Document:

Exhibit 10.4

 

CERTAIN CONFIDENTIAL PORTIONS OF THIS EXHIBIT WERE OMITTED AND REPLACED WITH “[...***...].” A COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECRETARY OF THE U.S. SECURITIES AND EXCHANGE COMMISSION PURSUANT TO AN APPLICATION REQUESTING CONFIDENTIAL TREATMENT PURSUANT TO RULE 24b-2 UNDER THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

 

Supplemental Agreement to the Entrusted Loan Contract

 

Borrower (Party A): BeiGene (Suzhou) Co., Ltd.

Telephone:

Domicile: E105, 2F, A1 North, 218 Xinghu Rd.

Fax:

Legal representative: John Victor Oyler

 

Entrusted Lender (Party B): Suzhou Industrial Park Biotech Development Co., Ltd.

Telephone: 62956633

Domicile: 5F, A1 North, 218 Xinghu Rd.

Fax:

Legal representative: Pang Junyong

Post code: 215123

 

Agency (Party C): China Construction Bank Suzhou Industrial Park Branch

Telephone: 62781038

Domicile: 8/F, CSSD Building, No. 158 Wangdun Road

Responsible person: Wu Nandai

Post code: 215028

 

Party A, Party B and Party C entered into an Entrusted Loan Contract (Entrusted Loan [2015] No. 013) on September 2, 2015 (the “Original Contract”).  The three parties hereby agree to amend the following provisions by mutual agreement:

 

1. In “Clause VI  Guarantee on the Loan” of the Original Contract, “The way of guarantee to be adopted for the entrusted loan under the Contract will be the type (II) below:

 

(I)  Party B will sign the Guarantee Contract by its own.

(II) Party B commissions Party C to sign the Guarantee Contract in the name of the latter.”

 

shall be amended as follows:

 

“The way of guarantee to be adopted for the entrusted loan under the Contract will be the type (I) below:

 

(I) Party B will sign the Guarantee Contract by its own.

(II) Party B commissions Party C to sign the Guarantee Contract in the name of the latter.”

 

2. Paragraph (II), (III) and (IV) of “XII (Miscellaneous)” under “Clause XIV Miscellaneous” of the Original Contract:

 

“(II)  Party A confirms: the completion of the pledge registration procedure for [...***...] patent guaranteed by BeiGene (Beijing) Co., Ltd. will not be later than June 30, 2016, otherwise Party B will be entitled to terminate the Contract and request Party A repaying in advance. Party A shall complete the subsequent fundraising by itself and mortgage the fixed assets purchased by the fund raised by itself to Party B.

 

* Confidential Information, indicated by [...***...], has been omitted from this filing and filed separately with the U.S. Securities and Exchange Commission.

 

 

(III) The mortgage registration procedure for the equipment purchased by Party A after acquiring the first batch of loan (RMB 60,000,000) guaranteed should be completed no later than June 30, 2016, otherwise Party B will be entitled to terminate the Contract and request Party A repaying in advance.  Party A shall complete the subsequent fundraising by itself and mortgage the fixed assets purchased by the fund raised by itself to Party B.

 

(IV) The equipment purchased by Party A with the rest RMB 60,000,000 shall also be mortgaged to Party B. Party A shall conduct the mortgage registration procedure within 2 months after obtaining the ownership of the equipment.  If Party A fails to actively assist with Party B in handling the mortgage registration procedure, Party B will be entitled to terminate the Contract and request Party A repaying in advance.”

 

shall be amended as follows:

 

“(II) After the ownership of the equipment purchased with the loan is obtained or after the relevant renovation is finished, Party A shall, within 2 months after obtaining ownership of the equipment, mortgage the equipment and relevant renovation to Party B to the maximum extent that is acceptable to the competent mortgage registration authority.  Party A shall be responsible for, and Party B and Party C shall cooperate in handling the mortgage registration procedures for the equipment, etc.  The mortgage registration procedures shall be completed no later than December 31, 2016; otherwise, Party B will be entitled to terminate the Contract and request Party A to make early repayment of any loans that it has already received.  In the meantime, Party A shall complete the subsequent financing on its own and mortgage the fixed assets purchased through self-financing as the first mortgage to Party B to the maximum extent acceptable to the competent mortgage registration authority (no later than June 30, 2017).

