Document:

Development and License Agreement

 Exhibit 10.8 
 ***Text Omitted and Filed Separately 
 with the Securities and Exchange
Commission. 
 Confidential Treatment Requested 
 Under 17 C.F.R. Sections 200.80(b)(4) 
 and 230.406. 

EXECUTION COPY 

DATED 20 AUGUST 2004 
 JAGOTEC AG 
 and 

SKYEPHARMA AG 
 and 
 NITEC PHARMA AG 

 
  
 DEVELOPMENT & LICENCE AGREEMENT 
  

 

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 THIS DEVELOPMENT and LICENCE AGREEMENT (this “Agreement”) is made on 20 August 2004 by and between: 
  

	(1)	JAGOTEC AG, a Swiss corporation having its place of business at Eptingerstrasse 5 1, CH-4 132 Muttenz, Switzerland (hereinafter referred to as
“Jagotec”); 

  

	(2)	SKYEPHARMA AG, a Swiss corporation having its place of business at Eptingersttasse 5 1, CH-4 132 Muttenz, Switzerland (hereinafter referred to as
“SkyePharma”; and SkyePharma and Jagotec hereinafter sometimes collectively referred to as “Skye”), and 

  

	(3)	NITEC PHARMA AG, a Swiss corporation, having a place of business at Röschenzerstrasse 9, CH-4153 Reinach, Switzerland (hereinafter referred to as
“Nitec”). 

 WITNESSES AS FOLLOWS: 
  

	A.	 By an agreement effective as of 18th day of August 1998, Skye and Merck KGaA, a German corporation, having a place of business Frankfurterstrasse 250,
D-64271 Darmstadt, Germany (hereinafter referred to as “Merck) entered into an agreement relating to the development of the product, Prednisone using certain proprietary technology and know-how owned by Jagotec relating to pharmaceutical
systems for the controlled and/or modified release of active substances, including but not limited to, Jagotec’s patented GEOMATRIX® Technology (as defined below) (hereinafter called the “Merck Agreement”). 

 

	B.	By an agreement between Merck and Nitec signed by Merck on 14 July 2004 and by Nitec on 2 August 2004 (the “Technology Transfer Agreement”), Merck
assigned the Merck Agreement to Nitec, effective as of the Effective Date of this Agreement. 

  

	C.	Skye has consented to the assignment of the Merck Agreement pursuant to the Technology Transfer Agreement, provided that certain modifications agreed between the
Parties (as defined below) are made to the contractual arrangements under the Merck Agreement. 

  

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	D.	On signature of this Agreement, the provisions of the Merck Agreement shall be terminated and replaced in their entirety with the terms and conditions set out below.

 NOW, THEREFORE, in consideration of the premises, mutual covenants and agreements contained in this Agreement and intending to
be legally bound by it, the Parties hereby agree as follows: 
  

	1	Definitions 

 For purposes of this
Agreement, the terms defined in this Section 1 shall have the following meanings: 
  

	1.1	“Active Drug” shall mean each of the substances Prednisone, Prednisolone and Methylprednisolone of a quality suitable for the manufacture of Product
meeting the Specifications; 

  

	1.2	“Affiliate” shall mean, any corporation, partnership or other entity controlled by, controlling or under common control with, either Party, with
“control” meaning (i) with respect to either Party direct or indirect beneficial ownership of more than 50% of the voting power of, or more than 50% of ownership interest in, such corporation, partnership or other entity and for the
avoidance of doubt, Jagotec and SkyePharma shall be regarded as Affiliates; 

  

	1.3	“Background IP” shall mean any intellectual property owned by the respective Parties on the Effective Date of this Agreement in respect of the Nitec
Know-How or the Skye Know-How which is or may be used under this Agreement and in the case of Nitec shall include all relevant rights intellectual property owned or used by Merck under the Merck Agreement necessary or desirable for use under this
Agreement; 

  

	1.4	 “Commercially Reasonable Efforts” means those efforts and resources that would be used by an established pharmaceutical company were
it developing, manufacturing, promoting and detailing its own pharmaceutical products which are of similar market potential as the Product, taking into account product labelling, market potential, past performance, economic return, the regulatory

  

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environment and competitive market conditions in the therapeutic area, all as measured by the facts and circumstances at the time such efforts are due. 

 

	1.5	“Confidential Information” shall mean any and all of the Skye Know-How and the Nitec Know-How, as well as any and all information developed during the
course of this Agreement, including, but not limited to, materials and techniques, analytical and testing methods, chemical formulae and specifications, product design criteria and test data, and technical information relating to product production
and commercial plans; 

  

	1.6	“Development Costs” shall mean all reasonable out-of-pocket costs (except those resulting from any breach by Skye hereunder) of the Development
Programme performed by Jagotec hereunder; 

  

	1.7	“Development Programme” shall mean the programme of work to be carried out by the Parties attached hereto as Exhibit C as may be amended by the Parties
in writing acting in good faith within thirty (30) days of the signature of this Agreement and thereafter as may be amended in writing by the Parties from time to time and “Development” shall be construed accordingly;

  

	1.8	“Dose Strength” shall mean with respect to Product each of the formulations containing 1, 2, 5 and 10 mg of Active Drug, respectively;

  

	1.9	“Effective Date” shall mean the date of signature of this Agreement; 

 

	1.10	“FDA” shall mean the U.S. Federal Food and Drug Administration and any successor agency thereof; 

 

	1.11	“First Launch” shall mean the first commercial sale of the Product in any country of the Territory to any unaffiliated third party in commercial
quantities following receipt of all applicable pricing and reimbursement approvals; 

  

	1.12	“Foreground IP” shall mean any intellectual property that arises or is developed by either party arising out of this Agreement;

  

	1.13	
“GEOMATRIX® Technology”
shall mean all of Skye’s oral controlled and/or modified drug release delivery and related technologies together with all improvements thereon and thereto; 

 

	1.14	 “Intellectual Property” shall mean any patent, including patent applications, divisional, continuation or continuation-in-part
applications, re-issues, registered 

  

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design copyright, database right, design right, topography right, trademark, service mark application to register any of such rights, trade secret, right in unpatented know-how and any other
intellectual or industrial property right of any nature whatsoever in any part of the world; 

  

	1.15	“Jagotec Manufacturing Agreement” shall mean the Manufacturing and Supply Agreement to be negotiated in good faith at the appropriate time by and
between Jagotec or any of its Affiliates and Nitec or any of its Affiliates on the manufacturing and supply of Product; 

  

	1.16	“Licence” shall mean the licence granted to Nitec as set out in Section 5.1; 

 

	1.17	“Mutual Recognition Procedure” shall mean the decentralized procedure to obtain a marketing authorisation for prescription drugs in EU countries;

  

	1.18	“Net Sales” shall mean, with respect to any Product, the invoiced sales price of such Product in finished package form invoiced by Nitec and/or its
Affiliates and/or its sub-licensee(s) to any independent customer other than Nitec Affiliates or sub-licensee(s), less only (a) sales, use, value added and other direct taxes (but excluding any income tax) actually incurred and paid by Nitec
and/or its Affiliates and/or its sub-licensee(s); and (b) customs duties, surcharges and other governmental charges incurred by Nitec and/or its Affiliates and/or its sublicensee(s) in connection with the exportation or importation of such
Product in final form, and (c) a lump sum deduction of [...***...] for all trade discounts, rebates, commissions, retroactive price reductions, amounts repaid or credited by reason of rejections, returns, and the like;

  

	1.19	“Nitec Know-How” shall mean all of Nitec’s and/or its Affiliates’ information and data (including, without limitation, information and data
of Merck under the Merck Agreement), which are not generally known including, but not limited to, patent claims and related information not yet disclosed to the public, formulae, procedures, protocols, techniques and results of experimentation and
testing which relate to Active Drug, and/or are useful and/or necessary to develop, make, use or sell any product containing Active Drug; 

  

	1.20	“Nitec Manufacturing Licence” shall mean the licence to Nitec granted pursuant to the option set out in Section 5.2; 

 

	1.21	“Party” or “Parties” shall mean SkyePharma, Jagotec and Nitec or any of them; 

 

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	1.22	 “Patents” shall mean all patents and patent applications heretofore or hereafter filed or having legal force in any country owned by
or licensed to Skye and/or its Affiliates relating to the Product, which claim the GEOMATRIX® Technology or the
process of manufacture by use of, or the use of, the GEOMATRIX® Technology and are set out in the attached
Exhibit A. Exhibit A is hereby deemed to be amended to include any and all patent applications relating to the subject matter of this Agreement eventually to be filed by or owned by or licensed to Skye or its Affiliates after the Effective Date,
together with any and all corresponding foreign patents and patent applications which issue therefrom, and all divisionals, continuations, continuations-in-part, reissues, renewals, extensions, substitutions, confirmations or additions to any such
patents or patent applications; 

  

	1.23	“Phase III Clinical Study” shall mean a large scale clinical trial in patients suffering from rheumatoid arthritis, the primary goal of which is to
establish Product efficacy (and chronic safety) according to Regulatory Authority registration rules or regulations; 

  

	1.24	 “Product” shall mean the pharmaceutical orally-administered controlled-release formulation (intended to exhibit a lag phase of at
least one hour, with substantially all of the drug release immediately thereafter) containing Prednisone, Prednisolone and/or Methylprednisolone, presented as a compressed tablet developed pursuant to this Agreement and using the GEOMATRIX® Technology, and shall include all Dose Strengths unless otherwise explicitly stated; 

 

	1.25	“Registration” shall mean the granting of any and all approvals and registrations of Product by any Regulatory Authority, including without limitation
price approval, which are required and/or necessary under any applicable law, rule, regulation or other governmental order to manufacture, market, distribute and sell Product in any country of the Territory; 

 

	1.26	“Regulatory Authority” shall mean the FDA and any equivalent competent regulatory authority in the other countries of the Territory;

  

	1.27	 “Skye Know-How” shall mean all of Skye’s and/or its Affiliates’ information and data, which are not generally known
including, but not limited to, patent 

  

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claims and related information not yet disclosed to the public, formulae, procedures, protocols, techniques and results of experimentation and testing, which relate to the GEOMATRIX® Technology and/or are useful and/or necessary to develop, make, use or sell Products using the GEOMATRIX® Technology; 

  

	1.28	“Specifications” shall mean the preliminary specifications of the Product set forth in Exhibit B attached hereto to be updated from time to time by
mutual agreement of the Parties; 

  

	1.29	“Technical Agreement” shall mean the additional contract to be entered into by Nitec as contract giver and Jagotec as contract acceptor, allocating the
respective pharmaceutical responsibilities relating to the manufacture and control of Products; 

  

	1.30	“Territory” shall mean all countries and territories in the world. 

 

	2	Development Preamble and further Development Programme 

  

	2.1	Jagotec has, prior to the execution of this Agreement, developed the Product under the Development and Licence Agreement with Merck, which shows some promising results.
In particular, the Parties have agreed to use the results as the basis of further development under this Agreement, the terms of which are hereby incorporated into this Agreement as set out below. 

 

	2.2	 Jagotec and Nitec undertake to conduct the further development of the Product in rheumatoid arthritis (and such other indications (e.g. asthma, IBD) as
may be agreed between the Parties in writing from time to time) in accordance with the Development Programme in an efficient and professional manner, and shall apply generally accepted Good Laboratory, Good Clinical and Good Manufacturing Practices
(each as applicable to pharmaceutical products for human use in the European Union and similar regulations applicable in other territories),. The Development shall also comply with the current guidelines of the European Union (e.g. Note for guidance
on quality of modified release products). Nitec shall actively support Jagotec regarding the development and studies to be executed by Jagotec under this Agreement as may be reasonably required by Jagotec from time to time. In particular, Nitec
shall provide information 

  

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reasonably requested by Jagotec relating to the Active Drug for the purposes of carrying out this development, including, but not limited to physico-chemical characteristics, safe-handling
instructions, in-vitro analytical methods, degradation products and standards and analytical methods therefore, all to the extent that any such information has not been delivered to Jagotec under the development and Licence Agreement with Merck. Any
costs and expenses incurred by Nitec in connection with such support shall be borne by Nitec. 

  

	2.3	Jagotec shall use all Active Drug supplied to it by Nitec hereunder solely and exclusively in connection with the Development. 

 

	2.4	Due to the nature and complexity of the development and the respective studies as set forth in this Agreement, the Parties recognize and acknowledge that problems and
delays might render the timeframe of the development difficult or impossible to accomplish. The Parties agree that they shall immediately inform each other in writing in the event that significant problems or delays are encountered or envisaged
during the course of the development and shall discuss such problems and delays in order to mutually agree on Commercially Reasonable Efforts to resolve such problems or delays. Nothing under this Section 2.4 shall affect the timelines set out
in Section 3 except to the extent of delays resulting directly from the breach of its obligations under this Agreement by Jagotec. 

  

	2.5	Nitec acknowledges and agrees that Jagotec’s obligations under this Agreement shall be strictly limited to the development steps and tasks explicitly listed and
described in the Development Programme, and that any amendment, change and alteration to, or extension of, any such development steps and tasks shall require the mutual agreement by the Parties. 

 

	2.6	Nitec shall bear all Development Costs. Nitec and Jagotec shall have the right to approve any additional activities not listed in Exhibit C which are proposed by
Jagotec or Nitec. 

  

	2.7	Nitec shall reimburse Jagotec on a quarterly basis any and all Development Cost incurred by Jagotec hereunder upon receipt of the respective invoices pursuant to
Section 2.9 below. 

  

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	2.8	During the term of this Agreement, Jagotec shall provide Nitec on a quarterly basis with an overview of the work intended by Jagotec to be performed according to the
Development Programme during the following three (3) months (hereinafter the “Quarterly Workplan”). Each such Quarterly Workplan shall contain information regarding the steps to be performed by Jagotec hereunder together with an
estimate of the man-hours expected to be spent on such steps and the anticipated Development Costs. Upon receipt of any such Quarterly Workplan, Nitec may comment thereon or disapprove certain steps included therein by written notice within five
(5) business day after receipt of each such Quarterly Workplan, provided that each Quarterly Workplan shall be deemed approved by Nitec if no such written notice is received by Jagotec within such five (5) business days, and provided
further that Jagotec shall have no responsibility for any delay in the Development Programme caused by or resulting from any such notice from Nitec. 

  

	2.9	Jagotec shall issue quarterly a report (“Quarterly Report”) reasonably detailing all development steps performed during the preceding three (3) month
period, and Jagotec shall, simultaneously with each such Quarterly Report, issue an invoice covering all cost and expenses incurred by Jagotec hereunder in accordance with the terms of this Agreement including any Development Costs over the period
covered by such Quarterly Report applying a rate of [...***...] per man-hour spent. Any excess of the aggregate amount of development fees paid by Nitec over the aggregate amount(s) invoiced by Jagotec shall be credited by Jagotec
against future invoices hereunder. 

  

	2.10	Nitec undertakes to settle each invoice so issued, which shows a balance in favour of Jagotec, within [...***...] as of the respective invoice date.

  

	3	Responsibilities 

  

	3.1	Nitec will use all Commercially Reasonable Efforts to perform at its sole cost and expense, the following: 

 

	(a)	all clinical studies, including without limitation: 

  

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	 	(i)	 commence the Phase III Clinical Study in Rheumatoid Arthritis as agreed with the German authority February, 17th 2004 within [...***...] of the Effective Date;

  

	 	(ii)	complete the above mentioned (3.1(a)(i) Phase III Clinical Study within [...***...] of commencing the Phase III Clinical Study, and;

  

	 	(iii)	other development steps and tasks (other than those which are assigned to Jagotec as may be agreed between the parties from time to time) which are required and/or
necessary and/or deemed reasonable to be performed pursuant to all applicable law, statute or regulation, in order to apply for, and subsequently receive, Registrations for Product in at least one major European market and eventually other countries
of the Territory; 

  

	(b)	apply for and diligently pursue, in Nitec’s (or its Affiliates’) own name; Registrations for Product in Rheumatoid Arthritis with the Regulatory Authorities
in at least one major European market within [...***...] of the completion of the Phase III clinical studies, and eventually other countries of the Territory; 

 

	(c)	apply for and diligently pursue (except where the primary obligation for doing so is placed on Jagotec under relevant legislation) any and all approvals required by any
applicable law, statute or regulation to manufacture Product at the manufacturing site as set forth in the Jagotec Manufacturing Agreement or any other facility to subsequently manufacture Product; 

 

	(d)	within [...***...] of the receipt of first Registration for Product in the reference member state, being such country referred to in Section 3.1(b), to start
and thereafter diligently pursue the Mutual Recognition Procedure or other procedure to obtain Registration in at least three other countries of the Territory; and 

 

	(e)	launch or have launched the Product in at least three European Union countries within [...***...] following receipt of Registration in those countries of the
European Union. 

  

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	3.2	Nitec may decide at its own discretion and according to its business strategy, in which country of the Territory to first apply for Registration of Product and initiate
and pursue the steps required to be performed for successful Registration of Product. 

  

	3.3	In the event that Nitec does not in any material respect meet any of its obligations pursuant to Section 3.1 above, Skye may thereafter call a meeting with Nitec
at which Skye will determine, at Jago’s sole option, either to (i) allow Nitec a further [...***...] to complete such obligation, or (ii) Skye to terminate the Agreement in which case the terms of Section 10.4
(c) shall apply. 

  

	3.4	Jagotec agrees to provide such technical assistance and consultation in addition to the tasks assigned to Jagotec pursuant to this Agreement as may be reasonably
required by Nitec in connection with the development, testing, performance of clinical studies, applications for Registrations or similar services, provided that Nitec shall pay to Jagotec an amount of [...***...] spent by Jagotec personnel in
providing such additional assistance and consultation. In addition to such fee, Nitec undertakes to reimburse Jagotec for all cost and expenses incurred in connection with travel and accommodation of Jagotec personnel providing upon specific request
by Nitec any such assistance and consultation at locations remote from their usual working location to the extent separately agreed upon. 

  

	3.5	Jagotec shall have no responsibility whatsoever in respect of the availability or quality of the results of the development steps to be performed by Nitec pursuant to
Section 3.1 above, unless otherwise agreed upon by the Parties in writing with respect to any specified development step or part thereof to be performed by Jagotec in accordance with Section 3.4 above. 

 

	3.6	 Nitec undertakes to provide to Jagotec upon availability with all information on any of the development steps performed by Nitec under Section 2.1
above in reasonable detail or as reasonably required by Jagotec to perform its obligation under this Agreement. In particular, but without limitation, Nitec shall provide Jagotec upon availability with results, data, reports and similar information
obtained by any of the studies, testing, Registration procedures or the like performed by Nitec under this Agreement. Any and all such information provided by Nitec to Jagotec shall be treated by Jagotec as Confidential Information and

  

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remain subject to the confidentiality and non-use obligations contained in Section 8 below. 

  

	3.7	In the event that the Parties shall deem the results of any of the development steps to be performed by Nitec under this Section 3, including without limitation,
the results of any clinical study (including Phase III Clinical Study) performed hereunder, to be unsatisfactory for any reason, the Parties may mutually agree to abandon the development of the Product under this Agreement and terminate this
Agreement with immediate effect. 

  

	3.8	The allocation of all technical and pharmaceutical responsibilities shall be included in the Technical Agreement which the Parties shall negotiate in good faith within
thirty (30) days of the Effective Date. 

  

	4	Proprietary Rights and Patents 

  

	4.1	Rights to Foreground IP 

  

	(a)	 Any Foreground IP relating specifically and exclusively to the GEOMATRIX® Technology or the process of manufacture by use of, or the use of the GEOMATRIX® Technology, including the formulation of any compound (including Active Drug) with GEOMATRIX® Technology shall vest in and be owned absolutely by Jagotec, irrespective which party has created or developed such Foreground IP or its contribution to it
(hereinafter referred to as “Skye IPR”). 

  

	(b)	Any Foreground IP relating specifically and exclusively to the Product containing Active Drug, any use of the Active Drug, or any attribute or property of the Active
Drug, shall vest in and be owned absolutely by Nitec, irrespective which party has created or developed such Foreground IP or its contribution to it (hereinafter referred to as “Nitec IPR”). 

