Document:

EX-4.2

 EXHIBIT 4.2 

DESCRIPTION OF SECURITIES REGISTERED UNDER SECTION 12 OF THE EXCHANGE ACT 

References to “Translate Bio” and the “Company” herein are, unless the context otherwise indicates, only to Translate Bio, Inc.
and not to any of its subsidiaries. 
 General 

The following description of the Company’s capital stock is a summary and does not purport to be complete. It is subject to and
qualified in its entirety by reference to the Company’s Restated Certificate of Incorporation (the “Certificate of Incorporation”) and the Company’s Amended and Restated Bylaws (the “Bylaws”), each of which is
incorporated by reference as an exhibit to the Annual Report on Form 10-K of which this Exhibit 4.[X] is a part. 

The Company’s authorized capital stock consists of 200,000,000 shares of common stock, $0.001 par value per share (the “Common
Stock”), and 10,000,000 shares of preferred stock, $0.001 par value per share (the “Preferred Stock”). 
 Common Stock 

Holders of Common Stock are entitled to one vote for each share held on all matters submitted to a vote of stockholders and do not have
cumulative voting rights. Each election of directors by the Company’s stockholders will be determined by a plurality of the votes cast by the stockholders entitled to vote on the election, and all other questions will be decided by a majority
of the votes cast by stockholders entitled to vote thereon. Holders of Common Stock are entitled to receive proportionately any dividends as may be declared by the Company’s board of directors, subject to any preferential dividend rights of
outstanding Preferred Stock. 
 In the event of the Company’s liquidation or dissolution, the holders of Common Stock are entitled to
receive proportionately all assets available for distribution to stockholders after the payment of all debts and other liabilities and subject to the prior rights of any of the Company’s outstanding Preferred Stock. Holders of Common Stock have
no preemptive, subscription, redemption or conversion rights. The rights, preferences and privileges of holders of Common Stock are subject to and may be adversely affected by the rights of the holders of shares of any series of Preferred Stock that
may be designated and issued in the future. 
 Preferred Stock 

Under the terms of the Certificate of Incorporation, the Company’s board of directors is authorized to issue shares of Preferred Stock in
one or more series without stockholder approval. The board of directors has the discretion to determine the rights, preferences, privileges and restrictions, including voting rights, dividend rights, conversion rights, redemption privileges and
liquidation preferences, of each series of Preferred Stock. 
 The purpose of authorizing the Company’s board of directors to issue
Preferred Stock and determine its rights and preferences is to eliminate delays associated with a stockholder vote on specific issuances. The issuance of Preferred Stock, while providing flexibility in connection with possible acquisitions, future
financings and other corporate purposes, could have the effect of making it more difficult for a third party to acquire, or could discourage a third party from seeking to acquire, a majority of the Company’s outstanding voting stock. 

 Delaware Anti-Takeover Law and Certain Charter and Bylaw Provisions 

Delaware Law 
 The Company
is subject to Section 203 of the Delaware General Corporation Law (the “DGCL”). Subject to certain exceptions, Section 203 prevents a publicly held Delaware corporation from engaging in a “business combination” with any
“interested stockholder” for three years following the date that the person became an interested stockholder, unless either the interested stockholder attained such status with the approval of the Company’s board of directors, the
business combination is approved by the Company’s board of directors and stockholders in a prescribed manner or the interested stockholder acquired at least 85% of the Company’s outstanding voting stock in the transaction in which it
became an interested stockholder. A “business combination” includes, among other things, a merger or consolidation involving the Company and the “interested stockholder” and the sale of more than 10% of the Company’s assets.
In general, an “interested stockholder” is any entity or person beneficially owning 15% or more of the Company’s outstanding voting stock and any entity or person affiliated with or controlling or controlled by such entity or person.

