Document:

EX-10.1

 Exhibit 10.1 

CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT 

This Eighth Amended and Restated Investors’ Rights Agreement (this “Agreement”) is made as of January 30, 2017, by
and among Cardiva Medical, Inc., a Delaware corporation (the “Company”), and the Holders (as defined below) listed on Exhibit A hereto. This Agreement amends and restates the Seventh Amended and Restated Investors’
Rights Agreement dated May 29, 2015 (the “Prior Rights Agreement”) entered into among the Company and certain of the Holders. Unless otherwise defined herein, capitalized terms used in this Agreement have the meanings ascribed
to them in Section 1. 
 RECITALS 

WHEREAS, certain of the Holders are parties to the Series 5 Preferred Stock and Warrant Purchase Agreement of even date herewith (as
may be amended from time to time, the “Series 5 Purchase Agreement”), and it is a condition to the closing of the sale Series 5 Preferred Stock to certain of the Holders listed on such Schedule of Investors to the Series 5 Purchase
Agreement that certain Holders and the Company execute and deliver this Agreement; 
 WHEREAS, pursuant to the terms of the Prior
Rights Agreement, neither the Prior Rights Agreement nor any provision thereof may be amended, waived, discharged or terminated other than by written instrument referencing this Agreement and signed by the Company and the holders of at least a
majority of the Registrable Securities (as defined in the Prior Rights Agreement) (excluding any such shares that have been sold to the public or pursuant to Rule 144) (the “Required Parties”); and 

WHEREAS, the Company and each of the undersigned Holders, which include the Required Parties, desire to facilitate the investors’
rights arrangements set forth in this Agreement, amend and restate the Prior Rights Agreement as set forth herein and facilitate the sale and purchase of the shares of Series 5 Preferred pursuant to the Series 5 Purchase Agreement, by agreeing to
the terms and conditions set forth below. 
 NOW, THEREFORE: In consideration of the mutual promises and covenants set forth herein,
and other consideration, the receipt and adequacy of which is hereby acknowledged, the parties hereto agree as follows: 
 Section 1

 Definitions 

1.1 Certain Definitions. As used in this Agreement, the following terms shall have the meanings set forth below: 

(a) “Change of Control” means the acquisition of the Company by another entity by means of any transaction or series of
related transactions to which the Company is party (including, without limitation, any stock acquisition, reorganization, merger or consolidation but excluding any sale of stock for capital raising purposes) other than (a) a merger affected to
change the domicile of the Company or (b) a transaction or series of transactions in which the holders of the voting securities of the Company outstanding immediately prior to such transaction continue to retain (either by such voting
securities remaining outstanding or by such voting securities being converted into voting securities of the surviving entity), as a result of shares in the Company held by such holders prior to such transaction, at least fifty percent (50%) of the
total voting power represented by the voting securities of the Company or such surviving entity outstanding immediately after such transaction or series of transactions; or (c) a sale, lease or other conveyance of all substantially all of the
assets of the Company. 

 (b) “Commission” shall mean the Securities and Exchange Commission or any
other federal agency at the time administering the Securities Act. 
 (c) “Common Stock” means the Common Stock of the
Company. 
 (d) “Exchange Act” shall mean the Securities Exchange Act of 1934, as amended, or any similar successor federal
statute and the rules and regulations thereunder, all as the same shall be in effect from time to time. 
 (e) “Holder”
shall mean: (1) any holder of Registrable Securities; (2) a purchaser of Common Stock upon exercise of a Warrant (provided that such purchaser execute this Agreement upon exercise of such Warrant); and (3) any holder of Registrable
Securities to whom the registration rights conferred by this Agreement have been duly and validly transferred in accordance with Section 2.12 of this Agreement. 

(f) “Indemnified Party” shall have the meaning set forth in Section 2.6(c) hereto. 

(g) “Indemnifying Party” shall have the meaning set forth in Section 2.6(c) hereto. 

(h) “Initial Closing” shall mean the date of the initial sale of shares of the Company’s Series 5 Preferred Stock
pursuant to the Series 5 Purchase Agreement. 
 (i) “Initial Public Offering” shall mean the closing of the Company’s
first firm commitment underwritten initial public offering pursuant to an effective registration statement filed under the Securities Act covering the offer and sale of the Company’s Common Stock. 

(j) “Initiating Holders” shall mean any Holder or Holders who in the aggregate hold not less than fifty percent (50%) of the
outstanding Registrable Securities. 
 (k) “New Securities” shall have the meaning set forth in
Section 4.1(a) hereto. 
 (l) “Preferred Holder” shall mean any holder of Preferred Stock. 

(m) “Preferred Stock” shall mean the Series 3 Preferred Stock, the Series 4 Preferred Stock and Series 5 Preferred Stock. 

(n) “Recapitalization” shall mean any stock dividend, stock split, combination of shares, reorganization, recapitalization,
reclassification or other similar event. 
 (o) “Registrable Securities” shall mean (i) shares of Common Stock issued
or issuable pursuant to the conversion of the Shares, (ii) any Common Stock issued as a dividend or other distribution with respect to or in exchange for or in replacement of the shares referenced in (i) above, and (iii) for purposes
of Section 2 only, Common Stock acquired upon exercise of a Warrant; provided, however, that Registrable Securities shall not include any shares of Common Stock described in clause (i) or (ii) above that have
previously been registered, that have been sold to the public either pursuant to a registration statement or Rule 144, or that have been sold in a private transaction in which the transferor’s rights under this Agreement are not validly
assigned in accordance with this Agreement. 
 (p) The terms “register,” “registered” and
“registration” shall refer to a registration effected by preparing and filing a registration statement in compliance with the Securities Act and applicable rules and regulations thereunder, and the declaration or ordering of the
effectiveness of such registration statement. 

  
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 (q) “Registration Expenses” shall mean all expenses incurred in effecting
any registration pursuant to this Agreement, including, without limitation, all registration, qualification, and filing fees, printing expenses, escrow fees, fees and disbursements of counsel for the Company, fees and disbursements of a single
counsel representing all selling Holders, blue sky fees and expenses, and expenses of any regular or special audits incident to or required by any such registration, but shall not include Selling Expenses and the compensation of regular employees of
the Company. 
 (r) “Restricted Securities” shall mean any Registrable Securities required to bear the first legend set
forth in Section 2.8(c) hereof. 
 (s) “Right of First Refusal Agreement” shall mean that certain
Amended and Restated Right of First Refusal and Co-Sale Agreement, by and between the Company, the Investors and the Stockholders (in each case, as defined therein), dated as of the date hereof, and as may be
amended from time to time. 
 (t) “Rule 144” shall mean Rule 144 as promulgated by the Commission under the Securities Act,
as such Rule may be amended from time to time, or any similar successor rule that may be promulgated by the Commission. 
 (u) “Rule
145” shall mean Rule 145 as promulgated by the Commission under the Securities Act, as such Rule may be amended from time to time, or any similar successor rule that may be promulgated by the Commission 

(v) “Rule 415” shall mean Rule 415 as promulgated by the Commission under the Securities Act, as such Rule may be amended from
time to time, or any similar successor rule that may be promulgated by the Commission. 
 (w) “Securities Act” shall mean
the Securities Act of 1933, as amended, or any similar successor federal statute and the rules and regulations thereunder, all as the same shall be in effect from time to time. 

(x) “Selling Expenses” shall mean all underwriting discounts, selling commissions and stock transfer taxes applicable to the
sale of Registrable Securities and fees and disbursements of counsel for any Holder (other than Registration Expenses associated with a single counsel representing all selling Holders). 

(y) “Series 3 Preferred Stock” shall mean the Company’s Series 3 Preferred Stock. 

(z) “Series 3 Purchase Agreement” shall mean that certain Series 3 Preferred Stock and Warrant Purchase Agreement, by and
between the Company and the purchasers of Series 3 Preferred Stock listed therein, dated on February 7, 2014, as amended from time to time. 

(aa) “Series 4 Preferred Stock” shall mean the Company’s Series 4 Preferred Stock. 

(bb) “Series 4 Purchase Agreement” shall mean that certain Series 4 Preferred Stock and Warrant Purchase Agreement, by and
between the Company and the purchasers of Series 4 Preferred Stock listed therein, dated on May 29, 2015 as amended from time to time. 

(cc) “Series 5 Preferred Stock” shall mean the Company’s Series 5 Preferred Stock. 

  
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 (dd) “Series 5 Purchase Agreement” shall have the meaning set forth in the
Recitals hereto. 
 (ee) “Shares” shall mean shares Preferred Stock. 

(ff) “Withdrawn Registration” shall mean a forfeited demand registration under Section 2.1 in
accordance with the terms and conditions of Section 2.4. 
 Section 2 

Registration Rights 

2.1 Requested Registration. 

(a) Request for Registration. Subject to the conditions set forth in this Section 2.1, if the Company shall
receive from Initiating Holders a written request signed by such Initiating Holders that the Company effect any registration with respect to all or a part of the Registrable Securities (such request shall state the number of shares of Registrable
Securities to be disposed of by such Initiating Holders), the Company will: 
 (i) promptly, and in any event within fifteen (15) days,
give written notice of the proposed registration to all other Holders; and 
 (ii) as soon as practicable, and in any event within ninety
(90) days of such request subject to any limitations set forth in this Section 2.1, file and use its commercially reasonable efforts to effect such registration (including, without limitation, filing post-effective
amendments, appropriate qualifications under applicable blue sky or other state securities laws, and appropriate compliance with the Securities Act) and to permit or facilitate the sale and distribution of all or such portion of such Registrable
Securities as are specified in such request, together with all or such portion of the Registrable Securities of any Holder or Holders joining in such request as are specified in a written request received by the Company within twenty (20) days
after such written notice from the Company is mailed or delivered. 
 (b) Limitations on Requested Registration. The Company shall not
be obligated to effect, or to take any action to effect, any such registration pursuant to this Section 2.1: 

(i) Prior to the earlier of (A) the three (3) year anniversary of the date of this Agreement or (B) one hundred eighty
(180) days following the effective date of the first registration statement filed by the Company covering an underwritten offering of any of its securities to the general public; 

(ii) If the Initiating Holders, together with the holders of any other securities of the Company entitled to inclusion in such registration
statement, propose to sell Registrable Securities and such other securities (if any) the aggregate proceeds of which (after deduction for underwriter’s discounts and expenses related to the issuance) are less than twenty million U.S. dollars
($20,000,000); 
 (iii) In any particular jurisdiction in which the Company would be required to execute a general consent to service of
process in effecting such registration, qualification, or compliance, unless the Company is already subject to service in such jurisdiction and except as may be required by the Securities Act; 

(iv) After the Company has initiated two (2) such registrations pursuant to this Section 2.1 (counting for
these purposes only (x) registrations that have been declared or ordered effective and pursuant to which securities have been sold, and (y) Withdrawn Registrations); 

  
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 (v) During the period starting with the date sixty (60) days prior to the
Company’s good faith estimate of the date of filing of, and ending on a date ninety (90) days after the effective date of, a Company-initiated registration (other than the Company’s initial registration which is addressed under
Section 2.1(b)(i) above); provided that the Company is actively employing in good faith all reasonable efforts to cause such registration statement to become effective; or 

(vi) If the Initiating Holders propose to dispose of shares of Registrable Securities which may be immediately registered on Form S-3 pursuant to a request made under Section 2.3 hereof. 
 (c) Deferral.
If(i) in the good faith judgment of the Board of Directors of the Company, the filing of a registration statement covering the Registrable Securities would be detrimental to the Company and its shareholders and the Board of Directors of the Company
concludes, as a result, that it is in the best interests of the Company to defer the filing of such registration statement at such time, and (ii) the Company shall furnish to such Holders a certificate signed by the President of the Company
stating that in the good faith judgment of the Board of Directors of the Company, it would be detrimental to the Company and its shareholders for such registration statement to be filed in the near future and that it is, therefore, in the best
interests of the Company to defer the filing of such registration statement, then (in addition to the limitations set forth in Section 2.1(b)(v) above) the Company shall have the right to defer such filing for a period of
not more than sixty (60) days after receipt of the request of the Initiating Holders, and, provided further, that the Company shall not defer its obligation in this manner more than twice in any twelve (12) month period. 

