Document:

Form of 3 1/4% Senior Subordinated Convertible Notes due 2013

 Exhibit 4.2 
  

UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY (“DTC”) TO CV THERAPEUTICS, INC. (OR ITS
SUCCESSOR) OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE, CONVERSION OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR OF SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND ANY
PAYMENT HEREON IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL SINCE THE REGISTERED OWNER
HEREOF, CEDE & CO., HAS AN INTEREST HEREIN. 
  
  

 1 

 CV THERAPEUTICS, INC. 
 31⁄4% Senior Subordinated Convertible Note due 2013 
  
 CUSIP NO. 126667AG9 
  
 $149,500,000.00 
  
 No. 2005-1

  
 CV THERAPEUTICS, INC., a Delaware corporation (the
“Company”, which term includes any successor corporation under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede & Co., or its registered assigns, the principal sum of One Hundred Forty-Nine
Million Five Hundred Thousand U.S. Dollars ($149,500,000.00) on August 16, 2013. 
  
 Interest Payment Dates: February 16 and August 16, commencing February 16, 2006. 
  
 Regular Record Dates: February 1 and August 1. 
  
 Reference is hereby made to the further provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have
the same effect as if set forth at this place. 
  
  

 2 

 IN WITNESS WHEREOF, the Company has caused this Security to be duly executed manually or by facsimile by
its duly authorized officers. 
  

									
	Dated: July 1, 2005	 	 	 	CV THERAPEUTICS, INC.
					
	 	 	 	 	 	 	By:	 	 
	 	 	 	 	 	 	 	 	 Name: Louis G. Lange, M.D., Ph.D.
 Title: Chairman and
Chief Executive Officer

					
	 	 	 	 	 	 	By:	 	 
	 	 	 	 	 	 	 	 	 Name: Dan Spiegelman
 Title: Chief Financial
Officer and Senior Vice President

  
 Trustee’s
Certificate of Authentication 
  
 This is one of the 31⁄4%
Senior Subordinated Convertible Notes due 2013 described in the within-named Indenture. 
  

									
	 	 	 	 	 WELLS FARGO BANK, NATIONAL
 ASSOCIATION, as Trustee

					
	 	 	 	 	 	 	 By:
	 	 
	 	 	 	 	 	 	 	 	 Name: Timothy P. Mowdy
 Title: Vice
President

  
 Dated: July 1, 2005 
  

 3 

 [REVERSE OF SECURITY] 
  
 CV THERAPEUTICS, INC. 
  
 31⁄4% Senior Subordinated Convertible Note due 2013 
  
 Capitalized terms used herein but not defined shall have the meanings assigned to them in the Indenture referred to below unless otherwise indicated.

  
 1. Principal and Interest. CV Therapeutics, Inc., a
Delaware corporation (the “Company”), promises to pay interest on the principal amount of this Security at the Interest Rate from the date of issuance until repayment at Maturity, redemption or repurchase. The Company shall pay interest on
this Security semiannually in arrears on February 16 and August 16 of each year (each an “Interest Payment Date”), commencing February 16, 2006. 
  
 Interest on this Security shall be computed on the basis of a 360-day year of twelve 30-day months and for any period shorter than a full semiannual
period for which interest is calculated, on the basis of a 30-day month and, for such periods of less than a month, the actual number of days elapsed over a 30-day month. 
  
 A Holder of any Security at the close of business on a Regular Record Date shall be entitled to receive interest on such
Security on the corresponding Interest Payment Date. A Holder of any Security which is converted after the close of business on a Regular Record Date and prior to the corresponding Interest Payment Date (other than any Security whose Maturity is
prior to such Interest Payment Date) shall be entitled to receive interest on the principal amount of such Security, notwithstanding the conversion of such Security prior to such Interest Payment Date. However, any such Holder which surrenders any
such Security for conversion during the period between the close of business on such Regular Record Date and ending with the opening of business on the corresponding Interest Payment Date shall be required to pay the Company an amount equal to the
interest on the principal amount of such Security so converted (but excluding any overdue interest on the principal amount of such Security so converted that exists at the time such Holder surrenders such Security for conversion), which is payable
by the Company to such Holder on such Interest Payment Date, at the time such Holder surrenders such Security for conversion. Notwithstanding the foregoing, any such Holder which surrenders for conversion any Security (a) which has been called for
redemption by the Company in a notice of redemption given by the Company pursuant to Section 10.4 of the Indenture on a Redemption Date after such Regular Record Date and on or prior to the next succeeding Interest Payment Date or (b) with respect
to which the Company has specified a Repurchase Date that is after such Regular Record Date and on or prior to the next succeeding Interest Payment Date, in either case, shall be entitled to receive (and retain) such interest and need not pay the
Company an amount equal to the interest on the principal amount of such Security so converted at the time such Holder surrenders such Security for conversion. 
  

2. Method of Payment. Interest on any Security which is payable, and is punctually paid or duly provided for, on any Interest Payment Date shall
be paid to the person in whose name that Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record Date for such interest. 
  
 Principal of, and premium, if any, and interest on, Global Securities shall be payable to the Depositary in immediately
available funds. 
  
 Principal of and premium, if any, on Physical
Securities shall be payable at the office or agency of the Company maintained for such purpose, initially the Corporate Trust Office of the Trustee. Interest on Physical Securities shall be payable by (i) U.S. Dollar check drawn on a bank located in
the city where the 
  

 4 

 Corporate Trust Office of the Trustee is located mailed to the address of the Person entitled thereto as
such address shall appear in the Register, or (ii) upon application to the Registrar not later than the relevant Record Date by a Holder of an aggregate principal amount of Securities in excess of $5,000,000, wire transfer in immediately available
funds. 
  
 3. Paying Agent and Registrar. Initially, Wells
Fargo Bank, National Association, the Trustee under the Indenture, will act as Paying Agent and Registrar. The Company may change the Paying Agent or Registrar without notice to any Holder. 
  
 4. Indenture. The Company issued this Security under an Indenture,
dated as of July 1, 2005 (the “Indenture”), between the Company and Wells Fargo Bank, National Association, as trustee (the “Trustee”). The terms of this Security include those stated in the Indenture and those made part of the
Indenture by reference to the Trust Indenture Act of 1939, as amended (“TIA”). This Security is subject to all such terms, and Holders are referred to the Indenture and the TIA for a statement of all such terms. To the extent permitted by
applicable law, in the event of any inconsistency between the terms of this Security and the terms of the Indenture, the terms of the Indenture shall control. 
  

5. Optional Redemption. This Security is not redeemable prior to August 20, 2010. This Security may be redeemed in whole or in part, upon not
less than 20 nor more than 60 days’ notice, at any time on or after August 20, 2010, at the option of the Company, at the redemption prices (expressed as a percentage of the principal amount) set forth below if redeemed during the periods
described below, plus any interest accrued but not paid prior to, but excluding, the Redemption Date. 
  

				
	Period	  	Redemption
Price

	 
	 Beginning August 20, 2010 and ending on August 19, 2011
	  	101.219	%
	 Beginning August 20, 2011 and ending on August 19, 2012
	  	100.813	%
	 Beginning on August 20, 2012 and thereafter
	  	100.406	%

  
 If fewer than all the
Securities are to be redeemed, the Trustee shall select the particular Securities to be redeemed from the Outstanding Securities by the methods as provided in the Indenture. If any Security selected for partial redemption is converted in part before
termination of the conversion right with respect to the portion of the Security so selected, the converted portion of such Security shall be deemed to be the portion selected for redemption (provided, however, that the Holder of such
Security so converted and deemed redeemed shall not be entitled to any additional interest payment as a result of such deemed redemption than such Holder would have otherwise been entitled to receive upon conversion of such Security). Securities
which have been converted during a selection of Securities to be redeemed may be treated by the Trustee as Outstanding for the purpose of such selection. 
  
