Document:

Registration Rights Wavier

 Exhibit 4.9 
 

 
 PRIVATE AND CONFIDENTIAL 
 September 14, 2012 
 Dear Orexigen Therapeutics, Inc. Stockholder: 

Re: Notice of Registration and Request for Waiver pursuant to the Second Amended 

        and Restated Investors’ Rights Agreement dated as of November 20,
2006 
 Orexigen Therapeutics, Inc. (the “Company”) is proposing to file a Registration Statement on Form
S-3 to register $150,000,000 worth of securities with the Securities and Exchange Commission (the “Registration”). Pursuant to the terms of the Second Amended and Restated Investors’ Rights Agreement, dated as of
November 20, 2006, as amended to date (the “Investors’ Rights Agreement”), by and among the Company, you and the other investors party thereto (the “Investors”), you have certain rights to include your
Registrable Securities (as defined in the Investors’ Rights Agreement) in the Registration to the extent provided therein. 

We hereby give you notice pursuant to Section 1.3 of the Investors’ Rights Agreement that we intend to file a Registration
Statement on Form S-3 (including any amendment thereto, any abbreviated registration statement under Rule 462(b) and any successor registration statement under Rule 415(a)(6), collectively, the “Registration Statement”). We are
requesting that you waive, for and on behalf of all Investors, the right to any notice under the Investors’ Rights Agreement with respect to the Registration Statement, including without limitation any amendments and supplements thereto, and
any offering thereunder. 
 We are requesting that you waive, for and on behalf of all Investors, any right to include
Registrable Securities in the Registration Statement and any offering thereunder. Of course, the Investors’ demand registration rights will continue to apply, as will their rights to participate in future registration statements that we may
file, pursuant to the terms of the Investors’ Rights Agreement. 
 We kindly ask that you please sign and
date where indicated below and fax this executed letter to the attention of Mark Piesner, Latham & Watkins LLP at 858-523-3929 as soon as possible. 
 Please understand that our intention to register these securities has not been announced publicly and that we need your cooperation in keeping our intention confidential until we file the
Registration Statement. 
 Should you have any questions, please do not hesitate to contact me at (858) 875-8673.
Thank you. 
 Very truly yours, 
 /s/ Joseph P. Hagan, Chief Business Officer 

 THE UNDERSIGNED STOCKHOLDER HEREBY AGREES TO THE WAIVERS DESCRIBED ABOVE, ON BEHALF OF ITSELF AND ALL
INVESTORS. OUR RECEIPT OF SIGNED COPIES OF THIS LETTER FROM THE INVESTORS HOLDING AT LEAST TWO-THIRDS OF THE REGISTRABLE SECURITIES ENTITLED TO REGISTRATION UNDER THE INVESTORS’ RIGHTS AGREEMENT WILL CONSTITUTE AN EFFECTIVE WAIVER OF ALL
INVESTORS’ RIGHT TO INCLUDE REGISTRABLE SECURITIES IN THE REGISTRATION STATEMENT AND TO NOTICE OF THE FILING OF THE REGISTRATION STATEMENT. 
  

			
	
	
	Domain Partners V, L.P.
	By:	 	One Palmer Square Associates V, L.L.C.
		 	its General Partner

  

					
	
			
		 	  By:	 	/s/ Kathleen K. Schoemaker
		 		 	Kathleen K. Schoemaker,
		 		 	Managing Member

  

			
	
	
	DP V Associates, L.P.
	By:	 	One Palmer Square Associates V, L.L.C.
		 	its General Partner

  

					
	
			
		 	  By:	 	/s/ Kathleen K. Schoemaker
		 		 	Kathleen K. Schoemaker,
		 		 	Managing MemberSchedule of Omitted Agreements

 Exhibit 10.45 
 Schedule of Omitted Documents 
 of CNL Healthcare Trust, Inc.

