Document:

Development Agreement

 Exhibit 10.18 
  

			
	Certain confidential information contained in this document, marked by brackets and asterisks, has been omitted pursuant to a request for confidential treatment pursuant to 17
C.F.R. Sections 200.80(b)(4), 200.83 and 230.406, and has been filed separately with the Securities and Exchange Commission

  
 DEVELOPMENT
AGREEMENT 
  
 THIS DEVELOPMENT AGREEMENT (this
“Agreement”) is entered into as of May 3, 2004 (the “Effective Date”) by and between ACADIA PHARMACEUTICALS INC., a Delaware corporation
(“ACADIA”), with offices at 3911 Sorrento Valley Blvd., San Diego, California 92121, and THE STANLEY MEDICAL RESEARCH INSTITUTE,
a nonprofit organization (“SMRI”), having offices at 5430 Grosvenor Lane, Suite 200, Bethesda, Maryland 20814. 
  
 RECITALS 
  
 WHEREAS, ACADIA is a leader in the discovery and development of small molecule drugs to treat disorders of the central nervous
system with a primary focus on the development of innovative schizophrenia therapeutics; 
  
 WHEREAS, SMRI is the world’s leading nonprofit organization that supports research on the causes and treatment of schizophrenia and bipolar disorder, both through its own laboratories and
support of researchers worldwide; and 
  
 WHEREAS, SMRI desires to support the further development and commercialization of the Compound (as defined below) in order to accelerate the introduction of a novel therapy for the benefit of schizophrenia patients
worldwide. 
  
 NOW,
THEREFORE, in consideration of the foregoing and the covenants and premises contained in this Agreement, the parties agree as follows: 
  
 1. DEFINITIONS. As used herein, the following terms shall have the following meanings: 
  
 1.1 “ACADIA Product” shall mean any product
containing the Compound which receives Regulatory Approval and is commercialized by ACADIA or its Affiliates or Licensees, including all formulations and modes of administration thereof. 
  
 1.2 “Affiliate” shall mean any company or entity controlled by, controlling, or under common control
with a party hereto and shall include any company or entity of which greater than fifty percent (50%) of the voting stock or participating profit interest of which is owned or controlled, directly or indirectly, by a party, and any company or entity
which owns or controls, directly or indirectly, greater than fifty percent (50%) of the voting stock of a party. 
  
 1.3 “Applicable Rate” shall mean the prime rate published in The Wall Street Journal, Western U.S. Edition, from time to
time plus five (5) percentage points. 
  
 1.4
“Compound” shall mean ACP-104 (N-desmethylclozapine, norclozapine) and its salts. 
  
 1.5 “Confidential Information” shall mean all information disclosed by a party to the other pursuant to this Agreement including,
without limitation, manufacturing, marketing, financial, personnel, scientific and other business information and plans, and the material terms of this Agreement, whether in oral, written, graphic or electronic form. 
  

 1. 

 1.6 “Development Advisory Committee” or “DAC” shall mean the
committee formed pursuant to Section 3.1. 
  
 1.7
“Development Plan” shall mean the plan for conducting the Development Program, including a budget, prepared by ACADIA on an annual basis during the Development Term, as may be amended from time to time by ACADIA pursuant to
Section 2.2. 
  
 1.8 “Development Program”
shall mean the research and development program with respect to the Compound conducted during the Development Term. 
  
 1.9 “Development Term” shall mean the three (3) years following the Effective Date, as may be extended for additional, consecutive
one (1) year periods by written agreement of the parties. 
  
 1.10 “Disclosing Party” shall have the meaning provided in Section 8.1. 
  
 1.11 “First Commercial Sale” of an ACADIA Product shall mean the first sale for use or consumption of such ACADIA Product in a
country after Regulatory Approval has been granted by the governing health regulatory authority of such country. Sale to an Affiliate or Licensee shall not constitute a First Commercial Sale unless the Affiliate or Licensee is the end user of the
ACADIA Product. 
  
 1.12 “First Maximum”
shall have the meaning provided in Section 4.2(b)(i). 
  
 1.13
“Indemnitee” shall have the meaning provided in Section 9.1. 
  
 1.14 “Inventions” shall have the meaning provided in Section 6.1(b). 
  
 1.15 “Licensee” shall mean any Third Party who has obtained a license to sell ACADIA Products from ACADIA. 
  
 1.16 “License Grant” shall have the meaning provided
in Section 6.2(a). 
  
 1.17 “Net Sales”
shall mean, with respect to any ACADIA Product, the amount invoiced for the sale of such ACADIA Product by ACADIA and its Affiliates or its Licensees, as applicable, to Third Parties which are not Affiliates or sublicensees of the selling party,
unless such Affiliates or sublicensees are the end users of such ACADIA Product in which case the amount billed therefor shall be deemed to be the amount that would be invoiced to a Third Party in an arm’s length transaction, less: 

 
 (a) cash discounts and/or quantity discounts allowed; 

 
 (b) credits and allowances for returns, rejections and recalls;

  
 (c) charges for freight, insurance and transportation
specifically included in the amount invoiced 
  
 (d) sales
and use taxes, duties or other governmental tariffs and other similar taxes incurred and government mandated rebates; and 
  

 2. 

 (e) accruals for estimated wholesaler chargebacks, contract rebates and bid rebates and Medicaid
and other similar government mandated rebates as ACADIA may be required to pay from time to time, all of which shall be determined in accordance with ACADIA’s standard accounting methods. 
  
 1.18 “Note” shall have the meaning provided in
Section 4.1(a). 
  
 1.19 Proprietary Rights”
shall have the meaning provided in Section 6.1(b). 
  
 1.20
“Receiving Party” shall have the meaning provided in Section 8.1. 
  
 1.21 “Regulatory Approval” shall mean any and all approvals (including price and reimbursement approvals), licenses, registrations, or authorizations of the United States or European Union or
any country, federal, state or local regulatory agency, department, bureau or other government entity that is necessary for the manufacture, use, storage, import, transport and/or sale of a product in a given jurisdiction. 
  
 1.22 “Royalty Term” shall mean the period of time
commencing on the First Commercial Sale of any ACADIA Product and ending upon the termination of ACADIA’s payment obligations under Section 4.2 or the twenty-fourth (24th) anniversary of the Effective Date, whichever is earlier. 
  
 1.23 “Second Maximum” shall have the meaning set
forth in Section 4.2(b)(ii). 
  
 1.24 “Strategic
Alliance” shall mean an agreement entered into by ACADIA with a Third Party with respect to the development of the Compound, but excluding an agreement with a Third Party with respect to only the manufacturing, sale and/or promotion of the
Compound and/or ACADIA Products or for the transfer or sale of all or substantially all of the business of ACADIA to which this Agreement relates to an Affiliate or Third Party, whether by merger, sale of stock, sale of assets or otherwise.

  
 1.25 “Term” shall have the meaning set
forth in Section 10.1. 
  
 1.26 “Third
Maximum” shall have the meaning set forth in Section 4.2(b)(iii). 
  
 1.27 “Third Party” shall mean any entity other than SMRI or ACADIA or an Affiliate of SMRI or ACADIA. 
  
 2. DEVELOPMENT PROGRAM.  
  
 2.1 Development Program. During the Development Term, ACADIA shall use commercially reasonable efforts to conduct the Development Program in
accordance with the Development Plan and the terms of this Agreement. The initial Development Plan will be completed by ACADIA and presented to the DAC within thirty (30) days of the Effective Date. 
  
 2.2 Amendments to the Development Plan. ACADIA may amend the
Development Plan from time to time in its sole discretion. Prior to finalizing any such amendment to the Development Plan which [...***...] 
  

			
	*** Certain confidential information on this page has been omitted and filed separately with the Commission. Confidential treatment has been requested with respect to the omitted
portions.

  

 3. 

 [...***...] or [...***...], ACADIA shall provide the proposed amendment to the members of the DAC and SMRI,
and the DAC and SMRI shall have [...***...] days to review and provide ACADIA comments on such proposed amendment. ACADIA shall consider any such input in good faith when finalizing such amendment and shall distribute the finalized amendment
to the DAC and SMRI. In the event that SMRI reasonably believes that the finalized amendment will [...***...], SMRI may notify the DAC and ACADIA in writing of such belief, which notice shall include the basis for such belief in reasonable
detail, provided that such notice is given within [...***...] days of receipt of the final amendment. [...***...] Within [...***...] days after such notice from SMRI (or such longer period as agreed by ACADIA and SMRI), each member
of the DAC shall provide notice in writing to ACADIA of whether it approves the final amendment as proposed, or not. If [...***...] approve the amendment as proposed, [...***...]. If [...***...] do not approve the amendment as
proposed [...***...]. 
  
 3. GOVERNANCE.

  
 3.1 Development Advisory Committee. Promptly
after the Effective Date, the parties will form a Development Advisory Committee comprised of [...***...] of ACADIA, who shall initially be [...***...], [...***...] of SMRI, who shall initially be [...***...], and
[...***...] mutually agreed upon by ACADIA and SMRI, [...***...] shall initially be [...***...] One (1) member of the DAC shall be selected to act as the chairperson of the DAC, with each chairperson acting for a term of twelve
(12) months. The chairperson shall be selected by ACADIA. The DAC shall review the data and activities of the Development Program and monitor the progress of development in relation to the Development Plan. The DAC shall meet on a semi-annual basis
or at such other frequency as the DAC agrees. The parties shall agree upon the time and place of meetings. A reasonable number of additional representatives of a party may attend meetings of the DAC. ACADIA shall reimburse the member of the DAC
appointed by SMRI for all reasonable costs and expenses (including travel and lodging expenses) incurred thereby in participating as a member of the DAC. 
  