 On and after the Redemption Date, interest shall cease to accrue on Securities or portions of Securities called for redemption, unless the Company
defaults in the payment of the Optional Redemption Price and accrued and unpaid interest. 
  
 Notice of redemption shall be given by the Company to the Holders as provided in the Indenture. 
  
 6. Repurchase Rights. 
  
 (a) Repurchase Right Upon a Fundamental Change. If a Fundamental Change occurs, the Holder of Securities, at the Holder’s option, shall have
the right, in accordance with the provisions of the Indenture, to require the Company to repurchase the Securities (or any portion of the principal amount hereof that is at least $1,000 or an integral multiple thereof; provided,
however, that the portion of the principal amount of this Security to be Outstanding after such repurchase is at least equal to $1,000) at a purchase price equal to 100% of the principal amount of the Securities to be repurchased (the
“Repurchase Price”), plus interest accrued and unpaid to, but excluding, the Repurchase Date. 
  

 5 

 A Company Notice shall be given by the Company to the Holders as provided in the Indenture. To exercise a
Repurchase Right, a Holder must deliver to the Trustee a written notice as provided in the Indenture. 
  
 (b) Payment of Repurchase Price. Subject to the fulfillment by the Company of the conditions set forth in the Indenture, the Company may elect to
pay the Repurchase Price by delivering the number of shares of Common Stock equal to (i) the Repurchase Price divided by (ii) 95% of the average of the daily volume-weighted average price of the Common Stock for the twenty consecutive Trading Days
immediately preceding and including the third Business Day prior to the Repurchase Date (if the third Business Day prior to the applicable Repurchase Date is a Trading Day, or if not, then on the last Trading Day prior to the third Business Day),
appropriately adjusted to take into account the occurrence, during the period commencing on the first Trading Day during the twenty Trading-Day period and ending on the Repurchase Date of any event that would result in an adjustment to the
conversion rate set forth in the Indenture. No fractional shares of Common Stock will be issued upon repurchase of any Securities. Instead of any fractional share of Common Stock which would otherwise be issued upon conversion of such Securities,
the Company shall pay a cash adjustment as provided in the Indenture. 
  
 7. Conversion Rights. (a) Subject to and upon compliance with the provisions of the Indenture, the Holder of Securities shall be entitled, at such Holder’s option, at any time before the close of business on August 20, 2013, to
convert the Holder’s Securities (or any portion of the principal amount hereof which is $1,000 or an integral multiple thereof), at the principal amount thereof or of such portion thereof, into duly authorized, fully paid and nonassessable
shares of Common Stock of the Company at the Conversion Rate in effect at the time of conversion. 
  
 (b) In the case of a Security (or a portion thereof) called for redemption, such conversion right in respect of the Security (or such portion thereof) so
called shall expire at the close of business on the Business Day immediately preceding the Redemption Date, unless the Company defaults in making the payment due upon redemption. In the case of a Fundamental Change for which the Holder exercises its
Repurchase Right with respect to a Security (or a portion thereof), such conversion right in respect of the Security (or portion thereof) shall expire at the close of business on the Business Day preceding the Repurchase Date. 
  
 Subject to certain conditions provided for in the Indenture, in certain
circumstances, a Holder may receive an amount in cash or Common Stock, at the option of the Company, equal to the Make-Whole Premium, in addition to the shares of Common Stock issuable on conversion of such Security. 
  
 (c) The Conversion Rate shall be initially equal to 37.0370 shares of Common
Stock per $1,000 principal amount of Securities. The Conversion Rate shall be adjusted under certain circumstances as provided in the Indenture. 
  
 (d) No fractional shares of Common Stock shall be issued upon conversion of any Securities. Instead of any fractional share of Common Stock which would
otherwise be issued upon conversion of such Securities, the Company shall pay a cash adjustment as provided in the Indenture. 
  
 (e) If a Fundamental Change Effective Date occurs prior to August 20, 2010, other than in connection with a Fundamental Change described in clause (3) of
the definition of “Change of Control,” and a Holder converts Securities in connection with such Fundamental Change, that Holder shall receive the Make-Whole Premium payable pursuant to Section 12.13 of the Indenture consisting of an
increase in the Conversion Rate. 
  

 6 

 8. Subordination. The Indebtedness evidenced by this Security is, to the extent and in the manner
provided in the Indenture, subordinated and subject in right of payment to the prior payment in full of all amounts then due on all Senior Debt of the Company; provided, however, that the Securities, the Indebtedness represented
thereby and the payment of the principal of and premium, if any, and interest on the Securities in all respects shall rank equally with, or prior to, all existing and future Indebtedness of the Company that is expressly subordinated to any Senior
Debt, and this Security is issued subject to such provisions of the Indenture with respect thereto. Each Holder of this Security, by accepting the same, (a) agrees to and shall be bound by such provisions, (b) authorizes and directs the Trustee on
such Holder’s behalf to take such action as may be necessary or appropriate to effectuate the subordination so provided and (c) appoints the Trustee such Holder’s attorney-in-fact for any and all such purposes. 
  
 9. Denominations; Transfer; Exchange. The Securities are issuable in
registered form, without coupons, in denominations of $1,000 and integral multiples of $1,000 in excess thereof. A Holder may register the transfer or exchange of Securities in accordance with the Indenture. The Registrar may require a Holder, among
other things, to furnish appropriate endorsements and transfer documents and the Company may require a Holder to pay any taxes and fees required by law or permitted by the Indenture. 
  
 In the event of a redemption in part, the Company shall not be required (a) to register the transfer of, or exchange,
Securities for a period of 15 days immediately preceding the date notice is given identifying the serial numbers of the Securities called for such redemption, or (b) to register the transfer of, or exchange, any such Securities, or portion thereof,
called for redemption. 
  
 In the event of redemption, conversion
or repurchase of the Securities in part only, a new Security or Securities for the unredeemed, unconverted or unrepurchased portion thereof shall be issued in the name of the Holder hereof. 
  
 10. Persons Deemed Owners. The registered Holder of this Security
shall be treated as its owner for all purposes. 
  
 11.
Unclaimed Money. The Trustee and the Paying Agent shall pay to the Company any money held by them for the payment of principal, premium, if any, or interest that remains unclaimed for two years after the date upon which such payment shall
have become due. After payment to the Company, Holders entitled to the money must look to the Company for payment as general creditors unless an applicable abandoned property law designates another Person, and all liability of the Trustee and the
Paying Agent with respect to such money shall cease. 
  
 12.
Discharge Prior to Redemption or Maturity. Subject to certain conditions contained in the Indenture, the Company may discharge its obligations under the Securities and the Indenture if (1) (a) all of the Outstanding Securities shall become
due and payable at their scheduled Maturity within one year or (b) all of the Outstanding Securities are scheduled for redemption within one year, and (2) the Company shall have deposited with the Trustee money and/or U.S. Government Obligations
sufficient to pay the principal of, and premium, if any, and interest on, all of the Outstanding Securities on the date of Maturity or redemption, as the case may be. 
  
