Document:

Exhibit
10.48

    

    

    SECOND AMENDMENT TO
DEVELOPMENT

    AND COMMERCIALIZATION
AGREEMENT

    

    

    THIS SECOND AMENDMENT TO DEVELOPMENT
AND COMMERCIALIZATION AGREEMENT (this “Second Amendment”) is made as of the
17th
day of November, 2009, by and between Artann Laboratories, Inc. (“Artann”), a
New Jersey corporation and ProUroCare Medical Inc. (“ProUroCare”), a Nevada
corporation.

    

    RECITALS

    

    A.           Artann
and ProUroCare (“the Parties”) entered into a development and commercialization
agreement on July 25, 2008 relating to a prostate mechanical imaging system
(“the Development and Commercialization Agreement”).

    

    B.           The
Parties entered into an amendment to that Development and Commercialization
Agreement on December 20, 2008 (the “First Amendment”).

    

    C.           The
Parties now wish to amend the Development and Commercialization Agreement and
the First Amendment thereto as provided herein.

    

    Now, therefore, in consideration of the
covenants and agreements set forth herein and for valuable consideration,
receipt of which is hereby acknowledged, the Parties mutually agree as
follows:

    

    AGREEMENT

    

    ARTICLE
I

    DEFINITIONS

    

    Terms used in this Second Amendment
have the meanings ascribed thereto in the Development and Commercialization
Agreement and First Amendment thereto.

    

    ARTICLE
II

    AMENDMENTS

    

    2.1           Section
3.2 of the Development and Commercialization Agreement shall be amended and
restated to read in its entirety as follows:

    

    “3.2           Equity.  ProUroCare
shall provide equity (i.e., shares of stock) in ProUroCare upon 1) submission of
a 510(k) or PMA as outlined in Section 2.3 on the Generation V PMI System (the
“510(k)”), or 2) March 15, 2010, whichever is later.  The equity
provided shall be as follows:

     

    
      
         

      

      
         

        
          

        

      

      
         

      

    

    
 

    a)
769,231 shares, if the 510(k) is duly filed with FDA by November 26,
2009;

    b)
666,667 shares, if the 510(k) is duly filed with FDA by December 15,
2009;

    c)
588,235 shares, if the 510(k) is duly filed with FDA by December 31, 2009;
or

    d)
526,316 shares, if the 510(k) is duly filed with FDA after January 1,
2010.”

    

    IN
WITNESS THEREOF, the Parties, intending to be legally bound, have caused this
Amendment to be executed by their duly authorized officers, as of the effective
date of this Amendment.

    

    

    
      	
              PROUROCARE
      MEDICAL, INC.

            	
              ARTANN
      LABORATORIES, INC.

            	 
      
	 
      	 
      	 
      
	 
      	 
      	 
      
	
              By:
      /s/ Richard C.
      Carlson

            	
              By:
      /s/ Noune
      Sarvazyan

            	 
      
	 
      	 
      	 
      
	 
      	 
      	 
      
	
                  
          Richard C.
      Carlson        

            	
                 
             Noune
      Sarvazyan         
      

            	 
      
	
              (Print
      or Type Name)

            	
              (Print
      or Type Name)

            	 
      
	 
      	 
      	 
      
	
              Title:
      Chief Executive
      Officer

            	
              Title:
      Chief Executive
      Officer

            	 
      

    

    

     

    
      
         

      

      
         

        
          

        

      

      
        2Exhibit
10.49

    

     

     

    

    
      	
              SUPREME
      COURT OF THE STATE OF NEW YORK

            	 
      
	
              COUNTY
      OF RENSSELAER

            	 
      
	
              

                _____________________________________________________

              

            	 
      
	 
      	 
      	 
      
	
              RENSSELAER
      POLYTECHNIC INSTITUTE,

            	 
      
	 
      	 
      	 
      
	 
      	
              Plaintiff,

            	
              SETTLEMENT
      AGREEMENT

            
	 
      	 
      	 
      
	
              -
      against -

            	 
      	 
      
	 
      	 
      	
              Index
      No.: 229806

            
	 
      	 
      	 
      
	
              PRO
      URO CARE INC. and PROUROCARE

            	 
      
	
              MEDICAL,
      INC.,

            	 
      
	 
      	 
      	 
      
	 
      	
              Defendants.

