Document:

EXHIBIT 10.3

 

TRANSFER AND

TERMINATION AGREEMENT

 

DATED May 6, 2015 ("Effective
Date")

 

Parties:

Sucampo AG, incorporated and registered
in Switzerland with offices at Baarerstrasse 22, CH- 6300 Zug, Switzerland and its affiliates ("Sucampo"), and R-Tech
Ueno, Ltd. Incorporated and registered in Japan with offices at 10F, NBF Hibiya Building, 1-1-7, Uchisaiwaicho, Chiyoda-ku, Tokyo
100-0011 ("R-Tech"). Hereinafter referred to as "Party" and together, the "Parties".

 

Preamble:

Whereas, an affiliate
of Sucampo AG, Sucampo Pharma Americas, Inc. and R-Tech entered into the Unoprostone NDA Transfer, Patent and Know-how Licensing,
and Data Sharing Agreement effective April 23, 2009 (the "2009 License Agreement") granting an exclusive license to certain
patents related to Unoprostone (as defined below), and Sucampo Pharma Americas, Inc. subsequently assigned the 2009 License Agreement
to Sucampo AG effective September 30, 2011, which was accepted by R-Tech on September 28, 2011; and

 

Whereas, Sucampo Manufacturing
& Research AG and R-Tech entered into the Exclusive License for Development and Commercialization of Unoprostone dated March
22, 2011 (the “2011 License Agreement”) and Sucampo Manufacturing & Research AG, subsequently as a result of merger
effective May 24, 2011, assigned the 2011 License Agreement to Sucampo AG; and

 

Whereas, Sucampo AG and
R-Tech entered into the Quality Assurance Agreement dated August 23, 2012; and

 

Whereas, Sucampo AG and
R-Tech entered into the Safety Data Exchange Agreement dated May 20, 2013; and

 

Whereas, R-Tech provided
a draft press release which R-Tech subsequently issued on March 9, 2015 that caused Sucampo to advise R-Tech that it would no longer
develop Unoprostone; and

 

Whereas, Sucampo advised
R-Tech in writing on March 9, 2015 that it would return the 2009 License Agreement and 2011 License Agreement (collectively, the
“License Rights”) to R-Tech so that R-Tech could find another partner to develop and commercialize Unoprostone; and

    	 

    	 

    

Whereas, the Parties have
agreed to work together in good faith to terminate the agreements listed above and have the Licensed Rights revert to R-Tech under
the terms of this Transfer and Termination Agreement (“Agreement”) in order to enable R-Tech to further develop and
commercialize Unoprostone.

 

NOW THEREFORE, the Parties agree as follows:

 

		1.	DEFINITIONS

 

All terms used within this Agreement
shall have the meanings set forth below or herein.

 

		1.1.	Action - as defined in Section 6.6 in this Agreement.

 

		1.2.	Affiliates - shall mean an individual, trust, business trust, joint venture, partnership, corporation,
association or any other entity which owns, is owned by or is under common ownership with, a Party to this Agreement. For the purposes
of this definition, the terms "owns" or "owned by" or "under common ownership with" as used with
respect to any Party, shall mean possession (directly or indirectly) of more than fifty percent (50%) of the outstanding voting
securities of a corporation or comparable equity interest in any other type of entity.

 

		1.3.	Agreement - shall mean this License, Transfer, Settlement and Termination Agreement.

 

		1.4.	Applicable laws -shall mean all federal, state, local, national and supra-national laws, statutes,
rules and regulations, including any rules, regulations, or requirements of Regulatory Authorities, major national securities exchanges
or major securities listing organizations, that may be in effect as of the Effective Date, and applicable to particular activities
hereunder.

 

		1.5.	Claims -as set forth in the preamble of this Agreement.

 

		1.6.	Clinical Data - shall mean all data with respect to Unoprostone for all uses that were made, collected
or otherwise generated under or in connection with the clinical studies for Unoprostone for all human uses.

 

		1.7.	CMC Data - means the data contained in the chemistry, manufacturing and controls section of a
submission for Regulatory Approval of the Unoprostone.

 

    	 

    	 

    

		1.8.	Combination Product - means any product in which two or more active ingredients, one of which
is Unoprostone, are physically combined in any type of formulation prior to the therapeutic administration.

 

		1.9.	Development Data - means all Unoprostone-related data, in whatever form it exists, produced or
paid for by Sucampo or its third-party licensees (if any) from the date of the 2009 License Agreement to and including the Effective
Date, including, without limitation all Clinical Data, CMC Data, Pharmacovigilance and Safety Data, and non-clinical Data.

 

		1.10.	Effective Date -as set forth in the title of this Agreement.

 

		1.11.	Licensed Rights -as set forth in the preamble of this Agreement.

 

		1.12.	Sucampo Agreements - together, the 2009 License Agreement and the 2011 License Agreement and all
the exhibits, schedules, and amendments thereto.

 

		1.13.	Sucampo Finished Goods- shall mean all existing finished goods inventory of the Unoprostone held
by Sucampo as of the Effective Date. General information on the inventory of Sucampo Finished Goods and remaining shelf life as
of the Effective Date are attached hereto as Exhibit A.

 

		1.14.	Sucampo Know-How - shall mean, as it relates to Unoprostone, all technology, formulae, trade secrets,
technical data, Development Data, and any other information or experience owned or controlled by Sucampo, if any, and specifically
related to the development, use, or sale of the Unoprostone as well as any improvements or modifications to the know-how developed
by Sucampo, or by any third party for Sucampo, from the date of the 2009 License Agreement through the Effective Date, and which
is not publicly available to any third party prior to the Effective Date.

 

		1.15.	Sucampo Product-Related Intellectual Property - shall mean, as of the Effective Date, wherever
such property or assets exist, all intellectual property owned or controlled by Sucampo and specifically related to the development,
manufacture, use or sale of the Unoprostone if any, including, without limitation, the patents, patent applications, records of
invention, Sucampo Know-How, notebooks, as well as those that may be acquired by Sucampo through the Effective Date. Sucampo Product-Related
Intellectual Property shall include the entire documentation regarding the patents and patent applications, including the original
filing documents and correspondence with the competent patent offices. Under this sub article, all intellectual property including
but not limited to the referenced patents, patent applications, and records of invention as of the Effective Date are listed in
Exhibit B.

