Document:

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                      SUPPLY AND MANUFACTURING AGREEMENT

         Agreement, dated as of July 20, 2000 (the "Effective Date"), by and
between DRUGABUSE SCIENCES, INC. ("DAS"), a California corporation with offices
at 330 Distel Circle, Suite 150, Los Altos, CA 94022, and EON LABS
MANUFACTURING, INC. ("Eon"), a Delaware corporation with offices at 227-15 North
Conduit Ave., Laurelton, NY 11413.

         The Parties hereby agree as follows:

                                 ARTICLE I

                                DEFINITIONS

         1.1 "AFFILIATE" shall mean (a) any corporation directly or indirectly
controlling, controlled by, or under common control with (to the extent of fifty
percent (50%) or more of its issued capital entitled to vote for the election of
directors) a Party or (b) any partnership, joint venture or other entity
directly or indirectly controlled by, controlling, or under common control with
(to the extent of fifty percent (50%) or more of voting power or otherwise
having power to control its general activities) a Party, but in each case only
for so long as such ownership or control shall continue.

         1.2 "AGREEMENT" shall mean this Supply and Manufacturing Agreement, as
amended from time to time.

         1.3 "DELIVERY DATE" shall mean a date for which delivery of Product is
requested in a Purchase Order.

         1.4 "FDA" shall mean the United States Food and Drug Administration.

         1.5 "LOT QUANTITY" or "LOT QUANTITIES" shall [******], or such other
amounts as the Parties may agree to in writing from time to time.

         1.6 "NET MARGIN" shall mean revenue actually received by DAS for
Product sold by DAS, less discounts, rebates, shelf adjustments, stock
adjustments, returns for credit and including the price paid to Eon for the
Product, and transportation cost for Product shipped to DAS's distribution
center/warehouse.

         1.7 "PARTY" shall mean either Eon or DAS; "PARTIES" shall mean Eon and
DAS.

         1.8 "PRODUCT" shall mean [******] hereunder by Eon that meet the
Specifications.

         1.9 "PURCHASE ORDER" shall mean a firm order for Product submitted by
DAS to Eon.

         1.10 "REGULATORY AUTHORITY" shall mean the FDA or such other agency or
instrumentality of the United States to which the responsibilities of the FDA
are given or delegated.

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         1.11 "PRODUCT ANDA" shall mean the Abbreviated New Drug Application
approval issued to Eon by the FDA and designated as ANDA #75-434 (as defined
below) for the Product, including any amendments or modifications thereto.

         1.12 "SPECIFICATIONS" shall mean the specifications for Product
manufactured and delivered by Eon as set forth in Exhibit I hereto (as such
Exhibit may be amended by the Parties from time to time). The "PACKAGING
SPECIFICATIONS" for the Product are set forth in Exhibit I-A.

         1.13 "TABLETS" shall mean [******].

         1.14 "TERM" shall have the meaning set forth in Section 6.1 hereof.

         1.15 "TERRITORY" shall mean the United States of America and its
territories and possessions.

                                  ARTICLE II

                          SALE AND PURCHASE OF PRODUCT

         2.1 SALE AND PURCHASE. Eon agrees to manufacture and supply DAS such
Lot Quantities of Product as DAS may order pursuant to and in accordance with
this Agreement, for DAS's use, distribution and sale; PROVIDED, HOWEVER, that
DAS may only distribute and sell Product to customers located in the Territory.

         2.2 PURCHASE ORDERS.

         (a) All purchases of Product hereunder shall be made by Purchase
Orders, and shall be subject to the terms of this Agreement. No additional terms
may be imposed by a Purchase Order.

         (b) Each Purchase Order shall include the total amount of Product
ordered in Lot Quantities with a [******] and the required Delivery Date, which
shall be no less than [******] after the receipt by Eon of such Purchase Order.
DAS may specify any proportion of [******] and [******] in a Purchase Order. Eon
will confirm receipt of each Purchase Order within [******] days of receipt.

         2.3 EXCLUSIVITY. During the Term, [******] and [******]; provided,
however, [******] (and only under) [******].

         2.4 TABLET TOOLING. Eon will, through its usual and customary sources
and subject to DAS's prior written approval given on a case-by-case basis and at
DAS's cost, order appropriate tooling that meets DAS's specifications for use in
the production of the Product (the "TOOLING"), provided that such specifications
comply with the requirements of the Product ANDA. Eon shall use the Tooling to
produce the Product and Eon shall only use the Tooling to produce Product to be
sold to DAS. Eon shall, at its cost, validate, use and maintain the Tooling

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in accordance with its current standard operating procedures. Upon
termination of this Agreement, Eon shall, at DAS's option, either provide the
Tooling to DAS or destroy it.

         2.5 QUANTITY; FORECASTS. DAS shall deliver to Eon on a quarterly basis
during the Term a non-binding forecast of DAS quantity requirements for Product
for the following twelve (12) month period. Eon understands and agrees that DAS
forecasts are nonbinding until Purchase Orders are placed and that forecasts for
orders may be adjusted or cancelled by DAS in its sole discretion.

         2.6 MINIMUM PURCHASES. Subject to the terms and conditions of this
Agreement, DAS shall purchase a minimum of [******]. In the [******]. In each
[******] period thereafter during the Term, DAS [******].

         2.7 SHORTAGES. In the event there is inadequate [******] raw material
with which to manufacture all of the Product forecasted or ordered by DAS, Eon
shall immediately notify DAS of the shortfall and allocate the available supply
between DAS and Eon pro-rata based upon each Party's sales of Product over the
immediately preceding three (3) month period.

         2.8 MANUFACTURE/DELIVERY.

              (a) Eon shall manufacture the Product (i) according to the
Specifications, (ii) in compliance with all applicable FDA Good Manufacturing
Practices ("GMP"), the Federal Food, Drug, and Cosmetic Act (the "ACT"), and
all regulations promulgated under the Act, and (iii) in a GMP facility
inspected and approved by the applicable Regulatory Authority for the
manufacture of the Product. Eon shall provide DAS reasonable advance notice
before making any change to the Product manufacturing process that would
require notification to the FDA or any other Regulatory Authority. Eon will
inform DAS of any deviations from GMP procedures that may affect the quality,
potency or strength of the Product. If in the event that all or any of Eon's
GMP procedures that could effect the Product are or become the subject of an
investigation, inspection or other inquiry by a Regulatory Authority and such
investigation, inspection or inquiry results in the issuance of corrective
actions, warning letters or other notices (whether or not they require
immediate corrective action) related to GMP procedures for the Product, Eon
shall promptly inform DAS of such actions and provide DAS an opportunity to
review and consult with Eon regarding the situation and Eon's intended course
of action.

