Document:

EX-10.45

 Exhibit 10.45 

CONFORMED COPY 
 WebMD
Health Corp. 
 395 Hudson St. 

New York, NY 10014 
 As of November 2, 2016

 Steven L. Zatz, M.D. 
 c/o WebMD Health Corp. 

395 Hudson St. – 4th Floor 
 New York, NY 10014 

Re:     Amended and Restated Employment Agreement 

Dear Steve: 
 This letter (“Letter
Agreement”) sets forth the terms of your continued employment with WebMD Health Corp. (the “Company” or “WebMD Health”), effective as of the date first above written (“Effective Date”), and replaces, in its
entirety, the Employment Agreement entered into between you and the Company, dated as of July 14, 2005, as amended (the “Prior Agreement”). 

1. Position and Responsibilities. As of September 19, 2016, you have served in the position of Chief Executive Officer of the Company. As Chief
Executive Officer, you report to the Board of Directors of the Company and assume and discharge such responsibilities as are commensurate with such position. During your employment with the Company, you will devote your full business time to your
duties and responsibilities and will perform them faithfully and diligently in accordance with the terms of this Letter Agreement, subject to permitted absence in accordance with the Company’s vacation policy. In addition, you will continue to
comply with and be bound by the operating policies, procedures and practices of the Company including, without limitation, the Code of Conduct, in effect from time to time during your employment. You will continue to report to the Company’s
headquarters located in New York, NY. You acknowledge that you are required to travel in connection with the performance of your duties but you will not be required to relocate outside the New York metropolitan area without your consent. 

2. Compensation. 
 (a) Effective as of
November 2, 2016, your base salary (“Base Salary”) will increase to $575,000 annually, payable in accordance with the Company’s prevailing payroll practices. 

(b) You will be eligible for an annual bonus, the target of which will continue to be 150% of your Base Salary, but which amount will be
determined in the sole discretion of the Compensation Committee, and which may include deferral of all or a portion of such bonus into the Company’s Supplemental Bonus Plan. Such bonus may be subject to the terms of a bonus plan that is
applicable to executive officers. Subject to Section 5(a), 5(b) (with respect to any bonuses awarded under the Company’s Supplemental Bonus Plan) and (d), the bonus will be paid when such bonuses are paid to other executive officers, so long as
you are employed on the payment date. 

 3. Other Benefits. You will continue to be entitled to receive the standard employee benefits made
available by the Company to its employees to the full extent of your eligibility. You will be entitled to vacation consistent with the Company’s vacation policy. During your employment, you will be permitted, to the extent eligible, to
participate in any group medical, dental, life insurance and disability insurance plans, or similar benefit plan of the Company that is available to employees generally. Participation in any such plan will be consistent with your rate of
compensation to the extent that compensation is a determinative factor with respect to coverage under any such plan. The Company will reimburse you for all reasonable expenses actually incurred or paid by you in the performance of your services on
behalf of the Company, upon prior authorization and approval in accordance with the Company’s expense reimbursement policy as from time to time in effect. 

4. WebMD Health Equity. 
 (a) On
November 2, 2016 (the “2016 Equity Grant Date”), the Compensation Committee approved and you were granted a nonqualified option (the “2016 Stock Option”) to purchase 150,000 shares of WebMD Health’s common stock under
the terms of the WebMD Health Corp. Amended and Restated 2005 Long Term Incentive Plan (the “Equity Plan”). The per share exercise price is equal to the closing price of the Company’s common stock on the 2016 Equity Grant Date. One
third of the 2016 Stock Option will vest on each of the second, third and fourth anniversary of the 2016 Equity Grant Date, subject to your continued employment on such vesting date, except as provided in Section 5(b). The 2016 Stock Option
will have a term of ten (10) years, subject to earlier termination in the event of termination of employment in accordance with the Equity Plan and subject to Section 5(b). The 2016 Stock Option will be evidenced by the Company’s form of
option agreement. 
 (b) On the 2016 Equity Grant Date, the Compensation Committee approved and you were granted 30,000 shares of restricted
stock of WebMD Health (the “2016 Restricted Stock Grant”) under the terms of the Equity Plan. One-third of the 2016 Restricted Stock Grant shall vest and the restrictions thereon lapse on each of the
second, third and fourth anniversary of the 2016 Equity Grant Date, subject to your continued employment on each such vesting date and subject to Section 5(b). The 2016 Restricted Stock Grant will be evidenced by the Company’s form of
restricted stock agreement. 
 (c) On the 2016 Equity Grant Date, the Compensation Committee approved and you were granted, 30,000 shares of
WebMD Health performance-based restricted stock (the “2016 Performance-Based Restricted Stock Grant”) under the terms of the Equity Plan. The 2016 Performance-Based Restricted Stock Grant will vest and the restrictions thereon lapse based
on the achievement of specified performance goals established by the Compensation Committee and separately communicated to you, subject to your continued employment on the last day of the performance cycle, December 31, 2019, except as provided
in Section 5(b). The 2016 Performance-Based Restricted Stock Grant will be evidenced by the Performance-Based Restricted Stock Award Agreement separately provided to you. 

