alternate
        director.

23.     MEETINGS OF THE DIRECTORS

23.1    The Directors must meet monthly or at other times as the Directors
        determine.

23.2    The Directors may agree to meet on conference call if it is not possible
        to meet otherwise.

23.3    Not less than 10 days' notice of meetings of Directors must be given to
        all Directors unless all Directors consent to a shorter period. Notice
        may be delivered personally or be given by post, telephone, facsimile or
        e-mail.

23.4    An agenda of items of business to be dealt with at the Directors'
        meeting must be given to each Director at least 5 days before the time
        of the meeting, unless all Directors consent to a shorter period.

23.5    Where the agenda includes any item referred to in clause 25.1, a copy of
        the agenda must also be given to each Shareholder at the same time as it
        is distributed to Directors.

23.6    The agenda may be delivered personally or given by post, telephone,
        facsimile or e-mail.

23.7    A quorum at a meeting of Directors shall be two (2), which shall consist
        of at least one (1) Party A Director and one (1) Party B Director.

23.8    Each Director may exercise one (1) vote at a meeting of Directors.
        However, if only one (1) Party A Director is present at any meeting of
        Directors, that Party A Director may exercise two (2) votes, and if
        fewer than five (5) Party B Directors are present at any

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        meeting of Directors, the Party B Directors present may between them
        exercise five (5) votes.

23.9    Each Shareholder may appoint observers who have the right to be present
        at meetings of the Board. At the invitation of the Board, the observers
        may speak on any matter being considered by the Board but are not
        entitled to vote.

23.10   Copies of the minutes of Board meetings must be delivered to each
        Director within a reasonable time after the completion of the meeting to
        which the minutes relate.

24.     CHAIR OF THE BOARD OF DIRECTORS

24.1    The Directors will elect one of their number as the chair of the Board
        from time to time.

24.2    The chair of the Board will not have any casting or additional vote.

25.     MATTERS REQUIRING UNANIMOUS DIRECTORS' APPROVAL

25.1    The Shareholders must exercise their powers in relation to the Company
        to ensure that except with the prior approval of a resolution of the
        Directors passed unanimously by all Directors present and voting
        representing Party A and Party B, respectively, the Company does not:

        (1)     CONTRACTS WITH DIRECTORS OR SHAREHOLDERS

                enter into, vary or terminate any contract or arrangement
                (whether legally binding or not) with any of its Directors or
                any Shareholder or with any Related Company of a Shareholder;

        (2)     CONTRACTS OUTSIDE ORDINARY COURSE OF BUSINESS

                enter into any material contract or arrangement outside the
                ordinary course of its business or by which any person would or
                might receive remuneration calculated by reference to Company
                income or profits;

        (3)     MAJOR ASSETS

                acquire or dispose of any asset (or several assets pursuant to a
                single contract) at a purchase or sale price of greater than
                US$500,000;

        (4)     EMPLOYMENT AND DIRECTORS' CONTRACTS

                vary the terms of service (including compensation, remuneration
                and emoluments) of a Director or senior employee (meaning an
                employee whose rate of gross contractual salary is HK$2,000,000
                per annum or more) of the Company or, in the latter case,
                appoint or dismiss the employee;

<PAGE>   17

        (5)     AUDITOR

                appoint or remove the auditor to the Company;

        (6)     EMPLOYEE SCHEMES

                enter into any non-statutory death, retirement, life or medical
                insurance, profit sharing, bonus, share option or other scheme
                for the benefit of the officers or employees of the Company
                whose terms materially differ from the terms of such schemes
                typically offered by similar companies in the industry;

        (7)     DISTRIBUTIONS

                pay or make any Dividend or other distribution including make
                any distribution out of capital profits or capital reserves
                except under clause 21;

        (8)     SUBSIDIARIES AND INVESTMENTS

                acquire or make any investment in another company or business or
                incorporate any Subsidiary (other than as contemplated by this
                Agreement and any of the Operative Agreements);

        (9)     CHANGE IN BUSINESS

                change the nature or scope of its business as carried on for the
                time being to a material extent (including cessation) or
                commence any new business not being ancillary or incidental to
                such business;

        (10)    PARTNERSHIPS ETC.

                enter into any partnership or joint venture with any other
                person or merge or amalgamate with any person (other than as
                contemplated by this Agreement and any of the Operative
                Agreements);

        (11)    EARLY REPAYMENTS

                make any early repayment of any of its indebtedness;

        (12)    ANNUAL PROGRAM

                adopt the Annual Program or depart from the Annual Program in
                any manner reasonably considered significant by any Shareholder;

        (13)    CHIEF EXECUTIVE OFFICER

<PAGE>   18

                appoint or remove the chief executive officer;

        (14)    CHANGE IN COMPOSITION OF BOARD

                increase or decrease the total number of Directors or vary the
                proportion of Party A Directors to Party B Directors;

        (15)    ISSUANCE OF SECURITIES

                issue any equity securities or similar interests of the Company

DEADLOCK

26.     DEADLOCK

26.1    If a matter is submitted to a meeting of the Board for decision under
        clauses 25 and the Board meeting is unable to reach a decision, the
        matter must be referred to the chief executive officers of each of the
        Shareholders' ultimate Holding Company (or of the Shareholder if it has
        no Holding Company) and failing agreement by them within 14 days to the
        boards of directors of those Holding Companies (and of a Shareholder
        which has no Holding Company). If the boards of directors of the Holding
        Companies (and of a Shareholder which has no Holding Company) fail to
        agree on the matter within a further period of 30 days a deadlock must
        be treated as having occurred in relation to that matter.

26.2    Within 14 days after the deadlock arises a Shareholder ("Offeror") may
        make an unconditional offer in writing ("Bid Notice") to sell all its
        Shares to the other Shareholder ("Recipient") at the price specified in
        the Bid Notice.

26.3    Within 14 days after service of the Bid Notice ("Bid Notice Period") the
        Recipient must elect either to accept or reject the offer made by the
        Offeror.

26.4    If the Recipient rejects or fails to accept the offer made by the
        Offeror within the Bid Notice Period the Recipient must sell and the
        Offeror must buy the Shares held by the Recipient unconditionally and at
        the same price per Share specified in the Bid Notice.

26.5    Completion of the transfer of Shares must take place on or before the
        14th day after the expiration of the Bid Notice Period and after all
        necessary consents and approvals have been obtained. At the time of
        completion of the transfer the selling party must hand to the purchasing
        party transfers of the selling party's Shares executed by the selling
        party together with the certificates for those Shares and the purchasing
        party must simultaneously hand to the selling party a bank cheque for
        the total purchase price.

DISPOSAL OF SHARES

27.     DISPOSAL OF SHARES

<PAGE>   19

27.1    The restrictions in this clause 27 apply in addition to the restrictions
        contained in the Constitution.

27.2    A Shareholder must not Dispose of any of its Shares or Loans (or any
        interest in either) except:

        (1)     by a transfer of its entire undivided legal and beneficial
                interest in the Shares and Loans Disposed of; or

        (2)     in open market transactions after the listing of the Shares on a
                public exchange or electronic trading system in any
                jurisdiction; or

        (3)     to a Related Company of the Shareholder.

27.3    The proposed transferee must either:

        (1)     acquire all the Shares and all the Loans of a Shareholder; or

        (2)     acquire with Shares of the Shareholder that part of the Loans of
                the Shareholder which is in the same proportion to the total
                Loans of the Shareholder as the Shares acquired are to the total
                Shares of the Shareholder.

27.4    The Shareholders must ensure that before any person (other than a
        Shareholder) is registered as a holder of any Share, whether by
        allotment or transfer, that person enters into a deed in a form agreed
        by the Shareholders by which that person agrees to be bound by the terms
        of this Agreement. The Shareholders must ensure that the Company does
        not register that person as the holder of any Share until the deed has
        been executed. Upon being registered that person must be treated as a
        Party to this Agreement.

27.5    The Shareholders must ensure that the Company does not register any
        transfer made in breach of this clause 27 and that the Shares comprised
        in any transfer so made carry no rights until the breach is rectified.

28.     TRANSFER OF SHARES

28.1    A Shareholder wishing to dispose of its Shares ("Transferring
        Shareholder") must first offer its Shares ("Offered Shares") in writing
        for cash to the other Shareholders specifying the price payable for the
        Shares ("Offer Price") and the terms and conditions of the offer. The
        Shareholder receiving the offer must accept or reject the offer within a
        period of 60 days after receipt of the offer by giving notice of its
        acceptance or rejection of the offer to the Transferring Shareholder. If
        the offer is not accepted or rejected within 60 days it must be treated
        as rejected at the expiry of that time. If the offer is rejected, then
        the Transferring Shareholder is entitled, within a further period of 60
        days following the rejection, to sell the Offered Shares to a third
        person on the same terms and conditions and at a price which must be in
        cash and not lower than the Offer Price but the right to sell is subject
        to compliance with the conditions in clause 27.

<PAGE>   20

DEFAULT

29.     MATERIAL BREACH

29.1    In this clause 29 "Material Breach" means any breach of either this
        Agreement (including a breach of the warranties in clause 31) or of the
        Constitution which is material having regard to all relevant
        circumstances including the nature of the relationship between the
        Shareholders and the need for each Shareholder to maintain the
        confidence of the other, the nature of the breach (and in particular
        whether it is intentional, negligent or otherwise) and the consequences
        of the breach.

29.2    If at any time a Shareholder ("Defaulting Shareholder") commits a
        Material Breach, any Shareholder ("Aggrieved Shareholder") may serve
        notice ("Material Breach Notice") on the Defaulting Shareholder
        identifying the relevant Material Breach and referring to this clause
        29.2. A Material Breach Notice must be served within 60 days after the
        Aggrieved Shareholder becomes aware of the relevant Material Breach.

29.3    For the purposes of clause 29.6 a "Relevant Event" occurs if:

        (1)     the Defaulting Shareholder commits a Material Breach;

        (2)     the Aggrieved Shareholder serves a Material Breach Notice; and

        (3)     30 days has elapsed since the Material Breach Notice was served
                and either:

                (a)     the Material Breach has not been remedied; or

                (b)     the Material Breach is not capable of being remedied;

        except that if:

        (4)     the Defaulting Shareholder claims that there has not been a
                Material Breach;

        (5)     the Aggrieved Shareholder agrees to the claim being referred to
                a named expert; and

        (6)     the Defaulting Shareholder refers the claim to the expert within
                the 30 day period;

        a Relevant Event does not occur unless and until the expert determines
        that a court of competent jurisdiction would on the balance of
        probabilities hold that there was a Material Breach.

29.4    The expert's fees are payable by the Defaulting Shareholder if the
        expert advises that a court of competent jurisdiction would on the
        balance of probabilities hold that the relevant Material Breach Notice
        was valid and otherwise by the other Shareholders.

<PAGE>   21

29.5    If the expert advises that a court of competent jurisdiction would on
        the balance of probabilities hold that the relevant Material Breach
        Notice was valid, then it must be treated as valid for all purposes. If
        the expert advises otherwise then the relevant Material Breach Notice
        must be treated as void.

29.6    If a Relevant Event occurs, then:

        (1)     any shareholder may purchase the Defaulting Shareholder's shares
                at a price per share determined:

                (a)     by agreement between the Shareholders; or

                (b)     if no agreement is reached between the Shareholders
                        within 14 days from the date of the Relevant Event, by
                        an independent valuer appointed by a unanimous
                        resolution of the Board; or

                (c)     if no valuer is appointed by the Board within 30 days
                        from the date of the Relevant Event, by the Chief
                        Executive of the Hong Kong Society of Accountants or his
                        nominee; or

        (2)     if the Shares of the Defaulting Party are not purchased by
                another Shareholder within the later of 60 days from the date of
                the Relevant Event and the valuation determined pursuant to
                clause 29.6(1)(b) or 29.6(1)(c), any Shareholder other than the
                Defaulting Party is entitled to apply to have the Company wound
                up. The right to apply to have the Company wound up shall expire
                30 days after such right commences.

WINDING UP OF COMPANY

30.     RIGHTS ON WINDING UP OF COMPANY

30.1    On the winding up of the Company:

        (1)     any business name of the Company must be deregistered;

        (2)     the Company must surrender the licence of any intellectual
                property licensed to it by any Shareholder;

        (3)     any other arrangements between the Company and Shareholders in
                relation to the business and assets of the Company terminate;

        (4)     each Shareholder must cease as soon as practicable to make any
                reference to the other Shareholders (or any Related Company of
                any other Shareholder) in any material or advertising published
                by it in connection with its business; and

<PAGE>   22

        (5)     the Shareholders are entitled to have full access to the clients
                and customers of the Company.

        (6)     Neither Shareholder will set up business in direct competition
                to the other Shareholder during the Joint Venture or within 12
                months of winding up the Joint Venture; provided, however, that
                the non-Defaulting Party shall have the right to continue the
                business of the Company.

ANCILLARY PROVISIONS

31.     WARRANTIES

31.1    Each of the Parties represents and warrants to each other Party that it
        is a company duly incorporated and validly existing under the laws of
        the country of its incorporation and has all requisite powers to own
        property and has the necessary power to bind itself in the manner
        contemplated by this Agreement and to execute, deliver and perform this
        Agreement.

31.2    Each of the Parties represents and warrants to each other Party that it
        has performed all corporate actions and received all corporate
        authorizations necessary to execute and deliver this Agreement and to
        perform its obligations hereunder.