(d) Underwriting. If the Initiating Holders intend to distribute the Registrable Securities covered by their request pursuant to this
Section 2.1 by means of an underwriting, they shall so advise the Company as a part of their request made pursuant to this Section 2.1 and the Company shall include such information in the written
notice given pursuant to Section 2.1(a)(i). In such event, the right of any Holder to include all or any portion of its Registrable Securities in such registration pursuant to this
Section 2.1 shall be conditioned upon such Holder’s participation in such an underwriting and the inclusion of such Holder’s Registrable Securities to the extent provided herein. If the Company shall request
inclusion in any registration pursuant to Section 2.1 of securities being sold for its own account, or if other persons shall request inclusion in any registration pursuant to Section 2.1, the
Initiating Holders shall, on behalf of all Holders, offer to include such securities in the underwriting and such offer shall be conditioned upon the participation of the Company or such other persons in such underwriting and the inclusion of the
Company’s and such person’s other securities of the Company and their acceptance of the further applicable provisions of this Section 2 (including Section 2.10). The Company shall select
the underwriters (subject to the approval of the Initiating Holders holding a majority of Registrable Securities to be included in such underwriting, which such approval shall not be unreasonably withheld or delayed) and (together with all Holders
proposing to distribute their securities through such underwriting) enter into an underwriting agreement in customary form with the representative of the underwriter or underwriters selected for such underwriting. 

Notwithstanding any other provision of this Section 2.1, if the underwriters advise the Initiating Holders in
writing that marketing factors require a limitation on the number of shares to be underwritten, the number of Registrable Securities that may be so included shall be allocated as follows: (i) first, among all Holders requesting to include
Registrable Securities in such registration statement based on the pro rata percentage of Registrable Securities held by such Holders; and (ii) second, to the Company, which the Company may allocate, at its discretion, for its own account, or
for the account of other holders or employees of the Company; provided, however, that the number of shares of Registrable Securities to be included in such underwriting shall not be reduced unless all other securities are first entirely excluded
from the underwriting. 

  
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 If a person who has requested inclusion in such registration as provided above does not
agree to the terms of any such underwriting, such person shall be excluded therefrom by written notice from the Company, the underwriter or the Initiating Holders. The securities so excluded shall also be withdrawn from registration. Any Registrable
Securities or other securities excluded or withdrawn from such underwriting shall also be withdrawn from such registration. If shares are so withdrawn or excluded from the registration and if the number of shares to be included in such registration
was previously reduced as a result of marketing factors pursuant to this Section 2.1(d), then the Company shall then offer to all Holders who have retained rights to include securities in the registration the right to
include additional Registrable Securities in the registration in an aggregate amount equal to the number of shares so withdrawn or excluded, with such shares to be allocated pro rata among such Holders requesting additional inclusion, as set forth
above. 
 2.2 Company Registration. 

(a) Company Registration. If the Company shall determine to register any of its securities either for its own account or the account of
a security holder or holders, other than a registration pursuant to Section 2.1 or 2.3, a registration relating solely to employee benefit plans, a registration relating to the offer and sale of debt securities, a
registration relating to a corporate reorganization or other Rule 145 transaction, or a registration on any registration form that does not permit secondary sales, the Company will: 

(i) promptly, and in any event within fifteen (15) days, give written notice of the proposed registration to all Holders; and 

(ii) use its commercially reasonable efforts to include in such registration (and any related qualification under blue sky laws or other
compliance), except as set forth in Section 2.2(b) below, and in any underwriting involved therein, all of such Registrable Securities as are specified in a written request or requests made by any Holder or Holders received
by the Company within ten (10) days after such written notice from the Company is mailed or delivered. Such written request may specify all or a part of a Holder’s Registrable Securities. 

(b) Underwriting. If the registration of which the Company gives notice is for a registered public offering involving an underwriting,
the Company shall so advise the Holders as a part of the written notice given pursuant to Section 2.2(a)(i). In such event, the right of any Holder to registration pursuant to this
Section 2.2 shall be conditioned upon such Holder’s participation in such underwriting and the inclusion of such Holder’s Registrable Securities in the underwriting to the extent provided herein. All Holders
proposing to distribute their securities through such underwriting shall (together with the Company and the other holders of securities of the Company with registration rights to participate therein distributing their securities through such
underwriting) enter into an underwriting agreement in customary form with the representative of the underwriter or underwriters selected by the Company. 

Notwithstanding any other provision of this Section 2.2, if the underwriters advise the Company that marketing
factors require a limitation on the number of shares to be underwritten, the underwriters may (subject to the limitations set forth below) exclude all Registrable Securities from, or limit the number of Registrable Securities to be included in, the
registration and underwriting; provided that the foregoing limitation may only be applied after the Company has excluded from such registration all securities held by holders other than holders of Registrable Securities that the Company intends to
include in such registration; and provided further following the Company’s Initial Public Offering, the number of Registrable Securities to be included in any such registration shall not be reduced below twenty percent (20%) of the number of
shares to be underwritten. The Company shall so advise all holders of securities requesting registration, and the number of shares of securities that are entitled to be included in the registration and underwriting shall be allocated, as follows:
(i) first, to the Company for securities being sold for its own account and (ii) second, to the Holders requesting to include Registrable Securities in such registration statement based on the pro rata percentage of Registrable Securities
held by such Holders. 

  
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 If a person who has requested inclusion in such registration as provided above does not
agree to the terms of any such underwriting, such person shall also be excluded therefrom by written notice from the Company or the underwriter. The Registrable Securities or other securities so excluded shall also be withdrawn from such
registration. Any Registrable Securities or other securities excluded or withdrawn from such underwriting shall be withdrawn from such registration. 

If shares are so withdrawn or excluded from the registration and if the number of shares of Registrable Securities to be included in such
registration was previously reduced as a result of marketing factors, the Company shall use its commercially reasonable efforts to offer to all persons who have retained the right to include securities in the registration the right to include
additional securities in the registration in an aggregate amount equal to the number of shares so withdrawn or excluded, with such shares to be allocated pro rata among the persons requesting additional inclusion in accordance with
Section 2.2 hereof. 
 (c) Right to Terminate Registration. The Company shall have the right to terminate or
withdraw any registration initiated by it under this Section 2.2 prior to the effectiveness of such registration whether or not any Holder has elected to include securities in such registration. The Registration Expenses of
such withdrawn registration shall be borne by the Company in accordance with Section 2.4 hereof. 
 2.3
Registration on Form S-3. 
 (a) Request for Form
S-3 Registration. After its Initial Public Offering, the Company shall use its commercially reasonable efforts to qualify for registration on Form S-3 or any
comparable or similar short form registration statement or successor form or forms (“Form S-3”). After the Company has qualified for the use of Form
S-3, in addition to the rights contained in the foregoing provisions of this Section 2 and subject to the conditions set forth in this Section 2.3, if the
Company shall receive from Holders of not less than ten percent (10%) of the Registrable Securities a written request that the Company effect any registration on Form S-3 with respect to all or part of the
Registrable Securities (such request shall state the number of shares of Registrable Securities to be disposed of and the intended methods of disposition of such shares by such Holders), the Company will take all such action with respect to such
Registrable Securities as required by Section 2.1(a)(i) and (ii). 
 (b) Limitations on Form S-3 Registration. The Company shall not be obligated to effect, or take any action to effect, any such registration pursuant to this Section 2.3: 

(i) In the circumstances described in either Sections 2.1(b)(i), 2.1(b)(iii) or 2.1(b)(v); 

(ii) If the Holders, together with the holders of any other securities of the Company entitled to inclusion in such registration, propose to
sell Registrable Securities and such other securities (if any) on Form S-3 at an aggregate price to the public of less than one million U.S. dollars ($1,000,000); or 

(iii) If, in a given six (6) month period, the Company has effected one (1) such registration in such period. 

(c) Deferral. If (i) in the good faith judgment of the Board of Directors of the Company, the filing of a registration statement on
Form S-3 covering the Registrable Securities would be detrimental to the Company and its shareholders and the Board of Directors of the Company concludes, as a result, that it is in the best interests of the
Company to defer the filing of such registration statement on Form S-3 at such time, and (ii) the Company shall furnish to such Holders a certificate signed by the President of the Company stating that in
the good faith judgment of the Board of Directors of the Company, it would be detrimental to the 

  
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Company and its shareholders for such registration statement to be filed in the near future and that it is, therefore, in the best interests of the Company to defer the filing of such
registration statement on Form S-3, then (in addition to the limitations set forth in Section 2.1(b)(v) above) the Company shall have the right to defer such filing for a period of
not more than ninety (90) days after receipt of the request of the Initiating Holders, and, provided further, that the Company shall not defer its obligation in this manner more than once in any twelve (12) month period. 

(d) Underwriting. If the Holders of Registrable Securities requesting registration under this Section 2.3
intend to distribute the Registrable Securities covered by their request by means of an underwriting, the provisions of Sections 2.1(e) shall apply to such registration. Notwithstanding anything contained herein to the contrary, registrations
effected pursuant to this Section 2.3 shall not be counted as requests for registration or registrations effected pursuant to Section 2.1. 

2.4 Expenses of Registration. All Registration Expenses incurred in connection with registrations pursuant to Sections 2.1,
2.2 and 2.3 hereof shall be borne by the Company; provided, however, that the Company shall not be required to pay for any expenses of any registration proceeding begun pursuant to Sections 2.1 and 2.3 if (i) the
withdrawal of such registration proceeding is based upon material adverse information concerning the Company which was known to the Holders requesting registration at the time of such request or (ii) the registration request is subsequently
withdrawn at the request of the Holders of a majority of the Registrable Securities to be registered or because a sufficient number of Holders shall have withdrawn so that the minimum offering conditions set forth in Sections 2.1 and 2.3 are no
longer satisfied (in which case all participating Holders shall bear such expenses pro rata among each other based on the number of Registrable Securities requested to be so registered), unless the Holders of a majority of the Registrable Securities
agree to forfeit their right to a demand registration pursuant to Section 2.1 (in which case such Registration Expenses shall be borne by the Company). All Selling Expenses relating to securities registered on behalf of the
Holders shall be borne by the holders of securities included in such registration pro rata among each other on the basis of the number of Registrable Securities so registered. 

