Document:

exv10w196w1

 

Exhibit 10.196.1

AMENDMENT NO. 1 TO

 WARRANT AGREEMENT

     THIS AMENDMENT NO. 1 (this “Amendment”) dated as of February 28, 2006 to the WARRANT
AGREEMENT (the “Agreement”) dated as of February 9, 2006 by and between The Immune Response
Corporation, a Delaware corporation (the “Company”), and Spencer Trask Intellectual Capital
Company, LLC (the “Warrant Holder”).

     The parties hereto, intending to be legally bound hereby, agree that the Agreement is hereby
amended as follows:

     1. The first WHEREAS clause of the Agreement is hereby deleted in its entirety.

     2. The second WHEREAS clause of the Agreement is hereby deleted in its entirety and replaced
with the following:

     WHEREAS, the Company has executed a certain Security Agreement, dated as of February 9, 2006
(the “Security Agreement”), in favor of Hudson Asset Partners, LLC, a Delaware limited liability
company (the “Agent”), acting in its capacity as agent for the holders of 8% senior secured
convertible promissory notes (the “Convertible Notes”) to be issued by the Company pursuant to a
certain Confidential Private Placement Memorandum (the “Offering”); and

     3. The third WHEREAS clause of the Agreement is hereby deleted in its entirety and replaced
with the following:

     WHEREAS, pursuant to a certain Limited Recourse Interest Agreement dated as of February 9,
2006, as amended as of February 28, 2006, by the Warrant Holder in favor of the Agent the Warrant
Holder has agreed that in the event the assets of the Company subject to the Security Agreement are
insufficient to satisfy the obligations of the Company to specified investors (the “Investors”) in
the Offering who hold Convertible Notes up to an aggregate maximum principal amount of $6,000,000
(the “Notes”) upon an event of default under the Notes, the Warrant Holder will provide certain
support for the obligations of the Company to the Investors, and the Company has agreed to issue to
the Warrant Holder warrants (the “Warrants”) to purchase shares of the Company’s common stock, par
value $.0025 per share (the “Common Stock”), subject to the terms set forth herein.

     4. (a) The Agreement shall remain in full force and effect, subject only to the changes
expressly set forth herein.

          (b) The Agreement, as modified by this Amendment, the Notes and the other agreements and
documents referenced herein or in the Agreement set forth the

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entire agreement of the parties with
respect to the subject matter thereof and supersede all previous understandings, written or oral,
in respect thereof.

          (c) All references to the Agreement in any other documents or otherwise shall mean the
Agreement as amended by this Amendment and from time to time hereafter in writing.

          (d) This Amendment shall be governed by the laws of the State of New York, without regard to
the principles of conflicts of laws of such state.

          (e) This Amendment may be executed in counterparts and each of such counterparts shall for
all purposes be deemed to be an original, and such counterparts shall together constitute one and
the same instrument.

[Remainder of page intentionally left blank]

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     IN WITNESS WHEREOF, the parties hereto have duly executed this Amendment as of the date
first above written.

	 	 	 	 	 	 	 
	 	 	SPENCER TRASK INTELLECTUAL CAPITAL COMPANY, LLC	 	 
	 
	 	 	 	 	 	 
	 

	 	By:	 	 	 	 
	 

	 	 	 	 	 	 
	 

	 	Name:	 	 	 	 
	 

	 	Title:	 	 	 	 
	 
	 	 	 	 	 	 
	 	 	THE IMMUNE RESPONSE CORPORATION	 	 
	 
	 	 	 	 	 	 
	 

	 	By:	 	 	 	 
	 

	 	 	 	 	 	 
	 

	 	Name:	 	 	 	 
	 

	 	Title:	 	 	 	 

3exv10w197

 

Exhibit 10.197

REGISTRATION RIGHTS AGREEMENT

     This Registration Rights Agreement (the “Agreement”) is made and entered into as of this 22nd
day of February, 2006 by and among The Immune Response Corporation, a Delaware corporation (the
“Company”), Spencer Trask Ventures, Inc., a Delaware corporation (the “Placement Agent”), and
certain accredited investors purchasing 8% senior secured convertible promissory notes (the
"Notes”) and warrants (the “Warrants”) to purchase shares of common stock, par value $.0025 per
share, of the Company (the “Common Stock”) offered in private placement (the “Offering”) by the
Company. Such investors are each referred to herein as a “Purchaser” and, collectively, as the
“Purchasers”.

     WHEREAS, in connection with certain Subscription Agreements among the Investors and the
Company (the “Subscription Agreements”) which have been executed in connection with the
consummation of the transactions contemplated in that certain Confidential Private Placement
Memorandum dated February 9, 2006 (the “Memorandum”), the Company has agreed, upon the terms and
subject to the conditions of the Subscription Agreements and the Memorandum, to issue and sell to
the Investors an aggregate of up to 50 units ($5,000,000), with each unit (a “Unit” or “Units”)
consisting of a Note in the principal amount of $100,000 convertible into shares of Common Stock
(the “Conversion Shares”) at a conversion price of $0.02 per share of Common Stock and a Warrant to
purchase 15,000,000 shares of Common Stock, exercisable at $0.02 per share of Common Stock (the
“Warrant Shares”);

     WHEREAS, to induce the Investors to execute and deliver the Subscription Agreement, the
Company has agreed to provide certain registration rights with respect to the Conversion Shares and
the Warrant Shares on the terms and conditions provided herein;

     WHEREAS, the Company has agreed to provide certain registration rights with respect to the
shares (the “Placement Agent Warrant Shares”) of Common Stock issuable upon exercise of warrants
issued to the Placement Agent and its permitted transferees (the “Placement Agent Warrants”) in
connection with the transactions contemplated by the Memorandum on the terms and conditions
provided herein; and

     WHEREAS, the Company has agree to provide certain registration rights with respect to the
shares (the “STIC Shares”) of Common Stock issuable upon exercise of warrants issued to Spencer
Trask Intellectual Capital Company, LLC and its permitted transferees (the “STIC Warrants”) in
connection with the transactions contemplated by the Memorandum on the terms and conditions provide
herein.

