Document:

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                                                                     Exhibit 4.4

THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES
ACT OF 1933, AS AMENDED (THE "SECURITIES ACT"), OR ANY STATE SECURITIES LAW. NO
TRANSFER OF THESE SECURITIES SHALL BE VALID OR EFFECTIVE UNLESS (A) SUCH
TRANSFER IS MADE PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE
SECURITIES ACT AND IN COMPLIANCE WITH ANY APPLICABLE STATE SECURITIES LAWS, OR
(B) THE COMPANY HAS RECEIVED AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO
THE COMPANY THAT SUCH TRANSFER QUALIFIES AS AN EXEMPT TRANSACTION UNDER THE
SECURITIES ACT AND ANY APPLICABLE STATE SECURITIES LAWS.

Warrant No. __                           Date of Original Issuance: May 11, 2004
                                                Date of Amendment: July 19, 2006

              AMENDED AND RESTATED WARRANT TO PURCHASE COMMON STOCK
                                       OF
                              ALFACELL CORPORATION

                Void after 5:00 P.M. (United States Eastern Time)
                       on May 9, 2009, as provided herein.

     This certifies that, for value received, receipt and sufficiency of which
are hereby acknowledged, KNOLL CAPITAL FUND II, or its registered assigns (the
"HOLDER"), is entitled, subject to the terms and conditions set forth below, to
purchase from ALFACELL CORPORATION, a Delaware corporation (the "COMPANY"),
592,500 (the "WARRANT NUMBER") validly issued, fully paid and nonassessable
shares (the "WARRANT SHARES") of Common Stock of the Company, par value $0.001
per share (the "COMMON STOCK"), subject to adjustment as provided herein, at a
purchase price equal to $2.88 per share (the "EXERCISE PRICE"), subject to
adjustment as provided herein.

     The term "WARRANT" as used herein shall mean this Warrant, and any warrants
delivered in substitution or exchange therefor as provided herein.

     1. Definitions. In addition to the terms defined elsewhere in this Warrant,
capitalized terms that are not otherwise defined herein shall have the meanings
given to such terms in the Securities Purchase Agreement dated as of May 11,
2004 to which the Company and the original Holder are parties.

     2. Term of Warrant. Subject to the terms and conditions set forth herein,
this Warrant shall be exercisable, in whole or in part, during the term
commencing on January __,

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2007 [six months from the Closing Date as such term is defined in the Securities
Purchase Agreement dated July 17, 2006 among the Company and the Purchasers
identified therein] and ending at 5:00 P.M. (United States Eastern Time) on May
9, 2009 (the "EXERCISE PERIOD").

     3. Exercise of Warrant.

          (a) This Warrant may be exercised by the Holder, in whole or in part,
by (i) the surrender of this Warrant to the Company, with the Notice of Exercise
annexed hereto duly completed and executed on behalf of the Holder, at the
office of the Company (or such other office or agency of the Company as it may
designate by notice in writing to the Holder at the address of the Holder
appearing on the books of the Company) during the Exercise Period and (ii) the
delivery of payment to the Company of the Exercise Price for the number of
Warrant Shares specified in the Notice of Exercise in cash or its equivalent,
payable by wire transfer of immediately available funds to a bank account
specified by the Company or by certified or bank cashiers' check in lawful money
of the United States of America.

          (b) Cashless Exercise. In the event a registration statement covering
the resale of the Warrant Shares has not been declared effective or has been
suspended by the Securities and Exchange Commission or the prospectus forming a
part thereof is not then available to the Holder for the resale of the Warrant
Shares, then the Holder may notify the Company in an Exercise Notice of its
election to utilize cashless exercise, in which event the Company shall issue to
the Holder the number of Warrant Shares determined as follows:

                      X = Y [(A-B)/A]

               where:

                      X = the number of Warrant Shares to be issued to the
                      Holder.

                      Y = the number of Warrant Shares with respect to which
                      this Warrant is being exercised.

