Document:

EX-10.10

 Exhibit 10.10 

STANDARD NON-EXCLUSIVE LICENSE AGREEMENT 

[**] VECTORS LICENSE A10571 

TABLE OF CONTENTS 
  

					
		  	 Section 1        Definitions
	  	
		  	 Section 2        Grant
	  	
		  	 Section 3        Due Diligence
	  	
		  	 Section 4        Payments
	  	
		  	 Section 5        Certain Warranties and Disclaimers of UFRF

		  	 Section 6        Record Keeping
	  	
		  	 Section 7        Patent Prosecution
	  	
		  	 Section 8        Infringement and Invalidity
	  	
		  	 Section 9        Term and Termination
	  	
		  	 Section 10      Assignability
	  	
		  	 Section 11      Dispute Resolution Procedures
	  	
		  	 Section 12      Product Liability; Conduct of Business

		  	 Section 13      Use of Names
	  	
		  	 Section 14      Miscellaneous
	  	
		  	 Section 15      Notices
	  	
		  	 Section 16      Contract Formation and Authority
	  	
		  	 Section 17      United States Government Interests

		  	 Section 18      Confidentiality
	  	
			
		  	 Appendix A - Development Plan
	  	
		  	 Appendix B - Development Report
	  	
		  	 Appendix C - UFRF Royalty Report
	  	

 This Agreement is made effective the 18th day of September, 2012, (the “Effective Date”) by and between the
University of Florida Research Foundation, Inc. (hereinafter called “UFRF”), a nonstock, nonprofit Florida corporation, and Applied Genetic Technologies Corporation (hereinafter called “Licensee”), a small entity corporation
organized and existing under the laws of Delaware; 
 WHEREAS, UFRF owns certain inventions that are described in the “Licensed Patents” defined
below, and UFRF is willing to grant a license to Licensee under any one or all of the Licensed Patents and Licensee desires a license under all of them; 

NOW, THEREFORE, in consideration of the mutual covenants and agreements set forth below, the parties covenant and agree as follows: 

 

	Section 1	Definitions 

  

	 	1.1	“Licensed Patents” shall refer to and mean all of the following UFRF intellectual property: 

  

	 	1.1.1	the United States patent(s)/patent application(s) [**], and all United States and foreign patents and patent applications based on this U.S. application; and 

  
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	 	1.1.2	all United States and foreign patents issued from the applications listed in 1.1.1 and from divisionals and continuations of these applications, to the extent the claims are directed to subject matter specifically
described in [**], all to the extent owned or controlled by UFRF. 

  

	 	1.2	“Licensed Product” and “Licensed Process” shall mean: 

  

	 	1.2.1	In the case of a Licensed Product, any product or part thereof, on a country-by-country basis, developed by or on behalf of Licensee that: 

 

	 	(a)	is covered in whole or in part by an issued, unexpired claim or a pending claim contained in the Licensed Patents, in any country in which any product is made, used or sold; or 

 

	 	(b)	is manufactured by using a process which is covered in whole or in part by an issued, unexpired claim or a pending claim contained in the Licensed Patents, in any country in which any such process is used or in which
any such product is used or sold; or 

  

	 	(c)	incorporates, utilizes or was developed utilizing Know-How or which is manufactured using Know-How. 

  

	 	1.2.2	In the case of a Licensed Process, any process, on a country-by-country basis: 

  

	 	(a)	which is covered in whole or in part by an issued, unexpired claim or a pending claim contained in the Licensed Patents in any country in which such process is practiced; or 

 

	 	(b)	which incorporates or utilizes Know-How. 

  

	 	1.3	“Net Sales” shall mean the total dollar amount invoiced on sales of Licensed Products and/or Licensed Processes by licensee, sublicensee or affiliates. Total amount invoiced may include only promotional
discounts allowed in amounts customary in the trade. 

  

	 	1.4	The term “Affiliate” shall mean: (a) any person or entity which controls at least fifty percent (50%) of the equity or voting stock of the Licensee or (b) any person or entity fifty percent
(50%) of whose equity or voting stock is owned or controlled by the Licensee or (c) any person or entity of which at least fifty percent (50%) of the equity or voting stock is owned or controlled by the same person or entity owning or
controlling at least fifty percent (50%) of Licensee. 

  
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	 	1.5	“Sublicense” means, directly or indirectly, to sublicense, grant any other right with respect to, or agree not to assert, any right licensed to Licensee under this Agreement. 

 

	 	1.6	“Sublicensee” means any third party to whom Licensee grants a Sublicense. 

  

	 	1.7	“Development Plan” shall mean a written report summarizing the development activities that are to be undertaken by the Licensee to bring Licensed Products and/or Licensed Processes to the market. The
Development Plan is attached as Appendix A. 

  

	 	1.8	“Development Report” shall mean a written account of Licensee’s progress under the Development Plan having at least the information specified on Appendix B to this Agreement, and shall be sent to the
address specified on Appendix B. 

  

	 	1.9	“Licensed Field” shall mean all fields of use. 

  

	 	1.10	“Licensed Territory” shall be worldwide. 

  

	 	1.11	“Know-How” means unpatented technology and/or information that was developed by the Investigator, including without limitation methods, processes, techniques, compounds, cell lines, materials, sequences,
drawings, indications, data, results of tests, or studies, plans, and expertise, whether patentable or not, which relates specifically to the Licensed Patents and existing on the date hereof, only to the extent wholly owned and controlled by UFRF
and is necessary to exercise the License Patents, except that, Know-How shall not include the Licensed Patents. 

  

	 	1.12	“Investigator” means [**] while employed by the University of Florida, 

  

	Section 2	Grant 

  

	 	2.1	License under Licensed Patents 

 Subject to the terms of this Agreement, UFRF hereby grants to
Licensee a royalty bearing non-exclusive license, limited to the Licensed Field and the Licensed Territory, under the Licensed Patents to make, have made, develop, import, export, offer to sell, sell, have sold and use Licensed Products and/or
Licensed Processes. 
  

	 	2.2	License under Know-How 

 Subject to the terms of this Agreement, UFRF hereby grants to Licensee
a royalty-bearing, non-exclusive license, limited to the Licensed Field and the Licensed Territory, under the Know-How to make, have made, develop, use, lease, import, export, offer to sell, sell and have sold Licensed Products and Licensed
Processes. 

  
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 UFRF shall deliver the Know-How to Licensee promptly following execution of this Agreement in a
manner and form as mutually agreed between the parties. UFRF and Licensee acknowledge and agree that all direct derivatives and modifications to the tyrosine vector gene sequence as provided by UFRF created by Licensee shall be the property of UFRF
and shall be considered Know-How; provided, however that all other materials, substances, modifications, cell lines, derivations, progeny created, developed or produced by Licensee as a result of Licensee’s research or use of the Know-How shall
be the property of Licensee, including any intellectual property right associated therewith. 
  

	 	2.3	Sublicense 

  

	 	2.3.1	Licensee may grant written Sublicenses to third parties provided only that such Sublicense also includes a sublicense to Sublicensee to other intellectual property owned by or licensed to Licensee and not covered by
this Agreement. However, any agreement granting a Sublicense shall state that the Sublicense is subject to the terms and condition of this Agreement and to the termination of this Agreement. Licensee shall have the same responsibility for the
activities of any Sublicensee or Affiliate as if the activities were directly those of Licensee. 

  

	 	2.3.2	In respect to Sublicenses granted by Licensee under Section 2.3.1 above, Licensee shall pay to UFRF an amount equal to what Licensee would have been required to pay to UFRF had Licensee sold the amount of Licensed
Products or Licensed Processes sold by such Sublicensee. In addition, if Licensee receives any fees, minimum royalties, or other payments in consideration for any rights granted under a Sublicense, and such payments are not based directly upon the
amount or value of Licensed Products or Licensed Processes sold by the Sublicensee, then Licensee shall pay UFRF [**] of such payments within thirty (30) days of receipt of any such fees from Sublicensee; provided, however, that Licensee
shall not be obligated to make payment under this Section with respect to (a) amounts paid to Licensee to reimburse Licensee for patent costs paid by Licensee pursuant to Section 7; (b) equity investments in Licensee by a sublicensee
up to the amount of the fair market value of the equity purchased on the date of the investment; and (c) reimbursement received by Licensee for Licensee’s actual future research and development costs for research or development to be
performed by Licensee (together with subcontractors if applicable) and such costs designated for the development of a Licensed Product or Licensed Process; Licensee shall not receive from Sublicensees anything of value in lieu of cash payments in
consideration for any Sublicense under this Agreement without the express prior written permission of UFRF. Licensee shall provide UFRF with a final unredacted copy of each sublicense agreement and any agreement which transfers intellectual property
rights granted hereunder, within thirty (30) days after the execution of the sublicense agreement and further agrees to forward to UFRF annually a copy of such reports received by Licensee from its Sublicensees pertinent to the payments-under
said sublicense agreements. 

  
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	Section 3	Due Diligence 

  

	 	3.1	Development. 

  

	 	3.1.1	Licensee agrees to and warrants that: it has, or will obtain, the expertise necessary to independently evaluate the inventions of the Licensed Patents; it will establish and actively and diligently pursue the
Development Plan (See Appendix A) to the end that the inventions of the Licensed Patents will be utilized to provide Licensed Products and/or Licensed Processes for sale in the retail market within the Licensed Field; and until the date of first
commercial sale of Licensed Products, it will supply UFRF with a written Development Report annually fifteen (15) days after the end of the calendar year (see Appendix B). UFRF’s review of Licensee’s Development Plan and Development
Report is solely to verify the existence of Licensee’s commitment to development activity and to ensure compliance with Licensee’s obligations to commercialize the inventions of the Licensed Patents, as set forth above. 

Licensee agrees that [**] shall occur [**] of this Agreement or UFRF shall have the right to terminate the Agreement pursuant to
Section 9.3 hereto. In addition, Licensee will meet the milestones shown in Appendix D or UFRF shall have the right to terminate the Agreement pursuant to Section 9.3. Licensee will notify UFRF in writing as each milestone is met. 

 

	 	3.1.2	Upon written request by Licensee to negotiate extensions of the date of first commercial sale or any milestones or due dates set forth in Appendix D, such request to be received by UFRF no less than ninety
(90) days prior to any of the due dates subject of such request, set forth in this Section 3.1.2, such request fully describing Licensee’s diligent efforts to achieve the milestone required to be met by such due date, UFRF shall
consider in good faith such requests. Upon granting such request, UFRF and Licensee shall negotiate such extensions in good faith. 

  

	Section 4	Payments, 

  

	 	4.1	License Issue Fee. 

 Licensee agrees to pay to UFRF a license issue fee of [**] within
thirty (30) days of the Effective Date. 
  

	 	4.2	Running Royalty. 

  

	 	4.2.1	 In addition to the Section 4.1 license issue fee, Licensee agrees to pay to UFRF earned royalties calculated as a percentage of Net Sales in
accordance with the terms and conditions of this Agreement. The royalty 

  
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is deemed earned as of the earlier of the date the Licensed Product and/or Licensed Process is actually sold and paid for, the date an invoice is sent by Licensee or its Sublicensee(s), or the
date a Licensed Product and/or Licensed Process is transferred to a third party for any promotional reason. The royalty shall remain fixed while this Agreement is in effect (a) at a rate of [**] of Net Sales of Licensed Products, for
each Licensed Product, on a country-by-country basis, that is (i) covered in whole or part by an issued, unexpired claim or a pending claim contained in the Licensed Patents, in the country in which such Licensed Product is made, imported,
exported, used or sold or (ii) is manufactured using a process which is covered in whole or in part by an issued, unexpired claim or a pending claim contained in the Licensed Patents, in the country in which the Licensed Process is used or
(b) at a rate of [**] for the Net Sales of Licensed Processes, for each License Process, on a country-by-country basis, that is covered in whole or in part by an issued, unexpired claim or a pending claim contained in the Licensed
Patents in the country in which such Licensed Process is practiced. For clarification, only one royalty shall be due with respect to the same unit of Licensed Product. 

 

	 	4.2.2	Royalties are payable for the longer of [**]. 

  

	 	4.2.3	In the event that licenses from third parties are required by Licensee in order to make, have made, use, sell, offer to sell or import any particular Licensed Product or Licensed Process, then the earned royalty which
Licensee is obligated to pay UFRF under Section 4.2 shall be reduced by [**] for each one dollar ($1.00) in royalties which Licensee pays to third parties under such licenses, further provided, however, that the royalties payable to UFRF
under Section 4.2.1 shall not be reduced to less than [**] of the applicable Net Sales. 