31.3    Each of the Parties represents and warrants to each other Party that
        this Agreement has been validly executed and delivered by it and
        constitutes the valid, binding and enforceable obligations of it in
        accordance with its terms.

31.4    Each of the Parties represents and warrants to each other Party that it
        has and shall maintain the power and authority and all material
        governmental licenses, authorizations, consents and approvals to be
        obtained within its jurisdiction of formation and principal place of
        business to own its assets, carry on its business and to execute,
        deliver, and perform its obligations under this Agreement.

31.5    Each of the Parties represents and warrants to each other Party that
        there are no (A) non-governmental third parties and (B) governmental or
        regulatory entities in its jurisdiction of formation and principal place
        of business who are entitled to any notice of the transaction, licenses
        and services contemplated hereunder or whose consent is required to be
        obtained by such Party for the consummation of the transaction
        contemplated hereunder.

31.6    Party A acknowledges that Party B has entered into this Agreement in
        reliance upon Party A's contribution of its intellectual property
        related to the Product (including, without limitation, the Patented
        Technology and Licensed Marks, as those terms are defined in the License
        and Distribution Agreement). Party A hereby confirms its representation
        and warranties in clauses 12.1(f) and (g) of the License and
        Distribution Agreement, which are incorporated herein by reference.

<PAGE>   23

31.7    Except as set forth in Item 9 of the schedule, each of the Parties
        represents and warrants to each other Party that no Person is or will be
        entitled to any broker's or finder's fee, or any other commission or
        similar fee in connection with any of the transactions contemplated
        hereby as a result of any action taken by or on behalf of such Party.

32.     THE CONSTITUTION

32.1    The Shareholders agree that the provisions of this Agreement override
        the provisions of the Constitution if there is any inconsistency.

32.2    Each Shareholder undertakes with each other Shareholder to:

        (1)     exercise all votes, powers and rights under the Constitution to
                give effect to the provisions and intentions of this Agreement;
                and

        (2)     observe and comply promptly with the provisions of the
                Constitution.

32.3    Nothing contained in this Agreement constitutes an amendment of the
        Constitution.

32.4    If any provision of this Agreement to be effective needs to be included
        in the Constitution, the Shareholders must amend the Constitution
        accordingly.

33.     CONFIDENTIAL INFORMATION

33.1    In this clause unless the context otherwise requires:

        (1)     "Approved Purposes" means the purposes of the Company and the
                joint venture;

        (2)     "Confidential Information" means information of every kind:

                (a)     concerning or in any way connected with:

                        (i)     the joint venture;

                        (ii)    the subject matter of the joint venture;

                        (iii)   the Company;

                        (iv)    any Related Company of the Company;

                        (v)     the Supplying Party; or

                        (vi)    any Related Company of the Supplying Party; or

                (b)     which is the property of the Company or of the Supplying
                        Party or any Related Company of the Company or of the
                        Supplying Party;

<PAGE>   24

                and which:

                (c)     is disclosed in writing, orally or by any other means by
                        the Supplying Party to the Receiving Party or by any
                        person on behalf of the Supplying Party to the Receiving
                        Party or an employee, officer or agent of the Receiving
                        Party; or

                (d)     comes to the knowledge of the Receiving Party or an
                        employee, officer or agent of the Receiving Party by any
                        means;

        (3)     "Notes" means notes which relate to, summaries and copies of and
                extracts from any Confidential Information whether in
                documentary, visual, machine readable or other form;

        (4)     "Receiving Party" means a Shareholder or the Company which
                receives Confidential Information; and

        (5)     "Supplying Party" means a person (including a Party to this
                Agreement and the Company) by which Confidential Information is
                supplied to the Receiving Party.

33.2    The Receiving Party must:

        (1)     maintain and take all steps necessary to maintain all
                Confidential Information and all Notes in strictest confidence;

        (2)     ensure that proper and secure storage is provided for the
                Confidential Information and all Notes while in the possession
                or under the control of the Receiving Party;

        (3)     take all precautions necessary to prevent accidental disclosure
                of any of the Confidential Information or any of the Notes;

        (4)     not disclose any of the Confidential Information or Notes to any
                person other than those of the Receiving Party's employees,
                officers and agents who are required to receive and consider the
                Confidential Information in the course of (and solely for) the
                Approved Purposes;

        (5)     use Confidential Information and Notes solely for the Approved
                Purposes;

        (6)     not make Notes or allow Notes to be made except as necessary in
                connection with the Approved Purposes;

        (7)     keep a record of what copies have been made of Confidential
                Information and of Notes and what Notes have been made and by
                whom and supply this information to the Supplying Party on
                request;

<PAGE>   25

        (8)     keep confidential the fact that Confidential Information has
                been provided by the Supplying Party to the Receiving Party; and

        (9)     not expressly or impliedly disclose the existence of
                Confidential Information or Notes.

33.3    Clause 33.2 does not impose obligations on the Receiving Party
        concerning Confidential Information which the Receiving Party proves to
        the reasonable satisfaction of the Supplying Party:

        (1)     at the date of this Agreement is publicly available;

        (2)     subsequent to the date of this Agreement becomes publicly
                available without breach of this Agreement;

        (3)     the Receiving Party obtained from a third party without breach
                by that third party of any obligation of confidence concerning
                that Confidential Information; or

        (4)     was already in the Receiving Party's possession (as evidenced by
                written records) when provided by or on behalf of the Supplying
                Party.

33.4    It is not a breach of clause 33.2 for the Receiving Party to disclose
        Confidential Information which it is obliged by law to disclose to the
        person to whom it is disclosed or to the general public, if necessary or
        disclosure of Confidential Information in the ordinary course of a
        party's business provided such Confidential Information is not
        proprietary.

33.5    The Receiving Party must use its best endeavors to cause all of its
        employees, officers and agents who receive or have access to
        Confidential Information or Notes to observe all of the Receiving
        Party's obligations and undertakings contained in this clause 33.

33.6    The Receiving Party must return all documents and other media which
        contain Confidential Information and deliver all Notes to the Supplying
        Party:

        (1)     immediately when requested by the Supplying Party to do so;

        (2)     when the Receiving Party ceases to be a Shareholder;

        (3)     when the Company goes into liquidation; or

        (4)     when the joint venture terminates;

        whichever is the earliest.

<PAGE>   26

33.7    The Receiving Party's obligations and undertakings continue indefinitely
        and are not diminished or terminated by the completion or termination
        for any reason of this Agreement.

33.8    The Parties must ensure that the Company complies with obligations so
        far as is possible identical with those obligations placed upon them by
        this clause 33.

34.     PUBLIC STATEMENTS

34.1    Except as required by law, court order or public relation purpose
        neither Shareholder may issue any statement, confirm, or otherwise
        release information to or through any medium for the communication of
        information to the public, except with the prior concurrence of the
        other Shareholder both as to the content and timing of the release:

        (1)     concerning the business or affairs of the Company; or

        (2)     that this Agreement exists.

35.     GOOD FAITH

35.1    Each Shareholder must:

(1)     give all co-operation and assistance reasonably necessary to make the
        operations of the Company successful;

(2)     do all things reasonably within its power which are necessary or
        desirable to give effect to the spirit and intent of this Agreement and
        the Constitution; and

(3)     be just and faithful to each other Shareholder.

35.2    No Shareholder may pledge the credit of any other Shareholder.

36.     TIME OF THE ESSENCE

36.1    Time is of the essence of this Agreement.

37.     NO PARTNERSHIP ETC.

37.1    This Agreement does not create or evidence a partnership or a fiduciary
        relationship or the relationship of principal and agent between the
        Parties.

37.2    Except as specifically provided in this Agreement no Shareholder may or
        has authority to act as agent or representative of or in any way bind or
        commit another Shareholder to any obligation.

38.     MEDIATION

<PAGE>   27

38.1    If a dispute arises in connection with this Agreement, a Party to the
        dispute must give to the other Party notice specifying the dispute and
        requiring its resolution under this clause 38 ("Notice of Dispute").

38.2    If the dispute is not resolved within 30 days after the Notice of
        Dispute is given to the other Party ("Notice Period"), the dispute is by
        this clause submitted to mediation. The mediation must be conducted in
        Hong Kong.

38.3    If the Parties have not agreed upon the mediator and the mediator's
        remuneration within 7 days after the Notice Period:

        (1)     the mediator is the person appointed by; and

        (2)     the remuneration of the mediator is the amount or rate
                determined by;

        the President of the Law Society of Hong Kong ("President") or the
        President's nominee, acting on the request of any Party.

38.4    If the dispute is not resolved within 28 days after the appointment of
        the mediator any Party may submit the dispute to arbitration pursuant to
        clause 46.

38.5    This clause 38 does not prevent any Party from obtaining any injunctive,
        declaratory or other interlocutory relief from a court which may be
        urgently required.

39.     SEVERABILITY

        If anything in this Agreement is unenforceable, illegal or void then it
        is severed and the rest of this Agreement remains in force.

40.     ENTIRE UNDERSTANDING

40.1    This Agreement, the Operative Agreements and the Constitution:

        (1)     are the entire agreement and understanding between the Parties
                on everything connected with the subject matter of this
                Agreement; and

        (2)     supersede any prior agreement or understanding on anything
                connected with that subject matter.

40.2    Each Party has entered into this Agreement without relying on any
        representation by any other Party or any person purporting to represent
        that Party.

41.     VARIATION

        An amendment or variation to this Agreement is not effective unless it
        is in writing and signed by the Parties.

<PAGE>   28

42.     WAIVER

42.1    A Party's failure or delay to exercise a power or right does not operate
        as a waiver of that power or right.

42.2    The exercise of a power or right does not preclude either its exercise
        in the future or the exercise of any other power or right.

42.3    A waiver is not effective unless it is in writing.

42.4    Waiver of a power or right is effective only in respect of the specific
        instance to which it relates and for the specific purpose for which it
        is given.

43.     FURTHER ASSURANCE

        Each Party must promptly at its own cost do all things (including
        executing all documents) necessary or desirable to give full effect to
        this Agreement.

44.     COSTS

        Each Party must pay its own costs and disbursements connected with the
        negotiation, preparation and execution of this Agreement and the
        Operative Agreements.

45.     NOTICES

        Any notice required or permitted to be given hereunder shall be in
        writing and shall be (a) personally delivered, (b) transmitted by
        internationally recognized air courier service, or (c) transmitted by
        facsimile, in each case to the parties as follows, as elected by the
        party giving such notice, to the other parties at the addresses set
        forth on Schedule 1 of this Agreement, or as amended by notice pursuant
        to this subsection. Except as otherwise specified herein, all notices
        and other communications shall be deemed to have been duly given on (i)
        the date of receipt if delivered personally, (ii) three (3) Business
        Days after delivery to the courier, or (iii) the next Business Day in
        the jurisdiction of the recipient following the date of transmission
        with electronic confirmation if transmitted by facsimile, whichever
        shall first occur. Any party may change its address for purposes hereof
        by notice to the other parties. All notices and other communications
        shall be in the English language.

46.     GOVERNING LAW AND JURISDICTION; ARBITRATION

46.1    This Agreement shall be governed and interpreted in accordance with the
        Laws of Hong Kong Special Administrative Region.

<PAGE>   29

46.2    Subject to clause 38 hereof, the Parties agree to submit all disputes
        arising out of this Agreement to arbitration in Hong Kong in accordance
        with the Model Law on International Commercial Arbitration adopted by
        the United Nations Commission on International Trade Law.

47.     STRUCTURAL CHANGE, BANKRUPTCY

        If there is any bankruptcy or similar filing or proceeding against Party
        A, Party B shall have the right to purchase Party A's equity interest in
        the Company at a cash purchase price equal to the fair market value of
        the Company as of the date such filing or proceeding was instituted.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

<PAGE>   30

                                   SCHEDULE 1

Item 1  COMMENCEMENT DATE [CLAUSE 1.1(7)]

        The date of this Agreement is August 31, 2000

Item 2  EFFECTIVE DATE [CLAUSE 1.1(13)]

        [ ] 2000

Item 3  NUMBER OF SHARES FOR WHICH PARTY A MUST SUBSCRIBE [CLAUSE 5.1]

        300,000 shares

Item 4  NUMBER OF SHARES FOR WHICH PARTY B MUST SUBSCRIBE [CLAUSE 5.2]

        700,000 shares

Item 5  AMOUNT OF AUTHORISED AND PAID UP CAPITAL AFTER THE EFFECTIVE DATE
        [CLAUSE 5.3]

        Authorised capital: 5,000,000 shares with no par value
        Paid up capital:    1,000,000 shares of US$500,000 in total

Item 6  TERRITORY [CLAUSE 1.1(25)]

        All countries within Asia Pacific including but not limited to Hong
        Kong, The People's Republic of China, North and South Korea, Japan,
        Singapore, Taiwan, Macau, Indonesia, Malaysia, Thailand, Vietnam, The
        Philippines, India, Pakistan, Brunei, Bangladesh, Sri Lanka, Papua New
        Guinea and Myanmar, Australia and New Zealand and any other city,
        province or country agreed to in writing by the Parties.

