Document:

Executive Employment Agreement

 Exhibit 10.6.1 
  
 EXECUTIVE EMPLOYMENT AGREEMENT BETWEEN 
 JAMES D. SINEGAL AND COSTCO WHOLESALE CORPORATION 
  
 September 2, 2002 
  
 Jim Sinegal

 999 Lake Drive 
 Issaquah, WA 98027 
  
 Dear Jim: 
  
 This letter agreement confirms the terms of your
employment with Costco Wholesale Corporation (the “Company”): 
  

	1.
	 
	Employment.  The Company employs you as its President and Chief Executive Officer. 
 

  

	2.
	 
	Employment Term.  The terms of this letter agreement cover one year, beginning September 2, 2002, and coinciding with the Company’s fiscal
year 2003, unless otherwise terminated as provided below. The parties may renew this letter agreement from year-to-year upon agreement. 
 

  

	3.
	 
	Salary and Benefits. 
 

  

	 	(a)
	 
	You will receive a base salary of $350,000 for fiscal year 2003. The base salary will be paid to you in accordance with the Company’s standard payroll
practices. 
 

  

	 	(b)
	 
	You will be eligible for a bonus of up to $200,000. The amount of any bonus will be determined by the Board of Directors or the Compensation Committee, and will
be paid to you in accordance with the Company’s standard practices. 
 

  

	 	(c)
	 
	You will be eligible for a stock option grant under the Company’s stock option plan. The Board of Directors or the Compensation Committee will determine
the amount of any grant. 
 

  

	 	(d)
	 
	All payments to you will be subject to withholding for taxes and other applicable withholding requirements. 
 

  

	 	(e)
	 
	You will be eligible to participate in the Company’s employee benefit programs, in accordance with the terms and conditions of those programs.

 

  

	4.
	 
	Termination. The Company will have the right to terminate your employment at any time for “cause,” as determined under applicable law and
policies of the Company. You may terminate your employment at any time upon not less than sixty (60) days prior written notice. 
 

  

	5.
	 
	Miscellaneous. This letter agreement represents our complete agreement on these subjects. We can only amend this letter agreement by signing a written
amendment. This letter will be governed by Washington law in all respects. 
 

  
 If you agree with
the terms contained in this letter, please sign the enclosed copy of this letter and return it to me. 
  
 
	 Sincerely,
  
  
 Compensation Committee,
 Board of Directors,
 Costco Wholesale Corporation

	 
	 By:
 	 	 /s/    John Meisenbach        
 
	 	
	

	  	 	 John Meisenbach, Director
 

 
  
 
	 Acknowledged and agreed:
 
	 
	 /s/    Jim Sinegal
 
	

	 Jim Sinegal
 

 
  
 
	 Dated:
 	  	 October 5, 2002QuickLinks
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Exhibit 4.1    
  

 
 

SECOND AMENDMENT TO RIGHTS AGREEMENT    
  

        SECOND
AMENDMENT, dated as of November 21, 2002 (the "Amendment"), to the Rights Agreement, dated as of December 11, 1995
and amended on October 19, 2001 (as amended, the "Rights Agreement"), between Synaptic Pharmaceutical Corporation, a Delaware corporation (the
"Company"), and Mellon Investor Services LLC (formerly known as Chemical Mellon Shareholder Services), as rights agent (the
"Rights Agent"). 

W
I T N E S S E T H: 

        WHEREAS,
the Company is entering into an Agreement and Plan of Merger dated November 21, 2002 (as the same may be amended from time to time, the "Merger
Agreement") among the Company, Viking Sub Corporation, a Delaware corporation ("Sub"), and H. Lundbeck A/S, a Danish corporation
and the parent of the Sub (the "Parent"), pursuant to which, among other things, the Company will merge (the
"Merger") with the Sub and become a wholly-owned subsidiary of Parent, and the outstanding capital stock of the Company will be converted into the right
to receive cash; 

        WHEREAS,
the Company and the Rights Agent have heretofore executed and entered into the Rights Agreement; 

