Document:

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                              EMPLOYMENT AGREEMENT

      THIS EMPLOYMENT AGREEMENT (the "Agreement") by and between AMICAS, Inc., a
Delaware corporation ("Company"), and Peter McClennen (the "Executive"), is
hereby entered into, and effective, as of the 28th day of March, 2005 (the
"Effective Date").

      WHEREAS, Company is engaged in the business of providing radiology and
medical image and information management, administrative and practice management
solutions, products and related services (the "Business"); and

      WHEREAS, the Executive desires to be employed by Company and Company
desires to employ and assure itself of the continued services of the Executive
on the terms and conditions set forth herein.

      NOW, THEREFORE, in consideration of the mutual promises, terms, covenants
and conditions set forth herein and the performance of each, it is hereby agreed
as follows:

      1.    Employment and Duties & Compensation and Benefits.

            A. The Executive hereby accepts employment and agrees to undertake
the duties and responsibilities inherent in his position and such other duties
and responsibilities as the Board of Directors or its designee shall from time
to time reasonably assign to him.

NOTWITHSTANDING ANYTHING HEREIN TO THE CONTRARY THIS AGREEMENT IS SUBJECT TO AND
CONDITIONED UPON EXECUTIVE RELOCATING TO THE BOSTON MASSACHUSETTS AREA AND
WORKING FULL TIME FROM THE COMPANY'S BOSTON MASSACHUSETTS OFFICE. FAILURE TO DO
SO ON OR BEFORE OCTOBER 1, 2005 SHALL BE DEEMED "CAUSE" PURSUANT SECTION 3A OF
THE AGREEMENT.

The Executive agrees to devote his entire business time, attention and energies
to the business and interests of Company during the Term. Neither the foregoing
nor any other provision of this Agreement is intended or shall be construed as
preventing the Executive from devoting his time and effort as a board member or
senior advisor to another business noncompetitive to the Business, provided that
such involvement with such activities does not materially interfere with the
performance of his duties under this Agreement. The Executive agrees to abide by
the rules, regulations, instructions, personnel practices and policies of the
Company and any changes therein that may be adopted from time to time by the
Company.

            B. Vacation. Vacation time, which shall never be less than the
number of weeks granted for calendar year 2005, shall be taken at such time as
not to materially interfere with the Business of Company. One week of any unused
vacation time for a calendar year may be carried forward to the next calendar
year only.
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            C. Compensation & Duties. The job title, compensation and other
employment terms of the Executive are specified in the annexed Exhibit 1, which
is incorporated into, and made a part of, this Agreement.

            D. Non-Compete and Non-Disclosure. The Non-Compete and
Non-Disclosure Agreement executed by the Executive and annexed as Exhibit 2 is
incorporated into, and made a part of, this Agreement.

            E. Indemnification. The Executive shall be indemnified and held
harmless by Company to the greatest extent permitted under Delaware law as the
same now exists or may hereafter be amended (but, in the case of any such
amendment, only to the extent that such amendment permits Company to provide
broader indemnification than was permitted prior to such amendment) and under
Company's by-laws as such exist on the Effective Date, if the Executive is or
was made, or is threatened to be made, a party to any pending, completed or
threatened action, suit, arbitration, alternative dispute resolution mechanism,
investigation, administrative hearing or any other proceeding whether civil,
criminal, administrative or investigative, and whether formal or informal, by
reason of the fact that the Executive is or was, or had agreed to become, a
director, officer, employee, agent, or fiduciary of Company or any other entity
which the Executive is or was serving at the request of Company ("Proceeding").
Such indemnification shall be against all expenses (including all reasonable
attorneys' fees (including any fees for separate counsel so chosen by the
Executive), retainers, court costs, transcripts, fees of experts, witness fees,
travel expenses, duplicating costs, printing and binding costs, telephone
charges, postage, delivery service fees, and all other reasonable disbursements
or expenses customarily required in connection with asserting or defending
claims) ("Expenses") and all claims, damages, liabilities and losses (including
judgments, fines, and liabilities under the Internal Revenue Code or the
Employee Retirement Income Security Act of 1974, as amended, for damages, excise
taxes or penalties; damages, fines or penalties arising out of violation of any
law related to the protection of the public health, welfare or the environment;
and amounts paid or to be paid in settlement) incurred or suffered by the
Executive or to which the Executive may become subject for any reason.

                  (i) Advancement of Expenses and Costs. All Expenses incurred
by or on behalf of the Executive in defending or otherwise being involved in a
Proceeding shall be paid by Company in advance of the final disposition of a
Proceeding, including any appeal therefrom, within 30 days after the receipt by
Company of a statement or statements from the Executive requesting such advance
or advances from time to time. Such statement or statements shall evidence the
Expenses incurred by the Executive in connection therewith, together with
supporting invoices, receipts and other documentation.

                  (ii) Effect of Certain Proceedings. The termination of any
Proceeding by judgment, order, settlement or conviction, or upon a plea of nolo
contendere or its equivalent, except, in each case, to the extent that the terms
thereof expressly so provide, shall not, of itself (i) adversely affect the
rights of the Executive to indemnification, or (ii) create a presumption that
the Executive did not meet any

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particular standard of conduct or have any particular belief or that a court has
determined that indemnification or contribution is not permitted by applicable
law.

                  (iii) Other Rights to Indemnification. The Executive's rights
of indemnification and advancement of Expenses provided by this Section 1E shall
not be deemed exclusive of any other rights to which the Executive may now or in
the future be entitled under applicable law, the certificate of incorporation,
by-laws, agreement, vote of stockholders, or resolution of the Board of
Directors, or other provisions of this Agreement or any other agreement, or
otherwise.

                  (iv) Representations. Company represents and warrants that
this Section 1E does not conflict with or violate its certificate of
incorporation or by-laws, and agrees that it will not amend its certificate of
incorporation or by-laws in a manner that would limit the rights of the
Executive hereunder. Company represents that the execution, delivery and
performance of this Agreement has been duly and validly authorized by the Board
of Directors.

                  (v) Survival of Indemnity. Notwithstanding anything in this
Agreement to the contrary, this Section 1E shall survive any termination of the
relationship of the Executive with Company and shall be binding on, and inure to
the benefit of the successors and assigns of Company and the successors,
assigns, heirs and personal representatives of the Executive.

                  (vi) Company agrees to maintain appropriate Directors' and
Officers' Liability Insurance.

      2. Term. The term of employment of the Executive under this Agreement
shall be for a period beginning on the Start Date (defined as the earlier of
April 21, 2005 or the date after Executive resigns from his position with his
current employer and commences employment with the Company) and ending on
December 31, 2005 ("Initial Period"), subject to earlier termination as provided
in Section 3; provided, however, that at the end of such Initial Period and each
anniversary date thereafter, the term of this Agreement will automatically be
extended for an additional year unless, not less than ninety (90) days prior to
the end of such Initial Period or one (1) year extension period, as the case may
be, Company or the Executive shall have given written notice that it or he
elects not to have the term extended. The term of this Agreement as extended and
defined by this section shall be referred to as the "Term."

