Document:

Loan Agreement

 Exhibit 10.1 
 LOAN AGREEMENT 
 by and between 
 GTC Biotherapeutics, Inc. 
 and 
 LFB Biotechnologies S.A.S. 
 June 18, 2009 

 LOAN AGREEMENT 
 This Loan Agreement (this “Agreement”) dated as of June 18, 2009 is made by and between GTC Biotherapeutics, Inc., a Massachusetts corporation, (the “Borrower”), and LFB
Biotechnologies, S.A.S., a société par actions simplifiée established under the laws of France (the “Lender”). 
 RECITALS 
 WHEREAS, the Borrower has requested that the Lender provide certain financing facilities for the purposes
of repaying in full the outstanding indebtedness of the Borrower to General Electric Capital Corporation and financing the development of the Borrower’s clinical and pre-clinical programs and the Lender is willing to do so on the terms and
conditions set forth herein. 
 NOW THEREFORE, in consideration of the promises and the mutual covenants contained herein and other good and
valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Borrower and the Lender hereby agree as follows: 
  

	 	1.	CREDIT FACILITIES 

 (a) Term Loan.
Subject to the terms and conditions contained herein, the Lender hereby agrees to make a term loan in the original principal amount of $3,500,000 (the “Term Loan”) to the Borrower on the Closing Date (as defined in Section 3
below). The Term Loan shall be evidenced by a promissory note of the Borrower, payable to the order of the Lender, in the original principal amount of $3,500,000, which note shall be in substantially the form attached hereto as Exhibit A (the
“Secured Note”). The Borrower hereby irrevocably authorizes the Lender to make or cause to be made, on a schedule attached to the Secured Note or on the books of the Lender, at or following the time of receiving each payment of
principal of the Secured Note, an appropriate notation reflecting such transaction and the then aggregate unpaid principal balance of the Term Loan. The aggregate unpaid principal amount of the Term Loan, as recorded by the Lender from time to time
on such schedule or on such books, shall constitute presumptive evidence of such amount. Failure of the Lender to make any such notation shall not, however, affect any obligation of the Borrower hereunder or under the Secured Note. 
 (b) Repayment Terms; Interest Rate. The principal amount of the Term Loan shall be paid in the amounts and on the dates specified
in the Secured Note. The Borrower further agrees to pay interest in like money on the unpaid principal amount of the Term Loan from time to time outstanding at the rates and on the dates specified in the Secured Note. The Borrower may at its option
prepay at any time, without premium or penalty, the whole or any portion of the Term Loan, provided that each such prepayment shall be accompanied by payment of all interest on the prepaid portion of such Term Loan accrued to the date of such
prepayment. Any partial prepayment of principal of the Term Loan will be applied to installments of principal of the Term Loan (including without limitation, the final “balloon” payment) thereafter coming due in inverse order of normal
maturity. Amounts paid or prepaid with respect to the Term Loan are not available for reborrowing. 

 (c) Note Purchase. Subject to the terms and conditions contained herein and in
that certain Securities Purchase Agreement by and between the Borrower and the Lender dated as of the date hereof (the “Purchase Agreement”), the Borrower shall issue to the Lender on the Closing Date, and the Lender shall accept
from the Borrower, a convertible secured note of the Borrower in the original principal amount of $4,512,268, which note shall be in substantially the form attached hereto as Exhibit B (the “2009 Convertible Note”). Subject
to the automatic conversion into shares of the Borrower’s Series E-1 10% Convertible Preferred Stock upon the approval of the Borrower’s shareholders pursuant to the terms of the 2009 Convertible Note and the Purchase Agreement, principal
and interest on the 2009 Convertible Note shall be paid in the amounts, at the rates and on the dates specified in the 2009 Convertible Note. The 2009 Convertible Note shall not be prepaid except with the written consent of the Lender. The Borrower
and Lender hereby acknowledge that a portion of the 2009 Convertible Note in the principal amount of $512,268 represents a portion of the Borrower’s share of common program expenses for 2008 under that certain Amended and Restated Joint
Development and Commercialization Agreement dated June 30, 2008, has been funded to the Borrower prior to the date hereof, and is excluded from the purchase price of the 2009 Convertible Note. 
  

	 	2.	CONDITIONS OF LENDING 

 (a) Conditions Precedent.
Prior to the making of the Term Loan hereunder and the purchase by the Lender of the 2009 Convertible Note, the Borrower shall deliver to the Lender duly executed copies of this Agreement, and shall deliver to the Lender the documents enumerated
below in this Section 2(a), all of which, shall be satisfactory in form and substance to the Lender and its counsel, or shall otherwise shall be waived by the Lender in the exercise of its sole discretion: 
 (i) That certain Amended and Restated Security Agreement from the Borrower to the Lender, which shall be in substantially the form
attached hereto as Exhibit C (the “Security Agreement”), duly executed by the Borrower. 
 (ii) The
Secured Note and the 2009 Convertible Note, each duly executed by the Borrower. 
 (iii) That certain Amendment to Mortgage,
Security Agreement and Fixture Filing from the Borrower to the Lender, which shall be in substantially the form attached hereto as Exhibit D (the “Mortgage Amendment”), duly executed by the Borrower. 
 (iv) The Purchase Agreement, which shall be substantially in the form attached hereto as Exhibit E, duly executed by the Borrower.

 (v) Certified copies of the resolutions of the Board of Directors of the Borrower evidencing approval of this Agreement,
the Secured Note, the 2009 Convertible Note, the Security Agreement, the Mortgage Amendment and the other matters contemplated hereby and thereby. 
  

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 (vi) A certificate, signed by the clerk of the Borrower, setting forth the names and
titles of the officers of the Borrower authorized to sign this Agreement, the Secured Note, the 2009 Convertible Note, the Security Agreement, the Mortgage Amendment and any and all other agreements, certificates, notices and reports referred to
herein; such certificate shall contain the true signatures of such officers. 
 (vii) A copy of the restated certificate of
organization of the Borrower and all amendments thereto, certified by the secretary of the Commonwealth of Massachusetts, the jurisdiction of organization of the Borrower; a copy of the by-laws of the Borrower, as amended to date, as certified by
its clerk; and a certificate of good standing for the Borrower in its jurisdiction of organization. 
 (viii) A favorable
written opinion of counsel to the Borrower, in form and substance reasonably satisfactory to the Lender. 
 (ix) Except as
expressly set forth in Section 2(b) below, such documents as shall be reasonably necessary to vest in the Lender a first priority security interest in and to (subject to Permitted Liens as such term is defined in the Security Agreement) all of
the Collateral (as such term is defined in the Security Agreement), and evidence of all filings, recordations and other actions reasonably necessary to perfect fully the Lender’s security interests. 
 (x) A date-down title endorsement in form and substance reasonably satisfactory to the Lender to the Loan Policy of Title Insurance issued
by Old Republic National Title Insurance Company in favor of the Lender. 
 (xi) Evidence that the loans, other obligations
and any indebtedness whatsoever of the Borrower to General Electric Capital Corporation (“GECC”) have been repaid or will be repaid with the Term Loan made hereunder on the Closing Date and the commitments thereunder have been
terminated and that the Subordination and Intercreditor Agreement among the Borrower the Lender and GECC, and all mortgages, financing statements, and liens associated therewith have been released or otherwise terminated. 
 (xii) Certificates of insurance in form and substance reasonably satisfactory to the Lender evidencing the insurance coverage required to
be maintained pursuant to the Security Agreement and that the Lender has been named as additional insured or loss payee thereunder 
 (xiii) Control agreements in form and substance substantially similar to those delivered to GECC or otherwise reasonably satisfactory to the Lender, with respect to each securities, depository or disbursement account of the Borrower (other
than any tax or payroll account), each duly executed by the Borrower and the applicable depository institution. 
 (xiv) Such
other documents, instruments, records, assignments, consents, certificates, opinions, assurances and authorizations as the Lender shall reasonably require. 
  

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 (b) Conditions Subsequent. The Borrower agrees to take the actions, and to deliver to the Lender,
in form and substance substantially similar to those delivered to GECC, the items set forth below on or before the dates set forth below: 
 (i) Within 30 days after the Closing Date, (i) deliver to the Lender a Pledge Agreement, duly executed by the Borrower, pursuant to which the Borrower pledges not in excess of 65% of the equity interests held by
it in GTC Holding, Ltd. and an opinion of local counsel, each in form and substance reasonably satisfactory to the Lender, and (ii) take any other steps reasonably necessary, under the law of all applicable jurisdictions, to cause such pledge
to be properly perfected as a first priority security interest. 
 (ii) Within 30 days after the Closing Date, use best
efforts to cause each of Lonza Biologics, Inc., Cryonix, Inc. and Biomedical Research Models, Inc. to enter into a bailee acknowledgement with Lender. 
 (iii) Within 45 days after the Closing Date, use best efforts to cause MedImmune, Inc. to enter into a bailee acknowledgement with Lender. 
 (iv) Within 30 days after the Closing Date, Borrower shall use its commercially reasonable efforts to deliver, or cause to be delivered,
to Lender a lien waiver and collateral access agreement, in form and substance reasonably satisfactory to the Lender for each of the following leased real property locations: 
  

	 	a.	175 Crossing Blvd., Framingham, MA 01702; and 

  

	 	b.	5 Mountain Road, Framingham, MA 01702. 

