Document:

Exhibit 10.31

 

CONFIDENTIAL TREATMENT REQUESTED

 

INFORMATION FOR WHICH CONFIDENTIAL TREATMENT HAS BEEN REQUESTED IS OMITTED AND NOTED WITH “****”.

AN UNREDACTED VERSION OF THIS DOCUMENT HAS ALSO BEEN PROVIDED TO THE SECURITIES AND EXCHANGE COMMISSION.

 

AMENDMENT NO. 3 TO THE AGREEMENT CONCERNING CARDIOLITE® AND
 TECHNELITE® GENERATOR SUPPLY, PRICING AND REBATES

 

This Amendment No. 3 (the “Amendment”) to the Agreement Concerning Cardiolite® and Technelite® Generator Supply, Pricing and Rebates dated as of February 1, 2008 (the “Agreement”) is made by and between Lantheus Medical Imaging, Inc., with its principal place of business at 331 Treble Cove Road, North Billerica, Massachusetts 01862 (“Medical Imaging”), and United Pharmacy Partners, Inc., with its principal place of business at 5400 Laurel Springs Parkway, Suite 405, Suwanee, GA 30024 (“UPPI”), and is effective as of May 1, 2009. (the “Effective Date”)

 

RECITALS

 

WHEREAS, Medical Imaging and UPPI are parties to the Agreement and desire  to further amend the Agreement, as provided herein;

 

NOW, THEREFORE, in consideration of the premises and agreements set forth in this Amendment and intending to be legally bound, Medical Imaging and UPPI hereby agree as follows:

 

AMENDMENT

 

1.     Section I. - Section I. Defined Terms is amended by deleting such section in its entirety and replacing therewith the following:

 

“1.   Defined Terms

 

A.            Capitalized terms not otherwise defined herein shall have the meanings specified in the Standard Cardiolite® Terms.

 

B.            “Agreements” means collectively the Agreement, as in effect from time to time, the Individual Pharmacy Agreement, and the Standard Cardiolite® Terms.

 

C.            “Approved” means Approved by the United States Food and Drug Administration pursuant to an Abbreviated New Drug Application as a Sestamibi Product.

 

D.            “Cardiolite® Reference Month” means for Cardiolite® pricing in any then-current calendar month, the calendar month **** months prior to such then-current calendar month (e.g., June has **** as a Reference Month, July has **** as a reference month and so on). For the purposes hereof, the first Cardiolite® Reference Month is ****.

 

E.             “Fee Per Dose” means the purchase price per dose of Cardiolite® set forth on Exhibit 1, attached hereto, as such price may be modified from time to time in accordance with the Agreements.

 

F.             “Good Standing” means the status of having obtained and retained all federal, state and local licenses and other requirements necessary for the lawful conduct of 

 

 

business as a commercial radiopharmacy.

 

G.            “Individual Pharmacy Agreements” means the Cardiolite® License and Supply Agreements between Medical Imaging and a Member.

 

H.            “Member” means a Member of UPPI in Good Standing.

 

I.              “Radiopharmaceutical Reference Month” means for Technelite® and Thallium pricing, in any then-current calendar month, is the immediately preceding calendar month. For the purposes hereof, the first Radiopharmaceutical Reference Month will be May 2009.

 

J.             “Technelite® Generator Purchase Price” means the purchase price for Technelite® Generators set forth in Exhibit 1, attached hereto, as such price may be modified from time to time.

 

K.            “Technelite® Generators” means technetium Tc99m generators sold under the trademark Technelite®.

 

L.             “Technelite® Generator Unshipped Curies” means the number of curies that are not shipped if a Technelite® Generator order, accepted by Medical Imaging, is not filled as ordered resulting in no shipment or a shipment of fewer curies than originally specified on the order.

 

2.     Section II. A. Section II. A, “Pricing”, is amended by deleting such section in its entirety and replace therewith the following:

 

“A.   Pricing. Pursuant to Section 2.11 of the Standard Cardiolite® Terms, the Parties hereby agree that the current Exhibit I of the Standard Cardiolite® Terms is hereby amended as set forth in Exhibit 1 hereto.”

 

3.     Section II. B. Section II. B, “Good Faith Negotiations”, is amended by deleting such section in its entirety and replacing therewith the following:

 

“B.   Good Faith Negotiation. Once during each **** after January 1, 2009, but not sooner than three months after any previous price adjustment, UPPI and Medical Imaging may negotiate a potential change to the Fee Per Dose upon the mutual written agreement of Medical Imaging and UPPI (“the New Fee Per Dose”). The New Fee Per Dose will be effective the first day of the month following the execution of the written agreement. Medical Imaging and UPPI shall each negotiate any such changes to the Fee Per Dose in good faith based upon the then-existing selling conditions for Approved Sestamibi Products and with the aim of achieving competitive pricing. To expeditiously

 

 

implement the New Fee Per Dose UPPI agrees, on behalf of its members, to waive the notice requirements set forth in Section 2.11 of the Standard Cardiolite® Terms.”

 

2.     Section II. D. Section II. D, “Administrative Fee”, is amended by deleting such section in its entirety and replacing therewith the following:

 

“D.   Administrative Fee. Commencing in June 2009 and continuing through the month following the expiration of the Agreement, Medical Imaging shall pay to UPPI an Administrative Fee in the amount of ****% of the aggregate dollars billed in the immediately preceding month for Cardiolite® and Technelite® Generators by Medical Imaging to Members pursuant to this Agreement. Payment of the Administrative Fee is paid monthly, not later than 45 days after the close of any given month, during the Term of the Agreement.”

 

3.     Section III. B. Section III. B, “Purchase Price”, is amended by deleting such section in its entirety and replacing therewith the following:

 

“B.   Purchase Price. The Parties agree that each Member shall pay to Medical Imaging the Technelite® Generator Purchase Price as set forth in Exhibit 1 for Technelite® Generators and agree to the terms set forth on Exhibit 1. Such payment is due and payable as set forth in Medical Imaging’s invoices. The Members will be responsible for any and all federal, state, county or municipal sales or use tax, healthcare tax, excise, customs charges, duties or similar charges, or any other tax assessment (other than that assessed against Medical Imaging’s income), license, fee or other charge lawfully assessed or charged on the sale, transportation, or other disposition of Technelite® Generators.”

 

4.     Section IV. Section IV. “Rebates” is amended by deleting such section in its entirety and replacing therewith ****.

 

5.     Section V. Section V. (A)(1) “Term” is amended by deleting such section in its entirety and replacing therewith the following:

 

“1.              The term of this Agreement (“Term”) shall commence on the Effective Date and shall expire upon the earlier of (i) December 31, 2010, (ii) termination of the Agreement pursuant to Section V(A)(2) below.”

 

6.     Exhibit 1. Exhibit 1 is amended by deleting such exhibit in its entirety and replacing therewith Exhibit 1 attached hereto.

 

7.     General. Except as specifically modified hereby, the terms and provisions of the Agreement remain in full force and effect and otherwise unmodified. This Amendment is governed by and construed in accordance with the laws of the State of New York, without giving effect to the conflict of laws provisions thereof. The Agreement, as amended hereby, constitutes the entire agreement between the parties with respect to the subject matter hereof, and supersedes any and all prior or contemporaneous agreements between the parties relating to the subject matter hereof (whether written or oral). This Amendment may be executed in one or more counterparts, and by the different parties in

 

2

 

separate counterparts, each of which when executed is deemed to be an original but all of which when taken together shall constitute one and the same agreement.

 

3

 

IN WITNESS WHEREOF, the Parties, have caused this Amendment to be executed by their duly authorized officers as of the date first set forth above.

 

 

	
UNITED PHARMACY PARTNERS, INC.
  	
 
  	
LANTHEUS MEDICAL IMAGING, INC.
  
	
 
  	
 
  	
 
  
	
 
  	
 
  	
 
  
	
By:
  	
/s/ Perry Polsinelli
  	
 
  	
By:
  	
/s/ Donald R. Kiepert
  
	
 
  	
 
  	
 
  	
 
  	
 
  
	
Name:
  	
Perry Polsinelli
  	
 
  	
Name:
  	
DONALD R. KIEPERT
  
	
 
  	
 
  	
 
  	
 
  	
 
  
	
Title:
  	
President /CEO
  	
 
  	
Title:
  	
PRESIDENT & CEO
  
	
 
  	
 
  	
 
  	
 
  	
 
  
	
Date:
  	
April 24, 2009
  	
 
  	
Date:
  	
4/27/09
  

 

4

 

Exhibit 1

 

NOTICE OF INCENTIVE PROGRAMS AND PRICING
 FOR CARDIOLITE® AND TECHNELITE® GENERATORS

 

Lantheus Medical Imaging, Inc. (“Medical Imaging”) is pleased to make the following Program for Cardiolite® and Technelite® Generators available to all Members (each, a “Member”) of United Pharmacy Partners, Inc. (“UPPI”). All capitalized terms used but not otherwise defined herein will have the meanings set forth on Schedule A. The terms of this notice are confidential and are subject to the confidentiality provisions of Section 5.11 of your Standard Cardiolite® Terms.

