Document:

Prepared by MerrillDirect

EXHIBIT 10.28

ASSET
PURCHASE AGREEMENT

By
and Between

INVITROGEN
CORPORATION

and

CIPHERGEN
BIOSYSTEMS, INC.

Dated
as of June 25, 2001

 

	1.	Sale and Delivery of
  the Assets
	 	 
	 	1.1	Delivery
  of the Assets
	 	1.2	Further
  Assurances
	 	1.3	Purchase Price
	 	1.4	Assumption of
  Liabilities; Etc
	 	1.5	Allocation of Purchase
  Price
	 	1.6	The Closing
	 	 	 
	2.	Representations of the
  Seller
	 	 
	 	2.1	Organization
	 	2.2	Capitalization of BSA and
  BSG
	 	2.3	Authorization;
  Consents and Approvals; No Violations
	 	2.4	Ownership and
  Condition of the Assets
	 	2.5	Reports and Financial
  Statements
	 	2.6	Absence of
  Undisclosed Liabilities
	 	2.7	Litigation
	 	2.8	Inventory
	 	2.9	Fixed Assets
	 	2.10	Leases
	 	2.11	Change in
  Financial Condition and Assets
	 	2.12	Tax Matters
	 	2.13	Accounts
  Receivable
	 	2.14	Contracts and Commitments
	 	2.15	Compliance with
  Agreements and Laws
	 	2.16	Employee Relations
  and Benefit Plans
	 	2.17	Customers
	 	2.18	Suppliers
	 	2.19	Names and
  Other Intangible Property
	 	2.20	Real Estate
	 	2.21	Powers of
  Attorney
	 	2.22	Brokers
	 	2.23	No Illegal or
  Improper Transactions
	 	2.24	Environmental
  Matters
	 	2.25	Product Warranties;
  Liabilities
	 	2.26	Bankruptcy
	 	2.27	Insurance
	 	2.28	Books and
  Records
	 	 	 
	3.	Representations of the
  Buyer
	 	 	 
	 	3.1	Organization and Authority
	 	3.2	Authorization
	 	3.3	No
  Conflicts; Consents
	 	3.4	Brokers
	 	 	 
	4.	Access
  to Information; Confidentiality; Public Announcements
	 	 	 
	 	4.1	Access
  to Management, Properties and Records
	 	4.2	Confidentiality
	 	4.3	Public
  Announcements
	 	 	 
	5.	Pre-Closing
  Covenants of the Seller
	 	 
	 	5.1	Conduct
  of Business
	 	5.2	Absence of Material Changes
	 	5.3	Taxes
	 	5.4	Communication
  with Customers and Suppliers
	 	5.5	Compliance
  with Laws
	 	5.6	Continuing Obligation
  to Inform
	 	 	 
	6.	Reasonable
  Best Efforts to Obtain Satisfaction of Conditions
	 	 
	7.	Employment
  Matters
	 	 
	8.	Conditions to
  Obligations of the Buyer
	 	 	 
	 	8.1	Continued
  Truth of Representations and Warranties of the Seller; Compliance with
  Covenants and Obligations
	 	8.2	Corporate
  Proceedings
	 	8.3	Consents
  of Third Parties
	 	8.4	Adverse
  Proceedings
	 	8.5	Update
	 	8.6	Closing
  Deliveries
	 	8.7	Closing
  Balance Sheet
	 	8.8	Collaboration
  Agreement
	 	8.9	Opinion
  of Works Council
	 	8.10	Governmental
  Approvals
	 	 	 
	9.	Conditions to
  Obligations of the Seller
	 	 	 
	 	9.1	Continued Truth of
  Representations and Warranties of the Buyer; Compliance with Covenants and
  Obligations
	 	9.2	Corporate
  Proceedings
	 	9.3	Consents of Third Parties
	 	9.4	Adverse
  Proceedings
	 	9.5	Closing
  Deliveries
	 	9.6	Collaboration
  Agreement
	 	9.7	Opinion
  of Works Council
	 	9.8	Governmental
  Approvals
	 	 	 
	10.	Termination
  of Representations and Warranties
	 	 	 
	11.	Post-Closing
  Agreements
	 	 	 
	 	11.1	Proprietary
  Information
	 	11.2	No
  Solicitation or Hiring of Former Employees
	 	11.3	Non-Competition Agreement
	 	11.4	Use of Name
	 	11.5	Cooperation in Litigation
	 	11.6	Access to Books and Records
	 	11.7	Intangible Property
  Cooperation
	 	11.8	Beckman
  Obligations
	 	 	 
	12.	Termination
  of Agreement
	 	 
	 	12.1	Termination by Lapse of
  Time
	 	12.2	Termination by
  Agreement of the Parties
	 	12.3	Termination
  by Buyer or Seller By Reason of Breach
	 	12.4	Effect
  of Termination
	 	 	 
	13.	Fees and
  Expenses
	 	 	 
	14.	Indemnification
	 	 
	 	14.1	Survival of
  Representations and Warranties
	 	14.2	Indemnification
  Provisions for Benefit of Buyer
	 	14.3	Indemnification
  Provisions for Benefit of Seller
	 	14.4	Matters Involving Third
  Parties
	 	14.5	Adjustments to
  Indemnification Payments
	 	14.6	Mitigation
  of Loss
	 	14.7	Remedies
	 	 	 
	15.	Transfer
  and Sales Tax
	 	 
	16.	Notices
	 	 	 
	17.	Successors
  and Assigns
	 	 	 
	18.	Entire
  Agreement; Amendments; Attachments
	 	 	 
	19.	Governing Law
	 	 	 
	20.	Section Heading
	 	 	 
	21.	Severability
	 	 	 
	22.	Counterparts
	 	 	 
	23.	No Third Party
  Beneficiaries
	 	 	 
	24.	Translations

INDEX
OF EXHIBITS

Exhibit
A          Instrument of Assumption

Exhibit B           Current Balance Sheet

Exhibit
C           Bill of Sale

Exhibit D           Beckman
Obligations

Exhibit
E           Bill of Sale

INDEX
OF SCHEDULES

	SCHEDULE
  1.1 (b)(i)	Excluded
  Assets
	SCHEDULE
  1.4 (a)(i)	Assumed
  Liabilities/Accounts, Accounts Payable and Accrued Expenses
	SCHEDULE
  1.4 (a)(ii)	Assumed
  Liabilities/Contracts
	SCHEDULE
  1.4 (a)(iii)	Assumed
  Liabilities /Other Liabilities and Obligations
	SCHEDULE
  1.5	Allocation
  of Purchase Price
	SCHEDULE
  2.3	Consents
  and Approvals
	SCHEDULE
  2.4(a)	Ownership
  and Condition of the Assets/Encumbrances
	SCHEDULE
  2.4(b)	Ownership
  of the Assets/Permitted Encumbrances
	SCHEDULE
  2.6	Absence
  of Undisclosed Liabilities
	SCHEDULE
  2.7	Litigation
	SCHEDULE
  2.8	Inventory
	SCHEDULE
  2.9	Fixed
  Assets
	SCHEDULE
  2.10	Leases
	SCHEDULE
  2.11	Change
  in Financial Condition and Assets
	SCHEDULE
  2.12	Tax
  Matters
	SCHEDULE
  2.13	Accounts
  Receivable
	SCHEDULE
  2.14	Contracts
  and Commitments
	SCHEDULE
  2.15	Compliance
  with Agreements and Laws
	SCHEDULE
  2.16(a)	Employees
	SCHEDULE
  2.16(b)	Employee
  Relations and Benefit Plans
	SCHEDULE
  2.17	Customers
	SCHEDULE
  2.18	Suppliers
	SCHEDULE
  2.19(a)	Intangible
  Property
	SCHEDULE
  2.19(b)	Non-Exclusive
  Intangible Property
	SCHEDULE
  2.19(c)	Names
	SCHEDULE
  2.21	Powers
  of Attorney
	SCHEDULE
  2.27	Insurance
  Policies
	SCHEDULE
  3.2	Consents
  and Approvals

ASSET PURCHASE AGREEMENT

             Asset Purchase Agreement (this “Agreement”) made as of
the 25th day of June, 2001 by and between Invitrogen Corporation, a Delaware
corporation with its principal office at 1600 Faraday Avenue, Carlsbad,
California 92008 (the “Seller”), and Ciphergen Biosystems, Inc., a Delaware
corporation with its principal office at 6611 Dumbarton Circle, Fremont,
California  94555 (the “Buyer”).

Preliminary Statement

             The Buyer desires to purchase, and the Seller desires to
sell, the business of the Seller which is conducted under the name “BioSepra”,
including but not limited to the manufacture and sale of chromatographic media
for process scale chromatographic purification of proteins (including any such
business conducted through subsidiaries) (collectively, the “Business”), together
with substantially all of the assets held directly or indirectly by Seller
solely for use in the Business, for the consideration set forth below and the
assumption of certain of the Seller’s liabilities set forth below, subject to
the terms and conditions of this Agreement.

             NOW, THEREFORE, in consideration of the mutual promises
hereinafter set forth and for other good and valuable consideration, the
receipt and sufficiency of which are hereby acknowledged, the parties hereby
agree as follows:

             1.          Sale and Delivery of the
Assets.

                           1.1        Delivery of the Assets.

                                        (a)         Subject to and upon the terms and conditions of this
Agreement, at the closing of the transactions contemplated by this Agreement
(the “Closing”), the Seller shall sell, transfer, convey, assign and deliver to
the Buyer, and the Buyer shall purchase from the Seller, the following
properties, assets and other claims, rights and interests of the Seller which
relate to or are used or held for use solely in connection with the Business:

                                                     (i)          all inventories of finished goods and
packaging materials and similar items of the Seller which exist on the Closing
Date (as defined below);

                                                     (ii)         all prepaid expenses, advance payments
and security deposits existing on the Closing Date;

                                                     (iii)        all rights and benefits under the
Contracts (as defined below) set forth on Schedule 2.14 attached hereto
(collectively, the “Assumed Contracts”);

                                                     (iv)       all operating data and records, including
without limitation, books (other than corporate minute and stock record books),
records and accounts, correspondence, research and development files, drug
master files, production records, technical, accounting, manufacturing, quality
control and procedural manuals, customer lists, customer complaint files, sales
and marketing literature, purchase orders and invoices and employment records;

                                                     (v)        all of Seller’s right, title and
interest in and to all of the outstanding shares of capital stock, with any
dividends pertaining to the 2001 fiscal year and all subsequent fiscal years
attached, of BioSepra, S.A. (the “BSA Shares”), a subsidiary of the Seller
(“BSA”);

                                                     (vi)       all of Seller’s right, title and interest
in and to the intangible property which is listed on Schedule 2.19(a)
attached hereto (collectively, the “Intangible Property”);

                                                     (vii)      the name and all goodwill associated with
the name “BioSepra” and all other tradenames and trademarks of Seller used
solely in the Business, including without limitation all of Seller’s right,
title and interest in the Intangible Property listed on Schedule 2.19(a);

                                                     (viii)     the toll-free telephone number
(800) 752–5277;

                                                     (ix)        all rights to the Internet website
address http://www.biosepra.com;

                                                     (x)         all rights, claims, warranty rights or
other similar rights of the Seller, under express or implied warranties from
suppliers;

                                                     (xi)        all non-competition agreements in favor
of the Seller; and

                                                     (xii)       except as provided in Section 1.1(b)
hereof,  all other assets, properties,
claims, rights and interests of the Seller which exist on the Closing Date, of
every kind and nature and description, whether tangible or intangible, real,
personal or mixed, wherever located, which relate to or are used or held for
use solely in connection with the Business.

                                        (b)        Notwithstanding the provisions of paragraph (a) above, the
assets, properties, claims, rights and interests of Seller to be transferred to
the Buyer under this Agreement shall not include (i) those assets of the Seller
listed on Schedule 1.1(b)(i) attached hereto; or (ii) any Contracts to
which the Seller is a party or by which it is bound, other than the Assumed
Contracts ((i) and (ii) together, the “Excluded Assets”).

                                        (c)         The Assumed Contracts, BSA Shares, Intangible Property and
other properties, assets and business of the Seller described in paragraph (a)
above, other than the Excluded Assets, shall be referred to collectively as the
“Assets.”

 

                           1.2        Further Assurances. 
At any time and from time to time after the Closing, at the Buyer’s request,
the Seller promptly shall execute and deliver such instruments of sale,
transfer, conveyance, assignment and confirmation, and take such other action
as the Buyer may reasonably request to transfer, convey and assign to the
Buyer, and to confirm the Buyer’s title to, all of the Assets, to put the Buyer
in actual possession and operating control thereof, to assist the Buyer in
exercising all rights with respect thereto and to carry out the purpose and
intent of this Agreement. Without limiting the generality of the foregoing, the
Seller shall execute such applications to governmental authorities, consents
and other documents and take such other action
as Buyer may reasonably request in order to enable the Buyer to use and
register, as the Buyer may desire, the name “BioSepra” and any variation
thereof and all other tradenames and trademarks of Seller used solely in the
Business.

             From time to time after the Closing, but on no less than
a monthly basis, (a) the Buyer shall pay to the Seller any amount of cash or
other remittances received by it from accounts receivable of the Seller or
which the Buyer is not otherwise entitled under the provisions of this
Agreement to retain and (b) the Seller shall pay to the Buyer any amount of any
cash or other remittances received by it from accounts receivable of BSA or
which the Seller is not otherwise entitled under the provisions of this
Agreement to retain.

                           1.3        Purchase Price.

                                        (a)         The purchase price for the Assets shall be Twelve Million
Dollars ($12,000,000.00) plus the amount of the Assumed Liabilities (as defined
herein), as determined and adjusted pursuant to this Agreement (the “Purchase
Price”). At the Closing, the Buyer shall deliver to the Seller the aggregate
sum of Twelve Million Dollars ($12,000,000.00), (i) less the amount of any
downward adjustments made pursuant to Section 1.3(b) and (ii) plus the amount
of any upward adjustments made pursuant to Section 1.3(b), payable by wire
transfer of immediately available funds to an account designated by the Seller.