 

    	 

    	 

    

		1.16.	Sucampo Product-Related Trade Marks and Domain Names - shall mean, as of the Effective Date, either
owned by Sucampo and/or any of its Affiliates, any trade names, domain names (including, without limitation, website domains and
pages) and copyrights related to RESCULA, which are listed in Exhibit G.

 

		1.17.	Sucampo Product-Related Marketing Materials - shall mean, as of the Effective Date, wherever such
property or assets exist: in written, audio or visual forms, all marketing material, customer and sales information, product literature,
promotional materials and data, advertising and display materials related to the Unoprostone within the Territory which are in
Sucampo's possession and which Sucampo is reasonably able to provide to R-Tech. Without limiting the generality of the definition
set forth in this Section 1.17, the Sucampo Product-Related Marketing Materials are listed in more detail in Exhibit C hereto.

 

		1.18.	Sucampo Third-Party Licenses - shall mean any and all third-party licenses granted by Sucampo
regarding the Unoprostone, the Development Data and the Sucampo Product-Related Intellectual Property. A complete listing and the
terms of such licenses are attached hereto as Exhibit D.

 

		1.19.	2009 License Agreement - as set forth in preamble of this Agreement.

 

		1.20.	2011 License Agreement - as set forth in preamble of this Agreement.

 

		1.21.	Pharmacovigilance or Safety Data Exchange Agreement - as set forth in preamble of this Agreement.

 

		1.22.	Pharmacovigilance and Safety Data - shall mean, as it relates to the Unoprostone, all pharmacovigilance
reports.

 

		1.23.	Medical Affairs Data - shall mean all standard responses to medical information inquiries.

 

		1.24.	Product Complaints – shall mean all information related to product complaints.

 

		1.25.	Quality Agreement – as set forth in the preamble of this Agreement.

 

    	 

    	 

    

		1.26.	Non-clinical Data - shall mean data derived from a study to test the Unoprostone for all uses,
including but not limited to laboratory studies, toxicology, safety, carcinogenicity, pharmacology, disease models and animal models.

 

		1.27.	Regulatory Approval/s - shall mean, as it relates to the Unoprostone, any and all approvals, licenses
(including product licenses), registrations (including registration of trademarks or trade names), or authorizations from any Regulatory
Authority necessary to register, develop, manufacture, commercialize, promote, distribute, transport, store, use, sell or market
the Unoprostone for all uses including the manufacturing license and marketing registration required by any Regulatory Authority,
and pricing approvals, or pre- and post-marketing authorizations, labeling approvals, import or export licenses, technical, medical
and scientific licenses held by Sucampo or any of its licensees or transferees on the Effective Date. As defined under this Section
1.27, all Regulatory Approvals by market in the Territory are listed in Exhibit E to this Agreement.

 

		1.28.	Regulatory Authorities - shall mean, as it relates to the Unoprostone, any national, supra-national,
regional, federal, state, provincial or local regulatory agency, department, bureau, commission, council or other governmental
entity (including, without limitation, any prefecture having jurisdiction over (i) the approval, manufacture, distribution, use,
storage, transport, clinical testing, or sale of the Unoprostone, or (ii) the acceptance, review, approval, and registration of
Regulatory Filings and Documents related to the Unoprostone).

 

		1.29.	Regulatory Filings and Documents - shall mean, as it relates to the Unoprostone, all drug approval
applications, drug master files, and all correspondence submitted to or received from the Regulatory Authorities (including, without
limitation, minutes and official contract reports relating to any communications with any Regulatory Authority) and all supporting
documents (including, without limitation, documents related to past or pending issues with Regulatory Authorities such as inspections
and the related outcomes and findings, clinical statutes and post-approval statutes, and all data contained in any of the foregoing,
including all drug approval applications, adverse event files and product complaint files, including but not limited to, all filings
and documentation regarding regulatory approvals regarding the Unoprostone which had lapsed prior to the Effective Date), provided
such filings and documentation is in Sucampo's possession and Sucampo is reasonably able to provide it to R-Tech.

 

    	 

    	 

    

		1.30.	Sucampo Territory – shall mean worldwide other than Japan, Taiwan, South Korea and People’s
Republic of China.

 

		1.31.	Unoprostone - means the compound also known
by the USAN name of unoprostone isopropyl, which is the composition of matter defined chemically as [...***...],
including all [...***...], as well as any [...***...]
and [...***...] , in any form, [...***...]
and [...***...],
and for any use in any human indication. 

 

		2.	CONSEQUENCES OF TERMINATION

 

		2.1.	Reversion of Licensed Rights to R-Tech.
Subject to the terms and conditions established in this Agreement, Sucampo and R-Tech hereby agree to the full termination of the
Sucampo Agreements. The Parties agree that upon termination of the Sucampo Agreements, all Licensed Rights automatically revert
to R-Tech. For the avoidance of doubt, the Pharmacovigilance Agreement shall remain in full force and effect until the transfer
of the NDA to R-Tech or its designee and thereafter all Pharmacovigilance
responsibilities transfer to R-Tech.

 

		2.2.	Furthermore and subject to the terms of this Agreement, as of the Effective Date:

 

		a.	Transfer of Assets to R-Tech. Sucampo hereby transfers and assigns to R-Tech or its designee:

 

		i.	all Regulatory Approvals and all Regulatory Filings and Documents in the Territory, and

 

		ii.	the Sucampo Product-Related Marketing Materials, subject to Section 2.2 f) below.

 

R-Tech hereby accepts such transfer and assignment.
For the avoidance of doubt, the transfer and assignment includes the exclusive right to use the transferred and assigned information,
data and materials.

 

		b.	Transfer of the Sucampo Product-Related Intellectual Property to R-Tech.

 

	 	i.	Sucampo hereby transfers and assigns to R-Tech, or any other party designated by R-Tech,
the Sucampo Product-Related Intellectual Property. *Confidential Treatment Requested

  

    	 

    	 

    

	 	ii.	Sucampo further covenants not to file suit
against R-Tech and/or its licensees for patent infringement on any R-Tech product or formulation comprising Unoprostone as the
sole active ingredient.

