Document:

Exhibit 4.2

 

EXECUTION VERSION

 

 

EXACT SCIENCES CORPORATION

 

0.3750% Convertible Senior Notes due 2028

 

 

 

THIRD SUPPLEMENTAL INDENTURE

 

Dated as of February 27, 2020

 

to

 

INDENTURE

 

Dated as of January 17, 2018

 

 

 

U.S. BANK NATIONAL ASSOCIATION,

as Trustee

 

 

    

     

    

 

TABLE
OF CONTENTS

 

Page

 

	Article
    1 Scope of Third Supplemental Indenture; Definitions	1
	Section
    1.01.   Scope of Third Supplemental Indenture	1
	Section
    1.02.   Definitions	2
	Article
    2 The Notes	11
	Section
    2.01.   Designation, Amount and Issuance of Notes	11
	Section
    2.02.   Form of the Notes	12
	Section
    2.03.   Date and Denomination of Notes; Payment at Maturity; Payment of Interest	12
	Section
    2.04.   Exchange of Global Notes	13
	Section
    2.05.   Outstanding Notes	15
	Section
    2.06.   Defaulted Interest	15
	Section
    2.07.   Ranking	16
	Article
    3 Repurchase of Notes	16
	Section
    3.01.   Repurchase at Option of Holders Upon a Fundamental Change	16
	Section
    3.02.   Withdrawal of Fundamental Change Repurchase Notice	20
	Section
    3.03.   Deposit of Fundamental Change Repurchase Price	20
	Section
    3.04.   Notes Repurchased in Part	20
	Section
    3.05.   Covenant to Comply with Securities Laws Upon Repurchase of Notes	20
	Article
    4 Covenants	21
	Section
    4.01.   Payment of Notes	21
	Section
    4.02.   Maintenance of Office or Agency	21
	Section
    4.03.   Reports	22
	Section
    4.04.   Compliance Certificate	22
	Section
    4.05.   Statement by Officer as to Default	22
	Section
    4.06.   Waiver of Stay, Extension or Usury Laws	22
	Article
    5 Successor Company	23
	Section
    5.01.   When Company May Merge or Transfer Assets	23
	Section
    5.02.   Successor to Be Substituted	23
	Section
    5.03.   Opinion of Counsel to Be Given Trustee	24
	Article
    6 Defaults and Remedies	24
	Section
    6.01.   Events of Default	24
	Section
    6.02.   Acceleration	26

 

    - i  -

     

    

 

	Section
    6.03.   Other Remedies	27
	Section
    6.04.   Waiver of Past Defaults	27
	Section
    6.05.   Control by Majority	27
	Section
    6.06.   Limitation on Suits	28
	Section
    6.07.   Rights of Holders to Receive Payment	28
	Section
    6.08.   Collection Suit by Trustee	28
	Section
    6.09.   Trustee May File Proofs of Claim	29
	Section
    6.10.   Priorities	29
	Section
    6.11.   Undertaking for Costs	30
	Section
    6.12.   Failure to Comply with Reporting Covenant	30
	Article
    7 [RESERVED]	31
	Article
    8 Discharge of Indenture	31
	Section
    8.01.   Discharge of Liability on Notes	31
	Section
    8.02.   Application of Trust Money	31
	Section
    8.03.   Repayment to Company	31
	Section
    8.04.   Reinstatement	32
	Article
    9 Amendments	32
	Section
    9.01.   Without Consent of Holders	32
	Section
    9.02.   With Consent of Holders	33
	Section
    9.03.   Revocation and Effect of Consents and Waivers	34
	Section
    9.04.   Notation on or Exchange of Notes	35
	Section
    9.05.   Trustee to Sign Amendments	35
	Article
    10 Conversion of Notes	35
	Section
    10.01.   Right to Convert	35
	Section
    10.02.   Conversion Procedures; Settlement Upon Conversion; No Adjustment for Interest or Dividends;
    Cash Payments in Lieu of Fractional Shares	38
	Section
    10.03.   Adjustment to Conversion Rate Upon a Make-Whole Fundamental Change	42
	Section
    10.04.   Adjustment of Conversion Rate	44
	Section
    10.05.   Effect of Reclassifications, Business Combinations, Asset Sales and Corporate Events	53
	Section
    10.06.   Certain Covenants	55
	Section
    10.07.   [Reserved]	55
	Section
    10.08.   Stockholder Rights Plans	55
	Section
    10.09.   Responsibility of Trustee	55
	Article
    11 Miscellaneous	56
	Section
    11.01.   Notices	56
	Section
    11.02.   No Optional Redemption	56

 

    ii 

     

    

 

	Section
    11.03.   When Notes Disregarded	56
	Section
    11.04.   Withholding Taxes	56
	Section
    11.05.   GOVERNING LAW	56
	Section
    11.06.   Counterparts	56
	Section
    11.07.   Table of Contents; Headings	57
	Section
    11.08.   Calculations	57
	Section
    11.09.   Legal Holidays	57

 

Exhibit A     -     Form of Note

 

    iii 

     

    

 

THIRD SUPPLEMENTAL INDENTURE dated as of February
27, 2020 between EXACT SCIENCES CORPORATION, a Delaware corporation, as issuer (the “Company”), and U.S. BANK
NATIONAL ASSOCIATION, a national banking association organized under the laws of the United States, as trustee (the “Trustee”).

 

WHEREAS, the Company has executed and delivered
to the Trustee an Indenture dated as of January 17, 2018 (the “Base Indenture” and, as supplemented by this
Third Supplemental Indenture (the “Third Supplemental Indenture”), the “Indenture”) providing
for the issuance from time to time of one or more series of the Company’s debt securities;

 

WHEREAS, Section 3.1 of the Base Indenture
provides that the Company and the Trustee may enter into an indenture supplemental to the Base Indenture to establish the form
or terms of Securities of any series;

 

WHEREAS, the Company has duly authorized the
creation of an issue of its 0.3750% Convertible Senior Notes due 2028 (the “Notes”), having the terms, tenor,
amount and other provisions hereinafter set forth, and, to provide therefor, the Company has duly authorized the execution and
delivery of this Third Supplemental Indenture; and

 

WHEREAS, all things necessary to make the
Notes, when the Notes are duly executed by the Company and authenticated and delivered hereunder and duly issued by the Company,
the valid obligations of the Company, and to make this Third Supplemental Indenture a valid and binding agreement of the Company,
in accordance with their and its terms, have been done and performed, and the execution of this Third Supplemental Indenture and
the issue hereunder of the Notes have in all respects been duly authorized,

 

NOW, THEREFORE, THIS THIRD SUPPLEMENTAL INDENTURE
WITNESSETH:

 

For and in consideration of the premises and
the purchase of the Notes by the holders thereof, it is mutually covenanted and agreed, for the equal and proportionate benefit
of all holders of the Notes, as follows:

 

Article
1

Scope of Third Supplemental Indenture; Definitions

 

Section
1.01.        Scope
of Third Supplemental Indenture. This Third Supplemental Indenture supplements the provisions of the Base Indenture, to
which provisions reference is hereby made. The changes, modifications and supplements to the Base Indenture effected by this
Third Supplemental Indenture shall be applicable only with respect to, and shall only govern the terms of, the Notes, which
may be issued from time to time, and shall not apply to any other Securities that may be issued under the Base Indenture
unless a supplemental indenture with respect to such other Securities specifically incorporates such changes, modifications
and supplements. Unless the context otherwise requires, section references are to this Third Supplemental Indenture rather
than the Base Indenture. For all purposes under the Base Indenture, the Notes shall constitute a single series of Securities.
The provisions of this Third Supplemental Indenture shall supersede any conflicting provisions in the Base Indenture with
respect to the Notes.

 

    

     

    

 

Section
1.02.        Definitions.
Each term used herein which is defined in the Base Indenture has the meaning assigned to such term in the Base Indenture unless
otherwise specifically defined herein, in which case the definition set forth herein shall govern for purposes of the Notes. The
words “herein”, “hereof”, “hereunder” and words of similar import refer
to the Indenture as a whole and not to any particular Article, Section or other subdivision. The word “or” is
not exclusive and the word “including” means including without limitation. The terms defined in this Article
include the plural as well as the singular.

 

“1% Exception” has the
meaning specified in Section 10.04(i).

 

“Additional Interest” means
all amounts, if any, payable pursuant to Section 6.12.

 

“Additional Notes” has
the meaning specified in Section 2.01.

 

“Additional Shares” has
the meaning specified in Section 10.03.

 

“Affiliate” of any specified
Person means any other Person, directly or indirectly, controlling or controlled by or under direct or indirect common control
with such specified Person. For the purposes of this definition, “control” when used with respect to any Person means
the power to direct the management and policies of such Person, directly or indirectly, whether through the ownership of voting
securities, by contract or otherwise; and the terms “controlling” and “controlled” have meanings correlative
to the foregoing. Notwithstanding anything to the contrary herein, the determination of whether one Person is an “Affiliate”
of another Person for purposes of the Indenture shall be made based on the facts at the time such determination is made or required
to be made, as the case may be, hereunder.

 

“Agent Members” has the
meaning specified in Section 2.04(f).

 

“announcement date” shall
mean, with respect to a distribution by the Company to all or substantially all of its holders of Common Stock, the date of announcement
for such distribution.

 

“Averaging Period” has
the meaning specified in Section 10.04(e).

 

“Bankruptcy Law” has the
meaning specified in Section 6.01.

 

“Bid Solicitation Agent”
means the Person appointed by the Company to solicit bids for the Trading Price of the Notes in accordance with Section 10.01(b)(4).
The Company shall initially act as the Bid Solicitation Agent. The Company may appoint a replacement Bid Solicitation Agent (including
any of the Company’s Affiliates) without prior notice to the Holders (but will provide notice thereof to the Trustee).

 

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“Business Day” means any
day other than a Saturday, a Sunday or a day on which the Federal Reserve Bank of New York is authorized or required by law or
executive order to close or be closed.

 

“Capital Stock” of any
Person means any and all shares, interests, rights to purchase, warrants, options, participations or other equivalents of or interests
in (however designated) equity of such Person, including any Preferred Stock, but excluding any debt securities convertible into
such equity.

 

“Cash Settlement” has the
meaning set forth in Section 10.02(b).

 

“Close of Business” means
5:00 p.m., New York City time.

 

“Closing Sale Price” per
share of the Common Stock or any other security for which a Closing Sale Price must be determined on any Trading Date means:

 

(1)       the
closing sale price per share of the Common Stock or such other security (or if no closing sale price is reported, the average of
the closing bid and closing ask prices or, if more than one in either case, the average of the average closing bid and the average
closing ask prices) on such Trading Day as reported in composite transactions for the Relevant Stock Exchange;

 

(2)       if
the Common Stock or such other security is not listed on a Relevant Stock Exchange on such date, the last quoted bid price per
share for the Common Stock or such other security in the over-the-counter market on such Trading Day as reported by OTC Markets
Group Inc. or a similar organization; or

 

(3)       if
the Common Stock or such other security is not so quoted, the average of the mid-point of the closing bid and closing ask price
per share for the Common Stock on such Trading Day as determined by a nationally recognized securities dealer retained by the Company
for that purpose, which may include any of the Underwriters.

 

The Closing Sale Price shall be determined
without reference to early hours, after hours or extended market trading.

 

“Combination Settlement”
has the meaning set forth in Section 10.02(b).

 

“Common Stock” means the
common stock, par value $0.01 per share, of the Company, or such other capital stock into which the Company’s common stock
is reclassified or changed pursuant to Section 10.05.

 

“Company” means the party
named as such in the Indenture until a successor replaces it and, thereafter, means the successor.

 

“Conversion Agent” means
the Person appointed by the Company to which Notes may be presented for conversion. The Conversion Agent appointed by the Company
shall initially be the Trustee.

 

    - 3 -

     

    

 

“Conversion Date” has the
meaning specified in Section 10.02(a).

 

“Conversion Notice” has
the meaning specified in Section 10.02(a).

 

“Conversion Obligation”
has the meaning specified in Section 10.01(a).

 

“Conversion Price” on
any date of determination means $1,000 divided by the Conversion Rate as of such date.

 

“Conversion Rate” shall
initially be 8.2076 shares of Common Stock per $1,000 principal amount of Notes, subject to adjustment as provided in Article 10.

 

“Corporate Trust Office”
or other similar term, means the designated office of the Trustee at which at any particular time its corporate trust business
as it relates to the Indenture shall be administered, which office is, at the date as of which the Indenture is dated, located
at 214 N. Tryon Street, 27th Floor, Charlotte, NC 28202 Attention: Exact Sciences Corporation Administrator or at any other time
at such other address as the Trustee may designate from time to time by notice to the Company.

 

“Custodian” has the meaning
specified in Section 6.01.

 

“Daily Conversion Value”
means, for each of the 30 consecutive VWAP Trading Days during the applicable Observation Period, 1/30th of the product of:

 

(1)       the
Conversion Rate in effect on that VWAP Trading Day, and

 

(2)       the
Daily VWAP of the Common Stock on that VWAP Trading Day.

 

“Daily Measurement Value”
means Specified Dollar Amount divided by 30.

 

“Daily Settlement Amount”
for each of the 30 consecutive VWAP Trading Days during the relevant Observation Period, shall consist of:

 

(1)       cash
equal to the lesser of (A) the Daily Measurement Value and (B) the Daily Conversion Value on such VWAP Trading Day; and

 

(2)       if
the Daily Conversion Value on such VWAP Trading Day exceeds the Daily Measurement Value, a number of shares of Common Stock equal
to (A) the difference between the Daily Conversion Value and the Daily Measurement Value, divided by (B) the
Daily VWAP for such VWAP Trading Day.

 

“Daily VWAP” means,
for each of the 30 consecutive VWAP Trading Days during the applicable Observation Period, the per share volume-weighted
average price as displayed under the heading “Bloomberg VWAP” on Bloomberg page “EXAS <equity>
AQR” (or its equivalent successor if such page is not available) in respect of the period from the scheduled open of
trading until the scheduled close of trading of the primary trading session on such VWAP Trading Day (or if such
volume-weighted average price is unavailable, the market value of one share of the Common Stock on such VWAP Trading Day
reasonably determined, using a volume weighted average method, by a nationally recognized independent investment banking firm
retained for this purpose by the Company). The Daily VWAP will be determined without regard to after-hours trading or any
other trading outside of the regular trading session trading hours.

 

    - 4 -

     

    

 

“Default” means any event
which is, or after notice or passage of time or both would be, an Event of Default.

 

“Defaulted Interest” has
the meaning specified in Section 2.06.

 

“Depositary” means the
clearing agency registered under the Exchange Act that is designated to act as the Depositary for the Global Notes. DTC shall be
the initial Depositary, until a successor shall have been appointed and become such pursuant to the applicable provisions of the
Indenture, and thereafter, “Depositary” shall mean or include such successor.

 

“DTC” means The Depository
Trust Company.

 

“Effective Date” has the
meaning specified in Section 10.03, except that, as used in Section 10.04, “Effective Date” means the first
date on which the shares of Common Stock trade on the Relevant Stock Exchange, regular way, reflecting the relevant share split
or share combination, as applicable.

 

“Event of Default” has
the meaning specified in Section 6.01.

 

“Ex-Dividend Date” means
the first date on which the shares of Common Stock trade on the applicable exchange or in the applicable market, regular way, without
the right to receive the issuance, dividend or distribution in question from the Company or, if applicable, from the seller of
Common Stock on such exchange or market (in the form of due bills or otherwise) as determined by such exchange or market. For the
avoidance of doubt, any alternative trading convention on the applicable exchange or market in respect of the Common Stock under
a separate ticker symbol or CUSIP number shall not be considered “regular way” for this purpose.

 

“Exchange Act” means the
Securities Exchange Act of 1934, as amended, and the rules and regulations of the SEC promulgated thereunder.

 

“Expiration Date” has the
meaning specified in Section 10.04(e).

 

“Fundamental Change” shall
be deemed to have occurred when any of the following has occurred:

 

(1)       a
 “person” or “group,” other than the Company and its Wholly Owned Subsidiaries files a Schedule TO or any
schedule, form or report under the Exchange Act disclosing that such person or group has becomes the “beneficial owner”
(as these terms are defined in Rule 13d-3 and Rule 13d-5 under the Exchange Act), directly or indirectly, of more than 50% of the
Company’s Capital Stock that is at the time entitled to vote by the holder thereof in the election of the Board of Directors
(or comparable body);

 

    - 5 -

     

    

 

(2)       the
consummation of (A) any recapitalization, reclassification or change of the Common Stock (other than changes resulting from a subdivision
or combination) as a result of which the Common Stock would be converted into, or exchanged for, stock, other securities or other
property or assets; (B) any share exchange, consolidation or merger of the Company pursuant to which the Common Stock shall be
converted into cash, securities or other property or assets (or any combination thereof); or (C) any sale, lease or other transfer
in one transaction or a series of transactions of all or substantially all of the consolidated assets of the Company and its Subsidiaries,
taken as a whole, to any Person other than one of the Company’s Wholly Owned Subsidiaries; provided, however,
that neither (a) a transaction described in clause (B) in which the holders of all classes of the Company’s common equity
immediately prior to such transaction own, directly or indirectly, more than 50% of all classes of common equity of the continuing
or surviving corporation or transferee or the parent thereof immediately after such transaction in substantially the same proportions
as such ownership immediately prior to such transaction nor (b) any reorganization or merger of the Company solely for the purpose
of changing its jurisdiction of incorporation that results in a reclassification, conversion or exchange of outstanding shares
of Common Stock solely into shares of common stock of the surviving entity shall be a fundamental change pursuant to this clause
(2);

 

(3)       the
adoption of a plan relating to the Company’s liquidation or dissolution; or

 

(4)       the
Common Stock or other shares of Capital Stock or Reference Property into which the Notes are convertible is neither listed for
trading on The New York Stock Exchange, the Nasdaq Capital Market, the Nasdaq Global Market or the Nasdaq Global Select Market
(or any of their respective successors);

 

provided, however, that any transaction or event
described above shall not constitute a Fundamental Change if, in connection with such transaction or event, or as a result therefrom,
a transaction described in clause (1) or (2) above occurs and at least 90% of the consideration paid for the Common Stock (excluding
cash payments for fractional shares and cash payments made pursuant to dissenters’ appraisal rights) consists of shares of
common stock traded on any of The New York Stock Exchange, the Nasdaq Capital Market, the Nasdaq Global Market or the Nasdaq Global
Select Market (or any of their respective successors) (or shall be so traded or quoted immediately following the completion of
the merger or consolidation or such other transaction) and, as a result of such transaction, the Notes become convertible into
a combination of cash (in respect of an amount up to, and including, the principal portion of such Notes) and Reference Property
comprised of such consideration as described under Section 10.05.

 

“Fundamental Change Company Notice”
has the meaning specified in Section 3.01(b).

 

“Fundamental Change Repurchase Date”
has the meaning specified in Section 3.01(a).

 

    - 6 -

     

    

 

“Fundamental Change Repurchase Expiration
Time” has the meaning specified in Section 3.01(a)(1).

 

“Fundamental Change Repurchase Notice”
has the meaning specified in Section 3.01(a)(1).

 

“Fundamental Change Repurchase Price”
has the meaning specified in Section 3.01(a).

 

“Global Notes” has the
meaning specified in Section 2.02.

 

“Holder” means the Person
in whose name a Note is registered on the Registrar’s books.

 

“interest” means, when
used with reference to the Notes, any interest payable under the terms of the Notes, including Defaulted Interest, if any, and
Additional Interest, if any.

 

“Interest Payment Date”
has the meaning specified in Section 2.03(c).

 

“Make-Whole Fundamental Change”
has the meaning specified in Section 10.03.

 

“Market Disruption Event”
means (1) a failure by the Relevant Stock Exchange to open for trading during its regular trading session; or (2) the occurrence
or existence prior to 1:00 p.m., New York City time, on any Scheduled Trading Day for the Common Stock for more than one half-hour
period in the aggregate during regular trading hours of any suspension or limitation imposed on trading (by reason of movements
in price exceeding limits permitted by the Relevant Stock Exchange or otherwise) in the Common Stock or in any options contracts
or futures contracts relating to the Common Stock.

 

“Maturity Date” means March
1, 2028.

 

“Measurement Period” has
the meaning specified in Section 10.01(b)(4).

 

“Merger Event” has the
meaning specified in Section 10.05.

 

“Notes” means any Notes
issued, authenticated and delivered under the Indenture, including any Global Notes.

 

“Notice of Default” has
the meaning specified in Section 6.01.

 

“Observation Period” means,
with respect to any Note surrendered for conversion:

 

(1)       if
the relevant Conversion Date occurs prior to September 1, 2027, the 30 consecutive VWAP Trading Day period beginning on, and including,
the second VWAP Trading Day immediately succeeding such Conversion Date; or

 

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(2)       if
the relevant Conversion Date occurs on or after September 1, 2027, the 30 consecutive VWAP Trading Day period beginning on, and
including, the 32nd Scheduled Trading Day immediately preceding the Maturity Date.

 

“Open of Business” means
9:00 a.m., New York City time.