 Staggered Board; Removal of Directors 

The Certificate of Incorporation and Bylaws divide the Company’s board of directors into three classes with
staggered three-year terms. In addition, the Certificate of Incorporation and Bylaws provide that the Company’s directors may be removed only for cause and only by the affirmative vote of the holders of at least 75% of the
Company’s shares of capital stock present in person or by proxy and entitled to vote. Under the Certificate of Incorporation and Bylaws, any vacancy on the board of directors, including a vacancy resulting from an enlargement of the board of
directors, may be filled only by vote of a majority of the directors then in office. Furthermore, the Certificate of Incorporation provides that the authorized number of directors may be changed only by resolution of the Company’s board of
directors. The classification of the board of directors and the limitations on the ability of the stockholders to remove directors, change the authorized number of directors and fill vacancies could make it more difficult for a third party to
acquire, or discourage a third party from seeking to acquire, control of the Company. 
 Stockholder Action; Special Meeting of
Stockholders; Advance Notice Requirements for Stockholder Proposals and Director Nominations 
 The Certificate of Incorporation and
Bylaws provide that any action required or permitted to be taken by the stockholders at an annual meeting or special meeting of stockholders may only be taken if it is properly brought before such meeting and may not be taken by written action in
lieu of a meeting. The Certificate of Incorporation and Bylaws also provide that, special meetings of the stockholders can only be called by the board of directors. In addition, the Bylaws establish an advance notice procedure for stockholder
proposals to be brought before an annual meeting of stockholders, including proposed nominations of candidates for election to the board of directors. Stockholders at an annual meeting may only consider proposals or nominations specified in the
notice of meeting or brought before the meeting by or at the direction of the board of directors, or by a stockholder of record on the record date for the meeting who is entitled to vote at the meeting and who has delivered timely written notice in
proper form to the Company’s secretary of the stockholder’s intention to bring such business before the meeting. These provisions could have the effect of delaying until the next stockholder meeting stockholder actions that are favored by
the holders of a majority of the outstanding voting securities. These provisions also could discourage a third party from making a tender offer for the Company’s Common Stock because even if the third party acquired a majority of the
Company’s outstanding voting stock, it would be able to take action as a stockholder, such as electing new directors or approving a merger, only at a duly called stockholders meeting and not by written consent. 

Super-Majority Voting 

The DGCL provides generally that the affirmative vote of a majority of the shares entitled to vote on any matter is required to amend a
corporation’s certificate of incorporation or bylaws unless a corporation’s certificate of incorporation or bylaws, as the case may be, requires a greater percentage. The Company’s Bylaws

 
may be amended or repealed by a majority vote of the board of directors or the affirmative vote of the holders of at least 75% of the votes that all stockholders would be entitled to cast in any
annual election of directors. In addition, the affirmative vote of the holders of at least 75% of the votes that all stockholders would be entitled to cast in any election of directors is required to amend or repeal or to adopt any provisions
inconsistent with any of the provisions of the Certificate of Incorporation described above. 
 Exclusive Forum Selection 

The Certificate of Incorporation provides that, unless the Company consents in writing to the selection of an alternative forum, the Court of
Chancery of the State of Delaware (or, if the Court of Chancery of the State of Delaware does not have jurisdiction, the federal district court for the District of Delaware) shall be the sole and exclusive forum for (1) any derivative action or
proceeding brought on behalf of the Company, (2) any action asserting a claim of breach of a fiduciary duty owed by any of the directors, officers, employees or stockholders to the Company or its stockholders, (3) any action asserting a
claim arising pursuant to any provision of the DGCL or as to which the DGCL confers jurisdiction on the Court of Chancery of the State of Delaware, or (4) any action asserting a claim arising pursuant to any provision of the Certificate of
Incorporation or Bylaws (in each case, as they may be amended from time to time) or governed by the internal affairs doctrine. We do not expect this choice of forum provision will apply to suits brought to enforce a duty or liability created by the
Securities Act of 1933, as amended, the Exchange Act of 1934, as amended, or any other claim for which federal courts have exclusive jurisdiction. Although the Certificate of Incorporation contains the choice of forum provision described above, it
is possible that a court could rule that such a provision is inapplicable for a particular claim or action or that such provision is unenforceable.EX-10.12

			
	  
 

	  	 29 Hartwell Avenue
 Lexington, MA 02421

P (617) 945 7361

 EXHIBIT 10.12 

March 11, 2020 
 Ronald C. Renaud, Jr. 

