Document:

<Page>

                        SECOND AMENDMENT AND WAIVER DATED
                              AS OF JUNE 25, 2001
                          TO REVOLVING CREDIT AGREEMENT
                            DATED AS OF JUNE 26, 2000

    THIS SECOND AMENDMENT AND WAIVER (this "AMENDMENT"), dated as of June 25,
2001, is entered into between FIRST COMMUNITY BANCORP, a California
corporation (the "BORROWER"), and THE NORTHERN TRUST COMPANY, an Illinois
banking corporation having its principal office at 50 South LaSalle Street,
Chicago, Illinois  60675 (the "LENDER").

                                    RECITALS:

    A.  The Borrower and the Lender have entered into a Revolving Credit
Agreement dated as of June 26, 2000, as amended by the First Amendment dated
as of January 12, 2001 (said Revolving Credit Agreement, as so amended, shall
hereinafter be referred to as the "Agreement"; the terms defined in the
Agreement and not otherwise defined herein shall be used herein as defined in
the Agreement).

    B.  The Borrower and the Lender wish to (i) amend the Agreement to (a)
extend the Maturity Date, (b) amend certain financial covenants and (c) to
otherwise amend certain provisions of the Agreement; and (ii) waive certain
Events of Default due to non-compliance with certain financial covenants.

    C.  Therefore, the parties hereto agree as follows:

1.  AMENDMENTS TO THE AGREEMENT.

        1.1.  SECTION 1.1 OF THE AGREEMENT.  SECTION 1.1 of the Agreement is
hereby amended as of the date hereof by deleting the date "June 25, 2001"
appearing therein and substituting the date "June 24, 2002" therefor.

        1.2.  SECTION 5.4(d) OF THE AGREEMENT.  SECTION 5.4(d) of the
Agreement is hereby deleted in its entirety as of the date hereof and the
following substituted therefor:

    "(d)  NONPERFORMING ASSETS.  All assets of all Subsidiary Banks and other
    Subsidiaries classified as "non-performing" (which shall include all loans
    in non-accrual status, more than ninety (90) days past due in principal or
    interest, restructured or renegotiated, or listed as "other restructured"
    or "other real estate owned") on the FDIC or other regulatory agency call
    report shall not exceed at any time three and one-half percent (3.5%)
    through and including December 31, 2001, and three percent (3.0%)
    thereafter, of the total loans of the Borrower and its Subsidiaries, all
    calculated on a consolidated basis."

        1.3.  SECTION 5.4(e) OF THE AGREEMENT.  SECTION 5.4(e) of the
Agreement is hereby deleted in its entirety as of the date hereof and the
following substituted therefor:

<Page>

        "(e)  LOAN LOSS RESERVE RATIO.  Borrower shall maintain at all times
    on a consolidated basis a ratio of loan loss reserves to non-performing
    loans of not less than seventy-five percent (75%)."

        1.4.  SECTION 5.4(f) OF THE AGREEMENT.  Section 5.4(f) of the
Agreement is hereby deleted in its entirety as of the date hereof and the
following substituted therefor:

        "(f)  MINIMUM TANGIBLE NET WORTH.  Borrower shall maintain a
consolidated minimum Tangible Net Worth equal to at least $36,000,000 at all
times."

2.  WAIVER.  The Borrower has advised the Lender that it has not been in
compliance with SECTION 5.4(e) (Loan Loss Reserve Ratio) of the Agreement for
its fiscal quarter ended March 31, 2001.  On the date hereof, as of and
through March 31, 2001, the Lender waives compliance by the Borrower with
SECTION 5.4(e).  The Lender's waiver of non-compliance with SECTION 5.4(e) of
the Agreement is limited to the specific instance of failure to comply which
is described above and shall not be deemed a waiver of or consent to any
other failure to comply with the terms of SECTION 5.4(e) of the Agreement or
any other provisions of the Agreement.  Such wavier shall not prejudice or
constitute a waiver of any right or remedies which the Lender may have or be
entitled to with respect to any other breach of SECTION 5.4(e) or any other
provision of the Agreement.

3.  WARRANTIES.  To induce the Lender to enter into this Amendment, the
Borrower warrants that:

        3.1.  AUTHORIZATION.  The Borrower is duly authorized to execute and
deliver this Amendment and is and will continue to be duly authorized to
borrow monies under the Agreement, as amended hereby, and to perform its
obligations under the Agreement, as amended hereby, the Pledge Agreement and
the Note.

        3.2.  NO CONFLICTS.  The execution and delivery of this Amendment,
and the performance by the Borrower of its obligations under the Agreement,
as amended hereby, the Pledge Agreement and the Note, do not and will not
conflict with any provision of law or of the charter or by-laws of the
Borrower or of any agreement binding upon the Borrower.

        3.3.  VALIDITY AND BINDING EFFECT.  The Agreement, as amended hereby,
the Pledge Agreement and the Note are legal, valid and binding obligations of
the Borrower, enforceable against the Borrower in accordance with their
terms, except as enforceability may be limited by bankruptcy, insolvency or
other similar laws of general application affecting the enforcement of
creditors' rights or by general principles of equity limiting the
availability of equitable remedies.

