Document:

Consulting Agreement between Insert Therapeutics and Neologix, Inc.

 Exhibit 10.9 
  
 CONSULTING SERVICES AGREEMENT 
  
 This Consulting Services Agreement is made July 1, 2002, between
INSERT THERAPEUTICS, INC., a Delaware corporation, located at 2585 Nina Street, Pasadena, CA 91107 (“Company”), and NEOLOGIX, a California corporation
located at the address set forth in Attachment 1 hereto (“Consultant”). The “Standard Terms and Conditions” attached hereto are incorporated herein by this reference as if fully set forth. 
  
 INITIAL PROJECT SCHEDULE

  

	1.	Services to be Provided 

  
 The “Services,” as that term is used in the Agreement, will include strategic business advice across a wide range of areas, and may include, by
way of example, the following: 
  

	 	•	Manage the relationship with outside legal counsel. 

  

	 	•	Identify and manage relationship with investment bankers, venture capital sources and financial Consultants. 

  

	 	•	Manage relations and communications with shareholders. 

  

	 	•	Structure and assist in documenting various corporate development transactions, strategic relationships, joint ventures, partnerships and financing transactions, together with the
Company’s outside legal counsel. 

  

	 	•	Prepare a business plan, executive summary, financial projections, and offer other assistance in identifying fundraising opportunities. 

  

	 	•	Prepare, negotiate and review documents with the assistance of the Company’s outside legal counsel. 

  

	 	•	Participate, as requested, in strategic management discussions and decision-making. 

  

	 	•	Participate in staff meetings. 

  

	 	•	Manage Board of Directors meetings, agenda and materials. 

  

	 	•	Other services as requested by the CEO and other members of senior management. 

  

The Services will be rendered when and as requested by the Company. 
  
 ALTHOUGH CERTAIN ASPECTS OF THE
SERVICES WILL INVOLVE THE PREPARATION AND REVIEW OF LEGAL DOCUMENTATION AND
LEGAL ISSUES, THE SERVICES ARE NOT AND DO NOT CONSTITUTE LEGAL
SERVICES OR LEGAL REPRESENTATION; SEE SECTION 1 OF “STANDARD TERMS AND
CONDITIONS”. 

	2.	Compensation. 

  
 Provided that Consultant is not in breach or default hereunder, as full compensation for all services rendered hereunder, the Work and any and all rights
granted or assigned to Company by Consultant under this Agreement, Consultant shall receive the following: 
  
 Consulting Services: Services will be billed by the hour, in 15 minute increments, in accordance with the following schedule: 
  
 First 10 hours in any calendar
month:            $150/hour 
 Next 15 hours in any calendar
month:            $125/hour 
 Hours in excess of 25 hours per
month:         $100/hour 
  

	3.	Deliverables. 

  
 As directed by the Company in connection with any request for Services. 
  

	4.	Expenses. 

  
 Company will reimburse Consultant for all reasonable, actual and necessary expenses incurred in the establishment and performance of this Agreement,
including without limitation accounting, legal, telephone, fax, postage, business meals and entertainment, courier (including deliverables to Company required under this Agreement), photocopying, and the use of a personal automobile which will be
billed at the approved IRS rate per mile. Company will also reimburse Consultant for travel in the performance of this Agreement when authorized in advance. Reimbursement will be for airfare, lodging, baggage handling, reasonable and actual expenses
for meals, transportation (car rental, taxi, etc.) and the like while traveling in connection with the services rendered hereunder. All reimbursements will be made within thirty (30) days after receipt by Company of an itemized invoice supported by
receipts. 
  

	5.	Other Agreements. 

  
 None 
  

	6.	Designated Persons. 

  
 The person(s) whose signatures appear below under the heading “Designated Person(s)” are employees of Consultant, and shall be deemed to be
“Designated Persons” for the purpose of the Agreement and the Initial Project Schedule or any subsequent Project Schedules.  
  

			
	INSERT THERAPEUTICS, INC.,
	a Delaware corporation
		
	By:	 	 /s/ Gary Lazar

	 	 	President
	
	NEOLOGIX,
	a California corporation
		
	By:	 	 John G. Petrovich

	 	 	President

  

 2 

 DESIGNATED PERSON(S): 
  
 I hereby acknowledge and agree with the foregoing, insofar as my personal services are to be provided under the Consulting Agreement. I further specifically agree to be
bound by Sections 5, 6, 7 and 8 of the Consulting Agreement. 
  

