Document:

Consulting Agreement

 Exhibit 10.277 
 CONSULTING AGREEMENT 
 This CONSULTING AGREEMENT (the
“Agreement”) is made this 4th day
of February, 2011, to be effective on May 19, 2011, by and between Pharmaceutical Product Development, Inc., a North Carolina corporation with its principal place of business in New Hanover County, North Carolina (the
“Company”), and David L. Grange, a citizen and resident of New Hanover County, North Carolina (“Consultant”). (Hereinafter, the Company and Consultant are sometimes referred to each as a
“Party” and together as the “Parties.”) 
 WHEREAS, Consultant has been employed
by the Company as its Chief Executive Officer; and 
 WHEREAS, Consultant has elected to retire from the Company, effective as
of May 18, 2011, and has entered into that certain Separation and Release Agreement of even date herewith with the Company (the “Separation Agreement”); 

WHEREAS, for a period of time following the termination of his employment with the Company, Consultant has agreed to provide certain
consulting services to the Company subject to the conditions of this Agreement; and 
 NOW, THEREFORE, in consideration of the
mutual promises and agreements set forth herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby expressly acknowledged, the Parties hereby agree as follows. 

1. Services. The services to be performed by Consultant under this Agreement are set forth on Exhibit A, attached
hereto, and are hereafter referred to as the “Services.” Consultant will not be expected to devote more than twenty (20) hours per week during normal business hours, Monday through Friday, in performing the Services.
Consultant agrees to perform the Services in a timely and professional manner and at the direction of the Company’s Board of Directors or Executive Chairman. 
 2. Consulting Term. The term of this Agreement will commence as of May 19, 2011 and shall continue through December 31, 2011, unless earlier terminated pursuant to Section 4 (the
“Consulting Term”). 
 3. Compensation. During the Consulting Term,
the Company will pay Consultant a monthly consulting fee in the amount of $50,000.00 per month (the “Monthly Consulting Fee”). During the Consulting Term, the Company will pay Consultant the Monthly Consulting Fee on or
before the tenth (10th) day of the month following
the month in which Consultant was obligated to provide the Services. For any month during the Consulting Term that is less than a full calendar month, the Monthly Consulting Fee will be prorated based on the number of days in such month for which
this Agreement was in effect as compared to the total number of days in such month. The Company further agrees to reimburse Consultant for all reasonable business expenses incurred by Consultant in connection with providing the Services, provided
that the Company has approved such business expenses in advance. 

 4. Termination. 

a. Termination for Cause. At any time prior to the end of the Consulting Term, the Company may terminate this Agreement
immediately and without advanced notice for “Cause.” For purposes of this Agreement, “Cause” shall mean and include: (i) Consultant’s material breach of this Agreement or any other agreement between
Consultant and the Company; (ii) Consultant’s commission of a felony or crime involving moral turpitude; (iii) any act by Consultant involving dishonesty in the performance of the Services, including, without limitation, fraud,
misappropriation or embezzlement; (iv) Consultant’s repeated failure or refusal to perform the Services; (v) any willful or grossly negligent act or omission by Consultant that is injurious to the Company, including injury to the
Company’s reputation; or (vi) Consultant’s revocation of the Separation Agreement. If the Company terminates this Agreement for Cause, the Company will pay Consultant only that portion of the Monthly Consulting Fee due to Consultant
for Services performed through the effective date of the termination and any pre-approved business expenses in accordance with Section 3, above. 
 b. Other Termination. This Agreement shall terminate immediately upon Consultant’s death or “Disability.” For purposes of this Agreement, “Disability” is
defined as Consultant’s inability to perform the Services for a period of thirty (30) consecutive days. If this Agreement is terminated due to Consultant’s death or Disability, the Company will pay Consultant only that portion of the
Monthly Consulting Fee due to Consultant for Services performed through the effective date of the termination and any pre-approved business expenses in accordance with Section 3, above. 