 

(III) Party A acknowledges that the [...***...] patent obtained by Beigene Ltd. (the “Cayman Company”) will be pledged to Party B, and the pledge registration for such patent will be completed by July 30, 2016 in accordance with the Patent Pledge Contract to be entered into by the Cayman Company and Party B.  Within 2 months after the Cayman Company or its subsidiary obtains the certificate of patent issued by the State Intellectual Property Office (SIPO) of China for the [...***...] patent, the patent will be pledged to Party B and the pledge registration with the SIPO will be completed.  After the pledge registration and the relevant procedure for the [...***...] patent are completed, the parties will work together to cancel the pledge registration for the [...***...] patent.  In case of failure to complete the pledge registration for the [...***...] patent by July 30, 2016, Party B will be entitled to terminate the Contract and request Party A to make early repayment any loans that it has already received.  In the meantime, Party A shall complete the subsequent financing on its own and mortgage the fixed assets purchased through self-financing to Party B to the maximum extent acceptable to the competent mortgage registration authority (no later than June 30, 2017).”

 

This Supplemental Agreement shall constitute a supplement and amendment to the Original Contract.  All provisions of the Original Contract that are not amended shall remain in force and effect.  In case of any discrepancy between the Original Contract and this Supplemental Agreement, this Supplemental Agreement shall prevail.

 

* Confidential Information, indicated by [...***...], has been omitted from this filing and filed separately with the U.S. Securities and Exchange Commission.

 

 

This Supplemental Agreement shall become effective after the legal representatives (responsible persons) or authorized agents of all parties hereto sign or affix a seal to it, and affix the official seals of all parties to it.

 

This Supplemental Agreement shall be made in six counterparts, with each party holding two counterparts.

 

Party A (official seal):

Signature of Legal Representative (Responsible Person) or Authorized Agent:

 

Party B (official seal):

Signature of Legal Representative (Responsible Person) or Authorized Agent:

 

Party C (official seal):

Signature of Legal Representative (Responsible Person) or Authorized Agent:

 

Date Signed: June 11, 2016Exhibit 10.1

 

August 4, 2016

 

Arthur H. Tinkelenberg,
Ph.D.

c/o Enumeral Biomedical
Holdings, Inc.

200 CambridgePark Drive,
Suite 2000

Cambridge, MA 02140

 

Dear Arthur:

 

This letter agreement
(the “Letter Agreement”) confirms that your employment with Enumeral Biomedical Holdings, Inc. (with its subsidiaries,
the “Company”) has ceased effective July 28, 2016 and sets forth the terms of your separation from service as
an employee of the Company. You and the Company acknowledge and agree that this separation concerns only your employment as President
and Chief Executive Officer of the Company, and that you remain a director of the Company. Upon your termination as an employee
of the Company, and in your continued capacity as a non-employee director of the Company, you will be entitled to participate in
the Company’s Non-Employee Director Compensation Program, as may be revised from time to time by the Company’s Board
of Directors or the Compensation Committee thereof. Notwithstanding anything herein to the contrary, pursuant to this letter you
also hereby resign from any positions you hold as an officer and/or director of Enumeral Biomedical Corp. and Enumeral Securities
Corporation, both of which are subsidiaries of the Company, and you agree to execute letters of resignation from such posts in
forms acceptable to the Company.