 The following lease agreements were not filed as exhibits to Post-effective Amendment No. 1 filed with the
Commission on February 28, 2012 pursuant to Instruction 2 of Item 601 of Regulation S-K. These documents are substantially identical in all material respects to Exhibit 10.8 to said amendment. 

 

	 	1.	Primrose Retirement Community of Casper, Casper, Wyoming, Lease Agreement dated as of February 16, 2012, by and between CHT Casper WY Senior Living, LLC and TSMM
Management, LLC. 

  

	 	2.	Primrose Retirement Community of Grand Island, Grand Island, NE, Lease Agreement dated as of February 16, 2012, by and between CHT Grand Island NE Senior Living,
LLC and TSMM Management, LLC. 

  

	 	3.	Sweetwater Retirement Community, Billings, Montana, Lease Agreement dated as of February 16, 2012, by and between CHT Billings MT Senior Living, LLC and TSMM
Management, LLC. 

  

	 	4.	Primrose Retirement Community of Mansfield, Mansfield, OH, Lease Agreement dated as of February 16, 2012, by and between CHT Mansfield OH, LLC and TSMM Management,
LLC. 

 The following lease agreements were not filed as exhibits to the Form 8-K dated August 31, 2012,
filed with the Commission on September 7, 2012 pursuant to Instruction 2 of Item 601 of Regulation S-K. These documents are substantially identical in all material respects to Exhibit 10.4 to said report. 

 

	 	1.	Lease Agreement dated August 31, 2012, by and between Vinton IA Assisted Living Owner, LLC and Vinton IA Assisted Living Tenant, LLC. 

 

	 	2.	Lease Agreement dated August 31, 2012, by and between Nevada IA Assisted Living Owner, LLC and Nevada IA Assisted Living Tenant, LLC. 

The following mortgages were not filed as exhibits to Post-effective Amendment No. 1 filed with the Commission on February 28,
2012 pursuant to Instruction 2 of Item 601 of Regulation S-K. These documents are substantially identical in all material respects to Exhibit 10.12 to said amendment. 

 

	 	1.	Open-End Mortgage, Assignment of Rents, Security Agreement and Fixture Filing dated as of February 16, 2012, made by CHT Casper WY Senior Living, LLC, in favor of
KeyBank National Association. 

  

	 	2.	Open-End Mortgage, Assignment of Rents, Security Agreement and Fixture Filing dated as of February 16, 2012, made by CHT Grand Island NE Senior Living, LLC, in
favor of KeyBank National Association. 

  

	 	3.	Open-End Mortgage, Assignment of Rents, Security Agreement and Fixture Filing dates as of February 16, 2012, made by CHT Billings MT Senior Living, LLC, LLC, in
favor of KeyBank National Association. 

  

	 	4.	Open-End Mortgage, Assignment of Rents, Security Agreement and Fixture Filing dated as of February 16, 2012, made by CHT Mansfield OH Senior Living, LLC, in favor
of KeyBank National Association. 

 The following management agreements were not filed as exhibits to the
Quarterly Report on Form 10-Q for the period ended June 30, 2012, filed with the Commission on August 14, 2012 pursuant to Instruction 2 of Item 601 of Regulation S-K. These documents are substantially identical in all material
respects to Exhibit 10.4 to said report. 
  

	 	1.	Management Agreement (Sunrise at Siegen) dated as of June 29, 2012, by and among Sunrise Senior Living Management, Inc., CHTSun Two Baton Rouge LA Senior Living,
LLC and CHTSUN Partners IV, LLC. 

  

	 	2.	Management Agreement (Sunrise of Gilbert) dated as of June 29, 2012, by and among Sunrise Senior Living Management, Inc., CHTSun Two Gilbert AZ Senior Living, LLC
and CHTSUN Partners IV, LLC. 

	 	3.	Management Agreement (Sunrise of Santa Monica) dated as of June 29, 2012, by and among Sunrise Senior Living Management, Inc., AL Santa Monica Senior Housing, LP
and CHTSUN Partners IV, LLC. 