 (v) Within 45 days after the Closing Date, Borrower shall use its best efforts to provide its and/or the Lender’s foreign correspondents with the information and documentation reasonably necessary to cause the Lender’s security
interest in certain of the Borrower’s Intellectual Property held outside of the United States of America and set forth on Schedule 2(b) hereto to be properly perfected as a first priority lien as promptly as possible. 
  

	 	3.	CLOSING 

 Upon the satisfaction of the conditions set forth
in Section 2(a) above, on a business day as may be mutually agreed by the Lender and the Borrower (the “Closing Date”), the Lender shall fund the Term Loan and $4,000,000 (representing the purchase price of the 2009 Convertible
Note) to the Borrower by wire transfer of immediately available funds in accordance with written wire instructions provided to the Lender. 
  

	 	4.	MISCELLANEOUS 

 (a) Governing Law. All questions
concerning the construction, validity, enforcement and interpretation of this Agreement shall be governed by the internal laws of the Commonwealth of Massachusetts, United States of America, without giving effect to any choice of law or conflict of
law provision or rule (whether of the Commonwealth of Massachusetts or any other jurisdictions) that would cause the application of the laws of any jurisdictions other 

  

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than the Commonwealth of Massachusetts. If any provision of this Agreement shall be invalid or unenforceable in any jurisdiction, such invalidity or
unenforceability shall not affect the validity or enforceability of the remainder of this Agreement in that jurisdiction or the validity or enforceability of any provision of this Agreement in any other jurisdiction. 
 (b) Entire Agreement. This Agreement and the documents referenced herein and therein constitute the entire agreement among the parties hereto with
respect to the subject matter hereof and thereof. There are no restrictions, promises, warranties or undertakings, other than those set forth or referred to herein and therein. This Agreement and the documents referenced herein and therein supersede
all prior agreements and understandings among the parties hereto with respect to the subject matter hereof and thereof. 
 (c) Amendments
and Waivers. No provision of this Agreement may be amended or waived other than by an instrument in writing signed by the Borrower and by the Lender. 
 (d) Notices. Any notices, consents, waivers or other communications required or permitted to be given under the terms of this Agreement must be in writing and will be deemed to have been delivered:
(i) upon receipt, when delivered personally; (ii) upon receipt, when sent by facsimile (provided confirmation of transmission is mechanically or electronically generated and kept on file by the sending party); or (iii) upon receipt,
when sent via a nationally recognized overnight delivery service, in each case properly addressed to the party to receive the same. The addresses and facsimile numbers for such communications shall be: 
  

							
	If to the Borrower:	 	
		
		 	 GTC Biotherapeutics, Inc.
 175 Crossing
Boulevard
 Suite 410
 Framingham, MA 01702

		 	Telephone:	 	(508) 370-2061
		 	Facsimile:	 	(508) 271-3491
		 	Attention:	 	Geoffrey F. Cox, Ph.D.
		 	Chairman, President and Chief Executive Officer
		
	with a copy to:	 	
		
		 	 Edwards Angell Palmer & Dodge LLP
 111
Huntington Avenue
 Boston, MA 02199

		 	Tel:	 	(617) 239-0100
		 	Fax:	 	(617) 227-4420
		 	Attn:	 	Nathaniel S. Gardiner, Esq.
				
	If to the Lender:	 		 		 	
		
		 	 LFB-Biotechnologies S.A.S.
 3, avenue des
Tropiques
 LES ULIS

  

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		 	91940 Courtaboeuf - France
		 	Tel:	 	+33 (0) 1 69 82 70 10
		 	Fax:	 	+33 (0) 1 6982 72 67
		 	Attn:	 	M. Christian Bechon, President
				
	with a copy to:	 		 		 	
		
		 	 Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
 One Financial Center
 Boston, MA 02111

		 	Tel:	 	(617) 542-6000
		 	Fax:	 	(617) 542-2241
		 	Attn: Brian P. Keane, Esq.

 (e) No Strict Construction. The language used in this Agreement will be deemed to be the
language chosen by the parties to express their mutual intent, and no rules of strict construction will be applied against any party. 
 (f)
Further Assurances. Each party shall do and perform, or cause to be done and performed, all such further acts and things, and shall execute and deliver all such other agreements, certificates, instruments and documents, as the other party may
reasonably request in order to carry out the intent and accomplish the purposes of this Agreement and the consummation of the transactions contemplated hereby. 
 (g) Severability. If any provision of this Agreement shall be invalid or unenforceable in any jurisdiction, such invalidity or unenforceability shall not affect the validity or enforceability of the remainder
of this Agreement in that jurisdiction or the validity or enforceability of any provision of this Agreement in any other jurisdiction. 
 (h)
Successors and Assigns. This Agreement shall be binding upon and inure to the benefit of the parties and their respective successors and assigns. 
 (i) Headings. The headings of this Agreement are for convenience of reference only and shall not limit or otherwise affect the meaning hereof. 
 (j) Counterparts. This Agreement may be executed in identical counterparts, each of which shall be deemed an original but all of which shall
constitute one and the same agreement. This Agreement, once executed by a party, may be delivered to the other party hereto by facsimile transmission of a copy of this Agreement bearing the signature of the party so delivering this Agreement.

 (k) WAIVER OF JURY TRIAL. BORROWER AND LENDER UNCONDITIONALLY WAIVE THEIR RIGHTS TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION
BASED UPON OR ARISING OUT OF THIS AGREEMENT, ANY OF THE OTHER DOCUMENTS EXECUTED IN CONNECTION HEREWITH, ANY OF THE INDEBTEDNESS SECURED HEREBY OR THEREBY, ANY DEALINGS BETWEEN BORROWER AND LENDER RELATING TO THE SUBJECT MATTER OF THIS 

  

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TRANSACTION OR ANY RELATED TRANSACTIONS, AND/OR THE RELATIONSHIP BETWEEN LENDER AND BORROWER. THE SCOPE OF THIS WAIVER IS INTENDED TO BE ALL ENCOMPASSING OF
ANY AND ALL DISPUTES THAT MAY BE FILED IN ANY COURT. THIS WAIVER IS IRREVOCABLE. THIS WAIVER MAY NOT BE MODIFIED EITHER ORALLY OR IN WRITING. THE WAIVER ALSO SHALL APPLY TO ANY SUBSEQUENT AMENDMENTS, RENEWALS, SUPPLEMENTS OR MODIFICATIONS TO THIS
AGREEMENT, ANY OTHER DOCUMENTS EXECUTED IN CONNECTION HEREWITH, OR TO ANY OTHER DOCUMENTS OR AGREEMENTS RELATING TO THIS TRANSACTION OR ANY RELATED TRANSACTION. THIS AGREEMENT MAY BE FILED AS A WRITTEN CONSENT TO A TRIAL BY THE COURT. 
 [Remainder of page intentionally left blank. 
 Signature page to follow.] 
  

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 IN WITNESS WHEREOF, the parties have caused this Loan Agreement to be duly executed as of the date first
written above. 
  

			
	BORROWER:
	
	GTC BIOTHERAPEUTICS, INC.
		
	By:	 	 /s/ John B. Green

		 	John B. Green
		 	Senior Vice President, Chief Financial Officer and Treasurer
	
	LENDER:
	
	LFB BIOTECHNOLOGIES S.A.S.
		
