Document:

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                       TWIN LABORATORIES INC., as Issuer,

                                       and

                           THE GUARANTORS NAMED HEREIN

                                       and

                 STATE STREET BANK AND TRUST COMPANY, as Trustee

                          FIFTH SUPPLEMENTAL INDENTURE

                           Dated as of March 30, 2001

                                       to

                                    INDENTURE

                             Dated As of May 7, 1996
           as supplemented as of December 1,1997 ,as of May 14, 1998,
               as of September 15, 1998 and as of January 25, 2000

                   10-1/4% Senior Subordinated Notes due 2006
<PAGE>   2
            FIFTH SUPPLEMENTAL INDENTURE, dated as of March 30, 2001, by and
among TWIN LABORATORIES INC., a Utah corporation (the "Company"), ADVANCED
RESEARCH PRESS, INC., a New York corporation ("Advanced"), TWINLAB CORPORATION,
a Delaware corporation formerly named TLG Laboratories Holding Corp. ("Holding
Company"), CHANGES INTERNATIONAL, INC., a Florida corporation ("Changes"),
BRONSON LABORATORIES INC., a Delaware Corporation ("Bronson"), HEALTH FACTORS
INTERNATIONAL, INC., a Delaware corporation ("Health Factors"), PR NUTRITION,
INC., a California corporation ("PR Nutrition"), Twinlab FSC Inc., a Barbados
corporation ("FSC"), CHANGES INTERNATIONAL (UK) LTD., a United Kingdom
corporation ("Changes UK") and TWIN LABORATORIES (UK) LTD, a United Kingdom
corporation ("Twin UK") and TWINLAB PASSION, LIMITED, a United Kingdom limited
liability company ("Passion"), as Guarantors, and State Street Bank and Trust
Company, a Massachusetts bank and trust company (successor to Fleet National
Bank), as Trustee (the "Trustee").

            WHEREAS, the Company, Advanced, Holding Company and Fleet National
Bank, as Trustee, executed an Indenture, dated as of May 7, 1996 (the
"Indenture"), in respect of $100,000,000 aggregate principal amount of the
Company's 10-1/4% Senior Subordinated Notes due 2006 (the "Securities");

            WHEREAS, State Street Bank and Trust Company is the successor to
Fleet National Bank, as Trustee under the Indenture;

            WHEREAS, the Company, Advanced, Holding Company, Changes and the
Trustee executed the First Supplemental Indenture dated as of December 1, 1997
(the "First Supplemental Indenture");

            WHEREAS, the Company, Advanced, Holding Company, Changes, Bronson,
Health Factors and the Trustee executed the Second Supplemental Indenture dated
as of May 14, 1998 (the "Second Supplemental Indenture");

            WHEREAS, the Company, Advanced, Holding Company, Changes, Bronson,
Health Factors, PR Nutrition and the Trustee executed the Third Supplemental
Indenture dated as of September 15, 1998 (the "Third Supplemental Indenture");

            WHEREAS, the Company, Advanced, Holding Company, Changes, Bronson,
Health Factors, PR Nutrition, FSC and the Trustee executed the Fourth
Supplemental Indenture dated as of June 25, 2000 (the "Fourth Supplemental
Indenture");

            WHEREAS, the term Indenture as hereinafter used in this Fifth
Supplemental Indenture shall mean the Indenture as amended by the First
Supplemental Indenture, the Second Supplemental Indenture, the Third
Supplemental Indenture and the Fourth Supplemental Indenture;
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            WHEREAS, Section 11.3 of the Indenture requires, under circumstances
specified in Section 11.3, that certain Subsidiaries of the Company execute and
deliver to the Trustee a supplemental indenture pursuant to which such
Subsidiaries of the Company shall be named as additional Subsidiary Guarantors;
and

            WHEREAS, all conditions and requirements necessary to make this
Fifth Supplemental Indenture a valid, binding and legal instrument in accordance
with its terms have been performed and fulfilled and the execution and delivery
hereof have been in all respects duly authorized.

            NOW, THEREFORE, in consideration of the above premises, each party
agrees, for the benefit of each other party and for the equal and ratable
benefit of the Holders of the Securities, as follows:

                                    ARTICLE I

                                   AMENDMENTS

            Section 1. The Company, Advanced, Holding Company, Changes, Bronson,
Health Factors, PR Nutrition, FSC and the Trustee hereby amend the Indenture and
agree that Changes UK, Twin UK and Passion shall each be a Subsidiary Guarantor,
a Guarantor and a Future Subsidiary Guarantor for all purposes under the
Indenture and each of the terms "Subsidiary Guarantor", "Guarantor" and "Future
Subsidiary Guarantor" shall for all purposes under the Indenture specifically
include Changes UK, Twin UK and Passion.

                                   ARTICLE II

                            MISCELLANEOUS PROVISIONS

            Section 2.1. Terms Defined. For all purposes of this Fifth
Supplemental Indenture, except as otherwise defined or unless the context
otherwise requires, terms used in capitalized form in this Fifth Supplemental
Indenture and defined in the Indenture have the meanings specified in the
Indenture.

            Section 2.2. Indenture. Except as amended hereby, the Indenture and
the Securities are in all respects ratified and confirmed and all their terms
shall remain in full force and effect.

            Section 2.3. Governing Law. THIS FIFTH SUPPLEMENTAL INDENTURE SHALL
BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW
YORK, AS APPLIED TO CONTRACTS MADE AND PERFORMED WITHIN THE STATE OF NEW YORK,
WITHOUT REGARD TO PRINCIPLES OF CONFLICT OF LAWS.

                                       3
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            Section 2.4. Successors and Assigns. All agreements of the Company,
Advanced, Holding Company, Changes, Bronson, Health Factors, PR Nutrition, FSC,
Changes UK, Twin UK and Passion in this Fifth Supplemental Indenture and the
Securities shall bind their respective successors and assigns.

            Section 2.5. Multiple Counterparts. This Fifth Supplemental
Indenture may be executed in any number of counterparts, each of which shall be
an original; but such counterparts shall together constitute but one and the
same instrument.