 13. Amendment; Supplement; Waiver. The Indenture permits, with certain exceptions as therein provided, the amendment
thereof and the modification of the rights and obligations of the Company and the rights of the Holders of the Securities under the Indenture at any time by the Company and the Trustee with the consent of the Holders of a majority in aggregate
principal amount of the Outstanding Securities (or such 
  

 7 

 lesser amount as shall have acted at a meeting pursuant to the provisions of the Indenture). The
Indenture also contains provisions permitting the Holders of specified percentages in principal amount of the Securities at the time Outstanding, on behalf of the Holders of all the Securities, to waive compliance by the Company with certain
provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders of this Security
and of any Security issued upon registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation of such consent or waiver is made upon this Security or such other Security. 
  
 No reference herein to the Indenture and no provision of this Security or of
the Indenture shall alter or impair the obligation of the Company, which is absolute and unconditional, to pay the principal of and premium, if any, and interest on this Security at the times, places and rate, and in the coin or currency, herein
prescribed or to convert this Security (or pay cash in lieu of conversion) as provided in the Indenture. 
  
 14. Defaults and Remedies. The Indenture provides that an Event of Default with respect to the Securities occurs when any of the following occurs:

  
 (a) the Company defaults in the payment of the principal of or
premium, if any, on any of the Securities when it becomes due and payable, at Maturity, upon redemption or exercise of a Repurchase Right or otherwise, whether or not such payment is prohibited by the subordination provisions of Article 13 of the
Indenture; or 
  
 (b) the Company defaults in the payment of
interest on any of the Securities when it becomes due and payable and such default continues for a period of 30 days, whether or not such payment is prohibited by the subordination provisions of Article 13 of the Indenture; provided,
however, that the Company’s failure to pay interest on any of the Securities within five Business Days of any Interest Payment Date prior to and including August 16, 2008 shall constitute an immediate Event of Default; or 
  
 (c) the Company fails to deliver shares of Common Stock, together with cash
instead of fractional shares, when those shares of Common Stock or cash instead of fractional shares is required to be delivered following conversion of a Security in accordance with the provisions of Article 12 of the Indenture; or 
  
 (d) the Company fails to perform or observe any other term, covenant or
agreement contained in the Securities or the Indenture and such default continues for a period of 60 days after written notice of such failure is given as specified in the Indenture; or 
  
 (e) (i) the Company fails to make any payment by the end of the applicable grace period, if any, after the maturity of any
Indebtedness for borrowed money in an amount in excess of $5,000,000, or (ii) there is an acceleration of any Indebtedness for borrowed money in an amount in excess of $5,000,000 because of a default with respect to such Indebtedness without such
Indebtedness having been discharged or such acceleration having been cured, waived, rescinded or annulled, in the case of either clause (i) or (ii) above, for a period of 30 days after written notice is given to the Company as specified in the
Indenture; or 
  
 (f) the failure to provide the Company Notice in
accordance with the terms of Section 11.3(a) of the Indenture; or 
  
 (g) there are certain events of bankruptcy, insolvency or reorganization of the Company; or 
  

 8 

 (h) the Pledge and Escrow Agreement ceases to be in full force and effect or enforceable prior to its
expiration in accordance with its terms. 
  
 If an Event of
Default shall occur and be continuing, the principal of all the Securities may be declared due and payable in the manner and with the effect provided in the Indenture. 
  
 15. Authentication. This Security shall not be valid until the Trustee (or authenticating agent) executes the
certificate of authentication on the other side of this Security. 
  
 16. Abbreviations. Customary abbreviations may be used in the name of a Holder or an assignee, such as: TEN COM (= tenants in common), TEN ENT (= tenants by the entireties), JT TEN (= joint tenants with right of survivorship and not
as tenants in common), CUST (= Custodian) and U/G/M/A (= Uniform Gifts to Minors Act). 
  
 17. Additional Rights of Holders of Transfer Restricted Securities. In addition to the rights provided to Holders under the Indenture, Holders of Transfer Restricted Securities shall have all the rights set
forth in the Registration Rights Agreement. 
  
 18. CUSIP
Numbers. Pursuant to a recommendation promulgated by the Committee on Uniform Security Identification Procedures, the Company has caused CUSIP numbers to be printed on this Security and the Trustee may use CUSIP numbers in notices of redemption
as a convenience to Holders. No representation is made as to the accuracy of such numbers either as printed on this Security or as contained in any notice of redemption and reliance may be placed only on the other identification numbers placed
thereon. 
  
 19. Governing Law. The Indenture and this
Security shall be governed by, and construed in accordance with, the law of the State of New York. 
  
 20. Successor Corporation. In the event a successor corporation assumes all the obligations of the Company under this Security, pursuant to the
terms hereof and of the Indenture, the Company shall be released from all such obligations. 
  
  

 9 

 ASSIGNMENT FORM 
  
 To assign this Security, fill in the form below and have your signature guaranteed: (I) or (we) assign and transfer this
Security to: 
  
 (Insert assignee’s soc. sec. or tax I.D.
no.) 
  
 (Print or type assignee’s name, address and zip
code) 
  
 and irrevocably appoint to transfer this Security
on the books of the Company. The agent may substitute another to act for him. 
  

						
	Dated:	  	
	  	
	 
	 	  	Your
Name:	  	 	 
	 	  	 	  	(Print
your
name
exactly
as it
appears
on the
face of
this
Security	 
 
 
 
 
 
 
 
 
)
	 	  	Your
Signature:	  	 	 
	 	  	 	  	(Sign
exactly
as your
name
appears
on the
face of
this
Security	 
 
 
 
 
 
 
 
)

  

	
	Signature Guarantee*:
	 By:

  
 * Participant in a
recognized Signature Guarantee Medallion Program (or other signature guarantor acceptable to the Trustee). 
  
  

 10 

 CONVERSION NOTICE 
  
 TO: CV THERAPEUTICS, INC. 
  
 3172 Porter Drive 
  
 Palo Alto, California 94304 
  
 Attention: General Counsel 
  
 The undersigned registered owner of this Security hereby irrevocably exercises the option to convert this Security, or the portion hereof (which is $1,000
principal amount or an integral multiple thereof) below designated, into shares of Common Stock in accordance with the terms of the Indenture referred to in this Security, and directs that the shares issuable and deliverable upon such conversion,
together with any check in payment for fractional shares and any Securities representing any unconverted principal amount hereof, be issued and delivered to the registered holder hereof unless a different name has been indicated below. If shares or
any portion of this Security not converted is to be issued in the name of a person other than the undersigned, the undersigned will pay all transfer taxes payable with respect thereto. Any amount required to be paid to the undersigned on account of
interest accompanies this Security. 
  

							
	Dated:	  	Your Name:

	 	 	
	 
	 	  	 	 	 	(Print
your
name
exactly
as it
appears
on the
face of
this
Security	 
 
 
 
 
 
 
 
 
)
	 	  	Your
Signature:	 
 	 	 	 
	 	  	 	 	 	(Sign
exactly
as your
name
appears	 
 
 
 
 
	 	  	 	 	 	on the
face of
this
Security	 
 
 
)
	 	  	Signature
Guarantee	 
*:	 	 	 
	 	  	Social
Security or
other
Taxpayer	 
 
 
 	 	 	 
	 	  	Identification
Number:	 
 	 	 	 

  
 Principal amount to be
converted (if less than all): $              

	*	Participant in a recognized Signature Guarantee Medallion Program (or other signature guarantor acceptable to the Trustee). 

