Document:

Amendment No. 3, dated October 8, 2010, to the Collaboration Agreement

 [ * ] = Certain confidential information contained in this document, marked by brackets, has been omitted
and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 
 Exhibit 10.39 
 AMENDMENT NO. 3
TO THE COLLABORATION AGREEMENT 
 BETWEEN 

EXELIXIS, INC., AND BRISTOL-MYERS SQUIBB
COMPANY 
  
  

THIS AMENDMENT NO. 3 (“Amendment No. 3”) to the Agreement
(defined below) is executed as of October 8, 2010 (the “Amendment No. 3 Execution Date”) by and between Exelixis, Inc., a Delaware corporation located at 170 Harbor Way, P.O. Box 511, South San Francisco, California
94083-0511 (“Exelixis”) and Bristol-Myers Squibb Company, a Delaware corporation headquartered at 345 Park Avenue, New York, New York 10154 (“BMS”). Exelixis and BMS may be referred to individually as a
“Party” and collectively as the “Parties”. 
 WHEREAS,
Exelixis and BMS entered into that certain Collaboration Agreement executed as of December 15, 2006, amended to be effective on January 11, 2007, and subsequently amended as of October 1, 2009 (the agreement and all such amendments,
collectively, the “Agreement”) for the purposes of applying Exelixis’ technology and expertise to the discovery, lead optimization and characterization of small molecule compounds that directly bind and modulate certain
oncology targets, with a goal of filing Investigational New Drug applications for such small molecule compounds, and to provide for the development and commercialization of novel therapeutic and prophylactic products based on such compounds; and

 WHEREAS, the Parties desire to amend the Agreement to enable Exelixis to opt-out of the development and
commercialization of the Collaboration Compound known as XL139, and to revise other provisions, as set forth below. 

NOW, THEREFORE, in consideration of the premises and mutual covenants herein
contained, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Parties hereto agree as follows: 
  

	1.	AMENDMENT OF THE AGREEMENT 

The Parties hereby agree to amend the terms of the Agreement as provided below, effective as of the Amendment No. 3 Effective Date.
To the extent that the Agreement is explicitly amended by this Amendment No. 3, the terms of this Amendment No. 3 will control where the terms of the Agreement are contrary to or conflict with the following provision. Where the Agreement
is not explicitly amended, the terms of the Agreement will remain in full force and effect. Capitalized terms used in this Amendment No. 3 that are not otherwise defined herein shall have the same meanings as such terms have in the Agreement.

 1.1 Exelixis Opt-Out of all SMO Products. The Parties agree that Exelixis hereby ceases its involvement in the
Development and Commercialization of all Products containing or 

 
comprising Collaboration Compounds directed against the SMO target, including without limitation the compound known as XL139 (such Collaboration Compounds, the “SMO Products”)
pursuant to a Product Opt-Out; therefore, the SMO Products are no longer Co-Developed Products and are now Royalty-Bearing Products. As of the Amendment No. 3 Effective Date, Exelixis shall have no further responsibility for conducting new
activities or funding new Development or Commercialization activities with respect to SMO Products. Furthermore, as of the Amendment No. 3 Effective Date, there are no ongoing Exelixis activities with respect to SMO Products. 

1.2 Economics Associated with the Opt-Out of the SMO Products. In consideration for Exelixis’ opt-out of SMO Products, BMS
agrees to the following: 
  

	 	(a)	BMS shall pay Exelixis a one-time fee of twenty million dollars ($20,000,000) within [ * ] after the Amendment No. 3 Effective Date. Such fee shall be
noncreditable and nonrefundable. 

  

	 	(b)	BMS’ obligation under Section 9.5(a) to pay Exelixis $20 million on the [ * ] is hereby cancelled. 

 

	 	(c)	BMS shall pay royalties to Exelixis on Net Sales (by BMS or its Affiliates or sublicensees) in the U.S. of Royalty-Bearing Products containing or comprising SMO
Products at the royalty rates described in Section 9.6(b)(i), i.e., rates of [ * ]%, [ * ]% and [ * ]%. 