            Section 2.6. Effectiveness. The provisions of this Fifth
Supplemental Indenture shall become effective immediately upon its execution and
delivery by the Trustee in accordance with the provisions of Article IX of the
Indenture.

            Section 2.7. Trustee Disclaimer. The Trustee accepts the amendment
of the Indenture effected by this Fifth Supplemental Indenture and agrees to
execute the trust created by the Indenture as hereby amended, but only upon the
terms and conditions set forth in the Indenture, including the terms and
provisions defining and limiting the liabilities and responsibilities of the
Trustee, which terms and provisions shall in like manner define and limit its
liabilities and responsibilities in the performance of the trust created by the
Indenture as hereby amended, and, without limiting the generality of the
foregoing, the Trustee shall not be responsible in any manner whatsoever for or
with respect to any of the recitals (other than the second recital) or
statements contained herein, all of which recitals or statements are made solely
by the Company, Advanced, Holding Company, Changes, Bronson, Health Factors, PR
Nutrition, FSC, Changes UK, Twin UK and Passion or for or with respect to (i)
the validity, efficacy or sufficiency of this Fifth Supplemental Indenture or
any of the terms or provisions hereof, (ii) the proper authorization hereof by
the Company, Advanced, Holding Company, Changes, Bronson, Health Factors, PR
Nutrition, FSC, Changes UK, Twin UK and Passion by corporate action or
otherwise, (iii) the due execution hereof by the Company, Advanced, Holding
Company, Changes, Bronson, Health Factors, PR Nutrition, FSC, Changes UK, Twin
UK and Passion, or (iv) the consequences (direct or indirect and whether
deliberate or inadvertent) of any amendment herein provided for, and the Trustee
makes no representation with respect to any such matters.

            Section 2.8 Headings. The headings of the Articles and Sections of
this Fifth Supplemental Indenture have been inserted for convenience of
reference only, are not to be considered a part hereof and shall in no way
modify or restrict any of the terms or provisions hereof.

                     [Remainder of Page Intentionally Blank]

                                       4
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                                   SIGNATURES

            IN WITNESS WHEREOF, the parties hereto have caused this Fifth
Supplemental Indenture to be duly executed, all as of the date first written
above.

TWIN LABORATORIES INC., as Issuer           TWINLAB CORPORATION

By: _________________________               By: ___________________________
      Name: Ross Blechman                   Name: Ross Blechman
      Title: CEO & President                     Title: CEO & President

ADVANCED RESEARCH PRESS, INC.               CHANGES INTERNATIONAL, INC.

By: _________________________               By: ___________________________
      Name: Ross Blechman                   Name: Ross Blechman
      Title: Chairman & Director                 Title: President

BRONSON LABORATORIES, INC.                  HEALTH FACTORS INTERNATIONAL, INC.

By: _________________________                By: ___________________________
      Name: Ross Blechman                    Name: Ross Blechman
      Title: CEO & President                      Title: CEO & President

TWINLAB FSC INC.                             PR NUTRITION, INC.

By: _________________________                By: ___________________________
      Name: Ross Blechman                    Name: Ross Blechman
      Title: President & Director                 Title: CEO & President

EXECUTED AS A DEED BY                        EXECUTED AS A DEED BY
TWIN LABORATORIES (UK) LTD.                  CHANGES INTERNATIONAL (UK)  LTD.
ACTING BY ONE DIRECTOR AND THE COMPANY       ACTING BY ONE DIRECTOR AND THE
SECRETARY                                    COMPANY SECRETARY

By:___________________________               By:___________________________
      Name: Ross Blechman                         Name: Ross Blechman
      Title: Director                             Title: Director

By:___________________________               By:___________________________
      Name: Neil Blechman                         Name: Neil Blechman
      Title: Secretary                            Title: Secretary

STATE STREET BANK AND
TRUST COMPANY, AS TRUSTEE

By:___________________________
      Name: Elizabeth C. Hammer
      Title: Vice President

                                       5
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EXECUTED AS A DEED BY
TWINLAB PASSION, LIMITED
ACTING BY ONE DIRECTOR AND THE COMPANY
SECRETARY

By:___________________________
      Name: Emma Martin
      Title: Secretary

By:___________________________
      Name: Dr. N. Dean Pasha
      Title: Director

                                       6<PAGE>   1
                                                                  EXECUTION COPY

                           FOURTH AMENDMENT AND WAIVER

                  FOURTH AMENDMENT AND WAIVER, dated as of December 15, 2000
(this "Amendment"), to the Amended and Restated Credit and Guarantee Agreement,
dated as of November 15, 1996 (as amended, supplemented or otherwise modified
from time to time, the "Credit Agreement"), among Twinlab Corporation, a
Delaware corporation ("Holdings"), Twin Laboratories Inc., a Utah corporation
(the "Borrower"), the several banks and other financial institutions parties to
the Credit Agreement (the "Lenders"), The Bank of New York, as co-agent for the
Lenders thereunder (in such capacity, the "Co-Agent"), and The Chase Manhattan
Bank, as administrative agent for the Lenders thereunder (in such capacity, the
"Administrative Agent").

                              W I T N E S S E T H:

                  WHEREAS, the Borrower has requested that the Administrative
Agent and the Lenders amend the Credit Agreement and waive certain covenants and
defaults arising from the Borrower's failure to comply with certain covenants;

                  WHEREAS, the Administrative Agent and the Lenders are willing
to agree to the requested amendments and waivers on the terms and conditions
contained herein;

                  NOW, THEREFORE, in consideration of the premises and the
mutual covenants contained herein, the parties agree as follows:

                  1. Definitions. Unless otherwise defined herein, terms defined
in the Credit Agreement shall have their defined meanings when used herein.

                  2. Amendment to Subsection 1.1 (Definitions). Subsection 1.1
of the Credit Agreement is hereby amended as follows:

                  (a) by adding the following definitions in their proper
         alphabetical order:

                  "Accounts": all of the accounts, instruments, documents,
         chattel paper and general intangibles of the Borrower or any of its
         Domestic Subsidiaries, whether secured or unsecured, whether now
         existing or hereafter created or arising, and whether or not
         specifically assigned to the Administrative Agent for the ratable
         benefit of the Lenders.