  

	 	4.2.4	If a Licensed Product or Licensed Process is covered under another patent of UFRF, the rights to which have been licensed to the Licensee by UFRF under any other license agreement and which license agreement calls for
the payment of royalties, duplicate royalties for the sales of such Licensed Products or Licensed Process shall not be owed to UFRF by Licensee. Under such circumstances, the royalty calculation shall be made only once, even though the sale of the
Licensed Product or Licensed Process may fall under more than one patent and more than one license agreement. If a Licensed Product or Licensed Process is covered under another patent of UFRF, the rights to which have been licensed to Licensee by
UFRF, Licensee shall pay only the highest applicable royalty rates under any one license agreement. 

  
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	 	4.3	Other Payments. 

  

	 	4.3.1	Licensee agrees to pay UFRF Minimum Royalty payments, as follows: 

  

							
	Payment	  	Year	  	 	  	 
	[**]	  	[**]	  		  	

 and every year thereafter on the same date, for the life of this Agreement. 

The Minimum Royalty shall be paid in advance on a quarterly basis for each year in which this Agreement is in effect. The first Minimum
Royalty payment shall be due on December 31st, 2012 and shall be in the amount of [**]. The Minimum Royalty for a given year shall be due in advance and shall be paid in quarterly
installments on March 31, June 30, September 30, and December 31 for the following quarter. Any Minimum Royalty paid in a calendar year will be credited against the earned royalties for that calendar year. It is
understood that the minimum royalties will be applied to earned royalties on a calendar year basis, and that sales of Licensed Products and/or Licensed Processes requiring the payment of earned royalties made during a prior or subsequent calendar
year shall have no effect on the annual Minimum Royalty due UFRF for other than the same calendar year in which the royalties were earned. 
  

	 	4.3.2	In addition to all other payments required under this Agreement, Licensee agrees to pay UFRF milestone payments within thirty (30) days of the first achievement of such milestone, as follows: 

 

					
	Payment	  	Event	  	 
	[**]	  	[**]	  	
	[**]	  	[**]	  	
	[**]	  	[**]	  	
	[**]	  	[**]	  	
	[**]	  	[**]	  	

 If a Licensed Product or Licensed Process is covered under another patent of UFRF, the rights to which have
been licensed to Licensee by UFRF and which license agreement calls for milestone payments for the same milestone event to be paid to UFRF as set forth above, duplicative milestone payments shall not be owed to UFRF by Licensee with respect to a
given Licensed Product or Licensed Process. Under such circumstances, the milestone payments shall be made only once, even though the development milestone may apply to more than one license, provided that the dollar value of the milestone payment
is the greatest of all applicable milestone payments for such License Product or Licensed Process. 
  

	 	4.4	Sublicense Fees 

 Licensee shall pay sublicense fees to UFRF per Section 2.3.2 of this
Agreement within thirty days (30) of the receipt of any such fees from Sublicensee. 
  

	 	4.5	Accounting for Payments. 

  

	 	4.5.1	 Amounts owing to UFRF under Section 4.2 shall be paid on a quarterly basis after the amount of minimum royalties paid is exceeded, with such

  
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amounts due and received by UFRF on or before the thirtieth day following the end of the calendar quarter ending on March 31, June 30, September 30 or December 31 in
which such amounts were earned. The balance of any amounts owing to UFRF pursuant to this Agreement which remain unpaid more than thirty (30) days after they are due to UFRF shall accrue interest until paid at the rate of the lesser of one and
one-half percent (1.5%) per month or the maximum amount allowed under applicable law. However, in no event shall this interest provision be construed as a grant of permission for any payment delays. Licensee shall also be responsible for
repayment to UFRF of any attorney, collection agency, or other out-of-pocket UFRF expenses required to collect overdue payments due from this Section 4.5.1, Section 6.2 or any other applicable section of this Agreement. 

 

	 	4.5.2	Except as otherwise directed, all amounts owing to UFRF under this Agreement shall be paid in U.S. dollars to UFRF at the following address: 

University of Florida Research Foundation, Inc. 

223 Grinter Hall 
 PO Box 115500

 Gainesville, Florida 32611-5500 

Attention: Business Manager 

All monies owing stated in currencies other than U.S. dollars shall be converted at the rate shown in the Federal Reserve Noon Valuation -
Value of Foreign Currencies on the day preceding the payment. 
  

	 	4.5.3	A certified full accounting statement showing how any amounts payable to UFRF under Section 4.2 have been calculated shall be submitted to UFRF on the date of each such payment. Such accounting statements shall
contain a written representation signed by an executive officer of Licensee that states that the statements are true, accurate, and fairly represent all amounts payable to UFRF pursuant to this Agreement. Such accounting shall be on a per-country
and product line, model or trade name basis and shall be summarized on the form shown in Appendix C of this Agreement. In the event no payment is owed to UFRF because the amount of minimum royalties paid has not been exceeded or otherwise, an
accounting demonstrating that fact shall be supplied to UFRF. 

  

	 	4.5.4	UFRF is exempt from paying income taxes under U.S. law. Therefore, all payments due under this Agreement shall be made without deduction for taxes, assessments, or other charges of any kind which may he imposed on UFRF
by any government outside of the United States or any political subdivision of such government with respect to any amounts payable to UFRF pursuant to this Agreement. All such taxes, assessments, or other charges shall be assumed by Licensee.

  
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	Section 5	Certain Warranties and Disclaimers of UFRF 

  

	 	5.1	UFRF warrants that, except as otherwise provided under Section 17.1 of this Agreement with respect to U.S. Government interests, it is the owner of the Licensed Patents or otherwise has the right to grant the
licenses granted to Licensee in this Agreement. However, nothing in this Agreement shall be construed as: 

  

	 	5.1.1	a warranty or representation by UFRF as to the validity of scope of any right included in the Licensed Patents; 

  

	 	5.1.2	a warranty or representation that anything made, used, sold or otherwise disposed of under the license granted in this Agreement will or will not infringe patents of third parties; 

 

	 	5.1.3	an obligation to bring or prosecute actions or suits against third parties for infringement of Licensed Patents; 

  

	 	5.1.4	an obligation to furnish any services other than those specified in this Agreement; or 

  

	 	5.1.5	a warranty or representation by UFRF that it will not grant licenses to others to make, use or sell products not covered by the claims of the Licensed Patents which may be similar and/or compete with products made or
sold by Licensee. 

  

	 	5.2	EXCEPT AS OTHERWISE EXPRESSLY SET FORTH IN THIS AGREEMENT, UFRF MAKES NO REPRESENTATIONS AND EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO WARRANTIES OF MERCHANTABILITY,
FITNESS FOR A PARTICULAR PURPOSE, AND VALIDITY OF PATENT RIGHTS CLAIMS, ISSUED OR PENDING. UFRF ASSUMES NO RESPONSIBILITIES WHATSOEVER WITH RESPECT TO USE, SALE, OR OTHER DISPOSITION BY LICENSEE, ITS SUBLICENSEES, ITS AFFILIATES, OR THEIR VENDEES OR
OTHER TRANSFEREES OF PRODUCT INCORPORATING OR MADE BY USE OF INVENTIONS LICENSED UNDER THIS AGREEMENT. 

  

	Section 6	Record Keeping 

  

	 	6.1	Licensee and each of its Sublicensees or its Affiliates shall keep books and records sufficient to verify the accuracy and completeness of Licensee’s or the Sublicensee’s or the Affiliate’s accounting
referred to above, including without limitation, inventory, purchase and invoice records, manufacturing records, sales analysis, general ledgers, financial statements, and tax returns relating to the Licensed Products and/or Licensed Processes. Such
books and records shall be preserved for a period not less than six years after they are created, both during and after the term of this Agreement. 

  
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	 	6.2	Licensee shall take all steps necessary so that UFRF may within thirty (30) days of its written request, audit, review and/or copy all of the books and records at a single U.S. location to verify the accuracy of
Licensee’s or its Sublicensee’s or its Affiliate’s accounting. Such review may be performed by any authorized employees of UFRF as well as by any attorneys and/or accountants designated by UFRF, upon reasonable notice and during
regular business hours. If a deficiency with regard to any payment hereunder is determined, Licensee shall pay the deficiency within thirty (30) days of receiving notice thereof along with applicable interest as described in Section 4.5.1.
If a royalty payment deficiency for a calendar year exceeds [**] of the royalties paid for that year, then Licensee shall be responsible for paying UFRF’s out-of-pocket expenses incurred with respect to such review. 

 

	 	6.3	At any time during the term of this agreement, UFRF may request in writing that Licensee verify the calculation of any past payments owed to UFRF through the means of a self-audit. Within ninety (90) days of the
request, Licensee shall complete a self-audit of its books and records to verify the accuracy and completeness of the payments owed. Within thirty (30) days of the completion of the self-audit, Licensee shall submit to UFRF a report detailing
the findings of the self-audit and the manner in which it was conducted in order to verify the accuracy and completeness of the payments owed. If Licensee has determined through its self-audit that there is any payment deficiency, Licensee shall pay
UFRF the deficiency along with applicable interest under Section 4.5.1 with the submission of the self-audit report to UFRF. 

  

	Section 7	Patent Prosecution 

  

	 	7.1	UFRF shall diligently prosecute and maintain the Licensed Patents using counsel of its choice. UFRF shall provide Licensee with copies of all patent applications amendments, and other filings with the United States
Patent and Trademark Office and foreign patent offices. UFRF will also provide Licensee with copies of office actions and other communications received by UFRF from the United States Patent and Trademark Office and foreign patent offices relating to
Licensed Patents. Licensee agrees to keep such information confidential. 

  

	 	7.2	Licensee shall pay to UFRF the sum of [**], within 30 days of the Effective Date to partially reimburse any and all expenses associated with preparation, filing, prosecution, issuance, maintenance, defense, and
reporting of the Licensed Patents incurred prior to the Effective Date. 

  

	 	7.3	Licensee shall be responsible for and pay [**] incurred by UFRF related to the preparation, filing, prosecution, issuance, maintenance, defense and reporting of the Licensed Patents subsequent to and separate of
those expenses cited in section 7.2 within thirty (30) days of receipt of an invoice from UFRF. It shall be the responsibility of Licensee to keep UFRF fully apprised of the “small entity” status of Licensee with respect to the U.S.
patent laws and with respect to the patent laws of any other countries, if applicable, and to inform UFRF of any changes in such status, within thirty days of any such change. 

  
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	Section 8	Infringement and Invalidity 

  

	 	8.1	UFRF shall have the sole right to determine, in its sole and absolute discretion, whether or not to take action in connection with any infringement or alleged infringement of the Licensed Patents. In no event shall UFRF
be obligated to take any action in connection with any infringement or alleged infringement of the Licensed Patents nor shall Licensee have any right to take action with respect to infringement of the Licensed Patents. 

 

	 	8.2	If UFRF prosecutes any such infringement, Licensee agrees that UFRF may include Licensee as a co-plaintiff in any such suit, without expense to Licensee. 

 

	 	8.3	Licensee shall, at the request and expense of UFRF, cooperate in all respects and, to the extent possible, have its employees testify when requested and make available relevant records, papers, information, samples,
specimens, and the like. 

  

	 	8.4	In the event a declaratory judgment action alleging invalidity or non-infringement of any of the Licensed Patents shall be brought against Licensee, UFRF, at its option, shall have the right, within thirty
(30) days after commencement of such action, to intervene and take over the sole defense of the action at its own expense. 

  

	 	8.5	In the event Licensee contests the validity of any Licensed Patents, Licensee shall continue to pay royalties and make other payments pursuant to this Agreement with respect to that patent as if such contest were not
underway until the patent is adjudicated invalid or unenforceable by a court of last resort. 

  

	Section 9	Term and Termination 

  

	 	9.1	The term of this license shall begin on the Effective Date of this Agreement and continue until the later of the date that no Licensed Patent remains an enforceable patent and the date on which Licensee’s
obligation to pay royalties expires pursuant to Section 4.2 above. 

  

	 	9.2	Licensee may terminate this Agreement at any time by giving at least sixty (60) days written notice of such termination to UFRF. Such a notice shall be accompanied by a statement of the reasons for termination.

