Document:

Letter, dated August 22, 2005, to John D. Ratliff

 Exhibit 10.45 
 August 22, 2005 
 John Ratliff 
 4741 Sharpstone Lane 
 Raleigh, NC 27615 
 Re: Purchase of Pharma Shares 
 Dear John, 

On July 15, 2004 you were offered the opportunity to purchase shares of common stock of Pharma Services Holding, Inc. for $0.2438 per share. In
connection with the tax liability to you resulting from your purchase of the shares, Quintiles will pay to you the amount of $109,288.67. You remain responsible for any further tax liability whether or not this additional payment to you fully
addresses your tax liability. 
 We recommend that you seek advice from your personal tax advisor regarding the payment. 

If you have any questions, please contact me at 919-998-2018. 
 Sincerely, 
 Nicky Rousseau 
 V.P., Global Compensation and BenefitsLetter, dated February 22, 2005, to John D. Ratliff

 Exhibit 10.46 
 (QUINTILES TRANSNATIONAL CORP. LOGO) 
 Quintiles Transnational
Corp. 
 Post Office Box 13979 

Research Triangle Park, NC 27709-3979 918 

998 2000 / Fax 919 998 9113 
 http://www.quintiles.com 
 February 22, 2005 

John Ratliff 
 4741 Sharpstone Lane 

Raleigh, NC 27615 
 Re: Purchase of Pharma
Shares 
 Dear John, 
 On
February 4, 2005 you were offered the opportunity to purchase shares of common stock of Pharma Services Holding, Inc. for $0.2438 per share. On February 8, you accepted the offer, purchased the shares and filed an 83(b) election. In
connection with the potential tax liability to you resulting from your election, Quintiles will pay to you the amount of $118,758.35. You remain responsible for any personal tax liability whether or not this additional payment to you fully addresses
your tax liability. 
 We recommend that you seek advice from your personal tax advisor regarding the payment. 

If you have any questions, please contact me at 919-998-2018. 
 Sincerely, 
  

					
	 /s/ Nicky Rousseau
	 	
		
	 Nicky Rousseau
	 	
	 V.P., Global Compensation and BenefitsLetter, dated December 6, 2004, to John D. Ratliff

 Exhibit 10.47 
 (QUINTILES TRANSNATIONAL CORP. LOGO) 
 Quintiles Transnational
Corp. 
 Post Office Box 13979 

Research Triangle Park, NC 27709-3979 

918 998 2000 / Fax 919 998 9113 
 http://www.quintiles.com 
 December 6, 2004 

John Ratliff 
 QTRN 

Re: Purchase of Pharma Shares 
 Dear John,

 On July 15, 2004 you were offered the opportunity to purchase shares of common stock of Pharma Services Holding, Inc. for $0.2438 per
share. In connection with potential tax liability to you resulting from your purchase of the shares, Quintiles will pay to you the amount of $204,096.33. You remain responsible for any personal tax liability whether or not this additional payment to
you fully addresses your tax liability. 
 We recommend that you seek advice from your personal tax advisor regarding the payment and discuss
with us by December 10, the related tax and withholding issues. You also should consider whether any changes are appropriate with respect to the 83(b) election you made in connection with the purchase. 

If you have any questions, please contact me at 919-998-2517. 
 Sincerely, 
  

					
	 /s/ Denise J. Eller
	 	
		
	 Denise J. Eller, CEBS
	 	
	 Associate Director, Global Compensation & BenefitsExecutive Employment Agreement, dated June 1, 2003

 Exhibit 10.48 
 (QUINTILES TRANSNATIONAL CORP. LOGO) 
 EXECUTIVE EMPLOYMENT AGREEMENT

 This Executive Employment Agreement (“Agreement”), dated as of JUNE 1, 2003, is made and entered into by
QUINTILES TRANSNATIONAL CORP. a North Carolina corporation (hereinafter the “Company”) and MICHAEL MORTIMER (hereinafter the “Executive”). The Company desires to employ Executive as its EXECUTIVE, VICE PRESIDENT GLOBAL HUMAN
RESOURCES and provide adequate assurances to Executive and Executive desires to accept such employment on the terms set forth below, which terms Executive agreed to in Executive’s offer letter. 