                  "Account Debtor": the Person obligated on an Account.

                  "Amendment Period": the period from and including the Fourth
         Amendment Effective Date to and including February 15, 2001.

                  "Bad Debt Reserve": a reserve for bad debt calculated in
         accordance with GAAP on the Borrower's financial statements.
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                  "Borrowing Base": on any date, the amount (calculated based on
         the most recent Borrowing Base Certificate delivered pursuant to this
         Agreement) that is equal to the sum of (a) 80% of the Eligible Accounts
         Receivable plus (b) 40% of the Eligible Inventory. Borrowing Base
         component definitions and reserves may be fixed and revised from time
         to time by the Administrative Agent in its Permitted Discretion.

                  "Borrowing Base Certificate": a certificate substantially in
         the form of Exhibit J hereto (with such changes therein as may be
         required by the Administrative Agent to reflect the components of and
         reserves against the Borrowing Base as provided for hereunder from time
         to time), executed and certified by a Responsible Officer, which shall
         include appropriate exhibits and schedules as referred to therein and
         as provided for in subsection 6.2.

                  "Borrowing Base Effective Date": the date upon which a
         Borrowing Base shall have been determined.

                  "Eligible Accounts Receivable": at the time of any
         determination thereof, all Accounts that satisfy the following criteria
         at the time of creation and continue to meet the same at the time of
         such determination: (i) have been invoiced and represent the bona fide
         sale and delivery from the Borrower or the Domestic Subsidiaries to the
         purchaser of merchandise or services, in each case in the ordinary
         course of business of the Borrower or the Domestic Subsidiaries in
         connection with its trade operations and (ii) are not ineligible for
         inclusion in the calculation of the Borrowing Base pursuant to any of
         clauses (a) through (h) below or otherwise deemed by the Administrative
         Agent in good faith to be ineligible for inclusion in the calculation
         of the Borrowing Base as described below. Without limiting the
         foregoing, to qualify as an Eligible Account Receivable, an Account
         shall indicate as sole payee and as sole remittance party the Borrower
         or any of the Domestic Subsidiaries. In determining the amount to be so
         included, the face amount of Accounts shall be reduced by, without
         duplication, to the extent not reflected in such face amount, (i) the
         amount of all accrued and actual returns, discounts, claims, credits or
         credits pending, charges, price adjustments, freight or finance charges
         or other allowances (including any amount that the Borrower or the
         Domestic Subsidiaries, as applicable, may be obligated to rebate to a
         customer pursuant to the terms of any agreement or understanding
         (written or oral)), (ii) the aggregate amount of all reserves, limits
         and deductions provided for in this definition and elsewhere in this
         Agreement, and (iii) the aggregate amount of all credits not yet
         processed or applied by the Borrower or the applicable Domestic
         Subsidiary to reduce the amount of the Accounts. Standards of
         eligibility may be fixed from time to time by the Administrative Agent
         in its Permitted Discretion, with any changes in such standards to be
         effective 10 days after delivery of notice thereof to the Borrower.
         Unless otherwise approved from time to time in writing by the
         Administrative Agent, no Account shall be an Eligible Accounts
         Receivable if, without duplication:

                           (a) the Borrower or the Domestic Subsidiaries do not
                  have sole lawful and absolute title to such Account; or
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                           (b) it arises out of a sale made by the Borrower or
                  any Domestic Subsidiary to an employee, officer, agent,
                  director, or Affiliate of the Borrower or any Subsidiary; or

                           (c) it is unpaid more than 90 days from the date of
                  invoice or, in the case of General Nutrition Centers, 120 days
                  from the date of invoice or 60 days from the due date; or

                           (d) it has been written off the books of the Borrower
                  or the Domestic Subsidiaries or has been otherwise designated
                  on such books as uncollectible as part of the Borrower's Bad
                  Debt Reserve; or

                           (e) the Account is not payable in Dollars or the
                  Account Debtor is either not incorporated or organized under
                  the laws of the United States of America, any state thereof or
                  the District of Columbia or is located outside or has its
                  principal place of business or substantially all of its assets
                  outside the United States of America, except to the extent the
                  Account is supported by an irrevocable letter of credit
                  reasonably satisfactory to the Administrative Agent (as to
                  form, substance and issuer) and assigned to and directly
                  drawable by the Administrative Agent; or

                           (f) the Account Debtor is the United States of
                  America or any department, agency or instrumentality thereof,
                  unless the Borrower or the relevant Domestic Subsidiary, duly
                  assigns its rights to payment of such Account to the
                  Administrative Agent pursuant to the Assignment of Claims Act
                  of 1940, as amended, which assignment and related documents
                  and filings shall be in form and substance reasonably
                  satisfactory to the Administrative Agent; or

                           (g) the Account does not comply in all material
                  respects with all applicable Requirements of Law, whether
                  Federal, state or local, including without limitation, all
                  usury laws, fair credit reporting and billing laws, fair debt
                  collection practices and rules, and regulations relating to
                  truth in lending and other similar matters; or

                           (h) (i) it is not subject to a valid and perfected
                  first priority Lien in favor of the Administrative Agent for
                  the benefit of the Lenders, subject to no other Liens other
                  than the Liens (if any) permitted by the Loan Documents or
                  (ii) it does not otherwise conform in all material respects to
                  the representations and warranties contained in the Loan
                  Documents relating to Accounts.

