Document:

Exhibit 10.1

  

  
    

    

    INDEMNIFICATION AGREEMENT

     

    THIS AGREEMENT (the “Agreement”) is
      made and entered into as of [date] between Catalyst Biosciences, Inc., a Delaware corporation (the “Company”), and [name of director], a director, officer or member of the
      executive committee of the Company (“Indemnitee”).

     

    WITNESSETH THAT:

     

    WHEREAS, Indemnitee performs a valuable service for the Company; and

     

    WHEREAS, the Board of Directors of the Company (the “Board”) has adopted bylaws (the “Bylaws”) providing for or permitting the indemnification of officers, directors and employees of the Company to the fullest
      extent permitted by the Delaware General Corporation Law, as amended (the “DGCL”); and

     

    WHEREAS, the Bylaws and the DGCL, by their nonexclusive nature, permit agreements between the Company and its
      officers, directors and employees with respect to indemnification; and

     

    WHEREAS, in order to induce Indemnitee to continue to serve as a director, officer or member of the executive
      (management) committee of the Company, the Company has agreed to enter into this agreement with Indemnitee;

     

    NOW, THEREFORE, in consideration of Indemnitee’s continued service as a director, officer or member of the
      executive committee of the Company after the date hereof, the parties agree as follows:

     

    1.          Definitions. For purposes of this Agreement:

     

    (a)          “Change of Control” means:

     

    (i)          The acquisition by any Person of beneficial ownership (within the meaning of Rule 13d-3 promulgated under the Exchange Act) of twenty percent (20%) or more of (A) the then outstanding shares of common stock of the Company
          (the “Outstanding Company Common Stock”) or (B) the combined voting power of the then outstanding voting securities of the Company entitled to vote generally in the election
          of directors (the “Outstanding Company Voting Securities”); provided that, notwithstanding the foregoing, none of the following acquisitions shall constitute a Change of
          Control: (1) an acquisition directly from the Company or from other stockholders that (x) was approved in advance by the Board and (y) would not constitute a Change of Control under Section 1(a)(iii); (2) an acquisition by the Company; (3) an
          acquisition by an employee benefit plan (or related trust) sponsored or maintained by the Company or any entity controlled by, or under common control with, the Company; or (4) an acquisition by an entity with respect to which the criteria set
          forth in Section 1(a)(iii)(A), (B) and (C) are met; or

     

        

    
      

      
        

      

    

    (ii)          Consummation of a reorganization, merger or consolidation or sale or other disposition of all or substantially all of the assets of the Company (a “Business Combination”); provided that, notwithstanding the foregoing, a Business Combination shall not constitute a Change of Control if: (A) the individuals and entities who are the
          beneficial owners of the Outstanding Company Common Stock and Outstanding Company Voting Securities, respectively, immediately prior to such Business Combination beneficially own, directly or indirectly, more than fifty percent (50%) of the then
          outstanding shares of common stock and of the combined voting power of the then outstanding voting securities entitled to vote generally in the election of directors of the resulting, continuing or surviving entity in such Business Combination
          (including, if applicable, an entity that, as a result of such transaction, owns the Company or all or substantially all of the Company’s assets either directly or through one or more subsidiaries) in substantially the same proportion as existed
          immediately prior to such Business Combination; (B) no Person (excluding the resulting, continuing or surviving entity in such Business Combination or any employee benefit plan (or related trust) of such resulting, continuing or surviving entity)
          beneficially owns, directly or indirectly, twenty percent (20%) or more of the then outstanding shares of common stock or of the combined voting power of the then outstanding voting securities of the resulting, continuing or surviving entity in
          such Business Combination, except to the extent that such ownership existed prior to the Business Combination; and (C) at least a majority of the members of the board of directors of the resulting, continuing or surviving entity in such Business
          Combination are members of the Board at the time of the execution of the definitive agreement providing for such Business Combination or of its authorization and approval by the Board; or

     

    (iii)          Approval by the stockholders of the Company of a complete liquidation or dissolution of the Company.

     

    (b)          “Company Position” means the status of a person as a present or former director, officer, employee or agent of the Company or any other Enterprise.

     

    (c)          “Disinterested Director” means a director of the Company who is not and was not a party to the matter in respect of which indemnification or
          advancement of Expenses is sought by Indemnitee.

     

    (d)          “Enterprise” shall mean the Company or any other corporation, partnership, joint venture, trust, employee benefit plan or other enterprise for which
          Indemnitee serves, or did serve, at the request of the Company as a director, officer, employee or agent.

     

    (e)          “Exchange Act” means the Securities Exchange Act of 1934, as amended.

     

    (f)          “Expenses” shall include all judgments, fines, ERISA excise taxes or penalties, amounts paid in settlement, reasonable attorneys’ fees, retainers, court costs, transcript costs,
          fees of experts, witness fees, travel expenses, duplicating costs, printing and binding costs, telephone charges, postage, delivery service fees and all other disbursements or expenses of a type customarily incurred in connection with
          prosecuting, defending, preparing to prosecute or defend, investigating, participating in, or being or preparing to be a witness in a Proceeding.

     

    (g)          “Independent Counsel” means a law firm, a partner or member of a law firm or an independent practitioner who (i) is experienced in matters of corporate
          law and

     

    
      

      
        

      

    

    (ii) would not, under the applicable standards of professional conduct then prevailing, have a conflict of interest in
      representing either the Company or the Indemnitee in an action to determine the Indemnitee’s rights under this Agreement.

     

    (h)          “Person” means any individual, entity or group (within the meaning of Section 13(d)(3) or 14(d)(2) of the Exchange Act).

     

    (i)          “Proceeding” includes any threatened, pending or completed action, suit, arbitration, alternate dispute resolution mechanism, investigation, inquiry, administrative hearing or
          any other actual, threatened or completed proceeding in which Indemnitee was, is or will be involved as a party or otherwise, whether brought by or in the right of the Company or

    otherwise, whether civil, criminal, administrative or investigative, whether pending before or after the date of this Agreement and whether or not he
      is acting or serving in any such capacity at the time any liability or expense is incurred for which indemnification can be provided under this Agreement, but specifically excluding an action initiated by an Indemnitee pursuant to Section 8 to
      enforce his rights under this Agreement.

     

    2.          Indemnity of Indemnitee. The Company hereby agrees to indemnify and hold harmless Indemnitee to the fullest extent permitted by the provisions of the DGCL, as may
          be amended from time to time. Without limiting the generality of the foregoing:

     

    (a)          Proceedings Other Than Proceedings by or in the Right of the Company. If Indemnitee was, is or is threatened to be made a party to, or a participant
          in, any Proceeding (other than a Proceeding by or in the right of the Company) by reason of his Company Position, the Company shall indemnify him against all Expenses actually and reasonably incurred by him, or on his behalf, in connection with
          such Proceeding (including, without limitation, any claim, issue or matter included therein) if he acted in good faith and in a manner he reasonably believed to be in, or not opposed to, the best interests of the Company, and with respect to any
          criminal Proceeding, had no reasonable cause to believe his conduct was unlawful.

     

    (b)          Proceedings by or in the Right of the Company. If Indemnitee was, is or is threatened to be made a party to, or a participant in, any Proceeding by or
          in the right of the Company by reason of his Company Position, the Company shall indemnify him against all Expenses actually and reasonably incurred by him, or on his behalf, in connection with the defense or settlement of such Proceeding if he
          acted in good faith and in a manner he reasonably believed to be in, or not opposed to, the best interests of the Company; provided, however, if required by applicable law, no indemnification against such Expenses shall be made in respect of any
          claim, issue or matter in such Proceeding as to which Indemnitee shall have been adjudged to be liable to the Company unless and to the extent that the Court of Chancery of the State of Delaware shall determine that such indemnification may be
          made.

     

        

    (c)          Indemnification for Expenses of a Party who is Wholly or Partially Successful. Notwithstanding any other provision of this
          Agreement, to the extent that

    Indemnitee is, by reason of his Company Position, a party to, and is successful in defending (on the merits or otherwise), any
      Proceeding, the Company shall indemnify him to the maximum extent permitted by law against all Expenses actually and reasonably incurred by him, or on his behalf, in connection therewith. If Indemnitee is not wholly successful in such Proceeding but
      is successful, on the merits or otherwise, as to one or more but less than all claims, issues or matters in such Proceeding, the Company shall indemnify Indemnitee against all Expenses actually and reasonably incurred by him or on his behalf in
      connection with each successfully resolved claim, issue or matter. For purposes of this Section 2(c) and without limitation, the termination of any claim, issue or matter in such a Proceeding by dismissal, with or without prejudice, shall be deemed
      to be a successful result as to such claim, issue or matter.