 

		c.	Transfer of Third Party Licenses. Sucampo hereby transfers and assigns to R-Tech, or any
other party designated by R-Tech, all Sucampo Third-Party Licenses; or in the event such license cannot be transferred and assigned
to R-Tech, or any other party designated by R-Tech, Sucampo shall terminate the license agreement-at no cost to R-Tech.

 

		d.	Transfer of Sucampo Product-Related Trade Marks and Domain Names. Sucampo hereby transfers
and assigns, or shall cause its Affiliates to transfer and assign, to R-Tech, or any other party designated by R-Tech, the Sucampo
Product-Related Trade Marks and Domain Names, and R-Tech hereby accepts such assignment.

 

		e.	No Use of RESCULA Trade Mark. Sucampo shall cease all use of the trade mark "RESCULA",
except as required for regulatory or compliance purposes.

 

		f.	No Use of Sucampo Trade Name. R-Tech (including its assignee and sublicensee) may, for
the purpose of its marketing and sale of Unoprostone, use the contents of the packaging and labeling of the Unoprostone consistent
with the Regulatory Approvals. R-Tech shall not have any right to use or any interest in the Sucampo trade name or any Sucampo
proprietary design, system, logo, mark or style.

 

		2.3.	Payment by R-Tech. In consideration
for the transfers and assignments and covenants by Sucampo in accordance with the provisions of Section 2.2, R-Tech shall pay to
Sucampo the sum of US$2,000,000 in the aggregate no later than [...***...]
days subsequent to the Effective Date.

 

		2.4.	Transition Activities. Sucampo shall use commercially reasonable efforts to assist R-Tech
in the transition of the Unoprostone after the Effective Date. Such Obligation to assist shall include, inter alia, the following:

 

		a.	Promptly after the Effective Date, Sucampo shall make available to R-Tech copies of all know how
and other data and documentation regarding the Sucampo

 

*Confidential Treatment Requested

 

    	 

    	 

    

		b.	Know-How and the Sucampo Product-Related Marketing Materials as laid out in the matrix in Exhibit
F hereto;

 

		c.	Sucampo shall promptly return to R-Tech, or any other party designated by R-Tech or, at R-Tech's
option, destroy, at Sucampo's expense, all records and copies of any Confidential Information of R-Tech and all copies thereof,
except where Sucampo shall be required by Applicable Laws or Sucampo internal procedures to maintain copies for archiving purpose
only;

 

		d.	Sucampo shall promptly destroy, at Sucampo's expense, all Sucampo Finished Goods with an expiration
of less than one year;

 

		e.	Following R-Tech's initiation, drafting, set-up and execution of the necessary documents to perform
the activities described in this Section 2.4, Sucampo shall use its commercial reasonable efforts to execute such documents;

 

		f.	Where permitted, Sucampo shall assign to R-Tech, or any other party designated by R-Tech, free
of charge by Sucampo, all agreements with third-party distributors, or in the event such agreement cannot be assigned to R-Tech,
or any other party designated by R-Tech, Sucampo shall terminate the agreement at the instructions of R-Tech without cost to R-Tech
and for such interim period until termination of the agreements, Sucampo shall exercise its rights under the agreements with third
party distributors at the direction and for the benefit of R-Tech.

 

		2.5.	Mutual Release. Subject to Article 6 below, each Party hereby releases, exonerates and forever
and unconditionally discharges the other Party and all its Affiliates, transferees, representatives, principals, agents, officers,
directors, employees, staff and third-party consultants from any and all liability new or hereafter arising directly or indirectly
out of the Claims or the Sucampo Agreements. Termination of the Sucampo Agreements shall be without prejudice to any right which
shall have accrued to either Party thereunder prior to such termination.

 

		2.6.	Establishment License Fee.

 

No
later than [...***...] to the Effective Date, R-Tech shall
reimburse Sucampo for the Establishment License Fee in relation to the NittoMedic facility (i.e., $600,313.26) 

 

*Confidential Treatment Requested

 

 

    	 

    	 

    

which Sucampo, as the NDA holder, already paid
to FDA but has requested FDA for refund on the condition that there will be no manufacture of RESCULA® for the 2014FY; provided,
however, that Sucampo shall immediately return the said reimbursement to R-Tech if and to the extent it for any reason receives
any refund from FDA.

 

		3.	TRANSITION ACTIVITIES AND RESPONSIBILITIES

 

		3.1.	The Parties shall use commercially reasonable efforts to ensure that as soon as practicable and
legally feasible after the Effective Date:

 

		a.	Perform the transition activities set forth in Section 2.4 above and Exhibit F;

 

		b.	Regulatory Approvals are transferred to
R-Tech. All transition activities related to the Regulatory Approvals must be initiated by R-Tech within [...***...]
after the Effective Date. For the avoidance of doubt, Sucampo shall not
be obliged to assist R-Tech in any activities relating to the transfer of Regulatory Approvals if such activity is initiated by
R-Tech after [...***...] from the Effective Date

 

		3.2.	From the Effective Date and for a reasonable
time period thereafter (but in no case more than [...***...],
the Parties agree to work together in good faith to complete the general transition activities as these are laid out in the matrix
set forth in Exhibit F to this Agreement. The matrix shall outline the expectations for each Party's compliance under this Agreement
and shall include, at minimum: a required list of actions and the related schedule, roles and responsibilities, and process monitoring
and validation. Furthermore, Sucampo shall use commercially reasonable efforts to assist R-Tech or any other party designated by
R-Tech in the transfer of technology and assets as set forth above and in taking over the development, manufacture, marketing and
sale of the Unoprostone.

 

		3.3.	Sucampo will provide the assistance under
this Article 3 during the [...***...] after the Effective
Date cost free and thereafter R-Tech shall reimburse Sucampo's reasonable expenses at Sucampo's standard FTE rate for corresponding
services.