	
	 /s/ John G. Petrovich

	 John G. Petrovich

  

 3 

 ATTACHMENT 1 
 INDEPENDENT CONSULTANT INFORMATION FORM 
  
 In order to comply with the rules & regulations of the State and Federal Government, persons rendering services as Independent Consultants must meet the following criteria: 
  

	1)	Engaged in a distinct occupation or business; 

	2)	Perform services without direct supervision; 

	3)	Provide tools & equipment for said services; and 

	4)	Provide business license, and/or Federal I.D. number, or valid Social Security Number. 

  
 An Independent Consultant is required to report his/her annual income received (if over SIX HUNDRED AND 00/100 DOLLARS
($600.00)) via a Form 1099. In order to comply with this regulation, please provide the following information: 
  

			
	NAME:	 	Neologix
	ADDRESS:	 	173 Highland Place
	 	 	Monrovia, CA 91016
	PHONE NO:	 	818.419.7598
	FAX NO:	 	253.669.2568
	FEDERAL TAX I.D. NO:	 	95-4862505

  
 I certify that I meet the above
criteria, that the information provided above is true and that I will promptly notify the Company, in writing, of any changes to the above, as set forth in that certain Consulting Services Agreement, dated as of June 1, 2002, to which this is an
attachment. 
  

			
	NEOLOGIX, a California corporation
		
	By:	 	 /s/ John G. Petrovich

	 	 	John G Petrovich, President

  
 DATE: June 1, 2002 
  
 Attachment 1 

 STANDARD TERMS AND CONDITIONS

  
 In consideration of the mutual covenants herein contained,
the parties hereby agree to the following Standard Terms and Conditions, which are incorporated into the Agreement to which they are attached: 
  
 1. Services. Consultant agrees to provide the services specified in any Project Schedule that shall, from time to time, be defined and executed by
the parties and attached to this Agreement. The initial Project Schedule is the first page of the Agreement to which these Standard Terms and Conditions are attached. Subsequent Project Schedules, substantially in the same form as the first page of
the Agreement to which these Standard Terms and Conditions are attached, shall be prepared and signed by the parties as necessary and attached to this Agreement and these Standard Terms and Conditions, which will be deemed to be incorporated by
reference into said Project Schedule. Such services are hereinafter referred to as “Services.” Consultant agrees to provide the Services only and exclusively by and through the person or persons Consultant has designated on any Project
Schedule (each, a “Designated Person” and collectively, “Designated Persons”). COMPANY UNDERSTANDS THAT ALTHOUGH THE DESIGNATED
PERSON IS ADMITTED TO PRACTICE LAW IN THE STATE OF CALIFORNIA,
CONSULTANT IS NOT A LEGAL SERVICES CORPORATION AND THE SERVICES OFFERED
BY CONSULTANT WILL CONSIST OF BUSINESS AND STRATEGIC CONSULTING SERVICES, AND
NEITHER THE CONSULTANT NOR THE DESIGNATED PERSON WILL ACT AS LEGAL
COUNSEL FOR THE COMPANY AS PART OF THE SERVICES. WHILE COMPANY MAY
ASK CONSULTANT OR THE DESIGNATED PERSON FROM TIME TO TIME TO ASSIST
IN STRUCTURING TRANSACTIONS, REVIEWING AND/OR ADVISING ON AGREEMENTS AND OTHER
DOCUMENTS AND ASSISTING IN THEIR NEGOTIATION (WHICH MAY INVOLVE ISSUES OF
A MIXED BUSINESS/LEGAL NATURE INVOLVING THE COMPANY’S RIGHTS AND
OBLIGATIONS IN CERTAIN SITUATIONS AND CIRCUMSTANCES), COMPANY UNDERSTANDS THAT IT
SHOULD OBTAIN LEGAL ADVICE FROM LEGAL COUNSEL SEPARATE FROM CONSULTANT OR
THE DESIGNATED PERSON, AND WILL LOOK TO SUCH COUNSEL FOR LEGAL ADVICE
AS TO SUCH MATTERS. THE COMPANY ALSO UNDERSTANDS THAT SINCE NEITHER
CONSULTANT NOR THE DESIGNATED PERSON WILL BE REPRESENTING COMPANY AS A
LAWYER, COMMUNICATIONS BETWEEN US WILL NOT BE COVERED BY THE
ATTORNEY-CLIENT PRIVILEGE.  
  
