Document:

exv10w29

Exhibit 10.29

EXCLUSIVE LICENSE AND SPONSORED RESEARCH AGREEMENT

between

OMEROS CORPORATION and the UNIVERSITY OF LEICESTER

     This license agreement (the “Agreement”) is made effective the 10th day of June 2004 (the
“Effective Date”) between Omeros Corporation, a Washington corporation having a principal place of
business at 1420 Fifth Avenue, Suite 2600, Seattle WA 98101 USA (“Omeros”) and the University of
Leicester, having a principal place of business at University Road, Leicester LE1 7RH, United
Kingdom (“Leicester”).

     WHEREAS Leicester owns rights to certain technology related to mannan-binding lectin
associated serine protease-2 (“MASP-2”) and a MASP-2 related plasma protein of 19 kDa commonly
referred to as “MAp19”, which technology was developed in whole or in part by Wilhelm J. Schwaeble,
Ph.D., (“Dr. Schwaeble” or the “Principal Investigator”) and Cordula M. Stover, Ph.D. (“Dr.
Stover”), both employees of Leicester, and has obtained ownership of related technology developed
by Teizo Fujita (“Dr. Fujita”) of the Fukushima Medical University, School of Medicine
(“Fukushima”); and

     WHEREAS Omeros wishes to undertake an exclusive license in Leicester’s MASP-2 and MAp19
technology (including the related technology developed by Dr. Fujita), and to sponsor further
research to develop Leicester’s MASP-2 and MAp19 technology at Leicester under the direction of the
Principal Investigator; and

     WHEREAS Leicester wishes to grant Omeros an exclusive license in Leicester’s
 MASP-2 and MAp19 technology (including the related technology developed by Dr. Fujita) in
return for potential royalty payments and sublicense revenue sharing, and to accept payment for
such sponsored research;

     NOW THEREFORE, in consideration for the mutual covenants and obligations set forth herein as
well as other good and valuable consideration, the parties hereby agree as follows:

	1	 	Definitions
	 
	1.1	 	Reference to “Leicester” and “Omeros” in regards to any intellectual property right developed
by the respective party shall be construed to refer to the respective party as well as the
respective party’s employees, officers, directors, consultants and agents.
	 
	1.2	 	“Intellectual Property Rights” shall mean all inventions, ideas, discoveries, issued,
reissued or reexamined patents, pending and future patent applications, continuation,
continuation-in-part and divisional patent applications, utility models, inventor’s
certificates, trade secrets, know-how, copyrights and trademarks.
	 
	1.3	 	“Sponsored Research” shall mean all research activities carried out by Leicester and/or its
employees (as may be agreed by Leicester and Omeros) with the financial sponsorship, in whole
or in part, by Omeros in accordance with Section 2 herein below or as otherwise agreed.

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-1-

 

	1.4	 	“Leicester IP” shall mean all Intellectual Property Rights owned or held by Leicester,
including without limitation all such Intellectual Property Rights arising from the work of
Dr. Schwaeble, Dr. Stover, and/or other Leicester employees as well as that acquired under an
assignment agreement from Dr. Fujita, prior to the Effective Date of this Agreement, or
developed or obtained by Leicester after the Effective Date of this Agreement both (a)
independently of Omeros (as determined by inventorship under US law with respect to any
patents and patent applications) and (b) independently of the Sponsored Research, provided
however that in the event and to the extent that such independently developed Intellectual
Property Rights arise as the direct result of sponsorship by a not-for-profit enterprise in
accordance with Section 4.3 herein, such independently developed Intellectual Property Rights
shall be included within the scope of the license granted herein only if Leicester or
Leicester employee(s) obtain an assignment or release of such independently developed
Intellectual Property Rights from such not-for-profit enterprise, which assignment or release
Leicester shall exert all reasonable efforts to obtain or to cause its employees to obtain,
provided always that any of the Intellectual Property Rights described above in this section
1.4 are directly related to compositions, antibodies and/or methods for the inhibition of
MASP-2 and/or MAp19 and/or the diagnosis and/or treatment of MASP-2 or MAp19 mediated
disorders and/or deficiency syndromes, as well as methods, polynucleotides, polypeptides,
sequences and tools related to the development and production of MASP-2 or MAp19 antibodies
including without limitation murine, human, humanized and recombinant antibodies, murine lines
in which MASP-2 or MAp19 genes have been knocked-out or knocked-in, and all Intellectual
Property Rights in the subject matter disclosed or claimed in the draft patent application
entitled Genetically modified non-human mammals and cells filed in the British Patent
Office on 10 June 2004 and attached hereto as Exhibit A [†].
	 
	1.5	 	“Omeros IP” shall mean all Intellectual Property Rights owned or held by Omeros prior to the
Effective Date of this Agreement, or developed or obtained by Omeros after the Effective Date
of this Agreement independently of Leicester (as determined by inventorship under US law with
respect to any patents and patent applications), including without limitation all such
Intellectual Property Rights related to methods and pharmaceuticals or other agents to inhibit
pain, inflammation, cartilage loss, vasospasm, smooth muscle spasm, restenosis, or tumor cell
adhesion, and/or to accelerate recovery of joint motion and function, for use in surgical
procedures (including without limitation arthroscopic, cardiovascular, urologic and general
surgical procedures), other medical procedures, and/or for treatment of cartilaginous
disorders, and drug delivery methods and systems.
	 
	1.6	 	“Joint IP” shall mean (a) all Intellectual Property Rights in technology that is developed
jointly (as determined by inventorship with respect to any patents and patent applications) by
Omeros and Leicester (as may be agreed by Leicester and Omeros) during the Sponsored Research
Term (as that term is defined in Section 2.2 herein), and (b) all Intellectual Property Rights
arising from and as the direct result of the Sponsored Research. Should Dr. Schwaeble or
other Leicester employees enter into a consulting agreement with Omeros for general scientific
consulting such as in the field of

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-2-

 

	 	 	inflammation, then to the extent that such scientific consulting services may pertain to
MASP-2 and MAp19, the results of such scientific consulting services will be treated as part
of the Joint IP. However, the parties acknowledge herein that research by Dr. Schwaeble and
other Leicester employees on behalf of Omeros related to MASP-2 and MAp19 will be carried
out in major part through the Sponsored Research.
	 
	1.7	 	[†]
	 
	1.8	 	“Licensed Products” shall mean all antibodies, inhibitors and all other products that, were
it not for the license granted to Omeros under this Agreement, infringe, or the use,
manufacture, offer for sale or sale of which infringe any valid and subsisting claim(s) of any
issued patent or any patentable claim(s) of any pending patent application included within the
Leicester IP in the country or countries in which such products are offered for sale, sold,
manufactured or used, excluding all products that would be included within the Licensed
Products in accordance with the above definition only because they are products that infringe
any claim(s) within the [†].
	 
	1.9	 	“Licensed Research Products” shall mean any antibodies that are not Licensed Products and
which are produced or developed as the direct result of use of murine line(s) that, were it
not for the license granted to Omeros under this Agreement, infringe, or the use of which
infringe, any valid and subsisting claim(s) of any issued patent or any patentable claim(s) of
any pending patent application for such murine line(s) included within the Leicester IP in the
country or countries in which such lines are propagated or used.
	 
	1.10	 	“Net License Proceeds” shall mean the total of the gross monetary amounts invoiced and
collected by Omeros for Licensed Products and Licensed Research Products (or that portion of
the value of any combination product attributed to a Licensed Product or a Licensed Research
Product included therein) used, manufactured, directly sold or directly distributed by Omeros,
less (a) the sum of the following actual and customary deductions where applicable: cash,
trade, or quantity discounts; sales, use, tariff, import/export duties or other excise taxes,
and any other governmental taxes imposed on particular sales; transportation charges and
allowances; commissions to third party sales agents; and credits to customers because of
rejections or returns and (b) any accrued Omeros IP Legal Fees (as defined below) not
previously deducted. For purposes of this paragraph, the acquisition of Licensed Products and
Licensed Research Products from Omeros as part of an acquisition of all or a substantial part
of the assets of Omeros’ business to which this Agreement pertains shall not be considered a
manufacture, sale or distribution.
	 
	1.11	 	“Net Sublicense Proceeds” shall mean the total of all sublicense royalties or sublicense fees
received by Omeros from third parties to which Omeros grants a sublicense under the Leicester
IP for the manufacture, sale or distribution of Licensed Products or Licensed Research
Products, and which were not included in the Net License Proceeds, less any accrued Omeros IP
Legal Fees not previously deducted, provided however that the Net Sublicense Proceeds shall
not include any fees or payments from such third parties to Omeros to support research and
development efforts, to purchase equity in Omeros, or for any other purpose other than as compensation for sublicense rights.

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-3-

 

	1.12	 	“Omeros IP Legal Fees” shall mean the sum of all legal fees and costs incurred by Omeros to
(a) evaluate, apply for, prosecute and maintain any Intellectual Property Rights included
within the Leicester IP, including without limitation any such fees and costs paid by Omeros
as reimbursement to Leicester for such fees and costs incurred by Leicester, and (b) obtain or
assist Leicester in obtaining or attempting to obtain clear, defensible, lawful and
uncontested title to the Leicester IP, including without limitation all such fees and costs
incurred in [†].
	 
	1.13	 	“Third Party License Fees” shall mean all royalties or other fees paid by Omeros to third
parties for a license from such third parties under Intellectual Property Rights owned or held
by such third parties for the manufacture, use, offer for sale, sale or distribution of
Licensed Products or Licensed Research Products, but shall exclude that portion of any such
third party royalties or other fees paid by Omeros attributed to items sold in combination
with the Licensed Products or the Licensed Research products, which items are not Licensed
Products or Licensed Research products.
	 
	2	 	Sponsored Research
	 
	2.1	 	Leicester shall perform research to be conducted by or under the direction of the Principal
Investigator (as may be agreed between Leicester and Omeros), directed to advancing the
technology included in the Leicester IP or related technology concerning the characterization
and inhibition of MASP-2 or MAp19, supported by the financial sponsorship of Omeros, and
without the use of third party sponsorship that would provide any intellectual property rights
in the results of the Sponsored Research to such third party, in accordance with one or more
research plans (“Research Plans”) agreed to in advance in writing between Leicester and
Omeros. An initial Research Plan is attached hereto as Exhibit B. No Research Plan or any
amendment thereto shall be effective until executed by Leicester and Omeros, and upon mutual
execution shall be automatically incorporated into this Agreement. Each Research Plan shall
define scientific aims, objectives and activities, a budget and a timeline for performance of
Sponsored Research during the corresponding time period.
	 
	2.2	 	The Sponsored Research shall be completed over a term (the “Sponsored Research Term”) that
will initially run for a period of one (1) year from the appointment or designation of
appropriate and mutually acceptable staff at Leicester, and that is extendable annually upon
mutual written agreement for a total term of three (3) years from the Effective Date of this
Agreement or as may otherwise be mutually agreed in writing. If Omeros or Leicester does not
wish to extend the Sponsored Research Term for the second or the third year, such party shall
provide the other party notice of non-extension at least ninety (90) days prior to the end of
the preceding year. The Sponsored Research Term shall run independently of the License Term
(as defined herein below) of this Agreement. Termination of this Agreement shall result in
termination of the Sponsored Research Term, but termination of the Sponsored Research Term,
such as in accordance with Section 14.4 herein, shall not affect the overall status of this Agreement
or the License Term.

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-4-

 

	2.3	 	Leicester shall supply all necessary personnel, administrative management, facilities,
equipment and supplies to enable timely completion of the Sponsored Research. Reimbursement
for Leicester’s costs and expenses for the Sponsored Research shall be provided only to the
extent agreed to in writing in the applicable Research Plan. Each Research Plan will be
completed diligently by Leicester using best efforts in accordance with prevailing
professional standards and all applicable laws, regulations and Leicester’s official policies.
Should the Principal Investigator become unavailable to complete any Research Plan, Leicester
and Omeros may agree on a substitute investigator, and in the event that a mutually acceptable
substitute is not available, either party may terminate the Sponsored Research Term.
	 
	2.4	 	Within thirty (30) days of the end of each quarter of the Sponsored Research Term, Leicester
shall submit a status report in written and electronic form (“Status Report”) summarizing the
results of the research completed during that quarter, except that annually within thirty (30)
days of the end of each year of the Sponsored Research Term or at such other point in time as
may be mutually agreed in writing, Leicester shall submit a final status report in written and
electronic form (“Final Report”) detailing the results of the research completed during such
year of the Sponsored Research Term. Upon Omeros’ request, Leicester shall complete all
requested corrections and make reasonable revisions to each Status Report and/or Final Report
to place it into a form suitable to meet Omeros’ objectives, including potential use of any
Status Report and/or any Final Report as part of any regulatory submissions.
	 
	2.5	 	In full and complete consideration for the Sponsored Research completed by Leicester during
the Sponsored Research Term in accordance with the Research Plan(s), Omeros shall pay
Leicester [†] for the first year, and unless a change in the level of Sponsored
Research work is agreed to in writing in subsequent Research Plans, this amount shall be
increased by [†] per year plus, in the event of continued use of a Leicester
laboratory technician in performing Sponsored Research activities after the first year of the
Sponsored Research Term, any increase in fees due to British national standard pay scale
changes applicable on a pro rata basis to such Leicester laboratory technician’s Sponsored
Research activities, for each mutually agreed subsequent year of the Sponsored Research Term
throughout which Sponsored Research is carried out (i.e., a total of [†] if the
Sponsored Research Term is extended for a total three-year period and the level of Sponsored
Research work during each year remains constant), payable at the rate of [†] of the
annual amount per quarter within thirty (30) days of the end of each quarter within the
Sponsored Research Term, provided however that no payment shall be due for any quarter prior
to the receipt and acceptance by Omeros of a Status Report or any Final Report, as
appropriate, for the respective quarter or year.
	 