            	 
      
	
              _____________________________________________________

            	 
      

    

    

    This sets
forth a settlement agreement (the “Agreement”), effective as of the date
executed by all parties hereto, by and between Plaintiff Rensselaer Polytechnic
Institute (“Plaintiff”) and Defendants Pro Uro Care Inc. and ProUroCare Medical
Inc.  (“Defendants”) (together, the “parties”). 

     

    WHEREAS, Plaintiff commenced
the above-captioned action against Defendants alleging claims for breach of
contract and account stated, and seeking damages in the principal amount of
$202,716.04,  plus all applicable interest and penalties, based on
Defendants’ alleged failure to pay amounts due to Plaintiff from Defendants (the
“Action”); and

     

    WHEREAS, Defendants timely
answered Plaintiff’s Complaint, denied the amount of damages claimed by
Plaintiff, and asserted various affirmative defenses; and

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

    WHEREAS, Defendants contend
that ProUroCare Medical Inc. is not a proper party to this Action;
and

     

    WHEREAS, Defendants contend
that the Parties had previously contractually agreed that Plaintiff’s claims
were to be resolved by arbitration; and

     

    WHEREAS, the parties have
determined to resolve the matters in dispute without resort to further
litigation, on the terms set forth herein.

     

    NOW, THEREFORE, in consideration of
the promises and mutual undertakings of the parties set forth herein, the
sufficiency of which is acknowledged by the parties, the parties hereby agree as
follows:

     

    1. Payment:  In
consideration of the covenants contained in this Agreement, Pro Uro Care Inc.
agrees to pay to Plaintiff the total sum of One Hundred Seventeen Thousand
Dollars ($117,000).   Said payment shall be made as
follows: 

     

    
      	
              (A)      
      

            	
              An
      initial payment of Ten Thousand Dollars ($10,000.00) due upon Defendants
      execution and return of this Agreement to Plaintiff’s
    counsel;

            

    

    
      	
              (B)      

            	
              A
      second payment of Six Thousand Dollars ($6,000) due on or before December
      15, 2009; 

            

    

    
      	
              (C)      

            	
              A
      third payment of Six Thousand Dollars ($6,000) due on or before January
      15, 2010;

            

    

    
      	
              (D)      

            	
              A
      fourth payment of Six Thousand Dollars ($6,000) due on or before February
      15, 2010;

            

    

    
      	
              (E)      

            	
              A
      fifth payment of Six Thousand Dollars ($6,000) due on or before March 15,
      2010;

            

    

     

    
      
        
        

      

      
        2

        
          

        

      

      
        
        

      

    

     

    
      	
              (F)      

            	
              A
      sixth payment of Six Thousand Dollars ($6,000) due on or before April 15,
      2010;

            

    

    
      	
              (G)      

            	
              A
      seventh payment of Six Thousand Dollars ($6,000) due on or before May 15,
      2010;

            

    

    
      	
              (H)      

            	
              An
      eighth payment of Six Thousand Dollars ($6,000) due on or before June 15,
      2010;

            

    

    
      	
              (I)      

            	
              A
      ninth payment of Six Thousand Dollars ($6,000) due on or before July 15,
      2010;

            

    

    
      	
              (J)      

            	
              A
      tenth payment of Six Thousand Dollars ($6,000) due on or before August 15,
      2010;

            

    

    
      	
              (K)      

            	
              An
      eleventh payment of Six Thousand Dollars ($6,000) due on or before
      September 15, 2010;

            

    

    
      	
              (L)      

            	
              A
      twelfth payment of Six Thousand Dollars ($6,000) due on or before October
      15, 2010;

            

    

    
      	
              (M)      

            	
              A
      final payment of Forty-One Thousand Dollars ($41,000) due on or before
      November 15, 2010.

            

    

     

    All
payments shall be made to Plaintiff by check made payable to “Rensselaer
Polytechnic Institute” and delivered to Plaintiff’s counsel, unless Plaintiff or
its counsel shall otherwise direct in writing.  In the event that any
payment is not received by Plaintiff’s counsel on or before the date due, Pro
Uro Care Inc. shall be in default of its obligations under this Agreement. 
If Pro Uro Care Inc. does not cure the default within twenty (20) days,
Plaintiff may enforce the judgment by confession as set forth in Paragraph 2
below, without further notice.  Once Pro Uro Care Inc. makes all
payments described in Paragraph 1 above, Plaintiff shall destroy the Confession
of Judgment.

