Document:

EX-10.16

 Exhibit 10.16 

January 27, 2017 
 Ideaya Biosciences, Inc.

 7000 Shoreline Court, Suite 350-1 

San Francisco, CA 94080 
 Attention: Lease Administrator 

Re:         7000 Shoreline Court, South San Francisco 

Ladies and Gentlemen: 
 Reference is made to
that certain Lease Agreement dated as of August 26, 2016 (as the same has been or may in the future be amended, the “Lease”), between ARE-SAN FRANCISCO NO. 17, LLC, a Delaware limited
liability company (“Landlord”), and IDEAYA BIOSCIENCES, INC., a Delaware corporation (“Tenant”), relating to the lease of the premises at the above-referenced address. All capitalized terms used herein without
definition shall have the meanings defined for such terms in the Lease. 
 Landlord and Tenant hereby acknowledge and agree that:
(i) the second sentence of Section 3(a) of the Work Letter is hereby deleted in its entirety and replaced with the following: “Landlord shall, at Landlord’s sole cost and expense, construct the third floor
control area and install fire sprinklers in the chemistry fume hoods, in a manner and using materials reasonably acceptable to Landlord”, (ii) Section 5(b)(1) of the Work Letter is hereby deleted and replaced with the
following: “1. A “Tenant Improvement Allowance” in the maximum amount of $501,020, which is included in the Base Rent set forth in the Lease, and”, (iii) Section 5(b)(2) of the Work Letter is
hereby deleted and replaced with the following: “an “Additional Tenant Improvement Allowance” in the maximum amount of $70 per rentable square foot in the Premises, or $1,136,380 in the aggregate, which shall, to the extent
used, result in the payment of TI Rent as set forth in Section 4(b) of the Lease”, and (iv) in addition to the Tenant Improvement Allowance and Additional Tenant Improvement Allowance, Landlord agrees to pay 50%
of the cost of that certain line item set forth as of the date of this letter agreement on the Budget (as defined in the Work Letter) as “Add/Alt#6 – Fume Hood Case Work Replacement (Like for
Like-3 Cabinets)”; provided, however, that if Tenant makes any Changes to the scope of such line item following of the date of this letter agreement, Tenant shall be required to pay any additional costs
associated with such Changes. Notwithstanding anything to the contrary contained herein or in the Lease, Tenant shall pay its portion of such cost of replacing the fume hood cabinets pursuant to the immediately preceding sentence as Excess TI Costs
for which Tenant is responsible in accordance with Section 5(d) of the Work Letter. Landlord shall be responsible for the compliance of the Premises and the Common Areas of the Project with Legal Requirements as of the
Commencement Date; provided, however, that if any compliance of the Premises or Common Areas is triggered as a result of any Changes made by Tenant after the approval of the TI Design Drawings, any additional costs incurred by Landlord in connection
with such compliance triggered as a result of such Change shall be included as part of TI Costs under Section 5(c) of the Work Letter. For the avoidance of doubt, the “HVAC” line item on the Budget includes the
cost of air balancing in the Premises (not including any additional costs incurred as a result of any Changes). 
 Except as amended and/or
modified by this letter agreement, the Lease is hereby ratified and confirmed and all other terms of the Lease shall remain in full force and effect, unaltered and unchanged by this letter agreement. In the event of any conflict between the
provisions of this letter agreement and the provisions of the Lease, the provisions of this letter agreement shall prevail. Whether or not specifically amended by this letter agreement, all of the terms and provisions of the Lease are hereby amended
to the extent necessary to give effect to the purpose and intent of this letter agreement. 

 Ideaya Biosciences, Inc. 

January 27, 2017 
 Page 2 

Please acknowledge your agreement to the terms of this letter agreement by countersigning below and returning two (2) executed originals
of this letter agreement to the undersigned. 
  

