Document:

Supplemental Indenture

 Exhibit 4.6 
 SUPPLEMENTAL INDENTURE 
 SUPPLEMENTAL INDENTURE (this “Supplemental
Indenture”) dated as of February 29, 2012, among NCL CORPORATION LTD. (or its successor), a company organized under the laws of Bermuda (the “Issuer”), and U.S. BANK NATIONAL ASSOCIATION, a national banking association, as
trustee under the indenture referred to below (the “Trustee”). 
 W I T N E S S E T H: 

WHEREAS, the Issuer has heretofore executed and delivered to the Trustee an indenture (as amended, supplemented or otherwise modified,
the “Indenture”) dated as of November 9, 2010, providing for the issuance of the Issuer’s 9.50% Senior Notes due 2018 (the “Existing Notes”), initially in the aggregate principal amount of $250,000,000;

 WHEREAS, the Issuer desires to issue an additional $100,000,000 aggregate principal amount of such Notes (the
“Additional Notes”, together with the Existing Notes and any future Additional Notes, the “Notes”) pursuant to Section 2.01 of the Indenture, and in furtherance thereof to execute and deliver this
Supplemental Indenture in accordance with Section 9.01 of the Indenture; 
 WHEREAS, Section 9.01(a)(xii) of the
Indenture provides that a supplemental indenture may be entered into by the Issuer and the Trustee without the consent of any Holders to establish Additional Notes as permitted by Section 2.01 of the Indenture; 

WHEREAS, pursuant to Section 9.01 of the Indenture, the Issuer and the Trustee are authorized to execute and deliver this
Supplemental Indenture; 
 NOW, THEREFORE, in consideration of the premises and the purchase and acceptance of the Notes by the
holders thereof, the Issuer covenants and agrees with the Trustee, for the equal and ratable benefit of the Holders, that the Indenture is supplemented and amended, to the extent expressed herein, as follows: 

ARTICLE I 

DEFINITIONS 

SECTION 1.1 Defined Terms. Capitalized terms used herein without definition shall have the meanings assigned to them in the
Indenture. 
 ARTICLE II 
 ADDITIONAL NOTES 
 SECTION 2.1 Additional Notes. The Issuer shall issue the
Additional Notes under the Indenture, subject to compliance with the terms thereof, with such Additional Notes to have identical terms to those of the Existing Notes; provided, that the Additional Notes shall (i) be subject to a separate
Registration Rights Agreement dated the date hereof, (ii) have a date of issuance of February 29, 2012, (iii) have an issue price of 106.000%, plus accrued interest from and including November 15, 2011 and (iv) the
Additional Notes shall initially be in the form of one or more Restricted Global Notes and shall initially bear a separate CUSIP number from the Existing Notes. 

 SECTION 2.2 Other Terms of the Notes. Without limiting the foregoing provisions of
this Supplemental Indenture, the terms of the Additional Notes shall be as provided in the Indenture, as supplemented hereby. 

ARTICLE III 

MISCELLANEOUS 

SECTION 3.1 Governing Law. THIS SUPPLEMENTAL INDENTURE SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE
STATE OF NEW YORK, WITHOUT REGARD TO PRINCIPLES OF CONFLICTS OF LAW. 
 SECTION 3.2 Severability. In case any provision
in this Supplemental Indenture shall be invalid, illegal or unenforceable, the validity, legality and enforceability of the remaining provisions shall not in any way be affected or impaired thereby and such provision shall be ineffective only to the
extent of such invalidity, illegality or unenforceability. 
 SECTION 3.3 Ratification of Indenture; Supplemental Indentures
Part of Indenture. Except as expressly amended hereby, the Indenture is in all respects ratified and confirmed and all the terms, conditions and provisions thereof shall remain in full force and effect. This Supplemental Indenture shall form a
part of the Indenture for all purposes, and every Holder of Notes heretofore or hereafter authenticated and delivered shall be bound hereby. 
 SECTION 3.4 Counterparts. The parties may sign any number of copies of this Supplemental Indenture. Each signed copy shall be an original, but all of them together represent the same agreement. One
signed copy is enough to prove this Supplemental Indenture. 
 SECTION 3.5 Headings. The headings of the Articles and
Sections of this Supplemental Indenture have been inserted for convenience of reference only, are not to be considered a part of this Supplemental Indenture and shall in no way modify or restrict any of the terms or provisions hereof. 

