Document:

exv10w4

 

Exhibit 10.4

Alexza Pharmaceuticals, Inc.

2005 Equity Incentive Plan

Adopted
as Amended and Restated 2001 Equity Incentive Plan July 20,
2001

Adopted as Amended and Restated 2002 Equity Incentive Plan
May 30, 2002

Amended and Restated by
Board as 2005 Equity Incentive Plan:
December 7, 2005

Amended and Restated Plan Approved by the Stockholders:                     , 2006

Termination Date: December 7, 2015

1. General.

     (a) Eligible Stock Award Recipients. The persons eligible to receive Stock Awards are
Employees, Directors and Consultants.

     (b) Available Stock Awards. The Plan provides for the grant of the following Stock Awards:
(i) Incentive Stock Options, (ii) Nonstatutory Stock Options, (iii) Stock Purchase Awards, (iv)
Stock Bonus Awards, (v) Stock Appreciation Rights, (vi) Stock Unit Awards, and (vii) Other Stock
Awards.

     (c) Purpose. The Company, by means of the Plan, seeks to secure and retain the services of
the group of persons eligible to receive Stock Awards as set forth in Section 1(a), to provide
incentives for such persons to exert maximum efforts for the success of the Company and any
Affiliate and to provide a means by which such eligible recipients may be given an opportunity to
benefit from increases in value of the Common Stock through the granting of Stock Awards.

2. Definitions.

     As used in the Plan, the following definitions shall apply to the capitalized terms indicated
below:

     (a) “Affiliate” means (i) any corporation (other than the Company) in an unbroken chain of
corporations ending with the Company, provided each corporation in the unbroken chain (other than
the Company) owns, at the time of the determination, stock possessing fifty percent (50%) or more
of the total combined voting power of all classes of stock in one of the other corporations in such
chain, and (ii) any corporation (other than the Company) in an unbroken chain of corporations
beginning with the Company, provided each corporation (other than the last corporation) in the
unbroken chain owns, at the time of the determination, stock possessing fifty percent (50%) or more
of the total combined voting power of all classes of stock in one of the other corporations in such
chain. The Board shall have the authority to determine (i) the time or times at which the
ownership tests are applied, and (ii) whether “Affiliate” includes entities other than corporations
within the foregoing definition.

     (b) “Board” means the Board of Directors of the Company.

     (c) “Capitalization Adjustment” has the meaning ascribed to that term in Section 10(a).

1.

 

     (d) “Change in Control” means the occurrence, in a single transaction or in a series of
related transactions, of any one or more of the following events:

          (i) any Exchange Act Person becomes the Owner, directly or indirectly, of securities of the
Company representing more than fifty percent (50%) of the combined voting power of the Company’s
then outstanding securities other than by virtue of a merger, consolidation or similar transaction.
Notwithstanding the foregoing, a Change in Control shall not be deemed to occur (A) on account of
the acquisition of securities of the Company by an investor, any affiliate thereof or any other
Exchange Act Person from the Company in a transaction or series of related transactions the primary
purpose of which is to obtain financing for the Company through the issuance of equity securities
or (B) solely because the level of Ownership held by any Exchange Act Person (the “Subject Person”)
exceeds the designated percentage threshold of the outstanding voting securities as a result of a
repurchase or other acquisition of voting securities by the Company reducing the number of shares
outstanding, provided that if a Change in Control would occur (but for the operation of this
sentence) as a result of the acquisition of voting securities by the Company, and after such share
acquisition, the Subject Person becomes the Owner of any additional voting securities that,
assuming the repurchase or other acquisition had not occurred, increases the percentage of the then
outstanding voting securities Owned by the Subject Person over the designated percentage threshold,
then a Change in Control shall be deemed to occur;

          (ii) there is consummated a merger, consolidation or similar transaction involving (directly
or indirectly) the Company and, immediately after the consummation of such merger, consolidation or
similar transaction, the stockholders of the Company immediately prior thereto do not Own, directly
or indirectly, either (A) outstanding voting securities representing more than fifty percent (50%)
of the combined outstanding voting power of the surviving Entity in such merger, consolidation or
similar transaction or (B) more than fifty percent (50%) of the combined outstanding voting power
of the parent of the surviving Entity in such merger, consolidation or similar transaction, in each
case in substantially the same proportions as their Ownership of the outstanding voting securities
of the Company immediately prior to such transaction;

          (iii) the stockholders of the Company approve or the Board approves a plan of complete
dissolution or liquidation of the Company, or a complete dissolution or liquidation of the Company
shall otherwise occur;

          (iv) there is consummated a sale, lease, exclusive license or other disposition of all or
substantially all of the consolidated assets of the Company and its Subsidiaries, other than a
sale, lease, license or other disposition of all or substantially all of the consolidated assets of
the Company and its Subsidiaries to an Entity, more than fifty percent (50%) of the combined voting
power of the voting securities of which are Owned by stockholders of the Company in substantially
the same proportions as their Ownership of the outstanding voting securities of the Company
immediately prior to such sale, lease, license or other disposition; or

          (v) individuals who, on the date this Plan is adopted by the Board, are members of the Board
(the “Incumbent Board”) cease for any reason to constitute at least a majority of the members of
the Board; provided, however, that if the appointment or election (or

2.

 

nomination for election) of any new Board member was approved or recommended by a majority
vote of the members of the Incumbent Board then still in office, such new member shall, for
purposes of this Plan, be considered as a member of the Incumbent Board.

     The term Change in Control shall not include a sale of assets, merger or other transaction
effected exclusively for the purpose of changing the domicile of the Company.

     Notwithstanding the foregoing or any other provision of this Plan, the definition of Change in
Control (or any analogous term) in an individual written agreement between the Company or any
Affiliate and the Participant shall supersede the foregoing definition with respect to Stock Awards
subject to such agreement; provided, however, that if no definition of Change in Control or any
analogous term is set forth in such an individual written agreement, the foregoing definition shall
apply.

     (e) “Code” means the Internal Revenue Code of 1986, as amended.

     (f) “Committee” means a committee of one (1) or more members of the Board to whom authority
has been delegated by the Board in accordance with Section 3(c).

     (g) “Common Stock” means the common stock of the Company.

     (h) “Company” means Alexza Pharmaceuticals, Inc., a Delaware corporation.

     (i) “Consultant” means any person, including an advisor, who is (i) engaged by the Company or
an Affiliate to render consulting or advisory services and is compensated for such services, or
(ii) serving as a member of the Board of Directors of an Affiliate and is compensated for such
services. However, service solely as a Director, or payment of a fee for such service, shall not
cause a Director to be considered a “Consultant” for purposes of the Plan.

     (j) “Continuous Service” means that the Participant’s service with the Company or an
Affiliate, whether as an Employee, Director or Consultant, is not interrupted or terminated. A
change in the capacity in which the Participant renders service to the Company or an Affiliate as
an Employee, Consultant or Director or a change in the entity for which the Participant renders
such service, provided that there is no interruption or termination of the Participant’s service
with the Company or an Affiliate, shall not terminate a Participant’s Continuous Service; provided,
however, if the corporation for which a Participant is rendering service ceases to qualify as an
Affiliate, as determined by the Board in its sole discretion, such Participant’s Continuous Service
shall be considered to have terminated on the date such corporation ceases to qualify as an
Affiliate. For example, a change in status from an employee of the Company to a consultant of an
Affiliate or to a Director shall not constitute an interruption of Continuous Service. To the
extent permitted by law, the Board or the chief executive officer of the Company, in that party’s
sole discretion, may determine whether Continuous Service shall be considered interrupted in the
case of any leave of absence approved by that party, including sick leave, military leave or any
other personal leave. Notwithstanding the foregoing, a leave of absence shall be treated as
Continuous Service for purposes of vesting in a Stock Award only to such extent as may be provided
in the Company’s leave of absence policy or in the written terms of the Participant’s leave of
absence.

3.

 

     (k) “Corporate Transaction” means the occurrence, in a single transaction or in a series of
related transactions, of any one or more of the following events:

          (i) a sale or other disposition of all or substantially all, as determined by the Board in its
sole discretion, of the consolidated assets of the Company and its Subsidiaries;

          (ii) a sale or other disposition of a majority of the outstanding securities of the Company;

          (iii) the consummation of a merger, consolidation or similar transaction following which the
Company is not the surviving corporation; or

          (iv) the consummation of a merger, consolidation or similar transaction following which the
Company is the surviving corporation but the shares of Common Stock outstanding immediately
preceding the merger, consolidation or similar transaction are converted or exchanged by virtue of
the merger, consolidation or similar transaction into other property, whether in the form of
securities, cash or otherwise.

     (l) “Covered Employee” means the chief executive officer and the four (4) other highest
compensated officers of the Company for whom total compensation is required to be reported to
stockholders under the Exchange Act, as determined for purposes of Section 162(m) of the Code.

     (m) “Director” means a member of the Board.

     (n) “Disability” means the permanent and total disability of a person within the meaning of
Section 22(e)(3) of the Code.

     (o) “Employee” means any person employed by the Company or an Affiliate. However, service
solely as a Director, or payment of a fee for such services, shall not cause a Director to be
considered an “Employee” for purposes of the Plan.

     (p) “Entity” means a corporation, partnership or other entity.

     (q) “Exchange Act” means the Securities Exchange Act of 1934, as amended.

     (r) “Exchange Act Person” means any natural person, Entity or “group” (within the meaning of
Section 13(d) or 14(d) of the Exchange Act), except that “Exchange Act Person” shall not include
(i) the Company or any Subsidiary of the Company, (ii) any employee benefit plan of the Company or
any Subsidiary of the Company or any trustee or other fiduciary holding securities under an
employee benefit plan of the Company or any Subsidiary of the Company, (iii) an underwriter
temporarily holding securities pursuant to an offering of such securities, (iv) an Entity Owned,
directly or indirectly, by the stockholders of the Company in substantially the same proportions as
their Ownership of stock of the Company; or (v) any natural person, Entity or “group” (within the
meaning of Section 13(d) or 14(d) of the Exchange Act) that, as of the effective date of the Plan
as set forth in Section 13, is the Owner, directly or indirectly, of securities of the Company
representing more than fifty percent (50%) of the combined voting power of the Company’s then
outstanding securities.

4.

 

     (s) “Fair Market Value” means, as of any date, the value of the Common Stock determined as
follows:

          (i) If the Common Stock is listed on any established stock exchange or traded on the Nasdaq
National Market or the Nasdaq SmallCap Market, the Fair Market Value of a share of Common Stock
shall be the closing sales price for such stock (or the closing bid, if no sales were reported) as
quoted on such exchange or market (or the exchange or market with the greatest volume of trading in
the Common Stock) on the date in question, as reported in The Wall Street Journal or such other
source as the Board deems reliable. Unless otherwise provided by the Board, if there is no closing
sales price (or closing bid if no sales were reported) for the Common Stock on the date in
question, then the Fair Market Value shall be the closing sales price (or closing bid if no sales
were reported) on the last preceding date for which such quotation exists.

          (ii) In the absence of such markets for the Common Stock, the Fair Market Value shall be
determined by the Board in good faith.

     (t) “Incentive Stock Option” means an Option intended to qualify as an incentive stock option
within the meaning of Section 422 of the Code and the regulations promulgated thereunder.

     (u) “IPO Date” means the date of the underwriting agreement between the Company and the
underwriter(s) managing the initial public offering of the Common Stock, pursuant to which the
Common Stock is priced for the initial public offering.

     (v) “Non-Employee Director” means a Director who either (i) is not a current employee or
officer of the Company or an Affiliate, does not receive compensation, either directly or
indirectly, from the Company or an Affiliate for services rendered as a consultant or in any
capacity other than as a Director (except for an amount as to which disclosure would not be
required under Item 404(a) of Regulation S-K promulgated pursuant to the Securities Act
(“Regulation S-K”)), does not possess an interest in any other transaction for which disclosure
would be required under Item 404(a) of Regulation S-K, and is not engaged in a business
relationship for which disclosure would be required pursuant to Item 404(b) of Regulation S-K; or
(ii) is otherwise considered a “non-employee director” for purposes of Rule 16b-3.

     (w) “Nonstatutory Stock Option” means an Option not intended to qualify as an Incentive Stock
Option.

     (x) “Officer” means a person who is an officer of the Company within the meaning of Section 16
of the Exchange Act and the rules and regulations promulgated thereunder.

     (y) “Option” means an Incentive Stock Option or a Nonstatutory Stock Option to purchase shares
of Common Stock granted pursuant to the Plan.

     (z) “Option Agreement” means a written agreement between the Company and an Optionholder
evidencing the terms and conditions of an Option grant. Each Option Agreement shall be subject to
the terms and conditions of the Plan.

5.

 

     (aa) “Optionholder” means a person to whom an Option is granted pursuant to the Plan or, if
applicable, such other person who holds an outstanding Option.

     (bb) “Other Stock Award” means an award based in whole or in part by reference to the Common
Stock which is granted pursuant to the terms and conditions of Section 7(f).

     (cc) “Other Stock Award Agreement” means a written agreement between the Company and a holder
of an Other Stock Award evidencing the terms and conditions of an Other Stock Award grant. Each
Other Stock Award Agreement shall be subject to the terms and conditions of the Plan.

     (dd) “Outside Director” means a Director who either (i) is not a current employee of the
Company or an “affiliated corporation” (within the meaning of Treasury Regulations promulgated
under Section 162(m) of the Code), is not a former employee of the Company or an “affiliated
corporation” who receives compensation for prior services (other than benefits under a
tax-qualified retirement plan) during the taxable year, has not been an officer of the Company or
an “affiliated corporation,” and does not receive remuneration from the Company or an “affiliated
corporation,” either directly or indirectly, in any capacity other than as a Director, or (ii) is
otherwise considered an “outside director” for purposes of Section 162(m) of the Code.

     (ee) “Own,” “Owned,” “Owner,” “Ownership” A person or Entity shall be deemed to “Own,” to
have “Owned,” to be the “Owner” of, or to have acquired “Ownership” of securities if such person or
Entity, directly or indirectly, through any contract, arrangement, understanding, relationship or
otherwise, has or shares voting power, which includes the power to vote or to direct the voting,
with respect to such securities.

     (ff) “Participant” means a person to whom a Stock Award is granted pursuant to the Plan or, if
applicable, such other person who holds an outstanding Stock Award.

     (gg) “Performance Criteria” means the one or more criteria that the Board shall select for
purposes of establishing the Performance Goals for a Performance Period. The Performance Criteria
that shall be used to establish such Performance Goals may be based on any one of, or combination
of, the following: (i) earnings per share; (ii) earnings before interest, taxes and depreciation;
(iii) earnings before interest, taxes, depreciation and amortization (EBITDA); (iv) net earnings;
(v) return on equity; (vi) return on assets, investment, or capital employed; (vii) operating
margin; (viii) gross margin; (ix) operating income; (x) net income (before or after taxes); (xi)
net operating income; (xii) net operating income after tax; (xiii) pre- and after-tax income; (xiv)
pre-tax profit; (xv) operating cash flow; (xvi) sales or revenue targets; (xvii) increases in
revenue or product revenue; (xvii) expenses and cost reduction goals; (xix) improvement in or
attainment of expense levels; (xx) improvement in or attainment of working capital levels; (xxi)
economic value added; (xxii) market share; (xxiii) cash flow; (xxiv) cash flow per share; (xxv)
share price performance; (xxvi) debt reduction; (xxvii) implementation or completion of projects or
processes; (xxviii) customer satisfaction; (xxix) total stockholder return; (xxx) stockholders’
equity; and (xxxi) other measures of performance selected by the Board. Partial achievement of the
specified criteria may result in the payment or vesting corresponding to the degree of achievement
as specified in the Stock

6.

 

Award Agreement. The Board shall, in its sole discretion, define the manner of calculating
the Performance Criteria it selects to use for such Performance Period.

     (hh) “Performance Goals” means, for a Performance Period, the one or more goals established by
the Board for the Performance Period based upon the Performance Criteria. Performance Goals may be
based on a Company-wide basis, with respect to one or more business units, divisions, Affiliates,
or business segments, and in either absolute terms or relative to the performance of one or more
comparable companies or a relevant index. The Board is authorized to make adjustments in the
method of calculating the attainment of Performance Goals for a Performance Period as follows: (i)
to exclude restructuring and/or other nonrecurring charges; (ii) to exclude exchange rate effects,
as applicable, for non-U.S. dollar denominated net sales and operating earnings; (iii) to exclude
the effects of changes to generally accepted accounting standards required by the Financial
Accounting Standards Board; (iv) to exclude the effects of any statutory adjustments to corporate
tax rates; and (v) to exclude the effects of any “extraordinary items” as determined under
generally accepted accounting principles. The Board also retains the discretion to reduce or
eliminate the compensation or economic benefit due upon attainment of Performance Goals.

     (ii) “Performance Period” means the one or more periods of time, which may be of varying and
overlapping durations, as the Committee may select, over which the attainment of one or more
Performance Goals will be measured for the purpose of determining a Participant’s right to and the
payment of a Stock Award.

     (jj) “Performance Stock Award” means an award of shares of Common Stock which is granted
pursuant to the terms and conditions of Section 7(e).

     (kk) “Plan” means this Alexza Pharmaceuticals, Inc. 2005 Equity Incentive Plan.

     (ll) “Prior Plans” means the Company’s 2001 Equity Incentive Plan and 2002 Equity Incentive
Plan in effect immediately prior to the effective date of the Plan as set forth in Section 13.

     (mm) “Rule 16b-3” means Rule 16b-3 promulgated under the Exchange Act or any successor to Rule
16b-3, as in effect from time to time.

     (nn) “Securities Act” means the Securities Act of 1933, as amended.

     (oo) “Stock Appreciation Right” means a right to receive the appreciation on Common Stock that
is granted pursuant to the terms and conditions of Section 7(d).