              (b) Eon shall package and label the Product in accordance with
the Packaging Specifications and the Product ANDA.

              (c) Eon shall ship Product in full Lot Quantities F.O.B. DAS's
designated facilities in accordance with DAS's instructions and no earlier
than three (3) days prior to the applicable Delivery Date, subject to the
commercial availability of the raw material [******]. DAS shall take title to
and risk of loss of each shipment of Product hereunder upon delivery to the
carrier of such shipment. For each lot of Product shipped to DAS, Eon will
send to DAS's offices copies of all applicable quality and testing records,
and any other documents reasonably required for DAS to demonstrate that the
Product conforms to all applicable Regulatory Authority requirements, which
shall be in a form reasonably acceptable to DAS. Eon shall prepay the freight
charges for each shipment of Product and add them to the appropriate invoice.

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         2.9 REJECTION OF PRODUCT IN CASE OF NONCONFORMITY.

              (a) DAS may reject any portion of any Lot Quantities that (i)
does not fully conform to the Specifications or (ii) is adulterated or
misbranded within the meaning of the Federal Food, Drug and Cosmetic Act. In
order to reject a shipment, DAS must (i) give notice to Eon of DAS's intent
to reject the shipment within fifteen (15) business days (i.e., a day on
which DAS and Eon are each open for business) of receipt together with a
written indication of the reasons for such possible rejection, and (ii) as
promptly as reasonably possible thereafter provide Eon with notice of final
rejection and the full basis therefor; provided, however, that in the case of
Product having a latent defect that could not have been discovered upon
reasonable examination, DAS must only give notice of its intent to reject
within five (5) business days after discovery of such defects. Eon shall
notify DAS within thirty (30) days after receipt of a rejection notice from
DAS as to whether it accepts DAS's basis for such rejection.

              (b) DAS shall be entitled to a refund of the purchase price
(together with freight charges) of properly rejected Product at the time it
is ultimately rejected by DAS, provided that if Eon disputes the rejection,
refund shall be made, if at all, at the time the dispute is finally resolved
as set forth in Article IV. Eon shall notify DAS within thirty (30) days
whether it accepts DAS's basis for any rejection.

              (c) Whether or not Eon accepts DAS's basis for rejection,
promptly on receipt of a notice of rejection, Eon shall use all diligent
efforts, at DAS's request, to provide replacement Product within sixty (60)
days after receipt of a rejection notice from DAS.

              (d) DAS shall return rejected Product to Eon at Eon's cost.

         2.10 STABILITY STUDIES AND RELATED TESTING. It is DAS's intention to
develop [******] for Product. In support of DAS, and at DAS's request, Eon shall
perform all applicable tests, release testing, and stability studies for the
Product for [******] specifications developed by DAS in accordance with the Eon
ANDA, as more specifically set forth in Exhibit III. DAS shall [******]
conducting such studies on [******].

                                  ARTICLE III

                                QUALITY DISPUTES

         3.1 PRODUCT QUALITY DISPUTES. If DAS rejects any Product and if the
Parties have not agreed mutually on a remedy, the Parties shall timely consult
with each other and attempt to resolve the discrepancies. If the Parties cannot
resolve the discrepancies in a timely manner, they shall promptly nominate an
independent, reputable laboratory, which shall carry out analyses with respect
to such Product as may be jointly agreed upon by Eon and DAS and at the Parties'
joint expense. The results obtained by the laboratory shall be binding on the
Parties for purposes of this Agreement.

         If the results conclude that the Product conformed to the
Specifications, DAS shall reimburse Eon amounts paid to the testing laboratory.
If the results conclude that the Product does not conform to the Specifications,
Eon shall reimburse DAS amounts paid to the

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laboratory. In the event the laboratory cannot conclude whether the Product
conforms or not to the Specifications, the Parties shall equally share the
laboratory expenses.

         3.2 NONPAYMENT FOR NONCONFORMING PRODUCT. If DAS rejects any Product
and the laboratory determines that such Product does not conform with the
Specifications, Eon shall at DAS's option either replace the nonconforming
Product as soon as reasonably possible (but no later than sixty (60) days) or
issue a refund therefor. In the event of refunds, the purchase price of such
Product (along with other applicable costs such as insurance and freight
charges) shall be promptly refunded to DAS.

                                  ARTICLE IV

                               PRICE AND PAYMENTS

         4.1 PRICE/PAYMENTS. DAS shall pay Eon the amounts set forth in Exhibit
II hereto for Product delivered by Eon pursuant to this Agreement. In addition,
DAS shall pay [******]: (a) [******] and (b) [******].

         4.2 METHOD OF PAYMENT. All payments for Product delivered to DAS by Eon
hereunder shall be [******] therefor.

         4.3 ROYALTIES. [******]. Beginning [******] after DAS has sold the
first Product, [******] (each a "Period"): (a) [******]; (b) [******], and (c)
[******] during such Period. [******] of the end of the [******] (each, a
[******].

         4.4 REPORTING AND ACCESS.

              (a) Within sixty (60) days after the end of each Quarter, DAS
shall provide Eon with reports indicating the total number of Tablets sold
during such Quarter, and reasonably detailed calculations of the
corresponding Net Margin. Such reports shall be subject to Eon's audit and
approval.

              (b) No more than once in any twelve (12) month period during
the term and for one (1) year thereafter, Eon shall be entitled to appoint an
independent auditor bound to confidentiality to audit, during regular
business hours and upon reasonable prior notice, DAS's relevant books and
records for the purpose of verifying the accuracy of the calculations of Net
Margin provided pursuant to Section 4.4(a) hereof. Eon shall bear the cost
and expense of any such audit, unless such audit shows underpayment by DAS by
more than five percent (5%), in which case DAS will bear the cost and expense
of such audit.