  

	 	4.	Management Agreement ((Sunrise of Metairie) dated as of June 29, 2012, by and among Sunrise Senior Living Management, Inc., CHTSun Two Metairie LA Senior Living,
LLC and CHTSUN Partners IV, LLC. 

  

	 	5.	Management Agreement (Sunrise of Louisville) dated as of June 29, 2012, by and among Sunrise Senior Living Management, Inc., Sunrise Louisville KY Senior Living,
LLC and CHTSUN Partners IV, LLC. 

  

	 	6.	Management Agreement (Sunrise at Fountain Square) dated as of June 29, 2012, by and among Sunrise Senior Living Management, Inc., CHTSun Three Lombard IL Senior
Living, LLC and CHTSUN Partners IV, LLC. 

 The following management agreements were not filed as exhibits to the
Form 8-K dated August 31, 2012, filed with the Commission on September 7, 2012 pursuant to Instruction 2 of Item 601 of Regulation S-K. These documents are substantially identical in all material respects to Exhibit 10.3 to said
report. 
  

	 	1.	Management Services Agreement dated August 31, 2012, by and between Provision Living, LLC and Vinton IA Assisted Living Tenant, LLC. 

 

	 	2.	Management Services Agreement dated August 31, 2012, by and between Provision Living, LLC and Nevada IA Assisted Living Tenant, LLC. 

The following promissory notes were not filed as exhibits to the Quarterly Report on Form 10-Q for the period ended June 30, 2012,
filed with the Commission on August 14, 2012 pursuant to Instruction 2 of Item 601 of Regulation S-K. These documents are substantially identical in all material respects to Exhibit 10.6 to said report. 

 

	 	1.	Promissory Note ($9,769,000) (Sunrise at Siegen) dated June 29, 2012, made by Baton Rouge LA Senior Living Owner, LLC and CHTSUN Two Baton Rouge LA Senior Living,
LLC in favor of The Prudential Insurance Company of America. 

  

	 	2.	Promissory Note ($33,932,000) (Sunrise of Connecticut Avenue) dated June 29, 2012, made by Sunrise Connecticut Avenue Assisted Living Owner, L.L.C. (f/k/a Sunrise
Connecticut Avenue Assisted Living, L.L.C.) in favor of The Prudential Insurance Company of America.  

  

	 	3.	Promissory Note ($21,068,000) (Sunrise of Santa Monica) dated June 29, 2012, made by Santa Monica Assisted Living Owner, LLC and AL Santa Monica Housing, LP in
favor of The Prudential Insurance Company of America. 

  

	 	4.	Promissory Note ($13,839,000) (Sunrise of Metairie) dated June 29, 2012, made by Metairie LA Senior Living Owner, LLC and CHTSun Two Metairie LA Senior Living, LLC
in favor of The Prudential Insurance Company of America. 

  

	 	5.	Promissory Note ($11,674,000) (Sunrise of Louisville) dated June 29, 2012, made by Louisville KY Senior Living Owner, LLC and Sunrise Louisville KY Senior Living,
LLC in favor of The Prudential Insurance Company of America. 

  

	 	6.	Promissory Note ($17,657,000) (Sunrise at Fountain Square) dated June 29, 2012, made by Lombard IL Senior Living Owner, LLC and CHTSun Three Lombard IL Senior
Living, LLC in favor of The Prudential Insurance Company of America. 

 The following promissory notes were not
filed as exhibits to Form 8-K dated August 31, 2012, filed with the Commission on September 7, 2012 pursuant to Instruction 2 of Item 601 of Regulation S-K. These documents are substantially identical in all material respects to
Exhibit 10.2 to said report. 
  

	 	1.	Multifamily Note ($11,031,000.00) dated as of August 31, 2012, made by CHT Billings MT Senior Living, LLC and Keycorp Real Estate Capital Markets, Inc.

  
 2 

	 	2.	Multifamily Note ($12,758,000.00) dated as of August 31, 2012, made by CHT Casper WY Senior Living, LLC and Keycorp Real Estate Capital Markets, Inc.