 

	(c)	All Foreground IP other than that set out in Section 4.1(a) and (b) will be owned (i) by the Party developing or discovering it; or (ii) if jointly
developed or discovered, shall be owned jointly (together, “Other IP”) all as determined in accordance with the legislation applying in the country or jurisdiction where such development or discovery shall take place.

  

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	4.2	Rights to Background IP 

  

	(a)	All Background IP is and shall remain the exclusive property of the party owning it (or if applicable from the third party from whom its rights to use the Background IP
has derived). 

  

	(b)	In case the Foreground IP of either party is dependent on any or all Background IP of the other party, the parties agree to the following: 

 

	 	(i)	in case Skye IPR or Other IP is dependent on any or all Background IP of Nitec (hereinafter referred to as “Dependent Skye IPR”), Nitec shall grant to Jagotec
a non-exclusive, perpetual, royalty-free right to use such Background IP with a right to grant sublicenses to the extent necessary for Jagotec and its licensees and sublicensees to make unrestricted use of its Foreground IP;

  

	 	(ii)	in case Nitec IPR or Other IP is dependent on any or all Background IP of Jagotec (hereinafter referred to as “Dependent Nitec IPR”), Jagotec shall grant to
Nitec a non-exclusive, perpetual, royalty-free right to use such Background IP with a right to grant sublicenses to the extent necessary for Nitec and its licensees and sublicensees to make unrestricted use of its Foreground IP.

  

	4.3	Confirmation by Jagotec 

 Jagotec
hereby confirms that neither it nor any of its Affiliates currently own any patent or patent application not included in the term “Patents”, which is reasonably necessary or useful to develop, manufacture, sell or otherwise dispose of a
Product under this Agreement. Future Skye IPR which may be necessary to develop, manufacture, sell or otherwise dispose of a Product under this Agreement will be deemed added to Exhibit A on filing. 

 

	4.4	Prosecution of Patent Applications 

  

	(a)	 During the term of this Agreement, Jagotec shall use all Commercially Reasonable Efforts, at its own cost, to prepare, prosecute and maintain all
patent applications and patents constituting Patents, and shall keep Nitec fully and promptly informed on any developments or changes relating thereto. If Jagotec decides not to further prosecute or not to maintain any patent application
constituting Patents, Jagotec shall promptly inform Nitec of such decision in writing, and the Parties shall, upon Nitec’s written request, meet to discuss any 

 

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appropriate action taking into due consideration Nitec’s interests under this Agreement. 

  

	(b)	Nitec shall be responsible for and shall use all Commercially Reasonable Efforts to control, at its own cost, the preparation, prosecution and maintenance of all Nitec
IPR and shall keep Jagotec fully and promptly informed on any developments or changes relating thereto. During the term of this Agreement, Nitec shall, at its sole cost, take all steps necessary to prosecute and maintain all Nitec IPR to the extent
Nitec deems commercially reasonable. If Nitec intends not to further prosecute and/or maintain any of the Nitec IPR, Nitec shall promptly inform Jagotec of such intention in writing, and Jagotec shall meet with Nitec to discuss any appropriate
action taking into due consideration Jagotec’s interests under this Agreement. 

  

	4.5	Notification of Infringement 

  

	(a)	If Nitec becomes aware of (i) any product or activity of any kind that involves or may involve an infringement or violation of Skye IPR, or (ii) any
third-party action, claim or dispute (including, but not limited to, actions for declaratory judgment alleging the invalidity or non-infringement) based upon or arising out of Skye IPR, then Nitec shall promptly notify Jagotec in writing of any such
infringement, violation, action, claim or dispute. 

  

	(b)	If Jagotec becomes aware of (i) any product or activity of any kind that involves or may involve an infringement or violation of Skye IPR with respect to Product
or of Nitec IPR, or (ii) any third-party action, claim or dispute (including, but not limited to, actions for declaratory judgment alleging the invalidity or non-infringement) based upon or arising out of Skye IPR with respect to Product or of
Nitec IPR, then Jagotec shall promptly notify Nitec in writing of any such infringement, violation, action, claim or dispute. 

  

	4.6	Enforcement of Skye IPR 

  

	(a)	 Jagotec, at its sole expense, shall have the right, but not the obligation, (1) to determine the appropriate course of action to enforce, or
otherwise abate the infringement of, or defend third-party actions regarding, Skye IPR and its Background IP to the extent necessary for the Dependent Nitec IPR (hereinafter referred to as “Skye IPR plus Background”), (ii) to take, or
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appropriate action to enforce, or defend third-party actions regarding, Skye IPR plus Background, (iii) to control any litigation or other enforcement action regarding Skye IPR plus
Background, and (iv) to enter into, or permit, the settlement of any such litigation or other enforcement action regarding Skye IPR plus Background. Notwithstanding anything contained in the preceding sentence, Jagotec shall not settle any suit
or action or otherwise consent to an adverse judgement in such suit or action without Nitec’s prior written consent, which consent shall not be withheld unreasonably. Jagotec shall keep Nitec informed on a regular basis on its taking or
refraining from taking, and the development of, any of the foregoing actions, and shall consider, in good faith, the interests of Nitec under this Agreement when taking any of the foregoing actions. Nitec shall, at its own cost, fully cooperate with
Jagotec in the planning and execution of any suit or other action to enforce, or defend third-party actions regarding, Skye IPR plus Background to the extent affecting Product and as reasonably required by Jagotec. 

 

	(b)	If Jagotec does not within [...***...], or any shorter delay imposed by any applicable law or regulation or court or authority having jurisdiction, after
receiving notice of any infringement or violation of Skye IPR plus Background which may adversely affect Product, or of any third-party action, claim or dispute based upon or arising out of Skye IPR plus Background which may adversely affect
Product, commence or take an action to enforce, or otherwise abate such infringement, or defend against such third-party action, then the Parties shall, upon Nitec’s written request, promptly meet to discuss any appropriate action with regard
to such enforcement of Skye IPR plus Background which may adversely affect Product. 

  

	(c)	Nitec, upon its written request and at its sole expense, shall be made an additional, not controlling party in any such suit or other action where necessary to obtain
complete relief regarding the subject infringement or violation. 

  

	4.7	Enforcement of Nitec IPR 

  

	(a)	 Nitec, at its sole expense, shall have the right, but not the obligation, (i) to determine the appropriate course of action to enforce, or
otherwise abate the infringement of, or defend third-party actions regarding, Nitec IPR and its 

  

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Background IP to the extent necessary for the Dependent Skye IPR (hereinafter referred to as “Nitec IPR plus Background”), (ii) to take, or refrain from taking, appropriate action
to enforce, or defend third-party actions regarding, Nitec IPR plus Background, (iii) to control any litigation or other enforcement action regarding Nitec IPR plus Background, and (iv) to enter into, or permit, the settlement of any such
litigation or other enforcement action regarding Nitec IPR plus Background. Notwithstanding anything contained in the preceding sentence, Nitec shall not settle any suit or action or otherwise consent to an adverse judgment in such suit or action
without the prior written consent of Jagotec, which consent shall not be withheld unreasonably. Nitec shall keep Jagotec informed on a regular basis on its taking or refraining from taking, and the development of, any of the foregoing actions, and
shall consider, in good faith, the interests of Jagotec under this Agreement and in Skye IPR, when taking any of the foregoing actions. Jagotec shall, at its own cost, fully cooperate with Nitec in the planning and execution of any suit or other
action to enforce, or defend third-party actions regarding, Nitec IPR plus Background to the extent affecting Product and as reasonably required by Nitec. 

 

	(b)	If Nitec does not, within [...***...], or any shorter delay imposed by any applicable law or regulation or court or authority having jurisdiction, after
receiving notice of any infringement or violation of Nitec IPR plus Background, or of any third-party action, claim or dispute based upon or arising out of Nitec IPR plus Background, commence or take an action to enforce, or otherwise abate such
infringement, or defend against such third-party action, then the Parties shall, upon Jagotec’s written request, promptly meet to discuss any appropriate action with regard to such enforcement of Nitec IPR plus Background which may adversely
affect Product 

  

	(c)	Jagotec, upon its written request and at its sole expense, shall be made an additional, not controlling party in any such suit or other action where necessary to obtain
complete relief regarding the subject infringement or violation. 

  

	4.8	Application of Monies Recovered 

All monies recovered upon the final judgment or settlement of any suit or other action under these Sections 3.6 or 3.7 above shall be
applied as follows: 
  

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	 	(i)	firstly, to cover any and all costs and expenses (including attorney’s fees) incurred by the Party controlling such suit or other action; 

 

	 	(ii)	secondly, to cover any and all costs and expenses (including attorney’s fees) reasonably, or upon request of the controlling Party, incurred by the other Party in
connection with such suit or other action, if any; 

  

	 	(iii)	finally, the remainder, if any, to the Party controlling any such suit or other action. 

 

	5	Licence Grant 

  

	5.1	 Jagotec hereby grants to Nitec the royalty bearing exclusive and sub-licensable right and licence to market, distribute, sell, offer for sale and use
the Product in the Territory and to use the Patents, GEOMATRIX® Technology and Skye Know How exclusively for
that purpose. 

  

	5.2	 Furthermore, subject to the provisions of Section 6.2, Jagotec hereby grants to Nitec the option (the “Option”) to acquire the exclusive
and sublicenseable right and licence (hereinafter referred to as the “Nitec Manufacturing Licence “) to make or have made Product in the Territory and to use the Patents, GEOMATRIX® Technology and Skye Know How exclusively for that purpose at any time on twenty four month notice to expire no earlier than five years after the First Launch of the
Product in the Territory. The Option may be exercised in accordance with Section 6.2 below. For the avoidance of doubt, no royalty in addition to that set out in Section 7 shall be payable by Nitec to Jagotec in respect of the Nitec
Manufacturing Licence. The Nitec Manufacturing Licence shall be co-terminus with the licence granted under Section 5.1. 

  

	5.3	Subject to the provisions of Section 5.5, the rights of Nitec to grant any sub-license under the Licence and/or the Nitec Manufacturing Licence, as the case may
be, in any part of the Territory shall not require Nitec to receive the written approval of Jagotec. 

  

	5.4	 In any event, Nitec shall be responsible for any and all acts, deeds and undertakings of its sub-licensee(s) and shall continue to be bound by all
terms and provisions under this Agreement throughout its term. In case that Nitec sub-

  

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licenses rights and/or the Licence and/or the Nitec Manufacturing Licence, as the case may be, to any sub-licensee(s), such sub-licensee(s) shall agree in writing to any and all of Nitec’s
obligations and undertakings under this Agreement, including but not limited to its confidentiality obligations set out below. Furthermore, Nitec undertakes that any and all sub-licence agreements shall provide for inspection and audit provisions
identical to the provisions set forth below in order to enable Jagotec to control and audit and receive any and all Royalties due as provided in this Agreement. Nitec shall provide Jagotec promptly with appropriate information on its sub-licensee(s)
and, subject to applicable confidentiality restrictions, copies of all agreements with such sub-licensee(s). 

  

	6	Manufacturing and Product Liability 

  

	6.1	 Subject to the exercise by Nitec of its rights under Section 6.2, Jagotec shall exclusively manufacture, package and supply, or have manufactured,
packaged and supplied by an Affiliate, Product in bulk in accordance with the terms and conditions to be agreed upon in the Jagotec Manufacturing Agreement, which Jagotec Manufacturing Agreement shall contain provisions (i) that Nitec shall
supply to Jagotec or its Affiliate free of charge all Active Drug in quantities required for such manufacturing of Product, and (ii) on manufacture and packaging of Product in bulk and reimbursement of cost at [...***...] of
Jago’s fully allocated manufacturing cost therefore (calculated in substantially the same manner as Jago’s other manufactured products of similar production process, run and complexity) as required by the Parties. If Jagotec wants to have
the product manufactured, packed and supplied by an affiliate other than SkyePharma SAS, the costs of the manufacturing site change to such an affiliate (including but not limited to technical transfer, process validation, bioequivalence study and
regulatory expenses) shall be borne by Skye. Furthermore, the Jagotec Manufacturing Agreement shall contain provisions on lead times, order quantity and supply and purchase obligations of such quantities ordered (or part thereof), as may be mutually
agreed upon by the Parties and in the event of a failure by the Parties to agree by 31 March, 2005, each Party shall submit the matter to be resolved by an expert, to be appointed by

  

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a single arbitrator appointed under ICC Rules. With the exception of the principles applied in calculating the fully allocated manufacturing cost referred to above, in relation to any particular
proposed clause of the Jagotec Manufacturing Agreement on which the Parties are unable to agree, each Party shall propose terms, only one of which, subject to such amendments specified by the expert as shall be required to ensure that the Jagotec
Manufacturing Agreement operates as a whole, shall be selected by the expert as the relevant clause of the Jagotec Manufacturing Agreement binding on the Parties. In the case of the principles applied in calculating the fully allocated manufacturing
cost referred to above, the expert shall not be bound only to select terms proposed by one Party or the other as described above but shall be free to make such amendments to proposed terms as the expert shall think fit. 

 

	6.2	In the event that Nitec wishes to manufacture the Product under the Nitec Manufacturing Licence rather then having Jagotec manufacture the Product under the Jagotec
Manufacturing Agreement, then Nitec shall exercise its Option under Section 5.2 above by serving notice on Jagotec to that effect in writing. Subject to the proviso to this sentence, the right of Nitec under Section 5.2 shall not take
effect for a period of [...***...] months from the date of notice and during such period, (i) all pending orders for Product shall be satisfied by Jagotec in accordance with the Jagotec Manufacturing Agreement, and (ii) the Parties
will agree the terms of the royalty free Manufacturing Licence to include such provisions as are customary in the circumstances, failing which either Party may refer the matter to an expert for determination. Jagotec agrees that it shall provide
technical assistance in connection with such transfer to a third party manufacturer as set out in Section 3.4. The costs of the manufacturing site change (including but not limited to technical transfer, process validation, bioequivalence study
and regulatory expenses) shall be born by Nitec. Notwithstanding anything to the contrary contained herein, following exercise of the Option, the Manufacturing License shall be an irrevocable worldwide, fully paid-up, royalty-free license, pursuant
to which Nitec and its licensees shall have a right of sublicense. 

  

	6.3	 Nitec shall indemnify, defend and hold Jagotec and its Affiliates, directors, officers and shareholders harmless from and against any losses, claims,
liabilities, 

  

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costs and expenses (including reasonable attorney’s fees) that may be imposed upon or asserted against Jagotec and/or its Affiliates, directors, officers and shareholders as a result of the
manufacture of Product under the Manufacturing License, or the marketing, distribution, use or sale of Product under the License by or on behalf of Nitec, its Affiliates, agents or sub-licensee(s), except for those claims, liabilities, costs and
expenses arising from negligence or intentional misconduct on the part of Jagotec or its Affiliates and except for claims to the extent any relate to the Patents, GEOMATRIX® Technology and Skye Know How. 

  

	6.4	In the event that Jagotec wishes to cease to manufacture the Product under the Jagotec Manufacturing Agreement, Jagotec shall be permitted to do so by serving notice on
Nitec to that effect in writing. The termination under this Section 6.4 shall not take effect for a period of twenty four (24) months from the date of notice and in any event no earlier than five years after the First Launch of the Product in
the Territory and during such period all pending orders for Product shall be satisfied by Jagotec in accordance with the Jagotec Manufacturing Agreement. Jagotec agrees that it shall provide technical assistance in connection with transfer of
manufacturing rights to a third party manufacturer as set out in Section 3.4. The costs of the manufacturing site change (including but not limited to technical transfer, process validation, bioequivalence study and regulatory expenses) shall
be born by Nitec. 

  

	7	Royalties 

  

	7.1	In consideration of the License granted by Jagotec to Nitec hereunder, the royalty (the “Royalty”) payable by Nitec to Jagotec shall be:

  

	 	7.1.1	in the case of all countries of the Territory (other than North America): 

  

	 	(a)	[...***...] of Net Sales of Product in the Territory (other than North America), and 

 

	 	(b)	[...***...] of sublicensing income in the Territory (other than North America) being any payment not calculated based on Net Sales (to include, without
limitation, licence fees, lump sums and milestone payments.). 

  

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	 	7.1.2	in the case of North America: 

  

	 	(a)	[...***...] of Net Sales of Product in North America, and 

  

	 	(b)	[...***...] of sublicensing income in North America being any payment not calculated based on Net Sales (to include, without limitation, licence fees, lump sums
and milestone payments.). 

  

	7.2	All Royalties shall be payable on a quarterly basis. Nitec shall remit to Jagotec within [...***...] days after the end of each calendar quarter the amount of
Royalties, if any, due in respect of the preceding quarter, beginning with the calendar quarter in which the First Launch takes place. Nitec shall deliver to Jagotec, along with such remittance of Royalty payments a detailed statement (hereinafter
referred to as the “Royalty Report’) of Net Sales of Product and sublicensing income received on a country-by-country basis to which the Royalty payment relates. 

 

	7.3	All Royalty Reports shall be prepared in accordance with generally accepted accounting principles consistently applied from applicable period to period and shall be
certified by an officer of Nitec as being so prepared, true, accurate and correct. 

  

	7.4	Unless otherwise agreed by the Parties in writing, all payments of Royalties shall be made in EURO and to such place or account as Jagotec reasonably requests from time
to time in writing. Any conversions into EURO from the currency in which the corresponding Net Sales for such Royalties and sublicensing income were made, are to be calculated by using the average closing buying rate for such currency quoted in the
continental terms method of quoting exchange rates (local currency per EURO 1) published by the Financial Times on the last business day of the applicable reporting period covered by such Royalty Report. 

 

	7.5	 In the event that Nitec is required to withhold any tax to the tax or revenue authorities in the Territory regarding any payment to Jagotec, such
amount shall be deducted from the payment to be made by Nitec, and Nitec shall promptly notify Jagotec of such withholding and, within a reasonable amount of time after making such deduction, furnish Jagotec with copies of any tax certificate or
other documentation evidencing such withholding. Each Party agrees to cooperate 

  

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with the other Party in claiming exemptions from such deductions or withholdings under any agreement or treaty from time to time in effect. 

 

	8	Inspection and Audit 

  

	8.1	During the term of this Agreement and during a period of twelve (12) months after its expiration or termination for any reason, upon the written request of Jagotec
and not more than once each calendar year, Nitec shall permit an independent certified public accountant of internationally recognized standing selected by Jagotec, to have access during regular business hours to such of the records of Nitec and its
Affiliates and sub-licensee(s), if any, as may be reasonably necessary to verify the accuracy of the Royalty Reports for any year ending not more than twenty-four (24) months prior to the date of such request. The accounting firm shall disclose
to Jagotec only whether the Royalty Reports and records of Nitec and its Affiliates and sub-licensee(s), if any, and the amount of Royalties, if any, actually paid are correct or not and the specific details concerning any discrepancies; no other
information shall be shared. The Parties agree to accept such written audit report as final and binding upon them. 

  

	8.2	If such independent accounting firm correctly concludes that additional Royalties were owed during any such period audited, Nitec shall pay such additional Royalties
within thirty (30) days of the date Jagotec delivers to Nitec such accounting firm’s written report so concluding. The fees and expenses charged by such accounting firm with respect to such audit shall be paid by Jagotec, provided however,
if any such audit discloses that Royalties payable by Nitec for the audited period are more than [...***...] of the Royalties actually paid for such period, then Nitec shall pay all reasonable fees and expenses charged by such
accounting firm with respect to such audit. 

  

	8.3	Jagotec shall treat all financial information subject to review under this Section 7 as confidential and subject to the confidentiality obligations in Article 8
below. 

  

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	9	Confidentiality 

  

	9.1	During the term of this Agreement and in the course of the development work by Jagotec, it may be necessary for each Party to disclose to the other Party, orally or in
writing, certain of its Confidential Information, which each Party considers to be confidential and proprietary. Each Party agrees to hold in strict confidence and not to use, except for purposes of this Agreement, all Confidential Information
obtained from the other Party during the term of this Agreement. 

