Document:

Separation Agreement between Registrant and Lynne Zydowsky

 Exhibit 10.12 
  
 SEPARATION AGREEMENT 
  
 This Separation Agreement (the “Agreement”) is made by and between Renovis, Inc. (hereinafter, the “Company”) and Dr. Lynne
Zydowsky (“Zydowsky”) (together referred to as “the Parties”) and is entered into as of February 3, 2003, effective the eighth day after Zydowsky’s signature without revocation (the “Effective Date”).

  
 WHEREAS, Zydowsky is employed by the Company; 
  
 WHEREAS, Zydowsky has entered into with the Company both an Employment Agreement dated
February 1, 2000 (the “Employment Agreement”) and an Indemnity Agreement effective July 1, 2000 (the “Indemnity Agreement”); 
  

WHEREAS, Zydowsky purchased 250,000 shares of the Company’s Common Stock (the “Founders Stock”) pursuant to a Founder’s Stock Purchase
Agreement dated March 13, 2000, between the Company and Zydowsky (the “Founders’ Stock Purchase Agreement”), which agreement provides that the Company has the option to repurchase shares (if any) as to which the Company’s
repurchase option has not lapsed only upon Zydowsky’s employment termination from the Company (the “Repurchase Option”); 
  
 WHEREAS, the Company on April 21, 2000, September 14, 2001, and May 9, 2002, granted Zydowsky incentive stock options to purchase an aggregate of 350,000 shares of
the Company’s common stock (the “Stock Options”) subject to the terms and conditions of the Company’s 2000 Equity Incentive Plan and related amendment thereto, including any exhibits thereto (collectively, the
“Plan”); 
  
 NOW THEREFORE, in consideration of the mutual
promises made herein, the Parties hereby agree as follows: 
  
 1.
Employment/ Consulting. Zydowsky’s employment as the Company’s Senior Vice-President of Corporate Development will continue (with all of Zydowsky’s current compensation and benefits of any kind associated therewith undiminished
in any way without interruption, except for the board observation rights set forth in Section 1 of the Employment Agreement which will terminate on January 31, 2003) through and including March 31, 2003 except that starting February 3, 2003,
Zydowsky will no longer be required either to execute any binding agreements on the Company’s behalf or to perform any Company statutory officer and/or or Company financial related functions. The Company agrees that the termination of
Zydowsky’s employment with the Company will take place at day’s end on March 31, 2003 (the “Termination Date”) and constitutes a “Constructive Termination” (as defined in the Employment Agreement). The Company
acknowledges that Zydowsky is entitled to a 2002 annual bonus pursuant to the Employment Agreement, which the Company shall satisfy in full by a special payment to Zydowsky in lieu of a 2002 Bonus in an amount equal to ten percent (10%) of
Zydowsky’s base salary in effect as of the Effective Date (payment agreed to total $23,750, less applicable taxes or other required withholdings) (the “Special Payment”). The Special Payment shall be paid to Zydowsky on or prior to
the Termination Date. Through the Termination Date, Zydowsky shall continue to be a full-time 

  

 1 

 
employee of the Company, although the Parties anticipate that Zydowsky’s responsibilities will gradually be reduced by the Company in a reasonable business-like
manner, such that it is unlikely that Zydowsky will be required to commit more than one-half of her professional time and Company regular business hours to the Company during the month of March 2003. From the Termination Date through September 30,
2003 (the “Separation Date”, collectively the “Consulting Period”), Zydowsky will be available to assist the Company’s Senior Executives during regular business hours at mutually agreeable times following reasonable advanced
written request (including email) for up to a total of 25 days; provided that Zydowsky will not be expected to provide more than a maximum of eight hours of services in any individual day. Upon the Company’s request and by mutual agreement,
Zydowsky may (but is not obligated) to provide consulting services beyond the 25 days at a rate of $250/ hour. 
  
 2. Severance/ Settlement Compensation. 
  
 (a) Contractual Severance. During the Consulting Period, the Company will pay (at the Company’s regular pay periods and whether or not Zydowsky’s
consulting services described in Section 1 above are either fully, partially or not used; provided, however, that if requested to provide consulting services pursuant to this Agreement, Zydowsky shall have provided such consulting services in
accordance with the terms of this Agreement) the equivalent of Zydowsky’s current gross base salary (payments agreed to total $118,750) subject to any taxes or other authorized withholdings only. Such total payment shall be timely and
accurately reported to Zydowsky and the government on a Form W-2. 
  
 (b)
Benefits. After the Termination Date, Zydowsky will pay for any full health-related insurance benefits coverage under COBRA as desired and as available. Zydowsky acknowledges and agrees that, except as expressly provided for by this
Agreement, she will not be entitled to Company benefits of any kind following the Termination Date. 
  
 (c) Acceleration of Lapsing of Repurchase Option; Other Equity-Related Matters. The Parties agree that Zydowsky will have already vested as of the
Termination Date in both: 1) 192,708 shares of the Founders Stock (i.e., the Company’s Repurchase Option has already lapsed with respect to that number of shares); and 2) 240,624 shares of common stock under the Stock Options (i.e., the Stock
Options will have vested and become exercisable with respect to an aggregate of 240,624 shares of common stock). The Parties further agree that as part of the Settlement Compensation, Zydowsky will further vest (i.e., as applicable, the
Company’s Repurchase Option will completely lapse with respect to): (1) in all remaining unvested shares of the Founders Stock and; 2) in a further six months (following the Termination Date) of all remaining unvested Stock Options, in the case
of both (1) and (2) such additional vesting shall occur on the Termination Date. After taking into account the foregoing acceleration of vesting, as of the Termination Date, Zydowsky shall have vested (i.e., the Company’s Repurchase Option
shall have lapsed) with respect to 250,000 shares of the Founders Stock and the Stock Options shall have vested and become exercisable with respect to 284,374 shares of common stock. All of the Founders Stock and Stock Options shall otherwise
continue to be subject to all the other terms of the 

  

 2 

 
Founders’ Stock Purchase Agreement and the Plan, respectively. The Company represents and warrants that, to its knowledge, as of the Termination Date Zydowsky
will be the full and rightful owner of the Founders Stock and Stock Options described in this Section 2(c) and such Founders Stock and Stock Options, together with any additional options, shares and/or other rights derived therefrom, remain and have
remained subject to the Founders’ Stock Purchase Agreement, the Plan the Company’s Bylaws and the Company’s then in effect Certificate of Incorporation (the “Certificate”), the Company’s Amended and Restated Voting
Agreement, the Company’s Amended and Restated Right of First Refusal and Co-Sale Agreement and the Company’s Amended and Restated Investor Rights Agreement, each as applicable. Within 10 days after the Termination Date, the Company shall
deliver to Zydowsky a certificate representing all of the Founders Stock, which certificate shall such be subject to only such legends as are consistent with the agreements to which Zydowsky is a party, the Company’s Bylaws, the Certificate and
the Securities Act of 1933, as amended. Promptly after any exercise by Zydowsky of any Stock Options in accordance with the terms of such Stock Options, one or more certificates representing the shares with respect to which such Stock Options were
exercised shall be delivered to Zydowsky and shall be subject to only such legends as are consistent with the agreements to which Zydowsky is a party, the Company’s Bylaws, the Certificate and the Securities Act of 1933, as amended. The Company
acknowledges and agrees that, subject to Zydowsky’s compliance with the terms of Section 1 of this Agreement, Zydowsky will have provided the Company with “Continuous Service” without interruption through the Separation Date as
defined and described in the Plan, and thus the Stock Options will be fully exercisable for 90 days following the Separation Date. 
  
 (d) Laptop Computer; Other Items; Access; Company Publications. Within 10 business days of the Separation Date, the Company shall download and delete all
Company files and Company proprietary software on the laptop computer Zydowsky has used with the Company, and return the Computer otherwise in the same condition to Zydowsky for her personal use and free and clear ownership along with the related
items (e.g., monitor, mouse, power chord) previously provided for Zydowsky’s use (including for the Consulting Period). Zydowsky will also be given for her personal use free and clear ownership of her Company cell phone. Through the end of the
Consulting Period, Zydowsky will maintain both a Company voicemail box and email address. The Company will continue to list Zydowsky as a company founder on all Company website(s) and outside presentations which mention the Company’s founders
through the Separation Date; thereafter, in response to any inquiries, the Company shall confirm that Zydowsky was one of its original Board members and its first president and chief operating officer who positively contributed to the startup the
Company. 
  
 3. Expenses. The Company shall reimburse only those
reasonable business expenses incurred in accordance with the Company’s written policies for expense reimbursements and with prior written authorization by either the Company’s CEO or CFO. Zydowsky agrees and acknowledges that, from and
after the Effective Date, except as expressly provided for in this Agreement, Zydowsky will not be entitled to any payments, reimbursements or benefits of any kind, from the Company. Zydowsky further agrees and acknowledges that she will return all
Company credit cards as of the Effective Date. 
  

 3 

 4. Releases of Claims. 
  
 (a) Zydowsky agrees that the Company’s obligations in this Agreement (compliance with its obligations in Sections 1, 2(a),
2(c)each constituting independent conditions precedent to Zydowsky’s release) represents settlement in full of all outstanding obligations owed to Zydowsky by (and any and all actual and/or potential claims by Zydowsky against) the Company and
its predecessors, successors, divisions, subsidiaries, officers, managers, supervisors, agents and employees. Zydowsky hereby fully and forever releases the Company and its officers, directors, employees, agents, investors, shareholders,
administrators, affiliates, divisions, subsidiaries, predecessor and successor corporations, and assigns (“collectively, the Company Releasees”), from, and agrees not to sue concerning, or in any manner to institute, prosecute or pursue
(except to enforce the Agreement and related surviving rights), any claim, complaint, charge, duty, obligation or cause of action relating to any matters of any kind, whether presently known or unknown, suspected or unsuspected, that Zydowsky may
possess against any of the Company Releasees arising from any omissions, acts or facts that have occurred up until and including the Effective Date of this Agreement. 
  
 (b) The Company agrees that Zydowsky’s obligations in this Agreement (compliance with her material obligations each constituting
independent conditions precedent to the Company’s release) represent settlement in full of all outstanding obligations owed to the Company Releasees by (and any and all actual and/or potential claims by the Company against) Zydowsky and her
respective heirs, family members, executors, attorneys, agents and assigns. The Company, on its own behalf, and (to the fullest extent allowed) on behalf of its divisions, subsidiaries, predecessor and successor corporations, hereby fully and
forever releases Zydowsky and her respective heirs, family members, and executors, agents, attorneys and assigns (collectively, the “Zydowsky Releasees”), from, and agrees not to sue concerning, or in any manner to institute, prosecute or
pursue, any claim, complaint, charge, duty, obligation or cause of action relating to any matters of any kind, that the Company and/or the Company Releasees may possess against Zydowsky and/or any of the Zydowsky Releasees, arising from any
omissions, acts or facts that have occurred up until and including the Effective Date of this Agreement. and that are known, or in the exercise of reasonable diligence should be known to, the Company’s Board of Directors. 
  
 (c) The above releases include, without limitation: 
  
 (i) any and all claims relating to or arising out of Zydowsky’s employment
relationship with the Company and the termination of that relationship (except for any claims for indemnity arising under the Indemnity Agreement and/or the indemnification provisions of the Company’s Certificate of Incorporation and Bylaws);

  
 (ii) any and all claims relating to, or arising from, Zydowsky’s
right to purchase, or actual purchase of shares of stock of the Company, including, without limitation, any claims for fraud, misrepresentation, breach of fiduciary duty, breach of duty under applicable state corporate law, and securities fraud
under any state or federal law; 
  

 4 

 (iii) any and all claims for wrongful discharge of employment; termination in violation of public policy;
discrimination; harassment; retaliation; breach of contract, both express and implied; breach of a covenant of good faith and fair dealing, both express and implied; promissory estoppel; negligent or intentional infliction of emotional distress;
negligent or intentional misrepresentation; negligent or intentional interference with contract or prospective economic advantage; unfair business practices; defamation; libel; slander; negligence; personal injury; assault; battery; invasion of
privacy; false imprisonment; conversion; 
  
 (iv) any and all claims for
violation of any federal, state or municipal statute, including, but not limited to, Title VII of the Civil Rights Act of 1964; the Civil Rights Act of 1991; the Americans with Disabilities Act of 1990; the Fair Labor Standards Act; the Employee
Retirement Income Security Act of 1974; the Worker Adjustment and Retraining Notification Act; the Family and Medical Leave Act; the California Family Rights Act; the California Fair Employment and Housing Act; and the California Labor Code;

  
 (v) any and all claims for violation of the federal, or any state,
constitution; 
  
 (vi) any and all claims arising out of any other laws
and regulations relating to employment or employment discrimination; 
  
 (vii) any claim for any loss, cost, damage, or expense arising out of any dispute over either the non-withholding or other tax treatment only of any of the proceeds paid to Zydowsky as a result of this Agreement; and 
  
 (viii) any and all claims for attorneys’ fees and costs, not paid herein.

  
 (d) The Parties agree that the releases set forth in this Paragraph 4
shall be and remain in effect in all respects as complete general releases as to the matters released. These releases expressly do not extend to any obligations incurred under (or excepted in) this Agreement. 
  
 (e) In accordance with the Older Workers Benefit Protection Act of 1990, Zydowsky
confirms that she has been advised of and is aware of the following: 
  
 (i) She has the right to consult with an attorney before signing this Agreement; 
  
 (ii) She has twenty-one (21) days from the date she receives a copy of this Agreement to consider it; 
  
 (iii) She may waive the above described twenty-one (21) day notice period by signing this Agreement prior to expiration of the notice period; and 
  

 5 

 (iv) She has seven (7) days after signing this Agreement to revoke her acceptance of it, and this Agreement will
not be effective until that revocation period has expired. 
  
 5. Civil
Code Section 1542 Waivers; Release Exceptions. Zydowsky represents that she is not aware of any claim by her or by the Zydowsky Releasees against any of the Company Releasees other than the claims that are released by this Agreement. The Company
represents that it is not aware of any claim by it, the Company Releasees or any other third party against Zydowsky other than the claims that are released by this Agreement. Each Party acknowledges that she/it has been advised by legal counsel and
is familiar with the provisions of California Civil Code Section 1542, which provides as follows: 
  
 A GENERAL RELEASE DOES NOT EXTEND TO CLAIMS WHICH THE CREDITOR DOES NOT KNOW OR SUSPECT TO EXIST IN HIS FAVOR AT THE TIME OF EXECUTING THE RELEASE, WHICH IF KNOWN
BY HIM MUST HAVE MATERIALLY AFFECTED HIS SETTLEMENT WITH THE DEBTOR. 
  
 Each Party, being
aware of said code section, agrees to expressly waive any rights she/it may have there under, as well as under any other statute or common law principles of similar effect. Nevertheless, none of the waivers and releases in this Agreement shall
waive, release, apply to and/or limit in any way either: (1) Zydowsky’s legally-vested rights (if any) earned through the Separation Date under any benefit plan of the Company (e.g., Company medical plan, the Plan, Founders Stock Purchase
Agreement, 401(k) plan), pursuant to any Company insurance policy(ies), and/or that are not waivable under applicable law (e.g., regarding unemployment, disability benefits rights, workers compensation, ERISA); (2) Employee’s right to
indemnification, duty to defend and to be held harmless by the Company pursuant to any contract (e.g., the Indemnification Agreement), applicable insurance policy(ies), statute(s), common law obligation(s), or otherwise; (3) claims that the Company
has against Zydowsky based upon facts not known to the Board of Directors of the Company as of the Effective Date; (4) either Party’s rights to enforce the Agreement; and (5) either Party’s rights to raise claims for the other Party’s
(and associated releasees’) post-Effective Date activities. 
  
