Document:

exv4w4

Exhibit
4.4

THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF
1933, AND HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A VIEW TO, OR IN CONNECTION WITH, THE SALE
OR DISTRIBUTION THEREOF. NO SUCH SALE OR DISTRIBUTION MAY BE EFFECTED WITHOUT AN EFFECTIVE
REGISTRATION STATEMENT RELATED THERETO OR AN OPINION OF COUNSEL IN A FORM SATISFACTORY TO THE
COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED UNDER THE SECURITIES ACT OF 1933.

 

	 	 	 
	Warrant No. _________

Date of Issuance: _________

	 	Number of Shares: _________

        (subject to adjustment)

OMEROS CORPORATION

Series E Preferred Stock Purchase Warrant

     Omeros Corporation (the “Company”), for value received, hereby certifies that ______,
or its registered assigns (the “Registered Holder”), is entitled, subject to the terms set
forth below, to purchase from the Company, at any time after the date hereof and on or before the
Expiration Date (as defined in Section 6 below), up to ______shares of Series E Preferred Stock of
the Company (“Preferred Stock”), at a purchase price of $  per share. The shares
purchasable upon exercise of this Warrant and the purchase price per share, as adjusted from time
to time pursuant to the provisions of this Warrant, are hereinafter referred to as the “Warrant
Stock” and the “Purchase Price,” respectively.

     1. Exercise.

        (a) Manner of Exercise. Subject to Section 17(a) below, this Warrant may be exercised
by the Registered Holder, in whole or in part, by surrendering this Warrant, with the purchase form
appended hereto as Exhibit A duly executed by such Registered Holder or by such Registered
Holder’s duly authorized attorney, at the principal office of the Company, or at such other office
or agency as the Company may designate, accompanied by payment in full of the Purchase Price
payable in respect of the number of shares of Warrant Stock purchased upon such exercise. The
Purchase Price may be paid by cash, check, wire transfer or by the surrender of promissory notes or
other instruments representing indebtedness of the Company to the Registered Holder.

        (b) Effective Time of Exercise. Each exercise of this Warrant shall be deemed to have
been effected immediately prior to the close of business on the day on which this Warrant shall
have been surrendered to the Company as provided in Section 1(a) above. At such time, the person
or persons in whose name or names any certificates for Warrant Stock shall be issuable upon such
exercise as provided in Section 1(d) below shall be deemed to have become the holder or holders of
record of the Warrant Stock represented by such certificates.

 

 

        (c) Net Issue Exercise.

            (i) Subject to Section 17(a) below, in lieu of exercising this Warrant in the manner provided
above in Section 1(a), the Registered Holder may elect to receive shares equal to the value of this
Warrant (or the portion thereof being canceled) by surrender of this Warrant at the principal
office of the Company together with notice of such election in which event the Company shall issue
to such Holder a number of shares of Warrant Stock computed using the following formula:

	 	 	 	 	 	 	 
	 

	 	X =
	 	Y (A–B)
 

A
	 	 

	 	 	 	 	 
	Where

	 	X =
	 	The number of shares of Warrant Stock to be issued to the Registered Holder.
	 
	 

	 	Y =
	 	The number of shares of Warrant Stock purchasable under this Warrant (at the date of such calculation).
	 
	 

	 	A =
	 	The fair market value of one share of Warrant Stock (at the date of such calculation).
	 
	 

	 	B =
	 	The Purchase Price (as adjusted to the date of such calculation).

            (ii) For purposes of this Section 1(c), the fair market value of Warrant Stock on the date of
calculation shall mean with respect to each share of Warrant Stock:

                (A) if the exercise is in connection with an initial public offering of the Company’s Common
Stock, and if the Company’s Registration Statement relating to such public offering has been
declared effective by the Securities and Exchange Commission, then the fair market value per share
shall be the product of (x) the initial “Price to Public” specified in the final prospectus with
respect to the offering and (y) the number of shares of Common Stock into which each share of
Warrant Stock is convertible at the date of calculation;

                (B) if (A) is not applicable, the fair market value of Warrant Stock shall be at the highest
price per share which the Company could obtain on the date of calculation from a willing buyer (not
a current employee or director) for shares of Warrant Stock sold by the Company, from authorized
but unissued shares, as determined in good faith by the Board of Directors, unless the Company is
at such time subject to an acquisition as described in Section 5(b) below, in which case the fair
market value of Warrant Stock shall be deemed to be the value received by the holders of such stock
pursuant to such acquisition.

        (d) Delivery to Holder. As soon as practicable after the exercise of this Warrant in
whole or in part, and in any event within ten (10) days thereafter, the Company at its expense will
cause to be issued in the name of, and delivered to, the Registered Holder, or as such Holder (upon
payment by such Holder of any applicable transfer taxes) may direct:

            (i) a certificate or certificates for the number of shares of Warrant Stock to which such
Registered Holder shall be entitled, and

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            (ii) in case such exercise is in part only, a new warrant or warrants (dated the date hereof)
of like tenor, calling in the aggregate on the face or faces thereof for the number of shares of
Warrant Stock equal (without giving effect to any adjustment therein) to the number of such shares
called for on the face of this Warrant minus the number of such shares purchased by the Registered
Holder upon such exercise as provided in Section 1(a) or 1(c) above.

     2. Adjustments.

        (a) Redemption or Conversion of Preferred Stock. If all of the Preferred Stock is
redeemed or converted into shares of Common Stock, then this Warrant shall automatically become
exercisable for that number of shares of Common Stock equal to the number of shares of Common Stock
that would have been received if this Warrant had been exercised in full and the shares of
Preferred Stock received thereupon had been simultaneously converted into shares of Common Stock
immediately prior to such event, and the Exercise Price shall be automatically adjusted to equal
the number obtained by dividing (i) the aggregate Purchase Price of the shares of Preferred Stock
for which this Warrant was exercisable immediately prior to such redemption or conversion, by (ii)
the number of shares of Common Stock for which this Warrant is exercisable immediately after such
redemption or conversion.

        (b) Stock Splits and Dividends. If outstanding shares of the Company’s Preferred
Stock shall be subdivided into a greater number of shares or a dividend in Preferred Stock shall be
paid in respect of Preferred Stock, the Purchase Price in effect immediately prior to such
subdivision or at the record date of such dividend shall simultaneously with the effectiveness of
such subdivision or immediately after the record date of such dividend be proportionately reduced.
If outstanding shares of Preferred Stock shall be combined into a smaller number of shares, the
Purchase Price in effect immediately prior to such combination shall, simultaneously with the
effectiveness of such combination, be proportionately increased. When any adjustment is required
to be made in the Purchase Price, the number of shares of Warrant Stock purchasable upon the
exercise of this Warrant shall be changed to the number determined by dividing (i) an amount equal
to the number of shares issuable upon the exercise of this Warrant immediately prior to such
adjustment, multiplied by the Purchase Price in effect immediately prior to such adjustment, by
(ii) the Purchase Price in effect immediately after such adjustment.

