Document:

Exhibit 4.11.6

    

    

      	
              AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

            	 	
              1. CONTRACT ID CODE

            	 	
              PAGE OF PAGES

            
	 	 	 	 	
              1

            	
              8

              

            
	
              2. AMENDMENT/MODIFICATION NO.

            	
              3. EFFECTIVE DATE

            	
              4. REQUISITION/PURCHASE REQ. NO.

            	
              5. PROJECT NO. (If applicable)

            
	
              P00005

            	 	
              See Block 16C

            	
              OS254380

            	 	 	 	 
	
              6. ISSUED BY

            	
              CODE   

            	
              ASPR-BARDA

            	
              7. ADMINISTERED BY (If other than Item 6)

            	
              CODE

            	
              ASPR-BARDA01

            
	 	 	 	 	 	 
	
              ASPR-BARDA

            	
              ASPR-BARDA

            	 	 	 	 
	
              200 Independence Ave., S.W.

            	
              330 Independence Ave, SW, Rm G644

            
	
              Room 640-G

            	
              Washington DC 20201

            
	
              Washington DC 20201

            	 	 	 	 	 
	 	 	 	 	 	 
	
              8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP Code)

            	
              (x)

            	
              9A. AMENDMENT OF SOLICITATION NO.

            
	 	 	 	 	 	 	 	 	 	 
	
              MEDIWOUND LTD 1477616

            	 	 	 	 	 	 	 	 	 
	
              MEDIWOUND LTD

            	
              42 HAYARKON

            	 	 	
              9B. DATED (SEE ITEM 11)

            
	
              42 HAYARKON

            	 	 	 	 	 	 	 	 	 
	
              YAVNE     00812

            	 	 	
              x

            	
              10A. MODIFICATION OF CONTRACT/ORDER NO.

            
	 	 	 	 	
              HHSO100201500035C

            	 	 	 	 
	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	
              10B. DATED (SEE ITEM 13)

            	 	 	 	 
	
              CODE      1477616

               

            	 	
               FACILITY CODE

               

            	 	
              09/29/2015

               

            	 	 	 	 
	
              11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS

            

      	
              ☐

            	
              The above numbered solicitation is amended as set forth in Item 14. The hour and date specified for receipt of Offers      ☐ is extended.   ☐ is not extended.

            
	 	
              Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended , by one of the following methods: (a) By completing Items 8 and 15, and returning ________ copies of the amendment;
                (b) By acknowledging receipt of this amendment on each copy of the offer submitted ; or (c) By separate letter or telegram which includes a reference to the solicitation and amendment numbers. FAILURE OF YOUR ACKNOWLEDGEMENT TO BE RECEIVED
                AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER. If by virtue of this amendment you desire to change an offer already submitted , such change may be made by
                telegram or letter, provided each telegram or letter makes reference to the solicitation and this amendment, and is received prior to the opening hour and date specified.

            

      	
              12. ACCOUNTING AND APPROPRIATION DATA (If required)

            	
              Net Increase:

            	
              $5,537,538.00

            
	
              2020.1991073.25106

              

            	 	 
	
              13. THIS ITEM ONLY APPLIES TO MODIFICATION OF CONTRACTS/ORDERS. IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

               

            
	
              CHECK ONE

            	
              A. THIS CHANGE ORDER IS ISSUED PURSUANT TO: (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT ORDER NO. IN ITEM 10A.

               

            
	 
	 	
              B. THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office, appropriation date, etc.)
                SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b).

               

            
	
              X

            	
              C. THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:

              
                FAR 52.243-2 (Alt V) Changes - Cost , FAR 43.103(a) - By Mutual Agreements of the Parties

              

            
	 	
              D. OTHER (Specify type of modification and authority)

               

            
	
              E. IMPORTANT: Contractor ☐ is not.  ☒ is required to sign this document and return      1      copies to the issuing office.

            

       14. DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter where feasible.)

       

        

       
      
        	
                Tax ID Number:

              	
                C0-0000387

              
	DUNS Number:	532040334

        The purpose of this modification is to accomplish the following:

        
          	
                  1.

                	
                  ARTICLE B.5. ADVANCE UNDERSTANDINGS, is modified to add several advance understandings.

                

        

      

       
      
        
          
            	
                    2.

                  	
                    
                      ARTICLE B.3. OPTION PRICES, is modified to add and fund CLINs 0006A; 0006B, and 0006C, and 0007A and 0007B.