							
	 ARE-SAN FRANCISCO NO. 17, LLC,

a Delaware limited liability company

		
	By:    	 	 ALEXANDRIA REAL ESTATE EQUITIES, L.P.,

a Delaware limited partnership, managing member

			
		 	By:	 	 ARE-QRS CORP.,

a Maryland corporation, general partner

 

			
		
	By:	 	/s/ Eric S. Johnson
	lts:	 	 Eric S. Johnson
 Senior Vice President

RE Legal Affairs

 ACCEPTED AND AGREED TO: 
  

			
	IDEAYA BIOSCIENCES, INC.,
	a Delaware corporation
		
	By:	 	/s/ Yujiro Hata
	Name:	 	Yujiro Hata
	Title:	 	CEOEX-10.17

 Exhibit 10.17 

FIRST AMENDMENT TO LEASE 

THIS FIRST AMENDMENT TO LEASE (this “First Amendment”) is made as of May 31, 2018, by and between ARE-SAN FRANCISCO NO. 17, LLC, a Delaware limited liability company (“Landlord”), and IDEAYA BIOSCIENCES, INC., a Delaware corporation (“Tenant”). 

RECITALS 
 A.
Landlord and Tenant are parties to that certain Lease Agreement dated as of August 26, 2016, as amended by that certain letter agreement dated January 27, 2017 (as amended, the “Lease”). Pursuant to the Lease, Tenant
leases certain premises consisting of approximately 16,234 rentable square feet (“Original Premises”) in a building located at 7000 Shoreline Court, South San Francisco, California. The Original Premises are more particularly
described in the Lease. Capitalized terms used herein without definition shall have the meanings defined for such terms in the Lease. 

B. Landlord and Tenant desire, subject to the terms and conditions set forth below, to amend the Lease to, among other things, expand
the size of the Original Premises by adding that portion of the third floor of the Building consisting of approximately 7,340 rentable square feet, as shown on Exhibit A attached to this First Amendment (“Expansion
Premises”). 
 NOW, THEREFORE, in consideration of the foregoing Recitals, which are incorporated herein by this reference,
the mutual promises and conditions contained herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant hereby agree as follows: 

 

	1.	 Expansion Premises. In addition to the Original Premises, commencing on the
Expansion Premises Commencement Date, Landlord leases to Tenant, and Tenant leases from Landlord, the Expansion Premises. 

  

	2.	 Delivery. Tenant acknowledges that the Expansion Premises are currently leased by
an existing tenant (the “Existing Tenant”) and that concurrently herewith Landlord is entering into an amendment to such Existing Tenant’s lease in order to terminate such Existing Tenant’s rights to the Expansion Premises
as of May 31, 2018. Landlord shall deliver (“Delivery” or “Deliver”) the Expansion Premises to Tenant following such Existing Tenant surrendering the Expansion Premises to Landlord. If Landlord fails to timely
Deliver the Expansion Premises as a result of any holdover by such Existing Tenant, Landlord shall not be liable to Tenant for any loss or damage resulting therefrom, and the Lease and this First Amendment shall not be void or voidable.

 The “Expansion Premises Commencement Date” shall be the date of Delivery of the Expansion Premises,
which is estimated to occur on June 1, 2018. 
 Tenant hereby agrees that: (i) Tenant shall accept the Expansion Premises in their
condition as of the Expansion Premises Commencement Date; (ii) Landlord shall have no obligation for any defects in the Expansion Premises; and (iii) Tenant’s taking possession of the Expansion Premises shall be conclusive evidence
that Tenant accepts the Expansion Premises and that the Expansion Premises were in satisfactory condition at the time possession was taken. 

Tenant agrees and acknowledges that, except as otherwise expressly set forth in this First Amendment, neither Landlord nor any agent of
Landlord has made any representation or warranty with respect to the condition of all or any portion of the Expansion Premises, and/or the suitability of the Expansion Premises for the conduct of Tenant’s business, and Tenant waives any implied
warranty that the Expansion Premises are suitable for the Permitted Use. 
  

							
		  	 	

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	3.	 Premises and Rentable Area of Premises. 

Commencing on the Expansion Premises Commencement Date, the defined terms “Premises” and “Rentable Area of
Premises” on Page 1 of the Lease shall be deleted in their entirety and replaced with the following: 
 “Premises: That
portion of the third floor of the Project, containing approximately 23,574 rentable square feet, as determined by Landlord, as shown on Exhibit A.” 

“Rentable Area of Premises: Agreed to be 23,574 sq. ft.” 

