Document:

Exhibit 10.72

Exhibit 10.72

SUPERVISORY AGREEMENT

This Supervisory Agreement (Agreement) is made this 15th day of March, 2010 (Effective
Date), by and through the Board of Directors (Board) of NCB, FSB, Hillsboro, Ohio, OTS Docket No.
08527 (Association) and the Office of Thrift Supervision (OTS), acting by and through its Regional
Director for the Central Region (Regional Director).

WHEREAS, the Association, which is subject to examination, regulation and supervision by the
OTS;

WHEREAS, the OTS has the statutory authority pursuant to 12 U.S.C. § 1818 to enter into and
enforce supervisory agreements to ensure the establishment and maintenance of appropriate
safeguards in the operation of the entities it regulates;

WHEREAS, in furtherance of their common goal to ensure that the Association
continues to address the unsafe or unsound practices or violations of law or regulation identified
by the OTS in the July 6, 2009 Report of Examination (2009 ROE), the Association, without admitting
or denying that such grounds exist, and the OTS have mutually agreed to enter into this Agreement;
and

WHEREAS, the Association’s Board duly adopted a resolution (Board Resolution) that authorizes
the Association to enter into this Agreement and directs compliance by the Association and its
directors, officers, employees, and other institution-affiliated parties with each and every
provision of this Agreement.

NOW THEREFORE, in consideration of the above premises, it is agreed as follows:

Business Plan.

	1.	 	(a) Within forty-five (45) days, the Association shall submit a business
plan for January 1, 2010 through December 31, 2011 (Business Plan) that is

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	 	 	acceptable to the Regional Director. At a minimum, the Business Plan shall
incorporate the recommendations contained in the 2009 ROE and requirements of this
Agreement, and include:

(i) establishment of a minimum Tier 1 (Core) Capital Ratio and Total Risk-Based
Capital Ratio commensurate with the Association’s risk profile;

(ii) detailed capital preservation and enhancement strategies with date specific
narrative goals;

(iii) development of and steps for implementing operating strategies by business
line to achieve increased core deposits, realistic core earnings and net income
levels, with the goal of achieving profitable operation of the Association while
reducing reliance on volatile funding sources;

(iv) maintenance of adequate Allowance for Loan and Lease Losses (ALLL) provisions;

(v) procedures designed to ensure quarterly Board review of the external and
internal risks that may affect the Association’s ability to implement the operations
and lines of business contained in the Business Plan. The Board review shall
include, but not be limited to, adverse scenarios relating to asset or liability
mixes, interest rates, staffing levels and expertise, operating expenses, marketing
costs, and economic conditions in the markets where the Association is operating;

(vi) detailed quarterly financial projections of the Association on a stand-alone
basis for the period beginning with January 1, 2010 through December 31, 2011; and

(vii) detailed assumptions for all financial projections, such as

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the assumed interest rate scenarios; noninterest income and noninterest expense;
disposition of real estate owned (REO); ALLL; cost of funds projections; and loan
origination rates using recent experience and taking into consideration current
national and regional economic conditions.

(b) Within thirty (30) days of receipt of written non-objection from the Regional Director,
the Association shall implement the Business Plan. A copy of the Business Plan shall be
provided to the Regional Director within ten (10) days after Board approval.

(c) The Association must operate within the parameters of its Business Plan. Any proposed
material deviations1 from or changes to the Business Plan shall be submitted for
the prior, written non-objection of the Regional Director. Requests for any material
deviations or changes must be submitted at least sixty (60) days before a proposed change is
implemented.

	2.	 	(a) Within forty-five (45) days of the end of each quarter, beginning with the quarter ending
June 30, 2010, the Association shall provide the Board to review written reports comparing
projected operating results contained within the Business Plan to actual results (Variance
Analysis Reports). The reports shall include a thorough and diligent review and assessment of
the Senior Executive Officers’ 2 implementation of and the Association’s compliance
with the Business Plan. The Board’s review of these reports and compliance with the Business
Plan shall be fully documented in the appropriate Board meeting minutes.

 

	 	 	 
	1	 	A deviation shall be considered material under this
Subparagraph of the Agreement if the Association plans to: (a) engage in any
activity that is inconsistent with the Business Plan; or (b) exceed the level
of any activity contemplated in the Business Plan or fail to meet target
amounts established in the Business Plan by more than ten percent (10%), unless
the activity involves assets risk-weighted fifty percent (50%) or less, in
which case a variance of more than twenty-five percent (25%) shall be deemed to
be a material deviation.
	 
	2	 	The term “Senior Executive Officer” is defined at 12
C.F.R. § 563.555.

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(b) Within sixty (60) days of the end of each quarter beginning with the quarter ending June
30, 2010, the Board shall provide the Regional Director with a copy of the Variance Analysis
Report required by this Paragraph.

Liquidity Risk Management Program.

	3.	 	(a) Within thirty (30) days, the Association
shall submit to the Regional Director an
updated Liquidity Management Policy and
Liquidity Contingency Plan that is
acceptable to the Regional Director to
identify and monitor on an ongoing basis
the Association’s current and projected
funding needs and access to sufficient
funds to meet those needs (Liquidity Risk
Management Program). At a minimum, the
Liquidity Risk Management Program shall
include:

(i) a monthly review by the Board of deposit structure, including volume
and trend to total deposits; maturity distribution of time deposits; rates being
paid on each type of deposit in comparison to competitors in the Association’s trade
area; and limits on large time deposits, public funds and out-of-area deposits;

(ii) limits on concentrations in or excessive reliance upon any single
source or type of funding, such as brokered funds, internet deposits, or similar
rate sensitive or credit sensitive deposits;

(iii) methodologies for computing the cost of funds and analyzing marginal
funding costs, and incorporating those results into the Association’s asset and
liability committee (ALCO) decisions and written profit plan strategies;

(iv) acceptable risk tolerance levels, such as individual and aggregate limits
on borrowed funds by type and source, or a minimum limit on the amount of short-term
investments;

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(v) a minimum liquidity ratio and defining how the ratio is to be
calculated;

(vi) the proper use of borrowings (i.e., seasonal credit needs, match funding
of loans, etc.); the manner in which the borrowing strategy will be approved and
documented; the means by which the Association will avoid concentration of funding
sources; and pricing and collateral requirements with specific allowable funding
channels identified (e.g., internet deposits, Fed funds purchased, and other
correspondent borrowings);

(vii) written monthly reports to the Board detailing the Association’s
liquidity position, including the Association’s net non-core funding ratio;

(viii) a written Liquidity Contingency Plan including identification of possible
sources of funds and priority for their implementation;

(ix) submitting a quarterly cash flow analysis acceptable to the Regional Director
or more frequently as requested by the Regional Director; and

(x) appropriate lines of credit at correspondent banks, including the
Federal Reserve Bank, that would allow the Association to borrow funds to meet
depositor demands if the Association’s other provisions for liquidity prove to be
inadequate;

(xi) the retention of securities and other identified categories of
investments that can be liquidated within one day in amounts sufficient (as a
percentage of the Association’s total assets) to ensure the maintenance of the
Association’s liquidity position at a level consistent with short- and long-term
liquidity objectives;

(xii) monitoring of current market conditions affecting liquidity generally as well
as the specific funding sources relied on by the Association.

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(b) Within thirty (30) days of receipt of written non-objection from the Regional Director,
the Association shall implement the Liquidity Risk Management Program.

Allowance for Loan and Lease Losses.

	4.	 	(a) Within forty-five (45) days, the
Association shall revise its policies,
procedures, and methodology to ensure the
timely establishment and maintenance of an
adequate ALLL in accordance with applicable
laws, regulations and regulatory guidance
(ALLL Policy) that is acceptable to the
Regional Director.

(b) Within thirty (30) days of receipt of written non-objection from the Regional Director,
the Association shall implement the ALLL Policy. A copy of the ALLL Policy shall be
provided to the Regional Director within seven (7) days after Board approval.

(c) Within fifteen (15) days, the Association shall submit the name, experience, and
qualifications of an independent third-party to conduct a review and validation of the
Association’s ALLL methodology used for commercial real estate and commercial loans to the
Regional Director for written non-objection. The Association shall retain the independent
third-party within fifteen (15) days of receipt of written non-objection from the Regional
Director. The engagement letter between the Association and the third party shall require
that within forty-five (45) days after the date of the execution of the engagement letter,
the final written validation report containing the findings and recommendations issued by
the third party shall be sent simultaneously to the Board and to the Regional Director.

Mission-Critical Contingency Plan.

	5.	 	(a) Within forty-five (45) days, the
Association shall submit a written
contingency plan that identifies
alternative sources of or providers for the
data processing,

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administrative, and managerial services currently provided to the Association by the
Association’s affiliates (Mission-Critical Contingency Plan) that is acceptable to the
Regional Director. The Mission-Critical Contingency Plan shall provide guidance to
Association management and employees that can be implemented immediately, if necessary. At
a minimum, the Mission-Critical Contingency Plan shall:

(i) identify alternative suppliers and vendors that the Association may rely upon to
supply the services that may be used in place of, and that are fully compatible
with, the current outsourced services; and

(ii) outline the circumstances under which the Association may enter into a binding
agreement with a non-affiliate servicer provider.

(b) Within thirty (30) days of receipt of written non-objection from the Regional Director,
the Board shall adopt the Mission-Critical Contingency Plan. A copy of the Mission-Critical
Contingency Plan shall be provided to the Regional Director within ten (10) days after Board
approval.

Growth.

6. Effective immediately, the Association shall not increase its total assets during any quarter in
excess of an amount equal to net interest credited on deposit liabilities during the quarter
without the prior written approval of the Regional Director. The growth restrictions imposed by
this Paragraph shall remain in effect until the Association receives the Regional Director’s
written non-objection of its Business Plan pursuant to Paragraph 1 of this Agreement.

Dividends.

7. Effective immediately, the Association shall not declare or pay dividends or make any other
capital distribution, as that term is defined in 12 C.F.R. § 563.141, without receiving the

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prior written approval of the Regional Director. The Association’s written request for approval
shall be submitted to the Regional Director at least sixty (60) days prior to the anticipated date
of the proposed declaration, dividend, or distribution of capital.

Severance and Indemnification Payments.

8. Effective immediately, the Association shall not make any golden parachute payment3
or any prohibited indemnification payment4 unless, with respect to each such payment,
the Association has complied with the requirements of 12 C.F.R. Part 359 and, as to indemnification
payments, 12 C.F.R. § 545.121.

Directorate and Management Changes.

9. Effective immediately, the Association shall comply with the prior notification requirements for
changes in directors and Senior Executive Officers set forth in 12 C.F.R. Part 563, Subpart H.

Employment Contracts and Compensation Arrangements.

	10.	 	(a) Effective immediately, the
Association shall not enter into
any new contractual arrangement
or renew, extend, or revise any
existing contractual arrangement
relating to compensation or
benefits for any Senior Executive
Officer or director of the
Association, unless it first
provides the Regional Director
with not less than thirty (30)
days prior written notice of the
proposed transaction. The notice
to the Regional Director shall
include a copy of the proposed
employment contract or
compensation arrangement or a
detailed, written description of
the compensation arrangement to
be offered to such Senior
Executive Officer or director,
including all benefits and
perquisites. The Board shall
ensure that any contract,
agreement, or arrangement
submitted to the Regional

 

	 	 	 
	3	 	The term “golden parachute payment” is defined at 12
C.F.R. § 359.1(f).
	 
	4	 	The term “prohibited indemnification payment” is
defined at 12 C.F.R. § 359.1(l).

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Director fully complies with the requirements of 12 C.F.R. Part 359, 12 C.F.R. §§ 563.39 and
563.161(b), and 12 C.F.R. Part 570 — Appendix A.

(b) Effective immediately, the Association shall not increase any salaries, bonuses, or
director’s fees or make any other similar payments, directly or indirectly, to the
Association’s directors or Senior Executive Officers without prior written non-objection
from the Regional Director.

Third Party Contracts. 

11. Effective immediately, the Association shall not enter into any new arrangement or contract or
renew, extend or revise any existing arrangement or contract with a third party service provider
that is significant to the overall operation or financial condition of the Association5
or outside the Association’s normal course of business unless, with respect to each such contract,
the Association has: (a) provided the Regional Director with a minimum of thirty (30) days prior
written notice of such arrangement or contract; (b) determined that the arrangement or contract
complies with the standards and guidelines set forth in OTS Thrift Bulletin 82a; and (c) received
written notice of non-objection from the Regional Director.

Effective
Date.

12. This Agreement is effective on the Effective Date as shown on the first page.

Duration.

13. This Agreement shall remain in effect until terminated, modified or suspended, by written
notice of such action by the OTS, acting by and through its authorized representatives.

 

	 	 	 
	5	 	A contract will be considered significant to the
overall operation or financial condition of the Association where the annual
contract amount equals or exceeds two percent (2%) of the Association’s total
capital.

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Time Calculations.

14. Calculation of time limitations for compliance with the terms of this Agreement run from the
Effective Date and shall be based on calendar days, unless otherwise noted.

Submissions and Notices.

15. All submissions, including progress reports, to the OTS that are required by or contemplated by
the Agreement shall be submitted within the specified timeframes.

16. Except as otherwise provided herein, all submissions, requests, communications, consents or
other documents relating to this Agreement shall be in writing and sent by first class U.S. mail
(or by reputable overnight carrier, electronic facsimile transmission or hand delivery by
messenger) addressed as follows:

	 	(a)	 	To the OTS:
	 
	 	 	 	Regional Director

Office of Thrift Supervision

One South Wacker Drive, Suite 2000

Chicago, Illinois 60606

Facsimile: (312) 917-5001
	 
	 	(b)	 	To the Association:
	 
	 	 	 	Chairman of the Board

NCB, FSB

2011 Crystal Drive, Suite 800

Arlington, Virginia 22202-3709

Facsimile: (703) 647-4203

No Violations Authorized.

17. Nothing in this Agreement shall be construed as allowing the Association, its Board, officers
or employees to violate any law, rule, or regulation.

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OTS Authority Not Affected.

18. Nothing in this Agreement shall inhibit, estop, bar or otherwise prevent the OTS from taking
any other action affecting the Association if at any time the OTS deems it appropriate to do so to
fulfill the responsibilities placed upon the OTS by law.

Other Governmental Actions Not Affected.

19. The Association acknowledges and agrees that its execution of the Agreement is solely for the
purpose of resolving the matters addressed herein, consistent with Paragraph 19 above, and does not
otherwise release, discharge, compromise, settle, dismiss, resolve, or in any way affect any
actions, charges against, or liability of the Association that arise pursuant to this action or
otherwise, and that may be or have been brought by any governmental entity other than the OTS.

Miscellaneous.

20. The laws of the United States of America shall govern the construction and validity of this
Agreement.

21. If any provision of this Agreement is ruled to be invalid, illegal, or unenforceable by the
decision of any Court of competent jurisdiction, the validity, legality, and enforceability of the
remaining provisions hereof shall not in any way be affected or impaired thereby, unless the
Regional Director in his or her sole discretion determines otherwise.

22. All references to the OTS in this Agreement shall also mean any of the OTS’s predecessors,
successors, and assigns.

23. The section and paragraph headings in this Agreement are for convenience only and shall not
affect the interpretation of this Agreement.

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24. The terms of this Agreement represent the final agreement of the parties with respect to the
subject matters thereof, and constitute the sole agreement of the parties with respect to such
subject matters.

Enforceability of Agreement.

25. This Agreement is a “written agreement” entered into with an agency within the meaning and for
the purposes of 12 U.S.C. § 1818.

Signature of Directors/Board Resolution.

26. Each Director signing this Agreement attests that he or she voted in favor of a Board
Resolution authorizing the consent of the Association to the issuance and execution of the
Agreement. This Agreement may be executed in counterparts by the directors after approval of
execution of the Agreement.

WHEREFORE, the OTS, acting by and through its Regional Director, and the Board of the
Association, hereby execute this Agreement.

	 	 	 	 	 	 	 	 	 
	NCB, FSB 

Hillsboro, Ohio	 	 	 	OFFICE OF THRIFT SUPERVISION	 	 
	 
	 	 	 	 	 	 	 	 
	/s/

	 	 	 	By:
	 	/s/	 	 
	 

	 	 	 	 	 	 	 	 
	Charles E. Snyder, Chairman

	 	 	 	 	 	Daniel T. McKee	 	 
	 
	 	 	 	 	 	Regional Director, Central Region	 	 
	 
	 	 	 	 	 	 	 	 
	/s/
 

Steven A. Brookner, Director

	 	 	 	 	 	Date: See Effective Date on page 1 	 	 
	 
	 	 	 	 	 	 	 	 
	/s/
 

Roger B. Collins, Director

	 	 	 	 	 	 	 	 

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	/s/
 

Peter A. Conrad, Director

	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	/s/
 

Steven F. Cunningham, Director

	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	/s/
 

Jane Garcia, Director

	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	/s/
 

William F. Hampel, Director

	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	/s/
 

Kathleen M. Luzik, Director

	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	/s/
 

Alfred A. Plamann, Director

	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	/s/
 

Kenneth A. Rivkin, Director

	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	/s/
 

Stuart M. Saft, Director

	 	 	 	 	 	 	 	 

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Exhibit 10.1

COLLABORATION AND LICENSE AGREEMENT

     This Collaboration and License Agreement (this “Agreement”) is entered into as of August 27,
2009 (the “Signing Date”), by and between Facet Biotech Corporation, a Delaware corporation having
a principal place of business at 1500 Seaport Blvd., Redwood City, California 94063 (“Facet”) and
Trubion Pharmaceuticals, Inc., a Delaware corporation having a principal place of business at 2401
4th Avenue, Suite 1050, Seattle, Washington 98121 (“Trubion”). Facet and Trubion may each be
referred to herein individually as a “Party” and collectively as the “Parties”.

     WHEREAS, Facet and Trubion are engaged in the research and development of pharmaceutical
products;

     WHEREAS, Trubion has developed a proprietary compound known as TRU-016 directed at the CD37
Antigen (as defined below) and shall initially manufacture such compound for the collaboration; and

     WHEREAS, Facet and Trubion desire to collaborate on the research, development and
commercialization of products directed at the CD37 Antigen (as defined below) as provided herein.

     NOW THEREFORE, in consideration of the mutual promises and covenants set forth below and other
good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the
Parties hereby agree as follows:

1. DEFINITIONS.

     1.1 “AAA” has the meaning set forth in Section 15.3.

     1.2 “Acquired Party” has the meaning set forth in Section 7.3.

     1.3 “Affiliate(s)” means, with respect to any Person, any other Person which controls, is
controlled by or is under common control with such Person for so long as such control exists. For
the purposes of this definition, the word “control” (including, with correlative meaning, the terms
“controlled by” or “under the common control with”) means the actual power, either directly or
indirectly through one or more intermediaries, to direct or cause the direction of the management
and policies of such entity, whether by the ownership of more than fifty percent (50%) of the
voting stock of such entity, or by contract or other means.

     1.4 “Audited Party” has the meaning set forth in Section 9.9(b).

     1.5 “Auditing Party” has the meaning set forth in Section 9.9(b).

     1.6 “Bankrupt Party” has the meaning set forth in Section 14.7.

 

			
	[ * ] =	 	 Certain confidential information contained in this document, marked by brackets, has
been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule
24b-2 of the Securities Exchange Act of 1934, as amended.

 

 

     1.7 “BLA” means a Biologic License Application, as defined in the United States Public Health
Service Act, as amended, and applicable regulations promulgated thereunder by the FDA.

     1.8 “Bulk API” means the active pharmaceutical ingredient form of a Product in bulk form.

     1.9 “Business Day” means a day other than a Saturday, Sunday, or bank or other public holiday
in the State of Washington or California.

     1.10 “Calendar Quarter” means, for each Calendar Year, the respective periods of three (3)
consecutive calendar months ending on March 31, June 30, September 30 or December 31.

     1.11 “Calendar Year” means, for the first calendar year, the period commencing on the Signing
Date and ending on December 31 of the calendar year during which the Signing Date occurs, and each
successive period beginning on January 1 and ending twelve (12) consecutive calendar months later
on December 31.

     1.12 “CD37 Antigen” means the human protein antigen that is known as CD37, and identified as a
full length CD37 protein antigen in GenBank, and identified as of the Signing Date by GenBank
Accession Nos. [ * ].

     1.13 “CD37 Competitor” means a Third Party who is at the applicable time Developing or
Commercializing a protein therapeutic that [ * ] the [ * ] (or [ * ]) [ * ] the [ * ] of [ * ] and
wherein such protein therapeutic is [ * ] or [ * ] or being [ * ] to [ * ] through [ * ] to the [ *
] (or [ * ]).

     1.14 “Change of Control” means, with respect to a Party: (i) the sale of all or substantially
all of such Party’s assets or business relating to this Agreement; (ii) a merger, reorganization,
or consolidation involving such Party in which the voting securities of such Party outstanding
immediately prior thereto cease to represent at least fifty percent (50%) of the combined voting
power of the surviving entity immediately after such merger, reorganization, or consolidation; or
(iii) a Person or group of Persons, acting in concert acquire more than fifty percent (50%) of the
voting equity or management control of such Party.

     1.15 “CHMP” means the Committee for Medicinal Products for Human Use that is responsible for
preparing the opinions on all questions concerning medicinal products for human use for the
European Medicines Agency, or any successor thereto.

     1.16 “Clinical Costs” means all costs incurred by or on behalf of a Party that are directly
attributable and reasonably allocated to the conduct of Clinical Trials of a Collaboration Product,
or Clinical Trials of a [ * ] that were [ * ] to the [ * ] to the extent that such costs [ * ] the
[ * ] for in the [ * ] that was [ * ] on the [ * ], in the Field in the Territory, whether alone or
in combination with another product or agent. [ * ], Clinical Costs shall consist of the following:
(a) the preparation for and conduct of Clinical Trials (except for related Manufacturing Costs
otherwise included in Development Costs); (b) data collection and analysis, and report writing; and
(c) clinical laboratory work. Notwithstanding the above, Clinical Costs shall exclude costs

 

			
	[ * ] =	 	 Certain confidential information contained in this document, marked by brackets, has been omitted
and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

2

 

incurred in connection with Phase IV Clinical Studies for purposes other than label expansion
and Regulatory Approval, and post-marketing surveillance activities, which shall be considered
Sales and Marketing Costs. Clinical Costs shall be calculated in accordance with GAAP,
consistently applied with allocations by a Party calculated in accordance with a methodology [ * ]
(which methodology shall be consistent with GAAP) and based upon [ * ] by [ * ] (i.e., not to [ * ]
costs to [ * ] of [ * ] when [ * ] to costs for [ * ] by [ * ]).

     1.17 “Clinical Trial” means any human clinical trial of a Product.

     1.18 “Collaboration” has the meaning set forth in Section 2.1.

     1.19 “Collaboration Inventions” has the meaning set forth in Section 10.1(a).

     1.20 “Collaboration Product” means a Product with respect to which neither Party has exercised
the Opt-Out Option, nor has been deemed to have exercised its Opt-Out Option under Section 14.2(b).

     1.21 “Combination Product” means any product containing as active ingredients both (a) a
Royalty Product and (b) one or more other pharmaceutically active compounds or substances.

     1.22 “Commercialization Budget” means the budget of Commercialization Costs set forth in the
Commercialization Plan to be incurred by the Parties in connection with the performance of the
Commercialization Plan.

     1.23 “Commercialization Costs” means all costs incurred by or on behalf of a Party in
performing its obligations under the then-current Commercialization Plan that are directly
attributable and reasonably allocated to the Commercialization of a Collaboration Product in the
Field in the Territory. [ * ], Commercialization Costs shall consist of: (a) Manufacturing Costs
for a Collaboration Product for commercial sale; (b) Sales and Marketing Costs; (c) costs
associated with Medical Education Activities incurred after the First Commercial Sale of the
applicable Collaboration Product, and other ancillary services to the foregoing; (d) Distribution
Costs; (e) subject to Section 8.7, payment to a Third Party under a Future Third Party License
incurred after the First Commercial Sale of the applicable Collaboration Product; (f) Trademark
Costs incurred after the First Commercial Sale of the applicable Collaboration Product; (g) patent
costs described in Section 10.3(b)(i); and (h) patient assistance and indigent/expanded access
programs with respect to a Collaboration Product. Commercialization Costs shall specifically
exclude general corporate and administrative overhead of each Party. In the calculation of
Commercialization Costs, a Party’s FTE effort shall be calculated at the FTE Rate.
Commercialization Costs shall be calculated in accordance with GAAP, consistently applied with
allocations by a Party calculated in accordance with a methodology [ * ] (which methodology shall
be consistent with GAAP) and based upon [ * ] by [ * ] (i.e., not to [ * ] costs to [ * ] of [ * ]
when [ * ] to [ * ] costs for [ * ] of [ * ]).

     1.24 “Commercialization Plan” means the written plan for the Commercialization of a
Collaboration Product described in Section 5.2.

 

			
	[ * ] =	 	 Certain confidential information contained in this document, marked by brackets,
has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

3

 

     1.25 “Commercialize” means to promote, market, distribute, sell (and offer for sale or
contract to sell) or provide product support for a Product, including by way of example: (a)
detailing and other promotional activities in support of a Product; (b) advertising and public
relations in support of a Product, including market research, development and distribution of
selling, advertising and promotional materials, field literature, direct-to-consumer advertising
campaigns, media/journal advertising, and exhibiting at seminars and conventions; (c) developing
reimbursement programs and information and data specifically intended for national accounts,
managed care organizations, governmental agencies (e.g., federal, state and local), and other group
purchasing organizations, including pull-through activities; (d) conducting Medical Education
Activities and journal advertising; and (e) conducting Phase IV Clinical Studies for purposes other
than label expansion and Regulatory Approval, and post-marketing surveillance activities. For
clarity, “Commercializing” and “Commercialization” have a correlative meaning.

     1.26 “Commercial Supply Agreement” has the meaning set forth in Section 6.5.

     1.27 “Committee” means the JSC, the JDC, the JCC, the JFC, the JPC, or any other committee
established by the JSC in accordance with the terms of this Agreement.

     1.28 “Competing Program” has the meaning set forth in Section 8.5.

     1.29 “Confidential Information” of a Party means all Know-How or other information, including,
without limitation, proprietary information and materials (whether or not patentable) regarding
such Party’s technology, products, business information or objectives, that is communicated in any
way or form by such Party to the other Party pursuant to this Agreement, and that is identified as
confidential at the time of disclosure; provided that, information not identified as confidential
by the disclosing Party shall be deemed to be Confidential Information of the disclosing Party if
the receiving Party knows, or should have had a reasonable expectation, that such information
communicated by the disclosing Party is confidential or proprietary information of the disclosing
Party. Notwithstanding the foregoing, all Know-How and information [ * ] by [ * ] in the [ * ] of
[ * ] and [ * ] under [ * ] shall be deemed Confidential Information of [ * ]. All confidential
information disclosed by either Party pursuant to that certain Mutual Non-Disclosure Agreement
between the Parties dated December 22, 2008 (the “Non-Disclosure Agreement”) that is related to the
subject matter of this Agreement shall be deemed to be such Party’s Confidential Information
hereunder. The terms and conditions of this Agreement shall be considered Confidential Information
of both Parties.

     1.30 “Consolidated Party” and “Consolidation Party” shall have the respective meanings set
forth in Section 9.9(e).

     1.31 “Control” or “Controlled” means, with respect to any item of Know-How, Patent Rights, or
other intellectual property right, the possession (whether by ownership or license, other than a
license granted by one Party to the other pursuant to this Agreement) by a Party of the ability to
grant to the other Party access, a license or a sublicense (as applicable), or to extend other
rights as provided in this Agreement, to such intellectual property right, without violating the
terms of any agreement or other arrangements with any Third Party existing at the

 

			
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has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

4

 

time such Party would be first required to grant any such access, license or sublicense under
this Agreement.

     1.32 “Co-Commercialization” means the joint Commercialization of a Collaboration Product in
the Field, in the Territory by both Parties under the terms of this Agreement. “Co-Commercialize,”
when used as a verb, means to engage in such Co-Commercialization.

     1.33 “Co-Development” means the joint Development of a Collaboration Product in the Field, in
the Territory by both Parties under the terms of this Agreement. “Co-Develop,” when used as a
verb, means to engage in such Co-Development.

     1.34 “Detail” or “Detailing” means an interactive presentation (whether face-to-face or via
live videoconferencing, including over the Internet) by a Party’s sales representative, to one or
several medical professional(s) having prescribing authority in the applicable territory in the
Field, as well as to other mutually agreed individuals or entities that have the ability to impact
or influence prescribing decisions in the applicable territory in the Field, where the principal
objective of such presentation is to emphasize the features and function of such Collaboration
Product in the Field in compliance with applicable Laws. A Detail does not include a reminder or
sample drop or a non-interactive webcast or similar presentation.

     1.35 “Development” or “Develop” means research, pre-clinical and clinical drug development
activities pertaining to a Product, including, without limitation, toxicology, pharmacology, test
method development, stability testing, process development, formulation development, delivery
system development, quality assurance and quality control development, statistical analysis,
clinical studies (including pre- and post-approval studies), regulatory affairs, pharmacovigilance
and Regulatory Approval and clinical study regulatory activities (including regulatory activities
directed to obtaining pricing and reimbursement approvals). Development shall include development
and regulatory activities for additional indications for a Product after Regulatory Approval of
such Product, but shall exclude Phase IV Clinical Studies for purposes other than label expansion
and Regulatory Approval and post-marketing surveillance activities.

     1.36 “Development Budget” means the budget for Development Costs set forth in the Development
Plan which shall include a detailed budget for the first year thereof, which budget shall be
allocated between the Parties on a [ * ] basis, and a forecast for the subsequent [ * ] years.

     1.37 “Development Costs” means the costs incurred by or on behalf of a Party in performing its
obligations under the then-current Development Plan, that are directly attributable and reasonably
allocated to the Development of a Collaboration Product, or Clinical Trials of a [ * ] that were [
* ] to the [ * ] to the extent that such costs [ * ] the [ * ] for in the [ * ] that was [ * ] on
the [ * ], in the Field in the Territory, and that are directed to achieving or maintaining
Regulatory Approval of such Collaboration Product or Royalty Product. The Development Costs shall
include amounts, without mark-up, that a Party pays to Third Parties involved in such Development
of a Collaboration Product, and all internal costs incurred by a Party in connection with such
Development of such Collaboration Product. [ * ], Development Costs include the following: (a)
preclinical costs, such as toxicology and the creation of product assays such as those for
pharmacokinetic and immunogenicity testing; (b) formulation development, process

 

			
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has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

5

 

development, test method development, delivery system development, stability testing and
statistical analysis; (c) Clinical Costs; (d) costs associated with Medical Education Activities
incurred prior to the First Commercial Sale of the applicable Collaboration Product, and other
ancillary services to the foregoing, (e) Manufacturing Costs for a Collaboration Product for use in
preclinical and clinical activities including the manufacture, purchase or packaging of comparators
or placebo for use in Clinical Trials of a Collaboration Product (with the manufacturing costs for
comparators or placebo to be determined in the same manner as Manufacturing Costs are determined
for any Collaboration Product), as well as the direct costs and expenses of disposal of drugs and
other supplies used in such clinical studies; (f) subject to Section 8.7, payment to a Third Party
under a Future Third Party License incurred prior to the First Commercial Sale of the applicable
Collaboration Product; (g) losses incurred in connection with claims set forth in Section 13.5, to
the extent provided therein; (h) development of the Manufacturing process for a Collaboration
Product (including with respect to any excipients or adjuvants included in such Collaboration
Product) and related scale-up, manufacturing process validation, manufacturing process
improvements, and qualification and validation of Third Party contract manufacturers; (i)
regulatory expenses relating to Development activities for the purpose of obtaining Regulatory
Approval for an indication for a Collaboration Product; (j) patent costs described in Section
10.3(b)(i); (k) Trademark Costs incurred prior to the First Commercial Sale of the applicable
Collaboration Product; and (l) other out-of pocket Collaboration Product Development expenses that
meet the criteria set forth above in this Section 1.37 including, without limitation institutional
and advisory review boards, investigator meetings, quality of life studies, epidemiology and
outcomes research. For clarity, scale-up and validation costs as described in clause (h) above will
be considered Development Costs until commercial Collaboration Product that is eligible for sale
has been manufactured. Development Costs shall specifically exclude general corporate and
administrative overhead of each Party. In the calculation of Development Costs, a Party’s FTE
effort shall be calculated at the FTE Rate. Development Costs shall be calculated in accordance
with GAAP, consistently applied with allocations by a Party calculated in accordance with a
methodology [ * ] (which methodology shall be consistent with GAAP) and based upon [ * ] by [ * ]
(i.e., not to [ * ] costs to [ * ] of [ * ] when [ * ] to [ * ] costs for [ * ] of [ * ]).

     1.38 “Development Plan” means the written plan for the Development of a Collaboration Product
described in Section 3.3.

     1.39 “Diligent Efforts” means, with respect to the efforts to be expended by any Party with
respect to any objective, those [ * ], [ * ], [ * ] efforts to accomplish such objective as such
Party would [ * ] use to accomplish a [ * ] under [ * ]. With respect to any objective relating to
the Development and/or Commercialization of a Product by any Party, “Diligent Efforts” means those
efforts and resources [ * ] by [ * ] with respect to a [ * ] or [ * ] by [ * ] which [ * ] is [ * ]
in its [ * ] or [ * ] and is of [ * ] in the [ * ] taking into account [ * ], [ * ], [ * ], the [ *
] of all [ * ] in the [ * ], the [ * ] and other [ * ] of the [ * ], the [ * ] of [ * ] given the [
* ] involved, the [ * ] of the [ * ] including the [ * ] to [ * ] of [ * ] or other [ * ], [ * ]
and other relevant factors. Diligent Efforts shall be determined on a [ * ] and [ * ] basis for a
particular [ * ], and it is anticipated that the [ * ] of [ * ] shall be [ * ] for [ * ], and shall
[ * ], reflecting [ * ] in the [ * ] of the [ * ] and the [ * ] involved. Diligent Efforts
requires a Party to: (a) [ * ] for such [ * ] to specific [ * ] who are [ * ] for the [ * ] and [ *
] such [ * ] on an [ * ] basis, (b) [ * ] and [ * ] to [ * ] and [ * ] for [ * ] such [ * ], and
(c) [ * ] and [ * ] and [ * ] to [ * ] with respect to such [ * ].

 

			
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     1.40 “Distribution Costs” means the costs, excluding general corporate and administrative
overhead, incurred by or on behalf of a Party that are directly attributable and reasonably
allocated to the distribution of a Collaboration Product in the Field in the Territory for
Commercialization purposes, including, unless otherwise determined by the JSC: (a) handling and
transportation to fulfill orders with respect to a Collaboration Product in the Territory to the
extent such costs are not included in one or more items listed in Section 1.92 (a)-(d); (b)
customer services, including order entry, billing and adjustments, inquiry and credit and
collection with respect to a Collaboration Product in the Territory; and (c) costs of storage and
distribution of Collaboration Products for sale in the Territory. Distribution Costs shall be
calculated in accordance with GAAP, consistently applied with allocations by a Party calculated in
accordance with a methodology [ * ] (which methodology shall be consistent with GAAP) and based
upon [ * ] by [ * ] (i.e., not to [ * ] costs to [ * ] of a [ * ] when [ * ] to [ * ] costs for [ *
] of [ * ]).

     1.41 “Dollars” or “$” means the legal tender of the United States.

     1.42 “Drug Approval Application” means a NDA, BLA, or any MAA.

     1.43 “End-of-Phase 2 Meeting” means a meeting with FDA, the purpose of which is to determine
the safety of initiating a first Phase III Clinical Study, to evaluate the Phase III Clinical Study
plan and protocols and the adequacy of current studies and plans to assess pediatric safety and
effectiveness, and to identify any additional information necessary to support a Drug Approval
Application for the uses under investigation, as further defined in 21 C.F.R. 312.47(b)(1), as
amended from time to time, or the corresponding foreign equivalent.

     1.44 “European Union” or “EU” means all of the European Union member states as of the
applicable time during the Term.

     1.45 “Executive Officers” means the Chief Executive Officer of Facet (or an executive officer
of Facet designated by such Chief Executive Officer) and the Chief Executive Officer of Trubion (or
an executive officer of Trubion designated by such Chief Executive Officer).

     1.46 “Existing Inventory” has the meaning set forth in Section 7.5(b)(vi).

     1.47 “Facet Applied Know-How” means the Facet Know-How applied, [ * ] the [ * ] or the [ * ]
of [ * ] of [ * ] by [ * ] under Section [ * ] or by [ * ] under Section [ * ], as applicable, or [
* ] the [ * ] or the [ * ] of [ * ], as applicable, to the extent [ * ] of Facet Know-How was [ * ]
in the [ * ] of the [ * ] or the [ * ], as applicable, to the Development, Manufacture, use,
importation or Commercialization of (a) in the case of an Opt-Out, a Royalty Product in the Field
that, [ * ] the [ * ], is in [ * ] or is being [ * ] in the [ * ], or (b) in the case of a
termination of this Agreement by [ * ] under Section [ * ] or by [ * ] under Section [ * ], a
Product in the Field that, [ * ] the [ * ] of [ * ], is in [ * ] or is being [ * ] in the [ * ].

     1.48 “Facet Applied Patent Rights” means the Facet Patent Rights that claim [ * ], [ * ] or [
* ], or that would otherwise be infringed, absent a license, by [ * ], [ * ] or [ * ] (a) in the
case of an Opt-Out, a Royalty Product in the Field that, [ * ] the [ * ], is in [ * ] or is being [
* ] in the [ * ], as such Royalty Product [ * ] of such [ * ] or, for a Royalty Product in [ * ],
is [ * ] as [ *

 

			
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has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

7

 

] in the [ * ] of the [ * ], or (b) in the case of a termination of this Agreement by [ * ]
under Section [ * ], a Product that, [ * ] the [ * ] of [ * ], is in [ * ] or is being [ * ] in the
[ * ], as such Product [ * ] of such [ * ], or, for a Product in [ * ], is [ * ] as [ * ] in the [
* ] of the [ * ] of [ * ].

     1.49 “Facet Applied Technology” means the Facet Applied Know-How and Facet Applied Patent
Rights.

     1.50 “Facet Collaboration Patent Rights” means Facet Patent Rights that (a) claim a
Collaboration Invention generated solely by Facet, or its Affiliate(s), including through their
employees, agents or independent contractors, and (b) are not Facet Product Patent Rights.

     1.51 “Facet Know-How” means any Know-How that (a) is a [ * ] by Facet, or its Affiliate(s),
including through their employees, agents or independent contractors, or is otherwise [ * ] by
Facet and/or its Affiliate(s); and (b) is [ * ] for the Development, Manufacture, use, importation
or Commercialization of Products in the Field. For clarity, the use of “Affiliate” in this
definition shall exclude any Third Party that becomes an Affiliate due to a Third Party’s
acquisition of Facet, except as provided in Section 16.1.

     1.52 “Facet Patent Right” means a Patent Right that (a) claims a [ * ] by Facet, or its
Affiliate(s), including through their employees, agents or independent contractors, or is Facet’s [
* ] in a [ * ] or is otherwise [ * ] by Facet and/or its Affiliates; and (b) claims the [ * ] or [
* ] one or more Products in the Field or that would otherwise be infringed, absent a license, by
the [ * ] or [ * ] any Products in the Field. For clarity, the use of “Affiliate” in this
definition shall exclude any Third Party that becomes an Affiliate due to a Third Party’s
acquisition of Facet, except as provided in Section 16.1.

     1.53 “Facet Product Patent Rights” means those Facet Patent Rights that claim the [ * ], [ * ]
or [ * ] one or more Products in the Field, and do not claim the [ * ], [ * ] or [ * ] of any [ * ]
that is [ * ].

     1.54 “FDA” means the United States Food and Drug Administration or any successor agency
thereto.

     1.55 “FD&C Act” means the United States Federal Food, Drug, and Cosmetic Act (21 U.S.C. § 301
et seq.), as amended, and the rules and regulations promulgated thereunder.

     1.56 “Field” means all human and animal applications.

     1.57 “First Commercial Sale” means, with respect to a given Product in the Field and any
country in the Territory, the first sale or transfer for value of such Product under this Agreement
by either Party or its Affiliates or permitted sublicensees to a Third Party for end use or
consumption in such country following receipt of Regulatory Approval from the appropriate
Regulatory Authority permitting commercial sale of such Product in such country. First Commercial
Sale excludes any sale or other distribution for use in a Clinical Trial or other Development
activities.

     1.58 “FTE” means the equivalent of a full-time individual’s work, currently [ * ] hours per
year for a twelve (12) month period, on Development or Commercialization of Collaboration

 

			
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has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2
of the Securities Exchange Act of 1934, as amended.

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Products. In the case that any full time personnel of a Party works partially on the
Development or Commercialization of Collaboration Products and partially on other work outside this
Agreement in a given fiscal year, then the full-time equivalent to be attributed to such
individual’s work hereunder shall be equal to the percentage of such individual’s total work time
in such fiscal year that such individual spent working on activities related to the Development or
Commercialization of Collaboration Products. In the event that any part-time personnel of a Party
works on the Development or Commercialization of Collaboration Products, the full time equivalent
to be attributed to such work shall reflect appropriate adjustment for such personnel’s reduced
total work time relative to full time personnel. FTE efforts shall not include general corporate
and administrative overhead. Each Party shall track FTEs using its standard practice and normal
systems and methodologies as approved by the JFC.

     1.59 “FTE Rate” means the partially burdened FTE personnel cost incurred by a Party, which for
purposes of this Agreement shall initially be set at an annual rate of [ * ] per FTE. Commencing
with the Calendar Year [ * ], the FTE Rate shall be [ * ] by [ * ].

     1.60 “Future Third Party License” has the meaning set forth in Section 8.7.

     1.61 “GAAP” means United States generally accepted accounting principles, consistently
applied, in accordance with the rules and guidance of the United States Securities and Exchange
Commission.

     1.62 “Good Clinical Practices” or “GCP” means the then-current good clinical practice
standards, practices and procedures promulgated or endorsed by FDA as set forth in the guidelines
entitled “Guidance for Industry E6 Good Clinical Practice: Consolidated Guidance,” including
related regulatory requirements imposed by FDA, and comparable regulatory standards, practices and
procedures in jurisdictions outside the United States, in each case as they may be updated from
time to time.

     1.63 “Good Laboratory Practices” or “GLP” means the then-current good laboratory practice
standards promulgated or endorsed by FDA as defined in 21 C.F.R. Part 58, and comparable regulatory
standards in jurisdictions outside the United States, in each case as they may be updated from time
to time.

     1.64 “Good Manufacturing Practices” or “GMP” means the then-current good manufacturing
practices required by FDA, as set forth in the FD&C Act and the regulations promulgated thereunder,
for the manufacture and testing of pharmaceutical materials, and comparable Laws applicable to the
manufacture and testing of pharmaceutical materials in jurisdictions outside the United States,
including without limitation the guideline promulgated by the International Conference on
Harmonization designated ICH Q7A, entitled “Q7A Good Manufacturing Practice Guidance for Active
Pharmaceutical Ingredients” and the regulations promulgated thereunder, in each case as they may be
updated from time to time.

     1.65 “Governmental Authority” means any multi-national, federal, state, local, municipal or
other government authority of any nature (including any governmental division, subdivision,
department, agency, bureau, branch, office, commission, council, court or other tribunal).

 

			
	[ * ] =	 	 Certain confidential information contained in this document, marked by brackets,
has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

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     1.66 “ICH” has the meaning set forth in Section 4.7.

     1.67 “IND” means an Investigational New Drug Application, as defined in the FD&C Act, that is
required to be filed with FDA before beginning clinical testing of a Product in human subjects, or
an equivalent foreign filing.

     1.68 “Initial Development Plan” has the meaning set forth in Section 3.3(b).

     1.69 “Joint Commercialization Committee” or “JCC” has the meaning set forth in Section 2.1(a).

