Document:

AMENDMENT NO. 3 TO INVESTOR REGISTRATION RIGHTS AGREEMENT

      THIS AMENDMENT NO. 3 (the "Amendment") is made and entered into effective
as of August 15, 2006, to that certain Investor Registration Rights Agreement
(the "Agreement") dated February 1, 2006 by and among GULF COAST OIL & GAS,
INC., a Nevada corporation (the "Company"), DAVID GONZALEZ, ESQ. (the "Escrow
Agent") and CORNELL CAPITAL PARTNERS, LP, CERTAIN WEALTH, LTD., and TAIB BANK,
B.S.C. (c) (collectively, the "Investors").

                                    Recitals:

      WHEREAS, the Company (the "Obligor") and the Investors entered into a
Securities Purchase Agreement ("Securities Purchase Agreement") dated February
1, 2006, pursuant to which the Obligor issued and sold to the Holder secured
convertible debentures (the "Debentures") in the principal sum of Two Million
Dollars ($2,000,000) and issued to Cornell Capital five-year warrants to
purchase 30,000,000 shares of common stock at the following exercise prices:
7,500,000 at $0.02 per share, 7,500,000 at $0.03 per share, 5,000,000 at $0.04
per share, 5,000,000 at $0.05 per share, and 5,000,000 at $0.06 per share (the
"Warrants"); and

      WHEREAS, in connection with the issuance of the Debentures, the Company
and the Investors entered into an Investor Registration Rights Agreement dated
February 1, 2006, as amended by Amendment No. 1 dated March 15, 2006, and
Amendment No. 2 dated March 31, 2006 ("Registration Rights Agreement"), pursuant
to which the Obligor agreed to it would file a Registration Statement
("Registration Statement") with the United States Securities and Exchange
Commission ("SEC") on or before April 7, 2006, and use its best efforts to have
the Registration Statement declared effective by the SEC not later than June 2,
2006; and

      WHEREAS, the Company filed the Registration Statement on April 7, 2006 but
the Registration Statement has not been declared effective by the SEC as of the
date hereof; and .

      WHEREAS, the parties hereto desire to amend the Agreement further to
extend certain deadlines contained therein; and

      WHEREAS, all terms in the Agreement, except as modified herein, and the
terms contained in the Transaction Documents, shall remain in full force and
effect.

      NOW, THEREFORE, in consideration of the premises and the mutual promises,
conditions and covenants contained herein and other good and valuable
consideration, receipt of which is hereby acknowledged, the parties hereto agree
as follows:

      1.    The foregoing recitals are hereby incorporated herein by reference
            and acknowledged as true and correct by the parties hereto.

      2.    Sections 2(a) and (b) of the Agreement are hereby amended and
            restated in their entirety to read as follows:
<PAGE>

                  "(a) Subject to the terms and conditions of this Agreement,
            the Company shall prepare and file, no later than April 7, 2006 (the
            "Scheduled Filing Deadline"), with the SEC a registration statement
            on Form S-1 or SB-2 (or, if the Company is then eligible, on Form
            S-3) under the Securities Act (the "Initial Registration Statement")
            for the resale by the Investors of the Registrable Securities, which
            includes at least 514,403,329 shares of Common Stock to be issued
            upon conversion of the Convertible Debentures and 30,000,000 shares
            of Common Stock to be issued upon exercise of the Warrants of even
            date herewith. The Company shall cause the Registration Statement to
            remain effective until the earlier of (i) all of the Registrable
            Securities have been sold or (ii) the date the Registrable
            Securities become eligible for sale without restriction under
            Section 144 (k) promulgated under the Securities Act of 1933, as
            amended. Prior to the filing of the Registration Statement with the
            SEC, the Company shall furnish a copy of the Initial Registration
            Statement to the Investors for their review and comment. The
            Investors shall furnish comments on the Initial Registration
            Statement to the Company within twenty-four (24) hours of the
            receipt thereof from the Company."

                  "(b) Effectiveness of the Initial Registration Statement. The
            Company shall use its best efforts (i) to have the Initial
            Registration Statement declared effective by the SEC no later than
            September 15, 2006 (the "Scheduled Effective Deadline") and (ii) to
            insure that the Initial Registration Statement and any subsequent
            Registration Statement remains in effect until all of the
            Registrable Securities have been sold, subject to the terms and
            conditions of this Agreement. It shall be an event of default
            hereunder if the Initial Registration Statement is not filed by the
            Scheduled Filing Deadline or declared effective by the SEC by the
            Scheduled Effective Deadline."

                     [SIGNATURE PAGES TO IMMEDIATELY FOLLOW]
<PAGE>

      IN WITNESS WHEREOF, the parties have signed and delivered this Amendment
Agreement on the date first set forth above.

GULF COAST OIL & GAS, INC.                CORNELL CAPITAL PARTNERS, LP

By:    /s/ Rahim Rayani                   By: Yorkville Advisors, LLC
Name:  Rahim Rayani                       Its: General Partner
Title: President & CEO

                                          By:    /s/ Mark A. Angelo
                                          Name:  Mark A. Angelo
                                          Title: Portfolio Manager

                                          CERTAIN WEALTH, LTD.

                                          By:    /s/ Larry Chaleff
                                          Name:  Larry Chaleff

                                          TAIB BANK, B.S.C. (c)

                                          By:    /s/ Larry Chaleff
                                          Name:  Larry ChaleffUnassociated Document

    EXHIBIT
      4.1

    
 

    SECOND
      AMENDMENT TO

    SHAREHOLDER
      PROTECTION RIGHTS AGREEMENT

     

    THIS
      SECOND AMENDMENT (this "Amendment"), effective as of May 31, 2006, and entered
      into as of August 25, 2006, is between MICROTEK MEDICAL HOLDINGS, INC., a
      Georgia corporation (the "Company"), and SUNTRUST BANK, as Rights Agent (the
      "Rights Agent").