     

    
      
        
        

      

      
        3

        
          

        

      

      
        
        

      

    

    2. Judgment
by Confession:  Pro Uro Care Inc. hereby agrees to execute an
Affidavit for Judgment by Confession in the principal amount of One Hundred
Seventeen Thousand Dollars ($117,000.00) in the form annexed hereto as Exhibit A.  Pro
Uro Care Inc. further agrees that if any payment provided for in Paragraph 1 is
not paid on or before the due date, and such default is not cured within twenty
(20) days of the failure to make such payment, Plaintiff shall be entitled to
record and enforce a Judgment by Confession to be obtained pursuant to the
Affidavit of Judgment by Confession, without further notice.  The judgment
obtained pursuant to the Affidavit of Judgment by Confession shall include
interest at the rate of Nine Percent (9%) per annum, calculated in accordance
with New York CPLR 5001 and 5004, from the date of default.  Plaintiff
shall be entitled to enforce said judgment by any lawful means.  Upon the
execution of this Agreement, Pro Uro Care Inc. shall execute the Affidavit for
Judgment by Confession in the form annexed hereto as Exhibit A. 
Plaintiff, or its counsel, shall retain the original executed Affidavit for
Judgment by Confession. 

     

    3. Release:  In
consideration of the Settlement Payment described in Paragraph 1 above, the
parties and their agents, officers, directors, parents, subsidiaries,
affiliates, attorneys, employees, predecessor companies, and successors in
interest hereby fully release and forever discharge one another and their
respective agents, officers, directors, parents, subsidiaries, affiliates,
agents, attorneys, employees, predecessor companies, and successors in interest
of and from all actions, causes of actions, suits, liability, debts, dues, sums
of money, covenants, contracts, controversies, agreements, damages, judgments
and demands whatsoever, in law, admiralty or equity, which against one another,
any of the parties ever had, now has, or may have, for, upon, or by reason of
any matter, cause or thing, whatsoever, including, but not limited to, all
claims or causes of action arising out of or in any way related to the matters
set forth in the other pleadings in the Action, from the beginning of the world
to the date of this release.

     

    
      
        
        

      

      
        4

        
          

        

      

      
        
        

      

    

    4. Stipulation
of Discontinuance:  The parties shall execute and file a stipulation
of discontinuance of this action.  Such stipulation of discontinuance shall
be with prejudice, but without costs, disbursements or fees against any
party. The stipulation
of discontinuance shall be filed by Plaintiff’s counsel upon receipt of this
executed Agreement along with the initial payment referenced in paragraph
1(A).   

     

    5. Correspondence: 
All correspondence related to this Agreement shall be mailed to the party to
whom it is directed at the address set forth below by first-class mail, or to
such other address as that party shall specify to the others in a notice given
in the manner set forth herein.

     

    
      	
              Plaintiff

            	
              Defendants

            
	 	 
	
              William
      S. Nolan, Esq.

            	
              Edward
      T. Matthews, Esq.

            
	
              Whiteman
      Osterman & Hanna LLP

            	
              Fredrikson
      & Byron, P.A.

            
	
              One
      Commerce Plaza

            	
              200
      South Sixth Street, Suite 4000

            
	
              Albany,
      New York 12260

            	
              Minneapolis,
      MN 55402

            

    

     

    

    6. Governing
Law:  This Agreement shall be governed by and construed for all
purposes under the laws of the State of New York without regard to choice of law
or conflict of laws rules.

     

    7. Binding
and Inure:  This Agreement shall apply to, be binding upon, and
inure to the benefit of the parties, their officers, directors, agents,
servants, employees, corporate affiliates and or subsidiaries, predecessors,
heirs, executors, administrators, successors and assigns.

     

    8. Entire
Agreement:  This Agreement constitutes the entire understanding
between the parties with respect to settlement of this action and supersedes and
replaces in all respects all prior agreements or understandings, whether formal
or informal, oral or in writing, among the parties or between any of them with
respect to the settlement of this Action.  This Agreement may only be
amended or terminated by a writing signed by all parties hereto.