     1.70 “Joint Development Committee” or “JDC” has the meaning set forth in Section 2.1(a).

     1.71 “Joint Finance Committee” or “JFC” has the meaning set forth in Section 2.1(a).

     1.72 “Joint Invention” has the meaning set forth in Section 10.1(c).

     1.73 “Joint Patent Committee” or “JPC” has the meaning set forth in Section 2.1(a).

     1.74 “Joint Patent Right” means a Patent Right that claims a Joint Invention.

     1.75 “Joint Steering Committee” or “JSC” has the meaning set forth in Section 2.1(a).

     1.76 “Know-How” means any data, results, and information of any type whatsoever, in any
tangible or intangible form, including, without limitation, know-how, trade secrets, practices,
techniques, methods, processes, inventions, developments, specifications, formulations, formulae,
materials or compositions of matter of any type or kind (patentable or otherwise), software,
algorithms, marketing reports, clinical and non-clinical study reports, regulatory submission
summaries and regulatory submission documents, expertise, technology, test data including
pharmacological, biological, chemical, biochemical, toxicological, and clinical test data,
analytical and quality control data, stability data, studies and procedures.

     1.77 “Laws” means all relevant laws, statutes, rules, regulations, guidelines, ordinances and
other pronouncements having the effect of law of any federal, national, multinational, state,
provincial, county, city or other political subdivision, domestic or foreign.

     1.78 “Lead Commercialization Party” has the meaning set forth in Section 5.1.

     1.79 “Lead Development Party” has the meaning set forth in Section 3.2.

     1.80 “Lead Manufacturing Party” has the meaning set forth in Section 6.1.

     1.81 “Lead Regulatory Party” has the meaning set forth in Section 4.1.

     1.82 “Major European Countries” means [ * ], and the [ * ].

 

			
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has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

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     1.83 “Major Market Countries” means the United States, [ * ] Major European Countries, and [ * ].

     1.84 “Manufacturing” or “Manufacture” means activities directed to producing, manufacturing,
processing, filling, finishing, packaging, labeling, quality assurance testing and release,
shipping and storage of a Product.

     1.85 “Manufacturing Costs” means the costs incurred by or on behalf of a Party that are
directly attributable and reasonably allocated to the Manufacturing of Collaboration Products. [ *
], Manufacturing Costs shall consist of (a) if the Collaboration Product is manufactured by a Third
Party manufacturer, (i) a Party’s [ * ] cost (expressed in the case of [ * ] on a [ * ] basis) of
manufacturing, processing, testing, filling, finishing, packaging and labeling such Collaboration
Product, and (ii) any costs incurred by such Party for [ * ] and [ * ] in accordance with the
Development Plan or the Commercialization Plan, as applicable; or (b) if the Collaboration Product
is manufactured by a Party, the [ * ] cost of manufacturing, processing, testing, filling,
finishing, packaging and labeling such Collaboration Product, including without limitation raw
materials, direct labor and benefits, and the [ * ] of [ * ]. For clarity, the [ * ] cost
referenced under subsection (b) above shall be calculated on a [ * ] basis (with reasonable [ * ]
and [ * ]) with the [ * ] to [ * ] representing the [ * ] of [ * ] or [ * ] of [ * ] or [ * ] as a
[ * ] of the [ * ] of [ * ] or [ * ], including those of [ * ], that [ * ] in [ * ] during a [ * ].
Manufacturing Costs shall be calculated in accordance with GAAP, consistently applied with
allocations by a Party calculated in accordance with a methodology [ * ] (which methodology shall
be consistent with GAAP) and based upon [ * ] by [ * ] (i.e., not to [ * ] costs to [ * ] of [ * ]
when compared to [ * ] costs for [ * ] of [ * ].

     1.86 “Marketing Authorization Application” or “MAA” means an application for Regulatory
Approval (but excluding Pricing Approval) in any particular jurisdiction other than the United
States.

     1.87 “Marks” means trade marks, service marks, trade names, service names, logos, slogans, tag
lines, trade dress, and Internet domain names and addresses.

     1.88 “Medical Education Activities” means activities designed to ensure or improve appropriate
medical use of, conduct medical education of, or further research regarding, a Collaboration
Product sold or to be sold in the Territory, including by way of example: (a) activities of medical
sales liaisons; (b) grants to support continuing medical education, symposia, or research related
to a Collaboration Product in the Territory (excluding Phase IV Clinical Studies, which, with
respect to a Collaboration Product, shall be considered Sales and Marketing Costs if conducted for
a purpose other than label expansion or Regulatory Approval and otherwise shall be considered
Development Costs); (c) development, publication and dissemination of publications relating to a
Collaboration Product in the Territory, as well as medical information services provided in
response to inquiries communicated via sales representatives or received by letter, phone call or
email; and (d) conducting advisory board meetings or other consultant programs, the purpose of
which is to obtain advice and feedback related to the Development or Commercialization of a
Collaboration Product in the Territory.

     1.89 “Milestone Payment” has the meaning set forth in Section 9.3.

 

			
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     1.90 “Multi-Specific Product” means a SMIP or other protein therapeutic that binds to the CD37
Antigen (or a portion thereof) and binds to one or more additional biological targets that are not
part of the CD37 Antigen, in each case [ * ] of [ * ] and wherein such SMIP or protein therapeutic
is [ * ] or [ * ] or [ * ] to [ * ] a [ * ] through [ * ] the [ * ] (or a [ * ]) and a [ * ]
through [ * ] the [ * ].

     1.91 “NDA” means a New Drug Application, as defined in the FD&C Act and the regulations
promulgated thereunder by the FDA.

     1.92 “Net Sales” means all amounts invoiced on sales of Royalty Products by a Party, its
Affiliates or permitted sublicensees to Third Parties, less the following deductions actually
allowed or taken by such Third Parties and not otherwise recovered by or reimbursed to the seller
whose sales are being measured:

          (a) trade, quantity or volume, and cash discounts, including amounts paid or credited to
customers under distribution and channel services agreements;

          (b) credits, rebates and chargebacks (including those to managed-care entities and government
agencies), allowances for bad debt not to exceed [ * ] and allowances to customers on account of
rejection or returns or retroactive price reductions;

          (c) freight, postage and transportation charges, including handling and insurance to the
extent added to the sales price and set forth separately as such in the total amount invoiced; and

          (d) sales (such as VAT or its equivalent) and excise taxes, other consumption taxes and
customs duties to the extent added to the sales price and set forth separately as such in the total
amount invoiced.

Sales between a Party and its Affiliates or permitted sublicensees for resale shall be excluded
from the computation of Net Sales. In any other sale of Royalty Products that is made on other
than arms’-length terms, the amounts invoiced shall be deemed, for purposes of this definition, to
be no less than the amount that would be invoiced in a substantially contemporaneous, arms’-length
transaction.

In the event a Royalty Product is sold in a country as part of a Combination Product, for purposes
of determining payments due a Party under this Agreement, Net Sales of Combination Products shall
be calculated by multiplying the Net Sales of the Combination Product by the fraction A over A+B,
in which A is the Gross Selling Price of the Royalty Product when such Royalty Product is sold in
the relevant country in substantial quantities where the Royalty Product is the sole
therapeutically active ingredient during the applicable accounting period in which the sales of the
Royalty Product were made, and B is the Gross Selling Price of the other therapeutically active
ingredients contained in the Combination Product sold separately in the relevant country in
substantial quantities during the accounting period in question. All Gross Selling Prices of the
therapeutically active ingredients of the Royalty Product and Combination Products shall be
calculated as the average Gross Selling Price of the therapeutically active ingredients in such
products in the relevant country during the applicable accounting period for which the Net Sales
are being calculated. In the event that no separate sale of either the Royalty

 

			
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has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

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Product as the sole therapeutically active ingredient or the other therapeutically active
ingredients of the Combination Product are made in the relevant country during the accounting
period in which the sale was made or if the Gross Selling Price for a particular therapeutically
active ingredient cannot be determined for an accounting period, Net Sales allocable to the Royalty
Product and Combination Product shall be determined by mutual agreement reached in good faith by
the Parties prior to the end of the accounting period in question based on an equitable method of
determining same that takes into account the relative contribution of each therapeutically active
ingredient in the Combination Product, and relative value to the end user of each therapeutically
active ingredient. For purposes of this definition, “Gross Selling Price” means the gross price at
which an active ingredient is sold to a Third Party, before discounts, deductions, credits, taxes
or allowances.

     1.93 “Non-Clinical Studies” means all non-human studies of Products.

     1.94 “Non-Opt-Out Party” means the Party which receives an Opt-Out Notice pursuant to Section
7.2, 7.3 or 8.5 or provides a written notice of continuation to the breaching Party pursuant to
Section 14.2(b).

     1.95 “Opt-Out Effective Date” has the meaning set forth in Section 7.4.

     1.96 “Opt-Out Notice” has the meaning set forth in Section 7.1.

     1.97 “Opt-Out Option” has the meaning set forth in Section 7.1.

     1.98 “Opt-Out Party” means the Party which has exercised its Opt-Out Option pursuant to
Sections 7.2, 7.3 or 8.5 or which is deemed to have exercised its Opt-Out Option pursuant to
Section 14.2(b).

     1.99 “Opt-Out Product” has the meaning set forth in Section 7.2.

     1.100 “Patent Rights” means any and all (a) patents; (b) pending patent applications,
including, without limitation, all provisional applications, substitutions, continuations,
continuations-in-part, divisions, renewals, and all patents granted thereon, (c) all
patents-of-addition, reissues, reexaminations and extensions or restorations by existing or future
extension or restoration mechanisms, including, without limitation, supplementary protection
certificates or the equivalent thereof, (d) inventor’s certificates, and (e) all United States and
foreign counterparts of any of the foregoing.

     1.101 “Person” means an individual, sole proprietorship, partnership, limited partnership,
limited liability partnership, corporation, limited liability company, business trust, joint stock
company, trust, incorporated association, joint venture or similar entity or organization,
including a government or political subdivision, department or agency of a government.

     1.102 “Pharmacovigilance Agreement” has the meaning set forth in Section 4.12.

     1.103 “Phase I Clinical Study” means a study of a Product in the Field in human subjects with
the endpoint of determining initial tolerance, safety or pharmacokinetic information

 

			
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in single dose, single ascending dose, multiple dose and/or multiple ascending dose regimens,
which is prospectively designed to generate sufficient data (if successful) to commence a Phase II
Clinical Study of such Product, as further defined in 21 C.F.R. 312.21(a), as amended from time to
time, or the corresponding foreign regulations.

     1.104 “Phase II Clinical Study” means a study of a Product in the Field in human patients to
determine initial efficacy and dose range and/or regimen finding before embarking on Phase III
Clinical Studies, as further defined in 21 C.F.R. 312.21(b), as amended from time to time, or the
corresponding foreign regulations.

     1.105 “Phase III Clinical Study” means a pivotal study (whether or not denominated a “Phase
III” clinical study under applicable regulations) in the Field in human patients with a defined
dose or a set of defined doses of a Product designed to ascertain efficacy and safety of such
Product for the purpose of enabling the preparation and submission of Drug Approval Applications to
the competent Regulatory Authorities in a country of the Territory, as further defined in 21 C.F.R.
312.21(c), as amended from time to time, or the corresponding foreign regulations.

     1.106 “Phase IV Clinical Study” means a product support clinical trial of a Product that is
commenced after receipt of Regulatory Approval in the country where such trial is conducted. A
Phase IV Clinical Study may include epidemiological studies, modeling and pharmacoeconomic studies,
“post-marketing surveillance trials” and investigator-sponsored Clinical Trials studying a Product
that are approved by the JCC and that otherwise fit the foregoing definition.

     1.107 “Pre-BLA Meeting” means a meeting with FDA, the primary purpose of which is to uncover
any major unresolved problems, to identify those studies that the sponsor is relying on as adequate
and well-controlled to establish the drug’s effectiveness, to identify the status of ongoing or
needed studies adequate to assess pediatric safety and effectiveness, to acquaint FDA reviewers
with the general information to be submitted in the marketing application (including technical
information), to discuss appropriate methods for statistical analysis of the data, and to discuss
the best approach to the presentation and formatting of data in the marketing application, as
further defined in 21 C.F.R. 312.47(b)(2), as amended from time to time, or the corresponding
foreign equivalent.

     1.108 “Pricing Approval” means such approval, agreement, determination or governmental
decision establishing prices for the Products that can be charged to consumers and shall be
reimbursed by Governmental Authorities in regulatory jurisdictions where the Governmental
Authorities or Regulatory Authorities approve or determine pricing of pharmaceutical products for
reimbursement or otherwise.

     1.109 “Product” means any SMIP or other protein therapeutic that binds to the CD37 Antigen (or
a [ * ]) [ * ] of [ * ] and wherein such SMIP or protein therapeutic is [ * ] or [ * ] or [ * ] to
[ * ] its [ * ] through [ * ] the [ * ] (or a [ * ]), including without limitation TRU-016 [ * ]
any [ * ] Products.

 

			
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     1.110 “Product Labeling” means (a) the full prescribing information for a Collaboration
Product approved in the Field by the applicable Regulatory Authority, and (b) all labels and other
written, printed or graphic information included in or placed upon any container, wrapper or
package insert used with or for the Collaboration Product in the Field.

     1.111 “Product Profit” means (a) gross sales of Collaboration Products (i.e. all amounts
invoiced on sales of Collaboration Products by a Party or its Affiliates), less (b)
Commercialization Costs, and (c) deductions for items listed in 1.92(a)-(d) to the extent actually
allowed or taken by the Lead Commercialization Party and not otherwise recovered by or reimbursed
to the Lead Commercialization Party. For sake of clarity, Product Profit shall be determined prior
to application of any income taxes.

     1.112 “Promotion” means the marketing and advertising of a Collaboration Product in the
relevant Field in the applicable territory in accordance with the relevant Commercialization Plan,
including medical education, information and communication, market development and medical liaison
activities, but not including Detailing. “Promote,” when used as a verb, means to engage in such
Promotion.

     1.113 “Promotional Materials” means all sales representative training materials and all
written, printed, graphic, electronic, audio or video presentations of information, including,
without limitation, journal advertisements, sales visual aids, formulary binders, reprints, direct
mail, direct-to-consumer advertising, internet postings, broadcast advertisements and sales
reminder aides (for example, note pads, pens and other such items) intended for use or used by or
on behalf of the Parties or their Affiliates or permitted sublicensees in connection with any
Promotion of a Collaboration Product, in the Field, in the Territory (all to the extent applicable
for the Commercialization in the Territory), but excluding Product Labeling.

     1.114 “Pursuit Notice” has the meaning set forth in Section 7.5(b).

     1.115 “Recall” has the meaning set forth in Section 5.10.

     1.116 “Regulatory Approval” means the technical, medical and scientific licenses,
registrations, authorizations and approvals (including, without limitation, approvals of Drug
Approval Applications, supplements and amendments, pre- and post- approvals, Pricing Approvals, and
labeling approvals) of any national, supra-national, regional, state or local regulatory agency,
department, bureau, commission, council or other governmental entity, necessary for the commercial
Manufacture, distribution, marketing, promotion, offer for sale, use, import, export and sale of
Product(s) in a regulatory jurisdiction in the Field, in the Territory. For the sake of clarity,
Regulatory Approval shall [ * ] have been [ * ] in a country [ * ] the [ * ] until any applicable [
* ] have [ * ] in such country. Regulatory Approval of a Product shall [ * ] have been [ * ] in
the [ * ] upon [ * ] of [ * ] for such Product in the [ * ].

     1.117 “Regulatory Authorit(y/ies)” means any national (e.g., FDA), supra-national (e.g., the
European Commission, the Council of the European Union, or the European Agency for the Evaluation
of Medicinal Products); regional, state or local regulatory agency, department, bureau, commission,
council or other governmental entity in each country of the Territory that

 

			
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governs the Regulatory Approval for a Product in the Field in such applicable regulatory
jurisdiction.

     1.118 “Regulatory Exclusivity” means any exclusive marketing rights or data exclusivity rights
conferred by any Regulatory Authority with respect to a Product other than patents, including,
without limitation, rights conferred in the United States under the Hatch-Waxman Act or the FDA
Modernization Act of 1997 (including pediatric exclusivity), or rights similar thereto outside the
United States.

     1.119 “Regulatory Materials” means regulatory applications, submissions, notifications,
registrations, Regulatory Approvals or other submissions made to or with a Regulatory Authority
that are necessary or reasonably desirable in order to Develop, Manufacture, and Commercialize the
Products in a particular country, territory or possession. Regulatory Materials include, without
limitation, INDs, Drug Approval Applications, and amendments and supplements for any of the
foregoing, and applications for Pricing Approvals.

     1.120 “Royalty Period” means the period of time beginning on the date of the First Commercial
Sale of a Royalty Product, in the Field, in a particular country in the Territory and, on a Royalty
Product-by-Royalty Product and country-by-country basis, extending until the later of (i) the date
on which the last Valid Claim included within the Trubion Patent Rights and the Facet Applied
Patent Rights ceases to be a Valid Claim, which Valid Claim would be infringed by [ * ] or [ * ]
such Royalty Product in such country, (ii) the expiration of any Regulatory Exclusivity granted
with respect to such Royalty Product in such country and (iii) the [ * ] year anniversary of the
First Commercial Sale of such Royalty Product in such country.

     1.121 “Royalty Product” means a Product with respect to which a Party has exercised or is
deemed to have exercised the Opt-Out Option and the other Party has provided or is deemed to have
provided a Pursuit Notice in accordance with Section 7.5(b) or 14.2(b).

     1.122 “Sales and Marketing Costs” means the direct costs that are directly attributable and
reasonably allocated to the sales and marketing of a Collaboration Product in Field in the
Territory. [ * ], Sales and Marketing Costs shall consist of: (a) activities directed to the
advertising and marketing of a Collaboration Product in the Territory; (b) professional education
(to the extent not performed by sales representatives), including launch meetings; (c) costs of
advertising, public relations and medical education agencies with respect to a Collaboration
Product in the Territory; (d) peer-to-peer activities with respect to a Collaboration Product in
the Territory, such as continuing medical education, grand rounds, and lunch and dinner meetings;
(e) speaker programs with respect to a Collaboration Product in the Territory, including the
training of such speakers; (f) grants to support continuing medical education or research
(excluding costs associated with Clinical Trials other than Phase IV Clinical Studies for a
Collaboration Product for purposes other than label expansion and Regulatory Approval); (g)
development, publication and dissemination of publications with respect to a Collaboration Product
in the Territory; (h) developing, obtaining and providing training with respect to a Collaboration
Product in the Territory, as well as training packages, promotional literature, promotional
materials and other selling materials with respect to a Collaboration Product in the Territory; (i)
developing and performing market research with respect to a Collaboration Product in the Territory;
(j) conducting symposia and opinion leader development activities with respect

 

			
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to a Collaboration Product in the Territory; (k) developing reimbursement programs with
respect to a Collaboration Product in the Territory; (l) developing information and data
specifically intended for national accounts, managed care organizations and group purchasing
organizations with respect to a Collaboration Product in the Territory; (m) losses incurred in
connection with claims set forth in Section 13.5, to the extent provided therein; (n) costs of
transporting, housing and maintaining sales representatives for training with respect to a
Collaboration Product in the Territory; (o) conducting Phase IV Clinical Studies for Collaboration
Products for purposes other than label expansion and Regulatory Approval; and (p) administration,
operation and maintenance of the sales force that promotes a Collaboration Product in the
Territory, sales bulletins and other communications, sales meetings, specialty sales forces,
consultants, call reporting and other monitoring/tracking costs, district and regional sales
management, home office personnel who support the sales force. Sales and Marketing Costs shall
include costs of such activities that are undertaken at any time during the Term (including prior
to the initial Regulatory Approval of a Collaboration Product in the Territory). Sales and
Marketing Costs shall be calculated in accordance with GAAP, consistently applied with allocations
by a Party calculated in accordance with a methodology [ * ] (which methodology shall be consistent
with GAAP) and based upon [ * ] by [ * ] (i.e., not to [ * ] costs to [ * ] of a [ * ] when
compared to [ * ] costs for [ * ] of [ * ]).

     1.123 “SMIP(s)” or “small modular immuno-pharmaceutical(s)” means a single chain polypeptide
that (i) is [ * ] having [ * ] and [ * ] or a [ * ] of such [ * ], (ii) binds with specificity to a
target antigen, (iii) has a binding domain, and (iv) may have an effector domain which may or may
not have effector function, including, but not limited to, any [ * ] or [ * ] thereof, any [ * ] or
[ * ] thereof, any [ * ] or [ * ] thereof, and any other [ * ] or [ * ].

     1.124 “Subcommittee” has the meaning set forth in Section 2.7(a).

     1.125 “Term” has the meaning set forth in Section 14.1.

     1.126 “Territory” means worldwide.

     1.127 “Third Part(y/ies)” means any Person(s) other than Facet and its Affiliates or Trubion
and its Affiliates.

     1.128 “Trademark Costs” mean the fees and expenses paid to outside counsel and other Third
Parties, direct costs of in-house counsel and filing and maintenance expenses, in each case
incurred in connection with the establishment and maintenance of rights under Marks applicable to
Collaboration Product in the Territory, including costs of trademark filing and registration fees,
actions to enforce or maintain a trademark and other trademark proceedings. Trademark Costs shall
be calculated in accordance with GAAP, consistently applied with allocations by a Party calculated
in accordance with a methodology [ * ] (which methodology shall be consistent with GAAP) and based
upon [ * ] by [ * ] (i.e., not to [ * ] costs of [ * ] to a [ * ] when compared to [ * ] costs for
[ * ] of [ * ]).

     1.129 “Transition Assistance” shall have the meaning set forth in Section 7.5(b)(iii).

     1.130 “TRU-016” means the humanized SMIP directed against the CD37 Antigen that is currently
designated by Trubion as “TRU-016,” as further described on Exhibit A.

 

			
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     1.131 “Trubion Know-How” means any Know-How Controlled as of the Signing Date or thereafter
during the Term by Trubion and/or its Affiliate(s) and [ * ] for the Development, Manufacture, use,
importation or Commercialization of Products in the Field. For clarity, the use of “Affiliate” in
this definition shall exclude any Third Party that becomes an Affiliate due to a Third Party’s
acquisition of Trubion, except as provided in Section 16.1.

     1.132 “Trubion Core Patent Rights” means those Trubion Patent Rights that are not Trubion
Product Patent Rights. As of the Signing Date, the Patent Rights listed in Schedule 1.132
are Trubion Core Patent Rights.

     1.133 “Trubion Patent Rights” means Patent Rights that are Controlled as of the Signing Date
or thereafter during the Term by Trubion and/or its Affiliate(s) (including without limitation
Trubion’s interest in Joint Patent Rights) and that claim [ * ] or [ * ] one or more Products in
the Field or that would otherwise be infringed, absent a license, by the [ * ] or [ * ] any
Products in the Field. For clarity, the use of “Affiliate” in this definition shall exclude any
Third Party that becomes an Affiliate due to a Third Party’s acquisition of Trubion except as
provided in Section 16.1.

     1.134 “Trubion Product Patent Rights” means those Trubion Patent Rights that claim the
composition of matter, manufacture or use of one or more Products in the Field, and do not claim
the composition of matter, manufacture or use of any other product that is not a Product. As of
the Signing Date, the Patent Rights listed in Schedule 1.134 are Trubion Product Patent
Rights.

     1.135 “United States” or “U.S.” means the United States of America and its possessions and
territories.

     1.136 “Valid Claim” means a claim that (a) in the case of any unexpired patent, such claim
shall not have been dedicated to the public, disclaimed, nor held invalid or unenforceable by a
court or government agency of competent jurisdiction in an unappealed or unappealable decision, or
(b) in the case of any patent application, such claim (i) shall not have been cancelled, withdrawn
or abandoned, without being refiled in another application, in the applicable
jurisdiction, (ii) shall not have been finally rejected by an administrative agency or other
governmental action from which no appeal can be taken, and (iii) shall not have been pending
(including in any [ * ]) for more than [ * ] from its filing date. If a claim of a patent
application that ceased to be a Valid Claim under (b) due to the passage of time later issues as
part of a patent described within (a) then it shall again be considered to be a Valid Claim
effective as of the issuance of such patent.

2. COLLABORATION MANAGEMENT.

     2.1 General. The Parties desire and intend to establish a collaboration with respect to the
Development, Manufacture and Commercialization of Collaboration Products in the Field in the
Territory on an exclusive basis under the terms of this Agreement (“Collaboration”). Unless and
until a Party exercises or is deemed to have exercised its Opt-Out Option in respect of one or more
Collaboration Products, each Party shall participate in the clinical development of TRU-016 in the
Field, in the Territory and in the preclinical and clinical development of Collaboration

 

			
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Products other than TRU-016 in the Field, in the Territory pursuant to an agreed-upon
Development Plan with respect to each such Collaboration Product, as further described below. The
Parties shall share equally the costs incurred in connection with the performance of each
Development Plan, as set forth in, and in accordance with, Article 3. The Parties shall
Co-Commercialize such Collaboration Products in the Field and share profits equally, subject to the
payment obligations in Article 9 and the other terms of this Agreement. If either Party elects to
exercise its Opt-Out Option for a Collaboration Product as provided for under Article 7 or Section
8.5, or is deemed to have exercised its Opt-Out Option under Section 14.2(b), and if the other
Party so elects, such other Party shall continue and be solely responsible for the Development,
Manufacturing and Commercialization of such Product at its cost and expense pursuant to Section
7.5(b), and shall have the exclusive right to Develop, Manufacture and Commercialize such Product
as a Royalty Product in the Field in the Territory, subject to payments with respect to such
Royalty Product pursuant to Article 9 and the other terms of this Agreement.

          (a) Role of Committees. Subject to Section 2.1(b) and the other terms and conditions of this
Agreement, the Parties shall establish: five (5) specialized joint committees consisting of: (A)
one to set the goals and strategy and approve the budgets for the Development, Manufacture and
Commercialization of Collaboration Products and to oversee the other committees (such committee,
the “Joint Steering Committee” or “JSC”); (B) one to focus on Development, Manufacturing (for
Development purposes) and Regulatory Approval of Collaboration Products and other regulatory
matters (such committee, the “Joint Development Committee” or “JDC”); (C) one to focus on
Commercialization of Collaboration Products (such committee, the “Joint Commercialization
Committee” or “JCC”); (D) one to focus on financial matters (such committee, the “Joint Finance
Committee” or “JFC”); and (E) one to focus on intellectual property matters (such committee, the
“Joint Patent Committee” or “JPC”). Each Committee shall have the responsibilities and authority
allocated to it in this Article 2 and elsewhere in this Agreement.

          (b) Limitations on the Authority of Committees. Notwithstanding the Committee structure
established pursuant to Section 2.1(a) to oversee the Collaboration, each Party shall retain the
rights, powers and discretion granted to it under this Agreement, and no such rights, powers, or
discretion shall be delegated to or vested in a Committee unless such delegation or vesting of
rights is expressly provided for in this Agreement or the Parties expressly so agree in writing.
Without limiting the generality of the foregoing, no Committee shall have any authority or
jurisdiction to: (i) amend, modify, or waive compliance with this Agreement, any of which shall
require mutual written agreement of the Parties; (ii) interpret this Agreement, or determine
whether or not a Party has met its diligence or other obligations under the Agreement or whether or
not a breach of this Agreement has occurred; (iii) make any decision on any matter that this
Agreement expressly states is an option or election to be made by a Party; (iv) make any
retroactive updates, amendments and modifications to, or waivers of provisions of, a Development
Plan or Commercialization Plan, any of which shall require the mutual agreement of the Parties; or
(v) such other matters as are reserved to the consent, approval, agreement or other decision-making
authority of one or both Parties in this Agreement and that are not required by this Agreement to
be considered by a Committee prior to the exercise of such consent, approval or other
decision-making authority. Notwithstanding the foregoing, neither Party shall be restricted from
bringing before any appropriate Committee for

 

			
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discussion any matter relating to the Collaboration that it believes warrants discussion
between the Parties through the Committees, provided that the consideration of any such matter by
any Committee shall not infringe or limit the exercise of a Party’s right of consent or approval or
other decision-making authority granted to it by this Agreement, nor shall any such consideration,
as contemplated by this sentence, subject any such right of consent or approval or other
decision-making authority to any dispute resolution mechanism provided for in Section 2.7 or
Article 15 or elsewhere in this Agreement.

          (c) Representatives. Each Party shall designate representatives to each Committee as provided
for in Sections 2.2-2.6 below. Each representative may serve on more than one Committee as
appropriate in view of the individual’s expertise.

     2.2 Joint Steering Committee.

          (a) Purpose; Formation. Within [ * ] after the Signing Date, the Parties shall establish a
Joint Steering Committee that shall monitor and coordinate communication regarding the Parties’
performance under this Agreement to Develop, obtain Regulatory Approval for, Manufacture, and
Commercialize Collaboration Products in the Field in the Territory. The JSC shall have only the
powers assigned expressly to it in this Section 2.2 and elsewhere in this Agreement, and the JSC
shall not have any power to amend, modify or waive compliance with this Agreement.

          (b) Composition. Each Party shall initially appoint three (3) representatives to the JSC,
each of whom will be an officer or employee of such Party and will have sufficient seniority within
the applicable Party to make decisions arising within the scope of the JSC’s responsibilities. The
JSC may change its size from time to time by mutual consent of its members. Each Party may replace
its JSC representatives at any time upon written notice to the other Party. The JSC may invite
non-members (including consultants and advisors of a Party who are under an obligation of
confidentiality consistent with this Agreement) to participate in the discussions and meetings of
the JSC, provided that such participants shall have no voting authority at the JSC. The JSC shall
have a chairperson. Each Party shall have the right, on an alternating Calendar Year basis, to
select from among its JSC representatives a representative to serve as the chairperson of the JSC
during such Calendar Year. Such Party shall have the right during such Calendar Year to replace
the chairperson of the JSC with one of its other JSC representatives. The initial chairperson shall
be designated by [ * ]. The role of the chairperson shall be to convene and preside at meetings of
the JSC, to prepare agendas (with due input from the other Party’s representatives), circulate
agendas and to ensure the preparation of meeting minutes, but the chairperson shall have no
additional powers or rights beyond those held by the other JSC representatives.

          (c) Specific Responsibilities. In addition to its overall responsibility for monitoring and
providing a forum to discuss and coordinate the Parties’ activities under this Agreement, the JSC
shall in particular:

               (i) oversee the collaborative activities of the Parties under this Agreement, create and
review the overall strategy for Developing and seeking Regulatory

 

			
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Approval for, Manufacturing, and Commercializing Collaboration Products, in the Field in the
Territory;

               (ii) receive and discuss reports from the JDC, the JCC, the JFC, and the JPC, and provide
guidance thereto, approve the Development Plan(s) (including the Development Budget(s)) and the
Commercialization Plan(s) (including the Commercialization Budget(s)), and any amendments thereto;

               (iii) establish such additional joint subcommittees as it deems necessary to achieve the
objectives and intent of this Agreement;

               (iv) attempt to resolve issues presented to it by, and disputes within, the JDC, the JCC, the
JFC, and the JPC, or any other committee;

               (v) review and approve decisions to terminate Development on any Collaboration Product,
including with respect to specific indications;

               (vi) discuss and decide whether to Develop Collaboration Products (other than TRU-016) and for
which indications;

               (vii) select the Lead Development Party, Lead Regulatory Party, Lead Manufacture Party, and
Lead Commercialization Party, and review and approve any changes thereto;

               (viii) review and approve the manufacturing plan for [ * ] and [ * ] or [ * ] with associated
budget, resource allocation and regulatory plans;

               (ix) review and approve (A) inclusion of any costs not specifically enumerated in the
definitions of Development Costs or Commercialization Costs or any component thereof, and (B) any
costs incurred by a Party that exceed that the portion of the applicable Development Budgets or
Commercialization Budgets allocated to such Party with respect to the relevant Calendar Quarter by
more than [ * ];

               (x) review and approve any changes to the specific responsibilities of the JDC, the JCC, the
JFC, and the JPC;

               (xi) discuss and make determinations regarding material safety issues with respect to the
Collaboration Product; and

               (xii) perform such other functions as appropriate to further the purposes of this Agreement as
allocated to it in writing by the Parties.

          (d) Meetings. Unless the Parties mutually agree in writing to a different frequency, the JSC
shall hold at least [ * ] meetings per year (at least [ * ] of which shall be held in person) on
such dates and at such times each year as it elects. The meetings of the JSC shall alternate
between the Parties’ business locations or as otherwise decided by the JSC. Meetings of the JSC
shall be effective only if at least two (2) representatives of each Party are present or
participating. Each Party shall bear the expense of its respective members’ participation in JSC

 

			
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meetings. The chairperson of the JSC shall be responsible for preparing and issuing minutes of
each such meeting within [ * ] thereafter. Such minutes shall not be finalized until each Party
reviews and confirms the accuracy of such minutes in writing; provided that any minutes shall be
deemed approved unless a member of the JSC objects to the accuracy of such minutes within [ * ]
after the circulation of the minutes by the chairperson of the JSC.

          (e) Decision-Making. The JSC shall act by consensus. The representatives from each Party will
have, collectively, one (1) vote on behalf of that Party. If the JSC cannot reach consensus on an
issue that comes before the JSC and over which the JSC has oversight, then such matter shall be
resolved in accordance with Section 2.7.

     2.3 Joint Development Committee.

          (a) Formation and Composition. Within [ * ] after the Signing Date, the Parties shall
establish a Joint Development Committee that shall oversee the Development and Manufacture (for
Development) of Collaboration Products in Field in the Territory in accordance with the Development
Plans for such Collaboration Products and to coordinate the Development and related Manufacturing
activities of the Parties with respect to such Collaboration Products. Each Party shall initially
appoint three (3) representatives to the JDC, each of whom will be an officer or employee of such
Party and will have knowledge and expertise in the Development or Manufacture of products similar
to the Collaboration Products and sufficient seniority within the applicable Party to make
decisions arising within the scope of the JDC’s responsibilities. The JDC may change its size from
time to time by mutual consent of its members. Each Party may replace its JDC representatives at
any time upon written notice to the other Party. The JDC may invite non-members (including
consultants and advisors of a Party who are under an obligation of confidentiality consistent with
this Agreement) to participate in the discussions and meetings of the JDC, provided that such
participants shall have no voting authority at the JDC. The JDC shall have a chairperson. Each
Party shall have the right, on an alternating Calendar Year basis, to select from among its JDC
representatives a representative to serve as the chairperson of the JDC during such Calendar Year.
Such Party shall have the right during such Calendar Year to replace the chairperson of the JDC
with one of its other JDC representatives. The initial chairperson shall be designated by [ * ].
The role of the chairperson shall be to convene and preside at meetings of the JDC, to prepare
agendas (with due input from the other Party’s representatives), circulate agendas and to ensure
the preparation of meeting minutes, but the chairperson shall have no additional powers or rights
beyond those held by the other JDC representatives.

          (b) Specific Responsibilities. In addition to its general responsibilities set forth in
Section 2.3(a), the JDC shall in particular:

               (i) discuss, prepare and approve for submission to the JSC annual and interim amendments to
the Development Plan and the Development Budget for each Collaboration Product;

               (ii) oversee the implementation of the Development Plan for each Collaboration Product;

 

			
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               (iii) implement the overall strategy for Development and Manufacturing (for Development) of
Collaboration Products, create, implement and review the design and objectives of all Clinical
Trials and Non-Clinical Studies conducted under each Development Plan;

               (iv) decide whether and when to initiate or discontinue, and oversee the conduct of, any
Clinical Trial and any Non-Clinical Study under each Development Plan;

               (v) allocate budgeted resources and determine priorities for each Clinical Trial and
Non-Clinical Study under each Development Plan;

               (vi) establish procedures for each Party to access records, data and Know-How and related
financial information of the other Party with respect to work performed under the Development Plan;
and

               (vii) perform such other functions as may be appropriate to further the purposes of this
Agreement, as directed by the JSC.

          (c) Meetings. Unless the Parties mutually agree in writing to a different frequency, the JDC
shall hold at least [ * ] meetings per year (at least [ * ] of which shall be held in person) on
such dates at such times each year as it elects. The meetings of the JDC shall alternate between
the Parties’ business locations or as otherwise decided by the JDC. Meetings of the JDC shall be
effective only if at least two (2) representatives of each Party are present or participating. Each
Party shall bear the expense of its respective members’ participation in JDC meetings. The
chairperson of the JDC shall be responsible for preparing and issuing minutes of each such meeting
within [ * ] days thereafter. Such minutes shall not be finalized until each Party reviews and
confirms the accuracy of such minutes in writing; provided that any minutes shall be deemed
approved unless a member of the JDC objects to the accuracy of such minutes within [ * ] days after
the circulation of the minutes by the chairperson of the JDC.

          (d) Decision-Making. The JDC shall act by consensus. The representatives from each Party will
have, collectively, one (1) vote on behalf of that Party. If the JDC cannot reach consensus on an
issue that comes before the JDC and over which the JDC has oversight, then such matter shall be
resolved in accordance with Section 2.7.

     2.4 Joint Commercialization Committee.

          (a) Formation and Composition. At such time as determined by the JSC, but in any event not
later than [ * ] following the [ * ] of the [ * ], the Parties shall establish a Joint
Commercialization Committee that shall oversee the Commercialization and Manufacturing (for
Commercialization) of Collaboration Products. Each Party shall initially appoint three (3)
representatives to the JCC, each of whom will be an officer or employee of such Party and will have
knowledge and expertise in the Commercialization and Manufacturing of products similar to the
Collaboration Products and sufficient seniority within the applicable Party to make decisions
arising with the scope of the JCC’s responsibilities. The JCC may change its size from time to time
by mutual consent of its members. Each Party may replace its JCC representatives at any time upon
written notice to the other Party. The JCC may invite non-members (including consultants and
advisors of a Party who are under an obligation of

 

			
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confidentiality consistent with this Agreement) to participate in the discussions and meetings
of the JCC, provided that such participants shall have no voting authority at the JCC. The JCC
shall have a chairperson. Each Party shall have the right, on an alternating Calendar Year basis,
to select from among its JCC representatives a representative to serve as the chairperson of the
JCC during such Calendar Year. Such Party shall have the right during such Calendar Year to
replace the chairperson of the JCC with one of its other JCC representatives. The role of the
chairperson shall be to convene and preside at meetings of the JCC, to prepare agendas (with due
input from the other Party’s representatives), circulate agendas and to ensure the preparation of
meeting minutes, but the chairperson shall have no additional powers or rights beyond those held by
the other JCC representatives.

          (b) Specific Responsibilities. In addition to its general responsibilities set forth in
Section 2.4(a), the JCC shall in particular:

               (i) discuss, prepare and approve for submission to the JSC the Commercialization Plan and the
Commercialization Budget for each Collaboration Product, and any amendment thereto;

               (ii) allocate, in a manner consistent with the Commercialization Plan, primary responsibility
as between the Parties for tasks relating to Commercialization of Collaboration Products on a
Product-by-Product basis;

               (iii) oversee the implementation of the Commercialization Plan for each Collaboration Product;

               (iv) review and discuss the Commercialization activities of each Party with respect to each
Collaboration Product in the Territory;

               (v) review and update sales forecasts for Collaboration Products at least quarterly;

               (vi) review strategies for obtaining, maintaining, defending and enforcing trademark
protection for Collaboration Products;

               (vii) review, discuss, coordinate and approve the Parties’ medical affairs activities (the
responsibility for which may be delegated by the JCC to a subcommittee of the JCC that is comprised
of medical representatives of the Parties); and

               (viii) perform such other functions as may be appropriate to further the purposes of this
Agreement, as directed by the JSC.

          (c) Meetings. Unless the Parties mutually agree in writing to a different frequency, the JCC
shall hold at least [ * ] meetings per year (at least [ * ] of which shall be held in person) on
such dates at such times each year as it elects. The meetings of the JCC shall alternate between
the Parties’ business locations or as otherwise decided by the JCC. Meetings of the JCC shall be
effective only if at least two (2) representatives of each Party are present or participating. Each
Party shall bear the expense of its respective members’ participation in JCC meetings. The
chairperson of the JCC shall be responsible for preparing and issuing minutes of

 

			
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each such meeting within [ * ] thereafter. Such minutes shall not be finalized until each
Party reviews and confirms the accuracy of such minutes in writing; provided that any minutes shall
be deemed approved unless a member of the JCC objects to the accuracy of such minutes within [ * ]
after the circulation of the minutes by the chairperson of the JCC.

          (d) Decision-Making. The JCC shall act by consensus. The representatives from each Party will
have, collectively, one (1) vote on behalf of that Party. If the JCC cannot reach consensus on an
issue that comes before the JCC and over which the JCC has oversight, then such matter shall be
resolved in accordance with Section 2.7.

     2.5 Joint Finance Committee.

          (a) Formation and Purpose. Within [ * ] after the Signing Date, the Parties shall create a
Joint Finance Committee that shall operate under the direction of the JSC to provide services to
and consult with the JDC and the JCC in order to address the financial, budgetary and accounting
issues that arise in connection with the Development Plans and Commercialization Plans.
Additionally, the JFC will lead the economic analyses to help drive decisions regarding the
collaborative activities of the Parties under this Agreement, and lead the reporting and
reconciliation processes outlined in Section 3.7 and Section 9.4. The JFC shall operate by the
procedures set forth in this Section 2.5 and in Section 2.7.

          (b) Membership of the JFC. Each Party shall appoint two (2) representatives to the JFC each
of whom will be an officer or employee of such Party and will have appropriate knowledge and
expertise and sufficient seniority within the applicable Party to make decisions arising within the
scope of the JFC’s responsibilities. Each Party may replace any or all of its JFC representatives
at any time upon prior written notice to the other Party. Such representatives will include
individuals with expertise and responsibilities in the areas of accounting, cost allocation,
budgeting and financial reporting.

          (c) Specific Responsibility of the JFC. In addition to its general responsibilities set forth
in Section 2.5(a), the JFC shall, in particular:

               (i) coordinate with the JSC and other Committees as applicable regarding the preparation and
submission of the Development Budget and the Commercialization Budget to the JSC for review and
approval;

               (ii) develop specific schedules, procedures and methods to implement the financial reporting
and reconciliation provisions of this Agreement, such schedules, procedures and methods to
implement the provisions of Section 3.7 and Section 9.4 shall, unless otherwise determined by the
JSC, be developed within [ * ] after the Signing Date;

               (iii) review and update financial forecasts, which shall be updated at least quarterly for the
remainder of each Calendar Year unless otherwise determined by the JSC, to ensure that Development
Costs and Commercialization Costs incurred or projected to be incurred by each Party are within the
approved Development Budget and Commercialization Budget, respectively;

 

			
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               (iv) coordinate and agree upon the calculations, allocations and reports by each Party of
Development Costs, Commercialization Costs, and Product Profit; and

               (v) perform such other functions as appropriate to further the purposes of this Agreement as
determined by the JSC.

          (d) Meetings of the JFC. The JFC shall meet as frequently as members of the JSC determine is
required (but in no event, less frequently than [ * ] times every Calendar Year), on such dates and
at such times as agreed to by the Parties, with all scheduled in-person meetings to alternate
between a Trubion site and a Facet site as designated by the respective Party prior to such
meeting, or at other locations as determined by the JFC. All meetings shall be held in person or
by audio or videoconference. Additional representatives or consultants, who are under an
obligation of confidentiality consistent with this Agreement, may be invited to attend JFC meetings
from time to time by agreement of the JFC. Each Party shall be responsible for its own expenses
for participating in the JFC. Meetings of the JFC shall be effective only if at least one
representative of each Party is present or participating.

          (e) Decision-Making. The JFC shall act by consensus. The representatives from each Party will
have, collectively, one (1) vote on behalf of that Party. If the JFC cannot reach consensus on an
issue that comes before the JFC and over which the JFC has oversight, then such matter shall be
resolved in accordance with Section 2.7.

