Document:

EXHIBIT 10.2
                                                                    ------------

                             FIRST AMENDMENT TO THE

                           SECOND AMENDED AND RESTATED

                       MASTER TRADEMARK LICENSE AGREEMENT

                                     BETWEEN

                     SIGNAL INVESTMENT & MANAGEMENT COMPANY

                                       AND

                                  CHATTEM, INC.

                  This First Amendment to the Second Amended and Restated Master
Trademark License Agreement is made and entered into by and between Signal
Investment & Management Co., a Delaware corporation ("Signal"), having its
principal place of business at Suite 1300, 1105 Market Street, Wilmington,
Delaware 19890, and Chattem, Inc., a Tennessee corporation ("Chattem"), having
its principal place of business located at 1715 W. 38th Street, Chattanooga,
Tennessee 37409, effective as of ____________, 2003.

                  WHEREAS, Signal and Chattem entered into that certain Second
Amended and Restated Master Trademark License Agreement effective as of March
22, 2002 (the "Master Trademark License Agreement"), pursuant to which Signal
licenses to Chattem certain trademark rights; and

                  WHEREAS, Signal and Chattem desire to amend the Master
Trademark License Agreement as provided hereinafter.

                  NOW, THEREFORE, in consideration of the premises and of the
mutual covenants and agreements contained herein, the parties hereby agree as
follows:

                  1. Section 4.1 of the Master Trademark License Agreement shall
be deleted in its entirety and in lieu thereof shall be inserted the following:

                           4.1 Royalty. Licensee and its sublicensed
         Subsidiaries shall pay to Licensor a fifteen and two-tenths percent
         (15.2%) royalty on Net Sales of all Products sold under the Trademarks
         (the "Royalty"). The Royalty shall be payable quarterly within 45 days
         of the end of each of the Licensee's fiscal quarters.

                  2. Section 4.2 of the Master Trademark License Agreement shall
be deleted in its entirety and in lieu thereof shall be inserted the following:

<PAGE>

                           4.1 Sales by Subsidiaries. In the event that Licensee
         grants a sublicense to any Subsidiary, Licensee agrees to pay the
         fifteen and two-tenths percent (15.2%) Royalty due under Section 4.1 on
         all Net Sales of Products by such Subsidiary.

                  3. Except as expressly set forth herein, this First Amendment
shall not amend or otherwise modify the terms and conditions of the Master
Trademark License Agreement, which shall remain in full force and effect.

                  IN WITNESS WHEREOF, Licensor and Licensee have caused this
First Amendment to be signed in Wilmington, Delaware, effective as of the date
first above written.

                                  SIGNAL INVESTMENT & MANAGEMENT CO.

                                  By:_______________________________________
                                        A. Alexander Taylor II, President

                                  CHATTEM, INC.

                                  By:_______________________________________
                                        A. Alexander Taylor, II, President and
                                        Chief Operating OfficerEXHIBIT 10.3
                                                                    ------------

                               FIRST AMENDMENT TO

                       MASTER TRADEMARK LICENSE AGREEMENT

                                     BETWEEN

                     SIGNAL INVESTMENT & MANAGEMENT COMPANY

                                       AND

                                   SUNDEX, LLC

                  This First Amendment to Master Trademark License Agreement is
made and entered into by and between Signal Investment & Management Co., a
Delaware corporation ("Signal"), having its principal place of business at Suite
1300, 1105 Market Street, Wilmington, Delaware 19890, and SunDex, LLC, a
Tennessee limited liability company ("SunDex"), having its principal place of
business located at 1715 W. 38th Street, Chattanooga, Tennessee 37409, effective
as of ____________, 2003.

                  WHEREAS, Signal and SunDex entered into that certain Master
Trademark License Agreement effective as of March 22, 2002 (the "Master
Trademark License Agreement"), pursuant to which Signal licenses to SunDex
certain trademark rights; and

                  WHEREAS, Signal and SunDex desire to amend the Master
Trademark License Agreement as provided hereinafter.

                  NOW, THEREFORE, in consideration of the premises and of the
mutual covenants and agreements contained herein, the parties hereby agree as
follows:

                  1. Section 4.1 of the Master Trademark License Agreement shall
be deleted in its entirety and in lieu thereof shall be inserted the following:

                           4.1 Royalty. Licensee and its sublicensed
         Subsidiaries shall pay to Licensor a fifteen and two-tenths percent
         (15.2%) royalty on Net Sales of all Products sold under the Trademarks
         (the "Royalty"). The Royalty shall be payable quarterly within 45 days
         of the end of each of the Licensee's fiscal quarters.