                      A = the average of the closing prices for the five Trading
                      Days immediately prior to (but not including) the
                      Exercise Date.

                      B = the Exercise Price.

For purposes of Rule 144 promulgated under the Securities Act, it is intended,
understood and acknowledged that the Warrant Shares issued in a cashless
exercise transaction shall be deemed to have been acquired by the Holder, and
the holding period for the Warrant Shares shall be deemed to have commenced, on
the date this Warrant was originally issued.

          (c) The Company agrees that such Warrant Shares shall be deemed to be
issued to the Holder as the record holder of such Warrant Shares as of the close
of business on the date on which this Warrant shall have been surrendered and
payment made for the Warrant Shares as aforesaid. A stock certificate or
certificates for the Warrant Shares specified in the Notice of Exercise shall be
delivered to the Holder as promptly as practicable, and in any event

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within ten Business Days thereafter. If this Warrant shall have been exercised
only in part, the Company shall, at the time of delivery of the stock
certificate or certificates, deliver to the Holder a new Warrant evidencing the
rights to purchase the remaining Warrant Shares, which new Warrant shall in all
other respects be identical with this Warrant. No adjustments shall be made on
Warrant Shares issuable on the exercise of this Warrant for any cash dividends
paid or payable to holders of record of Common Stock prior to the date as of
which the Holder shall be deemed to be the record holder of such Warrant Shares.
For purposes of this Warrant, the term "BUSINESS DAY" shall mean any day except
a Saturday, Sunday or any day on which banking institutions are authorized or
required to close in the city of New York, New York.

     4. No Fractional Shares or Scrip. No fractional shares or scrip
representing fractional shares shall be issued upon the exercise of this
Warrant. In lieu of any fractional share to which the Holder would otherwise be
entitled, the Company shall make a cash payment equal to the Current Market
Price multiplied by such fraction. For the purpose of this Section 3, the
"CURRENT MARKET PRICE" per share of Common Stock on any day shall be deemed to
be the average of the closing price per share reported for the five Business
Days immediately preceding the day in question, where the closing price for each
day shall be the reported last sale price regular way or, in case no such
reported sale takes place on such day, the average of the reported closing bid
and asked prices regular way, in either case on the New York Stock Exchange or,
if the Common Stock is not listed or admitted to trading on such Exchange, on
the principal national securities exchange on which the Common Stock is listed
or admitted to trading or, if not listed or admitted to trading on any national
securities exchange, on the Nasdaq National Market System or, if the Common
Stock is not listed or admitted to trading on any national securities exchange
or quoted on the Nasdaq National Market System, the average of the closing bid
and asked prices in the over-the-counter market as furnished by any New York
Stock Exchange member firm reasonably selected from time to time by the board of
directors of the Company for that purpose.

     5. Replacement of Warrant. On receipt of evidence reasonably satisfactory
to the Company of the loss, theft, destruction or mutilation of this Warrant
and, in the case of loss, theft or destruction, on delivery of an indemnity
agreement reasonably satisfactory in form and substance to the Company or, in
the case of mutilation, on surrender and cancellation of this Warrant, the
Company at its expense shall execute and deliver, in lieu of this Warrant, a new
warrant of like tenor and amount.

     6. Rights of Stockholders. Subject to the provisions of Sections 7 and 9
hereof, the Holder shall not be entitled to vote or receive dividends or be
deemed the holder of Common Stock or any other securities of the Company that
may at any time be issuable on the exercise hereof for any purpose, nor shall
anything contained herein be construed to confer upon the Holder, as such, any
of the rights of a stockholder of the Company or any right to vote for the
election of directors or upon any matter submitted to stockholders at any
meeting thereof, or to give or withhold consent to any corporate action (whether
upon any recapitalization, issuance of stock, reclassification of stock, change
of par value, or change of stock to no par value, consolidation, merger,
conveyance or otherwise) or to receive notice of meetings, or to receive
dividends or subscription rights or otherwise until the Warrant shall have been
exercised, and the Exercise Price shall have been paid, as provided herein.