 3.2 Information and Reports. Except as otherwise provided in this Agreement, ACADIA will make available and disclose to SMRI and each member
of the DAC all results of the work conducted pursuant to the Development Plan prior to and in preparation for DAC meetings. 
  
 4. FEES AND PAYMENTS. 
  
 4.1 Funding. 
  
 (a) Upon the Effective Date, SMRI shall make a loan to ACADIA of $1,000,000 in support of the Development Program pursuant to the terms set forth
in the 
  

			
	*** Certain confidential information on this page has been omitted and filed separately with the Commission. Confidential treatment has been requested with respect to the omitted
portions.

  

 4. 

 convertible promissory note attached hereto as Exhibit A (the “Note”). In connection with
the Note, SMRI makes the representations and warranties set forth on Exhibit B hereto. 
  
 (b) Subject to the terms and conditions set forth herein, SMRI shall pay to ACADIA the following amounts in cash by the following dates in support of the Development Program: 
  

			
	Date	 	Amount
	 [...***...]
	 	$1,000,000
	 [...***...]
	 	$1,000,000
	 [...***...]
	 	$1,000,000
	 [...***...]
	 	$1,000,000
	 [...***...]
	 	$1,000,000

  
 (c) All amounts
paid to ACADIA by SMRI under this Section 4.1 shall be spent on the Development Program. 
  
 4.2 Royalty Payments. 
  
 (a) Royalty Payments by ACADIA. Subject to ACADIA having received the $1,000,000 payment due under Section 4.1(b) by [...***...] and subject to Section 4.2(b), ACADIA shall pay to SMRI during the Royalty Term, a royalty
of (A) [...***...] percent ([...***...]%) of annual Net Sales of ACADIA Products by ACADIA and its Affiliates, and (B) [...***...] percent ([...***...]%) of royalty payments received by ACADIA from Licensees on sales of
ACADIA Products.  
  
 (b) Maximum Royalty Payment
Amount. 
  
 (i) In the event that ACADIA makes total
payments to SMRI under this Section 4.2 of at least [...***...] ([...***...]%) of the total amount SMRI has paid to ACADIA under Section 4.1(b) (the “First Maximum”) prior to the [...***...] anniversary of
the Effective Date, ACADIA’s obligation to make payments to SMRI pursuant to this Section 4.2 shall terminate. At any time within six (6) months prior to the [...***...] anniversary of the Effective Date, ACADIA may make a lump sum cash
payment to SMRI equaling the amount by which the First Maximum exceeds the total amount already paid to SMRI under this Section 4.2, and upon receipt of such payment by SMRI, ACADIA’s obligation to make payments to SMRI pursuant to this Section
4.2 shall terminate. 
  
 (ii) In the event that ACADIA
makes total payments to SMRI under this Section 4.2 of at least [...***...] ([...***...]%) of the total amount SMRI has paid to ACADIA under Section 4.1(b) (the “Second Maximum”) prior to the [...***...]
anniversary of the Effective Date, ACADIA’s obligation to make payments to SMRI pursuant to this Section 4.2 shall terminate. At any time after the [...***...] anniversary of the Effective Date and prior to the [...***...]
anniversary of the Effective Date, ACADIA shall be entitled to make a lump sum cash payment to SMRI equaling the amount by which the Second Maximum exceeds the total amount already paid to SMRI under this Section 4.2, and upon 
  

			
	*** Certain confidential information on this page has been omitted and filed separately with the Commission. Confidential treatment has been requested with respect to the omitted
portions.

  

 5. 

 receipt of such payment by SMRI, ACADIA’s obligation to make payments to SMRI pursuant to this Section 4.2 shall
terminate. 
  
 (iii) In the event that ACADIA makes total
payments to SMRI under this Section 4.2 of at least [...***...] ([...***...]%) of the total amount SMRI has paid to ACADIA under Section 4.1(b) (the “Third Maximum”) prior to the [...***...] anniversary of
the Effective Date, ACADIA’s obligation to make payments to SMRI pursuant to this Section 4.2 shall terminate. At any time after the [...***...] anniversary of the Effective Date and prior to the [...***...] anniversary of the
Effective Date, ACADIA shall be entitled to make a lump sum cash payment to SMRI equaling the amount by which the Third Maximum exceeds the total amount already paid to SMRI under this Section 4.2, and upon receipt of such payment by SMRI,
ACADIA’s obligation to make payments to SMRI pursuant to this Section 4.2 shall terminate. 
  
 5. PAYMENTS; RECORDS; AUDITS. 
  
 5.1 Payment; Reports. Royalty payments due under Section 4.2 and reports for the sale of ACADIA Products by ACADIA and its Affiliates and
royalty payments received by ACADIA from Licensees on sales of ACADIA Products shall be calculated and reported for each calendar quarter. All royalty payments due to SMRI under Section 4.2 shall be paid within sixty (60) days of the end of each
calendar quarter. Each payment of royalties shall be accompanied by a report of Net Sales of ACADIA Products in sufficient detail to permit confirmation of the accuracy of the royalty payment made, including, without limitation, the number of each
ACADIA Product sold by ACADIA and its Affiliates, the gross sales and Net Sales of such ACADIA Products sold by ACADIA and its Affiliates in U.S. dollars, the exchange rates used, the royalty payments received by ACADIA from Licensees on the sale of
ACADIA Products, and any other information necessary to determine the appropriate amount of royalties due under Section 4.2. ACADIA will keep complete and accurate records pertaining to such calculation to permit SMRI to confirm the accuracy of
royalty payments due hereunder. ACADIA shall pay SMRI interest at the Applicable Rate on any payments pursuant to Section 4.2(a) that are not timely paid by ACADIA to SMRI. 
  
 5.2 Exchange Rate; Manner and Place of Payment. All payments hereunder shall be payable in U.S. dollars. With
respect to each quarter, for countries other than the United States, whenever conversion of payments from any foreign currency shall be required, such conversion shall be made at an exchange rate equal to the weighted average of the rates of
exchange for the currency of the country from which payments are payable as published by The Wall Street Journal, Western U.S. Edition, during the calendar quarter for which a payment is due. All payments owed under this Agreement shall be
made by wire transfer to a bank and account designated in writing by the payee, unless otherwise specified by such payee. 
  
 5.3 Records and Audits. On thirty (30) days’ prior written notice, SMRI shall have the right to have an independent certified public
accountant, inspect the books and records of ACADIA and/or its Affiliates and/or its Licensees, no more than once per fiscal year during usual business hours for the sole purpose of and only to the extent necessary to verify the completeness and
accuracy of the records and payments made under this Agreement. Such examination with respect to any fiscal year shall not take place later than two (2) years following the end of such fiscal year. The accountant shall inform SMRI only if there has
been an 
  

			
	*** Certain confidential information on this page has been omitted and filed separately with the Commission. Confidential treatment has been requested with respect to the omitted
portions.

  

 6. 

 underpayment or an overpayment or misappropriation of payments, and if so, the amount thereof. The expense of any such
inspection shall be borne by SMRI; provided, however, that, if the inspection discloses an underpayment in excess of ten percent (10%) then ACADIA shall pay the out of pocket costs of such audit. 
  
 5.4 Withholding of Taxes. Any withholding of taxes levied by
tax authorities outside the United States on the payments hereunder shall be borne by the party receiving such payment and deducted by the party making such payment from the sums otherwise payable by it hereunder for payment to the proper tax
authorities. The parties agree to cooperate with each other, in the event a party claims exemption from such withholding or seeks deductions under any double taxation or other similar treaty or agreement from time to time in force, such cooperation
to consist of providing receipts of payment of such withheld tax or other documents reasonably available. 
  
 5.5 Exchange and Royalty Rate Controls. If at any time legal restrictions prevent the prompt remittance of part or all royalties with
respect to any country where any ACADIA Product is sold, payment shall be made through such lawful means or methods as ACADIA may determine. When in any country the law or regulations prohibit both the transmittal and deposit of royalties on sales
in such a country, royalty payments shall be suspended for as long as such prohibition is in effect, and as soon as such prohibition ceases to be in effect, all royalties that would have been obligated to be transmitted or deposited, but for the
prohibition, shall forthwith be deposited or transmitted promptly to the extent allowable, as the case may be. If any royalty rate specified in this Agreement should exceed the permissible rate established in any country, the royalty rate for sales
in such country shall be adjusted to the highest legally permissible or government-approved rate. 
  
 6. INTELLECTUAL PROPERTY RIGHTS. 
  
 6.1 Intellectual Property. 
  
 (a) SMRI hereby acknowledges that, as between the parties, other than as provided for herein, ACADIA owns all patent and/or other intellectual
property rights in the Compound, ACADIA Product, any inventions or developments developed by or on behalf of ACADIA or any its employees, consultants, Affiliates, sublicensees or collaborators in connection with the activities contemplated by this
Agreement (including, without limitation, the Inventions and Proprietary Rights), test results, and any other deliverables provided hereunder, and all derivatives and improvements thereof. For avoidance of doubt, except as expressly provided in this
Section 6, nothing in this Agreement is intended or shall be deemed to grant to SMRI any ownership or rights in or to the Compound, ACADIA Product, any inventions or developments developed by or on behalf of ACADIA or any its employees, consultants,
Affiliates, sublicensees or collaborators in connection with the activities contemplated by this Agreement (including, without limitation, the Inventions and Proprietary Rights), test results, or any other deliverables provided hereunder, or any
derivatives and improvements thereof, or any patent and/or other intellectual property rights in the foregoing. 
  
