Document:

EXHIBIT 10.1

                         MODIFICATION AGREEMENT RELATING
                           TO REIMBURSEMENT AGREEMENTS

     Modification Agreement Relating to Reimbursement Agreements (this
"Amendment"), dated effective as of May 1, 2000, between NEOSE TECHNOLOGIES,
INC. (the "Borrower"), a corporation organized and existing under the laws of
the state of Delaware, and HUDSON UNITED BANK, JEFFERSON BANK DIVISION,
successor to JEFFERSON BANK (the "Bank"), a banking institution organized and
existing under the laws of the Commonwealth of Pennsylvania.

                                   WITNESSETH:

     A. The Borrower and the Bank are parties to a certain Reimbursement
Agreement dated as of March 1, 1997 entered into with regard to Montgomery
County Industrial Development Authority's $1,000,000 Variable Rate Demand
Revenue Bonds (Neose Technologies, Inc. Project), Series A of 1997 (the "Series
A Reimbursement Agreement").

     B. The Borrower and the Bank are also parties to a certain Reimbursement
Agreement dated as of March 1, 1997 entered into with regard to Montgomery
County Industrial Development Authority's $8,400,000 Federally Taxable Variable
Rate Demand Revenue Bonds (Neose Technologies, Inc. Project), Series B of 1997
(the "Series B Reimbursement Agreement", and together with the Series A
Reimbursement Agreement, the "Reimbursement Agreements").

     C. The Borrower has requested that the Reimbursement Agreements be amended
to modify certain financial covenants, and the parties have agreed to modify the
Reimbursement Agreements for those purposes on the terms and conditions
hereinafter provided.

     NOW, THEREFORE, in consideration of the foregoing and for other
consideration, the receipt and sufficiency of which is hereby acknowledged, the
parties hereto, intending to be legally bound, hereby agree as follows:

     1. Defined Terms. Unless otherwise defined herein, terms defined in the
Reimbursement Agreements are used herein as therein defined.

     2. Amendments to Reimbursement Agreements.

          (a)  The Series A Reimbursement Agreement is hereby amended as
               follows:

               (i)  Section 6.22 is amended and restated as follows:

               The Borrower will at all times maintain a "working capital
               position", as defined in accordance with GAAP, of an amount equal
               to at least two (2) times the amount of the outstanding principal
               on the Bonds. Unrestricted Cash, as such phrase is defined in
               Section 6.20 of the Series B Reimbursement Agreement, plus
               amounts held in the Bank's Pledge Account B, created under the
               Series B Reimbursement Agreement, may be included by the Borrower
               and its accountants in determining the Borrower's "working
               capital position." If the Borrower decides to comply with the
               provisions of Section 6.20 (c) of the Series B Reimbursement
               Agreement, upon the Borrower's compliance thereof to the
               satisfaction of the Bank, this covenant shall no longer be
               operative.

<PAGE>

          (b)  The Series B Reimbursement Agreement is hereby amended as
               follows:

               (i) Section 6.20 (a) is amended and restated as follows:

               The Borrower shall maintain all of its investment accounts, up to
               a maximum aggregate amount of $50,000,000 with the Custodial
               Bank. The Borrower shall maintain in such investment accounts
               created with the Custodial Bank a combined total of its
               unencumbered cash and liquid short term investments (investments
               with a remaining maturity of less than three years)
               ("Unrestricted Cash") in an amount which shall have a fair market
               value equal to at least two (2) times the amount of the
               outstanding principal on the Bonds. If the value of the
               Unrestricted Cash held by the Custodial Bank, from time to time,
               shall fall below a fair market value equal to two (2) times the
               amount of the outstanding principal on the Bonds (but not less
               than one and one-half (1 1/2) times the amount of the outstanding
               principal on the Bonds) the Custodial Bank, shall, in accordance
               with the Custodial Bank Agreement, immediately transfer an amount
               of the Unrestricted Cash, with a fair market value equal to fifty
               percent (50%) of the Letter of Credit Amount at that time, to the
               Bank, for deposit into the "Bank's Pledge Account B" which is
               hereby created. If the total fair market value of the
               Unrestricted Cash, together with the funds held in the Bank's
               Pledge Account B shall, from time to time be valued at a fair
               market value equal to less than one and one- half (1 1/2 ) times
               the amount of the outstanding principal on the Bonds, the
               Custodial Bank shall, in accordance with the Custodial Bank
               Agreement, immediately transfer an amount of Unrestricted Cash to
               the Bank for deposit into the Bank's Pledge Account B, so that
               the value of the total amount held in the Bank's Pledge Account B
               shall have a fair market value equal to one hundred percent
               (100%) of the Letter of Credit Amount at that time.

