Document:

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                                                                    EXHIBIT 10.9

                              CONSULTING AGREEMENT
                     INNOVEX INC. AND THE MEDICINES COMPANY
                                 (PROJECT #8138)

     This Consulting Agreement ("Agreement"), dated December 1, 1998 is by and
between Innovex Inc. ("Innovex"), whose principal office is at Waterview
Corporate Center, 10 Waterview Boulevard, Parsippany, New Jersey 07054, and The
Medicines Company ("The Medicines Company"), whose principal office is located
at One Cambridge Center, Cambridge, Massachusetts 02142.

     In consideration of the following covenants, promises and obligations, The
Medicines Company and Innovex agree as follows:

1.   SERVICES

     In accordance with the terms and conditions of this Agreement, The
Medicines Company retains Innovex for the purpose of providing consulting,
marketing and sales services set forth in Schedule A attached to this Agreement
(the "Services").

2.   AUTHORIZATION FOR PROCUREMENT SERVICES

     The Medicines Company shall be the beneficiary of all services performed by
outside service providers and all agreements for such services shall be subject
to the authorization requirements set forth in Schedule B to this Agreement.

3.   COMPENSATION AND EXPENSES

     The Medicines Company shall pay Innovex for services performed at the
following rates:

Director of Marketing        $ 150.00 Per Hour

Product Manager              $ 100.00 Per Hour

     All expenses billed by outside service providers shall be passed through to
The Medicines Company. Innovex shall receive a three percent (3%) administrative
fee for all expenses passed through to The Medicines Company.

     The Medicines Company will reimburse Innovex for reasonable out of pocket
costs and expenses that are necessary and actually incurred by Innovex pursuant
to the implementation of this Agreement. Request for reimbursement of expenses
and costs will be submitted at the end of each month. Each invoice shall be
supported by appropriate documentation of expenses. Notwithstanding the
foregoing, Innovex shall not incur total costs and expenses in excess of $5,000
per month without the prior written approval of the Medicines Company.

     All invoices are strictly net of any taxes, and payment in full must be
made within thirty (30) days of the date of the invoice, after which time
interest shall be due and payable on all unpaid balances at the rate of 1.5% per
month.

     Payment by check should be mailed to the following address:

         Innovex lnc.
         Waterview Corporate Center
         10 Waterview Boulevard
         Parsippany, New Jersey 07054

     Innovex's Federal Employment ID Number is 06-1076709.

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4.   TERM & TERMINATION

     The period of performance of this Agreement will begin on December 1, 1998,
and will continue until terminated by the parties, in the manner provided by
this Agreement.

     A party may terminate this Agreement if the other party is in material
breach of the Agreement and has not cured the breach within fifteen (15) days of
written notice specifying the breach. Consent to extend the cure period shall
not be unreasonably withheld, so long as the breaching party has commenced cure
during the fifteen (15) day notice period and pursues cure of the breach in good
faith.

     Either party may terminate this Agreement without cause with thirty days
written notice. Upon termination without cause by The Medicines Company, The
Medicines Company will pay Innovex all fees earned as of the date of
termination, all reasonable costs and expenses incurred prior to termination,
and all reasonable documented non-cancelable costs and expenses.

     Termination of this Agreement for whatever reason shall not affect the
accrued rights of either Innovex, or The Medicines Company arising under or out
of this Agreement and all provisions which expressly or by the implication
survive this Agreement shall remain in full force and effect.

5.   RELATIONSHIP OF THE PARTIES.

     Innovex is an independent contractor and shall have no authority to act as
an agent of The Medicines Company or to create or assume any binding obligation
in The Medicines Company's name, except as expressly provided herein. Each party
will be solely responsible for payment of all compensation owed to its employees
as well as employment related taxes, worker's compensation, and general
liability insurance.

     Under no circumstances shall Innovex be liable to an outside service
provider for any direct or indirect, special or consequential damages caused by
the fault or negligence of The Medicines Company, its employees or agents and
Innovex shall under no circumstances be a guarantor of commitments made by The
Medicines Company.

6.   CONFIDENTIAL INFORMATION.

     Innovex and The Medicines Company agree that all information whether or not
in writing relating to the research, products, business affairs or finances of
the other, or of any suppliers, agents, distributors, licensees or customers of
the other which comes into possession of Innovex or The Medicines Company under
this Agreement shall be Confidential Information ("Confidential Information").
The Confidential Information shall be marked as confidential or otherwise
represented by the disclosing party as confidential either before or within a
reasonable time of the disclosure. Innovex and The Medicines Company agree to
hold Confidential Information in strict confidence, use such Confidential
Information only for the purposes of performing their respective obligations
under the Agreement and disclose it only on a need-to-know basis to
subcontractors and employees who are under a written obligation to maintain the
confidentiality of the information. By way of illustration, but not limitation.
Confidential Information may include inventions, products, processes, methods,
techniques, formulas, compositions,

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compounds, projects, developments, plans, research data, clinical data,
financial data, personnel data, computer programs, customer and supplier lists
and contacts at or knowledge of customers or prospective customers of the
Medicines Company.

     The obligations of the parties in this Section 6 shall not extend to any
Confidential Information: (i) which can be shown by written documentation to
have been known by the recipient prior to its receipt from the other; (ii) which
is generally known to the public at the time of the disclosure or becomes
generally known through no wrongful act on the part of the receiving party;
(iii) becomes known to the receiving party through disclosure by sources other
than the disclosing party having the legal right to disclose such Confidential
Information; (iv) which by mutual written agreement is released from a
confidential status; or (v) which is required to be disclosed under any
statutory, regulatory or judicial requirement, and in that event,
confidentiality will be preserved and protected to the extent possible;
additionally, notice will be provided to the other party prior to any such
disclosure.

     The obligations of Innovex and The Medicines Company under this Section 6
shall survive the termination or expiration of this Agreement for a period of
five (5) years.

