Document:

EX-10.41

 Exhibit 10.41 

SECOND AMENDMENT TO LEASE 

This Second Amendment to Lease (this “Amendment”), is made as of the 7th day of April, 2020 (the “Effective
Date”), by and between the BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, acting for the use and benefit of The University of Texas M. D. Anderson Cancer Center, an institution of The University of Texas System
(“Landlord”) and ZIOPHARM ONCOLOGY, INC., a Delaware corporation (“Tenant”). 
 WITNESSETH:

 Reference is hereby made to the following facts: 

A. Landlord and Tenant entered into that certain Lease dated as of October 15, 2019 (the “Existing Lease”), for certain
premises (the “Existing Premises”) known as Suites 8030 and 8032, containing approximately 8,443 rentable square feet in the aggregate, within that certain building known as Building B of the El Rio Buildings, located at 8000 El Rio
Street, Houston, Texas 77054 (as more particularly described in the Existing Lease, the “Building”). Contemporaneously herewith, Landlord and Tenant are entering into a First Amendment to Lease for delivery, installation, use and
maintenance of the Replacement Benches from Landlord to Tenant. All capitalized words and phrases not otherwise defined herein shall have the meanings ascribed to them in the Existing Lease. The Existing Lease, as modified and amended by this
Amendment, is referred to herein as the “Lease”. 
 B. Tenant desires to lease additional premises from Landlord consisting
of (i) approximately 2,770 rentable square feet within the Building, known as Suite 8036, and approximately 2,824 rentable square feet within the Building, known as Suite 8038, all as shown on Exhibit A attached hereto and incorporated
by reference herein (the “Expansion Prime Premises”), and (ii) the generator premises located in the area depicted on Exhibit B-1B attached hereto (the “Expansion Generator
Premises”), the rooftop premises located in the area depicted on Exhibit B-1C attached hereto (the “Expansion Rooftop Premises”), and the gas storage and tank premises located
in the area depicted on Exhibit B-1D attached hereto (the “Expansion Gasses/Tank Premises”, and collectively, the Expansion Prime Premises, the Expansion Generator Premises, the
Expansion Rooftop Premises, and the Expansion Gasses/Tank Premises are the “Expansion Premises”), and Landlord agrees to lease the Expansion Premises to Tenant, and to modify and amend the Existing Lease, all in the manner
hereinafter set forth. 
 NOW THEREFORE, in consideration of Ten Dollars ($10.00) and other good and valuable consideration, the receipt,
sufficiency and delivery of which are hereby acknowledged, the Existing Lease is hereby amended as follows: 
 1. Lease of Expansion
Premises. Landlord hereby leases to Tenant, and Tenant hereby leases from Landlord, the Expansion Premises for a Term commencing on the date (the “Expansion Premises Commencement Date”) on which Landlord delivers the Expansion
Premises to Tenant in the Delivery Condition and expiring on the Expiration Date, unless earlier terminated or extended, in accordance with the terms of the Lease. The lease and use of the Expansion Premises shall be upon and subject to all of the
other terms and conditions of the Existing Lease, except as expressly set forth in this Amendment. The Expansion Premises Commencement Date is anticipated to occur on April 13, 2020 (the “Estimated Expansion Premises Commencement
Date”). The “Expansion Premises Rent Commencement Date” shall mean the earlier to occur of (i) the date on which Tenant has completed Tenant’s Expansion Premises Work (as hereinafter defined), or (ii) the
date that is four (4) months after the Expansion Premises Commencement Date. From and after the Expansion Premises Commencement Date, except as expressly set forth herein, (v) each reference contained in the Existing Lease to the
“Premises” shall be considered to be a reference to the Existing Premises and the Expansion Premises, collectively, (w) each reference contained in the Existing Lease to the “Prime Premises” shall be considered to be a
reference to the existing Prime Premises and the Expansion Prime Premises, collectively, (x) each reference contained in the Existing Lease to the “Generator Premises”, shall be considered to be a reference to the existing Generator
Premises and the Expansion Generator Premises, collectively, (y) each reference contained in the Existing Lease to the “Rooftop Premises”, shall be considered to be a reference to the existing Rooftop Premises and the Expansion
Rooftop Premises, collectively, and (z) each reference contained in the Existing Lease to the “Gasses/Tank Premises”, shall be considered to be a reference to the existing Gasses/Tank Premises and the Expansion Gasses/Tank Premises,
collectively. 

