Document:

Exhibit 4.3

    

    

    THIS GLOBAL SECURITY IS HELD BY AND REGISTERED IN THE NAME OF THE DEPOSITARY (AS DEFINED IN THE INDENTURE GOVERNING THIS SECURITY) OR ITS
        NOMINEE IN CUSTODY FOR THE BENEFIT OF THE BENEFICIAL OWNERS HEREOF, IS NOT EXCHANGEABLE FOR SECURITIES REGISTERED IN THE NAME OF A PERSON OTHER THAN THE DEPOSITARY OR ITS NOMINEE EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE, AND
        IS NOT TRANSFERABLE TO ANY PERSON UNDER ANY CIRCUMSTANCES EXCEPT THAT (I) THE TRUSTEE MAY MAKE SUCH NOTATIONS HEREON AS MAY BE REQUIRED PURSUANT TO SECTION 11.04 OF THE INDENTURE, (II) THIS GLOBAL SECURITY MAY BE EXCHANGED PURSUANT TO SECTION
        2.01(c) OF THE INDENTURE, (III) THIS GLOBAL SECURITY MAY BE DELIVERED TO THE TRUSTEE FOR CANCELATION PURSUANT TO SECTION 2.08 OF THE INDENTURE AND (IV) THIS GLOBAL SECURITY MAY BE TRANSFERRED TO A SUCCESSOR DEPOSITARY WITH THE PRIOR WRITTEN CONSENT
        OF THE COMPANY.

    

    

    UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION (“DTC”), NEW
        YORK, NEW YORK, TO THE COMPANY OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND
        ANY PAYMENT IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER
        HEREOF, CEDE & CO., HAS AN INTEREST HEREIN.

    

    

    BRUNSWICK CORPORATION

    6.625% Senior Notes due 2049

    

    

    	
            REGISTERED

          	
            CUSIP No. 117043 505

          
	
            No. R-1

          	
            ISIN No. US1170435051

          

    

    

    

    

    Brunswick Corporation, a corporation duly organized and existing under the laws of the State of Delaware (herein called the “Company,”
        which term includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede & Co., or registered assigns, the principal amount set forth on the Schedule of Exchanges of Interests in
        Global Securities attached hereto, which principal amount may from time to time be reduced or increased, as appropriate, in accordance with the within mentioned Indenture and as reflected in the Schedule of Exchanges of Interests in the Global
        Security attached hereto, to reflect exchanges or redemptions of the Securities represented hereby, on January 15, 2049, and to pay interest thereon from December 3, 2018 or from the most recent Interest Payment Date to which interest has been paid
        or duly provided for, quarterly in arrears on January 15, April 15, July 15 and October 15 in each year, commencing on January 15, 2019, at the rate of 6.625% per annum, until the principal hereof is paid or made available for payment; provided, however that any principal and premium, and any such installment of interest, which is
        overdue shall bear interest at the rate of 6.625% per annum (to the extent that the payment of such interest shall be legally enforceable), from the dates such amounts are due until they are paid or made available for payment.  The interest so
        payable, and punctually paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture, be paid to the Person in whose name this Security is registered at the close of business on the Regular Record Date for such
        interest, which shall be the January 1, April 1, July 1 and October 1 (whether or not a Business Day), as the case may be, next preceding such Interest Payment Date.  Any such interest not so punctually paid or duly provided for will forthwith
        cease to be payable to the Holder on such Regular Record Date and shall be paid to the Person in whose name this Security is registered at the close of business on a date to be fixed by the Company for the payment of such Defaulted Interest (a
        “Special Record Date”), notice whereof shall be given to Holder of Securities of this series not less than 15 days prior to such Special Record Date.

    

    

    
      
        

    

    Payment of the principal of (and premium, if any) and any such interest on this Security will be made at the office or agency of the
        Company maintained for that purpose in accordance with the terms of the Indenture referred to on the reverse hereof in United States dollars.

    

    

    Reference is hereby made to the further provisions of this Security set forth on the reverse hereof, which further provisions shall for all
        purposes have the same effect as if set forth at this place.

    

    

    This Security shall be governed by, and construed in accordance with, the laws of the State of New York.

    

    

    Unless the certificate of authentication hereon has been executed by the Trustee referred to on the reverse hereof by manual signature,
        this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose.

    

    

    
      
        

    

    IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed.

