Document:

Exhibit 10.26
Certain information marked as [***] has been excluded from this exhibit because it is both (i) not material and (ii) is the type that the Company treats as private or confidential.
FIRST AMENDMENT TO
COLLABORATION, OPTION AND LICENSE AGREEMENT
This First Amendment (the “Amendment”) is entered into by and among Janssen Pharmaceuticals, Inc. (“Janssen”), MeiraGTx UK II Limited and MeiraGTx Holdings plc (MeiraGTx UK II Limited and MeiraGTx Holdings plc, individually or collectively “MeiraGTx”), effective as of the date of last signature below (the “First Amendment Effective Date”) and amends that certain Collaboration, Option and License Agreement by and among Janssen and MeiraGTx, executed as of January 30, 2019 and effective as of February 25, 2019 (the “Collaboration Agreement”).
WHEREAS, unless otherwise expressly provided for in this Amendment, all capitalized words or phrases or other defined terms used in this Amendment will have the same meaning ascribed to them in the Collaboration Agreement.
WHEREAS, except to the extent expressly amended by this Amendment, the Collaboration Agreement remains in full force and effect.
NOW, THEREFORE, in consideration of the mutual promises and obligations contained herein, the parties, intending to be legally bound, hereby agree as follows:
		1.
	Amendment.

The table in Section 10.6(a)(i) (“10.6 Development Milestone Payments;” “(a) Clinical IRD Products;” “(i) RPGR Product”) shall be deleted and replaced in its entirety with the following table:
		(i)
	RPGR Product

	Development Milestone Event 
	Development Milestone Payment (USD) 

	[***]
	[***]

	[***]
	[***]

	[***]
	[***]

	[***]
	[***]

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		2.
	Remainder of Agreement. Except as expressly provided in this Amendment, the Collaboration Agreement shall continue to be in full force and effect in accordance with the terms and conditions thereof, and is hereby ratified, adopted, approved and

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confirmed.  From and after the date hereof, each reference to the Collaboration Agreement in any other instrument or document shall be deemed a reference to the Collaboration Agreement as amended hereby unless the context otherwise requires.
		3.
	Successors and Assigns. This Amendment shall be binding upon the parties hereto and their respective executors, administrators, legal representatives, heirs, successors and permitted assigns, and shall inure to the benefit of the parties hereto and, except as otherwise provided herein, their respective executors, administrators, legal representatives, heirs, successors and permitted assigns.

		4.
	Severability. In case any one or more of the provisions contained in this Amendment or any application thereof shall be invalid, illegal or unenforceable in any respect, the validity, legality and enforceability of the remaining provisions contained herein and other application thereof shall not in any way be affected or impaired thereby.

		5.
	Counterparts. This Amendment may be executed in one or more counterparts, each of which shall be deemed an original, and all of which taken together shall be deemed to constitute one and the same single instrument. Signature pages of this Amendment exchanged by facsimile or other electronic transmission will be deemed to be as effective as an original executed signature page.

		6.
	Governing Law. This Amendment, the rights and obligations of the parties hereto, and any claims or disputes relating thereto shall be governed by and construed in accordance with the provisions of Section 18.2 of the Collaboration Agreement and shall apply as if expressly set out in this Amendment.

[Signature Page Follows]
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IN WITNESS WHEREOF, the undersigned have executed this Amendment effective as of the date of last signature below.
	JANSSEN PHARMACEUTICALS, INC.
	MEIRAGTX UK II LIMITED

	By:
	/s/ Sarah Brennan
	By:
	/s/ Rich Giroux

	Name:
	Sarah Brennan
	Name:
	Rich Giroux

	Title:
	VP, New Bus. Develop. and Alliance Mgmt.
	Title:
	CFO and COO

	Date:
	December 16, 2021
	Date:
	December 16, 2021

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	MEIRAGTX HOLDINGS PLC
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	By:
	/s/ Rich Giroux
	​
	​

