Document:

<Page>

                                                                   Exhibit 10.16

[PICIS LOGO]                                Todd C. Cozzens
                                            President & CEO, Vice Chairman
                                            Tel: 781 557 3300 (direct)
                                            Fax: 781 557 3302
                                            Email: todd_cozzens@picis.com

June 16, 2006

Hon. Secretary Tommy G. Thompson
3101 N. Hampton Drive
Apartment 1611
Alexandria, VA  22302

Dear Secretary Thompson:

     This letter will confirm our understanding concerning your service as a
member of the Board of Directors (the "Board") of Picis, Inc. (the "Company")
and your engagement to provide certain services to the Company while you are
serving as a member of the Board.

     1.   TERM. Your tenure on the Board will commence upon your appointment to
the Board by the Board and/or the Company's stockholders and shall continue
thereafter until your resignation or removal or until your successor is duly
elected and qualified. We expect that you will be a member of the Board for at
least four years and that you will notify the Company at least six months before
resigning from the Board. You may also be asked to participate in one or more
committees of the Board, such as the Compensation Committee or the Audit
Committee.

     2.   COMPENSATION. In consideration of your services as a director of the
Company and your participation in each of the Board's regular quarterly meetings
and additionally called special meetings and conference calls, the Company will
pay you an annual Board fee of $15,000. You will receive an additional fee of
$2,000 for each meeting you attend in person and $1,000 for each meeting you
participate in by telephone. The annual fee for the first year of your term will
be prorated beginning with the effective date of your appointment and the annual
fee for your last year of service will be prorated through the date of
termination. If you are appointed to a Board committee, you will receive an
additional annual fee of $10,000 for services as a committee member (or $15,000
if you serve as committee chariman), as well as $500 for each committee meeting
you participate in by telephone or in person, except for committee meetings held
on the same day as full Board meetings. All the foregoing cash compensation will
be paid once a year following the annual meeting of shareholders.

     3.   EQUITY COMPENSATION. As additional consideration of your services as a
member of the Board, the Company will grant you 150,000 shares of restricted
stock. Your interest in such restricted stock shall vest based upon your length
of service on the Board, with 33% of such shares vesting as of the end of each
calendar year commencing December 31, 2006 so that your shares shall be fully
vested as of December 31, 2009, provided that you continue to serve on the
Board.

     4.   EXPENSES. The Company will pay or reimburse you for all authorized and
approved out-of-pocket expenses incurred in the course of your performance of
services pursuant to this Agreement in a manner consistent with the Company's
policies with respect to reimbursement of such expenses for its Board members
generally.

     5.   COLLATERAL CONSULTING SERVICES.

     (a)  While you are a member of the Board, you agree to advise the Company
on its strategic vision, assist the Company in its execution of strategic plans,
act as a Company spokesperson in the healthcare marketplace, assist the Company
in its interactions with governmental regulatory agencies in the healthcare and
securities sectors and participate in up to eight roundtable discussions with
executive officers of healthcare providers and and/or meetings with healthcare
providers each year.

100 Quannapowitt Parkway, Suite 405
Wakefield, MA 01880
Phone: 781 557 3000
Fax:   781 557 3140                  picis.com

<Page>

     (b)  In addition, you agree to attend and participate in at least six
private speaking engagements organized by the Company per year. It is
anticipated that each speaking engagement will include a dinner meeting with 10
to 16 executive officers of healthcare providers at which you shall give a
one-hour presentation, followed by a question and answer period with those in
attendance.

     (c)  You may also be asked to work on special projects for the Company.

     6.   COMPENSATION FOR COLLATERAL CONSULTING SERVICES. In consideration of
your participation in up to six speaking engagements per year and providing the
other collateral consulting services described in paragraph 4 above, the Company
will pay you an annual consulting fee of $59,999 per year, payable in arrears in
equal quarterly installments of $14,999.75 each on the last business day of each
calendar quarter. Upon termination of your tenure on the Board, your annual
speaking engagement and consulting fee will be prorated through the date of
termination.