                                      -3-

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     7. Antidilution Provisions. The Exercise Price and the Warrant Number shall
be subject to adjustment from time to time as provided in this Section 7.

          (a) In case the Company shall pay or make a dividend or other
distribution on the Common Stock of the Company in Common Stock (other than any
distributions specifically provided for in subsection (c) of this Section 7),
the Exercise Price in effect immediately prior to the opening of business on the
next Business Day following the date fixed for determination of stockholders
entitled to receive such dividend or other distribution shall be reduced by
multiplying such Exercise Price by a fraction of which (i) the numerator shall
be the number of shares of Common Stock outstanding at the close of business on
the date fixed for such determination and (ii) the denominator shall be the sum
of (A) such number of shares referred to in clause (i) and (B) the total number
of shares of Common Stock constituting such dividend or other distribution, such
reduction to become effective immediately prior to the opening of business on
the next Business Day following the date fixed for such determination. For the
purposes of this subsection (a), the number of shares of Common Stock at any
time outstanding shall include shares issuable in respect of scrip certificates
issued in lieu of fractions of shares of Common Stock.

          (b) In case the outstanding shares of Common Stock shall be subdivided
into a greater number of shares of Common Stock, the Exercise Price in effect
immediately prior to the opening of business on the next Business Day following
the day upon which such subdivision becomes effective shall be proportionately
reduced, and, conversely, in case the outstanding shares of Common Stock shall
each be combined into a smaller number of shares of Common Stock, the Exercise
Price in effect immediately prior to the opening of business on the next
Business Day following the day upon which such combination becomes effective
shall be proportionately increased.

          (c) In case the Company shall, by dividend or otherwise, distribute to
all holders of its Common Stock any securities (including any security
convertible into or exchangeable for shares of Common Stock and any right,
option or warrant to subscribe for or purchase shares of Common Stock or any
other security convertible into or exchangeable for shares of Common Stock, but
not including any dividend referred to in subsection (a) of this Section 7),
evidences of its indebtedness or other assets, then, in each such event and as a
condition precedent to the taking of any such action, lawful and adequate
provision (satisfactory in form and substance to the Holder and without payment
of any additional consideration therefor) shall be made whereby the Holder shall
thereafter have the right to receive, upon exercise of this Warrant, in addition
to the number of shares of Common Stock receivable thereupon, the amount of such
securities, evidences of indebtedness or other assets as the Holder would have
received had the Holder been the record owner, at the time the Company made or
issued such dividend or other distribution or on the record date fixed therefor,
as the case may be, of that number of shares of Common Stock receivable upon
exercise of this Warrant in full, and had the Holder thereafter, during the
period from the date of such event to and including the date(s) on which the
Holder exercises this Warrant, retained such securities, evidences of
indebtedness or other assets, giving application to all other adjustments called
for during such period under this Section 7. The above provisions of this
subsection (c) shall similarly apply to

                                      -4-

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successive dividends and other distributions to the holders of Common Stock of
securities, evidences of indebtedness and other assets.

          (d) In case of any reclassification, recapitalization or other change
in the outstanding securities of the class issuable upon exercise of this
Warrant (including any such reclassification, recapitalization or other change
upon a merger or consolidation in which the Company is the surviving
corporation, but not including any transactions for which an adjustment is
provided in subsection (a), (b), (c) or (e) of this Section 7), the Company
shall execute and deliver to the Holder a new warrant certificate, satisfactory
in form and substance to the Holder and without payment of any additional
consideration therefor, providing that the Holder shall have the right
thereafter, during the period such Warrant shall be outstanding, to exercise
such Warrant into the kind and amount of securities, cash and other property
receivable upon such reclassification, recapitalization or other change by a
holder of the number of shares of Common Stock issuable upon exercise of this
Warrant had it been exercised immediately prior to such reclassification,
recapitalization or other change. Such new Warrant shall provide for adjustments
that, for events subsequent to the effective date of such new Warrant, shall be
as nearly equivalent as may be practicable to the adjustments provided for in
this Section 7. The above provisions of this subsection (d) shall similarly
apply to successive reclassifications, recapitalizations and other changes in
the outstanding securities of the class issuable upon exercise of this Warrant.