 

I       Cardiolite® Pricing

 

A.     For the month of May 2009, UPPI members will pay a Fee Per Dose of ****.

 

B.      Thereafter and for the balance of the term of the Agreement, UPPI members will pay in any given month a Fee Per Dose of $**** provided that, in aggregate, UPPI members have purchased **** doses as reported on the Vial and Unit Dose Report as doses sold in the applicable Cardiolite® Reference Month.

 

C.      Should UPPI members fail to purchase **** doses but instead purchase in the aggregate between **** (the “Cardiolite® Minimum”) and **** doses in the applicable Cardiolite® Reference Month, then the Fee Per Dose for Cardiolite® in the then-current month will be $****.

 

D.      If, in any applicable Cardiolite® Reference Month, the aggregate doses purchased, as determined by the Vial and Unit Dose Report as doses sold, is less than the Cardiolite® Minimum, Medical Imaging reserves the right to (i) increase the Fee Per Dose for the then-current month to an amount not to exceed $**** and (ii) change the Technelite® Generator prices detailed in Grid 1 (2009) or Grid 2 (2010) of Exhibit 1, Section III, as the case may be, to the prices detailed in Grid 3 for the then-current month. If, in the following Cardiolite® Reference Month, the aggregate doses purchased, as determined by the Vial and Unit Dose Report as doses sold, is less than the Cardiolite® Minimum, Medical Imaging reserves the right to increase the Technelite® Generator prices for the then-current month to the prices detailed in Grid 4 of Exhibit 1, Section III.

 

E.      Starting in May 2009, UPPI shall have the right to purchase doses in a month to meet the Cardiolite® Minimum for the immediately preceding month provided that UPPI provides detailed notice (the “Notice”) of such purchases to Medical Imaging in that same month. The Notice must contain the UPPI member’s name and the number of vials purchased by such member in such month, that are to be applied to the Cardiolite® Minimum for the preceding month. Doses will be calculated by multiplying the Vial Utilization Base under which the vial was sold in such month by the number of vials purchased as detailed in the Notice. Doses purchased in such month to fulfill the Cardiolite® Minimum in the preceding month will not be included when calculating the achievement of the Cardiolite® Minimum when such month becomes a Cardiolite ® Reference Month.

 

5

 

II     Thallium Pricing

 

A.    For the month of May 2009, UPPI members will pay a price of $**** per millicurie for Thallium.

 

B.    Thereafter and for the balance of the term of the Agreement, UPPI members will pay a price of $**** per millicurie for Thallium provided that the number of millicuries of Thallium purchased by UPPI members in aggregate, in the Radiopharmaceutical Reference Month is greater than **** millicuries (the “Thallium Minimum”). If in any Radiopharmaceutical Reference Month the number of Thallium millicuries purchased falls below the Thallium Minimum, the price per millicurie for Thallium will be changed to $**** per millicurie in the then-current month.

 

III    Technelite® Generator

 

A.            Pricing for May 2009 is as set forth on Grid 1, Column A.

 

B.            Thereafter and for the balance of the term of this Agreement, pricing is as detailed in Grid 1 (2009) and Grid 2 (2010) below, as the case may be, provided that UPPI members have purchased in the aggregate a minimum of **** curies in the then applicable Radiopharmaceutical Reference Month (“Technelite® Generator Minimum”). Should the Technelite® Generator Minimum in the then-applicable Radiopharmaceutical Reference Month not be met or the Cardiolite® Minimum in the then-applicable Cardiolite® Reference Month not be met, then prices for Technelite® Generators detailed in Grid 1 (2009) and Grid 2 (2010) below will increase to the prices detailed in Grid 3 below for the then-current month. If the Technelite® Generator Minimum is not met in the following Radiopharmaceutical Reference Month or the Cardiolite® Minimum is not met in the following Cardiolite® Reference Month, Medical Imaging reserves the right to increase the Technelite® Generator prices to the prices detailed in Grid 4 below for the then-current month.

 

C.            Generator pricing, in each month, will be established based on ranges detailed in Grid 1 and Grid 2 below, as the case may be, as determined by the number of curies purchased plus the number of Technelite® Generator Unshipped Curies in the then-applicable Reference Month. In the event of an industry shortfall of molybdenum, curies purchased from orders placed during the shortfall will be included in the calculation to determine if the Technelite® Generator Minimum has been achieved; such orders, however, will not be included in any calculation that may determine a reduction in price.

 

D.            Medical Imaging may increase the Technelite® Generator purchase prices to reflect any material change in costs of molybdenum. A change in such costs is considered material if the increase in the cost of molybdenum over any **** (****) day period (a “Moly Cost Increase Period”) is more than **** percent (****%). In the event of such a material increase, Medical Imaging shall be entitled to increase the Technelite® Generator purchase prices to reflect the incremental increase in such costs over **** percent (****%) starting as of when such costs are actually incurred by Medical Imaging, provided that Medical Imaging provides UPPI **** (****) days written notice and reasonable documentation supporting such change in costs. Medical Imaging shall not implement the type of price increase detailed in this paragraph more than **** per calendar year.

 

6

 

III Technelite® Generator (cont.)

 

Technelite® Generators manufactured on Sunday are denoted with a “-u” below.

 

	
 
  	
 
  	
GRID 1
  	
 
  
	
 
  	
 
  	
A
  	
 
  	
B
  	
 
  	
C
  	
 
  
	
Generators
  	
 
  	
2009
 (excluding increases due to Mo-99 cost increases)
  	
 
  
	
mCi
  	
 
  	
****-**** Ci
  	
 
  	
**** -**** Ci
  	
 
  	
=>**** Ci
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  

 

	
 
  	
 
  	
GRID 2
  	
 
  
	
 
  	
 
  	
A
  	
 
  	
B
  	
 
  	
C
  	
 
  
	
Generators
  	
 
  	
2010
 (excluding increases due to Mo-99 cost increases)
  	
 
  
	
mCi 
  	
 
  	
****-**** Ci
  	
 
  	
**** -**** Ci
  	
 
  	
=>**** Ci
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  	
$
  	
****
  	
 
  

 

7

 

III Technelite® Generator (cont.)

 

Technelite® Generators manufactured on Sunday are denoted with a “-u” below.

 

	
Grid 3
  	
 
  	
Grid 4
  	
 
  
	
2009 (excluding increases due to
 Mo-99 cost increases)
  	
 
  	
2009(excluding increases due
 to Mo-99 cost increases)
  	
 
  
	
Generators
 mCi
  	
 
  	
 
  	
 
  	
Generators
 mCi
  	
 
  	
 
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
****
  	
 
  	
$
  	
****
  	
 
  
	
****
  	
 
  	
$
  	
****
  	
 
  	
****
  	
 
  	
$
  	
****
  	
 
  

 

Medical Imaging may update the prices for Technelite® Generators for Grid 3 and Grid 4 for ****, on or after ****, ****, upon **** days written notice to UPPI.

 

 

IV                                    Other Terms

 

A.                                   All rebate programs pursuant to the Agreement, as amended, and in effect prior to the Effective Date of this Amendment shall be calculated and paid if applicable, on a pro rata basis for a period ending ****, ****. After ****, all related rebate programs are no longer applicable.

 

B.                                     Each Member shall, during the Term, pay an amount to Medical Imaging equal to the then-effective Fee Per Dose for each dose of Sestamibi Product, the then-effective Technelite® Generator Purchase Price for purchases of Technelite® Generators and the then-effective per mCi price for purchases of Thallium delivered and invoiced to it by Medical Imaging.

 

C.                                     The terms of the existing Exhibit I of the Standard Cardiolite® Terms are being modified as set forth herein by each of the above terms. All references to Exhibit I to the Standard Cardiolite® Terms will be understood to reference and incorporate the terms contained herein.

 

D.                                    For the reporting period starting ****, Members will only be required to provide Medical Imaging with the Required Monthly Vial and Unit Dose Report (as described in Section 2.07(b)(i) of the Standard Cardiolite® Terms and Conditions).

 

E.                                      Any and all terms and conditions, if any, contained within the Standard Cardiolite® Terms that are inconsistent with this notice are hereby deleted, void and of no further force or effect.

 

F.                                      Each Member hereby represents and warrants that it will properly store, use and dispose of all materials provided pursuant to the Agreements in accordance with any instructions set forth on the applicable product labels, the rules and regulations promulgated by the U.S. Nuclear Regulatory Commission and all other applicable local, state and federal government regulations,

 

G.                                     Notwithstanding anything in Agreements to the contrary, the Agreement may be freely assigned by Medical Imaging.

 

H.                                 Notwithstanding anything in the Individual Pharmacy Agreements to the contrary, upon any amendment, modification or supplement to the Standard Cardiolite® Terms, Medical Imaging shall be required at any time to provide written notice thereof solely to UPPI at the following address:

 

United Pharmacy Partners, Inc.