 (b) ACADIA shall notify SMRI promptly in writing of all inventions or discoveries which meet all of the following criteria: (i) reduced to practice
by ACADIA; (ii) directly or indirectly resulting from research that is funded, in whole or in part, by SMRI 
  

 7. 

 subject to the terms and conditions of this Agreement; (iii) not related to the Compound or ACADIA Product or its
manufacture or use; and (iv) owned or licensable by ACADIA (hereafter referred to as “Inventions”), and all patents, patent applications, copyrights, trademarks, trade secrets, know-how and other intellectual property rights
related thereto, owned or licensable by ACADIA (hereafter referred to as “Proprietary Rights”). ACADIA shall promptly provide SMRI with a detailed written description of any Inventions or Proprietary Rights, and any other
reasonably requested information pertaining thereto. 
  
 (c)
Title to any Invention and Proprietary Rights shall be determined according to applicable law. Subject to the terms and conditions of this Agreement, including, without limitation, Section 8, ACADIA hereby grants to SMRI a perpetual,
royalty-free, non-exclusive, non-sublicensable, non-transferable, world-wide license to make, use, execute, reproduce, display, perform and create derivative works based upon any Invention or Proprietary Rights disclosed to SMRI in accordance with
Section 6.1(b) above solely for SMRI’s own internal, non-profit, non-commercial research uses, consistent with the charitable purposes of SMRI, without any further payment obligations or liability to ACADIA. ACADIA shall take all appropriate
steps, including obtaining any necessary assignments from individual inventors (whether any principal investigator(s) or others), to ensure that ACADIA has all necessary rights to grant to SMRI the rights set forth in this Section 6.1(c).

  
 6.2 License to SMRI. 
  
 (a) If ACADIA has decided to terminate all efforts to develop and
commercialize the ACADIA Product in the United States for any reason other than scientific reasons, including termination of (i) its own research, development and/or commercialization activities, (ii) the research, development and/or
commercialization activities of any Affiliate, licensee or transferee and (iii) its efforts to identify any licensee or transferee of rights to the ACADIA Product in the United States, ACADIA shall promptly notify SMRI in writing of such pending
termination. If SMRI notifies ACADIA in writing within sixty (60) days after the date of such notice from ACADIA that it is interested in obtaining rights to develop and commercialize the ACADIA Product in the United States and has the resources,
itself or together with a Third Party, to diligently develop and commercialize the ACADIA Product in the United States, then ACADIA and SMRI will negotiate in good faith for a period of sixty (60) days (or such longer period as agreed in writing by
the parties) the grant to SMRI of an exclusive license (with the right to grant sublicenses), under those patent rights or other intellectual property rights owned or licensed (with the right to further sublicense) by ACADIA as of such time, which
are necessary to develop, make, use, sell, offer for sale or import the ACADIA Product in the United States, to develop, make, use, sell, offer for sale and import the ACADIA Product in the United States (the “License
Grant”). 
  
 (b) If the parties do enter into
an agreement providing for the License Grant following good faith negotiation pursuant to Section 6.2(a), then, to the extent the following items are within ACADIA’s control and can be provided without breach of any obligation to or agreement
with any Third Party, ACADIA shall provide SMRI with copies of all preclinical and clinical data and study results, INDs (investigational new drug application(s) filed with the Food and Drug Administration pursuant to Part 312 of Title 21 of the
U.S. Code of Federal Regulations, including any amendments thereto) and other regulatory filings, studies, information and materials relating to the development and commercialization of the ACADIA 
  

 8. 

 Product generated by or on behalf of ACADIA (including pharmacology, toxicology, formulation, and stability studies).

  
 (c) If SMRI does not provide notice of its interest to
ACADIA within the initial sixty (60) day period under Section 6.2(a), or if SMRI does provide such notice within such period, but the parties do not enter into an agreement providing for the License Grant within the negotiation period specified in
Section 6.2(a), then ACADIA shall have no further obligations, and SMRI shall have no further rights under this Section 6.2. 
  
 6.3 Patent Abandonment. Prior to ACADIA abandoning any patent or patent application owned by ACADIA that is related to the Compound and/or
any Invention or Proprietary Right (including abandonment for failure to pay any required fees), other than in the ordinary course of patent prosecution, ACADIA shall promptly notify SMRI in writing of such pending abandonment, whereupon SMRI shall
have the right and opportunity, upon written notice to ACADIA provided within thirty (30) days after such notice from ACADIA, to take title to the applicable patent and/or patent application and to maintain the issued patent or continue the
prosecution of the patent application at SMRI’s own expense; provided, however, that, at such time as when SMRI first exercises its rights under this Section 6.3 with respect to any patent or patent application, upon the request
of ACADIA, SMRI shall grant to ACADIA (a) a non-exclusive, irrevocable, royalty-free, non-sublicensable and non-transferable (except as permitted by Section 12.7) right to use such patent and/or patent application for ACADIA’s own, internal,
non-commercial uses, or (b) subject to SMRI’s right to use the patent and/or patent application (and/or any invention(s) claimed in such patent and/or patent application) for its own internal research purposes, the first right to negotiate with
SMRI, in good faith, the terms of an exclusive license to develop and commercialize any invention(s) claimed in such patent and/or patent application; provided, further, that if SMRI and ACADIA do not enter into a written agreement
within ninety (90) days following SMRI’s notice of taking title to the patent and/or patent application, SMRI shall be free to negotiate with, and license the rights to develop and commercialize any invention(s) claimed in such patent and/or
patent application to, one or more Third Parties. 
  
 6.4
Third Party Development. So long as the royalty payment obligations of ACADIA have not been terminated in accordance with Section 4.2(b), if ACADIA enters into any agreement with a Third Party granting such Third Party rights to develop
or commercialize the Compound or ACADIA Product, ACADIA shall use its best efforts to ensure that such agreement provides that, in the event that such Third Party decides to terminate or abandon all efforts to develop and commercialize the ACADIA
Product in the United States, all rights to intellectual property of ACADIA, which are necessary to develop, make, use, sell, offer for sale or import the ACADIA Product in the United States, that are licensed to such Third Party by ACADIA under
such agreement will revert to ACADIA so that ACADIA may comply with the provisions of Sections 6.1, 6.2 and 6.3 with respect to such intellectual property rights to the extent Sections 6.1, 6.2 and 6.3 apply. ACADIA will notify SMRI in the event
that it enters into any such agreement with a Third Party granting such Third Party rights to develop or commercialize the Compound or ACADIA Product. 
  

 9. 

 7. REPRESENTATIONS AND WARRANTIES. 
  
 7.1 Representations and Warranties. Each party represents to
the other that as of the Effective Date: 
  
 (a)
Corporate Power. It is duly organized and validly existing under the laws of its state of incorporation or formation, and has full power (corporate or otherwise) and authority to enter into this Agreement and to carry out the provisions
hereof; 
  
 (b) Due Authorization. It is duly
authorized to execute and deliver this Agreement and to perform its obligations hereunder, and the person or persons executing this Agreement on its behalf has been duly authorized to do so by all requisite action (corporate or otherwise); and

  
 (c) Binding Agreement. This Agreement is legally
binding upon it and enforceable in accordance with its terms. The execution, delivery and performance of this Agreement by it does not conflict with any agreement, instrument or understanding, oral or written, to which it is a party or by which it
may be bound, nor violate any material law or regulation of any court, governmental body or administrative or other agency having jurisdiction over it. 
  
 7.2 Disclaimers. 
  
 (a) Except as specifically set forth in this Agreement, NEITHER PARTY MAKES ANY REPRESENTATIONS AND WARRANTIES OF ANY KIND, EITHER EXPRESS OR
IMPLIED. 
  
 (b) ACADIA EXPRESSLY DISCLAIMS ANY WARRANTY,
EXPRESS OR IMPLIED, WITH RESPECT TO (i) THE SUCCESS OF THE DEVELOPMENT PROGRAM AND (ii) THE SAFETY, USEFULNESS OR SUCCESSFUL COMMERCIALIZATION OF THE COMPOUND OR ANY ACADIA PRODUCT. 
  
 8. CONFIDENTIALITY; PUBLICATION. 
  
 8.1 Confidentiality. Except to the extent expressly authorized by this Agreement or otherwise agreed in
writing by the parties, the parties agree that, during the Term and for the five (5) year period immediately following the Term, each party (the “Receiving Party”) shall keep confidential and shall not publish or otherwise
disclose and shall not use for any purpose (other than as expressly provided for in this Agreement) any Confidential Information furnished to it by, or otherwise belonging to, the other party (the “Disclosing Party”) pursuant
to this Agreement. Each party may use Confidential Information of the other party only to the extent required to accomplish the purposes of this Agreement. The Receiving Party will use at least the same standard of care as it uses to protect
proprietary or confidential information of its own to ensure that its employees, agents, consultants and other representatives do not disclose or make any unauthorized use of such proprietary or confidential information. Each party will promptly
notify the other upon discovery of any unauthorized use or disclosure of the other party’s Confidential Information. 
  