    

    

    	
            Dated:

          	 	
            BRUNSWICK CORPORATION

          
	 	 
	 	
            By:

          	 
	 	 	
            Name:

          
	 	 	
            Title:

          

    

    

    
      
        

    

    CERTIFICATE OF AUTHENTICATION

    

    

    This is one of the Securities of the series designated therein referred to in the within-mentioned Indenture.

    

    

    	
            Dated:

          	 	
            U.S. BANK NATIONAL ASSOCIATION, AS TRUSTEE

          
	 	 
	 	
            By:

          	 
	 	 	
            Authorized Signatory

          

    

    

    
      
        

    

    [REVERSE OF NOTE]

    

    

    This Security is one of a duly authorized issue of securities of the Company (herein called the “Securities”), issued and to be issued in
        one or more series under an Indenture (herein called the “Base Indenture,” which term shall have the meaning assigned to it in such instrument), dated as of October 3, 2018, between the Company and U.S. Bank National Association, as Trustee (herein
        called the “Trustee,” which term includes any successor trustee under the Indenture), as supplemented by the Second Supplemental Indenture (herein called the “Second Supplemental Indenture,” which term shall have the meaning assigned to it in such
        instrument, and together with the Base Indenture, herein called the “Indenture”), dated as of December 3, 2018, between the Company and the Trustee, and reference is hereby made to the Indenture for a statement of the respective rights, limitations
        of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be, authenticated and delivered.  This Security is one of the series designated on
        the face hereof, initially limited in aggregate principal amount to $132,250,000.

    

    

    The Securities of this series shall be redeemable at the Company’s option in accordance with the terms and conditions specified in Section
        2.06 of the Second Supplemental Indenture and Article Three of the Base Indenture.

    

    

    If a Change of Control Triggering Event occurs, unless the Company has exercised its option to redeem the Securities, each holder of the
        Securities will have the right to require the Company to purchase all or a portion of such holder’s Securities as set forth in Section 2.10 of the Second Supplemental Indenture.

    

    

    The Indenture contains provisions for defeasance at any time of the entire indebtedness of this Security or certain covenants and Events of
        Default with respect to this Security, in each case upon compliance with certain conditions set forth in the Indenture.

    

    

    If an Event of Default with respect to Securities of this series shall occur and be continuing, the principal of the Securities of this
        series may be declared due and payable in the manner and with the effect provided in the Indenture.

    

    

    The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the modification of the rights and
        obligations of the Company and the rights of the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and the Trustee with the consent of the Holders of a majority in aggregate principal amount of
        the Securities at the time Outstanding of each series to be affected.  The Indenture also contains provisions permitting the Holders of specified percentages in aggregate principal amount of the Securities of each series at the time Outstanding, on
        behalf of the Holders of all Securities of such series, to waive compliance by the Company with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences.  Any such consent or waiver by the Holder of
        this Security shall be conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange hereof or in lieu hereof, whether or not notation of such
        consent or waiver is made upon this Security.

    

    

    
      
        

    

    

    

    No reference herein to the Indenture and no provision of this Security or of the Indenture shall alter or impair the obligation of the
        Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Security at the times, place and rate, and in the coin or currency, herein prescribed.

    

    

    As provided in the Indenture and subject to certain limitations therein set forth, the transfer of this Security may be registered and this
        Security may be exchanged as provided in the Indenture.

    

    

    The Securities of this series are issuable only in registered form without coupons in denominations of $25.00 and any integral multiples of
        $25.00 in excess thereof.

    

    

    No service charge shall be made for any such registration of transfer or exchange, but the Company may require payment of a sum sufficient
        to cover any tax or other governmental charge payable in connection therewith.

    

    

    Prior to due presentment of this Security for registration of transfer, the Company, the Trustee and any agent of the Company or the
        Trustee may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the
        contrary.

    

    

    No recourse for the payment of the principal of or premium, if any, or interest on any Security, or for any claim based thereon or
        otherwise in respect thereof, and no recourse under or upon any obligation, covenant or agreement of the Company, contained in the Indenture or in any
        supplemental indenture, or in any Security, or because of the creation of any Indebtedness represented thereby, shall be had against any incorporator, stockholder, officer or director, past, present or future, of the Company or any successor
        Persons, either directly or through the Company or any such successor Person, whether by virtue of any constitution, statute or rule of law, or by the enforcement of any assessment or penalty or otherwise. Each Holder by accepting a Security waives
        and releases all such liabilities.  The waiver and release are part of the consideration for issuance of the Securities.

    

    

    All terms used in this Security which are defined in the Indenture shall have the meanings assigned to them in the Indenture.

