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  Exhibit 10.5.2    
    

 
    THIRD AMENDMENT TO LEASE    
    

        THIS THIRD AMENDMENT TO LEASE ("Amendment") is made and entered into as of the
28th day of November 2003, by and between CATELLUS DEVELOPMENT CORPORATION, a Delaware corporation ("Landlord"), and ALLOS
THERAPEUTICS, INC., a Delaware corporation ("Tenant"). 

 
 

R E C I T A L S :    

        A.    Landlord
and Tenant entered into that certain Office Lease dated as of April 4, 2001 (the "Original Lease"), as
amended by that certain First Amendment to Lease and Commencement Date Memorandum dated as of November 1, 2002 ("First Amendment"), that certain
Second Amendment to Lease dated November 12, 2002 ("Second Amendment"), and that certain Amended and Restated Second Amendment to Lease dated
December 9, 2002 ("Restated Second Amendment"), whereby Tenant leased certain office space in the building located at 11080 CirclePoint Road in
Westminster, Colorado. The Original Lease, as amended by the First Amendment, Second Amendment and Restated Second Amendment, is referred to herein as the
"Lease." 

        B.    By
this Amendment, Landlord and Tenant desire to expand the Premises and to otherwise modify the Lease as provided herein. 

        C.    Unless
otherwise defined herein, capitalized terms as used herein shall have the same meanings as given thereto in the Lease. 

        NOW,
THEREFORE, in consideration of the foregoing recitals and the mutual covenants contained herein, and for other good and valuable consideration, the receipt and sufficiency of which
are hereby acknowledged, the parties hereto agree as follows: 

 
 

A G R E E M E N T :    

        1.    The Existing Premises.    Landlord currently leases to Tenant that certain office space containing 43,377
rentable square feet located on the ground and second (2nd) floors of the Building (the "Existing Premises"). 

        2.    Expansion of the Premises.    That certain space located on the ground floor of the Building consisting of
approximately 579 rentable square feet, as outlined on the floor plan attached hereto as Exhibit A and made a part hereof, is referred to herein
as the "Expansion Space." Tenant shall lease the Expansion Space effective as of March 1, 2004 (the "Expansion
Commencement Date"). Accordingly, effective upon the Expansion Commencement Date, the Existing Premises shall be increased to include the Expansion Space. Such addition of the
Expansion Space to the Existing Premises shall, effective as of the Expansion Commencement Date, increase the number of rentable square feet leased by Tenant in the Building to a total of 43,956
rentable square feet, subject to verification pursuant to Section 3 below. Effective as of the Expansion Commencement Date, all references in the Lease to the "Premises" shall mean and refer to
the Existing Premises as expanded by the Expansion Space. The period from the Expansion Commencement Date through the Expiration Date is referred to herein as the "Expansion
Term". 

        3.    Verification of Rentable Square Footage.    The rentable square footage of the Expansion Space shall be subject
to verification in accordance with the provisions of Section 2.1 of the Original Lease, except that Landlord shall cause its space measurement consultant to provide such verification within
thirty (30) days following the Expansion Commencement Date. If such verification results in a rentable square footage of the Expansion Space that is different than that set forth in
Section 2 above, then the parties shall further amend the Lease to modify all amounts, percentages and figures appearing or referred to in this Amendment to conform to such corrected rentable
square footage (including, without limitation, the Base Rent, and Tenant's Percentage Share and the TI Allowance). 

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        4.    Base Rent.    During the Expansion Term, and in addition to the Base Rent for the Existing Premises, Tenant
shall pay Base Rent for the Expansion Space as follows (although Base Rent for the Existing Premises and the Expansion Space are separately identified, such amounts shall be a single and
non-severable rental obligation): 

 

											
	Period of Expansion Term

 
	 	Annual Base Rent Per

Rentable Square Foot 	 	Annual Base Rent 	 	Monthly Base Rent 	 
	 3/01/04 - 3/31/04
	 	$	13.00	 	$	7,527.00	 	$	627.25	 
	 4/1/04 - 9/30/06
	 	$	13.50	 	$	7,816.50	 	$	651.38	 
	 10/1/06 - 10/31/08
	 	$	14.50	 	$	8,395.50	 	$	699.63	 

 

         5.    Tenant's Percentage Share.    Commencing on July 1, 2003, and continuing thereafter during the Expansion
Term, Tenant's Percentage Share shall be increased to 29.10%. 

        6.    Exclusion of Variable Operating Expenses.    Operating Expenses attributable to the Expansion Space shall
exclude those Operating Expenses that vary with occupancy, such as janitorial expenses and utility costs (other than those attributable to the Common Facilities), until the Tenant Improvements (as
defined in Exhibit B) are substantially completed in all or any portion of the Expansion Space. 

        7.    Tenant Improvements.    The Tenant Improvements (as defined in  Exhibit B) in the Expansion Space shall be installed and
constructed in accordance with the terms of the Tenant Work Letter attached hereto as  Exhibit B and made a part hereof. The parties acknowledge that there is no required time schedule to construct
the Tenant Improvements, and
Tenant shall, subject to Landlord's reasonable approval, be entitled to designate when the Tenant Improvements are to be constructed. Tenant acknowledges that construction of the Tenant Improvements
may occur during the Expansion Term and that the performance of such work shall not be deemed a constructive eviction nor shall Tenant be entitled to any abatement of Rent in connection therewith. In
addition, Landlord shall not be liable for any
damage to property, injury to persons or damage to Tenant's business caused by the construction of the Tenant Improvements during the Expansion Term. 

        8.    Parking.    During the Expansion Term, Tenant shall rent from Landlord an additional two (2) parking
spaces for use in the Building's parking facility. Tenant's rental and use of such additional parking spaces shall be in accordance with, and subject to, all provisions of Section 2.4 of the
Original Lease. 

        9.    Brokers.    Each party represents and warrants to the other that no broker, agent or finder negotiated or was
instrumental in negotiating or consummating this Amendment other than Equis Corporation and CB Richard Ellis ("Brokers"). Landlord shall pay a brokerage
commission to Brokers in accordance with separate agreements between and Landlord and Brokers. Subject to the foregoing, each party agrees to defend, indemnify and hold harmless the other party from
and against any claim for a commission or finder's fee by any person or entity who claims or alleges that they were retained or engaged by the indemnifying party or at the request of such party in
connection with this Amendment. 

        10.    Tenant Representations.    Each person executing this Amendment on behalf of Tenant represents and warrants to
Landlord that, and Tenant shall, at Landlord's request, provide Landlord with evidence that: (a) Tenant has full right and authority to enter into this Amendment and to perform all of Tenant's
obligations hereunder; and (b) each person signing this Amendment on behalf of Tenant is duly and validly authorized to do so. 

        11.    No Further Modification.    Except as set forth in this Amendment, all of the terms and provisions of the Lease
shall apply with respect to the Expansion Space and shall remain unmodified and in full force and effect. Effective as of the date hereof, all references to the
"Lease" shall refer to the Lease as amended by this Amendment. 