In consideration of the mutual promises set forth below and other good and valuable new consideration, the receipt and sufficiency of
which the parties acknowledge, the Company and Executive agree as follows: 
  

	 	1.	EMPLOYMENT. The Company employs Executive and Executive accepts employment on the terms and conditions set forth in this Agreement and the offer letter dated June, 10,
2003, a copy of which is appended hereto and the terms of which are incorporated herein. 

 2.
    NATURE OF EMPLOYMENT. Executive shall serve as EXECUTIVE VICE PRESIDENT, GLOBAL HUMAN RESOURCES, reporting directly to the Chairman, and have such responsibilities and authority as the Company may assign from time to time.
Additionally, Executive agrees to perform such other duties consonant with those of an executive at his level as the Company may set from time to time. 
 2.1 Executive shall perform all duties and exercise all authority in accordance with, and shall otherwise comply with, all Company policies, procedures, practices and reasonable directions. 

2.2 Executive shall devote all working time, best efforts, knowledge and experience to perform successfully his duties and advance the
Company’s and/or its Affiliates’ interests. During his employment, Executive shall not engage in any other business activities of any nature whatsoever (including board memberships) for which he receives compensation without the
Company’s prior written consent; provided, however, this provision does not prohibit him from personally owning and trading in stocks, bonds, securities, real estate, commodities or other investment properties for his own benefit, which do not
create actual or potential conflicts of interest with the Company and/or its Affiliates. As used in this Agreement, “Affiliates” shall mean: (i) any Company’s parent, subsidiary or related entity; and/or (ii) any entity
directly or 

  
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indirectly controlled or beneficially owned in whole or part by the Company or Company’s parent, subsidiary or related entity. 

2.3 Executive’s base of operation shall be Research Triangle Park, North Carolina, subject to business travel as may be necessary in
the performance of Executive’s duties. 
 3.     COMPENSATION. 

3.1 BASE SALARY. Executive’s annual salary for all services rendered shall be $350,000 (less applicable withholdings), payable in
accordance with the Company’s policies, procedures and practices as they may exist from time to time. Executive’s salary shall be reviewed in accordance with the Company’s policies, procedures and practices as they may exist from time
to time. 
 3.2 EXECUTIVE COMPENSATION PLAN. Executive may participate as a Level 2.0 employee in the Executive Compensation
Plan (or successor plans) (“ECP”) which may be made available from time to time to Company executives at Executive’s level; provided, however, that Executive’s participation is subject to the applicable terms, conditions and
eligibility requirements of the plan documents, some of which are within the plan administrator’s discretion, as they may exist from time to time; provided, however, that Executive must be treated the same as Company executives at
Executive’s level. 
 3.3 TAX RETURNS. Executive shall be entitled to tax return preparation and reasonable financial
planning, consultation and advice by the Company’s accounting firm and/or legal counsel and/or financial consultants as Executive chooses consistent with Company policy and in an amount capped for all Company executives at Executive’s
level. 
 3.4 OTHER BENEFITS. Executive may participate in all available medical, dental and disability insurance, 401(k),
pension, personal leave, car allowance and other employee benefit plans and programs, except Executive may not receive severance payments other than specified in this Agreement; provided, however, that Executive’s participation in benefit plans
and programs is subject to the applicable terms, conditions and eligibility requirements of these plans and programs, some of which are within the plan administrator’s discretion, as they may exist from time to time. 

3.5 BUSINESS EXPENSES. Executive shall be reimbursed for reasonable and necessary expenses actually incurred by him/her in performing
services under this Agreement in accordance with and subject to the terms and conditions of the applicable Company reimbursement policies, procedures and practices as they may exist from time to time. Expenses