          (e) In case of any merger or consolidation of the Company with or
into, or sale or transfer of all or substantially all of the assets of the
Company to, any other person or entity, the person or entity surviving such
merger or consolidation or acquiring such assets, as the case may be, shall
execute and deliver to the Holder a new warrant certificate, satisfactory in
form and substance to the Holder and without payment of any additional
consideration therefor, providing that the Holder shall have the right
thereafter, during the period such Warrant shall be outstanding, to exercise
such Warrant into the kind and amount of securities, cash and other property
receivable upon such merger, consolidation, sale or transfer by a holder of the
number of shares of Common Stock issuable upon exercise of this Warrant had it
been exercised immediately prior to such merger, consolidation, sale or
transfer. If the holders of the Common Stock may elect from choices the kind or
amount of securities, cash and other property receivable upon such merger,
consolidation, sale or transfer, then for the purpose of this Section 7 the kind
and amount of securities, cash and other property receivable upon such merger,
consolidation, sale or transfer shall be deemed to be the choice specified by
the Holder, which specification shall be made by the Holder by the later of (i)
the lesser of (A) the number of days given to holders of Common Stock to make
their specification known to the Company after such holders are provided with a
final version of all information that was furnished to such holders concerning
such choice or (B) ten Business Days after the Holder is provided with a final
version of all information that was furnished to the holders of Common Stock
concerning such choice, and (ii) the last time at which holders of Common Stock
are permitted to make their specification known to the Company. If the Holder
fails to make any specification, the Holder's choice shall be deemed to be
whatever choice is made by a plurality of holders of Common Stock not affiliated
with the Company or the other person to the merger, consolidation, sale or
transfer. Such new Warrant shall provide for adjustments that, for events
subsequent to the effective date of such new Warrant, shall be as nearly
equivalent as may be practicable to the adjustments

                                      -5-

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provided for in this Section 7. The above provisions of this subsection (e)
shall similarly apply to successive mergers, consolidations, sales or transfers.

          (f) Whenever there shall be any change in the Exercise Price under
this Section 7, then there shall be an adjustment (to the nearest thousandth of
a share) in the Warrant Number, which adjustment shall become effective at the
time such change in the Exercise Price becomes effective and shall be made by
multiplying the Warrant Number in effect immediately before such change in the
Exercise Price by a fraction the numerator of which is the Exercise Price
immediately before such change and the denominator of which is the Exercise
Price immediately after such change.

          (g) No adjustment in the Exercise Price shall be required unless such
adjustment (plus any adjustments not previously made by reason of this
subsection (g)) would require an increase or decrease of at least 1% in such
Exercise Price; provided, however, that any adjustments that by reason of this
subsection (g) are not required to be made shall be carried forward and taken
into account in any subsequent adjustment. All calculations under this
subsection (g) shall be made to the nearest cent or to the nearest 1/100 of a
share of Common Stock, as the case may be. Notwithstanding the foregoing, any
adjustment required by this subsection (g) shall be made no later than the
expiration of the right to exercise the Warrant or a portion thereof.

          (h) Whenever the Exercise Price is adjusted as herein provided:

               (i) the Company shall compute the adjusted Exercise Price in
accordance with Section 7 and shall prepare a certificate signed by the Chief
Financial Officer of the Company setting forth the adjusted Exercise Price and
showing in reasonable detail the facts upon which such adjustment is based, and
such certificate shall forthwith be filed with any transfer agent; and

               (ii) a notice stating that the Exercise Price has been adjusted
and setting forth the adjusted Exercise Price shall forthwith be required, and
as soon as practicable after it is required, such notice (together with a copy
of the certificate prepared under Section 7(h)(i) hereof) shall be mailed by the
Company to the Holder of the Warrant at its last address as shall appear in the
Warrant Register (as defined in Section 8(a)).