	By:	 	 /s/ Max Berger

		 	Max Berger, Director of Legal Affairs, for and on behalf of Christian Bechon, President Directeur General, by Power of Attorney dated June 18, 2009

 [Signature Page to Loan Agreement] 

 Exhibit A 
 Form of Secured Note 

 Exhibit B 
 Form of 2009 Convertible Note 

 Exhibit C 
 Form of Amended and Restated Security Agreement 

 Exhibit D 
 Form of Amendment to Mortgage, Security Agreement and Fixture Filing 

 Exhibit E 
 Form of Purchase Agreement 

 Schedule 2(b) 
 Foreign Intellectual Property to be PerfectedAmended and Restated Security Agreement

 Exhibit 10.2 
 AMENDED AND RESTATED SECURITY AGREEMENT 
 THIS AMENDED AND RESTATED SECURITY AGREEMENT (this
“Agreement”) dated as of the 18th day of June, 2009 and effective as of December 22, 2008 with respect to the below-defined 2008 Convertible Note, the below-defined 2008 Purchase Agreement and all obligations related thereto,
from GTC BIOTHERAPEUTICS, INC. (“Debtor”) in favor of LFB BIOTECHNOLOGIES S.A.S. (together with its successors and assigns, if any, “Secured Party”). Secured Party has an office at 3, avenue des
Tropiques, Les Ulis, Courtaboeuf, France. Debtor is a corporation organized and existing under the laws of the Commonwealth of Massachusetts (the “State”). Debtor’s mailing address and chief place of business is 175 Crossing
Blvd., Framingham, MA 01702. 
 RECITALS: 
 WHEREAS, the Debtor issued and sold to the Secured Party a subordinated convertible note dated as of December 14, 2006 in the original principal amount of $2,558,650 (the “2006 Convertible
Note”). 
 WHEREAS, pursuant to that certain Note and Warrant Purchase Agreement by and between the Debtor and the Secured
Party dated as of October 31, 2008 (the “2008 Purchase Agreement”), the Debtor issued and sold to the Secured Party a secured convertible note dated as of December 22, 2008 in the original principal amount of $15,000,000
(the “2008 Convertible Note”) and that certain Warrant dated as of December 22, 2008 (the “Warrant”) to purchase up to 23,193,548 shares of common stock of the Debtor. 
 WHEREAS, it was a condition to the 2008 Purchase Agreement that the Debtor execute and deliver the Security Agreement dated as of
December 22, 2008 from Debtor in favor of Secured Party (the “Original Security Agreement”), pursuant to which the obligations of the Debtor to the Secured Party under the 2008 Purchase Agreement and the 2008 Convertible Note
were secured. 
 WHEREAS, subject to the terms and conditions of that certain Securities Purchase Agreement dated as of the date
hereof by and between the Debtor and the Secured Party (the “2009 Purchase Agreement”), the Debtor intends to issue and sell to the Secured Party a secured convertible note dated as of the date hereof in the original principal
amount of $4,512,268 (the “2009 Convertible Note”). 
 WHEREAS, pursuant to that certain Loan Agreement dated as of
the date hereof between the Debtor and Secured Party and subject to the satisfaction of the conditions contained therein, the Secured Party has committed to make a term loan to the Debtor in the aggregate principal amount of $3,500,000 and in
connection therewith the Debtor is issuing to the Secured Party a promissory note dated as of the date hereof in the original principal amount of $3,500,000 (the “Secured Note”, and together with the 2006 

  

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Convertible Note, the 2008 Convertible Note and the 2009 Convertible Note, collectively, the “Notes”). 
 WHEREAS, in connection with the issuance of the Secured Note and the 2009 Convertible Note, the Debtor is amending and restating the Original
Security Agreement in its entirety and delivering this Agreement in favor of Secured Party, pursuant to which all debts, obligations and liabilities of the Debtor to the Secured Party are secured, including without limitation, the obligations under
the 2008 Purchase Agreement, the 2009 Purchase Agreement, the Loan Agreement, the 2006 Convertible Note, the 2008 Convertible Note, the 2009 Convertible Note and the Secured Note. 
 NOW, THEREFORE, in consideration of the mutual covenants and undertakings herein contained, Debtor and Secured Party agree as follows: 

 

	1.	CREATION OF SECURITY INTEREST. 

 Debtor grants to
Secured Party, its successors and assigns, a continuing security interest in, to and against all property listed on any collateral schedule now or in the future annexed to or made a part of this Agreement (“Collateral Schedule”),
including without limitation the property listed on Collateral Schedule No. 1, whether now owned or existing or hereafter acquired or arising and wheresoever located, and in and against all additions, attachments, accessories and accessions to
such property, all substitutions, replacements or exchanges therefor, and all proceeds or products thereof, in whatever form, including without limitation cash, deposit accounts (whether or not comprised solely of proceeds), certificates of deposit,
insurance proceeds (including hazard, flood and credit insurance), negotiable instruments for the payment of money, chattel paper, security agreements, documents, eminent domain proceeds, condemnation proceeds and/or tort claim proceeds (all such
property is individually and collectively called the “Collateral”). This security interest is given to secure the payment and performance of all debts, obligations and liabilities of any kind whatsoever (including all interest
(whether or not allowed or disallowed), charges, expenses, fees and other sums accruing after commencement of any case, proceeding or other action relating to the bankruptcy, insolvency or reorganization of Debtor) of Debtor to Secured Party, now
existing or arising in the future, including without limitation, the debts, obligations and liabilities of Debtor to Secured Party in connection with the payment and performance of the 2006 Convertible Note, the 2008 Convertible Note, the 2009
Convertible Note, the Secured Note, the 2008 Purchase Agreement (excluding the Warrant), the 2009 Purchase Agreement, the Loan Agreement, that certain Trademark and License Security Agreement by and between the Debtor and the Secured Party dated as
of December 22, 2008 (the “Trademark Security Agreement”), that certain Patent and License Security Agreement by and between the Debtor and the Secured Party dated as of December 22, 2008 (the “Patent Security
Agreement”), and that certain Second Mortgage, Security Agreement and Fixture Filing dated December 22, 2008 granted by Debtor to Secured Party, as amended by that certain Amendment to Mortgage, Security Agreement and Fixture Filing
dated as of the date hereof (as so amended, the “Mortgage”), together with all Schedules and attachments thereto and any renewals, extensions, modifications, amendments and/or restatements of any such debts, obligations and
liabilities (such 

  

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Notes, the 2008 Purchase Agreement, the 2009 Purchase Agreement, Loan Agreement, Trademark Security Agreement, Patent Security Agreement, Mortgage,
Schedules, debts, obligations and liabilities are called the “Indebtedness”). 
  

	2.	REPRESENTATIONS, WARRANTIES AND COVENANTS OF DEBTOR. 

 Debtor represents, warrants and covenants as of the date of this Agreement and as of the date of each Collateral Schedule that: 
 (a) Debtor’s exact legal name is as set forth in the preamble of this Agreement and Debtor is, and will remain, duly organized, existing and in good standing under the laws of the State set forth in the preamble of this Agreement, has
its chief executive offices at the location specified in the preamble, and is, and will remain, duly qualified and licensed in every jurisdiction wherever necessary to carry on its business and operations. As of the date hereof, GTC Holding Ltd., an
exempted company incorporated with limited liability under the laws of the Cayman Islands, is the only Subsidiary of the Debtor that is a “significant subsidiary” as determined in accordance with Regulation S-X; 
 (b) Debtor has adequate power and capacity to enter into, and to perform its obligations under this Agreement, each Note, the Patent Security Agreement,
the Trademark Security Agreement, the Mortgage, the Warrant, the Loan Agreement, and any other documents evidencing, or given in connection with, any of the Indebtedness (all of the foregoing are called the “Debt Documents”);

 (c) This Agreement and the other Debt Documents have been duly authorized, executed and delivered by Debtor and constitute legal, valid
and binding agreements enforceable in accordance with their terms, except to the extent that the enforcement of remedies may be limited under applicable bankruptcy and insolvency laws and general principles of equity; 
 (d) No approval, consent or withholding of objections is required from any governmental authority or instrumentality with respect to the entry into, or
performance by Debtor of any of the Debt Documents, except any already obtained; 
 (e) The entry into, and performance by, Debtor of the
Debt Documents will not (i) violate any of the organizational documents of Debtor or any judgment, order, law or regulation applicable to Debtor or (ii) result in any breach of or constitute a default under any contract or agreement to
which Debtor is a party, or result in the creation any lien, claim or encumbrance on any of Debtor’s property (except for liens in favor of Secured Party) pursuant to any indenture, mortgage, deed of trust, bank loan, credit agreement or other
agreement or instrument to which Debtor is a party; 
 (f) Except as set forth on Schedule 2(f) attached hereto, there are no suits or
proceedings pending in court or before any commission, board or other administrative agency against or affecting Debtor which could, in the aggregate, have a material adverse effect on Debtor, its business or operations, or its ability to perform
its obligations under 

  