        (c) Reclassification, Etc. In case there occurs any reclassification or change of the
outstanding securities of the Company or of any reorganization of the Company (or any other
corporation the stock or securities of which are at the time receivable upon the exercise of this
Warrant) or any similar corporate reorganization on or after the date hereof, then and in each such
case the Registered Holder, upon the exercise hereof at any time after the consummation of such
reclassification, change, or reorganization shall be entitled to receive, in lieu of the stock or
other securities and property receivable upon the exercise hereof prior to such consummation, the
stock or other securities or property to which such Holder would have been entitled upon such
consummation if such Holder had exercised this Warrant immediately prior thereto, all subject to
further adjustment pursuant to the provisions of this Section 2.

-3-

 

        (d) Adjustment Certificate. When any adjustment is required to be made in the Warrant
Stock or the Purchase Price pursuant to this Section 2, the Company shall promptly mail to the
Registered Holder a certificate setting forth (i) a brief statement of the facts requiring such
adjustment, (ii) the Purchase Price after such adjustment and (iii) the kind and amount of stock or
other securities or property into which this Warrant shall be exercisable after such adjustment.

        (e) Acknowledgment. In order to avoid doubt, it is acknowledged that the holder of
this Warrant shall be entitled to the benefit of all adjustments in the number of shares of Common
Stock of the Company issuable upon conversion of the Preferred Stock of the Company which occur
prior to the exercise of this Warrant, including without limitation, any increase in the number of
shares of Common Stock issuable upon conversion as a result of a dilutive issuance of capital
stock.

     3. Transfers.

        (a) Unregistered Security. Each holder of this Warrant acknowledges that this
Warrant, the Warrant Stock and the Common Stock of the Company have not been registered under the
Securities Act of 1933, as amended (the “Securities Act”), and agrees not to sell, pledge,
distribute, offer for sale, transfer or otherwise dispose of this Warrant, any Warrant Stock issued
upon its exercise or any Common Stock issued upon conversion of the Warrant Stock in the absence of
(i) an effective registration statement under the Act as to this Warrant, such Warrant Stock or
such Common Stock and registration or qualification of this Warrant, such Warrant Stock or such
Common Stock under any applicable U.S. federal or state securities law then in effect, or (ii) an
opinion of counsel, satisfactory to the Company, that such registration and qualification are not
required. Each certificate or other instrument for Warrant Stock issued upon the exercise of this
Warrant shall bear a legend substantially to the foregoing effect. Notwithstanding the foregoing,
this Section 3(a) shall not be applicable to distributions of this Warrant by ___
(“___”) to its Permitted Transferees (as defined below) in accordance with the terms
and conditions of Section 17(b) below.

        (b) Transferability. Subject to the provisions of Sections 3(a), 3(d) and 17(b)
hereof, this Warrant and all rights hereunder are transferable, in whole or in part, upon surrender
of the Warrant with a properly executed assignment (in the form of Exhibit B hereto) at the
principal office of the Company.

        (c) Warrant Register. The Company will maintain a register containing the names and
addresses of the Registered Holders of this Warrant. Until any transfer of this Warrant is made in
the warrant register, the Company may treat the Registered Holder of this Warrant as the absolute
owner hereof for all purposes; provided, however, that if this Warrant is properly
assigned in blank, the Company may (but shall not be required to) treat the bearer hereof as the
absolute owner hereof for all purposes, notwithstanding any notice to the contrary. Any Registered
Holder may change such Registered Holder’s address as shown on the warrant register by written
notice to the Company requesting such change.

        (d) “Market Stand-Off” Agreement. Each Registered Holder hereby agrees that, during
the period of duration (up to, but not exceeding, 180 days) specified by the Company

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        and an
underwriter of Common Stock or other securities of the Company, following the effective date of a
registration statement of the Company filed under the Securities Act, it shall not, to the extent
requested by the Company and such underwriter, directly or indirectly sell, offer to sell, contract
to sell (including, without limitation, any short sale), grant any option to purchase or otherwise
transfer or dispose of (other than to donees who agree to be similarly bound) any securities of the
Company held by it at any time during such period except Common Stock included in such
registration; provided, however, that:

            (i) such agreement shall be applicable only to the first such registration statement of the
Company which covers Common Stock (or other securities) to be sold on its behalf to the public in
an underwritten offering; and

            (ii) all officers and directors of the Company, all one-percent securityholders, and all other
persons with registration rights (whether or not pursuant to this Agreement) enter into similar
agreements.

     In order to enforce the foregoing covenant, the Company may impose stop-transfer instructions
with respect to the Registrable Securities of each Registered Holder (and the shares or securities
of every other person subject to the foregoing restriction) until the end of such period, and each
Registered Holder agrees that, if so requested, such Registered Holder will execute an agreement in
the form provided by the underwriter containing terms which are essentially consistent with the
provisions of this Section 3(d).

     Notwithstanding the foregoing, the obligations described in this Section 3(d) shall not apply
to a registration relating solely to employee benefit plans on Form S-1 or Form S-8 or similar
forms which may be promulgated in the future, or a registration relating solely to an SEC Rule 145
transaction on Form S-4 or similar forms which may be promulgated in the future.

        (e) Rights Agreement. Each Registered Holder agrees that the Warrant Stock shall be
subject to all of the covenants, including stock transfer restrictions set forth in Section 3, of
the Amended and Restated Investors’ Rights Agreement dated October 15, 2004 by and among the
Company and the investors named therein, as such may be amended from time to time (the “Rights
Agreement”), including without limitation any transfer restrictions set forth in any amendments
to or restatements of Section 3 of the Rights Agreement; provided, however, that the Warrant Stock
shall not be deemed “Registrable Securities” pursuant to the terms of the Rights Agreement unless
and until such time as the Registered Holder is an “Investor” pursuant to the terms of the Rights
Agreement. The Company agrees to provide a copy of the Rights Agreement to each Registered Holder
upon its request, and by acceptance of this Warrant, each Registered Holder acknowledges that it
has received a copy of the Rights Agreement from the Company or that it has voluntarily not
requested a copy of the Rights Agreement from the Company.