     NOW, THEREFORE, for good and valuable consideration, the parties hereby agree as follows:

     1. Certain Definitions.

     As used in this Agreement, the following terms shall have the following meanings:

     “Affiliate” means, with respect to any person, any other person which directly or
indirectly controls, is controlled by, or is under common control with, such person.

     “Business Day” means a day, other than a Saturday or Sunday, on which banks in New
York City are open for the general transaction of business.

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     “Common Stock” as defined in the Preamble.

     “Investors” means the Purchasers purchasing Registrable Securities pursuant to the
Subscription Agreements, the Placement Agent and any Affiliate or permitted transferee of any
Purchaser or the Placement Agent who is a subsequent holder of any Registrable Securities.

     “Memorandum” as defined in the Preamble.

     “Offering” as defined in the Preamble.

     “Placement Agent Warrants” as defined in the Preamble.

     “Placement Agent Warrant Shares” as defined in the Preamble.

     “Prospectus” means the prospectus included in any Registration Statement, as amended
or supplemented by any prospectus supplement, with respect to the terms of the offering of any
portion of the Registrable Securities covered by such Registration Statement and by all other
amendments and supplements to the prospectus, including post-effective amendments and all material
incorporated by reference in such prospectus.

     “Register,” “registered” and “registration” refer to a registration
made by preparing and filing a Registration Statement or similar document in compliance with the
1933 Act (as defined below), and the declaration or ordering of effectiveness of such Registration
Statement or document.

     “Registrable Securities” shall mean (i) the Conversion Shares, (ii) the Warrant
Shares, (iii) the Placement Agent Warrant Shares, (iv) the STIC Shares and (v) any other securities
issued or issuable with respect to or in exchange for Registrable Securities; provided,
that, a security shall cease to be a Registrable Security upon (A) sale pursuant to a Registration
Statement or Rule 144 under the 1933 Act, or (B) such security becoming eligible for sale by the
Investors pursuant to Rule 144(k) under the 1933 Act.

     “Registration Statement” shall mean any registration statement of the Company filed
under the 1933 Act that covers the resale of any of the Registrable Securities pursuant to the
provisions of this Agreement, amendments and supplements to such Registration Statement, including
post-effective amendments, all exhibits and all material incorporated by reference in such
Registration Statement.

     “Required Investors” means the Investors holding a majority of the Registrable
Securities.

     “SEC” means the U.S. Securities and Exchange Commission.

     “Shares” means the shares of Common Stock sold in the Offering.

     “STIC Shares” as defined in the Preamble.

     “STIC Warrants” as defined in the Preamble.

     “Subscription Agreement” as defined in the Preamble.

     “1933 Act” means the Securities Act of 1933, as amended, and the rules and regulations
promulgated thereunder.

     “1934 Act” means the Securities Exchange Act of 1934, as amended, and the rules and
regulations promulgated thereunder.

     “Warrants” as defined in the Preamble.

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     “Warrant Shares” as defined in the Preamble.

     2. Registration.

               (a) Registration Statements.

               (i) Promptly following the final closing of the purchase and sale of the securities
contemplated by the Memorandum (the “Closing Date”) but no later than forty-five (45) days after
the Closing Date (the “Filing Deadline”), the Company shall prepare and file with the SEC one
Registration Statement on Form S-3 (or, if Form S-3 is not then available to the Company, on such
form of registration statement as is then available to effect a registration for resale of the
Registrable Securities, subject to the Required Investors’ consent), covering the sale or the
resale of the Registrable Securities in an amount at least equal to the Conversion Shares, the
Warrant Shares and the Placement Agent Warrant Shares; provided, however, that in
the event that the SEC (A) does not allow the filing of such Registration Statement, (B) notifies
the Company that it will not review such Registration Statement in a normal time period or (C)
requests the withdrawal of such Registration Statement, in each case because at the time of such
attempted filing the Company did not have enough authorized shares of Common Stock to register
(each an “SEC Dismissal”), then the Company shall file such Registration Statement within ten (10)
business days after receiving approval of its stockholders for an amendment to its certificate of
incorporation to increase its authorized shares of Common Stock (the “Dismissal Deadline”). Such
Registration Statement shall include a plan of distribution, which shall be substantially in the
form attached hereto as Exhibit A. Such Registration Statement shall also cover, to the
extent allowable under the 1933 Act and the rules promulgated thereunder (including Rule 416), such
indeterminate number of additional shares of Common Stock resulting from stock splits, stock
dividends or similar transactions with respect to the Registrable Securities. The Registration
Statement (and each amendment or supplement thereto, and each request for acceleration of
effectiveness thereof) shall be provided in accordance with Section 3(c) to the Investors and their
counsel prior to its filing or other submission. If a Registration Statement covering the
Registrable Securities is not filed with the SEC on or prior to the Filing Deadline or the
Dismissal Deadline, as applicable, the Company will make pro rata payments to each Investor, as
liquidated damages and not as a penalty, in an amount equal to 1.0% of the aggregate amount
invested by such Investor for each 30-day period or pro rata for any portion thereof following the
Filing Deadline or Dismissal Deadline, as applicable, for which no Registration Statement is filed
with respect to the Registrable Securities. Such payments shall be in partial compensation to the
Investors, and shall not constitute the Investors’ exclusive remedy for such events. Such payments
shall be made to each Investor in cash or additional shares of Common Stock, as determined by each
Investor, and shall be paid monthly within three (3) Business Days after the last day of each month
following the Filing Deadline.

