Document:

Exhibit
10.15

NEITHER THIS SECURITY NOR
THE SECURITIES INTO WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED
WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY
STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT
OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE
OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER
THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM, OR IN A
TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT
AND IN ACCORDANCE WITH APPLICABLE STATE SECURITIES LAWS AS EVIDENCED BY A LEGAL
OPINION OF COUNSEL TO THE TRANSFEROR TO SUCH EFFECT, THE SUBSTANCE OF WHICH
SHALL BE REASONABLY ACCEPTABLE TO THE COMPANY.

AMENDED AND
RESTATED COMMON STOCK PURCHASE WARRANT

To Purchase 166,667 Shares of Common Stock of  Clarient, Inc.

THIS COMMON STOCK
PURCHASE WARRANT CERTIFIES that, for value received, Safeguard Delaware, Inc.
(the “Holder”), is entitled, upon the terms and subject to the limitations on
exercise and the conditions hereinafter set forth, on or prior to the close of
business on January 17, 2011 (the “Termination Date”) but not thereafter, to
subscribe for and purchase from Clarient, Inc., a corporation incorporated in
the State of Delaware (the “Company”), up to 166,667 shares (the “Warrant
Shares”) of Common Stock, par value $0.01 per share, of the Company (the “Common
Stock”).  The purchase price of one share
of Common Stock (the “Exercise Price”) under this Warrant shall be $1.64, and
the Exercise Price and the number of Warrant Shares for which the Warrant is
exercisable shall be subject to adjustment as provided herein.

1.             Amendment
and Restatement of Warrant.  This
Warrant amends and restates in its entirety the Common Stock Purchase Warrant
issued to Holder on January 17, 2011 to purchase up to 250,000 shares of Common
Stock (the “Prior Warrant”) to reflect the agreement between the Company and
the Holder that 166,667 shares of Common Stock underlying the Prior Warrant
have become Vested Shares (as defined in the Prior Warrant) under the Prior
Warrant and that no additional shares of Common Stock underlying the Prior
Warrant shall become Vested Shares.  Accordingly,
this Warrant supersedes and replaces in its entirety the Prior Warrant which
shall be cancelled on the books of the Company.

2.             Title
to Warrant.  Prior to the Termination
Date and subject to compliance with applicable laws and Section 8 of this
Warrant, this Warrant and all rights hereunder are transferable, in whole or in
part, at the office or agency of the Company by the Holder in person or by duly
authorized attorney and upon surrender of this Warrant together with the
Assignment Form annexed hereto properly endorsed.  The transferee shall sign an investment
letter in form and substance reasonably satisfactory to the Company.

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3.             Authorization of
Shares.  The Company covenants that
all Warrant Shares which may be issued upon the exercise of the purchase rights
represented by this Warrant will, upon exercise of the purchase rights
represented by this Warrant, be duly authorized, validly issued, fully paid and
nonassessable and free from all taxes, liens and charges in respect of the
issue thereof (other than taxes in respect of any transfer occurring
contemporaneously with such issue).

4.             Exercise of
Warrant.

(a)  Exercise
of the purchase rights represented by this Warrant may be made at any time on
or before the Termination Date by delivering the Notice of Exercise Form
annexed hereto duly completed and executed (which delivery may be by
facsimile), at the office of the Company (or such other office or agency of the
Company as it may designate by notice in writing to the registered Holder at
the address of such Holder appearing on the books of the Company) and upon full
payment of the Exercise Price of the shares thereby purchased by wire transfer
or cashier’s check drawn on a United States bank or by means of a cashless
exercise pursuant to Section 4(d), the Holder shall be entitled to receive a
certificate for the number of Warrant Shares so purchased.  Certificates for shares purchased hereunder
shall be delivered to the address specified by the Holder in the Notice of
Exercise within three (3) business days from the delivery to the Company of the
Notice of Exercise Form, surrender of this Warrant and payment of the aggregate
Exercise Price as set forth above (“Warrant Share Delivery Date”).  In lieu of delivering physical certificates
for the shares purchased hereunder, provided the Company’s transfer agent is
participating in the Depository Trust Company (“DTC”) Fast Automated
Securities Transfer program, and so long as the resale of the shares underlying
this Warrant is covered by an effective registration statement or the legend upon
the certificates for the shares may be removed in accordance with applicable
securities laws, upon request of the Holder, the Company shall use commercially
reasonable efforts to cause its transfer agent electronically to transmit such
shares by crediting the account of the Holder’s prime broker with DTC through
its Deposit Withdrawal Agent Commission system (provided that the same time
limitations herein as for stock certificates shall apply and that the Company
may in all events satisfy its obligations to deliver certificates by delivery
of physical stock certificates).  This
Warrant shall be deemed to have been exercised on the date the Exercise Price
is received by the Company.  The Warrant
Shares shall be deemed to have been issued, and Holder or any other person so
designated to be named therein shall be deemed to have become a holder of
record of such shares for all purposes, as of the date the Warrant has been
exercised by payment to the Company of the Exercise Price.