     2.6 Joint Patent Committee.

          (a) Formation and Purpose. Within [ * ] after the Signing Date, the Parties shall create a
Joint Patent Committee. The purposes of the JPC shall be to prepare, file and prosecute the
Trubion Product Patent Rights, Facet Product Patent Rights and Joint Patent Rights, as described in
and subject to the terms of Article 10. The JPC shall operate by the procedures set forth in this
Section 2.6 and Section 2.7.

          (b) Membership of the JPC. Each Party shall appoint one (1) representative to the JPC who
will be an officer or employee of such Party and will have appropriate knowledge and expertise and
sufficient seniority within such Party to make decisions arising within the scope of the JPC’s
responsibilities. Each Party may replace its representative at any time upon prior written notice
to the other Party.

          (c) Specific Responsibilities of the JPC. In addition to its general responsibilities set
forth in Section 2.6(a), the JPC shall, in particular be responsible for:

               (i) managing the filing and prosecution of Trubion Product Patent Rights, Facet Product Patent
Rights and Joint Patent Rights as described in and subject to the terms of Article 10;

               (ii) making decisions with respect to certain claims in the Trubion Core Patent Rights as
described in and subject to the terms of Article 10;

               (iii) keeping updated lists of the Trubion Core Patent Rights, Trubion Product Patent Rights,
Facet Product Patent Rights and Facet Patent Rights that would be [ * ] in

 

			
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the event of [ * ] or [ * ] of [ * ] that reflect newly filed patent applications and claim
amendments];

               (iv) reviewing invention disclosures in accordance with the terms of Article 10;

               (v) reviewing licensing and enforcement activities and conflicts involving intellectual
property rights, and making appropriate recommendations to the JSC regarding such matters;

               (vi) providing advice, periodic updates and reports to the JSC regarding intellectual property
matters;

               (vii) using reasonable and customary efforts to monitor and timely analyze freedom to operate
and other intellectual property related issues relating to Collaboration Products;

               (viii) using good faith efforts to keep the Parties informed as to material developments with
respect to the prosecution of, and any adversarial proceedings involving intellectual property
rights, to the extent a Party’s representative on the JPC concludes that such prosecution or
proceeding directly affects a Collaboration Product; and

               (ix) performing such other functions as appropriate to further the purposes of this Agreement
as determined by the JSC.

          (d) Meetings of the JPC. The JPC shall communicate on such dates and at such times as agreed
upon by its members but in no event, less frequently than once every other Calendar Quarter.
Meetings may be held in person or by audio or video conference. The JPC may permit visitors who
are under an obligation of confidentiality consistent with this Agreement to attend meetings of the
JPC. Each Party shall be responsible for its own expenses for participating in the JPC. Meetings
of the JPC shall be effective only if the representative of each Party is present or participating.

          (e) Decisions. Subject to Article 10 below, any approval, determination or other action of
the JPC shall require agreement of both members of the JPC. In the event that a decision cannot be
reached by the JPC, then the matter shall be referred to the respective senior management of the
in-house legal department of each Party. In the event such senior management is unable to resolve
the matter, then the matter will be resolved pursuant to Section 2.7 and Article 15.

     2.7 Resolution of Committee Disputes.

          (a) Within Subcommittees. All decisions within the JDC, the JCC, the JFC, the JPC, and any
other Committee created by the JSC (each, a “Subcommittee”) shall be made by consensus, and if a
dispute arises which cannot be resolved within such Subcommittee, then the representatives of
either Party may cause such matter to be referred to the JSC for resolution as provided in Section
2.7(b).

 

			
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27

 

          (b) Within The JSC. All decisions within the JSC (whether originating there, or referred to
it by a Subcommittee) shall be made by consensus. If a matter is referred by a Subcommittee to the
JSC, the JSC shall use good faith efforts to resolve promptly such matter. If the JSC is unable to
reach consensus on any issue, either Party may elect to submit such issue to the Parties’ Executive
Officers in accordance with Section 2.7(c).

          (c) Referral To Executive Officers. If a Party makes an election under Section 2.7(b) to
refer a matter to the Executive Officers, the JSC shall submit in writing the respective positions
of the Parties to the Executive Officers. Such Executive Officers shall use good faith efforts to
resolve promptly such matter, which good faith efforts shall include at least one [ * ] meeting
between such Executive Officers within [ * ] after the JSC’s submission of such matter to them. If
the Executive Officers are unable to reach consensus on any such matter within [ * ] after the
referral of such matter to the Executive Officers, then the dispute shall be resolved through
arbitration as provided for (a) under Section 15.3(c), with respect to disputes regarding: (i) the
[ * ], (ii) [ * ] and related [ * ] and [ * ] thereto, (iii) [ * ] and related [ * ] and [ * ]
thereto, (iv) whether and when to [ * ] a [ * ] (which may be a [ * ], [ * ] or a [ * ]) for the [
* ] of a [ * ], (v) whether and when to [ * ] a [ * ], (vi) determination of the identity of a [ *
], [ * ], [ * ], and [ * ], and (v) the appointment of a Party to [ * ] the [ * ] or [ * ] thereto;
or (b) under Section 15.3(b), with respect to all other disputes.

     2.8 Discontinuation of Participation on a Committee. Either Party may, in its sole
discretion, terminate its participation on a Committee by providing to the other Party written
notice of its intention to no longer participate in such Committee, which may be made upon [ * ]
written notice at any time during the Co-Development or Co-Commercialization period. In the event a
Party has provided written notice as referred to in this Section 2.8, the Party electing to
terminate its participation shall have no further rights with respect to the decisions otherwise
subject to determination by the Committee and the notified Party shall control any decisions that
were previously the responsibility of the Committee.

3. DEVELOPMENT.

     3.1 Overview. As stated in greater detail in this Article 3, the Parties will Co-Develop each
Collaboration Product in the Field throughout the Territory pursuant to a Development Plan and will
share equally the associated Development Costs.

     3.2 Development Responsibilities. The JSC shall select the lead development party (“Lead
Development Party”) for each Clinical Trial of a Collaboration Product, provided that Trubion shall
be the initial Lead Development Party for all Clinical Trials and Non-Clinical Studies of TRU-016
that are on-going as of the Signing Date. The JSC shall, in allocating Lead Development Party
responsibilities between the Parties: (a) endeavor to take advantage of the respective resources,
capabilities and expertise of Facet and Trubion; (b) endeavor to (i) maintain, to the extent
reasonably practical and appropriate, continuity in functions and commitments of personnel and
physical resources of the Parties, (ii) avoid duplication of efforts by the Parties and (iii)
foster efficient use by the Parties of resources and personnel, consistent with this Agreement and
the Development Plan and Development Budget; and (c) act in the best interests of the
Collaboration. The Lead Development Party shall be responsible for implementing the Development
Plan with respect to the applicable Clinical Trial, provided that

 

			
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28

 

the other Party shall perform all tasks with respect to such Clinical Trial that are allocated
to it pursuant to the Development Plan and may direct and conduct certain additional Development
activities not specifically allocated to either Party pursuant to the Development Plan, if the JDC
agrees upon such allocation. The Lead Development Party shall not have the right to change the
Development Plan or to make changes to the Clinical Trial protocol or the statistical analysis plan
or make changes that affect study design or Clinical Trial strategy (any of the foregoing actions
falling under the authority of the JDC or JSC, as applicable).

     3.3 Development Plan.

          (a) Scope. The Development of Collaboration Products shall be governed by development plans
(each, a “Development Plan”), which, unless otherwise determined by the JSC, shall be Collaboration
Product-specific, indication-specific, multi-year and world-wide (i.e., it shall cover the
Development of each such Collaboration Product for use in the U.S., Japan, each of the Major
European Countries and the EU as a whole, and the remaining countries in the Territory). Each
Development Plan may, as determined by the JSC: (i) provide a planned Development program that is
designed to generate the non-clinical, clinical and regulatory information required for submitting
Drug Approval Applications and to obtain Regulatory Approvals for the relevant indications in the
Territory; (ii) indicate the initial indications that will be pursued with respect to such
Collaboration Product; (iii) address the target product profile for each Collaboration Product for
each indication, as periodically updated; (iv) specify all material Development activities per
indication to be performed for such Collaboration Product for such year, including without
limitation, Clinical Trial protocols, additional preclinical tests (including any and all
carcinogenicity and toxicology studies), Collaboration Product manufacturing plan including
production and supply, and stability studies, enrollment numbers, submission dates and estimated
dates of meetings with FDA for such Collaboration Product; (v) set forth the target timelines for
each indication with respect to such Development activities; (vi) include a forecast of the amount
of Bulk API or finished Collaboration Product needed for such Development activities; and (vii)
assign tasks to each Party with respect to the performance of the Development activities
contemplated by such Development Plan. Each Development Plan shall include a Development Budget.
Each Development Plan and updates thereof shall be prepared by the Party appointed by the JDC, with
input from the other Party’s key clinical development personnel, and submitted pursuant to the
procedures set forth in clause (c) below to the JDC for review and submission to the JSC for
approval.

          (b) Initial Development Plan. A draft of the initial Development Plan, together with
associated initial Development Budget, for TRU-016 is attached hereto as Exhibit B (the
“Initial Development Plan”). The Parties shall make good faith efforts to agree upon the
definitive Initial Development Plan and have it appropriately approved by the JSC within [ * ]
after the Signing Date.

          (c) Updates to the Development Plan. On an annual basis (no later than [ * ] of each Calendar
Year), the Party appointed by the JDC shall prepare amendments to each then-current Development
Plan and each Development Budget. Each such amended Development Plan shall cover the next Calendar
Year and shall contain a corresponding Development Budget. Each such updated and amended
Development Plan shall reflect any changes, re-prioritization of studies within, reallocation of
resources with respect to, or additions

 

			
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29

 

to Development of the applicable Collaboration Product. The amended Development Plan and
Development Budget shall be submitted to the JDC for review and, following such review, to the JSC
for its review and approval. Once approved by the JSC, the amended Development Plan and
Development Budget shall become effective on January 1 of each Calendar Year and shall be in full
force throughout such Calendar Year unless further amended in accordance with this Section 3.3(c).
In any event, any amended or updated Development Plan and Development Budget shall supersede the
previous Development Plan and Development Budget.

     3.4 Standards of Conduct; Diligence.

          (a) Each Party shall perform the Development activities for which it is responsible under the
Development Plan in good scientific manner and in compliance with applicable Laws, including
without limitation applicable GCP, GLP, and GMP. Each Party will keep the other Party fully
informed regarding the progress and results of such Party’s Development activities with respect to
the Collaboration Products through the JDC meetings on a quarterly basis and other than through the
JDC at such other time as necessary under the circumstances.

          (b) Each Party shall use Diligent Efforts to execute and carry out the activities assigned to
it in the Development Plan and shall use Diligent Efforts to execute and carry out such activities
within the Development Budget; provided that if a Party exceeds the portion of such Development
Budget allocated to it with respect to the relevant Calendar Quarter by greater than [ * ] without
the approval of the JSC, any amount in excess of such number shall not be considered Development
Costs and such Party shall be solely responsible for payment of such excess.

          (c) The Parties shall cooperate in good faith to establish appropriate and consistent medical
information support relating to Collaboration Products.

     3.5 Third Parties.

          (a) Contractors. Any Third Party retained by a Party to perform Development activities with
respect to Collaboration Products must be approved in advance in writing by the JSC, such approval
not to be unreasonably withheld or delayed, unless such Third Party and such activities are
pre-existing obligations listed in Schedule 3.7 or are specifically approved in the
Development Plan or Development Budget. Each Party shall remain liable for the performance of its
obligations hereunder which it delegates to such Third Parties.

          (b) Obligations with Respect to Third Party Contracts. Any Third Parties performing
Development activities hereunder shall be subject to confidentiality and non-use obligations at
least as stringent as those set forth in Article 11 with a minimum duration of [ * ] and must
comply with the terms of Section 10.1(c) with respect to any invention or Know-How generated in the
course of performing the Development activities. Unless otherwise determined by the JSC, each
Party shall include provisions in its contracts with Third Parties entered into after the Signing
Date and specifically related to Development or Commercialization of a Collaboration Product that
would permit, in the event that such Collaboration Product becomes a

 

			
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30

 

Royalty Product (i) the assignment of such contract by the Opt-Out Party to the Non-Opt-Out
Party, or (ii) the granting of a sublicense or equivalent right of access to the Non-Opt-Out Party.

          (c) Intellectual Property. Neither Party shall knowingly introduce to any Collaboration
Product any Patent Right or Know-How that is not Controlled by such Party, except with the prior
approval of the JSC.

     3.6 Limitations on Development. After the Signing Date and during the Term, neither Party nor
any of its Affiliates shall, directly or through any Third Party, sponsor, conduct or cause to be
conducted, otherwise assist in, or supply any Collaboration Product for use in connection with, or
otherwise fund, any Clinical Trial of any Collaboration Product outside of the Development Plan,
without the prior written consent of the other Party.

     3.7 Development Costs.

          (a) In general. All Development Costs incurred by either Party shall be borne by the Parties
as follows: Facet shall bear fifty percent (50%) of all Development Costs and Trubion shall bear
fifty percent (50%) of all Development Costs, provided that such costs were incurred pursuant to
the Development Plan, and either do not exceed the portion of the Development Budget allocated to
the applicable Party with respect to the relevant Calendar Quarter by more than [ * ] or are
otherwise approved by the JSC. For clarity, any costs otherwise or previously shared by the
Parties shall not be double counted or otherwise included as a Development Cost even if it meets
such definition.

          (b) FTE Records and Calculations. Each Party shall record its FTE effort for the Development
of each Collaboration Product to the extent that such FTE efforts are included in Development Costs
that are, or may in the future be, shared under this Agreement, and shall report such FTE effort to
the JDC, on a Calendar Quarterly basis, in each case in a manner that allocates such FTE effort to
the extent practicable to each applicable Collaboration Product. Except to the extent provided
herein, each Party shall calculate and maintain records of FTE effort incurred by it in the same
manner as used for other products developed by such Party in accordance with a methodology approved
by the JSC. The JFC shall facilitate any reporting hereunder.

          (c) Other Expenses. Any expenses incurred by a Party for Development activities that do not
fall within the definitions of Development Costs shall be borne solely by such Party unless the JSC
determines otherwise.

          (d) Pre-existing Obligations. Unless otherwise determined by the JSC, any Third Party
obligations of either Party in existence prior to the Signing Date, such as [ * ] or other
obligations described in Section [6.3], other than those listed in Schedule 3.7 will not be
considered Development Costs and will not be subject to expense sharing. For the avoidance of
doubt, any [ * ] to the [ * ] will [ * ] to [ * ] (unless [ * ] by the [ * ]).

          (e) Reports. Each Party shall report to the other Party within [ * ] after the end of each
Calendar Quarter with regard to the Development Costs incurred by it during such quarter. Such
report shall be prepared in accordance with GAAP and shall specify in reasonable detail all
expenses included in such Development Costs during such quarter and shall be

 

			
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31

 

accompanied by invoices, and/or such other appropriate supporting documentation in accordance
with the procedures established by the JSC. Each Party’s report shall include, in addition to the
Development Costs incurred by it during the relevant Calendar Quarter a comparison of the amounts
budgeted in the Development Plan for such activities and the amounts incurred by such Party for
such activities. The Parties shall seek to resolve any questions related to such accounting
statements within [ * ] following receipt by each Party of the other Party’s report hereunder. The
JFC shall facilitate the reporting of Development Costs hereunder and the resolution of any
questions concerning such reports. Each Party shall have the right at reasonable times and upon
reasonable prior notice to audit the other Party’s records as provided in Section 9.9(b) to confirm
the accuracy of the other Party’s costs and reports with respect to Development Costs that are
shared under this Agreement.

          (f) Development Cost Accounts. Each Party shall charge all Development Costs as incurred by
it or its Affiliates on its books and records in accordance with GAAP to enable the tracking of
expenses incurred in connection with each Development Plan. Each Party shall provide the other
Party with an interim quarterly report of monthly estimates for the current Calendar Quarter
charges within [ * ] after the end of the second calendar month in each Calendar Quarter.

          (g) Reconciliation Payment. Within [ * ] after the end of each of the first three Calendar
Quarters and, for the last Calendar Quarter in a Calendar Year, within [ * ] after the end of such
quarter, the Party that has incurred less than its share of such Development Costs shall make a
reconciling payment to the other Party to achieve the appropriate allocation of Development Costs
provided for in Section 3.7(a).

          (h) Records. Each Party shall keep detailed records of the Development Costs it incurs,
including all supporting documentation for such expenses. Each Party shall keep such records for
at least [ * ] after the date that such expense was incurred.

          (i) General Procedures Apply. Any reimbursement payments made pursuant to this Section 3.7
shall be subject to the general payment procedures set forth in Sections 9.6-9.9.

     3.8 Records, Reports and Information. Each Party shall maintain complete, current and
accurate records of all work conducted by it under the Development Plan and all data and other
Know-How resulting from such work. Such records shall fully and properly reflect all work done and
results achieved in the performance of the Development Plan in sufficient detail and in good
scientific manner appropriate for patent and regulatory purposes. Each Party shall provide written
reports to the JDC on its Development and regulatory activities with the Collaboration Product
pursuant to the Development Plan on a quarterly basis at the end of each Calendar Quarter, at a
level of detail reasonably sufficient to enable the other Party to determine the reporting Party’s
compliance with its Diligent Efforts obligations under Section 3.4. Each Party shall have the
right to review any such records maintained by the other Party at reasonable times and upon written
request in accordance with procedures established by the JDC.

 

			
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32

 

4. REGULATORY MATTERS.

     4.1 Transfer of Data and Regulatory Materials. The JDC shall determine the content and manner
for sharing data and Regulatory Materials between the Parties. The lead Party for regulatory
activities with respect to a particular Collaboration Product in a particular country (such Party,
the “Lead Regulatory Party”), as provided in Section 4.3, shall provide the other Party with copies
of the IND and of such other Regulatory Materials Controlled by the Lead Regulatory Party, in each
case with respect to Collaboration Products. Specifically, within [ * ] after the Signing
Date, Trubion shall provide Facet with a copy of all TRU-016 related Regulatory Materials
in the form then existing, generated as of the Signing Date and Controlled by Trubion. The
non-Lead Regulatory Party shall have the right, without any additional consideration, to use any
and all such data and reports supplied by the Lead Regulatory Party under this Section 4.1 in
connection with the Development and/or Commercialization of any Collaboration Products or Royalty
Products in the Field, in the Territory in accordance with the terms of this Agreement, including
the incorporation of such data or reports in any regulatory submissions.

     4.2 Ownership of Regulatory Dossier. The Lead Regulatory Party will own all regulatory
filings for each Collaboration Product in each country where such Party is the Lead Regulatory
Party in order to facilitate such Party’s interactions with Regulatory Authorities in such country
with respect to each such Collaboration Product. Trubion, as initial Lead Regulatory Party for
TRU-016 in the Unites States, will initially own all Regulatory Materials for [ * ] in the [ * ],
including all Regulatory Materials related to [ * ] as of the [ * ]. Promptly upon the JSC’s
decision to change the Lead Regulatory Party or the delivery of a Pursuit Notice or a deemed
Pursuit Notice if the Lead Regulatory Party has exercised or has been deemed to have exercised its
Opt-Out Option pursuant to Article 7, Section 8.5 or Section 14.2(b), the former Lead Regulatory
Party shall transfer and assign to the other Party (and the other Party hereby agrees to receive
from the former Lead Regulatory Party) all of the former Lead Regulatory Party’s right, title and
interest to the applicable regulatory filings.

     4.3 Lead Regulatory Party. The Parties intend that each Development Plan shall set forth the
regulatory strategy approved by the JSC for the applicable Collaboration Product. The JSC shall
select the Lead Regulatory Party for each Collaboration Product, provided that Trubion shall be the
initial Lead Regulatory Party for TRU-016 in the United States and the JSC may change the Lead
Regulatory Party for any Collaboration Product at any time. The Lead Regulatory Party shall be
responsible for the implementation of such strategy in the applicable country. The Lead Regulatory
Party shall comply with applicable Laws and other regulatory obligations related to the submission
and maintenance of any Regulatory Materials for Regulatory Approval of a Collaboration Product, in
the Field, in the applicable country(ies) of the Territory. The Party that is not the Lead
Regulatory Party shall have a participatory role in all material regulatory activities that would
have a potential impact on Collaboration Products in the relevant country, including all
interactions with Regulatory Authorities. All material regulatory decisions (including the content
of any regulatory filing or dossier, pharmacovigilance reports, patient risk management strategies
and plans, Product Labeling and safety) will be made by the JSC and implemented by the Lead
Regulatory Party. Notwithstanding any other provision of this Agreement, the decision to [ * ] any
[ * ] for a [ * ] must be the result of consensus by the JSC or, in the event that the JSC is
unable to reach consensus with respect to such a [ * ] decision

 

			
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and the matter is submitted to the Parties’ Executive Officers pursuant to Section 2.7(b), the
unanimous agreement of the Executive Officers pursuant to Section 2.7(c) to [ * ] such [ * ]. If
the Executive Officers are unable to reach consensus on any such matter within the applicable [ * ]
period, then the JSC will be deemed to have decided not to [ * ] such [ * ]. In no event will a
dispute regarding whether to [ * ] a [ * ] for a [ * ] be resolved through arbitration under
Article 15.

     4.4 Regulatory Filings.

          (a) The Lead Regulatory Party shall prepare, for timely review by the JDC, all IND and BLA
submissions (including any supplements or modifications thereto, but excluding routine submissions
such as study site documentation and adverse event reports (i.e., not relating to serious adverse
events as defined by applicable Law)) to the applicable Regulatory Authority. The other Party
shall have a right to review and comment upon (through its members of the JDC) all draft material
regulatory filings, including without limitation all correspondence to be submitted to the
Regulatory Authority related to Clinical Trial design, the content and subject matter of, and
strategy for, each Drug Approval Application, all proposed Product Labeling (including the final
Regulatory Authority-approved Labeling) and post-Regulatory Approval labeling changes. The Lead
Regulatory Party shall accept and incorporate all reasonable comments provided by the other Party.
Each Party shall promptly provide the other with copies of all written or electronic communications
received by it from, or sent by it to, a Regulatory Authority including IND submissions and
amendments thereof, and all communications (other than routine communications) with respect to
obtaining and maintaining, Regulatory Approvals for a Collaboration Product (it being understood
that routine adverse event filings (i.e., not relating to serious adverse events as defined by
applicable Law) shall not fall within the meaning of maintenance) and copies of all contact reports
produced by such Party. The Lead Regulatory Party shall be the sole Party to initiate contact with
any Regulatory Authorities regarding a Collaboration Product, and shall initiate such contact at
the reasonable request of the other Party.

          (b) Notice of Regulatory Filing Requirements. The Lead Regulatory Party shall provide to the
other Party, within [ * ] of discovery or receipt thereof by the Lead Regulatory Party, notice of
(i) any event with respect to any Collaboration Product that triggers any Regulatory Authority
filing requirement, (ii) any additional requirements which the applicable Regulatory Authority may
impose with respect to obtaining or maintaining Regulatory Approval for a Collaboration Product
(including additional Clinical Trials), and (iii) all Regulatory Authority inquiries with respect
to a Collaboration Product that require a response or for a which a response may be advisable. The
JDC shall discuss in good faith and on a timely basis determine the most effective and expeditious
means of responding to such Regulatory Authority filing requirements, additional requirements or
inquiries.

     4.5 Regulatory Meetings. The Lead Regulatory Party shall provide the other Party with notice
of all meetings, conferences, and discussions (including Regulatory Authority advisory committee
meetings and any other meeting of experts convened by the Regulatory Authority concerning any topic
relevant to a Collaboration Product, as well as Collaboration Product labeling and post-Regulatory
Approval Collaboration Product labeling discussions with any Regulatory Authority) scheduled by the
Regulatory Authority concerning any pending Drug Approval Application or any material regulatory
matters relating to a Collaboration Product

 

			
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within [ * ] after the Lead Regulatory Party receives notice of the scheduling of such
meeting, conference, or discussion (or within such shorter period as may be necessary in order to
give the other Party a reasonable opportunity to participate in such meetings, conferences and
discussions). The other Party shall be entitled to be present at, and to participate in, all such
meetings, conferences or discussions. Facet’s and Trubion’s respective members of the JDC shall
use reasonable efforts to agree in advance on the scheduling of such meetings and on the objectives
to be accomplished at such meetings, conferences, and discussions and the agenda for the meetings,
conferences, and discussions with the Regulatory Authority. The Lead Regulatory Party shall
reasonably attempt to include the other Party in any unscheduled, ad-hoc meetings, conferences and
discussions with the Regulatory Authority concerning any pending IND, Drug Approval Application or
any material regulatory matters relating to a Collaboration Product, and will promptly copy such
other Party on a contact report.

     4.6 Regulatory Data. In accordance with procedures established by the JDC, each Party shall
provide to the other Party on a timely basis access to or copies of all material pre-clinical and
clinical data generated or compiled pursuant to the Development Plan with respect to Regulatory
Materials maintained by such Party (via electronic copies of such data in a form that may be
analyzed and manipulated by the other Party).

     4.7 Common Database. If deemed appropriate by the JDC, the Parties will establish a common
database to be controlled, maintained and administered by the Party designated by the JDC for the
receipt, investigation, recordation, communication, and exchange (as between the Parties) of data
arising from Clinical Trials for Collaboration Products. The Parties shall agree upon guidelines
and procedures for such common database that shall be in accordance with, and enable the Parties to
fulfill their reporting obligations under applicable Law. Furthermore, such guidelines and
procedures shall be consistent with relevant International Council for Harmonisation (“ICH”)
guidelines. The Parties’ costs incurred in connection with receiving, investigating, recording,
reviewing, communicating, and exchanging such data shall be included as an element of Development
Costs or as Commercialization Costs, as applicable, calculated on a FTE cost (calculated at the FTE
Rate) and direct out-of-pocket cost basis.

     4.8 Rights of Reference. Each Party shall have the right to cross reference, file or
incorporate by reference any regulatory filing or drug master file (as defined in 21 C.F.R.
314.420, or as amended from time to time, or the corresponding foreign equivalent) (and any data
contained therein) for any Collaboration Product, or any component thereof, made in any country in
the Territory (including all Regulatory Approvals) in order to support regulatory filings that such
Party is permitted to make under this Agreement for any Collaboration Product or Royalty Product
and to enable either Party to fulfill its obligations under this Agreement to Develop, Manufacture
or Commercialize in the Territory any such Collaboration Product or Royalty Product. Each Party
shall support the other, as may be reasonably necessary, in obtaining Regulatory Approvals for each
Collaboration Product and Royalty Product, including providing necessary documents, or other
materials required by applicable Law to obtain Regulatory Approvals, in each case in accordance
with the terms and conditions of this Agreement.

     4.9 Costs and Expenses. Unless otherwise agreed by the JSC and subject to Section 3.4(b), any
costs required for the Parties to prepare, submit and maintain all Regulatory Materials

 

			
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in the Territory shall be treated as Development Costs to the extent such costs are incurred
in accordance with the Development Plan and do not exceed the portion of the Development Budget
allocated to such regulatory activities to the applicable Party with respect to the relevant
Calendar Quarter by more than [ * ] or are otherwise approved by the JSC.

     4.10 Consultation, Reporting and Review.

          (a) Each Lead Regulatory Party shall keep the other Party reasonably and regularly informed of
the status of the preparation of all Regulatory Materials, Regulatory Authority review of
Regulatory Materials, and Regulatory Approvals made by it for Collaboration Products in the Field.

          (b) Each Lead Regulatory Party shall provide the other Party, in a timely manner, with copies
of all Regulatory Approvals it receives for Collaboration Products in the Field.

          (c) Each Party shall provide the other Party, in a timely manner, with copies of, and all
information received by it pertaining to, notices, questions, actions and requests from or by
Regulatory Authorities with respect to Collaboration Products, in the Field, or the testing,
manufacture, distribution or facilities in relation thereto, including without limitation any
notices of non-compliance with Laws in connection with Collaboration Products in the Field (e.g.,
warning letters or other notices of alleged non-compliance), audit notices, notices of initiation
by Regulatory Authorities of investigations, inspections, detentions, seizures or injunctions
concerning Collaboration Products (or their manufacture, distribution, or facilities connected
thereto), notice of violation letters (i.e., an untitled letter), warning letters, service of
process or other inquiries.

     4.11 Regulatory Inspection or Audit. If a Regulatory Authority in the Territory desires to
conduct an inspection or audit with regard to a Collaboration Product of a Party’s facility or a
facility under contract with a Party, or with regard to a Royalty Product of the Opt-Out Party’s
facility or a facility under contact with the Opt-Out Party when the Opt-Out Party continues to
supply the Royalty Product to the Non-Opt-Out Party pursuant to Section 7.5(b)( vi), such Party
shall promptly notify the other Party. In such case, the audited Party shall permit and cooperate
with such inspection or audit, and shall cause the contract facility to permit and cooperate with
such Regulatory Authority during such inspection or audit. The other Party shall have the right to
have a representative observe such inspection or audit and shall, if requested by the audited
Party, assist the audited Party in preparing for, facilitating or enabling such inspection or
audit. Following receipt of the inspection or audit observations of such Regulatory Authority (a
copy of which the audited Party shall immediately provide to the other Party), the audited Party
shall prepare a draft response to any such observations, in consultation with the other Party, and
the Party that holds the Regulatory Materials in the applicable country or territory shall prepare
and file the final response with such Regulatory Authority. If the Regulatory Authority is
conducting an inspection or audit with regard to a Party’s contract facility, such Party shall
(subject to the terms of the applicable contract with a Third Party manufacturer) cause its
contract facility to prepare, submit to both Parties for input, and file the final response
incorporating such input with such Regulatory Authority, and copy both Parties on such submission.

 

			
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     4.12 Pharmacovigilance Agreement. Subject to the terms of this Agreement, and at a date to be
determined by the JDC, Facet and Trubion shall define and finalize the actions the Parties shall
employ to protect patients and promote their well-being in a written agreement (hereinafter
referred to as the “Pharmacovigilance Agreement”). These responsibilities shall include mutually
acceptable guidelines and procedures for the receipt, investigation, recordation, communication,
and exchange (as between the Parties) of adverse event reports, pregnancy reports, and any other
information concerning the safety of any Collaboration Product. Such guidelines and procedures
shall be in accordance with, and enable the Parties to fulfill, local and national regulatory
reporting obligations to Governmental Authorities. Furthermore, such agreed procedures shall be
consistent with relevant ICH guidelines, except where said guidelines may conflict with existing
local regulatory safety reporting requirements, in which case local reporting requirements shall
prevail. The Pharmacovigilance Agreement will provide for a worldwide safety database to be
maintained by the Party appointed by the JDC. Each Party hereby agrees to comply with its
respective obligations under such Pharmacovigilance Agreement (as the Parties may agree to modify
it from time to time) and to cause its Affiliates and permitted sublicensees to comply with such
obligations.

5. COMMERCIALIZATION.

     5.1 Overview. The Parties agree to collaborate with respect to the Commercialization of
Collaboration Products, in the Field, in the Territory as provided in this Article 5. The JSC shall
choose the Party, on a country-by-country and Collaboration Product-by-Collaboration Product basis,
with the greatest applicable Commercial capability with respect to a particular Collaboration
Product in a particular country as the lead commercialization party (“Lead Commercialization
Party”) for such Collaboration Product in such country to coordinate the implementation of the
Commercialization Plan in accordance with the allocation of responsibilities set forth therein.

     5.2 Commercialization Plan.

          (a) Scope. The Commercialization of Collaboration Products shall be conducted pursuant to
commercialization plans (each, a “Commercialization Plan”), which, unless otherwise determined by
the JSC, shall be Collaboration Product-specific, multi-year, world-wide, and shall set forth the
anticipated Commercialization activities (including market studies, launch plans, Detailing and
Promotion) and timelines, shall allocate responsibility for carrying out such activities between
Facet and Trubion, and shall include the Commercialization Budget for such activities. Each
Commercialization Plan may, as determined by the JSC, include a lifecycle plan and the plan, with
respect to each country, for: (i) Detailing and Promotion activities for the applicable
Collaboration Product for the next [ * ] (as to the initial Commercialization Plan, the [ * ]
following launch) and timelines for performing such activities, (ii) target audience, (iii)
anticipated expenses, (iv) assumptions regarding product profile, (v) sales force size, and (vi)
Promotional efforts. Each Commercialization Plan shall include a Commercialization Budget. Each
Commercialization Plan and updates thereof shall be prepared by the Lead Commercialization Party in
the United States for such Collaboration Product, with review by and input from the other Party’s
key personnel for Commercialization and Manufacturing activities, and submitted pursuant to the
procedures set forth in clauses (b) and (c) below to the JCC for review and submission to the JSC
for approval.

 

			
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          (b) Initial Commercialization Plan. Promptly following the JSC’s request for a
Commercialization Plan for a particular Collaboration Product and at least [ * ] prior to the
then-current date of expected Regulatory Approval for such Collaboration Product in the Field, the
Lead Commercialization Party in the United States for such Collaboration Product, with strategic
guidance from the JSC, shall prepare the initial Commercialization Plan for such Collaboration
Product and submit such plan to the JCC for review and, following such review, to the JSC for its
review and approval. The Parties agree and acknowledge that any such Commercialization Plan will
reasonably allocate all Commercialization activities between the Parties, giving equal
consideration to each Party’s abilities when making such allocation.

          (c) Updates to the Commercialization Plan. On an annual basis (no later than [ * ] of each
Calendar Year), the Lead Commercialization Party in the United States for such Collaboration
Product shall prepare amendments to the then-current Commercialization Plan and the
Commercialization Budget. Such amended Commercialization Plan shall cover the next Calendar Year
and shall contain a corresponding Commercialization Budget. Such updated and amended
Commercialization Plan shall reflect any changes, re-prioritization of activities within,
reallocation of resources with respect to, or additions to Commercialization of the applicable
Collaboration Product. The amended Commercialization Plan and Commercialization Budget shall be
submitted to the JCC for review and, following such recommendation, to the JSC for its review and
approval. Once approved by the JSC, the amended Commercialization Plan and Commercialization
Budget shall become effective on January 1 of each Calendar Year and shall be in full force
throughout such Calendar Year unless further amended in accordance with this Section 5.2(c). In
any event, any amended or updated Commercialization Plan and Commercialization Budget shall
supersede the previous Commercialization Plan and Commercialization Budget.

     5.3 Commercialization Reports. Each Party will keep the JCC fully informed regarding the
progress and results of its Commercialization activities with respect to Collaboration Products
under this Agreement.

     5.4 Standards of Conduct.

          (a) Each Party shall perform, or shall ensure that its Affiliates and permitted sublicensees
and Third Party contractors perform, all Commercialization activities assigned to it in a good
scientific and ethical business manner and in compliance with applicable Laws.

          (b) Each Party shall use Diligent Efforts to execute and carry out the activities assigned to
it in the Commercialization Plan and each Party shall use Diligent Efforts to execute and carry out
such activities within the Commercialization Budget; provided that if a Party exceeds the portion
of the Commercialization Budget allocated to it with respect to the relevant Calendar Quarter by
greater than [ * ] without the approval of the JSC, any amount in excess of such number shall not
be considered Commercialization Costs hereunder and such Party shall be solely responsible for
payment of such excess.

     5.5 Sales Force Training. The Lead Commercialization Party shall develop and conduct training
programs for the sales representatives of one or both Parties’ sales representatives (depending on
whether one or both Parties will be Detailing the Collaboration

 

			
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Product), specifically relating to the Collaboration Products to be Commercialized. Each
Party agrees to utilize such training programs on an ongoing basis to assure a consistent, focused
promotional strategy.

     5.6 Product Labeling and Promotional Materials. The JCC shall determine which Party shall be
responsible for designing and supplying the Product Labeling and Promotional Materials for each
Collaboration Product in the Territory. Such responsible Party shall provide samples of such
labeling and materials to the JCC for review and consultation prior to finalizing such materials
for use by the Parties’ sales representatives. The Parties shall describe in the applicable
Commercialization Plan how and the manner in which the Parties shall be presented and described to
the medical community in any Promotional Materials and the placement of the names and logos of the
Parties therein, in each case as permitted by applicable Law and in accordance with the labeling
for the Collaboration Product approved by the applicable Regulatory Authority.

     5.7 Branding. Each Collaboration Product Commercialized under this Agreement shall be
Commercialized under and in connection with the Marks selected in accordance with Section 10.7. To
the extent that a Party is granted rights under this Agreement to Commercialize a Collaboration
Product, it shall Commercialize such Collaboration Product solely under and in connection with the
Marks selected and approved pursuant to the terms of Section 10.7 (except for Marks that include,
in whole or part, any corporate name or logo of such Party, which Marks do not require such
approval).

     5.8 Pricing. The JSC will determine the selling price (including volume discounts (including
those available, without limitation, to managed care providers, indemnity plans, unions, self
insured entities, and government payer, insurance or contracting programs such as Medicare,
Medicaid, or the United States Dept. of Veterans Affairs), rebates, and similar matters, credit
terms, and return policies) for all Collaboration Products Commercialized hereunder. The Lead
Commercialization Party for a particular Collaboration Product in a particular country shall have
the right and responsibility for proposing to the JCC for review and submission to the JSC for
approval the terms and conditions (and any updates and revisions thereof) with respect to the sale
of such Collaboration Product in such country, including any terms and conditions relating to or
affecting the price at which the Collaboration Product shall be sold, discounts, any discount
attributable to payments on receivables, distribution of the Collaboration Product, and credits,
price adjustments, or other discounts and allowances to be granted or refused.

     5.9 Booking of Sales. The Lead Commercialization Party for a particular Collaboration Product
in a particular country will book sales in accordance with GAAP including handling inventory,
receivables, managing relationships with the trade, returns, reimbursements, and charge-backs,
trade-customer complaints and inquiries with respect to such Collaboration Product in such country.
For clarity, each Party’s expenses in connection with the activities described in this Section 5.9
will be included as Sales and Marketing Costs or Distribution Costs, as appropriate.

     5.10 Product Recalls. Decisions with respect to recalls, withdrawals or other corrective
actions (“Recall”) with respect to any Collaboration Product related to manufacturing or product
quality issues shall be handled in accordance with the Commercial Supply

 

			
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Agreement. Decisions with respect to any other Recall related to any Collaboration Product
shall be made only upon mutual agreement of the Parties; provided, however, that nothing herein
shall [ * ] Party [ * ] or [ * ] any [ * ] (i) [ * ] by a [ * ] or [ * ] or (ii) which in [ * ] is,
or such Party [ * ] will [ * ], a [ * ] or [ * ] (under [ * ], or [ * ] of the [ * ]). The Parties
shall cooperate with respect to any actions taken or public statements made in connection with any
such Recall. Except as otherwise provided in this Section 5.10, the Parties will share all costs of
a Recall with respect to any Collaboration Product as Sales and Marketing Costs. Notwithstanding
the foregoing, a Party shall bear any and all costs of a Recall, market withdrawal or other
corrective action with respect to a Collaboration Product in the Territory, including the
Manufacturing Costs for the Collaboration Product in question, to the extent the Recall is
attributable to the fault of such Party and results from (a) a grossly negligent or reckless act or
omission or intentional misconduct of such Party (or its Affiliate, agent or permitted
sublicensee), (b) in the case such Party is the Lead Manufacturing Party, the failure of the Lead
Manufacturing Party or its Affiliate, agent or sublicensee to perform its responsibilities and
Manufacture the Collaboration Product in compliance with the specifications (as set forth in the
Commercial Supply Agreement), or with applicable Laws, including applicable Good Manufacturing
Practices, (c) any defect or condition introduced by a Party, its Affiliates or permitted
sublicensees following delivery of the Collaboration Product from the Lead Manufacturing Party or
its contract manufacturer, into a Collaboration Product or its packaging or labeling, or (d) a
breach of any Laws or the terms of this Agreement by such Party.

     5.11 Co-Promotion Agreement. In the event that both Parties have their own sales forces with
appropriate expertise or that the Parties otherwise agree to share promotional responsibilities
with respect to one or more Collaboration Products in one or more countries, the Parties shall
negotiate in good faith and enter into a co-promotion agreement for such Collaboration Product in
such countries to implement the promotional activities contemplated in the Commercialization Plan
for such Collaboration Product in such country.

     5.12 Limitations on Commercialization. After the Signing Date and during the Term, neither
Party nor any of its Affiliates shall, directly or through any Third Party, Commercialize any
Collaboration Product outside of the Commercialization Plan, without the prior written consent of
the other Party.

6. MANUFACTURING.

     6.1 Roles of the Parties. The JSC shall select the lead manufacturing Party (“Lead
Manufacturing Party”) for each Collaboration Product and the Lead Manufacturing Party shall be
responsible for the supply of the Parties’ entire requirements of such Collaboration Product in
accordance with the terms set forth below. Trubion shall be the initial Lead Manufacturing Party
for TRU-016.

          (a) Facet acknowledges that Trubion uses Third Party manufacturers to Manufacture TRU-016, and
Trubion confirms that it shall be solely responsible for the performance of such Third Party
manufacturers until such time as the Parties determine to engage an alternate or additional source
of supply, or the Parties agree to amend such agreements in accordance with Section 6.4.

 

			
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          (b) Trubion shall promptly notify existing Third Party manufacturers of execution of this
Agreement, and, if Trubion proposes to materially amend, or to extend the term of, any existing
Product manufacturing agreement with a Third Party, use Diligent Efforts to include Facet as a
party to such agreement or to provide Facet with third party beneficiary rights with respect to
such agreement and to allow for assignment of such agreement, or, if such agreement also applies to
products that are not Products, assignment of all rights and obligations to the extent related to
such Product, in each case from Trubion to Facet without consent from such Third Party
manufacturer.

     6.2 Pre-Clinical and Clinical Supply. The Lead Manufacturing Party with respect to a
particular Collaboration Product shall, by itself or through its Third Party contract
manufacturers, timely supply all quantities of such Collaboration Product agreed upon by the JDC as
required by the Parties to carry out all Development activities (pre-clinical and clinical) for
such Collaboration Product pursuant to the Development Plan. Such quantities of Collaboration
Product, and the schedule for such supply, shall be confirmed and if necessary updated by the JDC
in a manner consistent with the Development Plan. Such supply shall be considered a Development
Cost and charged on an accrual basis; provided that any [ * ] of [ * ] of the [ * ] shall [ * ] as
[ * ]. [ * ] in [ * ] of the [ * ] shall [ * ] as [ * ] except when it is [ * ] to [ * ] or [ * ]
after [ * ] by the [ * ]. The JSC shall, in allocating Lead Manufacturing Party responsibilities
between the Parties: (a) endeavor to take advantage of the respective resources, capabilities and
expertise of Facet and Trubion; (b) endeavor to (i) maintain, to the extent reasonably practical
and appropriate, continuity in functions and commitments of personnel and physical resources of the
Parties, (ii) avoid duplication of efforts by the Parties and (iii) foster efficient use by the
Parties of resources and personnel, consistent with this Agreement and the applicable then-current
Development Plan and Development Budget; and (c) act in the best interests of the Collaboration.
The Lead Manufacturing Party shall ensure that all finished Collaboration Product supplied pursuant
to the Development Plan shall, when delivered, have been manufactured, handled and stored in
compliance with all agreed-upon specifications, then-current GMP requirements and applicable Laws,
including without limitation prohibitions on misbranding and adulteration. The Lead Manufacturing
Party shall reasonably determine the process for quantity orders, timing for delivery and shipping
terms to permit the Parties to fulfill their obligations under the Development Plan.

     6.3 Pre-existing Obligations with Third-Party Manufacturers. Unless otherwise determined by
the JSC, any Third Party obligations in existence prior to the Signing Date for manufacturing of
TRU-016, such as manufacturing capacity reservation, other than those listed in Schedule
3.7 will not be considered Manufacturing Costs and will not be subject to expense sharing. For
the avoidance of doubt, any [ * ] to the [ * ] will [ * ] to [ * ] (unless [ * ] by the [ * ]).