                                   ARTICLE V

                        QUALITY ASSURANCE/SAFETY/RECALLS

         5.1 QUALITY CONTROL. Eon agrees to keep DAS reasonably informed on
Product quality control and any other issues concerning the Product or the
manufacture thereof. The parties agree to discuss in good faith the appropriate
course of action with respect to any such

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issues. In the event of an inspection by the FDA or any other Regulatory
Authority that relates to the Product or the manufacture thereof, Eon shall
notify DAS within twenty (20) business days in writing of the details and
results of any such investigation.

         5.2 SAFETY/REGULATORY MATTERS. DAS shall give Eon notice within five
(5) business days of any complaints it receives regarding the Product. Eon shall
give DAS notice as described below of any confirmed complaints or other
information it receives regarding the safety of the Product, including any
information on adverse, serious or unexpected events associated with the use of
the Product. However, for serious, unexpected events, notice must be given by
telephone and fax to the appropriate representative of the other party
immediately after receipt of the information and followed by written notice not
more than one business day thereafter. Eon shall promptly inform DAS of any
environmental non-compliance or regulatory issues that could jeopardize Eon's
ability to manufacture, package and supply the Product hereunder. Eon shall
inform DAS's Vice President of Regulatory Affairs via telephone and fax within
two business days of receipt of any communication from the FDA or other
Regulatory Authority regarding the Product and will promptly furnish DAS with
copies of any such communication (including any notice, form, warning, report or
claim). Eon is responsible for reporting all adverse events to the appropriate
Regulatory Authority. Eon shall notify DAS prior to making any changes to the
Product label.

         5.3 RECALLS. If DAS reasonably decides to or is required to initiate a
Product recall, withdrawal or field correction with respect to, or if there is
any governmental seizure of, any Product supplied hereunder (collectively
"RECALL"), DAS shall notify Eon promptly of the details regarding such Recall,
and provide copies of all relevant documentation concerning such Recall. Eon
shall cooperate with and use all reasonable efforts to assist DAS in
investigating any such Recall. DAS will be responsible for coordinating any such
Recall, including providing appropriate notice to DAS's customers. All
regulatory contacts that are made and all other activities concerning seizure,
recall, withdrawal or field correction shall be coordinated by Eon in
consultation with DAS. If any such Recall arises substantially out of any act,
omission or fault of Eon (or its representatives or agents), Eon shall replace
all recalled Product on a timely basis at no cost or charge to DAS.

         5.4 INSURANCE. DAS agrees to maintain, throughout the term of this
Agreement for so long as it is commercially reasonable, [******] with a minimum
[******]. Eon agrees to maintain, throughout the term of this Agreement for so
long as it is commercially reasonable, [******] with a minimum of [******].

                                   ARTICLE VI

              TERMINATION, RIGHTS AND OBLIGATIONS UPON TERMINATION

         6.1 TERM. Unless otherwise terminated pursuant to Section 6.2
hereof, this Agreement shall begin on the Effective Date and continue in
effect thereafter for a period of five (5) years from the date Effective
Date. Thereafter this Agreement shall automatically renew for additional two
(2) years periods unless either Party gives written notice of intent to
terminate not less than one (1) year prior to the expiration of the then
current term (the initial term and any renewal terms shall be referred to
collectively as the "TERM").

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         6.2 TERMINATION. This Agreement may be terminated in its entirety by
either Party immediately upon the occurrence of any of the following events:

              (a) if the other Party entirely ceases to do business, or
otherwise completely terminates its business operations;

              (b) if the other Party breaches any material provision of this
Agreement and fails to cure such breach within sixty (60) days of receipt of
written notice describing such breach.

         6.3 RIGHTS AND OBLIGATIONS ON EXPIRATION OR TERMINATION. Except to the
extent expressly provided to the contrary, the following provisions shall
survive the termination of this Agreement: ARTICLE III, ARTICLE IV, ARTICLE V,
this Section 6.3, ARTICLE VII, ARTICLE VIII, and ARTICLE IX. Any rights of Eon
to payments accrued through the termination of this Agreement as well as
obligations of the Parties under firm orders for purchase and delivery of
Product at the time of such termination shall remain in effect, except that in
the case of termination under Section 6.2 hereof, the terminating Party may
elect whether obligations under firm orders shall remain in effect.

                                ARTICLE VII

                  COVENANTS; REPRESENTATIONS AND WARRANTIES;
                   INDEMNIFICATION; LIMITATION ON LIABILITY

         7.1 COVENANTS.

              (a) DAS covenants and agrees that:

                   (i) It will promote the sale and distribution of the
Product in a manner consistent with that employed by DAS in its promotion of
other products of similar character, and shall use diligent efforts to
facilitate the initiation of the sale of the Product;

                   (ii) During the Term it will not [******]; and

                   (iii) It will comply with all applicable local, state or
federal rules, regulations, statutes and laws (collectively, "LAWS") in
promoting, marketing, distributing and selling the Product.

              (b) Eon covenants and agrees that:

                   (i) All Product shall, [******] after the date of delivery
of such Lot Quantity to DAS (i.e., that Product performance/potency/efficacy
during the entire shelf life period shall comply with the Specifications);

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                   (ii) Product shall be registered with the State Boards of
Pharmacy in all states, territories and possessions of the United States
where such registration is required to market the Product, within six months
of the Effective Date;

                   (iii) The Product will be manufactured, packaged, stored
and shipped in conformance with all applicable GMP's;

                   (iv) The Product will be manufactured, packaged and stored
in facilities which are approved by the FDA at the time of such manufacture,
packaging and storage, to the extent such approval is required by Law;

                   (v) Eon has obtained and will maintain and comply with all
licenses, permits and approvals of applicable governmental agencies as may be
required for Eon's facility and to manufacture, package, store and ship the
Product; and

                   (vi) Eon will have sole responsibility for adopting and
enforcing safety procedures for the manufacture, packaging, storage, and
shipment of Product at Eon's facility.

         7.2 REPRESENTATIONS AND WARRANTIES.

              (a) Eon hereby represents and warrants that: (i) the
manufacture, use and/or sale of the Product does not infringe any patent,
trademark, trade secret or other intellectual property or proprietary right
of any third party; (ii) it has full authority to enter into this Agreement
and has all rights and licenses necessary to manufacture and sell the Product
to DAS; (iii) there is nothing contained in any other agreements to which Eon
is a party which prohibits or restricts Eon from entering into this
Agreement; (iv) Eon is licensed to sell the Product in all states,
territories and possessions of the United States where licensure is required
for sale; and (v) Eon shall maintain the Product ANDA in accordance with all
applicable laws and regulations.