     

    

    
      

      
        

      

    

    3.          Additional Indemnity. In addition to, and without regard to any limitations on, the indemnification provided for in Section 2, the Company shall indemnify and hold
          harmless Indemnitee against all Expenses actually and reasonably incurred by him or on his behalf if, by reason of his Company Position, he was, is or is threatened to be made, a party to, or participant in, any Proceeding (including a Proceeding
          by or in the right of the Company), including, without limitation, all liability arising out of the negligence or active or passive wrongdoing of Indemnitee. The only limitation that shall exist upon the Company’s obligations pursuant to this
          Agreement, other than those specified in Section 12, shall be that the Company shall not be obligated to make any payment to Indemnitee that is finally determined (under the procedures, and subject to the presumptions, set forth in Sections 7 and
          8) to be unlawful under Delaware law.

     

    4.          Contribution in the Event of Joint Liability.

     

    (a)          Whether
          or not the indemnification provided in Sections 2 and 3 is available, in respect of any Proceeding in which the Company is jointly liable with Indemnitee (or would be if joined in such Proceeding), the Company shall pay, in the first instance,
          the entire amount of any judgment or settlement of such Proceeding without requiring Indemnitee to contribute to such payment and the Company hereby waives and relinquishes any right of contribution it may have against Indemnitee. The Company
          shall not enter into any settlement of any Proceeding in which the Company is jointly liable with Indemnitee (or would be if joined in such Proceeding) unless such settlement provides for a full and final release of all claims asserted against
          Indemnitee.

     

    (b)          Without
          diminishing or impairing the obligations of the Company set forth in Section 4(a), if, for any reason, Indemnitee shall elect or be required to pay all or any portion of any judgment or settlement in any Proceeding in which the Company is jointly
          liable with Indemnitee (or would be if joined in such Proceeding), the Company shall contribute to the amount of Expenses actually and reasonably incurred and paid or payable by Indemnitee in proportion to the relative benefits received by the
          Company and all officers, directors or employees of the Company, other than Indemnitee, who are jointly liable with Indemnitee (or would be if joined in such Proceeding), on the one hand, and Indemnitee, on the other hand, from the transaction
          from which such Proceeding arose; provided, however, that the proportion determined on the basis of relative benefit may, to the extent required by law, be further adjusted by reference to the relative fault of the Company and all officers,
          directors or employees of the Company other than Indemnitee who are jointly liable with Indemnitee (or would be if joined in such Proceeding), on the one hand, and Indemnitee, on the other hand, in connection with the events that resulted in such
          Expenses, as well as any other equitable considerations which are required to be considered under applicable law. The relative fault of the Company and all officers, directors or employees of the Company, other than Indemnitee, who are jointly
          liable with Indemnitee (or would be if joined in such Proceeding), on the one hand, and Indemnitee, on the other hand, shall be determined by reference to, among other things, the degree to which their respective actions were motivated by intent
          to gain personal profit or advantage, the degree to which their liability is primary or secondary and the degree to which their conduct is active or passive.

     

    
      

      
        

      

    

    (c)          The Company shall fully indemnify and hold harmless Indemnitee from any claims of contribution that may be brought by any one or more officers, directors or employees of the Company, other than Indemnitee, who may be jointly
          liable with Indemnitee.

     

    5.          Indemnification for Expenses of a Witness. Notwithstanding any other provision of this Agreement, to the extent that Indemnitee is, by reason of his Company Position, a witness in any
          Proceeding to which Indemnitee is not a party, he shall be indemnified against all Expenses actually and reasonably incurred by him or on his behalf in connection therewith.

     

    6.          Advancement of Expenses. Notwithstanding any other provision of this Agreement, the Company shall advance all Expenses
          incurred in connection with any Proceeding by or on behalf of Indemnitee by reason of his Company Position within twenty (20) calendar days after the receipt by the Company of a statement or statements from Indemnitee requesting such advance or
          advances from time to time, whether prior to or after final disposition of such Proceeding; provided that: (i) no determination has been made that the facts then known would preclude indemnification pursuant to the terms of this Agreement; and
          (ii) Indemnitee (A) affirms in such written request that he acted in good faith and in a manner which he reasonably believed to be in, or not opposed to, the best interests of the Company (and, in the case of a criminal Proceeding,
      that he had no reasonable cause to believe his conduct was unlawful), (B) undertakes in such written request to repay such amount to the extent that it is ultimately determined that Indemnitee is not entitled to be indemnified against such Expenses
      and (C) provides appropriate supporting documentation for the Expenses for which he is seeking indemnification. Any advances and undertakings to repay pursuant to this Section 6 shall be unsecured and interest free. Notwithstanding the foregoing, the
      obligation of the Company to advance Expenses pursuant to this Section 6 shall be subject to the condition that, if, when and to the extent that the Company determines that Indemnitee would not be permitted to be indemnified under applicable law, the
      Company shall be entitled to be reimbursed by Indemnitee (who hereby expressly agrees to reimburse the Company) within thirty (30) days of such determination for all such amounts theretofore paid; provided, however, that if Indemnitee has commenced
      or thereafter commences legal proceedings in a court of competent jurisdiction to secure a determination that Indemnitee should be indemnified under applicable law, any determination made by the Company that Indemnitee would not be permitted to be
      indemnified under applicable law shall not be binding and Indemnitee shall not be required to reimburse the Company for any advance of Expenses until a final judicial determination is made with respect thereto (and as to which all rights of appeal
      therefrom have been exhausted or lapsed).

     

    7.          Procedures and Presumptions for Determination of Entitlement to Indemnification. It is the intent of this Agreement to secure for Indemnitee rights of indemnity
          that are as favorable as may be permitted under the DGCL and public policy of the State of Delaware. Accordingly, the parties agree that the following procedures and presumptions shall apply
          in the event of any question as to whether Indemnitee is entitled to indemnification under this Agreement:

     

    (a)          To obtain indemnification under this Agreement (including, without limitation, the advancement of Expenses and contribution by the Company), Indemnitee shall submit to the Company a written request,
          including therein or therewith such documentation and information as is reasonably available to Indemnitee and is reasonably necessary to determine whether and to what extent Indemnitee is entitled to indemnification. The Secretary of the Company
          shall, promptly upon receipt of such a request for indemnification, advise the Board in writing that Indemnitee has requested indemnification.

     

        

    
      

      
        

      

    

    (b)          Upon written request by Indemnitee for indemnification pursuant to the first sentence of Section 7(a), a determination, if required by applicable law, with respect to Indemnitee’s entitlement thereto shall
          be made: (i) by Independent Counsel, if requested by Indemnitee with its written request for indemnification; or (ii) if no request is made by the Indemnitee for a determination by Independent Counsel, (A) by the Board (or the Board of Directors
          of the resulting, continuing or surviving entity following a Change of Control), by a majority vote of a quorum consisting of Disinterested Directors, (B) if such a quorum is not obtainable or if such quorum of Disinterested Directors so directs,
          by Independent Counsel in a written opinion to the Board (or the Board of Directors of the resulting, continuing or surviving entity following a Change of Control), a copy of which shall be delivered to the Indemnitee, or (C) if a quorum of
          Disinterested Directors so directs, by the stockholders of the Company.

     

    (c)          In the event the determination of entitlement to indemnification or advancement of Expenses is to be made by Independent Counsel at the request of the Indemnitee, the Independent Counsel shall be selected by the Board,
          unless there shall have occurred, within two (2) years prior to the date of the commencement of the Proceeding with respect to which indemnification or advancement of Expenses is claimed, a Change of Control, in which case the Independent Counsel
          shall be selected by the Indemnitee, unless the Indemnitee shall request that such selection be made by the Board. Indemnitee or the Company, as the case may be, may, within ten (10) days after such written notice of selection shall have been
          given, deliver to the Company or to Indemnitee, as the case may be, a written objection to such selection; provided, however, that such objection may be asserted only on the ground that the Independent Counsel so selected does not meet the
          criteria of “Independent Counsel” as defined in Section 1, and the objection shall set forth with particularity the factual basis of such assertion. Absent a proper and timely objection, the person so selected shall act as Independent Counsel. If
          a written objection is made and substantiated, the Independent Counsel selected may not serve as Independent Counsel unless and until such objection is withdrawn or a court has determined that such objection is without merit. If, within twenty
          (20) days after submission by Indemnitee of a written request for indemnification pursuant to Section 7(a), no Independent Counsel shall have been selected without objection, either the Company or Indemnitee may petition the Court of Chancery of
          the State of Delaware or other court of competent jurisdiction for resolution of any objection which shall have been made by the Company or Indemnitee to the other’s selection of Independent Counsel and/or for the appointment as Independent
          Counsel of a person selected by the court or by such other person as the court shall designate, and the person with respect to whom all objections are so resolved or the person so appointed shall act as Independent Counsel under Section 7(b). The
          Company shall pay any and all reasonable fees and expenses incurred by such Independent Counsel in connection with acting pursuant to Section 7(b), and the Company shall pay all reasonable fees and expenses incident to the procedures of this
          Section 7(c), regardless of the manner in which such Independent Counsel was selected or appointed.