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          (i) In case the Company shall declare a dividend (other than a cash
dividend) or other distribution on its Common Stock, or shall take a record of
the holders of Common Stock for the purpose of determining the holders thereof
who are entitled to receive any such dividend or other distribution, the Company
shall cause to be filed with any warrant agent, and shall cause to be mailed to
the Holder of this Warrant at its last address as shall appear in the Warrant
Register, at least ten days prior to the effective date hereinafter specified, a
notice stating the date on which a record has been taken for the purpose of such
dividend or other distribution or, if record is not to be taken, the date as of
which the identity of the holders of Common Stock of record entitled to such
dividend or other distribution is to be determined. Neither the failure to give
such notice nor any defect therein shall affect the legality or validity of the
proceedings described in this subsection (i).

     8. Transfer of Warrant.

          (a) Warrant Register. The Company will maintain a register (the
"WARRANT REGISTER") containing the names and addresses of the Holder or Holders.
Any Holder of this Warrant or any portion thereof may change his, her or its
address as shown on the Warrant Register or transfer this Warrant in accordance
with the terms of this Warrant by written notice to the Company requesting such
change. Any notice or written communication required or permitted to be given to
the Holder may be delivered or given by mail to such Holder as shown on the
Warrant Register and at the address shown on the Warrant Register. Until receipt
by the Company of written notice from the Holder requesting a change of address
or the transfer of this Warrant, the Company may treat the Holder as shown on
the Warrant Register as the absolute owner of this Warrant for all purposes.
This Amended and Restated Warrant replaces the warrant (Warrant No. 230) to
purchase 592,500 shares of the Company's Common Stock issued to the Original
Holder on May 11, 2004. By accepting this Warrant, the Holder agrees that the
Old Warrant shall have been terminated as of July 19, 2006 and be of no further
force or effect as of such date.

          (b) Warrant Agent. The Company may, by written notice to the Holder,
appoint an agent for the purpose of maintaining the Warrant Register referred to
in subsection (a) of this Section 8, issuing the Common Stock or other
securities then issuable upon the exercise of this Warrant, exchanging this
Warrant, replacing this Warrant, or any or all of the foregoing. Thereafter, any
such registration, issuance, exchange, or replacement, as the case may be, shall
be made at the office of such agent.

          (c) Transferability. Subject to the restrictions on transfer set forth
in subsection (d) of this Section 8, title to this Warrant may be transferred,
in whole or in part, by endorsement (by the Holder and the transferee executing
the Assignment Form annexed hereto) and delivery in the same manner as a
negotiable instrument transferred by endorsement and delivery. Upon surrender of
this Warrant for transfer, properly endorsed on the Assignment Form, the Company
at its expense shall issue, on the order of the Holder, a new warrant or
warrants of like tenor, in such name or names as the Holder (on payment by the
Holder of any applicable transfer taxes) may direct, for the number of shares
issuable upon exercise hereof. Each Holder of this Warrant, by holding it,
agrees that this Warrant, when endorsed in blank, may be deemed negotiable, and
that, when this Warrant shall have been so endorsed, the Holder

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<PAGE>

of this Warrant may be treated by the Company and all other persons dealing with
this Warrant as the absolute owner of this Warrant for any purpose and as the
person entitled to exercise the rights represented by this Warrant, or to the
transfer of this Warrant on the books of the Company, any notice to the contrary
notwithstanding.

          (d) Compliance with Securities Laws.

               (i) The Holder of this Warrant, by acceptance hereof,
acknowledges that the transfer of this Warrant and the Warrant Shares is subject
to the Holder's compliance with the provisions of the Securities Act and any
applicable state securities laws in respect of any such transfer.

