Document:

EX-10.43

 Exhibit 10.43 
 AMENDMENT TO 
 EXECUTIVE EMPLOYMENT AGREEMENT 

This AMENDMENT TO EXECUTIVE EMPLOYMENT AGREEMENT (“Amendment”) is made and entered into as of the 30 day of
DECEMBER, 2008 by and between QUINTILES TRANSNATIONAL CORP., a North Carolina corporation (the “Company”), and JOHN D. RATLIFF (“Executive”). 

WHEREAS, Executive is currently employed under an Executive Employment Agreement with the Company, dated June 14, 2004 (the
“Employment Agreement”), and currently serves as Executive Vice President and Chief Operating Officer, directly reporting to the Chairman and Chief Executive Officer of the Company; 

WHEREAS, the Company and Executive amended the Employment Agreement by a letter to Executive from Michael Mortimer on behalf of
the Company dated September 19, 2006 (the “Letter Agreement”); 
 WHEREAS, the Company and Executive
desire to amend further the Employment Agreement to memorialize new compensation arrangements approved by the Company’s Board of Directors in November 2006 and December 2007 and to evidence compliance with Section 409A of the Internal
Revenue Code of 1986, as amended (the “Code”), and the regulations thereunder (collectively, “Section 409A”); and 
 NOW, THEREFORE, in consideration of the mutual covenants and agreements set forth below and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the
Company and Executive agree that the Employment Agreement, as amended by the Letter Agreement (the “Amended Employment Agreement”) shall be further amended as follows: 

1. COMPENSATION. Section 3, COMPENSATION, of the Amended Employment Agreement is deleted in its entirety and the
following Section is inserted in lieu thereof: 
 3. COMPENSATION. 

3.1 Base Salary. Executive’s annual salary for all services rendered shall be Five Hundred
Fifty Thousand and No/100 Dollars ($550,000.00) (less any applicable taxes and withholdings), payable in accordance with the Company’s policies, procedures, and practices as they may exist from time to time. Executive’s salary may be
reviewed and is subject to adjustment in accordance with the Company’s policies, procedures, and practices as they may exist from time to time. 
 3.2 Performance Incentive Plan. Executive may participate on a basis commensurate with his position as a senior executive 

 
officer, as determined by the Company, in the Quintiles Performance Incentive Plan. For the year 2008, Executive is eligible to participate at a target level of one hundred percent (100%) of
his annual base salary. This target level may be increased or decreased in subsequent years at the discretion of the Company. Beginning with the year 2008, the Performance Incentive Plan cap shall increase to two hundred percent (200%) of
target, based on Company and personal performance. Any Bonus paid to Executive shall be less applicable withholdings and shall be distributed pursuant to policies as determined by the Company, but in no event later than March 15 of the calendar
year following the calendar year in which such Bonus was earned. 
 3.3 Annual Executive
Allowance. Each year during the term of this Amended Employment Agreement, Executive shall be entitled to receive payment of Thirty Thousand and No/100 Dollars ($30,000.00), less any applicable taxes and withholdings, as an Executive
Allowance. The Executive Allowance shall be paid in substantially equal installment payments in accordance with the Company’s normal payroll practices. This Executive Allowance is intended to be used for miscellaneous expenses and allowances
previously provided by the Company such as car allowance, tax return preparation fees, financial planning fees, legal fees, and the micropurchase plan. 
 3.4 Other Benefits. Executive may participate in all medical, dental and disability insurance, 401(k), pension, personal leave, and other benefit plans and programs provided by the Company
to other employees at Executive’s level except that Executive may not receive severance payments other than as specified in this Amended Employment Agreement; provided, however, that Executive’s participation in such benefit plans and
programs is subject to the applicable terms, conditions and eligibility requirements of these plans and programs, some of which are in the plan administrator’s discretion, as they may exist from time to time. 

