Document:

May
      8,
      2002

    

    To:
      Mr.
      Yossi Ben-Yossef Kadima Hi-Tech

    

    Re:
      Investment in our company

    

    We
      are
      hereby to put in writing our agreement in respect of investment to be made
      by a
      group in investors handled by you, and / or other investors handled by
      you.

    

    	1.  	
            If
              an investment is made (hereinafter - “Investment”), then you and / or
              whoever on your behalf, shall be entitled to receive from
              us:

          

    	1.1.  	
            Success
              fee amounting 5% of the Investment + VAT (hereinafter - “Commission”).
              Commission will be fully paid to you in cash at the signing of the
              investment agreement with your investors (or any of them), and as will
              be
              ordered by the company. Commission will be paid in NIS, or where
              Investment is made if foreign currency, in NIS according to official
              US$ -
              NIS exchange rate know on the day of
              payment.

          

    	1.2.  	
            For
              12 months as of signing of said Investment agreement, you shall have
              an
              option to purchase shares of the company at an amount equal to 5% of
              the
              Investment (as defined supra)
              according to same company valuation as in the Investment (a s defined
              supra).
              It is hereby made clear that for the purpose of this article 1.2, all
              options allocated to company employees and / or others, will be considered
              as if exercised prior to exercising of this option by
              you.

          

    	2.  	
            Nothing
              in the document is to obligate you and / or Kadima and / or members
              of the
              forum, to execute an investment (and / or any investment) in the
              company.

          

    

    Sincerely
      yours,Rosetta
      Genomics Ltd.

    March
      3rd, 2003

     

     

    To

    

    Mr.
      Yossi
      Ben-Yossef 

    Kadima
      Hi-Tech ("Kadima")

     

    Dear
      Yossi,

    

    

    Re:
      Rosetta
      Genomics Ltd. (the "
      Company")
      - New Investment
      Round

    

    Pursuant
      to our conversation and for the sake of good order, following is a summary
      of
      the terms
      agreed in our conversation, with respect to the possible participation of new
      investors organized
      by Kadima, in Rosetta's contemplated new investment round:

    

    
      	
              1.

            	
              Rosetta
                is contemplating to close a new investment round of $2M from external
                investors
                at a pre-money valuation of $20M by not later than April 30, 2003
                (the
                "Investment
                Round"). The pre-money valuation may change in the event that the
                Investment
                Round is closed following the above-mentioned date.
                

            

      	 	 

    

    
      	
              2

            	
              Kadima
                will be entitled to organize a group of new external investors to
                participate in the
                Investment Round (such investors: the "Kadima Investors"), under
                the
                following terms:

            

      	 	 

    

    
      	
            	2.1 
              	
              All
                of the Kadima Investors will invest through Kadima, who will be their
                sole
                representative towards the Company. All of the shares to be allotted
                at
                the closing of the Investment Round, in consideration for the investment
                of the Kadima Investors, will be allotted to Kadima who will be the
                sole
                Company shareholder representing such Kadima Investors. For such
                purposes
                Kadima will enter into internal trust agreements with the Kadima
                Investors
                with respect to the holding of such shares, in the form already existing
                in relation to present investors introduced to the Company by Kadima
                or
                such other form approved in advance and in writing by the
                Company.

            

      	 	 	 

    

    
      	
            	2.2 
              	
              The
                terms of the Investment Round will be reflected in an investment
                Agreement, which will be drafted by Rosetta's counsels and will be
                sent to
                Kadima in the upcoming days.

            

      	 	 	 

    

    
      	
            	2.3 
              	
              Kadima
                will appoint one legal counsel who will represent all of the Kadima
                Investors in the negotiations with the Company's legal counsels,
                with
                respect to the terms of the Investment Agreement. The Company will
                not
                re-negotiate any material terms of the Investment Agreement with
                individual Kadima Investors.

            

      	 	 	 

    

    
      	
            	2.4 
              	
              Kadima
                will notify the Company in advance of the identity of the Kadima
                Investors,
                which will be subject to the Company's
                approval.

            

      	 	 	 

    

    
      	
              3.

