Document:

Loan and Security Agreement

 EXHIBIT 10.6 
 LOAN AND SECURITY AGREEMENT 
 Dated as of May 17, 2007 
 between 
 ENTEROMEDICS INC.,

 a Delaware corporation, 
 as “Borrower”, 
 and 
 VENTURE LENDING & LEASING IV, INC., 
 a Maryland corporation, 
 and 
 VENTURE LENDING &
LEASING V, INC., 
 a Maryland corporation, 
 each, as “Lender” 

 LOAN AND SECURITY AGREEMENT 
 The Borrower and each of Venture Lending & Leasing IV, Inc. (“VLL4”) and Venture Lending & Leasing V, Inc. (“VLL5”)
have entered or anticipate entering into one or more transactions pursuant to which each Lender severally and not jointly agrees to make available to Borrower a loan facility governed by the terms and conditions set forth in this document and one or
more Supplements executed by Borrower and Lender which incorporate this document by reference. Each Supplement constitutes a supplement to and forms part of this document, and will be read and construed as one with this document, so that this
document and the Supplement constitute a single agreement between the parties (collectively referred to as this “Agreement”). 
 Accordingly, the parties agree as follows: 
 ARTICLE 1—INTERPRETATION 
 1.1 Definitions. The terms defined in Article 10 and in the Supplement will have the meanings therein specified for purposes of this Agreement.

 1.2 Inconsistency. In the event of any inconsistency between the provisions of any Supplement and this document, the provisions of
the Supplement will be controlling for the purpose of all relevant transactions. 
 1.3 Several Obligations of Lender. The parties are
entering into this single Agreement for convenience, and this Agreement is and shall be interpreted for all purposes as separate and distinct agreements between Borrower and VLL4, on the one hand, and Borrower and VLL5, on the other hand, and
nothing in this Agreement shall be deemed a joint venture, partnership or other association between VLL4 and VLL5. Each reference in this Agreement to “Lender” shall mean and refer to each of VLL4 and VLL5, singly and independent of one
another. Without limiting the generality of the foregoing, the Commitment, covenants and other obligations of “Lender” under this Agreement are several and not joint obligations of VLL4 and VLL5, and all rights and remedies of
“Lender” under this Agreement may be exercised by VLL4 and/or VLL5 independently of one another. 
 ARTICLE 2 —THE COMMITMENT AND LOANS

 2.1 The Commitment. Subject to the terms and conditions of this Agreement, Lender agrees to make term loans to Borrower from
time to time from the Closing Date and to, but not including, the Termination Date in an aggregate principal amount not exceeding the Commitment. The Commitment is not a revolving credit commitment, and Borrower does not have the right to repay and
reborrow hereunder. Each Loan requested by Borrower to be made on a single Business Day shall be for a minimum principal amount set forth in the Supplement, except to the extent the remaining Commitment is a lesser amount. 
 2.2 Notes Evidencing Loans; Repayment. Each Loan shall be evidenced by a separate Note payable to the order of Lender, in the total principal
amount of the Loan. Principal and interest of each Loan shall be payable at the times set forth in the Note and regularly scheduled payments thereof and each Terminal Payment shall be effected by automatic debit of the appropriate funds from
Borrower’s Primary Operating Account as specified in the Supplement hereto. 
 2.3 Procedures for Borrowing. 
 (a) Borrower shall give Lender, at least five (5) Business Days’ prior to a proposed Borrowing Date, written notice of any request for borrowing
hereunder (a “Borrowing Request”). Each Borrowing Request shall be in substantially the form of Exhibit “B” to the Supplement, shall be executed by a responsible executive or financial officer of Borrower, and shall state
how much is requested, and shall be accompanied by such other information and documentation as Lender may reasonably request. 
 (b) No later
than 1:00 p.m. Pacific Standard Time on the Borrowing Date, if Borrower has satisfied the conditions precedent in Article 4, Lender shall make the Loan available to Borrower in immediately available funds. 
 2.4 Interest. Except as otherwise specified in the applicable Note, Basic Interest on the outstanding principal balance of each Loan shall accrue
daily at the Designated Rate from the Borrowing Date until the Maturity Date. If the outstanding principal balance of such Loan is not paid on the Maturity Date, interest shall accrue at the Default Rate until paid in full, as further set forth
herein. 

 2.5 Terminal Payment. Except as otherwise provided in the Supplement, Borrower shall pay the
Terminal Payment with respect to each Loan on the Maturity Date of such Loan. 
 2.6 Interest Rate Calculation. Basic Interest, along
with charges and fees under this Agreement and any Loan Document, shall be calculated for actual days elapsed on the basis of a 360-day year, which results in higher interest, charge or fee payments than if a 365-day year were used. In no event
shall Borrower be obligated to pay Lender interest, charges or fees at a rate in excess of the highest rate permitted by applicable law from time to time in effect. 
 2.7 Default Interest. Any unpaid payments of principal or interest or the Terminal Payment with respect to any Loan shall bear interest from their respective maturities, whether scheduled or accelerated, at the
Designated Rate for such Loan plus five percent (5.00%) per annum, until paid in full, whether before or after judgment (the “Default Rate”). Borrower shall pay such interest on demand. 
 2.8 Late Charges. If Borrower is late in making any payment of principal or interest or Terminal Payment under this Agreement by more than five
(5) days, Borrower agrees to pay a late charge of five percent (5%) of the installment due, but not less than fifty dollars ($50.00) for any one such delinquent payment. This late charge may be charged by Lender for the purpose of
defraying the expenses incidental to the handling of such delinquent amounts. Borrower acknowledges that such late charge represents a reasonable sum considering all of the circumstances existing on the date of this Agreement and represents a fair
and reasonable estimate of the costs that will be sustained by Lender due to the failure of Borrower to make timely payments. Borrower further agrees that proof of actual damages would be costly and inconvenient. Such late charge shall be paid
without prejudice to the right of Lender to collect any other amounts provided to be paid or to declare a default under this Agreement or any of the other Loan Documents or from exercising any other rights and remedies of Lender. 
 2.9 Lender’s Records. Principal, Basic Interest, Terminal Payments and all other sums owed under any Loan Document shall be evidenced by
entries in records maintained by Lender for such purpose. Each payment on and any other credits with respect to principal, Basic Interest, Terminal Payments and all other sums outstanding under any Loan Document shall be evidenced by entries in such
records. Absent manifest error, Lender’s records shall be conclusive evidence thereof. 
 2.10 Grant of Security Interests; Filing of
Financing Statements. 
 (a) To secure the timely payment and performance of all of Borrower’s Obligations to Lender, Borrower
hereby grants to Lender continuing security interests in all of the Collateral. In connection with the foregoing, Borrower authorizes Lender to prepare and file any financing statements describing the Collateral without otherwise obtaining the
Borrower’s signature or consent with respect to the filing of such financing statements. 
 (b) Borrower is and shall remain
absolutely and unconditionally liable for the performance of its obligations under the Loan Documents, including, without limitation, any deficiency by reason of the failure of the Collateral to satisfy all amounts due Lender under any of the Loan
Documents. 
 (c) All Collateral pledged by Borrower under this Agreement and any Supplement shall secure the timely payment and
performance of all Obligations under this Agreement, the Notes and the other Loan Documents. Except as expressly provided in this Agreement, no Collateral pledged under this Agreement or any Supplement shall be released until such time as all
Obligations under this Agreement and the other Loan Documents have been satisfied and paid in full. 
 ARTICLE 3—REPRESENTATIONS AND WARRANTIES

 Borrower represents and warrants that, except as set forth in the Supplement or any schedule of exceptions executed by the parties, as
of the Closing Date and each Borrowing Date: 
 3.1 Due Organization. Borrower is a corporation duly organized and validly existing in
good standing under the laws of the jurisdiction of its incorporation, and is duly qualified to conduct business and is in good standing in each other jurisdiction in which its business is conducted or its properties are located, except where the
failure to be so qualified would not reasonably be expected to have a Material Adverse Effect. 
  

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 3.2 Authorization, Validity and Enforceability. The execution, delivery and performance of all
Loan Documents executed by Borrower are within Borrower’s powers, have been duly authorized, and are not in conflict with Borrower’s articles or certificate of incorporation or by-laws, or the terms of any charter or other organizational
document of Borrower, as amended from time to time; and all such Loan Documents constitute valid and binding obligations of Borrower, enforceable in accordance with their terms (except as may be limited by bankruptcy, insolvency and similar laws
affecting the enforcement of creditors’ rights in general, and subject to general principles of equity). 
 3.3 Compliance with
Applicable Laws. Borrower has complied with all licensing, permit and fictitious name requirements necessary to lawfully conduct the business in which it is engaged, and to any sales, leases or the furnishing of services by Borrower, including
without limitation those requiring consumer or other disclosures, the noncompliance with which would have a Material Adverse Effect. 
 3.4 No Conflict. The execution, delivery, and performance by Borrower of all Loan Documents are not in conflict with any law, rule, regulation, order or directive, or any indenture, agreement, or undertaking to which Borrower is a
party or by which Borrower may be bound or affected. Without limiting the generality of the foregoing, the issuance of the Warrant to Lender (or its designee) and the grant of registration rights in connection therewith do not violate any agreement
or instrument by which Borrower is bound or require the consent of any holders of Borrower’s securities other than consents which have been obtained prior to the Closing Date. 
 3.5 No Litigation, Claims or Proceedings. There is no litigation, tax claim, proceeding or dispute pending, or, to the knowledge of Borrower,
threatened against or affecting Borrower, its property or the conduct of its business. 
 3.6 Correctness of Financial Statements.
Borrower’s financial statements which have been delivered to Lender fairly and accurately reflect Borrower’s financial condition in accordance with GAAP as of the latest date of such financial statements; and, since that date there has
been no Material Adverse Change. 
 3.7 No Subsidiaries. Borrower is not a majority owner of or in a control relationship with any
other business entity. 
 3.8 Environmental Matters. To its knowledge after reasonable inquiry, Borrower has concluded that Borrower
is in compliance with Environmental Laws, except to the extent a failure to be in such compliance could not reasonably be expected to have a Material Adverse Effect. 
 3.9 No Event of Default. No Default or Event of Default has occurred and is continuing. 
 3.10
Full Disclosure. None of the representations or warranties made by Borrower in the Loan Documents as of the date such representations and warranties are made or deemed made, and none of the statements contained in any exhibit, report, statement
or certificate furnished by or on behalf of Borrower in connection with the Loan Documents (including disclosure materials delivered by or on behalf of Borrower to Lender prior to the Closing Date or pursuant to Section 5.2 hereof), contains
any untrue statement of a material fact or omits any material fact required to be stated therein or necessary to make the statements made therein, in light of the circumstances under which they are made, not misleading as of the time when made or
delivered. 
 3.11 Specific Representations Regarding Collateral. 
 (a) Title. Except for the security interests created by this Agreement and Permitted Liens, (i) Borrower is and will be the unconditional
legal and beneficial owner of the Collateral, and (ii) the Collateral is genuine and subject to no Liens, rights or defenses of others. There exist no prior assignments or encumbrances of record with the U.S. Patent and Trademark Office or
Copyright Office affecting any Collateral in favor of any third party. 
 (b) Rights to Payment. The names of the obligors, amount
owing to Borrower, due dates and all other information with respect to the Rights to Payment are and will be correctly stated in all material respects in all Records relating to the Rights to Payment. Borrower further represents and warrants, to its
knowledge, that each Person appearing to be obligated on a Right to Payment has authority and capacity to contract and is bound as it appears to be. 
 (c) Location of Collateral. Borrower’s chief executive office, Inventory, Records, Equipment, and any other offices or places of business are located at the address(es) shown on the Supplement. 

 

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 (d) Business Names. Other than its full corporate name, Borrower has not conducted business
using any trade names or fictitious business names except as shown on the Supplement. 
 3.12 Copyrights, Patents, Trademarks and
Licenses. 
 (a) Borrower owns or is licensed or otherwise has the right to use all of the patents, trademarks, service marks,
trade names, copyrights, contractual franchises, authorizations and other similar rights that are reasonably necessary for the operation of its business, without conflict with the rights of any other Person. 
 (b) To Borrower’s knowledge, no slogan or other advertising device, product, process, method, substance, part or other material now employed, or now
contemplated to be employed, by Borrower infringes upon any rights held by any other Person. 
 (c) No claim or litigation regarding any of
the foregoing is pending or, to Borrower’s knowledge, threatened, and no patent, invention, device, application, principle or any statute, law, rule, regulation, standard or code is pending or proposed which, in either case, could reasonably be
expected to have a Material Adverse Effect. 
 3.13 Survival. The representations and warranties of Borrower as set forth in
this Agreement survive the execution and delivery of this Agreement. 
 ARTICLE 4—CONDITIONS PRECEDENT 
 4.1 Conditions to First Loan. The obligation of Lender to make its first Loan hereunder is, in addition to the conditions precedent specified in
Section 4.2 and in any Supplement, subject to the fulfillment of the following conditions and to the receipt by Lender of the documents described below, duly executed and in form and substance satisfactory to Lender and its counsel: 

(a) Resolutions. A certified copy of the resolutions of the Board of Directors of Borrower authorizing the execution, delivery and performance
by Borrower of the Loan Documents. 
 (b) Incumbency and Signatures. A certificate of the secretary of Borrower certifying the names
of the officer or officers of Borrower authorized to sign the Loan Documents, together with a sample of the true signature of each such officer. 
 (c) Legal Opinion. The opinion of legal counsel for Borrower as to such matters as Lender may reasonably request, including the matters covered by Sections 3.1, 3.2, 3.4 and 3.5 hereof. 
 (d) Articles and By-Laws. Certified copies of the Articles or Certificate of Incorporation and By-Laws of Borrower, as amended through the Closing
Date. 
 (e) This Agreement. A counterpart of this Agreement and an initial Supplement, with all schedules completed and attached
thereto, and disclosing such information as is acceptable to Lender. 
 (f) Financing Statements. Filing copies (or other evidence of
filing satisfactory to Lender and its counsel) of such UCC financing statements, collateral assignments, account control agreements, and termination statements, with respect to the Collateral as Lender shall request. 
 (g) Insurance Certificates. Insurance certificates showing Lender as loss payee and as additional insured. 
 (h) Lien Searches. UCC lien, judgment, bankruptcy and tax lien searches of Borrower from such jurisdictions or offices as Lender may reasonably
request, all as of a date reasonably satisfactory to Lender and its counsel. 
 (i) Good Standing Certificate. A Certificate of status
or good standing of Borrower as of a date acceptable to Lender from the jurisdiction of Borrower’s organization and any foreign jurisdictions where Borrower is qualified to do business. 
 (j) Warrant(s). One or more warrants issued by Borrower to Lender (or its designee) exercisable for such number, type and class of shares of
Borrower’s capital stock, and for an initial exercise price as is specified in the Supplement. 
 (k) Other Documents. Such other
documents and instruments as Lender may reasonably request to effectuate the intents and purposes of this Agreement. 
 4.2 Conditions to
All Loans. The obligation of Lender to make its initial Loan and each subsequent Loan is subject to the following further conditions precedent that: 
 (a) No Default. No Default or Event of Default has occurred and is continuing or will result from the making of any such Loan, and the representations and warranties of Borrower contained in Article 3 of this
Agreement and Part 3 of the Supplement are true and correct as of the Borrowing Date of such Loan. 
  

