Document:

Sublease Agreement, dated 5/30/05, between the Registrant and Salix Pharm.

 Exhibit 10.7 
 CONSENT TO SUBLEASE 
  
 THIS CONSENT TO SUBLEASE (“Consent”) is made and entered into as of the 30 day of May, 2005 (the “Effective Date”), by and among COLONNADE DEVELOPMENT LLC, a Delaware limited liability company (“Landlord”),
SALIX PHARMACEUTICALS, INC., a California corporation (“Tenant”) and VOYAGER PHARMACEUTICAL CORP., a Delaware corporation (“Subtenant”). 
  
 WHEREAS, Tenant and Landlord entered into that certain Lease Agreement dated June 30, 2000, as amended by a First Amendment to Lease dated September 9,
2004 and as partially assigned by that Assignment and Assumption of First Amendment to Lease dated September 9, 2004 (collectively, the “Lease”), whereby Landlord has leased to Tenant and Tenant has leased from Landlord approximately
26,363 rentable square feet on the fifth (5th) floor of the building commonly known as The Colonnade - Building One
located in Raleigh, North Carolina (the “Building”) (the “Premises”). 
  
 AND, WHEREAS, Tenant has requested Landlord’s consent to the Sublease attached hereto as Exhibit A (the “Sublease”), pursuant to which Subtenant shall sublease from Tenant, and Tenant shall sublease to
Subtenant, the Subleased Premises as defined in the Sublease. 
  
 NOW, THEREFORE, for good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereby agree as follows: 
  

1. Consent. Landlord does hereby consent to the Sublease, subject to the conditions contained herein. 
  
 2. Tenant Liability. Landlord’s consent herein is expressly
conditioned upon the payment of all rent and other charges, and the performance of all other obligations, in the Lease by the Tenant. This Consent shall in no way constitute a waiver or release of Tenant from its liabilities and responsibilities
under the Lease. Tenant hereby agrees that, notwithstanding the terms of the Sublease, Tenant shall remain principally liable and responsible for all liabilities and responsibilities of Tenant under the Lease. 
  
 3. Subtenant’s Obligations. Subtenant hereby acknowledges and
agrees to observe, comply with and perform all terms, conditions and covenants of the Lease, to perform all obligations of any kind whatsoever as and when the same are due to be performed by Tenant pursuant to the terms of the Lease, and to be
subject to all of the Landlord’s rights thereunder during the entire term of the Lease. To the extent anything contained in the Sublease is in conflict or inconsistent with the terms of the Lease, or appears to enhance or diminish the rights
and obligations of Landlord under the Lease, the terms of the Lease shall govern and control. To the extent anything contained in the Lease and/or Sublease is in conflict or inconsistent with the terms of this Consent, the terms of the Consent shall
govern and control. Notwithstanding anything to the contrary contained in the Sublease, Subtenant shall not act in any manner that is inconsistent with the terms of the Lease. 
  
 4. No Further Transfer or Renewal. This Consent shall not be deemed to be an authorization for or consent to any
further or other assignment, subletting or other agreement relating to the use or occupancy of the Premises and it shall not be deemed to allow a renewal 

  

 
under the Sublease without Landlord’s consent. Subtenant agrees that it will not assign or encumber, or permit to be encumbered, its rights or interests
under the Sublease, or sublet the whole or any part of the Subleased Premises, nor extend the term under the Sublease, without the prior written consent of Landlord, which consent may be granted or withheld in Landlord’s sole and absolute
discretion. 
  
 5. No Representations or Modifications.
Landlord joins in this Consent solely to grant its consent and, by doing so, Landlord does not thereby make any representations or warranties. Further, nothing contained in the Sublease or this Consent shall be construed as modifying, waiving or
affecting any of the provisions, covenants and conditions or any of the Landlord’s rights or remedies under the Lease other than as specifically set forth herein. 
  
 6. No Alterations. No alterations, additions, or physical changes shall be made in the Subleased Premises without
Landlord’s prior written consent in each instance, which shall be granted or withheld pursuant to the terms of the Lease. 
  
 7. Subtenant Default. Any breach or violation of any provisions of the Lease by Subtenant (whether by act or omission) shall be deemed to be and
shall constitute a default by Tenant in fulfilling such provision and, in such event, Landlord shall have all the rights, powers and remedies provided in the Lease or at law or in equity with respect to defaults. In the event of a default by
Subtenant under the Lease Landlord shall provide Tenant with notice of such default and after notice of such default Tenant shall have the opportunity, during the applicable time period established in the Lease, to cure such default. 
  
 8. Subtenant Holdover. Notwithstanding anything in this Consent or the
Sublease to the contrary, if Subtenant shall continue in possession of any portion of the Subleased Premises after the expiration or earlier termination of the term of the Lease, Tenant shall be primarily liable for any and all costs, expenses,
claims, damages and liabilities incurred by Landlord in connection therewith, and Landlord shall be entitled to pursue all rights and remedies granted to it under the Lease and the Sublease at law or equity. In addition, upon the occurrence of any
such holdover, Tenant shall vigorously pursue against Subtenant all rights and remedies available to it under the Sublease at law or in equity in order to remedy such holdover. 
  
 9. Right of First Offer. 
  

	 	(a)	So long as Tenant and Subtenant are both not in default under the Lease or the Sublease, Landlord will recognize Tenant’s Right of First Offer contained in Paragraph 6 of the
Special Provisions of the Lease subject to the provisions of this Section 9. 

  

	 	(b)	Rent for any Right of First Offer space shall be the then-current market rate for space in the Building. 

  

	 	(c)	In the event Tenant exercises a Right of First Offer granted under the Lease Landlord will not unreasonably withhold its consent to Tenant’s request to further sublease or
assign such space to Subtenant. In the event of an assignment, Tenant shall be released from any obligations under the Lease with respect to the Right of First Offer space. 

  

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 10. Notices. Any notices required or permitted hereunder shall be deemed to have been received
either (i) when delivered by hand, or (ii) on the first business day following the date delivered to Federal Express or another reputable over-night courier for next day delivery, addressed, if to Landlord or Tenant, to the addresses for notices
stated in the Lease, and if to Subtenant, to the address stated in the lease between Subtenant and Landlord for other space in the Building. Refusal to accept delivery of any notice shall be deemed receipt hereunder. 
  
 11. No Amendment. Notwithstanding anything to the contrary contained
in the Lease and/or the Sublease, Tenant and Subtenant shall not, without the prior written consent of Landlord in each instance, execute any amendment to or modification or extension of the Sublease, and any amendment or modification entered into
without such consent shall be void and of no force or effect. 
  
 12. No Modification. This Consent constitutes the entire agreement of the parties hereto with respect to the matters stated herein. This Consent may not be altered, amended, modified or changed orally, but only by an agreement in
writing signed by all of the parties hereto. 
  
 13. Consent
Fee. This Consent is conditioned upon Tenant’s payment to Landlord of the review fee in accordance with the Lease in the amount of One Thousand and No/100 Dollars ($1,000.00). 
  
 14. Captions. Captions are inserted for convenience only and shall not affect the construction hereof. 
  
 15. Counterparts. This Consent may be executed in counterparts, each
of which shall constitute an original and all of which together shall constitute one agreement. 
  
 16. Choice of Law. This Consent shall for all purposes be construed in accordance with and governed by the laws of North Carolina applicable to
agreements made and to be performed wholly therein. 
  
 17.
Brokers. Tenant and Subtenant agree to indemnify and hold Landlord harmless from and against any claims or causes of action for a commission or other form of compensation arising from the Sublease or the Lease. The provisions of this
Paragraph 17 shall survive the termination of the Lease and any renewal thereof. 
  
 [SIGNATURE PAGE FOLLOWS] 
  

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 IN WITNESS WHEREOF, the parties have caused this Consent to be duly executed on the date first above
written. 
  

															
	 LANDLORD:
	 	 	 	COLONNADE DEVELOPMENT LLC,
	 	 	 	 	 a Delaware limited liability company

					
	 	 	 	 	 	 	By:	 	G&I Colonnade LLC, a Delaware limited liability company, its managing member

															
						
	 	 	 	 	 	 	 	 	By:	 	G&I Investment Colonnade, LLC, a Delaware limited liability company, its managing member
							
	 	 	 	 	 	 	 	 	 	 	By:	 	G&I Investment Colonnade Corporation, a Delaware corporation, its managing member
								
	 	 	 	 	 	 	 	 	 	 	 	 	By: 	 	 Illegible

	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 Vice President

							
	 TENANT:
	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	SALIX PHARMACEUTICALS, INC.,
	 	 	 	 	 	 	 a California corporation

					
	 	 	 	 	 	 	By:	 	 /s/    Bradley D. Bainbridge

	 	 	 	 	 	 	 Name:
	 	 Bradley D. Bainbridge

	 	 	 	 	 	 	 Title:
	 	 VP, Commercial Ops

							
	 SUBTENANT:
	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	VOYAGER PHARMACEUTICAL CORP.,
	 	 	 	 	 	 	 a Delaware corporation

					
	 	 	 	 	 	 	By:	 	 /s/    David J. Corcoran

	 	 	 	 	 	 	 Name:
	 	 David J. Corcoran

	 	 	 	 	 	 	 Title:
	 	 Exec. VP

  

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 Attachments 
  
 Exhibit A -Sublease 
  

 -4- 

 STATE OF NORTH CAROLINA 
  
 SUBLEASE AGREEMENT 
  
 COUNTY OF WAKE 
  
 THIS AGREEMENT OF SUBLEASE (the “Sublease”) made as of this 30 day of April, 2005, by and between Salix Pharmaceuticals, Inc. a California
corporation (“Salix”)(hereinafter referred to as Sublessor) and Voyager Pharmaceuticals, Inc. a Delaware corporation having a principal place of business and mailing address of 8501 Colonnade Drive, Suite 500, Raleigh, NC 27615
(hereinafter referred to as Sublessee). 
  
 WITNESSETH: 

 
 WHEREAS, on June 30, 2000, Salix, as Lessee, entered into a Lease, as
amended and partially assigned by that Assignment and Assumption of First Amendment to Lease dated September 9, 2004 (which lease is hereinafter referred to as the “Master Lease”) with Colonnade Development, LLC as Lessor, having an office
at 150 Fayetteville Street Mall, Suite 1300, Raleigh, NC 27601, (hereinafter referred to as the “Master Lessor”), which lease concerns approximately 26,363 square feet of rentable space in the building known as Colonnade I, 8501 Colonnade
Drive, Raleigh, NC 27615 (the “Premises”); and, 
  
 WHEREAS, Sublessee desires to sublease the entire Premises from Sublessor, and Sublessor desires to sublease the Premises to Sublessee. 
  
 NOW, THEREFORE, in consideration of the rents and covenants hereinafter set forth to be paid and performed by Sublessee, Sublessor does hereby demise,
lease and let unto Sublessee, and the Sublessee does hereby lease and take from Sublessor upon the terms and conditions hereinafter set forth the following described Subleased Premises: 
  
 Approximately 26,363 square feet as shown on the sketch attached hereto as Exhibit A and incorporated herein by reference.

  
 1. RELATIONSHIP TO MASTER LEASE. The Sublease and all its
terms, covenants and provisions are and each of them is subject and subordinate to (i) the Master Lease (a copy of which is attached hereto as Exhibit B and made a part hereof by reference) under which Sublessor is in control of the Subleased
Premises; (ii) the rights as contained in the Master Lease of the owner or owners of the Premises and/or the land and building of which the Subleased Premises are a part; (iii) all rights of Master Lessor as contained in the Master Lease; and (iv)
to any and all mortgages or encumbrances now or hereafter affecting the Subleased Premises to which the Master Lease would be subordinated. Sublessee expressly agrees that, if Sublessor’s tenancy, control or right to possession shall terminate
by expiration or any other cause not due to the fault of Sublessor, this Sublease shall thereupon immediately cease and terminate and Sublessee shall give immediate possession to Sublessor; provided however, that the liability of the Sublessee to
the Sublessor or the liability of the Sublessor to the Sublessee for 

  

 
termination caused by the applicable party’s default under this Sublease shall not be discharged by reason of such termination. 
  
 2. PERFORMANCE OF MASTER LEASE TERMS. With respect to the Subleased Premises,
Sublessee shall receive all benefits which accrue to Sublessor under the Master Lease as it relates to the Subleased Premises. Sublessee hereby expressly, and without condition or reservation, agrees to assume the obligation for performance of all
Sublessor’s responsibilities under the Master Lease with respect to the Subleased Premises and, during the term hereof, to be subject to and bound by, and to faithfully and punctually perform and comply with all of the covenants, conditions,
stipulations, restrictions and agreements contained therein except as expressly excluded herein. Sublessee hereby agrees to indemnify and hold harmless Sublessor from and against any loss, claim, damage, expense or injury (including reasonable
attorney’s fees and court costs) which Sublessor may incur as a result of Sublessee’s failure to perform such obligations on behalf of Sublessor. Sublessor covenants and agrees that if and so long as the Sublessee shall pay the Base Rent
required of Sublessor to be paid under the Master Lease, and fully, faithfully and punctually observes the covenants and conditions hereof, Sublessee shall quietly enjoy the Subleased Premises, subject, however, to the terms of this Sublease and the
Master Lease. 
  