                                        (b)        On the Closing Date, the Seller shall deliver to the Buyer
(1) the most recently available month-end combined balance sheet of the Seller
relating to the Business and of BSA and BSG (as defined herein) certified by
the Vice President—Finance of the Seller (the “Closing Balance Sheet”) and (2)
a certificate of the Vice President—Finance of the Seller certifying the amount
of cash and cash equivalents of BSA (the “Cash Amount”) as of the Closing Date
(the “Closing Cash Certificate”).  The
Closing Balance Sheet shall be prepared on a basis consistent with that of the
Current Balance Sheet (as defined below). 
Except as set forth on the Closing Balance Sheet or as described in the
notes thereto, the Closing Balance Sheet shall be prepared in accordance with
United States generally accepted accounting principles (“GAAP”) applied on a
consistent basis.

                                                     (i)          If net assets as set forth on the
Closing Balance Sheet (“Closing Net Assets”) are less than Five Million Four
Hundred Twenty Two Thousand One Hundred Two Dollars ($5,422,102.00) (the “Net
Assets Target Amount”), the amount of the Purchase Price to be paid to the
Seller in cash at the Closing will be reduced on a dollar-for-dollar basis by
the amount of such deficiency, and if the Closing Net Assets are more than the
Net Assets Target Amount, the amount of the Purchase Price to be paid to the
Seller in cash at the Closing will be increased on a dollar-for-dollar basis by
the amount of such excess.

                                                     (ii)         The amount of the Purchase Price to be
paid to the Seller in cash at the Closing will be increased on a
dollar-for-dollar basis by the Cash Amount set forth on the Closing Cash
Certificate.

                                        (c)         No later than 60 days after the Closing Date, the Seller
shall deliver to the Buyer (1) a combined balance sheet of the Seller relating
to the Business and of BSA and BSG as of the Closing Date certified by the Vice
President – Finance of the Seller to be true, correct and complete (the
“Closing Date Balance Sheet”), (2) a certificate of the Vice President—Finance
of the Seller certifying the Cash Amount as of the Closing Date (the “Closing
Date Cash Certificate”) and (3) a true, correct and complete list and amount,
as of the Closing Date, of each item referenced in Section 8.5 hereof.  Except as set forth on the Closing Date
Balance Sheet or as described in the notes thereto, the Closing Date Balance
Sheet shall be prepared in accordance with GAAP applied on a consistent
basis.  The Closing Date Balance Sheet
shall be prepared on a basis consistent with that of the Current Balance Sheet,
except as described in Section 1.3(d) below.

                                        (d)        There shall be recorded on the Closing Date Balance Sheet an
asset or liability, as the case may be, for the net Intercompany Accounts (as
defined below), which asset or liability shall be taken into account in
determining net assets on the Closing Date Balance Sheet.  In addition, net assets as set forth on the
Closing Date Balance Sheet shall be subject to further adjustment as follows
(net assets as set forth on the Closing Date Balance Sheet and as further
adjusted pursuant to this Section 1.3(d) being referred to as the “Closing Date
Net Assets”):  (i) if net Intercompany
Accounts results in an asset on the Closing Date Balance Sheet, net assets as
set forth on the Closing Date Balance Sheet shall be reduced by the amount of
such asset; or (ii) if net Intercompany Accounts results in a liability on the
Closing Date Balance Sheet, net assets as set forth on the Closing Date Balance
Sheet shall be increased by the amount of such liability.  “Intercompany Accounts” shall mean all
amounts that are (a) owed by BSA or BSG to the Seller or any of its direct or
indirect subsidiaries (other than BSA or BSG) or (b) owed by the Seller or
any of its direct or indirect subsidiaries (other than BSA or BSG) to BSA or
BSG, in each case pursuant to bona fide obligations.

                                        (e)         No later than 60 days after delivery of the Closing Date
Balance Sheet and the Closing Date Cash Certificate, the Buyer shall complete a
review thereof and shall inform the Seller in writing that the Closing Date
Balance Sheet and the Closing Date Cash Certificate are acceptable or shall
object thereto in writing setting forth a specific description of the Buyer’s
objections.  If the Buyer objects to the
Closing Date Balance Sheet or the Closing Date Cash Certificate and the Seller
does not agree with the Buyer’s objections or such objections are not resolved
on a mutually agreeable basis within 30 days of the Seller’s receipt of Buyer’s
objections, any such disagreement shall be promptly submitted to a mutually
acceptable “big five” accounting firm that is unaffiliated with either party or
that is acceptable to Buyer and Seller (the “Unaffiliated Firm”). The
Unaffiliated Firm shall resolve such dispute within 30 days after said Unaffiliated
Firm’s engagement by the parties. The decision of such Unaffiliated Firm shall
be final and binding upon the Seller and the Buyer and its fees, costs and
expenses shall be borne by the party against whom the Unaffiliated Firm shall
rule.

                                        (f)         If Closing Date Net Assets as set forth on the Closing Date
Balance Sheet as finally determined pursuant to the preceding paragraph are
more or less than the Net Assets Target Amount, the Purchase Price will be
increased or decreased, respectively, and the Buyer or the Seller, as the case
may be, will pay to the other cash in an amount equal to such excess or
deficiency, taking into account any adjustments previously made pursuant to
subparagraph (b)(i) above.  Likewise, if
the Cash Amount as set forth on the Closing Date Cash Certificate as finally
determined pursuant to the preceding paragraph is more or less than the amount
set forth on the Closing Cash Certificate, the Purchase Price will be increased
or reduced, respectively, and the Buyer or the Seller, as the case may be, will
pay to the other cash in an amount equal to such excess or deficiency.  Any payments pursuant to this paragraph
shall be made within 10 business days of determination by wire transfer of
immediately available funds to an account specified by the Buyer or the Seller,
as the case may be.

                                        (g)        All Intercompany Accounts will be deemed fully paid and
discharged as of the Closing Date through the adjustments to the Purchase Price
set forth in Section 1.3(f) above which, as between the Seller and its direct
or indirect subsidiaries (other than BSA or BSG), on the one hand, and BSA and
BSG, on the other hand, shall constitute a final settlement of all such
Intercompany Accounts.  Following the
Closing, each of the Seller and the Buyer shall be responsible for settling all
Intercompany Accounts with their respective subsidiaries.

                           1.4        Assumption of
Liabilities; Etc.

                                        (a)         At the Closing, on the terms and subject to the conditions
of this Agreement, the Buyer shall execute and deliver an Instrument of
Assumption of Liabilities (the “Instrument of Assumption”) substantially in the
form attached hereto as Exhibit A, pursuant to which it shall assume and
agree to perform, pay and discharge in accordance with their terms the
following liabilities, obligations and commitments of the Seller which relate
to the Business or the Assets:

                                                     (i)          Those accounts, accounts payable and
accrued expenses of Seller which are set forth on Schedule 1.4(a)(i) attached
hereto;

                                                     (ii)         All obligations of the Seller
continuing after the Closing under the Assumed Contracts which become due and
payable or are required to be performed after the Closing Date; and

                                                     (iii)        Those other liabilities and obligations
of the Seller which relate to the Business or the Assets which are specifically
set forth on Schedule 1.4(a)(iii) attached hereto. The foregoing
liabilities and obligations are collectively referred to as the “Assumed
Liabilities.”

                                        (b)        The Seller shall be responsible for and satisfy any and all
of the liabilities, obligations and commitments of the Seller not assumed by
Buyer pursuant to Section 1.4(a) hereof (the “Excluded Liabilities”). Without
limiting the foregoing, Buyer shall not assume, pay or discharge, and shall not
be liable for any liability, commitment or expense of Seller as a result of or
arising from any of the following:

                                                     (i)          Seller’s obligations and liabilities
arising under this Agreement;

                                                     (ii)         any liability of the Seller for Taxes
(as defined in Section 2.12) arising from the operation of the Business on or
prior to the Closing Date or arising out of the sale by the Seller of the
Assets pursuant to this Agreement other than with respect to Taxes or charges
as set forth in Section 15 below;

                                                     (iii)        all accounting, consulting, finders, investment
banking, legal and similar fees and expenses incurred by the Seller in
connection with the negotiation of this Agreement and the consummation of the
transactions contemplated hereby;

                                                     (iv)       any liabilities or obligations of Seller
under any contracts, commitments, arrangements or agreements relating solely to
the Excluded Assets;

                                                     (v)        any liability or obligation, including,
without limitation, any liability for the Seller’s attorney’s fees or expenses,
resulting from litigation, if any, which results from the circumstances
disclosed in Schedule 2.7; and

                                                     (vi)       any infringement or alleged infringement
of any patent, trademark, trade name, copyright or other property right of any
other person or entity arising out of any action of Seller on or prior to the
Closing Date or any misappropriation or misuse of any trade secret or
confidential or proprietary invention, discovery, process, formula, know-how,
technology or information or any other right of another person or entity
arising out of any action of Seller on or prior to the Closing Date.

                           1.5        Allocation of Purchase
Price. 
The aggregate amount of the Purchase Price shall be allocated among the Assets
for all purposes (including Tax and financial accounting purposes) in form and
substance to be mutually agreed upon by Buyer and Seller, provided that the
amount of the Purchase Price allocated to the BSA Shares shall not be less than
$6,805,674.00. The parties shall file all Tax Returns (as defined in Section
2.12(a) hereof) in a manner consistent with such allocation; provided, however, that if any
taxing authority makes or proposes an allocation with respect to the Assets
which differs materially from such allocation, each of the Buyer and the Seller
shall have the right, at its election and expense, to contest such taxing
authority’s determination. In the event of such a contest, the other party
agrees to cooperate reasonably with the contesting party and shall have the
right to file such protective claims or returns as may be reasonably required
to protect its interest. Each party shall provide the other party with all
notices and information reports filed with taxing authorities and agencies with
respect to the allocation of the Purchase Price.

                           1.6        The Closing. 
The Closing shall take place at the offices of Fulbright & Jaworski L.L.P.,
801 Pennsylvania Avenue North West, Washington, D.C. at 10:00 a.m., Eastern
Standard Time, on July 27, 2001 or at such other place, time or date as
may be mutually agreed upon by the parties hereto. The transfer of the Assets
by the Seller to the Buyer shall be deemed to occur at the close of business,
Washington, D.C. time, on the date of the Closing (the “Closing Date”).

             2.           Representations of the
Seller.

             The Seller represents and warrants to the Buyer as follows,
except as set forth on the Disclosure Schedules attached hereto.  Disclosure on any Schedule hereto of an item
in response to one section of this Agreement shall constitute disclosure in
response to every section of this Agreement, notwithstanding the fact that no
cross-reference is made; provided, however, only if it is reasonably apparent
on the face of the listing that the listed item is such a responsive
matter.  Disclosure of any item not
otherwise required to be disclosed shall not create any inference of
materiality.  To the extent that a
representation or warranty set forth below is by its language made subject to a
knowledge or awareness qualifier, such representation and warranty means the
actual knowledge or awareness as of the date of execution of this Agreement of
any officer of Seller, BSA or BSG involved in the Business.

                           2.1        Organization. 
The Seller is a corporation duly organized, validly existing and in good
standing under the laws of the State of Delaware, and has all requisite power
and authority (corporate and other) to own its properties, to carry on its
business, including the Business, as now being conducted, to execute and
deliver this Agreement and the agreements contemplated herein, and to
consummate the transactions contemplated hereby and thereby. BSA is a French societe anonyme duly organized, validly
existing, and duly registered with the “Registre de Commerce et des Societes de
Pontoise” under the number B331502641 and has all requisite power and authority
to own its properties and to carry on its business as now being conducted.
BioSepra GmbH (“BSG”) is a German corporation duly organized, validly existing
and duly registered with the Commercial Register of the Local Court
(Amtsgericht), Frankfurt am Main, under No. HRB 39846. The Seller, BSA and BSG
are each duly qualified to do business and in good standing in all
jurisdictions in which their ownership or leasing of property or the character
of their business requires such qualification, except where the failure to be so
qualified or in good standing would not have a Material Adverse Effect (as
defined herein).  For purposes of this
Agreement, the term “Material Adverse Effect” means an effect which is, or
would reasonably be expected to be, materially adverse to the Business or the
Assets, taken as a whole.  Copies of the
bylaws, share transfer register (“registre
des mouvements de titres”), shareholder accounts (“comptes d’actionnaires”) and “extrait K-bis” of BSA and copies of the
Articles of Incorporation of BSG, each as amended to date, have been previously delivered to the Buyer, are
complete and correct, and no amendments have been made thereto or have been
authorized since the date thereof.

                           2.2        Capitalization of BSA
and BSG. 
BSA has a share capital of FF 21,300,000 divided into 213,000 shares of FF 100
each. All of such shares have been duly and validly issued, are fully paid and
nonassessable and are held of record and beneficially by the Seller, except
that six shares are held of record by minority shareholders in accordance with
requirements of French law and will be transferred to the Seller prior to the
Closing. BSG has a share capital of DM350,000 (the “BSG Shares”).  All of such BSG Shares have been duly and
validly issued and are fully paid and nonassessable.  The Seller owns the BSA Shares owned by it on the date hereof and
will, at the Closing, own all of the BSA Shares, free and clear of all
Encumbrances (as herein defined).  BSA
owns all of the BSG Shares on the date hereof and will, at the Closing, own all
of the BSG Shares, free and clear of all Encumbrances.  None of the BSA Shares or the BSG Shares
were issued in violation of any preemptive rights, rights of first refusal or
similar rights.  There are no
outstanding options, warrants, convertible securities, calls, rights,
commitments, preemptive rights, agreements, instruments or understandings of
any character to which the Seller, BSA or BSG is a party or by which the
Seller, BSA or BSG is bound, obligating Seller, BSA or BSG to issue, deliver or
sell, or cause to be issued, delivered or sold, contingently or otherwise,
additional shares of capital stock of BSA or BSG or any securities or
obligations convertible into or exchangeable for such shares or to grant,
extend or enter into any such option, warrant, convertible security, call,
right, commitment, preemptive right or agreement. There are no outstanding
obligations, contingent or otherwise, to which the Seller, BSA or BSG is a
party or by which the Seller, BSA or BSG is bound, obligating Seller, BSA or BSG
to purchase, redeem or otherwise acquire any capital stock of BSA or BSG,
including the BSA Shares and the BSG Shares. None of the Seller, BSA or BSG is
a party to any voting trust agreement or other contract, agreement,
arrangement, commitment, plan or understanding restricting transfer or
otherwise relating to voting, dividend or other rights with respect to the
capital stock of BSA or BSG, including the BSA Shares and the BSG Shares. BSA
does not have, directly or indirectly, any legal or beneficial interest in any
subsidiary, partnership, joint venture or other entity, other than BSG. BSG has
not (i) entered into any agreements, contracts, guarantees, understandings or
other commitments (written or oral), (ii) engaged in any commercial operations,
or (iii) incurred any liabilities or become subject to any obligations of any
nature (matured or unmatured, fixed or contingent).

