Document:

EX-10.4

 Exhibit 10.4 

RAIN THERAPEUTICS INC. 

2021 EMPLOYEE STOCK PURCHASE PLAN 
  

	1.	 Purpose 

The purpose of this Rain Therapeutics Inc. 2021 Employee Stock Purchase Plan (the “Plan”) is to provide employees of the Company and
its Designated Subsidiaries with an opportunity to purchase Common Stock through accumulated Contributions. The Company’s intention is to have Plan qualify as an “employee stock purchase plan” under Section 423 of the Code. The
provisions of the Plan, accordingly, will be construed so as to extend and limit Plan participation in a uniform and nondiscriminatory basis consistent with the requirements of Section 423 of the Code. 

 

	2.	 Definitions. 

(a)    “Administrator” means the Compensation Committee of the Board (or any successor committee)
or such other committee as designated by the Board to administer the Plan under Section 14. 

(b)    “Applicable Laws” means the requirements relating to the administration of equity-based
awards under U.S. state corporate laws, U.S. federal and state securities laws, the Code, any stock exchange or quotation system on which the Common Stock is listed or quoted and the applicable laws of any foreign country or jurisdiction where
options are, or will be, granted under the Plan. 
 (c)    “Board” means the Board of Directors
of the Company. 
 (d)    “Code” means the Internal Revenue Code of 1986, as amended from time
to time, and the rulings and regulations issued thereunder. 
 (e)    “Common Stock” means the
voting common stock of the Company, $0.001 par value per share. 
 (f)    “Company” means Rain
Therapeutics Inc., a Delaware corporation, and any successor corporation. 

(g)    “Compensation” means an Eligible Employee’s base salary or base hourly rate of pay
before deduction for any salary deferral contributions made by the Eligible Employee to any tax-qualified or nonqualified deferred compensation plan, but excluding commissions, overtime, incentive
compensation, bonuses and other forms of compensation. The Administrator, in its discretion, may, on a uniform and nondiscriminatory basis, establish a different definition of Compensation for an Offering Period. 

(h)    “Contributions” means the payroll deductions and any other additional payments that the
Administrator may permit to be made by a Participant to fund the exercise of options granted pursuant to the Plan. 

 (i)    “Designated Subsidiary” means any
Subsidiary that has been designated by the Administrator from time to time in its sole discretion as eligible to participate in the Plan. As of the date of adoption of the Plan, there are no Designated Subsidiaries. 

(j)    “Eligible Employee” means any person, including an officer, who is employed by the Company
or a Designated Subsidiary. For purposes of the Plan, the employment relationship shall be treated as continuing intact while the individual is on sick leave or other leave of absence approved by the Company. Where the period of leave exceeds 90
days and the individual’s right to reemployment is not guaranteed either by statute or by contract, the employment relationship shall be deemed to have terminated on the 91st day of such leave. “Eligible Employee” shall not include
any person who is a citizen or resident of a foreign jurisdiction if granting them an option under the Plan would violate the law of such jurisdiction, or if compliance with the laws of the jurisdiction would cause the Plan to violate
Section 423 of the Code. 
 (k)    “Employer” means the Company and each Designated
Subsidiary. 
 (l)    “Enrollment Date” means the first Trading Day of each Offering Period.

 (m)    “Exchange Act” means the Securities Exchange Act of 1934, as amended, including the
rules and regulations promulgated thereunder. 
 (n)    “Exercise Date” means the last Trading
Day of each Purchase Period. 
 (o)    “Fair Market Value” means as of any date, the value of
the Common Stock determined as follows: (i) if the Common Stock is listed on any established stock exchange, system or market, its Fair Market Value shall be the closing price for the Common Stock as quoted on such exchange, system or market as
reported in the Wall Street Journal or such other source as the Administrator deems reliable (or, if no sale of Common Stock is reported for such date, on the next preceding date on which any sale shall have been reported); and (ii) in the
absence of an established market for the Common Stock, the Fair Market Value thereof shall be determined in good faith by the Administrator. 

(p)    “New Exercise Date” means a new Exercise Date if the Administrator shortens any Offering
Period then in progress. 
 (q)    “Non-Voting Stock”
means the non-voting common stock of the Company, $0.001 par value per share. 

(r)    “Offering” means an offer under the Plan of an option that may be exercised during an
Offering Period as further described in Section 4. For purposes of the Plan, the Administrator may designate separate Offerings under the Plan (the terms of which need not be identical) in which Eligible Employees of one or
more Employers will participate, even if the dates of the applicable Offering Periods of each such Offering are identical and the provisions of the Plan will separately apply to each Offering. To the extent permitted by Treasury Regulation Section 1.423-2(a)(1), the terms of each Offering need not be identical provided that the terms of the Plan and an Offering together satisfy Treasury Regulation Sections
1.423-2(a)(2) and (a)(3). 

  
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 (s)    “Offering Periods” means the periods
established by the Administrator (not to exceed 27 months) during which an option granted pursuant to the Plan may be exercised. The duration and timing of Offering Periods may be changed pursuant to Sections 4, 18 and 19. The
first Offering Period shall commence on the date the Common Stock is first publicly traded and end on the last day of the Company’s eighth full fiscal quarter that follows the date on which such event occurs, and subsequent Offering Periods
shall be each 24-month period (eight full fiscal quarters) commencing after the first Offering Period ends. 

(t)    “Parent” means a “parent corporation,” whether now or hereafter existing, as
defined in Section 424(e) of the Code. 
 (u)    “Participant” means an Eligible Employee
who elects to participate in the Plan. 
 (v)    “Purchase Period” means the period during an
Offering Period which shares of Common Stock may be purchased on a Participant’s behalf in accordance with the terms of the Plan. During the first Offering Period, the Purchase Period will begin on the date the Common Stock is first publicly
traded and end on the last day of the second full fiscal quarter that follows the date on which such event occurs, and subsequent Purchase Periods shall be each six-month period (two full fiscal quarters)
commencing thereafter. Unless the Administrator determines otherwise, each Purchase Period will be a six-month period (two full fiscal quarters). 

(w)    “Purchase Price” means an amount equal to 85% of the Fair Market Value of a share of Common
Stock on the Enrollment Date or on the Exercise Date, whichever is lower; provided however, that the Purchase Price may be determined for subsequent Offering Periods by the Administrator subject to compliance with Section 423 of the Code (or
any other Applicable Law) or pursuant to Section 18. 

(x)    “Subsidiary” means a “subsidiary corporation,” whether now or hereafter existing,
as defined in Section 424(f) of the Code. 
 (y)    “Trading Day” means a day on which the
national stock exchange upon which the Common Stock is listed is open for trading or, if the Common Stock is not listed on an national stock exchange, a business day as determined by the Administrator in good faith. 

(z)    “Treasury Regulations” means the Treasury regulations of the Code. Reference to a specific
Treasury Regulation or Section of the Code shall include such Treasury Regulation or Section, any valid regulation promulgated under such Section, and any comparable provision of any future legislation or regulation amending, supplementing or
superseding such Section or regulation. 
  