               (ii) Additional Registrable Securities. Upon the written demand of any Investor and
upon any change in the Exercise Price (as defined in the Warrants and the Placement Agent Warrants,
respectively) such that additional shares of Common Stock become issuable upon the exercise of the
Warrants and/or Placement Agent Warrants, the Company shall prepare and file with the SEC one or
more Registration Statements on Form S-3 or amend or supplement the Registration Statement filed
pursuant to clause (i) above, if such Registration Statement has not previously been declared
effective (or, if Form S-3 is not then available to the Company, on such form of registration
statement as is then available to effect a registration for

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resale of such additional shares of Common Stock (the “Additional Shares”), subject to the
Required Investors’ consent, covering the sale or the resale of the Additional Shares, but only to
the extent the Additional Shares are not at the time covered by an effective Registration
Statement. Such Registration Statement also shall cover, to the extent allowable under the 1933
Act and the rules promulgated thereunder (including Rule 416), such indeterminate number of
additional shares of Common Stock resulting from stock splits, stock dividends or similar
transactions with respect to the Additional Shares. The Registration Statement (and each amendment
or supplement thereto, and each request for acceleration of effectiveness thereof) shall be
provided in accordance with Section 3(c) to the Investors and their counsel prior to its filing or
other submission. If a Registration Statement covering the Additional Shares is required to be
filed under this Section 2(a)(ii) and is not filed with the SEC within five (5) Business Days after
the request of any Investor or the occurrence of any of the events specified in this Section
2(a)(ii), but in no event earlier than the Filing Deadline, (the “Additional Shares Deadline”),
then the Company will, for each 30-day period or pro rata for any portion thereof following the
date by which such Registration Statement should have been filed for which no Registration
Statement is filed with respect to the Additional Shares, make pro rata payments to each Investor,
as liquidated damages and not as a penalty, in an amount equal to 1.0% of the prorated aggregate
amount invested by such Investor and that is attributable to the Additional Shares. By way of
example only, if an Investor purchased Registrable Securities representing 300,000 shares and
subsequently received 100,000 Additional Shares, the liquidated damages due on passage of the
Additional Shares Deadline would be calculated with reference to one-quarter of the total amount
invested by that Investor (i.e., 100,000/400,000, where 400,000 is calculated by adding 100,000 and
300,000). Such payments shall be in partial compensation to the Investors, and shall not
constitute the Investors’ exclusive remedy for such events. Such payments shall be made to each
Investor in cash or additional shares of Common Stock, as determined by each Investor, and shall be
paid monthly within three (3) Business Days after the last day of each month following the
Additional Shares Deadline.

               (iii) S-3 Qualification. If the Company is not eligible to use a registration
statement on Form S-3 as provided in Sections 2(a)(i) and 2(a)(ii) above, then, promptly following
the date (the “Qualification Date”) upon which the Company becomes eligible to use a registration
statement on Form S-3 to register the Registrable Securities or Additional Shares, as applicable,
for resale, but in no event more than forty-five (45) days after the Qualification Date (the
“Qualification Deadline”), the Company shall file a registration statement on Form S-3 covering the
Registrable Securities or Additional Shares, as applicable (or a post-effective amendment on Form
S-3 to the registration statement on Form S-1) (a “Shelf Registration Statement”) and shall use
commercially reasonable efforts to cause such Shelf Registration Statement to be declared effective
as promptly as practicable thereafter. If a Shelf Registration Statement covering the Registrable
Securities is not filed with the SEC on or prior to the Qualification Deadline, the Company will
make pro rata payments to each Investor, as liquidated damages and not as a penalty, in an amount
equal to 1.0% of the aggregate amount invested by such Investor for each 30-day period or pro rata
for any portion thereof following the date by which such Shelf Registration Statement should have
been filed for which no such Shelf Registration Statement is filed with respect to the Registrable
Securities or Additional Shares, as applicable. Such payments shall be in partial compensation to
the Investors, and shall not constitute the Investors’ exclusive remedy for such events. Such
payments shall be made to each Investor in cash or additional shares of Common Stock, as determined
by each Investor, and shall be paid monthly within three (3) Business Days after the last day of
each month following the Qualification Deadline.

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               (b) Expenses. The Company will pay all expenses associated with each registration,
including filing and printing fees, the Company’s counsel and accounting fees and expenses, costs
associated with clearing the Registrable Securities for sale under applicable state securities
laws, listing fees, and fees and reasonable expenses of one counsel to the Investors. Other than
the above, the Investors shall bear their respective expenses in connection with the registration,
including, without limitation, discounts, commissions, fees of underwriters, selling brokers,
dealer managers or similar securities industry professionals with respect to the Registrable
Securities being sold.

               (c) Effectiveness.

               (i) The Company shall use commercially reasonable efforts to have the Registration Statement
declared effective as soon as practicable. The Company shall notify the Investors by facsimile or
e-mail as promptly as practicable, and in any event, within twenty-four (24) hours, after any
Registration Statement is declared effective and shall simultaneously provide the Investors with
copies of any related Prospectus to be used in connection with the sale or other disposition of the
securities covered thereby. If (A)(x) a Registration Statement covering the Registrable Securities
is not declared effective by the SEC prior to the earlier of (i) ten (10) Business Days after the
SEC has notified the Company that no review of the Registration Statement will be made or (ii)
within ninety (90) days after the Filing Deadline or the Dismissal Deadline (if applicable), (y) a
Registration Statement covering Additional Shares is not declared effective by the SEC within
ninety (90) days after the Additional Shares Deadline or (z) a Shelf Registration Statement is not
declared effective by the SEC within ninety (90) days after the Qualification Deadline, or (B)
after a Registration Statement has been declared effective by the SEC, sales cannot be made
pursuant to such Registration Statement for any reason (including without limitation by reason of a
stop order, or the Company’s failure to update the Registration Statement), but excluding the
inability of any Investor to sell the Registrable Securities covered thereby due to market
conditions and except as excused pursuant to subparagraph (ii) below, then the Company will make
pro rata payments to each Investor, as liquidated damages and not as a penalty, in an amount equal
to 1.0% of the aggregate amount invested by such Investor for each 30-day period or pro rata for
any portion thereof following the date by which such Registration Statement should have been
effective (the “Blackout Period”). Such payments shall be in partial compensation to the
Investors, and shall not constitute the Investors’ exclusive remedy for such events. The amounts
payable as liquidated damages pursuant to this paragraph shall be paid monthly within three (3)
Business Days after the last day of each month following the commencement of the Blackout Period
until the termination of the Blackout Period. Such payments shall be made to each Investor in cash
or in additional shares of Common Stock as determined by each Investor.

