Document:

exv10w20

Exhibit 10.20

SECOND AMENDMENT TO LEASE

     THIS SECOND AMENDMENT TO LEASE (this “Second Amendment”) is made as of December 21, 2009, by
and between ARE-SD REGION NO. 20, LLC, a Delaware limited liability company (“Landlord”), and
CYPRESS BIOSCIENCE, INC., a Delaware corporation (“Tenant”).

RECITALS

     A. Landlord and Tenant are parties to that certain Lease Agreement dated as of May 23, 2008,
as amended by that certain First Amendment to Lease Agreement dated as of March 11, 2009 (as so
amended, the “Lease”). Pursuant to the Lease, Tenant agreed to lease certain premises consisting
of approximately 2,455 rentable square feet (“Premises”) in a building located at 9393 Towne Centre
Drive, San Diego, California. The Premises are more particularly described in the Lease.
Capitalized terms used herein without definition shall have the meanings defined for such terms in
the Lease.

     B. The Base Term of the Lease is scheduled to expire on December 31, 2009.

     C. Landlord and Tenant desire, subject to the terms and conditions set forth below, to amend
the Lease to, among other things, (i) extend the Base Term and (ii) decrease the Base Rent.

     NOW, THEREFORE, in consideration of the foregoing Recitals, which are incorporated herein by
this reference, the mutual promises and conditions contained herein, and for other good and
valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Landlord and
Tenant hereby agree as follows:

	1.	 	Base Term. The defined term “Base Term” on page 1 of the Lease is hereby deleted in
its entirety and replaced with the following:

               “Base Term: Beginning on the Commencement Date and ending on June 30, 2010.”

	2.	 	Base Rent. Tenant shall continue to pay Base Rent as provided for in the Lease
through December 31, 2009. Commencing on January 1, 2010, Tenant shall pay Base Rent in the
amount of $6,383.00 per month through the expiration of the Base Term.
	 
	3.	 	Brokers. Landlord and Tenant each represents and warrants that it has not,
with the exception of BRE Commercial, Inc., dealt with any broker, agent or other person
(collectively, “Broker”) in connection with the transaction reflected in this Second Amendment
and that no Broker, other than BRE Commercial, Inc., brought about this transaction, other
than BRE Commercial, Inc. (dba Grubb & Ellis/BRE Commercial). Landlord and Tenant each hereby
agree to indemnify and hold the other harmless from and against any claims by any Broker,
other than the broker, if any named in this Second Amendment, claiming a commission or other
form of compensation by virtue of having dealt with Tenant or Landlord, as applicable, with
regard to this leasing transaction.
	 
	4.	 	Miscellaneous.

	 	a.       This Second Amendment is the entire agreement between the parties with respect to the
subject matter hereof and supersedes all prior and contemporaneous oral and written
agreements and discussions. This Second Amendment may be amended only by an agreement in
writing, signed by the parties hereto.

	 
	

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	 	b.       This Second Amendment is binding upon and shall inure to the benefit of the parties
hereto, their respective agents, employees, representatives, officers, directors,
divisions, subsidiaries, affiliates, assigns, heirs, successors in interest and
shareholders.
	 
	 	c.       This Second Amendment may be executed in any number of counterparts, each of which
shall be deemed an original, but all of which when taken together shall constitute one and
the same instrument. The signature page of any counterpart may be detached therefrom
without impairing the legal effect of the signature(s) thereon provided such signature
page is attached to any other counterpart identical thereto except having additional
signature pages executed by other parties to this Second Amendment attached thereto.
	 
	 	d.       Except as amended and/or modified by this Second Amendment, the Lease is hereby
ratified and confirmed and all other terms of the Lease shall remain in full force and
effect, unaltered and unchanged by this Second Amendment. In the event of any conflict
between the provisions of this Second Amendment and the provisions of the Lease, the
provisions of this Second Amendment shall prevail.

[Signatures are on the next page.]

	 
	

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     IN WITNESS WHEREOF, the parties hereto have executed this Second Amendment as of the day and
year first above written.

