Document:

Exhibit 4.1

 

THIS WARRANT AND THE SECURITIES REPRESENTED
BY THIS WARRANT HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”),
AND MAY NOT BE OFFERED, SOLD, ASSIGNED, PLEDGED, TRANSFERRED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF AN EFFECTIVE REGISTRATION
STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT, AND UPON DELIVERY
OF AN OPINION OF COUNSEL SATISFACTORY TO THE COMPANY THAT THE PROPOSED TRANSFER IS EXEMPT FROM THE SECURITIES ACT OR THAT THE PROSPECTUS
DELIVERY REQUIREMENTS HAVE BEEN MET.

 

COMMON STOCK PURCHASE WARRANT

 

To purchase shares of common stock, $0.0001
par value, of

 

Rock Creek Pharmaceuticals, Inc.

 

Dated: March 30, 2016

 

THIS COMMON STOCK PURCHASE WARRANT (the
“Warrant”) certifies that, for value received, [*] (the “Holder”) is entitled, upon the terms
and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after March 30, 2016 (the
“Initial Exercise Date”) and on or prior to the close of business on the seventh (7th) anniversary
of the Initial Exercise Date (the “Termination Date”) but not thereafter (the “Exercise Period”),
to subscribe for and purchase from Rock Creek Pharmaceuticals, Inc., a Delaware corporation (the “Company”),
up to [*] shares (the “Warrant Shares”) of common stock, par value $0.0001 per share, of the Company (the “Common
Stock”). The purchase price of one share of Common Stock (the “Exercise Price”) under this Warrant
shall be $1.12, subject to adjustment hereunder. The Exercise Price and the number of Warrant Shares for which the Warrant is exercisable
shall be subject to adjustment as provided herein. The term “Holder” shall refer to the Holder identified above
or any subsequent transferee of this Warrant. Capitalized terms used but not otherwise defined herein shall have the meanings set
forth in the Securities Purchase Agreement, dated March 30, 2016, between the Company and the Holder (the “Purchase Agreement”).

 

1.               
Authorization of Warrant Shares. The Company represents and warrants that all Warrant Shares which may be issued
upon the exercise of the purchase rights represented by this Warrant will, upon exercise of the purchase rights represented by
this Warrant, be duly authorized, validly issued, fully paid and nonassessable.

 

2.               
Exercise of Warrant.

 

(a)  Except as provided
in Section 3 herein, exercise of the purchase rights represented by this Warrant may be made at any time or times on or
after the Initial Exercise Date and on or prior to the close of business on the Termination Date by (i) surrendering this Warrant,
with the Notice of Exercise Form attached hereto completed and duly executed, to the offices of the Company (or such other office
or agency (including the transfer agent, if applicable) of the Company as it may designate by notice in writing to the registered
Holder at the address of such Holder appearing on the books of the Company), and (ii) (A) delivering to the Company payment of
the Exercise Price of the shares thereby purchased by wire transfer of immediately available funds or cashier’s check drawn
on a United States bank, or (B) if the provisions of Section 2(c) are applicable, by notifying the Company that this Warrant
is being exercised pursuant to a Cashless Exercise (as defined in Section 2(c) below). The Holder exercising his, her or
its purchase rights in accordance with the preceding sentence shall be entitled to receive a certificate for the number of Warrant
Shares so purchased, which certificate will bear a legend substantially similar to the legend set forth on this Warrant. Certificates
for shares purchased hereunder shall be issued and delivered to the Holder within five (5) Trading Days (as defined below) after
the date on which this Warrant shall have been exercised as aforesaid. This Warrant shall be deemed to have been exercised and
such certificate or certificates shall be deemed to have been issued, and the Holder shall be deemed to no longer hold this Warrant
with respect to such shares and to have become a holder of record of such shares for all purposes, in each case (i) if the exercise
is not a Cashless Exercise, as of the date the Warrant has been exercised by payment to the Company of the Exercise Price for such
shares and all taxes required to be paid by the Holder, if any, pursuant to Section 4 prior to the issuance of such shares,
have been paid, or (ii) if the exercise is a Cashless Exercise, as of the date the Warrant has been exercised with respect to such
shares, the Company has been notified that the Warrant is being exercised pursuant to a Cashless Exercise, and all taxes required
to be paid by the Holder, if any, pursuant to Section 4 prior to the issuance of such shares, have been paid.

 

     

     

    

 

(b)            
In the event that the Warrant is not exercised in full, the number of Warrant Shares shall be reduced by the number of such
Warrant Shares for which this Warrant is exercised and/or surrendered, and the Company, if requested by the Holder and at his,
her or its expense, shall within ten (10) Trading Days issue and deliver to the Holder a new Warrant of like tenor in the name
of the Holder or as the Holder (upon payment by the Holder of any applicable transfer taxes) may request, reflecting such adjusted
Warrant Shares.

 

(c)            
Notwithstanding anything herein to the contrary, if a registration statement covering the resale of the Warrant Shares that
are the subject of a completed and executed Notice of Exercise Form is not available for the resale of any or all Warrant Shares
(the “Unavailable Warrant Shares”), the Holder may, in his, her or its sole discretion, exercise this Warrant
in whole or in part and, in lieu of making the cash payment otherwise contemplated to be made to the Company upon such exercise
in payment of the aggregate Exercise Price, elect instead to receive upon such exercise the “Net Number” of
shares of Common Stock determined according to the following formula (a “Cashless Exercise”):

 

	Net Number = 	(A x B) - (A x C)
	 	D

 

For purposes
of the foregoing formula:

 

		A=	the total number of shares with respect to which this
Warrant is then being exercised.

 

		B=	the arithmetic average of the VWAPs (as defined below)
of the Common Stock for the five (5) consecutive Trading Days (as defined below) ending on the date immediately preceding the
date of the Notice of Exercise Form.

 

		C=	the Exercise Price then in effect for the applicable
Warrant Shares at the time of such exercise.

 

		D=	the Closing Sale Price (as defined below) of the Common
Stock on the date of the Notice of Exercise Form.

 

     

     

    

 

For purposes of Rule 144(d) promulgated
under the Securities Act, as in effect on the date hereof, it is intended that the Warrant Shares issued in a Cashless Exercise
shall be deemed to have been acquired by the Holder, and the holding period for the Warrant Shares shall be deemed to have commenced,
on the date this Warrant was originally issued pursuant to the Purchase Agreement.

