Document:

Form of Incentive Stock Option Agreement

 Exhibit 10.2.3 
 INCENTIVE STOCK OPTION AGREEMENT 
 PARATEK
PHARMACEUTICALS, INC. 
 AGREEMENT made as of the      day of
                , 2006 (the “Effective Date”), between PARATEK PHARMACEUTICALS, INC. (the “Company”), a Delaware corporation having a principal place
of business in the Commonwealth of Massachusetts, and                     , an employee of the Company (the “Employee”). 

WHEREAS, the Company desires to grant to the Employee an Option to purchase shares of its common stock, $.001 par value per share (the
“Shares”), under and for the purposes set forth in the Company’s 2005 Employee, Director and Consultant Stock Plan, as amended (the “Plan”); 
 WHEREAS, the Company and the Employee understand and agree that any terms used and not defined herein have the same meanings as in the Plan; and 

WHEREAS, the Company and the Employee each intend that the Option granted herein qualify as an ISO. 

NOW, THEREFORE, in consideration of the mutual covenants hereinafter set forth and for other good and valuable consideration, the parties
hereto agree as follows: 
  

	 	1.	GRANT OF OPTION. 

 The
Company hereby grants to the Employee the right and option to purchase all or any part of an aggregate of                     
(                ) Shares, on the terms and conditions and subject to all the limitations set forth herein, under United States securities and tax laws, and in the Plan,
which is incorporated herein by reference. The Employee acknowledges receipt of a copy of the Plan. 
  

	 	2.	PURCHASE PRICE. 

 The
purchase price of the Shares covered by the Option shall be      cents ($                ) per Share, subject to adjustment, as provided in the
Plan, in the event of a stock split, reverse stock split or other events affecting the holders of Shares after the date hereof (the “Purchase Price”). Payment shall be made in accordance with Paragraph 9 of the Plan. 

 

	 	3.	EXERCISABILITY OF OPTION. 

Subject to the terms and conditions set forth in this Agreement and the Plan, the Option granted hereby shall become exercisable as
follows: 
  

			
	On                     ,	  	Up to 25% of the Shares

			
	 At the end of each three-month

period following
	  	  
 an additional 6.25% of the Shares

 Alternatively, at the election of the Employee, the Option may be exercised in whole or in part at any
time as to the Shares which have not yet vested (“Unvested Shares”) in accordance with the above schedule; provided, however, that as a condition to exercising the Option for such Unvested Shares, the Employee shall execute a
Restricted Stock Agreement in the form attached hereto as Exhibit B. 
 The foregoing rights are cumulative and are
subject to the other terms and conditions of this Agreement and the Plan. 
  

	 	4.	TERM OF OPTION. 

 The
Option shall terminate ten (10) years from the date of this Agreement or, if the Employee owns as of the date hereof more than ten percent (10%) of the total combined voting power of all classes of capital stock of the Company or an
Affiliate, five (5) years from the date of this Agreement, but shall be subject to earlier termination as provided herein or in the Plan. 
 If the Employee ceases to be an employee of the Company or of an Affiliate (for any reason other than the death or Disability of the Employee or termination of the Employee’s employment for
“cause” (as defined in the Plan), the Option may be exercised, if it has not previously terminated, within three (3) months after the date the Employee ceases to be an employee of the Company or an Affiliate, or within the originally
prescribed term of the Option, whichever is earlier, but may not be exercised thereafter except as set forth below. In such event, the Option shall be exercisable only to the extent that the Option has become exercisable as set forth above
and is in effect at the date of such cessation of employment. 
 If the Employee ceases to be an employee of the Company or of
an Affiliate but continues after termination of employment to provide service to the Company or an Affiliate as a consultant, this Option shall continue to vest in accordance with Section 3 above as if this Option had not terminated until the
Employee is no longer providing services to the Company. In such case, this Option shall automatically convert and be deemed a Non-Qualified Option as of the date that is three months from termination of the Employee’s employment and this
Option shall continue on the same terms and conditions set forth herein until such Employee is no longer providing service to the Company or an Affiliate. 
 Notwithstanding the foregoing, in the event of the Employee’s Disability or death within three (3) months after the termination of employment, the Employee or the Employee’s Survivors may
exercise the Option within one (1) year after the date of the Employee’s termination of employment, but in no event after the date of expiration of the term of the Option. 

In the event the Employee’s employment is terminated by the Employee’s employer for “cause”, (as defined in the
Plan), the Employee’s right to exercise any unexercised portion of its Option shall cease immediately as of the time the Employee is notified his or her employment is 

  
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terminated for “cause”, and this Option shall thereupon terminate. Notwithstanding anything herein to the contrary, if subsequent to the Employee’s termination as an employee, but
prior to the exercise of the Option, the Board of Directors of the Company determines that, either prior or subsequent to the Employee’s termination, the Employee engaged in conduct which would constitute “cause”, then the Employee
shall immediately cease to have any right to exercise the Option and this Option shall thereupon terminate. 
 In the event of
the Disability of the Employee, as determined in accordance with the Plan, the Option shall be exercisable within one (1) year after the Employee’s termination of employment or, if earlier, within the term originally prescribed by the
Option. In such event, the Option shall be exercisable: 
  

	 	(a)	to the extent that the Option has become exercisable but has not been exercised as of the date of Disability; and 

 

	 	(b)	in the event rights to exercise the Option accrue periodically, to the extent of a pro rata portion through the date of Disability of any additional vesting rights as
that would have accrued on the next vesting date had the Employee not become Disabled. The proration shall be based upon the number of days accrued in the current vesting period prior to the date of Disability. 

In the event of the death of the Employee while an employee of the Company or of an Affiliate, the Option shall be exercisable by the
Employee’s Survivors within one (1) year after the date of death of the Employee or, if earlier, within the originally prescribed term of the Option. In such event, the Option shall be exercisable: 

 

	 	(x)	to the extent that the Option has become exercisable but has not been exercised as of the date of death; and 

 

	 	(y)	in the event rights to exercise the Option accrue periodically, to the extent of a pro rata portion through the date of death of any additional vesting rights that
would have accrued on the next vesting date had the Employee not died. The proration shall be based upon the number of days accrued in the current vesting period prior to the Employee’s date of death. 

 

	 	5.	METHOD OF EXERCISING OPTION. 

 Subject to the terms and conditions of this Agreement, the Option may be exercised by written notice to the Company or its designee, in substantially the form of Exhibit A attached hereto.
Such notice shall state the number of Shares with respect to which the Option is being exercised and shall be signed by the person exercising the Option. Payment of the purchase price for such Shares shall be made in accordance with Paragraph 9 of
the Plan. The Company shall deliver such Shares as soon as practicable after the notice shall be received, provided, however, that the Company may delay issuance of such Shares until completion of any action or obtaining of any consent, which the
Company deems necessary under any applicable law (including, without limitation, state securities or “blue sky” laws). The Shares as to which the 

  
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Option shall have been so exercised shall be registered in the Company’s share register in the name of the person so exercising the Option (or, if the Option shall be exercised by the
Employee and if the Employee shall so request in the notice exercising the Option, shall be registered in the name of the Employee and another person jointly, with right of survivorship) and shall be delivered as provided above to or upon the
written order of the person exercising the Option. In the event the Option shall be exercised, pursuant to Section 4 hereof, by any person other than the Employee, such notice shall be accompanied by appropriate proof of the right of such
person to exercise the Option. All Shares that shall be purchased upon the exercise of the Option as provided herein shall be fully paid and nonassessable. 
  

	 	6.	PARTIAL EXERCISE. 

Exercise of this Option to the extent above stated may be made in part at any time and from time to time within the above limits, except
that no fractional share shall be issued pursuant to this Option. 
  