                    

                  

          

          
            
              	
                      3.

                    	
                      
                        ARTICLE C.1. STATEMENT OF WORK, is modified to add an addendum.

                      

                    

            

            
              
                	
                        4.

                      	
                        
                          SECTION J, LIST OF ATTACHMENTS, is modified to add an addendum.

                        

                      

              

            

          

        

      

       
       
         
          
            	
                    5.

                  	
                    
                      The total estimated cost of the contract is increased by $5,175,269.

                    

                  

          

           
           
            
              	
                      6.

                    	
                      
                        The total fixed fee of the contract is increased by $362,269.

                      

                    

            

             
             
                   
                	
                        7.

                      	 
                         
                          The total cost plus fixed fee amount of the contract is increased by $5,537,538 from Continued ...

                        

                      

              

            

          

        

         

      Except as provided herein, all terms and conditions of the document referenced in Item 9 A or 10A, as heretofore changed, remains unchanged and in full force and effect.

      	
              15A. NAME AND TITLE OF SIGNER (Type or print)

            	
               16A. NAME AND TITLE OF CONTRACTING OFFICER (Type or print)

            
	 	 
	
              Sharon Malka, Chief Executive Officer       Yaron Meyer, General Counsel & Corporate Secretary

            	
               GEORGE J. KEANE

            	 
	
              15B. CONTRACTOR/OFFEROR

            	
              
                15C. DATE SIGNED+

              

            	
               16B. UNITED STATES OF AMERICA

            	
              16C. DATE SIGNED

            
	
                  /s/Sharon Malka    /s/Yaron Meyer 

                

            	
              2/28/2020

            	
              
                            /s/George J. Keane

              

            	
              02/28/2020

            
	
              (Signature of person authorized to sign)

            	 	
              (Signature of Contracting Officer)

            	 

      	
              
                Previous edition unusable

              

            	
              
                STANDARD FORM 30 (REV. 11/2016)

              

            
	
              

              

            	
              
                Prescribed by GSA FAR 

                

              

            
	 	
              (48 CFR) 53.243

            

       

      
        
          
            

        

        	 	 	 	 
	
                CONTINUATION SHEET

              	
                REFERENCE NO. OF DOCUMENT BEING CONTINUED

              	
                PAGE OF

              
	
                HHSO100201500035C/P00006

              	
                2

              	
                8

                

              

        NAME OF OFFEROR OR CONTRACTOR

        MEDIWOUND LTD 1477616

        	
                ITEM NO.

                (A)

              	
                SUPPLIES/SERVICES

                (B)

              	
                QUANTITY

                (C)

              	
                UNIT

                (D)

              	
                UNIT PRICE

                (E)

              	
                AMOUNT

                (F)

              
	 	
                
                  $76,406,048 to $81,943,586.

                

              	 	 	 	 
	 	
                
                  8.  The total ultimate contract value is increased by $5,537,538 from $80,853,761 to $86,391,299. 

                

              	 	 	 	 
	 	
                See supplemental pages for remainder of modification. All other terms and conditions of this contract remain in full force and effect.

              	 	 	 	 
	 	
                
                  Delivery: 06/30/2024

                

              	 	 	 	 
	 	
                
                  Delivery Location Code: HHS

                

              	 	 	 	 
	 	
                
                  HHS

                

              	 	 	 	 
	 	
                
                  200 Independence Avenue, SW

                

              	 	 	 	 
	 	
                Washington DC 20201 US

              	 	 	 	 
	 	
                

                

              	 	 	 	 
	 	
                Appr. Yr.: 2020 CAN: 1991073 Object Class: 25106

              	 	 	 	 
	 	
                
                  Period of Performance: 09/29/2015 to 06/30/2024

                

              	 	 	 	 
	 	 	 	 	 	 
	 	
                
                  Add Item 9 as follows:

                

              	 	 	 	

              
	 	 	 	 	 	 
	 9	
                
                  CLIN 0006A ($1,015,002 total cost and $71,050 fixed fee, total CLIN cost $1,086,052), CLIN 0006B ($3,241,917 total cost and $226,934 fixed fee, total CLIN cost
                    $3,468,851) , CLIN 0006C ($15,000 total cost, $1,050 fixed fee, total CLIN cost $16,050), CLIN 0007A
                    ($32,000 total cost, $2,240 fixed fee, total CLIN cost $34,240), CLIN 0007B ($871,350 total cost and $60,995 fixed fee, total CLIN cost $932,345).