 3. TERM. The term of this Sublease shall
commence on the earlier of (i) the date Sublessee occupies the Subleased Premises or (ii) July 1, 2005 (“Commencement Date”) and expire on December 31, 2006. In addition, Sublessee shall have the option to renew the term of this Sublease,
at the then fair market value, for one (1) renewal term commencing on January 1, 2007 and expiring on March 31, 2011 by providing, no later than April 1, 2006, written notice to Sublessor of its intention to exercise the option. 
  
 4. RENT. During each month of the term of this Sublease, Sublessee covenants
to pay Sublessor as Base Rent the scheduled Base Rent due by Sublessor under Master Lease. 
  
 In addition to Base Rent, Sublessee shall pay its proportionate share of real estate taxes and operating expenses and any other charges passed through to Sublessor under the Master Lease (all, collectively,
“Additional Rent”) together with any other charges and payments required of Sublessee hereunder. Sublessee shall pay Sublessor the Base Rent and Additional Rent (collectively, “Rent”), without offset or deduction, prior notice or
demand, in advance on the first day of each calendar month of the term hereof. If the Commencement Date is a day other than the first day of a month, Rent for the month in which the Commencement Date occurs shall be prorated. Rent shall be paid to
Sublessor at 1700 Perimeter Park, Morrisville, NC 27560. Where permitted by applicable law, if any payment of Rent is not paid when due, Sublessee shall pay the Sublessor upon demand, as a late charge, an amount equal to five percent (5%) of each
Rent installment, or any part thereof, which is overdue for more than ten (10) days. 
  
 5. USE. Sublessee shall use the Subleased Premises for general office use only and at all times in compliance with the Master Lease. 
  
 6. CONDITION OF PREMISES. SUBLESSEE (i) ACCEPTS THE SUBLEASED PREMISES IN THEIR “AS IS” CONDITION ON THE
COMMENCEMENT DATE HEREOF, (ii) ACKNOWLEDGES THAT SUBLESSOR HAS MADE AND MAKES NO 

  

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REPRESENTATIONS OR WARRANTIES CONCERNING THE CONDITION OF THE SUBLEASED PREMISES OR THEIR FITNESS FOR THE USE INTENDED BY SUBLESSEE, AND (iii) AGREES THAT TO
THE MAXIMUM EXTENT PERMITTED BY LAW THE SUBLESSEE WAIVES ANY CLAIM IT HAS, MAY HAVE, OR OUGHT TO HAVE AGAINST THE SUBLESSOR, BASED ON OR ARISING OUT OF THE CONDITION OF THE SUBLEASED PREMISES. Sublessee shall, at all times during the term hereof,
keep and maintain the Subleased Premises in good condition and repair as required by the Master Lease, provided the Sublessee has no obligation to repair or restore the Subleased Premises to a better state of condition or repair than as of the
Commencement Date. Notwithstanding the foregoing, prior to Sublessee’s occupancy, Sublessor agrees to perform certain touch-up painting and to shampoo the carpets in the Subleased Premises for Sublessee. 
  
 7. INSURANCE AND INDEMNIFICATIONS. At all times during the term of this
Sublease, Sublessee shall, at Sublessee’s expense, keep in effect (i) a policy of Comprehensive General Liability insurance with a company and in amounts as required under the Master Lease, which policy shall name Sublessor and Master Lessor as
additional insureds; (ii) a policy of Workers’ Compensation insurance in at least the statutory amounts; and (iii) insurance covering loss to Sublessee’s personal property by fire or other casualty in accordance with the provisions of the
Master Lease. Sublessee shall indemnify, defend and hold harmless the Sublessor from and against any loss, claim, damage, expense or injury to persons or property caused by or arising out of (i) use and occupancy by Sublessee, its agents, employees,
contractors, licensees, or invitees, of the Subleased Premises; (ii) Sublessee’s default in the performance of its obligations hereunder or under the terms of the Master Lease; or (iii) any negligent or intentional act or omission by Sublessee,
its agents, employees, contractors, licensees or invitees. 
  
 8.
SURRENDER. At the expiration or earlier termination of this Sublease, Sublessee shall surrender the Subleased Premises to Sublessor in broom clean condition in the same condition as on the Commencement Date hereof, ordinary wear and tear excepted.
Sublessee warrants and covenants that it will pay the full cost of any repairs or maintenance necessary to restore the Subleased Premises to the same condition as on the Commencement Date hereof, ordinary wear and tear excepted. 
  
 9. ASSIGNMENT AND SUBLETTING. Sublessee may not assign this Sublease or
further sublet all or any part of the Subleased Premises without the prior written consent of Sublessor and Master Lessor, which consent, as from Sublessor, shall not be unreasonably withheld or delayed. A change in control of Sublessee shall be an
assignment hereunder. 
  
 10. DEFAULT. If Sublessee shall default
(i) in the payment of Rent as required hereunder, when and as due, or (ii) if Sublessee shall default in the performance of any of the other terms, covenants and conditions of this Sublease which remain uncured for fifteen (15) days after written
notice, or (iii) if any act or omission of Sublessee would be a default under the Master Lease were Sublessee the tenant thereunder, then Sublessor may (aa) avail itself of any remedy available to the Master Lessor under the Master Lease; (bb) avail
itself of any statutory remedy provided by the laws of the state in which the Subleased Premises are situated; (cc) re-enter, retake and repossess the Premises with or without notice or summary process; and/or (dd) terminate this Sublease.

  

 -3- 

 11. ACCESS. Sublessor shall be permitted access to the Subleased Premises at all reasonable times upon
reasonable advance notice, or at any time in case of emergency, to inspect the Subleased Premises or to show the Subleased Premises to other potential subtenants. Sublessor shall attempt to conduct all of its activities permitted under this
Paragraph in a manner which will not unreasonably inconvenience, annoy or disturb the Sublessee in its use and occupancy of the Subleased Premises. 
  
 12. NOTICE. Any notice required or permitted to be sent pursuant to this Sublease shall be sent by facsimile or certified mail, return receipt requested,
postage prepaid to the parties at the following addresses or facsimile numbers and to such other addresses or facsimile numbers as they shall from time to time indicate: 
  

			
	 Sublessee:
	 	 Sublessor:

		
	 Voyager Pharmaceuticals, Inc.
	 	 Salix Pharmaceuticals, Inc.

	 805 Colonnade Dr., Suite 501
	 	 1700 Perimeter Park Morrisville, NC 27560

	 Raleigh, NC 27615
	 	 Phone #: (919) 862-1000

	 Phone #: (919) 846-4880
	 	 Fax #: (919) 862-1095

	 Fax #: (919) 846-4881
	 	 Attn: Adam C. Derbyshire

	 Attn: Tim Creech
	 	 

  
 13. SUBLESSOR RELEASED
FROM LIABILITY IN CERTAIN EVENTS. Sublessor shall not be responsible to Sublessee, at any time or in any event, for deterioration or change in the condition of the Subleased Premises not caused by Sublessor’s gross negligence or willful
misconduct. Sublessor shall also not be responsible for any damage to Sublessee’s property contained therein, including injury to persons whether caused by riot or civil commotion, fire or earthquake damage, or overflow or leakage upon or into
the Subleased Premises, of water, steam, gas or electricity, or by any breakage in pipes or plumbing, or breakage, leakage or obstruction of sewer pipes or other damage occasioned by water being upon or coming through the roof, skylight, trapdoors,
walls, basement or otherwise, nor for failure of the heating (steam) plant, nor for loss of property by theft or otherwise, nor for any damage arising from any act or neglect of any co-tenant or other occupant of the Subleased Premises, or for that
of any owner or occupants of adjoining or contiguous property unless said damage, loss or injury results from the gross negligence or willful misconduct of Sublessor or its agents, employees or contractors. 
  
 14. CONSENT OF MASTER LESSOR; SUBLESSOR. This Sublease is subject to and
conditioned upon the consent of the Master Lessor. Sublessor will exercise the Right of First Offer under the Master Lease as and when Sublessee shall request it so long as Sublessor shall be released from any obligation under the Master Lease with
respect to such space. 
  
 15. ENTIRE AGREEMENT. This Sublease
(including the provisions of the Master Lease incorporated herein by reference) contains the entire agreement between the parties and any agreement hereafter made shall be ineffective to change, modify or discharge it in whole or in part unless such
agreement is in writing and signed by the parties hereto. 
  

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 16. SUBLESSEE’S REPRESENTATIONS AND WARRANTIES. Sublessee represents and warrants that (i) Sublessee
is a corporation existing and in good standing under the laws of the State of Delaware, and Sublessee is duly authorized to enter into this Sublease; (ii) the officer executing this Sublease on behalf of Sublessee is duly authorized to do so and to
bind the Sublessee hereto; and (iii) Sublessee shall provide Sublessor, upon request, with financial information on Sublessee and any guarantor of Sublessee’s obligation hereunder reasonably satisfactory to Sublessor. 
  
 17. MISCELLANEOUS. 
  
 a. If any term, covenant or condition of this Sublease or
the application thereof to any circumstances or to any person, corporation or other entity shall be invalid or unenforceable to any extent, the remaining terms, covenants and conditions of this Sublease shall not be affected thereby and shall be
valid and enforceable to the fullest extent permitted by law. 
  
 b. The paragraph headings contained in this Sublease have been included for convenience only and shall not be used in the construction or interpretation of this Sublease. 
  
 c. This Sublease shall be governed by and construed in
accordance with the laws of the State of North Carolina. 
  
 18.
ATTORNEYS’ FEES. In the event that any action or proceeding shall be brought by any party hereto against the other with respect to any matter arising under this Sublease, the prevailing party shall be entitled to recover from the other costs of
suit and reasonable attorney’s fees actually incurred. 
  
 19. SUCCESSORS AND ASSIGNS. This Sublease shall be binding upon and inure to the benefit of the parties hereto and their respective successors and permitted assigns. 
  
 20. HOLDOVER. Sublessee shall not be permitted to hold over after the expiration or earlier termination of the Master Lease,
and Sublessee shall indemnify Sublessor from and against any loss, cost or damage resulting therefrom. 
  
 21. BROKERAGE. Sublessee represents and warrants that it has dealt with no real estate broker other than Mike Morgan of Corporate Realty Advisors or agent
and Sublessor warrants that it has dealt with no real estate broker or agent other than John Stubbs and Austin Koon of Corporate Realty Advisors with respect to this transaction. Each party shall indemnify and hold harmless the other from and
against all claims of any other broker or agent claiming to have represented Sublessee or Sublessor as the case may be in this matter. Sublessor shall pay any fee or commission due the brokers so identified herein in accordance with the terms of a
separate agreement. 
  
 22. PERSONAL PROPERTY. Sublessor agrees to
leave in the Subleased Premises the following items of personal property at no charge to Sublessee: 
  
 a. (1) phone rack (4-19” pieces) 
  
 b. (1) APC computer rack 
  

 -5- 

 c. (1) refrigerator and all kitchen appliances in break room and conference room (not
including the plasma television or rented drink coolers) 
  
 d. (5) kitchen tables 
  
 e. (20) chairs for kitchen tables 
  
 f.
Numerous nameplates for offices 
  
 g. (5) swivel
cabinets located in the NDA room 
  
 In consideration of this
Sublease, Sublessee hereby grants and conveys title to such personal property to Sublessee “as is, where is,” with all faults and with no warranties. 
  

IN WITNESS WHEREOF, Sublessor and Sublessee have duly executed this Sublease effective as of the later date below on which the Sublease is executed by
both parties. 
  

									
	 SUBLESSOR:
	 	 	 	 SUBLESSEE:

			
	 Salix Pharmaceuticals, Inc.
	 	 	 	 Voyager Pharmaceuticals, Inc.

					
	By:	 	 /s/    Bradley D. Bainbridge
	 	 	 	 By:
	 	 /s/    David J. Corcoran

	 Name: 
	 	 Bradley D. Bainbridge
	 	 	 	 Name: 
	 	 David J. Corcoran

	 Title:
	 	 VP Commercial Ops
	 	 	 	 Title:
	 	 Exec VP

	 Date:
	 	 5/4/04
	 	 	 	 Date:
	 	 5-03-05

  

 -6- 

 By executing below, Master Lessor hereby agrees and consents to the terms of this Sublease. 
  

			
	MASTER LESSOR:
	
	 
		
	By:	 	 

			
		
	Name: 	 	 

			
		
	Title: 	 	 

			
		
	Date: 	 	 

  

 -7- 

 STATE OF New York 
  
 COUNTY OF New York 
  
 I, Susan Fottorusso, a Notary Public of said County and State, certify that David Luski personally came before me this day and acknowledged that he is VP
(title) of G&I Investment Colonnade Corporation, a Delaware corporation, the managing member of G&I Investment Colonnade, LLC, a Delaware limited liability company, the managing member of G&I Colonnade LLC, a Delaware limited liability
company, the managing member of Colonnade Development LLC, a Delaware limited liability company, the Landlord, and that he, as VP (title), being authorized to do so, executed the foregoing on behalf of the corporation. 
  
 Witness my hand and official seal, this the 2nd day of August, 2001.

  

	
	
	/s/    Susan Fottorusso
	 Notary Public

  
 My commission expires: 03/08/05

  
 (SEAL-STAMP) 
  
 STATE OF NC 
  
 COUNTY OF Wake 
  
 I, Michelle B. Simpson, a Notary Public of said County and State, certify that Robert Ruscher personally came before me this day and acknowledged that he is President (title) of Salix Pharmaceuticals, Inc., and that
he, as President (title), being authorized to do so, executed the foregoing on behalf of the corporation. 
  
