Document:

Exhibit 10.1

 

NOTE PURCHASE AGREEMENT

 

NOTE PURCHASE AGREEMENT (this “Agreement”)
made as of the last date set forth on the signature page hereof between Protea Biosciences Group, Inc. (the “Company”),
and the undersigned (the “Lender”).

 

WITNESSETH:

 

WHEREAS, the Company
desires to borrower the sum of $650,000 from the Lender and the Lender is willing to make a $650,000 loan to the Company (the “Loan”),
to be evidenced by a 10% original issue discount secured promissory note in $720,000 principal face amount due October 15, 2016
(the “Note”);

 

NOW, THEREFORE, in consideration
of the premises and the mutual representations and covenants hereinafter set forth, the parties hereto do hereby agree as follows:

 

		I.	SUBSCRIPTION FOR SECURITIES AND REPRESENTATIONS BY LENDER

 

1.1       Subject
to the terms and conditions hereinafter set forth, the Lender hereby subscribes for and agrees to purchase from the Company, and
the Company agrees to issue and deliver to the Lender, the Note for the aggregate subscription price of $650,000.

 

1.2       100%
of the proceeds of the Loan shall be used to repay a $655,000 face amount note issued by the Company to St. George Investments
LLC that is due and payable on September 4, 2016 (the “St. George Note”). Accordingly, the proceeds of the Loan shall
be payable by wire transfer, to the Company in accordance with the wire instructions below, and shall be applied by the Company
toward the payment in full of the St. George Note.

 

Company Wire Instructions:

BANK: United Bank, Inc.

514 Market Street

Parkersburg, WV 26101

ABA#: 051900395

BENEFICIARY: Protea Biosciences, Inc.

ACCOUNT: 0010397647

 

1.3       The
Lender recognizes that the purchase of the Note involves a high degree of risk including, but not limited to, the following: (a)
the Company has a limited operating history and requires substantial funds in addition to the proceeds of the Note; (b) an investment
in the Company is highly speculative, and only investors who can afford the loss of their entire investment should consider investing
in the Company and the Note; (c) the Lender may not be able to liquidate its investment; (d) transferability of the Note is extremely
limited; (e) in the event of a disposition, the Lender could sustain the loss of its entire investment; (f) the Company has not
paid any dividends since its inception and does not anticipate paying any dividends; and (g) the other risks associated with the
Company’s business, financial situation and the Note set forth in the Company’s Form 10-K Annual Report on Form 10-K
for the fiscal year ended December 31, 2015 and other periodic reports filed by the Company with the Securities and Exchange Commission
under the Securities Exchange Act of 1934, as amended (the “SEC Reports”).

 

    	 	 	 

     

    

 

1.4       At
the time such Lender was offered the Note, it was, and as of the date hereof it is, an “accredited investor” as defined
in Rule 501(a) under the Securities Act, as indicated by the Lender’s responses to the questions contained in Article VII
hereof, and that the Lender is able to bear the economic risk of an investment in the Note.

 

1.5       The
Lender hereby acknowledges and represents that (a) the Lender has knowledge and experience in business and financial matters, prior
investment experience, including investment in securities that are non-listed, unregistered and/or not traded on a national securities
exchange or the Lender has employed the services of a “purchaser representative” (as defined in Rule 501 of Regulation
D), attorney and/or accountant to read all of the documents furnished or made available by the Company both to the Lender and to
all other prospective investors in the Note to evaluate the merits and risks of such an investment on the Lender’s behalf;
(b) the Lender recognizes the highly speculative nature of this investment; and (c) the Lender is able to bear the economic risk
that the Lender hereby assumes.

 

1.6       The
Lender hereby acknowledges receipt of, and has an opportunity to review, this Agreement, and the form of Note annexed as Exhibit
A, hereto, the form of Guaranty Agreement of Protea Biosciences, Inc. (the “Subsidiary”) annexed as Exhibit
B hereto, and the form of Security Agreement annexed as Exhibit C hereto all other SEC Reports, including the Company’s
Annual Report on Form 10-K for the year ended 2015 and its Quarterly Report on Form 10-Q for the fiscal quarter ended June 30,
2016 (collectively referred to as the “Transaction Documents”), and has received any additional information that the
Lender has requested from the Company, and has been afforded the opportunity to ask questions of and receive answers from duly
authorized officers or other representatives of the Company concerning the Company and the terms and conditions of the Note; provided,
however that no investigation performed by or on behalf of the Lender shall limit or otherwise affect its right to rely on the
representations and warranties of the Company contained herein, except to the extent that the Lender had actual knowledge at the
time of Closing that any such representation or warranty was untrue.

 

1.7(a)In
making the decision to invest in the Note, the Lender has relied solely upon the information provided by the Company in the Transaction
Documents. To the extent necessary, the Lender has retained, at its own expense, and relied upon appropriate professional advice
regarding the investment, tax and legal merits and consequences of this Agreement and the purchase of the Note hereunder. The Lender
disclaims reliance on any statements made or information provided by any person or entity in the course of Lender’s consideration
of an investment in the Note other than the Transaction Documents.

 

(b)       The
Lender represents that the Lender did not learn of the offering of the Note by means of any form of general solicitation or general
advertising, and in connection therewith, the Lender did not (i) receive or review any advertisement, article, notice or other
communication published in a newspaper or magazine or similar media or broadcast over television or radio, whether closed circuit,
or generally available; or (ii) attend any seminar meeting or industry investor conference whose attendees were invited by any
general solicitation or general advertising.

 

1.8       The
Lender hereby acknowledges that the Note has not been reviewed by the SEC nor any state regulatory authority since the Note are
intended to be exempt from the registration requirements of Section 5 of the Securities Act, pursuant to Regulation D. The Lender
understands that the securities underlying theNote have not been registered under the Securities Act or under any state Note or
“blue sky” laws and agrees not to sell, pledge, assign or otherwise transfer or dispose of the Note unless they are
registered under the Securities Act and under any applicable state securities or “blue sky” laws or unless an exemption
from such registration is available.

 

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1.9       The
Lender understands that the securities underlying the Note have not been registered under the Securities Act by reason of a claimed
exemption under the provisions of the Securities Act that depends, in part, upon the Lender’s investment intention and investment
qualification. In this connection, the Lender hereby represents that the Lender is purchasing the Note for the Lender’s own
account for investment and not with a view toward the resale or distribution to others; provided, however, that nothing contained
herein shall constitute an agreement by the Lender to hold the Note for any particular length of time and the Company acknowledges
that the Lender shall at all times retain the right to dispose of its property as it may determine in its sole discretion, subject
to any restrictions imposed by applicable law. The Lender, if an entity, further represents that it was not formed for the purpose
of purchasing the Note.

 

1.10       The
Lender consents to the placement of a legend on any certificate or other document evidencing the Note that such Note has not been
registered under the Securities Act or any state Note or “blue sky” laws and setting forth or referring to the restrictions
on transferability and sale thereof contained in this Agreement. The Lender is aware that the Company will make a notation in its
appropriate records with respect to the restrictions on the transferability of such Note.

 

1.11       The
Lender hereby represents that the address of the Lender furnished by Lender on the signature page hereof is the Lender’s
principal residence if Lender is an individual or its principal business address if it is a corporation or other entity.

 

1.12       Such
Lender understands that the securities are “restricted securities” and have not been registered under the Securities
Act or any applicable state Note law and is acquiring the Note as principal for its own account and not with a view to or for distributing
or reselling such Note or any part thereof in violation of the Securities Act or any applicable state securities law, has no present
intention of distributing any of such Note in violation of the Securities Act or any applicable state Note law and has no direct
or indirect arrangement or understandings with any other persons to distribute or regarding the distribution of such Note in violation
of the Securities Act or any applicable state securities law. Furthermore, such Lender is not purchasing the Note as a result of
any advertisement, article, notice or other communication regarding the Note published in any newspaper, magazine or similar media
or broadcast over television or radio or presented at any seminar or any other general solicitation or general advertisement.

 

1.13       The
Lender represents that the Lender has full power and authority (corporate, statutory and otherwise) to execute and deliver this
Agreement and to purchase the Note. This Agreement constitutes the legal, valid and binding obligation of the Lender, enforceable
against the Lender in accordance with its terms.

 

1.14       If
the Lender is a corporation, partnership, limited liability company, trust, employee benefit plan, individual retirement account,
Keogh Plan, or other tax-exempt entity, it is authorized and qualified to invest in the Company and the person signing this Agreement
on behalf of such entity has been duly authorized by such entity to do so.

 

1.15       The
Lender acknowledges that he or it is not a Registered Representative of a Financial Industry Regulatory Authority (“FINRA”)
member firm.

 

1.16       The
Lender agrees not to issue any public statement with respect to the Lender’s investment or proposed investment in the Company
or the terms of any agreement or covenant between them and the Company without the Company’s prior written consent, except
such disclosures as may be required under applicable law or under any applicable order, rule or regulation.