3.5 Business Expenses. Executive shall be reimbursed for reasonable and necessary expenses actually
incurred by him in performing services under this Amended Employment Agreement in accordance with and subject to the terms and conditions of the applicable Company reimbursement policies, procedures, and practices as they may exist from time to
time. Expenses covered by this provision include, but are not limited to, travel, entertainment, professional dues and subscriptions, and dues, fees, and expenses associated with membership in various professional and business and civic associations
in which Executive’s participation is in the Company’s best interest. All such reimbursements shall be made no later than March 15 of the calendar year following the calendar year in which the expenses were incurred. 

  
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 3.6 Modifications or Revisions of Benefit Plans and Programs.
Nothing in this Amended Employment Agreement shall require the Company to create, continue, or refrain from amending, modifying, revising, or revoking any of the plans, programs, or benefits set forth in Sections 3.2 through 3.5. Any amendments,
modifications, revisions, and revocations of these plans, programs, and benefits shall apply to Executive. 

3.7 Offset for Disability Payments. If, at any time, during which Executive is receiving salary or
post-termination payments from the Company, he receives payments on account of mental or physical disability from any Company-provided plan, then the Company, at its discretion, may reduce his salary or post-termination payments by the amount of
such disability payments.” 
 2. TERM OF EMPLOYMENT. Section 4, TERM OF EMPLOYMENT, of the Amended Employment
Agreement shall be amended as follows: 
 Executive’s Right to Terminate for a Breach by the
Company. Section 4.4 of the Amended Employment Agreement is deleted in its entirety and the following Section is inserted in lieu thereof: 
 “4.4 Executive may terminate employment in the event the Company materially breaches this Agreement if: (i) Executive provides the Company with written notice of the material breach of
this Agreement within ninety (90) days of the initial actions or inactions of the Company giving rise to such breach; (ii) the Company has not cured such breach within ninety (90) days of such notice (“Cure Period”); and
(iii) if the Company fails to cure such breach, Executive terminates employment under this Agreement within ninety (90) days of the expiration of the Cure Period.” 

  
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 3. COMPENSATION AND BENEFITS UPON TERMINATION. Section 5, COMPENSATION
AND BENEFITS UPON TERMINATION, of the Amended Employment Agreement shall be amended as follows: 
  

	 	(a)	Termination by the Company Without Cause or for Non-Renewal or by the Executive for a Material Breach. Section 5.2 (iii) of the Amended
Employment Agreement is deleted in its entirety and the following Section is inserted in lieu thereof: 

 “(iii) subject to Executive’s compliance with Sections 6, 7, 8 and 9, and subject to Sections 3.7 and 5.5, an amount equal to the sum of 1.55 times his then current monthly base salary (less
applicable withholdings) multiplied by thirty six (36), plus an amount equal to three times his Annual Executive Allowance under Section 3.3, such sum to be payable in lump sum (less applicable withholdings) within ten (10) calendar days
following the effective date of the general release required by Section 5.5, but not later than ninety (90) days following termination.” 
  

	 	(b)	Benefit Continuation. Section 5.3 of the Amended Employment Agreement is deleted in its entirety and the following Section is inserted in lieu
thereof: 

 “5.3 In the event Executive is receiving payments under Section 5.2 of the
Amended Employment Agreement, and subject to Executive’s compliance with Sections 6, 7, 8 and 9, and subject to Sections 3.7 and 5.5, Executive shall be entitled to a lump sum payment equal to thirty six (36) multiplied by the
Company’s monthly cost for providing the type of medical, dental, vision, long term disability and term life insurance coverage, as applicable, in effect for Executive (e.g., family coverage vs. employee-only coverage) at the time of his
termination, payable in a one-time lump sum payment, less any applicable tax withholdings, within ten (10) calendar days following the effective date of the general release required by Section 5.5, but not later than ninety (90) days
following termination from employment. Any payment under this section that is includible in Executive’s gross income shall be increased by an additional amount equal to the Federal income tax applicable to such payment determined by applying
the highest marginal Federal tax rate in effect at the payment date. Executive shall bear full responsibility for applying for COBRA continuation coverage and for obtaining coverage under any other insurance policy following termination of
employment, and nothing herein shall constitute a guarantee of COBRA continuation coverage or benefits or a guarantee of eligibility for health, dental, long term disability or term life insurance coverage.” 