	3.	 Eligibility. 

(a)    Offering Periods. Any Eligible Employee on a given Enrollment Date will be eligible to participate in the
Plan if he or she was employed by the Company for at least 30 days immediately preceding the Enrollment Date, subject to the requirements of Section 5; provided, however, that an Eligible Employee who commences employment
with the Company or a Designated Subsidiary following such 30-day period will be eligible to participate in the Plan at the beginning of the next Purchase Period to occur that is at least 30 days following the
commencement of his or her employment with the Company or a Designated Subsidiary. Eligible Employees who do not elect to participate in the Plan on a given Enrollment Date may elect to participate in the Plan at the beginning of any subsequent
Purchase Period, as determined by the Administrator. 

  
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 (b)    Non-U.S.
Employees. Employees who are citizens or residents of a non-U.S. jurisdiction (without regard to whether they also are citizens or residents of the United States or resident aliens (within the meaning of
Section 7701(b)(1)(A) of the Code)) may be excluded from participation in the Plan or an Offering if the participation of such employees is prohibited under the laws of the applicable jurisdiction or if complying with the laws of the applicable
jurisdiction would cause the Plan or an Offering to violate Section 423 of the Code. In addition, as provided in Section 14, the Administrator may establish one or more sub-plans of the Plan (which may, but are not
required to, comply with the requirements of Section 423 of the Code) to provide benefits to employees of Designated Subsidiaries located outside the United States in a manner that complies with local law. Any such sub-plan will be a component
of the Plan and will not be a separate plan. 
 (c)    Limitations. Any provisions of the Plan to the contrary
notwithstanding, no Eligible Employee will be granted an option under the Plan (i) to the extent that, immediately after the grant, such Eligible Employee (or any other person whose stock would be attributed to such Eligible Employee pursuant
to Section 424(d) of the Code) would own capital stock of the Company or any Parent or Subsidiary of the Company and/or hold outstanding options to purchase such stock possessing 5% or more of the total combined voting power or value of all
classes of the capital stock of the Company or of any Parent or Subsidiary of the Company, or (ii) to the extent that his or her rights to purchase stock under all employee stock purchase plans (as defined in Section 423 of the Code) of
the Company or any Parent or Subsidiary of the Company accrues at a rate, which exceeds $25,000 worth of stock (determined at the Fair Market Value of the stock at the time such option is granted) for each calendar year in which such option is
outstanding at any time, as determined in accordance with Section 423 of the Code and the regulations thereunder. 
  

	4.	 Offering Periods 

The Plan will be implemented by consecutive Offering Periods with new Offering Periods commencing at such times as determined by the Administrator. The
Administrator will have the power to change the duration of Offering Periods (including the commencement dates thereof) without stockholder approval. 
  

	5.	 Participation 

An Eligible Employee may participate in the Plan by (i) submitting to the Company’s Human Resources department (or its delegate), on or before a date
determined by the Administrator prior to an applicable Enrollment Date (or prior to the first day of the applicable Purchase Period, as provided under Section 3(a)), a properly completed subscription agreement authorizing
Contributions in the form provided by the Administrator for such purpose, or (ii) following an electronic or other enrollment procedure determined by the Administrator. 

  
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	6.	 Contributions 

(a)    At the time a Participant enrolls in the Plan pursuant to Section 5, such Participant will
elect to have payroll deductions made on each pay day or other Contributions (to the extent permitted by the Administrator) made during the Offering Period (or portion thereof) in an amount equal to at least 1% but not exceeding 15% of the
Compensation (or such other percentage of Compensation as determined by the Administrator in its sole discretion), which he or she receives on each pay day during the Offering Period; provided, however, that should a pay day occur on an Exercise
Date, a Participant will have any payroll deductions made on such day applied to his or her notional account under the subsequent Purchase Period or Offering Period. The minimum permissible projected Contribution by any Participant for an Offering
Period shall be $500. The Administrator, in its sole discretion, may permit all Participants in a specified Offering to contribute amounts to the Plan through payment by cash, check or other means set forth in the subscription agreement prior to
each Exercise Date of each Purchase Period. A Participant’s subscription agreement will remain in effect for successive Offering Periods unless terminated as provided in Section 10. 

(b)    Payroll deductions for a Participant will commence on the first pay day following the Enrollment Date (or such
later date on which a Participant enrolls in the Plan pursuant to Section 5) and will end on the last pay day prior to the Exercise Date of such Purchase Period to which such authorization is applicable, unless sooner
terminated by the Participant as provided in Section 10; provided, however, that with respect to the first Offering Period, payroll deduction for a Participant will not commence until such time as determined by the
Administrator. 
 (c)    All Contributions made for a Participant will be credited to his or her notional account under
the Plan and payroll deductions will be made in whole percentages only. Except to the extent permitted by the Administrator pursuant to Section 6(a), a Participant may not make any additional payments into such notional
account. 
 (d)    A Participant may discontinue his or her participation in the Plan as provided in
Section 10. Participants shall not be permitted to increase or to otherwise decrease their rates of Contributions during a Purchase Period unless otherwise determined by the Administrator in its sole discretion; provided,
however, that Participants shall be permitted to increase or decrease their rates of Contributions effective as of the beginning of each Purchase Period. 

(e)    Notwithstanding the foregoing, to the extent necessary to comply with Section 423(b)(8) of the Code, a
Participant’s Contributions may be decreased to 0% at any time during a Purchase Period. Subject to Section 423(b)(8) of the Code, Contributions will recommence at the rate originally elected by the Participant effective as of the
beginning of the first Purchase Period scheduled to end in the following calendar year, unless terminated by the Participant as provided in Section 10. 

(f)    At the time the option under the Plan is exercised, in whole or in part, or at the time some or all of the Common
Stock issued under the Plan is disposed of (or any other time that a taxable event related to the Plan occurs), the Participant must make adequate provision for the Company’s or Employer’s federal, state, local or any other tax liability
payable to any authority including taxes imposed by jurisdictions outside of the United States, national insurance, social 

  
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security or other tax withholding obligations, if any, which arise upon the exercise of the option or the disposition of the Common Stock (or any other time that a taxable event related to the
Plan occurs). At any time, the Company or the Employer may, but will not be obligated to, withhold from the Participant’s compensation the amount necessary for the Company or the Employer to meet applicable withholding obligations, including
any withholding required to make available to the Company or the Employer any tax deductions or benefits attributable to sale or early disposition of Common Stock by the Eligible Employee. In addition, the Company or the Employer may, but will not
be obligated to, withhold from the proceeds of the sale of Common Stock or any other method of withholding the Company or the Employer deems appropriate to the extent permitted by Treasury Regulation
Section 1.423-2(f). 
  

	7.	 Grant of Option 

On the Enrollment Date of each Offering Period, each Eligible Employee participating in such Offering Period (or any Purchase Period within such Offering
Period) will be granted an option to purchase on each Exercise Date during such Offering Period (at the applicable Purchase Price) up to a number of shares of Common Stock determined by dividing such Eligible Employee’s Contributions
accumulated prior to such Exercise Date and retained in the Eligible Employee’s notional account as of the Exercise Date by the applicable Purchase Price; provided, however, that in no event will an Eligible Employee be permitted to purchase
during each Purchase Period more than 3,000 shares of Common Stock (subject to any adjustment pursuant to Section 18); provided, further, that such purchase will be subject to the limitations set forth in Sections
3(c) and 13. The Eligible Employee may accept the grant of such option by electing to participate in the Plan in accordance with the requirements of Section 5. The Administrator may, for future Offering Periods,
increase or decrease, in its absolute discretion, the maximum number of shares of Common Stock that an Eligible Employee may purchase during each Purchase Period of an Offering Period. Exercise of the option will occur as provided in
Section 8, unless the Participant has withdrawn pursuant to Section 10. The option will expire on the last day of the Offering Period. 