[Signature Pages Follow] 

  
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 IN WITNESS WHEREOF, the parties hereto have caused this Supplemental Indenture to be duly
executed as of the date first above written. 
  

			
	NCL CORPORATION LTD.
		
	By:	 	                /S/ Wendy A. Beck
		 	 Name:  Wendy A. Beck

Title:    Executive Vice President and

Chief Financial Officer

 
			
	U.S. BANK NATIONAL ASSOCIATION
		
	By:	 	                /S/ Joshua A. Hahn
		 	 Name:  Joshua A. Hahn

Title:    Assistant Vice PresidentSixth Amendment to Lease Agreement

 Exhibit 10.1 
 SIXTH AMENDMENT 
 THIS SIXTH AMENDMENT (the “Amendment”)
is made and entered into as of March 19, 2012, by and between 4350 LA JOLLA VILLAGE LLC, a Delaware limited liability company, (“Landlord”) and MEDICINOVA, INC., a Delaware corporation (“Tenant”).

 RECITALS 
  

	A.	 Landlord and Tenant are parties to that certain lease dated January 28, 2004, which lease has been previously amended by a First Amendment dated
August 10, 2004, a Second Amendment dated March 21, 2005, a Third Amendment dated January 31, 2008, Fourth Amendment dated October 3, 2008, and a Fifth Amendment dated July 6, 2011 (collectively, the
“Lease”). Pursuant to the Lease, Landlord has leased to Tenant space currently containing approximately 5,089 rentable square feet described as Suite No. 950 (the “Premises”), on the 9th floor of the building located at 4350 La Jolla Village Drive, San
Diego, California (the “Building”). 

  

	B.	The Lease by its terms shall expire on May 31, 2012 (“Fourth Prior Termination Date”), and the parties desire to extend the Term of the Lease all
on the following terms and conditions. 

 NOW, THEREFORE, in consideration of the above recitals which by
this reference are incorporated herein, the mutual covenants and conditions contained herein and other valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant agree as follows: 

 

	I.	Extension. The Term of the Lease is hereby extended and shall expire on February 28, 2013 (“Fourth Extended Termination Date”),
unless sooner terminated in accordance with the terms of the Lease. That portion of the Term commencing the day immediately following the Fourth Prior Termination Date (“Fourth Extension Date”) and ending on the Fourth Extended
Termination Date shall be referred to herein as the “Fourth Extended Term”. 

  

	II.	Base Rent. As of the Fourth Extension Date, the schedule of Base Rent payable with respect to the Premises during the Fourth Extended Term is the
following: 

  

									
	 Months of Term or Period
	  	Monthly Rate Per
Square Foot	 	  	Monthly Base Rent	 
	 6/1/12 – 2/28/13
	  	$	2.49	  	  	$	12,672.00	  

 All such Base Rent shall be payable by Tenant in accordance with the terms of the Lease. 

 

	III.	Expenses and Taxes. For the period commencing on the Fourth Extension Date and ending on the Fourth Extended Termination Date, Tenant shall be obligated
to pay Tenant’s Pro Rata Share of Expenses and Taxes accruing in connection with the Premises in accordance with the terms of the Lease. 

  

	IV.	Security Deposit. No additional security deposit shall be required in connection with this Amendment. 

 

	V.	Improvements to Premises. 

  

	 	A.	Condition of Premises. Tenant is in possession of the Premises and accepts the same “as is” without any agreements, representations, understandings or
obligations on the part of Landlord to perform any alterations, repairs or improvements, except as may be expressly provided otherwise in this Amendment. 

  

	 	B.	Any construction, alterations or improvements to the Premises shall be performed by Tenant at its sole cost and expense using contractors selected by Tenant and
approved by Landlord and shall be governed in all respects by the provisions of Section 9.03 of the Lease. 

 VI.
Parking. Notwithstanding any contrary provision in Exhibit G to the Lease, “Parking Agreement,” as amended, effective as of the Fourth Extension Date, Landlord shall lease to Tenant, and Tenant shall lease from Landlord, a
minimum of 15, but no more than 17, unreserved parking spaces in the Parking Facility at the rate of $55.00 per stall per month through the Fourth Extended Term. 
  

