Document:

EXHIBIT 10.19

October 29, 2001

      The undersigned vendor, Vijay Amritraj ("Vendor"), acknowledges that it
has performed certain services for and on behalf of Vertical Computer Systems,
Inc. ("Company") for which invoices in the amount of the approximate amount of
Thirty-Seven Thousand Five Hundred Dollars and No Cents ($37,500.00) have been
issued by Vendor. Company agrees that it shall issue Seven Hundred Fifty
Thousand (750,000) shares of its common stock (the "Stock" herein), Vijay
Amritraj:; and Company shall cause to be filed immediately a Registration
Statement on Form S-8 registering the Stock, to permit the sale of the Stock as
a means of reducing Company's outstanding obligation to Vendor. Provided,
however, the Stock shall be sold into the public in an orderly and nondisruptive
manner at the rate of no more than fifteen percent (15%) of the total shares of
stock issued per week. Company shall have the express right, at any time, to pay
any outstanding amounts owed to Vendor and, upon such payment, Vendor shall
return any remaining stock immediately to Company. In the event that the net
proceeds, after deducting any commissions, from Vendor's sale of Stock are less
than the amount of $37,500.00, Company shall pay Vendor the difference between
$37,500.00 and the net proceeds in cash within ten (10) days of presentation by
Vendor to Company of documentation of the amount of net proceeds. Further, if
the Stock is sold by Vendor, after deducting any commissions, for a total of
more than $37,500.00, then, any Stock remaining will either (a) be returned to
the Company or (b) with the Company's written approval, sold with such
additional amounts applied as a credit for the Company.

Vijay Amritraj:

BY: _________________
    Vijay Amritraj:

VERTICAL COMPUTER SYSTEMS

BY: _________________
    Richard WadeEXHIBIT 10.20

                    CONSULTING AGREEMENT- TAURUS GLOBAL, LLC

* Included in Registration statement in Form S-8 filed previously filed on July
13, 2001 and incorporated by reference herein.EXHIBIT 10.21

                CONSULTING AGREEMENT - M. S. FARRELL & CO., INC.

* Included in Registration statement in Form S-8 filed previously filed on July
13, 2001 and incorporated by reference herein.<PAGE>

                                                                    EXHIBIT 10.1

                                   [FORM OF]

                             SUBSCRIPTION AGREEMENT

                            DATED AS OF JULY 27, 2001

                                 BY AND BETWEEN

                         MICROCIDE PHARMACEUTICALS, INC.

                                       AND

                                   [INVESTOR]

                 SERIES B CONVERTIBLE REDEEMABLE PREFERRED STOCK

<PAGE>

                             SUBSCRIPTION AGREEMENT

     This Subscription Agreement, dated as of July 27, 2001 (this "Agreement"),
by and between Microcide Pharmaceuticals, Inc., a Delaware corporation (the
"Company"), with headquarters located at 850 Maude Avenue, Mountain View,
California 94043, and [Investor] (the "Buyer").

                                   WITNESSETH:

     Whereas, the Company wishes to sell, and the Buyer wishes to purchase, upon
the terms and subject to the conditions of this Agreement, shares of Series B
Convertible Redeemable Preferred Stock of the Company which will be convertible
into shares of Common Stock (such capitalized term and all other capitalized
terms used in this Agreement having the respective meanings provided in Section
1);

     Now Therefore, in consideration of the premises and the mutual covenants
contained herein and other good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, the parties agree as follows:

1. Definitions.

     (a) As used in this Agreement, the terms "Agreement," "Buyer" and "Company"
shall have the respective meanings assigned to such terms in the introductory
paragraph of this Agreement.

     (b) All the agreements or instruments herein defined shall mean such
agreements or instruments as the same may from time to time be supplemented or
amended or the terms thereof waived or modified to the extent permitted by, and
in accordance with, the terms thereof and of this Agreement.

     (c) The following terms shall have the following meanings (such meanings to
be equally applicable to both the singular and plural forms of the terms
defined):

          "Affiliate" means, with respect to any Person, any other Person that
     directly, or indirectly through one or more intermediaries, controls, is
     controlled by or under common control with the subject Person. For purposes
     of the term "Affiliate," the term "control" (including the terms
     "controlling," "controlled by" and "under common control with") means the
     possession, direct or indirect, of the power to direct or to cause the
     direction of the management and policies of a Person, whether through the
     ownership of securities, by contract or otherwise. Notwithstanding the
     foregoing, neither the Company nor the Chairman of the Board of Directors
     of the Company shall be deemed to be "Affiliates" of the Buyer or any of
     the Other Buyers, or vice versa, as a result of the Voting Agreement or the
     Other Voting Agreements.

          "Aggregate Purchase Price" means the total dollar amount purchased by
     the Buyer and the Other Buyers on the Closing Date.

          "Blackout Period" means up to 20 Trading Days in any period of 365
     days commencing on the day immediately after the date the Company notifies
     the Investors that they are required, pursuant to Section 8(c)(iv), to
     suspend offers and sales of Registrable Securities pursuant to the
     Registration Statement as a result of an event or circumstance described in
     Section 8(b)(v)(A), during which period, by reason of Section 8(b)(v)(B),
     the Company is not required to amend the Registration Statement or to
     supplement the Prospectus.

          "Business Day" means any day other than a Saturday, Sunday or other
     day on which commercial banks in The City of New York are authorized or
     required by law or executive order to remain closed.

          "Certificate of Designations" means the Certificate of Designations of
     Series B Convertible Redeemable Preferred Stock in the form of ANNEX A to
     this Agreement, as the same is filed with the Secretary of State of the
     State of Delaware.

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<PAGE>

          "Claims" means any losses, claims, damages, liabilities or expenses,
     including, without limitation, reasonable fees and expenses of legal
     counsel (joint or several), incurred by a Person.

          "Closing" means 12:00 noon, California time, on a date to be mutually
     agreed upon by the parties, which shall be as soon as practicable but no
     later than the third Business Day after the satisfaction or waiver of the
     last to occur of the conditions set forth in Sections 6 and 7.

          "Closing Date" means the date on which the Closing actually occurs.

          "Code" means the Internal Revenue Code of 1986, as amended, and the
     regulations thereunder and published interpretations thereof.

          "Common Shares" means the Conversion Shares.

          "Common Stock" means the Common Stock, par value $0.001 per share, of
     the Company.

          "Conversion Notice" means the Notice of Conversion of Series B
     Convertible Redeemable Preferred Stock substantially in the form attached
     hereto as ANNEX H.

          "Conversion Price" shall have the meaning to be provided or provided
     in the Certificate of Designations.

          "Conversion Shares" means the shares of Common Stock issued or
     issuable upon conversion of the Preferred Shares.

          "ERISA" means the Employee Retirement Income Security Act of 1974, as
     amended, and the regulations thereunder and published interpretations
     thereof.

          "Financing Transaction" shall mean any transaction involving the
     issuance, sale or other disposition of (i) any capital stock of the
     Company, (ii) any option, call, warrant or right (whether or not
     immediately exercisable) to acquire any capital stock of the Company, or
     (iii) any security, instrument or obligation that is or may become
     convertible into or exchangeable for any capital stock of the Company, in
     each case where the purpose of which is to raise capital for the Company.

          "Generally Accepted Accounting Principles" for any Person means the
     United States generally accepted accounting principles and practices
     applied by such Person from time to time in the preparation of its audited
     financial statements.

          "Holders" shall have the meaning to be provided or provided in the
     Certificate of Designations.

          "Holder Optional Repurchase Event" shall have the meaning provided in
     the Certificate of Designations.

          "Indebtedness" as used in reference to any Person means all
     indebtedness of such Person for borrowed money, the deferred purchase price
     of property, goods and services and obligations under leases which are
     required to be capitalized in accordance with Generally Accepted Accounting
     Principles and shall include all such indebtedness guaranteed in any manner
     by such Person or in effect guaranteed by such Person through a contingent
     agreement to purchase and all indebtedness for the payment or purchase of
     which such Person has contingently agreed to advance or supply funds and
     all indebtedness secured by mortgage or other lien upon property owned by
     such Person, although such Person has not assumed or become liable for the
     payment of such indebtedness, and, for all purposes hereof, such
     indebtedness shall be treated as though it has been assumed by such Person
     to the extent of such guarantee (if limited in amount) or the fair market
     value of property securing such debt, as the case may be. Notwithstanding
     the foregoing, "Indebtedness" shall not include accounts payable incurred
     by the Company in the ordinary course of business consistent with past
     practice.

          "Indemnified Party" means the Company, each of its directors, each of
     its officers who signs the Registration Statement, each Person, if any, who
     controls the Company within the meaning of the 1933 Act or the 1934 Act,
     any underwriter and any other stockholder offering or selling securities

                                       2

<PAGE>

     pursuant to the Registration Statement or any of its directors or officers
     or any Person who controls such underwriter or stockholder within the
     meaning of the 1933 Act or the 1934 Act.

          "Indemnified Person" means the Buyer and each other Investor who
     beneficially owns or holds Registrable Securities included in the
     Registration Statement and each other Investor who offers or sells
     Registrable Securities included in the Registration Statement in the manner
     permitted under this Agreement, the directors, if any, of the Buyer or such
     Investor, the officers (or persons performing similar functions), if any,
     of the Buyer and any such Investor, each Person, if any, who controls the
     Buyer or any such Investor within the meaning of the 1933 Act or the 1934
     Act, any underwriter (as defined in the 1933 Act) acting on behalf of an
     Investor who participates in the offering of Registrable Securities of such
     Investor in accordance with the plan of distribution contained in the
     Prospectus, the directors, if any, of such underwriter and the officers, if
     any, of such underwriter, and each Person, if any, who controls any such
     underwriter within the meaning of the 1933 Act or the 1934 Act.

          "Inspector" means any attorney, accountant or other agent retained by
     an Investor for the purposes provided in Section 8(b)(ix).

          "Investor" or "Investors" means the Buyer and any permitted transferee
     or assignee who agrees to become bound by the provisions of Sections 5(a),
     5(b), 8, 9, and 10.

          "Majority Holders" shall have the meaning to be provided or provided
     in the Certificate of Designations.

          "Margin Stock" shall have the meaning provided in Regulation G of the
     Board of Governors of the Federal Reserve System (12 C.F.R. Part 207).

          "Merger Agreement" shall mean that certain Agreement and Plan of and
     Merger dated as of July 27, 2001 by and among the Company, California MP
     Acquisition, Inc. and Althexis.

          "Merger Shares" shall mean the shares of Common Stock issued or
     issuable pursuant to the Merger Agreement.

          "NASD" means the National Association of Securities Dealers, Inc.

          "Nasdaq" means the Nasdaq National Market.

          "Nasdaq Stock Market" means The Nasdaq Stock Market, Inc.

          "1934 Act" means the Securities Exchange Act of 1934, as amended, or
     any successor statute.

          "1933 Act" means the Securities Act of 1933, as amended, or any
     successor statute.

          "Non-Responsive Investor" means an Investor who does not provide the
     Required Information to the Company at least one Business Day prior to the
     filing of the Registration Statement.

          "Other Buyers" means each of the several holders of the Preferred
     Stock of the Company who have agreed to purchase the Preferred Stock
     pursuant to the Other Subscription Agreements.

          "Other Preferred Shares" means the shares of Preferred Stock to be
     purchased by the Other Buyers pursuant to the Other Subscription
     Agreements.

          "Other Subscription Agreements" means the several Subscription
     Agreements, dated as of the date hereof, by and between the Company and the
     several buyers named therein relating to the sale and purchase of shares of
     Preferred Stock.

          "Other Voting Agreements" means the several Voting Agreements, dated
     as of the Closing Date, by and among the Company and the Other Buyers.

                                       3

<PAGE>

          "Permitted Indebtedness" means:

               (i) Indebtedness not in excess of the aggregate principal amount
          which is outstanding on the Closing Date and which would be reflected
          on a balance sheet of the Company as of the Closing Date or in the
          notes thereto prepared in accordance with Generally Accepted
          Accounting Principles;

               (ii) Indebtedness of up to $5 million incurred after the Closing
          Date consisting of (a) equipment lease obligations or other equipment
          financings for equipment used in the business of the Company and its
          Subsidiaries which obligations or financings are required to be
          capitalized in accordance with Generally Accepted Accounting
          Principles; and (b) Indebtedness incurred in connection with
          acquisition of furniture, fixtures and equipment used in the business
          of the Company and its Subsidiaries, in each such case in an amount
          not in excess of the purchase price thereof;

               (iii) Indebtedness that is secured only by real property; and

               (iv) Indebtedness of up to $5 million that is unsecured.

          "Person" means any natural person, corporation, partnership, limited
     liability company, trust, incorporated organization, unincorporated
     association, or similar entity or any government, governmental agency or
     political subdivision.

          "Preferred Shares" means the shares of Preferred Stock to be purchased
     by the Buyer pursuant to this Agreement, as set forth on the signature page
     of this Agreement.

          "Preferred Stock" shall mean the Series B Convertible Redeemable
     Preferred Stock, par value $0.001, of the Company.

          "Prospectus" means the prospectus forming part of a Registration
     Statement at the time a Registration Statement is declared effective and
     any amendment or supplement thereto, including any documents or information
     incorporated therein by reference.

          "Purchase Price" means the aggregate purchase price for the Preferred
     Shares set forth on the signature page of this Agreement.

          "QIB" means a "qualified institutional buyer" as defined in Rule 144A.

          "Questionnaire" means the Prospective Purchaser Questionnaire
     completed by the Buyer and furnished to the Company in connection with this
     Agreement.

          "Record" shall mean all pertinent financial and other records,
     pertinent corporate documents and properties of the Company and its
     Subsidiaries subject to inspection for the purposes provided in Section
     8(b)(ix).

          "register," "registered," and "registration" refer to a registration
     effected by preparing and filing a Registration Statement or Statements in
     compliance with the 1933 Act and pursuant to Rule 415, and the declaration
     or ordering of effectiveness of such Registration Statement by the SEC.

          "Registrable Securities" means (i) the Common Shares, (ii) if the
     Common Stock is changed, converted or exchanged by the Company or its
     successor, as the case may be, into any other stock or other securities on
     or after the date the Certificate of Designations is filed with the
     Secretary of State of the State of Delaware, such other stock or other
     securities which are issued or issuable in respect of or in lieu of the
     Common Shares and (iii) if any other securities are issued to holders of
     the Common Stock (or such other shares or other securities into which or
     for which the Common Stock is so changed, converted or exchanged as
     described in the immediately preceding clause "(ii)") upon any
     reclassification, share combination, share subdivision, share dividend,
     merger, consolidation or similar transaction or event, such other
     securities which are issued or issuable in respect of or in lieu of the
     Common Shares.

          "Registration Period" means the period from the SEC Effective Date to
     the earliest of

               (i) the date that is five years after the Closing Date,

                                       4

<PAGE>

               (ii) such date after which each Investor may sell all of its
          Registrable Securities without registration under the 1933 Act
          pursuant to Rule 144, free of any limitation on the volume of such
          securities which may be sold in any period or the manner of sale, and

               (iii) the date on which the Investors no longer own or have any
          right to acquire any Registrable Securities.

          "Registration Statement" means a registration statement on Form S-3 of
     the Company under the 1933 Act, including any amendment thereto, which
     names the Investors as selling stockholders (including any documents or
     information incorporated therein by reference, whether before or after the
     SEC Effective Date).