     6.4 Alternative Supply Arrangements. Unless otherwise determined by the JSC, in the event
that: (a) the Lead Manufacturing Party proposes to enter into one or more new manufacturing
agreements, (b) the Lead Manufacturing Party proposes to materially amend, to renegotiate or to
renew its then existing Third Party manufacturing agreements, or (c) the Lead Manufacturing Party
notifies the JSC that capacity or quality under the existing Third Party manufacturing agreements
will not be sufficient to meet the needs of the Parties under the Development Plan, the JSC shall
determinate the appropriate course of action, including a

 

			
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determination of whether a second source of supply is appropriate. In any event, the Lead
Manufacturing Party shall notify the other Party and the JSC prior to entry into any such new,
amended or renewed Third Party manufacturing agreement, and the JSC shall review and approve the
proposed terms of such new, amended or renewed agreement; provided that such agreement may include,
as agreed upon by the JSC (i) attempting to order in full lot or production run batches and
otherwise reducing the Manufacturing Cost of Collaboration Product, (ii) providing for sufficient
capacity and timely supply to satisfy the requirements of the then-current Development Plan, (iii)
having Facet and Trubion as parties (and in any event third party beneficiaries) with respect to
the rights and obligations related to Collaboration Products pursuant to such Third Party
agreement, (iv) ensuring that in the event of the exercise or deemed exercise of an Opt-Out Option
by a Party, the remaining Party shall be the sole obligor pursuant to such Third Party Agreement,
(v) providing that the Parties shall have joint rights and obligations under the agreement with
respect to Collaboration Product, but that one Party shall be designated as the “principal party”
under such agreement, (v) providing both Parties with the right to audit and inspect such Third
Party’s facilities on at least [ * ], which efforts shall be coordinated between the Parties in the
event both Parties desire to conduct such audit and inspection, and (vi) providing for complete
sharing of any and all information under and the terms and conditions of such agreement between the
Parties. The Lead Manufacturing Party shall be responsible for negotiating the terms of such
agreement, with the other Party having consultation and review rights on the terms of such Third
Party agreement.

     6.5 Commercial Supply Agreement. Unless a Party has already exercised its Opt-Out Option or
is deemed to have exercised its Opt-Out Option under Section 14.2(b), at least [ * ] prior to the
anticipated commercial launch of a Collaboration Product, the Parties shall negotiate in good faith
and enter into a manufacturing and supply agreement (the “Commercial Supply Agreement”) governing
the commercial supply of such Collaboration Product. Such Commercial Supply Agreement shall contain
customary terms governing such manufacturing and supply relationships, but shall in any event
provide as follows:

          (a) Collaboration Product (i) shall meet the agreed specification, then-current GMP and be
manufactured in accordance with applicable Laws including prohibitions on adulteration and
misbranding, (ii) shall be supplied by or on behalf of the Lead Manufacturing Party in a timely
manner consistent with established and agreed manufacturing and delivery schedules; and (iii) shall
be supplied at a cost equal to the Manufacturing Cost of such Collaboration Product.

          (b) Upon a material and uncured breach by the Lead Manufacturing Party of its supply
obligations, the other Party shall have the right to obtain the transfer and the Lead Manufacturing
Party shall have the obligation to (i) effect such transfer [ * ] to the other Party, without undue
delay, of any and all manufacturing technology reasonably necessary for the Manufacture of the
applicable Collaboration Product included in the Trubion Know-How or included in the Facet Know-How
that (x) has been applied to the Manufacture of the applicable Collaboration Product prior to Facet
ceasing to be the Lead Manufacturing Party, or (y) is [ * ] in the [ * ] applied to the Manufacture
of the applicable Collaboration Product [ * ], as applicable, not already in the other Party’s
possession in the form and format in which such Know-How is maintained by the Lead Manufacturing
Party or its Third Party manufacturers in the ordinary course of business, and to (ii) at the other
Party’s request, use Diligent Efforts to obtain an

 

			
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assignment of any Third Party manufacturing agreement in each case as reasonably necessary to
enable the other Party to Manufacture or have Manufactured Collaboration Product in accordance with
the terms of this Agreement, provided, however, that the Lead Manufacturing Party shall be required
to assign any such agreement solely to the extent assignment is permitted by such agreement,
provided that the Lead Manufacturing Party uses Diligent Efforts to obtain any consent necessary
for such assignment, and the Lead Manufacturing Party is not required to pay any consideration or
commence litigation in order to effect an assignment of any such agreement to the other Party. In
the event the Lead Manufacturing Party exercises or is deemed to have exercised its Opt-Out Option
pursuant to Article 7, Section 8.5 or Section 14.2(b), then Sections 7.5(b)(iii) and 7.5(b)(x)
shall apply.

          (c) The Manufacturing Costs of commercial supplies of Collaboration Product as well as the
duty, freight, postage, shipping, transportation, insurance, warehousing and handling charges
actually allowed or paid with regard to such Collaboration Product shall be included in the
calculation of cost of goods sold as part of Commercialization Costs.

     6.6 Facility Audits. The JDC shall propose and submit to the JSC for approval a schedule for
periodic audit and inspection of the facilities of any Third Party contract manufacturer on at
least an annual basis subject to the terms of any applicable existing contract with a Third Party
contract manufacturer. Pursuant to the schedule approved by the JSC, or upon request of the JDC,
the Lead Manufacturing Party shall conduct an inspection or audit of the facilities of such Third
Party contract manufacturers. The Lead Manufacturing Party shall provide not less than [ * ]
notice to the other Party of any planned inspection and such other Party shall be permitted to
participate in any audit, provided that, if the consent of the Third Party contract manufacturer is
required under the applicable contract to allow such other Party to participate in such audit, the
Lead Manufacturing Party shall use Diligent Efforts to obtain such consent. Any inspection or audit
requested by the JDC (other than pursuant to the schedule approved by the JSC) shall be conducted
no more frequently than [ * ] at a given facility, and shall occur as promptly as possible
following written notice by the JDC of its desire for such inspection or audit, but in no event
shall such inspection commence later than [ * ] thereafter (unless such audit is triggered by a
material safety or GMP non-conformance issue, in which case the audit may be conducted as
frequently as necessary and the maximum notice period shall be [ * ] if permitted under the
applicable contract). Costs associated with auditing shall be Development Costs or
Commercialization Costs as applicable.

     6.7 Quality Agreement. The Parties shall negotiate in good faith and enter into a quality
agreement governing the quality control, quality assurance and validation of the commercial and
clinical supply of Bulk API and Product.

7. OPT-OUT.

     7.1 General. Each Party shall have the right to opt-out of all of its rights and obligations
to Co-Develop and Co-Commercialize any Collaboration Product pursuant to Sections 7.2 and 7.3 below
(an “Opt-Out Option”). In addition, each Party may also exercise its Opt-Out Option pursuant to
Section 8.5, and may be deemed to have exercised its Opt-Out Option pursuant to Section 14.2(b).
The Opt-Out Party may exercise its Opt-Out Option pursuant

 

			
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omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

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to Sections 7.2, 7.3 or 8.5 by providing a written notice (an “Opt-Out Notice”) to the
Non-Opt-Out Party.

     7.2 Opt-Out Option. Each Party may, on a Product-by-Product basis, exercise its Opt-Out
Option with respect to any Collaboration Product by providing an Opt-Out Notice to the other Party
during one of the following periods: (a) the period beginning with the [ * ] for such Collaboration
Product and ending [ * ] later; (b) the period beginning with the [ * ] for such Collaboration
Product and ending [ * ] later. In addition, Trubion may, on a Product-by-Product basis, exercise
its Opt-Out Option with respect to any Collaboration Product by providing an Opt-Out Notice to
Facet at any time after [ * ] after the [ * ] and prior to the [ * ] for such Collaboration
Product. Each such Opt-Out Notice shall identify the Collaboration Product for which the Opt-Out
Party is exercising the Opt-Out Option (the “Opt-Out Product”). If a Party is deemed to have
exercised its Opt-Out Option pursuant to Section 14.2(b), all Collaboration Products shall be
deemed Opt-Out Products and Royalty Products.

     7.3 Opt-Out Option Following Change of Control. If either Party (the “Acquired Party”)
experiences a Change of Control, it shall inform the other Party within [ * ] following the
effectiveness of such Change of Control and it shall use Diligent Efforts to arrange for the
acquiring entity to discuss with the other Party the acquiring entity’s (a) intentions with respect
to the Development and Commercialization of the Collaboration Products and (b) contemplated
proposals for amending the Development Plan and, if applicable, Commercialization Plan for each
Collaboration Product, and the other Party may exercise its Opt-Out Option with respect to all
Collaboration Products by providing an Opt-Out Notice to the Acquired Party or its successor in
interest within [ * ] of such Change of Control and all Collaboration Products shall become Opt-Out
Products on the Opt-Out Effective Date.

     7.4 Opt-Out Effective Date. An Opt-Out Option shall become effective [ * ] after the
Non-Opt-Out Party’s receipt of such Opt-Out Notice (the “Opt-Out Effective Date”). Notwithstanding
the foregoing, if a Party, after uncured material breach, is deemed to have exercised its Opt-Out
Option pursuant to Section 14.2(b), then both the date of the Opt-Out Notice and the Opt-Out
Effective Date for such Opt-Out Option shall be deemed to be the date on which the other Party
provides the notice under Section 14.2(b) to continue this Agreement and all Collaboration Products
shall become Royalty Products on such date.

     7.5 Consequences of Opt-Out.

          (a) The Opt-Out Party’s obligations and rights to Co-Develop and Co-Commercialize a particular
Opt-Out Product shall terminate upon the applicable Opt-Out Effective Date, and the Opt-Out Party
shall have no liability for Development Costs or Commercialization Costs incurred by the
Non-Opt-Out Party in respect of the Opt-Out Product(s) following the Opt-Out Effective Date,
provided, however, that the Opt-Out Party shall remain liable for its share of (i) [ * ] for all [
* ] for the [ * ] that were [ * ] to the [ * ] to the extent that such [ * ] for such [ * ] by [ *
] the [ * ] therefor in the [ * ] that was [ * ] on the [ * ], (ii) all other [ * ] and all [ * ]
with respect to the [ * ] the [ * ] in accordance and consistent with the [ * ] or [ * ], as
applicable and [ * ], and (iii) all [ * ], including [ * ] and [ * ], [ * ] in connection with [ *
] and [ * ] under Section [ * ], to the extent related to [ * ], [ * ], [ * ] or [ * ] of the
applicable [ * ] within the Field anywhere in the Territory [ * ] the [ * ] and [ * ] the [ * ]

 

			
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for such activities for which [ * ] is [ * ] under Section [ * ] or Section [ * ] and to the
extent provided in Section [ * ].

          (b) The Non-Opt-Out Party may, in its sole discretion, elect to continue the Development and
Commercialization of the Opt-Out Product by notice (the “Pursuit Notice”) to the Opt-Out Party. If
the [ * ] does not [ * ] a [ * ] with respect to [ * ] within [ * ] following the [ * ] of the [ *
], the [ * ] shall not [ * ] to [ * ] the [ * ] and [ * ] of the [ * ] and the [ * ] to the [ * ]
shall [ * ] with respect to that [ * ]. Notwithstanding the foregoing, if a Party is deemed to have
exercised its Opt-Out Option pursuant to Section 14.2(b), then the Non-Opt-Out Party shall be
deemed to have provided a Pursuit Notice to the Opt-Out-Party by providing a written notice of
continuation of the Agreement pursuant to Section 14.2(b). If the Non-Opt-Out Party delivers a
Pursuit Notice with respect to an Opt-Out Product [ * ] such [ * ] or is deemed to have delivered
such Pursuit Notice, such Opt-Out Product shall become a Royalty Product, and:

               (i) the Non-Opt-Out Party shall be solely responsible, at its sole cost and expense (except
for those costs for which the Opt-Out Party remains responsible pursuant to Section 7.5(a)) for the
Development of such Royalty Product, the preparation and filing of Regulatory Materials for such
Royalty Product, the receipt of Regulatory Approval for such Royalty Product, and the
Commercialization of such Royalty Product, in each case in the Field in the Territory. The
Non-Opt-Out Party shall use Diligent Efforts to Develop and obtain Regulatory Approval for Royalty
Products and to Commercialize such Royalty Products in the Field in the Major Market Countries;

               (ii) the Non-Opt-Out Party will inform the Opt-Out Party of the status of the Non-Opt-Out
Party’s Development and Commercialization of Royalty Products through [ * ] progress reports
submitted in writing to the Opt-Out Party, provided that if the Opt-Out Party remains responsible
for the costs of any [ * ] pursuant to Section 7.5(a), the Non-Opt-Out Party shall additionally
provide [ * ] reports and invoices with respect to such [ * ];

               (iii) the Opt-Out Party shall provide reasonable consultation and assistance during a period
of [ * ] following the Opt-Out Party’s receipt of the Pursuit Notice or written notice of
continuation of the Agreement pursuant to Section 14.2(b), (“Transition Assistance”) for the
purpose of transferring or transitioning to the Non-Opt-Out Party, (i) all Facet Applied Know-How
or Trubion Know-How, as applicable, which is reasonably necessary for the continued Development,
Manufacture or Commercialization of the Royalty Product not already in the Non-Opt-Out Party’s
possession in the form and format in which such Know-How is maintained by the Opt-Out Party or its
Affiliate or subcontractor in the ordinary course of business, and (ii) at the Non-Opt-Out Party’s
request, the Opt-Out Party shall use Diligent Efforts to assign to the Non-Opt-Out Party all
then-existing Third Party agreements that relate solely to the Royalty Product, in the Territory,
in the Field and are reasonably necessary for the Non-Opt-Out Party to continue researching,
Developing, Manufacturing, or Commercializing such Royalty Product in the Territory, in the Field;
provided, however, that the Opt-Out Party shall be required to assign any such agreement solely to
the extent assignment is permitted by such agreement provided that the Opt-Out Party uses Diligent
Efforts to obtain any consent necessary for such assignment, and the Opt-Out Party is not required
to pay any consideration or commence litigation in order to effect an assignment of any such
agreement to the Non-Opt-Out Party;

 

			
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               (iv) the Opt-Out Party shall transfer and assign to the Non-Opt-Out Party, in the form and
format in which such materials are maintained by the Opt-Out-Party in the ordinary course of
business, all Regulatory Materials for such Royalty Product, in the Territory, in the Field, that
are Controlled by the Opt-Out-Party or its Affiliates or permitted sublicensees; the Non-Opt-Out
Party shall have the right, without any additional consideration, to use any and all such data and
reports supplied by the Lead Regulatory Party under this Section 7.5(b)(iv) or pursuant to Section
4.1 in connection with the Development, Manufacture and/or Commercialization of such Royalty
Product in the Field, in the Territory in accordance with the terms of this Agreement, including
the incorporation of such data or reports in any regulatory submissions; and the Opt-Out Party’s
rights to participate in regulatory activities and meetings shall terminate;

               (v) all Committees except the JPC shall cease to have any rights, obligations or
decision-making capabilities with respect to such Royalty Product and, if there are no
Collaboration Products still being pursued at such time, shall disband until such time, if ever,
that a Collaboration Product is being pursued. All decisions that were made by such Committees
under this Agreement with respect to the Royalty Product prior to the Opt-Out Effective Date shall
thereafter be made solely by the Non-Opt-Out Party consistent with such Party’s obligations under
Section 7.5(b)(i). The JPC shall continue subject to Section 10.3 unless a Party has exercised or
is deemed to have exercised its Opt-Out Option in respect of all Collaboration Products, in which
case all decisions that were made by the JPC prior to the Opt-Out Effective Date shall be made
solely by the Non-Opt-Out Party consistent with such Party’s obligations under Section 7.5(b)(i);

               (vi) if the Opt-Out Party is the Lead Manufacturing Party of the Royalty Product(s), as part
of and during the period of the Transition Assistance (1) the Non-Opt-Out Party shall have the
right to require the Opt-Out Party to continue supplying Bulk API and finished Product for such
Royalty Product(s) under the terms of Article 6 for a period of up to eighteen (18) months
(provided that the Non-Opt-Out Party shall use Diligent Efforts to find one or more alternative
suppliers for Bulk API and finished Product as soon as reasonably possible following the exercise
of the Opt-Out Option), and (2) the Non-Opt-Out Party shall have the right to obtain transfer, and
the Opt-Out-Party shall have the obligation to effect transfer, without undue delay, of any and all
manufacturing technology included in the Facet Applied Know-How or Trubion Know-How, as applicable,
that is reasonably necessary to enable the Non-Opt-Out Party to Manufacture, or have Manufactured
such Royalty Product(s). The Non-Opt-Out Party automatically owns one-half (1/2) of any or all of
the inventory in existence as of the Opt-Out Effective Date of Bulk API and/or finished Product for
such Royalty Product (such inventory, the “Existing Inventory”). In addition, the Non-Opt-Out
Party shall have the right to purchase the other half of the Existing Inventory from the Opt-Out
Party by reimbursing the Opt-Out Party for the Manufacturing Costs with respect to such Existing
Inventory. The Non-Opt-Out Party shall notify the Opt-Out Party within [ * ] after the Effective
Opt-Out Date whether the Non-Opt-Out Party elects to exercise such right to purchase the other half
of the Existing Inventory;

               (vii) the Opt-Out Party shall, as promptly as commercially practicable, assign to the
Non-Opt-Out Party all right, title and interest in and to the Marks owned by the Opt-Out Party that
were used or intended to be used with the Royalty Products (excluding any

 

			
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such Marks that include, in whole or part, any corporate name or logo of the Opt-Out Party or
its Affiliates or permitted sublicensees), including any goodwill associated therewith. For the
avoidance of doubt, only those Marks that have been (A) identified as the single designated lead
candidate Mark for a non-commercialized Royalty Product, or (B) actually used in connection with a
Commercialized Royalty Product, shall be assigned. The Non-Opt-Out Party shall be responsible for
recording such assignment in the Territory with the appropriate Governmental Authority and will
bear all costs associated with such assignment and recordation. The Opt-Out Party shall cooperate
in facilitating such assignment and recordation by timely executing all necessary documents
provided to it by the Non-Opt-Out Party;

               (viii) in lieu of the Product Profit payments it would have received if the Opt-Out Party had
not exercised its Opt-Out Option or the Opt-Out Party had not been deemed to have exercised its
Opt-Out Option under Section 14.2(b) with respect to such Royalty Product, the Opt-Out Party shall
receive from the Non-Opt-Out Party royalties on the Net Sales of the Royalty Product(s) as provided
for under Section 9.5;

               (ix) the Opt-Out Party shall use Diligent Efforts to effect the assignment or the granting of
a sublicense or equivalent right of access to the Non-Opt-Out Party, whether through novation or
sublicensing of such contracts or otherwise, of any and all rights under any contract between the
Opt-Out Party and any Third Party that are reasonably necessary for the Non-Opt-Out Party to
continue with Development or Commercialization of such Royalty Product, and the Non-Opt-Out Party
shall reasonably cooperate in connection therewith, provided that if such assignment, novation or
sublicense is not permissible, the Parties shall discuss in good faith potential alternatives that
would enable the Non-Opt-Out Party to exercise at the Non-Opt-Out Party’s expense (on a
pass-through basis) the rights and perform the obligations of the Opt-Out Party under such
contracts with respect to such Royalty Product while minimizing the continuing obligations of the
Opt-Out Party under such contract with respect to such Royalty Product, and, unless the Non-Opt-Out
Party informs the Opt-Out Party in writing that it is [ * ] in [ * ] such [ * ] and [ * ] such [ *
] or it is [ * ] for the [ * ] to [ * ], the Opt-Out Party shall [ * ] such [ * ] in [ * ] for the
[ * ] of such [ * ] to [ * ] the [ * ] to [ * ] with [ * ] or [ * ] of such [ * ]; and

               (x)

                    a. in the event of an Opt-Out pursuant to Section 7.2 or Section 8.5, the Non-Opt-Out Party
shall reimburse the Opt-Out Party for [ * ] of the reasonable expenses incurred by the Opt-Out
Party in the course of performing its transfer obligations pursuant to Sections 7.5(b)(iii),
7.5(b)(iv), 7.5(vi)(2) and 7.5(vii), provided that any request for reimbursement of such expenses
is accompanied by invoices, and/or such other appropriate supporting documentation evidencing in
reasonable detail the expenses for which reimbursement is allowed under this Section 7.5(b)(x); and

                    b. in the event of an Opt-Out pursuant to Section 7.3, the Non-Opt-Out Party shall reimburse
the Opt-Out Party for [ * ] of the reasonable expenses incurred by the Opt-Out Party in the course
of performing its transfer obligations pursuant to Sections 7.5(b)(iii), 7.5(b)(iv), 7.5(vi)(2) and
7.5(vii), provided that any request for reimbursement of such expenses is accompanied by invoices,
and/or such other appropriate

 

			
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supporting documentation evidencing in reasonable detail the expenses for which reimbursement
is allowed under this Section 7.5(b)(x).

	8.	 	LICENSES.

     8.1 License to Facet. Subject to the terms and conditions of this Agreement, Trubion,
effective as of the Signing Date, hereby grants to Facet an exclusive license (exclusive even as to
Trubion, except to the extent necessary for Trubion to perform its obligations and exercise its
rights under this Agreement), with the right to grant sublicenses in accordance with the provisions
of Section 8.3, under the Trubion Patent Rights and Trubion Know-How, to research Develop, use,
make, Manufacture, import, export distribute, market, offer for sale, sell and Commercialize
Products, in the Field, in the Territory in accordance with the terms of this Agreement.
Notwithstanding the foregoing, the rights granted to Facet under this Section 8.1 shall terminate
with respect to an Opt-Out Product effective (a) as of the Opt-Out Effective Date for such Product
if Facet exercises or is deemed to have exercised its Opt-Out Option, and (b) [ * ] after the [ * ]
for such [ * ] if [ * ] its [ * ] pursuant to Section [ * ] or [ * ] and [ * ] has [ * ] a [ * ]
for such [ * ]. For clarity, the rights granted to Facet under this Section 8.1 shall remain in
full force and effect if Trubion is deemed to have exercised its Opt-Out Option pursuant to Section
14.2(b).

     8.2 Licenses to Trubion.

          (a) Subject to the terms and conditions of this Agreement, Facet, effective as of the Signing
Date, hereby grants to Trubion a license, with the right to grant sublicenses in accordance with
the provisions of Section 8.3, under the Facet Patent Rights and the Facet Know-How, which license
shall be non-exclusive, except with respect to Facet’s interest in Joint Patent Rights for which
such license shall be co-exclusive, solely for the purpose of, and limited to, Trubion’s exercise
of its rights and performance of its obligations under this Agreement, to Develop, use, make,
Manufacture, import, export, distribute, market, offer for sale, sell and Commercialize
Collaboration Products, in the Field, in the Territory in accordance with the terms of this
Agreement.

          (b) Subject to the terms and conditions of this Agreement, Facet, effective as of the date of
the delivery or deemed delivery of Trubion’s Pursuit Notice with respect to an Opt-Out Product,
hereby grants to Trubion an exclusive, royalty-bearing license, with the right to grant sublicenses
in accordance with the provisions of Section 8.3, under the Facet Applied Technology, to Develop,
use, make, Manufacture, import, export, distribute, market, offer for sale, sell and Commercialize
such Royalty Product, in the Field, in the Territory in accordance with the terms of this
Agreement.

     8.3 Sublicensing.

          (a) No Sublicensing. Except as set forth in Sections 8.3(b) and 8.3(c), neither Party shall
sublicense any of the rights granted to it under this Agreement to any Third Party without the
prior written consent of the other Party, provided that either Party may sublicense such rights:
(i) to its Affiliates, further provided that any such sublicense to an Affiliate shall immediately
terminate if and when such entity ceases to be an Affiliate of such Party, and (ii)

 

			
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omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

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subject to Sections 3.5(a) and 3.5(b), to subcontractors or consultants to perform such
Party’s assigned Development, Manufacturing or Commercialization responsibilities under this
Agreement with respect to Collaboration Products, further provided that (A) such Party remains
responsible for the work allocated to, and payment to, such subcontractors and consultants to the
same extent it would if it were doing such work itself, (B) such sublicense shall be subject and
subordinate to, and consistent with, the terms and conditions of this Agreement, (C) such
sublicense shall not in any way diminish, reduce or eliminate any of such Party’s obligations under
this Agreement, and (D) such Party uses Diligent Efforts to include in such sublicense agreement a
provision which permits such Party to provide a copy of such sublicense agreement to the other
Party, which copy may be redacted to exclude confidential information not related to the applicable
Collaboration Product. Unless prohibited by the terms of the sublicense, such Party shall provide
the other Party with a copy of each such sublicense agreement entered into after the Signing Date
within [ * ] after the execution thereof, which agreement may be redacted to exclude confidential
information not related to the applicable Collaboration Product.

          (b) Joint Sublicense. The Parties acknowledge that they may, upon mutual agreement, both
grant sublicenses to a Third Party with respect to a particular Collaboration Product, including
with respect to a particular country or indication.

          (c) Upon Opt-Out. At any time after its delivery or deemed delivery of a Pursuit Notice with
respect to a particular Royalty Product, the Non-Opt-Out Party may grant to one or more Third
Parties sublicenses of some or all of the rights granted to it under Section 8.1 or 8.2(b), as
applicable, but only with respect to such Royalty Product; provided that the Non-Opt-Out Party
shall execute a written agreement with each such permitted sublicensee, which sublicense (i) shall
be subject and subordinate to, and consistent with, the terms and conditions of this Agreement,
(ii) shall not in any way diminish, reduce or eliminate any of the Non-Opt-Out Party’s obligations
under this Agreement, (iii) shall require each such permitted sublicensee to comply with all
applicable terms of this Agreement, including to keep books and records, and (iv) shall permit the
Non-Opt-Out Party to audit (either directly or through an independent auditor) such books and
records. The Non-Opt-Out Party shall provide the Opt-Out Party with a copy of each such sublicense
agreement within [ * ] after the execution thereof. Such copy may be redacted to exclude
confidential, non-Royalty Product-related information and financial information (other than such
financial information that is necessary for assessing the obligations to the Opt-Out Party under
this Agreement). Upon the Opt-Out Party’s request and at the Opt-Out Party’s expense, the
Non-Opt-Out Party shall exercise its right to conduct an audit of a sublicensee’s books and records
pertaining to the sale of the applicable Royalty Product under any such sublicense agreement at the
next time that conducting such an audit is permissible under such sublicense agreement. The
Non-Opt-Out Party shall provide the Opt-Out Party with a copy of the report of the findings made in
any such audit. If such audit reveals that such sublicensee has understated its Net Sales by [ * ]
or more, the Non-Opt-Out Party shall be responsible for the reasonable out-of-pocket costs of the
Opt-Out Party in conducting the audit. The Non-Opt-Out Party shall remain responsible for its
obligations hereunder and for the performance of its sublicensees (including, without limitation,
making all payments due to the Opt-Out Party by reason of any Net Sales of Royalty Product), and
shall ensure that any such sublicensees comply with all relevant provisions of this Agreement. In
the event of any uncured material breach by any sublicensee under a sublicense agreement that would
constitute a material breach of the Non-Opt-Out Party’s obligations under this Agreement, the
Non-Opt-Out Party

 

			
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will promptly inform the Opt-Out Party in writing and shall take such action which in the
Non-Opt-Out Party’s reasonable business judgment will address such default; provided, however, any
such uncured material breach by such sublicensee of an obligation that would constitute a material
breach of the Non-Opt-Out Party’s obligations under this Agreement shall be deemed an uncured
material breach of the Non-Opt-Out Party hereunder unless the Non-Opt-Out Party cures such material
breach within the time provided under Section 14.2.

     8.4 No Implied Rights. Except as expressly provided in this Agreement, neither Party shall be
deemed by estoppel or implication to have granted the other Party any license or other right with
respect to any intellectual property of such Party.

     8.5 Exclusivity. Except for the Development and Commercialization of Products pursuant to the
terms of this Agreement, during the Term neither Party shall Develop or Commercialize any protein
therapeutic, including any [ * ], that binds to the CD37 Antigen (or a [ * ]) [ * ] of [ * ] and
wherein such protein therapeutic is [ * ] or [ * ] to [ * ] its [ * ] through [ * ] the [ * ] (or a
[ * ]) (a “Competing Program”). In the event that, due to a Change of Control of a Party, such
Party, or its successor in interest, is conducting a Competing Program during the Term of this
Agreement, then such Party, or its successor in interest, shall either (a) exercise its Opt-Out
Option with respect to all Collaboration Products by providing an Opt-Out Notice to the other
Party; or (b) divest such Competing Program to a Third Party, in each case within [ * ] of such
Change of Control.

     8.6 [ * ]. Each Party shall promptly bring to the attention of the JSC (or the other Party if
there is no JSC in place at the time) any [ * ] that such Party wishes to Develop and Commercialize
during the Term. Upon the recommendation of the JSC (or the mutual agreement of the Parties if
there is no JSC in place at the time), the Parties shall negotiate in good faith an agreement to
Develop and Commercialize such [ * ] on commercially reasonable terms.

     8.7 Third Party Licenses. If the JPC determines that it is advisable or necessary to obtain a
license (“Future Third Party License”) to any intellectual property right that is owned or
controlled by a Third Party and is reasonably necessary or useful to the Development, Manufacture,
or Commercialization of a Collaboration Product, the JPC shall so advise the JSC. If the JSC
determines to seek a license, the JSC shall designate a Party to negotiate the terms on which such
a Third Party license would be granted and to serve as the primary point of contact with the
applicable Third Party licensor following the execution of the license agreement. Upon approval of
the terms of such Future Third Party License by the JSC, the designated Party may execute such
Future Third Party License and any payments that become due pursuant to a Future Third Party
License agreement executed pursuant to this Section 8.7 will be treated as Development Costs or
Commercialization Costs, as applicable, if incurred prior to the Opt-Out Effective Date or after
the Opt-Out Effective Date but with respect to a Collaboration Product. If a Party delivers or is
deemed to have delivered a Pursuit Notice for a Collaboration Product, any payments arising under a
Future Third Party License from the Development, Manufacturing or Commercialization of the
applicable Royalty Product shall be paid by such Non-Opt-Out Party, subject to Section 9.5(e)(iii).

 

			
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9. CONSIDERATION.

     9.1 Upfront Payment. Facet shall pay to Trubion Twenty Million Dollars ($20,000,000.00)
within ten (10) days after the Signing Date, which payment shall be non-refundable and
non-creditable.

     9.2 Equity Investment. Facet and Trubion have entered into the Stock Purchase Agreement
attached hereto as Exhibit C, pursuant to which Facet will purchase from Trubion and
Trubion will sell to Facet Ten Million Dollars ($10,000,000.00) of newly issued shares of common
stock of Trubion at a purchase price per share equal to One Hundred Thirty-Five Percent (135%) of
the average closing price of a share of common stock of Trubion over the sixty (60) trading days
prior to the Signing Date provided that such purchase price (including the 35% premium) shall not
be greater than $[ * ]/share or lower than $[ * ]/share of common stock of Trubion.

     9.3 Development Milestone Payments. Facet shall make milestone payments (each a “Milestone
Payment”) to Trubion based on the first achievement of each milestone event in the Field, in the
Territory for each Product as set forth in this Section 9.3. No Milestone Payment shall be made
twice with respect to the same Product. For the purposes of this Section 9.3, two Products are
deemed the “same Product” if one Product contains, as its active pharmaceutical ingredient, (i) the
same [ * ] or [ * ] that is [ * ] in the [ * ], (ii) a [ * ] that is a [ * ] or [ * ] form of the [
* ] or [ * ] that is [ * ] in the [ * ] or (iii) a [ * ] that is a [ * ] or [ * ] form of a [ * ]
or [ * ] from which the [ * ] in the [ * ] was [ * ] or [ * ]. Facet shall pay to Trubion the
amounts set forth below, within [ * ] after the first achievement of the corresponding milestone
event with respect to the Product. Each Milestone Payment is non-refundable and non-creditable
against any other payments due hereunder, provided that if the Development of a Product is
abandoned, any Milestone Payments made with respect to such abandoned Product may be credited
against the corresponding Milestone Payments payable on a Product which achieves such milestones
after the abandonment of the other Product. For the purposes of this Section 9.3, the “[ * ]” of a
Clinical Trial shall occur upon the [ * ] of the [ * ] in such [ * ], “[ * ]” and “[ * ]” shall be
[ * ] by the [ * ] in advance with respect to such [ * ] in the [ * ] or, following [ * ] for the
applicable [ * ], [ * ] by the [ * ] in advance with respect to such [ * ] in [ * ] for the [ * ].
Notwithstanding anything to the contrary in this Agreement, if Trubion is deemed pursuant to
Section 14.2(b) to have exercised its Opt-Out Option with respect to all Products on account of an
uncured material breach by Trubion, the amount of the milestone payments due pursuant to this
Section 9.3 with respect to milestone events achieved by all Products after Facet has provided
Trubion with written notice of continuation in accordance with Section 14.2(b) shall be reduced by
[ * ].

 

			
	[ * ] =	 	 Certain confidential information contained in this document, marked by brackets, has been
omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

51

 

	 	 	 	 	 
	Milestone Event	 	Milestone Payment
	 
	[ * ] of the [ * ] (includes [ * ])
	 	$	[ * ]	 
	 
	 	 	 	 
	[ * ] of the [ * ] in [ * ] (includes [ * ])
	 	$	[ * ]	 
	 
	 	 	 	 
	[ * ] of the [ * ] in [ * ] (includes [ * ])
	 	$	[ * ]	 
	 
	 	 	 	 
	[ * ] of [ * ] by [ * ] in [ * ]
	 	$	[ * ]	 
	 
	 	 	 	 
	[ * ] of [ * ] by [ * ] in [ * ]
	 	$	[ * ]	 
	 
	 	 	 	 
	[ * ] of [ * ] by [ * ] in [ * ]
	 	$	[ * ]	 
	 
	 	 	 	 
	[ * ] of [ * ] by [ * ] in [ * ]
	 	$	[ * ]	 
	[ * ] of [ * ] by [ * ] in [ * ]
	 	$	[ * ]	 
	 
	 	 	 	 
	[ * ] of [ * ] by [ * ] in [ * ]
	 	$	[ * ]	 
	[ * ] of the [ * ] for the [ * ]
	 	$	[ * ]	 
	 
	 	 	 	 
	[ * ] of the [ * ] for the [ * ]
	 	$	[ * ]	 
	 
	 	 	 	 
	[ * ] or [ * ] of the [ * ] in the [ * ] for the [ * ]
	 	$	[ * ]	 
	 
	 	 	 	 
	[ * ] or [ * ] of the [ * ] in the [ * ] for the [ * ]
	 	$	[ * ]	 
	[ * ] of the [ * ] in [ * ] for the [ * ]
	 	$	[ * ]	 
	[ * ]
	 	$	[ * ]	 

     9.4 Sharing of Product Profit.

          (a) Allocation. Facet and Trubion shall share equally in Product Profit (which, for the
avoidance of doubt, includes sharing of losses in a given period if the calculation of Product
Profit for such period is negative) arising from the sale of each Collaboration Product in the
Field in the Territory.

          (b) FTE Records and Calculations. Each Party shall record its FTE effort for the
Commercialization of each Collaboration Product to the extent that such FTE efforts are included in
Commercialization Costs that are, or may in the future be, shared under this Agreement, and shall
report such FTE effort to the JCC, on a Calendar Quarterly basis, in each case in a manner that
allocates such FTE effort to the extent practicable to each applicable Collaboration Product.
Except to the extent provided herein, each Party shall calculate and maintain records of FTE effort
incurred by it in the same manner as used for other products commercialized by such Party in
accordance with a methodology approved by the JSC. The JFC shall facilitate any reporting
hereunder.

          (c) Commercialization Costs Accounts. Each Party shall charge all Commercialization Costs as
incurred by it or its Affiliates on its books and records in connection with each Commercialization
Plan. Each Party shall provide the other Party with an interim quarterly report of monthly
estimates for the current Calendar Quarter charges within [ * ] after the end of the second
calendar month in each Calendar Quarter.

 

			
	[ * ] =	 	 Certain confidential information contained in this document, marked by brackets, has been
omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

52

 

          (d) Other Expenses. Any expenses incurred by a Party for Commercialization activities that do
not fall within the definitions of Commercialization Costs shall be borne solely by such Party
unless the JSC determines otherwise. In addition, each Party shall bear all costs incurred pursuant
to the Commercialization Plan, that exceed the portion of the Commercialization Budget allocated to
the Party with respect to the relevant Calendar Quarter by more than [ * ] unless otherwise
approved by the JSC.

          (e) Pre-existing Obligations. Unless otherwise determined by the JSC, any manufacturing
obligations in existence prior to the Signing Date, such as manufacturing capacity reservation or
other obligations described in Section 6.3, other than those disclosed in writing by the obligated
Party prior to the Signing Date and specifically agreed upon by the Parties, will not be considered
Commercialization Costs and will not be subject to expense sharing.

          (f) Reporting. Within [ * ] after the end of each Calendar Quarter, commencing with the first
Calendar Quarter in which the Parties are implementing a Commercialization Plan for a particular
Collaboration Product, each Party shall report to the JCC and the JFC its gross sales and
Commercialization Costs for such Collaboration Product in the Territory. In addition, each Party
shall provide the JCC and the JFC with a monthly statement on a Product-by-Product and
country-by-country basis of the amount of gross sales of Collaboration Products.

          (g) Payment. Within [ * ] after receipt of such reports, the JFC shall provide for such
Collaboration Product a consolidated financial statement setting forth the Product Profit for such
Collaboration Product and calculating each Party’s fifty percent (50%) share of such Product
Profit. Thereafter the following remittance obligations shall apply for such Collaboration Product
depending on whether such Product Profit is positive or negative:

               (i) If there is positive Product Profit for such Calendar Quarter, then one Party shall make a
payment to the other Party within [ * ] following delivery of the financial statement referenced
above in an amount that will cause each Party to have received an equal share of the Product Profit
for such Calendar Quarter.

               (ii) If there is negative Product Profit for such Calendar Quarter, then one Party shall make
a payment to the other Party so that each Party will bear an equal share of the Product Profit for
such Calendar Quarter. Such payment shall be made within [ * ] following delivery of the financial
statement referenced above.

          (h) Records. Each Party shall keep detailed records of the Commercialization Costs it incurs,
including all supporting documentation for such expenses, and remits for payment. Each Party shall
keep such records for at least [ * ] after the date that such expense was incurred.

     9.5 Royalties.

          (a) Base Royalties.

 

			
	[ * ] =	 	 Certain confidential information contained in this document, marked by brackets, has been
omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

53

 

               (i) Trubion Royalties. Subject to Section 9.5(e), if Trubion has exercised its Opt-Out Option
pursuant to Section 7.2, Facet shall pay Trubion royalties on the Net Sales of Royalty Products
during the applicable Royalty Period as follows:

	 	 	 	 	 
	Date of Trubion Opt-Out Notice:	 	Royalty Rate:
	 
	At any time after [ * ] from the [ * ] and before the [ * ]
for the [ * ]
	 	 	[ * ]	%
	Within [ * ] after the [ * ] for [ * ]
	 	 	[ * ]	%
	Within [ * ] after the [ * ] for [ * ]
	 	 	[ * ]	%

               (ii) Facet Royalties. Subject to Section 9.5(e) if Facet has exercised its Opt-Out Option
pursuant to Section 7.2 Trubion shall pay Facet royalties on the Net Sales of Royalty Products
during the applicable Royalty Period as follows:

	 	 	 	 	 
	Date of Facet Opt-Out Notice:	 	Royalty Rate:
	 
	Within [ * ] after the [ * ] for the [ * ]
	 	 	[ * ]	%
	Within [ * ] after the [ * ] for [ * ]
	 	 	[ * ]	%

          (b) Royalties after Opt-Out due to Competing Program. Subject to Section 9.5(e), if the
Opt-Out Party exercised its Opt-Out Option pursuant to Section 8.5 (i.e., due to a Competing
Program following a Change of Control of the Opt-Out Party), the Non-Opt-Out Party shall pay the
Opt-Out Party royalties on the Net Sales of Royalty Products during the applicable Royalty Period,
as follows:

	 	 	 	 	 
	Date of Opt-Out Notice:	 	Royalty Rate:
	 
	Before the [ * ] of the [ * ]
	 	 	[ * ]	%
	After the [ * ] of [ * ]
	 	 	[ * ]	%

          (c) Royalties after Opt-Out Following Change of Control. Subject to Section 9.5(e), if the
Opt-Out Party exercised its Opt-Out Option pursuant to Section 7.3 following a Change of Control of
the Non-Opt-Out Party, the Non-Opt-Out Party (or its successor in interest) shall pay the Opt-Out
Party royalties on the Net Sales of Royalty Products during the applicable Royalty Period, as
follows:

 

			
	[ * ] =	 	 Certain confidential information contained in this document, marked by brackets, has been
omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

54

 

	 	 	 	 	 
	Date of Opt-Out Notice:	 	Royalty Rate:
	 
	Before the [ * ] of the [ * ] for the [ * ]
	 	 	[ * ]	%
	After [ * ] of the [ * ] for the [ * ] and before the [ * ]
for [ * ]
	 	 	[ * ]	%
	After the [ * ] for [ * ] and before the [ * ] for [ * ]
	 	 	[ * ]	%
	After the [ * ] for [ * ] and before the [ * ] of [ * ]
	 	 	[ * ]	%
	After the [ * ] of [ * ]
	 	 	[ * ]	%

          (d) Royalties after Opt-Out Following Uncured Breach.

               (i) Trubion Royalties. Subject to Section 9.5(e), if Trubion is deemed pursuant to Section
14.2(b) to have exercised its Opt-Out Option with respect to all Products on account of an uncured
material breach by Trubion, Facet shall pay Trubion royalties on the Net Sales of Royalty Products
during the applicable Royalty Period, as follows:

	 	 	 	 	 
	Date of Trubion Deemed Opt-Out:	 	Royalty Rate:
	 
	Before the [ * ] of the [ * ] for the [ * ]
	 	 	[ * ]	%
	After [ * ] of the [ * ] for the [ * ] and before the [ * ]
for [ * ]
	 	 	[ * ]	%
	After the [ * ] for [ * ] and before the [ * ] for [ * ]
	 	 	[ * ]	%
	After the [ * ] for [ * ] and before the [ * ] of [ * ]
	 	 	[ * ]	%
	After the [ * ] of [ * ]
	 	 	[ * ]	%

               (ii) Facet Royalties. Subject to Section 9.5(e), if Facet is deemed pursuant to Section
14.2(b) to have exercised its Opt-Out Option with respect to all Products on account of an uncured
material breach by Facet, Trubion shall pay Facet royalties on the Net Sales of Royalty Products
during the applicable Royalty Period, as follows:

 

			
	[ * ] =	 	 Certain confidential information contained in this document, marked by brackets, has been
omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

55

 

	 	 	 	 	 
	Date of Facet Deemed Opt-Out:	 	Royalty Rate:
	 
	Before the [ * ] of the [ * ] for the [ * ]
	 	 	[ * ]	%
	After [ * ] of the [ * ] for the [ * ] and before the [ * ]
for [ * ]
	 	 	[ * ]	%
	After the [ * ] for [ * ] and before the [ * ] for [ * ]
	 	 	[ * ]	%
	After the [ * ] for [ * ] and before the [ * ] of [ * ]
	 	 	[ * ]	%
	After the [ * ] of [ * ]
	 	 	[ * ]	%

          (e) Reduced Royalty Rate.

               (i) If a Royalty Product is generating Net Sales in a country during the applicable Royalty
Period at a time when there is no Valid Claim covering such Royalty Product in such country of sale
within the Trubion Patent Rights or the Facet Applied Patent Rights, then the royalty rate
applicable to Net Sales of such Royalty Product in such country shall be reduced by [ * ] percent
([ * ]%) of the applicable royalty rate set forth in Section 9.5(a)-(d).