(d) The parties acknowledge that Executive continues to hold prior grants of options and restricted stock and they remain in effect in
accordance with their terms, subject to Section 5 below. 

  
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 5. Termination of Employment. 

(a) In the event of the termination of your employment by the Company without Cause or by you for Good Reason (as such terms are defined on
Annex A attached hereto), subject to Section 5(d) below and your continued compliance with your Restrictive Covenant Agreements (as defined below), (i) you will continue to receive, as severance, your Base Salary in effect on the date of
such termination for a period of twelve (12) months; (ii) if you timely elect to continue your health coverage through COBRA, the Company will reimburse you for the cost of your COBRA for a period of twelve (12) months from the date
of termination, or, if earlier, until such time as you are no longer eligible for COBRA or are otherwise eligible for comparable coverage with a subsequent employer, which reimbursement shall be made within thirty (30) days after you provide
evidence of your payment of such premiums, which evidence shall be provided no later than thirty (30) days after payment, and which reimbursement shall be treated as a taxable bonus; and (iii) if your termination date is effective on or
after July 1 of any calendar year but before the payment of bonuses for any such year, you shall be entitled to the bonus that you would have received for such year at the time that bonuses are paid to other executive officers of the Company,
but in no event later than March 15 of the year following the year to which the bonus relates. You shall promptly notify the Company if you become eligible for comparable coverage with another employer as described in Section

5(a)(ii) above. 
 (b) In the event of the termination of your employment without Cause or by you for Good Reason, in each case,
following a Change of Control of WebMD Health (as defined below), in addition to the payments set forth in Section 5(a) above and subject to Section 5(d) below and your continued compliance with your Restrictive Covenant Agreements, (i) you
shall be entitled to receive the amount held (if any) on your behalf in the Company’s Supplemental Bonus Plan and Trust within 10 business days of the effectiveness of the Release specified in Section 5(d) and (ii) all of your Existing
Equity (as defined on Annex A) which remains outstanding at the time of such termination will be deemed fully vested on the date of termination, and the Existing Options (as defined on Annex A) shall remain outstanding as if you remained in the
employ of the Company through the first anniversary of the date of termination (but no longer than the originally scheduled expiration date), other than the option granted on March 25, 2015 which, in such event, shall remain outstanding through
the expiration of the originally scheduled term consistent with the original terms of such grant. Upon a Change of Control of WebMD Health, the Performance Share Award shall be treated as fully satisfying the Performance Criteria specified therein.
The term “Change of Control of WebMD Health” shall have the meaning ascribed to such term in the Equity Plan. 
 In addition, you
may resign your employment without Good Reason at any time following the one year anniversary of a Change of Control of WebMD Health and receive the payments and benefits set forth above in Section 5(b) other than the option and restricted stock
grants made on March 25, 2015 (for the sake of clarity, the vesting of such grants will accelerate if terminated without Cause or for Good Reason following a Change of Control but will not be accelerated and the option will not have the longer
post termination exercise period if you resign following the one year anniversary of a Change of Control without Good Reason (in that event, it is treated as a standard resignation), subject to Section 5(d) and your continued compliance with
all Restrictive Covenant Agreements. 

  
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 (c) In the event of termination of your employment for any reason other than by the Company
without Cause or by you for Good Reason (or as provided in the second paragraph of Section 5(b)), you will receive compensation earned through the date of termination and your rights with respect to your stock option and restricted stock grants
(including the 2016 Performance-Based Restricted Stock Grant) will be as specified in the applicable option or restricted stock agreements. 