 

“Opinion of Counsel” means
a written opinion from legal counsel, who is acceptable to the Trustee. The counsel may be an employee of or counsel to the Company.

 

“Person” means any individual,
corporation, partnership, limited liability company, joint venture, association, joint-stock company, trust, unincorporated organization,
government or any agency or political subdivision thereof or any other entity.

 

“Physical Settlement” has
the meaning set forth in Section 10.02(b).

 

“Preferred Stock”, as applied
to the Capital Stock of any Person, means Capital Stock of any class or classes (however designated) that is preferred as to the
payment of dividends, or as to the distribution of assets upon any voluntary or involuntary liquidation or dissolution of such
Person, over shares of Capital Stock of any other class of such Person.

 

“Preliminary Prospectus Supplement”
means the Preliminary Prospectus Supplement, dated February 24, 2020, relating to the offering and sale by the Company of the Notes.

 

“protected purchaser” has
the meaning specified in Section 2.05.

 

“Record Date” means, in
respect of a dividend or distribution to holders of Common Stock, the date fixed for determination of holders of Common Stock entitled
to receive such dividend or distribution.

 

“Reference Property” has
the meaning specified in Section 10.05.

 

“Regular Record Date” means,
with respect to any Interest Payment Date on the Notes, the February 15 and August 15 (whether or not a Business Day) preceding
the applicable March 1 and September 1 Interest Payment Date, respectively.

 

“Relevant Stock Exchange”
means the Nasdaq Capital Market or, if the Common Stock is not then listed on the Nasdaq Capital Market, the principal other U.S.
national or regional securities exchange on which the Common Stock is then listed.

 

“Responsible Officer” means,
when used with respect to the Trustee, any officer within the corporate trust department of the Trustee, including any vice president,
assistant vice president, assistant secretary, senior associate, associate, trust officer or any other officer of the Trustee who
customarily performs functions similar to those performed by the Persons who at the time shall be such officers, respectively,
or to whom any corporate trust matter is referred because of such person’s knowledge of and familiarity with the particular
subject and who, in each case, shall have direct responsibility for the administration of the Indenture.

 

    - 8 -

     

    

 

“Schedule TO” means a Tender
Offer Statement under Section 14(d)(1) or 13(e)(1) of the Exchange Act.

 

“Scheduled Trading Day”
means a day that is scheduled to be a Trading Day on the Relevant Stock Exchange. If the Common Stock is not so listed or admitted
for trading, “Scheduled Trading Day” means a Business Day.

 

“SEC” means the Securities
and Exchange Commission.

 

“Securities Act” means
the Securities Act of 1933, as amended.

 

“Settlement Amount” has
the meaning set forth in Section 10.02(b)(iii).

 

“Settlement Method” means,
with respect to any conversion of Notes, Physical Settlement, Cash Settlement or Combination Settlement, as elected (or deemed
to have been elected) by the Company.

 

“Significant Subsidiary”
with respect to any Person means any Subsidiary of such Person that constitutes a “significant subsidiary” within the
meaning of Rule 1-02(w) under Regulation S-X under the Exchange Act; provided that, in the case of a Subsidiary that meets the
criteria of clause (3) of the definition thereof but not clause (1) or (2) thereof, such Subsidiary shall not be deemed to be a
Significant Subsidiary unless the Subsidiary’s income from continuing operations before income taxes, extraordinary items
and cumulative effect of a change in accounting principle, exclusive of amounts attributable to any non-controlling interests,
for the last completed fiscal year prior to the date of such determination exceeds $25,000,000.

 

“Special Interest Payment Date”
has the meaning specified in Section 2.06(a).

 

“Special Record Date” has
the meaning specified in Section 2.06(a).

 

“Specified Dollar Amount”
means the maximum cash amount per $1,000 principal amount of Notes to be received upon conversion as specified (or deemed specified)
by the Company in the notice specifying the Company’s chosen Settlement Method.

 

“Spin-off” has the meaning
specified in Section 10.04(c).

 

“Stock Price” means, with
respect to any Make-Whole Fundamental Change:

 

(1)       if
holders of the Common Stock receive only cash in such Make-Whole Fundamental Change, the cash amount paid (or deemed paid) per
share; or

 

(2)       otherwise,
the average of the Closing Sale Prices of the Common Stock over the five Trading Day period ending on, and including, the Trading
Day immediately preceding the Effective Date of such Make-Whole Fundamental Change.

 

“Subsidiary” of any
Person means any corporation, association, partnership or other business entity of which more than 50% of the total voting
power of shares of Capital Stock or other interests (including partnership interests) entitled (without regard to the
occurrence of any contingency) to vote in the election of directors, managers or trustees thereof is at the time owned or
controlled, directly or indirectly, by (i) such Person, (ii) such Person and one or more Subsidiaries of such Person or (iii)
one or more Subsidiaries of such Person.

 

    - 9 -

     

    

 

“Successor Company” has
the meaning specified in Section 5.01(a).

 

“Trading Day” means a day
on which:

 

(1)       trading
in the Common Stock generally occurs on the Relevant Stock Exchange or, if the Common Stock is not then listed on a Relevant Stock
Exchange, on the principal other market on which the Common Stock is then traded; and

 

(2)       a
Closing Sale Price for the Common Stock is available on such securities exchange or market.

 

If the Common Stock is not so listed or traded,
 “Trading Day” means a Business Day.

 

“Trading Price” of the
Notes on any date of determination means the average of the secondary market bid quotations per $1,000 principal amount of Notes
obtained by the Bid Solicitation Agent for $5,000,000 principal amount of the Notes at approximately 3:30 p.m., New York City time,
on such determination date from three independent nationally recognized securities dealers selected by the Company for this purpose,
which may include one or more of the Underwriters; provided that if three such bids cannot reasonably be obtained by the
Bid Solicitation Agent but two such bids are obtained, then the average of the two bids shall be used, and if only one such bid
can reasonably be obtained by the Bid Solicitation Agent, then that one bid shall be used. If the Bid Solicitation Agent cannot
reasonably obtain at least one bid for $5,000,000 principal amount of the Notes from a nationally recognized securities dealer
or, in its reasonable judgment, the bid quotations are not indicative of the secondary market value of the Notes, then, for purposes
of the Trading Price conversion contingency described in Section 10.01(b)(4) only, the Trading Price of the Notes shall be deemed
to be less than 98% of the product of the Closing Sale Price of the Common Stock and the Conversion Rate on such Trading Day. If
(x) the Company is not acting as the Bid Solicitation Agent, and the Company does not instruct the Bid Solicitation Agent to obtain
bids when required (as described in Section 10.01(b)(4)), or if the Company so instructs the Bid Solicitation Agent but the Bid
Solicitation Agent fails to carry out such instruction or (y) the Company is acting as Bid Solicitation Agent and the Company fails
to make such determination, then, in either case, the Trading Price per $1,000 principal amount of the Notes shall be deemed to
be less than 98% of the product of the Closing Sale Price of the Common Stock and the Conversion Rate on each day the Bid Solicitation
Agent or the Company, as applicable, fails to do so.

 

“Trigger Event” has the
meaning specified in Section 10.04(c).

 

“Trust Indenture Act” means
the Trust Indenture Act of 1939, as amended.

 

“Trustee” means the party
named as such in the Indenture until a successor replaces it and, thereafter, means the successor.

 

    - 10 -

     

    

 

“Underwriters” means BofA
Securities, Inc., Robert W. Baird & Co. Incorporated, Cowen and Company, LLC, William Blair & Company, L.L.C., BTIG, LLC,
and Stifel, Nicolaus & Company, Incorporated.

 

“Underwriting Agreement”
means the Underwriting Agreement dated February 24, 2020 among the Company and the Underwriters relating to the offer and sale
of the Notes.

 

“Uniform Commercial Code”
means the New York Uniform Commercial Code as in effect from time to time.

 

“Valuation Period” has
the meaning specified in Section 10.04(c).

 

“VWAP Trading Day” means
a day on which:

 

(1)       there
is no Market Disruption Event; and

 

(2)       trading
in the Common Stock generally occurs on the Relevant Stock Exchange.

 

If the Common Stock is not so listed or admitted
for trading on any Relevant Stock Exchange, “VWAP Trading Day” means a “Business Day.”

 

“Wholly Owned Subsidiary”
means a Subsidiary of the Company, all the Capital Stock of which (other than directors’ qualifying shares) is owned by the
Company or another Wholly Owned Subsidiary.

 

Article
2

The Notes

 

Section
2.01.        Designation,
Amount and Issuance of Notes. The Notes shall be designated as “0.3750% Convertible Senior Notes due 2028.” The
Notes shall not exceed the aggregate principal amount of $1,150,000,000 (except pursuant to this Section or Sections 3.4 and 3.6
of the Base Indenture). Upon the execution of the Indenture, or from time to time thereafter, Notes may be executed by the Company
and delivered to the Trustee for authentication.

 

The Company may, without the consent of, or
notice to, Holders, issue additional Notes hereunder in the future on the same terms and conditions of the Notes issued hereunder
(other than differences in the issue price and interest accrued prior to the issue date of such additional Notes) in an unlimited
aggregate principal amount (such additional Notes, the “Additional Notes”); provided that if any such
Additional Notes are not fungible with the Notes initially issued hereunder for U.S. federal income tax purposes, such Additional
Notes will have one or more separate CUSIP numbers. The Notes initially issued hereunder and any such Additional Notes shall rank
equally and ratably and shall be treated as a single series for all purposes under the Indenture. The Company may not issue any
Additional Notes if any Event of Default has occurred with respect to the Notes.

 

    - 11 -

     

    

 

Section
2.02.        Form
of the Notes. The Notes and the Trustee’s certificate of authentication to be borne by such Notes shall be substantially
in the form set forth in Exhibit A hereto. The terms and provisions contained in the form of Notes attached as Exhibit
A hereto shall constitute, and are hereby expressly made, a part of the Indenture and, to the extent applicable, the Company
and the Trustee, by their execution and delivery of the Indenture, expressly agree to such terms and provisions and to be bound
thereby.

 

So long as the Notes are eligible for book-entry
settlement with the Depositary, or unless otherwise required by law, or otherwise contemplated by Section 2.04, all of the Notes
shall be evidenced by one or more Notes in global form registered in the name of the Depositary or the nominee of the Depositary
(the “Global Notes”). The transfer and exchange of beneficial interests in any such Global Notes shall be effected
through the Depositary in accordance with the Indenture and the applicable procedures of the Depositary. Except as provided in
Section 2.04, beneficial owners of a Global Note shall not be entitled to have certificates registered in their names, shall not
receive or be entitled to receive physical delivery of certificates in definitive registered form and shall not be considered holders
of such Global Note.

 

Section
2.03.        Date
and Denomination of Notes; Payment at Maturity; Payment of Interest.

 

(a)              
Date and Denomination. The Notes shall be issuable in registered form without coupons in minimum denominations
of $1,000 principal amount and integral multiples of $1,000 in excess thereof. Each Note shall be dated the date of its authentication
and shall bear interest from the date specified on the face of the Notes.

 

(b)              
Payment at Maturity. Each Holder shall be entitled to receive on the Maturity Date, per $1,000 principal amount
of Notes, $1,000 in cash, together with accrued and unpaid interest thereon to, but excluding, the Maturity Date, unless such Note
is earlier converted or repurchased. With respect to Global Notes, the Company shall pay or cause the Paying Agent to pay principal
and any interest to the Depositary in immediately available funds. With respect to any certificated Notes, principal and any interest
shall be payable at the Company’s office or agency, which initially shall be the Corporate Trust Office of the Trustee.

 

(c)              
Payment of Interest. Interest on the Notes shall accrue at the rate of 0.3750% per annum from February 27,
2020 or from the most recent date to which interest has been paid or duly provided for. Interest shall be payable in arrears on
March 1 and September 1 of each year (each, an “Interest Payment Date”), commencing September 1, 2020, to the
Person in whose name any Note is registered as it appears on the Register at the Close of Business on the applicable Regular Record
Date; provided, however, as and to the extent provided in Section 10.02(d), if a Holder converts any Notes after
the Close of Business on the Regular Record Date but prior to the corresponding Interest Payment Date, interest shall be payable,
on the earlier of the corresponding Interest Payment Date and the date the Company delivers the Settlement Amount in respect of
such conversion, to the Person in whose name any Note is registered as it appears on the Register at the Close of Business on the
applicable Regular Record Date.

 

    - 12 -

     

    

 

Interest on the Notes shall be calculated
on the basis of a 360-day year consisting of twelve 30-day months and, for partial months, on the number of days actually elapsed
in a 30-day month.

 

The Company shall pay or cause the Paying
Agent to pay interest on:

 

(1)       any
Global Notes to the Depositary in immediately available funds;

 

(2)       any
Notes in certificated form having a principal amount of less than $2,000,000 by check mailed to the address of the Person in whose
name such Notes are registered as it appears in the Register; and

 

(3)       any
Notes in certificated form having a principal amount of $2,000,000 or more, either by check mailed to the address of the Person
in whose name such Notes are registered as it appears in the Register or, upon application by such Holder to the Registrar not
later than the relevant Regular Record Date, by wire transfer in immediately available funds to that Holder’s account within
the United States, which application shall remain in effect until the Holder notifies, in writing, the Registrar to the contrary.

 

Section
2.04.        Exchange
of Global Notes. The following provisions shall apply only to Global Notes:

 

(a)              
Each Global Note authenticated under the Indenture shall be registered in the name of the Depositary or a nominee
thereof and delivered to such Depositary or a nominee thereof or custodian for the Global Notes therefor, and each such Global
Note shall constitute a single Note for all purposes of the Indenture.

 

(b)              
Notwithstanding any other provision in the Indenture, no Global Note may be exchanged in whole or in part for Notes
registered, and no transfer of a Global Note in whole or in part may be registered, in the name of any Person other than the Depositary
or a nominee thereof unless:

 

(i)                
the Depositary has notified the Company that it is unwilling or unable to continue as Depositary for such Global
Note and a successor Depositary has not been appointed within 60 days;

 

(ii)             
the Depositary has ceased to be registered as a clearing agency under the Exchange Act and a successor Depositary
has not been appointed within 60 days; or

 

(iii)           
an Event of Default with respect to the Notes has occurred and is continuing and such beneficial owner requests that
its Notes be issued in physical, certificated form.

 

(c)               In
addition, certificated Notes shall be issued in exchange for beneficial interests in a Global Note upon request by or on
behalf of the Depositary in accordance with customary procedures following the request of a beneficial owner seeking to
enforce its rights under the Notes or the Indenture, including its rights following the occurrence of an Event of
Default.

 

    - 13 -

     

    

 

(d)              
Notes issued in exchange for a Global Note or for any portion of a Global Note pursuant to clause (ii) or (iii) above
shall be issued in definitive, fully registered form, without interest coupons, shall have an aggregate principal amount equal
to that of such Global Notes or portion thereof to be so exchanged, shall be registered in such names and be in such authorized
denominations as the Depositary shall designate and shall bear any legends required hereunder. Any Global Notes to be exchanged
shall be surrendered by the Depositary to the Trustee, as Registrar; provided that pending completion of the exchange of
a Global Note, the Trustee acting as custodian of the Global Notes for the Depositary or its nominee with respect to such Global
Notes, shall reduce the principal amount thereof, by an amount equal to the portion thereof to be so exchanged, by means of an
appropriate adjustment made on the books and records of the Trustee. Upon any such surrender or adjustment, the Trustee shall authenticate
and make available for delivery the Notes issuable on such exchange to or upon the written order of the Depositary or an authorized
representative thereof.

 

(e)              
In the event of the occurrence of any of the events specified in clause (ii) above or upon any request described
in clause (iii) above, the Company shall promptly make available to the Trustee a sufficient supply of certificated Notes in definitive,
fully registered form, without interest coupons.

 

(f)               
Neither any members of, or participants in, the Depositary (the “Agent Members”) nor any other
Persons on whose behalf Agent Members may act shall have any rights under the Indenture with respect to any Global Notes registered
in the name of the Depositary or any nominee thereof, and the Depositary or such nominee, as the case may be, may be treated by
the Company, the Trustee and any agent of the Company or the Trustee as the absolute owner and holder of such Global Notes for
all purposes whatsoever. Notwithstanding the foregoing, nothing herein shall prevent the Company, the Trustee or any agent of the
Company or the Trustee from giving effect to any written certification, proxy or other authorization furnished by the Depositary
or such nominee, as the case may be, or impair, as between the Depositary, its Agent Members and any other Person on whose behalf
an Agent Member may act, the operation of customary practices of such Persons governing the exercise of the rights of a Holder
of any Notes.

 

(g)              
At such time as all interests in a Global Note have been repurchased, converted, cancelled or exchanged for Notes
in certificated form, such Global Note shall, upon receipt thereof, be cancelled by the Trustee in accordance with standing procedures
and instructions existing between the Depositary and the custodian for the Global Note. At any time prior to such cancellation,
if any interest in a Global Note is repurchased, converted, cancelled or exchanged for Notes in certificated form, the principal
amount of such Global Note shall, in accordance with the standing procedures and instructions existing between the Depositary and
the custodian for the Global Note, be appropriately reduced, and an endorsement shall be made on such Global Note, by the Trustee
or the custodian for the Global Note, at the direction of the Trustee, to reflect such reduction.

 

    - 14 -

     

    

 

Section
2.05.        Outstanding
Notes. Notes outstanding at any time are all Notes authenticated by the Trustee except for those cancelled by it, those delivered
to it for cancellation and those described in this Section as not outstanding. A Note does not cease to be outstanding because
the Company or an Affiliate of the Company holds the Note.

 

If a Note is replaced pursuant to Section
3.6 of the Base Indenture, it ceases to be outstanding unless the Trustee and the Company receive proof satisfactory to them that
the replaced Note is held by a protected purchaser (as defined in Section 8-303 of the Uniform Commercial Code).

 

If the Paying Agent segregates and holds in
trust, in accordance with the Indenture, on a Fundamental Change Repurchase Date or Maturity Date money sufficient to pay all principal
and interest payable on that date with respect to the Notes (or portions thereof) to be repurchased or maturing, as the case may
be, and the Paying Agent is not prohibited from paying such money to the Holders on that date pursuant to the terms of the Indenture,
then on and after that date such Notes (or portions thereof) cease to be outstanding and interest on them ceases to accrue.

 

Section
2.06.        Defaulted
Interest. Any interest on any Note which is payable, but is not paid when the same becomes due and payable and such nonpayment
continues for a period of 30 calendar days, shall forthwith cease to be payable to the Holder on the Regular Record Date, and such
defaulted interest and interest (to the extent lawful) on such defaulted interest at the annual rate borne by the Notes (such defaulted
interest and interest thereon herein collectively called “Defaulted Interest”) shall be paid by the Company
at its election, in each case, as provided in clause (a) or (b) below:

 

(a)               The
Company may elect to make payment of any Defaulted Interest to the Persons in whose names the Notes (or their respective
predecessor Notes) are registered at the Close of Business on a Special Record Date (as defined below) for the payment of
such Defaulted Interest, which shall be fixed in the following manner. The Company shall notify the Trustee in writing of the
amount of Defaulted Interest proposed to be paid on each Note and the date (not less than 30 calendar days after such notice)
of the proposed payment (the “Special Interest Payment Date”), and at the same time the Company shall
deposit with the Trustee an amount of money equal to the aggregate amount proposed to be paid in respect of such Defaulted
Interest or shall make arrangements satisfactory to the Trustee for such deposit prior to the date of the proposed payment,
such money when deposited to be held in trust for the benefit of the Persons entitled to such Defaulted Interest as in this
clause provided. Thereupon the Company shall fix a record date (the “Special Record Date”) for the payment
of such Defaulted Interest which shall be not more than fifteen calendar days and not less than ten calendar days prior to
the Special Interest Payment Date and not less than ten calendar days after the receipt by the Trustee of the notice of the
proposed payment. The Company shall promptly notify the Trustee of such Special Record Date and shall promptly cause notice
of the proposed payment of such Defaulted Interest and the Special Record Date and Special Interest Payment Date therefor to
be given to each Holder, not less than ten calendar days prior to such Special Record Date. Notice of the proposed payment of
such Defaulted Interest and the Special Record Date and Special Interest Payment Date therefor having been so given, such
Defaulted Interest shall be paid on the Special Interest Payment Date to the Persons in whose names the Notes (or their
respective predecessor Notes) are registered at the Close of Business on such Special Record Date and shall no longer be
payable pursuant to the following clause (b).

 

    - 15 -

     

    

 

(b)              
The Company may make payment of any Defaulted Interest in any other lawful manner not inconsistent with the requirements
of any securities exchange on which the Notes may be listed, and upon such notice as may be required by such exchange, if, after
notice given by the Company to the Trustee of the proposed payment pursuant to this clause, such manner of payment shall be deemed
practicable by the Trustee.

 

(c)              
Subject to the foregoing provisions of this Section 2.06, each Note delivered under the Indenture upon registration
of, transfer of or in exchange for or in lieu of any other Note shall carry the rights to interest accrued and unpaid, and to accrue,
which were carried by such other Note.