      3.    Early Termination.

            A. For Cause.

                  (i) Notwithstanding the foregoing, Company may terminate the
employment of the Executive "for Cause" (as hereinafter defined) at any time
upon written notice effective immediately. For purposes of this Agreement,
"Cause" shall mean that, prior to any termination pursuant to this Section 3.A.,
the Executive shall have committed:

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                  (1) An intentional act or acts of fraud, embezzlement or theft
constituting a felony and resulting or intended to result directly in gain or
personal enrichment for the Executive at the expense of Company, or the
conviction of the Executive of, or the entry of a pleading of guilty or nolo
contendere by the Executive to any felony involving moral turpitude;

                  (2) The continued, repeated, intentional and willful refusal
to perform the duties associated with the Executive's position with Company,
which is not cured within thirty (30) days following written notice to the
Executive; provided, however, that the Executive's refusal to take any action
that he reasonably believes violates any applicable law or regulation or
fiduciary duty, shall not constitute grounds for the application of this
subsection (2); or

                  (3) A material breach of the Executive's obligations under
this Agreement, which is not cured within fifteen (15) days following written
notice to the Executive. Voluntary termination of employment by the Executive at
any time shall not constitute a material breach of this Agreement.

            The Executive shall not be deemed to have been terminated for
"Cause" hereunder unless and until there shall have been delivered to the
Executive a copy of a resolution duly adopted by the affirmative vote of not
less than a majority of the Board of Directors of Company then in office at a
meeting of the Board called and held for such purpose, after reasonable notice
to the Executive and an opportunity for the Executive, together with his counsel
(if the Executive chooses to have counsel present at such meeting), to be heard
before the Board, finding that, in the good faith opinion of the Board, the
Executive had committed an act constituting "Cause" as herein defined and
specifying the particulars thereof in detail. Nothing herein will limit the
right of the Executive or his beneficiaries to contest the validity or propriety
of any such determination.

            The Board of Directors of the Company must be advised prior to the
delivery of any notice sent pursuant to either Section (2) or (3) above.

                  (ii) Upon termination of the Executive's employment for Cause,
Company shall have no further obligation to pay any salary, bonus, or other
compensation or benefits to the Executive for periods after the effective date
of the termination for Cause, except for Base Salary and other benefits that
accrued or are payable under applicable law as of the termination date. In
addition, the right to exercise any vested stock option shall terminate on the
90th day following the effective date of the termination of employment for
Cause.

            B. Change in Control. If, after a Change in Control (as hereinafter
defined) of the Company, within twelve (12) months either the Company or the
Executive elects to terminate the employment of the Executive, the terminating
party shall give the other party thirty (30) days prior written notice of such
termination and thereafter the Company shall pay to the Executive as severance
pay the Executive's then current monthly Base Salary, in accordance with the
Company's normal payroll procedures, for

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eighteen (18) months from the termination date, in exchange for the Executive's
execution and non-revocation of the Release (as hereinafter defined). The
Executive acknowledges that, except as otherwise provided by law, he shall not
have any right to receive any additional financial compensation other than the
severance pay referenced in the previous sentence and the COBRA payments
described herein; provided, however, that he thereafter shall retain any and all
rights to receive reimbursement for all reimbursable Company expenses and
compensation for all equity or other interests that he may then retain in the
Company pursuant to this Agreement. In addition, in exchange for the Executive's
execution and non-revocation of the Release, Company shall pay the COBRA
insurance premiums for medical and dental insurance for the Executive and his
family for eighteen months following the Executive's termination date, provided
that the Executive elects and remains eligible for such coverage. All COBRA
premiums after the eighteen month period shall be paid solely by the Executive.

      The term "Release" means the document attached hereto as Exhibit 3;
provided, however, that the severance benefits provided in the Release shall be
governed by the terms of this Agreement.

      The term "Change in Control" means:

                  (i) The acquisition by any person, entity or "group" within
the meaning of Sections 13(d)(3) or 14(d)(2) of the Securities Exchange Act of
1934 ("34 Act") (excluding, for this purpose, Company, any of its subsidiaries,
or any employee benefit plan of Company or any of its subsidiaries) of
beneficial ownership (within the meaning of Rule 13d-3 promulgated under the 34
Act) of more than forty percent (40%) of either the then outstanding shares of
common stock of Company or of the combined voting power of Company's then
outstanding voting securities entitled to vote generally in the election of
directors;

                  (ii) Individuals who, as of the date hereof, constitute the
board of directors of Company ("Incumbent Board") cease for any reason to
constitute at least a majority of the board of directors, provided that any
individual becoming a director subsequent to the date hereof whose election, or
nomination for election by Company's shareholders, was approved by a vote of at
least a majority of the directors then comprising the Incumbent Board shall be
considered as though such individual is a member of the Incumbent Board; or

                  (iii) Approval of the shareholders of Company of a merger,
consolidation or other reorganization in each case, with respect to which
persons who were the shareholders of Company and options immediately prior to
such merger, consolidation or other reorganization, immediately thereafter, do
not own more than sixty percent (60%) of the combined voting power entitled to
vote generally in the election of directors of the merged, consolidated or
reorganized Company's then outstanding voting securities, or of the sale of all
or substantially all of the assets of Company; provided, however, in such event
the Change in Control will be deemed to have occurred immediately prior to the
merger, consolidation or other reorganization.

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      Gross-Up Payment. If any of the payments made to the Executive under this
Section 3.B ("payments") will be subject to the tax imposed by Section 4999 of
the Internal Revenue Code of 1986, as amended (the "Code") the ("Excise Tax"),
(and/or any similar tax that may be imposed by federal, state or local law),
Company shall pay to the Executive an additional amount (the "gross-up payment")
equal to the sum of (x) the Excise Tax imposed on the payments, (y) the Excise
Tax imposed on the gross-up payment, and (z) the federal, state and local income
taxes imposed upon the gross-up payment. The gross-up payment shall be made
within 45 days after the date of termination. For purposes of determining
whether any of the payments will be subject to the Excise Tax and the amount of
such Excise Tax, any other payments or benefits received or to be received by
the Executive in connection with a Change in Control or the Executive's
termination (whether pursuant to the terms of this Agreement or any other plan,
arrangement or agreement with Company, any person whose actions result in a
Change in Control or any person affiliated with Company or such person) shall be
treated as "parachute payments" within the meaning of Section 280G(b)(2) of the
Code, and all "excess parachute payments" within the meaning of Section
280G(b)(1) shall be treated as subject to the Excise Tax, unless in the opinion
of tax counsel selected by Company and acceptable to the Executive, such other
payments or benefits (in whole or in part) do not constitute parachute payments,
or such excess parachute payments (in whole or in part) represent reasonable
compensation for services actually rendered within the meaning of Section
280G(b)(4) of the Code, or are otherwise not subject to the Excise Tax. For
purposes of determining the amount of the gross-up payment, the Executive shall
be deemed to pay federal, state and local income taxes at the highest marginal
rate of federal, state and local income taxation in the calendar year in which
the gross-up payment is to be made in the state and locality of the Executive's
residence on the date of termination, net of the maximum reduction in federal
income taxes which could be obtained from deduction of any state and local
income taxes. In the event that the Excise Tax is subsequently determined to be
less than the amount used to calculate the gross-up payment, the Executive shall
repay to Company at the time that the reduction in Excise Tax is finally
determined the portion of the gross-up payment attributable to such reduction,
plus interest on the amount of such repayment at the rate provided in Section
7872(f)(2) of the Code. In the event that the Excise Tax is determined to exceed
the amount used to calculate the gross-up payment (including by reason of any
payment the existence or amount of which cannot be determined at the time of the
gross-up payment), Company shall make an additional gross-up payment in respect
of such excess (plus any interest payable with respect to such excess) at the
time that the amount of such excess is finally determined.