                

              	 	 	 	$5,537,538.00
	 	
                
                  Obligated Amount: $5,537,538.00

                

              	 	 	 	 
	 	
                

                

              	 	 	 	 
	 	
                

                

              	 	 	 	 
	 	
                

                

              	 	 	 	 
	 	 	 	 	 	 
	 	
                

                

              	 	 	 	 
	 	
                

                

              	 	 	 	 
	 	
                

                

              	 	 	 	 
	 	
                

                

              	 	 	 	 
	 	
                

                

              	 	 	 	 
	 	 	 	 	 	 
	 	
                

                

              	 	 	 	 
	 	
                

                

              	 	 	 	 
	 	
                

                

              	 	 	 	 
	 	
                

                

              	 	 	 	 
	 	
                

                

              	 	 	 	 
	 	 	 	 	 	 
	 	 	 	 	 	 

        	
                NSN 7540-01-152-8067

              	
                OPTIONAL FORM 336 (4-86)

              
	 	
                Sponsored by GSA

              
	 	
                FAR (48 CFR) 53.110

              

      

       

      

    

    
      
        

    

     

    

     

    

    	
            Contract No. HHSO100201500035C

            Modification No. 0006

          	
            Continuation Sheet 

            Block 14

          	
            Page 3 of 8

          

    

    

    ARTICLE B.3. OPTION PRICES, is modified to add the following: 

    

    

    	
            Cost Reimbursement

          
	
            CLIN

          	
            Period of Performance

          	
            Supplies/Services

          	
            Total Est. Cost

          	
            Fixed Fee (7%)

          	
            Total Cost Plus Fixed Fee

          
	
            0006 A

          	
            3/1/2020 –

            6/30/2024

          	
            Emergency Readiness for NexoBrid Deployment –– Procure shipment boxes (up to 890 units of 56L capacity Master Shippers) with temperature tales to enable CRT shipment of
              16,000 Nexobrid units in a staggered fashion to compliment quarterly Nexobrid procurements. Shipment box choice contingent upon COR approval.

             

            

          	
            $1,015,002

          	
            $71,050

          	
            $1,086,052

          
	
            0006 B

          	
            3/1/2020 –

            6/30/2024

          	
            Emergency Readiness for NexoBrid Deployment –– Monthly Maintenance to cover up to 36 months duration after final Nexobrid procurement (not to exceed $58,900/month) for
              shipment boxes to be ready for shipment from Sentry at CRT.

             

            Access and management for SNS and/or BARDA annual inventory audit (1 full business day/year) Audit will include both Nexobrid units and shipment boxes.

          	
            $3,241,917

          	
            $226,934

          	
            $3,468,851

          
	
            0006 C

          	
            3/1/2020 –

            6/30/2024

          	
            Emergency Readiness for NexoBrid Deployment – At least one drill dry run exercise executed by the Contractor’s VMI vendor to fully package 50 Credo boxes of Nexobrid to
              fully ready for deployment.

             

            

          	
            $15,000

          	
            $1,050

          	
            $16,050

          

    

    

    
      
        

    

     

    

    

    	
            Contract No. HHSO100201500035C

            Modification No. 0006

          	
            Continuation Sheet 

            Block 14

          	
            Page 4 of 8

          

     

    	
            0007 A

          	
            3/1/2020 –

            6/30/2024

          	
            Emergency Deployment – Vendor executes Pick and Pack for up to 16,000 NexoBrid treatment units (not to exceed $2 per unit) as instructed by SNS to be ready for CRT
              shipment of 3,150 units in 24 hours and the rest of the 12,850 units NLT in 72 hours.

          	
            $32,000

          	
            $2,240

          	
            $34,240

          
	
            0007 B

          	
            3/1/2020 –

            6/30/2024

          	
            Emergency Deployment – As directed by SNS upon their notification, Vendor ships at CRT using either their established shipping contract(s), or maintains readiness for
              pick up by SNS-managing shipment mechanism(s) for up to all 16,000 units of Nexobrid.

          	
            $871,350

          	
            $60,995

          	
            $932,345

          

     

    

    ARTICLE B.5. ADVANCE UNDERSTANDINGS, is modified to add paragraphs l through p as follows: 

     

    	

          	l.	
            In a mass casualty situation, which does not require a national emergency declaration, upon consultation and request for use of NexoBrid, the Contractor could submit a request for COA and justification to potentially trigger all or part of
              the emergency deployment strategies outlined in CLIN 7.

