Document:

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                                                                   EXHIBIT 10.15

                               FIRST AMENDMENT TO
                    OPTION AGREEMENT AND ESCROW INSTRUCTIONS

      This FIRST AMENDMENT TO OPTION AGREEMENT AND ESCROW INSTRUCTIONS
("AMENDMENT") is made and effective as of May 25, 2001 ("EFFECTIVE DATE"), by
DIVERSIFIED EASTGATE VENTURE, an Illinois general partnership ("SELLER"), and
ILLUMINA, INC., a Delaware corporation ("BUYER"), with reference to the facts
set forth below.

                                    RECITALS:

      A. Pursuant to that certain Option Agreement and Escrow Instructions dated
July 6, 2000 ("OPTION AGREEMENT"), Seller granted to Buyer an option ("OPTION")
to purchase certain real property located in the County of San Diego,
California, as more particularly described therein ("PROPERTY"). On or about
November 30, 2000, Buyer exercised its Option to purchase the Property.

      B. Seller and Buyer have also entered into that certain Eastgate Pointe
Lease dated July 6, 2000 ("Lease") whereby Seller, as "Landlord", leased to
Buyer, as "Tenant", the Property. Under Section 4 of the Eastgate Lease, Seller
is obligated to construct certain "Project Work" according to the "Project
Plans" (as such terms are defined in the Lease). Section 4 of the Lease also
discusses the parties' obligations with respect to the construction of the
Tenant Improvements according to the Tenant Improvement Plans (as defined in the
Lease).

      C. Buyer has requested certain additions and modifications to the Project
Plans and the Project Work under the Option Agreement, which modifications
include those relating to the construction of a covered courtyard ("Covered
Courtyard"), as set forth in the plans and specifications prepared by Pacific
Cornerstone Architects dated May 10, 2001 ("Covered Courtyard Plans"). As of the
Effective Date, the estimated cost for the Covered Courtyard, including both
hard and soft costs, is approximately Two Million Two Hundred Three Thousand
Three Hundred Ninety Eight Dollars ($2,203,398). The parties acknowledge and
agree that payment for all costs and expenses incurred in connection with the
Covered Courtyard ("Covered Courtyard Costs") shall be Buyer's sole obligation
and shall be paid as provided herein.

      D. Buyer has also requested certain additions and modifications to the
Tenant Improvements Plans and the Tenant Improvements under the Lease, which
modifications include those relating to the construction of certain additional
improvements in Building A and Building B and the construction of two mechanical
enclosures (collectively, the "Additional Tenant Improvements"), as set forth in
the plans and specifications prepared by Pacific Cornerstone Architects dated
April 9, 2001 and the plans for the Mechanical Enclosure dated May 7, 2001
(collectively, the "Revised Tenant Improvement Plans"). As of the Effective
Date, the estimated cost for the Additional Tenant Improvements, including both
hard and soft costs, is approximately One Million Six Hundred Seventy Eight
Thousand Six Hundred Thirty Seven Dollars ($1,678,637), which amount is in
excess of the Tenant Improvement Allowance (as defined in the Lease). The
parties acknowledge and agree that payment for all costs and

<PAGE>   2

expenses incurred in connection with the Additional Tenant Improvements
("Additional Tenant Improvement Costs") shall be Buyer's sole obligation and
shall be paid as provided herein.

      E. The parties desire to enter into this Amendment to provide for the
method of payment of the Covered Courtyard Costs and the Additional Tenant
Improvement Costs (collectively, the "Additional Improvement Costs"), on the
terms and conditions set forth herein.

      NOW THEREFORE, in consideration of the foregoing recitals, and for other
good and valuable consideration, the receipt and sufficiency of which are hereby
acknowledged, the parties agree as set forth below.

      1. Covered Courtyard Costs.

         (a) Seller hereby approves the construction of the Covered Courtyard
according to the Covered Courtyard Plans. The parties acknowledge and agree that
the Covered Courtyard shall be constructed pursuant to a separate construction
agreement executed by and between Buyer and Bearing Construction, Inc.
("Contractor"). The parties further agree that all Covered Courtyard Costs shall
be Buyer's sole obligation. Buyer shall pay the Covered Courtyard Costs to
Seller on an invoice-by-invoice basis, as such costs are invoiced to Seller by
Contractor, and such amounts shall then be paid to Contractor by Seller. Such
costs shall be paid to Seller by Buyer within ten (10) days after receiving an
invoice therefore from Seller. Any additional modifications or costs related to
the Project Work and/or the Covered Courtyard must be approved in writing in
advance by Seller.

         (b) The parties further acknowledge and agree that the addition of the
Covered Courtyard shall not increase the Rentable Area of the Premises for
purposes of calculating the Tenant Improvement Allowance pursuant to Section
4(d) of the Lease.

      2. Additional Tenant Improvement Costs. Seller hereby approves the changes
to the Revised Tenant Improvement Plans. The parties acknowledge and agree that
the Additional Tenant Improvements shall be constructed pursuant to a separate
construction agreement executed by and between Buyer and Contractor. The parties
further agree that all Additional Tenant Improvement Costs shall be Buyer's sole
obligation. Buyer's payment of the Additional Tenant Improvement Costs shall be
made by one of the following methods, which shall be determined in Seller's sole
and absolute discretion:

         (a) An amount equal to the Additional Tenant Improvement Costs shall be
deposited with Seller's construction lender, Washington Capital Joint Master
Trust Mortgage Income Fund, or its designee or assignee ("Lender") on or before
the date for deposit required by Lender. Such amounts shall be disbursed to
Seller and subsequently to Contractor as provided in the Construction Loan
Agreement dated September 26, 2000 ("Loan Agreement");

         (b) In lieu of depositing the amount of the Additional Tenant
Improvement Costs with the Lender, and beginning with the construction draw next
payable to Seller from Lender after the Effective Date, Buyer shall pay the
amount of the Additional Tenant Improvement Costs directly to Seller in place of
the construction draws otherwise to be paid by Lender to Seller under the Loan
Agreement. Such amounts shall be paid to Seller on an invoice-by-invoice basis,
within ten (10) days after receiving an invoice therefore from Seller, up to the

                                      -2-
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total amount of the Additional Tenant Improvement Costs. Seller shall then pay
Contractor directly for such costs.