	 	 	 	 	 
	LANDLORD:	ARE-SD REGION NO. 20, LLC,

a Delaware limited liability company

 	 
	 	By:  	ARE-SD REGION NO. 20 MEMBER, LLC,
 	 
	 	 	a Delaware limited liability company, 	 
	 	 	as Managing Member 	 

	 	 	 	 	 
	 	By:  	ALEXANDRIA REAL ESTATE EQUITIES, L.P., 	 
	 	 	a Delaware limited partnership, as Managing Member 	 

	 	 	 	 	 
	 	By:  	                                                             ARE-QRS CORP.,
 	 
	 	 	a Maryland corporation, 	 
	 	 	as General Partner 	 

	 	 	 	 	 
	 	By:  	                                                /s/ Gary Dean
 	 
	 	Its:        VP- Legal Affairs 	 

	 	 	 	 	 
	TENANT:	CYPRESS BIOSCIENCE, INC.,

a Delaware corporation

 	 
	 	By:  	/s/ Sabrina Johnson
 	 
	 	Its:                     CFO/COOexv10w21

Exhibit 10.21

FOURTH AMENDMENT

     THIS FOURTH AMENDMENT (the “Amendment”) is made and entered into as of December 29, 2009, by
and between UTC PROPERTIES LLC, a Delaware limited liability company, (“Landlord”) and CYPRESS
BIOSCIENCE, INC., a Delaware corporation (“Tenant”).

RECITALS

	A.	 	Landlord (as successor in interest to CA-Park Plaza Limited Partnership, a Delaware limited
partnership, as successor by conversion to EOP-Park Plaza, L.L.C., a Delaware limited
liability company) and Tenant are parties to that certain lease dated July 10, 2002, which
lease has been previously amended by a First Amendment dated September 6, 2006, Second
Amendment dated July 30, 2008 and a Third Amendment dated March 17, 2009 (collectively, the
“Lease”). Pursuant to the Lease, Landlord has leased to Tenant space currently containing
approximately 7,565 rentable square feet (the “Premises”) described as Suite No. 315 (“Suite
315”), consisting of approximately 1,892 rentable square feet, and Suite No. 325, consisting
of approximately 5,673 rentable square feet, on the 3rd floor of the building
located at 4350 Executive Drive, San Diego, California (the “Building”).
	 
	B.	 	The Lease with respect to Suite 315 by its terms shall expire on December 31, 2009 (“Suite
315 Extended Termination Date”), the Lease with respect to Suite 325 by its terms shall expire
on July 31, 2012 and the parties desire to extend the Term of the Lease with respect to Suite
315 only, all on the following terms and conditions.

          NOW, THEREFORE, in consideration of the above recitals which by this reference are
incorporated herein, the mutual covenants and conditions contained herein and other valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant
agree as follows:

	I.	 	Suite 315 Extension. The Term of the Lease with respect to Suite 315 only is hereby
extended and shall expire on December 31, 2010 (the “Suite 315 Extended Expiration Date”),
unless sooner terminated in accordance with the terms of the Lease. That portion of the Term
commencing the day immediately following the Suite 315 Extended Termination Date (“Suite 315
Second Extension Date”) and ending on the Suite 315 Extended Expiration Date shall be referred
to herein as the “Suite 315 Second Extended Term”.
	 
	II.	 	Suite 315 Base Rent. As of the Suite 315 Second Extension Date, the schedule of Base
Rent payable with respect to the Premises during the Extended Term is the following:

	 	 	 	 	 
	 	 	Monthly Rate Per	 	 
	Months of Term or Period	 	Square Foot	 	Monthly Base Rent
	1/01/10 – 12/31/10
	 	$2.45
	 	$4,635.00

	 	 	 	 	All such Base Rent shall be payable by Tenant in accordance with the terms of the Lease.

	III.	 	Suite 315 Expenses and Taxes. For the period commencing on the Suite 315 Second
Extension Date and ending on the Suite 315 Extended Expiration Date, Tenant shall be obligated
to pay Tenant’s Pro Rata Share of Expenses and Taxes accruing in connection with Suite 315 in
accordance with the terms of the Lease, as previously amended in the Second Amendment.
	 
	IV.	 	Additional Security Deposit. No additional security deposit shall be required in
connection with this Amendment.
	 
	V.	 	Improvements to Premises.

	 	A.	 	Condition of Suite 315. Tenant is in possession of the Premises and
accepts the same “as is” without any agreements, representations, understandings or
obligations on the part of Landlord to perform any alterations, repairs or
improvements, except as may be expressly provided otherwise in this Amendment.
	 
	 	B.	 	Any construction, alterations or improvements to Suite 315 shall be performed
by Tenant at its sole cost and expense using contractors selected by Tenant and
approved by Landlord and shall be governed in all respects by the provisions of Article
IX of the Lease.