  

	 	3.	Multifamily Note ($12,245,000.00) dated as of August 31, 2012, made by CHT Mansfield OH Senior Living, LLC and Keycorp Real Estate Capital Markets, Inc.

  

	 	4.	Multifamily Note ($10,157,000.00) dated as of August 31, 2012, made by CHT Marion OH Senior Living, LLC and Keycorp Real Estate Capital Markets, Inc.

 The following deeds of trust and security agreements were not filed as exhibits to the Quarterly Report on Form
10-Q for the period ended June 30, 2012, filed with the Commission on August 14, 2012 pursuant to Instruction 2 of Item 601 of Regulation S-K. These documents are substantially identical in all material respects to Exhibit 10.7 to
said report. 
  

	 	1.	First Multiple Indebtedness Mortgage and Security Agreement (Sunrise at Siegen) dated as of June 29, 2012, made by Baton Rouge LA Senior Living Owner, LLC and
CHTSun Two Baton Rouge LA Senior Living, LLC (f/k/a MetSun Two Baton Rouge LA Senior Living, LLC) to The Prudential Insurance Company of America. 

  

	 	2.	First Amended and Restated Deed of Trust and Security Agreement (Sunrise of Connecticut Avenue) dated as of June 29, 2012, made by Sunrise Connecticut Avenue
Assisted Living Owner, L.L.C. (f/k/a Sunrise Connecticut Avenue Assisted Living, L.L.C.) to First American Title Insurance Company (Trustee) f/b/o the Prudential Insurance Company of America. 

 

	 	3.	First Amended and Restated Deed of Trust, Security Agreement and Fixture Filing (Sunrise of Santa Monica) dated as of June 29, 2012, made by Santa Monica Assisted
Living Owner, LLC and AL Santa Monica Senior Housing, LP to First American Title Insurance Company (Trustee) f/b/o The Prudential Insurance Company of America. 

 

	 	4.	First Multiple Indebtedness Mortgage and Security Agreement (Sunrise of Metairie) dated as of June 29, 2012, made by Metairie LA Senior Living Owner, LLC and
CHTSun Two Metairie LA Senior Living, LLC (f/k/a MetSun Two Metairie LA Senior Living, LLC) to The Prudential Insurance Company of America. 

  

	 	5.	First Mortgage and Security Agreement (Sunrise of Louisville) dated as of June 29, 2012, made by Louisville KY Senior Living Owner, LLC and Sunrise Louisville KY
Senior Living, LLC to The Prudential Insurance Company of America. 

  

	 	6.	First Mortgage and Security Agreement (Sunrise at Fountain Square) dated as of June 29, 2012, made by Lombard IL Senior Living Owner, LLC and CHTSun Three Lombard
IL Senior Living, LLC (f/k/a MetSun Three Lombard IL Senior Living, LLC) to The Prudential Insurance Company of America. 

  

	 	7.	Second Deed of Trust and Security Agreement (Sunrise of Gilbert) dated as of June 29, 2012 made by Gilbert AZ Senior Living Owner , LLC and CHTSun Two Gilbert AZ
Senior Living, LLC to First American Title Insurance Company (Trustee) f/b/o The Prudential Insurance Company of America. 

  

	 	8.	Second Multiple Indebtedness Mortgage and Security Agreement (Sunrise at Siegen) dated as of June 29, 2012, made by Baton Rouge LA Senior Living Owner, LLC and
CHTSun Two Baton Rouge LA Senior Living, LLC to The Prudential Insurance Company of America. 

  

	 	9.	Second Amended and Restated Deed of Trust and Security Agreement (Sunrise of Connecticut Avenue) dated as of June 29, 2012, made by Sunrise Connecticut Avenue
Assisted Living Owner, L.L.C. (f/k/a Sunrise Connecticut Avenue Assisted Living, L.L.C.) to First American Title Insurance Company (Trustee) f/b/o The Prudential Insurance Company of America. 