     

    
      

      
        

      

    

    (d)          In making a determination with respect to entitlement to indemnification hereunder, the person or persons or entity making such determination shall presume that Indemnitee is entitled to indemnification under this Agreement.
          Anyone seeking to rebut this presumption shall have the burden of proof.

     

    (e)          Indemnitee shall be deemed to have acted in good faith if his action is based on the records or books of account of the Enterprise, including financial statements, or on information supplied to Indemnitee by the officers or
          other employees of the Enterprise in the course of their duties, or on the advice of legal counsel for the Enterprise or on information or records given or reports made to the Enterprise by an independent certified public accountant or by an
          appraiser or other expert selected with reasonable care by the Enterprise. The parties acknowledge and agree that the foregoing does not represent an exclusive list of the means by which Indemnitee may be deemed to have acted in good faith and in
          a manner he reasonably believed to be in, or not opposed to, the best interests of the Company. In addition, the knowledge or actions, or failure to act, of any director, officer, agent or employee of the Enterprise shall not be imputed to
          Indemnitee for purposes of determining the right to indemnification under this Agreement.

     

    (f)          If
          the person, persons or entity empowered or selected under Section 7 to determine whether Indemnitee is entitled to indemnification shall not have made a determination within thirty (30) days after receipt by the Company of the request therefor,
          the requisite determination of entitlement to indemnification shall be deemed to have been made and Indemnitee shall be entitled to such indemnification absent (i) a misstatement by Indemnitee of a material fact, or an omission of a material fact
          necessary to make Indemnitee’s statement, in light of the context in which it was made, not materially misleading, in connection with the request for indemnification, or (ii) a prohibition of such indemnification under applicable law; provided,
          however, that (A) such 30-day period may be extended for a reasonable time, not to exceed an additional fifteen (15) days, if the person, persons or entity making such determination with respect to entitlement to indemnification in good faith
          requires such additional time to obtain or evaluate documentation or information relating thereto and (B) the foregoing provisions of this Section 7(f) shall not apply if the determination of entitlement to indemnification is to be made by the
          stockholders pursuant to Section 7(b) and (1) within fifteen (15) days after receipt by the Company of the request for such determination, the Board or the Disinterested Directors, if appropriate, resolve to submit such determination to the
          stockholders for their consideration at an annual meeting thereof to be held within seventy-five (75) days after such receipt and such determination is made at such meeting, or (2) a special meeting of stockholders is called within fifteen (15)
          days after such receipt for the purpose of making such determination, such meeting is held for such purpose within sixty (60) days after having been so called and such determination is made at such meeting.

     

    (g)          Indemnitee
          shall cooperate with the person, persons or entity making such determination with respect to Indemnitee’s entitlement to indemnification, including providing to such person, persons or entity upon reasonable advance request any documentation or
          information that is not privileged or otherwise protected from disclosure, available to Indemnitee without undue effort or expense and reasonably necessary to such determination. Any Independent Counsel, member of the Board or stockholder of the
          Company shall act reasonably and in good faith in making a determination regarding the Indemnitee’s entitlement to indemnification under this Agreement. Any costs or expenses (including attorneys’ fees and disbursements) incurred by Indemnitee in
          so cooperating with the person, persons or entity making such determination shall be borne by the Company (irrespective of the determination as to Indemnitee’s entitlement to indemnification) and the Company hereby indemnifies and agrees to hold
          Indemnitee harmless therefrom.

     

    
      

      
        

      

    

    (h)          The Company acknowledges that a settlement or other disposition short of final judgment may be successful if it permits a party to avoid expense, delay, distraction, disruption and uncertainty. In the event that any
          Proceeding to which Indemnitee is a party is resolved in any manner other than by adverse judgment against Indemnitee (including, without limitation, settlement of such Proceeding with or without payment of money or other consideration), it shall
          be presumed that Indemnitee has been successful on the merits or otherwise in such Proceeding. Anyone seeking to rebut this presumption shall have the burden of proof.

     

    8.          Remedies of Indemnitee.

     

    (a)          In the event that (i) a determination is made pursuant to Section 7 that Indemnitee is not entitled to indemnification under this Agreement, (ii) advancement of Expenses is not timely made pursuant to Section 6, (iii) no
          determination of entitlement to indemnification is made pursuant to Section 7(b) within ninety (90) days after receipt by the Company of the written request for indemnification, or (iv) payment of indemnification is not made within ten (10) days
          after a determination has been made that Indemnitee is entitled to indemnification or such determination is deemed to have been made pursuant to Section 7, Indemnitee shall be entitled to an adjudication in an appropriate court of the State of
          Delaware, or in any other court of competent jurisdiction, of his entitlement to such indemnification or advancement of Expenses. Indemnitee shall commence such proceeding seeking an adjudication within one hundred eighty (180) days following the
          date on which Indemnitee first has the right to commence such proceeding pursuant to this Section 8(a). The Company shall not oppose Indemnitee’s right to seek any such adjudication.

     

    (b)          In the event that a determination shall have been made pursuant to Section 7(b) that Indemnitee is not entitled to indemnification, any judicial proceeding commenced pursuant to this Section 8 shall be
          conducted in all respects as a de novo trial on the merits, and Indemnitee shall not be prejudiced by reason of the adverse determination under Section 7(b).

     

    (c)          If a determination shall have been made pursuant to Section 7(b) that Indemnitee is entitled to indemnification, the Company shall be bound by such determination in any judicial proceeding commenced
          pursuant to this Section 8, absent a prohibition of such indemnification under applicable law.

     

    
      

      
        

      

    

    (d)          In the event that Indemnitee, pursuant to this Section 8, seeks a judicial adjudication of his rights under, or to recover damages for breach of, this Agreement, or to recover under any directors’ and
          officers’ liability insurance policies maintained by the Company, the Company shall pay on his behalf, in advance (but subject to the same conditions as are set forth in Section 6 with regard to the advancement of Expenses), any and all expenses
          (of the types described in the definition of Expenses in Section 1) actually and reasonably incurred by him in connection with such judicial adjudication.

     

    (e)          The Company shall be precluded from asserting in any judicial proceeding commenced pursuant to this Section 8 that the procedures and presumptions of this Agreement are not valid, binding and enforceable and shall stipulate
          in any such court that the Company is bound by all the provisions of this Agreement.

     

    9.          Nonexclusivity; Survival of Rights; Insurance; Subrogation.

     

    (a)          The rights of indemnification provided by this Agreement shall not be deemed exclusive of any other rights to which Indemnitee may at any time be entitled under applicable law, the certificate of incorporation of the Company
          (as may be amended or restated from time to time), the Bylaws, any agreement, a vote of stockholders, a resolution of directors or otherwise. No amendment, alteration or repeal of this Agreement or of any provision hereof shall limit or restrict
          any right of Indemnitee under this Agreement in respect of any action taken or omitted by such Indemnitee in his Company Position prior to such amendment, alteration or repeal. To the extent that a change in the DGCL, whether by statute or
          judicial decision, permits greater indemnification than would be afforded currently under this Agreement, it is the intent of the parties that Indemnitee shall enjoy by this Agreement the greater benefits so afforded by such change. No right or
          remedy herein conferred is intended to be exclusive of any other right or remedy, and every other right and remedy shall be cumulative and in addition to every other right and remedy given hereunder or now or hereafter existing at law or in
          equity or otherwise. The assertion or employment of any right or remedy hereunder, or otherwise, shall not prevent the concurrent assertion or employment of any other right or remedy.

     

    (b)          To the extent that the Company maintains an insurance policy or policies providing liability insurance for directors, officers, employees, or agents or fiduciaries of the Company or of any other
          Enterprise, Indemnitee shall be covered by such policy or policies in accordance with its or their terms to the maximum extent of the coverage available for any director, officer, employee, agent or fiduciary under such policy or policies.