 

		4.	CONFIDENTIALITY

 

		4.1.	The Parties agree:

 

*Confidential Treatment Requested

 

    	 

    	 

    

not to disclose or otherwise make available to
any third party any information that is treated as confidential by the disclosing Party, including, without limitation, trade secrets,
technology, information pertaining to business operations and strategies, and information pertaining to customers, pricing, and
marketing (collectively, the "Confidential Information") without the prior written consent of the disclosing party; provided,
however, that the receiving Party may disclose the Confidential Information to its officers, employees, consultants and legal advisors
who have a "need to know", who have been apprised of this restriction and who are themselves bound by nondisclosure restrictions
at least as restrictive as those set forth in this Article 4;

 

		a.	to use the Confidential Information as permitted under and only for the purpose of performing
the respective obligations under this Agreement;

 

		b.	to immediately notify the disclosing Party in the event it becomes aware of any loss or disclosure
of any Confidential Information.

 

		4.2.	Confidential Information shall not include information of which the receiving Party can show that:

 

		a.	it is already known to the receiving Party without restriction on use or disclosure prior to receipt
of such information from the disclosing Party;

 

		b.	it is or becomes generally known by the public other than by breach of this Agreement by, or other
wrongful act of, the receiving Party;

 

		c.	it is received by the receiving Party from a third party who is not under any obligation to the
disclosing Party to maintain the confidentiality of such information; or

 

		d.	such disclosures is required by Applicable
Laws, in which case the receiving Party shall provide the disclosing Party with at least [...***...] prior
written notice of such disclosure so that the disclosing Party shall have the opportunity if it so desires to seek a protective
order or other appropriate remedy and, in connection with any such required disclosure, the receiving Party shall use reasonable
efforts to obtain confidential treatment for such disclosure or to prevent or 

 

*Confidential Treatment Requested

 

    	 

    	 

    

		e.	modify such disclosure as may be requested by the disclosing Party (to the extent permitted by
Applicable Law).

 

		4.3.	It shall be the obligation of the receiving Party to prove that such an exception to the definition
of the Confidential Information exists.

 

		4.4.	Sucampo Know-How and all Development Data and other records transferred from Sucampo to R-Tech
hereunder are Confidential Information of R-Tech for the purposes of this Article 4.

 

		4.5.	Both Parties shall have the right to publish
press releases which it deems material or necessary to meet its obligations under Applicable Laws. With respect to any press release
relating to this Agreement, each Party shall give [...***...] prior
written notice to the other Party prior to issuing a press release and shall give due consideration and weight to any comments
or concerns raised by the other Party. Such [...***...] day
period may be reduced only in good faith, for legal reasons and after providing to the other party with clear evidence of such
time limitation. In any case, the minimum previous notice to be provided to any other Party under such circumstances shall be not
less than [...***...] days. Either Party may disclose the
terms of this Agreement to its existing or potential investors, lenders, collaborative partners or, in the case of a change of
control, acquires as part of their due diligence investigations, provided, however, that such existing investors, lenders, collaborative
partners or acquirers have agreed to maintain the confidentiality of the terms of this Agreement and to use such information solely
for the purpose of such due diligence investigation.

 

		5.	REPRESENTATIONS, WARRANTIES AND COVENANTS

 

		5.1.	Each Party represents and warrants to the other Party that:

 

		a.	it is duly organized, validly existing and in good standing as a corporation or other entity as represented herein under the
laws and regulations of its jurisdiction of incorporation, organization or chartering;

 

		b.	it has the full right, power and authority to enter into this Agreement, to grant the rights and licenses granted hereunder
and to perform its obligations

 

*Confidential Treatment Requested

 

    	 

    	 

    

		c.	hereunder, and (ii) the execution of this Agreement by its representative whose signature is set forth at the end hereof has
been duly authorized by all necessary corporate action of the Party;

 

		d.	when executed and delivered by such Party, this Agreement will constitute the legal, valid and binding obligation of such Party,
enforceable against such Party in accordance with its terms; and

 

		e.	the execution and delivery of this Agreement by such Party, the performance by such Party of its obligations hereunder and
the consummation by such Party of the transactions contemplated hereby: (i) will not conflict with, result in a breach or violation
of, or constitute a default under any law, rule, regulation, order, judgment, injunction, decree, determination or award currently
in effect applicable to such Party; and (ii) will not conflict with, result in a breach or violation of, or constitute a default
under any agreement to which such Party is a party.

 

		5.2.	Further, Sucampo represents and warrants to R-Tech that, as of the Effective
Date, and to the best of its knowledge, it has disclosed to R-Tech the material existence of i) all Sucampo Product-Related Marketing
Materials, (ii) all Sucampo Product-Related Intellectual Property, (iii) Regulatory Filing and Documents, (iv) Development Data,
(v) Regulatory Approvals, (vi) Sucampo Finished Goods, and (vii) all Sucampo Third-Party Licenses. Furthermore, Sucampo warrants
that, to the best of its knowledge, there are no [...***...]
or [...***...] directly related to the [...***...]
or [...***...]
of the [...***...].

 

		5.3.	Sucampo further represents and warrants to R-Tech that, as of the Effective Date, there is no action, cause of action, suit,
claim, complaint, demand, litigation or legal, administrative or arbitral proceedings or investigation pending or threatened against
or involving Sucampo or, to the best of its knowledge, third-party licensees under the Sucampo Third-Party Licenses in relation
to any of those to be transferred to R-Tech pursuant to the provisions of Article 2 of this Agreement.

 

*Confidential Treatment Requested

 

    	 

    	 

    

 

		5.4.	For the avoidance of doubt, Sucampo does not warrant and shall not be responsible for the successful registration, maintenance
and/or renewal of the Regulatory Approvals after the Effective Date.

 

		5.5.	Except as provided in this Article 5 or as provided for in this Agreement, Sucampo makes no representations, extends no warranties
of any kind, either express or implied, and assumes no responsibility after the Effective Date whatsoever in respect of the Unoprostone
and the Sucampo Product-Related Intellectual Property.

 

		6.	LIABILITIES AND INDEMNITIES

 

		6.1.	Sucampo shall retain responsibility for all risks and liabilities in any way related to the Unoprostone
and the related Regulatory Approvals in all countries of the Territory where Sucampo held such approvals or distributed RESCULA
prior to the Effective Date.