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        IN
WITNESS WHEREOF, this Amendment has been executed as of the day and year first above written. 

							
	 	 	"Landlord":
	

 	
 	
CATELLUS DEVELOPMENT CORPORATION,

a Delaware corporation
	

 	
 	
By:	
 	
Catellus Commercial Development

Corporation, a Delaware corporation
	 	 	 	 	Its: Agent
	

 	
 	
By:	
 	
/s/ John Bezzant

 
	 	 	 	 	Name:	 	John Bezzant

 
	 	 	 	 	Its:	 	Vice President

 
	

 	
 	
"Tenant":
	

 	
 	
ALLOS THERAPEUTICS, INC.,

a Delaware corporation
	

 	
 	
By:	
 	
/s/ Michael E. Hart

 
	 	 	 	 	Name:	 	Michael E. Hart

 
	 	 	 	 	Its:	 	President/CEO

 
	

 	
 	
By:	
 	

 
	 	 	 	 	Name:	 	

 
	 	 	 	 	Its:	 	

 

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  EXHIBIT A
  
    OUTLINE OF EXPANSION SPACE    
    

  

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  EXHIBIT B    
    

 
    TENANT WORK LETTER    
    

        This Work Letter ("Work Letter") is attached to the Amendment as  Exhibit B and
incorporated into the Amendment by reference. Capitalized terms used herein and not defined herein shall have the respective
meanings set forth in the Lease. 

        1.    Landlord's Work.    Landlord has constructed the Building in accordance with the plans and specifications
described in Schedule 1 attached hereto. 

        2.    Tenant Improvements.    

        2.1    TI Allowance.    Tenant shall be entitled to a one-time tenant improvement allowance (the
"TI Allowance") in the amount of Thirty Dollars ($30.00) per rentable square foot of the Expansion Space for the costs relating to the initial design
and construction of Tenant's improvements that are permanently affixed to the Expansion Space (the "Tenant Improvements"). In no event shall Landlord be
obligated to make disbursements pursuant to this Work Letter in a total amount which
exceeds the TI Allowance. Provided the Tenant Improvements are constructed and are consistent with the improvements in the Existing Premises, Tenant shall be entitled to a credit against Base Rent
first payable for the Expansion Space in an amount equal to any unused portion of the TI Allowance. 

        2.2    Disbursement of the TI Allowance.    Except as otherwise set forth in this Work Letter, the TI Allowance shall
be disbursed by Landlord (each of which disbursements shall be made pursuant to Landlord's disbursement process), only for the following items and costs (collectively, the "TI
Allowance Items"): (a) payment of the fees of the "Architect" and the "Engineers," as those terms are defined in Section 2.3 of this Work Letter, and payment of
the fees incurred by, and the cost of documents and materials supplied by, Landlord and Landlord's consultants in connection with the preparation and review of the "Working Drawings," as that term is
defined in Section 2.3 of this Work Letter; (b) the payment of plan check, permit and license fees relating to construction of the Tenant Improvements; (c) the cost of
construction of the Tenant Improvements; (d) the cost of any changes in the base, shell and core of the Building when such changes are required by the Working Drawings (including if such
changes are due to the fact that such work is prepared on an unoccupied basis) or are otherwise required by Applicable Law as a result of the construction of the Tenant Improvements, such cost to
include all direct architectural and/or engineering fees and expenses incurred in connection therewith; (e) the cost of any changes to the Working Drawings or Tenant Improvements required by
Applicable Law; (f) sales and use taxes and/or applicable fees; (g) "Landlord's Supervision Fee," as that term is defined in Section 2.10 of this Work Letter; (h) all other
costs to be expended by Landlord in connection with the construction of the Tenant Improvements; and (i) one-half (1/2) of the costs of the demising walls between the
Expansion Space and any other tenant space in the Building's ground floor lobby. 

        2.3    Building Specifications.    Landlord may establish specifications for the Building-standard components to be
used in the construction of the Tenant Improvements in the Expansion Space (collectively, the "Building Specifications"), which shall be available to
Tenant upon request. Tenant shall utilize materials and finishes that comply with the Building Specifications and Tenant shall not substitute any such materials or finishes without Landlord's prior
written consent. Landlord may make changes to the Building Specifications from time to time. 

        2.3.1    Selection of Architect/Working Drawings.    Conditioned upon Landlord's reasonable approval of a contract for
services, Tenant shall retain Ware Malcomb Architects or such other architect reasonably acceptable to Landlord (the "Architect") to prepare the
"Working Drawings," as that term is defined in this Section 2.3.1 below. Landlord shall retain Landlord's designated engineering consultants (the
"Engineers") to prepare all plans and engineering 

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working
drawings relating to the structural, mechanical, HVAC/lifesafety, electrical, plumbing, and sprinkler work in the Expansion Space. The plans and drawings to be prepared by the Architect
hereunder shall be known collectively as the "Working Drawings" and the plans and drawings to be prepared by the Engineers hereunder shall be known
collectively as the "Engineering Drawings." Notwithstanding that Landlord has retained the Engineers to prepare the Engineering Drawings and that
Landlord shall review the Working Drawings required hereunder, Landlord shall have no liability whatsoever in connection therewith and shall not be responsible for any omissions or errors contained in
the Working Drawings or the Engineering Drawings. 

        2.3.2    Selection of Contractor.    Landlord shall retain a contractor
("Contractor") designated by Landlord and reasonably approved by Tenant to construct the Tenant Improvements. The Contractor shall subcontract with
Landlord's designated subcontractors for any and all mechanical, electrical plumbing, HVAC/lifesafety, and sprinkler systems. Tenant shall be permitted to participate with Landlord in the process of
selecting the Contractor. 

        2.4    Final Space Plan.    Tenant and the Architect shall prepare the final space plan for Improvements in the
Expansion Space (collectively, the "Final Space Plan"), which Final Space Plan shall include a layout and designation of all offices, rooms and other
partitioning, their intended use, and equipment to be contained therein, and shall deliver the Final Space Plan to Landlord for Landlord's approval or reasonable disapproval, which approval or
reasonable disapproval shall be delivered by Landlord to Tenant no later than five (5) business days after Landlord's receipt of such Final Space Plan. If Landlord reasonably disapproves of any
portion of the Final Space Plan, the parties shall meet, within five (5) days after Landlord's disapproval, to agree upon revisions to be made to the Final Space Plan to meet the reasonable
satisfaction of Landlord. The Architect shall then revise the Final Space Plan to the form agreed upon in such meeting and Landlord shall then approve or reasonably disapprove the revised Final Space
Plan in writing no later than five (5) business days after Landlord's receipt of such revised Final Space Plan. If Landlord shall again reasonably disapprove the revised Final Space Plan, the
parties will revise and review the Final Space Plan again in accordance with the procedure set forth above until Landlord's reasonable approval is obtained. 