                  "Eligible Inventory": at the time of any determination
         thereof, without duplication, all Inventory at the time of such
         determination that is not ineligible for inclusion in the calculation
         of the Borrowing Base pursuant to any of clauses (a) through (j) below
         or otherwise deemed by the Administrative Agent in good faith to be
         ineligible for inclusion in the calculation of the Borrowing Base as
         described below. Without limiting the foregoing, to qualify as
         "Eligible Inventory" no person other than the Borrower or the Domestic
         Subsidiaries shall have any direct or indirect ownership
<PAGE>   4
                                                                               4

         interest or title to such Inventory and no person other than the
         Borrower or the Domestic Subsidiaries shall be indicated on any
         purchase order or invoice with respect to such Inventory as having or
         purporting to have an interest therein. Standards of eligibility may be
         fixed from time to time by the Administrative Agent in its Permitted
         Discretion, with any changes in such standards to be effective 10 days
         after delivery of notice thereof to the Borrower. Unless otherwise from
         time to time approved in writing by the Administrative Agent, no
         Inventory shall be deemed Eligible Inventory if, without duplication:

                           (a) the Borrower or the Domestic Subsidiaries do not
                  have sole and good, valid and unencumbered title thereto; or

                           (b) it is not located in the United States of
                  America; or

                           (c) it is not located on property owned or leased by
                  the Borrower or the Domestic Subsidiaries or in a contract
                  warehouse, and, except as otherwise approved by the
                  Administrative Agent, covered by an agreement reasonably
                  satisfactory in form and substance to the Administrative Agent
                  covering the Administrative Agent's access to such Inventory
                  and waiving the lessor's or contract warehouseman's Liens
                  therein and segregated or otherwise separately identifiable
                  from goods of all others, if any, stored on the premises; or

                           (d) in the case of Raw Materials, it is components
                  including all packaging materials such as bottles, labels,
                  caps, capsules, containers, dividers, cartons and display
                  items; or

                           (e) in the case of Work-in-Process, it is any item
                  other than Inventory stored in bulk awaiting packaging; or

                           (f) in the case of Finished Goods Inventory, those
                  items that are accrued returns which are not in the possession
                  of the Borrower or the Domestic Subsidiaries or those items
                  that are not in a readily saleable form; or

                           (g) it is packing or shipping materials or supplies;
                  or

                           (h) it is not subject to a valid and perfected first
                  priority Lien in favor of the Administrative Agent for the
                  benefit of the Lenders; or

                           (i) it is accounted for in the Borrower's or the
                  Domestic Subsidiaries' Inventory Reserves; or

                           (j) it is in transit from anywhere outside the United
                  States of America.

                  Without limiting the foregoing, Inventory shall not be
         Eligible Inventory if the purchase order, invoice or any other document
         in connection therewith indicates that any Person other than the
         Borrower or the Domestic Subsidiaries has any ownership interest
         therein.
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                                                                               5

                  "Finished Goods": goods to be sold by the Borrower or the
         Domestic Subsidiaries in the ordinary course of business.

                  "Fourth Amendment Effective Date": as defined in the Fourth
         Amendment and Waiver to this Agreement, dated as of December 15, 2000.

                  "Inventory": all Raw Materials, Work-in-Process, and Finished
         Goods held by the Borrower or the Domestic Subsidiaries in the normal
         course of business.

                  "Inventory Reserves": the Inventory Value of all Inventory
         that (i) is inactive, experimental, seconds or thirds or stale (past
         best-used date), obsolete, excess, slow-moving, discontinued, or
         unmerchantable, (ii) is damaged or not in good condition or designated
         as close-out Inventory; (iii) is a sample; (iv) is not readily usable
         or salable under the customary terms upon which it usually is sold or
         at prices approximating at least the cost thereof (after giving effect
         to any write downs applicable thereto); or (v) does not otherwise
         conform to the representations and warranties contained in the Loan
         Documents.

                  "Inventory Value": a dollar amount equal to the lesser of (i)
         the standard cost of Inventory determined on a basis consistent with
         GAAP and with the Borrower's current and historical accounting practice
         or (ii) the market value of such Inventory.

                  "Permitted Discretion": the Administrative Agent's reasonable
         judgment exercised in good faith and based upon its standard practice.

                  "Raw Materials": materials used or consumed in the
         manufacture, packing or shipping of goods to be sold by the Borrower or
         the Domestic Subsidiaries in the normal course of business.

                  "Work-in-Process": goods which are currently in the process of
         being manufactured to be sold as Finished Goods.

                  (b) by amending the definition of "Applicable Margin" by
inserting at the end thereof the following:

                  Notwithstanding the foregoing, during the Amendment Period,
                  the Applicable Margin shall be 2.50%, if such Loans are ABR
                  Loans, and 3.50%, if such Loans are Eurodollar Loans.

                  (c) by amending the definition of "Interest Payment Date" by
(i) deleting the words "the last day of each April, July, October and January"
appearing in clause (a) therein and (ii) inserting, in lieu thereof, "the last
day of each calendar month".

                  (d) by amending the definition of "Interest Period" by
inserting at the end thereof the following:
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                                                                               6

                  Notwithstanding the foregoing, the Borrower hereby
                  acknowledges and agrees that, during the Amendment Period, it
                  shall not request a Eurodollar Loan with an Interest Period in
                  excess of one month.

                  (e) by amending the definition of "Swing Line Commitment" by
inserting at the end thereof before the period mark the following:

                  ; provided that during the Amendment Period, such Swing Line
                  Commitment shall be equal to $0

                  3. Amendment to Subsection 2.1 (Revolving Credit Commitments).
Subsection 2.1 of the Credit Agreement is hereby amended by adding immediately
prior to the period mark at the end of the first sentence of paragraph (a) the
following:

                  ; provided that no Lender shall be required to make any
                  Revolving Credit Loan if, after giving effect to the making of
                  such Revolving Credit Loan, the Extensions of Credit at such
                  time would exceed the Borrowing Base at such time.

                  4. Amendments to Subsection 2.3 (Commitment and Other Fees).
Subsection 2.3 of the Credit Agreement is hereby amended as follows:

                  (a) by (i) deleting "quarterly in arrears on the last day of
each April, July, October and January" where such words appear in paragraph (a)
and (ii) inserting, in lieu thereof, "on the last day of each calendar month";
and

                  (b) by inserting at the end of paragraph (a) thereof the
following:

                  Notwithstanding the foregoing, during the Amendment Period,
                  the commitment fee shall be computed at a rate of .50% per
                  annum.