 

Section
2.07.        Ranking.
The Notes constitute a senior general unsecured obligation of the Company, ranking equally in right of payment with all existing
and future senior unsecured indebtedness of the Company and ranking senior in right of payment to any future indebtedness of the
Company that is expressly made subordinate to the Notes by the terms of such indebtedness.

 

Article
3

Repurchase of Notes

 

Section
3.01.        Repurchase
at Option of Holders Upon a Fundamental Change. (a) If a Fundamental Change occurs at any time prior to the Maturity Date,
each Holder shall have the right to require the Company to repurchase all or part of such Holder’s Notes in a principal amount
thereof that is equal to $1,000 in principal amount or whole multiples of $1,000 in excess thereof, on the date (the “Fundamental
Change Repurchase Date”) specified by the Company in the Fundamental Change Company Notice that is not less than 20 nor
more than 35 Business Days after the date of the Fundamental Change Company Notice at a repurchase price, payable in cash, equal
to 100% of the principal amount of the Notes being repurchased, plus accrued and unpaid interest to, but excluding, the Fundamental
Change Repurchase Date (the “Fundamental Change Repurchase Price”). However, if such Fundamental Change Repurchase
Date is after a Regular Record Date and on or prior to the corresponding Interest Payment Date, the full amount of interest due
shall be paid on the Interest Payment Date to the Holder of record on the Regular Record Date and the Fundamental Change Repurchase
Price shall be equal to 100% of the principal amount of Notes to be repurchased. The Fundamental Change Repurchase Date shall be
subject to postponement in order to allow the Company to comply with applicable law as a result of changes to such applicable law
occurring after the date of the Indenture. Repurchases of Notes under this Section 3.01 shall be made upon:

 

(1)       delivery
to the Paying Agent by a Holder of a duly completed notice (the “Fundamental Change Repurchase Notice”) in the
form set forth on the reverse of the Note prior to the Close of Business on the Business Day immediately preceding the Fundamental
Change Repurchase Date (the “Fundamental Change Repurchase Expiration Time”); and

 

    - 16 -

     

    

 

 

(2)           delivery
or book-entry transfer of the Notes to the Paying Agent at any time after delivery of the Fundamental Change Repurchase Notice
(together with all necessary endorsements) at the office of the Paying Agent (which, if the Trustee is acting as the Paying Agent,
shall be the Corporate Trust Office), such delivery being a condition to receipt by the Holder of the Fundamental Change Repurchase
Price therefor; provided that such Fundamental Change Repurchase Price shall be so paid pursuant to this Section 3.01 only
if the Notes so delivered to the Paying Agent shall conform in all respects to the description thereof in the related Fundamental
Change Repurchase Notice.

 

The Fundamental Change Repurchase Notice shall
state:

 

(i)         
with respect to Global Notes, the appropriate Depositary information and, with respect to certificated Notes, the
certificate numbers, if any, of the Notes to be tendered for repurchase;

 

(ii)        
the portion of the principal amount of the Notes to be repurchased, which must be $1,000 or whole multiples of $1,000
in excess thereof; and

 

(iii)       
that the Notes are to be repurchased by the Company pursuant to the applicable provisions of the Notes and the Indenture.

 

Payment of the Fundamental Change Repurchase
Price for Notes for which a Fundamental Change Repurchase Notice has been delivered and not withdrawn is conditioned upon book-entry
transfer or delivery of the Notes, together with necessary endorsements, to the Paying Agent, as the case may be. Payment of the
Fundamental Change Repurchase Price for the Notes shall be made promptly following the later of the Fundamental Change Repurchase
Date and the time of book-entry transfer or delivery of the Notes, as the case may be.

 

All questions as to the validity, eligibility
(including time of receipt) and acceptance of any Notes for repurchase shall be determined by the Company, whose determination
shall be final and binding absent manifest error.

 

Notwithstanding anything herein to the contrary,
any Holder delivering to the Paying Agent the Fundamental Change Repurchase Notice contemplated by this Section 3.01 shall have
the right to withdraw such Fundamental Change Repurchase Notice at any time prior to the Fundamental Change Repurchase Expiration
Time by delivering a written notice of withdrawal to the Paying Agent in accordance with Section 3.02 below.

 

The Paying Agent shall promptly notify the
Company of the receipt by it of any Fundamental Change Repurchase Notice or written notice of withdrawal thereof.

 

(b)          
On or before the tenth Business Day after the occurrence of a Fundamental Change, the Company shall provide to all
Holders on the date of the Fundamental Change at their addresses shown in the Register of the Registrar and to beneficial owners
to the extent required by applicable law, the Trustee and the Paying Agent appointed in connection with the Fundamental Change
a written notice (the “Fundamental Change Company Notice”) of the occurrence of the Fundamental Change and the
resulting repurchase right.

 

    - 17 -

     

    

 

Each Fundamental Change Company Notice shall
specify, among other things:

 

(i)        
the events causing the Fundamental Change;

 

(ii)       
the date of the Fundamental Change;

 

(iii)      
the Fundamental Change Repurchase Date;

 

(iv)      
the last date on which a repurchase upon a Fundamental Change may be exercised, which shall be the Business Day immediately
preceding the Fundamental Change Repurchase Date;

 

(v)       
the Fundamental Change Repurchase Price;

 

(vi)      
the names and addresses of the Paying Agent and the Conversion Agent;

 

(vii)     
the procedures that a Holder must follow to exercise the right to repurchase upon a Fundamental Change;

 

(viii)    
that the Fundamental Change Repurchase Price for any Notes as to which a Fundamental Change Repurchase Notice has
been given and not withdrawn shall be paid on the later of such Fundamental Change Repurchase Date and the time of book-entry transfer
or delivery of the Notes (together with all necessary endorsements);

 

(ix)       
that, except as otherwise provided herein with respect to a Fundamental Change Repurchase Date that is after a Regular
Record Date for the payment of an installment of interest and on or before the related Interest Payment Date, on and after such
Fundamental Change Repurchase Date (unless there shall be a Default in the payment of the Fundamental Change Repurchase Price),
interest on Notes subject to repurchase upon Fundamental Change shall cease to accrue, and all rights of the Holders of such Notes
shall terminate, other than the right to receive, in accordance herewith, the Fundamental Change Repurchase Price;

 

(x)         that
a Holder shall be entitled to withdraw its election in the Fundamental Change Repurchase Notice prior to the Close of
Business on the Business Day immediately preceding the Fundamental Change Repurchase Date, by means of a letter or facsimile
transmission (receipt of which is confirmed and promptly followed by a letter) setting forth the name of such Holder, a
statement that such Holder is withdrawing its election to have Notes purchased by the Company on such Fundamental Change
Repurchase Date pursuant to a repurchase upon a Fundamental Change, the certificate number(s) of such Notes to be so
withdrawn, if such Notes are certificated Notes, the principal amount of the Notes of such Holder to be so withdrawn, which
amount must be $1,000 or an integral multiple thereof and the principal amount, if any, of the Notes of such Holder that
remain subject to the Fundamental Change Repurchase Notice delivered by such Holder in accordance with this Section 3.01,
which amount must be $1,000 or an integral multiple thereof; provided, however, that if there shall be a
Default in the payment of the Fundamental Change Repurchase Price, a Holder shall be entitled to withdraw its election in the
Fundamental Change Repurchase Notice at any time during which such Default is continuing;

 

    - 18 -

     

    

 

(xi)       
the Conversion Rate and any adjustments to the Conversion Rate that shall result from such Fundamental Change;

 

(xii)      
that Notes with respect to which a Fundamental Change Repurchase Notice is given by a Holder may be converted pursuant
to Article 10 only if such Fundamental Change Repurchase Notice has been withdrawn in accordance with Section 3.02 or the Company
defaults in the payment of the Fundamental Change Repurchase Price;

 

(xiii)     
the CUSIP number or numbers, as the case may be, of the Notes; and

 

(xiv)    
the procedures that Holders must follow to require the Company to repurchase their Notes.

 

No failure of the Company to give the foregoing notices and
no defect therein shall limit the repurchase rights of Holders or affect the validity of the proceedings for the repurchase of
the Notes pursuant to this Section 3.01.

 

(c)          
Notwithstanding the foregoing, no Notes may be repurchased by the Company at the option of the Holders upon a Fundamental
Change if the principal amount of the Notes has been accelerated, and such acceleration has not been rescinded, on or prior to
the Fundamental Change Repurchase Date (except in the case of an acceleration resulting from a Default by the Company in the payment
of the Fundamental Change Repurchase Price with respect to such Notes).

 

(d)          
The Company shall not be required to purchase, or make an offer to purchase, the Notes upon the occurrence of a Fundamental
Change otherwise required under this Section 3.01 if a third party makes such an offer in the same manner, at the same time and
otherwise in compliance with the requirements set forth in the Indenture applicable to such an offer by the Company, and such third
party purchases all Notes properly surrendered and not validly withdrawn upon such offer in the same manner, at the same time and
otherwise in compliance with such requirements.

 

(e)          
The Company shall not be required to give such notice or repurchase the Notes as described in this Section 3.01 upon
a Fundamental Change pursuant to clause (2) of the definition thereof if (1) such Fundamental Change results in the Notes becoming
convertible (pursuant to the Section 10.05) into an amount of cash per Note greater than the Fundamental Change Repurchase Price
(assuming the maximum amount of accrued interest would be payable based on the latest possible Fundamental Change Repurchase Date)
and (2) the Company provides timely notice of the Holders’ right to convert their Notes based on such Fundamental Change
as described under Section 10.01(b)(2).

 

    - 19 -

     

    

 

Section
3.02.        Withdrawal
of Fundamental Change Repurchase Notice. A Fundamental Change Repurchase Notice may be withdrawn by means of a written
notice of withdrawal delivered to the office of the Paying Agent (which, if the Trustee is acting as the Paying Agent, shall
be the Corporate Trust Office) in accordance with the Fundamental Change Repurchase Notice at any time prior to the
Fundamental Change Repurchase Expiration Time, specifying:

 

(1)       with
respect to Global Notes, the appropriate Depositary information and, with respect to certificated Notes, the certificate number,
if any, of the withdrawn Notes;

 

(2)       the
principal amount of the withdrawn Notes (which must be $1,000 or an integral multiple thereof); and

 

(3)       the
principal amount, if any, of such Notes that remains subject to the original Fundamental Change Repurchase Notice, which portion
must be in principal amounts of $1,000 or integral multiples of $1,000 in excess thereof.

 

Section
3.03.        Deposit
of Fundamental Change Repurchase Price. Prior to 10:00 a.m., New York City time, on the Fundamental Change Repurchase Date,
the Company shall deposit with the Paying Agent or, if the Company or a Wholly Owned Subsidiary of the Company is acting as the
Paying Agent, shall segregate and hold in trust as provided in Section 9.3 of the Base Indenture, an amount of cash in immediately
available funds, sufficient to pay the aggregate Fundamental Change Repurchase Price of all the Notes or portions thereof that
are to be repurchased as of the Fundamental Change Repurchase Date.

 

If the Paying Agent holds on the Fundamental
Change Repurchase Date cash sufficient to pay the Fundamental Change Repurchase Price of the Notes that Holders have elected to
require the Company to repurchase in accordance with Section 3.01, then, as of the Fundamental Change Repurchase Date:

 

(i)        
such Notes shall cease to be outstanding and interest shall cease to accrue, whether or not book-entry transfer of
the Notes has been made or the Notes have been delivered to the Paying Agent, as the case may be; and

 

(ii)       
all other rights of the Holders of such Notes shall terminate, other than the right to receive the Fundamental Change
Repurchase Price upon delivery or transfer of the Notes.

 

Section
3.04.        Notes
Repurchased in Part. Upon presentation of any Notes repurchased only in part, the Company shall execute and the Trustee shall
authenticate and make available for delivery to the Holder thereof, at the expense of the Company, a new Note or Notes, of any
authorized denomination, in aggregate principal amount equal to the unrepurchased portion of the Notes presented.

 

Section
3.05.        Covenant
to Comply with Securities Laws Upon Repurchase of Notes. In connection with any repurchase upon a Fundamental Change, the
Company shall, to the extent applicable, (i) comply with the provisions of Rule 13e-4 and any other tender offer rules under
the Exchange Act that may be applicable at the time of the offer to repurchase the Notes; (ii) file a Schedule TO or any
other schedule required in connection with any offer by the Company to repurchase the Notes; and (iii) comply with all other
federal and state securities laws in connection with any offer by the Company to repurchase the Notes.

 

    - 20 -

     

    

 

Article
4

Covenants

 

Article IX of the Base Indenture is hereby supplemented,
with respect to the Notes, to add or replace the following covenants, as indicated:

 

Section
4.01.        Payment
of Notes. The following covenant replaces Section 9.1 of the Base Indenture with respect to the Notes: The Company shall
promptly pay the principal (including the Fundamental Change Repurchase Price, if applicable) of, the Settlement Amount owed on
conversion, and interest on the Notes on the dates and in the manner provided in the Notes and in the Indenture. Principal, Settlement
Amount and interest shall be considered paid on the date due if on such date the Trustee or the Paying Agent holds in accordance
with the Indenture money sufficient to pay all principal, Settlement Amount and interest then due and the Trustee or the Paying
Agent, as the case may be, is not prohibited from paying such money to the Holders on that date pursuant to the terms of the Indenture.

 

The Company shall pay interest on overdue
principal (including the Fundamental Change Repurchase Price, if applicable) and Settlement Amount owed on conversion to the extent
it includes cash, at the rate specified therefor in the Notes, and it shall pay interest on overdue installments of interest at
the rate and in the manner specified in Section 2.06.

 

Section
4.02.        Maintenance
of Office or Agency. The following covenant replaces Section 9.2 of the Base Indenture with respect to the Notes: The
Company shall maintain an office or agency where the Notes may be surrendered for registration of transfer or exchange or for presentation
for payment or for conversion or repurchase and where notices and demands to or upon the Company in respect of the Notes and the
Indenture may be made. As of the date of the Indenture, such office is located at the Corporate Trust Office of the Trustee and,
at any other time, at such other address as the Trustee may designate from time to time by notice to the Company. The Company shall
give prompt written notice to the Trustee of the location, and any change in the location, of such office or agency not designated
or appointed by the Trustee. If at any time the Company shall fail to maintain any such required office or agency or shall fail
to furnish the Trustee with the address thereof, such presentations, surrenders, notices and demands may be made at the Corporate
Trust Office; provided that the Corporate Trust Office shall not be an office or agency of the Company for the purpose of
service of legal process against the Company.

 

The Company may also from time to time designate
co-registrars and one or more offices or agencies where the Notes may be presented or surrendered for any or all such purposes
and may from time to time rescind such designations. The Company shall give prompt written notice to the Trustee of any such designation
or rescission and of any change in the location of any such other office or agency.

 

    - 21 -

     

    

 

Section
4.03.        Reports.
The following covenant replaces Section 9.5 of the Base Indenture with respect to the Notes:

 

(a)           
The Company shall file with the Trustee any documents or reports it is required to file with the SEC pursuant to
Section 13 or 15(d) of the Exchange Act within 15 days after the same are required to be filed with the SEC (giving effect to any
grace period provided by Rule 12b-25 or any successor rule under the Exchange Act). Any document or report that the Company files
with the SEC via the SEC’s EDGAR system (or any successor thereto) shall be deemed to be filed with the Trustee as of the
time such documents are filed via EDGAR (or such successor). The Trustee shall have no obligation to determine if and when the
Company’s statements or reports are publicly available and/or accessible electronically. Notwithstanding anything to the
contrary, the Company shall in no event be required to file with, or otherwise provide or disclose to, the Trustee or any Holder
any information for which the Company is seeking, or has received, confidential treatment from the SEC.

 

(b)          
Delivery of the reports and documents delivered under the Indenture to the Trustee is for informational purposes
only, and the Trustee’s receipt of such shall not constitute actual or constructive notice or knowledge of any information
contained therein or determinable from information contained therein, including the Company’s compliance with any of its
covenants under the Indenture (as to which the Trustee is entitled to conclusively rely on an Officer’s Certificate).

 

Section
4.04.        Compliance
Certificate. The following covenant replaces Section 9.6 of the Base Indenture with respect to the Notes: The Company
shall deliver to the Trustee within 120 calendar days after the end of each fiscal year of the Company (beginning with the fiscal
year ended December 31, 2020) an Officer’s Certificate, stating whether or not, to the knowledge of the Officer (such Officer
being one of the principal executive, financial or accounting officers of the Company) executing such Officer’s Certificate,
any Default or Event of Default occurred during such period and if so, describing each Default or Event of Default, its status
and the action the Company is taking or proposes to take with respect thereto. Such Officer’s Certificate shall also contain
a certification from such Officer that the Company has complied with all conditions and covenants under the Indenture.

 

Section
4.05.        Statement
by Officer as to Default. The Company shall deliver to the Trustee, promptly and in any event 10 calendar days after the Company
becomes aware of the occurrence of any Event of Default or Default, an Officer’s Certificate setting forth the details of
such Event of Default or Default, its status and the action which the Company proposes to take with respect thereto.

 

Section
4.06.        Waiver
of Stay, Extension or Usury Laws. The Company covenants (to the extent it may lawfully do so) that it shall not at any
time insist upon, plead, or in any manner whatsoever claim or take benefit or advantage of, any stay, extension or usury law
or other law which would prohibit or forgive the Company from paying all or any portion of the principal of or interest on
the Notes as contemplated herein, wherever enacted, now or at any time; the Company (to the extent it may lawfully do so)
hereby expressly waives all benefit or advantage of any such law, and covenants that it shall not, by resort to any such law,
hinder, delay or impede the execution of any power herein granted to the Trustee, but shall suffer and permit the execution
of every such power as though no such law had been enacted.

 

    - 22 -

     

    

 

Article
5

Successor Company

 

Article VII of the Base Indenture is hereby replaced in full,
solely with respect to the Notes, with the following:

 

Section
5.01.        When
Company May Merge or Transfer Assets. The Company shall not, in a single transaction or a series of related transactions, consolidate
with or merge with or into any other Person or sell, convey, transfer, lease or otherwise dispose of all or substantially all of
the property and assets of the Company and its Subsidiaries taken as a whole to another Person, unless:

 

(a)          
either (i) the Company is the continuing corporation or (ii) the resulting, surviving or transferee Person (if other
than the Company) (the “Successor Company”) is a corporation organized and existing under the laws of the United
States, any state thereof or the District of Columbia and such Person assumes, by a supplemental indenture, all of the Company’s
obligations under the Notes and the Indenture;

 

(b)          
immediately after giving effect to such transaction, no Default or Event of Default has occurred and is continuing;
and

 

(c)          
the Company has delivered to the Trustee the Officer’s Certificate and Opinion of Counsel pursuant to Section
5.03.

 

Section
5.02.        Successor
to Be Substituted. In case of any such transaction described in Section 5.01 other than a lease in which the Company is
not the surviving corporation and upon the assumption by the Successor Company, by supplemental indenture, executed and
delivered to the Trustee, of the due and punctual payment of the principal of and interest on all of the Notes, and the due
and punctual performance and observance of all of the covenants and conditions of the Indenture to be performed or satisfied
by the Company, such Successor Company shall succeed, and be substituted for, and may exercise every right and power of, the
Company, and Exact Sciences Corporation shall be discharged from its obligations under the Notes and the Indenture, except in
the case of a lease. Such Successor Company thereupon may cause to be signed, and may issue either in its own name or in the
name of Exact Sciences Corporation any or all of the Notes, issuable hereunder that theretofore shall not have been signed by
the Company and delivered to the Trustee; and, upon the order of such Successor Company instead of the Company and subject to
all the terms, conditions and limitations in the Indenture prescribed, the Trustee shall authenticate and shall deliver, or
cause to be authenticated and delivered, any Notes that previously shall have been signed and delivered by the officers of
the Company to the Trustee for authentication, and any Notes that such Successor Company thereafter shall cause to be signed
and delivered to the Trustee for that purpose. All the Notes so issued shall in all respects have the same legal rank and
benefit under the Indenture as the Notes theretofore or thereafter issued in accordance with the terms of the Indenture as
though all of such Notes had been issued at the date of the execution hereof. In the event of any such consolidation, merger,
sale, conveyance, transfer or other disposition, upon compliance with this Article 5, the Person named as the
 “Company” in the first paragraph of the Indenture or any successor that shall thereafter have become such in the
manner prescribed in this Article 5 may be dissolved, wound up and liquidated at any time thereafter and such Person shall be
discharged from its liabilities as obligor and maker of the Notes and from its obligations under the Indenture.

 

    - 23 -

     

    

 

Section
5.03.        Opinion
of Counsel to Be Given Trustee. Prior to execution of any supplemental indenture pursuant to this Article 5, the Trustee shall
receive an Officer’s Certificate and an Opinion of Counsel as conclusive evidence that any such consolidation, merger, sale,
conveyance, transfer, lease or other disposition and any such assumption complies with the provisions of this Article 5.