  

	9.2	The obligations of confidentiality and non-use contained in this Section 8 shall not extend and apply to Confidential Information that: 

 

	(i)	is in or enters the public domain without breach of this Agreement; or 

  

	(ii)	can be shown to have been known to the receiving Party prior to disclosure under this Agreement; or 

 

	(iii)	is disclosed to the receiving Party, without restriction, by a third party having the right to disclose the same; or 

 

	(iv)	is required to be disclosed by a judicial or administrative authority of competent jurisdiction or by law after maximum practical notice to the originally disclosing
Party. 

  

	9.3	Confidential Information of the other Party shall be disclosed or made available by the receiving Party only to those employees of the receiving Party who have a need
to know such Confidential Information for the purposes of this Agreement. Furthermore, the Parties may also disclose Confidential Information to consultants hired by one or both of the Parties, provided the receiving Party’s consultant has a
need to know such Confidential Information for purposes of this Agreement and has previously signed a written confidentiality agreement or has otherwise agreed to such confidentiality obligation with the receiving Party which contains substantially
the same obligations of confidentiality and non-use as set forth in this Section 8, and which is broad enough to cover disclosures of Confidential Information from the originally disclosing Party. 

 

	9.4	 In the event of termination or expiration of this Agreement for whatsoever reason, each Party shall immediately return to the other all of the other
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every and all copies made thereof save for one copy of each item of Confidential Information, which may be retained in the legal department or lodged with the legal advisers of the receiving
Party exclusively in order to provide a record of Confidential Information disclosed and to so determine each receiving Party’s continuing obligations hereunder. 

 

	9.5	The obligations of confidentiality and non-use contained in this Section 8 shall survive the expiration or termination of this Agreement for any reason for a
period of five (5) years commencing upon the effective date of such termination or expiration. 

  

	10	Term and Termination 

  

	10.1	Term and Expiration 

  

	(a)	This Agreement shall terminate on the later of ten (10) years from the Effective Date or on the expiry on a country-by-country basis upon the expiration of the
last to expire of the Patents in each country of the Territory, unless earlier terminated in accordance with Sections 10.2 and 10.3 below. 

  

	(b)	Upon the expiration of this Agreement in each country of the Territory pursuant to Section 10.1 (a) above and payment of all Royalties and Manufacturing
Royalties, if any, due under this Agreement, the License and the Manufacturing License, if applicable, shall be deemed to be a perpetual, fully paid-up and royalty-free license for Product in each such country of the Territory.

  

	10.2	Termination for Cause 

 During the entire term of
this Agreement either Party may terminate this Agreement by giving to the other Party written notice to that effect, if any of the following events occur: 
  

	(a)	the other Party is in default or in breach of a term or provision hereof and such default or breach is material and continues and is not remedied within
[...***...] upon the other Party’s written request to remedy such default or breach; 

  

	(b)	the other Party shall commit a material breach of any of the confidentiality provisions of Section 9 above; or 

 

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	(c)	the other Party goes into liquidation, voluntarily or otherwise, other than for the sole purpose of reorganization, or goes into bankruptcy or makes an assignment for
the benefit of creditors, or in the event of a receiver being appointed of the other Party’s property or parts thereof). 

  

	10.3	Termination prior to Registration 

In addition and not in limitation to Section 3.7 above, as from the Effective Date throughout the term until the first Registration
for Product is granted by any Regulatory Authority in any country of the Territory, this Agreement may be terminated as follows: 
  

	(a)	by either Party, if such Party reasonably considers based on a determination, in accordance with sound scientific, pharmaceutical and medical judgment, of the results
achieved with respect to the Product during the development phase, and that Party can demonstrate that there is a technical, pharmaceutical or medical problem regarding the Product, which would make the Product unapprovable in all of the following
countries, USA, UK and Germany, with [...***...] prior notice, provided that such terminating Party, prior to having the right to terminate this Agreement in accordance herewith, has in all detail disclosed such determination and the
underlying reasons to the other Party and has taken in due consideration any comments of the other Party on such determination; and 

  

	(b)	by Nitec, if the first application for Registration of Product or any material part thereof is finally rejected or denied, or if any Regulatory Authority in the
country, where the first Registration of Product is applied for, imposes restrictions on or conditions for the commercialization of the Product which have a material negative impact on the marketability of the Product, or if all Registrations of
Product in all countries are withdrawn or cancelled by the competent Regulatory Authorities, with [...***...] prior written notice. 

  

	10.4	Effect of Termination 

  

	(a)	 The termination of this Agreement shall be without prejudice to any rights and obligations of either Party accrued prior to the effective date of such
termination. Nitec shall forthwith make all payments due and outstanding to Jagotec at the date of termination. Except as explicitly otherwise stated in this Agreement, 

 

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Jagotec shall not be obliged to refund upon termination of this Agreement to Nitec any payments made by Nitec to Jagotec prior to such termination pursuant to the provisions of this Agreement.

  

	(b)	 In the event of termination of this Agreement pursuant to Sections 10.2 and 10.3 above, then this Agreement (and any agreements entered into in
connection with it) shall immediately be terminated and, except as provided herein, Nitec shall immediately refrain from using directly or indirectly in any way the Patents, GEOMATRIX® Technology and Skye Know-How. Upon termination of this Agreement, except as provided herein, Jagotec shall immediately refrain from using directly or indirectly in
any way all Nitec IPR as well as Nitec Know-How. Furthermore, each Party shall return to the other Party all Confidential Information (other than that relating to the Foreground IP of the other) received from or belonging to the other Party,
together with all copies thereof in such other Party’s possession or under its control, all free of any charge. Either Party shall have the right, but not the obligation, to use, at its sole discretion, any and all such material for its own
purposes. 

  

	(c)	 Subject to any rights of Merck under the Technology Transfer Agreement, in the event of termination by Jagotec under the terms of Section 3.3, the
terms of Section 10.4 (b) shall not apply and the Agreement (and any agreements entered into in connection with it) shall immediately be terminated and Nitec shall immediately refrain from using directly or indirectly in any way the
Patents, GEOMATRIX® Technology and Skye Know-How. At the same time, subject to any rights of Merck under the
Technology Transfer Agreement, Nitec shall grant to Jagotec the exclusive royalty free and, sublicenseable right and license to the Nitec IPR and the Nitec Know-How and any confidential information necessary or desirable for use with the Product in
the Territory and shall provide at no additional cost to Jagotec such information and documentation as shall be reasonably requested by Jagotec in that regard. 

 

	(d)	The termination for cause of this Agreement pursuant to Section 10.2 above by either Party shall not limit remedies which are or may be otherwise available in law
or equity to either Party. 

  

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	11	Representations and Warranties 

  

	11.1	 Jagotec represents and warrants that it shall carry out and undertake the development work until approval of the Product in the Territory in a careful
and diligent manner. Jagotec agrees to carefully choose, instruct and supervise any employees, officers, Affiliates or third parties to be chosen by it pursuant to this Agreement, who are involved in the Development of the Product. Nothing in this
Agreement shall be construed as a representation made, or warranty given, by Jagotec that any development performed by or for Jagotec under this Agreement will be successful in whole or in part, or that any product, including Product, which may be
developed, will be successful in the commercial marketplace. Furthermore, except as provided herein, Jagotec makes no representation or warranty, express or implied, with respect to GEOMATRIX® Technology and/or Skye Know-How, including without limitation, any warranty of completeness, accuracy, merchantability or fitness for a particular purpose.

  

	11.2	 Jagotec represents and warrants that it has all rights regarding Patents, GEOMATRIX® Technology and Skye Know-How necessary to grant the Licence and the Option and the Nitec Manufacturing Licence hereunder. Notwithstanding the preceding sentence but
subject to the following sentence, Jagotec does not assume any responsibility and makes no warranty that the performance of this Agreement and any product developed hereunder, including the Product, do not infringe any third party’s patents,
patent applications or other intellectual property rights. Notwithstanding the preceding sentence, Jagotec represents and warrants that, as of the Effective Date, it is not aware and has no knowledge of any such infringement of any third party
rights. If however, during the course of this Agreement either Party discovers that the Product infringes or may infringe any third party’s intellectual property rights, it shall promptly inform the other Party thereof and the Parties shall
meet to discuss the course of action to be taken with regard thereto. 

  

	11.3	Nothing in this Agreement shall be construed as a representation made, or warranty given by Jagotec that any patent will issue based upon any pending patent application
encompassed by the term Patents, and that any patent encompassed by the term Patents which issues will be valid or enforceable. 

  

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	11.4	Except as provided for in the Jagotec Manufacturing Agreement to be agreed upon in due time as referred to in Section 5.1 above, Jagotec assumes no liability or
responsibility for any damages caused to Nitec, third parties, and/or the environment by the manufacturing, marketing, distribution, sale or use of the Product or the Active Drug contained therein, except to the extent that any of the above are
attributable to the negligence or wilful misconduct of Jagotec in performing its obligations hereunder. 

  

	11.5	Nitec represents and warrants to strictly adhere at all times in all material respects to any and all laws, rules, regulations and conditions imposed by any competent
authority on the marketing, distribution and sale of Product, and Nitec shall during the entire term of this Agreement be solely and fully responsible for the compliance with all such laws, rules, regulations and conditions when marketing,
distributing and selling Product under the Licence. 

  

	11.6	Subject to the specific representations and warranties given and specific disclaimers of representations and warranties included in this Article 10, and further subject
to anything to the contrary contained in this Agreement, either Party shall, as to third parties, be indemnified and held harmless by the other Party from and against any and all losses, liabilities and damages arising from any claim, action or
other proceeding by any third party relating to any acts or omissions of the other Party, its directors, officers, employees or agents, or the gross negligence or wilful misconduct of such other Party, its directors, officers, employees or agents in
performing any of its obligations under this Agreement. 

  

	11.7	Any liability, warranty and undertaking contained herein shall be limited to the payment by either Party for direct damages to the other Party and in any event, neither
Party shall be liable to the other Party for any special, indirect, punitive or consequential damages and/or loss of profits or anticipated profits, respectively. 

 

	11.8	 Nitec shall, at its own expense, purchase from an insurance company of its choice and shall maintain during the entire term of this Agreement and
during [...***...] after its expiration or termination an appropriate and customary policy of general liability and product liability insurance covering its responsibilities, including in particular but without any limitation,
Nitec’s development responsibilities under Section 2 above, regarding Product developed, 

 

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manufactured, marketed, sold and used under this Agreement and the Active Drug contained therein and the use thereof. Upon request, Nitec shall provide Jagotec with evidence that such insurances
are existing and are maintained. 

  

	11.9	Nitec represents and warrants that, to the best of its knowledge and belief, having made due and careful investigation, it has acquired from Merck all relevant rights,
including but not limited to all relevant intellectual property rights of Merck in connection with the Merck Agreement to allow Nitec to carry out its obligations hereunder. Nitec shall indemnify Jagotec in respect of any breach thereof.

  

	11.10	Without prejudice and subject to the other terms of this Agreement, if Nitec determines that it requires a licence from a third party in order to manufacture, use,
sell, offer for sale or import the Product, including, without limitation, avoid infringement of any third party patent or in connection with settlement of any actual or threatened patent infringement claim, or if Nitec shall be subject to an order
or ruling of any court of competent jurisdiction requiring the payment of a royalty or other payment to a third party patent holder in respect of the manufacture, use, sale, offer for sale or import of the Product, then all such payments shall be
made at Nitec’s sole cost and expense. 

  

	12	Miscellaneous Provisions 

  

	12.1	Waivers: A waiver of a breach or default under this Agreement shall not be a waiver of any other or subsequent breach or default. The failure or delay by either Party
in enforcing compliance with any term or condition of this Agreement shall not constitute waiver of such term or condition, unless such term or condition is expressly waived in writing. 

 

	12.2	Headings: The titles and headings used in this Agreement are intended for convenience only and shall not in any way affect the meaning or construction of any provision
of this Agreement. 

  

	12.3	 Force Majeure: Neither Party shall be held in breach of this Agreement by any reason of acts or omissions caused by any Act of God or other causes
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diligence to remove any such causes and to resume performance under this Agreement as soon as it is reasonably feasible. 

 

	12.4	Assignment: Except as otherwise expressly stated herein, this Agreement and the rights and obligations hereunder shall not be assignable by either Party without the
prior written consent of the other Party, provided however, that either Party may, without such consent, assign this Agreement and its rights and obligations hereunder to an Affiliate of such Party, and in connection with the transfer or sale of all
or substantially all of its business, or in the event of its merger, consolidation, change in control or similar transaction. Any permitted assignee shall assume all obligations of its assignor under this Agreement so long as such assignee remains
liable on a joint and several basis for its obligations. 

  

	12.5	Separate Entities: Nothing in this Agreement shall constitute or be deemed to constitute a partnership between the Parties hereto or constitute or be deemed to
constitute either Party as an agent of the other for any purpose whatsoever, and neither Party shall have the authority or power to bind the other Party, or to contract in the name of and create a liability against the other Party in any way or for
any purpose, unless explicitly instructed in writing to do so. 

  

	12.6	Notices: All notices, reports and other writings which are required to be given or submitted pursuant to this Agreement shall be in writing and delivered personally or
sent by international courier service, or by confirmed facsimile transmission, to the addresses set forth below or to such other address as Jagotec or Nitec may from time to time notify to the other Party. Any and all notices sent to the other Party
in accordance with this Section 11.6 shall become effective as of receipt thereof by the other Party. 

 If to Skye,
SkyePharma or Jagotec: 
 Jagotec AG 

Eptingerstrasse 51 
 CH-4132 Muttenz, Switzerland

 Attn.: CEO 
 Fax: ++41-61-467-5574

  

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 with copy to: 
 SkyePharma PLC 
 105 Piccadilly 
 London W1J 7NJ 
 United Kingdom 
 Attn.: General Counsel 
 Tel.: +44-(0)20-7491-1777 

Fax: +44-(0)20-7491-3338 
 If to Nitec:

 Nitec Pharma AG 

Röschenzerstrasse 9 
 CH-4153 Reinach,
Switzerland 
 Attn.:Verwaltungsrat 

Fax: +41 61 711 46 39 
  

	12.7	 Severability: Each Party hereby acknowledges that it does not intend to violate any public policy, statutory or common laws, rules, regulations, treaty
or decision of any government agency or executive body thereof of any country or community or association of countries. Should one or more provisions of this Agreement be or become invalid, the Parties hereto shall substitute, by mutual consent,
valid provisions for such invalid provisions which valid provisions in their economic effect are sufficiently similar to the invalid provisions that it can be reasonably assumed that the Parties would have entered into this Agreement with such
provisions. In case such provisions cannot be agreed upon, the invalidity of one or several provisions of this Agreement shall not affect the validity of this Agreement as a whole, unless the invalid provisions are of such essential importance to
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the Parties would not have entered into this Agreement without the invalid provisions. 

  

	12.8	Interest: In the event any amount due and payable under this Agreement is not paid by the due date, then the Party owing such amount shall pay to the creditor, without
being requested by the other Party, interest on the total outstanding amount at the rate equal to the London Interbank Offered Rate (LIBOR), as published by the Financial Times on the date that such payment falls due, increased by
[...***...] in EURO and adjusted on the first day of every calendar quarter. 

  

	12.9	Entire Agreement: This Agreement, together with the Exhibits referred to herein and attached hereto, represents the entire understanding of the Parties with respect to
the subject matter hereof; and supersede all proposals or agreements, oral or written, and all other communications between the Parties related to the subject matter of this Agreement, including without limitation any representations or warranties
made by either Party hereto or its representatives. This Agreement may not be amended or modified except in a writing duly executed by the Parties. 

  

	13	Governing Law and Jurisdiction 

  

	13.1	The Parties hereto agree that this Agreement, including without limitation, all transactions affected hereunder, its validity and enforceability and all relationships
between the Parties in this connection shall be construed under and be governed in all respects by the laws of Switzerland without reference to the principles of conflicts of laws thereof and shall not be governed by the United Nations Convention on
Contracts for the International Sale of Goods (the Vienna Convention of April 11, 1980). 

  

	13.2	The Parties hereby agree that any and all disputes arising out of or in connection with this Agreement shall exclusively be submitted to and settled by the courts in
Zurich, Switzerland and the Parties hereby submit to such exclusive jurisdiction. 

  

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 This Agreement has been executed by Nitec and by Skye, by their duly authorized representatives, in
three (3) originals effective as of the Effective Date. 
  

									
	SKYEPHARMA AG	 		 		 	
					
	By:	 	/s/ Francesco Patalano	 		 	By:	 	/s/ Tessa Chapman
					
	Name:	 	Francesco Patalano	 		 	Name:	 	Tessa Chapman
					
	Title:	 	Director	 		 	Title:	 	Director
				
	JAGOTEC AG	 		 		 	
					
	By:	 	/s/ Francesco Patalano	 		 	By:	 	/s/ Tessa Chapman
					
	Name:	 	Francesco Patalano	 		 	Name:	 	Tessa Chapman
					
	Title:	 	Director	 		 	Title:	 	Director
				
	NITEC PHARMA AG:	 		 		 	
					
	By:	 	/s/ Dr. Hubertus Ludwig	 		 		 	
					
	Name:	 	Dr. Hubertus Ludwig	 		 		 	
					
	Title:	 	Verwaltungsrat	 		 		 	

  

 32. 

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***Confidential Treatment Requested 

  
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 ***Confidential Treatment Requested 

 34. 

 EXECUTION COPY 

 

													
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 ***Confidential Treatment Requested 

 35. 

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 ***Confidential Treatment Requested 

 36. 

 EXECUTION COPY 

 

													
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 ***Confidential Treatment Requested 

 37. 

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 ***Confidential Treatment Requested 

 38. 

 EXECUTION COPY 

 

													
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	 [...***...]
	 	[...***...]	 	[...***...]	 		 		 	[...***...]	 	[...***...]

  

 ***Confidential Treatment Requested 

 39. 

 EXECUTION COPY 

 

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	 	[...***...]	 	[...***...]	 		 		 	[...***...]	 	[...***...]

  

 ***Confidential Treatment Requested 

 40. 

 EXECUTION COPY 

 

 Exhibit B 
 Preliminary Specifications for Product 
 [...***...] 

 

			
	 Test
	 	 Specifications and Requirements

	 [...***...]
	 	[...***...]
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 Exhibit C 

Development Programme 
  

	-	[...***...] 

  

	-	[...***...] 

  

***Confidential Treatment Requested 

  
 41.

 EXECUTION COPY 

 

 Exhibit D 
 [...***...] 
  

 ***Confidential Treatment Requested 

 42.Lease Agreement

 Exhibit 10.21 
 ***Text Omitted and Filed Separately 
 with the Securities and Exchange
Commission. 
 Confidential Treatment Requested 
 Under 17 C.F.R. Sections 200.80(b)(4) 
 and 230.406. 