                  5. Amendment to Subsection 2.6 (Swing Line Commitment).
Subsection 2.6 of the Credit Agreement is hereby amended by adding immediately
prior to the period mark at the end of the first sentence the following:

                  ; provided, further, that the Borrower shall not request, and
                  the Swing Line Lender shall not make, any Swing Line Loan if,
                  after giving effect to the making of such Swing Line Loan, the
                  Extensions of Credit at such time would exceed the Borrowing
                  Base at such time

                  6. Amendment to Subsection 2.10(a) (L/C Commitment).
Subsection 2.10(a) of the Credit Agreement is hereby amended by adding
immediately prior to the period mark at the end thereof the following:

                  or (iii) the Extensions of Credit at such time would exceed
                  the Borrowing Base at such time; provided, further, that the
                  Issuing Bank shall have no obligation to issue any Letter of
                  Credit during the Amendment Period
<PAGE>   7
                                                                               7

                  7. Amendment to Subsection 2.12(a) (Fees, Commissions and
Other Charges). Subsection 2.12(a) of the Credit Agreement is hereby amended by
(i) deleting "1/5" where it appears therein and (ii) inserting, in lieu thereof,
"1/4".

                  8. Amendment to Subsection 3.1 (Optional and Mandatory
Prepayments). Subsection 3.1 of the Credit Agreement is hereby amended as
follows:

                  (a) by (i) deleting paragraph (b) thereof in its entirety and
(ii) inserting, in lieu thereof, the following new paragraph (b):

                  (b) Unless the Required Lenders otherwise agree, the Revolving
                  Credit Commitments shall be permanently reduced with (i) 100%
                  of the Net Proceeds of any Equity Offering by Holdings or any
                  incurrence of Indebtedness by any Loan Party on or after the
                  Fourth Amendment Effective Date (other than any Indebtedness
                  permitted pursuant to subsection 7.2); (ii) 100% of the Net
                  Proceeds of any Asset Sale by the Borrower or any of its
                  Subsidiaries pursuant to subsection 7.6 and (iii) 100% of
                  federal and state tax refunds received. Each such reduction
                  shall be made on or before the date that is three Business
                  Days after the date any Loan Party receives such Net Proceeds
                  or such tax refunds.

                  (b) by adding the following new paragraph (d):

                  (d) If, at any time, the Extensions of Credit at such time
                  exceed the Borrowing Base at such time, the Borrower shall,
                  without notice or demand, immediately repay Swing Line Loans
                  then outstanding and/or, after the Swing Line Loans have been
                  paid in full, Revolving Loans in an aggregate principal amount
                  equal to the lesser of (i) the amount of such excess and (ii)
                  the aggregate principal amount of Swing Line Loans and
                  Revolving Loans then outstanding, together with interest
                  accrued to the date of such payment or prepayment on the
                  principal so prepaid and any amounts payable under subsection
                  3.11 in connection therewith.

                  (c) by adding the following new paragraph (e):

                  (e) If, on any Friday, the aggregate amount of cash and Cash
                  Equivalents held and available for use by the Borrower and its
                  Subsidiaries exceeds $5,000,000, the Borrower shall without
                  notice or demand, immediately repay Swing Line Loans then
                  outstanding and/or after Swing Line Loans have been paid in
                  full, Revolving Loans in an aggregate principal amount equal
                  to such excess.

                  9. Amendment to Subsection 5.2 (Conditions to Each Extension
of Credit). Subsection 5.2 of the Credit Agreement is hereby amended as follows:

                  (a) by adding the following new subsection (e):

                  (e) Borrowing Base Compliance. After giving effect to the
                  Extension of Credit requested to be made on any such date and
                  the use of the proceeds thereof,
<PAGE>   8
                                                                               8

                  the Extensions of Credit of all Lenders at such time shall not
                  exceed the Borrowing Base on such date.

                  (b) by inserting "and (e)" after the words "clauses (a) and
(b)" where such words appear in the last sentence of such subsection.

                  10. Amendment to Subsection 6.2 (Certificates; Other
Information). Subsection 6.2 of the Credit Agreement is hereby amended by (i)
deleting "and" where it appears after the semi-colon at the end of paragraph
(e); (ii) deleting the period mark where it appears at the end of paragraph (f)
and inserting, in lieu thereof, a semi-colon; and (iii) adding the following new
paragraph (g) and paragraph (h) thereto:

                  (g) within 20 days after the end of each calendar month (i) a
                  Borrowing Base Certificate showing the Borrowing Base as of
                  the close of business on the last day of such calendar month,
                  each such Borrowing Base Certificate to be certified as
                  complete and correct in all material respects on behalf of the
                  Borrower by a Responsible Officer, and (ii) such other
                  supporting documentation and additional reports with respect
                  to the Borrowing Base as the Administrative Agent shall
                  reasonably request, including, but not limited to, such
                  supporting documentation as listed in Exhibit J; provided that
                  the Borrower shall supplement the Borrowing Base Certificate
                  delivered with respect to the month ending December 31, 2000,
                  to reflect any adjustments necessary as a result of the
                  Borrower's year-end physical inventory; and

                  (h) on the first and third Friday of each calendar month, (i)
                  a cash receipts and disbursements budget updated for an 8 week
                  period and (ii) a comparison of the actual and previously
                  budgeted cash receipts and disbursements, including an
                  explanation of significant variances.

