Document:

Unassociated Document

Exhibit
10-17

First
Amendment to Restated Partial Requirements Agreement

Among

Metropolitan
Edison Company, Pennsylvania Electric Company, and

FirstEnergy
Solutions Corp.

This First
Amendment to the Restated Partial Requirements Agreement dated January 1, 2003
("Restated Agreement") is entered into by and among Metropolitan Edison Company,
a Pennsylvania corporation, Pennsylvania Electric Company, a Pennsylvania
corporation, on behalf of itself and The Waverly Electric Power and Light
Company, a New York corporation (collectively "Buyers"), and FirstEnergy
Solutions Corp. ("Seller"), an Ohio corporation, on this 29th day of August,
2003. Buyers and Seller are all wholly owned subsidiaries of FirstEnergy Corp.,
a registered public utility holding company. The Buyers and Sellers may be
individually referred to as a "Party" or collectively as "Parties;". Unless specifically modified herein, all terms
and conditions of the Restated Agreement remain in full force and effect. All
capitalized terms have the same meaning as in the Restated
Agreement.

WHEREAS the Parties
desire to amend their respective rights and obligations under the Restated
Agreement to permit Buyers to obtain all or a portion of their Provider of Last
Resort Obligation directly from third party suppliers where it is economic and
reasonable to do so;

NOW THEREFORE, in
consideration of the mutual agreements, covenants and conditions herein
contained, and for other good and valuable consideration, the receipt and
sufficiency of which is hereby acknowledged, and intending to be legally bound,
Buyers and Sellers agree as follows:

 

	 	
            1.
	
      Notwithstanding
      any provision of the Restated Agreement, the Parties agree that where
      economic and reasonable to do so, Buyers may purchase all or a portion of
      capacity, energy, ancillary services and other services necessary to
      satisfy their Provider of Last Resort Obligation for which Committed
      Resources have not been obtained from parties other than Seller. Seller
      may act as agent for Buyer in procuring the capacity, energy, ancillary
      services, and other services necessary to satisfy Buyers Provider of Last
      Resort Obligation. Buyers authorize Seller to act as agent for Buyers and
      to enter into any agreements as are reasonably necessary to obtain the
      capacity, energy, ancillary services, and other services necessary to
      satisfy this Provider of Last Resort Obligation on Buyers'
      behalf.

	 	 	 
	 	
           
      2.
	
      Buyers will
      be responsible for all costs of the capacity, energy, ancillary services,
      and other services acquired by Seller on their behalf. Seller will charge
      no fee or commission for providing this service to Buyers.
  

 

 

 

 

IN
WITNESS WHEREOF, this First Amendment has been executed and delivered by the
duly authorized officers of the Parties as of August 29, 2003.

	 FirstEnergy
      Solutions Corp. 	 	 	 
	
       

       

       

      By:/s/ Guy L.
      Pipitone
	 	 	
	
      

      Guy L. Pipitone, Senior Vice President	 	 	
	    	 	 	

 

Metropolitan
Edison Company

Pennsylvania
Electric Company

The Waverly
Electric Power and Light Company

	 	 	 	 
	By: /s/
      Richard H. Marsh	 	 	
	
      

      Richard
      H. Marsh, Senior Vice President	 	 	
		 	 	

 

 

 

 

 

56701

2

 

[Execution
Copy]

Restated
Partial Requirements Agreement

Among

Metropolitan
Edison Company, Pennsylvania Electric Company, and
FirstEnergy

Solutions
Corp.

This Restated
Partial Requirements Agreement ("Restated Agreement") dated as January 1,2003,
is entered into by and between Metropolitan Edison Company, a Pennsylvania
corporation, Pennsylvania Electric Company, a Pennsylvania corporation, on
behalf of itself and The Waverly Electric Power and Light Company, a New York
corporation (collectively "Buyers"), and FirstEnergy Solutions Corp. ("Seller"),
an Ohio corporation, all wholly owned subsidiaries of FirstEnergy Corp., a
registered utility holding company. The Buyers and Sellers may individually be
referred to as a "Party" or collectively as "Parties" in this Restated
Agreement.

WHEREAS, Buyers are
electric distribution companies with an obligation to serve retail customers
under New York and Pennsylvania law (hereinafter "Provider of Last Resort
Obligation"); and

WHEREAS, Seller is
authorized to sell wholesale capacity, energy, and ancillary services to Buyers
under First Revised Service Agreement Nos. 1 and 2 pursuant to Solutions FERC
Electric Tariff, Original Volume No.1; and

WHEREAS, Buyers
desire to obtain the wholesale capacity, energy and ancillary services necessary
to satisfy their retail Provider of Last Resort Obligation from
Seller

WHEREAS, the
Parties desire to restate their obligations under their Partial Requirements
Agreement dated September 1, 2002;

 

NOW THEREFORE, in
consideration of the mutual agreements, covenants and conditions herein
contained, and for other good and valuable consideration, the receipt and
sufficiency of which is hereby acknowledged, and intending to be legally bound,
Buyers and Seller hereby agree as follows:

	1.  	
      Purchase.
      Buyers agree to purchase from Seller the portion of their Provider of Last
      Resort Obligation for which committed capacity, energy and ancillary
      services resources ("Committed Resources") have not been obtained as of
      the date of this Restated Agreement. For purposes of this Restated
      Agreement, Committed Resources include, but are not limited to,
      non-utility generation under contract to Buyers, Buyer owned generating
      facilities, purchased power contracts, and distributed
      generation.

 

 

3

 

 

 

 

 

	2.  	
      Sale.
      Seller agrees to supply all capacity, energy and ancillary services
      required to meet the Buyers' Provider of Last Resort Obligation, less any
      Committed Resources, and will comply with all requirements of the Federal
      Energy Regulatory Commission, the New York Public Service Commission, the
      Pennsylvania Public Utility Commission, and the applicable requirements of
      PJM Interconnection, LLC.

	3.  	
      Forecast
      of Provider of Last Resort Obligation and Committed Resources. 
      No later than sixty days prior to the beginning of any calendar year,
      Buyers shall provide Seller a forecast ("Annual Forecast") of their
      Provider of Last Resort Obligation and Committed Resources for that
      calendar year. The capacity, energy, and ancillary services requirements
      associated with the Provider of Last Resort Obligation and Committed
      Resources for each month of that Annual Forecast will be provided in the
      format and detail agreed upon by the Parties. Buyers will update the
      Annual Forecast on a monthly basis for known changes. Buyers will change
      the amount of Provider of Last Resort Obligation or Committed Resources
      for any month of the Annual Forecast by written notice to Seller no later
      than five business days prior to the beginning of that month. Seller will
      be responsible for supplying all capacity, energy, and ancillary services
      required by Buyers' Provider of Last Resort customers regardless of the
      Annual Forecast supplied by Buyers.

	4.  	
      Transmission
      and Delivery Points. Seller will provide capacity, energy, and
      ancillary services, including losses, to Buyers at their respective zones
      within PJM. Title to capacity, energy, and ancillary services will pass to
      Buyers at the delivery points.

	 	
       5.
	
      Price for
      Provider of Last Resort Service. Metropolitan Edison Company and
      Pennsylvania Electric Company will pay Seller $41.65 and $41.41 per MWH,
      respectively for all capacity, energy, and ancillary services provided to
      Buyers under Section 1 of this Restated Agreement. The Parties will agree
      upon a transfer date for the funds remitted to Seller that will be no less
      frequently than monthly.

	
      
	
       6.
	
      Effective
      Date and Term. This Restated Agreement shall be effective January
      1,2003 and will remain in effect until December 31,2003. This initial term
      will be automatically extended for successive periods of one year unless
      either Party gives sixty days notice of termination to the other Party
      prior to the end of the calendar year. Unless otherwise agreed by the
      Parties, such termination shall not affect or excuse the performance of
      transactions entered into on behalf of either Party prior to notice of
      termination. This Restated Agreement shall remain in effect until both
      Parties have fully performed their obligations under said
      transactions.

	
      
	
       7.
	
      Regulatory
      Out Provision. In the event that a Party's obligations under this
      Restated Agreement are materially and adversely affected by a change in
      law, rule, regulation, or other action by a governmental authority or
      regulatory agency, the adversely affected Party may terminate this
      Restated Agreement upon sixty days written notice to the other
      Party.

4

 

	
       
	
        
      8.
	
      Governing
      Law. This Restated Agreement shall be governed by and construed in
      accordance with the laws of the Commonwealth of Pennsylvania without
      regard to the choice of law rules thereof.

 

 

	9.  	
      Execution
      in Counterparts; Facsimile Signatures. This Restated Agreement may be
      executed in multiple counterparts, each of which shall be considered an
      original instrument, but all of which shall be considered one and the same
      agreement, and shall become binding when all counterparts have been signed
      by each of the Parties and delivered to each Party hereto. Deli very of an
      executed signature page counterpart by telecopies shall be as effective as
      delivery of a manually executed
counterpart.

	10.  	
      Representation
      and Warranties. Each Party represents and warrants that it has full
      authority and right to enter into this Restated
  Agreement.

	11.  	
      Effect of
      Restated Agreement. This Restated Agreement supercedes and replaces
      all prior agreements between the Parties with respect to the subject
      matter hereof, including the September 1, 2002 Partial Requirements
      Agreement.

 

 

IN
WITNESS WHEREOF, this Restated Agreement has been executed and delivered by the
duly authorized officers of the Parties as of the date first above
written.

	 FirstEnergy
      Solutions Corp.	 	 	 
		 	 	
	
       

      By:
      /s/
      Arthur R. Garfield
      

      
 Arthur R.
      Garfield, President	 	 	
		 	 	

Metropolitan
Edison Company 

Pennsylvania
Electric Company

The Waverly
Electric Power and Light Company

 

	 	 	 	 
	 	 	 	
	
      By: /s/ H
      Peter Burg
      

      

           H. Peter Burg, President
	 	 	
		 	 	

 

Date:   
March 28, 2003

 

 

cc:  L.
Vespoli, A. Garfield, H. Wagner, 

      
D. Blank, W. Byrd, R. D' Angelo. 

      
R. Fields, K. Kolich, E. Ogden

From:   M.
Beiting

5

Partial
Requirements Agreement 

Among

Metropolitan
Edison Company, Pennsylvania Electric Company, and
FirstEnergy

Solutions
Corp.

This Partial
Requirements Agreement ("Agreement") dated as of September 1, 2002, is entered
into by and between Metropolitan Edison Company, a Pennsylvania corporation,
Pennsylvania Electric Company, a Pennsylvania corporation, on behalf of itself
and The Waverly Power and Light Company, a New York corporation (collectively
"Buyers"), and FirstEnergy Solutions Corp. ("Seller"), an Ohio corporation, all
wholly owned subsidiaries of FirstEnergy Corp., a registered utility holding
company. The Buyers and Sellers may individually be referred to as a "Party" or
collectively as "Parties" in this Agreement.

WHEREAS, Buyers are
electric distribution companies with an obligation to serve retail customers
under New York and Pennsylvania law (hereinafter "Provider of Last Resort
Obligation"); and

WHEREAS, Seller is
authorized to sell wholesale capacity, energy, and ancillary services to Buyers
under First Revised Service Agreement Nos. 1 and 2 pursuant to Solutions FERC
Electric Tariff, Original Volume No.1; and 

WHEREAS, Buyers
desire to obtain the wholesale capacity, energy and ancillary services necessary
to satisfy their retail Provider of Last Resort Obligation from
Seller;

NOW THEREFORE, in
consideration of the mutual agreements, covenants and conditions herein
contained, and for other good and valuable consideration, the receipt and
sufficiency of which is hereby acknowledged, and intending to be legally bound,
Buyers and Seller hereby agree as follows:

 

	 	
         
      1.
	
      Purchase.
      Buyers agree to purchase from Seller the portion of their Provider of Last
      Resort Obligation for which committed capacity, energy and ancillary
      services resources ("Committed Resources") have not been obtained as of
      the date of this Agreement. For purposes of this Agreement, Committed
      Resources include, but are not limited to, non-utility generation under
      contract to Buyers, Buyer owned generating facilities, purchased power
      contracts, and distributed generation under contract to
      Buyers.

 

	 	
        
      2.
	