          "Regulation D" means Regulation D under the 1933 Act.

          "Required Information" means, with respect to any Investor, all
     information regarding such Investor, the Registrable Securities held by
     such Investor or which such Investor has the right to acquire and the
     intended method of disposition of the Registrable Securities held by such
     Investor or which such Investor has the right to acquire as shall be
     required by the 1933 Act to effect the registration of the resale by such
     Investor of such Registrable Securities.

          "Rule 415" means Rule 415 under the 1933 Act or any successor rule
     providing for offering securities on a delayed or continuous basis.

          "Rule 144" means Rule 144 under the 1933 Act or any other similar rule
     or regulation of the SEC that may at any time provide a "safe harbor"
     exemption from registration under the 1933 Act so as to permit a holder of
     securities to sell such securities to the public without registration under
     the 1933 Act.

          "Rule 144A" means Rule 144A under the 1933 Act or any successor rule
     thereto.

          "SEC" means the Securities and Exchange Commission.

          "SEC Effective Date" means the date a Registration Statement is
     declared effective by the SEC.

          "SEC Filing Date" means the date a Registration Statement is first
     filed with the SEC pursuant to Section 8.

          "SEC Reports" means the (i) the 2000 10-K, (ii) the Company's
     Quarterly Reports on Form 10-Q for the quarter ended March 31, 2001 and
     (iii) the Company's definitive proxy statement for its 2001 Annual Meeting
     of Stockholders, in each case as filed with the SEC and including the
     information and documents (other than exhibits) incorporated therein by
     reference.

          "Securities" means the Shares.

          "Shares" means the Preferred Shares and the Common Shares.

          "Subsidiary" means any corporation or other entity of which a majority
     of the capital stock or other ownership interests having ordinary voting
     power to elect a majority of the board of directors or other persons
     performing similar functions are at the time directly or indirectly owned
     by the Company (including The Althexis Company, Inc. ("Althexis")).

          "Trading Day" shall have the meaning to be provided or provided in the
     Certificate of Designations.

          "Transaction Documents" means, individually or collectively, this
     Agreement, the Voting Agreement, the Certificate of Designations, the
     Transfer Agent Instruction and the other agreements, instruments and
     documents contemplated hereby and thereby.

          "Transfer Agent" means Mellon Investor Services LLC or any successor
     thereof, serving as transfer agent and registrar for the Common Stock and
     conversion agent for the Preferred Stock.

                                       5

<PAGE>

          "Transfer Agent Instruction" means the Transfer Agent Instruction from
     the Company to the Transfer Agent for the benefit of, among others, the
     Buyer and the Other Buyers, in the form of ANNEX B to this Agreement.

          "2000 10-K" means the Company's Annual Report on Form 10-K, as
     amended, for the fiscal year ended December 31, 2000.

          "Violation" means

               (i) any untrue statement or alleged untrue statement of a
          material fact contained in the Registration Statement or any
          post-effective amendment thereof or the omission or alleged omission
          to state therein a material fact required to be stated therein or
          necessary to make the statements therein not misleading,

               (ii) any untrue statement or alleged untrue statement of a
          material fact contained in the Prospectus (as amended or supplemented,
          if the Company files any amendment thereof or supplement thereto with
          the SEC) or the omission or alleged omission to state therein any
          material fact necessary to make the statements made therein, in light
          of the circumstances under which the statements therein were made, not
          misleading,

               (iii) any violation or alleged violation by the Company of the
          1933 Act, the 1934 Act, any state securities law or any rule or
          regulation under the 1933 Act, the 1934 Act or any state securities
          law, or

               (iv) any breach or alleged breach by any Person of any
          representation, warranty, covenant, agreement or other term of any of
          the Transaction Documents.

          "Voting Agreement" means that certain Voting Agreement, dated as of
     the Closing Date, by and among the Company and the Buyer.

2. Agreement to Subscribe; Purchase Price.

     (a) Subscription. Upon the terms and subject to the conditions of this
Agreement, the Buyer hereby agrees to purchase from the Company, and the Company
hereby agrees to sell to the Buyer, on the Closing Date, the number of Preferred
Shares set forth on the signature page of this Agreement, having the terms and
conditions as set forth in the Certificate of Designations in the form of ANNEX
A to this Agreement, at the price per share and for the Purchase Price set forth
on the signature page of this Agreement. The Purchase Price shall be payable in
United States Dollars.

     (b) Form of Payment. Payment by the Buyer of the Purchase Price to the
Company on the Closing Date shall be made by wire transfer of immediately
available funds to such accounts designated by the Company in writing three (3)
Business Days prior to the Closing Date.

     (c) Closing. The issuance and sale of the Preferred Shares shall occur on
the Closing Date at the offices of Cooley Godward LLP, Five Palo Alto Square,
3000 El Camino Real, Palo Alto, California. At the Closing, upon the terms and
subject to the conditions of this Agreement, (i) the Company shall issue and
deliver to the Buyer the Preferred Shares, registered in the name of the Buyer
or its nominee, against payment by the Buyer to the Company of an amount equal
to the Purchase Price, and (ii) the Buyer shall pay to the Company an amount
equal to the Purchase Price against delivery by the Company to the Buyer of the
Preferred Shares.

3. Representations, Warranties, Covenants, etc. of the Buyer.

     The Buyer represents and warrants to, and covenants and agrees with, the
Company as follows:

          (a) Acquisition for Investment. The Buyer is purchasing the Preferred
     Shares and will acquire the Common Shares for its own account for
     investment and not with a view towards the public sale or distribution
     thereof within the meaning of the 1933 Act; the Buyer will acquire any
     Common Shares for

                                       6

<PAGE>

     its own account for investment and not with a view towards distribution
     thereof within the meaning of the 1933 Act; provided, however, that
     notwithstanding the foregoing, the Buyer may sell the Common Shares
     pursuant to an effective Registration Statement or an exemption to the 1933
     Act and any state securities laws.

          (b) Accredited Investor. The Buyer is an "accredited investor" as that
     term is defined in Rule 501 of Regulation D by reason of Rule 501(a)(3)
     thereof.

          (c) Reoffers And Resales. The Buyer will not, directly or indirectly,
     offer, sell, pledge, transfer or otherwise dispose of (or solicit any
     offers to buy, purchase or otherwise acquire or take a pledge of) any of
     the Securities unless registered under the 1933 Act, pursuant to an
     exemption from registration under the 1933 Act or in a transaction not
     requiring registration under the 1933 Act.

          (d) Company Reliance. The Buyer understands that (i) the Preferred
     Shares are being offered and sold to the Buyer and (ii) upon conversion of
     the Preferred Shares, the Conversion Shares will be issued to the Buyer, in
     each such case in reliance on one or more exemptions from the registration
     requirements of the 1933 Act, including, without limitation, Regulation D,
     and exemptions from state securities laws and that the Company is relying
     upon the truth and accuracy of, and the Buyer's compliance with, the
     representations, warranties, agreements, acknowledgments and understandings
     of the Buyer set forth herein and in the Questionnaire, a true and accurate
     copy of which has been delivered by the Buyer to the Company, in order to
     determine the availability of such exemptions and the eligibility of the
     Buyer to acquire or receive an offer to acquire the Securities; and the
     information with respect to the Buyer set forth in the Questionnaire is
     accurate and complete in all material respects.

          (e) Information Provided. The Buyer and its advisors, if any, have
     requested, received and considered all information relating to the
     business, properties, operations, condition (financial or other), results
     of operations and prospects of the Company and the Subsidiaries and
     information relating to the offer and sale of the Preferred Shares and the
     offer of the Conversion Shares deemed relevant by them. The Buyer and its
     advisors, if any, have been afforded the opportunity to ask questions of
     the Company concerning the terms of the offering of the Securities and the
     business, properties, operations, condition (financial or other), results
     of operations and prospects of the Company and the Subsidiaries and have
     received satisfactory answers to any such inquiries (assuming the accuracy
     and completeness of the SEC Reports and the Company's responses to the
     Buyer's requests). Without limiting the generality of the foregoing, the
     Buyer has had the opportunity to obtain and to review the SEC Reports. In
     connection with its decision to purchase the Preferred Shares, the Buyer
     has relied solely upon the SEC Reports, the representations, warranties,
     covenants and agreements of the Company set forth in this Agreement and to
     be contained in the other Transaction Documents, as well as any
     investigation of the Company completed by the Buyer or its advisors, if
     any; and the Buyer understands that its investment in the Securities
     involves a high degree of risk.

          (f) Absence of Approvals. The Buyer understands that no United States
     federal or state agency or any other government or governmental agency has
     passed on or made any recommendation or endorsement of the Securities.

          (g) Subscription Agreement. The Buyer has all requisite power and
     authority, corporate or otherwise, to execute, deliver and perform its
     obligations under this Agreement and each of the Transaction Documents and
     the other agreements executed or to be executed by the Buyer in connection
     herewith and to consummate the transactions contemplated hereby and
     thereby. This Agreement and each of the Transaction Documents has been duly
     and validly authorized, duly executed and delivered on behalf of the Buyer
     and, assuming due execution and delivery by the Company, is a valid and
     binding agreement of the Buyer enforceable in accordance with its terms,
     except as the enforceability hereof may be limited by bankruptcy,
     insolvency, reorganization, moratorium, or other similar laws now or
     hereafter in effect relating to or affecting creditors' rights generally
     and general principles of equity, regardless of whether enforcement is
     considered in a proceeding in equity or at law.

                                       7

<PAGE>

          (h) Buyer Status. The Buyer is not a "broker" or "dealer" as those
     terms are defined in the 1934 Act which is required to be registered with
     the SEC pursuant to Section 15 of the 1934 Act.

          (i) Foreign Investors. If the Buyer is not a United States person,
     Buyer hereby represents that it is satisfied with the full observance of
     the laws of Buyer's jurisdiction in connection with the offer and sale of
     the Preferred Shares and the offer of the Conversion Shares. None of the
     transactions contemplated by this Agreement or any of the Transaction
     Documents to which it is a party will violate the laws of Buyer's
     jurisdiction.

          (j) Organization. The Buyer is a [         ] duly organized, validly
     existing and in good standing under the laws of the jurisdiction of its
     incorporation or organization.

          (k) Non-Contravention. The execution and delivery of the Transaction
     Documents by the Buyer and the consummation by the Buyer of the
     transactions contemplated by the Transaction Documents do not and will not,
     with or without the giving of notice or the lapse of time, or both, (i)
     result in any violation of any provision of the charter documents of the
     Buyer or (ii) violate or contravene any applicable law, rule or regulation
     or any applicable decree, judgment or order of any court, United States
     federal or state regulatory body, administrative agency or other
     governmental body having jurisdiction over the Buyer or any of its
     properties or assets which would have a material adverse effect on the
     Buyer or the validity or enforceability of, or the ability of the Buyer to
     perform its obligations under, the Transaction Documents.

          (l) Approvals, Filings, etc. No authorization, approval or consent of,
     or filing with, any court, governmental body, regulatory agency, self-
     regulatory organization, or stock exchange or market is required to be
     obtained or made by the Buyer for (i) the execution, delivery and
     performance of the Transaction Documents and (ii) the performance by the
     Buyer of its other obligations under the Transaction Documents.

          (m) Trading in Company Common Stock. The Buyer has not (and has not
     permitted any of its officers, directors, employees, affiliates, agents or
     representatives to): (i) effect, alone or with one or more Persons, a
     transaction or series of transactions as a means of creating actual or
     apparent active trading or raising or depressing the price of the Common
     Stock, or (ii) take any action in violation of Section 9 of the 1934 Act.

4. Representations, Warranties, Covenants, etc. of the Company.

     The Company represents and warrants to, and covenants and agrees with, the
Buyer that:

          (a) Organization and Authority. (i) The Company and each Subsidiary is
     a corporation duly organized, validly existing and in good standing under
     the laws of the jurisdiction of its incorporation, and (ii) each of the
     Company and the Subsidiaries has all requisite corporate power and
     authority to own, lease and operate its properties and to carry on its
     business as described in the SEC Reports and as currently conducted, and
     (iii) the Company has all requisite corporate power and authority to
     execute, deliver and perform its obligations under this Agreement and the
     other Transaction Documents being executed and delivered by the Company in
     connection herewith, and to consummate the transactions contemplated hereby
     and thereby. The Company has no Subsidiaries other than (i) California MP
     Acquisition, Inc. and (ii) upon consummation of the transactions
     contemplated by the Merger Agreement, Althexis.

          (b) Qualifications. The Company and each Subsidiary is duly qualified
     to do business as a foreign corporation and is in good standing in all
     jurisdictions where such qualification is necessary and where failure so to
     qualify could have a material adverse effect on the business, properties,
     operations, condition (financial or other), results of operations or
     prospects of the Company and the Subsidiaries, taken as a whole.

                                       8

<PAGE>

          (c) Capitalization.

               (i) The authorized capital stock of the Company consists of (A)
          50,000,000 shares of Common Stock, of which 11,519,313 shares were
          outstanding at the close of business on July 26, 2001 and (B)
          5,000,000 shares of preferred stock, par value $0.001, none of which
          is outstanding and of which (1) 100,000 shares are designated "Series
          A Participating Preferred Stock" and (2) [60,000] shares will be
          designated as Preferred Stock and issued pursuant to this Agreement
          and the Other Subscription Agreements. From July 27, 2001 to the
          Closing Date, other than the issuance of the Merger Shares, there will
          be (x) no material increase in the number of shares of Common Stock
          outstanding (except for shares of Common Stock issued upon exercise of
          options and warrants outstanding on the date hereof and disclosed in
          the SEC Reports) and (y) no issuance of preferred stock of the Company
          or securities convertible into, exchangeable for, or otherwise
          entitling the holder to acquire, shares of Common Stock (except for
          securities issued pursuant to the Other Subscription Agreements). The
          2000 10-K discloses as of December 31, 2000 all outstanding options or
          warrants for the purchase of, or other rights to purchase or subscribe
          for, or securities convertible into, exchangeable for, or otherwise
          entitling the holder to acquire, Common Stock or other capital stock
          of the Company, or any contracts or commitments to issue or sell
          Common Stock or other capital stock of the Company or any such
          options, warrants, rights or other securities. From December 31, 2000
          to the date hereof there has been, and to the Closing Date, other than
          the issuance of the Merger Shares, there will be, no material change
          in the amount or terms of any of the foregoing except for the grant of
          options to purchase shares of Common Stock pursuant to the Company's
          stock option plans in effect on the date of this Agreement, which
          grants are disclosed in the SEC Reports.