 

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1.17       The
Lender acknowledges that the information contained in the Transaction Documents or otherwise made available to the Lender is confidential
and non-public and agrees that all such information shall be kept in confidence by the Lender and neither used by the Lender for
the Lender’s personal benefit (other than in connection with this subscription) nor disclosed to any third party for any
reason, notwithstanding that a Lender’s subscription may not be accepted by the Company; provided, however, that (a) the
Lender may disclose such information to its affiliates and advisors who may have a need for such information in connection with
providing advice to the Lender with respect to its investment in the Company so long as such affiliates and advisors have an obligation
of confidentiality, and (b) this obligation shall not apply to any such information that (i) is part of the public knowledge or
literature and readily accessible at the date hereof, (ii) becomes part of the public knowledge or literature and readily accessible
by publication (except as a result of a breach of this provision) or (iii) is received from third parties without an obligation
of confidentiality (except third parties who disclose such information in violation of any confidentiality agreements or obligations,
including, without limitation, any subscription or other similar agreement entered into with the Company).

 

 

		II.	REPRESENTATIONS BY AND COVENANTS OF THE COMPANY

 

The Company hereby represents
and warrants to the Lender that:

 

2.1       Organization,
Good Standing and Qualification. The Company is a corporation duly organized, validly existing and in good standing under the
laws of the State of Delaware and has full corporate power and authority to own and use its properties and its assets and conduct
its business as currently conducted. The only subsidiary of the Company is Protea Biosciences, Inc., a Delaware corporation (the
“Subsidiary”). Each of the Company and itis Subsidiary is an entity duly organized, validly existing and in good standing
under the laws of the jurisdiction of its incorporation with the requisite corporate power and authority to own and use its properties
and assets and to conduct its business as currently conducted. Neither the Company, nor its Subsidiary is in violation of any of
the provisions of their respective articles of incorporation, by-laws or other organizational or charter documents, including,
but not limited to the Charter Documents (as defined below). Each of the Company and its Subsidiary is duly qualified to conduct
business and is in good standing as a foreign corporation in each jurisdiction in which the nature of the business conducted or
property owned by it makes such qualification necessary, except where the failure to be so qualified or in good standing, as the
case may be, would not result in a direct and/or indirect (i) material adverse effect on the legality, validity or enforceability
of any of the Note and/or this Agreement, (ii) material adverse effect on the results of operations, assets, business, condition
(financial and other) or prospects of the Company and its Subsidiary, taken as a whole, or (iii) material adverse effect on the
Company’s ability to perform in any material respect on a timely basis its obligations under the Transaction Documents (any
of (i), (ii) or (iii), a “Material Adverse Effect”).

 

2.2       Capitalization
and Voting Rights. The authorized, issued and outstanding capital stock of the Company is as set forth in Transaction Documents
and all issued and outstanding shares of capital stock of the Company are validly issued, fully paid and nonassessable. Except
as set forth in Transaction Documents hereto, (i) there are no outstanding securities of the Company or its Subsidiary which contain
any preemptive, redemption or similar provisions, nor is any holder of securities of the Company or the Subsidiary entitled to
preemptive or similar rights arising out of any agreement or understanding with the Company or the Subsidiary by virtue of any
of the Transaction Documents, and there are no contracts, commitments, understandings or arrangements by which the Company or its
Subsidiary is or may become bound to redeem a security of the Company or its Subsidiary; (ii) neither the Company nor the Subsidiary
has any stock appreciation rights or "phantom stock" plans or agreements or any similar plan or agreement; and (iii)
except as set forth in Transaction Documents there are no outstanding options, warrants, agreements, convertible securities, preemptive
rights or other rights to subscribe for or to purchase or acquire, any shares of capital stock of the Company or the Subsidiary
or contracts, commitments, understandings, or arrangements by which the Company or the Subsidiary is or may become bound to issue
any shares of capital stock of the Company or the Subsidiary, or securities or rights convertible or exchangeable into shares of
capital stock of the Company or the Subsidiary. Except as set forth in Transaction Documents and as otherwise required by law,
there are no restrictions upon the voting or transfer of any of the shares of capital stock of the Company pursuant to the Company’s
Charter Documents (as defined below) or other governing documents or any agreement or other instruments to which the Company is
a party or by which the Company is bound. All of the issued and outstanding shares of capital stock of the Company are validly
issued, fully paid and nonassessable and the shares of capital stock of the Subsidiary are owned by the Company, free and clear
of any mortgages, pledges, liens, claims, charges, encumbrances or other restrictions (collectively, “Encumbrances”).
All of such outstanding capital stock has been issued in compliance with applicable federal and state securities laws. The issuance
and sale of the Note will not obligate the Company to issue shares of Common Stock or other securities to any other person (other
than the Lender) and except as set forth in Transaction Documents will not result in the adjustment of the exercise, conversion,
exchange or reset price of any outstanding security. The Company does not have outstanding stockholder purchase rights or “poison
pill” or any similar arrangement in effect giving any person the right to purchase any equity interest in the Company upon
the occurrence of certain events.

 

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2.3       Authorization;
Enforceability. The Company has all corporate right, power and authority to enter into, execute and deliver this Agreement
and each other agreement, document, instrument and certificate to be executed by the Company in connection with the consummation
of the transactions contemplated hereby, including, but not limited to Transaction Documents and to perform fully its obligations
hereunder and thereunder. All corporate action on the part of the Company, its directors and stockholders necessary for the (a)
authorization execution, delivery and performance of this Agreement and the Transaction Documents by the Company; and (b) authorization,
sale, issuance and delivery of the Note and the performance of the Company’s obligations under this Agreement and the Transaction
Documents has been taken. This Agreement and the Transaction Documents have been duly executed and delivered by the Company and
each constitutes a legal, valid and binding obligation of the Company, enforceable against the Company in accordance with its respective
terms, subject to laws of general application relating to bankruptcy, insolvency and the relief of debtors and rules of law governing
specific performance, injunctive relief or other equitable remedies, and to limitations of public policy. The Note is duly authorized
and, when issued and paid for in accordance with the applicable Transaction Documents, will be duly and validly issued, fully paid
and non-assessable, free and clear of all Encumbrances other than restrictions on transfer provided for in the Transaction Documents.
The Shares, when issued and paid for in accordance with the terms of the Transaction Documents, will be validly issued, fully paid
and non-assessable, free and clear of all Encumbrances imposed by the Company other than restrictions on transfer provided for
in the Transaction Documents. Except as set forth on Schedule 2.3 hereto, the issuance and sale of the Note contemplated
hereby will not give rise to any preemptive rights or rights of first refusal on behalf of any person other than the Lenders.

 

2.4       No
Conflict; Governmental Consents.

 

(a)       The
execution and delivery by the Company of this Agreement and the Transaction Documents, the issuance and sale of the Note and the
consummation of the other transactions contemplated hereby or thereby do not and will not (i) result in the violation of any law,
statute, rule, regulation, order, writ, injunction, judgment or decree of any court or governmental authority to or by which the
Company is bound including without limitation all foreign, federal, state and local laws applicable to its business and all such
laws that affect the environment, except in each case as could not have or reasonably be expected to result in a Material Adverse
Effect, (ii) conflict with or violate any provision of the Company’s Articles of Incorporation (the “Articles”),
as amended or the Bylaws, (and collectively with the Articles, the “Charter Documents”) of the Company, and (iii) conflict
with, or result in a material breach or violation of, any of the terms or provisions of, or constitute (with or without due notice
or lapse of time or both) a default or give to others any rights of termination, amendment, acceleration or cancellation (with
or without due notice, lapse of time or both) under any agreement, credit facility, lease, loan agreement, mortgage, security agreement,
trust indenture or other agreement or instrument to which the Company or the Subsidiary is a party or by which any of them is bound
or to which any of their respective properties or assets is subject, nor result in the creation or imposition of any Encumbrances
upon any of the properties or assets of the Company or the Subsidiary, except as provided in the Security Agreement.

 

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(b)       No
approval by the holders of Common Stock, or other equity securities of the Company is required to be obtained by the Company in
connection with the authorization, execution, delivery and performance of this Agreement and the other Transaction Documents or
in connection with the authorization, issue and sale of the Note, except as has been previously obtained.

 

(c)       No
consent, approval, authorization or other order of any governmental authority or any other person is required to be obtained by
the Company in connection with the authorization, execution, delivery and performance of this Agreement and the other Transaction
Documents or in connection with the authorization, issue and sale of the Note, except such post-sale filings as may be required
to be made with the SEC, FINRA and with any state or foreign blue sky or securities regulatory authority, all of which shall be
made when required.

 

2.5       Consents
of Third Parties. No vote, approval or consent of any holder of capital stock of the Company or any other third parties is
required or necessary to be obtained by the Company in connection with the authorization, execution, deliver and performance of
this Agreement and the other Transaction Documents or in connection with the authorization, issue and sale of the Note, except
as previously obtained, each of which is in full force and effect.