 

	 	(c)	Release of Claims as a Condition of Payment from the Company. Section 5.5 of the Amended Employment Agreement is deleted in its entirety and the
following Section is inserted in lieu thereof: 

  
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 “5.5 Notwithstanding any provision of this Amended Employment
Agreement to the contrary, the Company’s obligation to provide the payments and benefits under Sections 5.2 and 5.3 of this Amended Employment Agreement is conditioned upon Executive’s execution of an enforceable release of claims and his
compliance with Sections 6, 7, 8 and 9 of this Amended Employment Agreement. If Executive chooses not to execute such a release or fails to comply with these sections, then the Company’s obligation to compensate him ceases on the effective
termination date except as to amounts due at the time and any amount subsequently due pursuant to the plan described in Section 3.2. The release of claims shall be provided to Executive within thirty (30) days of his separation from
service and Executive must execute it within the time period specified in the release (which shall not be longer than forty five (45) days from the date of receipt). Such release shall not be effective until any applicable revocation period has
expired.” 
 4. SECTION 409A OF THE INTERNAL REVENUE CODE. The following provisions shall be added to the end
of the Amended Employment Agreement as Section 19: 
 “19 Section 409A of the Internal
Revenue Code 
 19.1 Parties’ Intent. The parties intend that the provisions of this Amended
Employment Agreement comply with the Internal Revenue Code of 1986, as amended (the “Code”), and the regulations thereunder (collectively, “Section 409A”) and all provisions of this Amended Employment Agreement shall be construed
in a manner consistent with the requirements for avoiding taxes or penalties under Section 409A. If any provision of this Amended Employment Agreement (or of any award of compensation, including equity compensation or benefits) would cause
Executive to incur any additional tax or interest under Section 409A, the Company shall, upon the specific request of Executive, use its reasonable business efforts to in good faith reform such provision to comply with Code Section 409A;
provided, that to the maximum extent practicable, the original intent and economic benefit to Executive and the Company of the applicable provision shall be maintained, and the Company shall have no obligation to make any changes that could
create any additional economic cost or loss of benefit to the Company. The Company shall timely use its reasonable business efforts to amend any plan or program in which Executive participates to bring it in compliance with Section 409A.
Notwithstanding the foregoing, the Company shall have no liability with regard to any failure to comply with Section 409A so long as it has acted in good faith with regard to compliance therewith. 

19.2 Separation from Service. A termination of employment shall not be deemed to have occurred for purposes of any
provision of this Amended Employment Agreement providing for the payment of any amounts or benefits upon or following a termination of employment unless such termination also constitutes a “Separation from Service” within the meaning of
Section 409A and, 

  
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for purposes of any such provision of this Amended Employment Agreement, references to a “termination,” “termination of employment,” “separation from service” or
like terms shall mean Separation from Service. 
 19.3 Separate Payments. Each installment payment required
under this Amended Employment Agreement shall be considered a separate payment for purposes of Section 409A. 
 19.4
Delayed Distribution to Key Employees. If the Company determines in accordance with Sections 409A and 416(i) of the Code and the regulations promulgated thereunder, in the Company’s sole discretion, that Executive is a Key
Employee of the Company on the date his/her employment with the Company terminates and that a delay in benefits provided under this Amended Employment Agreement is necessary to comply with Code Section 409A(A)(2)(B)(i), then any severance
payments and any continuation of benefits or reimbursement of benefit costs provided by this Amended Employment Agreement, and not otherwise exempt from Section 409A, shall be delayed for a period of six (6) months following the date of
termination of Executive’s employment (the “409A Delay Period”). In such event, any severance payments and the cost of any continuation of benefits provided under this Amended Employment Agreement that would otherwise be due and
payable to Executive during the 409A Delay Period shall be paid to Executive in a lump sum cash amount in the month following the end of the 409A Delay Period. For purposes of this Amended Employment Agreement, “Key Employee” shall mean an
employee who, on an Identification Date (“Identification Date” shall mean each December 31) is a key employee as defined in Section 416(i) of the Code without regard to paragraph (5) thereof. If Executive is identified as a
Key Employee on an Identification Date, then Executive shall be considered a Key Employee for purposes of this Amended Employment Agreement during the period beginning on the first April 1 following the Identification Date and ending on the
following March 31.” 
 5. COUNTERPARTS. This Amendment may be executed in counterparts, each of which
shall be an original, with the same effect as if the signatures affixed thereto were upon the same instrument. 
 6.
DEFINITIONS. All terms used in this Amendment shall have the same definitions as used in the Amended Employment Agreement, unless otherwise provided herein. All references to “Amended Employment Agreement” shall include all
modifications made by this Amendment, unless provided otherwise. 
 7. EFFECT OF AMENDMENT. Except as amended
hereby, the Amended Employment Agreement shall remain in full force and effect and is hereby ratified and confirmed by the Company and Executive in all respects. 