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 (b) No Material Adverse Change. No event has occurred that has had or could reasonably be expected
to have a Material Adverse Change. 
 (c) Borrowing Request. Borrower shall have delivered to Lender a Borrowing Request for such
Loan. 
 (d) Note. Borrower shall have delivered an executed Note evidencing such Loan, substantially in the form of Exhibit
“A” attached to the Supplement. 
 (e) Supplemental Lien Filings. Borrower shall have executed and delivered such
amendments or supplements to this Agreement and additional Security Documents, financing statements and third party waivers as Lender may reasonably request in connection with the proposed Loan, in order to create, protect or perfect or to maintain
the perfection of Lender’s Liens on the Collateral. 
 (f) VCOC Limitation. Lender shall not be obligated to make any Loan under
its Commitment if at the time of or after giving effect to the proposed Loan Lender would no longer qualify as: (A) a “venture capital operating company” under U.S. Department of Labor Regulations Section 2510.3-101(d), Title 29
of the Code of Federal Regulations, as amended; and (B) a “business development company” under the provisions of federal Investment Company Act of 1940, as amended; and (C) a “regulated investment company” under the
provisions of the Internal Revenue Code of 1986, as amended. 
 (g) Financial Projections. Borrower shall have delivered to Lender
Borrower’s business plan and/or financial projections or forecasts as most recently approved by Borrower’s Board of Directors. 
 ARTICLE
5—AFFIRMATIVE COVENANTS 
 During the term of this Agreement and until its performance of all Obligations, Borrower will: 

5.1 Notice to Lender. Promptly give written notice to Lender of: 
 (a) Any litigation or administrative or regulatory proceeding affecting Borrower where the amount claimed against Borrower is at the Threshold Amount or more, or where the granting of the relief requested could have a
Material Adverse Effect; or of the acquisition by Borrower of any commercial tort claim, including brief details of such claim and such other information as Lender may reasonably request to enable Lender to better perfect its Lien in such commercial
tort claim as Collateral. 
 (b) Any substantial dispute which may exist between Borrower or any governmental or regulatory authority.

 (c) The occurrence of any Default or any Event of Default. 
 (d) Any change in the location of any of Borrower’s places of business or Collateral at least thirty (30) days in advance of such change, or of the establishment of any new, or the discontinuance of any
existing, place of business. 
 (e) Any dispute or default by Borrower or any other party under any joint venture, partnering, distribution,
cross-licensing, strategic alliance, collaborative research or manufacturing, license or similar agreement which could reasonably be expected to have a Material Adverse Effect. 
 (f) Any other matter which has resulted or might reasonably result in a Material Adverse Change. 
 5.2 Financial Statements. Deliver to Lender or cause to be delivered to Lender, in form and detail satisfactory to Lender the following financial
and other information, which Borrower warrants shall be accurate and complete in all material respects: 
 (a) Monthly Financial
Statements. As soon as available but no later than thirty (30) days after the end of each month, Borrower’s balance sheet as of the end of such period, and Borrower’s income statement for such period and for that portion of
Borrower’s financial reporting year ending with such period, prepared in accordance with GAAP and attested by a responsible financial officer of Borrower as being complete and correct and fairly presenting Borrower’s financial condition
and the results of Borrower’s operations. After a Qualified Public Offering, the foregoing interim financial statements shall be delivered no later than 45 days after each fiscal quarter and for the quarter-annual fiscal period then ended.

  

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 (b) Year-End Financial Statements. As soon as available but no later than one hundred eighty
(180) days after and as of the end of each financial reporting year, a complete copy of Borrower’s audit report, which shall include balance sheet, income statement, statement of changes in equity and statement of cash flows for such year,
prepared in accordance with GAAP and certified by an independent certified public accountant selected by Borrower and satisfactory to Lender (the “Accountant”). The Accountant’s certification shall not be qualified or limited due to a
restricted or limited examination by the Accountant of any material portion of Borrower’s records or otherwise. 
 (c) Compliance
Certificates. Simultaneously with the delivery of each set of financial statements referred to in paragraphs (a) and (b) above, a certificate of the chief financial officer of Borrower substantially in the form of Exhibit
“C” to the Supplement (i) setting forth in reasonable detail any calculations required to establish whether Borrower is in compliance with any financial covenants or tests set forth in the Supplement, and (ii) stating whether
any Default or Event of Default exists on the date of such certificate, and if so, setting forth the details thereof and the action which Borrower is taking or proposes to take with respect thereto. 
 (d) Government Required Reports; Press Releases. Promptly after sending, issuing, making available, or filing, copies of all statements released
to any news media for publication, all reports, proxy statements, and financial statements that Borrower sends or makes available to its stockholders, and, not later than five (5) days after actual filing or the date such filing was first due,
all registration statements and reports that Borrower files or is required to file with the Securities and Exchange Commission, or any other governmental or regulatory authority. 
 (e) Other Information. Such other statements, lists of property and accounts, budgets, forecasts, reports, information regarding equity financings
that are consummated after the Closing Date or other information as Lender may from time to time reasonably request. 
 5.3 Managerial
Assistance from Lender. At no cost to Borrower, permit Lender to substantially participate in, and substantially influence the conduct of management of Borrower through the exercise of “management rights,” as that term is defined in 29
C.F.R. § 2510.3-101(d), including without limitation the following rights: 
 (a) Borrower agrees that (i) it will make its
officers, directors, employees and affiliates available at such times as Lender may reasonably request for Lender to consult with and advise as to the conduct of Borrower’s business, its equipment and financing plans, and its financial
condition and prospects, (ii) Lender shall have the right to inspect Borrower’s books, records, facilities and properties at reasonable times during normal business hours on reasonable advance notice, and (iii) Lender shall be
entitled to recommend prospective candidates for election or nomination for election to Borrower’s Board of Directors but Borrower shall not be bound by such recommendations, it being the intention of the parties that Lender shall be entitled
through such rights, inter alia, to furnish “significant managerial assistance”, as defined in Section 2(a)(47) of the Investment Company Act of 1940, to Borrower. 
 (b) Without limiting the generality of (a) above, if Lender reasonably believes that financial or other developments affecting Borrower have
impaired or are likely to impair Borrower’s ability to perform its obligations under this Agreement, permit Lender reasonable access to Borrower’s management and/or Board of Directors and opportunity to present Lender’s views with
respect to such developments. 
 Lender shall cooperate with Borrower to ensure that the exercise of Lender’s rights shall not disrupt the business of
Borrower. The rights enumerated above shall not be construed as giving Lender control over Borrower’s management or policies. 
 5.4
Existence. Maintain and preserve Borrower’s existence, present form of business, and all rights and privileges necessary or desirable in the normal course of its business; and keep all Borrower’s property in good working order and
condition, ordinary wear and tear excepted. 
 5.5 Insurance. Obtain and keep in force insurance in such amounts and types as is usual
in the type of business conducted by Borrower, with insurance carriers having a policyholder rating of not less than “A” and financial category rating of Class VII in “Best’s Insurance Guide,” unless otherwise approved by
Lender. Such insurance policies must be in form and substance satisfactory to Lender, and shall list Lender as an additional insured or loss payee, as applicable, on endorsement(s) in form reasonably acceptable to Lender. Borrower shall furnish to
Lender such endorsements, and upon Lender’s request, copies of any or all such policies. 
  

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 5.6 Accounting Records. Maintain adequate books, accounts and records, and prepare all financial
statements in accordance with GAAP, and in compliance with the regulations of any governmental or regulatory authority having jurisdiction over Borrower or Borrower’s business; and permit employees or agents of Lender at such reasonable times
as Lender may request, at Borrower’s expense, to inspect Borrower’s properties, and to examine, and make copies and memoranda of Borrower’s books, accounts and records. 
 5.7 Compliance With Laws. Comply with all laws (including Environmental Laws), rules, regulations applicable to, and all orders and directives of
any governmental or regulatory authority having jurisdiction over, Borrower or Borrower’s business, and with all material agreements to which Borrower is a party, except where the failure to so comply would not have a Material Adverse Effect.

 5.8 Taxes and Other Liabilities. Pay all Borrower’s Indebtedness when due; pay all taxes and other governmental or regulatory
assessments before delinquency or before any penalty attaches thereto, except as may be contested in good faith by the appropriate procedures and for which Borrower shall maintain appropriate reserves; and timely file all required tax returns.

 5.9 Special Collateral Covenants. 
 (a) Maintenance of Collateral; Inspection. Do all things reasonably necessary to maintain, preserve, protect and keep all Collateral in good working order and salable condition, ordinary wear and tear excepted,
deal with the Collateral in all ways as are considered good practice by owners of like property, and use the Collateral lawfully and, to the extent applicable, only as permitted by Borrower’s insurance policies. Maintain, or cause to be
maintained, complete and accurate Records relating to the Collateral. Upon reasonable prior notice at reasonable times during normal business hours, Borrower hereby authorizes Lender’s officers, employees, representatives and agents to inspect
the Collateral and to discuss the Collateral and the Records relating thereto with Borrower’s officers and employees, and, in the case of any Right to Payment, with any Person which is or may be obligated thereon. 
 (b) Financing Statements and Other Actions. Execute and deliver to Lender all financing statements, notices and other documents (including,
without limitation, any filings with the United States Patent and Trademark Office) from time to time reasonably requested by Lender to maintain a first perfected security interest in the Collateral in favor of Lender; perform such other acts, and
execute and deliver to Lender such additional conveyances, assignments, agreements and instruments, as Lender may at any time request in connection with the administration and enforcement of this Agreement or Lender’s rights, powers and
remedies hereunder. 
 (c) Liens. Not create, incur, assume or permit to exist any Lien or grant any other Person a negative pledge on
any Collateral, except Permitted Liens. 
 (d) Documents of Title. Not sign or authorize the signing of any financing statement or
other document naming Borrower as debtor or obligor, or acquiesce or cooperate in the issuance of any bill of lading, warehouse receipt or other document or instrument of title with respect to any Collateral, except those negotiated to Lender, or
those naming Lender as secured party. 
 (e) Change in Location or Name. Without at least 30 days’ prior written notice to
Lender: (a) not relocate any Collateral or Records, its chief executive office, or establish a place of business at a location other than as specified in the Supplement; and (b) not change its name, mailing address, location of Collateral,
jurisdiction of incorporation or its legal structure. 
 (f) Decals, Markings. At the request of Lender, firmly affix a decal, stencil
or other marking to designated items of Equipment, indicating thereon the security interest of Lender. 
 (g) Agreement With Real Property
Owner/Landlord. Obtain and maintain such acknowledgments, consents, waivers and agreements from the owner, lienholder, mortgagee and landlord with respect to any real property on which Equipment is located as Lender may require, all in form and
substance satisfactory to Lender. Lender hereby waives the requirement of this Section 5.9(g) with respect to Borrower’s principal place of business in St. Paul, Minnesota leased and occupied by Borrower as of the Closing Date based on
Borrower’s representation that such lease does not give the lessor an interest in the Equipment located at such place of business. 
 (h) Certain Agreements on Rights to Payment. Other than in the ordinary course of business, not make any material discount, credit, rebate or other reduction in the original amount owing on a Right to Payment or accept in
satisfaction of a Right to Payment less than the original amount thereof. 
  

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 5.10 Authorization for Automated Clearinghouse Funds Transfer. (i) Authorize Lender to
initiate debit entries to Borrower’s Primary Operating Account, specified in the Supplement attached hereto, through Automated Clearinghouse (“ACH”) transfers, in order to satisfy regularly scheduled payments of principal, interest
and Terminal Payments; (ii) provide Lender at least thirty (30) days notice of any change in Borrower’s Primary Operating Account; and (iii) grant Lender any additional authorizations necessary to begin ACH debits from a new
account which becomes the Primary Operating Account. 
 ARTICLE 6—NEGATIVE COVENANTS 
 During the term of this Agreement and until the performance of all Obligations, Borrower will not: 
 6.1 Indebtedness. Be indebted for borrowed money, the deferred purchase price of property, or leases which would be capitalized in accordance with
GAAP; or become liable as a surety, guarantor, accommodation party or otherwise for or upon the obligation of any other Person, except: 
 (a)
Indebtedness incurred for the acquisition of supplies or inventory on normal trade credit; 
 (b) Indebtedness incurred for customer trade
payable and other vendor-based operating leases; 
 (c) Indebtedness incurred pursuant to one or more transactions permitted under
Section 6.4; 
 (d) Indebtedness of Borrower under this Agreement; 
 (e) Indebtedness of Borrower under the VLL4 Loan Agreement; 
 (f) Indebtedness incurred in accordance with Section 4 of Part 2 of the Supplement; 
 (g) Indebtedness
to a commercial bank (“Bank”) under a corporate card program not to exceed Fifty Thousand Dollars ($50,000) in aggregate amount outstanding at any time; and 
 (h) Any Indebtedness approved by Lender prior to the Closing Date and set forth on Schedule 6.1. 
 6.2 Liens. Create, incur, assume or permit to exist any Lien, or grant any other Person a negative pledge, on any of Borrower’s property,
except Permitted Liens. Without limiting the generality of the foregoing, and as a material inducement to the Lenders’ making of the Commitment and entering into the Loan Documents, Borrower agrees that it shall not assign, mortgage, pledge,
grant a security interest in, or encumber any of Borrower’s Intellectual Property, or enter into any agreement, document, instrument or other arrangement (except with or in favor of Lenders) with any Person which directly or indirectly
prohibits or has the effect of prohibiting Borrower from assigning, mortgaging, pledging, granting a security interest in or upon, or encumbering any of Borrower’s Intellectual Property, except as is otherwise permitted in Section 6.5(i)
of this Agreement and clause (h) of the definition of “Permitted Lien” herein. 
 6.3 Dividends. Except after a
Qualified Public Offering, pay any dividends or purchase, redeem or otherwise acquire or make any other distribution with respect to any of Borrower’s capital stock, except (a) dividends or other distributions solely of capital stock of
Borrower, and (b) so long as no Event of Default has occurred and is continuing, repurchases of stock from employees upon termination of employment under reverse vesting or similar repurchase plans not to exceed $100,000 in any calendar year.