 10. 

 8.2 Exceptions. The obligations of confidentiality and non-use contained in Section 8.1
will not apply to the extent it can be established by the Receiving Party by competent written proof that such Confidential Information: 
  
 (a) is now, or hereafter becomes, through no act or failure to act on the part of the Receiving Party, generally known or available; 
  
 (b) is known by the Receiving Party at the time of receiving such
information, other than under confidentiality, as evidenced by its records; 
  
 (c) is hereafter furnished to the Receiving Party by a Third Party, as a matter of right and without restriction on disclosure; 
  
 (d) is independently developed by the Receiving Party without the aid, application or use of Confidential Information
of the Disclosing Party; or 
  
 (e) is the subject of a
written permission to disclose provided by the Disclosing Party. 
  
 8.3 Terms of Agreement. The parties agree that this Agreement and the terms hereof will be considered Confidential Information of both parties. Notwithstanding the foregoing, either party may disclose such terms as are
required to be disclosed under strictures of confidentiality for fund raising or financing efforts to investors and lenders and potential investors and lenders or as otherwise required pursuant to applicable law, and with respect to ACADIA, to bona
fide potential licensees. 
  
 8.4 Authorized Disclosure.
Each party may disclose Confidential Information belonging to the other party to the extent such disclosure is reasonably necessary in the following instances: 
  
 (a) regulatory filings; 
  
 (b) prosecuting or defending litigation; 
  
 (c) complying with applicable court orders or governmental regulations; and 
  
 (d) disclosure to Affiliates, licensees, employees, consultants, agents or other Third Parties in connection with due
diligence or similar investigations by such Third Parties, in each case who agree to be bound by similar terms of confidentiality and non-use at least equivalent in scope to those set forth in this Section 8. 
  
 Notwithstanding the foregoing, in the event a party is required to make a
disclosure of the other party’s Confidential Information pursuant to this Section 8.4, it will seek to secure confidential treatment of such information at least as diligently as such party would use to protect its own Confidential Information.
The parties will consult with each other on the provisions of this Agreement to be redacted in any filings made by the parties with the Securities and Exchange Commission or as otherwise required by law. 
  

 11. 

 8.5 Publications. SMRI may publish a summary of work performed by ACADIA under the
Development Program in SMRI’s annual reports and on SMRI’s website; provided, however, that ACADIA shall have until the earlier of such time as ACADIA or its designee publishes the results of such work and eighteen (18) months after
completion of such work to file patents before SMRI may publish a summary of such work. In no event will SMRI disclose or use any Confidential Information of ACADIA in such publication without ACADIA’s prior written consent, which may not be
unreasonably withheld; provided, however, that ACADIA acknowledges that, in order to preserve its tax-exempt status, SMRI must be able to publish a summary of work performed under the Development Program, and ACADIA will work in good faith
with SMRI to reach agreement upon the summary of such work to be published by SMRI and will not unreasonably withhold its consent to the inclusion of Confidential Information of ACADIA contained in such summary. ACADIA shall be free to publish
papers regarding the Development Program without the prior written consent of SMRI and shall use commercially reasonable efforts to publicize SMRI’s monetary contribution to the Development Program in any such papers. 
  
 9. INDEMNIFICATION. 
  
 9.1 Indemnification. ACADIA shall indemnify, defend and hold
harmless SMRI, its Affiliates and their respective directors, officers, employees and agents (including, without limitation, the SMRI Development Advisory Committee representative) (each, an “Indemnitee”), from and against
any and all Third Party claims, suits, demands, liabilities, damages, losses, costs, penalties, fines and expenses (including court costs and the reasonable fees of attorneys and other professionals) to the extent arising out of or resulting from:

  
 (a) ACADIA’s breach of any of its representations,
warranties, covenants and/or obligations under this Agreement; 
  
 (b) The negligence or willful misconduct of ACADIA or its Affiliates and/or their respective directors, officers, employees, agents or representatives (or any of them), in connection with ACADIA’s performance of its obligations
under this Agreement; and/or 
  
 (c) Any tort claims of
personal injury (including death) relating to or arising out of any such injury sustained as the result of, or in connection with, the Development Program; 
  
 except that such indemnification obligation under this Section 9.1 shall not apply to the extent such Third Party claims, suits, demands, liabilities, damages, losses,
costs, penalties, fines and expenses are proven to arise out of or result from the negligence or willful misconduct of any Indemnitee or the breach by SMRI of any of its representations, warranties, covenants and/or obligations under this Agreement.

  
 9.2 Procedures for Indemnification. Promptly
after receipt by an Indemnitee of notice of the commencement of any action, suit or proceeding, such Indemnitee shall, if a claim for indemnification in respect thereof is to be made against ACADIA, deliver to ACADIA written notice of the
commencement thereof, and ACADIA shall have the right to assume and manage the defense thereof (with counsel reasonably satisfactory to ACADIA and such Indemnitee), including the right to settle, compromise and/or litigate with respect to any such

  

 12. 

 claim (but only after obtaining SMRI’s prior written consent with respect to any proposed settlement, compromise or
litigation); provided, however, that ACADIA shall not be required to obtain SMRI’s prior written consent in connection with any proposed settlement, compromise or litigation if, in connection with and following any such
settlement, compromise or litigation, SMRI has (a) no liability (monetary or otherwise), (b) not waived any of its rights and (c) not admitted to any wrongdoing or guilt. 
  
 9.3 Advance Payment of Expenses; Complete Indemnification. The expenses of an Indemnitee incurred in defending
a civil or criminal action, suit or proceeding shall be paid by ACADIA as they are incurred and in advance of the final disposition of the action, suit or proceeding, upon receipt of an undertaking by or on behalf of the Indemnitee to repay the
amount if it is ultimately determined by a court of competent jurisdiction that such Indemnitee is not entitled to be indemnified by ACADIA. All costs and expenses incurred by an Indemnitee in connection with enforcement of Section 9.1 also shall be
reimbursed by ACADIA. 
  
 9.4 Insurance. ACADIA will
maintain at its own expense, with a reputable insurance carrier, product liability insurance and comprehensive general liability insurance in an amount consistent with industry standards during the term of this Agreement and will name SMRI as an
additional insured with respect to such insurance. ACADIA will provide SMRI with a certificate of insurance evidencing such coverage. 
  
 10. TERM AND TERMINATION. 
  
 10.1 Term of the Agreement. The term of this Agreement (the “Term”) shall commence on the Effective Date and
continue until the expiration of the Royalty Term, unless earlier terminated pursuant to Section 10.2, 10.3, 10.4 or 10.5 or extended by mutual written agreement of the parties. 
  
 10.2 Termination by Mutual Agreement. The parties may at any time terminate this Agreement by written
agreement executed by both SMRI and ACADIA. 
  
 10.3
Termination by ACADIA. ACADIA may terminate this Agreement with thirty (30) days’ prior written notice to SMRI in the event that ACADIA (a) enters into a Strategic Alliance or (b) transfers or sells all or substantially all of the
business of ACADIA to which this Agreement relates to an Affiliate or Third Party, whether by merger, sale of stock, sale of assets or otherwise. 
  
 10.4 Termination by SMRI. 
  
 (a) SMRI may terminate this Agreement with thirty (30) days’ prior written notice to ACADIA in the event that SMRI: (i) disagrees with
[...***...] proposed by ACADIA and not approved by [...***...]; or (ii) in good faith, based on information provided by the DAC believes that reasonable progress on the Development Program is not occurring in accordance with the
Development Plan. Prior to any termination under this Section 10.4(a), SMRI agrees to meet with the DAC and ACADIA to discuss potential improvements to the Development Program and/or Development Plan in an attempt to prevent SMRI’s termination
of this Agreement pursuant to this Section 10.4(a). 
  

			
	*** Certain confidential information on this page has been omitted and filed separately with the Commission. Confidential treatment has been requested with respect to the omitted
portions.

  

 13. 

 (b) SMRI may terminate this Agreement with thirty (30) days’ prior written notice in the
event that ACADIA: (i) abandons the Development Program; or (ii) decides to enter into a Strategic Alliance; provided, however, that SMRI shall have the right to apply future payments due under Section 4.1 to other schizophrenia related
research being conducted by ACADIA as mutually agreed to by the parties in lieu of terminating this Agreement under this Section 10.4(b). 
  
 10.5 Termination for Cause. Each party shall have the right to terminate this Agreement upon sixty (60) days’ prior written notice to
the other upon the occurrence of any of the following: 
  
 (a)
Upon or after the bankruptcy, insolvency, dissolution or winding up of the other party (other than a dissolution or winding up for the purpose of reconstruction or amalgamation); or 
  
 (b) Upon or after the breach of any material provision of this Agreement by the other party if the breaching party
has not cured such breach within the sixty (60) day period following written notice of termination by the non-breaching party. 
  