 

2.6       SEC
Reports; Financial Statements. The Company has (a) for the twenty-four (24) months preceding the filing of the Form 10-K (or
such shorter period as the Company was required by law to file such reports) (i) disclosed all material information required to
be publicly disclosed by it on Form 8-K, (ii) filed all reports on Form 10-Q and Form 10-K and (iii) filed all other reports (other
than any Form 8-K) required to be filed by it under the Securities Act and the Exchange Act, including pursuant to Section 13(a)
or 15(d) thereof, and (b) since the filing of the Form 10-K, the Company has filed all reports required to be filed by it under
the Securities Act and Exchange Act (the foregoing materials being collectively referred to herein as the "SEC Reports"
and, together with the Schedules to this Agreement (if any), the “Disclosure Materials”) on a timely basis or has timely
filed a valid extension of such time of filing and has filed any such SEC Reports prior to the expiration of any such extension.
As of their respective dates, the SEC Reports complied in all material respects with the requirements of the Exchange Act and the
rules and regulations of the SEC promulgated thereunder, and none of the SEC Reports, when filed, contained any untrue statement
of a material fact or omitted to state a material fact required to be stated therein or necessary in order to make the statements
therein, in light of the circumstances under which they were made, not misleading. The financial statements of the Company included
in the SEC Reports comply in all material respects with applicable accounting requirements and the rules and regulations of the
SEC with respect thereto as in effect at the time of filing. Such financial statements have been prepared in accordance with United
States generally accepted accounting principles (“GAAP”) applied on a consistent basis during the periods involved,
except as may be otherwise specified in such financial statements or the footnotes thereto, and fairly present in all material
respects the financial position of the Company and its consolidated Subsidiary as of and for the dates thereof and the results
of operations and cash flows for the periods then ended, subject, in the case of unaudited statements, to normal, immaterial, year-end
audit adjustments.

 

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2.7       Licenses.
The Company and its Subsidiary have sufficient licenses, permits and other governmental authorizations currently required for the
conduct of their respective businesses or ownership of properties and is in all material respects in compliance therewith.

 

2.8       Litigation.
The Company knows of no pending or threatened legal or governmental proceedings against the Company or the Subsidiary which could
materially adversely affect the business, property, financial condition or operations of the Company and its Subsidiary, taken
as a whole, or which materially and adversely questions the validity of this Agreement or the other Transaction Documents or the
right of the Company to enter into this Agreement and the other Transaction Documents, or to perform its obligations hereunder
and thereunder. Neither the Company nor the Subsidiary is a party or subject to the provisions of any order, writ, injunction,
judgment or decree of any court or government agency or instrumentality which could materially adversely affect the business, property,
financial condition or operations of the Company and its Subsidiary taken as a whole. There is no action, suit, proceeding or investigation
by the Company or the Subsidiary currently pending in any court or before any arbitrator or that the Company or the Subsidiary
intends to initiate. Neither the Company nor the Subsidiary, nor any director or officer thereof, is or since the filing of the
Form 10-K has been the subject of any action involving a claim of violation of or liability under federal or state securities laws
or a claim of breach of fiduciary duty. There has not been, and to the Company’s knowledge, there is not pending or contemplated,
any investigation by the SEC involving the Company or any current or former director or officer of the Company.

 

2.9       Compliance.
Neither the Company nor the Subsidiary: (i) is in default under or in violation of (and no event has occurred that has not been
waived that, with notice or lapse of time or both, would result in a default by the Company or the Subsidiary under), nor has the
Company or the Subsidiary received notice of a claim that it is in default under or that it is in violation of, any indenture,
loan or credit agreement or any other agreement or instrument to which it is a party or by which it or any of its properties is
bound (whether or not such default or violation has been waived), (ii) is in violation of any judgment, decree or order of any
court, arbitrator or other governmental authority or (iii) is or has been in violation of any statute, rule, ordinance or regulation
of any governmental authority, including without limitation all foreign, federal, state and local laws relating to taxes, environmental
protection, occupational health and safety, product quality and safety and employment and labor matters, except in each case as
could not have or reasonably be expected to result in a Material Adverse Effect.

 

2.10       Regulatory
Permits. The Company and the Subsidiary possess all certificates, authorizations and permits issued by the appropriate federal,
state, local or foreign regulatory authorities necessary to conduct their respective businesses, except where the failure to possess
such permits could not reasonably be expected to result in a Material Adverse Effect (“Material Permits”), and neither
the Company nor the Subsidiary has received any notice of proceedings relating to the revocation or modification of any Material
Permit.

 

2.11       Disclosure.
The information set forth in the Transaction Documents as of the date hereof and as of the date of each Closing contains no untrue
statement of a material fact nor omits to state a material fact necessary in order to make the statements contained therein, in
light of the circumstances under which they were made, not misleading.

 

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2.12       Investment
Company. The Company is not an “investment company” within the meaning of such term under the Investment Company
Act of 1940, as amended, and the rules and regulations of the SEC thereunder.

 

2.13       Brokers.
Except for Laidlaw & Company (UK) Ltd., who has acted as placement agent for the Company, neither the Company nor any of the
Company's officers, directors, employees or stockholders has employed or engaged any broker or finder in connection with the transactions
contemplated by this Agreement and no fee or other compensation is or will be due and owing to any broker, finder, underwriter,
placement agent or similar person in connection with the transactions contemplated by this Agreement. The Company is not party
to any agreement, arrangement or understanding whereby any person has an exclusive right to raise funds and/or place or purchase
any debt or equity securities for or on behalf of the Company.

 

2.14       Intellectual
Property; Employees.

 

(a)       The
Company owns or possesses sufficient legal rights to all patents, trademarks, service marks, trade names, copyrights, trade secrets,
licenses, information and other proprietary rights and processes necessary for its business as now conducted and as presently proposed
to be conducted, without any known infringement of the rights of others and which the failure to so have could have a Material
Adverse Effect (collectively, the “Intellectual Property Rights”). Except as disclosed on the SEC Reports, there are
no material outstanding options, licenses or agreements of any kind relating to the Intellectual Property Rights, nor is the Company
bound by or a party to any material options, licenses or agreements of any kind with respect to the patents, trademarks, service
marks, trade names, copyrights, trade secrets, licenses, information and other proprietary rights and processes of any other person
or entity other than such licenses or agreements arising from the purchase of “off the shelf” or standard products.
The Company has not received any written communications alleging that the Company has violated or, by conducting its business as
presently proposed to be conducted, would violate any Intellectual Property Rights of any other person or entity. The Company and
its Subsidiary have taken reasonable security measures to protect the secrecy, confidentiality and value of all of their intellectual
properties, except where failure to do so could not, individually or in the aggregate, reasonably be expected to have a Material
Adverse Effect

 

(b)       The
Company is not aware that any of its employees is obligated under any contract (including licenses, covenants or commitments of
any nature) or other agreement, or subject to any judgment, decree or order of any court or administrative agency, that would interfere
with their duties to the Company or that would conflict with the Company’s business as presently conducted.

 

(c)       Neither
the execution nor delivery of this Agreement, nor the carrying on of the Company’s business by the employees of the Company,
nor the conduct of the Company’s business as presently conducted, will, to the Company’s knowledge, conflict with or
result in a breach of the terms, conditions or provisions of, or constitute a default under, any contract, covenant or instrument
under which any employee is now obligated.

 

(d)       To
the Company’s knowledge, no employee of the Company, nor any consultant with whom the Company has contracted, is in violation
of any term of any employment contract, proprietary information agreement or any other agreement and to the Company’s knowledge
the continued employment by the Company of its present employees, and the performance of the Company’s contracts with its
independent contractors, will not result in any such violation. The Company has not received any written notice alleging that any
such violation has occurred. Except as set forth in the SEC Reports, no employee of the Company has been granted the right to continued
employment by the Company or to any compensation following termination of employment with the Company except for any of the same
which would not have a Material Adverse Effect on the business of the Company. The Company is not aware that any officer, key employee
or group of employees intends to terminate his, her or their employment with the Company, nor does the Company have a present intention
to terminate the employment of any officer, key employee or group of employees.

 

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2.15       Title
to Properties and Assets; Liens, Etc. The Company has good and marketable title to its properties and assets, including the
properties and assets reflected in the most recent balance sheet included in the Company’s financial statements, and good
title to its leasehold estates, in each case subject to no Encumbrances, other than (a) those resulting from taxes which have not
yet become delinquent; and (b) Encumbrances which do not materially detract from the value of the property subject thereto or materially
impair the operations of the Company; and (c) those that have otherwise arisen in the ordinary course of business, none of which
are material. Except as set forth in Schedule 2.16, the Company is in compliance with all material terms of each lease to
which it is a party or is otherwise bound.