(d) In order to receive any of the benefits described in Section 5(a) or 5(b) under this Letter Agreement (the “Severance
Benefits”), you must (i) execute and deliver to the Company a release of claims satisfactory to the Company (but which will not require release of any Company payments due to you that are otherwise payable at the date of termination of
this Letter Agreement) within the time prescribed therein but in no event later than fifty (50) days of the date of your termination of employment and (ii) not revoke such release pursuant to any revocations rights afforded by law. The
Company shall provide to you the form of release no later than three (3) days following your termination of employment. If you do not timely execute and deliver to the Company such release, or if you execute such release but revoke it, no
Severance Benefits shall be paid. 
 (e) The Severance Benefits described in Section 5(a)(i) above shall be paid, minus applicable
deductions, including deductions for tax withholding, in equal payments on the regular payroll dates during the one-year period following your termination of employment. Commencement of payments of the
Severance Benefits described in Section 5(a)(i) shall begin on the first payroll date that occurs in the month that begins at least 60 days after the date of your termination of employment, but which may be accelerated by no more than 30 days
(the “Starting Date”); provided that you have satisfied the requirements of Section 5(d) of this Letter Agreement. The first payment on the payment Starting Date shall include those payments that would have previously been paid if the
payments of the Severance Benefits described in Section 5(a)(i) had begun on the first payroll date following your termination of employment. This timing of the commencement of benefits is subject to Section 6 below. 

(f) For purposes of this Letter Agreement, “termination of employment” shall mean a “separation of service” as defined in
Section 409A of the Internal Revenue Code of 1986, as amended, (the “Code”) and Treasury Regulations Section 1.409A-I(h) without regard to the optional alternative definitions available thereunder. 

(g) All Severance Benefits shall be completed by, and no further Severance Benefits shall be payable after, December 31 of the second
taxable year following the year in which your termination of employment occurs. 
 (h) Your entitlement to the payments of the Severance
Benefits described in Section 5(a)(i) shall be treated as the entitlement to a series of separate payments for purposes of Section 409A of the Code. 

(i) In the event of the termination of your employment for any reason, you shall immediately be deemed to have resigned from any and all
officer or director positions of the Company (or any subsidiary or affiliate thereof) in which you serve. 

  
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 6. Section 409A. 

(a) Potential Six-Month Delay. Notwithstanding any other provisions of the Letter Agreement,
any payment of the Severance Benefits under this Letter Agreement that the Company reasonably determines is subject to Section 409A(a)(2)(B)(i) of the Code shall not be paid or payment commenced until the later of (i) six (6) months
after the date of your termination of employment (or, if earlier, your death) and (ii) the Starting Date. On the earliest date on which such payments can be commenced without violating the requirements of Section 409A(a)(2)(B)(i) of the Code,
you shall be paid, in a single cash lump sum, an amount equal to the aggregate amount of all payments delayed pursuant to the preceding sentence. 

(b) Savings Clause. It is intended that any amounts payable under this Letter Agreement shall either be exempt from or comply with
Section 409A of the Code (including Treasury regulations and other published guidance related thereto) so as not to subject you to payment of any additional tax, penalty or interest imposed under Section 409A of the Code. The provisions of
this Letter Agreement shall be construed and interpreted to avoid the imputation of any such additional tax, penalty or interest under Section 409A of the Code yet preserve (to the nearest extent reasonably possible) the intended benefit
payable to you. Notwithstanding the foregoing, the Company makes no representation or warranty and shall have no liability to you or to any other person if any of the provisions of this Letter Agreement are determined to constitute deferred
compensation subject to Section 409A, but that do not satisfy an exemption from, or the conditions of, that section. 
 7. Restrictive
Covenants. As a condition to the effectiveness of this Letter Agreement, you will be required to sign the attached the Restrictive Covenant Agreement. You acknowledge that you continue to be bound by and will comply with the Trade Secret and
Proprietary Information Agreement (“TSPI”) annexed to your Prior Agreement (which TSPI shall survive the termination of the Prior Agreement), and all such similar TSPI or Restrictive Covenant Agreements that are annexed to any equity
agreement to which you are bound (collectively with the Restrictive Covenant Agreement attached hereto, the “Restrictive Covenant Agreements”). 