 10.6 Effect of Termination or Expiration; Surviving Obligations. Expiration or termination of this Agreement shall not affect any rights or
obligations of either party accruing prior to such expiration or termination. Upon expiration or termination of this Agreement, all rights and obligations of the parties under this Agreement shall terminate, except that (a) the terms of Sections 1,
5.3, 6.1, 7, 8, 9.1, 9.2, 9.3, 10.6, 11 and 12 of this Agreement shall survive any expiration or termination of this Agreement and (b) if this Agreement is terminated by ACADIA under Section 10.3 or by SMRI under Section 10.4 or 10.5 after ACADIA
has received the $1,000,000 payment due on [...***...], the terms of Section 4.2, 5, 6.2, 6.3, 6.4 and 9.4 shall survive such termination until the expiration of the Royalty Term. Promptly after expiration or termination of this Agreement,
except as otherwise provided in this Section 10.6, each party shall return or dispose of any Confidential Information of the other party in the accordance with the instructions of such other party. 
  
 11. GOVERNING LAW; DISPUTE RESOLUTION. 
  
 11.1 Governing Law. This Agreement shall be governed by the
laws of the State of Delaware as such laws are applied to contracts entered into or to be performed entirely within such state. 
  
 11.2 Dispute Resolution. Except with respect to matters pertaining to injunctive relief, in the event of any dispute, the parties shall
refer such dispute to the Chief Executive Officer of ACADIA and the Executive Director of SMRI for attempted resolution by good faith negotiations within sixty (60) days after such referral is made. During such period of good faith negotiations, any
applicable time periods under this Agreement shall be tolled. In the event such executives are unable to resolve such dispute within such sixty (60) day period, the parties shall submit their dispute to binding arbitration before a retired Maryland
Circuit Court Judge at J.A.M.S./Endispute located in Montgomery County, Maryland, such arbitration to be conducted pursuant to the J.A.M.S./Endispute procedure rules for commercial disputes then in 
  

			
	*** Certain confidential information on this page has been omitted and filed separately with the Commission. Confidential treatment has been requested with respect to the omitted
portions.

  

 14. 

 effect. The award of the arbitrator shall include an award of reasonable attorneys’ fees and costs to the prevailing
party. 
  
 11.3 Jurisdiction and Venue. Except as
provided in Section 11.2 above, any claim or controversy arising out of or related to this Agreement or any breach hereof (including claims for injunctive relief) shall be adjudicated in the state and federal courts in Montgomery County having
jurisdiction over disputes arising in the State of Maryland, and the parties hereby consent to the jurisdiction and venue of such courts. 
  
 12. General Provisions. 
  
 12.1 Notices. All notices required or permitted to be given under this Agreement shall be in writing and shall be mailed by registered or
certified mail, Federal Express or other nationally recognized overnight delivery service, addressed to the signatory to whom such notice is required or permitted to be given and transmitted by facsimile to the number indicated below. All notices
shall be deemed to have been given when mailed, as evidenced by the postmark at the point of mailing, or faxed. 
  

			
	All notices to SMRI shall be addressed as follows:	 	Stanley Medical Research Institute 5430 Grosvenor Lane, Suite 200 Bethesda, MD 20814 Attn: Dr. Michael Knable, DO Fax: (301) 571-0769
		
	 with a copy to:
	 	 Fleischman and Walsh, L.L.P.
 1919 Pennsylvania
Avenue, N.W
 Suite 600
 Washington, DC 20006
 Attn: Sean P. McGuinness
 Fax: (202) 265-5706

		
	All notices to ACADIA shall be addressed as follows:	 	 ACADIA Pharmaceuticals Inc.
 3911 Sorrento Valley
Blvd.
 San Diego, CA 92121
 Attn: Vice President, Business
Development
 Fax: (858) 558-2872

		
	 with a copy to:
	 	 Cooley Godward LLP
 4401 Eastgate Mall
 San Diego, CA 92121
 Attn: L. Kay Chandler
 Fax: (858) 550-6420

  
 Any party may, by
written notice to the other, designate a new address or fax number to which notices to the party giving the notice shall thereafter be mailed or faxed. 
  
 12.2 Force Majeure. No party shall be liable for any delay or failure of performance (other than payment obligations) to the extent such
delay or failure is caused by 
  

 15. 

 circumstances beyond its reasonable control and that by the exercise of due diligence it is unable to prevent, provided
that the party claiming excuse uses its commercially reasonable efforts to overcome the same. 
  
 12.3 Entirety of Agreement. This Agreement (and the exhibits attached hereto) embodies the entire, final and complete agreement and understanding between the parties and replaces and supersedes all prior
discussions and agreements between them with respect to its subject matter. No modification or waiver of any terms or conditions hereof shall be effective unless made in writing and signed by a duly authorized officer of each party. 
  
 12.4 Non-Waiver. The failure of a party in any one or more
instances to insist upon strict performance of any of the terms and conditions of this Agreement shall not constitute a waiver or relinquishment, to any extent, of the right to assert or rely upon any such terms or conditions on any future occasion.

  
 12.5 Disclaimer of Agency or Partnership.
Neither party is, or will be deemed to be, the legal representative or agent of the other, nor shall either party have the right or authority to assume, create, or incur any third party liability or obligation of any kind, express or implied,
against or in the name of or on behalf of another except as expressly set forth in this Agreement. In addition, neither party shall be deemed to be a member of a partnership with the other party, nor shall SMRI be deemed to be a “Sponsor”
(as defined by the Food and Drug Administration) of any clinical trial for an ACADIA Product. 
  
 12.6 Severability. If a court of competent jurisdiction declares any provision of this Agreement invalid or unenforceable, or if any government or other agency having jurisdiction over either ACADIA or
SMRI deems any provision to be contrary to any laws, then that provision shall be severed and the remainder of the Agreement shall continue in full force and effect. To the extent possible, the parties shall revise such invalidated provision in a
manner that will render such provision valid without impairing the parties’ original intent. 
  
 12.7 Assignment. Except as expressly provided hereunder, neither this Agreement nor any rights or obligations hereunder may be assigned or
otherwise transferred by either party without the prior written consent of the other party (which consent shall not be unreasonably withheld); provided, however, that ACADIA may assign this Agreement and its rights and obligations hereunder
without SMRI’s consent in connection with the transfer or sale of all or substantially all of the business of such party to which this Agreement relates to an Affiliate or Third Party, whether by merger, sale of stock, sale of assets or
otherwise; provided further that SMRI may assign its right to receive payments under this Agreement to a taxable wholly owned subsidiary of SMRI without ACADIA’s consent. The rights and obligations of the parties under this Agreement
shall be binding upon and inure to the benefit of the successors and permitted assigns of the parties. Any assignment not in accordance with this Agreement shall be void. 
  
 12.8 Headings. The headings contained in this Agreement are inserted for reference only and shall not be
deemed a part of the text hereof. 
  
 12.9 Limitation of
Liability. EXCEPT FOR AMOUNTS PAYABLE UNDER SECTION 4 AND LIABILITY FOR BREACH OF CONFIDENTIALITY, NO 
  

 16. 

 PARTY SHALL BE LIABLE TO ANOTHER FOR INDIRECT, INCIDENTAL, CONSEQUENTIAL, SPECIAL OR EXEMPLARY DAMAGES, INCLUDING BUT NOT
LIMITED TO LOST PROFITS, ARISING FROM OR RELATING TO ANY BREACH OF THIS AGREEMENT, REGARDLESS OF ANY NOTICE OF THE POSSIBILITY OF SUCH DAMAGES. 
  
 12.10 Counterparts. This Agreement may be executed in one or more counterparts, each of which shall be an original and all of which shall
constitute together the same document. 
  
 12.11 Public
Disclosure. Except for such disclosure as is deemed necessary, in the reasonable judgment of a party, to comply with applicable laws or regulations, no public announcement, news release, public statement or publication relating to the existence
of this Agreement, or the terms hereof, will be made without the other party’s prior written approval, which approval shall not be unreasonably withheld. The parties agree that they will use reasonable efforts to coordinate the initial
announcement or press release relating to the existence of this Agreement so that such initial announcement or press release is made within forty-five (45) days of the Effective Date. 
  
 12.12 Expenses. Each party shall pay all costs and expenses that it incurs with respect to the negotiation,
execution, delivery and performance of this Agreement; provided, however, that ACADIA shall reimburse the reasonable fees of and expenses of counsel for SMRI in connection with the negotiation, execution and delivery of this Agreement, not to
exceed in the aggregate, [...***...] dollars [...***...] without the prior written consent of ACADIA. 
  
 [Remainder of this page intentionally left blank.] 
  

			
	*** Certain confidential information on this page has been omitted and filed separately with the Commission. Confidential treatment has been requested with respect to the omitted
portions.

  
  

 17. 

 IN WITNESS WHEREOF, the parties hereto have duly executed this DEVELOPMENT AGREEMENT.

  

			
	ACADIA PHARMACEUTICALS INC.
		
	By:	 	/s/    Uli Hacksell        
	 	 	

		
	Title:	 	CEO
	 	 	

  

			
	THE STANLEY MEDICAL RESEARCH INSTITUTE
		
	By:	 	/s/    Michael B. Knable         
	 	 	

		
	Title:	 	Executive Director
	 	 	

  
  
 [SIGNATURE PAGE TO DEVELOPMENT AGREEMENT] 

 EXHIBIT A 
  

CONVERTIBLE PROMISSORY NOTE 
  
 THIS CONVERTIBLE PROMISSORY NOTE HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED. NO SALE OR DISPOSITION MAY BE EFFECTED EXCEPT IN COMPLIANCE WITH
RULE 144 UNDER SAID ACT OR AN EFFECTIVE REGISTRATION STATEMENT RELATED THERETO OR AN OPINION OF COUNSEL FOR HOLDER REASONABLY SATISFACTORY TO PAYOR THAT SUCH REGISTRATION IS NOT REQUIRED UNDER THE ACT OR RECEIPT OF A NO-ACTION LETTER FROM THE
SECURITIES AND EXCHANGE COMMISSION. 
  