     

    (c)          Except as provided in the last sentence of this Section 9(c), in the event of any payment under this Agreement, the Company shall be subrogated to the extent of such payment to all of the rights of recovery of Indemnitee,
          who shall execute all papers and take all action reasonably necessary to secure such rights, including execution of such documents as are reasonably necessary to enable the Company to bring suit to enforce such rights. Notwithstanding the
          foregoing, no right of recovery of Indemnitee pursuant to any (i) director liability insurance policy that covers Indemnitee and is purchased separately by Indemnitee, by any fund or other entity of which Indemnitee is a partner, member or
          stockholder or that employs Indemnitee or by any of their respective affiliates or (ii) indemnification from any fund or other entity of which Indemnitee is a partner, member or stockholder or that employs Indemnitee or from any of its affiliates
          shall be subject to subrogation under this Section 9(c).

     

    
      

      
        

      

    

    (d)          The Company shall not be liable under this Agreement to make any payment of amounts otherwise indemnifiable hereunder if and to the extent that Indemnitee has otherwise actually received such amount under any insurance
          policy, contract, agreement or otherwise.

     

    10.          Mutual Acknowledgment. The Company and Indemnitee acknowledge that, in certain instances, Federal law or applicable public policy (pursuant to the immediately
          following sentence) may prohibit the Company from indemnifying its directors, officers, employees, controlling persons, fiduciaries or other agents or affiliates under this Agreement or otherwise. Indemnitee understands and acknowledges that the
          Company may be required in the future to undertake with the Securities and Exchange Commission to submit the question of indemnification to a court in certain circumstances for a determination of the Company’s rights under public policy to
          indemnify Indemnitee.

     

    11.          Duration of Agreement. All agreements and obligations of the Company contained herein shall continue during the period Indemnitee is a director, officer or member of the executive
          committee of the Company (or is or was serving at the request of the Company as a director, officer, employee or agent of any other Enterprise) and shall continue thereafter if and while Indemnitee shall be subject to any Proceeding (or any
          proceeding commenced under Section 8) by reason of his Company Position, whether or not he is acting or serving in any such capacity at the time of initiation of the Proceeding, while the Proceeding is pending or at the time any liability or
          expense is incurred for which indemnification can be provided under this Agreement. This Agreement shall be binding upon and inure to the benefit of and be enforceable by the parties hereto and their respective successors (including any direct or
          indirect successor by purchase, merger, consolidation or otherwise to all or substantially all of the business or assets of the Company), assigns, spouses, heirs, executors and personal and legal representatives.

     

    12.          Exceptions. Notwithstanding any other provision of this Agreement, the Company shall not be obligated pursuant to the terms of this Agreement:

     

    (a)          Excluded Action or Omissions. To indemnify the Indemnitee in respect of any intentional malfeasance by the Indemnitee or any act undertaken by the
          Indemnitee where the Indemnitee did not in good faith believe the Indemnitee was acting in the best interests of the Company, or for any other acts, omissions or transactions from which the Indemnitee may not be relieved of liability under
          applicable law.

     

    (b)          Claims Initiated by Indemnitee. To indemnify or advance Expenses to Indemnitee with respect to any Proceeding initiated or brought voluntarily by
          Indemnitee and not by way of defense, except (i) with respect to a Proceeding to establish or enforce a right to indemnity under any agreement or insurance policy or under the Company’s certificate of incorporation or Bylaws now or hereafter in
          effect relating to indemnification, (ii) in specific cases if the Board has approved the initiation or bringing of such Proceeding, or (iii) as otherwise required under Section 145 of the DGCL, regardless of whether such Indemnitee ultimately is
          determined to be entitled to such indemnification, advance expense payment or insurance recovery, as the case may be.

     

    
      

      
        

      

    

    (c)          Lack of Good Faith. To indemnify Indemnitee with respect to any

    (i) Proceeding instituted by Indemnitee as contemplated by Section 12(b)(i) or (ii) proceeding instituted by Indemnitee under
      Section 8 to enforce its rights under this Agreement, if a court of competent jurisdiction determines that each of the material assertions made by the Indemnitee in such proceeding was not made in good faith or was frivolous; or

     

    (d)          Claims Under Section 16(b). To indemnify Indemnitee for any Expenses and disgorgement of profits arising from the purchase and sale by Indemnitee of
          securities in violation of Section 16(b) of the Exchange Act or any similar successor statute.

     

    13.          Enforcement.

     

    (a)          The Company expressly (i) confirms and agrees that it has entered into this Agreement and assumes the obligations imposed on it hereby in order to induce Indemnitee to serve as a director, officer or member of the executive
          committee of the Company and

    (ii) acknowledges that Indemnitee is relying upon this Agreement in serving as a director, officer or member of the executive committee of the Company.

     

    (b)          This Agreement constitutes the entire agreement between the parties hereto with respect to the subject matter hereof and supersedes all prior agreements and understandings, oral, written and implied, between the parties
          hereto with respect to the subject matter hereof.

     

    14.          Severability. If any provision or provisions of this Agreement shall be held by a

    court of competent jurisdiction to be invalid, void, illegal or otherwise unenforceable for any reason whatsoever: (i) the validity, legality and
      enforceability of the remaining provisions of this Agreement (including without limitation, each portion of any section of this Agreement containing any such provision held to be invalid, illegal or unenforceable that is not itself invalid, illegal
      or unenforceable) shall not in any way be affected or impaired thereby and shall remain enforceable to the fullest extent permitted by law; and (ii) to the fullest extent possible, the provisions of this Agreement (including, without limitation, each
      portion of any section of this Agreement containing any such provision held to be invalid, illegal or unenforceable that is not itself invalid, illegal or unenforceable) shall be construed so as to give effect to the intent manifested thereby.
      Without limiting the generality of the foregoing, this Agreement is intended to confer upon Indemnitee indemnification rights to the fullest extent permitted by applicable law. In the event any provision hereof conflicts with any applicable law, such
      provision shall be deemed modified, consistent with the aforementioned intent, to the extent necessary to resolve such conflict.

     

    15.          Modification and Waiver. No supplement, modification, termination or

    amendment of this Agreement shall be binding unless executed in writing by both parties. No waiver of any of the provisions of this Agreement shall be
      deemed or shall constitute a waiver of any other provisions hereof (whether or not similar) nor shall such waiver constitute a continuing waiver.

     

    
      

      
        

      

    

    16.          Notice By Indemnitee. Indemnitee agrees promptly to notify the Company in

    writing upon being served with or otherwise receiving any summons, citation, subpoena, complaint, indictment, information or other
      document relating to any Proceeding or matter that may be subject to indemnification hereunder. The failure to so notify the Company shall not relieve the Company of any obligation which it may have to Indemnitee under this Agreement or otherwise
      unless and only to the extent that such failure or delay materially prejudices the Company.

     

    17.          Notices. All notices, requests, demands and other communications hereunder

     

    shall be in writing and shall be deemed to have been duly given if (i) delivered by hand and received by the party to whom said
      notice or other communication shall have been directed, or (ii) mailed by certified or registered mail with postage prepaid, on the third business day after the date on which it is so mailed:

     

    (a)          If to Indemnitee, to the address set forth below Indemnitee’s signature hereto.

     

    (b)          If to the Company, to:

     

    Catalyst Biosciences, Inc.

    611 Gateway Boulevard, Suite 120

      South San Francisco, CA 94080

      Attention: Interim Chief Financial Officer

     

    or to such other address as may have been furnished to Indemnitee by the Company or to the Company by Indemnitee, as the case may
      be.

     

    18.          Counterparts. This Agreement may be executed in two counterparts, each of

     

    which shall for all purposes be deemed to be an original and both of which together shall constitute one and the same agreement.
      Only one such counterpart signed by the party against whom enforceability is sought needs to be produced to evidence the existence of this Agreement.

     

    19.          Headings. The headings of the paragraphs of this Agreement are inserted for

     

    convenience only and shall not be deemed to constitute part of this Agreement or to affect the construction thereof.

     

    20.          Governing Law. The parties agree that this Agreement shall be governed by, and
      construed and enforced in accordance with, the laws of the State of Delaware without application of the principles of conflicts of laws thereof.

     

    21.          Gender. Use of the masculine pronoun herein shall be deemed to include also the corresponding feminine pronoun.

     

    
      

      
        

      

    

    
      
        IN WITNESS WHEREOF, the parties hereto have executed this Agreement on and as of the day and year
          first above written.

      

       

      	 	
              COMPANY:

            
	 	 
	 	
              CATALYST BIOSCIENCES, INC.