7.   LIABILITY

     The liability of Innovex for any loss or damage suffered by The Medicines
Company as a result of any breach of the Agreement or of any other liability of
Innovex in connection with the performance of the Services shall be limited to
an amount which shall not exceed the total amount of any payments made to the
Innovex under this Agreement by The Medicines Company to the date the liability
arose.

     Innovex shall not be liable for the following losses or damages howsoever
incurred (even if foreseeable or in the contemplation of Innovex or The
Medicines Company): (i) loss of profits, business or revenue, whether suffered
by The Medicines Company or any other person; or (ii) special, indirect, or
consequential loss, whether suffered by The Medicines Company or any other
person.

     The Medicines Company agrees to defend, indemnify and hold Innovex harmless
from and against any and all claims, damages, costs, expenses or other
liabilities, including reasonable attorneys fees, arising out of the use or
publication of any data or work product generated or produced by Innovex as a
result of this Agreement, or as a result of any breach by The Medicines Company
of any of the terms ~f this Agreement, provided this indemnity shall not extend
to any claim, demand or legal action arising as a result of any breach of this
Agreement by Innovex or resulting form the gross negligence or intentional
misconduct of Innovex.

8.   DOCUMENTS AND RECORDS

     Upon the written request of The Medicines Company, Innovex will destroy or
return at the expense of The Medicines Company all materials belonging to The
Medicines Company.

9.   ASSIGNMENT

     Neither party may assign this Agreement without the prior written consent
of the other party.

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10.  NOTICES

     All notices under this Agreement shall be in writing and shall be deemed
duly given (i) when received if personally delivered or sent by facsimile
transmission, or (ii) three (3) business days (Saturdays, Sundays, Bank and
public holidays excluded) after the date mailed, if sent by registered or
certified mail return receipt requested and postage prepaid, and addressed to
the parties at the following addresses:

If to The Medicines Company to:

         Clive Meanwell, CEO
         One Cambridge Center
         Cambridge, MA 02142
         Phone: (617) 225-9099
         Fax: (617) 225-2397 -

If to Innovex to:

         David Stack, President
         Waterview Corporate Center
         10 Waterview Boulevard
         Parsippany, NJ 07054
         Phone: (973) 257-4570
         Fax: (973) 257-4581

or to such other destination as either party may hereafter notify the other
party in accordance with this section.

11.  REPRESENTATIONS & WARRANTIES

     Each party warrants and represents to the other that it has the full right
and authority to enter into this Agreement, and that it is not aware of any
impediment that would inhibit its ability to perform its obligations under this
Agreement.

     Innovex and The Medicines Company agree to undertake all of their
respective obligations under this Agreement in conformance with generally
accepted business standards, and in material conformance with all applicable
local, state and federal laws and regulations.

12.  NON-EXCLUSIVE ARRANGEMENT

     This Agreement is not to be interpreted as an exclusive consulting
agreement. Nothing stated herein shall prevent Innovex or any affiliate of the
Innovex from accepting other assignments during the term of this Agreement.
Notwithstanding the foregoing, it is specifically understood and agreed that
Innovex and affiliates of the Innovex, from time to time, may enter into
consulting and other agreements with competitors of The Medicines Company
without incurring any liability for breach of this Agreement.

13.  GENERAL PROVISIONS

     This Agreement shall be governed by and construed in accordance with the
laws of the State of New Jersey, without giving effect to the principles of
conflict laws.

     Neither party's waiver of the other's breach of any term, covenant or
condition contained in this Agreement shall be deemed to be a waiver of any
subsequent breach of the same or any other term, covenant or condition in this
Agreement.

     If any part or parts of this Agreement are held to be invalid, the
remaining parts of the Agreement will continue to be valid and enforceable.

     The covenants contained in this Agreement which by their terms, require
their performance after the expiration or termination of this Agreement shall be

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enforceable notwithstanding the expiration or termination of this Agreement.

     This Agreement, and the materials incorporated herein by reference,
constitute the entire agreement of the parties and supersedes all prior
contracts, agreements and understandings relating to the same subject matter
between the parties. The parties intend this Agreement to be a complete
statement of the terms of their agreement, and no change or modification of any
of the provisions of this Agreement shall be effective unless it is in writing
and signed by a duly authorized representative of the party against which it is
to be enforced.

     This Agreement may be executed in several counterparts, each of which shall
be deemed an original but all of which shall constitute one and the same
instrument.

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     IN WITNESS WHEREOF, the parties have executed this Agreement as of the date
first above written.

INNOVEX INC.                         THE MEDICINES COMPANY

By: /s/ Dave Stack                   By: /s/ Richard Malcolm
   -------------------------------      ---------------------------------------
Name: Dave Stack                     Name:  Richard Malcolm
Title: President                     Title:  Chief Operating Officer

February 17, 1999

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                                   SCHEDULE A

                                   SERVICES

A.   MARKETING AND STRATEGIC SERVICES

     Innovex shall develop and implement marketing and sales strategies for The
Medicines Company. Such marketing and strategic services will include, but are
not limited to, assisting The Medicines Company in developing and implementing
marketing and sales strategies for Hirulog pursuant to The Medicines Company's
Business Plan (the "Business Plan"); participating as a member of marketing
teams established by The Medicines Company pursuant to the Business Plan;
coordinating communication with service providers in implementing marketing and
sales strategies; and other marketing and strategic services as mutually agreed
from time to time.

B.   PROCUREMENT SERVICES

     Innovex shall identify service providers to execute marketing and sales
strategies on behalf of The Medicines Company. Innovex shall, upon authorization
from The Medicines Company as set forth in Schedule B, have the authority on
behalf of The Medicines Company to procure and negotiate agreements with service
providers for all reasonable or necessary outside services in connection with
implementing the marketing and sales strategies. Innovex shall monitor and
manage the performance of such service providers under these agreements.

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                                   SCHEDULE B

                     AUTHORIZATION FOR PROCUREMENT SERVICES

     Prior to entering into any agreements with service providers or entering
into any legal commitments on behalf of The Medicines Company, Innovex shall (A)
comply with provisions (i) and (ii) below and with any written policy of The
Medicines Company concerning the procurement of bids or proposals and (B) make a
good faith determination that The Medicines Company has not elected to provide
or procure such goods or services itself.