  
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 [Remainder of page intentionally left blank] 

  
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 IN WITNESS WHEREOF, this Amendment has been duly executed as of the day and year set forth
above. 
  

					
	QUINTILES TRANSNATIONAL CORP.
		
	By:	 	 /s/ Michael Mortimer

		 	Name:	 	Michael Mortimer
		 	Title:	 	Executive Vice President and
Chief Administrative Officer
	
	EXECUTIVE:
	
	 /s/ John D. Ratliff

	John D. Ratliff

  
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 SUPPLEMENT TO 
 EXECUTIVE EMPLOYMENT AGREEMENT 
 This supplements that certain Executive
Employment Agreement by and between QUINTILES TRANSNATIONAL CORP. and JOHN D. RATLIFF dated June 14, 2004, as amended (the “Employment Agreement”). Pursuant to this supplement, if John D. Ratliff retires, elects not to renew
his Employment Agreement or otherwise voluntarily departs from service to Quintiles, he shall be entitled to the same benefits as the benefits owed to Mr. Ratliff had he been terminated without “Cause,” as described in the Employment
Agreement, including cash severance payments, insurance benefits and executive allowance benefits (each as described more fully in Mr. Ratliff’s Employment Agreement), which shall be calculated and payable upon the same terms and subject to the
same conditions (as set forth in his Employment Agreement) following the date his employment relationship with Quintiles ends. 
  

			
	QUINTILES TRANSNATIONAL CORP.
		
	By:	 	/s/ M Mortimer
		
	Name:	 	M Mortimer
		
	Title:	 	Executive Vice President  
		
	Date:	 	4.17.13
	
	EXECUTIVE:
		
		 	/s/ John D. Ratliff
	            John D. Ratliff
		
	Date:	 	4/18/2013EX-10.56

 Exhibit 10.56 
 QUINTILES TRANSNATIONAL HOLDINGS INC. 
 2013 STOCK INCENTIVE PLAN

 AWARD AGREEMENT 
 (Awarding Stock Appreciation Rights) 
 THIS AWARD AGREEMENT (this
“Agreement”) is made by and between Quintiles Transnational Holdings Inc., a North Carolina corporation (the “Company”), and «Name» (the “Participant”) pursuant to the provisions of the Quintiles
Transnational Holdings Inc. 2013 Stock Incentive Plan (the “Plan”), which is incorporated herein by reference. Capitalized terms not defined in this Agreement shall have the meanings given to them in the Plan. 

WITNESSETH: 

WHEREAS, the Participant is providing, or has agreed to provide, services to the Company, or Affiliate or a Subsidiary of the Company, as
an Employee, Director or Third Party Service Provider; and 
 WHEREAS, the Company considers it desirable and in its best
interests that the Participant be given a personal stake in the Company’s growth, development and financial success through the grant of stock appreciation rights as to the common stock of the Company. 