  

	 	9.3	UFRF may terminate this Agreement by giving Licensee at least sixty (60) days written notice if Licensee fails to remedy any of these problems within such 60-day notice period: 

 

	 	9.3.1	is delinquent on any report or payment 

  
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	 	9.3.2	is not diligently developing and commercializing Licensed Products and Licensed Processes 

  

	 	9.3.3	is in breach of any provision of this Agreement 

  

	 	9.3.4	provides any false report 

  

	 	9.3.5	goes into bankruptcy, liquidation or has a receiver appointed to control any assets 

  

	 	9.3.6	violates any laws or regulations of applicable government entities; or 

  

	 	9.3.7	shall cease to carry on its business pertaining to Licensed Patents. 

  

	 	9.3.8	if payments of earned royalties under Section 4.2 once begun ceases for more than (2) calendar quarters 

  

	 	9.4	UFRF may immediately terminate this Agreement upon the occurrence of the second separate default by Licensee within any consecutive three-year period for failure to pay royalties, patent or any other expenses when due.

  

	 	9.5	Upon the termination of this Agreement for any reason, nothing herein shall be construed to release either party from any obligation that matured prior to the effective date of such termination. Licensee shall remain
obligated to provide an accounting for and to pay royalties earned to the date of termination, and any minimum royalties shall be prorated as of the date of termination by the number of days elapsed in the applicable calendar year. Licensee may,
however, after the effective date of such termination, sell all Licensed Products, and complete Licensed Products in the process of manufacture at the time of such termination and sell the same, provided that Licensee shall remain obligated to
provide an accounting for and to pay running royalties thereon. 

  

	Section 10	Assignability 

  

	 	10.1	This Agreement may not be transferred or assigned by Licensee except with the prior written consent of UFRF, which shall not be unreasonably withheld; provided, however, that Licensee may assign any of its rights under
this Agreement in any country to any Affiliates and may delegate its obligations under this Agreement in any country to any Affiliates; and provided, however, that such assignment shall not relieve Licensee of its responsibilities for performance of
its obligations under this Agreement. Licensee may assign all of its rights and obligations under this Agreement in connection with a merger or similar reorganization or the sale of all or substantially all of the assets and or stock of the
Licensee. This Agreement shall survive any such merger or reorganization of Licensee within, into, or such sale of assets and/or stock to, another party, and no consent for such merger, reorganization or sale shall be required hereunder. Licensee
shall provide UFRF written notice of assignment within thirty (30) days of the effective date of such assignment. Any attempted assignment in contravention of this Section 10.1 shall be null and void and shall constitute a material breach
of this Agreement. 

  
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	 	10.2	The new assignee shall assume all responsibilities of Licensee under this Agreement and must agree in writing to UFRF to be bound by this Agreement. 

 

	Section 11	Dispute Resolution Procedures 

  

	 	11.1	Mandatory Procedures. 

 In the event either party intends to file a lawsuit against the other
with respect to any matter in connection with this Agreement, compliance with the procedures set forth in this Section shall be a condition precedent to the filing of such lawsuit, other than for injunctive relief. Either party may terminate this
Agreement as provided in this Agreement without following the procedures set forth in this section. 
  

	 	11.1.1	When a party intends to invoke the procedures set forth in this section, written notice shall be provided to the other party. Within thirty (30) days of the date of such notice, the parties agree that
representatives designated by the parties shall meet at mutually agreeable times and engage in good faith negotiations at a mutually convenient location to resolve such dispute. 

 

	 	11.1.2	If the parties fail to meet within the time period set forth in section 11.1.1 above or if either party subsequently determines that negotiations between the representatives of the parties are at an impasse, the party
declaring that the negotiations are at an impasse shall give notice to the other party stating with particularity the issues that remain in dispute. 

  

	 	11.1.3	Not more than 15 days after the giving of such notice of issues, each party shall deliver to the other party a list of the names and addresses of at least three individuals, any one of whom would be acceptable as a
neutral advisor in the dispute (the “Neutral Advisor”) to the party delivering the list. Any individual proposed as a Neutral Advisor shall have experience in determining, mediating, evaluating, or trying intellectual property litigation
and shall not be affiliated with the party that is proposing such individual. 

  

	 	11.1.4	Within 10 days after delivery of such lists, the parties shall agree on a Neutral Advisor. If they are unable to so agree within that time, within 5 days, they shall each select one individual from the lists. Within 5
days, the individuals so selected shall meet and appoint a third individual from the lists to serve as the Neutral Advisor. Within 30 days after the selection of a Neutral Advisor: 

 

	 	(a)	The parties shall each provide a written statement of the issues in dispute to the Neutral Advisor. 

  
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	 	(b)	The parties shalt meet with the Neutral Advisor in Gainesville, Florida on a date and time established by the Neutral Advisor. The meeting must be attended by persons authorized to make final decisions on behalf of each
party with respect to the dispute. At the meeting, each party shall make a presentation with respect to its position concerning the dispute. The Neutral Advisor will then discuss the issues separately with each party and attempt to resolve all
issues in the dispute. At the meeting, the parties will enter into a written settlement agreement with respect to all issues that are resolved. Such settlement agreement shall be final and binding with respect to such resolved issues and may not be
the subject of any lawsuit between the parties, other than a suit for enforcement of the settlement agreement. 

  

	 	11.1.5	The expenses of the neutral advisor shall be shared by the parties equally. All other out-of-pocket costs and expenses for the alternative dispute resolution procedure required under this Section shall be paid by the
party incurring the same. 

  

	 	11.1.6	Positions taken and statements made during this alternative dispute resolution procedure shall be deemed settlement negotiations and shall not be admissible for any purpose in any subsequent proceeding.

  

	 	11.2	Failure to Resolve Dispute. 

 If any issue is not resolved at the meeting with the Neutral
Advisor, either party may file appropriate administrative or judicial proceedings with respect to the issue that remains in dispute. No new issues may be included in the lawsuit without the mandatory procedures set forth in this section having first
been followed. 
  

	 	11.3	Survival. 

 The provisions of this Section shall survive termination of this Agreement. 

 

	Section 12	Product Liability; Conduct of Business 

  

	 	12.1	 Licensee and its Sublicensees shall, at all times during the term of this Agreement and thereafter, indemnify, defend and hold UFRF, the Florida Board
of Governors, the University of Florida Board of Trustees, the University of Florida, and each of their directors, officers, employees, and agents, and the inventors of the Licensed Patents, regardless of whether such inventors are employed by the
University of Florida at the time of the claim, harmless against all claims and expenses, including legal expenses and reasonable attorneys’ fees, whether arising from a third party claim or resulting from UFRF’s enforcing this
indemnification clause against Licensee, arising out of the death of or injury to any person or persons or out of any damage to property and against any other claim, proceeding, demand, expense and liability of any kind whatsoever resulting from the

  
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production, manufacture, sale, use, lease, consumption, marketing, or advertisement of Licensed Products or Licensed Process(es) or arising from any right or obligation of Licensee hereunder.
Notwithstanding the above, UFRF at all times reserves the right to retain counsel of its own to defend UFRF’s, the Florida Board of Governors’, the University of Florida Board of Trustees’, the University of Florida’s, and the
inventor’s interests. 

  

	 	12.2	Licensee warrants that it now maintains and will continue to maintain liability insurance coverage appropriate to the risk involved in producing, manufacturing, selling, marketing, using, leasing, consuming, or
advertising the products subject to this Agreement and that such insurance coverage lists UFRF, the Florida Board of Governors, the University of Florida Board of Trustees, the University of Florida, and the inventors of the Licensed Patents as
additional insureds. Within thirty (30) days after the execution of this Agreement and thereafter annually between January 1 and January 31 of each year, Licensee will present evidence to UFRF that the coverage is being maintained
with UFRF, the University of Florida, and its inventors listed as additional insureds. In addition, Licensee shall provide UFRF with at least thirty (30) days prior written notice of any change in or cancellation of the insurance coverage.

  

	Section 13	Use of Names 

 Licensee and its Sublicensees shall not use the names of UFRF, or
of the University of Florida, nor of any of either institution’s employees, agents, or affiliates, nor the name of any inventor of Licensed Patents, nor any adaptation of such names, in any promotional, advertising or marketing materials or any
other similar form of publicity, or to suggest any endorsement by the such entities or individuals, without the prior written approval of UFRF in each case. 
  

	Section 14	Miscellaneous 

  

	 	14.1	This Agreement shall be construed in accordance with the internal laws of the State of Florida 

  

	 	14.2	The parties hereto are independent contractors and not joint venturers or partners. 

  

	 	14.3	Licensee shall ensure that it applies patent markings that meet all requirements of U.S. law, 35 U.S.C. §287, with respect to all Licensed Products subject to this Agreement. 

 

	 	14.4	This Agreement constitutes the full understanding between the parties with reference to the subject matter hereof, and no statements or agreements by or between the parties, whether orally or in writing, shall vary or
modify the written terms of this Agreement. Neither party shall claim any amendment, modification, or release from any provisions of this Agreement by mutual agreement, acknowledgment, or otherwise, unless such mutual agreement is in writing, signed
by the other party, and specifically states that it is an amendment to this Agreement. 

  
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	 	14.5	Licensee shall not encumber or otherwise grant a security interest in any of the rights granted hereunder to any third party. 

  

	 	14.6	Licensee acknowledges that it is subject to and agrees to abide by the United States laws and regulations (including the Export Administration Act of 1979 and Arms Export Control Act) controlling the export of technical
data, computer software, laboratory prototypes, biological material, and other commodities. The transfer of such items may require a license from the cognizant agency of the U.S. Government or written assurances by Licensee that it shall not export
such items to certain foreign countries and/or foreign persons without prior approval of such agency. UFRF neither represents that a license is or is not required or that, if required, it shall be issued. 

 

	 	14.7	Licensee is responsible for any and all wire/bank fees associated with all payments due to UFRF pursuant to this agreement. 

  

	 	14.8	Survival 

 The provisions of this Section shall survive termination of this Agreement. Upon
termination of the Agreement for any reason, the following sections of the License Agreement will remain in force as non-cancelable obligations: 
  

					
	•	    	Section 6	    	Record Keeping
			
	•	    	Section 9	    	Requirement to pay royalties on sale of Licensed Products made, and in process, at the time of License Agreement termination
			
	•	    	Section 12	    	Product Liability; Conduct of Business
			
	•	    	Section 13	    	Use of Names
			
	•	    	Section 18	    	Confidentiality

  

	Section 15	Notices 

 Any notice required to be given pursuant to the provisions of this
Agreement shall be in writing and shall be deemed to have been given 
  

	 	•	 	when delivered personally, or 

  

	 	•	 	if sent by facsimile transmission, when receipt thereof is acknowledged at the facsimile number of the recipient as set forth below, or 

 

	 	•	 	the second day following the day on which the notice has been delivered prepaid to a courier service, or 

  

	 	•	 	five (5) business days following deposit in the U.S. mall if sent certified mail, (return receipt acknowledgement is not required to certify delivery). 

  
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	 	15.1	If to the University of Florida Research Foundation, Inc.: 

 President 

University of Florida Research Foundation, Inc. 

223 Grinter Hall 
 University of
Florida 
 Post Office Box 115500 

Gainesville, FL 32611-5500 

Facsimile Number: 352-846-0505 

with a copy to: 
 Office of
Technology Licensing 
 Attn: Director 

747 SW Second Avenue 

University of Florida 
 Post
Office Box 115575 
 Gainesville, Florida 32611-5575 

Facsimile Number: 352-392-6600 
  

	 	15.2	If to Licensee: 

 Sue Washer, CEO 

Applied Genetic Technologies Corporation 

11801 Research Drive, Suite D 

Alachua, FL 32615 
 Facsimile
Number 386-462-0875 
 With a copy to 

Fred Hutchison 
 Hutchison Law
Group 
 5410 Trinity Road 

Suite 400 
 Raleigh, North
Carolina 27607 
  

	Section 16	Contract Formation and Authority 

 The submission of this Agreement does not
constitute an offer, and this document shall become effective and binding only upon the execution by duly authorized representatives of both Licensee and UFRF. Copies of this Agreement that have not been executed and delivered by both UFRF and
Licensee shall not serve as a memorandum or other writing evidencing an agreement between the parties. This Agreement shall automatically terminate and be of no further force and effect, without the requirement of any notice from UFRF to Licensee,
if UFRF does not receive the License Issue Fee or certificates representing shares issued to UFRF pursuant to this Agreement, as applicable, within thirty (30) days of the Effective Date. 