 

In this Letter Agreement,
reference is occasionally made to that certain Amended and Restated Employment Agreement, dated as of July 21, 2014, between you
and Enumeral Biomedical Corp., a subsidiary of the Company, as assumed by the Company on July 31, 2014 (the “Amended Employment
Agreement”). The Company hereby advises you to consult with an attorney of your own choosing prior to signing this Letter
Agreement. You and the Company have agreed to the following terms:

 

Separation Date

 

1.          Your
last day of employment and your payroll termination date (i.e., the last working day for which you will be paid your base salary
and benefits) is July 28, 2016 (“Separation Date”).

 

Payments and Benefits

 

2.          Following
your execution of this Letter Agreement and the expiration of any revocation period, and your return of Company property pursuant
to Paragraph 10 below, you will receive severance payments equal to twelve (12) months of base pay denominated in United States
Dollars, totaling $262,500, less deductions pursuant to applicable tax withholding laws and regulations (the “Severance
Payment”), which will be made as salary continuation over a 12 month period by automatic payroll processing (such 12
month period following the Separation Date, the “Severance Period”). The amount of this Severance Payment will
be reflected in your IRS Form W-2 from the Company, and the Company makes no representation or warranty regarding the taxability
of any portion of the Severance Payment. You agree that you will bear responsibility for any and all taxes, penalties, or interest
that may be assessed by any taxing authority on the Severance Payment. In the event that there occurs a Change of Control of the
Company (as such term is defined in the Amended Employment Agreement) during the Severance Period, the remaining then-unpaid portion
of the Severance Payment shall be paid in a lump sum amount to you on the next regularly scheduled payroll date following the closing
of the transaction that triggered such Change of Control, in lieu of any further salary continuation payments; provided, however,
that in all events you remain bound by the provisions of this Letter Agreement, including the restrictions set forth in Paragraph
11, and in the event you violate those restrictions following a Change of Control, you will be required to repay such lump sum
payment to the Company.

 

     

     

    

 

3.          You
acknowledge that you did not elect coverage under, and thus are not currently enrolled in, any medical, dental and/or prescription
benefit plans with the Company. Consequently, you further acknowledge that you are not eligible for continuing participation in
any of the Company’s medical, dental and/or prescription benefit plans pursuant to Section 4980B of the Internal Revenue
Code of 1986, as amended (“COBRA”). In addition, the Company will pay you a lump sum amount of $10,000, less withholding
of all applicable federal, state and local taxes, to be used for any purpose you choose, including, but not limited to, purchase
of life insurance, disability insurance, or other health coverage. Such payment will be made on the Company’s first payroll
date that is at least ten (10) days after the expiration of the Revocation Period described in Paragraph 17(v) below.

 

4.          Except
as otherwise provided herein, and regardless of whether you decide to sign this Letter Agreement, your final wages and unused vacation
accrued through the Separation Date will be paid to you on the Separation Date.

 

5.          All
options to purchase shares of the Company’s common stock and restricted stock grants in the Company held by you or in a trust
established by you for the benefit of your spouse, children or heirs that are unvested as of the Separation Date shall continue
to vest during the Severance Period pursuant to the vesting schedules set forth in such option agreements and restricted stock
agreements, as applicable. In the event that you breach the terms of this Letter Agreement during the Severance Period, all unvested
options and restricted stock awards as of the date of notice by the Company of such breach (subject to any cure periods) shall
be immediately cancelled and forfeited. In the absence of such breach, all remaining unvested options and shares of restricted
stock shall fully vest and become exercisable on the expiration of the Severance Period, and the period for exercising all such
options to purchase common stock of the Company shall be extended to the date that is five (5) years following the expiration of
the Severance Period. In addition, if there occurs a Change of Control of the Company (as such term is defined in the Amended Employment
Agreement) during the Severance Period, then notwithstanding the foregoing all of your unvested shares of restricted stock and
options to purchase common stock of the Company shall immediately accelerate and become fully vested and exercisable.

 

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6.          All
other benefit programs to which you were entitled during your employment with the Company and under which you had elected coverage
shall cease as of the Separation Date.