	 	7.	NON-ASSIGNABILITY. 

 The
Option shall not be transferable by the Employee otherwise than by will or by the laws of descent and distribution. The Option shall be exercisable, during the Employee’s lifetime, only by the Employee (or, in the event of legal incapacity or
incompetency, by the Employee’s guardian or representative) and shall not be assigned, pledged or hypothecated in any way (whether by operation of law or otherwise) and shall not be subject to execution, attachment or similar process. Any
attempted transfer, assignment, pledge, hypothecation or other disposition of the Option or of any rights granted hereunder contrary to the provisions of this Section 7, or the levy of any attachment or similar process upon the Option shall be
null and void. 
  

	 	8.	NO RIGHTS AS STOCKHOLDER UNTIL EXERCISE. 

 The Employee shall have no rights as a stockholder with respect to Shares subject to this Agreement until registration of the Shares in the Company’s share register in the name of the Employee.
Except as is expressly provided in the Plan with respect to certain changes in the capitalization of the Company, no adjustment shall be made for dividends or similar rights for which the record date is prior to the date of such registration.

  

	 	9.	ADJUSTMENTS. 

 The Plan
contains provisions covering the treatment of Options in a number of contingencies such as stock splits and mergers. Provisions in the Plan for adjustment with respect to stock subject to Options and the related provisions with respect to successors
to the business of the Company are hereby made applicable hereunder and are incorporated herein by reference. 

  
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	 	10.	TAXES. 

 The Employee
acknowledges that any income or other taxes due from him or her with respect to this Option or the Shares issuable pursuant to this Option shall be the Employee’s responsibility. The Employee acknowledges and agrees that (i) the Employee
was free to use professional advisors of his or her choice in connection with this Agreement, has received advice from his or her professional advisors in connection with this Agreement, understands its meaning and import, and is entering into this
Agreement freely and without coercion or duress; (ii) the Employee has not received and is not relying upon any advice, representations or assurances made by or on behalf of the Company or any Affiliate or any employee of or counsel to the
Company or any Affiliate regarding any tax or other effects or implications of the Option, the Shares or other matters contemplated by this Agreement and (iii) neither the Company its Affiliates, nor any of its officers or directors, shall be
held liable for any applicable costs, taxes, or penalties associated with the Option if, in fact, the Internal Revenue Service were to determine that the Options constitutes deferred compensation under Section 409A of the Code. 

In the event of a Disqualifying Disposition (as defined in Section 15 below) or if the Option is converted into a Non-Qualified
Option and such Non-Qualified Option is exercised, the Company may withhold from the Employee’s remuneration, if any, the minimum statutory amount of federal, state and local withholding taxes attributable to such amount that is considered
compensation includable in such person’s gross income. At the Company’s discretion, the amount required to be withheld may be withheld in cash from such remuneration, or in kind from the Shares otherwise deliverable to the Employee on
exercise of the Option. The Employee further agrees that, if the Company does not withhold an amount from the Employee’s remuneration sufficient to satisfy the Company’s income tax withholding obligation, the Employee will reimburse the
Company on demand, in cash, for the amount under-withheld. 
  

	 	11.	PURCHASE FOR INVESTMENT. 

Unless the offering and sale of the Shares to be issued upon the particular exercise of the Option shall have been effectively registered
under the Securities Act of 1933, as now in force or hereafter amended (the “1933 Act”), the Company shall be under no obligation to issue the Shares covered by such exercise unless and until the following conditions have been fulfilled:

  

	 	(a)	The person(s) who exercise the Option shall warrant to the Company, at the time of such exercise, that such person(s) are acquiring such Shares for their own respective
accounts, for investment, and not with a view to, or for sale in connection with, the distribution of any such Shares, in which event the person(s) acquiring such Shares shall be bound by the provisions of the following legend which shall be
endorsed upon any certificate(s) evidencing the Shares issued pursuant to such exercise: 

 “The shares
represented by this certificate have been taken for investment and they may not be sold or otherwise transferred by any person, including a pledgee, unless (1) either (a) a Registration Statement with respect to such shares shall be
effective under the Securities Act of 1933, as 

  
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amended, or (b) the Company shall have received an opinion of counsel satisfactory to it that an exemption from registration under such Act is then available, and (2) there shall have
been compliance with all applicable state securities laws”; and 
  

	 	(b)	If the Company so requires, the Company shall have received an opinion of its counsel that the Shares may be issued upon such particular exercise in compliance with the
1933 Act without registration thereunder. Without limiting the generality of the foregoing, the Company may delay issuance of the Shares until completion of any action or obtaining of any consent, which the Company deems necessary under any
applicable law (including without limitation state securities or “blue sky” laws). 

  

	 	12.	RESTRICTIONS ON TRANSFER OF SHARES. 

 12.1 The Shares acquired by the Employee pursuant to the exercise of the Option granted hereby shall not be transferred by the Employee except as permitted herein. 

12.2 In the event of the Employee’s termination of employment or for any reason, the Company shall have the option, but not the
obligation, to repurchase all or any part of the Shares issued pursuant to this Agreement (including, without limitation, Shares purchased after termination of employment, Disability or death in accordance with Section 4 hereof). In the event
the Company does not, upon the termination of employment of the Employee (as described above), exercise its option pursuant to this Section 12.2, the restrictions set forth in the balance of this Agreement shall not thereby lapse, and the
Employee for himself or herself, his or her heirs, legatees, executors, administrators and other successors in interest, agrees that the Shares shall remain subject to such restrictions. The following provisions shall apply to a repurchase under
this Section 12.2; 
 (i) The per share repurchase price of the Shares to be sold to the Company upon exercise of its
option under this Section 12.2 shall be equal to the Fair Market Value of each such Share determined in accordance with the Plan as of the date of termination of employment; provided, however, in the event of a termination by the Company for
“cause” (as defined in the Plan), the per share repurchase price of the Shares to be sold to the Company upon exercise of its option under this Section 12.2 shall be equal to the Purchase Price. 

(ii) The Company’s option to repurchase the Employee’s Shares in the event of termination of employment, death or Disability
shall be valid for a period of six (6) months commencing with the date of such termination, death or Disability. 
 (iii)
In the event the Company shall be entitled to and shall elect to exercise its option to repurchase the Employee’s Shares under this Section 12.2, the Company shall notify the Employee, or in case of death, his or her Survivor, in writing
of its intent to repurchase the Shares. Such written notice may be mailed by the Company up to and including the last day of the time period provided for in Section 12.2(ii) for exercise of the Company’s option to repurchase. 

  
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 (iv) The written notice to the Employee shall specify the address at, and the time and date
on, which payment of the repurchase price is to be made (the “Closing”). The date specified shall not be less than ten (10) days nor more than sixty (60) days from the date of the mailing of the notice, and the Employee or his or
her successor in interest with respect to the Shares shall have no further rights as the owner thereof from and after the date specified in the notice. At the Closing, the repurchase price shall be delivered to the Employee or his or her successor
in interest and the Shares being purchased, duly endorsed for transfer, shall, to the extent that they are not then in the possession of the Company, be delivered to the Company by the Employee or his or her successor in interest. 

12.3 It shall be a condition precedent to the validity of any sale or other transfer of any Shares by the Employee that the following
restrictions be complied with (except as hereinafter otherwise provided): 
  

	 	(i)	No Shares owned by the Employee may be sold, pledged or otherwise transferred (including by gift or devise) to any person or entity, voluntarily, or by operation of
law, except in accordance with the terms and conditions hereinafter set forth. 