	2.6	 	Omeros and the Principal Investigator shall collaborate on any proposed scientific
publications of Sponsored Research data and results, including a discussion of authorship
and contents. Leicester shall furnish Omeros with copies
of any publication or written or oral disclosure that is
proposed by Leicester, including, without limitation,
disclosures in papers or abstracts or at research seminars,
lectures, professional meetings, or poster sessions, at
least sixty (60) days prior to the proposed date for
submission for publication

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-5-

 

or disclosure. During such 60-day period, Omeros shall have the right to review and
comment on such publication for accuracy and protection of
confidential information. Additionally, upon Omeros’
written request during the foregoing 60-day period, the
proposed submission for publication or disclosure shall be
delayed until Omeros has completed the filing of patent
applications directed to information contained in such
proposed publication or disclosure or based on Omeros’
reasonable determination that publication should be delayed
due to other business considerations, but in no event will
such delay exceed an additional ninety (90) days following
the initial 60-day period without Leicester’s written
consent, which consent shall not be unreasonably withheld.
Omeros shall have the right, in its sole discretion, to
use, disclose, disseminate and publish (with due
acknowledgement of authorship) all data and results arising
out of the Sponsored Research for any and all purposes,
including without limitation in and for submissions to any
regulatory agencies and in marketing any products
including, but not limited to, Licensed Products and
Licensed Research Products.

	3	 	Ownership of Intellectual Property
	 
	3.1	 	All Leicester IP shall remain owned or held by Leicester to the same extent as would be the
case were it not for this Agreement.
	 
	3.2	 	All Omeros IP shall remain owned or held by Omeros to the same extent as would be the case
were it not for this Agreement.
	 
	3.3	 	All Joint IP shall be jointly owned by Omeros and Leicester, i.e., Omeros and Leicester each
shall hold a 50% undivided joint ownership interest in all Joint IP.
	 
	4	 	Grant Of License
	 
	4.1	 	Leicester hereby grants to Omeros for the term of this Agreement a royalty-bearing,
world-wide exclusive license in the Leicester IP for the research, development, manufacture,
use, sale, offering for sale, distribution, exportation and importation of any and all
products and the practice of all methods within the Leicester IP, including without limitation
the exclusive right to develop, manufacture, use, sell, offer for sale, distribute, export and
import the Licensed Products and the Licensed Research Products and to use all murine lines
within the Leicester IP for all purposes including without limitation the research,
development and production of antibody products.
	 
	4.2	 	Leicester hereby grants to Omeros a fully-paid up, irrevocable, world-wide exclusive license
in and to Leicester’s joint ownership interest in the Joint IP, for the manufacture, use,
sale, offering for sale, distribution, exportation and importation of any and all products and
the practice of all methods encompassed by the Joint IP.
	 
	4.3	 	Subject to publication approval and timing procedures consistent with Section 2.6 herein,
Leicester shall retain the right to use the Leicester IP and the Joint IP for the purpose of
conducting non-commercial, academic research, including research sponsored by not-for-profit
entities, which shall not include the performance of research sponsored (directly or

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-6-

 

indirectly) by or on behalf of any for-profit entity that is in direct competition with Omeros
in a technology, product or research tool that is the subject of the Leicester IP or Joint IP.

	4.4	 	Omeros shall have the right to grant sublicenses in the Leicester IP and the Joint IP under
this Agreement subject, with respect to the Leicester IP, to Omeros’ obligations to share
sublicense revenues as set forth in Section 5.
	 
	4.5	 	As part of the licenses granted to Omeros under Sections 4.1 and 4.2, Leicester agrees to
transfer and provide and/or make available to Omeros upon request progeny from the licensed
murine lines, cell lines, biological materials and any other research materials encompassed by
or included within the Leicester IP and/or the Joint IP to which Leicester has appropriate
rights and access, all such materials being provided on the basis of Omeros reimbursing
Leicester for Leicester’s actual cost in providing such materials but for no additional
consideration.
	 
	4.6	 	Leicester also grants to Omeros a right of first refusal for an exclusive license in all of
Leicester’s Intellectual Property Rights, for which Omeros has not already been granted a
license hereunder, and for which Leicester has all necessary rights to offer such first
refusal, and Leicester shall exert reasonable efforts to obtain such necessary rights, in (1)
any commercially applicable technology that arises during the Term of this Agreement and is
directly related to MASP-2 and/or MAp19 as more fully defined in the Leicester IP and the
Joint IP, and (2) any technology that has been developed through the contribution of both
Omeros and Leicester after the Sponsored Research Term.
	 
	5	 	Royalties and Sublicense Revenue
	 
	5.1	 	Omeros shall pay Leicester on a quarterly basis a royalty for Licensed Products of
[†] of the that portion of the Net License Proceeds realized during each respective
quarter from Licensed Products (the “Licensed Product Royalty”), provided however that Omeros
shall be entitled to deduct from the Licensed Product Royalty any accrued Third Party License
Fees paid by Omeros on the Licensed Products not already deducted, but in no event shall Third
Party License Fees be permitted to be deducted to an extent that such Third Party License Fees
would reduce the Licensed Product Royalty by greater than [†] for any given quarter.
	 
	5.2	 	Omeros shall pay Leicester on a quarterly basis a royalty for Licensed Research Products (the
“Licensed Research Products Royalty”) of (a) [†] of that portion of the Net License
Proceeds realized from Licensed Research Products during each respective quarter during and
only during the first three (3)-year period following initial introduction of the relevant
product to a commercial market, and (b) [†] of that portion of the Net License
Proceeds realized from Licensed Research Products during each respective quarter after the
first three-year period until such time that any third party should introduce into a commercial
market a competing product that does not infringe the Leicester IP, after which third-party
introduction no further Licensed Research Products Royalty shall be payable for the relevant
product, provided however that Omeros shall be entitled to

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-7-

 

	 	 	deduct from the Licensed Research Products Royalty any accrued Third-Party License Fees paid by Omeros on Licensed Research
Products not already deducted, but in no event shall Third-Party License Fees be permitted
to be deducted to an extent that such Third Party License Fees would reduce the Licensed
Research Products Royalty by greater than [†] for any given quarter.
	 
	5.3	 	Omeros shall pay Leicester on a quarterly basis a share of that portion of the Net Sublicense
Proceeds collected by Omeros on Licensed Products and collected by Omeros (“Sublicensed
Product Revenue Share”) from sublicensed third parties during each respective quarter, such
Sublicensed Product Revenue Share being either (a) [†] for any sublicenses in
connection with the Licensed Products granted hereunder prior to the earlier of (i)
[†], or (ii) the second year anniversary of the Effective Date of this Agreement, or
(b) [†] for any sublicenses in connection with the Licensed Products granted
hereunder thereafter.
	 
	5.4	 	Omeros shall pay Leicester on a quarterly basis a “Sublicensed Research Product Revenue
Share” that is (a) an initial percentage share (“First Share Percentage”) of that portion of
the Net Sublicense Proceeds realized from Licensed Research Products and collected by Omeros
from sublicensed third parties during each respective quarter during and only during the first
three (3)-year period following initial introduction to a commercial market of the relevant
antibody product by the respective sublicensee, and (b) a subsequent percentage share (“Second
Share Percentage”) of that portion of the Net Sublicense Proceeds realized from Licensed
Research Products and collected by Omeros from sublicensed third parties during each
respective quarter after the initial three-year period. For any sublicenses in
connection with Licensed Research Products granted hereunder prior to the earlier of (i)
[†], or (ii) the second year anniversary of the Effective Date of this Agreement, the
First Share Percentage shall be [†] and the Second Share Percentage shall be
[†]. For any sublicenses in connection with Licensed Research Products granted
hereunder thereafter, the First Share Percentage shall be [†] and the Second Share
Percentage shall be [†].
	 
	5.5	 	Omeros shall promptly provide Leicester with a copy of all sublicenses granted by Omeros in
the Leicester IP and/or the Joint IP under this Agreement.
	 
	5.6	 	Following receipt from the University of the results of all Sponsored Research and the
completion of all other necessary and beneficial research activities by Omeros and/or by
others to support appropriate government regulatory submissions by Omeros, [†],
Omeros shall use reasonable efforts, based on reasonable commercial prudence, to diligently
develop and introduce to the market one or more Licensed Products and/or Licensed Research
Products. Ongoing performance of research and/or development efforts to generate or further
advance one or more Licensed Products and/or Licensed Research Products by Omeros, internally at Omeros and/or under contract with Leicester and/or a third
party, shall be deemed to be diligent efforts under this Section 5.6.
	 
	5.7	 	It is Omeros’ current intent to commercially develop and seek regulatory clearance to
clinically test and then market an inhibitor of MASP-2 and/or MAp19 activity following

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-8-

 

	 	 	Leicester’s identification of selective and high-affinity inhibitors of MASP-2 and MAp19
activity and demonstration by Leicester of the therapeutic benefit of such inhibitors in
animal models. Within three months of the identification by Omeros of a Licensed Product or
Licensed Research Product that is determined by Omeros to be a viable and optimal clinical
development candidate, Omeros will submit a development plan to Leicester that sets forth
Omeros’ planned activities and estimated timing for the development, regulatory approval and
market introduction of one or more Licensed Products and/or Licensed Research products.
Assuming anticipated and adequate progress is made in the Sponsored Research [†],
Omeros anticipates the identification of an initial potential candidate for a Licensed Product
or Licensed Research Product that is a potential clinical development candidate within two
years of the commencement of the Sponsored Research. The foregoing statements within this
Section 5.7 and such development plan are or will be provided as indications of current or
future intentions only, and shall have no binding effect on Omeros, nor shall it give rise to
any right or obligation to either party, and any modification, alteration or failure to meet
any of these intentions shall have no impact on this Agreement.
	 
	6	 	Payments
	 
	6.1	 	Quarterly royalty and sublicense revenue payments shall be made in British Pounds Sterling by
Omeros to Leicester within sixty (60) days of the end of the quarter. Payments shall be
computed based on a conversion from any other denomination to British Pounds Sterling for any
revenues received or costs and expenses incurred by Omeros during the relevant quarter or
other reporting period, as provided herein, using the prevailing exchange rate in effect at
the date and time that funds are transferred from Omeros’ account to Leicester’s account (in
the case of payment by wire transfer) or at the date and time of issuance of a check by Omeros
(in the case of payment by check). Each quarterly payment shall be accompanied by a report
specifying (a) the source of the royalties itemized by product and country, (b) any Omeros IP
Legal Fees or Third Party License Fees that were deducted from gross proceeds to determine Net
License Proceeds or Net Sublicense Proceeds as provided in Sections 1.10 or 1.11 of this
Agreement, and (c) the total of all discounts, returns, credits and commissions deducted from
gross proceeds to determine Net License Proceeds or Net Sublicense Proceeds as provided in
Sections 1.10 or 1.11 of this Agreement. Following the two-year anniversary of the Effective
Date of this Agreement, in the event that Omeros receives no such quarterly royalty and
sublicense revenue in any given quarter, it shall nevertheless submit a quarterly report to
that effect to Leicester within sixty (60) days of the end of the quarter.
	 
	6.2	 	Leicester reserves the right to employ a certified public accountant to review and reconcile
the directly relevant accounting records and procedures of Omeros as they relate to the determination of royalties or sublicense revenue fees under Section 5 herein during
reasonable business hours and no more than twice a year, and Omeros agrees to make available
at Omeros’ place of business all such directly relevant accounting records for that purpose
within 30 (thirty) days of written request by Leicester. The cost of such review shall be
borne by Leicester, unless it is found that Omeros under-paid a quarterly royalty or
sublicense revenue fees for any quarter by an amount of 10% (ten percent) or greater, in
which case the cost of such review shall be borne by Omeros.

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-9-

 

	6.3	 	In the event any royalty or sublicense revenue fee payments due under Section 5 herein are
not timely paid by Omeros, Omeros shall pay to Leicester interest charges on such late
payments at a rate of [†] per annum.
	 
	6.4	 	Not withstanding anything to the contrary herein, Omeros shall have no obligation to pay any
royalties or sublicense revenue fees under Section 5 for any product based on any patent claim
that has been declared invalid or unenforceable by a court or governmental body of competent
jurisdiction or based on any patent claim that is not enforceable in the jurisdiction(s) where
such products are manufactured, used, sold, offered for sale, imported or distributed.
	 
	7	 	License Progress
	 
	7.1	 	Omeros shall on an annual basis, commencing on the one-year anniversary of the Effective Date
of this Agreement and annually thereafter, deliver to Leicester within thirty (30) days after
the end of the respective year a written progress report detailing the status of Omeros’
efforts to fund, patent, develop and commercialize Licensed Products and Licensed Research
Products.
	 