        2.5    Final Working Drawings.    Tenant and the Architect shall complete the architectural drawings for the Expansion
Space, and the Architect shall compile a fully coordinated set of architectural working drawings in a form which is complete to allow subcontractors to bid on the work and to obtain all applicable
permits (collectively, the "Final Working Drawings") and shall submit the same to Landlord for Landlord's approval or reasonable disapproval, which
approval or reasonable disapproval shall be delivered by Landlord to Tenant no later than five (5) business days after Landlord's receipt of such Final Working Drawings. If Landlord reasonably
disapproves of any portion of the Final Working Drawings, the parties shall meet, within five (5) days after Landlord's disapproval, to agree upon revisions to be made to the Final Working
Drawings to meet the reasonable satisfaction of Landlord.
The Architect shall then revise the Final Working Drawings to the form agreed upon in such meeting. Landlord shall then approve or reasonably disapprove the revised Final Working Drawings no later
than five (5) business days after Landlord's receipt of such revised Final Working Drawings. If Landlord shall again reasonably disapprove the revised Final Working Drawings, the parties will
revise and review the Final Working Drawings again in accordance with the procedure set forth above until Landlord's reasonable approval is obtained. 

        2.6    Approved Working Drawings.    The Final Working Drawings approved by Landlord and Tenant and the Engineering
Drawings shall be referred to herein collectively as (the "Approved Working Drawings") and Tenant shall submit the same to the appropriate governmental
entities for all applicable building permits necessary to allow the Contractor to pull the applicable building 

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permits
and commence and fully complete the construction of the Tenant Improvements (the "Permits"). If Tenant desires any change, modification or
alteration in the Approved Working Drawings, Tenant must first obtain the prior written consent of Landlord. Prior to commencing any change requested by Tenant to the Approved Working Drawings,
Landlord shall prepare and deliver to Tenant, for Tenant's approval, a change order ("Change Order") setting forth the additional time required to
perform the change and the total cost of such change, which shall include associated architectural, engineering and Contractor's fees. If Tenant fails to approve such Change Order in writing within
two (2) business days after such delivery by Landlord, Tenant shall be deemed to have withdrawn the Change Order and Landlord shall not proceed to perform the change but will continue with
construction in accordance with the Approved Working Drawings. 

        2.7    Time Deadlines.    Tenant shall cooperate with (i) the Architect, the Engineers, and Landlord to
complete all phases of the Working Drawings, the Engineering Drawings and the permitting process, and (ii) the Contractor, for approval of the "Cost Proposal," as that term is defined in
Section 2.8, below, in accordance with the dates set forth herein. Tenant shall meet with Landlord on a weekly basis to discuss Tenant's progress in connection with the same. The applicable
dates for approval of items, plans and drawings and selection of a contractor as described in this Work Letter are referred to herein as the "time
deadlines." Tenant agrees to comply with the time deadlines. 

        2.8    Cost Proposal.    After the Approved Working Drawings are approved by Landlord and Tenant, Landlord shall
provide Tenant with a cost proposal in accordance with the Approved Working Drawings, which cost proposal shall include, as nearly as possible, the cost of all TI Allowance Items to be incurred by
Tenant in connection with the construction of the Tenant Improvements (the "Cost Proposal"). Landlord does not guaranty the accuracy of the Cost
Proposal. Notwithstanding the
foregoing, portions of the cost of the Tenant Improvements may be delivered to Tenant as such portions of the Tenant Improvements are priced by Contractor (on an individual
item-by-item or trade-by-trade basis), even before the Approved Working Drawings are completed (the "Partial Cost
Proposal"). Tenant shall either (i) approve and deliver the Cost Proposal to Landlord within five (5) business days of the receipt of the same (or, as to a
Partial Cost Proposal, within two (2) business days of receipt of the same), or (ii) notify Landlord within five (5) business days after Tenant's receipt of the Cost Proposal (or
Partial Cost Proposal, as the case may be) that Tenant desires to revise the Approved Working Drawings to reduce the amount of the Cost Proposal (or Partial Cost Proposal, as the case may be), in
which case such changes shall be made to the Approved Working Drawings only in accordance with Section 2.7 above and the revised Working Drawings shall be provided to the Contractor for
repricing whereupon Landlord shall revise the Cost Proposal (or Partial Cost Proposal, as the case may be) for Tenant's approval. This procedure shall be repeated until the Cost Proposal (or Partial
Cost Proposal, as the case may be) is approved by Tenant. The date by which Tenant has approved the Cost Proposal, or the last Partial Cost Proposal, as the case may be, shall be known hereafter as
the "Cost Proposal Delivery Date." The total of all Partial Cost Proposals, if any, shall be known as the Cost Proposal. 

        2.9    Over-Allowance Amount.    The amount that is equal to the difference between (i) the amount
of the Cost Proposal and (ii) the amount of the TI Allowance (less any portion thereof already disbursed by Landlord, or in the process of being disbursed by Landlord, on or before the Cost
Proposal Delivery Date that is not otherwise included within the Cost Proposal) shall be referred to herein as the "Over-Allowance Amount."
Tenant shall pay to Landlord (a) one-half (1/2) of such Over-Allowance Amount no later than ten (10) days after the Cost Proposal Delivery Date and
(b) the other one-half (1/2) of such Over-Allowance Amount within ten (10) days after Landlord gives Tenant written notice that the construction of
the Tenant Improvements is completed. The Over-Allowance Amount shall be disbursed by Landlord prior to the disbursement 

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of
any then remaining portion of the TI Allowance, and such disbursement shall be pursuant to the same procedure as the TI Allowance. In the event that after the Cost Proposal Delivery Date, any
revisions, changes, or substitutions shall be made to the Construction Drawings or the Tenant Improvements, any additional costs which arise in connection with such revisions, changes or substitutions
shall be paid by Tenant to Landlord as an addition to the Over-Allowance Amount as follows: (1) one-half (1/2) of such additional amount within five
(5) days after Landlord's invoice therefor and (2) the remaining one-half (1/2) of such additional amount within five (5) days following Tenant's
receipt of Landlord's written notice that the work to which the change order applies is complete. In addition, upon Landlord's determination of the actual costs incurred by or on behalf of Landlord
for the TI Allowance Items, Tenant shall pay Landlord the amount, if any, by which such actual costs exceed the sum of the TI Allowance and the Over-Allowance Amount within fifteen
(15) days after being billed therefor, or Landlord
may, at its election, require that Tenant deposit with Landlord the full amount of such excess prior to Landlord's delivery of the Expansion Space to Tenant. No portion of the TI Allowance shall be
used to pay Tenant or Tenant's agents, contractors or employees, unless and until Landlord's contractors and any other persons and entities employed by or under contract with Landlord have been paid
in full. 

        2.10    Landlord Supervision.    Landlord shall independently retain Contractor to construct the Tenant Improvements
in accordance with the Approved Working Drawings and the Cost Proposal and Landlord shall supervise the construction by Contractor, and Tenant shall pay a construction supervision and management fee
(the "Landlord Supervision Fee") to Landlord (or its agent) in an amount equal to the product of (i) four percent (4%) and (ii) the
Over-Allowance Amount. 

