Document:

Exhibit
      4.1

     

    THIS
      CLASS D WARRANT AND THE SHARES OF COMMON STOCK ISSUABLE UPON EXERCISE HEREOF
      HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED
      (“SECURITIES ACT”) OR ANY STATE SECURITIES LAWS AND MAY NOT BE SOLD, TRANSFERRED
      OR OTHERWISE DISPOSED OF UNLESS REGISTERED UNDER THE SECURITIES ACT AND UNDER
      APPLICABLE STATE SECURITIES LAWS OR CYTOMEDIX, INC. SHALL HAVE RECEIVED AN
      OPINION OF COUNSEL REASONABLY SATISFACTORY TO CYTOMEDIX, INC. THAT REGISTRATION
      OF SUCH SECURITIES UNDER THE SECURITIES ACT AND UNDER THE PROVISIONS OF
      APPLICABLE STATE SECURITIES LAWS IS NOT REQUIRED.

    

    CLASS
      D WARRANT TO PURCHASE

    SHARES
      OF COMMON STOCK

    OF

    CYTOMEDIX,
      INC.

    

    Expires
      April 12, 2011

    
 

    
      	No.:
              W-D-06-______________	
              Number
                of Shares:
                ___________

            

    

    Date
      of Issuance: April 12, 2006

    

    THIS
      IS
      TO CERTIFY THAT, for value received, ______________________, or its assigns,
      (“Holder”), is entitled to purchase from Cytomedix, Inc., a Delaware corporation
      (“Company”), ______________________ (__________________) shares of the Company’s
      common stock, par value $.0001 per share (“Common Stock”), on the terms and
      conditions hereinafter set forth.

    

    I. Grant
      of Warrant

    

    1.1 Grant
      and Vesting.
      The
      Company hereby grants to the Holder Class D Warrants (“Warrants”) to purchase up
      to ________________ (______) shares of Common Stock at a purchase price equal
      to
      $3.50 per share of Common Stock (“Exercise Price”). The Warrants shall vest as
      to all shares of Common Stock immediately. The shares of Common Stock for which
      the Warrants may be exercised are referred to as the “Warrant Shares.”

    

    1.2 Exercise
      Period.
      The
      Warrants shall be exercisable commencing on the date of original issuance of
      the
      Warrants (“Exercisability Date”) and continue to be exercisable for the period
      (“Exercise Period”) until 5:00 p.m., eastern time, on April 12, 2011, from the
      date of issuance of the Warrants.

    

    1.3 Shares
      To Be Issued; Reservation of Shares.
      The
      Company covenants and agrees that (a) all of the securities issuable upon the
      exercise of the Warrants in accordance with the terms hereof will, upon issuance
      in accordance with the terms hereof and payment of the Exercise Price therefor,
      be duly authorized, validly issued and outstanding, fully paid and
      non-assessable, and free from all taxes, liens and charges with respect to
      the
      issuance thereof and (b) the Company will cause during the Exercise Period,
      there to be authorized and reserved a sufficient number of securities to provide
      for the exercise of the Warrants in full.

    

    
      
         

      

      
         

        
          

        

      

      
         

      

    

     

    II. Adjustments
      to Warrants

    

    2.1 Stock
      Splits and Combinations.
      If the
      Company shall combine all of its outstanding shares of Common Stock into a
      smaller number of shares, the number of Warrant Shares shall be proportionately
      decreased and the Exercise Price in effect immediately prior to such combination
      shall be proportionately increased, as of the effective date of such
      combination, as follows: (a) the number of Warrant Shares purchasable
      immediately prior to the effective date of such combination shall be adjusted
      so
      that the Holder of the Warrants, if exercised on or after that date, shall
      be
      entitled to receive the number and kind of Warrant Shares which the Holder
      of
      the Warrants would have owned and been entitled to receive as a result of the
      combination had the Warrants been exercised immediately prior to that date,
      and
      (b) the Exercise Price in effect immediately prior to such adjustment shall
      be
      adjusted by multiplying such Exercise Price by a fraction, the numerator of
      which is the aggregate number of shares of Common Stock purchasable upon
      exercise of the Warrants immediately prior to such adjustment, and the
      denominator of which is the aggregate number of shares of Common Stock
      purchasable upon exercise of this Warrants immediately thereafter. If the
      Company shall subdivide all of its outstanding shares of Common Stock, the
      number of Warrant Shares shall be proportionally increased and the Exercise
      Price in effect prior to such subdivision shall be proportionately decreased,
      as
      of the effective date of such subdivision, as follows: (a) the number of Warrant
      Shares purchasable upon the exercise of the Warrants immediately prior to the
      effective date of such subdivision, shall be adjusted so that the Holder of
      the
      Warrants, if exercised on or after that date, shall be entitled to receive
      the
      number and kind of Warrant Shares which the Holder of the Warrants would have
      owned and been entitled to receive as a result of the subdivision had the
      Warrants been exercised immediately prior to that date, and (b) the Exercise
      Price in effect immediately prior to such adjustment shall be adjusted by
      multiplying the Exercise Price by a fraction, the numerator of which is the
      aggregate number of shares of Common Stock purchasable upon exercise of the
      Warrants immediately prior to such adjustment, and the denominator of which
      is
      the aggregate number of shares of Common Stock purchasable upon exercise of
      the
      Warrants immediately thereafter.

    

    2.2 Stock
      Dividends and Distributions.
      If the
      Company shall fix a record date for the holders of its Common Stock entitled
      to
      receive a dividend or other distribution payable in additional shares of Common
      Stock, then the number of Warrant Shares shall be proportionately increased
      and
      the Exercise Price in effect prior to the time of such issuance or the close
      of
      business on such record date shall be proportionately decreased, as of the
      time
      of such issuance, or in the event such record date is fixed, as of the close
      of
      business on such record date, as follows: (a) the number of Warrant Shares
      purchasable immediately prior to the time of such issuance or the close of
      business on such record date shall be adjusted so that the Holder of the
      Warrants, if exercised after that date, shall be entitled to receive the number
      and kind of Warrant Shares which the Holder of the Warrants would have owned
      and
      been entitled to receive as a result of the dividend or distribution had the
      Warrants been exercised immediately prior to that date, and (b) the Exercise
      Price in effect immediately prior to such adjustment shall be adjusted by
      multiplying such Exercise Price by a fraction, the numerator of which is the
      aggregate number of shares of Common Stock purchasable upon exercise of the
      Warrants immediately prior to such adjustment, and the denominator of which
      is
      the aggregate number of shares of Common Stock purchasable upon exercise of
      the
      Warrants immediately thereafter.

    

    
      
         

      

      
         

        
          

        

      

      
         

      

       

    

    2.3 Other
      Dividends and Distributions.
      If the
      Company shall fix a record date for the holders of Common Stock entitled to
      receive a dividend or other distribution payable in securities of the Company
      other than shares of Common Stock, then lawful and adequate provision shall
      be
      made so that the Holder of the Warrants shall be entitled to receive upon
      exercise of the Warrants, for the applicable exercise price in effect prior
      thereto, in addition to the number of Warrant Shares immediately theretofore
      issuable upon exercise of the Warrants, the kind and number of securities of
      the
      Company which the Holder would have owned and been entitled to receive had
      the
      Warrants been exercised immediately prior to that date.

    

    2.4 Reclassification,
      Exchange and Substitution.
      If
      the
      Common Stock is changed into the same or a different number of shares of any
      class or classes of stock, whether by recapitalization, reclassification or
      otherwise (other than by a subdivision or combination of shares or stock
      dividend or a reorganization, merger, consolidation or sale of assets provided
      for elsewhere in this Article II), then the Holder of the Warrants shall be
      entitled to receive upon exercise of the Warrants, in lieu of the Warrant Shares
      immediately theretofore issuable upon exercise of the Warrants, for the
      aggregate exercise price in effect prior thereto, the kind and amount of stock
      and other securities and property receivable upon such recapitalization,
      reclassification or other change, by the holders of the number of shares of
      Common Stock for which the Warrants could have been exercised immediately prior
      to such recapitalization, reclassification or other change (in any event,
      subject to further anti-dilution protection as provided in this Article
      II).