      Any additional modifications or costs related to the Tenant Improvements
must be approved in writing in advance by Seller. Any payments actually received
by Seller under this Section 2 shall not be added to the Development Costs or
the Purchase Price described in Section 2.1 of the Option Agreement.

      3. Purchase Price and Net Proceeds Realized by Seller. The parties
acknowledge and agree that in no event shall the net proceeds realized by Seller
under the Option Agreement be reduced by the cost of any additional work or
improvements made to the Property at the request of Buyer, including, without
limitation, the Covered Courtyard Costs and the Additional Tenant Improvement
Costs. At Seller's election, and if Seller reasonably deems it to be necessary
in order to give effect to the foregoing intent of the parties, an amount equal
to the cost of any additional work or improvements made to the Property at the
request of Buyer, including any portion of the Additional Tenant Improvement
Costs or the Covered Courtyard Costs not actually paid by Buyer under Section 2
above, may be added to the Development Costs specified in Section 2.1 of the
Option Agreement, and the Purchase Price for the Property shall be increased
accordingly.

      4. Amendment. Except as expressly amended or modified by the provisions
and conditions of this Amendment, the Option Agreement shall remain in full
force and effect.

      5. Defined Terms. Capitalized Terms which are not otherwise defined herein
shall have the meanings attributed to them in Option Agreement.

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      6. Counterparts. This Amendment may be executed in counterparts.

      IN WITNESS WHEREOF, the parties have executed this Amendment as of the
date set forth above.

<TABLE>
        <S>                       <C>
        SELLER:                   DIVERSIFIED EASTGATE VENTURE,
                                  an Illinois general partnership

                                  By:    Diversified Eastgate Pointe, LLC,
                                         a California limited liability company,
                                         Its General Partner

                                         By: /s/ WILLIAM P. TSCHANTZ
                                            -------------------------
                                         Its:  Manager

                                  By:    GFBP Partners, LLC,
                                         a California limited liability company,
                                         Its General Partner

                                         By: /s/ WILLIAM P. TSCHANTZ
                                            -------------------------
                                         Its:  Manager

        BUYER:                    ILLUMINA, INC.,
                                  a Delaware corporation

                                  By: /s/ TIMOTHY M. KISH
                                     ---------------------------
                                  Name:   Timothy M. Kish
                                  Title:  Vice President and CFO
</TABLE>

                                      -4-
<PAGE>   5

                                CONSENT OF LENDER

      The undersigned, as "Lender" under that certain Construction Loan
Agreement dated September 26, 2000, hereby consents to the terms and conditions
of the foregoing First Amendment to Option Agreement and Escrow Instructions.

<TABLE>
<S>                                <C>
Date: May 28, 2001          WASHINGTON CAPITAL JOINT MASTER
                                   TRUST MORTGAGE INCOME FUND

                                   By:    Washington Capital Management, Inc., A
                                          Washington corporation, its Investment
                                          Manager

                                          By:    /s/ DONALD R. MAESCHER
                                             ----------------------------------
                                          Name:  Donald R. Maescher
                                          Title: President, California Division
</TABLE>

                                      -5-<PAGE>   1

                                           *** Text Omitted and Filed Separately
                                                Confidential Treatment Requested
                                          Under 17 C.F.R. Sections 200.80(b)(4),
                                                            200.83 and 240.24B-2

                                  EXHIBIT 10.88

                         NON-EXCLUSIVE LICENSE AGREEMENT

THIS NON-EXCLUSIVE LICENSE AGREEMENT (the "Agreement") is entered into as of
June 25, 2001 (the "Effective Date"), by and between EPIMMUNE INC., a
corporation organized under the laws of the State of Delaware, having offices at
5820 Nancy Ridge Drive, San Diego, California 92121 ("Epimmune"), and PHARMEXA
A/S, a company organized under the laws of Denmark, having offices at Kogle Alle
6, 2970 Horsholm, Denmark ("Pharmexa"). Epimmune and Pharmexa may each be
referred to herein individually as a "Party" and collectively as the "Parties."

        WHEREAS, Epimmune has developed and owns the PADRE(R)(as defined below)
technology; and

        WHEREAS, Pharmexa wishes to obtain, and Epimmune is willing to grant, a
non-exclusive license under the Licensed Technology (as defined below) to make,
have made, sell, have sold and import Products (defined below), on the terms and
subject to the conditions set forth herein.

        NOW, THEREFORE, in consideration of the mutual covenants and promises
hereinafter set forth, the Parties hereby agree as follows:

                                    ARTICLE 1
                                   DEFINITIONS

        1.1 "AFFILIATE" shall mean any corporation or other entity which
controls, is controlled by, or is under common control with, another corporation
or entity. A corporation or other entity shall be regarded as in control of
another corporation or entity if it owns or directly or indirectly controls more
than fifty percent (50%) of the voting securities or other ownership interest of
the other corporation or entity.

        1.1 "AUTOVAC(TM)" shall mean Pharmexa's therapeutic vaccine technology
for inducing a controlled therapeutic immune response against self-antigens that
cause or are associated with disease by introducing a modified antigen
consisting of a foreign epitope inserted into such a self-antigen.

        1.3 "AUTOVAC(TM) MOLECULE" shall mean any molecule created, identified
or developed using AutoVac(TM) directed to any Target Antigen.