    

    

    
      
        

    

    ASSIGNMENT FORM

    

    

    	
            To assign this Security, fill in the form below:

          
	 	 
	
            I or we assign and transfer this Security to:

          
	 	 
	 
	
            (Insert assignee's social security or tax I.D. no.)

          
	 	 
	 	 
	 
	 
	 
	
            (Print or type assignee's name, address and zip code)

          
	 	 
	
            and irrevocably appoint as agent to transfer this Security on the books of the Company.  The agent may substitute another to act for him.

          
	 	 
	 
	 	 
	
            Your

          	 
	
            Signature:

          	
            (Sign exactly as your name appears on the other side of this Security)

          
	 	 
	
            Your

          	 
	
            Name:

          	 
	 	 
	
            Date:

          	 
	 	 
	 	 
	
            Signature

          	
            *

          
	
            Guarantee:

          	 
	 	 
	
            *

          	
            NOTICE:  The Signature must be guaranteed by an Institution which is a member of one of the following recognized signature Guarantee Programs:  (i)
                The Securities Transfer Agent Medallion Program (STAMP); (ii) The New York Stock Exchange Medallion Program (MNSP); (iii) The Stock Exchange Medallion Program (SEMP); or (iv) such other guarantee program acceptable to the Trustee

          

    

    

    
      
        

    

    OPTION OF HOLDER TO ELECT PURCHASE

    

    

    If you want to elect to have this Security purchased by the Company pursuant to Section 2.10 of the Second Supplemental Indenture, check the box:

    

    

    ☐ 

    

    

    If you want to elect to have only part of this Security purchased by the Company pursuant to Section 2.10 of the Second Supplemental Indenture, state the
        amount in principal amount (must be in denominations of $25.00 or any integral multiples of $25.00 in excess thereof):

     

      

  

  
    	
             

              

            $:

          	 	 	 	 
	 	 	 	 
	
            Date:

          	 	
            Your Signature:  

              

          	 
	 	 

          	(Sign exactly as your name appears on the other side of the Security)
	 	 
	
            Signature Guarantee:

          	 	 
	 	
            (Signature must be guaranteed)

          	 
	
            *

          	
            NOTICE:  The Signature must be guaranteed by an Institution which is a member of one of the following recognized signature Guarantee Programs:  (i)
                The Securities Transfer Agent Medallion Program (STAMP); (ii) The New York Stock Exchange Medallion Program (MNSP); (iii) The Stock Exchange Medallion Program (SEMP); or (iv) such other guarantee program acceptable to the Trustee

          

    

    

    
      
        

    

    SCHEDULE OF EXCHANGES OF INTERESTS IN THE GLOBAL SECURITY

    

    

    The initial Outstanding principal amount of this Global Security is $115,000,000.

    

    

    The following exchanges of an interest in this Global Security for an interest in another Global Security or for a Definitive Security, exchanges of an
        interest in another Global Security or a Definitive Security for an interest in this Global Security, or exchanges or purchases of a part of this Global Security have been made:

    

    

    	
            
              Date of Exchange

            

          	
            
              Amount

                  of

                  decrease

                  in

                  Principal

                  Amount

                  of this

                  Global

                  Security

            

          	
            
              Amount

                  of

                  increase

                  in

                  Principal

                  Amount

                  of this

                  Global

                  Security

            

          	
            
              Principal

                  Amount

                  of this

                  Global

                  Security

                  following

                  such

                  decrease

                  or

                  increase

            

          	
            
              Signature

                  of

                  authorized

                  signatory of

                  Trustee or

                  Securities

                  CustodianExhibit 10.2

 

 

AMENDMENT TO EMPLOYMENT AGREEMENT

 

THIS
AMENDMENT TO EMPLOYMENT AGREEMENT (this “Amendment”) is made on this 27th day of November, 2018
(the “Effective Date”), by and between Marker Therapeutics, Inc., a Delaware corporation (the “Company”),
and Michael J. Loiacono, an individual (the “Executive”), and amends that certain Employment Agreement between
the Company and the Executive, dated August 25, 2016 (the
 “Employment Agreement”).

 

RECITALS:

 

WHEREAS, the
Company and the Executive entered into the Employment Agreement on August 25, 2016; and

 

WHEREAS, the
Company desires to appoint a new Chief Financial Officer, however, the Company desires to retain Executive to continue to serve
as the Company’s Chief Accounting Officer; and

 

WHEREAS, the
Company and the Executive wish to amend the Executive’s Employment Agreement, to provide for Executive’s services as
Chief Accounting Officer and thereby the relinquishment of the office of Chief Financial Officer as provided herein.