	VI.	 	Parking. During the Suite 315 Second Extended Term,      Tenant
shall continue to lease the Suite 315 parking spaces at
no charge through the Suite 315 Extended Expiration Date.
Thereafter, the stall charge shall be at Landlord’s scheduled
parking rates from time to time.
	 
	VII.	 	SDN List. Tenant hereby represents and warrants that neither
Tenant nor any officer, director, employee, partner, member or
other principal of Tenant (collectively, “Tenant Parties”) is
listed as a Specially Designated National and Blocked Person
(“SDN”) on the list of such persons and entities issued by the
U.S. Treasury Office of Foreign Assets Control (OFAC). In the
event Tenant or any Tenant Party is or becomes listed as an SDN,
Tenant shall be deemed in breach of

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	 	 	this Lease and Landlord
shall have the right to terminate the Lease immediately upon
written notice to Tenant.
	 
	VIII.	 	GENERAL.

	 	A.	 	Effect of Amendments. The Lease shall remain in full force and effect
except to the extent that it is modified by this Amendment.
	 
	 	B.	 	Entire Agreement. This Amendment embodies the entire understanding
between Landlord and Tenant and can be changed only by a writing signed by Landlord and
Tenant. There have been no additional oral or written representations or
agreements. Under no circumstances shall Tenant be entitled to any rent abatement,
improvement allowance, leasehold improvements, or any similar economic incentives that
may have been provided Tenant in connection with entering into the Lease, unless
specifically set forth in this Amendment.
	 
	 	C.	 	Counterparts. If this Amendment is executed in counterparts, each is hereby
declared to be an original; all, however, shall constitute but one and the same
amendment. In any action or proceeding, any photographic, photostatic, or other copy
of this Amendment may be introduced into evidence without foundation.
	 
	 	D.	 	Defined Terms. All words commencing with initial capital letters in
this Amendment and defined in the Lease shall have the same meaning in this Amendment
as in the Lease, unless they are otherwise defined in this Amendment.
	 
	 	E.	 	Authority. If Tenant is a corporation, limited liability company or
partnership, or is comprised of any of them, each individual executing this Amendment
for the corporation, limited liability company or partnership represents that he or she
is duly authorized to execute and deliver this Amendment on behalf of such entity and
that this Amendment is binding upon such entity in accordance with its terms.
	 
	 	F.	 	Attorneys’ Fees. The provisions of the Lease respecting payment of
attorneys’ fees shall also apply to this Amendment.
	 
	 	G.	 	Execution of Amendment. Submission of this Amendment by Landlord
is not an offer to enter into this Amendment but rather is a solicitation for such an
offer by Tenant. Landlord
shall not be bound by this Amendment until Landlord has executed and delivered the
same to Tenant.
	 
	 	H.	 	Nondisclosure of Terms. Tenant agrees that neither Tenant nor its
agents or any other parties acting on behalf of Tenant shall disclose any matters set
forth in this Amendment or disseminate or distribute any information concerning the
terms, details or conditions hereof to any person, firm or entity without obtaining the
express written consent of Landlord.

     IN WITNESS WHEREOF, Landlord and Tenant have duly executed this Amendment as of the day
and year first above written.

	 	 	 	 	 	 	 	 	 	 	 
	LANDLORD:	 	 	 	TENANT:	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	UTC PROPERTIES LLC,	 	 	 	CYPRESS BIOSCIENCE, INC.,	 	 
	a Delaware limited liability company	 	 	 	a Delaware corporation	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	By:

	 	/s/ Steven M. Case
	 	 	 	By:
	 	/s/  Sabrina Martucci Johnson	 	 
	 

	 	 
	 	 	 	 	 	 	 	 
	 	 	Steven M. Case	 	 	 	Printed Name: Sabrina Martucci Johnson	 	 
	 

	 	Executive Vice President, Leasing

Office Properties
	 	 	 	Title:
	 	COO and CFO	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	By:

	 	/s/  Michael T. Bennett
	 	 	 	By:
	 	/s/ Janna Sipes	 	 
	 

	 	 
	 	 	 	 	 	 	 	 
	 	 	Michael T. Bennett	 	 	 	Printed Name: Janna Sipes	 	 
	 

	 	Senior Vice President, Operations

Office Properties
	 	 	 	Title:
	 	VP, Compliance Officer and
Human Resources Executive	 	 

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