Document:

Exhibit 10.27

NINTH AMENDMENT

to

LEASE BETWEEN

EMERY STATION OFFICE II, LLC (LANDLORD)

And

KINEMED, INC. (TENANT)

 

That certain Lease dated May 5, 2002 by and between Emery Station
Office II, LLC (successor-in-interest to Emery Station Associates II, LLC), as Landlord, and KineMed, Inc., as Tenant, (the “Original
Lease”) as such was amended via First Amendment executed on June 27, 2003 (the “First Amendment”), via Second
Amendment whose effective date was December 1, 2004 (the “Second Amendment”), via Revised Third Amendment whose effective
date was February 28, 2005 (the “Third Amendment”), via Revised Fourth Amendment whose effective date was March 15,
2005 (the “Fourth Amendment”), via Fifth Amendment whose effective date was August 31, 2008 (the “Fifth Amendment”),
whose Sixth Amendment with a contemplated effective date of December I, 2008 (the “Sixth Amendment”) was never fully
executed by mutual agreement of the parties, via Seventh Amendment whose effective date was May 1, 2009 (the “Seventh Amendment”)
and via Eighth Amendment dated July 31, 2010 (the “Eighth Amendment”), is hereby further amended as follows (the Original
Lease as amended previously by the First, Second, Third, Fourth, Fifth, Seventh and Eighth Amendments, and now by this Ninth Amendment,
are collectively referred to as the “Lease”). The effective date of this Ninth Amendment shall be February 10, 2011
(the “Ninth Amendment Effective Date”).

 

		I.	Landlord and Tenant hereby agree to extend the expiry of the Lease Term by twelve (12) months to
become July 31, 2013. Monthly Base Rent shall continue to increase three percent (3%) annually, effective every June 30 as defined
in Section 3 of the Seventh Amendment.

 

		II.	Landlord has invoked its Vivarium Relocation Right described in the Eighth Amendment to require
Tenant's animal holding and procedure room functions to be relocated in full to the EmeryStation East Building located at 5885
Hollis Street. Tenant has fully accepted the New Vivarium Space in the EmeryStation East building. Tenant agrees to complete its
ESE Relocation in full on or before February 26, 2011. Failure to do so shall constitute a Default under the Lease.

 

		III.	Pursuant to the terms of the Eighth Amendment, Landlord elected Landlord's Existing Vivarium Option
2 such that the Existing Vivarium Space remains a portion of Tenant's Premises, which Premises measures 15,454 rentable square
feet prior to any reductions in size described in Section IV below.

 

		IV.	In consideration of Tenant's agreement to extend the Lease term pursuant to Section I above, Landlord
and Tenant agree reduce Tenant's Premises as follows:

 

    	 

    	 

    

 

		a)	On or before 5 p.m. March 27, 2011 (the “Suite 460 Give-Back Date”), Tenant shall vacate
the 2,559 rentable square foot Suite 460 as identified on Exhibit A attached hereto, surrendering the space back to Landlord on
or before that date in broom-clean condition including a full decontamination and decommissioning thereof by a qualified third-party
firm experienced in such work, such decontamination and decommissioning being evidenced by a written report supplied to Landlord
(the “Tenant Suite 460 Give-Back”). Tenant's failure to accomplish Tenant's Suite 460 Give-Back on or before the Suite
460 Give-Back Date shall constitute a Default under the Lease. So long as Tenant has accomplished Tenant's Suite 460 Give-Back
by the Suite 460 Give-Back Date, effective March 28, 2011 Tenant's Premises shall be reduced by 2,559 rentable square feet, its
Monthly Base Rent shall be reduced to $38,118.89, and Tenant's Share of Operating Expenses and Taxes shall be adjusted pro-rata
to reflect the deletion of Suite 460 from the overall Premises.
	 	 	 

		b)	On or before 5 p.m. March 27, 2011 (the “Suite 400 Give-Back Date”), Tenant shall vacate
the 2,910 rentable square foot Suite 400 as identified on Exhibit A attached hereto, surrendering the space back to Landlord on
or before that date in broom-clean condition (the “Tenant Suite 400 Give-Back”). Tenant's failure to accomplish
Tenant's Suite 400 Give-Back on or before the Suite 400 Give-Back Date shall constitute a Default under the Lease. So long as Tenant
has accomplished Tenant's Suite 400 Give-Back by the Suite 400 Give-Back Date, effective March 28, 2011 Tenant's Premises shall
be further reduced, by 2,910 rentable square feet, its Monthly Base Rent shall be further reduced, to $29,516.64, and Tenant's
Share of Operating Expenses and Taxes shall be adjusted pro-rata to reflect the deletion of Suite 460 from the overall Premises.