               (ii) The certificate or certificates representing any Warrant
Shares acquired upon exercise of this Warrant, and any Common Stock or other
securities issued in respect of such Warrant Shares upon any stock split, stock
dividend, recapitalization, merger, consolidation or similar event, shall be
stamped or otherwise imprinted with the following legend (unless such a legend
is no longer required under the Securities Act):

     THE TRANSACTION IN WHICH THE SHARES REPRESENTED BY THIS CERTIFICATE WERE
     ACQUIRED WAS NOT REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED
     (THE "SECURITIES ACT"), OR ANY STATE SECURITIES LAW. NO TRANSFER OF THE
     SHARES REPRESENTED BY THIS CERTIFICATE SHALL BE VALID OR EFFECTIVE UNLESS
     (A) SUCH TRANSFER IS MADE PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT
     UNDER THE SECURITIES ACT AND IN COMPLIANCE WITH ANY APPLICABLE STATE
     SECURITIES LAWS, OR (B) THE COMPANY HAS RECEIVED AN OPINION OF COUNSEL
     REASONABLY SATISFACTORY TO THE COMPANY THAT SUCH TRANSFER QUALIFIES AS AN
     EXEMPT TRANSACTION UNDER THE SECURITIES ACT AND ANY APPLICABLE STATE
     SECURITIES LAWS.

               (iii) The Company shall not be required to register the transfer
of this Warrant or the Warrant Shares on the books of the Company unless the
Company shall have been provided with an opinion of counsel in form and
substance reasonably satisfactory to the Company that this Warrant or the
Warrant Shares, as applicable, are eligible for transfer without registration
under the Securities Act; provided, however, that no such opinion of counsel
shall be necessary in order to effectuate a transfer of this Warrant or any of
the Warrant Shares (A) in accordance with the provisions of Rule 144(k)
promulgated under the Securities Act after removal of the legend set forth in
Section 8(d)(ii) or (B) with respect to the Warrant Shares, in accordance with
the intended method of disposition set forth in the registration statement to be
filed by the Company pursuant to that certain Registration Rights Agreement
dated as of May 10, 2004 by and among the Company, the initial holder of this
Warrant and certain other purchasers of the Company's Common Stock (the
"REGISTRATION RIGHTS AGREEMENT") or any other registration statement filed by
the Company and covering the Warrant Shares.

               (iv) The conditions precedent imposed by this subsection (d) upon
the transferability of this Warrant and the Warrant Shares shall cease and
terminate as to this

                                      -8-

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Warrant and any of the Warrant Shares (A) when such securities shall have been
registered under the Securities Act and sold or otherwise disposed of in
accordance with the intended method of disposition by the seller or sellers
thereof set forth in the registration statement covering such securities, (B) at
such time as the Company shall have been provided with an opinion of counsel in
form and substance reasonably satisfactory to the Company to the effect that the
restrictive legend on such securities is no longer required in order to
establish compliance with the provisions of the Securities Act, or (C) when such
securities are transferred pursuant to Rule 144 or in accordance with the
provisions of Rule 144(k) promulgated under the Securities Act. Whenever the
conditions imposed by this subsection (d) shall terminate as hereinabove
provided with respect to any of the Warrant Shares, the holder of any such
securities bearing the legend set forth in Section 8(d)(ii) shall be entitled to
receive from the Company, without expense (except for the payment of any
applicable transfer taxes) and as expeditiously as practicable, new stock
certificates not bearing such legend.

          (e) Investment Representations. The Holder of this Warrant, by
acceptance hereof, acknowledges that this Warrant is being issued by the Company
in reliance upon the following representations:

               (i) the Holder is an "accredited investor" within the meaning of
Rule 501 of Regulation D under the Securities Act as presently in effect;

               (ii) this Warrant is being acquired, and upon exercise hereof the
Warrant Shares will be acquired, for investment, for the Holder's own account
and not with a view to the sale or distribution thereof other than in accordance
with the Securities Act and all applicable state securities laws, and the Holder
has no present intention of selling or engaging in any public distribution of
the same except pursuant to a registration under the Securities Act or an
exemption therefrom; and

               (iii) the Holder has such knowledge and experience in financial
and business matters as to be capable of evaluating the merits and risks of its
investment and has the ability to bear the economic risks of its investment.