 1.3 HSR Filing. The Parties acknowledge the need, pursuant to Section 13.6(b) of the Agreement, to make filings under the HSR Act in relation to Exelixis’ opting-out of the
Co-Development of SMO Products. Accordingly, the this Amendment No. 3 shall not become effective until the expiration or earlier termination of the waiting period under the HSR Act in the U.S., the expiration or earlier termination of any
applicable waiting period under the antitrust or competition laws of any other jurisdiction, and the approval or clearance of the transactions contemplated by this Agreement in any jurisdiction requiring advance approval or clearance (the
“Amendment No. 3 Effective Date”). 
 1.4 Amendment of the Research Term. The Parties agree to
delete Section 3.10 and replace it with the following. 
 “3.10 Research Term. The “Research
Term” shall commence on the Effective Date and continue until the Amendment No. 3 Effective Date. Following the end of the Research Term, Exelixis has no obligation to conduct any work under any Screening Programs, Lead Op Programs,
Provisional Collaboration Programs and Collaboration Programs (other than Exelixis’ responsibilities, as set forth in the remainder of this Agreement, with respect to Co-Developed Products and Backup Programs for Collaboration Targets), and all
rights with respect to Lead Op 

  
 [ * ] = Certain
confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

  
 2 

 
Candidates, Lead Op Targets and Collaboration Compounds, other than Collaboration Compounds included in a Collaboration Program for which BMS has exercised its Co-Development Option under
Section 3.4, and in any case subject to Section 3.8(e), automatically and immediately revert to Exelixis.” 
 1.5 Amendment of Patent Prosecution. The Parties agree to delete Section 10.3(b) and replace it with the following. 

“10.3(b) Joint Patent Committee. 
 (i) Establishment & Meetings. Promptly after the Amendment No. 3 Effective Date, the Parties shall establish a committee (the “Joint Patent Committee” or
“JPC”). The JPC shall be composed of at least one (1) representative from each Party, at least one of which shall be a patent counsel for such Party. Each Party may change its representative(s) by giving the other Party at
least [ * ] prior written notice. The JPC shall meet within [ * ] after the Amendment No. 3 Effective Date, and once per [ * ] thereafter, or as may be requested by either Party as necessary, by teleconference, videoconference or in person (as
determined by the JPC). 
 (1) Duties. Promptly after the Amendment No. 3 Effective Date, [ * ] shall oversee
(subject to Sections 10.3(b)(ii), (iv) and (v) below) the preparation, filing, prosecution (including any interferences, reissue proceedings and reexaminations) and maintenance of all [ * ] Patents, [ * ] Patents Controlled
by [ * ], and [ * ] Patents that in each case are [ * ] (the “[ * ] Patents”), provided that, unless otherwise agreed by the Parties, such responsibilities shall be carried out by: (A) [ * ] by [ * ] the [ * ], unless there
exists [ * ] of [ * ] and [ * ]; (B) [ * ] by [ * ], but only in the case where [ * ] described in subsection (A) had [ * ] of [ * ]; or (C) [ * ] in conjunction with [ * ] described in the preceding subsection (A) or (B), as
applicable. [ * ], or [ * ], shall provide [ * ] with an update of the filing, prosecution and maintenance status for each of the [ * ] Patents on a periodic basis, and shall use commercially reasonable efforts to consult with and cooperate with [ *
] with respect to the filing, prosecution and maintenance of the [ * ] Patents, including providing [ * ] with drafts of proposed filings to allow [ * ] a reasonable opportunity for review and comment before such filings are due. [ * ], or [ * ],
shall provide to [ * ] copies of any papers relating to the filing, prosecution and maintenance of the [ * ] Patents promptly upon their being filed and received. 
 (2) Decisions. Subsequent to the Amendment No. 3 Effective Date, in the event of a dispute between the Parties with regard to the preparation, filing, prosecution (including any interferences,
reissue proceedings and reexaminations) and maintenance of any [ * ] Patent, the matter shall be promptly referred to the [ * ] and [ * ] for BMS. If these two (2) individuals are unable to resolve the dispute promptly, then the matter shall be
promptly elevated to the [ * ] of Exelixis and the [ * ] of BMS. If these two (2) individuals are unable to resolve the dispute promptly, then, subject to Sections 10.3(b)(i)(3), 10.3(b)(i)(4), 10.3(b)(ii), [ * ] of the ROR Collaboration
Agreement, and [ * ] of the ROR 

  
 [ * ] = Certain
confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

  
 3 

 
Collaboration Agreement, BMS shall have the final decision, except if such decision: (A) conflicts with the terms of the Agreement; (B) would result in [ * ] described in
Section [ * ] or a [ * ] of the [ * ]; or (C) materially impacts [ * ] prosecution of Patents that [ * ] a [ * ], in which case of subsection 10.3(b)(i)(2)(A) - (C), [ * ] shall have the final decision 