4.  CONDITIONS PRECEDENT TO AMENDMENTS.  The amendments contemplated by
SECTION 1 and the waiver contemplated by Section 2 hereof are subject to the
satisfaction of each of the following conditions precedent:

                                       2
<Page>

        4.1.  DOCUMENTATION.  The Borrower shall have delivered to the Lender
all of the following, each duly executed and dated the date hereof or other
date satisfactory to the Lender, in form and substance satisfactory to the
Lender:

        (a)  AMENDMENT.  A counterpart of this Amendment.

        (b)  RESOLUTIONS.  A copy, duly certified by the secretary or an
assistant secretary of the Borrower, of (i) resolutions of the Borrower's
Board of Directors authorizing or ratifying the execution and delivery of
this Amendment and authorizing the borrowings under the Agreement, as amended
hereby; (ii) all documents evidencing other necessary corporate action; (iii)
all approvals or consents, if any, with respect to this Amendment; and (iv)
any and all amendments and modifications to the articles of incorporation and
by-laws of the Borrower since June 26, 2000, the date that such articles and
by-laws were delivered to the Lender, or, if applicable, certification by
said secretary or assistant secretary that there have been no amendments or
modifications to the articles of incorporation and the by-laws of Borrower
since June 26, 2000 and they are in full force and effect.

        (c)  INCUMBENCY CERTIFICATE.  A certificate of the secretary or an
assistant secretary of the Borrower certifying the names of the Borrower's
officers authorized to sign this Amendment and all other documents or
certificates to be delivered hereunder, together with the true signatures of
such officers.

        (d)  OPINION.   An opinion of counsel to the Borrower, addressed to
the Lender, in substantially the form of EXHIBIT A hereto.

        (e)  CERTIFICATE.  A certificate of the president or chief financial
officer of the Borrower as to the matters set out in SECTIONS 4.2 and 4.3
hereof.

        (f)  OTHER.  Such other documents as the Lender may reasonably
request.

        4.2.  NO DEFAULT.  After giving effect to the waiver herein, no Event
of Default or Unmatured Event of Default under the Agreement shall have
occurred and be continuing.

        4.3.  WARRANTIES.  After giving effect to the waiver herein, the
warranties in SECTION 4 of the Agreement and in SECTION 3 of this Amendment
shall be true and correct as though made on such date, except for such
changes as are specifically permitted under the Agreement.

5.  GENERAL.

        5.1.  EXPENSES.  The Borrower agrees to pay the Lender upon demand
for all reasonable expenses, including reasonable attorneys' and legal
assistants' fees (which attorneys and legal assistants may be employees of
the Lender), incurred by the Lender in connection with the preparation,
negotiation and execution of this Amendment and any document required to be
furnished therewith.

                                       3
<Page>

        5.2.  LAW.  THIS AMENDMENT SHALL BE CONSTRUED IN ACCORDANCE WITH AND
GOVERNED BY THE INTERNAL LAWS OF THE STATE OF ILLINOIS.

        5.3.  SUCCESSORS.  This Amendment shall be binding upon the Borrower
and the Lender and their respective successors and assigns, and shall inure
to the benefit of the Borrower and the Lender and the successors and assigns
of the Lender.

        5.4.  CONFIRMATION OF THE AGREEMENT.  The Agreement, as amended
hereby, the Note and the Pledge Agreement shall remain in full force and
effect and is hereby ratified and confirmed in all respects.

        5.5.  REFERENCES TO THE AGREEMENT.  Each reference in the Agreement
to "this Agreement," "hereunder," "hereof," or words of similar import in
instruments or documents provided for in the Agreement or delivered or to be
delivered thereunder or in connection therewith, shall, except where the
context otherwise requires, be deemed, respectively, a reference to the
Agreement, as amended hereby.

        5.6.  COUNTERPARTS.  This Amendment may be executed in any number of
counterparts, each of which shall be deemed to be an original and all of
which, taken together, shall constitute but one and the same Amendment.

                          [SIGNATURE PAGE FOLLOWS.]

                                       4
<Page>

    IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be
executed at Chicago, Illinois by their respective officers thereunto duly
authorized as of the date first written above.

                                       FIRST COMMUNITY BANCORP

                                       By:
                                           -----------------------------------

                                       Title
                                             ---------------------------------

                                       THE NORTHERN TRUST COMPANY

                                       By:
                                           -----------------------------------
                                       Name:  Thomas E. Bernhardt

                                       Title Vice President

                                       5<PAGE>

                                                                     Exhibit 4.1

                                                                  EXECUTION COPY

                   AMENDMENT NO. 1 TO THE AMENDED AND RESTATED
                              INVESTORS' AGREEMENT

         AMENDMENT NO. 1 dated as of June 15, 2001 to the Amended and Restated
Investors' Agreement dated as of June 19, 2000, as amended (the "INVESTORS'
AGREEMENT").