 6.
Confidentiality. Except as permitted herein, the Parties agree to maintain in complete confidence the terms of this Agreement (hereinafter collectively referred to as “Separation Information”). Except as required by law or
otherwise permitted herein, Zydowsky may disclose Separation Information only to her immediate family members, in any process to enforce (or defend against claimed breaches of) the Agreement, Zydowsky’s legal counsel, accountant, financial
planner and any professional tax advisor, and must prevent disclosure of any Separation Information to all other third parties. The Company agrees to disclose Separation Information only to the Board of Directors and those Company executives
determined by the Company to need such Separation Information, designated deposition officers in response to valid subpoenas issued to the Company, the Court and/or arbitrator in proceedings to enforce the terms of this Agreement, the Company’s
attorneys, accountants and any professional tax advisor to the extent that they need to know the Separation Information in order to provide advice on tax treatment or to provide tax returns, in 

  

 6 

 
public filings by the Company with the Securities and Exchange Commission to the extent necessary, or as otherwise required by business necessity, and to the extent
necessary to prevent disclosure of any Separation Information to all other third parties. The Parties agree that they will not otherwise publicize, directly or indirectly, any Separation Information, other than to disclose words to the effect that
“any issues have been settled to the mutual satisfaction of all Parties,” “I can’t discuss that because of an agreement.” Notwithstanding anything to the contrary herein, the Company and Zydowsky mutually agree that
additional language may be used in connection with the Parties’ announcements of the change in Zydowsky’s relationship with the Company. Such communications shall consist of words to the substantive effect that: “Zydowsky particularly
enjoys working with new start-ups, helping them transform into successful companies. Her mission in this regard has now been completed with Renovis. Zydowsky is exploring such new opportunities and is transitioning her employment with Renovis over
the next two months, but will serve as a Company consultant to its senior management team thereafter. These past three years have been successful as Renovis moves from an emerging company to one that is becoming fully integrated.” 

 
 7. Intellectual Property/ Confidentiality Agreements. Zydowsky agrees to
observe and abide by the enforceable surviving terms of the Confidentiality and Proprietary Information Agreement between Zydowsky and the Company, as well as Section 15 of the Employment Agreement. 
  
 8. No Cooperation. Zydowsky agrees that she will not act in any manner that is
intended to (and does) materially illegally damage the business of the Company. The Parties acknowledge that Zydowsky’s employment with any of the Company’s competitors shall not, in and of itself, constitute a breach of this provision.
The Company agrees that it will not act in any manner that is intended to (and does) materially illegally damage Zydowsky. Each Party further agrees that she/it will not knowingly counsel or assist any attorneys or their clients in the presentation
or prosecution of any disputes, differences, grievances, claims, charges, or complaints by any third party against the other Party, unless involuntarily under a subpoena or other court order to do so. Each Party agrees both to immediately notify the
other Party upon receipt of any such subpoena or court order related in any way to Zydowsky’s Company employment, and to furnish, within three (3) business days of its receipt, a copy of such subpoena or court order to the other Party. If
approached by anyone for counsel or assistance in the presentation or prosecution of any disputes, differences, grievances, claims, charges, or complaints by those third parties against the other Party, the contacted Party shall state no more than
that she/it cannot provide counsel or voluntary assistance. 
  
 9.
Non-Disparagement. Zydowsky agrees to refrain from any defamation, libel or slander of the Company (including its board of directors, executives, employees, advisors and investors), and any tortuous interference with the contracts,
relationships and prospective economic advantage of the Company. The Company (meaning its board of directors and executive officers) agrees to refrain from any defamation, libel or slander of Zydowsky, and any tortuous interference with the
contracts, relationships and prospective economic advantage of Zydowsky. Upon inquiry by potential future employers, the Company will direct such inquiries to the Company employee in charge of the human resources function who shall only confirm the
following (and cite it as pursuant 

  

 7 

 
to Company policy with respect to all former employees): Zydowsky’s positions held, dates of employment and consulting, final employment compensation levels and
only any other information and/or documentation legally required to be disclosed. 
  
 10. No Admission of Liability. Each Party understands and acknowledges that this Agreement constitutes a compromise and settlement of any and all potential disputed claims. No action taken by either Party, either previously or in
connection with this Agreement, shall be deemed or construed to be: (a) an admission of the truth or falsity of any potential claims; or (b) an acknowledgment or admission by either Party of any fault or liability whatsoever to the other Party or to
any third party. 
  
 11. Costs. The Parties shall each bear their own
costs, attorneys’ fees and other fees incurred in connection with the preparation of this Agreement. 
  
 12. Authority. The Company represents and warrants that the undersigned have the authority to act on behalf of the Company and to bind the Company and all
who may claim through it to the terms and conditions of this Agreement. Zydowsky represents and warrants that she has the capacity to act on her own behalf and on behalf of all who might claim through him to bind them to the terms and conditions of
this Agreement. Each Party warrants and represents that there are no liens or claims of lien or assignments in law or equity or otherwise of or against any of the claims or causes of action released herein. 
  
 13. No Representations. Each Party represents that she/it has consulted with or
has had the opportunity to consult with an attorney, and has carefully read and understands the scope and effect of the provisions of this Agreement. Each Party has not relied upon any representations or statements made by the other Party or that
Party’s agents which are not specifically set forth in this Agreement. 
  
 14. Severability. In the event that any provision or any portion of any provision hereof becomes or is declared by a court of competent jurisdiction to be illegal, unenforceable or void, this Agreement shall continue in full force
and effect without said provision or portion of provision. 
  
 15.
Attorneys’ Fees. In the event that either Party brings an action to enforce or effect its rights under this Agreement, the prevailing party shall be entitled to recover its costs and expenses, including the costs of mediation,
arbitration, litigation, court fees, etc., plus reasonable attorneys’ fees, incurred in connection with any such an action. 
  
 16. Entire Agreement. This Agreement and the surviving terms of the other agreements referenced in it (as modified by this Agreement) represent the entire
agreement and understanding between the Company and Zydowsky concerning Zydowsky’s separation from the Company and the events leading thereto and associated therewith, and otherwise supersedes and replaces any and all prior agreements and
understandings concerning Zydowsky’s relationship with the Company. 
  

 8 

 17. No Oral Modification. This Agreement may only be amended in writing signed by Zydowsky and a duly
authorized officer of the Company. 
  
 18. Governing Law. This
Agreement shall be governed by the laws of the State of California, without regard for choice of law provisions. 
  
 19. Dispute Resolution / Attorneys’ Fees. Unless otherwise prohibited by law or specified below, all disputes, claims, and causes of action (including
but not limited to any claims of statutory discrimination of any type), in law or equity, arising from or relating to this Agreement or its enforcement, performance, breach, or interpretation, or to your employment with the Company or the
termination of that employment, shall be resolved solely and exclusively by final, binding and confidential arbitration through Judicial Arbitration & Mediation Services/Endispute, Inc. (“JAMS”) under the then existing JAMS arbitration
rules. Zydowsky understands and agrees that this provision waives her right to a jury trial on these claims. This arbitration shall be held in the San Francisco Bay Area. Nothing in this section is intended to prevent either Party from obtaining
injunctive relief in court to prevent irreparable harm pending the conclusion of any such arbitration. 
  
 20. Counterparts Facsimile. This Agreement may be executed in counterparts and by facsimile, and each counterpart and facsimile shall have the same force and
effect as an original and shall constitute an effective, binding agreement on the part of each of the undersigned, upon receipt of the original or faxed copy of the counterpart signed by the other Party’s legal counsel. 
  
 21. Voluntary Execution of Agreement. This Agreement is executed voluntarily and
without any duress or undue influence on the part or behalf of the Parties hereto, with the full intent of releasing all claims. The Parties acknowledge that: 
  

(a) They have read this Agreement; 
  
 (b) They have been represented in the preparation, negotiation, and execution of this Agreement by legal counsel of their own choice; 
  
 (c) They understand the terms and consequences of this Agreement and of the releases
it contains; 
  
 (d) They are fully aware of the legal and binding effect
of this Agreement. 
  

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 IN WITNESS WHEREOF, the Parties have executed this Agreement on the respective dates set forth below. 

 

	 	 	 	 	RENOVIS, INC.
			
	 Dated:    2/3/2003

	 	 By:
	 	 /s/    DR. EDWARD
PENHOET        

	 	 	 	 	 Dr. Edward Penhoet,
 Chairman of the
Board

			
	 	 	 	 	RENOVIS, INC.
			
	 Dated:    2/3/2003

	 	 By:
	 	 /s/    DR. COREY
GOODMAN        

	 	 	 	 	 Dr. Corey Goodman,        
 President and CEO

			
	 Dated:    2/3/2003

	 	 By:
	 	 /s/    DR. LYNNE ZYDOWSKY
        

	 	 	 	 	Dr. Lynne Zydowsky         

  

 10Net Lease dated September 27, 2000

 Exhibit 10.28 
  
 NET LEASE 
 BASIC LEASE INFORMATION 
  

	 DATE:
	 	September 27, 2000
		
	 LANDLORD:
	 	Utah Partners, Ltd., a California limited partnership
		
	 TENANT:
	 	Renovis, Inc., a Delaware corporation
		
	 PREMISES:
	 	All rentable area in the Building located at 270 Littlefield Avenue, South San Francisco, California, as shown on Exhibit A attached hereto. Landlord and Tenant stipulate that for
all purposes of this Lease the Premises contains 15,500 rentable square feet.
		
	 PROPERTY:
	 	Edgewater Business Park
		
	 USE:
	 	General office and administrative purpose, research and development, laboratory, bio-services, and marketing.
		
	 TERM:
	 	Approximately Five (5) years

  

		
	 ESTIMATED COMMENCEMENT DATE:
	 	October 1, 2000
		
	 INITIAL BASE RENT:
	 	$56,110.00, subject to adjustment pursuant to Section 4.b.
		
	 TENANT’S PERCENTAGE SHARE:
	 	100%
		
	 SECURITY DEPOSIT:
	 	$673,320.00 Letter of credit.
		
	 BROKERS:
	 	None.
		
	 ADDRESS FOR NOTICES: Landlord:
	 	 Utah Partners, Ltd.
 c/o Simeon Commercial
Properties
 655 Montgomery Street; Suite 1190
 San Francisco, CA 94111
 Attn: Director of Property Management

		
	            Tenant:
	 	 To Tenant at the Premises
 Attn: Ms. Lynne
Zydowsky

		
	 	 	 
		
	 LANDLORD’S INITIALS: /s/ M.E.
	 	TENANT’S INITIAL’S: /s/ L.Z.

 TABLE OF CONTENTS 
  

	 	 	 	  	Page

	 1.
	 	 Premises.
	  	1
	 2.
	 	 Term.
	  	1
	 3.
	 	 Rent
	  	2
	 4.
	 	 Base Rent
	  	2
	 5.
	 	 Operating Expenses
	  	2
	 6.
	 	 Proration of Rent
	  	5
	 7.
	 	 Premises As-Is
	  	5
	 8.
	 	 Use of the Premises
	  	5
	 9.
	 	 Alterations
	  	7
	 10.
	 	 Repairs
	  	9
	 11.
	 	 Damage or Destruction
	  	9
	 12.
	 	 Eminent Domain
	  	10
	 13.
	 	 Indemnity and Insurance
	  	10
	 14.
	 	 Assignment or Sublet
	  	12
	 15.
	 	 Default
	  	15
	 16.
	 	 Landlord’s Right to Perform Tenant’s Covenants
	  	17
	 17.
	 	 Letter of Credit
	  	17
	 18.
	 	 Surrender of Premises
	  	19
	 19.
	 	 Holding Over
	  	19
	 20.
	 	 Access to Premises
	  	19
	 21.
	 	 Signs
	  	19
	 22.
	 	 Subordination
	  	20
	 23.
	 	 Transfer of the Property
	  	20
	 24.
	 	 Estoppel Certificates; Financial Statements
	  	20
	 25.
	 	 Mortgagee Protection
	  	21
	 26.
	 	 Attorneys’ Fees
	  	21
	 27.
	 	 Brokers
	  	21
	 28.
	 	 Parking
	  	22
	 29.
	 	 Utilities and Services
	  	22
	 30.
	 	 Investment Rights
	  	22
	 31.
	 	 Acceptance
	  	23
	 32.
	 	 Use of Building Name
	  	23
	 33.
	 	 Recording
	  	23
	 34.
	 	 Quitclaim
	  	23
	 35.
	 	 Notices
	  	23
	 36.
	 	 Landlord’s Exculpation
	  	24
	 37.
	 	 Additional Structures
	  	24
	 38.
	 	 Consents and Approvals
	  	24
	 39.
	 	 General
	  	24

  

	 EXHIBIT “A”: Premises Designation

	 EXHIBIT “A-1”: Property Site Plan

	 EXHIBIT “B”: Commencement Date Memorandum

	 EXHIBIT “C”: Rules and Regulations

 NET LEASE 
  
 THIS LEASE, which is effective as of the date set forth in the Basic Lease Information, is entered by Landlord and Tenant, as set forth in the Basic Lease
Information. Terms which are capitalized in this Lease shall have the meanings set forth in the Basic Lease Information. 
  
 1. Premises. 
  
 Landlord leases to Tenant, and Tenant leases from Landlord, the Premises described in the Basic Lease Information (as shown on Exhibit A), together with the
right in common to use the Common Areas. The Common Areas shall mean the areas and facilities within the land shown on Exhibit A-1 (the “Land”) and within the Building identified in the Basic Lease Information (the “Building”)
and within all other buildings and improvements now or hereafter located on the Land, provided and designated by Landlord for the general use, convenience or benefit of Tenant and other tenants and occupants of the Property (e.g., restrooms;
janitorial, telephone and electrical closets; sidewalks; driveways, public lobbies, entrances and stairs; and unreserved parking areas). Landlord reserves the right to make changes to the Common Areas, provided that such changes do not permanently
materially adversely affect Tenant’s reasonable access to the Premises or reduce the parking spaces available to Tenant to less than that required by applicable Legal Requirements (as defined in Section 8.c. below). The Building and such other
buildings and improvements now or hereafter located on the Land are collectively referred to in this Lease as the “Buildings”. The Land, the Buildings and the Common Areas are collectively referred to in this Lease as the
“Property” or the “Real Property”. 
  