 6.4 Changes/Mergers. Liquidate or dissolve; or enter into any consolidation, merger or other combination in which the stockholders
of the Borrower immediately prior to the first such transaction own less than 50% of the voting stock of the Borrower immediately after giving effect to such transaction or related series of such transactions, except that Borrower may consolidate or
merge so long as: (A) the entity that results from such merger or consolidation (the “Surviving Entity”) shall have executed and delivered to Lender an agreement in form and substance reasonably satisfactory to Lender, containing an
assumption by the Surviving Entity of the due and punctual payment and performance of all Obligations and performance and observance of each covenant and condition of Borrower in the Loan Documents; (B) all such obligations of the Surviving
Entity to Lender shall be guaranteed by any entity that directly or indirectly owns or controls more than 50% of the voting stock of the Surviving Entity; (C) immediately after giving effect to such merger or consolidation, no Event of Default
or, event which with the lapse of time or giving of notice or both, would result in an Event of Default shall have occurred and be continuing; and (D) the 

  

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credit risk to Lender, in its sole discretion, of the Surviving Entity shall not be increased. In determining whether the proposed merger or consolidation
would result in an increased credit risk, Lender may consider, among other things, changes in Borrower’s management team, employee base, access to equity markets, venture capital support, financial position and/or disposition of intellectual
property rights which may reasonably be anticipated as a result of the transaction. 
 6.5 Sales of Assets. Sell, transfer, lease,
license or otherwise dispose of (a “Transfer”) any of Borrower’s assets except (i) exclusive and non-exclusive licenses of Intellectual Property in the ordinary course of business consistent with industry practice;
(ii) Transfers of worn-out, obsolete or surplus property (each as determined by the Borrower in its reasonable judgment); (iii) Transfers of Inventory; (iv) Transfers constituting Permitted Liens; (v) Transfers permitted in
Section 6.6 hereunder; and (vi) Transfers of assets (other than Intellectual Property) for fair consideration and in the ordinary course of its business. 
 6.6 Loans/Investments. Make or suffer to exist any loans, guaranties, advances, or investments, except: 
 (a) Accounts receivable in the ordinary course of Borrower’s business; 
 (b) Investments in domestic certificates of deposit
issued by, and other domestic investments with, financial institutions organized under the laws of the United States or a state thereof, having at least One Hundred Million Dollars ($100,000,000) in capital and a rating of at least “investment
grade” or “A” by Moody’s or any successor rating agency; 
 (c) Investments in marketable obligations of the United
States of America and in open market commercial paper given the highest credit rating by a national credit agency and maturing not more than one year from the creation thereof; 
 (d) Temporary advances to cover incidental expenses to be incurred in the ordinary course of business; 
 (e) Investments in joint ventures, strategic alliances, licensing and similar arrangements customary in Borrower’s industry and which do not require
Borrower to assume or otherwise become liable for the obligations of any third party not directly related to or arising out of such arrangement or, without the prior written consent of Lender, require Borrower to transfer ownership of non-cash
assets to such joint venture or other entity; and 
 (f) Investments in wholly-owned subsidiaries of the Borrower. 
 6.7 Transactions With Related Persons. Directly or indirectly enter into any transaction with or for the benefit of a Related Person on terms more
favorable to the Related Person than would have been obtainable in an “arms’ length” dealing. 
 6.8 Other Business.
Engage in any material line of business other than the business Borrower conducts as of the Closing Date. 
 6.9 Financial Covenants.
Fail to comply with any financial covenants or tests set forth in the Supplement. 
 6.10 Compliance. Become an “investment
company” or controlled by an “investment company,” within the meaning of the Investment Company Act of 1940, or become principally engaged in, or undertake as one of its important activities, the business of extending credit for the
purpose of purchasing or carrying margin stock, or use the proceeds of any Loan for such purpose. Fail to meet the minimum funding requirements of ERISA, permit a Reportable Event or Prohibited Transaction, as defined in ERISA, to occur, fail to
comply with the Federal Fair Labor Standards Act or violate any law or regulation, which violation could have a Material Adverse Effect or a material adverse effect on the Collateral or the priority of Lender’s Lien on the Collateral, or permit
any of its subsidiaries to do any of the foregoing. 
 6.11 Other Deposit and Securities Accounts. Maintain any deposit accounts or
accounts holding securities owned by Borrower except (i) Deposit Accounts and investment/securities accounts as set forth in the Supplement, and (ii) other Deposit Accounts and securities/investment accounts, in each case, with respect to
which Borrower and Lender shall have taken such action as Lender reasonably deems necessary to obtain a perfected first security interest therein. Notwithstanding anything contained herein to the contrary, including the Borrower’s grant of a
security interest in Section 2.10(a), Lender agrees that, in the event the Lender instructs any depositary bank to (i) deliver funds to the Lender or (ii) not to permit the Borrower to withdraw funds from any Deposit Account, the
Borrower may withdraw, for a period not to exceed 30 days commencing on the date 

  

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Lender delivers such instructions, an amount in the Deposit Accounts not to exceed $250,000 for the purpose of meeting Borrower’s then current payroll
obligations or, with Lender’s consent, other outstanding obligations of Borrower, and that any such withdrawal shall be free and clear of any interest of the Lender in such funds. The Lender shall provide instruction to such depositary bank in
order to permit the Borrower to make such withdrawal. 
 ARTICLE 7—EVENTS OF DEFAULT 
 7.1 Events of Default; Acceleration. Upon the occurrence and during the continuation of any Default, the obligation of Lender to make any
additional Loan shall be suspended. The occurrence of any of the following (each, an “Event of Default”) shall terminate any obligation of Lender to make any additional Loan; and shall, at the option of Lender (1) make all sums of
Basic Interest and principal, all Terminal Payments, and any Obligations and other amounts owing under any Loan Documents immediately due and payable without notice of default, presentment or demand for payment, protest or notice of nonpayment or
dishonor or any other notices or demands, and (2) give Lender the right to exercise any other right or remedy provided by contract or applicable law: 
 (a) Borrower shall fail to pay any principal, interest or Terminal Payment under this Agreement or any Note, or fail to pay any fees or other charges when due under any Loan Document, and such failure continues for
three (3) Business Days or more after the same first becomes due; or an Event of Default as defined in any other Loan Document shall have occurred. 
 (b) Any representation or warranty made, or financial statement, certificate or other document provided, by Borrower under any Loan Document shall prove to have been false or misleading in any material respect when
made or deemed made herein. 
 (c) Borrower shall fail to pay its debts generally as they become due or shall commence any Insolvency
Proceeding with respect to itself; an involuntary Insolvency Proceeding shall be filed against Borrower, or a custodian, receiver, trustee, assignee for the benefit of creditors, or other similar official, shall be appointed to take possession,
custody or control of the properties of Borrower, and such involuntary Insolvency Proceeding, petition or appointment is acquiesced to by Borrower or is not dismissed within sixty (60) days; or the dissolution or termination of the business of
Borrower; or Borrower shall take any corporate action for the purpose of effecting, approving, or consenting to any of the foregoing. 
 (d)
Borrower shall be in default beyond any applicable period of grace or cure under any other agreement involving the borrowing of money, the purchase of property, the advance of credit or any other monetary liability of any kind to Lender or to any
Person which results in the acceleration of payment of such obligation in an amount in excess of the Threshold Amount. 
 (e) Any
governmental or regulatory authority shall take any judicial or administrative action, or any defined benefit pension plan maintained by Borrower shall have any unfunded liabilities, any of which, in the reasonable judgment of Lender, might have a
Material Adverse Effect. 
 (f) Except as permitted in Section 6.4, any sale, transfer or other disposition of all or a substantial or
material part of the assets of Borrower, including without limitation to any trust or similar entity, shall occur. 
 (g) Any judgment(s)
singly or in the aggregate in excess of the Threshold Amount shall be entered against Borrower which remain unsatisfied, unvacated or unstayed pending appeal for thirty (30) or more days after entry thereof. 
 (h) At any time prior to the initial sale of Borrower’s equity securities to the public pursuant to a registration statement filed under the
Securities Act of 1933, as amended, any Person or two or more Persons (other than any “Excluded Person” as defined below) acting in concert shall have acquired (in a single transaction or series of related transactions occurring within a
six-month period) beneficial ownership (within the meaning of Rule 13d-3 of the Securities and Exchange Commission) of outstanding shares of voting stock of Borrower representing fifty percent (50%) or more of the voting power of all shares of
Borrower’s voting stock that are outstanding immediately after such acquisition. As used in this paragraph (h), “Excluded Person” means: (i) any Person who is a stockholder of Borrower as of the Closing Date; (ii) a venture
capital firm or similar investment fund or institution; (iii) any Strategic Partner of Borrower, or (iv) an affiliate of any Person described in clause (i), (ii) or (iii). For purposes of this Section 7.1(h), “Strategic
Partner” means any Person who either prior to first acquiring equity securities of Borrower has an existing contractual relationship with Borrower for the 

  

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joint development or sharing of, or similar arrangement relating to, Borrower’s technology or products, or enters into such a contractual relationship
at the time of acquiring Borrower’s securities. 
 (i) Borrower shall fail to perform or observe any covenant contained in Article 6 of
this Agreement. 
 (j) Borrower shall fail to perform or observe any covenant contained in Section 5.9 of this Agreement. 
 (k) Borrower shall fail to perform or observe any covenant contained in this Agreement or any other Loan Document (other than a covenant which is dealt
with specifically elsewhere in this Article 7) and, if capable of being cured, the breach of such covenant is not cured within 30 days after the sooner to occur of Borrower’s receipt of notice of such breach from Lender or the date on which
such breach first becomes known to any officer of Borrower; provided, however that if such breach is not capable of being cured within such 30-day period and Borrower timely notifies Lender of such fact and Borrower diligently pursues
such cure, then the cure period shall be extended to the date requested in Borrower’s notice but in no event more than 90 days from the initial breach; provided, further, that such additional 60-day opportunity to cure shall not
apply in the case of any failure to perform or observe any covenant which has been the subject of a prior failure within the preceding 180 days or which is a willful and knowing breach by Borrower. 
 7.2 Remedies Upon Default. Upon the occurrence and during the continuance of an Event of Default, Lender shall be entitled to, at
its option, exercise any or all of the rights and remedies available to a secured party under the UCC or any other applicable law, and exercise any or all of its rights and remedies provided for in this Agreement and in any other Loan Document. The
obligations of Borrower under this Agreement shall continue to be effective or be reinstated, as the case may be, if at any time any payment of any Obligations is rescinded or must otherwise be returned by Lender upon, on account of, or in
connection with, the insolvency, bankruptcy or reorganization of Borrower or otherwise, all as though such payment had not been made. 
 7.3 Sale of Collateral. Upon the occurrence and during the continuance of an Event of Default, Lender may sell all or any part of the Collateral, at public or private sales, to itself, a wholesaler, retailer or
investor, for cash, upon credit or for future delivery, and at such price or prices as Lender may deem commercially reasonable. To the extent permitted by law, Borrower hereby specifically waives all rights of redemption and any rights of stay or
appraisal which it has or may have under any applicable law in effect from time to time. Any such public or private sales shall be held at such times and at such place(s) as Lender may determine. In case of the sale of all or any part of the
Collateral on credit or for future delivery, the Collateral so sold may be retained by Lender until the selling price is paid by the purchaser, but Lender shall not incur any liability in case of the failure of such purchaser to pay for the
Collateral and, in case of any such failure, such Collateral may be resold. Lender may, instead of exercising its power of sale, proceed to enforce its security interest in the Collateral by seeking a judgment or decree of a court of competent
jurisdiction. Without limiting the generality of the foregoing, if an Event of Default is in effect, 
 (1) Subject to the rights of any third
parties, Lender may license, or sublicense, whether general, special or otherwise, and whether on an exclusive or non-exclusive basis, any Copyrights, Patents or Trademarks included in the Collateral throughout the world for such term or terms, on
such conditions and in such manner as Lender shall in its sole discretion determine; 
 (2) Lender may (without assuming any obligations or
liability thereunder), at any time and from time to time, enforce (and shall have the exclusive right to enforce) against any licensee or sublicensee all rights and remedies of Borrower in, to and under any Copyright Licenses, Patent Licenses or
Trademark Licenses and take or refrain from taking any action under any thereof, and Borrower hereby releases Lender from, and agrees to hold Lender free and harmless from and against any claims arising out of, any lawful action so taken or omitted
to be taken with respect thereto other than claims arising out of Lender’s gross negligence or willful misconduct; and 
 (3) Upon
request by Lender, Borrower will execute and deliver to Lender a power of attorney, in form and substance reasonably satisfactory to Lender for the implementation of any lease, assignment, license, sublicense, grant of option, sale or other
disposition of a Copyright, Patent or Trademark. In the event of any such disposition pursuant to this clause 3, Borrower shall supply its know-how and expertise relating to the products or services made or rendered in connection with
Patents, the manufacture and sale of the products bearing Trademarks, and its customer lists and other records relating to such Copyrights, Patents or Trademarks and to the distribution of said products, to Lender. 
  

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 7.4 Borrower’s Obligations Upon Default. Upon the request of Lender after the
occurrence and during the continuance of an Event of Default, Borrower will: 
 (a) Assemble and make available to Lender the
Collateral at such place(s) as Lender shall reasonably designate, segregating all Collateral so that each item is capable of identification; and 
 (b) Subject to the rights of any lessor, permit Lender, by Lender’s officers, employees, agents and representatives, to enter any premises where any Collateral is located, to take possession of the Collateral, to complete the
processing, manufacture or repair of any Collateral, and to remove the Collateral, or to conduct any public or private sale of the Collateral, all without any liability of Lender for rent or other compensation for the use of Borrower’s
premises. 
 ARTICLE 8—SPECIAL COLLATERAL PROVISIONS 
 8.1 Compromise and Collection. Borrower and Lender recognize that setoffs, counterclaims, defenses and other claims may be asserted by obligors with respect to certain of the Rights to Payment; that
certain of the Rights to Payment may be or become uncollectible in whole or in part; and that the expense and probability of success of litigating a disputed Right to Payment may exceed the amount that reasonably may be expected to be recovered with
respect to such Right to Payment. Borrower hereby authorizes Lender, after and during the continuance of an Event of Default, to compromise with the obligor, accept in full payment of any Right to Payment such amount as Lender shall negotiate with
the obligor, or abandon any Right to Payment. Any such action by Lender shall be considered commercially reasonable so long as Lender acts in good faith based on information known to it at the time it takes any such action. 
 8.2 Performance of Borrower’s Obligations. Without having any obligation to do so, upon reasonable prior notice to Borrower,
Lender may perform or pay any obligation which Borrower has agreed to perform or pay under this Agreement, including, without limitation, the payment or discharge of taxes or Liens levied or placed on or threatened against the Collateral. In so
performing or paying, Lender shall determine the action to be taken and the amount necessary to discharge such obligations. Borrower shall reimburse Lender on demand for any amounts paid by Lender pursuant to this Section, which amounts shall
constitute Obligations secured by the Collateral and shall bear interest from the date of demand at the Default Rate. 
 8.3 Power of
Attorney. For the purpose of protecting and preserving the Collateral and Lender’s rights under this Agreement, Borrower hereby irrevocably appoints Lender, with full power of substitution, as its attorney-in-fact with full
power and authority, after the occurrence and during the continuance of an Event of Default, to do any act which Borrower is obligated to do hereunder; to exercise such rights with respect to the Collateral as Borrower might exercise; to use such
Inventory, Equipment, Fixtures or other property as Borrower might use; to enter Borrower’s premises; to give notice of Lender’s security interest in, and to collect the Collateral; and before or after Default, to execute and file in
Borrower’s name any financing statements, amendments and continuation statements necessary or desirable to perfect or continue the perfection of Lender’s security interests in the Collateral. Borrower hereby ratifies all that Lender shall
lawfully do or cause to be done by virtue of this appointment. 
 8.4 Authorization for Lender to Take Certain Action.
The power of attorney created in Section 8.3 is a power coupled with an interest and shall be irrevocable. The powers conferred on Lender hereunder are solely to protect its interests in the Collateral and shall not impose any duty upon Lender
to exercise such powers. Lender shall be accountable only for amounts that it actually receives as a result of the exercise of such powers and in no event shall Lender or any of its directors, officers, employees, agents or representatives be
responsible to Borrower for any act or failure to act, except for gross negligence or willful misconduct. After the occurrence and during the continuance of an Event of Default, Lender may exercise this power of attorney without notice to or assent
of Borrower, in the name of Borrower, or in Lender’s own name, from time to time in Lender’s sole discretion and at Borrower’s expense. To further carry out the terms of this Agreement, after the occurrence and during the continuance
of an Event of Default, Lender may: 
 (a) Execute any statements or documents or take possession of, and endorse and collect and
receive delivery or payment of, any checks, drafts, notes, acceptances or other instruments and documents constituting Collateral, or constituting the payment of amounts due and to become due or any performance to be rendered with respect to the
Collateral. 
  