 2. Rent for Expansion Premises. For and with respect to the Expansion Premises,
commencing on the Expansion Premises Rent Commencement Date and continuing through the Expiration Date, Tenant shall pay to Landlord the Base Rent, Tenant’s Share of Taxes, and all other Additional Rent and charges payable pursuant to the Lease
in accordance with the terms and provisions of the Existing Lease, except as set forth herein. 
 a. Commencing on the Expansion Premises
Rent Commencement Date, Tenant shall pay Base Rent with respect to the Expansion Premises as follows: 
  

									
	 Period of Time
	  	Annual Base Rent	 	  	Monthly Payment	 
	 Expansion Premises Lease Year 1
	  	$	138,003.98	 	  	$	11,500.33	 
	 Expansion Premises Lease Year 2
	  	$	138,003.98	 	  	$	11,500.33	 
	 Expansion Premises Lease Year 3
	  	$	142,144.10	 	  	$	11,845.34	 
	 Expansion Premises Lease Year 4
	  	$	146,408.42	 	  	$	12,200.70	 
	 Expansion Premises Lease Year 5
	  	$	150,800.68	 	  	$	12,566.72	 
	 Expansion Premises Lease Year 6
	  	$	155,324.69	 	  	$	12,943.72	 
	 Expansion Premises Lease Year 7
	  	$	159,984.44	 	  	$	13,332.04	 

 For purposes hereof, “Expansion Premises Lease Year” shall mean a twelve-month
period beginning on the Expansion Premises Rent Commencement Date or any anniversary of the Expansion Premises Rent Commencement Date, except that if the Expansion Premises Rent Commencement Date does not fall on the first day of a calendar month,
then the first Expansion Premises Lease Year shall begin on the Expansion Premises Rent Commencement Date and end on the last day of the month containing the first anniversary of the Expansion Premises Rent Commencement Date, and each succeeding
Expansion Premises Lease Year shall begin on the day following the last day of the prior Expansion Premises Lease Year. The final Expansion Premises Lease Year shall end on the Expiration Date. 

  
 -2- 

 b. Without in any way limiting the generality of Section 1 hereof, Tenant’s Share
shall be calculated based upon the rentable area of the existing Prime Premises, as expanded to include the Expansion Prime Premises pursuant to the terms of this Amendment. 

c. Without in any way limiting the generality of Section 1 hereof, Tenant shall be entitled to utilize Remaining Funds to satisfy all
Rent obligations under this Amendment, and for the payment of costs incurred by Tenant in connection with Tenant’s Expansion Premises Work, in each case subject to and in accordance with the terms of the Existing Lease, including, without
limitation, Sections 5.1(b) and Exhibit 3 thereof. 
 3. Expansion Premises Utilities. Without in any way limiting the generality of
Section 1 hereof, electricity and other utilities with respect to the Expansion Premises shall be utilized and paid for by Tenant in accordance with Article 9 of the Existing Lease. 