        1.4 "CONFIDENTIAL INFORMATION" shall mean any confidential or
proprietary information of a Party or its Affiliate, including information
related to the Licensed Technology,

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and any other information relating to any compound, research project, work in
process, future development, scientific, engineering, manufacturing, marketing,
business plan, financial or personnel matter relating to such Party or its
Affiliate, its present or future products, sales, suppliers, customers,
employees, investors or business, whether in oral, written, graphic or
electronic form, including, without limitation, trade secrets, processes,
formulae, data and know-how, improvements, inventions, techniques, biological
materials, marketing plans, strategies, forecasts and customer and contact
lists.

        1.5 "CONTROL" shall mean possession of the ability to grant a license or
sublicense as provided for herein without violating the terms of any agreement
or other arrangement with any Third Party.

        1.6 "FIELD" shall mean the prevention and/or treatment of diseases or
disorders in humans.

        1.7 "FIRST COMMERCIAL SALE" shall mean the date of initial sale (or
other transfer) by Pharmexa and/or its Sublicensees to a Third Party of a
Product for compensation (or equivalent cash value for trades and any other such
non-cash payments). The sale (or other transfer) of a Product by Pharmexa or its
Sublicensees strictly for their laboratory research and development purposes,
beta-testing and/or clinical testing shall not constitute a First Commercial
Sale for the purposes of this Agreement, provided that Pharmexa or its
Sublicensees receives no payment for such Product in excess of the fully
burdened (i.e., direct and indirect) costs of producing and transporting such
materials.

        1.8 "KNOW-HOW" shall mean all inventions, discoveries, materials,
technology, trade secrets, data, processes, techniques, procedures,
compositions, devices, methods, formulas, protocols and information, or other
know-how, whether or not patentable, which are (i) Controlled by Epimmune as of
the Effective Date or during the Term, (ii) not generally publicly known and
(iii) pertain to PADRE(R).

        1.9 "LICENSED TECHNOLOGY" shall mean, to the extent necessary or useful
for research, development, manufacture, use, sale or import of Products in the
Field, all Patent Rights and Know-How, including all PADRE(R) Improvements
(defined in Section 5.1(b)).

        1.10 "NET SALES" shall mean the gross amounts invoiced for sales (or
other transfers) of Products by Pharmexa and/or its Sublicensees to Third
Parties, less deductions, charges and/or credits (which shall be itemized or
otherwise reasonably identified as follows: (i) reasonable trade, cash and
quantity discounts or rebates, if any, actually allowed or paid, (ii) credits or
allowances actually given or made for rejection or return of previously sold
products or for retroactive price reductions (including Medicaid, Medicare,
government, commercial and similar types of rebates), (iii) taxes, duties or
other governmental charges levied on or measured by the billing amount
(excluding income and franchise taxes), as adjusted for rebates and refunds and,
(iv) charges actually incurred for freight and insurance directly related to the
distribution of the Product in final form to Third Party customers (excluding
amounts reimbursed by Third Party customers), and (v) reasonable credits or
allowances actually given or made for wastage replacement (except where any such
wastage arises out of the negligence or willful misconduct

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<PAGE>   3

of Pharmexa and/or its Sublicensees). Other deductions, charges and/or credits
customary in the trade may be allowed upon mutual written agreement between the
Parties.

        1.11 "PADRE(R)" shall mean a peptide capable of binding antigen binding
sites on major histocompatibility complex (MHC) molecules encoded by
substantially all alleles of a DR locus, including, without limitation, a
composition comprising a peptide recited in the claims of United States Patent
Application Serial No. 08/121,101 filed September 14, 1993 and any patent
applications, U.S., international and foreign, that derive priority from such
patent application, such as continuing applications (including, without
limitation, any continuations, continuations-in-part or divisionals thereof) and
any patents issuing therefrom. Such peptides are also referred to as pan DR
binding peptides and include, without limitation, AKXVAAWTLKAAA (using the
single letter designation for amino acids), wherein X is cyclohexylalanine or
phenylalanine, and other peptides claimed and/or disclosed in the patent
applications described in this Section 1.11.

        1.12 "PATENT RIGHTS" shall mean all patents and patent applications,
including provisional applications, and all patents issuing thereon (including
utility, model and design patents and certificates of invention), together with
all reissue patents, patents of addition, divisions, renewals, continuations,
continuations-in-part, continued prosecution applications, requests for
continued examination, substitutions, additions, extensions or restorations (by
existing or future extension or restoration mechanisms, including, without
limitation, supplemental protection certificates), registrations, confirmations,
reexaminations and foreign counterparts of any of the foregoing, which are (i)
Controlled by Epimmune as of the Effective Date or during the Term, and (ii)
pertain to PADRE(R), including, without limitation, the patents and patent
applications listed on Appendix I.

        1.13 "PHASE I CLINICAL TRIALS" shall mean that portion of the clinical
development program with respect to a pharmaceutical product which generally
provides for the introduction into humans of the product with the primary
purpose of determining safety, metabolism and pharmacokinetic properties and
clinical pharmacology of the product.

        1.14 "PRODUCT" shall mean any product that contains, is comprised of or
uses PADRE(R) in combination or association with any AutoVac(TM) Molecule.

        1.15 "SUBLICENSEE" shall mean any Affiliate of Pharmexa or any Third
Party to which Pharmexa has granted a sublicense pursuant to Section 2.2.

        1.16   "TARGET ANTIGEN" shall mean any ***.

        1.17 "THIRD PARTY" shall mean any entity other than Epimmune or Pharmexa
or an Affiliate of Epimmune or Pharmexa.