        WHEREAS,
pursuant to Section 27 of the Rights Agreement, prior to a Distribution Date (as defined therein), the Company and the Rights Agent may from time to time supplement or
amend the Rights Agreement in any respect without approval of any holders of certificates representing shares of Common
Stock, whether or not such supplement or amendment is adverse to any holders of rights under the Rights Agreement; and 

        WHEREAS,
the parties desire to amend the Rights Agreement in connection with the execution and delivery of the Merger Agreement and a Stockholder Agreement, dated as of
November 21, 2002, between the Parent and the stockholder listed therein (the "Stockholder Agreement") and the consummation of the transactions
contemplated thereby; and 

        WHEREAS,
the Board of Directors of the Company has determined that this Amendment is in the best interests of Rights holders; 

        NOW,
THEREFORE, in consideration of the foregoing and the mutual agreements set forth herein, the Company and the Rights Agent agree as follows: 

        1.    Notwithstanding
anything to the contrary contained in this Agreement, no Person shall be, deemed to be or become an Acquiring Person, and no Distribution Date, Stock
Acquisition Date or Triggering Event shall be deemed to have occurred by reason of (A) the execution and delivery of (i) the Merger Agreement, or (ii) the Stockholder Agreement,
or (B) the consummation of the transactions contemplated thereby. 

        2.    This
Amendment shall be deemed to be a contract made under the laws of the State of Delaware and for all purposes shall be governed by and construed in accordance with
the laws of such State applicable to contracts made and to be performed entirely within such State. This Amendment may be executed in any number of counterparts, each of such counterparts shall for
all purposes be deemed to be an original, and all such counterparts shall together constitute but one of the same instrument. If any term, provision, covenant or restriction of this Amendment is held
by a court of competent jurisdiction or other authority to be invalid, void or unenforceable, the remainder of the terms, provisions, covenants and restrictions of this Amendment shall remain in full
force and effect and shall in no way be affected, impaired or invalidated. The term "or" is not exclusive. 

        3.    The
term "Agreement" as used in the Rights Agreement shall be deemed to refer to the Rights Agreement as amended hereby. The foregoing amendments shall be effective as of
the date hereof and, except as set forth herein, the Rights Agreement shall remain in full force and effect and shall be otherwise unaffected hereby. 

 

        IN
WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed as of the day and year first above written. 

	 	 	SYNAPTIC PHARMACEUTICAL CORPORATION
	

 	
 	
By:	

/s/  ERROL B. DE SOUZA      
 Name: Errol B. De Souza

Title: President and CEO
	

 	
 	
MELLON INVESTOR SERVICES LLC, AS RIGHTS AGENT
	

 	
 	
By:	

/s/  JOHN W. COMER      
 Name: John W. Comer

Title: Vice President

2

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Exhibit 4.1

SECOND AMENDMENT TO RIGHTS AGREEMENT<Page>

                                                                     EXHIBIT 4.1

[GRAPHIC]

CUSIP 23342j206

SEE REVERSE FOR CERTAIN DEFINITIONS

COMMON STOCK

$.01 par value per share

This certificate is transferable in
New York, N.Y. and Ridgefield Park, N.J.

Incorporated under the laws of the State of Delaware

                           DADE BEHRING HOLDINGS, INC.

[GRAPHIC]

                              CERTIFICATE OF STOCK

             FULLY PAID AND NONASSESSABLE SHARES OF COMMON STOCK OF

   DADE BEHRING HOLDINGS, INC., TRANSFERABLE ON THE BOOKS OF THE CORPORATION
       BY THE HOLDER HEREOF IN PERSON OR BY DULY AUTHORIZED ATTORNEY UPON
      SURRENDER OF THIS CERTIFICATE PROPERLY ENDORSED OR ACCOMPANIED BY A
  PROPERLY SIGNED POWER OF ATTORNEY TO TRANSFER THE SAME. THIS CERTIFICATE IS
   NOT VALID UNTIL COUNTERSIGNED BY THE TRANSFER AGENT AND REGISTERED BY THE
                                   REGISTRAR.
  WITNESS THE FACSIMILE SEAL OF THE CORPORATION AND THE FACSIMILE SIGNATURES OF
                          ITS DULY AUTHORIZED OFFICERS.