 

2.16       Obligations
to Related Parties. Except as set forth in the SEC Reports, there are no obligations of the Company to officers, directors,
stockholders, or employees of the Company other than (a) for payment of salary or other compensation for services rendered, (b)
reimbursement for reasonable expenses incurred on behalf of the Company and (c) for other standard employee benefits made generally
available to all employees (including stock option agreements outstanding under any stock option plan approved by the Board of
Directors of the Company). Except as set forth in the SEC Reports, none of the officers or directors of the Company and, to the
Company’s knowledge, none of the employees of the Company is presently a party to any transaction with the Company or the
Subsidiary (other than as holders of stock options and/or warrants, and for services as employees, officers and directors), including
any contract, agreement or other arrangement providing for the furnishing of services to or by, providing for rental of real or
personal property to or from, or otherwise requiring payments to or from any officer, director or such employee or, to the Company’s
knowledge, any entity in which any officer, director, or any such employee has a substantial interest or is an officer, director,
trustee or partner.

 

2.17       Material
Changes. Except as set forth in the SEC Reports, since the date of the latest audited financial statements included within
the SEC Reports (i) there has been no event, occurrence or development that has had or that could reasonably be expected to result
in a Material Adverse Effect, (ii) the Company has not incurred any liabilities (contingent or otherwise) other than (A) trade
payables, accrued expenses and other liabilities incurred in the ordinary course of business consistent with past practice and
(B) liabilities not required to be reflected in the Company's financial statements pursuant to generally accepted accounting principles
or required to be disclosed in filings made with the SEC, (iii) the Company has not altered its method of accounting or the identity
of its auditors, (iv) the Company has not declared or made any dividend or distribution of cash or other property to its stockholders
or purchased, redeemed or made any agreements to purchase or redeem any shares of its capital stock, and (v) the Company has not
issued any equity securities to any officer, director or affiliate, except pursuant to existing Company stock option plans. The
Company does not have pending before the SEC any request for confidential treatment of information.

 

2.18       Sarbanes-Oxley.
The Company is in compliance with all effective requirements of the Sarbanes-Oxley Act of 2002, as amended, and the rules and regulations
thereunder, that are applicable to it, except where such noncompliance could not have or reasonably be expected to result in a
Material Adverse Effect.

 

    	 	 	9

     

    

 

2.19       No
General Solicitation. None of the Company, its Subsidiary, any of their affiliates, and any person acting on their behalf,
has engaged in any form of general solicitation or general advertising (within the meaning of Regulation D under the Securities
Act) in connection with the offer or sale of the Note.

 

2.20       Taxes.
The Company has filed all U.S. federal, state, local and foreign tax returns which are required to be filed by each of them and
all such returns are true and correct in all material respects. The Company has paid all taxes whether or not shown on such returns
or pursuant to any assessments received by any of them or by which any of them are obligated to withhold from amounts owing to
any employee, creditor or third party. The Company has properly accrued all taxes required to be accrued and/or paid, except where
the failure to accrue would not have a Material Adverse Effect. To the knowledge of the Company, none of the tax returns of the
Company is currently being audited by any state, local or federal authorities. The Company has not waived any statute of limitations
with respect to taxes or agreed to any extension of time with respect to any tax assessment or deficiency. The Company has set
aside on its books adequate provision for the payment of any unpaid taxes.

 

2.21       Listing
and Maintenance Requirements. The Common Stock is registered pursuant to Section 12(b) or 12(g) of the Exchange Act, and the
Company has taken no action designed to, or which to its knowledge is likely to have the effect of, terminating the registration
of the Common Stock under the Exchange Act nor has the Company received any notification that the SEC is contemplating terminating
such registration. The Company has not, in the 12 months preceding the date hereof, received notice from any trading market on
which the Common Stock is or has been listed or quoted to the effect that the Company is not in compliance with the listing or
maintenance requirements of such trading market. The Company is, and has no reason to believe that it will not in the foreseeable
future continue to be, in compliance with all such listing and maintenance requirements

 

2.22       Disclosure.
All disclosure furnished by or on behalf of the Company to the Lender in the Transaction Documents regarding the Company, its business
and the transactions contemplated hereby, including the Disclosure Schedules to this Agreement, is true and correct and does not
contain any untrue statement of a material fact or omit to state any material fact necessary in order to make the statements made
therein, in light of the circumstances under which they were made, not misleading.

 

2.23       Seniority.
Upon payment in full of the St. George Note, no other indebtedness or other claim against the Company is senior to the Note in
right of payment, whether with respect to interest or upon liquidation or dissolution, or otherwise, other than indebtedness secured
by purchase money security interests (which is senior only as to underlying assets covered thereby) and capital lease obligations
(which is senior only as to the property covered thereby).

 

2.24       Private
Placement. Assuming the accuracy of the Lenders’ representations and warranties set forth in Section 1, no registration
under the Securities Act is required for the offer and sale of the Note by the Company to the Lender as contemplated hereby.

 

		III.	COVENANTS OF THE COMPANY

 

3.1       Transfer
Restrictions.

 

(a)       The
securities may only be disposed of in compliance with state and federal securities laws. In connection with any transfer of securities
other than pursuant to an effective registration statement or Rule 144 promulgated under the Securities Act, to the Company or
to an affiliate of a Lender or in connection with, the Company may require the transferor thereof to provide to the Company an
opinion of counsel selected by the transferor and reasonably acceptable to the Company, the form and substance of which opinion
shall be reasonably satisfactory to the Company, to the effect that such transfer does not require registration of such transferred
securities under the Securities Act. As a condition of transfer, any such transferee shall agree in writing to be bound by the
terms of this Agreement, and shall have the rights of a Lender under this Agreement.

 

    	 	 	10

     

    

 

(b)       The
Lender agrees to the imprinting, so long as is required by this Section 5.1, of a legend on any of the securities substantially
in the following form:

 

THIS [SECURITIES][COMMON STOCK] HAS NOT
BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE NOTE COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM
REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED
OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM,
OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE WITH APPLICABLE STATE
SECURITIES LAWS AS EVIDENCED BY A LEGAL OPINION OF COUNSEL TO THE TRANSFEROR TO SUCH EFFECT, THE SUBSTANCE OF WHICH SHALL BE REASONABLY
ACCEPTABLE TO THE COMPANY. THIS SECURITY MAY BE PLEDGED IN CONNECTION WITH A BONA FIDE MARGIN ACCOUNT OR OTHER LOAN SECURED BY
SUCH SECURITIES.

 

(c)       The
Lender understands that prior to September 2, 2011, the Company was a “shell company” as defined in Rule 12b-2 under
the Securities Exchange Act of 1934, as amended, (the “Exchange Act”). Pursuant to Rule 144(i), securities issued by
a current or former shell company that otherwise meet the holding period and other requirements of Rule 144 nevertheless cannot
be sold in reliance on Rule 144 unless at the time of a proposed sale pursuant to Rule 144 the Company is subject to the reporting
requirements of Section 13 or 15(d) of the Exchange Act and has filed all reports and other materials required to be filed by Section
13 or 15(d) of the Exchange Act, as applicable, during the preceding 12 months (or for such shorter period that the issuer was
required to file such reports and materials), other than Form 8-K reports. As a result, the restrictive legends on certificates
for the securities cannot be removed except in connection with an actual sale meeting the foregoing requirements or pursuant to
an effective registration statement.

 

3.2       Replacement
of Securities. If any certificate or instrument evidencing any securities is mutilated, lost, stolen or destroyed, the Company
shall issue or cause to be issued in exchange and substitution for and upon cancellation thereof, or in lieu of and substitution
therefor, a new certificate or instrument, but only upon receipt of evidence reasonably satisfactory to the Company of such loss,
theft or destruction and customary and reasonable indemnity, if requested. The applicants for a new certificate or instrument under
such circumstances shall also pay any reasonable third-party costs associated with the issuance of such replacement securities.
If a replacement certificate or instrument evidencing any securitiesis requested due to a mutilation thereof, the Company may require
delivery of such mutilated certificate or instrument as a condition precedent to any issuance of a replacement.

 

3.3       Furnishing
of Information. Until the time that no Lender owns securities, the Company covenants to maintain the registration of the Common
Stock under Section 12(b) or 12(g) of the Exchange Act and to timely file (or obtain extensions in respect thereof and file within
the applicable grace period) all reports required to be filed by the Company after the date hereof pursuant to the Exchange Act.
As long as Lender owns securities, if the Company is not required to file reports pursuant to the Exchange Act, it will prepare
and furnish to Lender and make publicly available in accordance with Rule 144(c) such information as is required for the Lenders
to sell the securities under Rule 144. The Company further covenants that it will take such further action as any holder of securities
may reasonably request, to the extent required from time to time to enable such person to sell such securities without registration
under the Securities Act within the requirements of the exemption provided by Rule 144.