*** Confidential Treatment Requested

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                                    ARTICLE 2
                                GRANT OF LICENSE

        2.1 GRANT. Subject to the terms and conditions of this Agreement,
Epimmune hereby grants to Pharmexa a non-exclusive, non-transferable (except in
accordance with Section 8.1), worldwide, royalty-bearing license, with the right
to grant sublicenses in accordance with Section 2.2, under the Licensed
Technology to make, have made, sell, have sold and import Products in the Field
during the Term. For avoidance of doubt, Pharmexa shall only have the right
under the license granted pursuant to this Section 2.1 to use PADRE(R) as part
of a Product.

        2.2 SUBLICENSING RIGHTS.

            (a) Pharmexa shall have the right to grant sublicenses under the
rights granted to it under Section 2.1 to its Affiliates or to any Third Party
to which Pharmexa licenses rights to one or more Products, subject to the terms
and conditions of this Agreement. Sublicensees may grant further sublicenses to
such rights in accordance with the terms of this Agreement. A copy of any such
sublicense shall be provided to Epimmune within fifteen (15) days of its
execution.

            (b) Any sublicense granted by Pharmexa, or any Sublicensee, under
this Agreement shall be subject and subordinate to, and consistent with, the
terms and conditions of this Agreement. Pharmexa shall notify any Sublicensee of
all rights and obligations of Pharmexa under this Agreement applicable to such
Sublicensee, including, without limitation, Section 3.9 and Article 4. In the
event of a material default by any Sublicensee under a sublicense agreement with
Pharmexa, Pharmexa will inform Epimmune and take such action which in Pharmexa's
reasonable business judgment will effectively address such default.

            (c) If this Agreement terminates for any reason, any Sublicensee
shall automatically become a direct licensee of Epimmune with respect to the
rights originally sublicensed to it by Pharmexa, provided such Sublicensee did
not cause the termination of this Agreement and such Sublicensee agrees to
comply with all of the terms of this Agreement and assume the responsibilities
of Pharmexa hereunder, including, without limitation, the making of payments and
reports directly to Epimmune and the remedying of any breach by Pharmexa of this
Agreement, to the extent reasonably practicable.

        2.3 DISCLOSURE OF LICENSED TECHNOLOGY. As of the Effective Date,
Epimmune shall have disclosed and transferred to Pharmexa all relevant
information relating to the Licensed Technology in existence as of the Effective
Date, and the practice thereof in accordance with the license granted under
Section 2.1. The parties acknowledge that Epimmune has transferred to Pharmexa
prior to the Effective Date certain information relevant to the Licensed
Technology in order for Pharmexa to carry out its due diligence under that
certain Confidentiality Agreement between Epimmune and Pharmexa dated May 4,
2001. Epimmune shall inform Pharmexa in writing of all Padre(R) Improvements
arising after the Effective Date.

        2.4 ***.

*** Confidential Treatment Requested

                                       4
<PAGE>   5

                                    ARTICLE 3
                               PAYMENT OBLIGATIONS

        3.1 LICENSE FEE. In partial consideration for the license granted
hereunder, Pharmexa agrees to pay to Epimmune a *** fee equal to *** to be paid
as follows:

            (a) *** shall be due and payable on the Effective Date; and

            (b) *** shall be due and payable within fifteen (15) days after the
Approval Date (as defined in Section 2.4).

        3.2 ROYALTIES. In partial consideration of the license granted
hereunder, Pharmexa agrees to pay to Epimmune the following royalties:

            (a) for Products directed to *** of Net Sales;

            (b) for Products directed to ***:

                (i) *** of Net Sales for Net Sales less than *** in any calendar
year during the Term;

                (ii) *** of Net Sales for Net Sales greater than or equal to ***
but less than *** in any calendar year during the Term; and

                (iii) *** of Net Sales for Net Sales greater than *** in any
calendar year during the Term.

        3.3 ROYALTY TERM. Pharmexa's obligations to pay royalties hereunder
shall commence upon First Commercial Sale in a given country and continue on a
Product-by-Product and country-by-country basis until, in each case, the later
to occur of (a) the expiration of the last-to-expire Patent Right covering the
manufacture, use or sale of such Product in the country in which it is sold, or
(b) the expiration of the period following the First Commercial Sale during
which Pharmexa is entitled to receive royalties from any Sublicensee based on
the sale (or other transfer) of any Product; provided, however, that if such
royalties are reduced during such period described in this subsection (b), then
the royalty rates to be paid by Pharmexa to Epimmune hereunder shall be reduced
in proportion to such reduction; provided further, however, that in no event
will the royalty rates to be paid by Pharmexa to Epimmune hereunder be reduced
by more than *** of the original royalty rates set forth herein.

        3.4 SUBLICENSING FEE. In the event Pharmexa is a party to an agreement
or arrangement with any Sublicensee (excluding any Affiliate of Pharmexa)
involving research, development, manufacture or commercialization of any Product
that includes the grant to such Sublicensee of a sublicense to any Product,
Pharmexa agrees to pay to Epimmune a fee representing ***.

*** Confidential Treatment Requested

                                       5
<PAGE>   6

        3.5 CURRENCY. All payments to Epimmune due hereunder shall be paid in
United States dollars. Royalty payments on sales of Products made in currencies
other than United States dollars will be calculated using the appropriate
foreign exchange rate for such currency quoted by the Chase Manhattan Bank New
York's foreign exchange desk on the last business day of the quarter preceding
the quarter in which payments are due to Epimmune.