Item 7  PARTY A'S ADDRESS FOR SERVICE AND FACSIMILE NUMBER [CLAUSE 45]

        Name         :    PharmaPrint Inc.
        Attention    :    Chief Executive Officer
        Address      :    4701 Von Karman Avenue, Suite 201, Newport Beach,
                          California 92660, United States of America
        Facsimile No.:    949-794-7777

Item 8  PARTY B'S ADDRESS FOR SERVICE AND FACSIMILE NUMBER [CLAUSE 45]

        Name         :    Capital Alert Investments Ltd
        Attention    :    Richard Yin
        Address      :    c/o 5/F., Hutchison House, 10 Harcourt Road

<PAGE>   31

                          Central, Hong Kong
        Facsimile No.:    (852) 2845 3368

Item 9  BROKER'S OR FINDER'S FEE [CLAUSE 31.7]

        Upon closing, First Consulting Group, Inc. shall receive from Party A a
        fee equal to 7% of the advanced by Party A pursuant to Clause 5.1
        proceeds and options to purchase up to 500,000 shares of Party A's
        common stock over three years at an option price of $0.375. Neither
        Party B nor the Company shall incur any obligation to First Consulting
        Group, Inc. as a result of the fees described herein.

                            [SIGNATURE PAGE FOLLOWS]

<PAGE>   32

EXECUTED as an agreement.

                                      PHARMAPRINT INC.

                                      By:
                                          -----------------------------------
                                          Name: Steven A. Bowman
                                          Its: Chief Executive Officer

                                      CAPITAL ALERT INVESTMENT LTD

                                      By:
                                          -----------------------------------
                                          Name:
                                          Its:

<PAGE>   33

                                   ANNEXURE A

                           Constitution of the Company

                                 [clause 1.1(9)]

The name of the Company is "Kingsway PharmaPrint Asia Limited" or such other
name determined by the Parties.

Item 1  The Registered Office of the Company will be situated at P.O. box 957,
        Offshore Incorporations Center, Road Town, Tortilla, British Virgin
        Islands.

Item 2  The Liability of the Members is limited.

Item 3  The Authorised Share Capital of the Company is 5,000,000 shares with
        no par value with the power for the Company to increase or reduce the
        said capital and to issue any part of its capital, original or
        increased, with or without preference, priority or special privileges,
        or subject to any postponement of rights or to any conditions or
        restrictions and so that, unless the conditions of issue shall otherwise
        expressly declare, every issue of shares, whether declared to be
        preference or otherwise, shall be subject to the power hereinbefore
        contained.

Item 4  The Company shall be a private company and accordingly the following
        provisions shall have effect:

        (a)     The number of Members for the time being of the Company
                (exclusive of persons who are in the employment of the Company,
                and of persons, who having been formerly in the employment of
                the Company were, while in such employment and having continued
                after the determination of such employment to be, Members of the
                Company) is not to exceed fifty, but where two or more persons
                hold one or more shares in the Company jointly, they shall, for
                the purpose of the paragraph, be treated as a single Member.

        (b)     Any invitation to the public to subscribe for any shares or
                debentures or debenture stock of the Company is hereby
                prohibited.

        (c)     The Company shall not have power to issue share warrants to
                bearer.

<PAGE>   34

                                   ANNEXURE B

                       Dated the 31st day of August, 2000

                                PHARMAPRINT INC.

                                       AND

                        KINGSWAY PHARMAPRINT ASIA LIMITED

                       LICENCE AND DISTRIBUTION AGREEMENT

<PAGE>   35

THIS LICENCE AND DISTRIBUTION AGREEMENT IS MADE THE 31ST DAY OF AUGUST, 2000.

BETWEEN

(1)     PHARMAPRINT INC, a company incorporated under the laws of Delaware,
        United States of America and having its registered office at 4701 Von
        Karman Avenue, Suite 201, Newport Beach, CA 92660, U.S.A. ("Party A");
        and

(2)     KINGSWAY PHARMAPRINT ASIA LIMITED, a company incorporated under the laws
        of the British Virgin Islands and whose registered office is situate at
        P.O. Box 957 Offshore Incorporations Center, Road Town, Tortola, British
        Virgin Islands ("Party B").

WHEREAS:

(A)     Party A is a company that develops, manufactures and markets dietary
        supplements, functional foods and pharmaceuticals derived from natural
        plant extracts. Party A is the proprietary owner of the PharmaPrint(TM)
        Process technology. The PharmaPrint(TM) Process technology enables the
        precise identification and consistent replication of the active
        ingredients from the natural plant extracts that are scientifically
        believed to provide the desired health benefits.

(B)     Party A has entered into a joint venture shareholders' agreement with
        Capital Alert Investments Limited, a company incorporated under the laws
        of the British Virgin Islands on August 31, 2000 for the formation and
        operation of Party B.

(C)     Party A has agreed to grant to Party B a licence for the manufacturing,
        marketing and distribution of the Product in the Asia Pacific Region as
        set forth herein.

NOW IT IS AGREED between the parties as follows:

1.      DEFINITIONS

1.1     In this Agreement, unless the context otherwise requires, the following
        expressions shall have the following meanings:

        "Asia Pacific Region" are countries within Asia Pacific, including but
        not limited to, Hong Kong, The People's Republic of China, North and
        South Korea, Japan, Singapore, Taiwan, Macau, Indonesia, Malaysia,
        Thailand, Vietnam, The Philippines, India, Pakistan, Brunei, Bangladesh,
        Sri Lanka, Papua New Guinea and Myanmar, Australia and New Zealand.

<PAGE>   36

        "Know-How" means Party A's information and manufacturing directions,
        drawings, processing information, standards and specifications as to the
        materials to be used, control methods and test data necessary to
        manufacture Products.

        "Patented Technology" means the PharmaPrint(TM) Process technology
        itemized on Schedule 1.1 hereto including the modifications and updates
        developed by Party A and its Related Company and as further modified
        pursuant to clause 16.1. Schedule 1.1 may be amended from time to time
        as Party A applies for or is issued additional patents.

        "Product" means the dietary supplements, functional foods and
        pharmaceuticals derived from natural plant extracts produced by Party B
        or any sublicensee, contractor or other third party using the Patented
        Technology.

        "Related Company" in respect of a company means its Subsidiary, its
        Holding Company or another company within the same Group of Companies as
        the first mentioned company (as those terms are defined in Section 2 of
        the Companies Ordinance (cap. 32)).

        "Services" means the provision of access rights, maintenance and usage
        of the Patented Technology to third parties, and training programs.

1.2     In this Agreement, unless the context otherwise requires, words
        importing a gender shall include every gender and words importing the
        singular shall include the plural and vice versa.

1.3     Headings in this Agreement are inserted for convenience only and shall
        be ignored in construing this Agreement.

2.      LICENCE AND DISTRIBUTION AGREEMENT

        2.1 Party A hereby assigns, transfers and sets over to Party B all
        right, title and interest to all patents, registrations and/or
        applications filed by Party A or its agent in any jurisdiction in the
        Asia Pacific Region as set forth on Schedule 1.1 (the "Asia Patents").
        Party A hereby grants Party B a non-exclusive (subject to Section 9),
        perpetual, royalty-free (except pursuant to Section 5) and fully-paid
        license (i) to use, modify, reproduce, display, make, deploy and
        otherwise exploit the Patented Technology, Know-How and the associated
        intellectual property rights therein in the manufacturing of the
        Products, and (ii) to sublicense any of the foregoing rights pursuant to
        Section 14 in any jurisdiction in the Asia Pacific Region (collectively,
        the "Technology License"), each during the term of this Agreement. Party
        A hereby grants Party B an exclusive, perpetual, royalty-free (except
        pursuant to Section 5) and fully-paid license (i) to use the Licensed
        Marks (as defined in Section 10.2) in the Asia Pacific Region and (ii)
        to sublicense any of the foregoing rights pursuant to Section 14 in any
        jurisdiction in the Asia Pacific Region (collectively, the "Trademark
        License"), each during the term of this Agreement. Party A hereby grants
        to Party B an exclusive and perpetual right and license to market,
        promote and distribute ("the Distribution Right") the Product in the
        Asia Pacific Region on the terms and conditions set out below during the
        term of this

<PAGE>   37

        Agreement. Notwithstanding the foregoing, the Technology License,
        Trademark License and Distribution Right granted in this Section 2
        (collectively, the "Licenses") shall not include the right to
        pharmaceutical discovery or development of any Product which would
        require U.S. Food and Drug Administration approval or any similar U.S.
        government approval process prior to their sale. Party B hereby grants
        to Party A a perpetual, royalty free non-exclusive and fully paid
        license to use, modify, reproduce, display, make, deploy and otherwise
        exploit the Asia Patents and to sublicense any of the foregoing rights
        subject to the limits provided for herein, including, without
        limitation, such rights that are granted exclusively to Party B.

3.      PRODUCTS AND SERVICES

3.1     The Licences shall include the right to manufacture, market, promote and
        distribute the Product manufactured by using the Patented Technology in
        the Asia Pacific Region and the right to sublicense the Patented
        Technology and Know-How for the manufacture, marketing, promotion and
        distribution of Products in the Asia Pacific Region.

3.2     For the avoidance of doubt, Party B shall have the unfettered right
        subject to the terms and conditions hereof to lay down the terms and
        conditions for the use of the Patented Technology and Services by
        customers and charge such fees and conditions as Party B may think fit.

4.      CUSTOMIZATION AND LAUNCHING OF SERVICE

4.1     Party B shall have the right to test the Product, by itself or a
        qualified person, before the Launch Date to verify that the Product
        complies with the legal requirements and standards in the Asia Pacific
        Region.

4.2     Party A and Party B shall discuss from time to time the standard of the
        Product and seek ways to improve and upgrade the Product.

4.3     Party A shall use reasonable efforts to make all improvements,
        modifications, enhancements and updates to the Patented Technology and
        Know-How as Party A reasonably considers necessary, but Party B shall
        bear and pay all cost for the customization of such improvements,
        modifications, enhancements and updates for the Asia Pacific Region
        requested by Party B. Party A shall provide an estimated cost prior to
        the customization.

4.4     Party A shall provide operating manuals and training to the extent such
        exist (including update manuals and training) and technical support
        services to Party B and its staff in a timely manner. Party B shall
        reimburse Party A for its reasonable costs and expenses associated with
        providing such training and services, including, without limitation, the
        per diem salary costs of Party A employees providing requested training
        and support services and the reasonable expenses for necessary travel.

5.      ROYALTY

<PAGE>   38

        In consideration of the granting of the Licences, Party B agrees to pay
        a royalty of 5% of the gross sales of Products and 5% of any other
        revenues generated directly or indirectly from the Patented Technology
        or Know-How, less reasonable provisions for bad debts computed in
        accordance with international accounting standards or those generally
        accepted in Hong Kong and agreed between the parties. The royalty is
        payable to Party A within 30 days after the end of each calendar quarter
        (i.e. no later than April 30, July 30, October 30 and January 30).

6.      NAME OF THE PRODUCTS AND SERVICES

        The Product shall be launched under "PharmaPrint" or in such other
        manner as mutually agreed between the parties.

7.      PROMOTION

        Party B will promote the Product in Hong Kong and other countries or
        cities within the Asia Pacific Region as Party B shall deem appropriate
        and as governed by this Agreement.

8.      CUSTOMIZATION FOR OTHER ASIAN MARKETS

        If requested by Party B, Party A shall customize the Product, within a
        time table and costs mutually agreeable to both parties, for other
        countries or cities within the Asia Pacific Region in manner as
        requested by Party B so as to make the Product suitable for market and
        distribution in such countries or cities. Party B shall have the same
        right to promote, market and use all such technology and know-how in the
        same manner as set out above.

9.      EXCLUSIVE AND PERPETUAL RIGHT

9.1     Party B shall have the perpetual, non-exclusive right to use the
        Patented Technology and Know-How to manufacture the Product during the
        term hereof and the exclusive and perpetual right and license to market
        and distribute the Product within the Asia Pacific Region during the
        term hereof as provided in Section 2 hereof.

9.2     Subject to the proviso in Section 2 hereof, Party A shall not, and shall
        not permit any other person except Party B during the license period to:

        (a)     license in connection with the sale or distribution of Product,
                the Patented Technology and Know-How or similar technology and
                know-how to any person or company within the Asia Pacific
                Region, or

        (b)     license in connection with the sale or distribution of Product,
                any person or company to use the Patented Technology and
                Know-How or any similar

<PAGE>   39

                technology and know-how developed by Party A or its Related
                Companies in the Asia Pacific Region, or

        (c)     license in connection with the sale or distribution of Product,
                any person or company to use the Patented Technology and
                Know-How or any similar technology and know-how developed by
                Party A or its Related Companies in a way as to compete with
                Party B's business in the Asia Pacific Region, or

        (d)     market and distribute the Product or similar products in the
                Asia Pacific Region utilizing the Patented Technology and
                Know-How or any similar technology and know-how in a way as to
                compete with Party B's business or license any third party to do
                any of the same.

9.3     Notwithstanding the foregoing, in the event that any third party (a
        "Manufacturing Licensee") will obtain a license to the Patented
        Technology, Know-How or similar technology from Party A or its Related
        Companies for the manufacture of the Products in the Asia Pacific
        Region:

        (a)     Party A shall provide to Party B prompt written notice of
                negotiations with a potential Manufacturing Licensee prior to
                the date that Party A and such Manufacturing Licensee enter into
                a definitive agreement(s);

        (b)     The shares of such Manufacturing Licensee's capital stock must
                be listed on the New York Stock Exchange or on the Nasdaq
                National Market; and

        (c)     Any definitive agreement between Party A and a Manufacturing
                Licensee shall include a provision whereby the Manufacturing
                Licensee acknowledges (i) that it has no rights to distribute
                Products in the Asia Pacific Region and (ii) that Party B has
                the exclusive right to distribute Products in the Asia Pacific
                Region.