               (ii) Section 6.20(b) is amended and restated as follows:

               If, from time to time, after the transfer or transfers of
               Unrestricted Cash to the Bank's Pledge Account B described in (a)
               above, the Borrower is able to provide additional Unrestricted
               Cash to the Custodial Bank in: (i) an amount so that the fair
               market value of the Unrestricted Cash held by the Custodial Bank
               together with the funds held in the Bank's Pledge Account B shall
               have a fair market value equal to at least one and one-half (1
               1/2 ) times the amount of the outstanding principal on the Bonds,
               but less than two (2) times the amount of the outstanding
               principal on the Bonds, the Bank shall transfer an amount of the
               funds held in the Bank's Pledge Account B to the Custodial Bank,
               in order that the funds remaining in the Bank's Pledge Account B
               shall have a fair market value equal to fifty percent (50%) of
               the Letter of Credit Amount at that time; or (ii) an amount so
               that the fair market value of the Unrestricted Cash held by the
               Custodial Bank together with the funds held in the Bank's Pledge

<PAGE>

               Account B shall have a fair market value equal to at least two
               (2) times the amount of the outstanding principal on the Bonds,
               the Bank shall transfer the entire amount of funds held in the
               Bank's Pledge Account B to the Custodial Bank.

               (iii) Section 6.22 is amended and restated as follows:

               The Borrower will at all times maintain a "working capital
               position", as defined in accordance with GAAP, of an amount at
               least equal to two (2) times the amount of the outstanding
               principal on the Bonds. Unrestricted Cash plus amounts held in
               the Bank's Pledge Account B may be included by the Borrower and
               its accountants in determining the Borrower's "working capital
               position." If the Borrower decides to comply with the provisions
               of Section 6.20(c) hereof, upon the Borrower's compliance thereof
               to the satisfaction of the Bank, this covenant shall no longer be
               operative.

     3. Incorporation of Reimbursement Agreements. The parties acknowledge and
agree that this Amendment is incorporated into and made part of the
Reimbursement Agreements, the terms and provisions of which, unless expressly
modified herein, or unless no longer applicable by their terms, continue
unchanged and remain in full force and effect. To the extent that any term or
provision of this Amendment is or may be deemed expressly inconsistent with any
term or provision in the Reimbursement Agreements, the terms and provisions
hereof shall control.

     4. Miscellaneous.

        (a) The headings of any paragraphs of this Amendment are for convenience
only and shall not be used to interpret any provision hereof.

        (b) No modification hereof or any agreement referred to herein shall be
binding or enforceable unless in writing and signed on behalf of the party
against which enforcement is sought.

        (c) In the event that any one or more of the provisions contained in
this Amendment shall be found to be invalid, illegal or unenforceable in any
respect, the validity, legality and enforceability of the remaining provisions
contained herein shall not in any way be affected or impaired thereby.

        (d) This Amendment shall be binding upon and inure to the benefit of the
Borrower and the Bank and their respective successors and assigns.

<PAGE>

     IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be
duly executed and delivered by their proper and duly authorized officers as of
the day and year first above written.

                                     Borrower:

                                     NEOSE TECHNOLOGIES, INC.

                                     By: /s/ P. Sherrill Neff
                                         ---------------------------------------

                                     Title: President and COO
                                            ------------------------------------

                                     Bank:

                                     HUDSON UNITED BANK, JEFFERSON BANK DIVISION

                                     By: /s/ Kenneth R. Frappier
                                         ---------------------------------------

                                     Title: Senior Vice President
                                            ------------------------------------EXHIBIT 10.2

                         MODIFICATION AGREEMENT RELATING
                           TO CUSTODIAL BANK AGREEMENT

     Modification Agreement Relating to Custodial Bank Agreement (this
"Amendment"), dated effective as of May 1, 2000, by and among OFFITBANK (the
"Custodian"), a New York banking corporation, NEOSE TECHNOLOGIES, INC. (the
"Borrower"), a corporation organized and existing under the laws of the state of
Delaware, and HUDSON UNITED BANK, JEFFERSON BANK DIVISION, successor to
JEFFERSON BANK (the "Bank"), a banking institution organized and existing under
the laws of the Commonwealth of Pennsylvania.