5. Independent Contractor Status. During the Consulting Term, Consultant will be an independent contractor and not the
Company’s employee for any purpose, including, but not limited to, the application of the Fair Labor Standards Act’s minimum wage and overtime provisions, the Federal Insurance Contribution Act, the Social Security Act, the Federal
Unemployment Tax Act, the provisions of the Internal Revenue Code, and all federal, state and local laws and regulations. Consultant understands that the Company will not be responsible for withholding or paying any federal or state income, social
security or other taxes in connection with any compensation paid under this Agreement, and Consultant agrees to pay all such taxes when due. The Company will provide Consultant with a Form 1099 to the extent required by law. Consultant hereby agrees
to indemnify and hold the Company harmless from any and all claims, causes of action or other proceedings related to or resulting from Consultant’s failure to pay taxes in compliance with applicable law. Consultant further understands and
agrees that Consultant will not be entitled to any medical, disability, pension or other employment benefits made available by the Company to its employees. During the Consulting Term, Consultant will retain sole and absolute discretion and judgment
in the manner and means of carrying out the Services. Consultant further agrees that during the Consulting Term, he has a full opportunity to find other business (so long as such other business is not in violation of this Agreement, the Separation
Agreement, the Non-Competition Agreement (as defined below) or the Proprietary Information Agreement (as defined below)), and that he will use a high level of skill necessary to perform the Services. During the Consulting Term, Consultant will not
have the authority to enter into any contract on behalf of the Company or otherwise to bind the Company to any agreement unless expressly authorized in writing to do so, and the Company will not be liable for

  
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any obligation incurred by Consultant during the Consulting Term, including, but not limited to, unpaid minimum wages and/or overtime premiums. During the Consulting Term, Consultant shall
indemnify and hold the Company harmless from all claims, losses, injuries or damages, and wages or any other form of compensation (including, without limitation, reasonable attorneys’ fees and costs) arising in connection with any claim, suit
or proceeding alleging that Consultant has or had a relationship with the Company other than an independent contracting relationship during the Consulting Term. 
 6. Prior Agreements. Consultant hereby acknowledges and agrees that his duties and obligations under the Proprietary Information and Inventions Agreement signed in connection with Consultant’s
employment with the Company (the “Proprietary Information Agreement”) and the Non-Competition and Non-Solicitation Agreement signed in connection with Consultant’s employment with the Company, as amended by the
Separation Agreement (the “Non-Competition Agreement”), are and will remain in full force and effect in accordance with their respective terms, and that a breach of either of those agreements will also constitute a breach of
this present Agreement. Consultant further acknowledges and agrees that the Proprietary Information Agreement shall apply to him during the Consulting Term as if he were employed by the Company during such Consulting Term. 

7. Company Property. By no later than the end of the Consulting Term, or at the earlier request of the Company’s Board of
Directors, Executive will return all personal property of the Company in his possession (the “Company Property”), including, without limitation, any Company-owned equipment, and all originals and any copies of all disks,
tapes, files, correspondence, notes and other documents pertaining to the Company’s proprietary products, customers and business and Proprietary Information as defined in Section 1 of the Proprietary Information Agreement. Such Company
Property will be in substantially the same condition as when provided to Executive, reasonable wear and tear excepted. 
 8.
No Conflicting Obligations. Consultant hereby represents that his agreement to the terms of this Agreement will not breach any agreement not to compete or solicit customers or employees or to keep in confidence any proprietary information
acquired by Consultant in confidence or in trust prior to the execution of this Agreement. Consultant further represents that he has not entered into, and agrees he will not enter into, any agreement, either written or oral, in conflict with this
Agreement. 
 9. Binding Effect; Waiver of Breach. Consultant acknowledges and agrees that his obligations under Sections
5, 6, 7 and 8 of this Agreement will survive the termination of this Agreement regardless of the cause or manner of the termination. Any waiver by the Company of a breach of any provision of this Agreement will not operate as a waiver of any
subsequent breach of that provision or any other provision of this Agreement. 
 10. Choice Of Law. This Agreement is to
be governed by the laws of the State of North Carolina without regard to its choice of law provisions, and any suit, action or charge arising out of or relating to this Agreement will be adjudicated in the state or federal courts in New Hanover
County, North Carolina. 