        3.6 REPORTS; TIMING OF PAYMENTS. During the Term and for a period of two
(2) years thereafter, Pharmexa agrees to keep proper records and books of
account in accordance with generally accepted accounting practices, showing the
sales of Products by Pharmexa and its Sublicensees upon which the royalty
payments are based, the license fees and milestone payments received by Pharmexa
upon which the sublicensing fees are based, and all other information necessary
for the accurate determination of payments to be made to Epimmune hereunder.
Pharmexa agrees to deliver to Epimmune within *** following each *** during the
Term a report showing the information on which the payments herein provided are
calculated, along with any payment due thereby. All such reports made by
Pharmexa to Epimmune shall be treated as Confidential Information subject to
Article 4. Except for the license fee under Section 3.1, all payments of
royalties and fees due pursuant to this Agreement shall be made by Pharmexa to
Epimmune *** within *** after the end of each *** during the Term.

        3.7 LATE PAYMENT. In the event that payment of the license fee under
Section 3.1 or royalty payment under Section 3.2 is not made when due, the
payment shall accrue interest from the date due at the rate of ***; provided,
however, that in no event shall such rate exceed the maximum legal annual
interest rate. The payment of such interest shall not limit Epimmune from
exercising any other rights it may have as a consequence of the lateness of such
payment.

        3.8 WITHHOLDING TAXES. All amounts owing from Pharmexa to Epimmune under
this Agreement are gross amounts. Actual payments to Epimmune shall be net of
any withholding taxes, value-added taxes or other materially similar taxes,
levies or charges with respect to such amounts, other than United States taxes,
payable by Pharmexa or its sublicensees, or any taxes required to be withheld by
Pharmexa or its sublicensees having a permanent establishment in any country or
otherwise being subject to taxation by such country (except solely by reason of
the license granted hereunder); provided, however that Epimmune reserves the
right to contest such withholding. Pharmexa shall cooperate with Epimmune and
shall assist Epimmune, at Epimmune's expense, in contesting any such withholding
contested by Epimmune. Pharmexa shall promptly supply Epimmune with official
documentation regarding determination and payment of any such taxes and take
such other reasonable steps that may be necessary or appropriate to enable or
assist Epimmune in making an appropriate claim for any refund or relief from any
double taxation.

*** Confidential Treatment Requested

                                       6
<PAGE>   7

        3.9 AUDIT RIGHTS. During the Term and for period of two (2) years
thereafter, on thirty (30) days prior written notice, Epimmune shall have the
right to have an independent certified public accountant, inspect the books and
records of Pharmexa and its Affiliates, once per calendar year during usual
business hours for the sole purpose of and only to the extent necessary to
verify the completeness and accuracy of the records and payments made under this
Agreement. Such examination with respect to any calendar year shall not take
place later than two (2) years following the end of such calendar year. The
accountant shall inform Epimmune only if there has been an underpayment or an
overpayment, and if so, the amount thereof and whether the books and records
have been kept in a manner consistent with good accounting practices. To the
extent of any underpayment, Pharmexa shall promptly remit to Epimmune all
amounts due to Epimmune, together with interest in accordance with Section 3.8.
The expense of any such inspection shall be borne by Epimmune; provided,
however, that, if the inspection discloses an error in excess of *** in favor of
Pharmexa, then Pharmexa shall pay the full cost of such audit. In the event of
any overpayment by Pharmexa, the amount overpaid shall be credited against
future royalties owed to Epimmune by Pharmexa.

                                    ARTICLE 4
                                 CONFIDENTIALITY

        4.1 CONFIDENTIALITY. During the Term and for a period of five (5) years
thereafter, Epimmune will maintain in confidence all Confidential Information
disclosed by Pharmexa or its Affiliates hereunder, and Pharmexa will maintain
and will cause its Sublicensees to maintain in confidence all Confidential
Information disclosed by Epimmune or its Affiliates hereunder. Neither Party
will use, disclose or grant use of such Confidential Information except as
expressly authorized by this Agreement. To the extent that disclosure is
authorized by this Agreement, the disclosing Party will obtain prior agreement
from its employees, agents, consultants and Sublicensees to whom disclosure is
to be made to hold in confidence and not make use of such information for any
purpose other than those permitted by this Agreement. Each Party will use at
least the same standard of care as it uses to protect its own Confidential
Information to ensure that such employees, agents, consultants and Sublicensees
do not disclose or make any unauthorized use of such Confidential Information.
Each Party will promptly notify the other upon discovery of any unauthorized use
or disclosure of the Confidential Information.

        4.2 EXCEPTIONS. The obligations of confidentiality contained in Section
4.1 will not apply to the extent that it can be established by the receiving
Party by competent written proof that such Confidential Information:

            (a) is now, or hereafter becomes, through no act or failure to act
on the part of the receiving Party, generally known or available to the public;

            (b) is known by the receiving Party at the time of receiving such
information or is developed by receiving Party thereafter in the course of work
entirely independent of and without reference to any Confidential Information
disclosed by the disclosing Party, in each case, as evidenced by its records; or

*** Confidential Treatment Requested

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            (c) is hereafter furnished to the receiving Party by a Third Party,
as a matter of right and without restriction on disclosure, which Third Party is
not under an obligation of confidentiality to the disclosing Party.

        4.3 AUTHORIZED DISCLOSURE. Each Party may disclose the Confidential
Information of the other Party to the extent such disclosure (a) is the subject
of a written permission to disclose provided by such other Party, or (b) is
reasonably necessary in filing or prosecuting patent applications, prosecuting
or defending litigation or complying with applicable governmental regulations,
including, but not limited to the conduct by Pharmexa of any clinical trials or
registration of any Product, provided that if such Party is required to make any
such disclosure of such Confidential Information it will give reasonable advance
notice to the other Party of such disclosure requirement with an opportunity to
review and revise the proposed disclosure and, except to the extent
inappropriate in the case of patent applications, will use reasonable efforts to
secure confidential treatment of such information required to be disclosed.

        4.4 PRESS RELEASE. The Parties agree that a press release announcing the
matters covered by this Agreement in substantially the form attached hereto as
Appendix II will be issued, and either Party may publicize the existence and
general subject matter of this Agreement consistent with such press release
without the other Party's approval.