8. Conflicting Employment. You agree that, during your employment with the Company, you will not engage in any other employment, occupation, consulting
or other business activity directly related to the business in which the Company is now involved or becomes involved during your employment, nor will you engage in any other activities that conflict with your obligations to the Company. With the
prior written approval of the Company, which will not be unreasonably withheld, you may serve on the Board of Directors of other companies, and provided that such service does not affect or conflict with the services to be provided under this
Agreement. 
 9. At-Will Employment. You acknowledge that your employment with the Company is for an
unspecified duration that constitutes at-will employment, and that either you or the Company can terminate this relationship at any time, with or without Cause and with or without notice, subject to the
consequences set forth in this Letter Agreement. 
 10. General Provisions. 

(a) You will be covered by the Company’s director and officer insurance policy to the same extent as other similarly situated employees
of the Company. 

  
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 (b) This Letter Agreement and the terms of your employment will be governed by the laws of New
York, applicable to agreements made and to be performed entirely within such state and the courts sitting in New York, New York shall have exclusive jurisdiction for the purposes of adjudicating any disputes under this Letter Agreement. 

(c) This Letter Agreement (including its Annexes) as well as the Equity Plan, equity agreements and Restrictive Covenant Agreements referenced
herein, set forth the entire agreement and understanding between the Company and you relating to its subject matter and supersede all verbal discussions and prior agreements (except as otherwise set forth herein) between us. 

(d) This Letter Agreement will be binding upon your heirs, executors, administrators and other legal representatives and will be for the
benefit of the Company and its permitted successors and assigns. 
 (e) All payments pursuant to this Letter Agreement will be subject to
applicable withholding taxes. 
 (f) This Letter Agreement may not be assigned by the Company without your prior written consent; provided
however that this Letter Agreement may be assigned by the Company without your prior written consent to any successor to the business of the Company, by operation of law, merger or otherwise or to any affiliate of the Company. 

Please acknowledge and confirm your acceptance of this amendment and restatement of your employment agreement by signing and returning one
copy of this Letter Agreement and the Restrictive Covenant Agreement to Douglas W. Wamsley, Executive Vice President, Co-General Counsel, WebMD Health Corp., 395 Hudson St. – 3rd Floor, New York, NY
10014. 
 WebMD Health Corp. 
  

	
	     /s/ Douglas W. Wamsley

	By: Douglas W. Wamsley

 ACCEPTANCE: 
 I accept the
revised terms of my continued employment with WebMD Health Corp. as set forth herein. I understand that this Letter Agreement does not constitute a contract of employment for any specified period of time, and that either party, with or without Cause
and with or without notice, may terminate my employment relationship (subject to the consequences set forth above). 
  

	
	     /s/ Steven L. Zatz, M.D.

	Steven L. Zatz, M.D.

  

	
	     11/3/16

	Date Signed

  
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 ANNEX A 

“Cause ” will mean any of the following: 

(i) your willful failure to perform your duties following written notice from the Company detailing the specific acts and a thirty
(30) day period of time to remedy such failure; 
 (ii) any willful misconduct, violence or threat of violence that is injurious to the
Company in a material respect or any misconduct relating to your business affairs, at any time, which will demonstrably reflect negatively upon the Company or otherwise impair or impede its operations or reputation in any material respect; 

(iii) your breach of a material Company policy, which breach is not remedied (if susceptible to remedy) following written notice by the
Company detailing the specific breach and a thirty (30) day period of time to remedy such breach; 
 (iv) any material breach by you of
this Letter Agreement or the Restrictive Covenant Agreements, which breach is not remedied (if susceptible to remedy) following written notice by the Company or its designee detailing the specific breach and a thirty (30) day period of time to
remedy such breach; 
 (v) your conviction of a felony in respect of a dishonest or fraudulent act or other crime of moral turpitude. 

“Existing Equity” means all of the Existing Options, all of the shares of restricted Common Stock and the Performance Share Grant
held by you as of the date of this Agreement, including the grants made on the 2016 Equity Grant Date. 
 “Existing Options” means
all of the options to purchase shares of WebMD Health held by you as of the date of this Agreement, including the options granted to you on the 2016 Equity Grant Date. 

A termination of employment by you for “Good Reason” means your resignation of employment within one (1) year of the
occurrence (without your written consent) of any of the following conditions or events: (i) any material reduction in your base salary, (ii) the Company removing you from the position of Chief Executive Officer, (iii) any material
breach by the Company of this Letter Agreement; provided, however, that none of the foregoing conditions or events shall constitute Good Reason unless (A) you shall have provided written notice to the Company within ninety (90) days after
the occurrence of such condition or event describing the condition or event claimed to constitute Good Reason and (B) the Company shall have failed to remedy the condition or event within thirty (30) days of its receipt of such written
notice; provided, however, that notwithstanding anything to the contrary, you shall not have Good Reason and it shall not be considered a breach of this Agreement if on or following a Change of Control, you are not serving in the position of Chief
Executive Officer so long as you are engaged in transitional responsibilities and duties or otherwise serve in a senior capacity. 