2.5 Registration Procedures. In the case of each registration effected by the Company pursuant to Section 2,
the Company will keep each Holder advised in writing as to the initiation of each registration and as to the completion thereof. At its expense, the Company will use its commercially reasonable efforts to: 

(a) Keep such registration effective for a period ending on the earlier of the date which is ninety (90) days from the effective date of
the registration statement or such time as the Holder or Holders have completed the distribution described in the registration statement relating thereto; provided, however, that such ninety (90) day period shall be extended for a period of
time equal to the period the Holder agrees to refrain from selling any securities included in such registration at the request of the Company or an underwriter of Common Stock of the Company; 

(b) Prepare and file with the Commission such amendments and supplements to such registration statement and the prospectus used in connection
with such registration statement as may be necessary to comply with the provisions of the Securities Act with respect to the disposition of all securities covered by such registration statement for the period set forth in subsection (a) above;

 (c) Furnish such number of prospectuses, including any preliminary prospectuses, and other documents incident thereto, including any
amendment of or supplement to the prospectus, as a Holder from time to time may reasonably request; 
 (d) Use its reasonable best efforts to
register and qualify the securities covered by such registration statement under such other securities or Blue Sky laws of such jurisdiction as shall be reasonably requested by the Holders; provided, that the Company shall not be required in
connection therewith or as a condition thereto to qualify to do business or to file a general consent to service of process in any such states or jurisdictions; 

  
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 (e) Notify each seller of Registrable Securities covered by such registration statement at
any time when a prospectus relating thereto is required to be delivered under the Securities Act of the happening of any event as a result of which the prospectus included in such registration statement, as then in effect, includes an untrue
statement of a material fact or omits to state a material fact required to be stated therein or necessary to make the statements therein not misleading or incomplete in light of the circumstances then existing, and following such notification
promptly prepare and furnish to such seller a reasonable number of copies of a supplement to or an amendment of such prospectus as may be necessary so that, as thereafter delivered to the purchasers of such shares, such prospectus shall not include
an untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the statements therein not misleading or incomplete in light of the circumstances then existing; 

(f) Provide a transfer agent and registrar for all Registrable Securities registered pursuant to such registration statement and a CUSIP number
for all such Registrable Securities, in each case not later than the effective date of such registration; 
 (g) Cause all such Registrable
Securities registered pursuant hereunder to be listed on each securities exchange or nationally recognized quotation system on which similar securities issued by the Company are then listed or quoted; 

(h) In connection with any underwritten offering pursuant to a registration statement filed pursuant to Section 2.1
and, if applicable, Section 2.3 hereof, enter into an underwriting agreement in form reasonably necessary to effect the offer and sale of Common Stock, provided such underwriting agreement contains reasonable and customary
provisions, and provided further, that each Holder participating in such underwriting shall also enter into and perform its obligations under such an agreement; and 

(i) Furnish, at the request of the Holders of at least five hundred thousand (500,000) shares of Registrable Securities (as adjusted for stock
splits, stock dividends, reverse stock splits, stock combinations or other similar capitalization changes) requesting registration of Registrable Securities pursuant to this Section 2, on the date that such Registrable
Securities are delivered to the underwriters for sale in connection with a registration pursuant to this Section 2, if such securities are being sold through underwriters, (i) an opinion, dated such date, of the
counsel representing the Company for the purposes of such registration, in form and substance as is customarily given to underwriters in an underwritten public offering, addressed to the underwriters, if any, and to the Holders requesting
registration of Registrable Securities and (ii) a letter dated such date, from the independent certified public accountants of the Company, in form and substance as is customarily given by independent certified public accountants to
underwriters in an underwritten public offering, addressed to the underwriters, if any, and to the Holders requesting registration of Registrable Securities. 

2.6 Indemnification. In the event that any Registrable Securities are included in a registration statement pursuant to Sections
2.1, 2.2 or 2.3 hereof: 
 (a) To the extent permitted by law, the Company will indemnify and hold harmless each Holder,
each of its officers, directors and partners, legal counsel, and accountants and each person controlling such Holder within the meaning of Section 15 of the Securities Act, with respect to which registration, qualification, or compliance has
been effected pursuant to this Section 2, and each underwriter, if any, and each person who controls within the meaning of Section 15 of the Securities Act any underwriter, against all expenses, claims, losses,
damages, and liabilities (or actions, proceedings, or settlements in respect thereof) arising out of or based on: (i) any untrue statement (or alleged untrue statement) of a material fact contained

  
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or incorporated by reference in any prospectus, offering circular, or other document (including any related registration statement, notification, or the like) incident to any such registration,
qualification, or compliance, (ii) any omission (or alleged omission) to state therein a material fact required to be stated therein or necessary to make the statements therein not misleading, or (iii) any violation (or alleged violation)
by the Company of the Securities Act, the Exchange Act, any state securities laws or any rule or regulation thereunder applicable to the Company and relating to action or inaction required of the Company in connection with any offering covered by
such registration, qualification, or compliance (a “Violation”), and the Company will reimburse each such Holder, each of its officers, directors, partners, legal counsel, and accountants and each person controlling such Holder,
each such underwriter, and each person who controls any such underwriter, for any legal and any other expenses reasonably incurred in connection with investigating and defending or settling any such claim, loss, damage, liability, or action;
provided that the Company will not be liable in any such case to the extent that any such claim, loss, damage, liability, or action arises out of or is based on any untrue statement or omission based directly upon written information furnished to
the Company by such Holder, any of such Holder’s officers, directors, partners, legal counsel or accountants, any person controlling such Holder, such underwriter or any person who controls any such underwriter and stated to be specifically for
use therein; and provided, further that, the indemnity agreement contained in this Section 2.6(a) shall not apply to amounts paid in settlement of any such loss, claim, damage, liability, or action if such settlement is
effected without the consent of the Company (which consent shall not be unreasonably withheld or delayed). 
 (b) To the extent permitted by
law, each Holder will, if Registrable Securities held by such Holder are included in the securities as to which such registration, qualification, or compliance is being effected, indemnify and hold harmless the Company, each of its directors,
officers, partners, legal counsel, and accountants and each underwriter, if any, of the Company’s securities covered by such a registration statement, each person who controls the Company or such underwriter within the meaning of
Section 15 of the Securities Act, each other such other Holder, and each of their officers, directors, and partners, and each person controlling such other Holder, against all claims, losses, damages and liabilities (or actions in respect
thereof) arising out of or based on: (i) any untrue statement (or alleged untrue statement) of a material fact contained or incorporated by reference in any such registration statement, prospectus, offering circular, or other document, or
(ii) any omission (or alleged omission) to state therein a material fact required to be stated therein or necessary to make the statements therein not misleading, and will reimburse the Company and such Holders, directors, officers, partners,
legal counsel, and accountants, persons, underwriters, or control persons for any legal or any other expenses reasonably incurred in connection with investigating or defending any such claim, loss, damage, liability, or action, in each case to the
extent, but only to the extent, that such untrue statement (or alleged untrue statement) or omission (or alleged omission) is made in such registration statement, prospectus, offering circular, or other document in reliance upon and in conformity
with written information furnished to the Company by such Holder and stated to be specifically for use therein; provided, however, that the obligations of such Holder hereunder shall not apply to amounts paid in settlement of any such claims,
losses, damages, or liabilities (or actions in respect thereof) if such settlement is effected without the consent of such Holder (which consent shall not be unreasonably withheld or delayed); and provided that in no event shall any indemnity under
this Section 2.6 exceed the net proceeds from the offering received by such Holder. 
 (c) Each party entitled to
indemnification under this Section 2.6 (the “Indemnified Party”) shall give notice to the party required to provide indemnification (the “Indemnifying Party”) promptly after such
Indemnified Party has actual knowledge of any claim as to which indemnity may be sought, and shall permit the Indemnifying Party to assume the defense of such claim or any litigation resulting therefrom; provided that counsel for the
Indemnifying Party, who shall conduct the defense of such claim or any litigation resulting therefrom, shall be approved by the Indemnified Party (whose approval shall not be unreasonably withheld or delayed), and the Indemnified Party may
participate in such defense at such party’s expense; and provided further that the failure of any Indemnified Party to give notice as provided herein shall not relieve the Indemnifying Party of its obligations under this
Section 2.6, to the extent such failure is not prejudicial. No Indemnifying Party, in the defense of any such claim or litigation, shall, except with the consent 

  
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of each Indemnified Party, consent to entry of any judgment or enter into any settlement that does not include as an unconditional term thereof the giving by the claimant or plaintiff to such
Indemnified Party of a release from all liability in respect to such claim or litigation. Each Indemnified Party shall furnish such information regarding itself or the claim in question as an Indemnifying Party may reasonably request in writing and
as shall be reasonably required in connection with defense of such claim and litigation resulting therefrom. 
 (d) If the indemnification
provided for in this Section 2.6 is held by a court of competent jurisdiction to be unavailable to an Indemnified Party with respect to any loss, liability, claim, damage, or expense referred to herein, then the
Indemnifying Party, in lieu of indemnifying such Indemnified Party hereunder, shall contribute to the amount paid or payable by such Indemnified Party as a result of such loss, liability, claim, damage, or expense in such proportion as is
appropriate to reflect the relative fault of the Indemnifying Party on the one hand and of the Indemnified Party on the other in connection with the statements or omissions that resulted in such loss, liability, claim, damage, or expense as well as
any other relevant equitable considerations. The relative fault of the Indemnifying Party and of the Indemnified Party shall be determined by reference to, among other things, whether the untrue or alleged untrue statement of a material fact or the
omission to state a material fact relates to information supplied by the Indemnifying Party or by the Indemnified Party and the parties’ relative intent, knowledge, access to information, and opportunity to correct or prevent such statement or
omission. The parties hereto agree that it would not be just and equitable if contribution pursuant to this Section 2.6(d) were determined by pro rata allocation or by any other method of allocation that does not
take account of the equitable considerations referred to in the immediately preceding sentence. Notwithstanding the provision of this Section 2.6(d), an Indemnifying Party that is a selling Holder of Registrable Securities
shall not be required to contribute any amount in excess of the amount by which the total price at which the Registrable Securities sold by such Indemnifying Party exceeds the amount of any damages that such Indemnifying Party has otherwise been
required to pay by reason of such untrue or alleged untrue statement or omission or alleged omission. No person found guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the Securities Act) by a court of competent
jurisdiction shall be entitled to contribution from any Person who was not found guilty of such fraudulent misrepresentation by a court of competent jurisdiction. 

(e) Notwithstanding the foregoing, to the extent that the provisions on indemnification and contribution contained in the underwriting
agreement entered into in connection with the underwritten public offering are in conflict with the foregoing provisions, the provisions in the underwriting agreement shall control. 

2.7 Information by Holder. Each Holder of Registrable Securities shall furnish to the Company such information regarding such Holder and
the distribution proposed by such Holder as the Company may reasonably request in writing and as shall be reasonably required in connection with any registration, qualification, or compliance referred to in this Section 2.

 2.8 Restrictions on Transfer. 

(a) Each holder of Company securities party to this Agreement (each, a “Securityholder”), by acceptance thereof agrees to
comply in all respects with the provisions of this Section 2.8. Each Securityholder agrees not to make any sale, assignment, transfer, pledge or other disposition of all or any Company securities, or any beneficial interest
therein, unless and until (x) the transferee thereof has agreed in writing for the benefit of the Company to take and hold such securities subject to, and to be bound by, the terms and conditions set forth in this Agreement, including, without
limitation, this Section 2.8 and Section 2.10, except for transfers permitted under Section 2.8(b), and (y): 

  
 -11- 

 (i) There is then in effect a registration statement under the Securities Act covering such
proposed disposition and such disposition is made in accordance with such registration statement; or 
 (ii) Such Securityholder shall have
given prior written notice to the Company of such Securityholder’ s intention to make such disposition and shall have furnished the Company with a detailed description of the manner and circumstances of the proposed disposition, and, such
Securityholder shall have furnished the Company, at its expense, with (i) an opinion of counsel, reasonably satisfactory to the Company, to the effect that such disposition will not require registration of such securities under the Securities
Act or (ii) a “no action” letter from the Commission to the effect that the transfer of such securities without registration will not result in a recommendation by the staff of the Commission that action be taken with respect thereto,
whereupon the Securityholder shall be entitled to transfer such securities in accordance with the terms of the notice delivered by the Securityholder to the Company. 

(b) Permitted transfers include (i) a transfer not involving a change in beneficial ownership, or (ii) in transactions involving the
distribution of securities by any Securityholder to (x) a parent, subsidiary or other affiliate of the Securityholder that is a corporation, or (y) any of its partners, members or other equity owners, or retired partners, retired members
or other equity owners, or to the estate of any of its partners, members or other equity owners or retired partners, retired members or other equity owners, (iii) transfers without consideration in connection with a liquidation, dissolution or
winding up of a Securityholder, or (iv) transfers in compliance with Rule 144, as long as the Company is furnished with satisfactory evidence of compliance with such Rule; provided, in each case, that the Securityholder thereof shall give
written notice to the Company of such Securityholder’s intention to effect such disposition and shall have furnished the Company with a detailed description of the manner and circumstances of the proposed disposition. 