NOW, THEREFORE, in consideration of the premises and the mutual agreements set forth herein, the parties agree as follows: 

1. Grant of SARs. Effective as of «Grant Date» (the “Date of Grant”), the Company hereby grants to
the Participant stock appreciation rights with respect to «Number of Shares» shares of the Company’s common stock (the “SARs”), with a grant price of «Grant Price» (the “Grant Price”),
subject to the terms and conditions of the Plan and this Agreement. The SARs give the Participant upon exercise the right to receive in cash the difference between the Fair Market Value of a share of the Company’s common stock on the date of
exercise over the Grant Price multiplied by the number of SARs being exercised (the “Spread”). The future value of the Spread is unknown and cannot be predicted with certainty. If the shares of the Company’s common stock do not
increase in value, the SARs will have no value. 
 2. Term of SARs. Subject to earlier termination under Section 5
hereof, the term of the SARs shall be ten (10) years (the “Term”). 
 3. Vesting Schedule. The SARs shall
vest as to «Vesting Schedule». 
 In no event will any portion of the SARs that is not vested at the time of
the termination of the Participant’s service relationship become vested following such termination. Further, notwithstanding any provision of the Plan or this Agreement to the contrary, in no event will any portion of the SARs that is not
vested immediately prior to the time of a Sale of the Company become vested because of such event. 

 4. Exercisability of SARs. Subject to Sections 2 and 5 hereof, SARs shall be
exercisable when and as they vest. 
 5. Expiration of SARs. Any portion of the SARs in which the Participant is not
vested shall be forfeited and terminate on the date of the termination of the Participant’s service relationship for any reason. Subject to earlier termination under Section 2 hereof, any portion of the SARs in which the Participant is
vested shall be forfeited and terminate on the earlier of (the “Expiration Date”): 
  

	 	(a)	 The 91st day after termination of the Participant’s service relationship for any reason other than one specified in (b) or (c) below. 

 

	 	(b)	 The 366th day after termination of the Participant’s service relationship as a result of the Participant’s death, or a disability, retirement or redundancy that is approved by the Committee for this
purpose. 

  

	 	(c)	Termination of the Participant’s employment relationship by the Company for Cause, or of the Participant’s service relationship by the Company for reasons
that would constitute Cause if the Participant were an employee. 

 6. Exercise of SARs. SARs that
are exercisable under Section 4 hereof may be exercised by delivery of an exercise notice in the form attached as Exhibit A (the “Exercise Notice”) to the Company prior to the Expiration Date of the SARs. The SARs shall be
deemed exercised upon receipt by the Company of such fully executed Exercise Notice. 
 In connection with such exercise, the
Company shall have the right to require that the Participant make such provision, or furnish the Company such authorization, as may be necessary or desirable so that the Company may satisfy any obligation it has under applicable income tax laws to
withhold for income or other taxes due upon or incident to such exercise. 
 7. Payment. Upon valid exercise of the SARs,
the Company shall pay the Participant the Spread, less required withholding, in a cash lump sum within 30 days of such exercise, without interest thereon. 
 8. Participant’s Representations. The Participant acknowledges that he/she does not have any rights as a stockholder of the Company by reason of a grant of the SARs or settlement of the SARs
pursuant to the Plan or this Agreement. The Participant further acknowledges that the SARs only entitle the Participant, if at all, to a cash amount determined and payable pursuant to the terms of the Plan and this Agreement. The SARs do not
represent any right to receive actual shares of common stock or other equity securities of the Company. 
 The Participant
acknowledges that the Participant has received, read and understood the Plan and the Agreement and agrees to abide by and be bound by their terms and conditions. 

  
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 9. Non-Transferability of SARs. No portion of the SARs may be transferred in any
manner otherwise than by will or the laws of descent and distribution and, during the Participant’s lifetime, may only be exercised by the Participant. 
 10. Restrictions. This Agreement shall be subject to all applicable laws, rules, and regulations, and to such approvals by any governmental agencies or stock exchange as may be required. The
Participant agrees to take all steps the Committee determines are necessary to comply with all applicable provisions of federal and state securities law in exercising his or her rights under this Agreement. 

11. Forfeiture. Where a Participant engages in certain competitive activity or is terminated by the Company for Cause, his or her
SARs and any payments made in connection therewith are subject to forfeiture conditions under Section 11.3 of the Plan. 