               (ii) The Company has duly reserved from its authorized and
          unissued shares of Common Stock the full number of shares required for
          (A) all options, warrants, convertible securities and other rights to
          acquire shares of Common Stock which are outstanding and (B) all
          shares of Common Stock and options and other rights to acquire shares
          of Common Stock which may be issued or granted under the stock option
          and similar plans which have been adopted by the Company or any
          Subsidiary. Immediately following the Closing Date, after giving
          effect to any antidilution or similar adjustment arising by reason of
          issuance of the Preferred Shares and the Other Preferred Shares and
          the other transactions contemplated by this Agreement and the Other
          Subscription Agreements, the total number of shares of Common Stock
          reserved and required to be reserved from the authorized and unissued
          shares of Common Stock for purposes of all such options, warrants,
          convertible securities, other rights and stock option and similar
          plans (excluding the Preferred Stock) will be 8,719,113 (assuming all
          Merger Shares are issued). Each outstanding class or series of
          securities for which any such antidilution adjustment will occur is
          identified on SCHEDULE 4(c) to this Agreement, together with the
          amount of such antidilution adjustment for each such class or series.
          The outstanding shares of capital stock of the Company have been duly
          authorized and validly issued and are fully paid and nonassessable and
          all of such options, warrants and other rights have been duly
          authorized by the Company. None of the holders of such outstanding
          shares of capital stock is subject to personal liability solely by
          reason of being such a holder. None of the outstanding shares of
          capital stock or options, warrants and other rights to acquire Common
          Stock has been issued in violation of the preemptive rights of any
          security holder of the Company. The offers and sales of the
          outstanding shares of capital stock of the Company and options,
          warrants and other rights to acquire Common Stock were at all relevant
          times either registered under the 1933 Act and applicable state
          securities laws or exempt from such requirements. No holder of any of
          the Company's securities has any rights, "demand," "piggy-back" or
          otherwise, to have such securities registered by reason of the
          intention to file, filing or effectiveness of the Registration
          Statement.

          (d) Concerning the Shares and the Common Stock. The Shares have been
     duly authorized and the Preferred Shares, when issued and paid for in
     accordance with this Agreement, and the Conversion Shares, when issued upon
     conversion of the Preferred Shares, in each such case will be duly and
     validly issued, fully paid and non-assessable and will not by itself
     subject the holder thereof to personal liability by

                                       9

<PAGE>

     reason of being such holder. There are no preemptive or similar rights of
     any stockholder of the Company or any other Person to acquire any of the
     Securities. The Company has duly reserved 20,000,000 shares of Common Stock
     for issuance upon conversion of the shares of Preferred Stock, and such
     shares shall remain so reserved, and the Company shall from time to time
     reserve such additional shares of Common Stock as shall be required to be
     reserved pursuant to the Certificate of Designations, so long as the
     Preferred Stock may be converted. The Common Stock is listed for trading on
     Nasdaq and (i) the Company and the Common Stock meet the criteria for
     continued listing and trading on Nasdaq; (ii) the Company has not been
     notified by the NASD or the Nasdaq Stock Market of any failure or potential
     failure to meet the criteria for continued listing and trading on Nasdaq
     and (iii) no suspension of trading in the Common Stock is in effect. The
     Company knows of no reason that the Common Shares will not be eligible for
     listing on Nasdaq.

          (e) Corporate Authorization. This Agreement and the other Transaction
     Documents have been duly and validly authorized by the Company, this
     Agreement has been duly executed and delivered by the Company and, assuming
     due execution and delivery by the Buyer, this Agreement is, and the
     Certificate of Designations, when executed by the Company and filed with
     the Secretary of State of the State of Delaware, will be, and the Transfer
     Agent Instruction, when executed and delivered by the Company, will be,
     valid and binding obligations of the Company enforceable in accordance with
     their respective terms, except as the enforceability hereof may be limited
     by bankruptcy, insolvency, reorganization, moratorium or other similar laws
     now or hereafter in effect relating to or affecting creditors' rights
     generally and general principles of equity, regardless of whether
     enforcement is considered in a proceeding in equity or at law.

          (f) Non-Contravention. The execution and delivery of the Transaction
     Documents by the Company and the consummation by the Company of the
     transactions contemplated by the Transaction Documents do not and will not,
     with or without the giving of notice or the lapse of time, or both, (i)
     result in any violation of any provision of the certificate of
     incorporation or by-laws or similar instruments of the Company or any
     Subsidiary, (ii) conflict with or result in a breach by the Company or any
     Subsidiary of any of the terms or provisions of, or constitute a default
     under, or result in the modification of, or result in the creation or
     imposition of any lien, security interest, charge or encumbrance upon any
     of the properties or assets of the Company or any Subsidiary pursuant to,
     any indenture, mortgage, deed of trust or other agreement or instrument to
     which the Company or any Subsidiary is a party or by which the Company or
     any Subsidiary or any of their respective properties or assets are bound or
     affected, in any such case which would have a material adverse effect on
     the business, properties, operations, condition (financial or other),
     results of operations or prospects of the Company and the Subsidiaries,
     taken as a whole, or the validity or enforceability of, or the ability of
     the Company to perform its obligations under, the Transaction Documents,
     (iii) violate or contravene any applicable law, rule or regulation or any
     applicable decree, judgment or order of any court, United States federal or
     state regulatory body, administrative agency or other governmental body
     having jurisdiction over the Company or any Subsidiary or any of their
     respective properties or assets which would have a material adverse effect
     on the business, properties, operations, condition (financial or other),
     results of operations or prospects of the Company and the Subsidiaries,
     taken as a whole, or the validity or enforceability of, or the ability of
     the Company to perform its obligations under, the Transaction Documents, or
     (iv) have any material adverse effect on any permit, certification,
     registration, approval, consent, license or franchise necessary for the
     Company or any Subsidiary to own or lease and operate any of its properties
     and to conduct any of its business or the ability of the Company or any
     Subsidiary to make use thereof.

          (g) Approvals, Filings, Etc. No authorization, approval or consent of,
     or filing with, any court, governmental body, regulatory agency, self-
     regulatory organization, or stock exchange or market or the stockholders of
     the Company is required to be obtained or made by the Company or any
     Subsidiary for (i) the execution, delivery and performance of the
     Transaction Documents, (ii) the issuance and sale of the Securities as
     contemplated by the Transaction Documents, and (iii) the performance by the
     Company of its other obligations under the Transaction Documents, other
     than (A) listing of the Common Shares on

                                       10

<PAGE>

     Nasdaq, (B) registration of the resale of the Common Shares under the 1933
     Act as contemplated by Section 8, (C) as may be required under applicable
     state securities or "blue sky" laws, and (D) filing of one or more Forms D
     with respect to the Securities as required under Regulation D.

          (h) Agreements.

               (i) Except for agreements or other documents filed or
          incorporated by reference as an exhibit to the SEC Reports and the
          Merger Agreement, there are no agreements, understandings,
          instruments, contracts, proposed transactions, judgments, orders,
          writs or decrees to which the Company or any Subsidiary is a party or
          to its knowledge by which it is bound which may involve (A)
          obligations (contingent or otherwise) of, or payments to, the Company
          or any Subsidiary in excess of $500,000 individually or $1,000,000 in
          the aggregate (other than obligations of, or payments to, the Company
          or any Subsidiary arising from purchase or sale agreements entered
          into in the ordinary course of business), or (B) the transfer or
          license of any patent, copyright, trade secret or other proprietary
          right to or from the Company or any Subsidiary (other than licenses
          arising from the purchase of "off the shelf" or other standard
          products), or (C) provisions restricting the development, manufacture
          or distribution of the Company's or any Subsidiary's products or
          services, or (D) indemnification by the Company or any Subsidiary with
          respect to infringements of proprietary rights (other than
          indemnification obligations arising from purchase or sale or license
          agreements entered into in the ordinary course of business).

               (ii) Neither the Company nor any Subsidiary has (A) declared or
          paid any dividends, or authorized or made any distribution upon or
          with respect to any class or series of its capital stock, (B) incurred
          or guaranteed any indebtedness for money borrowed or any other
          liabilities (other than with respect to dividend obligations,
          distributions, indebtedness and other obligations incurred in the
          ordinary course of business) individually in excess of $1,500,000 or
          in excess of $2,750,000 in the aggregate, (C) made any loans or
          advances to any person, other than ordinary advances for travel
          expenses, or (D) sold, exchanged or otherwise disposed of any of its
          assets or rights, other than the sale of its inventory in the ordinary
          course of business.

               (iii) For the purposes of subsections (i) and (ii) above, all
          indebtedness, liabilities, agreements, understandings, instruments,
          contracts and proposed transactions involving the same person or
          entity (including persons or entities the Company has reason to
          believe are affiliated therewith) shall be aggregated for the purpose
          of meeting the individual minimum dollar amounts of such subsections.

          (i) No Material Change. Except as set forth in the SEC Reports and the
     Merger Agreement (and the transactions contemplated thereby), and except
     for the transaction expressly contemplated hereby, since March 31, 2001:

               (i) there has been no material adverse change or any development
          involving a prospective material adverse change in or affecting the
          condition, financial or otherwise, or in the earnings, assets,
          business affairs or business prospects of the Company, whether or not
          arising in the ordinary course of business;

               (ii) there have been no transactions entered into by the Company
          other than those in the ordinary course of business, which are
          material with respect to the Company;

               (iii) there has been no dividend or distribution of any kind
          declared, paid or made by the Company on any class of its capital
          stock;

               (iv) there has been no damage, destruction or loss, whether or
          not covered by insurance, materially and adversely affecting the
          properties, business or prospects or financial condition of the
          Company;

               (v) there has been no waiver by the Company of a valuable right
          or of a material debt owed to it;

                                       11

<PAGE>

               (vi) there have been no direct or indirect loans made by the
          Company to any stockholder, employee, officer or director of the
          Company, other than advances made in the ordinary course of business;

               (vii) there has been no material change in any compensation
          arrangement or agreement with any employee, officer, director or
          stockholder;

               (viii) there has been no labor organization activity related to
          the Company;

               (ix) there has been no sale, assignment or transfer of any
          patents, trademarks, copyrights, trade secrets or other intangible
          assets;

               (x) there has been no change in any material agreement to which
          the Company is a party or by which it is bound which materially and
          adversely affects the business, assets, liabilities, financial
          condition, operations or prospects of the Company;

               (xi) there has been no other event or condition of any character
          that, either individually or cumulatively, has materially and
          adversely affected the business, assets, liabilities, financial
          condition, prospects or operations of the Company; or

               (xii) there has been no arrangement or commitment by the Company
          to do any of the acts described in subsections (i) through (xi) above.

          (j) SEC Filings. The Company has timely filed all reports required to
     be filed under the 1934 Act and any other material reports or documents
     required to be filed with the SEC. All of such reports and documents
     complied in all material respects, with all applicable requirements of the
     1933 Act and the 1934 Act. The Company meets the requirements for the use
     of Form S-3 for the registration of the resale of the Registrable
     Securities by the Buyer and any other Investor. The Company has not filed
     any reports with the SEC under the 1934 Act since May 18, 2001.

          (k) Absence Of Certain Proceedings. Except as disclosed in the SEC
     Reports, there is no action, suit, proceeding, inquiry or investigation
     before or by any court, public board or body, or governmental agency
     pending, or to the Company's knowledge threatened against or affecting the
     Company or any Subsidiary wherein an unfavorable decision, ruling or
     finding could have a material adverse effect on the business, properties,
     operations, condition (financial or other), results of operations or
     prospects of the Company and the Subsidiaries, taken as a whole, or the
     transactions contemplated by the Transaction Documents or which could
     adversely affect the validity or enforceability of, or the authority or
     ability of the Company to perform its obligations under, the Transaction
     Documents; and to the best of the Company's knowledge there is not pending
     or contemplated any, and there has been no, investigation by the SEC
     involving the Company or any Subsidiary or any director or officer thereof.

          (l) Liabilities. Except as and to the extent disclosed or reserved
     against in the financial statements of the Company and the notes thereto
     included in the SEC Reports, neither the Company nor any Subsidiary has any
     liability, debt or obligation, whether accrued, absolute, contingent or
     otherwise, and whether due or to become due which, individually or in the
     aggregate, are material to the Company and the Subsidiaries, taken as a
     whole. Subsequent to March 31, 2001, neither the Company nor any Subsidiary
     has incurred any liabilities, debts or obligations of any nature whatsoever
     which are, individually or in the aggregate, material to the Company and
     the Subsidiaries, taken as a whole, other than those incurred in the
     ordinary course of its business, other than as disclosed in the SEC Reports
     and other than the bridge financing referred to in Section 5.18 of the
     Merger Agreement.

          (m) Title To Properties And Assets; Liens, Etc. The Company and each
     Subsidiary has good and marketable title to their respective properties and
     assets, including the properties and assets reflected in the most recent
     balance sheet included in the SEC Reports, and good title to their
     respective leasehold estates, in each case subject to no mortgage, pledge,
     lien, lease, encumbrance or charge, other than (i) those resulting from
     taxes which have not yet become delinquent, (ii) minor liens and
     encumbrances which do not materially detract from the value of the property
     subject thereto or materially impair the operations of

                                       12

<PAGE>

     the Company or any Subsidiary, and (iii) those that have otherwise arisen
     in the ordinary course of business. All facilities, machinery, equipment,
     fixtures, vehicles and other properties owned, leased or used by the
     Company or any Subsidiary are in good operating condition and repair and
     are reasonably fit and usable for the purposes for which they are being
     used. The Company and each Subsidiary is in compliance with all material
     terms of each lease to which it is a party or is otherwise bound.

          (n) Intellectual Property.

               (i) Except as disclosed in the SEC Reports, each of the Company
          and each Subsidiary owns, or possesses adequate rights to use, all
          patents, patent rights, inventions, trade secrets, know-how,
          proprietary techniques, including processes and substances,
          trademarks, service marks, trade names and copyrights described or
          referred to in the SEC Reports or owned or used by it or which are
          necessary for the conduct of its business. Except for any documents
          filed or incorporated by reference as exhibits to the SEC Reports,
          there are no outstanding options, licenses or agreements of any kind
          relating to the foregoing proprietary rights, nor is the Company or
          any Subsidiary bound by or a party to any options, licenses or
          agreements of any kind with respect to the patents, trademarks,
          service marks, trade names, copyrights, trade secrets, licenses,
          information and other proprietary rights and processes of any other
          person or entity other than such licenses or agreements arising from
          the purchase of "off the shelf" or standard products.

               (ii) Except as disclosed in the SEC Reports, each of the Company
          and each Subsidiary has no reason to believe, and is not aware of any
          claim, that the conduct of its business will conflict with any
          patents, patent rights, inventions, trade secrets, know-how,
          proprietary techniques, including processes and substances,
          trademarks, service marks, trade names or copyrights of others.

               (iii) Neither the Company nor any Subsidiary is aware that any of
          its employee s is obligated under any contract (including licenses,
          covenants or commitments of any nature) or other agreement, or subject
          to any judgment, decree or order of any court or administrative
          agency, that would interfere with their duties to the Company or any
          Subsidiary or that would conflict with the conduct of the Company's
          business. Each former and current employee, officer and consultant of
          the Company and the Subsidiaries has executed a proprietary
          information and inventions agreement in the form(s) as delivered to
          the Buyer. No former and current employee, officer or consultant of
          the Company or any Subsidiary has excluded works or inventions made
          prior to his or her employment with the Company from his or her
          assignment of inventions pursuant to such employee, officer or
          consultant's proprietary information and inventions agreement.

               (iv) The opinions delivered pursuant to Sections 7(t) and 7(u)
          cover all of the patents and patent rights owned or used by the
          Company and the Subsidiaries.

          (o) Internal Accounting Controls. The Company maintains a system of
     internal accounting controls meeting the requirements of Section 13(b)(2)
     of the 1934 Act in all material respects.