 2. Term.

  
 a. Lease Term. The term of this Lease (the “Term”)
shall commence on the Commencement Date (as defined in Subsection 2.b.) and, unless terminated on an earlier date in accordance with the terms of this Lease, shall end on the date (the “Expiration Date”) that is the last day of the
calendar month in which occurs the fifth (5th) annual anniversary of the Commencement Date, 
  
 b. Commencement Date. The “Commencement Date” of this Lease shall be the date on which Landlord delivers the Premises to Tenant in their then “as-is” condition. 
  
 c. Premises Not Delivered. If, for any reason, either Commencement Date does not
occur by the Estimated Commencement Date, the failure shall not affect the validity of this Lease, or the obligations of Tenant under this Lease, and Landlord shall not be subject to any liability. Notwithstanding the foregoing, in the event that
the Commencement Date does not occur by October 31, 2000, as such date shall be extended for delays caused by Force Majeure (such date, as so extended, the “Trigger Date”), then Tenant shall have the right to terminate this Lease by notice
to Landlord given, if at all, within ten (10) days after the Trigger Date. For purposes of this Lease, “Force Majeure” shall mean strikes, lock-outs, labor disputes, shortages of material or labor, fire, earthquake, flood or other
casualty, acts of God or any other cause (other than financial inability) beyond the reasonable control of Landlord. If Tenant exercises such termination option, this Lease shall terminate effective as of the tenth (10th) day following delivery of
Tenant’s notice of termination, unless the Commencement Date shall occur prior to such effective termination date. If this Lease is so terminated, Landlord shall return any advance payment of Rent, the Letter of Credit and any Letter of Credit
Proceeds (as such terms are defined in Section 17), and the parties thereupon shall be released of further liability under this Lease. 
  
 d. Commencement Date Memorandum. When the Commencement Date is determined, upon either party’s request the parties shall execute a Commencement Date
Memorandum, in the form attached hereto as Exhibit B, setting forth the Commencement Date and the Expiration Date. 
  

 1 

 3. Rent. 
  
 As used in this Lease, the term “Rent” shall include: (i) the Base Rent; (ii) Operating Expenses payable by Tenant pursuant to Section 5 below; and (iii)
all other amounts which Tenant is obligated to pay under the terms of this Lease, including, without limitation, the parking charges payable by Tenant pursuant to Section 28 below. All amounts of money payable by Tenant to Landlord shall be paid
without prior notice or demand, deduction or offset. If any installment of Base Rent is not paid by Tenant by the fifth (5th) day of the month, or if any payment of Operating Expenses or any other amount payable by Tenant is not paid within five (5)
days of the due date thereof, Tenant shall pay to Landlord a late payment charge equal to five percent (5%) of the amount of the delinquent amount, in addition to the amount of Rent then owing, regardless of whether a notice of default or notice of
termination has been given by Landlord. In addition to the five percent (5%) late charge, any Base Rent, Operating Expenses or other amounts owing hereunder which are not paid within five (5) days after the date they are due shall thereafter bear
interest at the rate (“Interest Rate”) which is the lesser of eighteen percent (18%) per annum or the maximum rate permitted by applicable law. Notwithstanding the foregoing, Landlord shall give Tenant notice of non-payment and five (5)
days from receipt of such notice to cure such non-payment once in each calendar year before assessing such late fees and/or interest in such calendar year. 
  
 4. Base Rent. 
  
 a. Initial Base Rent. Commencing on the Commencement Date, and thereafter on the first day of each calendar month of the Term, Tenant shall pay monthly base
rent (“Base Rent”) for the Premises to Landlord (or other entity designated by Landlord), in advance, at Landlord’s address for notices (as set forth in the Basic Lease Information) or at such other address as Landlord may designate
in writing. The initial Base Rent shall be the amount set forth in the Basic Lease Information. Base Rent payable hereunder for the first full calendar month after Tenant’s obligation to pay Base Rent commences shall be paid upon Tenant’s
execution of this Lease. 
  
 b. Base Rent Adjustment. Effective as of
each annual anniversary of the Commencement Date, the Base Rent payable by Tenant for the Premises shall increase to one hundred three percent (103%) of the Base Rent then in effect for the Premises (without taking into account any temporary rental
abatements then in effect). 
  
 5. Operating Expenses. 
  
 a. Operating Expenses. Tenant shall pay Tenant’s Percentage Share of
Operating Expenses incurred by Landlord during each calendar year falling in whole or in part during the Term. 
  
 b. Operating Expenses. The term “Operating Expenses” shall include all reasonable expenses and costs of every kind and nature, except as provided
in the next paragraph, which Landlord shall pay or become obligated to pay because of or in connection with the ownership, management, administration, maintenance, repair and operation of the Premises, the Buildings, the Common Areas and the balance
of the Property, to the extent allocable, as reasonably determined by Landlord, to the Building in which the Premises is located. Operating Expenses shall include, without limitation, the following: (i) all impositions relating to the Real Property,
including Real Property Taxes (as defined in Section 5.d.); (ii) premiums for insurance relating to the Real Property, including as set forth in Sections 13.b., 13.d. and 13.i., and insurance deductibles paid by Landlord; (iii) wages, salaries,
bonuses and expenses and benefits (including hospitalization, medical, surgical, retirement plan, pension plan, union dues, life insurance, including group life insurance, welfare and other fringe benefits, and vacation, holidays and other paid
absence benefits, and 

  

 2 

 
costs of uniforms) of all on-site and off-site employees of Landlord or its agents, at the rank of property manager or below, engaged in operation, management,
administration, maintenance, repair and security of the Real Property, including, without limitation, administrative, management and accounting personnel and the individual(s) responsible for management of the Property, and payroll, social security,
workers‘ compensation, unemployment and similar taxes with respect to such employees of Landlord or its agents, and the cost of providing disability or other benefits imposed by law or otherwise, with respect to such employees; (iv) costs of
all supplies, materials and equipment rentals used in operations; (v) all maintenance, janitorial, security and service costs; (vi) a management fee not to exceed 5% of all gross revenues from the Real Property, including revenues attributable to
Tenant’s and other tenants’ payments of Operating Expenses; (vii) legal and accounting expenses, including the cost of audits by certified public accountants; (viii) all repair, painting and maintenance costs relating to the Real Property
and its Common Areas, including sidewalks, landscaping, service areas, mechanical rooms, parking areas, Building exterior and driveways; (ix) all charges for heat, water, gas, steam, fuel, electricity and other utilities used or consumed in the
Buildings and Common Areas; (x) costs of repairs, replacements, and general maintenance to and of the Building Systems and the Base Building Components (as such terms are defined in Sections 9.a. and 10.a.; respectively, below); (xi) the costs of
capital improvements, capital replacements, capital repairs, capital equipment, and capital tools and devices installed or paid for by Landlord and intended to reduce other Operating Expenses or required to comply with Legal Requirements (as defined
in Section 8.c. below) or intended for the protection of the health and safety of the occupants of the Property; and (xii) the cost of furniture, draperies, carpeting, and other items of personal property (excluding paintings, sculptures and other
works of art) provided by Landlord for use in the Common Areas, or the Building office (to the extent that such Building office is dedicated to the operation and management of the Property). With respect to any costs included in Operating Expenses
under clauses (viii) or (x) which are capital expenditures, as determined by Landlord in accordance with generally accepted accounting principles consistently applied, and with respect to the costs of items included in Operating Expenses under
clause (xi), such costs shall be amortized over a period determined by Landlord, together with interest on the unamortized balance at a rate per annum equal to three (3) percentage points over the Treasury Rate charged at the time such item is
constructed or acquired, or at such higher rate as may have been paid by Landlord on funds borrowed for the purpose of acquiring or constructing such item, but in either case not more than the maximum rate permitted by law at the time such item is
acquired or constructed. As used herein, “Treasury Rate” means the six-month United States treasury bill rate in effect from time to time by the San Francisco Main Office of Bank of America, NA (or any successor bank thereto), or if there
is no such rate, the rate quoted by such bank in pricing ninety day commercial loans to substantial commercial borrowers. 
  
 Operating Expenses shall not include the following: (i) depreciation on the Buildings or equipment or systems therein; (ii) debt service; (iii)
rental under any ground or underlying lease; (iv) attorneys’ fees and expenses incurred in connection with negotiations or disputes with past, current or prospective Building tenants, lenders, purchasers or ground lessors; (v) the cost of
decorating, improving for tenant occupancy, painting or redecorating portions of the Buildings to be demised to tenants; (vi) advertising expenses; (vii) costs reimbursed by insurance proceeds; or (viii) real estate broker’s or other leasing
commissions. 
  
 The parties agree that statements in this
Lease to the effect that Landlord is to perform certain of its obligations hereunder at its own or sole cost and/or expense shall not be interpreted as excluding any cost from Operating Expenses if such cost is an Operating Expense pursuant to the
terms of this Section 5.b. 
  
 c. Monthly Adjustment. Promptly
following the commencement of the Term and prior to the commencement of each subsequent calendar year (or as soon thereafter as practicable), Landlord shall estimate the Operating Expenses payable by Tenant for such calendar year pursuant to this
Section. Tenant shall pay to Landlord, on the first day of each month, in advance, one-twelfth (1/12) of Landlord’s estimated amount. If at any time during the course of the year Landlord determines that the Operating Expenses 

  

 3 

 
payable by Tenant will vary from the then estimated amount, by notice to Tenant Landlord may revise the amount payable by Tenant during the balance of the calendar
year such that the total estimated additional amount due from Tenant for such calendar year is paid by Tenant during the balance of the calendar year in equal monthly amounts. Within ninety (90) days (or as soon thereafter as practicable) after the
close of each calendar year, Landlord shall provide Tenant with a statement to account for any difference between the actual and the estimated Operating Expenses for the previous year. Landlord’s annual statement shall be final and binding upon
Landlord and Tenant unless, within ninety (90) days after delivery thereof to Tenant, Landlord shall revise or Tenant shall contest any item therein by written notice to the other, specifying each item revised or contested and the reason therefor.
Notwithstanding the foregoing, the Real Property Taxes included in any such annual statement may be modified by any subsequent adjustment or retroactive application of Real Property Taxes affecting the calculation of Operating Expenses. If Tenant
has overpaid the amount of Operating Expenses owing pursuant to this Section, Landlord shall credit the overpayment against Tenant’s next payments due under this Section 5. If Tenant has underpaid the amount of Operating Expenses owing pursuant
to this Section, Tenant shall pay the amount of the underpayment to Landlord within thirty (30) days after Tenant’s receipt of Landlord’s statement. If the rentable area of the Building is not fully occupied during any calendar year,
Operating Expenses for such calendar year shall be adjusted to equal Landlord’s reasonable estimate of the Operating Expenses which would have been incurred during such calendar year if the total rentable area of the Building were occupied.

  
 d. Definition of Real Property Taxes. The term “Real
Property Taxes” shall mean any ordinary or extraordinary form of assessment or special assessment, license fee, rent tax, levy, penalty (if a result of Tenant’s delinquency), or tax (other than net income, estate, succession, inheritance,
transfer or franchise taxes), imposed by any authority having the direct or indirect power to tax, or by any city, county, state or federal government for any maintenance or improvement or other district or division thereof. The term shall include
all transit charges, housing fund assessments, real estate taxes and all other taxes relating to the Premises, Building and/or Property, all other taxes which may be levied in lieu of real estate taxes, all assessments, assessment bonds, levies,
fees, and other governmental charges (including, but not limited to, charges for traffic facilities, improvements, child care, water services studies and improvements, and fire services studies and improvements) for amounts necessary to be expended
because of governmental orders, whether general or special, ordinary or extraordinary, unforeseen as well as foreseen, of any kind and nature for public improvement, services, benefits or any other purposes which are assessed, levied, confirmed,
imposed or become a lien upon the Premises, Building or Property or become payable during the Term. 
  
 e. Acknowledgment of Parties. It is acknowledged by Landlord and Tenant that Proposition 13 was adopted by the voters of the State of California in the June,
1978 election, and that assessments, taxes, fees, levies and charges may be imposed by governmental agencies for such purposes as fire protection, street, sidewalk, road, utility construction and maintenance, refuse removal and for other
governmental services which formerly may have been provided without charge to property owners or occupants. It is the intention of the parties that all new and increased assessments, taxes, fees, levies and charges due to Proposition 13 or any other
cause are to be included within the definition of Real Property Taxes for purposes of this Lease. 
  
 f. Taxes on Tenant Improvements and Personal Property. Notwithstanding any other provision hereof, Tenant shall pay the full amount of any increase in Real
Property Taxes during the Term resulting from any and all Alterations (as defined in Section 9.a. below) of any kind whatsoever placed in, on or about the Premises for the benefit of, at the request of, or by Tenant. Tenant shall pay, prior to
delinquency, all taxes assessed or levied against Tenant’s personal property, equipment, furniture or trade fixtures (collectively, “Personal Property”) in, on or about the Premises. When possible, Tenant shall cause its Personal
Property to be assessed and billed separately from the real or personal property of Landlord. Tenant recognizes that pursuant to Section 107.6 of the California Revenue and Taxation Code Tenant’s possessory interest under this Lease may be
subject to property taxation based on the full cash value, as defined in Sections 110 and 110.1 of the California Revenue and Taxation Code. 
  

 4 

 g. Fiscal Year. Landlord shall have the right to account and bill for Operating Expenses on the basis of a
fiscal year, rather than a calendar year as set forth above, and to revise such fiscal year from time to time, provided that Landlord follows generally accepted accounting principles consistently applied in connection therewith. 
  
 h. Net Lease. This shall be a Net Lease and Base Rent shall be paid to Landlord
absolutely net of all costs and expenses except as expressly herein provided. The provisions for Tenant’s payment of Tenant’s Percentage Share of Operating Expenses are intended to pass on to Tenant and reimburse Landlord for Tenant’s
Percentage Share of all costs and expenses associated with the Real Property, except as expressly provided in this Lease. 
  
 6. Proration of Rent. If the Commencement Date is not the first day of a calendar month, or if the end of the Term is not the last day of a calendar month, Base Rent
payable by Tenant pursuant to Section 4, and Operating Expenses payable by Tenant pursuant to Section 5, shall be prorated on a daily basis (based upon a thirty (30) day month) for such fractional month. If any date on which Base Rent is to be
adjusted hereunder is not the first day of a calendar month, Base Rent payable by Tenant pursuant to Section 4 for such calendar month shall be prorated on a daily basis (based on the number of days in such month) to take into account the differing
Base Rent rates. The termination of this Lease shall not affect the obligations of Landlord and Tenant pursuant to Section 5.c. which are to be performed after the termination. 
  
 7. Premises As-Is. The Premises shall be delivered to Tenant in its then “as-is” condition, and Landlord shall not have any
obligation to make or, except as provided below in this Section 7, pay for any alterations, additions, improvements or repairs to prepare the Premises for Tenant’s occupancy. 
  
 Landlord acknowledges that Tenant intends to perform certain Alterations to prepare the Premises for Tenant’s
initial occupancy. Such Alterations shall be performed subject to the provisions of Section 9 below. Notwithstanding the foregoing provisions, upon Tenant’s request Landlord shall advance to Tenant up to $155,000.00 (which is $10.00 per
rentable square foot of the Premises) towards the cost of such initial Alterations. The amount so advanced by Landlord (the “Improvement Advance”) shall be repaid by Tenant, together with interest on amounts thereof from time to time
unpaid at the rate of eleven percent (11%) per annum, in equal monthly installments of principal and interest, as additional rent hereunder, payable with the monthly Basic Rent. Such installments shall be in such amount as will fully amortize the
amount of the Improvement Advance, together with such interest, over the initial Term. Upon the determination of the amount of the Improvement Advance, Landlord and Tenant shall promptly execute a written memorandum of the amount of such
installments. Notwithstanding anything in the foregoing to the contrary, in the event this Lease is terminated prior to the originally scheduled Expiration Date, for any reason whatsoever, the then-outstanding balance of Improvement Advance,
together with accrued and unpaid interest thereon, but without any prepayment penalty, shall become immediately due and payable in full by Tenant. 
  
