Document:

Restricted Stock Agreement between Keystone and Edward Orzetti

 Exhibit 10.20 
 RESTRICTED STOCK AGREEMENT 
 This RESTRICTED STOCK AGREEMENT (this
“Agreement”), dated as of the March 27, 2008 (the “Grant Date”), is entered into by and between Keystone Automotive Holdings, Inc., a Delaware corporation (the “Company”), and Edward Orzetti
(the “Executive”). 
 WHEREAS, the Executive is as of the date hereof employed by the Company; and 
 WHEREAS, it has been determined by the board of directors of the Company (the “Board”) that it would be in the best interests of the
Company, in order to provide incentives to the Executive, to grant the 60,000 shares of the Company’s Class L Common Stock, par value $.01 per share (“Class L Common”), and 540,000 shares of the Company’s Class A
Common Stock, par value $.01 per share (“Class A Common”), to the Executive (such shares collectively, the “Restricted Stock”). 
 NOW, THEREFORE, in consideration of the mutual covenants and promises hereinafter set forth and for other good and valuable consideration, the parties hereto hereby mutually covenant and agree as follows: 

1. Definitions. Capitalized terms used herein but not otherwise defined shall have the meaning set forth below: 
 “Code” means the Internal Revenue Code of 1986, as amended from time to time. 
 “Common Stock” means, collectively, the Class A Common and the Class L Common. 
 “Independent Third Party” shall mean any person who, immediately prior to the contemplated transaction, does not own in excess of 5% of
the Common Stock on a fully-diluted basis, who is not controlling, controlled by or under common control with any such 5% owner of the Common Stock and who is not the spouse or descendent (by birth or adoption) of any such 5% owner of the Common
Stock. 
 “Person” means an individual, a partnership, a corporation, a limited liability company, an association, a joint
stock company, a trust, a joint venture, an unincorporated organization and a governmental entity or any department, agency or political subdivision thereof. 
 “Sale of the Company” shall mean sale of the Company (or any successor thereto), including in one or more series of related transactions, to an Independent Third Party or group of Independent Third
Parties, pursuant to which such party or parties acquire, directly or indirectly, through one or more intermediaries, (i) equity securities of the Company constituting a majority of the outstanding capital stock of the Company (whether by
merger, consolidation, sale or transfer of the Company’s outstanding capital stock) or (ii) all or substantially all of the assets of the Company and its Subsidiaries on a consolidated basis. 

 “Stockholders Agreement” means the Stockholders Agreement, dated as of October 30,
2003, by and among the Company and its stockholders, as amended, restated or otherwise modified from time to time. 
 “Subsidiary” means with respect to any Person, any corporation, partnership, association or other business entity of which (i) if a corporation, a majority of the total voting power of shares of stock entitled (without
regard to the occurrence of any contingency) to vote in the election of directors is at the time owned or controlled, directly or indirectly, by that Person or one or more of the other Subsidiaries of that Person or a combination thereof, or
(ii) if a partnership, association or other business entity, a majority of the partnership or other similar ownership interest thereof is at the time owned or controlled, directly or indirectly, by any Person or one or more Subsidiaries of that
Person or a combination thereof. For purposes hereof, a Person or Persons shall be deemed to have a majority ownership interest in a partnership, association or other business entity if such Person or Persons shall be allocated a majority of
partnership, association or other business entity gains or losses or shall be or control the managing director or general partner of such partnership, association or other business entity. 
 2. Grant of Restricted Stock. The Company hereby grants to the Executive, as of the Grant Date, the shares of Restricted Stock specified
above. The Executive agrees and understands that nothing contained in this Agreement provides, or is intended to provide, the Executive with any protection against potential future dilution of the Executive’s stockholder interest in the Company
for any reason. 
 3. Vesting. 
 (a) Fifty (50%) of the Restricted Stock granted hereunder will vest on October 31, 2008 and the remaining fifty percent (50%) of the Restricted Stock granted hereunder will vest on June 30, 2010
(together with October 31, 2008, the “Vesting Dates”); provided, that the Executive is, and has been, continuously employed by the Company or any of its Subsidiaries from the Grant Date through each such Vesting Date.