                                    ARTICLE 5
                          INTELLECTUAL PROPERTY RIGHTS

        5.1 OWNERSHIP OF INVENTIONS.

            (a) Inventorship of inventions shall be determined in accordance
with the rules of inventorship under United States patent law.

            (b) Epimmune shall have sole ownership of all inventions,
discoveries, developments and improvements made, conceived or reduced to
practice in the course of activities conducted under this Agreement pertaining
to PADRE(R) or its manufacture, use or sale, regardless of whether made solely
by employees and agents of Epimmune, solely by employees or agents of Pharmexa
or jointly by employees or agents of Epimmune and employees or agents of
Pharmexa ("PADRE(R) Improvements"), and all patent applications, patents and
other intellectual property rights directed to such PADRE(R) Improvements;
provided, however that PADRE(R) Improvements do not include any inventions,
discoveries, developments or improvements made, conceived or reduced to practice
in the course of activities conducted under this Agreement that pertain to
AutoVac(TM) or any AutoVac(TM) Molecule. Pharmexa hereby irrevocably assigns to
Epimmune all right, title and interest in and to any such PADRE(R) Improvements
and all patent applications, patents and all other intellectual property rights
directed to such PADRE(R) Improvements. In the event that Pharmexa is legally
unable to assign such rights to Epimmune, then Pharmexa agrees either to waive
the enforcement of such rights against Epimmune and any sublicensees and
assignees, or to grant Epimmune an exclusive, irrevocable, perpetual, worldwide,
fully-paid license, with right to sublicense through multiple tiers of
sublicense, to such rights.

                                       8
<PAGE>   9

            (c) Except as provided in Section 5.1(b), ownership of all
inventions, discoveries, developments and improvements conceived or reduced to
practice in the course of activities conducted under this Agreement, and all
patent applications, patents and other intellectual property rights directed to
such inventions, discoveries, developments and improvements, shall be determined
in accordance with inventorship (i.e., a Party shall solely own all such
inventions, discoveries, developments and improvements made solely by its
employees or agents, and the Parties shall jointly own all such inventions,
discoveries, developments and improvements made jointly by their respective
employees or agents).

        5.2 FILING, PROSECUTION AND MAINTENANCE OF PATENTS AND PATENT
APPLICATIONS. Epimmune shall have the sole right to control the filing,
prosecution and maintenance of, all patent applications and patents included in
the Patent Rights and the PADRE(R) Improvements, at Epimmune's expense. Epimmune
shall keep Pharmexa advised of the status of the actual and prospective patent
filings included in the Patent Rights, including, without limitation, the filing
of any patent application or grant of any patent. As between the Parties, the
Party that owns any patent applications and patents arising in the course of
activities conducted under this Agreement shall have the sole right, at its own
expense, to control, and the other Party shall fully cooperate with such Party
to facilitate, the filing, prosecution and maintenance of such patent
applications and patents. With respect to joint patent applications or patents
arising in the course of activities conducted under this Agreement, if any, the
Parties will share equally the control of and expenses associated with the
filing, prosecution and maintenance of such joint patent applications or
patents, unless a party disclaims ownership of any such joint patent application
or patent, in which case such party shall assign to the other party all its
right, title and interest in and to any such joint patent application or patent,
and such other party shall have the sole right to control, file, prosecute and
maintain any such joint patent application or patent, in its sole discretion and
at its sole expense.

        5.3 INFRINGEMENT ACTIONS.

            (a) Each Party agrees to notify the other promptly of any
infringement of any Patent Rights in the Field of which it is or becomes aware.

            (b) Epimmune shall have the sole right, at its discretion, to
prosecute any and all infringements of any Patent Rights, whether inside or
outside the Field.

            (c) Pharmexa shall have the first right, in its sole discretion to
control at its own expense the defense of all charges of infringement by any
Third Party arising as a result of the manufacture, use or sale of any Product
in the Field by Pharmexa or any of its Sublicensees. Epimmune shall have the
right to be represented by counsel of its own selection, at its own expense, and
shall cooperate fully in the defense of such suit and furnish to Pharmexa all
evidence and assistance in its control. If Pharmexa declines to bring such
action or proceeding, then Epimmune shall have the right, at its discretion, to
control at its own expense the defense of such charges of infringement, and
Pharmexa shall have the right, at its own expense, to be represented in any such
action by counsel of its own choice.

            (d) The party controlling the suit under Section 5.3(c) may not
settle the suit or otherwise consent to an adverse judgment in such suit, if
such settlement or judgment would

                                       9
<PAGE>   10

diminish the rights or interests of the non-controlling party, without the prior
written consent of the non-controlling party, which consent shall not be
unreasonably withheld or delayed.

                                    ARTICLE 6
                     REPRESENTATIONS; WARRANTIES; COVENANTS

        6.1 CORPORATE POWER. Each Party hereby represents and warrants that it
is duly organized, validly existing and in good standing under the laws of the
state or jurisdiction of its incorporation or formation and has full corporate
power and authority to enter into this Agreement and to carry out the provisions
hereof.

        6.2 DUE AUTHORIZATION. Each Party hereby represents and warrants that it
is duly authorized to execute and deliver this Agreement and to perform its
obligations hereunder.

        6.3 BINDING AGREEMENT. Each Party hereby represents and warrants that
this Agreement is a legal and valid obligation binding upon it and is
enforceable in accordance with its terms. The execution, delivery and
performance of this Agreement by such Party does not conflict with any
agreement, instrument or understanding, oral or written, to which it is a party
or by which it may be bound, nor violate any law or regulation of any court,
governmental body or administrative or other agency having authority over it.