                              W I T N E S S E T H:

         WHEREAS, Charles River Laboratories International, Inc., a Delaware
corporation (the "COMPANY"), and several stockholders from time to time parties
thereto (the "STOCKHOLDERS") have entered into the Investors' Agreement;

         WHEREAS, in order to change the notice provision to the Stockholders in
connection with their Registration Rights; and

         WHEREAS, in order to permit other stockholders, not party to the
Investors' Agreement, to exercise their registration rights, the Company, DLJ
Merchant Banking II, Inc. and B&L CRL, Inc. desire to amend the Investors'
Agreement as provided hereunder in accordance with Section 6.06 thereof.

         NOW, THEREFORE, it is agreed as follows:

         SECTION 1. DEFINED TERMS; REFERENCES. Unless otherwise specifically
defined herein, each term used herein which is defined in the Investors'
Agreement has the meaning assigned to such term in the Investors' Agreement.
Each reference to "hereof," "hereunder," "herein" and "hereby" and each other
similar reference and each reference to "this Agreement" and each other similar
reference contained in the Investors' Agreement shall, after this Amendment
becomes effective, refer to the Investors' Agreement as amended hereby.

         SECTION 2.  AMENDMENT TO SECTION 5.01 OF THE INVESTORS' AGREEMENT.

         (a) Section 5.01(a) is hereby amended by replacing "at least 30 days
prior to the anticipated filing" with "at least 2 days after the filing".

         (b) Section 5.01(a)(ii) is hereby amended by replacing "within 15 days
after receipt" with "within 5 days after receipt", and by adding the phrase "and
any other stockholder (not party to this Agreement) entitled to registration
rights" after the parenthetical which defines "Holders" and after the term
"Holders".

<PAGE>

         (c) Section 5.01(b) is hereby amended by replacing "the 15-day period"
in the first sentence with "the 5-day period".

         (d) Section 5.01(e) is hereby amended by adding the following paragraph
(E):

                  "(E) fifth: any securities proposed to be registered by any
         other stockholders, not subject to this Agreement, that have
         registration rights (allocated, if necessary for the offering not to
         exceed the Maximum Offering Size, pro rata among such other
         stockholders on the basis of the relative number of shares of
         securities requested to be included in such registration)."

         SECTION 3. AMENDMENT TO SECTION 5.02 OF THE INVESTORS' AGREEMENT.

         (a) Section 5.02(a) of the Investors' Agreement is hereby amended by
replacing "at least 30 days prior to the anticipated filing" with "at least 2
days after the filing", by replacing "within 15 days after receipt" with
"within 5 days after receipt", and by adding the following sentence after the
definition of Incidental Rights:

         "; PROVIDED that such Incidental Registration rights do not apply to a
registration pursuant to Section 6.4(b) of the Stock Purchase Agreement by and
among Charles River Laboratories, Inc., Primedica Corporation, TSI Corporation
and Genzyme Transgenics Corporations ("Genzyme"), dated February 6, 2001, as
amended from time to time ( the "Primedica Purchase Agreement")".

         (b) Section 5.02(b)(ii) of the Investors' Agreement is hereby amended
and restated in its entirety to read as follows:

                           (ii) second, all Registrable Securities requested to
                  be included in such registration by the DLJMB Entities and
                  their Permitted Transferees, or any Other Stockholder pursuant
                  to this Section 5.02 and any other stockholder entitled to
                  registration rights requested to be included (allocated if
                  necessary for the offering not to exceed the Maximum Offering
                  Size, pro rata among such Stockholders and any other
                  stockholders, not party to this Agreement, on the basis of the
                  relative number of shares of Registrable Securities so
                  requested to be included in such registration); PROVIDED that
                  the Company may permit Genzyme to sell more than its pro rata
                  amount up to 658,945 shares of the Company's common stock
                  which Genzyme received pursuant to the Primedica Purchase
                  Agreement.

                                       2
<PAGE>

         SECTION 4. GOVERNING LAW. THIS AMENDMENT SHALL BE GOVERNED BY AND
CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF DELAWARE WITHOUT REGARD TO
THE CONFLICTS OF LAW RULES OF SUCH STATE.

         SECTION 5. EFFECTIVENESS. This Amendment will be effective as of the
date hereof when signed by the Company, DLJ Merchant Banking II, Inc. and B&L
CRL, Inc.

                                       3
<PAGE>

         IN WITNESS WHEREOF, the undersigned have executed this Amendment as of
the 15th day of June 2001.

                                             Charles River Laboratories,
                                             International, Inc.

                                             By:
                                                ------------------------
                                                Name:
                                                Title:

                                             DLJ Merchant Banking II, Inc.

                                             By:
                                                ------------------------
                                                Name:
                                                Title:

                                             B&L CRL, Inc.

                                             By:
                                                ------------------------
                                                Name:
                                                Title:

                                       4

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00028-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00028-of-00352.parquet"}]]