 

	8.	 Exercise of Option 

(a)    Unless a Participant withdraws from the Plan as provided in Section 10, such
Participant’s option for the purchase of shares of Common Stock will be exercised automatically on the Exercise Date, and the maximum number of full shares subject to the option will be purchased for such Participant at the applicable Purchase
Price with the accumulated Contributions from his or her notional account. No fractional shares of Common Stock will be purchased; unless determined by the Administrator, any Contributions accumulated in a Participant’s notional account that
are not sufficient to purchase a full share will be retained in the Participant’s notional account for the subsequent Purchase Period or Offering Period, subject to earlier withdrawal by the Participant as provided in
Section 10. Any other funds left over in a Participant’s notional account after the Exercise Date will be returned to the Participant. During a Participant’s lifetime, a Participant’s option to purchase
shares hereunder is exercisable only by him or her. 
 (b)    If the Administrator determines that, on a given Exercise
Date, the number of shares of Common Stock with respect to which options are to be exercised may exceed (i) the number of shares of Common Stock that were available for sale under the Plan on the Enrollment Date of the applicable Offering
Period, or (ii) the number of shares of Common Stock available for sale under 

  
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the Plan on such Exercise Date, the Administrator may in its sole discretion (x) provide that the Company will make a pro rata allocation of the shares of Common Stock available for purchase
on such Enrollment Date or Exercise Date, as applicable, in as uniform a manner as will be practicable and as it will determine in its sole discretion to be equitable among all Participants exercising options to purchase Common Stock on such
Exercise Date, and continue all Offering Periods then in effect, or (y) provide that the Company will make a pro rata allocation of the shares available for purchase on such Enrollment Date or Exercise Date, as applicable, in as uniform a
manner as will be practicable and as it will determine in its sole discretion to be equitable among all Participants exercising options to purchase Common Stock on such Exercise Date, and terminate any or all Offering Periods then in effect pursuant
to Section 19. The Company may make a pro rata allocation of the shares available on the Enrollment Date of any applicable Offering Period pursuant to the preceding sentence, notwithstanding any authorization of additional
shares for issuance under the Plan by the Company’s stockholders subsequent to such Enrollment Date. 
  

	9.	 Delivery 

As soon as reasonably practicable after each Exercise Date on which a purchase of shares of Common Stock occurs, the Company will arrange the delivery to each
Participant of the shares purchased upon exercise of his or her option in a form determined by the Administrator (in its sole discretion) and pursuant to rules established by the Administrator. The Company may permit or require that shares be
deposited directly with a broker designated by the Company or to a designated agent of the Company, and the Company may utilize electronic or automated methods of share transfer. The Company may require that shares be retained with such broker or
agent for a designated period of time and/or may establish other procedures to permit tracking of disqualifying dispositions of such shares. No Participant will have any voting, dividend, or other stockholder rights with respect to shares of Common
Stock subject to any option granted under the Plan until such shares have been purchased and delivered to the Participant as provided in this Section 9. 

 

	10.	 Withdrawal 

A Participant may withdraw all, but not less than all, the Contributions credited to his or her notional account and not yet used to exercise his or her option
under the Plan at any time by (a) submitting to the Company’s human resources department (or its delegate) a written notice of withdrawal in the form determined by the Administrator for such purpose, or (b) following an electronic or
other withdrawal procedure determined by the Administrator. All of the Participant’s Contributions credited to his or her notional account will be paid to such Participant as soon as reasonably practicable after receipt of notice of withdrawal
and such Participant’s option for the Offering Period will be automatically terminated, and no further Contributions for the purchase of shares will be made for such Offering Period. If a Participant withdraws from an Offering Period,
Contributions will not resume at the beginning of the succeeding Offering Period, unless the Participant re-enrolls in the Plan in accordance with the provisions of Section 5. 

 

	11.	 Termination of Employment 

Upon a Participant’s ceasing to be an Eligible Employee, for any reason, he or she will be deemed to have elected to withdraw from the Plan and the
Contributions credited to such Participant’s notional account during the Offering Period but not yet used to purchase shares of Common Stock under the Plan will be returned to such Participant or, in the case of his or her death, to the person
or persons entitled thereto under Section 15, and such Participant’s option will be automatically terminated. 

  
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	12.	 Interest 

No interest will accrue on the Contributions of a Participant in the Plan, except as may be required by Applicable Law, as determined by the Company, and if so
required by the laws of a particular jurisdiction, shall apply to all Participants in the relevant Offering except to the extent otherwise permitted by Treasury Regulation Section 1.423-2(f). 

 

	13.	 Stock 

(a)    Subject to adjustment upon changes in capitalization of the Company as provided in
Section 18 hereof, the maximum number of shares of Common Stock that will be made available for sale under the Plan shall be equal to (i) 259,689 shares of Common Stock, plus (ii) any shares of Common Stock
added as a result of the following sentence (collectively, the “Share Pool”). The Share Pool will automatically increase on January 1 of each year beginning in 2022 and ending with a final increase on January 1,
2031 in an amount equal to 1% of the total number of shares of Common Stock outstanding on such date (determine on an as-converted to Common Stock basis, without regard to any limitations on the conversion of
the Non-Voting Stock to Common Stock); provided, however, that the Committee may provide that there will be no January 1 increase in the Share Pool for any such year or that the increase in the Share Pool
for any such year will be a smaller number of shares of Common Stock than would otherwise occur pursuant to the preceding sentence. 

(b)    Until the shares are issued (as evidenced by the appropriate entry on the books of the Company or of a duly
authorized transfer agent of the Company), a Participant will only have the rights of an unsecured creditor with respect to such shares, and no right to vote or receive dividends or any other rights as a stockholder will exist with respect to such
shares. 
 (c)    Shares of Common Stock to be delivered to a Participant under the Plan will be registered in the name
of the Participant or in the name of the Participant and his or her spouse. 
  

	14.	 Administration 

The Plan shall be administered by the Administrator. The Board shall fill vacancies on, and from time to time may remove or add members to, the Administrator.
Any power of the Administrator may also be exercised by the Board. The Administrator will have full and exclusive discretionary authority to construe, interpret and apply the terms of the Plan, to designate separate Offerings under the Plan, to
determine eligibility, to adjudicate all disputed claims filed under the Plan and to establish such procedures that it deems necessary for the administration of the Plan (including, without limitation, to adopt such procedures and sub-plans as are
necessary or appropriate to permit the participation in the Plan by employees who are foreign nationals or employed outside the United States, the terms of which sub-plans may take precedence over other provisions of this Plan, with the exception of
Section 13(a), but unless otherwise superseded by the terms of such sub-plan, the provisions of this Plan shall govern the operation of such sub-plan). Unless otherwise 

  
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determined by the Administrator, the employees eligible to participate in each sub-plan will participate in a separate Offering. Without limiting the generality of the foregoing, the
Administrator is specifically authorized to adopt rules and procedures regarding eligibility to participate, the definition of Compensation, handling of Contributions, making of Contributions to the Plan (including, without limitation, in forms
other than payroll deductions), establishment of bank or trust accounts to hold Contributions, payment of interest, conversion of local currency, obligations to pay payroll tax, determination of beneficiary designation requirements, withholding
procedures and handling of stock certificates that vary with applicable local requirements. The Administrator also is authorized to determine that, to the extent permitted by Treasury Regulation
Section 1.423-2(f), the terms of an option granted under the Plan or an Offering to citizens or residents of a non-U.S. jurisdiction will be less favorable than the
terms of options granted under the Plan or the same Offering to employees resident solely in the United States. The Administrator hereby delegates to and designates the Vice President of Finance of the Company (or such other officer with similar
authority), and to his or her delegates or designates, the authority to assist the Administrator in the day-to-day administration of the Plan. The Administrator may also
delegate some or all of its responsibilities to one or more other persons (which may include Company personnel) and, to the extent there has been any such delegation, any reference in the Plan to the Administrator shall include the delegate of the
Administrator. Every finding, decision and determination made by the Administrator will, to the full extent permitted by Applicable Laws, be final and binding upon all parties. 