     (pp) “Stock Appreciation Right Agreement” means a written agreement between the Company and a
holder of a Stock Appreciation Right evidencing the terms and conditions of a Stock Appreciation
Right grant. Each Stock Appreciation Right Agreement shall be subject to the terms and conditions
of the Plan.

     (qq) “Stock Award” means any right granted under the Plan, including an Option, a Stock
Purchase Award, Stock Bonus Award, a Stock Appreciation Right, a Stock Unit Award, Performance
Stock Award, or any Other Stock Award.

7.

 

     (rr) “Stock Award Agreement” means a written agreement between the Company and a Participant
evidencing the terms and conditions of a Stock Award grant. Each Stock Award Agreement shall be
subject to the terms and conditions of the Plan.

     (ss) “Stock Bonus Award” means an award of shares of Common Stock which is granted pursuant to
the terms and conditions of Section 7(b).

     (tt) “Stock Bonus Award Agreement” means a written agreement between the Company and a holder
of a Stock Bonus Award evidencing the terms and conditions of a Stock Bonus Award grant. Each
Stock Bonus Award Agreement shall be subject to the terms and conditions of the Plan.

     (uu) “Stock Purchase Award” means an award of shares of Common Stock which is granted pursuant
to the terms and conditions of Section 7(a).

     (vv) “Stock Purchase Award Agreement” means a written agreement between the Company and a
holder of a Stock Purchase Award evidencing the terms and conditions of a Stock Purchase Award
grant. Each Stock Purchase Award Agreement shall be subject to the terms and conditions of the
Plan.

     (ww) “Stock Unit Award” means a right to receive shares of Common Stock which is granted
pursuant to the terms and conditions of Section 7(c).

     (xx) “Stock Unit Award Agreement” means a written agreement between the Company and a holder
of a Stock Unit Award evidencing the terms and conditions of a Stock Unit Award grant. Each Stock
Unit Award Agreement shall be subject to the terms and conditions of the Plan.

     (yy) “Subsidiary” means, with respect to the Company, (i) any corporation of which more than
fifty percent (50%) of the outstanding capital stock having ordinary voting power to elect a
majority of the board of directors of such corporation (irrespective of whether, at the time, stock
of any other class or classes of such corporation shall have or might have voting power by reason
of the happening of any contingency) is at the time, directly or indirectly, Owned by the Company,
and (ii) any partnership in which the Company has a direct or indirect interest (whether in the
form of voting or participation in profits or capital contribution) of more than fifty percent
(50%).

     (zz) “Ten Percent Stockholder” means a person who Owns (or is deemed to Own pursuant to
Section 424(d) of the Code) stock possessing more than ten percent (10%) of the total combined
voting power of all classes of stock of the Company or any Affiliate.

3. Administration.

     (a) Administration by Board. The Board shall administer the Plan unless and until the Board
delegates administration of the Plan to a Committee, as provided in Section 3(c).

8.

 

     (b) Powers of Board. The Board shall have the power, subject to, and within the limitations
of, the express provisions of the Plan:

          (i) To determine the provisions of each Stock Award to the extent not specified in the Plan.

          (ii) To construe and interpret the Plan and Stock Awards granted under it, and to establish,
amend and revoke rules and regulations for its administration. The Board, in the exercise of this
power, may correct any defect, omission or inconsistency in the Plan or in any Stock Award
Agreement, in a manner and to the extent it shall deem necessary or expedient to make the Plan
fully effective.

          (iii) To determine from time to time (1) which of the persons eligible under the Plan shall be
granted Stock Awards; (2) when and how each Stock Award shall be granted; (3) what type or
combination of types of Stock Award shall be granted; (4) the provisions of each Stock Award
granted (which need not be identical), including the time or times when a person shall be permitted
to receive cash or Common Stock pursuant to a Stock Award; and (5) the number of shares of Common
Stock with respect to which a Stock Award shall be granted to each such person.

          (iv) To accelerate the time at which a Stock Award may first be exercised or the time during
which a Stock Award or any part thereof will vest in accordance with the Plan, notwithstanding the
provisions in the Stock Award stating the time at which it may first be exercised or the time
during which it will vest.

          (v) To effect, at any time and from time to time, with the consent of any adversely affected
Optionholder, (1) the reduction of the exercise price of any outstanding Option under the Plan; (2)
the cancellation of any outstanding Option under the Plan and the grant in substitution therefor of
(a) a new Option under the Plan or another equity plan of the Company covering the same or a
different number of shares of Common Stock, (b) a Stock Purchase Award, (c) a Stock Bonus Award,
(d) a Stock Appreciation Right, (e) a Stock Unit Award, (f) an Other Stock Award, (g) cash, and/or
(h) other valuable consideration (as determined by the Board, in its sole discretion); or (3) any
other action that is treated as a repricing under generally accepted accounting principles.

          (vi) To amend the Plan or a Stock Award as provided in Section 11.

          (vii) To terminate or suspend the Plan as provided in Section 12.

          (viii) Generally, to exercise such powers and to perform such acts as the Board deems
necessary or appropriate to promote the best interests of the Company which are not in conflict
with the provisions of the Plan.

          (ix) To adopt such procedures and sub-plans as are necessary or appropriate to permit
participation in the Plan by Employees who are foreign nationals or employed outside the United
States.

9.

 

     (c) Delegation to Committee.

          (i) General. The Board may delegate some or all of the administration of the Plan to a
Committee or Committees. If administration is delegated to a Committee, the Committee shall have,
in connection with the administration of the Plan, the powers theretofore possessed by the Board
that have been delegated to the Committee, including the power to delegate to a subcommittee any of
the administrative powers the Committee is authorized to exercise (and references in this Plan to
the Board shall thereafter be to the Committee or subcommittee), subject, however, to such
resolutions, not inconsistent with the provisions of the Plan, as may be adopted from time to time
by the Board. The Board may retain the authority to concurrently administer the Plan with the
Committee and may, at any time, revest in the Board some or all of the powers previously delegated.

          (ii) Section 162(m) and Rule 16b-3 Compliance. In the sole discretion of the Board, the
Committee may consist solely of two (2) or more Outside Directors, in accordance with Section
162(m) of the Code, and/or solely of two or more Non-Employee Directors, in accordance with Rule
16b-3. In addition, the Board or the Committee, in its sole discretion, may (1) delegate to a
committee of one or more members of the Board who need not be Outside Directors the authority to
grant Stock Awards to eligible persons who are either (a) not then Covered Employees and are not
expected to be Covered Employees at the time of recognition of income resulting from such Stock
Award, or (b) not persons with respect to whom the Company wishes to comply with Section 162(m) of
the Code, and/or (2) delegate to a committee of one or more members of the Board who need not be
Non-Employee Directors the authority to grant Stock Awards to eligible persons who are not then
subject to Section 16 of the Exchange Act.

     (d) Delegation to an Officer. The Board may delegate to one or more Officers of the Company
the authority to do one or both of the following (i) designate Officers and Employees of the
Company or any of its Subsidiaries to be recipients of Stock Awards and the terms thereof, and (ii)
determine the number of shares of Common Stock to be subject to such Stock Awards granted to such
Officers and Employees; provided, however, that the Board resolutions regarding such delegation
shall specify the total number of shares of Common Stock that may be subject to the Stock Awards
granted by such Officer and that such Officer may not grant a Stock Award to himself or herself.
Notwithstanding anything to the contrary in this Section 3(d), the Board may not delegate to an
Officer authority to determine the Fair Market Value of the Common Stock pursuant to Section
2(s)(ii) above.

     (e) Effect of Board’s Decision. All determinations, interpretations and constructions made by
the Board in good faith shall not be subject to review by any person and shall be final, binding
and conclusive on all persons.

4. Shares Subject to the Plan.

     (a) Share Reserve. Subject to the provisions of Section 10(a) relating to Capitalization
Adjustments, the number of shares of Common Stock that may be issued pursuant to Stock Awards shall
not exceed, in the aggregate, two million nine hundred ninety-two thousand two hundred eighty-seven (2,992,287) shares of Common Stock; provided, however,
that such share reserve shall be increased from time to time by the number of shares of Common
Stock that (i) are issuable pursuant to stock awards outstanding

10.

 

under the Company’s Prior Plans as of the effective date of the Plan (as set forth in Section
13), and (ii) but for the amendment and restatement of the Prior Plans as of the effective date of
this Plan, would otherwise have reverted to the share reserves of the Prior Plans. In addition,
the number of shares of Common Stock available for issuance under the Plan shall automatically
increase on January 1st of each year commencing in 2007 and ending on (and including) January 1,
2015, in an amount equal to the lesser of (i) two percent (2.0%) of the total number
of shares of Common Stock outstanding on December 31st of the preceding calendar year, or (ii) two
million nine hundred ninety-two thousand two hundred eighty-seven (2,992,287) shares of Common Stock. Notwithstanding the foregoing, the Board may act prior
to the first day of any calendar year, to provide that there shall be no increase in the share
reserve for such calendar year or that the increase in the share reserve for such calendar year
shall be a lesser number of shares of Common Stock than would otherwise occur pursuant to the
preceding sentence.

     (b) Reversion of Shares to the Share Reserve. If any Stock Award shall for any reason expire
or otherwise terminate, in whole or in part, without having been exercised in full, if any shares
of Common Stock issued to a Participant pursuant to a Stock Award are forfeited to or repurchased
by the Company, including, but not limited to, any repurchase or forfeiture caused by the failure
to meet a contingency or condition required for the vesting of such shares, or if any shares of
Common Stock are cancelled in accordance with the cancellation and regrant provisions of Section
3(b)(v), then the shares of Common Stock not issued under such Stock Award, or forfeited to or
repurchased by the Company, shall revert to and again become available for issuance under the Plan.
If any shares subject to a Stock Award are not delivered to a Participant because such shares are
withheld for the payment of taxes or the Stock Award is exercised through a reduction of shares
subject to the Stock Award (i.e., “net exercised”), the number of shares that are not delivered to
the Participant shall remain available for issuance under the Plan. If the exercise price of any
Stock Award is satisfied by tendering shares of Common Stock held by the Participant (either by
actual delivery or attestation), then the number of shares so tendered shall remain available for
issuance under the Plan. Notwithstanding anything to the contrary in this Section 4(b), subject to
the provisions of Section 10(a) relating to Capitalization Adjustments the aggregate maximum number
of shares of Common Stock that may be issued pursuant to the exercise of Incentive Stock Options
shall be two million nine hundred ninety-two thousand two hundred eighty-seven (2,992,287) shares of Common Stock plus the amount of any increase in the
number of shares that may be available for issuance pursuant to Stock Awards pursuant to Section
4(a).

     (c) Source of Shares. The stock issuable under the Plan shall be shares of authorized but
unissued or reacquired Common Stock, including shares repurchased by the Company on the open
market.

5. Eligibility.

     (a) Eligibility for Specific Stock Awards. Incentive Stock Options may be granted only to
Employees. Stock Awards other than Incentive Stock Options may be granted to Employees, Directors
and Consultants.

     (b) Ten Percent Stockholders. A Ten Percent Stockholder shall not be granted an Incentive
Stock Option unless the exercise price of such Option is at least one hundred ten

11.

 

percent (110%) of the Fair Market Value of the Common Stock on the date of grant and the
Option is not exercisable after the expiration of five (5) years from the date of grant.

     (c) Section 162(m) Limitation on Annual Grants. Subject to the provisions of Section 10(a)
relating to Capitalization Adjustments, at such time as the Company may be subject to the
applicable provisions of Section 162(m) of the Code, no Employee shall be eligible to be granted
Stock Awards whose value is determined by reference to an increase over an exercise or strike price
of at least one hundred percent (100%) of the Fair Market Value of the Common Stock on the date the
Stock Award is granted covering more than five hundred thousand (500,000) shares of Common Stock
during any calendar year.

     (d) Consultants. A Consultant shall not be eligible for the grant of a Stock Award if, at the
time of grant, a Form S-8 Registration Statement under the Securities Act (“Form S-8”) is not
available to register either the offer or the sale of the Company’s securities to such Consultant
because of the nature of the services that the Consultant is providing to the Company, because the
Consultant is not a natural person, or because of any other rule governing the use of Form S-8.

6. Option Provisions.

     Each Option shall be in such form and shall contain such terms and conditions as the Board
shall deem appropriate. All Options shall be separately designated Incentive Stock Options or
Nonstatutory Stock Options at the time of grant, and, if certificates are issued, a separate
certificate or certificates shall be issued for shares of Common Stock purchased on exercise of
each type of Option. The provisions of separate Options need not be identical; provided, however,
that each Option Agreement shall include (through incorporation of provisions hereof by reference
in the Option or otherwise) the substance of each of the following provisions:

     (a) Term. The Board shall determine the term of an Option; provided, however, that subject
to the provisions of Section 5(b) regarding Ten Percent Stockholders, no Incentive Stock Option
shall be exercisable after the expiration of ten (10) years from the date of grant.

     (b) Exercise Price of an Incentive Stock Option. Subject to the provisions of Section 5(b)
regarding Ten Percent Stockholders, the exercise price of each Incentive Stock Option shall be not
less than one hundred percent (100%) of the Fair Market Value of the Common Stock subject to the
Option on the date the Option is granted. Notwithstanding the foregoing, an Incentive Stock Option
may be granted with an exercise price lower than that set forth in the preceding sentence if such
Option is granted pursuant to an assumption or substitution for another option in a manner
consistent with the provisions of Section 424(a) of the Code.

     (c) Exercise Price of a Nonstatutory Stock Option. The exercise price of each Nonstatutory
Stock Option shall be not less than one hundred percent (100%) of the Fair Market Value of the
Common Stock subject to the Option on the date the Option is granted. Notwithstanding the
foregoing, a Nonstatutory Stock Option may be granted with an exercise price lower than that set
forth in the preceding sentence if such Option is granted pursuant to an

12.

 

assumption or substitution for another option in a manner consistent with the provisions of
Section 424(a) of the Code.

     (d) Consideration. The purchase price of Common Stock acquired pursuant to the exercise of an
Option shall be paid, to the extent permitted by applicable law and as determined by the Board in
its sole discretion, by any combination of the methods of payment set forth below. The Board shall
have the authority to grant Options that do not permit all of the following methods of payment (or
otherwise restrict the ability to use certain methods) and to grant Options that require the
consent of the Company to utilize a particular method of payment. The methods of payment permitted
by this Section 6(d) are:

          (i) by cash or check;

          (ii) pursuant to a program developed under Regulation T as promulgated by the Federal Reserve
Board that, prior to the issuance of Common Stock, results in either the receipt of cash (or check)
by the Company or the receipt of irrevocable instructions to pay the aggregate exercise price to
the Company from the sales proceeds; provided, however, that such program is not in violation of
the prohibition on the extension of credit to the Company’s executive officers and Directors under
Section 402 of the Sarbanes-Oxley Act of 2002, in the opinion of counsel acceptable to the Company;

          (iii) by delivery to the Company (either by actual delivery or attestation) of shares of
Common Stock;

          (iv) by a “net exercise” arrangement pursuant to which the Company will reduce the number of
shares of Common Stock issued upon exercise by the largest whole number of shares with a Fair
Market Value that does not exceed the aggregate exercise price; provided, however, the Company
shall accept a cash or other payment from the Participant to the extent of any remaining balance of
the aggregate exercise price not satisfied by such reduction in the number of whole shares to be
issued; provided, however, shares of Common Stock will no longer be outstanding under an Option and
will not be exercisable thereafter to the extent that (i) shares are used to pay the exercise price
pursuant to the “net exercise,” (ii) shares are delivered to the Participant as a result of such
exercise, and (iii) shares are withheld to satisfy tax withholding obligations; or

          (v) in any other form of legal consideration that may be acceptable to the Board.

     (e) Transferability of Options. The Board may, in its sole discretion, impose such
limitations on the transferability of Options as the Board shall determine. In the absence of such
a determination by the Board to the contrary, the following restrictions on the transferability of
Options shall apply:

          (i) Restrictions on Transfer. An Option shall not be transferable except by will or by the
laws of descent and distribution and shall be exercisable during the lifetime of the Optionholder
only by the Optionholder.

13.

 

          (ii) Domestic Relations Orders. Notwithstanding the foregoing, an Option may be transferred
pursuant to a domestic relations order.

          (iii) Beneficiary Designation. Notwithstanding the foregoing, the Optionholder may, by
delivering written notice to the Company, in a form provided by or otherwise satisfactory to the
Company, designate a third party who, in the event of the death of the Optionholder, shall
thereafter be entitled to exercise the Option.

     (f) Vesting Generally. The total number of shares of Common Stock subject to an Option may
vest and therefore become exercisable in periodic installments that may or may not be equal. The
Option may be subject to such other terms and conditions on the time or times when it may or may
not be exercised (which may be based on performance or other criteria) as the Board may deem
appropriate. The vesting provisions of individual Options may vary. The provisions of this
Section 6(f) are subject to any Option provisions governing the minimum number of shares of Common
Stock as to which an Option may be exercised.

     (g) Termination of Continuous Service. In the event that an Optionholder’s Continuous Service
terminates (other than upon the Optionholder’s death or Disability), the Optionholder may exercise
his or her Option (to the extent that the Optionholder was entitled to exercise such Option as of
the date of termination of Continuous Service) but only within such period of time ending on the
earlier of (i) the date three (3) months following the termination of the Optionholder’s Continuous
Service (or such longer or shorter period specified in the Option Agreement), or (ii) the
expiration of the term of the Option as set forth in the Option Agreement. If, after termination
of Continuous Service, the Optionholder does not exercise his or her Option within the time
specified herein or in the Option Agreement (as applicable), the Option shall terminate.