      For purposes of this Agreement, a termination of the Executive's
employment shall be deemed to have occurred after a Change in Control (even if
actual termination occurs prior to a Change in Control), if such termination
occurs at any time after the commencement of a process or negotiations that
culminates in an actual Change in Control. Accordingly, if any rights or
benefits of the Executive are terminated or modified as of the date of such
actual termination, such rights or benefits shall be reinstated, restored or
recalculated on a retroactive basis after such Change in Control.

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            C. Non-Renewal by Company, Termination by Company without Cause, or
Termination by the Executive upon Good Reason Before a Change in Control or More
Than Twelve Months After a Change in Control, or Termination Due to the
Executive's Death or Disability at Any Time.

      Provided that the Executive executes and does not revoke the Release, the
Executive shall be entitled to the severance benefits set forth in this Section.
In the event:

(a) Company elects not to renew this Agreement before a Change in Control or
more than twelve months after a Change in Control,

(b) Company terminates the employment of the Executive without Cause before a
Change in Control or more than twelve months after a Change in Control, or

(c) the Executive terminates his employment for Good Reason before a Change in
Control or more than twelve months after a Change in Control, then

            (w) Company shall pay to the Executive as severance pay, the
            Executive's then current monthly Base Salary, which during the Term
            shall not be reduced, in accordance with the Company's normal
            payroll procedures, for the remainder of the Term and an additional
            twelve (12) months from the end of the Term; and

            (x) Company shall pay the COBRA insurance premiums for medical and
            dental insurance for the Executive and his family for the remainder
            of the Term and an additional twelve (12) months from the end of the
            Term, provided that the Executive elects and remains eligible for
            such coverage. All COBRA premiums after the twelve (12) months
            period shall be paid solely by the Executive; and

            (y) if Company achieves the targeted goals for the fiscal year set
            forth in Exhibit 1 only, then the Executive shall receive the
            benefits provided therein, if any, including a bonus and the vesting
            of any performance based stock options all as described in Exhibit
            1. Company shall pay the Executive the bonus at the time bonuses are
            paid to other executives, but not later than the next January 31st
            following the Executive's last day of employment. The rights to
            exercise any vested performance based stock options shall terminate
            on the ninety (90) day anniversary following the date the Executive
            is notified by Company that the targeted goals were met;

      In the event the Executive's employment terminates due to his death or
Total and Permanent Disability (as defined below), Company shall provide to the
Executive or any

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other assignee as provided in Section 5 below, the same rights, payments and
benefits he would have received if he was terminated as set forth in Section 3.C
above.

For purposes of this Agreement, a termination of the Executive's employment
shall be deemed to have occurred after a Change in Control, if such termination
occurs at any time after the commencement of a process or negotiations that
culminates in an actual Change in Control.

            D. For purposes of this Agreement, termination by the Executive for
"Good Reason" shall mean any of the events set forth below, which are not cured
within fifteen (15) days following written notice thereof by the Executive to
Company, and which were not agreed to in writing by the Executive:

                  (i) Any reduction in compensation including Base Salary,
rights, payments and benefits of the Executive under this Agreement;

                  (ii) A material reduction in the Executive's job function,
authority, titles, duties or responsibilities;

                  (iii) Any material breach of any of the terms of this
Agreement by Company; or

                  (iv) A required relocation of the Executive's office location
of more than forty (40) miles from the Company's current headquarters location
as set forth in Section 7;

            E. For purposes of this Agreement, the term "Total and Permanent
Disability" shall mean the suffering by the Executive of a Disability (defined
below) for a continuous period in excess of one hundred eighty (180) days. A
Total and Permanent Disability shall be deemed to commence upon the expiration
of such one hundred eighty (180) day period.

                        For purposes hereof, the terms "Disabled" or
"Disability" shall mean a mental or physical condition which renders the
Executive unable or incompetent to carry out the material job responsibilities,
with or without reasonable accommodation, which such the Executive held or the
material duties to which the Executive was assigned after the time the
disability was incurred. A determination of disability shall be made by a
physician mutually agreed upon by Company and the Executive (which agreement
neither party shall unreasonably withhold); provided that if the Executive and
Company cannot agree on a physician, the Executive and Company shall each select
a physician and these two shall select a third physician, whose determination as
to disability shall be binding on all parties.

            F. The Company and the Executive agree that the stock options
granted pursuant to Exhibit 1 of this Agreement, were made pursuant to Company's
1996 and/or 2000 Stock Option Plans ("Option Plans") and, except as set forth
herein, are subject to the terms and conditions of the Option Plans.

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            G. In the event the Executive terminates his employment without Good
Reason or by notice of nonrenewal at any time, the Executive acknowledges that
he shall not have any right to receive salary, bonus or any other compensation
or other employee benefits beyond the termination date, except as provided by
law and for the Executive's rights with respect to any retirement savings,
equity compensation or similar benefits plans, including those referenced under
section 3F above which rights and benefits the Executive shall continue to have
and maintain.

            H. The severance payments, COBRA payments and any obligation to pay
a bonus ("Severance") as may be set forth in Sections 3B and 3C above are
subject to termination or reduction as follows
      (i) In addition to any other rights the Company may have, any obligation
for the Company to pay Severance to Executive shall immediately terminate as of
the date the Executive becomes employed by a Competitor as defined in the
Non-Compete and Non-Disclosure Agreement (Exhibit 2) and in violation of the
Non-Compete and Non-Disclosure Agreement; and

      (ii) Any obligation for the Company to pay Severance to Executive shall
immediately be reduced by one-half as of the date the Executive becomes
employed, other than on a short term or part time basis, by any entity that is
either i) not a Competitor or ii) a Competitor but such employment is not in
violation of the Non-Compete and Non-Disclosure Agreement.

Executive agrees to notify the Company in writing upon his acceptance of
employment following termination during any applicable severance period.

      4. No Mitigation Obligation. The payment of any termination compensation
by Company to the Executive in accordance with the terms of this Agreement is
hereby acknowledged by Company to be reasonable, and the Executive will not -
except as set forth in section 3H above- be required to mitigate the amount of
any payment provided for in this Agreement by seeking other employment or
otherwise, nor - except as set forth in section 3H above-will any profits,
income, earnings or other benefits from any source whatsoever create any
mitigation, offset, reduction or any other obligation on the part of the
Executive hereunder or otherwise.

      5. Assignment; Binding Effect. The rights and obligations of Company shall
inure to the benefit of and shall be binding upon the successors and assigns of
Company. The rights and obligations of the Executive are not assignable except
that the right to receive all rights, payments and benefits under this Agreement
shall inure to the benefit of the Executive's spouse, estate, representatives,
heirs, administrators, successors and/or assigns in the event of the Executive's
death (collectively, "third party beneficiaries").

      6. Complete Agreement. This Agreement hereby supersedes any other
employment agreements or understandings, written or oral, between Company and
the Executive. This written Agreement is the final, complete and exclusive
statement and expression of the agreement between Company and the Executive and
of all the terms of this Agreement, and it cannot be varied, contradicted or
supplemented by evidence of any

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prior or contemporaneous oral or written agreements. This written Agreement may
not be later modified except by a further writing signed by a duly authorized
officer of Company and the Executive, and no term of this Agreement may be
waived except by writing signed by the party waiving the benefit of such term.
Moreover, should there be any contradiction or conflict between the terms of
this Agreement and the terms of any Exhibit annexed hereto (other than Exhibit 3
which is not effective until executed) and/or any other document, the terms of
this Agreement shall govern.