                           2.3        Authorization; Consents and
Approvals; No Violations. 
(a)  The execution and delivery of this
Agreement by the Seller, and the agreements provided for herein, and the
consummation by the Seller of all transactions contemplated hereby and thereby,
have been duly authorized by all requisite corporate action.  This Agreement has been, and each other
agreement contemplated hereby to which the Seller is a party will be, duly
executed and delivered by the Seller. This Agreement and all such other
agreements and obligations entered into and undertaken in connection with the
transactions contemplated hereby to which the Seller is a party constitute or
will, when executed and delivered, constitute the valid and legally binding
obligations of the Seller, enforceable against the Seller in accordance with
their respective terms.

                                        (b)        Assuming that all consents, approvals, authorizations and
other actions described in this Section 2.3 or listed on Schedule 2.3
attached hereto have been obtained and all filings and obligations described in
this Section 2.3 or listed on Schedule 2.3 attached hereto have been
made, the execution and delivery of this Agreement do not, and the consummation
of the transactions contemplated hereby and compliance with the provisions
hereof will not, result in any violation of, or default (with or without notice
or lapse of time, or both) under, or give to others a right of termination,
cancellation or acceleration of any obligation or result in the loss of a
material benefit under, or result in the creation of any Encumbrance upon any
of the Assets or any of the properties or assets of BSA or BSG under, any
provision of (i) the Certificate of Incorporation or the Bylaws of Seller, as
amended to date, (ii) any provision of the comparable charter or organization
documents of each of BSA and BSG, each as amended to date, (iii) any loan or
credit agreement, note, bond, mortgage, indenture, lease or other agreement,
instrument, permit, concession, franchise or license to which Seller, BSA or
BSG is a party or to which Seller, BSA or BSG is bound (iv) any judgment,
order, decree, statute, law, rule or regulation applicable to Seller, BSA or
BSG, the Assets or any of the properties or assets of BSA or BSG, other than,
in the case of clauses (ii), (iii) or (iv), any such violations, defaults,
rights, losses, or Encumbrances that, individually or in the aggregate, would
not have a Material Adverse Effect, materially impair the ability of Seller to
perform its obligations hereunder or prevent the consummation of any of the
transactions contemplated hereby.

                                        (c)         No filing or registration with, or authorization, consent or
approval of, any United States (federal and state), foreign or supranational
court, commission, governmental body, regulatory agency, authority or tribunal
(a “Governmental Entity”) is required by or with respect to Seller, BSA
or BSG in connection with the execution and delivery of this Agreement by
Seller, or is necessary for the consummation of the transactions contemplated
by this Agreement, except (i) applicable requirements, if any, of applicable
securities laws or the Nasdaq Stock Market, and (ii) such other consents,
orders, authorizations, registrations, approvals, declarations and filings the
failure of which to be obtained or made would not, individually or in the
aggregate, have a Material Adverse Effect, materially impair the ability of Seller
to perform its obligations hereunder or prevent the consummation of any of the
transactions contemplated hereby.

                           2.4        Ownership and Condition
of the Assets. 
Schedule 2.4(a) attached hereto sets forth a true, correct and complete
list of all liens, mortgages, security interests, restrictions, pledges,
charges and encumbrances (collectively, the “Encumbrances”) affecting the
Assets or the Business. The Seller, BSA or BSG is, and at the Closing will be,
the true and lawful owner of or will have valid and subsisting leasehold
interests in or valid licenses to use, all of the Assets and all other assets
used or held for use in connection with the Business, and upon payment therefor
by Buyer, Buyer will have good and marketable title thereto, or valid and subsisting
leasehold interests in or valid licenses to use such assets free and clear of
all Encumbrances of any kind, except for those created by Buyer and except as
set forth on Schedule 2.4(b) attached hereto (the “Permitted
Encumbrances”). The Assets and the assets of BSA and BSG, taken as a whole,
constitute all the properties and assets relating to or used or held for use
solely in connection with the Business during the past 12 months (except
inventory sold, cash used in the Business, accounts receivable collected,
prepaid expenses realized, contracts fully performed, properties or assets
replaced by equivalent or superior properties or assets, in each case in the
ordinary course of the Business, and Excluded Assets).  Except for the Excluded Assets, there are no
assets or properties used solely in the conduct of the Business and owned by
any person or entity other than the Seller or BSA or BSG that will not be
leased or licensed to the Buyer under valid, current leases or licenses
following the Closing. The Assets and all assets of BSA and BSG are in adequate
operating condition and are adequate for the purposes for which they are
currently used or held for use.  To the
knowledge of the Seller, there are no facts or conditions affecting the Assets
which could, individually or in the aggregate, reasonably be expected to
interfere in any material respect with the use, occupancy or operation thereof
as currently used, occupied or operated, or their adequacy for such use,
occupancy or operation.

                           2.5        Reports and Financial
Statements. 
The Seller has made available to the Buyer true, correct and complete copies of
the audited accounts of BSA relating to the financial years ended December 31,
1998, 1999 and 2000, together with the Annexes thereto (the “BSA Accounts”).
The BSA Accounts have been prepared on the basis of a going concern and conform
to the French “Plan Comptable”; they
fairly present BSA’s financial position and of its results of operations and
cash flows for the relevant date and financial year.  The BSA Accounts make appropriate provision for bad or doubtful
debts and for the depreciation of Inventory. 
Neither the Seller nor BSA has received a written notice from an
official body or from its auditors concerning a failure to observe legal
requirements relating to the preparation of the BSA Accounts.  The preparation of the BSA Accounts has not
been subject to any significant change as to the accounting methods, principles
or practices used by BSA and/or Seller, or to a specific accounting
practice (in particular, without limitation, in respect of the accounting
principles, the notes to the accounts relating to reserves, to depreciation and
to rates used), which would otherwise give a misleading comparison between the
accounts for one period and the next.

                           2.6        Absence of Undisclosed
Liabilities. 
Attached hereto as Exhibit B is a true, correct and complete copy of the
unaudited combined balance sheet of Seller relating to the Business and of BSA
and BSG as of December 31, 2000 (the “Current Balance Sheet”).  The Current Balance Sheet is in accordance
with the books and records of the Seller, BSA and BSG and was prepared in
accordance with GAAP applied on a consistent basis throughout the periods
covered thereby (except as may be indicated therein or in the notes
thereto).  Seller does not have any
liability or obligation, secured or unsecured, whether accrued, absolute,
contingent, unasserted or otherwise, affecting the Assets or the Business, and
BSA and BSG do not have any liability or obligation, secured or unsecured,
whether accrued, absolute, contingent, unasserted or otherwise, except as and
to the extent with respect to any of the foregoing (a) reflected and reserved
against in the Current Balance Sheet, (b) incurred in the ordinary course of the
Business after the date of the Current Balance Sheet (none of which
individually or in the aggregate would have a Material Adverse Effect) or (c)
set forth on Schedule 2.6 attached hereto.  Except as disclosed on the Current Balance Sheet, as required by French
law or as disclosed on Schedule 2.6, none of the employees of the Business is now, or will by
passage of time hereafter become, entitled to receive any vacation time,
vacation pay or severance pay attributable to services rendered prior to
December 31, 2000.

                           2.7        Litigation. 
Except as set forth on Schedule 2.7 attached hereto, none of the Seller
(only to the extent related to the Business), BSA or BSG or any of their
respective officers or directors (in their capacity as such and only to the
extent related to the Business), is a party to, nor to the Seller’s knowledge
threatened with, and none of the Assets or any of the assets or properties of
BSA or BSG is subject to, any litigation, suit, action, investigation,
proceeding or controversy before any court, administrative agency or other
governmental authority, whether at common law, civil law or in equity nor to
Seller’s knowledge is there any basis therefor.

                           2.8        Inventory. 
Schedule 2.8 attached hereto sets forth a true, correct and complete
list of all inventories of finished goods and packaging materials and  similar items of Seller and its subsidiaries
other than BSA and BSG which relate to or are used or held for use solely in
connection with the Business and all other inventory of the Business of BSA and
BSG as of December 31, 2000 (the “Balance Sheet Date”), including raw
materials, works in progress, goods supplied to BSA or BSG by suppliers, goods
on consignment, office supplies, maintenance supplies, and all other goods
customarily sold by BSA or BSG (whether located on any of their respective
premises, in transit to or from such premises, in other storage facilities, or
otherwise), and Schedule 2.8 identifies whether such inventory is owned
by Seller, Seller’s affiliates other than BSA and BSG, BSA or BSG
(collectively, the “Inventory”). Schedule 2.8, as updated
pursuant to Sections 8.5 and 1.3(c) hereof, shall set forth a true, correct and
complete list, in accordance with GAAP, of the Inventory of the Business as of
the date of the Closing Balance Sheet (the “Interim Date”) and as of the
Closing Date, respectively, including a description and valuation thereof. The
Inventory listed on Schedule 2.8 comprises all of the Inventory of the
Business on the Balance Sheet Date and all of the Inventory reflected on the
Current Balance Sheet, and the Inventory listed on Schedule 2.8 as
updated pursuant to Sections 8.5 and 1.3(c) will comprise all of the Inventory
of the Business as of the Interim Date and as of the
Closing Date, respectively, and all of the Inventory reflected on the Closing
Balance Sheet and on the Closing Date Balance Sheet. All of such Inventory was
acquired and has been maintained in the ordinary course of the Business;
consists of a quality, quantity and condition usable, leasable or saleable in
the ordinary course of the Business in accordance with GAAP; is valued at the
lower of cost or market, with allowances for excess and obsolete materials and
materials below standard quality determined in accordance with GAAP and
consistent with the Current Balance Sheet and the BSA Accounts and is not
subject to any material write-down or write-off. None of Seller, BSA or BSG is
under any obligation or has any liability with respect to the return of the
Inventory of the Business in the possession of wholesalers or retailers or any
Inventory previously sold to other customers except in a manner consistent with
past practice.

                           2.9        Fixed Assets. 
Schedule 2.9 attached hereto sets forth a true, correct and complete
list, of all fixed assets of BSA and BSG (the “Fixed Assets”) as of the Balance
Sheet Date, including a description thereof. Schedule 2.9, as updated
pursuant to Sections 8.5 and 1.3(c) hereof, shall set forth a true, correct and
complete list of all Fixed Assets as of the Interim Date and as of the Closing
Date, respectively, including a description thereof. The Fixed Assets listed on
Schedule 2.9 comprise all of the Fixed Assets on the Balance Sheet Date
and all of the Fixed Assets reflected on the Current Balance Sheet, and the Fixed
Assets listed on Schedule 2.9 as updated pursuant to Sections 8.5 and
1.3(c) will comprise all of the Fixed Assets as of the Interim Date and as of
the Closing Date, respectively, and all of the Fixed Assets reflected on the
Closing Balance Sheet and on the Closing Date Balance Sheet, respectively. All
of the Fixed Assets are in adequate operating condition and repair, normal wear
and tear excepted, are usable in the regular and ordinary course of the
Business as conducted by the Seller, BSA and BSG prior to the Closing Date and
conform in all material respects to all applicable statutes, rules, regulations
and ordinances of every governmental authority having jurisdiction over any of
them, and constitute all of the Fixed Assets necessary to operate the Business
as currently conducted by BSA and BSG.

                           2.10      Leases. 
Schedule 2.10 attached hereto sets forth a true, correct and complete
list as of the date hereof of all licenses to use and leases of real property
and equipment, identifying separately each ground lease, to which BSA is a
party (the “Leases”) and any and all capital expenditures made or committed or
agreed to be made under any of the Leases. True, correct and complete copies of
the Leases, and all amendments, modifications and supplemental agreements
thereto, have previously been delivered by the Seller to the Buyer. BSA enjoys
peaceful and undisturbed possession under all such Leases. The Leases are in
full force and effect, are binding and enforceable against BSA and, to the
Seller’s knowledge, each of the other parties thereto, in accordance with their
respective terms and, except as set forth on Schedule 2.10, have not
been modified or amended since the date of delivery to the Buyer. No party to
any Lease has sent written notice to the other claiming that such party is in
default thereunder, which default remains uncured. Except as set forth on Schedule
2.10 attached hereto, BSA is not in breach of or default in the performance
of any covenant, agreement or condition contained in any Lease.  Neither the Seller nor BSA has received
written notice of any violation of any applicable zoning ordinance, building
code, use or occupancy restriction or any condemnation action or proceeding
with respect to any of the premises under the Leases nor is Seller aware of any
basis therefor.

                           2.11      Change in Financial
Condition and Assets. 
Except as set forth on Schedule 2.11 attached hereto, since the Balance
Sheet Date, there has been no material adverse change in any of the Assets or
any assets of BSA or BSG used in the Business or in the condition, financial or
otherwise, of the Business.

             Without limiting the foregoing, except as set forth on Schedule
2.11, since the Balance Sheet Date, (a) neither BSA nor BSG has: (i)
borrowed any amount or incurred or become subject to any liability, except
current liabilities, liabilities under Contracts entered into and borrowings
under banking facilities disclosed in the Schedules hereto; (ii) discharged or
satisfied any Encumbrance or paid any obligation or liability other than
current liabilities shown on the Current Balance Sheet (including regularly
scheduled payments (but not prepayments) of long-term debt) and current
liabilities incurred since the Balance Sheet Date in the ordinary course of the
Business; (iii) failed to pay or discharge when due its liabilities or
obligations; (iv) mortgaged, pledged or subjected to an Encumbrance any of
its assets, tangible or intangible, (v) sold, assigned or transferred any
of its tangible assets except in the ordinary course of the Business consistent
with past practices; (vi) sold, assigned, transferred or granted any license
with respect to any Intangible Property; (vii) made commitments or agreements
for capital expenditures exceeding in the aggregate $25,000; (viii) received
written notice of any actual or threatened labor trouble or strike or union
organizing effort; (ix) granted any severance or termination pay; (x) except as
set forth on Schedule 2.16, increased any compensation or benefits
payable to any of its directors, officers, employees, independent contractors
or consultants; (xi) made any material change in any method of accounting or
accounting practice; (xii) declared, set aside or paid any dividend or made any
distribution on any shares of its capital stock (whether in cash or in kind),
or issued, sold, redeemed, purchased or acquired any shares (including any
options, warrants or other rights with respect thereto) of its capital stock;
(xiii) undertaken any revaluation of any of its assets, including, without limitation,
writing down the value of Inventory or writing off notes or accounts
receivables other than in the ordinary course of Business consistent with past
practices; (xiv) made any material Tax election inconsistent with past
practices or settled or compromised any material Tax liability; (xv) suffered
any event causing a Material Adverse Effect, (xvi) suffered any material damage
or destruction whether or not covered by insurance; (xvii) made any change in
the manner or rate of billing or collections; or (xviii) entered into any
commitment to do any of the foregoing; and (b) the Seller has not taken any of
the foregoing actions or suffered any of the foregoing events, in each case
with respect to the Business, except as otherwise contemplated hereby.