 

7(a).     Except
as specifically provided in this Letter Agreement, you understand and agree that you are not entitled to any further salary, vacation
pay, sick pay, bonus, severance pay, compensation of any kind, retirement, health insurance, long-term disability, AD&D, life
insurance, or any other benefits. All such compensation and benefits shall cease as outlined above. However, you will retain your
rights, if any, to retirement benefits to the extent you are eligible for them pursuant to applicable plan documents. You also
agree that you have reconciled all outstanding business expenses, provided, however, that the Company is processing and will reimburse
you for the expenses you have submitted to the Company’s Vice President of Finance on your final expense reports in your
capacity as an employee of the Company.

 

(b).       Adequacy
of Consideration. You acknowledge and agree that the Company’s Severance Payment under Paragraph 2, and payment provided
under Paragraph 3 (collectively referred to as “Severance Benefits”):

 

(i)        Are
not required by any policy, plan or prior agreement;

 

(ii)       Constitute
adequate consideration to support your General Release in Paragraph 14(a) below; and

 

(iii)       Fully
compensate you for the Claims you are releasing.

 

For purposes of this
paragraph, “consideration” means something of value to which you are not already entitled.

 

Confidentiality
Provisions

 

8.          Confidentiality
of this Agreement. Because the information in this Letter Agreement is confidential, it is agreed that you will not disclose
the terms of this Letter Agreement to anyone, except (i) your family, attorney and/or accountant with whom you choose to consult
regarding this Letter Agreement, provided they each agree to the terms of confidentiality set forth herein or as required by law;
(ii) in connection with any claim to enforce, interpret or determine the scope, meaning, enforceability or effect of the Agreement;
(iii) to obtain confidential legal, tax or financial advice with respect thereto; or (iv) in connection with any of your Retained
Rights as set forth in Paragraph 16 below. You agree and affirm that you have complied with and will continue to comply with the
restrictions on the use of proprietary information set forth in Section 5 of the Amended Employment Agreement.

 

9.          Prohibition
on Your Using or Disclosing Confidential Information. Regardless of whether you sign this Agreement, and in accordance with
your Amended Employment Agreement, you are prohibited from using or disclosing confidential information which you created or acquired
in the course of your employment with the Company and which is not generally known by or readily accessible to the public. This
confidential information includes, without limitation, the items set forth in Section 5 of your Amended Employment Agreement (defined
therein, and referred to throughout this Letter Agreement, as “Confidential Information”), a copy of which is attached
to this Letter Agreement as Attachment A for your convenience. This prohibition is subject to and limited by your Retained Rights
in Paragraph 16 below.

 

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10.         Return
of Company Property. Regardless of whether you sign this Letter Agreement, in accordance with your Amended Employment Agreement
and as a condition of receiving the Severance Benefits set forth in Paragraph 2 and Paragraph 3 above, you must return to the Company
any and all office equipment, documents, files, materials, electronic information, records, computer discs, equipment or other
items in your possession or control belonging to the Company or containing any Confidential Information relating to the Company
(except as may be necessary in your continued duties and responsibilities as a director of the Company), and you represent and
agree that you have done so.

 

Post-Termination
Restrictions 

 

11.         Regardless
of whether you sign this Letter Agreement, you remain legally bound by, and must comply with, the terms, conditions and restrictions
of Section 7 (Non-Competition) of the Amended Employment Agreement, including, but not limited to, the non-solicitation and other
provisions set forth in Section 7(c) of the Amended Employment Agreement. The twelve (12) month Post Employment Non-Compete Period
(as defined in the Amended Employment Agreement) will be extended by any period of time in which you are in violation of such Section
7.

 

12.         In
the event you violate any of the restrictions referenced in Paragraph 11 above, the Company shall have the right, in its sole discretion,
to cease making any payments to you which otherwise may be required pursuant to Paragraphs 2 and/or 3 above; however, this shall
not affect the validity or enforceability of the covenants referenced in Paragraph 11 above and your Amended Employment Agreement,
which shall remain in full force and effect.