  

	 	(ii)	Before selling or otherwise transferring all or part of the Shares, the Employee shall give written notice of such intention to the Company, which notice shall include
the name of the proposed transferee, the proposed purchase price per share, the terms of payment of such purchase price and all other matters relating to such sale or transfer and shall be accompanied by a copy of the binding written agreement of
the proposed transferee to purchase the Shares of the Employee. Such notice shall constitute a binding offer by the Employee to sell to the Company such number of the Shares then held by the Employee as are proposed to be sold in the notice at the
monetary price per share designated in such notice, payable on the terms offered to the Employee by the proposed transferee (provided, however, that the Company shall not be required to meet any non-monetary terms of the proposed transfer,
including, without limitation, delivery of other securities in exchange for the Shares proposed to be sold). The Company shall give written notice to the Employee as to whether such offer has been accepted in whole by the Company within sixty
(60) days after its receipt of written notice from the Employee. The Company may only accept such offer in whole and may not accept such offer in part. Such acceptance notice shall fix a time, location and date for the Closing on such purchase
(“Closing Date”) which shall not be less than ten (10) nor more than sixty (60) days after the giving of the acceptance notice provided, however, if any of the Shares to be sold pursuant to this Section 12.3 have been held
by the Employee for less than six months, then the Closing Date may be extended by the Company until no more than ten days after such Shares have been held by the Employee for six months if required under applicable accounting rules in effect at the
time. At such closing, the Employee shall accept payment as set forth herein and shall deliver to the Company in exchange therefor certificates for the number of Shares stated in the notice accompanied by duly executed instruments of transfer.

  
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	 	(iii)	If the Company shall fail to accept any such offer, the Employee shall be free to sell all, but not less than all, of the Shares set forth in his or her notice to the
designated transferee at the price and terms designated in the Employee’s notice, provided that (i) such sale is consummated within six (6) months after the giving of notice by the Employee to the Company as aforesaid, and
(ii) the transferee first agrees in writing to be bound by the provisions of this Section 12 so that such transferee (and all subsequent transferees) shall thereafter only be permitted to sell or transfer the Shares in accordance with the
terms hereof. After the expiration of such six (6) months, the provisions of this Section 12.3 shall again apply with respect to any proposed voluntary transfer of the Employee’s Shares. 

 

	 	(iv)	The restrictions on transfer contained in this Section 12.3 shall not apply to transfers by the Employee (a) to the trustee or trustees of a trust revocable
solely by him or her, (b) to one or more members of his or her Immediate Family, (c) to a trust for the benefit of himself or herself and/or one or more members of his or her Immediate Family, (d) to a partnership all of the partners
of which are him or her and/or a Permitted Transferee of the type described in clauses (a) through (e) of this clause (iv), (e) to a limited liability company or similar entity all of the members of which are him or her and/or a
Permitted Transferee of the type described in clauses (a) through (e) of this clause (iv), (f) as a bona fide gift or donation to a charitable organization, (g) to his or her guardian or conservator, or (h) in the
event of his or her death, to his or her executor(s) or administrator(s) or to trustee(s) under his or her will (collectively, “Permitted Transferees”); provided that in any such event the Shares so transferred in the hands of each
such Permitted Transferee shall remain subject to this Agreement (including the Company’s rights under Section 12.1), and each such Permitted Transferee shall so acknowledge in writing as a condition precedent to the effectiveness of such
transfer.” As used herein, the term “Immediate Family Member” shall mean the Employee’s spouse or equivalent, former spouse, parents, children, stepchildren, adoptive relationships, sisters, brothers, nieces, nephews and
grandchildren. 

  

	 	(v)	The provisions of this Section 12.3 may be waived by the Company. Any such waiver may be unconditional or based upon such conditions as the Company may impose.

 12.4 In the event that the Employee or his or her successor in interest fails to deliver the Shares to be
repurchased by the Company under this Agreement, the Company may elect (a) to establish a segregated account in the amount of the repurchase price, such account to be turned over to the Employee or his or her successor in interest upon delivery
of such Shares, and (b) immediately to take such action as is appropriate to transfer record title of such Shares from the Employee to the Company and to treat the Employee and such Shares in all respects as if delivery of such Shares had been
made as required by this Agreement. The Employee hereby irrevocably grants the Company a power of attorney which shall be coupled with an interest for the purpose of effectuating the preceding sentence. 

  
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 12.5 If the Company shall pay a stock dividend or declare a stock split on or with respect
to any of its Common Stock, or otherwise distribute securities of the Company to the holders of its Common Stock, the number of shares of stock or other securities of the Company issued with respect to the shares then subject to the restrictions
contained in this Agreement shall be added to the Shares subject to the Company’s rights to repurchase pursuant to this Agreement. If the Company shall distribute to its stockholders shares of stock of another corporation, the shares of stock
of such other corporation, distributed with respect to the Shares then subject to the restrictions contained in this Agreement, shall be added to the Shares subject to the Company’s rights to repurchase pursuant to this Agreement. 

12.6 If the outstanding shares of Common Stock of the Company shall be subdivided into a greater number of shares or combined into a
smaller number of shares, or in the event of a reclassification of the outstanding shares of Common Stock of the Company, or if the Company shall be a party to a merger, consolidation or capital reorganization, there shall be substituted for the
Shares then subject to the restrictions contained in this Agreement such amount and kind of securities as are issued in such subdivision, combination, reclassification, merger, consolidation or capital reorganization in respect of the Shares subject
immediately prior thereto to the Company’s rights to repurchase pursuant to this Agreement. 
 12.7 The Company shall not
be required to transfer any Shares on its books which shall have been sold, assigned or otherwise transferred in violation of this Agreement, or to treat as owner of such Shares, or to accord the right to vote as such owner or to pay dividends to,
any person or organization to which any such Shares shall have been so sold, assigned or otherwise transferred, in violation of this Agreement. 
 12.8 The provisions of Sections 12.1, 12.2 and 12.3 shall terminate upon the effective date of the registration of the Shares pursuant to the Securities Exchange Act of 1934. 

12.9 The Employee agrees that in the event the Company proposes to offer for sale to the public any of its equity securities and such
Employee is requested by the Company and any underwriter engaged by the Company in connection with such offering to sign an agreement restricting the sale or other transfer of Shares, then it will promptly sign such agreement and will not transfer,
whether in privately negotiated transactions or to the public in open market transactions or otherwise, any Shares or other securities of the Company held by him or her during such period as is determined by the Company and the underwriters, not to
exceed 180 days following the closing of the offering, plus such additional period of time as may be required to comply with Marketplace Rule 2711 of the National Association of Securities Dealers, Inc. or similar rules thereto (such period, the
“Lock-Up Period”). Such agreement shall be in writing and in form and substance reasonably satisfactory to the Company and such underwriter and pursuant to customary and prevailing terms and conditions. Notwithstanding whether the Employee
has signed such an agreement, the Company may impose stop-transfer instructions with respect to the Shares or other securities of the Company subject to the foregoing restrictions until the end of the Lock-Up Period. 

12.10 The Employee acknowledges and agrees that neither the Company, its shareholders nor its directors and officers, has any duty or
obligation to disclose to the Employee 

  
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any material information regarding the business of the Company or affecting the value of the Shares before, at the time of, or following a termination of the employment of the Employee by the
Company, including, without limitation, any information concerning plans for the Company to make a public offering of its securities or to be acquired by or merged with or into another firm or entity. 

12.11 All certificates representing the Shares to be issued to the Employee pursuant to this Agreement shall have endorsed thereon a
legend substantially as follows: “The shares represented by this certificate are subject to restrictions set forth in an Incentive Stock Option Agreement dated
                     with this Company, a copy of which Agreement is available for inspection at the offices of the Company or will be made available
upon request.” 
  

	 	13.	NO OBLIGATION TO EMPLOY. 

The Company is not by the Plan or this Option obligated to continue the Employee as an employee of the Company or an Affiliate. The
Employee acknowledges: (i) that the Plan is discretionary in nature and may be suspended or terminated by the Company at any time: (ii) that the grant of the Option is a one-time benefit which does not create any contractual or other right
to receive future grants of options, or benefits in lieu of options; (iii) that all determinations with respect to any such future grants, including, but not limited to, the times when options shall be granted, the number of shares subject to
each option, the option price, and the time or times when each option shall be exercisable, will be at the sole discretion of the Company; (iv) that the Employee’s participation in the Plan is voluntary; (v) that the value of the
Option is an extraordinary item of compensation which is outside the scope of the Employee’s employment contract, if any; and (vi) that the Option is not part of normal or expected compensation for purposes of calculating any severance,
resignation, redundancy, end of service payments bonuses, long-service awards, pension or retirement benefits or similar payments. 
  