     4. Representations and Warranties of the Registered Holders. Each Registered Holder
hereby represents and warrants to the Company that:

        4.1 Purchase Entirely for Own Account. This Warrant is issued to the Registered
Holder in reliance upon the Registered Holder’s representation to the Company,

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        which by the
Registered Holder’s acceptance of this Agreement, the Registered Holder hereby confirms, that any
Warrant Stock to be acquired by the Registered Holder upon exercise of this Warrant will be
acquired for investment for the Registered Holder’s own account, not as a nominee or agent, and not
with a view to the resale or distribution of any part thereof, and that the Registered Holder has
no present intention of selling, granting any participation in, or otherwise distributing the same.
By accepting this Warrant, the Registered Holder further represents that the Registered Holder
does not presently have any contract, undertaking, agreement or arrangement with any person to
sell, transfer or grant participations to such person or to any third person, with respect to any
of the Warrant Stock. The Registered Holder has not been formed for the specific purpose of
acquiring the Warrant Stock.

        4.2 Disclosure of Information. The Registered Holder has had an opportunity to
discuss the Company’s business, management, financial affairs and the terms and conditions of the
Warrant with the Company’s management and has had an opportunity to review the Company’s
facilities. The Registered Holder understands that such discussions, as well as the Company’s
Business Plan and any other written information delivered by the Company to the Registered Holder,
were intended to describe the aspects of the Company’s business which it believes to be material.

        4.3 Restricted Securities. The Registered Holder understands that the Warrant Stock
has not been, and will not be, registered under the Securities Act, by reason of a specific
exemption from the registration provisions of the Securities Act which depends upon, among other
things, the bona fide nature of the investment intent and the accuracy of the Registered Holder’s
representations as expressed herein. The Registered Holder understands that the shares of Warrant
Stock are “restricted securities” under applicable U.S. federal and state securities laws and that,
pursuant to these laws, the Registered Holder must hold the Warrant Stock indefinitely unless such
shares are registered with the Securities and Exchange Commission and qualified by state
authorities, or an exemption from such registration and qualification requirements is available.
The Registered Holder acknowledges that the Company has no obligation to the Registered Holder to
register or qualify the Warrant Stock for resale. The Registered Holder further acknowledges that
if an exemption from registration or qualification is available, it may be conditioned on various
requirements including, but not limited to, the time and manner of sale, the holding period for the
Warrant Stock, and on requirements relating to the Company which are outside of the Registered
Holder’s control, and which the Company is under no obligation and may not be able to satisfy.

        4.4 No Public Market. The Registered Holder understands that no public market now
exists for any of the securities issued by the Company, and that the Company has made no assurances
that a public market will ever exist for the Warrant Stock.

        4.5 Legends. The Registered Holder understands that the Warrant Stock and any
securities issued in respect of or exchange for the Warrant Stock, may bear one or all of the
following legends:

            (a) “THE SHARES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES
ACT OF 1933, AND HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A VIEW TO, OR IN

-6-

 

            CONNECTION WITH,
THE SALE OR DISTRIBUTION THEREOF. NO SUCH SALE OR DISTRIBUTION MAY BE EFFECTED WITHOUT AN
EFFECTIVE REGISTRATION STATEMENT RELATED THERETO OR AN OPINION OF COUNSEL IN A FORM SATISFACTORY TO
THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED UNDER THE SECURITIES ACT OF 1933.”

            (b) Any legends set forth in the Rights Agreements and any other agreements to which the
Company and the Registered Holder are party.

            (c) Any legend required by the Blue Sky laws of any state to the extent such laws are
applicable to the shares represented by the certificate so legended.

        4.6 Accredited Investor. The Registered Holder is an accredited investor as defined
in Rule 501(a) of Regulation D promulgated under the Securities Act.

     5. No Impairment. The Company will not, by amendment of its charter or through
reorganization, consolidation, merger, dissolution, sale of assets or any other voluntary action,
avoid or seek to avoid the observance or performance of any of the terms of this Warrant, but will
(subject to Section 14 below) at all times in good faith assist in the carrying out of all such
terms and in the taking of all such action as may be necessary or appropriate in order to protect
the rights of the holder of this Warrant against impairment.

     6. Termination. This Warrant (and the right to purchase securities upon exercise
hereof) shall terminate upon the earliest to occur of the following (the “Expiration
Date”): (a) March 29, 2012 (the “Termination Date”), (b) the sale, conveyance,
disposal, or encumbrance of all or substantially all of the Company’s property or business or the
Company’s merger into or consolidation with any other corporation (other than a wholly-owned
subsidiary corporation) or any other transaction or series of related transactions in which more
than fifty percent (50%) of the voting power of the Company is disposed of (a “Sale of the
Company”), provided that this Section 6(b) shall not apply to a merger effected
exclusively for the purpose of changing the domicile of the Company, or (c) the closing of a firm
commitment underwritten public offering pursuant to a registration statement on Form S-1 under the
Securities Act, which results in aggregate cash proceeds to the Company of at least $10,000,000
(net of underwriting discounts and commissions) (a “Qualified IPO”).

     7. Notices of Certain Transactions. In case:

        (a) the Company shall take a record of the holders of its Preferred Stock (or other stock or
securities at the time deliverable upon the exercise of this Warrant) for the purpose of entitling
or enabling them to receive any dividend or other distribution, or to receive any right to
subscribe for or purchase any shares of stock of any class or any other securities, or to receive
any other right, to subscribe for or purchase any shares of stock of any class or any other
securities, or to receive any other right, or

        (b) of any capital reorganization of the Company, any reclassification of the capital stock of
the Company, any consolidation or merger of the Company, any consolidation or merger of the Company
with or into another corporation (other than a consolidation or merger

-7-

 

        in which the Company is the
surviving entity), or any transfer of all or substantially all of the assets of the Company, or

        (c) of the voluntary or involuntary dissolution, liquidation or winding-up of the Company, or

        (d) of any redemption of the Preferred Stock or mandatory conversion of the Preferred Stock
into Common Stock of the Company,

     then, and in each such case, the Company will mail or cause to be mailed to the Registered Holder
of this Warrant a notice specifying, as the case may be, (i) the date on which a record is to be
taken for the purpose of such dividend, distribution or right, and stating the amount and character
of such dividend, distribution or right, or (ii) the effective date on which such reorganization,
reclassification, consolidation, merger, transfer, dissolution, liquidation, winding-up, redemption
or conversion is to take place, and the time, if any is to be fixed, as of which the holders of
record of Preferred Stock (or such other stock or securities at the time deliverable upon such
reorganization, reclassification, consolidation, merger, transfer, dissolution, liquidation,
winding-up, redemption or conversion) are to be determined. Such notice shall be mailed at least
ten (10) days prior to the record date or effective date for the event specified in such notice.