     (i) Prior to agreeing to any specific purchase of goods or services which
exceed $1,000, Innovex shall obtain bids from one or more suppliers and
recommend to The Medicines Company the supplier from which the procurement of
goods or services would be most appropriate. The Medicines Company shall then
notify Innovex as to which supplier to use.

     (ii) Innovex shall maintain and on request, in a timely and reasonable
manner, provide The Medicines Company with complete documentation for all
procurement of goods and services. Innovex will negotiate terms of a written
agreement with the service providers, including, without limitation, provisions
addressing the specific duties and standards for performance, deliverables,
payment schedule, confidentiality, ownership of intellectual property, insurance
and indemnification. Innovex will engage legal counsel, as needed, to draft
service provider agreements. The final terms of such written agreements shall be
subject to the consent of the Medicines Company, such consent shall not be
unreasonably withheld.

     (iii) The Medicines Company shall be responsible for executing written
agreements with service providers and for payment of all fees in connection with
agreements with service providers.<PAGE>   1

                                                                   EXHIBIT 10.10

                               ALLIANCE AGREEMENT

         This Alliance Agreement (this "Agreement") is made and entered into as
of the ____ day of August 1996, by and between Medicines Development Company, a
Delaware corporation (the "Company"), and PharmaBio Development Inc., a North
Carolina corporation and a wholly owned subsidiary of Quintiles Transnational
Corp. ("PharmaBio").

         WHEREAS, the Company, PharmaBio, Warburg, Pincus, Ventures L.P., MPM
Medicines L.P., Hanseatic Americas LDC, Clive Meanwell, Scott Johnson, and
Ansbert Gadicke are parties to a stock purchase agreement dated as of the even
date herewith (the "Purchase Agreement"); and

         WHEREAS, a condition to closing pursuant to Section 4.5 of the Purchase
Agreement is the execution and delivery of this Agreement by the Company and
PharmaBio;

         NOW, THEREFORE, in consideration of the terms and conditions herein
contained and contained in the Purchase Agreement, the Company and PharmaBio
agree as follows:

1.0      SCOPE OF SERVICES
         -----------------

         1.1 SERVICES RELATING TO COMPANY'S DEVELOPMENT PROGRAMS

         As reasonably requested by the Company from time to time, PharmaBio
shall provide services to the Company to review and evaluate, jointly with the
Company, development programs created by the Company relating to potential or
actual product acquisitions. Such services shall be provided at no charge to the
Company by PharmaBio. The parties acknowledge that the purpose of this
collaboration is to optimize the duration, cost, specifications and quality
aspects of each of the Company's product development programs, and that the
parties anticipate that this collaborative planning process will lead to
substantial improvements in product development and performance compared with
the performance considered normal for the biopharmaceutical industry. The
parties further acknowledge that plans relating to product development involve a
dynamic process, and that such plans may require modification from time to time
in order to achieve optimal duration, cost and quality performances. The parties
agree to endeavor to create a collaborative relationship in which planning and
product development can be pursued effectively and efficiently. Unless otherwise
agreed by the Company, PharmaBio shall provide such services reasonably
requested by the Company, subject to Section 1.5.

         1.2 PROJECT SERVICES

         With respect to each of the Company's products, the Company shall
consult with PharmaBio regarding all services which the Company desires to
outsource relating to such products. All such services within the scope of
PharmaBio's (and its affiliates') then customary services shall be offered to
PharmaBio and PharmaBio shall agree to perform

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such services reasonably requested by the Company, subject to Section 1.5.
Services provided by PharmaBio shall include, but not be limited to, clinical
development services, non-clinical development services, project management
services, expert consultation regarding project implementation, pharmaeconomic
services, regulatory affairs services, post-marketing clinical, regulatory and
pharmacosurveillance services, and statistical, statistical programming, data
processing, data management, and clerical services.

         1.3 SERVICE AGREEMENTS

         All services provided by PharmaBio to the Company shall be subject to
the terms and conditions of this Agreement. Additionally, as a condition to
acceptance of project services pursuant to Section 1.2 hereof, the Company and
PharmaBio shall enter into a project services agreement, which shall be
substantially in the form of PharmaBio's then standard form of services
agreement and in any event which shall contain provisions covering scope of
work, project specifications, quality standards, and fees and costs (consistent
with Section 2.0 hereof). All material services agreements shall be reviewed by
Dennis Gillings or Rachel Selisker.

         1.4 PERFORMANCE OF SERVICES

         In performing services referred to in Section 1.2, PharmaBio agrees to
assure that these services are conducted in substantial compliance with, when
appropriate, any applicable protocol and specifications and with all applicable
laws, rules and regulations of the subject jurisdictions. PharmaBio also agrees
to cause the services it is to perform pursuant to Section 1.0 hereof to be
rendered by one or more of its affiliates which also are direct or indirect
subsidiaries of Quintiles Transnational Corp. The Company acknowledges and
agrees that such services will be performed by affiliates of PharmaBio.

         1.5 LIMITATION OF SERVICES

         PharmaBio shall not be required to perform any services which, as
determined by PharmaBio in good faith, either: (i) are beyond PharmaBio's
customary scope of services; (ii) compromise PharmaBio's conflict of interest,
professional or ethical policies; or (iii) are beyond PharmaBio's reasonable
capacity. In the event that PharmaBio determines that it will decline to provide
the proposed services due to a conflict of interest relating thereto, PharmaBio
shall notify the Company as soon as practicable of any such conflict of
interest. As to any services declined by PharmaBio, at the Company's request
PharmaBio shall use its best efforts in locating and evaluating, jointly with
the Company, an alternative provider for the contemplated services. PharmaBio
may assist the Company in planning and managing projects performed by
alternative service providers.