            	
              Kadima
                shall be entitled to the following consideration for the investments
                made
                by Kadima
                Investors under the Investment Round:

            

      	 	 

    

    
      	
            	3.1 
              	
              A
                cash consideration equal to 5% of the cash investments, which will
                be made
                made
                by Kadima. Investors at the closing of the Investment
                Round.

            

    

    

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

    
      	
            	3.2 
              	
              In
                addition to the consideration specified in Section 3.1 above and
                taking
                into consideration the time and other constraints of the proposed
                investment, Kadima shall be entitled to an option to purchase an
                amount of
                ordinary shares of the Company equal to up to 2.5% of the amount
                of shares
                allotted by the Company to the Kadima Investors at the closing of
                the
                Investment Round, at the price per share of the Investment Round.
                The
                option will be valid for 18 months following the closing of the Investment
                Routed.

            

      	 	 	 

    

    
      	4.     
              	
              I
                would appreciate if you will confirm your agreement to the terms
                set forth
                in this
                Agreement
                by signing in the signature place
                below.

            

    

    

    
      	 	 	 
	 	Sincerely yours,
	 	
            
	 
 	 
 	 
 
	
            	By:  	/s/ 
Dr.
              Isaac Bentwich,
              CEO 
	 	
              

            
	 	
              Dr.
                Isaac Bentwich,
                CEO 

              Rosetta
                Genomics
                Ltd.

            

    

     

     

     

    
      
        

      

    We
      hereby
      confirm our agreement to the terms set forth above: 

     

    
      	 	 	 
	 	
            
	 
 	 
 	 
 
	
            	By:  	 
	 	
              

            
	 	
              Yossi
                Ben Yossef 

              Kadima
                Hi Tech

            

    

     

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

     

     

    
      	
            	3.1 
              	
              A
                cash consideration equal to 5% of the cash investments, which will
                be made
                by Kadima Investors at the closing of the Investment Round. VAT shall
                be
                added to such cash consideration against a proper tax invoice of
                Kadima.

            

      	 	 	 

    

    
      	
            	3.2 
              	
              In
                addition to the consideration specified in Section 3.1 above and
                taking
                into consideration the time and other constraints of the proposed
                investment, Kadima shall be entitled to an option to purchase an
                amount of
                ordinary shares of the Company equal to up to 2.5% of the amount
                of shares
                allotted by the Company to the Kadima Investors at the closing of
                the
                Investment Round, at the price per share of the Investment Round.
                The
                option will be valid for 18 months following the closing of the Investment
                Round.

            

      	 	 	 

    

    
      	
              4.

            	
              In
                the event that (i) Kadima's part of the $800k which the Company is
                currently contemplating to raise under the new 2003 internal bridge
                loan
                round (as set forth in the Company's letter to its existing shareholders
                and lender's dated March 9, 2003) is investment by the Kadima Lenders
                in
                full (as defined in the amendment letter to the Company’s 2003 bridge loan
                agreement, dated December 15, 2002 and (ii) all of the $2M, which
                the
                Company is contemplating to raise under the Investment Round will
                be
                invested by Kadima Investors, in accordance with sections 2.1 through
                2.3
                above then Kadima's existing option
                to
                purchase shares of the Company (with respect to investments which
                may be
                made by Kadima Investors), as set forth in Section 1.2 of the letter
                agreement between the Company and Kadima, [dated May-28, 2002) will
                be
                automatically extended for an additional period of twelve months
                (i.e. the
                aggregate period of the option will be 24
                months).

            

    

    

    
      	
              5.

            	
              I
                would appreciate if you will confirm your agreement to the terms
                set forth
                in this Agreement by signing in the signature place
                below.

            

    

     

     

    
      	 	 	 
	 	Sincerely
              yours,
	 
 	 
 	 
 
	 	By:  	/s/ 
Dr.
              Isaac Bentwich, CEO
	 	
              

            
	 	
              Dr.
                Isaac Bentwich, CEO 

              Rosetta
                Genomics Ltd

            

    

     

     

     

    
      
        

      

    We
      hereby
      confirm our agreement to the terms set forth above:

     

    
      	 	 	 
	 	
            
	 
 	 
 	 
 
	 	By:  	/s/ 
Yossi
              Ben Yossef
	 	
              

            
	 	
              Yossi
                Ben Yossef 

              Kadima
                Hi-Tech

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