          (p) Compliance With Laws. Neither the Company nor any Subsidiary is in
     violation of or has any liability under any statute, law, rule, regulation,
     ordinance, decision or order of any governmental agency or body or any
     court, domestic or foreign, including, without limitation, those relating
     to the use, operation, handling, transportation, disposal or release of
     hazardous or toxic substances or wastes or relating to the protection or
     restoration of the environment or human exposure to hazardous or toxic
     substances or wastes, except in the case of violations or liabilities not
     relating to the use, operation, handling, transportation, disposal or
     release of hazardous or toxic substances or wastes or relating to the
     protection or restoration of the environment or human exposure to hazardous
     or toxic substances or wastes where such violation or liability would not
     individually or in the aggregate have a material adverse effect on the
     business, properties, operations, condition (financial or other), results
     of operations or prospects of the Company and the Subsidiaries, taken as a
     whole; and neither the Company nor any Subsidiary is aware of any pending
     investigation which could lead to such a claim. No Hazardous Materials (as
     defined below) are used or have been used, stored, or disposed of by the
     Company or any Subsidiary or, to the

                                       13

<PAGE>

     Company's knowledge, by any other person or entity on any property owned,
     leased or used by the Company or any Subsidiary. For the purposes of the
     preceding sentence, "Hazardous Materials" shall mean (1) materials which
     are listed or otherwise defined as "hazardous" or "toxic" under any
     applicable local, state, federal and/or foreign laws and regulations that
     govern the existence and/or remedy of contamination on property, the
     protection of the environment from contamination, the control of hazardous
     wastes, or other activities involving hazardous substances, including
     building materials, or (2) any petroleum products or nuclear materials.

          (q) Tax Matters. The Company and each Subsidiary has filed all
     federal, state and local income and franchise tax returns required to be
     filed. All taxes shown to be due and payable on such returns, any
     assessments imposed, and to the Company's knowledge all other taxes due and
     payable by the Company and each Subsidiary on or before the Closing, have
     been paid or will be paid prior to the time they become delinquent. The
     Company has not been advised (1) that any of its returns, federal, state or
     other, have been or are being audited as of the date hereof, or (2) of any
     deficiency in assessment or proposed judgment to its or any Subsidiary's
     federal, state or other taxes. The Company has no knowledge of any
     liability of any tax to be imposed upon its or any Subsidiary's properties
     or assets as of the date of this Agreement that is not adequately provided
     for. The Company is not and has not ever been a "United States Real
     Property Holding Corporation" (a "USRPHC") as that term is defined in
     section 897(c)(2) of the Code and the Treasury Regulations thereunder (the
     "Treasury Regulations").

          (r) Investment Company. Neither the Company nor the Subsidiary is an
     "investment company" within the meaning of such term under the Investment
     Company Act of 1940, as amended, and the rules and regulations of the SEC
     thereunder.

          (s) Absence Of Brokers, Finders, Etc. No broker, finder, or similar
     Person is entitled to any commission, fee, or other compensation by reason
     of the transactions contemplated by this Agreement, and the Company shall
     pay, and indemnify and hold harmless the Buyer from, any claim made against
     the Buyer by any Person for any such commission, fee or other compensation.

          (t) No Solicitation. No form of general solicitation or general
     advertising was used by the Company or, to the best of its knowledge, any
     other Person acting on behalf of the Company, in respect of the Securities
     or in connection with the offer and sale of the Securities. Neither the
     Company nor, to its knowledge, any Person acting on behalf of the Company
     has, either directly or indirectly, sold or offered for sale to any Person
     any of the Securities or, within the six (6) months prior to the date
     hereof, any other similar security of the Company except as contemplated by
     this Agreement and the Other Subscription Agreements, and neither the
     Company nor any Person authorized to act on its behalf will sell or offer
     for sale any such security to, or solicit any offers to buy any such
     security from, or otherwise approach or negotiate in respect thereof with,
     any Person so as thereby to cause the issuance or sale of any of the
     Securities to be in violation of Section 5 of the 1933 Act.

          (u) Trading in Company Common Stock. The Company has not (and has not
     permitted any of its officers, directors, employees, affiliates, agents or
     representatives to): (i) effect, alone or with one or more Persons, a
     transaction or series of transactions as a means of creating actual or
     apparent active trading or raising or depressing the price of the Common
     Stock, or (ii) take any action in violation of Section 9 of the 1934 Act.

          (v) Rights Plan. No triggering or distribution of the rights pursuant
     to that certain Preferred Shares Rights Agreement dated as of February 2,
     1999, between the Company and ChaseMellon Shareholder Services, L.L.C. that
     would allow any holder thereof to exercise such rights shall occur as a
     result of the transactions contemplated by the Transaction Documents or the
     Merger Agreement.

          (w) Full Disclosure. The Company has provided the Buyer with all
     information requested by the Buyer in connection with its decision to
     purchase the Preferred Shares, including all information the Company
     believes is reasonably necessary to make such investment decision. Neither
     this Agreement (including each of the Company's representations and
     warranties contained in Section 4 of this

                                       14

<PAGE>

     Agreement), the exhibits hereto, the Transaction Documents nor any other
     document delivered by the Company to the Buyer or their attorneys or agents
     in connection herewith or therewith or with the transactions contemplated
     hereby or thereby, contain any untrue statement of a material fact nor,
     omit to state a material fact necessary in order to make the statements
     contained herein or therein not misleading. To the Company's knowledge,
     there are no facts which (individually or in the aggregate) materially
     adversely affect the business, assets, liabilities, financial condition,
     prospects or operations of the Company or any Subsidiary that have not been
     set forth in this Agreement, the exhibits hereto, the Transaction
     Documents, in other documents delivered to the Buyer or its attorneys or
     agents in connection herewith or in the Merger Agreement.

5. Certain Covenants And Acknowledgments.

     (a) Transfer Restrictions. Subject to the further restrictions set forth in
Section 5(o) below, the Buyer acknowledges and agrees that (i) the Preferred
Shares have not been and are not being registered under the provisions of the
1933 Act or any state securities laws and, except as provided in Section 8, the
Common Shares have not been and are not being registered under the 1933 Act or
any state securities laws, that the Preferred Shares may not be transferred
without such registration unless the Buyer receives the prior written consent of
the Company and shall have delivered to the Company an opinion of counsel,
reasonably satisfactory in form, scope and substance to the Company, to the
effect that the Preferred Shares to be transferred may be transferred without
such registration or unless transferred in accordance with Rule 144A to a QIB,
and that the Common Shares may not be transferred without such registration
unless the Buyer shall have delivered to the Company an opinion of counsel,
reasonably satisfactory in form, scope and substance to the Company, to the
effect that the Common Shares to be transferred may be transferred without such
registration or unless transferred in accordance with Rule 144A to a QIB; (ii)
no sale, assignment or other transfer of the Preferred Shares or the Common
Shares or any interest therein may be made; (iii) the Common Shares are not
transferable in the absence of registration under the 1933 Act and applicable
state securities laws, or applicable exemptions therefrom; (iv) any sale of the
Common Shares under the Registration Statement shall be made only in compliance
with the terms of this Section 5(a) and Section 8 (including, without
limitation, Section 8(c)(5)); (v) any sale of the Common Shares or, with the
prior written consent of the Company, the Preferred Shares made in reliance on
Rule 144 may be made only in accordance with the terms of said Rule and further,
if the exemption provided by Rule 144 is not available, any resale of the Common
Shares or, with the prior written consent of the Company, the Preferred Shares
under circumstances in which the seller, or the Person through whom the sale is
made, may be deemed to be an underwriter, as that term is used in the 1933 Act,
may require compliance with some other exemption under the 1933 Act or the rules
and regulations of the SEC thereunder; and (vi) the Company is under no
obligation to register the Shares (other than registration of the resale of the
Common Shares in accordance with Section 8) under the 1933 Act or, except as
provided in Sections 5(d) and 8, to comply with the terms and conditions of any
exemption thereunder. Notwithstanding the foregoing but also subject to the
further restrictions set forth in Section 5(o), no prior written consent of the
Company, registration or opinion of counsel shall be necessary for a transfer by
the Buyer to (i) its partners or former partners in accordance with partnership
interests or to any Affiliate or (ii) any other investment fund the general
partner of which is the same as the Buyer's. Notwithstanding anything expressed
or implied in any of the Transaction Documents to the contrary, subject to
applicable securities laws, nothing shall prevent the Buyer from (A) "selling
short against the box" for purposes of hedging its investment in the Preferred
Shares or (B) employing all appropriate securities or instruments in connection
with hedging transactions carried out with the intention of protecting the value
of the existing investment in the Preferred Shares.

                                       15

<PAGE>

     (b) Restrictive Legends.

          (i) The Buyer acknowledges and agrees that the certificates for the
     Preferred Shares shall bear restrictive legends in substantially the
     following form (and a stop-transfer order may be placed against transfer of
     the Preferred Shares):

               THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES
          ACT OF 1933, AS AMENDED (THE "ACT"). THE ISSUANCE TO THE HOLDER OF
          THESE SECURITIES AND THE SHARES OF COMMON STOCK ISSUABLE UPON
          CONVERSION OF THESE SECURITIES IS NOT COVERED BY A REGISTRATION
          STATEMENT UNDER THE ACT. THESE SECURITIES HAVE BEEN ACQUIRED, AND SUCH
          SHARES OF COMMON STOCK MUST BE ACQUIRED, FOR INVESTMENT AND MAY NOT BE
          SOLD, TRANSFERRED OR ASSIGNED UNLESS (A) THEIR RESALE IS REGISTERED
          UNDER THE ACT, (B) THE COMPANY HAS RECEIVED AN OPINION OF COUNSEL
          REASONABLY SATISFACTORY IN FORM, SCOPE AND SUBSTANCE TO THE COMPANY
          THAT SUCH REGISTRATION IS NOT REQUIRED OR (C) SOLD, TRANSFERRED OR
          ASSIGNED TO A QIB PURSUANT TO RULE 144A.

               EXCEPT FOR ANY TRANSFER BY THE HOLDER TO ANY INVESTMENT FUND THE
          GENERAL PARTNER OF WHICH IS THE SAME AS THE HOLDER'S AND EXCEPT AS
          PROVIDED IN SECTION 5(a) OF THE SUBSCRIPTION AGREEMENT DATED JULY 27,
          2001, THESE SECURITIES SHALL NOT BE SOLD, EXCHANGED OR OTHERWISE
          TRANSFERRED TO ANY PERSON (INCLUDING PARTNERS, AFFILIATES OR ANY OTHER
          PERSON) WITHOUT THE PRIOR WRITTEN CONSENT OF THE COMPANY.

               THESE SECURITIES ARE SUBJECT TO THE TERMS AND CONDITIONS OF A
          VOTING AGREEMENT THAT PLACES CERTAIN RESTRICTIONS ON THE VOTING OF THE
          SECURITIES. ANY PERSON ACCEPTING ANY INTEREST IN SUCH SECURITIES SHALL
          BE DEEMED TO AGREE TO AND BE BOUND BY ALL PROVISIONS OF SUCH
          AGREEMENT. A COPY OF SUCH AGREEMENT WILL BE FURNISHED TO THE RECORD
          HOLDER OF THIS CERTIFICATE WITHOUT CHARGE UPON WRITTEN REQUEST TO THE
          COMPANY AT ITS PRINCIPAL PLACE OF BUSINESS.

          (ii) The Buyer further acknowledges and agrees that until such time as
     the Common Shares have been registered for resale under the 1933 Act as
     contemplated by Section 8 or are eligible for resale under Rule 144(k)
     under the 1933 Act, the certificates for the Common Shares may bear a
     restrictive legend in substantially the following form (and a stop-transfer
     order may be placed against transfer of the certificates for the Common
     Shares):

               THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN
          REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE "ACT").
          THE SECURITIES HAVE BEEN ACQUIRED FOR INVESTMENT AND MAY NOT BE
          RESOLD, TRANSFERRED OR ASSIGNED IN THE ABSENCE OF AN EFFECTIVE
          REGISTRATION STATEMENT FOR THE SECURITIES UNDER THE ACT, OR AN OPINION
          OF COUNSEL REASONABLY SATISFACTORY IN FORM, SCOPE AND SUBSTANCE TO THE
          COMPANY THAT REGISTRATION IS NOT REQUIRED UNDER THE ACT.

          (iii) Once particular Common Shares are sold pursuant to an effective
     Registration Statement or eligible for resale pursuant to Rule 144(k) under
     the 1933 Act, thereafter (A) upon request of the Buyer (together with
     certain customary factual representations by the Buyer that the
     requirements of Rule 144(k) have been met in the case of a resale pursuant
     to Rule 144(k)) the Company will substitute certificates without
     restrictive legend for certificates for such particular Common Shares and
     remove any stop-transfer restriction relating thereto promptly, but in no
     event later than three Trading Days after surrender of such certificates by
     the Buyer and (B) the Company shall not place any restrictive legend on
     certificates for Common Shares subsequently issued or impose any stop-
     transfer restriction thereon.

                                       16

<PAGE>

     (c) Transfer Agent Instruction. Prior to the closing on the Closing Date,
the Company will (i) execute and deliver to the Transfer Agent the Transfer
Agent Instruction in substantially the form of ANNEX B to this Agreement and
pursuant thereto irrevocably instruct the Transfer Agent to issue certificates
for the Common Shares from time to time upon conversion of the Preferred Shares
in such amounts as specified from time to time to the Transfer Agent in the
Conversion Notices surrendered in connection with such conversions, (ii) appoint
the Transfer Agent the conversion agent for the Preferred Stock. The
certificates for the Common Shares will bear the restrictive legend specified in
Section 5(b) of this Agreement prior to their resale pursuant to an effective
Registration Statement or Rule 144(k) under the 1933 Act. The Common Shares
shall be registered in the name of the Buyer or its nominee and in such
denominations to be specified by the Buyer in connection with each conversion of
Preferred Shares. The Company warrants that, except as otherwise expressly
permitted by the Transfer Agent Instruction, no instruction other than (x) such
instructions referred to in this Section 5(c), (y) stop transfer instructions to
give effect to Section 5(a) hereof prior to the resale of the Common Shares
pursuant to an effective Registration Statement or Rule 144(k) under the 1933
Act and (z) the instructions required by Section 8(b)(xii) hereof will be given
by the Company to the Transfer Agent and that the Common Shares shall otherwise
be freely transferable on the books and records of the Company as and to the
extent provided in this Agreement. Nothing in this Section 5(c) shall limit in
any way the Buyer's obligations and agreement to comply with the registration
requirements of the 1933 Act or an exemption there from upon resale of the
Shares. If the Buyer provides the Company with an opinion of counsel reasonably
satisfactory in form, scope and substance to the Company that registration of a
resale by the Buyer of any of the Shares in accordance with Section 5(a) of this
Agreement is not required under the 1933 Act, the Company shall permit the
transfer of such Shares and, in the case of the Common Shares, promptly, but in
no event later than three Business Days after receipt of such opinion, instruct
the Transfer Agent to issue upon transfer one or more share certificates in such
name and in such denominations as specified by the Buyer. Nothing in this
Section 5(c) shall limit the obligations of the Company under Section 8 of this
Agreement.

     (d) Form D. The Company agrees to file with the SEC on a timely basis a
Form D with respect to the Securities as required to claim the exemption
provided by Rule 506 of Regulation D and to provide a copy thereof to the Buyer
promptly after such filing.