      7. Notice. Whenever any notice is required hereunder, it shall be given in
writing addressed as follows:

      To Company:                       AMICAS, Inc.
                                        20 Guest St.
                                        Boston, MA 02135
                                        Attention:  General Counsel

      To the Executive:                 Peter McClennen
                                        1042 Pine Street
                                        Winnetka, IL  60093

Notice shall be deemed given by the deposit in the U.S. Mail of a writing
addressed as above and sent first class mail, certified, return receipt
requested, by personal delivery, or by overnight delivery, and shall be deemed
effective when actually received. Either party may change the address for notice
by notifying the other party of such change in accordance with this Agreement;
provided, however, that, in addition to any such designated address of the
Executive, the Company shall also send the Executive any such notice to his
then-current or last-known address shown on the Company's payroll records.

      8. Severability; Headings. If any portion of this Agreement is held
invalid or inoperative, the other portions of this Agreement shall be deemed
valid and operative and, so far as is reasonable and possible, effect shall be
given to the intent manifested by the portion held invalid or inoperative. This
Agreement shall be enforced separately and independently of any other agreement
involving the parties hereto. The Section headings herein are for reference
purposes only and are not intended in any way to describe, interpret, define or
limit the extent or intent of the Agreement or of any part hereof.

      9. Governing Law. This Agreement shall be interpreted and construed by the
laws of the State of Massachusetts, without regard to conflict of laws
provisions. The Executive hereby irrevocably submits to and acknowledges and
recognizes the jurisdiction of the courts of the State of Massachusetts, or if
appropriate, a federal court located in the State of Massachusetts (which
courts, for purposes of this Agreement, are the only courts of competent
jurisdiction), over any suit, action or other proceeding arising out of, under
or in connection with this Agreement or the subject matter hereof.

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      10. Counterparts. This Agreement may be executed simultaneously in two (2)
or more counterparts, each of which shall be deemed an original and all of which
together shall constitute, but one and the same instrument.

      11. Legal Fees. The Executive shall be entitled to receive prompt
reimbursement for all reasonable and necessary legal costs and expenses (not to
exceed $5,000) incurred by the Executive in the connection with the review and
negotiation of this Agreement and its exhibits.

      IN WITNESS WHEREOF, the parties hereto have set their hand and seal to
this Agreement and executed it as of the day and year first above written.

                                    COMPANY:

                                    AMICAS, Inc.

                                    By:   ______________________
                                          Kenneth R. Adams
                                    Its:  Chairman of the Compensation
                                    Committee of the Board of Directors

                                    EXECUTIVE:

                                    ______________________________
                                    Peter McClennen

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                                    EXHIBIT 1
          TO EXECUTIVE'S EMPLOYMENT AGREEMENT ("EMPLOYMENT AGREEMENT")
                            AMICAS, INC. ("COMPANY")

Executive:              Peter McClennen
Position:               Chief Operating Officer ("COO") & President#
Auto Allowance:         $12,000.00 annual; paid semi-monthly
Status:                 Exempt
Manager:                CEO
Optional Benefits:      Health, dental, life, and disability
                        401(k) savings plan
                        Employee stock purchase plan
                        4 weeks vacation
Annual Salary:          2005: $260,000
                        2006: $275,000

                                          #subject to Board of Director approval
EXECUTIVE INCENTIVE COMPENSATION PLAN:

A. ADDITIONAL COMPENSATION
      Option Grant #1: You will receive option rights to purchase 300,000 shares
      of Company common stock priced at the market value per share of the
      Company's common stock at the close of the NASDAQ National Market on the
      grant date of option grant #1 which shall be the date your appointment as
      COO is effective.
      Vesting: Option shares shall vest and become exercisable, provided
      Executive is employed by Company, as follows: i) 100,000 shall vest one
      year from grant date of option grant #1, and ii) the balance shall vest in
      eight equal quarterly installments beginning twelve months from grant date
      of option grant #1 so that the first quarterly installment shall vest
      fifteen months after the date of the grant. Incentive Stock Options
      ("ISOs"): Using the Company's 1996 Stock Option Plan, to the extent
      permitted, option shares shall be ISOs. All other option shares shall be
      from the Company's 2000 Broad-Based Stock Plan. Terms: Except as set forth
      below and in your Agreement, these option shares shall terminate ten years
      from the grant date of Option Grant #1 and, other than as described in
      your Agreement and herein, shall be subject to the terms and conditions of
      the Company's 1996 Stock Option Plan. Please note the following:

      -  Upon termination* of employment, one half of all then unvested Option
         Grant #1 options shall immediately fully vest and your right to
         exercise any and all vested Option Grant #1 stock options shall
         terminate on the earlier of 1 year from termination or ten years from
         the date of grant. All other unvested options shall be canceled.
      -  Upon a Change in Control all unvested Option Grant #1 stock options
         shall fully vest and the exercise period shall terminate on the earlier
         of two years from termination or ten years from the date of grant.
      -  Upon termination of employment by the Company for Cause or your
         voluntary termination all unvested Option Grant #1 stock options shall
         be canceled.
      -  Upon termination of employment for any other reason including death or
         Total and Permanent Disability, but excluding any termination by the
         Company without Cause (handled above), for Cause (handled above) or
         your voluntary termination (handled above), all unvested Option Grant
         #1 options shall immediately fully vest and your right to exercise any
         and all vested Option Grant #1 stock options shall terminate on the
         earlier of 1 year from termination or ten years from the date of grant.
      -  Upon your voluntary termination, as described in section 3G of the
         Agreement, all vested stock options will continue for five years from
         date of termination.
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      Cash Bonus #1. $75,000 to be paid no later than 30 days after the Start
      Date. Executive agrees that, upon either a voluntary termination (other
      than as a result of a Change in Control) or termination for Cause as
      described in the Agreement, within seven (7) months of the Start Date,
      Executive must repay this Cash Bonus #1 to AMICAS.

      Cash Bonus #2. Up to $75,000 may be earned subject to the Company's
      standard 2005 management Bonus plan.