	Name:
	Rich Giroux
	​
	​

	Title:
	CFO and COO
	​
	​

	Date:
	December 16, 2021
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​Exhibit 10.35
MEIRAGTX HOLDINGS PLC
DEFERRED COMPENSATION PLAN FOR NON-EMPLOYEE DIRECTORS
1.Purpose and Effective Date. The purpose of the Plan is to provide the non-employee members of the Board of Directors (the “Board”) of MeiraGTx Holdings plc (the “Company”), with an opportunity to defer payment of all or a portion of their Restricted Share Units. The Plan shall be effective as of December 17, 2021 (the “Effective Date”).
2.Definitions. The following terms shall have the meanings given in this section unless a different meaning is clearly implied by the context:
(a)“Change in Control” shall have the same meaning as defined in the Equity Plan as in effect on the Effective Date; provided, that, for purposes of the Plan, in no event will a Change in Control be deemed to have occurred if the transaction is not also a “change in control event” under Section 409A.
(b)“Code” means the Internal Revenue Code of 1986, as amended.
(c)“Compensation Committee” means the Compensation Committee of the Board.
(d)“Deferred Compensation Account” means an account maintained for each Director who makes a deferral election as described in Section 4.
(e)“Deferred Share Unit” means an economic unit equal in value to one Ordinary Share (or fraction thereof) that is received by a participant pursuant to the Plan and provides for the deferred receipt of compensation.
(f)“Director” means a non-employee member of the Board.
(g)“Equity Plan” means the MeiraGTx Holdings plc 2018 Incentive Award Plan, as it may be amended or restated from time to time, or, to the extent applicable, any future or successor equity compensation plan of the Company.
(h)“Fair Market Value” means “Fair Market Value” as defined in the Equity Plan.
(i)“Ordinary Shares” means the ordinary shares of the Company.
(j)“Plan” means this MeiraGTx Holdings plc Deferred Compensation Plan for Non-Employee Directors.
(k)“Plan Administrator” means the Compensation Committee or its designee.
(l)“Plan Year” means a calendar year.
(m)“Restricted Share Unit” means “Restricted Share Unit” as defined in the Equity Plan and granted to a Director for serving as a Director, and includes any dividend equivalent rights associated with the Restricted Share Unit.
(n)“Section 409A” means Section 409A of the Code.
(o)“Separation from Service” means a “separation from service” within the meaning of Section 409A.
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3.Eligibility. All Directors who are not employees of the Company or any subsidiary of the Company shall be eligible to participate in the Plan.
	4.
	Election to Defer Restricted Share Units.