  
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covered by this provision include but are not limited to travel, entertainment, professional dues, subscriptions and dues, fees and expenses associated with membership in various professional,
and business and civic associations of which Executive’s participation is in the Company’s best interest. 
 3.6
Nothing in this Agreement shall require the Company to create, continue or refrain from amending, modifying, revising or revoking any of the plans, programs or benefits set forth in Sections 3.2 through 3.5. Any amendments, modifications, revisions
and revocations of these plans, programs and benefits shall apply to Executive. 
 3.7 If, at any time during which Executive is
receiving salary or post-termination payments from the Company, he receives payments on account of mental or physical disability from any Company-provided plan, then the Company, at its discretion, may reduce his salary or post-termination payments
by the amount of such disability payments. 
 4.     TERM OF EMPLOYMENT. The original term of employment
shall be for a one (1) year period commencing on July 14, 2003, and terminating on July 14, 2004, subject to the following provisions: 
 4.1 Upon the expiration of the original or any renewal term of employment, Executive’s employment shall be automatically renewed for an additional one (1) year period unless, at least ninety
(90) days prior to the renewal date, either party gives the other party written notice of its intent not to continue the employment relationship. During any renewal term of employment, the terms, conditions and provisions set forth in this
Agreement shall remain in effect unless modified in accordance with Section 14. 
 4.2 Either party may terminate the
employment relationship without cause at any time upon giving the other party ninety (90) days’ written notice. 
 4.3
The Company may terminate the Executive’s employment relationship immediately without notice at any time for the following reasons which shall constitute “Cause”: (i) Executive’s death; (ii) Executive’s physical or
mental inability to perform the essential functions of his duties satisfactorily for a period of 180 consecutive days or 180 days in total within a 365-day period as determined by an independent physician and in accordance with applicable law;
(iii) any act or omission of Executive constituting willful misconduct (including willful violation of the Company’s policies), gross negligence, fraud, misappropriation, embezzlement, criminal behavior, conflict of interest or competitive
business activities which, as determined by the Company in its reasonable discretion, shall cause material harm, or any other actions that are materially detrimental to the Company or any Affiliates’ interest; (iv or
(iv)

  
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Executive’s material breach of this Agreement With respect to (iii) and (iv) above, the Company may terminate the Executive for Cause only after the Executive’s failure to
cure his material breach of this Agreement after the Company has given the Executive notice of the material breach and at least thirty (30) days to cure the breach (or such longer period as may be reasonably required to cure the breach as long
as the Executive is making good faith efforts to do so). The Executive shall have the right to contest the Company’s termination of the Executive for Cause in which event such termination shall be deemed effective only after it has been
affirmed by an impartial tribunal or court of competent jurisdiction. In any such action or proceeding, the prevailing party shall be awarded his/its reasonable costs and attorneys’ fees. 

4.4 Executive may terminate Executive’s employment with the Company as a result of the Company’s failure to cure its material
breach of this Agreement after Executive has given the Company notice of the material breach and at least thirty (30) days to cure the breach (or such longer period as may be reasonably required to cure the breach as long as the Company is
making good faith efforts to do so). The Company shall have the right to contest the Executive’s termination of his employment under this Section 4.4 in which event such termination shall be deemed effective only after it has been affirmed
by an impartial tribunal or court of competent jurisdiction. In any such action or proceeding, the prevailing party shall be awarded his/its reasonable costs and attorneys’ fees. 

4.5 This Agreement shall terminate upon the termination of the employment relationship with the following exceptions: Section 6
(Trade Secrets, Confidential Information, Company Property and Competitive Business Activities), 7 (Intellectual Property Ownership), 8 (License), 9 (Release), and shall survive the termination of Executive’s employment and/or the expiration or
termination of this Agreement, regardless of the reasons for such expiration or termination. 
 5.
    COMPENSATION AND BENEFITS UPON TERMINATION. 
 5.1 The Company’s obligation to compensate Executive
ceases on the effective termination date except as to: (i) amounts due at that time; (ii) any amount subsequently due pursuant to the plan described in Section 3.2; and (iii) any compensation and/or benefits to which he may be
entitled to receive pursuant to Sections 5.2,5.3,5.4 or 5.5. 
 5.2 If the Company terminates Executive’s employment
pursuant to Sections 4.1 (notice of non-renewal) or 4.2 (without cause), then the Company’s sole obligation shall be to pay Executive: (i) amounts due on the effective termination date; (ii) any amounts subsequently due pursuant to
the plan described in Section 3.2; and (iii) subject to Executive’s compliance with 