  
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 11. Complete and Final Agreement. This Agreement (including any exhibits, and
inclusive of the Proprietary Information Agreement and the Non-Competition Agreement) represents the complete and final agreement of the Parties and will control over any other statement, representation or agreement by the Company. This Agreement
supersedes any prior negotiations or discussions between the Parties with regard to the subject matter hereof. This Agreement may be amended only in a writing signed by each of the Parties hereto. 

13. Headings. The headings or titles to the paragraphs of this Agreement are solely for convenience of reference and shall be
ignored when interpreting this Agreement. 
 14. Severability and Construction. Should any part of this Agreement be
declared invalid for any reason by any court of competent jurisdiction, such decision or determination shall not affect the validity of any remaining portion, and such remaining portion shall remain in force and effect as if this Agreement had been
executed with the invalid portion eliminated; provided, that, in the event of a declaration of invalidity, the provision declared invalid shall not be invalidated in its entirety, but shall be observed and performed by the Parties to the extent such
provision is valid and enforceable. The Parties hereby agree that any such provision shall be deemed to be altered and amended to the extent necessary to effect such validity and enforceability. 

15. Voluntary Execution. Consultant hereby acknowledges that he has read the foregoing Agreement, that he understands its
contents, and that he has relied upon or had the opportunity to seek the legal advice of his attorney, who is the attorney of his choosing. 
 16. Counterparts. This Agreement may be executed in any number of counterparts and all of such counterparts shall for all purposes constitute one and the same instrument. 

17. Notices. All notices or demands by any Party relating to this Agreement shall be in writing and shall be deemed effectively
given: (a) upon person delivery to the Party to be notified; (b) three (3) days after having been sent by registered mail, postage prepaid, return receipt requested; or (c) one (1) day after deposit with a nationally
recognized overnight courier, specifying next day delivery, at its addresses set forth below: 
  

			
	If to the Company:	  	Pharmaceutical Product Development, Inc.
		  	929 Front Street
		  	Wilmington, NC 28401
		  	Attn: Executive Chairman
		
	If to Consultant:	  	David L. Grange
		  	8316 Bald Eagle Lane
		  	Wilmington, NC 28411

 The Parties hereto may change the
address at which they are to receive notice hereunder, by notice in writing in the foregoing manner given to the other. 

  
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 IN WITNESS WHEREOF, each of the Parties hereto acknowledges having read and understood the
contents and effect of this Agreement and has executed this Agreement freely and with full authority duly given, all as of the date first above written. 

 

					
	THE COMPANY:	 	 
	
	PHARMACEUTICAL PRODUCT DEVELOPMENT, INC.
			
	By:	 	 /s/ Fred Eshelman
	 	
	Name:	 	Fred Eshelman	 	
	Title:	 	Executive Chairman	 	
		
	CONSULTANT:	 	
		
	 /s/ David L. Grange
	 	(SEAL)
	David L. Grange	 	

  
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 EXHIBIT A 
 THE “SERVICES” DEFINED 
 The Services shall consist of: 

 

	1.	Assistance with the transition of his overall duties and responsibilities as the Company’s former Chief Executive Officer. 

 

	2.	Assistance with the transition of any projects or initiatives for which Consultant was responsible and which were active or on-going as of the date hereof.

  

	3.	Assistance with on-boarding the Company’s new Chief Executive Officer or other assistance in transitioning his duties to such person. 