4. Condition and Delivery of Expansion Premises. 

a. Tenant has inspected the Expansion Premises and agrees (a) to accept possession of, and Landlord agrees to deliver, the Second
Amendment Expansion Premises in the Delivery Condition, and (b) that except as aforesaid, Landlord has no obligation to perform any other work, supply any materials, incur any expense or make any alterations or improvements to prepare the
Expansion Premises for Tenant’s occupancy. In particular, Tenant acknowledges and agrees that Section 3.1 of the Existing Lease applies in its entirety to the Expansion Premises, but Tenant will not have a Termination right as set forth in
Section 3.3 with respect to the Expansion Premises. Any work to be performed by Tenant to the Expansion Premises in connection with Tenant’s initial occupancy of the Expansion Premises shall be hereinafter referred to as
“Tenant’s Expansion Premises Work” and shall be performed in accordance with the terms and conditions of the Existing Lease, including, without limitation, the terms and conditions of Section 11 and Exhibit 3 of the
Existing Lease. Landlord hereby approves of Tenant’s Expansion Premises Work; provided however, in the event Tenant’s Expansion Premises Work (a) is materially inconsistent with the depiction of work attached hereto as Exhibit
C, and (b) requires Landlord’s prior approval in accordance with the terms and conditions of Section 11.1(a) of the Existing Lease, then Tenant shall submit to Landlord for approval a set of Design/ Development Plans, and/or Final
Construction Drawings for Tenant’s Expansion Premises Work in accordance with the terms of Exhibit 3 of the Existing Lease. 

  
 -3- 

 b. Landlord shall use diligent efforts to deliver the Expansion Premises to Tenant in the
Delivery Condition not later than the Estimated Expansion Premises Commencement Date. However, except for Tenant’s remedies set forth in this Section 4(b): (i) Tenant’s sole remedies shall be a delay in the Expansion Premises
Commencement Date, (ii) Tenant shall have no claim or rights against Landlord, and Landlord shall have no liability or obligation to Tenant in the event of delay in the Expansion Premises Commencement Date, and (iii) no delay in the
Expansion Premises Commencement Date shall have any effect on the parties rights or obligations under this Lease. Without limiting the foregoing, as liquidated damages and the sole and exclusive remedies of Tenant on account thereof, (x) if the
Expansion Premises Commencement Date has not occurred by the Estimated Expansion Premises Commencement Date, then for and with respect to each day between the Estimated Expansion Premises Commencement Date and the date on which the Expansion
Premises Commencement Date actually occurs, Tenant shall receive a credit against the Rent payable under the Lease (to be applied to the Rent payable immediately after the Expansion Premises Rent Commencement Date) in an amount equal to the per diem
Base Rent payable for the Expansion Premises, and (y) in addition, if (i) the Expansion Premises Commencement Date has not occurred by the date which is thirty (30) days following the Estimated Expansion Premises Commencement Date
(the “Expansion Premises Cancellation Date”), and (ii) not less than fifteen (15) days prior to the delivery of a Termination Notice (as hereinafter defined) Tenant shall have delivered a Reminder Notice to Landlord (with
applicable changes to conform to this Section 4(b)), then at any time after the Expansion Premises Cancellation Date and prior to the date on which the Expansion Premises Commencement Date actually occurs, Tenant may elect to terminate this
Lease by giving Landlord a Termination Notice, with such termination to be effective immediately upon the giving by Tenant of such Termination Notice. If Tenant timely and validly terminates this Amendment in accordance with the foregoing
provisions, this Amendment shall be null and void and of no further force and effect, and except as expressly and specifically set forth herein, the parties shall have no further liabilities, responsibilities, or obligations hereunder. The Rent
credits set forth above shall be credited against amounts due and payable under this Lease, and in no event will Landlord be required to make any payment to Tenant with respect to any Rent credits that would otherwise be available to Tenant under
this Section 4(b). If the Expansion Premises Commencement Date does not occur prior to the Expansion Premises Cancellation Date, and Tenant does not terminate this Lease in accordance with the foregoing provisions, then Tenant shall continue to
accrue a credit against the Rent payable under this Lease in the amounts set forth above for and with respect to each day between the Estimated Expansion Premises Commencement Date and the date on which the Expansion Premises Commencement Date
actually occurs. 
 5. Parking. From and after the Expansion Premises Commencement Date, the term “Parking Spaces”
shall be amended to provide Tenant with up to fifty-six (56) unreserved parking spaces for Tenant’s use, subject to and in accordance with the terms and conditions of Section 1.3(b) of the
Existing Lease, including, without limitation, the obligation to pay the applicable Parking Charges. 
 6. Existing Lease Commencement
Date. Landlord and Tenant acknowledge and agree that the Commencement Date under the Existing Lease occurred on November 1, 2019. 