	8	 	Patent Prosecution
	 
	8.1	 	Omeros shall have the sole right at its discretion to apply for, prosecute and maintain
patents for inventions included within the Leicester IP and the Joint IP (“Patent Filings”) in
the name of the legally appropriate inventors and/or parties to this agreement and/or jointly
with third parties as may be legally appropriate, provided however that (a) Omeros shall bear
all cost and expense for all such Patent Filings, subject to the right to deduct Omeros IP
Legal Fees as set forth herein, (b) Omeros shall keep Leicester timely informed of the
progress of all Patent Filings and timely provide Leicester copies of all official
documentation related to such Patent Filings, (c) at Omeros’ discretion and until such time
that Omeros provides a written request for transfer of responsibility, Leicester shall
continue at Omeros’ cost with the prosecution of any patent applications for the Leicester IP
it may have filed prior to the Effective Date of this Agreement, subject to consultation with
and direction from Omeros prior to taking any substantive action, but in any event Omeros
shall assume responsibility for prosecuting the patent application attached as Exhibit A
hereto within two months following the later of the filing of such patent application by
Leicester or the Effective Date of this Agreement, and (d) Omeros shall exert commercially
reasonable efforts to diligently pursue all Patent Filings to issuance or final determination
of unpatentability, provided however that if Omeros determines at its sole discretion to not make Patent Filings for any commercially
significant inventions within the Leicester IP or the Joint IP in any countries of
commercial significance, or abandons any Patent Filing prior to issuance or final
determination of unpatentability, Omeros shall give Leicester advance written notice of such
determination, Leicester shall have the right thereafter to elect upon written notice to
Omeros to pursue such Omeros abandoned Patent Filings at Leicester’s sole expense,

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-10-

 

	 	 	and such Omeros abandoned Patent Filings shall be excluded from the scope of the licenses granted
under this Agreement.
	 
	8.2	 	Omeros shall reimburse Leicester for Leicester’s reasonable documented legal fees and costs
paid by Leicester for any patent applications prepared and/or filed or prosecuted by Leicester
for inventions within the Leicester IP prior to the effective date of this Agreement or in
accordance with Section 8.1 above. Payment for such reimbursed expenses shall be made within
thirty (30) days of Omeros’ having received a receipt-documented invoice from Leicester,
provided however that Leicester represents that all such legal fees and costs incurred by
Leicester prior to the effective date of this Agreement shall not exceed [†].
	 
	8.3	 	Leicester shall promptly provide written disclosure to Omeros of any inventions,
improvements, or applications included within the Leicester IP or Joint IP conceived,
developed, made or arising before or during the term of this Agreement. Leicester will
provide all reasonable assistance, including review of documents and the execution of all
documents and causing Leicester’s employees to review and execute all documents, necessary to
make, prosecute, maintain and enforce the Patent Filings, all for no additional consideration
but with reimbursement by Omeros of Leicester’s reasonable expenses for such assistance.
	 
	8.4	 	Leicester shall promptly provide written disclosure to Omeros of any and all potentially
material prior art known prior to the Effective Date of this Agreement or that becomes known
during the License Term of this Agreement to any Leicester employee that is associated with
this Agreement, the Sponsored Research, the Leicester IP or the Joint IP.

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-11-

 

	9	 	Representations, Warranties and Other Obligations of Omeros
	 
	9.1	 	Omeros represents and warrants that it has the requisite corporate power and authority and
the legal right to enter into this Agreement and to perform its obligations hereunder.
	 
	9.2	 	Omeros has and will maintain reasonably adequate insurance coverage for employment practices
and general liability for all its activities under this Agreement. Prior to Omeros’ marketing
of any Licensed Product, Licensed Research Products, or product encompassed by the Joint IP,
or making any such products available for use in any human patients, Omeros will obtain and
maintain reasonably adequate product liability insurance.
	 
	10	 	Representations, Warranties and Other Obligations of Leicester
	 
	10.1	 	Leicester has disclosed to Omeros the existence of the
NatImmune Patent Applications and information as to the
development of the Leicester IP, and Leicester warrants that it has made reasonable efforts to
ascertain the details of such development and that it reasonably
believes the same to be true. Leicester and Omeros [†] Leicester is the lawful joint owner of certain invention(s)
disclosed in the NatImmune Patent Applications and is lawfully entitled to establish joint
ownership title in and to the NatImmune Patent Applications.  Leicester acknowledges
that the ability of Leicester to establish clear, defensible, uncontested and lawful title to
Leicester’s joint ownership rights in the NatImmune Patent Applications [†] in the
NatImmune Patent Applications is of material importance to Omeros, and any potential
failure to obtain such title or rights to Omeros’ satisfaction will be grounds for Omeros, at
Omeros’ sole discretion, to terminate this Agreement and its respective payment
obligations under Section 5 herein, or to seek modification of this Agreement, any such
modification (but not such termination) to be mutually agreed in accordance with Section 16.1.

	 
	10.2	 	
Leicester and Omeros agree to cooperate and assist each other in establishing Leicester’s
clear, defensible, uncontested and lawful title to Leicester's joint or sole ownership rights
[†] in the NatImmune Patent Applications and, except as provided expressly herein,
neither party shall [†].  After the Effective Date of this Agreement and after Omeros has
provided Leicester written confirmation that Omeros has made sufficient [†] (and not
prior to receipt of such written confirmation), Leicester shall [†].  At Omeros’ discretion,
upon written notice to Leicester, Omeros shall have the right,  at Omeros’ expense and
following [†] provided that Omeros will keep Leicester timely informed of [†] in the
NatImmune Patent Applications, [†] consideration to any concerns or comments made by
Leicester to Omeros, and except as expressly authorized herein will not undertake on
behalf of Leicester [†] and shall not, except to the extent expressly agreed in writing prior
to doing so, make [†].  Omeros agrees that it will [†] and not take any action or make any
[†].  Leicester acknowledges that Omeros’ [†] to achieve the objectives set forth herein
are likely to be [†] and making such [†] shall not, of themselves, be considered [†] nor
shall the taking of any [†].  Neither party shall
[†] without the other party’s written
consent, which consent shall not be unreasonably withheld if such action is reasonably
necessary to achieve the objectives of this Agreement; provided that Omeros shall at all
times keep Leicester timely informed of all [†] and Leicester shall be entitled to [†] in
connection with any such [†] and Omeros shall give Leicester reasonable advance notice
to the extent practical prior to [†].  Not withstanding anything to the contrary above
within this Section 10.2 or elsewhere in this Agreement, Leicester acknowledges that
Omeros is under no affirmative duty or obligation to [†] and that Omeros shall have the
absolute right and shall be free to, concurrent with or subsequent to delivery of Omeros’
written notice to Leicester of termination of this Agreement under Section 14.2 herein,
take whatever actions are needed and enter into any agreements necessary to [†] provided
that Omeros shall give Leicester reasonable advance notice to the
extent practical prior to [†].

	 
	10.3	 	Leicester and Omeros acknowledge that the [†].
[†] this Agreement shall continue in force unless
terminated in accordance with the provisions of Section 14.2 or 14.3
herein, [†] or portions thereof shall be deemed to be
excluded from the Leicester IP.
	 
	10.4	 	Leicester represents and warrants, subject to the disclosure referred to in Section 10.1,
that it is the owner of all right, title and interest in any and all inventions included
within the Leicester IP and the Joint IP made or to be made wholly or jointly by Leicester
employees, including without limitation those made by Dr. Schwaeble and Dr. Stover, and shall
cause Dr. Schwaeble and Dr. Stover to each execute this Agreement to confirm their agreement
to be bound to the same extent as Leicester with respect to all relevant provisions of this
Agreement.
	 
	10.5	 	Leicester represents and warrants that it is the owner of all right, title and interest in
any and all inventions that were made wholly or jointly by Dr. Fujita that are included within
the Leicester IP, has obtained an assignment from Dr. Fujita together with a release of all
such rights from Fukushima, has provided to Omeros a true copy of such assignment and release,
is under no restriction or obligation with respect to Dr. Fujita or Fukishima that is
inconsistent in any way with Leicester’s obligations under this Agreement, and that Omeros
shall have no obligation to compensate Dr. Fujita or Fukushima as the result of Omeros’
exercise of its rights and fulfillment of its obligations under this Agreement.
	 
	10.6	 	Subject to [†] as discussed in Section 10.1 above, Leicester represents and warrants
to Omeros that as far as it is aware, after having used reasonable efforts to ascertain
relevant facts and having formed a reasonable belief as to their truth, it has the lawful
right to grant the licenses conveyed under this Agreement, and that the Leicester IP and the
Joint IP are unencumbered by any third party obligation, commitment, restriction or license.
[†].

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-12-

 

	10.7	 	[†], Leicester warrants that it is not aware of any third party rights that
would be infringed as a result of Omeros’ fulfilling the terms of this Agreement.
	 
	10.8	 	Leicester has and will maintain reasonably adequate insurance coverage for employment
practices and general liability for all its activities under this Agreement.
	 
	10.9	 	THE WARRANTIES SET FORTH EXPRESSLY IN THIS AGREEMENT ARE THE SOLE
WARRANTIES MADE BY EITHER PARTY TO THE OTHER AND THERE ARE NO OTHER WARRANTIES,
REPRESENTATIONS OR GUARANTEES OF ANY KIND WHATSOEVER, EITHER EXPRESS OR IMPLIED, REGARDING THE
LICENSED PRODUCTS, THE LICENSED RESEARCH PRODUCTS, OR OTHER PRODUCTS, INCLUDING
WITHOUT LIMITATION ANY EXPRESS OR IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A
PARTICULAR PURPOSE.
	 
	11	 	Confidentiality
	 
	11.1	 	Leicester and Omeros hereby affirm and incorporate by reference the terms of the Mutual
Nondisclosure Agreement between the parties dated September 23, 2003 concerning the subject
matter of this Agreement, a copy of which is attached hereto as Exhibit C, except to the
extent that the terms of such nondisclosure agreement may conflict with the terms of this
Agreement, in which case the terms of this Agreement shall prevail. The parties further agree
that the mutual obligations of nondisclosure and non-use set forth in such Mutual
Nondisclosure Agreement shall subsist for a period of five (5) years after the termination of
this Agreement.
	 
	11.2	 	The terms of this Agreement shall be maintained in strict confidence by both Leicester and
Omeros, and may not be disclosed by either party without the consent of the other party,
except as may be required under a court order or decree or as required to comply with any
governmental law, rule or regulation, and Omeros may disclose the terms of this Agreement to
Omeros’ current and potential employees, directors, consultants, shareholders, investors and
corporate partners.
	 
	12	 	Indemnification
	 
	12.1	 	Each party (the “Indemnifying Party”) shall indemnify, hold harmless and defend the other
party and its employees, officers, directors, consultants and agents (the “Indemnified Party”)
against any and all claims, suits, losses, liabilities, damages, costs, fees, and expenses
(“Claims”) resulting from or arising directly out of the Indemnifying Party’s breach of any
representation, warranty or obligation under this Agreement, or the Indemnifying Party’s
exercise of the rights and obligations under this license or any sublicense, except that such
obligation to indemnify, hold harmless and defend shall not extend to any Claims to the extent
such Claims result from or arise directly from the negligence or misconduct of the Indemnified
Party. This indemnification does not include any indemnity in relation to product performance
or product liability, and furthermore does not include any incidental, consequential or
special damages.

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-13-

 

	13	 	Enforcement of Patent Rights
	 
	13.1	 	If either party learns of the infringement of any patent or other intellectual property right
included in the Leicester IP or the Joint IP, that party shall promptly notify the other party
of such infringement and will provide the other party with all evidence of infringement in the
notifying party’s possession. Both parties shall use their best efforts in cooperation with
each other to terminate third party infringement without litigation.
	 
	13.2	 	Omeros shall have the sole right at its discretion to enforce the Leicester IP and the Joint
IP against third party infringers, including the initiation of any civil action in Omeros’
name, at Omeros’ sole cost, in which event any award, judgment, settlement or damages
collected shall belong solely to Omeros without duty to account to Leicester. In the event
that it is necessary for Omeros to join Leicester as a party to any such civil action,
Leicester shall join such action for no additional compensation but at Omeros’ sole expense,
and any award, judgment, settlement or damages collected shall belong solely to Omeros without
duty to account to Leicester.
	 
	13.3	 	If Omeros unreasonably declines to initiate enforcement of the Leicester IP and the Joint IP
against any third party infringer within ninety (90) days of a written demand from Leicester
to do so, then Leicester shall have the sole right at its discretion to enforce the Leicester
IP and the Joint IP against such third party infringer, including the initiation of any civil
action in Leicester’s name, at Leicester’s sole cost, in which event any award, judgment,
settlement or damages collected shall belong solely to Leicester without duty to account to
Omeros.
	 
	14	 	Term and Termination
	 
	14.1	 	Unless terminated earlier as set forth in Section 14.2 or 14.3 herein below, this Agreement
shall subsist so long as there is any pending patent application within the Leicester IP or
the Joint IP, any patent application in the process of being prepared for filing as agreed to
by Omeros and Leicester or any valid and subsisting claim included within any patent, utility
model or inventor’s certificate within the Leicester IP or the Joint IP (the “License Term”).
	 
	14.2	 	Omeros may terminate this Agreement by providing ninety (90)-days advance written notice of
termination under this Section 14.2 to Leicester, with or
without cause, at any time [†].
	 
	14.3	 	Either party may terminate this Agreement at any time in the event that the other party (a) breaches any material obligation of this Agreement by first submitting written notice of
breach to the breaching party, which breach is not substantially cured within ninety (90)
days of the receipt of such notice, followed by written notice of termination then being
sent to the breaching party, or (b) declares or is adjudged by a court of competent
jurisdiction to be insolvent, bankrupt or in receivership, and such insolvency, bankruptcy
or receivership materially limits such party’s ability to perform its obligation under this
Agreement, excluding reorganizations entered into by such party with the consent of the
other party, which consent shall not be unreasonably withheld.