              (b) DAS hereby represents and warrants that: (i) it has full
authority to enter into this Agreement and has all rights and licenses
necessary to market, distribute and sell the Product; and (iii) there is
nothing contained in any other agreements to which DAS is a party which
prohibits or restricts DAS from entering into this Agreement.

         7.3 INDEMNIFICATION.

              (a) Each Party hereby [******].

              (b) The foregoing indemnity obligations are conditioned upon
the Indemnified Party providing the Indemnifying Party (a) prompt notice of
any claim, proceeding or suit, (b) sole control of the defense and settlement
of any such claim, proceeding or suit, and (c) reasonable cooperation, at the
Indemnifying Party's expense, in connection with the defense of the matter
subject to indemnification. The Indemnifying Party shall keep the Indemnified
Party fully informed as to the progress of the defense and any proposed
settlement, and the Indemnifying Party shall furnish the Indemnified Party
with copies of all litigation and settlement papers in connection therewith.
The Indemnified Party shall have the right to

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participate (subject to the control of the Indemnifying Party), at its own
cost and expense and through counsel selected by it, and subject to court
approval, in the defense of any such claim.

         7.4 LIMITATION ON LIABILITY. EXCEPT FOR EITHER PARTY'S INDEMNIFICATION
OBLIGATIONS AS SET FORTH ABOVE, IN NO EVENT SHALL EITHER PARTY BE LIABLE TO THE
OTHER FOR ANY SPECIAL, INCIDENTAL, CONSEQUENTIAL OR INDIRECT DAMAGES ARISING IN
ANY WAY OUT OF THIS AGREEMENT.

                                  ARTICLE VIII

                             PROPRIETARY INFORMATION

         8.1 Each Party agrees that it (i) shall treat and maintain as
confidential, (ii) shall not use (except as contemplated by this Agreement and
then only on a confidential basis), and (iii) shall not disclose, in whole or in
part, to any third party (other than such Party's agents, officers, employees
and consultants (collectively, "REPRESENTATIVES") to whom disclosure is
permitted under paragraph 8.2) any information received from the other Party in
connection with this Agreement that is marked or identified as confidential or
proprietary information at or before the time of disclosure (all such
information being hereinafter referred to as "PROPRIETARY INFORMATION").

         8.2 The provisions of Section 8.1 shall not apply to any Proprietary
Information which the receiving Party can show (i) was in the public domain at
the time of its receipt, (ii) is published or otherwise becomes, after its
receipt thereof, a part of the public domain other than by reason of any of the
receiving Party's acts or omissions (but only after, and only to the extent
that, it is published or otherwise becomes part of the public domain), (iii) has
been put in the receiving Party's possession or knowledge (as evidenced by
written records), prior to the time of its receipt thereof from the other Party,
by any third party or by employees of the receiving Party (acting directly or
indirectly for or on its behalf) as a matter of right and without restriction on
use or disclosure, (iv) was in the receiving Party's possession or knowledge (as
evidenced by written records) prior to the date of this Agreement, (v) is
developed by the receiving party independently of any disclosure received by the
disclosing party, as evidenced by contemporaneous written records, or (vi) is
required to be disclosed by the receiving Party pursuant to FDA regulations, law
or judicial order, provided that, in such event, the receiving party shall
notify the disclosing party promptly so that the disclosing party may seek a
protective order.

         8.3 The Parties shall restrict the Proprietary Information to their
Representatives who are directly involved in the performance of this Agreement
to the extent that they have need of such, and then only on a confidential
basis. The receiving party shall be responsible for the breach of this ARTICLE
VIII by it or any of its Representatives.

         8.4 The Parties acknowledge and agree that damages from a material
breach of this ARTICLE VIII shall be difficult or impossible to ascertain, and
further agrees that the other Party may therefore enforce the provisions of this
ARTICLE VIII by seeking preliminary and/or permanent injunctive relief.

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                                   ARTICLE IX

                                  MISCELLANEOUS

         9.1 FORCE MAJEURE. No failure or omission by a Party in the performance
of any obligation under this Agreement shall be deemed a breach of this
Agreement or create any liability if such failure or omission shall arise from
any cause or causes beyond the reasonable control of such Party which cannot be
overcome through due diligence, including, but not limited to, strikes, riots,
war, acts of God, invasion, fire, explosion, floods, delay of carrier,
unexpected shortage or failure in the supply of raw materials, energy shortage
and acts of government or governmental agencies or instrumentalities. The Party
affected by any such event shall keep the other Party informed of the status
thereof and shall use diligent efforts to overcome such event.

         9.2 ENTIRE AGREEMENT. This Agreement contains the entire agreement of
the Parties regarding the subject matter hereof and supersedes all prior
agreements, understandings and negotiations regarding the same. This Agreement
may not be changed, modified, amended or supplemented except by a written
instrument signed by both Parties.

         9.3 ASSIGNABILITY. This Agreement may not be assigned by either Party
without the prior consent of the other Party (and any attempt to do so shall be
void); provided, however, that either Party may assign this Agreement to any
entity that acquires substantially all of its stock, assets or business.

         9.4 SEVERABILITY. If any provision of this Agreement shall be held
illegal or unenforceable, that provision shall be limited or eliminated to the
minimum extent necessary so that this Agreement shall otherwise remain in full
force and effect and enforceable.

         9.5 FURTHER ASSURANCES. Each Party agrees to execute, acknowledge and
deliver such further instruments, and to do all such other acts as may be
necessary or appropriate to carry out the purposes and intent of this Agreement.