5400 Laurel Springs Parkway, Suite 405

Suwanee, GA 30024

Attn: Perry Polsinelli

 

All notices to be provided to Medical Imaging  hereunder shall be delivered to:

 

Lantheus Medical Imaging, Inc.

331 Treble Cove Road,

North Billerica, Massachusetts

Attn: David Mann

 

2Exhibit
10.3

 

HQ Global
Workplaces Service Agreement

 

	
  Service
  Agreement Type:

  	
  

  	
  

  	
  

  	
  Agreement
  Date:

  	
  May 4,
  2005

  

 

	
  

  	
   

  	
  Business
  Center Bank Details

  
	
   

  	
   

  	
   

  
	
  Street/Floor

  	
   

  	
  4819 Emperor
  Blvd., Imperial Business Park - 4th Floor

  	
   

  	
  Name:

  	
   

  	
   

  
	
  City:

  	
   

  	
  Durham

  	
   

  	
  Sort code:

  	
   

  	
   

  
	
  State & Zip Code:

  	
   

  	
  NC, 27703

  	
   

  	
  Account number:

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  

 

	
  Client details (not an HQ center address)

  	
   

  	
  Corporate Account

  	
   

  	
  o Yes  PCA  o Yes

  
	
  Company
  Name:

  	
   

  	
  Tranzyme
  Pharmceuticals

  	
   

  	
  Federal ID No.:

  	
   

  	
   

  
	
  Address:

  	
   

  	
  3001
  12th Avenue North

  	
   

  	
  Contact
  Name/Title:

  	
   

  	
  Vipin
  K. Garg, Ph.D.

  
	
  State:

  	
   

  	
  Quebec

  	
   

  	
  City:

  	
   

  	
  Sherbrooke

  
	
  Telephone:

  	
   

  	
  819.820.6838

  	
   

  	
  Zip
  Code:

  	
   

  	
  J1H
  5N4

  
	
  Emergency
  Contact:

  	
   

  	
  919.434.6643

  	
   

  	
  Fax:

  	
   

  	
  819.820.6841

  
	
  Email
  Address:

  	
   

  	
  vgarg@tranzyme.com

  	
   

  	
  Emergency
  Phone:

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Invoicing details (if
  different)

  	
   

  	
  Contact
  Name/Title:

  	
   

  	
  Accounts
  Payable

  
	
  Company
  Name:

  	
   

  	
   

  	
   

  	
  City:

  	
   

  	
   

  
	
  Address:

  	
   

  	
   

  	
   

  	
  Zip
  Code:

  	
   

  	
   

  
	
  State:

  	
   

  	
   

  	
   

  	
  Fax:

  	
   

  	
   

  
	
  Telephone:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
											

 

The
standard fee (excluding tax)

 

	
  Office Number

  	
   

  	
  Market Office Price

  per Month $

  	
   

  	
  Monthly

  Office Price $

  	
   

  	
  Number of

  workstations

  	
   

  	
  Total per Month $

  	
   

  	
  Comments

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  447

  	
   

  	
  $

  	
  8,240.00

  	
   

  	
  $

  	
  6,180.00

  	
   

  	
  1

  	
   

  	
  $

  	
  6,180.00

  	
   

  	
  Please
  see addendum A,B,C

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  $

  	
  0.00

  	
   

  	
  455,456,457 Rent free for May

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  $

  	
  0.00

  	
   

  	
  $2700
  rent for month of June

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  $

  	
  0.00

  	
   

  	
  Free
  rent thereafter until occ.

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  $

  	
  0.00

  	
   

  	
  of
  Suite 447.

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  $

  	
  0.00

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  $

  	
  0.00

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
  Total per Month $

  	
   

  	
  $

  	
  6,180.00

  	
   

  	
   

  	
   

  
															

 

	
  Initial Payment:

  	
   

  	
  Monthly
  Office Payment

  	
   

  	
   

  	
   

  	
  $

  	
  6,180.00

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Service
  Retainer

  	
   

  	
  2

  	
   

  	
  $

  	
  10,180.00

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Monthly
  Taxes

  	
  Rate

  	
  0.00%

  	
   

  	
   

  	
  $

  	
  0.00

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Total Initial Payment

  	
   

  	
  $

  	
  16,360.00

  	
   

  	
   

  	
   

  
	
  Monthly Payment:

  	
   

  	
  Total Monthly Pymt (excl. of services)

  	
   

  	
  $

  	
  6,180.00

  	
   

  	
   

  	
   

  
												

 

	
  Length of Agreement

  	
   

  	
  Start
  date (MM/DD/YY):

  	
  May 1, 2005

  	
  End date (MM/DD/YY):

  	
   

  	
  February 28, 2006

  	
   

  

 

Comments

 

After first three months, client to have 30-day notice period to break
agreement without penalty. Proper written notice required to exercise the break
and must end the last day of the month.

 

Check here if you
do not consent to HQ processing data in accordance with Clause 28 of this
Agreement. o

 

We are HQ Global
Workplaces, Inc at 15305 North Dallas Parkway, 14th Floor, Addison, TX
75001.  This Agreement incorporates our
terms of business set out on attached Terms of Business which you confirm you
have read and understood.  We both agree
to comply with those terms and our obligations as set out in them.  Note that the Agreement does not come to an
end automatically.  See “Bringing your
Agreement to an end”.

 

	
  Name
  (printed)

  	
  /s/
  Richard I. Eisenstadt

  	
   

  	
  Name
  (printed)

  	
  Jennifer
  Dittmer

  
	
  Title
  (printed)

  	
  Richard
  I. Eisenstadt

  	
   

  	
  Title
  (printed)

  	
  Sales
  Manager

  
	
  Date
  (MM/DD/YY)

  	
  5/6/2005

  	
   

  	
  Date
  (MM/DD/YY)

  	
  4/28/2005

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  SIGNED on your behalf (Client)

  	
   

  	
  SIGNED on our behalf (HQ Global Workplaces, Inc)

  

 

 

 

Terms of Business

USING HQ
BUSINESS CENTERS

 

1. We Are
HQ Global Workplaces Inc. known hereafter as “HQ”.

 

These are our terms of
business. They apply to the service Agreement which you the client have signed
(which we refer to simply as your Agreement).

 

Your Agreement supersedes
any previous Agreement you may have with us for the same services and contains
all the terms we have agreed.

 

STANDARD
SERVICES INCLUDED IN YOUR STANDARD FEE

 

2.
Furnished Office Accommodation

 

We are to provide the number
of serviced and fully furnished accommodations for which you have agreed to pay
in the business center stated in your Agreement (also referred to in this
Agreement as the “Furnished Office Accommodation” or the “Accommodation(s)”).
Your Agreement lists the accommodations we have initially allocated for your
use.

 

Occasionally, we may need to
allocate different accommodations, but these will be of equivalent size and we
will attempt to obtain your approval with respect to such different
accommodations in advance.

 

3. Office
Services

 

We are to provide the
services described on the front of this Agreement, the HQ workstation or cube
offer and the Connectivity Order during normal operating hours Monday to
Friday. (Connectivity is available 24/7) 

 

We are happy to discuss
special arrangements for use of these services outside our normal operating
hours. All services are subject to the availability of our center team at the
time of any service request. We will endeavor to deal with a service request at
the earliest opportunity, but will not be held responsible for any delay.

 

If in our opinion, we decide
that a request for any particular Business Service is excessive, we reserve the
right to charge an additional fee at our usual published rates based on the
time taken to complete the service.

 

4. HQ
Internet Access

 

You must comply with any
copyright notices, license terms or other notices appearing on screen or as
part of any material on the Internet or our network. You must not copy, use or
exploit such software or other material in any way, unless we have explicitly
given you permission to do so. You must strictly comply with the terms of any
permission that we give.

 

We do not make any
representations as to the security of our network (or the Internet) or of any
information that you place on it. You should adopt whatever security measures
(such as encryption) you believe are appropriate to your circumstances.

 

We cannot guarantee that a
particular degree of availability will be attained in connection with your use
of the services.

 

You hereby warrant to us
that our provision of these services to you will not infringe the rights of any
third party.

 

You agree to comply with the
HQ Technology Policy as set out on the HQ acceptable use policy located in your
welcome pack upon move in.

 

We warrant that the services
shall be provided and performed in a professional and workmanlike manner and
shall conform to the description of the services set out in the offers for “HQ
Connectivity Services”. If we fail to provide the services as warranted, your
sole and exclusive remedy shall be the remedy of such failure by us within a
reasonable time after written notice.

 

The above warranty is in
lieu of all other terms, conditions and warranties, whether express or implied
by usage, custom, statute or otherwise, appertaining to the services and manner
in which we perform our obligations and exercise our rights including, but
without prejudice to the generality of the foregoing, such as relate to the
description, performance, quality, suitability or fitness for any particular
purposes, of the services. We do not warrant that the services will be
uninterrupted or error free.