  
 Fill in for registration of shares (if to be issued) and Securities (if to be
delivered) other than to and in the name of the registered holder: 
  
 (Name) 
  
 (Street Address) 
  
 (City, State and Zip Code) 
  
  

 11 

 NOTICE OF EXERCISE OF REPURCHASE RIGHT 
  
 TO: CV THERAPEUTICS, INC. 
  
 3172 Porter Drive 
  
 Palo Alto, California 94304 
  
 Attention: General Counsel 
  
 The undersigned registered owner of this Security hereby irrevocably
acknowledges receipt of a notice from CV Therapeutics, Inc. (the “Company”) as to the occurrence of a Fundamental Change with respect to the Company and requests and instructs the Company to repay the entire principal amount of this
Security, or the portion thereof (which is $1,000 principal amount or an integral multiple thereof) below designated, in accordance with the terms of the Indenture referred to in this Security, together with interest accrued and unpaid to, but
excluding, such date, to the registered holder hereof, in cash. 
  

							
	Dated:	  	Your Name:

	 	 	
	 
	 	  	 	 	 	(Print
your
name
exactly
as it
appears
on the
face of
this
Security	 
 
 
 
 
 
 
 
 
)
	 	  	Your
Signature:	 
 	 	 	 
	 	  	 	 	 	(Sign
exactly
as your
name
appears	 
 
 
 
 
	 	  	 	 	 	on the
face of
this
Security	 
 
 
)
	 	  	Signature
Guarantee	 
*:	 	 	 
	 	  	Social
Security or
other
Taxpayer	 
 
 
 	 	 	 
	 	  	Identification
Number:	 
 	 	 	 

  
 Principal amount to be
repaid (if less than all): $ 

	*	Participant in a recognized Signature Guarantee Medallion Program (or other signature guarantor acceptable to the Trustee). 

  
  

 12 

 SCHEDULE OF EXCHANGES FOR PHYSICAL SECURITIES[1] 
  
 The following exchanges of a part of this Global Security for Physical
Securities have been made: 
  

									
	Date of Exchange	 	Amount of decrease in Principal Amount of this Global Security	 	Amount of increase in Principal Amount of this Global Security	  	Principal Amount of
this Global Security
following such
decrease (or
increase)	  	Signature of
authorized officer of
Trustee

 [1] This schedule should be included only if the Security is issued in global form. 
  

 13Pledge and Escrow Agreement, dated July 1, 2005

 Exhibit 10.1 
  
 PLEDGE AND ESCROW AGREEMENT 
  

by and among 
  
 CV THERAPEUTICS, INC., 
  
 WELLS FARGO BANK, NATIONAL ASSOCIATION, 
  
 as Trustee, 
  
 and

  
 WELLS FARGO BANK, NATIONAL ASSOCIATION, as Escrow Agent

  
 Dated as of July 1, 2005 
  
  

 PLEDGE AND ESCROW AGREEMENT 
  
 THIS PLEDGE AND ESCROW AGREEMENT (this “Agreement”), dated as of July 1, 2005, is by and among CV
Therapeutics, Inc. (the “Company”), Wells Fargo Bank, National Association, as trustee under the Indenture referred to below (the “Trustee”), and Wells Fargo Bank, National Association, in its capacity as escrow
agent (the “Escrow Agent”). 
  
 RECITALS

  
 The Company and the Trustee have entered into an
Indenture, dated as of July 1, 2005 (the “Indenture”), pursuant to which the Company will issue up to $149,500,000 in aggregate principal amount of its 31⁄4% Senior Subordinated Convertible Notes due 2013 (the
“Notes”). 
  
 The Company desires to establish an
escrow account with the Escrow Agent into which an amount equal to $15,183,594 will be, simultaneously with the original issuance of the Notes, deposited by the Company to be held and distributed in accordance with the terms and conditions set forth
herein, and the Escrow Agent is willing to establish such an account and to accept such funds in accordance with the terms hereinafter set forth. 
  
 Capitalized terms used but not defined herein shall have the meanings assigned to such terms in the Indenture. 
  
 AGREEMENT 
  
 NOW, THEREFORE, for good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the
parties hereto agree as follows: 
  
 Section 1.
Establishment of Escrow Account. The Escrow Agent shall establish on the date hereof and maintain in the Trustee’s name a “securities account” (within the meaning of Article 8 of the Uniform Commercial Code of the State of
New York as in effect from time to time (the “New York UCC”)) (the “Escrow Account”) to which there shall be immediately credited and held amounts received by the Escrow Agent from the Company in accordance with
Section 3 hereof. The funds credited to the Escrow Account shall be applied and disbursed only as provided herein. The Escrow Agent shall segregate the funds credited to the Escrow Account from its other funds held as an agent or in trust. The
Escrow Agent shall treat all property held by it in the Escrow Account as “financial assets” (as defined in Section 8-102(a)(9) of the New York UCC) in accordance with Section 8-501 (or successor section) of the New York UCC. 

 
 Section 2. Deposit to the Escrow Account; Investments. 
  
 (a) Concurrently with the execution and delivery of this Agreement, the
Company shall deliver to the Escrow Agent for deposit in the Escrow Account an amount equal to $15,183,594 (the “Escrow Funds”). All amounts to be deposited with the Escrow Agent shall be transferred by wire transfer of immediately
available funds to the following account: 
  
 WELLS FARGO BANK,
N.A. 
 ABA No.: 121000248 

  

 1 

 
Account No.: 0001038377 
 Account
Name: Corporate Trust Clearing Account 
 FFC: CV Therapeutics Pledge Account, #18068201 
 Attention: Joe Taffe 
  
 (b) Promptly following the deposit of any funds into the Escrow Account, the Escrow Agent shall invest such funds in the name of the Trustee in Government
Securities as instructed by the Company. For purposes of this Agreement, “Government Securities” shall mean (i) noncallable direct obligations of, or noncallable obligations the payment of principal of and interest on which are
unconditionally guaranteed by, the United States of America; (ii) noncallable bonds, debentures or notes issued by Federal National Mortgage Association, Government National Mortgage Association, Federal Farm Credit Banks, Federal Land Banks,
Federal Home Loan Banks, Farmers Home Administration, Federal Home Loan Mortgage Corporation or any of their successors or any other comparable federal agency hereafter created to the extent that said obligations are unconditionally guaranteed by
the United States of America; and (iii) holdings in any mutual fund or similar investment vehicle that holds only securities of the type set forth in (i) or (ii) above. Promptly following the deposit of any funds into the Escrow Account, the Company
shall provide written instructions to the Escrow Agent as to the specific Government Securities in which funds are to be invested and until such instructions are given by the Company, the Escrow Agent shall not invest such funds. All such amounts
shall remain so invested until the close of business on the Business Day prior to any withdrawal by the Escrow Agent pursuant to Section 4 hereof. All Government Securities from time to time credited to the Escrow Account constituting “security
entitlements” as defined in Section 8-102(a)(17) of the New York UCC shall be held in the name of the Trustee and in no event shall the Company be or be deemed to be the “entitlement holder” (as such term is defined in as defined in
Section 8-102(a)(7) of the New York UCC) with respect thereto. 
  
 Section 3. Security Interest. 
  