     

    
      
        
        

      

      
        5

        
          

        

      

      
        
        

      

    

    9. No
Presumption Against Drafter:  The parties agree that neither party
takes responsibility for the drafting of this Agreement and the draftsman’s
presumption shall be held inapplicable in any action interpreting or enforcing
this Agreement.

     

    10. Authority
to Execute:  Each of the persons signing this Agreement hereby
represents and warrants that he or she has the authority to enter this Agreement
and bind the party on whose behalf he or she is signing.

     

    
      
        
        

      

      
        6

        
          

        

      

      
        
        

      

    

     

    

    

    

    
      	 	 	

              PRO URO CARE
      INC.

            
	 	 	 
	 	 	 
	 	 	 
	
               

            	 	
              

                By:
      /s/
      Richard C. Carlson

              

            
	 
      	 	
                               
      [NAME]

            
	 
      	 	 
      
	 
      	 	 
      
	 
      	 	 
      
	 
      	 	 
      
	
              STATE
      OF MINNESOTA

            	

              )

            	
               

            
	
               

            	

              )
      ss.:

            	 
      
	
              COUNTY
      OF HENNEPIN

            	

              )

            	
               

            

    

    

    

    On the
7th day of DECEMBER, 2009 before me personally came RICHARD CARLSON to me known,
being to me duly sworn, did depose and say that he is an officer of ProUroCare
Inc., the corporation described herein and which executed the above instrument;
and that he signed his name thereto with the authority to bind said
corporation.

    

    

    
      	 	
              /s/
      Shanna Unke

            
	 	
              Notary
      Public

            

    

    

    

    

    
      
        
        

      

      
        7

        
          

        

      

      
        
        

      

    

    
 

    
      
        	 	 	

                

                  PROUROCARE MEDICAL
      INC. 

                

              
	 	 	 
	 	 	 
	 	 	 
	
                 

              	 	
                

                  By:
      /s/
      Richard C. Carlson

                

              
	 
      	 	
                                 
      [NAME]

              
	 
      	 	 
      
	 
      	 	 
      
	 
      	 	 
      
	 
      	 	 
      
	
                STATE
      OF MINNESOTA

              	

                )

              	
                 

              
	
                 

              	

                )
      ss.:

              	 
      
	
                COUNTY
      OF HENNEPIN

              	

                )

              	
                 

              

      

      

    

    

    On the
7th day of DECEMBER, 2009 before me personally came RICHARD CARLSON to me known,
being to me duly sworn, did depose and say that he is an officer of ProUroCare
Medical Inc., the corporation described herein and which executed the above
instrument; and that he signed his name thereto with the authority to bind said
corporation.

     

     

    
      
        	 	
                /s/
      Shanna Unke

              
	 	
                Notary
      Public

              

      

      

      
        
          
          

        

        
          8

          
            

          

        

        
          
          

        

      

    

    

    

    
      
        
          	 	 	

                  

                    

                      RENSSELAER
      POLYTECHNIC INSTITUTE

                    

                  

                
	 	 	 
	 	 	 
	 	 	 
	
                   

                	 	
                  

                    By:
      /s/
      Charles F. Carletta

                  

                
	 
      	 	
                  Charles
      F. Carletta, Secretary of the Institute

                
	 
      	 	 
      
	 
      	 	 
      
	 
      	 	 
      
	 
      	 	 
      
	
                  

                    STATE
      OF NEW YORK

                  

                	

                  )

                	
                   

                
	
                   

                	

                  )
      ss.:

                	 
      
	
                  

                    COUNTY
      OF RENSSELAER

                  

                	

                  )

                	
                   

                

        

      

    

     

    

    On the
1st day of December, 2009 before me personally came Charles F. Carletta, to me
known, being to me duly sworn, did depose and say that he is  the
Secretary of Rensselaer Polytechnic Institute, the educational institution
described herein and which executed the above instrument; and that he signed his
name thereto with the authority to bind said educational
institution. 

     

    
       

      
        
          	 	
                  /s/
      Martin Ricciarddi

                
	 	
                  Notary
      Public

                

        

        
 

        
          
            
            

          

          
            9

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