 

USING THE
ACCOMMODATION

 

5. On
Moving In

 

You will be asked to sign an
inventory of all accommodation(s), furniture and equipment you are permitted to
use, together with a note of its condition, and details of the keys or entry
cards issued to you. You may at any time have as many employees working in your
accommodation(s) as there are allowable workstations. This number is noted
on the front of this Agreement. If at any time you exceed the number of people
than there are workstations those employees will pay the hourly or daily rate
for additional accommodations. This fee will be in addition to the monthly
supplemental fee and Hotdesk fee.

 

6. The
Nature Of Your Business

 

You must only use the
accommodation for office purposes, and only for the business stated in your
Agreement or subsequently agreed with us. Office use of a “retail” nature,
involving frequent visits by members of the public, is not permitted. You must
not carry on a business which competes with our business of providing serviced
office accommodations. You must not use the name HQ in any way in connection
with your business.

 

7. Your
Name And Address

 

You may only carry on that
business in your name or some other name that we previously agree. At your
request and cost we will include that name in the house directory at the
business center, where this is available. You must not put up any signs on the
doors to your accommodation or anywhere else which is visible from outside the
Accommodation you are using. You may use the business center address as your
business address. If you use the center address as your registered business
address, you must have a third-party registered as your agent for service of
process.

 

8. Taking
Care Of Our Property

 

You must take good care of
all parts of the business center, its equipment, fittings and furnishings which
you use. You must not alter any part of it. You are liable for any damage
caused by you or those in the business center with your permission or at your
invitation.

 

9. Office
Furniture And Equipment

 

You must not install any
furniture or office equipment, cabling, IT or telecom connections without
our consent, which we may refuse at our absolute discretion.

 

10. Keys
And Security

 

Any keys or entry cards
which we let you use remain our property at all times. You must not make any
copies of them or allow anyone else to use them without our consent. Any loss
must be reported to us immediately and you must pay the cost of replacement
keys or cards and/ or changing locks, if required. If you are permitted to use
the business center outside normal working hours it is your responsibility to
lock the doors to your accommodation and to the business center when you leave.

 

11. Comply
With The Law

 

You must comply with all
relevant laws and regulations in the conduct of your business. You must do
nothing illegal. You must not do anything that may interfere with the use of
the business center by us or by others, cause any nuisance or annoyance,
increase the insurance premiums we have to pay or cause loss or damage to us or
to the owner of any interest in the building which contains the business
center. You acknowledge that (a) the terms of the foregoing sentence are a
material inducement to us for the execution of your Agreement and (b) any
violation by you of the foregoing sentence shall constitute a material default
by you hereunder, entitling us to terminate your Agreement.

 

12. Comply
With House Rules

 

You must comply with any
house rules which we impose generally on users of the business center
whether for reasons of health and safety, fire precautions or otherwise.

 

13.
Insurance

 

It is your responsibility to
arrange insurance for your own property which you bring into the business
center and for your own liability to your employees and to third parties.

 

PROVIDING
THE SERVICES

 

14. Access
To Your Accommodation

 

We can enter your
accommodation at any time. However, unless there is an emergency we will as a
matter of courtesy try to inform you in advance when we need access to carry
out testing, repair or works other than routine inspection, cleaning and
maintenance. We will also respect security procedures to protect the confidentiality
of your business. 

 

15. At The
Start Of Your Agreement

 

If for any reason we cannot
provide the Accommodation(s) stated in your Agreement by the date when
your Agreement is due to start we have no liability to you for any loss or
damages but you may cancel the Agreement without penalty. We will not charge
you the standard fee for accommodations you cannot use until they become
available.

 

16.
Suspension Of Services

 

We may by notice suspend the
provision of services (including access to the business center) for reasons of
political unrest, strikes, or other events beyond our reasonable control, in
which event payment of the standard fee will also be suspended for the same
period.

 

17. Our
Liability

 

We are not liable for any
loss as a result of our failure to provide a service as a result of mechanical
breakdown, strike, delay, failure of team, termination of our interest in the
building containing the business center or otherwise unless we do so
deliberately or are grossly negligent. We are also not liable for any failure
until you have informed us about it in writing and given us a reasonable time
to put right.

 

You agree (a) that we
will not have any liability for any loss, damage or claim which arises as a
result of, or in connection with, your Agreement and/or your use of the
services except to the extent that such loss, damage, expense or claim is directly
attributable to our deliberate act or our gross negligence (our liability); and
(b) that our liability will be subject to the limits set out in the next
paragraph.

 

We will not in any
circumstances have any liability for loss of business, loss of profits, loss of
anticipated savings, loss of or damage to data, third party claims or any
consequential loss. We strongly advise you to insure against all such potential
loss, damage expense or liability.

 

We will be liable:

 

·                  up to a maximum of
$1,000,000 (for any one event or series of connected events) for damage to your
personal property;

 

·                  up to a maximum equal to
125% of the total fees paid under your Agreement up to the date on which the
claim in question arises or $50,000 (whichever is the higher), in respect of
all other losses, damages expenses or claims.

 

YOUR
AGREEMENT

 

18. The
Nature Of Your Agreement

 

Your Agreement is the
commercial equivalent of an Agreement for accommodation in a hotel. The whole
of the business center remains our property and in our possession and control.
You acknowledge that your Agreement creates no tenancy interest, leasehold
estate or other real property interest in your favor with respect to the accommodation.
We are giving you just the right to share with us the use of the business
center so that we can provide the services to you. The Agreement is personal to
you and cannot be transferred to anyone else. We may transfer the benefit of
your Agreement and our obligations under it at any time.

 

19.
Duration

 

Your Agreement lasts for the
period stated in it and will then automatically be extended for successive
periods equal to the current term but no less than 3 months until brought to an
end by you or by us. All periods shall run to the last day of the month in
which they would otherwise expire. The fees on any renewal will be the market
price listed on the front of the service Agreement. In all other respects your
Agreement will renew on the same terms and conditions.

 

20.
Bringing Your Agreement To An End

 

Either of us can terminate
your Agreement at the end date stated in it, or at the end of any extension or
renewal period, by giving at least three months written notice to the other.
However, if your Agreement, extension or renewal is for three months or less
and one of us wishes to terminate it, the notice period is two months or if
shorter one week less than the period stated in your Agreement, extension or
renewal.

 

21. Ending
Your Agreement Immediately

 

We may put an end to your
Agreement immediately by giving you notice if: you become insolvent, go into
liquidation or become unable to pay your debts as they fall due, you are in
breach of one of your obligations which cannot be put right or which we have
given you notice to put right and which you have failed to put right within
fourteen days of that notice, or your conduct, or that of someone at the
business center with your permission or at your invitation, is incompatible with
ordinary office use.

 

If we put an end to the
Agreement for any of these reasons it does not put an end to any then
outstanding obligations you may have and you must:

 

·                  pay for additional services
you have used

 

·                  pay the standard fee for the
remainder of the period for which your Agreement would have lasted had we not
ended it, or (if longer) for a further period of three months, and

 

·                  indemnify us against all
costs and losses we incur as a result of the termination.

 

22. If The
Business Center Is Not Available

 

In the unlikely event that
we are no longer able to provide the services and accommodation at the business
center stated in your Agreement then your Agreement will end and you will only
have to pay standard fees up to the date it ends and for the additional
services you have used. We will try to find a suitable alternative
accommodation for you at another Regus/HQ business center.

 

23. When
Your Agreement Ends

 

Upon your departure or if
you, at your option, choose to relocate to a different accommodation within the
business center a flat fee ($250.00 per office) will be assessed to cover the
routine cost of repainting and redecorating the accommodation to return it to
its original condition in addition to general maintenance to the common areas
of the business center in which you have had access. We reserve the right to
charge additional reasonable fees for any repairs needed above and beyond
normal wear and tear. If you leave any of your own property in the business
center we may dispose of it in any way we choose without owing you any
responsibility for it or any proceeds of sale. 

 

In order to transition your
mail and telephone calls from the business center, you will be automatically
entered into a HQ Virtual Office (“VO”) Agreement with us on our standard terms
at the time for 3 months. Current contract terms and pricing can be obtained
online or through your HQ General Manager. 

 

If you continue to use the
accommodation when your Agreement has ended: 

 

·                  you are responsible for any
loss, claim or liability we incur as a result of your failure to vacate on
time.

 

·                  we may, at our discretion,
permit you an extension subject to a surcharge on the standard fee.

 

24.
Employees

 

While your Agreement is in
force and for a period of six months after it ends, you must not solicit or
offer employment to any of our current employees or anyone who has left our
employment in the last 3 months. If you do, we estimate our loss at the
equivalent of one year’s salary for each of the employees concerned and you
must pay us damages equal to that amount.

 

25. Notices

 

All formal notices must be
in writing. Client is responsible to keep current address of record on file
with the center.

 

26.
Confidentiality

 

The terms of your Agreement
are confidential. Neither of us may disclose them without the other’s consent
unless required to do so by law or an official authority. This obligation
continues after your Agreement ends.