                           2.12      Tax Matters.  (a)  Each of BSA and BSG has filed all Tax
Returns (as hereinafter defined) that it has been required to file (taking into
account all extensions) through and including the date hereof. All such Tax
Returns reflect all liabilities for Taxes for the periods covered by such Tax
Returns. All Taxes owed by BSA and BSG (whether or not shown on any Tax Return)
have been fully and timely paid when due or provided for. Except as disclosed
on Schedule 2.12, none of BSA or BSG is currently the beneficiary of any
extension of time within which to file any Tax Return.  There are no liens on any of the Assets or
the assets of BSA or BSG that arose in connection with any failure (or alleged
failure) to pay any Tax, other than any Tax which is not yet due and payable or
which is being contested in good faith through appropriate proceedings and for
which adequate reserves exist on BSA’s or BSG’s books.  For purposes of this Agreement, “Tax” shall
mean any federal, state, local, municipal or 
foreign income, gross receipts, license, payroll, employment, excise,
severance, stamp, occupation, premium,
windfall profits, gains, environmental (including taxes under Section 59A of
the Internal Revenue Code of 1986, as amended (the “Code”)), customs duties,
capital stock, franchise, profits, withholding, social security (or similar),
unemployment, disability, real property, personal property, sales, use,
transfer, registration, value added, alternative or add-on minimum, estimated,
or other tax of any kind whatsoever, including any interest, penalty or
addition thereto, whether disputed or not, and “Tax Return” shall mean any
return, declaration, report, claim for refund or information return or
statement relating to Taxes, including any schedule or attachment thereto and
any amendment thereof.

                                        (b)        Each of BSA and BSG has withheld and paid all Taxes required
to have been withheld and paid in connection with amounts paid by it or owing
by it to any employee, independent contractor, creditor, stockholder or other
third party.

                                        (c)         Except as set forth on Schedule 2.12, none of BSA,
Seller or BSG has received written notice from any authority of such
authority’s intent to assess any additional Taxes against BSA or BSG with
respect to any period for which Tax Returns have been filed nor is Seller aware
of any basis therefor.  Schedule 2.12
indicates those Tax Returns with respect to BSA and BSG for taxable periods
ended on or after December 31, 1997 that have been audited by a taxing
authority, and that currently are the subject of audit by a taxing authority.
The Seller has made available to the Buyer correct and complete copies of all
BSA’s and BSG’s income Tax Returns, examination reports, and statements of
deficiencies assessed against or agreed to by BSA or BSG since January 1,
1998.  Neither BSA nor BSG has waived
any statute of limitations in respect of the assessment and collection of Taxes
or agreed to any extension of time with respect to a Tax assessment or
deficiency.

                                        (d)        None of the Assumed Liabilities is an obligation to make a
payment that will not be deductible under Section 280G of the Code.  None of the Seller, BSA or BSG has been a
United States real property holding corporation within the meaning of Section 897(c)(2)
of the Code during the applicable period specified in Section 897(c)(1)(A)(ii)
of the Code. Neither BSA nor BSG is a party to any Tax allocation or sharing
agreement. Neither BSA nor BSG (i) has been a member of an affiliated group
(within the meaning of Section 1504 of the Code) filing a consolidated U.S.
federal income Tax Return (other than a group of which the Seller or BioSepra
Inc. was the common parent), and (ii) is liable for the Taxes of any other
person under Treas. Reg. § 1.1502-6 (or any similar provision of state, local
or foreign law), as a transferee or successor, by contract or otherwise.

                                        (e)         BSA does not benefit from any advantageous tax regime or
social security regime granted by law or by a specific ruling from any French
governmental or local authority that may be challenged, either in part or in
whole, as a result of the sale of the BSA Shares.

                                        (f)         All material elections and consents with respect to any Tax
(or the computation thereof) affecting BSA or BSG as of the date hereof are
indicated on the Tax Returns if and to the extent required to be indicated
thereon or are set forth on Schedule 2.12.  After the date hereof, no election or consent with any respect to
any Tax (or computation thereof) affecting BSA or BSG will be made without
written consent of the Buyer (which consent shall not be unreasonably withheld
or delayed).

                                        (g)        The unpaid taxes of BSA and BSG have not (i) exceeded, as of
the Balance Sheet Date, the reserve for Tax liability (rather than in any
reserve for deferred Taxes established to reflect timing difference between
book and Tax income) set forth on the face of the Current Balance Sheet (rather
than in any notes thereto), or (ii) exceeded that reserve as adjusted for the
passage of time through the Closing Date in accordance with the past custom and
practice of BSA and BSG in filing its Tax Returns.

                                        (h)        BSA is not party to any “acte
anormal de gestion”, being defined as a transaction or arrangement
under which it may be required to pay for any asset or any services or
facilities an amount which is in excess of the market value of such asset,
services or facilities, or will receive any payment for an asset, services or
facilities that it had supplied or provided, or is liable to supply or provide,
which is less than the market value of such asset, services or facilities.

                           2.13      Accounts Receivable. 
Schedule 2.13 attached hereto sets forth a true, correct and complete
list of all accounts, accounts receivable, notes and notes receivable of BSA
(collectively the “Accounts Receivable”), including an aging thereof, as of the
Balance Sheet Date. Schedule 2.13, as updated pursuant to Sections 8.5
and 1.3(c) hereof, shall set forth a true, correct and complete list of the
Accounts Receivable of BSA as of the Interim Date and as of the Closing Date, respectively,
including an aging thereof. The Accounts Receivable listed on Schedule 2.13
comprise all of the Accounts Receivable of BSA as of the Balance Sheet Date and
all of the Accounts Receivable of BSA reflected on the Current Balance Sheet,
and the Accounts Receivable listed on Schedule 2.13 as updated pursuant
to Sections 8.5 (other than Intercompany Accounts) and 1.3(c) will comprise all
of the Accounts Receivable of BSA as of the Interim Date and as of the Closing
Date, respectively, and all of the Accounts Receivable of BSA reflected on the
Closing Balance Sheet (other than Intercompany Accounts) and on the Closing
Date Balance Sheet, respectively. All of the Accounts Receivable of BSA are
valid and genuine and have arisen solely out of bona fide sales and deliveries
of goods, performance of services and other business transactions. The Seller,
BSA and BSG have fully performed all obligations with respect thereto which
they were obligated to perform prior to the date of the Current Balance Sheet,
the Closing Balance Sheet or the Closing Date Balance Sheet, as applicable.

                           2.14      Contracts and
Commitments.

                                        (a)         Schedule 2.14 attached hereto contains a true,
complete and correct list of the following contracts, arrangements, commitments
and agreements, whether written or oral (collectively, “Contracts”) (other than
a Contract which is an Excluded Asset), (x) by which any of the Assets are
bound or affected, (y) to which Seller is a party or by which it is bound
solely in connection with the Business or any of the Assets and (z) to which
BSA or BSG is a party or by which any of their assets or properties are bound
or affected:

                                                     (i)          all loan agreements, indentures,
mortgages and guaranties;

                                                     (ii)         all Contracts which involve payments or
receipts of more than $20,000 under which full performance (including payment)
has not been rendered by all parties thereto;

                                                     (iii)        all agency, distributor, sales
representative and similar agreements;

                                                     (iv)       all Contracts with any stockholder,
director, officer or Affiliate of the Seller, BSA or BSG;

                                                     (v)        all leases, whether operating, capital
or otherwise, which involve payments of more than $20,000 per year;

                                                     (vi)       any license to or for any Intangible
Property (other than customary end user license agreements to readily available
software);

                                                     (vii)      Contracts containing any covenant not to
compete obligating Seller, BSA or BSG with respect to the Business; or

                                                     (viii)     any other material Contract not included in
subparagraphs (i) – (vii) above.

                                        (b)        Except as set forth on Schedule 2.14 attached hereto:

                                                     (i)          each Contract is in full force and
effect and is a valid and binding agreement of the Seller, BSA or BSG, as the
case may be, enforceable against the Seller, BSA or BSG, as the case may be, in
accordance with its terms and the Seller does not have any knowledge that any
Contract is not a valid binding agreement of the other parties thereto;

                                                     (ii)         none of the Seller, BSA or BSG is in
breach of or default under any Contract and to the knowledge of Seller no event
has occurred which with the passage of time or giving of notice or both would
constitute a default, result in a loss of rights or an acceleration of an
obligation or result in the creation of any Encumbrance thereunder or pursuant
thereto; and

                                                     (iii)        to the knowledge of the Seller, there is
no existing breach or default by any other party to any Contract, no event has
occurred which with the passage of time or giving of notice or both would
constitute a default, result in a loss of rights or an acceleration of an
obligation or result in the creation of any Encumbrance thereunder or pursuant
thereto; and

                                        (c)         Except as set forth on Schedule 2.3 or Schedule
2.14, the continuation, validity, enforceability and effectiveness of each
Contract will not be affected by the consummation of the transactions
contemplated by this Agreement.

                                        (d)        True, correct and complete copies of all written Contracts
and true, correct and complete summaries of all oral Contracts have previously
been made available by the Seller to the Buyer.

                                        (e)         No party to any Contract has repudiated any provision
thereof and communicated such repudiation to the Seller, and there are no
negotiations pending or in progress to revise any material terms of any
Contract.

                                        (f)         Except for Contracts set forth on Schedule 2.14, (i)
no Contracts which are purchase contracts continue for a period of more than 12
months or are for quantities or amounts in excess of the normal, ordinary,
usual and current requirements of the Business and (ii) no Contracts obligate
the Seller, BSA or BSG to sell products or to render services pursuant to terms
and conditions the Seller, BSA or BSG cannot reasonably expect to satisfy or
fulfill in their entirety.

                           2.15      Compliance with
Agreements and Laws. 
The Seller, BSA and BSG have all material licenses, permits, certificates,
authorizations and approvals including environmental, health and safety and
employee health and safety permits, from foreign, federal, state and local
authorities necessary to conduct the Business as currently conducted
(collectively, the “Permits”), all of which Permits are set forth on Schedule
2.15. All of the Permits identified in Schedule 2.15 are in full
force and effect, and no party thereto is in default under any of such Permits
and no event has occurred and no condition exists which with the giving of
notice, the passage of time or both, would constitute a default thereunder. No
action or claim is pending or, to Seller’s knowledge, threatened, to revoke or
terminate any Permit identified in Schedule 2.15. None of the Seller
(solely with respect to the Business), BSA or BSG is in material violation of
any law, rule, regulation, ordinance or court or administrative order
(including, without limitation, those relating to building, zoning,
environmental, disposal of hazardous substances, land use, health and safety
and employee health and safety matters). Except as set forth on Schedule
2.15 attached hereto, none of the Seller, BSA or BSG has received any
written notice or communication from any foreign, federal, state or local
governmental or regulatory authority or otherwise of any such violation
relating to the Business or the Assets, and to Seller’s knowledge, no such
notice or communication is threatened. BSA is ISO 9001 certified.  The Seller believes that its production and
documentation procedures are consistent with Good Manufacturing Practices as
prescribed by the United States Food and Drug Administration as applicable to a
supplier to the pharmaceutical industry.

                           2.16      Employee Relations and
Benefit Plans.

                                        (a)         Schedule 2.16(a) attached hereto sets forth a true,
correct and complete list of the names, the rate of compensation (and the
portions thereof attributable to salary and bonuses, respectively) and location
of (i) all current officers, employees and independent contractors of and
consultants to BSA (the “BSA Employees”) and (ii) of all current officers,
employees and independent contractors of and consultants to Seller who devote a
material portion of their time to the Business and to whom Buyer shall make an
offer of employment in accordance with Section 7 (the “Affected Employees”).
BSG does not employ any employees, independent contractors or consultants.

                                        (b)        Except as set forth on Schedule 2.16(b) hereto:

                                                     (i)          BSA is in compliance in all material
respects with all foreign, municipal and French laws respecting employment,
employee benefit plans and employment practices, terms and conditions of
employment, and wages and hours, and is not engaged in any unfair labor
practice, and there are no arrears in the payment of wages or social security
taxes.

                                                     (ii)         None of the BSA Employees are currently
represented by any labor union.

                                                     (iii)        There is no unfair labor practice
complaint against BSA pending before the French Labour Inspectorate or any
federal, state, local or foreign agency.

                                                     (iv)       There is no pending labor strike or other
labor trouble or grievance affecting the BSA Employees (including, without
limitation, any organizational drive targeted directly or indirectly at the BSA
Employees).

                                                     (v)        Neither the Seller nor, except as may be
required by French law, BSA, has any liability for salary, commissions,
bonuses, vacation, sick leave, maternity leave or other compensation, fringe
benefits or termination or severance benefits due to the BSA Employees except
as will be set forth or reserved for on the Closing Balance Sheet and the
Closing Date Balance Sheet.

                                                     (vi)       No employment contract of any of the BSA
Employees contains provisions for compensation in the event of redundancy or
retirement which are more favorable than those under the law governing the said
contract or the applicable collective bargaining agreement.

                                                     (vii)      Neither BSA nor the Seller has given any
written undertakings to any of the BSA Employees, including, but without
limitation, to increase salaries, pay any bonus, grant any profit share or
supplementary pension or other individual advantage, which has not been duly
provided for in the BSA Accounts.

                                                     (viii)     No employment contract of any BSA Employee
provides for payment of damages, interest or compensation, which exceeds that
stipulated by applicable law or by the applicable collective bargaining
agreement.

                                                     (ix)        No BSA Employee with the status of “cadre” (executive) has given notice to
resign, or has received a redundancy notice. No sums are owing to former BSA
Employees as a result of any redundancy, dismissal or resignation that are not
reflected in the BSA Accounts. No BSA Employee having received a redundancy notice
has, on the date hereof, requested preferential treatment for re-employment.