English Translation for Convenience 
 LEASE AGREEMENT 
 for rented commercial premises 

Between 
 Alters- und
Hinterbliebenen-Versorgungsstelle der 
 Technischen Überwachungsvereine VVaG 
 Kurfürstenstraße 58 
 45138 Essen 

- Lessor - 
 UST (turnover tax) ID: DE11 98
24807 
 and 
 Business name

 Nitec Pharma GmbH 
 - Lessee -

 UST (turnover tax) ID: 37009/52183 

the following agreement will be concluded: 

 LEASE AGREEMENT FOR OFFICE AND 

ADMINISTRATION SPACE 
 CONTENT and ANNEXES 
  

					
	 Page
	  	 Content

		
	1	  	Table of contents
			
	3	  	§1	  	 Leased Object

	3	  	§2	  	 Use of Leased Object

			
	4	  	§3	  	 Furnishing of the Rental Space

	4	  	§4	  	 Length of Lease, Termination

			
	5	  	§5	  	 Rent

			
	6	  	§6	  	 Turnover Tax

	6	  	§7	  	 Changes to Rent

			
	7	  	§8	  	 Payment of Rent

	7	  	§9	  	 Transfer and Condition of Leased Object

	7	  	§10	  	 Use by Third Parties

			
	8	  	§11	  	 Maintenance and Repair

	8	  	§12	  	 Insurance

			
	 8
	  	§13	  	 Signage/Advertising Property

	9	  	§14	  	 Surveillance and Security Systems

			
	 9
	  	§15	  	 Defects to Leased Object/Counterclaims

	 9
	  	§16	  	 Modifications to Leased Object Made by the Lessee

	 9
	  	§17	  	 Modifications to Leased Object Made by the Lessor

	1	  		  	
	 10
	  	§18	  	 Accessing and Entering the Leased Object

	 10
	  	§19	  	 Lessor's Lien/Provision of Security

			
	 11
	  	§20	  	 Termination of Lease

			
	 12
	  	§21	  	 Miscellaneous

			
	Annex I	  		  	 List of Operating Expenses and Service Charges

			
	Annex II	  		  	 Ground Plans of the Rental Space

 § 1 - Leased Object 

 

	1.1	The Lessor is the owner of the property, Joseph-Meyer-Straße 13-15, 68167 Mannheim, Germany. 

 

	1.2	 The Lessor shall lease office space totalling 171.18 sqm. on the 2nd floor of the building described above to the Lessee. This includes main floor
space and ancillary space and the associated public thoroughfares and floor space occupied by technical and building service installations. 

 The enclosed site plan is part of the Lease Agreement (Annex II). 
  

	1.3	If subsequent measurements of the rental space deviate from the floor space provided here, neither Party has the right to rescind this Agreement, to terminate this
Agreement or to demand a change in rent. The floor space indicated is to be taken as the basis whenever the size of the rental space is referred to in the provisions of this Agreement. 

 

	1.4	The space is being rented for use as an office. 

 Any changes in this type of use are only permissible upon obtaining written permission from the Lessor. In all cases, permission given by the Lessor shall be granted subject to first obtaining a required
official permit to change the type of use, even if the Lessor does not remind the Lessee of the need to do this at that time. The Lessee must acquire this permit at his own expense and present it to the Lessor. 

§ 2 - Use of Leased Object 
  

	2.1	The leased object shall be leased by the Lessee for the type of use specified in item 1.4. 

 

	2.2	The Lessor does not guarantee that the business the Lessee plans to conduct in the leased object is permissible according to public law. The Lessee must fulfill
numerous criteria at his own expense in relation to the conduct of his business for the duration of lease. The Lessee must comply with requirements imposed by the trade supervisory office or other authorities and do so regarding space-related
requirements as well. 

 The validity of this Lease Agreement is not contingent on an official permit permitting
the lessee’s business activities. 
  

	2.3	The Lessee undertakes to actively conduct his business and keep it open and operating in accordance with the type of business being conducted (contractual operation to
use, open or operate) for the duration of this Agreement. 

  

	2.4	The Lessor shall not grant the Lessee any protection against competition. 

 

 Page 3 of the Lease Agreement of December 21, 2004 

	2.5	The Lessee shall ask the Lessor for information about the load limit of the ceilings and obtain the Lessor's written approval before setting up machines, heavy objects
or other equipment in the rental space. The Lessee shall be liable for any damages that occur because of failure to comply with these provisions. If the Lessee's equipment as described above causes damage to the building (shaking, cracks, etc.) or
disturbances or has detrimental effects (e.g., noise, dust, disturbing smells, etc.) for other lessees of the building, the Lessor may revoke his approval and demand that the Lessee refrain from these activities. 

 

	2.6	Lease of the object shall include the right of free access to the leased object. 

 § 3 - Furnishing and Transfer of the Rental Space by the Lessor 
  

	3.1	The Lessee is aware of the current condition and layout of the leased object. 

 

	3.2	The leased object will be handed over to the Lessee by January 2005 at the latest. A record shall be made of the transfer. 

§ 4 - Length of Lease and Termination 
  

	4.1	Tenancy shall begin on January 1, 2005, and terminate after 1.5 years on June 30, 2006. section 568 of the German Civil Code (BGB) does not apply to the
Contracting Parties once tenancy has been terminated. 

  

	4.2	Ordinary notice of termination shall be excluded for the duration of tenancy. The right of both Parties to immediate termination without notice for good cause shall
remain unaffected. The right of the Lessor to effect immediate termination without notice applies particularly when: 

  

	 	a)	the Lessee is behind by more than one month's rent or has not provided the security agreed to in the amount, period of time and means stipulated in the Agreement;

  

	 	b)	the Lessee makes structural changes to the leased object or to parts thereof without first obtaining the Lessor's permission or uses it for purposes other than those
stipulated in the Agreement, in particular subletting it to third parties; 

  

	 	c)	the Lessee ceases payment, it comes to legal or out-of-court settlement or bankruptcy proceedings regarding his assets or he is required to make an oath regarding his
assets; 

  

 Page 4 of the Lease Agreement of December 21, 2004 

	 	d)	if the Lessee fails to comply with the terms of contract despite two written warnings regarding the same. 

 

	4.3	The Lessee has the option to extend the Lease Agreement by one, two or three years once the term of the Lease Agreement as specified under item 4.1 has expired. If the
Lessee chooses to exercise this option, he shall notify the Lessor of this decision in writing 6 months prior to expiration of tenancy. The Agreement shall be terminated 6 months prior to the relevant date of expiration. 

 

	4.5	If the Lessee is a natural person, the right of early termination pursuant to section 569 of the German Civil Code (BGB) shall hereby be excluded.

 § 5 - Rent 
  

	5.1	Rent for the basic leasing period from January 1, 2005, until June 30, 2006, shall be calculated as follows: 

 

									
	 Office space
	  	171.18 sqm	  	X	  	[...***...]	  	[...***...]
	 3 underground parking spaces
	  		  		  		  	[...***...]
	 Advance payment of service charges
	  	171.18 sqm	  	X	  	[...***...]	  	[...***...]
		  		  		  		  	 
					
	 Subtotal, net
	  		  		  		  	[...***...]
	 16 % value-added tax
	  		  		  		  	[...***...]
		  		  		  		  	 
					
	 Gross total
	  		  		  		  	[...***...]
		  		  		  		  	 

 If the Lessee decides to exercise the option stipulated
in item 4 for one year, the rent in the amount of [...***...] shall remain the same. For a two-year duration, rent shall be reduced to [...***...] per sqm and to [...***...] per sqm for a duration of three years. 

 

	5.2	In addition to basic rent, the Lessee shall pay all operating expenses for the leased object that are attributed directly to him (e. g., electricity, gas, water,
telephone and other communications expenses) as well as all of the building operating expenses and service charges. Operating expenses and service charges comprise all costs listed in Annex I of this Agreement as well as any costs that may
arise in the future, having been newly introduced for the leased object by law, regulation, by-law or for any other reason. The list of operating expenses and service charges pursuant to Annex I is therefore an example and not a final listing of all
possible costs. 

  

	5.3	The Lessor shall apportion these operating expenses and service charges to the Lessee and settle these with him. If there are several lessees in the building, the
Lessor shall determine how these costs should be distributed (distribution legend) to the extent he is required to do so by legal provisions and shall do so in accordance with these provisions. The distribution legend shall be based on the share of
leased space from the total area. 

  

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	5.4	The Lessor shall invoice these expenses annually by December 15th of the following year at the latest. Should tenancy end during a billing period, the expenses
shall be invoiced within the scope of the following annual accounting activities. 

  

	5.5	If operating costs increase or can be reasonably expected to increase (e. g., due to notification of an increase in local charges), the Lessor has the right to demand a
corresponding increase in the advance payments. 

 § 6 - Turnover Tax 

 

	6.1	In addition to the stipulated basic rent including operating expenses and service charges, the Lessor shall pay turnover tax as it falls due as prescribed under law.
The Lessee guarantees that he intends to use the rental space exclusively for generating turnover which does not exclude the Lessor from deducting input tax. If the Lessee does not use the rental space exclusively to generate profit that does not
exclude input tax deduction as promised (use having negative tax effects), basic rent including service charges shall increase for the period of use having negative tax effects by whichever amount is equal to the basic rent plus operating expenses
and service charges for the turnover tax paid. 

  

	6:2	Upon the Lessor's request, the Lessee shall provide proof that he is using the leased object solely to generate profit that does not exclude input tax deduction. The
Lessee shall immediately inform the Lessor before he starts using the leased object for use having negative tax effects and compensate the Lessor for any damage that may arise due to the Lessee violating his obligation to give notice; this
particularly includes damage caused to the Lessor by paying turnover tax to the internal revenue service after the leased object has begun to be used for purposes having negative tax effects, even though lease of the object is at that time no longer
subject to turnover tax. Claims for damages of this nature shall not become statute-barred until 6 months after a tax authority or tax court has determined that the Lessor does not or no longer has the right to input tax deduction.

 § 7 - Changes to Rent 
  

	7.1.	If the price index determined by the German Federal Statistics Office for the standard of living for all private households (consumer price index for Germany) (base
year 2000 = 100 points) changes as compared to its state as of June 30, 2009, or as compared to the last adjustment of rent by more than [...***...], the basic rent stipulated in item 5 shall be proportionally modified accordingly.
Changes shall become effective on the first day of the month in which the change has been made. 

  

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	7.2.	 If this adjustment clause cannot be considered approved pursuant to item 4 of the price clause decree, the Parties undertake to agree on an adjustment
clause that comes as close as possible to the commercial concept and purpose of the original clause which can be approved according to the provisions valid at that time. 

 § 8 - Payment of Rent 
 Payment of rent shall begin on January 1,
2005. 
 Rent is due by the 3rd business day of each month at the latest and shall be paid to the following account:
[...***...]. 
 § 9 - Transfer of Leased Object / Condition of Leased Object 

 

	9.1	Transfer of the leased object is scheduled to take place at the start of the rental period pursuant to item 4.1. The Lessor shall notify the Lessee of the official
transfer date in writing as soon as possible. 

 Any work that still needs to be done, e. g., complete provision of
outdoor facilities and/or repair of defects, shall not prevent transfer of the leased object. 
  

	9.2	The Parties shall make a record of the transfer at the time of transfer documenting the condition of the leased object as well as any defects present at that time.

 The Lessor shall repair any defects identified in the record of transfer within a reasonable amount of time.

 § 10 - Use by Third Parties 
  

	10.1	Any partial or complete use by third parties, particularly subletting the leased object, requires the Lessor’s prior consent. The Lessee shall not have the right
to terminate the lease should the Lessor not give his consent. The Lessee shall be responsible for and bear the costs of meeting any conditions stipulated by the authorities within the scope of such transfer of use so that the leased object can be
used for other purposes that have been approved by the Lessor. 

  

	10.1	The Lessor may revoke his approval of a subletting arrangement for good cause. However, this may not be done at an inopportune time. 

 

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 § 11 - Maintenance/Repairs/Decorative Repairs/Liability for Damages 

 

	11.1	The Lessee shall be responsible for decorative repairs as well as other maintenance and repair work inside the rental space as well as any damage caused by lessee use
(wear and tear, deterioration, damage caused by the Lessee or his helpers). 

 §12 - Insurance 

 

	12.1	Standard building insurance (fire, storm, damage from mains water, extended coverage) and premises liability insurance shall be concluded by the Lessor and billed
together with the operating expenses and service charges. The installation of any fixtures in or additions or renovations to the leased object conducted by the Lessee shall not be covered by the building insurance. The Lessee shall be obliged to
obtain insurance for these fixtures, additions or renovations at his own cost. 

  

	12.2	The Lessee shall be obliged to obtain sufficient business liability insurance as well as insurance covering breaking and entering as well as theft and sufficient
insurance against any damage to equipment and objects brought into the leased object at his own expense and to maintain these insurance policies for the length of the lease. 

 

	12.3	The Lessor has the right to view the insurance contracts as proof that the Lessee has obtained the insurance policies listed under item 12.2 and that these are being
maintained. This also applies to payment of the first premium for each insurance policy. 

 § 13 - Signage/Advertising

  

	13.1	The Lessee shall be permitted to place nameplates and company signs in the entrance area and at the doors to the rented rooms in those places designated by the Lessor
for this purpose. Other building sections or areas of the property are not part of this lease; advertising installations, vending machines, display windows, stands, signs, awnings, antennae, etc., may therefore not be installed or set up.

  

	13.2	Any additional advertising installations or materials pursuant to item 13.1 that the Lessee wishes to install or set up shall require the Lessee to obtain the Lessor's
written, prior consent, which may involve conditions and expenses to be paid by the Lessee. 

  

	13.3	The Lessor shall reserve the right to make sure that signage or any advertising or other installations are designed in accordance with a joint advertising concept for
the property. The Lessee must adjust his signage and advertising and other installations so that they correspond to this uniform concept. The Lessee shall bear the costs for signage. 

 

 Page 8 of the Lease Agreement of December 21, 2004 

 § 14 - Property Surveillance and Security Systems 

 

	14.1	Should the Parties deem surveillance measures necessary for the property, the Lessee shall tolerate these to the extent he is notified of said measures in due time. The
Lessee shall be obliged to bear any costs incurring with respect to this matter. If there are several lessees, these costs shall be divided among them in accordance with the scale used for other operating expenses and service charges.

  

	14.2	This shall also apply should the Lessor install security systems. Installation of security systems inside the premises by the Lessee shall require the prior consent
from the Lessor. 

 § 15 - Defects to Leased Object/Counterclaims 

The legal provisions shall apply. 
 § 16 - Modifications to Leased Object made by the Lessee 
  

	16.1	Modifications made to and in the leased object, particularly rebuilding, fixtures, installations and similar modifications, may only be made after obtaining written
consent from the Lessor. 

  

	16.2	Gas, electronic and other devices may only be hooked up to the available supply network to an extent that does not exceed the usage limit designated for the leased
object. 

 § 17 - Modifications to Leased Object made by the Lessor 

 

	17.1	The Lessor shall have the right to make repairs and structural changes that become necessary or are advisable for maintenance, to avoid possible hazards, repair damages
or improve the leased object and rental thereof even without the Lessee's consent. The Lessee shall make sure that the affected rooms and space are accessible and may not prevent or delay completion of the work; should he do this, the Lessee shall
pay for any damage that arises. 

  

	17.2	The Lessor shall make allowances for the Lessee's business affairs. In particular, the Lessor shall inform the Lessee of such work in due time. This obligation to
inform the Lessee shall not apply in the case of imminent danger. 

  

 Page 9 of the Lease Agreement of December 21, 2004 

 § 18 - Accessing and Entering the Leased Object 

The Lessee shall guarantee that the Lessor or his agents, experts or interested parties are able to enter and view the leased object at
any time during standard business hours for the purposes of re-letting, sale, assessing the condition of the leased object or doing work on the leased object, if the Lessee has been notified in advance. 

The Lessee shall guarantee that the leased object can be accessed and entered at any time of day or night in the case of imminent danger.

 § 19 - Lessor’s Lien / Provision of Security 

 

	19.1	The Lessor has a lessor’s lien on items brought into the leased object by the Lessee (office furniture, machines and other objects for business use and furnishing)
for all present and future claims under this Agreement. 

  

	19.2	If third parties pledges items brought into the leased object by the Lessee, the Lessee shall be obliged to immediately notify the Lessor of the details and scope of
the pledge by providing him with the relevant documents. 

  

	19.3	At least 14 days prior to the commencement of the lease pursuant to section 4.1 the Lessee shall provide security (guarantee) in the amount of [...***...]
rent plus the agreed or estimated operating expenses and service charges as well as the applicable value-added tax in the amount of 

 [...***...] 
 [...***...] 

as security for all the Lessor's claims under this Agreement and its termination. 

(Translator’s note: The amount indicated in numbers and that indicated in words do not correspond in the original document and
have therefore been translated as such.) 
 Security shall be provided in the form of an unconditional, irrevocable and
unlimited guarantee for which the Lessee is liable as the sole principal from a major bank headquartered in the Federal Republic of Germany for which the guaranteeing bank shall waive the right to appeal, to offset and to deposit and the rights and
objections from sections 768 and 776 of the German Civil Code (BGB) and which is obligated to pay on the first request to do so by the Lessor. 
 The guarantee may not contain any further conditions or limitations beyond the provision that the guarantee obligation shall be returned, if the Lessor returns the bank guarantee to the guarantor or if
the lease is terminated and all of the Lessee's obligations arising from said lease have been fulfilled, if applicable reduced by the amount claimed by the Lessor. 

 

 Page 10 of the Lease Agreement of December 21, 2004 

 

			
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	19.4	In the event changes are made to basic rent during tenancy and/or to the operating expenses and service charges by at least [...***...] of the previous monthly
total, the Lessee shall be obliged to adjust his provision of security accordingly, if requested to do so by the Lessor within 14 days of receiving said request. 

 § 20 - Termination of Lease 
  

	20.1	Once lease has been terminated, the Lessee shall return the leased object cleaned and in suitable condition together with all keys to the Lessor. The Lessee shall also
conduct any necessary decorative repairs, maintenance and other repairs that he is obligated to conduct pursuant to section 11 until the end of the lease; should the Lessee fail to do so, the Lessor may conduct such repairs and measures himself
instead of the Lessee at the Lessee's cost without reminding the Lessee that he is obligated to make such repairs. 

  

	20.2	Objects that the Lessee has placed in the leased object and any changes made by him to the leased object during the lease, particularly fixtures and renovation,
including signage, advertising installations and other installations in accordance with item 13 of this Agreement must be professionally removed and the original state of the lease object needs to be established by the Lessee.

 The Lessee shall not remove the cabling, the built-in server room and the air conditioning unit located in the
server room present in the premises at the commencement of the lease, after moving out of the leased object. 
 The Lessor may
avert the exercise of this right to remove an article by paying suitable compensation based on the current value of the object. 
  

 Page 11 of the Lease Agreement of December 21, 2004 

 

			
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 § 21 Miscellaneous 

 

	21.1	Place of fulfillment and court of jurisdiction for all obligations in connection with this Agreement shall be Mannheim, Germany. 

 

	21.2	Should one or more provisions of this Agreement be invalid, this shall not affect the validity of the other provisions. The Parties shall replace the invalid provision
by an effective provision with retroactively effect, on which they would reasonably have agreed had they previewed the invalidity or absence of the respective provision. 

 

	21.3	Supplementary agreements, changes, additions and cancellation of the Agreement are only effective if conducted in writing. This also applies to any kind of permission
or consent. The written form requirement may only be waived expressly and in written form. In particular, any declarations arising within the scope of this Agreement such as cancellations, consent, permits and similar declarations shall be made in
writing to be effective. 

  

	21.4	The built-in server room in the offices, including technical installations (e.g., additional cabling, air conditioning unit) as well as the additional door closing
system including installations shall remain in the premises after the Lessee has moved out. 

  

	21.5	Reference shall be made to the Annexes I - II associated with this Agreement. 

 

							
	Essen, January 6, 2005	 		 	Munich, December 22, 2004
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]     [Illegible Signature]

	(Lessor)	 		 	(Lessee)

  

 Page 12 of the Lease Agreement of December 21, 2004 

 Annex I to the Lease Agreement AHV / Nitec Pharma 
 LIST OF OPERATING EXPENSES AND SERVICE CHARGES 
 The following running costs that are
incurred by the owner due to his ownership of the property or due to the intended use of the building or the economic unit, the adjoining buildings, facilities, installations and property, unless they are usually borne directly by the Lessee in
addition to the rent, constitute the operating expenses and service charges: 
  

	1.	Current public rates and charges for the property 

 These namely comprises the land tax. 
  

	2.	Costs for water supply 

These comprise the costs for water consumption, basic charges and charges for renting meters, costs for using intermediate meters as well
as operating costs. 
  

	3.	Drainage costs 

 These
comprise the charges for use of a public drainage system, including discharge of rainwater as well as operating costs. 
  

	4.	Heating system costs 

These comprise the operating and cleaning costs 
  

	 	a)	for the heating system as well as the costs for using measuring equipment to measure consumption. Heating systems may, for example, be central heating systems or
heating systems connected to the hot water supply system, central fuel supply systems or floor heating systems 

  

	 	b)	costs for district heating and operating costs 

  

	 	c)	costs for reading and analysis of the equipment to measure consumption. 