 

27.
Indemnities

 

You must indemnify us in
respect of all liability, claims, damages, loss and expenses which may arise
(except to the extent caused by our gross negligence or willful misconduct).

 

·                  If someone dies or is
injured while in the accommodation you are using.

 

·                  From a third party in
respect of your use of the business center and the services.

 

·                  If you do not comply with
the terms of your Agreement.

 

You must also pay any cost,
including reasonable legal fees, which we incur in enforcing your Agreement.

 

28. Data
Protection

 

You agree that we may
process, disclose or transfer (including outside the EEA — European Economic
Area - to other countries which are part of our international network from time
to time) any personal data which we hold on or in relation to you provided that
in doing so we take such steps as we consider reasonable to ensure that it is
used only to fulfill our obligations under your Agreement; for work assessment
and fraud prevention; or to make available information about new or beneficial
products and services offered by us and other organizations which we consider
may be of interest to you.

 

Please be aware that
countries outside the EEA — European Economic Area - may not have laws in force
to protect your personal data.

 

29.
Applicable Law

 

Your Agreement is
interpreted and enforced in accordance with the laws of the state in which the
business center in question is located. We both accept the exclusive
jurisdiction of the courts of such jurisdiction where the center is located.

 

FEES

 

In the following clauses any
references to “fees” alone means all of the standard service fees,
pay-as-you-use fees, the Business Services price, and the Connectivity Service
price.

 

30.
Standard Services

 

The standard fee, the
Business Services price (if applicable), the Connectivity Service price (if
applicable) and the Telecom Services price (if applicable) plus appropriate
taxes and all other fees and charges referred to in our service Agreement, in
accordance with our published rates which may change from time to time, are
invoiced in respect of the services to be provided during the following month
in advance in full on the 1st day (or such other day as we designate) of each
month. You agree to pay promptly all (i) sales, use, excise and any other
taxes, surcharges or license fees which you are required to pay to any governmental
authority (and, at our request, will provide to use evidence of such payment),
and (ii) any taxes paid by us attributable to your accommodation,
including, without limitation, any gross receipts, rent and occupancy taxes,
surcharge fees or tangible personal property taxes. The Business and
Connectivity Service Packages or Business and Connectivity Supplemental Service
are mandatory for the Cube and Hotdesk offering.

 

31.
Additional Services

 

Fees for additional
services, plus applicable taxes, in accordance with our published rates which
may change from time to time, are invoiced in arrears and payable on the 1st
day (or such other day as we designate) of the month following the calendar
month in which the additional services were provided.

 

32. Service
Retainer

 

You will be required to pay
a service retainer equivalent to 2 months standard office fee on entering into
your Agreement. This will be held by us as security for performance of all your
obligations under your Agreement. The service retainer, or any balance after
deducting outstanding fees, three months Business Continuation fee, and other costs
due to us, will be returned to you within 30 days of the date you have settled
your account with us in full. We may require you to pay an increased retainer
if outstanding fees exceed the service retainer held or if you frequently fail
to pay us when due.

 

33. Late
Payment

 

If you do not pay fees when
due, a service fee of $25.00 plus 5% interest will be charged on all overdue
balances under $1,000.00 or a fee of $50.00 plus 5% interest on all overdue
balances will be charged on all overdue balances of $1,000.00 or greater. If
you dispute a part of any invoice you must pay the amount not in dispute by the
due date or be subject to late fees. The amount of interest and fees we charge
will be the lesser of the amounts stated, or the State’s legally enforceable
maximum, whichever is the lesser. In the case of U.S. Government Contracts, the
amount of interest and fees we charge will be lesser of the amounts stated or
those set by the Secretary of the Treasury and implemented by the Prompt
Payment Act.

 

34.
Insufficient Check Fees

 

You will pay a fee of $25.00
or the maximum amount permitted by law for the return of any payment for
insufficient funds.

 

35. Subordination

 

Your Agreement is
subordinate to our lease with our landlord and to any other Agreements to which
our lease with our landlord is subordinate.

 

36. Annual
Increase

 

We will increase your
current standard service fee on each and any annual anniversary of the start
date of your Agreement by 4% or the CPI, whichever is greater, or such other
broadly equivalent index which we substitute, over the previous year. This will
only apply to Agreements that have an original start and end date constituting
more than a 12 month term. Renewals do not fall under this category and will be
renewed as per clause 19 above.

 

	
  Client Initials

  	
  RIE

  	
   

  

 

 

 

 

This
Exhibit “A” is attached to and made a part of HQ, a member of the Regus
Group Network (“HQ”) Service Agreement (the “Service Agreement”) between
Tranzyme, Inc.  (“Client”) and HQ,
entered as of this 6th day of May, 2005 for Suite 447, located at 4819
Emperor Blvd., Durham, NC 27703, USA.

 

WHEREAS
the parties agree to modify certain terms of the Service Agreement as described
herein:

This
Addendum is made a part of the existing Service Agreement dated May 06,
2005.

 

Client
to occupy offices 455, 456, 457, 466, and 471 until construction is completed
per attached addendum B in suite 447. HQ shall be responsible for contracting
to have the space demised and any associated improvements. Tranzyme agrees
to front $18,000.00 on July 01, 2005 for such work. These funds will in
effect pre-pay rent for July, August, and September, 2005. HQ agrees to waive
the monthly office fee for Suite 447 during the first (3) months of
occupancy of Suite 447. HQ will invoice Tranzyme for any balance due,
including a staggered deposit schedule as detailed in Addendum C. HQ will be
financially responsible for any construction cost above $18,000.00, with the
exception of any special requests or additional requirements from Tranzyme.

 

The term of this Addendum shall be for 10 months terminating on February 28,
2006. Along with original service agreement, it will automatically renew
for another six months if a termination or extension is not provided in writing
by December 01, 2005. It is further provided that all of the other terms
of the existing Service Agreement (and any subsequent Addenda) shall apply to
the above noted suite and workstations and, except as set forth above, all of
the terms and conditions of the existing Service Agreement (and any subsequent
Addenda) shall remain in full force and effect.

 

AGREED to this 6th day of May, 2005

 

	
  HQ,
  a member of the Regus Group Network

  	
   

  	
  Tranzyme, Inc.

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  By:
  

  	
  /s/
  Aaron M. Bittikofer

  	
   

  	
  By:
  

  	
  /s/
  Richard I. Eisenstadt

  
	
   

  	
  Name:

  	
  Aaron
  M. Bittikofer

  	
   

  	
   

  	
  Name:
  

  	
  Richard
  I. Eisenstadt

  
	
   

  	
  Title:

  	
  General Manager

  	
   

  	
   

  	
  Title:

  	
  CFO

  
								

 

RTP Center

4819 Emperor Blvd.

4th Floor

Durham NC 27703

T 919-313-4500    F 919-313-4508

 

 

 

 

 

 

This
Exhibit “C” is attached to and made a part of HQ, a member of the Regus
Group Network (“HQ”) Service Agreement (the “Service Agreement”) between
Tranzyme, Inc.  (“Client”) and HQ,
entered as of this 6th day of May, 2005 for Suite 447, located at 4819
Emperor Blvd., Durham, NC 27703, USA.

 

WHEREAS
the parties agree to modify certain terms of the Service Agreement as described
herein:

 

This
Addendum is made a part of the existing Service Agreement dated May 06,
2005. Client agrees to pay a refundable service retainer to HQ due
on the following dates:

 

	
  MAY 09, 2005: 

  	
  $

  	
  1000

  	
   

  
	
  JUNE 01, 2005: 

  	
  $

  	
  3000

  	
   

  
	
  SEPT 01, 2005: 

  	
  $

  	
  6180

  	
   

  

 

The term of this Addendum shall be for 10 months terminating on February 28,
2006. Along with original service agreement, it will automatically renew
for another six months if a termination or extension is not provided in writing
by December 01, 2005. It is further provided that all of the other terms
of the existing Service Agreement (and any subsequent Addenda) shall apply to
the above noted suite and workstations and, except as set forth above, all of
the terms and conditions of the existing Service Agreement (and any subsequent
Addenda) shall remain in full force and effect.

 

AGREED to this 6th day of May, 2005

 

 

	
  HQ, a member of the Regus Group Network

  	
  Tranzyme, Inc.

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
  By:

  	
  /s/
  Aaron M. Bittikofer

  	
   

  	
  By:

  	
  /s/
  Richard I. Eisenstadt

  
	
   

  	
  Name:

  	
  Aaron
  M. Bittikofer

  	
   

  	
  Name:

  	
  Richard
  I. Eisenstadt

  
	
   

  	
  Title:

  	
  General
  Manager

  	
   

  	
  Title:

  	
  CFO

  
							

 

RTP Center

4819 Emperor Blvd.

4th Floor

Durham NC 27703

T 919-313-4500 F 919-313-4508

 

 

 

 

 

Office Agreement Addendum

 

This Office Agreement Addendum (“Addendum”) is
made and entered into on the 6 day of May, 2005, by and between HQ GLOBAL WORKPLACES, INC. (“HQ”) and Tranzyme Inc. (“Client”).