         9.6 NOTICE AND REPORTS. All notices and other communications hereunder
and all legal process in regard hereto shall be validly given, made or served if
in writing, (i) on the date delivered, if delivered personally (by courier
service or otherwise) or via confirmed facsimile, (ii) on the business day after
the date sent, if sent by nationally recognized overnight courier service using
its highest priority service, or (iii) four (4) days after the date sent, if
mailed by first-class registered mail, postage-prepaid and return receipt
requested, to the address of the Party to receive such notice or other
communication set forth below, or at such other address as any Party may from
time to time advise the other Party pursuant to this Section 9.6:

           To Eon:                   Eon Labs Manufacturing, Inc.
                                     Attn: Chief Executive Officer:
                                     227-15 North Conduit Avenue
                                     Laurelton, NY 11413
                                     Tel: (718) 276-8699
                                     Fax: (718) 949-3120

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           To DAS:                   DrugAbuse Sciences, Inc.
                                     Attn:  Chief Executive Officer
                                     330 Distel Circle, Suite 150
                                     Los Altos, CA  94022
                                     Tel:  (650) 417-2300
                                     Fax:  (650) 417-2400

         9.7 RELATIONSHIPS OF THE PARTIES. The relationship between the Parties
is that of independent contractors. Neither Party is an agent, partner or
employee of the other Party and neither Party has any right or any other
authority to enter into any contract or undertaking in the name of or for the
account of the other Party or to assume or create any obligation of any kind,
express or implied, on behalf of the other Party, nor will the act or omissions
of either create any liability for the other Party. The Agreement shall in no
way constitute or give rise to a partnership between the Parties.

         9.8 WAIVER. The waiver by either Party of a breach of any provisions
contained herein must be in writing and shall in no way be construed as a waiver
of any subsequent breach of such provision or the waiver of the provision
itself.

         9.9 GOVERNING LAW. This Agreement shall be governed by and construed
pursuant to the laws of the State of New York, without regard to conflict of
laws provisions thereof.

         9.10 CAPTIONS. Paragraph captions are for convenience only and in no
way are to be construed to define, limit or affect the construction or
interpretation hereof.

         9.11 COUNTERPARTS. This Agreement may be executed in counterparts, each
of which shall be deemed an original, but all of which together shall constitute
one and the same instrument.

         IN WITNESS WHEREOF, the Parties have executed this Agreement to be
effective as of the date first written above.

                                 Eon Labs Manufacturing, Inc.

                                 By:    /s/ Frank Dellafera  7/25/00
                                    ---------------------------------------
                                 Title: V.P. Sales & Marketing
                                       ------------------------------------

                                 DrugAbuse Sciences, Inc.

                                 By:    /s/ Elizabeth Greetham  7/31/00
                                    ---------------------------------------
                                 Title: CFO and Sr. VP Business Development
                                       ------------------------------------

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                                    EXHIBIT I

                             PRODUCT SPECIFICATIONS

A.       TABLETS

         Tablets shall be produced utilizing [******].

B.       PRODUCT SPECIFICATIONS

         All Product supplied by Eon will meet all applicable specifications
         approved by the FDA or other Regulatory Authority and will continue to
         meet such specifications up through the Product expiration date.

<PAGE>

                                  EXHIBIT I-A

                            PACKAGING SPECIFICATIONS

The Product shall be packaged and labeled in accordance with mutually agreed
upon specifications and Eon's ANDA in [******] Tablets. The [******] a child
resistant closure.

<PAGE>

                                   EXHIBIT II

                                     PRICING

The sales price to DAS will be Eon's [******] as calculated following Generally
Accepted Accounting Principles [******]. Generally Accepted Accounting
Principles utilized are to be consistent with those used internally by Eon to
determine cost of their other products.

As the date of signing this contract Eon's cost and DAS's purchase price are as
follows:

<TABLE>
<CAPTION>
                                                                                DAS
                                            EON'S COST                   PURCHASE PRICE
<S>                                         <C>                          <C>
         Bottles of 30 tablets                   $ [******]                     $ [******]

         Bottles of 100 tablets                  $ [******]                     $ [******]
</TABLE>

DAS's purchase price [******] may be added to DAS's purchase price.

The [******], when Eon performs [******]. Except in conjunction with a general
updating of its standards, Eon will not be required to [******]. DAS will be
notified of the [******].

Eon's cost and DAS's purchase price will be [******].

Cost of the Product as determined under Generally Accepted Accounting Principals
include [******]. Indirect costs include but are not limited to [******], etc.

Costs from the following departments are to be excluded in determining Eon's
cost of the Product:  [******].

Eon will permit DAS duly authorized certified public account, to whom Eon has no
reasonable objection to inspect the books and records of Eon for up to two prior
years at reasonable times during regular business hours for the purpose of
verifying Eon's cost of the Product. Such accountants shall treat any
information obtained from Eon as confidential and will disclose to DAS only
whether Eon's costs have been verified.

In the event that the certified public accountant engaged by DAS and Eon do not
agree on the cost of the Product, a mutually agreed upon certified public
accountant will be engaged. The decision of the mutually agreed upon certified
public accountant will be binding on both parties. The cost of the mutually
agreed upon certified public accountant will be shared equally regardless of
their decision.

<PAGE>

                                   EXHIBIT III

                                   CMC STUDIES

Eon shall be responsible for receiving FDA approval of Product produced or
packaged with any new tooling or packaging formats. Eon will be responsible for
conducting all [******]. In the event that DAS would like to introduce an
[******], Eon will be responsible for conducting any [******].<PAGE>

                                                                 Exhibit 10.21

                                COMMERCIAL LEASE

       IN ACCORDANCE WITH THE TERMS OF DECREE N(DEGREE) 53-960 OF 30TH
                       SEPTEMBER 1953 AND ITS AMENDMENTS.

BY AND BETWEEN THE UNDERSIGNED

FINANCIERE E.T.S. having its registered office at 24 Avenue du lieutenant
Chassagne, 78620 L'etang-la-ville, represented by Mrs ROUGET, its Chairman, duly
authorised for the purposes of the presents.

Hereinafter referred to as "THE LESSOR"

AND:

DRUGABUSE SCIENCES, having its registered office at 166 boulevard du
Montparnasse, in Paris (75014), represented by Mrs Maryvonne HIANCE, its
Managing Director, duly authorised for the purposes of the presents.

Hereinafter referred to as "THE LESSEE"

THE FOLLOWING HAS BEEN NEGOTIATED AND AGREED UPON:

The lessor hereby agrees to let the premises described hereinafter, which make
up a (IL MANQUE UN MOT) of which it is the owner, to the lessee who accepts
this.