(3) Limitation on Subsection 10.3(b)(i)(2)(B). If [ * ] reasonably believes that filing a new patent application covering a [ * ]
(other than the [ * ] of a [ * ]) would result in potential claims [ * ] for [ * ], and if [ * ] disputes with [ * ] that such patent application should be filed, then such dispute shall be discussed as described in the first two (2) sentences
of Section 10.3(b)(i)(2), and, if still unresolved, shall be arbitrated pursuant to Section [ * ] of the ROR Collaboration Agreement, and [ * ] shall not have the right to exercise its final-decision making authority pursuant to
Subsection 10.3(b)(i)(2)(B) unless the dispute is resolved in [ * ] favor. 
 (4) Limitation on Subsection
10.3(b)(i)(2)(C). [ * ] hereby covenants that it shall not, without the prior written consent of [ * ] (which shall not be unreasonably delayed or conditioned), during the term of this Agreement, [ * ] the decision-making authority granted to [
* ] pursuant to Subsection 10.3(b)(i)(2)(C) [ * ] that is [ * ] existing as of the Effective Date or [ * ]. Furthermore, if [ * ] the decision-making authority granted to [ * ] pursuant to Subsection 10.3(b)(i)(2)(C) [ * ] by [ * ], [
* ] or [ * ], and such [ * ] is [ * ] or [ * ] a [ * ] that is [ * ], then [ * ] and [ * ] shall agree, pursuant to Section [ * ] of the ROR Collaboration Agreement, on [ * ] the decision-making authority granted to [ * ] pursuant to
Subsection 10.3(b)(i)(2)(C). 
 (ii) Abandonment. In no event shall [ * ] knowingly permit any of the [ *
] Patents to be abandoned in any country, or elect not to file a new patent application claiming priority to a patent application within the [ * ] Patents either before such patent application’s issuance or within the time period required for
the filing of an international (i.e., Patent Cooperation Treaty), regional (including European Patent Office) or national application, without [ * ] written consent (such consent not to be unreasonably withheld, delayed or conditioned) or [ * ]
otherwise first being given an opportunity to assume full responsibility (at [ * ] expense) for the continued prosecution and maintenance of such [ * ] Patents or the filing of such new patent application. Accordingly, [ * ], or [ * ], shall provide
[ * ] with notice of the allowance and expected issuance date of any patent within the [ * ] Patents, or any of the aforementioned filing deadlines, and [ * ] shall provide [ * ] with prompt notice as to whether [ * ] desires [ * ] to file such new
patent application. In the event that [ * ] decides either: (A) not to continue the prosecution or maintenance of a patent application or patent within the [ * ] Patents in any country; or (B) not to file such new patent application
requested to be filed by [ * ], [ * ] shall provide [ * ] with notice of this decision at least [ * ] prior to any pending lapse or abandonment thereof, and [ * ] shall thereafter have the right to assume responsibility for the filing, prosecution
and maintenance of such patent or patent application. In the event that [ * ] assumes such responsibility for such filing, prosecution and maintenance, [ * ] shall no longer have the responsibility for such filing, prosecution and maintenance of
such patent applications and 

  
 [ * ] = Certain
confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

  
 4 

 
patents, and [ * ] shall cooperate as reasonably requested by [ * ] to facilitate control of such filing, prosecution and maintenance by [ * ]. In the case where [ * ] takes over the filing,
prosecution or maintenance of any patent or patent application as set forth above, such patent or patent application shall [ * ] be [ * ] the [ * ], and [ * ] shall [ * ] such patent or patent application. 