12. Successors and Assigns. The Company may assign any of its rights under this Agreement to single or multiple assignees, and
this Agreement shall inure to the benefit of the successors and assigns of the Company. Subject to the restrictions on transfer herein set forth, the terms and conditions of the Plan and this Agreement shall be binding upon the Participant and his
or her heirs, executors, administrators, successors and assigns. 
 13. Interpretation. Any dispute regarding the
interpretation of this Agreement shall be submitted by the Participant or by the Company forthwith to the Committee, which shall review such dispute at its next regular meeting. The resolution of such a dispute by the Committee shall be final and
binding on all parties. 
 14. Tax Consequences and Withholding. The exercise of the SARs may cause the Participant to be
subject to federal, state and/or foreign taxation. The Participant should consult a tax advisor before exercising the SARs. The Company shall have the authority and the right to deduct or withhold, or to require the Participant to remit to the
Company, an amount sufficient to satisfy all applicable federal, state, and local taxes (including the Participant’s employment tax obligations) required by law to be withheld with respect to any taxable event arising in connection with the
SARs. Unless otherwise determined by the Committee, the Company shall, in satisfaction of the foregoing requirement, withhold on the amount deliverable to the Participant under Section 7 above to the extent required by applicable law, and the
Participant hereby agrees to such withholding. 
 15. Acknowledgement. The Participant acknowledges and agrees:
(i) that the Plan is discretionary in nature and may be suspended or terminated by the Company at any time; (ii) that the grant of SARs does not create any contractual or other right to receive future grants of SARs or any right to
continue an employment or other relationship with the Company (for the vesting period or otherwise); (iii) that the Participant remains subject to discharge from such relationship to the same extent as if the SARs had not been granted;
(iv) that all determinations with respect to any such future grants, including, but not limited to, when and on what terms they shall be made, will be at the sole discretion of the Committee; (v) that participation in the Plan is
voluntary; (vi) that the value of the SARs is an extraordinary item of compensation that is outside the scope of the Participant’s employment contract if any; and (vii) that the SARs are not part of normal or expected compensation for
purposes of calculating any severance, resignation, 

  
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redundancy, end of service payments, bonuses, long-service awards, pension or retirement benefits or similar benefits. 
 16. Section 409A. The SARs are intended to be exempt from the provisions of Section 409A of the Internal Revenue Code and Department of Treasury regulations and other interpretive
guidance issued thereunder, as providing for a right to compensation based on the appreciation in value of a specified number of shares of service recipient stock as described in Section 1.409A-1(b)(5)(i)(B) of the Department of Treasury
regulations. Notwithstanding any provision of the Plan or this Agreement to the contrary, in the event that the Committee determines that the SARs may be subject to Section 409A of the Code and related Department of Treasury guidance (including
such Department of Treasury guidance as may be issued after the date hereof), the Committee may adopt such amendments to the Plan and this Agreement or adopt other policies and procedures (including amendments, policies, and procedures with
retroactive effect), or take any other actions, that the Committee determines are necessary or appropriate to (a) exempt the SARs from Section 409A of the Code and/or preserve the intended tax treatment of the benefits provided with
respect to the SARs, or (b) comply with the requirements of Section 409A of the Code and related Department of Treasury guidance 
 17. Employee Data Privacy. As a condition of the grant of the SARs, the Participant consents to the collection, use and transfer of personal data as described in this paragraph. The Participant
understands that the Company and its Affiliates hold certain personal information about the Participant, including but not limited to the Participant’s name, home address and telephone number, date of birth, social security number, salary,
nationality, job title, shares of common stock or directorships held in the Company, details of all SARs or entitlement to shares of common stock awarded, cancelled, exercised, vested, unvested or outstanding in the Participant’s favor for the
purpose of managing and administering the Plan (“Data”). The Participant further understands that the Company and/or its Affiliates will transfer Data amongst themselves as necessary for the purposes of implementation, administration and
management of the Participant’s participation in the Plan, and that the Company and/or any of its Affiliates may each further transfer Data to any third parties assisting the Company in the implementation, administration and management of the
Plans. The Participant understands that these Participants may be located in the Participant’s country of residence or elsewhere. The Participant authorizes them to receive, possess, use, retain and transfer Data in electronic or other form,
for the purposes of implementing, administering and managing the Participant’s participation in the Plan, including any requisite transfer of such Data as may be required for the administration of the Plan. The Participant understands that the
Participant may, at any time, view the Data, require any necessary amendments to it or withdraw the consent herein in writing by contacting the local human resources representative. 