 2. Term and Termination. Except as set forth in any Project Schedule attached to this Agreement, this shall continue until terminated by either party upon ten (10) days’ written notice, provided that
termination by Consultant shall not be effective until completion of any specifically defined term set forth on any Project Schedule applicable at the time of such notice, unless otherwise agreed. Notwithstanding the foregoing, this Agreement may be
terminated, at the sole option of the Company, upon the death, disability, termination of employment by Consultant or inability or unavailability to render the Services for any reason of one or more of the Designated Persons. If the Company elects
so to terminate this Agreement, Company shall deliver written notice to the Consultant of such termination, which termination will become effective immediately, and shall pay to Consultant, within 30 days of such termination the compensation due
hereunder for services rendered through the date of termination. The “disability” of a Designated Person shall be deemed to occur if such Designated Person becomes physically or mentally disable, whether totally or partially, so that such
Designated Person is substantially unable to perform the Services for such period as the Company may reasonably determine in light of any deadlines or delivery dates set forth in the applicable Project Schedule. 
  
 3. Payment for Services; Expenses; Equipment. 
  
 3.1 Charges. As full compensation for the Services to be provided by
Consultant pursuant to any Project Schedule for activities that are substantiated, pre-approved and actually worked, Company agrees to pay Consultant in such amounts, at such times and in such manner as is set forth in such Project Schedule.
Consultant has the right to perform services for others and the sole right to control and direct the means, manner and method by which the services required by this Agreement will be performed, consistent with the terms of this agreement.

  
 3.2 Equipment. Consultant shall furnish, at
Consultant’s sole expense, all equipment and materials used to perform the Services, including but not limited to, telephone lines, office space and support services, and personal computers and modems. 
  
 4. Independent Consultant. It is understood and agreed that Consultant
shall perform the Services as an independent Consultant and consultant. No Designated Person shall be deemed to be an employee of Company. No Designated Person shall be entitled to any benefits provided by Company to its employees, and Company will
make no deductions from any of the payments due to Consultant hereunder to pay any governmental agency or authority, except as may otherwise be required by law. Consultant agrees that Consultant shall be responsible for any and all taxes and other
payments due on payments received by Consultant from Company hereunder and for all compensation, withholding, and all other employment-related benefits due to any Designated Person. 

 5. Representations and Warranties of Consultant. 
  
 5.1 Original Development. Each of Consultant and all Designated
Persons who signs a Project Schedule represents and warrants that (i) during Company’s retention of Consultant, neither Consultant nor any such Designated Person will disclose to Company, or use, or induce Company to use, any confidential,
proprietary or trade secret information of others; (ii) he, she or it has returned all property and confidential, proprietary and trade secret information belonging to all prior employers or Companys, if any, and that no such information has been or
will be used in connection with rendering any of the Services hereunder; and (iii) performance of the terms of this Agreement will not breach any agreement to keep such information in confidence or in trust. Neither Consultant nor any Designated
Person has entered into, and each of them further agrees not to enter into, any oral or written agreement in conflict herewith. 
  
 5.2 Other Agreements. Consultant and each Designated Person represents and warrants that Consultant’s signing of this Agreement and the
performance of Consultant’s and any Designated Person’s Services hereunder is not and will not be in violation of any other contract, agreement or understanding to which Consultant or any Designated Person is a party or by which any of
them is bound. 
  
 5.3 Current Information.
Consultant has truthfully completed the information required upon Attachment 1, attached hereto and incorporated herein by reference, and that Independent Consultant will apprise Company, in writing, of any changes thereto through the end of
the fiscal tax year in which this Agreement expires or is terminated, regardless of whether this Agreement is then still in full force and effect. 
  
 5.4 Legal Status. Consultant represents and warrants that the Consultant is legally allowed to work in the United States and its territories
and is in compliance with all federal, state, county, and local regulations, and will maintain this status until the completion or termination of this Agreement. Consultant further represents and warrants that any person or organization with whom
the Consultant participates in the performance of any aspect of this Agreement is or will be legally allowed to work in the United States and its territories during the entire term of that participation. 
  
 5.5 Compliance with Worker’s Compensation and Unemployment
Compensation Insurance Requirements. Consultant shall provide and keep in force worker’s compensation and unemployment compensation insurance in the amounts required by law, and shall be solely responsible for the acts of any individual to
whom it supplies to Company, and their subConsultants, agents, and employees. 
  