7. Brokerage. Tenant warrants and represents to Landlord, and Landlord warrants and represents to Tenant, that it has dealt with no
broker or agent in connection with this Amendment. Tenant agrees to defend, indemnify, and hold Landlord harmless from and against any Claims arising in breach of the representation and warranty set forth in the immediately preceding sentence. 

  
 -4- 

 8. Miscellaneous. Tenant hereby represents and warrants to Landlord as follows:
(i) the execution and delivery of this Amendment by Tenant has been duly authorized by all requisite corporate action; (ii) neither the Existing Lease nor the interest of the Tenant therein has been assigned, sublet, encumbered or
otherwise transferred; (iii) to the actual knowledge of Tenant, there are no defenses or counterclaims to the enforcement of the Existing Lease or the liabilities and obligations of Tenant thereunder; (iv) neither Tenant nor, to the actual
knowledge of Tenant, Landlord, is in breach or default of any of its respective obligations under the Existing Lease, (v) Landlord has made no representations or warranties, except as expressly and specifically set forth in the Existing Lease
and this Amendment. Landlord hereby represents and warrants to Tenant as follows: (i) the execution and delivery of this Amendment by Landlord has been duly authorized by all requisite action; (ii) to the actual knowledge of Landlord,
there are no defenses or counterclaims to the enforcement of the Existing Lease or the liabilities and obligations of Landlord thereunder; (iii) neither Landlord nor, to the actual knowledge of Landlord, Tenant, is in breach or default of any
of its respective obligations under the Existing Lease, and (iv) Tenant has made no representations or warranties, except as expressly and specifically set forth in the Existing Lease and this Amendment. The submission of drafts of this
document for examination and negotiation does not constitute an offer to lease, or a reservation of or option for, the Expansion Premises, and this Amendment shall not be binding upon Landlord or Tenant unless and until Landlord has executed and
delivered to Tenant a fully-executed version of this Amendment. Except as expressly and specifically set forth in this Amendment, the Existing Lease is hereby ratified and confirmed, and all of the terms, covenants, agreements and provisions of the
Existing Lease shall remain unaltered and unmodified and in full force and effect throughout the balance of the Term of the Lease. 
 9.
Counterparts. This Amendment may be executed in any number of counterparts and by each of the undersigned on separate counterparts, which counterparts taken together shall constitute one and the same instrument. This Amendment may be executed
by electronic signature, which shall be considered as an original signature for all purposes and shall have the same force and effect as an original signature. Without limitation, in addition to electronically produced signatures, “electronic
signature” shall include faxed versions of an original signature or electronically scanned and transmitted versions (e.g., via pdf) of an original signature. 

[Signature Page Follows] 

  
 -5- 

 EXECUTED as an instrument under seal as of the date first above-written. 

 

			
	LANDLORD
	
	BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, for the use and benefit of The University of Texas M. D. Anderson Cancer Center
		
	By:	 	 /s/ Ben Melson

	Name:	 	Ben Melson
	Title:	 	Senior Vice President and Chief Financial Officer

  

			
	Approved as to Content:
	
	THE UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER
		
	By:	 	 /s/ Spencer Moore

	Name:	 	 Spencer Moore

	Title:	 	 VP and Chief Facilities Officer

  

					
	             
	 	 Reviewed and Approved by

		 	 UTMDACC Legal Services for

		 	 UTMDACC Signature:

		 	 /s/ Chad Mavity         4/9/2020

			
	TENANT
	
	ZIOPHARM ONCOLOGY, INC.,
	a Delaware limited liability company
		
	By:	 	 /s/ Kevin G. Lafond

	Name:	 	 Kevin G. Lafond

	Title:	 	 Chief Accounting Officer

 EXHIBIT A 

Floor Plan for Expansion Premises - 8036 
  

 