(b)  In
addition to any other rights available to the holder, if the Company fails to
deliver or cause its transfer agent to deliver or transmit (in the manner
contemplated by clause (a) above) to the Holder a certificate or certificates
representing the Shares pursuant to an exercise on or before the Warrant Share
Delivery Date, and if after such date the holder is required by its broker to
purchase (in an open market transaction or otherwise) shares of Common Stock to
deliver in 

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satisfaction of a sale by the holder of the
Shares which the Holder anticipated receiving upon such exercise (a “Buy-In”),
then the Company shall promptly honor its obligation to deliver to the Holder
such Warrant Shares and pay in cash to the holder the amount by which (x) the
holder’s total purchase price (including brokerage commissions, if any) for the
shares of Common Stock so purchased exceeds (y) the amount obtained by
multiplying (A) the number of Shares that the Company was required to deliver
to the holder in connection with the exercise at issue times (B) the closing
price per share on date of exercise. The holder shall provide the Company
written notice indicating the amounts payable to the Holder in respect of the
Buy-In, together with applicable confirmations and other evidence reasonably
requested by the Company.  Nothing herein
shall limit a Holder’s right to pursue any other remedies available to it
hereunder, at law or in equity including, without limitation, a decree of
specific performance and/or injunctive relief with respect to the Company’s
failure to timely deliver certificates representing shares of Common Stock upon
exercise of the Warrant as required pursuant to the terms hereof.

(c)  Notwithstanding
anything to the contrary set forth herein, upon partial exercise of this
Warrant in accordance with the terms hereof, the Holder shall not be required
to physically surrender this Warrant to the Company unless such Holder is
purchasing the full amount of Warrant Shares then represented by this
Warrant.  The Holder and the Company
shall maintain records showing the number of Warrant Shares so purchased
hereunder and the dates of such purchases or shall use such other method,
reasonably satisfactory to the Holder and the Company, so as not to require
physical surrender of this Warrant upon each such exercise.  The requirement of physical surrender upon
full exercise shall be satisfied by the Holder mailing, postage prepaid, or
arranging for delivery by commercial courier this Warrant to the Company’s
notice address.

(d)  This
Warrant may also be exercised at such time by means of a “cashless exercise” in
which the Holder shall be entitled to receive a certificate for the number of
Warrant Shares equal to the quotient obtained by dividing ((A-B) (X)) by (A),
where:

(A) =  the last reported sale price of the Common
Stock on the business day immediately preceding the date of such election or,
if not reported, the fair market value of such Common Stock as reasonably
determined by the Company’s Board of Directors;

(B) =  the
Exercise Price, as adjusted; and

(X) =  the
number of Warrant Shares with respect to which this Warrant is being exercised.

5.             No Fractional
Shares or Scrip.  No fractional
shares or scrip representing fractional shares shall be issued upon the
exercise of this Warrant.  As to any fraction
of a share which Holder would otherwise be entitled to purchase upon such
exercise, the Company shall pay a cash adjustment in respect of such final
fraction in an amount equal to such fraction multiplied by the Exercise Price.

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6.             Charges, Taxes and
Expenses.  Issuance of certificates
for Warrant Shares shall be made without charge to the Holder for any issue or
transfer tax or other incidental expense in respect of the issuance of such
certificate, all of which taxes and expenses shall be paid by the Company, and
such certificates shall be issued in the name of the Holder or in such name or
names as may be directed by the Holder; provided, however, that in the event
certificates for Warrant Shares are to be issued in a name other than the name
of the Holder, this Warrant when surrendered for exercise shall be accompanied
by the Assignment Form attached hereto duly executed by the Holder; and the
Company may require, as a condition thereto, the payment of a sum sufficient to
reimburse it for any transfer tax incidental thereto, compliance with the
provisions of Section 8 and an investment letter from the transferee in form
and substance reasonably satisfactory to the Company.

7.             Closing of Books.  The Company will not close its stockholder
books or records in any manner which prevents the timely exercise of this
Warrant, pursuant to the terms hereof.

8.             Transfer, Division
and Combination.

(a)  Subject
to compliance with any applicable securities laws and the conditions set forth
in Sections 2 and 8 hereof, this Warrant and all rights hereunder are
transferable, in whole or in part, upon surrender of this Warrant at the
principal office of the Company, together with a written assignment of this
Warrant, substantially in the form attached hereto duly executed by the Holder
or its agent or attorney and funds sufficient to pay any transfer taxes payable
upon the making of such transfer.  Upon
such surrender and, if required, such payment, the Company shall execute and deliver
a new Warrant or Warrants in the name of the assignee or assignees and in the
denomination or denominations specified in such instrument of assignment, and
shall issue to the assignor a new Warrant evidencing the portion of this
Warrant not so assigned, and this Warrant shall promptly be cancelled.  A Warrant, if properly assigned, may be
exercised by a new holder for the purchase of Warrant Shares without having a
new Warrant issued.