    

    2.5 Reorganizations,
      Mergers. Consolidations or Sales of Assets.
      If any
      of the following transactions (each, a “Special Transaction”) shall become
      effective: (a) a capital reorganization, share exchange or exchange offer (other
      than a recapitalization, subdivision, combination, reclassification or exchange
      of shares provided for elsewhere in this Article II), (b) a consolidation or
      merger of the Company with and into another entity, or (c) a sale or conveyance
      of all or substantially all of the Company’s assets, then as a condition of any
      Special Transaction, lawful and adequate provision shall be made so that the
      Holder of the Warrants shall thereafter have the right to purchase and receive
      upon exercise of the Warrants, in lieu of the Warrant Shares immediately
      theretofore issuable upon exercise of the Warrants, for the applicable exercise
      price in effect immediately prior to such event, such shares of stock, other
      securities, cash or other assets as may be issued or payable in and pursuant
      to
      the terms of such Special Transaction to the holders of shares for which the
      Warrants could have been exercised immediately prior to such Special
      Transaction. In connection with any Special Transaction, appropriate provision
      shall be made with respect to the rights and interests of the Holder of the
      Warrants to the end that the provisions of the Warrants (including, without
      limitation, provisions for adjustment of the applicable exercise price and
      the
      number of Warrant Shares issuable upon the exercise of this Warrant), shall
      thereafter be applicable, as nearly as may be practicable, to any shares of
      stock, other securities, cash or other assets thereafter deliverable upon the
      exercise of the Warrants. The Company shall not effect any Special Transaction
      unless prior to, or simultaneously with, the closing thereof; the successor
      entity and the issuer of the securities into which the Warrants are exercisable
      (if other than the Company), resulting from such Special Transaction, shall
      assume by a written instrument executed and mailed by certified mail or
      delivered to the Holder of the Warrants at the address of the Holder appearing
      on the books of the Company, the obligation of the Company or such successor
      corporation to deliver to the Holder such shares of stock, securities, cash
      or
      other assets, as in accordance with the foregoing provisions, which the Holder
      shall have the right to purchase.

    

    
      
         

      

      
         

        
          

        

      

      
         

      

       

    

    2.6 Notice.
      Whenever
      the Warrants or the number of Warrant Shares are to be adjusted as provided
      herein, the Company shall forthwith, as soon as reasonably practicable, cause
      to
      be sent to the Holder a notice stating in reasonable detail the relevant facts
      and any resulting adjustments and the calculation thereof.

    

    2.7 Fractional
      Interests.
      The
      Company shall not be required to issue fractions of shares of Common Stock
      upon
      the exercise of the Warrants. If any fraction of a share of Common Stock would
      be issuable upon the exercise of the Warrants, the Company shall, upon such
      issuance, purchase such fraction for an amount in cash equal to the current
      value of such fraction, computed on the basis of the last reported closing
      price
      of the Common Stock on the securities exchange or quotation system on which
      the
      shares of Common Stock are then listed or traded, as the case may be, if any,
      on
      the last business day prior to the date of exercise upon which such a sale
      shall
      have been effected, or, if the Common Stock is not so listed or traded on an
      exchange or quotation system, as the Board of Directors of the Company may
      in
      good faith determine.

    

    2.8 Effect
      of Alternate Securities.
      If at
      any time, as a result of an adjustment made pursuant to this Article II, the
      Holder of the Warrants shall thereafter become entitled to receive any
      securities of the Company other than shares of Common Stock, then the number
      of
      such other securities receivable upon exercise of the Warrants shall be subject
      to adjustment from time to time on terms as nearly equivalent as practicable
      to
      the provisions with respect to shares of Common Stock contained in this Article
      II.

    

    
      
         

      

      
         

        
          

        

      

      
         

      

    

    

    2.9 Successive
      Application.
      The
      provisions of this Article II shall apply from time to time to successive events
      covered by this Article II. Upon the occurrence of any event contemplated by
      this Article II, all references to Common Stock, to the Company and to other
      defined terms shall be equitably adjusted to protect the interests of the
      Holder.

    

    2.10 Other
      Notices.
      In case
      at any time:

    

    (i) the
      Company shall declare any dividend upon the Common Stock payable in shares
      of
      stock of any class or make any other distribution (including dividends or
      distributions payable in cash out of retained earnings) to the holders of the
      Common Stock;

    

    (ii) the
      Company shall offer for subscription pro rata to the holders of the Common
      Stock
      any additional shares of stock of any class or other rights;

    

    (iii) there
      shall be any capital reorganization of the Company, or reclassification of
      the
      Common Stock, or consolidation or merger of the Company with or into, or sale
      of
      all or substantially all its assets to, another corporation or entity;
      or

    

    (iv) there
      shall be a voluntary or involuntary dissolution, liquidation or winding-up
      of
      the Company.

    

    Then,
      in
      each such case, the Company shall give to the Holder of the Warrants (a) notice
      of the date on which the books of the Company shall close or a record shall
      be
      taken for determining the holders of Common Stock entitled to receive any such
      dividend, distribution, or subscription rights or for determining the holders
      of
      Common Stock entitled to vote in respect of any such reorganization,
      reclassification, consolidation, merger, sale, dissolution, liquidation or
      winding-up and (b) in the case of any such reorganization, reclassification,
      consolidation, merger, sale, dissolution, liquidation or winding-up, notice
      of
      the date (or, if not then known, a reasonable approximation thereof by the
      Company) when the same shall take place. Such notice shall also specify the
      date
      on which the holders of Common Stock shall be entitled to receive such dividend,
      distribution, or subscription rights or to exchange their Common Stock for
      stock
      or other securities or property deliverable upon such reorganization,
      reclassification, consolidation, merger, sale, dissolution, liquidation, or
      winding-up, as the case may be. Such notice shall be given at least twenty
      (20)
      business days prior to the record date or the date on which the Company’s books
      are closed in respect thereto. Failure to give any such notice or any defect
      therein shall not affect the validity of the proceedings referred to in clauses
      (i), (ii), (iii) and (iv) above.

    

    2.11 Adjustments
      to Exercise Price.
      Notwithstanding
      anything herein, no adjustment to the Exercise Price shall be made with respect
      to the issuance of securities by the Company.

    

    
      
         

      

      
         

        
          

        

      

      
         

      

    

    

    III. Exercise

    

    3.1 Exercise
      of Warrants.

    

    (a) The
      Holder may exercise the Warrants by (i) surrendering this Warrant with the
      form
      of exercise notice attached hereto duly executed by the Holder, and (ii) making
      payment to the Company of the aggregate Exercise Price for the applicable
      Warrant Shares in cash, by certified check or wire transfer of immediately
      available funds to an account designated by the Company. Upon any partial
      exercise of this Warrant, the Company, at its expense, shall promptly issue
      to
      the Holder for its surrendered Warrant a replacement Warrant identical in all
      respects to this Warrant, except that the number of Warrant Shares shall be
      reduced accordingly.

    

    (b) Notwithstanding
      anything in this Warrant to the contrary, in no event shall the Holder of the
      Warrants be entitled to exercise the Warrants (or portions thereof) if the
      sum
      of (i) the number of shares of Common Stock beneficially owned by the holder
      and
      its affiliates (other than shares of Common Stock which may be deemed
      beneficially owned through the ownership of the unexercised Warrants and the
      unexercised or unconverted portion of any other securities of the Company),
      and
      (ii) the number of shares of Common Stock issuable upon exercise of the Warrants
      (or portions thereof) with respect to which the determination described herein
      is being made, would at the time of exercise result in beneficial ownership
      by
      the Holder and its affiliates of more than 9.9% of the outstanding shares of
      Common Stock. For purposes of the immediately preceding sentence, beneficial
      ownership shall be determined in accordance with Section 13(d) of the Securities
      Exchange Act of 1934, as amended, and Regulation 13D-G thereunder.

    

    (c) Each
      person in whose name any Warrant Share certificate is issued upon exercise
      of
      the Warrants shall for all purposes been deemed to have become the holder of
      record of the Warrant Shares for which the Warrants were exercised as of the
      date of exercise. Certificates for the Warrant Shares so purchased, representing
      the aggregate number of shares specified in the Exercise Agreement, shall be
      delivered to the holder hereof within a reasonable time after the Warrants
      shall
      have been so exercised. The certificates so delivered shall be in such
      denominations as may be requested by the holder hereof and shall be registered
      in the name of such holder or such other name as shall be designated by such
      holder. If the Warrants shall have been exercised only in part, then, unless
      the
      Warrants have expired, the Company shall, at its expense, at the time of
      delivery of such certificates, deliver to the holder a new Warrant representing
      the number of Warrants which have not been exercised.

    

    3.2 Issuance
      of Warrant Shares.
      The
      Warrant Shares purchased shall be issued to the Holder exercising the Warrants
      as of the close of business on the business day on which all actions and
      payments required to be taken or made by the Holder hereunder shall have been
      so
      taken or made. Certificates for the Warrant Shares so purchased shall be
      delivered to the Holder as soon as reasonably practicable after the Warrants
      are
      so exercised.