 

		6.2.	Sucampo agrees to indemnify, save, defend and hold R-Tech and sub-licensees, and its respective
officers, directors, agents and employees harmless from and against any and all claims, demands, liabilities, damages and expenses,
including reasonable attorneys' fees and costs incurred by R-Tech in any way related to: a) the Unoprostone sold by Sucampo, third-party
licensees or its agents in the Territory prior to the Effective Date; b) Sucampo Product-Related Intellectual Property and Sucampo
Product-Related Marketing Materials used by Sucampo and its Affiliates in the Territory and arising prior to the Effective Date;
c) Sucampo Third-Party Licenses prior to any transfer or assignment pursuant to this Agreement; and d) any material breach by Sucampo
of the representations and warranties made by it herein;

 

		6.3.	R-Tech shall assume all responsibility for all risks and liabilities directly related to the R-Tech's
manufacture, marketing, promotion, sale, distribution or supply of Unoprostone and its use of Sucampo Product-Related Intellectual
Property and Sucampo Product-Related Marketing Materials in the Territory after the Effective Date.

 

		6.4.	R-Tech shall indemnify, save, defend and hold harmless Sucampo and sub-licensees, and its respective
officers, directors, agents and employees harmless from and against any and all claims, demands, liabilities, damages and expenses,

 

*Confidential Treatment Requested

 

    	 

    	 

    

 

including reasonable attorneys' fees and costs
in respect of any claims for loss, damage or injury incurred by Sucampo relating to: a) Unoprostone sold by R-Tech in the Territory
after the Effective Date; b) R-Tech's use of, or actions regarding, the Sucampo Product-Related Intellectual Property and the Sucampo
Product-Related Marketing Materials after the Effective Date.

 

		6.5.	Neither Party shall be liable for any loss of profits or any consequential, indirect or special
loss, damage or injury of any kind suffered by the other Party.

 

		6.6.	The indemnified Party shall promptly notify the indemnifying Party in writing of any third Party
claim, suit, action or proceeding (each, an "Action") and cooperate with the indemnifying Party at the indemnifying Party's
sole cost and expense. The indemnifying Party shall immediately take control of the defense and investigation of such Action and
shall employ counsel of its choice to handle and defend the same, at the indemnifying Party's sole cost and expense. The indemnifying
Party shall not settle any Action in a manner that adversely affects the rights of the indemnified Party without the indemnified
Party's prior written consent, which shall not be unreasonably withheld or delayed. The indemnified Party's failure to perform
any obligations under this Section 6.6 shall not relieve the indemnifying Party of its obligations under this Section 6.6 except
to the extent that the indemnifying Party can demonstrate that it has been materially prejudiced as a result of such failure. The
indemnified Party may participate in and observe the proceedings at its own cost and expense.

 

		7.	RECALLS AND RETURNS

 

		7.1.	Subject to Article 6 (Liabilities and Indemnities), Sucampo shall be financially
responsible for all returns of all RESCULA sold by it or on its behalf in the Territory prior to the Effective Date.

 

		7.2.	Subject to Article 6 (Liabilities and Indemnities), R-Tech shall be financially
responsible for all returns of all RESCULA sold by it or on its behalf in the Territory from and after the Effective Date.

 

		7.3.	Subject to Article 6 (Liabilities and Indemnities), Sucampo shall be responsible,
at its expense for any and all recalls of any and all formulations of RESCULA manufactured or sold by it or on its behalf in the
Territory prior to the Effective Date.

 

    	 

    	 

    

		7.4.	Subject to Article 6 (Liabilities and Indemnities), R-Tech shall be responsible,
at its expense, for any and all recalls of any and all formulations of Unoprostone manufactured or sold by it or on its behalf
in the Territory from and after the Effective Date.

 

		8.	ASSIGNMENT

 

Neither Party may assign,
license or sublicense the rights and obligations under this Agreement or under the Sucampo Agreements. Any attempted assignment,
transfer or other conveyance in violation of the foregoing shall be null and void.

 

		9.	TERM AND TERMINATION

 

This Agreement shall commence
as of the Effective Date.

 

		10.	MISCELLANEOUS

 

		10.1.	Survival. Any rights or obligations of the Parties in this Agreement which, by their nature, should
survive the termination or expiration of this Agreement shall survive, including the applicable rights and obligation set forth
in this Section 10.1 and Article 1 (DEFINITIONS), Article 2 (CONSEQUENCES OF TERMINATION), Article 3 (TRANSITION ACTIVITIES AND
RESPONSIBILITIES), Article 4 (CONFIDENTIALITY), Article 5 (REPRESENTATIONS, WARRANTIES AND COVENANTS), Article 6 (LIABILITIES AND
INDEMNITIES), Article 7 (RECALLS AND RETURNS), Article 8 (ASSIGNMENT), Article 9 (TERM AND TERMINATION), and Article 10 (MISCELLANEOUS).

 

		10.2.	Severance. In the event that any clause or any part of any clause in this Agreement is declared
invalid or unenforceable by the judgment or decree by consent or otherwise of a court of competent jurisdiction from whose decision
no appeal is or can be taken, all other clauses or parts of clauses contained in this Agreement shall remain in full force and
effect and shall not be affected by such finding for the term of this Agreement.

 

		10.3.	No Waiver. No relaxation, forbearance, delay or indulgence by either Party in enforcing any of
the terms and conditions of this Agreement or the granting of the terms and conditions of this Agreement or the granting of time
by either Party to the other shall prejudice, affect or restrict the rights and powers of the said Party nor shall any waiver by
either Party of any breach of this Agreement operate as a waiver of or in relation to any subsequent or any continuing breach of
it.

 

    	 

    	 

    

		10.4.	Variation. This Agreement may be amended only by a document in writing signed by a duly authorized
officer of each Party.

 

		10.5.	Further Assurance. The Parties shall execute all further documents as may be necessary or desirable
to give full effect to the terms of this Agreement and to protect the rights of the Parties under it.

 

		10.6.	Entire Agreement. This Agreement and the documents referred to in it, constitute the entire agreement
and understanding of the Parties and supersedes any previous agreement, written or oral, between the Parties relating to the subject
matter of this Agreement.