     (e) Nasdaq Listing; Reporting Status. Prior to the Closing Date, the
Company shall file with the Nasdaq Stock Market an application or other document
required by Nasdaq for the listing of the Common Shares with Nasdaq and shall
provide evidence of such filing to the Buyer. The Company shall use its best
efforts to obtain the listing, subject to official notice of issuance, of the
Common Shares on Nasdaq prior to the Closing Date. So long as the Buyer
beneficially owns any Preferred Shares or Common Shares, the Company shall
maintain the listing of the Common Stock on Nasdaq or a registered national
securities exchange. During the Registration Period, the Company shall timely
file all reports required to be filed with the SEC pursuant to Section 13 or
15(d) of the 1934 Act, and the Company shall not terminate its status as an
issuer required to file reports under the 1934 Act even if the 1934 Act or the
rules and regulations thereunder would permit such termination.

     (f) Use Of Proceeds. The Company acknowledges and agrees that: (i) it does
not own or have any present intention of acquiring any Margin Stock; (ii) the
proceeds of sale of the Preferred Shares will be used for general working
capital purposes and in the operation of the Company's business; (iii) none of
such proceeds will be used, directly or indirectly (A) to make any loan to or
investment in any other Person or (B) for the purpose, whether immediate,
incidental or ultimate, of purchasing or carrying any Margin Stock or for the
purpose of maintaining, reducing or retiring any indebtedness which was
originally incurred to purchase or carry any stock that is currently a Margin
Stock or for any other purpose which might constitute the transactions
contemplated by this Agreement a "purpose credit" within the meaning of
Regulation U of the Board of Governors of the Federal Reserve System; and (iv)
neither the Company nor any agent acting on its behalf has taken or will take
any action which might cause this Agreement or the transactions contemplated
hereby to violate Regulation T, Regulation U or any other regulation of the
Board of Governors of the Federal Reserve System or to violate the 1934 Act, in
each case as in effect now or as the same may hereafter be in effect.

                                       17

<PAGE>

     (g) State Securities Laws. On or before the Closing Date, the Company shall
take such action as shall be necessary to qualify, or to obtain an exemption
for, the offer and sale of the Securities to the Buyer as contemplated by the
Transaction Documents under such of the securities laws of jurisdictions in the
United States as shall be applicable thereto. In connection with the foregoing
obligations of the Company in this Section 5(g), the Company shall not be
required (i) to qualify to do business in any jurisdiction where it would not
otherwise be required to qualify but for this Section 5(g), (ii) to subject
itself to general taxation in any such jurisdiction or (iii) to file a general
consent to service of process in any such jurisdiction. The Company shall
furnish to the Buyer copies of all filings, applications, orders and grants or
confirmations of exemptions relating to such securities laws on or prior to the
Closing Date.

     (h) Limitation On Certain Actions. From the date of execution and delivery
of this Agreement by the parties hereto to the date of issuance of the Preferred
Shares, the Company (i) shall comply with Section 12 of the Certificate of
Designations as if the Preferred Shares were outstanding, (ii) shall not take
any action which, if the Preferred Shares were outstanding, would constitute a
Holder Optional Repurchase Event or, with the giving of notice or the passage of
time or both, would constitute a Holder Optional Repurchase Event and (iii)
shall not sell or otherwise issue any shares of capital stock or any other
securities (except for the Merger Shares and the granting of options in the
ordinary course of business consistent with past practice pursuant to the
Company's existing stock option, incentive or employee stock purchase plans).

     (i) Best Efforts. Each of the parties shall use its best efforts timely to
satisfy each of the conditions to the other party's obligations to sell and
purchase the Preferred Shares set forth in Section 6 or 7, as the case may be,
of this Agreement on or before the Closing Date.

     (j) Reservation Of Shares; Shares To Be Fully Paid; Listing Of Common
Stock.

          (i) The Company shall reserve and keep available, free from preemptive
     rights, out of its authorized but unissued shares of Common Stock or shares
     of Common Stock held in treasury, solely for issuance upon conversion of
     the Preferred Shares, sufficient shares to provide for the conversion of
     the Preferred Shares from time to time as Preferred Shares are converted.

          (ii) The Company shall take all action necessary to ensure that all
     shares of Common Stock issued upon conversion of the Preferred Shares will
     be fully paid and non-assessable by the Company and free from all taxes,
     liens and charges with respect to the issue thereof.

          (iii) The Company covenants that if any shares of Common Stock to be
     provided for the purpose of conversion of the Preferred Shares require
     registration with or approval of any governmental authority under any
     federal or state law before such shares may be validly issued upon
     conversion, the Company will in good faith and as expeditiously as possible
     endeavor to secure such registration or approval, as the case may be.

          (iv) The Company covenants that, so long as the Common Stock shall be
     listed on the Nasdaq, the NYSE or any other national securities exchange,
     the Company shall obtain and, so long as the Common Stock shall be so
     listed on such market or exchange, maintain approval for listing thereon of
     all Common Stock issuable upon conversion of the Preferred Shares.

     (k) Additional Covenants. From and after the date hereof, for so long as
any Preferred Shares are outstanding, the Company shall comply with the
following unless in the case of clauses (i) through (ix) (but excluding clause
(x)) otherwise agreed in writing by the Holders of outstanding shares of
Preferred Stock which shares constitute 90% of the outstanding shares of
Preferred Stock:

          (i) Limitation On Indebtedness. The Company will not itself, and will
     not permit any Subsidiary to, create, assume, incur, in any manner become
     liable in respect of, including, without limitation, by reason of any
     business combination transaction, or suffer to exist (all of which are
     referred to herein as "incurring"), any Indebtedness other than Permitted
     Indebtedness. This Section 5(k)(i) shall terminate and be of no further
     force if the closing sale price of the Common Stock exceeds $15.00 per
     share for any

                                       18

<PAGE>

     60 consecutive trading days following the date on which (A) none of the
     Conversion Shares are subject to a contractual "lock-up" restricting the
     resale thereof, (B) the Buyer is not on such date subject to any Blackout
     Period or any blackouts exist on trading in the Company's Common Stock or
     similar restrictions on sale by reason of its representative sitting on the
     Company's Board of Directors and (C) the Registration Statement is
     effective.

          (ii) Payment Of Obligations. The Company will pay and discharge, and
     will cause each Subsidiary to pay and discharge, all their respective
     material obligations and liabilities, including, without limitation, tax
     liabilities, in the ordinary course consistent with the Company's practices
     prior to the date hereof, except where the same may be contested in good
     faith by appropriate proceedings.

          (iii) Compliance With Laws. The Company will comply, and will cause
     each Subsidiary to comply with all applicable laws, ordinances, rules,
     regulations, decisions, orders and requirements of governmental authorities
     and courts (including, without limitation, environmental laws) except (A)
     where compliance therewith is contested in good faith by appropriate
     proceedings or (B) where non-compliance therewith could not reasonably be
     expected to have a material adverse effect on the business, condition
     (financial or otherwise), operations, performance, properties or prospects
     of the Company and its Subsidiaries taken as a whole.

          (iv) Investment Company Act. The Company will not be or become an
     open-end investment trust, unit investment trust or face-amount
     certificate company that is or is required to be registered under Section 8
     of the Investment Company Act of 1940, as amended, or any successor
     provision.

          (v) Limitations On Issuance Of Securities. The Company shall not (A)
     issue any security that is convertible into or otherwise entitles the
     holder to acquire Common Stock at a price that varies based on changes in
     the market price of the Common Stock, (B) issue Common Stock under any
     arrangement for re-pricing or adjusting the price after the issuance, or
     (C) issue any other preferred stock that is senior to, or at parity with,
     the Preferred Stock; provided, however, that this Section 5(k)(v) shall not
     prevent the Company from entering into an "equity line" financing
     arrangement approved by the board of directors of the Company. This Section
     5(k)(v) shall terminate and be of no further force if the closing sale
     price of the Common Stock exceeds $15.00 per share for any 60 consecutive
     trading days or such fewer number of consecutive trading days during which
     the dollar value of the trading volume over such period is greater than ten
     (10) times the Aggregate Purchase Price (provided, however, that such fewer
     number of consecutive trading days shall not be less than 30) following the
     date on which (A) none of the Conversion Shares are subject to a
     contractual "lock-up" restricting the resale thereof, (B) the Buyer is not
     on such date subject to any Blackout Period or any blackouts exist on
     trading in the Company's Common Stock or similar restrictions on sale by
     reason of its representative sitting on the Company's Board of Directors
     and (C) the Registration Statement is effective.

          (vi) Buyer's Rights of First Refusal.

               (1) Subsequent Offerings. So long as the Buyer continues to hold
          any Preferred Shares, the Buyer shall have a right of first refusal to
          purchase its pro rata share of all Equity Securities, as defined
          below, that the Company may, from time to time, propose to sell and
          issue after the date of this Agreement. The Buyer's pro rata share is
          equal to the ratio of (A) the number of shares of the Company's Common
          Stock (including all Conversion Shares) which the Buyer is deemed to
          be a holder immediately prior to the issuance of such Equity
          Securities to (B) the total number of shares of the Company's
          outstanding Common Stock (including all Conversion Shares and shares
          of Common Stock issued or issuable upon the exercise of any
          outstanding warrants, options or convertible securities) immediately
          prior to the issuance of the Equity Securities. The term "Equity
          Securities" shall mean: (A) any primary issuance of Common Stock
          registered for sale with the SEC other than shares registered with the
          SEC pursuant to a Form S-4 or Form S-8, or (B) any primary issuance of
          Common Stock issued in a transaction exempt from the registration
          requirements of the 1933 Act and subsequently registered for resale
          (either before or after closing) pursuant to Form S-1 or Form S-3

                                       19

<PAGE>

          (or any successor form) (a "PIPE") other than securities issuances in
          connection with a strategic alliance, collaboration, joint venture,
          partnership or similar arrangement of the Company with another Person
          which strategic alliance, collaboration, joint venture or partnership
          relates to the Company's business as conducted immediately prior
          thereto and which Person is engaged in a business similar or related
          to the business of the Company so long the number of shares issued in
          such transaction does not exceed ten percent of the outstanding
          capital stock of the Company (on a fully-diluted basis) immediately
          prior to the issuance. The Company shall require that the managing
          underwriter or underwriters of the Company's public offering (the
          "Offering") offer to sell to the Buyer (or its designee) its pro rata
          share of the registered Common Stock to be offered to the public, at
          the same price and on the same terms as the public, provided that the
          initial filing of the registration statement to register the Company's
          securities with the SEC (the "Filing") occurs at least 12 months after
          the signing of this Agreement (the "Grant Date"). If the Filing occurs
          within one year of the Grant Date, the Company shall offer to sell to
          the Buyer (or its designees) its pro rata share of Common Stock in a
          private placement consummated contemporaneously with the Offering (the
          "Private Placement").

               (2) Exercise of Rights. If the Company proposes to issue any
          Equity Securities, it shall give the Buyer written notice of its
          intention, describing the Equity Securities, the price and the terms
          and conditions upon which the Company proposes to issue the same. The
          Buyer shall have fifteen (15) days from the giving of such notice to
          agree to purchase its pro rata share of the Equity Securities for the
          price and upon the terms and conditions specified in the notice by
          giving written notice to the Company and stating therein the quantity
          of Equity Securities to be purchased. Notwithstanding the foregoing,
          the Company shall not be required to offer or sell such Equity
          Securities to the Buyer if it would cause the Company to be in
          violation of applicable federal securities laws by virtue of such
          offer or sale.

               (3) Termination of Rights. The rights of first refusal
          established by this Section 5(k)(vi) shall terminate and be of no
          further force if the Buyer does not purchase its pro rata share of
          Equity Securities in any subsequent offering.

          (vii) Listing Eligibility Reporting. The Company shall notify the
     Buyer from time to time within five days after the Company first learns
     that it does not meet any of the applicable requirements for the continued
     listing of the Common Stock on the principal securities market or exchange
     on which the Common Stock is listed from time to time.

          (viii) Transactions With Affiliates. The Company shall not enter into
     any transactions with any Affiliates except on terms no less favorable than
     terms that could be obtained by the Company from a third party, as
     determined in good faith by the Board of Directors of the Company.

          (ix) Rule 144A Information Requirement. Within the period prior to the
     expiration of the holding period applicable to sales of the Preferred
     Shares under Rule 144(k) under the 1933 Act (or any successor provision),
     the Company shall, during any period in which it is not subject to Section
     13 or 15(d) under the 1934 Act, make available to the Buyer which continues
     to hold Restricted Securities in connection with any sale thereof and any
     prospective purchaser of Preferred Shares from the Buyer, the information
     required pursuant to Rule 144A(d)(4) under the 1933 Act upon the request of
     the Buyer and it will take such further action as the Buyer may reasonably
     request, all to the extent required from time to time to enable the Buyer
     to sell the Preferred Shares held by it without registration under the 1933
     Act within the limitation of the exemption provided by Rule 144A, as Rule
     144A may be amended from time to time. Upon the request of the Buyer, the
     Company will deliver to the Buyer a written statement as to whether it has
     complied with such requirements.

          (x) Standstill Obligations.

               (1) The Buyer hereby agrees with the Company and covenants that
          until the first anniversary of the Closing Date (except with respect
          to clause "f." which shall continue until the second anniversary of
          the Closing Date), so long as it is the record or beneficial owner of
          any Preferred Shares (subject

                                       20

<PAGE>

          to adjustments upon stock splits, dividends and recapitalizations),
          without the prior written consent of the Company, it will not directly
          or indirectly:

                    a. make, or in any way participate in, alone or in concert
               with others, any "solicitation" of "proxies" or "consents" (as
               such terms are used in the proxy rules of the SEC promulgated
               pursuant to Section 14 of the 1934 Act) to vote for the election
               or removal of directors of the Company (except to the extent
               otherwise permitted pursuant to Section 5(k)(x)(2) below);

                    b. otherwise seek to nominate, alone or in concert with
               others, any person for election as a director of the Company who
               is not nominated by the then incumbent directors (except to the
               extent otherwise permitted pursuant to Section 5(k)(x)(2) below);

                    c. vote (whether at a meeting of stockholders, by written
               consent without a meeting or otherwise), alone or in concert with
               others, any or all of the Shares beneficially owned by the Buyer
               in favor of the election as a director of the Company of any
               nominee that has not been nominated or recommended for election
               as a director of the Company by the then incumbent directors
               (except to the extent otherwise permitted pursuant to Section
               5(k)(x)(2) below);

                    d. vote (whether at a meeting of stockholders, by written
               consent without a meeting or otherwise), alone or in concert with
               others, any or all of the Shares beneficially owned by the Buyer
               in favor of any proposal to remove as a director of the Company
               of any director that has not been made, sponsored and submitted
               by, or at the direction of, the then incumbent directors (except
               to the extent otherwise permitted pursuant to Section 5(k)(x)(2)
               below);

                    e. grant to any Person any proxy or power of attorney that
               would or could enable such Person to vote, alone or in concert
               with others, or otherwise transfer or assign to any Person the
               power to vote (whether at a meeting of stockholders, by written
               consent without a meeting or otherwise), any or all of the Shares
               beneficially owned by the Buyer in a manner that would violate
               the provisions of clauses "c." and/or "d." above or the foregoing
               prohibition on the granting of proxies and powers of attorney;

                    f. acquire, offer or propose to acquire, solicit an offer to
               sell or agree to acquire, directly or indirectly, alone or in
               concert with others, by purchase or otherwise, any direct or
               indirect "beneficial ownership" (such term, for purposes of this
               Agreement, shall have the meaning provided therefor under the
               rules and regulations promulgated by the SEC under Section 13(d)
               of the 1934) in any voting securities or any direct or indirect
               beneficial ownership in any rights, warrants or options to
               acquire, or in any securities convertible into or exchangeable
               for, any voting securities of the Company (other than as set
               forth in Section 5(k)(x)(3) and as contemplated by the
               Transaction Documents); or

                    g. otherwise act, directly or indirectly, alone or in
               concert with others to propose to the Company's stockholders any
               merger, business combination, restructuring, recapitalization or
               other transaction that, in each case, would involve or result in
               a change of control of the Company (it being understood that
               nothing in this clause "g." shall prevent any Person who is
               elected to the Board of Directors of the Company by the holders
               of the Preferred Stock pursuant to Section 12(c)(1) of the
               Certificate of Designations, in such Person's capacity as a
               member of the Board of Directors and consistent with his or her
               fiduciary duties, from individually proposing, supporting or
               voting in favor of such a transaction (whether or not such
               transaction was proposed by such Person or another member of the
               Board of Directors)).