 

	 	16.1	UFRF and Licensee hereby warrant and represent that the persons signing this Agreement have authority to execute this Agreement on behalf of the party for whom they have signed. 

  
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	 	16.2	Force Majeure. 

 No default, delay, or failure to perform on the part of Licensee or UFRF shall
be considered a default, delay or failure to perform otherwise chargeable hereunder, if such default, delay or failure to perform is due to causes beyond either party’s reasonable control including, but not limited to: strikes, lockouts, or
inactions of governmental authorities, epidemics, war, embargoes, fire, earthquake, acts of God, or default of common carrier. In the event of such default, delay or failure to perform, any date or times by which either party is otherwise scheduled
to perform shall be extended automatically for a period of time equal in duration to the time lost by reason of the excused default, delay or failure to perform. 
  

	Section 17	United States Government Interests 

  

	 	17.1	It is understood that the United States Government (through any of its agencies or otherwise) has funded research, [**], during the course of or under which any of the inventions of the Licensed Patents were
conceived or made. The United States Government is entitled, as a right, under the provisions of 35 U.S.C. §202-212 and applicable regulations of Title 37 of the Code of Federal Regulations, to a non-exclusive, nontransferable, irrevocable,
paid-up license to practice or have practiced the inventions of such Licensed Patents for governmental purposes. Any license granted to Licensee in this Agreement shall be subject to such right. 

 

	 	17.2	Licensee agrees that for Licensed Products covered by the Licensed Patents that are subject to the non-exclusive royalty-free license to the United States Government, said Licensed Products will be manufactured
substantially in the United States. Licensee further agrees that it shall abide by all the requirements and limitations of U.S. Code, Title 35, Chapter 18, and implementing regulations thereof, for all patent applications and patents invented in
whole or in part with federal money. 

  

	Section 18	Confidentiality 

  

	 	18.1	 Each Party shall maintain all information of the other Party which is treated by such other Party as proprietary or confidential (referred to herein
as “Confidential Information”) in confidence, and shall not disclose, divulge or otherwise communicate such confidential information to others, or use it for any purpose, except pursuant to, and in order to carry out, the terms and
objectives of this Agreement, and each party hereby agrees to exercise every reasonable precaution to prevent and restrain the unauthorized disclosure of such confidential information by any of its Affiliates, directors, officers, employees,
consultants, subcontractors, Sublicensees or agents. Licensee’s Confidential Information includes but is not limited to the Development Plan, Development Reports and all other financial, research, development or business reports, strategies and
agreements, including Sublicenses, of Licensee. The parties agree to keep the terms of this Agreement confidential, provided that each party may disclose this Agreement to their authorized agents and investors who are bound by similar

  
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confidentiality provisions. Notwithstanding the foregoing, Confidential Information of a party shall not include information which: (a) was lawfully known by the receiving party prior to
disclosure of such information by the disclosing party to the receiving party; (b) was or becomes generally available in the public domain, without the fault of the receiving party; (c) is subsequently disclosed to the receiving party by a
third party having a lawful right to make such disclosure; (d) is required by law, rule, regulation or legal process to be disclosed, provided that the receiving party making such disclosure shall take alt reasonable steps to restrict and
maintain to the extent possible confidentiality of such disclosure and shall provide reasonable notice to the other party to allow such party the opportunity to oppose the required disclosure; or (e) has been independently developed by
employees or others on behalf of the receiving party without access to or use of disclosing party’s information as demonstrated by written record. Each party’s obligations under this Section 18 shall extend for a period of five
(5) years from termination or expiration of this Agreement. 

  
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 IN WITNESS WHEREOF, the parties hereto have duly executed this Agreement on the dates indicated below. UNIVERSITY
OF FLORIDA RESEARCH FOUNDATION, INC. 
  

							
	UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
				
	 /s/ David L. Day
	 		 	Date:	 	9/14, 2012
	David L. Day	 		 		 	
	Director of Technology Licensing	 		 		 	

  

									
	 LICENSEE
 APPLIED GENETIC
TECHNOLOGIES CORPORATION

					
	By:	 	 /s/ Susan B. Washer
	 		 	Date:	 	9/18, 2012
	Susan B. Washer, President and CEO	 		 		 	

  
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 Appendix A - Development Plan 

A Development Plan of the scope outlined below shall be submitted to UFRF by Licensee prior to the execution of this agreement. In general, the plan should
provide UFRF with a summary overview of the activities that Licensee. 
  

	1.	Development Program 

  

	 	A.	Development activities to be undertaken 

 [**] 

 

	II.	Governmental Approval 

 [**] 

 

	III.	Proposed Market Approach 

 [**] 

 

	IV.	Competitive Information 

 [**] 

  
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 Appendix B - Development Report 

When appropriate, indicate estimated start date and finish date for activities. 
  

	I.	Date Development Plan Initiated and Time Period Covered by this Report. 

  

	II.	Development Report (4-8 paragraphs). 

  

	 	A.	Activities completed since last report including the object and parameters of the development, when initiated, when completed and the results. 

 

	 	B.	Activities currently under investigation, i.e., ongoing activities including object and parameters of such activities, when initiated, and projected date of completion. 

 

	III.	Future Development Activities (4-8 paragraphs). 

  

	 	A.	Activities to be undertaken before next report including, but not limited to, the type and object of any studies conducted and their projected starting and completion dates. 

 

	 	B.	Estimated total development time remaining before a product will be commercialized. 

  

	 	C.	One year before commencement of manufacturing or commercial production, Licensee will include in the Development Report specifics of planned manufacturing or production 

 

	IV.	Changes to Initial Development Plan (2-4 paragraphs). 

  

	 	A.	Reasons for change. 

  

	 	B.	Variables that may cause additional changes. 

  

	V.	Items to be Provided if Applicable: 

  

	 	A.	Information relating to Licensed Products that has become publicly available, e.g., published articles, competing products, patents, etc. 

 

	 	B.	Development work being performed by third parties, other than Licensee, to include name of third party, reasons for use of third party, planned future uses of third parties including reasons why and type of work.

  

	 	C.	Update of competitive information trends in industry, government compliance (if applicable) and market plan. 

  

	 	D.	Information and copies of relevant materials evidencing the status of any patent applications or other protection relating to Licensed Products or the Licensed Patents. 

 

	 	E.	One year before commencement of manufacturing or commercial production, Licensee will include in the Development Report specifics of planned manufacturing or production. 

PLEASE SEND DEVELOPMENT REPORTS TO: 

University of Florida Research Foundation, Inc. 

Attn: Director 
 The Innovation
Hub 
 747 SW Second Avenue 

P.O. Box 115575 
 Gainesville, FL
32611-5575 
 Facsimile: 352-392-6600 

  
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 Appendix C 

UFRF Royalty Report 

 

			
	Licensee:	 	  

			
		
	Inventor:	 	  

			
		
	Period Covered:         From:	 	  

			
		
	Prepared By	 	  

			
		
	Approved By:	 	  

 

					
		 	Agreement:	 	  

					
			
		 	P#:	 	
        P

							
			
	Through:	 	  
	 	

					
			
		 	Date:	 	  

					
			
		 	Date:	 	  

 
 

 If license covers several major product lines, please prepare a separate report 

for each line. Then combine all product lines into a summary report. 
  

									
	      Report Type:     ̈	  	Single Product Line Report:	 	  

									
		
	                                 
 ̈	  	Multiproduct Summary Report. Page 1 of              Pages

													
							
	                                 
 ̈	  	Product Line Detail. Line:	 	  
	 	Tradename:	 	  
	 	Page:	 	  

									
					
	Report Currency:   ̈	  	U. S. Dollars	 	 ̈	  	Other	 	  

  

													
	 	  	Gross	  	* Less:	  	Net	  	Royalty	  	Period Royalty Amount
	Country	  	Sales	  	Allowances	  	Sales	  	Rate	  	This Year	  	Last Year
	 U.S.A.
	  		  		  		  		  		  	
	 Canada
	  		  		  		  		  		  	
	 Europe:
	  		  		  		  		  		  	
							
	 Japan
	  		  		  		  		  		  	
	 Other:
	  		  		  		  		  		  	
							
	 TOTAL:
	  		  		  		  		  		  	

 Total Royalty:
                             Conversion Rate:
                             Royalty in U.S. Dollars:
    $                             

The following royalty forecast is non-binding and for UFRF’s internal planning purposes only: 

Royalty Forecast Under This Agreement: Next Quarter:            
Q2:             Q3:             Q4:            

  

					
		  	 * On a separate page, please indicate the reasons for returns or other adjustments if significant.

Also note any unusual occurrences that affected royalty amounts during this period.

To assist UFRF’s forecasting, please comment on any significant expected trends in sales volume.
	 	

  
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 Appendix D – Milestones 

 

	1.	Licensee has already provided UFRF a preliminary Development Plan. Within six months of execution of this license, Licensee will provide UFRF a detailed document covering Licensee’s plans as to projected product
development, markets and sales forecasts, manufacturing and operations, and financial forecasts (“Business Plan”). UFRF will treat this Business Plan as confidential information and to protect it as UFRF would its own confidential
information. 

 [**] 

  
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 Exhibit 10.11 

STANDARD EXCLUSIVE LICENSE AGREEMENT 

WITH KNOW HOW 

[**] VECTORS LICENSE-A12044 

TABLE OF CONTENTS 
  

			
	 Section 1
	    	 Definitions

	 Section 2
	    	 Grant

	 Section 3
	    	 Due Diligence

	 Section 4
	    	 Payments

	 Section 5
	    	 Certain Warranties and Disclaimers of UFRF

	 Section 6
	    	 Record Keeping

	 Section 7
	    	 Patent Prosecution

	 Section 8
	    	 Infringement and Invalidity

	 Section 9
	    	 Term and Termination

	 Section 10
	    	 Assignability

	 Section 11
	    	 Dispute Resolution Procedures

	 Section 12
	    	 Product Liability; Conduct of Business

	 Section 13
	    	 Use of Names

	 Section 14
	    	 Miscellaneous

	 Section 15
	    	 Notices

	 Section 16
	    	 Contract Formation and Authority

	 Section 17
	    	 United States Government Interests

	 Section 18
	    	 Confidentiality

	 Section 19
	    	 University Rules and Regulations

	
	Schedule 1 — Patents and Patent Applications
	Appendix A - Development Plan
	Appendix B - Development. Report
	Appendix C - UFRF Royalty Report
	Appendix D - Milestones

 This Agreement Is made effective the 5th day of November, 2012, (the “Effective Date”) by and
between the University of Florida Research Foundation, Inc. (hereinafter called “UFRF”), a nonstock, nonprofit Florida corporation, and Applied Genetic Technologies Corporation (hereinafter called “Licensee”), a small entity
corporation organized and existing under the laws of Delaware; 
 WHEREAS, UFRF owns certain inventions that are described in the
“Licensed Patents” defined below, and UFRF is willing to grant a license to Licensee under any one or all of the Licensed Patents and Licensee desires a license under all of them; 

WHEREAS, pursuant to that certain Standard Non-Exclusive License Tyrosine Vectors license A10571 by and between UFRF and Licensee and dated
effective as of September 18, 2012 (the “NonExclusive License”), UFRF has-granted to Licensee a non-exclusive license in and to the Licensed Patents, and 

  
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 WHEREAS, in addition to the non-exclusive rights granted to Licensee pursuant to the NonExclusive
License, UFRF is willing to grant an exclusive license to Licensee under the Licensed Patents as set forth herein. 
 NOW, THEREFORE, in
consideration of the mutual covenants and agreements set forth below, the parties covenant and agree as follows: 
  

	Section 1	Definitions 

  

	 	1.1	“Licensed Patents” means all of the following UFRF intellectual property: 

  

	 	1.1.1	the United States patent(s)/patent application(s) [**] and all United States and foreign patents and patent applications based on the U.S. application, and 

all United States and foreign patents issued from the applications listed in 1.1.1 above and from divisionals and continuations of these
applications, to the extent the claims are directed to subject matter specifically described in [**], all to the extent owned or controlled by UFRF. 
  

	 	1.2	“Licensed Product” and “Licensed Process” means: 

  

	 	1.2.1	In the case of a Licensed Product, any product or part thereof, on a country-by-country basis, developed by or on behalf of Licensee, that: 

 

	 	(a)	is covered in whole or in part by an issued, unexpired claim or a pending claim contained in the Licensed Patents, in any country in which such product is made, used or sold; or 

 

	 	(b)	is manufactured by using a process which is covered in whole or in part by an issued, unexpired claim or a pending claim contained in the Licensed Patents, in any country in which any such process is used or in which
any such product is used or sold. 