        2.11    Contractor's Warranties and Guaranties.    Landlord hereby assigns to Tenant all warranties and guaranties by
Contractor relating to the Tenant Improvements, and Tenant hereby waives all claims against Landlord relating to, or arising out of the construction of, the Tenant Improvements. 

        3.    Completion of the Tenant Improvements.    

        3.1    Intentionally Omitted.    

        3.2    Intentionally Omitted    

        3.3    Tenant's Entry Into the Expansion Space Prior to Substantial Completion.    Provided that Tenant and its agents
do not interfere with, or delay, Contractor's work in the Building and the Expansion Space, Contractor shall allow Tenant access to the Expansion Space prior to the substantial completion of the
Expansion Space for the purpose of Tenant installing overstandard equipment or fixtures (including Tenant's data and telephone equipment) in the Expansion Space. Prior to Tenant's entry into the
Expansion Space as permitted by the terms of this Section 3.3, Tenant shall submit a schedule to Landlord and Contractor, for their approval, which schedule shall detail the timing and purpose
of Tenant's entry. Tenant shall hold Landlord harmless from and indemnify, protect and defend Landlord against any loss or damage to the Building or Expansion Space and against injury to any persons
caused by Tenant's actions pursuant to this Section 3.3. 

        3.4    Tenant's Representative.    Tenant has designated Rhonda Gardner as its sole representatives with respect to
the matters set forth in this Work Letter, each of whom shall have full authority and responsibility to act on behalf of the Tenant as required in this Work Letter. 

        3.5    Landlord's Representative.    Landlord has designated Gardiner Hammond as its sole representatives with respect
to the matters set forth in this Work Letter, each of whom, until further notice to Tenant, shall have full authority and responsibility to act on behalf of the Landlord as required in this Work
Letter. 

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        3.6    Time of the Essence.    Unless otherwise indicated, all references herein to a "number of days" shall mean and
refer to calendar days. In all instances where Tenant is required to approve or deliver an item, if no written notice of approval is given or the item is not delivered within the stated time period,
at Landlord's sole option, at the end of said period the item shall automatically be deemed approved or delivered by Tenant and the next succeeding time period shall commence. 

        3.7    Tenant's Lease Default.    Notwithstanding any provision to the contrary contained in this Lease, if an Event
of Default as described in Section 16 of the Lease or this Work Letter has occurred at any time on or before the substantial completion of the Expansion Space or if a circumstance exists that
with the giving of notice, the lapse of time, or both, would constitute an Event of Default under the Lease, then (i) in addition to all other rights and remedies granted to Landlord pursuant
to this Lease, Landlord shall have the right to withhold payment of all or any portion of the TI Allowance and/or Landlord may cause Contractor to cease the construction of the Expansion Space, and
(ii) all other obligations of Landlord under the terms of this Work Letter shall be suspended until such time as such default is cured pursuant to the terms of this Lease. 

        3.8    Tenant's Agents.    All of Tenant's agents, contractors, and subcontractors performing work in, or in
connection with, the Expansion Space (collectively as "Tenant's Agents"), shall be subject to Landlord's reasonable approval and, if deemed necessary by
Landlord to maintain harmony among other labor at the real property or if required by law or any agreement to which Landlord is bound, shall be union labor. 

        3.9    Tenant's Architect's Insurance.    Prior to Tenant's Architect performing any services in connection with the
Tenant Improvements, the Final Space Plan, or the Working Drawings, Tenant shall deliver to Landlord certificates evidencing that Tenant's Architect has in force, with insurance companies reasonably
acceptable to Landlord, (i) Professional Liability Insurance with limits of not less than Five Million Dollars ($5,000,000) per claim and annual aggregate, with a retention of not more than
Fifty Thousand Dollars ($50,000) per claim and an inception date or a retroactive date coinciding with or prior to the earlier of the Effective Date or the date of first performance of Tenant's
Architect's services, (ii) Workers Compensation Insurance as required by state and federal statutes with Employer's Liability Insurance with limits of not less than One Million Dollars
($1,000,000) for bodily injury by accident and One Million Dollars ($1,000,000) for bodily injury by disease, (iii) Commercial General Liability Insurance in the amount of not less than One
Million Dollars ($1,000,000) per occurrence, One Million Dollars ($1,000,000) annual general aggregate, and (iv) Commercial Automobile Liability
Insurance for all owned and non-owned automobiles utilized in connection with the services performed under the Tenant's Architect contract in the amount of not less than One Million
Dollars ($1,000,000) combined single limit for bodily injury and property damage combined. All such insurance required by this Section 3.9 shall be maintained for the entire period during which
services are performed under Tenant's Architect's contract, with the exception of the Professional Liability Insurance policy which shall be maintained in force for at least one (1) year
following substantial completion of the Tenant Improvements. Thereafter, during the second (2nd) and third (3rd) years following substantial completion of the Tenant
Improvements, Tenant's Architect shall maintain Professional Liability Insurance with limits of not less than One Million Dollars ($1,000,000.00) annual aggregate, on a claims made basis, during such
second (2nd) and third (3rd) years after substantial completion of the Tenant Improvements, so long as such insurance is reasonably available under standard policies at
rates comparable to those in effect as of the date of such substantial completion. Landlord shall be named as an additional insured on all required Commercial General Liability policies of Tenant's
Architect, and the required certificate of insurance shall include an additional insured endorsement ISO form number CG 20 10 11 85, or equivalent, evidencing such additional insured 

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status.
All insurance of Tenant's Architect will be primary as respects any insurance of Landlord, which insurance shall be non-contributing. 

        3.10    Insurance Requirements.    All of Tenant's Agents shall carry liability and Products and Completed Operation
Coverage insurance, each in amounts not less than One Million Dollars ($1,000,000.00) per incident, One Million Dollars ($1,000,000.00) in aggregate, and in form and with companies as are required to
be carried by Tenant as set forth in Section 9.2 of the Lease, and the policies therefor shall insure Landlord and Tenant, as their interests may appear, as well as Landlord's contractor, and
shall name as additional insureds all mortgagees of the real property or any other party designated by Landlord. All insurance maintained by Tenant's Agents shall preclude subrogation claims by the
insurer against anyone insured thereunder. Such insurance shall provide that it is primary insurance as respects the Landlord and that any other insurance maintained by Landlord is excess and
noncontributing with the insurance required hereunder. 

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  SCHEDULE 1 TO EXHIBIT B
  
    BUILDING PLANS AND SPECIFICATIONS
  
    WESTMINSTER
  
    BASE BUILDING CORE AND SHELL    
    

 

			
	Parking Stalls:	 	Parking is provided at 4.1 spaces per 1,000 square feet of rentable building area.
	
 Parking Lot Lighting:	
 	
Parking lot lighting is provided, designed to supply an average to minimum ratio of approximately 1.0 foot candles/SF.
	
 Sitework:	
 	
Asphalt concrete paving in all traffic and parking areas, concrete curb and gutter per approved development plans.
	