     7.   EXPENSES FOR COLLATERAL SERVICES. The Company will pay or reimburse
you for all authorized and approved out-of-pocket expenses incurred in the
course of your performance of collateral services pursuant to this Agreement in
a manner consistent with the Company's policies with respect to reimbursement of
such expenses for its other consultants generally.

     8.   REGULATORY AND LEGAL COMPLIANCE. The Company does not anticipate that
you will perform any services for the Company which will require reporting,
registration, licensing or other compliance activities under any federal, state
or municipal laws and regulations relating to lobbying, contact with government
officials or similar matters. However, should any such regulatory compliance be
required, you shall be solely responsible for complying at your expense with
such regulatory requirements as may be applicable to you personally and the
Company shall be solely responsible for complying at its expense with such
regulatory requirements as may be applicable to the Company. You and the Company
shall each provide the other with such information as either may request in
order to prepare any reports or other documents required for any such regulatory
compliance.

     9.   REPRESENTATIONS. You warrant and represent to the Company that (a) you
are not prohibited by any law or regulation or by the terms of any contract or
agreement from performing services for the Company as contemplated by this
Agreement, and (b) as of the date hereof, you are not aware of any situation
that would pose a conflict of interest with respect to your performance of
services for the Company as contemplated hereby. You agree to promptly inform
the Company of any situations that may pose a conflict of interest which may
hereafter come to your attention.

     10.  CONFIDENTIALITY. During your tenure on the Board, you shall not
directly or indirectly use or disclose any Confidential Information (as defined
below) or Trade Secrets (as defined below) of the Company or the Company's
affiliates except in the interest and for the benefit of the Company. After the
end, for whatever reason, of your tenure on the Board, you shall not directly or
indirectly use or disclose any Trade Secrets of the Company or the Company's
affiliates. For a period of two (2) years after the end, for whatever reason, of
your tenure on the Board, you shall not directly or indirectly use or disclose
any Confidential Information. For purposes hereof, the term "Confidential
Information" means all non-Trade Secrets or proprietary information of the
Company or the Company's affiliates which has value to the Company or the
Company's affiliates and which is not known to the public or the Company's
competitors, generally. Confidential Information includes but is not limited to:
(i) inventions, product specifications, information about products under
development, research, development or business plans, production know-how and
processes, manufacturing techniques, equipment design and layout, test results,
financial information, customer lists, information about orders and transactions
with customers, sales and marketing strategies and plans, pricing strategies,
information relating to sources of materials and production costs, product
samples, technical information and know-how, personnel information and all
business records; (ii) information which is marked or otherwise designated as
confidential or proprietary by the Company; and (iii) information received by
the Company from others which the

Page 2 of 3
<Page>

Company has an obligation to treat as confidential. For purposes hereof, "Trade
Secrets" has the meaning set forth under applicable law.

     11.  RETURN OF RECORDS. Upon the end, for whatever reason, of your tenure
on the Board or upon request by the Company at any time, you shall immediately
return to the Company all documents, records and materials belonging and/or
relating to the Company, and any copies of such materials and destroy any such
documents, records or materials maintained on you own computer equipment.

     12.  INDEPENDENT CONTRACTOR. You are an independent contractor and not an
employee or agent of the Company. You shall be solely responsible for the
payment of any FICA or other payroll or employment taxes or contributions
applicable to your performance of services under this Agreement. You acknowledge
that you shall not participate in, or receive any benefits provided by, any of
the Company's retirement, health, welfare or other employee benefit plans or
programs.

     13.  ASSIGNABILITY. All services to be provided hereunder shall be
performed by you personally and you shall not assign, subcontract, delegate or
otherwise transfer this Agreement or the performance of services hereunder
without the prior written consent of the Company.

     14.  GOVERNING LAW. This Agreement shall be governed by and construed in
accordance with the laws of the state of Delaware without regard to the
principles of choice or conflicts of law thereof.

     15.  SEVERABILITY. The invalidity, illegality or enforceability of any
provision of this Agreement shall not affect the other provisions hereof, which
shall remain in full force and effect.