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 (b) Sign and endorse any invoices, freight or express bills, bills of lading, storage or warehouse
receipts; drafts, certificates and statements under any commercial or standby letter of credit relating to Collateral; assignments, verifications and notices in connection with Accounts; or any other documents relating to the Collateral, including
without limitation the Records. 
 (c) Use or operate Collateral or any other property of Borrower for the purpose of preserving or
liquidating Collateral. 
 (d) File any claim or take any other action or proceeding in any court of law or equity or as otherwise
deemed appropriate by Lender for the purpose of collecting any and all monies due or securing any performance to be rendered with respect to the Collateral. 
 (e) Commence, prosecute or defend any suits, actions or proceedings or as otherwise deemed appropriate by Lender for the purpose of protecting or collecting the Collateral. In furtherance of this right, upon
the occurrence and during the continuance of an Event of Default, Lender may apply for the appointment of a receiver or similar official to operate Borrower’s business. 
 (f) Prepare, adjust, execute, deliver and receive payment under insurance claims, and collect and receive payment of and endorse any instrument in
payment of loss or returned premiums or any other insurance refund or return, and apply such amounts at Lender’s sole discretion, toward repayment of the Obligations or replacement of the Collateral. 
 8.5 Application of Proceeds. Any Proceeds and other monies or property received by Lender pursuant to the terms of this Agreement or any Loan
Document may be applied by Lender first to the payment of expenses of collection, including without limitation reasonable attorneys’ fees, and then to the payment of the Obligations in such order of application as Lender may elect. 

8.6 Deficiency. If the Proceeds of any disposition of the Collateral are insufficient to cover all costs and expenses of such sale and the
payment in full of all the Obligations, plus all other sums required to be expended or distributed by Lender, then Borrower shall be liable for any such deficiency. 
 8.7 Lender Transfer. Upon the transfer of all or any part of the Obligations, Lender may transfer all or part of the Collateral and shall be fully discharged thereafter from all liability and responsibility
with respect to such Collateral so transferred, and the transferee shall be vested with all the rights and powers of Lender hereunder with respect to such Collateral so transferred, but with respect to any Collateral not so transferred, Lender shall
retain all rights and powers hereby given. 
 8.8 Lender’s Duties. 
 (a) Lender shall use reasonable care in the custody and preservation of any Collateral in its possession. Without limitation on other conduct which
may be considered the exercise of reasonable care, Lender shall be deemed to have exercised reasonable care in the custody and preservation of such Collateral if such Collateral is accorded treatment substantially equal to that which Lender accords
its own property, it being understood that Lender shall not have any responsibility for ascertaining or taking action with respect to calls, conversions, exchanges, maturities, declining value, tenders or other matters relative to any Collateral,
regardless of whether Lender has or is deemed to have knowledge of such matters; or taking any necessary steps to preserve any rights against any Person with respect to any Collateral. Under no circumstances shall Lender be responsible for any
injury or loss to the Collateral, or any part thereof, arising from any cause beyond the reasonable control of Lender. 
 (b) Lender
may at any time deliver the Collateral or any part thereof to Borrower and the receipt of Borrower shall be a complete and full acquittance for the Collateral so delivered, and Lender shall thereafter be discharged from any liability or
responsibility therefor. 
 (c) Neither Lender, nor any of its directors, officers, employees, agents, attorneys or any other person
affiliated with or representing Lender shall be liable for any claims, demands, losses or damages, of any kind whatsoever, made, claimed, incurred or suffered by Borrower or any other party through the ordinary negligence of Lender, or any of its
directors, officers, employees, agents, attorneys or any other person affiliated with or representing Lender. 
 8.9 Termination of
Security Interests. Upon the payment in full of the Obligations and satisfaction of all Borrower’s obligations under this Agreement and the other Loan Documents, and if Lender has no further obligations under its Commitment, the security
interest granted hereby shall terminate and all rights to the 

  

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Collateral shall revert to Borrower. Upon any such termination, the Lender shall, at Borrower’s expense, execute and deliver to Borrower such documents
as Borrower shall reasonably request to evidence such termination. 
 ARTICLE 9—GENERAL PROVISIONS 
 9.1 Notices. Any notice given by any party under any Loan Document shall be in writing and personally delivered, sent by overnight courier, or
United States mail, postage prepaid, or sent by facsimile, or other authenticated message, charges prepaid, to the other party’s or parties’ addresses shown on the Supplement. Each party may change the address or facsimile number to which
notices, requests and other communications are to be sent by giving written notice of such change to each other party. Notice given by hand delivery shall be deemed received on the date delivered; if sent by overnight courier, on the next Business
Day after delivery to the courier service; if by first class mail, on the third Business Day after deposit in the U.S. Mail; and if by facsimile, on the date of transmission. 
 9.2 Binding Effect. The Loan Documents shall be binding upon and inure to the benefit of Borrower and Lender and their respective successors and
assigns; provided, however, that Borrower may not assign or transfer Borrower’s rights or obligations under any Loan Document. Lender reserves the right to sell, assign, transfer, negotiate or grant participations in all or any part of, or any
interest in, Lender’s rights and obligations under the Loan Documents. In connection with any of the foregoing, Lender may disclose all documents and information which Lender now or hereafter may have relating to the Loans, Borrower, or its
business; provided that any person who receives such information shall have agreed in writing in advance to maintain the confidentiality of such information on terms reasonably acceptable to Borrower. It is the intention of the parties that, as a
“venture capital operating company,” each of Venture Lending & Leasing IV, LLC (the parent and sole owner of VLL4), and Venture Lending & Leasing V, LLC (the parent and sole owner of VLL5) (together, “LLC”)
shall have the benefit of, and the power to independently exercise, those “management rights” provided to Lender in Section 5.3. To that end, the references to Lender in Sections 4.2(f), 5.1, 5.2, 5.3 and 5.9(a) hereof shall include
LLC, and LLC shall have the right to exercise the advisory, inspection, information and other rights given to lender under those Sections independently of Lender. No amendment or modification of this Agreement shall alter or diminish LLC’s
rights under the preceding sentence without the consent of LLC. 
 9.3 No Waiver. Any waiver, consent or approval by Lender of any
Event of Default or breach of any provision, condition, or covenant of any Loan Document must be in writing and shall be effective only to the extent set forth in writing. No waiver of any breach or default shall be deemed a waiver of any later
breach or default of the same or any other provision of any Loan Document. No failure or delay on the part of Lender in exercising any power, right, or privilege under any Loan Document shall operate as a waiver thereof, and no single or partial
exercise of any such power, right, or privilege shall preclude any further exercise thereof or the exercise of any other power, right or privilege. Lender has the right at its sole option to continue to accept interest and/or principal payments due
under the Loan Documents after default, and such acceptance shall not constitute a waiver of said default or an extension of the Maturity Date unless Lender agrees otherwise in writing. 
 9.4 Rights Cumulative. All rights and remedies existing under the Loan Documents are cumulative to, and not exclusive of, any other rights or
remedies available under contract or applicable law. 
 9.5 Unenforceable Provisions. Any provision of any Loan Document executed by
Borrower which is prohibited or unenforceable in any jurisdiction, shall be so only as to such jurisdiction and only to the extent of such prohibition or unenforceability, but all the remaining provisions of any such Loan Document shall remain valid
and enforceable. 
 9.6 Accounting Terms. Except as otherwise provided in this Agreement, accounting terms and financial covenants and
information shall be determined and prepared in accordance with GAAP. 
 9.7 Indemnification; Exculpation. Borrower shall pay and
protect, defend and indemnify Lender and Lender’s employees, officers, directors, shareholders, affiliates, correspondents, agents and representatives (other than Lender, collectively “Agents”) against, and hold Lender and each such
Agent harmless from, all claims, actions, proceedings, liabilities, damages, losses, expenses (including, without limitation, attorneys’ fees and costs) and other amounts incurred by Lender and each such Agent, arising from (i) the matters
contemplated by this Agreement or any other Loan Documents, (ii) any dispute between Borrower and a third party, or (iii) any contention that Borrower has failed to comply with any law, rule, regulation, 

  

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order or directive applicable to Borrower’s business; provided, however, that this indemnification shall not apply to any of the foregoing
incurred solely as the result of Lender’s or any Agent’s gross negligence or willful misconduct. This indemnification shall survive the payment and satisfaction of all of Borrower’s Obligations to Lender. 
 9.8 Reimbursement. Borrower shall reimburse Lender for all costs and expenses, including without limitation reasonable attorneys’ fees and
disbursements expended or incurred by Lender in any arbitration, mediation, judicial reference, legal action or otherwise in connection with (a) the preparation and negotiation of the Loan Documents, (b) the amendment and enforcement of
the Loan Documents, including without limitation during any workout, attempted workout, and/or in connection with the rendering of legal advice as to Lender’s rights, remedies and obligations under the Loan Documents, (c) collecting any
sum which becomes due Lender under any Loan Document, (d) any proceeding for declaratory relief, any counterclaim to any proceeding, or any appeal, or (e) the protection, preservation or enforcement of any rights of Lender. For the
purposes of this section, attorneys’ fees shall include, without limitation, fees incurred in connection with the following: (1) contempt proceedings; (2) discovery; (3) any motion, proceeding or other activity of any kind in
connection with an Insolvency Proceeding; (4) garnishment, levy, and debtor and third party examinations; and (5) postjudgment motions and proceedings of any kind, including without limitation any activity taken to collect or enforce any
judgment. All of the foregoing costs and expenses shall be payable upon demand by Lender, and if not paid within forty-five (45) days of presentation of invoices shall bear interest at the highest applicable Default Rate. 
 9.9 Execution in Counterparts. This Agreement may be executed in any number of counterparts which, when taken together, shall constitute but one
agreement. 
 9.10 Entire Agreement. The Loan Documents are intended by the parties as the final expression of their agreement and
therefore contain the entire agreement between the parties and supersede all prior understandings or agreements concerning the subject matter hereof. This Agreement may be amended only in a writing signed by Borrower and Lender. 
 9.11 Governing Law and Jurisdiction. 
 (a) THIS AGREEMENT AND THE LOAN DOCUMENTS SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE INTERNAL LAWS OF THE STATE OF CALIFORNIA. 
 (b) ANY LEGAL ACTION OR PROCEEDING WITH RESPECT TO THIS AGREEMENT OR ANY OTHER LOAN DOCUMENT MAY BE BROUGHT IN THE COURTS OF THE STATE OF CALIFORNIA OR OF THE UNITED STATES FOR THE NORTHERN DISTRICT OF CALIFORNIA, AND
BY EXECUTION AND DELIVERY OF THIS AGREEMENT, EACH OF BORROWER AND LENDER CONSENTS, FOR ITSELF AND IN RESPECT OF ITS PROPERTY, TO THE NON-EXCLUSIVE JURISDICTION OF THOSE COURTS. EACH OF BORROWER AND LENDER IRREVOCABLY WAIVES ANY OBJECTION, INCLUDING
ANY OBJECTION TO THE LAYING OF VENUE OR BASED ON THE GROUNDS OF FORUM NON CONVENIENS, WHICH IT MAY NOW OR HEREAFTER HAVE TO THE BRINGING OF ANY ACTION OR PROCEEDING IN SUCH JURISDICTION IN RESPECT OF THIS AGREEMENT OR ANY DOCUMENT RELATED HERETO.
BORROWER AND LENDER EACH WAIVE PERSONAL SERVICE OF ANY SUMMONS, COMPLAINT OR OTHER PROCESS, WHICH MAY BE MADE BY ANY OTHER MEANS PERMITTED BY CALIFORNIA LAW. 
 9.12 Waiver of Jury Trial. BORROWER AND LENDER EACH WAIVES ITS RESPECTIVE RIGHTS TO A TRIAL BY JURY OF ANY CLAIM OR CAUSE OF ACTION BASED UPON OR ARISING OUT OF OR RELATED TO THIS AGREEMENT, THE OTHER LOAN
DOCUMENTS, OR THE TRANSACTIONS CONTEMPLATED HEREBY OR THEREBY, IN ANY ACTION, PROCEEDING OR OTHER LITIGATION OF ANY TYPE BROUGHT BY ANY OF THE PARTIES AGAINST ANY OTHER PARTY OR ANY PARTICIPANT OR ASSIGNEE, WHETHER WITH RESPECT TO CONTRACT CLAIMS,
TORT CLAIMS, OR OTHERWISE. BORROWER AND LENDER EACH AGREES THAT ANY SUCH CLAIM OR CAUSE OF ACTION SHALL BE TRIED BY A COURT TRIAL WITHOUT A JURY. WITHOUT LIMITING THE FOREGOING, THE PARTIES FURTHER AGREE THAT THEIR RESPECTIVE RIGHT TO A TRIAL BY
JURY IS WAIVED BY OPERATION OF THIS SECTION AS 

  