     9. Covenants of the Company. The Company hereby covenants and agrees that:

          (a) during the term of this Warrant, the Company will reserve a
sufficient number of shares of authorized and unissued Common Stock to provide
for the issuance of Common Stock upon the exercise of this Warrant and the
payment of the Exercise Price, which shares shall be duly authorized, fully paid
and non-assessable, and, from time to time, will take all steps necessary to
amend its Certificate of Incorporation to provide sufficient reserves of shares
of Common Stock issuable upon exercise of the Warrant;

          (b) the Company will not, by amendment of its Certificate of
Incorporation or through reorganization, consolidation, merger, dissolution or
sale of assets, or by any other voluntary act, avoid or seek to avoid the
observance or performance of any of the covenants, stipulations or conditions to
be observed or performed hereunder by the Company;

                                      -9-

<PAGE>

          (c) all Warrant Shares shall, upon exercise of this Warrant and
payment of the Exercise Price as set forth herein, be free from all taxes, liens
and charges in respect of the issue thereof (other than taxes in respect of any
transfer occurring contemporaneously or otherwise specified herein); and

          (d) all Warrant Shares shall, upon issuance, be listed on the
securities exchange or quotation system on which the Common Stock is then listed
or quoted.

     10. Registration Rights.

The initial Holder of this Warrant (and certain assignees thereof) is entitled
to the benefit of such registration rights in respect of the Warrant Shares as
are set forth in the Registration Rights Agreement, including the right to
assign such rights to certain assignees, as set forth therein.

     11. Amendments. Neither this Warrant nor any term hereof may be amended,
waived, discharged or terminated other than by a written instrument signed by
the party against whom enforcement of any such amendment, waiver, discharge or
termination is sought.

     12. Governing Law. This Warrant shall be governed in all respects by the
internal laws of the State of Delaware as applied to contracts entered into
solely between residents of, and to be performed entirely within, such state,
and without reference to principles of conflicts of laws or choice of laws.

     13. Successors and Assigns. This Warrant shall be binding upon the
Company's successors and assigns and shall inure to the benefit of the Holder's
successors, legal representatives and permitted assigns.

     14. Attorney's Fees. In the event of a dispute with regard to the
interpretation of this Warrant, the prevailing party may collect the cost of
reasonable attorney's fees, litigation expenses or such other expenses as may be
incurred in the enforcement of the prevailing party's rights hereunder.

                                      -10-

<PAGE>

     IN WITNESS WHEREOF, ALFACELL CORPORATION has caused this Warrant to be
executed by its authorized officer.

     Dated: July 17, 2006

                                        ALFACELL CORPORATION

                                        By:
                                            ------------------------------------
                                        Name:
                                              ----------------------------------
                                        Title:
                                               ---------------------------------

<PAGE>

                               NOTICE OF EXERCISE

To: ALFACELL CORPORATION

     (1) The undersigned hereby elects to purchase _______________ shares of
Common Stock of Alfacell Corporation, pursuant to the terms of the attached
Warrant, and tenders herewith payment of the purchase price for such shares in
full, or, in the alternative, has indicated below an intention to exercise this
warrant through a cashless exercise in accordance with Section 2(b), and has
indicated below the related exercise calculations in accordance with Section
2(b): _________________________________________________________

     (2) In exercising this Warrant, the undersigned hereby confirms and
acknowledges that the shares of Common Stock to be issued upon exercise are
being acquired solely for the account of the undersigned, and not as a nominee
for any other party, and for investment purposes, and that the undersigned will
not offer, sell or otherwise dispose of any such shares of Common Stock except
under circumstances that will not result in a violation of the registration
provisions of the Securities Act of 1933, as amended, or any applicable state
securities laws.