B. PERFORMANCE BASED COMPENSATION

      1. OPTION GRANT #2- PERFORMANCE BASED STOCK OPTIONS:
      i) You will receive option rights to purchase 300,000 shares of Company
         common stock priced at the market value per share of the Company's
         common stock at the close of the NASDAQ National Market on the Option
         Grant #2 Date which shall be the date your appointment as COO is
         effective. All these option rights shall be subject to the terms and
         conditions of the Employment Agreement, and to the extent it does not
         conflict with the Employment Agreement, the Company's 2000 Broad-Based
         Stock Plan except for the vesting of such options upon Change in
         Control (as defined in the Employment Agreement) which shall be
         governed by the terms herein.
         o  All 300,000 option shares will vest and become exercisable on the
            sixth anniversary of the Option Grant #2 Date. However, subject to
            attainment of Share Goals (described below), the vesting of a
            certain percentage of these shares will accelerate.
         o  If there is a Change in Control (as defined in the Employment
            Agreement) all of these option shares shall immediately vest.
         o  If you are terminated pursuant to paragraph 3C of the Employment
            Agreement or because of Death or Total and Permanent Disability in
            either 2005 or 2006, and the Share Goal for the year you were
            terminated is thereafter achieved, the unvested Grant #2 option
            shares for the applicable Share Goal year only shall vest as set
            forth below and you shall have two (2) years from the date of your
            termination to exercise such options as to these vested option
            shares.
         o  Unvested stock options will also vest if termination* of your
            employment occurs before or after the target measuring period, and
            the applicable goals for the target measuring period are met.
         o  Upon your voluntary termination, as described in section 3G of the
            Agreement, all vested stock options will continue for two (2) years
            from date of termination.
         o  While you are employed, all vested options will continue for ten
            (10) years from date of grant. Upon termination* all vested options
            shall expire five (5) years from date of termination of employment.
            Upon your death or Total and Permanent Disability, as defined in
            section 3E of the Agreement, all vested options shall expire two (2)
            years from date of death or Total and Permanent Disability.
         o  Upon either i) your voluntary termination, as described in section
            3G of the Agreement, or ii) termination for Cause as defined in the
            Agreement, , then all unvested stock options shall be canceled and
            unexercisable.

      2. SHARE GOALS:-
            2005: Subject to the attainment of an Average Stock Price (defined
      as the average daily closing Company stock price on the NASDAQ National
      Market for the applicable calendar year) of $4.00 to $5.00 per share for
      the calendar year 2005, a percentage (determined by straight line
      interpolation) of 150,000 of the option shares will vest and become
      exercisable effective December 31, 2005 (if acceleration of all 150,000
      shares is not earned in 2005, there will be a carry over to 2006 of any
      remaining unvested
<PAGE>
      option shares). Example: if the Average Stock Price for 2005 equates to
      $4.50, vesting would accelerate with respect to 50% or 75,000 option
      shares of the option grant as of December 31, 2005; the balance of 75,000
      option shares would rollover to 2006.
            2006**: Subject to the attainment of an Average Stock Price of $5.00
      to $6.00 per share for the calendar year 2006, a percentage (determined by
      straight line interpolation) of the sum of (i) the option shares that
      remained unvested as of December 31, 2005 plus (ii) an additional 150,000
      will vest and become exercisable effective December 31, 2006 (if
      acceleration of all 300,000 shares is not earned before or in 2006, there
      will be a carry over to 2007 of any remaining unvested option shares).
      Example: if there are 225,000 option shares remaining as described in the
      example above (150,000 + 75,000), and if the Average Stock Price for 2006
      equates to $5.50, vesting will accelerate with respect to an additional
      112,500 option shares as of December 31, 2006.
            2007**. Subject to the attainment of an Average Stock Price of $6.00
      to $7.00 per share for the calendar year 2007, a percentage (determined by
      straight line interpolation) of the sum of the option shares that remained
      unvested as of December 31, 2006 will vest and become exercisable
      effective December 31, 2007. There shall be no carryover for 2008. Any
      remaining unvested option shares would cliff vest on the sixth anniversary
      of the Option Grant #2.
            If necessary (e.g. stock split), the Share Goals shall be adjusted
      in a manner similar to the terms of section 13 of the 2000 Broad-Based
      Stock Plan.

      3. CASH BONUS #3:
            2005: up to $75,000 may be earned subject to Share Goals for 2005
      described above except there will be no rollover to the following year nor
      cliff vesting. (e.g. if the Average Stock Price for 2005 equates to $4.50,
      a $37,500 bonus will be paid)
            All bonuses will be calculated in a manner consistent with that
      related to Option #2 (that is, straight line interpolation related to
      stock price) except that no rollover from 2005 to 2006 will be provided).
      Cash bonuses, if any, will be paid within thirty (30) days of the end of
      the applicable calendar year.
            2006**: up to $75,000 may be earned subject to Share Goals for 2006
      described above except there will be no rollover to the following year nor
      cliff vesting.

            * for `non renewal', `good reason' and `termination without cause'-
            as set forth in paragraph 3C (a) through (c) of the Agreement.
            ** THE CASH BONUS, GOALS AND OPTION VESTING FOR 2006 ARE APPLICABLE
            ONLY IN THE EVENT THE AGREEMENT IS STILL IN EFFECT AS OF JANUARY 1,
            2006 AND OTHERWISE SHALL BE VOID AND OF NO FORCE AND EFFECT. THE
            CASH BONUS FOR 2007 IS APPLICABLE ONLY IN THE EVENT THE AGREEMENT IS
            STILL IN EFFECT AS OF JANUARY 1, 2007 AND OTHERWISE SHALL BE VOID
            AND OF NO FORCE AND EFFECT.

C. RELOCATION EXPENSES.
      The Company shall reimburse Executive up to $80,000 in costs incurred by
      Executive in relocating Executive and his family to the Boston, MA area in
      connection with real estate transaction costs, temporary housing, travel,
      storage, moving, mileage and incidental expenses related to your
      relocation in accordance with the Company's T&E policy including
      submission of written receipts for such costs. Executive agrees that, upon
      either a voluntary termination (other than as a result of a Change in
      Control) or termination for Cause as described in the Agreement, within
      twelve (12) months of the date of his relocation, Executive must repay
      AMICAS for all relocation expenses reimbursed- such repayment to be made
      within 30 days of his last day of employment.
<PAGE>
D. Other Terms
  1 Effectiveness. This Exhibit 1 is effective on the Effective Date provided it
  is signed by the Executive and the Chairman of the Compensation Committee of
  the Board of Directors. Except as may be set forth in the Employment
  Agreement, this plan is not a contract of employment and does not guarantee
  continued employment for any period. None of the incentive amounts specified
  in this plan may be earned until the end of the applicable time period. Earned
  incentive amounts are payable only upon review and approval by the
  Compensation Committee. There will be no incentive amounts earned for
  partial-year results upon the voluntary or involuntary termination of the
  Executive's employment before December 31, 2005, unless otherwise specified in
  the Employment Agreement with the Company. This plan does not amend or
  supersede the Employment Agreement. All cash bonuses will be paid less
  applicable withholding for taxes and other amounts required by law to be
  withheld.

  2. Company Discretion. Except with respect to the calculation and amount of
  cash bonuses, the Option Grants, the Share Goals and the related Option
  Accelerations and only to the extent it does not conflict with the Employment
  Agreement, the Compensation Committee reserves the right to revise this plan
  at any time as a result of its sole determination that a significant change in
  circumstances or extraordinary or unusual event, transaction (e.g., an
  acquisition), charge and/or credit has occurred or was incurred, that was not
  anticipated or factored into this plan when this plan was signed.

  3. Options- Miscellaneous terms: Notwithstanding anything herein to the
  contrary: i) in no event shall the exercise period for any option extend
  beyond 10 years from the date of grant of such option; and ii) upon your
  termination for Cause (as defined in section 3A of the Agreement), all
  unvested stock options are canceled, and all vested stock options shall have
  an exercise period, and shall expire, ninety (90) days from date of
  termination.