 

(d)            
Notwithstanding anything herein to the contrary, this Warrant shall not be exercisable, and the Company shall not issue
to the Holder any shares of Common Stock underlying this Warrant, until such time when such shares (including shares issuable upon
exercise of the Warrants) proposed to be issued, when aggregated with all other shares then owned beneficially (as calculated pursuant
to Section 13(d) of the Securities Exchange Act of 1934 and Rule 13d-3 promulgated thereunder) by the Holder, would not result
in the beneficial ownership by the Holder of more than 9.99% of the then issued and outstanding shares of Common Stock (the “Ownership
Cap”), without the prior written consent of the Holder. The Ownership Cap shall be appropriately adjusted for any stock
dividend, stock split, reverse stock split or similar transaction.

 

(e)            
For purposes of this Warrant, the following terms shall have the following meanings:

 

(i)“Closing
Sale Price” means, for any security as of any date, the last closing trade price for such security on the Principal Market
(as defined below), as reported by Bloomberg, or, if the Principal Market begins to operate on an extended hours basis and does
not designate the closing trade price, then the last trade price of such security prior to 4:00:00 p.m., New York time, as reported
by Bloomberg, or, if the Principal Market is not the principal securities exchange or trading market for such security, the last
trade price of such security on the principal securities exchange or trading market where such security is listed or traded as
reported by Bloomberg, or if the foregoing do not apply, the last trade price of such security in the over-the-counter market on
the electronic bulletin board for such security as reported by Bloomberg, or, if no last trade price is reported for such security
by Bloomberg, the average of the bid prices, or the ask prices, respectively, of any market makers for such security as reported
in the OTC Link or “pink sheets” by OTC Markets Group Inc. (formerly Pink OTC Markets Inc.). If the Closing Sale Price
cannot be calculated for a security on a particular date on any of the foregoing bases, the Closing Sale Price of such security
on such date shall be the fair market value as mutually determined by the Company and the Holder. All such determinations shall
be appropriately adjusted for any stock dividend, stock split, stock combination, reclassification or other similar transaction
during the applicable calculation period.

 

(ii)“Trading
Day” shall mean a day on which there is trading on the Principal Market or such other market or exchange on which the
Common Stock is then principally traded.

 

(iii)“Principal
Market” means the OTCQB Venture Marketplace.

 

(iv)“VWAP”
means, for any security as of any date, the dollar volume-weighted average price for such security on the Principal Market during
the period beginning at 9:30:01 a.m., New York time, and ending at 4:00:00 p.m., New York time, as reported by Bloomberg through
its “Volume at Price” function. If VWAP cannot be calculated for such security on such date on any of the foregoing
bases, the VWAP of such security on such date shall be the fair market value as mutually determined by the Company and the Holder.
If the Company and the Holder are unable to agree upon the fair market value of such security, then such dispute shall be resolved
in accordance with the procedures hereunder. All such determinations shall be appropriately adjusted for any stock dividend, stock
split, stock combination or other similar transaction during such period.

 

     

     

    

 

3.               
No Fractional Shares or Scrip. No fractional shares or scrip representing fractional shares shall be issued upon
the exercise of this Warrant. As to any fraction of a share which the Holder would otherwise be entitled to purchase upon such
exercise, the Company shall pay a cash adjustment in respect of such final fraction in an amount equal to such fraction multiplied
by the Exercise Price.

 

4.               
Charges, Taxes and Expenses. Issuance of certificates for Warrant Shares shall be made without charge to the Holder
for any issue tax or other incidental expense in respect of the issuance of such certificate, all of which taxes and expenses shall
be paid by the Company, and such certificates shall be issued in the name of the Holder; provided, however, that the Holder
shall pay any applicable transfer taxes.

 

5.               
Closing of Books. The Company will not close its stockholder books or records in any manner which prevents the timely
exercise of this Warrant, pursuant to the terms hereof.

 

6.               
Division and Combination.

 

(a)            
This Warrant may be divided or combined with other Warrants upon presentation hereof (and thereof, as applicable) at the
aforesaid office of the Company, together with a written notice specifying the denominations in which new Warrants are to be issued,
signed by the Holder or his, her or its agent or attorney. The Company shall execute and deliver a new Warrant or Warrants in exchange
for the Warrant or Warrants to be divided or combined in accordance with such notice.

 

(b)            
The Company shall prepare, issue and deliver at its own expense (other than transfer taxes) the new Warrant or Warrants
under this Section 6.

 

7.               
No Rights as Stockholder until Exercise. This Warrant does not entitle the Holder to any voting rights or other rights
as a stockholder of the Company prior to the exercise hereof. Upon the surrender of this Warrant and, if the exercise is not a
Cashless Exercise, the payment of the aggregate Exercise Price, the Warrant Shares so purchased shall be and be deemed to be issued
to such Holder as the record owner of such shares as of the close of business on the later of the date of such surrender or payment,
and this Warrant shall no longer be issuable with respect to such Warrant Shares.

 

8.               
Loss, Theft, Destruction or Mutilation of Warrant. The Company covenants that, upon receipt by the Company of evidence
reasonably satisfactory to it of the loss, theft, destruction or mutilation of this Warrant or any stock certificate relating to
the Warrant Shares, and in the case of loss, theft or destruction, of indemnity or security reasonably satisfactory to it, and
upon surrender and cancellation of such Warrant or stock certificate, if mutilated, the Company will make and deliver a new Warrant
or stock certificate of like tenor and dated as of such cancellation, in lieu of such Warrant or stock certificate.

 

9.               
Saturdays, Sundays, Holidays, etc. If the last or appointed day for the taking of any action or the expiration of
any right required or granted herein shall be a Saturday, Sunday or legal holiday, then such action may be taken or such right
may be exercised on the next succeeding day not a Saturday, Sunday or legal holiday.

 

10.           
Adjustments and Termination of Rights. The purchase price per Warrant Share and the number of Warrant Shares purchasable
hereunder are subject to adjustment from time to time as follows:

 

     

     

    

 

(a)            
Reclassification, Recapitalization, etc. If the Company at any time shall, by reclassification of securities, recapitalization,
automatic conversion, or other similar event affecting the number or character of outstanding shares of Common Stock, or otherwise,
change any of the securities as to which purchase rights under this Warrant exist into the same or a different number of securities
of any other class or classes, this Warrant shall thereafter represent the right to acquire such number and kind of securities
as would have been issuable as the result of such change with respect to the securities that were subject to the purchase rights
under this Warrant immediately prior to such reclassification or other change.