               (ii) For not more than twenty (20) consecutive days or for a total of not more than forty-five
(45) days in any twelve (12) month period, the Company may delay the disclosure of material
non-public information concerning the Company, by suspending the use of any Prospectus included in
any registration contemplated by this Section containing such information, the disclosure of which
at the time is not, in the good faith opinion of the Company, in the best interests of the Company
(an “Allowed Delay”); provided, that the Company shall promptly (a) notify the Purchasers
and the Placement Agent in writing of the existence of (but in no event, without the prior written
consent of a Purchaser and the Placement Agent, shall the Company disclose to such Investor any of
the facts or circumstances regarding) material non-public information giving rise to an Allowed
Delay, (b) advise the Purchasers and the Placement

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Agent in writing to cease all sales under the Registration Statement until the end of the
Allowed Delay and (c) use commercially reasonable efforts to terminate an Allowed Delay as promptly
as practicable.

               3. Company Obligations. The Company will use commercially reasonable efforts to
effect the registration of the Registrable Securities in accordance with the terms hereof, and
pursuant thereto the Company will, as expeditiously as possible:

               (a) use commercially reasonable efforts to cause such Registration Statement to become
effective and to remain continuously effective for a period that will terminate upon the earlier of
(i) the date on which all Registrable Securities covered by such Registration Statement as amended
from time to time, have been sold, and (ii) the date on which all Registrable Securities covered by
such Registration Statement may be sold pursuant to Rule 144(k) (the “Effectiveness Period”) and
advise the Investors in writing when the Effectiveness Period has expired;

               (b) prepare and file with the SEC such amendments and post-effective amendments to the
Registration Statement and the Prospectus as may be necessary to keep the Registration Statement
effective for the period specified in Section 3(a) and to comply with the provisions of the 1933
Act and the 1934 Act with respect to the distribution of all of the Registrable Securities covered
thereby;

               (c) provide copies to and permit counsel designated by the Investors to review each
Registration Statement and all amendments and supplements thereto no fewer than seven (7) days
prior to their filing with the SEC and not file any document to which such counsel reasonably
objects at least 24 hours prior to the filing of such Registration Statement, amendments or
supplements with the SEC;

               (d) furnish, upon request of the Investors, one (1) copy of any Registration Statement and any
amendment thereto, each preliminary prospectus and Prospectus and each amendment or supplement
thereto, and each letter written by or on behalf of the Company to the SEC or the staff of the SEC,
and each item of correspondence from the SEC or the staff of the SEC, in each case relating to such
Registration Statement (other than any portion of any thereof which contains information for which
the Company has sought confidential treatment), and (ii) such number of copies of a Prospectus,
including a preliminary prospectus, and all amendments and supplements thereto and such other
documents as each Investor may reasonably request in order to facilitate the disposition of the
Registrable Securities owned by such Investor that are covered by the related Registration
Statement;

               (e) use commercially reasonable efforts to (i) prevent the issuance of any stop order or other
suspension of effectiveness and, (ii) if such order is issued, obtain the withdrawal of any such
order at the earliest possible moment;

               (f) prior to any public offering of Registrable Securities, use commercially reasonable
efforts to register or qualify or cooperate with the Investors and their counsel in connection with
the registration or qualification of such Registrable Securities for offer and sale under the
securities or blue sky laws of such jurisdictions requested by the Investors and do any and all
other commercially reasonable acts or things necessary or advisable to enable the distribution in
such jurisdictions of the Registrable Securities covered by the Registration Statement;
provided, however, that the Company shall not be required in

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connection therewith or as a condition thereto to (i) qualify to do business in any
jurisdiction where it would not otherwise be required to qualify but for this Section 3(f), (ii)
subject itself to general taxation in any jurisdiction where it would not otherwise be so subject
but for this Section 3(f), or (iii) file a general consent to service of process in any such
jurisdiction;

               (g) use commercially reasonable efforts to cause all Registrable Securities covered by a
Registration Statement to be listed on each securities exchange, interdealer quotation system or
other market on which similar securities issued by the Company are then listed;

               (h) immediately notify the Investors, at any time when a Prospectus relating to Registrable
Securities is required to be delivered under the 1933 Act, upon discovery that, or upon the
happening of any event as a result of which, the Prospectus included in a Registration Statement,
as then in effect, includes an untrue statement of a material fact or omits to state any material
fact required to be stated therein or necessary to make the statements therein not misleading in
light of the circumstances then existing, and at the request of any such holder, promptly prepare
and furnish to such holder a reasonable number of copies of a supplement to or an amendment of such
Prospectus as may be necessary so that, as thereafter delivered to the purchasers of such
Registrable Securities, such Prospectus shall not include an untrue statement of a material fact or
omit to state a material fact required to be stated therein or necessary to make the statements
therein not misleading in light of the circumstances then existing; and

               (i) otherwise use commercially reasonable efforts to comply with all applicable rules and
regulations of the SEC under the 1933 Act and the 1934 Act, take such other actions as may be
reasonably necessary to facilitate the registration of the Registrable Securities hereunder; and
make available to its security holders, as soon as reasonably practicable, but not later than the
Availability Date (as defined below), an earnings statement covering a period of at least twelve
(12) months, beginning after the effective date of each Registration Statement, which earnings
statement shall satisfy the provisions of Section 11(a) of the 1933 Act, including Rule 158
promulgated thereunder (for the purpose of this subsection 3(i), “Availability Date” means the 45th
day following the end of the fourth fiscal quarter that includes the effective date of such
Registration Statement, except that, if such fourth fiscal quarter is the last quarter of the
Company’s fiscal year, “Availability Date” shall mean the 90th day after the end of such fourth
fiscal quarter); provided, however, that the filing of any such earnings statement
in a periodic report filed with the SEC shall satisfy the Company’s obligations under this Section
3(i).