18. Confidentiality. The Participant agrees not to disclose the terms of this offer to anyone other than the members of the
Participant’s immediately family or the Participant’s counsel or financial advisors and agrees to advise such persons of the confidential nature of this offer. 
 19. Entire Agreement; Governing Law. The Plan is incorporated herein by reference. The Plan and this Agreement constitute the entire agreement of the parties with respect to the

  
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subject matter hereof and supersede in their entirety all prior undertakings and agreements of the Company and the Participant with respect to the subject matter hereof, and may not be modified
adversely to the Participant’s interest except by means of a writing signed by the Company and Participant. This Agreement is governed by the internal substantive laws but not the choice of law rules of North Carolina. 

 

							
	PARTICIPANT	 		 	QUINTILES TRANSNATIONAL HOLDINGS INC.
				
	  
	 		 	By:	 	  

	Signature	 		 	Name:	 	  

		 		 	Title:	 	  

  
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 Exhibit A 
 FORM OF 
 EXERCISE NOTICE FOR 2013 STOCK INCENTIVE PLAN 

Quintiles Transnational Holdings Inc. 
 4820
Emperor Blvd 
 Durham, NC 27703 

Attention: Stock Plan Administrator 
 1. Exercise of SARs. Effective as of today,                 , 20    , the undersigned (the
“Participant”) hereby elects to exercise the Participant’s stock appreciation rights with respect to              shares of the common stock (the “SARs”) of
Quintiles Transnational Holdings Inc. (the “Company”) under and pursuant to the Quintiles Transnational Holdings Inc. 2013 Stock Incentive Plan (the “Plan”) and the Award Agreement dated
                , 20     (the “Award”). 
 2. Tax Consultation and Withholding. The Participant understands that the Participant may suffer adverse tax consequences as a result of the Participant’s exercise of the SARs. The Participant
represents that the Participant has consulted with any tax consultants the Participant deems advisable in connection with the exercise of the SARs and that the Participant is not relying on the Company for any tax advice. The Participant further
understands that the Participant’s exercise of the SARs may give rise to an obligation on the part of the Company to withhold for income or other taxes due and agrees to make a payment to the Company in the amount necessary to allow the Company
to satisfy its withholding obligations. 
 3. Representations of Participant. The Participant acknowledges that the
Participant has received, read and understood the Plan and the Agreement and agrees to abide by and be bound by their terms and conditions. In making the decision to exercise the SARs the Participant has relied upon his or her own independent
investigations or those made by his or her representatives, if any (including professional, financial, tax, legal and other advisors). The Participant (and his or her representatives, if any) has had an opportunity to review information with respect
to the Company, desires no further additional information concerning the Company or its operations, and deems such information reviewed adequate to evaluate the merits and risks of the Participant’s exercise. 

4. Governing Law. This Agreement shall be governed by the internal substantive laws but not the choice of law rules of North
Carolina. 
 5. Entire Agreement. The Plan and Award are incorporated herein by reference. This Agreement, the Plan, and
the Award constitute the entire agreement of the parties with respect to the subject matter hereof and supersede in their entirety all prior undertakings and agreements of the Company and the Participant with respect to the subject matter hereof,
and may not be modified adversely to the Participant’s interest except by means of a writing signed by the Company and the Participant. 
 [signature page to Form of Exercise Notice to follow] 

 [signature page to Form of Exercise Notice] 

 

									
	Submitted by:	 		 	Accepted by:
			
	PARTICIPANT	 		 	QUINTILES TRANSNATIONAL HOLDINGS INC.
				
	  
	 		 	By:	 	  

	Signature	 		 	Name:	 	  

	Name:	 	  
	 		 	Title:	 	  

		 		 		 	Date:	 	  

  
 2

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