(c) Each certificate representing securities held by a Securityholder shall (unless otherwise permitted by the provisions of this Agreement) be
stamped or otherwise imprinted with a legend substantially similar to the following (in addition to any legend required under applicable state securities laws): 

THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR UNDER
THE SECURITIES LAWS OF CERTAIN STATES. THESE SECURITIES MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED, PLEDGED OR HYPOTHECATED EXCEPT AS PERMITTED UNDER THE ACT AND APPLICABLE STATE SECURITIES LAWS PURSUANT TO REGISTRATION OR AN EXEMPTION
THEREFROM. THE ISSUER OF THESE SECURITIES MAY REQUIRE AN OPINION OF COUNSEL SATISFACTORY TO THE ISSUER THAT SUCH OFFER, SALE OR TRANSFER, PLEDGE OR HYPOTHECATION OTHERWISE COMPLIES WITH THE ACT AND ANY APPLICABLE STATE SECURITIES LAWS. 

THE SHARES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO (1) RESTRICTIONS ON TRANSFERABILITY AND RESALE, INCLUDING A LOCK-UP PERIOD IN THE EVENT OF A PUBLIC OFFERING, AS SET FORTH IN AN INVESTORS’ RIGHTS AGREEMENT, AND (2) VOTING RESTRICTIONS AS SET FORTH IN A VOTING AGREEMENT AMONG THE COMPANY AND THE ORIGINAL HOLDERS
OF THESE SHARES, COPIES OF WHICH MAY BE OBTAINED AT THE PRINCIPAL OFFICE OF THE COMPANY. 
 Each Securityholder consents to the Company
making a notation on its records and g1vmg instructions to any transfer agent of such Securityholder’s securities in order to implement the restrictions on transfer established in this Section 2.8. 

  
 -12- 

 (d) The first legend referring to federal and state securities laws identified in
Section 2.8(c) hereof stamped on a certificate evidencing the securities held by Securityholders and the stock transfer instructions and record notations with respect to such securities shall be removed and the Company
shall issue a certificate without such legend to the holder of such securities if (i) such securities are registered under the Securities Act, or (ii) such holder provides the Company with an opinion of counsel reasonably acceptable to the
Company to the effect that a public sale or transfer of such securities may be made without registration under the Securities Act, or (iii) such holder provides the Company with reasonable assurances, which may, at the option of the Company,
include an opinion of counsel satisfactory to the Company, that such securities can be sold pursuant to Rule 144 under the Securities Act. 

2.9 Rule 144 Reporting. With a view to making available the benefits of certain rules and regulations of the Commission that may permit
the sale of the Restricted Securities to the public without registration, the Company agrees to use its reasonable best efforts to: 
 (a)
Make and keep public information regarding the Company available as those terms are understood and defined in Rule 144 under the Securities Act, at all times from and after ninety (90) days following the effective date of the first registration
under the Securities Act filed by the Company for an offering of its securities to the general public; 
 (b) File with the Commission in a
timely manner all reports and other documents required of the Company under the Securities Act and the Exchange Act at any time after it has become subject to such reporting requirements; and 

(c) So long as a Holder owns any Restricted Securities, furnish to the Holder forthwith upon written request a written statement by the Company
as to its compliance with the reporting requirements of Rule 144 (at any time from and after ninety (90) days following the effective date of the first registration statement filed by the Company for an offering of its securities to the general
public), and of the Securities Act and the Exchange Act (at any time after it has become subject to such reporting requirements), a copy of the most recent annual or quarterly report of the Company, and such other reports and documents so filed as a
Holder may reasonably request in availing itself of any rule or regulation of the Commission allowing a Holder to sell any such securities without registration. 

2.10 Market Stand-Off Agreement. Each Securityholder hereby agrees that such Securityholder
shall not sell or otherwise transfer, make any short sale of, grant any option for the purchase of, or enter into any hedging or similar transaction with the same economic effect as a sale, of any Common Stock (or other securities) of the Company
held by such Securityholder (other than those included in the registration), during the period beginning on the date the Company files a registration statement to effect the Company’s Initial Public Offering and ending one hundred eighty
(180) days following the effective date of the Company’s Initial Public Offering filed under the Securities Act (or such longer period of time as may be required to accommodate regulatory restrictions on (x) the publication or other
distribution of research reports and (y) analyst recommendations and opinions, including, but not limited to, the restrictions contained in FINRA Rule 271 l(f)(4) or NYSE Rule 472(0)(4), as applicable, (or any successor rules or amendments
thereto)) (the “Market Standoff Period”); provided, however, that such agreement shall only be applicable if all officers, directors and holders of at least one percent (1%) of the outstanding capital stock of the Company are
similarly bound; and provided, further, if the Company or the underwriters shall release any Registrable Securities or any other securities (the “Released Securities”) from the requirements of this
Section 2.10 before the end of the period set by the Company or the underwriters, then the Registrable Securities of each Holder shall be released from the provisions of this Section 2.10 in the
same proportion as the Released Securities bear to the total number of securities held by such Holder which were subject to this Section 2.10. The obligations described in this Section 2.10 shall
not apply to a registration relating solely to employee benefit plans on Form S-1 or Form S-8 or similar forms that may be promulgated in the future, or a registration
relating solely 

  
 -13- 

 
to a Rule 145 transaction. The Company may impose stop-transfer instructions and may stamp each such certificate with the second legend set forth in Section 2.8(c)
hereof with respect to the shares of Common Stock (or other securities) subject to the foregoing restriction until the end of the Market Standoff Period. Each Securityholder agrees to execute a market standoff agreement with said underwriters in
customary form consistent with the provisions of this Section 2.10. 
 2.11 Delay of Registration. No Holder
shall have any right to take any action to restrain, enjoin, or otherwise delay any registration as the result of any controversy that might arise with respect to the interpretation or implementation of this Section 2. 

2.12 Transfer or Assignment of Registration Rights. The rights to cause the Company to register securities granted to a Holder by the
Company under this Section 2 may be transferred or assigned by a Holder only to a transferee or assignee of not less than two hundred thousand (200,000) shares of Registrable Securities (as presently constituted and subject
to subsequent adjustments for stock splits, stock dividends, reverse stock splits, and the like); provided that (i) such transfer or assignment of Registrable Securities is effected in accordance with the terms of
Section 2.8 hereof, the Right of First Refusal and Co-Sale Agreement, and applicable securities laws, (ii) the Company is given prompt written notice of such transfer or
assignment, stating the name and address of the transferee or assignee and identifying the securities with respect to which such registration rights have been transferred or assigned and (iii) the transferee or assignee of such rights assumes
in writing the obligations of such Holder under this Agreement, including without limitation the obligations set forth in Section 2.10. 

2.13 Limitations on Subsequent Registration Rights. From and after the date of this Agreement, the Company shall not, without the prior
written consent of Holders of at least a majority of the Registrable Securities, enter into any agreement with any holder or prospective holder of any securities of the Company giving such holder or prospective holder any registration rights the
terms of which are senior to the registration rights granted to the Holders hereunder. 
 2.14 Termination of Registration Rights. The
right of any Holder to request registration or inclusion in any registration pursuant to Section 2.1, 2.2 or 2.3 shall terminate on the earliest of (i) such date, on or after the closing of the
Company’s Initial Public Offering, on which all shares of Registrable Securities held or entitled to be held upon conversion by such Holder may immediately be sold pursuant Rule 144 under the Securities Act during any ninety (90)-day period, (ii) four (4) years after the closing of the Company’s Initial Public Offering or (iii) nine (9) years after the closing of the Company’s Initial Public Offering for
“affiliates” (as such term is defined in Rule 144 under the Securities Act). 
 Section 3 

Covenants of the Company 

The Company hereby covenants and agrees, as follows: 

3.1 Information Rights. 

(a) Basic Financial Information. The Company will furnish the following reports to each Preferred Holder who owns at least four hundred
thousand (400,000) shares of Preferred Stock (as presently constituted and subject to subsequent adjustments for stock splits, stock dividends, reverse stock splits, and the like) (a “Major Investor”); provided that all shares of
Preferred Stock held or acquired by “affiliates” (as such term is defined in Rule 144 under the Securities Act) of a Preferred Holder shall be aggregated together with the shares of Preferred Stock held by such Preferred Holder for the
purpose of determining the availability of any rights under this Section 3: 

  
 -14- 

 (i) As soon as practicable after the end of each fiscal year of the Company, and in any
event within ninety (90) days after the end of each fiscal year of the Company, an audited consolidated balance sheet of the Company and its subsidiaries, if any, as at the end of such fiscal year, and audited consolidated statements of income
and cash flows of the Company and its subsidiaries, if any, for such year, prepared in accordance with U.S. generally accepted accounting principles consistently applied, certified by independent public accountants of recognized national standing
selected by the Board of Directors of the Company. 
 (ii) As soon as practicable after the end of the first, second and third quarterly
accounting periods in each fiscal year of the Company, and in any event within thirty (30) days after the end of the first, second, and third quarterly accounting periods in each fiscal year of the Company, an unaudited consolidated balance
sheet of the Company and its subsidiaries, if any, as of the end of each such quarterly period, and unaudited consolidated statements of income and cash flows of the Company and its subsidiaries, if any, for such period, prepared in accordance with
U.S. generally accepted accounting principles consistently applied, subject to changes resulting from normal year-end audit adjustments. 

(iii) A soon as practicable after the end of each calendar month (excluding those months wherein the Major Investor will receive financial
information pursuant to Sections 3.1(a)(i) and (ii) above) in each fiscal year of the Company, and in any event within ten (10) business days after the end of each calendar month in each fiscal year of the Company, an
unaudited consolidated balance sheet of the Company and its subsidiaries, if any, as of the end of such calendar month, and unaudited consolidated statements of income and cash flows of the Company and its subsidiaries, if any, for such calendar
month, prepared in accordance with U.S. generally accepted accounting principles consistently applied, subject to changes resulting from normal year-end audit adjustments. 

(b) Annual Budget. The Company shall furnish the annual budget for a particular fiscal year to each Major Investor on the earlier of
(i) thirty (30) days prior to the beginning of a fiscal year if such annual budget has been approved by the Board of Directors or (ii) within fifteen (15) days of the approval of such annual budget by the Company’s Board of
Directors. 
 (c) Inspection Rights. The Company shall permit each Major Investor to visit and inspect the properties of the Company,
to examine its corporate and financial records and make copies thereof and to discuss its affairs, finances, and accounts with its executive officers, at such reasonable times during normal business hours and upon such reasonable notice of no less
than three (3) business days; provided that (i) the Company consent to such inspection, which such consent shall not be unreasonably withheld and (ii) that such eligible Preferred Holder agrees to abide by all Company policies, rules
and regulations, including those regarding access to restricted areas on the Company’s properties and confidentiality. 
 3.2
Confidentiality. Anything in this Agreement to the contrary notwithstanding, no Holder by reason of this Agreement shall have access to any trade secrets or classified information of the Company. The Company shall not be required to comply
with any information rights of Section 3 in respect of any Holder whom the Board of Directors of the Company reasonably determines to be a competitor or an officer, employee, director or holder of more than ten percent
(10%) of a competitor. Each Holder acknowledges that the information received by them pursuant to this Agreement may be confidential and for its internal use only, and it will not use such confidential information in violation of the Exchange Act or
reproduce, disclose or disseminate such information to any other person (other than its employees or agents having a need to know the contents of such information, and its attorneys), except in connection with the exercise of rights under this
Agreement, unless such information has become available to the public generally without any breach by the Holder of this Section 3.2. 