 

Article
6

 

Defaults and Remedies

 

Article V of the Base Indenture is hereby replaced in full,
solely with respect to the Notes, with the following:

 

Section
6.01.        Events
of Default. An “Event of Default” occurs if:

 

(a)          
the Company fails to pay any interest on the Notes when due and such failure continues for a period of 30 calendar
days;

 

(b)          
the Company fails to pay principal of the Notes when due at maturity, or the Company fails to pay the Fundamental
Change Repurchase Price payable, in respect of any Notes when due;

 

(c)          
the Company fails to comply with its obligations to convert any Notes in accordance with the Indenture, and such
failure continues for five Business Days following the scheduled settlement date for such conversion;

 

(d)          
the Company fails to comply with Article 5;

 

(e)          
the Company fails to provide notice of any transaction described under Section 10.01(b)(2);

 

(f)           
the Company fails to provide notice of a Fundamental Change when due pursuant to Sections 3.01(b) or 10.01(b)(3),
in each case;

 

(g)          
the Company fails to perform or observe any term, covenant or agreement in the Notes or the Indenture (other than
a covenant or agreement a default in whose performance or whose breach is elsewhere in this Section 6.01 specifically dealt with)
for a period of 60 consecutive calendar days after the written notice specified below is given by the Trustee to the Company or
by the Holders of at least 25% in aggregate principal amount of the Notes then outstanding to the Company and the Trustee, as the
case may be;

 

    - 24 -

     

    

 

(h)          
the failure to pay when due (whether at stated maturity or otherwise) or a default that results in the acceleration
of maturity, of any indebtedness for borrowed money of the Company or any of its Subsidiaries in an aggregate amount in excess
of $50,000,000 (or its foreign currency equivalent), unless such indebtedness is paid or discharged, or such acceleration is rescinded,
stayed or annulled, within a period of 30 calendar days after the written notice specified below is given by the Trustee to the
Company or by the Holders of at least 25% in aggregate principal amount of the Notes then outstanding to the Company and the Trustee,
as the case may be;

 

(i)            
a final judgment for the payment in excess of $50,000,000 (or its foreign currency equivalent) (excluding any amounts
covered by insurance) rendered against the Company or any Subsidiary of the Company, which judgment is not paid, discharged, bonded,
waived or stayed within 60 calendar days after (A) the date on which the right to appeal or petition for review thereof has expired
if no such appeal or review has commenced, or (B) the date on which all rights to appeal or petition for review have been extinguished;

 

(j)           
the Company or any of its Significant Subsidiaries pursuant to or within the meaning of any Bankruptcy Law:

 

(1)           commences
a voluntary case;

 

(2)           consents
to the entry of an order for relief against it in an involuntary case;

 

(3)           consents
to the appointment of a Custodian of it or for any substantial part of its property;

 

(4)           makes
a general assignment for the benefit of its creditors; or

 

(5)           or
takes any comparable action under any foreign laws relating to insolvency; or

 

(k)           
a court of competent jurisdiction enters an order or decree under any Bankruptcy Law that:

 

(1)            is
for relief against the Company or any of its Significant Subsidiaries in an involuntary case;

 

(2)           appoints
a Custodian of the Company or any of its Significant Subsidiaries or for any substantial part of its property;

 

(3)           orders
the winding up or liquidation of the Company or any of its Significant Subsidiaries; or

 

(4)           any
similar relief is granted under any foreign laws,

 

and in any case of the foregoing
clauses (1) through (4), such order or decree shall have remained unstayed and in effect for 60 calendar days.

 

    - 25 -

     

    

 

The foregoing shall constitute Events of Default
whatever the reason for any such Event of Default and whether it is voluntary or involuntary or is effected by operation of law
or pursuant to any judgment, decree or order of any court or any order, rule or regulation of any administrative or governmental
body.

 

The term “Bankruptcy Law”
means Title 11, United States Code, or any similar federal or state law for the relief of debtors. The term “Custodian”
means any receiver, trustee, assignee, liquidator, custodian or similar official under any Bankruptcy Law.

 

A Default under clause (g) or (h) of this
Section 6.01 is not an Event of Default until the Trustee notifies the Company or the Holders of at least 25% in aggregate principal
amount of the Notes then outstanding notify the Company and the Trustee, as the case may be, of the Default and the Company does
not cure such Default within the time specified in clause (g) or (h) of this Section 6.01, as applicable, after receipt of such
notice. Such notice must specify the Default, demand that it be remedied and state that such notice is a “Notice of Default”.

 

Section
6.02.        Acceleration.
If an Event of Default (other than an Event of Default specified in Section 6.01(j) or (k) with respect to the Company) occurs
and is continuing, the Trustee by notice to the Company, or the Holders of at least 25% in aggregate principal amount of the outstanding
Notes by written notice to the Company and the Trustee, may declare the principal amount of the Notes and accrued and unpaid interest
on the outstanding Notes to be due and payable. If an Event of Default specified in Section 6.01(j) or (k) with respect to the
Company (and not involving solely one or more of the Company’s Significant Subsidiaries) occurs and is continuing, the principal
amount of the Notes and accrued and unpaid interest on the outstanding Notes shall become and be immediately due and payable without
any declaration or other act on the part of the Trustee or any Holders.

 

After a declaration of acceleration, but before
a judgment or decree for payment of the money due has been obtained by the Trustee, the Holders of a majority in aggregate principal
amount of the Notes outstanding, by written notice to the Company and the Trustee, may rescind and annul such declaration if:

 

(a)          
the Company has paid (or deposited with the Trustee a sum sufficient to pay):

 

(1)           all
overdue interest on all Notes;

 

(2)           the
principal amount of any Notes that have become due otherwise than by such declaration of acceleration;

 

(3)           to
the extent that payment of such interest is lawful, interest upon overdue interest; and

 

(4)           all
sums paid or advanced by the Trustee under the Indenture and the compensation and reasonable expenses, disbursements and advances
of the Trustee, its agents and counsel; and

 

    - 26 -

     

    

 

(b)          
all Events of Default, other than the non-payment of the principal amount of the Notes and any accrued and unpaid
interest that have become due solely by such declaration of acceleration or the failure to deliver consideration upon conversion,
have been cured or waived.

 

No such rescission and annulment shall affect
any subsequent Default or Event of Default or impair any right consequent thereon.

 

Section
6.03.        Other
Remedies. If an Event of Default occurs and is continuing, the Trustee may pursue any available remedy to collect the payment
of principal of or interest on the Notes or to enforce the performance of any provision of the Notes or the Indenture.

 

The Trustee may maintain a proceeding even
if it does not possess any of the Notes or does not produce any of them in the proceeding. A delay or omission by the Trustee or
any Holder in exercising any right or remedy accruing upon an Event of Default shall not impair the right or remedy or constitute
a waiver of or acquiescence in the Event of Default. No remedy is exclusive of any other remedy. All available remedies are cumulative.

 

Section
6.04.        Waiver
of Past Defaults. Subject to Section 6.02, the Holders of a majority in aggregate principal amount of the Notes outstanding
may, on behalf of all Holders of all the Notes, waive any existing and past Default or Event of Default under the Indenture and
its consequences, except:

 

(i)         
the Company’s failure to pay principal of or interest on any Notes when due;

 

(ii)       
the Company’s failure to convert any Notes into cash and, if applicable, Common Stock pursuant to the terms
of the Indenture;

 

(iii)       
the Company’s failure to pay the Fundamental Change Repurchase Price on the Fundamental Change Repurchase Date
in connection with a Holder exercising its repurchase rights; or

 

(iv)      
the Company’s failure to comply with any of the provisions of the Indenture that under Section 9.02 cannot
be amended without the consent of each Holder affected.

 

When a Default is waived, it is deemed cured,
but no such waiver shall extend to any subsequent or other Default or impair any consequent right.

 

Section
6.05.        Control
by Majority. The Holders of a majority in aggregate principal amount of the outstanding Notes shall have the right to
direct the time, method and place of any proceedings for any remedy available to the Trustee or the exercise of any other
right or power conferred on the Trustee. However, the Trustee may refuse to follow any direction that conflicts with law or
the Indenture or, subject to Section 6.01 of the Base Indenture, that the Trustee determines is unduly prejudicial to the
rights of other Holders or would involve the Trustee in personal liability or expense for which the Trustee has not received
adequate indemnity as determined by it in good faith; provided, however, that the Trustee may take any other
action deemed proper by the Trustee that is not inconsistent with such direction. Prior to taking any action hereunder, the
Trustee shall be entitled to indemnity or security satisfactory to it in its sole discretion against all losses, liabilities,
and expenses caused by taking or not taking such action.

 

    - 27 -

     

    

 

Section
6.06.        Limitation
on Suits. Except to enforce the right to receive payment of principal or interest when due or consideration due upon conversion
when due, no Holder may pursue any remedy with respect to the Indenture or the Notes unless:

 

(a)          
such Holder has given the Trustee written notice of an Event of Default;

 

(b)          
the Holders of at least 25% in aggregate principal amount of the outstanding Notes have made a written request to
the Trustee to pursue the remedy, and offered security or indemnity against any costs, liability or expense of the Trustee satisfactory
to the Trustee;

 

(c)          
the Trustee fails to comply with such request within 60 calendar days after receipt of such request and offer of
indemnity; and

 

(d)          
the Trustee has not received an inconsistent direction from the Holders of a majority in aggregate principal amount
of the outstanding Notes.

 

A Holder may not use the Indenture to prejudice
the rights of another Holder or to obtain a preference or priority over another Holder (it being understood that the Trustee shall
not have any affirmative duty to ascertain whether or not such actions or forbearances are unduly prejudicial to such Holders).

 

Section
6.07.        Rights
of Holders to Receive Payment. Notwithstanding any other provision of the Indenture and any provision of any Note, the right
of any Holder to receive payment or delivery, as the case may be, of (x) the principal (including the Fundamental Change Repurchase
Price, if applicable) of, (y) accrued and unpaid interest, if any, on, and (z) the consideration due upon conversion of, such Note,
on or after the respective due dates expressed or provided for in such Note or in the Indenture, or to institute suit for the enforcement
of any such payment or delivery, as the case may be, on or after such respective dates against the Company shall not be impaired
or affected without the consent of such Holder.

 

Section
6.08.        Collection
Suit by Trustee. If an Event of Default specified in Section 6.01(a), (b) or (c) occurs and is continuing, the Trustee may
recover judgment in its own name and as trustee of an express trust against the Company for the whole amount then due and owing
(together with interest on any unpaid interest to the extent lawful) and the amounts provided for in Section 6.8 of the Base Indenture.

 

    - 28 -

     

    

 

Section
6.09.        Trustee
May File Proofs of Claim. In the event there shall be pending proceedings for the bankruptcy or for the reorganization of
the Company or any other obligor on the Notes under title 11 of the United States Code, or any other applicable law, or in
case a Custodian shall have been appointed for or taken possession of the Company or such other obligor, the property of the
Company or such other obligor, or in the event of any other judicial proceedings relative to the Company or such other
obligor upon the Notes, or to the creditors or property of the Company or such other obligor, the Trustee, irrespective of
whether the principal of the Notes shall then be due and payable as therein expressed or by declaration or otherwise and
irrespective of whether the Trustee shall have made any demand pursuant to the provisions of this Section 6.09, shall be
entitled and empowered, by intervention in such proceedings or otherwise, to file and prove a claim or claims for the whole
amount of principal and accrued and unpaid interest, if any, in respect of the Notes, and, in case of any judicial
proceedings, to file such proofs of claim and other papers or documents and to take such other actions as it may deem
necessary or advisable in order to have the claims of the Trustee (including any claim for the reasonable compensation,
expenses, disbursements and advances of the Trustee, its agents and counsel) and of the Holders allowed in such judicial
proceedings relative to the Company or any other obligor on the Notes, its or their creditors, or its or their property, and
to collect and receive any monies or other property payable or deliverable on any such claims, and to distribute the same
after the deduction of any amounts due to the Trustee under Section 6.8 of the Base Indenture; and any Custodian or similar
official is hereby authorized by each of the Holders to make such payments to the Trustee, as administrative expenses, and,
in the event that the Trustee shall consent to the making of such payments directly to the Holders, to pay to the Trustee any
amount due to it for reasonable compensation, expenses, advances and disbursements, including agents and counsel fees, and
including any other amounts due to the Trustee under Section Section 6.8 of the Base Indenture, incurred by it up to the date
of such distribution. To the extent that such payment of reasonable compensation, expenses, advances and disbursements out of
the estate in any such proceedings shall be denied for any reason, payment of the same shall be secured by a lien on, and
shall be paid out of, any and all distributions, dividends, monies, securities and other property that the Holders of the
Notes may be entitled to receive in such proceedings, whether in liquidation or under any plan of reorganization or
arrangement or otherwise.

 

Nothing herein contained shall be deemed to
authorize the Trustee to authorize or consent to or accept or adopt on behalf of any Holder any plan of reorganization, arrangement,
adjustment or composition affecting such Holder or the rights of any Holder thereof, or to authorize the Trustee to vote in respect
of the claim of any Holder in any such proceeding.

 

Section
6.10.        Priorities.
If the Trustee collects any money or property pursuant to this Article 6, it shall pay out the money or property in the following
order:

 

FIRST: to the Trustee for amounts
due under Section 6.8 of the Base Indenture;

 

SECOND: to Holders for amounts
due and unpaid on the Notes for principal (including payments pursuant to the required repurchase provisions of the Notes) and
interest, ratably without preference or priority of any kind, according to the amounts due and payable on the Notes for principal
(including payments pursuant to the required repurchase provisions of the Notes) and interest or in respect of any Conversion Obligation
of the Company, respectively; and

 

THIRD: to the Company.

 

The Trustee may fix a record date and payment
date for any payment to Holders pursuant to this Section 6.10. At least fifteen calendar days before such record date, the Trustee
shall transmit to each Holder and the Company a notice that states the record date, the payment date and amount to be paid.

 

    - 29 -

     

    

 

Section
6.11.        Undertaking
for Costs. In any suit for the enforcement of any right or remedy under the Indenture or in any suit against the Trustee for
any action taken or omitted by it as Trustee, a court in its discretion may require the filing by any party litigant in the suit
of an undertaking to pay the costs of the suit, and the court in its discretion may assess reasonable costs, including reasonable
attorneys’ fees and expenses, against any party litigant in the suit, having due regard to the merits and good faith of the
claims or defenses made by the party litigant. This Section 6.11 does not apply to a suit by the Trustee, a suit by a Holder pursuant
to Section 6.07 or a suit by Holders of more than 10% in principal amount of the Notes.

 

Section
6.12.        Failure
to Comply with Reporting Covenant. Notwithstanding anything to the contrary in the Indenture, the Company may elect that the
sole remedy for an Event of Default relating to the Company’s failure to comply with the covenant in Section 4.03(a), for
the 365 days after the occurrence of such an Event of Default shall consist exclusively of the right to receive Additional Interest
on the Notes at an annual rate equal to (i) 0.25% of the outstanding principal amount of the Notes from the first date of the occurrence
of such Event of Default to, but not including, the 180th day thereafter (or such earlier date on which the Event of
Default relating to the Company’s reporting obligations pursuant to Section 4.03(a) shall have been cured or waived) and
(ii) 0.50% of the outstanding principal amount of the Notes from the 180th date following the occurrence to the 365th
day after the first date of the occurrence of such Event of Default (or such earlier date on which the Event of Default relating
to the Company’s reporting obligations pursuant to Section 4.03(a) shall have been cured or waived). Additional Interest
payable pursuant to this Section 6.12 shall be payable in arrears on each Interest Payment Date following accrual in the same manner
as regular interest payable on the Notes. The Additional Interest payable pursuant to this Section 6.12 shall accrue on all outstanding
Notes from and including the date on which an Event of Default relating to a failure to comply with the Company’s reporting
obligations pursuant to Section 4.03(a) first occurs to, but not including the 366th day thereafter (or such earlier date on which
the Event of Default relating to the Company’s reporting obligations pursuant to Section 4.03(a) shall have been cured or
waived). On such 366th day, if such Event of Default is continuing, such Additional Interest payable pursuant to this Section 6.12
shall cease to accrue and the Notes shall be subject to acceleration as provided in Section 6.02. This Section 6.12 shall not affect
the rights of Holders in the event of the occurrence of any other Event of Default.

 

In the event the Company does not elect
to pay the Additional Interest pursuant to this Section 6.12 or the Company elected to make such payment but does not pay
such Additional Interest when due, the Notes shall be immediately subject to acceleration as provided in Section 6.02. In no
event shall Additional Interest payable pursuant to the foregoing election accrue at a rate per year in excess of the
applicable rate specified in this Section 6.12, regardless of the number of events or circumstances giving rise to
requirements to pay such Additional Interest pursuant to this Section 6.12. The Company shall notify the Trustee in writing
promptly upon its becoming aware of its obligation to pay Additional Interest, the date on which such Additional Interest is
payable and the amount identified as Additional Interest. In no event shall the Trustee be charged with knowledge of whether
such Additional Interest is due, unless it has received the written notice referred to in the preceding sentence.

 

    - 30 -

     

    

 

Article
7

[RESERVED]

 

Article
8

Discharge of Indenture

 

Article IV of the Base Indenture is hereby replaced in full,
solely with respect to the Notes, with the following:

 

Section
8.01.        Discharge
of Liability on Notes. (a) The Indenture shall, subject to Section 8.01(b), cease to be of further effect with respect to the
Notes if:

 

(1)           the
Company (i) delivers all outstanding Notes (other than Notes replaced pursuant to Section 3.6 of the Base Indenture) to the Trustee
for cancellation or (ii) deposits with the Trustee or the Paying Agent after such Notes have become due and payable, whether at
stated maturity, upon conversion, or on any Fundamental Change Repurchase Date, cash or, in the case of conversion, cash or cash
and/or shares of Common Stock, if any, issuable upon conversion (and cash in lieu of fractional shares) (solely to satisfy outstanding
conversions) calculated in accordance with the Indenture sufficient to satisfy all obligations due on all outstanding Notes and
pays all other sums payable under the Indenture; and

 

(2)           the
Company has delivered to the Trustee an Officer’s Certificate and an Opinion of Counsel, each stating that all conditions
precedent provided herein relating to the satisfaction and discharge of the Indenture have been complied with.

 

(b)          
Notwithstanding Section 8.01(a), the Company’s obligations in Sections 2.04 and 2.05 and in this Article 8
shall survive until the Notes have been paid in full. Thereafter, the Company’s obligations in Sections 8.03 and 8.04 shall
survive.

 

Section
8.02.        Application
of Trust Money. The Trustee shall hold in trust money and any shares of Common Stock or other property due in respect of converted
Notes deposited with it pursuant to this Article 8. It shall apply the deposited money through the Paying Agent and in accordance
with the Indenture to the payment of principal of and interest on the Notes or, in the case of any shares of Common Stock or other
property due in respect of converted Notes, in accordance with the Indenture in relation to the conversion of Notes pursuant to
the terms hereof.

 

Section
8.03.        Repayment
to Company. Subject to any applicable abandoned property law, the Trustee and the Paying Agent shall pay to the Company
upon written request any money held by them for the payment of principal or interest and any shares of Common Stock or other
property due in respect of converted Notes that remains unclaimed for two years, and, thereafter, Holders entitled to the
money and/or securities must look to the Company for payment as general creditors.

 

    - 31 -

     

    

 

Section
8.04.        Reinstatement.
If the Trustee or Paying Agent is unable to apply any money or to deliver any shares of Common Stock or other property due in respect
of converted Notes in accordance with this Article 8 by reason of any legal proceeding or by reason of any order or judgment of
any court or governmental authority enjoining, restraining or otherwise prohibiting such application, the Company’s obligations
under the Indenture and the Notes shall be revived and reinstated as though no deposit had occurred pursuant to this Article 8
until such time as the Trustee or Paying Agent is permitted to apply all such money and any shares of Common Stock or other property
due in respect of converted Notes in accordance with this Article 8; provided, however, that, if the Company has
made any payment of interest on or principal of any Notes because of the reinstatement of its obligations, the Company shall be
subrogated to the rights of the Holders of such Notes to receive such payment from the money held by the Trustee or Paying Agent.