 Witness my hand and official seal, this the 12th day of June, 2001. 
  

	
	
	/s/    Michelle B. Simpson
	 Notary Public

  
 My commission expires: 11-9-2002

  
 (SEAL-STAMP) 
  

 -8- 

  
 Yellow probate sheet is a vital part of your recorded document. 
  
 Please retain with original document and submit for rerecording. 
  

  
 Wake County Register of Deeds 
 Laura M. Riddick 
 Register of Deeds

  
 North Carolina-Wake County 
  

			
	The foregoing certificates of 	 	Michelle B. Simpson
	
	 
	
	 
	
	Susan Fottorusso
	
	 

  
 Notary(ies) Public is (are) certified
to be correct. This instrument and this certificate are duly registered at the date and time and in the book and page shown on the first page hereof. 
  

			
	Laura M. Riddick, Register of Deeds
		
	By:	 	/s/    Frederick C. Bayman
	 	 	Assistant/Deputy Register of Deeds

  

			
	 This Customer Group
  
     1     # of Time Stamps Needed
	 	 This Document
  
     5                     New Time
Stamp
  
                        # of Pages

  

 [Graphic of Tenant Profile]Lease Agreement, dated 10/4/04, between the Registrant and ARE-7030 Kit Creek

 Exhibit 10.8 
  
 LEASE AGREEMENT 
  
 THIS LEASE AGREEMENT (this “Lease”) is dated as of October 4, 2004, between ARE-7030 KIT CREEK, LLC, a Delaware limited liability
company (“Landlord”), and VOYAGER PHARMACEUTICAL, INC., a Delaware corporation (“Tenant”). 
  

			
		
	Building:	  	7020 Kit Creek Road, Research Triangle Park, North Carolina
		
	Premises:	  	That portion of the Building, containing approximately 3,109 rentable square feet, as determined by Landlord, as shown on Exhibit A.
		
	Project:	  	The real property on which the Building is located, together with all improvements thereon and appurtenances thereto as described on Exhibit B.
		
	Base Rent:	  	$8,031.58 per month, subject to adjustment as provided for in Section 3 below.
		
	Tenant’s Share:	  	6.64%
		
	Security Deposit:	  	$8,031.58
		
	Target Commencement Date:	  	December 1, 2004
		
	Rent Adjustment Percentage:	  	Greater of 3 or the CPI Adjustment Percentage not to exceed 5%
		
	Base Term:	  	Beginning on the Commencement Date (as hereinafter defined) and ending 36 months after the Rent Commencement Date (as hereinafter defined).
		
	Permitted Use:	  	Research and development laboratory, related office and other related uses consistent with the character of the Project and otherwise in compliance with the provisions of Section 6
hereof.

  

					
	 Address for Rent Payment:

	  	 Landlord’s Notice Address:

	  	 Tenant’s Notice Address:

	135 N. Los Robles Avenue
Suite 250
Pasadena, CA 91101
Attention: Accounts Receivable	  	135 N. Los Robles Avenue
Suite 250
Pasadena, CA 91101
Attention: Corporate Secretary
Facsimile: (612) 578-0770	  	8540 Colonnade Center Drive,
Suite 409
Raleigh, NC 27615
Attention: Michael Giannini
Facsimile:

  
 1. Lease of
Premises. Upon and subject to all of the terms and conditions hereof, Landlord hereby leases the Premises to Tenant and Tenant hereby leases the Premises from Landlord. The portions of the Project that are for the non-exclusive use of tenants of
the Project are collectively referred to herein as the “Common Areas.” Landlord reserves the right to modify Common Areas. 
  

 2. Delivery; Acceptance of Premises; Commencement Date. Landlord shall use reasonable efforts to
deliver the Premises to Tenant for the conduct of Tenant’s business on or before the Target Commencement Date (“Delivery” or “Deliver”). If Landlord fails to so Deliver the Premises, Landlord shall not be
liable to Tenant for any loss or damage resulting therefrom, and this Lease may be terminated by Landlord or Tenant by facsimile notice to the other within 30 days of the Target Commencement Date, and if so terminated by either: (a) the Security
Deposit, or any balance thereof (i.e., after deducting therefrom all amounts to which Landlord is entitled under the provisions of this Lease), shall be returned to Tenant, and (b) neither Landlord nor Tenant shall have any further rights,
duties or obligations under this Lease. The “Commencement Date” shall be the date Landlord Delivers the Premises to Tenant. The “Rent Commencement Date” shall be the date that is 4 months after the Commencement
Date. The “Term” of this Lease shall be the Base Term described on page 1 of this Lease and, if applicable, the Extension Term (as hereinafter defined) which Tenant may elect pursuant to Section 35 hereof. Upon request of
Landlord, Tenant shall execute and deliver a written acknowledgment of the Commencement Date and the expiration date of the Term when such are established in the form of the “Acknowledgement of Commencement Date” attached to this Lease as
Exhibit D; provided, however, Tenant’s failure to execute and deliver such acknowledgment shall not affect Landlord’s rights hereunder. 
  
 Except as expressly provided herein, effective as of the Commencement Date: (i) Tenant shall accept the Premises in their
condition as of such date, subject to all applicable Legal Requirements (as defined in Section 6 hereof); (ii) Landlord shall have no obligation for any defects in the Premises; and (iii) Tenant’s taking possession of the Premises shall
be conclusive evidence that Tenant accepts the Premises and that the Premises were in good condition at the time of Delivery. 
  
 Landlord shall construct improvements to the Premises which are described and shown on Exhibit E attached hereto (“Landlord’s
Work”). Landlord, at it sole cost and expense, shall be responsible for the compliance of the Premises as of the Commencement Date with the Americans With Disabilities Act, 42 U.S.C. § 12101, et seq. Other than Landlord’s Work,
Landlord shall not have any obligation whatsoever with respect to the finishing of the Premises for Tenant’s use and occupancy. 
  
 Tenant agrees and acknowledges that neither Landlord nor any agent of Landlord has made any representation or warranty with respect to the condition of
all or any portion of the Premises or the Project, and/or the suitability of the Premises or the Project for the conduct of Tenant’s business, and Tenant waives any implied warranty that the Premises or the Project are suitable for the
Permitted Use. This Lease constitutes the complete agreement of Landlord and Tenant with respect to the subject matter hereof and supersedes any and all prior representations, inducements, promises, agreements, understandings and negotiations which
are not contained herein. 
  
 3. Base Rent. 
  
 (a) Base Rent for the first month which Tenant is required to pay Base Rent
and the Security Deposit shall be due and payable on delivery of an executed copy of this Lease to Landlord. Commencing on the Rent Commencement Date, Tenant shall pay to Landlord in 

  

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advance, monthly installments of Base Rent on or before the first day of each calendar month during the Term hereof, in lawful money of the United States of
America, at the office of Landlord for payment of Rent set forth above. Payments of Base Rent for any fractional calendar month shall be prorated. Tenant shall have no right at any time to abate, reduce, or set-off any Rent due hereunder.

  
 (b) Base Rent shall be increased on each annual anniversary of
the Rent Commencement Date during the Term (each an “Adjustment Date”) by multiplying the Base Rent payable immediately before such Adjustment Date by the Rent Adjustment Percentage and adding the resulting amount to the Base Rent
payable immediately before such Adjustment Date. Base Rent, as so adjusted, shall thereafter be due as provided herein. Base Rent adjustments for any fractional calendar month shall be prorated. “CPI Adjustment Percentage” means (i)
a fraction, stated as a percentage, the numerator of which shall be the Index for the calendar month 3 months before the month in which the Adjustment Date occurs, and the denominator of which shall be the Index for the calendar month 3 months
before the last Adjustment Date or, if no prior Base Rent adjustment has been made, 3 months before the first day of the first full month during the Term of this Lease, less (ii) 1.00. “Index” means the “Consumer Price
Index-All Urban Consumers-MD, DC & VA Metropolitan Area, All Items” compiled by the U.S. Department of Labor, Bureau of Labor Statistics, (1982-84 = 100). If a substantial change is made in the Index, the revised Index shall be used,
subject to such adjustments as Landlord may reasonably deem appropriate in order to make the revised Index comparable to the prior Index. If the Bureau of Labor Statistics ceases to publish the Index, then the successor or most nearly comparable
index, as reasonably determined by Landlord, shall be used, subject to such adjustments as Landlord may reasonably deem appropriate in order to make the new index comparable to the Index. Landlord shall give Tenant written notice indicating the Base
Rent, as adjusted pursuant to this Section, and the method of computation and Tenant shall pay to Landlord an amount equal to any underpayment of Base Rent by Tenant within 15 days of Landlord’s notice to Tenant. Failure to deliver such notice
shall not reduce, abate, waive or diminish Tenant’s obligation to pay the adjusted Base Rent. 
  
 (c) In addition to Base Rent, commencing on the Commencement Date, Tenant agrees to pay to Landlord as additional rent (“Additional
Rent”): (i) Tenant’s Share of Operating Expenses (as defined in Section 4), and (ii) any and all other amounts Tenant assumes or agrees to pay under the provisions of this Lease, including, without limitation, any and all other
sums that may become due by reason of any default of Tenant or failure to comply with the agreements, terms, covenants and conditions of this Lease to be performed by Tenant, after any applicable notice and cure period. Tenant’s obligation to
pay Base Rent and Additional Rent hereunder are collectively referred to herein as “Rent”. 
  
 4. Operating Expense Payments. Landlord shall deliver to Tenant a written estimate of Operating Expenses for each calendar year during the Term
(the “Annual Estimate”), which may be revised by Landlord from time to time during such calendar year. Commencing on the Commencement Date, on the first day of each month during month of the Term, Tenant shall pay Landlord an amount
equal to 1/12th of Tenant’s Share of the Annual Estimate. Payments for any fractional calendar month shall be
prorated. 
  

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 The term “Operating Expenses” means all costs and expenses of any kind or description
whatsoever incurred or accrued each calendar year by Landlord with respect to the Building (including the Building’s share of all costs and expenses of any kind or description incurred or accrued by Landlord with respect to the Project which
are not specific to the Building or any other building located in the Project) (including, without duplication, taxes, reasonable reserves consistent with good business practice for future repairs and replacements, capital repairs and improvements
amortized over the lesser of 7 years and the useful life of such capital items, and the costs of Landlord’s third party property manager or, if there is no third party property manager, administration rent in the amount of 5.0% of Base Rent),
excluding only: 
  
 (a) the original construction costs of the
Project and renovation prior to the date of the Lease and costs of correcting defects in such original construction or renovation; 
  
 (b) capital expenditures for expansion of the Project; 
  
 (c) interest, principal payments of any mortgage covering the Project, debts of Landlord, financing costs and amortization of funds borrowed by Landlord,
whether secured or unsecured and all payments of base rent (but not taxes or operating expenses) under any ground lease or other underlying lease of all or any portion of the Project; 
  
 (d) depreciation of the Project (except for capital improvements, the cost of which are includable in Operating Expenses);

  
 (e) advertising, legal and space planning expenses and leasing
commissions and other costs and expenses incurred in procuring and leasing space to tenants for the Project, including any leasing office maintained in the Project, free rent and construction allowances for tenants; 
  
 (f) legal and other expenses incurred in the negotiation or enforcement of
leases; 
  
 (g) completing, fixturing, improving, renovating,
painting, redecorating or other work, which Landlord pays for or performs for other tenants within their premises, and costs of correcting defects in such work; 
  

(h) costs of utilities outside normal business hours sold to tenants of the Project; 
  
 (i) costs to be reimbursed by other tenants of the Project or taxes to be paid directly by Tenant or other tenants of the
Project, whether or not actually paid; 
  
 (j) salaries, wages,
benefits and other compensation paid to officers and employees of Landlord who are not assigned in whole or in part to the operation, management, maintenance or repair of the Project; 
  
 (k) general organizational, administrative and overhead costs relating to maintaining Landlord’s existence, either as a
corporation, partnership, or other entity, including general corporate, legal and accounting expenses; 
  
 (l) costs (including attorneys’ fees and costs of settlement, judgments and payments in lieu thereof) incurred in connection with disputes with
tenants, other occupants, or prospective 

  

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tenants, and costs and expenses, including legal fees, incurred in connection with negotiations or disputes with employees, consultants, management agents,
leasing agents, purchasers or mortgagees of the Building; 
  
 (m)
costs incurred by Landlord due to the violation by Landlord, its employees, agents or contractors or any tenant of the terms and conditions of any lease of space in the Project or any Legal Requirement (as defined in Section 6); 

 
 (n) penalties, fines or interest incurred as a result of Landlord’s
inability or failure to make payment of Taxes and/or to file any tax or informational returns when due, or from Landlord’s failure to make any payment of Taxes required to be made by Landlord hereunder before delinquency; 
  
 (o) overhead and profit increment paid to Landlord or to subsidiaries or
affiliates of Landlord for goods and/or services in or to the Project to the extent the same exceeds the costs of such goods and/or services rendered by unaffiliated third parties on a competitive basis; 
  
 (p) costs of Landlord’s charitable or political contributions, or of
fine art maintained at the Project; 
  
 (q) costs in connection
with services (including electricity), items or other benefits of a type which are not standard for the Project and which are not available to Tenant without specific charges therefor, but which are provided to another tenant or occupant of the
Project, whether or not such other tenant or occupant is specifically charged therefor by Landlord; 
  
 (r) costs incurred in the sale or refinancing of the Project; 
  
 (s) net income taxes of Landlord or the owner of any interest in the Project, franchise, capital stock, gift, estate or inheritance taxes or any federal,
state or local documentary taxes imposed against the Project or any portion thereof or interest therein; and 
  
 (t) any expenses otherwise includable within Operating Expenses to the extent actually reimbursed by persons other than tenants of the Project under
leases for space in the Project. 
  