 

    	 	 	11

     

    

 

3.4       Securities
Laws; Publicity. Unless otherwise required by applicable law, the Company shall, by 8:30 a.m. (New York City time) on the fourth
trading day immediately following the first and last Closings hereunder, issue a Current Report on Form 8-K disclosing the material
terms of the transactions contemplated hereby and including the Transaction Documents as exhibits thereto to the extent required
by law. The Company shall not publicly disclose the name of Lender, or include the name of any Lender in any filing with the SEC
or any regulatory agency or trading market, without the prior written consent of Lender, except: (a) as required by federal securities
law in connection with the filing of final Transaction Documents (including signature pages thereto) with the SEC and (b) to the
extent such disclosure is required by law, in which case the Company shall provide the Lender with prior notice of such disclosure
permitted under this clause (b).

 

3.5       Form
D; Blue Sky Filings. The Company agrees to timely file a Form D with respect to the securities as required under Regulation
D promulgated under the Securities Act and to provide a copy thereof, promptly upon request of the Lender. The Company shall take
such action as the Company shall reasonably determine is necessary in order to obtain an exemption for, or to qualify the securities
for, sale to the Lender at the Closing under applicable securities or “Blue Sky” laws of the states of the United States,
and shall provide evidence of such actions promptly upon request of any Lender.

 

3.6       Indemnification. 

 

(a)       The
Company agrees to indemnify and hold harmless the Lender, its affiliates and their respective officers, directors, employees, agents
and controlling persons (collectively, the “Lender Indemnified Parties”) from and against any and all loss, liability,
damage or deficiency suffered or incurred by any Indemnified Party by reason of any misrepresentation or breach of warranty by
the Company or, after any applicable notice and/or cure periods, nonfulfillment of any covenant or agreement to be performed or
complied with by the Company, in each case contained in this Agreement or any of the other Transaction Documents; and will promptly
reimburse the Lender Indemnified Parties for all expenses (including reasonable fees and expenses of legal counsel) as incurred
in connection with the investigation of, preparation for or defense of any pending or threatened claim related to or arising in
any manner out of any of the foregoing, or any action or proceeding arising therefrom (collectively, “Proceedings”),
whether or not such Lender Indemnified Party is a formal party to any such Proceeding.

 

(b)       If
for any reason (other than a final non-appealable judgment finding any Lender Indemnified Party liable for losses, claims, damages,
liabilities or expenses for its gross negligence or willful misconduct) the foregoing indemnity is unavailable to an Lender Indemnified
Party or insufficient to hold an Lender Indemnified Party harmless, then the Company shall contribute to the amount paid or payable
by a Lender Indemnified Party as a result of such loss, claim, damage, liability or expense in such proportion as is appropriate
to reflect not only the relative benefits received by the Company on the one hand and the Lender on the other, but also the relative
fault of the Company or the Placement Agent, as applicable, on the one hand and the Lender on the other, as well as any relevant
equitable considerations.

 

    	 	 	12

     

    

 

(c)       Notwithstanding
the foregoing, the Company shall not be liable to indemnify any Lender Indemnified Parties under Section 3.7(a) or to contribute
to the amount paid or payable by all Lender Indemnified Parties under Section 3.7(b) in an amount under both such Sections that
in the aggregate exceeds the Lender’s aggregate purchase price tendered hereunder.

 

5.10       Non-Public
Information. Except with respect to the material terms and conditions of the transactions contemplated by the Transaction Documents,
the Company covenants and agrees that neither it, nor any other person acting on its behalf, will provide Lender or its agents
or counsel with any information that the Company believes constitutes material non-public information, unless prior thereto Lender
shall have executed a written agreement regarding the confidentiality and use of such information. The Company understands and
confirms that Lender shall be relying on the foregoing covenant in effecting transactions in securities of the Company.

 

5.11       Use
of Proceeds. The proceeds of the Loan shall be used only for the purposes set forth in Section 1.3 of this Agreement

 

		IV.	MISCELLANEOUS

 

4.1       Any
and all notices or other communications or deliveries required or permitted to be provided hereunder shall be in writing and shall
be deemed given and effective on the earliest of: (a) the date of transmission, if such notice or communication is delivered via
facsimile or by electronic communication at or prior to 5:30 p.m. (New York City time) on a day in which the New York Stock Exchange
is open for trading (a “Trading Day”), (b) the next Trading Day after the date of transmission, if such notice or communication
is delivered via facsimile or electronic communication on a day that is not a Trading Day or later than 5:30 p.m. (New York City
time) on any Trading Day, (c) the second (2nd) Trading Day following the date of mailing, if sent by U.S. nationally
recognized overnight courier service or (d) upon actual receipt by the party to whom such notice is required to be given. The address
for such notices and communications shall be addressed as follows:

 

if to the
Company, to it at:

Protea Biosciences Group, Inc.

1311 Pineview Drive, Suite 501

Morgantown, WV 26505

Attn: Stephen C. Turner, CEO

 

With a copy to (which shall not constitute notice):

 

CKR Law LLP

1330 Avenue of the Americas, 14th Floor

New York, NY 10019

Attn: Stephen A. Weiss, Esq.

 

 

if to the Lender, to the Lender’s
address indicated on the signature page of this Agreement.

 

    	 	 	13

     

    

 

With a copy to (which shall not constitute notice):

 

 

4.2       Except
as otherwise provided herein, this Agreement shall not be changed, modified or amended except by a writing signed by the parties
to be charged, and this Agreement may not be discharged except by performance in accordance with its terms or by a writing signed
by the party to be charged. No waiver of any default with respect to any provision, condition or requirement of this Agreement
shall be deemed to be a continuing waiver in the future or a waiver of any subsequent default or a waiver of any other provision,
condition or requirement hereof, nor shall any delay or omission of any party to exercise any right hereunder in any manner impair
the exercise of any such right.

 

4.3       This
Agreement shall be binding upon and inure to the benefit of the parties hereto and to their respective heirs, legal representatives,
successors and assigns. The Company may not assign this Agreement or any rights or obligations hereunder without the prior written
consent of Lender (other than by merger). Lender may assign any or all of its rights under this Agreement to any person to whom
Lender assigns or transfers any securities, provided that such transferee agrees in writing to be bound, with respect to the transferred
securities, by the provisions of the Transaction Documents

 

4.4       The
Transaction Documents, together with the exhibits and schedules thereto, contain the entire understanding of the parties with respect
to the subject matter hereof and supersede all prior agreements and understandings, oral or written, with respect to such matters,
which the parties acknowledge have been merged into such documents, exhibits and schedules.

 

4.5       Upon
the execution and delivery of this Agreement by the Lender and the Company, this Agreement shall become a binding obligation of
the Lender with respect to the purchase of the Note as herein provided, subject, however, to the right hereby reserved by the Company
to enter into the same agreements with other Lender and to reject any subscription, in whole or in part, provided the Company returns
to Lender any funds paid by Lender with respect to such rejected subscription or portion thereof, without interest or deduction.

 

4.6       All
questions concerning the construction, validity, enforcement and interpretation of the Transaction Documents shall be governed
by and construed and enforced in accordance with the internal laws of the State of New York, without regard to the principles of
conflicts of law thereof. Each party agrees that all legal proceedings concerning the interpretations, enforcement and defense
of the transactions contemplated by this Agreement and any other Transaction Documents (whether brought against a party hereto
or its respective affiliates, directors, officers, shareholders, employees or agents) shall be commenced exclusively in the state
and federal courts sitting in the City of New York. Each party hereby irrevocably submits to the exclusive jurisdiction of the
state and federal courts sitting in the City of New York, borough of Manhattan for the adjudication of any dispute hereunder or
in connection herewith or with any transaction contemplated hereby or discussed herein (including with respect to the enforcement
of any of the Transaction Documents), and hereby irrevocably waives, and agrees not to assert in any suit, action or proceeding,
any claim that it is not personally subject to the jurisdiction of any such court, that such suit, action or proceeding is improper
or is an inconvenient venue for such proceeding.

 

4.7       In
order to discourage frivolous claims the parties agree that unless a claimant in any proceeding arising out of this Agreement succeeds
in establishing his claim and recovering a judgment against another party (regardless of whether such claimant succeeds against
one of the other parties to the action), then the other party shall be entitled to recover from such claimant all of its/their
reasonable legal costs and expenses relating to such proceeding and/or incurred in preparation therefor.

 

    	 	 	14

     

    

 

4.8       The
holding of any provision of this Agreement to be invalid or unenforceable by a court of competent jurisdiction shall not affect
any other provision of this Agreement, which shall remain in full force and effect. If any provision of this Agreement shall be
declared by a court of competent jurisdiction to be invalid, illegal or incapable of being enforced in whole or in part, such provision
shall be interpreted so as to remain enforceable to the maximum extent permissible consistent with applicable law and the remaining
conditions and provisions or portions thereof shall nevertheless remain in full force and effect and enforceable to the extent
they are valid, legal and enforceable, and no provisions shall be deemed dependent upon any other covenant or provision unless
so expressed herein.