    

    
      
         

      

      
         

        
          

        

      

      
         

      

       

    

    IV. Call

    

    Commencing
      upon the effective date of a registration statement under the Securities Act,
      providing for the resale of the Warrant Shares (“Registration Statement”), the
      Company may call up to one hundred percent (100%) of this Warrant if the last
      reported closing price of the Common Stock on the securities exchange of
      quotation system on which the Common Stock is then listed or traded has been
      greater than $4.50 (as may be adjusted for any stock splits or combinations
      of
      the Common Stock) for a period of at least ten (10) consecutive trading days
      prior to the date of delivery of the Call Notice (a “Call Notice Period”) by
      providing the Holder of this Warrant written notice pursuant to Section 9.11
      (the “Call Notice”); provided,
      that
      (a) the
      Registration Statement is then in effect, (b) trading in the Common Stock shall
      not have been suspended by the Securities and Exchange commission or the
      securities exchange or quotation system on which the Common Stock is then listed
      or traded. The rights and privileges granted pursuant to this Warrant with
      respect to the shares of Warrant Stock subject to the Call Notice (the “Called
      Warrant Shares”) shall expire on the twentieth (20th)
      day
      after the Holder receives the Call Notice (the “Early Termination Date”). If
      this Warrant is not exercised with respect to such Called Warrant Shares, the
      Issuer shall remit to the Holder of this Warrant (a) $.01 per Called Warrant
      Share and (b) a new Warrant representing the number of shares of Warrant Stock,
      if any, which shall not have been subject to the call Notice upon the Holder
      tendering to the Issuer the applicable Warrant certificate. The Call Notice
      shall be deemed received by the Holder on the date actually received, but not
      later than three (3) business days after the Call Notice was properly posted
      or
      given to such express delivery service in accordance with Section 9.11. If
      made
      by telex, telecopy or other facsimile transmission in accordance with Section
      9.11, the Call Notice shall be deemed to have been made and received at the
      time
      of dispatch.

    

    V. Rights
      of the Holder

    

    5.1 No
      Rights or Liabilities as Shareholder.
      Except
      as provided herein, the Holder shall not, solely by virtue of the Warrants
      and
      prior to the issuance of the Warrant Shares upon due exercise hereof, be
      entitled to any rights as a shareholder of the Company. No provision of this
      Warrant, in the absence of affirmative action by the Holder hereof to purchase
      Warrant Shares, and no mere enumeration herein of the rights or privileges
      of
      the Holder hereof, shall give rise to any liability of such Holder for the
      Exercise Price or as a shareholder of the Company, whether such liability is
      asserted by the Company or by creditors of the Company.

    

    5.2 Certain
      Covenants.
      The
      Company will (a) take all such action as may be necessary or appropriate in
      order that the Warrant Shares will, upon issuance in accordance with the terms
      hereof and the payment of the Exercise Price therefor, be duly authorized,
      validly issued and outstanding, fully paid and non-assessable and (b) use its
      reasonable efforts to obtain all such authorizations, exemptions or consents
      from any public regulatory body having jurisdiction thereof as may be necessary
      to enable the Company to perform its obligations under this Warrant. The Company
      will not, by amendment of its charter or through any reorganization, transfer
      of
      assets, consolidation, merger, dissolution, issue or sale of securities, or
      any
      other voluntary action, avoid or seek to avoid the observance or performance
      of
      any of the terms to be observed or performed by it hereunder, but will at all
      times in good faith assist in the carrying out of all the provisions of this
      Warrant and in the taking of all such action as may reasonably be requested
      by
      the Holder of this Warrant in order to protect the exercise privilege of the
      Holder of the Warrants against dilution or other impairment, consistent with
      the
      tenor and purpose of this Warrant. Without limiting the generality of the
      foregoing, the Company (i) will not increase the par value of any shares of
      Common Stock receivable upon the exercise of the Warrants above the Exercise
      Price then in effect, and (ii) will take all such actions as may be necessary
      or
      appropriate in order that the Company may validly and legally issue fully paid
      and nonassessable shares of Common Stock upon the exercise of the Warrants
      in
      accordance with the terms hereof and payment of the Exercise Price
      therefor.

    

    
      
         

      

      
         

        
          

        

      

      
         

      

    

    
      
         

        VI.
          Loss

      

    

    

    Upon
      receipt by the Company of evidence reasonably satisfactory to it of the loss,
      theft, destruction or mutilation of this Warrant, and (in the case of loss,
      theft or destruction) reasonably satisfactory indemnification, and upon
      surrender and cancellation of the Warrant, if mutilated, the Company shall
      immediately execute and deliver a new Warrant of like tenor and
      date.

    

    VII. Legend
      On Warrant Shares

    

    7.1 Legend.
      The
      certificates representing the Warrant Shares shall bear a legend substantially
      similar to the following:

    

    THE
      SECURITIES OFFERED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT
      OF
      1933 OR THE SECURITIES LAWS OF ANY STATE AND ARE BEING OFFERED AND SOLD IN
      RELIANCE ON EXEMPTIONS FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES
      ACT
      OF 1933 AND SUCH LAWS. THE SECURITIES ARE SUBJECT TO RESTRICTIONS ON
      TRANSFERABILITY AND RESALE AND MAY NOT BE TRANSFERRED OR RESOLD EXCEPT AS
      PERMITTED UNDER THE SECURITIES ACT OF 1933 AND SUCH LAWS PURSUANT TO
      REGISTRATION OR EXEMPTION THEREFROM. 

    

    VIII. Registration
      Rights

    

    The
      Holder shall be entitled to registration rights pursuant to the terms of that
      certain Registration Rights Agreement between the Company and the signatories
      thereto (the “Registration Rights Agreement”) of even date
      herewith.

    

    IX. Miscellaneous

    

    
      
         

      

      
         

        
          

        

      

      
         

      

       

    

    9.1 Representations
      of the Company.
      The
      Company represents and warrants to the Holder as follows:

    

    (a) The
      execution and delivery of the Warrants and the performance by the Company of
      its
      obligations hereunder have been duly authorized by all necessary corporate
      action on part of the Company in accordance with its corporate organizational
      documents.

    

    (b) This
      Warrant has been duly executed and delivered by the Company and constitutes
      the
      legal, valid, binding and enforceable obligation of the Company, enforceable
      in
      accordance with its terms, except as such enforceability may be limited by
      applicable bankruptcy, insolvency, reorganization, moratorium, liquidation
      or
      similar laws relating to, or affecting generally, the enforcement of creditors’
rights and remedies or by other equitable principles of general
      application.

    

    (c) Upon
      issuance thereof in accordance with the terms hereof and payment of the Exercise
      Price therefor, all of the Warrant Shares will, upon issuance, be duly
      authorized, validly issued and outstanding, fully paid and non-assessable,
      and
      free from all taxes, liens and charges with respect to the issuance
      thereof.

    

    (d) Except
      for filings under applicable state and federal securities laws, the Company
      has
      obtained all such authorizations, exemptions or consents from any public
      regulatory body having jurisdiction thereof as may be necessary to enable the
      Company to perform its obligations hereunder.

    

    9.2 Assignment.
      The
      rights, obligations and duties of the Company hereunder shall not be assignable
      or otherwise transferable by the Company. The Warrants and the rights granted
      to
      the Holder hereof are transferable by the Holder, in whole or in part, upon
      surrender of this Warrant, together with a properly executed assignment in
      the
      form attached hereto, at the office or agency of the Company.

    

    If,
      at
      the time of the surrender of this Warrant in connection with any exercise,
      transfer, or exchange of the Warrants, the Warrants (or, in the case of any
      exercise, the Warrant Shares issuable hereunder), are not registered under
      the
      Securities Act and under applicable state securities or blue sky laws, the
      Company may require, as a condition of allowing such exercise, transfer, or
      exchange, (i) that the Holder or transferee of this Warrant, as the case may
      be,
      furnish to the Company a written opinion of counsel, which opinion and counsel
      are acceptable to the Company, to the effect that such exercise, transfer,
      or
      exchange may be made without registration under said Act and under applicable
      state securities or blue sky laws, (ii) that the holder or transferee execute
      and deliver to the Company an investment letter in form and substance acceptable
      to the Company and (iii) that the transferee be an “accredited investor” as
      defined in Rule 501(a) of Regulation D promulgated under the Securities Act;
      provided that no such opinion, letter or status as an “accredited investor”
shall be required in connection with a transfer pursuant to Rule 144 under
      the
      Securities Act. The first Holder of the Warrants, by taking and holding the
      same, represents to the Company that such Holder is acquiring the Warrants
      for
      investment and not with a view to the distribution thereof.