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-14-

 

	14.4	 	Omeros may at any time terminate its sponsorship of the Sponsored Research by providing
ninety (90)-days advance written notice of termination under this Section 14.4 to Leicester,
with or without cause, at any time, in which event Sections 2.1 — 2.3 herein shall cease to be
effective, and Sections 2.4 and 2.5 shall cease to be effective after all reports are provided
and accepted and all payments are made for Sponsored Research performed in accordance with the
applicable Research Plan prior to such notice, but the remainder of this Agreement shall
continue in full force and effect for the License Term, including all rights and obligations
of both parties hereunder. In the event of Omeros’ termination of its sponsorship of the
Sponsored Research under this Section 14.4, Omeros shall pay to Leicester any and all
non-cancelable sums reasonably incurred or committed to by Leicester prior to receipt of the
notice of termination.
	 
	14.5	 	The provisions of Sections 2.6 (Publication), 3 (Ownership of Intellectual Property), 4.2 -
4.6 (License as applicable to Joint IP and right of first refusal), 8 (Patent Prosecution as
applicable to Joint IP), 9 and 10 (Representations and Warranties and Other Obligations), 11
(Confidentiality), 12 (Indemnification), 13 (Enforcement as applicable to Joint IP), 15 (Use
of Names) and 16 (Miscellaneous) above shall survive expiration or termination of this
Agreement for the period set forth therein or, if no period is set forth therein, then
indefinitely.
	 
	15	 	Use of Names
	 
	15.1	 	Nothing contained in this Agreement confers any right to either party to use in advertising,
publicity, or other promotional activities any name, trade name, trademark, or other
designation of the other party hereto, and neither party shall make such use without the prior
written consent of the other party, provided however Omeros may through written, oral or
electronic communication disclose the existence of this Agreement and the names of Leicester,
Dr. Schwaeble, Dr. Stover, Dr. Fujita and other of Leicester’s employees and consultants to
Omeros’ current and potential employees, directors, consultants, shareholders, investors and
corporate partners, and as required to comply with any governmental law, rule or regulation.
	 
	16	 	Miscellaneous
	 
	16.1	 	This Agreement including all appendices and exhibits attached thereto or incorporated by
reference therein constitutes the entire understanding of the parties hereto regarding the
subject matter of this Agreement, and no other representation, agreement, promise or
undertaking altering, modifying, taking from or adding to the terms of this Agreement shall
have any effect unless the same is reduced to writing and duly executed by the parties hereto.
In the event of any conflict between the main body of this Agreement and any attachments
thereto or documents incorporated by reference therein, the provisions of the main body of
this Agreement shall control.
	 
	16.2	 	Either party’s failure to enforce any provision of this Agreement will not be considered a
waiver of future enforcement of that or any other provision.

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-15-

 

	16.3	 	The laws of the state of Delaware, United States, without regard to its conflict-of-laws
provisions, shall govern this Agreement, its interpretation and its enforcement, and any
disputes arising out of or related to this Agreement.
	 
	16.4	 	The parties agree that, except as provided herein below, any claim or controversy arising out
of or relating to this Agreement or breach thereof shall be settled by arbitration in the
state of Delaware, United States, in accordance with the commercial rules of the American
Arbitration Association by a panel of three arbitrators, one selected by each party and the
third selected by the other two arbitrators. In any such arbitration proceeding, judgment
upon the award rendered by the arbitrator shall be final and binding upon the parties and may
be entered by either party in any court or forum of competent jurisdiction as provided herein
below. Notwithstanding the foregoing, both parties agree that any claims or controversies
concerning the validity or enforceability of any intellectual property, or the actual or
threatened disclosure or misuse of confidential information, may alternately be resolved by a
civil action in any court of competent jurisdiction as provided herein below, and both parties
further agree that each shall retain the right to seek injunctive relief in any court of
competent jurisdiction as provided herein below to prevent a breach, threatened breach or
continuing breach of this Agreement which would cause irreparable injury (e.g., breaches of
confidentiality or the like).
	 
	16.5	 	Any civil action prosecuted or instituted by either party as permitted herein above with
respect to any matters arising out of or related to this Agreement shall be brought in either
the United States District Court located in the state of Delaware, United States (if federal
subject matter jurisdiction therein lies) or the Superior Court for the state of Delaware,
United States (if there is no subject matter jurisdiction in federal court), and each party
hereby consents to the jurisdiction and venue of such courts for such purposes.
	 
	16.6	 	In the event that it is necessary for either party of this Agreement to take legal action to
enforce any of the terms, conditions or rights contained herein, or to defend any such action,
then the prevailing party in such action shall be entitled to recover from the other party all
reasonable attorneys fees, costs and expenses related to such legal action.
	 
	16.7	 	In the event that any portion of this Agreement is held invalid or unenforceable by a court
of law, that provision will be construed and reformed to permit enforcement of the provision
to the maximum extent permissible consistent with the parties’ original intent, and if such
construction is not possible, such provision shall be struck from this Agreement, and the
remainder of the Agreement shall remain in full force and effect as if such provision had
never been part of this Agreement.
	 
	16.8	 	For the purposes of this Agreement, the parties hereto are independent contractors, and
nothing in this Agreement shall be construed to place them in the relationship of partners,
principal and agent, employer/employee or joint venturers. Except as provided expressly
herein, each party agrees that it shall have no authority to bind or obligate the other party,
nor shall any party hold itself out as having such authority.

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-16-

 

	16.9	 	Neither party will be liable for failure or delay in performing any obligation under this
Agreement, or will be considered in breach of this Agreement, if such failure or delay is
due to a natural disaster or any cause reasonably beyond such party’s control, provided that
such party resumes performance as soon as possible following the end of the event that
caused such delay or failure of performance.
	 
	16.10	 	Neither party may assign this Agreement, or any obligation or right under this Agreement, in
whole or in part, without the other party’s prior written consent, which consent will not be
unreasonably withheld. This Section shall not be construed in any way to limit Omeros’ rights
to grant, at Omeros’ sole discretion, sublicenses hereunder. Leicester consents to Omeros’
assignment of this Agreement in whole or in part in connection with the merger, consolidation
or transfer of all or substantially all of that portion of Omeros’ assets to which this
Agreement relates. Subject to these restrictions, this Agreement will be binding upon and
will inure to the benefit of the parties’ permitted successors and assignees.
	 
	16.11	 	Any notice required or permitted to be given hereunder by either party shall be in writing
and shall be (a) delivered personally, (b) sent by registered mail, return receipt requested,
postage prepaid, (c) sent by an internationally recognized courier service guaranteeing
next-day delivery, charges prepaid, or (d) delivered by facsimile (with the original promptly
sent by any of the foregoing manners) to the addresses or facsimile numbers of the other party
set forth below, or at such other addresses as may from time to time be furnished by similar
notice by either party. The effective date of any notice hereunder shall be the date of
receipt by the receiving party.

	 	 	 	 	 
	 

	 	If to Omeros:
	 	If to Leicester:
	 
	 	 	 	 
	 

	 	Omeros Corporation
	 	University of Leicester
	 

	 	1420 Fifth Avenue, Suite 2600
	 	University Road
	 

	 	Seattle, WA 98101
	 	Leicester, LE1 7RH
	 

	 	U.S.A.
	 	United Kingdom

	 	 	 	 	 	 	 
	 

	 	Attention:
	 	Gregory A. Demopulos, M.D.,
	 	Attention: Research and
	 

	 	 	 	Chairman & CEO
	 	Business Development Office
	 
	 	 	 	 	 	 
	 

	 	And copy to:
	 	Marcia S. Kelbon,	 	 
	 

	 	 	 	Patent & General Counsel	 	 

	 	 	 	 	 
	 

	 	Fax: (206) 264.7856
	 	Fax: +44 (0) 116.252.2028
	 

	 	Phone: (206) 623.4688
	 	Phone: +44 (0) 116.252.2347

	16.12	 	This Agreement may be executed in one or more counterparts, each of which will be considered
an original, and all of which will constitute the same instrument.

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-17-

 

     IN WITNESS WHEREOF, Omeros and Leicester have each acknowledged and accepted this Agreement by
causing it to have been signed by their respective duly authorized officials.

	 	 	 	 	 	 	 	 	 
	OMEROS CORPORATION	 	UNIVERSITY OF LEICESTER	 	 
	 
	 	 	 	 	 	 	 	 
	By:

	 	/s/ Gregory A. Demopulos
 

	 	By:
	 	/s/ Clare O’Neill
 

	 	 
	 
	 	 	 	 	 	 	 	 
	Name:

	 	Gregory A. Demopulos, M.D.
	 	Name:
	 	Clare O’Neill
 

	 	 
	 
	 	 	 	 	 	 	 	 
	Title:

	 	Chairman & CEO
	 	Title:
	 	Business Development Manager
 

	 	 
	 
	 	 	 	 	 	 	 	 
	Date:

	 	7/6/04 
 

	 	Date:
	 	10th June 2004
 

	 	 
	 
	 	 	 	 	 	 	 	 
	Fax:

	 	206.264.7856 
	 	Fax:
	 	0044 116 252 2028
 

	 	 

The above Exclusive License and Sponsored Research Agreement is acceptable to the
undersigned investigators, who agree to abide by the terms set forth therein.

	 	 	 	 	 	 	 	 	 
	WILHELM J. SCHWAEBLE, PH.D.	 	CORDULA M. STOVER, PH.D.
	 
	Signed:

	 	/s/ Wilhelm J. Schwaeble
 

	 	Signed:
	 	/s/ Cordula M. Stover
 
 
	Title:

	 	Professor of Immunology
 

	 	Title:
	 	Lecturer in Immunology
 
 
	Date:

	 	10/06/04
 

	 	Date:
	 	10 June 04
 
 
	Fax:

	 	0044-116-252-5030
 

	 	Fax:
	 	0044-116-252-5030
 
 

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-18-

 

EXHIBIT A

To the Exclusive License and Sponsored Research Agreement

Between Omeros Corporation and the University of Leicester

PATENT APPLICATION

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-19-

 

EXHIBIT B

To the Exclusive License and Sponsored Research Agreement

Between Omeros Corporation and the University of Leicester

RESEARCH PLAN

1st-Year Research Program Outline — Omeros and University of Leicester

     The following are the research aims of the Sponsored Research program for the first year. All
activities to meet the aims are to be carried out by Leicester (“Dr. Schwaeble’s lab”) except for
those aims noted for performance by Omeros, other investigators or contractors. Aims indicated as
to be performed by Omeros or third parties are provided herein for reference purposes only and
shall not be interpreted as any obligation on the part of Omeros. Specific aims and corresponding
timeline may be modified as mutually agreed in writing by Dr. Wilhelm Schwaeble and Omeros.

     Aims as set forth will extend into a second year of the Sponsored Research Program.

     Specific Aims:

     [†] [Redaction continues for three pages]

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-20-

 

EXHIBIT C

To the Exclusive License and Sponsored Research Agreement

Between Omeros Corporation and the University of Leicester

MUTUAL CONFIDENTIALITY AGREEMENT

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-21-exv10w31

Exhibit 10.31

EXCLUSIVE LICENSE AND SPONSORED RESEARCH AGREEMENT

between

OMEROS CORPORATION and MEDICAL RESEARCH COUNCIL

     This license agreement (the “Agreement”) is made effective the 31st day of October 2005 (the
“Effective Date”) between Omeros Corporation, a Washington corporation having a principal place of
business at 1420 Fifth Avenue, Suite 2600, Seattle WA 98101 USA (“Omeros”) and Medical Research
Council, a United Kingdom governmental institution having a place of business at 20 Park Crescent,
London, United Kingdom, W1B 1AL (“MRC”).

     WHEREAS MRC owns rights to certain technology related to mannan-binding lectin associated
serine protease-2 (“MASP-2”), which technology was developed in part by Anthony C. Willis (“Mr.
Willis”) working in an MRC laboratory under the direction of Professor Kenneth B. M. Reid (“Dr.
Reid”), both employees of MRC;

     WHEREAS Omeros holds an exclusive, worldwide license to rights owned by the University of
Leicester (“Leicester”) related to the MASP-2 technology due to the development in part of the
MASP-2 technology by Leicester’s employees;

     WHEREAS Omeros wishes to undertake an exclusive license to MRC’s rights in the MASP-2
technology, and to sponsor further research by MRC to develop the MASP-2 technology at MRC, under
the direction of Dr. Reid, working in collaboration with Omeros and Leicester; and

     WHEREAS MRC wishes to grant Omeros an exclusive license in MRC’s rights to the MASP-2
technology in return for potential royalty payments and sublicense revenue sharing, and to accept
payment for such sponsored research;

     NOW THEREFORE, in consideration for the mutual covenants and obligations set forth herein as
well as other good and valuable consideration, the parties hereby agree as follows:

	1	 	Definitions
	 
	1.1	 	Reference to “MRC” and “Omeros” in regards to any intellectual property right developed by
the respective party shall be construed to refer to the respective party as well as the
respective party’s employees, officers, directors, consultants and agents.
	 
	1.2	 	“Intellectual Property Rights” shall mean all inventions, ideas, discoveries, issued,
reissued or reexamined patents, pending and future patent applications, continuation,
continuation-in-part and divisional patent applications, utility models, inventor’s
certificates, trade secrets, know-how, copyrights and trademarks.
	 
	1.3	 	“Sponsored Research” shall mean all research activities carried out by MRC and/or its
employees (as may be agreed by MRC and Omeros) with the financial sponsorship, in whole or in
part, by Omeros in accordance with Section 2 herein below or as otherwise agreed.