               (2) Notwithstanding anything expressed or implied in this Section
          5(k)(x) to the contrary, the provisions of this Section 5(k)(x) shall
          not apply to, or restrict or otherwise limit in any way, (A) any right
          of any Person who is elected to the Board of Directors of the Company
          by the holders of the Preferred Stock pursuant to Section 12(c)(1) of
          the Certificate of Designations, in such Person's capacity as a member
          of the Board of Directors, to participate in the Board of Director's
          process to nominate directors for future elections in accordance with
          the Company's Certificate of Incorporation

                                       21

<PAGE>

          or (B) any right that the Buyer may have pursuant to Section 12(c)(1)
          of the Certificate of Designations to: (i) "solicit" "proxies" or
          "consents" (as such terms are used in the proxy rules of the SEC
          promulgated pursuant to Section 14 of the 1934 Act) to vote for the
          election or removal of any director who is elected to the Board of
          Directors of the Company by the holders of the Preferred Stock
          pursuant to Section 12(c)(1) of the Certificate of Designations, (ii)
          nominate any Person for election as a director who will be elected to
          the Board of Directors of the Company by the holders of the Preferred
          Stock pursuant to Section 12(c)(1) of the Certificate of Designations,
          or (iii) vote for the election or removal of any director who is
          elected to the Board of Directors of the Company by the holders of the
          Preferred Stock pursuant to Section 12(c)(1) of the Certificate of
          Designations.

               (3) Notwithstanding anything expressed or implied in this Section
          5(k)(x) to the contrary, subject to applicable securities laws,
          nothing shall prevent the Buyer from (A) "selling short against the
          box" for purposes of hedging its investment in the Preferred Shares or
          (B) employing all appropriate securities or instruments in connection
          with hedging transactions carried out with the intention of protecting
          the value of the existing investment in the Preferred Shares.

               (4) The Buyer hereby covenants and agrees that it shall not form,
          become a member of, or otherwise participate in any "group" (as
          defined in the 1934 Act) with the Other Buyers and further agrees that
          it shall take reasonable steps to ensure a sufficient number of shares
          are represented at stockholder meetings of the Company for the sole
          purpose of establishing a valid quorum.

               (5) The Buyer agrees that if the Buyer transfers any Shares in
          accordance with Section 5(a) to any Person who is not an Affiliate of
          the Buyer, then the transferee must agree to be bound by the
          provisions of this Section 5(k)(x).

     (l) USRPHC Status. The Company will not become a USRPHC at any time while
the Buyer owns any Preferred Shares or Common Stock obtained upon conversion or
exercise of the foregoing ("Covered Equity Interest"). If at any time and from
time to time the Buyer desires to sell or dispose of any Covered Equity Interest
and upon demand by the Buyer, the Company agrees to deliver to the Buyer a
letter (the "Letter") which complies with sections 1.1445-2(c)(3) and 1.897-(h)
(or any similar or successor provisions thereto) addressed to the Buyer stating
that the Company is not and has not been a USRPHC at any time during the period
beginning on the later of (i) the day five years prior to the date of the Letter
and (ii) the date of this Agreement. The Letter shall be delivered the Buyer one
business day prior to the sale of the Covered Equity Interest and shall be dated
as of such date and signed by a corporate officer under penalties of perjury in
accordance with section 1.897-2(h) of the Treasury Regulations.

     (m) No Negotiation. From the date of execution and delivery of this
Agreement by the parties hereto to the earlier to occur of (A) a termination of
this Agreement pursuant to Section 10(l) and (B) the date of issuance of the
Preferred Shares, the Company shall not (and shall not permit any of its
officers, directors, employees, affiliates, agents or representatives to)
directly or indirectly:

          (i) solicit or encourage the initiation of any inquiry, proposal or
     offer from any Person (other than the Buyer and the Other Buyers) relating
     to a possible Financing Transaction; or

          (ii) participate in any negotiations with, or provide any non-public
     information to, any Person (other than the Buyer and the Other Buyers)
     relating to or in connection with any possible Financing Transaction.

In the event that the Company receives any unsolicited inquiry, proposal or
offer from any Person (other than the Buyer or the Other Buyers) relating to a
possible Financing Transaction, the Company shall provide (i) immediate oral and
written notice to the Buyer of the receipt of any such inquiry, proposal or
offer and (ii) promptly to the Buyer copies of documentation relating to such
inquiry, proposal or offer.

     (n) No Changes To Lock-Up Agreements With Former Holders Of Common Stock Of
Althexis. From and after the date hereof, the Company shall not shorten the
length of any lock-up agreement it has with each of Mark Skaletsky, Patrick
Connelly, Michael Dailey, Paul Mass, Paul Mellett and Manuel Navia unless
otherwise agreed in writing by the Holders of 90% of outstanding shares of
Preferred Stock.

                                       22

<PAGE>

     (o) Non-Transferability Of Preferred Shares. The Buyer acknowledges and
agrees that the Preferred Shares may not be pledged or transferred unless the
Buyer receives the prior written consent of the Company. Notwithstanding the
foregoing, no prior written consent of the Company shall be necessary for a
transfer by the Buyer to any other investment fund the general partner of which
is the same as the Buyer's provided that such other investment fund agrees to
comply with the terms of the Voting Agreement and the legend requirements set
forth in Section 5(b) and, subject to applicable securities laws, nothing shall
prevent the Buyer from (i) "selling short against the box" for purposes of
hedging its investment in the Preferred Shares or (ii) employing all appropriate
securities or instruments in connection with hedging transactions carried out
with the intention of protecting the value of the existing investment in the
Preferred Shares.

6. Conditions to the Company's Obligations to Sell and Issue.

     The Buyer understands that the Company's obligations to sell to the Buyer
the Preferred Shares on the Closing Date are conditioned upon satisfaction of
the following conditions precedent on or before the Closing Date (any or all of
which may be waived by the Company in its sole discretion):

          (a) The Company shall have received a "lock-up" agreement in the form
     of ANNEX C executed by the Buyer providing that, subject to certain
     conditions, half of the Conversion Shares are subject to restrictions on
     transfer for a period of 270 days following the Closing Date;

          (b) On the Closing Date, no legal action, suit or proceeding shall be
     pending or threatened which seeks to restrain or prohibit the transactions
     contemplated by this Agreement;

          (c) The representations and warranties of the Buyer contained in this
     Agreement and in the Questionnaire shall have been true and correct on the
     date of this Agreement and shall be true and correct on the Closing Date as
     if made on and as of the Closing Date and on or before the Closing Date the
     Buyer shall have performed all covenants and agreements of the Buyer
     required to be performed by the Buyer on or before the Closing Date;

          (d) The Aggregate Purchase Price for the Preferred Shares and the
     Other Preferred Shares to be paid by the Buyer and the Other Buyers at the
     Closing shall be not less than Fifty-Five Million dollars ($55,000,000.00);

          (e) All of the conditions precedent to the merger of California MP
     Acquisition, Inc. with and into Althexis (the "Merger") pursuant to the
     Merger Agreement shall have been satisfied or waived (other than as a
     result of any failure on the part of the Company to comply with or perform
     any covenant or obligation set forth in the Merger Agreement); and

          (f) The Company shall have received a Voting Agreement in the form of
     ANNEX F executed by the Buyer.

7. Conditions to the Buyer's Obligations to Purchase.

     The Company understands that the Buyer's obligations to purchase from the
Company the Preferred Shares on the Closing Date are conditioned upon
satisfaction of the following conditions precedent on or before the Closing Date
(any or all of which may be waived by the Buyer in its sole discretion):

          (a) The Transfer Agent shall have acknowledged in writing its receipt
     and acceptance of the Transfer Agent Instruction in substantially the form
     of ANNEX B to this Agreement and the Buyer shall have received evidence of
     such receipt and acknowledgment;

          (b) The Aggregate Purchase Price for the Preferred Shares and the
     Other Preferred Shares to be paid by the Buyer and the Other Buyers at the
     Closing shall be not less than Fifty-Five Million dollars ($55,000,000.00);

          (c) On the Closing Date, no legal action, suit or proceeding shall be
     pending or threatened which (i) seeks to restrain or prohibit the
     transactions contemplated by this Agreement, (ii) could have a material

                                       23

<PAGE>

     adverse effect on the business, properties, operations, condition
     (financial or other), results of operations or prospects of the Company or
     (iii) could have a material adverse effect on the business, properties,
     operations, condition (financial or other), results of operations or
     prospects of Althexis;

          (d) The representations and warranties of the Company contained in
     this Agreement and each other agreement or instrument executed and
     delivered by the Company in connection with this Agreement shall have been
     true and correct on the date of this Agreement and shall be true and
     correct on the Closing Date as if made on the Closing Date; and on or
     before the Closing Date the Company shall have performed all covenants and
     agreements of the Company contained herein or therein and required to be
     performed by the Company on or before the Closing Date;

          (e) No event which, if the Preferred Shares were outstanding, would
     constitute a Holder Optional Repurchase Event or, with the giving of notice
     or the lapse of time, or both, would constitute a Holder Optional
     Repurchase Event shall have occurred and be continuing;

          (f) The Company shall have closed the Merger pursuant to the Merger
     Agreement;

          (g) Mark Skaletsky shall have been elected to the Board of Directors
     of the Company as of the effective time of the Merger and appointed Chief
     Executive Officer of the Company as of the effective time of the Merger;

          (h) The Company shall have taken all necessary corporate action, if
     any, to amend the Company's Certificate of Incorporation to (i) reflect the
     transactions contemplated by the Transaction Documents (including the
     voting provisions of the Certificate of Designations), (ii) set the
     authorized number of members of the Board of Directors at eight (8)
     (including a provision that shall prevent the Company from increasing the
     authorized size of the Board of Directors unless it receives the prior
     written consent of the Majority Holders) and (iii) provide for a procedure
     to nominate directors in future elections to provide that the directors
     elected pursuant to Section 12(c)(1) of the Certificate of Designations
     shall have the right to consent to one of such future nominees;

          (i) The Company shall have delivered to the Buyer a certificate, dated
     the Closing Date, duly executed by its Chief Executive Officer or Chief
     Financial Officer to the effect set forth in subparagraphs "(b)," "(c),"
     "(d)," "(e)," "(f)," "(g)" and "(h)" of this Section 7;

          (j) The Company shall have received "lock-up" agreements in the form
     of ANNEX D-1 executed by Mark Skaletsky, Patrick Connelly, Paul Mellett and
     Manuel Navia and in the form of ANNEX D-2 executed by Michael Dailey and
     Paul Mass providing that, subject to certain conditions, all of the shares
     of Common Stock held by such holders are subject to restrictions on
     transfer for a period of at least of 365 days following the Closing Date;

          (k) The Transaction Documents and the transactions contemplated
     thereby shall have been approved by the stockholders of the Company by the
     required vote;

          (l) The Company shall have received a waiver from any officer or
     director of the Company who would be entitled to have the vesting schedule
     of any outstanding options accelerate as a result of the Merger or the
     transactions contemplated by the Transaction Agreements, either alone or
     together, waiving any right to such acceleration;

          (m) The authorized size of the Board of Directors of the Company shall
     be eight (8) persons;

          (n) The Company shall have taken all necessary corporate action such
     that immediately following the Closing, the directors of the Company shall
     include David Schnell, Charles Newhall, Kate Bingham, Mark Skaletsky, John
     Walker and James Rurka;

          (o) The Buyer shall have received satisfactory confirmation of the
     filing with the Secretary of State of the State of Delaware of the
     Certificate of Designations;

          (p) The Conversion Shares shall have been duly authorized and
     reserved;

                                       24

<PAGE>

          (q) The Company shall have filed a Notification Form for Listing of
     Additional Shares with respect to the Common Shares with Nasdaq;

          (r) The Company shall have delivered to the Buyer a certificate, dated
     the Closing Date, of the Secretary of the Company certifying (i) the
     Certificate of Incorporation and bylaws of the Company as in effect on the
     Closing Date, (ii) all resolutions of the Board of Directors (and
     committees thereof) of the Company relating to this Agreement and the
     transactions contemplated hereby and (iii) such other matters as reasonably
     requested by the Buyer;

          (s) The Buyer shall have received on the Closing Date an opinion of
     Bingham Dana LLP, counsel for the Company, dated the Closing Date,
     addressed to the Buyer, in form, scope and substance reasonably
     satisfactory to the Buyer, substantially in the form of ANNEX E to this
     Agreement;

          (t) The Buyer shall have received on the Closing Date, an opinion of
     intellectual property counsel for the Company reasonably satisfactory to
     the Buyer, dated the Closing Date, addressed to the Buyer, in form, scope
     and substance reasonably satisfactory to the Buyer;

          (u) The Buyer shall have received on the Closing Date, an opinion of
     intellectual property counsel for Althexis reasonably satisfactory to the
     Buyer, dated the Closing Date, addressed to the Buyer, in form, scope and
     substance reasonably satisfactory to the Buyer; and

          (v) On the Closing Date, (i) trading in securities on the New York
     Stock Exchange, Inc., the American Stock Exchange, Inc. or Nasdaq shall not
     have been suspended or materially limited and (ii) a general moratorium on
     commercial banking activities in the State of New York shall not have been
     declared by either federal or state authorities.

8. Registration Rights.

     (a) Mandatory Registration.

          (i) The Company shall prepare promptly and, on or prior to the date
     which is 30 days after the Closing Date, file with the SEC the Registration
     Statement covering the Registrable Securities which covers the resale by
     the Buyer or any of the Buyer's distributees of (A) a number of shares of
     Common Stock equal to at least the number of Common Shares issuable to the
     Buyer upon conversion of the Preferred Shares, determined at the Conversion
     Price which is applicable on the day the Registration Statement is filed
     with the SEC as Registrable Securities, and which Registration Statement
     shall state that, in accordance with Rule 416 under the 1933 Act, such
     Registration Statement also covers such indeterminate number of additional
     shares of Common Stock as may become issuable upon conversion of the
     Preferred Shares to prevent dilution resulting from stock splits, stock
     dividends or other dilutive events for which anti-dilution protection is
     provided in the Certificate of Designations.