 Within 90 days after the end
of each calendar year (or such longer period as may be reasonably required), Landlord shall furnish to Tenant a statement (an “Annual Statement”) showing in reasonable detail: (a) the total and Tenant’s Share of actual
Operating Expenses for the previous calendar year, and (b) the total of Tenant’s payments in respect of Operating Expenses for such year. If Tenant’s Share of actual Operating Expenses for such year exceeds Tenant’s payments of
Operating Expenses for such year, the excess shall be due and payable by Tenant as Rent within 30 days after delivery of such Annual Statement to Tenant. If Tenant’s payments of Operating Expenses for such year exceed Tenant’s Share of
actual Operating Expenses for such year Landlord shall pay the excess to Tenant within 30 days after delivery of such Annual Statement, except that after the expiration, or earlier termination of the Term or if Tenant is delinquent in its obligation
to pay Rent, Landlord shall pay the excess to Tenant after deducting all other amounts due Landlord. 
  

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 The Annual Statement shall be final and binding upon Tenant unless Tenant, within 30 days after
Tenant’s receipt thereof, shall contest any item therein by giving written notice to Landlord, specifying each item contested and the reason therefor. If, during such 30 day period, Tenant reasonably and in good faith questions or contests the
accuracy of Landlord’s statement of Tenant’s Share of Operating Expenses, Landlord will provide Tenant with access to Landlord’s books and records relating to the operation of the Project and such information as Landlord reasonably
determines to be responsive to Tenant’s questions (the “Expense Information”). If after Tenant’s review of such Expense Information, Landlord and Tenant cannot agree upon the amount of Tenant’s Share of Operating
Expenses, then Tenant shall have the right to have an independent public accounting firm selected by Tenant from among the 5 largest in the United States, working pursuant to a fee arrangement other than a contingent fee (at Tenant’s sole cost
and expense) and approved by Landlord (which approval shall not be unreasonably withheld or delayed), audit and/or review the Expense Information for the year in question (the “Independent Review”). The results of any such
Independent Review shall be binding on Landlord and Tenant. If the Independent Review shows that the payments actually made by Tenant with respect to Operating Expenses for the calendar year in question exceeded Tenant’s Share of Operating
Expenses for such calendar year, Landlord shall at Landlord’s option either (i) credit the excess amount to the next succeeding installments of estimated Operating Expenses or (ii) pay the excess to Tenant within 30 days after delivery of such
statement, except that after the expiration or earlier termination of this Lease or if Tenant is delinquent in its obligation to pay Rent, Landlord shall pay the excess to Tenant after deducting all other amounts due Landlord. If the Independent
Review shows that Tenant’s payments with respect to Operating Expenses for such calendar year were less than Tenant’s Share of Operating Expenses for the calendar year, Tenant shall pay the deficiency to Landlord within 30 days after
delivery of such statement. If the Independent Review shows that Tenant has overpaid with respect to Operating Expenses by more than 5% then Landlord shall reimburse Tenant for all costs incurred by Tenant for the Independent Review. Operating
Expenses for the calendar years in which Tenant’s obligation to share therein begins and ends shall be prorated. 
  
 5. Security Deposit. Tenant shall deposit with Landlord upon delivery of an executed copy of this Lease to Landlord and at all times during the
Term maintain security (the “Security Deposit”) for the performance of all of its obligations in the amount set forth in the Basic Lease Provisions, which security may, at Tenant’s option, be in the form of cash or a letter of
credit (the “Letter of Credit”) in form and substance and issued by an institution satisfactory to Landlord. Upon each occurrence of a Default (as defined in Section 16), Landlord may use all or any part of the Security
Deposit to pay delinquent payments due under this Lease, and the cost of any damage, injury, expense or liability caused by such Default, without prejudice to any other remedy provided herein or by law. Tenant hereby waives the provisions of any
law, now or hereafter in force, which provide that Landlord may claim from a security deposit only those sums reasonably necessary to remedy defaults in the payment of Rent, to repair damage caused by Tenant or to clean the Premises, it being agreed
that Landlord may, in addition, claim those sums reasonably necessary to compensate Landlord for any other loss or damage, foreseeable or unforeseeable, caused by the act or omission of Tenant or any officer, employee, agent or invitee of Tenant.

  
 6. Use. The Premises shall be used solely for
the Permitted Use set forth in the Basic Lease Provisions, in compliance with all laws, orders, judgments, ordinances, regulations, 

  

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codes, directives, permits, licenses, covenants and restrictions now or hereafter applicable to the Premises, and the use and occupancy thereof
(collectively, “Legal Requirements”). Tenant will use the Premises in a careful, safe and proper manner and will not commit waste, overload the floor or structure of the Premises, subject the Premises to use that would damage the
Premises or obstruct or interfere with the rights of Landlord or other tenants or occupants of the Project, including conducting or giving notice of any auction, liquidation, or going out of business sale on the Premises, or using or allowing the
Premises to be used for any unlawful purpose. 
  
 7. Holding
Over. If Tenant remains in possession of the Premises after the expiration or earlier termination of the Term without the express written consent of Landlord, (A) Tenant shall become a tenant at sufferance upon the terms of this Lease except
that the monthly rental shall be equal to 200% of the Rent in effect during the last 30 days of the Term, and (B) Tenant shall be responsible for all damages suffered by Landlord resulting from or occasioned by Tenant’s holding over, including
consequential damages. Acceptance by Landlord of Rent after the expiration of the Term or earlier termination of this Lease shall not result in a renewal or reinstatement of this Lease. 
  
 8. Parking. Tenant shall have the right to park in those areas designated for non-reserved parking in common with
other tenants of the Project pro rata in accordance with the rentable area of the Premises and the rentable areas of the Project, subject in each case to Landlord’s rules and regulations. Landlord shall not be responsible for enforcing
Tenant’s parking rights against any third parties, including other tenants of the Project. 
  
 9. Utilities, Services. Landlord shall provide, subject to reimbursement as part of Operating Expenses and the terms of this Section 9,
utilities to the Premises (“Utilities”). Tenant shall pay directly to the Utility provider, prior to delinquency, any separately metered Utilities and services which may be furnished to Tenant or the Premises during the Term. No
interruption or failure of Utilities, from any cause whatsoever other than Landlord’s willful misconduct, shall result in abatement of Rent. Tenant agrees to limit use of water and sewer with respect to Common Areas to normal restroom use.

  
 Landlord shall, subject to reimbursement as part of Operating
Expenses, make available for use at the Project by Tenant on a non-exclusive basis and solely for usage in the ordinary course of Tenant’s business operations at the Project: a T1 line and telephone system, a glass washer, autoclave, ice
machine, cage washer, cold room and a Kodak X-Omat 2000A (collectively, the “Equipment”). Tenant acknowledges and agrees that Tenant’s use of the foregoing items shall be subject to compliance with all Legal Requirements and
Landlord’s rules and regulations, as the same may be revised from time to time, including, without limitation, rules and regulations relating to shared use of the Equipment and that Landlord shall not be liable for any damages arising from any
act, omission or neglect of any tenant of the Project or any other third party. Landlord’s sole obligation for providing the Equipment shall be to contract with a third party to maintain the Equipment that is deemed by Landlord (in its sole and
absolute discretion) to need periodic maintenance per the manufacturer’s standard maintenance guidelines. Landlord shall have no obligation to provide Tenant with operational Equipment, back-up Equipment or back-up utilities or to supervise,
oversee or confirm that the third party maintaining the Equipment is maintaining the Equipment as per the manufacturer’s standard 

  

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guidelines or otherwise. During any period of replacement, repair or maintenance of the Equipment when such Equipment is not operational, including any
delays thereto due to the inability to obtain parts or replacements, Landlord shall have no obligation to provide Tenant with alternative or back-up Equipment. Tenant expressly acknowledges and agrees that Landlord does not guaranty that the
Equipment will be operational at all times, will function or perform adequately, and Landlord shall not be liable for any damages resulting from the failure of such Equipment. Tenant acknowledges that Landlord shall not be operating the Equipment
and that Tenant shall be responsible for all personnel required to operate the Equipment in connection with Tenant’s use thereof. Losses and damages caused by Tenant or any Tenant Party shall be repaired at Tenant’s sole cost and expense.
Tenant shall not undertake any repairs of the Equipment and Tenant waives any rights it may have under any state or local law to make any such repairs. 
  
 Landlord’s sole obligation for either providing emergency generators or providing emergency back-up power to Tenant shall be: (i) to provide
emergency generators with not less than the capacity of the emergency generators located in the Building as of the Commencement Date, and (ii) to contract with a third party to maintain the emergency generators as per the manufacturer’s
standard maintenance guidelines. Landlord shall have no obligation to provide Tenant with operational emergency generators or back-up power or to supervise, oversee or confirm that the third party maintaining the emergency generators is maintaining
the generators as per the manufacturer’s standard guidelines or otherwise. During any period of replacement, repair or maintenance of the emergency generators when the emergency generators are not operational, including any delays thereto due
to the inability to obtain parts or replacement equipment, Landlord shall have no obligation to provide Tenant with an alternative back-up generator or generators or alternative sources of back-up power. 
  
 10. Alterations. Tenant shall not make any alterations, additions, or
improvements to the Premises of any kind whatsoever. 
  
 11.
Landlord’s Repairs. Landlord, as an Operating Expense, shall maintain all of the Project and the Premises in good repair, reasonable wear and tear and uninsured losses and damages caused by Tenant, or by any of Tenant’s agents,
servants, employees, invitees and contractors (collectively, “Tenant Parties”) excluded. Landlord shall repair losses and damages caused by Tenant or any of Tenant Parties at Tenant’s sole cost and expense. Landlord reserves
the right to stop building system services when necessary. Landlord shall have no responsibility or liability for failure to supply building system services during any such period of interruption; provided, however, that Landlord shall
give Tenant 24 hours advance notice of any planned stoppage of building system services for routine maintenance, repairs, alterations or improvements. Landlord shall not be liable for any failure to make any repairs or to perform any maintenance
unless such failure shall persist for an unreasonable time after Tenant’s written notice of the need for such repairs or maintenance. 
  
 12. Liens. Tenant shall discharge, by bond or otherwise, any liens filed against the Premises or against the Project arising out of work performed
or claimed to have been performed, materials furnished or claimed to have been or obligations incurred or claimed to have been incurred by Tenant within 10 days after the filing thereof, at Tenant’s sole cost. 
  

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 13. Indemnification. Tenant hereby indemnifies and agrees to defend, save and hold Landlord
harmless from and against any and all claims for injury or death to persons or damage to property occurring within or about the Premises, arising directly or indirectly out of use or occupancy of the Premises, the use of the Equipment or a breach or
default by Tenant in the performance of any of its obligations hereunder, unless caused solely by the willful misconduct or gross negligence of Landlord. Landlord shall not be liable to Tenant for, and Tenant assumes all risk of damage to, personal
property (including, without limitation, loss of records kept within the Premises). Tenant further waives any and all claims for injury to Tenant’s business or loss of income relating to any such damage or destruction of personal property
(including, without limitation, any loss of records). Landlord shall not be liable for any damages arising from any act, omission or neglect of any tenant in the Project or of any other third party. 
  
 14. Insurance. Landlord shall, as an Operating Expense, maintain such
insurance covering the Project as Landlord shall determine. Tenant, at its sole cost and expense, shall maintain during the Term: workers’ compensation insurance with no less than the minimum limits required by law; employer’s liability
insurance with such limits as required by law; and commercial general liability insurance, with a minimum limit of not less than $2,000,000 per occurrence for bodily injury and property damage with respect to the Premises. The commercial general
liability insurance policies maintained by Tenant shall name Landlord, its officers, directors, employees, managers, agents, invitees and contractors (collectively, “Landlord Parties”), as additional insureds. The commercial general
liability insurance shall insure on an occurrence and not a claims-made basis; be issued by insurance companies which have a rating of not less than policyholder rating of A and financial category rating of at least Class X in “Best’s
Insurance Guide”; shall not be cancelable for nonpayment of premium unless 30 days prior written notice shall have been given to Landlord from the insurer; contain a hostile fire endorsement and a contractual liability endorsement; and provide
primary coverage to Landlord (any policy issued to Landlord providing duplicate or similar coverage shall be deemed excess over Tenant’s policies). Copies of such policies (if requested by Landlord), or certificates of insurance showing the
limits of coverage required hereunder and showing Landlord as an additional insured, along with reasonable evidence of the payment of premiums for the applicable period, shall be delivered to Landlord by Tenant upon commencement of the Term and with
respect to any renewal of insurance policy, no later than 5 days prior to the expiration of such policy. 
  