 15 

 
TO ANY ACTION, COUNTERCLAIM OR OTHER PROCEEDING WHICH SEEMS, IN WHOLE OR IN PART, TO CHALLENGE THE VALIDITY OR ENFORCEABILITY OF THIS AGREEMENT OR THE OTHER
LOAN DOCUMENTS OR ANY PROVISION HEREOF OR THEREOF. THIS WAIVER SHALL APPLY TO ANY SUBSEQUENT AMENDMENTS, RENEWALS, SUPPLEMENTS OR MODIFICATIONS TO THIS AGREEMENT AND THE OTHER LOAN DOCUMENTS. 
 ARTICLE 10—DEFINITIONS 
 The definitions
appearing in this Agreement or any Supplement shall be applicable to both the singular and plural forms of the defined terms: 
 “Account”
means any “account,” as such term is defined in the UCC, now owned or hereafter acquired by Borrower or in which Borrower now holds or hereafter acquires any interest and, in any event, shall include, without limitation, all accounts
receivable, book debts and other forms of obligations (other than forms of obligations evidenced by Chattel Paper, Documents or Instruments) now owned or hereafter received or acquired by or belonging or owing to Borrower (including, without
limitation, under any trade name, style or division thereof) whether arising out of goods sold or services rendered by Borrower or from any other transaction, whether or not the same involves the sale of goods or services by Borrower (including,
without limitation, any such obligation that may be characterized as an account or contract right under the UCC) and all of Borrower’s rights in, to and under all purchase orders or receipts now owned or hereafter acquired by it for goods or
services, and all of Borrower’s rights to any goods represented by any of the foregoing (including, without limitation, unpaid seller’s rights of rescission, replevin, reclamation and stoppage in transit and rights to returned, reclaimed
or repossessed goods), and all monies due or to become due to Borrower under all purchase orders and contracts for the sale of goods or the performance of services or both by Borrower or in connection with any other transaction (whether or not yet
earned by performance on the part of Borrower), now in existence or hereafter occurring, including, without limitation, the right to receive the proceeds of said purchase orders and contracts, and all collateral security and guarantees of any kind
given by any Person with respect to any of the foregoing. 
 “Affiliate” means any Person which directly or indirectly controls, is
controlled by, or is under common control with Borrower. “Control,” “controlled by” and “under common control with” mean direct or indirect possession of the power to direct or cause the direction of management or
policies (whether through ownership of voting securities, by contract or otherwise); provided, that control shall be conclusively presumed when any Person or affiliated group directly or indirectly owns five percent (5%) or more of the
securities having ordinary voting power for the election of directors of a corporation. 
 “Agreement” means this Loan and Security
Agreement and each Supplement thereto, as each may be amended or supplemented from time to time. 
 “Bankruptcy Code” means the Federal
Bankruptcy Reform Act of 1978 (11 U.S.C. §101, et seq.), as amended. 
 “Basic Interest” means the fixed rate of interest
payable on the outstanding balance of each Loan at the applicable Designated Rate. 
 “Borrowing Date” means the Business Day on which the
proceeds of a Loan are disbursed by Lender. 
 “Borrowing Request” means a written request from Borrower in substantially the form of
Exhibit “B” to the Supplement, requesting the funding of one or more Loans on a particular Borrowing Date. 
 “Business
Day” means any day other than a Saturday, Sunday or other day on which commercial banks in New York City or San Francisco are authorized or required by law to close. 
 “Chattel Paper” means any “chattel paper,” as such term is defined in the UCC, now owned or hereafter acquired by Borrower or in which Borrower now holds or hereafter acquires any interest.

 “Closing Date” means the date of this Agreement. 
 “Collateral” means all of Borrower’s right, title and interest in and to the following property, whether now owned or hereafter acquired and wherever located: (a) all Receivables; (b) all Equipment;
(c) all Fixtures; (d) all General Intangibles (subject to the exclusion described below with respect to Intellectual Property); (e) all Inventory; (f) all Investment Property; (g) all Deposit Accounts; (h) all other
Goods and personal property of Borrower, whether tangible or intangible and whether now or hereafter owned or existing, leased, consigned by or to, or acquired by, Borrower and wherever located; (i) all 

  

 16 

 
Records; and (j) all Proceeds of each of the foregoing and all accessions to, substitutions and replacements for, and rents, profits and products of
each of the foregoing; provided, however, that the foregoing “Collateral” shall not include Intellectual Property. 
 “Commitment” means the obligation of Lender to make Loans to Borrower up to the aggregate principal amount set forth in the Supplement. 
 “Copyright License” means any written agreement granting any right to use any Copyright or Copyright registration now owned or hereafter acquired by Borrower or in which Borrower now holds or hereafter acquires any
interest. 
 “Copyrights” means all of the following now owned or hereafter acquired by Borrower or in which Borrower now holds or hereafter
acquires any interest: (i) all copyrights, whether registered or unregistered, held pursuant to the laws of the United States, any State thereof or of any other country; (ii) all registrations, applications and recordings in the United
States Copyright Office or in any similar office or agency of the United States, any State thereof or any other country; (iii) all continuations, renewals or extensions thereof; and (iv) any registrations to be issued under any pending
applications. 
 “Default” means an event which with the giving of notice, passage of time, or both would constitute an Event of Default.

 “Default Rate” is defined in Section 2.7. 
 “Deposit Accounts” means any “deposit accounts,” as such term is defined in the UCC, now owned or hereafter acquired by Borrower or in which Borrower now holds or hereafter acquires any interest. 
 “Designated Rate” means the rate of interest per annum described in the Supplement as being applicable to an outstanding Loan from time to time.

 “Documents” means any “documents,” as such term is defined in the UCC, now owned or hereafter acquired by Borrower or in which
Borrower now holds or hereafter acquires any interest. 
 “Environmental Laws” means all federal, state or local laws, statutes, common law
duties, rules, regulations, ordinances and codes, together with all administrative orders, directed duties, requests, licenses, authorizations and permits of, and agreements with, any governmental authorities, in each case relating to environmental,
health, or safety matters. 
 “Equipment” means any “equipment,” as such term is defined in the UCC, now owned or hereafter
acquired by Borrower or in which Borrower now holds or hereafter acquires any interest and any and all additions, substitutions and replacements of any of the foregoing, wherever located, together with all attachments, components, parts, equipment
and accessories installed thereon or affixed thereto. 
 “Event of Default” means any event described in Section 7.1. 
 “Fixtures” means any “fixtures,” as such term is defined in the UCC, now owned or hereafter acquired by Borrower or in which Borrower now
holds or hereafter acquires any interest. 
 “GAAP” means generally accepted accounting principles and practices consistent with those
principles and practices promulgated or adopted by the Financial Accounting Standards Board and the Board of the American Institute of Certified Public Accountants, their respective predecessors and successors. Each accounting term used but not
otherwise expressly defined herein shall have the meaning given it by GAAP. 
 “General Intangibles” means any “general
intangibles,” as such term is defined in the UCC, now owned or hereafter acquired by Borrower or in which Borrower now holds or hereafter acquires any interest and, in any event, shall include, without limitation, all right, title and interest
that Borrower may now or hereafter have in or under any contract, all customer lists, Copyrights, Trademarks, Patents, websites, domain names, and all applications therefor and reissues, extensions, or renewals thereof, other rights to Intellectual
Property, interests in partnerships, joint ventures and other business associations, Licenses, permits, trade secrets, proprietary or confidential information, inventions (whether or not patented or patentable), technical information, procedures,
designs, knowledge, know-how, software, data bases, data, skill, expertise, recipes, experience, processes, models, drawings, materials and records, goodwill (including, without limitation, the goodwill associated with any Trademark, Trademark
registration or Trademark licensed under any Trademark License), claims in or under insurance policies, including unearned premiums, uncertificated securities, money, cash or cash equivalents, deposit, checking and other bank accounts, rights to sue
for past, present and future 

  

 17 

 
infringement of Copyrights, Trademarks and Patents, rights to receive tax refunds and other payments and rights of indemnification. 
 “Goods” means any “goods,” as such term is defined in the UCC, now owned or hereafter acquired by Borrower or in which Borrower now holds or
hereafter acquires any interest. 
 “Indebtedness” of any Person means at any date, without duplication and without regard to whether
matured or unmatured, absolute or contingent: (i) all obligations of such Person for borrowed money; (ii) all obligations of such Person evidenced by bonds, debentures, notes, or other similar instruments; (iii) all obligations of
such Person to pay the deferred purchase price of property or services, except trade accounts payable arising in the ordinary course of business; (iv) all obligations of such Person as lessee under capital leases; (v) all obligations of
such Person to reimburse or prepay any bank or other Person in respect of amounts paid under a letter of credit, banker’s acceptance, or similar instrument, whether drawn or undrawn; (vi) all obligations of such Person to purchase
securities which arise out of or in connection with the sale of the same or substantially similar securities; (vii) all obligations of such Person to purchase, redeem, exchange, convert or otherwise acquire for value any capital stock of such
Person or any warrants, rights or options to acquire such capital stock, now or hereafter outstanding, except to the extent that such obligations remain performable solely at the option of such Person; (viii) all obligations to repurchase
assets previously sold (including any obligation to repurchase any accounts or chattel paper under any factoring, receivables purchase, or similar arrangement); (ix) obligations of such Person under interest rate swap, cap, collar or similar
hedging arrangements; and (x) all obligations of others of any type described in clause (i) through clause (ix) above guaranteed by such Person. 
 “Insolvency Proceeding” means (a) any case, action or proceeding before any court or other governmental authority relating to bankruptcy, reorganization, insolvency, liquidation, receivership, dissolution, winding-up
or relief of debtors, or (b) any general assignment for the benefit of creditors, composition, marshalling of assets for creditors, or other, similar arrangement in respect of its creditors generally or any substantial portion of its creditors,
undertaken under U.S. Federal, state or foreign law, including the Bankruptcy Code. 
 “Instruments” means any “instrument,” as
such term is defined in the UCC, now owned or hereafter acquired by Borrower or in which Borrower now holds or hereafter acquires any interest. 
 “Intellectual Property” means all Copyrights, Trademarks, Patents, Licenses, trade secrets, source codes, customer lists, proprietary or confidential information, inventions (whether or not patented or patentable),
technical information, procedures, designs, knowledge, know-how, software, data bases, skill, expertise, experience, processes, models, drawings, materials, records and goodwill associated with the foregoing. 
 “Intellectual Property Security Agreement” means any Intellectual Property Security Agreement executed and delivered by Borrower in favor of Lender, as
the same may be amended, supplemented, or restated from time to time. 
 “Inventory” means any “inventory,” as such term is
defined in the UCC, wherever located, now owned or hereafter acquired by Borrower or in which Borrower now holds or hereafter acquires any interest, and, in any event, shall include, without limitation, all inventory, goods and other personal
property that are held by or on behalf of Borrower for sale or lease or are furnished or are to be furnished under a contract of service or that constitute raw materials, work in process or materials used or consumed or to be used or consumed in
Borrower’s business, or the processing, packaging, promotion, delivery or shipping of the same, and all finished goods, whether or not the same is in transit or in the constructive, actual or exclusive possession of Borrower or is held by
others for Borrower’s account, including, without limitation, all goods covered by purchase orders and contracts with suppliers and all goods billed and held by suppliers and all such property first may be in the possession or custody of any
carriers, forwarding agents, truckers, warehousemen, vendors, selling agents or other Persons. 
 “Investment Property” means any
“investment property,” as such term is defined in the UCC, now owned or hereafter acquired by Borrower or in which Borrower now holds or hereafter acquires any interest. 
 “Letter of Credit Rights” means any “letter of credit rights,” as such term is defined in the UCC, now owned or hereafter acquired by Borrower or in which Borrower now holds or hereafter
acquires any interest, including any right to payment under any letter of credit. 
  

 18 

 “License” means any Copyright License, Patent License, Trademark License or other license of rights or
interests now held or hereafter acquired by Borrower or in which Borrower now holds or hereafter acquires any interest and any renewals or extensions thereof. 
 “Lien” means any mortgage, deed of trust, pledge, hypothecation, assignment for security, security interest, encumbrance, levy, lien or charge of any kind, whether voluntarily incurred or arising by operation of law or
otherwise, against any property, any conditional sale or other title retention agreement, any lease in the nature of a security interest, and the filing of any financing statement (other than a precautionary financing statement with respect to a
lease that is not in the nature of a security interest) under the UCC or comparable law of any jurisdiction. 
 “Loan” means an extension of
credit by Lender under this Agreement. 
 “Loan Documents” means, individually and collectively, this Loan and Security Agreement, each
Supplement, each Note, the Intellectual Property Security Agreement, and any other security or pledge agreement(s), any Warrants issued by Borrower to Lender (or its designee) in connection with this Agreement, and all other contracts, instruments,
addenda and documents executed in connection with this Agreement or the extensions of credit which are the subject of this Agreement. 
 “Material
Adverse Effect” or “Material Adverse Change” means (a) a material adverse change in, or a material adverse effect upon, the operations, business, properties, or condition (financial or otherwise) of Borrower;
(b) a material impairment of the ability of Borrower to perform under any Loan Document; or (c) a material adverse effect upon the legality, validity, binding effect or enforceability against Borrower of any Loan Document. 
 “Maturity Date” means, with regard to a Loan, the earlier of (i) its maturity by reason of acceleration, or (ii) its stated maturity date; and
is the date on which payment of all outstanding principal, accrued interest, and the Terminal Payment with respect to such Loan is due. 
 “Note” means a promissory note substantially in the form attached to the Supplement as Exhibit “A”, executed by Borrower evidencing each Loan. 
 “Obligations” means all debts, obligations and liabilities of Borrower to Lender currently existing or now or hereafter made, incurred or created under, pursuant to or in connection with (i) this
Agreement or any other Loan Document and (ii) the VLL4 Loan Agreement, in each case,, whether voluntary or involuntary and however arising or evidenced, whether direct or acquired by Lender by assignment or succession, whether due or not due,
absolute or contingent, liquidated or unliquidated, determined or undetermined, and whether Borrower may be liable individually or jointly, or whether recovery upon such debt may be or become barred by any statute of limitations or otherwise
unenforceable; and all renewals, extensions and modifications thereof; and all attorneys’ fees and costs incurred by Lender in connection with the collection and enforcement thereof as provided for in any Loan Document. 
 “Patent License” means any written agreement granting any right with respect to any invention on which a Patent is in existence now owned or hereafter
acquired by Borrower or in which Borrower now holds or hereafter acquires any interest. 
 “Patents” means all of the following property now
owned or hereafter acquired by Borrower or in which Borrower now holds or hereafter acquires any interest: (a) all letters patent of, or rights corresponding thereto in, the United States or any other country, all registrations and recordings
thereof, and all applications for letters patent of, or rights corresponding thereto in, the United States or any other country, including, without limitation, registrations, recordings and applications in the United States Patent and Trademark
Office or in any similar office or agency of the United States, any State thereof or any other country; (b) all reissues, continuations, continuations-in-part or extensions thereof; (c) all petty patents, divisionals, and patents of
addition; and (d) all patents to be issued under any such applications. 
 “Permitted Lien” means 
 (a) Involuntary Liens which, in the aggregate, would not have a Material Adverse Effect and which in any event would not exceed, in the aggregate,
the Threshold Amount; 
 (b) Liens for current taxes or other governmental or regulatory assessments which are not delinquent, or
which are contested in good faith by the appropriate procedures and for which appropriate reserves are maintained; 
  