 

	4.	Assistance with respect to any client programs, projects or relationships. 

 

	5.	Assistance with respect to any potential clients and relationships therewith. 

 

	6.	Assistance on other business development matters. 

  

	7.	Assistance in transitioning the supervision of his direct reports. 

  
 6Separation and Release Agreement

 Exhibit 10.278 
 SEPARATION AND RELEASE AGREEMENT 
 This SEPARATION AND
RELEASE AGREEMENT (the “Agreement”) is made this 4th day of February, 2011, by and between Pharmaceutical Product Development, Inc., a North Carolina corporation with its principal place of business in New Hanover County, North Carolina (the
“Company”), and David L. Grange, a citizen and resident of New Hanover County, North Carolina (“Executive”). (Hereinafter, the Company and Executive are sometimes referred to each as a
“Party” and together as the “Parties.”) 
 WHEREAS, Executive has been employed
by the Company as its Chief Executive Officer pursuant to an Employment Agreement dated May 19, 2009 (the “Employment Agreement”); and 
 WHEREAS, Executive has informed the Company that he wishes to retire, effective as of May 18, 2011; and 
 WHEREAS, the Parties wish to document the agreed terms of Executive’s separation from the Company through this Agreement; 
 NOW, THEREFORE, in consideration of the mutual promises and agreements set forth herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby expressly
acknowledged, the Parties hereby agree as follows: 
 1. Separation. Effective as of May 18, 2011 (the
“Termination Date”), Executive hereby retires/resigns from his position as Chief Executive Officer of the Company and as a member of the Company’s Board of Directors (the “Board”), as well as all
positions as an officer, director and employee of all Company subsidiaries. Executive will also not stand for re-election to the Board at the 2011 annual shareholders’ meeting. The Company will pay Executive for any accrued, unpaid base salary
and any accrued, unused paid time off through the Termination Date, on the Company’s next regular pay day after the Termination Date. Except as set out in this Agreement, as provided by the specific terms of a benefit plan or as required by
law, effective as of the Termination Date, all of Executive’s employee benefits with the Company will be terminated. Upon receipt of Executive’s final paycheck from the Company, Executive agrees and acknowledges that he will have been paid
all wages for labor or services rendered by him for the Company or on the Company’s behalf through the Termination Date, and that, other than as specifically provided in this Agreement, Executive is not entitled to any other severance or
termination pay or benefits. 
 2. Separation Benefits. In consideration of Executive’s signing and not revoking
this Agreement, the Company will provide Executive with the following “Separation Benefits”: 
 a. In
connection with his employment with the Company, the Company provided Executive with a sign-on bonus of $430,000 (the “Sign-On Bonus”) pursuant to a Sign-On Bonus Agreement dated May 19, 2009 (the “Sign-On
Bonus Agreement”). In accordance with the Sign-On Bonus Agreement, if Executive voluntarily terminated his employment less than 24 months from his employment date of July 1, 2009, Executive would be required to pay back a

 
percentage of the Sign-On Bonus. If Executive signs and does not revoke his acceptance of this Agreement, the Company will waive any and all right to repayment of the Sign-On Bonus by Executive.

 b. In connection with his employment with the Company, the Company paid on Executive’s behalf certain relocation
expenses in order to assist him in his move from Chicago, Illinois to Wilmington, North Carolina (the “Relocation Assistance”) pursuant to a Relocation Agreement dated May 19, 2009 (the “Relocation
Agreement”). In accordance with the Relocation Agreement, if Executive voluntarily terminated his employment less than 24 months from the date of his move, Executive would be required to pay back a percentage of the Relocation
Assistance. If Executive signs and does not revoke his acceptance of this Agreement, the Company will waive any and all right to repayment of the Relocation Assistance by Executive. 

c. The Company will pay on Executive’s behalf the costs of maintaining Executive’s group health insurance coverage should
Executive elect to continue his health insurance coverage through the Consolidated Omnibus Budget Reconciliation Act of 1986 (“COBRA”) until the earlier of (i) the expiration of Executive’s COBRA benefits or
(ii) the date on which Executive obtains health insurance coverage from another employer. Executive agrees to promptly notify the Company if Executive obtains health insurance coverage as contemplated under (ii) above. 