                                   WITNESSETH:

     A. The Custodian, the Borrower and the Bank are parties to a certain
Custodial and Collateral Security Agreement dated as of March 20, 1997, entered
into in connection with the issuance of the Montgomery County Industrial
Development Authority's $8,400,000 Federally Taxable Variable Rate Demand
Revenue Bonds (Neose Technologies, Inc. Project), Series B of 1997 (the
"Custodial Bank Agreement").

     B. The Borrower has requested that the Custodial Bank Agreement be amended
to reduce the required minimum levels of liquid investments in an Investment
Account (as defined in the Custodial Bank Agreement) and a Collateral Account
(as defined in the Custodial Bank Agreement) and to modify certain other
financial covenants, and the parties have agreed to modify the Custodial Bank
Agreement for those purposes on the terms and conditions hereinafter provided.

     C. NOW, THEREFORE, in consideration of the foregoing and for other
consideration, the receipt and sufficiency of which is hereby acknowledged, the
parties hereto, intending to be legally bound, hereby agree as follows:

     1. Defined Terms. Unless otherwise defined herein, terms defined in the
Custodial Bank Agreement are used herein as therein defined.

     2. Amendments to Custodial Bank Agreement.

          (a)  Section 1 is amended and restated as follows:

               Borrower hereby agrees to open and maintain an investment account
               (the "Investment Account") with Custodian, comprised of, inter
               alia, the Securities hereafter described. The term "Securities"
               means unencumbered cash (including money market funds and the
               like), any obligation of the United States Treasury, Federal
               Agency Securities and other investment grade securities and
               repurchased transactions of any of the foregoing types of
               securities having a combined fair market value of at least an
               amount equal to two (2) times the amount of the outstanding
               principal on the Series B Bonds, and includes Securities now
               owned and/or hereafter acquired by Borrower, or a subsidiary
               wholly owned by Borrower and created for the purpose of
               investing, (and maintained in the Investment Account and/or the
               Collateral Account), as well as any and all proceeds of the
               foregoing. The Investment Account is identified in detail on
               Schedule "A" attached hereto and made apart hereof.

          (b)  Section 3 is amended and restated as follows:

               For ease in facilitating the instructions set forth herein, the
               "$4,2000,000" and "$8,400,000" amounts referenced below assume
               that Borrower's obligations to Bank pursuant to the Loan
               Documents are $8,400,000. If, at the close of any business day,
               Borrower's obligations under the Loan documents are greater or
               less than $8,4000,000, Bank will instruct Custodian, as needed,
               to transfer a proportionate share of Securities either from or to
               the Investment Account, to ensure that the remaining value of the
               Securities in the Collateral Account remains consistent with the
               amounts required pursuant to the Loan Documents.

<PAGE>

               (a) Borrower shall maintain in the Investment Account and/or the
               Collateral Account, as applicable, Securities which shall have an
               aggregate fair market value not less than an amount equal to two
               (2) times the amount of the outstanding principal on the Series B
               Bonds. If at any time the aggregate fair market value of the
               Securities in the Investment Account (based solely on Custodian's
               fair market valuation) falls below a fair market value equal to
               an amount equal to two (2) times the amount of the outstanding
               principal on the Series B Bonds (but not less than an amount
               equal to one and one-half (1 1/2 ) times the amount of the
               outstanding principal on the Series B Bonds), Custodian shall
               immediately and automatically, but in no event later than the
               next business day, transfer from the Investment Account to the
               Collateral Account, an amount of Securities such that the
               aggregate fair market value of the Securities in the Collateral
               Account is not less than $4,200,000. If, at any time, the sum of
               the aggregate fair market value of the Securities in the
               Investment Account and the aggregate fair market value of the
               Securities in the Collateral Account is less than an amount equal
               to one and one-half (1 1/2 ) times the amount of the outstanding
               principal on the Series B Bonds, Custodian shall immediately and
               automatically transfer from the Investment Account to the
               Collateral Account, an amount of Securities such that the
               aggregate fair market value of the Securities in the Collateral
               Account is not less than $8,4000,000. Bank hereby authorizes
               Custodian to accept instructions from Borrower with respect to
               the purchase, sale and distribution of Securities in the
               Investment Account, so long as the instructions from Borrower are
               not inconsistent with the terms and conditions of this Agreement.