 (b) Notwithstanding the foregoing, upon the consummation of a Sale of the Company, so long as Executive is, and has been, continuously
employed by the Company or any of its Subsidiaries from the date of this Agreement through the time immediately prior to consummation of the Sale of the Company, 100% of the shares of Restricted Stock granted to Executive shall become vested as of
the consummation of such Sale of the Company. 
 (c) Except as otherwise provided in this Section 3, if the Executive’s employment
with the Company and/or its Subsidiaries terminates for any reason prior to the vesting of all or any portion of the Restricted Stock awarded under this Agreement, such unvested portion of the Restricted Stock shall immediately be cancelled and the
Executive (and the Executive’s estate, designated beneficiary or other legal representative) shall forfeit any rights or interests in and with respect to any such shares of Restricted Stock. The Board, in its sole discretion, may determine,
prior to or within ninety (90) days after the date of any such termination, that all or a portion of any the Executive’s unvested shares of Restricted Stock shall not be so cancelled and forfeited. 
  

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 (d) Executive shall notify the Company promptly in the event that Executive elects to make an election
under Section 83(b) of the Code with respect to the Restricted Stock. 
 4. Transfer Restrictions; Delivery of Shares.

 (a) In addition to the stock certificate legends required by the Stockholders Agreement, all certificates representing unvested shares of
the Restricted Stock shall bear a legend as described below: 
 “THE SALE OR OTHER TRANSFER OF THE SHARES OF STOCK REPRESENTED BY THIS
CERTIFICATE, WHETHER VOLUNTARY, INVOLUNTARY, OR BY OPERATION OF LAW, IS SUBJECT TO CERTAIN RESTRICTIONS ON TRANSFER AS SET FORTH IN THE RESTRICTED STOCK AGREEMENT, DATED AS OF MARCH 27, 2008. A COPY OF SUCH RESTRICTED STOCK AGREEMENT MAY BE OBTAINED
FROM THE CHIEF FINANCIAL OFFICER OF KEYSTONE AUTOMOTIVE HOLDINGS, INC.” 
 (b) The Company shall hold all unvested shares of the
Restricted Stock as escrow agent so long as such shares remain unvested, together with stock powers or other instruments of assignment (including a power of attorney), each endorsed in blank with a guarantee of signature if deemed necessary or
appropriate by the Company, which would permit transfer to the Company of all or a portion of the shares of the Restricted Stock in the event any such shares of Restricted Stock is forfeited in whole or part. When shares of Restricted Stock awarded
by this Agreement become vested, the Executive shall be entitled to receive unrestricted shares of Restricted Stock and if the Executive’s stock certificates contain legends restricting the transfer of such Shares pursuant to this Agreement,
the Executive shall be entitled to receive new stock certificates free of such legends (provided that any legends required by the Stockholders Agreement may only be removed pursuant to the terms of the Stockholders Agreement). In connection with the
delivery of the unrestricted shares of Restricted Stock pursuant to this Agreement, the Executive agrees to execute any documents reasonably requested by the Company and acknowledges that all Restricted Stock will remain subject to the provisions of
the Stockholders Agreement. 
 5. Dividends and Other Distributions; Voting.  
 (a) Executive shall be entitled to receive all dividends and other distributions paid with respect to the Restricted Stock: provided, that any such
dividends or other distributions will be subject to same vesting requirements as the underlying Restricted Stock and shall be paid at the time the Restricted Stock becomes vested pursuant to Section 3. If any dividends or distributions are paid
in shares of capital stock, such shares shall be deposited with the Company and shall be subject to the same restrictions on transferability and forfeitability as the Restricted Stock with respect to which they were paid. 
  

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 (b) The Executive may exercise full voting rights with respect to the Restricted Stock granted hereunder.