               (ii) If a Royalty Product is generating Net Sales in a country during the applicable Royalty
Period at a time when a competing product is being actively marketed and sold in such country, then
the royalty rate applicable to Net Sales of such Royalty Product in such country shall be reduced
by [ * ] percent ([ * ]%) of the applicable royalty rate set forth in Section 9.5(a)-(d). For
purposes of this Section 9.5(e)(ii), “competing product” shall mean a third party protein
therapeutic that (a) [ * ] the [ * ] (or a [ * ]) [ * ] of [ * ] and wherein such protein
therapeutic is [ * ] or [ * ] or [ * ] to [ * ] through [ * ] the [ * ] (or a [ * ]), and (b) is [
* ] for the [ * ] the [ * ].

               (iii) The Non-Opt-Out Party may, subject to Section 9.5(e)(iv), deduct from the royalties it
would otherwise owe to the Opt-Out Party pursuant to this Section 9.5 for Third Party licenses
entered into after the Signing Date, including Future Third Party Licenses, an amount equal to [ *
] percent ([ * ]%) of the amounts paid to Third Parties in consideration for intellectual property
rights that the Non-Opt-Out Party reasonably believes are necessary in connection with the
Development, Manufacture or Commercialization of a Royalty Product in the Field in the Territory.

               (iv) During the Royalty Period, the operation of Sections [ * ] and [ * ] individually or in
combination shall not reduce by more than [ * ] percent ([ * ]%) the royalties that would otherwise
have been due under in Section 9.5(a)-(d).

          (f) Expiration of Royalty Period. After the expiration of the Royalty Period for any Royalty
Product in any country in the Territory, no further royalties shall be payable in respect of sales
of such Royalty Product in such country and thereafter the licenses granted to the Non-Opt-Out
Party under Section 8.1 or 8.2, as applicable, with respect to such Royalty Product in such country
shall be fully paid-up, perpetual, irrevocable, royalty-free, non-exclusive licenses.

 

			
	[ * ] =	 	 Certain confidential information contained in this document, marked by brackets, has been
omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

56

 

          (g) Cumulative Royalties. The obligation to pay royalties under Section 9.5 shall be imposed
only once with respect to a single unit of a Royalty Product, regardless of how many Valid Claims
included within the Trubion Patent Rights, or Facet Applied Patent Rights would, but for this
Agreement, be infringed by the Manufacture, use, import, offer for sale or sale of such Royalty
Product in the countr(y)ies in the Territory of such Manufacture, use or sale.

          (h) Royalty Product Reports and Payments. During the Royalty Period, within [ * ] after the
end of each Calendar Quarter, the Non-Opt-Out Party shall deliver to the Opt-Out Party a report
setting forth for such Calendar Quarter the following information, on a Royalty Product-by-Royalty
Product and country-by-country basis: (a) the gross sales amount (by the Non-Opt-Out Party, its
Affiliates and permitted sublicensees) for each Royalty Product sold in the Field in the Territory,
on a country-by-country basis; (b) the Net Sales for each Royalty Product; and (c) the royalty
amount due hereunder for the sale of each Royalty Product. No such reports shall be due for any
Royalty Product before the First Commercial Sale of such Royalty Product in the Territory. The
total royalty due for the sale of Royalty Products during such Calendar Quarter shall be remitted
at the time such report is made.

     9.6 Taxes and Withholding. All payments due from one Party to another under this Agreement
will be made without any deduction or withholding for or on account of any tax unless such
deduction or withholding is required by applicable Laws to be assessed against the receiving Party.
If the paying Party is so required to deduct or withhold, the paying Party will (a) promptly
notify the receiving Party of such requirement, (b) pay to the relevant authorities the full amount
required to be deducted or withheld promptly upon the earlier of determining that such deduction or
withholding is required or receiving notice that such amount has been assessed against the
receiving Party, (c) promptly forward to the receiving Party an official receipt (or certified
copy) or other documentation reasonably acceptable to the receiving Party evidencing such payment
to such authorities, and (d) otherwise reasonably cooperate with the receiving Party in connection
with the receiving Party’s attempts to obtain favorable tax treatment and credit therefor (where
appropriate) in accordance with applicable Laws.

     9.7 Currency. All amounts payable and calculations hereunder shall be in Dollars. Conversion
of sales recorded in local currencies to Dollars will be performed in a manner consistent with a
Party’s normal practices used to prepare its financial statements and consistent with GAAP,
provided that such practices use a widely accepted source of published exchange rates (and are
approved by the JCC as applicable).

     9.8 Interest on Past Due Payments. If either Party fails to pay any payment due under this
Agreement on or before the date such payment is due, as provided in this Agreement, such late
payment shall bear interest, to the extent permitted by applicable Law, at the [ * ] as [ * ] from
time to time [ * ], effective for the first date on which payment was delinquent and calculated on
the number of days such payment is overdue or, if such rate is [ * ], as [ * ] as the Parties
agree.

     9.9 Maintenance of Records; Audits; Consolidation.

          (a) Record Keeping. Each Party shall keep accurate books and accounts of record in accordance
with GAAP in connection with the Development, Manufacture and

 

			
	[ * ] =	 	 Certain confidential information contained in this document, marked by brackets, has been
omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

57

 

Commercialization of Products, and the calculation of payments to be made under this Agreement
in sufficient detail to permit accurate determination of all amounts necessary for verification of
royalties and other payments to be paid from one Party to another under this Agreement. Each Party
shall maintain such records for a period of at least [ * ] after the end of the Calendar Year in
which they were generated.

          (b) Audits. Upon thirty (30) days prior written notice, a Party (the “Auditing Party”) may
conduct and the other Party (the “Audited Party”) shall permit an independent certified public
accounting firm of nationally recognized standing selected by the Auditing Party and reasonably
acceptable to the Audited Party, to examine, at the Auditing Party’s sole expense, the relevant
books and records of the Audited Party as may be reasonably necessary to verify the accuracy of (a)
reports for Development Costs, (b) Manufacturing Costs, (c) Commercialization Costs and (d) the
reports submitted by the Audited Party in accordance with this Agreement in connection with the
payment of royalties and other amounts hereunder. An examination by the Auditing Party under this
Section 9.9(b) shall occur not more than once in any Calendar Year and shall be limited to the
pertinent books and records for any Calendar Year ending not more than [ * ] before the date of the
request. The accounting firm shall be provided access to such books and records at the Audited
Party’s facility(ies) where such books and records are normally kept and such examination shall be
conducted during the Audited Party’s normal business hours. The Audited Party may require the
accounting firm to sign a standard non-disclosure agreement before providing the accounting firm
access to the Audited Party’s facilities or records. Upon completion of the audit, the accounting
firm shall provide both the Audited Party and the Auditing Party a written report disclosing
whether the reports submitted by the Audited Party are correct or incorrect, whether the amounts
paid are correct or incorrect, and in each case, the specific details concerning any discrepancies.
No other information shall be provided to the Auditing Party.

          (c) Underpayments/Overpayments. If such accounting firm concludes that additional royalties
or other payments were due to the Auditing Party, the Audited Party shall pay to the Auditing Party
the additional amounts within [ * ] of the date the Audited Party receives such accountant’s
written report so concluding. If an underpayment exceeds [ * ] percent ([ * ]%) of the amounts
that were to be paid to the Auditing Party, the Audited Party also shall reimburse the Auditing
Party for all costs and reasonable out-of-pocket expenses incurred in conducting the audit. If
such accounting firm concludes that the Audited Party overpaid the Auditing Party, the Auditing
Party, within [ * ] of the date the Auditing Party receives such account’s report so concluding,
will refund such overpayments to the Audited Party less the reasonable out-of-pocket costs incurred
by the Auditing Party in conducting the audit.

          (d) Confidentiality. All financial information of the Audited Party with respect to a Royalty
Product which is subject to review under this Section 9.9 shall be deemed to be the Audited Party’s
Confidential Information subject to the provisions of Article 11, and the Auditing Party shall not
disclose such Confidential Information to any Third Party or use such Confidential Information for
any purpose other than verifying payments to be made by the Audited Party with respect to such
Royalty Product; provided, however, that such Confidential Information may be disclosed by the
Auditing Party to Third Parties only to the extent necessary to enforce the Auditing Party’s rights
under this Agreement. All financial information of the Audited Party with respect to a
Collaboration Product which is subject to review under this

 

			
	[ * ] =	 	 Certain confidential information contained in this document, marked by brackets, has been
omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

58

 

Section 9.9 shall be deemed to be the Confidential Information of both Parties subject to the
provisions of Article

          (e) Consolidation. In the event that a Party is, in the opinion of its independent registered
accounting firm, reasonably required to consolidate or otherwise report in the financial statements
of such Party (the “Consolidating Party”), all or a portion of the financial performance of the
other Party (the “Consolidated Party”) for any financial reporting periods, then the Consolidating
Party shall promptly notify the Consolidated Party of such determination in writing, and the
Consolidated Party agrees to cooperate and promptly provide reasonable access to its books and
records in order for the Consolidating Party to fulfill its financial reporting obligations.

10. INTELLECTUAL PROPERTY.

     10.1 Ownership of Collaboration Inventions.

          (a) The JPC shall, within a reasonable time after the Signing Date, establish and oversee a
mutually agreeable procedure for (i) identifying and disclosing all inventions and Know-How
generated by one or both Parties, their Affiliates or their respective employees, agents, or
independent contractors in the course of conducting activities under this Agreement (“Collaboration
Inventions”); and (ii) determining inventorship of each such Collaboration Invention, provided that
such determination shall be made in accordance with United States patent laws.

          (b) Each Party shall solely own all Collaboration Inventions invented solely by its and/or its
Affiliates’ respective employees, agents and/or independent contractors.

          (c) All Collaboration Inventions invented jointly by one or more employees, agents, or
independent contractors of Trubion and/or its Affiliates and one or more employees, agents, or
independent contractors of Facet and/or its Affiliates (collectively, “Joint Inventions”) shall be
owned jointly by the Parties in accordance with joint ownership interests of co-inventors under
United States patent laws (that is, each Party shall have full rights to license, assign and
exploit such Joint Inventions (and any patents arising therefrom) anywhere in the world, without
any requirement of gaining the consent of, or accounting to, the other Party), subject to the
licenses granted herein and subject to any other intellectual property held by such other Party.

          (d) This Agreement is intended by the Parties to be entered into pursuant to 35 U.S.C. 103(c),
as such section may be amended from time to time. For clarity, Collaboration Inventions are
intended by the Parties to be subject to 35 U.S.C. 103(c)(1) and this Agreement is intended by the
Parties to be deemed a “joint research agreement” as defined in 35 U.S.C. 103(c)(3), as such
sections may be amended from time to time.

     10.2 Disclosure of Inventions. Each Party shall promptly disclose to the JPC all
Collaboration Inventions, including all invention disclosures or other similar documents submitted
to such Party by its, or its Affiliates’ employees, agents or independent contractors describing
Collaboration Inventions.

 

			
	[ * ] =	 	 Certain confidential information contained in this document, marked by brackets, has been
omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

59

 

     10.3 Prosecution of Patents.

          (a) Trubion Core Patent Rights. Except as otherwise provided in this Section 10.3, as between
the Parties, Trubion shall have the sole right and authority to prepare, file, prosecute (including
any oppositions, interferences, reissue proceedings, reexaminations and post-grant proceedings) and
maintain the Trubion Core Patent Rights in any jurisdiction in the Territory, provided that
decisions regarding any claims within the Trubion Core Patent Rights that claim the [ * ] or [ * ]
of [ * ] or [ * ] in the [ * ] and do not claim the [ * ] or [ * ] of [ * ] that is [ * ] shall be
made by the JPC. Trubion shall provide Facet (i) a reasonable opportunity to review and comment on
such filing and prosecution efforts regarding the Trubion Core Patent Rights in the Territory; (ii)
a copy of each material communication received from any patent authority in the Territory regarding
the Trubion Core Patent Rights, and (iii) drafts of any material filings or material responses to
be made to such patent authorities a reasonable amount of time in advance of submitting such
filings or responses. If Trubion determines in its sole discretion to abandon, cease prosecution or
not maintain any Trubion Core Patent Right anywhere in the Territory, then Trubion shall provide
Facet written notice of such determination at least [ * ] before any deadline for taking action to
avoid abandonment (or other loss of rights) and shall provide Facet with the opportunity to
prepare, file, prosecute and maintain such Trubion Core Patent Right in the affected countries of
the Territory on behalf of Trubion. If Facet desires Trubion to file, in a particular jurisdiction
in the Territory, a Trubion Core Patent Right that claims priority to (or is based on the subject
matter of) another Trubion Core Patent Right, Facet shall provide written notice to Trubion
requesting that Trubion file such patent application in such jurisdiction. If Facet provides such
written notice to Trubion, Trubion shall either (i) file and prosecute such patent application and
maintain any patent issuing thereon in such jurisdiction, or (ii) notify Facet that Trubion does
not desire to file such patent application and provide Facet with the opportunity to file and
prosecute such patent application and maintain any patent issuing thereon on behalf of Trubion.
Facet’s rights under this Section 10.3 with respect to any Trubion Core Patent Right licensed to
Trubion by a Third Party shall be subject to the rights of such Third Party to file, prosecute,
and/or maintain such Trubion Core Patent Right. Facet shall be responsible for [ * ] percent ([ *
]%) of the out-of-pocket costs incurred by Trubion in the course of preparing, filing, prosecuting
and maintaining the Trubion Core Patent Rights and such costs shall not be included in Development
Costs or Commercialization Costs. If Facet provides written notice to Trubion that Facet is no
longer interested in maintaining a license to a particular Trubion Core Patent Right in a
particular country, Facet will not be responsible for any portion of the costs incurred by Trubion
after the date of such notice in connection with the preparation, filing, prosecution or
maintenance of such Trubion Core Patent Right in such country, and the license granted to Facet
under such Trubion Core Patent Right in such country shall terminate upon the delivery of such
notice. If Facet assumes responsibility for any Trubion Core Patent Rights, then all costs
incurred by Facet in the course of preparing, filing, prosecuting and maintaining such Trubion Core
Patent Rights shall be borne by Facet, without reimbursement by Trubion, and such costs shall not
be included in Development Costs or Commercialization Costs. If Trubion has exercised or is deemed
to have exercised its Opt-Out Option in respect of all Products under this Agreement pursuant to
Section 7.2
, 7.3, 8.5 or 14.2(b), following the Opt-Out Effective Date, all costs incurred by
Trubion in the course of preparing, filing, prosecuting and maintaining the Trubion Core Patent
Rights shall be borne solely by Trubion. If Facet has exercised or is deemed to have exercised its
Opt-Out Option in respect of all Products under this Agreement pursuant to Section 7.2, 7.3, 8.5 or
14.2(b),

 

			
	[ * ] =	 	 Certain confidential information contained in this document, marked by brackets, has been
omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

60

 

following the Opt-Out Effective Date, all costs incurred by Trubion in the course of
preparing, filing, prosecuting and maintaining the Trubion Core Patent Rights shall be borne solely
by Trubion and Facet shall not have any rights pursuant to this Section 10.3(a) with respect to the
Trubion Core Patent Rights; provided, however, if Facet notifies Trubion in writing within [ * ]
following the Opt-Out Effective Date, with respect to one or more Trubion Core Patent Rights, that
Facet will continue to be responsible for [ * ] percent ([ * ]%) of the out-of-pocket costs
incurred by Trubion in the course of preparing, filing, prosecuting and maintaining such Trubion
Core Patent Right(s), then Facet will continue to have all rights set forth in this Section 10.3(a)
with respect to such Trubion Core Patent Right(s).

          (b) Trubion Product Patent Rights, Facet Product Patent Rights and Joint Patent Rights.

               (i) This Section 10.3(b)(i) shall apply if neither Party has exercised its Opt-Out Option, or
is deemed to have exercised its Opt-Out Option under Section 14.2(b). Decisions regarding the
preparation, filing, prosecution, and maintenance of Trubion Product Patent Rights, Facet Product
Patent Rights and Joint Patent Rights, as well as any claims within the Trubion Core Patent Rights
that claim the [ * ] or [ * ] of [ * ] or [ * ] in the [ * ] and do not claim the [ * ] or [ * ] of
[ * ] that is [ * ], in any jurisdiction in the Territory shall be made by the JPC. The JPC shall
designate a Party (the “Implementing Party”) to be responsible, using its in-house counsel or
outside patent counsel reasonably acceptable to the other Party, to implement the decisions of the
JPC regarding the preparation, filing, prosecution, and maintenance of such Patent Rights, provided
that Trubion shall be the Implementing Party for Trubion Product Patent Rights and Facet shall be
the Implementing Party for Facet Product Patent Rights. The Implementing Party shall provide the
JPC (i) a reasonable opportunity to review and comment on such prosecution efforts regarding such
Patent Rights in the Territory, (ii) a copy of each material communication received from any
patent authority in the Territory regarding such Patent Rights, and (iii) drafts of any material
filings or material responses to be made to such patent authorities a reasonable amount of time in
advance of submitting such filings or responses. Each Party shall be responsible for fifty percent
(50%) of the out-of-pocket costs incurred by the Parties in the course of preparing, filing,
prosecuting and maintaining such Patent Rights and such costs shall be included in Development
Costs if incurred prior to First Commercial Sale of a Collaboration Product or Commercialization
Costs if incurred after First Commercial Sale of a Collaboration Product.

               (ii) This Section 10.3(b)(ii) shall apply if a Party has exercised its Opt-Out Option, or is
deemed to have exercised its Opt-Out Option under Section 14.2(b), the Non-Opt-Out Party has
delivered or is deemed to have delivered a Pursuit Notice, and the Parties are not actively
Developing or Commercializing any Collaboration Products. Subject to this Section 10.3(b)(ii), the
Non-Opt-Out Party shall make and implement decisions regarding the preparation, filing,
prosecution, and maintenance of Trubion Product Patent Rights, Facet Product Patent Rights and
Joint Patent Rights, as well as any claims within the Trubion Core Patent Rights that claim the [ *
] or [ * ] of [ * ] or [ * ] in the [ * ] and do not claim the [ * ] or [ * ] of [ * ] that is [ *
], in any jurisdiction in the Territory. The Non-Opt-Out Party shall provide the Opt-Out Party:
(i) a reasonable opportunity to review and comment on such prosecution efforts regarding such
Patent Rights in the Territory; (ii) a copy of material communications from any patent authority in
the Territory regarding such Patent Rights; and (iii) drafts of any

 

			
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material filings or material responses to be made to such patent authorities a reasonable
amount of time in advance of submitting such filings or responses. If the Non-Opt-Out Party
determines to abandon, cease prosecution or not maintain any such Patent Right anywhere in the
Territory, then it shall provide the Opt-Out Party written notice of such determination at least [
* ] before any deadline for taking action to avoid abandonment (or other loss of rights) and shall
provide the Opt-Out Party with the opportunity to assume the preparation, filing, prosecution and
maintenance of such Patent Right in the affected countries of the Territory. Each Party shall be
responsible for one hundred percent (100%) of the costs it incurs in the course of preparing,
filing, prosecuting and maintaining such Patent Rights and such costs shall not be included in
Development Costs or Commercialization Costs.

               (iii) If a Party has exercised its Opt-Out Option and the Non-Opt-Out Party has delivered a
Pursuit Notice, but the Parties still are actively Developing or Commercializing one or more
Collaboration Products (i.e. Products for which neither Party has exercised its Opt-Out Option),
then (i) the provisions of Section 10.3(b)(ii) shall apply to (1) all Joint Patent Rights, Trubion
Product Patent Rights and Facet Product Patent Rights that claim the [ * ] or [ * ] of a [ * ] and
[ * ] in each case in all jurisdictions in the Territory and (2) all claims within the Trubion Core
Patent Rights that claim the [ * ] or [ * ] of [ * ] or [ * ] in the [ * ] and do not claim the [ *
] or [ * ] of [ * ], and (ii) the provisions of Section 10.3(b)(i) shall apply to (1) any other
Joint Patent Right, Trubion Product Patent Rights and Facet Product Patent Rights and (2) all
claims within the Trubion Core Patent Rights that claim the [ * ] or [ * ] of [ * ] or [ * ] in the
[ * ] and do not claim the [ * ] or [ * ] of [ * ].

          (c) Divisional Patent Application. At the request of Facet or at Trubion’s election, Trubion
shall file a continuation or divisional patent application of any Trubion Core Patent Right that
contains a claim that claims the [ * ] or [ * ] of [ * ] or [ * ] in the [ * ] and does not claim
the [ * ] or [ * ] of [ * ] that is [ * ], including U.S. Patent Application Serial Number [ * ],
if permitted by applicable Laws, shall pursue in such continuation or divisional patent
applications claims specifically directed to one or more Products and shall not pursue in such
continuation or divisional patent applications any claims specifically directed to the product
known as [ * ] or any other product that is not a Product. Such continuation or divisional patent
applications shall be deemed Trubion Product Patent Rights.

          (d) Patents Licensed from Third Parties. If either Party licenses after the Signing Date any
Patent Rights from a Third Party and such Patent Rights qualify as Trubion Patent Rights or Facet
Product Patent Rights, then each Party’s rights under this Section 10.3 with respect to such Patent
Rights shall be subject to the rights of such Third Party to prosecute, maintain and extend such
Patent Rights.

     10.4 Infringement Actions.

          (a) Notification of Litigation. In the event of the institution of any suit by a Third Party
against either Trubion or Facet or otherwise, in respect of patent infringement involving the
manufacture, use, sale, license, offer for sale, marketing, import or export of a Product within
the Field anywhere in the Territory, any Party sued or to whom notice or knowledge of such
proceeding shall arise, shall promptly notify the other Party in writing.

 

			
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          (b) Information and Settlement. Each Party shall keep the other Party informed of the status
of any patent infringement litigation or settlement thereof concerning the Products within the
Field in the Territory.

     10.5 Enforcement of Patent Rights.

          (a) Notice and Consultation. If either Facet or Trubion becomes aware of any infringement,
anywhere in the Territory, of any issued patent within the Trubion Patent Rights, Facet Product
Patent Rights, Facet Collaboration Patent Rights, or Joint Patent Rights, which infringing activity
adversely affects or is reasonably expected to adversely affect any Product, it will promptly
notify the other Party in writing to that effect and the Parties will consult with each other
regarding any actions to be taken with respect to such infringing activity.

          (b) Enforcement of Patent Rights Before Opt-Out. If neither Party has exercised or is deemed
to have exercised its Opt-Out Option, the Parties shall have the joint right, but neither Party
shall be obligated, to take action to obtain a discontinuance of infringement or bring suit against
a Third Party infringer of (1) the Trubion Patent Rights, Facet Collaboration Patent Rights, or
Facet Product Patent Rights, [ * ] such infringement [ * ] a [ * ] (as [ * ] in Section [ * ]) or
(2) the Joint Patent Rights, [ * ] of the [ * ] of such infringement. If both Parties wish to so
enforce such Patent Rights, Trubion and Facet shall be jointly responsible for, and shall bear
equally, all the costs and expenses of any such suit brought by them. Any recoveries obtained by
the Parties as a result of any proceeding against such Third Party infringer shall be allocated as
follows:

               (i) Such recovery shall first be used to [ * ] of the [ * ] for [ * ] in [ * ] such [ * ] by [
* ]; and

               (ii) The remainder of the recovery will be [ * ] the [ * ].

               If one Party elects not to participate in the infringement action and the Parties have not obtained
a discontinuance of the infringement of such Patent Rights, then the other Party shall have the
right, but not the obligation, to bring suit against such Third Party infringer of (3) the Trubion Patent Rights, Facet Collaboration Patent Rights
or Facet Product Patent Rights, [ * ] such infringement [ * ] a [ * ] (as [ * ] in Section [ * ])
or (4) the Joint Patent Rights, [ * ] of the [ * ] of such infringement; provided in each case that
the pursuing Party shall bear all of the expenses of such suit. The other Party will cooperate
with the pursuing Party in any such suit and shall have the right to consult with the pursuing
Party and to participate in and be represented by independent counsel in such litigation at its own
expense. Any recoveries obtained by the pursuing Party as a result of any such proceeding against
a Third Party infringer shall be allocated as follows:

               (iii) Such recovery shall first be used to [ * ] the [ * ] for [ * ] by such [ * ], and, then,
to [ * ] the [ * ] for [ * ] by such [ * ];

               (iv) [ * ] of the remainder of the recovery shall [ * ] the [ * ] and [ * ] shall [ * ] the [
* ];

 

			
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omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

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          (c) Enforcement of Patent Rights After Opt-Out. If a Party has exercised or is deemed to have
exercised its Opt-Out Option with respect to a Collaboration Product under this Agreement and the
Non-Opt-Out Party has delivered or is deemed to have delivered a Pursuit Notice and is pursuing the
resulting Royalty Product, the Non-Opt-Out Party shall have the first right, but not the
obligation, to take action to obtain a discontinuance of infringement or bring suit against a Third
Party infringer of (1) the Trubion Patent Rights, Facet Collaboration Patent Rights or Facet
Product Patent Rights that are licensed to the Non-Opt-Out Party, [ * ] such infringement [ * ] a [
* ] (as [ * ] in Section [ * ]) or (2) the Joint Patent Rights, [ * ] of the [ * ] of such
infringement. If the Non-Opt-Out Party does not wish to enforce such Patent Rights, it shall
timely notify the Opt-Out Party in writing and the Opt-Out Party shall have the right, but not the
obligation, to take action to obtain a discontinuance of infringement or bring suit against a Third
Party infringer of (3) the Trubion Patent Rights, Facet Collaboration Patent Rights or Facet
Product Patent Rights that are licensed to the Non-Opt-Out Party, [ * ] such infringement [ * ] a [
* ] (as [ * ] in Section [ * ]) or (4) the Joint Patent Rights, [ * ] of the [ * ] of such
infringement. The pursuing Party shall bear all of the expenses of such suit. The other Party will
cooperate with the pursuing Party in any such suit and shall have the right to consult with the
pursuing Party and to participate in and be represented by independent counsel in such litigation
at its own expense. Any recoveries obtained by the Parties as a result of any proceeding against
such Third Party infringer shall be allocated as follows:

               (i) Such recovery shall first be used to [ * ] the [ * ] for [ * ] by such [ * ], and, then,
to [ * ] the [ * ] for [ * ] by such [ * ]; and

               (ii) The remainder of the recovery will be allocated as follows:

                    a. If the [ * ] is the [ * ], the remainder shall be [ * ] as [ * ] of [ * ] by the [ * ];

                    b. If the [ * ] is the [ * ], [ * ] of the remainder of the recovery shall [ * ] and [ * ]
shall [ * ] the [ * ].

          (d) Patents Licensed from Third Parties. If either Party licenses any Patent Rights from a
Third Party and such Patent Rights qualify as Trubion Patent Rights or Facet Product Patent Rights,
then each Party’s rights under this Section 10.5 with respect to such Patent Rights shall be
subject to the rights of such Third Party to enforce such Patent Rights against infringers.

     10.6 Patent Term Extensions.

          (a) All Products. The Parties hereto shall cooperate with each other and provide reasonable
assistance to each other to obtain a patent term extension, or its equivalent anywhere in the
Territory, including under 35 U.S.C. Section 156 and its foreign counterparts, of any Trubion
Patent Right, Facet Collaboration Patent Rights or Facet Product Patent Right with respect to a
Product. Subject to Section 10.6(b), to the extent reasonably and legally required in order to
obtain any such extension in a particular country, each Party shall make available to the other a
copy of the necessary documentation to enable such other Party to use the same for the purpose of
obtaining the extension in such country.

 

			
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          (b) Collaboration Products. The JPC shall make all patent term extension decisions with
respect to a Collaboration Product. Each Party shall consult with the other Party before applying
for or obtaining any patent term extension or related extension of rights, including supplementary
protection certificates and similar rights for any Trubion Patent Rights, Facet Collaboration
Patent Rights or Facet Product Patent Rights with respect to a Collaboration Product. Neither
Party shall proceed with such an extension until the Parties have agreed to a strategy therefor
(with any disagreements on such strategy to be resolved by the JPC).

          (c) Royalty Products. The Non-Opt-Out Party shall make all elections with respect to
obtaining such patent term extension with respect to a Royalty Product for all Joint Patent Rights,
Trubion Product Patent Rights and Facet Product Patent Rights that (i) claim the [ * ] or [ * ] of
a [ * ] and [ * ] that is then [ * ] or [ * ] by the [ * ] and (ii) are licensed to the Non-Opt-Out
Party.

     10.7 Trademarks.

          (a) The JCC shall decide on a Product-by-Product basis which Party shall be responsible for
the selection, registration, maintenance and defense of all Marks for use in connection with the
sale or marketing of a Collaboration Product in the Field in the Territory. Such Party shall own
such Marks and shall grant the other Party a license with respect thereto to conduct its
obligations pursuant to the Commercialization Plan. The Parties shall share equally all Trademark
Costs, which shall be Development Costs if incurred prior to the First Commercial Sale of such
Collaboration Product and Commercialization Costs if incurred thereafter. All uses of such Marks
shall be reviewed by the JCC and shall comply with all applicable Laws and regulations (including,
without limitation, those laws and regulations particularly applying to the proper use and
designation of trademarks in the applicable countries).

          (b) The Non-Opting-Out Party shall be responsible for the selection, registration, maintenance
and defense of all Marks for use in connection with the sale or marketing of the applicable Royalty
Product in the Field in the Territory, as well as all Trademark Costs associated therewith. Such
Party shall own such Marks. All uses of such Marks shall comply with all applicable Laws and
regulations (including, without limitation, those laws and regulations particularly applying to the
proper use and designation of trademarks in the applicable countries).

          (c) Neither Party shall, without the other Party’s prior written consent, use any Mark or
Marks that include, in whole or part, any corporate name or logo of the other Party, or marks
confusingly similar thereto, in connection with such Party’s marketing or promotion of Products
under this Agreement, except as may be expressly authorized in a co-promotion agreement between the
Parties pursuant to Section 5.11 and except to the extent required to comply with applicable Laws
and regulations.

11. CONFIDENTIALITY.

     11.1 Confidentiality.

          (a) During the Term and [ * ] thereafter, each Party shall not use or reveal or disclose to
Third Parties any Confidential Information of the other Party without first obtaining

 

			
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omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

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the written consent of the other Party, except as may be otherwise provided in, or required in
order for a Party to fulfill its obligations or exercise its rights under this Agreement. This
confidentiality obligation shall not apply to such information that (i) is or becomes a matter of
public knowledge (other than by breach of this Agreement by the receiving Party), (ii) the
receiving Party can establish was already known to it or was in its possession, other than under an
obligation of confidentiality, at the time of disclosure, (iii) is disclosed to the receiving
Party, without any restrictions on further disclosure, by a Third Party having the right to do so
and that did not obtain such information from the disclosing Party, or (iv) is subsequently
independently developed or discovered by employees or agents of the receiving Party or its
Affiliates who have had no access to such Confidential Information. However, the [ * ] in [ * ]
shall [ * ] to [ * ] by [ * ] under [ * ]. The Parties shall take reasonable measures to assure
that no unauthorized use or disclosure is made by others to whom access to such information is
granted.

          (b) Each Party may disclose Confidential Information of the other Party to the extent such
disclosure is reasonably necessary in any of the following situations:

               (i) filing or prosecuting Trubion Patent Rights, Facet Product Patent Rights or Joint Patent
Rights;

               (ii) regulatory filings and other filings with Governmental Authorities (including Regulatory
Authorities), including filings with the SEC or FDA, with respect to a Product;

               (iii) prosecuting or defending litigation;

               (iv) complying with applicable Laws and regulations, including regulations promulgated by
securities exchanges, court order, and administrative subpoena or order;

               (v) disclosure to its Affiliates, employees, agents, sublicensees, and independent
contractors, to the extent necessary for the purposes of enabling the receiving Party to fulfill
its obligations under this Agreement, provided, the receiving Party shall be responsible for
breaches of the confidentiality obligations by such Affiliate, employees, agents, and independent
contractors, and provided further that, each disclosee must be bound by obligations of
confidentiality and non-use at least as equivalent in scope as those set forth in this Article 11
(except with a minimum duration of [ * ] for independent contractors) prior to any such disclosure;
and

               (vi) disclosure of the material terms of this Agreement and/or of any collaboration results or
status reports (including unblinded data from any Clinical Trials) to any bona fide potential or
actual investor, investment banker, acquirer, merger partner, sublicensee, or other potential or
actual financial or commercial partner; provided that each disclosee must be bound by obligations
of confidentiality and non-use at least as equivalent in scope as those set forth in this Article
11 (except with a minimum duration of [ * ]) prior to any such disclosure.

          (c) In the event it is necessary for a Party to disclose Confidential Information of the other
Party to comply with a court order or administrative subpoena or order, such Party must first use
its reasonable efforts to obtain an order preserving the confidentiality of the

 

			
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omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

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information and must give the other Party timely notice of the contemplated disclosure to
allow the other Party to intervene to preserve the confidentiality of the information by, for
example, seeking an appropriate protective order.

     11.2 Scientific Information. During the Term, each Party will submit to the other Party for
review and approval all proposed academic, scientific and medical publications and public
presentations relating to Products within the Field for review in connection with preservation of
patent rights and/or to determine whether any of such other Party’s Confidential Information should
be modified or deleted. Written copies of such proposed publications and presentations shall be
submitted to the non-publishing Party no later than [ * ] before submission for publication or
presentation and the non-publishing Party shall provide its comments with respect to such
publications and presentations within [ * ] of its receipt of such written copy. The publishing
Party shall delay the submission for publication or presentation for a period of up to [ * ] in the
event the non-publishing Party can demonstrate reasonable need for such delay, including without
limitation, the preparation and filing of patent applications. By mutual agreement, this period
may be further extended. In addition, upon the non-publishing Party’s request, the publishing
Party shall delete from the proposed submission any Confidential Information of the non-publishing
Party; provided, however, that with respect to a [ * ] or [ * ] by the [ * ] regarding [ * ] data
or information, the [ * ] shall [ * ] or [ * ] to the [ * ] or [ * ] of such [ * ]. Trubion and
Facet will each comply with standard academic practice regarding authorship of scientific
publications and recognition of contribution of other parties in any publications relating to
Products within the Field. Notwithstanding the rest of this Section 11.2, the Opt-Out Party may not
publish any academic, scientific or medical publications or make any public presentations regarding
the Royalty Product without the prior written consent of the Non-Opt-Out Party.

     11.3 SEC Filings. Before disclosing this Agreement or any of the terms hereof pursuant to this
Section 11.3, the Parties will consult with each other and agree upon the terms of this Agreement
to be redacted in making any such disclosure. The Parties shall separately submit confidential
treatment request to the SEC but file the same redacted Agreement in such filings. Notwithstanding
the foregoing, either Party may disclose the terms of this Agreement and any Confidential
Information related to this Agreement, including, without limitation, clinical data, to the extent
required, in the reasonable opinion of such Party’s legal counsel, to comply with applicable Laws,
including, without limitation, the rules and regulations promulgated by the United States
Securities and Exchange Commission (“SEC”), including comment letters received from the SEC related
to SEC periodic reports and other filings. .

     11.4 Public Announcements. The Parties will make a joint public announcement of this
Agreement substantially in the form of the draft press release reviewed and approved by them prior
to the signing of this Agreement. No other public announcement or other disclosure to Third
Parties concerning the terms of this Agreement shall be made, either directly or indirectly, by
either Party, except as may be legally required or as may be required for financial reporting
purposes, without first obtaining the written approval of the other Party and agreement upon the
nature and text of such announcement or disclosure.

     11.5 Non-Solicitation. Without the prior written consent of the other Party, each of Trubion
and Facet agrees that during the Term and for [ * ] thereafter, neither it nor any of its

 

			
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Affiliates will directly or indirectly solicit for purposes of hiring any person employed by
the other Party or any of its Affiliates or who was employed by the other Party or any of its
Affiliates within the then prior [ * ], or in any manner seek to induce any such person to leave
his or her employment; provided, however, that nothing in this Section 11.5 shall prohibit Facet or
Trubion, as the case may be, from hiring any employees of the other who respond to general
employment solicitations not targeted at employees of a Party or any of its Affiliates, including
general advertisements.

12. REPRESENTATIONS AND WARRANTIES.

     12.1 Representations of Trubion. Trubion represents and warrants as of the Signing Date that
(i) it is a corporation or entity duly organized and validly existing under the laws of the state
or other jurisdiction of its incorporation or formation, (ii) the execution, delivery and
performance of this Agreement by Trubion has been duly authorized by all requisite corporate action
and does not require any shareholder action or approval, (iii) it has the corporate power and
authority to execute and deliver this Agreement and to perform its obligations and to grant the
licenses granted by it to the other Party pursuant to this Agreement, and (iv) the execution,
delivery and performance by Trubion of this Agreement and its compliance with the terms and
provisions of this Agreement does not and will not conflict with or result in a breach of any of
the terms and provisions of or constitute a default under (A) any agreement or instrument binding
or affecting it or the subject matter of this Agreement; (B) the provisions of its charter or
operative documents or bylaws; or (C) any order, writ, injunction or decree of any court or
governmental authority entered against it or by which any of its property is bound except where
such conflict, breach or default would not materially impact (I) Trubion’s ability to meet its
obligations hereunder or (II) the rights granted to Facet hereunder.

     12.2 Additional Representations of Trubion. In addition, except as disclosed in Schedule
12.2, Trubion hereby represents and warrants as of the Signing Date that:

          (a) it has provided a complete and accurate list of all Third Party vendor contracts and Third
Party licenses in effect as of the Signing Date to which Trubion or a Trubion Affiliate is a Party
(i) that are reasonably necessary for the Development, Manufacture or Commercialization of TRU-016
or any other Product in the Field in the Territory in accordance with the terms of this Agreement
or (ii) pursuant to which Development, Manufacture or Commercialization services are being provided
or have been ordered as of the Signing Date with respect to TRU-016 or any other Product in the
Field in the Territory, all such contracts and licenses are in full force in accordance with their
terms except as would not reasonably be expected to, individually or in the aggregate, materially
impair the ability of the Parties to exercise the rights and perform the obligations under this
Agreement and Trubion is not in breach of any material term thereof;

          (b) except for the intellectual property licensed to Trubion pursuant the license agreements
listed in Schedule 12.2(b), it owns all right, title and interest in and to all of the
Trubion Patent Rights and Trubion Know-How; such license agreements do not and will not require
Trubion to make any royalty payments or other payments (other than services fees or other payments
not expressly identified as fees for the use of intellectual property rights) to the

 

			
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applicable Third Party licensors in consideration for the exercise of the rights licensed to
Trubion as of the Signing Date under such licenses;

          (c) it does not own and has not licensed any intellectual property that in each case would
otherwise qualify as Trubion Patent Rights or material Trubion Know-How that is reasonably
necessary for the Development, Manufacture, use, importation or Commercialization of Products in
the Field under the terms of this Agreement, but for the fact that such intellectual property is
not licensable to Facet hereunder and therefore not Controlled by Trubion (and, due solely to such
lack of Control despite owning or holding a license thereto, does not meet the definition of
Trubion Patent Rights or Trubion Know-How);

          (d) it has not received any written notice asserting or alleging that the research or
Development of any Product by or on behalf Trubion prior to the Signing Date infringed or
misappropriated the intellectual property rights of any Third Party;

          (e) to Trubion’s knowledge, the Development, Manufacture and Commercialization after the
Signing Date of TRU-016 can be carried out in the manner reasonably contemplated as of the Signing
Date without (i) infringing any Patent Rights owned or controlled by a Third Party or (ii)
misappropriating any Know-How owned or controlled by a Third Party; provided, however, that Trubion
is not making any representation or warranty pursuant to this Section 12.2(e) with respect to (1)
the [ * ] of [ * ] that were [ * ] of [ * ] from [ * ] to [ * ] (such [ * ], the “[ * ]”)] or (2)
the [ * ] of [ * ] that were [ * ] of [ * ] from [ * ] to [ * ] (such [ * ], the “[ * ]”) ;

          (f) to Trubion’s knowledge, there is no unauthorized use, infringement or misappropriation of
any of the Trubion Patent Rights or Trubion Know-How by any person;

          (g) to Trubion’s knowledge, it has not used in the Development of TRU-016 any employee, agent
or independent contractor who has been debarred by any Regulatory Authority, or is the subject of
debarment proceedings by a Regulatory Authority;

          (h) there are no actions or proceedings (including any inventorship challenges or
interferences) pending or, to the knowledge of Trubion, threatened with respect to (i) any of the
Trubion Patent Rights and Trubion Know-How or (ii) the Development or Manufacture of TRU-016;

          (i) it has made available to Facet a complete and accurate copy of any IND and other related
Regulatory Materials for TRU-016 and has not omitted any material data from such IND or Regulatory
Materials; and

          (j) no Regulatory Authority has, to Trubion’s knowledge, commenced or threatened to initiate
any action or proceeding to refuse to file, reject, not approve, or withdraw any Regulatory
Material related to the Product(s), nor has Trubion received any notice to such effect; and to
Trubion’s knowledge, Trubion is not in violation of any applicable Laws that could reasonably be
expected to form the basis for such an action; and

          (k) Trubion believes in good faith, based upon due inquiry, that the Development, Manufacture
and Commercialization after the Signing Date of TRU-016 can be

 

			
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carried out in the manner reasonably contemplated as of the Signing Date without infringing
(taking into account the provisions of 35 U.S.C. Section 271(e)) the [ * ] (as defined in Section [
* ] above) or the [ * ] (as defined in Section [ * ] above), provided that, in the case of the [ *
], due inquiry means due inquiry given the length of time since the date Trubion was made aware of
the [ * ].

     12.3 Representations of Facet. Facet represents and warrants as of the Signing Date that (i)
it is a corporation or entity duly organized and validly existing under the laws of the state or
other jurisdiction of its incorporation or formation, (ii) the execution, delivery and performance
of this Agreement by Facet has been duly authorized by all requisite corporate action and does not
require any shareholder action or approval, (iii) it has the corporate power and authority to
execute and deliver this Agreement and to perform its obligations and to grant the licenses granted
by it to the other Party pursuant to this Agreement, and (iv) the execution, delivery and
performance by Facet of this Agreement and its compliance with the terms and provisions of this
Agreement does not and will not conflict with or result in a breach of any of the terms and
provisions of or constitute a default under (A) any agreement or instrument binding or affecting it
or the subject matter of this Agreement; (B) the provisions of its charter or operative documents
or bylaws; or (C) any order, writ, injunction or decree of any court or governmental authority
entered against it or by which any of its property is bound except where such conflict, breach or
default would not materially impact (I) Facet’s ability to meet its obligations hereunder or (II)
the rights granted to Trubion hereunder.

     12.4 Disclaimer. EXCEPT AS OTHERWISE EXPRESSLY SET FORTH IN SECTIONS 12.1, 12.2 AND 12.3, THE
PARTIES MAKE NO REPRESENTATIONS AND EXTEND NO WARRANTIES OF ANY KIND, EITHER EXPRESS OR IMPLIED,
AND PARTICULARLY THAT PRODUCTS WILL BE SUCCESSFULLY DEVELOPED HEREUNDER, AND IF PRODUCTS ARE
DEVELOPED, WITH RESPECT TO SUCH PRODUCTS, THE PARTIES DISCLAIM ALL IMPLIED WARRANTIES OF TITLE,
NON-INFRINGEMENT, MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE.

     12.5 Mutual Covenant. Each Party covenants to the other Party that it shall at all times
comply in all material respects with all applicable Laws relating to its activities under this
Agreement.

13. LIABILITY AND INDEMNIFICATION.

     13.1 Limitation on Liability. Except for breaches of Section 8.5 or Article 11, neither Party
shall be liable to the other Party under this Agreement for any indirect, incidental, punitive,
exemplary, special or consequential damages of any kind whatsoever sustained as a result of a
breach of this Agreement; provided, however, that this limitation will not reduce or affect the
Parties’ obligations in respect of Third Party claims under Section 13.2 or Section 13.3.