 

Defamatory Remarks
and Publications

 

13.         You
agree that you will not make any defamatory comments or remarks, as defined by law, in writing, orally or electronically, about
the Company or any other Released Party (as defined in Paragraph 14 below) and their respective products and services. You further
agree that you will not make, or cause to be made, any references whatsoever to any of the Released Parties, or to any fictitious
person or entity intended to resemble any of the Released Parties, in any book, article, letter or any other form of publication
or writing that you author or that you assist a third-party in authoring for publication or any other form of public dissemination,
provided that this prohibition does not include your stating or confirming that you have been employed by the Company for your
period of employment and stating your titles, roles and responsibilities. These restrictions are subject to and limited by your
Retained Rights in Paragraph 16 below.

 

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General Release

 

14(a).         By
Executive. You, for yourself, your heirs, assigns, successors, executors, and administrators (hereinafter collectively referred
to as the “Releasor”), in consideration of the promises and covenants set forth herein, hereby fully release and discharge,
to the maximum extent permitted by law, the Company and its parent, subsidiaries, affiliates, officers, directors, members, shareholders,
successors, partners, principals, employees, agents, representatives, fiduciaries, attorneys, and/or anyone else connected with
each of the foregoing (collectively, the “Released Parties”), forever and unconditionally from any and all manner
of action, claim, demand, damages, cause of action, debt, sum of money, contract, covenant, controversy, agreement, promise, judgment,
and demand whatsoever, in law or equity, known or unknown, existing or claimed to exist (hereinafter, collectively referred to
as “Claims”) arising from the beginning of time through the execution of this Letter Agreement, including without
limitation, all Claims relating to or arising out of your employment and/or termination of employment with the Company, including
any Claims under your Amended Employment Agreement, bonus and/or employee benefits and/or any discrimination claim based on race,
religion, color, national origin, age, sex, sexual orientation or preference, disability, retaliation, or any cause of action under
the following in each case as amended: the Age Discrimination in Employment Act of 1967, Title VII of the Civil Rights Act of 1964,
the Civil Rights Act of 1991, the Civil Rights Act of 1866, the Equal Pay Act of 1963, the Americans with Disabilities Act of 1990,
the Family and Medical Leave Act of 1993, the Worker Adjustment and Retraining Notification Act, the Employee Retirement Income
Security Act of 1974 (except any valid claim to recover vested benefits, if applicable), the Sarbanes-Oxley Act of 2002, any applicable
Executive Order program, and their state or local counterparts, including without limitation, applicable state statutes, including
state anti-discrimination statutes and regulations, such as the Massachusetts Fair Employment Practices Act, the Massachusetts
Civil Rights Act, the Massachusetts Equal Rights Law, the Massachusetts Wage Act, the Massachusetts Small Necessities Leave Act,
the Massachusetts Earned Sick Time Law, and the Massachusetts Parental Leave Law, and/or any other federal, state or local law,
rule, regulation, constitution or ordinance, or under any public policy or common law or arising under any practices or procedure
of the Company, and/or any claim for wrongful termination, back pay, future wage loss, any other claim, whether in tort, contract
or otherwise, or any claim for costs, fees or other expenses, including attorneys’ fees.

 

(b).       By Company.
The Company and its officers, directors, successors, principals, representatives, fiduciaries, attorneys, and/or anyone else connected
with each of the foregoing in consideration of the promises and covenants set forth herein, hereby fully release and discharge
you and your representatives, fiduciaries, attorneys, from any and all manner of action, claim, demand, damages, cause of action,
debt, sum of money, contract, covenant, controversy, agreement, promise, judgment, and demand whatsoever, in law or equity, known
or unknown, existing or claimed to exist (hereinafter, collectively referred to as “Claims”) arising from the
beginning of time through the execution of this Letter Agreement, including without limitation, all Claims relating to or arising
out of your employment and/or termination of employment with the Company, including without limitation, applicable state statutes,
including federal, state or local law, rule, regulation, constitution or ordinance, or under any public policy or common law, or
any claim for costs, fees or other expenses, including attorneys’ fees.