  
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Sections 6,7,8 and 9 and subject to Sections 3.7 and 5.6, an amount equal to his then current monthly salary (less applicable withholdings) for eighteen (18) months, decreasing to twelve
(12) months after two (2) full years of employment, payable in equal monthly installments. The Executive shall have no duty to mitigate with respect to his entitlement to or receipt of any payment described in this Section 5.2

 5.3 During the period during which Executive receives post-termination payments pursuant to Section 5.2, he may continue
to participate, to the extent permitted by the applicable plans and subject to their terms, conditions and eligibility requirements, in all employee welfare benefits plans (as defined by the Employee Retirement Income Security Act of 1974, as
amended) in which Executive participated on his effective termination date. The Company will pay or, at the Company’s discretion, reimburse Executive for the premiums actually paid, to continue coverage under such plans during the period.
Notwithstanding the Company’s payment of or reimbursement for the premiums, any coverage under such plans shall be subject to the terms, conditions and eligibility requirements of such plans, and nothing in this Section shall constitute any
guaranty of coverage. 
 5.4 If the Company terminates Executive’s employment as provided in Sections 4.3 (i) (death),
(ii) (physical or mental inability to perform), (iii) (materially harmful acts or omissions), or (iv) (Executive’s material breach) or if the Executive terminates his employment pursuant to Section 4.1 (notice of
non-renewal) or Section 4.2 (without cause), then the Company’s sole obligation shall be to pay Executive: (i) amounts due on the effective termination date and (ii) any amounts subsequently due pursuant to the plan described in
Section 3.2. Executive, except when employment terminates pursuant to Section 4.3(i) (death), shall comply with Sections 6,7,8 and 9 of this Agreement upon expiration or termination of this Agreement. 

5.5 If Executive terminates the employment relationship as a result of the Company’s failure to cure its material breach of this
Agreement after he has given the Company notice of the material breach and 30 days in which to cure the breach (or such longer period as may be reasonably required to cure the breach as long as the Company is making good faith efforts to do so),
pursuant to Section 4.4 of this Agreement, then the Company’s sole obligation to Executive in lieu of any other damages or other relief to which he otherwise may be entitled shall be (i) an amount equal to amounts due at the time of
his termination; and (ii) subject to Executive’s compliance with Sections 6, 7, 8 and 9 and subject to Sections 3.7 and 5.6, continued payments in an amount equal to his then current monthly salary (less applicable withholdings) for
eighteen (18) months., decreasing to twelve (12) months after two (2) full years of employment, payable in equal monthly installments. The Executive shall have no duty to mitigate with respect to his entitlement to or receipt of any
payment described in this Section 5.5. 

  
 5 

 5.6 The Company’s obligation to provide the payments under Sections 5.2 and 5.5 is
conditioned upon Executive’s execution of an enforceable release of all claims and his compliance with Sections 6, 7, 8 and 9 of this Agreement. If Executive chooses not to execute such a release or fails to comply with these sections, then the
Company’s obligation to compensate him/her ceases on the effective termination date except as to amounts due at that time and any amount subsequently due pursuant to the plan described in Section 3.2. 