 Landscaping:	
 	
Landscape planting materials and irrigation of all planting areas per approved development plans.
	
 Building Structure:	
 	
Precast concrete frame with precast concrete floor and roof structure and approximately 4-inch concrete topping slab.
	
 Floor Loading Criteria:	
 	
Live load is approximately 50 psf in general office area, with approximately 100 psf at corridor and interior office area immediately adjacent to corridor. Partition load is approximately 20 psf.
	
 Ceiling Heights:	
 	
Clear ceiling heights are approximately 12'-2" feet at ground floor tenant areas, and approximately 9'-2" at floors 2, 3, 4 and 5 tenant areas. Typical structure to structure clearance is approximately 14.5 feet at
ground floor 14'-8" from floor to bottom of "T" at ground floor, and 11'-8" approximately 11.5 feet from floor to bottom of "T" at floors 2, 3, 4 and 5. Clearances may be 12 inches less at beam locations.
	
 Building Skin:	
 	
Precast architectural concrete spandrel panels with continuous glazing in between. Full height glazing at most locations. See elevation drawings for detail.
	
 Roofing:	
 	
60 mil EPDM roof membrane, ballasted, over 2.6" rigid polyisocyanruate board. R-value of 19.
	
 Perimeter Walls:	
 	
Perimeter, exterior walls to be insulated only, no drywall.
	
 Core Service Areas:	
 	
1. Sound attenuation is provided to meet NC35 levels.
	 	 	2. Janitor's closet provided on each floor.
	 	 	3. Finished doors provided for all service rooms.
	 	 	4. Door frames to be anodized aluminum for all core doors.
	 	 	 5. One drinking fountain location each floor, with two fountains, one meeting ADA requirements.

	
 Rest Rooms:	
 	
Rest rooms to have ceramic tile on floors, and full height on wet walls. Toilet partitions to be ceiling hung stainless steel. Vanity tops to be granite. Restrooms to be ADA compliant.
	
 Shower Facilities:	
 	
Ground floor restrooms to include two shower stalls each in men's and women's. One shower stall in each to be ADA compliant.

 

 1

 
 

			
	
 Telephone Room:	
 	
Main telephone/fiber optic room provided at ground floor, approximately 20 feet by 10 feet. Conduit to be stubbed into room for telephone and 3 possible fiber optic providers. Approximately 6 foot by 9 foot
communications rooms provided on floors 2, 3, 4 and 5.
	
 Elevators:	
 	
Hydraulic elevators, 3,500 lb. capacity provided. Interior cab height to be approximately 10 feet, with suspended ceiling at approximately 9 feet. Finishes will be compatible with main lobby. Freight elevator to be
supplied with protective blankets. Waiting time will be average of 27-29 seconds, with 5 minute handling capacity of 13% of building population (upper floors only). Elevators to be ADA compliant, and provided with emergency telephones.
	
 Fire Protection:	
 	
Complete fire sprinkler system in accordance with applicable codes for office occupancy. Fireproofing of the Building's structural steel as specified on the structural plans for the Building as approved by the City of
Westminster (a copy of which plans Tenant acknowledges receiving).
	
 Plumbing Systems:	
 	
Complete plumbing system for domestic water service, sanitary sewer service, and roof drainage. Water and sanitary systems will be accessible to tenant areas for future connections for convenience sinks and other
uses.
	
 HVAC:	
 	
HVAC system is provided with rooftop units, total capacity approximately 460 tons, of approximately 350 sf per ton. Primary trunk ducts and exterior zone VAV boxes provided at approximately 1 per 1,100 SF. Exterior
zone VAV boxes are provided with electric reheat. No distribution ducting or diffusers are included at these exterior zone boxes.
	

 	
 	
Energy management system provided, with remote computer monitoring capability. Tenant metering capability also included in system.
	

 	
 	
HVAC Design criteria for cooling load allowed include the following:
	

 	
 	
2 watts per SF for lighting;
	 	 	1.5 watts per SF for office equipment
	 	 	150 SF per person.
	
 Electrical Service:	
 	
The building is provided with primary electrical service, 277/480 volts, 3 phase, with main disconnects in the main electrical room on the first floor. Electrical distribution panel rooms are provided two per floor
adjacent to stairwells.
	

 	
 	
Electrical service will provide total capacity of 27 watts per square foot, generally allocated as follows:
	

 	
 	
15 watts per SF for HVAC loads;
	 	 	3 watts per SF for lighting;
	 	 	6.5 watts per SF for tenant equipment loads;
	 	 	2.5 watts per SF spare power;

 

 2

 
 

			
	 	 	A pad area for a future generator to be included in the building shell.
	
 Fire Alarm:	
 	
Fire alarm panel is provided, including fire alarm devices as required by code in core and common areas.
	
 Security:	
 	
A card access system to be provided at the main entry doors of the building. Elevator card access also to be available based on tenant needs (but at Tenant's sole cost and expense).

 

 3

QuickLinks

Exhibit 10.5.2

THIRD AMENDMENT TO LEASE

R E C I T A L S

A G R E E M E N T

EXHIBIT A OUTLINE OF EXPANSION SPACE

EXHIBIT B

TENANT WORK LETTER

SCHEDULE 1 TO EXHIBIT B BUILDING PLANS AND SPECIFICATIONS WESTMINSTER BASE BUILDING CORE AND SHELLQuickLinks
 -- Click here to rapidly navigate through this document

 Exhibit 10.5.3  

 FIFTH AMENDMENT TO OFFICE LEASE AGREEMENT  

        THIS FIFTH AMENDMENT TO OFFICE LEASE AGREEMENT (this "Amendment"), dated as of June 16, 2008, (the "Effective Date") is entered
into by and between CIRCLE POINT PROPERTIES, LLC, a Delaware limited liability company (the "Landlord") and ALLOS THERAPEUTICS, INC., a Delaware corporation (the "Tenant"). 

 Recitals: 

        A.    Catellus
Development Corporation, a Delaware limited liability company ("CDC") and Tenant entered into that certain Office Lease dated April 23, 2001, as amended
by that certain First Amendment and Commencement Date Memorandum dated as of November 1, 2001, that certain Second Amendment to Lease dated as of November 12, 2002, that certain Amended
and Restated Second Amendment to Lease dated as of December 9, 2002, that certain Third Amendment to Lease dated as of November 23, 2003 and that certain Consent of Landlord to Sublease
and Fourth Amendment to Lease dated as of January 12, 2005 (collectively the "Lease"), pertaining to the premises containing approximately 43,956 rentable square feet ("RSF"), commonly known as
Suite 200, Suite 160 and Storage Space, Suite 170, Suite 180 and Suite 190 located in the office building located at 11080 Circle Point Road, Westminster, Colorado
80020 (collectively, the "Original Premises"). 