 ANNEX B 

RESTRICTIVE COVENANT AGREEMENT 
 In
consideration of my employment with WebMD Health Corp. and/or any of its corporate parents, subsidiaries, divisions, or affiliates, or the successors or assigns of any of the foregoing (hereinafter referred to as the “Company”), I hereby
agree as follows: 
 1. Confidentiality. 

a) Trade Secret and Proprietary Information. I understand and acknowledge that, during the course of my employment with the
Company and as a result of my having executed this Restrictive Covenant Agreement (“Agreement”), I will be granted access to valuable information relating to the business of the Company that provides the Company with a competitive
advantage (or that could be used to the disadvantage of the Company by a Competitive Business) (as defined herein), which is not generally known by, nor easily learned or determined by, persons outside the Company (collectively “Trade Secret
and Proprietary Information”). The term “Trade Secret and Proprietary Information” shall include, but shall not be limited to: (a) specifications, manuals, software in various stages of development; (b) customer and
prospect lists, and details of agreements and communications with customers and prospects; (c) sales plans and projections, product pricing information, acquisition, expansion, marketing, financial and other business information and existing
and future products and business plans of the Company; (d) sales proposals, demonstrations systems, sales material; (e) research and development; (f) computer programs; (g) sources of supply; (h) identity of specialized
consultants and contractors and Trade Secret and Proprietary Information developed by them for the Company; (i) purchasing, operating and other cost data; (j) special customer needs, cost and pricing data; (k) employee information
(including, but not limited to, personnel, payroll, compensation and benefit data and plans); and (l) patient information, including without limitation Protected Health Information as defined in 45 C.F.R. 164.50, including all such information
recorded in manuals, memoranda, projections, reports, minutes, plans, drawings, sketches, designs, formula books, data, specifications, software programs and records, whether or not legended or otherwise identified by the Company as Trade Secret and
Proprietary Information, as well as such information that is the subject of meetings and discussions and not recorded. Trade Secret and Proprietary Information shall not include such information that I can demonstrate (i) is generally
available to the public (other than as a result of a disclosure by me), (ii) was disclosed to me by a third party under no obligation to keep such information confidential or (iii) was known by me prior to, and not as a result of, my employment
or anticipated employment with the Company. 
 b) Duty of Confidentiality. I agree at all times, both during and after my
employment with the Company, to hold all of the Trade Secret and Proprietary Information in a fiduciary capacity for the benefit of the Company and to safeguard all such Trade Secret and Proprietary Information. I also agree that I will not
directly or indirectly disclose or use any such Trade Secret and Proprietary Information to any third person or entity outside the Company, except as 

 
may be necessary in the good faith performance of my duties for the Company. I further agree that, in addition to enforcing this restriction, the Company may have other rights and remedies
under the common law or applicable statutory laws relating to the protection of trade secrets. Notwithstanding anything in this Agreement to the contrary, I understand that I may disclose the Trade Secret and Proprietary Information (i) to
the extent required by applicable laws or governmental regulations or judicial or regulatory process, provided that I give the Company prompt notice of any and all such requests for disclosure so that it has ample opportunity to take all necessary
or desired action, to avoid disclosure, unless such notice is prohibited by law and (ii) in connection with reporting any possible violation of law or regulation to any governmental agency charged with enforcing any laws, without having to get
prior authorization from or give notice to the Company. 
 In accordance with the Defend Trade Secrets Act of 2016 and notwithstanding
anything in this Agreement to the contrary, I understand that I will not be held criminally or civilly liable under any federal or state trade secret law for any disclosure of a trade secret that: (i) is made in confidence to a federal, state,
or local government official, either directly or indirectly, or to an attorney, if solely for the purpose of reporting or investigating a suspected violation of law, or (ii) is made in a complaint or other document that is filed under seal in a
lawsuit or other proceeding. In addition, if I file a lawsuit for retaliation by the Company for reporting a suspected violation of law, I may disclose the Company’s trade secrets to my attorney and use such information in the court proceeding
if I (i) file any document containing the trade secret under seal, and (ii) do not disclose the trade secret, except pursuant to court order. 