 

NOW THEREFORE,
the Executive and the Company for themselves, their heirs, successors and assigns, in consideration of their mutual promises contained
herein, intending to be legally bound, hereby agree that the Employment Agreement is hereby amended as follows:

 

1.       Section
1 and 2 of the Employment Agreement are hereby deleted and replaced in their entirety with the following:

 

2.       EMPLOYMENT. The
Company will employ the Executive as the Chief Accounting Officer of the Company, and the Executive agrees to serve in such capacities
and provide his services to the Company on the terms and conditions set forth in this Agreement.

 

3.       POSITION
AND DUTIES. On and after the date of this Agreement, the Executive will serve as the Chief Accounting Officer of the Company.
The Executive agrees that during the Term (as defined below) he shall dedicate his full business time, attention and energies to
performing his duties to the Company, as prescribed by the Chief Executive Office (the “CEO”) and Chief Financial
Officer (the “CFO”). The Executive will manage the accounting affairs of the Company and perform the duties
typically assigned to the Chief Accounting Officer of a similarly situated company in the Company’s industry. The Executive
shall also perform such other reasonable duties as may hereafter be assigned to him by the CEO or CFO, consistent with his abilities
and position as the Chief Accounting Officer and providing such further services to the Company as may reasonably be requested
of him. The Executive will report to the CEO of the Company, and carry out the financial decisions and otherwise abide by
and enforce the lawful rules and policies of the Company.

 

     

     

    

 

The Executive shall
devote his best business efforts to the business and affairs of the Company and, during the Term, shall observe at all times the
covenants regarding non-competition, and confidentiality provided in Sections 5, 6 and 7 below. The Company and Executive
acknowledge and agree that, during the Term, Executive shall be permitted to (i) serve on corporate, civic or charitable boards
or committees, and (ii) manage passive personal investments, so long as any such activities do not unduly interfere with the
performance of Executive’s responsibilities as an employee of the Company in accordance with this Agreement.

 

2.       Section
4(a)-(b) of the Employment Agreement are hereby deleted and replaced in their entirety with the following:

 

4. COMPENSATION AND BENEFITS.

 

(a) Base Salary. At
the Effective Date, the Executive’s annual base salary shall be two hundred seventy five thousand dollars ($275,000) per
year, which shall be paid bi-weekly by the Company to the Executive in accordance with the Company’s customary payroll practices,
subject to customary withholding as required by applicable law. This annual base salary shall be reviewed by the CEO periodically,
and the CEO may increase the Executive’s annual base salary from time to time as the CEO deems to be appropriate subject
to performance and market conditions. The Executive’s salary will not be reduced without Executive’s prior written
consent except that the Board may, in its sole discretion, reduce Executive’s base salary in connection with a salary reduction
applicable to all Company senior executive officers in substantially the same proportions.

 

(b) Annual Incentive
Compensation. During the Term, the Executive shall be eligible for an annual performance bonus of up to thirty-five percent
(35%) of the Executive’s annual base salary, based on goals and other conditions as the Board (or duly authorized committee
thereof), shall determine in its sole discretion on an annual basis (the “Annual Performance Bonus”). The Annual
Performance Bonus will be payable in the form of cash or fully-vested shares of the Company’s common stock, or a combination
thereof, at the Board’s (or duly authorized committee thereof), discretion, in any case to be paid or delivered as soon as
practicable after the end of the year in which it is earned and in any event not more than ninety (90) days after the end of such
year. Payment of the Annual Performance Bonus shall be expressly conditioned upon Executive’s employment with the Company
on the date that the Annual Performance Bonus is paid, except as provided in Section 9(b) and Section 10(a) below

 

Any such Annual Performance
Bonus, as well as any equity awards which are granted to the Executive or which become vested as a result of the satisfaction of
financial performance goals of the Company, shall be subject to the Company’s Policy on Recoupment of Executive Incentive
Compensation, and that the Executive shall be obligated to repay to the Company, any and all amounts received with respect to the
Annual Performance Bonus or performance-based equity awards, to the extent such a repayment is required by the terms of the Policy
on Recoupment of Executive Incentive Compensation, as such policy may be amended from time to time.