----------------------------              ---------------------
Peter McClennen                           Date

----------------------------              ----------------------
Compensation Committee Chairman           Date<PAGE>

                                                                   EXHIBIT 10.25

                         STANDARD FORM COMMERCIAL LEASE

                            Steven D. Rosenberg as Trustee of the Fifth Street
1.   PARTIES                Realty Trust of 300 Bent Street, Cambridge, MA 02141
     (fill in)
                            LESSOR, which expression shall include his heirs,
                            successors, and assigns where the context so admits,
                            does hereby lease to Biogen, Inc., a corporation
                            having its mailing address at 14 Cambridge Center,
                            Cambridge, MA 02142

                            LESSEE, which expression shall include its
                            successors, executors, administrators, and assigns
                            where the context so admits, and the LESSEE hereby
                            leases the following described premises:

2.   PREMISES               The land consisting of approximately 11,809 square
     (fill in and include,  feet as shown on the deed survey map attached hereto
     if applicable, suite   as Exhibit "A", together with the entire building
     number, floor number,  thereon known and numbered as 190 Fifth Street,
     and square feet)       Cambridge, MA consisting of approximately 17,000
                            square feet as shown on the attached schematic maps
                            attached hereto as Exhibit "B".

                            xxx

3.   TERM                   The term of this lease shall be for Fourteen (14)
     (fill in)              years and seven (7) months commencing on June 1,
                            1990 and ending on December 31, 2004, unless earlier
                            terminated pursuant to paragraph 4A below.

4.   RENT                   The LESSEE shall pay to the LESSOR rent [ILLEGIBLE]
     (fill in)              as follows: [ILLEGIBLE]

      THIS LEASE SHALL BE TREATED AS A SO-CALLED "TRIPLE NET LEASE"

                                SCHEDULE OF RENT

      a)    Base rent of $164,000.00 per year, payable in advance in monthly
            installments of $13,666.66.

      b)    Commencing as of June 1, 1992 and each June 1 thereafter, the base
            rent shall be increased by an amount equal to 5% of the prior
            year's base rent.

      c)    The LESSEE shall pay to the LESSOR, within 30 days of invoice by the
            LESSOR together with a copy of the respective bills or invoices, the
            real estate taxes, premiums for insurance coverage and water and
            sewer charges incurred by the LESSOR for the premises during the
            term of this Lease. LESSOR shall send such bills to LESSEE at 14
            Cambridge Center, Cambridge, MA 02142, Attention Accounts Payable.
            The LESSEE reserves the right to appeal real estate taxes and
            receive benefit of abatements if any. The LESSEE reserves the right
            to secure and pay for comparable insurance coverage itself.

      4A.   Premature Termination:

            a)    After the expiration of eight (8) years the LESSEE may
                  prematurely terminate this Lease providing to the LESSOR a
                  written notice sent not less than one (1) year in advance of
                  the effective date together with the payment of a premature
                  termination fee in an amount equal to six (6) months rent at
                  the then current base rent rate.

            b)    After the expiration of nine (9) years the LESSEE may
                  prematurely terminate this Lease by following the procedures
                  set forth above except shall only pay an amount equal to three
                  (3) months rent at the then current base rent rate.

            c)    After the expiration of ten (10) years the LESSEE may
                  prematurely terminate this Lease by following the procedures
                  set forth above, except LESSEE shall not pay any termination
                  fee.

<PAGE>

7.   UTILITIES              The LESSEE shall pay, as they become due, all bills
                            for electricity and other utilities (whether they
     delete "air            are used for furnishing heat or other purposes) that
     conditioning" if not   are furnished to the leased premises and presently
     applicable             separately metered, and all bills for fuel furnished
                            to a separate tank servicing the leased premises
                            exclusively.

                            LESSOR shall have no obligation to provide utilities
                            or equipment other than the utilities and equipment
                            within the premises as of the commencement date of
                            this lease. In the event LESSEE requires additional
                            utilities or equipment, the installation and
                            maintenance thereof shall be the LESSEE`s sole
                            obligation, provided that such installation shall be
                            subject to the written consent of the LESSOR, which
                            shall not be unreasonably withheld.

8.   USE OF LEASED          The LESSEE shall use the leased premises only for
     PREMISES               the purpose of any business use consistent with the
     (fill in)              Cambridge Zoning Code and permitted within the
                            specific district.

9.   COMPLIANCE             The LESSEE acknowledges that no trade or occupation
     WITH LAWS              shall be conducted in the leased premises or use
                            made thereof which will be unlawful, improper, noisy
                            or offensive, or contrary to any law or any
                            municipal by-law or ordinance in force in the city
                            or town in which the premises are situated.

10.  FIRE INSURANCE         The LESSEE shall not permit any use of the leased
                            premises which will make voidable any insurance on
                            the property of which the leased premises are a
                            part, or on the contents of said property or which
                            shall be contrary to any law or regulation from time
                            to time established by the New England Fire
                            Insurance Rating Association, or any similar body
                            succeeding to its powers.

11.  MAINTENANCE            The LESSEE agrees to maintain the leased premises in
                            good condition, damage by fire and other casualty
     A. LESSEE'S            only excepted, and whenever necessary, to replace
        OBLIGATIONS         plate glass and other glass therein, acknowledging
                            that the leased premises are now in good order and
                            the glass whole*. The LESSEE shall not permit the
                            leased premises to be overloaded, damaged, stripped,
                            or defaced, nor suffer any waste/LESSEE shall
                            obtain written consent of LESSOR before erecting any
                            sign on the premises. other than normal wear and
                            tear.

     B. LESSOR'S            See Paragraph No. 24.    * provided LESSEE shall
        OBLIGATIONS                                    have the right to have
                                                       the premises inspected
                                                       prior to the commencement
                                                       date and any deficiencies
                                                       corrected by LESSOR.

12.  ALTERATIONS-           The LESSEE shall not make structural alterations or
     ADDITIONS              additions to the leased premises, but may make
                            non-structural alterations provided the LESSOR
See also                    consents thereto in writing, which consent shall not
Paragraph 25                be unreasonably withheld or delayed. All such
                            allowed alterations shall be at LESSEE's expense and
                            shall be in quality at least equal to the present
                            construction. LESSEE shall not permit any mechanics'
                            leins, or similar liens, to remain upon the leased
                            premises for labor and material furnished to LESSEE
                            or claimed to have been furnished to LESSEE in
                            connection with work of any character performed or
                            claimed to have been performed at the direction of
                            LESSEE and shall cause any such lien to be released
                            of record forthwith without cost to LESSOR. Any
                            alterations or improvments made by the LESSEE shall
                            become the property of the LESSOR at the termination
                            of occupancy as provided herein. except for those
                            which LESSEE elects to remove and repair any damage
                            caused by removal and except for LESSEE'S trade
                            fixtures and equipment.

13.  ASSIGNMENT-            The LESSEE shall not assign or sublet the whole or
     SUBLEASING             any part of the leased premises without LESSOR's
                            prior written consent Notwithstanding such consent,
                            LESSEE shall remain liable to LESSOR for the payment
                            of all rent and for the full performance of the
                            covenants and conditions of this lease. See also
                            paragraph 26 * which shall not be unreasonably
                            withheld.

<PAGE>

14.  SUBORDINATION          This lease shall be subject and subordinate to any
                            and all mortgages, deeds of trust and other
                            instruments in the nature of a mortgage, now or at
                            any time hereafter, a lien or liens on the property
                            of which the leased premises are a part and the
                            LESSEE shall, when requested, promptly execute and
                            deliver such written instruments as shall be
                            necessary to show the subordination of this lease to
                            said mortgages, deeds of trust or other such
                            instruments in the nature of a mortgage.