As of the Expansion Premises Commencement Date, Exhibit A to the Lease shall be amended to include the Expansion Premises as shown on
Exhibit A attached to this First Amendment. 
  

	4.	 Base Rent. 

a. Original Premises. Tenant shall continue to pay Base Rent for the Original Premises as provided for in the Lease through the
expiration of the Term, which is scheduled to expire on July 31, 2024 (the “Current Expiration Date”). 
 b.
Expansion Premises. Commencing on the Expansion Premises Commencement Date, Tenant shall (in addition to Base Rent for the Original Premises) commence paying Base Rent with respect to the Expansion Premises at a rate of $4.75 per rentable square
foot of the Expansion Premises per month. Thereafter, on each annual anniversary of the Expansion Premises Commencement Date (each, a “Expansion Premises Adjustment Date”), Base Rent payable with respect to Expansion Premises shall
be increased by multiplying the Base Rent payable with respect to the Expansion Premises immediately before such Expansion Premises Adjustment Date by 3% and adding the resulting amount to the Base Rent payable with respect to the Expansion Premises
immediately before such Expansion Premises Adjustment Date. 
 c. Additional improvement Allowance. In addition to the
Improvement Allowance (as defined in Section 6 below), Landlord shall, subject to the terms of Section 6, make available to Tenant the Additional Improvement Allowance (as defined in
Section 6). Commencing on the Expansion Premises Commencement Date and continuing thereafter on the first day of each month during the remainder of the Base Term, Tenant shall pay the amount necessary to fully amortize the portion of the
Additional Improvement Allowance actually funded by Landlord, if any, in equal monthly payments with interest at a rate of 8% per annum over the period from the Expansion Premises Commencement Date through the Current Expiration Date, which interest
shall begin to accrue on the date that Landlord first disburses such Additional Improvement Allowance or any portion(s) thereof; provided, however, that Tenant may prepay such amount at any time without penalty. Any of the Additional Improvement
Allowance and applicable interest remaining unpaid as of the expiration or earlier termination of the Lease shall be paid to Landlord in a lump sum at the expiration or earlier termination of this Lease. 

 

	5.	 Tenant’s Share of Operating Expenses. Commencing on the Expansion Premises
Commencement Date, the defined term “Tenant’s Share of Operating Expenses” on Page 1 of the Lease shall be deleted in its entirety and replaced with the following: 

“Tenant’s Share of Operating Expenses: 17.25%” 
  

	6.	 TI Allowance. Landlord shall make available to Tenant (i) a tenant improvement
allowance in the amount of $183,500 (which is equal to $25 per rentable square foot in the Expansion Premises) (the “Improvement Allowance”) and (ii) an additional tenant improvement allowance in the 

 

							
		  	 	

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maximum amount of $183,500 (which is equal to $25 per rentable square foot in the Expansion Premises) (the “Additional Improvement Allowance”), which shall, to the extent such
Additional Improvement Allowance is used, result in an additional rental payment by Tenant in order to amortize such Additional Improvement Allowance as set forth in Section 4(c) of this First Amendment. The Improvement
Allowance and Additional Improvement Allowance is collectively referred to herein as the “Expansion Allowances.” The Expansion Allowance shall be used solely for the hard and soft costs of fixed and permanent improvements desired by
and performed by or on behalf of Tenant and reasonably acceptable to Landlord in the Original Premises and/or Expansion Premises (the “First Amendment Improvements”), which First Amendment Improvements shall be constructed pursuant
to a scope of work reasonably acceptable to Landlord and Tenant. Before commencing the First Amendment Improvements and in any event no later than the date that is 30 days following the Expansion Premises Commencement Date, Tenant shall notify
Landlord how much Additional Improvement Allowance Tenant has elected to receive from Landlord. Such election shall be final and binding on Tenant, and may not thereafter be modified without Landlord’s consent, which may be granted or withheld
in Landlord’s sole and absolute subjective discretion. The Expansion Allowances shall be disbursed in accordance with this Section 6. 