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-1-

 

	1.4	 	“MRC IP” shall mean all Intellectual Property Rights owned or held by MRC, including without
limitation all such Intellectual Property Rights arising from the work of Mr. Willis, Dr. Reid
and/or other MRC employees, prior to the Effective Date of this Agreement, or developed or
obtained by MRC after the Effective Date of this Agreement both (a) independently of Omeros
(as determined by inventorship under US law with respect to any patents and patent
applications) and (b) independently of the Sponsored Research, provided always that any of the
Intellectual Property Rights described above in this section 1.4 are directly related to
compositions, antibodies and/or methods for the inhibition of MASP-2 and/or the diagnosis
and/or treatment of MASP-2 mediated disorders and/or deficiency syndromes, as well as methods,
polynucleotides, polypeptides, sequences and tools related to the development and production
of MASP-2 antibodies, including without limitation murine, human, humanized and recombinant
antibodies, MASP-2 inhibitors, [†].
	 
	1.5	 	“Omeros IP” shall mean all Intellectual Property Rights owned or held by Omeros prior to the
Effective Date of this Agreement, or developed or obtained by Omeros after the Effective Date
of this Agreement independently of MRC (as determined by inventorship under US law with
respect to any patents and patent applications), including without limitation all such
Intellectual Property Rights (a) related to MASP-2 obtained by Omeros under license from
Leicester (including without limitation all MASP-2 and MAp19 rights conveyed under the
Omeros-Leicester Agreement of 10 June 2004) or developed by Omeros independently of MRC by
Omeros and (b) related to methods and pharmaceuticals or other agents to inhibit pain,
inflammation, cartilage loss, vasospasm, smooth muscle spasm, restenosis, or tumor cell
adhesion, and/or to accelerate recovery of joint motion and function, for use in surgical
procedures (including without limitation arthroscopic, cardiovascular, urologic and general
surgical procedures), other medical procedures, and/or for treatment of cartilaginous
disorders, and drug delivery methods and systems.
	 
	1.6	 	“Joint IP” shall mean (a) all Intellectual Property Rights in technology that is developed
jointly (as determined by inventorship with respect to any patents and patent applications) by
Omeros and MRC (as may be agreed by MRC and Omeros) during the Sponsored Research Term (as
that term is defined in Section 2.2 herein), and (b) all Intellectual Property Rights arising
from and as the direct result of the Sponsored Research. Joint IP may or may not also be
jointly developed with Leicester or other third party, which will not change the nature of the
Intellectual Property Rights as Joint IP so long as the first sentence of this Section
applies. Should any MRC employee enter into a consulting agreement with Omeros for general
scientific consulting such as in the field of inflammation, then to the extent that such
scientific consulting services may pertain to MASP-2, the results of such scientific
consulting services will be treated as part of the Joint IP. However, the parties acknowledge
herein that research by MRC employees on behalf of Omeros related to MASP-2 will be carried
out in major part through the Sponsored Research.

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-2-

 

	1.7	 	[†]
	 
	1.8	 	“Licensed Products” shall mean all antibodies, inhibitors and all other products that, were
it not for the license granted to Omeros under this Agreement, infringe, or the use,
manufacture, offer for sale or sale of which infringe any valid and subsisting claim(s) of any
issued patent or any patentable claim(s) of any pending patent application included within the
MRC IP in the country or countries in which such products are offered for sale, sold,
manufactured or used, excluding all products that would be included within the Licensed
Products in accordance with the above definition only because they are products that [†].
	 
	1.9	 	“Net License Proceeds” shall mean the total of the gross monetary amounts invoiced and
collected by Omeros for Licensed Products (or that portion of the value of any combination
product attributed to a Licensed Product included therein) used, manufactured, directly sold
or directly distributed by Omeros, less (a) the sum of the following actual and customary
deductions where applicable: cash, trade, or quantity discounts; sales, use, tariff,
import/export duties or other excise taxes, and any other governmental taxes imposed on
particular sales; transportation charges and allowances; commissions to third party sales
agents; and credits to customers because of rejections or returns and (b) any accrued Omeros
IP Legal Fees (as defined below) not previously deducted. For purposes of this paragraph, the
acquisition of Licensed Products from Omeros as part of an acquisition of all or a substantial
part of the assets of Omeros’ business to which this Agreement pertains shall not be
considered a manufacture, sale or distribution.
	 
	1.10	 	“Net Sublicense Proceeds” shall mean the total of all sublicense royalties or sublicense fees
received by Omeros from third parties to which Omeros grants a sublicense under the MRC IP for
the manufacture, sale or distribution of Licensed Products, and which were not included in the
Net License Proceeds, less any accrued Omeros IP Legal Fees not previously deducted, provided
however that the Net Sublicense Proceeds shall not include any fees or payments from such
third parties to Omeros to support research and development efforts, to purchase equity in
Omeros, or for any other purpose other than as compensation for sublicense rights.
	 
	1.11	 	“Omeros IP Legal Fees” shall mean the sum of all legal fees and costs incurred by Omeros to
(a) evaluate, apply for, prosecute and maintain any Intellectual Property Rights included
within the MRC IP, including without limitation any such fees and costs paid by Omeros as
reimbursement to MRC for such fees and costs incurred by MRC, and (b) obtain or assist MRC in
obtaining or attempting to obtain clear, defensible, lawful and uncontested title to the MRC
IP, including without limitation all such fees and costs incurred in [†].
	 
	1.12	 	“Third Party License Fees” shall mean all royalties or other fees paid by Omeros to third
parties for a license from such third parties under Intellectual Property Rights owned or held
by such third parties for the manufacture, use, offer for sale, sale or distribution of
Licensed Products, but shall exclude that portion of any such third party royalties

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-3-

 

(including without limitation royalties payable to Leicester) or other fees paid by Omeros
attributed to items sold in combination with the Licensed Products, which items are not
Licensed Products.

	2	 	Sponsored Research
	 
	2.1	 	MRC shall perform research to be conducted by or under the direction of Dr. Reid and another
MRC senior research investigator (the “MRC Co-investigator”) working under the direction of
Dr. Reid as may be agreed between MRC and Omeros (Dr. Reid and the MRC Co-investigator
collectively “MRC Investigators”), directed to advancing the technology included in the MRC IP
or related technology concerning the characterization and inhibition of MASP-2, supported by
the financial sponsorship of Omeros, and without the use of third party sponsorship that would
provide any intellectual property rights in the results of the Sponsored Research to such
third party, in accordance with one or more research plans (“Research Plans”) agreed to in
advance in writing between MRC and Omeros. An initial Research Plan is attached hereto as
Exhibit A. The Research Plans may involve collaborative research efforts by Omeros, MRC
and/or Leicester as may be agreed between MRC and Omeros. No Research Plan or any amendment
thereto shall be effective until executed by MRC and Omeros, and upon mutual execution shall
be automatically incorporated into this Agreement. Each Research Plan shall define scientific
aims, objectives and activities, a budget and a timeline for performance of Sponsored Research
during the corresponding time period.
	 
	2.2	 	The Sponsored Research shall be completed over a term (the “Sponsored Research Term”) of
thirty four months (34 months) commencing 1 November 2005 or as may otherwise be mutually
agreed in writing. If Omeros or MRC wishes to terminate the Sponsored Research Term early,
such party shall provide the other party notice of non-extension at least ninety (90) days
prior to the end of any given year of the Sponsored Research term, i.e., by 3 August of such
year. In the event of a breach of this Agreement by MRC during the Sponsored Research Term,
Omeros may terminate the Sponsored Research Term as provided in accordance with Section 14.4
below at its sole discretion, without penalty. If Omeros should terminate the Sponsored
Research Term as provided in accordance with Section 14.4 below for any other reason before
completion of the full Sponsored Research Term, or upon completion of the full Sponsored
Research Term, Omeros will reimburse MRC for any legally required severance payable to the MRC
Co-investigator due solely to the termination or conclusion of the Sponsored Research, not to
exceed [†], provided, however that MRC will utilize its best efforts to minimize or avoid the
need for any such payment, including without limitation efforts to find other support for the
MRC Co-investigator, and provided further that MRC shall provide Omeros with documentation of
the legal requirement for and amount of any such severance. The Sponsored Research Term shall
run independently of the License Term (as defined herein below) of this Agreement.
Termination of this Agreement shall result in termination of the Sponsored Research Term, but
termination of the Sponsored Research Term, such as in accordance with this Section 2.2 or
Section 14.4 herein, shall not affect the overall status of this Agreement or the License
Term.

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-4-

 

	2.3	 	MRC shall supply all necessary personnel, administrative management, facilities, equipment
and supplies to enable timely completion of the Sponsored Research, including both of the MRC
Investigators, for the duration of the Sponsored Research Term. Reimbursement for MRC’s costs
and expenses for the Sponsored Research shall be provided only to the extent agreed to in
writing in the applicable Research Plan. Each Research Plan will be completed diligently by
MRC using best efforts in accordance with prevailing professional standards and all applicable
laws, regulations and MRC’s official policies. Should the MRC Investigators become
unavailable to complete any Research Plan, MRC and Omeros may agree on a substitute
investigator, and in the event that a mutually acceptable substitute is not available, either
party may terminate the Sponsored Research Term.
	 
	2.4	 	Within thirty (30) days of the end of each quarter of the Sponsored Research Term, MRC shall
submit a status report in written and electronic form (“Status Report”) summarizing the
results of the research completed during that quarter, except that annually within thirty (30)
days of the end of each year of the Sponsored Research Term or at such other point in time as
may be mutually agreed in writing, MRC shall submit a final status report in written and
electronic form (“Final Report”) detailing the results of the research completed during such
year of the Sponsored Research Term. Upon Omeros’ request, MRC shall complete all requested
corrections and make reasonable revisions to each Status Report and/or Final Report to place
it into a form suitable to meet Omeros’ objectives, including potential use of any Status
Report and/or any Final Report as part of any regulatory submissions.
	 
	2.5	 	In full and complete consideration for the Sponsored Research completed by MRC during the
Sponsored Research Term in accordance with the Research Plan(s), Omeros shall pay MRC a total
of [†] over the Sponsored Research Term in accordance with the annual schedule set forth in
Exhibit A, unless the Sponsored Research Terms is terminated earlier in accordance with the
provisions of this Section 2, in which case no further scheduled payments shall be payable, or
unless a change in the level of Sponsored Research work is agreed to in writing in subsequent
Research Plans, and subject to the following potential adjustment based on the British
national pay scale. The salary portion of the compensation amount payable during each year
includes a projected increase for changes in the British national standard pay scale, and
shall be adjusted up or down annually to reflect actual changes in the British national
standard pay scale. Compensation for each year of the Sponsored Research Term shall be
payable at the rate of twenty five percent (25%) of the annual amount per quarter, with a
first quarterly payment due and payable upon the start of the year, second and third quarterly
payments due and payable four and eight months, respectively, from the start of the year, and
a fourth quarterly payment due and payable upon the later of the end of the year or acceptance
of a Final Report for such year; provided, however, that no payment shall be due for any
quarter prior to the receipt and acceptance by Omeros of a Status Report or any Final Report,
as appropriate, for the respective quarter or year. All undisputed payments that have become
due and payable shall be paid within thirty (30) days of receipt of an invoice from MRC.

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-5-

 

	2.6	 	Omeros and the MRC Investigators shall collaborate on any proposed scientific publications of
Sponsored Research data and results, including a discussion of authorship and contents. MRC
shall furnish Omeros with copies of any publication or written or oral disclosure that is
proposed by MRC, including, without limitation, disclosures in papers or abstracts or at
research seminars, lectures, professional meetings, or poster sessions, at least sixty (60)
days prior to the proposed date for submission for publication or disclosure. During such
60-day period, Omeros shall have the right to review and comment on such publication for
accuracy and protection of confidential information. Additionally, upon Omeros’ written
request during the foregoing 60-day period, the proposed submission for publication or
disclosure shall be delayed until Omeros has completed the filing of patent applications
directed to information contained in such proposed publication or disclosure or based on
Omeros’ reasonable determination that publication should be delayed due to other business
considerations, but in no event will such delay exceed an additional ninety (90) days
following the initial 60-day period without MRC’s written consent, which consent shall not be
unreasonably withheld. Omeros shall have the right, in its sole discretion, to use, disclose,
disseminate and publish (with due acknowledgement of authorship) all data and results arising
out of the Sponsored Research for any and all purposes, including without limitation in and
for submissions to any regulatory agencies and in marketing any products including, but not
limited to, Licensed Products.
	 
	3	 	Ownership of Intellectual Property
	 
	3.1	 	All MRC IP shall remain owned or held by MRC to the same extent as would be the case were it
not for this Agreement.
	 
	3.2	 	All Omeros IP shall remain owned or held by Omeros to the same extent as would be the case
were it not for this Agreement.
	 
	3.3	 	All Joint IP shall be jointly owned by Omeros and MRC, i.e., Omeros and MRC each shall hold a
50% undivided joint ownership interest in all Joint IP, provided however that Omeros and MRC
recognize that third party collaborators such as Leicester may also have an ownership interest
in intellectual property included in the Joint IP, which third party ownership interest shall
not be impacted or determined by this Agreement.
	 
	4	 	Grant Of License
	 
	4.1	 	MRC hereby grants to Omeros for the term of this Agreement a royalty-bearing,
world-wide exclusive license in the MRC IP for the research, development, manufacture, use,
sale, offering for sale, distribution, exportation and importation of any and all products and
the practice of all methods within the MRC IP, including without limitation the exclusive
right to develop, manufacture, use, sell, offer for sale, distribute, export and import the
Licensed Products for all purposes including without limitation the research, development and
production of antibody or other MASP-2 inhibitor products.
	 