  

	 	(c)	incorporates, utilizes, or was developed utilizing, Know-How or which is manufactured using Know-How; 

  

	 	1.2.2	In the case of a Licensed Process, any process, on a country-by-country basis: 

  

	 	(a)	which is covered in whole or in part by an issued, unexpired claim or a pending claim contained in the Licensed Patents in any country in which such process is practiced. 

 

	 	(b)	(which incorporates, utilizes, or was developed utilizing, Know-How 

  
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	 	1.3	“Net Sales” means the total dollar amount invoiced on sales of Licensed Products and/or Licensed Processes by licensee, sublicensee or affiliates. Total amount invoiced may include only promotional discounts
allowed in amounts customary in the trade. 

  

	 	1.4	“Affiliate” means: (a) any person or entity which controls at least fifty percent (50%) of the equity or voting stock of the Licensee or (b) any person or entity fifty percent (50%) of
whose equity or voting stock is owned or controlled by the Licensee or (c) any person or entity of which at least fifty percent (50%) of the equity or voting stock is owned or controlled by the sane person or entity owning or controlling
at least fifty percent (50%) of Licensee. 

  

	 	1.5	“Patent Challenge” means a challenge to the validity, patentability, enforceability and/or non-infringement of any of the Licensed Patents or otherwise opposing any of the Licensed Patents. 

 

	 	1.6	“Sublicense” means, directly or indirectly, to sublicense, grant any other right with respect to, or agree not to assert, any right licensed to Licensee under this Agreement. 

 

	 	1.7	“Sublicensee” means any third party to whom Licensee grants a Sublicense. 

  

	 	1.8	“Development Plan” means a written report summarizing the development activities that are to be undertaken by the Licensee to bring Licensed Products and/or Licensed Processes to the market. The Development
Plan is attached as Appendix A. 

  

	 	1.9	“Development Report” means a written account of Licensee’s progress under the Development Plan having at least the information specified on Appendix B to this Agreement, and shall be sent to the address
specified on Appendix B. 

  

	 	1.10	“Licensed Field” shall be limited to the field of Achromatopsia, X-Linked Retinoschisis and X-linked Retinitis Pigmentosa on an exclusive basis (the “Exclusive Field”) and shall include on a
partially exclusive basis as set forth in Section 2 all other uses in the field of orphan ophthalmology (the “Semi-Exclusive Field”). 

  

	 	1.11	“Licensed Territory” shall be worldwide. 

  

	 	1.12	“Investigator” mean [**] while employed by the University of Florida. 

  

	 	1.13	“Know-How” means unpatented, technology and/or information that was developed by the Investigator, including without limitation methods, processes, techniques, compounds, cell lines, materials, sequences,
drawings, indications, data, results of tests, or studies, plans, and expertise, whether patentable or not, which relates specifically to the Licensed Patents and existing on the date hereof, only to the extent wholly owned and controlled by UFRF,
and is necessary to exercise the Licensed Patents, except that, Know-How shall not include the Licensed Patents. 

  
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	Section 2	Grant 

  

	 	2.1	License 

  

	 	2.1.1	License under Licensed Patents 

 Subject to the terms of this Agreement, UFRF hereby grants to
Licensee a royalty-bearing license, limited to the Licensed Field and the Licensed Territory, under the Licensed Patents to make, have made, develop, use, lease, import, export, offer to sell, and have sold Licensed Products and Licensed Processes.
This license shall be exclusive for the Exclusive Field and UFRF further agrees that the license for all other uses in the Licensed Field shall be semi-exclusive and that UFRF shall not grant any future licenses to any third party for use in the
Semi-Exclusive Field provided that Licensee acknowledges that UFRF has prior to the Effective Date granted to certain third parties licenses under the Licensed Patents that include use in the Semi-Exclusive Field. UFRF reserves to itself and the
University of Florida the right under the Licensed Patents to make, have made, develop, import and use Licensed Products and Licensed Processes solely for their internal, research, clinical (including, but not limited to patient care at Shands
Teaching Hospital and University of Florida patient care facilities) and educational purposes. In addition, UFRF reserves to itself, as well as to the University of Florida and to all non-profit research institutions, the right to use materials that
might be covered under Licensed Patents solely for their internal research, educational, and clinical purposes and to meet all applicable governmental requirements governing the ability to transfer materials. 

 

	 	2.1.2	License under Licensed Know-How 

 Subject to the terms of this Agreement, UFRF hereby grants to
Licensee a royalty-bearing, non-exclusive license, limited to the Licensed Field and the Licensed Territory, under the Know-How to make, have made, develop, use, lease, import, export, offer to sell, sell and have sold Licensed Products and Licensed
Processes. 
 UFRF shall deliver the Know-How to Licensee promptly following execution of this Agreement in a manner and form as mutually
agreed between the parties. UFRF and Licensee acknowledge and agree that all direct derivatives and modifications to the tyrosine gene sequence as provided by UFRF created by Licensee shall be the property of UFRF and shall be consider Know-How;
provided, however that all other materials, substances, modifications, cell lines, derivations, progeny created, developed or produced by Licensee as a result of Licensee’s research or use of the Know-How shall be the property of Licensee,
including the intellectual property rights associated therewith. 

  
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	 	2.2	Sublicense 

  

	 	2.2.1	Licensee may grant written Sublicenses to third parties. However, Licensee shall notify UFRF of the initiation of license negotiations with all potential Sublicensees. Any agreement granting a Sublicense shall state
that the Sublicense is subject to the terms and conditions of this Agreement and to the termination of this Agreement. Licensee shall have the same responsibility for the activities of any Sublicensee or Affiliate as if the activities were directly
those of Licensee. Licensee shall also include provisions in all sublicenses to provide that in the event that Sublicensee brings a Patent Challenge against UFRF or assists another party in bringing a Patent Challenge against UFRF (except as
required under a court order or subpoena) then Licensee may terminate the Sublicense within thirty (30) days. 

  

	 	2.2.2	In respect to Sublicenses granted by Licensee under 2.2.1 above, Licensee shall pay to UFRF an amount equal to what Licensee would have been required to pay to UFRF had Licensee sold the amount of Licensed Products or
Licensed Processes sold by such Sublicensee. In addition, if Licensee receives any fees, minimum royalties, or other payments in consideration for any rights granted under a Sublicense, and such payments are not based directly upon the amount or
value of Licensed Products or Licensed Processes sold by the Sublicensee, then Licensee shall pay UFRF [**] of such payments within thirty (30) days of receipt of any such fees from Sublicensee; provided, however, that Licensee shall not
be obligated to make payment under this Section with respect to (a) amounts paid to Licensee to reimburse Licensee for patent costs paid by Licensee pursuant to Section 7; (b) equity investments in Licensee by a sublicensee up to the
amount of the fair market value of the equity purchased on the date of the investment; and (c) reimbursement received by Licensee for actual future research and development costs for research or development to be performed by Licensee (together
with subcontractors if applicable) and such cost designated for the development of a Licensed Product or Licensed Process. Licensee shall not receive from Sublicensees anything of value in lieu of cash payments in consideration for any Sublicense
under this Agreement without the express prior written permission of UFRF. For clarification, if the rights sublicensed have been licensed to Licensee by UFRF under another license agreement, including the NonExclusive License, Licensee shall not be
required to pay duplicate sub licensee fees to UFRF. Under such circumstances, the calculation for a sublicense fee as set forth in this Section 2.2.2 shall be made only once provided however that Licensee shall pay the greatest of the
applicable sublicense rates. 

 If Licensee or any of its Affiliates brings a Patent Challenge against UFRF, or
(ii) Licensee or any of its Affiliates assists another party in bringing a Patent Challenge against UFRF (except as required under a 

  
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court order or subpoena), and (iii) UFRF does not choose to exercise its rights to terminate this Agreement pursuant to Section 9.3 then, in the event that such a Patent Challenge is
successful, Licensee will have no right to recoup any consideration, including royalties, paid during the period of challenge. In the event that a Patent Challenge is unsuccessful, Licensee shall reimburse UFRF for all reasonable legal fees and
expenses incurred in its defense against the Patent Challenge. 
  

	 	2.2.3	Licensee shall provide UFRF with a final unredacted copy of each sublicense agreement and any agreement which transfers intellectual property rights granted hereunder, within thirty (30) days after the execution of
the sublicense agreement and further agrees to forward to UFRF annually a copy of such reports received by Licensee from its Sublicensees pertinent to the payments under said sublicense agreements. 

 

	 	2.2.4	In the event that UFRF notifies Licensee in writing of a third party’s Interest in a market or territory included in the Licensed Field or Licensed Territory which Licensee is not addressing or intending to
address, as evidenced by diligent developmental plan provided to UFRF after thirty (30) days of UFRF notification to Licensee of the third party interest, at the time of receipt of the notice and at UFRF’s request, Licensee shall enter
into good faith discussions with such third party with respect to a Sublicense. 

  

	Section 3	Due Diligence 

  

	 	3.1	Development 

  

	 	3.1.1	Licensee agrees to and warrants that: 

  

	 	(a)	it has, or will obtain, the expertise necessary to independently evaluate the inventions of the Licensed Patents; 

  

	 	(b)	it will establish and actively and diligently pursue the Development Plan (see Appendix A) to the end that the inventions of the Licensed Patents will be utilized to provide Licensed Products and/or Licensed Processes
for sale in the retail market within the Licensed Field; 

  

	 	(c)	it will diligently develop markets for Licensed Products and Licensed Processes; and 

  

	 	(d)	until the date of first commercial sale of Licensed Products or Licensed Processes, it will supply UFRF with a written Development Report annually fifteen (15) days after the end of the calendar year (see Appendix
B). 

  
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 UFRF’s review of Licensee’s Development Plan and Development Report is solely to
verify the existence of Licensee’s commitment to development activity and to ensure compliance with Licensee’s obligations to commercialize the inventions of the Licensed Patents, as set forth above. 

 

	 	3.1.2	Licensee agrees that [**] shall occur on or before [**] of this Agreement or UFRF shall have the right to terminate the Agreement pursuant to Section 9.3 hereto. In addition, Licensee will meet the
milestones shown in Appendix D or UFRF shall have the right to terminate the Agreement pursuant to Section 9.3. Licensee will notify UFRF in writing as each milestone is met. 

 

	 	3.2	Upon written request by Licensee to negotiate extensions of the date of first commercial sale or any milestones or due dates set forth in Appendix D, such request to be received by UFRF no less than ninety
(90) days prior to any of the due dates subject of such request, set forth in this Section 3.13, such request fully describing Licensee’s diligent efforts to achieve the milestone required to be met by such due date, UFRF shall
consider in good faith such requests. Upon granting such request, UFRF and Licensee shall negotiate such extensions in good faith. 

  

	 	3.3	University of Florida policies may require approval of clinical trials at the University of Florida and involving technology invented at the University. Accordingly, Licensee will notify UFRF prior to commencing any
clinical trials at the University of Florida or its affiliated medical facilities. 

  

	Section 4	Payments 

  

	 	4.1	License Issue Fee 

 Licensee agrees to pay to UFRF a license issue fee of [**] within
thirty (30) days of the Effective Date. 
  

	 	4.2	Royalty 

 Royalty on Licensed Patents: Licensee agrees to pay to UFRF as earned royalties a
royalty calculated as a percentage of Net Sales. The royalty is deemed earned as of the earlier of the date the Licensed Product and/or Licensed Process is actually sold and paid for, the date an invoice is sent by Licensee or its Sublicensee(s), or
the date a Licensed Product and/or Licensed Process is transferred to a third party for any promotional reasons. Licensee shall pay to UFRF royalties as follows: 

(i) [**] for Net Sales of Licensed Products, for each Licensed Product, on a country-by-country basis, that is (a) covered in
whole or in part by an issued, unexpired claim or a pending claim contained in the Licensed Patents, in the country in which such Licensed Product is made, imported, exported, used or sold or (b) is manufactured using a Licensed Process which
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in part by an issued, unexpired claim or a pending claim contained in the Licensed Patents, in the country in which such Licensed Process is used. For clarification, only one royalty shall be due
with respect to the same unit of Licensed Product/ 
 (ii) [**] for Net Sales of Licensed Processes, for each Licensed Process, on a
country-by-country basis, that is covered in whole or in part by an issued, unexpired claim or a pending claim contained in the Licensed Patents in the country in which such process is practiced. 