          (ii) Prior to the SEC Effective Date for the Registration Statement,
     the Company will not, without the prior written consent of the Majority
     Holders, file or request the acceleration of any other registration
     statement filed with the SEC, and during any time subsequent to the SEC
     Effective Date when the Registration Statement for any reason is not
     available for use by any Investor for the resale of any Registrable
     Securities, the Company shall not file any other registration statement or
     any amendment thereto with the SEC under the 1933 Act or request the
     acceleration of the effectiveness of any other registration statement
     previously filed with the SEC, other than (A) any registration statement on
     Form S-8 and (B) any registration statement or amendment which the Company
     is required to file or as to which the Company is required to request
     acceleration pursuant to any obligation in effect on the date of execution
     and delivery of this Agreement.

                                       25

<PAGE>

     (b) Obligations of the Company. In connection with the registration of the
Registrable Securities, the Company shall:

          (i) use its best efforts to cause the Registration Statement to become
     effective as promptly as possible after the filing thereof and to keep the
     Registration Statement effective pursuant to Rule 415 at all times during
     the Registration Period. The Company shall submit to the SEC, within three
     Business Days after the Company learns that no review of the Registration
     Statement will be made by the staff of the SEC or that the staff of the SEC
     has no further comments on the Registration Statement a request for
     acceleration of effectiveness of the Registration Statement to a time and
     date not later than 48 hours after the submission of such request. The
     Company shall notify the Investors of the effectiveness of the Registration
     Statement on the SEC Effective Date. The Company represents and warrants
     and covenants to the Investors that (A) the Registration Statement
     (including any amendments thereto and prospectuses contained therein), at
     the time it is first filed with the SEC, at the time it is ordered
     effective by the SEC and at all times during which it is required to be
     effective hereunder (and each such amendment at the time it is filed with
     the SEC and at all times during which it is available for use in connection
     with the offer and sale of the Registrable Securities) shall not contain
     any untrue statement of a material fact or omit to state a material fact
     required to be stated therein or necessary to make the statements therein
     not misleading and (B) the Prospectus (including any supplements thereto)
     at the time the Registration Statement is declared effective by the SEC and
     at all times that the Prospectus is required by this Agreement to be
     available for use by any Investor and, in accordance with Section 8(c)(iv),
     any Investor is entitled to sell Registrable Securities pursuant to the
     Prospectus (and each such supplement at the time it is filed with the SEC
     and at all times during which it is available for use in connection with
     the offer and sale of the Registrable Securities), shall not contain any
     untrue statement of a material fact or omit to state a material fact
     required to be stated therein, or necessary to make the statements therein,
     in light of the circumstances in which they were made, not misleading;

          (ii) subject to Section 8(b)(v), prepare and file with the SEC such
     amendments (including post-effective amendments) and supplements to the
     Registration Statement and the Prospectus as may be necessary to keep the
     Registration Statement effective, and the Prospectus current, at all times
     during the Registration Period, and, during the Registration Period, comply
     with the provisions of the 1933 Act applicable to the Company in order to
     permit the disposition by the Investors of all Registrable Securities
     covered by the Registration Statement;

          (iii) furnish to each Investor whose Registrable Securities are
     included in the Registration Statement and its legal counsel (A) promptly
     after the same is prepared and publicly distributed, filed with the SEC or
     received by the Company, five copies of the Registration Statement and any
     amendment thereto and the Prospectus and each amendment or supplement
     thereto, (B) one copy of each letter written by or on behalf of the Company
     to the SEC or the staff of the SEC and each item of correspondence from the
     SEC or the staff of the SEC relating to the Registration Statement (other
     than any portion of any thereof which contains information for which the
     Company has sought confidential treatment), each of which the Company
     hereby determines to be confidential information and which the Buyer hereby
     agrees to keep confidential as a confidential Record in accordance with
     Section 8(b)(ix) and (C) such number of copies of the Prospectus and all
     amendments and supplements thereto and such other documents, as such
     Investor may reasonably request in order to facilitate the disposition of
     the Registrable Securities owned by such Investor;

          (iv) subject to Section 8(b)(v), use its best efforts (A) to register
     and qualify the Registrable Securities covered by the Registration
     Statement under the securities or blue sky laws of such jurisdictions as
     the Investors who hold a majority in interest of the Registrable Securities
     reasonably request, (B) to prepare and to file in those jurisdictions such
     amendments (including post-effective amendments) and supplements to such
     registrations and qualifications as may be necessary to maintain the
     effectiveness thereof at all times during the Registration Period and (C)
     to take all other actions reasonably necessary or advisable to qualify the
     Registrable Securities for sale by the Investors in such jurisdictions;
     provided, however, that the Company shall not be required in connection
     therewith or as a condition thereto (I) to

                                       26

<PAGE>

     qualify to do business in any jurisdiction where it would not otherwise be
     required to qualify but for this Section 8(b)(iv), (II) to subject itself
     to general taxation in any such jurisdiction or (III) to file a general
     consent to service of process in any such jurisdiction;

          (v) (A) as promptly as practicable after becoming aware of such event
     or circumstance, notify each Investor of the occurrence of an event or
     circumstance of which the Company has knowledge (x) as a result of which
     the Prospectus, as then in effect, includes an untrue statement of a
     material fact or omits to state a material fact required to be stated
     therein or necessary to make the statements therein, in light of the
     circumstances under which they were made, not misleading or (y) which
     requires the Company to amend or supplement the Registration Statement due
     to the receipt from an Investor of new or additional information about such
     Investor or its intended plan of distribution of its Registrable
     Securities, and use its best efforts promptly to prepare a supplement or
     amendment to the Registration Statement and Prospectus to correct such
     untrue statement or omission or to add any new or additional information,
     and deliver a number of copies of such supplement or amendment to each
     Investor as such Investor may reasonably request; (B) notwithstanding
     Section 8(b)(v)(A) above, if at any time the Company notifies the Investors
     as contemplated by Section 8(b)(v)(A) the Company also notifies the
     Investors that the event giving rise to such notice relates to a
     development involving the Company which occurred subsequent to the later of
     (x) the SEC Effective Date and (y) the latest date prior to such notice on
     which the Company has amended or supplemented the Registration Statement,
     then the Company shall not be required to use best efforts to make such
     amendment during a Blackout Period; provided, however, that no Blackout
     Period may exceed 20 Trading Days (whether or not consecutive) in any
     period of 365 consecutive days; and provided further, however, that no
     Blackout Period may commence sooner than 90 days after the end of an
     earlier Blackout Period;

          (vi) as promptly as practicable after becoming aware of such event,
     notify each Investor who holds Registrable Securities being offered or sold
     pursuant to the Registration Statement of the issuance by the SEC of any
     stop order or other suspension of effectiveness of the Registration
     Statement at the earliest possible time;

          (vii) permit the Investors who hold Registrable Securities being
     included in the Registration Statement, at such Investors' sole cost and
     expense (except as otherwise specifically provided in Section 10(k)) to
     review and have a reasonable opportunity to comment on the Registration
     Statement and all amendments and supplements thereto at least five (5)
     Business Days prior to their filing with the SEC and shall not file any
     such document to which any Investor reasonably objects;

          (viii) make generally available to its security holders as soon as
     practical, but not later than 90 days after the close of the period covered
     thereby, an earnings statement (in form complying with the provisions of
     Rule 158 under the 1933 Act) covering a 12-month period beginning not later
     than the first day of the Company's fiscal quarter next following the SEC
     Effective Date;

          (ix) make available for inspection by any Investor and any Inspector
     retained by such Investor, at such Investor's sole expense, all Records as
     shall be reasonably necessary to enable such Investor to exercise its due
     diligence responsibility, and cause the Company's and the Subsidiaries'
     officers, directors and employees to supply all information which such
     Investor or any Inspector may reasonably request for purposes of such due
     diligence; provided, however, that such Investor shall hold in confidence
     and shall not make any disclosure of any Record or other information which
     the Company determines in good faith to be confidential, and of which
     determination such Investor is so notified at the time such Investor
     receives such information, unless (A) the disclosure of such Record is
     necessary to avoid or correct a misstatement or omission in the
     Registration Statement, (B) the release of such Record is ordered pursuant
     to a subpoena or other order from a court or governmental body of competent
     jurisdiction or (C) the information in such Record has been made generally
     available to the public other than by disclosure in violation of this or
     any other agreement. The Company shall not be required to disclose any
     confidential information in such Records to any Inspector until and unless
     such Inspector shall have entered into a confidentiality agreement with the
     Company with respect thereto, substantially in the form of this

                                       27

<PAGE>

     Section 8(b)(ix), which agreement shall permit such Inspector to disclose
     Records to the Investor who has retained such Inspector. Each Investor
     agrees that it shall, upon learning that disclosure of such Records is
     sought in or by a court or governmental body of competent jurisdiction or
     through other means, give prompt notice to the Company and allow the
     Company, at the Company's expense, to undertake appropriate action to
     prevent disclosure of, or to obtain a protective order for, the Records
     deemed confidential. The Company shall hold in confidence and shall not
     make any disclosure of information concerning an Investor provided to the
     Company pursuant to this Agreement unless (A) disclosure of such
     information is necessary to comply with federal or state securities laws,
     (B) disclosure of such information is necessary to avoid or correct a
     misstatement or omission in the Registration Statement, (C) release of such
     information is ordered pursuant to a subpoena or other order from a court
     or governmental body of competent jurisdiction, or (D) such information has
     been made generally available to the public other than by disclosure in
     violation of this or any other agreement. The Company agrees that it shall,
     upon learning that disclosure of such information concerning an Investor is
     sought in or by a court or governmental body of competent jurisdiction or
     through other means, give prompt notice to such Investor and allow such
     Investor, at such Investor's expense, to undertake appropriate action to
     prevent disclosure of, or to obtain a protective order for, such
     information;

          (x) use its best efforts to cause all the Registrable Securities
     covered by the Registration Statement as of the SEC Effective Date to be
     listed on Nasdaq or such other principal securities market on which
     securities of the same class or series issued by the Company are then
     listed or traded;

          (xi) provide a transfer agent and registrar, which may be a single
     entity, for the Registrable Securities at all times;

          (xii) cooperate with the Investors who hold Registrable Securities
     being offered pursuant to the Registration Statement to facilitate the
     timely preparation and delivery of certificates (not bearing any
     restrictive legends) representing Registrable Securities to be offered
     pursuant to the Registration Statement and enable such certificates to be
     in such denominations or amounts as the Investors may reasonably request
     and registered in such names as the Investors may request; and, not later
     than the SEC Effective Date and after the resale of the Registrable
     Securities pursuant to an effective Registration Statement, the Company
     shall deliver (A) to the Transfer Agent (with copies to the Investors whose
     Registrable Securities are included in the Registration Statement) an
     instruction to remove any legends on previously issued Registrable
     Securities and thereafter to issue Registrable Securities without any
     legends and (B) shall cause legal counsel selected by the Company to
     deliver to the Investors whose Registrable Securities are included in the
     Registration Statement and, if required by the Transfer Agent, to the
     Transfer Agent an opinion of counsel to permit such legend removal;

          (xiii) during the Registration Period, the Company shall not bid for
     or purchase any Common Stock or any right to purchase Common Stock or
     attempt to induce any Person to purchase any such security or right if such
     bid, purchase or attempt would in any way limit the right of the Investors
     to sell Registrable Securities by reason of the limitations set forth in
     Regulation M under the 1934 Act; and

          (xiv) take all other reasonable actions necessary to expedite and
     facilitate disposition by the Investors of the Registrable Securities
     pursuant to the Registration Statement.

     (c) Obligations Of The Buyer And Other Investors. In connection with the
registration of the Registrable Securities, the Investors shall have the
following obligations:

          (i) It shall be a condition precedent to the obligations of the
     Company to complete the registration pursuant to this Agreement with
     respect to the Registrable Securities of a particular Investor that such
     Investor shall furnish to the Company the Required Information and shall
     execute such documents in connection with such registration as the Company
     may reasonably request. At least ten (10) Business Days prior to the first
     anticipated filing date of the Registration Statement, the Company shall
     notify each Investor of the Required Information if any of such Investor's
     Registrable Securities are eligible for inclusion in the Registration
     Statement. If at least one Business Day prior to the SEC Filing Date the

                                       28

<PAGE>

     Company has not received the Required Information from an Investor, then
     the Company may file the Registration Statement without including
     Registrable Securities of such Non-Responsive Investor; provided, however,
     that nothing herein shall relieve the Company of its obligation to register
     the resale of such Investor's Registrable Securities promptly after such
     Investor provides the Required Information to the Company;

          (ii) Each Investor by such Investor's acceptance of the Registrable
     Securities agrees to cooperate with the Company as reasonably requested by
     the Company in connection with the preparation and filing of the
     Registration Statement hereunder, unless such Investor has notified the
     Company of such Investor's election to exclude all of such Investor's
     Registrable Securities from the Registration Statement;

          (iii) Each Investor agrees that it will not effect any disposition of
     the Registrable Securities except as contemplated in the Registration
     Statement or as shall otherwise be in compliance with applicable securities
     laws and that it will promptly notify the Company of any material changes
     in the information set forth in the Registration Statement regarding such
     Investor or its plan of distribution; each Investor agrees (A) to notify
     the Company in the event that such Investor enters into any material
     agreement with a broker or a dealer for the sale of the Registrable
     Securities through a block trade, special offering, exchange distribution
     or a purchase by a broker or dealer and (B) in connection with such
     agreement, to provide to the Company in writing the information necessary
     to prepare any supplemental prospectus pursuant to Rule 424(c) under the
     1933 Act which is required with respect to such transaction;

          (iv) Each Investor acknowledges that there may occasionally be times
     as specified in Section 8(b)(v) or 8(b)(vi) when the Company must suspend
     the use of the Prospectus until such time as an amendment to the
     Registration Statement has been filed by the Company and declared effective
     by the SEC, the Company has prepared a supplement to the Prospectus or the
     Company has filed an appropriate report with the SEC pursuant to the 1934
     Act. Each Investor hereby covenants that it will not sell any Registrable
     Securities pursuant to the Prospectus during the period commencing at the
     time at which the Company gives such Investor notice of the suspension of
     the use of the Prospectus in accordance with Section 8(b)(v) or 8(b)(vi)
     and ending at the time the Company gives such Investor notice that such
     Investor may thereafter effect sales pursuant to the Prospectus, or until
     the Company delivers to such Investor an amended or supplemented
     Prospectus;

          (v) In connection with any sale of Registrable Securities which is
     made by an Investor pursuant to the Registration Statement (A) if such sale
     is made through a broker, such Investor shall instruct such broker to
     deliver the Prospectus (including any amendments or supplements thereto) to
     the purchaser (or the broker therefor) in connection with such sale, shall
     supply copies of the Prospectus (including any amendments or supplements
     thereto) to such broker, (B) if such sale is made in a transaction directly
     with a purchaser and not through the facilities of any securities exchange
     or market, such Investor shall deliver, or cause to be delivered, the
     Prospectus to such purchaser; and (C) if such sale is made by any means
     other than those described in the immediately preceding clauses (A) and
     (B), such Investor shall otherwise use its reasonable best efforts to
     comply with the prospectus delivery requirements of the 1933 Act applicable
     to such sale; and

          (vi) Each Investor agrees to notify the Company promptly after the
     event of the completion of the sale by such Investor of all Registrable
     Securities to be sold by such Investor pursuant to the Registration
     Statement.