 

		10.7.	Remedy. Each of the Parties acknowledges and agrees that in entering into this Agreement, and
the documents referred to in it, it does not rely on, and shall have no remedy in respect of, any statement, representation, warranty
or understanding (whether negligently or innocently made) of any person (whether Party to this Agreement or not) other than as
expressly set out in this Agreement as a warranty or representation. The only remedy available to it for breach of such warranties
or representations shall be for breach of contract under the terms of this Agreement. Nothing in this clause shall, however, operate
to limit or exclude any liability for fraud.

 

		10.8.	Notice. Any notice or other document to be given under this Agreement shall be given by sending
the same in a pre-paid first class letter or by PDF attached to email with a return and read receipt notification to the address
of the relevant Party set out in this Agreement, or to such other address as such Party may have notified to the other for such
purposes. Any notice sent by post shall be deemed (in the absence of evidence of earlier receipt) to have been delivered fourteen
(14) days after dispatch and in proving the fact of dispatch it shall be sufficient to show that the envelope containing such notice
was properly addressed, stamped and posted. Any notice sent by fax shall be deemed to have been delivered on the day following
its dispatch.

 

    	 

    	 

    

	 	If to R-Tech:	 	R-Tech
Ueno, Ltd.
	 	 	 	10F, NBF Hibiya Building 1-1-7, Uchisaiwaicho

Chiyoda-ku, Tokyo 100-0011 Japan

Facsimile:[...***...]

Attention: Office of the President

	 	 	 	 
	 	If to Sucampo:	 	Sucampo
AG
	 	 	 	Baarerstrasse 22

6300 Zug Switzerland

Facsimile:

Attention: Secretary

 

	A copy to:	 	Sucampo Pharma Americas, LLC
	 	 	 	 	4520 East West Highway, 3rd Flr.

Bethesda, MD 20814

Facsimile:
[...***...]

Attn: General Counsel

 

 

 

*Confidential Treatment Requested

 

 

 

    	 

    	 

    

		10.9.	Governing Law. This Agreement and any disputes of claims arising out of or in connection with
its subject matter are governed by and construed in accordance with the law of Switzerland.

 

		10.10.	Jurisdiction. The Parties irrevocably agree that the courts of the state of New York shall have
exclusive jurisdiction to settle any dispute or claim that arises out of or in connection with this Agreement.

 

 

-Signature page follows -

 

 

 

    	 

    	 

    

 

IN WITNESS WHEREOF, the Parties
hereto have caused this Agreement to be executed in duplicate counterparts by their duly authorized representatives, each fully
executed copy hereof to be deemed as original, as of the Effective Date.

 

 

	R-Tech Ueno, Ltd.	 	Sucampo AG
	 	 	 	 	 
	 	 	 	 	 
	 	 	 	 	 
	By:	/s/ Yukihiko Mashima	 	By:	/s/ Peter
Greenleaf

	Name:	Yukihiko Mashima	 	Name:	Peter
S. Greenleaf
	Title:	President	 	Title:	President
	Date:	May 1, 2015	 	Date:	May 4, 2015

 

 

 

 

 

    	 

    	 

    

List of Exhibits:

Exhibit A - Sucampo Finished Goods as set forth in
Section 1.13 above.

Exhibit B - Sucampo patents under the Sucampo Product-Related
Intellectual Property as set forth in Section 1.15 above.

Exhibit C - Sucampo Product-Related Marketing Materials
as set forth in Section 1.17 above.

Exhibit D - Sucampo Product-Related Third-Party Licenses
as set forth in Section 1.18 above.

Exhibit E - Sucampo Regulatory Approvals by Market
as set forth in Section 1.27 above.

Exhibit F - Transition activities and responsibilities
matrix as set forth in Section 2.4 above.

Exhibit G - Sucampo Product Related Trade Names and
Domain Names in Section 1.16 above.

 

    	 

    	 

    

 

Exhibit A - Sucampo Finished
Goods as set forth in Section 1.13 above.

 

 

NONE

 

 

    	 

    	 

    

 

Exhibit B - Sucampo patents
under the Sucampo Product-Related Intellectual Property as set forth in Section 1.15 above.

	File No.	Title	Country	Application No.	Filing Date	Publication No.	Publication Date	Patent No.	Issue Date	Exclusivity Ends	Status
	[...***...]	[...***...]	[...***...]	[...***...]	[...***...]	[...***...]	[...***...]	[...***...]	[...***...]	[...***...]	[...***...]

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

*Confidential Treatment Requested

    	 

    	 

    

 

Exhibit C - Sucampo Product-Related
Marketing Materials as set forth in Section 1.17 above.

	File No.	Trade Mark	Country	Class	Appl. No.	Appl. Date	Pub No.	Pub Date	Regist. No. 	Regist Date	Status	Next renewal	Notes
	[...***...]	[...***...]	[...***...]	[...***...]	[...***...]	[...***...]	[...***...]	[...***...]	[...***...]	[...***...]	[...***...]	[...***...]	[...***...]

 

 

 

Rescula Promotional Materials submitted to the Office of
Prescription Drug Promotion, FDA

	Material Type

(FDA codes)	Material ID Code and/or Description	Date Submitted to OPDP	Dissemination/ Publication Date
	[...***...]	[...***...]	[...***...]	[...***...]

 

*Confidential Treatment Requested

    	 

    	 

    

Exhibit D - Sucampo Product-Related
Third-Party Licenses as set forth in

Section 1.18 above.

 

 

NONE

 

 

 

    	 

    	 

    

Exhibit E - Sucampo Regulatory
Approvals by Market as set forth in Section 1.27 above.