(a)Manner and Amount of Deferral Election. A participant may elect to defer receipt of all or a specified portion of such participant’s Restricted Share Units by giving written notice on an election form provided by the Plan Administrator. A participant’s election to defer is irrevocable and may not be changed, except as may be provided in the election form.
(b)Time of Election. Elections to defer Restricted Share Units shall be made at the following times:
(i)A Director may elect to defer Restricted Share Units at such time or times during the calendar year as permitted by the Plan Administrator. Such election shall be effective, as applicable, for Restricted Share Units granted in the following calendar year or years.
(ii)A nominee for election to Director (who is not at the time of nomination a sitting Director and was not previously eligible to participate in the Plan) may elect to defer Restricted Share Units no later than 30 days after the date of the Director’s commencement of service as a Director. Such deferral election shall be effective, as applicable, for Restricted Share Units granted following the later of (A) the date of the Director’s commencement of service as a Director, and (B) the date an irrevocable election form is filed with the Company.
(c)Duration of Deferral Election. Unless otherwise permitted by the Plan Administrator and specified in an applicable election form, a deferral election will only apply to one Plan Year and a participant must make a new deferral election with respect to each Plan Year that the participant decides to defer Restricted Share Units. Notwithstanding the foregoing, the Plan Administrator may provide, pursuant to the terms of an approved election form, that such deferral election shall carry forward from year-to-year and continue to apply to Restricted Share Units granted in subsequent years until the participant makes a new deferral election with respect to a Plan Year.
5.Deferred Compensation Accounts. The Company shall establish on its books and records a Deferred Compensation Account for each participant, as provided below.
(a)Crediting of Restricted Share Units. Deferred Restricted Share Units shall be credited to the participant’s Deferred Compensation Account in an equal amount of Deferred Share Units on the date the Restricted Share Units would otherwise have been granted. The Deferred Share Units related to such deferred Restricted Share Units shall be subject to the same vesting or other forfeiture restrictions that would have otherwise applied to such Restricted Share Units. In the event the participant forfeits Deferred Share Units in accordance with the foregoing, the participant’s Deferred Compensation Account shall be debited for the number of Deferred Share Units forfeited.
(b)Dividend Equivalents. Each Deferred Share Unit credited to a participant’s Deferred Compensation Account shall carry with it a right to receive dividend equivalents in respect of the Ordinary Share underlying such Deferred Share Unit. As of a dividend payment date, a participant’s Deferred Compensation Account will be credited with that number of additional Deferred Share Units (“Additional Deferred Share Units”) equal to the amount of any ordinary cash dividend paid by the Company on the number of Ordinary Shares equivalent to the number of Deferred Share Units in the Deferred Compensation Account as of the record date for the dividend, divided by the Fair Market Value 
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of one Ordinary Share on the dividend payment date. An Additional Deferred Share Unit will be subject to the same vesting or other forfeiture restrictions that apply to the corresponding Deferred Share Unit. The dividend equivalent right associated with a Deferred Share Unit shall remain outstanding until, and any Additional Deferred Share Unit will be delivered at the same time as, the delivery to the participant of the Ordinary Share underlying, or cash settlement of, the corresponding Deferred Share Unit. If a Deferred Share Unit is forfeited, any corresponding Additional Deferred Share Unit will also be forfeited and the applicable Deferred Compensation Account will be debited for the Additional Deferred Share Units forfeited.
(c)Adjustment of Deferred Share Units. If the number of outstanding Ordinary Shares is increased or decreased or the Ordinary Shares are changed into or exchanged for a different number or kind of shares or other securities of the Company on account of any recapitalization, reclassification, share split, reverse split, combination of shares, exchange of shares, share dividend, or other distribution payable in capital shares, or other increase or decrease in such shares effected without receipt of consideration by the Company occurring after the Effective Date, the Plan Administrator will make appropriate adjustments to (i) the number and kind of securities for which Deferred Share Units are outstanding, and (ii) the number of Deferred Share Units credited to each participant’s Deferred Compensation Account.
	6.
	Payment of Deferred Compensation.

(a)Distributions. Payment from the Deferred Compensation Account of Deferred Share Units corresponding to a participant’s deferral election for a given Plan Year shall be made in one lump sum on (or during) the earliest to occur of:
		(i)
	the 90 days following the participant’s Separation from Service;

		(ii)
	immediately prior to, on or within 30 days following a Change in Control, provided that the participant’s Separation from Service has not occurred prior to the Change in Control; or

		(iii)
	the participant’s death.