     (h) Extension of Termination Date. An Optionholder’s Option Agreement may provide that if the
exercise of the Option following the termination of the Optionholder’s Continuous Service (other
than upon the Optionholder’s death or Disability or upon a Change in Control) would be prohibited
at any time solely because the issuance of shares of Common Stock would violate the registration
requirements under the Securities Act, then the Option shall terminate on the earlier of (i) the
expiration of a period of three (3) months after the termination of the Optionholder’s Continuous
Service during which the exercise of the Option would not be in violation of such registration
requirements, or (ii) the expiration of the term of the Option as set forth in the Option
Agreement.

     (i) Disability of Optionholder. In the event that an Optionholder’s Continuous Service
terminates as a result of the Optionholder’s Disability, the Optionholder may exercise his or her
Option (to the extent that the Optionholder was entitled to exercise such Option as of the date of
termination of Continuous Service), but only within such period of time ending on the earlier of
(i) the date twelve (12) months following such termination of Continuous Service (or such longer or
shorter period specified in the Option Agreement), or (ii) the expiration of the term of the Option
as set forth in the Option Agreement. If, after termination of Continuous Service, the
Optionholder does not exercise his or her Option within the time specified herein or in the Option
Agreement (as applicable), the Option shall terminate.

14.

 

     (j) Death of Optionholder. In the event that (i) an Optionholder’s Continuous Service
terminates as a result of the Optionholder’s death, or (ii) the Optionholder dies within the period
(if any) specified in the Option Agreement after the termination of the Optionholder’s Continuous
Service for a reason other than death, then the Option may be exercised (to the extent the
Optionholder was entitled to exercise such Option as of the date of death) by the Optionholder’s
estate, by a person who acquired the right to exercise the Option by bequest or inheritance or by a
person designated to exercise the option upon the Optionholder’s death, but only within the period
ending on the earlier of (i) the date eighteen (18) months following the date of death (or such
longer or shorter period specified in the Option Agreement), or (ii) the expiration of the term of
such Option as set forth in the Option Agreement. If, after the Optionholder’s death, the Option
is not exercised within the time specified herein or in the Option Agreement (as applicable), the
Option shall terminate.

     (k) Early Exercise. The Option may include a provision whereby the Optionholder may elect at
any time before the Optionholder’s Continuous Service terminates to exercise the Option as to any
part or all of the shares of Common Stock subject to the Option prior to the full vesting of the
Option. Any unvested shares of Common Stock so purchased may be subject to a repurchase option in
favor of the Company or to any other restriction the Board determines to be appropriate. The
Company shall not be required to exercise its repurchase option until at least six (6) months (or
such longer or shorter period of time necessary to avoid a charge to earnings for financial
accounting purposes) have elapsed following exercise of the Option unless the Board otherwise
specifically provides in the Option.

7. Provisions of Stock Awards other than Options.

     (a) Stock Purchase Awards. Each Stock Purchase Award Agreement shall be in such form and
shall contain such terms and conditions as the Board shall deem appropriate. At the Board’s
election, shares of Common Stock may be (i) held in book entry form subject to the Company’s
instructions until any restrictions relating to the Stock Purchase Award lapse; or (ii) evidenced
by a certificate, which certificate shall be held in such form and manner as determined by the
Board. The terms and conditions of Stock Purchase Award Agreements may change from time to time,
and the terms and conditions of separate Stock Purchase Award Agreements need not be identical;
provided, however, that each Stock Purchase Award Agreement shall include (through incorporation of
the provisions hereof by reference in the agreement or otherwise) the substance of each of the
following provisions:

          (i) Purchase Price. At the time of the grant of a Stock Purchase Award, the Board will
determine the price to be paid by the Participant for each share subject to the Stock Purchase
Award. To the extent required by applicable law, the price to be paid by the Participant for each
share of the Stock Purchase Award will not be less than the par value of a share of Common Stock.

          (ii) Consideration. At the time of the grant of a Stock Purchase Award, the Board will
determine the consideration permissible for the payment of the purchase price of the Stock Purchase
Award. The purchase price of Common Stock acquired pursuant to the Stock Purchase Award shall be
paid either: (i) in cash or by check at the time of purchase, (ii) at the discretion of the Board,
according to a deferred payment or other similar arrangement with the

15.

 

Participant, (iii) by past or future services rendered to the Company or an Affiliate, or (iv)
in any other form of legal consideration that may be acceptable to the Board in its sole discretion
and permissible under applicable law.

          (iii) Vesting. Shares of Common Stock acquired under a Stock Purchase Award may be subject to
a share repurchase right or option in favor of the Company in accordance with a vesting schedule to
be determined by the Board.

          (iv) Termination of Participant’s Continuous Service. In the event that a Participant’s
Continuous Service terminates, the Company shall have the right, but not the obligation, to
repurchase or otherwise reacquire, any or all of the shares of Common Stock held by the Participant
that have not vested as of the date of termination under the terms of the Stock Purchase Award
Agreement. At the Board’s election, the price paid for all shares of Common Stock so repurchased
or reacquired by the Company may be at the lesser of: (i) the Fair Market Value on the relevant
date, or (ii) the Participant’s original cost for such shares. The Company shall not be required
to exercise its repurchase or reacquisition option until at least six (6) months (or such longer or
shorter period of time necessary to avoid a charge to earnings for financial accounting purposes)
have elapsed following the Participant’s purchase of the shares of stock acquired pursuant to the
Stock Purchase Award unless otherwise determined by the Board or provided in the Stock Purchase
Award Agreement.

          (v) Transferability. Rights to purchase or receive shares of Common Stock granted under a
Stock Purchase Award shall be transferable by the Participant only upon such terms and conditions
as are set forth in the Stock Purchase Award Agreement, as the Board shall determine in its sole
discretion, and so long as Common Stock awarded under the Stock Purchase Award remains subject to
the terms of the Stock Purchase Award Agreement.

     (b) Stock Bonus Awards. Each Stock Bonus Award Agreement shall be in such form and shall
contain such terms and conditions as the Board shall deem appropriate. At the Board’s election,
shares of Common Stock may be (i) held in book entry form subject to the Company’s instructions
until any restrictions relating to the Stock Bonus Award lapse; or (ii) evidenced by a certificate,
which certificate shall be held in such form and manner as determined by the Board. The terms and
conditions of Stock Bonus Award Agreements may change from time to time, and the terms and
conditions of separate Stock Bonus Award Agreements need not be identical, provided, however, that
each Stock Bonus Award Agreement shall include (through incorporation of provisions hereof by
reference in the agreement or otherwise) the substance of each of the following provisions:

          (i) Consideration. A Stock Bonus Award may be awarded in consideration for (i) past or future
services rendered to the Company or an Affiliate, or (ii) any other form of legal consideration
that may be acceptable to the Board in its sole discretion and permissible under applicable law.

          (ii) Vesting. Shares of Common Stock awarded under the Stock Bonus Award Agreement may be
subject to forfeiture to the Company in accordance with a vesting schedule to be determined by the
Board.

16.

 

          (iii) Termination of Participant’s Continuous Service. In the event a Participant’s
Continuous Service terminates, the Company may receive via a forfeiture condition, any or all of
the shares of Common Stock held by the Participant which have not vested as of the date of
termination of Continuous Service under the terms of the Stock Bonus Award Agreement.

          (iv) Transferability. Rights to acquire shares of Common Stock under the Stock Bonus Award
Agreement shall be transferable by the Participant only upon such terms and conditions as are set
forth in the Stock Bonus Award Agreement, as the Board shall determine in its sole discretion, so
long as Common Stock awarded under the Stock Bonus Award Agreement remains subject to the terms of
the Stock Bonus Award Agreement.

     (c) Stock Unit Awards. Each Stock Unit Award Agreement shall be in such form and shall
contain such terms and conditions as the Board shall deem appropriate. The terms and conditions of
Stock Unit Award Agreements may change from time to time, and the terms and conditions of separate
Stock Unit Award Agreements need not be identical, provided, however, that each Stock Unit Award
Agreement shall include (through incorporation of the provisions hereof by reference in the
agreement or otherwise) the substance of each of the following provisions:

          (i) Consideration. At the time of grant of a Stock Unit Award, the Board will determine the
consideration, if any, to be paid by the Participant upon delivery of each share of Common Stock
subject to the Stock Unit Award. The consideration to be paid (if any) by the Participant for each
share of Common Stock subject to a Stock Unit Award may be paid in any form of legal consideration
that may be acceptable to the Board in its sole discretion and permissible under applicable law.

          (ii) Vesting. At the time of the grant of a Stock Unit Award, the Board may impose such
restrictions or conditions to the vesting of the Stock Unit Award as it, in its sole discretion,
deems appropriate.

          (iii) Payment. A Stock Unit Award may be settled by the delivery of shares of Common Stock,
their cash equivalent, any combination thereof or in any other form of consideration, as determined
by the Board and contained in the Stock Unit Award Agreement.

          (iv) Additional Restrictions. At the time of the grant of a Stock Unit Award, the Board, as
it deems appropriate, may impose such restrictions or conditions that delay the delivery of the
shares of Common Stock (or their cash equivalent) subject to a Stock Unit Award after the vesting
of such Stock Unit Award.

          (v) Dividend Equivalents. Dividend equivalents may be credited in respect of shares of Common
Stock covered by a Stock Unit Award, as determined by the Board and contained in the Stock Unit
Award Agreement. At the sole discretion of the Board, such dividend equivalents may be converted
into additional shares of Common Stock covered by the Stock Unit Award in such manner as determined
by the Board. Any additional shares covered by the Stock Unit Award credited by reason of such
dividend equivalents will be subject to all the terms and conditions of the underlying Stock Unit
Award Agreement to which they relate.

17.

 

          (vi) Termination of Participant’s Continuous Service. Except as otherwise provided in the
applicable Stock Unit Award Agreement, such portion of the Stock Unit Award that has not vested
will be forfeited upon the Participant’s termination of Continuous Service.

     (d) Stock Appreciation Rights. Each Stock Appreciation Right Agreement shall be in such form
and shall contain such terms and conditions as the Board shall deem appropriate. The terms and
conditions of Stock Appreciation Right Agreements may change from time to time, and the terms and
conditions of separate Stock Appreciation Right Agreements need not be identical; provided,
however, that each Stock Appreciation Right Agreement shall include (through incorporation of the
provisions hereof by reference in the agreement or otherwise) the substance of each of the
following provisions:

          (i) Strike Price and Calculation of Appreciation. Each Stock Appreciation Right will be
denominated in shares of Common Stock equivalents. The appreciation distribution payable on the
exercise of a Stock Appreciation Right will be not greater than an amount equal to the excess of
(i) the aggregate Fair Market Value (on the date of the exercise of the Stock Appreciation Right)
of a number of shares of Common Stock equal to the number of share of Common Stock equivalents in
which the Participant is vested under such Stock Appreciation Right, and with respect to which the
Participant is exercising the Stock Appreciation Right on such date, over (ii) an amount (the
strike price) that will be determined by the Board at the time of grant of the Stock Appreciation
Right.

          (ii) Vesting. At the time of the grant of a Stock Appreciation Right, the Board may impose
such restrictions or conditions to the vesting of such Stock Appreciation Right as it, in its sole
discretion, deems appropriate.

          (iii) Exercise. To exercise any outstanding Stock Appreciation Right, the Participant must
provide written notice of exercise to the Company in compliance with the provisions of the Stock
Appreciation Right Agreement evidencing such Stock Appreciation Right.

          (iv) Payment. The appreciation distribution in respect to a Stock Appreciation Right may be
paid by the delivery of shares of Common Stock, in cash, any combination thereof or in any other
form of consideration, as determined by the Board and contained in the Stock Appreciation Right
Agreement evidencing such Stock Appreciation Right.

          (v) Termination of Continuous Service. In the event that a Participant’s Continuous Service
terminates, the Participant may exercise his or her Stock Appreciation Right (to the extent that
the Participant was entitled to exercise such Stock Appreciation Right as of the date of
termination) but only within such period of time ending on the earlier of (i) the date three (3)
months following the termination of the Participant’s Continuous Service (or such longer or shorter
period specified in the Stock Appreciation Right Agreement), or (ii) the expiration of the term of
the Stock Appreciation Right as set forth in the Stock Appreciation Right Agreement. If, after
termination, the Participant does not exercise his or her Stock Appreciation Right within the time
specified herein or in the Stock Appreciation Right Agreement (as applicable), the Stock
Appreciation Right shall terminate.

18.

 

     (e) Performance Stock Awards. A Performance Stock Award is any Stock Award that may be
granted, may vest, or may be exercised based upon service conditions, upon the attainment during a
Performance Period of certain Performance Goals, or both. The length of any Performance Period,
the Performance Goals to be achieved during the Performance Period, and the measure of whether and
to what degree such Performance Goals have been attained shall be conclusively determined by the
Board in its sole discretion. The maximum benefit to be received by any individual in any calendar
year attributable to Performance Stock Awards shall not exceed the value of five hundred thousand
(500,000) shares of Common Stock.

     (f) Other Stock Awards. Other forms of Stock Awards valued in whole or in part by reference
to, or otherwise based on, Common Stock may be granted either alone or in addition to Stock Awards
provided for under Section 6 and the preceding provisions of this Section 7. Subject to the
provisions of the Plan, the Board shall have sole and complete authority to determine the persons
to whom and the time or times at which such Other Stock Awards will be granted, the number of
shares of Common Stock (or the cash equivalent thereof) to be granted pursuant to such Other Stock
Awards and all other terms and conditions of such Other Stock Awards.

8. Covenants of the Company.

     (a) Availability of Shares. During the terms of the Stock Awards, the Company shall keep
available at all times the number of shares of Common Stock required to satisfy such Stock Awards.

     (b) Securities Law Compliance. The Company shall seek to obtain from each regulatory
commission or agency having jurisdiction over the Plan such authority as may be required to grant
Stock Awards and to issue and sell shares of Common Stock upon exercise of the Stock Awards;
provided, however, that this undertaking shall not require the Company to register under the
Securities Act the Plan, any Stock Award or any Common Stock issued or issuable pursuant to any
such Stock Award. If, after reasonable efforts, the Company is unable to obtain from any such
regulatory commission or agency the authority that counsel for the Company deems necessary for the
lawful issuance and sale of Common Stock under the Plan, the Company shall be relieved from any
liability for failure to issue and sell Common Stock upon exercise of such Stock Awards unless and
until such authority is obtained.

9. Miscellaneous.

     (a) Use of Proceeds. Proceeds from the sale of shares of Common Stock pursuant to Stock
Awards shall constitute general funds of the Company.

     (b) Stockholder Rights. No Participant shall be deemed to be the holder of, or to have any of
the rights of a holder with respect to, any shares of Common Stock subject to such Stock Award
unless and until such Participant has satisfied all requirements for exercise of the Stock Award
pursuant to its terms.

     (c) No Employment or Other Service Rights. Nothing in the Plan, any Stock Award Agreement or
other instrument executed thereunder or any Stock Award granted pursuant thereto shall confer upon
any Participant any right to continue to serve the Company or an

19.

 

Affiliate in the capacity in effect at the time the Stock Award was granted or shall affect
the right of the Company or an Affiliate to terminate (i) the employment of an Employee with or
without notice and with or without cause, (ii) the service of a Consultant pursuant to the terms of
such Consultant’s agreement with the Company or an Affiliate, or (iii) the service of a Director
pursuant to the Bylaws of the Company or an Affiliate, and any applicable provisions of the
corporate law of the state in which the Company or the Affiliate is incorporated, as the case may
be.

     (d) Incentive Stock Option $100,000 Limitation. To the extent that the aggregate Fair Market
Value (determined at the time of grant) of Common Stock with respect to which Incentive Stock
Options are exercisable for the first time by any Optionholder during any calendar year (under all
plans of the Company and any Affiliates) exceeds one hundred thousand dollars ($100,000), the
Options or portions thereof that exceed such limit (according to the order in which they were
granted) shall be treated as Nonstatutory Stock Options, notwithstanding any contrary provision of
the applicable Option Agreement(s).

     (e) Investment Assurances. The Company may require a Participant, as a condition of
exercising or acquiring Common Stock under any Stock Award, (i) to give written assurances
satisfactory to the Company as to the Participant’s knowledge and experience in financial and
business matters and/or to employ a purchaser representative reasonably satisfactory to the Company
who is knowledgeable and experienced in financial and business matters and that he or she is
capable of evaluating, alone or together with the purchaser representative, the merits and risks of
exercising the Stock Award; and (ii) to give written assurances satisfactory to the Company stating
that the Participant is acquiring Common Stock subject to the Stock Award for the Participant’s own
account and not with any present intention of selling or otherwise distributing the Common Stock.
The foregoing requirements, and any assurances given pursuant to such requirements, shall be
inoperative if (i) the issuance of the shares upon the exercise or acquisition of Common Stock
under the Stock Award has been registered under a then currently effective registration statement
under the Securities Act, or (ii) as to any particular requirement, a determination is made by
counsel for the Company that such requirement need not be met in the circumstances under the then
applicable securities laws. The Company may, upon advice of counsel to the Company, place legends
on stock certificates issued under the Plan as such counsel deems necessary or appropriate in order
to comply with applicable securities laws, including, but not limited to, legends restricting the
transfer of the Common Stock.

     (f) Withholding Obligations. To the extent provided by the terms of a Stock Award Agreement,
the Company may, in its sole discretion, satisfy any federal, state or local tax withholding
obligation relating to a Stock Award by any of the following means (in addition to the Company’s
right to withhold from any compensation paid to the Participant by the Company) or by a combination
of such means: (i) causing the Participant to tender a cash payment; (ii) withholding shares of
Common Stock from the shares of Common Stock issued or otherwise issuable to the Participant in
connection with the Stock Award; provided, however, that no shares of Common Stock are withheld
with a value exceeding the minimum amount of tax required to be withheld by law (or such lower
amount as may be necessary to avoid variable award accounting); or (iii) by such other method as
may be set forth in the Stock Award Agreement.

20.

 

     (g) Electronic Delivery. Any reference herein to a “written” agreement or document shall
include any agreement or document delivered electronically or posted on the Company’s intranet.