        6.4 EXISTING RIGHTS. Epimmune represents and warrants that, as of the
Effective Date, the Patent Rights are existing and, to the best of its
knowledge, are not invalid or unenforceable, in whole or in part.

        6.5 RIGHT AND TITLE. Epimmune represents and warrants that, as of the
Effective Date, to the best of its knowledge, it owns the sole right, title and
interest in and to the Patent Rights.

        6.6 DISCLAIMER OF WARRANTIES. EXCEPT AS EXPRESSLY SET FORTH IN THIS
AGREEMENT, NEITHER PARTY MAKES ANY REPRESENTATION OR WARRANTY TO ANY OTHER PARTY
OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING, WITHOUT LIMITATION, ANY WARRANTY OF
TITLE, NON-INFRINGEMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE.

        6.7 GOVERNMENTAL APPROVALS; COMPLIANCE WITH APPLICABLE LAWS. Pharmexa
shall be responsible for obtaining all necessary governmental approvals for the
conduct of any research, development and commercialization of Products,
including the conduct of any clinical trials, at Pharmexa's expense. Pharmexa
shall conduct such activities in compliance with all applicable laws and
regulations.

        6.8 INDEMNIFICATION.

            (a) Pharmexa hereby agrees to save, defend, indemnify and hold
harmless Epimmune and its officers, directors, employees, consultants and agents
from and against any and all losses, damages, liabilities, expenses and costs,
including reasonable legal expense and attorneys' fees ("Losses"), to which any
of them may become subject as a result of any claim, demand, action or
proceeding by any Third Party to the extent such Losses arise directly or

                                       10
<PAGE>   11

indirectly out of (i) the manufacture, use or sale by Pharmexa or its
Sublicensees of Products, (ii) the conduct of any research and development,
including, without limitation, clinical trials, conducted with respect to the
Products, (iii) a breach by Pharmexa of any of its representations and
warranties contained in this Article 6, (iv) any breach by Pharmexa of any of
its obligations under this Agreement, (v) any Product, or (vi) the negligence or
willful misconduct of Pharmexa or its Affiliates or Sublicensees in performance
of this Agreement, except to the extent such Losses result from (a) the
negligence or willful misconduct of Epimmune, (b) are covered by Epimmune's
obligation to indemnify Pharmexa under Section 6.8(b)(i), or (c) a Third Party's
claim that the Licensed Technology infringes the patent rights of such Third
Party. In the event a party entitled to indemnification under this Section
6.8(a) seeks indemnification hereunder, it shall inform Pharmexa of a claim as
soon as reasonably practicable after it receives notice of the claim, shall
permit Pharmexa to assume direction and control of the defense of the claim
(including the right to settle the claim solely for monetary consideration), and
shall cooperate as requested (at the expense of Pharmexa) in the defense of the
claim.

            (b) Epimmune hereby agrees to save, defend, indemnify and hold
harmless Pharmexa and its respective officers, directors, employees, consultants
and agents from and against any and all Losses to which any of them may become
subject as a result of any claim, demand, action or proceeding by any Third
Party to the extent such Losses arise directly or indirectly out of (i) a breach
by Epimmune of any of its representations and warranties contained in this
Article 6, (ii) any breach by Epimmune of any of its obligations under this
Agreement, or (iii) the negligence or willful misconduct of Epimmune or its
Affiliates in performance of this Agreement, except to the extent such Losses
result from the negligence or willful misconduct of Pharmexa. In the event a
Party entitled to indemnification under this Section 6.8(b) seeks
indemnification hereunder, it shall inform Epimmune of a claim as soon as
reasonably practicable after it receives notice of the claim, shall permit
Epimmune to assume direction and control of the defense of the claim (including
the right to settle the claim solely for monetary consideration), and shall
cooperate as requested (at the expense of Epimmune) in the defense of the claim.

                                    ARTICLE 7
                                TERM; TERMINATION

        7.1 TERM. This Agreement shall commence as of the Effective Date and,
unless terminated earlier as provided herein, shall continue until the
expiration of the Royalty Term set forth in Section 3.7 (the "Term").

        7.2 TERMINATION FOR CAUSE. Either Party may terminate this Agreement
prior to the expiration of the Term: (i) if the other Party commits a breach of
any of its obligations under this Agreement, which breach is not cured within
*** after such Party provides such other Party with written notice thereof, such
notice referring to the relevant provisions of this Agreement and identifying
the activities alleged to be resulting in such breach, or (ii) immediately upon
written notice if (x) the other Party becomes insolvent or makes an assignment
for the benefit of

*** Confidential Treatment Requested

                                       11
<PAGE>   12

creditors, or (y) bankruptcy proceedings are instituted against such other Party
or on such other Party's behalf. In addition, in the event bankruptcy
proceedings are instituted against Epimmune or on Epimmune's behalf, then the
Parties hereby acknowledge and agree that Pharmexa will have the right to make,
have made, sell, have sold and import Products consistent with the terms of this
Agreement for purposes of 11 U.S.C. Section 365(n).

        7.3 EFFECT OF TERMINATION. Upon termination of this Agreement, all
rights under the Licensed Technology shall revert to Epimmune. Pharmexa and its
Sublicensees shall have the right to sell their inventory of Products then on
hand, subject to the obligations to pay Epimmune royalties on Net Sales of such
Products pursuant to Section 3.2. Within thirty (30) days following the
expiration or termination of this Agreement, each Party shall return to the
other Party, or destroy, upon the written request of the other Party, any and
all Confidential Information of the other Party in its possession. Expiration or
termination of this Agreement shall not relieve the Parties of any obligation
accruing prior to such expiration or termination. The provisions of Sections
3.6, 3.9, 6.6, 6.8 and 7.3 and Articles 1, 4, 5, and 8 shall survive termination
or expiration of this Agreement.