                                      -2-
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2.0      FEES FOR SERVICES
         -----------------

         2.1 AMOUNT OF FEES

         The Company shall pay to PharmaBio its then standard fees for services
rendered pursuant to Section 1.0 hereof. PharmaBio shall provide the Company a
schedule of such standard fees from time to time upon request of the Company.
The parties agree that the standard fees of PharmaBio shall be the fees which
PharmaBio normally charges for the types of services proposed to be provided to
multinational pharmaceutical companies at the time such services are provided,
PharmaBio agrees to consult with the Company regarding PharmaBio's fees for each
project and to establish such fees in good faith, taking into consideration
constraints imposed by short duration development time and international
standards of quality. From time to time, upon request by the Company, PharmaBio
shall provide information to the Company which reasonably establishes that the
fees paid by Company to PharmaBio are Quintiles' then standard fees; provided,
however, that PharmaBio shall not be required to provide any information to the
Company which PharmaBio believes in good faith will compromise any
confidentiality arrangements between PharmaBio and its other clients. The
Company will pay PharmaBio on a use basis at cost for network/mainframe computer
time, online disk storage and for printing and supplies.

         2.2 BONUS

             2.2.1 BONUS FOR EXCEPTIONAL PERFORMANCE

         At the time the parties enter into the service agreement with respect
to any project, the parties shall use their best efforts to agree in writing to
certain performance standards for such project (the "Bonus Standards") which
must be achieved by PharmaBio in order for it to be entitled to a payment in
excess of the fees provided by Section 2.1 (the "Bonus Fee") and to agree to the
overall fees and costs of the project under Section 2.0 (the "Planned Cost").
The parties acknowledge that a Bonus Standard shall be based on exceptional,
industry leading performance and such other levels of performance as may be
agreed to by the parties. The parties anticipate that the Bonus Fee shall be up
to ten percent (10%) of "net revenue" PharmaBio receives for a project under
this Section 2.0. "Net revenue" shall be determined in the same manner as it is
determined by Quintiles. Transnational Corp. for purposes of its audited
financial statements. Should the parties be unable to agree to the establishment
of the Bonus Standard, the Bonus Fee and the Planned Cost or as to whether
PharmaBio is entitled to the Bonus Fee, the dispute resolution procedures set
forth in Section 3.0 shall be followed. During the course of any project, the
parties may mutually agree in writing to modify the Bonus Standard, Bonus Fee or
Planned Cost.

             2.2.2 PAYMENT OF BONUS FEE

         If PharmaBio shall achieve any Bonus Standard for a project and the
actual fees and costs of such project shall be equal to or less than the Planned
Cost plus any fees and costs arising out of any change orders for such project,
PharmaBio shall be entitled to the

                                      -3-
<PAGE>   4

Bonus Fee for such project, which shall be paid promptly by the Company upon
achievement of such Bonus Standard. The Bonus fee shall be paid, at PharmaBio's
option, as follows: (i) in cash or (ii) in a number of shares of common stock of
the Company equal to the Bonus Fee multiplied by one hundred ten percent (110%)
and divided by the Share Value (as defined below).

             2.2.3    DETERMINATION OF SHARE VALUE

         The "Share Value" shall be determined pursuant to this Section 2.2.3.
Upon PharmaBio's election to be paid a Bonus Fee in common stock of the Company,
by notice thereof to the Company, the Company promptly shall propose the Share
Value and deliver to PharmaBio a description in reasonable detail of the manner
by which the Company determined the proposed Share Value, which shall be
determined as of the time the Bonus Standard is achieved. Thereafter, the
parties shall use their best efforts and negotiate in good faith to agree to the
Share Value within thirty (30) days of PharmaBio's election. If the parties
cannot agree to the Share Value within such period, then the determination of
the Share Value shall be postponed until the next round of equity financing of
the Company following the achievement of the Bonus Standard. Promptly following
such next round, the Share Value shall be determined and shall be equal to the
average of the per share purchase price of the Company's common stock (or common
stock equivalent) issued in such round and the per share purchase price of the
Company's common stock (or common stock equivalent) in the immediately preceding
round of equity financing. Should the parties be unable to agree to the Share
Value, the dispute resolution procedure set forth in Section 3.0 shall be
followed. Nothing in this Section 2.2.3 shall be construed to preclude an
agreement in writing by the parties to determine or settle the Share Value in a
manner otherwise than as provided in this Section or to provide for the payment
of the Bonus Fee in cash rather than in common stock.

         2.3 PAYMENT TERMS

         PharmaBio will invoice the Company monthly or as separately agreed for
services rendered hereunder and payment shall be made by the Company within
thirty (30) days of receipt of itemized invoices for work completed. Overdue
payments shall accrue interest at the rate of thirteen percent (13%) per annum,
and payments overdue for more than ninety (90) days shall accrue interest at the
rate of eighteen percent (18%) per annum, plus reasonable attorneys' fees and
costs incurred by PharmaBio in connection with the collection thereof.

         2.4 EXPENSES

         PharmaBio shall be reimbursed by the Company for all reasonable and
necessary travel and lodging expenses incurred in the performance of services
provided herein which have been requested or approved by the Company. Payment
for such services shall be made to PharmaBio within thirty (30) days of receipt
by the Company of invoices or other evidence of such expenditures.

                                      -4-
<PAGE>   5

3.0      DISPUTE RESOLUTION PROCEDURES
         -----------------------------

         The parties hereto recognize that a BONA FIDE dispute as to certain
matters may from time to time arise during the term of this; Agreement which
relate to a party's rights or obligations hereunder. In the event of the
occurrence of such a dispute, the parties shall through good faith negotiations
at the managerial level at which such matter arises endeavor to resolve the
dispute promptly. In the event that such dispute is not resolved promptly,
either party may, by written notice to the other party, have such dispute
referred to the review committee designated below, or their successors, and such
committee shall through good faith negotiation endeavor to resolve the dispute
by unanimous agreement of its members. The review committee shall be comprised
of five individuals, two each appointed by the Company and PharmaBio from such
party's executive officers or directors and one appointed by Warburg, Pincus,
Ventures L.P. The review committee initially shall be comprised of Clive
Meanwell, Scott Johnson, Dennis Gillings, Rachel Selisker, and Nicholas Lowcock.
In the event the review committee is not able to resolve such dispute promptly
by unanimous action, each party shall have the right to pursue any and all
remedies available at law or in equity. Neither party shall take any action
under contract or otherwise with respect to the dispute, and the Company shall
not proceed to refer any project work elsewhere for failure to obtain agreement
to perform services, without first having undertaken the foregoing procedure
with respect to the dispute and having notified the other party in writing that
it considers the dispute resolution procedures to have failed.

