Document:

Exhibit

SECOND AMENDMENT TO ASSET PURCHASE AGREEMENT

THIS SECOND AMENDMENT TO ASSET PURCHASE AGREEMENT (the “Second Amendment”) is made as of April 4, 2019 (the “Effective Date”), by and between RH Cell Therapeutics Corp. (“Purchaser”) and Vital Therapies, Inc. (“Seller”). The words and terms defined in the Asset Purchase Agreement (defined below) shall have the same meaning when used in this Second Amendment unless the context expressly requires otherwise

RECITALS

A.Whereas, on March 13, 2019 Seller and Purchaser entered into an Asset Purchase Agreement (the “Asset Purchase Agreement”) in connection with a purchase and sale of certain ELAD System related assets, or the Purchased Assets, as amended by the First Amendment to Asset Purchase Agreement entered into the parties on March 27, 2019 (“First Amendment”). 

B. Whereas, Purchaser has not deposited the remaining balance of the Escrow Amount into the Escrow Account in accordance with the provisions of the Agreement, as amended by the First Amendment, and has requested additional time in order to fund the balance of the Escrow Amount.

C.Whereas, Purchaser is willing to deposit into the Escrow Account an additional $100,000 in immediately available funds upon execution of this Second Amendment.

D.Whereas, in consideration for the additional time to fund the Escrow Account Purchaser has agreed to waive the provisions of Section 5.07 of the Agreement and delete the provision from the Agreement.

AGREEMENT

NOW THEREFORE, in consideration of and in reliance upon the covenants herein contained the parties agree as follows:

1.Additional Deposit into Escrow Account. Purchaser shall, by wire transfer of immediately available funds, wire to the Escrow Agent the amount of One Hundred Thousand US Dollars ($100,000) no later than 5:00 PM PST on April 8, 2019. Failure to make the additional deposit shall be deemed a material breach of the Agreement.

2.Extension of Escrow Funding Period.   Section 2.03 of the Asset Purchase Agreement is hereby further amended to change the  date for Purchaser to wire transfer to the Escrow Agent the remaining Escrow Amount ($1,250,000, after the additional deposit), for deposit into the Escrow Account to no later than 5:00 PM PST on April 15, 2019.

3.Deletion of Section 5.07.  Section 5.07 of the Agreement is hereby deleted in its entirety and said section shall be intentionally left blank.

4.Amendment to Section 7.01. Section 7.01 of the Agreement is hereby amended to add the following clause (e):  

“(e)    by Seller if Seller elects to sell all or some of the ELAD System related assets (designated herein as Purchased Assets) to a third party.”

5.Amendment to Section 7.02.  Section 7.02 of the Agreement is hereby amended to add the following clause (d):

“(d)    In the event of a termination of this Agreement pursuant to Section 7.01(e), any Escrow Amount deposited by the Purchaser shall be refunded to the Purchaser from the Escrow Account. The Deposit shall be retained by the Seller.”

6.Other Terms of the Asset Purchase Agreement.  Except as amended herein, all other terms, covenants and conditions of Asset Purchase Agreement, shall remain in full force and effect.

7.Counterparts.  This Second Amendment may be executed in two or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. Delivery of an executed counterpart of a signature page to this Second Amendment by facsimile, portable document format (.pdf), DocuSign or other electronic transmission shall be equally as effective as delivery of a manually executed counterpart of this Second Amendment.

IN WITNESS WHEREOF, the parties hereto have executed this Second Amendment as of the Effective Date.

SELLER

Vital Therapies, Inc.

_____________________________________________
By: Duane Nash
Title: President and Chief Executive Officer

PURCHASER

RH Cell Therapeutics Corp.

                    

_____________________________________________
By: Haibin Ruan
Title: President and Chief Executive Officer 

                    

Page 1 of 2EX-4.1

 Exhibit 4.1 

Execution Version 

FIRST AMENDMENT TO REGISTRATION RIGHTS AGREEMENT 

This First Amendment to Registration Rights Agreement (this “Amendment”) is made and entered into as of
April 9, 2019 by and among Crestwood Equity Partners LP, a Delaware limited partnership (“Crestwood”), and CN Jackalope Holdings, LLC, a Delaware limited liability company (“Holdings”). Each of
Crestwood and Holdings may be referred to as a “Party” and collectively, as the “Parties.” 