 

	15.	 Designation of Beneficiary 

(a)    If permitted by the Administrator, a Participant may file a designation of a beneficiary who is to receive any
shares of Common Stock and cash, if any, from the Participant’s notional account under the Plan in the event of such Participant’s death subsequent to an Exercise Date on which the option is exercised but prior to delivery to such
Participant of such shares and cash. In addition, if permitted by the Administrator, a Participant may file a designation of a beneficiary who is to receive any cash from the Participant’s notional account under the Plan in the event of such
Participant’s death prior to exercise of the option. If a Participant is married and the designated beneficiary is not the spouse, spousal consent will be required for such designation to be effective. 

(b)    Such designation of beneficiary may be changed by the Participant at any time by notice in a form determined by the
Administrator. In the event of the death of a Participant and in the absence of a beneficiary validly designated under the Plan who is living at the time of such Participant’s death, the Company will deliver such shares and/or cash to the
executor or administrator of the estate of the Participant, or if no such executor or administrator has been appointed (to the knowledge of the Company), the Company, in its discretion, may deliver such shares and/or cash to the spouse or to any one
or more dependents or relatives of the Participant, or if no spouse, dependent or relative is known to the Company, then to such other person as the Company may designate. 

(c)    All beneficiary designations will be in such form and manner as the Administrator may designate from time to time.
Notwithstanding Sections 15(a) and 15(b), the Company and/or the Administrator may decide not to permit such designations by Participants in non-U.S. jurisdictions to the extent permitted by
Treasury Regulation Section 1.423-2(f). 

  
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	16.	 Transferability 

Neither Contributions credited to a Participant’s notional account nor any rights with regard to the exercise of an option or to receive shares of Common
Stock under the Plan may be assigned, transferred, pledged or otherwise disposed of in any way (other than by will, the laws of descent and distribution or as provided in Section 15) by the Participant. Any such attempt at
assignment, transfer, pledge or other disposition will be without effect, except that the Company may treat such act as an election to withdraw funds from an Offering Period in accordance with Section 10 hereof. 

 

	17.	 Use of Funds 

The Company may use all Contributions received or held by it under the Plan for any corporate purpose, and the Company will not be obligated to segregate such
Contributions except under Offerings in which applicable local law requires that Contributions to the Plan by Participants be segregated from the Company’s general corporate funds and/or deposited with an independent third party for
Participants in non-U.S. jurisdictions. Until shares of Common Stock are issued, Participants will only have the rights of an unsecured creditor with respect to such shares. 

 

	18.	 Adjustments, Dissolution, Liquidation, Merger or Other Corporate Transaction 

(a)    Adjustments. In the event that any dividend or other distribution (whether in the form of cash, Common Stock,
other securities, or other property), recapitalization, stock split, reverse stock split, reorganization, merger, consolidation, split-up, spin-off, combination,
repurchase, or exchange of Common Stock or other securities of the Company, or other change in the corporate structure of the Company affecting the Common Stock occurs, the Administrator, in order to prevent dilution or enlargement of the benefits
or potential benefits intended to be made available under the Plan, will, in such manner as it may deem equitable, adjust the number and class of Common Stock that may be delivered under the Plan, the Purchase Price per share and the number of
shares of Common Stock covered by each option under the Plan that has not yet been exercised, and the numerical limits of Sections 7 and 13. 

(b)    Dissolution or Liquidation. In the event of the proposed dissolution or liquidation of the Company, any
Offering Period then in progress will be shortened by setting a New Exercise Date, and will terminate immediately prior to the consummation of such proposed dissolution or liquidation, unless provided otherwise by the Administrator. The New Exercise
Date will be before the date of the Company’s proposed dissolution or liquidation. The Administrator will notify each Participant in writing or electronically, prior to the New Exercise Date, that the Exercise Date for the Participant’s
option has been changed to the New Exercise Date and that the Participant’s option will be exercised automatically on the New Exercise Date, unless prior to such date the Participant has withdrawn from the Offering Period as provided in
Section 10. 
 (c)    Merger or Other Corporate Transaction. In the event of a merger,
sale or other similar corporate transaction involving the Company, each outstanding option will be assumed or an equivalent option substituted by the successor corporation or a Parent or Subsidiary of the successor corporation. In the event that the
successor corporation refuses to assume or substitute for the option, the Offering Period with respect to which such option relates will be shortened by setting a New Exercise Date on which such Offering Period shall end. The New Exercise Date will

  
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occur before the date of the Company’s proposed merger, sale or other similar corporate transaction. The Administrator will notify each Participant in writing or electronically prior to the
New Exercise Date, that the Exercise Date for the Participant’s option has been changed to the New Exercise Date and that the Participant’s option will be exercised automatically on the New Exercise Date, unless prior to such date the
Participant has withdrawn from the Offering Period as provided in Section 10. 
  

	19.	 Amendment or Termination 

(a)    The Administrator, in its sole discretion, may amend, suspend, or terminate the Plan, or any part thereof, at any
time and for any reason. If the Plan is terminated, the Administrator, in its discretion, may elect to terminate all outstanding Offering Periods either immediately or upon completion of the purchase of shares of Common Stock on the next Exercise
Date (which may be sooner than originally scheduled, if determined by the Administrator in its discretion), or may elect to permit Offering Periods to expire in accordance with their terms (and subject to any adjustment pursuant to
Section 18). If the Offering Periods are terminated prior to expiration, all amounts then credited to Participants’ notional accounts that have not been used to purchase shares of Common Stock will be returned to the
Participants (without interest thereon, except as otherwise required under local laws, as further set forth in Section 12) as soon as administratively practicable. 

(b)    Without stockholder consent and without limiting Section 19(a), the Administrator will be
entitled to change the Offering Periods or Purchase Periods, designate separate Offerings, limit the frequency and/or number of changes in the amount withheld during an Offering Period, establish the exchange ratio applicable to amounts withheld in
a currency other than U.S. dollars, permit payroll withholding in excess of the amount designated by a Participant in order to adjust for delays or mistakes in the Company’s processing of properly completed withholding elections, establish
reasonable waiting and adjustment periods and/or accounting and crediting procedures to ensure that amounts applied toward the purchase of Common Stock for each Participant properly correspond with Contribution amounts, and establish such other
limitations or procedures as the Administrator determines in its sole discretion advisable that are consistent with the Plan. 