5.7 Executive is not entitled to receive any compensation or benefits upon his termination except as: (i) set forth in this
Agreement; (ii) otherwise required by law; or (iii) otherwise required by any employee benefit plan in which he participates. Nothing in this Agreement, however, is intended to waive or supplant any death, disability, retirement, 401(k) or
pension benefits to which he may be entitled under employee benefit plans in which he participates. 
 6.
    TRADE SECRETS, CONFIDENTIAL INFORMATION, COMPANY PROPERTY AND COMPETITIVE BUSINESS ACTIVITIES. Executive acknowledges that: (i) the Company and its Affiliates have worldwide business operations, a worldwide customer
base, and are engaged in the business of contract research, sales and marketing, healthcare policy consulting and health information management services to the worldwide pharmaceutical, biotechnology, medical device and healthcare industries;
(ii) by virtue of his employment by and upper-level position with the Company, he has or will have access to Trade Secrets and Confidential Information (as defined in Sections 6.1(5) and 6.1(6)) of the Company and its Affiliates, including
valuable information about their worldwide business operations and entities with whom they do business in various locations throughout the world, and has developed or will develop relationships with their customers and others with whom they do
business in various locations throughout the world; and (iii) the Trade Secret, Confidential Information and Competitive Business Activities’ provisions set forth in this Agreement are reasonably necessary to protect the Company’s and
its Affiliates’ legitimate business interests, are reasonable as to the time, territory and scope of activities which are restricted, do not interfere with public policy or public interest and are described with sufficient accuracy and
definiteness to enable him/her to understand the scope of the restrictions imposed on him/her. 
 6.1 TRADE SECRETS AND
CONFIDENTIAL INFORMATION. Executive acknowledges that: (i) the Company and/or its Affiliates will disclose to him/her certain Trade Secrets and Confidential Information; (ii) Trade Secrets and Confidential Information are the sole and
exclusive property of the Company and/or its Affiliates (or a third party providing such information to the Company and/or its Affiliates) and the Company and/or its Affiliates or such 

  
 6 

 
third party owns all worldwide rights therein under patent, copyright, trademarks, trade secret, confidential information or other property right; and (iii) the disclosure of Trade Secrets
and Confidential Information to Executive does not confer upon him/her any license, interest or rights of any kind in or to the Trade Secrets or Confidential Information. 
 6.1(1) Executive may use the Trade Secrets and Confidential Information only while he is employed or otherwise retained by the Company and only then in accordance with applicable Company policies and
procedures and solely for the Company’s benefit. Except as authorized in the performance of services for the Company, Executive will hold in confidence and will not, either or indirectly, in any form, by any means, or for any purpose, disclose,
reproduce, distribute, transmit, reverse engineer, decompile, disassemble, or transfer Trade Secrets or Confidential Information or any portion thereof. Upon the Company’s request, Executive shall return Trade Secrets and Confidential
Information and all related materials. 
 6.1(2) If Executive is required to disclose Trade Secrets or Confidential Information
pursuant to a court order, subpoena or other government process or such disclosure is necessary to comply with applicable law or defend against claims, he shall: (i) notify the Company promptly before any such disclosure is made; (ii) at
the Company’s request and expense take all reasonably necessary steps to defend against such disclosure, including defending against the enforcement of the court order, other government process or claims; and (iii) permit the Company to
participate with counsel of its choice in any proceeding relating to any such court order, subpoena, other government process or claims. 
 6.1(3) Executive’s obligations with regard to Trade Secrets shall remain in effect for as long as such information shall remain a trade secret under applicable law. 

6.1(4) Executive’s obligations with regard to Confidential Information shall remain in effect while he is employed or otherwise
retained by the Company and/or its Affiliates and for fifteen (15) years thereafter. 
 6.1(5) As used in this Agreement,
“Trade Secrets” means information of the Company, its Affiliates and its and/or their licensors, suppliers, customers, or prospective licensors or customers, including, but not limited to, data, formulas, patterns, compilations, programs,
devices, methods, techniques, processes, financial data, financial plans, product plans, or lists of actual or potential customers or suppliers, which: (i) derives independent actual or potential commercial value, from not being generally known
to or readily ascertainable through independent development or reverse engineering by persons or entities who can obtain economic value from its disclosure or use; and (ii) is the subject of efforts that are reasonable under the circumstances
to maintain its secrecy. 

  
 7 

 6.1(6) As used in this Agreement, “Confidential Information” means information
other than Trade Secrets, that is of value to its owner and is treated as confidential, including, but not limited to, future business plans, licensing strategies, advertising campaigns, information regarding executives and employees, and the terms
and conditions of this Agreement; provided, however, Confidential Information shall not include information which is in the public domain or becomes public knowledge through no fault of Executive. 