          

     

    	

          	m.	
            The cost estimate listed in CLIN 7 represents the best estimate. Upon triggering of deployment actions the Contractor may seek additional reimbursement for actual costs incurred by providing justification and approval by CO.

          

     

    	

          	n.	
            Notification of Release of Product - Notification to release product(s) under this Contract shall be provided in writing to the Contractor by the CO, or by an authorized representative designated by the CO.

          

     
    	

          	o.	
            To clarify the term ‘substantial delivery’, it is hereby defined to indicate product delivery and acceptance of at least two (2) deliveries, and cover at least three (3) production manufacturing lots. As such the first invoice for the
              delivery of the product can only be submitted upon acceptance by BARDA of at least 2 deliveries of the product with at least three (3) manufactured lots per delivery.

          

     

    “Acceptance” signifies that the requested product meets all the specifications as defined in the QA contract and therefore can be accepted by BARDA’s Quality
      Group, who represents the USG check for acceptance of deliverables for both quantity and quality. Acceptance will be contingent upon receipt of undamaged product units manufactured under GMP conditions and maintained within the specified shipping
      conditions. BARDA Quality will count all dosages and ensure that the product is maintained within temperature during transport and all deviations have been closed prior to acceptance.

    
      
        

    

      

    

    

    	
            Contract No. HHSO100201500035C

            Modification No. 0006

          	
            Continuation Sheet 

            Block 14

          	
            Page 5 of 8

          

       

    Delivery term - Shipping and handling fees up to delivery of the products are included within the negotiated unit purchase price. NexoBrid price is including
      delivery at point “DAP” (incoterms 2000), at Sentry’s warehouse based in Indianapolis, U.S.

    

    

    	

          	p.	
            Consistent with FAR 52.227-14, the BEACON model (the “Model”) developed under this contract will be owned by USG. The USG holds an unlimited rights license to that model. However, BARDA will
              provide MediWound with a limited rights license to use of the current version of the Model developed under the Contract with to meet the corporate needs for marketing NexoBrid (the “USG/MediWound License”). The USG/MediWound License is
              limited to use by MediWound, and may not be assigned by MediWound to any other parties without the express written authorization of the USG’s contracting officer.

            
               

              To further expand the utility of the model for evaluating the combined effects with other MCMs, BARDA may use this model with additional BARDA prime contractors. Future versions of the model, solely supported
                by BARDA funding, will be made accessible to all product development partners equally. It is BARDA’s intent to make iterations of the model available publically.

            

          

    

    ARTICLE C.1. STATEMENT OF WORK, is modified to read as follows:

     

    Independently and not as an agent of the Government, the Contractor shall furnish all the necessary services, qualified personnel, material, equipment, and facilities not otherwise provided by the
      Government as needed to perform the Statement of Work dated September 28, 2015, as amended on January 29, 2017 (via Modification 3), and amended February 21, 2020 (herein); and set forth in SECTION J - List of Attachments, attached hereto and made a
      part of the contract.

    

    

    SECTION J – LIST OF ATTACHMENTS, is modified to add the following:

     

    1.  Statement of Work, amendment dated 2/21/2020.

    
      
        

    

    

    

    ATTACHMENT 1

     

    STATEMENT OF WORK 02/21/2020

    

    

    CLINS 0006 and 0007 are hereby added to the Statement of Work:

     

    1.  CLIN 0006 SOW

     

    The proposed SOWs for CLIN 0006A, 6B and 6C are contained in the tables below. Dates are TBD pending consultation with the BARDA PO.

     

    Table 1: CLIN 0006 SOW

     

    	
            WBS

          	
            Title

          	
            Description

          	
            Milestone

          	
            Deliverables

          	
            Cost

          	
            Delivery Date (est.)

          	
            CLIN

          
	
            6

          	
            CLIN 0006A

          	
            Emergency Readiness Tasks - Materials

          	 	
            0006A

          
	
            6.7

          	
            Procurement

          	 	 	 	 	 	
            0006A

          
	
            6.7.1

          	
            Acquisition

          	 	 	 	 	 	
            0006A

          
	
            6.7.1.1

          	
            Shipment Containers

          	
            Procure shipment containers (up to 890 units of 56L capacity) with Temperature tales to enable CRT shipment of 16,000 NexoBrid units in a staggered fashion to compliment
              quarterly NexoBrid procurements.