 

4.9       It
is agreed that a waiver by either party of a breach of any provision of this Agreement shall not operate, or be construed, as a
waiver of any subsequent breach by that same party.

 

4.10       The
Company agrees to execute and deliver all such further documents, agreements and instruments and take such other and further action
as may be necessary or appropriate to carry out the purposes and intent of this Agreement.

 

4.11       This
Agreement may be executed in two or more counterparts each of which shall be deemed an original, but all of which shall together
constitute one and the same instrument. In the event that any signature is delivered by facsimile transmission or by e-mail delivery
of a “.pdf” format data file, such signature shall create a valid and binding obligation of the party executing (or
on whose behalf such signature is executed) with the same force and effect as if such facsimile or “.pdf” signature
page were an original thereof.

 

4.12       Nothing
in this Agreement shall create or be deemed to create any rights in any person or entity not a party to this Agreement.

 

4.13       In
addition to being entitled to exercise all rights provided herein or granted by law, including recovery of damages, the Lender
and the Company will be entitled to specific performance under this Agreement. The parties agree that monetary damages may not
be adequate compensation for any loss incurred by reason of any breach of obligations described in the foregoing sentence and hereby
agrees to waive in any action for specific performance of any such obligation the defense that a remedy at law would be adequate.

 

Balance of this page intentionally
left blank – signature page follows

 

 

 

    	 	 	15

     

    

 

IN WITNESS WHEREOF,
this Agreement has been duly executed by the Parties on the date and year first above written.

 

 

COMPANY:

 

 

PROTEA BIOSCIENCES GROUP, INC.

 

 

 

By:________________________________

Name: Stephen Turner

Title:   President

 

 

 

LENDER:

 

_____________________________________

 

 

 

By:_________________________________

Name:

Title:

 

 

    	 	 	1

     

    

 

FORM OF INVESTOR QUESTIONNAIRE

 

PROTEA BIOSCIENCES GROUP, INC.

 

For Individual Investors Only

 

 

(All individual investors must INITIAL
where appropriate. Where there are joint investors both parties must INITIAL):

 

	Initial _______	I certify that I have a “net worth” of at least $1 million either individually or through aggregating my individual holdings and those in which I have a joint, community property or other similar shared ownership interest with my spouse. For purposes of calculating net worth under this paragraph, (i) the primary residence shall not be included as an asset, (ii) to the extent that the indebtedness that is secured by the primary residence is in excess of the fair market value of the primary residence, the excess amount shall be included as a liability, and (iii) if the amount of outstanding indebtedness that is secured by the primary residence exceeds the amount outstanding 60 days prior to the execution of this Subscription Agreement, other than as a result of the acquisition of the primary residence, the amount of such excess shall be included as a liability.
	 	 
	Initial _______	I certify that I have had an annual gross income for the past two years of at least $200,000 (or $300,000 jointly with my spouse) and expect my income (or joint income, as appropriate) to reach the same level in the current year.

 

For Non-Individual
Investors

 

(all Non-Individual
Investors must INITIAL where appropriate):

 

	Initial _______	The undersigned certifies that it is a partnership, corporation, limited liability company or business trust that is 100% owned by persons who meet either of the criteria for Individual Investors, above.
	 	 
	Initial _______	The undersigned certifies that it is a partnership, corporation, limited liability company or business trust that has total assets of at least $5 million and was not formed for the purpose of investing in Company.
	 	 
	Initial _______	The undersigned certifies that it is an employee benefit plan whose investment decision is made by a plan fiduciary (as defined in ERISA §3(21)) that is a bank, savings and loan association, insurance company or registered investment adviser.
	 	 
	Initial _______	The undersigned certifies that it is an employee benefit plan whose total assets exceed $5,000,000 as of the date of the Subscription Agreement.
	 	 
	Initial _______	The undersigned certifies that it is a self-directed employee benefit plan whose investment decisions are made solely by persons who meet either of the criteria for Individual Investors, above.

 

 

    	 	A-1	 

     

    

 

	Initial _______	The undersigned certifies that it is a U.S. bank, U.S. savings and loan association or other similar U.S. institution acting in its individual or fiduciary capacity.
	 	 
	Initial _______	The undersigned certifies that it is a broker-dealer registered pursuant to §15 of the Securities Exchange Act of 1934.
	 	 
	Initial _______	The undersigned certifies that it is an organization described in §501(c)(3) of the Internal Revenue Code with total assets exceeding $5,000,000 and not formed for the specific purpose of investing in Company.
	 	 
	Initial _______	The undersigned certifies that it is a trust with total assets of at least $5,000,000, not formed for the specific purpose of investing in Company, and whose purchase is directed by a person with such knowledge and experience in financial and business matters that he is capable of evaluating the merits and risks of the prospective investment.
	 	 
	Initial _______	The undersigned certifies that it is a plan established and maintained by a state or its political subdivisions, or any agency or instrumentality thereof, for the benefit of its employees, and which has total assets in excess of $5,000,000.
	 	 
	Initial _______	The undersigned certifies that it is an insurance company as defined in §2(a)(13) of the Securities Act of 1933, as amended, or a registered investment company.

 

 

 

 

 

    	 	A-2	 

     

    

 

PROTEA BIOSCIENCES GROUP, INC.

Investor Questionnaire

(Must be completed by Purchaser)

 

Section A - Individual Purchaser Information

 

EXACT Purchaser Name(s) in which the Note is to be issued: ________________________________________________________________________

 

Individual executing Profile or Trustee: _______________________________________________________________________

 

Social Security Numbers / Federal I.D. Number: ________________________________________________________________________

 

Date of Birth: _________________ Marital Status: _________________

 

Joint Party Date of Birth:_________________

 

Investment Experience (Years): ___________

 

Annual Income: _________________

 

Net Worth: ________________

 

Home Street Address: ________________________________________________________________________

 

Home City, State & Zip Code: ________________________________________________________________________

 

Home Phone: ________________________ Home Fax: _____________________

 

Home Email: _______________________________

 

Employer: ________________________________________________________________________

 

Employer Street Address: ________________________________________________________________________

 

Employer City, State & Zip Code: ________________________________________________________________________

 

Bus. Phone: __________________________ Bus. Fax: _______________________

 

Bus. Email: ________________________________

 

Type of Business: ________________________________________________________________________

 

LAIDLAW Account Executive / Outside Broker/Dealer: _______________________________________________________

 

Please check if you are a FINRA member or affiliate of a FINRA
member firm: _______

 

 

    	 	A-3	 

     

    

 

Section B – Entity Purchaser Information

 

EXACT Purchaser Name(s) in which the Note is to be issued: ________________________________________________________________________

 

Authorized Individual executing Profile or Trustee: _______________________________________________________________________

 

Social Security Numbers / Federal I.D. Number: ________________________________________________________________________

 

Investment Experience (Years): ___________

 

Net Worth: ________________

 

Was the Trust formed for the specific purpose of purchasing
the Note?

 

[ ] Yes [ ] No

 

Principal Purpose (Trust)______________________________________

 

Type of Business: ________________________________________________________

 

Street Address: ________________________________________________________________________

 

City, State & Zip Code: ________________________________________________________________________

 

Phone: ________________________ Fax: ________________________

 

Email: __________________________

 

Laidlaw Account Executive / Outside Broker/Dealer:

 

_______________________________________________________

 

 

Please check if you are a FINRA member or affiliate of a FINRA
member firm: _______

 

    	 	A-4	 

     

    

 

FORWARD-LOOKING STATEMENTS

 

We have included in this Agreement, including
the Schedule, certain forward-looking statements. Such statements can be identified by the use of forward-looking terminology such
as “believe,” “expect,” “may,” “should,” “seek,” “on-track,”
“plan,” “project,” “forecast,” “intend” or “anticipate,” or the negative
thereof or comparable terminology, or by discussions of vision, strategy or outlook, including statements related to revenues and
profitability, pricing and competition, the continued viability of our technology, our growth and expansion plans, including retaining
new employees, compliance with governmental regulations, our intellectual property protection strategies, payment of dividends,
the volatility of our common stock and the market for our common stock, dilution, trading restrictions, use of proceeds and the
need for additional debt or equity funding. You are cautioned that our business and operations are subject to a variety of risks
and uncertainties, many of which are beyond our control and, consequently, our actual results may differ materially from those
projected by any forward-looking statements. See the section titled “Risk Factors” on Schedule 3A.9 and those described
under the heading “Risk Factors” contained in the Company’s Annual Report on Form 10-K filed with
the Commission on March 16, 2016, for information regarding certain important factors that could cause our actual results to differ
materially from those projected in our forward-looking statements. Our forward-looking statements contained herein speak only as
of the date of this Agreement. We make no commitment to revise or update any forward-looking statements in order to reflect events
or circumstances after the date any such statements are made. 