The Expansion Allowances shall be available only for the hard and soft costs of the First Amendment Improvements. Unless otherwise instructed
in writing by Landlord in its sole discretion, at the time of its approval of the First Amendment Improvements, Tenant acknowledges that upon the expiration of the Term of the Lease (as amended by this First Amendment), the First Amendment
Improvements shall become the property of Landlord and may not be removed by Tenant. Except for the Expansion Allowances, Tenant shall be solely responsible for all of the costs of the First Amendment Improvements. The First Amendment Improvements
shall be treated as Alterations and shall be undertaken pursuant to Section 12 of the Lease; provided, however, (i) with respect to the First Amendment Improvements, Landlord shall not be entitled to any management or supervision
fee (except as set forth in this Section 6), (ii) Tenant shall not be required to post any security or bond in connection with the First Amendment Improvements, and (iii) at the expiration or earlier termination of the Lease, Tenant
shall not be required to remove or restore any of the First Amendment Improvements shown in the space plan attached hereto as Exhibit B. The contractor for the First Amendment Improvements shall be selected by Tenant, subject to
Landlord’s approval, which approval shall not be unreasonably withheld, conditioned or delayed. Prior to the commencement of the First Amendment Improvements, Tenant shall deliver to Landlord a copy of any contract with Tenant’s
contractors, and certificates of insurance from any contractor performing any part of the First Amendment Improvements evidencing industry standard commercial general liability, automotive liability, “builder’s risk”, and
workers’ compensation insurance. Tenant shall cause the general contractor to provide a certificate of insurance naming Landlord, Alexandria Real Estate Equities, Inc., and Landlord’s lender (if any) as additional insureds for the general
contractor’s liability coverages required above. 
 During the course of design and construction of the First Amendment Improvements,
Landlord shall reimburse Tenant from the Expansion Allowances for the hard and soft costs of the First Amendment Improvements once a month against a draw request in Landlord’s standard form, containing evidence of payment of such hard and soft
costs of the First Amendment Improvements by Tenant and such certifications, lien waivers (including a conditional lien release for each progress payment and unconditional lien releases for the prior month’s progress payments), inspection
reports and other matters as Landlord customarily obtains, to the extent of Landlord’s approval thereof for payment, no later than 30 days following receipt of such draw request. Upon completion of the First Amendment Improvements (and prior to
any final disbursement of the Expansion Allowances), Tenant shall deliver to Landlord: (i) sworn statements setting forth the names of all contractors and first tier subcontractors who did the work and final, unconditional lien waivers from all
such contractors and first tier subcontractors; (ii) as-built plans (one copy in print format and two copies in electronic CAD format) for such First 

 

							
		  	 	

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Amendment Improvements; (iii) a certification of substantial completion in Form AIA G704, (iv) a certificate of occupancy for the Expansion Premises; and (v) copies of all
operation and maintenance manuals and warranties affecting the Expansion Premises. Notwithstanding the foregoing, if the cost of the First Amendment Improvements exceeds the Improvement Allowance plus any portion of the Additional Improvement
Allowance timely elected to be utilized by Tenant, then the Landlord’s monthly progress payments shall be made on a pari passu basis with Tenant being obligated to pay its portion of the each monthly progress payment and provide evidence to
Landlord of such progress payment. 
 The Improvement Allowance and Additional Improvement Allowance shall only be available for use by
Tenant for the hard and soft costs of the First Amendment Improvements from the date of this First Amendment through the date that is 12 months after the Expansion Premises Commencement Date (the “Outside Improvement Allowance
Date”). Any portion of the improvement Allowance and/or Additional Improvement Allowance which has not been properly requested by Tenant from Landlord on or before the Outside Improvement Allowance Date shall be forfeited and shall not be
available for use by Tenant. Tenant shall pay to Landlord administrative rent (“Administrative Rent”) equal to 1% of the hard and soft construction costs relating to the First Amendment Improvements; provided, however, at
Tenant’s written election, it may request for the Administrative Rent to be paid out of the Expansion Allowances. 
 Notwithstanding the
foregoing to the contrary, Tenant, at its election, may request Landlord to manage construction of the First Amendment Improvements. In the event Landlord, in its sole discretion, agrees to management construction of the First Amendment
Improvements, then (i) Landlord and Tenant shall enter into a lease amendment on terms mutually acceptable to Landlord and Tenant in order to document the Landlord managing the construction of the First Amendment Improvements and (ii) the
Administrative Rent payable to Landlord in such instance shall be increased to be 3% of the hard and soft construction costs relating to the First Amendment Improvements. 
  