 (a) Pledge and
Assignment. The Company hereby irrevocably pledges, assigns, grants, hypothecates and sets over to the Trustee, for the equal and ratable benefit of the Holders of the Notes, a first priority continuing security interest in all of the
Company’s right, title and interest in and to all of the following whether now owned or existing or hereafter acquired or created (collectively, the “Collateral”): 
  
 (i) all funds from time to time held in the Escrow Account, including, without limitation, the Escrow Funds and all
certificates and instruments, if any, from time to time, representing or evidencing the Escrow Account or the Escrow Funds; 
  
 (ii) all investments of funds in the Escrow Account, which all shall constitute Government Securities, and whether held by or registered in the name of
the Escrow Agent and all certificates and instruments, if any, from time to time representing or evidencing any such Government Securities; 
  
 (iii) all promissory notes, certificates of deposit, deposit accounts, checks and other instruments evidencing such Government Securities from time to
time hereafter delivered to or otherwise possessed by the Escrow Agent, for or on behalf of the Company, in substitution for or in addition to any or all of the then existing Collateral; 
  

 2 

 (iv) all interest, dividends, cash, instruments, securities and other property from time to time
received, receivable or otherwise distributed in respect of or in exchange for any or all of the then existing Collateral; and 
  
 (v) all proceeds of the foregoing including, without limitation, all cash proceeds and all non-cash proceeds thereof. 
  
 The Trustee hereby appoints the Escrow Agent to act as the Trustee’s
agent, on behalf of the Holders of the Notes, for purposes of perfecting the foregoing pledge, assignment and security interest in the Collateral, and the Escrow Agent hereby accepts such appointment. For so long as the foregoing pledge, assignment
and security interest remains in effect, the Escrow Agent hereby waives any right of setoff or banker’s lien that it, in its individual capacity or in its capacity as an agent for Persons other than the Trustee and the Holders of the Notes, may
have with respect to any or all of the Collateral. 
  
 (b)
Secured Obligations. This Agreement secures the due and punctual payment and performance of all obligations of the Company, whether now or hereafter existing, under the Notes, the Indenture and this Agreement, including, without limitation,
interest and premium, if any, accrued on the Notes after the commencement of a bankruptcy, reorganization or similar proceeding involving the Company to the extent permitted by applicable law (collectively, the “Secured
Obligations”). 
  
 (c) Delivery of Collateral. All
certificates or instruments, if any, representing or evidencing all or any portion of the Collateral shall be held by the Escrow Agent on behalf of the Trustee pursuant hereto and shall be in suitable form for transfer by delivery, or shall be
accompanied by duly executed instruments of transfer or assignments in blank, all in form and substance reasonably satisfactory to the Trustee, and all in form and substance sufficient to convey a valid security interest in such Collateral to the
Trustee. All securities in uncertificated or book-entry form and all security entitlements, if any, in each case representing or evidencing the Collateral shall be registered in the name of the Trustee (or any of its nominees) as the registered
owner thereof, by book-entry or as otherwise appropriate so as to properly identify the interest of the Trustee therein. In addition, the Trustee shall have the right, at any time following the occurrence of an Event of Default, to transfer to or to
register in the name of the Trustee or any of its nominees any or all other Collateral. Except as otherwise provided herein, all Collateral shall be deposited and held in the Escrow Account. The Escrow Agent shall have the right at any time to
exchange certificates or instruments representing or evidencing all or any portion of the Collateral for certificates or instruments of smaller or larger denominations in the same aggregate amount. 
  
 (d) Maintaining the Escrow Account. So long as this Agreement is in
full force and effect: 
  
 (i) subject to the other terms and
conditions of this Agreement, all Collateral held by the Escrow Agent pursuant to this Agreement shall be held in the Escrow Account, which shall be subject to the exclusive dominion and control of the Trustee for the benefit of the Trustee and the
equal and ratable benefit of the Holders of the Notes; 
  

 3 

 (ii) the Escrow Account and all Collateral from time to time therein shall remain segregated from all
other funds or other property otherwise held by the Trustee or the Escrow Agent, as applicable; 
  
 (iii) all amounts (including, without limitation, any Escrow Funds or interest on or other proceeds of the Escrow Funds or any Government Securities held
in the Escrow Account) shall remain on deposit in the Escrow Account until withdrawn in accordance with this Agreement; and 
  
 (iv) the Escrow Agent shall take all steps necessary to ensure that the Trustee is the holder or entitlement holder (as the case may be) of all of the
Collateral and that either the Trustee for the equal and ratable benefit of the Holders of the Notes or, to the extent required by applicable law, the Escrow Agent, for the benefit of the Trustee and the equal and ratable benefit of the Holders of
the Notes, is the holder or entitlement holder of all Government Securities and other uncertificated securities on the books of the applicable Federal Reserve Bank or other applicable securities intermediary. 
  
 (e) Further Assurances. Prior to, contemporaneously herewith, and at
any time and from time to time hereafter, the Company shall, at the Company’s expense, execute and deliver to the Trustee or its designee such other instruments and documents, and take all further action as the Trustee deems reasonably
necessary or advisable or may reasonably request to confirm or perfect the security interest of the Trustee granted or purported to be granted hereby or to enable the Trustee to exercise and enforce its rights and remedies hereunder with respect to
any Collateral, and the Company shall take all necessary action to preserve and protect the security interest created hereby as a first priority, perfected lien and encumbrance upon the Collateral. 
  
 (f) Transfers and Other Liens. The Company agrees that it shall not
(i) sell, assign (by operation of law or otherwise) or otherwise dispose of, or grant any option with respect to, any of the Collateral or (ii) create or permit to exist any Lien upon or with respect to any of the Collateral, except for the security
interest under Section 3 of this Agreement. 
  
 Section 4.
Distributions from Escrow Account. Funds (or Government Securities that are scheduled to mature or that can be liquidated on or before the date of the applicable Scheduled Interest Payment) on deposit in the Escrow Account shall be
withdrawn by the Escrow Agent and transferred only in accordance with this Section 4: 
  
 (a) Event of Default. 
  
 (i) For
so long as an Event of Default has occurred and is continuing under the Indenture, no amounts shall be disbursed from the Escrow Account, except as provided in clause (ii) below. 
  
 (ii) If (A) any Event of Default has occurred and is continuing under Section 4.1 of the Indenture, (B) any other Event of
Default has occurred and is continuing that 

  

 4 

 
results in the acceleration of the payment of principal, interest, premium, if any, pursuant to the terms of the Indenture, or (C) any material breach or
violation of any representation, warranty or agreement contained in this Agreement has occurred: 
  
 (I) The Trustee may, without notice to the Company except as required by applicable law and at any time or from time to time, direct the Escrow Agent to
liquidate all Collateral and transfer all proceeds thereof to the Paying Agent to apply such funds in accordance with Section 4.2 of the Indenture. 
  
 (II) The Trustee (and/or the Escrow Agent at its direction and on its behalf) may also, in addition to the other rights and remedies provided for herein,
exercise in respect of the Collateral all the rights and remedies of a secured party upon default under the New York UCC, and may also, without notice except as specified below, sell the Collateral or any part thereof in one or more parcels at
public or private sales, at any of the Trustee’s or the Escrow Agent’s offices or elsewhere, for cash, on credit or for future delivery, and upon such other terms as the Trustee may deem commercially reasonable. The Company agrees that, to
the extent notice of sale shall be required by law, at least twenty (20) days’ notice to the Company of the time and place of any public sale or the time after which any private sale is to be made shall constitute reasonable notification. The
Trustee and the Escrow Agent shall not be obligated to make any sale of Collateral regardless of notice of sale having been given. The Trustee and/or the Escrow Agent on its behalf may adjourn any public or private sale from time to time by
announcement at the time and place fixed therefor, and such sale may, without further notice, be made at the time and place to which it was so adjourned. 
  