               (j) With a view to making available to the Investors the benefits of Rule 144 (or its
successor rule) and any other rule or regulation of the SEC that may at any time permit the
Investors to sell shares of Common Stock to the public without registration, the Company covenants
and agrees to: (i) make and keep public information available, as those terms are understood and
defined in Rule 144, until the earlier of (A) six months after such date as all of the Registrable
Securities may be resold pursuant to Rule 144(k) or any other rule of similar effect or (B) such
date as all of the Registrable Securities shall have been resold; (ii) file with the SEC in a
timely manner all reports and other documents required of the Company under the 1934 Act; and (iii)
furnish to each Investor upon request, as long as such Investor owns any Registrable Securities,
(A) a written statement by the Company that it has complied with the reporting requirements of the
1934 Act, (B) a copy of the Company’s most recent Annual Report on Form 10-K or Quarterly Report on
Form 10-Q, and (C) such other information as may be

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reasonably requested in order to avail such Investor of any rule or regulation of the SEC that
permits the selling of any such Registrable Securities without registration.

     4. Due Diligence Review; Information. The Company shall make available, during normal
business hours, for inspection and review by the Investors, advisors to and representatives of the
Investors (who may or may not be affiliated with the Investors and who are reasonably acceptable to
the Company), all financial and other records, all SEC filings, and all other corporate documents
and properties of the Company as may be reasonably necessary for the purpose of such review, and
cause the Company’s officers, directors and employees, within a reasonable time period, to supply
all such information reasonably requested by the Investors or any such representative, advisor or
underwriter in connection with such Registration Statement (including, without limitation, in
response to all questions and other inquiries reasonably made or submitted by any of them), prior
to and from time to time after the filing and effectiveness of the Registration Statement for the
sole purpose of enabling the Investors and such representatives, advisors and underwriters and
their respective accountants and attorneys to conduct initial and ongoing due diligence with
respect to the Company and the accuracy of such Registration Statement.

          The Company shall not disclose material nonpublic information to the Investors, or to advisors
to or representatives of the Investors, unless prior to disclosure of such information the Company
identifies such information as being material nonpublic information and provides the Investors,
such advisors and representatives with the opportunity to accept or refuse to accept such material
nonpublic information for review and any Investor wishing to obtain such information enters into an
appropriate confidentiality agreement with the Company with respect thereto.

     5. Obligations of the Investors.

               (a) Each Investor shall furnish in writing to the Company such information regarding itself,
the Registrable Securities held by it and the intended method of disposition of the Registrable
Securities held by it, as shall be reasonably required to effect the registration of such
Registrable Securities and shall execute such documents in connection with such registration as the
Company may reasonably request. At least five (5) Business Days prior to the first anticipated
filing date of any Registration Statement, the Company shall notify each Investor of the
information the Company requires from such Investor if such Investor elects to have any of the
Registrable Securities included in the Registration Statement. An Investor shall provide such
information to the Company at least two (2) Business Days prior to the first anticipated filing
date of such Registration Statement if such Investor elects to have any of the Registrable
Securities included in the Registration Statement.

               (b) Each Investor, by its acceptance of the Registrable Securities agrees to cooperate with
the Company as reasonably requested by the Company in connection with the preparation and filing of
a Registration Statement hereunder, unless such Investor has notified the Company in writing of its
election to exclude all of its Registrable Securities from such Registration Statement.

               (c) Each Investor agrees that, upon receipt of any notice from the Company of either (i) the
commencement of an Allowed Delay pursuant to Section 2(c)(ii) or (ii) the happening of an event
pursuant to Section 3(h) hereof, such Investor will immediately discontinue disposition of
Registrable Securities pursuant to the Registration Statement covering

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such Registrable Securities, until the Investor’s receipt of the copies of the supplemented or
amended prospectus filed with the SEC and until any related post-effective amendment is declared
effective and, if so directed by the Company, the Investor shall deliver to the Company (at the
expense of the Company) or destroy (and deliver to the Company a certificate of destruction) all
copies in the Investor’s possession of the Prospectus covering the Registrable Securities current
at the time of receipt of such notice.

     6. Indemnification.

               (a) Indemnification by the Company. The Company will indemnify and hold harmless each
Investor and their respective officers, directors, members, employees and agents, successors and
assigns, and each other person, if any, who controls such Investor within the meaning of the 1933
Act, against any losses, claims, damages or liabilities, joint or several, to which they may become
subject under the 1933 Act or otherwise, insofar as such losses, claims, damages or liabilities (or
actions in respect thereof) arise out of or are based upon: (i) any untrue statement or alleged
untrue statement of any material fact contained in any Registration Statement, any preliminary
prospectus or final prospectus contained therein, or any amendment or supplement thereof; (ii) any
blue sky application or other document executed by the Company specifically for that purpose or
based upon written information furnished by the Company filed in any state or other jurisdiction in
order to qualify any or all of the Registrable Securities under the securities laws thereof; (iii)
the omission or alleged omission to state therein a material fact required to be stated therein or
necessary to make the statements therein not misleading; (iv) any violation by the Company or its
agents of any rule or regulation promulgated under the 1933 Act applicable to the Company or its
agents and relating to action or inaction required of the Company in connection with such
registration; or (v) any failure to register or qualify the Registrable Securities included in any
such Registration in any state where the Company or its agents has affirmatively undertaken or
agreed in writing that the Company will undertake such registration or qualification on an
Investor’s behalf and will reimburse such Investor, and each such officer, director or member and
each such controlling person for any legal or other expenses reasonably incurred by them in
connection with investigating or defending any such loss, claim, damage, liability or action;
provided, however, that the Company will not be liable in any such case if and to
the extent that any such loss, claim, damage or liability arises out of or is based upon an untrue
statement or alleged untrue statement or omission or alleged omission so made in conformity with
information furnished by such Investor or any such controlling person in writing specifically for
use in such Registration Statement or Prospectus.