 

(b)            
Split, Subdivision or Combination of Shares. If the Company at any time while this Warrant remains outstanding and
unexpired shall split, subdivide or combine the securities as to which purchase rights under this Warrant exist, the Exercise Price
shall be proportionately decreased in the case of a split or subdivision or proportionately increased in the case of a combination.

 

(c)            
Stock Dividends. If the Company at any time while this Warrant is outstanding and unexpired shall pay a dividend
with respect to Common Stock payable in shares of Common Stock, or make any other distribution with respect to Common Stock of
shares of Common Stock, then the Exercise Price shall be adjusted, from and after the date of determination of the shareholders
entitled to receive such dividend or distribution, to that price determined by multiplying the Exercise Price in effect immediately
prior to such date of determination by a fraction (i) the numerator of which shall be the total number of shares of Common
Stock outstanding immediately prior to such dividend or distribution, and (ii) the denominator of which shall be the total
number of shares of Common Stock outstanding immediately after such dividend or distribution.

 

(d)            
Adjustment of Number of Warrant Shares. Upon each adjustment in the Exercise Price pursuant to Sections 10(b)
or 10(c) hereof, the number of Warrant Shares purchasable hereunder shall be adjusted to the product obtained by multiplying
the number of Warrant Shares purchasable immediately prior to such adjustment in the Exercise Price by a fraction (i) the
numerator of which shall be the Exercise Price immediately prior to such adjustment, and (ii) the denominator of which shall
be the Exercise Price immediately after such adjustment.

 

(e)            
Other Action Affecting Shares. In case the Company shall take any action to which the provisions hereof are not strictly
applicable but are of the type contemplated by the provisions of this Section 10, then the Company’s board of directors
shall in good faith determine and implement an appropriate adjustment in the Exercise Price and the number of Warrant Shares (if
applicable) so as to protect the rights of the Holder.

 

11.             
Notice of Adjustments, Notices. If the Exercise Price or number or type of securities issuable hereunder shall be
adjusted pursuant to Section 10 hereof, the Company shall issue and provide to the Holder, as holder of this Warrant,
a certificate signed by an officer of the Company setting forth, in reasonable detail, the event requiring the adjustment, the
amount of the adjustment, the method by which such adjustment was calculated and the Exercise Price and number of Warrant Shares
purchasable hereunder after giving effect to such adjustment.

 

12.             
Authorized Shares. The Company covenants that, during the period the Warrant is outstanding, it will reserve from
its authorized and unissued Common Stock a sufficient number of shares to provide for the issuance of the Warrant Shares upon the
exercise of any purchase rights under this Warrant. The Company will take all such reasonable action as may be necessary to ensure
that such Warrant Shares may be issued as provided herein without violation of any applicable law or regulation.

 

Except as and to the
extent waived or consented to by the Holder, the Company shall not by any action, including, without limitation, amending its certificate
of incorporation or through any reorganization, transfer of assets, consolidation, merger, dissolution, issue or sale of securities
or any other voluntary action, avoid or seek to avoid the observance or performance of any of the terms of this Warrant, but will
at all times in good faith assist in the carrying out of all such terms and in the taking of all such actions as may be necessary
or appropriate to protect the rights of the Holder as set forth in this Warrant against impairment. Without limiting the generality
of the foregoing, the Company will (a) not increase the par value of any Warrant Shares above the amount payable therefor upon
such exercise immediately prior to such increase in par value and (b) take all such action as may be necessary or appropriate in
order that the Company may validly and legally issue fully paid and nonassessable Warrant Shares upon the exercise of this Warrant.

 

13.             
Miscellaneous.

 

(a)            
Jurisdiction. This Warrant shall constitute a contract under the laws of the State of New York, without regard to
its conflict of law, principles or rules.

 

(b)            
Restrictions. The Holder acknowledges that the Warrant Shares acquired upon the exercise of this Warrant will have
restrictions upon resale imposed by state and federal securities laws and/or as set forth in the Purchase Agreement.

 

(c)            
Nonwaiver and Expenses. No course of dealing or any delay or failure to exercise any right hereunder on the part
of the Holder shall operate as a waiver of such right or otherwise prejudice the Holder’s rights, powers or remedies, provided,
however, that all rights hereunder terminate on the Termination Date. If the Company willfully and knowingly fails to comply with
any provision of this Warrant, which results in any material damages to the Holder, the Company shall pay to the Holder such amounts
as shall be sufficient to cover any costs and expenses including, but not limited to, reasonable attorneys’ fees, including
those of appellate proceedings, incurred by the Holder in collecting any amounts due pursuant hereto or in otherwise enforcing
any of his, her or its rights, powers or remedies hereunder.

 

(d)            
Notices. All notices, requests, consents and other communications provided for herein shall be in writing and shall
be effective upon delivery in person or five business days after being mailed by certified or registered mail, return receipt requested,
postage pre-paid, addressed as follows:

 

(i)              If to the Holder to the address of the Holder as shown on the books of the Company; or

 

(ii)            
If to the Company:

 

Rock Creek Pharmaceuticals, Inc.

2040 Whitfield Avenue, Suite 300

Sarasota, Florida 34243

Telephone: (844) 727-0727

Attention: Chief Financial Officer

 

or at such other address as the
Holder or the Company, as applicable, may hereafter provide to the other in accordance with the provisions of this paragraph.

 

     

     

    

 

(e)            
Limitation of Liability. No provision hereof, in the absence of any affirmative action by the Holder to exercise
this Warrant or purchase Warrant Shares, and no enumeration herein of the rights or privileges of the Holder, shall give rise to
any liability of the Holder for the purchase price of any Common Stock or as a stockholder of the Company, whether such liability
is asserted by the Company or by creditors of the Company.

 

(f)             
Successors and Assigns; No Assignment. This Warrant and the rights and obligations evidenced hereby shall inure to
the benefit of and be binding upon the successors of the Company, provided that neither the Company (except in connection with
a sale of the Company or substantially all of the assets of the Company or a merger involving the Company) nor the Holder may assign
this Warrant without the prior written consent of the other party.

 

(g)            
Amendment. This Warrant may be modified or amended or the provisions hereof waived with the written consent of the
Company and the Holder.