 19 

 (c) security interests on any property held or acquired by Borrower in the ordinary course of
business securing Indebtedness incurred or assumed for the purpose of financing all or any part of the cost of acquiring such property; provided, that such Lien attaches solely to the property acquired with such Indebtedness and that the
principal amount of such Indebtedness does not exceed one hundred percent (100%) of the cost of such property; 
 (d) Liens in
favor of Lender; 
 (e) bankers’ liens, rights of setoff and similar Liens incurred on deposits made in the ordinary course of
business; 
 (f) materialmen’s, mechanics’, repairmen’s, employees’ or other like Liens arising in the ordinary
course of business and which are not delinquent for more than 45 days or are being contested in good faith by appropriate proceedings; 
 (g) any judgment, attachment or similar Lien, unless the judgment it secures has not been discharged or execution thereof effectively stayed and bonded against pending appeal within 30 days of the entry thereof; 
 (h) exclusive and non-exclusive licenses of Intellectual Property; 
 (i) Liens which have been approved by Lender in writing prior to the Closing Date and are set forth on the Schedule of “Permitted Liens” attached hereto; 
 (j) Liens in favor of VLL4 granted pursuant to the VLL4 Loan Agreement; 
 (k) Liens securing Indebtedness permitted under Section 6.1(f) hereof; and 
 (l) Liens in favor of Bank (as defined in Section 6.1(g)) on the Credit Card Cash Collateral (hereinafter defined), securing the Indebtedness
permitted under Section 6.1(g) hereof. “Credit Card Cash Collateral” means a certificate of deposit or time deposit account maintained at Bank in the principal amount of approximately $50,000 pledged by Borrower to Bank to
secure Borrower’s obligations to Bank under a corporate credit card program arranged by Bank for the account of Borrower. 
 “Person” means any individual, sole proprietorship, partnership, joint venture, trust, unincorporated organization, association, corporation, limited liability company, institution, public benefit corporation, other entity
or government (whether federal, state, county, city, municipal, local, foreign, or otherwise, including any instrumentality, division, agency, body or department thereof). 
 “Proceeds” means “proceeds,” as such term is defined in the UCC and, in any event, shall include, without limitation, (a) any and all Accounts, Chattel Paper, Instruments, cash or other
forms of money or currency or other proceeds payable to Borrower from time to time in respect of the Collateral, (b) any and all proceeds of any insurance, indemnity, warranty or guaranty payable to Borrower from time to time with respect to
any of the Collateral, (c) any and all payments (in any form whatsoever) made or due and payable to Borrower from time to time in connection with any requisition, confiscation, condemnation, seizure or forfeiture of all or any part of the
Collateral by any governmental authority (or any Person acting under color of governmental authority), (d) any claim of Borrower against third parties (i) for past, present or future infringement of any Copyright, Patent or Patent License
or (ii) for past, present or future infringement or dilution of any Trademark or Trademark License or for injury to the goodwill associated with any Trademark, Trademark registration or Trademark licensed under any Trademark License and
(e) any and all other amounts from time to time paid or payable under or in connection with any of the Collateral. 
 “Qualified Public
Offering” means the closing of a firmly underwritten public offering of Borrower’s common stock with aggregate proceeds of not less than $20,000,000 (prior to underwriting expenses and commissions). 
 “Receivables” means all of Borrower’s Accounts, Instruments, Documents, Chattel Paper, Supporting Obligations, and letters of credit and Letter of
Credit Rights. 
 “Records” means all Borrower’s computer programs, software, hardware, source codes and data processing information,
all written documents, books, invoices, ledger sheets, financial information and statements, and all other writings concerning Borrower’s business. 
 “Related Person” means any Affiliate of Borrower, or any officer, employee, director or equity security holder of Borrower or any Affiliate. 
  

 20 

 “Rights to Payment” means all Borrower’s accounts, instruments, contract rights, documents, chattel
paper and all other rights to payment, including, without limitation, the Accounts, all negotiable certificates of deposit and all rights to payment under any Patent License, any Trademark License, or any commercial or standby letter of credit.

 “Security Documents” means this Loan and Security Agreement, the Supplement hereto, the Intellectual Property Security Agreement, and any
and all account control agreements, collateral assignments, chattel mortgages, financing statements, amendments to any of the foregoing and other documents from time to time executed or filed to create, perfect or maintain the perfection of
Lender’s Liens on the Collateral. 
 “Supplement” means that certain supplement to the Loan and Security Agreement, as the same may be
amended or restated from time to time, and any other supplements entered into between Borrower and Lender, as the same may be amended or restated from time to time. 
 “Supporting Obligations” means any “supporting obligations,” as such term is defined in the UCC, now owned or hereafter acquired by Borrower or in which Borrower now holds or hereafter
acquires any interest. 
 “Terminal Payment” means, with respect to a Loan, an amount payable on the Maturity Date of such Loan in an amount
equal to that percentage of the original principal amount of such Loan specified in the Supplement. 
 “Termination Date” has the meaning
specified in the Supplement. 
 “Threshold Amount” has the meaning specified in the Supplement. 
 “Trademark License” means any written agreement granting any right to use any Trademark or Trademark registration now owned or hereafter acquired by
Borrower or in which Borrower now holds or hereafter acquires any interest. 
 “Trademarks” means all of the following property now owned or
hereafter acquired by Borrower or in which Borrower now holds or hereafter acquires any interest: (a) all trademarks, tradenames, corporate names, business names, trade styles, service marks, logos, other source or business identifiers, prints
and labels on which any of the foregoing have appeared or appear, designs and general intangibles of like nature, now existing or hereafter adopted or acquired, all registrations and recordings thereof, and any applications in connection therewith,
including, without limitation, registrations, recordings and applications in the United States Patent and Trademark Office or in any similar office or agency of the United States, any State thereof or any other country or any political subdivision
thereof and (b) reissues, extensions or renewals thereof. 
 “UCC” means the Uniform Commercial Code as the same may, from time to
time, be in effect in the State of California; provided, that in the event that, by reason of mandatory provisions of law, any or all of the attachment, perfection or priority of, or remedies with respect to, Lender’s Lien on any
Collateral is governed by the Uniform Commercial Code as enacted and in effect in a jurisdiction other than the State of California, the term “UCC” shall mean the Uniform Commercial Code as enacted and in effect in such other jurisdiction
solely for purposes of the provisions thereof relating to such attachment, perfection, priority or remedies and for purposes of definitions related to such provisions. Unless otherwise defined herein, terms that are defined in the UCC and used
herein shall have the meanings given to them in the UCC. 
 “VLL4 Loan Agreement” means, collectively, that certain Loan and Security
Agreement dated as of December 1, 2004, between Borrower and VLL4, together with all of the “Loan Documents” (as such term is defined therein). 
 [Signature page follows] 
  

 21 

 [Signature page to Loan and Security Agreement] 
 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above written. 
  

			
	 BORROWER:

	
	 ENTEROMEDICS INC.

		
	 By:
	 	 /s/ Mark B. Knudson
  

		
	 Name:
	 	 Mark B. Knudson
  

		
	 Title:
	 	 President & CEO
  

	
	 LENDER:

	
	 VENTURE LENDING & LEASING IV, INC.

		
	 By:
	 	 /s/ Ronald W. Swenson
  

		
	 Name:
	 	 Ronald W. Swenson
  

		
	 Title:
	 	 CEO
  

	
	 LENDER:

	
	 VENTURE LENDING & LEASING V, INC.

		
	 By:
	 	 /s/ Ronald W. Swenson
  

		
	 Name:
	 	 Ronald W. Swenson
  

		
	 Title:
	 	 CEO
  

 [Schedules to Loan and Security Agreement follow] 

 Schedule 6.1 – Indebtedness 
 None. 

 Schedule of Permitted Liens 
 None.Supplement to the Loan and Security Agreement

 EXHIBIT 10.7 
 SUPPLEMENT 
 to the 
 Loan and Security Agreement 
 Dated as of May 17, 2007 
 between 
 EnteroMedics Inc.
(“Borrower”) 
 and 
 Venture Lending & Leasing IV, Inc. (“VLL4”) 
 and 
 Venture Lending & Leasing V, Inc. (“VLL5”) 
 (each of VLL4 and VLL5, as “Lender”) 
 This is a Supplement identified in the document
entitled Loan and Security Agreement dated as of May 17, 2007, between Borrower and Lender (the “Loan and Security Agreement”). All capitalized terms used in this Supplement and not otherwise defined in this Supplement have the
meanings ascribed to them in Section 10 of the Loan and Security Agreement, which is incorporated in its entirety into this Supplement. In the event of any inconsistency between the provisions of that document and this Supplement, this
Supplement is controlling. 
 The parties are entering into this single Supplement to the Loan and Security Agreement for convenience, and
this Supplement is and shall be interpreted for all purposes as separate and distinct agreements between Borrower and VLL4, on the one hand, and Borrower and VLL5, on the other hand, and nothing in this Supplement shall be deemed a joint venture,
partnership or other association between VLL4 and VLL5. Each reference in this Supplement to “Lender” shall mean and refer to each of VLL4 and VLL5, singly and independent of one another. Without limiting the generality of the foregoing,
the Commitment, covenants and other obligations of “Lender” under the Loan and Security Agreement, as supplemented hereby, are several and not joint obligations of VLL4 and VLL5, and all rights and remedies of “Lender” under the
Loan and Security Agreement, as supplemented hereby, may be exercised by VLL4 and/or VLL5 independently of one another. 
 In addition to the
provisions of the Loan and Security Agreement, the parties agree as follows: 
 Part 1.—Additional Definitions:

 “Commitment” means, as the context may require, the VLL4 Commitment or the VLL5 Commitment. Each Lender’s
Commitment is several and not joint with the Commitment of the other Lender. 
 “Cash Equivalents” means, as of any date of
determination, the following assets or rights of Borrower: (i) marketable direct obligations issued or unconditionally guaranteed by the United States government having maturities of not more than 12 months from the date of acquisition; and
(ii) domestic certificates of deposit and time deposits having maturities of not more than 12 months from the date of acquisition, and overnight bank deposits, in each case issued by a commercial bank organized under the laws of the United
States or any state thereof which at the time of acquisition are rated A-1 or better by Standard & Poor’s Corporation (or equivalent), and not subject to any offset rights in favor of such bank arising from any banking relationship
with such bank. 
 “Designated Rate” means, for each Growth Capital Loan, a fixed rate of interest per annum equal to the
Prime Rate as published on the Business Day on which Lender prepares the Note for such Loan following Borrower’s submission of the Borrowing Request therefor, plus two percent (2.00%); provided, however, that in no event shall the
Designated Rate for a Growth Capital Loan be less than ten and one-quarter of one percent (10.25%). 
  

 “Four Months’ Expenses” means, as of any date of determination the aggregate dollar
amount of operating and other expenses paid and accrued and cash expended (without duplication) by Borrower during the four calendar months most recently ended. 
 “Growth Capital Loan” means any Loan requested by Borrower and funded by Lender under its Commitment for general corporate purposes of Borrower. Growth Capital Loans are sometimes referred to herein
individually as a “Loan” or collectively as “Loans”. 
 “Interest-Only Rate”: The
Interest-Only Rate for each Growth Capital Loan shall be a fixed rate of interest per annum equal to the Prime Rate as published on the Business Day on which Lender prepares the Note for such Loan, plus four and 23/100 percent (4.23%); provided,
however, that in no event shall the Interest-Only Rate for a Growth Capital Loan be less than twelve and 48/100 percent (12.48%). 
 “Prime Rate” means the “prime rate” of interest, as published from time to time by The Wall Street Journal in the “Money Rates” section of its Western Edition newspaper. 
 “Terminal Payment”: Each Growth Capital Loan shall have a Terminal Payment equal to three and one-tenth of one percent (3.1%) of
the original principal amount of such Loan. 
 “Termination Date”: The Termination Date is the earlier of: (i) the date
Lender may terminate making Loans or extending other credit pursuant to the rights of Lender under Article 7 of the Loan and Security Agreement, or (ii)(A) with respect to the First Tranche of the Commitment, May 25, 2007; and
(B) with respect to the Second Tranche of the Commitment, August 31, 2007. 
 “Threshold Amount” means
Fifty Thousand Dollars ($50,000). 
 “Unrestricted Cash” means, as of any date of determination, Borrower’s cash on
hand and Cash Equivalents which are not subject to a Lien of any Person other than Lender. 
 “VLL4 Commitment”: Subject to
the terms and conditions set forth in the Loan and Security Agreement and this Supplement, VLL4 commits to make Growth Capital Loans to Borrower up to the aggregate original principal amount of Five Million Dollars ($5,000,000) for general corporate
purposes. The VLL4 Commitment shall be divided into two equal tranches in the amount of Two Million Five Hundred Thousand Dollars ($2,500,000) each, which shall be referred to herein as the “First Tranche” and the “Second
Tranche”, respectively, of the VLL4 Commitment. 
 “VLL5 Commitment”: Subject to the terms and conditions set forth
in the Loan and Security Agreement and this Supplement, VLL5 commits to make Growth Capital Loans to Borrower up to the aggregate original principal amount of Five Million Dollars ($5,000,000) for general corporate purposes. The VLL5 Commitment
shall be divided into two equal tranches in the amount of Two Million Five Hundred Thousand Dollars ($2,500,000) each, which shall be referred to herein as the “First Tranche” and the “Second Tranche”, respectively,
of the VLL5 Commitment. 
 Part 2.—Additional Covenants and Conditions: 
 1. Commitment; Use of Proceeds; Limitations on Loans. 
 (a) Growth Capital Loans. Subject to the terms and conditions of the Loan and Security Agreement and this Supplement, Lender agrees to make Growth Capital Loans to Borrower from time to time from the Closing
Date up to and including the applicable Termination Date in an aggregate original principal amount up to but not exceeding the then unfunded portion of Lender’s Commitment. Borrowing Request(s) for Growth Capital Loans shall be applied first to
the First Tranche of Lender’s Commitment until either (i) the First Tranche has been 

  