     (3) Please issue a certificate or certificates representing said shares of
Common Stock in the name of the undersigned or in such other name as is
specified below:

                                        ----------------------------------------
                                                         (Name)

                                        ----------------------------------------
                                                         (Name)

     (4) Please issue a new Warrant for the unexercised portion of the attached
Warrant in the name of the undersigned or in such other name as is specified
below:

                                        ----------------------------------------
                                                         (Name)

-------------------------------------   ----------------------------------------
(Date)                                                 (Signature)

<PAGE>

                                 ASSIGNMENT FORM

     FOR VALUE RECEIVED, the undersigned registered owner of this Warrant hereby
sells, assigns and transfers unto the Assignee named below all of the rights of
the undersigned under the within Warrant, with respect to the number of shares
of Common Stock set forth below:

<TABLE>
<CAPTION>
                              No of
Name of Assignee   Address   Shares
----------------   -------   ------
<S>                <C>       <C>

</TABLE>

and does hereby irrevocably constitute and appoint as Attorney ________________
to make such transfer on the books of ALFACELL CORPORATION, maintained for the
purpose, with full power of substitution in the premises.

     The undersigned Assignee represents that, by acceptance hereof, the
Assignee acknowledges and agrees that (i) this Warrant and the shares of stock
to be issued upon exercise hereof are being acquired for investment, (ii) the
Assignee will not offer, sell or otherwise dispose of this Warrant or any shares
of stock to be issued upon exercise hereof except under circumstances that will
not result in a violation of the registration provisions of the Securities Act
of 1933, as amended, or any applicable state securities laws, and (iii) the
Assignee agrees to be bound by all of the provisions of this Warrant.

Dated:
       -----------------------------

                                        ----------------------------------------
                                                   Signature of Holder

                                        ----------------------------------------
                                                  Signature of Assignee<PAGE>

                                                                     Exhibit 4.5

                           AGREEMENT TO AMEND WARRANT

     This Agreement is dated as of July 17, 2006, by and between SF Capital
Partners, Ltd. ("SF Capital") and Alfacell Corporation (the "Company").

     The undersigned hereby agree as follows:

     1. In connection with the Securities Purchase Agreement (the "Purchase
Agreement") dated as of the date hereof by and among the Company and the
purchasers of securities (the "Purchasers") that are a party thereto (including
affiliates of SF Capital), the Company and SF Capital have agreed to amend the
terms of a warrant to purchase 189,585 shares of the Company's common stock held
by SF Capital (the "Original Warrant").

     2. The Original Warrant shall be amended to reflect the following:

          -    The exercise price per share of Company common stock will be
               reduced to $2.88 per share.

          -    The Warrant will not be exercisable until six months from the
               Closing Date (as defined in the Purchase Agreement).

          Otherwise, the terms of the Original Warrant shall remain the same.

     3. On the Closing Date, The Company will issue a new warrant to SF Capital
to reflect the amended terms (the "Amended Warrant"). SF Capital shall return
the Original Warrant to the Company as soon as practicable and upon receipt, it
will be cancelled and destroyed. In the event SF Capital does not return the
Original Warrant to the Company, it shall be deemed cancelled; and, provided
further, that whether or not the Original Warrant is returned, the books and
records of the Company shall be updated to reflect the cancellation of the
Original Warrant and the issuance of the Amended Warrant.

     4. SF Capital acknowledges that the terms of the Purchase Agreement and
this Agreement will be disclosed on a Form 8-K to be filed by the Company (the
"8-K"). SF Capital consents to the disclosure of such terms, including the
identification of SF Capital as a Purchaser in the 8-K.

<PAGE>

     IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of
the day and year first above written.

                                        SF CAPITAL PARTNERS, LTD.

                                        By:
                                            ------------------------------------
                                        Name:
                                              ----------------------------------
                                        Its:
                                             -----------------------------------

AGREED AND ACCEPTED:

ALFACELL CORPORATION

By: /s/ Kuslima Shogen
    ---------------------------------
Name: Kuslima Shogen
Its: Chief Executive Officer

                                        2

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