10. Adjustments upon Changes in Common Stock; Corporate Transactions.

     (a) Capitalization Adjustments. If any change is made in, or other events occur with respect
to, the Common Stock subject to the Plan or subject to any Stock Award after the effective date of
the Plan set forth in Section 13 without the receipt of consideration by the Company (through
merger, consolidation, reorganization, recapitalization, reincorporation, stock dividend, dividend
in property other than cash, stock split, liquidating dividend, combination of shares, exchange of
shares, change in corporate structure or other transaction not involving the receipt of
consideration by the Company (each a “Capitalization Adjustment”)), the Board shall appropriately
adjust: (i) the class(es) and maximum number of securities subject to the Plan pursuant to Section
4(a), (ii) the class(es) and maximum number of securities by which the share reserve is to increase
automatically each year pursuant to Section 4(a), (iii) the class(es) and number of securities
subject to each outstanding stock award under the Prior Plans that are added from time to time to
the share reserve under the Plan pursuant to Section 4(a), (iv) the class(es) and maximum number of
securities that may be issued pursuant to the exercise of Incentive Stock Options pursuant to
Section 4(b), (v) the class(es) and maximum number of securities that may be awarded to any person
pursuant to Sections 5(c) and 7(e), and (vi) the class(es) and number of securities and price per
share of stock subject to outstanding Stock Awards. The Board shall make such adjustments, and its
determination shall be final, binding and conclusive. (Notwithstanding the foregoing, the
conversion of any convertible securities of the Company shall not be treated as a transaction
“without receipt of consideration” by the Company.)

     (b) Dissolution or Liquidation. In the event of a dissolution or liquidation of the Company,
all outstanding Stock Awards (other than Stock Awards consisting of vested and outstanding shares
of Common Stock not subject to the Company’s right of repurchase) shall terminate immediately prior
to the completion of such dissolution or liquidation, and the shares of Common Stock subject to the
Company’s repurchase option may be repurchased by the Company notwithstanding the fact that the
holder of such Stock Award is providing Continuous Service, provided, however, that the Board may,
in its sole discretion, cause some or all Stock Awards to become fully vested, exercisable and/or
no longer subject to repurchase or forfeiture (to the extent such Stock Awards have not previously
expired or terminated) before the dissolution or liquidation is completed but contingent on its
completion.

     (c) Corporate Transaction. The following provisions shall apply to Stock Awards in the event
of a Corporate Transaction unless otherwise provided in a written agreement between the Company or
any Affiliate and the holder of the Stock Award:

          (i) Stock Awards May Be Assumed. In the event of a Corporate Transaction, any surviving
corporation or acquiring corporation (or the surviving or acquiring corporation’s parent company)
may assume or continue any or all Stock Awards outstanding under the Plan or may substitute similar
stock awards for Stock Awards outstanding under the Plan (including but not limited to, awards to
acquire the same consideration paid to the stockholders of the Company pursuant to the Corporate
Transaction), and any reacquisition or

21.

 

repurchase rights held by the Company in respect of Common Stock issued pursuant to Stock
Awards may be assigned by the Company to the successor of the Company (or the successor’s parent
company, if any), in connection with such Corporate Transaction. A surviving corporation or
acquiring corporation may choose to assume or continue only a portion of a Stock Award or
substitute a similar stock award for only a portion of a Stock Award. The terms of any assumption,
continuation or substitution shall be set by the Board in accordance with the provisions of Section
3(b).

          (ii) Stock Awards Held by Current Participants. In the event of a Corporate Transaction in
which the surviving corporation or acquiring corporation (or its parent company) does not assume or
continue such outstanding Stock Awards or substitute similar stock awards for such outstanding
Stock Awards, then with respect to Stock Awards that have not been assumed, continued or
substituted and that are held by Participants whose Continuous Service has not terminated prior to
the effective time of the Corporate Transaction (referred to as the “Current Participants”), the
vesting of such Stock Awards (and, if applicable, the time at which such Stock Awards may be
exercised) shall (contingent upon the effectiveness of the Corporate Transaction) be accelerated in
full to a date prior to the effective time of such Corporate Transaction as the Board shall
determine (or, if the Board shall not determine such a date, to the date that is five (5) days
prior to the effective time of the Corporate Transaction), and such Stock Awards shall terminate if
not exercised (if applicable) at or prior to the effective time of the Corporate Transaction, and
any reacquisition or repurchase rights held by the Company with respect to such Stock Awards shall
lapse (contingent upon the effectiveness of the Corporate Transaction). No vested Stock Unit Award
shall terminate pursuant to this Section 10(c)(ii) without being settled by delivery of shares of
Common Stock, their cash equivalent, any combination thereof, or in any other form of
consideration, as determined by the Board, prior to the effective time of the Corporate
Transaction.

          (iii) Stock Awards Held by Former Participants. In the event of a Corporate Transaction in
which the surviving corporation or acquiring corporation (or its parent company) does not assume or
continue such outstanding Stock Awards or substitute similar stock awards for such outstanding
Stock Awards, then with respect to Stock Awards that have not been assumed, continued or
substituted and that are held by persons other than Current Participants, the vesting of such Stock
Awards (and, if applicable, the time at which such Stock Award may be exercised) shall not be
accelerated and such Stock Awards (other than a Stock Award consisting of vested and outstanding
shares of Common Stock not subject to the Company’s right of repurchase) shall terminate if not
exercised (if applicable) prior to the effective time of the Corporate Transaction; provided,
however, that any reacquisition or repurchase rights held by the Company with respect to such Stock
Awards shall not terminate and may continue to be exercised notwithstanding the Corporate
Transaction. No vested Stock Unit Award shall terminate pursuant to this Section 10(c)(iii)
without being settled by delivery of shares of Common Stock, their cash equivalent, any combination
thereof, or in any other form of consideration, as determined by the Board, prior to the effective
time of the Corporate Transaction.

          (iv) Payment for Stock Awards in Lieu of Exercise. Notwithstanding the foregoing, in the
event a Stock Award will terminate if not exercised prior to the effective time of a Corporate
Transaction, the Board may provide, in its sole discretion, that the holder of such

22.

 

Stock Award may not exercise such Stock Award but will receive a payment, in such form as may
be determined by the Board, equal in value to the excess, if any, of (i) the value of the property
the holder of the Stock Award would have received upon the exercise of the Stock Award, over (ii)
any exercise price payable by such holder in connection with such exercise.

     (d) Change in Control. A Stock Award may be subject to additional acceleration of vesting and
exercisability upon or after a Change in Control as may be provided in the Stock Award Agreement
for such Stock Award or as may be provided in any other written agreement between the Company or
any Affiliate and the Participant. A Stock Award may vest as to all or any portion of the shares
subject to the Stock Award (i) immediately upon the occurrence of a Change in Control, whether or
not such Stock Award is assumed, continued, or substituted by a surviving or acquiring entity in
the Change in Control, or (ii) in the event a Participant’s Continuous Service is terminated,
actually or constructively, within a designated period following the occurrence of a Change in
Control. In the absence of such provisions, no such acceleration shall occur.

11. Amendment of the Plan and Stock Awards.

     (a) Amendment of Plan. Subject to the limitations, if any, of applicable law, the Board at
any time, and from time to time, may amend the Plan. However, except as provided in Section 10(a)
relating to Capitalization Adjustments, no amendment shall be effective unless approved by the
stockholders of the Company to the extent stockholder approval is necessary to satisfy applicable
law.

     (b) Stockholder Approval. The Board, in its sole discretion, may submit any other amendment
to the Plan for stockholder approval, including, but not limited to, amendments to the Plan
intended to satisfy the requirements of Section 162(m) of the Code and the regulations thereunder
regarding the exclusion of performance-based compensation from the limit on corporate deductibility
of compensation paid to Covered Employees.

     (c) Contemplated Amendments. It is expressly contemplated that the Board may amend the Plan
in any respect the Board deems necessary or advisable to provide eligible Employees with the
maximum benefits provided or to be provided under the provisions of the Code and the regulations
promulgated thereunder relating to Incentive Stock Options and/or to bring the Plan and/or
Incentive Stock Options granted under it into compliance therewith.

     (d) No Impairment of Rights. Rights under any Stock Award granted before amendment of the
Plan shall not be impaired by any amendment of the Plan unless (i) the Company requests the consent
of the affected Participant, and (ii) such Participant consents in writing.

     (e) Amendment of Stock Awards. The Board, at any time and from time to time, may amend the
terms of any one or more Stock Awards, including, but not limited to, amendments to provide terms
more favorable than previously provided in the Stock Award Agreement, subject to any specified
limits in the Plan that are not subject to Board discretion; provided, however, that the rights
under any Stock Award shall not be impaired by any such

23.

 

amendment unless (i) the Company requests the consent of the affected Participant, and (ii)
such Participant consents in writing.

12. Termination or Suspension of the Plan.

     (a) Plan Term. The Board may suspend or terminate the Plan at any time. Unless sooner
terminated, the Plan shall terminate on the day before the tenth (10th) anniversary of the earlier
of (i) the date the amended and restated Plan is adopted by the Board, or (ii) the date the Plan is approved by the
stockholders of the Company. No Stock Awards may be granted under the Plan while the Plan is
suspended or after it is terminated.

     (b) No Impairment of Rights. Suspension or termination of the Plan shall not impair rights
and obligations under any Stock Award granted while the Plan is in effect except with the written
consent of the affected Participant.

13. Effective Date of Plan.

     The
2001 Equity Incentive Plan was effective as of July 20, 2001 and
the 2002 Equity Incentive Plan was effective as of May 30, 2002,
and the Prior Plans shall continue in their amended and restated form
as the 2005 Equity Incentive Plan, with such amendment and
restatement effective as of on the IPO Date, but no Stock Award shall be exercised (or, in
the case of a Stock Purchase Award, Stock Bonus Award, Stock Unit Award, or Other Stock Award shall
be granted) with respect to shares exceeding the number of shares
reserved for issuance under the Prior Plans prior to the effective
date of such amendment and restatement unless and until the Plan, as
Amended and Restated has
been approved by the stockholders of the Company, which
approval shall be within twelve (12) months before or after the
date the Amended and Restated Plan is adopted by the
Board. Stock Awards outstanding prior to the effective date of the
amendment and restatement set forth on the first page shall be
governed in full by provisions of the Prior Plan as in effect prior
to such amendment and restatement.

14. Choice of Law.

     The law of the State of Delaware shall govern all questions concerning the construction,
validity and interpretation of this Plan, without regard to that state’s conflict of laws rules.

24.exv10w18

 

Exhibit 10.18

FORM
OF PROMISSORY NOTE

 PROMISSORY NOTE SECURED BY DEED OF TRUST

(HOUSING
RELOCATION LOAN — I.R.C. Section 1.7872-5-(T))

	 	 	 
	June 27, 2003
	 	$1,200,000.00

Palo Alto, California

     1. FOR VALUE RECEIVED, the undersigned, Thomas B. King (“Borrower”), promises to pay to the
order of Alexza Molecular Delivery Corporation, a Delaware corporation (“Lender”), at 1001 East
Meadow Circle, Palo Alto, California 94303 (or at such other place as Lender may from time to time
designate by written notice to Borrower), in lawful money of the United States, the principal sum
of One Million Two Hundred Thousand Dollars ($1,200,000.00) (the “Principal”), without interest
until a Maturity Event and thereafter together with interest thereon at the rate of one and
forty-nine hundredths percent (1.49%) per annum.

     2. PAYMENT: The Principal and interest, if any, due pursuant to this Promissory Note
Secured by Deed of Trust (this “Note”) shall be paid as follows:

          2.1 Upon the occurrence of a Maturity Event (as defined herein), Borrower shall pay to
Lender all amounts due under this Note.

          2.2 Subject to the provisions of Section 4 herein, the principal amount of this Note shall be
due and payable as follows:

               (a) In the event that Borrower voluntarily terminates his
employment with Lender without “good reason,” the Principal shall be due and payable within thirty
(30) days of such termination date. As used herein, “good reason” shall mean the occurrence of any
of the following events without the Borrowers written consent:

                    (i) a substantial diminution in the nature, status or prestige of Borrower’s
responsibilities, title or reporting level pursuant to the employment offer letter from Lender to
Borrower dated May 25, 2003 (the “Offer Letter”), or the addition of responsibilities of a nature,
status or prestige inconsistent with the office of Chief Executive Officer and President of a
company such as Lender;

                    (ii) if and only if Borrower has relocated his home to the San Francisco Bay area,
California, the relocation of Lender’s executive Offices or principal business location to a point
more than fifty (50) miles from the Palo Alto,

A-1

 

 California area;

                    (iii) a material reduction by Lender of Borrower’s annual salary or annual bonus as
initially set forth in the Offer Letter or as the same may be increased from time to time;

                    (iv) any action by Lender (including the elimination of benefit plans without providing
substitutes thereof or the reduction of Borrower’s benefits thereunder) that would substantially
diminish the aggregate value of Borrower’s fringe benefits as they exist at such time;

                    (v) a failure by Lender to obtain from any successor,
before the succession takes place, an agreement to assume and perform all of the terms and
conditions of the Offer Letter; or

                    (vi) a material breach of the Offer Letter by Lender.

               (b) In the event that Lender terminates Borrower’s employment with Lender other than for
“cause,” the Principal shall be due and payable within thirty (30) days of such termination date,
provided, however, that if Borrower executes a waiver of all claims against Lender in a form
reasonably satisfactory to Lender, the Principal shall be due and payable on the date which is 12
months following the termination date. As used herein, “cause” shall mean the occurrence of any of
the following events:

                    (i) Borrower’s repeated failure to use reasonable efforts to satisfactorily perform his
employment duties after written notice, by the Board of Directors of Lender (the “Board”), of such
deficiency and an opportunity to cure within a reasonable period;

                    (ii) Borrower has committed an act that is, in the opinion of the Board, intended to or
does materially injure the business of Lender;

                    (iii) Borrower has refused or failed to follow lawful and
reasonable directions of the Board, after written notice by the Board and a reasonable period
thereafter to cure such performance;

                    (iv) Borrower has been convicted of a felony involving moral turpitude that is
likely, in the opinion of the Board, to inflict or has inflicted material injury on the
business of Lender:

                    (v) a determination by the Board that Borrower has
engaged in conduct constituting sexual harassment of any current or former employee of Lender: or

A-2

 

                    (vi) a determination by the Board that Borrower is, or has been, engaging or in any
manner participating in any activity which is directly competitive with, or intentionally
injurious to, Lender.

               (c) In the event that Lender offers its securities to the public, pursuant to a registration
statement filed with the Securities and Exchange Commission, in an initial public offering
(“IPO”), the Principal shall be due and payable on the earliest date of (i) three (3) years after
the date upon which Lender’s securities are first sold to the public in the IPO, or (ii) such date
as the Board, upon the advice of counsel, deems reasonably necessary to comply with “Applicable
Law.” As used herein, “Applicable Law” means any and all laws of whatever jurisdiction, within or
without the United States, including, but not limited to, the Sarbanes-Oxley Act of 2002, and the
rules of any stock exchange or quotation system on which Lender’s securities are then listed or
quoted, applicable to the taking or refraining from taking of any action under this Note.

               (d) In the event of a “Fundamental Corporate Transaction”, the Principal shall be due and
payable on the date which is 12 months following the effective date of the fundamental corporate
transaction. As used herein, a “Fundamental Corporate Transaction” shall mean:

                    (i) a merger or consolidation in which Lender is not the surviving corporation (other
than a merger or consolidation with a wholly-owned subsidiary, a reincorporation of Lender in a
different jurisdiction, or other transaction in which there is no substantial change in the
stockholders of Lender or their relative stock holdings);

                    (ii) a merger in which Lender is the surviving corporation
but after which the stockholders of Lender immediately prior to such merger (other than any
stockholder that merges, or which owns or controls another corporation that merges, with Lender
in such merger) cease to own their shares or other equity interest in Lender;

                    (iii) the sale of all or substantially all of the assets of Lender; or

                    (iv) the acquisition, sale, or transfer of more than 50% of the outstanding shares of
Lender by tender offer or similar transaction.

          2.3 Principal and interest shall be payable in lawful money of the United States.
Interest shall be calculated on the basis of a 360-day year consisting of twelve (12) months, each
of thirty (30) days, and shall compound annually. Each payment shall be applied first to accrued
interest, then to any other amounts (other than principal) payable hereunder as designated by
Lender, and then to reduce Principal.

A-3

 

          2.4 All payments made hereunder shall be made by Borrower free and clear of, and without
deduction for, any and all present and future taxes, levies, charges, deductions and withholdings.
Borrower shall pay upon demand any stamp or other taxes, levies or charges of any jurisdiction
with respect to the execution, delivery, performance and enforcement of this Note.

     3. SECURITY: This Note is secured by that certain Second Deed of Trust (the “Deed of Trust”)
of even date herewith made by Borrower, as trustor, to Thomas B. King and Beth A. King, as
trustee, for the benefit of Lender, as beneficiary, which shall be recorded in the Official
Records of the County of San Mateo, State of California, encumbering certain real property
commonly known as 91 James Avenue, Atherton, County of San Mateo, State of California (the
“Property”), described with particularity in the Deed of Trust, which Borrower intends to occupy
as his principal place of residence. The Deed of Trust provides, among other things, as follows:

“In the event the Property or any part thereof, or any interest therein is sold,
conveyed or alienated by the Trustor, whether voluntarily or involuntarily, except
as prohibited by law, all obligation secured by this instrument, irrespective of
the maturity dates express therein, at the option of the holder hereof and without
demand or notice, shall immediately become due and payable.”

     4. MATURITY EVENT: Upon the occurrence of a Maturity Event (as hereinafter defined), the
entire unpaid Principal balance shall become immediately due and payable without further demand or
notice to Borrower. To the extent permitted by law, any of the following events shall be a
“Maturity Event” under this Note and the Deed of Trust:

          (a) Borrower shall fail to pay any amount of the Principal on this Note when due and shall
fail to cure such non-payment within ten (10) days following written notice of such delinquency.