 6. Non-transferability. Restricted Stock, and any rights and interests with respect thereto, issued under this Agreement
shall not, prior to vesting, be sold, exchanged, transferred, assigned or otherwise disposed of in any way by the Executive (or any beneficiary(ies) of the Executive), other than, subject to the terms of the Stockholders Agreement, by testamentary
disposition by the Executive or the laws of descent and distribution. Any such Restricted Stock, and any rights and interests with respect thereto, shall not, prior to vesting, be pledged, encumbered or otherwise hypothecated in any way by the
Executive (or any beneficiary(ies) of the Executive) and shall not, prior to vesting, be subject to execution, attachment or similar legal process. Any attempt to sell, exchange, transfer, assign, pledge, encumber or otherwise dispose of or
hypothecate in any way any of the Restricted Stock, or the levy of any execution, attachment or similar legal process upon the Restricted Stock, contrary to the terms and provisions of this Agreement and/or the Stockholders Agreement shall be null
and void and without legal force or effect. 
 7. Entire Agreement; Amendment. This Agreement, together with the Stockholders
Agreement, contains the entire agreement between the parties hereto with respect to the subject matter contained herein, and supersedes all prior agreements or prior understandings, whether written or oral, between the parties relating to such
subject matter. This Agreement may only be modified or amended by a writing signed by both the Company and the Executive. 
 8. Choice
of Law; Jurisdiction. ALL ISSUES AND QUESTIONS CONCERNING THE CONSTRUCTION, VALIDITY, ENFORCEMENT AND INTERPRETATION OF THIS AGREEMENT AND THE EXHIBITS AND SCHEDULES HERETO SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE LAWS OF
THE STATE OF DELAWARE, WITHOUT GIVING EFFECT TO ANY CHOICE OF LAW OR CONFLICT OF LAW RULES OR PROVISIONS, WHETHER OF THE STATE OF DELAWARE OR OTHERWISE, AND THE PARTIES HERETO HEREBY IRREVOCABLY SUBMIT TO THE JURISDICTION OF THE COURTS OF THE STATE
OF DELAWARE. 
 9. Notices. Any notice provided for in this Agreement shall be in writing and shall be either personally
delivered, sent by reputable overnight courier service or mailed by first class mail, return receipt requested, to the recipient at the address below indicated: 
 Notice to Executive: 
 Mr. Edward Orzetti 
 136 Glenwood Road 
 Ridgewood, NJ 07450

  

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 Notice to the Company: 
  

			
	Keystone Automotive Holdings, Inc.
	44 Tunkhannock Avenue
	Exeter, PA 18643
	Attention:	  	Board of Directors
	Fax:	  	(570) 655-8203

 With copies (which shall not constitute notice to the Company): 
  

			
	Bain Capital NY, LLC
	745 Fifth Avenue
	New York, NY 10151
	Attention:	  	Stephen Zide
	Fax:	  	(212) 421-2225
	
	Kirkland & Ellis, LLP
	153 East 53rd Street
	New York, NY 10022
	Attention:	  	Eunu Chun
	Fax:	  	(212) 446-4900

 10. Compliance with Laws. The issuance of the Restricted Stock or unrestricted
shares of Restricted Stock pursuant to this Agreement shall be subject to, and shall comply with, any applicable requirements of any federal and state securities laws, rules and regulations (including, without limitation, the provisions of the
Securities Act of 1933 (as amended) (the “1933 Act”), the Securities Exchange Act of 1934 (as amended), and the respective rules and regulations promulgated thereunder), and any other law or regulation applicable thereto. 