4.0      TERM
         ----

         This Agreement shall remain in full force and effect for a period
beginning on the date hereof and ending when PharmaBio shall have ceased
performing services under this Agreement, or any project services agreement
entered into pursuant to this Agreement, with respect to the first three
products of the Company for which PharmaBio provides services. This Agreement
may be renewed or extended by the mutual written agreement of the parties.

         Upon the termination of this Agreement, PharmaBio shall deliver to
Company all data and materials provided by Company to PharmaBio for the conduct
of services under this Agreement, except as otherwise required by applicable law
or regulation. All statistical data, all statistical reports, all data entries
and any other documentation produced as the result of services performed by
PharmaBio under the terms of this Agreement shall be delivered to Company at
such time as payment has been made to PharmaBio for all services performed.
PharmaBio reserves the right to retain one copy of all materials provided to
Company as the result of services performed by PharmaBio under this Agreement
for a period of five (5) years which will remain sealed unless a dispute arises
regarding the services performed by PharmaBio hereunder.

5.0      CONFIDENTIALITY
         ---------------

         It is understood that during the course of this Agreement, PharmaBio
and its employees may be exposed to data and information which is confidential
and proprietary

                                      -5-
<PAGE>   6

to the Company. All such data and information (hereinafter "Company Confidential
Information") written or verbal, tangible or intangible, made available,
disclosed, or otherwise made known to PharmaBio and its employees as a result of
services under this Agreement shall be considered confidential and shall be
considered the sole property of Company. All information regarding clinical
trials or clinical trial management and all information regarding PharmaBio's
operations, including but not limited to PharmaBio Property (as defined in
Section 6.0 below), disclosed by PharmaBio to the Company in connection with
this Agreement is proprietary, confidential information belonging to PharmaBio
(the "PharmaBio Confidential Information", and together with the Company
Confidential Information, the "Confidential Information"). The Confidential
Information shall be marked as confidential or otherwise represented by the
disclosing party as confidential either before or within a reasonable time after
its disclosure. The Confidential Information shall be used by the receiving
party and its employees only for purposes of performing the receiving party's
obligations hereunder. Each party agrees that it will not reveal, publish or
otherwise disclose the Confidential Information of the other party to any third
party without the prior written consent of the disclosing party, provided that
the foregoing obligations shall not apply to Confidential Information which:

                  (a) is or becomes generally available to the public other than
         as a result of a disclosure by the receiving party;

                  (b) becomes available to the receiving party on a
         non-confidential basis from a source which is not prohibited from
         disclosing such information by a legal, contractual or fiduciary
         obligation to the disclosing party;

                  (c) the receiving party develops independently of any
         disclosure by the disclosing party;

                  (d) was in the receiving party's possession or known to the
         receiving party prior to its receipt from the disclosing party; or

                  (e) is required by law to be disclosed.

         This obligation of confidentiality and non-disclosure shall remain in
         effect for a period of five years after the termination of this
         Agreement.

6.0      OWNERSHIP
         ---------

         All data and information necessary for PharmaBio to conduct project
assignments will be forwarded by the Company to PharmaBio. All data and
information generated or derived by PharmaBio as the result of services
performed by PharmaBio under this Agreement shall be and remain the exclusive
property of the Company. Any inventions that may evolve from the data and
information described above as the result of services performed by PharmaBio
under this Agreement shall belong to the Company and PharmaBio agrees to assign
all such inventions and/or patents to the Company. Notwithstanding the
foregoing, Company acknowledges that PharmaBio possesses certain inventions,
processes, know-how, trade secrets, improvements, other intellectual

                                      -6-
<PAGE>   7

properties and other assets, including but not limited to laboratory analyses,
analytical methods, procedures and techniques, computer technical expertise and
software, which have been independently developed by PharmaBio (collectively
"PharmaBio Property"). The Company and PharmaBio agree that any PharmaBio
Property or improvements thereto which are used, improved, modified or developed
by PharmaBio under or during the term of this Agreement are the product of
PharmaBio's technical expertise possessed and developed by PharmaBio prior to or
during the performance of this Agreement and are the sole and exclusive property
of PharmaBio. The Company further acknowledges that PharmaBio's professional
staff possesses certain technical expertise and conceptual expertise in area of
drug development which have been independently developed by PharmaBio. The
Company and PharmaBio agree that such technical expertise, processes, methods,
approach or analyses used, improved, modified or developed by PharmaBio under or
during the term of the Agreement or are the product of PharmaBio's technical
expertise possessed and developed by PharmaBio prior to the date of this
Agreement and are the sole and exclusive property of PharmaBio.

7.0      LIMITATION OF LIABILITY; INDEMNIFICATION
         ----------------------------------------

         7.1 LIMITATION OF LIABILITY

         Neither PharmaBio nor its affiliates nor any of its or their respective
directors, officers, employees or agents shall have any liability whatsoever
under this Agreement or otherwise except with respect to damages directly
attributable solely to PharmaBio's negligence, gross negligence or intentional
misconduct. In addition, the collective, aggregate liability of PharmaBio and
its affiliates and its and their respective directors, officers, employees and
agents under this Agreement or otherwise shall not exceed the greater of (i) the
amount of compensation actually received by PharmaBio from the Company pursuant
to this Agreement for the assignment or task from which such liability arose or
(ii) two million ($2,000,000), except with respect to damages directly
attributable solely to PharmaBio's gross negligence or intentional misconduct.
Notwithstanding the foregoing, neither PharmaBio, nor its affiliates, nor any of
its or their respective directors, officers, employees or agents shall have any
liability for any special, incidental, or consequential damages, including, but
not limited to the loss of opportunity, loss of the use of any data or
information supplied hereunder, loss of revenue or profit, in connection with or
arising out of this Agreement, the services performed by PharmaBio hereunder or
the existence, furnishing, functioning, or the Company's use of any information,
documentation or services provided pursuant to this Agreement, even if PharmaBio
shall have been advised of the possibility of such damages.