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the Debt Documents, nor does Debtor have reason to believe that any such suits or proceedings are threatened; 
 (g) All financial statements delivered to Secured Party in connection with the Indebtedness have been prepared in accordance with generally accepted
accounting principles, except that quarterly financial statements will not provide footnotes and will be subject to normal year-end adjustments, and since the date of the most recent financial statement, except as disclosed in the Debtor’s most
recently filed periodic report with the Securities and Exchange Commission (“SEC”), there has been no material adverse change in Debtor’s financial condition; 
 (h) The Collateral is not, and will not be, used by Debtor for personal, family or household purposes; 
 (i) The Collateral is, and will remain, in good condition and repair (ordinary wear and tear excepted), and Debtor will not be negligent in its care and
use; 
 (j) Debtor is, and will remain, the sole and lawful owner, and in possession of (other than the Offsite Collateral (defined below)
(solely with respect to possession)), the Collateral, and has the sole right and lawful authority to grant the security interest described in this Agreement; 
 (k) The Collateral is, and will remain, free and clear of all liens, claims and encumbrances of any kind whatsoever, except for (i) liens in favor of Secured Party, (ii) liens existing as of the date of this
Agreement and set forth on Schedule 2(k) attached hereto, (iii) liens for taxes not yet due or for taxes being contested in good faith and which do not involve, in the judgment of Secured Party, any risk of the sale, forfeiture or loss
of any of the Collateral and with respect to which adequate reserves have been set aside for the payment thereof in accordance with GAAP, (iv) liens relating to purchase money financings that have been entered into in the ordinary course of
business, and (v) inchoate materialmen’s, mechanic’s, repairmen’s and similar liens arising by operation of law in the normal course of business for amounts which are not delinquent (all of such liens are called
“Permitted Liens”); 
 (l) Debtor is and will remain in full compliance with all laws and regulations applicable to it
including without limitation (i) ensuring that no person who owns a controlling interest in or otherwise controls Debtor is or shall be (A) listed on the Specially Designated Nationals and Blocked Person List maintained by the Office of
Foreign Assets Control (“OFAC”), Department of the Treasury, and/or any other similar lists maintained by OFAC pursuant to any authorizing statute, Executive Order or regulation or (B) a person designated under
Section 1(b), (c) or (d) of Executive Order No. 13224 (September 23, 2001), any related enabling legislation or any other similar Executive Orders, and (ii) compliance with all applicable Bank Secrecy Act
(“BSA”) laws, regulations and government guidance on BSA compliance and on the prevention and detection of money laundering violations; 
  

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 (m) Debtor’s and each Subsidiary’s (defined below) Intellectual Property (as defined in
Section 7 below) is and will remain free and clear of all liens, claims and encumbrances of any kind whatsoever, except for Permitted Liens as defined in subsection (k) of this Section, the granting of licenses of Debtor’s
Intellectual Property in the ordinary course of business and other licensing, partnership or joint ventures entered into in the ordinary course of Debtor’s business and permitted hereunder. For purposes of this Agreement, the term
“Subsidiary” shall mean a corporation or other entity of which more than 50% of the outstanding stock or other ownership interests having ordinary voting power to elect a majority of the directors (or other persons performing
similar functions) of such corporation is owned, directly or indirectly, by Debtor; 
 (n) Debtor has not and will not, and will not permit
any Subsidiary to, enter into any other agreement or financing arrangement in which it grants a negative pledge in Debtor’s or any Subsidiary’s Intellectual Property to any other party; 
 (o) Debtor agrees that it shall not, and shall not allow any of its Subsidiaries to, directly or indirectly, create, incur, assume, permit to exist,
guarantee or otherwise become or remain directly or indirectly liable with respect to, any Debt (as hereinafter defined), except for (i) Debt of Debtor to Secured Party, (ii) Debt existing on the date hereof and set forth on Schedule
2(o) to this Agreement, (iii) Debt (a) secured by a Lien described in Section 2(k)(iv) hereof, (b) related to unsecured letter of credit obligations incurred by Debtor in the ordinary course of its business and
(c) unsecured obligations to trade creditors incurred in the ordinary course of business and more than ninety (90) days past due, provided, that the amount of such additional Debt permitted by (a)-(c) shall not exceed
$1,500,000 in the aggregate, and (iv) Debt pursuant to which the Debtor, the Secured Party and the holder of such debt have entered into a subordination agreement acceptable to the Secured Party, if any (“Subordinated Debt”).
The term “Debt” shall mean, with respect to any person, at any date, without duplication, (A) all obligations of such person for borrowed money, (B) all obligations of such person evidenced by bonds, debentures, notes or
other similar instruments, or upon which interest payments are customarily made, (C) all obligations of such person to pay the deferred purchase price of property or services incurred in the ordinary course of business if the purchase price is
due more than six (6) months from the date the obligation is incurred, (D) all capital lease obligations of such person, (E) the principal balance outstanding under any synthetic lease, tax retention operating lease, off-balance sheet
loan or similar off-balance sheet financing product, (F) all obligations of such person to purchase securities (or other property) which arise out of or in connection with the issuance or sale of the same or substantially similar securities (or
property), (G) all contingent or non-contingent obligations of such person to reimburse any bank or other person in respect of amounts paid under a letter of credit or similar instrument, (H) all equity securities of such person subject to
repurchase or redemption otherwise than at the sole option of such person, (I) all Indebtedness secured by a lien on any asset of such person, whether or not such Debt is otherwise an obligation of such person, (J) all obligations of such
person under any foreign exchange contract, currency swap agreement, interest rate swap, cap or collar agreement or other similar agreement or arrangement designed to alter the risks of that person arising from fluctuations in currency values or
interest rates, in each case whether contingent or matured, (K) all obligations or liabilities of others guaranteed by such 

  

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person; and (L) all obligations of such person to trade creditors (other than Genzyme Corporation) incurred in the ordinary course of business and more
than ninety (90) days past due; 
 (p) Debtor agrees that it shall not, and shall not allow any of its Subsidiaries to, (i) make
any payment in respect of any Subordinated Debt, except in accordance with any applicable Subordination Agreement or (ii) amend, supplement, modify or waive any of the terms of any document governing any Subordinated Debt. Debtor further agrees
to provide Secured Party copies of any notices, reports, financial statements, financial information or other information either delivered or received by Debtor in relation to the Subordinated Debt or pursuant to any subordinated note except to the
extent that such information is to be provided to Secured Party under this Agreement or any of the other Debt Documents; 
 (q) After the
Closing Date (as defined in the Loan Agreement), Debtor shall not and shall not allow any of its Subsidiaries to open or maintain any securities, depository or disbursement accounts except upon thirty (30) days’ prior written notice to
Secured Party, and Debtor shall not, and shall not allow any Subsidiary to, use any such accounts until such time as the applicable securities intermediary or depository institution, as the case may be, Debtor or such subsidiary of Debtor, as the
case may be, and Secured Party have entered into a control agreement satisfactory to Secured Party in its reasonable discretion and in any event sufficient to perfect a first priority lien and security interest in such account in favor of Secured
Party. All funds in or transferred into any such account on or after the Closing Date shall be subject to the security interest granted under this Agreement. Each control agreement entered into pursuant to the above shall grant Secured Party control
of such securities, depository or disbursement account and provide that the applicable securities intermediary or depository institution, as the case may be, will comply with instructions originated by the Secured Party directing disposition of the
funds in such account without further consent by Debtor, provided, that Debtor shall have full access to such accounts and the funds therein until the earlier to occur of (A) an Event of Default or (B) Debtor shall have acted in a
fraudulent manner or shall have committed an act of fraud; 
 (r) Debtor agrees that it shall not, and shall not allow any of its
Subsidiaries to, without the prior written consent of Secured Party, which consent shall not be unreasonably withheld, purchase or acquire obligations or stock of, or any other interest in, any corporation or other entity (other than cash
equivalents and equity investments in its Subsidiaries existing as of the date hereof), or form any Subsidiary or enter into any partnership, joint venture or similar arrangement; and 
 (s) Debtor will not, and will not permit any Subsidiary to, directly or indirectly, engage in any transaction with any Affiliate, except where such
transactions are (i) on terms that are no less favorable to the Debtor or such Subsidiary than those which might be obtained at the time from unaffiliated third parties and (ii) entered into in the ordinary course of business. As used
herein, “Affiliate” of any person means (a) any person which, directly or indirectly, is in control of, is controlled by, or is under common control with such person, or (b) any person who is a partner, shareholder,
director or 

  

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officer (i) of such person, or (ii) of any person described in clause (a) above, and, for purposes of this definition, control of a person
shall mean the power, direct or indirect, (x) to vote 10% or more of the voting equity interests of such person, or (y) to direct or cause the direction of the management and policies of such person whether by contract or otherwise.
Notwithstanding the foregoing, Secured Party shall not be considered to be an “Affiliate” of Debtor or any Subsidiary. 
  