     8. Reservation of Stock. The Company will at all times reserve and keep available,
solely for the issuance and delivery upon the exercise of this Warrant, such shares of Warrant
Stock and other stock, securities and property, as from time to time shall be issuable upon the
exercise of this Warrant.

     9. Exchange of Warrants. Upon the surrender by the Registered Holder of any Warrant
or Warrants, properly endorsed, to the Company at the principal office of the Company, the Company
will, subject to the provisions of Sections 3 and 17(b) hereof, issue and deliver to or upon the
order of such Holder, at the Company’s expense, a new Warrant or Warrants of like tenor, in the
name of such Registered Holder or as such Registered Holder (upon payment by such Registered Holder
of any applicable transfer taxes) may direct, calling in the aggregate on the face or faces thereof
for the number of shares of Preferred Stock called for on the face or faces of the Warrant or
Warrants so surrendered.

     10. Replacement of Warrants. Upon receipt of evidence reasonably satisfactory to the
Company of the loss, theft, destruction or mutilation of this Warrant and (in the case of loss,
theft or destruction) upon delivery of an indemnity agreement (with surety if reasonably required)
in an amount reasonably satisfactory to the Company, or (in the case of mutilation) upon surrender
and cancellation of this Warrant, the Company will issue, in lieu thereof, a new Warrant of like
tenor.

     11. Mailing of Notices. Any notice required or permitted pursuant to this Warrant
shall be in writing and shall be deemed sufficient upon receipt, when delivered personally or sent
by courier, overnight delivery service or confirmed facsimile, or forty-eight (48) hours after
being deposited in the regular mail, as certified or registered mail (airmail if sent
internationally), with postage prepaid, addressed (a) if to the Registered Holder, to the address
of

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     the Registered Holder most recently furnished in writing to the Company and (b) if to the
Company, to the address set forth below or subsequently modified by written notice to the
Registered Holder.

     12. No Rights as Shareholder. Until the exercise of this Warrant, the Registered
Holder of this Warrant shall not have or exercise any rights by virtue hereof as a shareholder of
the Company.

     13. No Fractional Shares. No fractional shares of Preferred Stock will be issued in
connection with any exercise hereunder. In lieu of any fractional shares which would otherwise be
issuable, the Company shall pay cash equal to the product of such fraction multiplied by the fair
market value of one share of Preferred Stock on the date of exercise, as determined in good faith
by the Company’s Board of Directors.

     14. Amendment or Waiver. Any term of this Warrant may be amended or waived only by an
instrument in writing signed by the party against which enforcement of the amendment or waiver is
sought.

     15. Headings. The headings in this Warrant are for purposes of reference only and
shall not limit or otherwise affect the meaning of any provision of this Warrant.

     16. Governing Law. This Warrant shall be governed, construed and interpreted in
accordance with the laws of the State of Washington, without giving effect to principles of
conflicts of law.

     17. Distribution. In exchange for granting ___the right to distribute this
Warrant in accordance with Section 17(b) below, ___, its Permitted Transferees (if any) and the
Company agree as follows:

        (a) This Warrant and any warrants issued directly or indirectly by the Company as a result of
the sale, pledge, distribution, offer for sale, transfer or other disposition or substitution or
replacement of this Warrant (“Subsequent Warrants”) may only be exercised pursuant to
Section 1 above or otherwise upon the earliest to occur of the following: (i) the closing of a
Qualified IPO, (ii) the closing of a Sale of the Company, (iii) at any time within thirty (30) days
prior to the Termination Date, (iv) immediately prior to the closing of a merger or consolidation
of the Company in which the shareholders of the Company receive in exchange for their securities of
the Company securities that are registered under the Securities Exchange Act of 1934 (the
“Exchange Act”) and (v) at any time after the Company has a class of its securities
registered under the Exchange Act, other than as a result of the filing by the Company of a
registration statement on Form 8-A in connection with a Qualified IPO; provided,
however, that if the registration statement on Form 8-A is filed in connection with a
Qualified IPO and the Company withdraws the related registration statement filed on Form S-1 but
does not within two (2) business days thereafter file a form with the SEC indicating its intention to terminate
the registration of its securities under the Exchange Act, then the Warrants shall be exercisable
at any time three (3) business days after the Company withdraws the registration statement on Form
S-1.

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        (b) ___may distribute this Warrant without compliance with Section 3(a) above to any of its
individual members and employees who have provided to the Company a completed accredited investor
questionnaire in the form appended hereto as Exhibit C pursuant to which such person has
warranted to the Company that he or she is an accredited investor as defined in Rule 501(a)
promulgated under the Securities Act (a “Permitted Transferee”). This Section 17(b) shall
only be applicable to distributions of this Warrant by ___to Permitted Transferees and not to
any other sale, pledge, distribution, offer for sale, transfer or other disposition of this Warrant
or a Subsequent Warrant by ___or any Permitted Transferee.

	 	 	 
	 

	 	OMEROS CORPORATION
	 
	 	 
	 
	 	 
	 

	 	By: _________________________________
	 

	 	Name: _______________________________
	 

	 	Its: _________________________________

	 	 	 	 	 
	 

	 	Address:
	 	1420 Fifth Avenue, Suite 2600

Seattle, Washington 98101
	 
	 

	 	Fax Number:
	 	(206) 264-7856

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EXHIBIT A

PURCHASE FORM

	 	 	 
	To:    Omeros Corporation
	 	Dated:

     The undersigned, pursuant to the provisions set forth in the attached Warrant
No. WE-               ,
hereby irrevocably elects to purchase                     shares of the Series E Preferred Stock covered
by such Warrant and herewith makes payment of $                    , representing the full purchase price for
such shares at the price per share provided for in such Warrant.

     The undersigned acknowledges that it has reviewed the representations and warranties contained
in Section 4 of the Warrant and by its signature below hereby makes such representations and
warranties to the Company. Defined terms contained in such representations and warranties shall
have the meanings assigned to them in the Purchase Agreement, provided that the term
“Registered Holder” shall refer to the undersigned and the term “Securities” shall refer to the
Warrant Stock and the Common Stock of the Company issuable upon conversion of the Warrant Stock.

     The undersigned acknowledges that it has reviewed the market standoff provisions set forth in
Section 3(d) of the Warrant and agrees to be bound by such provisions.

     The undersigned further acknowledges that the Securities are subject to the stock transfer
restrictions set forth in Section 3 of the Amended and Restated Investors’ Rights Agreement dated
October 15, 2004 by and among the Company and the investors named therein, as such may be amended
from time to time (the “Rights Agreement”), including without limitation any transfer
restrictions set forth in any amendments to or restatements of Section 3 of the Rights Agreement.
The undersigned further acknowledges that it has received a copy of the Rights Agreement from the
Company (which the Company will provide upon request) or that it has voluntarily not requested a
copy of the Rights Agreement from the Company.