 15. Condemnation and Casualty. If at any time during the Term the Premises are in whole or in part (i) materially damaged or destroyed by a fire or
other casualty or (ii) taken for any public or quasi-public use under governmental law, ordinance, or regulation, or by right of eminent domain, or by private purchase in lieu thereof (a “Taking”), this Lease shall, at the written
election of Landlord or Tenant, terminate as of the date of such damage, destruction or Taking. Any statute or regulation which is now or may hereafter be in effect shall have no application to this Lease or any such damage, destruction or Taking,
the parties hereto expressly agreeing that this Section sets forth their entire understanding and agreement with respect to such matters. Upon any fire or other casualty or Taking, Landlord shall be entitled to receive the entire proceeds of the
insurance maintained by Landlord and the entire price or award from any such Taking without, in either case, any payment to Tenant, and Tenant hereby assigns to Landlord Tenant’s interest, if any, in such proceeds or award. 
  

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 16. Events of Default. Each of the following events shall be a default
(“Default”) by Tenant under this Lease: 
  
 (a)
Payment Defaults. Tenant shall fail to pay any installment of Rent or any other payment hereunder when due. 
  
 (b) Insurance. Any insurance required to be maintained by Tenant pursuant to this Lease shall be canceled or terminated or shall expire or shall be
reduced or materially changed, or Landlord shall receive a notice of nonrenewal of any such insurance and Tenant shall fail to obtain replacement insurance at least 20 days before the expiration of the current coverage. 
  
 (c) Other Defaults. Tenant shall fail to comply with any provision of
this Lease other than those specifically referred to in this Section 16, and, except as otherwise expressly provided herein, such failure shall continue for a period of 5 days after written notice thereof from Landlord to Tenant. 

 
 Any notice given under Section 16(c) hereof shall: (i) specify the alleged default,
(ii) demand that Tenant cure such default, (iii) be in lieu of, and not in addition to, or shall be deemed to be, any notice required under any provision of applicable law, and (iv) not be deemed a forfeiture or a termination of this Lease unless
Landlord elects otherwise in such notice. 
  
 17.
Landlord’s Remedies. 
  
 (a) Payment By Landlord;
Interest. Upon a Default by Tenant hereunder, Landlord may, without waiving or releasing any obligation of Tenant hereunder, make such payment or perform such act. All sums so paid or incurred by Landlord, together with interest thereon, from
the date such sums were paid or incurred, at the annual rate equal to 12% per annum or the highest rate permitted by law (the “Default Rate”), whichever is less, shall be payable to Landlord on demand as Additional Rent. Nothing
herein shall be construed to create or impose a duty on Landlord to mitigate any damages resulting from Tenant’s Default hereunder. 
  
 (b) Late Payment Rent. Late payment by Tenant to Landlord of Rent and other sums due will cause Landlord to incur costs not contemplated by this
Lease, the exact amount of which will be extremely difficult and impracticable to ascertain. Such costs include, but are not limited to, processing and accounting charges and late charges which may be imposed on Landlord under any Mortgage covering
the Premises. Therefore, if any installment of Rent due from Tenant is not received by Landlord within 5 days after the date such payment is due, Tenant shall pay to Landlord an additional sum equal to 6% of the overdue Rent as a late charge. The
parties agree that this late charge represents a fair and reasonable estimate of the costs Landlord will incur by reason of late payment by Tenant. In addition to the late charge, Rent not paid when due shall bear interest at the Default Rate from
the 5th day after the date due until paid. 
  
 (c) Other
Remedies. Upon the occurrence of a Default, Landlord, at its option, without further notice or demand to Tenant, shall have all rights and remedies provided at law or in equity. 
  

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 18. Assignment and Subletting. 
  
 (a) General Prohibition. Without Landlord’s prior written consent subject to and on the conditions described in
this Section 18, Tenant shall not, directly or indirectly, voluntarily or by operation of law, assign this Lease or sublease the Premises or any part thereof or mortgage, pledge, or hypothecate its leasehold interest or grant any concession
or license within the Premises, and any attempt to do any of the foregoing shall be void and of no effect. If Tenant is a corporation, partnership or limited liability company, the shares or other ownership interests thereof which are not actively
traded upon a stock exchange or in the over-the-counter market, a transfer or series of transfers whereby 25% or more of the issued and outstanding shares or other ownership interests of such corporation are, or voting control is, transferred (but
excepting transfers upon deaths of individual owners) from a person or persons or entity or entities which were owners thereof at time of execution of this Lease to persons or entities who were not owners of shares or other ownership interests of
the corporation, partnership or limited liability company at time of execution of this Lease, shall be deemed an assignment of this Lease requiring the consent of Landlord as provided in this Section 18. 
  
 (b) Permitted Transfers. If Tenant desires to assign, sublease,
hypothecate or otherwise transfer this Lease or sublet the Premises other than pursuant to a Permitted Assignment (as defined below), then at least 15 business days, but not more than 45 business days, before the date Tenant desires the assignment
or sublease to be effective (the “Assignment Date”), Tenant shall give Landlord a notice (the “Assignment Notice”) containing such information about the proposed assignee or sublessee, including the proposed use of
the Premises and any Hazardous Materials proposed to be used, stored handled, treated, generated in or released or disposed of from the Premises, the Assignment Date, any relationship between Tenant and the proposed assignee or sublessee, and all
material terms and conditions of the proposed assignment or sublease, including a copy of any proposed assignment or sublease in its final form, and such other information as Landlord may deem reasonably necessary or appropriate to its consideration
whether to grant its consent. Landlord may, by giving written notice to Tenant within 15 business days after receipt of the Assignment Notice: (i) grant such consent, (ii) refuse such consent, in its sole and absolute discretion, if the proposed
assignment, hypothecation or other transfer or subletting concerns more than (together with all other then effective subleases) 50% of the Premises, (iii) refuse such consent, in its reasonable discretion, if the proposed subletting concerns
(together with all other then effective subleases) 50% or less of the Premises (provided that Landlord shall further have the right to review and approve or disapprove the proposed form of sublease prior to the effective date of any such
subletting), or (iv) terminate this Lease with respect to the space described in the Assignment Notice as of the Assignment Date (an “Assignment Termination”). If Landlord delivers notice of its election to exercise an Assignment
Termination, Tenant shall have the right to withdraw such Assignment Notice by written notice to Landlord of such election within 5 business days after Landlord’s notice electing to exercise the Assignment Termination. If Tenant withdraws such
Assignment Notice, this Lease shall continue in full force and effect. If Tenant does not withdraw such Assignment Notice, this Lease, and the term and estate herein granted, shall terminate as of the Assignment Date with respect to the space
described in such Assignment Notice. No failure of Landlord to exercise any such option to terminate this Lease, or to deliver a timely notice in response to the Assignment Notice, shall be deemed to be Landlord’s consent to the proposed
assignment, sublease or other transfer. Tenant shall reimburse Landlord for all of Landlord’s reasonable out-of-pocket expenses in connection with its consideration of any Assignment Notice. 
  

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 Notwithstanding the foregoing, Landlord’s consent to an assignment of this Lease or a subletting of
any portion of the Premises to any entity controlling, controlled by or under common control with Tenant (a “Permitted Assignment”) shall not be required, provided that Landlord shall have the right to approve the form of any such
sublease or assignment. 
  
 (c) Additional Conditions. As a
condition to any such assignment or subletting, whether or not Landlord’s consent is required, Landlord may require: 
  
 (i) that any assignee or subtenant agree, in writing at the time of such assignment or subletting, that if Landlord gives such party
notice that Tenant is in default under this Lease, such party shall thereafter make all payments otherwise due Tenant directly to Landlord, which payments will be received by Landlord without any liability except to credit such payment against those
due under the Lease, and any such third party shall agree to attorn to Landlord or its successors and assigns should this Lease be terminated for any reason; provided, however, in no event shall Landlord or its successors or assigns be
obligated to accept such attornment; and 
  
 (ii)
A list of Hazardous Materials, certified by the proposed assignee or sublessee to be true and correct, which the proposed assignee or sublessee intends to use, store, handle, treat, generate in or release or dispose of from the Premises, together
with copies of all documents relating to such use, storage, handling, treatment, generation, release or disposal of Hazardous Materials by the proposed assignee or subtenant in the Premises or on the Project, prior to the proposed assignment or
subletting, including, without limitation: permits; approvals; reports and correspondence; storage and management plans; plans relating to the installation of any storage tanks to be installed in or under the Project (provided, said installation of
tanks shall only be permitted after Landlord has given its written consent to do so, which consent may be withheld in Landlord’s sole and absolute discretion); and all closure plans or any other documents required by any and all federal, state
and local Governmental Authorities for any storage tanks installed in, on or under the Project for the closure of any such tanks. Neither Tenant nor any such proposed assignee or subtenant is required, however, to provide Landlord with any
portion(s) of the such documents containing information of a proprietary nature which, in and of themselves, do not contain a reference to any Hazardous Materials or hazardous activities. 
  
 (d) No Release of Tenant, Sharing of Excess Rents. Notwithstanding any assignment or subletting, Tenant and any
guarantor or surety of Tenant’s obligations under this Lease shall at all times remain fully and primarily responsible and liable for the payment of Rent and for compliance with all of Tenant’s other obligations under this Lease. If the
Rent due and payable by a sublessee or assignee (or a combination of the rental payable under such sublease or assignment plus any bonus or other consideration therefor or incident thereto in any form) exceeds the sum of the rental payable under
this Lease, (excluding however, any Rent payable under this Section) and actual and reasonable brokerage fees, legal costs and any design or construction fees directly related to and required pursuant to the terms of any such sublease)
(“Excess Rent”), then Tenant shall be bound and obligated to pay Landlord as Additional Rent hereunder 50% of such Excess Rent within 10 days following receipt thereof by Tenant. If Tenant shall sublet the Premises or any part
thereof, Tenant hereby immediately and irrevocably 

  

 - 12 - 

 
assigns to Landlord, as security for Tenant’s obligations under this Lease, all rent from any such subletting, and Landlord as assignee and as
attorney-in-fact for Tenant, or a receiver for Tenant appointed on Landlord’s application, may collect such rent and apply it toward Tenant’s obligations under this Lease; except that, until the occurrence of a Default, Tenant shall have
the right to collect such rent. 
  
 (e) No Waiver. The
consent by Landlord to an assignment or subletting shall not relieve Tenant or any assignees of this Lease or any sublessees of the Premises from obtaining the consent of Landlord to any further assignment or subletting nor shall it release Tenant
or any assignee or sublessee of Tenant from full and primary liability under the Lease. The acceptance of Rent hereunder, or the acceptance of performance of any other term, covenant, or condition thereof, from any other person or entity shall not
be deemed to be a waiver of any of the provisions of this Lease or a consent to any subletting, assignment or other transfer of the Premises. 
  
 (f) Prior Conduct of Proposed Transferee. Notwithstanding any other provision of this Section 18, if (i) the proposed assignee or sublessee
of Tenant has been required by any prior landlord, lender or Governmental Authority to take remedial action in connection with Hazardous Materials contaminating a property, where the contamination resulted from such party’s action or use of the
property in question, (ii) the proposed assignee or sublessee is subject to an enforcement order issued by any Governmental Authority in connection with the use, storage, handling, treatment, generation, release or disposal of Hazardous Materials
(including, without limitation, any order related to the failure to make a required reporting to any Governmental Authority), or (iii) because of the existence of a pre-existing environmental condition in the vicinity of or underlying the Project,
the risk that Landlord would be targeted as a responsible party in connection with the remediation of such pre-existing environmental condition would be materially increased or exacerbated by the proposed use of Hazardous Materials by such proposed
assignee or sublessee, Landlord shall have the absolute right to refuse to consent to any assignment or subletting to any such party. 
  
 19. Estoppel Certificate. Tenant shall, within 10 business days of written notice from Landlord, execute, acknowledge and deliver an estoppel
certificate on any form reasonably requested by a proposed lender or purchaser. 
  
 20. Quiet Enjoyment. So long as Tenant shall perform all of the covenants and agreements herein required to be performed by Tenant, Tenant shall, subject to the terms of this Lease, at all times during the
Term, have peaceful and quiet enjoyment of the Premises against any person claiming by, through or under Landlord. 
  
 21. Prorations. All prorations required or permitted to be made hereunder shall be made on the basis of a 360 day year and 30 day months.

  
 22. Rules and Regulations. Tenant shall, at all times
during the Term and any extension thereof, comply with all reasonable rules and regulations at any time or from time to time established by Landlord covering use of the Premises and the Project. The current rules and regulations are attached hereto
as Exhibit C. If there is any conflict between said rules and regulations and other provisions of this Lease, the terms and provisions of this Lease shall 

  

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control. Landlord shall not have any liability or obligation for the breach of any rules or regulations by other tenants in the Project and shall not enforce
such rules and regulations in a discriminatory manner. 
  
 23.
Subordination. This Lease and Tenant’s interest and rights hereunder are and shall be subject and subordinate at all times to the lien of any Mortgage now existing or hereafter created on or against the Project or the Premises, and all
amendments, restatements, renewals, modifications, consolidations, refinancing, assignments and extensions thereof, without the necessity of any further instrument or act on the part of Tenant. Tenant agrees, at the election of the Holder of any
such Mortgage, to attorn to any such Holder. Tenant agrees upon demand to execute, acknowledge and deliver such instruments confirming such subordination and/or attornment as shall be requested by any such Holder. 
  