 

Article
9

Amendments

 

Article VIII of the Base Indenture is hereby replaced in
full, solely with respect to the Notes, with the following:

 

Section
9.01.        Without
Consent of Holders. The Company and the Trustee may amend the Indenture or the Notes without notice to or consent of any Holder:

 

(a)           
to provide for conversion rights of Holders and the Company’s repurchase obligations in connection with a Fundamental
Change in the event of any reclassification of the Common Stock, merger or consolidation, or sale, conveyance, transfer, lease
or other disposition of all or substantially all of the property and assets of the Company and its Subsidiaries taken as a whole;

 

(b)          
to secure the Notes;

 

(c)          
to provide for the assumption of the Company’s obligations to the Holders in the event of a merger or consolidation,
or sale, conveyance, transfer, lease or other disposition of all or substantially all of the property and assets of the Company
and its Subsidiaries taken as a whole;

 

(d)          
to surrender any right or power conferred upon the Company;

 

(e)          
to add to the Company’s covenants for the benefit of the Holders;

 

(f)           
enter into any supplemental indenture pursuant to Section 5.02;

 

(g)           to
cure any ambiguity or correct or supplement any inconsistent or otherwise defective provision or omission contained in the
Indenture; provided that such modification or amendment does not, in the good faith determination of the Board of
Directors, adversely affect the interests of the Holders in any material respect; provided, further, that any
amendment, supplement or other modification made to conform the provisions of the Indenture to the description of the Notes
contained in the Preliminary Prospectus Supplement as supplemented by the related pricing term sheet shall not be deemed to
adversely affect the interests of the Holders;

 

    - 32 -

     

    

 

 

(h)               
in connection with any share exchange event, provide that the Notes are convertible into Reference Property, subject
to Section 10.02, and make certain related changes to the terms of the Notes to the extent expressly required by the Indenture
(as determined in good faith by the Board of Directors);

 

(i)                
to increase the Conversion Rate;

 

(j)                
to comply with the requirements of the SEC in order to effect or maintain the qualification of the Indenture under
the Trust Indenture Act;

 

(k)               
to comply with the rules of any applicable securities depositary, including the Depositary;

 

(l)                
to permit or confirm for the issuance of Additional Notes in accordance with the Indenture;

 

(m)              
to add guarantees of obligations under the Notes;

 

(n)              
adding or modifying any other provision(s) or omission(s) which the Company may deem necessary or desirable and which
will not adversely affect the interests of the Holders in any material respect, in the good faith determination of the Board of
Directors; and

 

(o)              
to evidence or provide for a successor Trustee, including the appointment thereof.

 

After a modification or amendment under this
Section becomes effective, the Company shall transmit to Holders a notice briefly describing such modification or amendment. However,
the failure to give such notice to all Holders, or any defect in the notice, shall not impair or affect the validity of the modification
or amendment under this Section.

 

Section
9.02.        With
Consent of Holders. The Company and the Trustee may modify or amend the Indenture or the Notes with the written consent or
affirmative vote (including, without limitation, consents obtained in connection with a purchase of, or tender offer or exchange
offer for, Notes) of the Holders of a majority in aggregate principal amount of the Notes then outstanding, without notice to any
other Holder. However, without the written consent or the affirmative vote (including, without limitation, consents obtained in
connection with a purchase of, or tender offer or exchange offer for, Notes) of each Holder of an outstanding Note affected by
such change, an amendment may not:

 

(a)              
change the Maturity Date of any Note;

 

    - 33 -

     

    

 

(b)              
reduce the rate or extend the time for payment of interest on any Notes;

 

(c)              
reduce the principal amount of any Notes;

 

(d)              
reduce any amount payable upon repurchase of any Notes upon a Fundamental Change;

 

(e)              
impair the right of any Holder to receive payment of principal (including the Fundamental Change Repurchase Price,
if applicable) of, accrued and unpaid interest, if any, on, and the consideration due upon conversion of, its Notes on or after
the respective due dates expressed or provided for in the Indenture or to institute suit for the enforcement of any such payment;

 

(f)               
change the currency in which any Notes is payable;

 

(g)              
change the Company’s obligation to repurchase any Notes upon a Fundamental Change in a manner adverse to the
Holders;

 

(h)              
make any change in Section 2.07;

 

(i)               
adversely affect the conversion right of a Holder to convert its Notes pursuant to the terms of the Indenture;

 

(j)                
make any change in Section 6.04 or the second sentence of this Section 9.02; or

 

It shall not be necessary for the consent
of the Holders under this Section to approve the particular form of any proposed modification or amendment. It is sufficient if
such consent approves the substance of the proposed modification or amendment.

 

After a modification or amendment under this
Section becomes effective, the Company shall transmit to Holders a notice briefly describing such modification or amendment. However,
the failure to give such notice to all Holders, or any defect in the notice, shall not impair or affect the validity of the modification
or amendment under this Section.

 

Section
9.03.        Revocation
and Effect of Consents and Waivers. A consent to an amendment or a waiver by a Holder shall bind the Holder and every subsequent
Holder of that Note or portion of the Note that evidences the same debt as the consenting Holder’s Note, even if notation
of the consent or waiver is not made on the Note. However, any such Holder or subsequent Holder may revoke the consent or waiver
as to such Holder’s Note or portion of the Note if the Trustee receives the notice of revocation before the date the amendment
or waiver becomes effective. An amendment or waiver becomes effective once both (i) the requisite number of consents have been
received by the Company or the Trustee and (ii) such amendment or waiver has been executed by the Company and the Trustee.

 

The Company may, but shall not be
obligated to, fix a record date for the purpose of determining the Holders entitled to give their consent or take any other
action described above or required or permitted to be taken pursuant to the Indenture. If a record date is fixed, then
notwithstanding the immediately preceding paragraph, those Persons who were Holders at such record date (or their duly
designated proxies), and only those Persons, shall be entitled to give such consent or to revoke any consent previously given
or to take any such action, whether or not such Persons continue to be Holders after such record date. No such consent shall
be valid or effective for more than 120 calendar days after such record date.

 

    - 34 -

     

    

 

Section
9.04.        Notation
on or Exchange of Notes. If an amendment changes the terms of a Note, the Trustee may require the Holder of the Note to deliver
the Note to the Trustee. The Trustee may place an appropriate notation on the Note regarding the changed terms and return it to
the Holder. Alternatively, if the Company or the Trustee so determines, the Company in exchange for the Note shall issue and the
Trustee shall authenticate a new Note that reflects the changed terms. Failure to make the appropriate notation or to issue a new
Note shall not affect the validity of such amendment.

 

Section
9.05.        Trustee
to Sign Amendments. The Trustee shall sign any amendment authorized pursuant to this Article 9 if the amendment does not adversely
affect the rights, duties, liabilities or immunities of the Trustee. If it does, the Trustee may but need not sign it. In signing
such amendment the Trustee shall be entitled to receive, and (subject to Sections 7.01 and 7.02) shall be fully protected in relying
upon, in addition to the documents required by Section 1.2 of the Base Indenture, an Officer’s Certificate and an Opinion
of Counsel stating that such amendment is authorized or permitted by the Indenture and that such amendment is the legal, valid
and binding obligation of the Company enforceable against it in accordance with its terms, subject to customary exceptions, and
complies with the provisions hereof.

 

Article
10

 

Conversion of Notes

 

Section
10.01.    Right to Convert.

 

(a)              
Subject to and upon compliance with the provisions of this Article 10, each Holder of a Note shall have the right,
at such Holder’s option, to convert all or any portion (if the portion to be converted is $1,000 principal amount or an integral
multiple in excess thereof) of such Note (i) subject to satisfaction of one or more of the conditions described in Section 10.01(b),
at any time prior to the Close of Business on the Business Day immediately preceding September 1, 2027 and (ii) regardless of the
conditions described in Section 10.01(b), on or after September 1, 2027 and prior to the Close of Business on the second Scheduled
Trading Day immediately preceding the Maturity Date, in each case, at the Conversion Rate per $1,000 principal amount of Notes
(subject to, and in accordance with, the settlement provisions of Section 10.02, the “Conversion Obligation”).

 

(b)               (1)Conversion
Upon Satisfaction of Sale Price Condition. Prior to the Close of Business on the Business Day immediately preceding
September 1, 2027, a Holder shall have the right to convert all or a portion of its Notes at any time during any calendar
quarter (and only during such calendar quarter) beginning after March 31, 2020 if the Closing Sale Price for the Common Stock
was more than 130% of the applicable Conversion Price on each applicable Trading Day for at least 20 Trading Days (whether or
not consecutive) in the period of the 30 consecutive Trading Days ending on the last Trading Day of the immediately preceding
calendar quarter.

 

    - 35 -

     

    

 

(2)       Conversion
Upon Specified Corporate Transactions. Prior to the Close of Business on the Business Day immediately preceding September 1,
2027, a Holder shall have the right to convert all or a portion of its Notes if the Company:

 

(i)              
distributes to all or substantially all holders of its Common Stock rights, options or warrants (other than pursuant
to a stockholders rights plan) entitling them to purchase, for a period of 45 calendar days or less from the announcement date
for such distribution, shares of Common Stock at a price per share less than the average of the Closing Sale Prices of the Common
Stock for the ten consecutive Trading Day period ending on, and including, the Trading Day immediately preceding the announcement
date for such distribution; or

 

(ii)             
distributes to all or substantially all holders of its Common Stock cash or other assets, debt securities or rights
to purchase securities of the Company (other than pursuant to a stockholders rights plan), which distribution has a per share value,
as reasonably determined by the Board of Directors, exceeding 10% of the Closing Sale Price of the Common Stock on the Trading
Day immediately preceding the announcement date for such distribution,

 

then, in each case, the Company shall notify all Holders,
the Trustee and the Conversion Agent (if other than the Trustee) at least 45 Scheduled Trading Days prior to the Ex-Dividend Date
for such distribution. Once the Company has given such notice, a Holder may convert all or a portion of its Notes at any time until
the earlier of the Close of Business on the Business Day immediately preceding the Ex-Dividend Date and the Company’s announcement
that such distribution shall not take place. A Holder may not convert any of its Notes based on this Section 10.01(b)(2) if as
a result of holding its Notes such Holder shall otherwise participate in the distribution, without conversion as a result of holding
the Notes, at the same time and on the same terms as holders of the Common Stock as if such Holder held a number of shares of Common
Stock equal to the Conversion Rate on the Record Date of such distribution for each $1,000 principal amount of Notes held by such
Holder (calculated on an aggregate basis per Holder).

 

    - 36 -

     

    

 

(3)       Conversion
Upon a Fundamental Change. Prior to the Close of Business on the Business Day immediately preceding September 1, 2027, if
a Fundamental Change occurs, or if the Company is a party to a consolidation, merger, binding share exchange, or sale,
conveyance, transfer, lease or other disposition of all or substantially all of the Company and its subsidiaries’
assets, taken as a whole, in each case, pursuant to which the Common Stock would be converted into Reference Property in a
transaction described in Section 10.05, a Holder shall have the right to convert all or a portion of its Notes at any time
beginning on the effective date of such transaction or event until the earlier of (x) 35 Trading Days after the actual
effective date of such transaction or event, or if such transaction or event also constitutes a Fundamental Change, until the
related Fundamental Change Repurchase Date and (y) the second Scheduled Trading Day immediately preceding the Maturity Date.
The Company shall notify all Holders, the Trustee and the Conversion Agent (if other than the Trustee) of the effective date
of any Fundamental Change no later than one Business Day after such effective date. If a Holder has submitted all or a
portion of Notes for repurchase, unless such Holder has validly withdrawn such Notes in a timely fashion, such Holder’s
conversion rights with respect to the Notes so subject to repurchase shall expire at the Close of Business on the Business
Day immediately preceding the Fundamental Change Repurchase Date, unless the Company defaults in the payment of the
Fundamental Change Repurchase Price. If a Holder has submitted any Notes for repurchase, such Notes may be converted only if
such Holder submits a valid withdrawal notice, and, if the Notes submitted are evidenced by a Global Note, such Holder
complies with appropriate Depositary procedures.

 

(4)       Conversion
Upon Satisfaction of Trading Price Condition. Prior to the Close of Business on the Business Day immediately preceding September
1, 2027, a Holder shall have a right to convert all or a portion of its Notes during the five Business Day period following any
five consecutive Trading Day period (the “Measurement Period”) in which the Trading Price per $1,000 principal
amount of Notes, as determined following a request by a Holder in accordance with the procedures set forth in this Section 10.01(b)(4),
for each Trading Day of such Measurement Period was less than 98% of the product of the Closing Sale Price of the Common Stock
and the Conversion Rate on such Trading Day. The Bid Solicitation Agent (if other than the Company) shall have no obligation to
determine the Trading Price per $1,000 principal amount of Notes unless the Company has requested such determination; and the Company
shall have no obligation to make such request (or, if the Company is acting as Bid Solicitation Agent, the Company shall have no
obligation to determine the Trading Price) unless and until a Holder provides the Company with reasonable evidence that the Trading
Price per $1,000 principal amount of Notes would be less than 98% of the product of the Closing Sale Price of the Common Stock
and the Conversion Rate and such Holder requests that the Company requests that the Bid Solicitation Agent determine or, if the
Company is acting as Bid Solicitation Agent, requests that the Company determine, the Trading Price of the Notes. At such time,
the Company shall instruct the Bid Solicitation Agent (if other than the Company) to determine or, if the Company is acting as
Bid Solicitation Agent, the Company shall determine, the Trading Price of the Notes for each Trading Day beginning on the next
Trading Day and on each successive Trading Day until a Trading Day occurs on which the Trading Price per $1,000 principal amount
of Notes is greater than or equal to 98% of the product of the Closing Sale Price of the Common Stock and the applicable Conversion
Rate on such Trading Day. At such time as the Company directs the Bid Solicitation Agent in writing to solicit bid quotations,
the Company shall provide the Bid Solicitation Agent with the names and contact details of the three independent nationally recognized
securities dealers the Company selects, and the Company shall direct those securities dealers to provide bids to the Bid Solicitation
Agent. If the Trading Price condition has been met, the Company shall so notify the Holders, the Trustee and the Conversion Agent
(if other than the Trustee). If, at any time after the Trading Price condition has been met, the Trading Price per $1,000 principal
amount of Notes is greater than or equal to 98% of the product of the Closing Sale Price of the Common Stock and the Conversion
Rate for such date, the Company shall so promptly notify the Holders, the Trustee and the Conversion Agent (if other than the Trustee).

 

    - 37 -

     

    

 

Section
10.02.     Conversion
Procedures; Settlement Upon Conversion; No Adjustment for Interest or Dividends; Cash Payments in Lieu of Fractional Shares.
(a) In order to exercise the conversion right with respect to any Notes in certificated form, a Holder must:

 

(i)             
complete and manually sign an irrevocable notice of conversion in the form entitled “Form of Conversion Notice”
attached to the reverse of such certificated Note (or a facsimile thereof) (a “Conversion Notice”);

 

(ii)            
deliver such completed Conversion Notice and certificated Note to be converted to the Conversion Agent at the office
of the Conversion Agent;

 

(iii)           
to the extent any shares of Common Stock issuable upon conversion are to be issued in a name other than the Holder’s,
furnish appropriate endorsements and transfer documents as may be required by the Conversion Agent;

 

(iv)           
if required pursuant to Section 10.02(d), pay funds equal to interest payable on the next Interest Payment Date to
which such Holder is not entitled; and

 

(v)            
if required pursuant to Section 10.02(g), pay all transfer or similar taxes, if any.

 

In order to exercise the conversion right
with respect to any interest in a Global Note, a Holder must:

 

(i)             
deliver to the Depositary the appropriate instruction form for conversion pursuant to the Depositary’s conversion
program;

 

(ii)            
to the extent any shares of Common Stock issuable upon conversion are to be issued in a name other than the Holder’s,
furnish appropriate endorsements and transfer documents as may be required by the Conversion Agent;

 

(iii)           
if required pursuant to Section 10.02(d), pay funds equal to interest payable on the next Interest Payment Date to
which such Holder is not entitled; and

 

(iv)           
if required pursuant to Section 10.02(g), pay all transfer or similar taxes, if any.

 

The date that the Holder satisfies the foregoing
requirements is the “Conversion Date.” The Notes shall be deemed to have been converted immediately prior to
the Close of Business on the Conversion Date.

 

(b)              
Subject to this Section 10.02, upon conversion of any Note, the Company shall, at its election, pay or deliver, as
the case may be, to the converting Holder, in full satisfaction of its Conversion Obligation, cash (“Cash Settlement”),
shares of Common Stock (“Physical Settlement”) or a combination of cash and shares of Common Stock (“Combination
Settlement”), as set forth in this Section 10.02.

 

    - 38 -

     

    

 

(i)             
All conversions occurring on or after September 1, 2027 shall be settled using the same Settlement Method and the
same relative proportion of cash and/or shares of Common Stock as all other conversions occurring on or after September 1, 2027.
If the Company elects a Settlement Method for conversions occurring on or after September 1, 2027, the Company shall deliver notice
to Holders, the Trustee and the Conversion Agent (if other than the Trustee) of such Settlement Method the Company has selected
no later than September 1, 2027. If the Company does not timely elect a Settlement Method for conversion occurring on or after
September 1, 2027, the Company shall no longer have the right to elect Cash Settlement or Physical Settlement with respect to that
Conversion Date and the Company shall be deemed to have elected Combination Settlement in respect of its Conversion Obligation,
and the Specified Dollar Amount per $1,000 principal amount of Notes shall be equal to $1,000. If the Company has timely elected
Combination Settlement in respect of any such conversion, but fails to timely notify the Conversion Agent of the Specified Dollar
Amount per $1,000 principal amount of Notes, such Specified Dollar Amount with respect to that Conversion Date shall be deemed
to be $1,000.

 

(ii)            
With respect to conversions occurring prior to September 1, 2027, the Company shall use the same Settlement Method
(including the same relative proportion of cash and/or shares of Common Stock) for all conversions occurring on the same Conversion
Date. Except for any conversions that occur on or after September 1, 2027, the Company shall not have any obligation to use the
same Settlement Method with respect to conversions that occur on different Conversion Dates. Prior to September 1, 2027, if the
Company elects a Settlement Method, the Company shall deliver notice to converting Holders, the Trustee and the Conversion Agent
(if other than the Trustee) of such Settlement Method the Company has selected no later than the Close of Business on the second
Trading Day immediately following the relevant Conversion Date. If the Company does not timely elect a Settlement Method in respect
of a particular Conversion Date, the Company shall no longer have the right to elect Cash Settlement or Physical Settlement with
respect to that Conversion Date and the Company shall be deemed to have elected Combination Settlement in respect of its Conversion
Obligation, and the Specified Dollar Amount per $1,000 principal amount of Notes shall be equal to $1,000. If the Company has timely
elected Combination Settlement in respect of any such conversion, but fails to timely notify the Conversion Agent of the Specified
Dollar Amount per $1,000 principal amount of Notes, such Specified Dollar Amount with respect to that Conversion Date shall be
deemed to be $1,000.

 

(iii)           
The cash, shares of Common Stock or combination of cash and shares of Common Stock payable or deliverable by the
Company in respect of any conversion of Notes (the “Settlement Amount”) shall be computed by the Company as
follows:

 

(A)             if
the Company elects to satisfy its Conversion Obligation in respect of such conversion by Physical Settlement, the Company
shall deliver to the converting Holder in respect of each $1,000 principal amount of Notes being converted a number of shares
of Common Stock equal to the Conversion Rate on the Conversion Date (plus cash in lieu of any fractional share of Common
Stock issuable upon conversion);

 

    - 39 -

     

    

 

(B)             
if the Company elects to satisfy its Conversion Obligation in respect of such conversion by Cash Settlement, the
Company shall pay to the converting Holder in respect of each $1,000 principal amount of Notes being converted cash in an amount
equal to the sum of the Daily Conversion Values for each of the 30 consecutive VWAP Trading Days during the relevant Observation
Period; and

 

(C)             
if the Company elects (or is deemed to have elected) to satisfy its Conversion Obligation in respect of such conversion
by Combination Settlement, the Company shall pay and deliver, as the case may be, to the converting Holder in respect of each $1,000
principal amount of Notes being converted a Settlement Amount equal to the sum of the Daily Settlement Amounts for each of the
30 consecutive VWAP Trading Days during the relevant Observation Period (plus cash in lieu of any fractional share of Common Stock
issuable upon conversion).

 

If more than one Note shall be surrendered
for conversion at any one time by the same Holder, the Conversion Obligation with respect to such Notes shall be computed on the
basis of the aggregate principal amount of the Notes (or specified portions thereof to the extent permitted hereby) so surrendered.

 

(iv)           
The Daily Settlement Amounts (if applicable) and the Daily Conversion Values (if applicable) shall be determined
by the Company promptly following the last VWAP Trading Day of the relevant Observation Period. Promptly after such determination
of the Daily Settlement Amounts or the Daily Conversion Values, as the case may be, and, if applicable, the amount of cash payable
in lieu of any fractional share, the Company shall notify the Trustee and the Conversion Agent (if other than the Trustee) of the
Daily Settlement Amounts or the Daily Conversion Values, as the case may be, and, if applicable, the amount of cash payable in
lieu of fractional shares of Common Stock. The Trustee and the Conversion Agent (if other than the Trustee) shall have no responsibility
for any such determination.

 

(v)            
Subject to the provisions of Section 10.03 and Section 10.05, the Company shall pay or deliver, as the case may be,
the Settlement Amount due in respect of the Conversion Obligation as follows:

 

(A)            
if the Company elects Physical Settlement, (x) with respect to conversions occurring prior to the final Regular Record
Date preceding the Maturity Date, the third Business Day immediately following the relevant Conversion Date and (y) with respect
to conversions occurring on or after the final Regular Record Date preceding the Maturity Date, on the Maturity Date; or

 

(B)             
if the Company elects Cash Settlement or if the Company elects or is deemed to elect Combination Settlement, the
third Business Day immediately following the last VWAP Trading Day of the relevant Observation Period.