     13.2 Mutual Indemnification. Each Party shall defend, indemnify and hold harmless the other
Party and its Affiliates and their officers, directors, shareholders, employees, agents,
representatives, successors and assigns from and against all Third Party claims, complaints, recall
obligations and liabilities, or lawsuits for damages (collectively referred to as “Claims”) arising
out of (i) any negligent act or omission, or willful wrongdoing by the indemnifying Party,

 

			
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its Affiliate or sublicensees in the performance of this Agreement, (ii) the failure by the
indemnifying Party, its Affiliate or sublicensees to comply with any applicable Law or governmental
requirement, and/or (iii) any breach of any representation or warranty of the indemnifying Party
contained in this Agreement. The indemnifying Party shall not be obligated under this Section 13.2
to the extent that the Claim was the result of the non-performance, negligence or willful
misconduct of the indemnified Party or anyone acting on behalf of the indemnified Party, including
its Affiliates and sublicensees, and its and their officers, directors, shareholders, employees,
agents, representatives, successors and assigns.

     13.3 Indemnification After Opt-Out. In addition to its obligations under Section 13.2, if a
Party has exercised or is deemed to have exercised its Opt-Out Option with respect to a Product and
the Non-Opt-Out Party has delivered or is deemed to have delivered a Pursuit Notice with respect
thereto, the Non-Opt-Out Party shall defend, indemnify and hold harmless the Opt-Out Party and its
Affiliates and their officers, directors, shareholders, employees, agents, representatives,
successors and assigns from and against all Claims arising out of the Development, manufacture,
use, handling, storage, promotion, use, sale, license, offer for sale, marketing, import or export
of such Royalty Product (other than to the extent the Opt-Out Party is responsible for the Claim
under Section 13.2) on or after the Opt-Out Effective Date. The Non-Opt-Out Party shall not be
obligated under this Section 13.3 to the extent that the Claim was the result of the
nonperformance, negligence or willful misconduct of the Opt-Out Party or anyone acting on behalf of
the Opt-Out Party, including its Affiliates or sublicensees, and their officers, directors,
shareholders, employees, agents, representatives, successors and assigns.

     13.4 Limitations on Indemnification. The obligations to indemnify, defend, and hold harmless
set forth in Sections 13.2 and 13.3 shall be contingent upon the Party seeking indemnification (the
”Indemnitee”): (i) notifying the indemnifying Party of a claim, demand or suit within ten (10) days
of receipt of same; provided, however, that Indemnitee’s failure or delay in providing such notice
shall not relieve the indemnifying Party of its indemnification obligation except to the extent the
indemnifying Party is prejudiced thereby; (ii) allowing the indemnifying Party and/or its insurers
the right to assume direction and control of the defense of any such claim, demand or suit; (iii)
using its [ * ] to cooperate with the indemnifying Party and/or its insurers, at the indemnifying
Party’s expense, in the defense of such claim, demand or suit; and (iv) agreeing not to settle or
compromise any claim, demand or suit without prior written authorization of the indemnifying Party.
The Indemnitee shall have the right to participate in the defense of any such claim, demand or
suit referred to in this Section 13.4 utilizing attorneys of its choice, at its own expense,
provided, however, that the indemnifying Party shall have full authority and control to handle any
such claim, demand or suit.

     13.5 Other Third Party Claims. In the event of the institution after the Signing Date of any
suit by a Third Party against either Trubion or Facet, in respect of the Development, Manufacture,
use, handling, storage, promotion, use, sale, license, offer for sale, marketing, import or export
of a Collaboration Product within the Field anywhere in the Territory for such activities during
the Term for which neither Party is responsible under Section 13.2 or Section 13.3 the Parties
shall cooperate and jointly control the defense and settlement of the suit and all out-of-pocket
litigation expenses incurred by the Parties in the defense or settlement of the suit as well as all
damages awarded against a Party or agreed to by the Parties in a settlement shall be considered
Development Costs, if incurred prior to the First Commercial Sale of such

 

			
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Collaboration Product, or Commercialization Costs, if incurred after the First Commercial Sale
of such Collaboration Product, or [ * ] under Section [ * ] if [ * ] the [ * ] or [ * ] by a [ * ]
of the [ * ] for the applicable [ * ].

     13.6 Insurance. During the Term and for a period of [ * ] after the Term, or, in the case of
a Party that has exercised or is deemed to have exercised its Opt-Out Option in respect of all
Products under this Agreement until [ * ] after the final Opt-Out Effective Date, each Party shall
obtain and/or maintain, respectively, at its sole cost and expense, product liability insurance in
amounts, respectively, which are reasonable and customary in the pharmaceutical industry for
companies of comparable size and activities at the respective place of business of each Party;
provided that such amounts shall not be less than [ * ] Dollars ($[ * ]) before the first dosing of
the first patient in the initial Phase III Clinical Study (or the transition to the pivotal phase
of a Phase II/III Clinical Study) of a Product and shall not be less than [ * ] Dollars ($[ * ])
thereafter. Such product liability insurance shall insure against all liability, including
personal injury, physical injury, or property damage arising out of the manufacture, sale,
distribution, or marketing of the Collaboration Products and the Royalty Products (solely in the
event that the policy holder is the Non-Opt-Out Party with respect thereto) in the Territory. Each
Party shall provide written proof of the existence of such insurance to the other Party upon
request.

14. TERM AND TERMINATION.

     14.1 Term. This Agreement shall become effective on the Signing Date and, unless earlier
terminated pursuant to this Article 14, shall expire on a Product-by-Product and country-by-country
basis (a) in respect of Royalty Products, upon expiration of the Royalty Period for the Royalty
Product in the country and (b) in respect of Collaboration Products, at such time as Facet and
Trubion and their Affiliates and permitted sublicensees have all stopped selling the Collaboration
Product in the country and the Commercialization Plan does not contemplate future sales of the
Collaboration Product in the country (the “Term”). If the Term or license has not been earlier
terminated, upon the expiration of the Term on a Product-by-Product and country-by-country basis,
the licenses granted to each Party hereunder shall, with respect to such Product(s) and
country(ies), upon and after such expiration, become nonexclusive, royalty-free, paid-up and
irrevocable.

     14.2 Termination by Either Party for Breach.

          (a) Breach. Subject to Section 14.2(c), each Party shall have the right to terminate this
Agreement upon written notice to the other Party if the other Party materially breaches its
obligations under this Agreement and, after receiving written notice from the non-breaching Party
identifying such material breach in reasonable detail, fails to cure such material breach within [
* ] from the date of such notice (or within [ * ] from the date of such notice in the event such
material breach is solely based upon the breaching Party’s failure to pay any amounts due
hereunder); provided that if such material breach is not reasonably subject to cure within the [ *
] period from notice, then the breaching Party shall have an additional [ * ] to effect such cure
if it is undertaking Diligent Efforts to cure such breach and shall have provided a written plan
reasonably acceptable to the non-breaching Party to cure such breach within such additional period.
Notwithstanding anything to the contrary in this Agreement, the breaching Party shall not have the
right to exercise its Opt-Out Option pursuant to Section 7.2 and Facet shall not have

 

			
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the right to terminate the Agreement under Section 14.3 during the period between its receipt
of the notice of a material breach and its cure of such material breach or the resolution of any
dispute with respect thereto pursuant to Section 14.2(c); provided that if such dispute is resolved
in the favor of such alleged breaching Party, such Party shall be entitled to exercise its Opt-Out
Option pursuant to Section 7.2 or, in the case of Facet, its right to terminate the Agreement under
Section 14.3 within [ * ] of such resolution if it was deprived of the ability to exercise its
Opt-Out Option on account of this sentence.

          (b) Continuation. If the non-breaching Party has the right to terminate this Agreement under
Section 14.2(a), then, instead of terminating this Agreement, the non-breaching Party may elect to
continue this Agreement by notice to the breaching Party, provided, however, if the non-breaching
Party elects to continue this Agreement, upon written notice of continuation from the non-breaching
Party, then the breaching Party shall be deemed to have exercised its Opt-Out Option and the notice
pursuant to this Section 14.2(b) shall be deemed an “Opt-Out Notice” and a “Pursuit Notice” with
respect to all Products under this Agreement regardless of whether such breach related to any
particular Product and the provisions of Section 7.5 shall apply with respect to all Products under
this Agreement and the breaching Party shall bear [ * ] percent ([ * ]%) of the reasonable expenses
incurred by the non-breaching Party in the course of performing its transfer obligations pursuant
to Sections 7.5(b)(iii), 7.5(b)(iv), 7.5(vi)(2) and 7.5(vii). The preceding sentence shall not in
any event limit in any manner the non-breaching Party’s other remedies for an uncured material
breach of this Agreement.

          (c) Disputed Breach. If the alleged breaching Party disputes in good faith the existence or
materiality of a breach specified in a notice provided by the other Party in accordance with
Section 14.2(a), and such alleged breaching Party provides the other Party notice of such dispute
and its intention to seek arbitration or judgment by a court pursuant to Article 15 within such [ *
] period (or [ * ] period for failure to make any payment), then the non-breaching Party shall not
have the right to terminate this Agreement under Section 14.2(a) unless and until an arbitrator or
court, in accordance with Article 15, has determined that the alleged breaching Party has
materially breached this Agreement and that such Party fails to cure such breach within [ * ]
following such decision of such arbitrator or court (except to the extent such breach involves the
failure to make a payment when due, which breach must be cured within [ * ] following such decision
of such arbitrator or court). It is understood and agreed that during the pendency of such dispute,
all of the terms and conditions of this Agreement shall remain in effect and the Parties shall
continue to perform all of their respective obligations hereunder.

     14.3 Termination by Facet at Will. Facet shall have the right to terminate this Agreement in
its entirety upon [ * ] prior written notice to Trubion, provided that, within eighteen (18) months
after the Signing Date, such notice shall only be effective if accompanied by the payment of a
termination fee equal to Ten Million Dollars ($10,000,000.00). Notwithstanding anything to the
contrary in this Agreement, Facet shall have no right to terminate this Agreement pursuant to the
preceding sentence after Facet has been deemed to have exercised its Opt-Out Option on account of
an uncured breach pursuant to Section 14.2(b).

     14.4 Effects of Termination by Facet at Will. Upon termination of this Agreement by Facet
under Section 14.3, the following shall apply (in addition to any other rights and obligations
under this Agreement with respect to such termination):

 

			
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          (a) Licenses. The licenses granted in Article 8 shall terminate. Notwithstanding the
foregoing, Facet hereby grants to Trubion, effective only upon such termination, a [ * ] license,
with [ * ] to [ * ] of [ * ], under the [ * ] to Develop, make, have made, use, import, export,
offer for sale, sell and Commercialize any Products that are in active clinical development or are
Commercialized as of the date of termination for the Field in the Territory, provided that if [ * ]
in [ * ] within [ * ] after the [ * ] of [ * ], [ * ] will [ * ] to [ * ], with [ * ] to [ * ] of [
* ], under the [ * ] to [ * ] and [ * ] any [ * ] that are [ * ] or are [ * ] as of the [ * ] of [
* ] for the [ * ] in the [ * ], upon [ * ] to [ * ] to be [ * ] in [ * ] by the [ * ], provided
that if the [ * ] are [ * ] to [ * ] the [ * ] for such [ * ] within [ * ], the [ * ] for such [ *
] shall be [ * ] by [ * ] pursuant to Section [15.3(c)]. In all cases where any element of the
Facet Applied Technology is licensed to Facet by a Third Party, as a condition precedent for a
license to be granted to Trubion pursuant to this Section 14.4(a), Trubion shall be required to
agree in writing within [ * ] of the effective date of termination to pay any payments, including
royalties on sales by Trubion or its permitted sublicensees, that accrue and become payable to such
Third Party licensor after the effective date of the license to Trubion. Facet will not be
obligated to maintain any Third Party license agreement in effect unless Trubion timely exercises
its rights as provided in the foregoing sentence or to grant sublicenses under this Section
14.4(a), if Facet is prohibited from granting such sublicenses under its agreement(s) with its
licensor(s), but shall be required to use Diligent Efforts to obtain permission to grant such a
sublicense from any such licensor(s).

          (b) Marks. Facet shall, as promptly as commercially practicable, assign to Trubion all of
Facet’s right, title and interest in and to the Marks used or to be used with the Products
(excluding any such Marks that include, in whole or part, any corporate name or logo of Facet or
its Affiliates or permitted sublicensees), including any goodwill associated therewith. For the
avoidance of doubt, only those Marks which have been (i) identified prior to the effective date of
termination of this Agreement as the single designated lead candidate Mark for a non-commercialized
Product, or (ii) actually used in connection with a Commercialized Product, shall be assigned.
Trubion shall be responsible for recording such assignment in the Territory with the appropriate
Governmental Authority and will bear all costs associated with such assignment and recordation.
Facet shall cooperate in facilitating such assignment and recordation by timely executing all
necessary documents provided to it by Trubion.

          (c) Regulatory Materials. Facet shall transfer and assign to Trubion in the form and format in
which such materials are maintained by Facet in the ordinary course of business, all Regulatory
Materials for Products in the Territory that are Controlled by Facet or its Affiliates or permitted
sublicensees.

          (d) Transition Assistance. Facet shall, [ * ], provide Transition Assistance for the purpose
of transferring or transitioning to Trubion, (i) in the form and format in which such Facet Applied
Know-How is maintained by Facet in the ordinary course of business, all Facet Applied Know-How not
already in Trubion’s possession, and (ii) at Trubion’s request, all then-existing Third Party
agreements relating solely to Products hereunder and that Facet is able, using Diligent Efforts to,
assign to Trubion, in each case, to the extent reasonably necessary for Trubion to continue
researching, Developing, Manufacturing, or Commercializing Products, provided, however, that Facet
shall be required to assign any such agreement solely to the extent assignment is permitted by such
agreement, and Facet is not required to pay any consideration or commence litigation in order to
effect an assignment of any such agreement to Trubion.

 

			
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          (e) Remaining Inventories. Trubion shall have the right to purchase from Facet [ * ] (less any
portion of the cost previously shared by Trubion as a Development Cost or Commercialization Cost)
any or all of the inventory of Bulk API and/or Products held by or for Facet or its Affiliates as
of the effective date of termination pursuant to the terms of this Agreement or the Commercial
Supply Agreement, as applicable. Trubion shall notify Facet within [ * ] after the effective date
of termination whether Trubion elects to exercise such right.

     14.5 Effect of Termination by Trubion for Uncured Breach. Upon termination of this Agreement
by Trubion under Section 14.2(a), the licenses granted under Article 8 shall terminate.
Notwithstanding the foregoing, Facet hereby grants Trubion, effective only upon such termination, a
[ * ] license, with [ * ] to [ * ] of [ * ], under [ * ], to Develop, make, have made, use, import,
export, offer for sale, sell and Commercialize any Products that are [ * ] or are [ * ] as of the [
* ] of [ * ] for the [ * ] in the [ * ]. In addition, Facet shall comply with Section 14.4(c).

     14.6 Other Remedies. Termination or expiration of this Agreement for any reason shall not
release either Party from any liability or obligation that already has accrued prior to such
expiration or termination, nor affect the survival of any provision of this Agreement to the extent
it is expressly stated to survive such termination. Termination or expiration of this Agreement for
any reason shall not constitute a waiver or release of, or otherwise be deemed to prejudice or
adversely affect, any rights, remedies or claims, whether for damages or otherwise, that a Party
may have hereunder or that may arise out of or in connection with such termination or expiration.

     14.7 Rights in Bankruptcy. All rights and licenses granted under or pursuant to this
Agreement by Trubion and Facet are, and shall otherwise be deemed to be, for purposes of Section
365(n) of the United States Bankruptcy Code, licenses of rights to “intellectual property” as
defined under Section 101 of the United States Bankruptcy Code. The Parties agree that each Party,
as licensee of certain rights under this Agreement, shall retain and may fully exercise all of its
rights and elections under the United States Bankruptcy Code. The Parties further agree that, in
the event of the commencement of a bankruptcy proceeding by or against a Party (such Party, the
”Bankrupt Party”) under the United States Bankruptcy Code, (a) the other Party shall be entitled to
a complete duplicate of (or complete access to, as appropriate) any intellectual property licensed
to such other Party and all embodiments of such intellectual property, which, if not already in
such other Party’s possession, shall be promptly delivered to it (x) upon any such commencement of
a bankruptcy proceeding upon such other Party’s written request therefor, unless the Bankrupt Party
elects to continue to perform all of its obligations under this Agreement or (y) if not delivered
under clause (x), following the rejection of this Agreement by the Bankrupt Party upon written
request therefor by the other Party and (b) the Bankrupt Party shall not interfere with the other
Party’s rights to intellectual property and all embodiments of intellectual property, and shall
assist and not interfere with the other Party in obtaining intellectual property and all
embodiments of intellectual property from another entity. The “embodiments” of intellectual
property includes all tangible, intangible, electronic or other embodiments of rights and licenses
hereunder, including all compounds and products embodying intellectual property, Products, filings
with Regulatory Authorities and related rights and Trubion Know-How in the case that Trubion is the
Bankrupt Party and Facet Applied Know-How in the case Facet is the Bankrupt Party.

 

			
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     14.8 Continuing Rights and Obligations. Termination or expiration of this Agreement shall not
affect rights or obligations of the Parties under this Agreement that have accrued prior to the
date of termination or expiration of this Agreement. Notwithstanding anything to the contrary, the
following provisions shall survive and apply after expiration or termination of this Agreement:
Sections [ * ], and [ * ], Article [ * ] (other than Section [ * ]), Article [ * ] (other than
Section [ * ]), Article [ * ], Sections [ * ] (only with respect to the [ * ]), [ * ], and [ * ],
Article [ * ], and Article [ * ]. In addition, the other applicable provisions of Article 9 shall
survive to the extent required to make final reimbursements, reconciliations or other payments with
respect to Product Profits, Net Sales and costs and expenses incurred or accrued prior to the date
of termination or expiration. Furthermore, any other provision required to interpret or to enforce
the Parties’ remaining rights and obligations under this Agreement shall also survive, but only to
the extent required for the full observation and performance of this Agreement. All provisions not
surviving in accordance with the foregoing shall terminate upon expiration or termination of this
Agreement and be of no further force and effect.

15. DISPUTE RESOLUTION; LIABILITY.

     15.1 General. Any controversy, claim or dispute arising out of or relating to this Agreement
shall be settled, if possible, through good faith negotiations between the Parties. If, however,
the Parties are unable to settle such dispute after good faith negotiations, the matter shall be
referred to the Executive Officers to be resolved by negotiation in good faith as soon as is
practicable but in no event later than [ * ] after referral.

     15.2 Failure of Executive Officers to Resolve Dispute. If the Executive Officers are unable
to settle the dispute after good faith negotiation in the manner set forth above or in Section 2.7,
the matter (a) shall be resolved in accordance with Section 15.3, and (b) either Party may seek
injunctive or other equitable relief in any court in any jurisdiction where appropriate.

     15.3 Arbitration. Matters under Section 15.2 which are to be resolved through binding
arbitration shall be settled by traditional arbitration or, for matters specifically identified in
Section 2.7(c)(a), baseball arbitration, in accordance with the Commercial Arbitration Rules of the
American Arbitration Association (“AAA”) then in effect, except to the extent such rules are
inconsistent with this Section 15.3. The proceedings and decisions of the arbitrators shall be
confidential, final and binding on the Parties, and judgment upon the award of such arbitrator(s)
may be entered in any court having jurisdiction thereof.

          (a) The arbitration shall take place in [ * ] (if [ * ]) or [ * ] (if [ * ]).

          (b) Traditional arbitration shall be conducted by an arbitration panel consisting of three (3)
independent arbitrators, and the award or decision shall be rendered by a majority of the members
of the arbitration panel. Each arbitrator shall have not less than fifteen (15) years of
experience in the biotechnology or pharmaceutical industry and subject matter expertise with
respect to the matter subject to arbitration. Each Party shall appoint one arbitrator, and the
third arbitrator shall be selected jointly by the two arbitrators appointed by the Parties, unless
the Parties otherwise agree as to the identity of the third arbitrator. If the two arbitrators
appointed by the Parties are unable to agree upon the third arbitrator within [ * ] of any request
for arbitration, such arbitrator shall be selected by the AAA. Any arbitrator chosen hereunder

 

			
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shall have educational training and industry experience sufficient to demonstrate a reasonable
level of scientific, financial, medical and industry knowledge relevant to the particular dispute.
The written decision of the arbitrators shall state the panel’s findings of material facts and the
grounds for its conclusions and shall be final, conclusive and binding on the Parties and
enforceable by any court of competent jurisdiction.

          (c) Baseball Arbitration will be conducted by one (1) arbitrator who shall be reasonably
acceptable to the Parties and who shall be appointed in accordance with AAA rules. If the Parties
are unable to select an arbitrator within [ * ] of the notice that initiated the baseball
arbitration, then the arbitrator shall be appointed in accordance with AAA rules. Any arbitrator
chosen hereunder shall have educational training and industry experience sufficient to demonstrate
a reasonable level of scientific, financial, medical and industry knowledge relevant to the
particular dispute. Within [ * ] after the selection of the arbitrator, each Party shall submit to
the arbitrator and the other Party a proposed resolution of the dispute that is the subject of the
arbitration, together with any relevant evidence in support thereof (the “Proposals”). Within [ *
] after the delivery of the last Proposal to the arbitrator, each Party may submit a written
rebuttal of the other Party’s Proposal and may also amend and re-submit its original Proposal. The
Parties and the arbitrator shall meet within [ * ] after the Parties have submitted their final
Proposals (and rebuttals, if any), at which time each Party shall have [ * ] to argue in support of
its Proposal. The Parties shall not have the right to call any witnesses in support of their
arguments, nor compel any production of documents or take any discovery from the other Party in
preparation for the meeting. Within [ * ] after such meeting, the arbitrator shall select one of
the final Proposals so submitted by one of the Parties as the resolution of the dispute, but may
not alter the terms of either final Proposal and may not resolve the dispute in a manner other than
by selection of one of the submitted final Proposals. If a Party fails to submit a Proposal within
the initial [ * ] time frame set forth in the fourth sentence of this Section 15.3(c), the
arbitrator shall select the Proposal of the other Party as the resolution of the dispute. Any time
period set forth in this Section 15.3(c) may be extended by mutual agreement of the Parties.

          (d) Each Party shall bear its own costs and expenses (including legal fees and expenses)
relating to the arbitration proceeding, except that the fees of the arbitrator(s) and other related
costs of the arbitration shall be shared equally by the Parties, unless the arbitrator(s)
determine(s) that a Party has incurred unreasonable expenses due to vexatious or bad faith
positions taken by the other Party, in which event the arbitrator(s) may make an award of all or
any portion of such expenses so incurred.

          (e) The arbitrator(s) shall be required to render their decision in writing and to comply
with, and their award shall be limited by, any express provisions of this Agreement relating to
damages or the limitation thereof. No arbitrator shall have the power to award punitive damages
under this Agreement regardless of whether any such damages are contained in a Proposal, and such
award is expressly prohibited.

     15.4 Patent and Trademark Disputes. Notwithstanding Section 15.2, any dispute, controversy or
claim relating to the scope, validity, enforceability or infringement of any Patent Rights or
trademark rights covering the manufacture, use, importation, offer for sale or sale of Products
shall be submitted to a court of competent jurisdiction in the country in which such Patent Rights
or trademark rights were granted or arose.

 

			
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16. MISCELLANEOUS.

     16.1 Assignment. Except as provided in subsections (a) and (b) below, neither this Agreement
nor any interest hereunder shall be assignable by either Party, without the prior written consent
of the other Party, which consent shall not be unreasonably withheld or delayed. This Agreement
shall be binding upon the successors and permitted assigns of the Parties, and the name of a Party
appearing herein shall be deemed to include the names of such Party’s successors and permitted
assigns to the extent necessary to carry out the intent of this Agreement. In addition to the
foregoing, each Party may assign its right, in whole or part, to receive payments under this
Agreement. Any assignment not in accordance with this Section 16.1 shall be void. Notwithstanding
anything to the contrary in this Agreement, in the event that a Party undergoes an acquisition by a
Third Party, no intellectual property rights of the Third Party assignee, acquiror or successor of
such Party or any Affiliate of such Third Party shall be included in the subject matter licensed
hereunder, to the extent that such intellectual property rights were held by the Third Party prior
to the acquisition, or are created outside of any activities under this Agreement by personnel who
were not employees of the acquired Party at the time of the acquisition. Notwithstanding anything
to the contrary in this Agreement, in the event that a Party makes an assignment pursuant to
subsection (b) below to a Third Party, no intellectual property rights of the Third Party assignee
or any Affiliate of such Third Party shall be included in the subject matter licensed hereunder, to
the extent that such intellectual property rights were held by the Third Party prior to the
assignment, or are created outside of any activities under this Agreement by personnel who were not
employees of the assigning Party at the time of the assignment.

          (a) Each Party may assign all of its rights and delegate all of its obligations under this
Agreement without the other Party’s consent to an Affiliate or to a successor to substantially all
of the business of such Party to which this Agreement relates, whether in merger, sale of stock,
sale of assets or other transaction.

          (b) Each Party may assign all of its rights and delegate all of its obligations under this
Agreement without the other Party’s consent to a Third Party who is not a successor to such Party
as described in Section 16.1(a), if such Third Party is not a CD37 Competitor, provided that: (i)
before commencing negotiations with such a Third Party for such an assignment, the assigning Party
shall notify the other Party, and the Parties shall have [ * ] to negotiate in good faith a
non-binding term sheet setting forth the principal terms and conditions under which the assigning
Party would assign such rights and delegate such obligations to the other Party. If the Parties
agree on such non-binding term sheet within the [ * ]-period, then the Parties shall have an
additional time period, not to exceed [ * ] from the receipt of the notice from the assigning
Party, to enter into a definitive agreement based on the terms of the non-binding term sheet.
Notwithstanding anything to the contrary above, the assigning Party shall at all times be free to
engage in concurrent negotiations with one or more Third Parties but shall not conclude an
assignment with a Third Party during the [ * ] period described above during which the Parties are
negotiating the term sheet and/or during the [ * ] period described above during which the Parties
are negotiating the definitive agreement; and (iii) the assigning Party shall also assign or
otherwise grant a license to such Third Party assignee to all of its Patent Rights and Know-How
under its Control that are specific to the Products, and grant to such Third Party assignee all
other rights and deliver to such Third Party assignee all information and materials in

 

			
	[ * ] =	 	 Certain confidential information contained in this document, marked by brackets, has been
omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

78

 

each case that is reasonably necessary for such Third Party assignee to perform the assigning
Party’s obligations under this Agreement.

     16.2 Further Actions. Each Party agrees to execute, acknowledge and deliver such further
instruments, and to do all such other acts, as may be necessary or appropriate in order to carry
out the purposes and intent of this Agreement.

     16.3 Government Approvals. Trubion and Facet will cooperate and use respectively Diligent
Efforts to make all registrations, filings and applications, to give all notices and to obtain as
soon as practicable all governmental or other consents, transfers, approvals, orders,
qualifications authorizations, permits and waivers, if any, and to do all other things necessary or
desirable for the consummation of the transactions as contemplated hereby.

     16.4 Force Majeure. Neither Party shall be liable to the other for delay or failure in the
performance of the obligations on its part contained in this Agreement if and to the extent that
such failure or delay is due to circumstances beyond its control which it could not have avoided by
the exercise of reasonable diligence. It shall notify the other Party promptly should such
circumstances arise, giving an indication of the likely extent and duration thereof, and shall use
all Diligent Efforts to resume performance of its obligations as soon as practicable; provided,
however, that neither Party shall be required to settle any labor dispute or disturbance.

     16.5 Correspondence and Notices.

          (a) Ordinary Notices. Correspondence, reports, documentation, and any other communication in
writing between the Parties in the course of ordinary implementation of this Agreement shall be
delivered by hand, or sent by facsimile transmission, email or airmail to the employee or
representative of the other Party who is designated by such other Party to receive such written
communication.

          (b) Extraordinary Notices. Extraordinary notices and other communications hereunder
(including without limitation, any notice of force majeure, breach, termination, change of address,
etc.) shall be in writing and shall be deemed given if delivered personally or by facsimile
transmission (receipt verified), mailed by registered or certified mail (return receipt requested),
postage prepaid, or sent by nationally recognized express courier service, to the Parties at the
following addresses (or at such other address for a Party as shall be specified by like notice;
provided, however, that notices of a change of address shall be effective only upon receipt
thereof):

	 	 	 	 	 	 	 
	 	 	All correspondence to Facet shall be addressed as follows:
	 
	 	 	 	 	 	 
	 

	 	 	 	Facet Biotech Corporation
	 	 
	 

	 	 	 	1500 Seaport Blvd.
	 	 
	 

	 	 	 	Redwood City, CA 94063
	 	 
	 

	 	 	 	Attn: Chief Executive Officer
	 	 
	 

	 	 	 	Fax: (650) 454-2000	 	 

 

		
	[ * ] =  	Certain confidential information contained in this document, marked by brackets, has
been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule
24b-2 of the Securities Exchange Act of 1934, as amended.

79

 

	 	 	 	 	 	 	 
	 	 	with a copy to:
	 
	 	 	 	 	 	 
	 

	 	 	 	Facet Biotech Corporation
	 	 
	 

	 	 	 	1500 Seaport Blvd.
	 	 
	 

	 	 	 	Redwood City, CA 94063
	 	 
	 

	 	 	 	Attn: General Counsel
	 	 
	 

	 	 	 	Fax: (650) 454-2000	 	 
	 
	 	 	 	 	 	 
	 	 	and a copy to:
	 
	 	 	 	 	 	 
	 

	 	 	 	Cooley Godward Kronish LLP
	 	 
	 

	 	 	 	Five Palo Alto Square
	 	 
	 

	 	 	 	3000 El Camino Real
	 	 
	 

	 	 	 	Palo Alto, CA 94306-2155
	 	 
	 

	 	 	 	Attn: Glen Sato
	 	 
	 

	 	 	 	Fax: (650) 849-7400	 	 
	 
	 	 	 	 	 	 
	 	 	All correspondence to Trubion shall be addressed as follows:
	 
	 	 	 	 	 	 
	 

	 	 	 	Trubion Pharmaceuticals, Inc.
	 	 
	 

	 	 	 	2401 4th Avenue
	 	 
	 

	 	 	 	Suite 1050
	 	 
	 

	 	 	 	Seattle, Washington 98121
	 	 
	 

	 	 	 	Attn: President & CEO
	 	 
	 

	 	 	 	Fax: (206) 838-0503	 	 
	 
	 	 	 	 	 	 
	 	 	with a copy to:
	 
	 	 	 	 	 	 
	 

	 	 	 	Trubion Pharmaceuticals, Inc.
	 	 
	 

	 	 	 	2401 4th Avenue
	 	 
	 

	 	 	 	Suite 1050
	 	 
	 

	 	 	 	Seattle, Washington 98121
	 	 
	 

	 	 	 	Attn: General Counsel
	 	 
	 

	 	 	 	Fax: (206) 838-0503	 	 
	 
	 	 	 	 	 	 
	 	 	and a copy to: Fenwick & West LLP
	 
	 	 	 	 	 	 
	 

	 	 	 	1191 Second Avenue
	 	 
	 

	 	 	 	10th Floor
	 	 
	 

	 	 	 	Seattle, WA 98101
	 	 
	 

	 	 	 	Attn: Alan C. Smith
	 	 
	 

	 	 	 	Fax: (206) 389-4511	 	 

     16.6 Representation by Legal Counsel. Each Party hereto represents that it has been
represented by legal counsel in connection with this Agreement and acknowledges that it has
participated in the drafting of this Agreement. In interpreting and applying the terms and
provisions of this Agreement, the Parties agree that no presumption shall exist or be implied
against the Party which drafted such terms and provisions.

 

			
	[ * ]	 	 = Certain confidential information contained in this document, marked by brackets, has
been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule
24b-2 of the Securities Exchange Act of 1934, as amended.

80

 

     16.7 Amendment. No amendment, modification or supplement of any provision of this
Agreement shall be valid or effective unless made in writing and signed by a duly authorized
officer of each Party.

     16.8 Waiver. Except as expressly limited by the terms of this Agreement, no failure on the
part of any Person to exercise any power, right, privilege or remedy under this Agreement, and no
delay on the part of any Person in exercising any power, right, privilege or remedy under this
Agreement, shall operate as a waiver of such power, right, privilege or remedy; and no single or
partial exercise of any such power, right privilege or remedy shall preclude any other or further
exercise thereof or of any other power, right, privilege or remedy. No provision of this Agreement
shall be waived by any act, omission or knowledge of a Party or its agents or employees except by
an instrument in writing expressly waiving such provision and signed by a duly authorized officer
of the waiving Party. The waiver by either of the Parties of any breach of any provision of this
Agreement by the other Party shall not be construed to be a waiver of any succeeding breach of such
provision or a waiver of the provision itself.

     16.9 Severability. If any clause or portion thereof in this Agreement is for any reason held
to be invalid, illegal or unenforceable, the same shall not affect any other portion of this
Agreement, as it is the intent of the Parties that this Agreement shall be construed in such
fashion as to maintain its existence, validity and enforceability to the greatest extent possible.
In any such event, this Agreement shall be construed as if such clause of portion thereof had never
been contained in this Agreement, and there shall be deemed substituted therefor such provision as
will most nearly carry out the intent of the Parties as expressed in this Agreement to the fullest
extent permitted by applicable Law.

     16.10 Construction

          (a) The descriptive headings of this Agreement are for convenience only, and shall be of no
force or effect in construing or interpreting any of the provisions of this Agreement.

          (b) Any rule of construction to the effect that ambiguities are to be resolved against the
drafting party shall not be applied in the construction or interpretation of this Agreement.

          (c) Except as otherwise indicated, all references in this Agreement to “Articles”, “Sections,”
“Exhibits” and “Schedules” are intended to refer to Articles and Sections of this Agreement, and
Exhibits and Schedules to this Agreement.

     16.11 Governing Law. This Agreement shall be governed by and interpreted in accordance with the
substantive laws of the State of California, without regard to conflict of law principles thereof.

     16.12 Entire Agreement of the Parties. This Agreement constitutes and contains the complete,
final and exclusive understanding and agreement of the Parties and cancels and supersedes any and
all prior negotiations, correspondence, understandings and agreements, whether oral or written,
among the Parties respecting the subject matter of this Agreement and thereof. For clarity, the
rights and obligations of the Parties on and after the Signing Date with

 

			
	[ * ]	 	 = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

81

 

respect to disclosures
made under the Non-Disclosure Agreement that relate to the subject matter of this Agreement shall
be solely as set forth in this Agreement but the Non-Disclosure Agreement shall remain in full
force and effect with respect to all other disclosures made thereunder.

     16.13 Independent Contractors. Both Parties are independent contractors under this Agreement.
Nothing herein contained shall be deemed to create an employment, agency, joint venture or
partnership relationship between the Parties hereto or any of their agents or employees, or any
other legal arrangement that would impose liability upon one Party for the act or failure to act of
the other Party. Neither Party shall have any express or implied power to enter into any contracts
or commitments or to incur any liabilities in the name of, or on behalf of, the other Party, or to
bind the other Party in any respect whatsoever.

     16.14 Counterparts. This Agreement may be executed in any number of counterparts, each of
which need not contain the signature of more than one Party but all such counterparts taken
together shall constitute one and the same agreement. Any signature page delivered by facsimile or
electronic image transmission shall be binding upon the Parties and shall be treated as if
originals. Any Party that delivers a signature page by facsimile or electronic image transmission
shall deliver an original counterpart to any other Party that requests such original counterpart.

{SIGNATURE PAGE FOLLOWS}

 

			
	[ * ]	 	 = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

82

 

     IN WITNESS WHEREOF, duly authorized representatives of the Parties have duly executed this
Agreement as of the Signing Date.

	 	 	 	 	 	 	 
	FACET BIOTECH CORPORATION	 	TRUBION PHARMACEUTICALS, INC.
	 
	By 

	/s/ Faheem Hasnain	 	By 
	/s/ Peter A. Thompson
	 	Name: 

	Faheem Hasnain
	 	 	Name: 
	Peter A. Thompson
	 	Title:

	President and Chief Executive Officer
	 	 	Title:
	President and Chief Executive Officer

 

			
	[ * ]	 	= Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

83

 

List of Exhibits

	 	 	 
	Exhibit A

	 	— TRU-016 Description
	Exhibit B

	 	— Initial Development Plan
	Exhibit C

	 	— Stock Purchase Agreement

List of Schedules

	 	 	 
	Schedule 1.132

	 	— Trubion Core Patent Rights
	Schedule 1.134

	 	— Trubion Product Patent Rights
	Schedule 3.7

	 	— Pre-existing Obligations
	Schedule 12.2

	 	— Disclosure Schedule

 

			
	[ * ]	 	 = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

84

 

Exhibit A (TRU-016 Description)

TRU-016 is a [ * ] composed of [ * ], the [ * ], the [ * ] and the [ * ]. The [ * ] has [ * ] and
[ * ] in a [ * ] by a [ * ], wherein the [ * ] are [ * ] from a [ * ] ([ * ]). The [ * ] is [ * ]
to the [ * ], the [ * ] and [ * ] of [ * ], through a [ * ]. TRU-016 [ * ] as [ * ] in [ * ] and
has a [ * ] of approximately [ * ].

Amino acid sequence:

[ * ]

 

			
	[ * ]	 	 = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

85

 

Exhibit B

Initial Development Plan

This is the Initial Development Plan under the Collaboration and License Agreement (the
“Collaboration Agreement”), dated August 27, 2009, between Facet Biotech Corporation
(“Facet”) and Trubion Pharmaceuticals, Inc. (“Trubion”).

TRU-016 Development Plan

All protocols and development plans involving TRU-016 and amendments thereto will be reviewed
and approved in accordance with the Collaboration Agreement. The [ * ] Trubion and Facet have
agreed to develop for TRU-016 are [ * ]. Trubion and Facet shall make good faith efforts to agree
upon the definitive Initial Development Plan and have it appropriately approved by the JSC within [
* ] after the Signing Date. The Development Plan will be reviewed and revised periodically and, if
necessary, after [ * ] in accordance with the terms of the Collaboration Agreement.

Clinical Development Plan

[ * ] of TRU-016 is [ * ] and [ * ] are being [ * ] for [ * ] in [ * ]. The [ * ] clinical
study [ * ] will be [ * ] if possible, to examine the [ * ] of [ * ] and [ * ] in [ * ] in [ * ]
setting; additionally, the study will be [ * ] to allow [ * ] with [ * ] until [ * ].

[ * ] additional trials will be in [ * ]; [ * ] will be [ * ] with [ * ] and [ * ] will be [ * ]
with [ * ] based on the [ * ] of these [ * ] in [ * ] study. The [ * ] additional study will
examine [ * ] of [ * ], [ * ] and possibly [ * ] or [ * ] in [ * ] in a [ * ] setting. The outline
of the programs in [ * ] and [ * ] are in the figures below. [ * ] criteria for [ * ] in [ * ] and
[ * ] in [ * ] are described as a way of example. The exact criteria for [ * ] will be [ * ] in
the field of [ * ] within the [ * ].

[ * ]

The table below outlines the timing and costs of the [ * ] and [ * ] trials. These are estimates
and will require refinement as the projects are developed. The costs are [ * ] and include [ * ],
and [ * ]; [ * ] and [ * ] are [ * ].

	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	Trial	 	Trial Start	 	DBL	 	Cost [ * ]	 	Cost [ * ]	 	Cost [ * ]	 	Cost [ * ]	 	Cost [ * ]	 	Cost [ * ]
	[ * ] Program

	 	 	 	 	 	$[ * ]	 	 	 	 	 	 	 	 	 	 
	[ * ], Phase [ * ] (Protocol [ * ])

	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	[ * ], Phase [ * ], [ * ]; [ * ]

	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	[ * ], Phase [ * ], [ * ]; [ * ]

	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	[ * ], Phase [ * ]; [ * ]; [ * ]

	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	[ * ] Program
	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	[ * ], Phase [ * ]; [ * ]

	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	[ * ], Phase [ * ], [ * ]; [ * ]

	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	[ * ], Phase [ * ]; [ * ]; [ * ]

	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]

 

			
	[ * ]	 	= Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

86

 

In addition to studies outlined above, [ * ] studies may be [ * ] by the [ * ]. These may
include a [ * ] and [ * ] in [ * ] with [ * ] or [ * ] to be conducted at appropriate times.

Studies in [ * ] and [ * ] ([ * ]) will be [ * ] after [ * ] are [ * ] from the [ * ]. It is
possible that trials in [ * ] ([ * ]) and [ * ] ([ * ]) [ * ] could [ * ] in the [ * ] of [ * ]. [
* ] but [ * ] and are [ * ] from the [ * ]. Hence, these [ * ] may be a [ * ] in [ * ]. The
objective of [ * ] trials in [ * ] and [ * ] would be to prove that [ * ] is [ * ]. Such [ * ] is
necessary in order to [ * ] a [ * ] that [ * ] in [ * ], as [ * ] and [ * ] are required for these
[ * ].

There are currently [ * ] FTEs supporting [ * ] ([ * ], [ * ], [ * ]). [ * ] FTEs at [ * ] or [ *
] may be required to support the planned studies in [ * ] and [ * ].

Manufacturing and Process Development Plans

Manufacturing History

[ * ] Product ([ * ] of [ * ])

The [ * ] of [ * ] which is [ * ] in the [ * ] was manufactured at [ * ] ([ * ]) [ * ] ([ * ]),
where about [ * ] of the product ([ * ]) were made in [ * ].

The [ * ] and [ * ] used to produce this [ * ] were a [ * ] with the [ * ] and [ * ] using [ * ] of
[ * ] and [ * ] with [ * ]. The [ * ] of [ * ] containing the [ * ] was prepared at [ * ] and
supplied to [ * ] ([ * ]) to prepare the [ * ] ([ * ]). The [ * ] was [ * ] by [ * ] and is [ * ]
at [ * ].

The manufacturing process (referred to as [ * ]) was [ * ] at [ * ] and [ * ] to [ * ] for [ * ].
[ * ] standard [ * ] of [ * ] was generated at [ * ] in [ * ] during the [ * ] of the [ * ] to [ *
]. Subsequently, [ * ] manufactured the [ * ] of [ * ] in a [ * ], followed by [ * ], [ * ], and [
* ]. The [ * ] had a [ * ] of [ * ]. The ensuing overall recovery of [ * ] was [ * ], with a
total of [ * ] of [ * ] generated.

The [ * ] of this [ * ] of [ * ] was packaged as a [ * ] for [ * ]. Each of the [ * ] contains [ *
] of [ * ] (or [ * ]) in the [ * ], as shown in the following table. The [ * ] system is a [ * ],
with a [ * ], [ * ] with an [ * ] with a [ * ]. The [ * ] are [ * ] at [ * ] at [ * ] ([ * ]).

Composition of [ * ], [ * ]

	 	 	 	 	 	 	 
	Ingredient	 	Reference	 	Function	 	Quantity (per mL)
	[ * ]

	 	[ * ]
	 	[ * ]
	 	[ * ]
	[ * ]

	 	[ * ]
	 	[ * ]
	 	[ * ]
	[ * ]

	 	[ * ]
	 	[ * ]
	 	[ * ]
	[ * ]

	 	[ * ]
	 	[ * ]
	 	[ * ]

[ * ] of [ * ]

A [ * ] process for [ * ] was [ * ] to [ * ] the [ * ] and [ * ] the [ * ] of [ * ] at the [ * ] in
[ * ]. The [ * ] by [ * ] was [ * ], to [ * ] it from the [ * ] ([ * ]) [ * ] in the [ * ]. The [
* ] and [ * ] system

 

			
	[ * ]	 	 = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

87

 

was [ * ] from [ * ]. The [ * ] based on the [ * ] ([ * ]) [ * ], and [ * ] were [ * ] in [ * ]
containing the [ * ] ([ * ]). A [ * ] of the [ * ] was [ * ] at [ * ] and [ * ] to [ * ] to [ * ]
and [ * ] an [ * ] for [ * ]. This [ * ] is [ * ] at [ * ] was [ * ] at [ * ] to [ * ] of [ * ] in
[ * ]. [ * ] process has [ * ] to the [ * ] procedure, [ * ] that the [ * ] was [ * ] to [ * ] to
[ * ] from the [ * ].