(iii) [**] for Net Sales of Licensed Products, for each product, on a country-by-country basis, that is sold during a period of
regulatory exclusivity for such product in the country in which such product is sold. 
 (iv) [**] for Net Sales of all other
Licensed Products and Licensed Processes. 
 (v) In the event that licenses from third parties are required by Licensee in order to make,
have made, use, sell, offer to sell or import any particular Licensed Product or Licensed Process, then the earned royalty which Licensee is obligated to pay UFRF under this Section 4.3 shall be reduced by [**] for each one dollar
($1.00) in royalties which Licensee is pays to third parties under such licenses, further provided, however, that the royalties payable to UFRF under this Section 4.3 shall not be reduced to less than [**] of the applicable Net Sales.

 (vi) If a Licensed Product or Licensed Process is covered under another patent of UFRF, the rights to which have been licensed to the
Licensee by UFRF under any other license agreement and which license agreement calls for the payment of royalties or is covered under the NonExclusive License, duplicate royalties for the sales of such Licensed Products or Licensed Process shall not
be owed to UFRF by Licensee. Under such circumstances, the royalty calculation shall be made only once, even though the sale of the Licensed Product or Licensed Process may fall under more than one patent or more than one license agreement. If a
Licensed Product or Licensed Process is covered under another patent of UFRF, the rights to which have been licensed to Licensee by UFRF, or another license agreement, including the NonExclusive License, Licensee shall pay only the greatest of the
applicable royalty rates. 
 Royalties are payable for the longer of [**]. Royalties are payable based on the highest applicable rate
calculated per this section and such royalties based on Licensed Patents and Know-How shall not be additive. 
 Amounts owing to UFRF under
Sections 4.3 shall be paid on a quarterly basis after the amount of minimum royalties paid is exceeded, with such amounts due and received by UFRF on or before the thirtieth (30th) day
following the end of the calendar quarter ending on March 31, June 30, September 30 or December 31 in which such amounts were earned. 

  
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	 	4.3	Minimum Royalty 

  

	 	4.3.1	Licensee agrees to pay UFRF Minimum Royalty payments, as follows: 

  

			
	Payment	  	Year
	[**]	  	[**]

 and every year thereafter on the same date, for the life of this Agreement. 

The Minimum Royalty shall be paid in advance on a quarterly basis for each year in which this Agreement is in effect. The first Minimum
Royalty payment shall be due on December 31, 2012 and shall be in the amount of [**]. The Minimum Royalty for a given year shall be due in advance and shall be paid in quarterly installments on
March 31, June 30, September 30, and December 31 for the following quarter. Any Minimum Royalty paid in a calendar year will be credited against the earned royalties for that calendar year. It is understood that the
minimum royalties will be applied to earned royalties on a calendar year basis, and that sales of Licensed Products and/or Licensed Processes requiring the payment of earned royalties made during a prior or subsequent calendar year shall have no
effect on the annual Minimum Royalty due UFRF for other than the same calendar year in which the royalties were earned. 
  

	 	4.4	Milestone Payments 

 Licensee agrees to pay UFRF milestone payments within thirty
(30) days of the first achievement of such milestone, as follows: 
  

			
	 Payment
	  	 Event

		
	[**]	  	[**]
	[**]	  	[**]
	[**]	  	[**]
	[**]	  	[**]
	[**]	  	[**]

 If a Licensed Product or Licensed Process is covered under the NonExclusive License or another patent of UFRF,
the rights to which have been licensed to Licensee by UFRF and which license agreement calls for milestone payments for the same milestone event to be paid to UFRF as set forth above, duplicative milestone payments shall not be owed to UFRF by
Licensee with respect to a given Licensed Product or Licensed Process. Under such circumstances, the milestone payments shall be made only once, even though the development milestone may apply to more than one license. The. greater of the applicable
milestone shall be paid. 

  
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	 	4.5	Sublicense Fees 

 Licensee shall pay sublicense fees to UFRF per Section 2.2.2 of this
Agreement within thirty days (30) of the receipt of any such fees from Sublicensee. 
  

	 	4.6	Accounting for payments 

  

	 	4.6.1	Any amounts which remain unpaid after the date they are due to UFRF under this Section 4, Section 7, Section 2 or any other section of this Agreement shall accrue interest from the due date at the rate
equal to the lesser of (i) one and one-half percent (1.5%) per month or (ii) the maximum amount allowed under applicable law. However, in no event shall this interest provision be construed as a grant of permission for any payment
delays. Licensee shall also be responsible for repayment to UFRF of any attorney, collection agency, or other out-of-pocket UFRF expenses required to collect overdue payments due from this Section 4, Section 7, Section 2 or any other
applicable section of this Agreement. 

  

	 	4.6.2	Except as otherwise directed, all amounts owing to UFRF under this Agreement shall be paid in U.S. dollars to UFRF at the following address: 

University of Florida Research Foundation, Inc. 

223 Grinter Hall 
 PO Box 115500

 Gainesville, Florida 32611-5500 

Attention: Business Manager 

All monies owing stated in currencies other than U.S. dollars shall be converted at the rate shown in the Federal Reserve Noon Valuation Value
of Foreign Currencies on the day preceding the payment due date. 
 A certified full accounting statement showing how any amounts payable to
UFRF under Section 4.2 have been calculated shall be submitted to UFRF on the date of each such payment. Such accounting statements shall contain a written representation signed by an executive officer of Licensee that states that the
statements are true, accurate, and fairly represent all amounts payable to UFRF pursuant to this Agreement. Such accounting shall be on a per-country and product line, model or trade name basis and shall be summarized on the form shown In Appendix C
- UFRF Royalty Report of this Agreement. 
 In the event no payment is owed to UFRF because the amount of minimum royalties paid has not
been exceeded or otherwise, an accounting demonstrating that fact shall be supplied to UFRF. 
 UFRF is exempt from paying income taxes
under U.S. law. Therefore, all payments due under this Agreement shall be made without deduction for 

  
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taxes, assessments, or other charges of any kind which may be imposed on UFRF by any government outside of the United States or any political subdivision of such government with respect to any
amounts payable to UFRF pursuant to this Agreement. All such taxes, assessments, or other charges shall be assumed by Licensee. 
  

	Section 5	Certain Warranties and Disclaimer of UFRF 

  

	 	5.1	UFRF warrants that, except as otherwise provided under Section 17.1 of this Agreement with respect to U.S. Government interests, it is the owner of the Licensed Patents or otherwise has the right to grant the
licenses granted to Licensee in this Agreement. However, nothing in this Agreement shall be construed as: 

  

	 	5.1.1	a warranty or representation by UFRF as to the validity or scope of any right included in the Licensed Patents; 

  

	 	5.1.2	a warranty or representation that anything made, used, sold or otherwise disposed of under the license granted in this Agreement will or will not infringe patents of third parties; 

 

	 	5.1.3	an obligation to bring or prosecute actions or suits against third parties for infringement of Licensed Patents; 

  

	 	5.1.4	an obligation to furnish any services other than those specified in this Agreement; or 

  

	 	5.1.5	a warranty or representation by UFRF that it will not grant licenses to others to make, use or sell products not covered by the claims of the Licensed Patents which may be similar and/or compete with products made or
sold by Licensee. 

  

	 	5.2	EXCEPT AS OTHERWISE EXPRESSLY SET FORTH IN THIS AGREEMENT, UFRF MAKES NO REPRESENTATIONS AND EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO WARRANTIES OF MERCHANTABILITY,
FITNESS FOR A PARTICULAR PURPOSE, AND VALIDITY OF PATENT RIGHTS CLAIMS, ISSUED OR PENDING. UFRF ASSUMES NO RESPONSIBILITIES WHATSOEVER WITH RESPECT TO USE, SALE, OR OTHER DISPOSITION BY LICENSEE, ITS SUBLICBNSEE(S), OR THEIR VENDEES OR OTHER
TRANSFEREES OF PRODUCT INCORPORATING OR MADE BY USE OF INVENTIONS LICENSED UNDER THIS AGREEMENT. 

  
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	Section 6	Record Keeping 

  

	 	6.1	Licensee and its Sublicensee(s) shall keep books and records sufficient to verify the accuracy and completeness of Licensee’s and its Sublicensee(s)‘s accounting referred to above, including without
limitation, inventory, purchase and invoice records, manufacturing records, sales analysis, general ledgers, financial statements, and tax returns relating to the Licensed Products and/or Licensed Processes. Such books and records shall be preserved
for a period not less than six years after they are created or as required by federal law, both during and after the term of this Agreement. 

  

	 	6.2	Licensee and its Sublicensee shall take all steps necessary so that UFRF may, within thirty (30) days of its written request, audit, review and/or copy all of the books and records at a Single U.S. location to
verify the accuracy of Licensee’s and its Sublicensee(s)’s accounting. Such review may be performed by any authorized employees of UFRF as well as by any attorneys and/or accountants designated by UFRF, upon reasonable notice and during
regular business hours. If a deficiency with regard to any payment hereunder is determined, Licensee and its Sublicensee(s) shall pay the deficiency within thirty (30) days of receiving notice thereof along with applicable interest as described
in Section 4.6.1. If a royalty payment deficiency for a calendar year exceeds [**] of the royalties paid for that year, then Licensee and its Sublicensees shall be responsible for paying UFRF’s out-of-pocket expenses incurred with
respect to such review. 

  

	 	6.3	At any time during the term of this agreement, UFRF may request in writing that Licensee verify the calculation of any past payments owed to UFRF through the means of a self-audit. Within ninety (90) days of the
request, Licensee shall complete a self-audit of its books and records to verify the accuracy and completeness of the payments owed. Within thirty (30) days of the completion of the self-audit, Licensee shall submit to UFRF a report detailing
the findings of the self-audit and the manner in which it was conducted in order to verify the accuracy and completeness of the payments owed. If Licensee has determined through its self-audit that there is any payment deficiency, Licensee shall pay
UFRF the deficiency along with applicable interest under Section 4.6.1 with the submission of the self-audit report to UFRF. 

  

	Section 7	Patent Prosecution 

  

	 	7.1	UFRF shall prosecute and maintain the Licensed Patents using counsel of its choice. UFRF shall provide Licensee with copies of all documents sent to and received from the United States Patent and Trademark Office and
foreign patent offices relating to Licensed Patents. Licensee agrees to keep such information confidential. 

  

	 	7.2	Licensee shall pay to UFRF the sum of [**] within 30 days of the Effective Date to partially reimburse any and all expenses associated with preparation, filing, prosecution, issuance, maintenance, defense, and
reporting of the Licensed Patents incurred prior to the Effective Date 

  
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	 	7.3	Licensee shall be responsible for and pay [**] incurred by UFRF related to the preparation, filing, prosecution, issuance, maintenance, defense and reporting of the Licensed Patents subsequent to and separate of
those expenses cited in section 7.2 within thirty (30) days of receipt of an invoice from UFRF. It shall be the responsibility of Licensee to keep UFRF fully apprised of the “small entity” status of Licensee with respect to the U.S.
patent laws and with respect to the patent laws of any other countries, if applicable, and to inform UFRF of any changes In such status, within thirty days of any such change. 

 

	Section 8	Infringement and Invalidity 

  

	 	8.1	Licensee shall inform UFRF promptly in writing of any alleged infringement of the Licensed Patents by a third party and of any available evidence thereof. 

 

	 	8.2	During the term of this Agreement, UFRF shall have the right, but shall not be obligated, to prosecute at its own expense any such infringements of the Licensed Patents. If UFRF prosecutes any such infringement,
Licensee agrees that UFRF may include Licensee as a co-plaintiff in any such suit, without expense to Licensee. 

  

	 	8.3	If within six (6) months after having been notified of any alleged infringement, UFRF shall have been unsuccessful in persuading the alleged infringer to desist and shall not have brought an infringement action
against the alleged infringer, or if UFRF shall notify Licensee at any time prior thereto of its intention not to bring suit against the alleged infringer, then, and in those events only, Licensee shall have the right, but shall not be obligated, to
prosecute at its own expense any infringement of the Licensed Patents, only in the Licensed Fields as defined in in Section 1.10 of this Agreement, and Licensee may, for such purposes, use the name of UFRF, as party plaintiff. No settlement,
consent judgment or other voluntary final disposition of the suit may be entered into without the consent of UFRF, which consent shall not be unreasonably withheld. Licensee shall indemnify UFRF against any order for costs that may be made against
UFRF In such proceedings. 