    

    W
      I T N E S S E T H:

    

    WHEREAS,
      in connection with that certain Shareholder Protection Rights Agreement (the
      "Agreement") dated as of December 20, 1996, between the Company and the Rights
      Agent, as amended, the Board of Directors of the Company authorized and declared
      a dividend of one Right in respect of each share of Common Stock held of record
      as of the close of business on December 31, 1996; and

    

    WHEREAS,
      the Board of Directors of the Company deems it advisable and in the best
      interests of the Company and its shareholders to amend the Agreement in
      accordance with Section 5.4 of the Agreement;

    

    NOW,
      THEREFORE, in consideration of the premises and the respective agreements set
      forth herein, the parties hereby agree as follows:

    

    1. Defined
      Terms.
      Initially capitalized terms used in this Amendment which are not otherwise
      defined herein are used with the same meaning ascribed to such terms in the
      Agreement.

     

    2. Amendments.
      

    

    (a) Section
      4.4 is amended by deleting the current text appearing therein, and inserting
      in
      lieu thereof the following:

    

    The
      Rights Agent may resign and be discharged from its duties under this Agreement
      upon 60 days' notice (or such lesser notice as is acceptable to the Company)
      in
      writing mailed to the Company and to each transfer agent of Common Stock by
      registered or certified mail, and (if such resignation occurs following the
      Separation Time) to the holders of the Rights in accordance with Section 5.9.
      The Company may remove the Rights Agent upon 30 days' notice in writing, mailed
      to the Rights Agent and to each transfer agent of the Common Stock by registered
      or certified mail, and (if such removal occurs following the Separation Time)
      to
      the holders of the Rights in accordance with Section 5.9. If the Rights Agent
      should resign or be removed or otherwise become incapable of acting, the Company
      will appoint a successor to the Rights Agent. If the Company fails to make
      such
      appointment within a period of 30 days after such removal or after it has been
      notified in writing of such resignation or

    
      
         

      

      
         

        
          

        

      

      
         

        
        

      

    

    incapacity
      by the resigning or incapacitated Rights Agent or by the holder of any Rights
      (which holder shall, with such notice, submit such holder's Rights Certificate
      for inspection by the Company), then the holder of any Rights may apply to
      any
      court of competent jurisdiction for the appointment of a new Rights Agent.
      Any
      successor Rights Agent, whether appointed by the Company or by such a court,
      shall be a corporation or other business organization (or, with the Company’s
      prior approval, an affiliate of such a corporation or other business
      organization) organized and doing business under the laws of the United States
      or of any state of the United States, in good standing, which is authorized
      under such laws to exercise the powers of the Rights Agent contemplated by
      this
      Agreement and is subject to supervision or examination by federal or state
      authority and which has at the time of its appointment as Rights Agent a
      combined capital and surplus of at least $50,000,000. After appointment, the
      successor Rights Agent will be vested with the same powers, rights, duties
      and
      responsibilities as if it had been originally named as Rights Agent without
      further act or deed; but the predecessor Rights Agent shall deliver and transfer
      to the successor Rights Agent any property at the time held by it hereunder,
      and
      execute and delivery any further assurance, conveyance, act or deed necessary
      for the purpose. Not later than the effective date of any such appointment,
      the
      Company will file notice thereof in writing with the predecessor Rights Agent
      and each transfer agent of the Common Stock, and (if such effective date follows
      this Separation Time) mail a notice thereof in writing to the holders of the
      Rights. Failure to give any notice provided for in this Section 4.4, however,
      or
      any defect therein, shall not affect the legality or validity of the resignation
      or removal of the Rights Agent or the appointment of the successor Rights Agent,
      as the case may be.

    

    3. Change
      in Rights Agent.
      In
      connection with the change of the Company’s transfer agent from SunTrust Bank
      (“SunTrust”) to Computershare Investor Services, LLC, a Delaware limited
      liability company (“Computershare”), SunTrust hereby resigns as “Rights Agent”
effective as of the date of this Amendment, and the Company accepts and consents
      to such resignation. The Company appoints Computershare as successor Rights
      Agent, and Computershare hereby accepts such appointment and agrees to the
      terms
      of the Agreement. After the date of this Amendment, notices to the Rights Agent
      under the Agreement shall be delivered to:

    

    Computershare
      Investor Services, LLC

    250
      Royall Street

    Canton,
      Massachusetts 02021

    Attention:
      __________________________    

     

     

    
      
         

      

      
        2

        
          

        

      

      
         

      

    

    4. Counterparts.
      This
      Amendment may be executed in any one or more counterparts, each of which shall
      be deemed an original and all of which shall together constitute the same
      Amendment.

    

    5. Ratification.
      Except
      as modified and amended as set forth herein, the Agreement is hereby adopted,
      ratified and confirmed without further modification or amendment.

    

    IN
      WITNESS WHEREOF, the parties hereto have caused this Agreement to be duly
      executed as of the date first above written.

    

    MICROTEK
      MEDICAL HOLDINGS, INC.

    

    

    By: 
      ____________________________________     

    Name: __________________________________      

    Title:
      ___________________________________     

    

    

    

    SUNTRUST
      BANK

    

    

    By:
      ____________________________________

    Name:
      __________________________________

    Title:
      ___________________________________

    

    IN
      WITNESS WHEREOF, Computershare has executed this Amendment to indicate its
      acceptance of the duties of Rights Agent under the Agreement.

    

    COMPUTERSHARE
      INVESTOR SERVICES, LLC

    

    

    By:
      _____________________________________

    Name:
      ___________________________________

    Title:
      ____________________________________

     

     

    
      
         

      

      
        3

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