	 	 	 	 	 	 	 
	 

	 	Signature:	 	 	 	 
	 

	 	 	 	 

	 	 
	 

	 	Name (print):	 	 	 	 
	 

	 	 	 	 	 	 
	 
	 	 	 	 	 	 
	 

	 	Title (if applic.)	 	 	 	 
	 

	 	 	 	 	 	 
	 
	 	 	 	 	 	 
	 

	 	Company (if applic.):	 	 	 	 
	 

	 	 	 	 	 	 

 

 

EXHIBIT B

ASSIGNMENT FORM

     FOR VALUE RECEIVED,                 hereby sells, assigns and transfers all of the
rights of the undersigned under the attached Warrant with respect to the number of shares of Series
E Preferred Stock covered thereby set forth below, unto:

	 	 	 	 	 	 	 
	Name of Assignee	 	 	Address/Fax Number	 	 	No. of Shares

	 	 	 	 	 	 	 	 
	Dated:

	 	 	Signature:	 	 	 	 
	 
	 

	 	 	 	 

	 	 
	 

	 	 	 	 	 	 	 
	 

	 	 	 	 	 

	 	 
	 

	 	 	Witness:	 	 	 	 
	 

	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 

3exv4w5

Exhibit
4.5

THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF
1933, AND HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A VIEW TO, OR IN CONNECTION WITH, THE SALE
OR DISTRIBUTION THEREOF. NO SUCH SALE OR DISTRIBUTION MAY BE EFFECTED WITHOUT AN EFFECTIVE
REGISTRATION STATEMENT RELATED THERETO OR AN OPINION OF COUNSEL IN A FORM SATISFACTORY TO THE
COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED UNDER THE SECURITIES ACT OF 1933.

 

	 	 	 
	Warrant No. _________

Date of Issuance: _________

	 	Number of Shares: _________

        (subject to adjustment)

OMEROS CORPORATION

Series E Preferred Stock Purchase Warrant

     Omeros Corporation (the “Company”), for value received, hereby certifies that ___,
or its registered assigns (the “Registered Holder”), is entitled, subject to the terms set
forth below, to purchase from the Company, at any time after the date hereof and on or before the
Expiration Date (as defined in Section 6 below), up to ___shares of Series E Preferred Stock of
the Company (“Preferred Stock”), at a purchase price of $  per share. The shares
purchasable upon exercise of this Warrant and the purchase price per share, as adjusted from time
to time pursuant to the provisions of this Warrant, are hereinafter referred to as the “Warrant
Stock” and the “Purchase Price,” respectively.

     1. Exercise.

          (a) Manner of Exercise. This Warrant may be exercised by the Registered Holder, in
whole or in part, by surrendering this Warrant, with the purchase form appended hereto as
Exhibit A duly executed by such Registered Holder or by such Registered Holder’s duly
authorized attorney, at the principal office of the Company, or at such other office or agency as
the Company may designate, accompanied by payment in full of the Purchase Price payable in respect
of the number of shares of Warrant Stock purchased upon such exercise. The Purchase Price may be
paid by cash, check, wire transfer or by the surrender of promissory notes or other instruments
representing indebtedness of the Company to the Registered Holder.

          (b) Effective Time of Exercise. Each exercise of this Warrant shall be deemed to have
been effected immediately prior to the close of business on the day on which this Warrant shall
have been surrendered to the Company as provided in Section 1(a) above. At such time, the person
or persons in whose name or names any certificates for Warrant Stock shall be issuable upon such
exercise as provided in Section 1(d) below shall be deemed to have become the holder or holders of
record of the Warrant Stock represented by such certificates.

          (c) Net Issue Exercise.

               (i) In lieu of exercising this Warrant in the manner provided above in Section 1(a), the
Registered Holder may elect to receive shares equal to the value of this Warrant

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(or the portion thereof being canceled) by surrender of this Warrant at the principal office of the Company
together with notice of such election in which event the Company shall issue to such Holder a
number of shares of Warrant Stock computed using the following formula:

	 	 	 	 	 	 	 
	 

	 	X =
	 	Y (A–B)
 

A
	 	 

	 	 	 
	Where

	 	X = The number of shares of Warrant Stock to be issued to the Registered Holder.
	 

	 	Y = The number of shares of Warrant Stock purchasable under this Warrant (at the date of such calculation).
	 

	 	A = The fair market value of one share of Warrant Stock (at the date of such calculation).
	 

	 	B = The Purchase Price (as adjusted to the date of such calculation).

               (ii) For purposes of this Section 1(c), the fair market value of Warrant Stock on the date of
calculation shall mean with respect to each share of Warrant Stock:

                    (A) if the exercise is in connection with an initial public offering of the Company’s Common
Stock, and if the Company’s Registration Statement relating to such public offering has been
declared effective by the Securities and Exchange Commission, then the fair market value per share
shall be the product of (x) the initial “Price to Public” specified in the final prospectus with
respect to the offering and (y) the number of shares of Common Stock into which each share of
Warrant Stock is convertible at the date of calculation;

                    (B) if (A) is not applicable, the fair market value of Warrant Stock shall be at the highest
price per share which the Company could obtain on the date of calculation from a willing buyer (not
a current employee or director) for shares of Warrant Stock sold by the Company, from authorized
but unissued shares, as determined in good faith by the Board of Directors, unless the Company is
at such time subject to an acquisition as described in Section 5(b) below, in which case the fair
market value of Warrant Stock shall be deemed to be the value received by the holders of such stock
pursuant to such acquisition.

          (d) Delivery to Holder. As soon as practicable after the exercise of this Warrant in
whole or in part, and in any event within ten (10) days thereafter, the Company at its expense will
cause to be issued in the name of, and delivered to, the Registered Holder, or as such Holder (upon
payment by such Holder of any applicable transfer taxes) may direct:

               (i) a certificate or certificates for the number of shares of Warrant Stock to which such
Registered Holder shall be entitled, and

               (ii) in case such exercise is in part only, a new warrant or warrants (dated the date hereof)
of like tenor, calling in the aggregate on the face or faces thereof for the number of shares of
Warrant Stock equal (without giving effect to any adjustment therein) to the number of such shares called for on the face of this Warrant minus the number of such shares

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purchased by the Registered
Holder upon such exercise as provided in Section 1(a) or 1(c) above.