          (b) There shall occur a breach or default in the performance of any obligation of Borrower
contained in this Note, the Deed of Trust, the Employee Loan Agreement executed concurrently
herewith (the “Loan Documents”), or any other agreement now or hereafter entered into by Borrower,
on the one hand, and the Lender, on the other hand, with respect to the Property.

          (c) There shall occur a breach or default in the performance of any obligation of Borrower in
any other deed of trust or other security instrument (whether superior or subordinate in rights to
the Deed of Trust) now or hereafter encumbering the Property.

A-4

 

          (d) Borrower shall sell, convey, encumber, grant any lien upon, or otherwise alienate the
Property, or any part thereof, or any interest therein, or shall be divested of his title or any
interest therein in any manner or way, whether voluntarily or involuntarily, without the written
consent of the Lender being first had and obtained.

          (e) Borrower (i) admits in writing his inability to pay debts, (ii) makes an assignment for
the benefit of creditors, (iii) files a voluntary petition in bankruptcy, effect a plan or other
arrangement with creditors, liquidate his assets under arrangement with creditors, or liquidate
his assets under court supervision, (iv) has an involuntary petition in bankruptcy filed against
him that is not discharged within sixty (60) days after such petition is filed, or (v) applies for
or permit the appointment of a receiver or trustee or custodian for any of his property or assets
which shall not have been discharged within sixty (60) days after the date of appointment.

          (f) The Principal shall have become due and payable, upon the happening of certain
events, on such dates as are set forth in Section 2.2 herein.

          (g) Any representation or warranty of Borrower contained herein or in any certificate or
agreement entered into between Borrower for the benefit of Lender in connection herewith shall
prove to be false or misleading in any material respect.

          (h) The Deed of Trust is not recorded against the Property on or about the time of closing
of the purchase by Borrower of the Property or at any time ceases to be a valid second priority
lien on the Property.

          (i) Any lien or other monetary encumbrance is imposed against the Property; provided,
however, that in the event that a lien or monetary encumbrance is imposed against the Property
without the consent of Borrower, a Maturity Event shall not occur until the lien or other monetary
encumbrance is imposed against the Property for a period of at least thirty (30) days.

          (j) One (1) year following the death of the Borrower.

          (k) Borrower defaults in his obligation to pay any sum or to perform any obligation,
which is secured by a deed of trust, mortgage, lien, or other encumbrance on the Property (other
than the Deed of Trust).

          (l) The occurrence of any event which causes the Loan and transactions contemplated
under the Loan Documents to be prohibited under Applicable Law, including any prohibition of loans
to officers of public companies under federal or state law.

     5. LATE CHARGE: There shall be no late charge apart from the acceleration of Principal
and the accrual of interest.

A-5

 

     6. BORROWER’S REPRESENTATIONS: Borrower hereby makes the following representations and
warranties to the Lender and acknowledges that Lender is relying on such representations in making
the loan:

          6.1 Borrower shall have good and marketable title to the Property free and clear of any
security interests, liens or encumbrances other than the Deed of Trust in favor of Lender securing
this Note, the first deed of trust in favor of the first priority lien holder and joint ownership
of the property with Borrower’s spouse;

          6.2 Other than the consent of Borrower’s spouse and the holder of the first priority lien on
the Property, the consent of no other person or entity is required to grant to Lender the security
interest in the Property evidenced by the Deed of Trust;

          6.3 There are no actions, proceedings, claims, or disputes pending or, to the Borrower’s
knowledge, threatened against or affecting Borrower or the Property.

     7. BORROWERS’ ADDITIONAL OBLIGATIONS: Borrower shall take any and all further actions that may
from time to time be required to ensure that the Deed of Trust creates a valid second priority lien
on the Property in favor of the Lender as security for the Note. Borrower shall not further
encumber the Property or permit any lien to encumber the Property. Upon request by Lender, but not
more frequently than once during any calendar year, Borrower shall furnish evidence reasonably
satisfactory to the Lender that: (i) Borrower has good and marketable title to the Property; (ii)
the consent of no other person or entity is required to grant a second priority security interest
in the Property to the Lender; (iii) the Deed of Trust is a second priority security interest in the
Property, and (iv) there are no other deeds of trust, mortgages or encumbrances against the
Property. If it should be hereafter determined that there are defects against title or matters
which could result in defects against title to the Property, or that the consent of another person
or entity is required to grant to and perfect in the Lender a valid second-priority lien on the
Property, Borrower shall promptly take all action necessary to remove such defects and to obtain
such consent and grant (or cause to be granted) and perfect such lien on the Property. Failure of
the Deed of Trust to be a valid second lien against the Property shall be deemed a Maturity Event
as aforesaid.

     8. NOTICE: This Note is subject to Section 2924(i) and 2966 of the California Civil Code which
provides that the holder of this Note shall give written notice to Borrower or his
successors-in-interest, of prescribed information (as set forth in said Civil Code Sections) at
least ninety (90) days and not more than one hundred and fifty (150) days before any balloon
payment is due.

     9. ATTORNEYS’ FEES: In the event of Borrower’s default hereunder, Borrower shall pay all costs
of collection, including reasonable attorneys’ fees incurred by the holder hereof on account of
such collection, whether or not suit is filed hereon.

A-6

 

     10. WAIVER: The waiver by Lender of any breach of or default under any term, covenant or
condition contained herein or in any other agreement referred to above shall not be deemed to be
a waiver of any subsequent breach of or default under the same or any other such term, covenant
or condition.

     11. NO USURY: Borrower hereby represents and warrants that at no time shall the proceeds of
the indebtedness evidenced hereby be used “primarily for personal, family, or household purposes”
as that term is defined and used in Article XV of the California Constitution (as amended from
time to time). Anything in this Note to the contrary notwithstanding, it is expressly stipulated
and agreed that the intent of Borrower and Lender are to comply at all times with all usury and
other laws relating to this Note. If the laws of the State of California would now or hereafter
render usurious, or are revised, repealed or judicially interpreted so as to render usurious, any
amount called for under this Note, or contracted for, charged or received with respect to the loan
evidenced by this Note, or if any prepayment by Borrower results in Borrower having paid any
interest in excess of that permitted by law, then it is Borrower’s and Lender’s express intent
that all excess amounts theretofore collected by Lender be credited to the principal balance of
this Note (or, if this Note has been paid in full, refunded to Borrower), and the provisions of
this Note immediately be deemed reformed and the amounts therefor collectible hereunder reduced,
without the necessity of execution of any new document, so as to comply with the then applicable
law, but so as to permit the recovery of the fullest amount otherwise called for hereunder.

     12. PREPAYMENT: Borrower may prepay all or any portion of this Note at any time prior to the
Maturity Date, with no premium or penalty.

     13. GENERAL PROVISIONS: This Note shall be governed by and construed in accordance with the
laws of the State of California. The makers of this Note hereby waive presentment for payment,
protest and demand, notice of protest, demand and dishonor and nonpayment of this Note, and consent
that Lender may extend the time for payment or otherwise modify the terms of payment or any part of
the whole of the debt evidenced by this Note, at the request of any person liable hereon, and such
consent shall not alter nor diminish the liability of any person. Borrower hereby waives the
defense of the statute of limitations in any action on this Note to the extent permitted by law.
Time is of the essence of this Note, the Deed of Trust and any other document executed by Borrower
in connection therewith. Liability hereunder shall be joint and several among Borrower and all
other persons and entities now or hereafter liable for all or any part of the Loan.

     14. ACKNOWLEDGEMENT BY BORROWER: THIS NOTE, THE LOAN AGREEMENT, THE DEED OF TRUST, AND ALL
RELATED DOCUMENTATION ARE EXECUTED VOLUNTARILY AND WITHOUT ANY DURESS OR UNDUE INFLUENCE ON THE
PART OF OR ON BEHALF OF THE PARTIES HERETO, WITH THE FULL INTENT OF CREATING THE OBLIGATIONS AND
SECURITY

A-7

 

INTERESTS DESCRIBED HEREIN AND THEREIN. THE PARTIES ACKNOWLEDGE THAT: (a) THEY HAVE READ SUCH
DOCUMENTATION; (b) THEY HAVE BEEN REPRESENTED IN THE PREPARATION, NEGOTIATION AND EXECUTION OF SUCH
DOCUMENTATION BY LEGAL COUNSEL OF HIS OWN CHOICE; (c) THEY UNDERSTAND THE TERMS AND CONSEQUENCES OF
THIS NOTE, THE LOAN AGREEMENT, THE DEED OF TRUST, AND ALL RELATED AGREEMENTS AND DOCUMENTATION AND
THE OBLIGATIONS THEY CREATE; AND (d) THEY ARE FULLY AWARE OF THE LEGAL AND BINDING EFFECT OF THIS
NOTE, THE DEED OF TRUST AND THE OTHER DOCUMENTS CONTEMPLATED BY OR ENTERED INTO IN CONNECTION WITH
THIS NOTE.

IN WITNESS WHEREOF, Borrower has executed this Note as of the day and year first above written.

	 
	/s/ Thomas B. King
 
 Thomas
B. King

A-8

 

LOAN EXTINGUISHMENT AGREEMENT

     THIS LOAN EXTINGUISHMENT AGREEMENT (the “Agreement”) is made and entered into as of December
21, 2005 by and between Thomas B. King (“King”) and Alexza Pharmaceuticals, Inc. (“Alexza”).

RECITALS

	A.	 	King is indebted to Alexza in the principal amount of $1,200,000 as evidenced by a certain
promissory note (the “Note”).
	 
	B.	 	Subject to the terms and conditions of the Modification Agreement dated as of January 20,
2005, the Note is to be repaid by King immediately before the filing of a Registration
Statement by Alexza with the Securities and Exchange Commission (the “SEC”), and Alexza has
the option to extinguish the Note and provide King additional funds to pay the related federal
and tax withholding in return for cancellation of certain options to purchase the common stock
of Alexza (“Options”).
	 
	C.	 	Subject to the terms and conditions of this Agreement, Alexza extinguishes the Note, and King
agrees that a portion of his Options will have their exercise prices increased as set forth
below.
	 
	 	 	THE PARTIES AGREE AS FOLLOWS:

1.
Extinguishment of Note. Subject to the terms and conditions of this Agreement, Alexza
hereby unconditionally extinguishes and cancels the Note and releases King from all obligations
thereunder and further releases any security interest Alexza has in King’s residence at 91 James
Avenue, Atherton, California. Alexza shall provide $868,965 in respect of the tax obligations
resulting from such forgiveness, which shall be paid to King net of any required withholdings no
later than January 15, 2006. King shall be responsible for paying all taxes resulting from the
extinguishment of the Note and the payment made hereunder.

2. Modification of Option Exercise Price. King agrees that the exercise price of a
number of his Options will be increased to a price equal to (a)

 

 

the price to public in Alexza’s initial public offering (“IPO”), (b) if Alexza is sold prior to
consummation of an IPO (a “Sale”), the price per share paid to the holders of Alexza’s common stock
in such transaction, or (c) if neither of the foregoing has occurred prior to June 30, 2006, the
fair market value of Alexza’s common stock as determined by Alexza’s board of directors on such
date (the price so determined being referred to as the “New Exercise Price”). The number of Options
to be so repriced shall be determined by dividing $2,068,965 by the difference between the New
Exercise Price and the current Option exercise price of $0.20. For example, if the price to public
in the IPO is $1.80, the number of Options to be repriced would be
$2,068,965/($1.80 - $0.20) = 1,293,103. Any remaining Options held by King would continue to have their current exercise price.
If the number of Options to be repriced resulting from the application of the foregoing formula
would exceed the number of Options then held by King, all of King’s Options would be repriced to
the New Exercise Price and King would have no further obligations to Alexza hereunder. The vesting
schedule and other terms of all Options would remain the same. King agrees to deposit with Alexza’s
Secretary all option agreements evidencing the Options and he agrees that he may not exercise any
such Options until the New Exercise Price has been established; provided, however, that in the
event of a Sale the Company shall make arrangements to permit King to exercise his Options prior to
or concurrently with the closing of any such transaction.

3. Arbitration. Any and all disputes arising from or related to this Agreement will be
resolved by binding arbitration to be held in Santa Clara County, California pursuant to the rules
and regulations of the American Arbitration Association.

4. Entire Agreement. This Agreement and the Modification Agreement together represent the
entire agreement between the parties relating to the subject matter hereof and supersedes any and
all prior and contemporaneous discussions, understandings, correspondence and agreements. The terms
set forth in this Agreement supersede any contrary provisions contained in the Modification
Agreement.

 

 

IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above written.

	 	 	 	 	 	 	 	 	 
	ALEXZA 

	 PHARMACEUTICALS, INC.	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	By 

	/s/ A. J. Moretti
	 	 	 	/s/ Thomas B. King
	 	 
	 

	 
	 	 	 	 	 	 
	 

	 	 	 	 	 	Thomas B. King	 	 

 

 

PROMISSORY NOTE SECURED BY DEED OF TRUST

(HOUSING RELOCATION LOAN — I.R.C. Section 1.7872-5-(T))

	 	 	 	 	 
	December 20, 2004

	 	$	500,000.00	 

Palo Alto, California

     1. FOR VALUE RECEIVED, the undersigned, James V. Cassella (“Borrower”), promises to pay to the
order of Alexza Molecular Delivery Corporation, a Delaware corporation (“Lender”), at 1001 East
Meadow Circle, Palo Alto, California 94303 (or at such other place as Lender may from time to time
designate by written notice to Borrower), in lawful money of the United States, the principal sum
of Five Hundred Thousand Dollars ($500,000.00) (the “Principal”), without interest until a Maturity
Event and thereafter together with interest thereon at the rate of one and forty-nine hundredths
percent (1.58%) per annum.

     2. PAYMENT: The Principal and interest, if any, due pursuant to this Promissory Note
Secured by Deed of Trust (this “Note”) shall be paid as follows:

          2.1 Upon the occurrence of a Maturity Event (as defined herein), Borrower shall pay to
Lender all amounts due under this Note.

          2.2 Subject to the provisions of Section 4 herein, the principal amount of this Note shall be
due and payable as follows:

               (a) In the event that Borrower voluntarily terminates his
employment with Lender without “good reason,” the Principal shall be due and payable within thirty
(30) days of such termination date. As used herein, “good reason” shall mean the occurrence of any
of the following events without the Borrowers written consent:

                    (i) a substantial diminution in the nature, status or prestige of Borrower’s
responsibilities, title or reporting level pursuant to the employment offer letter from Lender to
Borrower dated May 7, 2004 (the “Offer Letter”), or the addition of responsibilities of a nature,
status or prestige inconsistent with the office of Chief Executive Officer and President of a
company such as Lender;

                    (ii) if and only if Borrower has relocated his home to the San Francisco Bay area,
California, the relocation of Lender’s executive offices or principal business location to a point
more than fifty (50) miles from the Palo Alto, California area;

A-1

 

                    (iii) a material reduction by Lender of Borrower’s annual salary or annual bonus as
initially set forth in the Offer Letter or as the same may be increased from time to time;

                    (iv) any action by Lender (including the elimination of benefit plans without providing
substitutes thereof or the reduction of Borrower’s benefits thereunder) that would substantially
diminish the aggregate value of Borrower’s fringe benefits as they exist at such time;

                    (v) a
failure by Lender to obtain from any successor, before the succession takes place, an agreement to assume and perform all of the terms and
conditions of the Offer Letter; or

                    (vi) a material breach of the Offer Letter by Lender.

               (b) In the event that Lender terminates Borrower’s employment with Lender other than for
“cause,” the Principal shall be due and payable within thirty (30) days of such termination date,
provided, however, that if Borrower executes a waiver of all claims against Lender in a form
reasonably satisfactory to Lender, the Principal shall be due and payable on the date which is 12
months following the termination date. As used herein, “cause” shall mean the occurrence of any of
the following events:

                    (i) Borrower’s repeated failure to use reasonable efforts to satisfactorily perform his
employment duties after written notice, by the Board of Directors of Lender (the “Board”), of such
deficiency and an opportunity to cure within a reasonable period;

                    (ii) Borrower has committed an act that is, in the opinion of the Board, intended to or
does materially injure the business of Lender;

                    (iii) Borrower has refused or failed to follow lawful and
reasonable directions of the Board, after written notice by the Board and a reasonable period
thereafter to cure such performance;

                    (iv) Borrower has been convicted of a felony involving moral turpitude that is likely, in
the opinion of the Board, to inflict or has inflicted material injury on the business of Lender;

                    (v) a determination by the Board that Borrower has
engaged in conduct constituting sexual harassment of any current or former employee of Lender; or

                    (vi) a determination by the Board that Borrower is, or has been, engaging or in any manner
participating in any activity which is directly competitive with, or intentionally injurious to,
Lender.

A-2

 

               (c) In the event that Lender offers its securities to the public, pursuant to a registration
statement filed with the Securities and Exchange Commission, in an initial public offering (“IPO”),
the Principal shall be due and payable on the earliest date of (i) three (3) years after the date
upon which Lender’s securities are first sold to the public in the IPO, or (ii) such date as the
Board, upon the advice of counsel, deems reasonably necessary to comply with “Applicable Law.” As
used herein, “Applicable Law” means any and all laws of whatever jurisdiction, within or without
the United States, including, but not limited to, the Sarbanes-Oxley Act of 2002, and the rules of
any stock exchange or quotation system on which Lender’s securities are then listed or quoted,
applicable to the taking or refraining from taking of any action under this Note.