            
	 	  
	 	
              

              

            
	 	 

            
	 	 
	 	
              Signature of Authorized Signatory

              

            
	 	 
	 	
              Print Name

              

            
	 	
              

              

            
	 	 
	 	
              Title

              

            
	 	 
	
              INDEMNITEE: 

              

            	 
	 	 
	

            	 	 
	 	 
	Signature

            	 
	 	 
	 	 
	 	 	 	 
	Print Name and Title

            	 
	 	 
	 	 
	Address:	

            	 	 	 
	 	 

      

      

      

      

    

  

  
    [Signature Page to Indemnification Agreement]EX-10.1

 Exhibit 10.1 

JOINDER AND FIRST LOAN MODIFICATION AGREEMENT 

This Joinder and First Loan Modification Agreement (this “Loan Modification Agreement”) is entered into as of
December 23, 2022, by and among (a) SILICON VALLEY BANK, a California corporation, with a loan production office located at 275 Grove Street, Suite 2-200, Newton, Massachusetts 02466
(“SVB”), in its capacity as administrative agent and collateral agent (“Agent”), (b) SILICON VALLEY BANK, a California corporation, as a lender, (c) SVB INNOVATION CREDIT FUND VIII, L.P., a
Delaware limited partnership (“SVB Innovation”), as a lender (SVB and SVB Innovation and each of the other “Lenders” from time to time a party to the Loan Agreement (as hereinafter defined) are referred to herein
collectively as the “Lenders” and each individually as a “Lender”), (d) AKILI INTERACTIVE LABS, INC., a Delaware corporation with its principal place of business located at 125 Broad Street, 4th Floor,
Boston, Massachusetts 02110 (“Existing Borrower”), and (e) AKILI, INC., a Delaware corporation (“New Borrower”) (New Borrower and Existing Borrower, are hereinafter jointly and severally,
individually and collectively, “Borrower”). 
 1.    DESCRIPTION OF EXISTING INDEBTEDNESS AND OBLIGATIONS.
Borrower entered into a certain Amended and Restated Loan and Security Agreement dated as of May 25, 2021, among Borrower, the Lenders and Agent (as may be amended, modified, restated, replaced or supplemented from time to time, the
“Loan Agreement”). Capitalized terms used but not otherwise defined herein shall have the same meaning as in the Loan Agreement. 

2.    JOINDER TO LOAN AGREEMENT. New Borrower hereby joins the Loan Agreement and each of the other appropriate Loan Documents, and
agrees to comply with and be bound by all of the terms, conditions and covenants of the Loan Agreement and other appropriate Loan Documents, as if it were originally named a “Borrower” therein. Without limiting the generality of the
preceding sentence, New Borrower agrees that it will be jointly and severally liable, together with the Existing Borrower, for the payment and performance of all obligations and liabilities of Borrower when due under the Loan Agreement, including,
without limitation, the Obligations. Each Borrower hereby appoints the other as agent for the other for all purposes hereunder. Each Borrower hereunder shall be obligated to repay all Credit Extensions made pursuant to the Loan Agreement, regardless
of which Borrower actually receives said Credit Extension, as if each Borrower hereunder directly received all Credit Extensions. 

3.    SUBROGATION AND SIMILAR RIGHTS. Each Borrower waives any suretyship defenses available to it under the Code or any other
applicable law. Each Borrower waives any right to require Agent or the Lenders to: (i) proceed against any other Borrower or any other person; (ii) proceed against or exhaust any security; or (iii) pursue any other remedy. Agent and
the Lenders may exercise or not exercise any right or remedy it has against any Borrower or any security it holds (including the right to foreclose by judicial or non-judicial sale) without affecting any
Borrower’s liability. Notwithstanding any other provision of this Loan Modification Agreement, the Loan Agreement or other Loan Documents, each Borrower irrevocably waives all rights that it may have at law or in equity (including, without
limitation, any law subrogating Borrower to the rights of Agent or the Lenders under the Loan Agreement) to seek contribution, indemnification or any other form of reimbursement from any other Borrower, or any other Person now or hereafter primarily
or secondarily liable for any of the Obligations, for any payment made by Borrower with respect to the Obligations in connection with the Loan Agreement or otherwise and all rights that it might have to benefit from, or to participate in, any
security for the Obligations as a result of any payment made by Borrower with respect to the Obligations in connection with the Loan Agreement or otherwise, until the payment in full of the Obligations (other than inchoate indemnity or other
obligations which, by their terms, survive termination of the Loan Agreement and the termination of the Loan Documents). Any agreement providing for indemnification, reimbursement or any other arrangement prohibited under this Section 3 shall
be null and void. If any payment is made to a Borrower in contravention of this Section 3, such Borrower shall hold such payment in trust for Agent and such payment shall be promptly delivered to Agent for application to the Obligations,
whether matured or unmatured. 

  
 1 

 4.    GRANT OF SECURITY INTEREST. To secure the payment and performance of all of
the Obligations, New Borrower hereby grants to Agent, for the ratable benefit of the Lenders a continuing lien upon and security interest in all of New Borrower’s now existing or hereafter arising rights and interests in such assets of New
Borrower as are consistent with the description of the Collateral set forth on Exhibit A of the Loan Agreement (as if such Collateral were deemed to pertain to the assets of New Borrower), whether now owned or existing or hereafter created,
acquired, or arising, and wherever located, including, without limitation, all of New Borrower’s personal property (consistent with the description of Collateral as set forth on Exhibit A of the Loan Agreement), and all New
Borrower’s books relating to the foregoing and any and all claims, rights and interests in any of the above and all substitutions for, additions, attachments, accessories, accessions and improvements to and replacements, products, proceeds and
insurance proceeds of any or all of the foregoing. New Borrower further covenants and agrees that by its execution hereof it shall provide all such information, complete all such forms, and take all such actions, and enter into all such agreements,
in form and substance reasonably satisfactory to Agent and the Lenders that are reasonably deemed necessary by Agent and the Lenders in order to grant a valid, perfected first priority security interest to Agent, for the ratable benefit of the
Lenders, in the Collateral (subject only to Permitted Liens that are permitted pursuant to the terms of the Loan Agreement to have superior priority to Agent’s Lien in the Loan Agreement). New Borrower hereby authorizes Agent to file financing
statements, without notice to Borrower, with all appropriate jurisdictions in order to perfect or protect Agent’s interest or rights hereunder, including a notice that any disposition of the Collateral in contravention of the Loan Agreement, by
either Borrower or any other Person shall be deemed to violate the rights of Agent under the Code. Such financing statements may indicate the Collateral as “all assets of the Debtor” or words of similar effect, or as being of an equal or
lesser scope, or with greater detail, all in Agent’s discretion. 
 5.    REPRESENTATIONS AND WARRANTIES. New Borrower
hereby represents and warrants to Agent and the Lenders that all representations and warranties in the Loan Documents made on the part of Existing Borrower are true and correct on the date hereof with respect to New Borrower, with the same force and
effect as if New Borrower was named as “Borrower” in the Loan Documents in addition to Existing Borrower (except to the extent such representations and warranties relate to a specific date which shall be true and correct in all material
respects as of such date). 
 6.    DESCRIPTION OF COLLATERAL. Repayment of the Obligations is secured by the Collateral as
defined in the Loan Agreement (together with any other collateral security granted to Agent by Borrower pursuant to the Loan Documents, for the ratable benefit of the Lenders, as amended, the “Security Documents”). Hereinafter, the
Security Documents, together with all other documents evidencing or securing the Obligations shall be referred to as the “Existing Loan Documents”. 