 6. Confidential Information. 
  
 6.1 Confidentiality. In connection with this Agreement, the Company may disclose to Consultant or any Designated Person certain information (i) that is marked or otherwise identified, orally or in writing, as confidential or
proprietary information of the Company (“Confidential Information”) prior to, upon or promptly after receipt by Consultant or any Designated Person; or (ii) which Consultant or any Designated Person should recognize from the circumstances
surrounding the disclosure to be Confidential Information. Consultant and each Designated Person (x) shall hold all Confidential Information in confidence and will use such information only for the purposes of fulfilling Consultant’s
obligations hereunder and for no other purpose, and (y) shall not disclose, provide, disseminate or otherwise make available any Confidential Information of the Company to any third party, in either case without the express written permission of the
Company. 
  
 6.2 Scope. The foregoing obligations in
Section 6.1 shall not apply to (a) use or disclosure of any information pursuant to the exercise of Consultant’s rights under this Agreement; (b) information that is or becomes generally known or available by publication, commercial use or
otherwise through no fault of Consultant or any Designated Person; (c) information that is known by Consultant or any Designated Person prior to the time of disclosure and is not subject to restriction; (d) information that is independently
developed or learned by Consultant or any Designated Person other than pursuant to this Agreement; (e) information that is lawfully obtained from a third party who has the right to make such disclosure without restriction; (f) any disclosure
required by applicable law, provided that Consultant or any Designated Person, as the case may be, shall use reasonable efforts to give advance notice to and cooperate with the Company in connection with any efforts to prevent such disclosure; or
(g) information that is released for publication by the Company in writing. 
  
 6.3 Third Party Information. Consultant and each Designated Person recognizes that the Company has received and in the future will receive from third parties their confidential or proprietary information
subject to a duty on the Company’s part to maintain the confidentiality of such information and to use it only for certain limited purposes. Consultant and each Designated Person agrees that each owes the Company and such third 

 parties, during the term of this Agreement and thereafter, a duty to hold all such confidential and proprietary
information in the strictest confidence and not to disclose it to any person, firm, or corporation (except as necessary in carrying out their respective work for the Company in a manner consistent with the Company’s agreement with such third
party) or to use it for the benefit of anyone other than for the Company or such third party (consistent with the Company’s agreement with such third party) without the express written authorization of the Company. 
  
 7. Other Covenants and Agreements. 
  
 7.1 Freedom to Render Services to Others. Company understands that
Consultant is and will continue to be engaged in other professional, technical, investment and financial activities during the term of this Agreement. Consultant is now and will remain free to engage in any activity of Consultant’s choice; to
lawfully invest in public or private entities, to involve himself personally in business and strategic planning, venture capital activities; to serve as a member on technical and scientific advisory boards; to act as a consultant or provide
consulting services to individuals, business entities or governmental or academic institutions, without limitation. 
  
 7.2 Company Clients and Associates. Consultant agrees not to solicit or do business with those Clients or associates of Company of which Consultant
gained knowledge through Consultant’s relationship with Company, if such business could present any possible conflict of interest with the Work between Consultant and Company. 
  
 8. Ownership. Unless otherwise specified in a Project Schedule, all work performed under any Project Schedule, and
all materials developed or prepared for the Company by Consultant or any Designated Person under such Project Schedule (whether or not such Project Schedule is completed) (such materials, “Creations”), are Confidential Information and the
property of the Company, and all right, title and interest therein shall vest in the Company and shall be deemed to be a work made for hire and made in the course of the Services rendered hereunder. To the extent that title to any such works may
not, by operation of law, vest in the Company or such Creations may not be considered works made for hire, all right, title and interest therein are hereby irrevocably assigned to the Company by Consultant and each Designated Person. All such
Creations shall belong exclusively to the Company, with the Company having the right to obtain and to hold in its own name all copyrights, registrations or such other protection as may be appropriate to the subject matter, and any extensions and
renewals thereof. Consultant and each Designated Person agrees to give the Company and any person designated by the Company any reasonable assistance, at the cost and expense of the Company, to perfect the rights defined in this Section 7.
Consultant and each Designated Person further waives any “moral” rights, or other rights with respect to attribution of authorship or integrity of such Creations as Consultant or any Designated Person may have under any applicable law.