 

United States of America IND

IND holder: Sucampo Pharma Americas LLC, Bethesda

IND number: 51,790

IND date: effective 24 November 1996 (IND transferred to SPA
from RTU on 16 July 2009)

Tradename: N/A

Strength: 0.15%

Indication: Reduction of Intraocular Pressure in Open-Angle
Glaucoma or Ocular Hypertension

 

United States of America NDA

MA holder: Sucampo Pharma Americas LLC, Bethesda

MA number: NDA 21214

MA date: approved 3 August 2000 (NDA transferred to SPA from
RTU on 16 July 2009)

Tradename: RESCULA

Strength: 0.15%

Indication: Reduction of Intraocular Pressure in Open-Angle
Glaucoma or Ocular Hypertension

 

United States of America Orphan Drug Designation (ODD)

ODD holder: Sucampo Pharma Americas LLC, Bethesda

ODD number: 10-3148

ODD granted date: 16 September 2010

Tradename: RESCULA

Strength: 0.15%

Indication: Retinitis Pigmentosa

 

European Union Orphan Drug Designation (ODD)

ODD holder: Sucampo Pharma Europe Ltd., Abingdon

ODD number: EMA/OD/067/13

ODD date: 19 June 2013

INN: Unoprostone isopropyl

Pharmaceutical form: solution for ophthalmic use (eye drops)

Indication: Retinitis Pigmentosa

 

    	 

    	 

    

Exhibit F - Transition
Activities and Responsibilities Matrix as set forth in Section 2.4 above

		1.	Roles and responsibilities

 

	Roles	Contact Person
	[...***...]	[...***...]

Responsibilities: Subject to Article 3 and Article
5 in this Agreement

		2.	Description of process of materials, files and documents to be transferred

	Action	Content
	Sucampo	
        Provide
        the inventory list of all electronic and paper materials, files, and documents to be transferred to R-Tech within [...***...]
        of Effective Date.

         

	R-Tech	
        Respond
        to inventory list within ([...***...])[...***...]
        of receipt by R-Tech. If R-Tech needs an explanation of any item on the
        inventory list, R-Tech shall notify Sucampo within ([...***...])[...***...]
        after receipt of the inventory list. Sucampo shall respond to R-Tech within
        ([...***...]) [...***...] days
        of receipt of the notification.

         

	Sucampo	
        Transfer
        all the materials, files and documents to the location and by the means specified by R-Tech within the later of [...***...]
        of receipt of inventory list by R-Tech or the receipt of Sucampo response to R-Tech’s request for further explanation.

         

	R-Tech	
        Confirmation
        of receipt of transfer of inventory. R-Tech shall provide Sucampo notification of any missing inventory within [...***...]
        of confirmation. Sucampo shall provide its response and missing inventory
        within [...***...] of receipt of notification by R-Tech.

         

 

		3.	Inventory list/documents for delivery by Sucampo

 

		3.1.	List of regulatory materials, files and documents from Sucampo

 

		a.	A list of all Regulatory Filings and Documents by country

 

*Confidential Treatment Requested

 

 

    	 

    	 

    

		b.	A summary and explanation of any files (electronic and paper), language of dossier, the necessity
for annual maintenance, regulatory status, and the procedure for succession and transfer of ownership of regulatory filings.

 

		3.2.	PVG related list of materials from Sucampo

 

		3.3.	A reconciliation of the PVG data through exchange of listings.

 

		4.	Points to be covered on a country-by- country basis

 

		4.1.	Birthdates are being used for PSUR filings - country or international.

 

		4.2.	Reporting language.

 

		4.3.	The date of the next PSUR filing due.

 

		5.	Process monitoring and validation

 

R-Tech (and/or its agent) and Sucampo will develop
and share a RESCULA Transition Status file (Excel file) summarizing the schedule and status of all transition activities, which
will be used to monitor the transfer.

 

 

 

 

 

 

 

 

    	 

    	 

    

Exhibit G - Sucampo Product-Related
Trade Marks and Domain Names as set forth in Section 1.16

	
        Domain Name

        	
         Registry Expiration
	Current Registered Party
	[...***...]	[...***...]	[...***...]
	[...***...]	[...***...]	[...***...]
	[...***...]	[...***...]	[...***...]
	[...***...]	[...***...]	[...***...]
	[...***...]	[...***...]	[...***...]
	[...***...]	[...***...]	[...***...]
	[...***...]	[...***...]	[...***...]
	[...***...]	[...***...]	[...***...]
	[...***...]	[...***...]	[...***...]
	[...***...]	[...***...]	[...***...]
	[...***...]	[...***...]	[...***...]
	[...***...]	[...***...]	[...***...]

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

*Confidential Treatment RequestedWEC EG 06.30.2015 EX 10.1

Exhibit 10.1

WEC ENERGY GROUP, INC.
TERMS AND CONDITIONS FOR JULY 31, 2015 
SPECIAL RESTRICTED STOCK AWARD

		
	1.
	AWARD

Subject to the terms, conditions and restrictions provided in the Notice of Restricted Stock Award (the “Notice”), this Stock Award and the Plan, WEC Energy Group, Inc. (f/k/a Wisconsin Energy Corporation) (the “Company”) grants to the Employee a restricted stock award pursuant to the Wisconsin Energy Corporation Omnibus Stock Incentive Plan as amended and restated effective as of May 5, 2011 (the “Plan”).  The Stock Award covers a number of shares of the common stock of the Company, as set forth in the Notice, effective as of the date set forth in the Notice (the “Award Date”).  The shares granted under the Stock Award shall be referred to as “Restricted Stock.”  
		
	2.
	RESTRICTED PERIOD; VESTING

		
	(a)
	Restricted Period.  During the period beginning on the Award Date and ending on the day before the third anniversary of the Award Date (the “Restricted Period”), to the extent that all or any portion of the Stock Award is not vested, the Employee may not sell, transfer, pledge, assign, or otherwise alienate or hypothecate, voluntarily or involuntarily, shares covered by the non-vested portion of the Stock Award, except by will or the laws of descent and distribution.  As the Stock Award vests in accordance with subsection 2(b), the vested portion of the Stock Award shall be free of the foregoing restrictions.

		
	(b)
	Vesting.  As long as the Employee remains an employee of the Company or its subsidiaries, the Stock Award will vest over the Restricted Period in accordance with the following schedule:

	
		
	Vesting Date
	% of Shares Becoming Vested (rounded to the nearest whole share)

	January 29, 2016
	33.33%

	January 31, 2017
	33.33%

	July 31, 2018
	33.34%

No termination of employment shall be deemed to have occurred by reason of a transfer of the Employee between the Company and a subsidiary or between two subsidiaries.
		