Capitalized terms used herein but not otherwise defined herein shall have the meanings ascribed to them in that certain Registration Rights
Agreement, dated as of December 28, 2017 (the “Registration Rights Agreement”), by and among Crestwood and Holdings. 

RECITALS: 

WHEREAS, the Parties previously entered into the Registration Rights Agreement on December 28, 2017; 

WHEREAS, this Agreement is made in connection with the entry into the Third Amended and Restated Limited Liability Company
Agreement of Crestwood Niobrara LLC by and between Holdings, Crestwood Midstream Partners LP, and solely for the purposes of the provisions set forth therein, Crestwood (the “Company Agreement”). 

WHEREAS, in connection with the entry into the Company Agreement, Crestwood Niobrara LLC has issued 235,000,000 Series A-3 Preferred Units to Holdings; 
 WHEREAS, Crestwood has agreed to provide registration and other
rights set forth in the Registration Rights Agreement and this Amendment for the benefit of Holdings pursuant to the Company Agreement; 

WHEREAS, the parties desire to amend the Registration Rights Agreement to conform with certain provisions of the Company Agreement and
the issuance of Series A-3 Preferred Units to Holdings; 
 WHEREAS,
Section 3.12 of the Registration Rights Agreement provides that such agreement may be amended by means of a written amendment signed by Crestwood and the Holders of a majority of the then-outstanding Registrable Securities
(or the Holdings Member, to the extent that no Registrable Securities have been issued). 
 NOW, THEREFORE, in consideration
of the mutual covenants and agreements set forth herein and for good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged by each party hereto, the parties hereby agree as follows: 

Section 1.    Amendments to Registration Rights Agreement 

(a)    Definitions. The following definitions are hereby amended and restated in their entirety in
Section 1.01 of the Registration Rights Agreement: 
 ““Company Agreement” means the Third
Amended and Restated Limited Liability Company Agreement of Crestwood Niobrara LLC by and between Holdings, Crestwood Midstream Partners LP, and solely for the purposes of the provisions set forth therein, Crestwood.” 

 ““Redemption Units” means the CEQP Units to be issued to Holdings
Member pursuant to Sections 3.05, 4.06(b), 4.06(c), 4.06(d), 4.06(e) or 4.06(f) of the Company Agreement.” 

““Trigger Event” means the delivery of (i) written notice from Crestwood Member that it is making an election
pursuant to Section 3.05(a) of the Company Agreement to pay any portion of the Crestwood Floor Price in CEQP Units; (ii) a Consideration Election Notice from Crestwood Member indicating that Crestwood Member has
elected to acquire all or a portion of the then outstanding Series A Preferred Units and Series B Preferred Units through the issuance of CEQP Units in accordance with Section 4.06(b) or
Section 4.06(c) of the Company Agreement; (iii) a Crestwood Full Redemption Notice from Crestwood Member that it is making an election pursuant to Section 4.06(d)(2) of the Company Agreement;
(iv) a Crestwood Partial Redemption Notice from Crestwood Member that it is making an election pursuant to Section 4.06(e)(2) of the Company Agreement; (v) written notice from Crestwood Member that it is making an
election pursuant to Section 4.06(f)(2) of the Company Agreement; or (vi) written notice from Crestwood Member or Holdings that the cash proceeds of an Asset Sale are less than the redemption price and require the
issuance of CEQP Units to Holdings under any of Sections 4.06(c), 4.06(d), 4.06(e) or 4.06(f) of the Company Agreement.” 

(b)    Amendments to Sections. 

i.    Section 2.03 is hereby amended and restated as follows: 

Demand Rights. Holdings shall have the right, at any time from time to time, to elect to include, other than pursuant to
Section 2.02 of this Agreement, (i) at least an aggregate of $40.0 million of Registrable Securities (calculated based on the product of the CEQP Unit Price times the number of Registrable Securities) or (ii) a lesser amount of
Registrable Securities if the same consists of all CEQP Units that were issued to the Holdings Member in connection with a transaction contemplated by Sections 3.05(a), 4.06(b), 4.06(c), 4.06(d), 4.06(e) or
4.06(f) of the Company Agreement (excluding a partial redemption under Section 4.06(f)), under a registration statement pursuant to an Underwritten Offering, pursuant to and subject to the conditions of this
Section 2.03 of this Agreement, exercisable by delivery of a written notice to Crestwood (an “Underwritten Offering Notice”); provided, however, that such right shall not be exercised (i) in respect of more than two Underwritten
Offerings or (ii) more than once in 