                                                     (x)         Except as provided for by law or in any
applicable collective bargaining agreement, there are no schemes, agreements or
arrangements in existence which grant special benefits to any BSA Employees,
including, in particular, with respect to supplementary pension and retirement
rights. As such, there are no superannuation, pension, life assurance, death
benefit, sickness or accident benefit schemes or arrangements in existence
which grant to any BSA Employees supplementary benefits other than those
required by law.

                                                     (xi)        With respect to the BSA Employees, BSA
and the Seller have complied in all material respects with all applicable
French labor, social security, health and safety at work regulations,
including, without limitation, in relation to redundancy, employees’
representation and social security contributions. In particular, the elections
of personnel representatives have been duly held within the correct time limits
and any necessary consultation with personnel representatives, works councils
and trade union representatives has been carried out in accordance with all
applicable laws and regulations.

                                                     (xii)       There are no current disputes between BSA
or the Seller and any trade union or similar organization with respect to the
BSA Employees.

                                                     (xiii)      Neither BSA nor the Seller is in breach of
its statutory obligations concerning the health and safety at work of the BSA
Employees, nor has it received written notice of any claim against it by any
employee or third party relating to an accident.

                                                     (xiv)      Except as provided for by law or in any
applicable collective bargaining agreement, none of the BSA Employees are
subject to any obligation under any subscription program, share-option or
profit-sharing schemes reserved to its employees.

                                                     (xv)       The only collective bargaining agreement
applicable to BSA Employees is disclosed in Schedule 2.16(b).

                                                     (xvi)      Each of the BSA Employees is employed
exclusively in the business of BSA and no BSA Employee is currently on
secondment (“detache”) to the
Seller, any affiliate of the Seller or any third party.

                           2.17      Customers. 
Schedule 2.17 attached hereto sets forth a true, correct and complete
list of the names and addresses of all customers of the Seller, of BSA or BSG
which individually accounted for more than 5% of the total sales of the
Business in the fiscal year ended December 31, 2000.  The Seller has not received written notice from any of the
customers listed on Schedule 2.17 that such customer intends to cease
purchasing from the Seller, BSA or BSG or to decrease the amount of purchases
from the Seller, BSA or BSG.

                           2.18      Suppliers. 
Schedule 2.18 attached hereto sets forth a true, correct and complete
list of the names and addresses of all suppliers of the Seller, BSA and BSG
which individually accounted for more than 5% of the total purchases of the
Business for the fiscal year ended December 31, 2000.  The Seller has not received written notice from any of the
suppliers listed on Schedule 2.18 that such supplier intends to cease
selling to the Seller, BSA or BSG or to alter the amount of such sales to the
Seller, BSA or BSG.

                           2.19      Trade Names and Other
Intangible Property.  (a)  Schedule 2.19(a) attached hereto sets
forth a true, correct and complete list of all trademarks, patents, patent
applications, invention records, lab notebooks, procedures (“SOPs”) and
research and development activity reports of the Seller which relate primarily
to or are used or held for use in connection with the Business (other than an
Excluded Asset as set forth in Schedule 1.1(b)(i)) and all trademarks,
patents, patent applications, invention records, lab notebooks, SOPs and
research and development activity reports of BSA. True, correct and complete
copies of all licenses and other agreements relating to the Intangible Property
have been previously made available by the Seller to the Buyer and are listed
on Schedule 2.14.  All such
licenses and agreements are in full force and effect and neither the Seller nor
BSA or, to the Seller’s knowledge, any of the other parties to such licenses or
agreements is in breach of any provision of,
or in default under any of the terms of, such licenses or agreements and, to
the Seller’s knowledge, no condition exists which, with the passage of time,
the giving of notice, or both, would result in a breach or default.  Assuming that all consents and approvals set
forth on Schedule 2.3 have been obtained, the consummation of the
transactions contemplated by this Agreement neither constitutes a breach of nor
causes a termination of any such license or agreement.

                                        (b)        Schedule 2.19(b) attached hereto sets forth a true,
correct and complete list, and where appropriate, a description, of all
Intangible Property set forth in Schedule 2.19(a) to which neither
Seller nor BSA’s rights are exclusive. Except as otherwise disclosed in Schedule
2.19(b) attached hereto, the Seller or BSA exclusively owns or has the
exclusive right to use all Intangible Property listed on Schedule 2.19(a).  Seller has not wrongfully utilized or
misappropriated the trade secrets of any third party. The Intangible Property
set forth in Schedule 2.19(a) is sufficient to enable the Seller and BSA
to conduct the Business as presently conducted by the Seller and BSA.

                                        (c)         To Seller’s knowledge, no person or entity is infringing
upon, is in violation of, or is misappropriating or misusing any of the
Intangible Property.  Except as set
forth in Schedule 2.19(b), subsequent to the Closing, no other party,
including but not limited to, any current or former director, officer,
stockholder, employee or consultant of the Seller or BSA will own, have an
interest in or have the right to use any Intangible Property which is being
utilized in the Business (other than an Excluded Asset as set forth in Schedule
1.1(b)(i). Except as disclosed in Schedule 2.19(b), there is no
pending or, to the Seller’s knowledge, threatened claim or litigation against
the Seller or BSA contesting its right to use any Intangible Property nor to
Seller’s knowledge is there any basis therefor. Except as disclosed in Schedule
2.19(b), there is no pending or, to the Seller’s knowledge, threatened
claim or litigation against the Seller or BSA asserting the misappropriation or
misuse of any trade secret or any confidential or proprietary invention,
discovery, process, formula, know-how, technology or information of another nor
to Seller’s knowledge is there any basis therefor.  Except as disclosed in Schedule 2.19(b), there is no
pending or, to the Seller’s knowledge, threatened claim or litigation against
the Seller or BSA asserting that the Seller or BSA has violated or infringed
any patent nor to Seller’s knowledge is there any basis therefor. Except as
disclosed in Schedule 2.19(b), there is no pending or, to the Seller’s
knowledge, threatened claim or litigation against the Seller or BSA asserting
that the Seller or BSA has violated or infringed any trademark, trade name,
copyright or other property right of another nor to Seller’s knowledge is there
any basis therefor.  This Agreement and
the consummation of the transactions contemplated hereby will not affect the
continuation, validity and effectiveness of any right in the Intangible
Property being transferred to Buyer or owned by BSA.  Since May 17, 1999, the Seller (solely with respect to the
Business) and BSA have not conducted business under any corporate, trade or
fictitious name other than the names listed on Schedule 2.19(c) hereto.

                           2.20      Real Estate. 
Neither BSA nor BSG owns any real property, except for fixtures or other
installations on the premises leased by BSA or BSG which may be considered real
property.

                           2.21      Powers of Attorney. 
Except as set forth on Schedule 2.21 attached hereto, none of BSA or BSG
has any general or special powers of attorney outstanding (whether as grantor
or grantee thereof).

                           2.22      Brokers. 
The Seller represents and warrants that none of the Seller, BSA or BSG has
engaged any broker or finder or incurred any liability for brokerage fees,
commissions or finder’s fees in connection with the transactions contemplated
by this Agreement.

                           2.23      No Illegal or Improper
Transactions. 
None of the Seller (solely with respect to the Business), BSA or BSG has
offered, paid or agreed to pay to any person or entity (including any
governmental official) or solicited, received or agreed to receive from any
person or entity, directly or indirectly, any money or thing of value for the
purpose or with the intent of (a) obtaining or maintaining business for the Seller,
BSA or BSG, (b) facilitating the purchase or sale of any product or service, or
(c) avoiding the imposition of any fine or penalty, in any such case in any
manner which is in violation of any applicable ordinance, regulation or law.

                           2.24      Environmental Matters.  (a)     The Seller (solely with respect to the
Business), BSA and BSG have complied in all material respects with all
Environmental Laws. There is no pending or, to the Seller’s knowledge,
threatened civil or criminal litigation, written notice of violation, formal
administrative proceeding or investigation, inquiry or information request by
any person or entity relating to any Environmental Law involving the Seller
(solely with respect to the Business), BSA and BSG nor to Seller’s knowledge is
there any basis therefor. For purposes of this Agreement, “Environmental Law”
means any federal, state, local or foreign law, statute, code, rule,
regulation, ordinance, order or consent
decree relating to
pollution, hazardous substances or waste, natural resources, the environment or
occupational health and safety, including, without limitation, the Resource
Conservation and Recovery Act (42 U.S.C. §6901, et seq., as amended), the
Comprehensive Environmental Response, Compensation and Liability Act (42 U.S.C.
§9601, et seq., as amended), the Toxic Substance Act (15 U.S.C. §2601 et seq.,
as amended), the Clean Water Act (33 U.S.C. §466, et seq., as amended), the
Clean Air Act (42 U.S.C. §7401, et seq., as amended) and federal and state
environmental cleanup programs.

                                        (b)        BSA has obtained all requisite environmental permits relating
to the Business and such permits are in full force and effect.  The environmental permits do not materially
limit or affect the processes, methods, capacity or operating hours of the
persons carrying on the Business as currently carried on.  No material capital expenditure is currently
required by BSA in relation to environmental matters relating to the Business
in order to comply with, extend, renew or obtain any environmental permit or
comply with Environmental Laws.  To the
Seller’s knowledge,  transfer of the BSA
Shares and the transactions contemplated hereunder will not result in (i) the
variation, limitation or revocation of any environmental permit or (ii) any
environmental permit not being extended, renewed or granted.  To the Seller’s knowledge, none of the real
properties on which BSA carries on the Business is contaminated, and no
pollution or contamination has migrated to or otherwise affected any other
property used in the Business.  All
environmental audits and other assessments, reviews and reports relating solely
to the Business in possession or control of the Seller or BSA have been
disclosed to the Buyer.

                           2.25      Product Warranties;
Liabilities.

                                        (a)         Except as set forth in Schedule 2.7,
none of Seller, BSA or BSG has any outstanding material disputes concerning
products or services of the Business with any customers.  None of Seller, BSA or BSG has any
outstanding material disputes concerning goods or services provided by any
supplier.

                                        (b)        The Seller has furnished the Buyer with the terms of sale
containing the warranties or guarantees of products and services that are in
effect in the conduct of the Business. 
There are no pending or, to knowledge of the Seller, threatened claims
against the Seller, BSA or BSG under any warranty or guaranty.

                           2.26      Bankruptcy. 
BSAis not the subject of any
procedure for its judicial receivership (“redressement
judiciaire”) or any similar or equivalent procedure or liquidation (“liquidation judiciaire”), and no
judicial administrator (“administrateur
judiciaire”) or liquidator has been appointed in respect of it.
Neither BSA nor the Seller has commenced negotiations with one or more of BSA’s
creditors with a view to the general readjustment or rescheduling of its
indebtedness, nor has it made a general assignment for the benefit of its
creditors. No receiver or arbitrator (“conciliateur”)
has been appointed in the context of amicable receivership (“reglement amiable” or “mandataire ad hoc”) proceedings in
respect of BSA.

                           2.27      Insurance. 
Schedule 2.27 sets forth all insurance policies maintained by BSA or BSG
(including any self-insurance arrangements) and the type and amounts of
coverage thereunder. All of such policies are in full force and effect and will
be maintained until the Closing, none of BSA or BSG is delinquent with respect
to any premium payments thereon, no written notice of cancellation has been
received, and there is no existing default thereunder,
and such insurance, together with the insurance maintained by Seller with
respect to the Business, is of the type and in the amount customary for
businesses such as the Business.

                           2.28      Books and Records.  The general
ledgers and books of account of BSA and BSG, all federal, state, local and
foreign income, franchise, property and other tax returns filed by BSA or BSG
and all other books and records of BSA and BSG are complete and correct in all
material respects and have been maintained in accordance with good business practice
and in accordance with all applicable procedures required by laws and
regulations.

             3.          Representations of the
Buyer.

             The Buyer represents and warrants to the Seller as
follows, except as set forth on the respective Schedules attached hereto:

                           3.1        Organization and
Authority. 
The Buyer is a corporation duly organized, validly existing and in good
standing under the laws of the State of Delaware, and has all requisite power
and authority (corporate and other) to own its properties and to carry on its
business as now being conducted. The Buyer has full power to execute and
deliver this Agreement and the other agreements contemplated hereby and to
consummate the transactions contemplated hereby and thereby.

                           3.2        Authorization. 
The execution and delivery of this Agreement by the Buyer, and the agreements
provided for herein, and the consummation by the Buyer of all transactions
contemplated hereby and thereby, have been duly authorized by all requisite
corporate action.  This Agreement and
all such other agreements and written obligations entered into and undertaken
in connection with the transactions contemplated hereby to which the Buyer is a party constitute or will, when executed
and delivered, constitute the valid and legally binding obligations of the
Buyer, enforceable against the Buyer in accordance with their respective terms.
This Agreement has been, and each other agreement contemplated hereby to which
the Buyer is a party will be, duly executed and delivered by the Buyer.

                           3.3        No Conflicts; Consents.  The execution
and delivery of this Agreement do not, and the consummation of the transactions
contemplated hereby and compliance with the provisions hereof will not, result
in any violation of, constitute a default (with or without notice or lapse of
time, or both) under, or require the approval or consent of its shareholders or
any other person or entity under, (i) the Certificate of Incorporation or
By-laws of Buyer, (ii) any judgment, order, decree, statute, law, rule or
regulation applicable to Buyer or its properties or assets, or (iii) any
material agreement or instrument, permit, concession, franchise or license to
which Buyer is a party or by which Buyer is bound.  The execution and delivery of this Agreement by Buyer, and the
consummation by the Buyer of the transactions contemplated by this Agreement
will not require any action by or in respect of, or consent or approval of, or
filing with, any Governmental Entity, except as required except for such
approvals or filings the failure of which to obtain will not, individually or
in the aggregate, have a material adverse effect on Buyer’s ability to perform
its obligations hereunder or to consummate the transactions contemplated
hereby.

                           3.4        Brokers. 
The Buyer represents and warrants that it has not engaged any broker or finder
or incurred any liability for brokerage fees, commissions or finder’s fees in
connection with the transactions contemplated by this Agreement.