(c)    In the event the Administrator determines that the ongoing operation of the Plan may result in unfavorable
financial accounting consequences, the Administrator may, in its discretion and, to the extent necessary or desirable, modify, amend or terminate the Plan to reduce or eliminate such accounting consequence including, but not limited to: 

(i)    amending the Plan to conform with the safe harbor definition under the Financial Accounting
Standards Board Accounting Standards Codification Topic 718 (or any successor thereto), including with respect to an Offering Period underway at the time; 

(ii)    altering the Purchase Price for any Offering Period or Purchase Period including an Offering Period
or Purchase Period underway at the time of the change in Purchase Price; 

  
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 (iii)    shortening any Offering Period or Purchase
Period by setting a New Exercise Date, including an Offering Period or Purchase Period underway at the time of the Administrator action; 

(iv)    reducing the maximum percentage of Compensation a Participant may elect to set aside as
Contributions; and 
 (v)    reducing the maximum number of shares of Common Stock a Participant may
purchase during any Offering Period or Purchase Period. 
 Such modifications or amendments will not require stockholder approval or the consent of any
Participants. 
  

	20.	 Notices 

All notices or other communications by a Participant to the Company under or in connection with the Plan will be deemed to have been duly given when received
in the form and manner specified by the Company at the location, or by the person, designated by the Company for the receipt thereof. 
  

	21.	 Conditions Upon Issuance of Shares 

(a)    Shares of Common Stock will not be issued with respect to an option unless the exercise of such option and the
issuance and delivery of such shares pursuant thereto will comply with all applicable provisions of law, domestic or foreign, including the Securities Act of 1933, as amended, the Exchange Act, the rules and regulations promulgated thereunder, and
the requirements of any stock exchange upon which the shares may then be listed, and will be further subject to the approval of counsel for the Company with respect to such compliance. 

(b)    As a condition to the exercise of an option, the Company may require the person exercising such option to represent
and warrant at the time of any such exercise that the shares are being purchased only for investment and without any present intention to sell or distribute such shares if, in the opinion of counsel for the Company, such a representation is required
by any of the aforementioned applicable provisions of Applicable Law. 
  

	22.	 Term of Plan 

The Plan will become effective upon the earlier to occur of its adoption by the Board or its approval by the stockholders of the Company. It will continue in
effect until terminated pursuant to Section 19. 
  

	23.	 Stockholder Approval 

The Plan will be subject to approval by the stockholders of the Company within 12 months after the date the Plan is adopted by the Board. Such stockholder
approval will be obtained in the manner and to the degree required under Applicable Laws. 

  
 12 

	24.	 Governing Law 

This Plan and any agreements or other documents hereunder shall be interpreted and construed in accordance with the laws of the State of Delaware and
applicable federal law. Any reference in this Plan or in any agreements or other documents hereunder to a provision of law or to a rule or regulation shall be deemed to include any successor law, rule or regulation of similar effect or
applicability. 
  

	25.	 Severability 

If any provision of the Plan is or becomes or is deemed to be invalid, illegal, or unenforceable for any reason in any jurisdiction or as to any Participant,
such invalidity, illegality or unenforceability shall not affect the remaining parts of the Plan, and the Plan shall be construed and enforced as to such jurisdiction or Participant as if the invalid, illegal or unenforceable provision had not been
included. 
  

	26.	 Interpretation 

Headings are given to the Sections and subsections of the Plan solely as a convenience to facilitate reference and shall not be deemed in any way material or
relevant to the construction or interpretation of the Plan or any provision thereof. Words in the masculine gender shall include the feminine gender, and where appropriate, the plural shall include the singular and the singular shall include the
plural. The use herein of the word “including” following any general statement, term or matter shall not be construed to limit such statement, term or matter to the specific items or matters set forth immediately following such word or to
similar items or matters, whether or not non-limiting language (such as “without limitation”, “but not limited to”, or words of similar import) is used with reference thereto, but rather
shall be deemed to refer to all other items or matters that could reasonably fall within the broadest possible scope of such general statement, term or matter. References herein to any agreement, instrument or other document means such agreement,
instrument or other document as amended, supplemented and modified from time to time to the extent permitted by the provisions thereof and not prohibited by the Plan. 

  
 13 

 EXHIBIT A 

RAIN THERAPEUTICS INC. 

2021 EMPLOYEE STOCK PURCHASE PLAN 

SUBSCRIPTION AGREEMENT 
  

			
	             Original Application	  	Offering Date:
                                    
		
	             Change in Payroll Deduction Rate	  	

1.                       
                  hereby elects to participate in the Rain Therapeutics Inc. 2021 Employee Stock Purchase Plan (the “Plan”) and
subscribes to purchase shares of the Company’s Common Stock in accordance with this Subscription Agreement and the Plan. Capitalized terms used but not defined in this Subscription Agreement have the meanings provided under the Plan. 

2.    I hereby authorize payroll deductions from each paycheck in the amount of
            % of my Compensation on each payday (from 1% to 15%) during the Offering Period in accordance with the Plan, commencing with the next Offering Period; provided that, in
no event may more than $25,000 of Common Stock be purchased under the Plan in any calendar year. The minimum permissible projected Contribution for the Offering Period is $500. (Please note that no fractional percentages are permitted.) 

3.    I understand that said payroll deductions will be accumulated for the purchase of shares of Common Stock at the
applicable Purchase Price determined in accordance with the Plan. I understand that if I do not withdraw from an Offering Period, any accumulated payroll deductions will be used to automatically exercise my option and purchase Common Stock under the
Plan. 
 4.    I have received a copy of the complete Plan and its accompanying prospectus. I understand that my
participation in the Plan is in all respects subject to the terms of the Plan. 
 5.    Shares of Common Stock purchased
for me under the Plan should be issued in the name(s) of
                                     (Eligible Employee or
Eligible Employee and Spouse only). 
 6.    I understand that if I dispose of any shares received by me pursuant to the
Plan within two years after the Offering Date (the first day of the Offering Period during which I purchased such shares), I will be treated for federal income tax purposes as having received ordinary income at the time of such disposition in an
amount equal to the excess of the fair market value of the shares at the time such shares were purchased by me over the price that I paid for the shares. I acknowledge and agree that the shares must remain in a brokerage account specified by the
Company until at least 12 months following the Exercise Date and may not be sold by me until at least 12 months after the applicable Exercise Date. The Company may, but will not be obligated to, withhold from my compensation the amount necessary to
meet any applicable withholding 

 
obligation including any withholding necessary to make available to the Company any tax deductions or benefits attributable to sale or early disposition of Common Stock by me. If I dispose of
such shares at any time after the expiration of the two-year holding period, I understand that I will be treated for federal income tax purposes as having received income only at the time of such disposition,
and that such income will be taxed as ordinary income only to the extent of an amount equal to the lesser of (a) the excess of the fair market value of the shares at the time of such disposition over the Purchase Price which I paid for the
shares, or (b) 15% of the fair market value of the shares on the first day of the Offering Period. The remainder of the gain, if any, recognized on such disposition will be taxed as capital gain. 

7.    I hereby agree to be bound by the terms of the Plan. The effectiveness of this Subscription Agreement is dependent
upon my eligibility to participate in the Plan. 
  