9.4     Notwithstanding the foregoing, a Manufacturing Licensee may enter into
        subcontracts with entities which do not comply with the requirements
        contained in Clause 9.3(b) in connection with any such manufacturing
        license for the manufacture of the Products in the Asia Pacific Region.

<PAGE>   40

10.     USE OF PARTY A'S TRADEMARKS AND LOGOS

10.1    Party A has the right to use, adopt, incorporate, show and display the
        name of Party A and all trade marks, service marks, business names and
        all marks, signs and logos of Party A and its affiliates, including all
        names, marks, signs and logos which may in the future be used or adopted
        by Party A and its affiliates for or in connection with the Products or
        the Services or the promotion or marketing thereof.

10.2    Party B shall during the term hereof have the right to use, adopt,
        incorporate, show and display the name of Party A, service marks,
        business names and all marks, signs and logos of Party A as exhibited in
        Schedule 10.2 and future service marks, business names and all marks,
        signs and logos of Party A from time to time ("the Licensed Mark") for
        and in connection with the Product and the manufacture, promotion and
        marketing thereof.

10.3    Party B must not modify or alter the Licensed Mark without the prior
        written consent of Party A, which consent shall not be withheld
        unreasonably where such modification or alteration solely relates to the
        use of the logo in any particular country or city in the Asia Pacific
        Region in which the Services are provided.

10.4    If any Licensed Mark is modified or altered under clause 10.3, the
        property in that mark shall be the property of Party B and Party A must
        assign to Party B all intellectual property rights arising out of the
        modification or alteration.

11.     QUALITY STANDARDS

11.1    Party A shall establish reasonable quality standards for the Products
        and Services provided under the Licensed Marks for the purpose of
        protecting the Licensed Marks as provided herein.

11.2    Party B agrees to adopt the quality standards established by Party A
        pursuant to Clause 11.1 for the Products and Services provided under the
        Licensed Marks as the minimum standard of quality for the Products and
        Services.

11.3    Party B shall have the right to create and distribute promotional and
        marketing literature and materials for the Products and Services using
        the Licensed Marks and materials and content provided by Party A. Party
        A shall have the right to control the quality of all promotional and
        marketing literature and materials bearing the Licensed Marks and Party
        B's use of the Licensed Marks.

11.4    Party A shall use reasonable efforts to promptly inform Party B of all
        of their marketing initiatives and advertising campaigns that would be
        reasonably likely to significantly affect the Asia Pacific Region for
        the Products and Services. Upon request by Party B, Party A shall
        provide copies of their advertising and promotional materials to assist
        Party B in the development of its own such materials for the Asia
        Pacific Region.

<PAGE>   41

11.5    Party A shall as soon as reasonably practicable include an appropriate
        reference approved by Party B on its internet home page (as well as
        certain of its advertising and promotional materials as determined in
        Party A's sole discretion) that the Products and Services in relation to
        the Asia Pacific Region are being granted and will be available to
        customers through Party B.

12.     REPRESENTATIONS AND WARRANTIES

12.1    Party A warrants and represents to Party B that:

        (a)     it is a corporation duly organized, validly existing and in good
                standing under the laws of the State of Delaware and it has the
                corporate power and is authorized under its Certificate of
                Incorporation and its Bylaws to carry on its business as now,
                and as proposed to be, conducted;

        (b)     it has performed all corporate actions and received all
                corporate authorizations necessary to execute and deliver this
                Agreement and to perform its obligations hereunder;

        (c)     this Agreement has been validly executed and delivered by it and
                constitutes the valid, binding and enforceable obligations of it
                in accordance with its terms;

        (d)     it has and shall maintain the power and authority and all
                material governmental licenses, authorizations, consents and
                approvals to be obtained within the United States to own its
                assets, carry on its business and to execute, deliver, and
                perform its obligations under this Agreement;

        (e)     except as set forth on Schedule 12 hereto, there are no (A)
                non-governmental third parties and (B) governmental or
                regulatory entities in the United States who are entitled to any
                notice of the transaction, licenses and services contemplated
                hereunder or whose consent is required to be obtained by Party A
                for the consummation of the transaction contemplated hereunder;

        (f)     except as set forth on Schedule 12 hereto, it is the sole and
                rightful owner of all right, title and interest in and to the
                Patented Technology and the Licensed Marks and all related
                intellectual property rights therein or holds adequate licenses
                or otherwise holds all rights necessary to use the Patented
                Technology and the Licensed Marks and all related intellectual
                property rights therein free and clear of all liens, claims and
                encumbrances, and it has the unrestricted right to market,
                license and exploit the Patented Technology and the Licensed
                Marks and all related intellectual property rights therein and
                such marketing, licensing and exploitation of the Patented
                Technology and the Licensed Marks and all related intellectual
                property rights therein will in no way constitute an
                infringement or other violation of any patent, copyright, trade
                secret, or trademark or other third party rights;

<PAGE>   42

        (g)     except as set forth on Schedule 12 hereto, no claims have been
                made in respect of the Patented Technology or Licensed Marks and
                any related intellectual property rights therein and no demands
                of any third party have been made pertaining to them, and no
                proceedings have been instituted or are pending or, to the best
                of its knowledge, threatened that challenge the rights of Party
                A in respect thereof; and

        (h)     All services by Party A to Party B will be provided in a
                professional, diligent and timely manner using staff
                knowledgeable and suitably qualified for the performance of the
                respective tasks for which they are responsible and Party A will
                use reasonable efforts to ensure that the quality and
                reliability of such services are no less favorable to Party B
                than the equivalent services provided by Party A it for its own
                purposes.

12.2    Party B warrants and represents to Party A that:

        (a)     it is a company duly organized, validly existing and in good
                standing under the laws of the jurisdiction of its formation;
                and it has the corporate power and is authorized under its
                Articles and Memorandum of Association to carry on its business
                as now, and as proposed to be, conducted;

        (b)     it has performed all corporate actions and received all
                corporate authorizations necessary to execute and deliver this
                Agreement and to perform its obligations hereunder;

        (c)     this Agreement has been validly executed and delivered by it and
                constitutes the valid, binding and enforceable obligations of it
                in accordance with its terms;

        (d)     it has and shall maintain the power and authority and all
                material governmental licenses, authorizations, consents and
                approvals to be obtained in Hong Kong, as necessary, to own its
                assets, carry on its business and to execute, deliver, and
                perform its obligations under this Agreement;

        (e)     it is in compliance with all requirements of any Hong Kong, or
                to the best of its knowledge, any other law (statutory or
                common), treaty, rule or regulation or determination of an
                arbitrator or of a governmental authority, in each case
                applicable to or binding upon it or any of its property or to
                which any of its business related to the Products is subject,
                except where failure to be in compliance could not reasonably be
                expected to have a material adverse change in, or a material
                adverse effect upon, the operations, business, properties or
                condition (financial or otherwise) of Party B taken as a whole
                (subject to obtaining any special governmental licenses required
                in any particular jurisdiction to manufacture, market, promote
                and/or distribute the Products);

        (f)     there are no (A) non-governmental third parties or (B)
                governmental or regulatory entities in Hong Kong who are
                entitled to any notice of the transactions

<PAGE>   43

                contemplated hereunder or whose consent is required to be
                obtained by Party B for the consummation of the transaction
                contemplated hereunder; and

        (g)     it has the staff, capacity, skill and experience to market and
                promote the Service and Products in the Asia Pacific Region.

13.     INDEMNIFICATION

13.1    Party A shall defend, indemnify and hold harmless Party B, its Related
        Companies and any sublicensees and any of their respective officers,
        directors, agents and employees (each a "Party B Indemnified Party")
        from and against any damages, liabilities, losses, claims, demands,
        judgments, suits, costs and expenses, including but not limited to
        reasonable attorneys' fees, if any, suffered or incurred by a Party B
        Indemnified Party as a result of any breach of any warranty or
        representation given by Party A hereunder, provided that (i) Party A is
        promptly notified of any and all threats, claims and proceedings related
        thereto, (ii) Party A shall have sole control of the defense and/or
        settlement of any claim or proceeding, except that Party A may not enter
        into such settlement without Party B's prior written consent thereto,
        which shall not be unreasonably withheld, (iii) Party B furnishes to
        Party A, upon request, information available to Party B for such
        defense, and (iv) Party B provides Party A with reasonable assistance at
        Party A's expense.

13.2    Party B shall defend, indemnify and hold harmless Party A and its
        Related Companies and any of their respective officers, directors,
        agents and employees (each a "Party A Indemnified Party") from and
        against any damages, liabilities, losses, claims, demands, judgments,
        suits, costs and expenses, including but not limited to reasonable
        attorneys' fees, if any, suffered or incurred by a Party A Indemnified
        Party as a result of any breach of any warranty or representation given
        by Party B hereunder.

14.     RIGHT TO SUB-LICENSE

14.1    Party B shall have the exclusive right to sub-license the Patented
        Technology, Know-How, Services and Licensed Marks to other persons or
        companies as necessary or required to distribute Products in the Asia
        Pacific Region. In addition, Party B shall have the exclusive right to
        sub-license the Distribution Right of Products to persons or other
        companies in the Asia Pacific Region only.

14.2    Any sub-licence granted by Party B:

        (a)     must expressly acknowledge and bind the sub-licensee to observe
                and preserve the rights of Party A granted under this Agreement;
                and

        (b)     must terminate immediately if this Agreement terminates for any
                reason whatsoever.

        (c)     Party B will ensure that the sub-licensee follows the quality
                standards set by Party A as per clause 11.1. Party B will
                include a clause in its sub-license agreement

<PAGE>   44

                that specifies compulsory quality compliance as part of the
                agreement for the sub-license.

15.     PARTY B'S RIGHT OF FIRST REFUSAL

        Party A agrees to negotiate in good faith a license agreement with Party
        B, prior to negotiating with any third party, for any and all new
        technology and know-how developed by Party A or its Related Company or
        its joint ventures, its partnerships or similar entities which are not
        directly related to or derivative of the Patented Technology and which
        does not constitute an update or modification to the Patented Technology
        (the "New Technology") for use in the Asia Pacific Region during the
        term of this Agreement, provided that no third party or partner of Party
        A that has ownership rights or a license to such New Technology (as a
        result of its support of the development of such New Technology) objects
        to such negotiations.

16.     INTELLECTUAL PROPERTY

16.1    To effect the physical transfer and/or operational availability of the
        Patented Technology by Party A to Party B, Party A shall provide to
        Party B, as soon as reasonably practicable after the Effective Date (and
        with respect to any modifications or updates, as soon as reasonably
        practical but no later than such modifications or updates are delivered
        to Party A's other customers or partners (joint venture or otherwise)),
        the Patented Technology in tangible form (including but not limited to
        those items described in Schedule 1.1). Party A agrees to undertake and
        provide services related to the Patented Technology and Services
        pursuant to this Agreement and as further mutually agreed to by the
        parties. Party A agrees to cooperate and, at the Party B's expense,
        assist in the filing of all patent applications in the Asia Pacific
        Region, assign existing patents and patent applications in the Asia
        Pacific Region, and take such other action for the protection of its
        rights in any jurisdiction within the Asia Pacific Region as reasonably
        requested by Party B; and, upon the completion of such registration,
        such rights shall be deemed to be Patented Technology hereunder. Any
        modifications or updates to the Patented Technology developed by Party B
        shall be owned solely by Party B. Party B agrees to negotiate in good
        faith a license agreement with Party A for any such modifications and
        updates.

16.2    Except as set forth in clause 16.1, the ownership of the Patented
        Technology and its modifications and updates shall remain with Party A.

16.3    If the Patented Technology contains any intellectual property belonging
        to third parties, Party A will notify Party B in writing of such third
        parties rights.

16.4    Party B will promptly notify Party A of any infringement of Party A's
        rights in or to the Patented Technology, Product and the Licensed Marks
        as soon as Party B is aware of such infringement. Party B agrees
        promptly to take such commercially reasonable steps and actions to
        protect and enforce Party A's right in or to the Patented Technology,
        Product and the Licensed Marks on the condition that Party A agrees to
        pay and indemnify Party B against all costs and liabilities that may be
        incurred by Party B.

<PAGE>   45

17.     CONFIDENTIALITY

17.1    "Confidential Information" means the confidential information of a party
        which relates to the subject matter of this Agreement and includes
        information relating to:

        (a)     the design, specification and content of the Patented
                Technology, the Product and the Services;

        (b)     the personnel, policies or business strategies of Party A and
                Party B; and

        (c)     the terms on which the Patented Technology and Product are being
                supplied and installed under this Agreement;

        all of which information is deemed proprietary.

17.2    A party must not, without the prior written approval of the other party,
        disclose the other party's Confidential Information.

17.3    It is not a breach of section 17 for a party to disclose Confidential
        Information which it is obliged by law to disclose to the person to whom
        it is disclosed or to the general public, if necessary or disclosure of
        Confidential Information in the ordinary course of a party's business
        provided such Confidential Information is not proprietary.