                                    ARTICLE 8
                                  MISCELLANEOUS

        8.1 ASSIGNMENT. Except as expressly provided hereunder, neither this
Agreement nor any rights or obligations hereunder may be assigned or otherwise
transferred by either Party without the prior written consent of the other Party
(which consent shall not be unreasonably withheld); provided, however, that
either Party may assign this Agreement and its rights and obligations hereunder
without the other Party's consent (a) in connection with the transfer or sale of
all or substantially all of the business of such Party to which this Agreement
relates to a Third Party, whether by merger, sale of stock, sale of assets or
otherwise, or (b) to any Affiliate. Notwithstanding the foregoing, any such
assignment to an Affiliate shall not relieve the assigning Party of its
responsibilities for performance of its obligations under this Agreement. The
rights and obligations of the parties under this Agreement shall be binding upon
and inure to the benefit of the successors and permitted assigns of the parties.
Any assignment not in accordance with this Agreement shall be void.

        8.2 FORCE MAJEURE. No Party shall be held liable or responsible to any
other Party nor be deemed to have defaulted under or breached this Agreement for
failure or delay in fulfilling or performing any term of this Agreement (other
than non-payment) when such failure or delay is caused by or results from causes
beyond the reasonable control of the affected Party, including, without
limitation, fire, floods, earthquakes, natural disasters, embargoes, war, acts
of war (whether war be declared or not), insurrections, riots, civil commotions,
strikes, power outages, lockouts or other labor disturbances, acts of God or
acts, omissions or delays in acting by any governmental authority or any other
Party to this Agreement.

        8.3 GOVERNING LAW. This Agreement shall be governed by, and construed
and enforced solely and exclusively in accordance with, the laws of the State of
California, U.S.A., without regard to its choice of law provisions.

                                       12
<PAGE>   13

        8.4 LIMITATION OF LIABILITY EXCEPT FOR AMOUNTS PAYABLE UNDER ARTICLE 3
AND LIABILITY FOR BREACH OF ARTICLE 2 OR 4, EACH PARTY SHALL BE LIABLE TO THE
OTHER ONLY FOR ACTUAL DAMAGES AND NOT FOR ANY SPECIAL, PUNITIVE, CONSEQUENTIAL,
INCIDENTAL OR INDIRECT DAMAGES ARISING OUT OF THIS AGREEMENT, HOWEVER CAUSED,
UNDER ANY THEORY OF LIABILITY.

        8.5 WAIVER. Except as specifically provided for herein, the waiver from
time to time by a Party of any right or failure to exercise any remedy shall not
operate or be construed as a continuing waiver of the same right or remedy or of
any other of such Party's rights or remedies provided under this Agreement.

        8.6 SEVERABILITY. In case any provision of this Agreement shall be
invalid, illegal or unenforceable, the validity, legality and enforceability of
the remaining provisions shall not in any way be affected or impaired thereby.

        8.7 INDEPENDENT CONTRACTORS. It is expressly agreed that Epimmune and
Pharmexa shall be independent contractors and that the relationship among them
shall not constitute a partnership, joint venture or agency of any kind. No
Party shall have the authority to make any statements, representations or
commitments of any kind, or to take any action, which shall be binding on any
other Party, without the prior written consent of such other Party.

        8.8 NOTICES. All notices and other communications provided for hereunder
shall be in writing and shall be mailed by first-class, registered or certified
mail, postage paid, or delivered personally, by overnight delivery service or by
facsimile, with confirmation of receipt, addressed as follows:

        IF TO EPIMMUNE:             EPIMMUNE INC.
                                    5820 Nancy Ridge Drive
                                    San Diego, CA  92121
                                    United States
                                    Attention:  President
                                    Facsimile:  (858) 860-2600

        IF TO PHARMEXA:             PHARMEXA A/S
                                    Kogle Alle 6
                                    Horsholm
                                    2970
                                    Denmark
                                    Attention:  President
                                    Facsimile:  +45 45 16 2500

        Any Party may by like notice specify or change an address to which
notices and communications shall thereafter be sent. Notices sent by facsimile
shall be effective upon confirmation of receipt, notices sent by mail or
overnight delivery service shall be effective upon receipt, and notices given
personally shall be effective when delivered.

                                       13
<PAGE>   14

        8.9 ENTIRE AGREEMENT; AMENDMENT. This Agreement (including the Exhibits
attached hereto) sets forth all of the agreements and understandings between the
Parties with respect to the subject matter hereof, and supersedes and terminates
all prior and contemporaneous agreements and understandings between the Parties
with respect to the subject matter hereof. There are no agreements or
understandings with respect to the subject matter hereof, either oral or
written, between the Parties other than as set forth herein. Except as expressly
set forth in this Agreement, no subsequent amendment, modification or addition
to this Agreement shall be binding upon the Parties hereto unless reduced to
writing and signed by the respective authorized officers of Epimmune and
Pharmexa.

        8.10 HEADINGS. The captions contained in this Agreement are not a part
of this Agreement, but are merely guides or labels to assist in locating and
reading the several Articles hereof.

        8.11 COUNTERPARTS. This Agreement may be executed in two or more
counterparts, by facsimile, or both, each of which shall be deemed an original,
but all of which together shall constitute one and the same instrument.

              [THE REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK]

                                       14
<PAGE>   15

        IN WITNESS WHEREOF, the Parties have executed this Agreement as of the
date first set forth above.

EPIMMUNE INC.                               PHARMEXA A/S

By:     /s/ Robert De Vaere                  By:    /s/ Birger Borregaard
   ----------------------------                 --------------------------------

Name:   Robert De Vaere                      Name:  Birger Borregaard
     --------------------------                   ------------------------------

Title:  VP, Finance & CFO                    Title: COO
      -------------------------                    -----------------------------

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