     2. Adjustments.

          (a) Redemption or Conversion of Preferred Stock. If all of the Preferred Stock is
redeemed or converted into shares of Common Stock, then this Warrant shall automatically become
exercisable for that number of shares of Common Stock equal to the number of shares of Common Stock
that would have been received if this Warrant had been exercised in full and the shares of
Preferred Stock received thereupon had been simultaneously converted into shares of Common Stock
immediately prior to such event, and the Exercise Price shall be automatically adjusted to equal
the number obtained by dividing (i) the aggregate Purchase Price of the shares of Preferred Stock
for which this Warrant was exercisable immediately prior to such redemption or conversion, by (ii)
the number of shares of Common Stock for which this Warrant is exercisable immediately after such
redemption or conversion.

          (b) Stock Splits and Dividends. If outstanding shares of the Company’s Preferred
Stock shall be subdivided into a greater number of shares or a dividend in Preferred Stock shall be
paid in respect of Preferred Stock, the Purchase Price in effect immediately prior to such
subdivision or at the record date of such dividend shall simultaneously with the effectiveness of
such subdivision or immediately after the record date of such dividend be proportionately reduced.
If outstanding shares of Preferred Stock shall be combined into a smaller number of shares, the
Purchase Price in effect immediately prior to such combination shall, simultaneously with the
effectiveness of such combination, be proportionately increased. When any adjustment is required
to be made in the Purchase Price, the number of shares of Warrant Stock purchasable upon the
exercise of this Warrant shall be changed to the number determined by dividing (i) an amount equal
to the number of shares issuable upon the exercise of this Warrant immediately prior to such
adjustment, multiplied by the Purchase Price in effect immediately prior to such adjustment, by
(ii) the Purchase Price in effect immediately after such adjustment.

          (c) Reclassification, Etc. In case there occurs any reclassification or change of the
outstanding securities of the Company or of any reorganization of the Company (or any other
corporation the stock or securities of which are at the time receivable upon the exercise of this
Warrant) or any similar corporate reorganization on or after the date hereof, then and in each such
case the Registered Holder, upon the exercise hereof at any time after the consummation of such
reclassification, change, or reorganization shall be entitled to receive, in lieu of the stock or
other securities and property receivable upon the exercise hereof prior to such consummation, the
stock or other securities or property to which such Holder would have been entitled upon such
consummation if such Holder had exercised this Warrant immediately prior thereto, all subject to
further adjustment pursuant to the provisions of this Section 2.

          (d) Adjustment Certificate. When any adjustment is required to be made in the Warrant
Stock or the Purchase Price pursuant to this Section 2, the Company shall promptly mail to the
Registered Holder a certificate setting forth (i) a brief statement of the facts requiring such
adjustment, (ii) the Purchase Price after such adjustment and (iii) the kind and amount of

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stock or other securities or property into which this Warrant shall be exercisable after such adjustment.

          (e) Acknowledgment. In order to avoid doubt, it is acknowledged that the holder of
this Warrant shall be entitled to the benefit of all adjustments in the number of shares of Common
Stock of the Company issuable upon conversion of the Preferred Stock of the Company which occur
prior to the exercise of this Warrant, including without limitation, any increase in the number of
shares of Common Stock issuable upon conversion as a result of a dilutive issuance of capital
stock.

     3. Transfers.

          (a) Unregistered Security. Each holder of this Warrant acknowledges that this
Warrant, the Warrant Stock and the Common Stock of the Company have not been registered under the
Securities Act of 1933, as amended (the “Securities Act”), and agrees not to sell, pledge,
distribute, offer for sale, transfer or otherwise dispose of this Warrant, any Warrant Stock issued
upon its exercise or any Common Stock issued upon conversion of the Warrant Stock in the absence of
(i) an effective registration statement under the Act as to this Warrant, such Warrant Stock or
such Common Stock and registration or qualification of this Warrant, such Warrant Stock or such
Common Stock under any applicable U.S. federal or state securities law then in effect, or (ii) an
opinion of counsel, satisfactory to the Company, that such registration and qualification are not
required. Each certificate or other instrument for Warrant Stock issued upon the exercise of this
Warrant shall bear a legend substantially to the foregoing effect.

          (b) Transferability. Subject to the provisions of Sections 3(a) and 3(d) hereof, this
Warrant and all rights hereunder are transferable, in whole or in part, upon surrender of the
Warrant with a properly executed assignment (in the form of Exhibit B hereto) at the
principal office of the Company.

          (c) Warrant Register. The Company will maintain a register containing the names and
addresses of the Registered Holders of this Warrant. Until any transfer of this Warrant is made in
the warrant register, the Company may treat the Registered Holder of this Warrant as the absolute
owner hereof for all purposes; provided, however, that if this Warrant is properly
assigned in blank, the Company may (but shall not be required to) treat the bearer hereof as the
absolute owner hereof for all purposes, notwithstanding any notice to the contrary. Any Registered
Holder may change such Registered Holder’s address as shown on the warrant register by written
notice to the Company requesting such change.

          (d) “Market Stand-Off” Agreement. Each Registered Holder hereby agrees that, during
the period of duration (up to, but not exceeding, 180 days) specified by the Company and an
underwriter of Common Stock or other securities of the Company, following the effective
date of a registration statement of the Company filed under the Securities Act, it shall not,
to the extent requested by the Company and such underwriter, directly or indirectly sell, offer to
sell, contract to sell (including, without limitation, any short sale), grant any option to
purchase or otherwise transfer or dispose of (other than to donees who agree to be similarly bound) any

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securities of the Company held by it at any time during such period except Common Stock
included in such registration; provided, however, that:

               (i) such agreement shall be applicable only to the first such registration statement of the
Company which covers Common Stock (or other securities) to be sold on its behalf to the public in
an underwritten offering; and

               (ii) all officers and directors of the Company, all one-percent securityholders, and all other
persons with registration rights (whether or not pursuant to this Agreement) enter into similar
agreements.

     In order to enforce the foregoing covenant, the Company may impose stop-transfer instructions
with respect to the Registrable Securities of each Registered Holder (and the shares or securities
of every other person subject to the foregoing restriction) until the end of such period, and each
Registered Holder agrees that, if so requested, such Registered Holder will execute an agreement in
the form provided by the underwriter containing terms which are essentially consistent with the
provisions of this Section 3(d).

     Notwithstanding the foregoing, the obligations described in this Section 3(d) shall not apply
to a registration relating solely to employee benefit plans on Form S-1 or Form S-8 or similar
forms which may be promulgated in the future, or a registration relating solely to an SEC Rule 145
transaction on Form S-4 or similar forms which may be promulgated in the future.