 

Recitals

 

A.            Client
and HQ are parties to that certain Office Agreement (“Office Agreement”) dated May 6,
2005 in which HQ provides certain services and facilities to you.

 

B.            The
parties desire to amend the terms of the Office Agreement under the following
terms and conditions.

 

NOW, THEREFORE, for and in consideration
of the mutual covenants and promises contained herein and other good and
valuable considerations, the parties agree as follows:

 

1.               Duration will be amended by deleting the entire
section and replacing it with the following verbiage, “Your agreement lasts for
the period stated in it and will then automatically terminate.  In the event you stay in the space after the
termination, you will be bound by the terms and conditions of the original
agreement and a holdover fee of 110% of the standard fee will be charged and
can only be for a duration of 3 months after terminating date on
agreement.  After that period of time you
must either vacate the premises or enter into a new service agreement.”

2.               Bringing your agreement to an end will be amended by
changing the length of termination from ninety (90) days to sixty (60)
days.  For all agreements on a month — to
— month basis shall only need fourteen (14) day’s notice.

3.               When your agreement ends will be amended by charging a
fee of $175 for normal wear and tear if HQ elects to charge client.  The Virtual Office agreement on exiting after
termination will be an option not a mandatory service.

4.               Clause 30 will only apply to the Business Services
Guide.  All fixed recurring costs,
excluding monthly office fee, do not apply.

 

In Witness
Whereof, the parties have executed
this Addendum as of the date first above written.

 

Client:

 

Tranzyme
Inc.

 

	
  By:

  	
  /s/ Richard I. Eisenstadt

  	
   

  
	
  Name:

  	
  Richard I. Eisenstadt

  	
   

  
	
  Title:

  	
  CFO

  	
   

  

 

 

HQ:

 

HQ
GLOBAL WORKPLACES, INC.

 

	
  By:

  	
  /s/ Aaron M. Bittikofer

  	
   

  
	
  Name:

  	
  Aaron M. Bittikofer

  	
   

  
	
  Title:

  	
  General Manager

  	
   

  

 

 

 

	
  

  	
  

  	
  Renewal
  Agreement

  

 

	
  Client Details

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Company Name:

  	
   

  	
  Tranzyme

  	
   

  	
  Center:

  	
   

  	
  Durham Imperial

  
	
  Contact Name:

  	
   

  	
  Richard Eisenstadt

  	
   

  	
  Reference No.:

  	
   

  	
  2596841

  

 

[ILLEGIBLE]

 

	
   

  	
   

  	
   

  	
   

  	
  [ILLEGIBLE]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
  12 Months

  	
   

  	
  Months

  	
   

  	
  Months

  	
   

  	
   

  
	
  Office Number

  	
   

  	
  Market Office Fee

  	
   

  	
  Option A

  	
   

  	
  Option B

  	
   

  	
  Option C

  	
   

  	
   

  
	
  441

  	
   

  	
  1,320.00

  	
   

  	
  844.80

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  446

  	
   

  	
  1,010.00

  	
   

  	
  598.00

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  447

  	
   

  	
  12,240.00

  	
   

  	
  7,833.60

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  448

  	
   

  	
  1,330.00

  	
   

  	
  851.20

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  449

  	
   

  	
  1,400.00

  	
   

  	
  896.00

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  478

  	
   

  	
  810.00

  	
   

  	
  518.40

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Total
  per Month

  	
   

  	
   

  	
   

  	
  11,542.00

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  USD

  

 

	
  Start Date of Renewal:

  	
   

  	
  December 1, 2009

  

 

Comments:

 

Client will
have a 60 day notice period from the agreement end date. Original terms,
conditions and addendums remain unchanged. (See Addendums A, B and C)

 

Please place an “X” in the shaded box next to your preferred option:

 

	
  Option A:
  I agree

  	
   

  	
  x

  
	
   

  	
   

  	
   

  
	
  Option B:
  I agree

  	
   

  	
  o

  
	
   

  	
   

  	
   

  
	
  Option C:
  I agree

  	
   

  	
  o

  
	
   

  	
   

  	
   

  
	
  I do not
  wish to renew

  	
   

  	
  o

  

 

	
  /s/ Richard I. Eisenstadt

  	
   

  	
  30 Sep 09

  
	
  SIGNED on your behalf (Client)
  Richard I. Eisenstadt

  	
   

  	
  Date

  

 

 

	

  	
 
  
	
 
  
	
Office Service Renewal
  
	
 
  

 

	
Agreement Date (mm/dd/yy):
  	
October 19, 2010
  	
Reference No.: 
  	
3099019
  

 

	
Business Center Address:
  	
Client Address (Not a Regus Center Address):
  
	
Raleigh/Durham Imperial Center
  	
Company Name:
  	
Tranzyme
  
	
4819 Emperor Blvd, Suite 400 Durham, NC 27703
  	
Contact Name:
  	
Richard Eisenstadt
  
	
Tara Wilson
  	
Address:
  	
 
  
	
tara.wilson@regus.com
  	
Address:
  	
 
  
	
919-313-4500
  	
Phone & Email:
  	
 
  

 

Office Payment Details (excluding tax and excluding services)

 

	
Office Number
  	
 
  	
No. of People
  	
 
  	
Market Office Fee
  	
 
  	
Monthly Office Fee
  	
 
  	
 
  
	
441
  	
 
  	
0
  	
 
  	
1,320
  	
 
  	
844.00
  	
 
  	
 
  
	
446
  	
 
  	
0
  	
 
  	
1,010
  	
 
  	
598.00
  	
 
  	
 
  
	
447
  	
 
  	
8
  	
 
  	
12,240
  	
 
  	
7,833.00
  	
 
  	
 
  
	
448
  	
 
  	
1
  	
 
  	
1,330
  	
 
  	
851.00
  	
 
  	
 
  
	
449
  	
 
  	
2
  	
 
  	
1,400
  	
 
  	
896.00
  	
 
  	
 
  
	
478
  	
 
  	
1
  	
 
  	
810
  	
 
  	
518.00
  	
 
  	
 
  
	
 
  	
 
  	
 
  	
 
  	
 
  	
 
  	
 
  	
 
  	
 
  
	
Total per Month
  	
 
  	
 
  	
 
  	
 
  	
 
  	
 
  	
11,540
  	
 
  	
USD
  
	
 
  	
 
  	
 
  	
 
  	
 
  	
 
  	
 
  	
 
  	
 
  
	
Initial Payment
  	
 
  	
First Month’s Fee
  	
 
  	
 
  	
 
  	
 
  	
 
  	
 
  
	
 
  	
 
  	
Service Retainer
  	
 
  	
2
  	
 
  	
 
  	
 
  	
 
  
	
 
  	
 
  	
Total Initial Payment
  	
 
  	
 
  	
 
  	
 
  
	
 
  	
 
  	
 
  	
 
  	
 
  	
 
  	
 
  	
 
  	
 
  
	
Monthly Payment
  	
 
  	
Total Monthly Payment Thereafter
  	
 
  	
11,540
  	
 
  	
 
  
	
 
  	
 
  	
 
  	
 
  	
 
  	
 
  	
 
  	
 
  	
 
  
	
Length of Agreement:
  	
 
  	
Start Date
  	
 
  	
December 1, 2010
  	
 
  	
End Date*
  	
 
  	
November 30, 2010
  
										

 

* All agreements end on the last calendar day of the month.

 

Comments:

 

See addendum.  Retainer already on file.

 

We are Regus Management Group LLC.,(“Regus”).  This Agreement incorporates our terms of business set out on attached Terms and Conditions which you confirm you have read and understood.  We both agree to comply with those terms and our obligations as set out in them.  Note that the Agreement does not come to an end automatically.  See “Bringing your Agreement to an end”.

 

 

	
Name (printed)
  	
Richard I. Eisenstadt
  	
 
  	
Name (printed)
  	
Tara Wilson
  
	
 
  	
 
  	
 
  	
 
  	
 
  
	
Title (printed)
  	
CFO
  	
 
  	
Title (printed)
  	
Center Manager
  
	
 
  	
 
  	
 
  	
 
  	
 
  
	
Date
  	
22 Nov 2010
  	
 
  	
Date
  	
11/22/10
  
	
 
  	
 
  	
 
  	
 
  	
 
  
	
SIGNED on your behalf (Client)
  	
 
  	
SIGNED on our behalf
  
	
 
  	
 
  	
 
  
	
/s/ Richard I. Eisenstadt
  	
 
  	
/s/ Tara Wilson
  

 

o            We would like to keep you informed of the latest product news, special offers and other marketing information from preferred partners. If you would like to receive this information then select this box.