 

    - 40 -

     

    

 

(c)              
Each conversion will be deemed to have been effected as to any Notes surrendered for conversion on the applicable
Conversion Date; provided, however, that the Person in whose name any shares of Common Stock shall be issuable upon
such conversion shall be treated as the holder of record of such shares as of the Close of Business on the Conversion Date, in
the case of Physical Settlement, or the last VWAP Trading Day of the relevant Observation Period, in the case of Combination Settlement.

 

(d)              
If a Holder converts any Notes after the Close of Business on the Regular Record Date for an interest payment but
prior to the corresponding Interest Payment Date, such Holder shall receive on the earlier of the corresponding Interest Payment
Date and the date the Company delivers the Settlement Amount in respect of such conversion, the interest accrued and unpaid on
such Holder’s Notes, notwithstanding such Holder’s conversion of those Notes prior to the Interest Payment Date, in
the event that such Holder was the Holder of record on the corresponding Regular Record Date. However, except as provided in the
next sentence, at the time such Holder surrenders its Notes for conversion (whether or not such Holder was the Holder of record),
such Holder must pay the Company an amount equal to the interest that has accrued and shall be paid on the Notes being converted
on the corresponding Interest Payment Date. Such Holder is not required to make such payment:

 

(1)       if
such Holder converts its Notes after the Close of Business on February 15, 2028, which is the Regular Record Date immediately preceding
the Maturity Date;

 

(2)       if
such Holder converts its Notes in connection with a Fundamental Change and the Company has specified a Fundamental Change Repurchase
Date that is after a Regular Record Date and on or prior to the Business Day immediately following the corresponding Interest Payment
Date; or

 

(3)       to
the extent of any overdue interest, if overdue interest exists at the time of conversion with respect to such Holder’s Notes.

 

For the avoidance of doubt, all Holders on
the Regular Record Date immediately preceding the Maturity Date and any Fundamental Change Repurchase Date shall receive and retain
the full interest payment due on the Maturity Date or other applicable Interest Payment Date regardless of whether their Notes
have been converted following such Regular Record Date.

 

If a Holder has already delivered a Fundamental
Change Repurchase Notice pursuant to Section 3.01 with respect to a Note, such Holder may not surrender that Note for conversion
until such Holder has validly withdrawn the Fundamental Change Repurchase Notice in accordance with Section 3.02, except as to
a portion of such Note that is not subject to such Fundamental Change Repurchase Notice.

 

(e)               In
case any certificated Note shall be surrendered for partial conversion, the Company shall execute and the Trustee shall
authenticate and deliver to or upon the written order of the Holder of the certificated Note so surrendered, without charge
to such Holder, a new certificated Note or Notes in authorized denominations in an aggregate principal amount equal to the
unconverted portion of the surrendered certificated Note.

 

    - 41 -

     

    

 

(f)               
Upon the conversion of an interest in a Global Note, the Trustee and the Depositary shall reduce the principal amount
of such Global Note in their records.

 

(g)              
The issue of stock certificates on conversions of Notes shall be made without charge to the converting holder of
Notes for any taxes or duties in respect of the issue thereof. The Company shall not, however, be required to pay any such tax
or duty which may be payable in respect of any transfer involved in the issue and delivery of stock in any name other than that
of the holder of any Notes converted, and the Company shall not be required to issue or deliver any such stock certificate unless
and until the Person or Persons requesting the issue thereof shall have paid to the Company the amount of such tax or duty or shall
have established to the satisfaction of the Company that such tax has been paid.

 

(h)              
Except as provided in this Section 10.02, upon conversion, Holders shall not receive any separate cash payment of
accrued and unpaid interest on the Notes. Accrued and unpaid interest to the Conversion Date shall be deemed to be paid in full
with the cash paid and shares of Common Stock issued, if any, upon conversion rather than cancelled, extinguished or forfeited.
With respect to Notes converted pursuant to Combination Settlement, accrued and unpaid interest shall be deemed to be paid first
out of any cash paid upon such conversion.

 

(i)                
The Company shall not issue fractional shares of Common Stock upon conversion of the Notes. If any fractional shares
of Common Stock would be issuable upon the conversion of any Note or Notes, the Company shall instead pay cash in lieu of fractional
share of Common Stock issuable upon conversion in an amount based on (i) the Daily VWAP on the relevant Conversion Date if the
Company elects Physical Settlement or (ii) the Daily VWAP on the last VWAP Trading Day of the relevant Observation Period if the
Company elects or is deemed to elect Combination Settlement.

 

(j)                
Except as described under Section 10.04, the Company shall not make any payment or other adjustment for dividends
on any Common Stock issued upon conversion of the Notes.

 

(k)              
The Trustee shall have no duty to monitor or notify the Holders as to whether any of the conditions to conversion
have occurred.

 

Section
10.03.    Adjustment
to Conversion Rate Upon a Make-Whole Fundamental Change. If the Effective Date (as defined below) of a Fundamental Change (determined
after giving effect to any exceptions to or exclusions from such definition, but without regard to the proviso in clause
(2) of the definition thereof, a “Make-Whole Fundamental Change”) occurs prior to the Maturity Date of the Notes
and a Holder elects to convert its Notes in connection with such Make-Whole Fundamental Change, the Company shall increase the
Conversion Rate by an additional number of shares of Common Stock (the “Additional Shares”).

 

The number of Additional Shares shall be
determined by reference to the table below, based on the date on which the Make-Whole Fundamental Change becomes effective
(the “Effective Date”) and the Stock Price paid (or deemed paid) per share for the Common Stock in such
Make-Whole Fundamental Change.

 

    - 42 -

     

    

 

The Company shall notify the Holders, the
Trustee and the Conversion Agent (if other than the Trustee) of the Effective Date of any Make-Whole Fundamental Change no later
than one Business Day after such Effective Date.

 

A conversion of the Notes shall be deemed
for these purposes to be “in connection with” a Make-Whole Fundamental Change if the Conversion Notice is received
by the Conversion Agent on or after the Effective Date of the Make-Whole Fundamental Change but before the Close of Business on
the second Business Day immediately preceding the related Fundamental Change Repurchase Date (or, in the case of a Make-Whole Fundamental
Change that would have been a Fundamental Change but for the proviso in clause (2) of the definition thereof, the 35th
Trading Day immediately following the Effective Date of such Make-Whole Fundamental Change).

 

The number of Additional Shares set forth
in the table below shall be adjusted in the same manner as and as of any date on which the Conversion Rate of the Notes is adjusted
pursuant to this Article 10. The Stock Prices set forth in the first row of the table below (i.e., the column headers)
shall be simultaneously adjusted to equal the Stock Prices immediately prior to such adjustment, multiplied by
a fraction, the numerator of which shall be the Conversion Rate immediately prior to the adjustment and the denominator of
which shall be the Conversion Rate as so adjusted.

 

The following table sets forth the number
of Additional Shares per $1,000 principal amount of Notes by which the Conversion Rate shall be increased upon conversion in connection
with a Make-Whole Fundamental Change:

 

	 	 	Stock
    Price	 
	Effective
    date	 	$95.56	 	 	$100.00	 	 	$110.00	 	 	$121.84	 	 	$135.00	 	 	$150.00	 	 	$175.00	 	 	$200.00	 	 	$225.00	 	 	$250.00	 	 	$300.00	 	 	$350.00	 	 	$450.00	 
	February 27, 2020	 	 	2.2570	 	 	 	2.2544	 	 	 	1.8720	 	 	 	1.4897	 	 	 	1.1699	 	 	 	0.8993	 	 	 	0.5923	 	 	 	0.3964	 	 	 	0.2670	 	 	 	0.1794	 	 	 	0.0772	 	 	 	0.0282	 	 	 	0.0000	 
	March 1, 2021	 	 	2.2570	 	 	 	2.2521	 	 	 	1.8610	 	 	 	1.4767	 	 	 	1.1607	 	 	 	0.8838	 	 	 	0.5728	 	 	 	0.3771	 	 	 	0.2496	 	 	 	0.1645	 	 	 	0.0675	 	 	 	0.0228	 	 	 	0.0000	 
	March 1, 2022	 	 	2.2570	 	 	 	2.2484	 	 	 	1.8520	 	 	 	1.4658	 	 	 	1.1287	 	 	 	0.8481	 	 	 	0.5375	 	 	 	0.3457	 	 	 	0.2230	 	 	 	0.1429	 	 	 	0.0543	 	 	 	0.0158	 	 	 	0.0000	 
	March 1, 2023	 	 	2.2570	 	 	 	2.2421	 	 	 	1.8441	 	 	 	1.4229	 	 	 	1.0791	 	 	 	0.7965	 	 	 	0.4895	 	 	 	0.3047	 	 	 	0.1898	 	 	 	0.1167	 	 	 	0.0395	 	 	 	0.0088	 	 	 	0.0000	 
	March 1, 2024	 	 	2.2570	 	 	 	2.2310	 	 	 	1.7913	 	 	 	1.3565	 	 	 	1.0065	 	 	 	0.7242	 	 	 	0.4258	 	 	 	0.2529	 	 	 	0.1496	 	 	 	0.0866	 	 	 	0.0245	 	 	 	0.0033	 	 	 	0.0000	 
	March 1, 2025	 	 	2.2570	 	 	 	2.2275	 	 	 	1.7083	 	 	 	1.2580	 	 	 	0.9034	 	 	 	0.6251	 	 	 	0.3433	 	 	 	0.1894	 	 	 	0.1029	 	 	 	0.0537	 	 	 	0.0104	 	 	 	0.0001	 	 	 	0.0000	 
	March 1, 2026	 	 	2.2570	 	 	 	2.1294	 	 	 	1.5745	 	 	 	1.1052	 	 	 	0.7494	 	 	 	0.4840	 	 	 	0.2356	 	 	 	0.1138	 	 	 	0.0528	 	 	 	0.0220	 	 	 	0.0011	 	 	 	0.0000	 	 	 	0.0000	 
	March 1, 2027	 	 	2.2570	 	 	 	1.9666	 	 	 	1.3432	 	 	 	0.8425	 	 	 	0.4976	 	 	 	0.2734	 	 	 	0.1014	 	 	 	0.0360	 	 	 	0.0105	 	 	 	0.0015	 	 	 	0.0000	 	 	 	0.0000	 	 	 	0.0000	 
	March 1, 2028	 	 	2.2570	 	 	 	1.7924	 	 	 	0.8833	 	 	 	0.0000	 	 	 	0.0000	 	 	 	0.0000	 	 	 	0.0000	 	 	 	0.0000	 	 	 	0.0000	 	 	 	0.0000	 	 	 	0.0000	 	 	 	0.0000	 	 	 	0.0000	 

 

 

provided, however, that:

 

(1)       if
the exact Stock Price is between two Stock Prices listed in the table above under the column titled “Stock Price,”
or if the exact Effective Date of such Make-Whole Fundamental Change is between two Effective Dates listed in the table above in
the rows immediately below the title “Effective Date,” then the number of Additional Shares by which the Conversion
Rate shall be increased shall be determined by a straight-line interpolation between the number of Additional Shares set forth
for the higher and lower Stock Prices and the earlier and later Effective Dates based on a 360-day year; and

 

    - 43 -

     

    

 

(2)       (a)
if the exact Stock Price is greater than $450.00 per share (subject to adjustment in the same manner and at the same time as the
Stock Prices listed in the table above), then the Conversion Rate shall not be increased, or (b) if the exact Stock Price is less
than $95.56 per share (subject to adjustment in the same manner and at the same time as the Stock Prices listed in the table above),
then the Conversion Rate shall not be increased.

 

Notwithstanding the foregoing, in no event
shall the total number of shares of Common Stock issuable upon conversion exceed 10.4646 shares per $1,000 principal amount of
Notes, subject to adjustment in the same manner and at the same time as the Conversion Rate pursuant to this Article 10.

 

Section
10.04.    Adjustment
of Conversion Rate. The Conversion Rate shall be adjusted from time to time by the Company if any of the following events occurs,
except that the Company shall not make any adjustments to the Conversion Rate if Holders participate (other than in the case of
a share split or a share combination), at the same time and upon the same terms as holders of the Common Stock and solely as a
result of holding the Notes, in any of the transactions described in this Section 10.04, without having to convert their Notes,
as if they held a number of shares of Common Stock equal to the applicable Conversion Rate for each $1,000 principal amount of
Notes held by such Holders (calculated on an aggregate basis per Holder):

 

(a)              
If the Company shall issue shares of Common Stock to all or substantially all holders of Common Stock as a dividend
or distribution on shares of Common Stock, or if the Company effects a share split or share combination, the Conversion Rate shall
be adjusted based on the following formula:

 

 

where,

 

		CR =	the Conversion Rate in effect immediately after the Open of Business on the Ex-Dividend Date for such dividend or distribution,
or the Effective Date of such share split or share combination, as the case may be;

 

		CR0 =	the Conversion Rate in effect immediately
prior to the Open of Business on the Ex-Dividend Date for such dividend or distribution or the Effective Date of such share split
or share combination, as the case may be;

 

		OS0 =	the number of shares of Common Stock outstanding
immediately prior to the Open of Business on the Ex-Dividend Date for such dividend or distribution or the Effective Date of such
share split or share combination, as the case may be; and

 

		OS =	the number of shares of Common Stock that would be outstanding immediately after, and solely as a result of, such dividend,
distribution, share split or share combination, as the case may be.

 

    - 44 -

     

    

 

Any adjustment made under this clause (a)
shall become effective immediately after the Open of Business on the Ex-Dividend Date for such dividend or distribution, or immediately
after the Open of Business on the Effective Date for such share split or share combination, as applicable. If any dividend or distribution
of the type described in this clause (a) is declared but not so paid or made, the Conversion Rate shall be immediately readjusted,
effective as the date the Board of Directors determines not to pay such dividend or distribution, to the Conversion Rate that would
then be in effect if such dividend or distribution had not been declared.

 

(b)              
If the Company shall issue to all or substantially all holders of its Common Stock any rights, options or warrants
(other than pursuant to a stockholders rights plan) entitling them to purchase, for a period of 45 calendar days or less from the
announcement date for such distribution, shares of Common Stock at a price per share that is less than the average of the Closing
Sale Price of the Common Stock for the ten consecutive Trading Day period ending on, and including, the Trading Day immediately
preceding the announcement date for such issuance, the Conversion Rate shall be increased based on the following formula:

 

 

where,

 

		CR =	the Conversion Rate in effect immediately after the Open of Business on the Ex-Dividend Date for such issuance;

 

		CR0 =	the Conversion Rate in effect immediately prior to the
Open of Business on such Ex-Dividend Date for such issuance;

 

		OS0 =	the number of shares of Common Stock outstanding immediately
prior to the Open of Business on such Ex-Dividend Date for such issuance;

 

		X =	the total number of shares of Common Stock issuable pursuant to such rights, options or warrants; and

 

		Y =	the number of shares of Common Stock equal to the aggregate price payable to exercise such rights, options or warrants, divided
by the average of the Closing Sale Prices of the Common Stock over the ten consecutive Trading Day period ending on, and including,
the Trading Day immediately preceding the Ex-Dividend Date for such issuance.

 

Any increase made under this clause (b)
shall be made successively whenever any such rights, options or warrants are issued and shall become effective immediately
after the Open of Business on the Ex-Dividend Date for such issuance. To the extent that such rights, options or warrants are
not exercised prior to their expiration or shares of Common Stock are not delivered upon exercise of such rights, options or
warrants, the Conversion Rate shall be readjusted to the Conversion Rate that would then be in effect had the increase with
respect to the issuance of such rights, options or warrants been made on the basis of delivery of only the number of shares
of Common Stock actually delivered. If such rights, options or warrants are not so issued, or if such rights, options or
warrants are not so exercised prior to their expiration, the Conversion Rate shall be decreased to the Conversion Rate that
would then be in effect if such Ex-Dividend Date for such issuance had not occurred.

 

    - 45 -

     

    

 

In determining whether any rights, options
or warrants entitle the holders of Common Stock to subscribe for or purchase shares of Common Stock at less than such average of
the Closing Sale Prices for the ten consecutive Trading Day period ending on, and including, the Trading Day immediately preceding
the announcement date for such issuance, and in determining the aggregate offering price of such shares of Common Stock, there
shall be taken into account any consideration received by the Company for such rights, options or warrants and any amount payable
on exercise or conversion thereof and the value of such consideration (if other than cash, to be determined by the Board of Directors).

 

(c)              
If the Company distributes shares of its Capital Stock, evidences of its indebtedness, other of its assets or property
or rights, options or warrants to acquire its Capital Stock or other securities to all or substantially all holders of Common Stock,
excluding:

 

(i)             
dividends, distributions or issuances as to which an adjustment was effected pursuant to clause (a) or (b) above;

 

(ii)            
rights issued under a stockholders rights plan;

 

(iii)           
dividends or distributions paid exclusively in cash as to which the provisions set forth in clause (d) below shall
apply;

 

(iv)           
distributions of Reference Property in a transaction described in Section 10.05; and

 

(v)            
Spin-Offs described below in the second paragraph of this clause (c),

 

then the Conversion Rate shall be increased based on the following
formula:

 

 

where,

 

		CR =	the Conversion Rate in effect immediately after the Open of Business on the Ex-Dividend Date for such distribution;

 

		CR0 =	the Conversion Rate in effect immediately prior to the
Open of Business on such Ex-Dividend Date for such distribution;

 

		SP0 =	the average of the Closing Sale Prices of the Common
Stock over the ten consecutive Trading Day period ending on, and including, the Trading Day immediately preceding the Ex-Dividend Date for
such distribution; and

 

    - 46 -

     

    

 

		FMV =	the Fair Market Value (as determined by the Board of Directors) of the shares of Capital Stock, evidences of indebtedness,
assets, property, rights, options or warrants distributed with respect to each outstanding share of the Common Stock on the Ex-Dividend
Date for such distribution.

 

Any increase made under the portion of this
clause (c) above shall become effective immediately after the Open of Business on the Ex-Dividend Date for such distribution. If
such distribution is not so paid or made, the Conversion Rate shall be decreased to be the Conversion Rate that would then be in
effect if such distribution had not been declared.

 

Notwithstanding the foregoing, if “FMV”
(as defined above) is equal to or greater than “SP0” (as defined above), in lieu of the foregoing increase,
each Holder shall receive, in respect of each $1,000 principal amount thereof, at the same time and upon the same terms as holders
of the Common Stock, the amount and kind of the Company’s Capital Stock, evidences of the Company’s indebtedness, other
assets or property of the Company or rights, options or warrants to acquire the Company’s Capital Stock or other securities
that such Holder would have received if such Holder owned a number of shares of Common Stock equal to the Conversion Rate in effect
on the Ex-Dividend Date for the distribution.

 

With respect to an adjustment pursuant to
this clause (c) where there has been a payment of a dividend or other distribution on the Common Stock in shares of Capital Stock
of any class or series, or similar equity interest, of or relating to a Subsidiary or other business unit that are, or when issued
shall be, listed or admitted for trading on a U.S. national securities exchange (a “Spin-Off”) the Conversion
Rate shall be increased based on the following formula:

 

 

where,

 

		CR =	the Conversion Rate in effect immediately after the Open of Business on the Ex-Dividend Date for the Spin-Off;

 

		CR0 =	the Conversion Rate in effect immediately prior to the
Open of Business on the Ex-Dividend Date for the Spin-Off;

 

		FMV =	the average of the Closing Sale Prices of the Capital Stock or similar equity interest distributed to holders of the Common
Stock applicable to one share of the Common Stock over the first ten consecutive Trading Day period immediately following, and
including, the Ex-Dividend Date of the Spin-Off (such period, the “Valuation Period”); and

 

		MP0 =	the average of the Closing Sale Prices of the Common
Stock over the Valuation Period.

 

    - 47 -

     

    

 

Any adjustment to the Conversion Rate under
the preceding paragraph of this clause (c) shall be made immediately after the Open of Business on the day after the last day of
the Valuation Period, but shall be given effect as of the Open of Business on the Ex-Dividend Date for the Spin-Off. Notwithstanding
anything to the contrary, (i) if the settlement date for a Note whose conversion is to be settled pursuant to Cash Settlement or
Combination Settlement occurs on or before the last Trading Day in the Valuation Period for any Spin-Off and any VWAP Trading Day
in the Observation Period for such conversion occurs on any Trading Day within such Valuation Period, then, solely for purposes
of determining the consideration due in respect of such conversion, such Valuation Period shall be deemed to be the period from,
and including, the Ex-Dividend Date for such Spin-Off to, and including, the last VWAP Trading Day in such Observation Period (or,
if such VWAP Trading Day is not a Trading Day, the immediately preceding Trading Day); and (ii) if the settlement date for a Note
whose conversion is to be settled pursuant to Physical Settlement occurs on or before the last Trading Day in the Valuation Period
for a Spin-Off and the Conversion Date for such conversion occurs on any Trading Day within such Valuation Period, then, solely
for purposes of determining the consideration due in respect of such conversion, such Valuation Period shall be deemed to be the
period from, and including, the Ex-Dividend Date for such Spin-Off to, and including, such Conversion Date (or, if such Conversion
Date is not a Trading Day, the immediately preceding Trading Day).