 (III) Any cash held by the Escrow Agent as Collateral and all net cash proceeds received by the Trustee or the Escrow Agent in respect of any sale or
liquidation of, collection from, or other realization upon all or any part of the Collateral may, in the discretion of the Trustee, be held by the Trustee or the Escrow Agent as collateral for, and then or at any time thereafter be applied (after
payment of any costs and expenses incurred in connection with any sale, liquidation or disposition of or realization upon the Collateral and the payment of any amounts payable to the Trustee or the Escrow Agent) in whole or in part by the Trustee
for the equal and ratable benefit of the Holders of the Notes against all or any part of the Secured Obligations in such order as described in Section 4.13 of the Indenture. 
  
 (b) Scheduled Interest Payments. Pursuant to the Notes and Section 2.1 of the Indenture, the Company is obligated to
make payments of interest on the Notes on each of February 16, 2006, August 16, 2006, February 16, 2007, August 16, 2007, February 16, 2008 and August 16, 2008 (each, a “Scheduled Interest Payment”). The Scheduled Interest Payments
due on the Notes may be made, at the election of the Company, from (1) amounts held in the Escrow Account in accordance with the procedures set forth in subsection (i) below or (2) other sources of funds available to the Company, as anticipated in
subsection (ii) below, or from any combination of (1) and (2) above; provided, however, that nothing herein shall be construed as limiting the Company’s obligation to make all interest payments due on the Notes at the times and in the
amounts required by the Notes, which obligation shall be absolute and unconditional. 
  
 (i) Payment of Interest. If the Company elects to cause a Scheduled Interest Payment to be made using funds held in the Escrow Account, then, not later than five (5) 

  

 5 

 
Business Days prior to the date of the applicable Scheduled Interest Payment, the Company shall direct the Escrow Agent in writing to transfer from the
Escrow Account to the Paying Agent funds (or Government Securities that are scheduled to mature or that can be liquidated on or before the date of the applicable Scheduled Interest Payment) necessary to provide for payment in full (or, if the
Company intends to make a portion of such interest payment with funds or Government Securities in the Escrow Account and the remainder of such interest payment with funds other than those in the Escrow Account, such portion) of the next Scheduled
Interest Payment on the Notes. At or prior to 1:00 p.m., New York City time, on the day that is no later than one (1) Business Day following receipt of such notice, the Escrow Agent shall transfer such funds (or such Government Securities, as
applicable) to the Paying Agent as set forth in paragraph (e)(ii) hereof, and shall notify the Company in writing that it has made such transfer to the Paying Agent. If the Company does not intend to utilize the funds (or Government Securities) in
the Escrow Account to make any such Scheduled Interest Payment in full, or does not direct the Escrow Agent in writing to make any such Scheduled Interest Payment, then the Company shall make the Scheduled Interest Payment from Company Funds (as
defined in Section 4(b)(ii) below). 
  
 (ii) Release of Funds
to the Company Due to Direct Payment of Interest by the Company. If the Company makes any Scheduled Interest Payment or a portion of any Scheduled Interest Payment from a source of funds other than the Escrow Account (“Company
Funds”), the Company may, after payment in full of such Scheduled Interest Payment and upon at least five (5) Business Days prior notice, direct the Escrow Agent, so long as no Event of Default has occurred and is continuing, to release to
the Company (or at the direction of the Company, to release to a designated third party) an amount of funds or Government Securities from the Escrow Account, the sum of the cumulative interest payments on and aggregate principal amount of which is
less than or equal to the amount of Company Funds so expended in making the Scheduled Interest Payment. Upon receipt of such notice, the Escrow Agent shall pay over or transfer to the Company the requested amount. 
  
 (c) Investment Income. Subject to the provisions of Sections 3 and
4(a) above, all investment income earned on amounts on deposit in the Escrow Account is the personal property of the Company. Subject to the provisions of Section 9(b) hereof, promptly following receipt of any investment income earned on amounts on
deposit in the Escrow Account, the Escrow Agent shall transfer such funds to the Company pursuant to Section 4(e)(i) hereof. 
  
 (d) Excess Escrow Funds. If, in the course of funding the Escrow Account pursuant to Section 2(a) hereof, the Company either elects or is required
to deposit in the Escrow Account funds in an amount greater than that which is required to fund the payment of the Scheduled Interest Payments (in order to permit the Escrow Agent to purchase an amount of Government Securities equal to or greater
than that which is required to fund the payment of the Scheduled Interest Payments or otherwise) (any such excess amounts being hereinafter referred to as “Excess Escrow Funds”), the Company may, upon at least five (5) Business Days
prior written notice, direct the Escrow Agent, so long as no Event of Default has occurred and is continuing, to release to the Company (or at the direction of the Company, to release to a designated third party) an amount of funds or Government
Securities from the Escrow Account, the sum of the cumulative interest payments on and aggregate principal amount of which is less than or equal to the amount of the Excess Escrow Funds. Upon receipt of such notice, the Escrow Agent shall pay over
or transfer to the Company the requested amount. 
  

 6 

 (e) Wire Transfer. 
  
 (i) All funds distributed from the Escrow Account to the Company shall be transferred by wire transfer of immediately
available funds to the following account: 
  
 WELLS FARGO BANK, N.A. 
  
 Attn: Jim
Nelson, WF Institutional Trust & Custody 
 Routing transit# : 121000248 
 BNF: Trust Wire Clearing 
 BNFA: 0000840245 
 OBI: FFC: CV Therapeutics 
 SEI a/c# 10126300 
  
 (ii) All funds (or Government Securities that are scheduled to mature or that can be liquidated on or before the date of the applicable Scheduled Interest
Payment) distributed from the Escrow Account to the Paying Agent for payment on the Notes shall be transferred by an account-to-account transfer of immediately available funds to the following account: 
  
 WELLS FARGO BANK, N.A. 
 ABA No.: 121000248 
 Account No.: 0001038377 
 Account Name: Corporate Trust Clearing Account 
 FFC: CV Therapeutics, Inc. Convertible Notes, #18068200 
 Attention: Joe Taffe 
  
 (f) Written Instructions; Certificates. The Company shall, upon request by the Escrow Agent, execute and deliver to the Escrow Agent such
additional written instructions and certificates hereunder as may be reasonably required by the Escrow Agent to give effect to this Section 4. 
  
 Section 5. Termination of Security Interest. Upon payment in full of the Scheduled Interest Payments, the security interest evidenced by
this Agreement in any Collateral remaining in the Escrow Account shall automatically terminate and be of no further force and effect. Furthermore, upon the release of any Collateral from the Escrow Account in accordance with the terms of this
Agreement, whether upon release of such Collateral to Holders of Notes as payment of interest on the Notes, to the Company pursuant to Sections 4(b)(ii) or 4(c) or otherwise, the security interest evidenced by this Agreement in such Collateral so
released shall automatically terminate and be of no further force and effect. The Trustee and the Escrow Agent shall, upon request by the Company, execute and deliver to the Company such additional written instructions and certificates hereunder as
may be reasonably required by the Company to give effect to this Section 5. 
  