  
 9. Indemnification. 
  
 9.1. Except as otherwise provided below, Company will (i) indemnify
Consultant and hold Consultant harmless from and against any losses, claims, damages, or liabilities, including without limitation judgments, fines and amounts paid in settlement (collectively “losses”) resulting from any claim, action or
proceeding against Consultant which arises out of or in connection with this Agreement and Consultant’s services rendered pursuant hereto (each, a “claim”), and (ii) pay, or reimburse Consultant for, all costs and expenses (including
without limitation counsel fees, court costs, witness fees and the costs and expenses of investigation) actually and reasonably incurred by Consultant in connection with preparing for or defending any pending or threatened claim (collectively,
“costs”). 
  
 9.2. The obligations of Company
pursuant to the immediately preceding paragraph will not apply to any claim which results from the bad faith, gross negligence or willful misconduct of Consultant, and as to any such claim, Consultant will be solely responsible for, and will
indemnify Company and hold it harmless from and against, any associated losses or costs; provided, however, that Consultant’s liability to Company under this paragraph will be limited as set forth in paragraph 12(e) below.

  
 9.3. Consultant will exercise reasonable diligence in
promptly notifying Company of any claim for which indemnification may be sought by Consultant and Company may, at its written election, assume the defense of any such claim, including the selection and appointment of counsel and the defense or
settlement thereof. If Company elects to assume defense of a claim, counsel chosen by Company will be subject to Consultant’s approval, which will not be unreasonably withheld. Further, Company will not settle any action or claim in any manner
which would include or constitute an admission by Consultant of liability, guilt in connection with the commission of any crime or the violation of any statute, law, regulation or ordinance, or otherwise impose any penalty or limitation on
Consultant without Consultant’s written consent, which may be given or withheld in Consultant’s sole discretion. 

 9.4. The agreements and obligations of Company contained in this Section 3 will continue during
the term of this Agreement and thereafter so long as Consultant remains subject to any possible claim or threatened, pending or completed action, suit or proceeding arising out of or in connection with this Agreement and Consultant’s services
rendered pursuant to this Agreement 
  
 10. Equitable Relief.
Consultant and each Designated Person recognizes that nothing in this Agreement is intended to limit any remedy of Company under the California Uniform Trade Secrets Act. In addition, Consultant and each Designated Person recognizes that the
covenants contained in Sections 6 and 8 hereof are reasonable and necessary to protect the legitimate interests of the Company, that the Company would not have entered into this Agreement in the absence of such covenants, and that the violation or
threatened violation of such covenants will cause Company irreparable harm and significant injury, the amount of which may be extremely difficult to estimate, thus, making any remedy at law or in damages inadequate. Therefore, Consultant and each
Designated Person agrees that Company shall have the right to apply to any court of competent jurisdiction for an order restraining any breach or threatened breach of this Agreement and for any other relief Company deems appropriate, without the
necessity of posting of any bond or security. This right shall be in addition to any other remedy available to Company in law or equity. 
  
 11. Return of Company Property. On termination of this Agreement, or at any time the Company so requests, Consultant will deliver immediately to
the Company all property belonging to the Company and all material containing or constituting Confidential Information, including any copies in my possession or control, whether prepared by Consultant or by others, including without limitation any
Designated Persons. 
  
 12. Miscellaneous. This contract
will be governed by and construed in accordance with the laws of the State of California, without giving effect to its conflicts of laws rules. Whenever the content of this Agreement requires, the masculine gender shall be deemed to include the
feminine. If any provision of this Agreement is determined to be invalid, illegal or unenforceable, the validity or enforceability of the other provisions shall not be affected. Consultant shall not assign, sell, transfer, delegate or otherwise
dispose of, whether voluntarily or involuntarily, or by operation of law, any rights or obligations under this Agreement. Any purported assignment, transfer, or delegation by Consultant shall be null and void. No term or provision of this Agreement
may be amended, waived, released, discharged or modified in any respect except in writing, signed by the parties hereto. In circumstances where the Services change and/or new Service arrangements are made, the terms and conditions as described by
all other provisions of this Agreement will remain in full force and effect whether or not a new Agreement, addendum, or change order is executed by both parties. This Agreement sets forth the entire understanding between the parties with respect to
the subject matter hereof, and there are no terms, conditions, representations, warranties or covenants other than those contained herein. This Agreement supersedes any previous agreements or understandings between the parties with respect to the
subject matter hereof, whether written or oral. Failure to enforce any provision of this Agreement shall not constitute a waiver of any term hereof. The Headings and Captions in this Agreement are included for purposes of clarity and do not
represent material terms or conditions of thus agreement. 
  