	 	14.	OPTION IS INTENDED TO BE AN ISO. 

 The parties each intend that the Option be an ISO so that the Employee (or the Employee’s Survivors) may qualify for the favorable tax treatment provided to holders of Options that meet the standards
of Section 422 of the Code. Any provision of this Agreement or the Plan which conflicts with the Code so that this Option would not be deemed an ISO is null and void and any ambiguities shall be resolved so that the Option qualifies as an ISO.
Nonetheless, if the Option is determined not to be an ISO, the Employee understands that neither the Company nor any Affiliate is responsible to compensate him or her or otherwise make up for the treatment of the Option as a Non-qualified Option and
not as an ISO. The Employee should consult with the Employee’s own tax advisors regarding the tax effects of the Option and the requirements necessary to obtain favorable tax treatment under Section 422 of the Code, including, but not
limited to, holding period requirements. 
  

	 	15.	NOTICE TO COMPANY OF DISQUALIFYING DISPOSITION. 

 The Employee agrees to notify the Company in writing immediately after the Employee makes a Disqualifying Disposition of any of the Shares acquired pursuant to the exercise of the

  
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Option. A Disqualifying Disposition is defined in Section 424(c) of the Code and includes any disposition (including any sale) of such Shares before the later of (a) two years after the
date the Employee was granted the Option or (b) one year after the date the Employee acquired Shares by exercising the Option, except as otherwise provided in Section 424(c) of the Code. If the Employee has died before the Shares are sold,
these holding period requirements do not apply and no Disqualifying Disposition can occur thereafter. 
  

	 	16.	NOTICES. 

 Any notices
required or permitted by the terms of this Agreement or the Plan shall be given by recognized courier service, facsimile, registered or certified mail, return receipt requested, addressed as follows: 

 

					
	If to the Company:	  	 Paratek Pharmaceuticals, Inc.
 75 Kneeland Street
 Boston, MA 02111
 617-275-0040 (Telephone)
 617-275-0039 (Fax)

Attn: Beverly A. Armstrong, General Counsel

		
	With a copy to:	  	 Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
 One Financial Center
 Boston, MA 02111
 617-542-2241 (Fax)
 Attn: Lewis J. Geffen, Esq.

			
	If to the Employee:	  	  
	  	
		  	  
	  	
		  	  
	  	

 or to such other address or addresses of which notice in the same manner has previously been given. Any such notice shall
be deemed to have been given upon the earlier of receipt, one business day following delivery to a recognized courier service or three business days following mailing by registered or certified mail. 

 

	 	17.	GOVERNING LAW. 

 This
Agreement shall be construed and enforced in accordance with the law of the State of Delaware, without giving effect to the conflict of law principles thereof. For the purpose of litigating any dispute that arises under this Agreement, the parties
hereby consent to exclusive jurisdiction in Massachusetts and agree that such litigation shall be conducted in the courts of Middlesex County, Massachusetts or the federal courts of the United States for the District of Massachusetts. 

  
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	 	18.	BENEFIT OF AGREEMENT. 

Subject to the provisions of the Plan and the other provisions hereof, this Agreement shall be for the benefit of and shall be binding
upon the heirs, executors, administrators, successors and assigns of the parties hereto. 
  

	 	19.	ENTIRE AGREEMENT. 

 This
Agreement, together with the Plan, embodies the entire agreement and understanding between the parties hereto with respect to the subject matter hereof and supersedes all prior oral or written agreements and understandings relating to the subject
matter hereof. No statement, representation, warranty, covenant or agreement not expressly set forth in this Agreement shall affect or be used to interpret, change or restrict the express terms and provisions of this Agreement, provided, however, in
any event, this Agreement shall be subject to and governed by the Plan. 
  

	 	20.	MODIFICATIONS AND AMENDMENTS. 

 The terms and provisions of this Agreement may be modified or amended as provided in the Plan. 
  

	 	21.	WAIVERS AND CONSENTS. 

Except as provided in the Plan, the terms and provisions of this Agreement may be waived, or consent for the departure therefrom granted,
only by written document executed by the party entitled to the benefits of such terms or provisions. No such waiver or consent shall be deemed to be or shall constitute a waiver or consent with respect to any other terms or provisions of this
Agreement, whether or not similar. Each such waiver or consent shall be effective only in the specific instance and for the purpose for which it was given, and shall not constitute a continuing waiver or consent. 

 

	 	22.	DATA PRIVACY. 

 By
entering into this Agreement, the Employee: (i) authorizes the Company and each Affiliate, and any agent of the Company or any Affiliate administering the Plan or providing Plan recordkeeping services, to disclose to the Company or any of its
Affiliates such information and data as the Company or any such Affiliate shall request in order to facilitate the grant of options and the administration of the Plan; (ii) waives any data privacy rights he or she may have with respect to such
information; and (iii) authorizes the Company and each Affiliate to store and transmit such information in electronic form. 

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 IN WITNESS WHEREOF, the Company has caused this Agreement to be executed by its duly
authorized officer, and the Employee has hereunto set his or her hand, all as of the day and year first above written. 
  

					
	PARATEK PHARMACEUTICALS, INC.
		
	By:	 	  

		 	Name:	 	Thomas J. Bigger
		 	Title:	 	President
	
	  

	Employee:

  
 13 

 Exhibit A 
 NOTICE OF EXERCISE OF INCENTIVE STOCK OPTION 
 [Form For Unregistered Shares]

  

	To:	PARATEK PHARMACEUTICALS, INC. 

 Ladies and Gentlemen: 
 I hereby exercise my Incentive Stock Option to purchase
                 shares (the “Shares”) of the common stock, $.001 par value per share, of Paratek Pharmaceuticals, Inc. (the “Company”), at the
exercise price of $             per share, pursuant to and subject to the terms of that certain Incentive Stock Option Agreement between the undersigned and the Company dated
                    . 
 I
am aware that the Shares have not been registered under the Securities Act of 1933, as amended (the “1933 Act”), or any state securities laws. I understand that the reliance by the Company on exemptions under the 1933 Act is predicated in
part upon the truth and accuracy of the statements by me in this Notice of Exercise. 
 I hereby represent and warrant that
(1) I have been furnished with all information which I deem necessary to evaluate the merits and risks of the purchase of the Shares; (2) I have had the opportunity to ask questions concerning the Shares and the Company and all questions
posed have been answered to my satisfaction; (3) I have been given the opportunity to obtain any additional information I deem necessary to verify the accuracy of any information obtained concerning the Shares and the Company; and (4) I
have such knowledge and experience in financial and business matters that I am able to evaluate the merits and risks of purchasing the Shares and to make an informed investment decision relating thereto. 

I hereby represent and warrant that I am purchasing the Shares for my own personal account for investment and not with a view to the sale
or distribution of all or any part of the Shares. 
 I understand that because the Shares have not been registered under the
1933 Act, I must continue to bear the economic risk of the investment for an indefinite time and the Shares cannot be sold unless the Shares are subsequently registered under applicable federal and state securities laws or an exemption from such
registration requirements is available. 
 I agree that I will in no event sell or distribute or otherwise dispose of all or any
part of the Shares unless (1) there is an effective registration statement under the 1933 Act and applicable state securities laws covering any such transaction involving the Shares or (2) the Company receives an opinion of my legal
counsel (concurred in by legal counsel for the Company) stating that such transaction is exempt from registration or the Company otherwise satisfies itself that such transaction is exempt from registration. 