               (b) Indemnification of the Company. Each Investor agrees, severally but not jointly,
to indemnify and hold harmless, to the fullest extent permitted by law, the Company, its directors,
officers, employees, stockholders and each person who controls the Company (within the meaning of
the 1933 Act) against any losses, claims, damages, liabilities and expense (including reasonable
attorney fees) resulting from any untrue statement of a material fact or any omission of a material
fact required to be stated in the Registration Statement or Prospectus or preliminary prospectus or
amendment or supplement thereto or necessary to make the statements therein not misleading, to the
extent, but only to the extent that such untrue statement or omission is contained in any
information furnished in writing by such Investor to the Company specifically for inclusion in such
Registration Statement or Prospectus or amendment or supplement thereto. In no event shall the
liability of an Investor be greater in amount than the dollar amount of the proceeds (net of all
expense paid by such Investor in

9

 

connection with any claim relating to this Section 6 and the amount of any damages such
Investor has otherwise been required to pay by reason of such untrue statement or omission)
received by such Investor upon the sale of the Registrable Securities included in the Registration
Statement giving rise to such indemnification obligation.

               (c) Conduct of Indemnification Proceedings. Any person entitled to indemnification
hereunder shall (i) give prompt notice to the indemnifying party of any claim with respect to which
it seeks indemnification and (ii) permit such indemnifying party to assume the defense of such
claim with counsel reasonably satisfactory to the indemnified party; provided, that any
person entitled to indemnification hereunder shall have the right to employ separate counsel and to
participate in the defense of such claim, but the fees and expenses of such counsel shall be at the
expense of such person unless (a) the indemnifying party has agreed to pay such fees or expenses,
or (b) the indemnifying party shall have failed to assume the defense of such claim and employ
counsel reasonably satisfactory to such person or (c) in the reasonable judgment of any such
person, based upon written advice of its counsel, a conflict of interest exists between such person
and the indemnifying party with respect to such claims (in which case, if the person notifies the
indemnifying party in writing that such person elects to employ separate counsel at the expense of
the indemnifying party, the indemnifying party shall not have the right to assume the defense of
such claim on behalf of such person); and provided, further, that the failure of
any indemnified party to give notice as provided herein shall not relieve the indemnifying party of
its obligations hereunder, except to the extent that such failure to give notice shall materially
adversely affect the indemnifying party in the defense of any such claim or litigation. It is
understood that the indemnifying party shall not, in connection with any proceeding in the same
jurisdiction, be liable for fees or expenses of more than one separate firm of attorneys at any
time for all such indemnified parties. No indemnifying party will, except with the consent of the
indemnified party, consent to entry of any judgment or enter into any settlement that does not
include as an unconditional term thereof the giving by the claimant or plaintiff to such
indemnified party of a release from all liability in respect of such claim or litigation.

               (d) Contribution. If for any reason the indemnification provided for in the preceding
paragraphs (a) and (b) is unavailable to an indemnified party or insufficient to hold it harmless,
other than as expressly specified therein, then the indemnifying party shall contribute to the
amount paid or payable by the indemnified party as a result of such loss, claim, damage or
liability in such proportion as is appropriate to reflect the relative fault of the indemnified
party and the indemnifying party, as well as any other relevant equitable considerations. No
person guilty of fraudulent misrepresentation within the meaning of Section 11(f) of the 1933 Act
shall be entitled to contribution from any person not guilty of such fraudulent misrepresentation.
In no event shall the contribution obligation of a holder of Registrable Securities be greater in
amount than the dollar amount of the proceeds (net of all expenses paid by such holder in
connection with any claim relating to this Section 6 and the amount of any damages such holder has
otherwise been required to pay by reason of such untrue or alleged untrue statement or omission or
alleged omission) received by it upon the sale of the Registrable Securities giving rise to such
contribution obligation.

     7. Miscellaneous.

               (a) Amendments and Waivers. This Agreement may be amended only by a writing signed by
the Company and the Required Investors. The Company may take any

10

 

action herein prohibited, or omit to perform any act herein required to be performed by it,
only if the Company shall have obtained the written consent to such amendment, action or omission
to act, of the Required Investors.

               (b) Notices. All notices and other communications provided for or permitted hereunder
shall be made in accordance with the provisions of the Subscription Agreement or the Placement
Agent Warrants, as applicable.

               (c) Assignments and Transfers by Investors. The provisions of this Agreement shall be
binding upon and inure to the benefit of the Investors and their respective successors and assigns.
An Investor may transfer or assign, in whole or from time to time in part, to one or more persons
its rights hereunder in connection with the transfer of Registrable Securities by such Investor to
such person, provided that such Investor complies with all laws applicable thereto and provides
written notice of assignment to the Company promptly after such assignment is effected.

               (d) Assignments and Transfers by the Company. This Agreement may not be assigned by
the Company (whether by operation of law or otherwise) without the prior written consent of the
Required Investors, provided, however, that the Company may assign its rights and delegate its
duties hereunder to any surviving or successor corporation in connection with a merger or
consolidation of the Company with another corporation, or a sale, transfer or other disposition of
all or substantially all of the Company’s assets to another corporation, without the prior written
consent of the Required Investors, after notice duly given by the Company to each Investor.