                  11. Amendment to Subsection 6.6 (Inspection of Property; Books
and Records; Discussions). Subsection 6.6 of the Credit Agreement is hereby
amended by (i) inserting subsection "(a)" prior to the first sentence thereof
and (ii) adding the following new subsection (b), subsection (c) and subsection
(d) thereto:

                  (b) The Borrower and its Subsidiaries, from time to time upon
                  the request of the Administrative Agent or the Required
                  Lenders through the Administrative Agent, shall permit the
                  Administrative Agent, accompanied by one or more Lenders and
                  professionals (including investment bankers, consultants,
                  accountants, lawyers and appraisers) retained by the
                  Administrative Agent (or its counsel) to conduct evaluations
                  and appraisals of (i) the Borrower's practices in the
                  computation of the Borrowing Base and (ii) the assets included
                  in the Borrowing Base (it being understood and agreed that the
                  Administrative Agent will conduct such evaluations and
                  appraisals not less than once per fiscal year of the Borrower)
                  and pay the reasonable fees and expenses of the Administrative
                  Agent incurred in connection therewith (including the fees and
                  expenses of the Administrative Agent's Collateral Monitoring
                  Department), the Lenders or such professionals with respect to
                  all such appraisals; provided, however, that the
<PAGE>   9
                                                                               9

                  Administrative Agent shall not be entitled to conduct such
                  evaluations and appraisals of assets more frequently than
                  twice per year unless (x) a Default or Event of Default has
                  occurred and is continuing or (y) the Administrative Agent, or
                  the Required Lenders through the Administrative Agent,
                  determines that any material event or material change has
                  occurred with respect to the Borrower or its Subsidiaries,
                  their Inventory or receivables practices or the performance of
                  the Collateral and that as a result of such event or change
                  more frequent evaluations or appraisals are required to
                  effectively monitor the Borrowing Base, in which case the
                  Borrower will permit the Administrative Agent to conduct such
                  evaluations and appraisals at such reasonable times and as
                  often (not to exceed four times per year) as may be reasonably
                  requested by the Administrative Agent.

                  (c) The Borrower will, and will cause each of its Subsidiaries
                  to, in connection with any evaluation and appraisal relating
                  to the computation of the Borrowing Base, maintain such
                  additional reserves (for purposes of computing the Borrowing
                  Base) in respect of Eligible Accounts Receivables and Eligible
                  Inventory and make such other adjustments to the parameters
                  for including Eligible Inventory in the Borrowing Base as the
                  Administrative Agent or the Required Lenders through the
                  Administrative Agent shall reasonably require based upon the
                  result of such evaluation and appraisal.

                  12. Amendment to Section 6 (Blocked Account Agreement).
Section 6 is hereby amended by adding the following new subsection 6.14:

                  6.14 Blocked Account Agreement. (i) Within 15 Business Days
                  after the Fourth Amendment Effective Date, enter into a
                  blocked account agreement with any financial institution
                  reasonably requested by the Administrative Agent at any time,
                  in a form and substance reasonably satisfactory to the
                  Administrative Agent, the Borrower and the applicable
                  financial institution; and (ii) maintain substantially all of
                  its cash with a financial institution with which it has
                  entered into a blocked account agreement.

                  13. Amendments to Subsection 7.2 (Limitations on
Indebtedness). Subsection 7.2 is hereby amended as follows:

                  (a) in clause (iv) of paragraph (b) thereof, by (1) deleting
"(x)" where it appears therein; (2) deleting "plus"; and (3) deleting clause (y)
in its entirety;

                  (b) in paragraph (c) thereof, by (i) deleting "$10,000,000 at
any time outstanding" where it appears therein and (ii) inserting, in lieu
thereof, "the aggregate amount outstanding on the Fourth Amendment Effective
Date";

                  (c) in paragraph (e) thereof, by (i) deleting "$5,000,000
pursuant to this clause (e) in aggregate principal amount at any one time
outstanding" where it appears therein and (ii) inserting, in lieu thereof, "the
aggregate principal amount outstanding on the Fourth Amendment Effective Date
plus $2,500,000";
<PAGE>   10
                                                                              10

                  (d) in paragraph (h) thereof, by (i) inserting "in an
aggregate amount not to exceed $500,000" after the words "ordinary course of
business" where such words appear therein and (ii) deleting "five" where it
appears therein and inserting, in lieu thereof, "three";

                  (e) in paragraph (k) thereof, by (i) deleting "an aggregate
principal amount of $2,000,000 per annum," where it appears therein and
inserting, in lieu thereof, "the aggregate principal amount outstanding on the
Fourth Amendment Effective Date plus $1,000,000"; and (ii) deleting the second
proviso in its entirety;

                  (f) in paragraph (l) thereof, by (i) deleting "$15,000,000 at
any time outstanding" where it appears therein and (ii) inserting, in lieu
thereof, "the amount outstanding on the Fourth Amendment Effective Date";

                  (g) in paragraph (n), by (i) deleting "$2,500,000 at any one
time outstanding", (ii) inserting, in lieu thereof, "the amount outstanding on
the Fourth Amendment Effective Date" and (iii) adding "and" at the end thereof;

                  (h) in paragraph (o) thereof, by (i) deleting "$3,000,000
where it appears therein and inserting, in lieu thereof, "$1,500,000" and (ii)
deleting "; and" where it appears after the semi-colon at the end of such
paragraph and inserting, in lieu thereof, a period mark; and

                  (i) by deleting paragraph (p) in its entirety.

                  14. Amendments to Subsection 7.6 (Limitations on Sale of
Assets). Subsection 7.6 is hereby amended by (i) deleting "$10,000,000" where it
appears in paragraph (b) thereof and (ii) inserting, in lieu thereof,
"$1,000,000".

                  15. Subsection 7.8 (Limitation on Capital Expenditures).
Subsection 7.8 is hereby amended as follows:

                  (a) (i) by deleting the semi-colon at the end of clause (iii);
(ii) by deleting the proviso that follows clause (iii) in its entirety and (iv)
by inserting, in lieu thereof, a period mark; and

                  (b) by inserting at the end thereof the following:

                  During the Amendment Period, the Borrower agrees that it shall
                  not, and shall not permit its Subsidiaries to, make Capital
                  Expenditures other than Capital Expenditures in an aggregate
                  amount not to exceed $1,000,000.