7.    DELIVERY OF DOCUMENTS. Each Borrower hereby agrees that the following documents shall be delivered to Agent prior to or
contemporaneously with delivery of this Loan Modification Agreement, each in form and substance satisfactory to Agent and the Lenders: 
  

	 	A.	 a secretary’s corporate borrowing certificate for New Borrower with respect to New Borrower’s
certificate of incorporation, by-laws, incumbency and resolutions authorizing the execution and delivery of this Loan Modification Agreement and the other documents required by Agent and the Lenders in
connection with this Loan Modification Agreement; 

  

	 	B.	 a long form Certificate of Good Standing for New Borrower certified by the Secretary of State of Delaware;

  

	 	C.	 certificates of Good Standing/Foreign Qualification, as applicable, certified by the Secretary of State (or
equivalent agency) for each state in which New Borrower is qualified to do business; 

  

	 	D.	 the results of UCC searches for New Borrower indicating that there are no Liens other than Permitted Liens, and
otherwise in form and substance satisfactory to Agent and the Lenders; 

  

	 	E.	 a Perfection Certificate for New Borrower; 

 

	 	F.	 evidence of insurance (on Acord 28 and Acord 25 certificates, together with endorsements to the liability and
property policies, as acceptable to Agent and the Lenders; 

  
 2 

	 	G.	 a First Amendment to and Ratification of Subordination Agreement with Shionogi & Co., Ltd., together
with the duly executed signatures thereto; 

  

	 	H.	 a legal opinion (authority and enforceability) of New Borrower’s counsel dated as of the Effective Date,
together with the duly executed signature thereto; and 

  

	 	I.	 such other documents as Agent and the Lenders may have reasonably requested. 

8.    DESCRIPTION OF CHANGE IN TERMS. 
  

	 	A.	 Modifications to Loan Agreement. 

 

	 	1	 The Loan Agreement shall be amended by deleting the following text, appearing in Section 2.2(a) thereof:

 “Subject to the terms and conditions of this Agreement, upon Borrower’s request, during the Term A Loan Draw
Period, the Lenders, severally and not jointly, shall make term loan advances available to Borrower in an original principal amount of up to Thirty-Five Million Dollars ($35,000,000.00) according to each Lender’s Term A Loan Commitment as set
forth on Schedule 1 hereto (each, a “Term A Loan Advance” and, collectively, the “Term A Loan Advances”);” 

and inserting in lieu thereof the following:     

“Subject to the terms and conditions of this Agreement, upon Borrower’s request, during the Term A Loan Draw Period, the Lenders,
severally and not jointly, shall make term loan advances available to Borrower in an original principal amount of up to Twenty-Five Million Dollars ($25,000,000.00) according to each Lender’s Term A Loan Commitment as set forth on Schedule 1
hereto (each, a “Term A Loan Advance” and, collectively, the “Term A Loan Advances”);” 
  

	 	2	 The Loan Agreement shall be amended by deleting the following text, appearing in Section 2.2(a) thereof:

 “Subject to the terms and conditions of this Agreement, upon Borrower’s request, during the Term C Loan Draw
Period, the Lenders, severally and not jointly, shall make term loan advances available to Borrower in an original principal amount of up to Ten Million Dollars ($10,000,000.00) according to each Lender’s Term C Loan Commitment as set forth on
Schedule 1 hereto (each, a “Term C Loan Advance” and, collectively, the “Term C Loan Advances”).” 

and inserting in lieu thereof the following:     

“Subject to the terms and conditions of this Agreement, upon Borrower’s request, during the Term C Loan Draw Period, the Lenders,
severally and not jointly, shall make term loan advances available to Borrower in an original principal amount of up to Twenty Million Dollars ($20,000,000.00) according to each Lender’s Term C Loan Commitment as set forth on Schedule 1 hereto
(each, a “Term C Loan Advance” and, collectively, the “Term C Loan Advances”).” 

  
 3 

	 	3	 The Loan Agreement shall be amended by inserting the following new Section 9.9, to appear immediately
following Section 9.8 thereof: 

 “    9.9 Borrower Liability. Any Borrower may,
acting singly, request Credit Extensions hereunder. Each Borrower hereby appoints each other as agent for the other for all purposes hereunder, including with respect to requesting Credit Extensions hereunder. Each Borrower hereunder shall be
jointly and severally obligated to repay all Credit Extensions made hereunder, regardless of which Borrower actually receives said Credit Extension, as if each Borrower hereunder directly received all Credit Extensions. Each Borrower waives
(a) any suretyship defenses available to it under the Code or any other applicable law, and (b) any right to require Agent or the Lenders to: (i) proceed against any Borrower or any other person; (ii) proceed against or exhaust
any security; or (iii) pursue any other remedy. Agent and the Lenders may exercise or not exercise any right or remedy it has against any Borrower or any security it holds (including the right to foreclose by judicial or non-judicial sale) without affecting any Borrower’s liability. Notwithstanding any other provision of this Agreement or other related document, each Borrower irrevocably waives all rights that it may have at
law or in equity (including, without limitation, any law subrogating Borrower to the rights of Agent or the Lenders under this Agreement) to seek contribution, indemnification or any other form of reimbursement from any other Borrower, or any other
Person now or hereafter primarily or secondarily liable for any of the Obligations, for any payment made by Borrower with respect to the Obligations in connection with this Agreement or otherwise and all rights that it might have to benefit from, or
to participate in, any security for the Obligations as a result of any payment made by Borrower with respect to the Obligations in connection with this Agreement or otherwise, until the payment in full of the Obligations (other than inchoate
indemnity or other obligations which, by their terms, survive termination of the Loan Agreement and the termination of the Loan Documents). Any agreement providing for indemnification, reimbursement or any other arrangement prohibited under this
Section 9.9 shall be null and void. If any payment is made to a Borrower in contravention of this Section 9.9, such Borrower shall hold such payment in trust for Agent and such payment shall be promptly delivered to Agent for application
to the Obligations, whether matured or unmatured.” 
  

	 	4	 The Loan Agreement shall be amended by inserting the following new definitions, appearing alphabetically in
Section 14.1 thereof: 

 “    “Akili” is Akili, Inc., a Delaware
corporation.” 
 “    “Interactive” is Akili Interactive Labs, Inc., a Delaware
corporation.” 
  

	 	5	 The Loan Agreement shall be amended by deleting the following definitions, appearing in Section 14.1
thereof: 

 “    “Borrower” is defined in the preamble hereof.” 

“    “Term A Loan Draw Period” is the period of time commencing upon the Effective Date and
continuing through the earlier to occur of (a) June 30, 2022; provided, however, that such date shall be September 30, 2022 if the aggregate original principal amount of Term A Loan Advances made by the Lenders on or prior to
June 30, 2022 is equal to at least Fifteen Million Dollars ($15,000,000.00) or (b) an Event of Default.” 

“    “Term C Loan Draw Period” is the period of time commencing upon the occurrence of the Third
Tranche Availability Event and continuing through the earlier to occur of (a) December 31, 2022 or (b) an Event of Default.” 

  
 4 

 and inserting in lieu thereof the following: 

“    “Borrower” means, individually and collectively, jointly and severally, Interactive and
Akili.” 
 “    “Term A Loan Draw Period” is the period of time commencing upon the Effective
Date and continuing through the earlier to occur of (a) March 31, 2023 or (b) an Event of Default.” 

“    “Term C Loan Draw Period” is the period of time commencing upon the occurrence of the Third
Tranche Availability Event and continuing through the earlier to occur of (a) May 31, 2023 or (b) an Event of Default.” 
  

	 	6	 Schedule 1 to the Loan Agreement is hereby deleted in its entirety and replaced with Schedule 1
hereto. 

  

	 	7	 The Compliance Statement appearing as Exhibit B to the Loan Agreement is hereby replaced with the
Compliance Statement attached as Schedule 2 hereto. 

  

	 	8	 The Payment/Advance Form appearing as Exhibit C to the Loan Agreement is hereby deleted and replaced
with the Payment/Advance Form attached as Schedule 3 hereto.  

 9.    FEES AND EXPENSES.
Borrower shall reimburse Agent for all of Agent’s and the Lenders’ reasonable and documented legal fees and expenses incurred in connection with this amendment to the Existing Loan Documents, provided that legal fees (exclusive of
expenses) incurred for the documentation of this Loan Modification Agreement, as of the date hereof, shall not exceed Fifteen Thousand Dollars ($15,000.00). 

10.    RATIFICATION OF PERFECTION CERTIFICATE. 

(a)    Existing Borrower hereby ratifies, confirms and reaffirms, all and singular, the terms and disclosures contained in
a certain Perfection Certificate of Existing Borrower dated as of December 22, 2022 (the “Existing Borrower Perfection Certificate”) delivered by Existing Borrower to the Lenders and acknowledges, confirms and agrees that the
disclosures and information Existing Borrower provided to the Lenders in such Perfection Certificate have not changed, as of the date hereof. 