 

		c)	Following both the Suite 400 and 460 Give-Backs, Tenant's Premises shall constitute 9,985 rentable
square feet and will be as described on Exhibit B hereof.

 

		V.	The Security Deposit under the Lease is and remains $63,949.83.

 

		VI.	Tenant hereby represents to Landlord that it has represented itself in this transaction and that
no brokerage commission will be payable to any tenant broker or representative as a result hereof.

 

		VII.	Except for those terms outlined herein, all other terms and conditions of the Lease, as amended,
and Work Letter shall apply.

 

    	 

    	 

    

 

In witness hereof, the parties have executed this Ninth Amendment.

 

	TENANT:	LANDLORD:
	 	 
	KineMed, Inc., a Delaware Corporation	Emery Station Office II LLC, a 
	 	California Limited Liability Company

 

	By	: /s/ David M. Fineman	 	By: 	/s/ Richard K. Robbins

 

	Print Name	: David Fineman	 	Print Name: 	Richard K. Robbins

 

	Its: 	President and CEO	 	Its:	 

 

	Dated: 2/15/11	Dated: 2/16/11

 

    	 

    	 

    

 

EXHIBIT A

 

    	 

    	 

    

 

 

    	 

    	 

    

 

EXHIBIT B

 

PREMISES AFTER SUITE 400 AND 460 GIVE-BACKSExhibit 10.28

TENTH AMENDMENT

to

LEASE BETWEEN

EMERY STATION OFFICE H, LLC (LANDLORD)

And

KINEMED, INC. (TENANT)

 

That certain Lease dated May 5, 2002 by and between Emery Station
Office II, LLC (successor-in-interest to Emery Station Associates H, LLC), as Landlord, and KineMed, Inc., as Tenant, (the “Original
Lease”) as such was amended via First Amendment executed on June 27, 2003 (the “First Amendment”), via Second
Amendment whose effective date was December 1, 2004 (the “Second Amendment”), via Revised Third Amendment whose effective
date was February 28, 2005 (the “Third Amendment”), via Revised Fourth Amendment whose effective date was March
15, 2005 (the “Fourth Amendment”), via Fifth Amendment whose effective date was August 31, 2008 (the “Fifth Amendment”),
whose Sixth Amendment with a contemplated effective date of December 1, 2008 (the “Sixth Amendment”) was never fully
executed by mutual agreement of the parties, via Seventh Amendment whose effective date was May 1, 2009 (the “Seventh Amendment”),
via Eighth Amendment dated July 31, 2010 (the “Eighth Amendment”) and via Ninth Amendment whose effective date was
February 10, 2011 (the “Ninth Amendment”), is hereby further amended by the terms of this Tenth Amendment (the “Tenth
Amendment). The Tenth Amendment shall have an Effective Date of April 1, 2013 (the “Tenth Amendment Effective Date”).
From and after the Tenth Amendment Effective Date, the Original Lease as amended by the First, Second, Third, Fourth, Fifth, Seventh,
Eighth and Ninth Amendments and now by this Tenth Amendment, shall collectively constitute and be referred to as the “Lease”
for all purposes thereunder.

 

		I.	Landlord and Tenant hereby agree to extend the expiry
of the Lease Term by fifty (50) months to become September 30, 2017 (the “Extended Lease Term”).