	3.	COLLATERAL; SUBSIDIARIES. 

 (a) Until repossession
of Collateral by Secured Party in the exercise of its remedies under Section 7 hereof, Debtor shall remain in possession of the Collateral, other than such portion of the Collateral as shall be located from time to time at the locations in
connection with the purification, packaging and storage arrangements more fully described in Schedule 3 attached hereto (the “Offsite Collateral”); except that the Secured Party shall have the right to possess (i) any
chattel paper or instrument that constitutes a part of the Collateral, and (ii) any other Collateral in which the Secured Party’s security interest may be perfected only by possession. Secured Party may inspect any of the Collateral during
normal business hours after giving Debtor reasonable prior notice. 
 (b) Debtor shall (i) use the Collateral only in its trade or
business, (ii) maintain all of the Collateral in good operating order and repair, normal wear and tear excepted, (iii) use and maintain the Collateral only in compliance with manufacturers recommendations and all applicable laws and
(iv) keep all of the Collateral free and clear of all liens, claims and encumbrances (except for Permitted Liens). 
 (c) Secured Party
does not authorize and Debtor agrees it shall not, and shall not allow any of its Subsidiaries to, without the prior written consent of Secured Party, which consent shall not be unreasonably withheld: 
 (i) part with possession of any of its assets (including without limitation in respect of Debtor, the Collateral) (except for (A) the Offsite
Collateral, (B) to Secured Party, (C) for maintenance and repair, (D) any sale or disposition of inventory in the ordinary course of business or the sale of equipment or other assets which are determined by the Debtor in good faith to
be obsolete or no longer used or useful in Debtor’s business and (E) any non-exclusive licenses of Intellectual Property entered into in the ordinary course of business); 
 (ii) remove any of the Collateral from the continental United States (except for that portion of the Offsite Collateral which from time to time shall be
located in Europe as set forth in Schedule 3 attached hereto or any sale or disposition of inventory in the ordinary course of business); or 
 (iii) sell, rent, lease, mortgage, license, grant a security interest in or otherwise transfer or encumber (except for Permitted Liens) any of its assets (including, without limitation, in respect of Debtor, the Collateral) (except for
(A) any sale or disposition of inventory in the ordinary course of business, (B) the sale of equipment or 

  

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other assets which are determined by the Debtor in good faith to be obsolete or no longer used or useful in Debtor’s business, (C) transfers of
Intellectual Property expressly permitted under Section 2(m), and (D) liens on assets financed under capital leases, to the extent such the amount of related capital lease obligations together with other Debt permitted hereunder, do not
violate the terms of Section 2(o). 
 (d) Debtor shall pay promptly when due all taxes, license fees, assessments and public and private
charges levied or assessed on any of the Collateral, on its use, or on this Agreement or any of the other Debt Documents. At its option, Secured Party may discharge taxes, liens, security interests or other encumbrances at any time levied or placed
on the Collateral and may pay for the maintenance, insurance and preservation of the Collateral and effect compliance with the terms of this Agreement or any of the other Debt Documents. Debtor agrees to reimburse Secured Party, on demand, all
reasonable out-of-pocket costs and expenses incurred by Secured Party in connection with such payment or performance and agrees that such reimbursement obligation shall constitute Indebtedness. 
 (e) Debtor shall, at all times, keep accurate and complete records of the Collateral, and Secured Party shall have the right to inspect and make copies
of all of Debtor’s books and records relating to the Collateral during normal business hours, after giving Debtor reasonable prior notice. 
 (f) Debtor agrees and acknowledges that any third person who may at any time possess all or any portion of the Collateral shall be deemed to hold, and shall hold, the Collateral as the agent of, and as pledge holder for, Secured Party.
Secured Party may at any time give notice to any third person described in the preceding sentence that such third person is holding such Collateral as the agent of, and as pledge holder for, the Secured Party. 
 (g) Upon reasonable notice to Debtor (unless a default or Event of Default has occurred hereunder), Debtor shall permit Secured Party or one or more
agents to perform, at Debtor’s expense, appraisals of Collateral, field examinations, collateral analysis, monitoring or other business analysis as reasonable required by Secured Party and shall provide Secured Party with access to all
facilities and all books and records of Debtor reasonably required by Secured Party to conduct such audits, provided that, Debtor shall not be obligated to pay for more than one real estate appraisal and one equipment appraisal during each fiscal
year unless a default or Event of Default has occurred hereunder or Secured Party is otherwise insecure as to the value of the Collateral. For purposes of this subsection (g), the term “Collateral” shall include, without limiting the items
of collateral identified as “Collateral” in this Agreement, the real property, improvements, fixtures, personalty, plans, leases, lease guaranties, rents, property agreements and all other items of collateral identified as
“Collateral” in the Mortgage. Any appraisals hereunder of Collateral shall be in form and substance reasonably acceptable to Secured Party and any appraisals hereunder of Collateral that is real property shall be prepared by an independent
MAI appraiser in accordance with the Financial Institutions Reform, Recovery and Enforcement Act and the regulations promulgated pursuant to such act. 
  

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	4.	INSURANCE. 

 (a) Debtor shall at all times bear the
entire risk of any loss, theft, damage to, or destruction of, any of the Collateral from any cause whatsoever other than the gross negligence or willful misconduct of the Secured Party. 
 (b) Debtor agrees to keep the Collateral insured against loss or damage by fire and extended coverage perils, theft, burglary, and for any or all
Collateral which are vehicles, for risk of loss by collision, and if requested by Secured Party, against such other risks as Secured Party may reasonably require. The insurance coverage shall be in an amount no less than the full replacement value
of the Collateral, and deductible amounts, insurers and policies shall be acceptable to Secured Party. Debtor shall deliver to Secured Party policies or certificates of insurance evidencing such coverage. Each policy shall name Secured Party as
additional insured and lender’s loss payee, shall provide for coverage to Secured Party regardless of the breach by Debtor of any warranty or representation made therein, shall not be subject to co-insurance and shall provide that coverage may
not be canceled or altered by the insurer except upon thirty (30) days prior written notice to Secured Party. Debtor appoints Secured Party as its attorney-in-fact to make proof of loss, claim for insurance and adjustments with insurers and to
receive payment of and execute or endorse all documents, checks or drafts in connection with insurance payments. Secured Party shall not act as Debtor’s attorney-in-fact unless Debtor is in default. Proceeds of insurance in excess of $100,000
per claim shall be applied, at the option of Secured Party, to repair or replace the Collateral or to reduce any of the Indebtedness. Proceeds of insurance below $100,000 per claim shall be applied, at the option of Debtor, to repair or replace the
Collateral or to reduce any of the Indebtedness. 
  

	5.	REPORTS. 

 (a) Debtor shall promptly notify Secured
Party of (i) any change in the name of Debtor, (ii) any change in the state of its incorporation, organization or registration, (iii) any relocation of its chief executive offices, (iv) any relocation of any of the Collateral,
(v) any of the Collateral being lost, stolen, missing, destroyed, materially damaged or worn out or (vi) any lien, claim or encumbrance other than Permitted Liens attaching to or being made against any of the Collateral. Debtor shall
promptly deliver to Secured Party, at Secured Party’s request, reports specifying the location and value of the Offsite Collateral. 
 (b) Debtor will deliver to Secured Party financial statements as follows: (i) monthly financial statements, including a balance sheet, statement of operations and cash flow statement within 30 days of each month end,
(ii) quarterly unaudited financial statements within 30 days of each quarter end (or, if Borrower is a publicly held company, within 10 days after the statements are provided to the SEC), and (iii) complete audited annual financial
statements, certified by a recognized firm of certified public accountants, within 120 days of fiscal year end or at such time as Debtor’s Board of Directors receives the audit (or, if Borrower is a publicly held company, within 10 days after
the statements are provided to the SEC). All such statements are to be prepared 

  

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using generally accepted accounting principles (“GAAP”), except that monthly financial statements shall be prepared on an internal
accounting basis only and, if Debtor is a publicly held company, are to be in compliance with SEC requirements. All quarterly and year end financial statements shall be accompanied by (i) a management discussion and analysis that includes a
comparison of performance for such fiscal period to the corresponding period in the prior year and (ii) a compliance certificate, signed by the chief financial officer of the Debtor, in the form attached hereto as Exhibit A. 