 8. Use of the Premises. 
  
 a. Use. The Premises shall be used solely for the use set forth in the Basic Lease Information and for no other use or purpose; provided, however, that
Landlord agrees that incidental to Tenant’s permitted use of the Premises as set forth in the Basic Lease Information, Tenant may conduct animal testing, limited to small rodents and guinea pigs, provided that such activity is conducted in
compliance with all applicable Legal Requirements and Tenant has obtained all necessary governmental and quasi-governmental permits required in connection therewith. In the event that any such activity by Tenant shall give rise to a disturbance
(including any picket or demonstration) on or about the Premises or the Property, Tenant shall immediately use its best efforts to eliminate such disturbance, and if Tenant’s discontinuance of animal testing is necessary to eliminate such
disturbance, Tenant shall discontinue animal testing and 

  

 5 

 
remove all animals from the Premises within six (6) months from Landlord’s notice thereof to Tenant. Notwithstanding the foregoing, if the disturbance at issue is
one which interferes with another tenant’s access to or quiet enjoyment of its premises in the Property, and by reason thereof might subject Landlord to liability to such tenant or entitle such tenant to terminate its lease or reduce the rent
payable thereunder, Tenant shall cause such disturbance to be immediately eliminated, and if Tenant’s discontinuance of animal testing is necessary to immediately eliminate such disturbance, Tenant shall immediately discontinue animal testing
and remove all animals from the Premises. Tenant shall not do or suffer or permit anything to be done in or about the Premises or the Real Property which will in any way obstruct or interfere with the rights of other tenants or occupants of the
Building or injure or annoy them, or use or suffer or permit the Premises to be used for any immoral, unlawful or objectionable purpose, nor shall Tenant cause, maintain, suffer or permit any nuisance in, on or about the Premises or the Real
Property. Without limiting the foregoing, Tenant shall not permit any odors, smoke, dust, gas, substances, noise or vibration to emanate from the Premises, and no loudspeakers or other similar device which can be heard outside the Premises shall,
without the prior written approval of Landlord, be used in or about the Premises. Tenant shall not commit or suffer to be committed any waste in, to or about the Premises. Tenant agrees not to employ any person, entity or contractor for any work in
the Premises (including moving Tenant’s equipment and furnishings in, out or around the Premises) whose presence may give rise to a labor or other disturbance in the Building and, if necessary to prevent such a disturbance in a particular
situation, Landlord may require Tenant to employ union labor for the work. 
  
 b. Rules and Regulations; CC&R’s. Tenant shall comply with the Rules and Regulations attached hereto as Exhibit C, as the same may be modified from time to time by Landlord (provided such modifications do not preclude
Tenant’s use of the Premises as permitted hereby) upon prior notice to Tenant (the “Rules”). In addition, Tenant shall comply with any covenants, conditions and restrictions (“CC&R’s” ) applicable to the Real
Property, and all rules, regulations and restrictions imposed by any association formed pursuant to the CC&R’s, in each case to the extent Landlord has delivered a copy thereof to Tenant and the same are not in conflict with the provisions
of this Lease. Landlord shall not amend or otherwise modify the CC&R’s so as to preclude Tenant’s use of the Premises as permitted hereby, diminish Tenant’s rights under this Lease or increase Tenant’s obligations under this
Lease. In the case of any conflict or inconsistency between the Rules and the balance of this Lease, the balance of this Lease shall control. 
  
 c. Compliance. Tenant shall not permit the Premises to be used in violation of or in conflict with, and at its sole cost and expense shall promptly comply
with, all laws, statutes, ordinances and governmental rules, regulations or requirements now in force or which hereinafter may be in force, with the requirements of any board of fire underwriters or other similar board now or hereafter constituted,
with any direction or occupancy certificate issued pursuant to any law by any public officer or officers, as well as the provisions of all recorded documents affecting the Premises (all of the foregoing, collectively, “Legal
Requirements”), insofar as any thereof relate to or affect the condition, use or occupancy of the Premises, and Tenant shall perform all work to the Premises and other portions of the Real Property required to effect such compliance (or, at
Landlord’s election, Landlord may perform such work at Tenant’s expense). The judgement of any court of competent jurisdiction or the admission of Tenant in any actions against Tenant, whether Landlord be a party thereto or not, that
Tenant has so violated any such law, statute, ordinance, rule, regulation or requirement, shall be conclusive of such violation as between Landlord or Tenant. 
  

d. Hazardous Materials. Tenant shall not cause or permit the storage, use, generation, release, handling or disposal (collectively, “Handling”)
of any Hazardous Materials (as defined below), in, on, or about the Premises or the Real Property by Tenant or any agents, employees, contractors, licensees, subtenants, customers, guests or invitees of Tenant (collectively with Tenant, “Tenant
Parties”), except that Tenant shall be permitted to use in the Premises in a normal and customary manner (i) normal quantities of office supplies or products (such as copier fluids or cleaning supplies) customarily used in the conduct of
general business office activities (“Common Office Chemicals”) and (ii) normal quantities of other 

  

 6 

 
Hazardous Materials customarily used in the conduct of the other uses of the Premises as permitted hereunder (“Permitted Haz Mats”), provided that the
Handling of such Common Office Chemicals and Permitted Haz Mats shall comply at all times with all Legal Requirements, including Hazardous Material Laws (as defined below). Prior to the Commencement Date, and thereafter upon Landlord’s request
from time to time, Tenant shall provide to Landlord a complete written inventory of all Hazardous Material which Tenant anticipates using or storing on, or discharging from , the Premises along with copies of all reports, permits and business plans
filed with any federal, state, local or other governmental agency. Tenant shall update the inventory in January of each calendar year, and as more frequently required to reflect any material changes to the items required to be disclosed therein.
Tenant shall be solely responsible for and shall indemnify, defend and hold Landlord and all other Indemnitees (as defined in Section 13.a. below), harmless from and against all Claims (as defined in Section 13.a. below), arising out of or in
connection with, or otherwise relating to (i) any Handling of Hazardous Materials by any Tenant Party or Tenant’s breach of its obligations hereunder, or (ii) any removal, cleanup, or restoration work and materials necessary to return the Real
Property or any other property of whatever nature located on the Real Property to their condition existing prior to the Handling of Hazardous Materials in, on or about the Premises by any Tenant Party. Tenant shall promptly provide Landlord with
copies of all notices received by it, including, without limitation, any notice of violations, notice of responsibility or demand for action from any federal, state or local authority or official in connection with the presence of Hazardous
Materials in or about the Premises or any other portion of the Property. In the event of any release of Hazardous Materials upon the Premises or any other portion of the Property, or upon adjacent lands, if caused by Tenant or any other Tenant
Party, Tenant shall promptly remedy the problem in accordance with all applicable Legal Requirements. For purposes of this Lease, “Hazardous Materials” means any explosive, radioactive materials, hazardous wastes, or hazardous substances,
including without limitation asbestos containing materials, PCB’s, CFC’s, or substances defined as “hazardous substances” in the Comprehensive Environmental Response, Compensation and Liability Act of 1980, as amended, 42 U.S.C.
Section 9601-9657; the Hazardous Materials Transportation Act of 1975, 49 U.S.C. Section 1801-1812; the Resource Conservation and Recovery Act of 1976, 42 U.S.C. Section 6901-6987; or any other Legal Requirement regulating, relating to, or imposing
liability or standards of conduct concerning any such materials or substances now or at any time hereafter in effect (collectively, “Hazardous Materials Laws”). Tenant’s obligations under this Section 8.d. shall survive the expiration
or other termination of this Lease. 
  
 e. Quiet Enjoyment. If, and
so long as, Tenant pays the Rent and keeps, observes and performs each and every term, covenant and condition of this Lease on the part or on behalf of Tenant to be kept, observed and performed, Tenant shall peaceably and quietly enjoy the Premises
throughout the Term without hindrance by Landlord or any person lawfully claiming through or under Landlord, subject to the provisions of this Lease (including, without limitation, the provisions of Section 22 below and the prior rights of Ground
Lessors and Holders). 
  
 9. Alterations. 
  
 a. Alterations. Tenant shall not make any alteration, addition or improvement
in, to or upon the Premises (“Alteration”) without the prior written consent of Landlord in each instance, which consent shall not be unreasonably withheld with respect to proposed Alterations which (i) are not structural in nature, (ii)
do not affect the Base Building Components, (iii) are, in Landlord’s opinion, compatible with the Building and the balance of the Real Property and the Building’s mechanical, plumbing, electrical, heating/ventilation/air conditioning,
communication, security and fire and other life safety systems (collectively, the “Building Systems”), and (iv) in Landlord’s opinion will not interfere with the use and occupancy of any other portion of the Building or the Real
Property by any other tenant or permitted occupant thereof. Tenant shall give Landlord not less than ten (10) days’ prior written notice of any Alteration Tenant desires to make. Any Alterations as to which Landlord shall consent shall be made
only by contractors approved in advance, in writing by Landlord, which approval shall not be unreasonably 

  

 7 

 
withheld; provided, however, that Landlord may, in its sole discretion, specify the engineers and contractors to perform any work relating to or affecting the Building
Systems or the Base Building Components. Tenant shall comply with all Legal Requirements applicable to each Alteration and shall deliver to Landlord complete set of “as built” plans and specifications for each Alteration. Any work to the
balance of the Building or Real Property related to or affected or triggered by Tenant’s Alterations shall be performed by Tenant at Tenant’s expense (or, at Landlord’s election, Landlord may perform such work at Tenant’s
expense). Tenant shall be solely responsible for maintenance and repair of all Alterations made by Tenant. Tenant shall pay Landlord on demand (whether prior to or during the course of construction) an amount (the “Alteration Fee”) equal
to five percent (5%) of the first One Hundred Thousand Dollars ($100,000.00) of the total cost of each Alteration and two and one-half percent (2 1/2%) of the portion of the total cost of each Alteration in excess of One Hundred Thousand Dollars
($100,000.00) (and for purposes of calculating the Alteration Fee, such cost shall include architectural and engineering fees, but shall not include permit fees) as compensation to Landlord for miscellaneous costs incurred by Landlord in connection
with the Alteration. In addition, Tenant shall reimburse Landlord for all third party fees paid by Landlord in connection with reviewing the proposed Alterations (whether or not the proposed Alterations are ultimately approved by Landlord or made by
Tenant), including, without limitation, Landlord’s architectural and engineering fees. All Alterations shall be performed diligently and in a first-class workmanlike manner and in accordance with plans and specifications approved by Landlord,
and shall comply with Landlord’s construction procedures and requirements for the Building (including Landlord’s requirements relating to insurance and contractor qualifications and scheduling of the work). 
  
 b. Liens. If, because of any act or omission of Tenant or anyone claiming by,
through, or under Tenant, any mechanic’s lien or other lien is filed against the Premises or any other portion of the Real Property or against other property of Landlord (whether or not the lien is valid or enforceable), Tenant shall, at its
own expense, cause it to be discharged of record within a reasonable time, not to exceed ten (10) days, after the date of the filing. In addition, Tenant shall defend and indemnify Landlord and hold it harmless from any and all Claims resulting from
the lien. Without limitation of Landlord’s other remedies, Landlord shall have the rights under Section 16 below if any such lien is not timely discharged by Tenant. 
  
 c. Ownership of Alterations. All Alterations (including, without limitation, any benches placed in the Premises by Tenant, but
excluding any chemical fume hoods now in the Premises or hereafter placed in the Premises by Tenant) shall immediately become Landlord’s property. Except as provided in Section 9.d., Landlord may require Tenant, at Tenant’s sole expense
and by the end of the Term, to remove any Alterations and to restore the Premises to its condition prior to the Alteration. Nothing contained in this Lease shall give Landlord any ownership rights in or to Tenant’s Personal Property (as defined
in Section 7.f.) or any chemical fume hoods now in the Premises or hereafter placed in the Premises by Tenant, all of which shall be and remain Tenant’s property (subject to the provisions of Section 15.b.(ii)). Landlord acknowledges that
Tenant intends to remove any or all of the chemical fume hoods located in the Premises as of the date of this Lease, and that Tenant shall not be required to replace said hoods upon the expiration or earlier termination of this Lease. 
  
 d. Request Regarding Removal Obligation. At the time that Tenant requests
Landlord’s consent to any Alteration, Tenant may request that Landlord notify Tenant if Landlord will require Tenant, at Tenant’s sole expense, to remove any or all of the Alteration by the end of the Term, and to restore the Premises to
its condition prior to the Alteration. Unless Landlord shall have expressly agreed in writing not to require such removal and restoration, Landlord’s election right under Section 9.c. shall continue through the end of the Term as to such
Alterations. Without limitation, the foregoing election right shall apply to any wires, cables, conduit or similar equipment placed by Tenant in or upon the Building or the Premises. 
  

 8 

 10. Repairs. 
  
 a. Landlord’s Repairs. Landlord shall maintain the roof, foundations, floor slabs and exterior walls of the Building (collectively, the “Base
Building Components”) in good condition and repair, reasonable wear and tear excepted. The term walls as used herein shall not include windows, glass or plate glass, doors, special store fronts or office entries. The term roof as used herein
shall not include skylights, smoke hatches or roof vents. Landlord shall also maintain in good condition and repair, reasonable wear and tear excepted, the Common Areas, including, but not limited to, the landscaped areas, parking areas and
driveways. Tenant shall reimburse Landlord for Landlord’s costs of complying with its obligations under this Section 10 in accordance with Section 5 above, provided, however, that any damage caused by or repairs necessitated by any act of
Tenant or any other Tenant Party may be repaired by Landlord at Landlord’s option and at Tenant’s expense. Tenant shall give Landlord prompt written notice of any repairs required of Landlord pursuant to this Section 10, after which notice
Landlord shall perform the same with reasonable diligence. In addition to the foregoing, Landlord shall, at Tenant’s direct expense (and not as an Operating Expense), enter into a regularly scheduled preventive maintenance/service contract with
a maintenance contractor for servicing all hot water, heating and air conditioning systems and equipment within or serving the Premises, and Tenant shall reimburse Landlord for all such expenses within thirty (30) days after Landlord’s demand.

  
 b. Tenant’s Repairs. Tenant shall, at Tenant’s expense,
maintain all parts of the Premises in a good, clean and secure condition, promptly making all necessary repairs and replacements including, but not limited to, all windows, glass or plate glass, doors and any special store fronts or office entries,
walls and wall finishes, floor covering, Building Systems, truck doors, dock bumpers, dock plates and levelers, plumbing work and fixtures, downspouts, skylights, smoke hatches, roof vents and utility equipment, in each case to the extent the same
are located within or exclusively serve the Premises. Tenant shall, at Tenant’s expense, also perform necessary pest extermination and regular removal of trash and debris. Tenant shall not damage any demising wall or disturb the integrity and
support provided by any demising wall and shall, at its sole expense, immediately repair any damage to any demising wall caused by Tenant or its employees, agents or invitees or any other Tenant Party. Tenant hereby waives all right to make repairs
at the expense of Landlord or in lieu thereof to vacate the Premises and its other similar rights as provided in California Civil Code Sections 1932(1), 1941 and 1942 or any other Legal Requirement (whether now or hereafter in effect). 