			
	 Employee’s Social Security #:
	 	 
		
	 Employee’s Address:
	 	 
		
		 	 

 I UNDERSTAND THAT THIS SUBSCRIPTION AGREEMENT WILL REMAIN IN EFFECT THROUGHOUT SUCCESSIVE OFFERING PERIODS
UNLESS TERMINATED BY ME. 
  

							
	 	 		 	Date:	 	 
	Signature	 		 		 	

  
 A-2 

 EXHIBIT B 

RAIN THERAPEUTICS INC. 

2021 EMPLOYEE STOCK PURCHASE PLAN 

NOTICE OF WITHDRAWAL 
 The
undersigned Participant in the Offering Period of the Rain Therapeutics Inc. 2021 Employee Stock Purchase Plan that began on
                                ,
                 (the “Offering Date”) hereby notifies the Company that he or she hereby withdraws from the Offering Period. He or she
hereby directs the Company to pay to the undersigned as soon as reasonably practicable all the payroll deductions credited to his or her notional account with respect to such Offering Period. The undersigned understands and agrees that his or her
option for such Offering Period will be automatically terminated. The undersigned understands further that no further payroll deductions will be made for the purchase of shares in the current Offering Period and the undersigned will be eligible to
participate in succeeding Offering Periods only by delivering to the Company a new Subscription Agreement. 
  

			
	 Participant’s Name:
	 	 
		
	 Participant’s Address:
	 	 
		
		 	 

  

							
	 	 		 	Date:	 	 
	SignatureEX-10.13

 Exhibit 10.13 

EXCHANGE AGREEMENT 

THIS EXCHANGE AGREEMENT (this “Agreement”) is made as of April 17,
2021, by and among the investors listed on Exhibit A attached hereto (each an “Investor” and together, the “Investors”) and Rain Therapeutics Inc., a Delaware corporation (the
“Company”). 
 RECITALS 

A. Each Investor holds that number of shares of the Company’s Series A Preferred Stock, par value $0.001 per share
(“Series A Preferred”) and the Company’s Series B Preferred Stock, par value $0.001 per share (“Series B Preferred”), set forth opposite such Investor’s name on Exhibit
A attached hereto (the “Preferred Exchange Stock”). 
 B. Subject to the terms and
conditions and limitations set forth herein, each Investor desires to exchange up to the number of shares of Preferred Exchange Stock set forth opposite such Investor’s name on Exhibit A attached hereto for shares of a
newly designated Non-Voting Common Stock of the Company, par value $0.001 per share (the
“Non-Voting Common”). 
 NOW
THEREFORE, in consideration of the foregoing premises and the respective representations and warranties, covenants and agreements contained herein, the receipt and sufficiency of which is hereby acknowledged, the Company and each of the
Investors agree as follows: 
 Article I: Exchange 

1.1 Upon the terms and subject to the conditions herein contained, at the Closing (as defined below), the Applicable Number of Shares (defined
below) of Preferred Exchange Stock held by each investor shall, automatically, and without any further action on the part of the Investors or the Company, be exchanged for shares of Non-Voting Common
at a ratio of 1.0799 shares of Non-Voting Common for every single share of Preferred Exchange Stock (rounded down to the nearest whole share). Each Investor shall assign and deliver to the Company
Preferred Exchange Stock (including any stock certificates representing the Applicable Number of Shares) for cancellation by the Company, free and clear of any mortgage, lien, pledge, charge, security interest, encumbrance, title retention
agreement, option, equity or other adverse claim thereto (collectively, “Liens”), other than restrictions on transfer under applicable securities laws, together with any documents of conveyance or transfer that the Company
may deem reasonably necessary or desirable, and in exchange therefor the Company shall issue to each Investor 1.0799 shares of Non-Voting Common (rounded down to the nearest whole share) for each
single share of Preferred Exchange Stock exchanged hereunder. The “Applicable Number of Shares” shall mean, for each Investor, such number of shares of Preferred Exchange Stock (which may be zero) as would be necessary to
cause such Investor, immediately following the closing of the IPO, to beneficially own (for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended and the rules and regulations promulgated thereunder (collectively, the
“Exchange Act”)), when aggregated with such Investor’s affiliates who are also party hereto, not more than 9.99% (or such other amount as may be agreed to by the Company and the applicable Investor) of the Company’s
Voting Common Stock. The exchange of the Preferred Exchange Stock for the Non-Voting Common pursuant to this Agreement is referred to herein as the “Exchange.” 

1.2 Each Investor severally, and not jointly, shall be liable for only the Exchange that relates to such Investor. The Company’s agreement
with each of the Investors is a separate agreement, and the Exchange with respect to each Investor is a separate exchange. The obligations of each Investor hereunder are expressly not conditioned on the exchange of
the Non-Voting Stock by any or all of the other Investors. 
 1.3 Subject to the
satisfaction of each of the conditions set forth in Article IV and Article V hereof (to the extent not waived in accordance therewith), the closing of the Exchange (the “Closing”) shall take place remotely immediately
prior to the closing of a firm-commitment underwritten public offering of the Company’s Voting Common Stock pursuant to the Company’s Registration Statement on Form S-1 (file number 333-254998) (the “IPO”) (the date on which such Closing occurs is hereinafter referred to as the “Closing Date”). 

 Article II: Covenants, Representations and Warranties of Each Investor 

Each Investor, severally and not jointly, hereby covenants as follows, and makes the following representations and warranties, each of which
is and shall be true and correct on the date hereof and at the Closing, to the Company and all such covenants, representations and warranties shall survive the Closing. 

2.1. Power and Authorization. The Investor is duly organized, validly existing and in good standing, and has the power,
authority and capacity to execute and deliver this Agreement, to perform its obligations hereunder, and to consummate the Exchange contemplated hereby. 

2.2. Valid and Enforceable Agreement; No Violations. This Agreement has been duly executed and delivered by the Investor and
constitutes a legal, valid and binding obligation of the Investor, enforceable against the Investor in accordance with its terms, except that such enforcement may be subject to (a) bankruptcy, insolvency, fraudulent transfer, reorganization,
moratorium or other similar laws affecting or relating to enforcement of creditors’ rights generally, and (b) general principles of equity, whether such enforceability is considered in a proceeding at law or in equity (the
“Enforceability Exceptions”). This Agreement and the consummation of the Exchange will not materially violate, conflict with or result in a breach of or default under (i) the Investor’s organizational documents,
(ii) any agreement or instrument to which the Investor is a party or by which the Investor or any of its assets are bound, or (iii) any laws, regulations or governmental or judicial decrees, injunctions or orders applicable to the
Investor. 
 2.3. Title to Preferred Exchange Stock. The Investor is the sole legal and beneficial owner of the
Preferred Exchange Stock set forth opposite such Investor’s name on Exhibit A hereto. The Investor has good and valid title to its Preferred Exchange Stock, free and clear of any Liens, other than restrictions on
transfer under applicable securities. The Investor has not, in whole or in part, except as described in the preceding sentence, (a) assigned, transferred, hypothecated, pledged, exchanged, syndicated, endorsed or otherwise disposed of any of
its Preferred Exchange Stock or any of its rights in any of its Preferred Exchange Stock, or (b) given any person or entity any transfer order, power of attorney, endorsement or other authority of any nature whatsoever with respect to its
Preferred Exchange Stock. Upon the Investor’s delivery of its Preferred Exchange Stock to the Company pursuant to the Exchange, the Preferred Exchange Stock shall be free and clear of all Liens created by the Investor, other than restrictions
on transfer under applicable securities laws. 
 2.4. No Reliance. The Investor is not relying, and has not relied,
upon any statement, advice (whether accounting, tax, financial, legal or other), representation or warranty made by the Company or any of its affiliates or representatives, except for the representations and warranties made by the Company in
this Agreement. 
 2.5. Tax Consequences of the Exchange. The Investor understands that the tax consequences of the
Exchange will depend in part on its own tax circumstances. The Investor acknowledges that it must consult its own tax adviser about the federal, foreign, state and local tax consequences peculiar to its circumstances. 