 

	6.	FURTHER ASSURANCES. 

 (a) Debtor shall upon request
of Secured Party, furnish to Secured Party such further information, execute and deliver to Secured Party such documents and instruments (including, without limitation, Uniform Commercial Code financing statements) and shall do such other acts and
things as Secured Party may at any time reasonably request relating to the perfection or protection of the security interest created by this Agreement or for the purpose of carrying out the intent of this Agreement. Without limiting the foregoing,
Debtor shall cooperate and do all acts reasonably deemed necessary or advisable by Secured Party to continue in Secured Party a perfected priority security interests in the Collateral, and shall, subject to the terms of the Loan Agreement, use
commercially reasonable efforts to obtain and furnish to Secured Party any subordinations, releases, landlord waivers, lessor waivers, mortgagee waivers, or control agreements, and similar documents as may be from time to time requested by, and in
form and substance reasonably satisfactory to, Secured Party. 
 (b) In the event that the European marketing rights to ATryn are transferred
to a Subsidiary of the Debtor, the Debtor will, concurrently therewith, execute a pledge agreement in form and substance satisfactory to the Secured Party and take such other actions reasonably requested by the Secured Party in order to cause the
equity interests of such Subsidiary to be pledged to the Secured Party as security for the Indebtedness and to cause such pledge to be properly perfected as a first priority security interest; provided however, that with respect to any Subsidiary of
the Debtor that is organized under the laws of any jurisdiction other than the United States of America (each “Foreign Subsidiary”), at no time shall the equity interests so pledged exceed 65% of the issued and outstanding equity
interests of such Foreign Subsidiary. 
 (c) In the event that any Subsidiary of the Debtor becomes a “significant subsidiary”, the
Debtor will, concurrently therewith, execute a pledge agreement in form and substance satisfactory to the Secured Party and take such other actions reasonably requested by the Secured Party in order to cause the equity interests of such Subsidiary
to be pledged to the Secured Party as security for the Indebtedness and to cause such pledge to be properly perfected as a first priority security interest; provided however, that with respect to any Foreign Subsidiary, at no time shall the equity
interests so pledged exceed 65% of the issued and outstanding equity interests of such Foreign Subsidiary. 
 (d) Debtor authorizes Secured
Party to file a financing statement and amendments thereto describing the Collateral and containing any other information required by the applicable Uniform Commercial Code. Debtor irrevocably grants to 

  

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Secured Party the power to sign Debtor’s name and generally to act on behalf of Debtor to execute and file applications for title, transfers of title,
financing statements, notices of lien and other documents pertaining to any or all of the Collateral; this power is coupled with Secured Party’s interest in the Collateral. Debtor shall, if any certificate of title be required or permitted by
law for any of the Collateral, obtain and promptly deliver to the Secured Party such certificate showing the lien of this Agreement with respect to the Collateral. Debtor ratifies its prior authorization for Secured Party to file financing
statements and amendments thereto describing the Collateral and containing any other information required by the Uniform Commercial Code if filed prior to the date hereof. 
  

	7.	DEFAULT AND REMEDIES. 

 (a) Debtor shall be in
default under this Agreement and each of the other Debt Documents upon the occurrence and during the continuance of any of the following events or circumstances (each an “Event of Default”): 
 (i) Debtor breaches its obligation to pay when due any installment or other amount due or coming due under any of the Debt Documents and fails to cure
the breach within three (3) days; 
 (ii) Debtor, without the prior written consent of Secured Party, (A) attempts to or does sell,
rent, lease, license, mortgage, grant a security interest in, or otherwise transfer or encumber (except for Permitted Liens) any of the Collateral, except for any sale or disposition of inventory in the ordinary course of business, or the sale of
equipment or other assets which are determined by the Debtor in good faith to be obsolete or no longer used or useful in Debtor’s business or (B) breaches any of its obligations under Sections 2(n), (o), (p), (q), (r) or (s) or
3(a) hereof; 
 (iii) Debtor breaches any of its insurance obligations under Section 4; 
 (iv) Debtor breaches any of its other obligations under any of the Debt Documents and fails to cure that breach within ten (10) days after written
notice from Secured Party; 
 (v) Any warranty, representation or statement made by Debtor in any of the Debt Documents or otherwise in
connection with any of the Indebtedness shall be false or misleading in any material respect when made; 
 (vi) Any of the Collateral is
subjected to attachment, execution, levy, seizure or confiscation in any legal proceeding or otherwise and such attachment, seizure or levy is not removed in ten (10) days or if any legal or administrative proceeding is commenced against Debtor
or any of the Collateral, which in the good faith judgment of Secured Party subjects any of the Collateral to a material risk of attachment, execution, levy, seizure or confiscation and no bond is posted or protective order obtained to negate such
risk; 
  

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 (vii) If there is a material breach or an event of default by Debtor under any other agreement between
Debtor and Secured Party, which remains unwaived or uncured beyond the expiration of any applicable notice and/or grace period; 
 (viii)
Debtor, any significant Subsidiary, or any guarantor or other obligor for any of the Indebtedness (collectively “Guarantor”) dissolves, terminates its existence, becomes insolvent or ceases to do business as a going concern;

 (ix) If Debtor, any Subsidiary, or any Guarantor is a natural person, Debtor or any such Guarantor dies or becomes incompetent;

 (x) A receiver is appointed for all or of any material part of the property of Debtor or any Subsidiary, or Debtor or any Subsidiary makes
any assignment for the benefit of creditors. 
 (xi) Debtor, any Subsidiary or any Guarantor files a petition under any bankruptcy,
insolvency or similar law, or any such petition is filed against Debtor, any Subsidiary or any Guarantor and is not dismissed within sixty (60) days; 
 (xii) Debtor’s improper filing of an amendment or termination statement relating to a filed financing statement describing the Collateral; 
 (xiii) There is a material adverse change in the Debtor’s financial condition and operations as determined in the commercially reasonable judgment
of Secured Party; provided, however, that such a change will not be deemed to have occurred solely because of the occurrence of any of the following individual events: (a) negative responses from regulatory agencies; (b) negative clinical
trial results; (c) a low cash position; (d) fluctuations in revenues; or (e) continuing losses from operations; provided, further, however, that (I) the occurrence of any of (a), (b) or (c) may form the basis on which
the Secured Party reasonably determines that a material adverse change has occurred if any such event occurs in combination with one or more of the others of (a), (b) and (c) and (II) the occurrence of any of (a), (b), and (c), may form
the basis on which the Secured Party reasonably determines that a material adverse change has occurred if any such event occurs with other adverse changes in Debtor’s financial condition; 
 (xiv) Any Guarantor revokes or attempts to revoke its guaranty of any of the Indebtedness or fails to observe or perform any covenant, condition or
agreement to be performed under any guaranty or other related document to which it is a party; 
 (xv) Debtor defaults under any other
obligation in excess of $100,000 for (A) borrowed money, (B) the deferred purchase price of property or (C) payments due under any lease agreement; 
 (xvi) At any time during the term of this Agreement Debtor experiences a change in control such that any person or entity acquires either more than 50% of the voting stock of Debtor or sells all or substantially all
of its assets, in either case, without Secured Party’s prior written consent (a “Change in Control”). Notwithstanding the 

  

 12 

 
foregoing, it shall not be an Event of Default and no prior written consent shall be required if there is a Change in Control in which Secured Party acquires
more than 50% of the voting stock of Debtor; or 
 (xvii) Debtor or any Guarantor or other obligor for any of the Indebtedness sells,
licenses, sublicenses, transfers, assigns, mortgages, pledges, leases, grants a security interest in or encumbers any or all of Debtor’s Intellectual Property now existing or hereafter acquired, except for Permitted Liens as defined in
subsection (k) of Section 2. “Intellectual Property” shall, with respect to Debtor or any Subsidiary, be used as defined in Collateral Schedule No. 1. For purposes of this paragraph (xvii) only, licenses,
sublicenses or marketing rights granted by the Debtor of its Intellectual Property pursuant to Section 2(m) shall be excluded from the definition of Intellectual Property. Debtor shall provide Secured Party with a listing of licenses,
sublicenses and marketing rights granted to third parties within ten (10) days of receipt of written request. 
 (b) Upon the occurrence
and during the continuance of any Event of Default (other than a default under Section 7(a)(viii), (x) or (xi) or if Debtor shall have acted in a fraudulent manner or shall have committed an act of fraud), the Secured Party, at its
option, may declare any or all of the Indebtedness to be immediately due and payable, without demand or notice to Debtor or any Guarantor. If Borrower is in default under Section 7(a)(viii), (x) or (xi) or if Debtor shall have acted
in a fraudulent manner or shall have committed an act of fraud, then the Indebtedness shall immediately become due and payable, without demand or notice to Debtor or any Guarantor. The accelerated obligations and liabilities shall bear interest
(both before and after any judgment) until paid in full at the lower of eighteen percent (18%) per annum or the maximum rate not prohibited by applicable law. 
 (c) Upon the occurrence and during the continuance of any Event of Default or if Debtor shall have acted in a fraudulent manner or shall have committed an act of fraud, Secured Party shall have all of the rights and
remedies of a Secured Party under the Uniform Commercial Code and under any other applicable law. Without limiting the foregoing, Secured Party shall have the right to (i) notify any account debtor of Debtor or any obligor on any instrument
which constitutes part of the Collateral to make payment to the Secured Party, (ii) with or without legal process, enter any premises where the Collateral may be and take possession of and remove the Collateral from the premises or store it on
the premises, (iii) sell the Collateral at public or private sale, in whole or in part, and have the right to bid and purchase at said sale or (iv) lease or otherwise dispose of all or part of the Collateral, applying proceeds from such
disposition to the obligations then in default. If requested by Secured Party, Debtor shall promptly assemble the Collateral and make it available to Secured Party at a place to be designated by Secured Party which is reasonably convenient to both
parties. Secured Party may also render any or all of the Collateral unusable at the Debtor’s premises and may dispose of such Collateral on such premises without liability for rent or costs. Any notice that Secured Party is required to give to
Debtor under the Uniform Commercial Code of the time and place of any public sale or the time after which any private sale or other intended disposition of the Collateral is to be made shall be deemed to constitute reasonable notice 