17.4    Each party must take all reasonable steps to ensure that its employees
        and agents, and any sub-contractors engaged for the purposes of this
        Agreement, do not make public or disclose the other party's Confidential
        Information.

17.5    Each party may at any time require the other party's employees, agents
        or sub-contractors engaged in the performance of this Agreement to
        execute a suitable confidentiality deed.

17.6    Each party must on demand return to each other any documents supplied by
        each other in connection with this Agreement.

17.7    Despite any other provision of this clause 17, each party may disclose
        the terms of this Agreement (other than Confidential Information of a
        technical nature) to its Related Company, solicitors, auditors, insurers
        or accountants, but must ensure that every person to whom that
        disclosure is made uses that information solely for the purposes of
        advising or reporting to such party.

17.8    This clause 17 survives the termination of this Agreement.

18.     MUTUAL EXCLUSIVITY

        Each party agrees that they will not during the term of this Agreement,
        engage or approach other third parties with a purpose of licensing,
        distributing or providing the

<PAGE>   46

        same or similar type of Patented Technology, in connection with the
        Product and Services, other than under the provisions of this Agreement.

19.     DEFAULT

19.1    Each of the following is an event of default ("Event of Default"):

        (a)     pursuant to the final decision of an arbitrator in accordance
                with clause 24 (if the Defaulting Party objects to the Notice of
                Default);

        (b)     any party fails to carry out any material provision of this
                Agreement and the failure is not capable of remedy or the
                failure is capable of remedy and such party does not remedy that
                failure within 30 days after written notice to the such party
                requiring it to be remedied; notwithstanding the foregoing,
                material breaches of clauses, other than clauses 2, 5, 10, 14
                and 17 by Party B, and other than clauses 2, 3, 4, 8, 9,
                12.1(f), 12.1(g), 14, 16 and 17 by Party A, shall not be Events
                of Default;

        (c)     it becomes unlawful for any party to perform its material
                obligations under clauses 2, 5, 9, 10 or 14 of this Agreement.

19.2    After an Event of Default occurs in relation to any party, the other
        party may, without prejudice to its other rights and remedies, terminate
        this Agreement by giving notice in writing to the defaulting party;
        provided, however, that if the Defaulting Party objects to such notice
        within 14 days, this agreement may be terminated only upon the final
        decision of an arbitrator in accordance with clause 24.

19.3    On termination of this Agreement under this clause 19.2 each party
        retains the rights it had against the other party in respect of any past
        breach, in addition to any other rights, powers or remedies provided by
        law.

19.4    In case an Event of Default occurs in relation to any party (the
        "Defaulting Party"), the Defaulting Party must on demand pay to the
        other party all of the expenses incurred by such other party in
        connection with the breach or default including the giving of a notice
        under clause 19.2 and otherwise in connection with the termination of
        this Agreement.

20.     TERMINATION

20.1    Notwithstanding the foregoing, Party A shall have the right to terminate
        this Agreement on thirty (30) days prior written notice if (i) the
        dollar amounts received by Party A under Section 5 hereof in any year,
        beginning in Party B's second accounting year, are less than US$50,000
        or (ii) if for any six month period beginning on that date which is six
        months after the date hereof Party B is either not actively
        manufacturing or marketing or distributing Products. Notwithstanding the
        foregoing, in the event that the dollar amounts received by Party A
        under Section 5 hereof (i) in the aggregate during the first five years
        of this Agreement are less than US$500,000 or (ii) in any year,
        beginning in year six

<PAGE>   47

        hereunder, are less than US$100,000, then the licenses granted hereunder
        shall become in all respects non-exclusive.

20.2    If, at any time during the term of this Agreement, Party A: (a) files a
        voluntary petition in bankruptcy under Chapter 7 or 11 of the United
        States Bankruptcy Code (the "Bankruptcy Code"); or (b) has an
        involuntary petition in bankruptcy filed against it under Chapter 7 of
        the Bankruptcy Code, which petition is not dismissed within ninety (90)
        days (each a "Party A Bankruptcy"), Party B may elect to retain its
        right in the licenses granted in this Agreement, subject to the terms of
        this Agreement, in accordance with Chapter 3, Section 365(n) of the
        Bankruptcy Code. The licenses granted in this Agreement will be deemed
        licenses of "intellectual property" under Section 365(n) of the
        Bankruptcy Code. In addition, in the event of a Party A Bankruptcy, the
        parties agree that such proceeding shall not affect the terms or
        validity of this Agreement.

20.3    Upon termination of this Agreement for any reason other than pursuant to
        clause 19.1(b) by reason of a material breach by Party A or by reason of
        Party A Bankruptcy, Party B shall automatically and without the parties
        having to take any action, assign, transfer and set over to Party A all
        right, title and interest to the Asian Patents. Party B shall agree to
        execute any and all instruments and documents reasonably requested by
        Party A to evidence such assignment. Party B will not, without Party A's
        prior written consent, transfer any interest in the Asian Patents other
        than the sublicenses contemplated hereunder

21.     LEGAL COSTS

        Each party shall bear and pay its own legal costs relating to the
        Licence and Distribution Agreement which inure after the date hereof.

22.     SEVERABILITY

        If any provision of this Agreement is held illegal, invalid or
        unenforceable by a court of competent jurisdiction or the parties
        otherwise mutually agree that a provision is or becomes illegal or
        invalid, that provision will be limited or eliminated to the minimum
        extent necessary so that this Agreement shall otherwise remain in full
        force and effect and enforceable.

23.     LAWS

        This Agreement shall be governed and interpreted in accordance with the
        laws of Hong Kong Special Administrative Region ("Hong Kong") of the
        People's Republic of China without regard to conflicts of law provisions
        thereof and without regard to the United Nations Convention on Contracts
        for the International Sale of Goods.

24.     ARBITRATION

<PAGE>   48

        The parties agree to submit all disputes arising out of the Licence and
        Distribution Agreement to arbitration in Hong Kong in accordance with
        the Model Law on International Commercial Arbitration adopted by the
        United Nations Commission on International Trade Law.

25.     NOTICES

        Any notice required or permitted to be given hereunder shall be in
        writing and shall be (a) personally delivered, (b) transmitted by
        internationally recognized air courier service, or (c) transmitted by
        facsimile, in each case to the parties as follows, as elected by the
        party giving such notice, to the other parties at the addresses set
        forth on the first page of this Agreement or as amended by notice
        pursuant to this subsection. Except as otherwise specified herein, all
        notices and other communications shall be deemed to have been duly given
        on (i) the date of receipt if delivered personally, (ii) three (3)
        Business Days after delivery to the courier, or (iii) the next Business
        Day in the jurisdiction of the recipient following the date of
        transmission with electronic confirmation if transmitted by facsimile,
        whichever shall first occur. Any party may change its address for
        purposes hereof by notice to the other parties. All notices and other
        communications shall be in the English language.

26.     ENTIRE AGREEMENT

        This Agreement, and all Attachments, schedules and exhibits hereto,
        supersedes all proposals, oral or written, all negotiations,
        conversations, or discussions between or among the parties relating to
        the subject matter of this Agreement and all past dealing or industry
        custom.

27.     COUNTERPARTS

        This Agreement may be executed in counterparts, each of which shall be
        deemed an original, but all of which together shall constitute one and
        the same instrument.

        IN WITNESS WHEREOF the parties have duly executed this Agreement the day
and year first above written.

                                      PHARMAPRINT INC.

                                      By:
                                          -----------------------------------
                                          Steven A. Bowman
                                          Its: Chief Executive Officer

                                      KINGSWAY PHARMAPRINT
                                      ASIA LIMITED

<PAGE>   49

                                      By:
                                          -----------------------------------
                                          Its:

<PAGE>   50

                                  SCHEDULE 1.1
                               PATENTED TECHNOLOGY

AUSTRALIA

<TABLE>
<CAPTION>
TITLE                                      FILING DATE  SERIAL NO.        STATUS
-----                                      -----------  ----------        ------
<S>                                        <C>          <C>               <C>
Pharmaceutical Grade Botanical Drugs       04/15/97     28131/97          Issued
Pharmaceutical Grade Echinacea             10/23/98     13634/99          Pending
Pharmaceutical Grade Ginkgo Biloba         10/23/98     13633/99          Pending
Pharmaceutical Grade Ginseng               10/23/98     11183/99          Pending
Pharmaceutical Grade Saw Palmetto,         10/23/98     13635/99          Pending
Serenoa Repens
Pharmaceutical Grade St. John's Wort       10/23/98     13631/99          Pending
Pharmaceutical Grade Valerian, Black       10/23/98     13632/99          Pending
Cohosh, Vitex Agnus-Castus, Bilberry and
Milk Thistle
</TABLE>

CANADA

<TABLE>
<CAPTION>
TITLE                                      FILING DATE  SERIAL NO.        STATUS
-----                                      -----------  ----------        ------
<S>                                        <C>          <C>               <C>
Pharmaceutical Grade Botanical Drugs       04/15/97     2252426           Pending
Pharmaceutical Grade Echinacea             10/23/98     2307614           Pending
Pharmaceutical Grade Garlic                10/23/98     2306812           Pending
Pharmaceutical Grade Ginkgo Biloba         10/23/98     2307194           Pending
Pharmaceutical Grade Ginseng               10/23/98     2307047           Pending
Pharmaceutical Grade Saw Palmetto,         10/23/98     2307602           Pending
Serenoa Repens
Pharmaceutical Grade St. John's Wort       10/23/98     2306818           Pending
Pharmaceutical Grade Valerian, Black       10/23/98     2307399           Pending
Cohosh, Vitex Agnus-Castus, Bilberry and
Milk Thistle
</TABLE>

CHINA

<TABLE>
<CAPTION>
TITLE                                      FILING DATE  SERIAL NO.        STATUS
-----                                      -----------  ----------        ------
<S>                                        <C>          <C>               <C>
Pharmaceutical Grade Botanical Drugs       04/15/97     97195565.4        Published
Pharmaceutical Grade Ginkgo Biloba         10/23/98     PCT/US98/22506    Pending
Pharmaceutical Grade Ginseng               10/23/98     N/A               Pending
</TABLE>

EUROPEAN PATENT CONVENT

<TABLE>
<CAPTION>
TITLE                                      FILING DATE  SERIAL NO.        STATUS
-----                                      -----------  ----------        ------
<S>                                        <C>          <C>               <C>
</TABLE>

<PAGE>   51

<TABLE>
<CAPTION>
                                           DATE
                                           ----
<S>                                        <C>          <C>                <C>
Mistletoe Extract and Method               04/13/96     96912546.7        Pending
Pharmaceutical Grade Botanical Drugs       04/15/97     97922474.8        Pending
Pharmaceutical Grade Echinacea             10/23/98     98957358.9        Published
Pharmaceutical Grade Ginkgo Biloba         10/23/98     98957357.1        Published
Pharmaceutical Grade Saw Palmetto,         10/23/98     N/A               Pending
Serenoa Repens
Pharmaceutical Grade St. John's Wort       10/23/98     98957355.5        Pending
</TABLE>

HONG KONG

<TABLE>
<CAPTION>
TITLE                                      FILING DATE  SERIAL NO.        STATUS
-----                                      -----------  ----------        ------
<S>                                        <C>          <C>               <C>
Pharmaceutical Grade Botanical Drugs       04/15/97     N/A               Pending
</TABLE>

JAPAN

<TABLE>
<CAPTION>
TITLE                                      FILING DATE  SERIAL NO.        STATUS
-----                                      -----------  ----------        ------
<S>                                        <C>          <C>               <C>
Mistletoe Extract and Method               04/3/96      08-531053         Pending
Pharmaceutical Grade Botanical Drugs       04/15/97     09-537454         Pending
Pharmaceutical Grade Ginkgo Biloba         10/23/98     2000-516688       Pending
Pharmaceutical Grade Ginseng               10/23/98     2000-516689       Pending
</TABLE>

MEXICO

<TABLE>
<CAPTION>
TITLE                                      FILING DATE  SERIAL NO.        STATUS
-----                                      -----------  ----------        ------
<S>                                        <C>          <C>               <C>
Pharmaceutical Grade Botanical Drugs       04/15/97     988527            Pending
</TABLE>

UNITED STATES

<TABLE>
<CAPTION>
TITLE                                      FILING DATE  SERIAL NO.        STATUS
-----                                      -----------  ----------        ------
<S>                                        <C>          <C>               <C>
Pharmaceutical Preparations Derived from   04/14/95     5,547,674         Issued
European Mistletoe
Pharmaceutical Preparations Derived from   04/14/95     5,565,200         Issued
Korean Mistletoe
Mistletoe Extract and Method               07/14/98     5,780,037         Issued
Pharmaceutical Grade Botanical Drugs       04/15/97     08/838,198        Pending
Pharmaceutical Grade Botanical Drugs       06/2/99      08/632,273        Pending
</TABLE>

<PAGE>   52

<TABLE>
<S>                                        <C>          <C>               <C>
Pharmaceutical Grade Valerian, Black       12/2/99      09/331,831        Pending
Cohosh, Vitex Agnus-Castus, Bilberry and
Milk Thistle
Pharmaceutical Grade Echinacea             06/23/99     09/331,797        Pending
Pharmaceutical Grade Garlic                06/23/99     09/331,824        Pending
Pharmaceutical Grade Ginkgo Biloba         06/23/99     09/331,827        Pending
Pharmaceutical Grade Saw Palmetto          10/23/97     6,039,950         Issued
Pharmaceutical Grade Saw Palmetto          08/20/99     09/378,774        Pending
Pharmaceutical Grade Saw Palmetto          06/23/99     09/331,832        Pending
Pharmaceutical Grade St. John's Wort       10/23/97     08/956,602        Allowed
Pharmaceutical Grade St. John's Wort       09/23/98     09/159,313        Pending
Standardized Functional Food Products      09/20/99     60/154,842        Pending
Pharmaceutical Grade Ginseng               10/22/98     09/177,702        Pending
</TABLE>

<PAGE>   53

                                  SCHEDULE 10.2

                                  LICENSED MARK

        United States:

1.      PharmaPrint: published for opposition.

2.      Three Leaf Logo: pending; office action was issued and has been
        addressed.

3.      PharmaPrint Certified: pending; office action was issued and has been
        addressed.

Canada:

1.      Notice of allowance given for PharmaPrint. Need to demonstrate that this
        mark has been commercially used in Canada to complete the registration.