  
 B-1B 

 EXHIBIT A 

Floor Plan for Expansion Premises - 8038 
  

 

  
 B-2 -2- 

 EXHIBIT B-1B 

Expansion Generator Premises 

  
 B-2 -3- 

 EXHIBIT B-1C 

Expansion Rooftop Premises 

  
 B-1C 

 EXHIBIT B-1D 

Expansion Gasses/Tank Premises 

  
 B-1D 

 EXHIBIT C 

Fit Plan of Tenant’s Expansion Premises Work 

  
 C-1EX-10.42

 Exhibit 10.42 

THIRD AMENDMENT TO LEASE 

This Third Amendment to Lease (this “Amendment”), is made as of the 15th day of December, 2020 (the “Effective
Date”), by and between the BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, acting for the use and benefit of The University of Texas M. D. Anderson Cancer Center, an institution of The University of Texas System
(“Landlord”) and ZIOPHARM ONCOLOGY, INC., a Delaware corporation (“Tenant”). 
 WITNESSETH:

 Reference is hereby made to the following facts: 

A. Landlord and Tenant entered into that certain Lease (as heretofore amended, the “Existing Lease”) dated as of
October 15, 2019 (the “Original Lease”), as amended by that certain First Amendment to Lease dated as of April 7, 2020, and that certain Second Amendment to Lease dated as of April 7, 2020, for certain premises (the
“Premises”) known as Suites 8030, 8032, 8036 and 8038, containing approximately 14,037 rentable square feet in the aggregate, within that certain building known as Building B of the El Rio Buildings, located at 8000 El Rio Street,
Houston, Texas 77054 (as more particularly described in the Existing Lease, the “Building”). All capitalized words and phrases not otherwise defined herein shall have the meanings ascribed to them in the Existing Lease. The Existing
Lease, as modified and amended by this Amendment, is referred to herein as the “Lease”. 
 B. Landlord and Tenant have
agreed to modify and amend the Existing Lease, all in the manner hereinafter set forth. 
 NOW THEREFORE, in consideration of Ten Dollars
($10.00) and other good and valuable consideration, the receipt, sufficiency and delivery of which are hereby acknowledged, the Existing Lease is hereby amended as follows: 

1. Rent Commencement Date; Expiration Date. Landlord and Tenant acknowledge and agree that (i) the Rent Commencement Date occurred
on March 1, 2020, (ii) the Expansion Premises Commencement Date occurred on April 13, 2020, (iii) the Expansion Premises Rent Commencement Date occurred on August 13, 2020; and (iv) the Expiration Date is February 28, 2027.

 2. Definition of Rent Year. The definition of “Rent Year” set forth in the Lease Summary Sheet of the Original Lease is
hereby deleted in its entirety and replaced with the following: 
 “A twelve (12) month period beginning on the Rent Commencement
Date or any anniversary of the Rent Commencement Date, except that if the Rent Commencement Date does not fall on the first day of a calendar month, then the first Rent Year shall begin on the Rent Commencement Date and end on the last day of the
month containing the first anniversary of the Rent Commencement Date, and each succeeding Rent Year shall begin on the day following the last day of the prior Rent Year; provided that the last Rent Year shall end on the Expiration Date.” 

 3. Definition of Tenant’s Share. The definition of “Tenant’s
Share” set forth in the Lease Summary Sheet of the Original Lease is hereby deleted in its entirety and replaced with the following: 
 “A
fraction, the numerator of which is the number of rentable square feet in the Prime Premises and the denominator of which is the number of rentable square feet in the Campus that is not exempt from taxation by the relevant taxing authority. As of
the Effective Date of the Third Amendment to this Lease, Tenant’s Share is 30.52%.” 
 4. Taxes. 