 

(c).       Known
and Unknown Claims. Please note also that this General Release includes all Claims known or unknown by you, those that you
may have already asserted or raised as well as those that you have never asserted or raised.

 

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Non-Released Claims.

 

15.         The
General Release in Paragraph 14 above does not apply to:

 

(a)          Any
Claims for vested benefits under any Company retirement, 401(k), profit-sharing or other deferred compensation plan;

 

(b)          Any
Claims to require the Company or you to honor its or your commitments set forth in this Letter Agreement;

 

(c)          Any
Claims to interpret or to determine the scope, meaning, enforceability or effect of this Letter Agreement;

 

(d)          Any
Claims that arise after you have signed this Letter Agreement;

 

(e)          Any
Claims for worker’s compensation benefits, any Claims for unemployment compensation benefits, and any other Claims that cannot
be waived by a private agreement.

 

The General Release
is subject to and restricted by your Retained Rights in Paragraph 16 below.

 

Retained Rights.

 

16(a).         Regardless
of whether or not you sign this Agreement, nothing in this Agreement is intended to or shall be interpreted: (i) to restrict or
otherwise interfere with your obligation to testify truthfully in any forum; (ii) to restrict or otherwise interfere with your
right and/or obligation to contact, cooperate with, provide information to, or testify or otherwise participate in, any action,
investigation or proceeding of any government agency or commission (including, but not limited, to the Equal Employment Opportunity
Commission (“EEOC”)); or (iii) to disclose any information or produce any documents as is required by law or legal
process.

 

(b).         Further,
the General Release in Paragraph 14 does not prevent you from contacting or filing a charge with any federal, state or local government
agency or commission (including, but not limited to, the EEOC). However, the General Release does prevent you, to the maximum extent
permitted by law, from obtaining any monetary or other personal relief for any of the Claims you have released in Paragraph 14
with regard to any charge you may file or which may be filed on your behalf.

 

Representations.

 

17.         By
signing this Letter Agreement, you acknowledge that:

 

(i)        you have read
and fully understand the terms of this Letter Agreement, including the General Release;

 

(ii)        you have been
advised in writing by the Company and urged to consult with your attorneys prior to signing this Letter Agreement concerning the
terms of this Letter Agreement, including the General Release;

 

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(iii)        you have
agreed to this Letter Agreement, including the General Release, knowingly and voluntarily and were not subjected to any undue influence
or coercion in agreeing to its terms;

 

(iv)        you have been
given at least 21 days to consider this Letter Agreement, and acknowledge that in the event that you execute this Letter Agreement
prior to the expiration of the 21 day period, you hereby waive the balance of said period;

 

(v)        you will have
seven (7) days following your execution of this Letter Agreement to revoke this Letter Agreement and this Letter Agreement shall
not become effective or enforceable until the revocation period has expired. Any revocation within this seven day period must be
submitted in writing and personally delivered, or mailed by 5:30 p.m. on the 7th day following your execution of this
Letter Agreement to the undersigned at 200 Cambridge Park Drive, Suite 2000, Cambridge, MA 02140. No payment provided for in Section
2 of this Letter Agreement will be made until after the seven (7) day period has expired and this Letter Agreement has become effective.
If the Letter Agreement is revoked by you then you shall forfeit the payment and benefits provided in this Letter Agreement and
the Company shall not be required to provide any such payment, benefits or other consideration;

 

(vi)        you
agree that, by signing this Letter Agreement, you will be receiving consideration in excess of that to which you are entitled absent
providing the Release contained herein; and

 

(vii)        you have
agreed that no provision of this Letter Agreement may be modified, changed, waived or discharged unless such waiver, modification,
change or discharge is agreed to in writing and signed by the Company.