6.2 COMPANY PROPERTY. Upon termination of his employment, Executive shall: (i) deliver to the Company all records, memoranda, data,
documents and other property of any description which refer or relate in any way to Trade Secrets or Confidential Information, including all copies thereof, which are in his possession, custody or control; (ii) deliver to the Company all
Company and/or Affiliates property (including, but not limited to, keys, credit cards, client files, contracts, proposals, work in process, manuals, forms, computer stored work in process and other computer data, research materials, other items of
business information concerning any Company and/or Affiliates client, or Company and/or Affiliates business or business methods, including all copies thereof) which is in his possession, custody or control; (iii) bring all such records, files
and other materials up to date before returning them and bill the Company for any work outside his daily job duties if bringing these materials up to date requires Executive to perform services beyond the termination date; and (iv) fully
cooperate with the Company in winding up his work and transferring that work to other individuals designated by the Company. 

6.3 COMPETITIVE BUSINESS ACTIVITIES. During his employment and the one (1) year following his effective termination date (regardless
of the reason for the termination), Executive will not engage in the following activities: 
 (A) on Executive’s own or
another’s behalf, whether as an officer, director, stockholder, partner, associate, owner, employee, consultant or otherwise, directly or indirectly: 
 (i) compete with the Company or its Affiliates within the geographical areas set forth in Section 6.3(1); except that Executive, without violating this provision, may become employed by any company
which is engaged in the integrated development, discovery, manufacture, marketing and sale of pharmaceutical drugs that does not engage in contract sales and/or research; 
 (ii) within the geographical areas set forth in Section 6.3(1), solicit or do business which is the same, similar to or otherwise in competition with the business

  
 8 

 
engaged in by the Company or its Affiliates, from or with persons or entities: 
 (A) who are customers of the Company or its Affiliates; (B) who Executive or someone for whom he was responsible solicited, negotiated, contracted or serviced on the Company’s or its
Affiliates’ behalf: or (C) who were customers of the Company or its Affiliates at any time during the last year of Executive’s employment with the Company; 
 (iii) offer employment to or otherwise solicit for employment any employee or other person who had been employed by the Company or its Affiliates during the last year of Executive’s employment with
the Company; or 
 (B) directly or indirectly take any action which is materially detrimental or otherwise intended to be
adverse to the Company’s and/or Affiliates’ goodwill, name, business relations, prospects and operations. 
 6.3(1)
The restrictions set forth in Section 6.3 apply to the following geographical areas; (i) within a 60-mile radius of the location of the Company where the Executive had an office during the Executive’s employment with the Company;
(ii) any city, metropolitan area, county (or similar political subdivision in foreign countries) in which Executive’s substantial services were provided, or for which Executive had substantial responsibility, or in which Executive
performed substantial work on Company and/or Affiliates’ projects, while employed by the Company; and (iii) any city, metropolitan area, county (or similar political subdivisions in foreign countries) in which the Company or its Affiliates
is located or does or, during Executive’s employment with Company, did business. 
 6.3(2) Not withstanding the foregoing,
Executive’s ownership, directly or indirectly, of not more than one percent of the issued and outstanding stock of a corporation the shares of which are regularly traded on a national securities exchange or in the over-the-counter market shall
not violate Section 6.3. 
 6.4 REMEDIES. Executive acknowledges that his failure to abide by the Trade Secrets,
Confidential Information, Company Property or Competitive Business Activities provisions of this Agreement would cause irreparable harm to the Company and/or its Affiliates for which legal remedies would be inadequate. Therefore, in addition to any
legal or other relief to which the Company and/or its Affiliates may be entitled by virtue of Executive’s failure to abide by these provisions: (i) the Company will be released of its obligations under this Agreement to make any
post-termination payments, including but not limited to those otherwise available pursuant to Sections 5.2, 5.3, 5.4, 5.5; (ii) the Company may seek legal and equitable relief, including but not limited to preliminary and permanent injunctive
relief, for Executive’s actual or threatened failure to abide by these provisions; (iii) Executive will return all post-termination 

  
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payments received pursuant to this Agreement, including but not limited to those received pursuant to Sections 5.2, 5.3, 5.4, 5.5;; and (iv) if, as a result of Executive’s failure to
abide by the Trade Secrets, Confidential Information, Company Property or Competitive Business Activities provisions, any commission or fee becomes payable to Executive or to any person, corporation or other entity with which Executive has become
employed or otherwise associated. Executive shall pay the Company or cause the person, corporation or other entity with whom he has become employed or otherwise associated to pay the Company an amount equal to such commission or fee. In the event
that the Company exercises its right to discontinue payments under this provision and/or Executive returns all post-termination payments received pursuant to this Agreement, Executive shall remain obligated to abide by the Trade Secrets,
Confidential Information, Company Property and Competitive Business Activities provisions set forth in this Agreement. 
 6.5
TOLLING. The period during which Executive must refrain from the activities set forth in Sections 6.1 and 6.3 shall be tolled during any period in which he fails to abide by these provisions. 