    

    
      
         

      

      
         

        
          

        

      

      
         

      

       

    

    9.3 Modification.
      No term
      or provision contained herein may be modified, amended or waived except by
      written agreement or consent signed by the party to be bound
      thereby.

    

    9.4 Binding
      Effect and Benefit.
      The
      Warrants shall inure to the benefit of, and shall be binding upon, the parties
      hereto, their heirs, executors, administrators, personal representatives,
      successors in interest and permitted assigns.

    

    9.5 Further
      Assurances.
      Company
      agrees that from time to time hereafter, upon request, it will, at its sole
      expense, execute, acknowledge and deliver such other instruments and documents
      and take such further action as may be reasonably necessary to carry out the
      intent of the Warrants.

    

    9.6 Governing
      Law: Waiver of Jury Trial.
      THIS
      WARRANT SHALL BE INTERPRETED, AND THE RIGHTS AND LIABILITIES OF THE PARTIES
      HERETO DETERMINED, IN ACCORDANCE WITH THE INTERNAL LAWS (AS OPPOSED TO CONFLICTS
      OF LAW PROVISIONS) OF THE STATE OF DELAWARE. AS PART OF THE CONSIDERATION FOR
      NEW VALUE THIS DAY RECEIVED, THE COMPANY, AND THROUGH ITS RECEIPT OF THIS
      WARRANT THE HOLDER, HEREBY CONSENT TO THE EXCLUSIVE JURISDICTION OF ANY STATE
      OR
      FEDERAL COURT LOCATED IN MONTGOMERY COUNTY, MARYLAND. EACH OF THE COMPANY AND
      THE HOLDER HEREBY IRREVOCABLY AND UNCONDITIONALLY WAIVES TRIAL BY JURY IN ANY
      SUIT OR PROCEEDING ARISING OUT OF OR RELATED TO THE WARRANTS. THE COMPANY WAIVES
      ANY OBJECTION WHICH THE COMPANY MAY HAVE BASED ON LACK OF JURISDICTION OR
      IMPROPER VENUE OR FORUM
      NON CONVENIENS
      TO ANY
      SUIT OR PROCEEDING INSTITUTED BY THE HOLDER UNDER THE WARRANTS IN ANY STATE
      OR
      FEDERAL COURT LOCATED IN MONTGOMERY COUNTY, MARYLAND AND CONSENTS TO THE
      GRANTING OF SUCH LEGAL OR EQUITABLE RELIEF AS IS DEEMED APPROPRIATE BY THE
      COURT.

    

    9.7 Incorporation
      by Reference.
      All
      exhibits and documents
      referred to in this Warrant shall be deemed incorporated herein by any reference
      thereto as if fully set out.

    

    9.8 Counterparts.
      This
      Warrant may be executed in one or more counterparts (all counterparts together
      reflecting the signature of all parties) each of which shall be deemed an
      original, and all of which together shall constitute one and the same
      instrument.

    

    9.9 Survival
      of Agreements.
      All
      agreements, covenants, representations and warranties contained herein or made
      in writing by or on behalf of the Company in connection with the transactions
      contemplated hereby shall survive the execution and delivery of this
      Warrant.

    

    
      
         

      

      
         

        
          

        

      

      
         

      

       

    

    9.10 Headings
      and Captions.
      Subject
      headings and captions are included for convenience purposes only and shall
      not
      affect the interpretation of this Warrant.

    

    9.11 Notice.
      All
      notices, requests, demands and other communications permitted or required
      hereunder shall be in writing, and either (i) delivered in person, (ii) sent
      by
      express mail or other overnight delivery service providing receipt of delivery,
      (iii) mailed by certified or registered mail, postage prepaid, return receipt
      requested or (iv) sent by telex, telegraph or other facsimile transmission
      as
      follows:

    

    If
      to
      Company addressed or delivered in person to:

    

    Cytomedix,
      Inc. 

    Attn:
      Chief Financial Officer

    416
      Hungerford Dr., Suite 330

    Rockville,
      Maryland 20850

    

    If
      to the
      Holder, addressed or delivered in person to:

    

    _________________________

    

    _________________________

    

    _________________________

     

    or
      to
      such other address as either party may designate by notice in accordance with
      this Section.

    

    Any
      such
      notice or communication, if given or made by prepaid, registered or certified
      mail or by recorded express delivery, shall be deemed to have been made when
      actually received, but not later than three (3) business days after the same
      was
      properly posted or given to such express delivery service and if made properly
      by telex, telecopy or other facsimile transmission such notice or communication
      shall be deemed to have been made at the time of dispatch.

    

    9.12 Severability.
      If any
      portion of this Warrant is held invalid, illegal or unenforceable, such
      determination shall not impair the enforceability of the remaining terms and
      provisions herein, which may remain effective, and to this end this Warrant
      is
      declared to be severable.

    

    9.13 Waiver.
      No
      waiver
      of a default, breach or other violation of any provision of this Warrant shall
      operate or be construed as a waiver of any subsequent default, breach or other
      violation or limit or restrict any right or remedy otherwise available. No
      delay
      or omission on the part of the Holder to exercise any right or power arising
      by
      reason of a default shall impair any such right or power or prevent its exercise
      at any time during the continuance thereof

    

    
      
         

      

      
         

        
          

        

      

      
         

      

       

    

    9.14 Gender
      and Pronouns.
      Throughout this Warrant, the masculine shall include the feminine and neuter
      and
      the singular shall include the plural and vice versa as the context
      requires.

    

    9.15 Entire
      Agreement.
      This
      Warrant constitutes
      the entire agreement of the parties with respect to the subject matter contained
      herein, and supersedes any and all other prior agreements, oral or written,
      with
      respect to the subject matter contained herein.

    

    9.16 Remedies.
      The
      Company acknowledges that a breach by it of its obligations hereunder will
      cause
      irreparable harm to the Holder, by vitiating the intent and purpose of the
      transaction contemplated hereby. Accordingly, the Company acknowledges that
      the
      remedy at law for a breach of its obligations under this Warrant will be
      inadequate and agrees, in the event of a breach or threatened breach by the
      Company of the provisions of this Warrant, that the Holder shall be entitled,
      in
      addition to all other available remedies at law or in equity, to an injunction
      or injunctions restraining, preventing or curing any breach of this Warrant
      and
      to enforce specifically the terms and provisions thereof, without the necessity
      of showing economic loss and without any bond or other security being
      required. 

    IN
      WITNESS WHEREOF, the
      Company has caused this Warrant to be duly executed and delivered as of the
      _________day of _______________, 2006.

     

    
      	 	 	 
	 	CYTOMEDIX,
              INC.
	 
 	 
 	 
 
	 	By:  	 
	 	
              
Andrew
              Maslan
	 	Chief
              Financial Officer

    

     

    
      
         

      

      
         

        
          

        

      

      
         

      

    

     

    CLASS
      D WARRANT

    EXERCISE/ASSIGNMENT
      FORM

    1. CYTOMEDIX,
      INC.

    

    The
      undersigned _______________, pursuant to the provisions of the within Warrant,
      hereby elects to purchase _____ shares of Common Stock of Cytomedix, Inc.
      covered by the within Warrant.

    

    Dated:
      __________________  

    Signature______________________

    
      	 	Address
	 	___________________________
	 	___________________________

    

    

    

    Number
      of
      shares of Common Stock beneficially owned or deemed beneficially owned by the
      Holder on the date of Exercise: _________________________

    

    ASSIGNMENT

    

    FOR
      VALUE
      RECEIVED, _________________ hereby sells, assigns and transfers unto
      __________________ the within Warrant and all rights evidenced thereby and
      does
      irrevocably constitute and appoint _____________, attorney, to transfer the
      said
      Warrant on the books of the within named corporation.

    

    Dated:
      _________________  

    Signature___________________________

    
      
        	 	Address
	 	___________________________
	 	___________________________

      

    

     

    PARTIAL
      ASSIGNMENT

    

    FOR
      VALUE
      RECEIVED, _________________ hereby sells, assigns and transfers unto
      __________________ the right to purchase _________ shares of Warrant Stock
      evidenced by the within Warrant together with all rights therein, and does
      irrevocably constitute and appoint ___________________, attorney, to transfer
      that part of the said Warrant on the books of the within named
      corporation.