(b)  This
Warrant may be divided or combined with other Warrants upon presentation hereof
at the aforesaid office of the Company, together with a written notice
specifying the names and denominations in which new Warrants are to be issued,
signed by the Holder or its agent or attorney. 
Subject to compliance with Section 8(a), as to any transfer which may be
involved in such division or combination, the Company shall execute and deliver
a new Warrant or Warrants in exchange for the Warrant or Warrants to be divided
or combined in accordance with such notice.

(c)  The
Company shall prepare, issue and deliver at its own expense (other than
transfer taxes) the new Warrant or Warrants under this Section 8.

(d)  The
Company agrees to maintain, at its aforesaid office, books for the registration
and the registration of transfer of the Warrants.   This Warrant 

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may not be transferred or sold except
pursuant to an effective registration statement under the Securities Act of
pursuant to an available exemption from, or in a transaction not subject to,
the registration requirements of the Securities Act and in accordance with
applicable state securities laws.  If, at
the time of the surrender of this Warrant in connection with any transfer of
this Warrant, the transfer of this Warrant shall not be registered pursuant to
an effective registration statement under the Securities Act of 1933, as
amended (the “Securities Act”) and under applicable state securities or blue
sky laws, the Company may require, as a condition of allowing such transfer (i)
that the Holder or transferee of this Warrant, as the case may be, furnish to the
Company a written opinion of counsel (which opinion shall be in form, substance
and scope customary for opinions of counsel in comparable transactions) to the
effect that such transfer may be made without registration under the Securities
Act and under applicable state securities or blue sky laws, (ii) that the
holder or transferee execute and deliver to the Company an investment letter in
form and substance reasonably acceptable to the Company and (iii) that the
transferee be an “accredited investor” as defined in Rule 501(a) promulgated
under the Securities Act.

(e)                 Any securities
issued upon exercise of this Warrant shall bear the following legend:

THESE SECURITIES HAVE NOT BEEN REGISTERED WITH THE SECURITIES AND
EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON
AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED
(THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD
EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT
OR PURSUANT TO AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO,
THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE WITH
APPLICABLE STATE SECURITIES LAWS AS EVIDENCED BY A LEGAL OPINION OF COUNSEL TO
THE TRANSFEROR TO SUCH EFFECT, THE SUBSTANCE OF WHICH SHALL BE REASONABLY
ACCEPTABLE TO THE COMPANY.  SUBJECT TO
COMPLIANCE WITH APPLICABLE SECURITIES LAWS, THESE SECURITIES MAY BE PLEDGED IN
CONNECTION WITH A BONA FIDE MARGIN ACCOUNT WITH A REGISTERED BROKER-DEALER OR
OTHER LOAN WITH A FINANCIAL INSTITUTION THAT IS AN “ACCREDITED INVESTOR” AS
DEFINED IN RULE 501(a) UNDER THE SECURITIES ACT.

9.             No Rights as
Shareholder until Exercise.  This
Warrant does not entitle the Holder to any voting rights or other rights as a shareholder
of the Company prior to the exercise hereof. 
Upon the surrender of this Warrant and the payment of the aggregate
Exercise Price (or by means of a cashless exercise), the Warrant Shares so
purchased 

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shall be and be deemed to be issued to such Holder as
the record owner of such shares as of the close of business on the later of the
date of such surrender or payment.

10.           Loss, Theft,
Destruction or Mutilation of Warrant. 
The Company covenants that upon receipt by the Company of evidence
reasonably satisfactory to it of the loss, theft, destruction or mutilation of
this Warrant or any stock certificate relating to the Warrant Shares, and in
case of loss, theft or destruction, of indemnity or security reasonably
satisfactory to it (which, in the case of the Warrant, shall not include the
posting of any bond), and upon surrender and cancellation of such Warrant or
stock certificate, if mutilated, the Company will make and deliver a new
Warrant or stock certificate of like tenor and dated as of such cancellation,
in lieu of such Warrant or stock certificate.

11.           Saturdays, Sundays,
Holidays, etc.  If the last or
appointed day for the taking of any action or the expiration of any right
required or granted herein shall be a Saturday, Sunday or a legal holiday, then
such action may be taken or such right may be exercised on the next succeeding
day not a Saturday, Sunday or legal holiday.