                  2. Section 4.2 of the Master Trademark License Agreement shall
be deleted in its entirety and in lieu thereof shall be inserted the following:

                           4.1 Sales by Subsidiaries. In the event that Licensee
         grants a sublicense to any Subsidiary, Licensee agrees to pay the
         fifteen and two-tenths percent (15.2%) Royalty due under Section 4.1 on
         all Net Sales of Products by such Subsidiary.

<PAGE>

                  3. Except as expressly set forth herein, this First Amendment
shall not amend or otherwise modify the terms and conditions of the Master
Trademark License Agreement, which shall remain in full force and effect.

                  IN WITNESS WHEREOF, Licensor and Licensee have caused this
First Amendment to be signed in Wilmington, Delaware, effective as of the date
first above written.

                                     SIGNAL INVESTMENT & MANAGEMENT CO.

                                     By:_______________________________________
                                           A. Alexander Taylor II, President

                                     SUNDEX, LLC

                                     By:_______________________________________
                                           A. Alexander Taylor, II, PresidentExhibit 4.6

                         FORM OF SUBSCRIPTION AGREEMENT

                                HUMAN BIOSYSTEMS
                            A California corporation

        This Subscription Agreement is made by and between Human BioSystems, a
California corporation (the "Company") and ______________________, the
undersigned prospective purchaser who is subscribing hereby for the Securities.
In consideration of the Company's agreement to accept the undersigned as a
holder of Stock upon the terms and conditions set forth herein, the undersigned
agrees and represents as follows:

A.   SUBSCRIPTION

        1.   By executing this Subscription Agreement ("Agreement"), the
undersigned agrees to purchase an aggregate of ____________ shares of Common
Stock for an aggregate purchase price of $_____________, or $___________ per
share, upon acceptance of this offer by the Company, and tenders payment in full
herewith for such Securities (the "Payment").

        2.   The Payment will be returned promptly, without interest, in the
event that for any reason the purchase and sale of the Securities subscribed for
hereby is not consummated within 30 days following the date this Subscription
Agreement is duly executed and delivered by the undersigned (such date is
hereinafter referred to as the Closing Date) or in the event that the
undersigned's subscription is rejected.

B.  GENERAL REPRESENTATIONS AND WARRANTIES

        1.   The undersigned hereby represents and warrants to, and agrees with
the Company, as follows:

       (a)  The Securities are being purchased for his own account and not for
the account of any other person.

       (b)  The undersigned has carefully considered and has, to the extent he
or she believes such discussion necessary, discussed with his or her
professional legal, tax and financial advisers the suitability of an investment
in the Company for his or her particular tax and financial situation and the
undersigned has determined that the Securities are a suitable investment.

       (c)  The undersigned, or if the undersigned is an entity, the person
making the investment decision on behalf of the entity, has the capacity, by
reason of the undersigned's or such person's business or financial experience
(or that of the undersigned's purchaser representative) to evaluate the merits
and risks of an investment in the Securities and to protect the undersigned's
own interests in connection with such investment and the undersigned is able to
bear the economic risk of such investment.

2.   The foregoing representations and warranties are true and accurate as of
the date hereof, shall be true and accurate as of the date of the acceptance
hereof by the Company and shall survive thereafter.  If such representations and
warranties shall not be true and accurate in any respect, the undersigned will,
prior to such acceptance, give written notice of such fact to the Company
specifying which representations and warranties are not true and accurate and
the reasons therefor.

C.   UNDERSTANDINGS

        1.   The undersigned understands, acknowledges and agrees with the
Company as follows:

       (a)  This Subscription may be rejected, in whole or in part, by the
Company in its sole discretion, at any time prior to the execution and delivery
hereof by the Company, notwithstanding prior receipt by the undersigned of
notice of acceptance of the undersigned's subscription.

       (b)  This Subscription is and shall be irrevocable, except that the
undersigned shall have no obligations hereunder in the event that: (i) this
subscription is rejected for any reason or (ii) the purchase and sale of the
Securities subscribed for hereby are not consummated.

      (c)  No federal or state agency has made any finding or determination as
to the fairness of this offering for investment, nor any recommendation or
endorsement of the Securities.

      2. The representations, warranties, understandings, acknowledgments and
agreements in this Agreement are true and accurate as of the date hereof, shall
be true and accurate as of the date of the acceptance hereof by the Company and
shall survive thereafter.