 24. Surrender. Upon the expiration of the Term or earlier termination
of Tenant’s right of possession, Tenant shall surrender the Premises to Landlord in the same condition as received, free of Hazardous Materials brought upon, kept, used, stored, handled, treated, generated in, or released or disposed of from,
the Premises by any person other than a Landlord Party (collectively, “Tenant HazMat Operations”) and released of all Hazardous Materials Clearances, broom clean, ordinary wear and tear and casualty loss and condemnation covered by
Section 15 excepted. At least 2 months prior to the surrender of the Premises, Tenant shall deliver to Landlord a narrative description of the actions proposed (or required by any governmental authority) to be taken by Tenant in order to
surrender the Premises at the expiration or earlier termination of the Term, free from any residual impact from the Tenant HazMat Operations and otherwise released for unrestricted use and occupancy (the “Surrender Plan”). Such
Surrender Plan shall be accompanied by a listing of (i) all Hazardous Materials licenses and permits held by or on behalf of any Tenant Party with respect to the Premises, and (ii) all Hazardous Materials used, stored, handled, treated, generated,
released or disposed of from the Premises, and shall be subject to the review and approval of Landlord’s environmental consultant. In connection with the review and approval of the Surrender Plan, upon the request of Landlord, Tenant shall
deliver to Landlord or its consultant such additional non-proprietary information concerning Tenant HazMat Operations as Landlord shall request. On or before such surrender, Tenant shall deliver to Landlord evidence that the approved Surrender Plan
shall have been satisfactorily completed and Landlord shall have the right, subject to reimbursement at Tenant’s expense as set forth below, to cause Landlord’s environmental consultant to inspect the Premises and perform such additional
procedures as may be deemed reasonably necessary to confirm that the Premises are, as of the effective date of such surrender or early termination of the Lease, free from any residual impact from Tenant HazMat Operations. Tenant shall reimburse
Landlord, as Additional Rent, for the actual out-of pocket expense incurred by Landlord for Landlord’s environmental consultant to review and approve the Surrender Plan and to visit the Premises and verify satisfactory completion of the same,
which cost shall not exceed $1,500. Landlord shall have the unrestricted right to deliver such Surrender Plan and any report by Landlord’s environmental consultant with respect to the surrender of the Premises to third parties. 
  
 If Tenant shall fail to prepare or submit a Surrender Plan approved by
Landlord, or if Tenant shall fail to complete the approved Surrender Plan, or if such Surrender Plan, whether or not approved by Landlord, shall fail to adequately address any residual effect of Tenant HazMat 

  

 - 14 - 

 
Operations in, on or about the Premises, Landlord shall have the right to take such actions as Landlord may deem reasonable or appropriate to assure that the
Premises and the Project are surrendered free from any residual impact from Tenant HazMat Operations, the cost of which actions shall be reimbursed by Tenant as Additional Rent, without regard to the limitation set forth in the first paragraph of
this Section 24. 
  
 Tenant shall immediately return to
Landlord all keys and/or access cards to parking, the Project, restrooms or all or any portion of the Premises furnished to or otherwise procured by Tenant. If any such access card or key is lost, Tenant shall pay to Landlord, at Landlord’s
election, either the cost of replacing such lost access card or key or the cost of reprogramming the access security system in which such access card was used or changing the lock or locks opened by such lost key. Any Tenant’s property not so
removed by Tenant as permitted or required herein shall be deemed abandoned and may be stored, removed, and disposed of by Landlord at Tenant’s expense, and Tenant waives all claims against Landlord for any damages resulting from
Landlord’s retention and/or disposition of such property. All obligations of Tenant hereunder not fully performed as of the termination of the Term, including the obligations of Tenant under Section 26 hereof, shall survive the
expiration or earlier termination of the Term, including, without limitation, indemnity obligations, payment obligations with respect to Rent and obligations concerning the condition and repair of the Premises. 
  
 25. Waiver of Jury Trial. TENANT AND LANDLORD WAIVE ANY RIGHT TO TRIAL
BY JURY OR TO HAVE A JURY PARTICIPATE IN RESOLVING ANY DISPUTE, WHETHER SOUNDING IN CONTRACT, TORT, OR OTHERWISE, BETWEEN LANDLORD AND TENANT ARISING OUT OF THIS LEASE OR ANY OTHER INSTRUMENT, DOCUMENT, OR AGREEMENT EXECUTED OR DELIVERED IN
CONNECTION HEREWITH OR THE TRANSACTIONS RELATED HERETO. 
  
 26.
Environmental Requirements. 
  
 (a)
Prohibition/Compliance/Indemnity. Tenant shall not cause or permit any Hazardous Materials (as hereinafter defined) to be brought upon, kept, used, stored, handled, treated, generated in or about, or released or disposed of from, the Premises
or the Project in violation of applicable Environmental Requirements (as hereinafter defined) by Tenant or any Tenant Party. If Tenant breaches the obligation stated in the preceding sentence, or if the presence of Hazardous Materials in the
Premises during the Term or any holding over results in contamination of the Premises, the Project or any adjacent property or if contamination of the Premises, the Project or any adjacent property by Hazardous Materials brought into, kept, used,
stored, handled, treated, generated in or about, or released or disposed of from, the Premises by anyone other than Landlord and Landlord’s employees, agents and contractors otherwise occurs during the Term or any holding over, Tenant hereby
indemnifies and shall defend and hold Landlord, its officers, directors, employees, agents and contractors harmless from any and all actions (including, without limitation, remedial or enforcement actions of any kind, administrative or judicial
proceedings, and orders or judgments arising out of or resulting therefrom), costs, claims, damages (including, without limitation, punitive damages and damages based upon diminution in value of the Premises or the Project, or the loss of, or
restriction on, use of the Premises or any portion of the Project), expenses (including, without limitation, attorneys’, consultants’ and experts’ fees, court costs and amounts paid in settlement of any 

  

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claims or actions), fines, forfeitures or other civil, administrative or criminal penalties, injunctive or other relief (whether or not based upon personal
injury, property damage, or contamination of, or adverse effects upon, the environment, water tables or natural resources), liabilities or losses (collectively, “Environmental Claims”) which arise during or after the Term as a
result of such contamination. This indemnification of Landlord by Tenant includes, without limitation, costs incurred in connection with any investigation of site conditions or any cleanup, treatment, remedial, removal, or restoration work required
by any federal, state or local governmental authority because of Hazardous Materials present in the air, soil or ground water above, on, or under the Premises. Without limiting the foregoing, if the presence of any Hazardous Materials on the
Premises, the Project or any adjacent property caused or permitted by Tenant or any Tenant Party results in any contamination of the Premises, the Project or any adjacent property, Tenant shall promptly take all actions at its sole expense and in
accordance with applicable Environmental Requirements as are necessary to return the Premises, the Project or any adjacent property to the condition existing prior to the time of such contamination, provided that Landlord’s approval of such
action shall first be obtained, which approval shall not unreasonably be withheld so long as such actions would not potentially have any material adverse long-term or short-term effect on the Premises or the Project. 
  
 (b) Business. As a material inducement to Landlord to allow Tenant to
use Hazardous Materials in connection with its business, Tenant agrees to deliver to Landlord prior to the Commencement Date a list identifying each type of Hazardous Materials to be brought upon, kept, used, stored, handled, treated, generated on,
or released or disposed of from, the Premises and setting forth any and all governmental approvals or permits required in connection with the presence, use, storage, handling, treatment, generation, release or disposal of such Hazardous Materials on
or from the Premises (“Hazardous Materials List”). Tenant shall deliver to Landlord true and correct copies of the following documents (the “Haz Mat Documents”) relating to the use, storage, handling, treatment,
generation, release or disposal of Hazardous Materials prior to the Commencement Date, or if unavailable at that time, concurrent with the receipt from or submission to a governmental authority: permits; approvals; reports and correspondence;
storage and management plans; and notices of violations of any Legal Requirements. 
  
 (c) Tenant’s Obligations. Tenant’s obligations under this Section 26 shall survive the expiration or earlier termination of the Lease. During any period of time after the expiration or earlier
termination of this Lease required by Tenant or Landlord to complete the removal from the Premises of any Hazardous Materials (including, without limitation, the release and termination of any licenses or permits restricting the use of the Premises
and the completion of the approved Surrender Plan), Tenant shall continue to pay the full Rent in accordance with this Lease for any portion of the Premises not relet by Landlord in Landlord’s sole discretion, which Rent shall be prorated
daily. 
  
 (d) Definitions. As used herein, the term
“Environmental Requirements” means all applicable present and future statutes, regulations, ordinances, rules, codes, judgments, orders or other similar enactments of any governmental authority regulating or relating to health,
safety, or environmental conditions on, under, or about the Premises or the Project, or the environment, including without limitation, the following: the Comprehensive Environmental Response, Compensation and Liability Act; the Resource Conservation
and Recovery Act; and all state and 

  

 - 16 - 

 
local counterparts thereto, and any regulations or policies promulgated or issued thereunder. As used herein, the term “Hazardous Materials”
means and includes any substance, material, waste, pollutant, or contaminant listed or defined as hazardous or toxic, or regulated by reason of its impact or potential impact on humans, animals and/or the environment under any Environmental
Requirements, asbestos and petroleum, including crude oil or any fraction thereof, natural gas liquids, liquefied natural gas, or synthetic gas usable for fuel (or mixtures of natural gas and such synthetic gas). As defined in Environmental
Requirements, Tenant is and shall be deemed to be the “operator” of Tenant’s “facility” and the “owner” of all Hazardous Materials brought on the Premises by Tenant or any Tenant Party, and the
wastes, by-products, or residues generated, resulting, or produced therefrom. 
  
 27. Tenant’s Remedies/Limitation of Liability. Landlord shall not be in default hereunder unless Landlord fails to perform any of its obligations hereunder within 30 days after written notice from Tenant
specifying such failure. TENANT’S SOLE REMEDY FOR ANY BREACH OR DEFAULT BY LANDLORD HEREUNDER SHALL BE TO TERMINATE THE LEASE AND TENANT HEREBY, TO THE MAXIMUM EXTENT POSSIBLE, KNOWINGLY WAIVES THE PROVISIONS OF ANY LAW, NOW OR HEREAFTER IN
FORCE WHICH PROVIDE ADDITIONAL OR OTHER REMEDIES TO TENANT AS A RESULT OF ANY BREACH BY LANDLORD HEREUNDER OR UNDER ANY SUCH LAW OR REGULATION. 
  
 28. Inspection and Access. Landlord and its agents, representatives, and contractors may enter the Premises at any reasonable time to inspect the
Premises and to make such repairs as may be required or permitted pursuant to this Lease, to perform such environmental tests as may be reasonably required to confirm Tenant’s compliance with the terms hereof and for any other business purpose.
Landlord and Landlord’s representatives may enter the Premises during business hours on not less than 48 hours advance written notice (except in the case of emergencies in which case no such notice shall be required and such entry may be at any
time) for the purpose of effecting any such repairs, inspecting the Premises, showing the Premises to prospective purchasers and, during the last year of the Term, to prospective tenants or for any other business purpose. 
  
 29. Security. Tenant acknowledges and agrees that security devices and
services, if any, while intended to deter crime may not in given instances prevent theft or other criminal acts and that Landlord is not providing any security services with respect to the Premises. Tenant agrees that Landlord shall not be liable to
Tenant for, and Tenant waives any claim against Landlord with respect to, any loss by theft or any other damage suffered or incurred by Tenant in connection with any unauthorized entry into the Premises or any other breach of security with respect
to the Premises. Tenant shall be solely responsible for the personal safety of Tenant’s officers, employees, agents, contractors, guests and invitees while any such person is in, on or about the Premises and/or the Project. Tenant shall at
Tenant’s cost obtain insurance coverage to the extent Tenant desires protection against such criminal acts. 
  
 30. Brokers, Entire Agreement, Amendment. Landlord and Tenant each represents and warrants that it has not dealt with any broker, agent or other
person (collectively, “Broker) in connection with this transaction and that no Broker brought about this transaction, other than Corporate Realty Advisors. Landlord and Tenant each hereby agree to indemnify and hold the 

  

 - 17 - 

 
other harmless from and against any claims by any Broker, other than the broker, if any named in this Section 30, claiming a commission or other form
of compensation by virtue of having dealt with Tenant or Landlord, as applicable, with regard to this leasing transaction. 
  