               If at the time of the IPO, Applicable Law does not permit Lender to have this Note
outstanding, this Note shall become due and payable no later than one day before Lender files a
Registration Statement on form S-1 under the Securities Act of 1933 in connection with the IPO.
Lender shall give Borrower 30 days written notice of its planned
IPO filing date, provided, however,
that the Lender’s rights herein shall not be affected by failure to give such notice. Prior to the
IPO filing date, Lender shall have the right (but not the obligation) to repurchase (via a cash
payment to you) a portion of Borrower’s option having a Value (as defined below), determined on an
after tax basis, of up to $500,000. such cash payment would be subject to applicable income and
employment tax withholding. The Value would equal the difference between the then fair market value
of one share of the Company’s Common Stock minus the per share exercise price of your option,
multiplied by the number of option shares so surrendered. For example, if at the time Lender
exercised this right, the fair market value of the Common Stock was $2.70 per option share, the
option exercise price was $0.20 per share, and the combined federal and state effective tax rate
was 42%, Lender would be entitled to exercise such right as to 344,828 shares. (Calculation:
344,828 shares x ($2.70-$0.20)/share = $862,070 x (1-.42) = $500,000). The vesting of Borrower’s
option would be accelerated to the extent necessary to permit the repurchase amount elected by the
company.

               (d) In the event of a “Fundamental Corporate Transaction”, the Principal shall be due and
payable on the date which is 12 months following the effective date of the fundamental corporate
transaction. As used herein, a “Fundamental Corporate Transaction” shall mean:

                    (i) a merger or consolidation in which Lender is not the surviving corporation (other
than a merger or consolidation with a wholly-owned subsidiary, a reincorporation of Lender in a
different jurisdiction, or other transaction in which there is no substantial change in the
stockholders of Lender or their relative stock holdings);

                    (ii) a merger in which Lender is the surviving corporation but after which the
stockholders of Lender immediately prior to such merger (other than

A-3

 

any stockholder that merges, or which owns or controls another corporation that merges, with Lender
in such merger) cease to own their shares or other equity interest in Lender;

                    (iii) the sale of all or substantially all of the assets of Lender; or

                    (iv) the acquisition, sale, or transfer of more than 50% of the outstanding shares of
Lender by tender offer or similar transaction.

          2.3 Principal and interest shall be payable in lawful money of the United States. Interest
shall be calculated on the basis of a 360-day year consisting of twelve (12) months, each of thirty
(30) days, and shall compound annually. Each payment shall be applied first to accrued interest,
then to any other amounts (other than principal) payable hereunder as designated by Lender, and
then to reduce Principal.

          2.4 All payments made hereunder shall be made by Borrower free and clear of, and without
deduction for, any and all present and future taxes, levies, charges, deductions and withholdings.
Borrower shall pay upon demand any stamp or other taxes, levies or charges of any jurisdiction with
respect to the execution, delivery, performance and enforcement of this Note.

     3. SECURITY: This Note is secured by that certain Second Deed of Trust (the “Deed of Trust”)
of even date herewith made by Borrower, as trustor, to James V. Cassella, as trustee, for the
benefit of Lender, as beneficiary, which shall be recorded in the Official Records of the County of
Santa Clara, State of California, encumbering certain real property commonly known as 521 Felicia
Way, Los Altos, County of Santa Clara, State of California (the “Property”), described with
particularity in the Deed of Trust, which Borrower intends to occupy as his principal place of
residence. The Deed of Trust provides, among other things, as follows:

“In the event the Property or any part thereof, or any interest therein is sold,
conveyed or alienated by the Trustor, whether voluntarily or involuntarily, except
as prohibited by law, all obligation secured by this instrument, irrespective of the
maturity dates express therein, at the option of the holder hereof and without
demand or notice, shall immediately become due and payable.”

     4. MATURITY EVENT: Upon the occurrence of a Maturity Event (as hereinafter defined), the
entire unpaid Principal balance shall become immediately due and payable without further demand or
notice to Borrower. To the extent permitted by law, any of the following events shall be a
“Maturity Event” under this Note and the Deed of Trust:

A-4

 

          (a) Borrower shall fail to pay any amount of the Principal on this Note when due and shall
fail to cure such non-payment within ten (10) days following written notice of such delinquency.

          (b) There shall occur a breach or default in the performance of any obligation of Borrower
contained in this Note, the Deed of Trust, the Employee Loan Agreement executed concurrently
herewith (the “Loan Documents”), or any other agreement now or hereafter entered into by Borrower,
on the one hand, and the Lender, on the other hand, with respect to the Property.

          (c) There shall occur a breach or default in the performance of any obligation of Borrower in
any other deed of trust or other security instrument (whether superior or subordinate in rights to
the Deed of Trust) now or hereafter encumbering the Property.

          (d) Borrower shall sell, convey, encumber, grant any lien upon, or otherwise alienate the
Property, or any part thereof, or any interest therein, or shall be divested of his title or any
interest therein in any manner or way, whether voluntarily or involuntarily, without the written
consent of the Lender being first had and obtained.

          (e) Borrower (i) admits in writing his inability to pay debts, (ii) makes an assignment for
the benefit of creditors, (iii) files a voluntary petition in bankruptcy, effect a plan or other
arrangement with creditors, liquidate his assets under arrangement with creditors, or liquidate his
assets under court supervision, (iv) has an involuntary petition in bankruptcy filed against him
that is not discharged within sixty (60) days after such petition is filed, or (v) applies for or
permit the appointment of a receiver or trustee or custodian for any of his property or assets
which shall not have been discharged within sixty (60) days after the date of appointment.

          (f) The Principal shall have become due and payable, upon the happening of certain
events, on such dates as are set forth in Section 2.2 herein.

          (g) Any representation or warranty of Borrower contained herein or in any certificate or
agreement entered into between Borrower for the benefit of Lender in connection herewith shall
prove to be false or misleading in any material respect.

          (h) The Deed of Trust is not recorded against the Property at the closing of the purchase
by Borrower of the Property or at any time ceases to be a valid second priority lien on the
Property.

          (i) Any lien or other monetary encumbrance is imposed against the Property; provided,
however, that in the event that a lien or monetary encumbrance is imposed against the Property
without the consent of Borrower, a Maturity Event shall not

A-5

 

occur until the lien or other monetary encumbrance is imposed against the Property for a period
of at least thirty (30) days.

          (j) One (1) year following the death of the Borrower.

          (k) Borrower defaults in his obligation to pay any sum or to perform any obligation,
which is secured by a deed of trust, mortgage, lien, or other encumbrance on the Property (other
than the Deed of Trust).

          (l) The occurrence of any event which causes the Loan and transactions contemplated
under the Loan Documents to be prohibited under Applicable Law, including any prohibition of loans
to officers of public companies under federal or state law.

     5. LATE CHARGE: There shall be no late charge apart from the acceleration of Principal and the
accrual of interest.

     6. BORROWER’S REPRESENTATIONS: Borrower hereby makes the following representations and
warranties to the Lender and acknowledges that Lender is relying on such representations in making
the loan:

          6.1 Borrower shall have good and marketable title to the Property free and clear of any
security interests, liens or encumbrances other than the Deed of Trust in favor of Lender securing
this Note, the first priority lien on the Property and the community property interest of
Borrower’s spouse.

          6.2 Other than the consent of Borrower’s spouse and the holder of the first priority lien on
the property no other consent is required to grant to Lender the security interest in the Property
evidenced by the Deed of Trust;

          6.3 There are no actions, proceedings, claims, or disputes pending or, to the Borrower’s
knowledge, threatened against or affecting Borrower or the Property.

     7. BORROWERS’ ADDITIONAL OBLIGATIONS: Borrower shall take any and all further actions that may
from time to time be required to ensure that the Deed of Trust creates a valid second priority lien
on the Property in favor of the Lender as security for the Note. Borrower shall not further
encumber the Property or permit any lien to encumber the Property. Upon request by Lender, but not
more frequently than once during any calendar year, Borrower shall furnish evidence reasonably
satisfactory to the Lender that: (i) Borrower has good and marketable title to the Property; (ii)
the consent of no other person or entity is required to grant a second priority security interest
in the Property to the Lender; (iii) the Deed of Trust is a second priority security interest in
the Property, and (iv) there are no other deeds of trust, mortgages or encumbrances against the
Property. If it should be hereafter determined that there are defects against title or matters
which could result in defects against title to the Property, or that the consent of

A-6

 

another person or entity is required to grant to and perfect in the Lender a valid second-priority
lien on the Property, Borrower shall promptly take all action necessary to remove such defects and
to obtain such consent and grant (or cause to be granted) and perfect such lien on the Property.
Failure of the Deed of Trust to be a valid second lien against the Property shall be deemed a
Maturity Event as aforesaid.

     8. NOTICE: This Note is subject to Section 2924(i) and 2966 of the California Civil Code which
provides that the holder of this Note shall give written notice to Borrower or his
successors-in-interest, of prescribed information (as set forth in said Civil Code Sections) at
least ninety (90) days and not more than one hundred and fifty (150) days before any balloon
payment is due.

     9. ATTORNEYS’ FEES: In the event of Borrower’s default hereunder, Borrower shall pay all costs
of collection, including reasonable attorneys’ fees incurred by the holder hereof on account of
such collection, whether or not suit is filed hereon.

     10. WAIVER: The waiver by Lender of any breach of or default under any term, covenant or
condition contained herein or in any other agreement referred to above shall not be deemed to be a
waiver of any subsequent breach of or default under the same or any other such term, covenant or
condition.

     11. NO USURY: Borrower hereby represents and warrants that at no time shall the proceeds of
the indebtedness evidenced hereby be used “primarily for personal, family, or household purposes”
as that term is defined and used in Article XV of the California Constitution (as amended from time
to time). Anything in this Note to the contrary notwithstanding, it is expressly stipulated and
agreed that the intent of Borrower and Lender are to comply at all times with all usury and other
laws relating to this Note. If the laws of the State of California would now or hereafter render
usurious, or are revised, repealed or judicially interpreted so as to render usurious, any amount
called for under this Note, or contracted for, charged or received with respect to the loan
evidenced by this Note, or if any prepayment by Borrower results in Borrower having paid any
interest in excess of that permitted by law, then it is Borrower’s and Lender’s express intent that
all excess amounts theretofore collected by Lender be credited to the principal balance of this
Note (or, if this Note has been paid in full, refunded to Borrower), and the provisions of this
Note immediately be deemed reformed and the amounts therefor collectible hereunder reduced, without
the necessity of execution of any new document, so as to comply with the then applicable law, but
so as to permit the recovery of the fullest amount otherwise called for hereunder.

     12. PREPAYMENT: Borrower may prepay all or any portion of this Note at any time prior to the
Maturity Date, with no premium or penalty.

     13. GENERAL PROVISIONS: This Note shall be governed by and construed in accordance with the
laws of the State of California. The makers of this Note hereby

A-7

 

waive presentment for payment, protest and demand, notice of protest, demand and dishonor and
nonpayment of this Note, and consent that Lender may extend the time for payment or otherwise
modify the terms of payment or any part of the whole of the debt evidenced by this Note, at the
request of any person liable hereon, and such consent shall not alter nor diminish the liability of
any person. Borrower hereby waives the defense of the statute of limitations in any action on this
Note to the extent permitted by law. Time is of the essence of this Note, the Deed of Trust and any
other document executed by Borrower in connection therewith. Liability hereunder shall be joint and
several among Borrower and all other persons and entities now or hereafter liable for all or any
part of the Loan.

     14. ACKNOWLEDGEMENT BY BORROWER: THIS NOTE, THE LOAN AGREEMENT, THE DEED OF TRUST, AND
ALL RELATED DOCUMENTATION ARE EXECUTED VOLUNTARILY AND WITHOUT ANY DURESS OR UNDUE INFLUENCE ON THE
PART OF OR ON BEHALF OF THE PARTIES HERETO, WITH THE FULL INTENT OF CREATING THE OBLIGATIONS AND
SECURITY INTERESTS DESCRIBED HEREIN AND THEREIN. THE PARTIES ACKNOWLEDGE THAT: (a) THEY HAVE READ
SUCH DOCUMENTATION; (b) THEY HAVE BEEN REPRESENTED IN THE PREPARATION, NEGOTIATION AND EXECUTION OF
SUCH DOCUMENTATION BY LEGAL COUNSEL OF HIS OWN CHOICE; (c) THEY UNDERSTAND THE TERMS AND
CONSEQUENCES OF THIS NOTE, THE LOAN AGREEMENT, THE DEED OF TRUST, AND ALL RELATED AGREEMENTS AND
DOCUMENTATION AND THE OBLIGATIONS THEY CREATE; AND (d) THEY ARE FULLY AWARE OF THE LEGAL AND
BINDING EFFECT OF THIS NOTE, THE DEED OF TRUST AND THE OTHER DOCUMENTS CONTEMPLATED BY OR ENTERED
INTO IN CONNECTION WITH THIS NOTE.

IN WITNESS WHEREOF, Borrower has executed this Note as of the day and year first above
written.

	 
	/s/ James V. Cassella
 
James
V. Cassella

A-8

 

LOAN EXTINGUISHMENT AGREEMENT

     THIS LOAN EXTINGUISHMENT AGREEMENT (the “Agreement”) is made and entered into as of December
21, 2005 by and between James V. Cassella (“Cassella”) and Alexza Pharmaceuticals, Inc. (“Alexza”).

RECITALS

	A.	 	Cassella is indebted to Alexza in the principal amount of $500,000 as evidenced by a certain
promissory note (the “Note”).
	 
	B.	 	Subject to the terms and conditions of the Loan Agreement dated as of January 20, 2005, the
Note is to be repaid by Cassella immediately before the filing of a Registration Statement by
Alexza with the Securities and Exchange Commission (the
“SEC”), and Alexza has the option to
extinguish the Note and provide Cassella additional funds to pay the related federal and tax
withholding in return for cancellation of certain options to purchase the common stock of
Alexza (“Options”).
	 
	C.	 	Subject to the terms and conditions of this Agreement, Alexza extinguishes the Note and
Cassella agrees that a portion of his Options will have their exercise prices increased as set
forth below.
	 
	 	 	THE PARTIES AGREE AS FOLLOWS:

1. Extinguishment of Note. Subject to the terms and conditions of this Agreement, Alexza
hereby unconditionally extinguishes and cancels the Note and releases Cassella from all
obligations thereunder and further releases any security interest Alexza has in Cassella’s
residence at 521 San Felicia Way, Los Altos, California. Alexza shall provide $362,069 in
respect of the tax obligations resulting from such forgiveness, which shall be paid to Cassella
net of any required withholdings no later than January 15, 2006.
Cassella shall be responsible
for paying all taxes resulting from the forgiveness of the Note and the payment made hereunder.

2. Modification of Option Exercise Price. Cassella agrees that the exercise
price of a number of his Options will be increased to a price

 

 

equal to (a) the price to public in Alexza’s initial public offering (“IPO”), (b) if Alexza is
sold prior to consummation of an IPO (a “Sale”), the price per share paid to the holders of
Alexza’s common stock in such transaction, or (c) if neither of the foregoing has occurred prior to
June 30, 2006, the fair market value of Alexza’s common stock as determined by Alexza’s board of
directors on such date (the price so determined being referred to as the “New Exercise Price”). The
number of Options to be so repriced shall be determined by dividing $862,069 by the difference
between the New Exercise Price and the current Option exercise price of $0.20. For example, if the
price to public in the IPO is $1.80, the number of Options to be repriced would be $862,069 /($1.80 - $0.20) = 538,793. Any remaining Options held by Cassella would continue to have their current
exercise price. If the number of Options to be repriced resulting from the application of the
foregoing formula would exceed the number of Options then held by Cassella, all of the Options
would be repriced to the New Exercise Price, and Cassella would have no further obligations to
Alexza hereunder. The vesting schedule and other terms of all Options would remain the same.
Cassella agrees to deposit with Alexza’s Secretary all option agreements evidencing the Options and
he agrees that he may not exercise any such Options until the New Exercise Price has been
established; provided, however, that in the event of a Sale the Company shall make arrangements to
permit Cassella to exercise his Options prior to or concurrently with the closing of any such
transaction.

3.
Arbitration. Any and all disputes arising from or related to this Agreement will be resolved by
binding arbitration to be held in Santa Clara County, California pursuant to the rules and
regulations of the American Arbitration Association.

4. Entire Agreement. This Agreement and the Loan Agreement together represent the entire
agreement between the parties relating to the subject matter hereof and supersedes any and all
prior and contemporaneous discussions, understandings, correspondence and agreements. The terms set
forth in this Agreement supersede any contrary provisions contained in the Loan Agreement.

 

 

     IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above
written.

	 	 	 	 	 	 	 	 	 
	ALEXZA PHARMACEUTICALS, INC.
	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	By  

	/s/ A. J. Moretti
	 	 	 	/s/ James V. Cassella
	 	 
	 

	 
	 	 	 	 	 	 
	 

	 	 	 	 	 	James V. Cassella	 	 

 

 

FORM OF PROMISSORY NOTE

PROMISSORY
NOTE SECURED BY DEED OF TRUST

(HOUSING RELOCATION LOAN — I.R.C. Section 1.7872-5-(T))

			
	 
	April 8, 2004
	 	$500,000.00

Palo Alto, California

     1. FOR VALUE RECEIVED, the undersigned, Jeffrey S. Williams (“Borrower”), promises to pay to
the order of Alexza Molecular Delivery Corporation, a Delaware corporation (“Lender”), at 1001
East Meadow Circle, Palo Alto, California 94303 (or at such other place as Lender may from time to
time designate by written notice to Borrower), in lawful money of the United States, the principal
sum of Five Hundred Thousand Dollars ($500,000.00) (the “Principal”), without interest until a
Maturity Event and thereafter together with interest thereon at the rate of one and forty-nine
hundredths percent (1.58%) per annum.

     2. PAYMENT: The Principal and interest, if any, due pursuant to this Promissory Note Secured
by Deed of Trust (this “Note”) shall be paid as follows:

          2.1 Upon the occurrence of a Maturity Event (as defined herein), Borrower shall pay to Lender
all amounts due under this Note.