c) Company Property. I acknowledge that: (i) all Trade Secret and Proprietary Information of the Company,
(ii) computers, and computer-related hardware and software, cell phones, beepers and any other equipment provided to me by the Company, and (iii) all documents I create or receive in connection with my employment with the Company, belong
to the Company, and not to me personally (collectively, “Company Property”). Such documents include, without limitation and by way of non-exhaustive example only: papers, files, memoranda,
notes, correspondence, lists, e-mails, reports, records, data, research, proposals, specifications, models, flow charts, schematics, tapes, printouts, designs, graphics, drawings, photographs, abstracts,
summaries, charts, graphs, notebooks, investor lists, customer/client lists, and all other compilations of information, regardless of how such information may be recorded and whether in printed form or on a computer or magnetic disk or in any other
medium. I agree to return all Company Property (including all copies) to the Company immediately upon any termination of my employment, and further agree that, during and after my employment with the Company, I will not, under any
circumstances, without the Company’s specific written authorization in each instance, directly or indirectly disclose Company Property or any information contained in Company Property to anyone outside the Company, or otherwise use Company
Property for any purpose other than the advancement of the Company’s interests. 
 d) Unfair Competition. I acknowledge
that the Company has a compelling business interest in preventing unfair competition stemming from the intentional or inadvertent use or disclosure of the Company’s Trade Secret and Proprietary Information and Company Property. 

  
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 e) Investors, Other Third-Parties, and Goodwill. I acknowledge that all
third-parties (e.g., customers, vendors, investors and advertisers) I service or propose to service while employed by the Company are doing business with the Company and not me personally, and that, in the course of dealing with such third-parties,
the Company establishes goodwill with respect to each such third-party that is created and maintained at the Company’s expense (“Third-Party Goodwill”). I also acknowledge that, by virtue of my employment with the Company, I have
gained or will gain knowledge of the business needs of, and other information concerning, third-parties, and that if such information were used to solicit or service any such third-parties on my own behalf or on behalf of a Competitive Business (as
defined herein), the Company would be competitively disadvantaged. 
 f) Intellectual Property and Inventions. I acknowledge
that all developments, including, without limitation, the creation of new products, conferences, training/seminars, publications, programs, methods of organizing information, inventions, discoveries, concepts, ideas, improvements, patents,
trademarks, trade names, copyrights, trade secrets, designs, works, reports, computer software, flow charts, diagrams, procedures, data, documentation, and writings and applications thereof relating to the past, present, or future business of the
Company that I, alone or jointly with others, may have discovered, conceived, created, made, developed, reduced to practice, or acquired during my employment with the Company (collectively, “Developments”) are works made for hire and shall
remain the sole and exclusive property of the Company, and I hereby assign to the Company all of my rights, titles, and interest in and to all such Developments, if any. I agree to disclose to the Company promptly and fully all future
Developments and, at any time upon request and at the expense of the Company, to execute, acknowledge, and deliver to the Company all instruments that the Company shall prepare, to give evidence, and to take any and all other actions that are
necessary or desirable in the reasonable opinion of the Company to enable the Company to file and prosecute applications for, and to acquire, maintain, and enforce, all letters patent, trademark registrations, or copyrights covering the Developments
in all countries in which the same are deemed necessary by the Company. All data, memoranda, notes, lists, drawings, records, files, investor and client/customer lists, supplier lists, and other documentation (and all copies thereof) made or
compiled by me or made available to me concerning the Developments or otherwise concerning the past, present, or planned business of the Company are Company Property, and will be delivered to the Company immediately upon the termination of my
employment with the Company. 
 2. Covenant Not to Compete with the Company. 

a) I acknowledge that the business of the Company can be conducted anywhere in the world and is not limited to a geographic scope or
region, that its products, programs and services are marketed throughout the United States, Canada, Europe, Asia, Latin America and other geographic regions throughout the world, that the Company competes in nearly all of its business activities
with other individuals or entities that are, or could be, located in nearly any part of the world and that the nature of my services, position, and expertise are such that I am capable of competing with the Company from nearly any location in the
world. 