	4.2	 	MRC hereby grants to Omeros a fully paid-up, irrevocable, world-wide exclusive license
in and to MRC’s joint ownership interest in the Joint IP, for the manufacture, use, sale,

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-6-

 

offering for sale, distribution, exportation and importation of any and all products and the
practice of all methods encompassed by the Joint IP.

	4.3	 	Subject to publication approval and timing procedures consistent with Section 2.6
herein, MRC shall retain the right to use the MRC IP and the Joint IP for the purpose of
conducting non-commercial, academic research, including research sponsored by not-for-profit
entities, which shall not include the performance of research sponsored (directly or
indirectly) by or on behalf of any for-profit entity that is in direct competition with Omeros
in a technology, product or research tool that is the subject of the MRC IP or Joint IP.
	 
	4.4	 	Omeros shall have the right to grant sublicenses in the MRC IP and the Joint IP under
this Agreement subject, with respect to the MRC IP, to Omeros’ obligations to share sublicense
revenues as set forth in Section 5.
	 
	4.5	 	As part of the licenses granted to Omeros under Sections 4.1 and 4.2, MRC agrees to
transfer and provide and/or make available to Omeros upon request biological materials and any
other research materials and know-how encompassed by or included within the MRC IP and/or the
Joint IP to which MRC has appropriate rights and access, all such materials being provided on
the basis of Omeros reimbursing MRC for MRC’s actual cost in providing such materials but for
no additional consideration.
	 
	4.6	 	MRC also grants to Omeros a right of first refusal for an exclusive license in all of MRC’s
Intellectual Property Rights, for which Omeros has not already been granted a license
hereunder, and for which MRC has all necessary rights to offer such first refusal, and MRC
shall exert reasonable efforts to obtain such necessary rights, in (1) any commercially
applicable technology that arises during the Term of this Agreement and is directly related to
MASP-2 as more fully defined in the MRC IP and the Joint IP, and (2) any technology that has
been developed through the contribution of both Omeros and MRC after the Sponsored Research
Term.
	 
	5	 	Royalties and Sublicense Revenue
	 
	5.1	 	Omeros shall pay MRC on a quarterly basis a royalty for Licensed Products of [†] of that
portion of the Net License Proceeds realized during each respective quarter from Licensed
Products (the “Licensed Product Royalty”). Not withstanding the above, if the total royalties
owed by Omeros to all parties for Licensed Products, including without limitation the Licensed
Product Royalty payable to MRC, royalties payable to Leicester, [†] and any “stacking fee(s)”
or other royalties payable to third parties to develop, manufacture or commercialize the
Licensed Products (all together the “Total Royalty Percentage”), exceeds [†] of the Net
Licensed Proceeds for any quarter, then [†] of the difference between the Total Royalty
Percentage and [†] shall be deducted from the Licensed Product Royalty payable to MRC for such
quarter, provided, however that the Licensed Product Royalty for such quarter may not be
reduced by such deductions to less than [†].
	 
	5.2	 	Omeros shall pay MRC on a quarterly basis a share of that portion of the Net Sublicense

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-7-

 

Proceeds collected by Omeros on Licensed Products and collected by Omeros (“Sublicensed
Product Revenue Share”) from sublicensed third parties during each respective quarter, such
Sublicensed Product Revenue Share being either (a) [†] for any sublicenses in connection with
the Licensed Products granted hereunder prior to the earlier of (i) the establishment of MRC’s
clear, defensible, lawful and uncontested title in, or other mutually acceptable rights
relative to, [†] or (ii) the second year anniversary of the Effective Date of this Agreement,
or (b) [†] for any sublicenses in connection with the Licensed Products granted hereunder
thereafter.

	5.3	 	Omeros shall promptly provide MRC with a copy of all sublicenses granted by Omeros in the MRC
IP and/or the Joint IP under this Agreement.
	 
	5.4	 	Following receipt from the University of the results of all Sponsored Research and the
completion of all other necessary and beneficial research activities by Omeros and/or by
others to support appropriate government regulatory submissions by Omeros, [†] Omeros shall
use reasonable efforts, based on reasonable commercial prudence, to diligently develop and
introduce to the market one or more Licensed Products. Ongoing performance of research and/or
development efforts to generate or further advance one or more Licensed Products by Omeros,
internally at Omeros and/or under contract with MRC and/or a third party, shall be deemed to
be diligent efforts under this Section 5.4.
	 
	5.5	 	It is Omeros’ current intent to commercially develop and seek regulatory clearance to
clinically test and then market an inhibitor of MASP-2 activity following identification of
selective and high-affinity inhibitors of MASP-2 activity and demonstration of the therapeutic
benefit of such inhibitors in animal models, such identification and demonstration to be
completed collaboratively by MRC, Leicester and/or Omeros. Within three months of the
identification by Omeros of a Licensed Product that is determined by Omeros to be a viable and
optimal clinical development candidate, Omeros will submit a development plan to MRC that sets
forth Omeros’ planned activities and estimated timing for the development, regulatory approval
and market introduction of one or more Licensed Products. Assuming anticipated and adequate
progress is made in the Sponsored Research [†], Omeros anticipates the identification of an
initial potential candidate for a Licensed Product or Licensed Research Product that is a
potential clinical development candidate within two years of the commencement of the Sponsored
Research. The foregoing statements within this Section 5.5 and such development plan are or
will be provided as indications of current or future intentions only, and shall have no
binding effect on Omeros, nor shall it give rise to any right or obligation to either party,
and any modification, alteration or failure to meet any of these intentions shall have no
impact on this Agreement.
	 
	6	 	Payments
	 
	6.1	 	Quarterly royalty and sublicense revenue payments shall be made in British Pounds Sterling by
Omeros to MRC within sixty (60) days of the end of the quarter. Payments shall be computed
based on a conversion from any other denomination to British Pounds
Sterling for any revenues received or costs and expenses incurred by Omeros during the

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-8-

 

relevant quarter or other reporting period, as provided herein, using the prevailing
exchange rate in effect at the date and time that funds are transferred from Omeros’ account
to MRC’s account (in the case of payment by wire transfer) or at the date and time of
issuance of a check by Omeros (in the case of payment by check). Each quarterly payment
shall be accompanied by a report specifying (a) the source of the royalties itemized by
product and country, (b) any Omeros IP Legal Fees or Third Party License Fees that were
deducted from gross proceeds to determine Net License Proceeds or Net Sublicense Proceeds as
provided in Sections 1.9 or 1.10 of this Agreement, and (c) the total of all discounts,
returns, credits and commissions deducted from gross proceeds to determine Net License
Proceeds or Net Sublicense Proceeds as provided in Sections 1.9 or 1.10 of this Agreement.
Following the two-year anniversary of the Effective Date of this Agreement, in the event
that Omeros receives no such quarterly royalty and sublicense revenue in any given quarter,
it shall nevertheless submit a quarterly report to that effect to MRC within sixty (60) days
of the end of the quarter.

	6.2	 	MRC reserves the right to employ a certified public accountant to review and reconcile the
directly relevant accounting records and procedures of Omeros as they relate to the
determination of royalties or sublicense revenue fees under Section 5 herein during reasonable
business hours and no more than twice a year, and Omeros agrees to make available at Omeros’
place of business all such directly relevant accounting records for that purpose within 30
(thirty) days of written request by MRC. The cost of such review shall be borne by MRC,
unless it is found that Omeros under-paid a quarterly royalty or sublicense revenue fees for
any quarter by an amount of 10% (ten percent) or greater, in which case the cost of such
review shall be borne by Omeros.
	 
	6.3	 	In the event any royalty or sublicense revenue fee payments due under Section 5 herein are
not timely paid by Omeros, Omeros shall pay to MRC interest charges on such late payments at a
rate of [†] per annum.
	 
	6.4	 	Not withstanding anything to the contrary herein, Omeros shall have no obligation to pay any
royalties or sublicense revenue fees under Section 5 for any product based on any patent claim
that has been declared invalid or unenforceable by a court or governmental body of competent
jurisdiction or based on any patent claim that is not enforceable in the jurisdiction(s) where
such products are manufactured, used, sold, offered for sale, imported or distributed.
	 
	7	 	License Progress
	 
	7.1	 	Omeros shall on an annual basis, commencing on the one-year anniversary of the Effective Date
of this Agreement and annually thereafter, deliver to MRC within thirty (30) days after the
end of the respective year a written progress report detailing the status of Omeros’ efforts
to fund, patent, develop and commercialize Licensed Products.
	 
	8	 	Patent Prosecution
	 
	8.1	 	Omeros shall have the sole right at its discretion to apply for, prosecute and maintain
patents for inventions included within the MRC IP and the Joint IP (“Patent Filings”) in

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-9-

 

the name of the legally appropriate inventors and/or parties to this agreement and/or jointly with
third parties as may be legally appropriate, provided however that (a) Omeros shall bear all
cost and expense for all such Patent Filings, subject to the right to deduct Omeros IP Legal
Fees as set forth herein, (b) Omeros shall keep MRC timely informed of the progress of all
Patent Filings and timely provide MRC copies of all official documentation related to such
Patent Filings, and (c) Omeros shall exert commercially reasonable efforts to diligently
pursue all Patent Filings to issuance or final determination of unpatentability, provided
however that if Omeros determines at its sole discretion to not make Patent Filings for any
commercially significant inventions within the MRC IP or the Joint IP in any countries of
commercial significance, or abandons any Patent Filing prior to issuance or final
determination of unpatentability, Omeros shall give MRC advance written notice of such
determination, MRC shall have the right thereafter to elect upon written notice to Omeros to
pursue such Omeros abandoned Patent Filings at MRC’s sole expense (together with Leicester if
applicable), and such Omeros abandoned Patent Filings shall be excluded from the scope of the
licenses granted under this Agreement.

	8.2	 	MRC shall promptly provide written disclosure to Omeros of any inventions, improvements, or
applications included within the MRC IP or Joint IP conceived, developed, made or arising
before or during the term of this Agreement. MRC will provide all reasonable assistance,
including review of documents and the execution of all documents and causing MRC’s employees
to review and execute all documents, necessary to make, prosecute, maintain and enforce the
Patent Filings, all for no additional consideration but with reimbursement by Omeros of MRC’s
reasonable expenses for such assistance.
	 
	8.3	 	MRC shall promptly provide written disclosure to Omeros of any and all potentially material
prior art known prior to the Effective Date of this Agreement or that becomes known during the
License Term of this Agreement to any MRC employee that is associated with this Agreement, the
Sponsored Research, the MRC IP or the Joint IP.
	 
	9	 	Representations, Warranties and Other Obligations of Omeros
	 
	9.1	 	Omeros represents and warrants that it has the requisite corporate power and authority and
the legal right to enter into this Agreement and to perform its obligations hereunder.
	 
	9.2	 	Omeros has and will maintain reasonably adequate insurance coverage for employment practices
and general liability for all its activities under this Agreement. Prior to Omeros’ marketing
of any Licensed Product, or product encompassed by the Joint IP, or making any such products
available for use in any human patients, Omeros will obtain and maintain reasonably adequate
product liability insurance.
	 
	10	 	Representations, Warranties and Other Obligations of MRC
	 
	10.1	 	MRC has disclosed to Omeros the existence of the NatImmune
Patent Applications and information as to the development of
the MRC IP, and MRC warrants that it has made reasonable efforts to ascertain the details of
such development and that it reasonably believes the same to be true. MRC and Omeros [†] MRC is the lawful joint owner of certain invention(s) disclosed in
the NatImmune Patent Applications and is lawfully entitled to establish joint ownership
title in and to the NatImmune Patent Applications.  MRC acknowledges that the ability of
MRC to establish clear, defensible, uncontested and lawful title to MRC’s joint
ownership rights in the NatImmune Patent Applications [†] in the NatImmune Patent
Applications is of material importance to Omeros, and any potential failure to obtain such
title or rights to Omeros’ satisfaction will be grounds for Omeros, at Omeros’ sole
discretion, to terminate this Agreement and its respective payment obligations under
Section 5 herein, or to seek modification of this Agreement, any such modification (but
not such termination) to be mutually agreed in accordance with Section 16.1.

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-10-

 

	10.2	 	MRC and Omeros agree to cooperate and assist each other in establishing MRC’s clear,
defensible, uncontested and lawful title to MRC's joint or sole ownership rights [†] in the
NatImmune Patent Applications and, except as provided expressly herein, neither party
shall [†].  After the Effective Date of this Agreement and following the establishment of a
[†], Omeros shall [†], at Omeros’ discretion and expense and following [†], provided that
Omeros will keep MRC timely informed of [†] in the NatImmune Patent Applications,
[†] consideration to any concerns or comments made by MRC to Omeros, and except as
expressly authorized herein will not undertake on behalf of MRC [†], and shall not,
except to the extent expressly agreed in writing prior to doing so, make [†].  Omeros
agrees that it will [†], and not take any action or make any [†].  MRC acknowledges that
Omeros’ [†] to achieve the objectives set forth herein are likely to be [†], and making
such [†] shall not, of themselves, be considered [†], nor shall the taking of any [†].
Neither party shall [†] without the other party’s written consent, which consent shall not
be unreasonably withheld if such action is reasonably necessary to achieve the objectives
of this Agreement; provided that Omeros shall at all times keep MRC timely informed of
all [†], and MRC shall be entitled to [†] in connection with any such [†], and Omeros
shall give MRC reasonable advance notice to the extent practical prior to [†].  Not
withstanding anything to the contrary above within this Section 10.2 or elsewhere in this
Agreement, MRC acknowledges that Omeros is under no affirmative duty or obligation
to [†], and that Omeros shall have the absolute right and shall be free to, concurrent with
or subsequent to delivery of Omeros’ written notice to MRC of termination of this
Agreement under Section 14.2 herein, take whatever actions are needed and enter into
any agreements necessary to [†]; provided that Omeros shall give MRC reasonable
advance notice to the extent practical prior to [†].