 
 11. Damage or Destruction. 
  
 a. Landlord’s Obligation to Rebuild. If the Premises are damaged or
destroyed, Landlord shall promptly and diligently repair the Premises unless Landlord has the option to terminate this Lease as provided herein, and Landlord elects to terminate. 
  
 b. Right to Terminate. Landlord shall have the option to terminate this Lease if the Premises or the Building is destroyed or
damaged by fire or other casualty, regardless of whether the casualty is insured against under this Lease, if Landlord reasonably estimates that the repair of the Premises or the Building cannot be completed within ninety (90) days after the
casualty. Landlord shall also have the right to terminate this Lease if the repair is not fully covered by insurance maintained (or required to be maintained) by the Landlord pursuant to this Lease other than by reason of the deductible amounts
under Landlord’s insurance policies. Tenant shall have the option to terminate this Lease if the Premises is damaged or destroyed by fire or other casualty, and Landlord reasonably estimates that the repair of the Premises cannot be completed
within one (1) year after the casualty (except that if the fire or other casualty occurs during the last one (1) year of the Lease term, then a period of ninety (90) days shall be substituted for the aforesaid one (1) year period). Landlord shall
notify Tenant of Landlord’s reasonable repair period estimate within (60) days after the casualty. If a party desires to exercise the right to terminate this Lease as a result of a casualty, the party shall exercise the right by giving the
other party written notice of its election to terminate within thirty (30) days after delivery of Landlord’s repair period estimate, in which event this Lease shall 

  

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terminate fifteen (15) days after the date of the terminating party’s notice. If neither Landlord nor Tenant exercises the right to terminate this Lease, this
Lease shall continue in full force and effect and Landlord shall promptly commence the process of obtaining necessary permits and approvals, and shall commence repair of the Premises or the Building as soon as practicable and thereafter prosecute
the repair diligently to completion. 
  
 c. Limited Obligation to
Repair. Landlord’s obligation, should Landlord elect or be obligated to repair or rebuild, shall be limited to the Building shell. Tenant, at its option and expense, shall replace or fully repair all trade fixtures, equipment, Alterations
and other improvements installed by Tenant and existing at the time of the damage or destruction. 
  
 d. Abatement of Rent. In the event of any damage or destruction to the Premises which does not result in termination of this Lease, the Base Rent shall be
temporarily abated proportionately to the degree the Premises are untenantable as a result of the damage or destruction, commencing from the date of the damage or destruction and continuing during the period required by Landlord to substantially
complete its repair and restoration of the Premises; provided, however, that nothing herein shall preclude Landlord from being entitled to collect the full amount of any rent loss insurance proceeds. Tenant shall not be entitled to any compensation
or damages from Landlord for loss of the use of the Premises, damage to Tenant’s Personal Property or any inconvenience occasioned by any damage, repair or restoration. Tenant hereby waives the provisions of Section 1932, Subdivision 2, and
Section 1933, Subdivision 4, and Sections 1941 and 1942 of the California Civil Code, and the provisions of any similar Legal Requirement (whether now or hereafter in effect). 
  
 e. Insurance Proceeds. If this Lease is terminated, Landlord may keep all the insurance proceeds resulting from the damage
payable pursuant to insurance coverage maintained by Landlord, and Tenant shall have no claims thereto. 
  
 12. Eminent Domain. If all or any material part of the Premises or balance of the Real Property is taken for public or quasi-public use by a governmental authority under the power of eminent domain is conveyed to
a governmental authority in lieu of such taking (a “taking”), Landlord may terminate this Lease by written notice to Tenant within thirty (30) days after the taking. If all or any material part of the Premises is taken, and if the taking
causes the remaining part of the Premises to be untenantable an inadequate for use by Tenant for the purpose for which they were leased, then Tenant, at its option and by giving notice within fifteen (15) days after the taking, may terminate this
Lease as of the date Tenant is required to surrender possession of the Premises. If part of the Premises is taken but the remaining part is tenantable and adequate for Tenant’s use, then this Lease shall be terminated as to the part taken as of
the date Tenant is required to surrender possession, and, unless Landlord shall have terminated this Lease pursuant to the foregoing provisions, Landlord shall make such repairs, alterations and improvements as may be necessary to render the part
not taken tenantable, and the Base Rent shall be reduced in proportion to the part of the Premises taken. All compensation awarded for the taking shall be the property of Landlord without any deduction therefrom for any estate of Tenant, and Tenant
hereby assigns to Landlord all its right, title and interest in and to the award. Tenant shall have the right, however, to recover from the governmental authority, but not from Landlord, such compensation as may be awarded to Tenant on account of
the interruption of Tenant’s business, moving and relocation expenses and removal of Tenant’s Personal Property, provided that any such award to Tenant will not reduce the award which would otherwise be made to Landlord. 
  
 13. Indemnity and Insurance. 
  
 a. Indemnity. Tenant shall hold Landlord and its constituent shareholders,
partners, members or other owners, and all of their agents, contractors, servants, officers, directors, employees and licensees 

  

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(collectively with Landlord, the “Indemnitees”) harmless from and indemnify the Indemnitees against any and all claims, liabilities, damages, costs and
expenses, including reasonable attorneys’ fees and costs incurred in defending against the same (collectively, “Claims”), to the extent arising from (a) the acts or omissions of Tenant or any other Tenant Party in, on or about the
Real Property, or (b) any construction or other work undertaken by or on behalf of Tenant in, on or about the Premises, whether prior to or during the Term, or (c) any accident, injury or damage, howsoever and by whomsoever caused, to any person or
property, occurring in, on or about the Premises; except to the extent such Claims are caused by the negligence or willful misconduct of Landlord or any other Indemnitees or by Landlord’s breach of its obligations under this Lease. In case any
action or proceeding be brought against any of the Indemnitees by reason of any such Claim, Tenant, upon notice from Landlord, covenants to resist and defend at Tenant’s sole expense such action or proceeding by counsel reasonably satisfactory
to Landlord. The provisions of this Section 13.a. shall survive the expiration or earlier termination of this Lease with respect to any injury, illness, death or damage occurring prior to such expiration or termination. 
  
 b. Fire and Extended Coverage. Landlord shall procure and maintain in full force
and effect with respect to the Building a policy or policies of all risk insurance (including sprinkler, vandalism and malicious mischief coverage, and any other endorsements desired by the Landlord or required by the holder of any fee or leasehold
mortgage on the Real Property, but excluding, at Landlord’s option, the insurance described in Section 13.i. below) in such amount as Landlord shall determine, but in an amount at least equal to eighty percent (80%) (or such greater percentage
as shall be required to preclude Landlord from being deemed a coinsurer)) of the full replacement cost (including debris removal, and demolition, but excluding the land and the footings, foundations and installations below the basement level)
thereof, Such insurance, and all other insurance maintained by Landlord under this Lease, shall be for the sole benefit of Landlord, and the proceeds therefrom shall be under Landlord’s sole control. 
  
 c. Public Liability. Tenant, at its own cost and expense, shall keep and
maintain in full force and effect during the Term the following insurance coverages, written by an insurance company licensed by and admitted to issue insurance in the State of California, with a general policyholders’ rating of “A”
or better and a financial size ranking of “Class X” or higher, in the most recent edition of Best’s Insurance Guide, in the form customary to the locality, (i) commercial general liability insurance, including contractual liability
coverage, insuring Tenant’s activities with respect to the Premises and/or the Building against loss, damage or liability for personal injury or death of any person or loss or damage to property occurring in, upon or about the Premises, with a
minimum coverage of One Million Dollars ($1,000,000) per occurrence/Two Million Dollars ($2,000,000) general aggregate, plus a Five Million Dollar ($5,000,000) per occurrence/general aggregate umbrella, (ii) fire damage legal liability insurance and
personal/advertising injury insurance (which shall not be subject to the contractual liability exclusion), each in the minimum amount of One Million Dollars ($1,000,000), (iii) medical payments insurance in the minimum amount of Five Thousand
Dollars ($5,000), (iv) worker’s compensation insurance in statutory amounts, and (v) if Tenant operates owned, leased or non-owned vehicles on the Property, comprehensive automobile liability insurance with a minimum coverage of $1,000,000 per
occurrence/ Two Million Dollars ($2,000,000) general aggregate; provided, however, that if, at any time during the Term, Tenant shall have in full force and effect a blanket policy of public liability insurance with the same coverage for the
Premises as described above, as well as coverage of other premises and properties of Tenant, or in which Tenant has some interest, the blanket insurance shall satisfy the requirement hereof and be endorsed to separately apply to the Premises.

  
 d. Rental Abatement Insurance. Landlord may keep and maintain in
full force and effect during the Term rental abatement insurance against abatement or loss of rents with respect to the Real Property in such amount as determined by Landlord. 
  

 11 

 e. Insurance Certificates. Tenant shall furnish to Landlord, on or before the Commencement Date and
thereafter within thirty (30) days prior to the expiration of each policy, an original certificate of insurance issued by the insurance carrier of each policy of insurance carried by Tenant pursuant to this Section 13. The certificates shall
expressly provide that the policies shall not be cancelable or subject to reduction of coverage or otherwise be subject to modification except after thirty (30) days’ prior written notice to the parties named as insureds. Landlord, its
successors and assigns, and any nominee of Landlord holding any interest in the Premises, including, without limitation, any ground lessor or the holder of any fee or leasehold mortgage, shall be named as an additional insured under each policy of
insurance maintained by Tenant pursuant to this Lease. The policies and certificates shall further provide that the coverage shall be primary, and that any coverage carried by Landlord shall be secondary and noncontributory with respect to
Tenant’s policy. 
  
 f. Tenant’s Failure. If Tenant fails
to maintain any insurance required by this Lease, Tenant shall be liable for any loss or cost resulting from the failure. This Section shall not be deemed to be a waiver of any of Landlord’s rights and remedies under any other provision of this
Lease. 
  
 g. Waiver of Subrogation. Any policy or policies of fire,
extended coverage or similar casualty insurance which either party obtains in connection with the Building, the Premises, or Tenant’s Personal Property shall include a clause or endorsement denying the insurer any rights of subrogation against
the other party (and the other parties named as additional insureds pursuant to Section 13.e. above) to the extent rights have been waived by the insured prior to the occurrence of injury or loss. Landlord and Tenant each waives any rights of
recovery against the other (and the other parties named as additional insureds pursuant to Section 13.e. above) for injury or loss due to hazards insurable by policies of fire, extended coverage or similar casualty insurance, regardless of whether
such insurance policies or coverage shall actually have bee obtained by the party granting such waiver, and regardless of the cause of such fire or casualty, including the negligence of the party benefiting from such waiver. Because this Section
13.g will preclude the assignment of any claim mentioned in it by way of subrogation or otherwise to an insurance company or any other person, each party to this Lease agrees immediately to give to each of its insurance companies written notice of
the terms of the mutual waivers contained in this Section 13.g and to have the insurance policies properly endorsed, if necessary, to prevent the invalidation of the insurance coverages by reason of the mutual waivers contained in this Section 13.g.

  
 h. Tenant’s Property and Fixtures. Tenant shall assume the
risk of damage to any of Tenant’s furniture, equipment, machinery, goods, supplies or fixtures or other Personal Property, and to an Alterations which Tenant may make to the Premises, and shall insure the same throughout the Term, for their
full replacement cost, under insurance policies reasonably satisfactory to Landlord (certificates of which shall be delivered to Landlord as set forth above in Section 13.e). Tenant hereby releases Landlord from any obligation to insure the
foregoing items and from any liability for loss of or damage to such items regardless of cause. 
  
 i. Earthquake and Flood Insurance. In addition to any other insurance policies carried by Landlord in connection with the Building, Landlord may elect to
procure and maintain in full force and effect during the Term with respect to the Building a policy of earthquake/volcanic action and flood and/or surface water insurance, including rental value insurance against abatement or loss of rent in the
case of damage or loss covered under the earthquake/volcanic and flood and/or surface water insurance, in an amount up to one hundred percent (100%) of the full replacement cost (including debris removal and demolition) of the Building. 

 
 14. Assignment or Sublet. 
  
 a. Tenant shall not assign this Lease or sublet the Premises or any portion thereof
without the prior written consent of Landlord in each instance, which consent shall not, subject to Landlord’s rights under 

  

 12 

 
clause (i) below, be unreasonably withheld. If Tenant desires to assign this Lease or to sublet the Premises or any part thereof, Tenant shall give to Landlord written
notice of its intent at least sixty (60) days in advance of the date on which Tenant desires to assign or sublet the Premises, which notice shall designate the terms of the proposed assignment or sublet, the identity of the proposed assignee or
sublessee, and shall be accompanied by financial statements of such proposed assignee or sublessee and such other information regarding such party and its business and reputation as shall be required by Landlord to evaluate the proposed assignment
or sublet. Landlord shall have thirty (30) days after receipt of Tenant’s written notice and the above specified information within which to notify Tenant in writing that Landlord elects to (i) terminate this Lease, in the case of a proposed
assignment, or to terminate this Lease as to that portion of the Premises to be sublet, in the case of a proposed sublet, (ii) consent to the proposed assignment or sublet as described in Tenant’s notice, or (iii) reasonably refuse to consent
to Tenant’s proposed assignment or sublet, stating the reasons for such refusal. If Landlord fails to notify Tenant in writing of its election within the thirty (30) day period, Landlord shall be deemed to have made the election in clause (iii)
above. No consent by Landlord to any assignment or sublet shall be deemed to be a consent to a use not permitted under this Lease, to any act in violation of this Lease or to any subsequent assignment or sublet. No assignment or sublet by Tenant
shall relieve Tenant of any liability theretofore or thereafter arising under this Lease. An attempted assignment or sublet by Tenant in violation of the terms and covenants of this Section shall be void. 
  
 b. Processing Expenses. Tenant shall pay to Landlord, as Landlord’s cost of
processing each proposed assignment or subletting (whether or not the same is ultimately approved by Landlord or consummated by Tenant), an amount equal to the sum of (i) Landlord’s reasonable attorneys’ and other professional fees, plus (ii) the sum of $1000.00 for the cost of Landlord’s administrative, accounting an clerical time (collectively,
“Processing Costs”). Notwithstanding anything to the contrary herein, Landlord shall not be required to process any request for Landlord’s consent to an assignment or subletting until Tenant has paid to Landlord the amount of
Landlord’s estimate of the Processing Costs. When the actual amount of the Processing Costs is determined, it shall be reconciled with Landlord’s estimate, and an payments or refunds required as a result thereof shall promptly thereafter
be made by the parties. 
  