To provide a product that can be [ * ] and [ * ], a [ * ] for [ * ] was developed with [ * ] than [
* ]. The [ * ] was found to be [ * ] with [ * ] of a [ * ] of [ * ] at [ * ] (or [ * ]) in a [ *
] of [ * ], [ * ], and [ * ] at a [ * ] of [ * ], as shown in the following table.

Composition of [ * ], [ * ]

	 	 	 	 	 	 	 
	Ingredient	 	Reference	 	Function	 	Quantity (per mL)
	[ * ]

	 	[ * ]
	 	[ * ]
	 	[ * ]
	[ * ]

	 	[ * ]
	 	[ * ]
	 	[ * ]
	[ * ]

	 	[ * ]
	 	[ * ]
	 	[ * ]
	[ * ]

	 	[ * ]
	 	[ * ]
	 	[ * ]

Following the development work, a [ * ] production of [ * ] was executed with the [ * ]
process in [ * ] at [ * ] in [ * ]. The [ * ] contained [ * ] of [ * ], or a total of [ * ] of [ *
]. The overall cumulative yield of the [ * ] was [ * ].

The [ * ] of [ * ] into [ * ] and its [ * ] into [ * ] was done at [ * ] ([ * ]) in [ * ]. The [ *
] of the [ * ] and the [ * ] of [ * ] was [ * ], and the [ * ] of the [ * ] of [ * ] is [ * ]. A
total of [ * ] were manufactured, and after retaining some [ * ] for [ * ] and [ * ], [ * ] (for a
total of [ * ] of [ * ]) are available for [ * ]. [ * ] of this [ * ] to [ * ] standard [ * ] by [
* ] and [ * ] has been established, and an [ * ] to [ * ] on [ * ] to pave the way for [ * ] the [
* ] to the [ * ].

Further [ * ] Plans

The current [ * ] process with [ * ] of about [ * ] and [ * ] of [ * ] is suitable for [ * ] for [
* ] and represnts the [ * ] for [ * ] of [ * ]. However, improvements to [ * ] and [ * ] are [ * ]
to further [ * ] and [ * ] in [ * ] manufacturing. [ * ] changes, such as [ * ] to [ * ] materials
([ * ], etc.), will [ * ]. Throughout these [ * ], the [ * ] of the product from the [ * ] to the
current [ * ] in [ * ] will be demonstrated.

Work is currently under way in [ * ] to [ * ] the [ * ] of the [ * ] process. So far, areas
already successful have been:

	 	•	 	To [ * ] the [ * ] of [ * ] (currently at [ * ]) in the [ * ] process leading to the [ *
] to allow [ * ];
	 
	 	•	 	To [ * ] the [ * ] of [ * ] in the [ * ] to achieve [ * ]
	 
	 	•	 	To design a process with [ * ] for [ * ].

With some of these changes [ * ], a [ * ] process [ * ] in the [ * ] and of [ * ] to [ * ] has
already been demonstrated in [ * ] and will shortly be tested with [ * ].

The [ * ] of the [ * ] process will also be examined. Attempts are currently being made to:

	 	•	 	[ * ] the [ * ] to allow the [ * ]. [ * ] of [ * ] conditions is being pursued to [ * ]
the [ * ].
	 
	 	•	 	[ * ] the amount of [ * ] entering the [ * ] by treating the [ * ] or [ * ] to further [
* ] the [ * ].

 

			
	[ * ]	 	 = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

88

 

For the drug product, [ * ] efforts will look into [ * ] of [ * ] in [ * ], and [ * ] through:

	 	•	 	[ * ] the product [ * ] to [ * ] and [ * ] in [ * ] to get a [ * ] of [ * ] ([ * ] data
indicate [ * ] of [ * ] or [ * ] are [ * ]). The need for this effort will be assessed in
light of the intended [ * ] in consulation with the program team.
	 
	 	•	 	Assessing [ * ] of [ * ]. The current [ * ] capacity at [ * ] ([ * ]) is in the process
of being [ * ] which would offer the possibility of [ * ].
	 
	 	•	 	An evaluation of [ * ] data on [ * ] would be done to assess [ * ] of a [ * ] should
that be considered desirable for [ * ] purposes.

In the area of [ * ], the following [ * ] will be investigated as [ * ] to the [ * ] process:

	 	•	 	A [ * ] to determine [ * ] of the [ * ] in various process [ * ], including [ * ] and [
* ];
	 
	 	•	 	A [ * ];
	 
	 	•	 	[ * ] methods to [ * ] current [ * ] methods
	 
	 	•	 	A [ * ] method as [ * ] test;
	 
	 	•	 	More [ * ] methods to characterize [ * ] and [ * ] improvements.
	 
	 	•	 	Other [ * ] for [ * ] characterization of [ * ] and [ * ] for various [ * ] evaluations
[ * ] by [ * ] and [ * ] and [ * ] for various [ * ] and [ * ]

Clinical Drug [ * ]

The current [ * ] drug product ([ * ], [ * ]) will be used in the Phase [ * ] study. Additional
drug product ([ * ]) from the [ * ] manufacturing process is expected in [ * ]. [ * ] between the [
* ] and the [ * ] has been established and an [ * ] for the [ * ] of [ * ] on [ * ]. The timing of
[ * ] will depend on [ * ] needs; at a minimum, a [ * ] in [ * ] will be [ * ] to [ * ] the [ * ]
in [ * ].

For planning purposes, the best estimate of [ * ] at this time is assumed to be [ * ], for a total
of [ * ]. The table on the next page lists the projected material requirements for the [ * ] in [
* ].

[ * ]

	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	Study	 	Start	 	DBL	 	[ * ]	 	[ * ]	 	[ * ]	 	[ * ]	 	[ * ]
	[ * ]

	 	[ * ]
	 	[ * ]
	 	[ * ]	 	 	 	 	 	 	 	 
	[ * ]

	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]	 	 	 	 	 	 
	[ * ]

	 	[ * ]
	 	[ * ]
	 	 	 	[ * ]
	 	[ * ]	 	 	 	 
	[ * ]

	 	[ * ]
	 	[ * ]
	 	 	 	[ * ]
	 	[ * ]	 	 	 	 
	[ * ]

	 	[ * ]
	 	[ * ]
	 	 	 	 	 	 	 	[ * ]
	 	[ * ]
	[ * ]

	 	[ * ]
	 	[ * ]
	 	 	 	[ * ]
	 	[ * ]	 	 	 	 
	 
	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	Total [ * ]

	 	 	 	 	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 
	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	No. of [ * ]:
	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	[ * ]

	 	 	 	 	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 
	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	[ * ]
	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	[ * ]

	 	 	 	 	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	[ * ]

	 	 	 	 	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	[ * ]

	 	 	 	 	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]

 

			
	[ * ]	 	= Certain confidential information contained in this document, marked by brackets, has been
omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of
the Securities Exchange Act of 1934, as amended.

89

 

[ * ]

Assumptions

[ * ]

[ * ]

The current [ * ] for TRU-016 are [ * ]. Key inputs for [ * ] calculations are [ * ] and [ * ].
The current trial has reached a [ * ] so the [ * ] is if the [ * ] does not [ * ] from that level.
The [ * ] range for [ * ] is estimated around [ * ] per [ * ]. While considering these [ * ]
variables, [ * ] parameters have to be taken into account in estimating the [ * ]. For
illustration purposes, calculations below assume that the [ * ] is [ * ], [ * ] per [ * ], and the
total [ * ] is [ * ] (for a [ * ]). As the [ * ] and [ * ] will play an important role in
determining the [ * ], the following table focuses on these [ * ].

	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	Total [ * ] per [ * ]	 	[ * ] as a
	[ * ]	 	[ * ]	 	(including [ * ])	 	percentage of $[ * ]
	[ * ]
	 	 	[ * ]	 	 	$	[ * ]	 	 	 	[ * ]	%
	[ * ]
	 	 	[ * ]  	 	 	$	[ * ]	 	 	 	[ * ]	%
	 
	 	[ * ] (Currently [ * ])	 	$	[ * ]	 	 	 	[ * ]	%
	[ * ]
	 	[ * ] (per [ * ])	 	$	[ * ]	 	 	 	[ * ]	%
	 
	 	[ * ] (currently [ * ])	 	$	[ * ]	 	 	 	[ * ]	%

As seen from the above estimates, the [ * ] are [ * ] and could be [ * ] by implementing]the [ * ]
and selecting a [ * ]. Since the process that will be [ * ] at [ * ] will [ * ] be the [ * ]
process, the decision for [ * ] will be made after careful, detailed discussion regarding the [ * ]
for [ * ].

[ * ] and [ * ]

[ * ] and [ * ] activities have to be planned to meet the [ * ] time line. The [ * ] of the [ * ]
process will consist of [ * ] testing of [ * ], during which [ * ] and [ * ] for the [ * ], and [ *
] will be identified and characterized, followed by the [ * ] of the [ * ] to [ * ] and [ * ]
composed of [ * ] ([ * ] of up to [ * ]), [ * ] of [ * ], and [ * ] on both [ * ] and [ * ]. [ * ]
will be conducted [ * ] to [ * ].

The [ * ] is expected to require [ * ] from the [ * ] of the [ * ] to [ * ] of the [ * ], with the
[ * ] studies [ * ] that.

The estimated timeline, [ * ] requirements and [ * ] estimates for [ * ] are shown in the Figure
below based on [ * ] assumptions. Please note that [ * ] in [ * ] for [ * ] are [ * ] only in the
[ * ], although [ * ] would be [ * ] to [ * ] the [ * ] activities in the [ * ]. [ * ] indicated
are estimates for [ * ] for activities at [ * ] and [ * ].

 

			
	[ * ]	 	 = Certain confidential information contained in this document, marked by brackets, has
been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule
24b-2 of the Securities Exchange Act of 1934, as amended.

90

 

[ * ]*

     [ * ]

* [ * ] would be [ * ] to [ * ] the [ * ] activities. [ * ] indicated are estimates for [ * ]
for activities at [ * ] and [ * ].

[ * ]

For the purpose of [ * ], it is assumed that the [ * ] process with [ * ] in [ * ] will be
implemented for the [ * ] in [ * ]. Also, assuming the need for [ * ] along with [ * ], [ * ] are
planned. In the table below, separate estimates for [ * ] and [ * ] are shown for the [ * ].
These estimates were developed by [ * ] prior to [ * ] and may [ * ] as a [ * ] a [ * ] in the [ *
].

     [ * ] Process, [ * ] – [ * ] and [ * ]

	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	Timing	 	[ * ]	 	[ * ]	 	[ * ]	 	[ * ]
	Activity
	 	 	[ * ]	 	 	 	[ * ]	 	 	 	[ * ]	 	 	 	[ * ]	 
	No. of [ * ]
	 	 	[ * ]	 	 	 	[ * ]	 	 	 	[ * ]	 	 	 	[ * ]	 
	[ * ]
	 	 	[ * ]	 	 	 	[ * ]	 	 	 	[ * ]	 	 	 	[ * ]	 
	[ * ]
	 	 	 	 	 	 	[ * ]	*	 	 	 	 	 	 	[ * ]	**

 

			
	 	 	*[ * ]
	 
	 	 	**[ * ]

Preclinical Development Plan

The purpose of the research program is to:

	 	•	 	provide [ * ] for [ * ] from [ * ] and other [ * ] for [ * ] and [ * ]
	 
	 	•	 	explore [ * ] of [ * ] and provide [ * ] for [ * ] in the [ * ]
	 
	 	•	 	[ * ] and [ * ] in clinical development by [ * ] patient populations responsive] or [ *
] to [ * ]

[ * ]

[ * ] of the [ * ]

Technology exists at [ * ] to facilitate [ * ] of the [ * ] on [ * ] for [ * ]. The studies would
employ either [ * ] or [ * ] of the [ * ] followed by [ * ] studies of [ * ]. Requirements for
this approach would be the identification of a [ * ] that allows for [ * ] and [ * ] of [ * ] to [
* ] with [ * ].

[ * ] for [ * ] 

 

			
	[ * ]	 	 = Certain confidential information contained in this document, marked by brackets, has
been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule
24b-2 of the Securities Exchange Act of 1934, as amended.

91

 

[ * ]

Studies to date have shown that [ * ] from [ * ] in the [ * ] and [ * ] for [ * ] on [ * ] ([ * ];

[ * ] data). This work will be extended to a [ * ] of [ * ] from [ * ] and available [ * ]. ([ * ]

are defined in this preclinical section as [ * ] from [ * ] without [ * ].) [ * ] activity will

also be [ * ] with other [ * ] on [ * ] as has been done on [ * ]. (See table below.)

Studies [ * ] Activity [ * ] and [ * ]

	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	[ * ]	 	[ * ]	 	Scope of Work	 	[ * ] Resources	 	[ * ]
	[ * ]
	 	 	[ * ]	 	 	 	[ * ]	 	 	 	[ * ]	 	 	 	[ * ]	 
	[ * ]
	 	 	[ * ]	 	 	 	[ * ]	 	 	 	[ * ]	 	 	 	[ * ]	 
	[ * ]
	 	 	[ * ]	 	 	 	[ * ]	 	 	 	[ * ]	 	 	 	[ * ]	 

     Key [ * ]

In addition, previous studies have shown that [ * ] to [ * ] on [ * ] by a [ * ] that is [ * ]
from [ * ] and other [ * ] ([ * ]). These and further studies detailing [ * ] of [ * ] will also be
used to guide [ * ] of [ * ] to [ * ] with [ * ]. The timing for completion of the studies in
Table 1 is as follows:

	 	•	 	[ * ]: prior to [ * ] of the [ * ].
	 
	 	•	 	[ * ]: prior to [ * ] of [ * ]
	 
	 	•	 	[ * ]: prior to [ * ]

Finally, [ * ] studies which include [ * ] should be included to examine the [ * ] of [ * ] in the
[ * ] responses. In addition, [ * ] studies (e.g., [ * ]) of [ * ] to a variety of [ * ] should be
conducted.

[ * ]

Previous studies have shown that [ * ] has [ * ] activity on [ * ] when [ * ] to [ * ] or [ * ].
These studies will be [ * ] to [ * ] from [ * ] of [ * ] and also examined on [ * ]. In addition,
studies suggest that [ * ] can [ * ] ([ * ]). [ * ] studies with [ * ] will be performed to see if
the [ * ] of [ * ] by [ * ] it [ * ] to this [ * ] to [ * ].

[ * ] – [ * ] Studies

The following table outlines the planned [ * ] of [ * ] activity and [ * ]. The studies are
designed to examine [ * ] in a [ * ] and when [ * ] serve as the [ * ] for [ * ].

[ * ] Activity

	 	 	 	 	 	 	 	 	 
	[ * ]	 	[ * ]	 	Resources
	[ * ]
	 	 	[ * ]	 	 	 	[ * ]	 
	[ * ]*
	 	 	[ * ]	 	 	 	[ * ]	 

			
	*	 	[ * ]

 

			
	[ * ]	 	= Certain confidential information contained in this document, marked by brackets, has
been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule
24b-2 of the Securities Exchange Act of 1934, as amended.

92

 

[ * ] Drug [ * ] Studies

As presented in the [ * ] section of this document, [ * ], particularly for [ * ], will involve [ *

] of [ * ] in [ * ]. Therefore, [ * ] work has begun to provide [ * ] for [ * ] likely to [ * ].

The figure below shows the [ * ] results of [ * ] with [ * ] on [ * ] of the [ * ] and on the [ *

]. [ * ] with [ * ] often giving [ * ] activity and [ * ] have been [ * ].

[ * ] with [ * ] on [ * ] by [ * ] Analysis

[ * ]

The tables below provide a summary of [ * ] experiments [ * ] and [ * ], respectively.

[ * ] Drug [ * ] Studies

	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 	 	 	[ * ]	 	 
	[ * ]	 	[ * ]	 	Scope of work	 	resources	 	[ * ]
	[ * ]
	 	 	[ * ]	 	 	 	[ * ]	 	 	 	[ * ]	 	 	 	[ * ]	 
	[ * ]
	 	 	[ * ]	 	 	 	[ * ]	 	 	 	[ * ]	 	 	 	[ * ]	 
	[ * ]
	 	 	[ * ]	 	 	 	[ * ]	 	 	 	[ * ]	 	 	 	[ * ]	 
	[ * ]
	 	 	[ * ]	 	 	 	[ * ]	 	 	 	[ * ]	 	 	 	 	 

     Key: [ * ]

[ * ] Drug [ * ] Studies

	 	 	 	 	 	 	 	 	 	 	 	 	 
	[ * ]	 	[ * ]	 	[ * ]	 	Notes
	[ * ]
	 	 	[ * ]	 	 	 	[ * ]	 	 	 	[ * ]	 
	
 	 	 	[ * ]	 	 	 	[ * ]	 	 	 	[ * ]	 
	[ * ]
	 	 	[ * ]	 	 	 	[ * ]	 	 	 	[ * ]	 
	 
	 	 	[ * ]	 	 	 	[ * ]	 	 	 	[ * ]	 
	[ * ]
	 	 	[ * ]	 	 	 	[ * ]	 	 	 	[ * ]	 
	[ * ]
	 	 	[ * ]	 	 	 	[ * ]	 	 	 	 	 
	[ * ]
	 	 	[ * ]	 	 	 	[ * ]	 	 	 	 	 
	[ * ]
	 	 	[ * ]	 	 	 	[ * ]	 	 	 	 	 
	[ * ]
	 	 	[ * ]	 	 	 	[ * ]	 	 	 	 	 
	 	 	[ * ]	 	 	 	[ * ]	 	 	 	[ * ]	 

Identification of [ * ] for [ * ] Study 

 

			
	[ * ]	 	 = Certain confidential information contained in this document, marked by brackets, has
been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule
24b-2 of the Securities Exchange Act of 1934, as amended.

93

 

Typically, attempts to identify [ * ] for [ * ] occur during the [ * ] of [ * ] investigation
as they require [ * ] of [ * ] prior to [ * ] with the [ * ] and then [ * ] with [ * ]. [ * ]
samples are used to [ * ] the [ * ]. These studies often require [ * ] and [ * ] such as [ * ], [
* ], [ * ], or [ * ] for [ * ] in [ * ].

However, [ * ] is [ * ] to [ * ] in [ * ] investigation and has [ * ] to [ * ] including those from
[ * ] in the [ * ]. Studies will [ * ] to identify [ * ] of the [ * ] of [ * ] activity on [ * ]
and then test [ * ] these [ * ] also [ * ]. [ * ] is creating [ * ] of these [ * ] for [ * ]
studies. A similar strategy is contemplated for [ * ] such as [ * ].

If the current studies of [ * ] activity [ * ] that [ * ] from some [ * ] to [ * ] or in [ * ],
then [ * ] will be [ * ] by:

	 	•	 	[ * ] whether the [ * ] has a [ * ] with [ * ] and [ * ] for [ * ] in [ * ] and
	 
	 	•	 	[ * ] with [ * ] (e.g. [ * ]) that have [ * ] and [ * ] in place to [ * ] for [ * ] to [
* ].

The [ * ] status and [ * ] would then be [ * ] for [ * ] from [ * ] were [ * ] with [ * ] to [ * ]
if the [ * ] of [ * ] do [ * ] with [ * ].

Additional [ * ] studies that have been identified:

	 	•	 	Examine [ * ] data for [ * ] on [ * ] and [ * ] to [ * ] to [ * ] or [ * ] a [ * ] of [ * ].
	 
	 	•	 	Examine [ * ] of [ * ] following [ * ] with [ * ] to [ * ] with [ * ] (in [ * ] in [ * ])
	 
	 	•	 	[ * ] studies to [ * ] with [ * ] in [ * ]:

	 	•	 	Examine [ * ] and [ * ] in [ * ]
	 
	 	•	 	Examine [ * ] and [ * ] in [ * ] (e.g., [ * ] and [ * ] for [ * ], or other [ * ]).

[ * ] – [ * ]

[ * ]

[ * ]

[ * ]

Status: [ * ].

[ * ] have been [ * ] with [ * ], the [ * ] of [ * ], for the purposes of pursuing the following
research:

	 	1.	 	Further defining [ * ] in [ * ].

	 	a.	 	Identification of [ * ] for [ * ].
	 
	 	b.	 	Investigation of the [ * ].
	 
	 	c.	 	Looking at [ * ] in [ * ] other [ * ], including those that [ * ],
namely [ * ] and [ * ].

	 	2.	 	[ * ] model.

	 	a.	 	[ * ] including in [ * ].
	 
	 	b.	 	Investigate [ * ].
	 
	 	c.	 	Investigate role of [ * ] and [ * ].

	 	i.	 	[ * ].
	 
	 	ii.	 	[ * ] of [ * ] such as with [ * ].
	 
	 	iii.	 	If a role for [ * ] is determined, investigate the [ * ] of [ *
] in the model.

	 	3.	 	[ * ] model

	 	a.	 	Investigate [ * ] in a [ * ] model

 

			
	[ * ]	 	 = Certain confidential information contained in this document, marked by brackets, has
been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule
24b-2 of the Securities Exchange Act of 1934, as amended.

94

 

          b. Investigate [ * ] of [ * ]. If so, investigate whether this [ * ] for
[ * ]

     4. Investigate whether [ * ] is [ * ] by [ * ] than [ * ] due to [ * ].

     5. Investigate whether [ * ] and [ * ] show [ * ].

          a. If so, what is the [ * ]? Possibly [ * ] or [ * ].

Results from [ * ] were [ * ]:

Effect of [ * ] on [ * ] in [ * ] via [ * ] of the [ * ], [ * ].

The studies demonstrated that [ * ] in [ * ] occurs via [ * ] of [ * ]. This work demonstrates that
[ * ] utilizes a [ * ] of [ * ] in [ * ] other [ * ] for [ * ]. Additionally, the data provides a [
* ] for the [ * ] of [ * ] ([ * ]) observed to date in [ * ].

[ * ]

[ * ]

[ * ]

Status: [ * ].

[ * ] will be [ * ] with [ * ], a [ * ]. This [ * ] is the [ * ] of the [ * ].

The [ * ] has [ * ] objectives.

1. The [ * ] activity of [ * ] will be studied [ * ] using [ * ] ([ * ]) and [ * ] ([ * ]) [ * ].

	 	 	This [ * ] has been developed to [ * ] as [ * ] and [ * ] represent a [ * ] of [ * ]. This
[ * ] has been utilized previously by [ * ] to examine the [ * ] of other [ * ] for [ * ],
including [ * ] and [ * ] ([ * ]), [ * ] ([ * ]) and [ * ] ([ * ]).

2. The effects of [ * ] will be tested [ * ] and [ * ] with [ * ] to [ * ] of [ * ] in [ * ].

	 	 	[ * ] will be [ * ] with (and [ * ]) [ * ], [ * ] or [ * ] into [ * ] (carrying [ * ]). [ *
] and [ * ] will be determined utilizing appropriate [ * ].

[ * ]

[ * ]

Status: [ * ].

[ * ] to use [ * ] technology to [ * ] some [ * ] and [ * ] in [ * ] to determine if [ * ] is [ *] to [ * ].

Specifically, [ * ] and [ * ] will be explored using [ * ] for [ * ] analysis of [ * ](e.g. [ * ] or [ * ])

[ * ]

[ * ]

Status: [ * ]. [ * ] plans to study the [ * ] of [ * ] and whether [ * ] by [ * ] renders it [ * ]
to [ * ] by [ * ].

[ * ]for [ * ] and [ * ] ([ * ])

The major approach for [ * ] from [ * ] for [ * ] will involve [ * ] of [ * ] on [ * ] that have [* ] and [ * ] of [ * ] between [ * ] and [ * ] on [ * ]. This [ * ] of [ * ] data that:

	 	•	 	[ * ] that [ * ] and [ * ] does [ * ] for the [ * ] ([ * ]), with [ * ] on more [ * ]
such as [ * ]
	 
	 	•	 	and that [ * ] may also be [ * ] on [ * ] such as [ * ] and some [ * ] and play a role
in [ * ] ([ * ]; and [ * ] data on [ * ])

 

			
	[ * ] =	 	Certain confidential information contained in this document, marked by brackets, has
been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule
24b-2 of the Securities Exchange Act of 1934, as amended.

95

 

Because [ * ] may [ * ] in the [ * ] of [ * ] such as [ * ], and [ * ], [ * ] on [ * ] could [ * ]
of [ * ] from [ * ]. The following table outlines the [ * ] studies.

Another approach to [ * ] will be [ * ] of the [ * ] of [ * ] and [ * ] to [ * ] from [ * ] after [
* ] into [ * ].

[ * ] on [ * ] and the [ * ] of these studies, [ * ] demonstrating [ * ] on [ * ] by [ * ] in the [
* ] of [ * ] will be [ * ] for [ * ] with [ * ].

     Studies to Examine [ * ] and [ * ]

	 	 	 	 	 	 	 	 	 
	[ * ]	 	[ * ]	 	[ * ]	 	[ * ]	 	[ * ]
	[ * ]

	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 
	 	 	 	 	 	 	 	 
	 

	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	*[ * ]
	 
	 	 	 	 	 	 	 	 
	[ * ]

	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	[ * ]
	 
	 	 	 	 	 	 	 	 
	 

	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	*[ * ]
	 
	 	 	 	 	 	 	 	 
	[ * ]

	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	*[ * ]
	 
	 	 	 	 	 	 	 	 
	[ * ]

	 	[ * ]
	 	[ * ]
	 	[ * ]	 	 
	 
	 	 	 	 	 	 	 	 
	[ * ]

	 	[ * ]
	 	[ * ]
	 	[ * ]
	 	        [ * ]**

 

			
	 	 	*[ * ] studies for [ * ] will involve studies on [ * ] and [ * ].
	 
	 	 	**Given that [ * ] does [ * ] with [ * ] or [ * ], examining [ * ] of [ * ] in [ * ] is [ * ]. As
[ * ], [ * ] of [ * ] in the [ * ] would allow for the [ * ] of [ * ] and other [ * ] (e.g., [ *
]) [ * ]. [ * ] at [ * ] would be [ * ]. However, [ * ] is [ * ] of a [ * ] that may be [ * ] for
[ * ] of experiments.

[ * ] studies will be undertaken to [ * ] the [ * ] by [ * ] can be [ * ] into [ * ]. [ * ]
will be [ * ] to provide a [ * ]. The timing for [ * ] of these studies is as follows:

	 	•	 	[ * ] studies: Prior to [ * ]
	 
	 	•	 	[ * ]: Prior to [ * ]

[ * ] — [ * ]

[ * ]

[ * ]

[ * ]

Status: [ * ]

[ * ] will develop [ * ] and [ * ] ([ * ]) [ * ] and [ * ] in [ * ]. In addition, a [ * ] will be

[ * ] and [ * ] in [ * ] will be [ * ] in [ * ]. [ * ] will be [ * ], including [ * ].

 

			
	[ * ] =	 	Certain confidential information contained in this document, marked by brackets, has
been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule
24b-2 of the Securities Exchange Act of 1934, as amended.

96

 

     [ * ] Costs

Estimated [ * ]

	 	 	 	 	 	 	 	 	 	 	 
	Dept	 	 	 	[ * ]	 	[ * ]	 	[ * ]	 	[ * ]
	[ * ]
	 	[ * ]	 	[ * ]	 	[ * ]	 	[ * ]	 	[ * ]
	 
	 	[ * ]	 	 	 	 	 	[ * ]	 	[ * ]
	 
	 	[ * ]	 	[ * ]	 	[ * ]	 	[ * ]	 	[ * ]
	 
	 
	 	Total	 	[ * ]	 	[ * ]	 	[ * ]	 	[ * ]
	 

Estimated [ * ] Costs ([ * ] $)

	 	 	 	 	 	 	 	 	 	 	 
	Dept	 	 	 	[ * ]	 	[ * ]	 	[ * ]	 	[ * ]
	[ * ]
	 	[ * ]	 	 	 	[ * ]	 	[ * ]	 	[ * ]
	 
	 	[ * ]	 	[ * ]	 	[ * ]	 	[ * ]	 	[ * ]
	 
	 	[ * ]	 	 	 	[ * ]	 	[ * ]	 	[ * ]
	 
	 	[ * ]	 	 	 	[ * ]	 	[ * ]	 	 
	 
	 
	 	Total	 	[ * ]	 	[ * ]	 	[ * ]	 	[ * ]
	 

 

			
	[ * ] =	 	Certain confidential information contained in this document, marked by brackets, has
been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule
24b-2 of the Securities Exchange Act of 1934, as amended.

97

 

EXHIBIT C

STOCK PURCHASE AGREEMENT

     This Stock Purchase Agreement (this “Agreement”) is made and entered into as of
August 27, 2009 (the “Execution Date”) by and between Trubion Pharmaceuticals, Inc., a
Delaware corporation having a principal place of business at 2401 4th Avenue, Suite 1050, Seattle,
Washington 98121 (including, unless the context otherwise requires, its subsidiaries, the
“Company”), and Facet Biotech Corporation, a Delaware corporation having a principal place
of business at 1500 Seaport Blvd., Redwood City, CA 94063 (“Purchaser”). The Company and
Purchaser are sometimes referred to herein individually as a “Party” and collectively as the
”Parties.”

RECITALS

     Whereas, concurrently herewith, the Company and Purchaser have entered into an
arrangement whereby Purchaser will license certain technology from the Company pursuant to that
certain Collaboration and License Agreement dated as of the Execution Date (the “Collaboration
Agreement”); and

     Whereas, in connection with the transactions contemplated by the Collaboration
Agreement, the Company and Purchaser each desire for Purchaser to purchase from the Company newly
issued shares of the Company’s common stock, $0.001 par value per share (the “Common
Stock”), in the amounts and on the terms and conditions set forth in this Agreement.

AGREEMENT

     Now, Therefore, in consideration of the foregoing recitals and the following mutual
promises and covenants, the Parties agree as follows:

1. AUTHORIZATION AND SALE OF SHARES

1.1 Authorization. The Company has authorized the issuance and sale of the shares of Common Stock
pursuant to the terms and conditions of this Agreement.

1.2 Issuance and Sale. Subject to the terms and conditions of this Agreement, on the Closing Date
(as defined in Section 2.1(a)), the Company shall issue and sell to Purchaser, and Purchaser shall
purchase from the Company 2,243,649 shares of Common Stock (the “Shares”) for an aggregate
purchase price of Ten Million Dollars ($10,000,000). In the event of any stock split, stock
dividend, combination of shares, recapitalization or other change in the structure of the Company
prior to the Closing Date that affects or relates to the Common Stock, the number of Shares shall
be adjusted proportionately.

 

			
	[ * ] =	 	Certain confidential information contained in this document, marked by brackets, has
been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule
24b-2 of the Securities Exchange Act of 1934, as amended.

98

 

2. CLOSING; CLOSING DELIVERIES

2.1 Closing.

(a) Closing Date. The closing of the purchase and sale of the Shares as contemplated in this
Agreement (the “Closing”) and the delivery of documents contemplated to be delivered at the
Closing shall take place at 10:00 a.m. Pacific Time on the date which is 3 business days after the
date on which all conditions to the obligations of the Parties to consummate the transactions
hereunder regarding the Shares shall have been satisfied and/or waived, or such other place or
later time as Purchaser and the Company shall agree (the date on which the Closing occurs being
referred to herein as the “Closing Date”).

(b) Location of Closing. The Closing shall be held at the Company’s principal offices, 2401 4th
Avenue, Suite 1050, Seattle, Washington 98121, or at such other place as the Company and Purchaser
may agree in writing.

2.2 Closing Deliveries.

(a) Deliveries by the Company. Subject to the terms and conditions of this Agreement, at the
Closing the Company shall deliver to Purchaser:

     (i) a copy of irrevocable instructions from the Company to the Company’s stock transfer agent
dated no later than the Closing Date, which directs the Company’s transfer agent to prepare and
deliver to Purchaser a stock certificate representing the Shares as soon as practicable following
the Closing;

     (ii) a legal opinion of counsel to the Company in a form reasonably acceptable to counsel for
Purchaser, dated as of the Closing Date;

     (iii) a certificate executed by the Company’s Chief Executive Officer and Senior Vice
President, General Counsel and Corporate Secretary, dated as of the Closing Date, to the effect
that the conditions set forth in Sections 7.1(a) and 7.1(b) have been satisfied.

(b) Deliveries by Purchaser. Subject to the terms and conditions of this Agreement, at the
Closing, Purchaser shall deliver to the Company:

     (i) Ten Million Dollars ($10,000,000) by wire transfer in immediately available funds to such
account as the Company may notify Purchaser in writing (including by email) at least two trading
days prior to the Closing Date; and

     (ii) a certificate executed by an executive officer of Purchaser, dated as of the Closing
Date, to the effect that the conditions set forth in Sections 7.2(a) and 7.2(b) have been
satisfied.

3. REPRESENTATIONS AND WARRANTIES OF THE COMPANY

3.1 Representations and Warranties. Except as set forth in the Disclosure Schedule delivered by
the Company to Purchaser prior to the execution of this Agreement (the “Company Disclosure
Schedule”), and then to the extent the Company Disclosure Schedule specifically

 

			
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been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule
24b-2 of the Securities Exchange Act of 1934, as amended.

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identifies each exception by specific subsection references (it being understood that any
information disclosed therein shall be deemed to be disclosed and incorporated in any other section
where such disclosure would be appropriate and reasonably apparent), the Company hereby represents
and warrants the following as of the Execution Date and as of the Closing Date:

(a) Corporate Organization and Authority. The Company:

     (i) is a corporation duly organized, validly existing and in good standing under the laws of
the State of Delaware;

     (ii) has the corporate power and authority to own, lease and operate its properties and to
carry on its business as now conducted and as proposed to be conducted;

     (iii) has the corporate power and authority to enter into this Agreement and to carry out the
transactions contemplated herein; and

     (iv) is qualified as a foreign corporation and in good standing in all jurisdictions in which
such qualification is required, except for any such jurisdiction in which the Company’s failure to
qualify would not have a Material Adverse Effect (as defined in Section 3.1(c)(ii)).

(b) Authorization. All necessary corporate action on the part of the Company for the execution and
delivery of this Agreement and the issuance and delivery of the Shares being issued on the Closing
Date has been taken. This Agreement constitutes a valid and legally binding obligation of the
Company enforceable in accordance with its terms.

(c) No Conflicts; Required Filings.

     (i) The performance by the Company of this Agreement and the transactions contemplated herein
do not violate, conflict with or constitute a default under, and will not result in any violation
of, be in conflict with or constitute a default under, with or without the passage of time or the
giving of notice of (1) any provision of the Company’s charter or bylaws as in effect on the
Execution Date and the Closing Date; (2) any provision of any judgment, decree or order to which
the Company is a party or by which it or any of its properties is bound; (3) any contract,
obligation or commitment to which the Company is a party or by which it or any of its properties is
bound, which violation or default would, individually or in the aggregate, have a Material Adverse
Effect; or (4) any statute, rule or governmental regulation applicable to the Company, which
violation or default would, individually or in the aggregate, (A) prevent or materially delay
consummation of the transaction contemplated under this Agreement, (B) otherwise have a material
adverse effect on the ability of the Company to perform its obligations under this Agreement or (C)
individually or in the aggregate, result in any change, event, development, effect or condition
that is or is reasonably likely to be materially adverse to the assets, liabilities, business,
financial condition or results of operations of the Company and its subsidiaries, taken as a whole
(each of the foregoing items in (A), (B) or (C) being referred to herein as “Material Adverse
Effect”).

     (ii) The execution, delivery and performance by the Company of this Agreement and the
transactions contemplated herein do not and will not require any consent, approval,

 
 

			
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been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule
24b-2 of the Securities Exchange Act of 1934, as amended.

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authorization or permit of, or filing with or without notification to, any governmental or
regulatory authority, United States or foreign, except for applicable requirements, if any, of the
Securities Act of 1933, as amended (the “Securities Act”) and the Securities Exchange Act
of 1934, as amended, including the rules and regulations promulgated thereunder (the “Exchange
Act”), or securities laws of the various states of the United States (the “Blue Sky Laws”).

(d) Capital Stock.

     (i) As of August 26, 2009 (the “Capitalization Date”), the authorized capital stock of
the Company consisted of 150,000,000 shares of Common Stock, $0.001 par value per share, of which
18,110,515 shares were issued and outstanding. As of the Capitalization Date, 2,403,375 shares of
Common Stock were reserved for issuance under outstanding stock options pursuant to the Company’s
stock option plans, and 1,780,016 shares were reserved for future issuance in connection with the
Company’s stock option plans. All of the outstanding shares of the Company’s capital stock are
validly issued, fully paid and nonassessable and were issued in compliance with all applicable
federal and state securities laws, except as would not have a Material Adverse Effect. Except as
described above and as set forth in the SEC Reports (as defined in Section 3.1(f)(i)), (1) the
Company has not agreed to register the sale of any of its securities under the Securities Act and
(2) there are no outstanding subscriptions, options, warrants, calls, contracts, demands,
commitments, conversion rights or other agreements or arrangements of any character or nature
whatever under which the Company is or may be obligated to issue its Common Stock, preferred stock
or warrants, options or other securities exercisable for the purchase of, convertible into or
exchangeable or extinguishable for, Common Stock or preferred stock.

     (ii) The Company has reserved a sufficient number of shares of Common Stock for issuance to
Purchaser in accordance with the Company’s obligations under this Agreement.

     (iii) Except as disclosed in the SEC Reports, there are no outstanding contractual obligations
of the Company (1) restricting the transfer of, (2) affecting the voting rights of, (3) requiring
the repurchase, redemption or disposition of, or containing any right of first refusal with respect
to, (4) requiring the registration for sale of, or (5) granting any preemptive or antidilutive
right with respect to, any Common Stock or any capital stock of, or other equity interests of, the
Company. Except as disclosed in the SEC Reports, there are no outstanding contractual obligations
of the Company or any subsidiary of the Company to provide material funds to, or make any material
investment (in the form of a loan, capital contribution or otherwise) in, any subsidiary of the
Company or any other person, other than guarantees by the Company of any indebtedness or other
obligations of any wholly-owned subsidiary of the Company.

(e) Validity of Shares. The Shares issued on the Closing Date, when issued, sold and delivered in
accordance with the terms and for the consideration set forth in this Agreement, shall be duly and
validly issued and outstanding, fully paid, nonassessable and free and clear of all security
interests, pledges, mortgages, liens, taxes, proxies, charges, adverse claims of ownership or use,
and restrictions, including preemptive rights, rights of first refusal and other similar rights,
restrictions on the resale, use, voting, receipt of income or other exercise of any attributes of
ownership and restrictions on transfer, defects of title or other encumbrance of any

 

			
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been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule
24b-2 of the Securities Exchange Act of 1934, as amended.

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kind or character entitling any person to purchase or acquire an ownership interest in any of such
Shares, other than restrictions on transfer set forth in this Agreement and under federal and state
securities laws.

(f) SEC Filings; Financial Statements.

     (i) The Company has timely filed all forms, reports and documents required to be filed by it
with the Securities and Exchange Commission (the “SEC”) and has heretofore made available
to Purchaser, in the form filed with the SEC, its: (1) most recent Annual Report on Form 10-K and
Quarterly Report on Form 10-Q; (2) most recent proxy statement for the annual meeting of
stockholders and (3) all Current Reports on Form 8-K filed with the SEC since the date of the
Company’s most recent report on Form 10-Q, if any (collectively, the “SEC Reports”). The
SEC Reports: (A) complied as to form in all material respects in accordance with the requirements
of the Exchange Act and (B) did not at the time they were filed contain any untrue statement of a
material fact or omit to state a material fact required to be stated therein or necessary in order
to make the statements therein, in light of the circumstances under which they were made, not
misleading. Except to the extent that information contained in any SEC Report has been updated,
revised, supplemented or amended by a later-filed SEC Report, none of the SEC Reports contains, as
of the Execution Date or as of the Closing Date, as applicable, an untrue statement of material
fact or omits to state a material fact required to be stated therein or necessary in order to make
the statements therein, in light of the circumstances under which they were made, not misleading.
As of the date of this Agreement, no subsidiary of the Company is subject to the reporting
requirements of the Exchange Act.

     (ii) Each of the financial statements (including, in each case, any notes thereto) contained
in the SEC Reports (collectively, the “Financial Statements”): (1) complied as to form in
all material respects with the published rules and regulations of the SEC applicable thereto; (2)
were prepared in accordance with generally accepted accounting principles applied on a consistent
basis throughout the periods covered (except as may be indicated in the notes to such financial
statements or, in the case of unaudited statements, as permitted by Form 10-Q of the SEC, and
except that the unaudited financial statements may not contain footnotes and are subject to normal
and recurring year-end adjustments that did not and will not, individually or in the aggregate, be
material in amount); and (3) fairly present the consolidated financial position of the Company as
of the respective dates thereof and the consolidated results of operations and cash flows of the
Company for the periods covered thereby. The books and records of the Company have been and are
being maintained in accordance with applicable material legal and accounting requirements. The
auditors who have certified the financial statements of the Company contained in the SEC Reports
are registered public accounting firms as required by the Securities Act and the Exchange Act and
the rules and regulations under the Securities Act and the Exchange Act. Except as disclosed in
the SEC Reports or set forth in the Financial Statements, and except for matters which are not,
individually or in the aggregate, reasonably expected to have a Material Adverse Effect, the
Company has no obligations or liabilities, whether or not accrued, contingent or otherwise and
whether or not required to be disclosed.

(g) Absence of Certain Changes. Except as disclosed in the SEC Reports, since June 30, 2009, there
has been no event, occurrence or development that has had or that would reasonably be expected to
result in a Material Adverse Effect, and the Company has not (i) varied its

 

			
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been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule
24b-2 of the Securities Exchange Act of 1934, as amended.

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business plan or practices, in any material respect, from past practices, (ii) entered into any
material financing, joint venture, license or similar arrangements or (iii) suffered or permitted
to be incurred any liability or obligation against any of its properties or assets that would limit
or restrict its ability to perform its obligations hereunder.

(h) Sarbanes-Oxley. There is and has been no failure on the part of the Company or any of the
Company’s directors or officers, in their capacities as such, to comply in all material respects
with any provision of the Sarbanes-Oxley Act of 2002 and the rules and regulations promulgated in
connection therewith (the “Sarbanes-Oxley Act”), including Section 402 related to loans and
Sections 302 and 906 related to certifications.

(i) Disclosure Controls. The Company maintains “disclosure controls and procedures” (as defined in
Rule 13a-15(e) of the Exchange Act) designed to ensure that information required to be disclosed by
the Company in reports that it files or submits under the Exchange Act is recorded, processed,
summarized and reported within the time periods specified in the SEC’s rules and forms. The
Company’s management (with the participation of its principal executive officer and the principal
financial officer) have evaluated the effectiveness of the Company’s disclosure controls and
procedures as of the end of the period covered by the Company’s Annual Report on Form 10-K for the
fiscal year ended December 31, 2008 and as of the end of the periods covered by the Company’s
Quarterly Reports on Form 10-Q for the periods ended March 31, 2009 and June 30, 2009, and its
principal executive officer and principal financial officer have concluded that such disclosure
controls and procedures are effective to ensure that information required to be disclosed by the
Company in reports that it files or submits under the Exchange Act is recorded, processed,
summarized and reported within the time periods specified in the rules and forms of the SEC.

(j) Internal Control Over Financial Reporting. The Company maintains “internal control over
financial reporting” (as defined in Rule 13a-15(f) of the Exchange Act) that complies with the
requirements of the Exchange Act and has been designed to provide reasonable assurance regarding
the reliability of financial reporting and the preparation of financial statements for external
purposes in accordance with generally accepted accounting principles. Except as disclosed in the
SEC Reports, there are no material weaknesses in the design or operation of the Company’s internal
control over financial reporting which are reasonably likely to adversely affect the Company’s
ability to record, process, summarize and report financial information that have come to the
attention of the Company’s management.