    

    Dated:
      _________________  

    Signature___________________________

    
      
        	 	Address
	 	___________________________
	 	___________________________

      

    

     

    FOR
      USE BY THE ISSUER ONLY:

    

    This
      Warrant No. W-___ canceled (or transferred or exchanged) this _____ day of
      ___________, _____, shares of Common Stock issued therefor in the name of
      _______________, Warrant No. W-_____ issued for ____ shares of Common Stock
      in
      the name of _______________.Exhibit
      4.2

     

    REGISTRATION
      RIGHTS AGREEMENT

    

    This
      REGISTRATION RIGHTS AGREEMENT (“Agreement”), dated as of April 12, 2006, by and
      among CYTOMEDIX, INC., a Delaware corporation, (“Company”), and each of the
      undersigned holder of Class D Warrants, together with any assignee or transferee
      of all of their respective registration rights hereunder
      (“Warrantholders”).

    

    
      
        1.
          DEFINITIONS.

      

    

    

    As
      used
      in this Agreement, the following terms shall have the following
      meanings:

     

    (a) “Agreement”
      means this Registration Rights Agreement.

    

    (b) “Common
      Stock” means the Company’s common stock, par value $0.0001.

    

    (c) “Company”
      means Cytomedix, Inc., a Delaware corporation.

    

    (d) “Exchange
      Act” means the Securities Exchange Act of 1934, as amended.

    

    (e) “Register,”
      “registered,” and “registration” refer to a registration effected by preparing
      and filing a Registration Statement(s) in compliance with the Securities Act
      and
      pursuant to Rule 415, and the declaration or ordering of effectiveness of such
      Registration Statement(s) by the SEC. 

    

    (f) “Registrable
      Securities” means the Warrant Shares and any shares of Common Stock issued or
      issuable as a dividend on or in exchange for or otherwise with respect to any
      of
      the Warrant Shares, provided,
      that
      any shares of Common Stock which have been sold pursuant to a Registration
      Statement or which may be sold without registration or restriction (including
      volume limitations) shall cease to be Registrable Securities
      hereunder.

    

    (g) “Registration
      Period” means the period beginning upon the effectiveness of a Registration
      Statement covering the resale of the Registrable Securities and ending upon
      the
      earlier of (i) the date on which all of the Registrable Securities have been
      sold and (ii) the date on which the Registrable Securities may be immediately
      sold to the public without registration or restriction (including without
      limitation as to volume by each holder thereof) under the Securities
      Act.

    

    (h) “Registration
      Statement” means a registration statement of the Company under the Securities
      Act.

    

    
      
         

      

      
         

        
          

        

      

      
         

      

       

    

    (i) “Rule
      415” means Rule 415 under the Securities Act or any successor rule providing for
      offering securities on a continuous basis. 

    

    (j) “SEC”
      means the United States Securities and Exchange Commission.

    

    (k) “Securities
      Act” means the Securities Act of 1933, as amended.

    

    (l) “Subscription
      Agreement” means the Subscription Agreement of even date herewith between the
      Company and the Warrantholder relating to the Warrantholders investment in
      the
      Warrants.

    

    (m) “Warrantholders”
      means the current holders of the Warrants and any transferee or assignee who
      agrees to become bound by the provisions of this Agreement.

    

    (n) “Warrants”
      means the Company’s Class D Warrants.

    

    (o) “Warrant
      Shares” means the shares of Common Stock issuable upon exercise of the
      Warrants.

    

    2. REGISTRATION.

    

    (a) If
      at any
      time from and after the date of this Agreement, the Company proposes to register
      any offering of shares of its Common Stock under the Securities Act, the
      Registrable Securities shall be included in the offering covered by the
      Registration Statement.

    

    (b)
       Before
      filing a Registration Statement or prospectus or any amendments or supplements
      thereto, the Company shall furnish copies of all such documents proposed to
      be
      filed, to the Warrantholder, its counsel and the representative of the
      underwriters, if any, as reasonably requested by such Warrantholder, its counsel
      and/or representative of the underwriters. Such documents will be subject to
      the
      review and comment (none of which comments the Company will have an obligation
      to accept) of the Warrantholder, its counsel and the representative of the
      underwriters, if any. The Company shall not be required to file any registration
      statement or prospectus or any amendments or supplements thereto to which the
      representative of the underwriters, if any, reasonably shall object on a timely
      basis. 

    

    (c) The
      Registration Statement, to the extent allowable under the Securities Act and
      the
      rules and regulations promulgated thereunder, shall state that such Registration
      Statement also covers such indeterminate number of additional shares of Common
      Stock as may become issuable upon exercise of the Warrants (i) to prevent
      dilution resulting from stock splits, stock dividends or similar transactions
      as
      and if so provided in the Warrant or (ii) by reason of changes in the exercise
      price of the Warrants as and if so provided in the Warrant. 

     

    
      
         

      

      
         

        
          

        

      

      
         

      

    

    

    3. OBLIGATIONS
      OF THE COMPANY.

    

    In
      connection with the registration of the Registrable Securities, the Company
      shall have the following obligations:

    

    (a) When
      so
      required by Section 2(a) of this Agreement, the Company shall prepare and file
      with the SEC, a Registration Statement with respect to the number of Registrable
      Securities provided in Section 2(a) and 2(c), and thereafter use its best
      efforts to cause such Registration Statement relating to Registrable Securities
      to become effective as soon as possible after such filing. The Company shall
      keep the Registration Statement effective pursuant to Rule 415 at all times
      until the end of the Registration Period. The Registration Statement (including
      any amendments or supplements thereto and prospectuses contained therein) shall
      not contain any untrue statement of a material fact or omit to state a material
      fact required to be stated therein, or necessary to make the statements therein,
      in light of the circumstances, under which they were made, not
      misleading.

    

    (b) The
      Company shall prepare and file with the SEC such amendments (including
      post-effective amendments) and supplements to the Registration Statements and
      the prospectus used in connection with the Registration Statements as may be
      necessary to keep the Registration Statements effective at all times during
      the
      Registration Period, and, during such period, comply with the provisions of
      the
      Securities Act with respect to the disposition of all Registrable Securities
      of
      the Company covered by the Registration Statements until such time as all of
      such Registrable Securities have been disposed of in accordance with the
      intended methods of disposition by the seller or sellers thereof as set forth
      in
      the Registration Statements.

    

    (c) The
      Company shall furnish to each Warrantholder whose Registrable Securities are
      included in a Registration Statement such number of copies of a prospectus,
      including a preliminary prospectus, and all amendments and supplements thereto
      and such other documents as such Warrantholder may reasonably request in order
      to facilitate the disposition of the Registrable Securities owned by such
      Warrantholder in accordance with the Registration Statement. 

    

    (d)
       The
      Company shall use its best efforts to register or qualify the Registrable
      Securities under such other securities or blue sky laws of such jurisdictions
      as
      the Warrantholder reasonably shall request. However, the Company shall not
      be
      obligated, by reason thereof, to qualify as a foreign corporation or file any
      general consent to service of process under the laws of any such jurisdiction
      or
      subject itself to taxation as doing business in any such jurisdiction.

    

    (e) The
      Company will promptly respond to any and all comments received from the SEC
      (which comments shall promptly be made available to the Warrantholders upon
      request, unless they relate to information for which the Company has sought
      confidential treatment), with a view towards causing each Registration Statement
      or any amendment thereto to be declared effective by the SEC as soon as
      practicable, shall promptly file an acceleration request as soon as practicable
      following the resolution or clearance of all SEC comments or, if applicable,
      following notification by the SEC that any such Registration Statement or any
      amendment thereto will not be subject to review, shall promptly file with the
      SEC a final prospectus as soon as practicable following receipt by the Company
      from the SEC of an order declaring the Registration Statement
      effective.

    

    
      
         

      

      
         

        
          

        

      

      
         

      

       

    

    (f) The
      Company may enter into an underwriting agreement which shall be similar in
      form,
      scope and substance as is customary in underwritten offerings, and may take
      all
      such other actions in connection therewith in order to expedite or facilitate
      the disposition of the Registrable Securities. The Company shall select the
      underwriter or underwriters to be engaged and shall designate the
      representative, if any, of the underwriters so engaged. In such connection,
      the
      Company shall make such representations and warranties to the underwriters
      with
      respect to the business of the Company, the registration statement, the
      prospectus and the documents, if any, incorporated or deemed to be incorporated
      by reference in the registration statement, in each case in form, substance
      and
      scope as are customarily made by issuers to underwriters in underwritten
      (initial or secondary, as applicable) offerings and confirm the same if and
      when
      requested. The Company shall also obtain opinions of counsel to the Company
      and
      updates thereof, which counsel and opinions (in form, scope and substance)
      shall
      be reasonably satisfactory to the representative of the underwriters.