 7 

 Section 6. Attorneys-in-Fact. The Company hereby irrevocably appoints each of the Trustee
and the Escrow Agent as the Company’s attorney-in-fact, coupled with an interest, with full authority in the place and stead of the Company and in the name of the Company or otherwise, from time to time in the Trustee’s or the Escrow
Agent’s discretion to take any action and to execute any instrument that the Trustee or the Escrow Agent may deem necessary or advisable to accomplish the purposes of this Agreement, including, without limitation, to receive, endorse and
collect all instruments made payable to the Company representing any interest payment, dividend or other distribution in respect of the Collateral or any part thereof and to give full discharge for the same, and the expenses of the Trustee and the
Escrow Agent incurred in connection therewith shall be payable by the Company. 
  
 Section 7. Trustee or Escrow Agent May Perform. Without limiting the authority granted under Section 6 hereof, if the Company fails to perform any agreement contained herein, the Trustee or the Escrow
Agent may, but shall not be obligated to, itself perform, or cause performance of, such agreement, and the expenses of the Trustee or the Escrow Agent incurred in connection therewith shall be payable by the Company and shall be secured by the
Collateral. 
  
 Section 8. Representations, Warranties and
Agreements. 
  
 (a) The Company represents, warrants and agrees
that: 
  
 (i) The execution, delivery and performance by the
Company of this Agreement is within its corporate power, has been duly authorized by all necessary corporate action of the Company, and does not contravene, or constitute a default under, any provision of applicable law or regulation or of any
agreement, judgment, injunction, order, decree or other instrument binding upon the Company (except as would not, individually or in the aggregate, have a Material Adverse Effect (as defined in the Purchase Agreement)), or of the certificate of
incorporation or bylaws of the Company or result in the creation or imposition of any Lien on any assets of the Company other than the Lien contemplated hereby. 
  

(ii) The Company has full corporate power and authority to enter into this Agreement and has the right to vote, pledge and grant a security interest in
the Collateral as provided by this Agreement. 
  
 (iii) This
Agreement has been duly executed and delivered by the Company and constitutes a legal, valid and binding obligation of the Company, enforceable against the Company in accordance with its terms. 
  
 (iv) Upon the execution and delivery of this Agreement by the parties hereto
and the delivery to the Escrow Agent of the Collateral, the pledge of the Collateral pursuant to this Agreement creates a valid and perfected first priority security interest in the Collateral, securing the payment of the Secured Obligations for the
benefit of the Trustee, the Escrow Agent and the Holders of the Notes, enforceable as such against all creditors of the Company and any persons purporting to purchase any of the Collateral from each of them. 
  
 (v) No consent of any other person and no consent, authorization, approval,
or other action by, and no notice to or filing with, any governmental authority or regulatory body is required either (i) for the pledge by the Company of the Collateral pursuant to 
  
  

 8 

 
this Agreement or for the execution, delivery or performance of this Agreement by each of them or (ii) for the exercise by the Trustee or the Escrow Agent of
the remedies in respect of the Collateral pursuant to this Agreement. 
  
 (vi) No litigation, investigation or proceeding of or before any arbitrator or governmental authority is pending or, to the best knowledge of the Company, threatened by or against the Company or against any of its properties or revenues
with respect to this Agreement or any of the transactions contemplated hereby. 
  
 (vii) The pledge of the Collateral pursuant to this Agreement is not prohibited by any applicable law or governmental regulation, release, interpretation or opinion of the Board of Governors of the Federal Reserve
System or other regulatory agency (including, without limitation, Regulations T, U and X of the Board of Governors of the Federal Reserve System). 
  
 (viii) All information set forth herein relating to the Collateral is accurate and complete in all material respects. 
  
 (b) The Escrow Agent represents, warrants and agrees that: 
  
 (i) The Escrow Agent is a “bank” within the meaning of Section
9-102(a)(8) of the New York UCC. 
  
 (ii) The Escrow Agent is a
“securities intermediary” within the meaning of Section 8-102(a)(14) of the New York UCC. 
  
 (c) The Trustee represents, warrants and agrees that it is an “entitlement holder” within the meaning of Section 8-102(a)(7) of the New York
UCC. 
  
 Section 9. Fees and Expenses of Escrow Agent. 

 
 (a) The Company agrees to pay the Escrow Agent its agreed-upon
compensation for its services as Escrow Agent hereunder promptly upon request therefor, and to reimburse the Escrow Agent for all reasonable and documented expenses of or disbursements incurred by the Escrow Agent in the performance of its duties
hereunder, including the reasonable fees, expenses and disbursements of legal counsel to the Escrow Agent. 
  
 (b) The Escrow Agent shall have a lien upon any investment income on deposit in the Escrow Account solely for any costs, expenses and fees that may arise
hereunder and may retain that portion of the investment income in the Escrow Account equal to such unpaid amounts, until all such costs, expenses and fees have been paid. 
  
 Section 10. Rights, Duties and Immunities of Escrow Agent. Acceptance by the Escrow Agent of its duties under
this Agreement is subject to the following terms and conditions, which all parties to this Agreement hereby agree shall govern and control the rights, duties and immunities of the Escrow Agent: 
  

 9 

 (a) The duties and obligations of the Escrow Agent shall be determined solely by the express provisions
of this Agreement and the Escrow Agent shall not be liable except for the performance of such duties and obligations as are specifically set out in this Agreement. The Escrow Agent shall not be required to inquire as to the performance or
observation of any obligation, term or condition under any agreement or arrangement between the Company and the Trustee. The Escrow Agent is not a party to, and is not bound by, any agreement or other document out of which this Agreement may arise.
The Escrow Agent shall be under no liability to any party hereto by reason of any failure on the part of any party hereto (other than the Escrow Agent) or any maker, guarantor, endorser or other signatory of any document or any other person to
perform such person’s obligations under any such document. The Escrow Agent shall not be bound by any waiver, modification, termination or rescission of this Agreement or any of the terms hereof, unless evidenced by a writing delivered to the
Escrow Agent signed by the proper party or parties and, if the duties or rights of the Escrow Agent are affected, unless it shall give its prior written consent thereto. This Agreement shall not be deemed to create a fiduciary relationship between
the parties hereto under state or federal law. 
  
 (b) The Escrow
Agent shall not be responsible in any manner for the validity or sufficiency of this Agreement or of any property delivered hereunder, or for the value or collectibility of any note, check or other instrument, if any, so delivered, or for any
representations made or obligations assumed by any party other than the Escrow Agent. Nothing herein contained shall be deemed to obligate the Escrow Agent to deliver any cash, instruments, documents or any other property referred to herein, unless
the same shall have first been received by the Escrow Agent pursuant to this Agreement. 
  
 (c) The Company shall reimburse and indemnify the Escrow Agent for, and hold it harmless against, any loss, liability or expense, including but not limited to reasonable legal counsel fees, incurred without bad faith,
gross negligence or willful misconduct on the part of the Escrow Agent, arising out of or in conjunction with its acceptance of, or the performance of its duties and obligations under, this Agreement, as well as the costs and expenses of defending
against any claim or liability arising out of or relating to this Agreement. 
  
 (d) The Escrow Agent shall be fully protected in acting on and relying upon any written notice, direction, request, waiver, consent, receipt or other paper or document which the Escrow Agent in good faith believes to
have been signed and presented by the Company. 
  
 (e) The Escrow
Agent shall not be liable for any error of judgment, or for any act done or step taken or omitted by it in good faith or for any mistake in act or law, or for anything which it may do or refrain from doing in connection herewith, except its own
gross negligence or willful misconduct. 
  