  

	5.	Costs of hot water supply 

These include the operating and cleaning costs for 
  

	 	a)	hot water supply facilities, such as central hot water supply facilities or hot water supply facilities connected to the heating system; 

 

	 	b)	costs for supplying with district hot water and operating costs for the associated facilities in the building; 

 

 Page 1 of the Annex I to the Lease Agreement of December 21, 2004 

	 	c)	hot water units and equipment to measure consumption; 

  

	 	d)	costs for reading and analysis of the equipment to measure consumption. 

  

	6.	Costs for air conditioning and ventilation systems 

 These comprise the operating costs. 
  

	7.	Costs for the passenger elevator or freight elevator 

 These comprise the costs for the operational electricity, supervision costs, service costs, costs of monitoring the installation and maintenance costs, costs for regularly checking it for operational
readiness and operational safety, including adjustment by an expert and cleaning costs. 
  

	8.	Costs for street cleaning and garbage disposal 

 These comprise the fees to be paid for public street cleaning and garbage disposal as well as the costs for corresponding non-public measures. 

 

	9.	Costs for cleaning and pest control 

 Cleaning costs include, among others, costs for cleaning the property, in particular access and entrance areas, corridors, staircases, basements, attic spaces, laundry rooms, technology rooms, lift cages
and facades as well as costs for glass cleaning. 
  

	10	Costs for outside facilities 

 These comprise costs for horticultural upkeep and ground maintenance, including replanting of plants and trees and the upkeep of playgrounds, including replacing sand. These also include upkeep, cleaning,
snow removal and strewing sand or other suitable material in areas, access areas and driveways that are not used for public traffic. 
  

	11.	Lighting costs 

 These
comprise the electricity costs for outdoor lighting and the indoor lighting of general building sections, such as access and entrance areas, corridors, staircases, basements, attic areas, laundry rooms and technology rooms. 

 

 Page 2 of the Annex I to the Lease Agreement of December 21, 2004 

	12.	Costs of cleaning pipes and chimneys 

 These comprise fees for cleaning pipes and chimneys pursuant to the applicable list of fees. 
  

	13.	Insurance costs 

 These
comprise the costs for all insurance policies that have been taken out for the object, such as building insurance with all-risk coverage, glass insurance, liability insurance for the building, the oil tank and the elevator as well as insurance
against loss of rent. 
  

	14.	Costs for the janitor, porter or doorman and all other staff required for building operation 

These include, inter alia, ancillary labor costs and special remuneration. 

 

	15.	Costs for signage and advertising installations 

 These comprise costs for installing and operating signs and advertising installations. Signage comprises business name, name, location and information signs. 

 

	16.	Property management costs 

These comprise the costs for property management with technical and commercial support. 

 

	17.	Costs for a lightning protection system 

  

	18.	Costs for parking facilities 

 These comprise costs for operating, cleaning and maintenance of parking facilities. 
  

	19.	Operational electricity costs 

 These comprise operational electricity costs for the common building sections and facilities, to the extent they are not borne by the users themselves or are included in the above-mentioned items.

  

	20.	Maintenance costs 

 These
comprise the costs for all maintenance work carried out on the property that are not included in the above-mentioned items. 
  

 Page 3 of the Annex to the Lease Agreement of December 21, 2004 

	21.	Other public charges 

  

	22.	Costs 

 of operation

  

	 	a)	of the common aerial system or 

  

	 	b)	the private distribution system connected to a broadband cable network or 

  

	 	c)	of the satellite reception equipment 

  

	23.	Costs for property surveillance and security installations 

 These comprise the costs for regular and special monitoring and surveillance measures as well as the costs for manufacturing, installing and operating security installations. 

 

	24.	Costs for other equipment 

These include operating costs such as those for washing machine and dryer facilities. 

 

	25.	Costs for property service charge accounts 

 These comprise the capital cost for the property service charge accounts, including bank service charges, account-keeping fees, interest charges. 

 

	26.	Other operating costs 

These comprise the operating costs not mentioned in clause 1 to 25, namely operating costs for adjoining buildings, facilities and
installations. 
  

					
	Essen, January 6, 2005	 		 	Mannheim, December 22, 2004
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]    [Illegible Signature]

	(Lessor)	 		 	 (Lessee)

	 Alters- und Hinterbliebenen-Versorgungsstelle
 der Technischen Überwachungs-Vereine (VVaG)
 Kurfürstenstraße 56

45138 Essen
	 		 	

  

 Page 4 of Annex I to the Lease Agreement of December 21, 2004 

 

 

  

 Addendum No. 1 to the Lease Agreement of January 6, 2005/December 22, 2004

 Object: Janus-Office-Center, 
 Josef-Meyer-Str. 3-15, D- 68167 Mannheim, Germany 
 between 

Alters- und Hinterbliebenen Versicherung der 

Technischen Überwachungsvereine VVaG 

Kurfürstenstr. 56 
 45138 Essen, Germany

 UST ID: DE 11 98 24807 
 represented
by its managing executive board member, Dr. rer. pol. G. Wiedemann, 
 and 
 the company 
 Nitec Pharma GmbH 
 Joseph-Meyer-Str. 13-15 
 68167 Mannheim, Germany, 

represented by its general manager, Mr. Jochen Mattis 
 - hereinafter referred to as the “Lessee” - 
  

	1.	Amendment of § 1 Rental Property (Translator’s note: Item 1 of the Lease Agreement is called “Leased Object” and not “Rental
Property”.) 

 The rental space shall be extended by 57.65 sqm on the second floor. The ground plan is
attached as Annex 1 to this Addendum. 
  

	3.	Amendment of § 4 Rent, Service Charges and Value-added Tax 

 As of February 1, 2006, the rent for the second floor shall be composed of the following: 
  

									
	 Presently occupied office space
	  	171.18 sqm	  	x	  	[...***...]	  	[...***...]
	 New office space
	  	57.65 sqm	  	x	  	[...***...]	  	[...***...]
	 4 underground parking spaces
	  		  		  		  	[...***...]
	 Advance payment of service charges
	  	228.83 sqm	  	x	  	[...***...]	  	[...***...]
		  		  		  		  	 
					
	 Net sub-total
	  		  		  		  	[...***...]
	 16%VAT.
	  		  		  		  	[...***...]
		  		  		  		  	 
	 Total sum gross
	  		  		  		  	[...***...]

  

 Page 1 of the Addendum of December 7, 2005 

 

			
		 	***Confidential Treatment Requested

	4.	Miscellaneous 

  

	 	1.	The Lessor shall bear the costs for the relocation of electricity and server cables as well as for the fitting of carpet in the newly rented premises.

 The Lessee shall bear the costs for moving the walls. 

 

	 	2.	All other provisions of the main Lease Agreement of January 6, 2005/ December 22, 2004, shall remain in force without change. 

 

					
	Essen, January 30, 2006	 		 	Mannheim, January 13, 2006
			
	Alters- und Hinterbliebenen Versicherung	 		 	Fa. Nitec Pharma GmbH
	der Technischen Oberwachungsvereine VVAG	 		 	Joseph-Meyer-Str. 13-15
	Kurfürstenstr. 58	 		 	68167 Mannheim
	45138 Essen	 		 	
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Lessor)	 		 	(Lessee)
	[stamp: Alters-und Hinterbliebenen-Versicherung] [stamp: Fa. Nitec Pharma GmbH]

 

 Page 2 of the Addendum of December 7, 2005 

 

 

 Annex to the Addendum 

 Addendum No. 2 to the Lease Agreement of January 6, 2005 / December 22,
2004 
 Object: Janus-Office-Center, 
 Josef-Meyer-Str. 13-15, 68167 Mannheim 
 between 

Alters- und Hinterbliebenen Versicherung der 

Technischen Überwachungsvereine VVaG 

Kurfürstenstr. 56 
 45138 Essen, Germany

 UST ID: DE 11 98 24807, 

represented by its executive board, Dr. rer. pol. G. Wiedemann, and Mr. Ralf Heynck, 
 and 
 the company 
 Nitec Pharma GmbH 
 Joseph-Meyer-Str. 13-15 

68167 Mannheim, Germany, 
 represented by its
managing director, Dr. Achim Schäffler 
 - hereinafter referred to as the “Lessee” -

  

	1.	Amendment to § 1 Rental Property 

 As o February 1, 2007, the rental space on the second floor shall be expanded by 214.17 sqm. The Lessee will thus occupy the complete second floor. The overall space will amount to 443 sqm.

  

	2.	Amendment to § 4 Term of Lease and Termination 

 As of February 1, 2007, the lease for the complete second floor shall be extended by another two years until January 31, 2009 [changed Jaas] 

 

	3.	Amendment to § 5 Rent 

As of February 1, 2007 the rent fort he second floor is composed as follows: 

 

									
	Basic rent for the office space on the 2nd floor	  	443.00 sqm	  	x	  	[...***...]	  	[...***...]
	Underground parking spaces 125, 126,127,128	  		  		  		  	[...***...]
	Parking spaces No. 33+32	  		  		  		  	[...***...]
		  		  		  		  	 
	Basic rent total	  		  		  		  	[...***...]
	Advance payment of service charges	  	443.00 sqm	  	x	  	[...***...]	  	[...***...]
		  		  		  		  	 
	Net total: rent including heating	  		  		  		  	[...***...]
	 + 19% VAT
	  		  		  		  	[...***...]
		  		  		  		  	 
	 Total amount
	  		  		  		  	[...***...]
		  		  		  		  	 

  

 Page 1 of the Addendum No. 2 AHV/Nitec 

 

			
		 	***Confidential Treatment Requested

	4.	Miscellaneous 

  

	 	1.	The Lessee shall bear the costs for the installation of the electricity and server cables as well as for the demolition of the added wall. 

 

	 	2.	The Lessor shall bear the costs for the fitting of carpet in the newly rented premises. 

 

	 	3.	All other provisions of the main Lease Agreement of January 6, 2005/ December 22, 2004, shall remain in force without change. 

 

							
	Essen,	 	  
	 		 	Mannheim, January 3, 2007
			
	Alters- und Hinterbliebenen-Versicherung der	 		 	Fa. Nitec Pharma GmbH
	Technischen Überwachungs-Vereine VVaG	 		 	Jpseph-Meyer-Str. 13-15
	Kronprinzenstr. 30	 		 	
			
	45128 Essen	 		 	68167 Mannheim
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Lessor)	 		 	(Lessee)

  

 Page 2 of the Addendum No. 2 AHV/Nitec 

 Addendum No. 3 to the Lease Agreement of January 6, 2005 / December 22,
2004 
 Object: Janus-Office-Center, 
 Josef-Meyer-Str. 13-15, 68167 Mannheim 
 between 

Alters- und Hinterbliebenen-Versicherung der 

Technischen Überwachungs-Vereine VVaG 

Kronprinzenstr. 30 
 45128 Essen 

UST ID: DE 11 98 24807, 
 represented by the
executive board, Dr. rer. pol. G. Wiedemann, and Mr. Ralf Heynck, 
 - hereinafter referred to as the “Lessor” - 

and 
 the company 

Nitec Pharma GmbH 
 Joseph-Meyer-Str. 13-15

 68167 Mannheim 
 represented by its
managing director, Dr. Achim Schäffler, 
 - hereinafter referred to as the “Lessee” - 

 

	1.	Amendment to § 1 Rental Property 

 As of April 1, 2008, the rental space shall be expanded by 247.29 sqm on the sixth floor. 
 Thus, the floor space will amount to a total of 690.29 sqm (second and sixth floor). 
  

	2.	Amendment to § 5 Rent 

As of April 1, 2008, the rent shall be composed of the following: 

 

											
	 Basic rent office space on the 2nd floor
	  	443.00 sqm	  	x	  	[...***...]	  	=	  	[...***...]
	 Basic rent for the office space on the 6th floor
	  	247.29 sqm	  	x	  	[...***...]	  	=	  	[...***...]
	 Underground parking spaces 125,126,127,128,132,133
	  		  		  		  		  	[...***...]
	 Parking spaces No. 32+33+10+11+2
	  		  		  		  		  	[...***...]
		  		  		  		  		  	 
	 Basic rent total
	  		  		  		  		  	[...***...]
	 + Advance payment of service charges
	  	690.29 sqm	  	x	  	[...***...]	  	=	  	[...***...]
		  		  		  		  		  	 
	 Net total: rent including heating
	  		  		  		  		  	[...***...]
	 + 19% VAT
	  		  		  		  		  	[...***...]
	 Total amount
	  		  		  		  		  	[...***...]
		  		  		  		  		  	 

  

 Page 1 of the Addendum No. 3 AHV/Nitec 

 

			
		 	***Confidential Treatment Requested

	4.	Miscellaneous 

  

	 	1.	The Lessee shall bear the costs for the paintwork and the cleaning of the carpet in the offices on the sixth floor. 

 

	 	2.	The Lessor shall replace the carpet in those offices in which the carpet is heavily worn out. 

 

	 	3.	The Lessor shall bear the costs for a dishwasher. 

  

	 	4.	The furniture on the sixth floor shall be transferred to the company Nitec Pharma free of charge. 

 

	 	5.	All other provisions of the main Lease Agreement of January 6, 2005/ December 22, 2004, shall remain in force without change. 

 

							
	Essen,	 	  
	 		 	Mannheim, April 4, 2008
			
	 Alters- und Hinterbliebenen-Versicherung der
	 		 	Fa. Nitec Pharma GmbH
	 Technischen Überwachungs-Vereine WaG
	 		 	Joseph-Meyer-Str. 13-15
	 Kronprinzenstr. 30
	 		 	
			
	 45128 Essen
	 		 	68167 Mannheim
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Lessor)	 		 	(Lessee)

 Annex I: Ground plan of the sixth floor

 Annex II: Underground parking spaces and parking spaces on the first floor 
  

 Page 2 of the Addendum No. 3 AHV/Nitec 

 

 

 Annex I to the Addendum No. 3 

 7.1.5 
 Addendum No. 4 to the Lease Agreement of January 6, 2005 / December 22, 2004 
 Object: Janus-Office-Center, 
 Josef-Meyer-Str. 13-15, 68167 Mannheim

 between 
 Alters- und
Hinterbliebenen-Versicherung der 
 Technischen Überwachungs-Vereine VVaG 
 Kronprinzenstr. 30 
 45128 Essen 
 UST ID: DE 11 98 24807, 
 represented by the executive board, Dr. rer. pol. G. Wiedemann, and
Mr. Ralf Heynck 
 - hereinafter referred to as the “Lessor” - 
 and 
 the company 
 Nitec Pharma GmbH 
 Joseph-Meyer-Str. 13-15 

68167 Mannheim 
 represented by its managing
director, Dr. Achim Schäffler 
 - hereinafter referred to as the “Lessee” - 

 

	1.	Amendment to § 4 Term of Lease and Termination 

 The lease of the whole rented space shall be extended until December 31, 2010. 
  

	2.	Miscellaneous 

 All other
provisions of the main Lease Agreement of January 6, 2005/December 22, 2004, along with all addendums shall remain in force without change. 
  

					
	 Essen, September 24, 2008
	 		 	Mannheim, September 18, 2008
			
	Alters- und Hinterbliebenen-Versicherung der	 		 	Fa. Nitec Pharma GmbH
	Technischen Überwachungs-Vereine VVaG	 		 	Joseph-Meyer-Str. 13-15
	Kronprinzenstr. 30	 		 	
			
	45128 Essen	 		 	68167 Mannheim
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Lessor)	 	(Lessee)

  

 Page 1 of the Addendum No. 4 AHV/Nitec 

 Addendum No. 5 to the Lease Agreement of January 6, 2005 / December 22, 2004

 Object: Janus-Office-Center, 
 Josef-Meyer-Str. 13-15, D-68167 Mannheim 
 between 

Alters- und Hinterbliebenen-Versicherung der 

Technischen Überwachungs-Vereine VVaG 

Kronprinzenstr. 30 
 45128 Essen 

UST ID: DE 11 98 24807, 
 represented by the
executive board, Dr. rer. pol. G. Wiedemann, and Mr. Ralf Heynck 
 - hereinafter referred to as the “Lessor” - 

and 
 the company 

Nitec Pharma GmbH 
 Joseph-Meyer-Str. 13-15

 68167 Mannheim 
 represented by its
managing director, Dr. Achim Schäffler 
 - hereinafter referred to as the “Lessee” - 

 

	1.	Amendment to § 1 Rental Property 

 As of April 1, 2009, the Lessee shall in addition rent a store room on the first floor. 
  

	2.	Amendment to § 5 Rent 

Thus, as of April 1, 2009 the monthly rent payment shall amount to the following: 

 

									
	 Basic rent for the office space on the 2nd floor
	  	443.00 sqm	 	x	  	[...***...]	  	[...***...]
	 Basic rent for the office space on the 6th floor
	  	247.29 sqm	 	x	  	[...***...]	  	[...***...]
	 storage area on the 1st floor
	  	18.50 sqm	 	x	  	[...***...]	  	[...***...]
	 Underground parking spaces 125,126,127,128,132,133
	  		 		  		  	[...***...]
	 Parking spaces No. 32+33+10+11+2
	  		 		  		  	[...***...]
	 Basic rent total
	  		 		  		  	[...***...]
	 + Advance payment of service charges
	  	690.29 sqm	 	x	  	[...***...]	  	[...***...]
	 Net total: rent including heating
	  		 		  		  	€    7,487.85
	 + 19% VAT
	  		 		  		  	 €    1,422.69

***Confidential Treatment Requested 

									
	 Total amount
	  		  		  		  	€8,910.55
		  		  		  		  	 

  

	2.	Miscellaneous 

 All other
provisions of the main Lease Agreement of January 6, 2005 / December 22, 2004, together will all addendums, shall remain in force without change. 
  

					
	Essen, March 12, 2009	 		  	Mannheim, March 12, 2009
			
	Alters- und Hinterbliebenen-Versicherung der	 		  	Fa. Nitec Pharma GmbH
	Technischen Überwachungs-VereineVVaG	 		  	Joseph-Meyer-Str. 13-15
	Kronprinzenstr. 30	 		  	
			
	45128 Essen	 		  	68167 Mannheim
			
	 [Illegible Signature]
	 		  	 [Illegible Signature]

	(Lessor)	 		  	(Lessee)

  
 Page 2 of the Addendum No. 5
AHV/Nitec 

 Addendum No. 6 to the Lease Agreement of January 6, 2005 / December 22, 2004

 Object: Janus-Office-Center, 
 Josef-Meyer-Str. 13-15, 68167 Mannheim 
 between 

Alters- und Hinterbliebenen-Versicherung der 

Technischen Überwachungs-Vereine-WaG- 

Kurfürstenstr. 56, 45128 Essen 
 UST ID: DE
11 98 24807 
 represented by the executive board Mr. R. Heynck and Ms. S. Schwierz 
 - hereinafter referred to as “Lessor” - 
 and 

the company 
 Horizon Pharma GmbH 

in former times Nitec Pharma GmbH 

Joseph-Meyer-Str. 13-15, 68167 Mannheim 

represented by its managing director Dr. Achim Schäffler 
 - hereinafter referred to as “Lessee” - 
 Preamble 

The trade name of the company Nitec Pharma GmbH was changed to Horizon Pharma GmbH on June 22, 2010. Therefore, all rights and obligations resulting from
the existing lease agreement are simultaneously transferred to the company Horizon Pharma GmbH. 
  

	1.	Amendment to § 4 Term of Lease and Termination 

 The lease of the whole rented space shall be extended until December 31, 2011. 
  

	2.	Miscellaneous 

 All other
provisions of the main Lease Agreement of January 6, 2005 / December 22, 2004, along with all addendums shall remain in force without change. 
  