 

	 	10.	Second Amended and Restated Deed of Trust, Security Agreement and Fixture Filing (Sunrise of Santa Monica) dated as of June 29, 2012, made by Santa Monica Assisted
Living Owner, LLC and AL Santa Monica Senior Housing, LP to First American Title Insurance Company (Trustee) f/b/o The Prudential Insurance Company of America. 

  
 3 

	 	11.	Second Multiple Indebtedness Mortgage and Security Agreement (Sunrise at Metairie) dated as of June 29, 2012, made by Metairie LA Senior Living Owner, LLC and
CHTSun Two Metairie LA Senior Living, LLC (f/k/a MetSun Two Metairie LA Senior Living, LLC) to The Prudential Insurance Company of America. 

  

	 	12.	Second Mortgage and Security Agreement (Sunrise of Louisville) dated as of June 29, 2012, made by Louisville KY Senior Living Owner, LLC and Sunrise Louisville KY
Senior Living, LLC to The Prudential Insurance Company of America. 

  

	 	13.	Second Mortgage and Security Agreement (Sunrise at Fountain Square) dated as of June 29, 2012, made by Lombard IL Senior Living Owner, LLC and CHTSun Three Lombard
IL Senior Living, LLC (f/k/a MetSun Three Lombard IL Senior Living, LLC to The Prudential Insurance Company of America. 

 The following mortgage agreements were not filed as exhibits to the Form 8-K dated August 31, 2012, filed with the Commission on September 7, 2012 pursuant to Instruction 2 of Item 601 of
Regulation S-K. These documents are substantially identical in all material respects to Exhibit 10.4 to said report. 
  

	 	1.	Multifamily Deed of Trust, Assignment of Leases and Rents, Security Agreement and Fixture Filing (Nebraska) dated as of August 31, 2012, by CHT Grand Island NE
Senior Living, LLC to Chicago Title Insurance Company f/b/o Keycorp Real Estate Capital Markets, Inc. 

  

	 	2.	Multifamily Mortgage, Assignment of Leases and Rents, Security Agreement and Fixture Filing (Wyoming) dated as of August 31, 2012, by CHT Casper WY Senior Living,
LLC f/b/o Keycorp Real Estate Capital Markets, Inc. 

  

	 	3.	Open-End Multifamily Mortgage, Assignment of Leases and Rents, Security Agreement and Fixture Filing (Ohio) dated as of August 31, 2012, by CHT Mansfield OH Senior
Living, LLC f/b/o Keycorp Real Estate Capital Markets, Inc. 

  

	 	4.	Open-End Multifamily Mortgage, Assignment of Leases and Rents, Security Agreement and Fixture Filing (Ohio) dated as of August 31, 2012, by CHT Marion OH Senior
Living, LLC f/b/o Keycorp Real Estate Capital Markets, Inc. 

 The following mortgage agreements were not filed as
exhibits to the Form 8-K dated August 31, 2012, filed with the Commission on September 7, 2012 pursuant to Instruction 2 of Item 601 of Regulation S-K. These documents are substantially identical in all material respects to Exhibit
10.4 to said report. 
  

	 	1.	Mortgage, Assignment of Rents, Security Agreement and Fixture Filing dated August 31, 2012, made by Vinton IA Assisted Living Owner, LLC and Vinton IA Assisted
Living Tenant, LLC in favor of KeyBank National Association. 

  

	 	2.	Mortgage, Assignment of Rents, Security Agreement and Fixture Filing dated August 31, 2012, made by Nevada IA Assisted Living Owner, LLC and Nevada IA Assisted
Living Tenant, LLC in favor of KeyBank National Association. 

 The following recourse liabilities guaranties were
not filed as exhibits pursuant to the Quarterly Report on Form 10-Q for the period ended June 30, 2012, filed with the Commission on August 14, 2012 pursuant to Instruction 2 of Item 601 of Regulation S-K. These documents are
substantially identical in all material respects to Exhibit 10.8 to said report. 
  