 11. Securities Law Restrictions. The Company shall not be obligated to issue any of the Restricted Stock or unrestricted
shares of Restricted Stock pursuant to this Agreement if such issuance would violate any such requirements. Executive represents and warrants that Executive will hold the Restricted Stock (whether or not vested) for his own account and not on behalf
of others. Executive understands and acknowledges that federal and state securities laws govern and restrict Executive’s right to offer, sell or otherwise dispose of any of the Restricted Stock unless Executive’s offer, sale or other
disposition thereof is registered under the 1933 Act, and state securities laws or, in the opinion of the Company’s counsel, such offer, sale or other disposition is exempt from registration thereunder. Executive agrees that he will not offer,
sell or otherwise dispose of any of the Restricted Stock (whether or not vested) in any manner which would (i) require the Company to file any registration statement (or similar filing under state law) with the Securities and Exchange
Commission or to amend or supplement any such filing or (ii) violate or cause the Company to violate the 1933 Act, the rules and regulations promulgated thereunder or any other state or federal law. Executive further understands that the
certificates for the unvested Restricted Stock will bear the legend set forth in Section 4 hereof or such other legends as the Company deems necessary or desirable in connection with the 1933 Act or other rules, regulations or laws. 

  

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 12. Binding Agreement; Assignment. This Agreement shall inure to the benefit of, be binding
upon, and be enforceable by the Company and its successors and assigns. The Executive shall not assign any part of this Agreement without the prior express written consent of the Company. 
 13. Counterparts. This Agreement may be executed in one or more counterparts, each of which shall be deemed to be an original, but all of
which shall constitute one and the same instrument. 
 14. Headings. The titles and headings of the various sections of this
Agreement have been inserted for convenience of reference only and shall not be deemed to be a part of this Agreement. 
 15. Further
Assurances. Each party hereto shall do and perform (or shall cause to be done and performed) all such further acts and shall execute and deliver all such other agreements, certificates, instruments and documents as any other party hereto
reasonably may request in order to carry out the intent and accomplish the purposes of this Agreement a and the consummation of the transactions contemplated thereunder. 
 16. Severability. The invalidity or unenforceability of any provisions of this Agreement in any jurisdiction shall not affect the validity, legality or enforceability of the remainder of this Agreement
in such jurisdiction or the validity, legality or enforceability of any provision of this Agreement in any other jurisdiction, it being intended that all rights and obligations of the parties hereunder shall be enforceable to the fullest extent
permitted by law. 
 *     *     *     *     * 
  

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 IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the date first written above.

  

			
	KEYSTONE AUTOMOTIVE HOLDINGS, INC.
		
	By:	 	 /s/ Donald T. Grimes

	Name:	 	DONALD T. GRIMES
	Title:	 	Executive Vice President and
		 	Chief Financial Officer
		
		 	 /s/ Edward Orzetti

		 	EDWARD ORZETTISecond Supplemental Indenture

 Exhibit 4.1 
 SECOND SUPPLEMENTAL INDENTURE, dated as of March 27, 2008, (“Second Supplemental Indenture”) between Nanogen, Inc., a corporation duly organized and existing under the laws of the State of
Delaware, as Issuer (the “Company”), having its principal office at 10398 Pacific Center Court, San Diego, California 92121, and The Bank of New York Trust Company, N.A., a national banking association, as Trustee (in such capacity,
the “Trustee”). Capitalized terms not otherwise defined herein shall have the meanings ascribed to them in the First Supplemental Indenture (as defined below). 
 RECITALS OF THE COMPANY 
 The Company and the Trustee executed and delivered that
certain Indenture, dated as of August 27, 2007 (the “Initial Indenture”) to provide for the issuance from time to time of securities as provided in the Initial Indenture. 
 The Company and Trustee executed and delivered that certain First Supplemental Indenture dated August 27, 2008 (the “First Supplemental
Indenture” together with the Initial Indenture as modified by the First Supplemental Indenture, the “Indenture”) in connection with the issuance of the Company’s 6.25% Senior Convertible Notes Due 2010 (each a
“Security” and collectively, the “Securities”). The Securities are the first series of securities authorized under the Initial Indenture. 
 In accordance with Section 9.02 of the Indenture, the Company, the Trustee and each Holder wish to enter into this Second Supplemental Indenture to
further modify the Indenture. 
 NOW, THEREFORE, THIS SECOND SUPPLEMENTAL INDENTURE WITNESSETH, that, for and in consideration of the
premises, the Company agrees with the Trustee as follows: 
 ARTICLE I 
 AMENDMENTS OF INDENTURE 
 Section 1.01 Amendment to
Section 1.01. Subject to Section 2.04 hereof, the definition of “Existing Indebtedness” “Permitted Indebtedness” and “Permitted Lien” in Section 1.01 of the First Supplemental Indenture are hereby
amended and restated in their entirety as follows: 
 “Existing Indebtedness” means the Indebtedness of the Company and its Subsidiaries
(i) pursuant to that certain General Conditions for Future Factoring Operations, dated December 12, 2006, executed by Nanogen Advanced in favor of GE Capital Finance S.p.A, not to exceed Four Million Euros (€4,000,000) at any one
time outstanding; (ii) pursuant to that certain Royalty Interest Assignment Agreement dated September 29, 2006 between the Company, Epoch Biosciences, Inc. (“Epoch”) and Drug Royalty Trust 9, that certain Supplemental Royalty
Interest Assignment Agreement entered into between the Company, Epoch and Drug Royalty LP1 in the 