	VII.	SDN List. Tenant hereby represents and warrants that neither Tenant nor any officer, director, employee, partner, member or other principal of Tenant
(collectively, “Tenant Parties”) is listed as a Specially Designated National and Blocked Person (“SDN”) on the list of such persons and entities issued by the U.S. Treasury Office of Foreign Assets Control
(“OFAC”). In the event Tenant or any Tenant Party is or becomes listed as an SDN, Tenant shall be deemed in breach of this Lease and Landlord shall have the right to terminate the Lease immediately upon written notice to Tenant.

  
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	VIII.	GENERAL. 

  

	 	A.	Effect of Amendments. The Lease shall remain in full force and effect except to the extent that it is modified by this Amendment. 

 

	 	B.	Entire Agreement. This Amendment embodies the entire understanding between Landlord and Tenant and can be changed only by a writing signed by Landlord and
Tenant. There have been no additional oral or written representations or agreements. Under no circumstances shall Tenant be entitled to any rent abatement, improvement allowance, leasehold improvements, or any similar economic incentives that may
have been provided Tenant in connection with entering into the Lease, unless specifically set forth in this Amendment. 

  

	 	C.	Counterparts. If this Amendment is executed in counterparts, each is hereby declared to be an original; all, however, shall constitute but one and the same
amendment. In any action or proceeding, any photographic, photostatic, or other copy of this Amendment may be introduced into evidence without foundation. 

  

	 	D.	Defined Terms. All words commencing with initial capital letters in this Amendment and defined in the Lease shall have the same meaning in this Amendment as in
the Lease, unless they are otherwise defined in this Amendment. 

  

	 	E.	Authority. If Tenant is a corporation, limited liability company or partnership, or is comprised of any of them, each individual executing this Amendment for the
corporation, limited liability company or partnership represents that he or she is duly authorized to execute and deliver this Amendment on behalf of such entity and that this Amendment is binding upon such entity in accordance with its terms.

  

	 	F.	Attorneys’ Fees. The provisions of the Lease respecting payment of attorneys’ fees shall also apply to this Amendment. 

 

	 	G.	Execution of Amendment. Submission of this Amendment by Landlord is not an offer to enter into this Amendment but rather is a solicitation for such an offer by
Tenant. Landlord shall not be bound by this Amendment until Landlord has executed and delivered the same to Tenant. 

  

	 	H.	Nondisclosure of Terms. Except (i) as required by law; (ii) in connection with a dispute or litigation hereunder; (iii) as required by subpoena;
or (iv) pursuant to regulations and statutes for publicly traded entities, Tenant agrees that neither Tenant nor its agents or any other parties acting on behalf of Tenant shall disclose any matters set forth in this Amendment or disseminate or
distribute any information concerning the terms, details or conditions hereof to any person, firm or entity without obtaining the express written consent of Landlord, which consent will not be unreasonably withheld, conditioned or delayed. Landlord
acknowledges that Tenant is required to file this Amendment with the Securities Exchange Commission. 

 IN
WITNESS WHEREOF, Landlord and Tenant have duly executed this Amendment as of the day and year first above written. 
  

									
	LANDLORD:	 		 	TENANT:
			
	 4350 LA JOLLA VILLAGE LLC,
 a Delaware limited liability company
	 		 	 MEDICINOVA, INC.,
 a Delaware corporation

					
	By:	 	 /s/ Steven M. Case
	 		 	By:	 	 /s/ MICHAEL D. COFFEE

		 	Steven M. Case	 		 	Printed Name:	 	MICHAEL D. COFFEE
		 	Executive Vice President	 		 	Title:	 	Chief Business Officer
		 	Office Properties	 		 		 	
					
	By:	 	 /s/ Michael T. Bennett
	 		 	By:	 	 /s/ Kirk Johnson

		 	Michael T. Bennett	 		 	Printed Name:	 	Kirk Johnson
		 	Senior Vice President, Operations	 		 	Title:	 	CSO
		 	Office Properties	 		 		 	

  
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