12.           Adjustments of
Exercise Price and Number of Warrant Shares.  The number and kind of securities purchasable
upon the exercise of this Warrant and the Exercise Price shall be subject to
adjustment from time to time upon the happening of any of the following.  In case the Company shall (i) pay a dividend
in shares of Common Stock or make a distribution in shares of Common Stock to
holders of its outstanding Common Stock, (ii) subdivide its outstanding shares
of Common Stock into a greater number of shares, (iii) combine its outstanding
shares of Common Stock into a smaller number of shares of Common Stock, or (iv)
issue any shares of its capital stock in a reclassification of the Common
Stock, then the number of Warrant Shares purchasable upon exercise of this
Warrant immediately prior thereto shall be adjusted so that the Holder shall be
entitled to receive the kind and number of Warrant Shares or other securities
of the Company which it would have owned or have been entitled to receive had
such Warrant been exercised immediately prior to the occurrence of such
event.  Upon each such adjustment of the
kind and number of Warrant Shares or other securities of the Company which are
purchasable hereunder, the Holder shall thereafter be entitled to purchase the
number of Warrant Shares or other securities resulting from such adjustment at
an Exercise Price per Warrant Share or other security obtained by multiplying
the Exercise Price in effect immediately prior to such adjustment by the number
of Warrant Shares purchasable pursuant hereto immediately prior to such
adjustment and dividing such amount by the number of Warrant Shares or other
securities of the Company purchasable pursuant hereto as a result of such
adjustment (such that the aggregate purchase price for all Warrant Shares or
other securities resulting from such adjustment upon full exercise of this
Warrant shall remain the same).  An
adjustment made pursuant to this paragraph shall become effective immediately
after the effective date of such event.

13.           Reorganization,
Reclassification, Merger, Consolidation or Disposition of Assets.  In case the Company shall reorganize its
capital, reclassify its capital stock, consolidate or merge with or into
another corporation (where the Company is not the 

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surviving corporation or where there is a change in or
distribution with respect to the Common Stock of the Company), or sell,
transfer or otherwise dispose of all or substantially all its property, assets
or business to another corporation and, pursuant to the terms of such
reorganization, reclassification, merger, consolidation or disposition of
assets, shares of common stock of the successor or acquiring corporation, or
any cash, shares of stock or other securities or property of any nature
whatsoever (including warrants or other subscription or purchase rights) in
addition to or in lieu of common stock of the successor or acquiring
corporation (“Other Property”), are to be received by or distributed to the
holders of Common Stock of the Company, then the Holder shall have the right
thereafter to receive upon exercise of this Warrant (and this Warrant shall
thereafter be exercisable only for), the number of shares of Common Stock of
the successor or acquiring corporation or of the Company, if it is the
surviving corporation, and Other Property receivable upon or as a result of
such reorganization, reclassification, merger, consolidation or disposition of
assets by a Holder of the number of shares of Common Stock for which this
Warrant is exercisable immediately prior to such event. In case of any such
reorganization, reclassification, merger, consolidation or disposition of assets,
the successor or acquiring corporation (if other than the Company) shall
expressly assume the due and punctual observance and performance of each and
every covenant and condition of this Warrant to be performed and observed by
the Company and all the obligations and liabilities hereunder, subject to such
modifications as may be deemed appropriate (as determined in good faith by
resolution of the Board of Directors of the Company) in order to provide for
adjustments of Warrant Shares for which this Warrant is exercisable which shall
be as nearly equivalent as practicable to the adjustments provided for in this
Section 13.  For purposes of this Section
13, “common stock of the successor or acquiring corporation” shall include
stock of such corporation of any class which is not preferred as to dividends
or assets over any other class of stock of such corporation and which is not
subject to redemption.  The foregoing
provisions of this Section 13 shall similarly apply to successive
reorganizations, reclassifications, mergers, consolidations or disposition of
assets.

14.           Notice
of Adjustment.  Whenever the number
of Warrant Shares or number or kind of securities or other property purchasable
upon the exercise of this Warrant or the Exercise Price is adjusted, as herein
provided, the Company shall give notice thereof to the Holder, which notice
shall state the number of Warrant Shares (and other securities or property)
purchasable upon the exercise of this Warrant and the Exercise Price of such
Warrant Shares (and other securities or property) after such adjustment,
setting forth a brief statement of the facts requiring such adjustment and
setting forth the computation by which such adjustment was made.