 

		II.	Up to and including July 31, 2013, Monthly Base Rent
shall be as called for in the Ninth Amendment. Effective August 1, 2013, Monthly Base Rent shall be as follows:

  

	PERIOD	 	MONTHLY BASE RENT	 
	8/1/13 - 8/31/13	 	$	0.00	 
	9/1/13 - 7/31/14	 	$	27,958.00	 
	8/1/14 - 7/31/15	 	$	28,796.74	 
	8/1/15 - 8/31/15	 	$	0.00	 
	9/1/15 - 7/31/16	 	$	29,660.64	 
	8/1/16 - 7/31/17	 	$	30,550.46	 
	8/1/17 - 9/30/17	 	$	31,466.98	 

 

		III.	Promptly following the mutual execution of this Tenth
Amendment, Landlord shall, at its sole cost and expense, make the following improvements to Tenant's Premises:

 

		·	Add a circuit breaker to the existing panel in KineMed's
LC/MS room (or at Landlord's sole option, install a new panel therefore, if needed), which circuit breaker will supply 200 amps
of 120-208 volt, 3-phase power.

 

    	 

    	 

    

 

		·	Install new Building Standard carpet, of a color reasonably
selected by Tenant, in all locations of the Premises where carpet currently exists. Tenant agrees and acknowledges that such installation
shall require Tenant's cooperation in temporarily relocating certain FF&E, etc. to facilitate Landlord's re-carpeting.

 

		IV.	Tenant hereby represents to Landlord that it has been
represented by Jonathan Tomasco of Cornish & Carey in this transaction and that other than to he no brokerage commission will
be payable to any tenant broker or representative as a result hereof.

 

		V.	Except for those terms outlined herein, all other terms
and conditions of the Lease, as amended, and Work Letter shall apply.

 

In witness hereof, the parties have executed this Tenth Amendment.

 

	TENANT:	 	LANDLORD:
	 	 	 
	KineMed, Inc., a Delaware Corporation	 	Emery Station Office II LLC, a 
	 	 	California Limited Liability Company
	 	 	 	 	 
	By: 	/s/ David M. Fineman	 	By: 	/s/ R. Robbins
	 	 	 	 	 
	Print Name: 	David M. Fineman	 	Print Name: 	Richard K. Robbins
	 	 	 	 	 
	Its: 	Pres & CEO	 	Its: 	Managing Member
	 	 	 	 	 
	Dated: 4/8/13	 	Dated: 4/26/13Exhibit 10.29

LEASE BETWEEN

E S EAST, LLC (LANDLORD)

And

KINEMED, INC. (TENANT)

EmeryStation East, 5885 Hollis Street

Emeryville, California

 

		A.	KineMed, Inc., a Delaware Corporation, (“Tenant”) is party to that certain lease (the “ES North Lease”)
for space in a project commonly referred to as EmeryStation North located at 5980 Horton Street in Emeryville, CA (“The ES
North Building”). The landlord in the ES North Lease is Emery Station Office II, LLC (“ES Office II”).

 

		B.	ES Office II is an affiliate of E S East, LLC (“Landlord”). Landlord owns a building commonly referred to as EmeryStation
East located at 5885 Hollis Street in Emeryville, CA (the “ES East Building”).

 

		C.	Pursuant to the terms of the Eighth Amendment to the ES North Lease, ES Office II has invoked its Vivarium Relocation Right
as described therein, whereby Tenant agrees to relocate its animal holding and procedure room functions and operations out of the
ES North Building and into the ES East Building (the “ESE Relocation”).

 

		D.	Pursuant to separate agreement entered into between ES Office II and Landlord, ES Office II has arranged for Landlord to enter
into this Lease with Tenant to facilitate Tenant's ESE Relocation.

 

		E.	Tenant hereby leases from Landlord, and Landlord leases to Tenant, Suite 375in the ES East Building (the “ES East Premises).
The ES East Premises measures 3,455 rentable square feet and is more fully described in Exhibit A-1 attached hereto.

 

		F.	For convenience, Landlord and Tenant wish to utilize all of the terms and conditions of the original ES North Lease (i.e. the
original Lease dated May 5, 2002, not modified by the First through Eighth Amendments that were subsequently made thereto) to govern
Tenant's lease of the ES East Premises, modified only by those additional terms outlined below. A copy of the ES North Lease is
attached hereto and all relevant terms and conditions thereof are incorporated herein by reference. The terms of the ES North Lease,
as modified by the terms below, shall together be referred to as the “ES East Lease” from and after October 20, 2010
(the “ES East Lease Effective Date”):

 

		1)	The “Landlord” under the ES East Lease shall be E S East, LLC, with the same notice addresses as for the landlord
under the E S North Lease.