  

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if such notice is given to the last known address of Debtor at least ten (10) days prior to such action. 
 (d) Proceeds from any sale or lease or other disposition shall be applied: first, to all costs of repossession, storage, and disposition including
without limitation attorneys’, appraisers’, and auctioneers’ fees; second, to discharge the obligations then in default; third, to discharge any Indebtedness of Debtor to Secured Party in connection with the Secured Note; fourth, to
discharge any Indebtedness of Debtor to Secured Party in connection with the 2009 Convertible Note; fifth, to discharge any Indebtedness of Debtor to Secured Party in connection with the 2008 Convertible Note, sixth, to discharge any Indebtedness of
Debtor to Secured Party in connection with the 2006 Convertible Note; seventh, to discharge any other Indebtedness of Debtor to Secured Party, whether as obligor, endorser, guarantor, surety or indemnitor; eighth, to reasonable, out-of-pocket
expenses incurred in paying or settling liens and claims against the Collateral; and lastly, to Debtor, if there exists any surplus. Debtor shall remain fully liable for any deficiency. 
 (e) Debtor agrees to pay all reasonable attorneys’ fees and other costs incurred by Secured Party (including without limitation the allocated cost
of in-house counsel) in connection with the enforcement, assertion, defense or preservation of Secured Party’s rights and remedies under this Agreement, or if prohibited by law, such lesser sum as may be permitted. Debtor further agrees that
such fees and costs shall constitute Indebtedness. 
 (f) Secured Party’s rights and remedies under this Agreement or otherwise arising
are cumulative and may be exercised singularly or concurrently. Neither the failure nor any delay on the part of the Secured Party to exercise any right, power or privilege under this Agreement shall operate as a waiver, nor shall any single or
partial exercise of any right, power or privilege preclude any other or further exercise of that or any other right, power or privilege. SECURED PARTY SHALL NOT BE DEEMED TO HAVE WAIVED ANY OF ITS RIGHTS UNDER THIS AGREEMENT OR UNDER ANY OTHER
AGREEMENT, INSTRUMENT OR PAPER SIGNED BY DEBTOR UNLESS SUCH WAIVER IS EXPRESSED IN WRITING AND SIGNED BY SECURED PARTY. A waiver on any one occasion shall not be construed as a bar to or waiver of any right or remedy on any future occasion.

 (g) DEBTOR AND SECURED PARTY UNCONDITIONALLY WAIVE THEIR RIGHTS TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION BASED UPON OR ARISING OUT
OF THIS AGREEMENT, ANY OF THE OTHER DEBT DOCUMENTS, ANY OF THE INDEBTEDNESS SECURED HEREBY, ANY DEALINGS BETWEEN DEBTOR AND SECURED PARTY RELATING TO THE SUBJECT MATTER OF THIS TRANSACTION OR ANY RELATED TRANSACTIONS, AND/OR THE RELATIONSHIP THAT IS
BEING ESTABLISHED BETWEEN DEBTOR AND SECURED PARTY. THE SCOPE OF THIS WAIVER IS INTENDED TO BE ALL ENCOMPASSING OF ANY AND ALL DISPUTES THAT MAY BE FILED IN ANY COURT. THIS WAIVER IS IRREVOCABLE. THIS WAIVER MAY NOT BE MODIFIED EITHER ORALLY OR IN
WRITING. THE 

  

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WAIVER ALSO SHALL APPLY TO ANY SUBSEQUENT AMENDMENTS, RENEWALS, SUPPLEMENTS OR MODIFICATIONS TO THIS AGREEMENT, ANY OTHER DEBT DOCUMENTS, OR TO ANY OTHER
DOCUMENTS OR AGREEMENTS RELATING TO THIS TRANSACTION OR ANY RELATED TRANSACTION. THIS AGREEMENT MAY BE FILED AS A WRITTEN CONSENT TO A TRIAL BY THE COURT. 
  

	8.	MISCELLANEOUS. 

 (a) This Agreement, any Note and/or
any of the other Debt Documents may be assigned, in whole or in part, by Secured Party without notice to Debtor, and Debtor agrees not to assert against any such assignee, or assignee’s assigns, any defense, set-off, recoupment claim or
counterclaim which Debtor has or may at any time have against Secured Party for any reason whatsoever. Debtor agrees that upon receipt of written notice of an assignment from Secured Party, Debtor will pay all amounts payable under any assigned Debt
Documents to such assignee or as instructed by Secured Party. Debtor also agrees to confirm in writing receipt of the notice of assignment as may be reasonably requested by Secured Party or assignee. 
 (b) All notices to be given in connection with this Agreement shall be in writing, shall be addressed to the parties at their respective addresses set
forth in this Agreement (unless and until a different address may be specified in a written notice to the other party), and shall be deemed given (i) on the date of receipt if delivered in hand or by facsimile transmission, (ii) on the
next business day after being sent by express mail and (iii) on the fourth business day after being sent by regular, registered or certified mail. As used herein, the term “business day” shall mean and include any day other than
Saturdays, Sundays, or other days on which commercial banks in Boston, Massachusetts are required or authorized to be closed. 
 (c) Debtor
agrees to pay all reasonable attorneys’ fees and all other fees, costs and expenses incurred by Secured Party (including, without limitation, the allocated cost of in-house legal counsel) in connection with the preparation, negotiation and
closing of the transactions contemplated in this Agreement and all related documents and schedules and in connection with the continued administration thereof, including, without limitation, any amendments, modifications, consents or waivers thereof
and in connection with the protection, monitoring or preservation of the Collateral, provided, however, that in no event shall such fees and expenses paid on or about the date hereof exceed $50,000. Debtor further agrees that such fees and costs
shall constitute Indebtedness. 
 (d) Secured Party may correct patent errors and fill in all blanks in this Agreement or in any Collateral
Schedule consistent with the agreement of the parties. 
 (e) Time is of the essence of this Agreement. This Agreement shall be binding,
jointly and severally, upon all parties described as the “Debtor” and their respective heirs, executors, representatives, successors and assigns, and shall inure to the benefit of Secured Party, its successors and assigns. 
  

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 (f) This Agreement and its Collateral Schedules constitute the entire agreement between the parties with
respect to the subject matter of this Agreement and supersede all prior understandings (whether written, verbal or implied) with respect to such subject matter. THIS AGREEMENT AND ITS COLLATERAL SCHEDULES SHALL NOT BE CHANGED OR TERMINATED ORALLY OR
BY COURSE OF CONDUCT, BUT ONLY BY A WRITING SIGNED BY BOTH PARTIES. Section headings contained in this Agreement have been included for convenience only, and shall not affect the construction or interpretation of this Agreement. 
 (g) This Agreement shall continue in full force and effect until all of the Indebtedness has been paid in full to Secured Party or its assignee. The
surrender, upon payment or otherwise, of any promissory notes or any of the other documents evidencing any of the Indebtedness shall not affect the right of Secured Party to retain the Collateral for such other Indebtedness as may then exist or as
it may be reasonably contemplated will exist in the future. This Agreement shall automatically be reinstated if Secured Party is ever required to return or restore the payment of all or any portion of the Indebtedness (all as though such payment had
never been made). 
 (h) Debtor authorizes Secured Party to use its name, logo and/or trademark upon prior written consent of the Debtor,
which consent shall not be unreasonably withheld, in connection with certain promotional materials that Secured Party may disseminate to the public. The promotional materials may include, but are not limited to, brochures, video tape, internet
website, press releases, advertising in newspaper and/or other periodicals, lucites, and any other materials relating the fact that Secured Party has a financing relationship with Debtor. Nothing herein obligates Secured Party to use Debtor’s
name, logo and/or trademark, in any promotional materials of Secured Party. 
 (i) THIS AGREEMENT AND THE RIGHTS AND OBLIGATIONS OF THE
PARTIES HEREUNDER SHALL IN ALL RESPECTS BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH, THE INTERNAL LAWS OF THE COMMONWEALTH OF MASSACHUSETTS WITHOUT GIVING EFFECT TO ANY CHOICE OF LAW OR CONFLICT OF LAW PROVISION OR RULE (WHETHER OF THE
COMMONWEALTH OF MASSACHUSETTS OR ANY OTHER JURISDICTIONS) THAT WOULD CAUSE THE APPLICATION OF THE LAWS OF ANY JURISDICTIONS OTHER THAN THE COMMONWEALTH OF MASSACHUSETTS. IF ANY PROVISION OF THIS AGREEMENT SHALL BE INVALID OR UNENFORCEABLE IN ANY
JURISDICTION, SUCH INVALIDITY OR UNENFORCEABILITY SHALL NOT AFFECT THE VALIDITY OR ENFORCEABILITY OF THE REMAINDER OF THIS AGREEMENT IN THAT JURISDICTION OR THE VALIDITY OR ENFORCEABILITY OF ANY PROVISION OF THIS AGREEMENT IN ANY OTHER JURISDICTION.