15.           Notice of Corporate
Action.  If at any time:

(a)  the
Company shall take a record of the holders of its Common Stock for the purpose
of entitling them to receive a dividend or other distribution, or any right to
subscribe for or purchase any evidences of its indebtedness, any shares of
stock of any class or any other securities or property, or to receive any other
right, or

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(b)  there
shall be any capital reorganization of the Company, any reclassification or
recapitalization of the capital stock of the Company or any consolidation or
merger of the Company with, or any sale, transfer or other disposition of all
or substantially all the property, assets or business of the Company to,
another corporation that would trigger an adjustment pursuant to Section 13, or

(c)  there
shall be a voluntary or involuntary dissolution, liquidation or winding up of
the Company;

then, in any
one or more of such cases, the Company shall give to Holder (i) at least 20
days’ prior written notice of the date on which a record date shall be selected
for such dividend, distribution or right or for determining rights to vote in
respect of any such reorganization, reclassification, merger, consolidation,
sale, transfer, disposition, liquidation or winding up, and (ii) in the case of
any such reorganization, reclassification, merger, consolidation, sale,
transfer, disposition, dissolution, liquidation or winding up, at least 20 days’
prior written notice of the date when the same shall take place.  Such notice in accordance with the foregoing
clause also shall specify (i) the date on which any such record is to be taken
for the purpose of such dividend, distribution or right, the date on which the
holders of Common Stock shall be entitled to any such dividend, distribution or
right, and the amount and character thereof, and (ii) the estimated date on
which any such reorganization, reclassification, merger, consolidation, sale,
transfer, disposition, dissolution, liquidation or winding up is to take place
and the time, if any such time is to be fixed, as of which the holders of
Common Stock shall be entitled to exchange their Warrant Shares for securities
or other property deliverable upon such disposition, dissolution, liquidation
or winding up. Each such written notice shall be sufficiently given if
addressed to Holder at the last address of Holder appearing on the books of the
Company and delivered in accordance with Section 17(d).

16.           Authorized
Shares.  The Company covenants that
during the period the Warrant is outstanding, it will reserve from its
authorized and unissued Common Stock a sufficient number of shares to provide
for the issuance of the Warrant Shares upon the exercise of any purchase rights
under this Warrant. The Company further covenants that its issuance of this
Warrant shall constitute full authority to its officers who are charged with
the duty of executing stock certificates to execute and issue the necessary
certificates for the Warrant Shares upon the exercise of the purchase rights
under this Warrant.  The Company will
take all such reasonable action as may be necessary to assure that such Warrant
Shares may be issued as provided herein without violation of any applicable law
or regulation, or of any requirements of the Principal Market upon which the
Common Stock may be listed.

Except and to the extent
as waived or consented to by the Holder, the Company shall not by any action,
including, without limitation, amending its certificate of incorporation or
through any reorganization, transfer of assets, consolidation, merger,
dissolution, issue or sale of securities or any other voluntary action, avoid
or seek to avoid the observance or performance of any of the terms of this
Warrant, but will at all times in good faith assist in the carrying out of all
such terms and in the taking of all such actions as may be necessary or appropriate
to protect the rights of Holder as set forth in this Warrant against
impairment.  Without limiting the
generality of the foregoing, the Company will (a) not increase the par value of
any Warrant Shares above the amount payable therefor upon such exercise
immediately prior to such increase in par value, 

 8
 

(b) take all such action as may be necessary or appropriate in order
that the Company may validly and legally issue fully paid and nonassessable
Warrant Shares upon the exercise of this Warrant, and (c) use commercially
reasonable efforts to obtain all such authorizations, exemptions or consents
from any public regulatory body having jurisdiction thereof as may be necessary
to enable the Company to perform its obligations under this Warrant.

Before taking any action
which would result in an adjustment in the number of Warrant Shares for which
this Warrant is exercisable or in the Exercise Price, the Company shall obtain
all such authorizations or exemptions thereof, or consents thereto, as may be necessary
from any public regulatory body or bodies having jurisdiction thereof.

17.           Miscellaneous.

(a)  Jurisdiction.  This Warrant shall constitute a contract
under the laws of the State of New York.

(b)  Restrictions.  The Holder acknowledges that the Warrant
Shares acquired upon the exercise of this Warrant, if not registered, will have
restrictions upon resale imposed by state and federal securities laws.

(c)  Nonwaiver
and Expenses.  No course of dealing or
any delay or failure to exercise any right hereunder on the part of Holder
shall operate as a waiver of such right or otherwise prejudice Holder’s rights,
powers or remedies, notwithstanding all rights hereunder terminate on the
Termination Date.

(d)  Notices.  Any and all notices or other communications
or deliveries required or permitted to be provided hereunder shall be in
writing and shall be deemed given and effective on the earliest of (a) the date
of transmission, if such notice or communication is delivered via facsimile at
the facsimile number set forth on the signature pages attached hereto prior to
6:30 p.m. (New York City time) on a business day or by email to the email
address set forth on the signature pages attached hereto if such email is sent
prior to 6:30 p.m. (New York City time) on a business day, (b) the next
business day after the date of transmission or email, if such notice or
communication is delivered via facsimile at the facsimile number set forth on
the signature pages attached hereto or by email to the email address set forth on
the signature pages attached hereto on a day that is not a business day or
later than 6:30 p.m. (New York City time) on any business day, (c) the second
business day following the date of mailing, if sent by U.S. nationally
recognized overnight courier service, or (d) upon actual receipt by the party
to whom such notice is required to be given. 
The address for such notices and communications shall be as set forth on
the signature pages attached hereto.  Any
notice, request or other document required or permitted to be given or
delivered to the Holder by the Company shall be delivered in accordance with
this Section 17(d); provided upon any permitted assignment of this Warrant, the
assignee shall promptly provide the Company with its contact information.