 

(viii)      you
agree that no promise or inducement not expressed in this Letter Agreement has been made to you;

 

(ix)         You
understand that you are waiving your Claims as set forth in Paragraph 14(a) above, including, but not limited to, Claims for age
discrimination under the Age Discrimination in Employment Act (subject to the limitations in Paragraph 15 above and your Retained
Rights in Paragraph 16 above); and

 

(x)          You
have adequate information to make a knowing and voluntary waiver of any and all Claims as set forth in Paragraph 14(a) above.

 

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Future Cooperation

 

18.         You
agree to cooperate with any reasonable request by the Company in connection with any matter with which you were involved or any
existing or potential claim, investigation, administrative proceeding, lawsuit or other legal or business matter that arose during
your employment by the Company. You agree that after the Separation Date, you will make yourself available, upon reasonable notice
and under reasonable conditions (including in your continued capacity as a member of the Company’s board of directors), to
respond to inquiries and requests for information and assist the Company in any capacity with respect to matters of which you were
involved or had knowledge as a result of your employment with the Company. You further agree to provide reasonable assistance to
the Company and its respective representatives in defense of any claims that have been or may be made against the Company or any
Released Party, and will assist the Company in the prosecution of any claims that have been or may be made by the Company or Released
Party, to the extent that such claims may relate to the period of your employment with the Company. You agree to promptly notify
the Company’s General Counsel in the manner described in Paragraph 19 below if you become aware of any lawsuits involving
such claims that may be filed or threatened against the Company or any Released Party. You also agree to promptly inform the General
Counsel (to the extent that you are legally permitted to do so) in the manner described in Paragraph 19, if you are requested to
provide testimony or documents protected from disclosure under this Letter Agreement, or if you are asked to assist in any investigation
of the Company or any Released Party (or their actions), regardless of whether a lawsuit or other proceeding has then been filed
against the Company or Released Party with respect to such investigation. Upon presentation of appropriate documentation, the Company
shall pay or reimburse you for all reasonable out-of-pocket travel, duplicating or telephonic expenses incurred by you in complying
with this Paragraph 18. Nothing in this Paragraph 18 shall be construed to prohibit you from exercising your Retained Rights as
specified in Paragraph 16 above.

 

Duty to Notify.

 

19.         Regardless
of whether you sign this Letter Agreement, in the event you receive a request or demand, orally, in writing, electronically or
otherwise, for the disclosure or production of Confidential Information which you created or acquired in the course of your employment
(as defined in your Employment Agreement, you must notify immediately the Company’s General Counsel by calling him at the
Company’s offices. Regardless of whether you are successful in reaching him by telephone, you also must notify him immediately
in writing, via certified mail, at the Company’s offices at 200 CambridgePark Drive, Suite 2000, Cambridge, MA 02140. A copy
of the request or demand as well as any and all documents potentially responsive to the request or demand shall be included with
the written notification. You agree to wait a minimum of ten (10) days (or the maximum time permitted by such legal process, if
less) after sending the letter before making a disclosure or production to give the Company time to determine whether the disclosure
or production involves Confidential Information, in which event the Company may seek to prohibit and/or restrict the production
and/or disclosure and/or to obtain a protective order with regard thereto. This obligation shall not apply in the event of requests
or demands for Confidential Information from the government (federal, state or local).

 

Breach

 

20.         You
acknowledge that any breach by you of any of the terms of this Letter Agreement, shall immediately relieve and excuse the Company
from its obligations under this Letter Agreement, and the Company shall have the right to seek any other legal or equitable relief
that may be available.

 

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Entire Agreement,
Amendment and Waiver

 

21.         You
understand that this Letter Agreement fully and completely waives and gives up all claims you may have against the Company that
are waivable under applicable law, excepting only claims to enforce this Letter Agreement.