              

            

            Shipment containers choice contingent upon COR approval.

             

            The total costs encompass box procurement of up to 890 CREDO (or equivalent) shippers on a staggered schedule in 3 stages.

          	
            Start & end of shipment containers deliveries.

          	
            Shipment box procurement/delivery schedule, with maintenance costs.

             

            Shipment containers deliveries

          	
            $1,086,053

          	
            Q1/2020

            through Q1/2021

          	
            0006A

          

      

    	
            WBS

          	
            Title

          	
            Description

          	
            Milestone

          	
            Deliverables

          	
            Cost

          	
            Delivery Date (est.)

          	
            CLIN

          
	
            6

          	
            CLIN 0006B

          	
            Emergency Readiness Tasks - Maintenance

          	 	 	 	 	
            0006B

          
	
            6.7

          	
            Procurement

          	 	 	 	 	 	
            0006B

          
	
            6.7.2

          	
            Sustainment

          	 	 	 	 	 	
            0006B

          
	
            6.7.2.1

          	
            Maintenance of Shipment Boxes

          	
            Monthly Maintenance charges to cover 36 months duration after final NexoBrid procurement for shipment boxes to be ready for shipment from Sentry at CRT. Period -
              01/01/2020 through 06/30/2024.

             

            Costs are calculated based on storage of the boxes over the contract period of performance, assuming a staggered procurement schedule as described in WBS 6.7.1.1.

             

          	
            Start & end of maintenance of shipment boxes.

          	
            Verification of box storage readiness

             

            Box Maintenance Plan SOP

             

            

             Shipment box deliveries and storage.

             

          	
            $3,421,051

          	
            Through June 30

            2024

          	
            0006B

          

    

    

    
      HHSO100201500035C

      Modification 0006

      Page 6 of 8 

      Attachment 1 – Statement of Work

       

    
      
        

    

    

    

    	
            WBS

          	
            Title

          	
            Description

          	
            Milestone

          	
            Deliverables

          	
            Cost

          	
            Delivery Date (est.)

          	
            CLIN

          
	 	 	
            Formal SOPs will be developed at MediWound’s VMI vendor for assembly, storage and maintenance of the boxes.

          	 	
            Completion of yearly audit.

          	 	 	 
	
            6.7.2.2

          	
            BARDA/SNS

            audit

          	
            Access and Management for SNS and/or BARDA annual inventory audit (@ 1 full business day/year). Audit will include both NexoBrid units and shipment boxes

          	
            Start & end of maintenance of shipment boxes.

          	
            Completion of yearly audit.

          	
            $42,800

          	
            Through June 30

            2024

          	
            0006B

          

      

    	
            WBS

          	
            Title

          	
            Description

          	
            Milestone

          	
            Deliverables

          	
            Cost

          	
            Delivery Date (est.)

          	
            CLIN

          
	
            6

          	
            CLIN 0006C

          	
            Emergency Readiness Tasks – Emergency Preparedness Procedures / Exercise

          	 	
            0006C

          
	
            6.7

          	
            Procurement

          	 	 	 	 	 	
            0006C

          
	
            6.7.3

          	
            Sustainment

          	 	 	 	 	 	
            0006C

          
	
            6.7.3.1

          	
            Emergency Preparedness Procedures

          	
            Operational SOPs developed at MediWound’s VMI vendor, including:

             

            •       An emergency communication system with the Strategic National Stockpile

            •       Evidence of emergency shipment mechanism(s) by Sentry to move the product in the stated amounts and timeframes

            •       Development of an emergency exercise design protocol in coordination with Sentry/BARDA/SNS

          	
            SOPs and emergency protocol developed and approved.

          	
            Documents submitted to BARDA PO/CO.

          	 	 	
            0006C

          
	
            6.7.3.2

          	
            Emergency Preparedness Exercise

          	
            At least one drill dry run Exercise executed by MediWound’s VMI vendor to fully package 50 Credo boxes of NexoBrid to be ready for deployment

          	
            Completion of exercise.

          	
            Final report (After Action Report) submitted to BARDA PO/CO.