(e)  Limitation
of Liability.  No provision hereof, in
the absence of 

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any affirmative action by Holder to exercise
this Warrant or purchase Warrant Shares, and no enumeration herein of the
rights or privileges of Holder, shall give rise to any liability of Holder for
the purchase price of any Common Stock or as a stockholder of the Company,
whether such liability is asserted by the Company or by creditors of the
Company.

(f)  Remedies.  Holder, in addition to being entitled to
exercise all rights granted by law, including recovery of damages, will be
entitled to specific performance of its rights under this Warrant.  The Company agrees that monetary damages
would not be adequate compensation for any loss incurred by reason of a breach
by it of the provisions of this Warrant and hereby agrees to waive the defense
in any action for specific performance that a remedy at law would be adequate.

(g)  Successors
and Assigns.  Subject to applicable
securities laws, this Warrant and the rights and obligations evidenced hereby
shall inure to the benefit of and be binding upon the successors of the Company
and the successors and permitted assigns of Holder.  The provisions of this Warrant are intended
to be for the benefit of all Holders from time to time of this Warrant and
shall be enforceable by any such Holder or holder of Warrant Shares.

(h)  Amendment
and Waiver.  This Warrant may be modified
or amended or the provisions hereof waived with the written consent of the
Company and the Holder.

(i)  Severability.  Wherever possible, each provision of this
Warrant shall be interpreted in such manner as to be effective and valid under
applicable law, but if any provision of this Warrant shall be prohibited by or
invalid under applicable law, such provision shall be ineffective to the extent
of such prohibition or invalidity, without invalidating the remainder of such
provisions or the remaining provisions of this Warrant.

(j)  Headings.  The headings used in this Warrant are for the
convenience of reference only and shall not, for any purpose, be deemed a part
of this Warrant.

********************

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IN WITNESS
WHEREOF, the Company has caused this Warrant to be executed by its officer
thereunto duly authorized.

Dated:  April
18, 2007

	
  

  	
  CLARIENT, INC.

  
	
   

  	
   

  
	
   

  	
  By:

  	
  /s/ James Agnello

  	
   

  
	
   

  	
  Name:  James
  Agnello

  
	
   

  	
  Title:  Senior
  Vice President and Chief Financial

  
	
   

  	
  Officer

  
	
   

  	
   

  
	
   

  	
  Notice Address:

  
	
   

  	
  31 Columbia

  
	
   

  	
  Aliso Viejo, CA 92656

  
	
   

  	
  Facsimile: 949-425-5863

  
	
   

  	
  Email: randrews@clarientinc.com

  

 

ACCEPTED AND AGREED

SAFEGUARD DELAWARE, INC.

	
  By:

  	
   /s/ Steven J.
  Feder

  	
   

  
	
  Name: Steven J. Feder

  	
   

  
	
  Title: Vice President

  	
   

  

 

Notice Address:

800 The Safeguard Building

435 Devon Park Drive

Wayne, PA 19087

Facsimile: 610-482-9105

Email:

NOTICE OF EXERCISE

To:          Clarient,
Inc.

(1) The
undersigned hereby elects to purchase                Warrant
Shares of Clarient, Inc. pursuant to the terms of the attached Warrant (only if
exercised in full), and tenders herewith payment of the exercise price in full,
together with all applicable transfer taxes, if any.

(2) Payment shall take
the form of (check applicable box):

[  ]   in lawful money of the United
States; or

[  ]   the cancellation of such number
of Warrant Shares as is necessary, in accordance with the formula set forth in
subsection 4(d), to exercise this Warrant with respect to the maximum number of
Warrant Shares purchasable pursuant to the cashless exercise procedure set
forth in subsection 4(d).

(3) Please issue a
certificate or certificates representing said Warrant Shares in the name of the
undersigned or in such other name as is specified below:

The Warrant Shares shall be delivered to the
following:

 

	
  

  	
   

  
	
   

  	
   

  
	
   

  	
   

  

(4) Accredited Investor.
The undersigned is an “accredited investor” as defined in Regulation D
promulgated under the Securities Act of 1933, as amended.

	
   

  	
  By:

  	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  Name:

  	
   

  	
   

  
	
   

  	
  Title:

  	
   

  	
   

  
	
   

  	
  Dated:

  	
   

  	
   

  
					

ASSIGNMENT FORM

 

(To assign the foregoing
warrant, execute this form and supply required information.  Do not use this form to exercise the
warrant.)