 

For purposes of this Section 10.04(c) and
subject in all respects to Section 10.08, rights, options or warrants distributed by the Company to all or substantially all holders
of its Common Stock entitling the holders thereof to subscribe for or purchase shares of the Company’s Capital Stock, including
Common Stock (either initially or under certain circumstances), which rights, options or warrants, until the occurrence of a specified
event or events (each a “Trigger Event”):

 

(i)             
are deemed to be transferred with such Common Stock;

 

(ii)            
are not exercisable; and

 

(iii)           
are also issued in respect of future issuances of the Common Stock,

 

shall be deemed not to have been distributed for purposes
of this Section 10.04(c) (and no adjustment to the Conversion Rate under this Section 10.04(c) shall be required) until the
occurrence of the earliest Trigger Event, whereupon such rights, options or warrants shall be deemed to have been distributed
and an appropriate adjustment (if any is required) to the Conversion Rate shall be made under this Section 10.04(c). If any
such right, option or warrant, including any such existing rights, options or warrants distributed prior to the date of the
Indenture, are subject to events, upon the occurrence of which such rights, options or warrants become exercisable to
purchase different securities, evidences of indebtedness or other assets, then the date of the occurrence of any and each
such event shall be deemed to be the date of distribution and record date with respect to new rights, options or warrants
with such rights (and a termination or expiration of the existing rights, options or warrants without exercise by any of the
holders thereof). In addition, in the event of any distribution (or deemed distribution) of rights, options or warrants, or
any Trigger Event or other event (of the type described in the preceding sentence) with respect thereto that was counted for
purposes of calculating a distribution amount for which an adjustment to the Conversion Rate under this Section 10.04(c) was
made:

 

    - 48 -

     

    

 

 

 

(1)       in
the case of any such rights, options or warrants that shall all have been redeemed or repurchased without exercise by any holders
thereof, the Conversion Rate shall be readjusted upon such final redemption or repurchase to give effect to such distribution or
Trigger Event, as the case may be, as though it were a cash distribution, equal to the per share redemption or repurchase price
received by a holder or holders of Common Stock with respect to such rights, options or warrants (assuming such holder had retained
such rights, options or warrants), made to all holders of Common Stock as of the date of such redemption or repurchase; and

 

(2)       in
the case of such rights, options or warrants that shall have expired or been terminated without exercise by any holders thereof,
the Conversion Rate shall be readjusted as if such rights, options or warrants had not been issued.

 

(d)      
If the Company pays any cash dividends or distributions paid exclusively in cash to all or substantially all holders
of its Common Stock (other than dividends or distributions made in connection with the Company’s liquidation, dissolution
or winding-up or upon a merger, consolidation or sale, lease, transfer, conveyance or other disposition resulting in a change in
the conversion consideration as described under Section 10.05), the Conversion Rate shall be increased based on the following formula:

 

 

where,

 

		CR
                            =	the
                                         Conversion Rate in effect immediately after the Open of Business on the Ex-Dividend Date
                                         for such dividend or distribution;

 

		CR0
                            =	the
                                         Conversion Rate in effect immediately prior to the Open of Business on the Ex-Dividend
                                         Date for such dividend or distribution;

 

		SP0
                            =	the
                                         average of the Closing Sale Prices of the Common Stock over the ten consecutive Trading
                                         Day period ending on, and including, the Trading Day immediately preceding the Ex-Dividend
                                         Date for such dividend or distribution (or, if the Company declares such dividend or
                                         distribution less than eleven Trading Days prior to such Ex-Dividend Date, ten shall
                                         be replaced with a smaller number of Trading Days that shall have occurred after, and
                                         not including, such declaration date and prior to, but not including, such Ex-Dividend
                                         Date); and

 

		C =	the amount in cash per share the Company distributes to holders of the Common Stock.

 

    - 49 -

     

    

 

Notwithstanding the foregoing, if
 “C” (as defined above) is equal to or greater than “SP0” (as defined above), in lieu of
the foregoing increase, each Holder shall receive, in respect of each $1,000 principal amount thereof, at the same time and
upon the same terms as holders of shares of Common Stock, the amount of cash that such Holder would have received as if such
Holder owned a number of shares of Common Stock equal to the Conversion Rate in effect on the Ex-Dividend Date for such cash
dividend or distribution. To the extent such dividend or distribution is declared but not made or paid, the Conversion Rate
shall be readjusted to the Conversion Rate that would then be in effect had the adjustment been made on the basis of only the
dividend or distribution, if any, actually made or paid.

 

Any increase made under this clause (d) shall
become effective immediately after the Open of Business on the Ex-Dividend Date for such cash dividend or distribution.

 

(e)      
If the Company or any of its Subsidiaries makes a payment in respect of a tender offer or exchange offer for the
Common Stock, to the extent that the cash and value of any other consideration included in the payment per share of the Common
Stock exceeds the Closing Sale Price of the Common Stock on the Trading Day next succeeding the last date on which tenders or exchanges
may be made pursuant to such tender or exchange offer (the “Expiration Date”), the Conversion Rate shall be
increased based on the following formula:

 

 

where,

 

		CR =	the Conversion Rate in effect immediately after the Close of Business on the Trading Day immediately following the Expiration
Date;

 

		CR0
                            =	the
                                         Conversion Rate in effect immediately prior to the Close of Business on the Trading Day
                                         immediately following the Expiration Date;

 

		AC
                            =	the
                                         aggregate value of all cash and any other consideration (as determined by the Board of
                                         Directors) paid or payable for shares purchased in such tender or exchange offer;

 

		SP
                            =	the
                                         average of the Closing Sale Prices of the Common Stock over the ten consecutive Trading
                                         Day period commencing on, and including, the Trading Day next succeeding the Expiration
                                         Date (the “Averaging Period”);

 

		OS
                            =	the
                                         number of shares of Common Stock outstanding immediately after the Close of Business
                                         on the Expiration Date (after giving effect to such tender offer or exchange offer);
                                         and

 

		OS0
                            =	the
                                         number of shares of Common Stock outstanding immediately prior to the Close of Business
                                         on the Expiration Date (prior to giving effect to such tender offer or exchange offer).

 

    - 50 -

     

    

 

Any adjustment to the Conversion Rate under
this clause (e) shall be made immediately prior to the Open of Business on the day following the last day of the Averaging Period,
but shall be given effect as of the Open of Business on the Trading Day immediately following the Expiration Date. Notwithstanding
anything to the contrary, (i) if the settlement date for a Note whose conversion is to be settled pursuant to Cash Settlement
or Combination Settlement occurs on or before the last Trading Day in the Averaging Period for such tender or exchange offer and
any VWAP Trading Day in the Observation Period for such conversion occurs on any Trading Day within such Averaging Period, then,
solely for purposes of determining the consideration due in respect of such conversion, such Averaging Period shall be deemed
to be the period from, and including, the Trading Day immediately after the Expiration Date for such tender or exchange offer
to, and including, the last VWAP Trading Day in such Observation Period (or, if such VWAP Trading Day is not a Trading Day, the
immediately preceding Trading Day); and (ii) if the settlement date for a Note whose conversion is to be settled pursuant to Physical
Settlement occurs on or before the last Trading Day in the Averaging Period for such tender or exchange offer and the Conversion
Date for such conversion occurs on any Trading Day within such Averaging Period, then, solely for purposes of determining the
consideration due in respect of such conversion, such Averaging Period shall be deemed to be the period from, and including, the
Trading Day immediately after the Expiration Date to, and including, such Conversion Date (or, if such Conversion Date is not
a Trading Day, the immediately preceding Trading Day).

 

(f)       
Notwithstanding this Section 10.04, if a Conversion Rate adjustment described in subsections (a) through (e) of this
Section 10.04 becomes effective on any Ex-Dividend Date, and a Holder has converted its Notes on or after such Ex-Dividend Date
and on or prior to the related Record Date and would be treated as the record holder of the shares of Common Stock as of the related
Conversion Date as described under Section 10.02 based on an adjusted Conversion Rate for such Ex-Dividend Date, then, notwithstanding
the foregoing Conversion Rate adjustment provisions, the Conversion Rate adjustment relating to such Ex-Dividend Date shall not
be made for such converting Holder. Instead, such Holder shall be treated as if such Holder were the record owner of such shares
of Common Stock (which shall be calculated on an unadjusted basis) and participate in the related dividend, distribution or other
event giving rise to such adjustment.

 

(g)      
Notwithstanding this Section 10.04, if a Holder converts a Note, Combination Settlement is applicable to such Note
and the Daily Settlement Amount for any VWAP Trading Day during the Observation Period applicable to such Note (x) is calculated
based on a Conversion Rate adjusted on account of any event described in clauses (a) through (e) of this Section 10.04 and (y)
includes any shares of Common Stock that entitle their holder to participate in such event, then, notwithstanding the foregoing
Conversion Rate adjustment provisions in this Section 10.04, such Conversion Rate adjustment shall not be made for such converting
Holder for such Trading Day. Instead, such Holder shall be treated as if such Holder were the record owner of the shares of Common
Stock on an unadjusted basis and participate in the related dividend, distribution or other event giving rise to such adjustment.

 

(h)       To
the extent permitted by applicable law and subject to the applicable rules of the Nasdaq Capital Market, the Company (i) may
increase the Conversion Rate of the Notes by any amount for a period of at least 20 Business Days if the Company determines
that such increase would be in the Company’s best interest and (ii) may (but is not required to) increase the
Conversion Rate of the Notes to avoid or diminish income tax to holders of Common Stock or rights to purchase shares of
Common Stock in connection with a dividend or distribution of shares (or rights to acquire shares) or similar event.

 

    - 51 -

     

    

 

(i)        
All calculations and other determinations under this Article 10 shall be made by the Company and shall be made to
the nearest one-ten thousandth (1/10,000th) of a share. No adjustment pursuant to this Section 10.04 shall be made to the Conversion
Rate unless such adjustment would require a change of at least 1% in the then-effective Conversion Rate. However, any adjustments
that are less than 1% of the Conversion Rate shall be carried forward and taken into account in any subsequent adjustment. Notwithstanding
the foregoing, all such carried-forward adjustments shall be made with respect to the Notes (i) in connection with any subsequent
adjustment to the Conversion Rate of at least 1% and (ii)(a) on each Trading Day of any Observation Period related to the conversion
of the Notes (in the case of Cash Settlement or Combination Settlement) or (b) on the Conversion Date for any Notes (in the case
of Physical Settlement). The deferral provisions described in this Section 10.04(i) is referred to as the “1% Exception.”

 

(j)       
Whenever the Conversion Rate is adjusted as herein provided, the Company shall as soon as reasonably practicable
deliver to the Trustee and the Conversion Agent (if other than the Trustee) an Officer’s Certificate setting forth the Conversion
Rate after such adjustment and setting forth a brief statement of the facts requiring such adjustment. Failure to deliver such
notice shall not affect the legality or validity of any such adjustment. Unless and until a Responsible Officer of the Trustee
shall have received such Officer’s Certificate, the Trustee shall not be deemed to have knowledge of any adjustment of the
Conversion Rate and may assume without inquiry that the last Conversion Rate of which it has knowledge is still in effect. As soon
as reasonably practicable after delivery of such certificate, the Company shall transmit to Holders a notice of such adjustment
of the Conversion Rate setting forth the adjusted Conversion Rate and the date on which such adjustment became effective. Failure
to transmit such notice shall not affect the legality or validity of any such adjustment.

 

(k)      
Except as stated in Section 10.03, this Section 10.04 and Section 10.08, the Company shall not adjust the Conversion
Rate for any transaction or event. Without limiting the foregoing, the Conversion Rate shall not be adjusted:

 

(1)       except
as described in this Section 10.04, upon the sale of shares of Common Stock for a purchase price that is less than the market price
per share of Common Stock or less than the Conversion Price;

 

(2)       upon
the issuance of any shares of Common Stock pursuant to any present or future plan providing for the reinvestment of dividends or
interest payable on the Company’s securities and the investment of additional optional amounts in shares of Common Stock
under any plan;

 

(3)       upon
the issuance of any shares of Common Stock or options or rights to purchase those shares pursuant to any present or future employee,
director or consultant benefit plan or program of or assumed by the Company or any of its Subsidiaries;

 

    - 52 -

     

    

 

(4)       upon
the issuance of any shares of Common Stock pursuant to any option, warrant, right or exercisable, exchangeable or convertible security
not described in clause (3) above and outstanding as of the date the Notes were first issued;

 

(5)       for
the repurchase of any shares of Common Stock that is not a tender offer or exchange offer of the nature described in Section 10.04(e),
including, but not limited to, pursuant to an open-market share repurchase program, a structured or derivative transaction or other
buyback transaction;

 

(6)       solely
for a change in the par value of the Common Stock; or

 

(7)       for
accrued and unpaid interest, if any.

 

(l)       
For purposes of this Section 10.04, the number of shares of Common Stock at any time outstanding shall not include
shares held in the treasury of the Company but shall include shares issuable in respect of scrip certificates issued in lieu of
fractions of shares of Common Stock. The Company shall not pay any dividend or make any distribution on shares of Common Stock
held in the treasury of the Company.

 

(m)      
Whenever any provision of this Article 10 requires the Company to calculate the Closing Sale Prices, the Daily VWAPs,
the Daily Conversion Values or the Daily Settlement Amounts over, or based on, a span of multiple days (including an Observation
Period and the “Stock Price” for purposes of a Make-Whole Fundamental Change), the Company shall make appropriate adjustments
to each to account for any adjustment to the Conversion Rate that becomes effective, or any event requiring an adjustment to the
Conversion Rate where the Ex-Dividend Date of the event occurs, at any time during the period when the Closing Sale Prices, the
Daily VWAPs, the Daily Conversion Values or the Daily Settlement Amounts are to be calculated. For the avoidance of doubt, the
adjustments made pursuant to this Section 10.04(m) shall be made solely to the extent the Company determines in its good faith
judgment that any such adjustment is necessary, without duplication of any adjustment made pursuant to this Section 10.04.

 

Section
10.05.    Effect of Reclassifications,
Business Combinations, Asset Sales and Corporate Events. If the Company:

 

(a)       
reclassifies or changes its Common Stock (other than changes in par value or from no par value resulting from a subdivision
or combination); or

 

    - 53 -

     

    

 

(b)       consolidates
or merges with or into or enters into a binding share exchange with any Person or sells, leases, transfers, conveys or
otherwise disposes of all or substantially all of the property and assets of the Company and its Subsidiaries taken as a
whole to another Person, and, in either case, holders of Common Stock receive stock, other securities or other property or
assets (including cash or any combination thereof) with respect to or in exchange for their Common Stock, then from and after
the effective date of such transaction (a “Merger Event”), the right to convert each outstanding $1,000
principal amount of Notes based on the Common Stock shall, without the consent of any Holders, be changed into a right to
convert each such Note based on the kind and amount of stock, other securities or other property or assets (including cash or
any combination thereof) (the “Reference Property”) that a holder of a number of shares of Common Stock
equal to the Conversion Rate immediately prior to the Merger Event would have been entitled to receive. The Company or the
successor or purchasing corporation, as the case may be, shall execute with the Trustee, without the consent of the Holders,
a supplemental indenture providing that, at and after the Merger Event, the right to convert each outstanding $1,000
principal amount of Notes shall be changed into a right to convert such principal amount of Notes into the kind and amount of
Reference Property that a holder of a number of shares of Common Stock equal to the Conversion Rate immediately prior to such
Merger Event would have been entitled to receive upon such transaction. If the Merger Event causes the Common Stock to be
converted into or exchanged for the right to receive more than a single type of consideration (determined based in part upon
any form of stockholder election), the Reference Property into which the Notes shall become convertible shall be deemed to be
based on the weighted average of the kind and amount of consideration actually received by holders of a majority of the
Common Stock that voted for such an election (if electing between two types of consideration) or holders of a plurality of
the Common Stock that voted for such an election (if electing between more than two types of consideration), as the case may
be, and if no holders of Common Stock affirmatively make such an election, the types and amounts of consideration actually
received by the holders of Common Stock. In all cases the provisions under Section 10.02 shall continue to apply with respect
to the calculation of the consideration due upon conversion, with the Daily Conversion Value, Daily Settlement Amount and the
Daily VWAPs determined based on a unit of Reference Property that a holder of one share of the Common Stock would have
received in such transaction; provided, however, that if the holders of the Common Stock receive only cash in
such Merger Event, the consideration due upon conversion shall equal the Conversion Rate in effect on the Conversion Date, multiplied
by the price paid per share of Common Stock in such transaction, and settlement of any conversion thereafter shall occur
on the third Business Day following the applicable Conversion Date. The Company hereby agrees not to become a party to any
such transaction unless its terms are consistent with the foregoing. Such supplemental indenture shall provide for
adjustments which shall be as nearly equivalent as practicable to the adjustments provided for in this Article 10.

 

When the Company executes a supplemental indenture
pursuant to this Section 10.05, the Company shall promptly file with the Trustee an Officer’s Certificate briefly stating
the reasons therefor, the kind or amount of Reference Property after any such Merger Event, any adjustment to the Conversion Rate
to be made with respect thereto and that all conditions precedent have been complied with, and shall promptly deliver or cause
to be delivered notice thereof to all Holders. The Company shall cause notice of the execution of such supplemental indenture to
be transmitted to each Holder, within 20 days after execution thereof. Failure to deliver any such notice shall not affect the
legality or validity of such supplemental indenture.

 

The above provisions of this Section 10.05
shall similarly apply to successive reclassifications, changes, consolidations, mergers, binding share exchanges, sales, conveyances,
transfers, leases or other dispositions.

 

(c)       
If this Section 10.05 applies to any event or occurrence, Section 10.04 shall not apply.

 

    - 54 -

     

    

 

Section
10.06.    Certain Covenants.
(a) The Company shall, prior to the issuance of any Notes hereunder, and from time to time as may be necessary, reserve out of
its authorized but unissued Common Stock or shares of Common Stock held in treasury, a sufficient number of shares of Common Stock,
free of preemptive rights, to permit the conversion of the Notes.

 

(b)      
The Company covenants that all shares of Common Stock issued upon conversion of Notes shall be duly and validly issued
and fully paid and non-assessable by the Company and free from all taxes, liens and charges with respect to the issue thereof.

 

(c)       
The Company shall endeavor promptly to comply with all federal and state securities laws regulating the issuance
and delivery of shares of Common Stock upon the conversion of Notes, if any, and shall cause to have listed or quoted and shall
keep listed or quoted all such shares of Common Stock on the Relevant Stock Exchange.

 

Section
10.07.    [Reserved].

 

Section
10.08.    Stockholder
Rights Plans. To the extent that any stockholders’ rights plan adopted by the Company is in effect upon conversion of
the Notes, the Holders shall receive, in addition to any Common Stock due upon conversion, the rights under the applicable rights
agreement. However, if, prior to any conversion, the rights have separated from the shares of Common Stock in accordance with the
provisions of the applicable rights plan, the Conversion Rate will be adjusted at the time of separation as if the Company distributed
to all or substantially all Holders of the Common Stock, shares of the Company’s Capital Stock, evidences of indebtedness,
assets, property, rights, options or warrants as described above in Section 10.04(c), subject to readjustment in the event of the
expiration, termination or redemption of such rights. For the avoidance of doubt, any issuance of stockholder rights (including
pursuant to a stockholder rights plan adopted after the date of initial issuance of the Notes) will not cause an adjustment of
the Conversion Rate unless and until such stockholder rights have separated from the Common Stock.

 

Section
10.09.    Responsibility
of Trustee. The Trustee and any other Conversion Agent shall not at any time be under any duty or responsibility to any
Holder to determine the Conversion Rate (or any adjustment thereto) or whether any facts exist that may require any
adjustment (including any increase) of the Conversion Rate, or with respect to the nature or extent or calculation of any
such adjustment when made, or with respect to the method employed, or herein or in any supplemental indenture provided to be
employed, in making the same. The Trustee and any other Conversion Agent shall not be accountable with respect to the
validity or value (or the kind or amount) of any shares of Common Stock, or of any securities, property or cash that may at
any time be issued or delivered upon the conversion of any Note; and the Trustee and any other Conversion Agent make no
representations with respect thereto. Neither the Trustee nor any Conversion Agent shall be responsible for any failure of
the Company to issue, transfer or deliver any shares of Common Stock or stock certificates or other securities or property or
cash upon the surrender of any Note for the purpose of conversion or to comply with any of the duties, responsibilities or
covenants of the Company contained in this Article 10. Without limiting the generality of the foregoing, neither the Trustee
nor any Conversion Agent shall be under any responsibility to determine the correctness of any provisions contained in any
supplemental indenture entered into pursuant to Section 10.05 relating either to the kind or amount of shares of stock or
securities or property (including cash) receivable by Holders upon the conversion of their Notes after any event referred to
in such Section 10.05 or to any adjustment to be made with respect thereto, but, subject to the provisions of Section 9.01,
may accept as conclusive evidence of the correctness of any such provisions, and shall be protected in relying upon, the
Officer’s Certificate (which the Company shall be obligated to file with the Trustee prior to the execution of any such
supplemental indenture) with respect thereto. Neither the Trustee nor the Conversion Agent shall be responsible for
determining whether any event contemplated by Section 10.01 has occurred that makes the Notes eligible for conversion or no
longer eligible therefor until the Company has delivered to the Trustee and the Conversion Agent the notices referred to in
Section 10.01 with respect to the commencement or termination of such conversion rights, on which notices the Trustee and the
Conversion Agent may conclusively rely, and the Company agrees to deliver such notices to the Trustee and the Conversion
Agent immediately after the occurrence of any such event or at such other times as shall be provided for in Section
10.01.