(a) Section 5.3(a) of the Original Lease is hereby deleted in its entirety and replaced with the following: 

“(a) Landlord is an agency of the state of Texas. As such, Landlord does not pay real estate taxes or personal property taxes on property
used and controlled by Landlord. Such exemption does not apply to the Premises when under the use and control of Tenant. “Taxes” shall mean the real estate taxes and other taxes, levies and assessments imposed upon the Campus and
upon any personal property of Landlord used in the operation thereof, or on Landlord’s interest therein or such personal property; charges, fees and assessments for transit, housing, police, fire or other services or purported benefits to the
Campus (including without limitation any community preservation assessments); service or user payments in lieu of taxes; and any and all other taxes, levies, betterments, assessments and charges arising from the ownership, leasing, operation, use or
occupancy of the Campus or based upon rentals derived therefrom, which are or shall be imposed by federal, state, county, municipal or other governmental authorities. Taxes shall not include any sales, inheritance, estate, succession, gift,
franchise, rental, income or profit tax, capital stock tax, capital levy or excise, any income taxes arising out of or related to the ownership and operation of the Campus, or any interest or penalties resulting from the late payment of Taxes by
Landlord (except to the extent due to Tenant’s failure to make timely payments); provided, however, that if during the Term the present system of taxation of real or personal property shall be changed, any tax, excise, fee, levy, charge or
assessment, however described, that may in the future be levied or assessed as a substitute for, in whole or in part, any tax, levy or assessment which would otherwise constitute Taxes, whether or not now customary or in the contemplation of the
parties on the Execution Date of this Lease, shall constitute Taxes, but only to the extent calculated as if the Campus were the only real estate owned by Landlord. “Taxes” shall also include reasonable expenses (including without
limitation legal and consultant fees) of tax abatement or other proceedings contesting assessments or levies.” 
 (b) Section 5.3(e) of
the Original Lease is hereby deleted in its entirety and replaced with the following: 
 “(e) Part Years. Tenant shall be
responsible for the payment of Tenant’s Share of Taxes for and with respect to the period of time commencing on the Commencement Date and ending on the last day of the Tax Period in which the Expiration Date or earlier termination of this Lease
occurs.” 

  
 -2- 

 (c) Notwithstanding any provision of the Existing Lease to the contrary, Tenant’s
monthly payments of Tenant’s Share of Taxes shall commence on (i) the Commencement Date, with respect to the Premises demised under the Original Lease, and (ii) the Expansion Premises Commencement Date, with respect to the Expansion
Premises. 
 5. Gas. Section 9.3 of the Original Lease is hereby deleted in its entirety and replaced with the following: 

“Gas. Tenant shall contract with the applicable utility provider for gas service to the Premises, and shall pay all charges for gas furnished by
the utility provider to the Premises, all at Tenant’s sole cost and expense.” 
 6. Premises Cleaning. Section 10.5 of
the Original Lease is hereby deleted in its entirety and replaced with the following: 
 “Premises Cleaning. Tenant shall be responsible, at its
sole cost and expense, for janitorial and removing trash from the Premises to Tenant’s dumpster, and for providing biohazard disposal services for the Premises, including the laboratory areas thereof. Such services shall be performed by
licensed (where required by law or governmental regulation), insured and qualified contractors and on a sufficient basis to ensure that the Premises are at all times kept neat and clean. Tenant shall maintain a dumpster and/or compactor on the
Campus within a reasonable proximity to the Building for Tenant’s disposal of non-hazardous and non-controlled substances, the location of which shall be approved
by Landlord, such approval not to be unreasonably withheld, conditioned or delayed.” 
 7. Force Majeure. Section 26.14 of
the Original Lease is hereby deleted in its entirety and replaced with the following: 
 “26.14 Force Majeure. Other than for obligations
under this Lease that can be performed by the payment of money (e.g., payment of Rent and maintenance of insurance), whenever a period of time is herein prescribed for action to be taken by either party hereto, such party shall not be liable or
responsible for, and there shall be excluded from the computation of any such period of time, any delays due to strikes, riots, acts of God, shortages of labor or materials, war, acts of terrorism, national or regional emergency, or a pandemic,
epidemic or other public health emergency or exigency, governmental laws, regulations, or restrictions, or any other causes of any kind whatsoever which are beyond the control of such party (collectively “Force Majeure”). In no
event (i) shall financial inability of a party be deemed to be Force Majeure, and (ii) shall Force Majeure postpone or delay any of Tenant’s remedies set forth in Section 3.2.” 