         7.2 INDEMNIFICATION

             7.2.1 COMPANY

         The Company shall indemnify, defend and hold harmless PharmaBio, its
affiliates and its and their respective directors, officers, employees and
agents (each, an "Indemnitee") from and against any and all losses, claims,
actions, damages, liabilities,

                                      -7-
<PAGE>   8

costs and expenses, (including reasonable attorneys' fees and court costs)
(collectively, "Losses"), relating to or arising from or in connection with this
Agreement (including, without limitation, any Losses arising from or in
connection with any study, test, product or potential product to which this
Agreement relates) or any litigation, investigation or other proceeding relating
to any of the foregoing, except to the extent such Losses are determined to have
resulted solely from gross negligence or intentional misconduct of the
Indemnitee seeking indemnity hereunder.

             7.2.2    PHARMABIO

         PharmaBio shall indemnify, defend and hold harmless the Company, its
affiliates and its and their respective directors, officers, employees and
agents (each, an "Indemnitee") from and against any and all losses, claims,
actions, damages, liabilities, costs and expenses, (including reasonable
attorneys' fees and court costs) (collectively, "Losses"), to the extent caused
by PharmaBio, except to the extent (i) PharmaBio is indemnified pursuant to
Section 7.2.1 hereof OR (ii) PharmaBio's liability is excluded or limited by
Section 7.1 hereof.

             7.2.3    INDEMNITOR

         For purposes of Section 7.3, the party providing indemnification
pursuant to Section 7.2 shall be referred to as the Indemnitor.

         7.3 INDEMNIFICATION PROCEDURE

         The Indemnitee shall: (a) give the Indemnitor notice of any such claim
or law suit (including a copy thereof served upon it); and (b) Indemnitee and
its employees shall fully cooperate with the Indemnitor and its legal
representatives in the investigation of any matter the subject of
indemnification; and (c) Indemnitee shall not unreasonably withhold its approval
of the settlement of any such claim, liability, or action by the Indemnitor the
subject of this Indemnification provision and the Indemnitor may unilaterally
settle any such claim so long as the Indemnitee obtains a full and complete
enforceable release from any and all liability whatsoever from all parties
making or threatening to make the claim being settled. Provided, however, that
Indemnitee's failure to comply with its obligations pursuant to this Section 7.3
shall not constitute a breach of this Agreement nor relieve the Indemnitor of
its indemnification obligations pursuant to Section 7.2, except to the extent,
if any, that the Indemnitor's defense of the affected claim, action or
proceeding actually was materially impaired thereby.

8.0      FORCE MAJEURE
         -------------

         In the event PharmaBio shall be delayed or hindered in or prevented
from the performance of any act required hereunder by reasons of strike,
lockouts, labor troubles, inability to procure materials, failure of power or
restrictive government or judicial orders, or decrees, riots, insurrection, war,
Acts of God, inclement weather or any other reason or cause beyond PharmaBio's
control, then performance of such act shall be excused for the period of such
delay. If as a result of a condition or event referred to in this Section 8.0,
PharmaBio shall be unable to perform its obligations hereunder for a

                                      -8-
<PAGE>   9

period of thirty (30) consecutive days, the Company may engage other persons to
perform services of the type contemplated by this Agreement in lieu of
PharmaBio, until such condition or event shall have ceased and PharmaBio shall
have resumed performance hereunder.

9.0      MISCELLANEOUS
         -------------

         9.1 INDEPENDENT CONTRACTOR RELATIONSHIP

         For the purposes of this Agreement, the parties hereto are independent
contractors and nothing contained in this Agreement shall be construed to place
them in the relationship of partners, principal and agent, employer/employee or
joint venturers. PharmaBio agrees that it shall have no power or right to bind
or obligate the Company, nor shall PharmaBio hold itself out as having such
authority.

         9.2 PUBLICATION

         From time to time it may be to the mutual interest of PharmaBio and the
Company to publish articles relating to services performed as a part of this
Agreement. Publication of project assignment results in whole or in part, shall
be within the sole and absolute discretion of the Company. Results may not be
published or referred to, in whole or in part, without the prior expressed
written consent of the Company. The Company reserves the unqualified right to
reject any article utilizing any data generated from PharmaBio's services under
this Agreement before such article is presented or submitted for publication.

         9.3 REVIEW OF WORK

         During the term of this Agreement, PharmaBio will permit the Company's
representative(s) to examine the work performed hereunder and the facilities at
which the work is conducted at reasonable times and in a reasonable manner to
determine that the project assignment is being conducted in accordance with the
agreed task and that the facilities are adequate.

         9.4 NOTICES

         Any notice required or permitted to be given hereunder by either party
hereunder shall be in writing and shall be deemed given on the date received if
delivered personally or three days after the date postmarked if sent by
registered or certified U.S. mail, return receipt requested, postage prepaid or
by nationally recognized overnight delivery service to the following addresses:

         If to PharmaBio:      Gregory D.  Porter, Esq.
                               PharmaBio Development Inc.
                               P.O.  Box 13979
                               Research Triangle Park, North Carolina 27709-3979

                                      -9-
<PAGE>   10

         with a copy to:       Gerald F.  Roach, Esq.
                               Smith, Anderson, Blount, Dorsett, Mitchell &
                               Jernigan, L.L.P.
                               2500 First Union Capitol Center
                               Raleigh, North Carolina 27601

         If to Company:

         9.5 BINDING AGREEMENT; ASSIGNMENT; PARTIES IN INTEREST

         This Agreement shall be binding upon and inure to the benefit of
Company and PharmaBio and their respective successors and permitted assigns.
Neither this Agreement nor any of either party's rights hereunder may be
assigned or otherwise transferred by either party without the prior written
consent of the other; provided, however, PharmaBio may in its sole discretion
assign at any time any or all of its rights and obligations under this Agreement
to any of its corporate affiliates or may utilize any such affiliates to carry
out its obligations under this Agreement. Each party hereto intends that this
Agreement shall not benefit or create any right or cause of action in or on
behalf of any person other than the Company or PharmaBio.