 

 

TERMS AND CONDITIONS

 

1. This Agreement

 

1.1                                 Nature of this agreement: This agreement is the commercial equivalent of an agreement for accommodation(s) in a hotel. The whole of the Center remains in Regus’ possession and control. THE CLIENT ACCEPTS THAT THIS AGREEMENT CREATES NO TENANCY INTEREST, LEASEHOLD ESTATE OR OTHER REAL PROPERTY INTEREST IN THE CLIENT’S FAVOR WITH RESPECT TO THE ACCOMMODATION(S). Regus is giving the Client the right to share with Regus the use of the Center on these terms and conditions, as supplemented by the House Rules, so that Regus can provide the services to the Client. This agreement is personal to the Client and cannot be transferred to anyone else. This agreement is composed of the front page describing the accommodation(s), the present terms and conditions and the House Rules. 

 

1.2                                 Comply with House Rules: The Client must comply with any House Rules which Regus imposes generally on users of the Center. The House Rules vary from country to country and from Center to Center and these can be requested locally. 

 

1.3                                 Duration: This agreement lasts for the period stated in it and then will be extended automatically for successive periods equal to the current term but no less than 3 months (unless legal renewal term limits apply) until brought to an end by the Client or by Regus. All periods shall run to the last day of the month in which they would otherwise expire. The fees on any renewal will be at the then prevailing market rate. 

 

1.4                                 Bringing this agreement to an end: Either Regus or the Client can terminate this agreement at the end date stated in it, or at the end of any extension or renewal period, by giving at least three months written notice to the other. However, if this agreement, extension or renewal is for three months or less and either Regus or the Client wishes to terminate it, the notice period is two months or (if shorter) one week less than the period stated in this agreement. 

 

1.5                                 Ending this agreement immediately: To the maximum extent permitted by applicable law, Regus may put an end to this agreement immediately by giving the Client notice and without need to follow any additional procedure if (a) the Client becomes insolvent, bankrupt, goes into liquidation or becomes unable to pay its debts as they fall due, or (b) the Client is in breach of one of its obligations which cannot be put right or which Regus have given the Client notice to put right and which the Client has failed to put right within fourteen (14) days of that notice, or (c) its conduct, or that of someone at the Center with its permission or invitation, is incompatible with ordinary office use.

 

If Regus puts an end to this agreement for any of these reasons it does not put an end to any outstanding obligations, including additional services used and the monthly office fee for the remainder of the period for which this agreement would have lasted if Regus had not ended it. 

 

1.6                                 If the Center is no longer available: In the event that Regus is permanently unable to provide the services and accommodation(s) at the Center stated in this agreement then this agreement will end and the Client will only have to pay monthly office fees up to the date it ends and for the additional services the Client has used. Regus will try to find suitable alternative accommodation(s) for the Client at another Regus Center. 

 

1.7                                 When this agreement ends the Client is to vacate the accommodation(s) immediately, leaving the accommodation(s) in the same condition as it was when the Client took it. An exit fee will be charged upon the Client’s departure or if the Client, at its option, chooses to relocate to different rooms within the Center. This rate will differ by country and is listed in the House Rules. Regus reserves the right to charge additional reasonable fees for any repairs needed above and beyond normal wear and tear. If the Client leaves any property in the Center Regus may dispose of it at the Client’s cost in any way Regus chooses without owing the Client any responsibility for it or any proceeds of sale. The Client will be automatically entered into a Virtual Office agreement (“VO”) with Regus on Regus’ standard terms at the time for 3 months (where applicable by law). This VO endeavors to provide business continuity for the Client as it ensures that Regus can effectively manage its transition period. 

 

If the Client continues to use the accommodation(s) when this agreement has ended the Client is responsible for any loss, claim or liability Regus incurs as a result of the Client’s failure to vacate on time. Regus may, at its discretion, permit the Client an extension subject to a surcharge on the monthly office fee. 

 

1.8                                 Employees: While this agreement is in force and for a period of six months after it ends, neither Regus nor the Client may knowingly solicit or offer employment to any of the other’s staff employed in the Center. This obligation applies to any employee employed at the Center up to that employee’s termination of employment, and for three months thereafter. It is stipulated that the breaching party shall pay the non-breaching party the equivalent of one year’s salary for any employee concerned. Nothing in this clause shall prevent either party from employing an individual who responds in good faith and independently to an advertisement which is made to the public at large. 

 

1.9                                 Client Representation of Regus Employees: Throughout the duration of this agreement, Client agrees that neither Client, nor any of Client’s partners, members, officers or employees will represent, or otherwise provide legal counsel to, any of Regus’ current or former employees in any dispute with, or legal proceeding against, Regus, or any of Regus’ affiliates, members, officers or employees. 

 

1.10                           Notices: All formal notices must be in writing to the address first written above. 

 

1.11                           Confidentiality: The terms of this agreement are confidential. Neither Regus nor the Client must disclose them without the other’s consent unless required to do so by law or an official authority. This obligation continues after this agreement ends. 

 

1.12                           Applicable law: This agreement is interpreted and enforced in accordance with the law of the place where the relevant Center is located. Regus and the Client both accept the exclusive jurisdiction of the courts of such jurisdiction. If any provision of these terms and conditions is held void or unenforceable under the applicable law, the other provisions shall remain in force. In the case of Japan all agreements will be interpreted and enforced by the Tokyo District Court. 

 

1.13                           Enforcing this agreement: The Client must pay any reasonable and proper costs including legal fees that Regus incurs in enforcing this agreement. 

 

2. Services and Obligations  

 

2.1                                 Furnished office accommodation(s): Regus is to provide the number of serviced and furnished office accommodation(s) for which the Client has agreed to pay in the Center stated in this agreement. This agreement lists the accommodation(s) Regus has initially allocated for the Client’s use. The Client will have a non-exclusive right to the rooms allocated to it. Occasionally Regus may need to allocate different accommodation(s), but these accommodation(s) will be of reasonably equivalent size and Regus will notify the Client with respect to such different accommodation(s) in advance. 

 

2.2                                 Office Services: Regus is to provide during normal opening hours the services, if requested, described in the relevant service description (which is available on request). If Regus decides that a request for any particular service is excessive, it reserves the right to charge an additional fee. 

 

2.3                                 RegusNET: REGUS DOES NOT MAKE ANY REPRESENTATIONS AS TO THE SECURITY OF REGUS’ NETWORK (OR THE INTERNET) OR OF ANY INFORMATION THAT THE CLIENT PLACES ON IT. The Client should adopt whatever security measures (such as encryption) it believes are appropriate to its circumstances. Regus cannot guarantee that a particular degree of availability will be attained in connection with the Client’s use of Regus’ network (or the internet). The Client’s sole and exclusive remedy shall be the remedy of such failure by Regus within a reasonable time after written notice. 

 

3. Providing the Services  

 

3.1                                 Access to the accommodation(s): Regus may need to enter the Client’s accommodation(s) and may do so at any time. However, unless there is an emergency or the Client has given notice to terminate, Regus will attempt to notify the Client verbally or electronically in advance when Regus needs access to carry out testing, repair or works other than routine inspection, cleaning and maintenance. Regus will also endeavor to respect reasonable security procedures to protect the confidentiality of the Client’s business. 

 

3.2                                 Availability at the start of this agreement: If for any reason Regus cannot provide the accommodation(s) stated in this agreement by the date when this agreement is due to start it has no liability to the Client for any loss or damages but the Client may cancel this agreement without penalty. Regus will not charge the Client the monthly office fee for accommodation(s) the Client cannot use until it becomes available. Regus may delay the start date of this agreement provided it provides to the Client alternative accommodation(s) that shall be at least of equivalent size to the accommodation(s) stated in this agreement. 

 

4. Accommodation(s)  

 

4.1                                 The Client must not alter any part of its accommodation and must take good care of all parts of the Center, its equipment, fixtures, fittings and furnishings which you use. The Client is liable for any damage caused by it or those in the Center with the Client’s permission or at the Client’s invitation whether express or implied, including but not limited to all employees, contractors, agents or other persons present on the premises. 

 

4.2                                 Office furniture and equipment: The Client must not install any cabling, IT or telecom connections without Regus’ consent, which Regus may refuse at its absolute discretion. As a condition to Regus’ consent, the Client must permit Regus to oversee any installations (for example IT or electrical systems) and to verify that such installations do not interfere with the use of the accommodation(s) by other Clients or Regus or any landlord of the building. 

 

4.3                                 Insurance: It is the Client’s responsibility to arrange insurance for its own property which it brings in to the Center and for its own liability to its employees and to third parties. Regus strongly recommends that the Client put such insurance in place. 

 

5. Use  

 

5.1                                 The Client must only use the accommodation(s) for office purposes. Office use of a “retail” or “medical” nature, involving frequent visits by members of the public, is not permitted. 

 

5.2                                 The Client must not carry on a business that competes with Regus’ business of providing serviced office accommodation(s). 

 

5.3                                 The Client’s name and address: The Client may only carry on that business in its name or some other name that Regus previously agrees. 

 

5.4                                 Use of the Center Address: The Client may use the Center address as its business address. Any other uses are prohibited without Regus’ prior written consent. 