 

(h)            
Severability. Wherever possible, each provision of this Warrant shall be interpreted in such manner as to be effective
and valid under applicable law, but if any provision of this Warrant shall be prohibited by or invalid under applicable law, such
provision shall be ineffective to the extent of such prohibition or invalidity, without invalidating the remainder of such provisions
or the remaining provisions of this Warrant.

 

(i)              
Headings. The headings used in this Warrant are for convenience of reference only and shall not, for any purpose,
be deemed a part of this Warrant.

 

[Signature page follows.]

 

     

     

    

 

IN WITNESS WHEREOF,
the Company has caused this Warrant to be executed by its officer thereunto duly authorized.

 

	 	ROCK CREEK PHARMACEUTICALS, INC.
	 	 	 
	 	By: 	 
	 	 	Name: Michael J. Mullan
	 	 	Title: Chairman and Chief Executive Officer

 

     

     

    

 

NOTICE OF EXERCISE

 

To:Rock Creek Pharmaceuticals, Inc.

 

(1)The undersigned
hereby elects to purchase ______________ Warrant Shares of Rock Creek Pharmaceuticals, Inc. pursuant to the terms of the attached
Warrant. Capitalized terms used but not otherwise defined herein shall have the meanings set forth in the attached Warrant.

 

(2) The undersigned
intends that payment of the Exercise Price shall be made as:

 

		£	a “Cash Exercise” with respect to ______________ Warrant Shares; and/or

		£	a “Cashless Exercise” pursuant to Section 2(c) of the Warrant with respect to
______________ Warrant Shares (only if permitted pursuant to Section 2(c)).

 

(3) In the event
that the undersigned has elected a Cash Exercise with respect to some or all of the Warrant Shares to be issued pursuant hereto,
the undersigned tenders herewith payment of the exercise price in full, together with all applicable transfer taxes, if any. Payment
shall take the form of lawful money of the United States.

 

(4)Please issue a
certificate or certificates representing said Warrant Shares in the name of the undersigned. The Warrant Shares shall be delivered
to the following:

_______________________________

_______________________________

_______________________________

 

(5)Accredited Investor/Qualified
Institutional Buyer. The undersigned is an “accredited investor” as defined in Regulation D under the Securities Act
of 1933, as amended.

 

	 	PURCHASER
	 	 	 
	 	By:	 
	 	 	Name:
	 	 	Title:
	 	Dated:Exhibit 10.1

 

 

 

SECURITIES
PURCHASE AGREEMENT

 

Between

 

ROCK CREEK
PHARMACEUTICALS, INC.,

 

as
Issuer,

 

And

 

[*]

 

as
Investor.

 

 

Dated: March 30, 2016

 

     

     

    

 

This SECURITIES PURCHASE
AGREEMENT (this “Agreement”) is entered into and effective as of March 30, 2016, between Rock Creek Pharmaceuticals,
Inc., a Delaware corporation (the “Company”), and [*] (“Investor”).

 

WHEREAS, the Company
and Investor desire that, upon the terms and conditions set forth in this Agreement: (i) Investor will purchase from the Company,
and the Company will issue and sell to Investor, the number of shares (the “Shares”) of the Company’s
common stock (“Common Stock”) set forth on the Investor’s signature page hereto for a purchase price per
share equal to $0.35; and (ii) Investor will acquire from the Company, and the Company will grant and issue to Investor, a warrant,
substantially in the form attached hereto as Exhibit A (the “Warrant”), to purchase the number of shares
of the Company’s Common Stock equal to two (2) times the number of Shares purchased pursuant to foregoing clause (i) (the
“Warrant Shares”) at an initial exercise price of $1.12 per share.

 

NOW, THEREFORE, in
consideration of the foregoing premises and the covenants contained herein and other good and valuable consideration, the receipt
and sufficiency of which are hereby acknowledged, the parties hereto agree as follows:

 

1.                 
Agreement to Sell and Purchase the Shares and the Warrant. At the Closing (as defined below), the Company will sell
to Investor, and Investor will purchase from the Company, upon the terms and subject to the conditions hereinafter set forth, the
Shares and the Warrant for the aggregate purchase price set forth on the Investor’s signature page hereto.

 

2.                 
Delivery of the Shares and the Warrant at Closing.

 

(a)         
The completion of the purchase, sale and issuance of the Shares and the Warrant (the “Closing”) shall
occur on the date of this Agreement or on such other date as the Company and Investor shall agree (the “Closing Date”),
at the offices of the Company’s counsel. At the Closing, the Company shall issue to Investor: (i) one or more stock certificates,
registered in Investor’s name and address as set forth on the Investor’s signature page hereto, representing the Shares,
and (ii) the Warrant issued in the name of Investor.

 

The Company’s
obligation to issue the Shares and the Warrant to Investor shall be subject to the following conditions, any one or more of which
may be waived by the Company: (i) receipt by the Company of a wire transfer of immediately available funds to an account designated
in writing by the Company, in the full amount of the total purchase price payable by Investor for the Shares and the Warrant that
Investor is hereby agreeing to purchase, as set forth on the Investor’s signature page hereto; and (ii) the accuracy,
in all material respects, of the representations and warranties made by Investor and the fulfillment, in all material respects,
of those undertakings of Investor to be fulfilled prior to the Closing.

 

Investor’s obligation
to purchase the Shares and the Warrant shall be subject to the following conditions, any one or more of which may be waived by
Investor (provided that no such waiver shall be deemed given unless in writing and executed by Investor): (i) receipt by Investor
of a counter-signed copy of this Agreement executed by the Company; (ii) receipt by Investor of a copy of the Warrant; (iii) receipt
by Investor of evidence of irrevocable instructions issued by the Company to the Company’s transfer agent instructing the
transfer agent to issue to Investor a stock certificate representing Investor’s Shares (subject to full satisfaction of the
conditions to Closing set forth in this Section 2); and (iv) the accuracy, in all material respects, of the representations
and warranties made by the Company and the fulfillment, in all material respects, of those undertakings of the Company to be fulfilled
prior to the Closing.

 

     

     

    

 

(b)        
The Company shall not issue to Investor any Shares or Warrant Shares under this Agreement until such time when such shares
proposed to be issued, when aggregated with all other shares then owned beneficially (as calculated pursuant to Section 13(d) of
the Securities Exchange Act of 1934 and Rule 13d-3 promulgated thereunder) by Investor would not result in the beneficial ownership
by Investor of more than 9.99% of the then issued and outstanding shares of Common Stock (the “Ownership Cap”),
without the prior written consent of Investor. The Ownership Cap shall be appropriately adjusted for any stock dividend, stock
split, reverse stock split or similar transaction.