  

	 	8.4	In the event that a declaratory judgment action is brought against UFRF or Licensee by a third party alleging invalidity, unpatentability, unenforceability, or non-infringement of the Licensed Patents, UFRF, at its
option, shall have the right within twenty (20) days after commencement of such action to take over the sole defense of the action at its own expense. If UFRF does not exercise this right, and assuming that Licensee is the sole licensee of the
Licensed Patents, Licensee shall be responsible for the sole defense of the action at Licensee’s sole expense, subject to Sections 8.5 and 8.6. 

  
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	 	8.5	In the event that Licensee shall undertake the enforcement by litigation and/or defense of the Licensed Patents by litigation, UFRF shall have the right, but not the obligation, to voluntarily join such litigation,
represented by its own counsel at its own expense. In the event that Licensee shall undertake the enforcement by litigation and/or defense of the Licensed Patents by litigation, any recovery of damages by Licensee for any such suit shall be applied
first in satisfaction of any unreimbursed expenses and legal fees of Licensee relating to the suit, and next toward reimbursement of UFRF for any legal fees, and unreimbursed expenses. The balance remaining from any such recovery shall be
[**]. 

  

	 	8.6	In any suit in which either party is involved to enforce or defend the Licensed Patents pursuant to this Agreement, the other party hereto shall, at the request and expense of the party initiating such suit, cooperate
in all respects and, to the extent possible, have its employees testify when requested and make available relevant records, papers, information, samples, specimens, and the like. 

 

	 	8.7	In the event Licensee contests the validity of any Licensed Patents, unless and until this Agreement terminates or expires, Licensee shall continue to pay royalties and make other payments pursuant to this Agreement
with respect to that patent as if such contest were not underway until the patent is adjudicated invalid or unenforceable by a court of last resort. 

  

	Section 9	Term and Termination 

  

	 	9.1	The term of this license shall begin on the Effective Date of this Agreement and continue until the later of the date that no Licensed Patent remains an enforceable patent and the date on which Licensee’s
obligation to pay royalties expires pursuant to Section 4.3 above. 

  

	 	9.2	Licensee may terminate this Agreement at any time by giving at least sixty (60) days written notice of such termination to UFRF. Such a notice shall be accompanied by a statement of the reasons for termination.

  

	 	9.3	UFRF may terminate this Agreement by giving Licensee at least sixty (60) days written notice if Licensee: 

  

	 	9.3.1	is delinquent on any report or payment 

  

	 	9.3.2	is not diligently developing and commercializing Licensed Products and Licensed Processes 

  

	 	9.3.3	is in breach of any provision of this Agreement 

  

	 	9.3.4	provides any false report 

  

	 	9.3.5	goes into bankruptcy, liquidation or has a receiver appointed to control any assets 

  
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	 	9.3.6	violates any laws or regulations of applicable government entities; or 

  

	 	9.3.7	shall cease to carry on its business pertaining to Licensed Patents. 

  

	 	9.3.8	If Licensee or any of its Affiliates brings a Patent Challenge against UFRF, or assists others in bringing a Patent Challenge against UFRF (except as required under a court order or subpoena), then UFRF may immediately
terminate this Agreement and/or the license granted hereunder. If a Sublicensee brings a Patent Challenge or assists another party in bringing a Patent Challenge (except as required under a court order or subpoena), then UFRF may send a written
demand to Licensee to terminate such sublicense. If Licensee fails to so terminate such sublicense within sixty (60) days after UFRF’s demand, UFRF may immediately terminate this Agreement and/or the license granted hereunder

  

	 	9.3.9	If payments of earned royalties under Section 4.2 once begun, cease for more than two (2) calendar quarters. 

Termination under this Section 9.3 will take effect sixty (60) days after written notice by UFRF unless Licensee remedies the
problem in that sixty (60) day period. 
  

	 	9.4	UFRF may immediately terminate this Agreement upon the occurrence of the second separate default by Licensee within any consecutive three-year period for failure to pay royalties, patent or any other expenses when due.

  

	 	9.5	Upon the termination of this Agreement for any reason, nothing herein shall be construed to release either party from any obligation that matured prior to the effective date of such termination. Licensee shall remain
obligated to provide an accounting for and to pay royalties earned to the date of termination, and any minimum royalties shall be prorated as of the date of termination by the number of days elapsed in the applicable calendar year. Licensee may,
however, after the effective date of such termination, sell all Licensed Products, and complete Licensed Products in the process of manufacture at the time of such termination and sell the same, provided that Licensee shall remain obligated to
provide an accounting for and to pay running royalties thereon. 

  

	Section 10	Assignability 

  

	 	10.1	 This Agreement may not be transferred or assigned by Licensee except with the prior written consent of UFRF, which shall not be unreasonably withheld;
and provided that Licensee may assign any of its rights under this Agreement in any country to any Affiliates and may delegate its obligations under this Agreement in any country to any Affiliates; provided, however, that such assignment shall not
relieve Licensee of its responsibilities for performance of its obligations under this Agreement. Licensee may assign all of its rights and obligations under this Agreement in connection with a merger or similar reorganization or the sale of all or
substantially all of the assets and or stock of the Licensee. This Agreement 

  
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shall survive any such merger or reorganization of Licensee within, or into, or such sale of assets and/or stock to, another party, and no consent for such merger, reorganization or sale shall be
required hereunder., Licensee shall provide UFRF written notice of assignment within thirty (30) days of the effective date of such assignment. Any attempted assignment in contravention of this Section 10.1 shall be null and void and shall
constitute a material breach of this Agreement. 

  

	 	10.2	The new assignee shall assume all responsibilities under this Agreement and must agree in writing to UFRF to be bound by this Agreement. 

 

	Section 11	Dispute Resolution Procedures 

  

	 	11.1	Mandatory Procedures 

 In the event either party intends to file a lawsuit against the other
with respect to any matter in connection with this Agreement, compliance with the procedures set forth in this Section shall be a condition precedent to the filing of such lawsuit, other than for injunctive relief Either party may terminate this
Agreement as provided in this Agreement without following the procedures set forth in this section. 
  

	 	11.1.1	When a party intends to invoke the procedures set forth in this section, written notice shall be provided to the other party. Within thirty (30) days of the date of such notice, the parties agree that
representatives designated by the parties shall meet at mutually agreeable times and engage in good faith negotiations at a mutually convenient location to resolve such dispute. 

 

	 	11.1.2	If the parties fail to meet within the time period set forth in Section 11.1.1 above or if either party subsequently determines that negotiations between the representatives of the parties are at an impasse, the
party declaring that the negotiations are at an impasse shall give notice to the other party stating with particularity the issues that remain in dispute. 

  

	 	11.1.3	Not more than fifteen (15) days after the giving of such notice of issues, each party shall deliver to the other party a list of the names and addresses of at least three individuals, any one of whom would be
acceptable as a neutral advisor in the dispute (the “Neutral Advisor”) to the party delivering the list. Any individual proposed as a Neutral Advisor shall have experience in determining, mediating, evaluating, or trying intellectual
property litigation and shall not be affiliated with the party that is proposing such individual. 

  

	 	11.1.4	Within ten (10) days after delivery of such lists, the parties shall agree on a Neutral Advisor. If they are unable to so agree within that time, within five (5) days, they shall each select one individual
from the lists. Within five (5) days, the individuals so selected shall meet and appoint a third individual from the lists to serve as the Neutral Advisor. Within thirty (30) days after the selection of a Neutral Advisor:

  

	 	(a)	The parties shall each provide a written statement of the issues In dispute to the Neutral Advisor. 

  
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	 	(b)	The parties shall meet with the Neutral Advisor in Gainesville, Florida on a date and time established by the Neutral Advisor. The meeting must be attended by persons authorized to make final decisions on behalf of each
party with respect to the dispute. At the meeting, each party shall make a presentation with respect to its position concerning the dispute. The Neutral Advisor will then discuss the issues separately with each party and attempt to resolve all
issues in the dispute. At the meeting, the parties will enter into a written settlement agreement with respect to all issues that are resolved. Such settlement agreement shall be final and binding with respect to such resolved issues and may not be
the subject of any lawsuit between the parties, other than a suit for enforcement of the settlement agreement. 

  

	 	11.1.5	The expenses of the neutral advisor shall be shared by the parties equally. All other out-of-pocket costs and expenses for the alternative dispute resolution procedure required under this Section shall be paid by the
party incurring the same. 

  

	 	11.1.6	Positions taken and statements made during this alternative dispute resolution procedure shall be deemed settlement negotiations and shall not be admissible for any purpose in any subsequent proceeding.

  

	 	11.2	Failure to Resolve Dispute 

 If any issue is not resolved at the meeting with the Neutral
Advisor, either party may file appropriate administrative or judicial proceedings with respect to the issue that remains in dispute. No new issues may be included in the lawsuit without the mandatory procedures set forth in this section having first
been followed. 
  

	 	11.3	Survival. 

 The provisions of this Section shall survive termination of this Agreement. 

 

	Section 12	Product Liability; Conduct of Business 

  

	 	12.1	 Licensee and its Sublicensee(s) shall, at all times during the term of this Agreement and thereafter, indemnify, defend and hold UFRF, the Florida
Board of Governors, the University of Florida Board of Trustees, the University of Florida, and each of their directors, officers, employees, and agents, and the inventors of the Licensed Patents, regardless of whether such inventors are

  
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employed by the University of Florida at the time of the claim, harmless against all claims and expenses, including legal expenses and reasonable attorneys’ fees, whether arising from a
third party claim or resulting from UFRF’s enforcing this indemnification clause against Licensee, arising out of the death of or injury to any person or persons or out of any damage to property and against any other claim, proceeding, demand,
expense and liability of any kind whatsoever resulting from the development, production, manufacture, sale, use, lease, consumption, marketing, or advertisement of Licensed Products or Licensed Process(es) or arising from any right or obligation of
Licensee hereunder. Notwithstanding the above, UFRF at all times reserves the right to retain counsel of its own to defend UFRF’s, the Florida Board of Governors’, the University of Florida Board of Trustees’, the University of
Florida’s, and the inventor’s interests. 

  

	 	12.2	Licensee warrants that it now maintains and will continue to maintain liability insurance coverage appropriate to the risk involved in development, producing, manufacturing, clinical trials, selling, marketing, using,
leasing, consuming, or advertising the products subject to this Agreement and that such insurance coverage lists UFRF, the Florida Board of Governors, the University of Florida Board of Trustees, the University of Florida, and the inventors of the
Licensed Patents as additional insureds. Within ninety (90) days after the execution of this Agreement and thereafter annually between January 1 and January 31 of each year, Licensee will present evidence to UFRF that the coverage is
being maintained with UFRF, the University of Florida, and its inventors listed as additional insureds. In addition, Licensee shall provide UFRF with at least thirty (30) days prior written notice of any change in or cancellation of the
insurance coverage. 

  

	Section 13	Use of Names 

 Licensee and its Sublicensee(s) shall not use the names of UFRF,
or of the University of Florida, nor of any of either institution’s employees, agents, or affiliates, nor the name of any inventor of Licensed Patents, nor any adaptation of such names, in any promotional, advertising or marketing materials or
any other similar form of publicity, or to suggest any endorsement by such entitles or individuals, without the prior written approval of UFRF in each case. 
  

	Section 14	14 Miscellaneous 

  

	 	14.1	This Agreement shall be construed in accordance with the Internal laws of the State of Florida 

  

	 	14.2	The parties hereto are independent contractors and not joint venturers or partners. 

  

	 	14.3	Licensee shall ensure that it applies patent markings that meet all requirements of U.S. law, 35 U.S.C. §287, with respect to all Licensed Products subject to this Agreement. 

  
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	 	14.4	This Agreement constitutes the full understanding between the parties with reference to the subject matter hereof, and no statements or agreements by or between the parties, whether orally or in writing, shall vary or
modify the written terms of this Agreement. Neither party shall claim any amendment, modification, or release from any provisions of this Agreement by mutual agreement, acknowledgment, or otherwise, unless such mutual agreement is in writing, signed
by the other party, and specifically states that it is an amendment to this Agreement. 

  

	 	14.5	Licensee shall not encumber or otherwise grant a security in any of the rights granted hereunder to any third party. 