 

	Re:	 Amendment to Employment Agreement 

Dear Ron: 
 Reference is made to that certain
Employment Agreement dated October 31, 2014 between Translate Bio, Inc. (formerly known as RaNA Therapeutics, LLC) (the “Company”), and you regarding the terms of your employment with the Company (the “Employment
Agreement”). This letter agreement (the “Amendment”) confirms the agreement between the Company and you regarding an amendment to the Employment Agreement. Please note that you must sign and return this Amendment
within seven (7) days of receipt to avail yourself of its terms. 
  

	1.	 The following language shall be inserted as paragraphs 14, 15 and 16 of the Offer Letter.

 “14. Parachute Treatment. Notwithstanding any other provision of this Agreement to the contrary, if payments
and benefits provided for under this Agreement together with any payments or benefits under any other agreement or arrangement between the Company or any of its affiliates and you are considered “excess parachute payments” under
Section 280G of the Internal Revenue Code (the “Code”), then such excess parachute payments plus any other payments made by the Company and its affiliates that you are entitled to receive that are considered excess parachute
payments shall be limited to the greatest amount that may be paid to you under Section 280G of the Code without causing any loss of deduction to the Company under such Code Section, but only if, by reason of such reduction, the “Net After
Tax Benefit” (as defined below) to you shall exceed the net after tax benefit if such reduction was not made. “Net After Tax Benefit” for purposes of this Agreement shall mean the sum of (i) the total amounts payable to
you that would constitute an “excess parachute payment” within the meaning of Section 280G of the Code, less (ii) the amount of federal, state and other income taxes payable with respect to the foregoing calculated at the maximum
marginal tax rate for each year in which the foregoing shall be paid to you (based upon the rate in effect for such year as set forth in the Code at the time of termination of your employment or the change in control), less (iii) the amount of
excise taxes imposed with respect to the payments and benefits described above by Section 4999 of the Code. The determination of whether payments would be considered excess parachute payments and the calculation of all the amounts referred to
in this section shall be made reasonably and in good faith by the parties, provided, that if the parties cannot agree, then such determination (and supporting calculations) shall be made by attorneys, accountants, or an executive compensation
consulting firm each as selected by the Company at the expense of the Company (the “280G Service Providers”). Any determination by the 280G Service Providers made in good faith shall be binding upon the Company and you. 

  
 

 

 15. Tax Acknowledgement. All forms of compensation referred to in this
Agreement are subject to all applicable federal, state and/or local withholding and/or payroll taxes, and the Company may withhold from any amounts payable to you in order to comply with such withholding obligations and you shall be responsible for
all applicable taxes with respect to such compensation. You hereby acknowledge that the Company does not have a duty to design its compensation policies in a manner that minimizes your tax liabilities, and you will not make any claim against the
Company or its board of directors related to tax liabilities arising from your compensation. You further acknowledge that you are not relying upon the advice or representation of the Company with respect to the tax treatment of any of the
compensation set forth in this Agreement. 
 16. 409A Compliance. This Agreement is intended to provide payments that are
exempt from or compliant with Section 409A, and should be interpreted consistent with that intent. The attached exhibit entitled “Payments Subject to Section 409A” is hereby appended to the Agreement as Attachment A and, if
applicable, replaces any previous such attachment concerning the same subject matter.” 
  

	2.	 This Amendment shall be governed, construed and interpreted in accordance with the laws of the
Commonwealth of Massachusetts, without giving effect to any principles of conflicts of law that would require the application of laws of any other jurisdiction. 