  
 14 

 I consent to the placing of a legend on my certificate for the Shares stating that the
Shares have not been registered and setting forth the restriction on transfer contemplated hereby and to the placing of a stop transfer order on the books of the Company and with any transfer agents against the Shares until the Shares may be legally
resold or distributed without restriction. 
 I understand that at the present time Rule 144 of the Securities and Exchange
Commission (the “SEC”) may not be relied on for the resale or distribution of the Shares by me. I understand that the Company has no obligation to me to register the sale of the Shares with the SEC and has not represented to me that it
will register the sale of the Shares. 
 I understand the terms and restrictions on the right to dispose of the Shares set forth
in the 2005 Employee, Director and Consultant Stock Plan and the Incentive Stock Option Agreement, both of which I have carefully reviewed. I consent to the placing of a legend on my certificate for the Shares referring to such restriction and the
placing of stop transfer orders until the Shares may be transferred in accordance with the terms of such restrictions. 
 I have
considered the Federal, state and local income tax implications of the exercise of my Option and the purchase and subsequent sale of the Shares. 
 I am paying the option exercise price for the Shares as follows: 
  

 
 Please issue
the stock certificate for the Shares (check one): 
  ̈ to me; or 

 ̈ to me and
                    , as joint tenants with right of survivorship 
 and mail the certificate to me at the following address: 
  

					
	  
	  		  	
	  
	  		  	
	  
	  		  	

  
 15 

 My mailing address for shareholder communications, if different from the address listed
above is: 
  

					
	  
	  		  	
	  
	  		  	
	  
	  		  	

  

	
	Very truly yours,
	
	  

	Employee (signature)
	
	  

	Print Name
	
	  

	Date
	
	  

	Social Security Number

  
 16 

 Exhibit A 
 NOTICE OF EXERCISE OF INCENTIVE STOCK OPTION 
 [Form For Registered Shares]

  

	TO:	PARATEK PHARMACEUTICALS, INC. 

 IMPORTANT NOTICE: This form of Notice of Exercise may only be used at such time as the Company has filed a Registration Statement with the Securities and Exchange Commission under which the issuance of
the Shares for which this exercise is being made is registered and such Registration Statement remains effective. 
 Ladies and Gentlemen:

 I hereby exercise my Incentive Stock Option to purchase
                 shares (the “Shares”) of the common stock, $.001 par value, of Paratek Pharmaceuticals, Inc. (the “Company”), at the exercise price
of $                 per share, pursuant to and subject to the terms of that certain Incentive Stock Option Agreement between the undersigned and the Company dated
                    . 
 I
understand the nature of the investment I am making and the financial risks thereof. I am aware that it is my responsibility to have consulted with competent tax and legal advisors about the relevant national, state and local income tax and
securities laws affecting the exercise of the Option and the purchase and subsequent sale of the Shares. 
 I am paying the
option exercise price for the Shares as follows: 
  

 
 Please issue
the stock certificate for the Shares (check one): 
  ̈ to me; or 

 ̈ to me and
                    , as joint tenants with right of survivorship, 
 and mail the certificate to me at the following address: 
  

					
	  
	  		  	
	  
	  		  	
	  
	  		  	

 My mailing address for shareholder communications, if different from the address listed
above, is: 
  

					
	  
	  		  	
	  
	  		  	
	  
	  		  	

  

	
	Very truly yours,
	
	  

	Employee (signature)
	
	  

	Print Name
	
	  

	Date
	
	  

	Social Security Number

  
 2Employment Agreement, Thomas Bigger

 Exhibit 10.11 
 PARATEK PHARMACEUTICALS, INC. 
 75 Kneeland Street 

Boston, Massachusetts 02111 
 September 16, 1999 
 Mr. Thomas J. Bigger 

Dear Mr. Bigger: 
 This
letter is to confirm our understanding with respect to your employment by Paratek Pharmaceuticals, Inc. (the “Company”). In consideration of the mutual promises and covenants contained in this letter agreement (this “Agreement”),
and for other good and valuable consideration, the receipt and sufficiency of which are hereby mutually acknowledged, we have agreed as follows: 
 1. Employment. The Company will employ you, and you agree to be employed by the Company, to serve as its President and Chief Executive Officer, reporting to the Company’s Board of Directors,
and to perform such services and discharge such duties and responsibilities as may be prescribed by the Board of Directors (the “Board”) of the Company from time to time. In addition, it is contemplated that during the Term (as defined
below), the Board will appoint you or nominate you for election to the Board. You shall devote your full time and best efforts in the performance of the foregoing services. 
 2. Term of Employment. 
 (a) Term; Termination. Your employment
hereunder shall commence as of the date of this Agreement and shall continue until the third anniversary thereof (the “Initial Term”). The term of your employment shall renew automatically for any number of renewal terms of one year’s
duration each, unless either party to this Agreement provides written notice of its intention not to renew the Agreement at least ninety (90) days prior to the then effective expiration date. Notwithstanding the foregoing, your employment
hereunder shall be terminated upon the first to occur of the following: 
  

	 	(i)	immediately upon your death; or 

  

	 	(ii)	by the Company: 

 (A) upon
notice following your failure, due to illness, accident or any other physical or mental incapacity, to perform the services provided for hereunder for an aggregate of ninety (90) business days within any one year period during the term hereof;

 (B) upon notice for Cause (as defined below) and as set forth below; or 

 (C) subject to Section 3 hereof, without Cause, upon sixty (60) days’ prior
written notice to you of its intent to terminate your employment; or 
  

	 	(iii)	by you: 

 (A) without Good
Reason (as defined below) upon sixty (60) days’ prior written notice to the Company of your intent to terminate your employment; or 
 (B) subject to Section 3 hereof, with Good Reason, upon sixty (60) days’ prior written notice to the Company of your intent to terminate your employment. 

The right of the Company to terminate your employment hereunder without Cause, to which you hereby agree, shall be exercisable by written
notice sent to you by the Company. 
 (b) Definition of “Cause”. The Company may, immediately and unilaterally,
terminate your employment hereunder for Cause at any time upon ten (10) days’ advance written notice to you. Termination of your employment by the Company shall constitute a termination for Cause if such termination is for one or more of
the following reasons: (i) your willful misconduct or gross negligence; (ii) you are convicted of a felony, either in connection with the performance of your obligations to the Company or which conviction materially adversely affects your
ability to perform such obligations or materially adversely affects the business activities, reputation, goodwill or image of the Company; and, (iii) willful disloyalty, deliberate dishonesty or material uncured breach of fiduciary duty to the
Company or its shareholders. 
 In making any determination under this Section, the Board shall act fairly and in utmost good
faith and shall give you an opportunity to appear and be heard at a meeting of the Board or any committee thereof and present evidence on your behalf. For purposes of this Section, no act, or failure to act, on your part shall be considered
“willful” unless done, or admitted to be done, by you in bad faith and without reasonable belief that such action or omission was in the best interest of the Company. 

In the event you are terminated for Cause, you shall be entitled to no severance or other termination benefits, or any other benefits,
except that the Company shall continue to make available to you such fringe benefits as are required by law, and shall pay to you the pro rata amount of your Base Salary (as defined below) earned up to the date of said termination, said payment to
be made on the same date as said salary payment would have been made had there been no termination. Notwithstanding any termination of your employment, you shall continue to be bound by the provisions of this Agreement (other than Section 1
hereof). 
 (c) Definition of “Good Reason”. You may terminate your employment hereunder with Good Reason at
any time upon sixty (60) days’ advance written notice to the Company. Termination of your employment by you shall constitute a termination for “Good Reason” if such termination is a result of the Company’s continuing failure
to perform in any material respects its obligations to you pursuant to Section 1 of this Agreement, which failure of performance continues for a period of more than thirty (30) days after notice thereof has been provided by you to the
Board of Directors, such notice to set forth in reasonable detail the nature of such failure. Notwithstanding any termination of your employment, you shall continue to be bound by the provisions of this Agreement (other than Section 1 hereof).

  
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 3. Compensation. 

(a) Salary. The Company shall pay you as your base compensation for your services and agreements hereunder during the Initial Term
a base salary at the rate of Two Hundred Sixty Thousand Dollars ($260,000) per year (the “Base Salary”), payable at such intervals as may be agreed upon by the Company and you, less any amounts required to be withheld under applicable law.
Such compensation will be reduced by any disability payments which you receive, after taking into account the tax benefits (if any) of such payments. Your Base Salary will be reviewed annually by the Company’s Board of Directors and will not be
reduced without your consent. 
 (b) Bonus. In addition to your Base Salary, you will be entitled to cash bonuses of up
to thirty percent (30%) of your Base Salary in any year as determined from time to time by the Board in its discretion, taking into account, among other factors, your performance and the Company’s performance. 