(b)    In connection with this Loan Modification Agreement, New Borrower has delivered to the Lenders a Perfection
Certificate signed by New Borrower dated as of the date of this Loan Modification Agreement (the “New Borrower Perfection Certificate”). New Borrower represents and warrants to the Lenders that: (i) New Borrower’s exact
legal name is that indicated on the New Borrower Perfection Certificate and on the signature page hereof; (ii) New Borrower is an organization of the type, and is organized in the jurisdiction, set forth in the New Borrower Perfection
Certificate; and (iii) the New Borrower Perfection Certificate accurately sets forth New Borrower’s organizational identification number or accurately states that New Borrower has none; (iv) the New Borrower Perfection Certificate
accurately sets forth New Borrower’s place of business, or, if more than one, its chief executive office as well as New Borrower’s mailing address if different, and (v) all other information set forth on the New Borrower Perfection
Certificate pertaining to New Borrower is accurate and complete as of the date hereof. 
 Borrower hereby acknowledges and agree that all
references to the Loan Agreement to the “Perfection Certificate” shall mean and included, collectively, the Existing Borrower Perfection Certificate and the New Borrower Perfection Certificate 

11.    CONSISTENT CHANGES. The Existing Loan Documents are hereby amended wherever necessary to reflect the changes described
above. 
 12.    RATIFICATION OF LOAN DOCUMENTS. Borrower hereby ratifies, confirms, and reaffirms all terms and conditions of
all security or other collateral granted to Agent, for the ratable benefit of the Lenders, and confirms that the indebtedness secured thereby includes, without limitation, the Obligations. 

  
 5 

 13.    RELEASE BY BORROWER. 

 

	 	A.	 FOR GOOD AND VALUABLE CONSIDERATION, Borrower hereby forever relieves, releases, and discharges Agent, the
Lenders and their present or former employees, officers, directors, agents, representatives, attorneys, and each of them, from any and all claims, debts, liabilities, demands, obligations, promises, acts, agreements, costs and expenses, actions and
causes of action, of every type, kind, nature, description or character whatsoever, whether known or unknown, suspected or unsuspected, absolute or contingent, arising out of or in any manner whatsoever connected with or related to facts,
circumstances, issues, controversies or claims existing or arising from the beginning of time through and including the date of execution of this Loan Modification Agreement (collectively “Released Claims”). Without limiting
the foregoing, the Released Claims shall include any and all liabilities or claims arising out of or in any manner whatsoever connected with or related to the Loan Documents, the recitals hereto, any instruments, agreements or documents executed in
connection with any of the foregoing or the origination, negotiation, administration, servicing and/or enforcement of any of the foregoing. 

  

	 	B.	 In furtherance of this release, Borrower expressly acknowledges and waives any and all rights under
Section 1542 of the California Civil Code, which provides as follows: 

 “A general release does not
extend to claims that the creditor or releasing party does not know or suspect to exist in his or her favor at the time of executing the release and that, if known by him or her, would have materially affected his or her settlement with the debtor
or released party.” (Emphasis added.) 
  

	 	C.	 By entering into this release, Borrower recognizes that no facts or representations are ever absolutely certain
and it may hereafter discover facts in addition to or different from those which it presently knows or believes to be true, but that it is the intention of Borrower hereby to fully, finally and forever settle and release all matters, disputes and
differences, known or unknown, suspected or unsuspected; accordingly, if Borrower should subsequently discover that any fact that it relied upon in entering into this release was untrue, or that any understanding of the facts was incorrect, Borrower
shall not be entitled to set aside this release by reason thereof, regardless of any claim of mistake of fact or law or any other circumstances whatsoever. Borrower acknowledges that it is not relying upon and has not relied upon any representation
or statement made by Agent or any Lender with respect to the facts underlying this release or with regard to any of such party’s rights or asserted rights. 

 

	 	D.	 This release may be pleaded as a full and complete defense and/or as a cross-complaint or counterclaim against
any action, suit, or other proceeding that may be instituted, prosecuted or attempted in breach of this release. Borrower acknowledges that the release contained herein constitutes a material inducement to Agent and the Lenders to enter into this
Loan Modification Agreement, and that Agent and the Lenders would not have done so but for Agent’s and the Lenders’ expectation that such release is valid and enforceable in all events. 

 

	 	E.	 Borrower hereby represents and warrants to Agent and the Lenders, and Agent and the Lenders are relying
thereon, as follows: 

  

	 	1	 Except as expressly stated in this Loan Modification Agreement, none of Agent, the Lenders nor any agent,
employee or representative of Agent or the Lenders has made any statement or representation to Borrower regarding any fact relied upon by Borrower in entering into this Loan Modification Agreement. 

 

	 	2	 Borrower has made such investigation of the facts pertaining to this Loan Modification Agreement and all of the
matters appertaining thereto, as it deems necessary. 

  
 6 

	 	3	 The terms of this Loan Modification Agreement are contractual and not a mere recital. 

 

	 	4	 This Loan Modification Agreement has been carefully read by Borrower, the contents hereof are known and
understood by Borrower, and this Loan Modification Agreement is signed freely, and without duress, by Borrower. 

  

	 	5	 Borrower represents and warrants that it is the sole and lawful owner of all right, title and interest in and
to every claim and every other matter which it releases herein, and that it has not heretofore assigned or transferred, or purported to assign or transfer, to any person, firm or entity any claims or other matters herein released. Borrower shall
indemnify Agent and the Lenders, defend and hold it harmless from and against all claims based upon or arising in connection with prior assignments or purported assignments or transfers of any claims or matters released herein.

 14.    CONTINUING VALIDITY. Borrower understands and agrees that in modifying the existing Obligations,
Agent and the Lenders are relying upon Borrower’s representations, warranties, and agreements, as set forth in the Existing Loan Documents. Except as expressly modified pursuant to this Loan Modification Agreement, the terms of the Existing
Loan Documents remain unchanged and in full force and effect. Agent’s and the Lenders’ agreement to modifications to the existing Obligations pursuant to this Loan Modification Agreement in no way shall obligate Agent or the Lenders to
make any future modifications to the Obligations. Nothing in this Loan Modification Agreement shall constitute a satisfaction of the Obligations. It is the intention of Agent, the Lenders and Borrower to retain as liable parties all makers of
Existing Loan Documents, unless the party is expressly released by Agent and the Lenders in writing. No maker will be released by virtue of this Loan Modification Agreement. 

15.    COUNTERSIGNATURE. This Loan Modification Agreement shall become effective only when it shall have been executed by Borrower,
Agent, and the Lenders. 
 16.    COUNTERPARTS. This Loan Modification Agreement may be executed in any number of
counterparts (including by PDF or other electronic transmission, or facsimile) and all of such counterparts taken together shall be deemed to constitute one and the same instrument. 

[The remainder of this page is intentionally left blank] 

  
 7 

 IN WITNESS WHEREOF, the parties hereto have caused this Loan Modification Agreement to be
executed as a sealed instrument under the laws of the Commonwealth of Massachusetts as of the date first written above. 
  

			
	EXISTING BORROWER:
	
	AKILI INTERACTIVE LABS, INC.
		
	By	 	 /s/ Santosh Shanbhag

	Name:	 	Santosh Shanbhag
	Title:	 	Treasurer
	
	NEW BORROWER:
	
	AKILI, INC.
		
	By	 	 /s/ Santosh Shanbhag

	Name:	 	Santosh Shanbhag
	Title:	 	Chief Financial Officer
	
	AGENT:
	
	SILICON VALLEY BANK, as Agent
		
	By	 	 /s/ Sam Subilia

	Name:	 	Sam Subilia
	Title:	 	Managing Director
	
	LENDERS:
	
	SILICON VALLEY BANK
		
	By	 	 /s/ Sam Subilia

	Name:	 	Sam Subilia
	Title:	 	Managing Director

			
	SVB INNOVATION CREDIT FUND VIII, L.P., as Lender
	By: SVB Innovation Credit Partners VIII, LLC, a Delaware limited liability company, its General Partner
		
	By	 	 /s/ J.P. Michael

	Name:	 	J.P. Michael
	Title:	 	Senior Managing Director

 SCHEDULE 1 

LENDERS AND COMMITMENTS 

TERM A LOAN COMMITMENT 
  

									
	 Lender
	  	Term A Loan Commitment	 	  	Term A Loan
Commitment Percentage	 
	 Silicon Valley Bank
	  	$	12,500,000.00	 	  	 	50.0	% 
	 SVB Innovation Credit Fund VIII, L.P.
	  	$	12,500,000.00	 	  	 	50.0	% 
		  	  
	  
	 	  	  
	  
	 
	 TOTAL
	  	$	25,000,000.00	 	  	 	100.0	% 
		  	  
	  
	 	  	  
	  
	 

 TERM B LOAN COMMITMENT 
  

									
	 Lender
	  	Term B Loan Commitment	 	  	Term B Loan Commitment
Percentage	 
	 Silicon Valley Bank
	  	$	2,500,000.00	 	  	 	50.0	% 
	 SVB Innovation Credit Fund VIII, L.P.
	  	$	2,500,000.00	 	  	 	50.0	% 
		  	  
	  
	 	  	  
	  
	 
	 TOTAL
	  	$	5,000,000.00	 	  	 	100.0	% 
		  	  
	  
	 	  	  
	  
	 

 TERM C LOAN COMMITMENT 
  

									
	 Lender
	  	Term C Loan Commitment	 	  	Term C Loan
Commitment Percentage	 
	 Silicon Valley Bank
	  	$	10,000,000.00	 	  	 	50.0	% 
	 SVB Innovation Credit Fund VIII, L.P.
	  	$	10,000,000.00	 	  	 	50.0	% 
		  	  
	  
	 	  	  
	  
	 
	 TOTAL
	  	$	20,000,000.00	 	  	 	100.0	% 
		  	  
	  
	 	  	  
	  
	 

 SCHEDULE 2 

EXHIBIT B 

COMPLIANCE STATEMENT 

TO:        SILICON VALLEY BANK, as Agent, SVB, and SVB Innovation Fund Date: 

FROM:  AKILI INTERACTIVE LABS, INC. 