               (e) Benefits of the Agreement. The terms and conditions of this Agreement shall inure
to the benefit of and be binding upon the respective permitted successors and assigns of the
parties. Nothing in this Agreement, express or implied, is intended to confer upon any party other
than the parties hereto or their respective successors and assigns any rights, remedies,
obligations, or liabilities under or by reason of this Agreement, except as expressly provided in
this Agreement.

               (f) Counterparts; Faxes. This Agreement may be executed in two or more counterparts,
each of which shall be deemed an original, but all of which together shall constitute one and the
same instrument. This Agreement may also be executed via facsimile, which shall be deemed an
original.

               (g) Titles and Subtitles. The titles and subtitles used in this Agreement are used
for convenience only and are not to be considered in construing or interpreting this Agreement.

               (h) Severability. Any provision of this Agreement that is prohibited or unenforceable
in any jurisdiction shall, as to such jurisdiction, be ineffective to the extent of such
prohibition or unenforceability without invalidating the remaining provisions hereof but shall be
interpreted as if it were written so as to be enforceable to the maximum extent permitted by
applicable law, and any such prohibition or unenforceability in any jurisdiction shall not
invalidate or render unenforceable such provision in any other jurisdiction. To the extent
permitted by applicable law, the parties hereby waive any provision of law which renders any
provisions hereof prohibited or unenforceable in any respect.

11

 

               (i) Further Assurances. The parties shall execute and deliver all such further
instruments and documents and take all such other actions as may reasonably be required to carry
out the transactions contemplated hereby and to evidence the fulfillment of the agreements herein
contained.

               (j) Entire Agreement. This Agreement is intended by the parties as a final expression
of their agreement and intended to be a complete and exclusive statement of the agreement and
understanding of the parties hereto in respect of the subject matter contained herein. This
Agreement supersedes all prior agreements and understandings between the parties with respect to
such subject matter.

               (k) Governing Law; Consent to Jurisdiction; Waiver of Jury Trial. This Agreement
shall be governed by, and construed in accordance with, the internal laws of the State of New York
without regard to the choice of law principles thereof. Each of the parties hereto irrevocably
submits to the exclusive jurisdiction of the courts of the State of New York located in New York
County and the United States District Court for the Southern District of New York for the purpose
of any suit, action, proceeding or judgment relating to or arising out of this Agreement and the
transactions contemplated hereby. Service of process in connection with any such suit, action or
proceeding may be served on each party hereto anywhere in the world by the same methods as are
specified for the giving of notices under this Agreement. Each of the parties hereto irrevocably
consents to the jurisdiction of any such court in any such suit, action or proceeding and to the
laying of venue in such court. Each party hereto irrevocably waives any objection to the laying of
venue of any such suit, action or proceeding brought in such courts and irrevocably waives any
claim that any such suit, action or proceeding brought in any such court has been brought in an
inconvenient forum. EACH OF THE PARTIES HERETO WAIVES ANY RIGHT TO REQUEST A TRIAL BY JURY IN ANY
LITIGATION WITH RESPECT TO THIS AGREEMENT AND REPRESENTS THAT COUNSEL HAS BEEN CONSULTED
SPECIFICALLY AS TO THIS WAIVER.

[remainder of page intentionally left blank]

12

 

          IN WITNESS WHEREOF, the parties have executed this Agreement or caused their duly authorized
officers to execute this Agreement as of the date first above written.

	 	 	 	 	 	 	 
	The Company:	 	THE IMMUNE RESPONSE CORPORATION	 	 
	 
	 	 	 	 	 	 
	 

	 	By:	 	 	 	 
	 

	 	 	 	 	 	 
	 	 	Name:	 	 
	 	 	Title:	 	 
	 
	 	 	 	 	 	 
	The Placement Agent:	 	SPENCER TRASK VENTURES, INC.	 	 
	 
	 	 	 	 	 	 
	 

	 	By:	 	 	 	 
	 

	 	 	 	 	 	 
	 	 	Name: William P. Dioguardi	 	 
	 	 	Title: President	 	 

The Purchasers:     [Contained in Omnibus Signature Page in Subscription Agreement]

13

 

Exhibit A

Plan of Distribution

     The selling stockholders (the “Selling Stockholders”, which as used herein includes donees,
pledgees, transferees or other successors-in-interest of a Selling Stockholder selling shares of
Common Stock or interests in shares of Common Stock received after the date of this prospectus from
a Selling Stockholder as a gift, pledge, partnership distribution or other transfer) may, from time
to time, sell, transfer or otherwise dispose of any or all of their shares of Common Stock or
interests in shares of Common Stock on any stock exchange, market or trading facility on which the
shares are traded or in private transactions. These dispositions may be at fixed prices, at
prevailing market prices at the time of sale, at prices related to the prevailing market price, at
varying prices determined at the time of sale, or at negotiated prices.

     The Selling Stockholders may use any one or more of the following methods when disposing of
shares or interests therein:

     – ordinary brokerage transactions and transactions in which the broker-dealer solicits
purchasers;

     – block trades in which the broker-dealer will attempt to sell the shares as agent, but may
position and resell a portion of the block as principal to facilitate the transaction;

     – purchases by a broker-dealer as principal and resale by the broker-dealer for its account;

     – an exchange distribution in accordance with the rules of the applicable exchange;

     – privately negotiated transactions;

     – short sales effected after the date the registration statement of which this Prospectus is a
part is declared effective by the SEC;

     – through the writing or settlement of options or other hedging transactions, whether through
an options exchange or otherwise;

     – broker-dealers may agree with the Selling Stockholders to sell a specified number of such
shares at a stipulated price per share; and

     – a combination of any such methods of sale.