      Sale.
      Seller agrees to supply all capacity, energy and ancillary services
      required to meet the Buyers'. Provider of Last Resort Obligation, less any
      Committed Resources, and will comply with all requirements of the Federal
      Energy Regulatory Commission, the New York Public Service Commission, the
      Pennsylvania Public Utility Commission, and the applicable requirements of
      PJM Interconnection, LLC.

 

6

	 	
         
      3.
	
      Forecast
      of Provider of Last Resort Obligation and Committed Resources. No
      later than five business days after the effective date of this Agreement,
      and no later than sixty days prior to the beginning of any subsequent
      calendar year, Buyers shall provide Seller a forecast ("Annual Forecast")
      of their Provider of Last Resort Obligation and Committed Resources for
      that calendar year. The capacity, energy, and ancillary services
      requirements associated with the Provider of Last Resort Obligation and
      Committed Resources for each month of that Annual Forecast will be
      provided in the format and detail agreed upon by the Parties. Buyers will
      update the Annual Forecast on a monthly basis for known changes. Seller
      will be responsible for supplying all capacity, energy, and ancillary
      services required by Buyers' Provider of Last Resort customers regardless
      of the accuracy of the Annual Forecast supplied by
  Buyers.

 

	 	
         
      4.
	
      Transmission
      and Delivery Points. Seller will provide capacity, energy, and
      ancillary services, including losses, to Buyers at their respective
      Transmission Zones within PIM. Title to capacity, energy, and ancillary
      services will pass to Buyers at the delivery
points.

 

	 	
         
      5.
	
      Compensation
      for Provider of Last Resort Service. Seller will provide capacity,
      energy, and ancillary services to Buyers, and Buyers will remit to Seller
      all amounts collected from retail customers for Provider of Last Resort
      generation service under their respective retail tariffs, less: 1) any
      revenue based taxes paid by Buyers; 2) Buyers' cost of Committed
      Resources; 3) generation-related PJM costs incurred by Buyers as a direct
      result of their Provider of Last Resort Obligation; and 4) an amount to be
      calculated by multiplying the rate determined in Schedule A by the actual
      monthly sales supplied by Seller. The Parties will agree upon a transfer
      date for the funds remitted to Seller that will be no less frequently than
      monthly.

	 	 	 
	 	 	 
	 	
         
      6.
	
      Effect of
      Commonwealth Court decision. If the decision in ARRIPA v.
      Pennsylvania Public Utility Commission, et al., 792 A.2d 636 (2002)
      becomes final or is affirmed with respect to the lack of authority under
      Pennsylvania law for Metropolitan Edison Company and Pennsylvania Electric
      Company to record deferred Provider of Last Resort Obligations on their
      books, Buyer may not continue to reduce the shopping credit by application
      of item 4) in paragraph 5 of this Agreement, and any prior reductions to
      the shopping credit revenue from application of item 4) will be remitted
      to Seller.

	 	
         
      7.
	
      Effective
      Date and Term. This Agreement shall be effective September 1, 2002 and
      will remain in effect until December 31,2002. This initial term will be
      automatically extended for successive periods of one year unless either
      Party gives at least sixty days notice of termination to the other Party
      prior to the end of the calendar year. Unless otherwise agreed by the
      Parties, such termination shall not affect or excuse the performance of
      transactions entered into or incurred on behalf of either Party prior to
      notice of termination. This Agreement shall remain in effect until both
      Parties have fully performed said transactions and
      obligations.

 

 

 

 

7

 

 

	 	
        
       8.
	
      Regulatory
      Out Provision. In the event that a Party's obligations under this
      Agreement are materially and adversely affected by a change in law, rule,
      regulation; or other action by a governmental authority or regulatory
      agency, the adversely affected Party may terminate this Agreement upon
      sixty days written notice to the other
Party.

 

 

	 	
         
      9.
	
      Governing
      Law. This Agreement shall be governed by and construed in accordance
      with the laws of the Commonwealth of Pennsylvania without regard to the
      choice of law rules thereof.

	 	
         
      10.
	
      Execution
      in Counterparts; Facsimile Signatures. This Agreement may be executed
      in multiple counterparts, each of which shall be considered an original
      instrument, but all of which shall be considered one and the same
      agreement, and shall become binding when all counterparts have been signed
      by each of the Parties and delivered to each Party hereto. Delivery of an
      executed signature page counterpart by telecopies shall be as effective as
      delivery of a manually executed counterpart.

	 	 	 
	 	 	 
	 	
         
      11.
	
      Representation
      and Warranties. Each Party represents and warrants that it has full
      authority and right to enter into this
Agreement.

	 	
         
      12.
	
      General.
      This Agreement constitutes the entire agreement of the Parties relating to
      the subject matter and revokes and supercedes any previous agreement of
      the Parties related to the subject matter. No amendment or modification to
      this Agreement will be enforceable unless reduced to writing and executed
      by both Parties.

 

 

IN WITNESS WHEREOF,
this Agreement has been executed and delivered by the duly authorized officers
of the Parties as of August 30, 2002.

 

 

	 FirstEnergy
      Solutions Corp.	 	 	
      Metropolitan
      Edison Company

      Pennsylvania
      Electric Company

      The Waverly
      Power and Light Company

	
       

       

       

      By:/s/ Guy L.
      Pipitone
	 	
        

       

         

                      
      
	
       

       

       

      By: /s/ H.
      Peter Burg

	
      
      

             Guy L. Pipitone

           
      Senior Vice President
	 	 	
      
      

            H. Peter Burg,

            
      President

		 	 	

 

(53237)

 

 

 

 

8

 

 

 

Schedule
A

 

 

As a condition of
this Agreement, beginning in 2003 Buyers will reduce the shopping credit by the
following calculation.

 

     
rate = [BALBOP * (Mp / Mf)] / GWHf

     
Pay Down Amount = rate* sales supplied by Seller for the calendar
month.

 

where,

          
BALBOP = Provider of Last Resort Deferred Balance at beginning of period
excluding interest accrued subsequent to the effective date of this
Agreement

          
Mp = Number of months in the period

          
Mr = Number of months remaining in the total amortization
period

          
GWHf = Sales forecasted to be supplied by Seller for the
period

 

 

Rate shall be
calculated annually for application in the subsequent calendar
year.

 

 

 

 

 

 

 

 

 

 

 

(53237)

 

 

 

9QuickLinks
 -- Click here to rapidly navigate through this document

Exhibit 10.41  

 

 
 

SECURITIES PURCHASE AGREEMENT    
    

BY AND BETWEEN  

 THE INVESTORS LISTED ON THE SIGNATURE PAGES HERETO  

 AND  

 ALLOS THERAPEUTICS, INC.  

 MARCH 2, 2005  

 

  

 

   TABLE OF CONTENTS  

	SECTION 1.	 	INTERPRETATION OF THIS AGREEMENT	 	1
	 	1.1.	 	Defined Terms	 	1
	SECTION 2.	 	AUTHORIZATION OF SHARES; PURCHASE AND SALE OF SHARES	 	5
	 	2.1.	 	Authorization of Shares	 	5
	 	2.2.	 	Issuance of Shares	 	6
	 	2.3.	 	Closing and Closing Date	 	6
	 	2.4.	 	Delivery	 	6
	 	2.5.	 	Subsequent Sales of Shares	 	6
	SECTION 3.	 	REPRESENTATIONS AND WARRANTIES OF THE COMPANY	 	7
	 	3.1.	 	Corporate Organization	 	7
	 	3.2.	 	Subsidiaries	 	7
	 	3.3.	 	Capitalization	 	7
	 	3.4.	 	Corporate Proceedings, etc. 	 	8
	 	3.5.	 	Consents and Approvals	 	9
	 	3.6.	 	Absence of Defaults, Conflicts, etc.	 	9
	 	3.7.	 	Reports and Financial Statements	 	9
	 	3.8.	 	Absence of Certain Developments	 	10
	 	3.9.	 	Compliance with Law	 	10
	 	3.10.	 	Litigation	 	11
	 	3.11.	 	Absence of Undisclosed Liabilities	 	11
	 	3.12.	 	Employees	 	11
	 	3.13.	 	Tax Matters	 	12
	 	3.14.	 	Intellectual Property	 	12
	 	3.15.	 	Title to Tangible Assets	 	13
	 	3.16.	 	Condition of Properties	 	14
	 	3.17.	 	Transactions with Related Parties	 	14
	 	3.18.	 	Registration Statement and Prospectus	 	14
	 	3.19.	 	Registration Rights	 	14
	 	3.20.	 	Brokerage	 	15
	 	3.21.	 	Illegal or Unauthorized Payments; Political Contributions	 	15
	 	3.22.	 	Takeover Statute	 	15
	 	3.23.	 	NASDAQ Compliance	 	15
	 	3.24.	 	Reporting Status	 	15
	 	3.25.	 	No Manipulation of Common Stock	 	15
	 	3.26.	 	Accountants	 	16
	 	3.27.	 	Internal Accounting Controls	 	16
	 	3.28.	 	Environmental Matters	 	16
	 	3.29.	 	FDA Approval	 	16
	 	3.30.	 	Insurance	 	17
	 	3.31.	 	Transfer Taxes	 	17
	 	3.32.	 	Investment Company	 	17
	SECTION 4.	 	REPRESENTATIONS AND WARRANTIES OF THE INVESTORS	 	17
	SECTION 5.	 	ADDITIONAL AGREEMENTS OF THE PARTIES	 	19
	 	5.1.	 	Resale of Shares	 	19
	 	5.2.	 	Covenants Pending Closing	 	19
	 	5.3.	 	Further Assurances	 	19
	 	5.4.	 	Investor Designees	 	19
	 	5.5.	 	Subscription Right	 	20

 

	 	5.6.	 	Consents and Approvals; Proxy Statement	 	21
	 	5.7.	 	Use of Proceeds	 	22
	 	5.8.	 	Takeover Statute	 	22
	SECTION 6.	 	INVESTORS' CLOSING CONDITIONS	 	22
	 	6.1.	 	Representations and Warranties	 	22
	 	6.2.	 	Compliance with Agreement	 	23
	 	6.3.	 	Injunction	 	23
	 	6.4.	 	Counsel's Opinion	 	23
	 	6.5.	 	Adverse Development	 	23
	 	6.6.	 	Directors	 	23
	 	6.7.	 	Registration Rights Agreement	 	23
	 	6.8.	 	Standstill Agreement	 	23
	 	6.9.	 	Rights Amendment	 	23
	 	6.10.	 	Stop Orders	 	24
	 	6.11.	 	Listing of the Common Stock	 	24
	 	6.12.	 	Nasdaq Interpretive Ruling	 	24
	 	6.13.	 	Filing of Certificate of Designations	 	24
	 	6.14.	 	Officer's Certificate	 	24
	 	6.15	 	Secretary's Certificate	 	24
	 	6.16	 	Approval of Proceedings	 	25
	SECTION 7.	 	COMPANY CLOSING CONDITIONS	 	25
	 	7.1.	 	Representations and Warranties	 	25
	 	7.2.	 	Compliance with Agreement	 	25
	 	7.3.	 	Investors' Certificates	 	25
	 	7.4.	 	Injunction	 	25
	 	7.5.	 	Standstill Agreement	 	25
	 	7.6	 	Rights Agreement	 	25
	 	7.7	 	Nasdaq Interpretive Ruling	 	25
	 	7.8	 	Filing of Certificate of Designation	 	25
	 	7.9	 	Approval of Proceedings	 	25
	SECTION 8.	 	COVENANTS	 	26
	 	8.1.	 	Inspection	 	26
	 	8.2.	 	Confidentiality	 	27
	 	8.3.	 	Lost, etc. Certificates Evidencing Shares; Exchange	 	27
	 	8.4.	 	Securities Law Disclosure; Publicity	 	28
	 	8.5.	 	HSR Act Filing	 	28
	 	8.6	 	Insurance	 	28
	SECTION 9.	 	MISCELLANEOUS	 	28
	 	9.1.	 	Notices	 	28
	 	9.2.	 	Expenses and Taxes	 	29
	 	9.3.	 	Reproduction of Documents	 	30
	 	9.4.	 	Termination and Survival	 	30
	 	9.5.	 	Successors and Assigns	 	30
	 	9.6.	 	Severability	 	30
	 	9.7.	 	Governing Law	 	30
	 	9.8.	 	Paragraph and Section Headings	 	30
	 	9.9.	 	Limitation on Enforcement of Remedies	 	30
	 	9.10.	 	Counterparts	 	31
	 	9.11.	 	Entire Agreement; Amendment and Waiver	 	31

 

	

Exhibit A	
 	

Certificate of Designations
	Exhibit B	 	Restated Certificate of Incorporation, as amended
	Exhibit C	 	By-laws, as amended
	Exhibit D	 	Opinion of Cooley Godward LLP
	Exhibit E	 	Registration Rights Agreement
	Exhibit F	 	Standstill Agreement
	Exhibit G	 	Rights Amendment

ALLOS THERAPEUTICS, INC.