3. Consulting Agreement. Executive and the Company agree that in order to facilitate the transition of Executive’s duties and
responsibilities to a new Chief Executive Officer and otherwise ensure an orderly and smooth succession, the Parties will enter into a consulting arrangement pursuant to the terms of the Consulting Agreement that is attached hereto as Exhibit A (the
“Consulting Agreement”). The Parties agree that a breach of the Consulting Agreement shall also constitute a breach of this Agreement. 
 4. Equity. 
 a. Pursuant to the Company’s 1995 Equity Compensation
Plan, the Company has granted Executive nonqualified option to purchase shares of the Company’s common stock in connection with Executive’s service as a director on the Board and as its Chief Executive Officer. If Executive signs and does
not revoke this Agreement, Executive’s outstanding nonqualified stock options as of the Termination Date (the “Stock Options”) will continue to vest in accordance with their respective vesting schedules through
December 31, 2011, at which time any Stock Options not vested will expire immediately and automatically without any further action by the Parties or notice to Executive. Executive’s exercise period for any Stock Options vested and
outstanding as of December 31, 2011 will be extended to May 31, 2012. By signing this Agreement, Executive agrees and acknowledges that Executive is solely responsible for payment of all required taxes on the exercise of such Stock
Options. 
 b. Pursuant to the Employment Agreement, the Company’s 1995 Equity Compensation Plan and a Restricted Stock
Award Agreement dated July 1, 2009 between the Parties, the Company granted Executive a total of 50,000 shares of restricted stock (the 

  
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“Restricted Stock”). If Executive signs and does not revoke this Agreement, Executive’s Restricted Stock will continue to vest and be released from the restrictions
set forth in the Restricted Stock Award Agreement in accordance with the four year vesting schedule through December 31, 2011, at which time any Restricted Stock not vested will be forfeited immediately and automatically to the Company as of
December 31, 2011 without any further action by the Parties or notice to Executive. By signing this Agreement, Executive agrees and acknowledges that he is solely responsible for payment of all required taxes in connection with the
Company’s grant to him of the Restricted Stock. 
 Executive hereby acknowledges and agrees that if he does not sign
this Agreement and return it to the Company within twenty-one (21) days, or if he revokes his acceptance of this Agreement pursuant to Section 11 below, he will not be entitled to receive the Separation Benefits under Section 2, the
Consulting Agreement under Section 3, the benefits under this Section 4 or any other benefits under this Agreement. 
 5. Company Property. On or before the Termination Date, Executive will return all personal property of the Company in his possession (the “Company Property”), including,
without limitation, any Company-owned equipment, and all originals and any copies of all disks, tapes, files, correspondence, notes and other documents pertaining to the Company’s proprietary products, customers and business and Proprietary
Information as defined in Section 1 of the Proprietary Information and Inventions Agreement signed in connection with Executive’s employment with the Company (the “Proprietary Information Agreement”). Such Company
Property will be in substantially the same condition as when provided to Executive, reasonable wear and tear excepted. 
 6.
Release of Claims. In exchange for the Separation Benefits described in Section 2 and the additional vesting of Stock Options and Restricted Stock and the extension of the time to exercise vested Stock Options pursuant to Section 4,
and other good and valuable consideration, by signing this Agreement, Executive releases and forever discharges the Company, as well as any of its predecessors, successors and assigns and its past, present and future owners, parents, subsidiaries,
affiliates, predecessors, successors, assigns, officers, directors, stockholders, employees, employee benefit plans (together with all plan administrators, trustees, fiduciaries and insurers and agents the “Company Released
Parties”), from any and all claims, demands, and causes of action of every kind and nature, whether known or unknown, direct or indirect, accrued, contingent or potential, which Executive ever had or now has, including but not limited
to any claims arising out of or related to Executive’s employment with the Company and the termination thereof (except where and to the extent that such a release is expressly prohibited or made void by law). This release includes, without
limitation, Executive’s release of the Company and the Company Parties from any claims by him for lost wages or benefits, stock options, restricted stock, compensatory damages, punitive damages, attorneys’ fees and costs, equitable relief
or any other form of damages or relief. In addition, this release is meant to release the Company and the Company Parties from all common law claims, including claims in contract or tort, including, without limitation, claims for breach of contract,
wrongful or constructive discharge, shareholder derivative claims, intentional or negligent infliction of emotional distress, misrepresentation, tortious interference with contract or prospective economic advantage, invasion of privacy, defamation,
negligence or breach of any covenant of 