    

    (g) The
      Company shall use its best efforts to prevent the issuance of any stop order
      or
      other suspension of effectiveness of any Registration Statement, and, if such
      an
      order is issued, to obtain the withdrawal of such order at the earliest possible
      moment and to notify each Warrantholder who holds Registrable Securities being
      sold (or, in the event of an underwritten offering, the managing underwriters)
      of the issuance of such order and the resolution thereof.

     

    (h) The
      Company shall make available for inspection by any Warrantholder or
      Warrantholder’s counsel, or any underwriter participating in any disposition
      pursuant to a Registration Statement (collectively, the “Inspectors”) all
      pertinent financial and other records, and pertinent corporate documents and
      properties of the Company (collectively, the “Records”), as shall be reasonably
      deemed necessary by each Inspector to enable each Inspector to exercise its
      due
      diligence responsibility, and cause the Company’s officers, directors and
      employees to supply all information which any Inspector may reasonably request
      for purposes of such due diligence; provided,
      however,
      that
      each Inspector shall hold in confidence and shall not make any disclosure
      (except to a Warrantholder) of any Record or other information which the Company
      determines in good faith to be confidential, and of which determination the
      Inspectors are so notified, unless (i) the disclosure of such Records is
      necessary to avoid or correct a misstatement or omission in any Registration
      Statement, (ii) the release of such Records is ordered pursuant to a subpoena
      or
      other order from a court or government body of competent jurisdiction, or (iii)
      the information in such Records has been made generally available to the public
      other than by disclosure in violation of this or any other agreement. The
      Company shall not be required to disclose any confidential information in such
      Records to any Inspector until and unless such Inspector shall have entered
      into
      confidentiality agreements (in form and substance satisfactory to the Company).
      Each Inspector agrees that it shall, upon learning that disclosure of such
      Records is sought in or by a court or governmental body of competent
      jurisdiction or through other means, give prompt notice to the Company and
      allow
      the Company, at its expense, to undertake appropriate action to prevent
      disclosure of, or to obtain a protective order for, the Records deemed
      confidential. Nothing herein (or in any other confidentiality agreement between
      the Company and any Warrantholder) shall be deemed to limit the Warrantholder’s
      ability to sell Registrable Securities in a manner which is otherwise consistent
      with applicable laws and regulations.

     

    
      
         

      

      
         

        
          

        

      

      
         

      

       

    

    (i) The
      Company shall in connection with the Registration Statement covering the
      Registrable Securities (i) cause all the Registrable Securities covered by
      the
      Registration Statement to be listed on each national securities exchange on
      which securities of the same class or series issued by the Company are then
      listed, if any, if the listing of such Registrable Securities is then permitted
      under the rules of such exchange, or (ii) to the extent the securities of the
      same class or series are not then listed on a national securities exchange,
      secure the designation and quotation, of all the Registrable Securities covered
      by the Registration Statement on Nasdaq or, if not eligible for Nasdaq, on
      Nasdaq SmallCap or, if not eligible for Nasdaq or Nasdaq SmallCap, on the
      Over-The-Counter Bulletin Board (“OTCBB”) or the Pink Sheets, LLC (“Pink
      Sheets”) and, without limiting the generality of the foregoing, to arrange for
      at least two market makers to register with the National Association of
      Securities Dealers, Inc. (“NASD”) as such with respect to such Registrable
      Securities.

    

    (j) The
      Company shall provide a transfer agent and registrar, which may be a single
      entity, for the Registrable Securities not later than the effective date of
      the
      Registration Statement.

    

    (k) The
      Company shall cooperate with the Warrantholders who hold Registrable Securities
      being offered and the managing underwriter or underwriters, if any, to
      facilitate the timely preparation and delivery of certificates (not bearing
      any
      restrictive legends) representing shares of Common Stock and enable such
      certificates to be in such denominations or amounts, as the case may be, as
      the
      managing underwriter or underwriters, if any, or the Warrantholders may
      reasonably request and registered in such names as the managing underwriter
      or
      underwriters, if any, or the Warrantholders may request. The Company shall
      deliver, and shall cause legal counsel selected by the Company to deliver,
      to
      the transfer agent for the Registrable Securities (with copies to the
      Warrantholders, whose Registrable Securities are included in such Registration
      Statement) an instruction that certain shares have been registered and may
      be
      transferred.

     

    
      
         

      

      
         

        
          

        

      

      
         

      

    

    

    4. OBLIGATIONS
      OF THE WARRANTHOLDERS.

    

    In
      connection with the registration of the Registrable Securities, the
      Warrantholders shall have the following obligations:

    

    (a) It
      shall
      be a condition precedent to the obligations of the Company to complete the
      registration pursuant to this Agreement with respect to the Registrable
      Securities of a particular Warrantholder that such Warrantholder shall furnish
      to the Company such information regarding itself, the Registrable Securities
      held by it and the intended method of disposition of the Registrable Securities
      held by it as shall be reasonably required to effect the registration of such
      Registrable Securities and shall execute such documents in connection with
      such
      registration as the Company may reasonably request. At least five (5) business
      days prior to the first anticipated filing date of the Registration Statement,
      the Company shall notify each Warrantholder of the information the Company
      requires from each such Warrantholder.

    

    (b) Each
      Warrantholder, by such Warrantholder’s acceptance of the Registrable Securities,
      agrees to cooperate with the Company as reasonably requested by the Company
      in
      connection with the preparation and filing of the Registration Statements
      hereunder, unless such Warrantholder has notified the Company in writing of
      such
      Warrantholder’s election to exclude all of such Warrantholder’s Registrable
      Securities from the Registration Statements, except to the extent any such
      requested information is required by the SEC or by applicable law to be included
      in any such Registration Statement.

    

    (c) In
      the
      event, the Company decides to engage the services of an underwriter, each
      Warrantholder agrees to enter into and perform such Warrantholder’s obligations
      under an underwriting agreement, in usual and customary form, including, without
      limitation, customary indemnification and contribution obligations, with the
      managing underwriter of such offering and take such other actions as are
      reasonably required in order to expedite or facilitate the disposition of the
      Registrable Securities, unless such Warrantholder has notified the Company
      in
      writing of such Warrantholder’s election to exclude all of such Warrantholder’s
      Registrable Securities from such Registration Statement.

    

    (d) Each
      Warrantholder agrees that, upon receipt of any notice from the Company of the
      happening of any event described in Section 3(g), such Warrantholder will
      immediately discontinue disposition of Registrable Securities pursuant to the
      Registration Statement covering such Registrable Securities until such
      Warrantholder’s receipt of the copies of the supplemented or amended prospectus.
      If so directed by the Company, such Warrantholder shall deliver to the Company
      (at the expense of the Company) or destroy (and deliver to the Company a
      certificate of destruction) all copies in such Warrantholder’s possession, of
      the prospectus covering such Registrable Securities current at the time of
      receipt of such notice.

    

    
      
         

      

      
         

        
          

        

      

      
         

      

       

    

    (e) No
      Warrantholder may participate in any underwritten registration hereunder unless
      such Warrantholder (i) agrees to sell such Warrantholder’s Registrable
      Securities on the basis provided in any underwriting arrangements in usual
      and
      customary form entered into by the Company, (ii) completes and executes all
      questionnaires, powers of attorney, indemnities, underwriting agreements and
      other documents reasonably required under the terms of such underwriting
      arrangements, and (iii) agrees to pay its pro rata share of all underwriting
      discounts and commissions and any expenses in excess of those payable by the
      Company pursuant to Section 5 below.

    

    5. EXPENSES
      OF REGISTRATION.

    

    All
      reasonable expenses (other than underwriting discounts and commissions and
      stock
      transfer taxes, if any, and such fees for counsel, printing, registration and
      other fees as state securities officials may require that holders of shares
      pay)
      including, without limitation, all registration, listing and qualification
      fees,
      printers and accounting fees, the fees and disbursements of counsel for the
      Company, shall be paid by the Company. 