 

3.                 
Representations, Warranties and Covenants of the Company. The Company hereby represents and warrants to, and covenants
with, Investor as follows as of the date of this Agreement and as of the Closing Date:

 

3.1.           
Organization. Each of the Company and its Subsidiaries (as defined in Rule 405 under the Securities Act of 1933,
as amended (the “Securities Act”)) is duly organized and validly existing in good standing under the laws of
the jurisdiction of its organization. Each of the Company and its Subsidiaries has full power and authority to own, operate and
occupy its properties and to conduct its business as presently conducted and is registered or qualified to do business and in good
standing in each jurisdiction in which it owns or leases property or transacts business and where the failure to be so qualified
would have a material adverse effect upon the financial condition or business, operations, assets or prospects of the Company and
its Subsidiaries, taken as a whole (a “Material Adverse Effect”).

 

3.2.           
Due Authorization. The Company has all requisite power and authority to execute, deliver and perform its obligations
under this Agreement and the Warrant, and has taken all necessary corporate action to enter into and perform this Agreement, to
issue the Shares in accordance with the terms of this Agreement, to enter into and perform the Warrant, and to issue the Warrant
Shares in accordance with the terms of the Warrant. This Agreement has been, and upon the Closing in accordance with the terms
of this Agreement, the Warrant will be, duly authorized, validly executed and delivered by the Company and constitute, or will
constitute, legal, valid and binding agreements of the Company enforceable against the Company in accordance with their terms,
except as enforceability may be limited by applicable bankruptcy, insolvency, reorganization, moratorium or similar laws affecting
creditors’ and contracting parties’ rights generally and except as enforceability may be subject to general principles
of equity (regardless of whether such enforceability is considered in a proceeding in equity or at law). Upon their issuance in
accordance with the terms of this Agreement, the Shares will be duly authorized, validly issued, fully paid and non-assessable,
the Warrant will be duly authorized and validly issued, and the Warrant Shares, upon exercise of the Warrant in accordance with
its terms, will be duly authorized.

 

3.3.           
Non-Contravention. Except as would not reasonably be expected to have a Material Adverse Effect, the execution and
delivery of this Agreement, the issuance and sale of the Shares and the Warrant under this Agreement, the fulfillment of the terms
of this Agreement and the consummation of the transactions contemplated hereby will not (i) conflict with or constitute a violation
of, or default (with or without the giving of notice or the passage of time or both) under, (A) any material bond, debenture, note
or other evidence of indebtedness, or under any material lease, indenture, mortgage, deed of trust, loan agreement, joint venture
or other agreement or instrument to which the Company or any Subsidiary is a party or by which it or any of its Subsidiaries or
their respective properties are bound, (B) the charter, by-laws or other organizational documents of the Company or any Subsidiary,
or (C) any law, administrative regulation, ordinance or order of any court or governmental agency, arbitration panel or authority
applicable to the Company or any Subsidiary or their respective properties, or (ii) result in the creation or imposition of any
lien, encumbrance, claim, security interest or restriction whatsoever upon any of the material properties or assets of the Company
or any Subsidiary or an acceleration of indebtedness pursuant to any obligation, agreement or condition contained in any material
bond, debenture, note or any other evidence of indebtedness or any material indenture, mortgage, deed of trust or any other agreement
or instrument to which the Company or any Subsidiary is a party or by which any of them is bound or to which any of the property
or assets of the Company or any Subsidiary is subject. No consent, approval, authorization or other order of, or registration,
qualification or filing with, any regulatory body, administrative agency, self-regulatory organization, stock exchange or market,
or other governmental body in the United States is required for the execution and delivery of this Agreement or the valid issuance
and sale of the Shares and the Warrant pursuant to this Agreement, other than such as have been or will be made or obtained, and
except for any securities filings required to be made under federal or state securities laws.

 

    2 

     

    

 

3.4.           
SEC Filings. Since January 1, 2015, the Company and its Subsidiaries have filed all reports, schedules, forms, statements
and other documents required to be filed by them with the Securities and Exchange Commission (the “Commission”)
pursuant to the reporting requirements of the Securities Exchange Act of 1934, as amended (the “Exchange Act”)
(such reports, including exhibits thereto and documents incorporated by reference therein, collectively, the “SEC Documents”).
To the best of the Company’s knowledge, as of their respective filing dates, none of the SEC Documents contained an untrue
statement of material fact or omitted to state a material fact required to be stated therein or necessary in order to make the
statements made therein, in the light and circumstances under which they were made, not misleading, except to the extent corrected
by subsequently filed or furnished SEC Documents.

 

3.5.           
Absence of Certain Changes. Except as disclosed in the SEC Documents or otherwise publicly disclosed by the Company,
since January 1, 2015, there has been no adverse change or adverse development in the business, properties, assets, operations,
financial condition, prospects, liabilities or results of operations of the Company or its Subsidiaries which, to the knowledge
of the Company, would reasonably be expected to have a Material Adverse Effect.

 

3.6.           
Capitalization. As of March 24, 2016, the authorized capital stock of the Company consists of (i) 314,800,000 shares
of Common Stock, of which 12,407,815 shares are issued and outstanding and 3,583,141 shares are issuable and reserved for issuance
pursuant to the Company’s stock option plans or securities exercisable or exchangeable for, or convertible into, shares of
Common Stock (excluding the Company’s Convertible Promissory Notes in the aggregate principal amount of $20 million issued
on October 14, 2015, as amended), and (ii) 100,000 shares of preferred stock, of which, as of the date hereof, no shares are issued.
All of such outstanding shares have been, or upon issuance will be, validly issued, fully paid and nonassessable. Except as disclosed
in the SEC Documents, as of the date hereof, (i) no shares of the Company’s capital stock are subject to preemptive rights
or any other similar rights or any liens or encumbrances suffered or permitted by the Company, (ii) there are no outstanding options,
warrants, scrip, rights to subscribe to, calls or commitments of any character whatsoever relating to, or securities or rights
convertible into, any shares of capital stock of the Company or any of its Subsidiaries, or contracts, commitments, understandings
or arrangements by which the Company or any of its Subsidiaries is or may become bound to issue additional shares of capital stock
of the Company or any of its Subsidiaries or options, warrants, scrip, rights to subscribe to, calls or commitments of any character
whatsoever relating to, or securities or rights convertible into, any shares of capital stock of the Company or any of its Subsidiaries,
(iii) there are no outstanding securities of the Company or any of its Subsidiaries which contain any redemption or similar provisions,
and there are no contracts, commitments, understandings or arrangements by which the Company or any of its Subsidiaries is or may
become bound to redeem a security of the Company or any of its Subsidiaries, and (iv) the Company does not have any stock appreciation
rights or “phantom stock” plans or agreements or any similar plan or agreement. The Company disclosed in its SEC Documents
or has furnished to Investor true and correct copies of the Company’s Tenth Amended and Restated Certificate of Incorporation,
as amended and as in effect on the date hereof (the “Certificate of Incorporation”), and the Company’s
By-laws, as amended and as in effect on the date hereof (the “By-laws”).