          	
            $16,050

          	
            Q4/20 20

          	
            0006C

          

       

    1. CLIN 0007 – EMERGENCY DEPLOYMENT TASKS

     

    CLIN 0007 has been structured into two distinct CLINs that can be authorized separately upon emergency/MCI:

     

    	
            Title

          	
            Description

          
	
            CLIN 0007A

          	
            Emergency Deployment Preparation

          
	
            CLIN 0007B

          	
            Emergency Deployment and Shipping

          

    

    

    
      HHSO100201500035C

      Modification 0006

      Page 7 of 8 

      Attachment 1 – Statement of Work

      
        
          

      

         

    Either CLIN would only be authorized in the event of an emergency upon notification from the SNS Director/Designee. MediWound will provide immediate notification to the BARDA CO/COR and BARDA/RQA (who
      manage the Quality Agreement). CLIN 0007A describes the packing operations that would take place at MediWound’s VMI vendor after the request is received from BARDA/SNS. CLIN 0007B would be authorized if the actual shipping of NexoBrid were to be
      conducted by the VMI vendor rather than by SNS.

     

    1.1 CLIN 0007 SOW

     

    The proposed SOWs for CLIN 0007A, and 7B are contained in the tables below. Dates are TBD pending consultation with the BARDA PO.

     

    Table 3: CLIN 0007 SOW

     
    	
            WBS

          	
            Title

          	
            Description

          	
            Milestone

          	
            Deliverables

          	
            Cost

          	
            Delivery Date (est.)

          	
            CLIN

          
	
            7

          	
            CLIN 0007A

          	
            Emergency Deployment Preparation

          	 	 	 	 	
            0007A

          
	
            7.7

          	
            Emergency Deployment

          	 	 	 	 	 	
            0007A

          
	
            7.7.1

          	
            Pick and pack

          	 	 	 	 	 	
            0007A

          
	
            7.7.1.1

          	
            Emergency Deployment

          	
            Vendor executes Pick and Pack for up to 16,000 NexoBrid treatment units as instructed by SNS to be ready for CRT shipment of 3,150 units in 24hr. and the rest of the
              12,850 units NLT in 72 hr.

          	
            Complete deployment.

          	
            Communication of “deployment ready status” made to BARDA/SNS

          	
            $34,240

          	 	
            0007A

          

      

    	
            WBS

          	
            Title

          	
            Description

          	
            Milestone

          	
            Deliverables

          	
            Cost

          	
            Delivery Date (est.)

          	
            CLIN

          
	
            7

          	
            CLIN 0007B

          	
            Emergency Deployment and Shipping

          	 	 	 	 	
            0007B

          
	
            7.7

          	
            Emergency Deployment

          	 	 	 	 	 	
            0007B

          
	
            7.7.2

          	
            Shipping

          	 	 	 	 	 	
            0007B

          
	
            7.7.1.2

          	
            Emergency Shipping

          	
            As directed by SNS upon their notification, Vendor ships at CRT using either their established shipping contract(s) and/or maintains readiness for pick up by
              SNS-managing shipment mechanism(s) for up to 16,000 units of NexoBrid.

            Assumed shipment of 890 boxes to the major cities in the furthest 4 corners of the continental US upon SNS guidance

          	
            Emergency shipment performed.

          	
            Emergency shipment completed

          	
            $932,345

          	 	
            0007B

          

    

    

    
      HHSO100201500035C

      Modification 0006

      Page 8 of 8 

      Attachment 1 – Statement of WorkExhibit 4.16

      

     

    
    Amendment No. 1 to Settlement Agreement and Mutual General Release

    

    

    This Amendment No.1 to a Settlement Agreement and Mutual General Release (“Amendment”) is made effective of December 13, 2020 (the “Effective Date”) by end between Teva Pharmaceutical Industries Ltd. ("Teva"), on the one hand, and MediWound Ltd. ("MediWound"), on the other hand. Teva and MediWound are together referred to as the "Parties" and individually referred to as a
      “Party”.