             4.          Access to Information;
Confidentiality; Public Announcements.

                           4.1        Access to Management,
Properties and Records. 
From the date of this Agreement until the Closing Date, the Seller shall afford
the officers, attorneys, accountants and other authorized representatives of
the Buyer access upon reasonable notice and during normal business hours to all
management personnel, offices, properties, books and records (including without
limitation Tax reports, returns and related materials) of BSA and of the Seller
relating solely to the Business, so that the Buyer may have full opportunity to
make such investigation as it shall desire to make of the management, business,
properties and affairs of BSA and of the Seller relating solely to the
Business.  The Seller shall furnish to
the Buyer such financial and operating data and other information as to the
Assets and the Business as the Buyer shall reasonably request.

                           4.2        Confidentiality. 
All information which shall have been furnished by the Seller to the Buyer in
connection with the transactions contemplated hereby or as provided pursuant to
this Section 4 shall be subject to the terms of that confidentiality agreement
between the Buyer and the Seller dated May 11, 2001 (the “Confidentiality
Agreement”).  The Confidentiality
Agreement shall continue in full force and effect until the Closing, at which
time the obligations of the Buyer under the Confidentiality Agreement shall
terminate but only in
respect of that information furnished
pursuant to this Agreement or the Confidentiality Agreement relating
exclusively to the Assets and to the Business.

                           4.3        Public Announcements. 
The parties agree that prior to the Closing Date, except as otherwise required
by law, any and all public announcements concerning this Agreement and the
purchase of the Business by the Buyer shall be subject to the approval of both
parties, which approval shall not be unreasonably withheld.

             In the event that either party is required to issue a
press release or make a public announcement or filing by law, it will notify
the other party prior to the release of any such public announcement or filing
and will provide to the other a copy of any such public announcement or
filing.  Buyer acknowledges that Seller
intends to make a public announcement upon the execution of this Agreement.

             5.          Pre-Closing Covenants of
the Seller.

             The Seller covenants that from and after the date hereof
and until the Closing Date:

                           5.1        Conduct of Business. 
The Seller, BSA and BSG shall carry on the Business in the ordinary course and
shall not make or institute any material changes in methods of manufacture,
purchase, sale, shipment or delivery, lease, management, accounting,
computation of Taxes or operation, except as agreed to in writing by the
Buyer.  Each of the Seller, BSA and BSG
shall (a) use commercially reasonable efforts to maintain, preserve and protect
the Assets and the Business, and (b) comply in all material respects with all
laws, ordinances, rules, regulations and orders applicable to the Business.

                           5.2        Absence of Material
Changes. 
Without the prior written consent of the Buyer, the Seller shall not, solely
with respect to the Business, and BSA shall not, in any case:

                                        (a)         Acquire by merging or consolidating with, or by purchasing a
substantial portion of the assets of, or by any other manner, any business of
any corporation, partnership, joint venture, association, or other business
organization or division thereof;

                                        (b)        Make any election or give any consent under the Code or the
Tax statutes of any state or other jurisdiction or make any termination,
revocation or cancellation of any such election or any consent or compromise or
settle any claim for past or present Tax due;

                                        (c)         Fail to operate the Business or to maintain its books,
accounts and records with respect to the Business in the ordinary course of
business consistent with past practices;

                                        (d)        Knowingly cause or permit to occur any of the events or
occurrences described in Section 2.11; or

                                        (e)         Amend its or other governing documents;

                                        (f)         Authorize for issuance, issue, sell, pledge, or deliver
(whether through the issuance or granting of additional options, warrants,
commitments, subscriptions, rights to purchase, or otherwise) any stock of any
class or any securities exercisable for the purchase of, or convertible into,
shares of stock of any class (other than the issuance of (i) shares of its
capital stock or options to purchase its capital stock pursuant to an existing
option plan in the ordinary course of business, and (ii) shares of its capital
stock pursuant to the exercise of rights outstanding on the date of this
Agreement);

                                        (g)        Split, combine, or reclassify any shares of its capital stock
(whether by merger, consolidation, reorganization or otherwise), declare, set
aside, or pay any dividend or other distribution (whether in cash, stock, or property
or any combination thereof) in respect of its capital stock, or redeem or
otherwise acquire any shares of its capital stock or its other securities; or
amend or alter any material term of any of its outstanding securities;

                                        (h)        Other than trade payables incurred and use of existing credit
facilities in the ordinary course of business and consistent with past practice
and other than intercompany indebtedness, create, incur or assume any
indebtedness for borrowed money, or assume, guarantee, endorse, or otherwise
agree to become liable or responsible for the obligations of any other person,
or make any loans, advances or capital contributions to (other than reasonable
travel advances for Business purposes), or investments in, any other person; or
create, incur or assume any Encumbrance on any Asset;

                                        (i)          Except as set forth in Schedule 5.2, (i) increase in
any manner the compensation of any of its directors, officers, employees, or
consultants, or accelerate the payment of any such compensation, except
anniversary date salary increases for employees in the ordinary course of
business and in a manner consistent with past practices or as required by
existing contractual commitments or applicable law; (ii) pay or accelerate or
otherwise modify the payment, vesting exercisability, or other feature or
requirement of any pension, retirement allowance, severance, change of control,
stock option, or other employee benefit to any such director, officer, employee
or consultant or (iii) except as required by existing contractual commitments
or applicable laws, commit itself to any additional or increase pension,
profit-sharing, bonus, incentive, deferred compensation, group insurance,
severance, change of control, retirement or other benefit, plan, agreement, or arrangement,
or to any employment or consulting agreement, with or for the benefit of any
person, or amend any such plans or any of such agreements in existence on the
date hereof (except any amendment required by law or that would not materially
increase benefits under the relevant plan);

                                        (j)          Except in the ordinary course of business and consistent
with past practice or pursuant to contractual obligations existing on the date
hereof, sell, transfer, mortgage, or otherwise dispose of or encumber any Assets;

                                        (k)         Except as set forth in Schedule 2.11 with
respect to the Zirconia suite, make or agree to make any capital expenditure or
expenditures, except for capital expenditures of $ 10,000 or less individually
and of $50,000 or less in the aggregate;

                                        (l)          Except in the ordinary course of business, enter into or
terminate, or amend, extend, renew or otherwise modify in any material respect
(including, but not limited to, by default or by failure to act) any joint
ventures or any other agreements, protocols or work plans pursuant to
agreements with third parties, commitments, or contracts (except agreements,
commitments, or contracts expressly provided for or contemplated by this
Agreement);

                                        (a)         Enter into any contract, plan, agreement, understanding, arrangement
or obligation that restricts its, or after the consummation of the transactions
contemplated hereunder would restrict BSA’s, BSG’s or the Buyer’s ability to
conduct any line of business;

                                        (m)        Change in any material respect its
general credit policy as to sales of inventories or collection of receivables
or its inventory consignment practices;

                                        (n)        Remove or permit to be removed from any building, facility,
or real property any material machinery, equipment, fixture, vehicle, or other
personal property or parts thereof, except in the ordinary course of business
consistent with past practice, other than any Excluded Asset;

                                        (o)        Alter or revise its accounting principles, procedures,
methods, or practices in any material respect, except as required by applicable
law or regulation or by a change in GAAP or it’s equivalent in France or
Germany and concurred with by Seller’s, BSA’s or BSG’s independent public
accountants;

                                        (p)        Institute, settle, or compromise any claims, action, suit, or
proceeding pending or threatened by or against it involving amounts in excess
of $50,000, at law or in equity or before any government body or any
nongovernmental self-regulatory agency;

                                        (q)        Knowingly take any action, or knowingly fail to take any
action that would render any representation, warranty, covenant, or agreement
of Seller in this Agreement inaccurate or breached such that the conditions in
Section 8.1 will not be satisfied as of the Closing Date; or

                                        (r)         Agree or consent, whether in writing or otherwise, to do any
of the foregoing.

                           5.3        Taxes. 
BSA or BSG shall, on a timely basis, prepare in compliance with all applicable
regulations and file all Tax Returns for and pay any and all Taxes which shall
become due on or prior to the Closing Date, provided that the Seller shall
furnish the Buyer with a copy of any Tax Return of BSA or BSG at least 10 days
prior to its filing date.

                           5.4        Communication with
Customers and Suppliers. 
The Seller, BSA and the Buyer will cooperate in communicating with suppliers
and customers of the Business regarding the transfer of the Assets to the
Buyer.

                           5.5        Compliance with Laws.  Except as set
forth in Schedule 2.15, the Seller, BSA or BSG will comply with all
laws and regulations which are applicable to either Seller’s ownership of the
Assets or to the conduct of the Business and will perform and comply with all
Contracts, commitments and obligations by which each are bound and which, in
the case of the Seller, relate solely to the Business.

                           5.6        Continuing Obligation to
Inform.  From time to
time prior to the Closing, the Seller will deliver or cause to be delivered to
the Buyer supplemental information concerning events subsequent to the date
hereof which would render any statement, representation or warranty in this Agreement
or any information contained in any Schedule inaccurate or incomplete in any
material respect at any time after the date hereof until the Closing Date.

             6.          Reasonable Best Efforts
to Obtain Satisfaction of Conditions.

             The Seller and the Buyer covenant and agree to use their
reasonable best efforts and the Seller covenants to cause BSA to use its
reasonable best efforts to obtain the satisfaction of the conditions to closing
specified in this Agreement. In particular, the Seller shall, and shall cause
BSA to, seek and use reasonable best efforts to obtain all consents and
approvals set forth on Schedule 2.3.

             7.          Employment Matters.

                                        (a)         Prior to the Closing, but subject to the consummation of the
transactions contemplated by this Agreement, Buyer shall offer employment to
each of the Affected Employees, which employment shall become effective as of
the day after the Closing Date.

                                        (b)        The initial salary and wage compensation payable to each
Affected Employee by Buyer shall be, in the aggregate, substantially equivalent
to that provided to such individual by Seller immediately prior to the Closing.

                                        (c)         Buyer shall provide the Affected Employees with employee
benefits that are, in the aggregate, comparable to those benefits provided to
similarly situated employees of Buyer (other than any such benefits consisting
of or based on any equity securities). 
Buyer shall provide credit for eligibility and vesting purposes for all
Affected Employees’ period of service with Seller or its predecessors for purposes
of any of Buyer’s employee benefit plans or programs provided to Affected
Employees, including vacation and compensatory and fringe benefit plans and
programs, but solely to the extent such prior service credit does not result in
the duplication of benefits.

                                        (d)        Any individual who is employed under a written employment
agreement that is being assumed by Buyer pursuant to Section 1.1(a)(iii) shall
be deemed to be an Affected Employee for all purposes of this Agreement.

                                        (e)         Buyer agrees to pay and be obligated for any severance
obligation or liability of Seller arising from or related to any Affected
Employee who does not accept Buyer’s offer of employment.

                                        (f)         The representations, warranties, covenants and agreements
contained in this Section 7 are for the sole benefit of the parties hereto, and
the Affected Employees are not intended to be and shall not be construed as
beneficiaries hereof.

             8.          Conditions to
Obligations of the Buyer.

             The obligations of the Buyer under this Agreement are
subject to the fulfillment, on or before the Closing Date, of the following
conditions precedent, each of which may be waived in writing in the sole
discretion of the Buyer:

                           8.1        Continued Truth of
Representations and Warranties of the Seller; Compliance with Covenants and
Obligations. 
The
representations and warranties of the Seller
contained in this Agreement (including the Schedules hereto) shall be true  and correct in all respects on and as of the
Closing Date as though such representations and warranties were made on and as
of such date, except for any representation or warranty which speaks as of a
specified date, in which case such representation or warranty shall be true in
all respects as if made on such specified date, and except in any case for any
inaccuracies of representations and warranties that individually and in the
aggregate have not had, or would not have a Material Adverse Effect. The Seller
and BSA shall have performed and complied in all material respects with all
covenants, obligations, and agreements required by this Agreement to be
performed or complied with by them prior to or at the Closing Date.

                           8.2        Corporate Proceedings. 
All corporate and other proceedings required to be taken on the part of the
Seller to authorize or carry out this Agreement and to convey, assign, transfer
and deliver the Assets shall have been taken and shall be reasonably
satisfactory to Buyer and its counsel.

                           8.3        Consents of Third
Parties. 
The Seller shall have received all requisite consents and approvals and shall
have made all requisite notifications or filings set forth on Schedule 2.3
attached hereto, and copies thereof shall be delivered to the Buyer at or prior
to the Closing.

                           8.4        Adverse Proceedings. 
No injunction or order shall be in effect prohibiting consummation of the
transactions contemplated hereby, and no action or proceeding by or before any
court or other governmental body shall have been instituted or threatened by
any governmental body or person whatsoever which shall seek to restrain,
prohibit or invalidate the transactions contemplated by this Agreement. No
federal, state, local or foreign statute, rule or regulation shall have been
enacted the effect of which would be to prohibit, restrict, impair or delay the
consummation of the transactions contemplated hereby.

                           8.5        Update. 
The Seller shall have provided the Buyer with a true, correct and complete list
and amount, as of the Interim Date, of the Accounts Receivable of BSA,
including an aging thereof, the Fixed Assets and the Inventory.

                           8.6        Closing Deliveries. 
The Buyer shall have received at or prior to the Closing each of the following
documents:

                                        (a)         a bill of sale substantially in the form attached hereto as Exhibit
C;

                                        (b)        such instruments of conveyance, assignment and transfer, in
form and substance reasonably satisfactory to the Buyer, as the Buyer shall
reasonably request, including without limitation patent, trademark and
copyright assignments;

                                        (c)         such certificates of the Seller’s officers and such other
documents evidencing satisfaction of the conditions specified in this Section 8
as the Buyer shall reasonably request;

                                        (d)        a certificate of the Secretary of the Seller attesting to the
incumbency of the Seller’s officers and the authenticity of the resolutions
authorizing the transactions contemplated by the Agreement;

                                        (e)         cross receipt executed by the Buyer and the Seller;

                                        (f)         opinions of counsel to the Seller and BSA in form reasonably
acceptable to Buyer and its counsel;

                                        (g)        a certified copy of the share transfer register (“registre des mouvement de titres”) and of
the shareholders accounts (“comptes
d’actionnaires”) evidencing that at Closing the Seller is the sole
owner of all of the BSA Shares;

                                        (h)        a share transfer form (“ordre
de mouvement de titres”) relating to the BSA Shares duly executed by
the Seller in favor of the Buyer;

                                        (i)          resignations of the officers and directors of BSA and BSG;

                                        (j)          copies of the by-laws and “extrait
K-bis” of BSA dated no earlier than 8 days before the date of the
Closing, certified by the Seller as true, correct and complete;

                                        (k)         a certified copy of the minutes (reproduced on the official
register) of the meeting of the Board of Directors of BSA approving (i) the
transfer of the BSA Shares and (ii) the Buyer as a new shareholder of BSA;

                                        (l)          a bill of sale substantially in the form attached hereto as
Exhibit E; and

                                        (m)        such other documents, instruments or certificates as the
Buyer may reasonably request.