                  16. Subsection 7.9 (Limitation on Investments, Loans and
Advances). Subsection 7.9 of the Credit Agreement is hereby amended as follows:

                  (a) in clause (iv) of paragraph (d) thereof, by (1) deleting
"(x)" where it appears therein; (2) deleting "plus"; and (3) deleting clause (y)
in its entirety;

                  (b) by deleting the text in its entirety in paragraph (g)
thereof and inserting, in lieu thereof "Intentionally Omitted"; and
<PAGE>   11
                                                                              11

                  (c) in paragraph (j) thereof, by (i) deleting "plus (i)" where
it appears therein and (ii) deleting "and (ii) any Available Excess Equity
Proceeds".

                  17. Amendment to Section 10(c) (Events of Default). Section
10(c) of the Credit Agreement is hereby amended by inserting "or subsection
6.2(d)" after the words "contained in Section 7 or Section 8".

                  18. Addition of Exhibit J (Form of Borrowing Base
Certificate). A new Exhibit J to the Credit Agreement in the form of Annex A to
this Amendment shall be added to the Credit Agreement.

                  19. Certain Agreements. (a) The Borrower, the Administrative
Agent and the Lenders acknowledge and agree that, during the Amendment Period,
the Lenders shall make Extensions of Credit only to the extent that such
Extensions of Credit do not exceed the lesser of (i) the Borrowing Base and (ii)
$47,000,000.

                  (b) The Borrower hereby acknowledges and agrees that, during
the Amendment Period, the Borrower shall not, and shall not permit any of its
Subsidiaries to, make any Restricted Payments on any class of the Capital Stock
of the Borrower (other than as permitted under subsections 7.7(a), (b) and (c)
of the Credit Agreement) or make any optional payment or prepayment or
redemption, defeasance or purchase of any Senior Subordinated Notes or any other
Subordinated Indebtedness (if any) of the Borrower.

                  (c) The Borrower hereby acknowledges and agrees that, during
the Amendment Period, the Borrower shall not, and shall not permit any of its
Subsidiaries to, make any Permitted Acquisitions.

                  (d) The Borrower hereby agrees to keep the Administrative
Agent and the Lenders informed of the progress of the status of the Borrower's
discussions concerning entering into an alternative credit facility that will
replace the Credit Agreement, including, without limitation, prompt notice of
the receipt and execution of any commitment letter, the completion by the
relevant lender of its due diligence and collateral audit review, and the
setting of any closing date, or, as the case may be, the Borrower's decision not
to pursue such alternative credit facility.

                  (e) The Borrower hereby agrees to deliver a detailed budget to
the Administrative Agent, with a copy for each Lender, on or before December 31,
2000.

                  (f) Failure to comply with the agreements contained in
paragraphs (d) and (e) of this Section 19 shall constitute an Event of Default,
if such default shall continue unremedied for a period of five Business Days.

                  20. Waivers. (a) For the Amendment Period, the Administrative
Agent and the Lenders hereby waive (i) the Borrower's non-compliance with the
provisions of subsections 6.1, 6.2, 6.6 and 6.7 of the Credit Agreement, solely
insofar as such non-compliance relates to the Borrower's failure to deliver
financial statements in accordance with GAAP in respect of its 1998 and 1999
fiscal years and of periods included in its 1998, 1999 and 2000 fiscal years
<PAGE>   12
                                                                              12

through and including June 30, 2000, and (ii) the Borrower's non-compliance with
the financial covenants contained in subsection 7.1(a) and 7.1(b) of the Credit
Agreement (to the extent that there would be non-compliance with the interest
coverage ratio contained in subsection 7.1(b) of the Credit Agreement, but only
to the extent that such interest coverage ratio is not less than 2.95 to 1.00),
solely insofar as such non-compliance relates to its 1998 and 1999 fiscal years
and to fiscal quarters in its 1998, 1999 and 2000 fiscal years through and
including the fiscal quarter ended September 30, 2000, but in each case only to
the extent such non-compliance arises out of or relates to the Inventory
adjustments disclosed in Holdings' Report on Form 10-Q filed for the fiscal
quarter ended September 30, 2000.

                  (b) For the Amendment Period, the Administrative Agent and the
Lenders hereby waive the Borrower's non-compliance with the financial covenants
contained in subsection 7.1(a) and 7.1(b) of the Credit Agreement (to the extent
that (x) the leverage ratio contained in subsection 7.1(a) is not greater than
7.50 to 1.00 and (y) the interest coverage ratio contained in subsection 7.1(b)
is not less than 1.50 to 1.00), solely in so far as such non-compliance relates
to the fiscal quarter ending December 31, 2000.

                  (c) For the Amendment Period, the Administrative Agent and the
Lenders hereby waive any breach by the Borrower of any representation or
warranty made or deemed to be made by it pursuant to subsection 5.2 of the
Credit Agreement, solely insofar as such breach arises out of the matters
described in clauses (i) and (ii) of Section 20(a) of this Amendment.

                  (d) The Administrative Agent and the Lenders hereby agree that
the waivers contained in this Amendment shall have effect for purposes of
Sections 10(b), (c) and (d) of the Credit Agreement.

                  21. Conditions to Effectiveness. This Amendment shall be
effective on the date (the "Fourth Amendment Effective Date") that (a) the
Administrative Agent shall have received counterparts hereof, duly executed and
delivered by the Borrower, Holdings, the Required Lenders and the Grantors under
the Guarantee and Collateral Agreement; (b) the Administrative Agent shall have
received, for the account of each Lender which executes and delivers this
Amendment, an amendment fee in the amount equal to the product of (i) 0.25% and
(ii) such Lender's Commitment; (c) all other reasonable fees payable, including
the fees and disbursement of counsel to the Administrative Agent and the fees
and expenses incurred in connection with the retention of a financial advisor,
shall have been paid; (d) the Borrower shall have delivered to the
Administrative Agent a Borrowing Base Certificate showing the Borrowing Base as
of the close of business on October 31, 2000 and executed by a Responsible
Officer, substantially in the form of Exhibit J to the Credit Agreement, and in
a form reasonably satisfactory to the Administrative Agent, including the
appropriate insertions, attachments and schedules referred to in such Exhibit J;
and (e) no Default or Event of Default shall have occurred and be continuing on
the date hereof after giving effect to this Amendment.