 

		2)	The Date of the ES East Lease shall be October 20, 2010.

 

		3)	The “Building” under the ES East Lease shall be EmeryStation East; the “Address” of the Building is
5885 Hollis Street, Emeryville, CA.

 

		4)	The “Premises” under the ES East Lease shall be the ES East Premises, as more fully described on Exhibit A-1 attached
hereto.

 

		5)	Tenant shall accept the ES East Premises in its current as-is condition subject only to Landlord's obligation, at Landlord's
sole cost, to make the improvements thereto described in the drawings attached as Exhibit B-1 attached hereto (the “New Vivarium
TI Drawings”), the work therein referred to as the “New Vivarium TI”.

 

		6)	Tenant agrees to relocate its animal holding and procedure room operations out of the ES North Building and into the E S East
Premises no later than fifteen (15) days after Landlord's Substantial Completion of the New Vivarium TI.

 

    	 

    	 

    

 

		7)	The “Commencement Date” of the ES East Lease shall be the earlier to occur of: a) Tenant's opening of operations
in the ES East Premises, and b) fifteen (15) days after Landlord notifies Tenant it has achieved Substantial Completion of the
New Vivarium TI.

 

		8)	The “Expiration Date” of the ES East Lease shall be July 31, 2012. The “Lease Term” of the ES East
Lease shall be the period commencing on the Commencement Date and running to and including the Expiration Date.

 

		9)	Monthly Base Rent for the ES East Premises shall be as follows:

 

	PERIOD	 	MONTHLY BASE RENT	 
	Commencement Date to June 30, 2011	 	$	4,040.99	 
	July 1, 2011 to June 30, 2012	 	$	4,162.22	 
	July 1, 2012 to July 31, 2012	 	$	4,287.09	 

 

Notwithstanding the above, the first one hundred-eighty
(180) days of Monthly Base Rent following the Commencement Date shall be free ($0.00).

 

		10)	Tenant shall pay Tenant's Share of Operating Expenses and Taxes on the E S East Premises commencing on the Commencement Date
of the E S East Lease and throughout the Lease Term. Notwithstanding the rentable area of the E S East Premises and the total rentable
area of the E S East Building, Tenant's Share for the E S East premises shall be 0.82%, calculated based on the ratio Tenant's
former 1,367 rentable square foot vivarium in EmeryStation North bears to the 167,668 total rentable square footage of the EmeryStation
North Building, all as specified in the Eighth Amendment to the ES North Lease.

 

		11)	The Rentable Area of the E S East Premises is 3,455 square feet.

 

		12)	Tenant shall be entitled to one (I) unreserved parking space in the EmeryStation East Building at Landlord's standard quoted
rates.

 

		13)	The Security Deposit for the ES East Lease shall be: None.

 

		14)	The Suite Number of the E S East Premises is 375.

 

		15)	Parking under the ES East Lease shall be: None.

 

		16)	Brokers under the ES East Lease shall be: None.

 

		17)	The following sections of the ES North Lease shall not apply to the E S East Lease: a) Section 2.6 / Right of Expansion, and
b) Section 3.2 / Warrants.

 

    	 

    	 

    

 

In witness hereof, the parties have executed this Lease.

 

	TENANT:	 	LANDLORD:
	KineMed, Inc.	 	E S East, LLC
	 	 	 	 	 
	By: 	/s/ David M. Fineman	 	By: 	/s/ Richard K. Robbins
	 	 	 	 	 
	Print Name: 	David M. Fineman	 	Print Name: 	Richard K. Robbins

 

    	 

    	 

    

 

EXHIBIT A-1

ES EAST PREMISES

 

    	 

    	 

    

 

 

    	 

    	 

    

 

EXHIBIT B-1

NEW VIVARIUM T1 DRAWINGS

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