(iii) Filing, Prosecution and Maintenance of Sole Invention Patents Controlled by BMS. In accordance with this
Section 10.3 (a)(iii), BMS shall be responsible for the filing, prosecution (including any interferences, reissues and reexaminations) and maintenance of all Sole Invention Patents Controlled by BMS. BMS shall provide to Exelixis copies
of any papers relating to the filing, prosecution and maintenance of the Sole Invention Patents Controlled by BMS promptly upon their being filed and received. 
 (iv) Patent Term Extension. Exelixis and BMS shall each cooperate with each another and shall use commercially reasonable efforts in obtaining patent term extension (including any pediatric
exclusivity extensions as may be available) or supplemental protection certificates or their equivalents in any country with respect to patent rights covering the Products. If elections with respect to obtaining such patent term extensions are to be
made, [ * ] shall have the right to make the election to seek patent term extension or supplemental protection. 
 (v)
Exelixis Right to Separate Claims. To the extent that any Sole Invention Patent of Exelixis contains claims that cover compounds that are not Collaboration Compounds (such compounds, “Separable Compounds”), Exelixis shall have
the right to separate any claims that cover such Separable Compounds (and not Collaboration Compounds) and to file such claims in a separate application (e.g., a continuation, continuation-in-part, or divisional application). Exelixis shall notify
BMS in writing prior to separating such claims, and such separation shall be at Exelixis’ sole expense.” 
 1.6 Amendment of the Entire Agreements Provision. The Parties agree to delete Section 15.4 and replace it with the following. 

“15.4 Entire Agreement; Amendments. This Agreement, the collaboration agreement (for the discovery, development and
commercialization of compounds that antagonize the target known as ROR) that is between Exelixis and BMS and that is dated as of the Amendment No. 3 Execution Date (the “ROR Collaboration Agreement”), and the letter agreement
that is dated as of the Amendment No. 3 Execution Date and that describes Exelixis’ creation of a licensing Affiliate (the “Letter Agreement”), set forth the complete, final and exclusive agreement and all the covenants,
promises, agreements, warranties, representations, conditions and understandings between the Parties hereto and supersedes and terminates all prior agreements and understandings between the 

  
 [ * ] = Certain
confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

  
 5 

 
Parties. There are no covenants, promises, agreements, warranties, representations, conditions or understandings, either oral or written, between the Parties other than as are set forth in this
Agreement, the ROR Collaboration Agreement, and the Letter Agreement. No subsequent alteration, amendment, change or addition to this Agreement shall be binding upon the Parties unless reduced to writing and signed by an authorized officer of each
Party.” 
  

	2.	MISCELLANEOUS 

 2.1 Full Force and Effect. This Amendment No. 3 amends the terms of the Agreement and is deemed incorporated into, and governed by all other terms of, the Agreement. The provisions of the
Agreement, as amended by this Amendment No. 3, remain in full force and effect. 
 2.2 Further Actions. Each Party
shall execute, acknowledge and deliver such further instruments, and do all other acts, as may be necessary or appropriate in order to carry out the purposes and intent of this Amendment No. 3. 

2.3 Counterparts. This Amendment No. 3 may be executed in two (2) or more counterparts, each of which shall be an
original and all of which shall constitute together the same document. Counterparts may be signed and delivered by facsimile, or electronically in PDF format, each of which shall be binding when sent. 

Signature page follows 

  
 [ * ] = Certain
confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

  
 6 

 IN WITNESS WHEREOF, the Parties have
caused this Amendment No. 3 to be executed by their duly authorized representatives. The date that this Amendment No. 3 is signed shall not be construed to imply that the document was made effective on that date. 

 

									
	Bristol-Myers Squibb Company	 		 	Exelixis, Inc.
					
	Signature:	 	             /s/ Jeremy
Levin
	 		 	Signature:	 	             /s/ Michael
Morrissey

									
					
	Name:	 	
                    
Jeremy Levin
	 		 	Name:	 	
                    
Michael Morrissey

									
					
	Title:	 	     Senior Vice President
	 		 	Title: 	 	
                    
CEO

					
	Date:	 	
                    
10/08/2010
	 		 	Date:	 	
                    
10/08/2010

  
 [ * ] = Certain
confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

  
 7Third Amendment to Lease dated May 24, 2001

 Exhibit 10.46 
 THIRD AMENDMENT TO BUILD-TO-SUIT LEASE 
 This Third Amendment to
Build-to-Suit Lease (“Third Amendment”) is made and entered into as of May 24, 2001, by and between BRITANNIA POINTE GRAND LIMITED PARTNERSHIP, a Delaware limited partnership (“Landlord”), and
EXELIXIS, INC. (formerly known as Exelixis Pharmaceuticals, Inc.), a Delaware corporation (“Tenant”), with reference to the following facts: 
 A. Landlord and Tenant are parties to a Build-to-Suit Lease dated as of May 12, 1999, as amended by a First Amendment to Build-to-Suit Lease dated as of March 29, 2000 and by a Second Amendment
to Build-to-Suit Lease dated as of January 31, 2001 (collectively, as so amended, the “Existing Lease”), covering buildings occupied by Tenant at 169 Harbor Way and 170 Harbor Way, South San Francisco, California and an
elevated connector bridge between those two buildings across Harbor Way. Terms used in this Third Amendment as defined terms but not defined herein shall have the meanings assigned to such terms in the Lease. 