 

    3 

     

    

 

3.7.           
Broker. The Company has taken no action which would give rise to any claim by any person for brokerage commissions,
finder’s fees or similar payments by the Company or Investor relating to this Agreement or the transactions contemplated
hereby.

 

3.8.           
Certain Proceedings. The Company is not the subject of a voluntary bankruptcy or solvency action, has not made a
general assignment for the benefit of creditors, and has not taken any corporate action to authorize any of the foregoing.

 

4.                 
Representations, Warranties and Covenants of Investor. Investor represents and warrants to, and covenants with, the
Company as follows as of the date of this Agreement and as of the Closing Date:

 

4.1.           
Due Authorization; Organization. Investor has all requisite power, authority and capacity to execute, deliver and
perform its obligations under this Agreement, and has taken all necessary corporate, company, partnership or individual action,
as the case may be, to enter into and perform this Agreement. This Agreement has been duly authorized and validly executed and
delivered by Investor and constitutes a legal, valid and binding agreement of Investor enforceable against Investor in accordance
with its terms, except as enforceability may be limited by applicable bankruptcy, insolvency, reorganization, moratorium or similar
laws affecting creditors’ and contracting parties’ rights generally and except as enforceability may be subject to
general principles of equity (regardless of whether such enforceability is considered in a proceeding in equity or at law).

 

4.2.           
Non-Contravention. The execution and delivery of this Agreement, the purchase of the Shares and the Warrant under
this Agreement, the fulfillment of the terms of this Agreement and the consummation of the transactions contemplated hereby will
not (i) conflict with or constitute a violation of, or default (with or without the giving of notice or the passage of time or
both) under, (A) any material bond, debenture, note or other evidence of indebtedness, or under any material lease, indenture,
mortgage, deed of trust, loan agreement, joint venture or other agreement or instrument to which Investor is a party, (B) the charter,
by-laws or other organizational documents of Investor, as applicable, or (C) any law, administrative regulation, ordinance or order
of any court or governmental agency, arbitration panel or authority applicable to Investor or its property, or (ii) result in the
creation or imposition of any lien, encumbrance, claim, security interest or restriction whatsoever upon any of the material properties
or assets of Investor or an acceleration of indebtedness pursuant to any obligation, agreement or condition contained in any material
bond, debenture, note or any other evidence of indebtedness or any material indenture, mortgage, deed of trust or any other agreement
or instrument to which Investor is a party or by which Investor is bound or to which any of the property or assets of Investor
is subject. No consent, approval, authorization or other order of, or registration, qualification or filing with, any regulatory
body, administrative agency, self-regulatory organization, stock exchange or market, or other governmental body in the United States
is required for the execution and delivery of this Agreement and the purchase of the Shares and the Warrant by Investor, other
than such as have been made or obtained.

 

    4 

     

    

 

4.3.           
Private Placement. Investor represents and warrants to, and covenants with, the Company that Investor is acquiring
the Shares and the Warrant for its own account for investment only and with no present intention of distributing any of the Shares
the Warrant, or the Warrant Shares in violation of the applicable securities laws, or pursuant to any arrangement or understanding
with any other persons regarding the distribution of the Shares, the Warrant, or the Warrant Shares. Investor has been advised
and understands that none of the Shares, the Warrant, or the Warrant Shares have been registered under the Securities Act or under
the “blue sky” or similar laws of any jurisdiction and that they may be resold only if registered pursuant to the provisions
of the Securities Act and such other laws, if applicable, or, subject to the terms and conditions of this Agreement, if an exemption
from registration is available. Investor has been advised and understands that the Company, in issuing the Shares and the Warrant,
is relying upon, among other things, the representations and warranties of Investor herein in concluding that such issuance is
a “private offering” and is exempt from the registration provisions of the Securities Act.

 

4.4.           
Certain Trading Activities. Neither Investor nor any of its affiliates has directly or indirectly, nor has any person
acting on behalf of or pursuant to any understanding with Investor, engaged in any purchase or sale of Common Stock (including,
without limitation, any Short Sales (as defined below) involving the Company’s securities) since the date that Investor first
became aware of the transactions contemplated hereby. For the purposes of this Section 4.4, “Short Sales”
include, without limitation, all “short sales” as defined in Rule 200 of Regulation SHO adopted under the Exchange
Act and all types of direct and indirect stock pledges, forward sales contracts, options, puts, calls, short sales and other transactions
through non-US broker-dealers or foreign regulated brokers having the effect of hedging the securities of the Company or the investment
contemplated under this Agreement. Investor covenants that neither it, nor any person acting on its behalf or pursuant to any understanding
with it, will engage in any transaction in the securities of the Company (including short sales) prior to the filing of a Current
Report on Form 8-K, Annual Report on Form 10-K, press release, or other applicable Exchange Act report reporting this transaction.

 

4.5.           
No Advice. Investor understands that nothing in this Agreement or any other materials presented to Investor in connection
with the purchase and sale of the Shares and the Warrant constitutes legal, tax or investment advice. Investor has consulted such
legal, tax and investment advisors as it, in its sole discretion, has deemed necessary or appropriate in connection with its purchase
of the Shares and the Warrant.