 c. Consideration to Landlord. In the
event of any assignment or sublease, whether or not requiring Landlord’s consent, Landlord shall be entitled to receive, as additional rent hereunder, seventy-five percent (75%) of any consideration (including, without limitation, payment for
leasehold improvements and an “Leasehold Profit” as defined below) in excess of the Assignment or Subletting Costs (as defined an amortized as set forth below) paid by the assignee or subtenant for the assignment or sublease and, in the
case of a sublease, Tenant shall pay to Landlord on a monthly basis seventy-five percent (75%) of the excess of the amount of rent and other consideration paid for the sublet space by the subtenant over the amount of monthly Base Rent and Operating
Expenses payable under this Lease and Assignment or Subletting Cos (amortized as set forth below), attributable to the sublet space for the corresponding month. “Assignment or Subletting Costs” shall mean, on an amortized basis over the
term of the sublease or assignment, an brokerage commissions paid by Tenant in connection with the subletting or assignment (not to exceed commissions typically paid in the market at the time of such subletting or assignment), Tenant’s
reasonable costs of advertising the space for sublease or assignment, and any improvement allowance paid by Tenant to the subtenant or assignee or any improvement costs paid by Tenant solely to prepare the space for the assignment or sublet,
provided that, as a condition to Tenant deducting the Assignment or Subletting Costs Tenant shall provide to Landlord, within sixty (60) days of Landlord’s execution of Landlord’s consent to the assignment or subletting, a detailed
accounting of the Assignment or Subletting Costs and supporting documents, such as receipts and construction invoices. “Leasehold Profit” shall be the value allocated to the leasehold between the parties to the assignment or sublease, but
in no event less than the excess of the present value of the fair market rent of the Premises for the remaining term of this Lease after sue assignment or sublease, over the Base Rent payable hereunder for such remaining term, as reasonable
determined by Landlord. Upon Landlord’s request, Tenant shall direct any subtenant or assignee to pay the 

  

 13 

 
directly to Landlord the amounts due to it pursuant to this Section 14.c. on account of such sublease assignment. If there is more than one sublease under this Lease,
the amounts (if any) to be paid by Tenant to Landlord pursuant to this Section 14.c. shall be separately calculated for each sublease and amounts due Landlord with regard to any one sublease may not be offset against rental and other consideration
pertaining to or due under any other sublease. 
  
 d. Documentation.
No permitted assignment or subletting by Tenant shall be effective until there been delivered to Landlord a fully executed counterpart of the assignment or sublease which expressly provides that (i) in the case of a sublease, the subtenant may not
assign its sublease or further sublet the sublet space without Landlord’s prior written consent, (ii) in the case of an assignment, the assignee assumes all of Tenant’s obligations under this Lease arising on or after the date of the
assignment, and (iii) in the case of a sublease, the subtenant agrees to be and remain jointly and severally liable with Tenant to Landlord for the payment of Rent pertaining to the sublet space in the amount set forth in the sublease, and for the
performance of all of the terms and provisions of this Lease pertaining to the sublet space. In addition to the foregoing, no assignment or sublease by Tenant shall be effective until there has been delivered to Landlord a fully executed counterpart
of Landlord’s consent to assignment or sublease form, as applicable. The failure or refusal of a subtenant or assignee to execute any such instrument shall not release or discharge the subtenant or assignee from its liability as set forth
above. Notwithstanding the foregoing, no subtenant or assignee shall be permitted to occupy the Premises unless and until such subtenant or assignee provides Landlord with certificates evidencing that such subtenant or assignee is carrying all
insurance coverage required of it under this Lease. 
  
 e. No Merger.
Without limiting any of the provisions of this Section 14, the voluntary or other surrender of this Lease by Tenant, or a mutual cancellation by Landlord and Tenant, shall not work a merger, and shall, at the option of Landlord, terminate all or any
existing subleases or subtenancies or, at the option of Landlord, operate as an assignment to Landlord of any or all such subleases or subtenancies. If Landlord does elect that such surrender or cancellation operate as an assignment of such
subleases or subtenancies, Landlord shall in no way be liable for any previous act or omission by Tenant under the subleases or for the return of any deposit(s) under the subleases that have not been actually delivered to Landlord, nor shall
Landlord be bound by any sublease modification(s) executed without Landlord’s consent or for any advance rental payment by the subtenant in excess of one month’s rent. 
  
 f. Indirect Assignments. For purposes of this Section 14, the following events shall be deemed an assignment or sublease, as
appropriate: (i) the issuance of equity interests (whether stock, partnership interests or otherwise) in Tenant or any subtenant or assignee, or any entity controlling any of them, to any person or group of related persons, in a single transaction
or a series of related or unrelated transactions, such that, following such issuance, such person or group shall have Control (as defined below) of Tenant or any subtenant or assignee; (ii) a transfer of Control of Tenant or any subtenant or
assignee, or any entity controlling any of them, in a single transaction or a series of related or unrelated transactions (including , without limitation, by consolidation, merger, acquisition or reorganization), except that the transfer of
outstanding capital stock or other listed equity interests by persons or parties other than “insiders” within ‘ the meaning of the Securities Exchange Act of 1934, as amended, through the “over-the-counter” market or any
recognized national or international securities exchange, shall not be included in determining whether Control has been transferred; (iii) a reduction of Tenant’s assets to the point that this Lease and/or other leases are substantially
Tenant’s only asset(s); or (iv) a change or conversion in the form of entity of Tenant , any subtenant or assignee, or any entity controlling any of them, which has the effect of limiting the liability of any of the partners, members or other
owners of such entity. “Control” shall mean direct or indirect ownership of 50% or more of all of the voting stock of a corporation or 50% or more of the voting legal equitable interest in any other business entity, or the power to direct
the management and operations of any entity (by equity ownership, contract or otherwise). 
  

 14 

 g. Affiliates; Successors. Notwithstanding anything to the contrary in Sections 14.a, 14.c. or 14.f., but
subject to the other provisions of this Section 14, Tenant may assign this Lease or sublet the Premise or any portion thereof, without Landlord’s consent, to any partnership, corporation or other entity which controls, is controlled by, or is
under common control with Tenant (control being defined for such purpose as ownership of 50% or more of all of the voting stock of a corporation or 50% or more of the voting legal or equitable interest in any other business entity, and the power to
direct the management and operations of the relevant entity) (an “Affiliate”) or to any partnership, corporation or other entity resulting from a merger or consolidation with Tenant or which acquires all or substantially all of
Tenant’s assets (through a transfer of assets or equity interests in Tenant) as a going concern and such assets include substantial assets other than this Lease (a “Successor”), provided that (i) Landlord receives at least ten (10)
days’ prior written notice of the assignment or subletting, in which Tenant shall expressly confirm that Tenant remains, primarily liable (together with the assignee in the event of an assignment) for all of the obligations of the Tenant under
this Lease, except that if such prior notice shall be prohibited under applicable Legal Requirements, then such notice shall be given as promptly as is permissible under applicable Legal Requirements, (ii) in the case of an assignment to a
Successor, the Successor’s net worth is not less than Tenant’s net worth immediately prior to such assignment (or series of transactions of which such assignment is a part), (iii) in the case of subletting or assignment to an Affiliate,
the Affiliate remains an Affiliate for the duration of the subletting or the balance of the term in the event of an assignment, (iv) Landlord receives a fully executed copy of the assignment or sublease agreement between Tenant and the Affiliate or
Successor at least ten (10) days prior to the effective date of such assignment or sublease, in which the Affiliate or Successor, as the case may be assumes (in the event of an assignment) all of Tenant’s obligations under this Lease, and
agrees (in the even of a sublease) that such subtenant will, at Landlord’s election, attorn directly to Landlord in the event that this Lease is terminated for any reason, except that if such prior delivery of the assignment or sublease shall
be prohibited under applicable Legal Requirements, then such delivery shall be made as promptly as is permissible under applicable Legal Requirements, (v) the use of the Premises will remain a use that is permitted under Section 8(a) of this Lease,
and (vi) in the case of an assignment, the essential purpose of such assignment is to transfer an active, ongoing business with substantial assets in addition to this Lease, and in the case of an assignment or sublease the transaction is for
legitimate business purposes unrelated to this lease and the transaction is not a subterfuge by Tenant to avoid it obligations under this Lease or the restrictions on assignment and subletting contained herein. 
  
 15. Default. 
  
 a. Tenant’s Default. A material breach of this Lease by Tenant shall, exist if any of the following events (severally,
“Event of Default”; collectively, “Events of Default”) shall occur: (i) if Tenant shall have failed to pay Base Rent, Tenant’s Percentage Share of increased Operating Expenses, or any other sum required to be paid hereunder
when due, including any interest due under Section 3; (ii) if Tenant shall have failed to perform any term, covenant or condition of this Lease except those requiring the payment of money, and Tenant shall have failed to cure the breach within
thirty (30) days after written notice from Landlord if the breach could reasonably be cured within the thirty (30) day period; provided, however, if the failure could not reasonably be cured within the thirty (30) day period, then Tenant shall not
be in default unless it has failed to promptly commence and thereafter continue to make diligent and reasonable efforts to cure the failure as soon as practicable as reasonably determined by Landlord; (iii) if Tenant shall have assign its assets for
the benefit of its creditors; (iv) if the sequestration of, attachment of, or execution on, any material part of the property of Tenant or on any property essential to the conduct of Tenant’s business shall have occurred, and Tenant shall have
failed to obtain a return or release of the property within thirty (30) days thereafter, or prior to sale pursuant to any sequestration, attachment or levy, whichever is earlier; (v) if Tenant shall have abandoned or vacated the Premises; (vi) if a
court shall have made or entered any decree or order adjudging Tenant to be insolvent, or approving as properly filed a petition seeking reorganization of Tenant, or directing the winding up or liquidation of Tenant, and the decree or order shall
have continued for a period of thirty (30) days; (vii) if Tenant shall make or suffer any transfer which constitutes a fraudulent 

  

 15 

 
or otherwise avoidable transfer under any provision of the federal Bankruptcy Laws or any applicable state law; or (viii) if Tenant shall have failed to comply with
the provisions of Sections 23 or 25 of this Lease within the time periods stated therein. An Event of Default shall constitute a default under this Lease. 
  
 b. Remedies Upon Tenant’s Default. Upon an Event of Default, Landlord shall have the following remedies, in addition to all other rights and remedies
provided by law, equity, statute or otherwise provided in this Lease, to which Landlord may resort cumulatively or in the alternative: 
  
 (i) Landlord has the remedy described in California Civil Code Section 1951.4 (a landlord may continue the lease in effect after the tenant’s
breach and abandonment and recover rent as it becomes due, if the tenant has the right to sublet and assign subject only to reasonable limitations), and may continue this Lease in full force and effect, and this Lease shall continue in full force
and effect as long as Landlord does not terminate Tenant’s right to possession, and Landlord shall have the right to collect Rent when due. During the period Tenant is in default, Landlord may enter the Premises and relet it, or any part of it,
to third parties for Tenant’s account, provided that any Rent in excess of the Rent due hereunder shall be payable to Landlord. Tenant shall be liable immediately to Landlord for all costs Landlord incurs in reletting the Premises, including,
without limitation, brokers’ commissions, expenses of cleaning and redecorating the Premises required by the reletting and like costs. Reletting may be for a period shorter or longer than the remaining Term of this Lease. Tenant shall pay to
Landlord the Rent and other sums due under this Lease on the dates the Rent is due, less the Rent and other sums Landlord receives from any reletting. No act by Landlord allowed by this Subsection (i) shall terminate this Lease unless Landlord
notifies Tenant in writing that Landlord elects to terminate this Lease. 
  
 (ii) Landlord may terminate Tenant’s right to possession of the Premises at any time by giving written notice to that effect. No act by Landlord other than giving written notice to Tenant of such termination shall
terminate this Lease. Acts of maintenance, efforts to relet the Premises or the appointment of a receiver on Landlord’s initiative to protect Landlord’s interest under this Lease shall not constitute a termination of Tenant’s right to
possession. On termination, Landlord shall have the right to remove all personal property of Tenant and store it at Tenant’s cost and to recover from Tenant as damages: (a) the worth at the time of award of unpaid Rent and other sums due and
payable which had been earned at the time of termination; plus (b) the worth at the time of award of the amount by which the unpaid Rent and other sums due and payable which would have been payable after termination until the time of award exceeds
the amount of the Rent loss that Tenant proves could have been reasonably avoided; plus (c) the worth at the time of award of the amount by which the unpaid Rent and other sums due and payable for the balance of the Term after the time of award
exceeds the amount of the Rent loss that Tenant proves could be reasonably avoided; plus (d) any other amount necessary to compensate Landlord for all the detriment proximately caused by Tenant’s failure to perform Tenant’s obligations
under this Lease, or which, in the ordinary course of things, would be likely to result therefrom, including, without limitation, any costs or expenses incurred by Landlord: (1) in retaking possession of the Premises, including reasonable
attorneys’ fees and costs therefor; (2) maintaining or preserving the Premises for reletting to a new tenant, including repairs or alterations to the Premises for the reletting; (3) leasing commissions; (4) any other costs necessary of
appropriate to relet the Premises; and (5) at Landlord’s election, such other amounts in addition to or in lieu of the foregoing as may be permitted from time to time by California Civil Code Section 1951.2 or any other laws of the State of
California. 
  
 The “worth at the time of award” of the amounts referred to in
Subsections (ii)(a) and (ii)(b) is computed by allowing interest at the lesser of eighteen percent (18%) per annum or the maximum rate permitted by law, on the unpaid Rent and other sums due and payable from the date due through the date of award.
The “worth at the time of award” of the amount referred to in Subsection (ii)(c) is computed by discounting the amount at the discount rate of the Federal Reserve Bank of San Francisco at the time of award, plus one percent (1%). Tenant
waives redemption or relief from forfeiture under California Code of Civil Procedure Sections 1174 and 1179, or under any other present or future law, if Tenant is evicted or Landlord takes possession of the Premises by reason of any default of
Tenant hereunder. 
  

 16 

 c. Landlord’s Default. Landlord shall not be deemed to be in default in the performance of any
obligation required to be performed by Landlord hereunder unless and until Landlord has failed to perform the obligation within thirty (30) days after receipt of written notice by Tenant to Landlord specifying the obligation Landlord has failed to
perform; provided, however, that if the nature of Landlord’s obligation is such that more than thirty (30) days are required for its performance, then Landlord shall not be deemed to be in default if Landlord shall commence the performance of
such obligation within the thirty (30) day period and thereafter shall diligently prosecute the same to completion. Notwithstanding the foregoing, in the case of emergency repairs required of Landlord pursuant to this Lease, Landlord shall exercise
reasonable diligence in the performance of such repairs. 
  
 16. Landlord’s Right
to Perform Tenant’s Covenants. 
  
 If Tenant shall at any time
fail to make any payment or perform any other act on its part to be made or performed under this Lease, Landlord may, but shall not be obligated to, make the payment or perform any other act to the extent Landlord may deem desirable and, in
connection therewith, pay expenses and employ counsel. Any payment or performance by Landlord shall not waive or release Tenant from any obligations of Tenant under this Lease. All sums so paid by Landlord, and all penalties, interest and costs in
connection therewith, shall be due and payable by Tenant on the next day after any payment by Landlord, together with interest thereon at the Interest Rate, from that date to the date of payment thereof by Tenant to Landlord, plus collection costs
and attorneys’ fees. Landlord shall have the same rights and remedies for the nonpayment thereof as in the case of default in the payment of Base Rent. 
  