  
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 3.3 Reservation of Common Stock. On and after the date hereof, the Company will
reserve and keep reserved at all times sufficient shares of Common Stock for issuance upon conversion of the Shares. Immediately prior to the occurrence of any event that would cause the number of shares of Common Stock or type of securities into
which the Shares would be convertible to be adjusted, the Company shall take any and all actions necessary to permit such conversion. 
 3.4
Use of Proceeds. The proceeds from the sale of the Series 5 Preferred pursuant to the Series 5 Purchase Agreement (the “Proceeds”) may be used by the Company for working capital, capital expenditures, sales and marketing and
research and development. 
 3.5 Protection of Intellectual Property. The Company shall use commercially reasonable efforts to protect
its proprietary intellectual property, trade secrets and know-how, including, but not limited to, (i) the keeping of proper laboratory notebooks, (ii) the use of secure storage, and
(iii) obtaining proprietary information and invention assignment agreements, which shall include appropriate confidentiality provisions, from all employees and consultants (excluding the members of the Company’s advisory board), upon the
commencement of their employment or service to the Company, in substantially the form delivered to the Investors, subject to amendments approved by the Company’s Board of Directors and which agreements shall be reviewed and renewed, if
necessary, on an annual basis as determined by the Board of Directors. 
 3.6 Observer Rights. So long as each of Galen Partners IV,
L.P. and its affiliated entities (collectively, “Galen”), Sycamore Ventures Pte Ltd. and its affiliated entities (collectively, “Sycamore”), TriVentures II Fund L.P. and its affiliated entities (collectively,
“TriVentures”) and PTV IV, L.P. and its affiliated entities (collectively, “PTV”), individually and not collectively, hold shares of the Company’s capital stock (each an “Investor with Observer
Rights”), the Company covenants and agrees that each Investor with Observer Rights shall each be entitled to designate one observer (each an “Observer” and together, the “Observers”). The Observers may be
present at all meetings of the Board and any committees thereof, including any telephonic meetings and executive sessions, and that the Company will give such Observers notice of such meetings, by telecopy or by such other means as such notices are
delivered to the members of the Board, not later than the same time notice is provided or delivered to the Board; provided, that the Observers shall be subject to the confidentiality provisions set forth in
Section 3.2 hereof; provided, further, that the Observers may be excluded from access to any material or meeting or portion thereof (i) if the Company believes upon advice of counsel that such exclusion is reasonably
necessary to preserve the attorney-client privilege, (ii) to protect confidential or proprietary information or (iii) for other similar reasons. For purposes of clarity, nothing herein shall be construed to mean that in the event that
Galen, Sycamore, TriVentures or PTV is no longer an Investor with Observer Rights, that any other Investors with Observer Rights shall lose their right pursuant to this Section 3.6 to designate an Observer. 

3.7 Termination of Covenants. The covenants set forth in this Section 3 shall terminate and be of no further
force and effect with respect to the earliest to occur of (i) the Company’s Initial Public Offering, (ii) the date on which this Agreement is terminated by a writing executed by holders of at least fifty percent (50%) of the shares of
Preferred Stock (voting together as a single class) then held by the Investors, (iii) the dissolution or winding-up of the Company, or (iv) immediately prior to the effective date of a Change of
Control. 
 Section 4 

Right of First Refusal 

4.1 Right of First Refusal. The Company hereby grants to each Preferred Holder the right of first refusal to purchase its pro rata
share of New Securities (as defined in Section 4.1(a)) which the Company may, from time to time, propose to sell and issue after the date of this Agreement. A Preferred Holder’s pro rata share, for purposes of
Section 4, is equal to the ratio of (a) the number of shares of Common Stock owned by such Preferred Holder immediately prior to the issuance of New Securities (assuming full conversion of the

  
 -16- 

 
Shares and exercise of all outstanding convertible securities, rights, options and warrants, directly or indirectly, into Common Stock held by said Preferred Holder) to (b) the total number
of shares of Common Stock outstanding immediately prior to the issuance of New Securities (assuming full conversion of the Shares and exercise of all outstanding convertible securities, rights, options and warrants, directly or indirectly, held by
all Preferred Holders). 
 (a) “New Securities” shall mean any capital stock (including Common Stock and/or Preferred Stock)
of the Company whether now authorized or not, and rights, convertible securities, options or warrants to purchase such capital stock, and securities of any type whatsoever that are, or may become, exercisable or convertible into capital stock;
provided that the term “New Securities” does not include: 
 (i) the Shares and Registrable Securities; 

(ii) any shares of Series 5 Preferred Stock issued pursuant to the Series 5 Purchase Agreement, any shares of Common Stock issued upon
conversion of any shares of Series 5 Preferred Stock issued pursuant to the Series 5 Purchase Agreement; 
 (iii) any shares of Common Stock
issued upon conversion of any shares of Series 4 Preferred Stock issued pursuant to the Series 4 Purchase Agreement, any warrants to purchase shares of Series 4 Preferred Stock issued pursuant to the Series 4 Purchase Agreement, any shares of Series
4 Preferred Stock or Common Stock issuable upon conversion or exercise of any such warrants, any shares of Common Stock issuable upon conversion of any shares of Series 4 Preferred Stock issued upon conversion or exercise of such warrants, any
warrants to purchase shares of Common Stock issued pursuant to the Series 3 Purchase Agreement, any shares of Common Stock issuable upon conversion or exercise of any such warrants; 

(iv) shares of Common Stock issued or issuable to officers, directors and employees of, or consultants to, the Company pursuant to any stock
option plan approved by the Board of Directors; 
 (v) securities issued pursuant to the conversion or exercise of any securities that are
convertible into or exercisable for Common Stock or Preferred Stock outstanding as of the date of this Agreement; 
 (vi) shares of Common
Stock issued or issuable as a dividend or distribution on any series of Preferred Stock or pursuant to any event for which adjustment is made pursuant to Article FOURTH, Subsections 4(e), 4(f), 4(g) or and 4(h) of the Amended and Restated
Certificate of Incorporation of the Company; 
 (vii) securities offered pursuant to an Initial Public Offering; 

(viii) shares of Common Stock issued or issuable pursuant to the acquisition of another corporation by the Company by merger, purchase of
substantially all of the assets or other reorganization, the principal purpose of which is other than raising capital through the sale of equity securities of the Company, provided, that such issuances are approved by the Board of Directors of the
Company; 
 (ix) shares of Common Stock issued or issuable to banks, equipment lessors, landlords or other financial institutions pursuant
to a commercial leasing (including, but not limited to equipment and/or real estate) or debt financing transaction, the principal purpose of which is other than raising capital through the sale of equity securities of the Corporation, provided, that
such issuances are approved by the Board of Directors of the Company; 

  
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 (x) shares of Common Stock issued or issuable in connection with sponsored research,
collaboration, technology license, development, OEM, marketing or other similar agreements, or strategic partnerships or arrangements approved by the Board of Directors of the Company; 

(xi) shares of Common Stock issued to suppliers or third party service providers in connection with the provision of goods or services
pursuant to transactions approved by the Board of Directors of the Company; 
 (xii) securities of the Company which are otherwise excluded
by the affirmative vote or consent of the holders of a majority of the shares of Preferred Stock of the Company then outstanding, voting together as a single class on an as converted basis; 

(xiii) any right, option or warrant to acquire any security convertible into the securities excluded from the definition of New Securities
pursuant to subsections (i) through (xii) above; and 
 (xiv) any shares of Common Stock issuable upon conversion of the Preferred
Stock pursuant to Article FOURTH Subsection 4(c) of the Amended and Restated Certificate of Incorporation. 
 (b) In the event the Company
proposes to undertake an issuance of New Securities, it shall give each Preferred Holder written notice of its intention, describing the type of New Securities, and their price and the general terms upon which the Company proposes to issue the same.
Each Preferred Holder shall have ten (10) days after any such notice is mailed or delivered to agree to purchase such Preferred Holder’s pro rata share of such New Securities for the price and upon the terms specified in the notice by
giving written notice to the Company and stating therein the quantity of New Securities to be purchased. 
 (c) In the event the Preferred
Holders fail to exercise fully the right of first refusal within said ten (10) day period (the “Election Period”), the Company shall have ninety (90) days thereafter to sell or enter into an agreement (pursuant to which
the sale of New Securities covered thereby shall be closed, if at all, within ninety (90) days from the date of said agreement) to sell that portion of the New Securities with respect to which the Preferred Holders’ right of first refusal
option set forth in this Section 4.1 was not exercised, at a price and upon terms no more favorable to the purchasers thereof than specified in the Company’s notice to the Preferred Holders delivered pursuant to
Section 4.1(b). In the event the Company has not sold within the later of such ninety (90) day period following the end of the Election Period, or such ninety (90) day period following the date of said agreement,
the Company shall not thereafter issue or sell any New Securities, without first again offering such securities to the Preferred Holders in the manner provided in this Section 4.1. 

(d) The right of first refusal granted under this Agreement shall expire upon, and shall not be applicable to, the Company’s Initial
Public Offering. 
 Section 5 

Miscellaneous 
 5.1
Amendment. Except as expressly provided herein, neither this Agreement nor any term hereof may be amended, waived, discharged or terminated other than by a written instrument referencing this Agreement and signed by the Company and the
Holders holding at least a majority of the shares of Registrable Securities (excluding any of such shares that have been sold to the public or pursuant to Rule 144); provided, however, that any amendment, waiver, discharge or termination that
adversely affects the rights of Holders of a particular series of Preferred Stock or Common Stock under this Agreement in a materially different manner than it affects the rights of the Holders of all series of Preferred Stock or Common Stock under
this Agreement shall require the prior written consent of Holders of at least a majority of the shares of such adversely affected series or class. Notwithstanding the foregoing, Holders purchasing shares of Series 5 Preferred Stock after the

  
 -18- 

 
date of this Agreement may become parties to this Agreement, by executing a counterpart of this Agreement without any amendment of this Agreement pursuant to this paragraph or any consent or
approval of any other Holder. Any such amendment, waiver, discharge or termination effected in accordance with this paragraph shall be binding upon each Holder and each future holder of all such securities of Holder. Each Holder acknowledges that by
the operation of this paragraph, the holders of a majority of shares of Registrable Securities (excluding any of such shares that have been sold to the public or pursuant to Rule 144) will have the right and power to diminish or eliminate all rights
of such Holder under this Agreement. 
 5.2 Notices. All notices and other communications required or permitted hereunder shall be in
writing and shall be mailed by registered or certified mail, postage prepaid, sent by facsimile or electronic mail or otherwise delivered by hand or by messenger addressed: 

(a) if to any holder of the capital stock of the Company at such holder’s address, facsimile number or electronic mail address as shown in
the Company’s records, as may be updated in accordance with the provisions hereof; 
 (b) if to any Holder, at such address, facsimile
number or electronic mail address as shown in the Company’s records, or, until any such holder so furnishes an address, facsimile number or electronic mail address to the Company, then to and at the address of the last holder of such shares for
which the Company has contact information in its records; or 
 (c) if to the Company, one copy should be sent to Attn: Chief Executive
Officer, 2900 Lakeside Drive, #160, Santa Clara, CA 95054, fax number: (650) 964-8911, or at such other address as the Company shall have furnished to the Investors, with a copy (which shall not constitute
notice) to Mark Weeks, Cooley LLP, 3175 Hanover St, Palo Alto, CA 94304, fax number (650) 849-7400, electronic mail address: mweeks@cooley.com; or 

Each such notice or other communication shall for all purposes of this Agreement be treated as effective or having been given when delivered
if delivered personally, or, if sent by mail, at the earlier of its receipt or seventy-two (72) hours after the same has been deposited in a regularly maintained receptacle for the deposit of the United
States mail, addressed and mailed as aforesaid or, if sent by fax, upon confirmation of fax transfer or, if sent by electronic mail, upon confirmation of delivery when directed to the e- mail address set forth
on the Schedule of Investors. 
 5.3 Governing Law. This Agreement and all acts and transactions pursuant hereto and the rights and
obligations of the parties hereto shall be governed, construed and interpreted in all respects in accordance with the General Corporation Law of the State of Delaware as to matters governed by such General Corporation Law, and as to all other
matters in accordance with the laws of the State of Delaware without regard to its choice of laws principles. 
 5.4 Successors and
Assigns. Except as provided in Section 2.8, this Agreement, and any and all rights, duties and obligations hereunder, shall not be assigned, transferred, delegated or sublicensed by any Holder without the prior written
consent of the Company. Any attempt by a Holder without such permission to assign, transfer, delegate or sublicense any rights, duties or obligations that arise under this Agreement shall be void. Subject to the foregoing and except as otherwise
provided herein, the provisions of this Agreement shall inure to the benefit of, and be binding upon, the successors, assigns, heirs, executors and administrators of the parties hereto. 