E.   MISCELLANEOUS

     1.  All pronouns and any variations thereof used herein shall be deemed to
refer to the masculine, feminine, neuter, singular or plural as the identity of
the person or persons may require.

     2.  Neither this Subscription Agreement nor any provisions hereof shall be
waived, modified, changed, discharged, terminated, revoked or canceled except by
an instrument in writing signed by the party against whom any such waiver,
modification, change, discharge, termination, revocation or cancellation is
sought.

    3.  Notices required or permitted to be given hereunder shall be in writing
and shall be deemed to be sufficiently given when personally delivered or sent
by registered mail, return receipt requested, addressed to the other party at
the address of such party set forth herein, or to such other address furnished
by notice given in accordance with this Article E.

    4.  Failure of the Company to exercise any right or remedy under this
Subscription Agreement or any other agreement between the Company and the
undersigned, or otherwise, or delay by the Company in exercising such right or
remedy, shall not operate as a waiver thereof.  No waiver by the Company shall
be effective unless and until it is in writing and signed by the Company.

    5.  This Subscription Agreement shall be enforced, governed and construed in
all respects in accordance with the laws of the State of California, as such
laws are applied by California courts to agreements entered into and to be
performed in California by and between residents of California, and shall be
binding upon the undersigned, his heirs, estate, legal representatives,
successors and assigns and shall inure to the benefit of the Company and its
successors and assigns.

   6.  In the event that any provision of this Subscription Agreement is
declared invalid or unenforceable by a court of competent jurisdiction under any
applicable statute or rule of law, then such provision shall be deemed
inoperative to the extent that it may conflict therewith and shall be deemed
modified to conform with such statute or rule of law.  Any provision hereof
which may prove invalid or unenforceable under any law shall not affect the
validity or enforceability of any other provision hereof.

   7.  This Subscription Agreement constitutes the entire agreement among the
parties hereto with respect to the subject matter hereof and supersedes any and
all prior or contemporaneous representations, warranties, agreements and
understandings in connection therewith.  This Subscription Agreement may be
amended only by a writing executed by all parties hereto.

  8.  Title to the Securities shall be taken as follows: (check one):

      (  ) Husband and wife, as community property;
      (  ) Joint Tenants;
      (  ) Tenants in common;
      (  ) Separate property;
      (  ) Living Trust;
      (  ) Corporation (Attach copy of resolution authorizing this investment);
      (  ) Partnership (Attach copy of partnership agreement);
      (  ) Custodian, Trustee (Attach copy of agreement);
      (  ) Other:

                                HUMAN BIOSYSTEMS
                             SUBSCRIPTION AGREEMENT
                                 SIGNATURE PAGE

        This page constitutes the signature Page for the Subscription Agreement.
The undersigned represents to you that (a) the information contained herein is
complete and accurate on the date hereof and may be relied upon by you and (b)
the undersigned will notify you immediately of any change in any of such
information occurring prior to the acceptance of the subscription and will
promptly send you written confirmation of such change. The undersigned hereby
certifies that he has read and understands the Plan and this Subscription
Agreement.

        IN WITNESS WHEREOF, the undersigned has executed this Subscription
Agreement this ___ day of ____________, 200__.

_____________________                   $ _____________________
Number of Shares of                       Total Purchase Price
Common Stock

                                   _______________________________
                                   NAME OF PURCHASER, Print or Type
                                  (as it is to appear on the stock certificate)

                                  _______________________________
                                  Signature

                                  _______________________________

                                  _______________________________
                                  Address

                                  ______________  __________________
                                  Phone Number    Social Security # or
                                                  Federal ID #

                                  ______________  __________________
                                  Fax Number      Email Address

                                  _________________________________
                                  Title of Authorized Signature if Purchaser
                                  is a corporation, partnership or other entity

                                  _________________________________
                                  Signature of Spouse or Co-Owner

                                  __________________________________
                                  Social Security # of Spouse or Co-Owner

Accepted on __________, 200__
For Human BioSystems:

_______________________________
Harry Masuda, President and
Chief Executive Officer

IF PURCHASER IS A CORPORATION, PARTNERSHIP OR OTHER ENTITY; A COPY OF THE BOARD
OF DIRECTOR'S RESOLUTION AUTHORIZING THIS INVESTMENT; A COPY OF THE PARTNERSHIP
AGREEMENT; OR IN THE CASE OF ANY OTHER ENTITY A COPY OF SUCH AGREEMENT AUTHORING
THIS INVESTMENT MUST BE ATTACHED.

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