  
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good faith and fair dealing. Executive also specifically and forever releases the Company and the Company Parties (except where and to the extent that such a release is expressly prohibited or
made void by law) from any claims based on unlawful employment discrimination or harassment, including, but not limited to, the Federal Age Discrimination In Employment Act (29 U.S.C. § 621 et. seq.). 

Executive acknowledges that this release applies both to known and unknown claims that may exist between Executive and the Company and
the Company Parties. Executive expressly waives and relinquishes all rights and benefits which he may have under any state or federal statute or common law principle that would otherwise limit the effect of this Agreement to claims known or
suspected prior to the date Executive executes this Agreement, and does so understanding and acknowledging the significance and consequences of such specific waiver. By signing this Agreement, Executive acknowledges and agrees that he has no cause
to believe that any violation of any local, state or federal law has occurred with respect to his employment or separation of employment from the Company. Provided, however, that nothing in this Agreement extinguishes any claims Executive may have
against the Company for breach of this Agreement. 
 7. No Admissions. Executive understands, acknowledges and agrees
that the release set out above in Section 6 is a final compromise of any potential claims by Executive against the Company and/or the Company Parties in connection with Executive’s employment by the Company, and is not an admission by the
Company or the Company Parties that any such claims exist or that the Company or any of the Company Parties are liable for any such claims. Unless prohibited by applicable law or regulation, Executive further agrees not to hereafter, directly or
indirectly, sue, assist in or be a voluntary party to any litigation against Company or any one or more of the Company Parties for any claims relating to events occurring prior to or simultaneously with the execution of this Agreement, including but
not limited to Executive’s termination of employment with the Company. 
 Notwithstanding the foregoing, nothing in this
Agreement prohibits Executive from filing a charge with, or participating in any investigation or proceeding conducted by, the U.S. Equal Employment Opportunity Commission or a comparable state or federal fair employment practices agency; provided,
however, that this Agreement fully and finally resolves all monetary matters between Executive and the Company and the Company Parties, and by signing this Agreement, Executive is waiving any right to monetary damages, attorneys’ fees and/or
costs related to or arising from any such charge, complaint or lawsuit filed by Executive or on Executive’s behalf, individually or collectively. 
 8. Prior Agreements. 
 a. Executive hereby acknowledges and agrees that his
duties and obligations under the Proprietary Information Agreement and under the Non-Competition and Non-Solicitation Agreement signed in connection with Executive’s employment with the Company (the “Non-Competition
Agreement”) are in full force and effect in accordance with their respective terms. 

  
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 b. In exchange for the Separation Benefits described in Section 2 and the additional
vesting of Stock Options and Restricted Stock and the extension of the time to exercise vested Stock Options pursuant to Section 4, and other good and valuable consideration, the Parties hereby amend the Non-Competition Agreement as follows:

  

	 	i.	Section 1.1 is hereby deleted in its entirety. 

  

	 	ii.	Section 1.2 is hereby deleted in its entirety and replaced in full by the following: 

“1.2 Non-Solicitation of Customers. During Employee’s employment with PPD and through December 31, 2012, Employee
will not, directly or indirectly, (a) solicit the business of any person, firm, corporation, partnership, limited liability company, trust or other business entity which is a customer of PPD or which was a customer of PPD at any time during
Employee’s employment with PPD, (b) in any other manner persuade or attempt to persuade any such person, firm, corporation, partnership, limited liability company, trust or other business entity to discontinue or alter its business
relationship with PPD, or (c) otherwise solicit for a competitive purpose or interfere with PPD’s relationship with any such person, firm, corporation, partnership, limited liability company, trust or other business entity.”