   If you are in agreement with the above, kindly so indicate by signing and
dating the enclosed copy of this letter in the space provided below and
returning it to R. Scott Lentz, Chief Financial Officer of the Company, at 100
Quannapowitt Parkway, Suite 405, Wakefield, Massachusetts 01880.

                                        Very truly yours,
                                        PICIS, INC.

                                        /s/ Todd C. Cozzens

                                        Todd C. Cozzens
                                        Chief Executive Officer

Acknowledged and agreed to this

20th day of June, 2006

/s/ Tommy G. Thompson
------------------------------------
Tommy G. Thompson

Page 3 of 3<Page>

                                                                   Exhibit 10.17

[PICIS LOGO]                                R. Scott Lentz
                                            Chief Financial Officer
                                            Tel: 781-557-3192
                                            Fax: 877-349-2053
                                            Email:scott_lentz@picis.com

July 1, 2006

Mr. Bernard Giroud
23 avenue Emile Deschanel
75007 Paris, France

via e-mail
                            Amended Engagement Letter
Dear Bernard:

This letter will confirm our understanding concerning your continuing service as
a member of the Board in light of your resignation as Chairman of the Board of
Directors (the "Board") of Picis, Inc. (the "Company") effective December 31,
2005 and the Company's adoption of a new Director Compensation Policy applicable
to all our independent directors, and will serve to amend and restate your most
recent engagement letter dated December 29, 2005.

     1.   TERM. Your tenure on the Board will continue until your resignation or
removal or until your successor is duly elected and qualified. We expect that
you will be a member of the Board for at least four years and that you will
notify the Company at least six months before resigning from the Board.

     2.   TITLE AND PRIMARY SERVICES. You have agreed to serve as Vice Chairman
of the Board effective January 1, 2006, as previously approved by the Board and
to continue to serve as a member of the Board's Compensation Committee. In
addition, you also agree to serve as a member of the Nominating and Governance
Committee if the Board elects you to fill a future vacancy on that committee.

     3.   COMPENSATION. In consideration of your services as a director of the
Company and your participation in each of the Board's regular quarterly meetings
and additionally called special meetings and conference calls, the Company will
pay you an annual Board fee of $50,000. You will receive an additional fee of
$2,000 for each meeting you attend in person and $1,000 for each meeting you
participate in by telephone. You will receive an additional annual fee of
$10,000 for each committee on which you serve (or $15,000 if you serve as
committee chairman), as well as $500 for each committee meeting you participate
in by telephone or in person. These revised fees will apply beginning today and
you will be paid at your previous fee rate up to this date, with annual fees
prorated as necessary. The annual fee for your last year of service will be
prorated through the date of termination. All the foregoing cash compensation
will be paid once a year following the annual meeting of shareholders.

     4.   EQUITY COMPENSATION. As additional consideration of your continuing
services as a member of the Board, and subject to Board approval, the Company
will grant you 150,000 stock options. These options will be issued at fair
market value on the date of grant, with 33% of the options vesting as of the end
of each calendar year commencing December 31, 2006 so that your options shall be
fully vested as of December 31, 2008, provided that you continue to serve on the
Board. The options will expire 10 years after grant, and will lapse 90 days
after the end, for whatever reason, of your tenure on the Board.

     5. EXPENSES. The Company will pay or reimburse you for all authorized and
approved out-of-pocket expenses incurred in the course of your performance of
services pursuant to this Agreement in a manner consistent with the Company's
policies with respect to reimbursement of such expenses for its Board members
generally.

100 Quannapowitt Parkway, Suite 405
Wakefield, MA 01880
Phone: 781-557-3000
Fax:   781-557-3140                      picis.com

<Page>

     6.   TERMINATION FEE. Upon a Change in Control (as defined in the Picis,
Inc. 2000 Stock Option Plan) or if you are at anytime removed from or not
re-elected to the Board of Directors of Picis, Inc., other than upon your own
initiative or at your own request, you shall be paid $75,000.