 CONVERTIBLE
PROMISSORY NOTE 
  
 $1,000,000
                                        
                                        
                                        
                                        
        May 3, 2004 
  
 For value received ACADIA PHARMACEUTICALS INC., a Delaware corporation (“Payor”), promises to pay to THE STANLEY MEDICAL
RESEARCH INSTITUTE or its assigns (“Holder”) the principal sum of $1,000,000, together with interest on the outstanding balance hereof at the rate of nine percent (9%) per
annum, compounded annually. Interest shall commence with the date hereof and shall continue on the outstanding principal until paid in full or converted. Interest shall be computed on the basis of a year of 365 days for the actual number of days
elapsed. 
  
 1. This note (this
“Note”) is issued pursuant to the terms of that certain Development Agreement between Holder and Payor (the “Agreement”), dated as of May 3, 2004 (the “Agreement Date”).

  
 2. All payments of interest and principal shall be in
lawful money of the United States of America and shall be made to Holder. All payments shall be applied first to accrued interest, and thereafter to principal. 
  
 3. In the event that Payor issues and sells shares of its common stock, $0.0001 par value per share (the
“Common Stock”), before November 3, 2005 (the “Maturity Date”) in a firm commitment underwritten public offering registered pursuant to the Security Act of 1933, as amended (the “Initial
Public Offering”), then the outstanding principal balance of this Note, together with interest hereon through the date of such Initial Public Offering, shall automatically convert in whole without any further action by Holder into
shares of Payor’s Common Stock effective upon the closing of the Initial Public Offering at a conversion price equal to the price per share to the public of a share of Payor’s Common Stock in the Initial Public Offering. In the event that
Payor issues and sells shares of its Equity Securities to investors (the “Investors”) (i) after the Agreement Date but (ii) before the Maturity Date or the closing of the Initial Public Offering, in a private financing
(including the conversion of this Note) with gross offering proceeds of not less than $10,000,000 (a “Private Financing”), then the outstanding principal balance of this Note, together with interest hereon through the date of
the initial closing of the Private Financing, shall, at Payor’s election, convert in whole without any further action by Holder into such Equity Securities at a conversion price equal to the price per share paid by the investors on the same
terms and conditions as given to the Investors. For purposes of this Note, the term “Equity Securities” shall mean shares of Payor’s preferred stock or any securities conferring the right to purchase Payor’s
preferred stock or securities convertible into, or exchangeable for (with or without additional consideration), Payor’s preferred stock. 

 4. Unless this Note has been converted in accordance with the terms of Section 3 above, the entire
outstanding principal balance and all unpaid accrued interest shall become fully due and payable on the Maturity Date. 
  
 5. If there is an Event of Default (as defined below), Payor shall pay all reasonable attorneys’ fees and court costs incurred by Holder in
enforcing and collecting this Note. 
  
 6. Payor may prepay
this Note, in whole or in part and at any time, or from time to time, prior to the Maturity Date without the consent of Holder. 
  
 7. If there shall be any Event of Default hereunder, upon the declaration of Holder, this Note shall accelerate and all principal and unpaid
accrued interest shall become due and payable. From and after the occurrence of an Event of Default, this Note shall bear interest at the rate of fifteen percent (15%) per annum, compounded annually. The occurrence of any one or more of the
following shall constitute an Event of Default: 
  
 (a)
Payor fails to pay any amount when due hereunder; 
  
 (b)
Payor files any petition or action for relief under any bankruptcy, reorganization, insolvency or moratorium law or any other law for the relief of, or relating to, debtors, now or hereafter in effect, or makes any assignment for the benefit of
creditors or takes any corporate action in furtherance of any of the foregoing; or 
  
 (c) An involuntary petition is filed against Payor (unless such petition is dismissed or discharged within sixty (60) days, under any bankruptcy statute now or hereafter in effect, or a custodian, receiver,
trustee, assignee for the benefit of creditors (or other similar official) is appointed to take possession, custody or control of any property of Payor. 
  
 8. Payor hereby waives demand, notice, presentment, protest and notice of dishonor. 
  
 9. This Note shall be governed by construed and under the laws of the
State of Delaware, as applied to agreements among Delaware residents, made and to be performed entirely within the State of Delaware, without giving effect to conflicts of laws principles. 
  
 10. The indebtedness evidenced by this Note is subordinated in right
of payment to the prior payment in full of any Senior Indebtedness in existence on the date of this Note. “Senior Indebtedness” shall mean, unless expressly subordinated to or made on a parity with the amounts due under this
Note, all amounts due in connection with (a) indebtedness of Payor to banks, equipment lessors or other financial institutions and (b) any such indebtedness or any debentures, notes or other evidence of indebtedness issued in exchange for such
Senior Indebtedness, or any indebtedness arising from the satisfaction of such Senior Indebtedness by a guarantor. 
  
 11. Any term of this Note may be amended or waived with the written consent of Payor and Holder. 

			
	ACADIA PHARMACEUTICALS INC.
		
	By:	 	/s/ Uli Hacksell
	 	 	

	 	 	 Name: Uli Hacksell
 Title: Chief Executive Officer

  
  
  

 EXHIBIT B 
  

SMRI 
  
 REPRESENTATIONS AND WARRANTIES 
  
 1. Purchase for Own Account. SMRI represents that it is acquiring the Promissory Note, any securities issuable upon conversion of the Note and any securities issuable upon conversion of those securities
(collectively, the “Securities”) (i) solely for its own account and beneficial interest for investment and not for re-sale or with a view to distribution of the Securities or any part thereof, (ii) has no present intention of
selling (in connection with a distribution or otherwise), granting any participation in, or otherwise distributing the same, and (iii) does not presently have reason to anticipate a change in such intention. 
  
 2. Investment Experience and Qualified Institutional Buyer/Accredited Investor
Status. SMRI either (i) is a qualified institutional buyer as defined in Rule 144A promulgated under the Securities Act of 1933, as amended (the “Securities Act”), or (ii) is a large institution that is an
“accredited investor” within the meaning of such term under paragraph (a)(1), (a)(2), (a)(3) or (a)(7) of Rule 501 promulgated under the Securities Act. SMRI is an investor in securities of companies in the development stage and
acknowledges that it is able to protect its own interests, and bear the economic risk of its investment and has such knowledge and experience in financial or business matters that it is capable of evaluating the merits and risks of the investment in
the Securities hereunder. SMRI believes it has received all the information it considers necessary or appropriate for deciding whether to purchase the Securities. 
  
 3. Restricted Securities. SMRI understands that the Securities are, or when issued, will be, restricted securities under the
federal securities laws inasmuch as they are being acquired from ACADIA in a transaction not involving a public offering and that under such laws and applicable regulations such securities may be resold without registration under the Securities Act
only in certain limited circumstances. In this connection, SMRI represents that it is familiar with Rule 144 promulgated under the Securities Act, as presently in effect, and understands the resale limitations imposed thereby and by the Securities
Act. 
  
 4. Further Limitations on Disposition. Without in any way
limiting the representations set forth above, SMRI further represents, warrants and agrees that it will not make any disposition of all or any portion of the Securities unless: 
  
 (a) There is then in effect a registration statement under the Securities Act (a “Registration
Statement”), covering such proposed disposition and such disposition is made in accordance with such Registration Statement; or 
  
 (b) The disposition is made pursuant to Rule 144 or similar provisions of federal securities laws as in effect from time to time; or 
  
 (c) (i) SMRI shall have notified ACADIA of the proposed disposition;
and (ii) if requested by ACADIA, SMRI shall have furnished ACADIA with an opinion of counsel, reasonably satisfactory to ACADIA, that such disposition will not require registration of such Securities under the Securities Act. 

 5. Restrictive Legend. SMRI understands and agrees that all certificates evidencing the Securities may bear
the following legends: 
  
 (a) THE SECURITIES REPRESENTED
HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), AND MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED, ASSIGNED, PLEDGED OR HYPOTHECATED UNLESS (A) PURSUANT TO RULE 144 OR RULE 144A UNDER THE ACT
OR (B) THERE IS AN EFFECTIVE REGISTRATION STATEMENT UNDER THE ACT COVERING SUCH SECURITIES OR (C) THE COMPANY RECEIVES AN OPINION OF COUNSEL FOR THE HOLDER OF THESE SECURITIES REASONABLY SATISFACTORY TO THE COMPANY AND ITS COUNSEL STATING THAT SUCH
SALE, TRANSFER, ASSIGNMENT, PLEDGE OR HYPOTHECATION IS EXEMPT FROM THE REGISTRATION AND PROSPECTUS DELIVERY REQUIREMENTS OF THE ACT; and 
  
 (b) any other appropriate legends. 
  