     

    WITNESSETH:

     

    WHEREAS the Parties entered into a Settlement Agreement and Mutual General Release dated March 24, 2019, (the “Agreement”) to fully and finally settle all
      matters arising from and/or related to the their business relationship and the termination of such relationship, including without limitation the Asserted Claims, as such term is defined in the Agreement followed by Mediwound’s undertakings pursuant
      to that letter dated March 24, 2019 regarding Certain Indemnity in connection with the Settlement Agreement (the "Indemnification Letter");

    

    

    WHEREAS following discussions that were held between the Parties, the Parties have reached new understandings regarding the payment of the Revenue-Based Payments, as such term is defined in the
      Agreement, and wish to amend them, in accordance with the principles of Appendix A attached to this Amendment, and as more fully set forth herein;

    

    

    NOW, THEREFORE, in consideration of the mutual promises herein contained, it is agreed as follows:

    

    

    	1.	
            All capitalized terms not herein defined shall have the meaning ascribed to them in the Agreement.

          

    

    

    	2.	
            Section 3.2 shall be removed entirely from the Agreement and  shall be replaced with the following:

          

    "MediWound hereby undertakes to pay Teva:

     

    

    (i) an amount of US$ 3,000,004, in lieu of the Revenue-Based Payment for the calendar year 2019 (which was due to be paid on April 2020), which shall be paid as
      follows: an amount of US$1,000,000 to be paid within 3 business days after signing this Amendment; in addition, twelve quarterly payments in the amount of US$ 166,667 each during the period commencing on January 1, 2021 and ending on December 31,
      2023. Such payments will be made on or prior to the end of each calendar quarter, in which such payment is due. Such payments shall be performed regardless of any revenues, received or not received by MediWound; and

     

    

    (ii) commencing on January 1, 2021, an annual payment of US$1,000,000, payable on a quarterly basis (i.e., US$ 250,000 per quarter) (the "Contingent Payments"),
      unless MediWound will not recognize any revenues generated from the sale or license by MediWound or its Affiliate of the Licensed Products in a certain calendar quarter in which a payment is due, and in this case, MediWound shall not be obligated to
      pay Teva the Contingent Payment due for that quarter (the term "Licensed Product” shall have the meaning ascribed thereto in that certain License and Collaboration Agreement dated August 21, 2007, as amended, by and between MediWound and Teva, which
      definition is hereby incorporated by reference into this Amendment to constitute an integral part hereof); all, up to an aggregate amount equal to US$ 7,200,000 regardless of the  number of quarters required for purposes of the payment of such
      aggregate amount. Each Contingent Payment will be on or prior to the end of each calendar quarter, in which such payment is due. For the avoidance of doubt, it is hereby clarified that the Contingent Payment for a certain quarter shall be paid in the
      event that Mediwound shall have recognized revenues generated from the sale or license by MediWound or its Affiliate of the Licensed Products above 0 during such calendar quarter (regardless of the actual amount of such revenues).

    
      
        

    

     

    

    (iii) the Parties agree that MediWound shall have the right, upon 30 days advance written notice, to pay in advance  the balance of the Contingent Payments that
      have not been paid up to the date of such advance repayment, subject to the Parties' agreement on the present value of such balance of Contingent Payments."

    

    

    	3.	
            Section 3.3(ii) shall be removed from the Agreement and the Section 3.3(ii) shall be left intentionally blank.

          

    

    

    	4.	
            In Section 3.3(iii)(B) the reference will be amended from Section 3.2(i) to Section 3.2.

          

    

    

    	5.	
            All other terms and conditions of the Agreement shall apply to the Amendment and remain in full force and effect as detailed in the Agreement.

          

    

    

    	6.	
            In the event of any inconsistency or conflict between the provisions of the Agreement the provisions of this Amendment, this Amendment shall prevail and govern.

          

    

    

    	7.	
            It is hereby clarified that the Indemnification Letter remains in full force and effect without any change following this Amendment.

          

    

    

    The Parties have caused this Amendment to be duly authorized, executed, and delivered as of the Effective Date.

    

    

    [Signature Block Follows]

    
      
        

    

    

    

    IN WITNESS WHEREOF, this Settlement Agreement and Mutual General Release has been duly executed on the date herein above set forth:

     

    	
            MediWound Ltd.

             

            By: /s/Sharon Malka

            Name: Sharon Malka

            Title: Chief Executive Officer

             

            By: /s/Boaz Gur-Lavie

            Name: Boaz Gur-Lavie

            Title: Chief Financial Officer

          	
            Teva Pharmaceutical Industries Ltd.

             

            By:       /s/Eli Shani

            Name:  Eli Shani

            Title:    SVP, Business Development

             

            By:       /s/Eli Kalif

            Name:  Eli Kalif

            Title:    EVP, Chief Financial Officer

          

    

    

    [Signature Page to Amendment No. 1 to

    Settlement Agreement and Mutual General Release / 2020]

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