	7.	 Security Deposit. The defined term “Security Deposit” on Page 1 of the
Lease shall be deleted in its entirety and replaced with the following: 

 “Security Deposit: $106,294.60”

 Landlord currently holds a Security Deposit of $71,429.60 under the Lease. Concurrently with Tenant’s delivery of a signed original
of this First Amendment to Landlord, Tenant shall deliver to Landlord an amended Letter of Credit which increases the amount of the existing Letter of Credit being held by Landlord to $106,294.60 or an additional Letter of Credit in the amount of
$34,865.00. 
  

	8.	 Right to Extend Term. In the event Tenant elects to exercise its option to extend the Term
for the Extension Term pursuant to Section 39 of the Lease, Tenant shall be required to extend the Term with respect to the entirety of the Premises (i.e., inclusive of both the Original Premises and the Expansion
Premises). 

  

	9.	 California Accessibility Disclosure. For purposes of Section 1938(a) of the
California Civil Code, Landlord hereby discloses to Tenant, and Tenant hereby acknowledges, that the Project has not undergone inspection by a Certified Access Specialist (CASp). In addition, the following notice is hereby provided pursuant to
Section 1938(e) of the California Civil Code: “A Certified Access Specialist (CASp) can inspect the subject premises and determine whether the subject premises comply with all of the applicable construction-related accessibility standards
under state law. Although state law does not require a CASp inspection of the subject premises, the commercial property owner or lessor may not prohibit the lessee or tenant from obtaining a CASp inspection of the subject premises for the occupancy
or potential occupancy of the lessee or 

  

							
		  	 	

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tenant, if requested by the lessee or tenant. The parties shall mutually agree on the arrangements for the time and manner of the CASp inspection, the payment of the fee for the CASp inspection,
and the cost of making any repairs necessary to correct violations of construction-related accessibility standards within the premises.” Landlord and Tenant hereby agree as follows (which constitute the mutual agreement of the parties as to the
matters described in the last sentence of the foregoing notice): (A) Tenant shall have the one-time right to request for and obtain a CASp inspection, which request must be made, if at all, in a written notice
delivered by Tenant to Landlord; (B) any CASp inspection timely requested by Tenant shall be conducted (1) at a time mutually agreed to by Landlord and Tenant, (2) in a professional manner by a CASp designated by Landlord and without
any testing that would damage the Premises, Building or Project in any way, and (3) at Tenant’s sole cost and expense, including, without limitation, Tenant’s payment of the fee for such CASp inspection, the fee for any reports
prepared by the CASp in connection with such CASp inspection (collectively, the “CASp Reports”) and all other costs and expenses in connection therewith; (C) the CASp Reports shall be delivered by the CASp simultaneously to
Landlord and Tenant; (D) Tenant, at its sole cost and expense, shall be responsible for making any improvements, alterations, modifications and/or repairs to or within the Premises to correct violations of construction-related accessibility
standards including, without limitation, any violations disclosed by such CASp inspection; and (E) if such CASp inspection identifies any improvements, alterations, modifications and/or repairs necessary to correct violations of
construction-related accessibility standards relating to those items of the Building and Project located outside the Premises that are Landlord’s obligation to repair as set forth in the Lease, then Landlord shall perform such
improvements, alterations, modifications and/or repairs as and to the extent required by Legal Requirements to correct such violations, and Tenant shall reimburse Landlord for the cost of such improvements, alterations, modifications and/or repairs
within 10 business days after Tenant’s receipt of an invoice therefor from Landlord. 

  

	10.	 OFAC. Tenant and all beneficial owners of Tenant are currently (a) in
compliance with and shall at all times during the Term of this Lease remain in compliance with the regulations of the Office of Foreign Assets Control (“OFAC”) of the U.S. Department of Treasury and any statute, executive order, or
regulation relating thereto (collectively, the “OFAC Rules”), (b) not listed on, and shall not during the term of the Lease be listed on, the Specially Designated Nationals and Blocked Persons List, Foreign Sanctions Evaders List,
or the Sectoral Sanctions Identification List, which are all maintained by OFAC and/or on any other similar list maintained by OFAC or other governmental authority pursuant to any authorizing statute, executive order, or regulation, and (c) not
a person or entity with whom a U.S. person is prohibited from conducting business under the OFAC Rules. 