 13. Arbitration. Any and all disputes under this Agreement or otherwise relating to Consultant’s engagement by Company, except disputes relating to Sections 6 and 8 of this Agreement, shall be submitted to binding, expedited
arbitration to take place in Los Angeles, California before a single arbitrator (who shall be an attorney experienced in matters relating to corporate and labor matters) in accordance with the Commercial Rules of the American Arbitration
Association. The parties shall be entitled to conduct a reasonable amount of discovery in connection with such arbitration. The arbitrator shall have the right to award damages or other forms of legal and/or equitable relief, to the extent permitted
and not waived hereunder. The award or decision rendered by the arbitrator shall be final, binding and conclusive and judgment on such award or decision may be entered by any court of competent jurisdiction. The arbitrator shall award costs and
attorneys’ fees to the prevailing party.Amendment No. 1 to Agreement to Provide Additional Capital

 Exhibit 10.10 
  
 AMENDMENT NO. 1 TO 
 AGREEMENT TO PROVIDE ADDITIONAL CAPITAL 
 Dated as of August 11, 2004 
  
 This AMENDMENT NO. 1 TO AGREEMENT TO PROVIDE ADDITIONAL CAPITAL (this “Amendment”), amends the Agreement To Provide Additional
Capital is made dated as of June 4, 2004, (the “Agreement”) by and between Arrowhead Research Corporation, a Delaware corporation (“Arrowhead”), and Insert Therapeutics, Inc., a California corporation
(the “Company”). Capitalized terms not otherwise defined in this Amendment have the meanings ascribed to such terms in the Agreement. In consideration of the mutual covenants and agreements contained herein, the parties
hereby agree amend and modify the Agreement as set forth below: 
  
 1. Failure of Arrowhead to Make a Required Contribution. To clarify the original intent of the parties with respect to Arrowhead Research’s payment obligations, Paragraph 2 of the Agreement shall be amended and restated
in its entirety to read as follows: Twenty Percent (20%) of its 24,496,553 
  
 “In the event that Arrowhead fails to provide, on a timely basis, any amount of additional funding that Arrowhead is obligated to provide pursuant to the provisions of paragraph 1 above, then in addition to any
consequences of such failure provided in the Restated Certificate of Incorporation or By-Laws of the Company, as of such Milestone Date, Arrowhead shall forfeit to the Company that number of shares of Series B Preferred Stock (or any shares of
Common Stock into which such shares of Series B Preferred Stock may have been converted (collectively, with the Series B Preferred Stock, the “Securities”) equal to (X) 24,496,553 multiplied by (Y) the quotient obtained by
dividing (i) the sum of (A) the amount of additional capital which Arrowhead failed to provide with respect to the Milestone Date in question, plus (B) the total amount of capital which would be due on satisfaction of Milestones on any future
Milestone Dates, by (ii) by Five Million (5,000,000). Forfeited shares shall be rounded up to the nearest whole number.” 
  
 For example, if Arrowhead fails to provide $1,500,000 of additional capital upon the Company achieving Milestone 2, Arrowhead would forfeit 14,697,931
Securities (24,496,553 X ($3,000,000/$5,000,000). To the extent there is any upward or downward adjustment in the number of Securities based upon their terms or corporate action, including, but not limited to, a distribution, dividend, stock split
or reverse stock split, but specifically excluding any adjustment that may result from forfeiture under this Paragraph 2, then the calculation of the number of Securities to be forfeited shall be based on the adjusted number of Securities held by
Arrowhead.” 
  
 2. No Other Amendments. Except
as specifically amended by this Amendment, all provisions of the Agreement shall remain in full force and effect. 
  
 3. Counterparts and Facsimile. This Amendment may be executed in two or more counterparts and by facsimile, each of which will be deemed an
original, but all of which together will constitute one and the same instrument. 
  
 IN WITNESS WHEREOF, the parties have caused this Amendment to be duly executed as of the date first above written. 
  

							
	 “Arrowhead”
	 	 “Insert Therapeutics”

	 Arrowhead Research Corporation
	 	 Insert Therapeutics, Inc.

				
	 By:
	 	 /s/ R. BRUCE STEWART

	 	 By:
	 	 /s/ JOHN PETROVICH

	 Name:
	 	 R. Bruce Stewart
	 	 Name:
	 	 John Petrovich

	 Title:
	 	 President
	 	 Title:
	 	 President

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