5.5 Entire Agreement. This Agreement and the exhibits hereto constitute the full and entire understanding and agreement between the
parties with regard to the subjects hereof. No party hereto shall be liable or bound to any other party in any manner with regard to the subjects hereof or thereof by any warranties, representations or covenants except as specifically set forth
herein. 

  
 -19- 

 5.6 Delays or Omissions. Except as expressly provided herein, no delay or omission to
exercise any right, power or remedy accruing to any party to this Agreement upon any breach or default of any other party under this Agreement shall impair any such right, power or remedy of such
non-defaulting party, nor shall it be construed to be a waiver of any such breach or default, or an acquiescence therein, or of or in any similar breach or default thereafter occurring, nor shall any waiver of
any single breach or default be deemed a waiver of any other breach or default theretofore or thereafter occurring. Any waiver, permit, consent or approval of any kind or character on the part of any party of any breach or default under this
Agreement, or any waiver on the part of any party of any provisions or conditions of this Agreement, must be in writing and shall be effective only to the extent specifically set forth in such writing. All remedies, either under this Agreement or by
law or otherwise afforded to any party to this Agreement, shall be cumulative and not alternative. 
 5.7 Severability. If one or more
provisions of this Agreement are held to be unenforceable under applicable law, the parties agree to renegotiate such provision in good faith so as to effect the original intent of the parties as closely as possible in an acceptable manner in order
that the transactions contemplated hereby are consummated as originally contemplated to the greatest extent possible. In the event that the parties cannot reach a mutually agreeable and enforceable replacement for such provision, then (a) such
provision shall be excluded from this Agreement, (b) the balance of the Agreement shall be interpreted as if such provision were so excluded and (c) the balance of the Agreement shall be enforceable in accordance with its terms; provided
that no such severability shall be effective if it materially changes the economic benefit of this Agreement to any party or deprive such party of its essential bargain hereunder. 

5.8 Titles and Subtitles. The titles and subtitles used in this Agreement are used for convenience only and are not to be considered in
construing or interpreting this Agreement. All references in this Agreement to sections, paragraphs and exhibits shall, unless otherwise provided, refer to sections and paragraphs hereof and exhibits attached hereto. 

5.9 Counterparts. This Agreement may be executed in any number of counterparts, each of which shall be enforceable against the parties
that execute such counterparts, and all of which together shall constitute one instrument. This Agreement may also be executed and delivered by facsimile signature, PDF or any electronic signature complying with the U.S. federal ESIGN Act of 2000
(e.g., www.docusign.com). Such execution and delivery shall be considered valid, binding and effective for all purposes. At the request of any party hereto, all parties hereto agree to execute and deliver an original of this Agreement as well as any
facsimile, telecopy or other reproduction hereof. 
 5.10 Jurisdiction; Venue. With respect to any disputes arising out of or related
to this Agreement, the parties consent to the sole and exclusive jurisdiction of, and venue in, the state courts in Santa Clara County in the State of California (or in the event of sole and exclusive federal jurisdiction, the courts of the Northern
District of California). 
 5.11 Further Assurances. Each party hereto agrees to execute and deliver, by the proper exercise of its
corporate, limited liability company, partnership or other powers, all such other and additional instruments and documents and do all such other acts and things as may be reasonably necessary to more fully effectuate this Agreement. 

  
 -20- 

 5.12 Attorneys’ Fees. In the event that any suit or action is
instituted to enforce any provision in this Agreement, the prevailing party in such dispute shall be entitled to recover from the losing party such reasonable fees and expenses of attorneys and accountants, which shall include, without limitation,
all fees, costs and expenses of appeals. 
 5.13 Amendment and Restatement of the Prior Rights Agreement. By execution of this
Agreement, the Company and the undersigned Holders hereby amend and restate the Prior Rights Agreement as set forth herein. 

(Signature Page Follows) 

  
 -21- 

 IN WITNESS WHEREOF, the parties hereto have executed this Eighth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

			
	COMPANY:
	
	 CARDIVA MEDICAL, INC.
 a
Delaware corporation

		
	By:	 	 /s/ John Russell

	Name:	 	John Russell
	Title:	 	CEO

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Eighth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

	
	HOLDER:
	
	 /s/ Matthew Crawford

	(Signature)
	
	PTV SCIENCES II, L.P.
	By: Pinto Technology Ventures GP II, LP, its General Partner
	By: Pinto TV GP Company LLC, Its General
	 Partner

	(Name of Holder)
	
	 Matthew Crawford, Manager

	(Name and Title of Signatory, if Applicable)

  

	
	 /s/ Rick Anderson

	(Signature)
	
	PTV IV, L.P.
	By: PTV GP IV L.P., its General Partner
	 By: PTV GP III Management LLC, its General Partner

	(Name of Holder)
	
	 Rick Anderson, Manager

	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 
	
	HOLDER:
	
	 /s/ Francisco F. Rodriguez

	(Signature)
	
	 RIND, LTD.

	(Name of Holder)
	
	 Francisco F. Rodriguez, Director

	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 
	
	HOLDER:
	
	 /s/ George J. Lee

	(Signature)
	
	 AMKEY BIOTECHNOLOGY VENTURE CAPITAL, INC.

	(Name of Holder)
	
	 George J. Lee, Director

	(Name and Title of Signatory, if Applicable)
	
	 /s/ George J. Lee

	(Signature)
	
	 AMKEY VENTURE CAPITAL, INC.

	(Name of Holder)
	
	 George J. Lee, Director

	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Eighth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

	
	HOLDER:
	
	 /s/ George J. Lee

	(Signature)
	
	 GEORGE J. LEE

	(Name of Holder)
	
	 N/A

	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Eighth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

	
	HOLDER:
	
	 /s/ TS Chen

	(Signature)
	
	 BIO INTECH, LTD

	(Name of Holder)
	
	 TS Chen, Partner

	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 
	
	HOLDER:
	
	 /s/ Chien-Chun Chang

	(Signature)
	
	 CHIEN-CHUN CHANG

	(Name of Holder)
	
	 N/A

	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Eighth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

	
	HOLDER:
	
	 /s/ Mein Kai Chang

	(Signature)
	
	 MEIN KAI CHANG

	(Name of Holder)
	
	 N/A

	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 
	
	HOLDER:
	
	 /s/ Tony Fon-Lein Chang

	(Signature)
	
	 TONY FON-LEIN CHANG

	(Name of Holder)
	
	 N/A

	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 
	
	HOLDER:
	
	 /s/ David Conklin

	(Signature)
	
	 DAVID P. AND WENDY CONKLIN

	(Name of Holder)
	
	 N/A

	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 
	
	HOLDER:
	
	 /s/ Chen Wen Han

	(Signature)
	
	 CROWN INVESTMENT WORLDWIDE, LTD.

	(Name of Holder)
	
	 Chen Wen Han C.E.O.

	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 
	
	HOLDER:
	
	 /s/ George J. Lee

	(Signature)
	
	 EUREKA BIOVENTURE PARTNERS

	(Name of Holder)
	
	 George J. Lee, General Partner

	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Eighth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

	
	HOLDER:
	
	 /s/ Fu Den Nan

	(Signature)
	
	 FU DEN NAN (WILLIAM FU)

	(Name of Holder)
	
	 N/A

	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 
	
	HOLDER:
	
	 /s/ Chang Liao Chuan

	(Signature)
	
	 GLOBAL STAR INTERNATIONAL CO., LTD

	(Name of Holder)
	
	 Chang Liao Chuan

	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 
	
	HOLDER:
	
	 /s/ Jyan Ming Yan

	(Signature)
	
	 HERCULES BIOVENTURE, L.P.

	(Name of Holder)
	
	 Jyan Ming Yan, General Partner

	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 
	
	HOLDER:
	
	 /s/ Michael J. Horgan

	(Signature)
	
	 MICHAEL J. HORGAN

	(Name of Holder)
	
	 N/A

	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 
	
	HOLDER:
	
	 /s/ Fu-Lung Hsu

	(Signature)
	
	 JACK INVESTMENT CO., LTD.

	(Name of Holder)
	
	 Fu-Lung Hsu, CEO

	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 
	
	HOLDER:
	
	 /s/ Mark Klopp

	(Signature)
	
	 MARK V. KLOPP

	(Name of Holder)
	
	 N/A

	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 
	
	HOLDER:
	
	 /s/ George J. Lee

	(Signature)
	
	 GEORGE J. LEE, PH.D.

	(Name of Holder)
	
	 N/A

	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 
	
	HOLDER:
	
	 /s/ Maw Sheng Lee

	(Signature)
	
	 MAW SHENG LEE

	(Name of Holder)
	
	 N/A

	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 
	
	HOLDER:
	
	 /s/ George J. Lee

	(Signature)
	
	 LEXLI INVESTMENT, LLC

	(Name of Holder)
	
	 George J. Lee, Partner

	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 
	
	HOLDER:
	
	 /s/ Sylvia Liu

	(Signature)
	
	 SYLVIA LIU

	(Name of Holder)
	
	 David Lichtenstein, on behalf of Ms. Sylvia Liu

	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Eighth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

	
	HOLDER:
	
	 /s/ Charles T. Maroney

	(Signature)
	
	 CHARLES T. MARONEY

	(Name of Holder)
	
	 N/A

	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Eighth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

	
	HOLDER:
	
	 /s/ Jerry Chiou

	(Signature)
	
	 NCKU VENTURE CAPITAL CO., LTD.

	(Name of Holder)
	
	 Jerry Chiou, President

	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Eighth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

	
	HOLDER:
	
	 /s/ Shang Te Chan

	(Signature)
	
	 REDPINE FINANCE HOLDINGS, INC.

	(Name of Holder)
	
	 Shang Te Chan, Authorized Signatory

	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Eighth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

	
	HOLDER:
	
	 /s/ Chun-Chien Shih

	(Signature)
	
	 CHUN-CHIEN SHIH

	(Name of Holder)
	
	 N/A

	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 
	
	HOLDER:
	
	 /s/ Jerry Shih

	(Signature)
	
	 JERRY SHIH

	(Name of Holder)
	
	 N/A

	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 
	
	HOLDER:
	
	 /s/ Augustine Lien

	(Signature)
	
	 THE LIEN FAMILY LIVING TRUST, DATED MARCH 5, 2003

	(Name of Holder)
	
	 Augustine Lien / Trustee

	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Eighth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

	
	HOLDER:
	
	 /s/ Shang Te Chang

	(Signature)
	
	 TSC BIOVENTURE CAPITAL

CORPORATION

	(Name of Holder)
	
	 Shang Te Chang, President

	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 
	
	HOLDER:
	
	 /s/ Shih Mei Ma

	(Signature)
	
	 UNIVERSAL MIGRATION LTD.

	(Name of Holder)
	
	 Shih Mei Ma, Managing Director

	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

	
	HOLDER:
	
	/s/ Craig M. Walker
	(Signature)
	
	 CRAIG M. WALKER, MD

	(Name of Holder)
	
	 N/A

	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 
	
	HOLDER:
	
	 /s/ Jonas Chia-Tsun Wang

	(Signature)
	
	 JONAS CHIA-TSUN WANG

	(Name of Holder)
	
	 N/A

	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Eighth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

	
	HOLDER:
	
	 /s/ Michael D. Bornitz

	(Signature)
	
	 301 CARDIVA PARTNERS, LLC

	(Name of Holder)
	
	 Michael D. Bornitz, Manager

	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

EIGHTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 EXHIBIT A 

SECURITYHOLDERS 
 AmKey
Biotechnology Venture Capital, Inc. 
 AmKey Venture Capital, Inc. 

Bio Intech Ltd. 
 Chien-Chun Chang

 Chang Mein Kai 
 Tony Fon-Lein Chang 
 Yu San Elyn Chang 

Stephen Sun Chiao 
 David P. and
Wendy Conklin 
 Crown Investment Worldwide, Ltd. 

Michael A. Daniel 
 Der Yang
Biotechnology Venture Capital Co., ltd. 
 Eminent Venture Capital Corporation 

Eureka BioVenture Partners 
 Fu Den
Nan (William Fu) 
 Global Assets Investment, LLC 

Global Star International Co., Ltd. 