 
form provided to the Collateral Agent and that certain Royalty Interest Assignment Agreement between Epoch, as assignor, and Drug Royalty LP2, as assignee,
in the form provided to the Collateral Agent, pursuant to which Epoch sold certain of its rights to receive royalty payments and related reports under the Second Amended and Restated Collaboration, License and Supply Agreement, dated as of
August 17, 2000, as amended by the First Side Agreement dated October 31, 2001, the Amendment No. 1 to the Second Amended and Restated Collaboration, License and Supply Agreement dated July 26, 2002 and Amendment No. 2 to
the Second Amended and Restated Collaboration, License and Supply Agreement dated as of December 31, 2005, with Applera Corporation, for an aggregate principal amount of such Indebtedness not to exceed $30 million at any one time outstanding;
(iii) Indebtedness pursuant to those certain non recourse sales of receivables by Nanogen Advanced sponsored by regional governments in Italy in an aggregate principal amount not to exceed One Million Euros (€1,000,000) at any one
time outstanding, and (iv) the Senior Secured Convertible Notes. 
 “Permitted Indebtedness” means (i) Existing Indebtedness;
(ii) other Indebtedness approved in writing by the Required Holders; (iii) Permitted Subordinated Indebtedness; (iv) the Securities pursuant to this Indenture and other Transaction Documents; (v) Indebtedness to finance the
purchase price of personal property (“Capital Lease Product Indebtedness”), provided that such Indebtedness does not exceed the lesser of the cost or fair market value of such property financed with such Indebtedness and does not
exceed $1,250,000 in the aggregate outstanding at any time; (vi) Indebtedness of the Company to any Subsidiary of the Company and Indebtedness of any Subsidiary of the Company to the Company or any other such Subsidiary; (vii) Indebtedness
in respect of taxes and other governmental charges incurred in the ordinary course of business and which are not due or are being contested in good faith by appropriate proceedings and for which adequate reserves have been provided for in accordance
with GAAP; (viii) Indebtedness resulting from the endorsement of negotiable instruments in the ordinary course of business; (ix) Indebtedness in respect of hedging arrangements entered in the ordinary course of business designed to manage
interest rates or interest rate risk or to protect against fluctuations in currency exchange rates, and not for purposes of speculations; (x) the Letters of Credit and other letters of credit, and reimbursement obligations in respect thereof,
in support of trade debt or statutory obligations and lease or similar obligations incurred in the ordinary course of business; (xi) Indebtedness incurred in the ordinary course of business of the Company and its Subsidiaries, in respect of
performance bonds, bid bonds, appeal bonds, completion bonds, surety bonds, completion guarantees, security deposits and similar obligations; (xii) Indebtedness in respect of tenant improvements, tenant inducements or other payments by
landlords in respect of improvements or alterations to property leased by the Company or its Subsidiaries outstanding as of March 13, 2008; (xiii) Indebtedness of a Person that becomes a Subsidiary, which Indebtedness existed at the time
such Person became a Subsidiary and was not incurred in contemplation of such Person becoming a Subsidiary; and (xiv) extensions, refinancing and renewals of Indebtedness described in clause (i), (iii) and (iv) of the definition of
Existing Indebtedness, provided that (a) any such refinancing is in an aggregate principal amount not greater than the aggregate principal amount of the Existing Indebtedness being renewed or refinanced, plus the amount of any premiums
required to be paid thereon and reasonable fees and expenses associated therewith, (b) such refinancing has a later or equal final maturity and longer or equal weighted average life than the Existing Indebtedness being renewed or refinanced,
and (c) the covenants, events of default, subordination and other provisions thereof (including any guarantees thereof) shall be, in the aggregate, no less favorable to the Holders than those contained in the Existing Indebtedness being renewed
or refinanced. 