 

    5 

     

    

 

4.6.         
Accredited Investor; Big Boy. Investor is an “accredited investor” as that term is defined in Rule 501(a)
of Regulation D under the Securities Act and is able to bear the risk of its investment in the Shares, the Warrant, and the Warrant
Shares. Investor has such knowledge and experience in financial and business matters that it is capable of evaluating the merits
and risks of the purchase of the Shares, the Warrant, and the Warrant Shares. Investor acknowledges that it does not have any material
non-public information relating to the Company. Investor further acknowledges that the Company and its agents, officers, directors
and affiliates possess material non-public information not known to Investor regarding or relating to the Company and/or the securities
being offered hereby, including, but not limited to, information concerning the business, financial condition, results of operations,
legal matters associated with ongoing or past litigation matters, investigations, the Company’s corporate transition matters
(including transactions related to the corporate transition matters and amounts that become payable by the Company), prospects
and other plans of the Company. Investor acknowledges that any material non-public information may be indicative of a value of
the securities being offered hereby that is substantially less than the purchase price paid by Investor, or may be otherwise adverse
to Investor, and such material non-public information, if known to Investor, could be material to Investor’s decision to
acquire the securities being offered hereby. Accordingly, Investor understands and accepts that there is an information disparity
between Investor and the Company, confirms that the Company is not obligated to disclose, and consistent with Investor’s
instructions, has not disclosed, material non-public information to Investor, and acknowledges and agrees that the Company has
no liability arising from such non-disclosure. Investor acknowledges that neither the Company nor any of its agents, officers,
directors, or affiliates has delivered any information or made any representations to Investor, except as expressly set forth herein.

 

4.7.           
Limited Representations. Investor and its advisors, if any, have been furnished with all materials relating to the
business, finances and operations of the Company and its Subsidiaries and all materials relating to the offer and sale of the Shares,
the Warrant, and the Warrant Shares, in each case that have been requested by Investor. Investor and its advisors, if any, have
been afforded the opportunity to ask such questions of the Company as they deem appropriate for purposes of the investment contemplated
hereby. Investor acknowledges and agrees that the most recent disclosure of the Company’s results is for the year ended on,
and the most recent disclosure of the Company’s financial condition is at, December 31, 2015, as reported on the Company’s
Annual Report on Form 10-K, filed with the Commission on March 22, 2016, and that, except as disclosed in the SEC Documents, no
information more recent than such date has been provided to or requested by Investor as to the Company’s results, operations,
financial condition, business or prospects. Investor understands that its purchase of the Shares, the Warrant, and, if applicable,
the Warrant Shares involves a high degree of risk and that Investor may lose its entire investment in the Shares, the Warrant,
and, if applicable, the Warrant Shares, and Investor further acknowledges and agrees that it can afford to do so without material
adverse consequences to its financial condition. Investor is not relying on, and does not have, any information provided by the
Company and its Subsidiaries, except to the extent provided in Section 3 herein.

 

4.8.           
No Recommendation. Investor understands that no United States federal or state agency or any other government or
governmental agency has passed on or made any recommendation or endorsement of the Shares, the Warrant, or the Warrant Shares or
the fairness or suitability of an investment in the Shares, the Warrant, or the Warrant Shares nor have such authorities passed
upon or endorsed the merits thereof.

 

    6 

     

    

 

4.9.           
Restrictive Legend. The Company shall issue the Warrant and certificates for the Shares and, if applicable, the Warrant
Shares to Investor with the legends described in Section 5 below.

 

4.10.       
Residence. Investor is a resident of, or is organized under the laws of, the jurisdiction set forth on the Investor’s
signature page hereto.

 

4.11.      
No Market. Investor understands that the Shares are and, upon exercise of the Warrant, the Warrant Shares will be
restricted securities, that there is no public trading market for the Warrant and that none is expected to develop, and that the
Shares, the Warrant, and the Warrant Shares must be held indefinitely unless and until the resale of such Shares, Warrant, or Warrant
Shares is registered under the Securities Act or subject to the terms and conditions of this Agreement and the applicable securities
laws, an exemption from registration is available. Investor has been advised or is aware of the provisions of Rule 144 promulgated
under the Securities Act.

 

4.12.       
No Commissions. Investor has taken no action which would give rise to any claim by any person for brokerage commissions,
finder’s fees or similar payments by the Company or Investor relating to this Agreement or the transactions contemplated
hereby.

 

4.13.       
Transactional Exemption. Investor understands that the Shares, the Warrant, and the Warrant Shares are being offered
and sold in reliance on a transactional exemption from the registration requirements of federal and state securities laws and that
the Company is relying upon the truth and accuracy of the representations, warranties, agreements, acknowledgments and understandings
of Investor set forth herein in order to determine the applicability of such exemptions and the suitability of Investor to acquire
the Shares, the Warrant, and the Warrant Shares.

 

4.14.       
Investor Undertaking. Investor understands that (i) none of the Shares, the Warrant, or the Warrant Shares may be
offered for sale, sold, assigned or transferred unless (A) subsequently registered under the Securities Act, (B) Investor shall
have delivered to the Company (if requested by the Company) an opinion of counsel to Investor, in a form reasonably acceptable
to the Company, to the effect that such Shares, Warrant, or Warrant Shares, as applicable, to be sold, assigned or transferred
may be sold, assigned or transferred pursuant to an exemption from such registration, or (C) Investor provides the Company with
reasonable assurance that such Shares, Warrant, or Warrant Shares, as applicable, can be sold, assigned or transferred pursuant
to Rule 144 or Rule 144A promulgated under the Securities Act (or a successor rule thereto) (collectively, “Rule 144”);
and (ii) any sale of the Shares, the Warrant, or the Warrant Shares, as applicable, made in reliance on Rule 144 may be made
only in accordance with the terms of Rule 144, and further, if Rule 144 is not applicable, any resale of such Shares, Warrant,
or Warrant Shares, as applicable, under circumstances in which the seller (or the Person (as defined below) through whom the sale
is made) may be deemed to be an underwriter (as that term is defined in the Securities Act) may require compliance with some other
exemption under the Securities Act or the rules and regulations of the Commission promulgated thereunder.

 

4.15.       
Disclosure of Transactions. On or before 5:30 p.m., New York time, on the fourth (4th) business day following
the date of this Agreement, the Company shall file a Current Report on Form 8-K (or other form permitted under the federal securities
law) disclosing the material terms and conditions of the transactions contemplated by this Agreement and the Warrant, in compliance
with the requirements of Form 8-K (or such other form), unless such disclosure is first provided in the Company’s Quarterly
Report on Form 10-Q.

 

    7 

     

    

 

5.                 
Stock Legend. Upon payment therefor as provided in this Agreement and/or the Warrant (as applicable), the Company
will issue to Investor the Shares and the Warrant Shares purchased by Investor.