2.      Notice of allowance given for Three Leaf Logo. Need to demonstrate that
        this mark has been commercially used in Canada to complete the
        registration.

Japan:

1.      Three Leaf Logo: is registered.

                        2.      PharmaPrint: is registered.

<PAGE>   54

                                   SCHEDULE 12

DISCLOSED MATTERS

Clause 12 (e): Consents to Transaction.

None.

Clause 12(f): Claims and Infringements.

None.

Clause 12(g): Claims and Proceedings.

None.<PAGE>   1

                                                                   EXHIBIT 10.18

                       Dated the 31st day of August, 2000

                                PHARMAPRINT INC.

                                       AND

                        KINGSWAY PHARMAPRINT ASIA LIMITED

                       LICENCE AND DISTRIBUTION AGREEMENT

<PAGE>   2

THIS LICENCE AND DISTRIBUTION AGREEMENT IS MADE THE 31ST DAY OF AUGUST, 2000.

BETWEEN

(1)     PHARMAPRINT INC, a company incorporated under the laws of Delaware,
        United States of America and having its registered office at 4701 Von
        Karman Avenue, Suite 201, Newport Beach, CA 92660, U.S.A. ("Party A");
        and

(2)     KINGSWAY PHARMAPRINT ASIA LIMITED, a company incorporated under the laws
        of the British Virgin Islands and whose registered office is situate at
        P.O. Box 957 Offshore Incorporations Center, Road Town, Tortola, British
        Virgin Islands ("Party B").

WHEREAS:

(A)     Party A is a company that develops, manufactures and markets dietary
        supplements, functional foods and pharmaceuticals derived from natural
        plant extracts. Party A is the proprietary owner of the PharmaPrint(TM)
        Process technology. The PharmaPrint(TM) Process technology enables the
        precise identification and consistent replication of the active
        ingredients from the natural plant extracts that are scientifically
        believed to provide the desired health benefits.

(B)     Party A has entered into a joint venture shareholders' agreement with
        Capital Alert Investments Limited, a company incorporated under the laws
        of the British Virgin Islands on August 31, 2000 for the formation and
        operation of Party B.

(C)     Party A has agreed to grant to Party B a licence for the manufacturing,
        marketing and distribution of the Product in the Asia Pacific Region as
        set forth herein.

NOW IT IS AGREED between the parties as follows:

1.      DEFINITIONS

1.1     In this Agreement, unless the context otherwise requires, the following
        expressions shall have the following meanings:

        "Asia Pacific Region" are countries within Asia Pacific, including but
        not limited to, Hong Kong, The People's Republic of China, North and
        South Korea, Japan, Singapore, Taiwan, Macau, Indonesia, Malaysia,
        Thailand, Vietnam, The Philippines, India, Pakistan, Brunei, Bangladesh,
        Sri Lanka, Papua New Guinea and Myanmar, Australia and New Zealand.

        "Know-How" means Party A's information and manufacturing directions,
        drawings, processing information, standards and specifications as to the
        materials to be used, control methods and test data necessary to
        manufacture Products.

<PAGE>   3

        "Patented Technology" means the PharmaPrint(TM) Process technology
        itemized on Schedule 1.1 hereto including the modifications and updates
        developed by Party A and its Related Company and as further modified
        pursuant to clause 16.1. Schedule 1.1 may be amended from time to time
        as Party A applies for or is issued additional patents.

        "Product" means the dietary supplements, functional foods and
        pharmaceuticals derived from natural plant extracts produced by Party B
        or any sublicensee, contractor or other third party using the Patented
        Technology.

        "Related Company" in respect of a company means its Subsidiary, its
        Holding Company or another company within the same Group of Companies as
        the first mentioned company (as those terms are defined in Section 2 of
        the Companies Ordinance (cap. 32)).

        "Services" means the provision of access rights, maintenance and usage
        of the Patented Technology to third parties, and training programs.

1.2     In this Agreement, unless the context otherwise requires, words
        importing a gender shall include every gender and words importing the
        singular shall include the plural and vice versa.

1.3     Headings in this Agreement are inserted for convenience only and shall
        be ignored in construing this Agreement.

2.      LICENCE AND DISTRIBUTION AGREEMENT

        2.1 Party A hereby assigns, transfers and sets over to Party B all
        right, title and interest to all patents, registrations and/or
        applications filed by Party A or its agent in any jurisdiction in the
        Asia Pacific Region as set forth on Schedule 1.1 (the "Asia Patents").
        Party A hereby grants Party B a non-exclusive (subject to Section 9),
        perpetual, royalty- free (except pursuant to Section 5) and fully-paid
        license (i) to use, modify, reproduce, display, make, deploy and
        otherwise exploit the Patented Technology, Know-How and the associated
        intellectual property rights therein in the manufacturing of the
        Products, and (ii) to sublicense any of the foregoing rights pursuant to
        Section 14 in any jurisdiction in the Asia Pacific Region (collectively,
        the "Technology License"), each during the term of this Agreement. Party
        A hereby grants Party B an exclusive, perpetual, royalty-free (except
        pursuant to Section 5) and fully-paid license (i) to use the Licensed
        Marks (as defined in Section 10.2) in the Asia Pacific Region and (ii)
        to sublicense any of the foregoing rights pursuant to Section 14 in any
        jurisdiction in the Asia Pacific Region (collectively, the "Trademark
        License"), each during the term of this Agreement. Party A hereby grants
        to Party B an exclusive and perpetual right and license to market,
        promote and distribute ("the Distribution Right") the Product in the
        Asia Pacific Region on the terms and conditions set out below during the
        term of this Agreement. Notwithstanding the foregoing, the Technology
        License, Trademark License and Distribution Right granted in this
        Section 2 (collectively, the "Licenses") shall not include the right to
        pharmaceutical discovery or development of any Product which

<PAGE>   4

        would require U.S. Food and Drug Administration approval or any similar
        U.S. government approval process prior to their sale. Party B hereby
        grants to Party A a perpetual, royalty free non-exclusive and fully paid
        license to use, modify, reproduce, display, make, deploy and otherwise
        exploit the Asia Patents and to sublicense any of the foregoing rights
        subject to the limits provided for herein, including, without
        limitation, such rights that are granted exclusively to Party B.

3.      PRODUCTS AND SERVICES

3.1     The Licences shall include the right to manufacture, market, promote and
        distribute the Product manufactured by using the Patented Technology in
        the Asia Pacific Region and the right to sublicense the Patented
        Technology and Know-How for the manufacture, marketing, promotion and
        distribution of Products in the Asia Pacific Region.

3.2     For the avoidance of doubt, Party B shall have the unfettered right
        subject to the terms and conditions hereof to lay down the terms and
        conditions for the use of the Patented Technology and Services by
        customers and charge such fees and conditions as Party B may think fit.

4.      CUSTOMIZATION AND LAUNCHING OF SERVICE

4.1     Party B shall have the right to test the Product, by itself or a
        qualified person, before the Launch Date to verify that the Product
        complies with the legal requirements and standards in the Asia Pacific
        Region.

4.2     Party A and Party B shall discuss from time to time the standard of the
        Product and seek ways to improve and upgrade the Product.

4.3     Party A shall use reasonable efforts to make all improvements,
        modifications, enhancements and updates to the Patented Technology and
        Know-How as Party A reasonably considers necessary, but Party B shall
        bear and pay all cost for the customization of such improvements,
        modifications, enhancements and updates for the Asia Pacific Region
        requested by Party B. Party A shall provide an estimated cost prior to
        the customization.

4.4     Party A shall provide operating manuals and training to the extent such
        exist (including update manuals and training) and technical support
        services to Party B and its staff in a timely manner. Party B shall
        reimburse Party A for its reasonable costs and expenses associated with
        providing such training and services, including, without limitation, the
        per diem salary costs of Party A employees providing requested training
        and support services and the reasonable expenses for necessary travel.

5.      ROYALTY

        In consideration of the granting of the Licences, Party B agrees to pay
        a royalty of 5% of the gross sales of Products and 5% of any other
        revenues generated directly or indirectly

<PAGE>   5

        from the Patented Technology or Know-How, less reasonable provisions for
        bad debts computed in accordance with international accounting standards
        or those generally accepted in Hong Kong and agreed between the parties.
        The royalty is payable to Party A within 30 days after the end of each
        calendar quarter (i.e. no later than April 30, July 30, October 30 and
        January 30).

6.      NAME OF THE PRODUCTS AND SERVICES

        The Product shall be launched under "PharmaPrint" or in such other
        manner as mutually agreed between the parties.

7.      PROMOTION

        Party B will promote the Product in Hong Kong and other countries or
        cities within the Asia Pacific Region as Party B shall deem appropriate
        and as governed by this Agreement.

8.      CUSTOMIZATION FOR OTHER ASIAN MARKETS

        If requested by Party B, Party A shall customize the Product, within a
        time table and costs mutually agreeable to both parties, for other
        countries or cities within the Asia Pacific Region in manner as
        requested by Party B so as to make the Product suitable for market and
        distribution in such countries or cities. Party B shall have the same
        right to promote, market and use all such technology and know-how in the
        same manner as set out above.

9.      EXCLUSIVE AND PERPETUAL RIGHT

9.1     Party B shall have the perpetual, non-exclusive right to use the
        Patented Technology and Know-How to manufacture the Product during the
        term hereof and the exclusive and perpetual right and license to market
        and distribute the Product within the Asia Pacific Region during the
        term hereof as provided in Section 2 hereof.

9.2     Subject to the proviso in Section 2 hereof, Party A shall not, and shall
        not permit any other person except Party B during the license period to:

        (a)     license in connection with the sale or distribution of Product,
                the Patented Technology and Know-How or similar technology and
                know-how to any person or company within the Asia Pacific
                Region, or

        (b)     license in connection with the sale or distribution of Product,
                any person or company to use the Patented Technology and
                Know-How or any similar technology and know-how developed by
                Party A or its Related Companies in the Asia Pacific Region, or

<PAGE>   6

        (c)     license in connection with the sale or distribution of Product,
                any person or company to use the Patented Technology and
                Know-How or any similar technology and know-how developed by
                Party A or its Related Companies in a way as to compete with
                Party B's business in the Asia Pacific Region, or

        (d)     market and distribute the Product or similar products in the
                Asia Pacific Region utilizing the Patented Technology and
                Know-How or any similar technology and know-how in a way as to
                compete with Party B's business or license any third party to do
                any of the same.

9.3     Notwithstanding the foregoing, in the event that any third party (a
        "Manufacturing Licensee") will obtain a license to the Patented
        Technology, Know-How or similar technology from Party A or its Related
        Companies for the manufacture of the Products in the Asia Pacific
        Region:

        (a)     Party A shall provide to Party B prompt written notice of
                negotiations with a potential Manufacturing Licensee prior to
                the date that Party A and such Manufacturing Licensee enter into
                a definitive agreement(s);

        (b)     The shares of such Manufacturing Licensee's capital stock must
                be listed on the New York Stock Exchange or on the Nasdaq
                National Market; and

        (c)     Any definitive agreement between Party A and a Manufacturing
                Licensee shall include a provision whereby the Manufacturing
                Licensee acknowledges (i) that it has no rights to distribute
                Products in the Asia Pacific Region and (ii) that Party B has
                the exclusive right to distribute Products in the Asia Pacific
                Region.

9.4     Notwithstanding the foregoing, a Manufacturing Licensee may enter into
        subcontracts with entities which do not comply with the requirements
        contained in Clause 9.3(b) in connection with any such manufacturing
        license for the manufacture of the Products in the Asia Pacific Region.

<PAGE>   7

10.     USE OF PARTY A'S TRADEMARKS AND LOGOS

10.1    Party A has the right to use, adopt, incorporate, show and display the
        name of Party A and all trade marks, service marks, business names and
        all marks, signs and logos of Party A and its affiliates, including all
        names, marks, signs and logos which may in the future be used or adopted
        by Party A and its affiliates for or in connection with the Products or
        the Services or the promotion or marketing thereof.

10.2    Party B shall during the term hereof have the right to use, adopt,
        incorporate, show and display the name of Party A, service marks,
        business names and all marks, signs and logos of Party A as exhibited in
        Schedule 10.2 and future service marks, business names and all marks,
        signs and logos of Party A from time to time ("the Licensed Mark") for
        and in connection with the Product and the manufacture, promotion and
        marketing thereof.