FOR VALUE
RECEIVED, the foregoing Warrant and all rights evidenced thereby are hereby
assigned to

                                                                              whose
address is                                                                               

Dated:                               ,
          

	
  Holder’s Signature:

  	
   

  	
  By:

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
  Holder’s Address:

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
  Signature Guaranteed:

  	
   

  	
   

  	
   

  

 

NOTE: The signature to
this Assignment Form must correspond with the name as it appears on the face of
the Warrant, without alteration or enlargement or any change whatsoever, and
must be guaranteed by a bank or trust company. Officers of corporations and
those acting in a fiduciary or other representative capacity should file proper
evidence of authority to assign the foregoing Warrant.Exhibit 10.16

NINTH AMENDMENT 

TO

LOAN AGREEMENT

This Ninth Amendment to Loan Agreement is entered into
as of March 15, 2007 (the “Amendment”) by and between COMERICA BANK (“Bank”)
and CLARIENT, INC. (“Borrower”).

RECITALS

Borrower and Bank are parties to that certain Loan
Agreement dated as of February 13, 2003, as amended, including, without
limitation, by that certain First Amendment to Loan Agreement dated as of
October 21, 2003, that certain Second Amendment to Loan Agreement dated as of
January 22, 2004, that certain Third Amendment to Loan Agreement dated as of
January 31, 2005, that certain Fourth Amendment to Loan Agreement dated as of
March 11, 2005, that certain Consent and Waiver dated as of July 13, 2005, that
certain letter agreement dated as of January 26, 2006, that certain Waiver and
Fifth Amendment to Loan Agreement dated as of August 1, 2006, that certain
Sixth Amendment to Loan Agreement dated as of February 28, 2006, that certain
Seventh Amendment to Loan Agreement dated as of January 17, 2007, and that
certain Waiver and Eighth Amendment to Loan Agreement dated as of February 28,
2007 (collectively, the “Agreement”). 
The parties desire to further amend the Agreement in accordance with the
terms of this Amendment.

NOW, THEREFORE, the parties agree as follows:

1.             Section 6.8 of the Agreement is amended to read as
follows;

6.8  Net Worth. 
Borrower shall maintain, at all times during the following periods, a
minimum Net Worth, as follows:

	
  Period

  	
   

  	
  Minimum Net Worth

  	
   

  
	
  March 15-June 29, 2007

  	
   

  	
  $

  	
  2,400,000

  	
   

  
	
  June 30-September 29,
  2007

  	
   

  	
  $

  	
  600,000

  	
   

  
	
  September 30-December
  30, 2007

  	
   

  	
  ($500,000

  	
  )

  
	
  December 31, 2007 and thereafter

  	
   

  	
  ($1,100,000

  	
  )

  

 

2.             The following definition is added to Section 1.1, as
follows:

“Net Worth” means with
respect to Borrower as of any date of determination, the sum of capital stock
and additional paid-in capital plus retained earnings (or minus accumulated
deficit) of Borrower and its Subsidiaries, minus intangible assets, on a
consolidated basis determined in accordance with GAAP.

3.             Unless otherwise defined, all initially capitalized
terms in this Amendment shall have the respective meanings set forth in the
Agreement.  The Agreement, as amended
hereby, shall be and remain in full force and effect in accordance with its
terms and hereby is ratified and confirmed in all respects.  Except as expressly set forth herein, the
execution, delivery, and performance of this Amendment shall not operate as a
waiver of, or as an amendment of, any right, power, or remedy of Bank under the
Agreement, as in effect prior to the date hereof.  Borrower ratifies and reaffirms the
continuing effectiveness of all instruments, documents and agreements entered
into in connection with the Agreement.

4.             This Amendment may be executed in two or more
counterparts, each of which shall be deemed an original, but all of which
together shall constitute one instrument.

5.             As a condition to the effectiveness of this Amendment,
Bank shall have received, in form and substance satisfactory to Bank, the
following:

 1
 

(a)           this Amendment, duly
executed by Borrower;

(b)           an officer’s
certificate of Borrower with respect to incumbency and resolutions authorizing
the execution and delivery of this Amendment;

(c)           an Affirmation of
Guaranty, duly executed by Safeguard Delaware, Inc. and Safeguard Scientifics
(Delaware), Inc.;

(d)           an amount equal to
all Bank Expenses incurred through the date of this Amendment; and

(e)           such other
documents, and completion of such other matters, as Bank may reasonably deem
necessary or appropriate.

[REMAINDER OF PAGE
INTENTIONALLY LEFT BLANK.]

 2
 

IN WITNESS
WHEREOF, the undersigned have executed this Amendment as of the first date
above written.

	
  

  	
  CLARIENT, INC.