6.6 OTHER AGREEMENTS. Nothing in this Agreement shall terminate, revoke or diminish Executive’s obligations or the Company’s
and/or its Affiliates’ rights and remedies under law or any agreements relating to trade secrets, confidential information, non-competition or intellectual property which Executive has executed in the past or may execute in the future or
contemporaneously with this Agreement. 
 7.     INTELLECTUAL PROPERTY OWNERSHIP. 

7.1 As used in this Agreement, “Work Product” shall mean the data, materials, documentation, computer programs, inventions
(whether or not patentable), improvements, modifications, discoveries, methods, developments, picture, audio, video, artistic works and all works of authorship, including all worldwide rights therein under patent, copyright, trademark, trade secret,
confidential information or other property right, created or developed in whole or in part by Executive, while employed by the Company (whether developed during work hours or not), whether prior or subsequent to the date of this Agreement.

 7.2 All Work Product shall be considered work made for hire by Executive and owned by the Company. If any of the Work Product
may not, by operation of law be considered work made for hire by Executive for the Company, or if ownership of all right, title, and interest of the intellectual property rights therein shall not otherwise vest exclusively in the Company, Executive
hereby assigns to the Company, and upon the future creation thereof automatically assigns to the Company, without further consideration, the ownership of all Work Product. The 

  
 10 

 
Company shall have the right to obtain and hold in its own name copyrights, registrations and any other protection available in the Work Product. Executive agrees to perform, during or after his
employment, such further acts which the Company requests as may be necessary or desirable to transfer, perfect and defend its ownership of the Work Product. 
 7.3 Notwithstanding the foregoing, this Agreement shall not require assignment of any invention that: (i) Executive developed entirely on his own time without using the Company’s equipment,
supplies, facilities, Trade Secrets or Confidential Information; and (ii) does not relate to the Company’s business or actual or anticipated research or development or result from any work performed by Executive for the Company.

 7.4 Executive shall promptly disclose to the Company in writing all Work Product conceived, developed or made by him/her,
individually or jointly. 
 8.     LICENSE. To the extent that any preexisting materials are contained in
Work Product which Executive delivers to the Company or its customers, Executive grants to the Company an irrevocable, nonexclusive, worldwide, royalty-free license to: (i) use and distribute (internally or externally) copies of, and prepare
derivative works based upon, such preexisting materials and derivative works thereof; and (ii) authorize others to do any of the foregoing. 
 9.     RELEASE. Executive acknowledges that: (i) as a part of his services, he may provide his image, likeness, voice or other characteristics; and (ii) the Company may use
his image, likeness, voice or other characteristics and expressly releases the Company, its Affiliates and its and/or their agents, employees, licensees and assigns from and against any and all claims which he has or may have for invasion of
privacy, right of privacy, copyright infringement or any other causes of action arising out of the use, adaptation, reproduction, distribution, broadcast or exhibition of such characteristics. 

10.   EMPLOYEE REPRESENTATION. Executive represents and warrants that his employment and obligations under this Agreement will
not breach any duty or obligation he owes to another. 
 11.   OFFICERS AND DIRECTORS INDEMNIFICATION PROVISIONS. To
the extent Executive serves as a Company and/or Affiliate officer or director, Executive shall be entitled to insurance under Company’s directors and officers’ indemnification policies comparable to any such insurance covering executives
of the applicable entity serving in similar capacities. Further, the Company’s bylaws shall contain provisions granting to Executive the maximum indemnity protection allowed under applicable law and the Company hereby agrees to indemnify