 

22.         This
Letter Agreement, and the applicable plans and agreements governing equity awards to you, contain the entire understanding between
you and the Company, and supersede any and all other prior agreements, understandings, discussions, negotiations whether written
or oral between you and the Company, including, without limitation, the Amended Employment Agreement, with the exception of the
Disclosure of Information, Developments, Non-Competition and Return of Information provisions contained in Sections 5, 6, 7 and
8 therein, the tax provisions in Sections 11(d), 11(e), and 11(f), and the Notices, Enforcement and Remedies provisions of Sections
12, 13(h) and 13(i), which provisions shall be interpreted to provide the Company with cumulative rights, remedies, and protections
and shall be given full force and effect. You acknowledge that neither the Company nor any representative of the Company has made
any representation or promise to you other than set forth herein.

 

23.         This
Letter Agreement shall be binding upon the parties and may not be modified in any manner, except by an instrument in writing of
concurrent or subsequent date signed by duly authorized representatives of the parties hereto. This Letter Agreement is binding
upon and shall inure to the benefit of the parties and their respective agents, assigns, heirs, executors, successors and administrators.
No delay or omission by the Company in exercising any right under this Letter Agreement shall operate as a waiver of that or any
other right. A waiver or consent given by the Company on any one occasion shall be effective only in that instance and shall not
be construed as a bar to or waiver of any right on any other occasion.

 

Governing Law

 

24.         This
Letter Agreement shall be governed by the laws of the Commonwealth of Massachusetts, excluding conflicts of law principles.

 

Waiver of Jury Trial

 

25.         The
parties hereby knowingly, voluntarily, and intentionally waive the right any of them have to a trial by jury of, under or in connection
with this Letter Agreement or any agreement or document executed in conjunction therewith or any course of conduct, statements
(whether verbal or written) or actions of any party relating hereto or thereto.

 

Interpretation of
this Letter Agreement/Severability

 

26.         Nothing
in this Letter Agreement is intended to violate any law or shall be interpreted to violate any law. If any paragraph or part or
subpart of any paragraph in this Letter Agreement or the application thereof is construed to be overbroad and/or unenforceable,
then the court making such determination shall have the authority to narrow the paragraph or part or subpart of the paragraph as
necessary to make it enforceable and the paragraph or part or subpart of the paragraph shall then be enforceable in its/their narrowed
form. Moreover, each paragraph or part or subpart of each paragraph in this Letter Agreement is independent of and severable (separate)
from each other. In the event that any paragraph or part or subpart of any paragraph in this Letter Agreement is determined to
be legally invalid or unenforceable by a court and is not modified by a court to be enforceable, the affected paragraph or part
or subpart of such paragraph shall be stricken from the Letter Agreement, and the remaining paragraphs or parts or subparts of
such paragraphs of this Agreement shall remain in full, force and effect.

 

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No Admissions

 

27.         It
is understood and agreed that this Letter Agreement does not constitute an admission by the Company or you that any action either
party has taken was unlawful or wrongful, or that any action constituted a breach of contract or violated any federal, state, or
local law, policy, rule or regulation.

 

    	Page 10 of 11 

     

    

 

If the terms of this
Letter Agreement are acceptable to you, please sign and date the enclosed copies of this Letter Agreement and return both to the
undersigned. A fully executed copy will be returned to you.         

 

	 	Sincerely,
	 	 
	 	ENUMERAL BIOMEDICAL HOLDINGS, INC.
	 	 	 
	 	By:	/s/ Matthew A. Ebert
	 	Name:  	Matthew A. Ebert
	 	Title:	General Counsel

 

	ACCEPTED AND AGREED:	 
	 	 
	/s/ Arthur H. Tinkelenberg, Ph.D.	 
	Arthur H. Tinkelenberg, Ph.D.	 
	 	 
	Dated:	4 August 2016	 

 

    	Page 11 of 11

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