 2 

 
fully utilized or (ii) the Termination Date of the First Tranche has occurred; then such Borrowing Request(s) for Growth Capital Loans shall be applied
against the Second Tranche of Lender’s Commitment until either (i) the Second Tranche has been fully utilized or (ii) the Termination Date of the Second Tranche has occurred. The proceeds of each Growth Capital Loan shall be used by
Borrower for general corporate purposes. 
 (b) Minimum Funding Amount. Except to the extent the remaining Commitment is a lesser
amount, any Growth Capital Loans requested by Borrower to be made on a single Business Day shall be for a minimum aggregate principal amount of Two Million Five Hundred Thousand Dollars ($2,500,000). Borrower shall not submit a Borrowing Request for
Loans more frequently than once each calendar month. 
 (c) Repayment of Growth
Capital Loans. Principal of and interest on each Growth Capital Loan shall be payable as set forth in a Note (substantially in the form of Exhibit “A” hereto) evidencing such Loan, which Note shall provide substantially as
follows: principal and interest at the Designated Rate shall be fully amortized over a period of 30 months in equal, monthly installments, commencing after an initial 6-month period of interest-only, monthly payments. In particular, on the Borrowing
Date applicable to the Growth Capital Loan evidenced by such Note, Borrower shall pay to Lender (i) if the Borrowing Date is not the first day of the month interest only at the Interest-Only Rate, in advance, on the outstanding principal
balance of the Loan evidenced by such Note, for the period from such Borrowing Date through the last day of the calendar month in which such Borrowing Date occurs, and (ii) a first (1st) interest only installment at the Interest-Only Rate, in advance, on the outstanding principal balance of the Note for the ensuing month. Commencing on
the first day of the second full month after the Borrowing Date, and continuing on the first day of the third through the sixth full months after the Borrowing Date, Borrower shall pay interest only at the Interest-Only Rate, in advance, on the
outstanding principal balance of this Note for the ensuing month. Commencing on the first day of the seventh full calendar month after the Borrowing Date, and continuing on the first day of each consecutive calendar month thereafter, principal and
interest at the Designated Rate shall be payable, in advance, in 30 equal consecutive installments in an amount sufficient to fully amortize the Loan evidenced by such Note. Borrower shall pay the Terminal Payment on the date of the last
amortization payment. 
 2. Voluntary Prepayment. No Loan may be voluntarily prepaid except as provided in this Section 2.
Borrower may voluntarily prepay all, but not less than all, Loans in whole, but not in part, at any time by tendering to Lender cash payment in respect of such Loans in an amount equal to: (i) all accrued and unpaid Basic Interest on such Loans
as of the date of prepayment; (ii) the Terminal Payments on such Loans; and (iii) an amount equal to the undiscounted, total amount of all installment payments of principal and Basic Interest that would have accrued and been payable from
the date of prepayment through the stated Maturity Date of the Loans had such Loans remained outstanding and been paid in accordance with the terms of the related Notes. 
 3. Subordination of Debt. During the term of the Loan and Security Agreement and until performance of all Obligations to Lender, Borrower shall not incur any Indebtedness for new borrowed money (except for
Indebtedness permitted under Section 6.1 of the Loan and Security Agreement) after the date hereof unless approved by Lender and where the holder’s right to repayment of such Indebtedness, the priority of any Lien securing the same, and
the rights of the holder thereof to enforce remedies against Borrower following default have been made subordinate to the Liens of Lender and the prior payment of the Obligations to Lender under the Loan Documents pursuant to a written subordination
agreement approved by Lender in its sole discretion in writing, which agreement may provide that regularly scheduled payments of accrued interest on such subordinated Indebtedness may be paid by Borrower and retained by the holder so long as no
Event of Default has occurred. 
 4. Issuance of Warrants. 
 (a) As additional consideration for the making of its Commitment, VLL4 or its assignee has earned and shall have received, upon the execution
hereof and as a condition to the initial Loan, a warrant instrument issued by Borrower (the “VLL4 Warrant”), initially exercisable for 309,231 fully paid and nonassessable shares of Borrower’s Series C Preferred Stock at an
initial exercise price of $0.8893 per share (the “Stock Purchase Price”); provided, however, that such initial number of shares of Series C Preferred Stock 

  

 3 

 
issuable under the VLL4 Warrant at the Stock Purchase Price shall be increased automatically from time to time by that number of additional shares determined
by dividing (i) the product of (A) 0.055 and (B) the aggregate original principal amount of the Growth Capital Loans funded by VLL4 by (ii) the Stock Purchase Price. 
 (b) As additional consideration for the making of its Commitment, VLL5 or its assignee has earned and shall have received, upon the execution
hereof and as a condition to the initial Loan, a warrant instrument issued by Borrower (the “VLL5 Warrant” and together with the VLL4 Warrant, the “Warrants”), initially exercisable for 309,231 fully paid and
nonassessable shares of Borrower’s Series C Preferred Stock at an initial exercise price per share equal to the Stock Purchase Price; provided, however, that such initial number of shares of Series C Preferred Stock issuable under the
VLL5 Warrant at the Stock Purchase Price shall be increased automatically from time to time by that number of additional shares determined by dividing (i) the product of (A) 0.055 and (B) the aggregate original principal amount of the
Growth Capital Loans funded by VLL5 by (ii) the Stock Purchase Price. 
 (c) The Warrants shall be in substantially the form
attached hereto as Exhibit “E” and immediately vested and exercisable at any time and from time to time through August 31, 2014. The foregoing exercise price per share and number of shares issuable upon exercise of the Warrants
shall also be subject to adjustment as provided in the Warrants. The Warrants shall include piggyback and S-3 registration rights, anti-dilution protections reasonably satisfactory to Lender and equivalent to those rights and protections granted to
the holders of Borrower’s Series C Preferred Stock, and shall remain exercisable beyond any public offering of Borrower’s securities or merger transaction. Borrower acknowledges that: (i) VLL4 has assigned its rights to receive the
VLL4 Warrant to its parent, Venture Lending & Leasing IV, LLC; and (ii) VLL5 has assigned its rights to receive the VLL5 Warrant to its parent, Venture Lending & Leasing V, LLC. In connection therewith, Borrower shall issue
the VLL4 Warrant directly to Venture Lending & Leasing IV, LLC, and Borrower shall issue the VLL5 Warrant directly to Venture Lending & Leasing V, LLC. Upon request of Borrower, Lender shall furnish to Borrower a copy of the
agreement in which Lender assigned its Warrant to its parent. 
 5. Lien on Intellectual Property. In reliance on Borrower’s
covenant in Section 6.2 of the Loan and Security Agreement to keep all of its Intellectual Property assets free and clear of Liens other than as set forth in Section 6.2, Lender has agreed initially to exclude Intellectual Property from
the Collateral over which Borrower has granted to Lender a Lien to secure the Obligations. Borrower agrees that if at any time the ratio of its Unrestricted Cash to Four Months’ Expenses is less than one-to-one (1:1), then the definition of
Collateral in Article 10 of the Loan and Security Agreement shall be automatically and immediately, without any further action or writing required by the parties, amended to delete the final proviso thereof, such that all of Borrower’s
Intellectual Property then owned and thereafter arising or acquired becomes part of the Collateral for all purposes of the Loan and Security Agreement. In the event the definition of Collateral has been amended as set forth in this Section 5
and no Event of Default has occurred and is then continuing, Borrower shall be able to continue to license, exclusively and non-exclusively, its Intellectual Property to other Persons in the ordinary course of its business, on terms consistent with
industry practice, for fair consideration and with the consent of Borrower’s Board of Directors. Borrower and Lender agree to execute and deliver, at Borrower’s sole cost and expense, all documents and instruments necessary to perfect such
Lien when it is created, including an Intellectual Property Security Agreement, substantially the form attached hereto as Exhibit “D”. For clarity, the Intellectual Property Security Agreement will not be executed and delivered
until such time as the Lender’s security interest includes Intellectual Property in accordance with the terms of this Section 5. Lender agrees that if at any time after its security interest includes Intellectual Property the ratio of
Borrower’s Unrestricted Cash to Four Months’ Expenses is greater than one-to-one (1:1) then the Lender’s Lien as to that portion of the Collateral consisting of Intellectual Property shall be automatically and immediately,
without any further action or writing required by the parties, released and the definition of Collateral in Article 10 of the Loan and Security Agreement shall be automatically and immediately, without any further action or writing required by the
parties, amended to restate the final proviso thereof, such that the Collateral shall no longer include Borrower’s Intellectual Property (subject to further amendment if at any time after such restatement the ratio of its Unrestricted
Cash to Four Months’ Expenses is less than one-to-one (1:1)). 
 6. Forbearance of Exercise of Remedies Against Intellectual
Property. 
  

 4 

 (a) Notwithstanding anything to the contrary contained in Article 7 and 8 of the Loan and Security
Agreement or elsewhere in the Loan Documents, following the occurrence and during the continuance of an Event of Default, other than an Event of Default under Section 7.1(c) of the Loan and Security Agreement involving a voluntary Insolvency
Proceeding or dissolution of Borrower or termination of Borrower’s business, or an Event of Default under Section 7.1(f) or (h) of the Loan and Security Agreement, if at such time Lender has a Lien on Intellectual Property pursuant to
Section 5 above, Lender agrees to forbear from selling, leasing, licensing or otherwise disposing of any Collateral comprising Intellectual Property for a period of up to sixty (60) days after the occurrence of such Event of Default (such
period being referred to herein as a “Forbearance Period”), provided that at all times during the Forbearance Period: 
  

	 	(i)	Borrower shall continue to have a duly constituted and acting board of directors, and executive management working on a full time basis for Borrower; 

  

	 	(ii)	Borrower is able to demonstrate to the reasonable satisfaction of Lender that Borrower is exercising on a continuous and diligent basis reasonable commercial efforts to consummate a
financing or other transaction that will enable it to satisfy and discharge its Obligations to Lender; 

  

	 	(iii)	Borrower shall cooperate with Lender in its exercise of rights under Sections 5.3(a)(i), 5.3(b) and 5.9(a) of the Loan and Security Agreement; 

  

	 	(iv)	No Insolvency Proceeding is commenced by or against Borrower; and 

  

	 	(v)	No Person who holds or acquires a Lien on or against all or any material portion of Borrower’s Intellectual Property actually exercises foreclosure or similar remedies against
such property. 

 Subject to paragraph (b) below, upon the failure of Borrower to comply with any of the conditions described in clauses
(i) through (v) above, the Forbearance Period shall immediately and automatically terminate and Lender may thereupon commence, continue and complete any exercise of its rights and remedies against Intellectual Property Collateral, all as
provided in the Loan Documents and under applicable law. 
 (b) If during the Forbearance Period, Lender proposes or arranges a private or
public sale of all or a material portion of the Intellectual Property Collateral (which sale shall not be consummated during the Forbearance Period), Lender shall give notice of such proposed sale to Borrower, including notice of the minimum price
to be paid or bid in such sale. If Borrower’s Board of Director determines in good faith that the proposed sale would not be commercially reasonable, then Borrower may, within ten (10) Business Days of receipt of the initial notice from
Lender, deliver a written objection, following which the parties agree to meet promptly and to confer in good faith to resolve any disagreements as to value or the proposed sale. Unless the parties have otherwise agreed as a result of such
meet-and-confer, Borrower shall obtain, at its sole expense, within sixty (60) days after the initial notice from Lender, a written appraisal of the orderly liquidation value of the Intellectual Property, prepared by a recognized, independent
appraiser with experience evaluating similar types of property (in which event, the sixty (60)-day limitation on the Forbearance Period shall be extended if, and only as, necessary to afford Borrower the full sixty (60) days to obtain such
appraisal). If such appraisal is not timely delivered, or if the value concluded by the independent appraisal is not more than one hundred twenty percent (120%) of the minimum price or bid in any transaction proposed by Lender for the same
Intellectual Property Collateral, then Lender may proceed with the proposed transaction (but not sooner than one hundred twenty (120) days after the occurrence of an Event of Default unless Borrower approves otherwise) on price terms not
materially more favorable to the transferee than originally proposed by Lender. If the value concluded by the independent appraisal is more than one hundred twenty percent (120%) of the minimum price or bid in any transaction proposed by
Lender, then the sixty (60)-day limitation on the Forbearance Period (as may have been extended for the appraisal as aforesaid) shall be extended and the parties shall cooperate with one another to realize the higher valuation, provided that if the
Forbearance Period (as so extended) terminates for any reason other than that set forth in clause (ii) of paragraph (a) above, Lender may thereupon commence, continue and complete any exercise of its rights and remedies against
Intellectual Property 

  

 5 

 
Collateral, all as provided in the Loan Documents and under applicable law, and in all events, Lender shall be free to enforce such rights and remedies and
complete one or more sales or other dispositions of the Intellectual Property after the earlier of (i) one hundred eighty (180) days after the occurrence of the Event of Default, or (ii) one hundred twenty (120) days after the
delivery of the appraisal report to Borrower. 
 (c) At any time during the Forbearance Period, Lender will discontinue and forbear from
enforcing its rights and remedies against the Collateral upon tender to Lender by Borrower or by another Person for its account all amounts payable under Section 2 of Part 2 hereunder. 
 7. Completion of Due Diligence; Payment and Disposition of Commitment Fee. As an additional condition precedent under Section 4.1 of the Loan
and Security Agreement, Lender shall have completed to its satisfaction its due diligence review of Borrower’s business and financial condition and prospects, and Lender’s investment committee shall have approved its Commitment. If this
condition is not satisfied, the One Hundred Thousand Dollars ($100,000) commitment fee (the “Commitment Fee”) previously paid by Borrower shall be refunded. Each Lender agrees that with respect to each Growth Capital Loan advanced
by it under its Commitment, on the Borrowing Date applicable to such Loan, such Lender shall credit against the payments due from Borrower on such date in respect of such Loan an amount equal to the product of Fifty Thousand Dollars ($50,000) and a
fraction the numerator of which is the principal amount of such Loan and the denominator of which is Five Million Dollars ($5,000,000), until the aggregate amount of such credits by such Lender equals but does not exceed Fifty Thousand Dollars
($50,000). Except as set forth in this section, the Commitment Fee is not refundable. 
 8. Debits to Account for ACH Transfers. For
purposes of Section 2.2 and 5.10 of the Loan and Security Agreement, Borrower’s Primary Operating Account is: 
  

			
		 	 Wells Fargo Bank

		 	 430 N. Wabasha St., Suite 302, St. Paul, MN 55101

		 	 Routing No.: xxxxx

		 	 Account No.: xxxxx

		 	 For Further Credit to: EnteroMedics Inc.

		 	 Contact: Charlie Roehl

		 	 Phone: 651-205-9658

		 	 Email: Charles.Roehl@wellsfargo.com

 Loans will be advanced to the account specified above and payments will be automatically debited from the same
account. 
 9. Documentation Fee Payment. Pursuant to Section 9.8(a) of the Loan and Security Agreement, Borrower shall pay to
Lender, on demand, Lender’s reasonable and actual attorneys’ fees, costs and expenses incurred and expended in connection with the preparation and negotiation of the Loan Documents, and shall reimburse Lender for Lender’s
out-of-pocket costs of perfecting its Liens against Collateral. 
 Part 3.—Additional Representations: 
 Borrower represents and warrants that as of the Closing Date and each Borrowing Date: 
  

	 	a)	Its chief executive office is located at: 2800 Patton Road, St. Paul, MN 55113. 

  

	 	b)	Its Equipment is located at: same as above. 

  

	 	c)	Its Inventory is located at: same as above. 

