Document:

exv10w11

 

Exhibit 10.11

Amendment dated July 19th, 2005 to the Agreement dated March 29, 2005 regarding Protocol
Number 03-CoFactor, for Services provided by Pharm-Olam International Ltd. to Adventrx

     In compliance with Section 25.3 of the Agreement, both Adventrx Pharmaceuticals, Inc.,
and Pharm-Olam International Ltd., agree that the following provisions are binding amendments to
that Agreement:

     Section 4.9. As part of its monitoring duties outlined in Schedule 2 to this Agreement,
Pharm-Olam will visit each clinical site no less than once a month. Pharm-Olam’s reporting
regarding the monitoring visit shall be provided to Adventrx no later than three weeks from the
site visit. Request for payment due Pharm-Olam regarding monitoring visits and associated expenses
shall not be made until Adventrx received the above noted reporting.

     Section 6.2. All supporting documentation evidencing payments due under Schedule 3 shall be
in English, or shall include an accurate English translation summary, and be attached to requests
for payment of invoices.

     Section 6.2.1. Receipts and other documentation evidencing amounts due from Adventrx
as outlined in the ‘Estimated Pass Through Costs” table in Schedule 3 must be submitted to
Adventrx within 75 days of occurrence of the cost eligible for payment.

SIGNED by /s/ John Hovre

For and on behalf of Pharm-Olam International Ltd., in the presence of:

Witness:
Shari Milligan [print]

Signature: /s/ Shari Milligan

Name: Shari Milligan

Occupation:
Executive Administrator

Address: 450 N. Sam Houston Pkwy.

Suite 250

Houston, TX 77060

 

 

SIGNED
by /s/ Carrie Carlander

For and on behalf of Adventrx Pharmaceuticals, Inc.,

in the presence of:

Witness:
Beth Marion [print]

Signature: /s/ Beth Marion

Name: Beth Marion

Occupation:
Office Manager

Address: 6725 Mesa Ridge Rd #100

San Diego, CA 92121exv10w13

 

Exhibit
10.13

FIRST AMENDMENT TO LEASE

THIS
FIRST AMENDMENT TO LEASE IS MADE AND ENTERED INTO THIS
12TH
DAY OF MAY 2005, BY AND
BETWEEN GEORGE V. CASEY & ELLEN M. CASEY, TRUSTEES OF THE CASEY FAMILY TRUST DATED JUNE 22, 1998
(“LESSOR”) AND ADVENTRX PHARMACEUTICALS, INC., A DELAWARE CORPORATION (“LESSEE”)

RECITALS

WHEREAS, on June 3, 2004, George V. Casey & Ellen M. Casey (“Lessor”) and Adventrx Pharmaceuticals,
Inc. (“Lessee”), entered into that certain lease agreement (“Lease”) for leased premises consisting
of approximately 8,865 rentable square feet (“rsf”) on the first floor of that certain office
building (“Building”) located at 3725 Mesa Ridge Road, Suite 100, San Diego, California, 92121; and

WHEREAS, Lessor wishes to provide for an increase in the area of the Existing Premises, by adding
thereto the area known as 6275 Mesa Ridge Road, Suite 102, consisting of approximately 3,173 rsf
(the “Expansion Premises”) as depicted on the attached Exhibit A. The entire area of Premises
occupied by Lessee shall now contain approximately 12,038 rsf.

WHEREAS, the lease for the Existing Premises is scheduled to expire on August 31, 2009 (the
“Existing Premises Lease Expiration Date”).

NOW, THEREFORE, in consideration of the foregoing and intending to be legally bound, Lessor and
Lessee agree as follows:

1. COMMENCEMENT DATE AND DELIVERY OF THE EXPANSION PREMISES. The Commencement Date for
the Expansion Premises (“Expansion Premise Commencement Date”) shall be June 15, 2005.
Delivery of the Premises shall refer only to that portion of the Premises known a 6725 Mesa
Ridge Road, Suite 102. The estimated Delivery of the Expansion Premises (the “Expansion
Premises Delivery Date”) shall be the date on which Lessor delivers the Premises to Lessee,
subject to the terms and conditions of Sections 3.2 and 3.3 (Early Possession and Delay in
Possession), and shall occur upon: a) full execution of this First Amendment; b) delivery of a
check in the amount of $7,833.28 for Initial Monthly Base Rent (June 15 – June 30, 2005) and
Security Deposit for the Expansion Premises; and c) evidence of liability insurance coverage
for the Expansion Premises. Such Early Possession shall be subject to all provisions of the
Lease excluding payment of Monthly Base Rent for such period (however not Lessee’s share of
Operating Expenses).

2. EXPANSION PREMISES. Lessor leases to Lessee and Lessee hires from Lessor for a term
beginning on the Expansion Premises Commencement Date and ending on August 31, 2009, the
Expansion Premises on all of the terms and conditions of the Lease; provided, however, that
monthly Base Rent for the entire Premises shall be as set forth in Paragraph 3 below.