	 
	10.3	 	MRC and Omeros acknowledge that the [†].
[†], this Agreement shall continue in force unless
terminated in accordance with the provisions of Section 14.2 or 14.3
herein, [†] or portions thereof shall be deemed to be
excluded from the MRC IP.
	 
	10.4	 	MRC represents and warrants, subject to the disclosure referred to in Section 10.1 with
respect [†] and to any rights owned by Leicester, that MRC is the owner of all other right,
title and interest in any and all inventions included within the MRC IP and the Joint IP made
or to be made wholly or jointly by MRC employees, including without limitation those made by
Mr. Willis and Dr. Reid, and shall cause Mr. Willis and Dr. Reid to each execute this
Agreement to confirm their agreement to be bound to the same extent as MRC with respect to all
relevant provisions of this Agreement.
	 
	10.5	 	Subject to [†] as discussed in Section 10.1 above and to any rights owned by Leicester, MRC
represents and warrants to Omeros that as far as it is aware, after having used reasonable
efforts to ascertain relevant facts and having formed a reasonable belief as to their truth,
it has the lawful right to grant the licenses conveyed under this Agreement, and that the MRC
IP and the Joint IP are unencumbered by any third party obligation, commitment, restriction or
license. [†]
	 
	10.6	 	[†] and any rights owned by Leicester, MRC warrants that it is not aware of any third party
rights that would be infringed as a result of Omeros’ fulfilling the terms of this Agreement.
	 
	10.7	 	MRC has and will maintain reasonably adequate insurance coverage for employment practices and
general liability for all its activities under this Agreement.
	 
	10.8	 	THE WARRANTIES SET FORTH EXPRESSLY IN THIS AGREEMENT ARE THE SOLE WARRANTIES
MADE BY EITHER PARTY TO THE OTHER AND THERE ARE NO OTHER WARRANTIES, REPRESENTATIONS OR
GUARANTEES OF ANY KIND WHATSOEVER, EITHER EXPRESS OR IMPLIED, REGARDING THE LICENSED PRODUCTS,
OR OTHER PRODUCTS, INCLUDING WITHOUT LIMITATION ANY EXPRESS OR IMPLIED WARRANTIES OF
MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE.
	 
	11	 	Confidentiality
	 
	11.1	 	MRC and Omeros hereby affirm and incorporate by reference the terms of the Mutual
Nondisclosure Agreement between the parties dated 9 May 2005 concerning the subject matter of
this Agreement, a copy of which is attached hereto as Exhibit B, except to the extent that the
terms of such nondisclosure agreement may conflict with the terms of this Agreement, in which
case the terms of this Agreement shall prevail. The parties further
agree that the mutual obligations of nondisclosure and non-use set forth in such Mutual
Nondisclosure Agreement shall subsist for a period of five (5) years after the termination
of this Agreement.

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-11-

 

	11.2	 	The terms of this Agreement shall be maintained in strict confidence by both MRC and Omeros,
and may not be disclosed by either party without the consent of the other party, except as may
be required under a court order or decree or as required to comply with any governmental law,
rule or regulation, and Omeros may disclose the terms of this Agreement to Omeros’ current and
potential employees, directors, consultants, shareholders, investors and corporate partners.
	 
	12	 	Indemnification
	 
	12.1	 	Each party (the “Indemnifying Party”) shall indemnify, hold harmless and defend the other
party and its employees, officers, directors, consultants and agents (the “Indemnified Party”)
against any and all claims, suits, losses, liabilities, damages, costs, fees, and expenses
(“Claims”) resulting from or arising directly out of the Indemnifying Party’s breach of any
representation, warranty or obligation under this Agreement, or the Indemnifying Party’s
exercise of the rights and obligations under this license or any sublicense, except that such
obligation to indemnify, hold harmless and defend shall not extend to any Claims to the extent
such Claims result from or arise directly from the negligence or misconduct of the Indemnified
Party. This indemnification does not include any indemnity in relation to product performance
or product liability, and furthermore does not include any incidental, consequential or
special damages.
	 
	13	 	Enforcement of Patent Rights
	 
	13.1	 	If either party learns of the infringement of any patent or other intellectual property right
included in the MRC IP or the Joint IP, that party shall promptly notify the other party of
such infringement and will provide the other party with all evidence of infringement in the
notifying party’s possession. Both parties shall use their best efforts in cooperation with
each other to terminate third party infringement without litigation.
	 
	13.2	 	Omeros shall have the sole right at its discretion to enforce the MRC IP and the Joint IP
against third party infringers, including the initiation of any civil action in Omeros’ name,
at Omeros’ sole cost, in which event any award, judgment, settlement or damages collected
shall belong solely to Omeros without duty to account to MRC. In the event that it is
necessary for Omeros to join MRC as a party to any such civil action, MRC shall join such
action for no additional compensation but at Omeros’ sole expense, and any award, judgment,
settlement or damages collected shall belong solely to Omeros without duty to account to MRC.
	 
	13.3	 	If Omeros unreasonably declines to initiate enforcement of the MRC IP and the Joint IP
against any third party infringer within ninety (90) days of a written demand from MRC to do
so, then MRC shall have the sole right at its discretion to enforce the MRC IP and the Joint
IP against such third party infringer, including the initiation of any civil action in
MRC’s name, at MRC’s sole cost, in which event any award, judgment, settlement or
damages collected shall belong solely to MRC without duty to account to Omeros.
	 
	14	 	Term and Termination

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-12-

 

	14.1	 	Unless terminated earlier as set forth in Section 14.2 or 14.3 herein below, this Agreement
shall subsist so long as there is any pending patent application within the MRC IP or the
Joint IP, any patent application in the process of being prepared for filing as agreed to by
Omeros and MRC or any valid and subsisting claim included within any patent, utility model or
inventor’s certificate within the MRC IP or the Joint IP (the “License Term”).
	 
	14.2	 	Omeros may terminate this Agreement by providing ninety (90) days advance written notice of
termination under this Section 14.2 to MRC, with or without cause, at any time [†].
	 
	14.3	 	Either party may terminate this Agreement at any time in the event that the other party (a) breaches any material obligation of this Agreement by first submitting written notice of
breach to the breaching party, which breach is not substantially cured within ninety (90)
days of the receipt of such notice, followed by written notice of termination then being
sent to the breaching party, or (b) declares or is adjudged by a court of competent
jurisdiction to be insolvent, bankrupt or in receivership, and such insolvency, bankruptcy
or receivership materially limits such party’s ability to perform its obligation under this
Agreement, excluding reorganizations entered into by such party with the consent of the
other party, which consent shall not be unreasonably withheld.
	 
	14.4	 	Omeros may at any time terminate its sponsorship of the Sponsored Research by providing
ninety (90) days advance written notice of termination under this Section 14.4 to MRC, for
cause as specified in Section 2.2 above or at any time due to failure to perform any Research
Plan or other breach of this Agreement by MRC, or without cause as specified in, and subject
to reimbursement of any severance fees that may be payable in accordance with, Section 2.2
above, in which event Sections 2.1 — 2.3 herein shall cease to be effective, and Sections 2.4
and 2.5 shall cease to be effective after all reports are provided and accepted and all
payments are made for Sponsored Research performed in accordance with the applicable Research
Plan prior to such notice, but the remainder of this Agreement shall continue in full force
and effect for the License Term, including all rights and obligations of both parties
hereunder. In the event of Omeros’ termination of its sponsorship of the Sponsored Research,
Omeros shall pay to MRC any and all non-cancelable sums reasonably incurred or committed to by
MRC prior to receipt of the notice of termination.
	 
	14.5	 	The provisions of Sections 2.6 (Publication), 3 (Ownership of Intellectual Property), 4.2 —
4.6 (License as applicable to Joint IP and right of first refusal), 8 (Patent Prosecution as
applicable to Joint IP), 9 and 10 (Representations and Warranties and Other Obligations), 11
(Confidentiality), 12 (Indemnification), 13 (Enforcement as applicable to Joint IP), 15 (Use
of Names) and 16 (Miscellaneous) above shall survive expiration or termination of
this Agreement for the period set forth therein or, if no period is set
forth therein, then indefinitely.
	 
	15	 	Use of Names
	 
	15.1	 	Nothing contained in this Agreement confers any right to either party to use in

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-13-

 

advertising, publicity, or other promotional activities any name, trade name, trademark, or other
designation of the other party hereto, and neither party shall make such use without the prior
written consent of the other party, provided however Omeros may through written, oral or
electronic communication disclose the existence of this Agreement and the names of MRC, Dr.
Reid, Mr. Willis and other of MRC’s employees and consultants to Omeros’ current and potential
employees, directors, consultants, shareholders, investors and corporate partners, and as
required to comply with any governmental law, rule or regulation.

	16	 	Miscellaneous
	 
	16.1	 	This Agreement including all appendices and exhibits attached thereto or incorporated by
reference therein constitutes the entire understanding of the parties hereto regarding the
subject matter of this Agreement, and no other representation, agreement, promise or
undertaking altering, modifying, taking from or adding to the terms of this Agreement shall
have any effect unless the same is reduced to writing and duly executed by the parties hereto.
In the event of any conflict between the main body of this Agreement and any attachments
thereto or documents incorporated by reference therein, the provisions of the main body of
this Agreement shall control.
	 
	16.2	 	Either party’s failure to enforce any provision of this Agreement will not be considered a
waiver of future enforcement of that or any other provision.
	 
	16.3	 	The laws of the state of Delaware, United States, without regard to its conflict-of-laws
provisions, shall govern this Agreement, its interpretation and its enforcement, and any
disputes arising out of or related to this Agreement.
	 
	16.4	 	The parties agree that, except as provided herein below, any claim or controversy arising out
of or relating to this Agreement or breach thereof shall be settled by arbitration in the
state of Delaware, United States, in accordance with the commercial rules of the American
Arbitration Association by a panel of three arbitrators, one selected by each party and the
third selected by the other two arbitrators. In any such arbitration proceeding, judgment
upon the award rendered by the arbitrator shall be final and binding upon the parties and may
be entered by either party in any court or forum of competent jurisdiction as provided herein
below. Notwithstanding the foregoing, both parties agree that any claims or controversies
concerning the validity or enforceability of any intellectual property, or the actual or
threatened disclosure or misuse of confidential information, may alternately be resolved by a
civil action in any court of competent jurisdiction as provided herein below, and both parties
further agree that each shall retain the right to seek injunctive relief in any court of
competent jurisdiction as provided herein
below to prevent a breach, threatened breach or continuing breach of this Agreement which
would cause irreparable injury (e.g., breaches of confidentiality or the like).
	 
	16.5	 	Any civil action prosecuted or instituted by either party as permitted herein above with
respect to any matters arising out of or related to this Agreement shall be brought in either
the United States District Court located in the state of Delaware, United States (if

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-14-

 

federal subject matter jurisdiction therein lies) or the Superior Court for the state of Delaware,
United States (if there is no subject matter jurisdiction in federal court), and each party
hereby consents to the jurisdiction and venue of such courts for such purposes.

	16.6	 	In the event that it is necessary for either party of this Agreement to take legal action to
enforce any of the terms, conditions or rights contained herein, or to defend any such action,
then the prevailing party in such action shall be entitled to recover from the other party all
reasonable attorneys fees, costs and expenses related to such legal action.
	 
	16.7	 	In the event that any portion of this Agreement is held invalid or unenforceable by a court
of law, that provision will be construed and reformed to permit enforcement of the provision
to the maximum extent permissible consistent with the parties’ original intent, and if such
construction is not possible, such provision shall be struck from this Agreement, and the
remainder of the Agreement shall remain in full force and effect as if such provision had
never been part of this Agreement.
	 
	16.8	 	For the purposes of this Agreement, the parties hereto are independent contractors, and
nothing in this Agreement shall be construed to place them in the relationship of partners,
principal and agent, employer/employee or joint venturers. Except as provided expressly
herein, each party agrees that it shall have no authority to bind or obligate the other party,
nor shall any party hold itself out as having such authority.
	 
	16.9	 	Neither party will be liable for failure or delay in performing any obligation under this
Agreement, or will be considered in breach of this Agreement, if such failure or delay is due
to a natural disaster or any cause reasonably beyond such party’s control, provided that such
party resumes performance as soon as possible following the end of the event that caused such
delay or failure of performance.
	 
	16.10	 	Neither party may assign this Agreement, or any obligation or right under this Agreement, in
whole or in part, without the other party’s prior written consent, which consent will not be
unreasonably withheld. This Section shall not be construed in any way to limit Omeros’ rights
to grant, at Omeros’ sole discretion, sublicenses hereunder. MRC consents to Omeros’
assignment of this Agreement in whole or in part in connection with the merger, consolidation
or transfer of all or substantially all of that portion of Omeros’ assets to which this
Agreement relates. Subject to these restrictions, this Agreement will be binding upon and
will inure to the benefit of the parties’ permitted successors and assignees.
	 
	16.11	 	Any notice required or permitted to be given hereunder by either party shall be in writing
and shall be (a) delivered personally, (b) sent by registered mail, return receipt requested,
postage prepaid, (c) sent by an internationally recognized courier service guaranteeing
next-day delivery, charges prepaid, or (d) delivered by facsimile (with the original
promptly sent by any of the foregoing manners) to the addresses or facsimile numbers of the
other party set forth below, or at such other addresses as may from time to time be
furnished by similar notice by either party. The effective date of any notice hereunder
shall be the date of receipt by the receiving party.