    

    
      
        6.
          INDEMNIFICATION.

      

    

    

    (a) To
      the
      extent permitted by law, the Company will indemnify, hold harmless and defend
      (i) each Warrantholder who holds such Registrable Securities, (ii) the
      directors, officers, partners and each person who controls any Warrantholder
      within the meaning of the Securities Act or the Exchange Act, if any, (iii)
      any
      underwriter (as defined in the Securities Act) for the Warrantholders, and
      (iv)
      the directors, officers, partners, employees and each person who controls any
      such underwriter within the meaning of the Securities Act or the Exchange Act,
      if any (each, an “Indemnified Person”), against any joint or several losses,
      claims, damages, liabilities or expenses (collectively, together with actions,
      proceedings or inquiries by any regulatory or self-regulatory organization,
      whether commenced or threatened, in respect thereof, “Claims”) to which any of
      them may become subject insofar as such Claims arise out of or are based upon:
      (i) any untrue statement or alleged untrue statement of a material fact in
      a
      Registration Statement or the omission or alleged omission to state therein
      a
      material fact required to be stated or necessary to make the statements therein,
      in light of the circumstances under which they were made, not misleading; (ii)
      any untrue statement or alleged untrue statement of a material fact contained
      in
      any preliminary prospectus if used prior to the effective date of such
      Registration Statement, or contained in the final prospectus (as amended or
      supplemented, if the Company files any amendment thereof or supplement thereto
      with the SEC) or the omission or alleged omission to state therein any material
      fact necessary to make the statements made therein, in light of the
      circumstances under which the statements therein were made, not misleading;
      or
      (iii) any violation or alleged violation by the Company of the Securities Act,
      the Exchange Act, any other law, including, without limitation, any state
      securities law, or any rule or regulation thereunder relating to the offer
      or
      sale of the Registrable Securities (the matters in the foregoing clauses (i)
      through (iii) being, collectively, “Violations”). The Company shall reimburse
      the Indemnified Person for any reasonable legal fees or other reasonable
      expenses incurred by them in connection with investigating or defending any
      such
      Claim, subject to Section 6(c). Notwithstanding anything to the contrary
      contained herein, the indemnification agreement contained in this Section 6(a):
      (i) shall not apply to a Claim arising out of or based upon a Violation which
      occurs in reliance upon and in conformity with information furnished in writing
      to the Company by any Indemnified Person or underwriter for such Indemnified
      Person expressly for use in connection with the preparation of such Registration
      Statement or any such amendment thereof or supplement thereto, if such
      prospectus was timely made available by the Company pursuant to Section 3(c)
      hereof (ii) shall not apply to amounts paid in settlement of any Claim if such
      settlement is effected without the prior written consent of the Company, which
      consent shall not be unreasonably withheld; (iii) with respect to any
      preliminary prospectus, shall not inure to the benefit of any Indemnified
      Person, if the untrue statement or omission of material fact contained in the
      preliminary prospectus was corrected on a timely basis in the prospectus, as
      then amended or supplemented, and such corrected prospectus was timely made
      available by the Company and the Indemnified Person was promptly advised in
      writing not to use the incorrect prospectus prior to the use giving rise to
      a
      Violation and such Indemnified Person, notwithstanding such advice, used it,
      and
      (iv) in the case of gross negligence or willful misconduct by such
      Warrantholder. 

    

    
      
         

      

      
         

        
          

        

      

      
         

      

       

    

    (b) In
      connection with any Registration Statement in which a Warrantholder is
      participating, each such Warrantholder agrees to indemnify, hold harmless and
      defend, to the same extent and in the same manner set forth in Section 6(a),
      the
      Company, each of its directors, each of its officers who signs the Registration
      Statement, each person, if any, who controls the Company within the meaning
      of
      the Securities Act or the Exchange Act, any underwriter and any other
      stockholder selling securities pursuant to the Registration Statement or any
      of
      its directors or officers or any person who controls such stockholder or
      underwriter within the meaning of the Securities Act or the Exchange Act
      (collectively and together with an Indemnified Person, an “Indemnified Party”),
      against any Claim to which any of them may become subject, under the Securities
      Act, the Exchange Act or otherwise, insofar as such Claim arises out of or
      is
      based upon any Violation by such Warrantholder, in each case to the extent
      (and
      only to the extent) that such Violation occurs in reliance upon and in
      conformity with written information furnished to the Company by such
      Warrantholder expressly for use in connection with such Registration Statement
      (or prospectus forming a part thereof); and subject to Section 6(c) such
      Warrantholder will reimburse any legal or other expenses incurred by them in
      connection with investigating or defending any such Claim; provided,
      however,
      that
      the indemnity agreement contained in this Section 6(b) shall not apply (i)
      to
      amounts paid in settlement of any Claim if such settlement is effected without
      the prior written consent of such Warrantholder, which consent shall not be
      unreasonably withheld and (ii) in the case of gross negligence or willful
      misconduct by the Company; provided,
      further,
      however,
      that
      the Warrantholder shall be liable under this Agreement (including this Section
      6(b) and Section 7) for only that amount as does not exceed the net proceeds
      to
      such Warrantholder as a result of the sale of Registrable Securities pursuant
      to
      such Registration Statement. Such indemnity shall remain in full force and
      effect regardless of any investigation made by or on behalf of such Indemnified
      Party and shall survive the transfer of the Registrable Securities by the
      Warrantholders. Notwithstanding anything to the contrary contained herein,
      the
      indemnification agreement contained in this Section 6(b) with respect to any
      preliminary prospectus shall not inure to the benefit of any Indemnified Party
      if the untrue statement or omission of material fact contained in the
      preliminary prospectus was corrected on a timely basis in the prospectus, as
      then amended or supplemented.

    

    
      
         

      

      
         

        
          

        

      

      
         

      

       

    

    (c) Promptly
      after receipt by an Indemnified Person or Indemnified Party under this Section
      6
      of notice of the commencement of any action (including any governmental action),
      such Indemnified Person or Indemnified Party shall, if a Claim in respect
      thereof is to be made against any indemnifying party under this Section 6,
      deliver to the indemnifying party a written notice of the commencement thereof,
      and the indemnifying party shall have the right to participate in, and, to
      the
      extent the indemnifying party so desires, jointly with any other indemnifying
      party similarly noticed, to assume control of the defense thereof with counsel
      mutually satisfactory to the indemnifying party and the Indemnified Person
      or
      the Indemnified Party, as the case may be; provided,
      however,
      that an
      Indemnified Person or lndemnified Party shall have the right to retain its
      own
      counsel with the fees and expenses to be paid by the indemnifying party, if,
      in
      the reasonable opinion of counsel retained by the indemnifying party, the
      representation by such counsel of the Indemnified Person or Indemnified Party
      and the indemnifying party would be inappropriate due to actual or potential
      differing interests between such Indemnified Person or Indemnified Party and
      any
      other party represented by such counsel in such proceeding. The indemnifying
      party shall pay for only one separate legal counsel for the Indemnified Persons
      or the Indemnified Parties, as applicable, and such legal counsel shall be
      selected by Warrantholders holding at least seventy-five percent (75%) of the
      Registrable Securities included in the Registration Statement to which the
      Claim
      relates if the Warrantholders are entitled to indemnification hereunder, or
      the
      Company, if the Company is entitled to indemnification hereunder, as applicable.
      The failure to deliver written notice to the indemnifying party within a
      reasonable time of the commencement of any such action shall not relieve such
      indemnifying party of any liability to the Indemnified Person or Indemnified
      Party under this Section 6, except to the extent that the indemnifying party
      is
      actually prejudiced in its ability to defend such action. The indemnification
      required by this Section 6 shall be made by periodic payments of the amount
      thereof during the course of the investigation or defense, as such expense,
      loss, damage or liability is incurred and is due and payable.

    

    7. CONTRIBUTION.

    

    To
      the
      extent any indemnification by an indemnifying party is prohibited or limited
      by
      law, the indemnifying party agrees to make the maximum contribution with respect
      to any amounts for which it would otherwise be liable under Section 6 to the
      fullest extent permitted by law; provided,
      however,
      that
      (i) no contribution shall be made under circumstances where the maker would
      not
      have been liable for indemnification under the fault standards set forth in
      Section 6, (ii) no seller of Registrable Securities guilty of fraudulent
      misrepresentation (within the meaning of Section 11(f) of the Securities Act)
      shall be entitled to contribution from any seller of Registrable Securities
      who
      was not guilty of such fraudulent misrepresentation, and (iii) contribution
      (together with any indemnification or other obligations under this Agreement)
      by
      any seller of Registrable Securities shall be limited in amount to the net
      amount of proceeds received by such seller from the sale of such Registrable
      Securities.