 

 

    	 	A-5Exhibit 10.2

 

THIS NOTE HAS NOT BEEN REGISTERED WITH
THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION
UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT
PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION
NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE WITH APPLICABLE STATE SECURITIES LAWS AS
EVIDENCED BY A LEGAL OPINION OF COUNSEL TO THE TRANSFEROR TO SUCH EFFECT, THE SUBSTANCE OF WHICH SHALL BE REASONABLY ACCEPTABLE
TO THE COMPANY. THIS NOTE MAY BE PLEDGED IN CONNECTION WITH A BONA FIDE MARGIN ACCOUNT OR OTHER LOAN SECURED BY THIS NOTE.

 

	Original Issue Date:	September 8, 2016
	Face Amount:	$720,000
	Purchase Price	$650,000

 

 

10% ORIGINAL ISSUE DISCOUNT SECURED PROMISSORY
NOTE

DUE OCTOBER 15, 2016

 

 

FOR VALUE RECEIVED,
of Protea Biosciences Group, Inc., a Delaware corporation, (the “Company”), having its principal place
of business at 1311 Pineview Drive, Suite 501, Morgantown, WV 26505, promises to pay to ______________________ (“_______)
or his or its registered assigns (together with _____________, the “Holder”), or shall have paid pursuant to
the terms hereunder, the principal sum of $720,000 (the “Face Amount”) on October 15, 2016 (the “Maturity
Date”), or such earlier date as this Note is required or permitted to be repaid, as provided hereunder, and to pay interest
to the Holder on the aggregate unconverted and then outstanding principal amount of this Note in accordance with the provisions
hereof. This Note is subject to the following additional provisions:

 

     Section 1.     Definitions.
For the purposes of this 10% original issue discount secured promissory note (the “Note”), in addition to the
terms defined elsewhere in this Note, (a) capitalized terms not otherwise defined herein shall have the meanings set forth in the
Subscription Agreement and (b) the following terms shall have the following meanings:

 

"Affiliate”
means any Person that, directly or indirectly through one or more intermediaries, controls or is controlled by or is under common
control with a Person, as such terms are used in and construed under Rule 405 under the Securities Act.

 

    	 	1	 

     

    

 

“Bankruptcy
Event” means any of the following events: (a) the Company or any Significant Subsidiary (as such term is defined in Rule
1-02(w) of Regulation S-X) thereof commences a case or other proceeding under any bankruptcy, reorganization, arrangement, adjustment
of debt, relief of debtors, dissolution, insolvency or liquidation or similar law of any jurisdiction relating to the Company or
any Significant Subsidiary thereof, (b) there is commenced against the Company or any Significant Subsidiary thereof any such case
or proceeding that is not dismissed within 60 days after commencement, (c) the Company or any Significant Subsidiary thereof is
adjudicated insolvent or bankrupt or any order of relief or other order approving any such case or proceeding is entered, (d) the
Company or any Significant Subsidiary thereof suffers any appointment of any custodian or the like for it or any substantial part
of its property that is not discharged or stayed within 60 calendar days after such appointment, (e) the Company or any Significant
Subsidiary thereof makes a general assignment for the benefit of creditors, (f) the Company or any Significant Subsidiary thereof
calls a meeting of its creditors with a view to arranging a composition, adjustment or restructuring of its debts or (g) the Company
or any Significant Subsidiary thereof, by any act or failure to act, expressly indicates its consent to, approval of or acquiescence
in any of the foregoing or takes any corporate or other action for the purpose of effecting any of the foregoing.

 

“Business
Day” means any day except any Saturday, any Sunday, any day which shall be a federal legal holiday in the United States
or any day on which banking institutions in the State of New York are authorized or required by law or other governmental action
to close.

 

“Change
of Control Transaction” means the occurrence after the date hereof of any of (a) an acquisition after the date hereof
by an individual or legal entity or “group” (as described in Rule 13d-5(b)(1) promulgated under the Exchange Act) of
effective control (whether through legal or beneficial ownership of capital stock of the Company, by contract or otherwise) of
in excess of 50% of the voting securities of the Company (other than by means of conversion or exercise of the Note and the Securities
issued together with the Note), (b) the Company merges into or consolidates with any other Person, or any Person merges into or
consolidates with the Company and, after giving effect to such transaction, the stockholder of the Company immediately prior to
such transaction own less than 50% of the aggregate voting power of the Company or the successor entity of such transaction, or
(c) the Company sells or transfers all or substantially all of its assets to another Person and the stockholder of the Company
immediately prior to such transaction own less than 50% of the aggregate voting power of the acquiring entity immediately after
the transaction, (d) a replacement at one time or within a three year period of more than one-half of the members of the Board
of Directors which is not approved by a majority of those individuals who are members of the Board of Directors on the date hereof
(or by those individuals who are serving as members of the Board of Directors on any date whose nomination to the Board of Directors
was approved by a majority of the members of the Board of Directors who are members on the date hereof), or (e) the execution by
the Company of an agreement to which the Company is a party or by which it is bound, providing for any of the events set forth
in clauses (a) through (d) above.

 

“Event
of Default” shall have the meaning set forth in Section 5(a).

 

"Interest
Rate" shall mean ten percent (10%) per annum.

 

    	 	2	 

     

    

 

“Guaranty
Agreement” means the guaranty agreement between the Holder and the Subsidiary referred to in Section 4(a).

 

“Liens”
means a lien, charge, security interest, encumbrance, right of first refusal, preemptive right or other restriction.

 

“New
York Courts” shall have the meaning set forth in Section 6(d).

 

“Original
Issue Date” means the date of the first issuance of the Note, regardless of any transfers of this Note and regardless
of the number of instruments which may be issued to evidence such Note.

 

“Person”
means an individual or corporation, partnership, trust, incorporated or unincorporated association, joint venture, limited liability
company, joint stock company, government (or an agency or subdivision thereof) or other entity of any kind.

 

“Subscription
Agreement” means the Subscription Agreement, dated as of September 2, 2016 among the Company and the Holder, as amended,
modified or supplemented from time to time in accordance with its terms.

 

“Subsidiary”
means Protea Biosciences, Inc., a Delaware corporation, and a wholly owned subsidiary of the Company.

 

“Security
Agreement” shall have the meaning set forth in Section 4(b).

 

“Transaction
Documents” shall mean collectively, the Subscription Agreement, the Security Agreement and this Note.

 

Section 2.     Payment. On
the Maturity Date, the Company shall pay to the Holder the $720,000 Face Amount of this Note plus simple interest on the then
unpaid principal Face Amount of this Note, at the Interest Rate, calculated, on the basis of a 360-day year consisting of twelve
30 calendar day periods, from the Original Issue Date to the date that the entire Face Amount of this Note is paid in full.

 

Section 3.     
Prepayment. The Company shall have the right at any time or from time to time to prepay all or any portion of the Face Amount
of this Note plus accrued interest herein at the Interest Rate, without any premium or penalty of any kind.

 

Section 4.     
Guaranty and Security.

 

     (a)     The Subsidiary
shall unconditionally and irrevocably guaranty to pay and perform all of the obligations of the Company under this Note pursuant
to the guaranty agreement in the form of Exhibit A annexed hereto and made a part hereof (the “Guaranty Agreement”).

 

    	 	3	 

     

    

 

     (b)     Payment
of this Note shall be secured by a first priority Lien and security interest on the accounts receivable and inventories of the
Company and all proceeds thereof in accordance with the security agreement, dated as of the Original Issue Date, between the Company
and its Subsidiaries, as debtors, and the Holder, as secured party, and in the form of Exhibit B annexed hereto and made
a part hereof (the “Security Agreement”).

 

     Section 5.     Events of Default.

 

(a)       “Event
of Default” means, wherever used herein, any of the following events (whatever the reason for such event and whether
such event shall be voluntary or involuntary or effected by operation of law or pursuant to any judgment, decree or order of any
court, or any order, rule or regulation of any administrative or governmental body):

 

(i)       any
default in the payment of the principal Face Amount of this Note or interest and other amounts owing to a Holder on this Note,
as and when the same shall become due and payable (whether on the Maturity Date or by acceleration or otherwise);

 

(ii)       the
Company shall fail to observe or perform any other covenant or agreement contained in this Note or other Transaction Documents,
which failure is not cured by the earlier of 10 Business Days or the Maturity Date;

 

(iii)       the
Company or any Significant Subsidiary (as such term is defined in Rule 1-02(w) of Regulation S-X) shall be subject to a Bankruptcy
Event;

 

(iv)       the
Company or any Subsidiary shall default on any of its obligations under any mortgage, credit agreement or other facility, indenture
agreement, factoring agreement or other instrument under which there may be issued, or by which there may be secured or evidenced,
any indebtedness for borrowed money or money due under any long term leasing or factoring arrangement that (a) involves an obligation
greater than $250,000, whether such indebtedness now exists or shall hereafter be created, and (b) results in such indebtedness
becoming or being declared due and payable prior to the date on which it would otherwise become due and payable;

 

(v)       the
Company shall be a party to any Change of Control Transaction or Sale of Control or shall agree to sell or dispose of all or in
excess of 40% of its assets in one transaction or a series of related transactions (whether or not such sale would constitute a
Change of Control Transaction);

 

(vi)       any
monetary judgment, writ or similar final process shall be entered or filed against the Company, any subsidiary or any of their
respective property or other assets for more than $250,000, and such judgment, writ or similar final process shall remain unvacated,
unbonded or unstayed for a period of 30 calendar days.