Hercules Bioventure, L.P. 
 Hanako
Hiramatsu 
 Michael J. Horgan 

Jack Investment Co., Ltd. 
 Mark V.
Klopp 
 George J. Lee, Ph.D. 

Maw Sheng Lee 
 Lexli Investment,
LLC 
 The Lien Family Trust, Dated March 5, 2003 

Sylvia Liu 
 Charles T. Maroney 

Frederic H. Moll 
 NCKU Venture
Capital Co., Ltd. 
 PTV Sciences II, L.P. 

Redpine Finance Holdings, Inc. 

Rind, Ltd. 
 Chun-Chien Shih 

Jerry Shih 
 Kilin To 

Dean & Ping Tsao Family Limited Partnership No. 2, LP 

TSC BioVenture Capital Corporation 

Universal Migration Ltd. 
 Craig M.
Walker, M.D. 
 Jonas Chia-Tsun Wang 

PTV IV, L.P. 
 301 Cardiva Partners,
LLC 
 Canepa Advanced Healthcare Fund, L.P.EX-10.2

 Exhibit 10.2 

CARDIVA MEDICAL, INC. 

2002 STOCK OPTION PLAN 

Adopted by the Board of Directors: November 12, 2002 

Approved by Shareholders: November 12, 2002 

Termination Date: November 12, 2012 

As Amended: April 19, 2008 

1. Purposes of the Plan. The purposes of this Stock Option Plan are to attract and retain the best available personnel for positions of
substantial responsibility, to provide additional incentive to Employees, Directors and Consultants and to promote the success of the Company business. Options granted under the Plan may be Incentive Stock Options or Nonstatutory Stock Options, as
determined by the Administrator at the time of grant. 
 2. Definitions. As used herein, the following definitions shall apply: 

(a) “Administrator” means the Board or any of its Committees as shall be administering the Plan in accordance with
Section 4 hereof. 
 (b) “Applicable Laws” means the requirements relating to the administration of stock option plans
under U.S. state corporate laws, U.S. federal and state securities laws, the Code, any stock exchange or quotation system on which the Common Stock is listed or quoted and the applicable laws of any other country or jurisdiction where Options are
granted under the Plan. 
 (c) “Board” means the Board of Directors of the Company. 

(d) “Change in Control” means the occurrence of any of the following events: 

(i) Any “person” (as such term is used in Sections 13(d) and 14(d) of the Exchange Act) becomes the “beneficial owner” (as
defined in Rule 13d-3 of the Exchange Act), directly or indirectly, of securities of the Company representing fifty percent (50%) or more of the total voting power represented by the Company’s then
outstanding voting securities; or 
 (ii) The consummation of the sale or disposition by the Company of all or substantially all of the
Company’s assets; or 
 (iii) The consummation of a merger or consolidation of the Company with any other corporation, other than a
merger or consolidation which would result in the voting securities of the Company outstanding immediately prior thereto continuing to represent (either by remaining outstanding or by being converted into voting securities of the surviving entity or
its parent) at least fifty percent (50%) of the total voting power represented by the voting securities of the Company or such surviving entity or its parent outstanding immediately after such merger or consolidation. 

(e) “Code” means the Internal Revenue Code of 1986, as amended. 

(f) “Committee” means a committee of Directors appointed by the Board in accordance with Section 4 hereof. 

(g) “Common Stock” means the Common Stock of the Company. 

(h) “Company” means Cardiva Medical, Inc., a California corporation. 

(i) “Consultant” means any natural person who is engaged by the Company or any Parent or Subsidiary to render consulting or
advisory services to such entity and who satisfies the requirements of subsection (c)(1) of Rule 701 under the Securities Act of 1933, as amended. 

  
 1. 

 (j) “Director” means a member of the Board. 

(k) “Disability” means total and permanent disability as defined in Section 22(e)(3) of the Code. 

(l) “Employee” means any person, including officers and Directors, employed by the Company or any Parent or Subsidiary of the
Company. A Service Provider shall not cease to be an Employee in the case of (i) any leave of absence approved by the Company or (ii) transfers between locations of the Company or between the Company, its Parent, any Subsidiary, or any
successor. For purposes of Incentive Stock Options, no such leave may exceed ninety (90) days, unless reemployment upon expiration of such leave is guaranteed by statute or contract. If reemployment upon expiration of a leave of absence
approved by the Company is not so guaranteed, then three (3) months following the ninety-first (91st) day of such leave, any Incentive Stock Option held by the Optionee shall cease to be
treated as an Incentive Stock Option and shall be treated for tax purposes as a Nonstatutory Stock Option. Neither service as a Director nor payment of a director’s fee by the Company shall be sufficient to constitute “employment” by
the Company. 
 (m) “Exchange Act” means the Securities Exchange Act of 1934, as amended. 

(n) “Fair Market Value” means, as of any date, the value of Common Stock determined as follows: 

(i) If the Common Stock is listed on any established stock exchange or a national market system, including without limitation the Nasdaq
National Market or The Nasdaq SmallCap Market of The Nasdaq Stock Market, its Fair Market Value shall be the closing sales price for such stock (or the closing bid, if no sales were reported) as quoted on such exchange or system on the day of
determination, as reported in The Wall Street Journal or such other source as the Administrator deems reliable; 
 (ii) If the Common
Stock is regularly quoted by a recognized securities dealer but selling prices are not reported, its Fair Market Value shall be the mean between the high bid and low asked prices for the Common Stock on the day of determination; or 

(iii) In the absence of an established market for the Common Stock, the Fair Market Value thereof shall be determined in good faith by the
Administrator. 
 (o) “Incentive Stock Option” means an Option intended to qualify as an incentive stock option within the
meaning of Section 422 of the Code. 
 (p) “Nonstatutory Stock Option” means an Option not intended to qualify as an
Incentive Stock Option. 
 (q) “Option” means a stock option granted pursuant to the Plan. 

(r) “Option Agreement” means a written or electronic agreement between the Company and an Optionee evidencing the terms and
conditions of an individual Option grant. The Option Agreement is subject to the terms and conditions of the Plan. 
 (s) “Optioned
Stock” means the Common Stock subject to an Option. 
 (t) “Optionee” means the holder of an outstanding Option
granted under the Plan. 
 (u) “Parent” means a “parent corporation,” whether now or hereafter existing, as
defined in Section 424(e) of the Code. 
 (v) “Plan” means this 2002 Stock Option Plan. 

  
 2. 

 (w) “Service Provider” means an Employee, Director or Consultant. 

(x) “Share” means a share of the Common Stock, as adjusted in accordance with Section 12 below. 

(y) “Subsidiary” means a “subsidiary corporation,” whether now or hereafter existing, as defined in
Section 424(f) of the Code. 
 3. Stock Subject to the Plan. Subject to the provisions of Section 12 of the Plan, the
maximum aggregate number of Shares that may be subject to option and sold under the Plan is five million nine hundred seventy-one thousand forty (5,971,040) Shares. The Shares may be authorized but unissued,
or reacquired Common Stock. 
 If an Option expires or becomes unexercisable without having been exercised in full, the unpurchased Shares
which were subject thereto shall become available for future grant or sale under the Plan (unless the Plan has terminated). However, Shares that have actually been issued under the Plan, upon exercise of an Option, shall not be returned to the Plan
and shall not become available for future distribution under the Plan, except that if Shares of restricted stock issued pursuant to an Option are repurchased by the Company at their original purchase price, such Shares shall become available for
future grant under the Plan. 
 4. Administration of the Plan. 

(a) Administrator. The Plan shall be administered by the Board or a Committee appointed by the Board, which Committee shall be
constituted to comply with Applicable Laws. 
 (b) Powers of the Administrator. Subject to the provisions of the Plan and, in the case
of a Committee, the specific duties delegated by the Board to such Committee, and subject to the approval of any relevant authorities, the Administrator shall have the authority in its discretion: 

(i) to determine the Fair Market Value; 

(ii) to select the Service Providers to whom Options may from time to time be granted hereunder; 

(iii) to determine the number of Shares to be covered by each such Option granted hereunder; 

(iv) to approve forms of agreement for use under the Plan; 

(v) to determine the terms and conditions of any Option granted hereunder. Such terms and conditions include, but are not limited to, the
exercise price, the time or times when Options may be exercised (which may be based on performance criteria), any vesting acceleration or waiver of forfeiture restrictions, and any restriction or limitation regarding any Option or the Common Stock
relating thereto, based in each case on such factors as the Administrator, in its sole discretion, shall determine; 
 (vi) to prescribe,
amend and rescind rules and regulations relating to the Plan, including rules and regulations relating to sub-plans established for the purpose of satisfying applicable foreign laws; 

(vii) to allow Optionees to satisfy withholding tax obligations by electing to have the Company withhold from the Shares to be issued upon
exercise of an Option that number of Shares having a Fair Market Value equal to the minimum amount required to be withheld. The Fair Market Value of the Shares to be withheld shall be determined on the date that the amount of tax to be withheld is
to be determined. All elections by Optionees to have Shares withheld for this purpose shall be made in such form and under such conditions as the Administrator may deem necessary or advisable; and 

  
 3. 

 (viii) to construe and interpret the terms of the Plan and Options granted pursuant to the
Plan. 
 (c) Effect of Administrator’s Decision. All decisions, determinations and interpretations of the Administrator shall be final
and binding on all Optionees. 
 5. Eligibility. Nonstatutory Stock Options may be granted to Service Providers. Incentive Stock
Options may be granted only to Employees. 
 6. Limitations. 

(a) Incentive Stock Option Limit. Each Option shall be designated in the Option Agreement as either an Incentive Stock Option or a
Nonstatutory Stock Option. However, notwithstanding such designation, to the extent that the aggregate Fair Market Value of the Shares with respect to which Incentive Stock Options are exercisable for the first time by the Optionee during any
calendar year (under all plans of the Company and any Parent or Subsidiary) exceeds $100,000, such Options shall be treated as Nonstatutory Stock Options. For purposes of this Section 6(a), Incentive Stock Options shall be taken into account in
the order in which they were granted. The Fair Market Value of the Shares shall be determined as of the time the Option with respect to such Shares is granted. 

(b) At-Will Employment. Neither the Plan nor any Option shall confer upon any Optionee any right
with respect to continuing the Optionee’s relationship as a Service Provider with the Company, nor shall it interfere in any way with his or her right or the Company’s right to terminate such relationship at any time, with or without
cause, and with or without notice. 
 7. Term of Plan. Subject to shareholder approval in accordance with Section 18, the Plan
shall become effective upon its adoption by the Board. Unless sooner terminated under Section 14, it shall continue in effect for a term of ten (10) years from the later of (i) the effective date of the Plan, or (ii) the date of
the most recent Board approval of an increase in the number of shares reserved for issuance under the Plan. 
 8. Term of Option. The
term of each Option shall be stated in the Option Agreement; provided, however, that the term shall be no more than ten (10) years from the date of grant thereof. In the case of an Incentive Stock Option granted to an Optionee who, at the time
the Option is granted, owns stock representing more than ten percent (10%) of the voting power of all classes of stock of the Company or any Parent or Subsidiary, the term of the Option shall be five (5) years from the date of grant or such
shorter term as may be provided in the Option Agreement. 
 9. Option Exercise Price and Consideration. 

(a) Exercise Price. The per share exercise price for the Shares to be issued upon exercise of an Option shall be such price as is
determined by the Administrator, but shall be subject to the following: 
 (i) In the case of an Incentive Stock Option 

(A) granted to an Employee who, at the time of grant of such Option, owns stock representing more than ten percent (10%) of the voting power
of all classes of stock of the Company or any Parent or Subsidiary, the exercise price shall be no less than one hundred ten percent (110%) of the Fair Market Value per Share on the date of grant. 

(B) granted to any other Employee, the per Share exercise price shall be no less than 100% of the Fair Market Value per Share on the date of
grant. 

  
 4. 