               (e) Rights Agreement. Each Registered Holder agrees that the Warrant Stock shall be
subject to all of the covenants, including stock transfer restrictions set forth in Section 3, of
the Amended and Restated Investors’ Rights Agreement dated October 15, 2004 by and among the
Company and the investors named therein, as such may be amended from time to time (the “Rights
Agreement”), including without limitation any transfer restrictions set forth in any amendments
to or restatements of Section 3 of the Rights Agreement; provided, however, that the Warrant Stock
shall not be deemed “Registrable Securities” pursuant to the terms of the Rights Agreement unless
and until such time as the Registered Holder is an “Investor” pursuant to the terms of the Rights
Agreement. The Company agrees to provide a copy of the Rights Agreement to each Registered Holder
upon its request, and by acceptance of this Warrant, each Registered Holder acknowledges that it
has received a copy of the Rights Agreement from the Company or that it has voluntarily not
requested a copy of the Rights Agreement from the Company.

     4. Representations and Warranties of the Registered Holders. Each Registered Holder
hereby represents and warrants to the Company that:

          4.1 Purchase Entirely for Own Account. This Warrant is issued to the Registered
Holder in reliance upon the Registered Holder’s representation to the Company,
which by the Registered Holder’s acceptance of this Agreement, the Registered Holder hereby
confirms, that any Warrant Stock to be acquired by the Registered Holder upon exercise of this
Warrant will be acquired for investment for the Registered Holder’s own account, not as a nominee
or agent, and not with a view to the resale or distribution of any part thereof, and that the
Registered Holder has no present intention of selling, granting any participation in, or

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otherwise distributing the same. By accepting this Warrant, the Registered Holder further represents that
the Registered Holder does not presently have any contract, undertaking, agreement or arrangement
with any person to sell, transfer or grant participations to such person or to any third person,
with respect to any of the Warrant Stock. The Registered Holder has not been formed for the
specific purpose of acquiring the Warrant Stock.

          4.2 Disclosure of Information. The Registered Holder has had an opportunity to
discuss the Company’s business, management, financial affairs and the terms and conditions of the
Warrant with the Company’s management and has had an opportunity to review the Company’s
facilities. The Registered Holder understands that such discussions, as well as the Company’s
Business Plan and any other written information delivered by the Company to the Registered Holder,
were intended to describe the aspects of the Company’s business which it believes to be material.

          4.3 Restricted Securities. The Registered Holder understands that the Warrant Stock
has not been, and will not be, registered under the Securities Act, by reason of a specific
exemption from the registration provisions of the Securities Act which depends upon, among other
things, the bona fide nature of the investment intent and the accuracy of the Registered Holder’s
representations as expressed herein. The Registered Holder understands that the shares of Warrant
Stock are “restricted securities” under applicable U.S. federal and state securities laws and that,
pursuant to these laws, the Registered Holder must hold the Warrant Stock indefinitely unless such
shares are registered with the Securities and Exchange Commission and qualified by state
authorities, or an exemption from such registration and qualification requirements is available.
The Registered Holder acknowledges that the Company has no obligation to the Registered Holder to
register or qualify the Warrant Stock for resale. The Registered Holder further acknowledges that
if an exemption from registration or qualification is available, it may be conditioned on various
requirements including, but not limited to, the time and manner of sale, the holding period for the
Warrant Stock, and on requirements relating to the Company which are outside of the Registered
Holder’s control, and which the Company is under no obligation and may not be able to satisfy.

          4.4 No Public Market. The Registered Holder understands that no public market now
exists for any of the securities issued by the Company, and that the Company has made no assurances
that a public market will ever exist for the Warrant Stock.

          4.5 Legends. The Registered Holder understands that the Warrant Stock and any
securities issued in respect of or exchange for the Warrant Stock, may bear one or all of the
following legends:

               (a) “THE SHARES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES
ACT OF 1933, AND HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A VIEW TO, OR IN CONNECTION WITH, THE SALE OR
DISTRIBUTION THEREOF. NO SUCH SALE OR DISTRIBUTION MAY BE EFFECTED WITHOUT AN EFFECTIVE
REGISTRATION STATEMENT RELATED THERETO OR AN OPINION OF COUNSEL IN A FORM SATISFACTORY TO THE
COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED UNDER THE SECURITIES ACT OF 1933.”

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               (b) Any legends set forth in the Rights Agreements and any other agreements to which the
Company and the Registered Holder are party.

               (c) Any legend required by the Blue Sky laws of any state to the extent such laws are
applicable to the shares represented by the certificate so legended.

          4.6 Accredited Investor. The Registered Holder is an accredited investor as defined
in Rule 501(a) of Regulation D promulgated under the Securities Act.

     5. No Impairment. The Company will not, by amendment of its charter or through
reorganization, consolidation, merger, dissolution, sale of assets or any other voluntary action,
avoid or seek to avoid the observance or performance of any of the terms of this Warrant, but will
(subject to Section 14 below) at all times in good faith assist in the carrying out of all such
terms and in the taking of all such action as may be necessary or appropriate in order to protect
the rights of the holder of this Warrant against impairment.

     6. Termination. This Warrant (and the right to purchase securities upon exercise
hereof) shall terminate upon the earliest to occur of the following (the “Expiration
Date”): (a) March 29, 2012, (b) the sale, conveyance, disposal, or encumbrance of all or
substantially all of the Company’s property or business or the Company’s merger into or
consolidation with any other corporation (other than a wholly-owned subsidiary corporation) or any
other transaction or series of related transactions in which more than fifty percent (50%) of the
voting power of the Company is disposed of, provided that this Section 6(b) shall not apply
to a merger effected exclusively for the purpose of changing the domicile of the Company, or (c)
the closing of a firm commitment underwritten public offering pursuant to a registration statement
on Form S-1 under the Securities Act, which results in aggregate cash proceeds to the Company of at
least $10,000,000 (net of underwriting discounts and commissions).

     7. Notices of Certain Transactions. In case:

     (a) the Company shall take a record of the holders of its Preferred Stock (or other stock or
securities at the time deliverable upon the exercise of this Warrant) for the purpose of entitling
or enabling them to receive any dividend or other distribution, or to receive any right to
subscribe for or purchase any shares of stock of any class or any other securities, or to receive
any other right, to subscribe for or purchase any shares of stock of any class or any other
securities, or to receive any other right, or

     (b) of any capital reorganization of the Company, any reclassification of the capital stock of
the Company, any consolidation or merger of the Company, any consolidation or
merger of the Company with or into another corporation (other than a consolidation or merger
in which the Company is the surviving entity), or any transfer of all or substantially all of the
assets of the Company, or

     (c) of the voluntary or involuntary dissolution, liquidation or winding-up of the Company, or

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          (d) of any redemption of the Preferred Stock or mandatory conversion of the Preferred Stock
into Common Stock of the Company,

then, and in each such case, the Company will mail or cause to be mailed to the Registered Holder
of this Warrant a notice specifying, as the case may be, (i) the date on which a record is to be
taken for the purpose of such dividend, distribution or right, and stating the amount and character
of such dividend, distribution or right, or (ii) the effective date on which such reorganization,
reclassification, consolidation, merger, transfer, dissolution, liquidation, winding-up, redemption
or conversion is to take place, and the time, if any is to be fixed, as of which the holders of
record of Preferred Stock (or such other stock or securities at the time deliverable upon such
reorganization, reclassification, consolidation, merger, transfer, dissolution, liquidation,
winding-up, redemption or conversion) are to be determined. Such notice shall be mailed at least
ten (10) days prior to the record date or effective date for the event specified in such notice.