15.  LESSOR'S               The LESSOR or agents of the LESSOR may, at
     ACCESS                 reasonable times, enter to view the leased premises
                            and may remove placards and signs not approved and
                            affixed as herein provided, and make repairs and
                            alterations as LESSOR should elect to do and may
                            show the leased premises to others, and at any time
                            within three (3) months before the expiration of the
                            term, may affix to any suitable part of the leased
                            premises a notice for letting or selling the leased
                            premises or property of which the leased premises
                            are a part and keep the same so affixed without
                            hindrance or molestation.

16.  INDEMNIFICATION        The LESSEE shall save the LESSOR harmless from all
     AND LIABILITY          loss and damage occasioned by the use or escape of
     (fill in)              water or by the bursting of pipes, as well as from
                            any claim or damage resulting from neglect in not
                            removing snow and ice from the roof of the building
                            or from the sidewalks bordering upon the premises so
                            leased, or by any nuisance made or suffered on the
                            leased premises, unless such loss is caused by the
                            neglect of the LESSOR. The removal of snow and ice
                            from the sidewalks bordering upon the leased
                            premises shall be LESSOR'S responsibility.

17.  LESSEE'S LIABILITY     The LESSEE shall maintain with respect to the leased
     INSURANCE              premises and the property of which the leased
     (fill in)              premises are a part comprehensive public liability
                            insurance in the amount of with property damage
     See also               insurance in limits of in responsible companies
     paragraph 23.          qualified to do business in Massachusetts and in
                            good standing therein insuring the LESSOR as well as
                            LESSEE against injury to persons or damage to
                            property as provided. The LESSEE shall deposit with
                            the LESSOR certificates for such insurance at or
                            prior to the commencement of the term, and
                            thereafter within thirty (30) days prior to the
                            expiration of any such policies. All such insurance
                            certificates shall provide that such policies shall
                            not be cancelled without at least ten (10) days
                            prior written notice to each assured named therein.

18.  FIRE,                  Should a substantial portion of the leased premises,
     CASUALTY EMINENT       or of the property of which they are a part, be
     DOMAIN                 substantially damaged by fire or other casualty, or
                            be taken by eminent domain, the LESSOR may elect to
                            terminate this lease. When such fire, casualty, or
                            taking renders the leased premises substantially
                            unsuitable for their intended use, a just and
                            proportionate abatement of rent shall be made, and
                            the LESSEE may elect to terminate this lease if:

                              (a) The LESSOR fails to give written notice within
                                  thirty (30) days of intention to restore
                                  leased premises, or

                              (b) The LESSOR fails to restore the leased
                                  premises to a condition substantially suitable
                                  for their intended use within ninety (90) days
                                  of said fire, casualty or taking.

                            The LESSOR reserves, and the LESSEE grants to the
                            LESSOR, all rights which the LESSEE may have for
                            damages or injury to the leased premises for any
                            taking by eminent domain, except for damage to the
                            LESSEE's fixtures, property, or equipment.

19.  DEFAULT AND            In the event that:
     BANKRUPTCY
     (fill in)                (a) The LESSEE shall default in the payment of any
                                  installment of rent or other sum herein
                                  specfied and such default shall continue for
                                  ten (10) days after written notice thereof; or

                              (b) The LESSEE shall default in the observance or
                                  performance of any other of the LESSEE's
                                  covenants, agreements, or obligations
                                  hereunder and such default shall not be
                                  corrected within thirty (30) days after
                                  written notice thereof; or

                              (c) The LESSEE shall be declared bankrupt or
                                  insolvent according to law, or, if any
                                  assignment shall be made of LESSEE's property
                                  for the benefit of creditors,

                            then the LESSOR shall have the right thereafter,
                            while such default continues, to re-enter and take
                            complete possession of the leased premises, to
                            declare the term of this lease ended, and remove the
                            LESSEE's effects, without prejudice to any remedies
                            which might be otherwise used for arrears of rent or
                            other default. The LESSEE shall indemnify the LESSOR
                            against all loss of rent and other payments which
                            the LESSOR may incur by reason of such termination
                            during the residue of the term. If the LESSEE shall
                            default, after reasonable notice thereof, in the
                            observance or performance of any conditions or
                            covenants on LESSEE's part to be observed or
                            performed under or by virtue of any of the
                            provisions in any article of this lease, the LESSOR,
                            without being under any obligation to do so and
                            without thereby waiving such default, may remedy
                            such default for the account and at the expense of
                            the LESSEE. If the LESSOR makes any expenditures or
                            incurs any obligations for the payment of money in
                            connection therewith, including but not limited to,
                            reasonable attorney's fees in instituting,
                            prosecuting or defending any action or proceeding,
                            such sums paid or obligations insured, with interest
                            at the rate of 10 per cent per annum and costs,
                            shall be paid to the LESSOR by the LESSEE as
                            additional rent.

                            *Lessee at the address set forth above

20.  NOTICE                 Any notice from the LESSOR to the LESSEE relating to
     (fill in)              the leased premises or to the occupancy thereof
                            shall be deemed duly served, [ILLEGIBLE] or if
                            mailed to the leased premises, registered or
                            certified mail, return receipt requested, postage
                            prepaid, addressed to the LESSEE. Any notices from
                            the LESSEE to the LESSOR relating to the leased
                            premises or to the occupancy thereof, shall be
                            deemed duly served, if mailed to the LESSOR by
                            registered or certified mail, return receipt
                            requested, postage prepaid, addressed to the LESSOR
                            at such address as the LESSOR may from time to time
                            advise in writing. All rent notices shall be paid
                            and sent to the LESSOR at 300 Bent Street,
                            Cambridge, MA 02141

<PAGE>

21.  SURRENDER              The LESSEE shall at the expiration or other
                            termination of this lease remove all LESSEE's goods
                            and effects from the leased premises, (including,
                            without hereby limiting the generality of the
                            foregoing, all signs and lettering affixed or
                            painted by the LESSEE, either inside or outside the
                            leased premises). LESSEE shall deliver to the LESSOR
                            the leased premises and all keys, locks thereto, and
                            other fixtures connected therewith and all
                            alterations and additions made to or upon the leased
                            premises, in good condition, damage by fire or other
                            casualty only excepted. In the event of the LESSEE's
                            failure to remove any of LESSEE's property from the
                            premises, LESSOR is hereby authorized, without
                            liability to LESSEE for loss or damage thereto, and
                            at the sole risk of LESSEE, to remove and store any
                            of the property at LESSEE's expense, or to retain
                            same under LESSOR's control or to sell at public or
                            private sale, without notice any or all of the
                            property not so removed and to apply the net
                            proceeds of such sale to the payment of any sum due
                            hereunder, or to destroy such property.

22.  BROKERAGE              See Paragraph No. 27.
     (fill in or delete)                              **except Lessee's fixtures

23.  OTHER                  It is also understood and agreed that the Addendum
     PROVISIONS             annexed hereto shall be and hereby is incorporated
                            and made a part of the lease agreement.

IN WITNESS WHEREOF, the said parties hereunto set their hands and seals this____
day of April, 1990.