	 	1.	Recourse Liabilities Guaranty (Sunrise at Siegen) dated June 29, 2012, given by CNL Healthcare Trust, Inc. and Sunrise Senior Living Investments, Inc. f/b/o The
Prudential Insurance Company of America. 

  
 4 

	 	2.	Amended and Restated Recourse Liabilities Guaranty (Sunrise of Connecticut Avenue) dated June 29, 2012, given by CNL Healthcare Trust, Inc. and Sunrise Senior
Living Investments, Inc. f/b/o The Prudential Insurance Company of America. 

  

	 	3.	Amended and Restated Recourse Liabilities Guaranty (Sunrise of Santa Monica) dated June 29, 2012, given by CNL Healthcare Trust, Inc. and Sunrise Senior Living
Investments, Inc. f/b/o The Prudential Insurance Company of America. 

  

	 	4.	Recourse Liabilities Guaranty (Sunrise of Metairie) dated June 29, 2012, given by CNL Healthcare Trust, Inc. and Sunrise Senior Living Investments, Inc. f/b/o The
Prudential Insurance Company of America. 

  

	 	5.	Recourse Liabilities Guaranty (Sunrise of Louisville) dated June 29, 2012, given by CNL Healthcare Trust, Inc. and Sunrise Senior Living Investments, Inc. f/b/o
The Prudential Insurance Company of America. 

  

	 	6.	Recourse Liabilities Guaranty (Sunrise at Fountain Square) dated June 29, 2012, given by CNL Healthcare Trust, Inc. and Sunrise Senior Living Investments, Inc.
f/b/o The Prudential Insurance Company of America. 

 The following non-recourse obligations were not filed as
exhibits to the Form 8-K dated August 31, 2012, filed with the Commission on September 7, 2012 pursuant to Instruction 2 of Item 601 of Regulation S-K. These documents are substantially identical in all material respects to Exhibit
10.3 to said report. 
  

	 	1.	Guaranty of Non-Recourse Obligations dated as of August 31, 2012, given by CNL Healthcare Trust, Inc. f/b/o Keycorp Real Estate Capital Markets, Inc.

  

	 	2.	Guaranty of Non-Recourse Obligations dated as of August 31, 2012, given by CNL Healthcare Trust, Inc. f/b/o Keycorp Real Estate Capital Markets, Inc.

  

	 	3.	Guaranty of Non-Recourse Obligations dated as of August 31, 2012, given by CNL Healthcare Trust, Inc. f/b/o Keycorp Real Estate Capital Markets, Inc.

  

	 	4.	Guaranty of Non-Recourse Obligations dated as of August 31, 2012, given by CNL Healthcare Trust, Inc. f/b/o Keycorp Real Estate Capital Markets, Inc.

 The following loan and security agreements were not filed as exhibits pursuant to the Form 8-K dated
August 31, 2012, filed with the Commission on September 7, 2012 pursuant to Instruction 2 of Item 601 of Regulation S-K. These documents are substantially identical in all material respects to Exhibit 10.1 to said report. 

 

	 	1.	Multifamily Loan and Security Agreement dated as of August 31, 2012, by and between CHT Billings MT Senior Living, LLC and Keycorp Real Estate Capital Markets,
Inc. 

  

	 	2.	Multifamily Loan and Security Agreement dated as of August 31, 2012, by and between CHT Casper WY Senior Living, LLC and Keycorp Real Estate Capital Markets, Inc.

  

	 	3.	Multifamily Loan and Security Agreement dated as of August 31, 2012, by and between CHT Mansfield OH Senior Living, LLC and Keycorp Real Estate Capital Markets,
Inc. 

  

	 	4.	Multifamily Loan and Security Agreement dated as of August 31, 2012, by and between CHT Marion OH Senior Living, LLC and Keycorp Real Estate Capital Markets, Inc.

  
 5

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