 (ii) In the case of a Nonstatutory Stock Option 

(A) granted to a Service Provider who, at the time of grant of such Option, owns stock representing more than ten percent (10%) of the voting
power of all classes of stock of the Company or any Parent or Subsidiary, the exercise price shall be no less than one hundred ten percent (110%) of the Fair Market Value per Share on the date of grant. 

(B) granted to any other Service Provider, the per Share exercise price shall be no less than eighty-five percent (85%) of the Fair Market
Value per Share on the date of grant. 
 (iii) Notwithstanding the foregoing, Options may be granted with a per Share exercise price other
than as required above pursuant to a merger or other corporate transaction. 
 (b) Forms of Consideration. The consideration to be
paid for the Shares to be issued upon exercise of an Option, including the method of payment, shall be determined by the Administrator (and, in the case of an Incentive Stock Option, shall be determined at the time of grant). Such consideration may
consist of, without limitation, (1) cash, (2) check, (3) promissory note, (4) other Shares, provided Shares acquired directly from the Company (x) have been owned by the Optionee for more than six (6) months on the date of
surrender, and (y) have a Fair Market Value on the date of surrender equal to the aggregate exercise price of the Shares as to which such Option shall be exercised, (5) consideration received by the Company under a cashless exercise
program implemented by the Company in connection with the Plan, or (6) any combination of the foregoing methods of payment. In making its determination as to the type of consideration to accept, the Administrator shall consider if acceptance of
such consideration may be reasonably expected to benefit the Company. Notwithstanding the foregoing, the Administrator may permit an Optionee to exercise his or her Option by delivery of a full-recourse promissory note secured by the purchased
Shares. The terms of such promissory note shall be determined by the Administrator in its sole discretion. 
 10. Exercise of Option.

 (a) Procedure for Exercise; Rights as a Shareholder. Any Option granted hereunder shall be exercisable according to the terms
hereof at such times and under such conditions as determined by the Administrator and set forth in the Option Agreement. Except in the case of Options granted to officers, Directors and Consultants, Options shall become exercisable at a rate of no
less than twenty percent (20%) per year over five (5) years from the date the Options are granted. Unless the Administrator provides otherwise, vesting of Options granted hereunder to officers and Directors shall be suspended during any unpaid
leave of absence. An Option may not be exercised for a fraction of a Share. 
 An Option shall be deemed exercised when the Company receives
(i) written or electronic notice of exercise (in accordance with the Option Agreement) from the person entitled to exercise the Option, and (ii) full payment for the Shares with respect to which the Option is exercised. Full payment may
consist of any consideration and method of payment authorized by the Administrator and permitted by the Option Agreement and the Plan. Shares issued upon exercise of an Option shall be issued in the name of the Optionee or, if requested by the
Optionee, in the name of the Optionee and his or her spouse. Until the Shares are issued (as evidenced by the appropriate entry on the books of the Company or of a duly authorized transfer agent of the Company), no right to vote or receive dividends
or any other rights as a shareholder shall exist with respect to the Shares, notwithstanding the exercise of the Option. The Company shall issue (or cause to be issued) such Shares promptly after the Option is exercised. No adjustment will be made
for a dividend or other right for which the record date is prior to the date the Shares are issued, except as provided in Section 12 of the Plan. 

Exercise of an Option in any manner shall result in a decrease in the number of Shares thereafter available, both for purposes of the Plan and
for sale under the Option, by the number of Shares as to which the Option is exercised. 
 (b) Termination of Relationship as a Service
Provider. If an Optionee ceases to be a Service Provider, such Optionee may exercise his or her Option within thirty (30) days of termination, or such longer period of time as specified in the Option Agreement, to the extent that the Option
is vested on the date of termination (but in no event later than the expiration of the term of the Option as set forth in the Option Agreement). If, on the date of termination, the Optionee is not vested as to his or her entire Option, the Shares
covered by the unvested portion of the Option shall revert to the Plan. If, after termination, the Optionee does not exercise his or her Option within the time specified by the Administrator, the Option shall terminate, and the Shares covered by
such Option shall revert to the Plan. 

  
 5. 

 (c) Disability of Optionee. If an Optionee ceases to be a Service Provider as a
result of the Optionee’s Disability, the Optionee may exercise his or her Option within six (6) months of termination, or such longer period of time as specified in the Option Agreement, to the extent the Option is vested on the date of
termination (but in no event later than the expiration of the term of such Option as set forth in the Option Agreement). If, on the date of termination, the Optionee is not vested as to his or her entire Option, the Shares covered by the unvested
portion of the Option shall revert to the Plan. If, after termination, the Optionee does not exercise his or her Option within the time specified herein, the Option shall terminate, and the Shares covered by such Option shall revert to the Plan.

 (d) Death of Optionee. If an Optionee dies while a Service Provider, the Option may be exercised within six (6) months
following Optionee’s death, or such longer period of time as specified in the Option Agreement, to the extent that the Option is vested on the date of death (but in no event later than the expiration of the term of such Option as set forth in
the Option Agreement) by the Optionee’s designated beneficiary, provided such beneficiary has been designated prior to Optionee’s death in a form acceptable to the Administrator. If no such beneficiary has been designated by the Optionee,
then such Option may be exercised by the personal representative of the Optionee’s estate or by the person(s) to whom the Option is transferred pursuant to the Optionee’s will or in accordance with the laws of descent and distribution. If,
at the time of death, the Optionee is not vested as to his or her entire Option, the Shares covered by the unvested portion of the Option shall immediately revert to the Plan. If the Option is not so exercised within the time specified herein, the
Option shall terminate, and the Shares covered by such Option shall revert to the Plan. 
 11. Limited Transferability of Options.
Unless determined otherwise by the Administrator, Options may not be sold, pledged, assigned, hypothecated, transferred, or disposed of in any manner other than by will or the laws of descent and distribution, and may be exercised during the
lifetime of the Optionee, only by the Optionee. If the Administrator in its sole discretion makes an Option transferable, such Option may only be transferred by (i) will, (ii) the laws of descent and distribution, (iii) instrument to an
inter vivos or testamentary trust in which the Option is to be passed to beneficiaries upon the death of the Optionee, or (iv) gift to a member of Optionee’s immediate family (as such term is defined in Rule
16a-1(e) of the Exchange Act). In addition, any transferable Option shall contain additional terms and conditions as the Administrator deems appropriate. 

12. Adjustments Upon Changes in Capitalization, Merger or Change in Control. 

(a) Changes in Capitalization. Subject to any required action by the shareholders of the Company, the number and type of Shares which
have been authorized for issuance under the Plan but as to which no Options have yet been granted or which have been returned to the Plan upon cancellation or expiration of an Option, and the number and type of Shares covered by each outstanding
Option, as well as the price per Share covered by each such outstanding Option, shall be proportionately adjusted for any increase or decrease in the number or type of issued Shares resulting from a stock split, reverse stock split, stock dividend,
combination or reclassification of the Common Stock, or any other increase or decrease in the number of issued shares of Common Stock effected without receipt of consideration by the Company. The conversion of any convertible securities of the
Company shall not be deemed to have been “effected without receipt of consideration.” Such adjustment shall be made by the Board, whose determination in that respect shall be final, binding and conclusive. Except as expressly
provided herein, no issuance by the Company of shares of stock of any class, or securities convertible into shares of stock of any class, shall affect, and no adjustment by reason thereof shall be made with respect to, the number, type or price of
Shares subject to an Option. 
 (b) Dissolution or Liquidation. In the event of the proposed dissolution or liquidation of the
Company, the Administrator shall notify each Optionee as soon as practicable prior to the effective date of such proposed transaction. The Administrator in its discretion may provide for an Optionee to have the right to exercise his or her Option
until fifteen (15) days prior to such transaction as to all of the Optioned Stock covered thereby, including Shares as to which the Option would not otherwise be exercisable. In addition, the Administrator may provide that any Company
repurchase option applicable to any Shares purchased upon exercise of an Option shall lapse as to all such Shares, provided the proposed dissolution or liquidation takes place at the time and in the manner contemplated. To the extent it has not been
previously exercised, an Option will terminate immediately prior to the consummation of such proposed action. 

  
 6. 

 (c) Merger or Change in Control. In the event of a merger of the Company with or into
another corporation, or a Change in Control, each outstanding Option shall be assumed or an equivalent option substituted by the successor corporation or a Parent or Subsidiary of the successor corporation. If, in such event, the Option is not
assumed or substituted, the Option shall terminate as of the date of the closing of the merger or Change in Control. For the purposes of this paragraph, the Option shall be considered assumed if, following the merger or Change in Control, the Option
confers the right to purchase or receive, for each Share of Optioned Stock subject to the Option immediately prior to the merger or Change in Control, the consideration (whether stock, cash, or other securities or property) received in the merger or
Change in Control by holders of Common Stock for each Share held on the effective date of the transaction (and if holders were offered a choice of consideration, the type of consideration chosen by the holders of a majority of the outstanding
Shares); provided, however, that if such consideration received in the merger or Change in Control is not solely common stock of the successor corporation or its Parent, the Administrator may, with the consent of the successor corporation, provide
for the consideration to be received upon the exercise of the Option, for each Share of Optioned Stock subject to the Option, to be solely common stock of the successor corporation or its Parent equal in fair market value to the per share
consideration received by holders of common stock in the merger or Change in Control. 
 13. Time of Granting Options. The date of
grant of an Option shall, for all purposes, be the date on which the Administrator makes the determination granting such Option, or such later date as is determined by the Administrator. Notice of the determination shall be given to each Service
Provider to whom an Option is so granted within a reasonable time after the date of such grant. 
 14. Amendment and Termination of the
Plan. 
 (a) Amendment and Termination. The Board may at any time amend, alter, suspend or terminate the Plan. 

(b) Shareholder Approval. The Board shall obtain shareholder approval of any Plan amendment to the extent necessary and desirable to
comply with Applicable Laws. 
 (c) Effect of Amendment or Termination. No amendment, alteration, suspension or termination of the
Plan shall impair the rights of any Optionee, unless mutually agreed otherwise between the Optionee and the Administrator, which agreement must be in writing and signed by the Optionee and the Company. Termination of the Plan shall not affect the
Administrator’s ability to exercise the powers granted to it hereunder with respect to Options granted under the Plan prior to the date of such termination. 

15. Conditions Upon Issuance of Shares. 

(a) Legal Compliance. Shares shall not be issued pursuant to the exercise of an Option unless the exercise of such Option and the
issuance and delivery of such Shares shall comply with Applicable Laws and shall be further subject to the approval of counsel for the Company with respect to such compliance. 

(b) Investment Representations. As a condition to the exercise of an Option, the Administrator may require the person exercising such
Option to represent and warrant at the time of any such exercise that the Shares are being purchased only for investment and without any present intention to sell or distribute such Shares if, in the opinion of counsel for the Company, such a
representation is required. 
 16. Inability to Obtain Authority. The inability of the Company to obtain authority from any regulatory
body having jurisdiction, which authority is deemed by the Company’s counsel to be necessary to the lawful issuance and sale of any Shares hereunder, shall relieve the Company of any liability in respect of the failure to issue or sell such
Shares as to which such requisite authority shall not have been obtained. 
 17. Reservation of Shares. The Company, during the term
of this Plan, shall at all times reserve and keep available such number of Shares as shall be sufficient to satisfy the requirements of the Plan. 

  
 7. 

 18. Shareholder Approval. The Plan shall be subject to approval by the shareholders
of the Company within twelve (12) months after the date the Plan is adopted. Such shareholder approval shall be obtained in the degree and manner required under Applicable Laws. 

19. Information to Optionees. The Company shall provide to each Optionee and to each individual who acquires Shares pursuant to the
Plan, not less frequently than annually during the period such Optionee has one (1) or more Options outstanding, and, in the case of an individual who acquires Shares pursuant to the Plan, during the period such individual owns such Shares,
copies of annual financial statements. The Company shall not be required to provide such statements to key employees whose duties in connection with the Company assure their access to equivalent information. 

  
 8.

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