 

    2 

     

    

 

3.       Section
9 of the Employment Agreement is hereby amended to read as follows in its entirety:

 

9.       SEVERANCE
PAY.

 

(a)       In
the event the Executive’s employment with the Company is terminated by the Company during the Term for Cause (as defined
in Section 8(d) above), or by the Executive other than for Good Reason (as defined in Section 8(e) above), the compensation
and benefits the Executive shall be entitled to receive from the Company shall be limited to:

 

(i)       his
then-current annual base salary pursuant to Section 4 through the date of termination, payable in accordance with the Company’s
standard payroll practices;

 

(ii)       any
reimbursable expenses for which the Executive has not yet been reimbursed as of the date of termination; and

 

(iii)       any
other rights and vested benefits (if any) provided under employee benefit plans and programs of the Company, determined in accordance
with the applicable terms and provisions of such plans and programs.

 

Any annual performance
bonus under Section 4(b) earned for a prior year but not yet paid by the Company shall be forfeited if the Executive’s
employment with the Company is terminated by the Company for Cause or is terminated by the Executive for other than Good Reason.
If the Executive’s employment with the Company is terminated during the Term due to death or Disability, in addition to the
amounts in Subsection (a) of this Section 9, the Executive shall also be entitled to receive any annual performance
bonus that, as of the date of termination, has been earned by the Executive but has not yet been paid by the Company to the Executive
with such payments being made in the form determined by the Board as provided in Section 4(b).

 

(b)       If
the Executive’s employment with the Company is terminated during the Term, either by the Company without Cause or by the
Executive for Good Reason, in addition to the amounts in Subsection (a) of this Section 9, the Executive shall also
be entitled to receive severance pay equal to twelve (12) months of his annual base salary pursuant to Section 4, at the
rate in effect on the date of termination. This severance pay shall be paid to the Executive in cash in a single lump sum payment,
within sixty (60) days after the date of the termination of the Executive’s employment with the Company, but no earlier than
fifteen (15) days after the Executive’s execution and non-revocation of a general release of all claims against the Company,
its officers, directors, employees and affiliates, in form and substance satisfactory to the Company (the “Release”).
In addition, the Executive shall also receive upon termination any annual performance bonus that, as of the date of termination,
has been earned by the Executive but has not yet been paid by the Company to the Executive for the calendar year prior to the calendar
year in which termination occurs. For the calendar year in which termination occurs, Executive shall receive an Annual Performance
Bonus payable at the highest performance amount for the pro rata portion of the calendar year Executive served the Company, provided
that, the Executive has served a minimum of six months during the calendar year of any termination under this subsection. Any applicable
performance bonus is to be paid in such form as provided in Section 4(b). In addition, the Company shall pay the cost for
Executive to continue his health insurance benefits under COBRA for a period of twelve (12) months after termination of employment,
or the Company will fund an alternative health care insurance plan for the same dollar amount as would be payable under COBRA for
such period.

 

    3 

     

    

 

		(c)	If the Company exercises its right to provide Executive with a termination notice pursuant to Section
3, in addition to the amounts in Subsection (a) of this Section 9, at termination, Executive shall also be entitled to receive
severance pay equal to twelve months of his annual base salary at the rate in effect at termination payable in twelve equal monthly
payments.

 

(d)       Notwithstanding
anything in this Agreement to the contrary, it will be a condition to the Executive’s right to receive any severance benefits
under Subsections (b) and (c) of this Section 9 that he execute and deliver the Release to the Company upon his separation
from service, and that he does not revoke the Release during the fifteen (15) day period thereafter. Subject to Section 14
below, the severance payments under this Section 9 will be made no earlier than fifteen (15) days after the Executive has
executed, delivered and not revoked the Release as required under this Section 9.

 

4.       Except
as expressly amended by this Amendment, the Employment Agreement shall continue and remain in full force and effect.

 

 

 

[SIGNATURE PAGE TO FOLLOW]

 

 

 

    4 

     

    

 

IN WITNESS WHEREOF,
the Parties have executed this Agreement as of the date first written above, to be effective on the Effective Date, for the purposes
herein contained.

 

	COMPANY –Marker Therapeutics, Inc.	 	EXECUTIVE	 
	 	 	 	 	 
	 	 	 	 	 
	By:	/s/Peter L. Hoang	 	/s/Michael J. Loiacono	 
	Name: 	Peter L. Hoang	 	Name: Michael J. Loiacono	 
	Title: 	Chief Executive Officer	 	 	 

 

 

 

 

 

 

 

 

[Signature Page to Amendment to Employment
Agreement]

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