  
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any 180 day period, provided further, however, notwithstanding the foregoing, as of any date of determination, the aggregate number of Underwritten Offerings available as of such date shall be
increased by one upon each occurrence of redemption of less than all of the Series A Preferred Units then outstanding that are owned by Holdings in which CEQP Units are issued as consideration for all or a portion of such redemption pursuant to
Section 4.06(e) of the Company Agreement. Upon the delivery to Crestwood of any Underwritten Offering Notice, Crestwood shall be obligated to retain underwriters in order to permit Holdings to effect such sale through an
Underwritten Offering. In connection with any Underwritten Offering under this Section 2.03, Holdings shall be entitled to select the Managing Underwriter or Underwriters for such Underwritten Offering, subject to the consent of Crestwood not
to be unreasonably withheld, delayed or conditioned. 
 ii.    Section 3.01(c) is hereby amended and
restated as follows: 
 if to Crestwood: 

Crestwood Midstream Partners LP 

811 Main St., Suite 3400 

Houston, TX 77002 
 Attention:
Joel Lambert 
 Facsimile: (832) 519-2250 

Email: Joel.Lambert@crestwoodlp.com 

with a copy to: 

Vinson & Elkins L.L.P. 

1001 Fannin, Suite 2500 

Houston, Texas 77002 

Attention: Gillian Hobson 

Facsimile: (713) 615-5883 

Email: ghobson@velaw.com 

All such notices and communications shall be deemed to have been received at the time delivered by hand, if personally
delivered; when receipt acknowledged, if sent via facsimile or sent via Internet electronic mail; and when actually received, if sent by courier service or any other means. 

Section 2.    General Provisions. 

(a)    Amendment. No amendment of this Amendment shall be valid unless such amendment is made in accordance with
Section 3.12 of the Registration Rights Agreement. 

  
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 (b)    Counterparts. This Amendment may be executed in several
counterparts, and all so executed shall constitute one agreement, binding on all the parties hereto, even though all parties are not a signatory to the original or the same counterpart. 

(c)    Governing Law. The parties agree that this Amendment shall be governed by, and construed and enforced in
accordance with, the laws of the State of Delaware, without application of the conflict of laws principles thereof. 

(d)    Severability of Provisions. Any provision of this Amendment that is prohibited or unenforceable in any
jurisdiction shall, as to such jurisdiction, be ineffective to the extent of such prohibition or unenforceability without invalidating the remaining provisions hereof or affecting or impairing the validity or enforceability of such provision in any
other jurisdiction. 
 (e)    Effect of the Amendment. Except as amended by this Amendment, all other terms of
the Registration Rights Agreement shall continue in full force and effect and remain unchanged and are hereby confirmed in all respects by each party. 

[Signature Page Follows] 

  
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 IN WITNESS WHEREOF, the parties hereto execute this Amendment, effective as of the date
first written above. 
  

			
	COMPANY:
	
	CRESTWOOD EQUITY PARTNERS LP
		
	By:	 	Crestwood Equity GP LLC, its general partner
		
	By:	 	 /s/ William Moore

	Name:	 	William Moore
	Title:	 	Senior Vice President, Strategy & Corporate Development

 SIGNATURE PAGE TO 

FIRST AMENDMENT TO REGISTRATION RIGHTS AGREEMENT 

 
			
	CN JACKALOPE HOLDINGS, LLC
		
	By:	 	GIP JACKALOPE ACQUISITION PARTNERS, L.P.,
	its Administrative Agent
		
	By:	 	GLOBAL INFRASTRUCTURE GP CASCADE I, L.P.,
	its general partner
		
	By:	 	GLOBAL INFRASTRUCTURE INVESTORS CASCADE, LLC,
	its general partner

 
			
		
	By:	 	 /s/ Matthew Harris

	Name:	 	Matthew Harris
	Title:	 	Partner

 SIGNATURE PAGE TO 

FIRST AMENDMENT TO REGISTRATION RIGHTS AGREEMENT

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