B. Landlord and Tenant are also executing, substantially concurrently with this Third Amendment, a Lease of even date herewith (the
“New Lease”) covering the building presently occupied by Rigel Pharmaceuticals, Inc. at 240 East Grand Avenue, South San Francisco, California, which building is to be occupied by Tenant in the future at the time and under the conditions
set forth in the New Lease. 
 C. The New Lease includes a “cross-default” provision providing, in substance, that any
uncured default under the Existing Lease shall also constitute a default under the New Lease. By this Third Amendment, the parties wish to insert a reciprocal “cross-default” provision in the Existing Lease, as hereinafter set forth.

 NOW, THEREFORE, in reliance upon the foregoing recitals and upon the mutual agreements set forth herein and for other good
and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant agree as follows: 

1. Addition of Cross-Default Provision. Section 16.1 of the Existing Lease is amended by adding, at the end thereof, the
following paragraph as an additional matter constituting an event of default on the part of Tenant under the Existing Lease: 

“(i) Cross-Default. Any default by Tenant under the New Lease (as defined in the Third Amendment to this Lease), to the
extent such default continues beyond any applicable cure period provided in the New Lease and to the extent Landlord therefore has (and exercises concurrently with any termination of this Lease) a right to terminate the New Lease; provided,
however, that the default event set forth in this Section 16.1(i) shall not apply with respect to any default by Tenant under the New Lease if, at the time of such default, any of the following conditions exists: (A) the holder of the
landlord’s interest under the New Lease is neither the person or entity which is then the holder of the landlord’s interest under this Lease nor a person or entity which controls, is controlled by or is under common control with the person
or entity which is then the holder of the landlord’s interest under this Lease; (B) the holder of the tenant’s interest under the New Lease is neither the person or entity which is then the holder of the

 
tenant’s interest under this Lease nor a person or entity which controls, is controlled by or is under common control with the person or entity which is then the holder of the tenant’s
interest under this Lease; or (C) either the Property under this Lease or the property subject to the New Lease is subject to one or more outstanding mortgages or deeds of trust, and the other such property is either not subject to any
outstanding mortgage or deed or trust, or is subject to one or more outstanding mortgages or deeds of trust and the beneficial interest under at least one such mortgage or deed of trust on such other property is held by a person or entity as lender
which is neither the holder of the beneficial interest under any of the outstanding mortgages or deeds or trust on the first such property nor a person or entity which controls, is controlled by or is under common control with the holder of the
beneficial interest under any of the outstanding mortgages or deeds of trust on the first such property.” 
 2. Entire
Agreement. The Lease, as amended by this Third Amendment, contains all the representations and the entire understanding between the parties with respect to the subject matter of this Third Amendment. Any prior correspondence, memoranda or
agreements are replaced in total by this Third Amendment and the Lease as amended hereby. 
 3. Execution and Delivery.
This Third Amendment may be executed in one or more counterparts and by separate parties on separate counterparts, but each such counterpart shall constitute an original and all such counterparts together shall constitute one and the same
instrument. 
 4. Full Force and Effect. Except as expressly set forth herein, the Lease has not been modified or amended
and remains in full force and effect. 
 IN WITNESS WHEREOF, the parties hereto have extended this Third Amendment as of the
date first set forth above. 
  

													
	 “Landlord”
	 		 	 “Tenant”

		
	 BRITANIA POINTE GRAND LIMITED
 PARTNERSHIP, a Delaware limited
 partnership
	 	EXELIXIS, INC., a Delaware corporation
		 		 		 		 	By:	 	 /S/ George A. Scangos

	By:	 	BRITANIA POINTE GRAND, LLC, a California limited liability company, General Partner	 		 		 	 George A. Scangos

President and CEO

						
		 	By:	 	 /s/ T.J. Bristow
	 		 	 By:	 	 /s/ Glen Sato 

		 		 	 T.J. Bristow
 Its Manager,
President and
 Chief Financial Officer
	 		 	 Its:	 	 CFO

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00184-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00184-of-00352.parquet"}]]