          The following table confirms the area of the Premises:

	 	 	 	 	 
	Area of Premises	 	RSF	 
	Existing Premises – 6725 Mesa Ridge Road, Suite 100
	 	 	8,865	 
	Expansion Premises – 6725 Mesa Ridge Road, Suite 102
	 	 	3,173	 
	Total Rentable Square Feet
	 	 	12,038	 

	 	3.	 	MONTHLY BASE RENT. The flowing table sets forth the revised schedule of the monthly
Base Rent (net of utilities and Operating Expenses) payable for both the Exhibiting Premises
and the Expansion Premises:

	 	 	 	 	 	 	 	 	 
	Month of Term	 	No. of	 	 	 	 	 	 
	 	 	Months	 	Existing 	 	Expansion	 	Total Monthly 
	 	 	Payable	 	Premises	 	Premises	 	Base Rent
	June 1, 2005 – June 31, 2005
	 	1	 	$14,627.25	 	$2,459.08	 	$17,086.33
	June 1, 2005 – August 31, 2005
	 	2	 	$14,627.25	 	$4,918.15	 	$19,545.40
	Sept 1, 2005 – August 31, 2006
	 	12	 	$15,066.08	 	$4,918.15	 	$19,984.23
	Sept 1, 2006 – August 31, 2007
	 	12	 	$15,518.05	 	$5,065.70	 	$20,583.75
	Sept 1, 2007 – August 31, 2008
	 	12	 	$15,983.60	 	$5,217.67	 	$21,201.27
	Sept 1, 2008 – August 31, 2009
	 	12	 	$16,463.10	 	$5,374.20	 	$21,837.30

 

 

4. TENANT IMPROVEMENTS. Prior to September 1, 2005, Lessee shall cause nonstructural,
permanent improvements to be made to the interior of the Premises, using building standard
materials, such as painting, carpet cleaning and the installation of ceiling tiles and voice
and data cabling (“the “Improvements”), which Improvements shall be performed in a good and
workmanlike manner. Provided Lessee is not in default under this Lease, Lessor shall reimburse
Lessee up to %5,000 for the cost of such Improvements. The Improvements shall not include any
partitions or other personal property of Lessee. The cost of the Improvements shall be the
reasonable charges of third parties, unrelated to Lessee, for the construction of the
Improvements.

          Not more often than once each calendar month and upon (i) receipt of copies of invoices paid by
Lessee for the Upgrades and Improvements, along with appropriate mechanics lien waivers for said
invoices and (ii) Lessor’s approval of the Upgrades and Improvements constructed thus far,
Lessor shall pay Lessee ninety percent (90%) of the total of said invoices. After October 15,
2005, provided Lessor has (i) received copies of invoices paid by Lessee totaling $5,000 for the
Improvements, along with appropriate mechanics lien waivers for said invoices and (ii) all
Upgrades and Improvements have been complete to Lessor’s reasonable satisfaction, Lessor shall
pay Lessee the remaining ten percent (10%) of such invoices if no mechanic’s lien or stop notice
claims have been made in connection with the Upgrades or Improvements. The forgoing
notwithstanding, nothing herein shall require Lessor to pay more than $5,000 for the cost of the
Improvements. Any cost of the Upgrades or Improvements in excess of those amounts shall be paid
by Lessee.

          All plans and contracts for the Upgrades and Improvements and the contractor(s) selected to
constructed the Upgrades and Improvements shall be subject to Lessor’s prior approval, which
approval will not be unreasonably withheld.

5. OPERATING EXPENSES AND OTHER AREA DEPENDENT TERMS. On the Effective Date, Lessee’s
Share of Operating Expenses (as such term is defined in Section 1.6 of the Lease) shall be
increased by 9.77% for a total of 37.29% Lessee shall continue to pay Lessee’s Share of
Operating Expenses as set forth in Section 4.2 of the Lease.

6. PARKING. As a result of the addition of the Expansion Premises, on the Expansion
Premises Commencement Date, Lessee’s parking spaces shall be increased by twelve (12) spaces
to a total of forty-two (42) parking spaces. All parking shall be on a non-reserved basis.

7. SECURITY DEPOSIT. As a result of the addition of the Expansion Premise, concurrent
with Lessee’s execution and delivery of this First Amendment to Lessor, Lessee shall deposit
with Lessor an additional amount of $5,374.20 as an increase in the Security Deposit, with a
new total of $54,763.50, to be held by Lessor.

No Waiver: Lessor’s agreement to this Amendment is specifically conditioned upon the
agreement of Lessee that by entering into this Agreement, Lessor shall not charge, relinquish or
waive any of the Lessor’s rights under the Lease, except as specifically stated herein. Lessee
hereby agrees that no act or omission of Lessor as of the date hereof, including, but no limited to
Lessor’s agreement to the Amendment, constitutes or has resulted in a waiver of any or Lessor’s
rights or a breach of Lessor’s duties under the Lease.

ALL OF THE OTHER TERMS AND CONDITIONS OF THE ABOVE DESCRIBED LEASE SHALL REMAIN IN FULL FORCE AND
EFFECT EXCEPT AS MAY BE MODIFED HEREIN.

LESSOR: GEORGE V. CASEY & ELLEN M. CASEY, TRUSTEES OF THE CASEY FAMILY TRUST DATED JUNE 22, 1998

	 	 	 	 	 
	By:

	 	[ILLEGIBLE]
	 	 
	 

	 	 	 	 
	Title:

	 	[ILLEGIBLE]
	 	 
	 

	 	 	 	 
	Date:

	 	6/1/05
	 	 
	 

	 	 	 	 

LESSEE: ADVENTRX PHARMACEUTICALS, INC, A DELAWARE CORPORATION

	 	 	 	 	 	 	 
	By:

	 	[ILLEGIBLE]
	 	By:
	 	[ILLEGIBLE]
	 

	 	 
	 	 	 	 
	Title:

	 	[ILLEGIBLE]
	 	Title:
	 	[ILLEGIBLE]
	 

	 	 
	 	 	 	 
	Date:

	 	5/26/05
	 	Date:
	 	6/1/05
	 

	 	 
	 	 	 	 

2

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