               Failure of Custodian to transfer Securities from the Investment
               Account to the Collateral Account as set forth in this Agreement,
               within two (2) business days, shall constitute an event of
               default under this Agreement and the Loan Documents and shall
               result in Bank's option to make immediate demand for payment in
               full of all sums due under the Loan Documents, or to exercise any
               remedies available to Bank thereunder, or under any other Loan
               Document related thereto.

               (b) If, from time to time, after Custodian transfers Securities
               from the Investment Account to the Collateral Account as set
               forth in section 3(a) above, Borrower is able to provide
               additional Securities to Custodian in:

               (i) an amount so that the fair market value of the Securities in
               the Investment Account, together with the fair market value of
               the Securities in the Collateral Account shall have a fair market
               value equal to at least an amount equal to one and one-half
               (1 1/2) times the amount of the outstanding principal on the
               Series B Bonds, but less than an amount equal to two (2) times
               the amount of the outstanding principal on the Series B Bonds,
               Custodian shall transfer Securities from the Collateral Account
               to the Investment Account, in an amount such that the remaining
               fair market value of the Securities in the Collateral Account
               shall not be less than $4,200,000; or

               (ii) an amount so that the fair market value of the Securities in
               the Investment Account, together with the fair market value of
               the Securities in the Collateral Account shall have a fair market
               value equal to at least an amount equal to two (2) times the
               amount of the outstanding principal on the Series B Bonds,

<PAGE>

               Custodian shall transfer the entire balance of Securities in the
               Collateral Account to the Investment Account (unless Bank
               receives written notice from Borrower as set forth in section 5
               below).

               (c) In the event Borrower's obligations pursuant to the Loan
               Documents are less than $8,400,000 and Bank fails to give the
               instruction to Custodian within three (3) days thereafter as
               provided for herein, Borrower may give such notice and Custodian
               shall be entitled to rely thereon, upon approval of the Bank.

          (c)  The first sentence of Section 6 is deleted and replaced with the
               following: "The sum of the Securities in the Investment Account
               and the Collateral Account must at all times have a fair market
               value equal to at least two (2) times the amount of the
               outstanding principal on the Series B Bonds."

     3. Incorporation of Custodial Bank Agreement. The parties acknowledge and
agree that this Amendment is incorporated into and made part of the Custodial
Bank Agreement, the terms and provisions of which, unless expressly modified
herein, or unless no longer applicable by their terms, continue unchanged and
remain in full force and effect. To the extent that any term or provision of
this Amendment is or may be deemed expressly inconsistent with any term or
provision in the Custodial Bank Agreement, the terms and provisions hereof shall
control.

     4. Miscellaneous.

        (a) The headings of any paragraphs of this Amendment are for convenience
only and shall not be used to interpret any provision hereof.

        (b) No modification hereof or any agreement referred to herein shall be
binding or enforceable unless in writing and signed on behalf of the party
against which enforcement is sought.

        (c) In the event that any one or more of the provisions contained in
this Amendment shall be found to be invalid, illegal or unenforceable in any
respect, the validity, legality and enforceability of the remaining provisions
contained herein shall not in any way be affected or impaired thereby.

        (d) This Amendment shall be binding upon and inure to the benefit of the
Custodian, the Borrower and the Bank and their respective successors and
assigns.

<PAGE>

     IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be
duly executed and delivered by their proper and duly authorized officers as of
the day and year first above written.

<TABLE>
<S>                                                      <C>
Custodian:                                               Borrower:

OFFITBANK                                                NEOSE TECHNOLOGIES, INC.

By: Wallace Mathai-Davis                                 By: P. Sherrill Neff
    -------------------------------------------              ---------------------------------------

Title: Managing Director and Compliance Officer          Title: President and COO
       ----------------------------------------                 ------------------------------------

                                                         Bank:

                                                         HUDSON UNITED BANK, JEFFERSON BANK DIVISION

                                                         By: Kenneth R. Frappier
                                                             ---------------------------------------

                                                         Title: Senior Vice President
                                                                ------------------------------------
</TABLE>

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