(k) Private Offering. Subject to the accuracy of Purchaser’s representations set forth in Section
4.1(c), Section 4.1(f) and Section 4.1(g), the offer, sale and issuance of the Shares in accordance
with the terms of this Agreement is in compliance with all applicable laws, exempt from the
registration requirements of Section 5 of the Securities Act and exempt from applicable state
registration or qualification requirements, other than those with which the Company has complied or
will comply.

(l) Subsidiaries. Except as disclosed in the SEC Reports, the Company does not presently own or
control, directly or indirectly, any interest in any other corporation, partnership, trust, joint
venture, association or other entity.

 

			
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been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule
24b-2 of the Securities Exchange Act of 1934, as amended.

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(m) Permits; Compliance With Law. The Company is in possession of all material authorizations,
licenses, permits, certificates, approvals and clearances, and has submitted notices to, all
governmental entities (including all authorizations under the Federal Food, Drug and Cosmetic Act
of 1938, as amended (the “FDCA”), and the regulations of the United States Food and Drug
Administration (the “FDA”) promulgated thereunder) necessary for the Company to own, lease
and operate its properties or other assets and to carry on its business in the manner described in
the SEC Reports (the “Company Permits”), and all such Company Permits are valid, and in
full force and effect, except where the failure to have, or the suspension or cancellation of, or
failure to be valid or in full force and effect of, any of the Company Permits would not,
individually or in the aggregate, reasonably be expected to have a Material Adverse Effect. The
Company is not in conflict with, or in default or violation of, (1) any federal, state, local or
foreign statute, law, ordinance, regulation, rule, code, order, judgment, writ, stipulation, award,
injunction, decree or arbitration award or finding or rule of common law applicable to the Company
or by which any property or asset of the Company is bound or affected, including, but not limited
to, rules and regulations promulgated by the FDA, laws, rules and regulations relating to the
protection of human health and safety, the environment or hazardous or toxic substances and the
Employee Retirement Income Security Act of 1974, as amended, including the regulations and
published interpretations thereunder (each of the foregoing collectively referred to as
“Law”) or (2) any Company Permits, except in the case of the foregoing (1) or (2) for any
such conflicts, defaults or violations that would not, individually or in the aggregate, reasonably
be expected to result in a Material Adverse Effect.

(n) Intellectual Property. The Company owns or possesses adequate rights or licenses to use all
material trademarks, trade names, service marks, service mark registrations, service names,
patents, patent rights, copyrights, inventions, licenses, approvals, governmental authorizations,
trade secrets and rights (the “Proprietary Rights”) necessary to conduct its business as
described in the SEC Reports, except where the failure to so own or possess such Proprietary Rights
will not, singularly or in the aggregate, have a Material Adverse Effect. The Company takes
commercially reasonable security measures to provide adequate trade secret protection in its
non-patented technology. Except as disclosed in the SEC Reports, the Company does not have any
knowledge of any infringement by the Company of any Proprietary Rights of others which could
reasonably be expected to result in a Material Adverse Effect, and, except as disclosed in the SEC
Reports, there is no claim, action or proceeding being made or brought against, or to the Company’s
knowledge, being threatened against, the Company regarding the infringement by the Company of the
Proprietary Rights of others that, if successful, could reasonably be expected to have a Material
Adverse Effect. Except as disclosed in the SEC Reports, the Company is not subject to any
judgment, order, writ, injunction or decree of any court or any Federal, state, local, foreign or
other governmental department, commission, board, bureau, agency or instrumentality, domestic or
foreign, or any arbitrator, nor, has it entered into or is a party to any contract which restricts
or impairs the use of any such Proprietary Rights in a manner which would have a Material Adverse
Effect. The Company has complied, in all material respects, with its respective contractual
obligations relating to the protection of the Proprietary Rights used pursuant to licenses, except
as would not have a Material Adverse Effect. Except as disclosed in the SEC Reports, to the
knowledge of the Company, no person is infringing on or violating the Proprietary Rights owned or
used by the Company in a manner that could reasonably be expected to have a Material Adverse
Effect.

 

			
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been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule
24b-2 of the Securities Exchange Act of 1934, as amended.

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(o) Environmental Laws. The Company (i) is in compliance with all applicable foreign federal,
state and local laws and regulations relating to the protection of human health and safety, the
environment or hazardous or toxic substances or wastes, pollutants or contaminants
(“Environmental Laws”), (ii) has received all permits, licenses or other approvals required
of them under applicable Environmental Laws to conduct its business and (iii) is in compliance with
all terms and conditions of any such permit, license or approval where, in each of the three
foregoing clauses, the failure to so comply would have, individually or in the aggregate, a
Material Adverse Effect.

(p) NASDAQ Compliance. The Common Stock is registered pursuant to Section 12(b) of the Exchange
Act and is listed on the NASDAQ Global Market, and the Company has taken no action designed to, or
likely to have the effect of, terminating the registration of the Common Stock under the Exchange
Act or delisting the Common Stock from the NASDAQ Global Market.

(q) Contracts. Except as disclosed in the SEC Reports and except for matters which are not
reasonably likely to have a Material Adverse Effect, the contracts listed as exhibits to the SEC
Reports that are material to the Company are in full force and effect, and neither the Company nor,
to the Company’s knowledge, any other party to such contracts is in material breach of or default
under any of such contracts.

(r) No Manipulation of Stock. The Company has not taken and will not, in violation of applicable
Law, take any action outside the ordinary course of business designed to or that might reasonably
be expected to cause or result in unlawful manipulation of the price of the Common Stock.

(s) Taxes. The Company has filed all federal, state and local income and franchise tax returns
required to be filed and has paid all taxes due thereon, and no tax deficiency has been determined
adversely to the Company which has had (nor does the Company have any knowledge of any tax
deficiency which, if determined adversely to the Company would reasonably be expected to have) a
Material Adverse Effect.

(t) Title to Assets. The Company has good title to or a valid leasehold interest in all of its
properties that are material to its business, in each case free and clear of any lien, charge,
claim, security interest, encumbrance, right of first refusal or other restriction
(“Liens”), except for (1) statutory liens not yet delinquent which are being contested in
good faith by appropriate proceedings, and liens for taxes not yet due, (2) pledges of assets in
the ordinary course of business to secure public deposits, (3) defects and irregularities of title
and encumbrances that do not materially impair the use thereof for the purposes for which they are
held, (4) mechanics’, materialmen’s, workmen’s, repairmen’s, warehousemen’s, carriers’ and other
similar liens arising in the ordinary course of business, (5) properties and assets the loss of
which would not, individually or in the aggregate, have a Material Adverse Effect, and (6) Liens
disclosed in the SEC Reports.

(u) Transfer Taxes. All stock transfer or other taxes (other than income taxes) which are required
to be paid in connection with the sale and transfer of the Shares to be sold to Purchaser

 

			
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been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule
24b-2 of the Securities Exchange Act of 1934, as amended.

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hereunder will be, or will have been, fully paid or provided for by the Company and all laws
imposing such taxes will be or will have been fully complied with.

(v) Transactions With Affiliates. No relationship, direct or indirect, exists between or among the
Company, on the one hand, and the directors, officers or stockholders of the Company, on the other
hand, which is required to be described in the SEC Reports which is not so described.

(w) No Brokers. The Company has taken no action which would give rise to any claim by any person
for brokerage commissions, finder’s fees or similar payments relating to this Agreement.

(x) Investment Company. The Company is not an “investment company” or an “affiliated person” of,
or “promoter” or “principal underwriter” for an investment company, within the meaning of the
Investment Company Act of 1940, as amended.

(y) Private Placement. Neither the Company nor any of its subsidiaries or affiliates, nor any
person acting on its or their behalf, (i) has engaged in any form of general solicitation or
general advertising (within the meaning of Regulation D under the Securities Act) in connection
with the offer or sale of the Common Stock, (ii) has, directly or indirectly, made any offers or
sales of any security or solicited any offers to buy any security, under any circumstances that
would require registration of the Shares under the Securities Act or (iii) has issued any shares of
Common Stock or shares of any series of preferred stock or other securities or instruments
convertible into, exchangeable for or otherwise entitling the holder thereof to acquire shares of
Common Stock which would be integrated with the sale of the Shares to Purchaser for purposes of the
Securities Act or of any applicable stockholder approval provisions, including, without limitation,
under the rules and regulations of any exchange or automated quotation system on which any of the
securities of the Company are listed or designated, nor will the Company or any of its subsidiaries
or affiliates take any action or steps that would require registration of any of the Shares under
the Securities Act or cause the offering of the Shares to be integrated with other offerings.
Assuming the accuracy of the representations and warranties of Purchaser, the offer and sale of the
Shares by the Company to Purchaser pursuant to this Agreement will be exempt from the registration
requirements of the Securities Act.

(z) Litigation. Except as disclosed in the SEC Reports, there is no legal action, suit,
arbitration or other legal, administrative, arbitration or governmental proceeding pending or, to
the Company’s knowledge, threatened against the Company that could reasonably be expected to have a
Material Adverse Effect.

(aa) Employees. Except as disclosed in the SEC Reports, (i) the Company is not aware that any
executive officer or key employee, or that any group of executive officers or key employees,
intends to terminate their employment with the Company, (ii) the Company does not have any present
intention to terminate the employment of any executive officer, key employee or group of key
employees and (iii) the Company is in compliance with all federal, state, local and foreign laws
and regulations respecting employment and employment practices, terms and conditions of employment
and wages and hours, in each case where such terminations or non-compliance could reasonably be
expected to have a Material Adverse Effect.

 

			
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been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule
24b-2 of the Securities Exchange Act of 1934, as amended.

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(bb) Application of Takeover Protections. There is no control share acquisition, business
combination, poison pill (including any distribution under a rights agreement) or other similar
anti-takeover provision under the Company’s charter documents or the laws of its state of
incorporation that is or could become applicable to Purchaser as a result of Purchaser and the
Company fulfilling their obligations or exercising their rights under this Agreement, including,
without limitation, as a result of the Company’s issuance of the Common Stock and Purchaser’s
ownership of the Common Stock.

(cc) Reporting Status; Eligibility to Use Form S-3. The Common Stock is registered under Section
12(b) of the Exchange Act. The Company currently meets the “registrant eligibility” requirements
set forth in the general instructions to Form S-3 to enable the registration of the Common Stock.

(dd) Disclosure. None of the representations or warranties of the Company contained herein and the
information contained in the Company Disclosure Schedule, when taken as a whole, contains any
untrue statement of a fact or omits to state a fact required to be stated herein or therein
necessary to make the statements herein or therein, in light of the circumstances under which they
were made, not misleading, except for facts which are disclosed in the SEC Reports or are not
reasonably likely to have a Material Adverse Effect.

4. REPRESENTATIONS AND WARRANTIES OF PURCHASER; RESTRICTIONS ON TRANSFER OF THE SHARES

4.1 Representations and Warranties. Purchaser hereby represents and warrants to the Company the
following:

(a) Authorization. All necessary corporate action on the part of Purchaser for the execution,
delivery and performance of its obligations under this Agreement and for the consummation of the
transactions contemplated hereby has been taken. This Agreement constitutes a valid and legally
binding obligation of Purchaser enforceable in accordance with its terms.

(b) Corporate Organization and Authority. Purchaser is a corporation duly organized, validly
existing, and in good standing under the laws of the State of Delaware. Purchaser has the
corporate power, authority and capacity to execute and deliver this Agreement and to perform its
obligations under this Agreement and any document contemplated to be delivered hereby.

(c) Purchase Entirely for Own Account. This Agreement is made with Purchaser in reliance upon
Purchaser’s representation to the Company, which by Purchaser’s execution of this Agreement
Purchaser hereby confirms, that the Shares to be purchased by Purchaser will be acquired for
investment for Purchaser’s own account, not as a nominee or agent, and not with a view to the
resale or distribution of any part thereof. Purchaser has no present intention of selling,
granting any participation in or otherwise distributing the same. By executing this Agreement,
Purchaser further represents that Purchaser does not presently have any contract, undertaking,
agreement or arrangement with any person to sell, transfer or grant participations to such person
or to any third person, with respect to any of the Shares and Purchaser has not been formed for the
specific purpose of acquiring the Shares.

 

			
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been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule
24b-2 of the Securities Exchange Act of 1934, as amended.

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(d) Restricted Securities. Purchaser understands that the Shares have not been, and will not be,
registered under the Securities Act, by reason of a specific exemption from the registration
provisions of the Securities Act, which depends upon, among other things, the bona fide nature of
the investment intent and the accuracy of Purchaser’s representations as expressed in Section
4.1(c). Purchaser understands that the Shares are “restricted securities” under applicable U.S.
federal and state securities laws and that, pursuant to these laws, Purchaser must hold the Shares
indefinitely unless they are registered with the SEC and qualified by state authorities, or an
exemption from such registration and qualification requirements is available. Purchaser further
acknowledges that if an exemption from registration or qualification is available, it may be
conditioned on various requirements including, but not limited to, the time and manner of sale, the
holding period for the Shares, and on requirements relating to the Company that are outside of
Purchaser’s control.

(e) Legend. Purchaser understands that the Shares may bear the following legend:

THESE SECURITIES HAVE NOT BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE
SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE
SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR
SOLD OR OTHERWISE TRANSFERRED, PLEDGED OR HYPOTHECATED EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION
STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION
NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE WITH
APPLICABLE STATE SECURITIES LAWS AS EVIDENCED BY A LEGAL OPINION OF COUNSEL TO THE TRANSFEROR TO
SUCH EFFECT, THE SUBSTANCE OF WHICH SHALL BE REASONABLY ACCEPTABLE TO THE COMPANY.

(f) Accredited Investor. Purchaser is an accredited investor as defined in Rule 501(a) of
Regulation D promulgated under the Securities Act.

(g) Investment Experience. Purchaser has such knowledge and experience in financial and business
matters that Purchaser is capable of evaluating the merits and risks of the investment in the
Shares.

(h) Trading in Company Common Stock. Since January 1, 2009, except pursuant to this Agreement,
neither Purchaser nor any affiliate of Purchaser has directly, or indirectly through an agent,
broker, financial advisor or other third party, sold, bought, made any short sale of, loaned,
granted or received any option for the purchase or sale of, or otherwise directly acquired or
disposed of any securities of the Company, whether on the NASDAQ Global Market or otherwise.

5. COVENANTS OF THE COMPANY

     The Company covenants and agrees with Purchaser that from and after the Execution Date:

 

			
	[ * ] =	 	Certain confidential information contained in this document, marked by brackets, has
been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule
24b-2 of the Securities Exchange Act of 1934, as amended.

108

 

5.1 Registration Rights.

(a) At any time after the date that is six (6) months after the Execution Date, upon the written
request of Purchaser, the Company shall prepare and file, as expeditiously as reasonably possible,
a registration statement under the Securities Act (“Registration Statement”) on Form S-3
(“Form S-3”) covering the resale of the Shares. In the event that Form S-3 is unavailable
for such a registration, then the Company will (i) file a Registration Statement on such form as is
then available to effect a registration of all of the Shares, and (ii) undertake to register the
Shares on Form S-3 as soon as such form is available, provided that the Company shall maintain the
effectiveness of the Registration Statement then in effect until such time as a Registration
Statement on Form S-3 covering the Shares has been declared effective by the SEC. The Company
shall use its reasonable best efforts to have the Registration Statement declared effective by the
SEC as soon as practicable. On the business day following the effective date of such Registration
Statement, the Company shall file with the SEC in accordance with Rule 424 under the Securities Act
the final prospectus to be used in connection with sales pursuant to such Registration Statement.
If for any reason the SEC does not permit all of the Shares to be included in such Registration
Statement, or for any other reason any Shares are not then included in a Registration Statement
filed pursuant to this Agreement, then the Company shall prepare, and, as soon as practicable, file
with the SEC an additional Registration Statement covering the resale of all Shares not already
covered by an existing and effective Registration Statement for an offering to be made on a
continuous basis pursuant to Rule 415. The Company shall use its reasonable best efforts to cause
each such Registration Statement to be declared effective under the Securities Act as soon as
possible. On the business day following the effective date of such Registration Statement, the
Company shall file with the SEC in accordance with Rule 424 under the Securities Act the final
prospectus to be used in connection with sales pursuant to such Registration Statement.

(b) If, at any time before October 17, 2015, the Company decides to register any of its securities
for its own account or for the account of others, then the Company will promptly give Purchaser
written notice thereof and will use its reasonable best efforts to include in such registration all
or any part of the Shares requested by Purchaser to be included therein. This requirement does not
apply to Company registrations on Form S-4 or S-8 or their equivalents relating to equity
securities to be issued solely in connection with an acquisition of any entity or business or
equity securities issuable in connection with stock option or other employee benefit plans.
Purchaser must give its request for registration under this paragraph to the Company in writing
within 15 days after receipt from the Company of notice of such pending registration. If the
registration for which the Company gives notice is an underwritten public offering, the Company
will so advise Purchaser as part of the above-described written notice. If the managing
underwriter of any proposed underwritten public offering advises the Company that the total amount
of shares of Common Stock that Purchaser and any other persons intend to include in such offering
exceeds the number that can be sold in such offering without being likely to have an adverse effect
on the price, timing or distribution of the Common Stock offered or the market for the Common
Stock, then the shares of Common Stock to be included in such underwritten offering shall include
the number of shares of Common Stock that such managing underwriter advises the Company can be sold
without having such adverse effect, with such number to be allocated (i) first, among the Company
and the investors who are party to that certain Amended and Restated Investor Rights Agreement,
dated July 13, 2004 (the “Existing IRA”), by and among the Company and the investors set
forth on Exhibit A thereto, pursuant to the terms thereof; (ii) second, to Purchaser; and (iii)
third, to any other person holding Company securities

 

			
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been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule
24b-2 of the Securities Exchange Act of 1934, as amended.

109

 

who may also be including any such securities for sale in such underwritten offering. No
registration rights that further limit or subordinate the rights of Purchaser to register the
Shares will be granted by the Company until one or more registration statements covering all of the
Shares have become effective.

(c) The Company will file all reports required to be filed by the Company with the SEC in a timely
manner so as to preserve its eligibility for the use of Form S-3.

5.2 Consents. The Company shall use its commercially reasonable efforts to procure, in a timely
manner upon reasonable terms and conditions, all consents and approvals, complete all filings,
registrations and certificates, and satisfy all other requirements prescribed by Law, which are
necessary to consummate the transactions contemplated in this Agreement prior to the Closing Date.

5.3 Cooperation. The Company shall cooperate fully, completely and promptly with Purchaser in
connection with satisfying all conditions to, and effecting the transactions contemplated by, this
Agreement.

5.4 Commercially Reasonable Efforts. The Company shall use its commercially reasonable efforts to
cause the conditions set forth in Sections 7.1 and 7.3 to be satisfied on or prior to the Closing
Date.

5.5 Further Assurances. The Company agrees to use its commercially reasonable efforts to take, or
cause to be taken, any appropriate action, and do, or cause to be done, all things necessary,
proper or advisable under any applicable Law to consummate and make effective the sale and
assignment of the Shares contemplated by this Agreement as promptly as practicable after the
Execution Date.

5.6 Operation of Business. The Company agrees prior to the Closing to (a) maintain its existence
in good standing under applicable Law, (b) conduct its operations in all material respects only in
the ordinary and usual course of business consistent with past practice and (c) not take any action
or establish a record date for the taking of any action with respect to any stock split, stock
dividend, combination of shares, recapitalization or other change in the structure of the Company
which affects or relates to the Common Stock.

5.7 Form D; Blue Sky Laws. The Company will timely file a Notice of Sale of Securities on Form D
with respect to the Shares, under Regulation D promulgated by the Commission under the Securities
Act. The Company will, on or before the Closing Date, take such action as it reasonably determines
to be necessary to qualify the Shares for sale to Purchaser under this Agreement under applicable
securities (or “blue sky”) laws of the states of the United States (or to obtain an exemption from
such qualification).

5.8 Issuance of Certificates. The Company will, or will instruct its transfer agent to, issue
certificates registered in the name of Purchaser or its nominee, for the Shares. All such
certificates will bear the restrictive legend described in Section 4.1(e), except as otherwise
specified in Section 5.9. The Company will not give to its transfer agent any instruction other
than as described in this Section 5.8 and Section 5.9 and stop transfer instructions to give effect
to Section 4.1(e) (prior to registration of the Shares under the Securities Act). Nothing in this

 

			
	[ * ] =	 	Certain confidential information contained in this document, marked by brackets, has
been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule
24b-2 of the Securities Exchange Act of 1934, as amended.

110

 

Section 5.8 and Section 5.9 affects in any way Purchaser’s obligation to comply with all applicable
prospectus delivery requirements, if any, upon resale of the Shares.

5.9 Unrestricted Securities. If, unless otherwise required by applicable state securities laws,
(a) the Shares represented by a certificate have been registered under an effective Registration
Statement, (b) Purchaser and/or its nominee provides the Company and its transfer agent with an
opinion of counsel, in form, substance and scope customary for opinions of counsel in comparable
transactions, to the effect that a public sale or transfer of such Shares may be made without
registration under the Securities Act and such sale may occur without restriction on the manner of
such sale or transfer, (c) such holder provides the Company and its transfer agent with reasonable
assurances that such Shares can be sold under Rule 144 promulgated by the SEC pursuant to the
Securities Act, as such Rule may be amended from time to time, or any similar rule or regulation
hereafter adopted by the SEC having substantially the same effect as such Rule (“Rule
144”), or (d) the Shares represented by a certificate can be sold without restriction as to the
number of securities sold under Rule 144, the Company will permit the transfer of the Shares, and
the Company will instruct its transfer agent to issue one or more certificates, free from any
restrictive legend, in such name and in such denominations as specified by such holder.
Notwithstanding anything herein to the contrary, the Shares may be pledged as collateral in
connection with a bona fide margin account or other lending arrangement; provided, that
such pledge will not alter the provisions of this Section 5.9 with respect to the removal of
restrictive legends.

6. COVENANTS OF PURCHASER

     Purchaser covenants and agrees with the Company that from and after the Execution Date:

6.1 Consents. Purchaser shall use its commercially reasonable efforts to procure, in a timely
manner upon reasonable terms and conditions, all consents and approvals, complete all filings,
registrations and certificates, and satisfy all other requirements prescribed by Law, which are
necessary to consummate the transactions contemplated in this Agreement.

6.2 Cooperation. Purchaser shall cooperate fully, completely and promptly with the Company in
connection with satisfying all conditions to, and effecting the transactions contemplated by, this
Agreement.

6.3 Commercially Reasonable Efforts. Purchaser shall use its commercially reasonable efforts to
cause the conditions set forth in Section 7.2 and Section 7.3 to be satisfied on or prior to the
Closing Date.

6.4 Further Assurances. Purchaser agrees to use its commercially reasonable efforts to take, or
cause to be taken, any appropriate action, and do, or cause to be done, all things necessary,
proper or advisable under any applicable Law to consummate and make effective the sale and
assignment of the Shares contemplated by this Agreement as promptly as practicable after the
Execution Date.

 

			
	[ * ] =	 	Certain confidential information contained in this document, marked by brackets, has
been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule
24b-2 of the Securities Exchange Act of 1934, as amended.

111

 

7. CLOSING CONDITIONS

7.1 Conditions to Obligations of Purchaser at Closing. At the Closing, the obligation of Purchaser
to purchase the Shares shall be subject to the satisfaction or Purchaser’s waiver, on or prior to
the Closing Date, of each of the following conditions:

(a) Each of the representations and warranties of the Company contained in this Agreement shall be
true and correct in all material respects.

(b) All covenants, agreements and conditions contained in this Agreement to be performed by the
Company on or prior to the Closing Date shall have been performed or complied with in all material
respects at or prior to the Closing Date. The Company shall have obtained any and all consents and
waivers necessary or appropriate for the consummation of the transactions contemplated by this
Agreement.

(c) Purchaser shall have received each of the documents to be delivered to it pursuant to Section
2.2(a).

(d) The Company shall have executed and delivered this Agreement and the Collaboration Agreement,
such agreements shall be in full force and effect.

(e) The holders of at least a majority of the shares of Common Stock that constitute Registrable
Securities (as defined in the Existing IRA) shall have consented to the Company granting to the
Purchaser the registration rights contained in Section 5.1 of this Agreement.

7.2 Conditions to Obligations of the Company at the Closing. At Closing, the obligation of the
Company to sell and issue the Shares shall be subject to the satisfaction or the Company’s waiver,
on or prior to the Closing Date, of each of the following conditions:

(a) Each of the representations and warranties of Purchaser contained in this Agreement shall be
true and correct in all material respects.

(b) All covenants, agreements and conditions contained in this Agreement to be performed by
Purchaser on or prior to the Closing Date shall have been performed or complied with in all
material respects at or prior to the Closing Date.

(c) The Company shall have received each of the documents to be delivered to it pursuant to Section
2.2(b).

(d) Purchaser shall have executed and delivered this Agreement and the Collaboration Agreement,
such agreements shall be in full force and effect.

(e) The holders of at least a majority of the shares of Common Stock that constitute Registrable
Securities shall have consented to the Company granting to the Purchaser the registration rights
contained in Section 5.1 of this Agreement.

7.3 Conditions to Obligations of Each Party. At the Closing, the obligation of Purchaser to
purchase the Shares and the obligation of the Company to sell and issue the Shares to be sold and

 

			
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been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule
24b-2 of the Securities Exchange Act of 1934, as amended.

112

 

issued at the Closing shall be subject to the satisfaction or waiver, on or prior to the Closing
Date, of each of the following conditions:

(a) All statutory requirements for the valid consummation by the Parties of the transactions
contemplated in this Agreement to be consummated at the Closing shall have been fulfilled, and all
consents, authorizations, permits, waivers and approvals (including of all U.S. federal, state and
local and non-U.S. governmental agencies and authorities) required to be obtained in order to
permit the consummation by Parties of the transactions contemplated by this Agreement to be
consummated at the Closing shall have been obtained.

(b) No action or claim shall be pending or threatened before any court or quasi-judicial or
administrative agency of any federal, state, local or foreign jurisdiction or before any arbitrator
wherein an unfavorable injunction, judgment, order, decree, ruling or charge would (i) prevent
consummation of any of the transactions contemplated by this Agreement, (ii) cause any of the
transactions contemplated by this Agreement to be rescinded following consummation or (iii) have
the effect of making illegal the purchase of, or payment for, any of the Shares by Purchaser.

(c) There shall be no temporary restraining order, preliminary injunction or permanent injunction
or other order preventing the consummation of the transaction contemplated by this Agreement to be
completed at the Closing issued by any court that remains in effect.

8. TERMINATION

8.1 Termination. This Agreement may be terminated:

(a) at any time by the mutual written consent of the Company and Purchaser;

(b) by the Company, on the one hand, or Purchaser, on the other hand, by written notice to the
other Party, if the Closing shall not have been consummated on or before September 18, 2009, unless
the failure to consummate the Closing on or prior to such date is the result of a default under
this Agreement by the Party seeking to terminate this Agreement pursuant to the terms of this
Section 8.1(b);

(c) at any time by Purchaser upon written notice to the Company if (i) the Company fails to perform
any of its covenants or agreements contained herein in any material respect and such breach shall
not have been cured within twenty (20) business days of the delivery of written notice by Purchaser
to the Company of such breach, or (ii) any of the conditions to Purchaser’s obligation to
consummate the transactions provided for herein shall have become impossible to satisfy;

(d) by the Company upon written notice to Purchaser if (i) Purchaser fails to perform any of its
covenants or agreements contained herein in any material respect and such breach shall not have
been cured within twenty (20) business days of the delivery of written notice by the Company to
Purchaser of such breach, or (ii) any of the conditions to the Company’s obligation to consummate
the transactions provided for herein shall have become impossible to satisfy; and

 

			
	[ * ] =	 	Certain confidential information contained in this document, marked by brackets, has
been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule
24b-2 of the Securities Exchange Act of 1934, as amended.

113

 

(e) by Purchaser or the Company (the “Terminating Party”) if (i) any proceeding seeking
liquidation, reorganization or other relief with respect to the other
Party under any bankruptcy, insolvency or other similar Law now or hereafter in effect has not been dismissed within sixty (60)
days after the commencement thereof, (ii) such other Party is adjudged as bankrupt or insolvent, or
a final and non-appealable order for relief under any bankruptcy, insolvency or other similar Law
now or hereafter in effect has been entered against such other Party, (iii) the other Party has
filed a voluntary petition under any bankruptcy, insolvency or other similar Law or under the
reorganization provisions of any such Law seeking liquidation, reorganization or other relief under
any bankruptcy, insolvency or other similar Law now or hereafter in effect, (iv) the other Party
executes and delivers a general assignment for the benefit of creditors, (v) the other Party seeks,
consents to or acquiesces in the appointment of a trustee, receiver or liquidator for such other
Party or for all or any substantial part of such other Party’s properties, (vi) the other Party
files an answer or other pleading admitting or failing to contest the material allegations of a
petition filed against such other Party in any proceeding of the nature described in clause (ii)
above, (vii) the other Party is unable to confirm in writing that it is, following a request by the
Terminating Party upon 48 hours notice (or otherwise indicates that it is not), able to pay its
debts as they mature, (viii) the appointment without the other Party’s consent or acquiescence of a
trustee, receiver or liquidator has not been vacated or stayed within ninety (90) days of such
appointment, or (ix) an appointment referred to in clause (viii) above is not vacated within ninety
(90) days after the expiration of any such stay.

8.2 Effect of Termination. In the event that this Agreement shall be terminated pursuant to
Section 8.1, all further obligations of the parties hereto under this Agreement (other than
pursuant to Section 10.9, which shall continue in full force and effect) shall terminate without
further liability or obligation of either Party to the other Party hereunder; provided that, no
Party shall be released from liability accrued hereunder prior to the date of termination.

9. SURVIVAL OF REPRESENTATIONS, WARRANTIES AND COVENANTS; INDEMNIFICATION

9.1 Survival. Each of the parties’ representations, warranties, covenants and agreements set forth
in this Agreement shall survive the Closing for the full applicable statute of limitations.

9.2 Indemnity by the Company. The Company shall indemnify and hold Purchaser and its affiliates
and its and their officers, directors and agents (the “Purchaser Indemnitees”) harmless
from and against, and shall pay to Purchaser the full amount of, any loss, claim, damage, liability
or expense (including reasonable attorneys’ fees) (hereafter referred to as a “Claim”)
resulting to a Purchaser Indemnitee from any inaccuracy in any representation or warranty as of the
Closing Date or any breach of any covenant or agreement, by the Company contained in this
Agreement.

9.3 Indemnity by Purchaser. Purchaser shall indemnify and hold the Company harmless from and
against, and shall pay to the Company and its affiliates and its and their officers, directors and
agents (the “Company Indemnitees”) the full amount of, any Claim resulting to a Company
Indemnitee from any inaccuracy in any representation or warranty, or any breach of any covenant or
agreement, by Purchaser contained in this Agreement.

 

			
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been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule
24b-2 of the Securities Exchange Act of 1934, as amended.

114

 

9.4 Remedies. Upon the occurrence of any event for which the Company or Purchaser is entitled
to indemnification under this Agreement, such party shall have all the rights and remedies in Law
and in equity available to it.

10. MISCELLANEOUS

10.1 Entire Agreement; Amendment. This Agreement constitutes the entire Agreement between the
Parties with respect to the within subject matter and supersedes all previous Agreements, whether
written or oral. This Agreement shall not be changed or modified orally, but only by an instrument
in writing signed by both Parties.

10.2 Governing Law; Choice of Law. This Agreement and the validity, performance, construction and
effect of this Agreement shall be governed in all respects by the laws of the State of Delaware,
excluding its provisions governing the conflict of laws.

10.3 Assignment. This Agreement may not be assigned by either Party without the prior written
consent of the other, except that, (a) Purchaser may assign this Agreement to an “affiliate” (as
such term is defined in Rule 501(b) of Regulation D promulgated under the Securities Act) of
Purchaser and (b) the Company may assign this Agreement to a party that acquires all or
substantially all of the Company’s business, whether by merger, sale of assets or otherwise. A
merger, consolidation or other reorganization shall be deemed to constitute an assignment. Any
assignment in contravention of this Section 10.3 shall be void.

10.4 Notices. Any notices required or permitted hereunder shall be given to the appropriate Party
at the address specified below or at such other address as the Party shall specify in writing.
Such notice shall be in writing sent by: (i) certified mail, postage prepaid, return receipt
requested; (ii) nationally recognized courier service; or (iii) facsimile. Notice shall be deemed
given (a) if sent by certified mail, on the earlier of the date the return receipt is signed or on
the third business day (fifth business day if sent internationally) after the notice is mailed;
(b) if sent by nationally recognized courier service, on the day the notice is delivered according
to the records of such courier service; or (c) if sent by facsimile, upon the date such notice is
transmitted by facsimile, provided that such transmission is subsequently confirmed by a hard copy
sent by nationally recognized courier service within twenty-four (24) hours of the transmission.

For Company: 

Facet Biotech Corporation

1500 Seaport Blvd.

Redwood City, CA 94063

Attn: General Counsel

Facsimile: (650) 454-2000

with a copy to:

Cooley Godward Kronish LLP

Five Palo Alto Square

3000 El Camino Real

Palo Alto, CA 94306-2155

Attn: Glen Sato

 

			
	[ * ] = 	 	Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

115

 

Facsimile: (650) 849-7400

For Purchaser: 

Trubion Pharmaceuticals, Inc.

2401 4th Avenue

Suite 1050

Seattle, WA 98121

Attn: General Counsel

Facsimile: (206) 838-0503

with a copy to:

Fenwick & West LLP

1191 Second Avenue

10th Floor

Seattle, WA 98101

Attn: Alan C. Smith

Facsimile: (206) 389-4511

10.5 Waiver. The failure of either Party to assert a right hereunder or to insist upon compliance
with any term or condition of this Agreement shall not constitute a waiver of that right or excuse
a similar subsequent failure to perform any such term or condition by the other Party. None of the
terms, covenants and conditions of this Agreement can be waived except by the written consent of
the Party waiving compliance.

10.6 No Third-Party Beneficiary. This Agreement is for the benefit of, and may be enforced only
by, the Company and Purchaser and their respective successors and permitted transferees and
assignees, and is not for the benefit of, and may not be enforced by, any third party.

10.7 Finder’s Fees.

          (a) The Company hereby agrees to indemnify and to hold Purchaser and its affiliates and agents
harmless from and against any costs, expenses or liability for any commission or compensation in
the nature of a finder’s fee to any investment banker, finder, broker or other person or firm
(including legal fees and other costs and expense of defending against such liability or asserted
liability) resulting from or arising out of acts or alleged acts of the Company, its affiliates or
its or their representatives.

          (b) Purchaser (i) represents and warrants that it has retained no investment bankers, finders
or brokers in connection with the transactions contemplated by this Agreement and (ii) hereby
agrees to indemnify and hold the Company harmless from and against any costs, expenses or liability
for any commission or compensation in the nature of a finder’s fee to any investment banker,
finder, broker or other person or firm (including legal fees and other costs and expense of
defending against such liability or asserted liability) resulting from or arising out of acts or
alleged acts of Purchaser, its affiliates or its or their representatives.

10.8 Expenses. The Company and Purchaser shall each bear its respective expenses and legal fees
incurred with respect to the negotiation, execution, delivery and performance of this Agreement and
the transactions contemplated hereby.

 

			
	[ * ] =  	 	Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

116

 

10.9 Counterparts. This Agreement may be executed in counterparts, all of which taken together
shall be regarded as one and the same instrument. Execution and delivery of this Agreement by
exchange of facsimile copies bearing the facsimile signature of a Party hereto shall constitute a
valid and binding execution and delivery of this Agreement by such Party. Such facsimile copies
shall constitute enforceable original documents.

10.10 Severability. If any provision of this Agreement is declared invalid by a court of last
resort or by any court from the decision of which an appeal is not taken within the time provided
by Law, then and in such event, this Agreement will be deemed to have been terminated only as to
the portion thereof that relates to the provision invalidated by that decision, but this Agreement,
in all other respects will remain in force; provided, however, that if the provision so invalidated
is essential to this Agreement as a whole, then the Parties shall negotiate in good faith to amend
the terms of this Agreement as nearly as practical to carry out the original intent of the Parties.

10.11 Time of the Essence. Time is of the essence for purposes of this Agreement.

10.12 Rules of Interpretation. Within this Agreement (a) a reference to any individual, firm,
trust, corporation, partnership, limited liability company, governmental entity or business
organization includes such entity’s permitted successors and permitted assigns; (b) the words
“include,” “includes” and “including” are not limiting; (c) references to any document, instrument
or agreement (i) shall include all exhibits, schedules and other attachments thereto, (ii) shall
include all documents, instruments or agreements issued or executed in replacement thereof, and
(iii) shall mean such document, instrument or agreement, or replacement thereof, as amended,
modified and supplemented from time to time and in effect at any given time; (d) the words
“hereof,” “herein” and “hereunder” and words of similar import when used shall refer to this
Agreement as a whole and not to any particular provision of this Agreement; and (e) the headings
used in this Agreement have been inserted for convenience only, and they are not intended to be a
part of or to affect the meaning or interpretation of this Agreement.

(Signature page follows.)

 

			
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brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

117

 

     IN WITNESS WHEREOF, the Parties have executed this Agreement by their duly authorized
representatives as of the Execution Date.

	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	Company:	 	 	 	Purchaser:
	 
	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	Trubion Pharmaceuticals, Inc.	 	 	 	Facet Biotech Corporation
	 
	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	By:

	 	 	 	 	 	By:	 	 	 	 	 	 	 	 
	 

	 	Peter A. Thompson, M.D., FACP  
	 	 	 	 	 	 
	 	 	 	 	 	 
	 

	 	President and Chief Executive Officer
	 	 	 	 	 	 
	 	 	 	 	 	 
	 

	 	
	 	 	 	 	 	 
	 	 	 	 	 	 

 

			
	[ * ] =  	 	Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

118

 

Schedule 1.132 (Trubion Core Patent Rights)

	 	 	 	 	 	 	 	 	 
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	 	[ * ]

 

			
	[ * ] =  	 	Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

119

 

	 	 	 	 	 	 	 	 	 
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	[ * ] =  	 	Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

120

 

	 	 	 	 	 	 	 	 	 
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	[ * ] =  	 	Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

121

 

	 	 	 	 	 	 	 	 	 
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	[ * ] =  	 	Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

122

 

Schedule 1.134 (Trubion Product Patent Rights)

	 	 	 	 	 	 	 	 	 
	TRBN Ref.	 	Country	 	 	 	App / Patent No.	 	Status
	 
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	[ * ] =  	 	Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

123

 

Schedule 3.7 (Pre-existing Obligations)

	 	•	 	[ * ] Manufacturing Services Agreement, dated [ * ], as amended [ * ] and [ * ]

	 	•	 	[ * ] Research Evaluation Agreement, dated [ * ], as amended [ * ]

	 	•	 	[ * ] Supply Agreement, dated [ * ]

	 	•	 	[ * ] Services Agreement dated [ * ]

	 	•	 	[ * ] Quality Agreement, dated [ * ]

	 	•	 	[ * ] Development and Manufacturing Services Agreement, dated [ * ], as amended [ * ]
and [ * ], and [ * ] dated [ * ].

	 	•	 	[ * ] Services Agreement, dated [ * ] and [ * ] (the “[ * ]”) [ * ] to the [ * ] dated [
* ] and [ * ] to the [ * ] dated [ * ].

	 	•	 	[ * ] Services Agreement dated [ * ] as amended [ * ]

	 	•	 	[ * ] Services Agreement dated [ * ], including [ * ] Agreement dated [ * ] (the “[ *
]”), [ * ] to the [ * ] dated [ * ]

	 	•	 	[ * ] Supply

	 	•	 	[ * ] Purchase Order [ * ]

	 	•	 	[ * ] Service Agreement dated [ * ]

	 	•	 	[ * ] Laboratory Services Agreement dated [ * ] and amended

	 	•	 	[ * ] Exemplar Quotes [ * ] and [ * ]

	 	•	 	[ * ] Agreement, dated [ * ] and [ * ] dated [ * ] and [ * ] dated [ * ]

	 	•	 	[ * ] Services Agreement dated [ * ] and [ * ]

	 	•	 	[ * ] Consulting Agreement dated [ * ]

	 	•	 	[ * ] Consulting Agreement dated [ * ]

	 	•	 	[ * ] Consulting Services Agreement dated [ * ]

	 	•	 	[ * ] Consulting Services Agreement dated [ * ]

	 	•	 	[ * ] Consulting Services Agreement dated [ * ]

	 	•	 	[ * ] Consulting Services Agreement dated [ * ]

	 	•	 	[ * ] Consulting Agreement dated [ * ]

	 	•	 	[ * ] Consulting Services Agreement dated [ * ] as amended by Amendment No. 1 dated [ *
]

	 	•	 	[ * ] Consulting Services Agreement dated [ * ] as amended [ * ]

	 	•	 	[ * ] Consulting Services Agreement dated [ * ]

	 	•	 	[ * ] Consulting Agreement dated [ * ]

	 	•	 	[ * ] Consulting Agreement dated [ * ]

	 	•	 	[ * ] Consulting Services Agreement dated [ * ]

	 	•	 	[ * ] Consulting Services Agreement dated [ * ]

	 	•	 	[ * ] Consulting Services Agreement dated [ * ]

	 	•	 	[ * ] Clinical Trial Agreement dated [ * ] as amended [ * ] and [ * ]

	 	•	 	[ * ] and [ * ] Clinical Trial Agreement dated [ * ] as amended [ * ]

	 	•	 	[ * ] Clinical Trial Agreement dated [ * ], 2008] as amended [ * ]

	 	•	 	[ * ] dated [ * ] as amended [ * ]

	 	•	 	[ * ] Clinical Trial Agreement dated [ * ]

	 	•	 	[ * ] Clinical Trial Agreement dated [ * ]

 

			
	[ * ] =  	 	Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

124

 

Schedule 12.2 (Disclosure Schedule) 

[ * ]

	 	•	 	[ * ] Research Evaluation Agreement, dated [ * ], as amended [ * ] (subject to the [ * ]
of [ * ] under [ * ])

	 	•	 	[ * ] Manufacturing Services Agreement, dated [ * ], as amended [ * ] and [ * ] (subject
to the [ * ] of [ * ] under Section [ * ])

	 	•	 	[ * ] Material Transfer Agreement dated [ * ]

	 	•	 	[ * ] Supply Agreement, dated [ * ]

	 	•	 	[ * ] Development and Manufacturing Services Agreement, dated [ * ], as amended [ * ]
and [ * ] (subject to the [ * ] of [ * ] under Section [ * ])

	 	•	 	[ * ] Services Agreement dated [ * ], including [ * ] dated [ * ] (the “[ * ]”), [ * ]
to the [ * ] dated [ * ] and [ * ] – [ * ] under [ * ]

	 	•	 	[ * ] Consulting Agreement dated [ * ]

	 	•	 	[ * ] Consulting Agreement dated [ * ] as amended [ * ]

[ * ]

	 	•	 	[ * ] Material Transfer Agreement dated [ * ], as amended [ * ], [ * ] and [ * ]

	 	•	 	[ * ] Amended and Restated Material Transfer Agreement dated [ * ]

	 	•	 	[ * ] Services Agreement dated [ * ]

	 	•	 	[ * ] License Agreement dated [ * ]

	[ * ]   [ * ] has [ * ] to [ * ] or other [ * ] from the [ * ]:

          [ * ] ([ * ] and [ * ])

          [ * ] ([ * ] and [ * ])

          [ * ], on [ * ] ([ * ])

[ * ]

[ * ] Reference is made to the disclosure under subsection [ * ] of this Schedule 12.2.

 

			
	[ * ] = 	 	 Certain confidential information contained in this document, marked by
brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

125

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