  

	 	d)	Its Records are located at: same as above. 

  

 6 

	 	e)	In addition to its chief executive office, Borrower maintains offices or operates its business at the following locations: None. 

  

	 	f)	Other than its full corporate name, Borrower has conducted business using the following trade names or fictitious business names: Beta Medical. 

  

	 	g)	Borrower’s Delaware state corporation I.D. number is 3832130. 

  

	 	h)	Borrower’s federal tax identification number is 48-1293684. 

  

	 	i)	Borrower’s Other Deposit and Investment Accounts: In addition to Borrower’s Primary Operating Account at Wells Fargo Bank identified above, Borrower
maintains to following other deposit and investment accounts: 

  

					
		 	1.	  	Institution: Wells Fargo Institutional Brokerage & Sales
		 		  	Address: 608 Second Avenue North, 10th Floor, Minneapolis, MN 55479-0145
		 		  	Account Type: securities
		 		  	Account No.: xxxxx
		 		  	Contact: Shale Nyberg
		 		  	Phone: 612-667-4659
		 		  	Email: shale.a.nyberg@wellsfargo.com
			
		 	2.	  	Institution: Silicon Valley Bank Asset Management
		 		  	Address: 185 Berry Street, Lobby 1, Suite 3000, San Francisco, CA 94107
		 		  	Account type: securities
		 		  	Account No.: xxxxx
		 		  	Contact: Sonia Calvo
		 		  	Phone: 415-512-4267
		 		  	Email: scalvo@svb.com

 Part 4.—Additional Loan Documents: 
  

					
		 	Form of Note	  	Exhibit “A”
		 	Form of Borrowing Request	  	Exhibit “B”
		 	Form of Compliance Certificate	  	Exhibit “C”
		 	Form of Intellectual Property Security Agreement	  	Exhibit “D”
		 	Form of Warrant	  	Exhibit “E”
		 	Form of Legal Opinion	  	Exhibit “F”

 [Signature page follows.] 
  

 7 

 [Signature Page to Supplement to Loan and Security Agreement] 
 IN WITNESS WHEREOF, the parties have executed this Supplement as of the date first above written. 
  

									
		 		 	BORROWER:	 	
				
		 		 	ENTEROMEDICS INC.	 	
					
		 		 	By:	 	 /s/ Mark B. Knudson
	 	
		 		 	Name:	 	 Mark B. Knudson
	 	
		 		 	Title:	 	 President & CEO
	 	
					
	Address for Notices:	 		 	Attn:	 	 Mark B. Knudson
	 	
		 		 		 	2800 Patton Road	 	
		 		 		 	St. Paul, MN 55113	 	
		 		 	Fax #:	 	 651-789-2758
	 	
				
		 		 	LENDER:	 	
			
		 		 	VENTURE LENDING & LEASING IV, INC.
					
		 		 	By:	 	 /s/ Ronald W. Swenson
	 	
		 		 	Name:	 	 Ronald W. Swenson
	 	
		 		 	Title:	 	 CEO
	 	
					
	Address for Notices:	 		 	Attn: 	 	Chief Financial Officer	 	
		 		 		 	2010 North First Street, Suite 310	 	
		 		 		 	San Jose, California 95131	 	
		 		 	Fax #: 	 	(408) 436-8625	 	
				
		 		 	LENDER:	 	
			
		 		 	VENTURE LENDING & LEASING V, INC.
					
		 		 	By:	 	 /s/ Ronald W. Swenson
	 	
		 		 	Name:	 	 Ronald W. Swenson
	 	
		 		 	Title:	 	 CEO
	 	
					
	Address for Notices:	 		 	Attn: 	 	Chief Financial Officer	 	
		 		 		 	2010 North First Street, Suite 310
		 		 		 	San Jose, California 95131
		 		 	Fax #:	 	(408) 436-8625	 	

  

 EXHIBIT “A” 
 FORM OF PROMISSORY NOTE 
 (Growth Capital Loans) 
 [Note No. X-XXX] 
  

			
	 $            
	  	                    , 2004

 San Jose, California 
 The undersigned (“Borrower”) promises to pay to the order of VENTURE LENDING & LEASING [IV/V], INC., a Maryland corporation (“Lender”), at its office at 2010 North First Street,
Suite 310, San Jose, California 95131, or at such other place as Lender may designate in writing, in lawful money of the United States of America, the principal sum of
                     Dollars ($            ), with Basic Interest thereon
from the date hereof until maturity, whether scheduled or accelerated, at a fixed rate per annum equal to [the Prime Rate (as defined in the Loan Agreement referred to below) as published on the Business Day on which Lender prepares this Note
following Borrower’s submission of the Borrowing Request therefor, plus 2.00% but not less than 10.25%) (the “Designated Rate”), except as otherwise provided herein, according to the payment schedule described herein, and a
Terminal Payment in the sum of [3.10% of face amount of Loan] Dollars ($            ) payable on the Maturity Date. 
 This Note is one of the Notes referred to in, and is entitled to all the benefits of, a Loan and Security Agreement dated as of May
    , 2007, between Borrower and Lender (as amended, restated and supplemented from time to time, the “Loan Agreement”). Each capitalized term not otherwise defined herein shall have the meaning set forth in the
Loan Agreement. The Loan Agreement contains provisions for the acceleration of the maturity of this Note upon the happening of certain stated events. 
 Principal of and interest on this Note shall be payable as follows: 
 On the Borrowing Date, Borrower shall
pay [if the Borrowing Date is not the first day of the month interest at a rate equal to [the Prime Rate as published on the Business Day on which Lender prepares this Note plus 4.23%, but in no event less than 12.48%], in
advance, on the outstanding principal balance of this Note for the period from the Borrowing Date through     [the last day of the same month]        ; and (ii)]
interest only at a rate equal to [the Prime Rate as published on the Business Day on which Lender prepares this Note plus 4.23%, but in no event less than 12.48%] (the “Interest-Only Rate”) in advance, on the outstanding
principal balance of this Note in the amount of $             for the month of [date of first regular interest only payment]. 
 Commencing on the first day of the second full month after the Borrowing Date, and continuing on the first day of the third through the sixth full months
after the Borrowing Date, Borrower shall make payments, in advance, of interest only at the Interest-Only Rate on the principal balance outstanding hereunder in the amount of
$             each. 
 Commencing on the first day of the seventh
full month after the Borrowing Date, and continuing on the first day of each consecutive month thereafter, principal and Basic Interest at the Designated Rate shall be payable, in advance, in thirty (30) equal consecutive installments of
                     Dollars ($            ) each. The Terminal Payment and
unpaid expenses, fees, interest and principal amount shall be due and payable on                      200    .]

 This Note may be voluntarily prepaid only as permitted under Section 2 of Part 2 of the Supplement to the Loan Agreement. 

 

 Any unpaid payments of principal or interest on this Note shall bear interest from their respective
maturities, whether scheduled or accelerated, at a rate per annum equal to the Default Rate. Borrower shall pay such interest on demand. 
 Interest, charges and fees shall be calculated for actual days elapsed on the basis of a 360-day year, which results in higher interest, charge or fee payments than if a 365-day year were used. In no event shall Borrower be obligated to pay
interest, charges or fees at a rate in excess of the highest rate permitted by applicable law from time to time in effect. 
 If Borrower is
late in making any payment under this Note by more than five (5) Business Days, Borrower agrees to pay a “late charge” of five percent (5%) of the installment due, but not less than fifty dollars ($50.00) for any one such
delinquent payment. This late charge may be charged by Lender for the purpose of defraying the expenses incidental to the handling of such delinquent amounts. Borrower acknowledges that such late charge represents a reasonable sum considering all of
the circumstances existing on the date of this Note and represents a fair and reasonable estimate of the costs that will be sustained by Lender due to the failure of Borrower to make timely payments. Borrower further agrees that proof of actual
damages would be costly and inconvenient. Such late charge shall be paid without prejudice to the right of Lender to collect any other amounts provided to be paid or to declare a default under this Note or any of the other Loan Documents or from
exercising any other rights and remedies of Lender. 
 This Note shall be governed by, and construed in accordance with, the laws of the
State of California, without regard to its conflict of laws provisions. 
  

					
		 	 ENTEROMEDICS INC.

			
		 	 By:
	 	  

		 	 Name:
	 	  

		 	 Its:
	 	  

  

 EXHIBIT “B” 
 FORM OF BORROWING REQUEST 
 [Date] 
 Venture Lending & Leasing [IV/V], Inc. 
 2010 North First Street, Suite 310 
 San Jose, CA 95131 
  

	Re:	EnteroMedics Inc. 

 Ladies and Gentlemen: 
 Reference is made to the Loan and Security Agreement dated as of May     , 2007 (as amended, restated and supplemented from
time to time, the “Loan Agreement”, the capitalized terms used herein as defined therein), between Venture Lending & Leasing [IV/V], Inc. (“Lender”) and EnteroMedics Inc. (the “Company”). 
 The undersigned is the                      of
the Company, and hereby requests on behalf of the Company a Loan under the Loan Agreement, and in that connection certifies as follows: 
 1.
The amount of the proposed Loan is                      and     /100 Dollars
($            ). The Borrowing Date of the proposed Loan is
                    , 200    . 
 2. As of this date, no Default or Event of Default has occurred and is continuing, or will result from the making of the proposed Loan, the representations and warranties of the Company contained in Article 3 of
the Loan Agreement are true and correct in all material respects, and the conditions precedent described in Article 4 of the Loan Agreement have been met. 
 3. No event that has had or could reasonably be expected to have a Material Adverse Change has occurred. 
 4. The Company’s most recent financial projections dated                     , as approved by the Company’s Board of
Directors on                     , are enclosed herewith unless such financial projections have been previously furnished to Lender.

 The Company shall notify you promptly before the funding of the Loan if any of the matters to which I have certified above shall not be
true and correct on the Borrowing Date. 
  

					
		 	 Very truly yours,

		
		 	 EnteroMedics Inc.

			
		 	 Name:
	 	  

		 	 Title:*
	 	  

	*	Must be executed by Company’s Chief Financial Officer or other executive officer. 

  

 EXHIBIT “C” 
 COMPLIANCE CERTIFICATE 
 Venture Lending & Leasing [IV/V], Inc. 
 2010 North First Street, Suite 310 
 San Jose, CA 95131 
  

	 	Re:	EnteroMedics Inc. 

 Ladies and Gentlemen: 
 Reference is made to the Loan and Security Agreement dated as of May     , 2007 (as amended, restated and supplemented from
time to time, the “Loan Agreement”, the capitalized terms used herein as defined therein), between Venture Lending & Leasing [IV/V], Inc. and EnteroMedics Inc. (the “Company”). 
 The undersigned authorized representative of the Company hereby certifies that in accordance with the terms and conditions of the Loan Agreement,
(i) no Event of Default has occurred and is continuing as of the date hereof, and (ii) the Company is in complete compliance for the financial reporting period ending
                     with all required financial reporting and financial tests under the Loan Agreement, except as noted below. Attached
herewith are the required documents supporting the foregoing certification. The undersigned further certifies that the accompanying financial statements have been prepared in accordance with Generally Accepted Accounting Principles (except for the
omission of footnotes on the unaudited Interim Financial Statements), and are consistent from one period to the next, except as explained below. 
 Indicate compliance status by circling Yes/No under “Complies” 
  

					
	 REPORTING REQUIREMENT
	  	 REQUIRED
	  	 COMPLIES

	 Interim Financial Statements
	  	Monthly within 30 days	  	YES / NO
	 Audited Financial Statements
	  	FYE within 180 days	  	YES / NO

 Ratio of Unrestricted Cash to Four Months’ Expenses: 
 (i) Unrestricted Cash as of             :
                                        
             
 (ii) Four Months’ Expenses for the 4 months ended
            :              
 (iii) Ratio of (i) to (ii):              [if less than 1:1, then Lien against IP springs] 
 Date of most recent Board-approved 
 budget/plan                                  
  

			
	 Any change in budget/plan since version most recently delivered to Lender
	 	YES* / NO

	*	if “YES” then please attach 

 ACCOUNT CONTROL AGREEMENTS

 Pursuant to Section 6.11 of the Loan Agreement, Company represents and warrants that: (i) as of the date hereof, it maintains only those
Deposit Accounts and investment/securities accounts set forth below; and (ii) a control agreement has been executed and delivered to Lender with respect to each such account [Note: If the Company has established any new account(s) since the
date of the last compliance certificate, please so indicate]. 
  

 Deposit Accounts 
  

											
	 	  	 Name of Institution
	  	 Account Number
	  	 Control Agt.
 In place?
	  	 Complies
	  	 New
 Account

	 1.)
	  	  
	  	  
	  	YES / NO	  	YES / NO	  	YES / NO
						
	 2.)
	  	  
	  	  
	  	YES / NO	  	YES / NO	  	YES / NO
						
	 3.)
	  	  
	  	  
	  	YES / NO	  	YES / NO	  	YES / NO
						
	 4.)
	  	  
	  	  
	  	YES / NO	  	YES / NO	  	YES / NO
	
	Investment Accounts
						
	 	  	 Name of Institution
	  	 Account Number
	  	 Control Agt.
 In place?
	  	 Complies
	  	 New
 Account

	 1.)
	  	  
	  	  
	  	YES / NO	  	YES / NO	  	YES / NO
						
	 2.)
	  	  
	  	  
	  	YES / NO	  	YES / NO	  	YES / NO
						
	 3.)
	  	  
	  	  
	  	YES / NO	  	YES / NO	  	YES / NO
						
	 4.)
	  	  
	  	  
	  	YES / NO	  	YES / NO	  	YES / NO

 EXPLANATIONS 
  

	
	  

	  

	  

	  

 Please provide the following information regarding the Company’s financing: 
 Date of Last Round Raised:                      
  

			
	Has there been any new financing since the last Compliance Certificate submitted?	  	YES /NO

 If “YES” please complete information below and attach a copy of the Capitalization
Table 
 Date Closed:                     
Series:                      Per Share Price: $             
 Amount Raised:          Post Money Valuation:          
  

			
	Any stock splits since date of last report?	  	YES /NO

 If yes, please provide any information on stock splits which would affect valuation: 

	
	  

  

			
	 Any dividends since date of last report?
	  	YES / NO

 If yes, please provide any information on dividends which would affect valuation: 
  

	
	  

 Any unusual terms? (ie. Anti-dilution, multiple preference, etc.) 
 If yes, please explain: 
  

	
	  

  

					
		 	 Very truly yours,

		
		 	 ENTEROMEDICS INC.

			
		 	 Name:
	 	  

		 	 Title:*
	 	  

	*	Must be executed by Company’s Financial Officer or other executive officer. 

  

 EXHIBIT “D” 
 FORM OF INTELLECTUAL PROPERTY SECURITY AGREEMENT 
  

 EXHIBIT “E” 
 FORM OF WARRANT 
  

 EXHIBIT “F” 
 FORM OF LEGAL OPINION

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