 

    - 55 -

     

    

 

Article
11

Miscellaneous

 

Section
11.01.    Notices.
Notices to the Conversion Agent or Bid Solicitation Agent are deemed given only upon actual receipt by the Conversion Agent or
Bid Solicitation Agent, as applicable.

 

Section
11.02.    No Optional
Redemption. The Notes shall not be redeemable by the Company prior to the Maturity Date, and no sinking fund is provided for
the Notes. Article X and XI of the Base Indenture shall not apply to the Notes.

 

Section
11.03.    When Notes
Disregarded. In determining whether the Holders of the required principal amount of Notes have concurred in any direction,
modification, amendment waiver or consent of the terms of the Indenture, Notes owned by the Company or by any Person directly or
indirectly controlling or controlled by or under direct or indirect common control with the Company shall be disregarded (from
both the numerator and denominator) and deemed not to be outstanding, except that, for the purpose of determining whether the Trustee
shall be protected in relying on any such direction, waiver or consent, only Notes which a Responsible Officer of the Trustee knows
are so owned shall be so disregarded. Subject to the foregoing, only Notes outstanding at the time shall be considered in any such
determination.

 

Section
11.04.    Withholding
Taxes. Notwithstanding any other provision of the Indenture, if the Company or other applicable withholding agent determines,
in its good faith discretion, that it is required by applicable law to pay, and pays, withholding taxes or backup withholding on
behalf of the Holder or beneficial owner as a result of an adjustment to the Conversion Rate, the Company or other applicable withholding
agent may, at its option, set off such payments against payments of cash and shares of Common Stock on the Note (or any payments
on the Company’s Common Stock) or sales proceeds received by or other funds or assets of the Holder or beneficial owner.

 

Section
11.05.    GOVERNING
LAW. THIS THIRD SUPPLEMENTAL INDENTURE AND THE NOTES, AND ANY CLAIM, CONTROVERSY OR DISPUTE ARISING UNDER OR RELATED TO THE
INDENTURE OR THE NOTES, SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF NEW YORK.

 

Section
11.06.    Counterparts.
This Third Supplemental Indenture may be signed in two or more counterparts, each of which shall be an original, with the same
effect as if the signatures thereto and hereto were upon the same instrument. The exchange of signature pages by facsimile or PDF
transmission shall constitute effective execution and delivery of this Third Supplemental Indenture as to the parties hereto.

 

    - 56 -

     

    

 

Section
11.07.    Table of Contents;
Headings. The table of contents, cross-reference sheet and headings of the Articles and Sections of this Third Supplemental
Indenture have been inserted for convenience of reference only, are not intended to be considered a part hereof and shall not modify
or restrict any of the terms or provisions hereof.

 

Section
11.08.    Calculations.
The Company shall be responsible for making all calculations called for under the Notes and for monitoring any Stock Price, Measurement
Period or Observation Period. The calculations include, but are not limited to, determinations of the Closing Sale Price of the
Common Stock, the VWAP of the Common Stock, accrued interest payable on the Notes, any Additional Interest due on the Notes, the
Conversion Rate, the Conversion Price, the Daily Conversion Values and the Additional Shares. The Company or its agents shall make
all these calculations in good faith and, absent manifest error, such calculations shall be final and binding on Holders. The Company
shall provide a schedule of these calculations to each of the Trustee and the Conversion Agent, and each of the Trustee and Conversion
Agent is entitled to rely upon the accuracy of the Company’s calculations without independent verification. The Trustee shall
forward these calculations to any Holder upon the request of such Holder.

 

Section
11.09.    Legal Holidays.
Section 1.13 of the Base Indenture is hereby replaced in full, solely with respect to the Notes, with the following: If
any Interest Payment Date, the Maturity Date or any earlier required Fundamental Change Repurchase Date of a note falls on a day
that is not a Business Day (which for these purposes, “Business Day” shall not include days in which the office where
the Place of Payment is authorized or required by law to be closed), the required payment will be made on the next succeeding Business
Day and no interest on such payment will accrue in respect of the delay.

 

 

[Remainder of page left blank intentionally.]

 

    - 57 -

     

    

 

IN WITNESS WHEREOF, the parties have caused
this Third Supplemental Indenture to be duly executed as of the date first written above.

 

	 	EXACT SCIENCES CORPORATION
 as Issuer
	 	 
	 	By:	  /s/ Jeffrey T. Elliott
	 	 	Name:	Jeffrey T. Elliott
	 	 	Title:	Chief Financial Officer

 

[Signature Page to Third Supplemental Indenture]

 

    

     

    

 

	 	U.S. BANK NATIONAL ASSOCIATION, as Trustee
	 	 
	 	By:	  /s/ Allison Lancaster-Poole
	 	 	Name:	Allison Lancaster-Poole
	 	 	Title:	Vice President

 

[Signature Page to Third Supplemental
Indenture]

 

    

     

    

 

 

EXHIBIT A

 

[FORM OF FACE OF NOTE]

 

[Global Note Legend]

 

UNLESS THIS CERTIFICATE IS PRESENTED BY AN
AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION (“DTC”), TO EXACT SCIENCES CORPORATION
OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE &
CO. OR SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND ANY PAYMENT IS MADE TO CEDE & CO., OR TO
SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR
OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN.

 

TRANSFERS OF THIS GLOBAL SECURITY SHALL BE
LIMITED TO TRANSFERS IN WHOLE, BUT NOT IN PART, TO NOMINEES OF DTC OR TO A SUCCESSOR THEREOF OR SUCH SUCCESSOR’S NOMINEE
AND TRANSFERS OF PORTIONS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS MADE IN ACCORDANCE WITH THE RESTRICTIONS SET FORTH
IN THE INDENTURE REFERRED TO ON THE REVERSE HEREOF.

 

    A-1 

     

    

 

No.               

 

0.3750% Convertible Senior Note due 2028

 

CUSIP No.: [30063P AC9]

 

ISIN No.: [US30063PAC95]

 

EXACT SCIENCES CORPORATION, a corporation
duly organized and validly existing under the laws of the State of Delaware (the “Company,” which term includes
any successor corporation or other entity under the Indenture referred to on the reverse hereof), for value received hereby promises
to pay to CEDE & CO., or registered assigns, the principal amount [Insert if a Global Note: as set forth in the “Schedule
of Exchanges of Notes” attached hereto][Insert if a certificated Note of $[    ]], on March 1,
2028 and interest thereon as set forth below.

 

This Note shall bear interest at the rate
of 0.3750% per year from February 27, 2020 or from the most recent date to which interest had been paid or provided for to, but
excluding, the next scheduled Interest Payment Date until March 1, 2028, unless earlier converted or repurchased. Accrued interest
on this Note shall be computed on the basis of a 360-day year composed of twelve 30-day months and, for a partial month, on the
basis of the number of days actually elapsed in a 30-day month. Interest is payable semi-annually in arrears on each March 1 and
September 1, commencing on September 1, 2020, to Holders of record at the Close of Business on the preceding February 15 and August
15 (whether or not such day is a Business Day), respectively. Additional Interest will be payable as set forth in Section 6.12
of the within-mentioned Indenture, and any reference to interest on, or in respect of, any Note therein shall be deemed to include
Additional Interest if, in such context, Additional Interest is, was or would be payable pursuant to such Section 6.12 and any
express mention of the payment of Additional Interest in any provision therein and herein shall not be construed as excluding Additional
Interest in those provisions thereof and hereof where such express mention is not made.

 

Any Defaulted Interest shall accrue interest
per annum at the rate borne by the Notes from, and including, the relevant payment date to, but excluding, the date on which such
Defaulted Interest shall have been paid by the Company, at its election in accordance with Section 2.06 of the Indenture.

 

The Company shall pay the principal of and
interest on this Note, so long as such Note is a Global Note, in immediately available funds to the Depositary or its nominee,
as the case may be, as the registered Holder of such Note. As provided in and subject to the provisions of the Indenture, the Company
shall pay the principal of any Notes (other than Notes that are Global Notes) upon presentation thereof at the office or agency
designated by the Company for that purpose. The Company has initially designated the Trustee as its Paying Agent and Registrar
in respect of the Notes and the Corporate Trust Office as a place where Notes may be presented for payment or for registration
of transfer.

 

Reference is made to the further provisions
of this Note set forth on the reverse hereof. Such further provisions shall for all purposes have the same effect as though fully
set forth at this place.

 

    A-2 

     

    

 

This Note, and any claim, controversy or
dispute arising under or related to this Note, shall be construed in accordance with and governed by the laws of the State of New
York.

 

In the case of any conflict between this Note
and the Indenture, the provisions of the Indenture shall control and govern.

 

This Note shall not be valid or become obligatory
for any purpose until the certificate of authentication hereon shall have been manually signed by the Trustee or a duly authorized
authenticating agent under the Indenture.

 

[Remainder of page intentionally left
blank]

 

    A-3 

     

    

 

	 	EXACT
    SCIENCES CORPORATION
	 	 
	 	By:	 
	 	 	Name:
	 	 	Title:
	 	 	 
	TRUSTEE’S
    CERTIFICATE OF	 	 
	AUTHENTICATION	 	 

 

This
is one of the Notes referred to in the within-mentioned Indenture.

 

Dated:

 

	U.S.
    BANK NATIONAL ASSOCIATION,	 
	as
    Trustee,	 
	 	 
	By:	 	 
	 	Authorized
    Signatory	 

 

    A-4 

     

    

 

[FORM OF REVERSE SIDE OF NOTE]

 

0.3750% Convertible Senior Note due 2028

 

This Note is one of a duly authorized issue
of Notes of the Company, designated as its 0.3750% Convertible Senior Notes due 2028 (the “Notes”) all issued
under and pursuant to an Indenture dated as of January 17, 2018, between the Company and U.S. Bank National Association, as trustee
(the “Trustee”) the “Base Indenture”), as supplemented by the Third Supplemental Indenture
dated as of February 27, 2020, between the Company and the Trustee (the “Third Supplemental Indenture”, and
together with the Base Indenture, the “Indenture”), to which Indenture and all indentures supplemental thereto
reference is hereby made for a description of the rights, limitations of rights, obligations, duties and immunities thereunder
of the Trustee, the Conversion Agent, the Company and the Holders of the Notes. Additional Notes may be issued in an unlimited
aggregate principal amount, subject to certain conditions specified in the Indenture. The Notes represent that aggregate principal
amount of outstanding Notes from time to time endorsed hereon and the aggregate principal amount of outstanding Notes represented
hereby may from time to time be increased or reduced to reflect purchases, cancellations, conversions or transfers permitted by
the Indenture. In the event of any inconsistency between this Note and the terms of the Indenture, the terms of the Indenture shall
govern.

 

In case an Event of Default, as defined in
the Indenture, shall have occurred and be continuing, the principal of, and interest on, all Notes may be declared, by either the
Trustee or Holders of at least 25% in aggregate principal amount of Notes then outstanding, and upon said declaration shall become,
due and payable, in the manner, with the effect and subject to the conditions and certain exceptions set forth in the Indenture.

 

Subject to the terms and conditions of the
Indenture, the Company will make all payments and deliveries in respect of the Fundamental Change Repurchase Price and the principal
amount on the Maturity Date, as the case may be, to the Holder who surrenders a Note to a Paying Agent to collect such payments
in respect of the Note. The Company will pay cash amounts in money of the United States that at the time of payment is legal tender
for payment of public and private debts. Upon conversion of any Note, the Company shall, at its election, pay or deliver, as the
case may be, cash, shares of Common Stock or a combination of cash and shares of Common Stock.

 

The Indenture contains provisions permitting
the Company and the Trustee in certain circumstances, without the consent of the Holders of the Notes, and in certain other circumstances,
with the consent of the Holders of not less than a majority in aggregate principal amount of the Notes at the time outstanding,
evidenced as in the Indenture provided, to execute supplemental indentures modifying the terms of the Indenture and the Notes as
described therein. It is also provided in the Indenture that, subject to certain exceptions, the Holders of a majority in aggregate
principal amount of the Notes at the time outstanding may on behalf of the Holders of all of the Notes waive any past Default or
Event of Default under the Indenture and its consequences.

 

    

     

    

 

No reference herein to the Indenture and no
provision of this Note or of the Indenture shall alter or impair the obligation of the Company, which is absolute and unconditional,
to pay the principal (including the Fundamental Change Repurchase Price, if applicable) of or the consideration due upon conversion
of, as the case may be, and accrued and unpaid interest on this Note at the place, at the respective times, at the rate and in
the lawful money herein prescribed.

 

The Notes are issuable in registered form
without coupons in denominations of $1,000 principal amount and integral multiples thereof. At the office or agency of the Company
referred to on the face hereof, and in the manner and subject to the limitations provided in the Indenture, Notes may be exchanged
for a like aggregate principal amount of Notes of other authorized denominations, without payment of any service charge but, if
required by the Company or Trustee, with payment of a sum sufficient to cover any transfer or similar tax that may be imposed in
connection therewith as a result of the name of the Holder of the new Notes issued upon such exchange of Notes being different
from the name of the Holder of the old Notes surrendered for such exchange.

 

The Notes are not subject to redemption through
the operation of any sinking fund or otherwise.

 

Upon the occurrence of a Fundamental Change,
the Holder has the right, at such Holder’s option, to require the Company to repurchase for cash all of such Holder’s
Notes or any portion thereof (in principal amounts of $1,000 or integral multiples thereof) on the Fundamental Change Repurchase
Date at a price equal to the Fundamental Change Repurchase Price.

 

Subject to the provisions of the Indenture,
the Holder hereof has the right, at its option, during certain periods and upon the occurrence of certain conditions specified
in the Indenture, prior to the Close of Business on the second Scheduled Trading Day immediately preceding the Maturity Date, to
convert any Notes or portion thereof that is $1,000 or an integral multiple thereof, at the Conversion Rate specified in the Indenture,
as adjusted from time to time as provided in the Indenture.

 

Terms used in this Note and defined in the
Indenture are used herein as therein defined.

 

    A-2 

     

    

 

SCHEDULE OF EXCHANGES OF NOTES
1

 

Exact Sciences Corporation

0.3750% Convertible Senior Notes due 2028

 

The initial principal amount of this Global
Note is [   ] DOLLARS ($[   ]). The following increases or decreases in this Global Note have been
made:

 

	
        Date
	
        Amount
        of decrease

 in principal amount 

of this Global Note
	
        Amount
        of increase

 in principal amount

 of this Global Note
	
        Principal
        amount of 

this Global Note

 following such 

decrease or increase
	
        Signature
        of 

authorized signatory

 of Trustee or 

Custodian

	 	 	 	 	 
	 	 	 	 	 
	 	 	 	 	 

 

 

1       To
be inserted for Global Notes.

 

    A-3 

     

    

 

CONVERSION NOTICE

 

		TO:	EXACT SCIENCES CORPORATION

U.S. BANK NATIONAL ASSOCIATION, as Trustee

 

The undersigned registered owner of this Note
hereby irrevocably exercises the option to convert this Note, or the portion thereof (which is $1,000 or a multiple thereof) below
designated in accordance with the terms of the Indenture referred to in this Note, and directs that the cash and shares of Common
Stock, if any, deliverable upon such conversion and any Notes representing any unconverted principal amount hereof, be issued and
delivered to the registered holder hereof unless a different name has been indicated below. Capitalized terms used herein but not
defined shall have the meanings ascribed to such terms in the Indenture. If shares or any portion of this Note not converted are
to be issued in the name of a person other than the undersigned, the undersigned shall provide the appropriate information below
and pay all transfer taxes payable with respect thereto. Any amount required to be paid by the undersigned on account of interest
accompanies this Note.

 

Dated: 

 

                                                                                 

 

                                                                                 

Signature(s)

 

Signature(s) must be guaranteed by an “eligible
guarantor institution” meeting the requirements of the Registrar, which requirements include membership or participation
in the Security Transfer Agent Medallion Program (“STAMP”) or such other “signature guarantee program”
as may be determined by the Registrar in addition to, or in substitution for, STAMP, all in accordance with the Securities Exchange
Act of 1934, as amended.

 

                                                                                 

Signature Guarantee

 

    A-4 

     

    

 

Fill in the registration of shares of Common
Stock, if any, if to be issued, and Notes if to be delivered, and the person to whom cash and payment for fractional shares is
to be made, if to be made, other than to and in the name of the registered holder:

 

	Please print name and address	 
	 	 
	 	 
	(Name)	 
	 	 
	 	 
	(Street Address)	 
	 	 
	 	 
	(City, State and Zip Code)	 
	 	 
	Principal amount to be converted	 
	(if less than all):	 
	 	 
	$	 	 
	 	 
	Social Security or Other Taxpayer	 
	Identification Number:	 
	 	 
	 	 

 

NOTICE: The signature on this Conversion Notice
must correspond with the name as written upon the face of the Notes in every particular without alteration or enlargement or any
change whatever.

 

    A-5 

     

    

 

FUNDAMENTAL CHANGE REPURCHASE NOTICE

 

		TO:	EXACT SCIENCES CORPORATION

U.S. BANK NATIONAL ASSOCIATION, as Trustee

 

The undersigned registered owner of this Note
hereby irrevocably acknowledges receipt of a notice from Exact Sciences Corporation (the “Company”) regarding the right
of holders to elect to require the Company to repurchase the Notes and requests and instructs the Company to repay the entire principal
amount of this Note, or the portion thereof (which is $1,000 or an integral multiple thereof) below designated, in accordance with
the terms of the Indenture at the price of 100% of such entire principal amount or portion thereof, together with accrued and unpaid
interest to, but excluding, the Fundamental Change Repurchase Date to the registered holder hereof. Capitalized terms used herein
but not defined shall have the meanings ascribed to such terms in the Indenture. The Notes shall be repurchased by the Company
as of the Fundamental Change Repurchase Date pursuant to the terms and conditions specified in the Indenture.

 

Dated:                                                

 

	 	Signature(s):	 
	 	

 

 

Signature(s) must be guaranteed by an “eligible
guarantor institution” meeting the requirements of the Registrar, which requirements include membership or participation
in the Security Transfer Agent Medallion Program (“STAMP”) or such other “signature guarantee program”
as may be determined by the Registrar in addition to, or in substitution for, STAMP, all in accordance with the Securities Exchange
Act of 1934, as amended.

 

	 	 
	 	Signature Guarantee

 

NOTICE: The above signatures of the holder(s) hereof must correspond
with the name as written upon the face of the Notes in every particular without alteration or enlargement or any change whatever.

 

Notes Certificate Number (if
applicable):                                                

 

Principal amount to be repurchased (if less
than all, must be $1,000 or whole multiples of $1,000 in excess thereof):                                               

 

Social Security or Other Taxpayer Identification
Number:                                                

 

    A-6Exhibit 10.1

 

SINO-GLOBAL SHIPPING AMERICA, LTD.

 

February 26, 2020

 

Via Email 

 

Dear Mr. Junfeng Xu:

 

This letter shall confirm
our discussions pursuant to which you have indicated your willingness to serve as a Class I director on the Board of Directors
of Sino-Global Shipping America, Ltd. (the “Company”), Chairperson of the Corporate Governance Committee, a member
of the Audit Committee and a member of the Compensation Committee, effective the date herein, until the next annual shareholders
meeting or your earlier resignation or the removal pursuant to the Company’s by-laws.

 

Our company compensates
our non-employee directors for all services they perform as a director of our company, including attendance at Board of Directors
meetings and service as members of committees of the Board of Directors to which they are appointed. The details of such compensation
are:

 

		1.	an annual compensation of $20,000;

		2.	eligible to participate in the Company’s 2014 Stock Incentive Plan, and to be compensated
at the same level of other independent directors’ of the Company.

 

You would also be reimbursed
for all of your out-of-pocket expenses in traveling to and attending meetings of the Board of Directors and committees on which
you would serve.

 

You may indicate your
agreement with these terms by signing and dating this letter agreement and returning it to the undersigned. By signing this letter
agreement, you reconfirm to the Company that you have no contractual commitments or other legal obligations that would prohibit
you from performing your duties for the Company.

 

	 	Very truly yours,
	 	 
	 	SINO-GLOBAL SHIPPING AMERICA, LTD.
	 	 
	 	By:	/s/ Lei Cao
	 	 	Lei Cao
	 	 	President & Chief Executive Officer

 

 

 

I have read and accept and agree to the above terms of employment:

 

	/s/ Junfeng Xu	 
	Signature of Junfeng Xu

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00305-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00305-of-00352.parquet"}]]