(c) Present Grant of Options. Contemporaneously with the execution of this Agreement, you and the Company shall execute a Stock
Option Agreement pursuant to which you will receive options to purchase Five Hundred Nine Thousand Eight Hundred Ninety Six (509,896) shares of the Company’s Common Stock at an exercise price of thirty-five cents ($.35) per share, vesting
in equal annual installments over four years, pursuant to the Company’s 1996 Employee, Director and Consultant Stock Option Plan (the “Stock Option Plan”). 
 (d) Future Stock Options. During the course of your employment you will be eligible to receive stock options pursuant to the Company’s Stock Option Plan (or any successor plan) in such amounts
and pursuant to vesting schedules as may be determined from time to time by the Board in its discretion, taking into account, among other factors, your performance and the Company’s performance. 

(e) Severance; Termination without Cause or for Good Reason. In the event your employment shall be terminated during the Term of
this Agreement (i) by the Company without Cause, (ii) by you with Good Reason or (iii) in accordance with the Company’s notice to you of its election not to renew the Term pursuant to Section (a) hereof: 

(i) the Company shall continue to pay you your Base Salary and provide you with the benefits set forth in Section 4
hereof for a period equal to the lesser of (A) six (6) months subsequent to the date of such termination or (B) thirty (30) days following the date of your commencement of full-time employment with another employer; provided,
however, that if your annual salary with your new employer is less than your Base Salary under this Agreement, the Company shall pay you the difference between your Base Salary and the annual salary from your new employer for the balance of such six
(6) month period following the date of your termination by the Company (all such payments to be made at the times and at the rate specified in Section 3(a) hereof); 

  
 - 3 -

 (ii) in the event that the Company pays cash bonuses to executive officers
of the Company with respect to the year in which your employment was terminated by the Company without Cause or by you with Good Reason, then the Company shall pay you, at the time such other bonuses are generally paid, a cash bonus in an amount
equal to the amount that the Board in its discretion would have awarded you had your employment continued through such year, the payment of such amount to be pro rated based upon the portion of such year that your employment with the Company was
continuing; and 
 (iii) the vesting of your options to purchase shares of the Company’s Common Stock
granted to you pursuant to Section 3(c) or 3(d) shall be accelerated to the next occurring annual installment of the applicable vesting schedule. 
 Notwithstanding any termination of your employment, you shall continue to be bound by the provisions of this Agreement (other than Section 1 hereof). 

(f) Effect of Change of Control. Provided that the options to purchase shares of the Company’s Common Stock granted to you
pursuant to Section 3(c) or 3(d) hereof shall not otherwise have expired or been terminated pursuant to the terms of the Stock Option Plan, this Agreement or the agreement evidencing such options, such options will become fully vested and you
will have the right to exercise any and all of such options in the event that: 
 (i) (A) a Change of Control (as
defined below) occurs and (B) you continue your employment with the Company, or its successor, for a period of not less than one (1) year following the date of such Change of Control; or 

(ii) at any time during the one (1) year period following any such Change of Control, (A) the Company, or its
successor, terminates your employment, whether with or without Cause or (B) you terminate your employment with the company for Good Reason. 
 As used herein a “Change of Control” shall be deemed to have occurred if (i) any “person” (as such term is used in sections 13(d) and 14(d)(2) of the Securities Exchange Act of
1934, as amended), other than persons who are stockholders of the Company on the date of this Agreement, is or becomes the beneficial owner, directly or indirectly, of securities of the Company representing at least 51% of the outstanding Common
Stock of the Company, or (ii) if during any consecutive twelve (12) month period beginning on or after the date on which this Agreement is executed individuals who at the beginning of such period were directors of the Company (together
with any new directors whose election by the Board or whose nomination for election by the Company’s shareholders was approved by a vote of a majority of the directors then still in office who were either directors at the beginning of such
period or whose election or nomination was previously so approved) cease, for any reason, to constitute at least a majority of the Board, or (iii) if a merger of, or consolidation involving, the Company in which the Company’s stock is
converted into securities of another corporation or into cash shall be consummated, or a plan of complete liquidation of the Company (whether or not in connection with a sale of all or substantially all of the Company’s assets) shall be adopted
and consummated, or substantially all of the Company’s operating assets are sold (whether or not a plan of liquidation shall be adopted or a liquidation occurs), excluding in each case (A) a

  
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transaction solely for the purpose of reincorporating the Company in a different jurisdiction or recapitalizing or reclassifying the Company’s stock or (B) any merger or consolidation
in which the shareholders of the Company immediately prior to such merger or consolidation continue to own at least a majority of the outstanding voting securities of the Company or the surviving entity after such merger or consolidation.

 (g) Accrued and Unpaid Compensation. In the event of any termination of your employment for any reason, you (or your
estate) shall be paid such portion of your Base Salary, accrued vacation and unpaid incentive compensation (other than cash bonuses, which may be pursuant to Section 3(e)(ii) above), if any, as has accrued by virtue of your employment during
the period prior to termination and has not yet been paid, together with any amounts for expense reimbursement, other benefits and similar items which have been properly incurred in accordance with the provisions hereof prior to termination and have
not yet been paid. Such amounts shall be paid within ten (10) business days of the termination date. 
 4. Benefits and
Reimbursement of Expenses. 
 (a) Vacation and Holidays. You shall be entitled to four weeks of paid vacation plus
paid holidays in each year at a time or times (either consecutively or not consecutively) mutually agreeable to the Company and you, in accordance with the Company’s vacation and holiday policy in effect from time to time. 

(b) Employee Benefit Plans. You shall also be entitled to participate in the same manner as other executive employees of the
Company in any employee benefit plans which the Company provides or may establish for the benefit of its executive employees generally (including, without limitation, group life, medical, dental and other insurance, retirement, pension,
profit-sharing and similar plans). 
 (c) Reimbursement of Expenses. You shall be entitled to reimbursement for all
ordinary and reasonable out-of-pocket business expenses which are reasonably incurred by you in furtherance of the Company’s business in accordance with reasonable policies adopted from time to time by the Company. 

(d) Reimbursement of Relocation Expenses. In connection with your relocation from your current residence to a residence nearby the
Company’s headquarters in the Boston area, you shall be entitled to reimbursement of the following expenses: (i) the reasonable costs and expenses of hotel and airfare for you and your family for up to three (3) trips to Massachusetts
to find housing in the Boston area; and (ii) the reasonable costs and expenses incurred by you in connection with accepting this employment up to a maximum of Seventy Thousand Dollars ($70,000.00) including, without limitation, (A) the
cost of temporary housing, (B) a broker’s fee (not to exceed 6%) and out-of-pocket legal expenses, and state and local taxes (if any), incurred by you in connection with the sale of your current residence, (C) ordinary packing and
moving expenses reasonably incurred by you and (D) the purchase price for your new residence, plus out-of-pocket costs incurred in connection with such purchase, including legal costs and the expenses of a home inspection. 

  
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 (e) Additional Relocation Expenses; Advance. In addition to the relocation expenses
set forth in Section 4(d) above, in order to assist you with the relocation of you and your family to the Boston area, the Company shall advance to you an aggregate amount up to One Hundred and Fifty Thousand Dollars ($150,000.00) (the
“Advance”) pursuant to a Promissory Note. 
 5. Prohibited Solicitation. 

(a) During the period in which you are employed by the Company and for a period of two (2) years following the expiration or
termination of your employment, whether such termination is voluntary or involuntary, you agree that you shall not, without the prior written consent of the Company either individually or on behalf of or through any third party, directly or
indirectly, solicit, entice or persuade or attempt to solicit, entice or persuade any persons then serving as employees of or consultants to the Company or any present or future parent, subsidiary or affiliate of the Company to leave the services of
the Company or any such parent, subsidiary or affiliate for any reason. 
 (b) Survival of Agreement. Your agreement set
forth in this Section 5 shall survive the expiration or termination of this Agreement and the termination of your employment with the Company for any reason. 
 6. Protected Information. Upon execution of this Agreement, you shall execute and deliver a Noncompetition and Confidentiality Agreement in the form attached hereto as Annex A. 