         9.6 GOVERNING LAW; SEVERABILITY

         This Agreement shall be construed, governed, interpreted, and applied
in accordance with the laws of the State of North Carolina. If any one or More
provisions of this Agreement shall be found to be illegal or unenforceable in
any respect, the validity, legality and enforceability of the remaining
provisions shall not in any way be affected or impaired thereby.

         9.7 SURVIVAL

         The obligations of the parties contained in Sections 5.0, 6.0, 7.0 and
9.2 hereof, shall survive the termination of this Agreement.

         9.8 ENTIRE AGREEMENT

         This Agreement contains the entire understandings of the parties with
respect to the subject matter herein, and supersedes all previous Agreements
(oral and written), negotiations and discussions.

         9.9 AMENDMENT AND WAIVER

         Neither this Agreement nor any of the terms or provisions hereof may be
(a) amended, modified or supplemented except by a written instrument signed by
both parties; or (b) waived except by written instrument signed by the party
against whom such waiver is sought to be enforced.

                                      -10-
<PAGE>   11

         9.10 GUARANTY

         This Agreement shall be executed by Quintiles, Inc., a North Carolina
corporation and a wholly owned subsidiary of Quintiles Transnational Corp.
solely for the purpose of guaranteeing by such execution the payment obligations
of PharmaBio under Section 7 of this Agreement.

                                      -11-
<PAGE>   12

         IN WITNESS WHEREOF, the Company, PharmaBio and Quintiles, Inc. (solely
to the extent indicated), by authority duly given, have executed this Agreement
as of the day and year first above written.

                                      MEDICINES DEVELOPMENT COMPANY

                                      By: /s/ Clive A. Meanwell
                                         ---------------------------------
                                      Name: Clive A. Meanwell
                                           -------------------------------
                                      Title: President
                                            ------------------------------

                                      PHARMABIO DEVELOPMENT INC.

                                      By: /s/ Rachel R. Selisker
                                         ---------------------------------
                                      Name: Rachel R. Selisker
                                           -------------------------------
                                      Title: VP Finance
                                            ------------------------------

                                      QUINTILES, INC., SOLELY FOR THE PURPOSE OF
                                      SECTION 9.10

                                      By: /s/ Rachel R. Selisker
                                         ---------------------------------
                                      Name: Rachel R. Selisker
                                           -------------------------------
                                      Title: Treasurer
                                            ------------------------------

                                      -12-
<PAGE>   13

         For the purposes of agreeing and consenting to the issuance of stock by
the Company to PharmaBio as contemplated by this Agreement, the undersigned
parties hereby agree and consent to the stock issuances contemplated hereby,
with authority duly given. Without limiting the foregoing, the undersigned agree
that any such issuance of stock shall not be subject to any subscription or
participation rights provisions of the Stockholders' Agreement referred to in
the Purchase Agreement.

                                      MEDICINES DEVELOPMENT COMPANY

                                      By: /s/ Clive A. Meanwell
                                         ---------------------------------
                                      Name: Clive A. Meanwell
                                           -------------------------------
                                      Title: President
                                            ------------------------------

                                      PHARMABIO DEVELOPMENT INC.

                                      By: /s/ Rachel R. Selisker
                                         ---------------------------------
                                      Name: Rachel R. Selisker
                                           -------------------------------
                                      Title: VP Finance
                                            ------------------------------

                                      WARBURG, PINCUS, VENTURES L.P.

                                      By: /s/ James E. Thomas
                                         ---------------------------------
                                      Name: James E. Thomas
                                           -------------------------------
                                      Title: Partner
                                            ------------------------------

                                      MPM MEDICINES L.P.

                                      By: /s/ Ansbert Gadicke
                                         ---------------------------------
                                      Name: Ansbert Gadicke
                                           -------------------------------
                                      Title:
                                            ------------------------------

                                      HANSEATIC AMERICAS LDC

                                      By: Hansabel Partners, LLC
                                          Managing Member

                                      By: /s/ Paul Biddleman
                                         ---------------------------------
                                      Name: Paul Biddleman
                                           -------------------------------
                                      Title: Treasurer, Hanseatic
                                             Corporation
                                            ------------------------------

                                      /s/ Clive A. Meanwell
                                      ------------------------------------
                                      Clive Meanwell

                                      /s/ T. Scott Johnson
                                      ------------------------------------
                                      Scott Johnson

                                      /s/ Ansbert Gadicke
                                      ------------------------------------
                                      Ansbert Gadicke

                                      -14-
<PAGE>   14

                         AMENDMENT TO ALLIANCE AGREEMENT

     This Amendment to Alliance Agreement ("this Amendment"), dated this 15th
day of December, 1997, is by and between The Medicines company (formerly known
as Medicines Development Company, (the "Company")) and PharmaBio Development
Inc. ("PharmaBio").

                                    Recitals:

     The Company and PharmaBio entered into that certain Alliance Agreement,
effective August, 1996 (the "Agreement"), pursuant to which the parties agreed
to certain matters relating to PharmaBio's provision of pharmaceutical support
services. Section 1.3 of the Agreement contemplates the execution of separate
agreements to evidence project-specific engagements; however, the parties desire
to amend the Agreement to serve as a vehicle for the Company's engagement of and
contracting for one or more project with PharmaBio, as more fully set forth
herein.