  
	
   

  	
   

  	
   

  
	
   

  	
  By:

  	
  /s/ James Agnello

  
	
   

  	
   

  	
   

  
	
   

  	
  Title:

  	
  Senior Vice President and Chief Financial Officer

  
	
   

  	
   

  	
   

  
	
   

  	
  COMERICA BANK

  
	
   

  	
   

  	
   

  
	
   

  	
  By:

  	
  /s/ Beth Kinsey

  
	
   

  	
   

  	
   

  
	
   

  	
  Title:

  	
  Senior Vice President

  
					

 

 3
 

Corporation Resolutions and
Incumbency Certification

Authority to Procure Loans

I certify that I am the duly elected and qualified Secretary of
CLARIENT, INC. a Delaware corporation; that the following is a true and correct
copy of resolutions duly adopted by the Board of Directors of the Corporation
in accordance with its bylaws and applicable statutes.

Copy of
Resolutions:

Be it Resolved,
That:

1.               Any one (1) of the
following officers of the Corporation are/is authorized, for, on behalf of, and
in the name of the Corporation to:

(a)          Execute, deliver and
perform that certain Ninth Amendment to Loan Agreement dated as of March 15,
2007, as the same modifies that certain Loan Agreement dated as of February 13,
2003, as amended from time to time.

and

(b)         Execute and deliver in
form and content as may be required by the Bank any and all notes, evidences of
Indebtedness, applications for letters of credit, guaranties, subordination
agreements, loan and security agreements, financing statements, assignments,
liens, deeds of trust, mortgages, trust receipts and other agreements,
instruments or documents to carry out the purposes of these Resolutions, any or
all of which may relate to all or to substantially all of the Corporation’s
property and assets.

2.               Said Bank be and it
is authorized and directed to pay the proceeds of any such loans or discounts
as directed by the persons so authorized to sign, whether so payable to the
order of any of said persons in their individual capacities or not, and whether
such proceeds are deposited to the individual credit of any of said persons or
not;

3.               Any and all agreements,
instruments and documents previously executed and acts and things previously
done to carry out the purposes of these Resolutions are ratified, confirmed and
approved as the act or acts of the Corporation.

4.               These Resolutions
shall continue in force, and the Bank may consider the holders of said offices
and their signatures to be and continue to be as set forth in a certified copy
of these Resolutions delivered to the Bank, until notice to the contrary in
writing is duly served on the Bank (such notice to have no effect on any action
previously taken by the Bank in reliance on these Resolutions).

5.               Any person,
corporation or other legal entity dealing with the Bank may rely upon a
certificate signed by an officer of the Bank to effect that these Resolutions
and any agreement, instrument or document executed pursuant to them are still
in full force and effect and binding upon the Corporation.

6.               The Bank may
consider the holders of the offices of the Corporation and their signatures,
respectively, to be and continue to be as set forth in the Certificate of the
Secretary of the Corporation until notice to the contrary in writing is duly
served on the Bank.

I further certify that the above Resolutions are in
full force and effect as of the date of this Certificate; that these
Resolutions and any borrowings or financial accommodations under these
Resolutions have been properly noted in the corporate books and records, and
have not been rescinded, annulled, revoked or modified; that neither the
foregoing Resolutions nor any actions to be taken pursuant to them are or will
be in contravention of any provision of the articles of incorporation or bylaws
of the Corporation or of any agreement, indenture or other instrument to which
the Corporation is a party or by which it is bound; and that neither the
articles of incorporation nor bylaws of the Corporation nor any agreement,
indenture or other instrument to which the Corporation is a party or by which
it is bound require the vote or consent of shareholders of the Corporation to
authorize any act, matter or thing described in the foregoing Resolutions.

I further certify
that the following named persons have been duly elected to the offices set
opposite their respective names, that they continue to hold these offices at
the present time, and that the signatures which appear below are the genuine,
original signatures of each respectively:

 4
 

(PLEASE
SUPPLY GENUINE SIGNATURES OF AUTHORIZED SIGNERS BELOW)

	
  NAME (Type or Print)

  	
   

  	
  TITLE

  	
   

  	
  SIGNATURE

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  

In Witness Whereof, I have affixed my name as
Secretary and have caused the corporate seal (where available) of said
Corporation to be affixed on March 15, 2007.

	
  

  	
   

  	
   

  
	
   

  	
   

  	
  Secretary

  
	
   

  	
   

  	
   

  
	
  The Above
  Statements are Correct.

  	
   

  	
   

  
	
   

  	
   

  	
  signature of officer or
  director or, if none. a shareholder other than secretary when secretary is
  authorized to sign alone.

  
				

 

Failure to complete the
above when the Secretary is authorized to sign alone shall constitute a
certification by the Secretary that the Secretary is the sole Shareholder,
Director and Officer of the Corporation.

 

 5

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