     7.   REGULATORY AND LEGAL COMPLIANCE. The Company does not anticipate that
you will perform any services for the Company which will require reporting,
registration, licensing or other compliance activities under any federal, state
or municipal laws and regulations relating to lobbying, contact with government
officials or similar matters. However, should any such regulatory compliance be
required, you shall be solely responsible for complying at your expense with
such regulatory requirements as may be applicable to you personally and the
Company shall be solely responsible for complying at its expense with such
regulatory requirements as may be applicable to the Company. You and the Company
shall each provide the other with such information as either may request in
order to prepare any reports or other documents required for any such regulatory
compliance.

     8.   REPRESENTATIONS. You warrant and represent to the Company that (a) you
are not prohibited by any law or regulation or by the terms of any contract or
agreement from performing services for the Company as contemplated by this
Agreement, and (b) as of the date hereof, you are not aware of any situation
that would pose a conflict of interest with respect to your performance of
services for the Company as contemplated hereby. You agree to promptly inform
the Company of any situations that may pose a conflict of interest which may
hereafter come to your attention.

     9.   CONFIDENTIALITY. During your tenure on the Board, you shall not
directly or indirectly use or disclose any Confidential Information (as defined
below) or Trade Secrets (as defined below) of the Company or the Company's
affiliates except in the interest and for the benefit of the Company. After the
end, for whatever reason, of your tenure on the Board, you shall not directly or
indirectly use or disclose any Trade Secrets of the Company or the Company's
affiliates. For a period of two (2) years after the end, for whatever reason, of
your tenure on the Board, you shall not directly or indirectly use or disclose
any Confidential Information. For purposes hereof, the term "Confidential
Information" means all non-Trade Secrets or proprietary information of the
Company or the Company's affiliates which has value to the Company or the
Company's affiliates and which is not known to the public or the Company's
competitors, generally. Confidential Information includes but is not limited to:
(i) inventions, product specifications, information about products under
development, research, development or business plans, production know-how and
processes, manufacturing techniques, equipment design and layout, test results,
financial information, customer lists, information about orders and transactions
with customers, sales and marketing strategies and plans, pricing strategies,
information relating to sources of materials and production costs, product
samples, technical information and know-how, personnel information and all
business records; (ii) information which is marked or otherwise designated as
confidential or proprietary by the Company; and (iii) information received by
the Company from others which the Company has an obligation to treat as
confidential. For purposes hereof, "Trade Secrets" has the meaning set forth
under applicable law.

     10.  RETURN OF RECORDS. Upon the end, for whatever reason, of your tenure
on the Board or upon request by the Company at any time, you shall immediately
return to the Company all documents, records and materials belonging and/or
relating to the Company, and any copies of such materials and destroy any such
documents, records or materials maintained on you own computer equipment.

     11.  INDEPENDENT CONTRACTOR. You are an independent contractor and not an
employee or agent of the Company. You shall be solely responsible for the
payment of any taxes or contributions applicable to your performance of services
under this Agreement. You acknowledge that you shall not participate in, or
receive any benefits provided by, any of the Company's retirement, health,
welfare or other employee benefit plans or programs.

     12.  ASSIGNABILITY. All services to be provided hereunder shall be
performed by you personally and you shall not assign, subcontract, delegate or
otherwise transfer this Agreement or the performance of services hereunder
without the prior written consent of the Company.

Page 2 of 3
<Page>

     13.  GOVERNING LAW. This Agreement shall be governed by and construed in
accordance with the laws of the state of Delaware without regard to the
principles of choice or conflicts of law thereof.

     14.  SEVERABILITY. The invalidity, illegality or enforceability of any
provision of this Agreement shall not affect the other provisions hereof, which
shall remain in full force and effect.

   If you are in agreement with the above, kindly so indicate by signing and
dating the enclosed copy of this letter in the space provided below and
returning it my attention at 100 Quannapowitt Parkway, Suite 405, Wakefield,
Massachusetts 01880.

                                            Very truly yours,
                                            PICIS, INC.

                                            /s/ R, Scott Lentz

                                            R, Scott Lentz
                                            Corporate Secretary

Acknowledged and agreed to this

1st day of July, 2006.

/s/ Bernard Giroud
-------------------------------------
Bernard Giroud

Page 3 of 3

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00109-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00109-of-00352.parquet"}]]