 

	3.	 Except as specifically provided herein, the Employment Agreement remains in full force and effect, and
is not modified or amended hereby. 

  

	4.	 This Amendment may be executed in counterparts by each of the signatories, each of which will be
considered an original, but all of which together will constitute one agreement. 

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left blank] 

  
 2 

 We look forward to receiving a response from you within seven (7) days acknowledging,
by signing below, that you have accepted the terms of this Amendment to your Employment Agreement. 
  

			
	Very truly yours,
	
	TRANSLATE BIO, INC.
		
	By:	 	/s/ Daniel Lynch
		 	Daniel Lynch

 I have read and accept the terms of this Amendment to my Employment Agreement. 

Accepted and Agreed as of March 11, 2020 
  

			
		 	 /s/ Ronald C. Renaud, Jr.

		 	Ronald C. Renaud, Jr.

  
 3 

 Attachment A 

Payments Subject to Section 409A 
 1.
Subject to this Attachment A, any severance payments that may be due under the letter agreement shall begin only upon the date of your “separation from service” (determined as set forth below) which occurs on or after the termination of
your employment. The following rules shall apply with respect to distribution of the severance payments, if any, to be provided to you under the letter agreement, as applicable: 

 

	 	a.	 It is intended that each installment of the severance payments under the letter agreement shall be treated as a
separate “payment” for purposes of Section 409A of the Internal Revenue Code of 1986, as amended (“Section 409A”). Neither the Company nor you shall have the right to accelerate or defer the delivery of any such
payments except to the extent specifically permitted or required by Section 409A. 

  

	 	b.	 If, as of the date of your “separation from service” from the Company, you are not a “specified
employee” (within the meaning of Section 409A), then each installment of the severance payments shall be made on the dates and terms set forth in the letter agreement. 

 

	 	c.	 If, as of the date of your “separation from service” from the Company, you are a “specified
employee” (within the meaning of Section 409A), then: 

  

	 	i.	 Each installment of the severance payments due under the letter agreement that is paid within the short-term
deferral period (as defined under Section 409A) shall be treated as a short-term deferral within the meaning of Treasury Regulation Section l.409A-l(b)(4) to the maximum extent permissible under
Section 409A and shall be paid on the dates and terms set forth in the letter agreement; and 

  

	 	ii.	 Each installment of the severance payments due under the letter agreement that is not described in this
Attachment A, Section I (c)(i) and that would, absent this subsection, be paid within the six-month period following your “separation from service” from the Company shall not be paid until the date
that is six months and one day after such separation from service (or, if earlier, your death), with any such installments that are required to be delayed being accumulated during the six-month period and paid
in a lump sum on the date that is six months and one day following your separation from service and any subsequent installments, if any, being paid in accordance with the dates and terms set forth herein; provided, however, that the preceding
provisions of this sentence shall not apply to any installment of payments if and to the maximum extent that such installment is deemed to be paid under a separation pay plan that does not provide for a deferral of compensation by reason of the
application of Treasury Regulation 1.409A-1(b)(9)(iii) (relating to separation pay upon an involuntary separation from service). Any installments that qualify for the exception under Treasury Regulation
Section 1.409A-1(b)(9)(iii) must be paid no later than the last day of your second taxable year following the taxable year in which the separation from service occurs. 

2. The determination of whether and when your separation from service from the Company has occurred shall be made and in a manner consistent
with, and based on the presumptions set forth in, Treasury Regulation Section 1.409A-1 (h). Solely for purposes of this Attachment A, Section 2, “Company” shall include all persons with
whom the Company would be considered a single employer under Section 414(b) and 414( c) of the Internal Revenue Code of 1986, as amended. 

3. The Company makes no representation or warranty and shall have no liability to you or to any other person if any of the provisions of the
letter agreement (including this Attachment) are determined to constitute deferred compensation subject to Section 409A but that do not satisfy an exemption from, or the conditions of, that section.

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