									
					
	Essen, the	 	26.8.2010	 		 	Mannheim, the	 	19. Aug. 2010
			
	 Alters-und Hinterbliebenen-Versicherung der
 Technischen Überwachungs-Vereine VVaG
 Kronprinzenstr.30
	 		 	 Fa. Horizon Pharma GmbH
 Joseph-Meyer-Str. 13-15

			
	45128 Essen	 		 	68167 Mannheim
			
	[signature]            [signature]	 		 	[signature]
	(Lessor)	 		 	(Lessee)
	[company’s stamp]	 		 	

 Page 1 of the Addendum No. 6 AHV/Horizon 

 7.1.4 
 Parking Space 
 Lease Agreement 

Joseph-Meyer-Str. 13-15, 68167 Mannheim 
 between 
 Alters- und Hinterbliebenen Versicherung der 

Technischen Überwachungsvereine VVaG 

Kurfürstenstr. 56 
 45138 Essen 

UST ID: DE 11 98 24807 
 represented by its
managing executive board member, Dr. rer. pol. G. Wiedemann, 
 and 
 the company 
 Nitec Pharma GmbH 
 Joseph-Meyer-Str. 13-15 
 68167 Mannheim 
 represented by its managing director, Mr Jochen Mattis, 
 -
hereinafter referred to as the “Lessee” - 
  

	1.	Leased Object 

 As of
August 1, 2007, the Tenant shall rent the following parking spaces in Joseph-Meyer-Str. 13-15, 68167 Mannheim: 
  

							
	 Parking spaces No. 10 +11
	  	x	  	[...***...]	  	[...***...]
	 + 16% VAT
	  		  		  	[...***...]
	 Overall rent for parking spaces per month
	  		  		  	[...***...]

  

	2.	Termination 

 The Lease
Agreement may be terminated by either party by giving one month’s notice. 
  

					
	Filderstadt, August 7, 2007	 		 	Mannheim, July 11, 2007
			
	[stamp: TÜV SÜD Immobilien Service GmbH]	 		 	[stamp: Nitec Pharma GmbH]
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Lessor)	 		 	(Lessee)

  

			
		 	***Confidential Treatment Requested

 ***Text Omitted and Filed Separately 

with the Securities and Exchange Commission. 
 Confidential Treatment Requested 
 Under 17 C.F.R. Sections 200.80(b)(4)

 and 230.406. 
 7.1.3 
 MIETVERTRAG 

über Gewerberäume 
 Zwischen 
 Alters- und Hinterbliebenen-Versorgungsstelle der 

Technischen Überwachungsvereine VVaG 

Kurfürstenstraße 58 
 45138 Essen

 -Vermieter 
 UST ID: DE 11 98 24807

 und 
 Firma 

Nitec Pharma GmbH 
 -Mieter- 

UST ID: 37009/52183 
 wird nachfolgender
Vertrag geschlossen: 

 MIETVERTRAG FÜR BÜRO- UND
VERWALTUNGSFLÄCHEN 
 INHALT und ANLAGEN 

 

					
	 Seite
	  	 Inhalt

	1	  	Inhaltsverzeichnis
			
	3	  	§ 1	  	 Mietsache

	3	  	§ 2	  	 Benutzung der Mietsache

			
	4	  	§ 3	  	 Ausstattung der Mieträume

	4	  	§ 4	  	 Mietzeit, Kündigung

			
	5	  	§ 5	  	 Mietzins

			
	6	  	§ 6	  	 Umsatzsteuer

	6	  	§ 7	  	 Änderung des Mietzinses

			
	7	  	§ 8	  	 Zahlung des Mietzinses

	7	  	§ 9	  	 Übergabe und Zustand der Mietsache

	7	  	§ 10	  	 Gebrauchsüberlassung an Dritte

			
	8	  	§ 11	  	 Instandhaltung und Instandsetzung

	8	  	§ 12	  	 Versicherungen

			
	9	  	§ 13	  	 Beschilderung / Reklameanlagen

	9	  	§ 14	  	 Objektbewachung und Sicherheitseinrichtungen

			
	10	  	§ 15	  	 Mängel der Mietsache / Gegenansprüche

	10	  	§ 16	  	 Veränderungen der Mietsache durch den Mieter

	10	  	§ 17	  	 Veränderungen der Mietsache durch den Vermieter

			
	11	  	§ 18	  	 Betreten der Mietsache

	11	  	§ 19	  	 Vermieterpfandrecht/Sicherheitsleistung

			
	12	  	§ 20	  	 Beendigung des Mietverhältnisses

			
	13	  	§ 21	  	 Sonstige Vereinbarungen

			
	Anlage I	  		  	 Aufstellung der Betriebs- und Nebenkosten

	Anlage II	  		  	 Grundrisszeichnungen der Mietflächen

 § 1 - Mietsache 
  

	1.1	Der Vermieter ist Eigentümer der Liegenschaft Joseph-Meyer-Straße 13-15, 68167 Mannheim. 

 

	1.2	 Der Vermieter vermietet an den Mieter Büroflächen in dem vorstehend beschriebenen Gebäude im 1. Obergeschoss mit insgesamt 171,18
m2, darin enthalten sind Haupt-und Nebennutzflächen
und die damit verbundenen Verkehrs- und Funktionsflächen. 

 Der beigefügte Lageplan ist Bestandteil
des Mietvertrages (Anlage II). 
  

	1.3	Solltgen sich bei nachträglicher Vermessung der Mietflächen eine Abweichung von der angegebenen Mietfläche ergeben, ist keine der Parteien berechtigt,
von diesem Vertrag zurückzutreten, ihn zu kündigen oder eine Änderung des Mietzinses zu verlangen. Die angegebenen Flächen sind zugrunde zu legen, soweit es nach den Bestimmungen dieses Vertrages auf die Größe der
vermieteten Flächen ankommt. 

  

	1.4	Die Vermietung erfolgt zur Nutzung als Bürobetrieb. 

 Eine Änderung dieses Nutzungszweckes ist nur mit schriftlicher Genehmigung des Vermieters zulässig. Etwaige Genehmigungserklärungen des Vermieters werden stets, auch wenn dies nicht
nochmals ausdrücklich gesagt ist, vorbehaltlich einer etwa erforderlichen behördlichen Genehmigung zur Nutzungsänderung erteilt, deren Beschaffung dem Mieter auf eigene Kosten obliegt und die dem Vermieter nachzuweisen ist.

 § 2 - Benutzung der Mietsache 
  

	2.1	Die Mietsache wird zu dem in Ziff. 1.4 genannten Nutzungszweck durch den Mieter gemietet. 

 

	2.2	Der Vermieter übernimmt keine Gewähr dafür, dass der vorgesehene Betrieb des Mieters in der Mietsache öffentlich-rechtlich zulässig ist. Der
Mieter hat auf seine Kosten sämtliche Voraussetzungen für seinen Betrieb zu schaffen und während der Mietzeit aufrechtzuerhalten. Auflagen der Gewerbeaufsicht oder anderer Stellen hat der Mieter auf eigene Kosten zu erfüllen,
auch soweit es sich urn Raumbezogene Auflagen handelt. 

 Die GüItigkeit dieses Mietvertrages ist
unabhängig von einer etwa erforderlichen behördlichen Zulassung der gewerblichen Tätigkeit des Mieters. 
  

	2.3	Der Mieter verpflichtet sich, für die Dauer dieses Vertrages seinen vorgesehenen Betrieb in den Mieträumen aktiv zu betreiben und entsprechend seiner
Betriebsart geöffnet bzw. besetzt zu halten (Betriebspflicht). 

  

	2.4	Der Vermieter räumt dem Mieter keinerlei Konkurrenzschutz ein. 

  
 Seite 34 des Mietvertrages
vom 21.12.2004 

	2.5	Vor der Aufstellung von Maschinen, schweren Gegenständen, anderen Anlagen und Einrichtungen in den Mieträumen hat sich der Mieter über die zulässige
Bela-stungsgrenze der Stockwerksdecken beim Vermieter zu erkundigen und seine schriftliche Zustimmung einzuholen. Für Schäden, die durch Nichtbeachtung dieser Bestimmungen eintreten, haftet der Mieter. Führen solche Anlagen und
Einrichtungen des Mieters zu nachteiligen Auswirkungen auf das Gebäude (Erschütterungen, Risse usw.) oder zu Nachteilen oder Unzuträglichkeiten (z. B. Lärm, Staub, störende Gerüche etc.) der Mitbenutzer im Gebäude,
so kann der Vermieter die Zustimmung widerrufen und vom Mieter Unterlassung verlangen. 

  

	2.6	Zur Anmietung gehört auch das Recht des freien Zugangs und der freien Zufahrt zur Mietsache. 

§ 3 - Ausstattung und Übergabe der Mieträume durch den Vermieter 

 

	3.1	Der Zustand und die Ausstattung der Mietsache, wie sie steht und liegt, ist dem Mieter bekannt. 

 

	3.2	Die Mietsache wird dem Mieter spätestens Januar 2005 übergeben. Von der Übergabe ist ein Protokoll zu erstelien. 

§ 4 - Mietzeit und Kündigung 
  

	4.1	Das Mietverhältnis beginnt am 01. Januar 2005 und wird auf die Dauer von 1,5 Jahren bis zum 30.06.2006 abgeschlossen. Bei Beendigung des Mietverhältnisses
findet § 568 BGB für die Vertragsparteien keine Anwendung. 

  

	4.2	Während der Dauer des Mietverhältnisses ist die ordentliche Kündigung ausge-schlossen. Das Recht zur außerordentlichen fristlosen Kündigung
aus wichtigem Grund beider Parteien bleibt unberührt. Ein wichtiger außerordentlicher Kündigungsgrund für den Vermieter liegt insbesondere vor, wenn 

 

	 	a)	der Mieter mit mehr als einer Monatsmiete in Rückstand gerät oder die vereinbarte Sicherheitsleistung nicht in der nach diesem Vertrag vorgesehenen Zeit,
Höhe und Art gestellt hat; 

  

	 	b)	der Mieter ohne Zustimmung des Vermieters die Mietsache oder Teile davon baulich verändert oder zu anderen als im Vertrag bestimmten Zwecken benutzt, insbesondere
Dritten zum Gebrauch überlässt bzw, untervermietet; 

  

	 	c)	der Mieter seine Zahlungen einstellt, es zur Einleitung eines gerichtlichen oder außergerichtlichen Vergleichs—oder Konkursverfahrens über sein
Vermögen—kommen lässt oder die eidesstattliche Versicherung über sein Vermögen ableisten muß; 

  
 Seite 35 des Mietvertrages
vom 21.12.2004 

	 	d)	der Mieter in derselben Sache trotz zweimaliger schriftlicher Abmahnung die Vertragsbedingungen nicht einhält. 

 

	4.3	Dem Mieter wird die Option eingeräumt, das Vertragsverhältnis nach Ablauf der unter Punkt 4.1 geregelten Mietvertragslaufzeit um ein, zwei oder drei Jahre zu
verlängem. Nimmt der Mieter von seinem Optionsrecht Gebrauch, so hat er dies in schriftlicher Form dem Vermieter 6 Monate vor jeweiligem Ablauf des Mietverhältnisses mitzuteilen. Die Kündigung hat 6 Monate vor dem jeweiligen Ablauf zu
erfolgen. 

  

	4.5	Soweit der Mieter eine natürliche Person ist, wird das vorzeitige Kündigungsrecht gemäß § 569 BGB hiermit ausgeschlossen.

 § 5 Mietzins 
  

	5.1	Der Mietzins setzt sich für die Grundmietzeit vom 01.01.05 – 30.06.05 monatlich wie folgt zusammen: 

 

									
	 Bürofläche
	  	171,18 m2	  	x	  	[...***...]	  	[...***...]
	 3 Tiefgaragensteliplätze
	  		  		  		  	[...***...]
	 Nebenkostenvorauszahlung
	  	171,18 m2	  	x	  	[...***...]	  	[...***...]
					
	 Zwischensumme netto
	  		  		  		  	[...***...]
	 Mehrwertsteuer 16 %
	  		  		  		  	[...***...]
					
	 Summe brutto gesamt
	  		  		  		  	[...***...]

 Sollte der Mieter die in § 4 vereinbarte Option über 1 Jahr ausüben, bleibt der Mietzins in Höhe von [...***...] bestehen, bei 2 jähriger Dauer reduziert sich der Mietzins
pro m2 auf [...***...,] bei 3 jähriger Dauer
auf [...***...] pro m2. 

 

	5.2	Zusätzlich zur Grundmiete übernimmt der Mieter alle für die Mietsache bei ihm direkt anfallenden Betriebskosten (z. B. Strom, Gas, Wasser, Telefon- und
andere Kommunikationskosten) sowie sämtliche Betriebs- und Nebenkosten des Hauses. Betriebs- und Nebenkosten sind alle in der Anlage I zu diesem Vertrag aufgeführten Kosten sowie alle etwaigen künftig entstehenden Kosten, die
durch Gesetz, Verordnung, Ortssatzung oder auf sonstiger Grundlage künftig neu für das Mietobjekt eingeführt werden. Bei der Aufstellung der Betriebs- und Nebenkosten gemäß Anlage I handelt es sich daher um eine
beispielhafte und nicht um eine abschließende Aufzählung möglicher anfallender Kosten. 

  

	5.3	Diese Betriebs- und Nebenkosten werden vom Vermieter auf den Mieter umgelegt und mit ihm abgerechnet. Bei mehreren Mietem im Gebäude bestimmt der Vermieter den
Umlagemaßstab (Verteilungsschlüssel) nach seinem Ermessen, soweit zwingende gesetzliche Bestimmungen dies vorschreiben, gemäß diesen Bestimmungen. Grundsätzlich richtet sich der Verteilungsschlüssel nach dem Anteil
der vermietbaren Fläche an der Gesamtfläche. 

  
  

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	5.4	Die Abrechnung erfolgt jährlich durch den Vermieter spätestens bis zum 15.12. des Folgejahres. Endet das Mietverhäitnis während einer
Abrechnungsperiode, wird die Abrechnung im Rahmen der nächstfolgenden Jahresabrechnung vorgenommen. 

  

	5.5	Erhöhen sich die Betriebskosten oder sind Erhöhungen sicher zu erwarten (z. B. durch Ankündigung kommunaler Gebührenerhöhungen), so ist der
Vermieter berechtigt, eine entsprechende Erhöhung der Vorauszahlungen zu verlangen. 

 § 6 Umsatzsteuer

  

	6.1	Zuzüglich zur vereinbarten Grundmiete einschließlich der Betriebs- und Nebenkosten hat der Vermieter die Umsatzsteuer in ihrer jeweiligen gesetzlichen
Höhe zu entrichten. Der Mieter versichert, dass er die Mieträume ausschließlich für Umsätze verwendet oder zu verwenden beabsichtigt, welche den Vorsteuerabzug beim Vermieter nicht ausschließen. Sollte der Mieter
entgegen dieser Zusicherung die Mieträume nicht ausschließlich für solche Umsätze verwenden, die den Vorsteuerabzug nicht ausschließen (steuerschädliche Verwendung), so erhöht sich die Grundmiete
einschließlich Nebenkosten im Zeitraum der umsatzsteuerschädlichen Verwendung um denjenigen Betrag, welcher der jeweiligen auf die Grundmiete zuzüglich Betriebs- und Nebenkosten zu entrichtenden Umsatzsteuer entspricht.

  

	6.2	Auf Verlangen des Vermieters ist der Mieter verpflichtet, die ausschließliche Verwendung der Mietsache für Umsätze, die den Vorsteuerabzug nicht
ausschließen, nachzuweisen. Der Mieter hat den bevorstehenden Beginn einer solchen steuerschädlichen Verwendung dem Vermieter unverzüglich anzuzeigen und ihm jeglichen Schaden zu ersetzen, der diesem aus einer Verletzung der
Anzeigepflicht erwächst; hierzu zählt insbesondere jeder Schaden beim Vermieter daraus, dass dieser nach Beginn der steuerschädlichen Verwendung Umsatzsteuern an das Finanzamt abführt, obwohl nunmehr eine umsatzsteuerfreie
Vermietung vorliegt. Schadensersatzansprüche dieser Art verjähren nicht vor Ablauf von 6 Monaten nach bestandskräftiger Feststellung durch eine Finanzbehörde oder ein Finanzgericht, dass der Vermieter nicht oder nicht mehr zum
Vorsteuerabzug berechtigt ist. 

 § 7 - Änderung des Mietzinses 

 

	7.1	 Ändert sich der vom Statistischen Bundesamt festgesteilte Preisindex für die Lebenshaltung aller privaten Haushalte (Verbraucherpreisindex
für Deutschland) (Basisjahr 2000 = 100 Punkte) gegenüber dem Stand 30.06.2009 oder gegenüber der letzten Mietanpassung um mehr als [...***...], so ändert sich jeweils die in § 5 vereinbarte Grundmiete prozentual entsprechend. Die
Änderung wird von dem Monatsersten an wirksam, der auf die Veränderung folgt. 

  
  

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	7.2.	Sollte diese Wertsicherungsklausel nicht gem. § 4 der Preisklauselverordnung als genehmigt gelten, so verpflichten sich die Parteien eine dem wirtschaftlichen Sinn
und Zweck am ehesten entsprechende Wertsicherungsklausel zu vereinbaren, die nach den dann geltenden Vorschriften genehmigungsfähig ist. 

 § 8 - Zahlung des Mietzinses 
 Die Mietzinszahlung beginnt am
01.01.2005. 
 Der Mietzins ist spätestens bis zum 3. Werktag eines jeden Monats auf das Konto der [...***...]

 § 9 - Übergabe der Mietsache / Zustand der Mietsache 

 

	9.1	Die Übergabe der Mietsache ist vorgesehen für den Zeitpunkt des Mietbeginns gemäß § 4.1. Den verbindlichen Übergabetermin teilt der
Vermieter dem Mieter schriftlich so früh wie möglich mit. 

 Ausstehende Restarbeiten, wie z. B. die
völlige Herstellung der Außenanlagen und/oder die Mängelbeseitigung, hindem die Übernahme der Mietsache nicht. 
  

	9.2	Anlässlich der Übergabe wird von den Parteien ein Übergabeprotokoll gefertigt, das den Zustand der Mietsache und etwaige Mängel zu diesem Zeitpunkt
dokumentiert. 

 Übergabeprotokoll festgestellte Mängel hat der Vermieter innerhalb einer angemessenen
Nachfrist zu beseitigen. 
 § 10 - Gebrauchsüberlassung an Dritte 

 

	10.1	Jede ganze oder teilweise Gebrauchsüberlassung an Dritte, insbesondere die Untervermietung der Mietsache, bedarf vor Abschluss der Zustimmung des Vermieters. Ein
Kündigungsrecht des Mieters wegen Verweigerung dieser Zustimmung ist ausgeschlossen. Sind für eine anderweitige Nutzung, welche der Vermieter genehmigt hat, im Rahmen einer solchen Gebrauchsüberlassung Behördenauflagen zu
erfüllen, gehen auch diese ausschließlich zu Lasten des Mieters. 

  

	10.2	Der Vermieter kann die Zustimmung zur Untervermietung aus wichtigem Grund widerrufen. Dies darf jedoch nicht zur Unzeit geschehen. 

  
  

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 § 11 – Instandhaltung/Instandsetzung/Schönheitsreparaturen/Haftung für Schäden

  

	11.1	Dem Mieter obliegen die Schönheitsreparaturen sowie die sonstigen Instandhaltungs- und Instandsetzungsarbeiten innerhalb der Mieträume, soweit die
Schäden durch den Gebrauch des Mieters entstanden sind (Abnutzung, Verschleiß, Beschädigung durch den Mieter oder seine ErfüIlungsgehilfen). 

 § 12 - Versicherungen 
  

	12.1	Die übliche Gebäudeversicherung (Feuer, Sturm, Leitungswasser, Extended Coverage) und die Gebäudehaftpflichtversicherung werden vom Vermieter zu Lasten
der Betriebs- und Nebenkosten abgeschlossen. Durch den Mieter vorgenommene Ein-, Aus- oder Umbauten des Mietobjektes sind nicht von der Gebäudeversicherung gedeckt. Der Mieter ist verpflichtet, diese Ein-, Aus- oder Umbauten auf eigene Kosten
selbst zu versichem. 