 31. Limitation on Landlord’s Liability. NOTWITHSTANDING ANYTHING SET FORTH HEREIN OR IN ANY OTHER AGREEMENT BETWEEN LANDLORD AND TENANT TO THE
CONTRARY: (A) LANDLORD SHALL NOT BE LIABLE TO TENANT OR ANY OTHER PERSON FOR (AND TENANT AND EACH SUCH OTHER PERSON ASSUME ALL RISK OF) LOSS, DAMAGE OR INJURY, WHETHER ACTUAL OR CONSEQUENTIAL TO: TENANT’S PERSONAL PROPERTY OF EVERY KIND AND
DESCRIPTION, INCLUDING, WITHOUT LIMITATION TRADE FIXTURES, EQUIPMENT, INVENTORY, SCIENTIFIC RESEARCH, SCIENTIFIC EXPERIMENTS, LABORATORY ANIMALS, PRODUCT, SPECIMENS, SAMPLES, AND/OR SCIENTIFIC, BUSINESS, ACCOUNTING AND OTHER RECORDS OF EVERY KIND
AND DESCRIPTION KEPT AT THE PREMISES AND ANY AND ALL INCOME DERIVED OR DERIVABLE THEREFROM; (B) THERE SHALL BE NO PERSONAL RECOURSE TO LANDLORD FOR ANY ACT OR OCCURRENCE IN, ON OR ABOUT THE PREMISES OR ARISING IN ANY WAY UNDER THIS LEASE OR ANY
OTHER AGREEMENT BETWEEN LANDLORD AND TENANT WITH RESPECT TO THE SUBJECT MATTER HEREOF AND ANY LIABILITY OF LANDLORD HEREUNDER SHALL BE STRICTLY LIMITED SOLELY TO LANDLORD’S INTEREST IN THE PROJECT OR ANY PROCEEDS FROM SALE OR CONDEMNATION
THEREOF AND ANY INSURANCE PROCEEDS PAYABLE IN RESPECT OF LANDLORD’S INTEREST IN THE PROJECT OR IN CONNECTION WITH ANY SUCH LOSS; AND (C) IN NO EVENT SHALL ANY PERSONAL LIABILITY BE ASSERTED AGAINST LANDLORD IN CONNECTION WITH THIS LEASE NOR
SHALL ANY RECOURSE BE HAD TO ANY OTHER PROPERTY OR ASSETS OF LANDLORD OR ANY OF LANDLORD’S OFFICERS, DIRECTORS, EMPLOYEES, AGENTS OR CONTRACTORS. UNDER NO CIRCUMSTANCES SHALL LANDLORD OR ANY OF LANDLORD’S OFFICERS, DIRECTORS, EMPLOYEES,
AGENTS OR CONTRACTORS BE LIABLE FOR INJURY TO TENANT’S BUSINESS OR FOR ANY LOSS OF INCOME OR PROFIT THEREFROM. 
  
 32. Severability. If any clause or provision of this Lease is illegal, invalid or unenforceable under present or future laws, then and in that
event, it is the intention of the parties hereto that the remainder of this Lease shall not be affected thereby. 
  
 33. Signs; Exterior Appearance. Tenant shall not: (i) attach anything at any time to any outside wall of the Project, (ii) use any window coverings
or sunscreen other than Landlord’s standard window coverings, (iii) place any articles on the window sills, (iv) place any items on any exterior balcony, or (v) paint, affix or exhibit any signs or any kind in the Premises which can be viewed
from the exterior of the Premises. Interior signs on doors and the directory tablet shall provided by Landlord at Tenant’s sole cost and expense. 
  
 34. Landlord’s Right to Relocate Tenant. Landlord shall have the right to relocate Tenant, upon 90 days’ prior written notice, from all
or part of the Premises to another area in the Project designated by Landlord (the “Relocation Premises”), provided that: (a) the size of the Relocation Premises is at least equal to the size of the Premises; and, (b) Landlord pays the

  

 - 18 - 

 
reasonable costs of moving Tenant and improving the Relocation Premises to a substantially similar standard as that of the Premises, and reimburses Tenant
for all reasonable costs directly incurred by Tenant as a result of relocation, including without limitation all costs incurred by Tenant replacing Tenant’s letterhead, promotional materials, business cards and similar items. Tenant shall
cooperate with Landlord in all reasonable ways to facilitate relocation. 
  
 35. Right to Extend Term. Tenant shall have the right to extend the Base Term of the Lease upon the following terms and conditions: 
  
 (a) Extension Right. Tenant shall have 1 right (the “Extension Right”) to extend the term of this
Lease for 3 years (the “Extension Term”) on the same terms and conditions as this Lease (other than Base Rent) by giving Landlord written notice of its election to exercise the Extension Right at least 3 months prior to the
expiration of the Base Term of the Lease. Base Rent shall be adjusted on the commencement date of the Extension Term by multiplying the Base Rent payable immediately before such date by 3% and adding the resulting amount to the Base Rent payable
immediately before such date. Thereafter, on each annual anniversary of the commencement date of the Extension Term, Base Rent shall be increased by multiplying the Base Rent payable immediately before such anniversary date by the Rent Adjustment
Percentage and adding the resulting amount to the Base Rent payable immediately before such anniversary date. 
  
 (b) Rights Personal. The Extension Right is personal to Tenant and is not assignable without Landlord’s consent, which may be granted or
withheld in Landlord’s sole discretion separate and apart from any consent by Landlord to an assignment of Tenant’s interest in the Lease. 
  
 (c) Exceptions. Notwithstanding anything set forth above to the contrary, the Extension Right shall not be in effect and Tenant may not
exercise the Extension Right: 
  
 (i) During any
period of time that Tenant is in Default under any provision of this Lease; or 
  
 (ii) if Tenant has been in Default under any provision of this Lease 3 or more times, whether or not the Defaults are cured, during the 12
month period immediately prior to the date that Tenant intends to exercise the Extension Right, whether or not the Defaults are cured. 
  
 (d) No Extensions. The period of time within which the Extension Right may be exercised shall not be extended or enlarged by reason of
Tenant’s inability to exercise the Extension Right. 
  
 (e)
Termination. The Extension Right shall terminate and be of no further force or effect even after Tenant’s due and timely exercise of the Extension Right, if, after such exercise, but prior to the commencement date of the Extension Term,
(i) Tenant fails to timely cure any default by Tenant under this Lease; or (ii) Tenant has Defaulted 3 or more times during the period from the date of the exercise of the Extension Right to the date of the commencement of the Extension Term,
whether or not such Defaults are cured. 
  

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 36. Right to Expand. 
  
 (a) Expansion in the Building. Tenant shall have the right, but not the obligation, to expand the Premises (the
“Expansion Right”) to include the Available Space in the Building upon the terms and conditions in this Section. For purposes of this Section 36(a), “Available Space” shall mean the entire Suite 110 and/or
the entire Suite 120 in the Building if the same is not occupied by a tenant or is occupied by an existing tenant whose lease is expiring within 6 months or less and such tenant does not wish to renew (whether or not such tenant has a right to
renew) its occupancy of such space. If there is Available Space in the Building, Landlord shall, at such time as Landlord shall elect so long as Tenant’s rights hereunder are preserved, deliver to Tenant written notice (the “Expansion
Notice”) of such Available Space, together with the terms and conditions on which Landlord is prepared to lease Tenant such Available Space. Tenant acknowledges that the Base Rent for the Available Space shall be the greater of the fair
market rental value of such space, as determined by Landlord, and the base rent per square foot which Tenant is then paying for the Premises. Tenant shall have 5 business days following delivery of the Expansion Notice to deliver to Landlord written
notification of Tenant’s exercise of the Expansion Right. Provided that no right to expand is exercised by any tenant with superior rights, Tenant shall be entitled to lease such Available Space upon the terms and conditions set forth in the
Expansion Notice. 
  
 (b) Amended Lease. If: (i) Tenant
fails to timely deliver notice accepting the terms of an Expansion Notice, or (ii) after the expiration of a period of 15 days from the date Tenant gives notice accepting Landlord’s offer to lease such Available Space, no lease amendment or
lease agreement for the Available Space has been executed, and Landlord tenders to Tenant an amendment to this Lease setting forth the terms for the rental of the Available Space consistent with those set forth in the Expansion Notice and otherwise
consistent with the terms of this Lease and Tenant fails to execute such Lease amendment within 5 business days following such tender, Tenant shall be deemed to have forever waived its right to lease the Available Space and Tenant shall have no
further rights under this Section 36. 
  
 (c)
Exceptions. Notwithstanding the above, the Expansion Right shall not be in effect and may not be exercised by Tenant: 
  
 (i) during any period of time that Tenant is in Default under any provision of the Lease; or 
  
 (ii) if Tenant has been in Default under any provision of
the Lease 3 or more times, whether or not the Defaults are cured, during the 12 month period prior to the date on which Tenant seeks to exercise the Expansion Right. 
  
 (d) Termination. The Expansion Right shall terminate and be of no further force or effect even after Tenant’s
due and timely exercise of the Expansion Right, if, after such exercise, but prior to the commencement date of the lease of such Available Space, (i) Tenant fails to timely cure any default by Tenant under the Lease; or (ii) Tenant has Defaulted 3
or more times during the period from the date of the exercise of the Expansion Right to the date of the commencement of the lease of the Available Space, whether or not such Defaults are cured. 
  

 - 20 - 

 (e) Rights Personal. Expansion Rights are personal to Tenant and are not assignable without
Landlord’s consent, which may be granted or withheld in Landlord’s sole discretion separate and apart from any consent by Landlord to an assignment of Tenant’s interest in the Lease. 
  
 37. Miscellaneous. 
  
 (a) Notices. Except as otherwise provided herein, all notices or other
communications between the parties shall be in writing and shall be deemed duly given upon delivery or refusal to accept delivery by the addressee thereof if delivered in person, confirmed receipt by facsimile or upon actual receipt if delivered by
reputable overnight guaranty courier, addressed and sent to the parties at their addresses set forth above. Landlord and Tenant may from time to time by written notice to the other designate another address for receipt of future notices. 

 

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 IN WITNESS WHEREOF, Landlord and Tenant have executed this Lease as of the day and year first above
written. 
  

			
	TENANT:
	
	VOYAGER PHARAMACEUTICAL, INC.,
a Delaware corporation
		
	By:	 	 /s/ David J. Corcoran

	 Its:
	 	 EVP

	
	LANDLORD:
	
	ARE-7030 KIT CREEK, LLC, a Delaware
limited liability company
		
	 By:
	 	ALEXANDRIA REAL ESTATE EQUITIES, L.P., a Delaware limited partnership, managing member

							
			
	 	 	By:	 	 ARE-QRS CORP.,
 a Maryland corporation, general partner

				
	 	 	 	 	 By:
	 	 /s/ Jennifer Pappas

	 	 	 	 	 Its:
	 	 JENNIFER PAPPAS
 V.P. & ASSISTANT SECRETARY

  

 - 22 - 

  
 EXHIBIT A 

DESCRIPTION OF PREMISES 
  
 [Graphic illustrating physical description] 
  

  
 EXHIBIT B 

Description of Project 
  
 Legal Description 
  
 Being a particular tract of land located in Wake County, Cedar Fork Township, Research Triangle Park, North Carolina and being further described below: 
  
 BEGINNING at an existing iron pipe, Baid iron pipe being located in the northerly
right-of-way of Kit Creek Road (NCSR 1639), and said iron pipe being the southeast property corner of Site 1     (Book of Maps 199_ Page 1391) and the southwest property corner of Parcel 17 (Book of Maps 1994 Page 674),
and said point bearing North Carolina Grid Coordinates NAD 83: North 233638.127 Meters, East 621,057,648 Meters, and said iron pipe being located a grid bearing of South 00” 07’ 36.89” East and a grid distance of 2,486.73 feet from
North Carolina Grid Monument “Ericsson”; 
  
 Thence, from the POINT OF
BEGINNING, leaving the right-of-way of Kit Creek Road, North 23o 42’ 26” East a distance of 404.80 feet to an existing iron pipe; Thence, North 58o 57’ 29” East a distance of 184.08 feet to an existing iron pipe;
Thence, North 50o 57’ 29” East a distance of 278.24 feet to a new iron pipe; Thence, North 80o 57’ 29” East a distance of 272.44 feet to an existing iron pipe set in the southerly right-of-way of Davis Drive (NCSR
1_13); Thence with the right-of-way of Davis Drive, South 50o 51’ 53” East a distance of 396.15 feet to an existing NODOT Rebar with Cap; Thence, South 40o 48’ 48” East a distance of 335.07 feet to an existing iron pipe
         at the interaction of the right-of-way of Davis Drive and the northerly right-of-way of Kit Creek Road; Thence with the right of way of Kit Creek Road, South 00o 26’ 36” East a
distance of 98.76 feet to a new iron pipe; Thence, South 48o 18’ 54” West a distance of 160.25 feet to a new iron pipe, the point of curvature of a tangent curve; Thence with a curve to the right having a radius of 937.71 feet, an arc
length of 1104.31 feet and being subtended by a chord bearing and distance of South 79o 88’ 10” West, 1041.69 feet to an existing rebar with cap; Thence, North 68o 18’ 23” West a distance of 217.66 feet to an existing
iron pipe the POINT AND PLACE OF BEGINNING and containing 784,027.78 Sq. Ft. (17.8888 Acres), and being shown on a particular survey or plot              “ALTA/ACSM Property
Survey – Parcel No. 17, Research Triangle Park” prepared by Barbara H. Mulkey Engineering, Inc., dated 08/08/2000 and revised 07/12/2000. 
  

  
 EXHIBIT C TO LEASE

  
 Rules and Regulations 
  
 1. The sidewalk, entries, and driveways of the Project shall not be
obstructed by Tenant, or any Tenant Party, or used by them for any purpose other than ingress and egress to and from the Premises. 
  
 2. Tenant shall not place any objects, including antennas, outdoor furniture, etc., in the parking areas, landscaped areas or other areas outside of its
Premises, or on the roof of the Project. 
  
 3. Except for animals
assisting the disabled, no animals shall be allowed in the offices, halls, or corridors in the Project. 
  
 4. Tenant shall not disturb the occupants of the Project or adjoining buildings by the use of any radio or musical instrument or by the making of loud or
improper noises. 
  
 5. If Tenant desires telegraphic, telephonic
or other electric connections in the Premises, Landlord or its agent will direct the electrician as to where and how the wires may be introduced; and, without such direction, no boring or cutting of wires will be permitted. Any such installation or
connection shall be made at Tenant’s expense. 
  