 

Any certificate representing
the Shares shall be stamped or otherwise imprinted with a legend in substantially the following form:

 

THESE SECURITIES
HAVE NOT BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION AND MAY NOT BE OFFERED, SOLD, ASSIGNED, PLEDGED, TRANSFERRED
OR OTHERWISE DISPOSED OF EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE
“SECURITIES ACT”), OR PURSUANT TO AN AVAILABLE EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT, AND AFTER RECEIPT
BY THE COMPANY OF AN OPINION OF COUNSEL SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED UNDER THE SECURITIES
ACT OR THAT THE PROSPECTUS DELIVERY REQUIREMENTS HAVE BEEN MET.

 

Any certificate representing
the Warrant Shares issued by the Company shall also be stamped or otherwise imprinted with a legend in substantially the following
form:

 

THE SECURITIES
REPRESENTED HEREBY ARE SUBJECT TO THE RIGHTS AND OBLIGATIONS SET FORTH IN A SECURITIES PURCHASE AGREEMENT, DATED AS OF _________,
2016, BY AND BETWEEN ROCK CREEK PHARMACEUTICALS, INC. AND THE INVESTOR NAMED THEREIN, AS SUCH MAY BE AMENDED FROM TIME TO TIME.

 

The Warrant shall be
imprinted with the legends set forth in the form of Warrant attached hereto as Exhibit A.

 

The Company agrees to
issue the Shares and the Warrant Shares issued upon exercise of the Warrant, as applicable, without the legends set forth above
at such time as the Holder thereof is (i) permitted to transfer such Shares or Warrant Shares, as applicable, without restriction
pursuant to Rule 144 under the Securities Act, and upon such transfer or (ii) at such time such securities have been registered
for resale under the Securities Act, upon such resale, and subject to the undertakings in Section 4.14 hereof by Investor.

 

6.                 
Use of Proceeds. The proceeds from the sale of Shares and Warrant Shares pursuant to this Agreement shall be used
for general corporate purposes.

 

7.                 
Survival of Representations, Warranties and Agreements. Notwithstanding any investigation made by any party to this
Agreement, all covenants, agreements, representations and warranties made by the Company and Investor herein shall survive the
execution of this Agreement, the delivery to Investor of the Shares and the Warrant being purchased, and the payment therefor.

 

    8 

     

    

 

8.                 
Notices. All notices, requests, consents and other communications hereunder shall be in writing, shall be mailed
(i) if within the domestic United States, by first-class registered or certified mail, or nationally recognized overnight express
courier, postage prepaid, or by facsimile, or (ii) if delivered from outside the United States, by International Federal Express
or facsimile, and shall be deemed given (A) if delivered by first-class registered or certified mail domestic, three business days
after so mailed, (B) if delivered by nationally recognized overnight carrier, one business day after so mailed, (C) if delivered
by International Federal Express, two business days after so mailed, and (D) if delivered by facsimile, upon electric confirmation
of receipt and shall be delivered as addressed as follows:

 

(a)         
if to the Company, to:

 

Rock Creek Pharmaceuticals, Inc.

2040 Whitfield Avenue, Suite 300

Sarasota, Florida 34243

Telephone: (844) 727-0727

Attention: Chief Financial Officer

 

(b)        
if to Investor, at its address set forth on the Investor’s signature page hereto, or at such other address or addresses
as may have been furnished to the Company in writing.

 

9.                 
Changes. This Agreement may not be modified or amended except pursuant to an instrument in writing signed by the
Company and Investor.

 

10.             
Headings. The headings of the various sections of this Agreement have been inserted for convenience of reference
only and shall not be deemed to be part of this Agreement.

 

11.             
Severability. In the event that any provision contained in this Agreement is found by a court of competent jurisdiction
to be invalid, illegal or unenforceable in any respect, the validity, legality and enforceability of the remaining provisions contained
herein shall not in any way be affected or impaired thereby.

 

12.             
Governing Law. This Agreement shall be governed by, and construed in accordance with, the internal laws of the State
of New York, without giving effect to the principles of conflicts of law.

 

13.             
Entire Agreement. This Agreement constitutes the entire agreement between the parties hereto pertaining to the subject
matter hereof, and any and all other written or oral agreements relating to such subject matter are expressly cancelled.

 

14.             
Finders Fees. Neither the Company nor Investor nor any affiliate thereof has incurred any obligation which will result
in the obligation of another party to pay any finder’s fee or commission in connection with this transaction.

 

15.             
Counterparts. This Agreement may be executed in two or more counterparts, each of which shall constitute an original,
but all of which, when taken together, shall constitute one instrument, and shall become effective when one or more counterparts
have been signed by each party hereto and delivered to the other parties.

 

    9 

     

    

 

16.             
Successors and Assigns. This Agreement shall inure to the benefit of and be binding upon the successors and permitted
assigns of the Company and Investor. Investor shall not assign any rights or obligations under this Agreement other than, solely
with respect to any Shares, Warrant, or Warrant Shares transferred in accordance with this Agreement, including the legends described
herein, to any permitted transferee of such Shares, Warrant, or Warrant Shares, provided, however, that no such assignment
shall relieve Investor of its obligations under this Agreement.

 

17.             
Expenses. Each of the Company and Investor shall bear its own expenses in connection with the preparation and negotiation
of this Agreement.

 

18.             
Pronouns. All pronouns or any variations thereof shall be deemed to refer to the masculine, feminine or neuter, singular
or plural, as the identity of the person, persons, entity or entities may require.

 

[Signature pages
follow]

 

    10 

     

    

 

IN WITNESS WHEREOF, the
parties hereto have caused this Agreement to be duly executed as of the date first above written.

 

	 	ROCK CREEK PHARMACEUTICALS, INC.
	 	 	 
	 	By: 	 
	 	 	Name: Michael J. Mullan
	 	 	Title: Chairman and Chief Executive Officer

  

 

Signature Page to Securities Purchase
Agreement

 

     

     

    

 

IN WITNESS WHEREOF, the
parties hereto have caused this Agreement to be duly executed as of the date first above written.

 

	 	Name of Investor: 	 

 

	 	By:	 
	 	 	 
	 	Name:	 
	 	 	 
	 	Title:	 

 

	 	Amount of Investment: 	$	 
	 	 	 
	 	Number of Shares Purchased:  	 

 

 

Signature Page to Securities Purchase
Agreement

 

     

     

    

 

Exhibit A

 

Form of Common Stock
Purchase Warrant

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