  

	12.2	Der Mieter ist verpflichtet, eine ausreichende Betriebshaftpflicht- sowie eine Einbruchdiebstahlversicherung und eine ausreichende Versicherung der eingebrachten
Einrichtungen und Sachen gegen alle Beschädigungen auf eigene Kosten abzuschließen und für die Dauer der Mietzeit aufrechtzuerhalten. 

  

	12.3	Der Vermieter hat das Recht, sich von dem ordnungsgemäßen Abschluss der gem. § 12.2 vom Mieter abzuschließenden Versicherungen und deren
Aufrechterhaltung durch Einsichtnahme in die Versicherungsverträge zu überzeugen. Dies gilt ebenso über die Zahlung der Erstprämie der jeweiligen Versicherung. 

§ 13 - Beschilderung Reklameanlagen 
  

	13.1	Dem Mieter ist das Anbringen von Namens- und Firmenschildem im Eingangsbereich und im Bereich der Eingangstüren zu ihren Mieträumen an den vom Vermieter
hierfür vorgesehenen Stellen gestattet. Sonstige Gebäudeteile oder Flächen des Anwesens sind nicht mitvermietet; Reklameanlagen, Warenautomaten, Schaukästen, Verkaufsstände, Schilder, Markisen, Antennen u. ä.
dürfen daher dort nicht angebracht oder aufgestellt werden. 

  

	13.2	Darüber hinausgehende Reklameanlagen oder andere Einrichtungen gemäß § 13.1, welche der Mieter anbringen oder aufstellen will, bedürfen der
vorherigen, schriftlichen Genehmigung des Vermieters, die auch mit Auflagen und Kostentragungspflichten verbunden werden kann. 

  

	13.3	Der Vermieter behält sich vor, die Beschilderung oder das Anbringen von Reklameanlagen und sonstigen Vorrichtungen einheitlich nach einem gemeinschaftlichen
Werbekonzept für das Anwesen zu gestalten. Diesem einheitlichen Konzept hat sich der Mieter mit seiner Beschilderung und seinen Reklameanlagen und sonstigen Vorrichtungen anzupassen. Die Kosten der Beschilderung trägt der Mieter.

  
 Seite 39 des Mietvertrages
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 § 14 - Objektbewachung und Sicherheitseinrichtungen 

 

	14.1	Falls die Parteien für das Objekt Bewachungsmaßnahmen als notwendig betrachten, sind diese vom Mieter zu dulden, soweit sie ihm rechtzeitig angezeigt werden.
Der Mieter verpflichtet sich, die hierfür anfallenden Kosten zu tragen, bei mehreren Mietem anteilig nach dem Umlagemaßstab für andere Betriebs- und Nebenkosten. 

 

	14.2	Dies gilt entsprechend für den Fall der Installation von Sicherheitseinrichtungen durch den Vermieter. Die Installation von Sicherheitseinrichtungen innerhalb der
Mieträume durch den Mieter bedarf der vorherigen Zustimmung des Vermieters. 

 §15 Mängel der
Mietsache/Gegenansprüche 
 Es gelten die gesetzlichen Regelungen 

§ 16 - Veränderungen der Mietsache durch den Mieter 
  

	16.1	Veränderungen an und in der Mietsache, insbesondere Um- und Einbauten, Installationen und dergleichen dürfen nur mit schriftlicher Einwilligung des Vermieters
vorgenommen werden. 

  

	16.2	Gas-, Elektro- und sonstige Geräte dürfen nur in dem Umfang an das vorhandene Leitungsnetz angeschlossen werden, als die für die Mietsache vorgesehene
Belastung nicht überschritten wird. 

 § 17 - Veränderungen der Mietsache durch den Vermieter 

 

	17.1	Der Vermieter darf Ausbesserungen und bauliche Veränderungen, die zur Erhaltung oder zur Abwendung drohender Gefahren oder zur Beseitigung von Schäden oder
zur Verbesserung der Mietsache und ihrer Vermietung notwendig oder zweckmäßig werden, auch ohne Zustimmung des Mieters vornehmen. Der Mieter hat die in Betracht kommenden Räume zugänglich zu halten und darf die Ausführungen
der Arbeiten nicht hindern oder verzögem; andernfalls hat er den dadurch entstehenden Schaden zu ersetzen. 

  

	17.2	Auf die betrieblichen Belange des Mieters ist angemessene Rücksicht zu nehmen. Insbesondere hat der Vermieter die Durchführung solcher Arbeiten rechtzeitig
anzukündigen. Die Ankündigungspflicht gilt nicht bei Gefahr im Verzug. 

  
 Seite 9 des Mietvertrages vom
21.12.2004 

 § 18 - Betreten der Mietsache 

Der Mieter hat während der üblichen Geschäftszelt zu gewährleisten, dass der Vermieter oder seine Beauftragten,
Sachverständige und Interessenten die Mietsache zum Zwecke der Neuvermietung, des Verkaufes, zur Feststellung des Zustandes oder zur Vornahme von Arbeiten jederzeit - nach Voranmeldung - betreten und besichtigen können. 

In Fällen von Gefahr im Verzug ist das Betreten der Mietsache zu jeder Tages- und Nachtzeit durch den Mieter zu ermöglichen.

 § 19 - Pfandrecht des Vermieters / Sicherheitsleistung 

 

	19.1	Der Vermieter hat für alle auch künftigen Forderungen aus diesem Vertrag ein Pfandrecht an den eingebrachten Sachen des Mieters (Büromöbel,
Maschinen und sonstige Gegenstände der Geschäftsausstattung und Einrichtung). 

  

	19.2	Bei Pfändung eingebrachter Sachen durch Dritte verpflichtet sich der Mieter, den Vermieter unverzüglich unter Vorlage der Unterlagen von den Einzelheiten und
dem Umfang der Pfändung zu benachrichtigen. 

  

	19.3	Der Mieter leistet zur Absicherung aller Ansprüche des Vermieters aus diesem Mietvertrag und seiner Beendigung spätestens 14 Tage vor Mietbeginn
gemäß § 4.1 eine Sicherheitsleistung (Bürgschaft) in Höhe von [...***...] zuzüglich vereinbarter oder geschätzter Betriebs- und Nebenkosten und zuzüglich der jeweiligen gesetzlichen
Mehrwertsteuer, in Höhe von 

 [...***...] 

[...***...] 
 Diese Sicherheitsleistung ist in Form einer unbedingten, unwiderruflichen, unbefristeten und selbstschuldnerlschen Bürgschaft einer in der Bundesrepublik Deutschland ansässigen Großbank zu
erbringen, bei welcher die bürgende Bank auf das Recht zur Anfechtung, zur Aufrechnung, zur Hinterlegung und die Rechte und Einreden aus §§ 768, 776 BGB verzichtet und sich zur Zahlung auf erstes Anfordern durch den Vermieter
verpflichtet hat. 
 Die Bürgschaft darf über die Bestimmung hinaus, dass die Bürgschaftsverpflichtung mit
Rückgabe der Bürgschaftsurkunde durch den Vermieter an die Bürgen oder dann, wenn nach Beendigung des Mietverhältnisses sämtliche Verpflichtungen des Mieters aus dem Mietverhältnis erfüllt sind, zurückzugeben
ist, gegebenenfalls um vom Vermieter in Anspruch genommene Beträge gemindert, keine weiteren Bedingungen und Einschränkungen enthalten. 

  
  

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	19.4	Kommt es während der Mietzeit zu einer Veränderung der Grundmiete und/oder der Betriebs- und Nebenkosten um mindestens [...***...] des bisherigen
monatlichen Gesamtbetrages, so ist der Mieter auf Verlangen des Vermieters zu einer entsprechenden Anpassung seiner Sicherheitsleistung binnen 14 Tagen ab Aufforderung verpflichtet. 

§ 20 - Beendigung des Mietverhältnisses 
  

	20.1	Bei Beendigung des Mietverhältnisses hat der Mieter die Mietsache gereinigt in ordnungsgemäßem Zustand mit sämtlichen Schlüsseln an den
Vermieter herauszugeben. Spätestens bis zum Zeitpunkt des Mietendes hat der Mieter ferner in jedem Fall notwendige, die ihm nach § 11 obliegenden Schönheitsreparaturen, Instandhaltungs- und Instandsetzungsmaßnahmen
vollständig durchzuführen; andernfalls kann der Vermieter auf Kosten des Mieters ohne nochmalige Mahnung und Fristsetzung solche Reparaturen und Maßnahmen anstelle des Mieters auf dessen Kosten selbst durchführen.

  

	20.2	Einrichtungen, mit welchen der Mieter die Mietsache versehen hat und alle von ihm etwa während der Mietzeit vorgenommenen Änderungen der Mietsache,
insbesondere Ein- und Umbauten, einschließlich Beschilderungen, Reklameanlagen und sonstiger Vorrichtungen gemäß § 13 dieses Vertrages, hat der Mieter auf seine Kosten vor Auszug fachgerecht zu entfemen und den
ursprünglichen Zustand der Mietsache wieder herzustellen. 

 Die bei Mietbeginn in den Mieträumen
befindlichen Verkabelungen, der eingebaute Serverraum und die im Serverraum befindliche Klimaanlage ist nach dem Auszug des Mieters nicht zurückzubauen. 
 Der Vermieter kann die Ausübung dieses Wegnahmerechts durch Zahlung einer angemessenen Entschädigung abwenden, die sich nach dem Zeitwert der Einrichtung bestimmt. 

  
 Seite 11 des Mietvertrages
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 § 21 - Sonstige Vereinbarungen 

 

	21.1	Erfüllungsort und Gerichtsstand für alle sich aus diesem Vertrag ergebenden Verpflichtungen ist Mannheim. 

 

	21.2	Durch die Ungültigkeit einer oder mehrerer Bestimmungen dieses Vertrages wird die Gültigkeit der übrigen nicht betührt Für den Fall der
Nichtigkeit einzelner Bestimmungen sind die Parteien verpflichtet, an ihrer SteIle eine solche Regelung zu treffen, die der ursprünglichen vorgestellten mit rückwirkender Kraft am nächsten kommt. 

 

	21.3	Nebenabreden, Änderungen, Ergänzungen und Aufhebung des Vertrages sind nur wirksam, wenn sie schriftlich vereinbart werden. Das gleiche gilt für Zusagen
und Zustimmungen aller Art. Auf die Schriftform kann nur schriftlich und ausdrücklich verzichtet werden. Insbesondere bedürfen der Schriftform alle im Rahmen dieses Vertrages anfallenden Erklärungen, wie Kündigungen,
Zustimmungen, Genehmigungen und dergleichen. 

  

	21.4	Der in den Büroräumen eingebaute Serverraum, inklusive der technischen Einrichtungen (z.B. zusätzliche Verkabelung, Klimaanlage) sowie die
zusätzliche Türschließanlage incl. der Installationen verbleibt beim Auszug des Mieters in den Räumlichkeiten. 

  

	21.5	Auf die zu diesem Vertrag gehörenden AnIagen I - II wird Bezug genommen. 

 

					
	Essen, den 06.01.2005	 		 	Munich, den 22.12.04
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Vermieter)	 		 	(Mieter)

  
 Seite 12 des Mietvertrages
vom 21.12.2004 

 Anlage I zum Mietvertrag AHV / Fa. Nitec Pharma 
 AUFSTELLUNG DER BETRIEBS- UND NEBENKOSTEN 
 Betriebskosten und Nebenkosten sind nachstehende
Kosten, die dem Eigentümer durch das Eigentum am Grundstück oder durch den Bestimmungsmäßigen Gebrauch des Gebäudes oder der Wirtschaftseinheit, der Nebengebäude, Anlagen, Einrichtungen und des Grundstückes
laufend entstehen, es sei denn, dass sie üblicherweise vom Mieter außerhalb der Miete unmittelbar getragen werden: 
  

	1.	Die laufenden öffentlichen Lasten des Grundstücks 

 Hierzu gehört namentlich die Grundsteuer. 
  

	2.	Die Kosten der Wasserversorgung 

 Hierzu gehören die Kosten des Wasserverbrauchs, die Grundgebühren und die Zählermiete, die Kosten der Verwendung von Zwischenzählern und die Kosten des Betriebs. 

 

	3.	Die Kosten der Entwässerung 

 Hierzu gehören die Gebühren für die Benutzung einer öffentlichen Entwässerungs-anlage, inklusiv der Einleitung von Regenwasser und die Kosten des Betriebs. 

 

	4.	Die Kosten der Heizungsanlage 

 Hierzu gehören die Kosten des Betriebs und der Reinigung 
  

	 	a)	der Heizungsanlage sowie die Kosten der Verwendung einer messtechnischen Ausstattung zur Verbrauchserfassung. Heizungsanlagen können z.B. zentrale Heizungsanlage
oder mit der Warmwasserversorgungsanlage verbundene Heizungsanlagen, zentrale Brennstoffversorgungsanlagen oder Etagenheizungen sein; 

  

	 	b)	die Kosten der Versorgung mit Fernwärme und die Kosten des Betriebes 

  

	 	c)	die Kosten der Ablesung und Auswertung der Geräte zur Verbrauchserfassung. 

  
 Seite 13 des Mietvertrages
vom 21.12.2004 

	5.	Die Kosten der Warmwasserversorgung 

 Hierzu gehören die Kosten des Betriebs und der Reinigung 
  

	 	a)	der Warmwasserversorgungsanlagen, wie z. B. zentrale oder mit der Heizungs-anlage verbundene Warmwasserversorgungsanlagen; 

 

	 	b)	die Kosten der Versorgung mit Femwarmwasser und die Kosten des Betriebs der zugehörigen Hausanlagen; 

 

	 	c)	der Warmwassergeräte und Geräte zur Verbrauchserfassung; 

  

	 	d)	die Kosten der Ablesung und Auswertung der Geräte zur Verbrauchserfassung. 

 

	6.	Die Kosten der Klima-, Be- und Entlüftungsanlagen 

 Hierzu gehören die Kosten des Betriebs 
  

	7.	Die Kosten des maschinellen Personen- oder Lastenaufzuges 

 Hierzu gehören die Kosten des Betriebsstroms, die Kosten der Beaufsichtigung, der Bedienung, Überwachung und Pflege der Anlage, der regelmäßigen Prüfung ihrer
Betriebsbereitschaft und Betriebssicherheit einschl. der Einstellung durch einen Fachmann und die Kosten der Reinigung. 
  

	8.	Die Kosten der Straßenreinigung und MüIlabfuhr 

 Hierzu gehören die für die öffentliche Straßenreinigung und Müllabfuhr zu entrichtenden Gebühren und die Kosten entsprechender nicht öffentlicher Maßnahmen.

  

	9.	Die Kosten der Reinigung und Ungezieferbekämpfung 

 Zu den Kosten der Reinigung gehören u. a. die Kosten für die Säuberung des Objektes, u. a. der Zugänge, Eingangsbereiche, Flure, Treppenhäuser, Keller, Bodenräume,
Waschküchen, Technikräumen, Aufzugsfahrkörbe sowie Fassaden bzw. die Glasreinigung. 
  

	10.	Die Kosten der Außenanlagen 

 Hierzu gehören die Kosten der Pflege gartnerisch angelegtër Flächen einschl. der Erneuerung von. Pflanzen und Gehölzen, der Pflege von Spielplätzen einschl. der Erneuerung von
Sand. Des Weiteren die Pflege, Reinigung, Räumung und Streuung von Plätzen, Zugängen und Zufahrten, die dem nicht öffentlichen Verkehr dienen. 

  
 Seite 14 des Mietvertrages
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	11.	Die Kosten der Beleuchtung 

Hierzu gehören die Kosten des Stroms für die Außenbeleuchtung und die Beleuchtung der allgemeinen Gebäudetelle des
Objektes, wie z.B. Zugänge, Eingangsbereiche, Flure, Treppenhäuser, Keller, Bodenräume, Waschküchen und Technikräume. 
  

	12.	Die Kosten der Schornsteinreinigung 

 Hierzu gehören die Kehrgebühren nach der maßgebenden Gebührenordnung. 
  

	13.	Die Kosten der Versicherungen 

 Hierzu gehören die Kosten aller Versicherungen, die für das Objekt abgeschlossen werden, wie Gebäudeversicherung mit “all-risk”-Deckung, Glasversicherung, Haft-pflichtversicherung
für das Gebäude, den Oltank, den Aufzug, sowie Mietverlustver-sicherung. 
  

	14.	Die Kosten für den Hauswart, des Portiers bzw. Pförtners und des sonstigen für den Betrieb des Gebäubes benötigten Personals

 Hierzu gehören u.a. die Personalnebenkosten sowie Sondervergütungen. 

 

	15.	Die Kosten für Beschilderung und Werbeanlagen 

 Hierzu gehören die Kosten für die Anbringung und den Betrieb von Beschilderungs- und Reklameanlagen. Zu Beschilderungsanlagen gehören z. B. Firmen-, Namens-, Lage- und
Informationsbeschilderungen. 
  

	16.	Die Kosten des Objektmanagements 

 Hierzu gehören die Kosten des Objektmanagements mit technischer und kaufmännischer Betreuung. 
  

	17.	Die Kosten der Blilzschutzanlage 

  

	18.	Die Kosten der Garagen 

Hierzu gehören die Kosten des Betriebs und die Reinigung und Wartung der Garagenanlagen. 

 

	19.	Die Kosten des Betriebsstroms 

 Hierzu gehören die Kosten des Betriebsstroms für die gemeinschaftlichen Gebäudeteile und -anlagen, soweit sie nicht von den Nutzem selbst getragen werden oder in den vorgenannten Punkten
beinhaltet sind. 
  

	20.	Die Kosten für Wartungen 

 Hierzu gehören die Kosten für alle Wartungsarbeiten, die im Objekt durchgeführt werden und nicht in den vorgenannten Punkten beinhaltet sind. 

  
 Seite 15 des Mietvertrages
vom 21.12.2004 

	21.	Sonstige öffentliche Gebühren 

  

	22.	Die Kosten 

 des Betriebs

  

	 	a)	der Gemeinschafts-Antennenanlage bzw. 

  

	 	b)	der mit einem Breitbandkabelnetz verbundenen privaten Verteileranlage bzw. 

 

	 	c)	der Satellitenempfangsanlage 

  

	23.	Die Kosten für die Objektbewachung und Sicherheitseinrichtungen 

 Hierunter gehören die Kosten für regelmäßige und besondere Be- und Überwachungsmaßnahmen sowie die Kosten für Fertigung, Anbringung und Betrieb für
Sicherheitseinrichtungen. 
  

	24.	Die Kosten sonstiger Geräte 

 Hierzu gehören die Kosten des Betriebs z. B. maschineller Wasch- und Trockeneinrichtungen. 
  

	25.	Die Kosten der Mietnebenkostenkonten 

 Hierzu gehören die Kapitalkosten der Mietnebenkostenkonten, wie z. B. Bearbeitungsgebühren, Kontogebühren, Sollzinsen. 

 

	26.	Sonstige Betriebskosten 

Das sind die in den Nummern 1 bis 25 nicht genannten Betriebskosten, namentlich die Betriebskosten von Nebengebäuden, Anlagen und
Einrichtungen. 
  

					
	Essen, den 06.01.2005	 		 	Mannheim, den 22.12.04
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Vermieter)	 		 	(Mieter)
	 Alters- und Hinterbliebenen-Versorgungsstelleder

Technischen Überwachungs-Vereine (VVaG)
	 		 	
	Kurfürstenstraße 56 - 45138 Essen	 		 	

  
 Seite 16 des Mietvertrages
vom 21.12.2004 

 

 

  

 Nachtrag Nr. 1 zum Mietvertrag vom 06.01.2005 / 22.12.2004 

Objekt: Janus-Office-Center,
 Josef-Meyer-Str. 13-15, 68167 Mannheim 
 zwischen 

Alters- und Hinterbliebenen Versicherung der 

Technischen Überwachungsvereine VVaG 

Kurfürstenstr. 56 
 45138 Essen 

UST ID: DE 11 98 24807 
 Vertreten durch den
Geschf. Vorstand Herr Dr. rer. Pol. G. Wiedemann 
 und 
 Firma 
 Nitec Pharma GmbH 
 Joseph-Meyer-Str. 13-15 
 68167 Mannheim 
 vertreten durch den Geschäftsführer Herr Jochen Mattis 
 - nachstehend
Mieterin genannt 
  

	1.	Änderung zu § 1 Mietgegenstand 

 Die Mietfläche wird um 57,65 m2 im 1. OG erweitert. Der Grundriss ist als Anlage 1 zum Nachtrag beigelegt. 
  