8. Landlord’s Services. Exhibit 4 to the Original Lease is hereby amended by deleting the following: 

“4. Trash disposal from the common dumpster serving the Building for disposal of non-hazardous
and non-controlled substances.” 
 9. Brokerage. Tenant warrants and represents to
Landlord, and Landlord warrants and represents to Tenant, that it has dealt with no broker or agent in connection with this Amendment. Tenant agrees to defend, indemnify, and hold Landlord harmless from and against any Claims arising as a result of
Tenant’s breach of the representation and warranty set forth in the immediately preceding sentence. 

  
 -3- 

 10. Tenant hereby represents and warrants to Landlord as follows: (i) the
execution and delivery of this Amendment by Tenant has been duly authorized by all requisite corporate action; (ii) neither the Existing Lease nor the interest of the Tenant therein has been assigned, sublet, encumbered or otherwise
transferred; (iii) to the actual knowledge of Tenant, there are no defenses or counterclaims to the enforcement of the Existing Lease or the liabilities and obligations of Tenant thereunder; (iv) neither Tenant nor, to the actual knowledge
of Tenant, Landlord, is in breach or default of any of its respective obligations under the Existing Lease, (v) Landlord has made no representations or warranties, except as expressly and specifically set forth in the Existing Lease and this
Amendment. Landlord hereby represents and warrants to Tenant as follows: (i) the execution and delivery of this Amendment by Landlord has been duly authorized by all requisite action; (ii) to the actual knowledge of Landlord, there are no
defenses or counterclaims to the enforcement of the Existing Lease or the liabilities and obligations of Landlord thereunder; (iii) neither Landlord nor, to the actual knowledge of Landlord, Tenant, is in breach or default of any of its
respective obligations under the Existing Lease, and (iv) Tenant has made no representations or warranties, except as expressly and specifically set forth in the Existing Lease and this Amendment. This Amendment shall not be binding upon
Landlord or Tenant unless and until Landlord has executed and delivered to Tenant a fully-executed version of this Amendment. Except as expressly and specifically set forth in this Amendment, the Existing Lease is hereby ratified and confirmed, and
all of the terms, covenants, agreements and provisions of the Existing Lease shall remain unaltered and unmodified and in full force and effect throughout the balance of the Term of the Lease. 

11. Counterparts. This Amendment may be executed in any number of counterparts and by each of the undersigned on separate counterparts,
which counterparts taken together shall constitute one and the same instrument. This Amendment may be executed by electronic signature, which shall be considered as an original signature for all purposes and shall have the same force and effect as
an original signature. Without limitation, in addition to electronically produced signatures, “electronic signature” shall include faxed versions of an original signature or electronically scanned and transmitted versions (e.g., via pdf)
of an original signature. 
 [Signature Page Follows] 

  
 -4- 

 EXECUTED as an instrument under seal as of the date first above-written. 

 

			
	LANDLORD
	
	BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, for the use and benefit of The University of Texas M. D. Anderson Cancer Center
		
	By:	 	 /s/ Ben Melson

	Name:	 	Ben Melson
	Title:	 	Senior Vice President and Chief Financial Officer

 Approved as to Content: 
  

					
	THE UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER
			
		 	By:	 	 /s/ Spencer Moore

		 	Name:	 	Spencer Moore
		 	Title:	 	Vice President and Chief Facilities Officer

			
		
		 	 Reviewed and Approved by

		 	 UTMDACC Legal Services for

		 	UTMDACC Signature:
		 	 /s/ Chad Mavity     12/15/2020

			
	 TENANT

	
	 ZIOPHARM ONCOLOGY, INC.,

	 a Delaware limited liability company

		
	By:	 	 /s/ Kevin Lafond

	Name:	 	 Kevin Lafond

	Title:	 	 Chief Accounting Officer

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