Biogen, Inc.                                        Fifth Street Realty Trust

By: /s/ David W. Dennen                             By: /s/ Steven D. Rosenberg
-----------------------------------                 ----------------------------
LESSEE Authorized Signatory                         LESSOR Steven D. Rosenberg,
       David W. Dennen, Ph. D.                             Trustee
       Vice President of Operations

<PAGE>

              Addendum to Lease By and Between Steven D. Rosenberg,
                as Trustee of Fifth Street Realty Trust (Lessor)
                       and Biogen, Inc. (lessee) covering
                the Property at 190 Fifth Street, Cambridge, MA

23.   The LESSEE shall provide and pay for fire insurance coverage of not less
than $1 Million with the Lessor named as an additional assured. A certificate
covering the fire insurance coverage shall be delivered to the Lessor with the
Lessor named thereon as an additional assured.

24.   The LESSOR agrees to maintain only the exterior structure and the roof
of the building of which the leased premises are a part in the same condition as
it is at the commencement of the term or as it may be put in during the term of
this lease by reasonable wear and tear or damage by fire or other casualty,
unless such maintenance is required because of the LESSEE or those for whose
conduct the LESSEE is legally responsible. The LESSOR also agrees to make all
repairs to the building structure and systems such as, but not limited to,
heating system, air conditioning system, electrical system, plumbing system,
elevator, fire protection system, and structural elements whenever an individual
repair exceeds $5,000.00 and is not due to the LESSEE'S negligence.

25.   The LESSOR shall not require the LESSEE to remove any agreed to
alterations at the termination of the lease.

26.   If the LESSEE elects to sublet all or any portion of the demised premises,
then it shall notify the LESSOR who shall have the option of entering into a new
Lease with the Sub-lessee covering said premises, thereby relieving LESSEE of
all of its obligation under this Lease for such premises.

27.   Brokerage - Both parties certify to the other that no broker was involved
in this Lease or is entitled to any commission as a result of this Lease and
each shall indemnify and save the other harmless from any such claims.

28.   The LESSOR agrees to finance, at the LESSEE'S option, up to $100,000.00 of
improvements and rehabilitation, of the demised premises, initiated before
December 31, 1990. Said amount shall be repaid together with interest on a
monthly basis at the rate of 14.25% per annum under a Ten (10) year

<PAGE>

amortization schedule of equal payments of interest and principal in arrears.
These payments will commence January 1, 1991 and conclude on December 1, 2000
and will be added to the base rent. The escalation of base rate shall not apply
to the funds loaned hereunder. In the event of premature termination the unpaid
principal shall be paid in a lump sum (forthwith) with no prepayment penalty.
LESSOR may prepay such amount at any time; the prepayment shall include unpaid
interest accrued to the date of prepayment, but shall not be subject to any
prepayment fee.

29.   The LESSOR shall by July 1, 1990:

      a)    secure and/or replace the broken windows;

      b)    repair the flooring on the 1st floor near the street dock as well as
            other floor penetrations;

      c)    clear out the parking area under the storage sheds;

      d)    remove the spray booth and all duct work used for duct control;

      e)    seal the subfloor vents against rodents and insects.

IN WITNESS WHEREOF, the said parties hereunto set their hands and seals this____
day of April, 1990.

BIOGEN, INC.                                         FIFTH STREET REALTY TRUST

By: /s/ David W. Dennen                              By: /s/ Steven D. Rosenberg
----------------------------                         ---------------------------
LESSEE Authorized Signatory                          LESSOR Steven D. Rosenberg,
David W. Dennen, Ph. D.                              Trustee
Vice President of Operations

<PAGE>

                                   EXHIBIT A

              [Location of Main Building in relation to cross streets,
                   corner of Bent Street and Fifth Street]

<PAGE>

                                   EXHIBIT B

                    [Floor Plan of First Floor of Main Building
                        100 Fifth Street, Cambridge, MA.]

<PAGE>

                                    EXHIBIT B

                    [Floor Plan of Second Floor of Main Building
                          100 Fifth Street, Cambridge, MA.]

<PAGE>

                                   EXHIBIT B

                   [Floor Plan of Third Floor of Main Building
                        100 Fifth Street, Cambridge, MA.]

<PAGE>

                              ESTOPPEL CERTIFICATE

First Trade Union Savings Bank F.S.B.
10 Drydock Avenue
Boston, MA 02205

Re:   Lease dated April, 1990 (the "Lease")
      by and between Steven D. Rosenberg,
      as Trustee of Fifth Street Realty Trust,
      a Massachusetts Declaration of Trust ("Landlord")
      and Biogen, Inc., a Massachusetts
      corporation ("Tenant")

Dear Sir/Madam:

      Reference is made to the above-described Lease in which the undersigned is
the Tenant. We understand that First Trade Union Savings Bank, F.S.B. ("the
Bank") is accepting an assignment of Landlord's rights under the Lease as
security for an obligation in the amount of Eight Hundred Fifty Thousand Dollars
($850,000.00) and we hereby, as a material inducement to you to loan said amount
to Landlord, represent that:

      1.    The Lease is for a term of Fourteen (14) years and Seven (7) months
commencing on June 1, 1990 or the date of the mortgage closing with the Bank,
whichever is later, and ending December 31, 2004; and the Lease covers all of
the real property known and numbered as 190 Fifth Street, Cambridge,
Massachusetts (the "Property"). A true and correct copy of the Lease is attached
hereto as Exhibit A and incorporated herein by reference thereto.

      2.    There are no modifications, amendments, supplements, arrangements,
side letters or understandings, oral or written, of any sort, modifying,
amending, altering, supplementing or changing the terms of the Lease.

      3.    The Lease is in full force and effect, and the Lease has been duly
executed and delivered by, and is a binding obligation of, the Tenant as set
forth therein.

      4.    There are no security deposits held by Landlord, and there are no
other payments on account previously made by Tenant to the Landlord.

      5.    The undersigned acknowledges a) that the Lease is a Triple Net Lease
with the base rent until December 31, 1991 in an amount of $164,000.00 per annum
or $13,666.66 per month payable in advance on a monthly basis, and b) that no
rent yet been paid under the Lease and no rent shall be paid in the future for a
period in excess of one (1) month in advance.

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      6.    TO THE BEST OF THE TENANT'S KNOWLEDGE, The improvements on the
Premises are free from defects in design, materials and workmanship; and the
improvements meet all governmental requirements, including, but not limited to,
zoning and environmental requirements.

      7.    Neither the Landlord nor the Tenant are in default under the Lease
and Landlord has peformed the obligations required to be performed by Landlord
under the terms thereof through the date hereof.

      8.    The Lease shall be subordinate to a Mortgage and Security Agreement
on the Premises by the Landlord to the Bank and an assignment of Landlord's
interest in the Lease given by Landlord to the Bank; and in the event of a
merger of Landlord and Tenant in any manner, the interest of Tenant and Landlord
shall not merge.

      9.    Landlord and Tenant agree not to modify, amend, terminate, assign or
otherwise change the Lease without the prior written consent of the Bank.

      10.   In the event of a default by Landlord under any of the terms or
provisions of the Lease, Tenant shall give adequate notice to the Bank and
sufficient time to cure such default.

Date: June 7, 1990

                                                    Very truly yours,

                                                    Biogen, Inc.

                                                    By: /s/ David W. Dennen
                                                    ----------------------------
                                                    David W. Dennen, Ph.D.
                                                    Vice President of Operations
                                                    Hereunto Duly Authorized

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