	3.	Änderung zu § 4 Mietzins, Nebenkosten und Mehrwertsteuer 

 Der Mietzins für das 1. OG setzt ab dem 01.02.2006 wie folgt zusammen: 
  

									
	Bürofläche seither	  	171,18 m2	  	x	  	[...***...]	  	[...***...]
	Bürofläche neu	  	57,65 m2	  	x	  	[...***...]	  	[...***...]
	4 Tiefgaragenstellplätze	  		  		  		  	[...***...]
	Nebenkostenvorauszahlung	  	228,83 m2	  	x	  	[...***...]	  	[...***...]
	Zwischensumme netto	  		  		  		  	[...***...]
	Mehrwertsteuer 16 %	  		  		  		  	[...***...]
	Summe brutto gesamt	  		  		  		  	[...***...]

  
  

***Confidential Treatment Requested 
  

			
	 Seite 1 des Nachtrags vom 07.12.2005
	  	

	4.	Sonstiges 

  

	 	1.	Der Vermieter übernimmt auf seine Kosten die Umverlegung der Strom- und Serverleitungen, sowie das Teppichverlegen der neu angemieteten Räume.

 Der Mieter übernimmt die Kosten der Verschiebung der Wande. 

 

	 	2.	Sämtliche übrigen Bestimmungen des Hauptmietvertrags vom 06.01.2005/ 22.12.2004 gelten unverändert fort. 

 

					
	Essen, den 30.01.06	 		 	Mannheim, den 13.01.06
			
	Alters- und Hinterbliebenen Versicherung	 		 	Fa. Nitec Pharma GmbH
	der Technischen Oberwachungsvereine VVAG	 		 	Joseph-Meyer-Str. 13-15
	Kurfürstenstr. 58	 		 	
	45138 Essen	 		 	68167 Mannheim
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Vermieterin)	 		 	(Mieterin)
	Alters- und Hinterbliebenen-Versicherungder Technischen Überwachungs-Vereine (VVAG)	 		 	
	Kronprinzenstr. 30 45128 Essen	 		 	

  
 Seite 2 des Nachtrags vom
07.12.2005 

 

 

  

 Nachtrag Nr. 2 zum Mietvertrag vom 06.01.2005 / 22.12.2004 

Objekt: Janus-Office-Center, 
 Josef-Meyer-Str. 13-15, 68167 Mannheim 
 zwischen 

Alters- und Hinterbliebenen-Versicherung der 

Technischen Überwachungs-Vereine VVaG 

Kronprinzenstr. 30 
 45128 Essen 

UST ID: DE 11 98 24807 
 Vertreten durch den
Vorstand Herr Dr. rer. pol. G. Wiedemann und Herr Ralf Heynck 
 UST ID: DE 11 98 24807 

und 
 Firma 

Nitec Pharma GmbH 
 Joseph-Meyer-Str. 13-15

 68167 Mannheim 
 vertreten durch
den Geschäftsführer Herr Dr. Achim Schäffler 
 - nachstehend Mieterin genannt - 

 

	1.	Änderung zu § 1 Mietgegenstand 

 Die Mietfläche wird ab 01.02.2007 um 214,17 m2 im 1. OG erweitert. Somit wird das komplette 1. OG von der Mieterin belegt. Die Gesamtfläche beträgt 443 m2. 
  

	2.	Änderung zu § 4 Mietzeit und Kündigung 

 Das Mietverhältnis veriängert sich ab 01.02.2007 für das komplette 1. OG um weitere 2 Jahre bis zum 31.01.2009 

 

	3.	Änderung zu § 5 Mietzins 

  

											
	 Kaltmiete Bürofläche 1. OG
	  	 	443 m2	  	  	á	  	[...***...]	  	[...***...]
	 Tiefgaragenplätze 125,126,127,128
	  				  		  		  	
	 Stellplätze Nr. 33+32
	  				  		  		  	[...***...]
		  				  		  		  	 
	 Summe Kaltmiete
	  				  		  		  	[...***...]
	 + Nebenkostenvorauszahlung
	  	 	443 m2	  	  	á	  	[...***...]	  	
		  				  		  		  	 
	 Summe Warmmiete netto

+ 19 % MwSt.
	  				  		  		  	[...***...]
		  				  		  		  	 
	 Summe gesamt
	  				  		  		  	[...***...]
		  				  		  		  	 

  
  

***Confidential Treatment Requested 
 Seite 1 des Nachtrags Nr. 2 AHV/Nitec 

	4.	Sonstiges 

  

	 	1.	Der Mieter übernimmt auf seine Kosten die Verlegung der Strom- und Serverleitungen, sowie den Abbruch der eingezogenen Wand. 

 

	 	2.	Der Vermieter übernimmt die Kosten für das Verlegen von Teppich in den neu angemieteten Räumen. 

 

	 	3.	Sämtliche übrigen Bestimmungen des Hauptmietvertrags vom 06.01.2005/ 22.12.2004 gelten unverändert fort. 

 

							
	Essen, den	 	  
	 		 	Mannheim, den 03. January 2007
			
	Alters- und Hinterbilebenen-Versicherung der	 		 	Fa. Nitec Pharma GmbH
	Technischen Überwachungs-Vereine-VVaG-	 		 	Joseph-Meyer-Str. 13-15
	Kronprinzenstr. 30	 		 	
			
	45128 Essen	 		 	68167 Mannheim
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Vermieterin)	 		 	(Mieterin)

  
 Seite 2 des Nachtrags Nr. 2
AHV/Nitec 

 Nachtrag Nr. 3 zum Mietvertrag vom 06.01.2005 / 22.12.2004 

Objekt: Janus-Office-Center, 
 Josef-Meyer-Str. 13-15, 68167 Mannheim 
 zwischen 

Alters- und Hinterbliebenen-Versicherung der 

Technischen Überwachungs-Vereine VVaG 

Kronprinzenstr. 30 
 45128 Essen 

UST ID: DE 11 98 24807 
 Vertreten durch den
Vorstand Herr Dr. rer. pol. G. Wiedemann und Herr Ralf Heynck 
 - nachstehend Vermieter genannt - 

und 
 Firma 

Nitec Pharma GmbH 
 Joseph-Meyer-Str. 13-15

 68167 Mannheim 
 vertreten durch
den Geschäftsführer Herr Dr. Achim Schäffler 
 - nachstehend Mieterin genannt - 

 

	1.	Änderung zu § 1 Mietgegenstand 

 Die Mietfläche wird ab 01.04.2008 um 247,29 m2 im 5. OG erweitert. 
 Somit beträgt die Gesamtfläche
neu 690,29 m2 (1. und 5. OG) 

 

	2.	Änderung zu § 5 Mietzins 

 Der Mietzins für setzt sich ab 01.04.08 wie folgt zusammen: 
  

																	
	 Kaltmiete Bürofläche 1. OG
	  	 	443,00 m2	  	  	 	á	  	  	 	[...***...]	  	  	 	[...***...]	  
	 Kaltmiete Bürofläche 5. OG
	  	 	247,29 m2	  	  	 	á	  	  	 	[...***...]	  	  	 	[...***...]	  
	 Tiefgaragenplätze 125,126,127,128,132,133
	  				  				  				  	 	[...***...]	  
	 Stellplätze Nr. 32+33+10+11+2
	  				  				  				  	 	[...***...]	  
		  				  				  				  	 	 	 
	 Summe Kaltmiete
	  				  				  				  	 	[...***...]	  
	 + Nebenkostenvorauszahlung
	  	 	690,29 m2	  	  	 	á	  	  	 	[...***...]	  	  	 	[...***...]	  
		  				  				  				  	 	 	 
	 Summe Warmmiete netto
	  				  				  				  	 	[...***...]	  
	 + 19 % MwSt.
	  				  				  				  	 	[...***...]	  
		  				  				  				  	 	 	 
	 Summe gesamt
	  				  				  				  	 	[...***...]	  
		  				  				  				  	 	 	 

  
  

***Confidential Treatment Requested 
 Seite 1 des Nachtrags Nr. 3 AHV/Nitec 

	4.	Sonstiges 

  

	 	1.	Der Mieter übernimmt auf seine Kosten die Malerarbeiten und Teppichreinigung in den Büroräumen im 5 OG. 

 

	 	2.	In Büroräumen, in welchen der Teppichboden sehr stark abgenutzt ist, ersetzt der Vermieter den Teppichboden. 

 

	 	3.	Der Vermieter übernimmt die Kosten einer Geschirrspülmaschine. 

  

	 	4.	Die Möbel im 5. OG gehen kostenfrei auf die Firma Nitec Pharrna über. 

 

	 	5.	Samtliche übrigen Bestimmungen des Hauptmietvertrags vom 06.01.2005/ 22.12.2004 gelten unverändert fort. 

 

					
	Essen, den                     	 		 	Mannheim, den 04, April 2008
			
	Alters- und Hinterbliebenen-Versicherung der	 		 	Fa. Nitec Pharma GmbH
	Technischen Überwachungs-Vereine VVaG	 		 	Joseph-Meyer-Str. 13-15
	Kronprinzenstr. 30	 		 	
			
	45128 Essen	 		 	68167 Mannheim
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Vermieterin)	 		 	(Meiterin)

 Anlage I: Grundriss 5. OG 

Anlage II: Stellplatze Tiefgarage und Erdgeschoss 

  
 Seite 2 des Nachtrags Nr. 2
AHV/Nitec 

 

 

  
 Seite 3 des Nachtrags Nr. 2
AHV/Nitec 

 

 

  
 Seite 5 des Nachtrags Nr. 2
AHV/Nitec 

 

 

  
 Seite 6 des Nachtrags Nr. 2
AHV/Nitec 

 7.1.5 
 Nachtrag Nr. 4 zum Mietvertrag vom 06.01.2005 / 22.12.2004 
 Objekt:
Janus-Office-Center,
 Josef-Meyer-Str. 13-15, 68167 Mannheim 
 Zwischen 
 Alters-und Hinterbliebenen-Versicherung der 

Technischen Überwachungs-Vereine VVaG 

Kronprinzenstr. 30 
 45128 Essen 

UST ID: DE 11 98 24807 
 Vertreten durch den
Vorstand Herr Dr. rer. pol. G. Wiedemann und Herr Ralf Heynck 
 - nachstehend Vermieter genannt - 

und 
 Firma 

Nitec Pharma GmbH 
 Joseph-Meyer-Str. 13-15

 68167 Mannheim 
 vertreten durch
den Geschäftsführer Herr Dr. Achim Schäffler 
 - nachstehend Mieterin genannt - 

 

	1.	Änderung zu § 4 Mietzeit und Kündigung 

 Das Mietverhältnis verlängert sich für die gesamte angemietete Fläche bis zum 31.12.2010. 
  

	2.	Sonstiges 

 Sämtliche
übrigen Bestimmungen des Hauptmietvertrags vom 06.01.2005/ 22.12.2004 nebst allen Nachträgen gelten unverändert fort. 
  

					
	Essen, den 24.09.2008	 		 	Mannheim, den 18 SEPT 2008
			
	 Alters- und Hinterbliebenen-Versicherung der
 Technischen Überwachungs-Vereine VVaG
 Kronprinzenstr. 30
	 		 	 Fa. Nitec Pharma GmbH

Joseph-Meyer-Str. 13-15

			
	45128 Essen	 		 	68167 Mannheim
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Vermieterin)	 		 	(Mieterin)

  
 Seite 1 des Nachtrags Nr. 4
AHV/Nitec 

 Nachtrag Nr. 5 zum Mietvertrag vom 06.01.2005/22.12.2004 

Objekt: Janus-Office-Center, 
 Josef-Meyer-Str. 13-15, 68167 Mannheim 
 Zwischen 

Alters- und Hinterbliebenen-Versicherung 
 der
Technischen Uberwachungs-Vereine VVaG 
 Kronprinzenstr. 30 
 45128 Essen 
 UST ID: DE 11 98 24807 
 Vertreten durch den Vorstand Herr Dr. rer pol. G Wiedemann and Herr Ralf Heynck 
 -
nachstehend Vermieter genannt - 
 und 

Firma 
 Nitec Pharma GmbH 

Joseph-Meyer-Str. 13-15 
 68167 Mannheim

 vertreten durch den Geshäftsführer Herr Dr. Achim Schäffler 
 - nachstehend Mieterin genannt - 
  

	1.	Änderung zu § 1 Mietsache 

 Die Mieterin mietet ab 01.04.2009 zusätzlich einen Lagerraum im Erdgeschoss an. 
  

	2.	Änderung zu § 5 Mietzins 

 Somit ended sich die monatliche Mietzahlung ab 01.04.09 wie folgt: 
  

											
	Kaltmiete Burof1äche 1. OG	  	443,00 m2	 	á	  	[...***...]	  	[...***...]	  	€
	Kaltmiete Buroffäche 5 OG	  	247,29 m2	 	á	  	[...***...]	  	[...***...]	  	€
	Lagerfläche EG	  	18,50 m2	 	á	  	[...***...]	  	[...***...]	  	€
	Tiefgaragenplätze 125,126,127,128,132,133	  		 		  		  	[...***...]	  	€
	Stellplatze Nr 32+33+10+11+2	  		 		  		  	[...***...]	  	€
		  		 		  		  	 	  	
	Summe Kaltmiete	  		 		  		  	[...***...]	  	€
	+ Nebenkostenvorauszahlung	  	690,29 m2	 	á	  	[...***...]	  	[...***...]	  	€
		  		 		  		  	 	  	
	Summe Warmmiete netto	  		 		  		  	7.487,85	  	€
	+ 19 % MwSt.	  		 		  		  	1.422,69	  	€
		  		 		  		  	 	  	
	Summe gesamt	  		 		  		  	8.910,55	  	€
		  		 		  		  	 	  	

  
  

***Confidential Treatment Requested 

 

	3,	Sonstiges 

 Samtliche
übrigen Bestimmungen des Hauptmietvertrags vom 06.01 2005/ 22 12.2004 nebst allen Nachirägen gelten unverandert fort 
  

					
	Essen, den 12.3.09	 		 	Mannheim, den 12.03.09
			
	Alters- und Hinterbliebenen-Versicherung der	 		 	Fa. Nitec Pharma GmbH
	Technischen Überwachungs-Vereine VVaG	 		 	Joseph-Meyer-Str. 13-15
	Kronprinzenstr. 30	 		 	
			
	45128 Essen	 		 	68167 Mannheim
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Vermieterin)	 		 	(Mieterin)
	Alters- und Hinterbliebenen-Versicherungder Technischen Überwachungs-Vereine (VVaG)	 		 	
	Kronprinzenstr. 30 45128 Essen	 		 	

  
 Seite 2 des Nachtrags Nr. 5
AHV/Nitec 

 Nachtrag Nr. 6 zum Mietvertrag vom 06.01.2005 / 22.12.2004 

Objekt: Janus-Office-Center, 
 Josef-Meyer-Str. 13-15, 68167 Mannheim 
 Zwischen 

Alters- und Hinterbliebenen-Versicherung der 

Technischen Überwachungs-Vereine-VVaG- 

Kurfürstenstr. 56, 45128 Essen 
 UST ID: DE
11 98 24807 
 Vertreten durch den Vorstand Herr R Heynck und Frau S. Schwierz 
 - nachstehend Vermieter genannt - 
 und 
 Firma 
 Horizon Pharma GmbH 
 ehemals Fa. Nitec Pharma GmbH 
 Joseph-Meyer-Str. 13-15, 68167 Mannheim 

vertreten durch den Geschäftsführer Herr Dr. Achim Schäffler 
 - nachstehend Mieterin genannt - 
 Präambel 

Die Fa. Nitec Pharma GmbH wurde am 22.06.2010 in Horizon Pharma GmbH umbenannt. Sämtliche Rechte und Pflichten aus dem bestehenden Mietvertrag gehen
somit zeitgleich auf die Firma Horizon Pharma GmbH über. 
  

	1.	Änderung zu § 4 Mietzeit und Kündigung 

 Das Mietverhältnis verlängert sich für die gesamte angemietete Fläche bis zum 31.12.2011. 
  

	2.	Sonstiges 

 Sämtliche
übrigen Bestimmungen des Hauptmietvertrags vom 06.01.2005/ 22.12.2004 nebst allen Nachträgen gelten unverändert fort. 
  

									
	 Essen, den
	  	26.8.2010	  		  	Mannheim, den	  	19.Aug.2010
			
	 Alters- und Hinterbliebenen-Versicherung der

Technischen Überwachungs-Vereine VVaG

Kronprlnzenstr.30
  

45128 Essen
	  		  	 Fa. Horizon Pharma GmbH
 Joseph-Meyer-Str. 13-15
  

68167 Manneheim

			
	 /s/ illegible
	  		  	/s/ Achim Schäffler
	 (Vermieterin)

Alters- und Hinterbliebenen-Versicherung der Technischen Überwachungs-Veriene (VVaG) Kurfürstenstr. 56 • 45138
Essen
	  		  	 (Mieterin)

  

							
	 Seite 1 des Nachtrags Nr. 6 AHV/Horizon

Sitz: München

Amtsgericht München HRB 89 260

HypoVereinsbank München 2 450 577

BLZ 700 202 70
 USt-IdNr. DE129484259
 Informationen gemäß
§ 2 Abs. 1 DL-InfoV
 unter www.tuev-sued.de/impressum
	 	 Geschäftsführer:
 Dipl.-Ing. Wolfgang Berger
 690580 v2/SD
	 	Telefon: +49 711 7005-211
 Telefax: +49 711 7005-312

www.tuev-sued.de
 TÜV®
	 	TÜV SÜD Immobilien Service GmbH

Gottlieb-Daimler-Straße 7
 70794
Filderstadt
 Deutschland

 7.1.4 
 Mietvertrag über 
 Stellplätze 

Joseph-Meyer-Str. 13-15, 68167 Mannheim 
 Zwischen 
 Alters-und Hinterbliebenen 
 Versicherung der 
 Technischen Uberwachungsvereine VVaG 

Kurfurstenstr. 56 
 45138 Essen 

UST ID: DE 11 98 24807 
 Vertreten durch den
Geschf. Vorstand Herr Dr. rer. Pol. G. Wiedemann 
 und 
 Firma 
 Nitec Pharma GmbH 
 Joseph-Meyer-Str. 13-15 
 68167 Mannheim 
 vertreten durch den Geschaftsführer Herr Jochen Mattis 
 -nachstehend Mieterin
genannt- 
  

	1.	Mietobjekt 

 Der Mieter
mietet ab 01.08.2007 in der Joseph-Meyer-Str. 13-15, 68167 Mannheim nachstehende Stellpätze an: 
  

							
	Stellplatz Nr. 10+11	  	á	  	[...***...]	  	[...***...]
	+ 16% MwSt.	  		  		  	[...***...]
		  		  		  	 
	monatliche Stellplatzmiete gesamt	  		  		  	[...***...]

  

	2.	Kündigung 

Der Mietvertrag kann von beiden Parteien mit einer Frist von 1 Monat gekündigt werden. 

  
  

***Confidential Treatment Requested 

					
	Filderstadt, den 07.08.07	 		 	Mannheim, den [Illegible]
			
	TUV SUD Immobillien Servico GmbH	 		 	 Nitec Pharma GmbH

Joseph-Meyer-Strafle 13-15
 68167
Mannheim

	[Illegible]	 		 	
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Vermieter)	 		 	(Mieter)

  
 2.

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00187-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00187-of-00352.parquet"}]]