<PAGE>

                                                                            2

ARTICLE I - DESCRIPTION

1.       On the ground floor of a residential building located at 48-50 RUE
         BOISSONNADE - PARIS 14TH, a surface area for use as commercial premises
         and for business activities of approximately 220 M2 AND TWO UNDERGROUND
         PARKING PLACES.

         the aforementioned premises exist and consist of the elements described
         hereinabove, with no exception and without prejudice, and without any
         further description being required at the express request of the lessee
         who hereby declares that it is familiar with the premises having seen
         and visited them pursuant to the presents.

ARTICLE II - PURPOSE - AUTHORISATIONS

The lessee is hereby bound to use the rented premises for the purposes provided
for in this lease, to the exclusion of any other purpose of any nature,
importance and term whatsoever, under penalty of the immediate termination of
this lease, should the lessor see fit.

The contractual purpose described hereinabove shall in no way imply any form of
guarantee from the lessor concerning the respect for any required authorisation
or administrative regulation, of any nature whatsoever, for the performance of
all or part of the aforementioned activities.

As a result, the lessee shall ensure, at its own expense, risk and danger, that
it obtains any required authorisation, as well as ensuring the payment of any
sums, fees, duties, taxes or rights whatsoever relating to the business
activities carried out in the rented premises and to the usage of the premises.

ARTICLE III - TERM

The present lease is entered into for a term which shall begin on 1ST FEBRUARY
2000.

The lessee may terminate the lease at the end of each three year period
according to the conditions provided for by the effective regulations.

ARTICLE IV - RENT

1.       The present rental is agreed to and accepted in consideration of a
         yearly rent, in principal and exclusive of taxes of 242,000 FRENCH
         FRANCS (TWO HUNDRED AND FORTY-TWO THOUSAND FRANCS) which the lessee
         hereby undertakes to pay with the related VAT, on a quarterly basis and
         in advance. The quarters shall commence on first January, first April,
         first July and first October.

         Nevertheless, and exceptionally, the lessor shall grant an exemption
         from rent to the lessee for a period of 5 MONTHS from 1ST FEBRUARY 2000
         to 30TH JUNE 2000, making the first rental payment due on 1ST JULY
         2000. THE SERVICE CHARGES SHALL REMAIN PAYABLE DURING THIS PERIOD.

<PAGE>

                                                                            3

         Any sums which may be owed by the lessee to the lessor; rent, service
         charges and reimbursements of any nature whatsoever shall be paid by
         cheque or by direct debit from the lessee's bank account.

         Any delay in payment shall give rise, by rights, to the payment of
         interest at 10% per month, to remain effective until full payment has
         been made and which shall be added to the rent for the following
         quarter, without hindering the application of the provisions of article
         XIII "Avoidance Clause".

2. TAX ARRANGEMENTS: VAT

3. PRICE SOURCES

The rent shall be index-linked on a yearly basis and for the first time, on the
anniversary of the effective date of the lease, that is to say the 1st February
2000. The base index shall be the last published INSEE index - J.O. publication
- at the date of entry into the premises, that is to say the index from the 3rd
quarter of 1999 (1080). The price source shall be the index from the same
quarter of the year preceding the year when the revision is taking place.

ARTICLE V - SECURITY DEPOSIT

In support of this present lease, the lessee shall deposit, with the lessor, who
shall provide a receipt, a sum of: 60,500 FRENCH FRANCS (SIXTY THOUSAND FIVE
HUNDRED FRANCS) CORRESPONDING TO THREE MONTHS OF PRINCIPAL RENT.

This deposit is paid as security for the payment of the rent and the ancillary
service charges, as well as the correct performance of the clauses of the lease.

This sum shall be retained by the lessor during the whole term of the lease,
until the final payment of any indemnity which may be owed by the lessee to the
lessor at the expiry of the lease and its departure from the rented premises.
Under no circumstances may the final months rent be set off against this
security. This sum shall not generate any interest.

Where the lease is terminated as a result of the non-performance of the
conditions or for a reason which may be attributed to the lessee, this security
deposit shall become the property of the lessor as primary damages without
prejudice to any other damages.

This deposit must always be the equivalent of three months rent and shall be
increased or reduced in the same proportion as the rent by applying
article IV - 3, "Sliding Scale Clause" hereinabove.

ARTICLE VI - OBIGATIONS AND CONDITIONS

In addition, the present lease is agreed to and accepted according to the
following obligations and conditions, which the lessee undertakes to carry out
and accomplish without exception:

1.       The lessee shall accept the premises in their condition at the date of
         entry into possession, without being able to request that the lessor,
         at any time whatsoever during

<PAGE>

                                                                             4

         the term of the lease, carry out any repairs, improvements or
         replacements whatever their cause, nature or importance may be or
         reduce the rent in this respect.

2.       The lessee undertakes to maintain the rented premises in a good state
         of rental repair during the whole term of the lease and to carry out,
         where necessary, any repairs whatsoever, be they minor or major, with
         the exception of those provided for by article 606 of the French Civil
         Code, in such a way that the premises be handed back, at the end of the
         possession term, in a perfect state of repair and maintenance.

         The lessee further undertakes to maintain and replace, at its expense
         and whatever the nature of the work and repairs may be (even where they
         are obsolete), all installations, piping, apparatus, locks and more
         generally all the elements fitting out or making up the rented
         premises, without exception.

         The lessee hereby accepts that where it has failed to carry out the
         maintenance, repair or replacement work for which it is responsible
         itself, the lessor shall undertake, 30 days after sending a registered
         letter with acknowledgement of receipt and where this letter has
         produced no effect, and where the work is not of an urgent nature, to
         carry out the aforementioned services and work in its place. The lessee
         undertakes to reimburse the effective price, including all related
         expenses and fees, within fifteen days of receiving the statement which
         shall be sent by the lessor.

         The same shall apply to any works which may be carried out on the
         public highway or in neighbouring buildings which may give rise to a
         disturbance of possession for the lessee.

3.       The rented premises must be correctly managed and returned in a good
         state of maintenance and repair at the end of the rental period. The
         lessor must be immediately informed of any degradation or deterioration
         of the rented premises.

4.       The rented premises must be permanently fitted out with furniture,
         household effects, merchandise and valuable materials of a sufficient
         quantity to ensure, at any time whatsoever, the payment of rent and the
         performance of the obligations and conditions of the present agreement.