          2.2 Subject to the provisions of Section 4 herein, the principal amount of this Note shall be
due and payable as follows:

               (a) In the event that Borrower voluntarily terminates his
employment with Lender without “good reason,” the Principal shall be due and payable within thirty
(30) days of such termination date. As used herein, “good reason” shall mean the occurrence of any
of the following events without the Borrowers written consent:

                    (i) a substantial diminution in the nature, status or prestige of Borrower’s
responsibilities, title or reporting level pursuant to the employment offer letter from Lender to
Borrower dated February 24, 2004 (the “Offer Letter”), or the addition of responsibilities of a
nature, status or prestige inconsistent with the office of Chief Executive Officer and President of
a company such as Lender;

                    (ii) if and only if Borrower has relocated his home to the San Francisco Bay area,
California, the relocation of Lender’s executive offices or

A-1

 

principal business location to a point more than fifty (50) miles from the Palo Alto, California
area;

                    (iii) a material reduction by Lender of Borrower’s annual salary or annual bonus as
initially set forth in the Offer Letter or as the same may be increased from time to time;

                    (iv) any action by Lender (including the elimination of benefit plans without providing
substitutes thereof or the reduction of Borrower’s benefits thereunder) that would substantially
diminish the aggregate value of Borrower’s fringe benefits as they exist at such time;

                    (v) a failure by Lender to obtain from any successor,
before the succession takes place, an agreement to assume and perform all of the terms and
conditions of the Offer Letter; or

                    (vi) a material breach of the Offer Letter by Lender.

               (b) In the event that Lender terminates Borrower’s employment with Lender other than for
“cause,” the Principal shall be due and payable within thirty (30) days of such termination date,
provided, however, that if Borrower executes a waiver of all claims against Lender in a form
reasonably satisfactory to Lender, the Principal shall be due and payable on the date which is 12
months following the termination date. As used herein, “cause” shall mean the occurrence of any of
the following events:

                    (i) Borrower’s repeated failure to use reasonable efforts to satisfactorily perform his
employment duties after written notice, by the Board of Directors of Lender (the “Board”), of such
deficiency and an opportunity to cure within a reasonable period;

                    (ii) Borrower has committed an act that is, in the opinion of the Board, intended to or
does materially injure the business of Lender;

                    (iii) Borrower has refused or failed to follow lawful and
reasonable directions of the Board, after written notice by the Board and a reasonable period
thereafter to cure such performance;

                    (iv) Borrower has been convicted of a felony involving moral turpitude that is likely, in
the opinion of the Board, to inflict or has inflicted material injury on the business of Lender;

                    (v) a determination by the Board that Borrower has
engaged in conduct constituting sexual harassment of any current or former employee of Lender; or

A-2

 

                    (vi) a determination by the Board that Borrower is, or has been, engaging or in any
manner participating in any activity which is directly competitive with, or intentionally
injurious to, Lender.

               (c) In the event that Lender offers its securities to the public, pursuant to a registration
statement filed with the Securities and Exchange Commission, in an initial public offering (“IPO”),
the Principal shall be due and payable on the earliest date of (i) three (3) years after the date
upon which Lender’s securities are first sold to the public in the IPO, or (ii) such date as the
Board, upon the advice of counsel, deems reasonably necessary to comply with “Applicable Law.” As
used herein, “Applicable Law” means any and all laws of whatever jurisdiction, within or without
the United States, including, but not limited to, the Sarbanes-Oxley Act of 2002, and the rules of
any stock exchange or quotation system on which Lender’s securities are then listed or quoted,
applicable to the taking or refraining from taking of any action under this Note.

               (d) In the event of a “Fundamental Corporate Transaction”, the Principal shall be due and
payable on the date which is 12 months following the effective date of the fundamental corporate
transaction. As used herein, a “Fundamental Corporate Transaction” shall mean:

                    (i) a merger or consolidation in which Lender is not the surviving corporation (other
than a merger or consolidation with a wholly-owned subsidiary, a reincorporation of Lender in a
different jurisdiction, or other transaction in which there is no substantial change in the
stockholders of Lender or their relative stock holdings);

                    (ii) a merger in which Lender is the surviving corporation
but after which the stockholders of Lender immediately prior to such merger (other than any
stockholder that merges, or which owns or controls another corporation that merges, with Lender
in such merger) cease to own their shares or other equity interest in Lender;

                    (iii) the sale of all or substantially all of the assets of Lender; or

                    (iv) the acquisition, sale, or transfer of more than 50% of the outstanding shares of
Lender by tender offer or similar transaction.

          2.3 Principal and interest shall be payable in lawful money of the United States. Interest
shall be calculated on the basis of a 360-day year consisting of twelve (12) months, each of thirty
(30) days, and shall compound annually. Each payment shall be applied first to accrued interest,
then to any other amounts (other than principal) payable hereunder as designated by Lender, and
then to reduce Principal.

A-3

 

          2.4 All payments made hereunder shall be made by Borrower free and clear of, and without
deduction for, any and all present and future taxes, levies, charges, deductions and withholdings.
Borrower shall pay upon demand any stamp or other taxes, levies or charges of any jurisdiction
with respect to the execution, delivery, performance and enforcement of this Note.

     3. SECURITY: This Note is secured by that certain Second Deed of Trust (the “Deed of
Trust”) of even date herewith made by Borrower, as trustor, to Jeffrey S. Williams, as trustee,
for the benefit of Lender, as beneficiary, which shall be recorded in the Official Records of the
County of Alameda, State of California, encumbering certain real property commonly known as 1382
Via di Salerno, Pleasanton, County of Alameda, State of California (the “Property”), described
with particularity in the Deed of Trust, which Borrower intends to occupy as his principal place
of residence. The Deed of Trust provides, among other things, as follows:

“In the event the Property or any part thereof, or any interest therein is sold,
conveyed or alienated by the Trustor, whether voluntarily or involuntarily, except
as prohibited by law, all obligation secured by this instrument, irrespective of
the maturity dates express therein, at the option of the holder hereof and without
demand or notice, shall immediately become due and payable.”

     4. MATURITY EVENT: Upon the occurrence of a Maturity Event (as hereinafter defined), the
entire unpaid Principal balance shall become immediately due and payable without further demand or
notice to Borrower. To the extent permitted by law, any of the following events shall be a
“Maturity Event” under this Note and the Deed of Trust:

          (a) Borrower shall fail to pay any amount of the Principal on this Note when due and shall
fail to cure such non-payment within ten (10) days following written notice of such delinquency.

          (b) There shall occur a breach or default in the performance of any obligation of Borrower
contained in this Note, the Deed of Trust, the Employee Loan Agreement executed concurrently
herewith (the “Loan Documents”), or any other agreement now or hereafter entered into by Borrower,
on the one hand, and the Lender, on the other hand, with respect to the Property.

          (c) There shall occur a breach or default in the performance of any obligation of Borrower in
any other deed of trust or other security instrument (whether superior or subordinate in rights to
the Deed of Trust) now or hereafter encumbering the Property.

A-4

 

          (d) Borrower shall sell, convey, encumber, grant any lien upon, or otherwise alienate the
Property, or any part thereof, or any interest therein, or shall be divested of his title or any
interest therein in any manner or way, whether voluntarily or involuntarily, without the written
consent of the Lender being first had and obtained.

          (e) Borrower (i) admits in writing his inability to pay debts, (ii) makes an assignment for
the benefit of creditors, (iii) files a voluntary petition in bankruptcy, effect a plan or other
arrangement with creditors, liquidate his assets under arrangement with creditors, or liquidate
his assets under court supervision, (iv) has an involuntary petition in bankruptcy filed against
him that is not discharged within sixty (60) days after such petition is filed, or (v) applies for
or permit the appointment of a receiver or trustee or custodian for any of his property or assets
which shall not have been discharged within sixty (60) days after the date of appointment.

          (f) The Principal shall have become due and payable, upon the happening of certain events, on
such dates as are set forth in Section 2.2 herein.

          (g) Any representation or warranty of Borrower contained herein or in any certificate or
agreement entered into between Borrower for the benefit of Lender in connection herewith shall
prove to be false or misleading in any material respect.

          (h) The Deed of Trust is not recorded against the Property at the closing of the purchase
by Borrower of the Property or at any time ceases to be a valid second priority lien on the
Property.

          (i) Any lien or other monetary encumbrance is imposed against the Property; provided,
however, that in the event that a lien or monetary encumbrance is imposed against the Property
without the consent of Borrower, a Maturity Event shall not occur until the lien or other monetary
encumbrance is imposed against the Property for a period of at least thirty (30) days.

          (j) One (1) year following the death of the Borrower.

          (k) Borrower defaults in his obligation to pay any sum or to perform any obligation,
which is secured by a deed of trust, mortgage, lien, or other encumbrance on the Property (other
than the Deed of Trust).

          (l) The occurrence of any event which causes the Loan and transactions contemplated under
the Loan Documents to be prohibited under Applicable Law, including any prohibition of loans to
officers of public companies under federal or state
law.

     5. LATE CHARGE: There shall be no late charge apart from the acceleration of Principal
and the accrual of interest.

A-5

 

     6. BORROWER’S REPRESENTATIONS: Borrower hereby makes the following representations and
warranties to the Lender and acknowledges that Lender is relying on such representations in making
the loan:

          6.1 Borrower shall have good and marketable title to the Property free and clear of any
security interests, liens or encumbrances other than the Deed of Trust in favor of Lender securing
this Note, the first deed of trust in favor of the first priority lien holder and joint ownership
of the property with Borrower’s spouse;

          6.2 Other than the consent of Borrower’s spouse and the holder of the first priority lien on
the Property, the consent of no other person or entity is required to grant to Lender the security
interest in the Property evidenced by the Deed of Trust;

          6.3 There are no actions, proceedings, claims, or disputes pending or, to the Borrower’s
knowledge, threatened against or affecting Borrower or the Property.

     7. BORROWERS’ ADDITIONAL OBLIGATIONS: Borrower shall take any and all further actions that may
from time to time be required to ensure that the Deed of Trust creates a valid second priority lien
on the Property in favor of the Lender as security for the Note. Borrower shall not further
encumber the Property or permit any lien to encumber the Property. Upon request by Lender, but not
more frequently than once during any calendar year, Borrower shall furnish evidence reasonably
satisfactory to the Lender that: (i) Borrower has good and marketable title to the Property; (ii)
the consent of no other person or entity is required to grant a second priority security interest
in the Property to the Lender; (iii) the Deed of Trust is a second priority security interest in
the Property, and (iv) there are no other deeds of trust, mortgages or encumbrances against the
Property. If it should be hereafter determined that there are defects against title or matters
which could result in defects against title to the Property, or that the consent of another person
or entity is required to grant to and perfect in the Lender a valid second-priority lien on the
Property, Borrower shall promptly take all action necessary to remove such defects and to obtain
such consent and grant (or cause to be granted) and perfect such lien on the Property. Failure of
the Deed of Trust to be a valid second lien against the Property shall be deemed a Maturity Event
as aforesaid.

     8. NOTICE: This Note is subject to Section 2924(i) and 2966 of the California Civil Code which
provides that the holder of this Note shall give written notice to Borrower or his
successors-in-interest, of prescribed information (as set forth in said Civil Code Sections) at
least ninety (90) days and not more than one hundred and fifty (150) days before any balloon
payment is due.

     9. ATTORNEYS’ FEES: In the event of Borrower’s default hereunder, Borrower shall pay all costs
of collection, including reasonable attorneys’ fees incurred by the holder hereof on account of
such collection, whether or not suit is filed hereon.

A-6

 

     10. WAIVER: The waiver by Lender of any breach of or default under any term, covenant or
condition contained herein or in any other agreement referred to above shall not be deemed to be a
waiver of any subsequent breach of or default under the same or any other such term, covenant or
condition.

     11. NO USURY: Borrower hereby represents and warrants that at no time shall the proceeds of
the indebtedness evidenced hereby be used “primarily for personal, family, or household purposes”
as that term is defined and used in Article XV of the California Constitution (as amended from time
to time). Anything in this Note to the contrary notwithstanding, it is expressly stipulated and
agreed that the intent of Borrower and Lender are to comply at all times with all usury and other
laws relating to this Note. If the laws of the State of California would now or hereafter render
usurious, or are revised, repealed or judicially interpreted so as to render usurious, any amount
called for under this Note, or contracted for, charged or received with respect to the loan
evidenced by this Note, or if any prepayment by Borrower results in Borrower having paid any
interest in excess of that permitted by law, then it is Borrower’s and Lender’s express intent that
all excess amounts theretofore collected by Lender be credited to the principal balance of this
Note (or, if this Note has been paid in full, refunded to Borrower), and the provisions of this
Note immediately be deemed reformed and the amounts therefor collectible hereunder reduced, without
the necessity of execution of any new document, so as to comply with the then applicable law, but
so as to permit the recovery of the fullest amount otherwise called for hereunder.

     12. PREPAYMENT: Borrower may prepay all or any portion of this Note at any time prior to the
Maturity Date, with no premium or penalty.

     13. GENERAL PROVISIONS: This Note shall be governed by and construed in accordance with the
laws of the State of California. The makers of this Note hereby waive presentment for payment,
protest and demand, notice of protest, demand and dishonor and nonpayment of this Note, and consent
that Lender may extend the time for payment or otherwise modify the terms of payment or any part of
the whole of the debt evidenced by this Note, at the request of any person liable hereon, and such
consent shall not alter nor diminish the liability of any person. Borrower hereby waives the
defense of the statute of limitations in any action on this Note to the extent permitted by law.
Time is of the essence of this Note, the Deed of Trust and any other document executed by Borrower
in connection therewith. Liability hereunder shall be joint and several among Borrower and all
other persons and entities now or hereafter liable for all or any part of the Loan.

     14. ACKNOWLEDGEMENT BY BORROWER: THIS NOTE, THE LOAN AGREEMENT, THE DEED OF TRUST, AND ALL
RELATED DOCUMENTATION ARE EXECUTED VOLUNTARILY AND WITHOUT ANY DURESS OR UNDUE INFLUENCE ON THE
PART OF OR ON BEHALF OF THE PARTIES HERETO, WITH THE FULL INTENT OF CREATING THE OBLIGATIONS AND
SECURITY

A-7

 

INTERESTS DESCRIBED HEREIN AND THEREIN. THE PARTIES ACKNOWLEDGE THAT: (a) THEY HAVE READ SUCH
DOCUMENTATION; (b) THEY HAVE BEEN REPRESENTED IN THE PREPARATION, NEGOTIATION AND EXECUTION OF SUCH
DOCUMENTATION BY LEGAL COUNSEL OF HIS OWN CHOICE; (c) THEY UNDERSTAND THE TERMS AND CONSEQUENCES OF
THIS NOTE, THE LOAN AGREEMENT, THE DEED OF TRUST, AND ALL RELATED AGREEMENTS AND DOCUMENTATION AND
THE OBLIGATIONS THEY CREATE; AND (d) THEY ARE FULLY AWARE OF THE LEGAL AND BINDING EFFECT OF THIS
NOTE, THE DEED OF TRUST AND THE OTHER DOCUMENTS CONTEMPLATED BY OR ENTERED INTO IN CONNECTION WITH
THIS NOTE.

IN WITNESS WHEREOF, Borrower has executed this Note as of the day and year first above written.

	 	 	 
	/s/
Jeffrey S. Williams
 

Jeffrey S. Williams

	 	 

A-8

 

PROMISSORY NOTE SECURED BY DEED OF TRUST

(HOUSING RELOCATION LOAN — I.R.C. Section 1.7872-5-(T))

			
	April 19, 2005
	 	$100,000.00

Palo Alto, California

     1. FOR VALUE RECEIVED, the undersigned, Jeffrey S. Williams (“Borrower”), promises to pay to
the order of Alexza Molecular Delivery Corporation, a Delaware corporation (“Lender”), at 1001 East
Meadow Circle, Palo Alto, California 94303 (or at such other place as Lender may from time to time
designate by written notice to Borrower), in lawful money of the United States, the principal sum
of One Hundred Thousand Dollars ($100,000.00) (the “Principal”), without interest until a Maturity
Event and thereafter together with interest thereon at the rate of one and forty-nine hundredths
percent (1.59%) per annum.

     2. PAYMENT: The Principal and interest, if any, due pursuant to this Promissory Note Secured
by Deed of Trust (this “Note”) shall be paid as follows:

     2.1 Upon the occurrence of a Maturity Event (as defined herein), Borrower shall pay to Lender
all amounts due under this Note.

     2.2 Subject to the provisions of Section 4 herein, the principal amount of this Note shall be
due and payable as follows:

               (a) In the event that Borrower voluntarily terminates his
employment with Lender without “good reason,” the Principal shall be due and payable within thirty
(30) days of such termination date. As used herein, “good reason” shall mean the occurrence of any
of the following events without the Borrowers written consent:

                    (i) a substantial diminution in the nature, status or prestige
of Borrower’s responsibilities, title or reporting level pursuant to the employment offer letter
from Lender to Borrower dated February 24, 2004 (the “Offer Letter”), or the addition of
responsibilities of a nature, status or prestige inconsistent with the office of Senior Vice
President of a company such as Lender;

                    (ii) the relocation of Lender’s executive offices or
principal business location to a point more than fifty (50) miles from the Palo Alto, California
area;

 

 

                    (iii) a material reduction by Lender of Borrower’s annual salary or annual bonus as
initially set forth in the Offer Letter or as the same may be
increased from time to time;

                    (iv) any
action by Lender (including the elimination of benefit plans without providing
substitutes thereof or the reduction of Borrower’s benefits thereunder) that would substantially
diminish the aggregate value of Borrower’s fringe benefits as they exist at such time;

                    (v) a failure by Lender to obtain from any successor,
before the succession takes place, an agreement to assume and perform all of the terms and
conditions of the Offer Letter; or

                    (vi) a material breach of the Offer Letter by Lender.