  

	 	14.6	Licensee acknowledges that it is subject to and agrees to abide by the United States laws and regulations (including the Export Administration Act of 1979 and Arms Export Control Act) controlling the export of technical
data, computer software, laboratory prototypes, biological material, and other commodities. The transfer of such items may require license from the cognizant agency of the U.S. Government or written assurances by Licensee that it shall not export
such items to certain foreign countries and/or foreign persons without prior approval of such agency. UFRF neither represents that a license is or is not required or that, if required, it shall be issued. 

 

	 	14.7	Licensee is responsible for any and all wire/bank fees associated with all payments due to UFRF pursuant to this agreement. 

  

	 	14.8	Survival 

 The provisions of this Section shall survive termination of this Agreement. Upon
termination of the Agreement for any reason, the following sections of the License Agreement will remain in force as non-cancelable obligations: 
  

			
	 •       Section 6
	    	Record Keeping
		
	 •       Section 9
	    	Requirement to pay royalties on sale of Licensed Products made, and in process, at the time of License Agreement termination
		
	 •       Section 12
	    	Product Liability; Conduct of Business
		
	 •       Section 13
	    	Use of Nantes
		
	 •       Section 18
	    	Confidentiality

  

	Section 15	Notices 

 Any notice required to be given pursuant to the provisions of this
Agreement shall be in writing and shall be deemed to have been given 
  

	 	•	 	when delivered personally, or 

  

	 	•	 	 if sent by facsimile transmission, when receipt thereof is acknowledged at the facsimile number of the recipient as set forth below, or

  
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	 	•	 	the second day following the day on which the notice has been delivered prepaid to a courier service, or 

  

	 	•	 	five (5) business days following deposit in the U.S. mail if sent certified mail, (return receipt acknowledgement is not required to certify delivery). 

 

	 	15.1	If to the University of Florida Research Foundation, Inc.: 

 President 

University of Florida Research Foundation, Inc. 

223 Grinter Hall 
 University of
Florida 
 Post Office Box 115500 

Gainesville, FL 32611-5500 

Facsimile Number: 352-846-0505 

with a copy to: 
 Office of
Technology Licensing 
 Attn: Director 

747 SW Second Avenue 

University of Florida 
 Post
Office Box 115575 
 Gainesville, Florida 32611-5575 

Facsimile Number: 352-392-6600 
  

	 	15.2	If to Licensee: 

 Sue Washer, CEO 

Applied Genetic Technologies Corporation 

11801 Research Drive, Suite D 

Alachua, FL 32615 
 Facsimile
Number 386.462-0875 
 With a copy to 

Fred Hutchison 
 Hutchison Law
Group 
 5410 Trinity Road 

Suite 400 
 Raleigh, North
Carolina 27607 
  

	Section 16	Contract Formation and Authority 

 The submission of this Agreement does not
constitute an offer, and this document shall become effective and binding only upon the execution by duly authorized representatives of both Licensee and UFRF. Copies of this Agreement that have not been executed and delivered by both UFRF and
Licensee shall not serve as a memorandum or other writing evidencing an agreement between the parties. This Agreement shall automatically terminate and be of no further force and effect, 

  
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without the requirement of any notice from UFRF to Licensee, if UTRF does not receive the License Issue Fee or certificates representing shares issued to UFRF pursuant to this Agreement, as
applicable, within thirty (30) days of the Effective Date. 
  

	 	16.1	UFRF and Licensee hereby warrant and represent that the persons signing this Agreement have authority to execute this Agreement on behalf of the party for whom they have signed. 

 

	 	16.2	Force Majeure 

 No default, delay, or failure to perform on the part of Licensee or UFRF shall
be considered a default, delay or failure to perform otherwise chargeable hereunder, if such default, delay or failure to perform is due to causes beyond either party’s reasonable control including, but not limited to strikes, lockouts, or
inactions of governmental authorities, epidemics, war, embargoes, fire, earthquake, hurricane, flood, acts of God, or default of common carrier. In the event of such default, delay or failure to perform, any date or times by which either party is
otherwise scheduled to perform shall be extended automatically for a period of time equal in duration to the time lost by reason of the excused default, delay or failure to perform. 

 

	Section 17	United States Government Interests 

  

	 	17.1	It is understood that the United States Government (through any of its agencies or otherwise) has funded research, [**], during the course of or under which any of the inventions of the Licensed Patents were conceived
or made. The United States Government is entitled, as a right, under the provisions of 35 U.S.C. §202-212 and applicable regulations of Title 37 of the Code of Federal Regulations, to a non-exclusive, nontransferable, irrevocable, paid-up
license to practice or have practiced the inventions of such Licensed Patents for governmental purposes. Any license granted to Licensee in this Agreement shall be subject to such right. 

 

	 	17.2	Licensee agrees that for Licensed Products covered by the Licensed Patents that are subject to the non-exclusive royalty-free license to the United States Government, said Licensed Products will be manufactured
substantially in the United States. Licensee further agrees that it shall abide by all the requirements and limitations of U.S. Code, Title 35, Chapter 18, and implementing regulations thereof, for all patent applications and patents invented in
whole or in part with federal money. 

  

	Section 18	Confidentiality 

 18.1 Each Party shall maintain all information of the other
Party which is treated by such other Party as proprietary or confidential (referred to herein as “Confidential Information”) in confidence, and shall not disclose, divulge or otherwise communicate such confidential information

  
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to others, or use it for any purpose, except pursuant to, and in order to carry out, the terms and objectives of this Agreement, and each party hereby agrees to exercise every reasonable
precaution to prevent and restrain the unauthorized disclosure of such confidential information by any of its Affiliates, directors, officers, employees, consultants, subcontractors, Sublicensees or agents. Licensees Confidential Information
includes but is not limited to the Development Plan, Development Reports and all other financial, research, development or business reports, strategies and agreements, including Sublicenses, of Licensee. The parties agree to keep the terms of this
Agreement confidential, provided that each party may disclose this Agreement to their authorized agents and investors who are bound by similar confidentiality provisions. Notwithstanding the foregoing, Confidential Information of a party shall not
include information which: (a) was lawfully known by the receiving party prior to disclosure of such information by the disclosing party to the receiving party; (b) was or becomes generally available in the public domain, without the fault
of the receiving party; (c) is subsequently disclosed to the receiving party by a third party having a lawful right to make such disclosure; (d) is required by law, rule, regulation or legal process to be disclosed, provided that the
receiving party making such disclosure shall take all reasonable steps to restrict and maintain to the extent possible confidentiality of such disclosure and shall provide reasonable notice to the other party to allow such party the opportunity to
oppose the required disclosure; or (e) has been Independently developed by employees or others on behalf of the receiving party without access to or use of disclosing party’s information as demonstrated by written record. Each party’s
obligations under this Section 18 shall extend for a period of five (5) years from termination or expiration of this Agreement. 
  

	Section 19	University Rules and Regulations 

 19.1 Licensee understands and agrees that
University of Florida personnel who are engaged by Licensee, whether as consultants, employees or otherwise, or who possess a material financial interest in Licensee, are subject to the University of Florida’s rule regarding outside activities
and financial interests set forth in Florida Administrative Code Rule 6C1-1.011, the University of Florida’s Intellectual Property Policy, and a monitoring plan which addresses conflicts of interests associated therewith. Any term or condition
of an agreement between Licensee and such University of Florida personnel which seeks to vary or override such personnel’s obligations to the University of Florida may not be enforced against such personnel, the University of Florida or UFRF,
without the express written consent of an individual authorized to vary or waive such obligations on behalf of the University of Florida and UFRF. Furthermore, should an interest of Licensee conflict with the interest of the University of Florida,
University of Florida personnel are obligated to resolve such conflicts according to the guidelines and policies set forth by the University of Florida. 

  
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 IN WITNESS WHEREOF, the parties hereto have duly executed this Agreement on the dates indicated below. UNIVERSITY
OF FLORIDA RESEARCH FOUNDATION, INC. 
 UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. 

 

							
	 /s/ David L. Day
	 		 	Date:	 	11/7, 2012
	David L. Day	 		 		 	
	Director of Technology Licensing	 		 		 	

 LICENSEE 
 APPLIED
GENETIC TECHNOLOGIES CORPORATION 
  

									
	By:	 	 /s/ Susan B. Washer
	 		 	Date:	 	11/12, 2012
	Susan B. Washer, President and CEO	 		 		 	

  
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 Appendix A - Development Plan 

A Development Plan of the scope outlined below shall be submitted to UFRF by Licensee prior to the execution of this agreement. In general, the plan should
provide UFRF with a summary overview of the activities that Licensee believes are necessary to bring products to the marketplace. 
 Development Program

 Development activities to be undertaken 
 [**] 

Proposed Market Approach 
 [**] 

Competitive Information 
 [**] 

  
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Page 1 

 Appendix B - Development Report 

When appropriate, indicate estimated start date and finish date for activities. 

Date Development Plan Initiated and Time Period Covered by this Report. 

Development Report (4-8 paragraphs). 
 Activities completed
since last report including the object and parameters of the development, when initiated, when completed and the results. 
 Activities currently under
investigation, i.e., ongoing activities including object and parameters of such activities, when initiated, and projected date of completion. 
 Future
Development Activities (4-8 paragraphs). 
 Activities to be undertaken before next report including, but not limited to, the type and object of any studies
conducted and their projected starting and completion dates. 
 Estimated total development time remaining before a product will be commercialized. 

One year before commencement of manufacturing or commercial production, Licensee will include in the Development Report specifics of planned manufacturing or
production 
 Changes to Initial Development Plan (2-4 paragraphs). 

Reasons for change. 
 Variables that may cause additional
changes. 
 Items to be Provided if Applicable: 
 Information
relating to Licensed Products that has become publicly available, e.g., published articles, competing products, patents, etc. 
 Development work being
performed by third parties, other than Licensee, to include name of third party, reasons for use of third party, planned future uses of third parties including reasons why and type of work. 

Update of competitive information trends in industry, government compliance (if applicable) and market plan. 

Information and copies of relevant materials evidencing the status of any patent applications or other protection relating to Licensed Products or the
Licensed Patents. 
 One year before commencement of manufacturing or commercial production, Licensee will include in the Development Report specifics of
planned manufacturing or production. 
 PLEASE SEND DEVELOPMENT REPORTS TO: 

  University of Florida Research Foundation, Inc. 

  Attn: Director 

  The Innovation Hub 

747 SW Second Avenue 

  P.O. Box 115575 

  Gainesville, FL 32611-5575 

  Facsimile: 352-392-6600 

  
 Initials
                         

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 Appendix C - UFRF Royalty Report 

 

					
	Company Name:	  	  
	  	

 If multiple license agreements are required to generate this product, indicate what percentage of the royalty is attributable
to each agreement. 
  

											
	UFRF Agreement No.:	 	  
	    	Percentage:	  	  
	  	
	UFRF Agreement No.:	 	  
	    	Percentage:	  	  
	  	
	Period Covered: From:	 	     /    /2
	    	 Through:
	  	     /    /2
	  		  	

  

									
	Prepared By:	 	  
	  		  	Date:	  	  

							
	Print Preparer Name:	 		  		  	

  

											
	Preparer Email Address:	 	  
	  		  	Phone No.:	  	  
	  	

  

									
	Approved By:	  	  
	  	Date:	  	  
	  	
		  	(Requires Executive Officer Signature)	  		  		  	

 Print Officer Name: 
 If
license covers multiple product lines, please prepare a separate spreadsheet for each product line, and a summary report for all products combined. 
 The
spreadsheet should include the following information: 
  

	 	•	 	Product Name 

  

	 	•	 	Country(ies) of Sales (List each country. If royalties vary by country, provide a breakdown of specified information for each country.) 

 

	 	•	 	Unit Sales 

  

	 	•	 	Gross Sales 

  

	 	•	 	Less Allowances (On a separate page, please indicate the reasons for returns or other adjustments if significant.) 

  

	 	•	 	Net Sales 

  

	 	•	 	Royalty Rate (Please note any unusual occurrences that affected royalty amounts during this period. To assist UFRF’s forecasting, please comment on any market variables that would impact future royalties).

  

	 	•	 	Total Royalty due this period 

  

	 	•	 	Total Royalty paid last period 

  
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 Appendix D - Milestones 

 

	1.	Licensee has already provided UFRF a preliminary Development Plan. Within six months of execution of this license, Licensee will provide UFRF a detailed document covering Licensee’s plans as to projected product
development, markets and sales forecasts, manufacturing and operations, and financial forecasts (“Business Plan”). UFRF will treat this Business Plan as confidential information and to protect it as UFRF would its own confidential
information. 

 [**] 

  
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