10.3    Party B must not modify or alter the Licensed Mark without the prior
        written consent of Party A, which consent shall not be withheld
        unreasonably where such modification or alteration solely relates to the
        use of the logo in any particular country or city in the Asia Pacific
        Region in which the Services are provided.

10.4    If any Licensed Mark is modified or altered under clause 10.3, the
        property in that mark shall be the property of Party B and Party A must
        assign to Party B all intellectual property rights arising out of the
        modification or alteration.

11.     QUALITY STANDARDS

11.1    Party A shall establish reasonable quality standards for the Products
        and Services provided under the Licensed Marks for the purpose of
        protecting the Licensed Marks as provided herein.

11.2    Party B agrees to adopt the quality standards established by Party A
        pursuant to Clause 11.1 for the Products and Services provided under the
        Licensed Marks as the minimum standard of quality for the Products and
        Services.

11.3    Party B shall have the right to create and distribute promotional and
        marketing literature and materials for the Products and Services using
        the Licensed Marks and materials and content provided by Party A. Party
        A shall have the right to control the quality of all promotional and
        marketing literature and materials bearing the Licensed Marks and Party
        B's use of the Licensed Marks.

11.4    Party A shall use reasonable efforts to promptly inform Party B of all
        of their marketing initiatives and advertising campaigns that would be
        reasonably likely to significantly affect the Asia Pacific Region for
        the Products and Services. Upon request by Party B, Party A shall
        provide copies of their advertising and promotional materials to assist
        Party B in the development of its own such materials for the Asia
        Pacific Region.

<PAGE>   8

11.5    Party A shall as soon as reasonably practicable include an appropriate
        reference approved by Party B on its internet home page (as well as
        certain of its advertising and promotional materials as determined in
        Party A's sole discretion) that the Products and Services in relation to
        the Asia Pacific Region are being granted and will be available to
        customers through Party B.

12.     REPRESENTATIONS AND WARRANTIES

12.1    Party A warrants and represents to Party B that:

        (a)     it is a corporation duly organized, validly existing and in good
                standing under the laws of the State of Delaware and it has the
                corporate power and is authorized under its Certificate of
                Incorporation and its Bylaws to carry on its business as now,
                and as proposed to be, conducted;

        (b)     it has performed all corporate actions and received all
                corporate authorizations necessary to execute and deliver this
                Agreement and to perform its obligations hereunder;

        (c)     this Agreement has been validly executed and delivered by it and
                constitutes the valid, binding and enforceable obligations of it
                in accordance with its terms;

        (d)     it has and shall maintain the power and authority and all
                material governmental licenses, authorizations, consents and
                approvals to be obtained within the United States to own its
                assets, carry on its business and to execute, deliver, and
                perform its obligations under this Agreement;

        (e)     except as set forth on Schedule 12 hereto, there are no (A)
                non-governmental third parties and (B) governmental or
                regulatory entities in the United States who are entitled to any
                notice of the transaction, licenses and services contemplated
                hereunder or whose consent is required to be obtained by Party A
                for the consummation of the transaction contemplated hereunder;

        (f)     except as set forth on Schedule 12 hereto, it is the sole and
                rightful owner of all right, title and interest in and to the
                Patented Technology and the Licensed Marks and all related
                intellectual property rights therein or holds adequate licenses
                or otherwise holds all rights necessary to use the Patented
                Technology and the Licensed Marks and all related intellectual
                property rights therein free and clear of all liens, claims and
                encumbrances, and it has the unrestricted right to market,
                license and exploit the Patented Technology and the Licensed
                Marks and all related intellectual property rights therein and
                such marketing, licensing and exploitation of the Patented
                Technology and the Licensed Marks and all related intellectual
                property rights therein will in no way constitute an
                infringement or other violation of any patent, copyright, trade
                secret, or trademark or other third party rights;

<PAGE>   9

        (g)     except as set forth on Schedule 12 hereto, no claims have been
                made in respect of the Patented Technology or Licensed Marks and
                any related intellectual property rights therein and no demands
                of any third party have been made pertaining to them, and no
                proceedings have been instituted or are pending or, to the best
                of its knowledge, threatened that challenge the rights of Party
                A in respect thereof; and

        (h)     All services by Party A to Party B will be provided in a
                professional, diligent and timely manner using staff
                knowledgeable and suitably qualified for the performance of the
                respective tasks for which they are responsible and Party A will
                use reasonable efforts to ensure that the quality and
                reliability of such services are no less favorable to Party B
                than the equivalent services provided by Party A it for its own
                purposes.

12.2    Party B warrants and represents to Party A that:

        (a)     it is a company duly organized, validly existing and in good
                standing under the laws of the jurisdiction of its formation;
                and it has the corporate power and is authorized under its
                Articles and Memorandum of Association to carry on its business
                as now, and as proposed to be, conducted;

        (b)     it has performed all corporate actions and received all
                corporate authorizations necessary to execute and deliver this
                Agreement and to perform its obligations hereunder;

        (c)     this Agreement has been validly executed and delivered by it and
                constitutes the valid, binding and enforceable obligations of it
                in accordance with its terms;

        (d)     it has and shall maintain the power and authority and all
                material governmental licenses, authorizations, consents and
                approvals to be obtained in Hong Kong, as necessary, to own its
                assets, carry on its business and to execute, deliver, and
                perform its obligations under this Agreement;

        (e)     it is in compliance with all requirements of any Hong Kong, or
                to the best of its knowledge, any other law (statutory or
                common), treaty, rule or regulation or determination of an
                arbitrator or of a governmental authority, in each case
                applicable to or binding upon it or any of its property or to
                which any of its business related to the Products is subject,
                except where failure to be in compliance could not reasonably be
                expected to have a material adverse change in, or a material
                adverse effect upon, the operations, business, properties or
                condition (financial or otherwise) of Party B taken as a whole
                (subject to obtaining any special governmental licenses required
                in any particular jurisdiction to manufacture, market, promote
                and/or distribute the Products);

        (f)     there are no (A) non-governmental third parties or (B)
                governmental or regulatory entities in Hong Kong who are
                entitled to any notice of the transactions

<PAGE>   10

                contemplated hereunder or whose consent is required to be
                obtained by Party B for the consummation of the transaction
                contemplated hereunder; and

        (g)     it has the staff, capacity, skill and experience to market and
                promote the Service and Products in the Asia Pacific Region.

13.     INDEMNIFICATION

13.1    Party A shall defend, indemnify and hold harmless Party B, its Related
        Companies and any sublicensees and any of their respective officers,
        directors, agents and employees (each a "Party B Indemnified Party")
        from and against any damages, liabilities, losses, claims, demands,
        judgments, suits, costs and expenses, including but not limited to
        reasonable attorneys' fees, if any, suffered or incurred by a Party B
        Indemnified Party as a result of any breach of any warranty or
        representation given by Party A hereunder, provided that (i) Party A is
        promptly notified of any and all threats, claims and proceedings related
        thereto, (ii) Party A shall have sole control of the defense and/or
        settlement of any claim or proceeding, except that Party A may not enter
        into such settlement without Party B's prior written consent thereto,
        which shall not be unreasonably withheld, (iii) Party B furnishes to
        Party A, upon request, information available to Party B for such
        defense, and (iv) Party B provides Party A with reasonable assistance at
        Party A's expense.

13.2    Party B shall defend, indemnify and hold harmless Party A and its
        Related Companies and any of their respective officers, directors,
        agents and employees (each a "Party A Indemnified Party") from and
        against any damages, liabilities, losses, claims, demands, judgments,
        suits, costs and expenses, including but not limited to reasonable
        attorneys' fees, if any, suffered or incurred by a Party A Indemnified
        Party as a result of any breach of any warranty or representation given
        by Party B hereunder.

14.     RIGHT TO SUB-LICENSE

14.1    Party B shall have the exclusive right to sub-license the Patented
        Technology, KnowHow, Services and Licensed Marks to other persons or
        companies as necessary or required to distribute Products in the Asia
        Pacific Region. In addition, Party B shall have the exclusive right to
        sub-license the Distribution Right of Products to persons or other
        companies in the Asia Pacific Region only.

14.2    Any sub-licence granted by Party B:

        (a)     must expressly acknowledge and bind the sub-licensee to observe
                and preserve the rights of Party A granted under this Agreement;
                and

        (b)     must terminate immediately if this Agreement terminates for any
                reason whatsoever.

<PAGE>   11

        (c)     Party B will ensure that the sub-licensee follows the quality
                standards set by Party A as per clause 11.1. Party B will
                include a clause in its sub-license agreement that specifies
                compulsory quality compliance as part of the agreement for the
                sub-license.

15.     PARTY B'S RIGHT OF FIRST REFUSAL

        Party A agrees to negotiate in good faith a license agreement with Party
        B, prior to negotiating with any third party, for any and all new
        technology and know-how developed by Party A or its Related Company or
        its joint ventures, its partnerships or similar entities which are not
        directly related to or derivative of the Patented Technology and which
        does not constitute an update or modification to the Patented Technology
        (the "New Technology") for use in the Asia Pacific Region during the
        term of this Agreement, provided that no third party or partner of Party
        A that has ownership rights or a license to such New Technology (as a
        result of its support of the development of such New Technology) objects
        to such negotiations.

16.     INTELLECTUAL PROPERTY

16.1    To effect the physical transfer and/or operational availability of the
        Patented Technology by Party A to Party B, Party A shall provide to
        Party B, as soon as reasonably practicable after the Effective Date (and
        with respect to any modifications or updates, as soon as reasonably
        practical but no later than such modifications or updates are delivered
        to Party A's other customers or partners (joint venture or otherwise)),
        the Patented Technology in tangible form (including but not limited to
        those items described in Schedule 1.1). Party A agrees to undertake and
        provide services related to the Patented Technology and Services
        pursuant to this Agreement and as further mutually agreed to by the
        parties. Party A agrees to cooperate and, at the Party B's expense,
        assist in the filing of all patent applications in the Asia Pacific
        Region, assign existing patents and patent applications in the Asia
        Pacific Region, and take such other action for the protection of its
        rights in any jurisdiction within the Asia Pacific Region as reasonably
        requested by Party B; and, upon the completion of such registration,
        such rights shall be deemed to be Patented Technology hereunder. Any
        modifications or updates to the Patented Technology developed by Party B
        shall be owned solely by Party B. Party B agrees to negotiate in good
        faith a license agreement with Party A for any such modifications and
        updates.

16.2    Except as set forth in clause 16.1, the ownership of the Patented
        Technology and its modifications and updates shall remain with Party A.

16.3    If the Patented Technology contains any intellectual property belonging
        to third parties, Party A will notify Party B in writing of such third
        parties rights.

16.4    Party B will promptly notify Party A of any infringement of Party A's
        rights in or to the Patented Technology, Product and the Licensed Marks
        as soon as Party B is aware of such infringement. Party B agrees
        promptly to take such commercially reasonable steps and actions to
        protect and enforce Party A's right in or to the Patented Technology,

<PAGE>   12

        Product and the Licensed Marks on the condition that Party A agrees to
        pay and indemnify Party B against all costs and liabilities that may be
        incurred by Party B.

17.     CONFIDENTIALITY

17.1    "Confidential Information" means the confidential information of a party
        which relates to the subject matter of this Agreement and includes
        information relating to:

        (a)     the design, specification and content of the Patented
                Technology, the Product and the Services;

        (b)     the personnel, policies or business strategies of Party A and
                Party B; and

        (c)     the terms on which the Patented Technology and Product are being
                supplied and installed under this Agreement;

        all of which information is deemed proprietary.

17.2    A party must not, without the prior written approval of the other party,
        disclose the other party's Confidential Information.

17.3    It is not a breach of section 17 for a party to disclose Confidential
        Information which it is obliged by law to disclose to the person to whom
        it is disclosed or to the general public, if necessary or disclosure of
        Confidential Information in the ordinary course of a party's business
        provided such Confidential Information is not proprietary.

17.4    Each party must take all reasonable steps to ensure that its employees
        and agents, and any sub-contractors engaged for the purposes of this
        Agreement, do not make public or disclose the other party's Confidential
        Information.

17.5    Each party may at any time require the other party's employees, agents
        or sub-contractors engaged in the performance of this Agreement to
        execute a suitable confidentiality deed.

17.6    Each party must on demand return to each other any documents supplied by
        each other in connection with this Agreement.

17.7    Despite any other provision of this clause 17, each party may disclose
        the terms of this Agreement (other than Confidential Information of a
        technical nature) to its Related Company, solicitors, auditors, insurers
        or accountants, but must ensure that every person to whom that
        disclosure is made uses that information solely for the purposes of
        advising or reporting to such party.

17.8    This clause 17 survives the termination of this Agreement.

18.     MUTUAL EXCLUSIVITY

<PAGE>   13

        Each party agrees that they will not during the term of this Agreement,
        engage or approach other third parties with a purpose of licensing,
        distributing or providing the same or similar type of Patented
        Technology, in connection with the Product and Services, other than
        under the provisions of this Agreement.

19.     DEFAULT

19.1    Each of the following is an event of default ("Event of Default"):

        (a)     pursuant to the final decision of an arbitrator in accordance
                with clause 24 (if the Defaulting Party objects to the Notice of
                Default);

        (b)     any party fails to carry out any material provision of this
                Agreement and the failure is not capable of remedy or the
                failure is capable of remedy and such party does not remedy that
                failure within 30 days after written notice to the such party
                requiring it to be remedied; notwithstanding the foregoing,
                material breaches of clauses, other than clauses 2, 5, 10, 14
                and 17 by Party B, and other than clauses 2, 3, 4, 8, 9,
                12.1(f), 12.1(g), 14, 16 and 17 by Party A, shall not be Events
                of Default;

        (c)     it becomes unlawful for any party to perform its material
                obligations under clauses 2, 5, 9, 10 or 14 of this Agreement.