                  22. Representations and Warranties. In order to induce the
Administrative Agent and the Lenders to enter into this Amendment, the Borrower
and Holdings hereby represent and warrant to the Administrative Agent and the
Lenders that the representations and warranties of the Borrower and Holdings
contained in the Loan Documents are true and correct in all material respects on
and as of the Fourth Amendment Effective Date (after giving effect hereto) as if
<PAGE>   13
                                                                              13

made on and as of the Fourth Amendment Effective Date (except where such
representations and warranties expressly relate to an earlier date in which case
such representations and warranties were true and correct in all material
respects as of such earlier date); provided that all references to the "Credit
Agreement" in any Loan Document shall be and are deemed to mean the Credit
Agreement as amended hereby.

                  23. Notice of Effectiveness. The Administrative Agent shall
promptly advise the Lenders and the Borrower of the effectiveness of this
Amendment.

                  24. Payment of Expenses. The Borrower agrees to pay or
reimburse the Administrative Agent for all of its out-of-pocket costs and
expenses incurred in connection with the development, preparation and execution
of this Amendment and any other documents prepared in connection herewith, and
the consummation and administration of the transactions contemplated hereby,
including, without limitation, the reasonable fees and disbursements of counsel
to the Administrative Agent and the reasonable fees and disbursements of the
Administrative Agent's Collateral Monitoring Department.

                  25. Counterparts. This Amendment may be executed by the
parties to this Amendment on any number of separate counterparts (which may
include counterparts delivered by facsimile transmission), and all of said
counterparts taken together shall be deemed to be one and the same instrument.
Any executed counterpart delivered by facsimile transmission shall be effective
for all purposes hereof.

                  26. Successors and Assigns. This Amendment shall be binding
upon and inure to the benefit of the Borrower and Holdings and their respective
successors and assigns, and upon the Administrative Agent and the Lenders and
their successors and assigns. The execution and delivery of this Amendment by
any Lender prior to the Fourth Amendment Effective Date shall be binding upon
its successors and assigns and shall be effective as to any loans or commitments
assigned to it after such execution and delivery.

                  27. Continuing Effect. Except as expressly amended hereby, the
Credit Agreement as amended by this Amendment shall continue to be and shall
remain in full force and effect in accordance with its terms. This Amendment
shall not constitute an amendment or waiver of any provision of the Credit
Agreement not expressly referred to herein and shall not be construed as an
amendment, waiver or consent to any action on the part of the Borrower and
Holdings that would require an amendment, waiver or consent of the
Administrative Agent or the Lenders except as expressly stated herein. Any
reference to the "Credit Agreement" in the Loan Documents or any related
documents shall be deemed to be a reference to the Credit Agreement as amended
by this Amendment.

                  28. GOVERNING LAW. THIS AMENDMENT AND THE RIGHTS AND
OBLIGATIONS OF THE PARTIES UNDER THIS AMENDMENT SHALL BE GOVERNED BY, AND
CONSTRUED AND ENFORCED IN ACCORDANCE WITH, THE LAW OF THE STATE OF NEW YORK.
<PAGE>   14
                                                                              14

                  IN WITNESS WHEREOF, the parties have caused this Amendment to
be executed and delivered by their respective duly authorized officers as of the
day and year first above written.

                                               TWINLAB CORPORATION

                                               By:_________________________
                                               Name:
                                               Title:

                                               TWIN LABORATORIES INC.

                                               By:_________________________
                                               Name:
                                               Title:

                                               THE CHASE MANHATTAN BANK as
                                               Administrative Agent,
                                               Issuing Bank, Swing Line
                                               Lender and as a Lender

                                               By:_________________________
                                               Name:
                                               Title:
<PAGE>   15
                                                     Fourth Amendment and Waiver
                                                     to the Amended and Restated
                                                  Credit and Guarantee Agreement

                                       THE BANK OF NEW YORK,
                                       as Co-Agent and as a Lender

                                       By:_________________________
                                       Name:
                                       Title:

                                       FLEETBOSTON,
                                       as a Lender

                                       By:_________________________
                                       Name:
                                       Title:

                                       DRESDNER BANK AG, NEW YORK BRANCH
                                       AND GRAND CAYMAN BRANCH,
                                       as a Lender

                                       By:_________________________
                                       Name:
                                       Title:

                                       By:_________________________
                                       Name:
                                       Title:
<PAGE>   16
                                                     Fourth Amendment and Waiver
                                                     to the Amended and Restated
                                                  Credit and Guarantee Agreement

                                       U.S. BANK NATIONAL ASSOCIATION,
                                       as a Lender

                                       By:_________________________
                                       Name:
                                       Title:

                                       EUROPEAN AMERICAN BANK,
                                       as a Lender

                                       By:_________________________
                                       Title:

                                       ERSTE BANK DER OESTERREICHISCHEN
                                       SPARKASSEN AG, GRAND CAYMAN ISLAND
                                       BRANCH, as a Lender

                                       By:_________________________
                                       Name:
                                       Title:

                                       ZIONS FIRST NATIONAL BANK,
                                       as a Lender

                                       By:_________________________
                                       Name:
                                       Title:
<PAGE>   17
                                                     Fourth Amendment and Waiver
                                                     to the Amended and Restated
                                                  Credit and Guarantee Agreement

                                       ADVANCED RESEARCH PRESS, INC.,
                                       as a Grantor

                                       By:_________________________
                                       Name:
                                       Title:

                                       BRONSON LABORATORIES, INC.,
                                       as a Grantor

                                       By:_________________________
                                       Name:
                                       Title:

                                       CHANGES INTERNATIONAL, INC.,
                                       as a Grantor

                                       By:_________________________
                                       Name:
                                       Title:

                                       HEALTH FACTORS INTERNATIONAL, INC.
                                       as a Grantor

                                       By:_________________________
                                       Name:
                                       Title:

                                       PR NUTRITION, INC.,
                                       as a Grantor

                                       By:_________________________
                                       Name:
                                       Title:

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