 6. “Stand-Off” Agreement. SMRI if requested by ACADIA and the managing underwriter of an offering by ACADIA of Common Stock or other securities of
ACADIA pursuant to a Registration Statement, shall agree not to sell publicly or otherwise transfer or dispose of the Securities or any securities of ACADIA held by SMRI for a specified period of time (not to exceed 180 days) following the effective
date of such Registration Statement.Employment Agreement between Redback Networks, Inc. and Kevin A. Denuccio

  Exhibit 10.1
 REDBACK NETWORKS INC. 
      250 Holger Way
 San Jose, CA 95134 
  August 17, 2001   Mr. Kevin A.
DeNuccio  

 Dear Kevin: 
  Redback Networks Inc. (the “Company”) is pleased to offer you employment on the following terms:

  1.   Position. Your title will be President and Chief Executive Officer (“PCEO”), and you will report to the Company’s Board of Directors (the “Board”). You
will also be elected as a member of the Board. By signing this letter agreement, you confirm to the Company that you have no contractual commitments or other legal obligations that would prohibit you from performing your duties for the
Company. 
  2.   Salary. The Company will pay you a salary at the rate of $500,000 per year, payable in accordance with the Company’s standard payroll schedule. This salary
will be subject to review by the Compensation Committee of the Board pursuant to the Company’s executive compensation policies in effect from time to time, but it will not be reduced without your consent. 
  3.   Annual Incentive Bonus. You will be eligible to be considered for an incentive bonus for each fiscal year of the Company. The bonus (if any) for years after 2001 will be awarded based on objective or
subjective criteria established by the Compensation Committee of the Board. Your target bonus will be equal to 100% of your annual base salary. Your bonus for the year 2001 will be equal to a pro rata portion of $500,000. The pro rata portion will
be a fraction, the numerator of which is the number of calendar days you are employed by the Company in 2001 and the denominator of which is 365. The bonus for a fiscal year will be paid after the Company’s books for that year have been closed
and will be paid only if you arc employed by the Company at the time of payment (except as provided below). The determinations of the Compensation Committee of the Board with respect to your bonus will be final and binding. 
  4.   Signing Bonus. The Company will pay you a signing bonus of $3,000,000 within five business days after the commencement of your employment. If, before you complete 12 months of continuous
employment with the Company and before a “Change in Control” (as defined in the Company’s 1999 Stock Incentive Plan), your employment ends because you resign without Good Reason or due to a termination by the Company for Cause

	  
	
[RETURN TO TABLE OF CONTENTS]  	 
	 
 

  Mr. Kevin A. DeNuccio
 8/17/01
 Page 2
 (each referred to hereafter as a
“Pay-back Event”), then you must return a pro rata portion of the signing bonus (on an after-tax basis) to the Company. The pro rata portion will be equal to one minus a fraction, the numerator of which is the number of calendar days you
have been employed by the Company and the denominator of which is 365 (hereafter referred to as the “Pro Rata Return Portion”). For purposes of calculating the after-tax amount of the Pro Rata Return Portion under this Paragraph 4, a 50%
marginal tax rate shall be utilized. 
  “Cause” means (a) an unauthorized use or disclosure of the Company’s confidential information or trade secrets, which use or disclosure
causes material harm to the Company, (b) an intentional and material breach of any agreement between you and the Company which causes material harm to the Company, (c) an intentional and material failure to comply with the Company’s written
policies or rules which causes material harm to the Company, (d) conviction of, or plea of “guilty” or “no contest” to, a felony under the laws of the United States or any state thereof, (e) gross negligence or willful
misconduct, or (f) an intentional and continued failure to perform assigned duties after receiving written notification of such failure from the Board and the failure to remedy such repeated failure within sixty days of such notice. For these
purposes, no act or failure to act shall be considered “intentional” unless it is done, or omitted to be done, in bad faith without reasonable belief that the action or omission was in the best interest of the Company. The foregoing,
however, is not an exclusive list of all acts or omissions that the Company may consider as grounds for discharging you without Cause. 
  5.   Employee Benefits. As an executive of
the Company, you will be eligible to participate in a number of Company-sponsored benefits. In addition, you will be entitled to paid vacation in accordance with the Company’s vacation policy, as in effect from time to time. You will also be
indemnified to the fullest extent permitted by applicable law and be covered under the Company’s directors and officers insurance policy for errors and omissions. 
  6.   Stock
Options. You will be granted an option to purchase 6,500,000 shares of the Company’s Common Stock. The exercise price per share will be equal to the fair market value per share on the date of this letter or the fair market value per share
on your first day of employment, whichever is less. The option will be subject to the terms and conditions applicable to options granted under the Company’s 1999 Stock Incentive Plan (the “Plan”), as described in the Plan and the
applicable Stock Option Agreement, except as otherwise provided in this letter agreement. 
  The option will be immediately exercisable with respect to 1,625,000 shares, but the Pro Rata Return
Portion of the 1,625,000 shares will be subject to repurchase by the Company at the exercise price if, before you complete 12 months of continuous employment with the Company, your employment ends due to the occurrence of a Pay-back Event. If the
Company is subject to a Change in Control before your employment with the Company terminates, the Company’s right to repurchase any shares will lapse in full. 

	     
	
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  Mr. Kevin A. DeNuccio
 8/17/01
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 The option will become exercisable
with respect to the remaining 4,875,000 shares in equal monthly installments over your first 36 months of continuous employment with the Company. If you are subject to an Involuntary Termination, then the exercisable portion of the remaining
4,875,000 shares will be determined by adding 12 months to the actual period of employment that you have completed with the Company. If the Company is subject to a Change in Control before your employment with the Company terminates, then your stock
option will immediately be fully vested and exercisable with respect to all shares. 
  “Involuntary Termination” means either (a) involuntary discharge by the Company for reasons
other than Cause or (b) voluntary resignation by you for Good Reason where Good Reason is either (i) a change in your position with the Company that reduces your level of authority or responsibility, (ii) you are no longer PCEO of the Company or its
parent entity (if any), (iii) a reduction in your base salary or target bonus, other than a reduction that applies pro rata to all members of the Company’s senior management team, or (iv) receipt of notice that your principal workplace
will be relocated more than 30 miles. 
  In addition, if your employment terminates for any reason other than a Pay-back Event, then your entire option will remain exercisable for a period of 12
months following the date of your termination of employment. 
  7.   Restricted Shares. You will be granted 500,000 shares of the Company’s Common Stock. The shares will
be subject to the terms and conditions applicable to restricted shares granted under the Plan, as described in the Plan and the applicable Restricted Stock Agreement. The Pro Rata Return Portion of the 500,000 shares will revert to the Company if,
before you complete 12 months of continuous employment with the Company, your employment ends due to a Pay-back Event. If the Company is subject to a Change in Control before your employment with the Company terminates, then all of your restricted
shares will immediately vest in full. 
  8.   Severance Pay. If you are subject to an Involuntary Termination, the Company will pay you a lump sum equal to the sum of (a) your base
salary for a period of 12 months plus (b) your target bonus for the year in which the Involuntary Termination occurs. Your base salary will be based on the rate in effect at the time of the termination of your employment. If you elect to continue
your health insurance coverage under the Consolidated Omnibus Budget Reconciliation Act (“COBRA”) following the Involuntary Termination, then the Company will pay your monthly premium under COBRA until the earliest of (a) the close of the
12-month period following the Involuntary Termination, (b) the expiration of your continuation coverage under COBRA or (c) the date when you receive substantially equivalent health insurance coverage in connection with new employment or
self-employment. However, this Paragraph 8 will not apply unless (a) before any Change in Control you and the Company sign a general mutual release of claims (in a form prescribed by the Company) of all known and unknown claims that the Company may
then have against you or you may then have against the 

	     
	
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  Mr. Kevin DeNuccio
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 Page 4
 Company or persons affiliated with the Company excepting for claims to
indemnification or under the directors and officers insurance coverage and (b) you have returned all Company property. 
  9. Golden Parachute Payments. 
  (a)   Gross-Up Payment. If it is determined that any payment or distribution of any type to you or for your benefit by the Company, any of its affiliates, any person who acquires ownership or effective control
of the Company or ownership of a substantial portion of the Company’s assets (within the meaning of section 280G of the Internal Revenue Code of 1986, as amended (the “Code”), and the regulations thereunder) or any affiliate of such
person, whether paid or payable or distributed or distributable pursuant to the terms of this letter agreement or otherwise (the "Total Payments"), would be subject to the excise tax imposed by section 4999 of the Code or any interest or
penalties with respect to such excise tax (such excise tax and any such interest or penalties are collectively referred to as the “Excise Tax”), then you will be entitled to receive an additional payment (a “Gross-Up Payment”) in
an amount calculated to ensure that after you pay all taxes (and any interest or penalties imposed with respect to such taxes), including any Excise Tax, imposed upon the Gross-Up Payment, you retain an amount of the Gross-Up Payment equal to the
Excise Tax imposed upon the Total Payments. 
  (b)    Determination by Accountant. All determinations and calculations required to be made under this Paragraph 9 will be made
by an independent accounting firm selected by you from among the largest five accounting firms in the United States (the “Accounting Firm”). The Accounting Firm will provide its determination (the “Determination”), together with
detailed supporting calculations regarding the amount of any Gross-Up Payment and any other relevant matter, to you and the Company within five business days after you or the Company made a request (if you reasonably believe that any of the Total
Payments may be subject to the Excise Tax). If the Accounting Firm determines that no Excise Tax is payable by you, it will furnish you with a written statement that it has concluded that no Excise Tax is payable (including the reasons therefor) and
that you have substantial authority not to report any Excise Tax on your federal income tax return. If a Gross-Up Payment is determined to be payable, it will be paid to you within five business days after the Determination has been delivered to you
or the Company. Any determination by the Accounting Firm will be binding upon the Company and you, absent manifest error. 
  (c)   Over- and Underpayments. As a result of
uncertainty in the application of section 4999 of the Code at the time of the initial determination by the Accounting Firm hereunder, it is possible that Gross-Up Payments not made by the Company should have been made (“Underpayment”), or
that Gross-Up Payments will have been made by the Company that should not have been made (“Overpayment”). In either event, the Accounting Firm will determine the amount of the Underpayment or Overpayment that has occurred. In the case of
an 