  
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and hold harmless Executive in accordance with such maximum indemnity protection allowed under applicable law. 
 12.   NOTICES. All notices, requests, demands and other communications required or permitted to be given in writing pursuant to this Agreement shall be deemed given and received: (A) upon
delivery if delivered personally; (B) on the fifth (5th) day after being deposited with the U.S. Postal Service if mailed by first class mail, postage prepaid, registered or certified with return receipt requested, at the addresses set
forth below; (C) on the next day after being deposited with a reliable overnight delivery service; or (D) upon receipt of an answer back confirmation, if transmitted by telefax, addressed to the below indicated telefax number. Notice given
in another manner shall be effective only if and when received by the addressee. For purposes of notice, the addresses and telefax number (if any) of the parties shall be as follows: 

 

							
		 	If to the Executive, to:	  	Michael Mortimer	  	
		 		  	201 Cross Bridge Drive	  	
		 		  	Danville, CA 94526	  	
				
		 	With a copy to:	  	Jeffrey P. Englander, Esq.	  	
		 		  	Morrison Cohen Singer & Weinstein, LLP	  	
		 		  	750 Lexington Avenue	  	
		 		  	New York, NY 10022	  	
				
		 	If to the Company, to:	  	Quintiles Transnational Corp.	  	
		 		  	4709 Creekstone Drive	  	
		 		  	Riverbirch Building, Suite 300	  	
		 		  	Durham, North Carolina 27703-8411	  	
		 		  	Attn: General Counsel	  	

 provided that: (A) each party shall have the right to change its address for notice, and the person who is to
receive notice, by the giving of fifteen (15) days’ prior written notice to the other party in the manner set forth above; and (B) notices shall be effective if given to the other party in the manner set forth above regardless of
whether a copy was received by the additional addressee specified above. 
 13.   WAIVER OF BREACH. The Company’s
or Executive’s waiver of any breach of a provision of this Agreement shall not waive any subsequent breach by the other party. 

  
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 14.   ENTIRE AGREEMENT. Except as expressly provided in this Agreement, this
Agreement: (i) supersedes all other understandings and agreements, oral or written, between the parties with respect to the subject matter of this Agreement; and (ii) constitutes the sole agreement between the parties with respect to this
subject matter. Each party acknowledges that: (i) no representations, inducements, promises or agreements, oral or written, have been made by any party or by anyone acting on behalf of any party, which are not embodied in this Agreement; and
(ii) no agreement, statement or promise not contained in this Agreement shall be valid. No change or modification of this Agreement shall be valid or binding upon the parties unless such change or modification is in writing and is signed by the
parties. 
 15.   SEVERABILITY. If a court of competent jurisdiction holds that any provision or sub-part thereof
contained in this Agreement is invalid, illegal or unenforceable, that invalidity, illegality or unenforceability shall not affect any other provision in this Agreement. Additionally, if any of the provisions, clauses or phrases in the Trade
Secrets, Confidential Information or Competitive Business Activities provisions set forth in this Agreement are held unenforceable by a court of competent jurisdiction, then the parties desire that they be “blue-penciled” or rewritten by
the court to the extent necessary to render them enforceable. 
 16.   PARTIES BOUND. The terms, provisions, covenants
and agreements contained in this Agreement shall apply to, be binding upon and inure to the benefit of the Company’s successors and assigns. The Company, at its discretion, may assign this Agreement to Affiliates. Because this Agreement is
personal to Executive, Executive may not assign this Agreement. 
 17.   GOVERNING LAW. This Agreement and the
employment relationship created by it shall be governed by North Carolina law without giving effect to North Carolina choice of law provisions. The parties hereby consent to jurisdiction in North Carolina for the purpose of any litigation relating
to this Agreement and agree that any litigation by or involving them relating to this Agreement shall be conducted in the courts of Wake County, North Carolina or the federal courts of the United States for the Eastern District of North Carolina.

 IN WITNESS WHEREOF, the parties have entered into this Agreement on the day and year first written above. 

  
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	 /s/ Michael Mortimer

	 Michael Mortimer

	
	Quintiles Transnational Corp.
		
	By:	 	 /s/ Beverly Rubin

	Title:	 	 SVP, Deputy General Counsel

  
 14

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