 17. Letter of Credit. 
  
 a. Letter of Credit. Together with Tenant’s execution and delivery of this Lease to Landlord, Tenant shall deliver to Landlord the Letter of Credit
described below as security for Tenant’s performance of all of Tenant’s covenants and obligations under this Lease; provided, however, that neither the Letter of Credit nor any proceeds therefrom (the “Letter of Credit Proceeds”)
shall be deemed an advance rent deposit or an advance payment of any other kind, or a measure or limitation of Landlord’s damages or constitute a bar or defense to any of the Landlord’s other remedies under this Lease or at law upon
Tenant’s default. The Letter of Credit shall be maintained in effect from the date of this Lease through thirty (30) days after the expiration or earlier termination of the Term, and on or prior to the expiration of such thirty (30) day period,
Landlord shall return to Tenant the Letter of Credit (unless presented for payment as provided herein) and any Letter of Credit Proceeds then held by Landlord (other than those held for application by Landlord as provided below, including
application to cure any failure by Tenant to restore the Premises as required by this Lease upon the surrender thereof); provided, however, that in no event shall any such return be construed as an admission by Landlord that Tenant has performed all
of its obligations hereunder. Landlord shall not be required to segregate the Letter of Credit Proceeds from its other funds and no interest shall accrue or be payable to Tenant with respect thereto. Landlord may (but shall not be required to) draw
upon the Letter of Credit and use the Letter of Credit Proceeds or any portion thereof to cure any Event of Default by Tenant under this Lease or to compensate Landlord for any damage Landlord incurs as a result of Tenant’s failure to perform
any of its obligations hereunder, it being understood that any use of the Letter of Credit Proceeds shall not constitute a bar or defense to any of Landlord’s other remedies under this Lease. In such event and upon written notice from Landlord
to Tenant specifying the amount of the Letter of Credit Proceeds so utilized by Landlord and the particular purpose for which such amount was applied, Tenant shall immediately deliver to Landlord an amendment to the Letter of Credit or a replacement
thereof in an amount equal to one hundred percent (100%) of the amount specified below for the applicable period. Tenant’s failure to deliver such amendment or replacement to Landlord within five (5) days of Landlord’s notice shall 

  

 17 

 
constitute an Event of Default hereunder. No lessor under any ground or underlying lease or holder of or beneficiary under a mortgage or deed of trust, nor any
purchaser at any judicial or private foreclosure sale of the Property or any portion thereof, shall be responsible to Tenant for such Letter of Credit or any Letter of Credit Proceeds unless such lessor, holder or purchaser shall have actually
received the same. 
  
 b. As used herein, Letter of Credit shall mean an
unconditional, irrevocable letter of credit (hereinafter referred to as the “Letter of Credit”) issued at Tenant’s sole expense by the San Francisco office of a major national bank satisfactory to Landlord (the “Bank”),
naming Landlord as beneficiary, and in form and substance satisfactory to Landlord, in the amount of Six Hundred Seventy-Three Thousand Three Hundred Twenty Dollars ($673,320.00). The Letter of Credit shall be for a one-year or, at Tenant’s
election, longer, term and shall provide: (i) that Landlord may make partial and multiple draws thereunder, up to the face amount thereof, (ii) that Landlord may draw upon the Letter of Credit up to the full amount thereof, as determined by
Landlord, and the Bank will pay to Landlord the amount of such draw upon receipt by the Bank of a sight draft signed by Landlord and accompanied by a written certification from Landlord to the Bank stating either: (a) that an Event of Default has
occurred and is continuing under this Lease, or (b) that an uncured failure by the Tenant to perform one or more of its obligations has occurred under this Lease and there exist circumstances under which Landlord is enjoined or otherwise prevented
by operation of law from giving to Tenant a written notice which would be necessary for such failure of performance to constitute an Event of Default under this Lease, or (c) that Landlord has not received notice from the Bank that the Letter of
Credit will be renewed by the Bank for at least one (1) year beyond the then relevant expiration date and Tenant has not furnished Landlord with a replacement Letter of Credit as hereinafter provided, or (d) that Bank no longer meets the
requirements set forth above and Tenant has not furnished Landlord with a replacement Letter of Credit as required hereunder from a Bank meeting such requirements; and (iii) that, in the event of Landlord’s assignment or other transfer of its
interest in this Lease, the Letter of Credit shall be freely transferable by Landlord, without charge and without recourse, to the assignee or transferee of such interest and the Bank shall confirm the same to Landlord and such assignee or
transferee. The Letter of Credit shall further provide that a draw thereon pursuant to clause (ii)(c) above may only be made during the thirty (30) day period preceding the then applicable expiration date of the Letter of Credit. In the event that
the Bank shall fail to notify Landlord that the Letter of Credit will be renewed for at least one (1) year beyond the then applicable expiration date, and Tenant shall not have delivered to Landlord, at least thirty (30) days prior to the relevant
annual expiration date, a replacement Letter of Credit in the amount required hereunder and otherwise meeting the requirements set forth above, then Landlord shall be entitled to draw on the Letter of Credit as provided above, and shall hold and
apply the proceeds of such draw as Letter of Credit Proceeds pursuant to Paragraph 17.a above. 
  
 c. Notwithstanding the foregoing, in the event that Landlord shall be required to make the Improvement Advance described in Section 7 above, then the original amount of the Letter of Credit (or, if the Letter of Credit shall
have been drawn by Landlord, the balance of the Letter of Credit Proceeds then held by Landlord, as the case may be) shall be increased by the amount of the Improvement Advance within ten (10) days after determination of the amount of the
Improvement Advance to be advanced by Landlord. 
  
 In the event that Tenant
shall not deliver the Letter of Credit to Landlord in the form and amount required hereby on or prior to the date required hereby, then in lieu thereof Tenant shall deliver to Landlord cash in the amount of the so required Letter of Credit, and such
cash shall be held as Letter of Credit Proceeds in accordance with the foregoing provisions of this Section 17. If Tenant shall have delivered cash to Landlord in lieu of the Letter of Credit, Tenant shall substitute the Letter of Credit for such
cash within thirty (30) days after the date of this Lease, whereupon Landlord shall return such cash to Tenant. 
  

 18 

 18. Surrender of Premises. 
  

By taking possession of the Premises, Tenant shall be deemed to have accepted the Premises and the Property in good, clean and completed condition and repair,
subject to all applicable laws, codes and ordinances. On the Expiration Date or earlier termination of this Lease, Tenant shall surrender the Premises to Landlord in its condition as of the Commencement Date, normal wear and tear excepted. Tenant
shall remove from the Premises all of Tenant’s Personal Property and any Alterations required to be removed pursuant to Section 9 of this Lease. Tenant shall repair any damage or perform any restoration work required by the removal. If Tenant
fails to timely remove any Personal Property or Alterations as aforesaid, Landlord may remove the property and store and/or dispose of the same at Tenant’s expense, including interest at the Interest Rate. If the Premises are not so surrendered
at the termination of this Lease, Tenant shall indemnify Landlord against all Claims resulting from delay by Tenant in so surrendering the Premises, including, without limitation, any claims made by any succeeding tenant, losses to Landlord due to
lost opportunities to lease to succeeding tenants, and attorneys’ fees and costs. Tenant shall give written notice to Landlord at least thirty (30) days prior to vacating the Premises and shall meet with Landlord for a joint inspection of the
Premises at the time of vacating. In the event of Tenant’s failure to give such notice or participate in such joint inspection, Landlord’s inspection at or after Tenant’s vacating the Premises shall conclusively be deemed correct for
purposes of determining Tenant’s responsibility for removal of Alterations and repairs and restoration of the Premises. 
  
 19. Holding Over. 
  
 If Tenant remains in possession of all or any part of the Premises after the expiration of the Term or the earlier termination of this Lease without Landlord’s
prior written consent, the tenancy shall be a tenancy at sufferance only and shall not constitute a renewal or extension for any further term, regardless of whether Landlord shall accept Rent for any such period. In such event, Base Rent shall be
increased in an amount equal to the greater of (i) two hundred percent (200%) of the Base Rent during the last month of the Term (including any extensions), and (ii) two hundred percent (200%) of the fair market value of the Premises, and any other
sums due under this Lease shall be payable in the amount, and at the times, specified in this Lease. The tenancy shall be subject to every other term, condition, covenant and agreement contained in this Lease, except that any renewal or extension
option in favor of Tenant shall not be applicable. No such increase shall impair Landlord’s other rights and remedies against Tenant by reason of such holding over by Tenant, and Tenant shall vacate the Premises immediately upon Landlord’s
request. 
  
 20. Access to Premises. 
  
 Tenant shall permit Landlord and its agents to enter the Premises at all reasonable
times upon reasonable notice, except in the case of an emergency (in which event entry may be made when necessary and without notice), to inspect the Premises, to post Notices of Nonresponsibility and similar notices, to show the Premises to
interested parties such as prospective mortgagees, purchasers and tenants to provide any services required of Landlord hereunder, to make necessary alterations, additions, improvements or repairs either to the Premises, the Building, or other
premises within the Building, and to discharge Tenant’s obligations hereunder when Tenant has failed to do so within a reasonable time after written notice from Landlord. No such entry shall constitute a constructive eviction or give rise to an
abatement of Rent hereunder, constitute a constructive eviction, or otherwise diminish Tenant’s obligations under this Lease. In exercising its rights under this Section 20, Landlord shall at all times endeavor to minimize interference with
Tenant’s operations, to the extent practicable, and Tenant shall have the right to have an escort accompany Landlord and the other parties entering the Premises pursuant to this Section. During the last year of the Term, Landlord shall have the
right to erect on the exterior of the Premises and/or on the exterior or in the Common Areas of Building and the Property suitable signs indicating that the Premises are available for lease. 
  
 21. Signs. The size, design, color, location and other physical aspects of any sign in or
on the Premises shall be subject to the CC&R’s, Rules, Landlord’s approval prior to installation, and to all Legal Requirements. The costs of any permitted sign, and the costs of its installation, maintenance and removal, 

  

 19 

 
shall be at Tenant’s sole expense and shall be paid within ten (10) days of Tenant’s receipt of a bill from Landlord for the costs. In no event shall Tenant
be permitted to place any sign, logo or other identification on the exterior of the Building, in the Building’s Common Areas (other than on a Building directory maintained to identify the Building’s tenants), or upon the Property, or which
is inside the Premises but visible from outside of the Premises (other than upon the door(s) to the Premises). 
  
 22. Subordination. 
  
 a.
Subordinate Nature. Except as provided in Subsection b., this Lease is subject and subordinate to all ground and underlying leases, mortgages and deeds of trust which now or may hereafter affect the Real Property or any portion thereof, to
the CC&R’s, and to all renewals, modifications, consolidations, replacements and extensions of the foregoing, without the necessity of any further documentation evidencing such subordination. Notwithstanding such self-operative
subordination, within ten (10) days after Landlord’s written request therefor, Tenant shall execute any and all documents required by Landlord, the lessor under any ground or underlying lease (“Ground Lessor”), or the holder or
holders of any mortgage or deed of trust (“Holder”), evidencing this Lease to be subordinate to the lien of any such lease, mortgage or deed of trust, as the case may be. Tenant hereby irrevocably appoints Landlord as Tenant’s
attorney-in-fact to execute and deliver any such instrument in the name of Tenant if Tenant fails to do so within such time. If the interest of Landlord in the Real Property or the Building is transferred to any Ground Lessor or Holder pursuant to
or in lieu of proceedings for enforcement of any such lease, mortgage, or deed of trust, Tenant shall immediately and automatically attorn to the Ground Lessor or Holder, and this Lease shall continue in full force and effect as a direct lease
between the Ground Lessor or Holder and Tenant on the terms and conditions set forth herein. 
  
 b. Possible Priority of Lease. If a Ground Lessor or a Holder advises Landlord that it desires or requires this Lease to be prior and superior to a lease, mortgage or deed of trust, Landlord may notify Tenant. Within
seven (7) days of Landlord’s notice, Tenant shall execute, have acknowledged and deliver to Landlord any and all documents or instruments, in the reasonable form presented to Tenant, which Landlord, Ground Lessor or Holder deems necessary or
desirable to make this Lease, prior and superior to the lease mortgage or deed of trust. 
  
 c. Lease Modification. If, in connection with obtaining financing for the Real Property or any portion thereof, any Holder or Ground Lessor shall request reasonable modification to this Lease as a condition to such
ground lease or financing, Tenant shall execute and deliver to Landlord, within ten (10) days of Landlord’s request, any such modification agreement so requested, provided such modifications do not materially adversely affect Tenant’s
rights or materially increase Tenant’s obligations hereunder. 
  
 23. Transfer of
the Property. 
  
 Upon transfer of the Real Property and assignment
of this Lease, Landlord shall be entirely freed and relieved of all liability under any and all of its covenants and obligations contained in or derived from this Lease occurring after the consummation of the transfer and assignment. Landlord shall
transfer the Letter of Credit and the Letter of Credit Proceeds, if any, to the transferee of Landlord’s interest in the Real Property, and thereupon Landlord shall be released from all liability for the same. Tenant shall attorn to any entity
purchasing or otherwise acquiring the Premises at any sale or other proceeding. 
  
 24.
Estoppel Certificates: Financial Statements. 
  
 Within ten
(10) days following written request by Landlord from time to time throughout the Term, Ten shall execute and deliver to Landlord an estoppel certificate in the form prepared by Landlord. The certificate shall: (i) certify that this Lease is
unmodified and in full force and effect or, if modified, state the 

  

 20 

 
nature of the modification and certify that this Lease, as so modified, is in full force and effect, and the date to which the Rent and other charges are paid; (ii)
acknowledge that there are not, to Tenant’s best knowledge, any uncured defaults on the part of Landlord hereunder, or if there are uncured defaults on the part of the Landlord, state the nature of the uncured defaults; and (iii) set forth such
other matters regarding this Lease as may be reasonably required either by Landlord, any existing or prospective Ground Lessor or Holder, or a prospective purchaser of the Real Property from Landlord. At the request of Landlord from time to time
during the Term, Tenant shall provide to Landlord its current financial statements or other information setting forth Tenant’s financial condition and net worth. Landlord shall use such documentation solely for purposes of this Lease and in
connection with the ownership, financing, management and disposition of the Real Property. 
  
 25. Mortgagee Protection. 
  
 In the event of any
default on the part of Landlord, Tenant will give notice by registered or certified mail to each Ground Lessor and Holder whose identity has been disclosed to Tenant, and shall offer the Ground Lessor or Holder a reasonable opportunity after such
notice (but in no event less than thirty (30) days) to cure the default, including time to obtain possession of the Property or the Premises by lease termination, power of sale or a judicial foreclosure (as applicable), if such should prove
necessary to effect a cure. In no event shall any Ground Lessor or Holder in any way or to any extent be: (a) liable for any act or omission of any prior Landlord in contravention of any provision of this Lease; or (b) subject to any offsets, claims
or defenses which Tenant might have against any prior Landlord; or (c) bound by any Rent which Tenant might have paid for more than thirty (30) days in advance to any prior Landlord; or (d) bound by any agreement or modification of this Lease made
without such Ground Lessor’s or Holder’s written consent. Tenant agrees that if any Ground Lessor or Holder acquires possession of the Premises or title to the Real Property as a result of termination of its ground lease or foreclosure of
such Holder’s deed of trust or other security instrument, as applicable, the acceptance of a lease surrender or deed in lieu of such foreclosure, or otherwise, the provisions of Section 36 below shall be applicable to liability of such Ground
Lessor or Holder as successor Landlord under this Lease. 
  