7. Disclosure to Future Employers. You agree that you will provide, and, in the event that the Company reasonably believes that
you may have breached the provisions of this Agreement or the Noncompetition Agreement the Company may similarly provide, a copy of the covenants contained in Section 5 of this Agreement and the covenants contained in the Noncompetition and
Confidentiality Agreement to any business or enterprise which you may directly, or indirectly, own, manage, operate, finance, join, control or in which you participate in the ownership, management, operation, financing, or control, or with which you
may be connected as an officer, director, employee, partner, principal, agent, representative, consultant or otherwise. 
 8.
Records. Upon termination of your relationship with the Company, you shall deliver to the Company any property of the Company which may be in your possession including products, materials, memoranda, notes, records, reports, or other
documents or photocopies of the same. 
 9. No Conflicting Agreements. You hereby represent and warrant that you have no
commitments or obligations inconsistent with this Agreement and you hereby agree to indemnify and hold the Company harmless against loss, damage, liability or expense arising from any claim based upon circumstances alleged to be inconsistent with
such representation and warranty. 
 10. General. 

(a) Notices. All notices, requests, consents and other communications hereunder shall be in writing, shall be addressed to the
receiving party’s address set forth below or to such 

  
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other address as a party may designate by notice hereunder, and shall be either (i) delivered by hand, (ii) made by telecopy or facsimile transmission, (iii) sent by overnight
courier, or (iv) sent by registered mail, return receipt requested, postage prepaid. 
  

			
	If to the Company:	  	 Paratek Pharmaceuticals, Inc.

75 Kneeland Street
 Boston, MA 02111

Attention: Stuart B. Levy, M.D.
 Fax:
(617) 636-6912

		
	With a copy to:	  	 Lewis J. Geffen, Esquire

Mintz, Levin, Cohn, Ferris

  Glovsky and Popeo, P.C.
 One Financial Center
 Boston, MA 02111
 Fax: (617) 542-2241

		
	If to you:	  	 Thomas J. Bigger

 All notices, requests, consents and other communications hereunder shall be deemed to have been given either (i) if
by hand, at the time of the delivery thereof to the receiving party at the address of such party set forth above, (ii) if made by telecopy or facsimile transmission, at the time that receipt thereof has been acknowledged by electronic
confirmation or otherwise, (iii) if sent by overnight courier, on the next business day following the day such notice is delivered to the courier service, or (iv) if sent by registered mail, on the fifth business day following the day such
mailing is made. 
 (b) Entire Agreement. This Agreement embodies the entire agreement and understanding between the
parties hereto with respect to the subject matter hereof and supersedes all prior oral or written agreements and understandings relating to the subject matter hereof. No statement, representation, warranty, covenant or agreement of any kind not
expressly set forth in this Agreement shall change or restrict, the express terms and provisions of this Agreement. 
 (c)
Modifications and Amendments. The terms and provisions of this Agreement may be modified or amended only by written agreement executed by the parties hereto. 
 (d) Waivers and Consents. The terms and provisions of this Agreement may be waived, or consent for the departure therefrom granted, only by written document executed by the party entitled to the
benefits of such terms or provisions. No such waiver or consent shall be deemed to be or shall constitute a waiver or consent with respect to any other terms or provisions of this Agreement, whether or not similar. Each such waiver or consent shall
be effective only in the specific instance and for the purpose for which it was given, and shall not constitute a continuing waiver or consent. 
 (e) Assignment. The Company may assign its rights and obligations hereunder to any person or entity who succeeds to all or substantially all of the Company’s business;

  
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provided, however, that the Company shall provide you with notice of such assignment. Your rights and obligations under this Agreement may not be assigned by you without the prior
written consent of the Company. 
 (f) Benefit. All statements, representations, warranties, covenants and agreements in
this Agreement shall be binding on the parties hereto and shall inure to the benefit of the respective successors and permitted assigns of each party hereto. Nothing in this Agreement shall be construed to create any rights or obligations except
among the parties hereto, and no person or entity shall be regarded as a third-party beneficiary of this Agreement. 
 (g)
Governing Law. This Agreement and the rights and obligations of the parties hereunder shall be construed in accordance with and governed by the law of The Commonwealth of Massachusetts, without giving effect to the conflict of law principles
thereof. 
 (h) Arbitration. Except with respect to the provisions of Section 5 hereof, any controversy, dispute or
claim arising out of or in connection with this Agreement, or the breach, termination or validity hereof, shall be settled by final and binding arbitration to be conducted by an arbitration tribunal in Boston, Massachusetts, pursuant to the rules of
the American Arbitration Association. The arbitration tribunal shall consist of three arbitrators. The party initiating arbitration shall nominate one arbitrator in the request for arbitration and the other party shall nominate a second in the
answer thereto within thirty (30) days of receipt of the request. The two arbitrators so named will then jointly appoint the third arbitrator. If the answering party fails to nominate its arbitrator within the thirty (30) day period, or if
the arbitrators named by the parties fail to agree on the third arbitrator within sixty (60) days, the office of the American Arbitration Association in Boston, Massachusetts shall make the necessary appointments of such arbitrator(s). The
decision or award of the arbitration tribunal (by a majority determination, or if there is no majority, then by the determination of the third arbitrator, if any) shall be final, and judgment upon such decision or award may be entered in any
competent court or application may be made to any competent court for judicial acceptance of such decision or award and an order of enforcement. In the event of any procedural matter not covered by the aforesaid rules, the procedural law of the
Commonwealth of Massachusetts shall govern. 
 (i) Jurisdiction and Service of Process. Any legal action or proceeding
with respect to this Agreement shall be brought in the courts of The Commonwealth of Massachusetts or in the United States District Court for the District of Massachusetts. By execution and delivery of this Agreement, each of the parties hereto
accepts for itself and in respect of its property, generally and unconditionally, the jurisdiction of the aforesaid courts. Each of the parties hereto irrevocably consents to the service of process of any of the aforementioned courts in any such
action or proceeding by the mailing of copies thereof by certified mail, postage prepaid, to the party at its address set forth in Section 11(a) hereof. 
 (j) Severability. The parties intend this Agreement to be enforced as written. However, (i) if any portion or provision of this Agreement shall to any extent be declared illegal or
unenforceable by a duly authorized court having jurisdiction, then the remainder of this Agreement, or the application of such portion or provision in circumstances other than those as to which it is so declared illegal or unenforceable, shall not
be affected thereby, and each portion 

  
 - 8 -

 
and provision of this Agreement shall be valid and enforceable to the fullest extent permitted by law; and (ii) if any provision, or part thereof, is held to be unenforceable because of the
duration of such provision or the geographic area covered thereby, the Company and you agree that the court making such determination shall have the power to reduce the duration and/or geographic area of such provision, and/or to delete specific
words and phrases (“blue-penciling”), and in its reduced or blue-penciled form such provision shall then be enforceable and shall be enforced. 
 (k) Headings and Captions. The headings and captions of the various subdivisions of this Agreement are for convenience of reference only and shall in no way modify, or affect the meaning or
construction of any of the terms or provisions hereof. 
 (l) Injunctive Relief. You hereby expressly acknowledge that
any breach or threatened breach of any of the terms and/or conditions set forth in Section 5 of this Agreement will result in substantial, continuing and irreparable injury to the Company. Therefore, you hereby agree that, in addition to any
other remedy that may be available to the Company, the Company shall be entitled to injunctive relief by a court of appropriate jurisdiction in the event of any breach or threatened breach of the terms of Section 5 of this Agreement.