        B.    Landlord
has succeeded to all of CDC's right, title, obligations, and interest under the Lease. 

        C.    Capitalized
terms used herein and not otherwise defined herein shall have the meanings given to them in the Lease. 

        D.    Landlord
and Tenant desire to amend the Lease in the manner and form hereinafter set forth. 

        NOW,
THEREFORE, for good and valuable consideration, Landlord and Tenant hereby agree as follows: 

        1.    Reduction of Premises.    As of the Extension Commencement Date, the Original Premises shall be reduced by
approximately 9,420 RSF as more particularly depicted and cross-hatched on Exhibit A attached hereto and incorporated herein by this reference
(the "Vacated Space"). The resulting space shall be Suite 200 and Suite 160 (and storage space) consisting of approximately 34,536 RSF (the "Reduced Premises") and all references in the
Lease to the "Premises" shall mean the Reduced Premises. Tenant agrees to vacate and surrender possession of the Vacated Space and, unless Landlord provides written notice to Tenant to the contrary,
to cause all parties claiming by, through or under Tenant to vacate and surrender possession of the Vacated Space as of the Extension Commencement Date in the condition as required by the Lease and
this Amendment. Landlord and Tenant hereby acknowledge and agree that effective as of the Extension Commencement Date, Tenant renounces all right of possession in and to the Vacated Space. Any
occupancy of the Vacated Space as of the Extension Commencement Date by Landlord or any party claiming by, through or under Landlord shall not be deemed an eviction (constructive or otherwise). As of
the Extension Commencement Date, rights under the Lease solely for the Vacated Space shall be deemed terminated as though they had expired according to their terms, and except as provided herein,
Landlord and Tenant shall be relieved of any and all further obligations thereunder; provided, however, such termination shall not affect Tenant's liability for rental and other obligations accruing
prior to the Extension Commencement Date, including, without limitation, its obligation to pay Tenant's Percentage Share of Operating Expenses and Tenant's Percentage Share of Real Property Taxes
attributable to the period prior to the Extension Commencement Date, at such time as such obligation is finally determined, nor shall the same affect Landlord's liability to Tenant with respect to
Adjustments due to Tenant under the Lease with respect to the Vacated Space. 

        2.    Term.    Provided there is no uncured Event of Default by Tenant as of November 1, 2008 (the "Extension
Commencement Date"), the term of the Lease for the Reduced Premises shall be extended for thirty-nine (39) months to expire at 12:00 midnight on January 31, 2012 (the
"Extension Term") and 

 

shall
be on all of the terms and conditions of the Lease except as specifically provided herein to the contrary. Tenant's renewal hereunder shall be deemed exercise of its option to renew, pursuant to
Section 3.2 of the Lease and, except as otherwise set forth herein, there shall be no further rights on the part of Tenant to extend the term of the Lease as amended by this Amendment. 

        3.    Base Rent.    Subject to Section 10 below, commencing on
the Extension Commencement Date and continuing throughout the Extension Term, Tenant shall pay Base Rent for the Reduced Premises monthly, in advance, in the manner as set forth in the Lease as
follows: 

 

								
	Period

 
	 	Rate Per RSF 	 	Monthly Base Rent 	 
	 11/1/08 - 1/31/09
	 	$	0.00	 	$	0.00	 
	 02/1/09 - 1/31/10:
	 	$	15.00	 	$	43,170.00	 
	 02/1/10 - 1/31/11:
	 	$	15.50	 	$	44,609.00	 
	 02/1/11 - 1/31/12:
	 	$	16.00	 	$	46,048.00	 

 

         4.    Additional Rent.    Subject to Section 10 below,
commencing on the Extension Commencement Date and continuing throughout the Extension Term, Tenant shall pay Tenant's Percentage of Operating Expenses and Tenant's Percentage of Real Estate Taxes in
accordance with the Lease; provided, however, that as of the Extension Commencement Date, Tenant's Percentage Share shall be equal to 22.809% and the RSF of the Building shall be equal to 151,412 RSF. 

        5.    Condition of Premises.    Except as otherwise set forth herein, Landlord shall have no obligation for the
completion or remodeling of the Reduced Premises and Tenant shall accept the Reduced Premises in its "as is" condition and configuration as of the
Extension Commencement Date. Notwithstanding the foregoing, subject to Section 10 below, Landlord agrees, as its only obligation hereunder with
respect to remodeling of the Reduced Premises (other than the Additional Allowance described herein), at its sole cost and expense to the extent of the sum of five and No/100 Dollars ($5.00) per RSF
in the Premises (the "Construction Allowance"), to finish the Reduced Premises with Building Standard (as hereinafter defined) improvements of the scope to be mutually agreed upon and which, shall
then be attached as Exhibit B hereto and incorporated herein (the "Finish Work") in accordance with a mutually agreed upon space plan, which,
upon its completion, shall be attached as Exhibit C hereto and incorporated herein by this reference (the "Space Plan") using a mutually
acceptable contractor. The Construction Allowance may be used by Tenant for costs of the Finish Work including the architectural design, permitting, engineering, construction, signage and project
management thereof, as well as voice and data cabling, security, furniture, moving and restacking. Other than as set forth on the Space Plan, Landlord shall have no obligations for the completion or
remodeling of the Reduced Premises, and
Tenant shall accept the Reduced Premises in their "as is" condition on the Extension Commencement Date. "Building Standard" as used herein shall mean building standard tenant finish items prestocked
or in place in the Premises which Landlord normally provides to tenants (e.g., ceiling grid, paint, sprinklers, HVAC and similar items). Tenant agrees that because Tenant is currently occupying
the Reduced Premises and will continue to occupy the Reduced Premises as of the Extension Term Commencement Date that Landlord (its agents, employees and contractors) shall have the right to enter the
Reduced Premises to allow Landlord to perform certain construction and remodeling work in connection with the construction of the Finish Work. Tenant acknowledges and that because Landlord will
perform the Finish Work in and about the Reduced Premises, that certain interruption and interference with Tenant's business will likely occur. Landlord will use reasonable efforts to attempt to
minimize the interferences with Tenant's business during the construction of the Finish Work. Nevertheless, Tenant waives (a) any and all claims against Landlord based on constructive eviction
and loss of use or business; and (b) any and all claims against Landlord for any interruption and interference with Tenant's business during Landlord's construction activities including
constructive eviction. Landlord or its agent shall supervise the Finish Work, make disbursements required to be made to the contractor, act as a liaison between the contractor and 

2

 