 26. Attorneys’
Fees. 
  
 If either party shall bring any action or legal
proceeding for damages for an alleged breach of any provision of this Lease, to recover rent or other, sums due, to terminate the tenancy of the Premises or to enforce, protect or establish any term, condition or covenant of this Lease or right of
either party, the prevailing party shall be entitled to recover, as a part of the action or proceedings, or in a separate action brought for that purpose, reasonable attorneys’ fees and court costs as may be fixed by the court or jury. The
prevailing party shall be the party which secures a final judgment in its favor, provided that if the party bringing any action shall dismiss the same without the consent of the other party, the other party shall be deemed the prevailing party.

  
 27. Brokers. 
  
 Tenant warrants and represents that it has had no dealings with any real estate broker
or agent in connection with the negotiation of this Lease, and that it knows of no real estate broker or agent who is or might be entitled to a fee, commission or other compensation in connection with this Lease. Notwithstanding the foregoing,
Tenant acknowledges that CB Richard Ellis, Inc. (“CB”) may claim a commission or other compensation by reason of its alleged role in introducing Tenant to the Property and/or in consummating this Lease. Pursuant to the terms of a separate
agreement between Landlord and CB, Landlord has agreed to pay CB $25,000.00 (the “CB Settlement Amount”) in settlement of any claims CB may have against Landlord in connection with this Lease. Tenant shall pay (or cause to be paid) any
other commissions and fees owing to CB by reason of this Lease, and Tenant shall indemnify and hold harmless Landlord from and 

  

 21 

 
against any and all claims, liabilities or expenses (including reasonable attorneys’ fees and costs) (i) arising out of claims made by CB for commissions, fees or
other compensation in excess of the CB Settlement Amount, or (ii) arising out of claims made by any other broker or individual with whom Tenant has had any contact for a fee, commission or other compensation resulting from this Lease. 
  
 28. Parking. 
  
 Tenant shall have the right to park in the Building’s parking facilities, in common with other tenants of the Building, upon such
terms and conditions as may from time to time be established by Landlord. There shall be no charge for any portion of the parking facilities which is not reserved. Tenant shall have the right to use its proportionate share (i.e. the rentable square
footage of the Premises in proportion to the rentable square footage of the parking allocated to the Building) of the parking facilities, but in no event less than three (3) spaces per one thousand (1,000) rentable square feet of the Premises (as
rounded down to the nearest whole space). Tenant agrees not to use in excess of such proportionate share of parking facilities and further agrees to cooperate with Landlord and other tenants in the use of the parking facilities. Landlord reserves
the right, in its absolute discretion, to determine whether the parking facilities are becoming crowded and to allocate and assign parking spaces among Tenant and the other tenants, provided that Tenant shall be allocated and assigned its
proportionate share of the parking spaces. Landlord shall not be liable to Tenant, nor shall this Lease be affected, if any parking is impaired by moratorium, initiative, referendum, law, ordinance, regulation or order passed, issued or made by any
governmental or quasi-governmental body or by fire or other casualty. 
  
 29.
Utilities and Services. 
  
 Tenant shall arrange for all
telephone, water, gas, electricity and other power and utilities which it shall require in connection with its use or occupancy of the Premises and shall pay for the same, together with any taxes, penalties, surcharges or the like pertaining
thereto. In addition, Landlord shall have no obligation to furnish any utilities or services to the Premises or any equipment providing for the same. Without limitation, Tenant shall be solely responsible for providing such heating, ventilation and
air conditioning (“HVAC”) to the Premises as Tenant shall require for the comfortable occupancy thereof. Any equipment or systems which Tenant shall require in order to supply HVAC shall be subject to the provisions of Section 9 above.
Tenant shall obtain, at its expense all electric light bulbs, ballasts and tubes as it shall require for the Premises. If any of the foregoing utilities or services are not separately metered to Tenant, Tenant shall pay a reasonable proportion, as
determined by Landlord, of all charges jointly serving the Premises and other premises. Landlord shall not be liable for any damages directly or indirectly resulting from nor shall the Base Rent, Operating Expenses or any other monies owed by Tenant
to Landlord under this Lease be abated or reduced by reason of (a) the installation, use or interruption of use of any equipment used in connection with the furnishing of any of the foregoing utilities and services, (b) failure to furnish or delay
in furnishing any such utilities or services for any reason whatsoever, or (c) the limitation, curtailment, rationing or restriction on use of water, electricity, gas or any other form of energy or any other service or utility whatsoever serving the
Premises or the Real Property. Landlord shall be entitled to cooperate voluntarily and in a reasonable manner with the efforts of national, state or local government agencies or utility suppliers in reducing energy or other resource consumption. The
obligation to make services available hereunder shall be subject to the limitations of any such voluntary, reasonable program. 
  
 30. Investment Rights. 
  
 As partial consideration for Landlord entering into this Lease, Tenant has granted Landlord (or its designee) certain rights to purchase (the “Investment
Rights”) Tenant’s stock pursuant to a written agreement dated on or about the date of this Lease (the “Investment Agreement”). Landlord and Tenant agree that (i) the Investment Rights and the Investment Agreement (collectively,
the “Investment Documents”) are 

  

 22 

 
intended to be independent of this Lease and the landlord and tenant relationship created by this Lease, (ii) neither the Investment Documents, the grant or exercise
of the Investment Rights, nor the value of either collectively, the “Investment Consideration”) is intended to serve as any type or component of security for Tenant’s obligations or liabilities under this Lease, (iii) the Investment
Rights are exercisable absolutely independent of any obligation, liability; circumstance or event which may (or may not) arise under or in connection with this Lease, and in no event is the exercise of the Investment Rights by the holder thereof
contingent upon or in any way related to Tenant’s default under this Lease or the exercise (or non-exercise) of Landlord’s rights and remedies under this Lease, (iv) in no event is the exercise (or non-exercise) of Landlord’s rights
and remedies under this Lease contingent upon or in any way related to the exercise (or non-exercise) of the Investment Rights by the holder thereof, and (v) in no event shall the Investment Consideration be applied against or as a credit to the
rent or other charges or amounts due to Landlord under this Lease, including, without limitation, damages due to Landlord by reason of Tenant’s default hereunder. 
  
 31. Acceptance. 
  
 Delivery of this Lease, duly executed by Tenant, constitutes Tenant’s offer to lease the Premises as set forth herein, and under no circumstances shall such
delivery be deemed to create an option or reservation to lease the Premises for the benefit of Tenant. This Lease shall become effective and binding only upon execution hereof by Landlord and delivery of a signed copy to Tenant. If Landlord does not
accept the Tenant’s offer, any sums delivered by Tenant with its offer shall be returned to Tenant. 
  
 32. Use of Building Name. 
  
 Tenant
shall not employ the name of the Building in the name or title of its business or occupation, or for any other purpose, except to identify the address of the Building, without Landlord’s prior written consent, which consent Landlord may
withhold in its sole discretion. Landlord reserves the right to change the name of the Building without Tenant’s consent and without any liability to Tenant. 
  
 33. Recording. 
  
 Neither Landlord nor Tenant shall record this Lease, nor a short form memorandum of this Lease, without the prior written consent of the other. 
  
 34. Quitclaim. 
  
 Upon any termination or expiration of this Lease pursuant to its terms, Tenant, at Landlord’s request, shall execute, have
acknowledged and deliver to Landlord a quitclaim deed of all Tenant’s interest in the Premises, Building and Property created by this Lease. 
  
 35. Notices. 
  
 Any notice, demand or request required or desired to be given under this Lease shall be in writing sent to the address of the party specified in this Lease, and
shall be given by hand delivery, electronic mail (e.g., telecopy), overnight courier service (e.g. Federal Express), or the United States mail, registered or certified, the postage prepaid. All notices shall be deemed to have been given when
received at the address of the party to which it has been sent (or when such receipt is refused). As of the date of execution of this Lease, the addresses of Landlord and Tenant are as specified in the Basic Lease Information. Either party may
change its address by giving notice of the change in accordance with this Section. 
  

 23 

 36. Landlord’s Exculpation. 
  
 The term “Landlord,” as used in this Lease, shall mean only the owner or owners of the Real Property at the time in
question. Notwithstanding any other provision of this Lease, the liability of Landlord for its obligations under this Lease is limited solely to Landlord’s interest in the Real Property as the same may from time to time be encumbered, and no
personal liability shall at any time be asserted or enforceable against any other assets of Landlord or against the constituent shareholders, partners or other owners of Landlord, or the directors, officers, employees and agents of Landlord or such
constituent shareholder, partner or other owner, on account of any of Landlord’s obligations or actions under this Lease. Notwithstanding any other provision of this Lease, Landlord shall not be liable for any consequential damages or
interruption or loss of business, income or profits, nor shall Landlord be liable for loss of or damage to artwork, currency, jewelry, bullion, unique or valuable documents, securities or other valuables, or for other property not in the nature of
ordinary fixtures, furnishings and equipment. Wherever in this Lease Tenant (a) releases Landlord from any claim or liability, (b) waives or limits any right of Tenant to assert any claim against Landlord or to seek, recourse against any property of
Landlord or (c) agrees to indemnify Landlord against any matters, the relevant release, waiver, limitation or indemnity shall run in favor of and apply to Landlord, the constituent shareholders, partners or other owners of Landlord, and the
directors, officers, employees and agents of Landlord and each such constituent shareholder, partner or other owner. In no event shall any shareholder, partner, member, officer, director or other constituent of Landlord or its direct or indirect
constituents ever be personally liable for Landlord’s obligations or liability under this Lease. 
  
 37. Additional Structures. 
  
 Any
diminution or interference with light, air or view by any structure which may be erected on land adjacent to the Building shall in no way alter this Lease or impose any liability on Landlord. 
  
 38. Consents and Approvals. 
  
 Wherever the consent, approval, judgment or determination of Landlord is required or
permitted under this Lease, except as expressly provided herein Landlord may exercise its sole discretion in granting or withholding such consent or approval or in making such judgment or determination. Whenever Tenant requests Landlord to take any
action or give any consent or approval, Tenant shall reimburse Landlord for all of Landlord’s actual out-of-pocket costs incurred in reviewing the proposed action or consent (whether or not Landlord consents to any such proposed action),
including, without limitation, reasonable attorneys’ or consultants’ fees and expenses, within ten (10) days after Landlord’s delivery to Tenant of a statement of such costs. If it is determined that Landlord failed to give its
consent or approval where it was required to do so under this Lease, Tenant’s sole remedy will be an order of specific performance or mandatory injunction of the Landlord’s agreement to give its consent or approval. The review and/or
approval by Landlord of any item shall not impose upon Landlord any liability for accuracy or sufficiency of any such item or the quality or suitability of such item for its intended use. Any such review or approval is for the sole purpose of
protecting Landlord’s interest in the Real Property, and neither Tenant nor any Tenant Party nor any person or entity claiming by, through or under Tenant, nor any other third party shall have any rights hereunder by virtue of such review
and/or approval by Landlord. 
  
 39. General. 
  
 a. Captions. The captions and headings used in this Lease are for the purpose
of convenience only and shall not be construed to limit or extend the meaning of any part of this Lease. 
  
 b. Time. Time is of the essence for the performance of each term, condition and covenant of this Lease. 
  

 24 

 c. Severability. If any provision of this Lease is held to be invalid, illegal or unenforceable, the
invalidity, illegality, or unenforceability shall not affect any other provision of this Lease, but this Lease shall be construed as if the invalid, illegal or unenforceable provision had not been contained herein. 
  
 d. Choice of Law; Construction. This Lease shall be construed and enforced in
accordance with the laws of the State of California. The language in all parts of this Lease shall in all cases be construed as whole according to its fair meaning and not strictly for or against either Landlord or Tenant. 
  
 e. Gender; Singular, Plural. When the context of this Lease requires, the neuter
gender includes the masculine, the feminine, a partnership or corporation or joint venture, and the singular includes the plural. 
  
 f. Binding Effect. The covenants and agreements contained in this Lease shall be binding on the parties hereto and, subject to Section 14 above, on their
respective successors and assigns. 
  
 g. Waiver. The waiver of
Landlord of any breach of any term, condition or covenant of this Lease shall not be deemed to be a waiver of the provision or any subsequent breach of the same or any other term, condition or covenant of this Lease. The subsequent acceptance of
Rent hereunder by Landlord shall not be deemed to be a waiver of any preceding breach at the time of acceptance of the payment. No covenant, term or condition of this Lease shall be deemed to have been waived by Landlord unless the waiver is in
writing signed by Landlord. 
  
 h. Entire Agreement. This Lease is
the entire agreement between the parties, and supersedes all prior agreements, including letters of intent, between them, and there are no agreements or representations between the parties except as expressly set forth herein. Except as otherwise
provided herein, no subsequent change or addition to this Lease shall be binding unless in writing and signed by the parties hereto. 
  
 i. Waiver of Jury. Tenant hereby waives any right it may have to a jury trial in the event of litigation between Tenant and Landlord pertaining to this
Lease. Landlord and Tenant agree that this paragraph constitutes a written consent to waiver of trial by jury within the meaning of California Code of Civil Procedure Section 631(a)(2), and Tenant does hereby authorize and empower Landlord to file
this paragraph and or this Lease, as required, with the clerk or judge of any court of competent jurisdiction as a written consent to waiver of jury trial. 
  
 j. Counterparts. This Lease may be executed in counterparts, each of which shall be an original, an all of which together shall constitute but one
instrument. 
  
 k. Exhibits. The Basic Lease Information and all
exhibits attached hereto are hereby incorporated herein and made an integral part hereof. 
  
 l. Addendum. The Addendum, if any, attached hereto is hereby incorporated herein and made an integral part hereof. 
  
 m. Reimbursement of Legal Fees. Together with Tenant’s execution and delivery of this Lease to Landlord, Tenant shall reimburse Landlord for its
reasonable legal fees and disbursements, not to exceed Ten Thousand Dollars ($10,000.00) in connection with the drafting and negotiating of this Lease and the documentation necessary to effect the termination of the lease of the Premises by the
current tenant thereof. 
  

 25 

 IN WITNESS WHEREOF, the parties have executed this Lease on the dates set forth below, effective as of the
date first above written. 
  

	Landlord:	 	 	 	Tenant:
	UTAH PARTNERS, LTD.,
a California limited partnership	 	 	 	RENOVIS, INC.,
a Delaware corportion
					
	 By:
	 	 Simeon Edgewater Properties,
a California corporation,

 General Partner
	 	 	 	 	 	 
	 	 	 	 	By:	 	 /s/    LYNNE
ZYDOWSKY        

	 	 	 	 	 	 	 Name:
	 	Lynne Zydowsky
	 	 	 	 	 	 	 	 	 	 	 Title:
	 	President & COO
					
	By:	 	 /s/    MICHAEL S.
ERB        

	 	 	 	 	 	 
	 	 	 Name:
	 	Michael S. Erb	 	 	 	 	 	 	 	 
	 	 	 Title:
	 	Sr. Vice President	 	 	 	 	 	 	 	 

  

 26

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