                           8.7        Closing Balance Sheet. 
The Buyer shall have received the Closing Balance Sheet certified by the
Seller’s Vice President – Finance.

                           8.8        Collaboration Agreement.  The parties
shall have entered into a collaboration agreement covering the joint
development during the six-month period following the Closing, of a series of
proteomics products targeting the benchtop biologist.

                           8.9        Opinion of Works Council.  An opinion of
the works council (“comité d’ enterprise”)
of BSA, as described in Schedule 2.3 of the Disclosure Schedule, shall
have been delivered to BSA.

                           8.10      Governmental Approvals.  All governmental
agencies, departments, bureaus, commissions and similar bodies, with which a
filing or notification must be made or given or whose consent, authorization or
approval is necessary under any applicable law, rule, order or regulation for
the consummation by the Seller of the transactions contemplated by this
Agreement shall have consented to, authorized, permitted or approved such
transactions, and such consents, authorizations, approvals, filings or
notifications shall be reasonably satisfactory to the Buyer and its counsel,
and copies thereof shall be delivered to the Buyer at or prior to the Closing.

             9.          Conditions to
Obligations of the Seller.

             The obligations of the Seller under this Agreement are
subject to the fulfillment, on or before the Closing Date, of the following
conditions precedent, each of which may be waived in writing at the sole
discretion of the Seller:

                           9.1        Continued Truth of
Representations
and Warranties of the Buyer; Compliance with Covenants and Obligations. 
The representations and warranties of the Buyer contained in this Agreement
(including the Schedules hereto) shall be true in all respects on and as of the
Closing Date as though such representations and warranties were made on and as
of such date, except for any representation or warranty which speaks as of a
specified date, in which case such representation or warranty shall be true in
all respects as if made on such specified date, and except in any case for any inaccuracies
of representations and warranties that individually and in the aggregate have
not had or would not have a Material Adverse Effect. The Buyer shall have
performed and complied in all material respects with all covenants, obligations, and agreements
required by this Agreement to be performed or complied with by it prior to or
at the Closing Date.

                           9.2        Corporate Proceedings. 
All corporate and other proceedings required to be taken on the part of the
Buyer to authorize or carry out this Agreement shall have been taken and shall
be reasonably satisfactory to Seller and its counsel.

                           9.3        Consents of Third
Parties. 
The Buyer shall have received all requisite consents and approvals and shall
have made all requisite notifications or filings set forth on Schedule 3.2
and copies thereof shall be delivered to the Seller at or prior to the Closing.

                           9.4        Adverse Proceedings. 
No injunction or order shall be in effect prohibiting consummation of the
transactions contemplated hereby, and no action or proceeding by or before any
court or other governmental body shall have been instituted or threatened by
any governmental body or person whatsoever which shall seek to restrain,
prohibit or invalidate the transactions contemplated by this Agreement or which
might affect the right of the Seller to transfer the Assets. No federal, state,
local or foreign statute, rule or regulation shall have been enacted the effect
of which would be to prohibit, restrict, impair or delay the consummation of
the transactions contemplated hereby.

                           9.5        Closing Deliveries. 
The Seller shall have received at or prior to the Closing each of the following
documents:

                                        (a)         such certificates of the Buyer’s officers and such other
documents evidencing satisfaction of the conditions specified in this Section 9
as the Seller shall reasonably request;

                                        (b)        a certificate of the Secretary of the Buyer attesting to the
incumbency of the Buyer’s officers and the authenticity of the resolutions
authorizing the transactions contemplated by this Agreement;

                                        (c)         Instrument of Assumption of Liabilities executed by the
Buyer;

                                        (d)        payment of the Purchase Price, as adjusted in accordance with
the terms of this Agreement;

                                        (e)         cross receipt executed by the Buyer and the Seller;

                                        (f)         an opinion of counsel to the Buyer in form reasonably
acceptable to Seller and its counsel; and

                                        (g)        such other documents, instruments or certificates as the
Seller may reasonably request.

                           9.6        Collaboration Agreement.  The parties
shall have entered into a collaboration agreement covering the joint
development during the six-month period following the Closing, of a series of
proteomies products targeting the benchtop biologist.

                           9.7        Opinion of Works Council.  An opinion of
the works council (“comité d’ enterprise”)of
BSA, as described in Schedule 2.3 of the Disclosure Schedule, shall have
been delivered to BSA.

                           9.8        Governmental Approvals.  All governmental
agencies, departments, bureaus, commissions and similar bodies, with which a
filing or notification must be made or given or whose consent, authorization or
approval is necessary under any applicable law, rule, order or regulation for
the consummation by the Buyer of the transactions contemplated by this
Agreement shall have consented to, authorized, permitted or approved such
transactions, and such consents, authorizations, approvals, filings or
notifications shall be reasonably satisfactory to the Seller and its counsel,
and copies thereof shall be delivered to the Seller at or prior to the Closing.

             10.        Termination of
Representations and Warranties. 
All representations and warranties made by the parties herein, in the Schedules
hereto or in any instrument or document furnished pursuant to this Agreement
shall survive the Closing in accordance with Section 14 below. All covenants
made by the parties herein, in the Schedules hereto or in any instrument or
document furnished pursuant to this Agreement shall survive the Closing.

             11.        Post-Closing Agreements.

                           11.1      Proprietary Information. 
The Seller agrees that from and after the Closing Date the Seller shall hold in
confidence, and shall cause its officers, directors and personnel to hold in
confidence, all knowledge and information of a secret or confidential nature
with respect to the Business and shall not disclose, publish or make use of the
same without the consent of the Buyer, except to the extent that such
information shall have become public knowledge other than by breach of this
Agreement by the Seller.

             The Seller agrees that the remedy at law for any breach
of this Section 11 would be inadequate and that the Buyer shall be entitled to
seek injunctive relief in addition to any other remedy it may have upon breach
of any provision of this Section 11.

                           11.2      No Solicitation or
Hiring of Former Employees. 
Except with respect to employees of Buyer, BSA or BSG who, following the
Closing, may be terminated by Buyer, BSA or BSG for a period of two years after
the Closing Date, the Seller shall not solicit any person who was an employee
of either the Seller (solely with respect to the Business), BSA or BSG on the
date hereof or on the Closing Date to terminate his or her employment with the
Buyer, BSA or BSG or any of their affiliates or to become an employee of either
the Seller or any of its affiliates.

                           11.3      Non-Competition
Agreement.

                                        (a)         For a period of three years after the Closing Date, neither
the Seller nor any affiliate thereof shall, directly or indirectly, as owner,
partner, joint venturer, stockholder, or in any capacity whatsoever engage in,
become financially interested in, render any consultation or business advice
with respect to, or have any connection with any business involving process
scale chromatographic purification of proteins, in the United States or any
other country in which the Seller or any affiliate thereof conducted such
business during the two years prior to the Closing Date. Notwithstanding the
foregoing, Buyer acknowledges that Seller and its affiliates are engaged
worldwide in the provision of raw materials for process scale production of
proteins and agrees that, in relation to such activities, Seller and its
affiliates may engage in relationships with vendors of materials useful for
process scale chromatographic purification of proteins, including but not
limited to Buyer, and that such activities shall not constitute a violation of
the foregoing non-competition provision. In addition, Buyer acknowledges and
agrees that, in furtherance of the business of the Seller and its affiliates to
sell raw materials for process scale production of proteins, Seller and its
affiliates may make recommendations to their customers relative to materials
for process scale chromatographic purification of proteins, and that such
activities shall not constitute a violation of the foregoing non-competition
provision.  Further, Buyer recognizes
that an affiliate of Seller based in New Zealand makes and sells directly and
through Seller and its other affiliates certain chromatographic materials for
process scale chromatography of proteins, generally for customer applications
different than those addressed by the Business.  The continuation, growth and diversification of such business by
Seller and its affiliates shall not constitute a breach of the foregoing non-competition
provision, provided that neither Seller nor any of its affiliates shall employ
in such business any intellectual property purchased hereunder by Buyer and
shall not through this New Zealand affiliate or otherwise make, sell or
distribute chromatographic materials for process scale chromatography of
proteins for customer applications directly equivalent to those addressed by
the Business without the prior written consent of Buyer.

                                        (b)        The Seller hereby waives, to the extent permitted by law, any
and all right to contest the validity of this Section 11.3 on the ground of the
breadth of its geographic or product and service coverage or length of
term.  The Seller agrees that damages
are an inadequate remedy for any breach of this provision and that the Buyer
shall, whether or not it is pursuing any potential remedies at law, be entitled
to seek equitable relief in the form of preliminary and permanent injunctions
upon any breach of this non-competition provision.

                           11.4      Use of Name. 
Following the Closing Date, the Seller agrees not to use, and to cause its
affiliates not to use, the name “BioSepra” or any derivation thereof or any
name which is confusingly similar thereto or any other tradenames or trademarks
of Seller used solely in the Business in connection with any business whatsoever;
provided, however, that Seller shall be entitled to use such names following
the Closing Date solely to the extent that the names appear on business and
financial reports and catalogs of the Seller printed prior to the Closing Date.  Notwithstanding the foregoing, following the Closing Date,
Seller shall not initiate any new business relationships of any form under such
names.

                           11.5      Cooperation in
Litigation. 
Each party hereto will cooperate with the other in the defense or prosecution
of any litigation or proceeding already instituted or which may be instituted
hereafter against or by such party relating to or arising out of the conduct of
the Business prior to or after the Closing Date (other than litigation arising
out of the transactions contemplated by this Agreement). The party requesting
such cooperation shall pay the out-of- pocket expenses (including reasonable
legal fees and disbursements) of the party providing such cooperation and of
its officers, directors, employees and agents reasonably incurred in connection
with providing such cooperation, but shall not be responsible to reimburse the
party providing such cooperation for such party’s time spent in such
cooperation or the salaries or costs of fringe benefits or similar expenses
paid by the party providing such cooperation to its officers, directors,
employees and agents while assisting in the defense or prosecution of any such
litigation or proceeding.

                           11.6      Access to Books and
Records. 
The Seller shall have the right for a period of six years following the Closing
Date to have reasonable access, upon prior written notice, to such books,
records and accounts, including financial and tax information, correspondence,
production records, employment records and other records that are transferred
to the Buyer pursuant to the terms of this Agreement. The Buyer shall not
destroy any such books, records or accounts retained by it without first
providing the Seller with the opportunity to obtain or copy such books, records
or accounts.

                           11.7      Intangible Property
Cooperation. 
The Seller covenants and agrees that, at the request of the Buyer, the Seller
will communicate to the Buyer all information known to the Seller relating to
the Intangible Property transferred hereby, and that, at the expense of the
Buyer, the Seller will execute and deliver any papers, make all rightful oaths,
testify in any legal proceedings and perform all other lawful acts reasonably
deemed necessary by the Buyer to obtain, register, patent, perfect title,
enforce or defend such Intangible Property or to assist the Buyer in defending against claims related to
such Intangible Property in the United States and worldwide.

                           11.8      Beckman Obligations. 
Buyer acknowledges that Seller is obligated to make available to Beckman
Instruments, Inc. (“Beckman”) certain products, as set forth in Exhibit D hereto.  Buyer covenants and agrees from and after
the Closing Date to make available to Beckman, on the terms set forth in Exhibit
D, such quantities of the Products (as such term is defined in such
Exhibit) as may be requested by Beckman from time to time following the
Closing.

             12.        Termination of Agreement.

                           12.1      Termination by Lapse of
Time. 
This Agreement may be terminated by either the Buyer or the Seller, if the
transactions contemplated hereby have not been consummated within 60 days of
the date hereof, unless such date is extended by the written consent of the
parties hereto (provided that the right to terminate this Agreement under this
Section 12.1 shall not be available to any party whose failure to fulfill any
obligation under this Agreement has been the cause of or resulted in the
failure of the conditions precedent to the transactions contemplated by this
Agreement to occur on or before such date and such failure constitutes a breach
of this Agreement).

                           12.2      Termination by Agreement
of the Parties. 
This Agreement may be terminated by the mutual written agreement of the parties
hereto.

                           12.3      Termination by Buyer or
Seller By Reason of Breach. 
This Agreement may be terminated by the Seller, if at any time prior to the
Closing there shall occur a material breach of any of the representations,
warranties or covenants of the Buyer or the failure by the Buyer to perform any
material condition or obligation hereunder, and may be terminated by the Buyer,
if at any time prior to the Closing there shall occur a material breach of any
of the representations, warranties or covenants of the Seller or the failure of
the Seller to perform any material condition or obligation hereunder; provided
that in either case the party alleged to be in material breach shall have
received written notice of such material breach or material nonperformance and
such material breach or material non-performance has remained uncured for a
period of ten (10) days after such notice has been received.

                           12.4      Effect of Termination. 
In the event of termination of this Agreement as provided herein, this
Agreement shall immediately become void and there shall be no liability or
obligation on the part of either the Seller or the Buyer, or their subsidiaries
and their respective officers, directors, stockholders or affiliates, except to
the extent that such termination results from the willful breach by a party of
any of its representations, warranties or covenants set forth in this
Agreement; provided that the provisions of Section 4.3 and Section 13 of this
Agreement shall remain in full force and effect and survive any termination of
this Agreement.

             13.        Fees and Expenses.

                                        (a)         Except as set forth in this Section 13, the Buyer and the
Seller shall each pay their own expenses in connection with this Agreement and
the transactions contemplated hereby.

                                        (b)        The Buyer shall pay all expenses related to the relocation
after Closing of the Inventory transferred to Buyer under this Agreement.

             14.        Indemnification.

                           14.1      Survival of
Representations and Warranties. 
All of the representations and warranties contained in this Agreement shall
survive the Closing hereunder and continue in full force and effect for a
period of twelve (12) months thereafter, provided, however, that (i) that the
representations and warranties relating to Taxes and compliance with
Environmental Laws shall survive and remain in full force and effect for the
period equal to the statute of limitations relating thereto in the applicable
jurisdiction; and (ii) the representations and warranties set forth in Sections
2.2 and 2.4 (insofar as they relate to the ownership of the BSA
Shares, the BSG Shares and the Assets), 2.22, 3.2 and 3.4 shall survive and remain
in full force and effect without any limitation; and provided, further, that
any representation or warranty with respect to which a bona fide written claim
shall have been made or an action at law or in equity shall have commenced
before such date, shall survive (but only with respect to, and to the extent
of, such claim) until the final resolution of such claim or action, including
all applicable periods for appeal.