SECURITIES PURCHASE AGREEMENT  

Dated
as of March 2, 2005 

TO
THE INVESTORS LISTED

    ON THE SIGNATURE PAGES HERETO 

Ladies
and Gentlemen: 

        Allos
Therapeutics, Inc., a Delaware corporation (the "Company"), hereby agrees with each of the Investors (each an
"Investor" and collectively the "Investors") listed on the signature pages to this Securities
Purchase Agreement, dated as of March 2, 2005 (this "Agreement"), as follows: 

SECTION 1. INTERPRETATION OF THIS AGREEMENT  

        1.1. Defined Terms  

        As used in this Agreement, the following terms have the respective meanings set forth below or set forth in the Section hereof following such term: 

        Additional Shares:    shall have the meaning set forth in Section 2.5. 

        Affiliate:    shall mean any Person or entity, directly or indirectly, controlling, controlled by or under common control with
such Person or entity. 

        Agreement:    shall have the meaning set forth in the Introduction hereto. 

        Board:    shall have the meaning set forth in Section 3.3(c). 

        Business Day:    shall mean a day other than a Saturday, Sunday or other day on which banks in the State of New York are
required or authorized to close. 

        Certificate of Designations:    shall mean the Certificate of Designations, Number, Voting Powers, Preferences and Rights of
Series A Exchangeable Preferred Stock of the Company, a copy of which is attached hereto as Exhibit B. 

        Closing:    shall have the meaning set forth in Section 2.3. 

        Closing Date:    shall have the meaning set forth in Section 2.3. 

        Code:    shall mean the Internal Revenue Code of 1986, as amended. 

        Common Stock:    shall mean the common stock, par value $0.001 per share, of the Company. 

        Company:    shall have the meaning set forth in the Introduction hereto. 

        Company SEC Reports:    shall have the meaning set forth in Section 3.7. 

        Contract:    shall mean any material agreement, contract, commitment, understanding, arrangement, restriction or other
instrument to which the Company is currently a party, and which is or was required to be filed as an exhibit to any Company SEC Report. 

        DGCL:    shall mean the Delaware General Corporation Law. 

        Environmental Laws:    shall mean federal, state, local and foreign laws, regulations, and codes, as well as orders, decrees,
judgments or injunctions, issued, promulgated, approved or entered thereunder relating to pollution, protection of the environment or public health and safety. 

        Exchange:    shall mean the exchange of the Exchangeable Preferred Stock for shares of Common Stock in accordance with the terms
of the Certificate of Designations. 

        Exchange Act:    shall mean the Securities Exchange Act of 1934, as amended.

 

        Exchange Date Shares:    shall have the meaning set forth in Section 5.4(a). 

        Exchange Shares:    shall mean those shares of Common Stock to be issued upon exchange of the Exchangeable Preferred Stock. 

        Exchangeable Preferred Stock:    shall have the meaning set forth in Section 2.1(a). 

        FDA:    shall mean the United States Food and Drug Administration. 

        Filed Company SEC Reports:    shall have the meaning set forth in Section 3.7. 

        GAAP:    shall have the meaning set forth in Section 3.7. 

        Governmental Authority:    shall mean the government of any nation, state, city, locality or other political subdivision
thereof, any entity exercising executive, legislative, judicial, regulatory or administrative
functions of or pertaining to government, and any corporation or other entity owned or controlled, through stock or capital ownership or otherwise, by any of the foregoing. 

        HSR Act:    shall mean the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended. 

        Initial Closing:    shall have the meaning set forth in Section 2.3. 

        Initial Closing Date:    shall have the meaning set forth in Section 2.3 

        Intellectual Property:    shall mean all of the following, owned or used primarily in the current or contemplated business of
the Company: (i) registered and unregistered trademarks and service marks, trade dress, product configurations, trade names and other indications of origin, applications or registrations in any
jurisdiction pertaining to the foregoing and all goodwill associated therewith; (ii) patentable and unpatentable inventions, discoveries, improvements, ideas, know-how, formula
methodology, processes, compounds, technology, software (including password unprotected interpretive code or source code, object code, development documentation, programming tools, drawings,
specifications and data) and applications and patents in any jurisdiction pertaining to the foregoing, including re-issues, continuations, divisions,
continuations-in-part, renewals or extensions; (iii) trade secrets, including confidential information and the right in any jurisdiction to limit the use or disclosure
thereof; (iv) copyrights in writings, designs software, mask works or other works, applications or registrations in any jurisdiction for the foregoing and all moral rights related thereto;
(v) database rights; (vi) Internet Web sites, domain names and applications and registrations pertaining thereto and all intellectual property used in connection with or contained in all
versions of the Company's Web sites; (vii) rights under all agreements relating to the foregoing; (viii) books and records pertaining to the foregoing; and (ix) claims or causes
of action arising out of or related to past, present or future infringement or misappropriation of the foregoing. 

        Institutional Investors:    shall have the meaning set forth in Section 2.5. 

        Investor(s):    shall have the meaning set forth in the Introduction hereto. 

        Investor Designees:    shall have the meaning set forth in Section 5.4(a). 

        Majority Investors:    shall mean the Investors having commitments to purchase at least 70% of the Shares at the Initial
Closing. 

        Material Adverse Effect:    shall mean, collectively, a material adverse effect on, or a material adverse change in, or group of
such effects on or changes in the business, properties, business prospects, assets, liabilities, operations or condition (financial or otherwise) of the Company taken as a whole.

 

        NASD:    shall mean National Association of Securities Dealers, Inc. 

        NASDAQ Stock Market:    shall have the meaning set forth in Section 3.23. 

        Organizational Documents:    shall have the meaning set forth in Section 3.1(a). 

        Owns, Own, Owned:    shall mean the aggregate beneficial ownership, within the meaning of Rule 13d-3 under
the Exchange Act, of an Investor and any of its Affiliates. 

        Person:    shall mean an individual, partnership, joint-stock company, corporation, limited liability company, trust or
unincorporated organization, and a government or agency or political subdivision thereof. 

        Preferred Stock:    shall mean the preferred stock, par value $0.001 per share, of the Company. 

        Preferred Stock Purchase Price:    shall mean $22.10 per share. 

        Product:    shall have the meaning set forth in Section 3.29. 

        Prospectus:    shall have the meaning set forth in Section 3.18. 

        Proposed Securities:    shall have the meaning set forth in Section 5.5(a)(1). 

        Proxy Statement:    shall have the meaning set forth in Section 5.6(b). 

        Registration Rights Agreement:    shall have the meaning set forth in Section 6.7. 

        Registration Statement:    shall have the meaning set forth in Section 3.18. 

        Rights Amendment:    shall have the meaning set forth in Section 6.9. 

        Sarbanes-Oxley Act:    shall mean the Sarbanes-Oxley Act of 2002. 

        SEC:    shall mean the Securities and Exchange Commission. 

        Securities Act:    shall mean the Securities Act of 1933, as amended. 

        Shares:    shall mean the shares of Exchangeable Preferred Stock to be purchased by the Investors hereunder. 

        Standstill Agreement:    shall have the meaning set forth in Section 6.8. 

        Subsequent Closing:    shall have the meaning set forth in Section 2.3. 

        Subsidiary:    shall mean an entity of which a Person owns, directly or indirectly, more than 50% of the Voting Stock. 

        Stockholder Approval:    shall have the meaning set forth in Section 5.6(b). 

        Takeover Statute:    shall mean any corporate takeover provision under laws of the State of Delaware or any other state or
federal "fair price", "moratorium", "control share acquisition" or other similar antitakeover statute or regulation. 

        Voting Stock:    shall mean securities of any class or classes of an entity, the holders of which are ordinarily, in the absence
of contingencies, entitled to elect a majority of the corporate directors (or Persons performing similar functions). 

        WP:    shall mean Warburg Pincus Private Equity VIII, L.P., a Delaware limited partnership.

 

SECTION 2. AUTHORIZATION OF SHARES; PURCHASE AND SALE OF SHARES  

        2.1. Authorization of Shares  

        On or prior to the Initial Closing, the Company shall have authorized the sale and issuance of up to an aggregate of two million seven hundred fourteen
thousand nine hundred thirty-two (2,714,932) shares of its Series A Exchangeable Preferred Stock, par value $0.001 per share (the "Exchangeable Preferred
Stock"), on the terms and conditions set forth in this Agreement. The terms, limitations and relative rights and preferences of the Exchangeable Preferred Stock shall be as set
forth in the Certificate of Designations. 

        2.2.
Issuance of Shares

        Subject
to the terms and conditions set forth in this Agreement, and in reliance upon the Company's and the Investors' representations set forth below, at the Initial Closing, the
Company shall sell to the Investors, and the Investors shall purchase from the Company, the number of shares of Exchangeable Preferred Stock set forth opposite each Investor's respective name on  Exhibit A, at a purchase price equal to the Preferred Stock Purchase Price per share. 

        2.3.
Closing and Closing Date  

        The closing of the transactions contemplated by Section 2.2 (the "Initial Closing") shall take place at
10:00 A.M., New York City time, on the first Business Day following the date on which the last to be fulfilled or waived of the conditions set forth in Sections 6 and 7 hereof shall have
been fulfilled or
waived in accordance with this Agreement, or on such earlier date as may be mutually agreed by the Company and the Majority Investors (the "Initial Closing
Date"), at the offices of Willkie Farr & Gallagher LLP, 787 Seventh Avenue, New York, New York 10019, or such other location as the Majority Investors and the Company
shall mutually select. The subsequent closing(s) of the sale and purchase of Shares as set forth in Section 2.5 below shall take place at such time and place as the Company and the Investors
participating therein shall mutually agree (a "Subsequent Closing") (the Initial Closing and any Subsequent Closing shall collectively be referred to
herein as a "Closing" and each such date is referred to as a "Closing Date"). The Company's agreement
with each Investor is a separate agreement and the sales to each Investor are separate sales. 

        2.4.
Delivery  

        The sale and purchase of the Shares shall be effected on the applicable Closing Date by the Company executing and delivering to each Investor, duly registered in
such Investor's name, duly executed stock certificates evidencing the Shares being purchased by it, against payment of the purchase price therefore by wire transfer of immediately available funds to
such account as the Company shall designate in writing. 

        2.5.
Subsequent Sales of Shares

        At
any time on or before March 8, 2005, the Company may sell up to the balance of the authorized shares of Exchangeable Preferred Stock authorized for sale as set forth in
Section 2.1 above that are not sold to the Investors at the Initial Closing (the "Additional Shares") to not more than three (3) institutional investors (the "Institutional Investors")
each Owning more than four percent (4%) of the Common Stock outstanding on the date of this Agreement (as certified by such Institutional Investors in writing). All such sales shall be made on the
terms and conditions set forth in this Agreement, and (i) the representations and warranties of the Company set forth in Section 3 hereof (and the Disclosure Schedule) shall speak as of
the Initial Closing and the Company shall have no obligation to update any such disclosure, and (ii) the representations and warranties of the Institutional Investors in Section 4 hereof
shall speak as of such Subsequent Closing. Not more than an aggregate of four hundred fifty-two thousand four hundred eighty-nine (452,489) Additional Shares of Exchangeable
Preferred Stock may be sold to the Institutional Investors, and no Institutional Investor

 
shall acquire more than the number of shares of Exchangeable Preferred Stock that results in such Institutional Investor Owning the same percentage of the Company's outstanding Common Stock
(including, for purposes of this determination, all shares of Common Stock issuable upon exchange of the Exchangeable Preferred Stock) immediately after the Subsequent Closing (assuming, for purposes
of this determination, the issuance of all shares of Exchangeable Preferred Stock authorized for sale pursuant to Section 2.1) as such Institutional Investor Owned on the date of this Agreement
(as certified by such Institutional Investor in writing). The signature pages to this Agreement may be amended by the Company without the consent of the Investors to include any Institutional
Investors upon the execution by such Institutional Investors of a counterpart signature page hereto. Any Shares sold pursuant to this Section 2.5 shall be deemed to be "Shares" for all
purposes under this Agreement and any Institutional Investors shall be deemed to be "Investors" for all purposes under this Agreement. 