 

6. Compliance  

 

6.1                                 Comply with the law: The Client must comply with all relevant laws and regulations in the conduct of its business. The Client must do nothing illegal in connection with its use of the Business Center. The Client must not do anything that may interfere with the use of the Center by Regus or by others, cause any nuisance or annoyance, increase the insurance premiums Regus has to pay, or cause loss or damage to Regus (including damage to reputation) or to the owner of any interest in the building which contains the Center the Client is using. The Client acknowledges that (a) the terms of the foregoing sentence are a material inducement in Regus’ execution of this agreement and (b) any violation by the Client of the foregoing sentence shall constitute a material default by the Client hereunder, entitling Regus to terminate this agreement, without further notice or procedure. 

 

6.2                                 The Client’s personal data may be transferred outside the European Union where Regus has a Center for the purposes of providing the services herein. Regus has adopted internal rules to ensure data protection in accordance with European regulations. 

 

7. Regus’ Liability  

 

7.1.                              The extent of Regus’ liability: To the maximum extent permitted by applicable law, Regus is not liable to the Client in respect of any loss or damage the Client suffers in connection with this agreement, with the services or with the Client’s accommodation(s) unless Regus has acted deliberately or negligently in causing that loss or damage. Regus is not liable for any loss as a result of Regus’ failure to provide a service as a result of mechanical breakdown, strike, termination of Regus’ interest in the building containing the Center or otherwise unless Regus does so deliberately or is negligent. In no event shall Regus be liable for any loss or damage until the Client provides Regus written notice and gives Regus a reasonable time to put it right. If Regus is liable for failing to provide the Client with any service under this agreement then subject to the exclusions and limits set out immediately below Regus will pay any actual and reasonable expenses the Client has incurred in obtaining that service from an alternative source. If the Client believes Regus has failed to deliver a service consistent with these terms and conditions the Client shall provide Regus written notice of such failure and give Regus a reasonable period to put it right. 

 

7.2.                              EXCLUSION OF CONSEQUENTIAL LOSSES, ETC.: REGUS WILL NOT IN ANY CIRCUMSTANCES HAVE ANY LIABILITY FOR LOSS OF BUSINESS, LOSS OF PROFITS, LOSS OF ANTICIPATED SAVINGS, LOSS OF OR DAMAGE TO DATA, THIRD PARTY CLAIMS OR ANY CONSEQUENTIAL LOSS UNLESS REGUS OTHERWISE AGREES IN WRITING. REGUS STRONGLY ADVISES THE CLIENT TO INSURE AGAINST ALL SUCH POTENTIAL LOSS, DAMAGE, EXPENSE OR LIABILITY. 

 

7.3.                              Financial limits to Regus’ liability: In all cases, Regus’ liability to the Client is subject to the following limits:

 

·  Without limit for personal injury or death;

 

·  Up to a maximum of £1 million / USD$2 million / €1.3 million (or local equivalent) for any one event or series of connected events for damage to the Client’s personal property;

 

·  Up to a maximum equal to 125% of the total fees paid between the date the Client moved into its accommodation(s) and the date on which the claim in question arises or £50,000 / USD$100,000 / €66,000 (or local equivalent) whichever is the higher, in respect of any other loss or damage. 

 

8. Fees  

 

8.1                                 Taxes and duty charges: The Client agrees to pay promptly (i) all sales, use, excise, consumption and any other taxes and license fees which it is required to pay to any governmental authority (and, at Regus’ request, will provide to Regus evidence of such payment) and (ii) any taxes paid by Regus to any governmental authority that are attributable to the accommodation(s), including, without limitation, any gross receipts, rent and occupancy taxes, tangible personal property taxes, stamp tax or other documentary taxes and fees. 

 

8.2                                 Service Retainer/Deposit: The Client will be required to pay a service retainer/deposit equivalent to two months’ of the monthly office fee (plus VAT/Tax where applicable) upon entering into this agreement unless a greater amount is specified on the front of this agreement. This will be held by Regus without generating interest as security for performance of all the Client’s obligations under this agreement. The service retainer or any balance after deducting outstanding fees, three months VO fee for the Client’s VO agreement, and other costs due to Regus, will be returned to the Client after the Client has settled its account with Regus and funds have cleared. 

 

8.3                                 Regus may require the Client to pay an increased retainer if outstanding fees exceed the service retainer/deposit held and/or the Client frequently fails to pay Regus when due. 

 

8.4                                 The Client will be charged an office set up fee per occupant. Fee amounts are located in the House Rules which can be requested at any time. 

 

8.5                                 Late payment: If the Client does not pay fees when due, a fee will be charged on all overdue balances. This fee will differ by country and is listed in the House Rules. If the Client disputes any part of an invoice the Client must pay the amount not in dispute by the due date or be subject to late fees. Regus also reserves the right to withhold services (including for the avoidance of doubt, denying the Client access to its accommodation(s)) while there are any outstanding fees and/or interest or the Client is in breach of this agreement. 

 

8.6                                 Insufficient Funds: The Client will pay a fee for any returned check or any other declined payments due to insufficient funds. This fee will differ by country and is listed in the House Rules. 

 

8.7                                 Regus will increase the monthly office fee each and every anniversary of the start date of this agreement by a percentage amount equal to the increase in the All Items Retail Prices Index, or such other broadly equivalent index which Regus substitutes provided that if the foregoing increase is not permitted by applicable law, then the monthly office fee shall be increased as specified in the House Rules. This will only apply to agreements that have an original start and end date constituting more than a 12 month term. Renewals will be renewed as per clause 1.3 above and only those renewals with a start and end date constituting a term of over 12 months will have the same increase applied. 

 

8.8                                 Standard services: The monthly office fee and any recurring services requested by the Client are payable monthly in advance. Unless otherwise agreed in writing, these recurring services will be provided by Regus at the specified rates for the duration of this Agreement (including any renewal). Specific due dates will differ by country and are listed in the House Rules. Where a daily rate applies, the charge for any such month will be 30 times the daily fee. For a period of less than a month the fee will be applied on a daily basis. 

 

8.9                                 Pay-as-you-use and Additional Variable Services: Fees for pay-as-you-use services, plus applicable taxes, in accordance with Regus’ published rates which may change from time to time, are invoiced in arrears and payable the month following the calendar month in which the additional services were provided. Specific due dates will differ by country and are listed in the House Rules.

 

Global – Terms & Conditions – August 2009 - lveber

 

 

 

Addendum to Service Agreement

 

This Addendum to the Office Service Agreement is made by and between Regus Management Group, LLC (“Regus”) and TRANZYME (“Client”) and entered into on the 19 day of October, 2010, (“Addendum”).

 

Recitals

 

A.                                   Client and Regus are parties to that certain Office Service Agreement dated 10/19/2010 in which Regus provides certain services and facilities to you (“Agreement”).

 

B.                                     The parties desire to amend the terms of the Agreement under the following terms and conditions.

 

NOW, THEREFORE, for and in consideration of the mutual covenants and promises contained herein and other good and valuable considerations, the parties agree as follows:

 

1.          Amendment. The terms of the Agreement will be amended as follows:

 

1. Phone and Internet will be charged for 15 people or number of users, whichever is less. Volume discounts may apply for individual phone, phone line and internet charges or be priced at $199/user, whichever is less.

2. Beverage fee to be charged for 8 people at $30 each. Additional users added during the agreement term to be added at $30 each.

2. Domestic long distance to be billed at $0.11 per minute, long distance to Canada to be billed at $0.14 per minute

3. Color Prints and Copies discounted to $.55 per page.

4. Notice period will be 60 days instead of 90.

 

2.          Term. The Addendum shall automatically terminate on 11/30/2010, or such earlier termination of the Agreement.

 

3.          Control. Except as specifically modified or amended by the terms of this Addendum, the Agreement will remain in full force and effect. In the event of a conflict between this Addendum and the Agreement or any attachment thereto, this Addendum will control.

 

4.          Capitalized Terms. All capitalized terms not otherwise defined in this Addendum will have their respective meanings as set forth in the Agreement.

 

5.          General Terms. This Addendum may be executed in one or more counterparts and/or by facsimile, each of which will be deemed an original and all of which signed counterparts, taken together, will constitute one and the same instrument.

 

In Witness Whereof, the parties have executed this Addendum as of the date first above written.

 

 

	
Client:
  	
/s/ Richard I. Eisenstadt
  	
 
  	
Regus:
  
	
 
  	
 
  	
 
  
	
TRANZYME
  	
 
  	
Regus Management Group, LLC
  
	
 
  	
 
  	
 
  
	
 
  	
Richard I. Eisenstadt
  	
 
  	
Tara Wilson
  
	
Name
  	
 
  	
Name
  
	
 
  	
 
  	
 
  
	
 
  	
CFO
  	
 
  	
Center Manager
  
	
Title
  	
 
  	
Title
  
	
 
  	
 
  	
 
  
	
 
  	
22 Nov 2010
  	
 
  	
11/22/10
  
	
Date
  	
 
  	
Date
  

 

	
1000 locations   
  	
450 cities
  	
  75 countries
  	
 
  	
regus.com

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