 6. Tenant
shall not install or operate any steam or gas engine or boiler, or other mechanical apparatus in the Premises, except as specifically approved in the Lease. The use of oil, gas or inflammable liquids for heating, lighting or any other purpose is
expressly prohibited. Explosives or other articles deemed extra hazardous shall not be brought into the Project. 
  
 7. Parking any type of recreational vehicles is specifically prohibited on or about the Project. Except for the overnight parking of operative vehicles,
no vehicle of any type shall be stored in the parking areas at any time. In the event that a vehicle is disabled, it shall be removed within 48 hours. There shall be no “For Sale” or other advertising signs on or about any parked vehicle.
All vehicles shall be parked in the designated parking areas in conformity with all signs and other markings. All parking will be open parking, and no reserved parking, numbering or lettering of individual spaces will be permitted except as
specified by Landlord. 
  
 8. Tenant shall maintain the Premises
free from rodents, insects and other pests. 
  
 9. Landlord
reserves the right to exclude or expel from the Project any person who, in the judgment of Landlord, is intoxicated or under the influence of liquor or drugs or who shall in any manner do any act in violation of the Rules and Regulations of the
Project. 
  
 10. Tenant shall not cause any unnecessary labor by
reason of Tenant’s carelessness or indifference in the preservation of good order and cleanliness. Landlord shall not be responsible to Tenant for any loss of property on the Premises, however occurring, or for any damage done to the effects of
Tenant by the janitors or any other employee or person. 
  

 11. Tenant shall give Landlord prompt notice of any defects in the water, lawn sprinkler, sewage, gas
pipes, electrical lights and fixtures, heating apparatus, or any other service equipment affecting the Premises. 
  
 12. Tenant shall not permit storage outside the Premises, including without limitation, outside storage of trucks and other vehicles, or dumping of waste
or refuse or permit any harmful materials to be placed in any drainage system or sanitary system in or about the Premises. 
  
 13. All moveable trash receptacles provided by the trash disposal firm for the Premises must be kept in the trash enclosure areas, if any, provided for
that purpose. 
  
 14. No auction, public or private, will be
permitted on the Premises or the Project. 
  
 15. No awnings shall
be placed over the windows in the Premises except with the prior written consent of Landlord. 
  
 16. The Premises shall not be used for lodging, sleeping or cooking or for any immoral or illegal purposes or for any purpose other than that specified in the Lease. No gaming devices shall be operated in the
Premises. 
  
 17. Tenant shall ascertain from Landlord the maximum
amount of electrical current which can safely be used in the Premises, taking into account the capacity of the electrical wiring in the Project and the Premises and the needs of other tenants, and shall not use more than such safe capacity.
Landlord’s consent to the installation of electric equipment shall not relieve Tenant from the obligation not to use more electricity than such safe capacity. 
  
 18. Tenant assumes full responsibility for protecting the Premises from theft, robbery and pilferage. 
  
 19. Tenant shall not install or operate on the Premises any machinery or
mechanical devices of a nature not directly related to Tenant’s ordinary use of the Premises and shall keep all such machinery free of vibration, noise and air waves which may be transmitted beyond the Premises. 
  

 - 2 - 

  
 EXHIBIT D TO LEASE

  
 ACKNOWLEDGMENT OF COMMENCEMENT DATE

  
 This ACKNOWLEDGMENT OF COMMENCEMENT DATE is
made this      day of                 ,
                    , between ARE-7030 KIT CREEK, LLC, a Delaware limited liability company (“Landlord”), and
VOYAGER PHARMACEUTICAL, INC., a                  corporation, and is attached to and made a part of the Lease dated October
    , 2004 (the “Lease”), by and between Landlord and Tenant. Any initially capitalized terms used but not defined herein shall have the meanings given them in the Lease. 
  
 Landlord and Tenant hereby acknowledge and agree, for all purposes of the
Lease, that the Commencement Date of the Base Term of the Lease is                    ,
                    , the Rent Commencement Date is April 1, 2005, and the termination date of the Base Term of the Lease shall be midnight
on,                             . 
  
 IN WITNESS WHEREOF, Landlord and Tenant have executed this ACKNOWLEDGMENT OF COMMENCEMENT DATE to be effective on the date
first above written. 
  

			
	TENANT:
	
	VOYAGER PHARAMACEUTICAL, INC.,
a ___________ corporation
		
	By:	 	 
	 Its:
	 	 
	
	LANDLORD:
	
	ARE-7030 KIT CREEK, LLC, a Delaware
limited liability company
		
	 By:
	 	ALEXANDRIA REAL ESTATE EQUITIES, L.P., a Delaware limited partnership, managing member

							
			
	 	 	By:	 	 ARE-QRS CORP.,
 a Maryland corporation, general partner

				
	 	 	 	 	 By:
	 	 
	 	 	 	 	 Its:
	 	 

  

  
 EXHIBIT E 

Landlord’s Work 
  
 Landlord will, at its sole cost and expense, install within the Premises the following improvements as listed and depicted on the plan below: 
  

	 	1.	One additional casework island to match the existing island in the main laboratory area. 

  

	 	2.	Two 3-prong 208V outlets on the emergency power system for Tenant provided freezers. 

  

	 	3.	Five 4-foot mobile benches. 

  

	 	4.	Two private offices and 3 cubicle areas constructed using Landlord’s standard demountable wall system—landlord will provided convenience outlets and tel/data to each
office and cubicle. The office layout to be mutually agreed upon by Landlord and Tenant. 

  

	 	5.	Landlord will install carpet in tile floor area adjacent to the office space. 

  

	 	6.	One exhaust connection for Tenant’s animal cage system. 

  

	 	7.	One outlet on the emergency power system for Tenant provided animal caging system. 

  

	 	8.	One standard 120V outlet in the main lab. 

  

	 	9.	Install 2 doors in existing cased openings into the specialty lab. 

  
 INSERT GRAPH 
  

 FIRST AMENDMENT TO LEASE AGREEMENT 
  
 THIS FIRST AMENDMENT TO LEASE AGREEMENT (this “First Amendment”) is made as of July 11, 2005, by and
between ARE-7030 KIT CREEK, LLC, a Delaware limited liability company (“Landlord”), and VOYAGER PHARMACEUTICAL CORPORATION, a Delaware corporation (“Tenant”). 
  
 RECITALS 
  
 A. Landlord and Tenant are parties to that certain Lease Agreement dated as of October 4, 2004 (the
“Lease”), pursuant to which Tenant leases certain space containing approximately 3,109 rentable square feet in a building located at 7020 Kit Creek Road, Research Triangle Park, North Carolina. Capitalized terms used herein without
definition shall have the meanings defined for such terms in the Lease. 
  
 B. Landlord and Tenant desire to amend the Lease to, among other things, expand the Premises, in accordance with Section 36 of the Lease, to include that portion of the Building known as Suite 120 and containing approximately
1,214 additional rentable square feet (the “First Expansion Space”), subject to the terms and conditions set forth below. 
  
 NOW, THEREFORE, in consideration of the foregoing Recitals, which are incorporated herein by this reference, the mutual promises and conditions
contained herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant hereby agree as follows: 
  

	1.	Definition of Premises. Effective upon the full execution and delivery of this First Amendment (the “Effective Date”), the definition of
Premises on Page 1 of the Lease is hereby deleted in its entirety and replaced with the following: 

  

			
	“Premises:	  	That portion of the Building containing approximately 4,323 rentable square feet, as determined by Landlord, as shown on Exhibit A.”

  
 Exhibit A
attached to the Lease is also hereby deleted in its entirety and replaced with the revised Exhibit A attached to this First Amendment. 
  

	2.	Base Rent. 

  
 (a) The definition of “Base Rent” on Page 1 of the Lease is hereby deleted in its entirety and replaced with the following: 
  
 “Base Rent: $31.00 per rentable square foot per
year, payable in equal monthly installments and subject to adjustment as provided for in Section 3 below” 
  

 (b) Notwithstanding anything to the contrary contained in the Lease, Tenant shall not be required to pay
Base Rent for the First Expansion Space for the first 5 months following the Effective Date. 
  

	3.	Tenant’s Share. Commencing on the Effective Date, the definition of “Tenant’s Share” is hereby deleted in its entirety and replaced with the
following: 

  
 “Tenant’s Share:
9.29% 
  

	4.	Landlord’s Work. Landlord shall construct the improvements to the First Expansion Space shown on Exhibit B attached to this First Amendment
(“Landlord’s First Expansion Space Work”). Once Landlord’s First Expansion Space Work is commenced, Landlord shall diligently and continuously prosecute the same to completion. Tenant shall not interfere with the
construction of Landlord’s First Expansion Space Work nor with any inspections or the issuance of any approvals by any applicable governmental authority. Tenant acknowledges and agrees that Landlord shall have no liability to Tenant in
connections with the construction of Landlord’s First Expansion Space Work and that Tenant shall not be entitled to any rental abatement or offset in connection therewith. Other than Landlord’s First Expansion Space Work, Landlord shall
not have any obligation whatsoever with respect to the finishing of the First Expansion Space for Tenant’s use and occupancy. Tenant shall accept the First Expansion Space in its “as is” condition and without any representations and
warranties from Landlord. 

  

	5.	Miscellaneous. 

  
 a. This First Amendment is the entire agreement between the parties with respect to the subject matter hereof and supersedes all prior and
contemporaneous oral and written agreements and discussions. This First Amendment may be amended only by an agreement in writing, signed by the parties hereto. 
  

b. This First Amendment is binding upon and shall inure to the benefit of the parties hereto, their respective agents, employees,
representatives, officers, directors, divisions, subsidiaries, affiliates, assigns, heirs, successors in interest and shareholders. 
  
 c. This First Amendment may be executed in any number of counterparts, each of which shall be deemed an original, but all of which when taken
together shall constitute one and the same instrument. The signature page of any counterpart may be detached therefrom without impairing the legal effect of the signature(s) thereon provided such signature page is attached to any other counterpart
identical thereto except having additional signature pages executed by other parties to this First Amendment attached thereto, 
  
 d. Except as amended and/or modified by this First Amendment, the Lease is hereby ratified and confirmed and all other terms of the Lease shall
remain in full force and effect, unaltered and unchanged by this First Amendment. In the event of any conflict between the provisions of this First Amendment and the provisions of the Lease, the provisions of this First Amendment shall prevail.
Whether or not specifically amended 

  

 - 2- 

 
by this First Amendment, all of the terms and provisions of the Lease are hereby amended to the extent necessary to give effect to the purpose and intent of
this First Amendment. 
  
 [Signatures are on the next page.]

  

 - 3 - 

  
 IN WITNESS WHEREOF,
the parties hereto have executed this First Amendment as of the day and year first above written. 
  

													
	LANDLORD:	 	 	 	 	 	ARE-7030 KIT CREEK, LLC, a Delaware limited liability company
					
	 	 	 	 	 	 	By:	 	ALEXANDRIA REAL ESTATE EQUITIES, L.P., a Delaware limited partnership, managing member
						
	 	 	 	 	 	 	 	 	By:	 	ARE-QRS CORP.,
	 	 	 	 	 	 	 	 	 	 	a Maryland corporation, general partner
							
	 	 	 	 	 	 	 	 	 	 	By:	 	/s/    Jennifer Pappas
	 	 	 	 	 	 	 	 	 	 	 Its:
	 	V.P. & Assistant Secretary

  

									
	TENANT:	 	 	 	VOYAGER PHARMACEUTICAL CORPORATION,
a Delaware corporation
					
	 	 	 	 	 	 	By:	 	/s/    David J. Corcoran
	 	 	 	 	 	 	 Its:
	 	EVP
	 	 	 	 	 	 	 	 	7/1/05

  

 S-1 

  
 EXHIBIT A 

DESCRIPTION OF PREMISES 
  
 [Graphic illustrating physical description] 
  

  
 EXHIBIT B 

Landlord’s Work 
  
 Landlord will, at its sole cost and expense, install within the Premises the following improvements as listed and depicted on the plan below: 
  

	 	1.	Furnish and install a door to the specialty lab with a passage door handle and sidelight. 

  

	 	2.	Furnish and install a door from suite 120 lab to suite 130 lab with a passage door handle and sidelight. Door to swing into suite 120. 

  

	 	3.	Furnish and install eight 4-foot sections of Fisher Scientific mobile casework to be located by the tenant during install. Mobile bench configurations to be as follows:

  

	 	a.	Two 4-door/I-drawer bench with upper shelving 

  

	 	b.	Two 4-door/1-drawer bench no upper shelving 

  

	 	c.	Three 4-drawer with knee spacer bench no upper shelving 

  

	 	d.	One 1-doorr with knee spacer bench no upper shelving 

  

	 	4.	Furnish and install wire mold under windows to match configuration in suite 130 lab under the windows 

  

	 	5.	Furnish and install on vac line and one electrical outlet to be connected to a tenant supplied laminar flow hood 

  

	 	6.	Furnish and install emergency power outlet for incubator 

  

	 	7.	Furnish and install one duplex 120 V outlet 

  

	 	8.	Furnish and install emergency power outlet for tenant’s 4C fridge 

  

	 	9.	Furnish and install emergency power outlet for tenant’s -80 freezer 

  

	 	10.	Furnish and install emergency power outlet for tenant’s -20 freezer 

  

	 	11.	Furnish and install one duplex 120 V outlet 

  
 [Graphic illustrating physical description]

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