 “Permitted Liens” means (i) any Lien for taxes not yet due or delinquent or being contested in good
faith by appropriate proceedings for which adequate reserves have been established in accordance with GAAP, (ii) any statutory Lien arising in the ordinary course of business by operation of law with respect to a liability that is not yet due
or delinquent, (iii) any Lien created by operation of law, such as materialmen’s liens, mechanics’ liens and other similar liens, arising in the ordinary course of business with respect to a liability that is not yet due or delinquent
or that are being contested in good faith by appropriate proceedings, (iv) Liens in respect of security deposits provided in the ordinary course of business and consistent with past practices; (v) Liens (A) upon or in any equipment
acquired or held by the Company or any of its Subsidiaries to secure the purchase price of such equipment or indebtedness incurred solely for the purpose of financing the acquisition or lease of such equipment, or (B) existing on such equipment
at the time of its acquisition, provided that the Lien is confined solely to the property so acquired and improvements thereon, and the proceeds of such equipment, (vi) Liens incurred in connection with the extension, renewal or refinancing of
the indebtedness secured by Liens of the type described in clauses (i) and (v) above, provided that any extension, renewal or replacement Lien shall be limited to the property encumbered by the existing Lien and the principal amount of the
Indebtedness being extended, renewed or refinanced does not increase, (vii) leases or subleases and licenses and sublicenses granted to others in the ordinary course of the Company’s business, not interfering in any material respect with
the business of the Company and its Subsidiaries taken as a whole, (viii) Liens in favor of customs and revenue authorities arising as a matter of law to secure payments of custom duties in connection with the importation of goods,
(ix) Liens arising from judgments, decrees or attachments in circumstances not constituting an Event of Default under Section 5.01(a)(viii), (x) Liens securing Existing Indebtedness and reimbursement obligations in respect of
Permitted Indebtedness described in subparagraphs (x) and (xi) of the Permitted Indebtedness definition, (xi) those certain Liens in debts, accounts, moneys and choses in action owing to or owned by Company or its Subsidiaries in
respect of “Products” and “Licensed Products”, where Products and Licensed Products refer to are any diagnostic kits and components and materials therefore defined by one of more claims of the “Patents” or derived from
“Inventions and Technology” referred to in that certain Memorandum of an Agreement made as of January 18, 1991 between Dr. George Jackowski and Spectral Diagnostic Inc. pursuant to which Dr Jackowski assigned his right title and
interest in the Patents, Inventions and Technology to Spectral Diagnostics Inc. in return for, among other things, a royalty payment and which Memorandum of Agreement was assigned by Spectral Diagnostics Inc. to the Company; and (xii) any Liens
granted in favor of, or held for the benefit of, the Company. 
 Section 1.02 Additional Definitions. Subject to Section 2.04
hereof, the following definitions are added to Section 1.01 of the First Supplemental Indenture in their respective alphabetical order as follows: 
 “Amendment and Exchange Agreements” means those certain Amendment and Exchange Agreements dated as of March 13, 2008 by and among the Company and each of the initial holders of those certain Senior Secured Convertible
Notes issued in exchange for certain portions of the Securities. 