SECTION 3. REPRESENTATIONS AND WARRANTIES OF THE COMPANY  

        Except as set forth in the Disclosure Schedule delivered by the Company to the Investors at the Initial Closing or any Subsequent Closing, as the case may be, the
Company represents and warrants to the Investors as of the date of this Agreement (or, if made as of a specified date, as of such date) that: 

        3.1.
Corporate Organization

        (a)   The
Company is a corporation duly organized, validly existing and in good standing under the laws of the State of Delaware. Attached hereto as  Exhibits C and D,
 respectively, are true and complete copies of the Restated Certificate of
Incorporation and By-laws of the Company, as amended through the date hereof (collectively, the "Organizational Documents"). 

        (b)   The
Company has all requisite corporate power and authority to carry on its business as now conducted. The Company has all requisite power and authority to execute and
deliver this Agreement and to perform its obligations hereunder. 

        (c)   The
Company has filed all necessary documents to qualify to do business as a foreign corporation in each jurisdiction in which the conduct of the Company's business or
the nature of the property owned requires such qualification, except where the failure to so qualify would not be reasonably likely to have a Material Adverse Effect. 

        3.2.  Subsidiaries

        The
Company has no subsidiaries and no equity interests or investments in any partnership, trust or other entity or organization. 

        3.3.
Capitalization

        (a)   The
authorized capital stock of the Company, immediately prior to the Initial Closing, shall consist of (i) 75,000,000 shares of Common Stock and
(ii) 10,000,000 shares of Preferred Stock, of which 2,714,932 shares shall be designated as Exchangeable Preferred Stock and 1,000,000 shares shall be designated as Series A Junior
Participating Preferred Stock. As of March 2, 2005, the issued and outstanding shares of capital stock of the Company consisted of 31,175,783 shares of Common Stock and no shares of Preferred
Stock. 

        (b)   All
the outstanding shares of capital stock of the Company have been duly and validly issued and are fully paid and non-assessable, and were issued in
accordance with the registration or qualification requirements of the Securities Act and any relevant state securities laws or pursuant to valid exemptions therefrom. As of the Initial Closing Date,
the Shares will be duly authorized and, upon issuance, sale and delivery as contemplated by this Agreement, the Shares will be validly issued, fully paid and non-assessable securities of
the Company. Upon their issuance in accordance with the terms of the Exchangeable Preferred Stock, the shares of Common Stock issuable upon exchange of the

 
Exchangeable Preferred Stock will be free and clear of any and all security interests, pledges, liens, charges, claims, options, restrictions on transfer, preemptive or similar rights, proxies and
voting or other agreements, or other encumbrances of any nature whatsoever, except for those provided for herein or otherwise created or imposed upon the Investors and other than restrictions on
transfer imposed by federal or state securities laws, and except as set forth in the Standstill Agreement. 

        (c)   On
the Initial Closing Date, except for the Exchangeable Preferred Stock and except as disclosed in the Filed Company SEC Reports, there will be no shares of Common
Stock or any other equity security of the Company issuable upon conversion, exchange or exercise of any outstanding security of the Company, nor will there be any rights, options, calls or warrants
outstanding or other agreements to acquire shares of Common Stock nor will the Company be contractually obligated to purchase, redeem or otherwise acquire any of its outstanding shares. Except to the
extent otherwise provided in this Agreement or the Standstill Agreement or as disclosed in the Filed Company SEC Reports, (i) no stockholder of the Company is entitled to any preemptive or
similar rights to subscribe for shares of capital stock of the Company and no stockholder of the Company has any rights, contractual or otherwise, to designate members of the Company's Board of
Directors (the "Board"), other than in accordance with the DGCL, and (ii) there are no stockholder, voting or other agreements relating to the
rights and obligations of the Company's stockholders. 

        3.4.
Corporate Proceedings, etc.  

        The Company has authorized the execution, delivery and performance of this Agreement and each of the transactions and agreements contemplated hereby. No other
corporate action is necessary to authorize such execution, delivery and performance of this Agreement, and upon such execution and delivery, this Agreement shall constitute the valid and binding
obligation of the Company, enforceable against the Company in accordance with its terms, except that such enforcement may be subject to bankruptcy, insolvency, reorganization, moratorium or other
similar laws now or hereafter in effect relating to creditors' rights and general principles of equity. The Company has authorized the issuance and delivery of the Shares in accordance with this
Agreement and, subject to the issuance of the Shares, the Company has reserved for issuance shares of Common Stock initially issuable upon exchange of the Shares. 

        3.5.
Consents and Approvals  

        Except as otherwise provided in this Agreement, the execution and delivery by the Company of this Agreement, the issuance of any of the Shares, the performance by
the Company of its obligations hereunder and the consummation by the Company of the transactions contemplated hereby do not require the Company to obtain any consent, approval, clearance or action of,
or make any filing, submission or registration with, or give any notice to, any governmental authority or judicial authority. 

        3.6.
Absence of Defaults, Conflicts, etc.

        (a)   The
execution and delivery of this Agreement by the Company does not, and the fulfillment of the terms hereof and thereof by the Company, and the issuance, sale and
delivery of the Shares will not, (i) violate or conflict with the Organizational Documents; (ii) result in a breach of any of the terms, conditions or provisions of, or constitute a
default (with or without the giving of notice or the passage of time (or both)) under, or result in the modification of, or permit the acceleration of rights under or termination of, any Contract of
the Company; (iii) violate any law, ordinance, standard, judgment, rule or regulation of any court or federal, state or foreign regulatory board or body or administrative agency having
jurisdiction over the Company or over its properties or business; or (iv) result in the creation or imposition of any lien, encumbrance, claim, security interest or restriction whatsoever upon
any of the material properties or assets of the Company, except, in the cases of clauses (ii), (iii) or (iv), where such event would not be reasonably likely to have a Material Adverse Effect.

 

        (b)   The
Company is not in default under or in violation of (and no event has occurred and no condition exists which, upon notice or the passage of time (or both), would
constitute a default under) (i) the Company's Organizational Documents, (ii) any Contract of the Company, (iii) any license, permit or authorization to which the Company is a
party or by which it may be bound or (iv) any order, writ, injunction or decree of any court or any Federal, state, municipal or other domestic or foreign governmental department, commission,
board, bureau, agency or instrumentality except, in the case of clause (ii), (iii) or (iv), for defaults or violations which would not be reasonably likely to have a Material Adverse
Effect. Each Contract of the Company is valid, binding and enforceable against the Company and, to the Company's best knowledge, the other parties thereto, in accordance with its terms, and in full
force and effect on the date hereof. 

        3.7.
Reports and Financial Statements  

        The Company has furnished or made available to the Investors, via its EDGAR filings with the SEC, true and complete copies of the Company's (i) Annual
Reports on Form 10-K for the fiscal years ended December 31, 2003, December 31, 2002, December 31, 2001, and December 31, 2000, as amended, as
filed with the SEC, (ii) proxy statements, as amended, related to all meetings of its stockholders (whether annual or special) held since March 27, 2000, and (iii) all other
reports filed with or registration statements declared effective by the SEC since March 27, 2000, except registration statements on Form S-8 relating to employee benefit
plans, which are all the documents (other than preliminary material) that the Company was required to file with the SEC since that date (the documents referred to in clauses (i) through (iii),
together with all accompanying exhibits and all information incorporated therein by reference, being referred to herein collectively as the "Company SEC
Reports"). The Company has timely made all filings and furnishings with the SEC required of the Company pursuant to the Exchange Act during the 12 months preceding the
date of this Agreement. As of their respective dates, the Company SEC Reports were duly filed or furnished with the SEC and complied in all material respects with the requirements of the
Sarbanes-Oxley Act, the Securities Act or the Exchange Act, as the case may be, and the rules and regulations promulgated by the SEC and NASDAQ Stock Market thereunder applicable to such Company SEC
Reports. Except to the extent that information contained in any Company SEC Report filed or furnished with the SEC and made publicly available prior to the date of this Agreement (a
"Filed Company SEC Report") has been
revised or superseded by a later Filed Company SEC Report, as of their respective dates, none of the Filed Company SEC Reports contained any untrue statement of a material fact or omitted to state a
material fact required to be stated therein or necessary to make the statements therein, in light of the circumstances under which they were made, not misleading. The audited consolidated financial
statements included in the Filed Company SEC Reports comply in all material respects with applicable accounting requirements of the Securities Act or the Exchange Act and with the published rules and
regulations of the SEC with respect thereto. The financial statements (including the schedules and notes thereto) included in the Company's SEC Reports (i) have been prepared in accordance with
generally accepted accounting principles ("GAAP") applied on a consistent basis throughout the periods indicated, except as disclosed therein, and
(ii) present fairly, in all material respects, the financial position of the Company as at the dates thereof and the results of its operations and cash flow for the periods then ended, except
that the unaudited financial statements may not be in accordance with GAAP because of the absence of footnotes normally contained therein and are subject to normal year-end audit
adjustments. 

        3.8.
Absence of Certain Developments  

        Except as disclosed in the Filed Company SEC Reports, since December 31, 2003, there has been no (i) change or event which is reasonably likely to
have a Material Adverse Effect, (ii) declaration, setting aside or payment of any dividend or other distribution with respect to the capital stock of the Company, (iii) issuance of
capital stock (other than pursuant to (1) the exercise of options, warrants, or convertible securities outstanding at such date or (2) employee benefit plans) or options, warrants or

 
rights to acquire capital stock (other than the rights granted pursuant to employee benefit plans), (iv) material loss, destruction or damage to any property of the Company, whether or not
insured, (v) acceleration of any indebtedness for borrowed money or the refunding of any such indebtedness, (vi) labor trouble involving the Company or any material change in its
personnel or the terms and conditions of employment, (vii) waiver of any valuable right in favor of the Company, (viii) loan or extension of credit to any officer of the Company or to
any employee of the Company in an amount in excess of $25,000 or (ix) acquisition or disposition of any material assets (or any contract or arrangement therefore) or any other material
transaction by the Company otherwise than for fair value in the ordinary course of business. 

        3.9.
Compliance with Law

        (a)   The
Company is not in violation of any laws, ordinances, governmental rules or regulations to which it is subject, including without limitation laws or regulations
relating to the environment or to occupational health and safety, except for violations that would not be reasonably likely to have a Material Adverse Effect, and no material expenditures are known to
be or expected to be required in order to cause its current operations or properties to comply with any such laws, ordinances, governmental rules or regulations, except such expenditures as may be
required in order for the Company to comply with Section 404 of the Sarbanes-Oxley Act. 

        (b)   The
Company has all licenses, permits, franchises or other governmental authorizations necessary to the ownership of its property or to the conduct of its business in
the manner described in the Filed Company SEC Reports, which if violated or not obtained would be reasonably likely to have a Material Adverse Effect. The Company has not been finally denied any
application for any such licenses, permits, franchises or other governmental authorizations necessary to its business. 

        (c)   The
Company has not received any written notice from the FDA or any other federal, state or foreign regulatory agency questioning the manufacturing practices of any of
the Company's contractors and the Company is not aware of any intent to deliver any such written notice. 

        (d)   The
Company is in material compliance with and is taking all action required for the Company to remain in material compliance with all provisions of the Sarbanes-Oxley
Act and the rules and regulations promulgated thereunder and all provisions of the NASDAQ Stock Market, in each case as to which the Company is required to be in compliance. 

        3.10.
Litigation  

        Except as disclosed in the Filed Company SEC Reports, there is no legal action, suit, arbitration or other legal, administrative or other governmental
investigation, inquiry or proceeding (whether federal, state, local or foreign) pending or, to the best of the Company's knowledge, threatened against or affecting the Company or any of its
properties, assets or business which would be reasonably likely to have a Material Adverse Effect. The Company is not subject to any order, writ, judgment, injunction, decree, determination or award
of any court or of any governmental agency or instrumentality (whether federal, state, local or foreign). 