     (d) Rule 144. With a view to making available to each Investor the benefits
of Rule 144, the Company agrees:

          (i) so long as each Investor owns or has the right to acquire
     Registrable Securities, promptly upon request, furnish to such Investor
     such information as may be necessary, and otherwise reasonably to cooperate
     with such Investor, to permit such Investor to sell its Registrable
     Securities pursuant to Rule 144 without registration; and

                                       29

<PAGE>

          (ii) if at any time the Company is not required to file such reports
     with the SEC under Sections 13 or 15(d) of the 1934 Act, to use its best
     efforts to, upon the request of an Investor, make publicly available other
     information so long as is necessary to permit publication by brokers and
     dealers of quotations for the Common Stock and sales of the Registrable
     Securities in accordance with Rule 15c2-11 under the 1934 Act.

9. Indemnification And Contribution.

     (a) Indemnification.

          (i) To the extent not prohibited by applicable law, the Company will
     indemnify and hold harmless each Indemnified Person against any Claims to
     which any of them may become subject under the 1933 Act, the 1934 Act or
     otherwise, insofar as such Claims (or actions or proceedings, whether
     commenced or threatened, in respect thereof) arise out of or are based upon
     any Violation or any of the transactions contemplated by the Transaction
     Documents. Subject to the restrictions set forth in Section 9(a)(iii) with
     respect to the number of legal counsel, the Company shall reimburse each
     Indemnified Person, promptly as such expenses are incurred and are due and
     payable, for any legal fees or other expenses incurred by them in
     connection with investigating or defending any such Claim. Notwithstanding
     anything to the contrary contained herein, an Indemnified Person shall not
     be entitled to indemnification under this Section 9(a)(i) for: (A) a Claim
     arising out of or based upon a Violation which occurs in reliance upon and
     in conformity with information relating to an Indemnified Person furnished
     in writing to the Company by such Indemnified Person or underwriter for
     such Indemnified Person expressly for use in connection with the
     preparation of the Registration Statement or any such amendment thereof or
     supplement thereto if the Prospectus or such amendment or supplement
     thereto was timely made available by the Company pursuant to Section
     8(b)(iii); and (B) amounts paid in settlement of any Claim if such
     settlement is effected without the prior written consent of the Company,
     which consent shall not be unreasonably withheld. Such indemnity shall
     remain in full force and effect regardless of any investigation made by or
     on behalf of the Indemnified Person and shall survive the transfer of the
     Registrable Securities by the Investors.

          (ii) In connection with the Registration Statement, each Investor
     whose Registrable Securities are included in the Registration Statement
     agrees to indemnify and hold harmless, to the same extent and in the same
     manner set forth in Section 9(a)(i), each Indemnified Party against any
     Claim to which any of them may become subject, under the 1933 Act, the 1934
     Act or otherwise, insofar as such Claim arises out of or is based upon any
     Violation, in each case to the extent (and only to the extent) that such
     Violation occurs in reliance upon and in conformity with written
     information furnished to the Company by such Investor expressly for use in
     connection with the Registration Statement; and such Investor will
     reimburse any legal or other expenses reasonably incurred by them in
     connection with investigating or defending any such Claim; provided,
     however, that the indemnity agreement contained in this Section 9(a)(ii)
     shall not apply to amounts paid in settlement of any Claim if such
     settlement is effected without the prior written consent of such Investor,
     which consent shall not be unreasonably withheld; provided, further,
     however, that the Investor shall be liable under this Section 9(a)(ii) for
     only that amount of all Claims in the aggregate as does not exceed the
     amount by which the proceeds to such Investor as a result of the sale of
     Registrable Securities pursuant to the Registration Statement exceeds the
     amount paid by such Investor for such Registrable Securities. Such
     indemnity shall remain in full force and effect regardless of any
     investigation made by or on behalf of such Indemnified Party and shall
     survive the transfer of the Registrable Securities by the Investors.

          (iii) Promptly after receipt by an Indemnified Person or Indemnified
     Party under this Section 9(a) of notice of the commencement of any action
     (including any governmental action), such Indemnified Person or Indemnified
     Party shall, if a Claim in respect thereof is to be made against any
     indemnifying party under this Section 9(a), deliver to the indemnifying
     party a notice of the commencement thereof and the indemnifying party shall
     have the right to participate in, and, to the extent the indemnifying party
     so desires, jointly with any other indemnifying party similarly noticed, to
     assume control of the defense

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<PAGE>

     thereof with counsel reasonably satisfactory to the Indemnified Person or
     the Indemnified Party, as the case may be; provided, however, that an
     Indemnified Person or Indemnified Party shall have the right to retain its
     own counsel with the fees and expenses to be paid by the indemnifying
     party, if, in the opinion of the indemnified party (upon advice of
     counsel), the representation by such counsel of the Indemnified Person or
     Indemnified Party and the indemnifying party would be inappropriate due to
     actual or potential differing interests between such Indemnified Person or
     Indemnified Party and any other party represented by such counsel in such
     proceeding; provided further, however, that no indemnifying person shall be
     responsible for the fees and expenses of more than one separate counsel for
     all Indemnified Persons or Indemnified Parties, as the case may be,
     hereunder and one separate counsel in each jurisdiction in which a Claim is
     pending or threatened. The failure to deliver notice to the indemnifying
     party within a reasonable time of the commencement of any such action shall
     not relieve such indemnifying party of any liability to the Indemnified
     Person or Indemnified Party under this Section 9(a), except to the extent
     that the indemnifying party is materially prejudiced in its ability to
     defend such action. The indemnification required by this Section 9(a) shall
     be made by periodic payments of the amount thereof during the course of the
     investigation or defense, as such expense, loss, damage or liability is
     incurred and is due and payable.

     (b) Contribution. To the extent any indemnification by an indemnifying
party as set forth in Section 9(a) above is applicable by its terms but is
prohibited or limited by law, the indemnifying party agrees to make the maximum
contribution with respect to any amounts for which it would otherwise be liable
under Section 9(a) to the fullest extent permitted by law. In determining the
amount of contribution to which the respective parties are entitled, there shall
be considered the relative fault of each party, the parties' relative knowledge
of and access to information concerning the matter with respect to which the
Claim was asserted, the opportunity to correct and prevent any statement or
omission and any other equitable considerations appropriate under the
circumstances; provided, however, that (i) no contribution shall be made under
circumstances where the maker would not have been liable for indemnification
under the fault standards set forth in Section 9(a), (ii) no Person guilty of
fraudulent misrepresentation (within the meaning of Section 11(f) of the 1933
Act) shall be entitled to contribution from any other Person who was not guilty
of such fraudulent misrepresentation and (iii) the contribution by any Investor
in respect of all Claims in the aggregate shall be limited to the amount by
which the proceeds received by such seller from the sale of such Registrable
Securities exceeds the amount paid by such Investor for such Registrable
Securities.

     (c) Other Rights. The indemnification and contribution provided in this
Section 9 shall be in addition to any other rights and remedies available at law
or in equity.

10. Miscellaneous.

     (a) Governing Law. This Agreement shall be governed by and interpreted in
accordance with the laws of the State of California.

     (b) Headings. The headings, captions and footers of this Agreement are for
convenience of reference and shall not form part of, or affect the
interpretation of, this Agreement.

     (c) Severability. If any provision of this Agreement shall be invalid or
unenforceable in any jurisdiction, such invalidity or unenforceability shall not
affect the validity or enforceability of the remainder of this Agreement or the
validity or enforceability of this Agreement in any other jurisdiction.

     (d) Notices. Any notices required or permitted to be given under the terms
of this Agreement shall be in writing and shall be sent by mail, personal
delivery, by telephone line facsimile transmission or courier and shall be
effective five days after being placed in the mail, if mailed, or upon receipt,
if delivered personally, by telephone line facsimile transmission or by courier,
in each case addressed to a party at such party's address (or telephone line
facsimile transmission number) shown in the introductory paragraph or on the
signature page of this Agreement or such other address (or telephone line
facsimile transmission number) as a party shall have

                                       31

<PAGE>

provided by notice to the other party in accordance with this provision. In the
case of any notice to the Company, such notice shall be addressed to the Company
at its address shown in the introductory paragraph of this Agreement, Attention:
Chief Financial Officer (telephone line facsimile number (650) 428- 3545), and a
copy shall also be given to: Latham & Watkins, 135 Commonwealth Drive, Menlo
Park, California 94025, Attn: Alan Mendelson (telephone line facsimile
transmission number (650) 463-2600), and in the case of any notice to the Buyer,
a copy shall be given to: Cooley Godward LLP, Five Palo Alto Square, 3000 El
Camino Real, Palo Alto, California 94306, Attn: Craig Dauchy (telephone line
facsimile transmission number (650) 849-7400). The Buyer hereby designates as
its address for any notice required or permitted to be given to the Buyer
pursuant to the Certificate of Designations the address shown on the signature
page of this Agreement, until the Buyer shall designate another address for such
purpose.

     (e) Counterparts. This Agreement may be executed in counterparts and by the
parties hereto on separate counterparts, each of which shall be deemed an
original but all of which together shall constitute one and the same instrument.
A telephone line facsimile transmission of this Agreement bearing a signature on
behalf of a party hereto shall be legal and binding on such party.

     (f) Entire Agreement; Benefit. This Agreement, including the Annexes and
Schedules hereto, constitutes the entire agreement between the parties hereto
with respect to the subject matter hereof. There are no restrictions, promises,
warranties, or undertakings, other than those set forth or referred to herein
and therein. This Agreement, including the Annexes and Schedules hereto,
supersedes all prior agreements and understandings, whether written or oral,
between the parties hereto with respect to the subject matter hereof. This
Agreement and the terms and provisions hereof are for the sole benefit of only
the Company, the Buyer and their respective successors and permitted assigns.

     (g) Waiver. Failure of any party to exercise any right or remedy under this
Agreement or otherwise, or delay by a party in exercising such right or remedy,
or course of dealing between the parties, shall not operate as a waiver thereof
or an amendment hereof, nor shall any single or partial exercise of any such
right or power, or any abandonment or discontinuance of steps to enforce such a
right or power, preclude any other or further exercise thereof or exercise of
any other right or power.

     (h) Amendment. No amendment, modification, waiver, discharge or termination
of any provision of this Agreement nor consent to any departure by the Buyer or
the Company therefrom shall in any event be effective unless the same shall be
in writing and signed by the party to be charged with enforcement, and then
shall be effective only in the specific instance and for the purpose for which
given. No course of dealing between the parties hereto shall operate as an
amendment of this Agreement.

     (i) Further Assurances. Each party to this Agreement will perform any and
all acts and execute any and all documents as may be necessary and proper under
the circumstances in order to accomplish the intents and purposes of this
Agreement and to carry out its provisions.

     (j) Assignment Of Certain Rights And Obligations. The rights of an Investor
under Sections 5, 8, 9, and 10 of this Agreement shall not be assigned by such
Investor to any transferee of all or any portion of such Investor's Registrable
Securities (or all or any portion of the Preferred Shares) without the prior
written consent of the Company. Upon any valid assignment, the Company shall be
obligated to such transferee to perform all of its covenants under Sections 5,
8, 9, and 10 of this Agreement as if such transferee were the Buyer. In
connection with any valid transfer the Company shall, at its sole cost and
expense, promptly after such assignment take such actions as shall be reasonably
acceptable to the transferring Investor and such transferee to assure that the
Registration Statement relating to the Registrable Securities involved in such
transfer and the Prospectus are available for use by such transferee for sales
of the Registrable Securities in respect of which such rights and obligations
have been so assigned.

     (k) Expenses. Each party shall pay all costs and expenses that it incurs
with respect to the negotiation, execution, delivery and performance of the
Agreement; provided, however, that the Company shall, at the

                                       32

<PAGE>

Closing, reimburse the reasonable fees of and expenses of Cooley Godward LLP,
counsel to the Buyer and the Other Buyers, for the Transaction Documents and the
due diligence relating to the transactions contemplated by the Transactions
Documents.

     (l) Termination.

          (i) The Buyer shall have the right to terminate this Agreement by
     giving notice to the Company at any time at or prior to the Closing Date
     if:

               (1) the Company shall have failed, refused, or been unable at or
          prior to the date of such termination of this Agreement to perform any
          of its obligations hereunder;

               (2) any other condition precedent set forth in Section 7 is not
          fulfilled; or

               (3) the Closing shall not have occurred on a Closing Date on or
          before November 30, 2001, other than solely by reason of a breach of
          this Agreement by the Buyer.

          (ii) The Company shall have the right to terminate this Agreement by
     giving notice to the Buyer at any time prior to the Closing Date if:

               (1) the Buyer shall have failed, refused, or been unable at or
          prior to the date of such termination of this Agreement to fulfill its
          payment obligations in accordance with Section 2; or

               (2) the Closing shall not have occurred on a Closing Date on or
          before November 30, 2001, other than solely by reason of a breach of
          this Agreement by the Company.

Any such termination shall be effective upon the giving of notice thereof by the
terminating party. Upon such termination, the terminating party shall have no
further obligation to the other party hereunder and the other party shall remain
liable for any breach of this Agreement or the other documents contemplated
hereby which occurred on or prior to the date of such termination.
Notwithstanding anything in the preceding sentence to the contrary, if this
Agreement is terminated for any reason other than pursuant to Section
10(l)(ii)(1), then the Company shall pay all reasonable costs and expenses, that
the Buyer and the Other Buyers incurred with respect to the negotiation,
execution, delivery and performance of the Transaction Documents.

     (m) Survival. The respective representations, warranties, covenants and
agreements of the Company and the Buyer contained in this Agreement and the
other Transaction Documents shall survive the execution and delivery of this
Agreement and the other Transaction Documents and the closing hereunder and the
delivery of and payment for the Preferred Shares and shall remain in full force
and effect regardless of any investigation made by or on behalf of the Buyer or
any Person controlling or acting on behalf of the Buyer or by the Company or any
Person controlling or acting on behalf of the Company.

     (n) Public Statements, Press Releases, Etc. The Company and the Buyer shall
have the right to approve before issuance any press releases or any other public
statements with respect to the transactions contemplated hereby; provided,
however, that the Company shall be entitled, without the prior approval of the
Buyer, to make any press release or other public disclosure with respect to such
transactions as is required by applicable law and regulations, including the
1933 Act and the rules and regulations promulgated thereunder (although the
Buyer shall be consulted by the Company in connection with any such press
release or other public disclosure prior to its release and shall be provided
with a copy thereof).

     (o) Construction. The language used in this Agreement will be deemed to be
the language chosen by the parties to express their mutual intent, and no rules
of strict construction will be applied against any party.

     (p) Notices. Attached hereto as ANNEX H are the notices required to be
delivered by the Company and/or the Buyer pursuant to the Certificate of
Designations.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

                                       33

<PAGE>

     In Witness Whereof, the parties have caused this Agreement to be duly
executed by their respective officers or other representatives thereunto duly
authorized as of the date first set forth above.

Number of Preferred Shares: ____________

Price Per Share: $1,000.00

Aggregate Purchase Price: ______________

Microcide Pharmaceuticals, Inc.

By: ____________________________________

Name: __________________________________

Title: _________________________________

[INVESTOR]

By: ____________________________________

Name: __________________________________

Title: _________________________________

Address: _______________________________

________________________________________

________________________________________

Facsimile No.: _________________________

                                       34

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