     8. Reservation of Stock. The Company will at all times reserve and keep available,
solely for the issuance and delivery upon the exercise of this Warrant, such shares of Warrant
Stock and other stock, securities and property, as from time to time shall be issuable upon the
exercise of this Warrant.

     9. Exchange of Warrants. Upon the surrender by the Registered Holder of any Warrant
or Warrants, properly endorsed, to the Company at the principal office of the Company, the Company
will, subject to the provisions of Section 3 hereof, issue and deliver to or upon the order of such
Holder, at the Company’s expense, a new Warrant or Warrants of like tenor, in the name of such
Registered Holder or as such Registered Holder (upon payment by such Registered Holder of any
applicable transfer taxes) may direct, calling in the aggregate on the face or faces thereof for
the number of shares of Preferred Stock called for on the face or faces of the Warrant or Warrants
so surrendered.

     10. Replacement of Warrants. Upon receipt of evidence reasonably satisfactory to the
Company of the loss, theft, destruction or mutilation of this Warrant and (in the case of loss,
theft or destruction) upon delivery of an indemnity agreement (with surety if reasonably required)
in an amount reasonably satisfactory to the Company, or (in the case of mutilation) upon surrender
and cancellation of this Warrant, the Company will issue, in lieu thereof, a new Warrant of like
tenor.

     11. Mailing of Notices. Any notice required or permitted pursuant to this Warrant
shall be in writing and shall be deemed sufficient upon receipt, when delivered personally or sent
by courier, overnight delivery service or confirmed facsimile, or forty-eight (48) hours after
being deposited in the regular mail, as certified or registered mail (airmail if sent
internationally), with postage prepaid, addressed (a) if to the Registered Holder, to the address
of the Registered Holder most recently furnished in writing to the Company and (b) if to the
Company, to the address set forth below or subsequently modified by written notice to the
Registered Holder.

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     12. No Rights as Shareholder. Until the exercise of this Warrant, the Registered
Holder of this Warrant shall not have or exercise any rights by virtue hereof as a shareholder of
the Company.

     13. No Fractional Shares. No fractional shares of Preferred Stock will be issued in
connection with any exercise hereunder. In lieu of any fractional shares which would otherwise be
issuable, the Company shall pay cash equal to the product of such fraction multiplied by the fair
market value of one share of Preferred Stock on the date of exercise, as determined in good faith
by the Company’s Board of Directors.

     14. Amendment or Waiver. Any term of this Warrant may be amended or waived only by an
instrument in writing signed by the party against which enforcement of the amendment or waiver is
sought.

     15. Headings. The headings in this Warrant are for purposes of reference only and
shall not limit or otherwise affect the meaning of any provision of this Warrant.

     16. Governing Law. This Warrant shall be governed, construed and interpreted in
accordance with the laws of the State of Washington, without giving effect to principles of
conflicts of law.

	 	 	 
	 

	 	OMEROS CORPORATION
	 
	 	 
	 
	 	 
	 

	 	By: _________________________________
	 

	 	Name: _______________________________
	 

	 	Its: _________________________________

	 	 	 	 	 
	 

	 	Address:
	 	1420 Fifth Avenue, Suite 2600

Seattle, Washington 98101
	 
	 

	 	Fax Number:
	 	(206) 264-7856

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EXHIBIT A

PURCHASE FORM

	 	 	 
	 
	 	 
	To:    Omeros Corporation

	 	Dated:

     The undersigned, pursuant to the provisions set forth in the attached Warrant No. WE-
, hereby irrevocably elects to purchase _______________shares of the Series E Preferred Stock covered
by such Warrant and herewith makes payment of $____________, representing the full purchase price for
such shares at the price per share provided for in such Warrant.

     The undersigned acknowledges that it has reviewed the representations and warranties contained
in Section 4 of the Warrant and by its signature below hereby makes such representations and
warranties to the Company. Defined terms contained in such representations and warranties shall
have the meanings assigned to them in the Purchase Agreement, provided that the term
“Registered Holder” shall refer to the undersigned and the term “Securities” shall refer to the
Warrant Stock and the Common Stock of the Company issuable upon conversion of the Warrant Stock.

     The undersigned acknowledges that it has reviewed the market standoff provisions set forth in
Section 3(d) of the Warrant and agrees to be bound by such provisions.

     The undersigned further acknowledges that the Securities are subject to the stock transfer
restrictions set forth in Section 3 of the Amended and Restated Investors’ Rights Agreement dated
October 15, 2004 by and among the Company and the investors named therein, as such may be amended
from time to time (the “Rights Agreement”), including without limitation any transfer
restrictions set forth in any amendments to or restatements of Section 3 of the Rights Agreement.
The undersigned further acknowledges that it has received a copy of the Rights Agreement from the
Company (which the Company will provide upon request) or that it has voluntarily not requested a
copy of the Rights Agreement from the Company.

	 	 	 	 	 	 	 
	 

	 	Signature:	 	 	 	 
	 

	 	 	 	 

	 	 
	 

	 	Name (print):	 	 	 	 
	 

	 	 	 	 	 	 
	 
	 	 	 	 	 	 
	 

	 	Title (if applic.)	 	 	 	 
	 

	 	 	 	 	 	 
	 
	 	 	 	 	 	 
	 

	 	Company (if applic.):	 	 	 	 
	 

	 	 	 	 	 	 

 

 

EXHIBIT B

ASSIGNMENT FORM

     FOR VALUE RECEIVED, ____________hereby sells, assigns and transfers all of the
rights of the undersigned under the attached Warrant with respect to the number of shares of Series
E Preferred Stock covered thereby set forth below, unto:

	 	 	 	 	 	 	 
	Name of Assignee	 	 	Address/Fax Number	 	 	No. of Shares

	 	 	 	 	 	 	 	 
	Dated:

	 	 	Signature:	 	 	 	 
	 
	 

	 	 	 	 

	 	 
	 

	 	 	 	 	 	 	 
	 

	 	 	 	 	 

	 	 
	 

	 	 	Witness:

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