2.6. No Public Market. The Investor acknowledges and agrees that no public market exists for the Non-Voting Common and no public market is expected to develop for the Non-Voting Common. 

2.7. Transfer Restrictions. Each Investor acknowledges and agrees as follows: 

(a) The Non-Voting Common and the Conversion Shares have not been registered for sale under
the Securities Act of 1933, as amended (the “Securities Act”) in reliance on Section 3(a)(9) of the Securities Act; the Company does not currently intend to register
the Non-Voting Common or the Conversion Shares under the Securities Act at any time in the future. The Investor understands that
the Non-Voting Common are “restricted securities” under applicable U.S. federal and state securities laws and that, pursuant to these laws, the Investor must hold the Non-Voting Common indefinitely unless they are registered with the Securities and Exchange Commission (the “SEC”) and qualified by state authorities, or an exemption from such
registration and qualification requirements is available. The Investor acknowledges that the Company has no obligation to register or qualify the Non-Voting Common, or the Conversion Shares, except
as set forth in that certain Amended and Restated Investors’ Rights Agreement, dated September 2, 2020, by and among the Company and the investors listed on Schedule A attached thereto. The

  
 2 

 
Investor further acknowledges that if an exemption from registration or qualification is available, it may be conditioned on various requirements including, but not limited to, the time and
manner of sale, the holding period for the Non-Voting Common, and on requirements relating to the Company which are outside of the Investor’s control, and which the Company is under no
obligation and may not be able to satisfy. 
 (b) The Investor understands that
the Non-Voting Common and the Conversion Shares may be notated with one or all of the following legends: 

(i) “THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, AND HAVE BEEN ACQUIRED FOR
INVESTMENT AND NOT WITH A VIEW TO, OR IN CONNECTION WITH, THE SALE OR DISTRIBUTION THEREOF. NO SUCH TRANSFER MAY BE EFFECTED WITHOUT AN EFFECTIVE REGISTRATION STATEMENT RELATED THERETO OR AN OPINION OF COUNSEL IN A FORM SATISFACTORY TO THE COMPANY
THAT SUCH REGISTRATION IS NOT REQUIRED UNDER THE SECURITIES ACT OF 1933, AS AMENDED.” 
 (ii) Any legend or legends currently set forth
on the certificates of the Preferred Exchange Stock held by the Investor immediately prior to the Exchange. 
 2.8. No
Remuneration. Neither the Investor nor any of its affiliates, nor any person acting on behalf of or for the benefit of any of the forgoing, has paid or given, or agreed to pay or give, directly or indirectly, any commission or other remuneration
(within the meaning of Section 3(a)(9) of the Securities Act and the rules and regulations of the SEC promulgated thereunder) for soliciting the Exchange, and the Investor has received no additional consideration for the Preferred Exchange
Stock other than the Non-Voting Common. 
 Article III: Covenants, Representations and
Warranties of the Company 
 The Company hereby covenants as follows, and makes the following representations and warranties, each of
which is and shall be true and correct on the date hereof and at the Closing, to each Investor, and all such covenants, representations and warranties shall survive the Closing. 

3.1. Power and Authorization. The Company is duly incorporated, validly existing and in good standing under the laws of its
state of incorporation, and has the power, authority and capacity to execute and deliver this Agreement, to perform its obligations hereunder, and to consummate the Exchange contemplated hereby. 

3.2. Valid and Enforceable Agreement; No Violations. This Agreement has been duly executed and delivered by the Company and
constitutes a legal, valid and binding obligation of the Company, enforceable against it in accordance with its terms, except that such enforcement may be subject to the Enforceability Exceptions. The issuance of
the Non-Voting Common and the Conversion Shares have been duly authorized by the Company. This Agreement, the issuance of the Non-Voting Common and
consummation of the Exchange will not violate, conflict with or result in a breach of or default under (a) the charter, bylaws or other organizational documents of the Company, (b) any agreement or instrument to which the Company is a
party or by which the Company or any of its assets are bound, or (c) any laws, regulations or governmental or judicial decrees, injunctions or orders applicable to the Company. 

3.3. Validity of Underlying Common Stock. The Non-Voting Common will, at the
Closing, be convertible into shares of the Company’s Voting Common Stock, par value $0.001 (the “Conversion Shares”), in accordance with the Company’s Amended and Restated Certificate of Incorporation then in effect
(as it may be amended, and/or amended and restated or otherwise modified from time to time, the “Charter”). The Conversion Shares have been duly authorized and reserved by the Company for issuance upon conversion of the Non-Voting Common, and, when issued upon conversion of the Non-Voting Common in accordance with the Charter, will be validly issued, fully paid and non-assessable, and the issuance of the Conversion Shares will not be subject to any preemptive, participation, rights of first refusal or other similar rights. 

3.4. Validity of the Non-Voting Common. The Non-Voting Common to be issued pursuant to this Agreement at the Closing (a) have been duly authorized by the Company and, upon their issuance pursuant to the Exchange in accordance with the
terms of this Agreement, the Non-Voting Common will be validly issued, fully- paid and non-assessable and (b) will not, as of the date of
issuance, be subject to any preemptive, participation, rights of first refusal or other similar rights. 

  
 3 

 Article IV: Conditions to Company’s Obligations at Closing 

The Company’s obligation to complete the Exchange and deliver the Non-Voting Common to
each Investor in exchange for the Preferred Exchange Stock shall be subject to the following conditions to the extent not waived by the Company: 

4.1. Representation and Warranties. The representations and warranties made by the Investors in Article II hereof shall be true and
correct in all respects as of, and as if made on, the date of this Agreement and as of the Closing Date, except to the extent any such representation or warranty expressly speaks as of an earlier date, in which case such representation or warranty
shall be true and correct as of such earlier date. 
 4.2. Performance. Each Investor shall have performed in all material
respects all obligations and covenants herein required to be performed by it at or prior to the Closing. 
 Article V: Conditions to
Investors’ Obligations at Closing 
 Each Investor’s obligation to deliver the Preferred Exchange Stock and accept delivery of
the Non-Voting Common and to effect the Exchange shall be subject to the following conditions to the extent not waived by the Investors: 