        3.11.
Absence of Undisclosed Liabilities  

        Except as disclosed in the Filed Company SEC Reports, subsequent to the respective dates as of which such information is given in the Filed Company SEC Reports,
the Company has not incurred any liability or obligation, direct or contingent, or entered into any transaction, not in the ordinary course of business, that is material to the Company taken as a
whole, and there has not been any change in the capital stock, or material increase in the short-term or long-term debt, of the Company taken as a whole. 

   
        3.12. Employees

        (a)   The
Company is not engaged in any unfair labor practice or discriminatory employment practice and no complaint of any such practice against the Company has been filed
or, to the best of the Company's knowledge, threatened to be filed with or by the National Labor Relations Board, the Equal Employment Opportunity Commission or any other administrative agency,
federal or state, that regulates labor or employment practices, nor is any grievance filed or, to the best of the Company's knowledge, threatened to be filed, against the Company by any employee
pursuant to any collective bargaining or other employment agreement to which the Company is a party or is bound which, in any such case, would be reasonably likely to have a Material Adverse Effect.
The Company is in compliance with all applicable foreign, federal, state and local laws and regulations regarding occupational safety and health standards except to the extent that noncompliance would
not be reasonably likely to have a Material Adverse Effect, and has received no complaints from any foreign, federal, state or local agency or regulatory body alleging such violations of any such laws
and regulations. 

        (b)   The
Company is not aware that any officer or key employee, or that any group of key employees, intends to terminate their employment with the Company, nor does the
Company have a present intention to terminate the employment of any of the foregoing. 

        3.13.
Tax Matters

        There
are no federal, state, county or local taxes due and payable by the Company which have not been paid or will not be paid prior to the time they become delinquent. The Company has
duly filed (except in cases where valid extensions have been obtained) all federal, state, county and local tax returns required to have been filed by it and there are in effect no waivers of
applicable statutes of limitations with respect to taxes for any year. No tax deficiency has been determined adversely to the Company which would be reasonably likely to have Material Adverse Effect.
The Company is not currently subject to a federal or state tax audit of any kind. 

        3.14.
Intellectual Property

        (a)   The
Company owns all right, title and interest in and to, or has a valid and enforceable license to use all the Intellectual Property used by it in connection with its
business, which represents all intellectual property rights necessary to the conduct of its business as now conducted and presently contemplated, except where the failure to own or license such
Intellectual Property would not be reasonably likely to have a Material Adverse Effect. The Company is not in breach of any license agreement concerning the Company's Intellectual Property, including
the agreements between or among the Company and the Center for Innovating Technology, the Virginia Commonwealth University or the Virginia Commonwealth University Intellectual Property Foundation,
except for breaches that would not be reasonably likely to have a Material Adverse Effect. Except as disclosed in the Filed Company SEC Reports, to the best knowledge of the Company, there are no
conflicts with or infringements of any Intellectual Property by any third party, except for conflicts or infringements that would not be reasonably likely to have a Material Adverse Effect. To the
knowledge of the Company, the conduct of the business of the Company as currently conducted or contemplated does not conflict with or infringe any proprietary right of any third party, except for
conflicts or infringements that would not be reasonably likely to have a Material Adverse Effect. There is no claim, suit, action or proceeding pending or, to the knowledge of the Company, threatened
against the Company: (i) alleging any such conflict or infringement with any third party's proprietary rights or (ii) challenging the Company's ownership or use of, or the validity or
enforceability of any Intellectual Property. 

        (b)   To
the Company's knowledge, no present or former employee, officer or director of the Company, or agent or outside contractor of the Company, holds any right, title or
interest, directly or indirectly, in whole or in part, in or to any Intellectual Property, except those formally assigned or

 
transferred to the Company by such employees, officers or directors. No person has claimed rights to any patent owned by or licensed to the Company by reason of being an inventor or
co-inventor of any claim in such patents, other than the inventors named on each such patent, and all such inventors have duly assigned their rights to the patents to the Company or the
assignor or licensor of such patents to the Company. 

        (c)   Neither
the execution nor delivery of this Agreement, nor the carrying on of the Company's business by the employees of and consultants to the Company will, to the
Company's knowledge, conflict with or result in a breach of the terms, conditions or provisions of, or constitute a default under, any Contract (including covenants or commitments of any nature) which
any of such employees or consultants is now obligated. The Company does not believe it is or will be necessary to utilize any inventions of any of its employees (or people it currently intends to
hire) made prior to their employment by the Company, except those formally assigned or transferred to the Company by such employees. 

        (d)   To
the Company's knowledge: (i) no trade secret of the Company has been used, disclosed or appropriated to the detriment of the Company or for the benefit of any
Person other than the Company; and (ii) no employee, independent contractor or agent of the Company has misappropriated any trade secrets or other confidential information of any other Person
in the course of the performance of his or her duties as an employee, independent contractor or agent of the Company, except in the cases of clauses (i) and (ii) as would not be
reasonably likely to have a Material Adverse Effect. All employees of the Company have executed agreements acknowledging their obligation to assign all inventions made in the course of their
employment to the Company. 

        (e)   Each
employee, consultant and contractor of the Company who has had access to confidential information of the Company which is necessary for the conduct of the Company's
business as currently conducted or as currently proposed to be conducted has executed an agreement to maintain the confidentiality of such confidential information and has executed appropriate
agreements that are substantially consistent with the Company's standard forms thereof. 

        3.15.  Title to Tangible Assets

        The
Company has good and marketable title to its properties and assets and good title to all its leasehold estates, in each case except as disclosed in the Filed Company SEC Reports
subject to no mortgage, pledge, lien, lease, encumbrance or charge, other than or resulting from taxes which have not yet become delinquent and minor liens and encumbrances which do not in any case
materially detract from the value of the property subject thereto or materially impair the operations of the Company and which have not arisen otherwise than in the ordinary course of business. 

        3.16.  Condition of Properties

        The
property, assets and operations of the Company comply with all applicable ordinances, regulations and laws, except where the failure to so comply would not be reasonably likely to
have a Material Adverse Effect. 

        3.17.
Transactions with Related Parties

        Except
as disclosed in the Filed Company SEC Reports, the Company is not a party to any agreement with any of the Company's directors, officers or stockholders or any Affiliate or family
member of any of the foregoing under which it: (i) leases any real or personal property (either to or from such Person); (ii) licenses technology (either to or from such Person);
(iii) is obligated to purchase any tangible or intangible asset from or sell such asset to such Person; (iv) purchases products or services from such Person; or (v) has borrowed
money from or lent money to such Person. The Company does not employ as an employee or engage as a consultant any family member of any of the Company's directors, officers or stockholders. Except as
set forth in the Standstill Agreement, to the

 
best knowledge of the Company, there exist no agreements among stockholders of the Company to act in concert with respect to the voting or holding of the Company's securities. 

        3.18.  Registration Statement and Prospectus

        A
registration statement on Form S-3 (File No. 333-113353) (the "Registration Statement") with
respect to the Shares has been prepared by the Company in conformity with the requirements of the Securities Act and the rules and regulations of the SEC thereunder and has been filed with the
Commission under the Securities Act. The Registration Statement, which shall be deemed to include all information omitted therefrom in reliance upon Rule 430A and contained in the Prospectus
referred to below, has been declared effective by the SEC under the Securities Act and no post-effective amendment to the Registration Statement has been filed as of the date of this
Agreement. The form of the prospectus filed by the Company with the SEC pursuant to its Rule 424(b) and Rule 430A and dated April 21, 2004, is herein referred to as the
"Prospectus." 

        The
SEC has not issued an order preventing or suspending the use of the Prospectus relating to the offering of the Shares nor instituted proceedings for that purpose. The Registration
Statement and the Prospectus contain all statements which are required to be stated therein by, and in all respects conform, as the case may be, to the requirements of the Securities Act and the rules
and regulations of the SEC thereunder. Neither the Registration Statement nor any amendment thereto, nor the Prospectus, contains, as the case may be, any untrue statement of a material fact or omits
to state any material fact required to be stated therein or necessary to make the statements made therein, in light of the circumstances under which they were made, not misleading. 

        3.19.
Registration Rights

        Except
as disclosed in the Filed Company SEC Reports and pursuant to the Registration Rights Agreement, the Company will not, as of the Initial Closing Date, be under any obligation to
register any of its securities under the Securities Act. 

        3.20.
Brokerage

        Except
for fees payable pursuant to that certain letter agreement dated February 24, 2005, by and between the Company and Needham & Company, a copy of which has been
provided to WP, there are no claims for brokerage commissions or finder's fees or similar compensation in connection with the transactions contemplated by this Agreement based on any arrangement made
by or on behalf of the Company and the Company agrees to indemnify and hold the Investors harmless against any costs or damages incurred as a result of any such claim. 

        3.21.
Illegal or Unauthorized Payments; Political Contributions

        Neither
the Company nor, to the best of the Company's knowledge (after reasonable inquiry of its officers and directors), any of the officers, directors, employees, agents or other
representatives of the Company or any other business entity or enterprise with which the Company is or has been affiliated or associated, has, directly or indirectly taken any action prohibited by
Section 30A of the Exchange Act. 

        3.22.
Takeover Statute

        The
Board has taken all action necessary to approve the transactions contemplated hereby, as it relates to the Investors, for the purposes of the provisions of Section 203 of the
DGCL. To the Company's knowledge, no other Takeover Statute is applicable to the transactions contemplated hereby. 

        3.23.
NASDAQ Compliance

        The
Common Stock is registered pursuant to Section 12(g) of the Exchange Act, and is listed on The NASDAQ National Market (the "NASDAQ Stock
Market"), and trading in the Common Stock has not been suspended and the Company has taken no action designed to, or that is likely to have the

 
effect of, terminating the registration of the Common Stock under the Exchange Act or delisting the Common Stock from the NASDAQ Stock Market, nor has the Company received any notification that the
SEC or the NASD is contemplating terminating such registration or listing. To the best of the Company's knowledge, the Company and the Common Stock meet the criteria for continued listing and trading
on the NASDAQ Stock Market. 

        3.24.
Reporting Status

        The
Company is currently eligible to register the resale of Common Stock in a secondary offering on a registration statement on Form S-3 under the Securities Act. 

        3.25.
No Manipulation of Common Stock

        The
Company has not taken and will not take any action outside the ordinary course of business designed to or that might reasonably be expected to cause or result in unlawful
manipulation of the price of the Common Stock to facilitate the sale or resale of the Shares or the Exchange Shares. 

        3.26.  Accountants

        PricewaterhouseCoopers
LLP has advised the Company that it is, and to the best knowledge of the Company it is, an independent accountant as required by the Sarbanes-Oxley Act, the
Securities Act and the Exchange Act and the rules and regulations promulgated thereunder. 

        3.27.
Internal Accounting Controls

        The
Company maintains a system of internal accounting controls sufficient, in the judgment of the management of the Company, to provide reasonable assurance that: (i) transactions
are executed in accordance with management's general or specific authorizations; (ii) transactions are recorded as necessary to permit preparation of financial statements in conformity with
generally accepted accounting principles and to maintain asset accountability; (iii) access to assets is permitted only in accordance with management's general or specific authorization; and
(iv) the recorded accountability for assets is compared with the existing assets at reasonable intervals and appropriate action is taken with respect to any differences. 

        3.28.  Environmental Matters

        To
its knowledge, the Company is in compliance with all applicable Environmental Laws, except where any failure to comply would not be reasonably likely to have a Material Adverse
Effect. There is no civil, criminal or administrative judgment, action, suit, demand, claim, hearing, notice of violation, investigation, proceeding, notice or demand letter pending or to the
Company's knowledge threatened against the Company pursuant to Environmental Laws. To the Company's knowledge, there are no past
or present events, conditions, circumstances, activities, practices, incidents, agreements, actions or plans which could reasonably be expected to prevent compliance with, or which have given rise to
or will give rise to liability which would have a Material Adverse Effect, under Environmental Laws. 