     The Selling Stockholders may, from time to time, pledge or grant a security interest in some
or all of the shares of Common Stock owned by them and, if they default in the performance of their
secured obligations, the pledgees or secured parties may offer and sell the shares of Common Stock,
from time to time, under this Prospectus, or under an amendment to this Prospectus under Rule
424(b)(3) or other applicable provision of the 1933 Act amending the list of Selling Stockholders
to include the pledgee, transferee or other successors-in-interest as Selling Stockholders under
this Prospectus. The Selling Stockholders also may transfer the shares of Common Stock in other
circumstances, in which case the transferees, pledgees or other successors-in-interest will be the
selling beneficial owners for purposes of this Prospectus.

14

 

     Broker-dealers engaged by the Selling Stockholders may arrange for other brokers-dealers to
participate in sales. Broker-dealers may receive commissions or discounts from the Selling
Stockholders (or, if any broker-dealer acts as agent for the purchaser of shares, from the
purchaser) in amounts to be negotiated. The Selling Stockholders do not expect these commissions
and discounts to exceed what is customary in the types of transactions involved.

     Spencer Trask Ventures, Inc. (“STVI”) has indicated to us its willingness to act as selling
agent on behalf of the Selling Stockholders named in the Prospectus under “Selling Security
Holders” that purchased our privately placed securities. All shares sold, if any, on behalf of
Selling Stockholders by STVI would be in transactions executed by STVI on an agency basis and
commissions charged to its customers in connection with each transaction shall not exceed a maximum
of 5% of the gross proceeds. STVI does not have an underwriting agreement with us and/or the
Selling Stockholders and no Selling Stockholders are required to execute transactions through STVI.
In the event that there are other broker-dealer firms involved in the distribution of securities
on behalf of the Selling Stockholders, the maximum commission or discount to be received will not
be greater than 8% of the sale of any securities which were registered pursuant to this Prospectus
under SEC Rule 415.

     In connection with the sale of our Common Stock or interests therein, the Selling Stockholders
may enter into hedging transactions with broker-dealers or other financial institutions, which may
in turn engage in short sales of the common stock in the course of hedging the positions they
assume. The Selling Stockholders may also sell shares of our Common Stock short and deliver these
securities to close out their short positions, or loan or pledge the Common Stock to broker-dealers
that in turn may sell these securities. The Selling Stockholders may also enter into option or
other transactions with broker-dealers or other financial institutions or the creation of one or
more derivative securities which require the delivery to such broker-dealer or other financial
institution of shares offered by this Prospectus, which shares such broker-dealer or other
financial institution may resell pursuant to this Prospectus (as supplemented or amended to reflect
such transaction).

     The Selling Stockholders will receive the aggregate proceeds from the sale of the Common Stock
offered by them. The aggregate proceeds to the Selling Stockholders from the sale of the Common
Stock offered by them will be the purchase price of the Common Stock less discounts or commissions,
if any. Each of the Selling Stockholders reserves the right to accept and, together with their
agents from time to time, to reject, in whole or in part, any proposed purchase of Common Stock to
be made directly or through agents. We will not receive any of the proceeds from the sale of
Common Stock in this offering. We may receive proceeds from holders who exercise their warrants
and pay the applicable cash exercise price in connection with those exercises.

     The Selling Stockholders also may resell all or a portion of the shares in open market
transactions in reliance upon Rule 144 under the Securities Act of 1933, provided that they meet
the criteria and conform to the requirements of that rule.

     The Selling Stockholders and any underwriters, broker-dealers or agents that participate in
the sale of the Common Stock or interests therein may be “underwriters” within the meaning of
Section 2(11) of the 1933 Act. Any discounts, commissions, concessions or profit they earn on any
resale of the shares may be underwriting discounts and commissions under the 1933 Act.

15

 

Selling Stockholders who are “underwriters” within the meaning of Section 2(11) of the 1933 Act
will be subject to the prospectus delivery requirements of the 1933 Act.

     To the extent required, the shares of our Common Stock to be sold, the names of the Selling
Stockholders, the respective purchase prices and public offering prices, the names of any agent,
dealer or underwriter, any applicable commissions or discounts with respect to a particular offer
will be set forth in an accompanying prospectus supplement or, if appropriate, a post-effective
amendment to the registration statement that includes this Prospectus.

     In order to comply with the securities laws of some states, if applicable, the Common Stock
may be sold in these jurisdictions only through registered or licensed brokers or dealers. In
addition, in some states the Common Stock may not be sold unless it has been registered or
qualified for sale or an exemption from registration or qualification requirements is available and
is complied with.

     We have advised the Selling Stockholders that the anti-manipulation rules of Regulation M
under the 1934 Act may apply to sales of shares in the market and to the activities of the Selling
Stockholders and their affiliates. In addition, we will make copies of this Prospectus (as it may
be supplemented or amended from time to time) available to the Selling Stockholders for the purpose
of satisfying the prospectus delivery requirements of the 1933 Act. The Selling Stockholders may
indemnify any broker-dealer that participates in transactions involving the sale of the shares of
Common Stock against certain liabilities, including liabilities arising under the 1933 Act.

     We will pay all of the expenses incident to registration other than commissions, fees and
discounts of underwriters, brokers, dealers and agents. We will pay for offering expenses
including the SEC registration fee, accounting fees, legal fees, printing expenses and other
related miscellaneous expenses. We have agreed to indemnify the Selling Stockholders against
liabilities, including liabilities under the 1933 Act and state securities laws, relating to the
registration of the shares offered by this Prospectus.

     We have agreed with the Selling Stockholders to keep the registration statement of which this
Prospectus constitutes a part effective until the earlier of (1) such time as all of the shares
covered by this Prospectus have been disposed of pursuant to and in accordance with the
registration statement or (2) the date on which the shares may be sold pursuant to Rule 144(k) of
the 1933 Act. Notwithstanding anything contained herein to the contrary, an aggregate of ___
shares of Common Stock issuable upon exercise of warrants held by “associated persons” of STVI are
subject to a 180 day lock-up agreement in accordance with the requirements of NASD Rule 2710(g)(1).

16

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