 (f) The Escrow Agent
may seek the advice of legal counsel in the event of any dispute or question as to the construction of any of the provisions of this Agreement or its duties hereunder, and except for its own bad faith, gross negligence or willful misconduct it shall
incur no liability and shall be fully protected in respect of any action taken, omitted or suffered by it in good faith in accordance with the advice or opinion of such counsel. 
  

 10 

 (g) The parties hereto agree that if the Escrow Agent is notified by the Trustee, the Company or the
Holders of the Notes of any dispute with respect to the payment, ownership or right of possession of the Escrow Account, the Escrow Agent is authorized and directed to retain in its possession, without liability to anyone, except for its bad faith,
willful misconduct or gross negligence, all or any part of the Escrow Account until such dispute shall have been settled either by mutual agreement by the parties concerned or by the final order, decree or judgment of a court or other tribunal of
competent jurisdiction in the United States of America, and a notice executed by the parties to the dispute or their authorized representatives shall have been delivered to the Escrow Agent setting forth the resolution of the dispute. The Escrow
Agent shall be under no duty whatsoever to institute, defend or partake in such proceedings. 
  
 (h) The agreements set forth in this Section 10 shall survive the resignation or removal of the Escrow Agent, the termination of this Agreement and the payment of all amounts hereunder. 
  
 Section 11. Resignation or Removal of Escrow Agent. 
  
 (a) The Escrow Agent shall have the right to resign upon 30 days’ prior
written notice to the Company and the Trustee. The Company shall have the right to remove the Escrow Agent upon 30 days’ prior written notice to the Escrow Agent and the Trustee. In the event of such resignation or removal, the Company shall
appoint a successor escrow agent hereunder by delivering to the Escrow Agent a written notice of such appointment. Upon receipt of such notice, the Escrow Agent shall deliver to the designated successor escrow agent all money and other property held
hereunder and shall thereupon be released and discharged from any and all further responsibilities whatsoever under this Agreement; provided, however, that the Escrow Agent shall not be deprived of its compensation earned prior to such time.

  
 (b) If no successor escrow agent shall have been designated by
the date specified in the Escrow Agent’s notice, all obligations of the Escrow Agent hereunder shall nevertheless cease and terminate. The Escrow Agent’s sole responsibility thereafter shall be to keep safely all property then held by it
and to deliver the same to a person designated by the other parties hereto or in accordance with the direction of a final order or judgment of a court of competent jurisdiction. 
  
 Section 12. Miscellaneous. 
  

(a) Waiver. No waiver of any provision of this Agreement nor consent to any departure by any party therefrom shall in any event be effective
unless the same shall be in writing and signed by each of the non-breaching parties and then such waiver or consent shall be effective only in the specific instance and for the specific purpose for which given. 
  
 (b) Severability. If, for any reason whatsoever, any one or more of
the provisions of this Agreement shall be held or deemed to be inoperative, unenforceable or invalid in a particular case or in all cases, such circumstances shall not have the effect of rendering any of the other provisions of this Agreement
inoperative, unenforceable or invalid, and the inoperative, unenforceable or invalid provision shall be construed as if it were written so as to effectuate, to the maximum extent possible, the parties’ intent. 
  

 11 

 (c) Binding Effect. This Agreement shall inure to and be binding upon the parties and their
respective successors and permitted assigns; provided, however, that the Company may not assign its rights or obligations hereunder without the express prior written consent of the Trustee. 
  
 (d) Choice of Law. The existence, validity, construction, operation
and effect of any and all terms and provisions of this Agreement shall be determined in accordance with and governed by the internal laws of the State of New York including, without limitation the New York UCC, without giving effect to the conflicts
of law principles of such State. The securities intermediary’s jurisdiction for purposes of Section 8-110 of the New York UCC shall be the State of New York. 
  
 (e) Entire Agreement. This Agreement, the Purchase Agreement, the Notes and the Indenture contain the entire
agreement among the parties with respect to the subject matter hereof and supersede any and all prior agreements, understandings and commitments with respect thereto, whether oral or written; provided, however, that this Agreement is executed
and accepted by the Trustee and the Escrow Agent subject to all terms and conditions of its acceptance of the trust under the Indenture, as fully as if said terms and conditions were set forth at length herein. 
  
 (f) Amendments. This Agreement may be amended only by a writing signed
by duly authorized representatives of all parties. The Trustee and the Escrow Agent may execute an amendment to this Agreement only if the requisite consent of each of the Holders of the Notes required by Article VII of the Indenture has been
obtained, unless no such consent is required by such Section 7.1 of the Indenture. 
  
 (g) Notices. All notices, requests, instructions, orders and other communications required or permitted to be given or made under this Agreement to any party hereto shall be delivered in writing by hand
delivery or overnight delivery, or shall be delivered by facsimile or telephonically with machine confirmation of full delivery not more than 24 hours following such facsimile or telephonic notice. A notice given in accordance with the preceding
sentence shall be deemed to have been duly given upon the sending thereof. Notices should be addressed as follows: 
  
 To the Company: 
  
 CV Therapeutics, Inc. 
 3172 Porter Drive 
 Palo Alto, California 94304 
 Attention: General Counsel 
 Facsimile number: (650) 858-0388 
 Telephone number: (650) 384-8611 
  
  

 12 

 With a copy (which shall not constitute notice) to: 
  
 Latham & Watkins LLP 
 135 Commonwealth Drive 
 Menlo Park, California 94025 
 Attention: Alan C. Mendelson, Esq. 
 Facsimile number: (650) 463-4639 
 Telephone number: (650) 328-4600 
  
 To the Trustee or the Escrow Agent: 
  
 Wells Fargo Bank, National Association 
 Corporate Trust Services 
 MAC N9303-120 
 Sixth and Marquette Avenue 
 Minneapolis, Minnesota 55479 
 Attention: Tim Mowdy 
 Facsimile number: (612) 667-9825 
 Telephone number: (612) 316-1445 
  
 or at such other address, facsimile number or phone number as the specified
entity most recently may have designated in writing in accordance with this paragraph to the other parties. 
  
 (h) Counterparts. This Agreement may be executed in one or more counterparts, each of which shall be deemed an original but all of which together
shall constitute one and the same instrument. Delivery of an executed counterpart of a signature page to this Agreement by facsimile shall be effective as delivery of a manually executed counterpart of this Agreement. 
  
 (i) Interpretation. The headings of the sections contained in this
Agreement are solely for convenience or reference and shall not affect the meaning or interpretation of this Agreement. 
  
 [Signature pages follow] 
  
  

 13 

 IN WITNESS WHEREOF, the parties hereto have executed and delivered this Agreement as of the day first
written above. 
  

					
	CV THERAPEUTICS, INC.
			
	By:	 	 	 	 
	 	 	 Name:
	 	 Louis G. Lange, M.D., Ph.D.

	 	 	 Title:
	 	 Chairman and Chief Executive Officer

	
	WELLS FARGO BANK, NATIONAL
ASSOCIATION, as Trustee
			
	By:	 	 	 	 
	 	 	 Name:
	 	 Timothy P. Mowdy

	 	 	 Title:
	 	 Vice President

	
	WELLS FARGO BANK, NATIONAL
ASSOCIATION, as Escrow Agent
			
	By:	 	 	 	 
	 	 	 Name:
	 	 Timothy P. Mowdy

	 	 	 Title:
	 	 Vice President

  

 14

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00087-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00087-of-00352.parquet"}]]