19.2    After an Event of Default occurs in relation to any party, the other
        party may, without prejudice to its other rights and remedies, terminate
        this Agreement by giving notice in writing to the defaulting party;
        provided, however, that if the Defaulting Party objects to such notice
        within 14 days, this agreement may be terminated only upon the final
        decision of an arbitrator in accordance with clause 24.

19.3    On termination of this Agreement under this clause 19.2 each party
        retains the rights it had against the other party in respect of any past
        breach, in addition to any other rights, powers or remedies provided by
        law.

19.4    In case an Event of Default occurs in relation to any party (the
        "Defaulting Party"), the Defaulting Party must on demand pay to the
        other party all of the expenses incurred by such other party in
        connection with the breach or default including the giving of a notice
        under clause 19.2 and otherwise in connection with the termination of
        this Agreement.

20.     TERMINATION

20.1    Notwithstanding the foregoing, Party A shall have the right to terminate
        this Agreement on thirty (30) days prior written notice if (i) the
        dollar amounts received by Party A under Section 5 hereof in any year,
        beginning in Party B's second accounting year, are less than US$50,000
        or (ii) if for any six month period beginning on that date which is six
        months after the date hereof Party B is either not actively
        manufacturing or marketing or distributing Products. Notwithstanding the
        foregoing, in the event that the dollar amounts

<PAGE>   14

        received by Party A under Section 5 hereof (i) in the aggregate during
        the first five years of this Agreement are less than US$500,000 or (ii)
        in any year, beginning in year six hereunder, are less than US$100,000,
        then the licenses granted hereunder shall become in all respects
        non-exclusive.

20.2    If, at any time during the term of this Agreement, Party A: (a) files a
        voluntary petition in bankruptcy under Chapter 7 or 11 of the United
        States Bankruptcy Code (the "Bankruptcy Code"); or (b) has an
        involuntary petition in bankruptcy filed against it under Chapter 7 of
        the Bankruptcy Code, which petition is not dismissed within ninety (90)
        days (each a "Party A Bankruptcy"), Party B may elect to retain its
        right in the licenses granted in this Agreement, subject to the terms of
        this Agreement, in accordance with Chapter 3, Section 365(n) of the
        Bankruptcy Code. The licenses granted in this Agreement will be deemed
        licenses of "intellectual property" under Section 365(n) of the
        Bankruptcy Code. In addition, in the event of a Party A Bankruptcy, the
        parties agree that such proceeding shall not affect the terms or
        validity of this Agreement.

20.3    Upon termination of this Agreement for any reason other than pursuant to
        clause 19.1(b) by reason of a material breach by Party A or by reason of
        Party A Bankruptcy, Party B shall automatically and without the parties
        having to take any action, assign, transfer and set over to Party A all
        right, title and interest to the Asian Patents. Party B shall agree to
        execute any and all instruments and documents reasonably requested by
        Party A to evidence such assignment. Party B will not, without Party A's
        prior written consent, transfer any interest in the Asian Patents other
        than the sublicenses contemplated hereunder

21.     LEGAL COSTS

        Each party shall bear and pay its own legal costs relating to the
        Licence and Distribution Agreement which inure after the date hereof.

22.     SEVERABILITY

        If any provision of this Agreement is held illegal, invalid or
        unenforceable by a court of competent jurisdiction or the parties
        otherwise mutually agree that a provision is or becomes illegal or
        invalid, that provision will be limited or eliminated to the minimum
        extent necessary so that this Agreement shall otherwise remain in full
        force and effect and enforceable.

23.     LAWS

        This Agreement shall be governed and interpreted in accordance with the
        laws of Hong Kong Special Administrative Region ("Hong Kong") of the
        People's Republic of China without regard to conflicts of law provisions
        thereof and without regard to the United Nations Convention on Contracts
        for the International Sale of Goods.

24.     ARBITRATION

<PAGE>   15

        The parties agree to submit all disputes arising out of the Licence and
        Distribution Agreement to arbitration in Hong Kong in accordance with
        the Model Law on International Commercial Arbitration adopted by the
        United Nations Commission on International Trade Law.

25.     NOTICES

        Any notice required or permitted to be given hereunder shall be in
        writing and shall be (a) personally delivered, (b) transmitted by
        internationally recognized air courier service, or (c) transmitted by
        facsimile, in each case to the parties as follows, as elected by the
        party giving such notice, to the other parties at the addresses set
        forth on the first page of this Agreement or as amended by notice
        pursuant to this subsection. Except as otherwise specified herein, all
        notices and other communications shall be deemed to have been duly given
        on (i) the date of receipt if delivered personally, (ii) three (3)
        Business Days after delivery to the courier, or (iii) the next Business
        Day in the jurisdiction of the recipient following the date of
        transmission with electronic confirmation if transmitted by facsimile,
        whichever shall first occur. Any party may change its address for
        purposes hereof by notice to the other parties. All notices and other
        communications shall be in the English language.

26.     ENTIRE AGREEMENT

        This Agreement, and all Attachments, schedules and exhibits hereto,
        supersedes all proposals, oral or written, all negotiations,
        conversations, or discussions between or among the parties relating to
        the subject matter of this Agreement and all past dealing or industry
        custom.

27.     COUNTERPARTS

        This Agreement may be executed in counterparts, each of which shall be
        deemed an original, but all of which together shall constitute one and
        the same instrument.

        IN WITNESS WHEREOF the parties have duly executed this Agreement the day
and year first above written.

                                      PHARMAPRINT INC.

                                      By:
                                          -----------------------------------
                                          Steven A. Bowman
                                          Its: Chief Executive Officer

                                      KINGSWAY PHARMAPRINT
                                      ASIA LIMITED

<PAGE>   16

                                      By:
                                         -----------------------------------
                                                      Its:

<PAGE>   17

                                  SCHEDULE 1.1
                               PATENTED TECHNOLOGY

AUSTRALIA

<TABLE>
<CAPTION>
TITLE                                      FILING DATE  SERIAL NO.        STATUS
-----                                      -----------  ----------        ------
<S>                                        <C>          <C>               <C>
Pharmaceutical Grade Botanical Drugs       04/15/97     28131/97          Issued
Pharmaceutical Grade Echinacea             10/23/98     13634/99          Pending
Pharmaceutical Grade Ginkgo Biloba         10/23/98     13633/99          Pending
Pharmaceutical Grade Ginseng               10/23/98     11183/99          Pending
Pharmaceutical Grade Saw Palmetto,         10/23/98     13635/99          Pending
Serenoa Repens
Pharmaceutical Grade St. John's Wort       10/23/98     13631/99          Pending
Pharmaceutical Grade Valerian, Black       10/23/98     13632/99          Pending
Cohosh, Vitex Agnus-Castus, Bilberry and
Milk Thistle
</TABLE>

CANADA

<TABLE>
<CAPTION>
TITLE                                      FILING DATE  SERIAL NO.        STATUS
-----                                      -----------  ----------        ------
<S>                                        <C>          <C>               <C>
Pharmaceutical Grade Botanical Drugs       04/15/97     2252426           Pending
Pharmaceutical Grade Echinacea             10/23/98     2307614           Pending
Pharmaceutical Grade Garlic                10/23/98     2306812           Pending
Pharmaceutical Grade Ginkgo Biloba         10/23/98     2307194           Pending
Pharmaceutical Grade Ginseng               10/23/98     2307047           Pending
Pharmaceutical Grade Saw Palmetto,         10/23/98     2307602           Pending
Serenoa Repens
Pharmaceutical Grade St. John's Wort       10/23/98     2306818           Pending
Pharmaceutical Grade Valerian, Black       10/23/98     2307399           Pending
Cohosh, Vitex Agnus-Castus, Bilberry and
Milk Thistle
</TABLE>

CHINA

<TABLE>
<CAPTION>
TITLE                                      FILING DATE  SERIAL NO.        STATUS
-----                                      -----------  ----------        ------
<S>                                        <C>          <C>               <C>
Pharmaceutical Grade Botanical Drugs       04/15/97     97195565.4         Published
Pharmaceutical Grade Ginkgo Biloba         10/23/98     PCT/US98/22506     Pending
Pharmaceutical Grade Ginseng               10/23/98     N/A                Pending
</TABLE>

EUROPEAN PATENT CONVENT

<TABLE>
<CAPTION>
TITLE                                      FILING DATE  SERIAL NO.        STATUS
-----                                      -----------  ----------        ------
<S>                                        <C>          <C>               <C>
</TABLE>

<PAGE>   18

<TABLE>
<CAPTION>
                                           DATE
                                           ----
<S>                                        <C>          <C>                <C>
Mistletoe Extract and Method               04/13/96     96912546.7         Pending
Pharmaceutical Grade Botanical Drugs       04/15/97     97922474.8         Pending
Pharmaceutical Grade Echinacea             10/23/98     98957358.9         Published
Pharmaceutical Grade Ginkgo Biloba         10/23/98     98957357.1         Published
Pharmaceutical Grade Saw Palmetto,         10/23/98     N/A                Pending
Serenoa Repens
Pharmaceutical Grade St. John's Wort       10/23/98     98957355.5         Pending
</TABLE>

HONG KONG

<TABLE>
<CAPTION>
TITLE                                      FILING DATE  SERIAL NO.        STATUS
-----                                      -----------  ----------        ------
<S>                                        <C>          <C>               <C>
Pharmaceutical Grade Botanical Drugs       04/15/97     N/A                Pending
</TABLE>

JAPAN

<TABLE>
<CAPTION>
TITLE                                      FILING DATE  SERIAL NO.        STATUS
-----                                      -----------  ----------        ------
<S>                                        <C>          <C>               <C>
Mistletoe Extract and Method               04/3/96      08-531053         Pending
Pharmaceutical Grade Botanical Drugs       04/15/97     09-537454         Pending
Pharmaceutical Grade Ginkgo Biloba         10/23/98     2000-516688       Pending
Pharmaceutical Grade Ginseng               10/23/98     2000-516689       Pending
</TABLE>

MEXICO

<TABLE>
<CAPTION>
TITLE                                      FILING DATE  SERIAL NO.        STATUS
-----                                      -----------  ----------        ------
<S>                                        <C>          <C>               <C>
Pharmaceutical Grade Botanical Drugs       04/15/97     988527            Pending
</TABLE>

UNITED STATES

<TABLE>
<CAPTION>
TITLE                                      FILING DATE  SERIAL NO.        STATUS
-----                                      -----------  ----------        ------
<S>                                        <C>          <C>               <C>
Pharmaceutical Preparations Derived from   04/14/95     5,547,674         Issued
European Mistletoe
Pharmaceutical Preparations Derived from   04/14/95     5,565,200         Issued
Korean Mistletoe
Mistletoe Extract and Method               07/14/98     5,780,037         Issued
Pharmaceutical Grade Botanical Drugs       04/15/97     08/838,198        Pending
Pharmaceutical Grade Botanical Drugs       06/2/99      08/632,273        Pending
</TABLE>

<PAGE>   19

<TABLE>
<S>                                        <C>          <C>               <C>
Pharmaceutical Grade Valerian, Black       12/2/99      09/331,831        Pending
Cohosh, Vitex Agnus-Castus, Bilberry and
Milk Thistle
Pharmaceutical Grade Echinacea             06/23/99     09/331,797        Pending
Pharmaceutical Grade Garlic                06/23/99     09/331,824        Pending
Pharmaceutical Grade Ginkgo Biloba         06/23/99     09/331,827        Pending
Pharmaceutical Grade Saw Palmetto          10/23/97     6,039,950         Issued
Pharmaceutical Grade Saw Palmetto          08/20/99     09/378,774        Pending
Pharmaceutical Grade Saw Palmetto          06/23/99     09/331,832        Pending
Pharmaceutical Grade St. John's Wort       10/23/97     08/956,602        Allowed
Pharmaceutical Grade St. John's Wort       09/23/98     09/159,313        Pending
Standardized Functional Food Products      09/20/99     60/154,842        Pending
Pharmaceutical Grade Ginseng               10/22/98     09/177,702        Pending
</TABLE>

<PAGE>   20

                                  SCHEDULE 10.2

                                  LICENSED MARK

        United States:

1.      PharmaPrint: published for opposition.

2.      Three Leaf Logo: pending; office action was issued and has been
        addressed.

3.      PharmaPrint Certified: pending; office action was issued and has been
        addressed.

Canada:

1.      Notice of allowance given for PharmaPrint. Need to demonstrate that this
        mark has been commercially used in Canada to complete the registration.

2.      Notice of allowance given for Three Leaf Logo. Need to demonstrate that
        this mark has been commercially used in Canada to complete the
        registration.

Japan:

1.      Three Leaf Logo: is registered.

                        2.      PharmaPrint: is registered.

<PAGE>   21

                                   SCHEDULE 12

DISCLOSED MATTERS

Clause 12 (e): Consents to Transaction.

None.

Clause 12(f): Claims and Infringements.

None.

Clause 12(g): Claims and Proceedings.

None.

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