Tenant
and coordinate the relationship between the Finish Work, the Building and the Building's systems. In consideration for Landlord's construction supervision services, Tenant shall pay to Landlord
a construction supervision fee equal to three percent (3%) of the total construction costs of the Finish Work (excluding the construction supervision fee and any other cost items not directly
supervised by Landlord as are more particularly identified on the scope of Finish Work to be attached as Exhibit C hereto). At Tenant's election,
Landlord shall contribute an additional sum not to exceed Three and No/100 Dollars ($3.00) per RSF in the Reduced Premises (the "Additional Allowance") solely toward additional permanent leasehold
improvements for or in the Premises, excluding any costs related to Tenant's furniture or fixtures. The amount of the Additional Allowance actually utilized by Tenant shall be amortized as additional
Base Rent over the initial Term at nine percent (9%) per annum, in the same manner as a loan having equal monthly payments of principal and interest. Tenant's election to use all or a portion of the
Additional Allowance shall be made by written notice to Landlord given no later than upon approval of the Space Plan. If Tenant elects to receive the Additional Allowance, then within ten
(10) days after Landlord's request, Tenant shall execute and return an amendment (in form reasonably acceptable to Tenant) modifying the Base Rent accordingly. If Tenant fails timely:
(i) to make its election regarding utilization of the Additional Allowance; or (ii) to execute and return the required lease amendment, then Landlord shall automatically be released from
its obligation to contribute the Additional Allowance, whereupon Tenant shall promptly pay Landlord the full amount of any out of pocket costs of the Finish Work in excess of the Construction
Allowance in accordance with this Section 5 (i.e., in accordance with the provision below describing the fifty percent (50%) payment
method). If, for any reason, less than all of the Extension Term remains at the time the required lease amendment is executed and returned to Landlord, then Tenant shall, upon demand, promptly pay all
amortization payments (including interest) which would have been payable for the elapsed portion of the Term through the month in which such lease amendment is actually so executed and returned. Any
failure by Tenant to make any payments required under the foregoing provisions within ten (10) days after notice shall constitute an Event of Default under the Lease as amended by this
Amendment. In the event Tenant does not elect or fails to timely elect to utilize the Additional Allowance, all out of pocket costs for performing the Finish Work in excess of the Construction
Allowance shall be paid by Tenant. In the event Tenant timely elects to utilize the Additional
Allowance, all costs for performing the Finish Work in excess of the Construction Allowance and Additional Allowance shall be paid by Tenant. Tenant shall pay to Landlord fifty percent (50%) of the
amount by which the total costs for the Finish Work will exceed the Construction Allowance (and, if applicable the Additional Allowance) prior to Landlord beginning the Finish Work and the remaining
fifty percent (50%) after Landlord completes the Finish Work. The Construction Allowance and the Additional Allowance, if applicable, shall not be disbursed to Tenant in cash, but shall be applied by
Landlord to the payment of the costs of the Finish Work if, and when the cost of the Finish Work is actually incurred and paid by Landlord. Subject to force majeure and items within the control of
Landlord, the Construction Allowance and the Additional Allowance, if applicable, must be used within twelve (12) months following the Extension Commencement Date or shall be deemed forfeited
with no further obligation by Landlord with respect thereto. 

        6.    Renewal Option.    Subject to Section 10 below, if no
uncured Event of Default exists at the time of exercise or at the commencement of the extended term, and Tenant is occupying at least seventy-five percent (75%) of the entire Reduced
Premises at the time of such election, Tenant may renew the Lease, as hereby amended, for one (1) additional period of three (3) years, by delivering written notice of the exercise
thereof to Landlord not earlier than twelve (12) months nor later than nine (9) months before the expiration of the Extension Term. The Base Rent payable for each month during such
extended term shall be the prevailing fair market rental rate (the "Prevailing Market Rental Rate"), at the commencement of such extended term, for renewals of space in the Building or complex, if
applicable, of equivalent quality, size, utility and location, with the length of the extended term and the credit standing of Tenant to be taken into account. Within thirty (30) days after
receipt of 

3

 

Tenant's
notice to renew, Landlord shall deliver to Tenant written notice of the Prevailing Market Rental Rate and shall advise Tenant of the required adjustment to Base Rent, if any, and the other
terms and conditions offered. Tenant shall, within ten (10) days after receipt of Landlord's notice, notify Landlord in writing whether Tenant accepts or rejects Landlord's determination of the
Prevailing Market Rental Rate. If Tenant timely notifies Landlord that Tenant accepts Landlord's determination of the Prevailing Market Rental Rate, then, on or before the commencement date of the
extended Term, Landlord and Tenant shall execute an amendment to this Lease extending the Extension Term on the same terms provided in the Lease as amended by this Amendment, except as follows: 

        (a)   Base
Rent shall be adjusted to the Prevailing Market Rental Rate; and 

        (b)   Tenant
shall have no further renewal option unless expressly granted by Landlord in writing. 

        If
Tenant rejects Landlord's determination of the Prevailing Market Rental Rate, Tenant shall notify Landlord, within ten (10) days after Landlord delivers notice of the
Prevailing Market Rental Rate to Tenant, of the rental rate that Tenant asserts as the prevailing market rental rate applicable hereunder. Each party shall, at their own expense, within ten
(10) days after Landlord receives Tenant's notice of such dispute, designate by written notice to the other party one (1) qualified, unbiased real estate broker of good reputation,
having at least five (5) years' experience in the Highway 36 Corridor Denver metropolitan area real estate submarket. The two (2) brokers so designated shall each submit a determination
of the prevailing fair market rate. Landlord and Tenant shall each require the brokers to make such determination and report it in writing to Landlord and Tenant within twenty (20) days after
such selection, and each party shall use its best efforts to secure such determination within such time period. If the two (2) selected brokers agree as to what is the prevailing fair market
rental rate, such rate shall deemed the Prevailing Market Rental Rate. If the two (2) selected brokers fail to agree as to what is the prevailing fair market rental rate and the disparity
between the two (2) brokers' asserted prevailing fair market rate is ten percent (10%) or less, the average of the two (2) broker's rates shall be deemed the Prevailing Market Rental
Rate. If the disparity between the two (2) brokers' asserted prevailing fair market rate is greater than ten percent (10%) then, the two (2) brokers shall together immediately select a
third similarly qualified broker who shall then (within ten (10) days of the brokers' selection) determine which rate is closest to the prevailing fair market rental rate as determined by the
third (3rd) broker. The third (3rd) broker shall notify Landlord and Tenant of the broker's determination and the rental rate selected shall be the Prevailing Market Rental Rate applicable hereunder. 

        Unless
otherwise agreed to in writing, Landlord shall not be obligated to pay a commission with respect to Tenant's exercise of the Option, and Tenant shall indemnify, defend, and hold
Landlord harmless from and against all costs, expenses, attorneys' fees, and other liability for commissions or other compensation claimed by any broker or agent claiming the same by, through, or
under Tenant. If Tenant rejects Landlord's determination of the Prevailing Market Rental Rate, or fails to timely notify Landlord in writing that Tenant accepts or rejects Landlord's determination of
the Prevailing Market Rental Rate, time being of the essence with respect thereto, Tenant's rights under this Section 6 shall terminate and
Tenant shall have no right to renew this Lease. Tenant's rights under this Section 6 shall terminate if (1) the Lease as amended by this
Amendment or Tenant's right to possession of the Reduced Premises is terminated, (2) Tenant assigns any of its interest in the Lease as amended by this Amendment except to an Affiliated
Assignee or sublets any portion of the Reduced Premises except to an Affiliate, (3) Tenant fails to timely exercise its option under this  Section 6, time being of the essence with respect to
Tenant's exercise thereof, or (4) Landlord determines, in its reasonable judgment,
that Tenant will be unable to meet its financial obligations under the Lease as extended due to Tenant's financial condition or creditworthiness. 