	     
	
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 Underpayment, the amount of such
Underpayment will promptly be paid by the Company to you or for your benefit. In the case of an Overpayment, you will, at the direction and expense of the Company, take such steps as are reasonably necessary (including the filing of returns and
claims for refund), follow reasonable instructions from, and procedures established by, the Company, and otherwise reasonably cooperate with the Company to correct such Overpayment, provided, however, that (i) you will in no event be obligated to
return to the Company an amount greater than the net after-tax portion of the Overpayment that you have retained or have recovered as a refund from the applicable taxing authorities and (ii) this provision will be interpreted in a manner consistent
with the intent of Subparagraph (a) above, which is to make you whole, on an after-tax basis, from the application of the Excise Tax, it being understood that the correction of an Overpayment may result in your repaying to the Company an amount that
is less than the Overpayment. 
  (d)   Limitation on Golden Parachute Payments. Any other provision of this Paragraph 9 notwithstanding, if the Excise Tax could be avoided by
reducing the Total Payments by $100,000 or less, then the Total Payments will be reduced to the extent necessary to avoid the Excise Tax and no Gross-Up Payment will be made. If the Accounting Firm determines that the Total Payments are to be
reduced under the preceding sentence, then the Company will promptly give you notice to that effect and a copy of the detailed calculation thereof. You may then elect, in your sole discretion, which and how much of the Total Payments are to be
eliminated or reduced (as long as after such election no Excise Tax will be payable), and you will advise the Company in writing of your election within five business days of receipt of notice. If you make no such election within such five-day
period, then the Company may elect which and how much of the Total Payments are to be eliminated or reduced (as long as after such election no Excise Tax will be payable), and it will notify you promptly of such election. 
  10.   Proprietary Information and Inventions Agreement. Like all Company employees, you will be required, as a condition of your employment with the Company, to sign the Company’s standard
Proprietary Information and Inventions Agreement, a copy of which is attached hereto as Exhibit A. 
  11.   Employment Relationship. Employment with the Company is for no
specific period of time. Your employment with the Company will be “at will,” meaning that either you or the Company may terminate your employment at any time and for any reason, with or without cause. Any contrary representations that may
have been made to you are superseded by this offer. This is the full and complete agreement between you and the Company on this term. Although your job duties, title, compensation and benefits, as well as the Company’s personnel policies and
procedures, may change from time to time, the “at will” nature of your employment may only be changed in an express written agreement signed by you and the Board or the Board’s designee. 

	  
	
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 Page 6
 12.   Outside
Activities. While you render services to the Company, you agree that you will not engage in any other employment, consulting or other business activity without the prior written consent of the Company. Promptly after executing this letter
agreement, you will resign from the boards of directors of Callisma, Inc., Netpliance, Inc. and Broad River. The Company acknowledges that you will remain a member of the board of directors of Salesnet. While you render services to the Company, you
will not assist any person or entity in competing with the Company, in preparing to compete with the Company or in hiring any employees or consultants of the Company. 
  13.
  Withholding Taxes. All forms of compensation referred to in this letter agreement are subject to reduction to reflect applicable required withholding and payroll taxes and other deductions required by law. 
  14.   Nomination of Directors Subject to the approval of the Board or its Nominating Committee, you will be entitled to nominate two candidates for election as members of the Board. 

 15.   Professional Fees. The Company will pay for all reasonable professional fees that are incurred in connection with the negotiation of the terms of your employment and for the
preparation, review and interpretation of this letter agreement, but the amount paid will not exceed $10,000. 
  16.   Entire Agreement. This letter agreement supersedes and
replaces any prior agreements, representations or understandings, whether written, oral or implied, between you and the Company. 
  17.   Arbitration. You and the Company
agree to waive any rights to a trial before a judge or jury and agree to arbitrate before a neutral arbitrator any and all claims or disputes arising out of this letter agreement and any and all claims arising from or relating to your employment
with the Company, including (but not limited to) claims against any current or former employee, director or agent of the Company, claims of wrongful termination, retaliation, discrimination, harassment, breach of contract, breach of the covenant of
good faith and fair dealing, defamation, invasion of privacy, fraud, misrepresentation, constructive discharge or failure to provide a leave of absence, or claims regarding commissions, stock options or bonuses, infliction of emotional distress or
unfair business practices. 
  The arbitrator’s decision must be written and must include the findings of fact and law that support the decision. The arbitrator’s decision will be final and
binding on both parties, except to the extent applicable law allows for judicial review of arbitration awards. The arbitrator may award any remedies that would otherwise be available to the parties if they were to bring the dispute in
court. The arbitration will be conducted in accordance with the National Rules for the Resolution of Employment Disputes of the American Arbitration Association; 

	   
	
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 provided, however that the
arbitrator must allow the discovery authorized by the California Arbitration Act or the discovery that the arbitrator deems necessary for the parties to vindicate their respective claims or defenses. The arbitration will take place in Santa Clara
County or, at your option, the county in which you primarily worked with the Company at the time when the arbitrable dispute or claim first arose. 
  You and the Company will share the costs of
arbitration equally, except that the Company will bear the cost of the arbitrator’s fee and any other type of expense or cost that you would not be required to bear if you were to bring the dispute or claim in court. Both the Company and you
will be responsible for their own attorneys’ fees, and the arbitrator may not award attorneys’ fees unless a statute or contract at issue specifically authorizes such an award. 
  This
arbitration provision does not apply to (a) workers’ compensation or unemployment insurance claims or (b) claims concerning the validity, infringement or enforceability of any trade secret, patent right, copyright or any other trade secret or
intellectual property held or sought by either you or the Company (whether or not arising under the Proprietary Information and Inventions Agreement between you and the Company) or (c) claims for indemnification or under the directors and officers
insurance policy. 
  If an arbitrator or court of competent jurisdiction (the “Neutral”) determines that any provision of this arbitration provision is illegal or unenforceable, then the
Neutral shall modify or replace the language of this arbitration provision with a valid and enforceable provision, but only to the minimum extent necessary to render this arbitration provision legal and enforceable. 
  *****  We hope that you will accept our offer to join the Company. You may indicate your agreement with these terms and accept this offer by signing and dating
both the enclosed duplicate original of this letter agreement and the enclosed Proprietary Information and Inventions Agreement and returning them to me. As required by law, your employment with the Company is contingent upon your providing
legal proof of your identity and authorization to work in the United States. Your employment is also contingent upon your starting work with the Company on or before August 29, 2001. This offer letter is
subject to approval by the Board of Directors, to be obtained on or before August 29, 2001.

	     
	
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	 	 	Very truly yours, 
	 	 	 
	 	 	REDBACK NETWORKS INC.  
	 	 	 
	 	 	By: /s/ Pierre R.
Lamond                                  
	 	 	      Chairman of the Board of Directors 
	 	 	 
	 	 	 
	I have read and accept this employment offer:	 	 
	 	 	 
	/s/ Kevin A. DeNuccio	 	 
	 
 	 	 
	Signature of Kevin A. DeNuccio	 	 
	 	 	 
	Attachment	 	 
	Exhibit A: Proprietary Information and Inventions Agreement 	 	 

  

	  
	
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 Amendment #1 
 This is Amendment #1 to the Letter Agreement between Kevin DeNuccio,
(“Employee”) and Redback Networks Inc., (“Redback”) with a principal place of business of 250 Holger Way, San Jose, CA 95134 dated August 17, 2001 (“Agreement”). 
 WHEREAS, the parties have entered into an Agreement under which Redback has agreed to grant Stock Options under its 1999 Stock Incentive Plan (the “Plan”); and
 WHEREAS, the parties now desire to grant such options under a S-8 registration;
 THEREFORE the parties agree as follows:

	 	 	 
	 	1.  	In Section 6 of the Agreement, the third sentence of the first paragraph shall be deleted in its entirety and replaced as follows: 
	 	 	 
	 	 	 
	 	 	“Except as otherwise provided in this letter agreement, the option will be granted under a stock option agreement that has terms substantially similar to options
granted under Stock Option Agreements applicable to the Company’s 1999 Stock Incentive Plan (the “Plan”). The options will not be granted under the Plan but will be registered in an S-8 which will be filed within 60 days of the date
of this letter agreement.” 
	 	 	 
	 	2.	Except as expressly stated in this Amendment the Agreement shall continue in full force and effect.
	 	 	 
	 	 	 
	 	 AGREED AND ACCEPTED
 	 AGREED AND ACCEPTED 
 
			 	 
	 	 	  	 REDBACK NETWORKS, INC.  
 
	 	 	 
	 	 	 
	 	 ____________________________
 Kevin A. DeNuccio
 	 ___________________________
 Thomas L. Cronan, III
 Vice President and General Counsel

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