 (j) Debtor shall indemnify Secured Party and its officers, directors, affiliates, employees and agents from and against any and all
liabilities, obligations, losses, damages, penalties, actions, judgments, suits, costs, expenses and disbursements of any kind or nature whatsoever (including without limitation reasonable fees and disbursements of counsel and allocated costs of
in-house counsel) which may be imposed 

  

 - 16 - 

 
upon, incurred by or asserted against Secured Party in any litigation, proceeding or investigation instituted or conducted by any governmental authority or
instrumentality or any other person with respect to any aspect of, or any transaction contemplated by, or referred to in, or any matter related to this Agreement or the Debt Documents, whether or not Secured Party is a party thereto, except to the
extent that any of the foregoing arises out of the gross negligence or willful misconduct of the party being indemnified as determined by a final non-appealable judgment of a court of competent jurisdiction. 
 (k) Notices. All notices to be given in connection with this Agreement shall be in writing, shall be addressed to the parties at their respective
addresses set forth in this Agreement (unless and until a different address may be specified in a written notice to the other party), and shall be deemed given: (i) on the date of receipt if delivered by hand; (ii) on the next business day
after being sent by overnight courier service; and (iii) on the third business day after being sent by regular, registered or certified mail. As used herein, the term “business day” shall mean and include any day other than Saturdays,
Sundays, or other days on which commercial banks in Boston, Massachusetts are required or authorized by law to be closed. 
 If to Debtor:

  

			
	 GTC Biotherapeutics, Inc.
 175 Crossing
Boulevard
 Suite 410

	Framingham, MA 01702
	Telephone:	 	(508) 370-2061
	Facsimile:	 	(508) 271-3491
	Attention:	 	Geoffrey F. Cox, Ph.D.
		 	Chairman, President and Chief Executive Officer

 with a copy to: 
  

			
	 Edwards Angell Palmer & Dodge LLP
 111
Huntington Avenue
 Boston, MA 02299

	Tel:	 	(617) 239-0100
	Fax:	 	(617) 227-4420
	Attn:	 	Nathaniel S. Gardiner, Esq.

 If to the Secured Party: 
  

			
	 LFB Biotechnologies S.A.S.
 3, avenue des
Tropiques
 LES ULIS
 91940 Courtaboeuf -
France

	Tel:	 	+33 (0) 1 69 82 70 10
	Fax:	 	+33 (0) 1 6982 72 67
	Attn:	 	M. Christian Bechon, President

  

 - 17 - 

 with a copy to: 
  

			
	 Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
 One Financial Center
 Boston, MA 02211

	Tel:	 	(617) 542-6000
	Fax:	 	(617) 542-2241
	Attn:	 	Brian P. Keane, Esq.

 [Signatures on following page] 
  

 - 18 - 

 IN WITNESS WHEREOF, Debtor and Secured Party, intending to be legally bound hereby, have duly
executed this Agreement in one or more counterparts, each of which shall be deemed to be an original, as of the day and year first aforesaid. 
  

									
	SECURED PARTY:	 		 	DEBTOR:
			
	LFB Biotechnologies S.A.S.	 		 	GTC Biotherapeutics, Inc.
					
	By:	 	 /s/ Max Berger
	 		 	By:	 	 /s/ John B. Green

		 	Max Berger, Director of Legal Affairs, for and on behalf of Christian Bechon, President Directeur General, by Power of Attorney dated June 18, 2009	 		 	Name:	 	John B. Green
		 	 		 	Title:	 	Senior Vice President, Chief Financial Officer and Treasurer

 [Signature page to Amended and Restated Security Agreement] 

 COLLATERAL SCHEDULE NO. 001 
 Part of Amended and Restated Security Agreement dated as of the 18th day of June, 2009, as amended, restated, supplemented or otherwise modified from
time to time (the “Contract”) between LFB BIOTECHNOLOGIES S.A.S. (the “Secured Party”) and GTC BIOTHERAPEUTICS, INC. (the “Debtor”). 
 As security for the full and faithful payment of all Indebtedness (as defined in the Contract) owing by Debtor to Secured party and performance by the
Debtor of all of the terms and conditions upon the Debtor’s part to be performed under the Contract and any other obligation of the Debtor to the Secured Party now or hereafter in existence, the Debtor does hereby grant to the Secured Party a
security interest in the property listed below (all hereinafter collectively called the “Collateral”): 
 All of the
Debtor’s personal property of every kind and nature, including without limitation all accounts, chattel paper, commercial tort claims, deposit accounts, documents, goods, equipment, fixtures, instruments, investment property, inventory,
Intellectual Property, letter-of-credit rights, letters of credit, supporting obligations, any other contract rights or rights to the payment of money, and general intangibles (excluding from this Collateral Schedule No. 1, all livestock now
owned or hereafter acquired, whether now owned or hereafter arising or acquired by the Debtor), together with all accessions and additions thereto, proceeds and products thereof (including, without limitation, any proceeds resulting under insurance
policies), and substitutions and replacements therefor (with each of the foregoing terms that are defined in the Uniform Commercial Code as in effect in the Commonwealth of Massachusetts (“UCC”) having the meaning set forth in the
UCC). For purposes of this Collateral Schedule No. 1, “Intellectual Property” shall, with respect to Debtor or any Subsidiary, be defined as any and all copyright, trademark, tradename, servicemark, patent, invention, design, design
right, software and databases, trade secret, customer lists, know-how and intangible rights of Debtor, any marketing rights granted by Debtor, and any goodwill, applications, registrations, claims, licenses, products, proceeds, awards, judgments,
amendments, renewals, extensions, improvements and insurance claims related thereto now or hereafter owned or licensed by Debtor, or any claims for damages by way of any past, present or future infringement of any of the foregoing, together with all
accessions and additions thereto, proceeds and products thereof (including, without limitation, any proceeds resulting under insurance policies), provided further that the Collateral shall include without limitation, all accounts and general
intangibles that consist of rights of payment and proceeds from the sale, licensing or disposition of all or any part, or rights in, the foregoing. 
 In the event of a default by the Debtor with respect to any of the conditions, terms, covenants and provisions under the Contract or other agreement, Secured Party shall have the rights and remedies provided under the Contract and/or of a
secured party under the UCC with respect to the Collateral. The Debtor shall have the same obligations 

  

 - 20 - 

 
with respect to the Collateral as it has under the Contract with respect to the Collateral financed. 
 This Agreement shall run to the benefit of the Secured Party’s successors and assigns. 
  

 - 21 - 

 IN WITNESS WHEREOF, the undersigned has executed this Collateral Schedule No. 001 as of the
date first written above. 
  

			
	GTC BIOTHERAPEUTICS, INC.
		
	By:	 	 /s/ John B. Green

	Name:	 	John B. Green
	Title:	 	Senior Vice President, Chief Financial Officer and Treasurer

 [Signature page to Collateral Schedule No. 001] 

 Exhibit A 
 COMPLIANCE CERTIFICATE 
 [DATE] 
 Reference is made to the Amended and Restated Security Agreement, dated as of June 18, 2009 (as amended, restated, supplemented or otherwise modified from time to time, the “Security Agreement”),
among GTC BIOTHERAPEUTICS, INC., a Massachusetts corporation (the “Debtor”), and LFB Biotechnologies, S.A.S., (“Secured Party”). Capitalized terms used but not defined herein are used with the meanings assigned to
such terms in the Security Agreement. 
 I,
[                    ], do hereby certify that: 
 (i) I am the duly elected, qualified and acting [TITLE] of Debtor; 
 (ii) attached hereto as Exhibit A are [quarterly
financial statements]/[annual audited financial statements] as required under Section 5(b) of the Security Agreement and that such financial statements are prepared in accordance with GAAP and are consistently applied from one
period to the next except as explained in an accompanying letter or footnotes; 
 (iii) no Event of Default has occurred under the Security Agreement which
has not been previously disclosed, in writing, to Secured Party; and 
 (iv) all representations and warranties of the Debtor stated in the Debt Documents
are true and correct in all material respects on and as of the date hereof, except to the extent such representations and warranties expressly relate to an earlier date, in which case such representations and warranties were true and correct in all
material respects on and as of such earlier date. 
 IN WITNESS WHEREOF, I have hereunto set my hand as of the first date written above. 

 

			
	  

	Name:	 	  

	Title:

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