4

 

        7.    Expansion Option.    During the Extension Term, Tenant shall have the Right of First Offer as set forth in
Section 2.5 of the Lease. 

        8.    Parking.    As of the Extension Commencement Date, Tenant shall have the right to One Hundred
Forty-Five (145) parking spaces in accordance with the terms of the Lease. 

        9.    Notices.    Wherever any notice is required or permitted under the Lease as amended by this Amendment such
notice shall be in writing and delivered in accordance with the terms of the Lease; provided, however that Landlord's address for notices shall be as follows: 

Landlord: 

Cushman &
Wakefield

11080 Circle Point Road

Westminster, Colorado 80020

Attn: Cushman & Wakefield 

With
a copy to: 

Circle
Point Properties, LLC

c/o Northridge Capital, LLC

1000 Potomac Street NW, Suite 150

Washington, DC 20007

Attn.: Kevin Fay 

Tenant:

AT
THE PREMISES 

With
a copy to:

Attn: General Counsel 

        10.    Condition Subsequent.    This Amendment is expressly subject to the following condition subsequent, that as of
the Extension Commencement Date there exist no uncured Events of Default. If such uncured Event of Default does exist as of the Extension Commencement Date then, at Landlord's election, Landlord may
declare this Amendment null and void ab initio, and thereafter: (i) Tenant's right to exercise the Option to Extend pursuant to
Section 3.2 of the Lease shall be forfeited and there shall be no further rights on the part of Tenant to extend the term of the Lease under the original Lease or as amended by this Amendment;
and (ii) the Lease shall be deemed to have terminated at the end of
the original Lease Term and thereafter Tenant shall surrender possession of the Premises in the manner required under the Lease. 

        11.    Mold and Moisture.    It is generally understood that mold spores are present essentially everywhere and that
mold can grow in most any moist location. Emphasis is properly placed on prevention of moisture and on good housekeeping and ventilation practices. Tenant acknowledges the necessity of housekeeping,
ventilation, and moisture control (especially in kitchens, janitor's closets, bathrooms, break rooms and around outside walls) for mold prevention. In signing this Amendment, Tenant has not observed
mold, mildew or moisture within the Reduced Premises; however, Tenant has not hired any inspector to confirm/deny such claim, nor has Tenant investigated behind any of the walls in the Reduced
Premises or the Building. Tenant agrees to promptly notify Landlord if Tenant observes mold/mildew and/or moisture conditions (from any source, including leaks), and allow Landlord to evaluate and
make recommendations and/or take appropriate corrective action at Landlord's cost unless otherwise set forth in the Lease. Tenant releases Landlord from any liability for any personal injury or
damages to property caused by or associated with moisture or the growth of or occurrence of mold or mildew on the Reduced Premises or the Building of which Tenant knew and failed to notify Landlord in
accordance with this Section 11. In addition, execution of this Amendment constitutes 

5

 

acknowledgement
by Tenant that control of moisture and mold prevention are integral to its obligations under the Lease as modified by this Amendment; provided, however, that Landlord, at its sole cost
and expense, shall be responsible for remediation of any mold or mildew in the Building, for fixing leaks in the Building, for providing proper ventilation to the Building to prevent moisture
accumulation, and for causing its cleaning service provider to diligently mop up or otherwise remove any mold, mildew or moisture that such provider encounters in its daily cleaning of the Reduced
Premises. 

        12.    Brokers.    Tenant and Landlord hereby warrant and represent each to the other that neither has engaged any
brokers or agents in the transaction which resulted in this Amendment other than CB Richard Ellis, Inc., ("Landlord's Broker") and Jones Lang LaSalle ("Tenant's Broker"), which shall be paid a
commission by Landlord pursuant to a separate agreement. Each party shall indemnify the other against any expense incurred as a result of any claim for brokerage or other commissions made by any other
broker, finder, or agent, whether or not meritorious, employed by the other party or claiming by, through, or under Tenant or Landlord respectively. 

        13.    Interpretation.    If there is any conflict between the terms of this Amendment and the terms of the Lease, the
terms of this Amendment shall govern. Except as herein specifically set forth, all other provisions of the Lease shall remain in full force and effect and be binding upon the parties in accordance
with their terms. The Lease as hereby amended is in full force and effect, is hereby ratified and affirmed by the parties, and is binding upon the parties in accordance with its terms. 

        14.    Time of Essence.    Time is of the essence herein and, unless waived by Landlord (which it shall have the
right, but not the obligation, to do so) this Amendment is contingent upon execution and delivery by Tenant to Landlord no later than 5:00 p.m., May 15,
2008. 

        15.    Counterparts.    This Amendment may be executed in one or more separate counterparts but each separate
counterpart, when assembled with the other signature pages from the corresponding counterpart signature pages, shall constitute one original executed Amendment. 

[Remainder
of Page Intentionally Left Blank] 

6

 

        IN
WITNESS WHEREOF, the parties have executed this Amendment as of the day and year first above written and is effective upon delivery of a fully executed copy to Tenant. 

											
	 	 	 LANDLORD:
	

 	
 	
CIRCLE POINT PROPERTIES, LLC,

a Delaware limited liability company
	

 	
 	
By:	
 	
Circle Point Properties II, LLC

a Delaware limited liability company

its: Sole Member
	

 	
 	
 	
 	
By:	
 	
Circle Point Holdings, LLC

a Delaware limited liability company

its: Sole Member
	

 	
 	
 	
 	
 	
 	
By:	
 	
NORTHRIDGE CAPITAL, LLC,

a Delaware limited liability

company, its Managing Member
	

 	
 	
 	
 	
 	
 	
 	
 	
By:	
 	
/s/ Kevin J. Fay

 
	 	 	 	 	 	 	 	 	Name:	 	Kevin J. Fay

 
	 	 	 	 	 	 	 	 	Title:	 	Vice President

 
	

 	
 	
 TENANT:
	

 	
 	
ALLOS THERAPEUTICS, INC.,

a Delaware corporation
	

 	
 	
By:	
 	
/s/ Marc Graboyes

 
	 	 	Name:	 	Marc Graboyes

 
	 	 	Title:	 	SVP, General Counsel

 
	

 	
 	
ATTEST:
	

 	
 	
By:	
 	
/s/ David C. Clark

 
	 	 	Name:	 	David C. Clark

 
	 	 	Title:	 	VP Finance

 

7

 
 EXHIBIT A  

 
    (The Vacated Space)    
    

8

 

  

9

 

 
 

  EXHIBIT B    
    
    (Scope of the Finish Work)    
    

[to
be attached] 

10

 

  

11

 
 
 

  EXHIBIT C    
    
    (The Space Plan)    
    

[to
be attached] 

12

 

  

13

QuickLinks

(The Vacated Space)

EXHIBIT B (Scope of the Finish Work)

EXHIBIT C (The Space Plan)

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