 (m) No Waiver of Rights, Powers and Remedies. No failure or delay by a party hereto in exercising any right, power or
remedy under this Agreement, and no course of dealing between the parties hereto, shall operate as a waiver of any such right, power or remedy of the party. No single or partial exercise of any right, power or remedy under this Agreement by a party
hereto, nor any abandonment or discontinuance of steps to enforce any such right, power or remedy, shall preclude such party from any other or further exercise thereof or the exercise of any other right, power or remedy hereunder. The election of
any remedy by a party hereto shall not constitute a waiver of the right of such party to pursue other available remedies. No notice to or demand on a party not expressly required under this Agreement shall entitle the party receiving such notice or
demand to any other or further notice or demand in similar or other circumstances or constitute a waiver of the rights of the party giving such notice or demand to any other or further action in any circumstances without such notice or demand.

 (n) Expenses. Each party hereto shall pay its own fees and expenses (including the fees of any attorneys, accountants,
appraisers or others engaged by such party) in connection with this Agreement and the transactions contemplated hereby. 
 (o)
Counterparts. This Agreement may be executed in one or more counterparts, and by different parties hereto on separate counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same
instrument. 

  
 - 9 -

 If the foregoing accurately sets forth our agreement, please so indicate by signing and
returning to us the enclosed copy of this letter. 
  

			
	Very truly yours,
	
	Paratek Pharmaceuticals, Inc.
		
	By:	 	       /s/ Stuart B. Levy

	Stuart B. Levy, M.D.
	President

 Accepted and Approved: 
  

	
	       /s/ Thomas J. Bigger

	Thomas J. Bigger

  
 - 10 -

 AMENDMENT NO. 1 TO EMPLOYMENT AGREEMENT 

This Amendment No. 1 to Employment Agreement (this “Amendment”), is made and entered into as of March 8, 2007,
by and between Paratek Pharmaceuticals, Inc., 75 Kneeland Street, Boston, Massachusetts 02111 (the “Company”), and Thomas J. Bigger, (the “Executive”). Capitalized terms used herein and not otherwise defined shall
have the meanings ascribed to those terms in the Employment Agreement (as such term is defined below). 
 RECITALS

 WHEREAS, the Company and the Executive previously entered into a letter agreement, dated September 16, 1999 (the
“Employment Agreement”); and 
 WHEREAS, each of the Company and the Executive desire to amend certain terms of
the Employment Agreement as set forth in this Amendment; 
 AGREEMENT 

NOW, THEREFORE, in consideration of the foregoing facts and the respective agreements of the Company and the Executive set forth below,
and for other good and valuable consideration, the receipt and sufficiency of which are hereby mutually acknowledged, the Company and the Executive, intending to be legally bound, agree as follows: 

1. The following text shall be inserted at the very end of the second sentence of Section 2(a) of the Employment Agreement:
“(the Initial Term, together with any such renewal terms, being the “Term”)”. 
 2. Section 2(c) of the
Employment Agreement shall be deleted in its entirety and replaced with the following: 
 “(c) Definition of “Good
Reason”. You may terminate your employment hereunder with Good Reason at any time upon sixty (60) days’ advance written notice to the Company. Termination of your employment by you shall constitute a termination for “Good
Reason” if such termination is a result of (i) the Company’s failure to perform in any material respects its obligations to you pursuant to Section 1, 3 or 4 of this Agreement, including, without limitation, any material
diminution of your duties, title, authority, responsibilities (or nature thereof) or reporting level, as they exist on the date hereof or as they may have been increased or improved during any term of employment hereunder other than due to
termination for Cause, which failure of performance continues for a period of more than thirty (30) days after notice thereof has been provided by you to the Board, such notice to set forth in reasonable detail the nature of such failure or
(ii) any requirement that you be principally based at any office or location more than 25 miles from the Company’s current offices in Boston, Massachusetts. Notwithstanding any termination of your employment, you shall continue to be bound
by the provisions of this Agreement (other than Section 1 hereof).” 

 3. The definition of “Base Salary” in Section 3(a) of the Employment
Agreement shall be amended to include any and all adjustments to the Executive’s Base Salary made by the Board from time to time subsequent to the Commencement Date. 
 4. The phrase “Subject to Section 3(f) below,” shall be placed at the very beginning of the first sentence of Section 3(e) of the Employment Agreement and the complete reference to
“Section 2(a)” shall replace the incomplete reference to “Section (a)” in such first sentence, such that the beginning of Section 3(e) will read as follows: 

“(e) Severance; Termination without Cause or for Good Reason. Subject to Section 3(f) below, in the event your employment
shall be terminated during the Term of this Agreement (i) by the Company without Cause, (ii) by you with Good Reason or (iii) in accordance with the Company’s notice to you of its election not to renew the Term pursuant to
Section 2(a) hereof:” 
 5. Section 3(e)(i) of the Employment Agreement shall be deleted in its entirety and
replaced with the following: 
 “(i) the Company shall continue to pay you your Base Salary and provide you with the
benefits set forth in Section 4 hereof, both as in effect on the date of such termination or non-renewal, whichever the case may be, for a period equal to the lesser of (A) twelve (12) months subsequent to the date of such termination
or (B) thirty (30) days following the date of your commencement of full-time employment with another employer; provided, however, if your annual salary with your new employer is less than your Base Salary under this
Agreement, the Company shall pay you the difference between your Base Salary and the annual salary from your new employer for the balance of such 12-month period following the date of your termination by the Company (all such payments to be made at
the times and at the rate specified in Section 3(a) hereof);” 
 6. Section 3(f) of the Employment Agreement,
except for the last paragraph of such Section, shall be deleted in its entirety and replaced with the following: 
 “(f)
Effect of Change of Control. If a Change of Control (as defined below) occurs and at any time during the 12-month period following any such Change of Control, (A) the Company, or its successor, terminates your employment, whether with or
without Cause, or (B) the Company, or its successor, elects not to renew this Agreement in accordance with its notice to you pursuant to Section 2(a) hereof, or (C) you terminate your employment with the Company, or its successor, for
Good Reason, then: 
 (i) the Company or its successor shall continue to pay you your Base Salary and provide you
with the benefits set forth in Section 4 hereof, both as in effect on the date of such termination or non-renewal, whichever the case may be, for a period equal to twelve (12) months subsequent to such date of termination; 

(ii) in the event that the Company or its successor pays cash bonuses to executive officers of the Company or such
successor with respect to the year in 

  
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which your employment was so terminated by the Company, then the Company or its successor shall pay you, at the time such other bonuses are generally paid, a cash bonus in an amount equal to the
amount that the Board or the board of directors (or comparable body) of the successor in its discretion would have awarded you had your employment continued through such twelve (12) months, the payment of such amount to be pro rated based upon
the portion of such year that your employment with the Company or such successor was continuing; and 
 (iii)
provided that any stock grants or options to purchase shares of the Company’s Common Stock granted to you shall not otherwise have expired or been terminated pursuant to the terms of the Stock Option Plan (or other Company stock incentive
plan), this Agreement or the agreement evidencing such stock grants or options, such stock grants or options will become fully vested, and you will have the right to exercise any and all of such options. In addition, notwithstanding anything
contained herein to the contrary, such stock grants and options will also become fully vested, and you will have the right to exercise any and all of such options in the event that (A) a Change of Control occurs and (B) you continue your
employment with the Company, or its successor, for a period of not less than twelve (12) months following the date of such Change of Control.” 
 Governing Law. This Amendment and the rights and obligations of the parties hereunder shall be construed in accordance with and governed by the laws of The Commonwealth of Massachusetts, without
giving effect to the conflict of law principles thereof. 
 Counterparts. This Amendment may be executed in one or more counterparts, and
by different parties hereto on separate counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. 
 [Remainder of page left blank intentionally — signature page to follow] 

  
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 The parties have duly executed this Amendment as of the date first written above.

  

			
	PARATEK PHARMACEUTICALS, INC.
		
	By:	 	       /s/ Beverly A. Armstrong

		 	Beverly A. Armstrong
		 	General Counsel and Chief
		 	Compliance Officer
	
	       /s/ Thomas J. Bigger

	Thomas J. Bigger

  
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