 

    	 	4	 

     

    

 

(b)       Remedies
Upon Event of Default. If any Event of Default occurs and shall be continuing, the outstanding principal Face Amount of this
Note, plus accrued but unpaid interest and the Interest Rate and other amounts owing in respect thereof through the date of acceleration,
shall become, at the Holder’s election, immediately due and payable in cash. The Company hereby waives, any presentment,
demand, protest or other notice of any kind, and the Holder may immediately and without expiration of any grace period enforce
any and all of its rights and remedies hereunder, including without limitation asserting all of its rights and remedies available
to it under the Security Agreement and applicable law. Such acceleration may be rescinded and annulled by Holder at any time prior
to payment hereunder and the Holder shall have all rights as a holder of the Note until such time, if any, as the Holder receives
full payment pursuant to this Section 5(b). No such rescission or annulment shall affect any subsequent Event of Default or impair
any right consequent thereon.

 

     Section 6.     Miscellaneous.

 

a)    
Notices. Any and all notices or other communications or deliveries to be provided by the Holder hereunder, including,
without limitation, any Notice of Conversion, shall be in writing and delivered personally, by facsimile, by electronic communication
or sent by a nationally recognized overnight courier service, addressed to the Company, at the address set forth above, or such
other facsimile number or address as the Company may specify for such purpose by notice to the Holder delivered in accordance with
this Section 6(a). Any and all notices or other communications or deliveries to be provided by the Company hereunder shall be in
writing and delivered personally, by facsimile, by electronic communication or sent by a nationally recognized overnight courier
service addressed to each Holder at the facsimile number or address of the Holder appearing on the books of the Company, or if
no such facsimile number or address appears, at the principal place of business of the Holder. Any notice or other communication
or deliveries hereunder shall be deemed given and effective on the earliest of (i) the date of transmission, if such notice or
communication is delivered via facsimile or electronic communication prior to 5:30 p.m. (New York City time), (ii) the date immediately
following the date of transmission, if such notice or communication is delivered via facsimile or electronic communication between
5:30 p.m. (New York City time) and 11:59 p.m. (New York City time) on any date, (iii) the second Business Day following the date
of mailing, if sent by nationally recognized overnight courier service or (iv) upon actual receipt by the party to whom such notice
is required to be given.

 

b)    
Absolute Obligation. Except as expressly provided herein, no provision of this Note shall alter or impair the obligation
of the Company, which is absolute and unconditional, to pay the principal of, liquidated damages and accrued interest, as applicable,
on this Note at the time, place, and rate, and in the coin or currency, herein prescribed. This Note is a direct debt obligation
of the Company. This Note ranks pari passu with all other Note now or hereafter issued under the terms set forth
herein.     

 

    	 	5	 

     

    

 

c)    
Lost or Mutilated Note. If this Note shall be mutilated, lost, stolen or destroyed, the Company shall execute and
deliver, in exchange and substitution for and upon cancellation of a mutilated Note, or in lieu of or in substitution for a lost,
stolen or destroyed Note, a new Note for the principal amount of this Note so mutilated, lost, stolen or destroyed, but only upon
receipt of evidence of such loss, theft or destruction of such Note, and of the ownership hereof, reasonably satisfactory to the
Company.

 

d)    
Governing Law. All questions concerning the construction, validity, enforcement and interpretation of this Note shall
be governed by and construed and enforced in accordance with the internal laws of the State of New York, without regard to the
principles of conflict of laws thereof. Each party agrees that all legal proceedings concerning the interpretation, enforcement
and defense of the transactions contemplated by any of the Transaction Documents (whether brought against a party hereto or its
respective Affiliates, directors, officers, shareholder, employees or agents) shall be commenced in the state and federal courts
sitting in the City of New York, Borough of Manhattan (the “New York Courts”). Each party hereto hereby irrevocably
submits to the exclusive jurisdiction of the New York Courts for the adjudication of any dispute hereunder or in connection herewith
or with any transaction contemplated hereby or discussed herein (including with respect to the enforcement of any of the Transaction
Documents), and hereby irrevocably waives, and agrees not to assert in any suit, action or proceeding, any claim that it is not
personally subject to the jurisdiction of such New York Courts, or such New York Courts are improper or inconvenient venue for
such proceeding. Each party hereby irrevocably waives personal service of process and consents to process being served in any such
suit, action or proceeding by mailing a copy thereof via registered or certified mail or overnight delivery (with evidence of delivery)
to such party at the address in effect for notices to it under this Note and agrees that such service shall constitute good and
sufficient service of process and notice thereof. Nothing contained herein shall be deemed to limit in any way any right to serve
process in any other manner permitted by applicable law. Each party hereto hereby irrevocably waives, to the fullest extent permitted
by applicable law, any and all right to trial by jury in any legal proceeding arising out of or relating to this Note or the transactions
contemplated hereby. If either party shall commence an action or proceeding to enforce any provisions of this Note, then the prevailing
party in such action or proceeding shall be reimbursed by the other party for its attorneys fees and other costs and expenses incurred
in the investigation, preparation and prosecution of such action or proceeding.

 

e)    
Waiver. Any waiver by the Company or the Holder of a breach of any provision of this Note shall not operate as or
be construed to be a waiver of any other breach of such provision or of any breach of any other provision of this Note. The failure
of the Company or the Holder to insist upon strict adherence to any term of this Note on one or more occasions shall not be considered
a waiver or deprive that party of the right thereafter to insist upon strict adherence to that term or any other term of this Note.
Any waiver by the Company or the Holder must be in writing.

 

    	 	6	 

     

    

 

f)     
Severability. If any provision of this Note is invalid, illegal or unenforceable, the balance of this Note shall
remain in effect, and if any provision is inapplicable to any Person or circumstance, it shall nevertheless remain applicable to
all other Persons and circumstances. If it shall be found that any interest or other amount deemed interest due hereunder violates
the applicable law governing usury, the applicable rate of interest due hereunder shall automatically be lowered to equal the maximum
rate of interest permitted under applicable law. The Company covenants (to the extent that it may lawfully do so) that it shall
not at any time insist upon, plead, or in any manner whatsoever claim or take the benefit or advantage of, any stay, extension
or usury law or other law which would prohibit or forgive the Company from paying all or any portion of the principal of or interest
on this Note as contemplated herein, wherever enacted, now or at any time hereafter in force, or which may affect the covenants
or the performance of this indenture, and the Company (to the extent it may lawfully do so) hereby expressly waives all benefits
or advantage of any such law, and covenants that it will not, by resort to any such law, hinder, delay or impede the execution
of any power herein granted to the Holder, but will suffer and permit the execution of every such as though no such law has been
enacted.

 

g)    
Next Business Day. Whenever any payment or other obligation hereunder shall be due on a day other than a Business
Day, such payment shall be made on the next succeeding Business Day.

 

h)    
Headings. The headings contained herein are for convenience only, do not constitute a part of this Note and shall
not be deemed to limit or affect any of the provisions hereof.

 

i)     
Assumption.  Any successor to the Company or any surviving entity in a Sale of Control shall (i) assume, prior
to such Sale of Control, all of the obligations of the Company under this Note and the other Transaction Documents pursuant to
written agreements in form and substance satisfactory to the Holder (such approval not to be unreasonably withheld or delayed)
and (ii) issue to the Holder a new debenture of such successor entity evidenced by a written instrument substantially similar in
form and substance to this Note, including, without limitation, having a principal amount and interest rate equal to the principal
amount and the interest rate of this Note and having similar ranking to this Note, which shall be satisfactory to the Holder (any
such approval not to be unreasonably withheld or delayed).  The provisions of this Section 9(i) shall apply similarly and
equally to successive Sale of Controls and shall be applied without regard to any limitations of this Note.

 

 

(Signature Pages Follow)

 

     

     

    

 

IN WITNESS WHEREOF,
the Company has caused this Note to be duly executed by a duly authorized officer as of the date first above indicated.

 

 

	 	
        Protea Biosciences
        Group, Inc.

         

         

	 	By:	       	 
	 	 	Name: Stephen Turner
	 	 	Title: Chief Executive Officer
	 	 	Facsimile No. for delivery of Notices: 304-292-7101

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