5.       The lessee may not carry out any construction or installation in the
         rented premises, nor any development, drilling of walls or change in
         the layout and generally, it may not make any modification whatsoever
         to these premises nor to their existing installations without having
         obtained the prior, express and written authorisation of the lessor.
         Where this authorisation is granted, all the works ordered by the
         lessee shall be done so under its own responsibility, risk and danger.
         The lessor's architect or a supervisory body duly appointed by the
         lessor shall be responsible for verifying that the work carried out
         does not negatively affect the appearance and solidity of the building
         and has not caused a reduction in its value, with their fees being
         settled by the lessee.

6.       At the expiry of the present lease, by an amendment to the agreed term
         or by termination for any reason whatsoever, all constructions and
         installations, all developments, improvements and embellishments made
         by the lessee shall remain,

<PAGE>

                                                                             5

         without indemnity, the property of the lessor, unless the latter
         should request that all or part of the premises be returned to their
         original state, whilst, in addition, reserving the right to choose
         between the material execution of the required work or a financial
         indemnity equivalent to their cost, an indemnity which constitutes a
         senior debt, in the same way as the rent. Where it is necessary to
         carry out remedial work, this work shall be carried out under the
         supervision of the lessor's architect, at the expense of the lessee.

7.       From the date of entry into possession, the lessee shall settle, in
         full, all taxes, contributions and charges, either existing or to be
         created, relating to the rented premises, notably sweeping, lighting,
         police and road fund taxes, as well as business tax. The lessor shall
         remain responsible for the payment of the rates.

8.       The lessee shall take out all subscriptions for water, electricity and
         telephone, and shall pay, on a regular basis, the subscriptions, rental
         of meters and consumption at their exact due date, in such a way as to
         ensure that the lessor never becomes involved in this respect. It may
         not demand any indemnity or reduction in rent from the lessor in the
         event of an interruption or cessation in the supply of water or
         electricity or in the operation of the telephone, for any reason
         whatsoever.

9.       The lessor shall make telephone lines available to the lessee who
         undertakes to return them to the lessor at the end of the lease, the
         lessee remaining responsible for the payment of the rent, charges and
         subscriptions during the entire term of the lease.

10.      The lessee undertakes to refrain from disturbing the tranquillity and
         peaceful possession of the neighbours, both during deliveries and
         during movements of personnel. The lessee hereby declares to be bound
         by the obligations of the rules of joint ownership and/or the rules of
         procedure.

11.      In relation to the public authorities, the lessee shall respect all the
         legal and regulatory formalities, whether they be already prescribed or
         recently prescribed, relating to its occupation and operations and it
         shall obtain, under the same head, the required administrative
         authorisations, in such a way as to ensure that the lessor shall not be
         implicated in this respect, the latter shall not incur any liability in
         the event of a refusal or delay in obtaining these new authorisations.
         It shall arrange and remain responsible for, at its own expense, risk
         and danger, all the work, developments and constructions which may be
         already prescribed or recently prescribed as a result of legislation or
         any regulation whatsoever, notably relating to protection of the
         environment, hygiene or security in workshops, shops and offices, in
         such a way as to ensure that the lessor never becomes involved in this
         respect.

12.      Whatever the case may be, the lessee may not in any way modify the
         outward appearance of the building by making additions to the facade or
         to elements of decor which are visible from the outside without the
         written agreement of the lessor and without prejudice to the constant
         stringent respect for any related effective regulations.

13.      In the event of compulsory surrender for a public purpose, nothing may
         be claimed from the lessor as all the lessee's rights shall be reserved
         against the expropriating party.

<PAGE>

                                                                             6

ARTICLE VII - TAXES, DUTIES AND CHARGES

The lessee undertakes to settle all town, police and road fund taxes or any
other national, regional, departmental, municipal or other taxes whatever the
nature of these taxes may be, in such a way as to ensure that the lessor never
becomes involved in this respect and, notably, to settle all the head tax and
occupancy contributions, rental tax, business tax. In particular, the lessee
must reimburse the tax on offices (approximately 74 Francs per m2 per year).

The settlement by the lessee of the service charges shall be made by the payment
of an on-account payment calculated on a quarterly basis in relation to the
previous charges, these on-account payments shall be applied against the actual
charges which are calculated on a yearly basis. In respect of the first quarter
of the rental period, the on-account payment is hereby fixed at 9,000 FF:

In the event that at the end of a quarter, the on-account payment which has been
made is found to be inferior to the previous charges, the lessee undertakes to
reimburse, at the lessor's first request, all sums which may be found to be
necessary to counter-balance the amount of the actual charges.

Where, at the year-end, the on-account payments which have been made are found
to be inferior to the actual charges, the lessee undertakes to reimburse, at the
lessor's first request, all sums which may be found to be necessary to
counter-balance the total amount of the actual charges. Any over-payment shall
be applied against the on-account payments for the current year.

ARTICLE VIII - INSURANCE

The lessee shall be responsible for:

a)       reimbursing the lessor, for a sum proportional to the premises which
         are the subject of the present lease in relation to the whole building,
         for the insurance premiums which the lessor shall have been obliged to
         pay in order to take out an insurance policy for the building against
         fire and any other destructive events, as well as any other risks which
         are generally insured.

         The reimbursement of the aforementioned premium, in the abovementioned
         proportions, shall take place at the date which shall be indicated by
         the lessor. Any sums which are payable by the lessee pursuant to this
         clause shall be considered as "rental charges" relating to the rented
         premises and may be recovered as rent through any of the legal
         channels.

b)       taking out insurance for the whole term of the lease for all the
         developments which it may make to the rented premises and for all the
         objects with which the rented premises are fitted out against the risk
         of fire, explosion and water damage, without exception, with a
         recognised solvent insurance company, having its registered office or a
         subsidiary in France. Insuring itself for the same risks against claims
         from third parties or neighbours.

<PAGE>

                                                                             7

         Refraining from and guaranteeing that its insurance company refrains
         from any recourse against the lessor.

         Insuring itself against any disturbance which may be caused by a third
         party to its possession either by flagrantly illegal action or
         otherwise. It is hereby agreed that the special risks relating to the
         lessee's business activities must be notified to the lessor company and
         that the possible extra premium, both for the lessor and the other
         occupants of the building, shall be settled in total by the lessee.