        3.29.
FDA Approval

        After
due investigation, (i) the Company has no knowledge that any Governmental Authority, including, but not limited to, the FDA, will ultimately prohibit the marketing, sale,
license or use in the United States or elsewhere of any product (including, but not limited to, EFAPROXYN) proposed to be developed, produced or marketed by the Company (each, a
"Product"), (ii) to the Company's knowledge, the FDA has not prohibited any product or process from being marketed or used in the United States
which product or process is substantially similar in function or composition to the Company's lead product candidate, EFAPROXYN, (iii) the Company has no Product on clinical hold nor does the
Company have any reason to expect that any Product is reasonably likely to be placed on clinical hold, (iv) the Company has made available to WP all submissions to the FDA and the FDA responses
(and other material correspondence received from or submitted to the FDA), including, but

 
not limited to, all FDA warning letters, regulatory letters and notice of adverse finding letters and the relevant responses, received by the Company or any agent thereof relative to the development
of its Products, including, but not limited to, EFAPROXYN, (v) none of the Company or its Affiliates or, to the Company's knowledge, its employees or agents, has ever been sanctioned, formally
or otherwise, by the FDA, and (vi) there has not been any suspensions or debarments by the FDA or other federal departments and state regulatory bodies against the Company or, to the knowledge
of the Company, any current or former employee of the Company. 

        3.30.
Insurance

        The
Company maintains and will continue to maintain insurance with financially sound and reputable insurers in such amounts and covering such risks as is reasonably adequate and
consistent with industry practice for the conduct of its business and the value of its property, all of which insurance is in full force and effect. The Company has not received notice from, and has
no knowledge of any threat by, any insurer that has issued any insurance policy to the Company that such insurer intends to deny coverage under or cancel, discontinue or not renew any insurance policy
presently in force. 

        3.31.
Transfer Taxes

        On
the Initial Closing Date, all stock transfer or other taxes (other than income taxes) which are required to be paid in connection with the sale and issuance of the Shares hereunder
will be, or will have been, fully paid or provided for by the Company and the Company will have complied with all laws imposing such taxes. 

        3.32.
Investment Company

        The
Company is not an "investment company" or an "affiliated person" of, or "promoter" or "principal underwriter" for an investment company, within the meaning of the Investment Company
Act of 1940, as amended. 

SECTION 4. REPRESENTATIONS AND WARRANTIES OF THE INVESTORS  

        Each Investor severally represents and warrants to the Company as of the date of this Agreement (or, if made as of a specified date, as of such date) that: 

        (a)   It
is acquiring the Shares and, subject to Stockholder Approval, the Exchange Shares for its own account for investment and not with a view towards the resale, transfer
or distribution thereof, nor with any present intention of distributing the Shares or the Exchange Shares, but subject, nevertheless, to any requirement of law that the disposition of the Investor's
property shall at all times be within the Investor's control, and without prejudice to the Investor's right at all times to sell or otherwise dispose of all or any part of such securities under a
registration under the Securities Act or under an exemption from said registration available under the Securities Act. 

        (b)   It
has full power and legal right to execute and deliver this Agreement and to perform its obligations hereunder. 

        (c)   It
is a validly existing partnership, limited liability company, trust or corporation, as the case may be, duly organized under the laws of its jurisdiction of
organization or formation. 

        (d)   It
has taken all action necessary for the authorization, execution, delivery, and performance of this Agreement and its obligations hereunder, and, upon execution and
delivery by the Company, this Agreement shall constitute the valid and binding obligation of such Investor, enforceable against such Investor in accordance with its terms, except that such enforcement
may be limited by bankruptcy, insolvency, reorganization, moratorium or other similar laws now or hereafter in effect relating to creditors' rights and general principles of equity.

 

        (e)   There
are no claims for brokerage commissions or finder's fees or similar compensation in connection with the transactions contemplated by this Agreement based on any
arrangement made by or on behalf of such Investor and such Investor agrees to indemnify and hold the Company harmless against any costs or damages incurred as a result of any such claim. 

        (f)    It
has such knowledge and experience in financial and business matters that it is capable of evaluating the merits and risks of its investment in the Company as
contemplated by this Agreement, and is able to bear the economic risk of such investment for an indefinite period of time. It has been furnished access to such information and documents as it has
requested and has been afforded an opportunity to ask questions of and receive answers from representatives of the Company concerning the terms and conditions of this Agreement and the purchase of the
Shares contemplated hereby. It is a "qualified institutional buyer" within the meaning of Rule 144A(a) of the Securities Act or an "accredited investor" within the meaning of
Rule 501(a) of Regulation D under the Securities Act. 

        (g)   Except
such consents, approvals and filings, the failure to obtain or make would not, individually or in the aggregate, have a material adverse effect on the ability of
the Investor to consummate the transactions contemplated by this Agreement, the execution and delivery by it of this Agreement and the performance by such Investor of its obligations hereunder and the
consummation by such Investor of the transactions contemplated hereby do not require such Investor to obtain any consent, approval, clearance or action of, or make any filing, submission or
registration with, or give any notice to, any governmental authority or judicial authority. 

        (h)   The
execution and delivery of this Agreement by such Investor do not, and the fulfillment of the terms hereof and thereof by such Investor will not, (i) violate
or conflict with its partnership agreement, trust agreement, the articles of incorporation, other constitutive documents or by-laws (or other similar applicable documents) of the Investor,
as applicable; (ii) result in a breach of any of the terms, conditions or provisions of, or constitute a default (with or without the giving of notice or the passage of time (or both)) under,
or result in the modification of, or permit the acceleration of rights under or termination of, any material contract to which such Investor is a party or (iii) violate any law, ordinance,
standard, judgment, rule or regulation of any court or federal, state or foreign regulatory board or body or administrative agency having jurisdiction over such Investor or over its respective
properties or businesses; except, in the cases of clauses (ii) and (iii) where such event would not be reasonably likely to have a material adverse effect on the Investor's ability to
consummate the transactions contemplated by this Agreement. 

        (i)    On
the date of this Agreement, the Investor (1) is not an "interested stockholder" within the meaning of Section 203(c)(5) of the DGCL or
(2) has been an "interested stockholder" for a period of more than three years preceding the date of this Agreement. 

SECTION 5. ADDITIONAL AGREEMENTS OF THE PARTIES  

        5.1. Resale of Shares  

        Each Investor severally covenants that it will not sell or otherwise transfer the Shares or, subject to Stockholder Approval, the Exchange Shares, except pursuant
to an effective registration under the Securities Act or in a transaction which, in the opinion of counsel reasonably satisfactory to the Company, qualifies as an exempt transaction under the
Securities Act and the rules and regulations promulgated thereunder. 

        5.2.
Covenants Pending Closing  

        Pending the Initial Closing, the Company will conduct its business in the ordinary course, and will not, without the Investors' prior written consent, such
consent not to be unreasonably withheld, delayed or conditioned, take any action which would result in any of the representations or warranties contained in this Agreement not being true at and as of
the time immediately after such action, or in

 
any of the covenants contained in this Agreement becoming incapable of performance. Pending the Initial Closing, the Company will promptly advise the Investors of any action or event of which it
becomes aware which has the effect of making materially incorrect any of such representations or warranties or which has the effect of rendering any of such covenants incapable of performance. 

        5.3.
Further Assurances  

        The Company and each Investor shall execute such documents and other papers and take such further actions as may be reasonably required or desirable to carry out
the provisions hereof and the transactions contemplated hereby. The Company and each Investor shall use its reasonable efforts to fulfill or obtain the fulfillment of the conditions to the Closing as
promptly as practicable. 

        5.4.  Investor Designees

        (a)   For
so long as WP Owns at least two thirds of (i) the aggregate number of Shares acquired by it on the Initial Closing Date, or (ii) in the event the
Exchange occurs, the aggregate number of shares of Common Stock Owned by WP immediately after giving effect to the Exchange (the "Exchange Date
Shares"), then, subject to applicable law and the rules and regulations of the SEC and NASDAQ Stock Market, the Company will nominate and use its reasonable best efforts to
cause to be elected and cause to remain as directors on the Board two individuals designated by WP (each, an "Investor Designee" and collectively, the
"Investor Designees"). 

        (b)   In
the event Section 5.4(a) is no longer applicable and for so long as WP Owns at least 50% of (i) the aggregate number of Shares acquired by it on
the Initial Closing Date, or (ii) in the event the Exchange occurs, the Exchange Date Shares, then, subject to applicable law and the rules and regulations of the SEC and NASDAQ Stock Market,
the Company will nominate and use its reasonable best efforts to cause to be elected and cause to remain as a director on the Board, one Investor Designee. 

        (c)   Subject
to applicable law and the rules and regulations of the SEC and NASDAQ Stock Market, for so long as at least one Investor Designee continues to serve as a
director on the Board, the Company will use its reasonable best efforts to cause one of the Investor Designees to be a member of each principle committee of the Board. 

        5.5.
Subscription Right

        (a)   If
at any time after the date hereof, the Company determines to issue equity securities of any kind (for these purposes, the term "equity
securities" shall include, without limitation, Common Stock, warrants, options or other rights to acquire equity securities convertible or exchangeable into equity securities)
of the Company (other than: (i) to the public in a firm commitment underwriting pursuant to a registration statement filed under the Securities Act; (ii) the issuance of equity
securities to employees, officers or directors of, or consultants or advisors to the Company pursuant to any employee benefit plan approved by the Board; (iii) any equity securities issued as
consideration in connection with an acquisition, merger or consolidation by the Company provided such acquisition, merger or consolidation has been approved by the Board; (iv) securities issued
in connection with licensing, marketing or distribution arrangements or similar strategic transactions approved by the Board; (v) stock issued or issuable pursuant to any rights or agreements
outstanding as of the date of this Agreement, including warrants outstanding as of the date of this Agreement to purchase up to 1,706,893 shares of Common Stock, and stock issued pursuant to any such
rights or agreements granted after the date of this Agreement approved by the Board; provided that the subscription rights established by this
Section 5.5 apply with respect to the initial sale or grant by the Company of such rights or agreements; (vi) shares of Exchangeable Preferred Stock issued as dividends with respect to
the Shares purchased by the Investors hereunder, or (vii) shares of Common Stock issued or issuable upon exchange of the Exchangeable Preferred Stock) then, for so long as WP Owns at least
two-thirds

 
of (i) the aggregate number of Shares acquired by it on the Initial Closing Date, or (ii) in the event the Exchange occurs, the Exchange Date Shares, the Company shall: 

        (1)   give
written notice to WP setting forth in reasonable detail (A) the designation and all of the terms and provisions of the securities proposed to be issued (the
"Proposed Securities"), including, where applicable, the voting powers, preferences and relative participating, optional or other special rights, and
the qualification, limitations or restrictions thereof and interest rate and maturity; (B) the price and other terms of the proposed sale of such securities; (C) the amount of such
Proposed Securities; and (D) such other information as WP may reasonably request in order to evaluate the proposed issuance; and 

        (2)   subject
to applicable law and the rules and regulations of the SEC and NASDAQ Stock Market, offer to issue to WP upon the terms described in the notice delivered
pursuant to Section 5.5(a)(1) above, a portion of the Proposed Securities equal to (i) the percentage of the Common Stock (including the Exchange Shares issuable upon the
Exchange, if the Exchange has not occurred) Owned by WP immediately prior to the issuance of the equity securities relative to the total number of shares of Common Stock (including the Exchange Shares
issuable upon the Exchange, if the Exchange has not occurred) outstanding immediately prior to the issuance of the equity securities, multiplied by (ii) the total number of Proposed Securities.
Notwithstanding the foregoing, the Company shall not be required to offer or sell such Proposed Securities to WP if it would cause the Company to be in violation of applicable federal securities laws
by virtue of such offer or sale. 

        (b)   WP
must exercise its purchase rights hereunder within 5 Business Days after receipt of such notice from the Company. To the extent that the Company offers two or more
securities in units, WP must purchase such units as a whole and will not be given the opportunity to purchase only one of the securities making up such unit. 

        (c)   Upon
the expiration of the offering period described above, the Company will be free to sell such Proposed Securities that WP has not elected to purchase during the
90 days following such expiration on terms and conditions no more favorable to the purchasers thereof than those offered to WP. 

        (d)   The
election by WP not to exercise its subscription rights under this Section 5.5 in any one instance shall not affect its right (other than in respect of a
reduction in its percentage holdings) as to any subsequent proposed issuance. Any sale of such securities by the Company without first giving WP the rights described in this Section 5.5 shall
be void and of no force and effect. 

        (e)   The
subscription rights established by this Section 5.5 shall not apply to, and shall terminate upon a consolidation, merger, reorganization or other form of
acquisition of or by the Company in which the Company's stockholders immediately prior to the transaction retain less than 50% of the voting power of or economic interest in the surviving or resulting
entity (or its parent), or a sale of the Company's assets in excess of a majority of the Company's assets (valued at fair market value as determined in good faith by the Board). 