  

	11.	 Brokers. Landlord and Tenant each represents and warrants that it has not dealt
with any broker, agent or other person (collectively, “Broker”) other than Newmark Cornish & Carey, in connection with the transaction reflected in this First Amendment and that no Broker brought about this transaction,
other than Newmark Cornish & Carey. Landlord and Tenant each hereby agrees to indemnify and hold the other harmless from and against any claims by any Broker, other than Newmark Cornish & Carey, claiming a commission or other form
of compensation by virtue of having dealt with Tenant or Landlord, as applicable, with regard to this First Amendment. Landlord shall pay the Broker a commission pursuant to a separate written agreement. 

 

	12.	 Miscellaneous. 

a. This First Amendment is the entire agreement between the parties with respect to the subject matter hereof and supersedes all prior
and contemporaneous oral and written agreements and discussions. This First Amendment may be amended only by an agreement in writing, signed by the parties hereto. 
  

							
		  	 	

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 b. This First Amendment is binding upon and shall inure to the benefit of the parties
hereto and their respective successors and assigns. 
 c. This First Amendment may be executed in two (2) or more counterparts,
each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. Counterparts may be delivered via facsimile, electronic mail (including pdf or any electronic signature process complying with the
U.S. federal ESIGN Act of 2000) or other transmission method and any counterpart so delivered shall be deemed to have been duly and validly delivered and be valid and effective for all purposes. Electronic signatures shall be deemed original
signatures for purposes of this First Amendment and all matters related thereto, with such electronic signatures having the same legal effect as original signatures. 

d. Except as amended and/or modified by this First Amendment, the Lease is hereby ratified and confirmed and all other terms of the
Lease shall remain in full force and effect, unaltered and unchanged by this First Amendment. In the event of any conflict between the provisions of this First Amendment and the provisions of the Lease, the provisions of this First Amendment shall
prevail. Whether or not specifically amended by this First Amendment, all of the terms and provisions of the Lease are hereby amended to the extent necessary to give effect to the purpose and intent of this First Amendment. 

[Signatures are on the next page.] 
  

							
		  	 	

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the Alexandria Logo are registered trademarks of Alexandria Real Estate Equities, Inc.

  
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 IN WITNESS WHEREOF, the parties hereto have executed this First Amendment as of the
day and year first above written. 
  

			
	TENANT:
	
	 IDEAYA BIOSCIENCES, INC.,
 a
Delaware corporation

		
	By:	 	/s/ Yujiro Hata
	Its:	 	Yujiro Hata

  

			
	LANDLORD:
	
	 ARE-SAN FRANCISCO NO. 17, LLC,

a Delaware limited liability company

		
	By:	 	 ALEXANDRIA REAL ESTATE EQUITIES, L.P.,

a Delaware limited partnership,
 managing member

  

					
		 	By:	 	 ARE-QRS CORP.,

a Maryland corporation,
 general partner

  

							
		 		 	By:	 	/s/ Eric S. Johnson
		 		 	Its:	 	Eric S. Johnson
		 		 		 	 Senior Vice President
 RE Legal
Affairs

  
  

							
		  	 	

	 	  	Copyright © 2005, Alexandria Real Estate Equities, Inc. ALL RIGHTS RESERVED. Confidential and Proprietary – Do Not Copy or Distribute. Alexandria and
the Alexandria Logo are registered trademarks of Alexandria Real Estate Equities, Inc.

  
 7 

 EXHIBIT A  

Expansion Premises 
  

 
 

 
 . 
  

							
		  	 	

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the Alexandria Logo are registered trademarks of Alexandria Real Estate Equities, Inc.

  
 1 

 EXHIBIT B 

Description of First Amendment Improvements 
  

 
 

 
  

							
		  	 	

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 1 

 

 
  

							
		  	 	

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