  
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 b) Accordingly, in order to protect the Company’s Trade Secret and Proprietary
Information and Third-Party Goodwill, I acknowledge and agree that during my employment with the Company and for a period of one year after the date my employment with the Company is terminated for any reason (the “Restricted Period”), I
will not, without the Company’s express written permission, directly or indirectly (including through the Internet), own, control, manage, operate, participate in, be employed by, or act for or on behalf of (as principal, agent, employee,
consultant, director or otherwise), any “Competitive Business” (as defined herein) located anywhere within the geographic boundaries of the United States, Canada, Europe, Asia, Latin America and the world. 

c) For purposes of this Agreement “Competitive Business” will mean: (i) any enterprise engaged in developing, selling or
providing (via the internet or other means) health or wellness information, decision support tools or services or applications and/or communication services, directly or indirectly, to consumers, health and/or benefit plan members or employees or
healthcare professionals, including but not limited to products or services that provide information on diseases, conditions or treatments, store health care information, assess personal health status, and/or assist in making informed benefit,
provider or treatment choices; and (ii) any enterprise engaged in any other type of business in which the Company is also engaged, or plans to be engaged, so long as I am directly involved in such business or planned business on behalf of the
Company. Notwithstanding the foregoing, I understand that I may have an interest consisting of publicly traded securities constituting less than 1 percent of any class of publicly traded securities in any public company engaged in a
Competitive Business, so long as I am not employed by, do not consult with, or become a director of or otherwise engage in any activities for, such company. 

3. Non-Solicitation of Employees, Customers. In order to protect the Company’s Trade Secret and
Proprietary Information and Third-Party Goodwill, during the Restricted Period, I will not, without the Company’s express written permission, directly or indirectly: 

a) solicit, induce, hire, engage, or attempt to hire or engage any employee or independent contractor of the Company, or in any other way
interfere with the Company’s employment or contractual relations with any of its employees or independent contractors, nor will I solicit, induce, hire, engage or attempt to hire or engage any individual who was an employee of the Company
at any time during the one (1) year period immediately prior to the termination of my employment with the Company; and 

b) contact, call upon, encourage or solicit, on behalf of a Competitive Business, any existing or prospective client, or customer of the
Company who I serviced, or otherwise developed a relationship with, or about whom I obtained confidential information as a result of my employment with the Company, nor will I attempt to divert or take away from the Company the business of any such
client or customer. 
 4. Injunctive Remedies. I acknowledge and agree that the restrictions contained in this Agreement are reasonably
necessary to protect the legitimate business interests of the Company, and that any violation of any of the restrictions will result in immediate and irreparable injury to the Company for which monetary damages will not be an adequate remedy. I
further 

  
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acknowledge and agree that if any such restriction is violated, the Company will be entitled to immediate relief enjoining such violation (including, without limitation, temporary and permanent
injunctions, a decree for specific performance, and an equitable accounting of earnings, profits, and other benefits arising from such violation) in any court having jurisdiction over such claim, without the necessity of showing any actual damage or
posting any bond or furnishing any other security, and that the specific enforcement of the provisions of this Agreement will not diminish my ability to earn a livelihood or create or impose upon me any undue hardship. I also agree that any
request for such relief by the Company shall be in addition to, and without prejudice to, any claim for monetary damages that the Company may elect to assert. In addition, the Restricted Period shall be extended for a period of time equal to
the period of time during which I breached the restrictions contained herein. 
 5. Severability Provision. I acknowledge and agree that the
restrictions imposed upon me by the terms, conditions, and provisions of this Agreement are fair, reasonable, and reasonably required for the protection of the Company. In the event that any part of this Agreement is deemed invalid, illegal, or
unenforceable, all other terms, conditions, and provisions of this Agreement shall nevertheless remain in full force and effect. In the event that the provisions of any of Sections 1, 2, or 3 of this Agreement relating to the geographic area of
restriction, the length of restriction or the scope of restriction shall be deemed to exceed the maximum area, length or scope that a court of competent jurisdiction would deem enforceable, said area, length or scope shall, for purposes of this
Agreement, be deemed to be the maximum area, length of time or scope that such court would deem valid and enforceable, and that such court has the authority under this Agreement to rewrite (or “blue-pencil”) the restriction(s) at-issue to achieve this intent. 
 6. Non-Waiver. Any waiver by
the Company of my breach of any term, condition, or provision of this Agreement shall not operate or be construed as a waiver of the Company’s rights upon any subsequent breach. 