                           14.2      Indemnification
Provisions for Benefit of Buyer.  In
the event Seller breaches (or in the event any third party alleges facts that,
if true, would mean Seller has breached) any of its representations, warranties
and covenants contained herein, and Buyer makes a written claim for
indemnification against Seller within the applicable survival period, then
Seller agrees to indemnify Buyer and its affiliates and their respective
officers, directors and stockholders (each, a “Buyer Indemnified Party”) from
and against the entirety of any Adverse Consequences (as hereinafter defined)
they may suffer through and after the date of the claim for indemnification
(including any after the end of any applicable survival period) resulting from,
arising out of, or relating to the breach (or the alleged breach); provided,
however, that Seller shall not have any obligation to indemnify any Buyer
Indemnified Party from and against any Adverse Consequences resulting from,
arising out of, or relating to the breach (or alleged breach) of any
representation or warranty of Seller until the Buyer Indemnified Parties have,
in the aggregate, suffered Adverse Consequences by reason of all such breaches
(or alleged breaches) in excess of a $150,000 (the “Basket Amount”) aggregate
threshold (at which point Seller will be obligated to indemnify the Buyer
Indemnified Parties from and against all Adverse Consequences in excess of the
threshold amount) and provided further that Seller’s maximum liability arising
out of the transactions contemplated by this Agreement shall not exceed the
Purchase Price (the “Seller’s Liability Limitation”), except for fraud.  “Adverse Consequences” means all actions,
suits, proceedings, hearings, investigations, charges, complaints, claims,
demands, injunctions, judgments, orders, decrees, rulings, damages, dues,
penalties, fines, costs, amounts paid in settlement (with the approval of the
other party if required pursuant to the provisions of this Section 14),
liabilities, obligations, Taxes, liens, losses, expenses and fees, including
court costs and reasonable attorneys’ fees and expenses incurred in
investigation or defense of any of the same or asserting its rights hereunder.  Notwithstanding anything to the contrary in
the foregoing, solely for purposes of determining whether a Buyer Indemnified
Party has suffered Adverse Consequences resulting from a breach of the
representation and warranty of Seller contained in Section 2.15 hereof,
such representation and warranty shall be deemed to be made without any
materiality qualifiers.

                                        (a)         Seller agrees to indemnify the Buyer Indemnified Parties
from and against the entirety of any Adverse Consequences they may suffer
resulting from, arising out of, or relating to, any liability of Seller which
is not an Assumed Liability.

                           14.3      Indemnification
Provisions for Benefit of Seller. 
In the event Buyer breaches (or in the event any third party alleges facts
that, if true, would mean Buyer has breached) any of its representations,
warranties and covenants contained herein, and Seller makes a written claim for
indemnification against Buyer within the applicable survival period, then Buyer
agrees to indemnify Seller and its affiliates and their respective officers,
directors and stockholders (each, a “Seller Indemnified Party”) from and
against the entirety of any Adverse Consequences they may suffer through and
after the date of the claim for indemnification (including any Adverse
Consequences after the end of any applicable survival period) resulting from,
arising out of, or relating to the breach (or the alleged breach); provided,
however, that Buyer shall not have any obligation to indemnify any Seller
Indemnified Party from and against any Adverse Consequences resulting from,
arising out of, or relating to the breach (or alleged breach) of any representation or warranty of
Buyer until the Seller Indemnified Parties have, in the aggregate, suffered
Adverse Consequences by reason of all such breaches (or alleged breaches) in
excess of the Basket Amount (at which point Buyer will be obligated to
indemnify the Seller Indemnified Parties from and against all Adverse
Consequences in excess of the Basket Amount), and provided further that Buyer’s
maximum liability arising out of the transactions contemplated by this
Agreement shall not exceed the Purchase Price, except for fraud.

                                        (a)         Buyer agrees to indemnify the Seller Indemnified Parties
from and against the entirety of any Adverse Consequences they may suffer
resulting from, arising out of, or relating to any Assumed Liability.

                           14.4      Matters Involving Third
Parties. 
If any third party shall notify any Buyer Indemnified Party or any Seller
Indemnified Party (the “Indemnified Party”) with respect to any matter (a
“Third Party Claim”) which may give rise to a claim for indemnification against
any other party (the “Indemnifying Party”) under this Section 14, then the
Indemnified Party shall promptly notify the Indemnifying Party thereof in
writing; provided, however, that no delay on the part of the Indemnified Party
in notifying the Indemnifying Party shall relieve the Indemnifying Party from
any obligation hereunder unless (and then solely to the extent) the
Indemnifying Party thereby is prejudiced.

                                        (a)         Any Indemnifying Party will have the right to defend the
Indemnified Party against the Third Party Claim with counsel of its choice
reasonably satisfactory to the Indemnified Party so long as (i) the
Indemnifying Party notifies the Indemnified Party in writing within fifteen
(15) days after the Indemnified Party has given notice of the Third Party Claim
that the Indemnifying Party will indemnify the Indemnified Party from and
against the entirety of any Adverse Consequences the Indemnified Party may
suffer resulting from, arising out of or relating to the Third Party Claim, and
(ii) the Indemnifying Party conducts the defense of the Third Party Claim actively
and diligently.

                                        (b)        So long as the Indemnifying Party is conducting the defense
of the Third Party Claim in accordance with Section 14.4(b) above, (i) the
Indemnified Party may retain separate co-counsel at its sole cost and expense
and participate in the defense of the Third Party Claim, (ii) the Indemnified
Party will not consent to the entry of any judgment or enter into any
settlement with respect to the Third Party Claim without the prior written
consent of the Indemnifying Party (not to be withheld, delayed or conditioned
unreasonably) provided that the Indemnifying Party shall not be required to
consent to any judgment or settlement unless it shall provide for a full
release of such Indemnifying Party without liability or obligation, and (iii)
the Indemnifying Party will not consent to the entry of any judgment or enter
into any settlement with respect to the Third Party Claim without the prior
written consent of the Indemnified Party (not to be withheld, delayed or
conditioned unreasonably), provided that the Indemnified Party shall not be
required to consent to any judgment or settlement unless it shall provide for a
full release of such Indemnified Party without liability or obligation.

                                        (c)         In the event any of the conditions in Section 14.4(b) above
is or becomes unsatisfied, however, (i) the Indemnified Party may defend
against, the Third Party Claim, and (ii) the Indemnifying Party will reimburse
the Indemnified Party promptly and periodically for the costs of defending
against the Third Party Claim (including reasonable attorneys’ fees and
expenses).

                           14.5      Adjustments to
Indemnification Payments. 
Any payment made by one party to another party pursuant to this Section 14 in
respect of any claim shall be net of (i) any tax benefit realized by such party
as a result of such party’s deduction of such payment for federal and/or state
income tax purposes, and (ii) any insurance proceeds realized by and paid to
the Indemnified Party in respect of such claim.

                           14.6      Mitigation of Loss. 
The party entitled to indemnification shall take all commercially reasonable
steps to mitigate all Adverse Consequences upon and after becoming aware of any
event that would be reasonably likely to give rise to any Adverse Consequences
that are indemnifiable hereunder.

                           14.7      Remedies. 
Other than for claims of fraud, and any right to specific performance or
injunctive relief which may exist under Section 4.2 and Section 11, the right
of each party to seek indemnification from the other party pursuant to Section 14
shall be the sole and exclusive right of each party against the other party for
any breach of any representation, warranty or covenant contained herein.

                                        (a)         No party shall be liable to the other party for
indemnification pursuant to Section 14 or otherwise for breach of a
representation or warranty which breach (or the facts giving rise to such
breach) was known by or disclosed in writing to the other party at or prior to
the Closing Date.

             15.        Transfer and Sales Tax.

             Each of the Seller, BSA and the Buyer, as the case may
be, shall be responsible for and shall pay (a) all sales, use and transfer
Taxes, and (b) all governmental charges, if any, upon the sale or transfer of
any of the Assets hereunder, in each case, to the extent such party is required
by local law or custom to pay such Taxes or charges.  In furtherance of the foregoing, and not by way of limitation
thereof, Buyer shall pay any transfer Taxes under French law relating to or
arising out of the Buyer’s purchase of the BSA Shares within one (1) month of
the Closing Date. If the Buyer or the Seller, as the case may be, shall fail to
pay such amounts on a timely basis, the other party may pay such amounts to the
appropriate governmental authority or authorities, and the Buyer or the Seller,
as the case may be, shall promptly reimburse such other party for any amounts
so paid.

             16.        Notices.

             Any notices or other communications required or
permitted hereunder shall be sufficiently given if delivered personally or sent
by federal express or comparable courier service, registered or certified mail,
postage prepaid, addressed as follows or to such other address of which the
parties may have given notice:

	To
  the Seller	Invitrogen
  Corporation
	 	1600
  Faraday Avenue
	 	Carlsbad,
  California  92008
	 	Attn:  General Counsel
	 	 
	With
  a copy to:	Fulbright
  & Jaworski L.L.P.
	 	666
  Fifth Avenue
	 	New
  York, New York  10103
	 	Attn:  Mara H. Rogers, Esq.
	 	 
	To
  the Buyer:	Ciphergen
  Biosystems, Inc.
	 	6611
  Dumbarton Circle
	 	Fremont,
  California 94555
	 	Attn:
  Matthew Hogan
	 	 
	With
  copies to:	Wilson
  Sonsini Goodrich & Rosati
	 	650
  Page Mill Road
	 	Palo
  Alto, California 94304
	 	Attn:  Michael O’ Donnell, Esq.

             Unless otherwise specified herein, such notices or other
communications shall be deemed received (a) on the date delivered, if delivered
personally; (b) five business days after being sent, if sent by registered or
certified mail or (c) two business days after being sent by federal express or
comparable courier service.

             17.        Successors and Assigns.

             This Agreement shall be binding upon and inure to the
benefit of the parties hereto and their respective successors and assigns,
except that the Buyer and the Seller may not assign their respective
obligations hereunder without the prior written consent of the other party;
provided, however, that the Buyer may assign this Agreement, and its rights and
obligations hereunder, to a subsidiary or affiliate of Buyer. Any assignment in
contravention of this provision shall be void. No assignment shall release the
Buyer from any obligation or liability under this Agreement.

             18.        Entire Agreement;
Amendments; Attachments.

                                        (a)         This Agreement, all Schedules and Exhibits hereto, and all
agreements and instruments to be delivered by the parties pursuant hereto
represent the entire understanding and agreement between the parties hereto
with respect to the subject matter hereof and supersede all prior oral and
written and all contemporaneous oral negotiations, commitments and
understandings between such parties. The Buyer and the Seller may amend or
modify this Agreement, in such manner as may be agreed upon, by a written
instrument executed by the Buyer and the Seller.

                                        (b)        The Exhibits and Schedules attached hereto or to be attached
hereafter are hereby incorporated as integral parts of this Agreement.

             19.        Governing Law.

             This Agreement shall be governed by and construed in
accordance with the laws of the State of Delaware, without regard to the
conflicts of laws principles thereof.

             20.        Section Heading.

             The section headings are for the convenience of the
parties and in no way alter, modify, amend, limit, or restrict the contractual
obligations of the parties.

             21.        Severability.

             The invalidity or unenforceability of any provision of
this Agreement shall not affect the validity or enforceability of any other
provision of this Agreement.

             22.        Counterparts.

             This Agreement may be executed in two counterparts, each
of which shall be deemed to be an original, but both of which shall be one and
the same document.

             23.        No Third Party Beneficiaries.

             Except as set forth in Section 14, nothing herein
expressed or implied is intended or shall be construed to confer upon or give
to any person other than the parties hereto and their successors or assigns any
rights or remedies under or by reason of this Agreement.

             24.        Translations.

             Solely as a courtesy to Buyer, Seller has provided Buyer
with and will continue to provide Buyer with (in accordance with Section 4.1)
English translations which are in Seller’s possession (the “Translations”) of certain
French language Contracts and other documents relating to the Business (the
“French Documents”).  The parties hereby
agree that (i) Seller makes no representation, warranty or covenant regarding
the accuracy, completeness or truthfulness of the Translations, (ii) Buyer has
had the opportunity to review the French language versions of the French
Documents in their entirety and to have the French Documents translated on
its behalf and has not relied on the Translations in making its decision to
enter into this Agreement, (iii) a reference to any of the French Documents,
whether in this Agreement, the Exhibits or Schedules hereto or any of the other
agreements contemplated hereby, shall be deemed a reference to the French
language version of such French Document and not to the Translation thereof and
(iv) in any dispute between the parties relating to any French Document
(whether such dispute is an Adverse Consequence or not), the French language
version of such French Document, and not the Translation or any other
translation thereof, shall control.

             IN WITNESS WHEREOF, this Agreement has been duly
executed by the parties hereto as of and on the date first above written.

	 	CIPHERGEN
  BIOSYSTEMS, INC.
	 	 	 
	 	 	 
	 	By:	/s/
  William E. Rich
	 	 	

 
	 	Name:   	William
  E. Rich
	 	 	

 
	 	Title:    	President
  & CEO
	 	 	

 
	 	 	 
	 	INVITROGEN
  CORPORATION
	 	 	 
	 	 	 
	 	By:	/s/
  John D. Thompson
	 	 	

 
	 	Name:  	 John D. Thompson
	 	 	

 
	 	Title:
  	Vice
  President, Corporate DevelopmentPrepared by MerrillDirect

Exhibit 10.1

LIGHTBRIDGE, INC.

Amendments to the 1996 Stock
Purchase Plan, as Amended

	1)	Effective
  March 16, 2001, Paragraph 3(b) of the Lightbridge, Inc. 1996 Stock Purchase
  Plan, as amended, was further amended by deleting the words “six months” in
  the first sentence thereof and substituting therefor the words “ twenty
  days.”
	 	 
	2)	Effective
  May 29, 2001, Paragraph 11(a) of the Lightbridge, Inc. 1996 Stock Purchase
  Plan, as amended, was further amended by deleting the number “200,000” in the
  first sentence thereof and substituting therefor the number “400,000.”

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