	(c)
	Notwithstanding subsection 2(b), the following provisions shall govern:

		
	(i)
	Termination due to Death or Disability; Occurrence of Change in Control.  If, during the Restricted Period, (A) the Employee’s employment with the Company and its subsidiaries terminates by reason of the Employee’s disability or death or (B) a Change in Control (as defined in paragraph 14 of the Plan), any unvested portion of the Stock Award shall become fully vested with respect to all shares covered by the Stock Award and all transfer restrictions shall lapse.  For purposes of the foregoing, “disability” shall mean separation from the service of the Company or a subsidiary because of such illness or injury as renders the Employee unable to perform the material duties of the Employee’s job.  

		
	(ii)
	Other Termination.  If the Employee’s employment terminates for any reason other than those described in paragraph (i) during the Restricted Period (excluding transfers as noted under subsection 2(b)), the Employee shall forfeit all shares covered by the unvested portion of the Stock Award (determined above in subsection 2(b)) as of the date of such termination, without any further obligation of the Company to the Employee and all rights of the Employee with respect to such Restricted Stock shall terminate.  Notwithstanding the foregoing, the Compensation Committee may, in its discretion, vest shares upon the Employee’s termination from employment.

		
	3.
	RIGHTS DURING RESTRICTED PERIOD

The Employee, during the Restricted Period, shall have the right to vote the Restricted Stock and receive any dividends on the Restricted Stock.  Any dividends declared on the Restricted Stock shall be paid to Employee through payroll.  Such dividends shall not be subject to the vesting schedule or any other restrictions as exist regarding the original shares of Restricted Stock. 
		
	4.
	CUSTODY

The Restricted Stock may be credited to the Employee in book entry form and shall be held in custody by the Company or an agent for the Company until the applicable restrictions have expired.  If any certificates are issued for shares of Restricted Stock during the Restricted Period, such certificates shall bear an appropriate legend as determined by the Company referring to the applicable terms, conditions and restrictions and the Employee shall deliver a signed, blank stock power to the Company relating thereto.  
		
	5.
	TAX WITHHOLDING

The Company shall be entitled to withhold the amount of any tax attributable to the Stock Award by withholding a portion of shares to defray all or a portion of any applicable taxes, withholding the required amounts from other compensation payable to the Employee, or by such other method determined by the Committee (including, but not limited to, requiring a cash payment by Employee to the Company), in its discretion. 
		
	6.
	IMPACT ON OTHER BENEFITS

The value of the Restricted Stock awarded hereunder, either on the Award Date or at the time such shares become vested, shall not be includable as compensation or earnings for purposes of any other benefit plan or program offered by the Company or its subsidiaries.
		
	7.
	REGISTRATION

		
	(a)
	Any shares issued pursuant to the Stock Award hereunder shall be shares that are listed for trading on a national securities exchange and registered under the Securities Act of 1933, as amended.  The Company does not have an obligation to sell or issue shares that are not so registered.  In the event that shares are not effectively registered, but can be issued by virtue of an exemption under the Securities Act of 1933, as amended, the Company may issue shares to the Employee if the Employee represents that such shares are being acquired as an investment and not with a view to, or for sale in connection with, the distribution of any such shares.  Certificates for shares issued under the circumstances of the preceding sentence shall bear an appropriate legend reciting such representation.

		
	(b)
	In no event shall the Company be required to sell, issue or deliver shares pursuant to this Stock Award if, in the opinion of the Committee, the issuance thereof would constitute a violation by either the Employee or the Company of any provision of any law or regulation of any governmental authority or any securities exchange.  As a condition of any sale or issuance of shares deliverable under the Stock Award, the Company may place legends on the shares, issue stop-transfer orders and require such agreements or undertakings from the Employee as the Company may deem necessary or advisable to assure compliance with any such law or regulation.

		
	8.
	PLAN GOVERNS

Notwithstanding anything in this Stock Award, the terms of this Stock Award shall be subject to the provisions of the Plan, a copy of which is available electronically through the website of the broker servicing the Plan or may otherwise be obtained from a member of the Executive Compensation & Benefits staff.  This Award is subject to all interpretations, amendments, rules and regulations established by the Compensation Committee from time to time pursuant to the Plan.  In the event of an express conflict between any term, provision or condition of this Stock Award and those of the Plan, the terms, provisions or conditions of the Plan shall control.  Any term, condition or provision on which the Award is silent shall be governed and administered in accordance with the terms, conditions or provisions of the Plan.  

		
	9.
	No Employment Rights 

Nothing in this Stock Award shall confer upon the Employee the right to continue in the employ of the Company or any of its subsidiaries, or to interfere with or limit the right of the Company or of such subsidiary to terminate the Employee’s employment at any time.
		
	10.
	Undertaking by Employee

The Employee hereby agrees to take whatever additional actions and execute whatever additional documents the Compensation Committee may, in its discretion, deem necessary or advisable in order to carry out or effect one or more of the obligations or restrictions imposed on the Employee pursuant to the express provisions of this Stock Award and the Plan.
		
	11.
	Binding Effect

This Award shall be binding upon, and inure to the benefit of, the successors and assigns of the Company and upon persons who acquire the right to receive shares covered by the Stock Award hereunder by will or through the laws of descent and distribution.
		
	12.
	Headings

Headings of the paragraphs contained in this Stock Award are inserted for convenience and reference and shall not be used in interpreting or construing the terms and provisions of the Award.
		
	13.
	Entire Award; Modification

This Award and the Plan constitutes the entire agreement between the parties with respect to the terms and supersede all prior or written or oral negotiations, commitments, representations and agreements with respect thereto.  The terms and conditions set forth in this Stock Award may only be modified or amended in a writing, signed by both parties. 
		
	14.
	Severability

In the event any one or more of the provisions of this Stock Award shall be held invalid, illegal or unenforceable in any respect in any jurisdiction, such provision or provisions shall be automatically deemed amended, but only to the extent necessary to render such provision or provisions valid, legal and enforceable in such jurisdiction, and the validity, legality and enforceability of the remaining provisions of this Stock Award shall not in any way be affected or impaired thereby.
*    *    *

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