                                   Agreement:

     In consideration of the mutual agreements set forth herein and other good
and valuable consideration, the receipt and sufficiency of which are hereby
acknowledged, PharmaBio and the Company hereby agree as follows:

     1.   AMENDMENT TO SECTION 1.3. Section 1.3 of the Agreement is hereby
amended by deleting existing Section 1.3 in its entirety and by substituting the
following in its place:

     1.3  WORK ORDERS FOR PROJECT SERVICES. The following provisions shall apply
with respect to project services rendered pursuant to Section 1.2:

     (a)  This Agreement is intended to constitute a "master" form of contract
          which allows PharmaBio and the Company to contract for multiple
          projects under Section 1.2 through the issuance of multiple Work
          Orders (as defined below). The specific details of each project under
          Section 1.2 of this Agreement (each, a "Project") shall be separately
          negotiated and specified in writing on terms and in a form acceptable
          to the parties (each such writing, a "Work Order"). Each Work Order
          will include, as appropriate, the Project protocol, scope of work,
          timeline, budget, and payment schedule, Each Work Order shall be
          subject to all of the terms and conditions of this Agreement, in
          addition to the specific details set forth in the Work Order.

     (b)  The Company will pay PharmaBio for fees, expenses and pass-through
          costs in accordance with the specific provisions of each Work Order.
          Unless otherwise agreed in a particular Work Order, the following
          shall apply; (a) the total fees for a particular Project will not
          exceed the budget applicable to such Project and attached to the Work
          Order; (b) PharmaBio shall be reimbursed by the Company for all
          reasonable and necessary expenses and pass-through costs incurred in
          the performance of the Services; and (c) PharmaBio will invoice the
          Company monthly for the

<PAGE>   15

          fees, expenses and pass-through costs relating to the Project and
          payment shall be made by the Company within thirty (30) days of
          receipt of each monthly itemized invoice.

     (c)  Any change in the details of a Work Order (including, but not limited
          to, changes in the Project's scope and/or any one or number of the
          duties, responsibilities and tasks undertaken by PharmaBio) shall
          require a written Change Order (herein so called) in a form acceptable
          to both parties. Either party may request or initiate a Change Order.
          Both parties agree to act in good faith and promptly when considering
          a Change Order requested by the other party and will not unreasonably
          withhold approval of a requested change order.

     (d)  If a particular Work Order obligates PharmaBio to contract with
          investigators of investigative sites (collectively, "Investigators")
          or facilitate the Company's contracting with Investigators (or other
          independent contractors such as central laboratories), then any such
          contact shall be on a form mutually acceptable to PharmaBio and the
          Company. The Company acknowledges that an Investigator engaged for a
          particular Project shall be solely responsible for his or her (or its)
          own independent medical judgment and his or her (or its) acts and
          omissions in performing the clinical investigation and related
          services.

     (e)  An individual Work Order under this Agreement may be terminated
          without cause by the Company or by PharmaBio at any time during the
          term of the Work Order on forty-five (45) days prior written notice to
          PharmaBio or the Company as appropriate. An individual Work Order may
          also be terminated immediately by a non-breaching party upon a
          material breach of the Work Order or this Agreement by the other
          party; provided, however, such termination right shall not be allowed
          unless the non-breaching party provides thirty (30) days prior written
          notice indicating the specific breach and the breaching party does not
          cure within the thirty day notice period or initiate a cure in good
          faith within the thirty day notice period and effect such cure within
          sixty days after expiration of the thirty day notice period. In the
          event a Work Order is terminated other than a result of breach by
          PharmaBio, the Company's sole obligation to PharmaBio with respect to
          the impacted Project(s) shall be (a) to pay PharmaBio any fees for
          Services rendered through the termination date, and (b) to pay all
          actual costs to complete activities associated with the termination
          and close out of Projects.

     (f)  The Company agrees that PharmaBio may utilize the Services of its
          corporate affiliates to fulfill PharmaBio's obligations under this
          Agreement and any Work Order. Any affiliate so utilized shall be (i)
          subject to all of the terms and conditions applicable to PharmaBio
          under this Agreement and the Work Order applicable to such Project(s),
          including, but not limited to, provisions establishing the standards
          for performance, and (ii) entitled to all rights and protections
          afforded PharmaBio under this Agreement and the Work Order applicable
          to such

                                      -2-

<PAGE>   16

          Project(s), including, but not limited to, the indemnity and
          limitation of liability protections set forth herein. Any such
          affiliate of PharmaBio may execute a Work Order directly and, with
          respect to the corresponding Project, the rights and obligations of
          the parties shall be governed by all of the terms and conditions of
          this Agreement, to the same extent as if such affiliate was a party to
          this Agreement.

     (g)  The standards, rights and obligations of the parties set forth in
          Sections 1.4, 2, 3, 4, 5, 6, 7, 8, and 9 of this Agreement shall be
          applicable to every Work Order performed under this Agreement, unless
          the Work Order expressly and specifically states an intent to
          supersede this Agreement on a specific matter (but the only with
          respect to such matter and the specific Work Order).

     2.   CORRESPONDING AMENDMENTS. Any provisions in the Agreement in conflict
with this Amendment with respect to the ability to issue Work Orders for
Projects under the Agreement shall be deemed superseded by this Amendment.

     3.   EFFECT ON THE AGREEMENT. The Company and PharmaBio acknowledge that
the Agreement (as amended hereby) (i) is in full force and effect and shall
control PharmaBio's provision of services and the related rights and obligations
of PharmaBio and the Company with respect to Projects, and (ii) shall continue
to control the rights and obligations of the Company and PharmaBio with respect
to the original matters addressed therein.

     4.   COUNTERPARTS. This Amendment may be executed in multiple counterparts,
all of which taken together shall constitute on agreement.

     The parties have executed this Amendment effective as of the date first
written above.

THE MEDICINES COMPANY                   PHARMABIO DEVELOPMENT INC.

By: /s/ Clive A. Meanwell               By:          illegible
   ---------------------------------       ----------------------------------
Name: Clive A. Meanwell                 Name:
     -------------------------------          -------------------------------
Title: President                        Title:
      ------------------------------          -------------------------------

                                      -3-

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