               (b) In the event that Lender terminates Borrower’s employment with Lender other than for
“cause,” the Principal shall be due and payable within thirty (30) days of such termination date,
provided, however, that if Borrower executes a waiver of all claims against Lender in a form
reasonably satisfactory to Lender, the Principal shall be due and payable on the date which is 12
months following the termination date. As used herein, “cause” shall mean the occurrence of any of
the following events:

                    (i) Borrower’s repeated failure to use reasonable efforts to satisfactorily perform his
employment duties after written notice, by the Board of Directors of Lender (the “Board”), of such
deficiency and an opportunity to cure within a reasonable period;

                    (ii) Borrower has committed an act that is, in the opinion of the Board, intended to or
does materially injure the business of Lender;

                    (iii) Borrower has refused or failed to follow lawful and
reasonable directions of the Board, after written notice by the Board and a reasonable period
thereafter to cure such performance;

                    (iv) Borrower has been convicted of a felony involving moral turpitude that is likely, in
the opinion of the Board, to inflict or has inflicted material injury on the business of Lender;

                    (v) a determination by the Board that Borrower has
engaged in conduct constituting sexual harassment of any current or former employee of Lender; or

                    (vi) a determination by the Board that Borrower is, or has been, engaging or in any manner
participating in any activity which is directly competitive with, or intentionally injurious to,
Lender.

 

 

               (c) In the event that Lender offers its securities to the public, pursuant to a registration
statement filed with the Securities and Exchange Commission, in an initial public offering (“IPO”),
the Principal shall be due and payable on such date as the Board, upon the advice of counsel, deems
reasonably necessary to comply with “Applicable Law.” As used herein, “Applicable Law” means any
and all laws of whatever jurisdiction, within or without the United States, including, but not
limited to, the Sarbanes-Oxley Act of 2002, and the rules of any stock exchange or quotation system
on which Lender’s securities are then listed or quoted, applicable to the taking or refraining from
taking of any action under this Note.

               (d) In the event of a “Fundamental Corporate Transaction”, the Principal shall be due and
payable on the date which is 12 months following the effective date of the fundamental corporate
transaction. As used herein, a “Fundamental Corporate Transaction” shall mean:

                    (i) a merger or consolidation in which Lender is not the surviving corporation (other
than a merger or consolidation with a wholly-owned subsidiary, a reincorporation of Lender in a
different jurisdiction, or other transaction in which there is no substantial change in the
stockholders of Lender or their relative stock holdings);

                    (ii) a merger in which Lender is the surviving corporation
but after which the stockholders of Lender immediately prior to such merger (other than any
stockholder that merges, or which owns or controls another corporation that merges, with Lender
in such merger) cease to own their shares or other equity interest in Lender;

                    (iii) the sale of all or substantially all of the assets of Lender; or

                    (iv) the acquisition, sale, or transfer of more than 50% of the outstanding shares of
Lender by tender offer or similar transaction.

     2.3 Principal and interest shall be payable in lawful money of the United States. Interest
shall be calculated on the basis of a 360-day year consisting of twelve (12) months, each of thirty
(30) days, and shall compound annually. Each payment shall be applied first to accrued interest,
then to any other amounts (other than principal) payable hereunder as designated by Lender, and
then to reduce Principal.

     2.4 All payments made hereunder shall be made by Borrower free and clear of, and without
deduction for, any and all present and future taxes, levies, charges, deductions and withholdings.
Borrower shall pay upon demand any stamp or other taxes, levies or charges of any jurisdiction with
respect to the execution, delivery, performance and enforcement of this Note.

 

 

     3. SECURITY: This Note is secured by that certain Second Deed of Trust (the “Deed of Trust”)
of even date herewith made by Borrower, as trustor, to Jeffrey S. Williams, as trustee, for the
benefit of Lender, as beneficiary, which shall be recorded in the Official Records of the County of
Alameda, State of California, encumbering certain real property commonly known as 1382 Via di
Salerno, Pleasanton, County of Alameda, State of California (the “Property”), described with
particularity in the Deed of Trust, which Borrower intends to occupy as his principal place of
residence. The Deed of Trust provides, among other things, as follows:

“In the event the Property or any part thereof, or any interest therein is sold,
conveyed or alienated by the Trustor, whether voluntarily or involuntarily, except
as prohibited by law, all obligation secured by this instrument, irrespective of
the maturity dates express therein, at the option of the holder hereof and without
demand or notice, shall immediately become due and payable.”

     4. MATURITY EVENT: Upon the occurrence of a Maturity Event (as hereinafter defined), the
entire unpaid Principal balance shall become immediately due and payable without further demand or
notice to Borrower. To the extent permitted by law, any of the following events shall be a
“Maturity Event” under this Note and the Deed of Trust:

     (a) Borrower shall fail to pay any amount of the Principal on this Note when due and shall
fail to cure such non-payment within ten (10) days following written notice of such delinquency.

     (b) There shall occur a breach or default in the performance of any obligation of Borrower
contained in this Note, the Deed of Trust, the Employee Loan Agreement executed concurrently
herewith (the “Loan Documents”), or any other agreement now or hereafter entered into by Borrower,
on the one hand, and the Lender, on the other hand, with respect to the Property.

     (c) There shall occur a breach or default in the performance of any obligation of Borrower in
any other deed of trust or other security instrument (whether superior or subordinate in rights to
the Deed of Trust) now or hereafter encumbering the Property.

     (d) Borrower shall sell, convey, encumber, grant any lien upon; or otherwise alienate the
Property, or any part thereof, or any interest therein, or shall be divested of his title or any
interest therein in any manner or way, whether voluntarily or involuntarily, without the written
consent of the Lender being first had and obtained.

     (e) Borrower (i) admits in writing his inability to pay debts, (ii) makes an assignment for
the benefit of creditors, (iii) files a voluntary petition in bankruptcy, effect a plan or other
arrangement with creditors, liquidate his assets under arrangement with

 

 

creditors, or liquidate his assets under court supervision, (iv) has an involuntary petition in
bankruptcy filed against him that is not discharged within sixty (60) days after such petition is
filed, or (v) applies for or permit the appointment of a receiver or trustee or custodian for any
of his property or assets which shall not have been discharged within sixty (60) days after the
date of appointment.

          (f) The Principal shall have become due and payable, upon the happening of certain
events, on such dates as are set forth in Section 2.2 herein.

     (g) Any representation or warranty of Borrower contained herein or in any certificate or
agreement entered into between Borrower for the benefit of Lender in connection herewith shall
prove to be false or misleading in any material respect.

     (h) The Deed of Trust is not recorded against the Property at the closing of the purchase
by Borrower of the Property or at any time ceases to be a valid second priority lien on the
Property.

     (i) Any lien or other monetary encumbrance is imposed against the Property; provided,
however, that in the event that a lien or monetary encumbrance is imposed against the Property
without the consent of Borrower, a Maturity Event shall not occur until the lien or other monetary
encumbrance is imposed against the Property for a period of at least thirty (30) days.

     (j) One (1) year following the death of the Borrower.

     (k) Borrower defaults in his obligation to pay any sum or to perform any obligation,
which is secured by a deed of trust, mortgage, lien, or other encumbrance on the Property (other
than the Deed of Trust).

     (l) The occurrence of any event which causes the Loan and transactions contemplated under
the Loan Documents to be prohibited under Applicable Law, including any prohibition of loans to
officers of public companies under federal or state law.

     5. LATE CHARGE: There shall be no late charge apart from the acceleration of Principal
and the accrual of interest.

     6. BORROWER’S REPRESENTATIONS: Borrower hereby makes the following representations and
warranties to the Lender and acknowledges that Lender is relying on such representations in making
the loan:

     6.1 Borrower shall have good and marketable title to the Property free and clear of any
security interests, liens or encumbrances other than the Deed of Trust in favor of Lender securing
this Note, the first deed of trust in favor of the first priority lien holder and joint ownership
of the property with Borrower’s spouse;

 

 

     6.2 Other than the consent of Borrower’s spouse and the holder of the first priority lien on
the Property, the consent of no other person or entity is required to grant to Lender the security
interest in the Property evidenced by the Deed of Trust;

     6.3 There are no actions, proceedings, claims, or disputes pending or, to the Borrower’s
knowledge, threatened against or affecting Borrower or the Property.

     7. BORROWERS’ ADDITIONAL OBLIGATIONS: Borrower shall take any and all further actions that may
from time to time be required to ensure that the Deed of Trust creates a valid second priority lien
on the Property in favor of the Lender as security for the Note. Borrower shall not further
encumber the Property or permit any lien to encumber the Property. Upon request by Lender, but not
more frequently than once during any calendar year, Borrower shall furnish evidence reasonably
satisfactory to the Lender that: (i) Borrower has good and marketable title to the Property; (ii)
the consent of no other person or entity is required to grant a second priority security interest
in the Property to the Lender; (iii) the Deed of Trust is a second priority security interest in
the Property, and (iv) there are no other deeds of trust, mortgages or encumbrances against the
Property. If it should be hereafter determined that there are defects against title or matters
which could result in defects against title to the Property, or that the consent of another person
or entity is required to grant to and perfect in the Lender a valid second-priority lien on the
Property, Borrower shall promptly take all action necessary to remove such defects and to obtain
such consent and grant (or cause to be granted) and perfect such lien on the Property. Failure of
the Deed of Trust to be a valid second lien against the Property shall be deemed a Maturity Event
as aforesaid.

     8. NOTICE: This Note is subject to Section 2924(i) and 2966 of the California Civil Code which
provides that the holder of this Note shall give written notice to Borrower or his
successors-in-interest, of prescribed information (as set forth in said Civil Code Sections) at
least ninety (90) days and not more than one hundred and fifty (150) days before any balloon
payment is due.

     9. ATTORNEYS’ FEES: In the event of Borrower’s default hereunder, Borrower shall pay all costs
of collection, including reasonable attorneys’ fees incurred by the holder hereof on account of
such collection, whether or not suit is filed hereon.

     10. WAIVER: The waiver by Lender of any breach of or default under any term, covenant or
condition contained herein or in any other agreement referred to above shall not be deemed to be a
waiver of any subsequent breach of or default under the same or any other such term, covenant or
condition.

     11. NO USURY: Borrower hereby represents and warrants that at no time shall the proceeds of
the indebtedness evidenced hereby be used “primarily for personal, family, or household purposes”
as that term is defined and used in Article XV of the California Constitution (as amended from time
to time). Anything in this Note to the

 

 

contrary notwithstanding, it is expressly stipulated and agreed that the intent of Borrower and
Lender are to comply at all times with all usury and other laws relating to this Note. If the laws
of the State of California would now or hereafter render usurious, or are revised, repealed or
judicially interpreted so as to render usurious, any amount called for under this Note, or
contracted for, charged or received with respect to the loan evidenced by this Note, or if any
prepayment by Borrower results in Borrower having paid any interest in excess of that permitted by
law, then it is Borrower’s and Lender’s express intent that all excess amounts theretofore
collected by Lender be credited to the principal balance of this Note (or, if this Note has been
paid in full, refunded to Borrower), and the provisions of this Note immediately be deemed reformed
and the amounts therefor collectible hereunder reduced, without the necessity of execution of any
new document, so as to comply with the then applicable law, but so as to permit the recovery of the
fullest amount otherwise called for hereunder.

     12. PREPAYMENT:
Borrower may prepay all or any portion of this Note at any time prior to the
Maturity Date, with no premium or penalty.

     13. GENERAL PROVISIONS: This Note shall be governed by and construed in accordance with the
laws of the State of California. The makers of this Note hereby waive presentment for payment,
protest and demand, notice of protest, demand and dishonor and nonpayment of this Note, and consent
that Lender may extend the time for payment or otherwise modify the terms of payment or any part of
the whole of the debt evidenced by this Note, at the request of any person liable hereon, and such
consent shall not alter nor diminish the liability of any person. Borrower hereby waives the
defense of the statute of limitations in any action on this Note to the extent permitted by law.
Time is of the essence of this Note, the Deed of Trust and any other document executed by Borrower
in connection therewith. Liability hereunder shall be joint and several among Borrower and all
other persons and entities now or hereafter liable for all or any part of the Loan.

     14. ACKNOWLEDGEMENT BY BORROWER: THIS NOTE, THE LOAN AGREEMENT, THE DEED OF TRUST, AND ALL
RELATED DOCUMENTATION ARE EXECUTED VOLUNTARILY AND WITHOUT ANY DURESS OR UNDUE INFLUENCE ON THE
PART OF OR ON BEHALF OF THE PARTIES HERETO, WITH THE FULL INTENT OF CREATING THE OBLIGATIONS AND
SECURITY INTERESTS DESCRIBED HEREIN AND THEREIN. THE PARTIES ACKNOWLEDGE THAT: (a) THEY HAVE READ
SUCH DOCUMENTATION; (b) THEY HAVE BEEN REPRESENTED IN THE PREPARATION, NEGOTIATION AND EXECUTION OF
SUCH DOCUMENTATION BY LEGAL COUNSEL OF HIS OWN CHOICE; (c) THEY UNDERSTAND THE TERMS AND
CONSEQUENCES OF THIS NOTE, THE LOAN AGREEMENT, THE DEED OF TRUST, AND ALL RELATED AGREEMENTS AND
DOCUMENTATION AND THE OBLIGATIONS THEY CREATE; AND (d) THEY ARE FULLY AWARE OF THE LEGAL AND

 

 

BINDING EFFECT OF THIS NOTE, THE DEED OF TRUST AND THE OTHER DOCUMENTS CONTEMPLATED BY
OR ENTERED INTO IN CONNECTION WITH THIS NOTE.

IN WITNESS WHEREOF, Borrower has executed this Note as of the day and year first above written.

	 	 	 
	/s/ Jeffrey S. Williams
 

Jeffrey S. Williams

	 	 

 

 

LOAN EXTINGUISHMENT AGREEMENT

     THIS LOAN EXTINGUISHMENT AGREEMENT (the “Agreement”) is made and entered into as of December
21, 2005 by and between Jeffrey S. Williams (“Williams”) and Alexza Pharmaceuticals, Inc.
(“Alexza”).

RECITALS

	A.	 	Williams is indebted to Alexza in the aggregate principal amount of $600,000 as evidenced by
a certain promissory notes (the “Notes”).
	 
	B.	 	Subject to the terms and conditions of the Modification Agreement dated as of April 19, 2005,
the Notes are to be repaid by Williams immediately before the filing of a Registration
Statement by Alexza with the Securities and Exchange Commission (the “SEC”), and Alexza has
the option to extinguish the Notes and provide Williams additional funds to pay the related
federal and tax withholding in return for increasing the exercise price of certain options to
purchase the common stock of Alexza (the “Options”).
	 
	C.	 	Subject to the terms and conditions of this Agreement, Alexza extinguishes the Notes and
Williams agrees that a portion of his Options will have their exercise prices increased as set
forth below.
	 
	 	 	THE PARTIES AGREE AS FOLLOWS:
	 
	 	 	1. Extinguishment of Note. Subject to the terms and conditions of this Agreement, Alexza
hereby unconditionally extinguishes and cancels the Notes and releases Williams from all
obligations thereunder and further releases any security interest Alexza has in Williams’
residence at 1382 Via di Salerno, Pleasanton, California. Alexza shall provide $434,483 in
respect of the tax obligations resulting from such extinguishment, which shall be paid to
Williams net of any required withholdings no later than January 15, 2006. Williams shall be
responsible for paying all taxes resulting from the extinguishment of the Notes and the payment
made hereunder.

 

 

2. Modification of Option Exercise Price. Williams agrees that the exercise price of a
number of his Options will be increased to a price equal to (a) the price to public in Alexza’s
initial public offering (“IPO”), (b) if Alexza is sold prior to consummation of an IPO (a “Sale”),
the price per share paid to the holders of Alexza’s common stock in such transaction, or (c) if
neither of the foregoing has occurred prior to June 30, 2006, the fair market value of Alexza’s
common stock as determined by Alexza’s board of directors on such date (the price so determined
being referred to as the “New Exercise Price”). The number of Options to be so repriced shall be
determined by dividing $1,034,483 by the difference between the New Exercise Price and the current
Option exercise price of $0.20, For example, if the price to the public in the IPO is $1.95, the
number of Options to be repriced would be
$1,034,483/($1.95 - $0.20) = 591,133. Any remaining Options held by Williams would continue to
have their current exercise price. If the number of Options to be repriced resulting from the
application of the foregoing formula would exceed the number of Options then held by Williams, all
of Williams’ Options would be repriced to the New Exercise Price and Williams would have no further
obligations to Alexza hereunder. The vesting schedule and other terms of all Options would remain
the same. Williams agrees to deposit with Alexza’s Secretary all option agreements evidencing the
Options and he agrees that he may not exercise any such Options until the New Exercise Price has
been established; provided, however, that in the event of a Sale the Company shall make
arrangements to permit Williams to exercise his Options prior to or concurrently with the closing
of any such transaction.

3. Arbitration. Any and all disputes arising from or related to this Agreement will be
resolved by binding arbitration to be held in Santa Clara County, California pursuant to the rules
and regulations of the American Arbitration Association.

4. Entire Agreement. This Agreement and the Modification Agreement together represent the
entire agreement between the parties relating to the subject matter hereof and supersedes any and
all prior and contemporaneous discussions, understandings, correspondence and agreements. The terms
set forth in this Agreement supersede any contrary provisions contained in the Modification
Agreement.

 

 

     IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above
written.

	 	 	 	 	 	 	 	 	 
	ALEXZA PHARMACEUTICALS, INC.	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	By

	 	/s/ A. J. Moretti
	 	 	 	/s/ Jeffrey S. Williams	 	 
	 

	 	 
	 	 	 	 	 	 
	 

	 	 	 	 	 	Jeffrey S. Williams

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00097-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00097-of-00352.parquet"}]]