    

    
      
         

      

      
         

        
          

        

      

      
         

      

    

     

    8. RESERVED.

    

    9. REPORTS
      UNDER THE EXCHANGE ACT.

    

    With
      a
      view to making available to the Warrantholders the benefits of Rule 144
      promulgated under the Securities Act or any other similar rule or regulation
      of
      the SEC that may at any time permit the Warrantholders to sell Registrable
      Securities to the public without registration (“Rule 144”), the Company agrees
      to:

    

    (a) make
      and
      keep public information available, as those terms are understood and defined
      in
      Rule 144 as soon as practicable after Confirmation;

    

    (b) file
      with
      the SEC in a timely manner all reports and other documents required of the
      Company under the Securities Act and the Exchange Act so long as the Company
      remains subject to such requirements and the filing of such reports and other
      documents is required for the applicable provisions of Rule 144;
      and

    

    (c) furnish
      to each Warrantholder so long as such Warrantholder owns Registrable Securities,
      promptly upon request, (i) a written statement by the Company that it has
      complied with the reporting requirements of Rule 144, the Securities Act and
      the
      Exchange Act, (ii) a copy of the most recent annual or quarterly report of
      the
      Company and such other reports and documents so filed by the Company, and (iii)
      such other information as may be reasonably requested to permit the
      Warrantholders to sell such securities pursuant to Rule 144 without
      registration.

    

    10. AMENDMENT
      OF REGISTRATION RIGHTS.

    

    Provisions
      of this Agreement may be amended and the observance thereof may be waived
      (either generally or in a particular instance and either retroactively or
      prospectively), only with written consent of the Company, and Warrantholders
      who
      hold at least seventy-five percent (75%) of the Registrable Securities. Any
      amendment or waiver effected in accordance with this Section 10 shall be binding
      upon each Warrantholder and the Company.

    

    11. MISCELLANEOUS.

    

    (a) A
      person
      or entity is deemed to be a holder of Registrable Securities whenever such
      person or entity owns of record such Registrable Securities. If the Company
      receives conflicting instructions, notices or elections from two or more persons
      or entities with respect to the same Registrable Securities, the Company shall
      act upon the basis of instructions, notice or election received from the
      registered owner of such Registrable Securities.

    

    
      
         

      

      
         

        
          

        

      

      
         

      

       

    

    (b) Any
      notices required or permitted to be given under the terms hereof shall be sent
      by certified or registered mail (return receipt requested) or delivered
      personally or by courier (including a recognized overnight delivery service)
      or
      by facsimile and shall be effective five days after being placed in the mail,
      if
      mailed by regular United States mail, or upon receipt, if delivered personally
      or by courier (including a recognized overnight delivery service) or by
      facsimile, in each case addressed to a party. The addresses for such
      communications shall be unless otherwise notified:

    

    If
      to the
      Company:

    

    Cytomedix,
      Inc.

    416
      Hungerford Dr.

    Suite
      330

    Rockville,
      Maryland 20850

    

    Attention:
      Chief Financial Officer

    

    With
      copy
      to:

    

    Williams
      & Anderson PLC

    111
      Center Street, 22nd Floor

    Little
      Rock, Arkansas 72201

    Attention:
       A.
      Heath
      Abshure

    

    If
      to a
      Warrantholder: to the address set forth immediately below such Warrantholder’s
      name on the signature pages to the Subscription Agreement.

    

    (c) Failure
      of any party to exercise any right or remedy under this Agreement or otherwise,
      or delay by a party in exercising such right or remedy, shall not operate as
      a
      waiver thereof.

    

    (d) THIS
      AGREEMENT SHALL BE ENFORCED, GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE
      LAWS OF THE STATE OF DELAWARE, WITHOUT REGARD TO THE PRINCIPLES OF CONFLICT
      OF
      LAWS. THE PARTIES HERETO HEREBY SUBMIT TO THE EXCLUSIVE JURISDICTION OF THE
      STATE AND FEDERAL COURTS LOCATED IN MONTGOMERY COUNTY, MARYLAND WITH RESPECT
      TO
      ANY DISPUTE ARISING UNDER THIS AGREEMENT, THE AGREEMENTS ENTERED INTO IN
      CONNECTION HEREWITH OR THE TRANSACTIONS CONTEMPLATED HEREBY OR THEREBY. BOTH
      PARTIES IRREVOCABLY WAIVE THE DEFENSE OF AN INCONVENIENT FORUM TO THE
      MAINTENANCE OF SUCH SUIT OR PROCEEDING. BOTH PARTIES FURTHER AGREE THAT SERVICE
      OF PROCESS UPON A PARTY MAILED BY FIRST CLASS MAIL SHALL BE DEEMED IN EVERY
      RESPECT EFFECTIVE SERVICE OF PROCESS UPON THE PARTY IN ANY SUCH SUIT OR
      PROCEEDING. NOTHING HEREIN SHALL AFFECT ANY PARTY’S RIGHT TO SERVE PROCESS IN
      ANY OTHER MANNER PERMITTED BY LAW. ALL PARTIES AGREE THAT A FINAL NON-APPEALABLE
      JUDGMENT IN ANY SUCH SUIT OR PROCEEDING SHALL BE CONCLUSIVE AND MAY BE ENFORCED
      IN OTHER JURISDICTIONS BY SUIT ON SUCH JUDGMENT OR IN ANY OTHER LAWFUL MANNER.
      THE PARTY WHICH DOES NOT PREVAIL IN ANY DISPUTE ARISING UNDER THIS AGREEMENT
      SHALL BE RESPONSIBLE FOR ALL FEES AND EXPENSES, INCLUDING ATTORNEYS FEES,
      INCURRED BY THE PREVAILING PARTY IN CONNECTION WITH SUCH DISPUTE.

    

    
      
         

      

      
         

        
          

        

      

      
         

      

       

    

    (e) In
      the
      event that any provision of this Agreement is invalid or unenforceable under
      any
      applicable statute or rule of law, then such provision shall be deemed
      inoperative to the extent that it may conflict therewith and shall be deemed
      modified to conform with such statute or rule of law. Any provision hereof
      which
      may prove invalid or unenforceable under any law shall not affect the validity
      or enforceability of any other provision hereof

    

    (f) This
      Agreement constitutes the entire agreement among the parties hereto with respect
      to the subject matter hereof. There are no restrictions, promises, warranties
      or
      undertakings, other than those set forth or referred to herein and therein.
      This
      Agreement supersedes all prior agreements and understandings among the parties
      hereto with respect to the subject matter hereof.

    

    (g) This
      Agreement shall be binding upon and inure to the benefit of the parties and
      their successors and assigns.

    

    (h) The
      headings in this Agreement are for convenience of reference only and shall
      not
      form part of, or affect the interpretation of, this Agreement.

    

    (i) This
      Agreement may be executed in two or more counterparts, each of which shall
      be
      deemed an original but all of which shall constitute one and the same agreement
      and shall become effective when counterparts have been signed by each party
      and
      delivered to the other party. This Agreement, once executed by a party, may
      be
      delivered to the other party hereto by facsimile transmission of a copy of
      this
      Agreement bearing the signature of the party so delivering this
      Agreement.

    

    (j) Each
      party shall do and perform, or cause to be done and performed, all such further
      acts and things, and shall execute and deliver all such other agreements,
      certificates, instruments and documents, as the other party may reasonably
      request in order to carry out the intent and accomplish the purposes of this
      Agreement and the consummation of the transactions contemplated
      hereby.

    

    (k) Except
      as
      otherwise provided herein, all consents and other determinations to be made
      by
      the Warrantholders pursuant to this Agreement shall be made by Warrantholders
      owning at least seventy-five percent (75%) of the Registrable Securities,
      determined as if all of the Warrants then outstanding have been converted into
      Registrable Securities.

    

    (l) The
      Company acknowledges that a breach by it of its obligations hereunder will
      cause
      irreparable harm to each Warrantholder by vitiating the intent and purpose
      of
      the transactions contemplated hereby. Accordingly, the Company acknowledges
      that
      the remedy at law for breach of its obligations under this Agreement will be
      inadequate and agrees, in the event of a breach or threatened breach by the
      Company of any of the provisions under this Agreement, that each Warrantholder
      shall be entitled, in addition to all other available remedies in law or in
      equity, and in addition to the penalties assessable herein, to an injunction
      or
      injunctions restraining, preventing or curing any breach of this Agreement
      and
      to enforce specifically the terms and provisions hereof without the necessity
      of
      showing economic loss and without any bond or other security being
      required.

    

    
      
         

      

      
         

        
          

        

      

      
         

      

       

    

    (m) The
      language used in this Agreement will be deemed to be the language chosen by
      the
      parties to express their mutual intent, and no rules of strict construction
      will
      be applied against any party.

    

    IN
      WITNESS WHEREOF, the Company and the undersigned Warrantholder have caused
      this
      Agreement to be duly executed as of the date first above written.

     

     

    
      	CYTOMEDIX, INC.	WARRANTHOLDER
              (S):
	 	 
	 	 
	_____________________________	_____________________________
	Andrew Maslan 	 
	Chief Financial Officer	_____________________________

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