        (f)    Injunctive Relief. The Company and WP hereby declare that it is impossible to measure in money the damages which will
accrue to the parties hereto by reason of the failure of any party to perform any of its obligations set forth in this Section 5.5. Therefore, the Company and WP shall have the right to
specific performance of such obligations, and if any party hereto shall institute any action or proceeding to enforce the provisions hereof, each of the Company and WP hereby waive the claim or
defense that the party instituting such action or proceeding has an adequate remedy at law. 

   
        5.6. Consents and Approvals; Proxy Statement

        (a)   From
and after the date hereof, the Company shall use its reasonable best efforts to obtain as promptly as practicable any consent or approval of any Person, including
any regulatory authority, required in connection with the transactions contemplated hereby. 

        (b)   From
and after the date of the Initial Closing, the Company shall use its reasonable best efforts to obtain as promptly as practicable any vote of stockholders necessary
for approval of the Exchange ("Stockholder Approval"). In furtherance of the foregoing statement, as promptly as reasonably practicable after the date
hereof and in any event no later than March 25, 2005, the Company shall prepare and file with the SEC, and shall use its reasonable best efforts to have cleared by the SEC, a preliminary proxy
statement, and as soon as practicable thereafter (subject to applicable waiting periods under the Exchange Act, review by the SEC or as required by the Organizational Documents and applicable law)
file with the SEC and promptly thereafter mail a definitive proxy statement to the Company's stockholders (the "Proxy Statement"). The Proxy Statement
shall contain the recommendation of the Board, to the extent consistent with its fiduciary duties, that the Company's stockholders approve the Exchange in accordance with the Organizational Documents
and applicable law, including without limitation, the requirements of NASD Rule 4350. WP will be given a reasonable opportunity to review and comment on drafts of the Proxy Statement and the
Company will use its reasonable best efforts to accept comments thereto given by WP and its representatives. The Company shall promptly take all action necessary in accordance with applicable law and
its Organizational Documents to convene a meeting of the Company's stockholders, no later than May 30, 2005 or, if such date is impracticable due to review by the SEC, as soon as practicable
thereafter. To the extent consistent with its fiduciary duties, the Company shall use its reasonable best efforts to solicit from the Company's stockholders proxies in favor of the Exchange and shall
take all other action reasonably necessary to secure Stockholder Approval. 

        5.7.
Use of Proceeds  

        The proceeds received by the Company from the issuance and sale of the Shares shall be used by the Company for working capital and other general corporate
purposes. 

        5.8.
Takeover Statute  

        If any Takeover Statute shall become applicable to the transactions contemplated hereby, including without limitation any takeover provision under the laws of the
State of Delaware, the Company and the members of the Board shall, to the extent consistent with its fiduciary duties, grant such approvals and take such actions as are necessary so that the
transactions contemplated hereby may be consummated as promptly as practicable on the terms contemplated hereby and otherwise use their reasonable best efforts to act to eliminate or minimize the
effects of such statute or regulation on the transactions contemplated hereby. 

SECTION 6. INVESTORs' CLOSING CONDITIONS  

        The Investors' obligations to purchase the Shares at each Closing shall be subject to the performance by the Company of its agreements theretofore to be performed
hereunder and to the satisfaction (or waiver), prior thereto or concurrently therewith, of the following further conditions: 

        6.1.
Representations and Warranties  

        The representations and warranties of the Company contained in Section 3 of this Agreement shall be true on and as of the Initial Closing Date in all
material respects (except for such representations and warranties that are qualified as to materiality, which shall be true in all respects) as though such representations and warranties were made at
and as of such date.

 

        6.2.
Compliance with Agreement  

        The Company shall have performed and complied in all material respects with all agreements, covenants and conditions contained in this Agreement which are
required to be performed or complied with by the Company prior to or on the applicable Closing Date. 

        6.3.  Injunction  

        There shall be no effective injunction, writ, preliminary restraining order or any order of any nature issued by a court of competent jurisdiction directing that
the transactions provided for herein or any of them not be consummated as herein provided. 

        6.4.
Counsel's Opinion  

        Each Investor shall have received an opinion, dated the applicable Closing Date from the Company's counsel, Cooley Godward LLP, substantially in the form of  Exhibit E attached hereto. 

        6.5.
Adverse Development  

        There shall have been no developments in the business of the Company which would be reasonably likely to have a Material Adverse Effect. 

        6.6.
Directors  

        Stewart Hen and Jonathan S. Leff shall have been elected to the Board, effective on the Initial Closing Date. Subject to the applicable law and the rules and
regulations of the SEC and NASDAQ Stock Market, one of the Investor Designees shall be a member of each principle committee of the Board. 

        6.7.
Registration Rights Agreement  

        The Company and the Investors shall have executed the Registration Rights Agreement, the form of which is attached as  Exhibit F
hereto (the "Registration Rights Agreement"). 

        6.8.  Standstill Agreement  

        The Company and WP shall have executed the letter agreement, the form of which is attached as Exhibit G
hereto (the "Standstill Agreement"). 

        6.9.
Rights Amendment  

        The Company and Mellon Investor Services LLC, as Rights Agent, shall have executed the Amendment to Rights Agreement, the form of which is attached as  Exhibit H hereto (the "Rights Amendment").
 

        6.10.
Stop Orders  

        No stop order or suspension of trading shall been imposed by the NASDAQ Stock Market, the SEC or any other governmental regulatory body with respect to public
trading in the Common Stock. 

        6.11.
Listing of the Common Stock  

        In connection with the issuance of the Shares and the transactions contemplated hereby, the Company shall have submitted to the NASDAQ Stock Market a
"Notification Form: Listing of Additional Shares" as well as any necessary supporting documentation. 

        6.12.  Nasdaq Interpretative Ruling  

        The NASDAQ Stock Market shall have issued a written interpretation confirming that the transactions contemplated hereby, including the terms of the Exchangeable
Preferred Stock, comply with all applicable Nasdaq rules, including the requirements of Rule 4350(i) and IM-4350-2

 
("Interpretive Material Regarding the Use of Share Caps to Comply with Rule 4350(i)") and the voting rights requirements of Rule 4351 and
IM-4351 ("Voting Rights Policy"). 

        6.13.
Filing of Certificate of Designations  

        The Certificate of Designations shall have been filed with the Secretary of State of the State of Delaware and shall continue to be in full force and effect as of
the applicable Closing Date. 

        6.14.
Officer's Certificate  

        Each Investor shall have received a certificate, dated the applicable Closing Date, signed by a duly authorized executive officer of the Company, certifying that
the conditions specified in the foregoing Sections 6.1, 6.2, 6.3 and 6.5 hereof have been fulfilled. 

        6.15.
Secretary's Certificate  

        Each Investor shall have received a certificate, dated the applicable Closing Date, of the Secretary of the Company attaching: (i) a true and complete copy
of the Restated Certificate of Incorporation of the Company, with all amendments thereto; (ii) true and complete copies of the Company's By-laws, as amended, in effect as of such
date; (iii) a certificate from the Secretary of State of the State of Delaware as to the good standing of the Company; (iv) certificates of good standing from the appropriate officials
of the jurisdictions in each state in which the Company is qualified to do business as a foreign corporation; and (iv) resolutions of the Board authorizing the execution and delivery of this
Agreement, the transactions contemplated hereby, and the issuance of the Shares. 

        6.16.
Approval of Proceedings  

        All proceedings to be taken in connection with the transactions contemplated by this Agreement, and all documents incident thereto, shall be satisfactory in form
and substance to WP and its special counsel, Willkie Farr & Gallagher LLP. WP shall have received copies of all documents or other evidence which they and Willkie Farr & Gallagher LLP
may reasonably request in connection with such transactions and of all records of corporate proceedings in connection therewith in form and substance reasonably satisfactory to WP and Willkie
Farr & Gallagher LLP. 

SECTION 7. COMPANY CLOSING CONDITIONS  

        The Company's obligation to issue and sell the Shares at each Closing shall be subject to the performance by each Investor of its agreements theretofore to be
performed hereunder and to the satisfaction (or waiver), prior thereto or concurrently therewith, of the following further conditions: 

        7.1.
Representations and Warranties  

        The representations and warranties of the Investors contained in Section 4 of this Agreement shall be true in all material respects on and as of the
applicable Closing Date (except for such representations
and warranties that are qualified as to materiality, which shall be true in all respects) as though such representations and warranties were made at and as of such date. 

        7.2.
Compliance with Agreement  

        The Investors shall have performed and complied in all material respects with all agreements, covenants and conditions contained in this Agreement which are
required to be performed or complied with by them prior to or on the applicable Closing Date. 

        7.3.
Investors' Certificates  

        The Company shall have received a certificate from each Investor, dated the applicable Closing Date, signed by a duly authorized representative of the Investor,
certifying that the conditions specified in the foregoing Sections 7.1 and 7.2 hereof have been fulfilled.

 

        7.4.
Injunction  

        There shall be no effective injunction, writ, preliminary restraining order or any order of any nature issued by a court of competent jurisdiction directing that
the transactions provided for herein or any of them not be consummated as herein provided. 

        7.5.
Standstill Agreement  

        The Company and WP shall have executed the letter agreement, the form of which is attached as Exhibit G
hereto (the "Standstill Agreement"). 

        7.6.
Rights Amendment  

        The Company and Mellon Investor Services LLC, as Rights Agent, shall have executed the Amendment to Rights Agreement, the form of which is attached as  Exhibit H hereto (the "Rights Amendment"). 

        7.7.  Nasdaq Interpretative Ruling  

        The NASDAQ Stock Market shall have issued a written interpretation confirming that the transactions contemplated hereby, including the terms of the Exchangeable
Preferred Stock, comply with all applicable Nasdaq rules, including the requirements of Rule 4350(i) and IM-4350-2 ("Interpretive Material
Regarding the Use of Share Caps to Comply with Rule 4350(i)") and the voting rights requirements of Rule 4351 and IM-4351
("Voting Rights Policy"). 

        7.8.
Filing of Certificate of Designations  

        The Certificate of Designations shall have been filed with the Secretary of State of the State of Delaware and shall continue to be in full force and effect as of
the applicable Closing Date. 

        7.9.
Approval of Proceedings  

        All proceedings to be taken in connection with the transactions contemplated by this Agreement, and all documents incident thereto, shall be reasonably
satisfactory in form and substance to the Company. The Company shall have received copies of all documents or other evidence which it may have reasonably requested in connection therewith in form and
substance reasonably satisfactory to the Company. 

SECTION 8. COVENANTS  

        8.1. Inspection  

        As long as an Investor Owns at least twenty percent (20%) of the outstanding Common Stock, the Company shall permit the Investor, its nominee, assignee, and its
representative to visit and inspect any of the properties of the Company, to examine all its books of account, records, reports and other papers, to make copies and extracts therefrom, and provide
reasonable access to and the right to consult with, its officers, directors, key employees and independent public accountants or any of them
(and by this provision the Company authorizes said accountants to discuss with such Investor, its nominees, assignees and representatives the finances and affairs of the Company), all at such
reasonable times and as often as may be reasonably requested; provided, however, that the Company shall
not be obligated under this Section 8.1 with respect to information the Company is contractually obligated to keep confidential or secret or which the Board of Directors determines in good
faith is confidential and should not, therefore, be disclosed. 

        8.2.
Confidentiality

        (a)   As
to so much of the information and other material furnished under or in connection with this Agreement (including without limitation information furnished pursuant to
Section 8.1 hereof) as

 
constitutes or contains confidential business, financial or other information of the Company, each Investor covenants for itself and its members and officers that it will use due care to prevent its
officers, members, employees, counsel, accountants, consultants, advisors and other representatives from disclosing such information to Persons other than their respective authorized employees,
counsel, accountants, stockholders, partners, limited partners and other authorized representatives or from using such information except as an Investor or for the benefit of the Company;  provided,
however, that such Investor may disclose or deliver any information or other material
disclosed to or received by it should the Investor be advised by its counsel that such disclosure or delivery is required by law, regulation or judicial or administrative order. In the event of any
termination of this Agreement prior to the Initial Closing Date, the Investor shall return to the Company all confidential material previously furnished to the Investor or its officers, members,
employees, counsel, accountants and other representatives in connection with this transaction. For purposes of this Section 8.2, "due care" means
at least the same level of care that such Investor would use to protect the confidentiality of its own sensitive or proprietary information, and this obligation shall survive termination of this
Agreement. 