 “Collateral Agent” means the Collateral Agent appointed pursuant to the Amendment and Exchange
Agreements (and any successor thereto). 
 “Senior Secured Convertible Notes” means those certain Senior Secured Convertible Notes issued
pursuant to the Amendment and Exchange Agreements. 
 Section 1.03 Amendment to Section 5.01. Subject to Section 2.04
hereof, Section 5.01(a)(ix) is amended and restated in its entirety to read as follows: 
 (ix) the Company breaches any covenant or other term or
condition or any material representation or warranty of any Transaction Document, except, in the case of a breach of a covenant or other term or condition which is curable, and provided that the Company delivers prompt notice of such breach to the
Holder, only if such breach continues for a period of at least ten (10) consecutive Business Days; 
 Section 1.04 Amendment to
Section 10.13. Subject to Section 2.04 hereof, Section 10.13 is amended and restated in its entirety to read as follows: 
 Section 10.13 Restricted Payments. The Company shall not, and the Company shall not permit any of its Subsidiaries to, directly or indirectly, redeem, defease, repurchase, repay or make any payments in respect of, by the payment
of cash or cash equivalents (in whole or in part, whether by way of open market purchases, tender offers, private transactions or otherwise), all or any portion of any Indebtedness (other than this Security, the Other Securities and the Senior
Secured Convertible Notes), whether by way of payment in respect of principal of (or premium, if any) or interest on such Indebtedness, if at the time such payment is due or is otherwise made or, after giving effect to such payment, an event
constituting, or that with the passage of time and without being cured would constitute, an Event of Default has occurred and is continuing; provided that notwithstanding the foregoing, no principal (or any portion thereof) of any Subordinated
Indebtedness may be paid (whether upon maturity, redemption, acceleration or otherwise) so long as this Note is outstanding. 
 ARTICLE II

 MISCELLANEOUS PROVISIONS; GOVERNING LAW; ACCEPTANCE BY TRUSTEE 
 Section 2.01 Instruments to be Read Together. This Second Supplemental Indenture is an indenture supplemental to and in implementation of the
Indenture, and said Indenture and this Second Supplemental Indenture shall henceforth be read together. 
 Section 2.02 Confirmation.
The Indenture as amended and supplemented by this Second Supplemental Indenture is in all respects confirmed and preserved. 
 Section 2.03
Counterparts. This Second Supplemental Indenture may be executed in any number of counterparts, each of which so executed shall be deemed to be an original, but all such counterparts shall together constitute but one and the same instrument.

 Section 2.04 Effectiveness. The provisions of this Second Supplemental Indenture will take effect
immediately upon its execution and delivery by the Trustee in accordance with the provisions of Section 9.02 of the Indenture. 
 Section 2.05 Governing Law. This Second Supplemental Indenture shall be construed in accordance with and governed by the laws of the State of New York. 
 Section 2.06 Acceptance by Trustee. The Trustee accepts the amendments of the Indenture effected by this Second Supplemental Indenture and agrees to execute the trusts created by the Indenture as hereby
amended, but only upon the terms and conditions set forth in the Indenture. The Trustee assumes no responsibility for the correctness of the recitals contained herein, which shall be taken as the statements of the Company. The Trustee makes no
representation and shall have no responsibility as to the validity of this Second Supplemental Indenture or the proper authorization or the due execution hereof by the Company. 
 [signature page follows] 

 IN WITNESS WHEREOF, the parties hereto have caused this Second Supplemental Indenture to be duly executed
as of the day and year first above written. 
  

			
	NANOGEN, INC.
		
	By:	 	 
		 	Name:
		 	Title:
	
	THE BANK OF NEW YORK TRUST COMPANY, N.A., as Trustee
		
	By:	 	 
		 	Name:
		 	Title:

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