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-15-

 

	 	 	 
	If to Omeros:

	 	If to MRC:
	 
	 	 
	Omeros Corporation

	 	Medical Research Council
	1420 Fifth Avenue, Suite 2600

	 	20 Park Crescent
	Seattle, WA 98101

	 	London
	U.S.A.

	 	United Kingdom
	 

	 	W1B 1AL
	 
	 	 
	Attention: Gregory A. Demopulos, M.D.,

	 	Attention: Graham Wagner,
	                 Chairman & CEO

	 	Associate Director Licensing
	 

	 	and Agreements
	 
	 	 
	And copy to: Marcia S. Kelbon,
	 	 
	                      Patent & General Counsel
	 	 
	 
	 	 
	Fax: (206) 264.7856 

	 	Fax: +44.207.291.5325 
	Phone: (206) 623.4688 

	 	Phone: +44.207.291.5317 

	16.12	 	This Agreement may be executed in one or more counterparts, each of which will be considered
an original, and all of which will constitute the same instrument.

     IN WITNESS WHEREOF, Omeros and MRC have each acknowledged and accepted this Agreement by
causing it to have been signed by their respective duly authorized officials.

	 	 	 	 	 	 	 	 	 
	OMEROS CORPORATION	 	MEDICAL RESEARCH COUNCIL	 	 
	 
	 	 	 	 	 	 	 	 
	By:

	 	/s/ Gregory A. Demopulos
	 	By:
	 	/s/ Graham Wagner	 	 
	 

	 	 

	 	 
	 	 

	 	 
	 
	 	 	 	 	 	 	 	 
	Name:

	 	Gregory A. Demopulos, M.D.
	 	Name:
	 	Graham Wagner	 	 
	 

	 	 	 	 	 	 

	 	 
	 
	 	 	 	 	 	 	 	 
	Title:

	 	Chairman & CEO
	 	Title:
	 	Associate  Director  Licensing Agreements	 	 
	 	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Date:

	 	11/16/07 
	 	Date:
	 	10th November 2005	 	 
	 
	 	 	 	 	 	 	 	 
	Fax:

	 	206.264.7856 
	 	Fax:
	 	+44 207 291 5325 	 	 

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-16-

 

The above Exclusive License and Sponsored Research Agreement is acknowledged by the
undersigned investigators, who agree to abide by the terms set forth therein.

	 	 	 	 	 	 	 	 	 
	PROFESSOR KENNETH B. M. REID	 	ANTHONY C. WILLIS	 	 
	 
	 	 	 	 	 	 	 	 
	Signed:

	 	 	 	Signed:	 	 	 	 
	 

	 	 

	 	 	 	 

	 	 
	Title:

	 	Director, MRC Immunochemistry Unit
	 	Title:	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Date:

	 	 	 	Date:	 	 	 	 
	 

	 	 

	 	 	 	 

	 	 
	Fax:

	 	 	 	Fax:	 	 	 	 
	 

	 	 

	 	 	 	 

	 	 

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-17-

 

EXHIBIT A

To the Exclusive License and Sponsored Research Agreement

Between Omeros Corporation and the Medical Research Council

RESEARCH PLAN

Sponsor: Omeros Corporation

Research Institution: Medical Research Council (MRC)

Investigator: Dr. Ken Reid

Research Period: First year, commencing 1 November 2005

Research Aims and Activities

     Attachment 1 hereto sets for the research aims of the Sponsored Research program to be
completed during the first year. All activities to meet specific aim 1 are to be carried out by
MRC (“Dr. Reid’s lab”). Aims indicated as to be performed by Omeros or third parties, and all
animal models in specific aim 5, are provided herein for reference purposes only and shall not be
interpreted as any obligation on the part of Omeros or MRC. Specific aims and the corresponding
timeline may be modified as mutually agreed in writing by Dr. Ken Reid and Omeros.

Budget

     The total consideration to be paid to MRC for all Sponsored Research to be carried out during
the first through third years of the Sponsored Research Term, including without limitation full and
complete payment for all services, materials, facilities, overhead and indirect costs, but
excluding reimbursement for any legally required severance that may be payable as provided for is
Section 2.2 of this Agreement above, is as follows:

     Year 1 (1 November 2005 — 31 October 2006):

                 [†]

     Year 2 (1 November 2006 — 31 October 2007):

                 [†]

     Year 3 (1 November 2007 — 31 August 2008):

                 [†]

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-18-

 

EXHIBIT B

To the Exclusive License and Sponsored Research Agreement

Between Omeros Corporation and Medical Research Council

MUTUAL CONFIDENTIALITY AGREEMENT

OMEROS CORPORATION

MUTUAL CONFIDENTIALITY AGREEMENT

          This Confidentiality Agreement (“Agreement”) is entered into as of 9 May 2005 by and between
OMEROS CORPORATION (“Omeros”), 1420 FIFTH AVENUE, SUITE 2600, SEATTLE WA 98101 USA and MEDICAL
RESEARCH COUNCIL (“MRC”), 20 PARK CRESCENT, LONDON, UNITED KINGDOM, W1B 1AL.

     In the course of business negotiations and transactions between the parties hereto, either or
both parties and certain agents thereof (including without limitation, attorneys and consultants
representing the parties) may disclose certain confidential and proprietary information pertaining
to the mammalian gene and/or protein referred to as ‘mannan-binding lectin serine protease 2’ or
‘MASP-2’ as located, for example, on human chromosome 1p, the 19 kDa N-terminal CUB1-EGF domains of
MASP-2 referred to as MAp19, as well as patent applications, license and research agreements, and
research data concerning the same, for the sole purpose of evaluating a potential business
relationship and/or performing in accordance with an agreement between the parties (“Purpose”).
The parties want to provide for the protection of any such confidential and proprietary information
disclosed by one party (the “disclosing party”) to which the other party receiving the information
(the “recipient”) may have access. In consideration of continuing negotiations for or entering
into business transactions, the parties agree:

     1. Covenant Not to Disclose. For a period of at least five years from the date of last
disclosure hereunder, the recipient of any Confidential Information will not at any time disclose
or otherwise make known or available to any person, firm, corporation or other entity, or use for
its own account or for any purpose other than the Purpose, any Confidential Information disclosed
by the other party prior to or during the term of this Agreement, without the express prior written
consent of the disclosing party. The recipient shall utilize reasonable procedures to safeguard
Confidential Information, including releasing Confidential Information only to employees or
consultants who have agreed to abide by the recipient’s obligations hereunder on a “need-to-know”
basis.

     2. Confidential Information.

     2.1 For information disclosed by Omeros, “Confidential Information” means any and all
information relating to: (a) methods and pharmaceuticals or other agents to inhibit pain and
inflammation, cartilage loss, vasospasm, smooth muscle spasm, restenosis, or tumor cell adhesion,
and/or to accelerate recovery of joint motion and function, for use in surgical procedures
(including without limitation arthroscopic,

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-19-

 

			
	cardiovascular, urologic and general surgical procedures), other medical procedures, and/or
for treatment of cartilaginous disorders, which have been developed or are owned or held by Omeros;
(b) drug delivery systems and methods, which have been developed or are owned or held by Omeros;

(c) methods, antibodies and other agents and compositions for the inhibition of the complement
immune system, which have been developed or are owned or held by Omeros, and includes, without
limitation, research and development information, know-how, inventions, trade secrets, technical
data, formulae, treatment methods, license agreements, clinical trial design criteria, protocols,
investigators’ brochures, models, samples, processes, chemistry, manufacturing and controls
information, regulatory information, and any type of product development, business, marketing or
legal plans or strategies or financial information.

     For information disclosed by MRC, “Confidential Information” means any and all information
relating to MASP-2: methods, antibodies and other agents and compositions for the inhibition of the
complement immune system in relation to MASP-2, which have been developed or are owned or held by
MRC, and includes, without limitation, research and development information, know-how, inventions,
trade secrets, technical data, formulae, treatment methods, license agreements, models, samples,
processes, and any type of business, marketing or legal plans or strategies or financial
information.

     2.2 Confidential Information does not include information that the recipient can establish:

     2.2.1 is or becomes generally available to the public other than as a result of a disclosure
by the recipient;

     2.2.2 was in the possession of the recipient prior to its being furnished to the recipient
under this Agreement, provided that the source of such information was not known to the recipient
to be bound by a confidentiality agreement with, or other contractual, legal, or fiduciary
obligation of confidentiality to the disclosing party or any other party with respect to such
information;

     2.2.3 becomes available to the recipient on a non-confidential basis from a source other than
the disclosing party, provided that such source is not bound by a confidentiality agreement with,
or other contractual, legal, or fiduciary obligation of confidentiality to the disclosing party or
any other party with respect to such information; or

     2.2.4 was independently developed by the recipient without reference to the Confidential
Information, provided that such independent development can reasonably be proven by the recipient
by written records.

     2.3 If the recipient is required by order of a court of law, administrative agency, or other
governmental body to disclose any of the Confidential Information, the recipient will promptly
provide the disclosing party with reasonable advance written notice if at all possible to enable
the disclosing party the opportunity to seek a protective order or to otherwise prevent or limit
such legally required disclosure, will use reasonable efforts to cooperate with the disclosing
party to obtain such protection, and
will disclose only the legally required portion of the Confidential Information. Any such

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-20-

 

legally required disclosure will not relieve recipient from its obligations under this Agreement to
otherwise limit the disclosure and use of such information as Confidential Information.

     3. Limitations on Use. In further recognition of the value of Confidential Information, the
recipient acknowledges that it shall not engage in the reproduction of Confidential Information
through the techniques of “reverse engineering”. The recipient shall not make any use, either
directly or indirectly, of any Confidential Information to which the recipient has been, is or will
be exposed, except in the ordinary course of business pursuant to this Agreement for the Purpose or
as may be expressly authorized in a separate specific written agreement between the parties.
Nothing in this Agreement shall be construed as giving recipient any license or other right under
any intellectual property of the disclosing party. Neither party shall disclose the existence and
nature of this Agreement or the fact that it is evaluating the other party’s Information, except
that such disclosure to a party’s present and potential employees, consultants, officers,
directors, shareholders and investors is permitted, and neither party shall use the name of the
other party in any publicity or advertising without that party’s prior written approval.

     4. Return of Confidential Information. When requested by the disclosing party or at the
termination of the relationship giving rise to this Agreement, whichever first occurs, the
recipient immediately shall deliver all Confidential Information and all copies thereof in its
possession or in the possession of its employees, provided that the recipient’s legal counsel may
retain one archival copy of the Confidential Information solely for purposes of ensuring compliance
with this Agreement.

     5. Specific Performance. The parties acknowledge that (a) the covenants set forth in Sections
1, 3 and 4 are essential elements of the transactions contemplated in this Agreement and that, but
for the agreement to comply with such covenants, the parties would not have entered into such
transactions, and that the parties have consulted with, or have had the opportunity to consult
with, counsel and have been advised in all respects concerning the reasonableness of such covenants
as to scope and limit of time; (b) the disclosing party will not have any adequate remedy at law if
the recipient violates the terms of Sections 1, 3 and 4 fails to perform any of its other
obligations hereunder; and (c) the disclosing party shall have the right, in addition to any other
rights it may have, to obtain in any court of competent jurisdiction temporary, preliminary and
permanent injunctive relief to restrain any breach, threatened breach, or otherwise to specifically
enforce any of such covenants or any other obligations of the recipient if the recipient fails to
perform any of its obligations under this Agreement.

     6. Term. This Agreement and the obligations of nondisclosure and nonuse set forth herein
shall terminate five (5) years after the date of the last disclosure of Confidential Information
under this Agreement. Prior to termination of this Agreement, either party may deliver written
notice to the other party that it no longer wishes to receive Confidential Information under this
Agreement, after receipt of which any information subsequently sent in writing or orally disclosed
by either party shall be deemed non-confidential.

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-21-

 

     7. Miscellaneous. This Agreement shall be binding upon and inure to the benefit of the
parties’ successors and assigns. The waiver of any breach of any provision of this Agreement or
failure to enforce any provision hereof shall not operate or be construed as a waiver of any
subsequent breach by any party. The invalidity of all or any part of any section of this Agreement
shall not render invalid the remainder of this Agreement or the remainder of such section. If any
provision of this Agreement is so broad as to be unenforceable, such provision shall be interpreted
to be only so broad as is enforceable. In any litigation or disputes arising out of this
Agreement, the substantially prevailing party will be entitled to recover all reasonable costs and
attorneys’ fees, including costs and fees on appeal. The provisions of this Agreement shall not be
construed as limiting any rights or remedies that either party may otherwise have under the
applicable law.

     8. Governing Law. This Agreement shall be governed by and construed in accordance with the
laws of the State of Delaware.

     DATED as of 9 May 2005.

	 	 	 	 	 	 	 	 	 	 	 
	 	 	OMEROS CORPORATION	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	 

	 	By 	 	 	 	 	 	 	 	 
	 	 	 	   
	 
	 	 	 	 	 	 	 	 	 	 
	 

	 	 	 	 	Its 		 	 	 	 
	 	 	 	 	 	 	  
	 
	 	MEDICAL RESEARCH COUNCIL	 	 
	 
	 	 	 	 	 	 	 	 	 	 	 
	 

	 	By 		 	 	 	 	 	 	 	 
	 	 	 	 	   
	 
	 	 	 	 	 	 	 	 	 	 	 
	 

	 	 	 	 	Its 		 	 	 	 
	 	 	 	 	 	 	  

 

			
	†	 	DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION

-22-

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00163-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00163-of-00352.parquet"}]]