Notwithstanding anything to the contrary in the Plan, if, on the date of the participant’s Separation from Service, the participant is a “specified employee” within the meaning of Section 409A, the payment will occur on the later to occur of (x) the scheduled distribution date and (y) the first day of the seventh month following the date of the participant’s Separation from Service or, if earlier, the date of the participant’s death.
(b)Medium of Payment. Payments from the Deferred Compensation Account shall be made in whole shares for each whole Deferred Share Unit, and in cash for any fractional Deferred Share Unit; provided, that, the Compensation Committee may choose in its discretion to pay the participant cash in lieu of all or a portion of the Ordinary Shares. If a Deferred Share Unit (including a fraction thereof) is paid in cash, the amount of cash paid with respect to the Deferred Share Unit (or fraction thereof) will equal the Fair Market Value of an Ordinary Share (or fraction thereof) on the day immediately preceding the payment date.
7.Unfunded Promise to Pay; No Segregation of Funds or Assets. Nothing in the Plan shall require the segregation of any assets of the Company or any type of funding by the Company, it being the intention of the parties that the Plan be an unfunded arrangement for federal income tax purposes. No participant shall have any rights to or interest in any specific assets or Ordinary Shares by reason of the 
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Plan, and any participant’s rights to enforce payment of the obligations of the Company hereunder shall be those of a general creditor of the Company.
8.Non-assignability; Beneficiary Designation. The right of a participant to receive any unpaid portion of the participant’s Deferred Compensation Account shall not be assigned, transferred, pledged or encumbered or subjected in any manner to alienation or anticipation. However, in the event of a participant’s death, the Company will pay the unpaid portion of the participant’s Deferred Compensation Account to the participant’s designated beneficiaries. If the participant fails to complete a valid beneficiary designation, the participant’s beneficiary will be the participant’s estate.
9.Administration. The Plan will be administered under the supervision of the Plan Administrator. The Plan Administrator will prescribe guidelines and forms for the implementation and administration of the Plan, interpret the terms of the Plan, and make all other substantive decisions regarding the operation of the Plan. The Plan Administrator’s decisions in its administration of the Plan are conclusive and binding on all persons.
10.Construction. The laws of the Cayman Islands shall govern all questions of law arising with respect to the Plan, disregarding any choice-of-law principles requiring the application of a jurisdiction’s laws other than the Cayman Islands. The Plan is intended to be construed so that participation in the Plan will be exempt from Section 16(b) of the Securities Exchange Act of 1934, as amended, pursuant to regulations and interpretations issued from time to time by the Securities and Exchange Commission. If any provision of the Plan is held to be illegal or void, such illegality or invalidity shall not affect the remaining provisions of the Plan, but shall be fully severable, and the Plan shall be construed and enforced as if the illegal or invalid provision had never been inserted. This document constitutes the entire Plan, and supersedes any prior oral or written agreements on the subject matter hereof.
11.Section 409A; Changes in Tax Law. The Plan is intended to comply with Section 409A and any regulations and guidance thereunder such that no adverse tax consequences or penalties under Section 409A apply and shall be interpreted and operated in accordance with such intent. Neither the Company, its affiliates, the Board, nor the Compensation Committee (a) makes any representation or warranty with respect to the tax treatment of the Plan or benefits provided under the Plan, (b) will have any obligation to take any action to prevent the assessment of any excise tax or penalty on any participant under the Code, or (c) will have any liability to any participant or other person or entity for such tax or penalty or for any early, retroactive or additional tax or penalty under any provision of the Code enacted or revised after the Effective Date. Notwithstanding any provision of the Plan to the contrary, if the Plan Administrator determines that any amounts payable under the Plan will have adverse tax consequences to any participant under any provision of the Code that is enacted or revised after the Effective Date and changes the tax treatment of the benefits provided by the Plan, the Plan Administrator may (without any obligation to do so or to indemnify any participant for failure to do so), without any participant’s consent, adopt such amendments to the Plan or take such other actions that the Plan Administrator determines to be necessary or appropriate to preserve the intended tax treatment of the benefits provided by the Plan, to preserve the economic benefits of the Plan or benefits provided under the Plan or to avoid less favorable tax consequences for any participant or the Company, in each case, to the extent the Plan Administrator reasonably determines is permitted under then-applicable law. The nature and implementation of any such amendments or other actions will be determined unilaterally by the Plan Administrator in its discretion.
12.Claw-back. All awards of Deferred Share Units under the Plan will be subject to mandatory repayment by the participant to the Company to the extent the participant is, or in the future becomes, subject to any Company or affiliate “claw-back” or recoupment policy that is adopted to comply with the requirements of any applicable law, rule, regulation or otherwise, or any law, rule, or regulation that imposes mandatory recoupment, under circumstances set forth in such law, rule or regulation.
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13.Amendment and Termination. The Board may amend, suspend, or terminate the Plan at any time and for any reason. No amendment, suspension, or termination will, without the consent of the participant, materially impair rights or obligations under any Deferred Share Units previously awarded to the participant under the Plan, except as provided below. The Board may terminate the Plan and distribute the Deferred Compensation Accounts to participants in accordance with and subject to the rules of Treas. Reg. Section 1.409A-3(j)(4)(ix), or successor provisions, and any generally applicable guidance issued by the Internal Revenue Service permitting such termination and distribution.
14.Incorporation of Equity Plan. The Plan is established under and subject to the terms of the Equity Plan. Deferred Share Units issued to, and Ordinary Shares paid to, participants under the Plan shall be issued and paid from the Equity Plan and subject to its terms. Notwithstanding the foregoing, if there is a conflict between the terms of the Plan and the Equity Plan, the terms of the Plan will control.
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