7. Waiver of Jury Trial. TO THE MAXIMUM EXTENT PERMITTED BY LAW, I HEREBY KNOWINGLY, VOLUNTARILY, AND INTENTIONALLY WAIVE THE RIGHT TO A
TRIAL BY JURY IN CONNECTION WITH ANY LITIGATION ARISING OUT OF, UNDER, IN CONNECTION WITH, OR IN ANY WAY RELATED TO THIS AGREEMENT. THIS INCLUDES, WITHOUT LIMITATION, ANY LITIGATION CONCERNING ANY COURSE OF CONDUCT, COURSE OF
DEALING, STATEMENT (WHETHER VERBAL OR WRITTEN), OR ACTION OF THE COMPANY OR ME, OR ANY EXERCISE BY THE COMPANY OR ME OF OUR RESPECTIVE RIGHTS UNDER THIS AGREEMENT OR IN ANY WAY RELATING TO THIS AGREEMENT. I FURTHER ACKNOWLEDGE
THAT THIS WAIVER IS A MATERIAL INDUCEMENT FOR THE COMPANY TO ISSUE AND ACCEPT THIS AGREEMENT. 
 8. Notice to Future Employers. For a period
of two (2) years after my employment with the Company ends, I will inform each new employer, prior to accepting employment, of the existence and details of the covenants contained in this Annex A and will provide each such employer with a copy
of this Annex. 

  
 5 

 9. Assignment. The Company shall have the right to assign its rights and obligations under this Annex
A without my consent. I acknowledge that I may not assign my obligations herein. 
 RESTRICTIVE COVENANT AGREEMENT ACCEPTANCE 

I understand and accept the restrictions and obligations imposed upon me by the terms, conditions, and provisions set forth in this Restrictive Covenant
Agreement and agree to abide by same. 
  

	
	     /s/ Steven L. Zatz, M.D.

	Steven L. Zatz, M.D.

  
 6EX-10.46

 Exhibit 10.46 

CONFORMED COPY 
  

									
		  		  		  	

	  	 395 Hudson Street
 3rd Floor
 New York, NY 10014

212.624.3700

 As of November 2, 2016 

Michael B. Glick 
 c/o WebMD Health Corp. 

395 Hudson St. – 3rd Floor 
 New York, NY 10014 

Dear Mike: 
 Reference is made to the grant of
(i) a nonqualified option to purchase 75,000 shares of WebMD Health Corp.’s (the “Company”) Common Stock made to you on November 2, 2016 (the “2016 Option”) as evidenced by the Option Agreement dated
November 2, 2016 (the “Option Agreement”) and (ii) 15,000 shares of the Company’s restricted Common Stock made to you on the same date (the “2016 Restricted Stock Grant” and collectively with the 2016 Option, the
“2016 Grants”) and evidenced by a Restricted Stock Agreement dated November 2, 2016 (the “Restricted Stock Agreement”). 
  

	1.	Impact of Certain Terminations following a Change of Control. Notwithstanding anything to the contrary contained in the Option Agreement or the Restricted Stock Agreement, in the event of the termination
of your employment by the Company without Cause or by you for Good Reason (as such terms are defined in your Employment Agreement with the Company dated February 11, 2011, as amended, (the “Employment Agreement”)), in either case
following a Change of Control of the Company (as defined in the Company’s Amended and Restated 2005 Long-Term Incentive Plan): 

  

	 	(a)	the 2016 Option, to the extent unvested, shall be deemed vested on the date of termination and shall remain outstanding as if you remained in the employ of the Company through the one year anniversary of the date of
termination (but in no event later than the expiration of the originally scheduled term of the 2016 Option); and 

  

	 	(b)	the 2016 Restricted Stock Grant, to the extent unvested, shall be deemed vested on the date of termination. 

The acceleration of vesting of the 2016 Grants and the continued exercisability of the 2016 Option are expressly conditioned on (i) a
release of claims (as described in the Employment Agreement) being executed by you and becoming effective and (ii) your continued compliance with the restrictive covenant agreements you have signed in connection with your employment. 

	2.	Salary Increase. Effective November 3, 2016, your Base Salary is $375,000. 

  

	3.	Effect on Agreements. Except as set forth herein, the Employment Agreement, Option Agreement and the Restricted Stock Agreement remain in full force and effect. 

Sincerely, 
 WEBMD HEALTH CORP 

 

			
	 By:
	 	     /s/ Lewis H. Leicher

		 	Lewis H. Leicher
		 	Senior Vice President

 Agreed to: 
  

	
	     /s/ Michael B. Glick

	Michael B. Glick

  
 2

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