         Settling, on a regular basis, at their due date, the premiums relating
         to the aforementioned policies.

         Justifying, at the lessor's first request, performance of the clauses
         hereinabove by producing the policies and the receipts for the premiums
         relating thereto.

         Immediately informing the lessor by registered letter of any damage,
         under penalty of remaining personally liable for the damage whose cost
         could not have been, as a result of an omission or delay in this
         declaration, usefully claimed from the company insuring the building.

c)       Insuring its civil liability, for taking out all insurance and using
         any direct recourse as a result of theft or deteriorations which itself
         or its vehicles may suffer, the lessor hereby declares in accordance
         with article 1725 of the French Civil Code, that it shall not guarantee
         the lessee against any disturbance which may be caused by a third party
         to its possession and refuses any responsibility for accidents of any
         nature which may happen to the garaged vehicles, insuring its
         deprivation of possession and loss of operational capacity.

ARTICLE IX - LIABILITY - RECOURSE

The lessee hereby expressly undertakes to refrain from any recourse for
liability against the lessor:

a)       in the event of theft, burglary, or any criminal or punishable act of
         which the former may be the victim in the rented premises or in the
         outbuildings of the building;

b)       in the event of the modification or removal of the arrangements for
         guarding the building;

c)       in the event that rented premises happen to be destroyed, either
         totally or partially, by obsolescence, construction fault, act of God,
         or any other act which is independent of the will of the lessor, the
         present lease shall be terminated by rights and without indemnity;

d)       in the event of an interruption, even prolonged and for any reason
         whatsoever, in the supply of water, gas, electricity, heating, the lift
         and more generally in any source of energy or fluid whatsoever;

<PAGE>

                                                                             8

e)       in the event of the occurrence of a disturbance in the possession of
         the lessee as the result of a fault by a third party, whatever capacity
         they may be acting in, the lessee must act directly against the latter
         without having any claim against the lessor.

         The lessee undertakes to do nothing which may cause a disturbance in
         possession to the other occupants of the building or the neighbourhood.
         It undertakes to substitute for the lessor in any legal proceedings
         which may be initiated in this respect.

f)       in the event of flooding as a result of blocked drains, humidity,
         infiltration, leaks, the lessor shall under no circumstances be liable
         for damaged merchandise or any other damage.

ARTICLE X - ASSIGNMENT - SUB-LETTING

The lessee may not assign, under any form whatsoever, its rights under the terms
of the present lease without the express and written agreement of the lessor,
unless it is to the party acquiring its business whilst remaining the warrantor
and remaining jointly and severally liable for its assignee, both for the
payment of rent and for the performance of all the clauses, obligations and
conditions of the present lease. A registered original or an engrossed copy of
the lease assignment must be given to the lessor free of charge, during the
month of the assignment, under penalty of the aforementioned assignment being
declared null and void.

In the event of bankruptcy or rule of court, the assignment of the right to the
lease by the receiver, the debtor assisted by the receiver or the company's
inspector, may only be carried out under the conditions described in the first
paragraph of the present article.

The lessee may not sublet all of part of the premises which are the subject of
the presents, without the express and written agreement of the lessor. Whatever
the case may be, in the event of an authorised sub-lease, the lessee shall
remain solely responsible for the payment of all the rent to the lessor, and
solely responsible for the obligations and conditions of the present lease, the
possible sub-lease only being fully valid pursuant to the rights held by the
lessee as a result of the presents, the parties hereby expressly covenant that
the rented premises constitute an indivisible whole.

As a result of the above, the sub-lease shall be agreed to by the lessee at his
own risk and danger, the former undertaking to be personally responsible for
evicting any sub-tenant.

ARTICLE XI - VISITS AND RESTITUTION OF THE PREMISES

1. The lessee undertakes to allow the lessor, its representatives, architects,
contractors and workmen to enter the rented premises to monitor their state, to
take any urgent measures and to carry out any work as well as to allow visits
with a view to renting or selling the premises.

Under this head, the lessor may affix, on/or in the rented premises, any notice
or sign indicating that the aforementioned premises are for rent or sale.

2. At the expiry date of the present lease, for any cause or any reason
whatsoever, an inventory of fixtures shall be drawn up which shall consist,
notably, of the statement of

<PAGE>

                                                                            9

repairs, reconditioning and maintenance obligations which have not been
carried out by the lessee. The cost shall be calculated by the lessor's
architect to whom the contracting parties hereby grant an irrevocable
mandate. This cost shall be paid by the lessee to the lessor at the date of
the drafting of the aforementioned statement.

ARTICLE XII - CONCESSIONS - AMENDMENTS

The presents constitute the entire agreement made between the parties relating
to the present lease and cancel and replace any prior agreement whether written
or verbal relating either directly or indirectly thereto.

Any amendments to the presents may only be made by a written or bilateral
document.

Such an amendment may under no circumstances be set off against either the
concessions or the passivity of the lessor, the former remaining free to demand
at any time and without notice respect for and the full application of the
clauses and conditions of the present lease.

ARTICLE XIII - AVOIDANCE CLAUSE

In the absence of the payment at the due date of a single rental payment or the
performance of any one of the clauses of this contract and following a simple
summons for payment or formal notice communicated by an extra judicial
instrument which are ineffective, and expressing the wish of the lessor to take
advantage of this clause, the lease shall be immediately terminated by rights,
without the requirement to complete any legal formality and notwithstanding any
subsequent proposals or deposits.

Where, in breach of the terms of this clause, the lessee refuses to immediately
leave the premises, it shall be obliged to do so by the enforcement of an order
made by the Presiding Judge of the Court of First Instance having jurisdiction
or by any other jurisdiction ruling by interim proceedings for provisional
enforcement notwithstanding any appeal, who, after having noted the cancellation
of the lease, shall pronounce the immediate expulsion of the lessee. In
addition, a monthly and indivisible occupation indemnity, equal to the value of
one quarter of the annual instalment of the rent effective at that time, shall
be owed to the lessor.

This provision constitutes an essential and determining condition of this lease,
without which it would not have been granted.

ARTICLE XIII - ELECTION OF DOMICILE

For the purposes hereof, each of the parties elect domicile at their respective
registered offices.

Dated in Paris on February 1, 2000.

                                    Made in,
                               In three originals
                                       On

THE LESSEE                                                   THE LESSOR

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