Dated

  President &                 Secretary            CounterSigned and Registered:
  Chief Executive Officer                          MELLON INVESTOR SERVICES LLC
                                                   Transfer Agent and Registrar
                                                   By

  /s/ [ILLEGIBLE]             /s/ [ILLEGIBLE]      Authorized Officer

[GRAPHIC]

DADE BEHRING

<Page>

                           DADE BEHRING HOLDINGS, INC.

       The Corporation will furnish without charge to each stockholder who so
requests the powers, designations, preferences and relative, participating,
optional, or other special rights of each class of stock or series thereof and
the qualifications, limitations or restrictions of such preferences and/or
rights. Any such request should be addressed to the Secretary of Dade Behring
Holdings, Inc.

       This certificate also evidences and entitles the holder hereof to certain
rights as set forth in a Rights Agreement between Dade Behring Holdings, Inc.
and Mellon Investor Services LLC, dated as of October 3, 2002, as the same may
be amended, supplemented or otherwise modified from time to time (the "Rights
Agreement"), the terms of which are hereby incorporated herein by reference and
a copy of which is on file at the principal executive offices of Dade Behring
Holdings, Inc. Under certain circumstances, as set forth in the Rights
Agreement, such Rights will be evidenced by separate certificates and will no
longer be evidenced by this certificate. Dade Behring Holdings, Inc. will mail
to the holder of this certificate a copy of the Rights Agreement without charge
after receipt of a written request therefor. Under certain circumstances, as
set forth in the Rights Agreement, Rights owned by or transferred to any Person
who is or becomes an Acquiring Person (as defined in the Rights Agreement) and
certain transferees thereof will become null and void and will no longer be
transferable.

       The following abbreviations, when used in the Inscription on the face of
this certificate, shall be construed as though they were written out in full
according to applicable laws or regulations:

<Table>
          <S>                                           <C>
          TEN COM - as tenants in common                UNIF GIFT MIN ACT __________ As Custodian for ________
          TEN ENT - as tenants by the entireties                            (Cust)                     (Minor)
          JT TEN  - as joint tenants with right of                        Under Uniform Gifts to Minors
                    survivorship and not as tenants                       Act _______________
                    in common                                                     (State)
</Table>

     Additional abbreviations may also be used though not in the above list.

   For value received, _______________ hereby sell, assign and transfer unto

PLEASE INSERT SOCIAL SECURITY OR OTHER
   IDENTIFYING NUMBER OF ASSIGNEE

______________________________________

________________________________________________________________________________
  (PLEASE PRINT OR TYPEWRITE NAME AND ADDRESS, INCLUDING ZIP CODE, OF ASSIGNEE)

________________________________________________________________________________

________________________________________________________________________________

_________________________________________________________________________ Shares
of the common stock represented by the within Certificate, and do hereby
irrevocably constitute and appoint

_______________________________________________________________________ Attorney
to transfer the said stock on the books of the within named Corporation with
full power of substitution in the premises.

Dated ____________________________

                           ____________________________________________________
                           NOTICE: THE SIGNATURE(S) TO THIS ASSIGNMENT MUST
                                   CORRESPOND WITH THE NAME(S) AS WRITTEN UPON
                                   THE FACE OF THE CERTIFICATE IN EVERY
                                   PARTICULAR, WITHOUT ALTERATION OR ENLARGEMENT
                                   OR ANY CHANGE WHATEVER.

Signature(s) Guaranteed;

By _______________________________________________________________________
THE SIGNATURE(S) SHOULD BE GUARANTEED BY AN ELIGIBLE GUARANTOR INSTITUTION
(BANKS, STOCKBROKERS, SAVINGS AND LOAN ASSOCIATIONS AND CREDIT UNIONS WITH
MEMBERSHIP IN AN APPROVED SIGNATURE GUARANTEE MEDALLION PROGRAM), PURSUANT
TO S.E.C. RULE 17Ad-15.

KEEP THIS CERTIFICATE IN A SAFE PLACE, IF IT IS LOST, STOLEN, MUTILATED OR
DESTROYED, THE CORPORATION WILL REQUIRE A BOND OF INDEMNITY AS A CONDITION TO
THE ISSUANCE OF A REPLACEMENT CERTIFICATE.

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