     AKILI, INC. 

Under the terms and conditions of the Amended and Restated Loan and Security Agreement by and among Borrower, Agent and the Lenders (the
“Agreement”), Borrower is in complete compliance for the period ending                      with all required covenants
except as noted below. Attached are the required documents supporting the certification. Attached are the required documents evidencing such compliance, setting forth calculations prepared in accordance with GAAP consistently applied from one period
to the next except as explained in an accompanying letter or footnotes. Capitalized terms used but not otherwise defined herein shall have the meanings given them in the Agreement. 

Please indicate compliance status by circling Yes/No under “Complies” column. 

 

					
			
	 Reporting Covenants
	 	 Required
	  	 Complies

	Monthly financial statements with Compliance Statement	 	Monthly within 30 days	  	Yes  No
			
	Annual financial statement (CPA Audited)	 	FYE within 180 days	  	Yes  No
			
	Filed 10-Q, 10-K and 8-K	 	Within 5 days after filing with SEC	  	Yes  No
			
	Board-Approved Projections	 	Within 60 days of Borrower’s FYE, and as amended/updated	  	Yes  No

  

											
	 Financial Covenant
	  	Required	 	  	Actual	 	  	 Complies

	 Maintain as indicated:
	  				  				  	
	 Minimum EndeavorRX Revenue (trailing three month)(tested quarterly)
	  	>$	             	* 	  	$	             	 	  	Yes No N/A

  

	*	 As set forth in Section 6.7. Not tested for any Tested Quarter (a) with respect to which Borrower
maintained the Minimum Cash Balance ($60,000,000) at all times during the period commencing on the first day of such Tested Quarter through and including the date that is 30 days after the last day of such Tested Quarter, or (b) ending prior to
the Funding Date of the first Term B Loan Advance. 

 Other Matters 

 

					
	Have there been any amendments of or other changes to the capitalization table of Borrower and to the Operating Documents of Borrower or any of its Subsidiaries? If yes, provide copies of any such amendments or changes with this
Compliance Statement.	  	Yes	  	No
			
	Has Borrower maintained unrestricted cash at SVB equal to the lesser of (i) 100.0% of the Dollar value of all of Borrower’s consolidated cash, including any Subsidiaries’, Affiliates’, or related entities’ cash,
in the aggregate at all financial institutions, and (ii) 105.0% of the then-outstanding Obligations of Borrower to Agent and the Lenders, at all times during the month ending on the date set forth above?	  	Yes	  	No

 The following financial covenant analyses and information set forth in Schedule 1 attached hereto are true
and accurate as of the date of this Compliance Statement. 
 The following are the exceptions with respect to the statements above: (If no exceptions exist,
state “No exceptions to note.”) 
  
  

 
  
  

 

 Schedule 1 to Compliance Certificate 

Financial Covenants of Borrower 

In the event of a conflict between this Schedule and the Agreement, the terms of the Agreement shall govern. 

Dated:                      

 

	I.	 Minimum EndeavorRX Revenue (Section 6.7) (tested quarterly for the trailing three month period ending on
the last day of each quarter ending on and after the Funding Date of the first Term B Loan Advance) 

 Required:
                     (see chart below) 
  

					
	 Quarter Ending
	  	EndeavorRX
Revenue	 
	 June 30, 2021
	  	$	268,450.00	 
	 September 30, 2021
	  	$	898,275.00	 
	 December 31, 2021
	  	$	2,106,300.00	 
	 March 31, 2022
	  	$	4,206,285.00	 
	 June 30, 2022
	  	$	6,231,108.00	 
	 September 30, 2022
	  	$	8,312,740.00	 
	 December 31, 2022
	  	$	10,820,696.00	 
	 March 31, 2023
	  	$	13,669,909.00	 
	 June 30, 2023
	  	$	17,355,925.00	 
	 September 30, 2023
	  	$	21,411,268.00	 
	 December 31, 2023*
	  	$	25,873,779.00	 

  

	*	 See Section 6.7 for periods ending after December 31, 2023. 

Actual: 
  

							
	 A.
	 	Revenue (calculated in accordance with GAAP) from Borrower’s EndeavorRx product	  	$	             	 

 Is line A equal to or greater than the amount set forth above? 

            No, not in
compliance             Yes, in compliance            N/A* 

 

	*	 Not tested for any Tested Quarter (a) with respect to which Borrower maintained the Minimum Cash Balance
($60,000,000) at all times during the period commencing on the first day of such Tested Quarter through and including the date that is 30 days after the last day of such Tested Quarter, or (b) ending prior to the Funding Date of the first Term
B Loan Advance. 

 SCHEDULE 3 

LOAN PAYMENT/ADVANCE REQUEST FORM 

DEADLINE FOR SAME DAY PROCESSING IS 1:00 p.m.
EASTERN TIME 
  

	 Fax To: 
	Date:                      

 

LOAN PAYMENT:   AKILI INTERACTIVE LABS, INC. 

AKILI, INC. 

	
From Account #                      
                                         
                  
	To Account
#                                         
                                       

	           (Deposit Account #) 
	            (Loan Account #) 

	
Principal $                       
                                         
                         
	and/or Interest
$                                         
                                    

 

	
Authorized Signature:                     
                        
	Phone
Number:                                        
 

 Print Name/Title:
                                         
          

 

LOAN ADVANCE: 

Complete Outgoing Wire Request section below if all or a portion of the funds from this loan advance are for an outgoing wire. 

 

	
From Account #                
                                         
                        
	To Account
#                                         
                                       

	           (Loan Account #) 
	            (Deposit Account #) 

 Amount of Term Loan Advance
$                                         
                
 All Borrower’s representations and warranties in the
Amended and Restated Loan and Security Agreement are true, correct and complete in all material respects on the date of the request for an advance; provided, however, that such materiality qualifier shall not be applicable to any representations and
warranties that already are qualified or modified by materiality in the text thereof; and provided, further that those representations and warranties expressly referring to a specific date shall be true, accurate and complete in all material
respects as of such date. 
  

	
Authorized Signature:                
                             
	Phone
Number:                                        
                     

Print Name/Title:
                                         
            

 

OUTGOING WIRE REQUEST: 

Complete only if all or a portion of funds from the loan advance above is to be wired. 

Deadline for same day processing is 1:00 pm, Eastern Time 
  

	
Beneficiary Name:                 
                                         
    
	Amount of Wire:
$                                         
                    

	
Beneficiary Bank:                 
                                         
     
	Account
Number:                                        
                     

 City and State:
                                         
                              

 

	
Beneficiary Bank Transit (ABA) #:           
                       
	Beneficiary Bank Code (Swift, Sort, Chip, etc.):                  

(For International Wire Only) 

	
Intermediary Bank:                
                                         
     
	Transit (ABA)
#:                                        
                     

 For Further
Credit to:
                                         
                                         
                                         
                                         
               
 Special Instruction:
                                         
                                         
                                         
                                         
                    
 By signing below, I (we) acknowledge
and agree that my (our) funds transfer request shall be processed in accordance with and subject to the terms and conditions set forth in the agreements(s) covering funds transfer service(s), which agreements(s) were previously received and executed
by me (us). 
  

	 Authorized Signature:
                                         
                    
	2nd Signature (if required):
                                         
                     

	 Print
Name/Title:                                       
                      
	Print Name/Title:
                                         
                    

	 Telephone #:
                                         
                        
	Telephone
#:                                        
                     

NY:2453030

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