5.1. Representations and Warranties. The representations and warranties made by the Company in Article III hereof shall be true and
correct in all material respects (except to the extent any such representation and warranty is qualified by materiality, in which case, such representation and warranty shall be true and correct in all respects as so qualified) as of, and as if made
on, the date of this Agreement and as of the Closing Date, except to the extent any such representation or warranty expressly speaks as of an earlier date, in which case such representation or warranty shall be true and correct as of such earlier
date. 
 5.2. Performance. The Company shall have performed in all material respects all obligations and covenants herein
required to be performed by it at or prior to the Closing. 
 5.3. Judgments. No judgment, writ, order, injunction, award or
decree of or by any court, or judge, justice or magistrate, including any bankruptcy court or judge, or any order of or by any governmental authority, shall have been issued, and no action or proceeding shall have been instituted by any governmental
authority, enjoining or preventing the consummation of the transactions contemplated hereby. 
 5.4. Amended and Restated Certificate
of Incorporation. The Company shall have filed the Charter designating the rights of the Non-Voting Common with the Secretary of State of the State of Delaware, and the Charter shall remain in
full force and effect as of the Closing Date. 
 Article VI: Miscellaneous 

6.1. Entire Agreement. This Agreement and any other documents and agreements executed in connection with this Agreement or
the Exchange embody the entire agreement and understanding of the parties hereto with respect to the subject matter hereof and supersede all prior and contemporaneous oral or written agreements, representations, warranties, contracts,
correspondence, conversations, memoranda and understandings between or among the parties or any of their agents, representatives or affiliates relative to such subject matter, including, without limitation, any term sheets, emails or draft
documents. This Agreement shall be binding upon, and shall be enforceable by and inure solely to the benefit of, the Company and the Investors and their respective successors and permitted assigns; provided, however, that neither
this Agreement nor any of the rights hereunder may be assigned without the prior written consent of the other parties to this Agreement, and any attempted assignment of this Agreement or any of such rights without such consent shall be void and of
no effect 

  
 4 

 6.2. Amendment. This Agreement may not be amended except by an
instrument in writing signed on behalf of each of the parties to this Agreement. 
 6.3. Termination. This Agreement shall
automatically terminate and be of no further effect on July 30, 2021, in the event the closing of the IPO shall not have occurred on or before such date. 

6.4. Governing Law. This Agreement shall in all respects be construed in accordance with and governed by the substantive laws of
the State of Delaware, without reference to its choice of law rules. 
 6.5. Severability. Any term or provision of
this Agreement that is invalid or unenforceable in any situation in any jurisdiction shall not affect the validity or enforceability of the remaining terms and provisions of this Agreement or the validity or enforceability of the offending term or
provision in any other situation or in any other jurisdiction. If a final judgment of a court of competent jurisdiction declares that any term or provision of this Agreement is invalid or unenforceable, the parties agree that the court making such
determination shall have the power to limit such term or provision, to delete specific words or phrases or to replace such term or provision with a term or provision that is valid and enforceable and that comes closest to expressing the intention of
the invalid or unenforceable term or provision, and this Agreement shall be valid and enforceable as so modified. In the event such court does not exercise the power granted to it in the prior sentence, the parties agree to replace such invalid or
unenforceable term or provision with a valid and enforceable term or provision that will achieve, to the extent possible, the economic, business and other purposes of such invalid or unenforceable term or provision. 

6.6. Waiver of Conflicts. Each party to this Agreement acknowledges that Gibson, Dunn & Crutcher, LLP
(“Gibson Dunn”), outside general counsel to the Company, has in the past performed and is or may now or in the future represent one or more Investors or their affiliates in matters unrelated to the transactions contemplated
by this Agreement (the “Transactions”), including representation of such Investors or their affiliates in matters of a similar nature to the Transactions. The applicable rules of professional conduct require that Gibson Dunn
inform the parties hereunder of this representation and obtain their consent to Gibson Dunn’s representation of the Company in connection with the negotiation, preparation, execution and performance of this Agreement and the consummation of the
Transactions. Gibson Dunn has served as outside general counsel to the Company and has negotiated the terms of the Transactions solely on behalf of the Company. The Company and each Investor hereby (a) acknowledge that they have had an
opportunity to ask for and have obtained information relevant to such representation, including disclosure of the reasonably foreseeable adverse consequences of such representation; (b) acknowledge that with respect to the negotiation,
preparation, execution and performance of this Agreement and the consummation of the Transactions, Gibson Dunn has represented solely the Company, and not any Investor or any stockholder, member, beneficiary, director or employee of any Investor;
and (c) gives its informed consent to Gibson Dunn’s representation of the Company in connection with the negotiation, preparation, execution and performance of this Agreement and the consummation of the Transactions. 

6.7. Counterparts. This Agreement may be executed in counterparts, each of which shall be deemed an original, but all of which
together shall constitute one and the same instrument. Counterparts may be delivered via electronic mail (including pdf or any electronic signature complying with the U.S. federal ESIGN Act of 2000, e.g., www.docusign.com) or other transmission
method and any counterpart so delivered shall be deemed to have been duly and validly delivered and be valid and effective for all purposes. 

[Signature pages follow.] 

  
 5 

 IN WITNESS WHEREOF, the undersigned has executed, or caused to be executed on its
behalf by an agent there unto duly authorized, this Exchange Agreement as of the date first above written. 
  

			
	Rain Therapeutics Inc.
		
	By:	 	 /s/ Avanish Vellanki

	Name:	 	Avanish Vellanki
	Title:	 	Chief Executive Officer
	Address:	 	8000 Jarvis Avenue, Suite 204
		 	Newark, CA 94560

 [Signature Page to Exchange Agreement] 

 IN WITNESS WHEREOF, the undersigned has executed, or caused to be executed on its
behalf by an agent there unto duly authorized, this Exchange Agreement as of the date first above written. 
  

			
	INVESTORS:
	
	Biotechnology Value Fund, L.P.
		
	By:	 	 /s/ Mark Lampert

		 	NAME: Mark Lampert
		 	TITLE: Chief Executive Officer BVF I GP LLC, itself General Partner of Biotechnology Value Fund, L.P.
	
	Biotechnology Value Fund II, L.P.
		
	By:	 	 /s/ Mark Lampert

		 	NAME: Mark Lampert
		 	TITLE: Chief Executive Officer BVF II GP LLC, itself General Partner of Biotechnology Value Fund II, L.P.
	
	Biotechnology Value Trading Fund OS, L.P.
		
	By:	 	 /s/ Mark Lampert

		 	NAME: Mark Lampert
		 	TITLE: President BVF Inc., General Partner of BVF Partners L.P., itself sole member of BVF Partners OS Ltd., itself GP of Biotechnology Value Trading Fund OS, L.P.

 [Signature Page to Exchange Agreement] 

 
			
	Cormorant Private Healthcare Fund II, LP
	
	By: Cormorant Private Healthcare GP II, LLC
	By:	 	 /s/ Bihua Chen

		 	NAME: Bihua Chen
		 	TITLE: Managing Member
	
	Cormorant Private Healthcare Fund III, LP
	By: Cormorant Private Healthcare Fund III, LP
		
	By:	 	 /s/ Bihua Chen

		 	NAME: Bihua Chen
		 	TITLE: Managing Member
	
	Cormorant Global Healthcare Master Fund LP
	By: Cormorant Global Healthcare GP, LLC
		
	By:	 	 /s/ Bihua Chen

		 	NAME: Bihua Chen
		 	TITLE: Managing Member
	
	Boxer Capital, LLC
		
	By:	 	 /s/ Aaron Davis

		 	NAME: Aaron Davis
		 	TITLE: Chief Executive Officer
	
	MVA Investors, LLC
		
	By:	 	 /s/ Aaron Davis

		 	NAME: Aaron Davis
		 	TITLE: Chief Executive Officer

 [Signature Page to Exchange Agreement]

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