        (b)   Notwithstanding
the foregoing or anything else contained herein to the contrary, the terms and conditions of (i) that certain Non-Disclosure Agreement
dated January 11, 2005, between the Company and WP, and (ii) that certain Non-Disclosure Agreement dated January 27, 2005, between the Company and WP, shall remain in
full force and effect in accordance with their terms with respect to all confidential information of the Company disclosed to WP thereunder. 

        8.3.
Lost, etc. Certificates Evidencing Shares; Exchange  

        Upon receipt by the Company of evidence reasonably satisfactory to it of the loss, theft, destruction or mutilation of any certificate evidencing any Shares or
Exchange Shares owned by an Investor, and (in the case of loss, theft or destruction) of an unsecured indemnity satisfactory to it, and upon reimbursement to the Company of all reasonable expenses
incidental thereto, and upon surrender and
cancellation of such certificate, if mutilated, the Company will make and deliver in lieu of such certificate a new certificate of like tenor and for the number of securities evidenced by such
certificate which remain outstanding. Each Investor's agreement of indemnity shall constitute indemnity satisfactory to the Company for purposes of this Section 8.3. Upon surrender of any
certificate representing any Shares or Exchange Shares, for exchange at the office of the Company, the Company at its expense will cause to be issued in exchange therefor new certificates in such
denomination or denominations as may be requested for the same aggregate number of Shares or Exchange Shares represented by the certificate so surrendered and registered as such holder may request.
The Company will also pay the cost of all deliveries of certificates for such Shares or Exchange Shares to the office of the Investor (including the cost of insurance against loss or theft in an
amount satisfactory to the holders) upon any exchange provided for in this Section 8.3. 

        8.4.
Securities Law Disclosure; Publicity

        The
Company shall, at or prior to 8:30 a.m., Eastern Standard Time, on the first day following the date of this Agreement on which trading occurs on the NASDAQ Stock Market,
(i) issue a press release reasonably acceptable to the Majority Investors disclosing the transactions contemplated hereby, and (ii) file a Current Report on
Form 8-K with the SEC (the "8-K Filing") describing the transactions contemplated hereby and including this Agreement as
an exhibit thereto, in the form required by the Exchange Act. Thereafter, the Company shall timely file any filings and notices required by the SEC or the NASD with respect to the transactions
contemplated hereby. Notwithstanding the foregoing, the Company shall not publicly disclose the name of any Investor, or include the name of any Investor in any filing with the SEC (other than
pursuant to the Registration Statement and exhibits to the 8-K Filing and other periodic filings made by the Company under the Exchange Act) or the NASD (other than pursuant to an
application for the listing of the Shares on the NASDAQ Stock Market), without the prior written consent of such Investor, except to the extent such disclosure is required by law or

 
NASD regulations, in which case the Company shall provide the Investors with prior notice of such disclosure. 

        8.5.
HSR Act Filing

        The
Company and WP shall, as soon as practicable after the date of this Agreement, but in no event later than April 3, 2005, file Notification and Report Forms under the HSR Act
with the Federal Trade Commission (the "FTC") and the Antitrust Division of the Department of Justice (the "Antitrust
Division") relating to the transaction contemplated by this Agreement and shall use their reasonable best efforts to respond as promptly as practicable to all inquiries
received from the FTC or the Antitrust Division for additional information or documentation; provided, however, that no such filing shall be made if, on
or before March 15, 2005 (or such later date as agreed upon by the Company), WP notifies the Company of its determination that such filing will not be required by applicable law. 

        8.6.
Insurance

        The
Company will use its best efforts to maintain all insurance, including without limitation directors and officers insurance, with responsible and reputable insurance companies or
associations in at least such amounts and covering such risks as the Company has previously maintained. 

SECTION 9. MISCELLANEOUS  

        9.1. Notices

        (a)   All
communications under this Agreement shall be in writing and shall be delivered by hand or facsimile or mailed by overnight courier or by registered mail or certified
mail, postage prepaid: 

        (1)   if
to an Investor, at the address or facsimile number set forth on Exhibit A, or at such other address or
facsimile number as such Investor may have furnished the Company in writing; and 

        (2)   if
to the Company, at: 11080 CirclePoint Road, Westminster, Colorado, 80020 (facsimile: (303) 426-4731), Attention: General Counsel, or at such other
address or facsimile number as it may have furnished the Investors in writing, with a copy (which shall not constitute notice) to Cooley Godward LLP, 380 Interlocken Crescent, Suite 900,
Broomfield, Colorado, 80021-8023 (facsimile: (720) 566-4099), Attention: Brent Fassett, Esq. 

        (b)   Any
notice so addressed shall be deemed to be given: if delivered by hand or facsimile, on the date of such delivery; if mailed by overnight courier, on the first
Business Day following the date of such mailing; and if mailed by registered or certified mail, on the third Business Day after the date of such mailing. 

        9.2.
Expenses and Taxes

        (a)   The
Company shall reimburse WP, within fifteen Business Days of such request by WP and in an amount not to exceed $250,000, all of WP's
out-of-pocket fees and expenses incurred in connection with the negotiation, preparation, execution and delivery of this Agreement and the transactions contemplated hereby,
including, without limitation, the fees and expenses of WP's attorneys, accountants and consultants employed in connection with WP's consideration, negotiation and consummation of the transactions
contemplated hereby, WP's due diligence on the Company and any documentation relating to the transactions contemplated hereby. 

        (b)   The
Company will pay, and save and hold each Investor harmless from any and all liabilities (including interest and penalties) with respect to, or resulting from any
delay or failure in paying, stamp and other taxes (other than income taxes), if any, which may be payable or determined to be payable on the execution and delivery or acquisition of the Shares or the
Exchange Shares.

 

        9.3.  Reproduction of Documents

        This
Agreement and all documents relating thereto, including, without limitation, (i) consents, waivers and modifications which may hereafter be executed, (ii) documents
received by the Investors on the applicable Closing Date (except for certificates evidencing the Shares themselves), and (iii) financial statements, certificates and other information
previously or hereafter furnished to the Investors, may be reproduced by the Company and the Investors by any photographic, photostatic, microfilm, micro-card, miniature photographic or
other similar process and the Company and the Investors may destroy any original document so reproduced. All parties hereto agree and stipulate that any such reproduction shall be admissible in
evidence as the original itself in any judicial or administrative proceeding (whether or not the original is in existence and whether or not such reproduction was made by the Company or any such
Investor in the regular course of business) and that any enlargement, facsimile or further reproduction of such reproduction shall likewise be admissible in evidence. 

        9.4.
Termination and Survival

        Notwithstanding
anything to the contrary contained herein, this Agreement may be terminated at any time (i) by mutual consent of the Company and the Majority Investors,
(ii) by either the Company or WP if the Initial Closing shall not have occurred on or prior to March 11, 2005 (unless such date is extended by mutual written consent); (iii) by
the Investors, for any material breach of this Agreement by the Company; and (iv) by the Company, for any material breach of this Agreement by the Investors. In the event of termination
pursuant to this Section 9.4, this Agreement shall become null and void and have no effect, with no liability on the part of the Company or the Investors, or their members, partners, directors,
officers, agents or stockholders, with respect to this Agreement, except for the (i) liability of the Company for expenses pursuant to Section 9.2 and (ii) subject to the
foregoing
sentence, liability for any breach of any representation, warranty or covenant contained in this Agreement. 

        9.5.  Successors and Assigns

        Except
as otherwise expressly provided herein, this Agreement shall inure to the benefit of and be binding upon the successors and assigns of each of the parties. The Company may not
assign its rights or obligations hereunder without the prior written consent of the Majority Investors. WP may assign its rights and obligations hereunder to not more than three (3) of its
members or Affiliates or Affiliates of its members; provided, that the assignee provides the Company with written representations and warranties
substantially similar to those provided in Section 4. 

        9.6.
Severability

        In
the event that any part or parts of this Agreement shall be held illegal or unenforceable by any court or administrative body of competent jurisdiction, such determination shall not
affect the remaining provisions of this Agreement which shall remain in full force and effect. 

        9.7.
Governing Law

        This
Agreement shall be governed by and construed in accordance with the laws of the State of Delaware applicable to contracts made and to be performed entirely within such State. 

        9.8.
Paragraph and Section Headings

        The
headings of the sections and subsections of this Agreement are inserted for convenience only and shall not be deemed to constitute a part thereof.

 

        9.9.  Limitation on Enforcement of Remedies

        The
Company hereby agrees that it will not assert against the limited partners of any members of any Investor any claim it may have under this Agreement by reason of any failure or
alleged failure by such Investor to meet its obligations hereunder. 

        9.10.
Counterparts

        This
Agreement may be executed in one or more counterparts (including by facsimile), each of which shall be deemed an original and all of which together shall be considered one and the
same agreement. 

        9.11.
Entire Agreement; Amendment and Waiver

        This
Agreement, the schedules and exhibits attached hereto constitute the entire understandings of the parties hereto and supersede all prior agreements or understandings with respect to
the subject matter hereof among such parties. This Agreement may be amended, and the observance of any term of this Agreement may be waived, with (and only with) the written consent of the Company and
the Majority Investors. 

[Signature Page to Follow.]

	

 	
 	

Very truly yours,
	

 	
 	
ALLOS THERAPEUTICS, INC.
	
 	
 	

By:	
 	

/s/  MICHAEL E. HART      
 Name: Michael E. Hart

Title: President and Chief Executive Officer

	
ACCEPTED AND AGREED:	
 	

 
	
WARBURG PINCUS PRIVATE EQUITY VIII, L.P.	
 	

 
	
By:	
 	

Warburg Pincus & Co., General Partner	
 	

 
	

By:	
 	

/s/  JONATHAN LEFF      
 Name: Jonathan Leff

Title: Partner	
 	

 

Counterpart Signature Page to Securities Purchase Agreement

(pursuant to Section 2.5)  

        IN WITNESS WHEREOF, the undersigned Investors have executed this Securities Purchase Agreement as of March 8, 2005. 

	

 	
 	
INVESTOR:
	
 	
 	
FrontPoint Healthcare Fund, L.P.
	

 	
 	

By:	
 	

FrontPoint Healthcare Fund GP, LLC, its General Partner
	

 	
 	

By:	
 	

/s/  ARTHUR J. LEV      

	 	 	Name:	 	Arthur J. Lev
	 	 	Title:	 	Authorized Signatory
	

 	
 	
INVESTOR:
	
 	
 	
FrontPoint Healthcare Horizons Fund, L.P.
	

 	
 	

By:	
 	

FrontPoint Healthcare Horizons Fund GP, LLC, its General Partner
	

 	
 	

By:	
 	

/s/  ARTHUR J. LEV      

	 	 	Name:	 	Arthur J. Lev
	 	 	Title:	 	Authorized Signatory

EXHIBIT A  

 SCHEDULE OF INVESTORS  

	Investor Name and Address
 
	 	Shares of Exchangeable Preferred Stock

	Warburg Pincus Private Equity VIII, L.P.

466 Lexington Avenue

New York, NY 10017

Facsimile: (212) 878-0850

Attention: Mr. Jonathan S. Leff	 	2,262,443
	

with a copy (which shall not constitute notice) to:

Willkie Farr & Gallagher LLP

787 Seventh Avenue

New York, NY 10019

Facsimile: (212) 728-9222

Attention: Steven J. Gartner, Esq.	
 	

 
	

FrontPoint Healthcare Fund, L.P.

80 Field Point Road

Greenwich, CT 06830

Facsimile: 203-622-5450

Attention: Arthur J. Lev	
 	

63,100
	

FrontPoint Healthcare Horizons Fund, L.P.

80 Field Point Road

Greenwich, CT 06830

Facsimile: 203-622-5450

Attention: Arthur J. Lev	
 	

26,900

EXHIBIT B

CERTIFICATE OF DESIGNATIONS  

EXHIBIT C

CERTIFICATE OF INCORPORATION  

EXHIBIT D

BYLAWS  

EXHIBIT E

FORM OF LEGAL OPINION  

EXHIBIT F

REGISTRATION RIGHTS AGREEMENT  

EXHIBIT G

STANDSTILL AGREEMENT  

EXHIBIT H

RIGHTS AMENDMENT  

QuickLinks

SECURITIES PURCHASE AGREEMENT

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00079-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00079-of-00352.parquet"}]]