  

	 	iii.	Section 1.3 is hereby deleted in its entirety and replaced in full by the following: 

“1.3 Non-Solicitation of Employees. During the Employee’s employment with PPD and through December 31, 2012,
Employee shall not, directly or indirectly, in any manner, (a) solicit, hire, or offer to hire any employee or contractor of PPD while that person is employed or engaged by PPD and for three (3) months after the termination of that
person’s employment or engagement with PPD, or (b) otherwise encourage or induce any such employee or contractor to discontinue his or her relationship with PPD.” 

c. The Parties agree that a breach of the Non-Competition Agreement or the Proprietary Information Agreement will also constitute a
breach of this Agreement. 
 9. No Disparagement. Each Party agrees that they will not denigrate, defame, disparage or
cast aspersions upon the other Party (and with respect to the Company, upon the Company Parties, their products, services, business and manner of doing business). 
 10. Relief and Enforcement. Executive also understands and agrees that if he violates the terms of Sections 5, 8 or 9 of this Agreement, he will cause injury to the Company and/or one or more of
the Company Parties) that will be difficult to quantify or repair, so that the Company (and/or the Company Parties) will have no adequate remedy at law. Accordingly, Executive 

  
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agrees that if he violates Sections 5, 8 or 9 of this Agreement, the Company (or the Company Parties) will be entitled as a matter of right to seek an injunction from a court of law, restraining
Executive from any further violation of this Agreement. The right to an injunction is in addition to, and not in lieu of, any other remedies that the Company (or the Company Parties) has at law or in equity. 

11. Right to Revoke. ONCE SIGNED BY EXECUTIVE, THIS AGREEMENT IS REVOCABLE IN WRITING FOR A PERIOD OF SEVEN (7) DAYS (THE
“REVOCATION PERIOD”). IN ORDER TO REVOKE HIS ACCEPTANCE OF THIS AGREEMENT, EXECUTIVE MUST DELIVER WRITTEN NOTICE OF REVOCATION TO JUDD HARTMAN, AND SUCH WRITTEN NOTICE MUST ACTUALLY BE RECEIVED BY HIM WITHIN THE SEVEN
(7) DAY REVOCATION PERIOD. 
 12. No Modifications; Governing Law; Entire Agreement. This Agreement cannot be
changed or terminated verbally, and no modification or waiver of any of the provisions of this Agreement will be effective unless it is in writing and signed by both Parties. The Parties agree that this Agreement is to be governed by and construed
in accordance with the laws of the State of North Carolina, and that any suit, action or charge arising out of or relating to this Agreement will be adjudicated in the state or federal courts in New Hanover County, North Carolina. This Agreement
(including any exhibits, and inclusive of the Proprietary Information Agreement and the Non-Competition Agreement) sets forth the entire and fully integrated understanding between the Parties, and there are no representations, warranties, covenants
or understandings, oral or otherwise, that are not expressly set out herein. 
 13. Voluntary Execution. By signing
below, Executive acknowledges that he has read this Agreement, that he understands its contents and that he has relied upon or had the opportunity to seek the legal advice of his attorney, who is the attorney of his own choosing. 

14. Miscellaneous. 
 (a) Should any portion, term or provision of this Agreement be declared or determined by any court to be illegal, invalid or unenforceable, the validity or the remaining portions, terms and provisions
shall not be affected thereby, and the illegal, invalid or unenforceable portion, term or provision shall be deemed not to be part of this Agreement. 
 (b) The Parties agree that the failure of a Party at any time to require performance of any provision of this Agreement shall not affect, diminish, obviate or void in any way the Party’s full right
or ability to require performance of the same or any other provision of this Agreement at any time thereafter. 
 (c) This
Agreement shall inure to the benefit of and shall be binding upon Executive, his heirs, administrators, representatives, executors, successors and assigns and upon the successors and assigns of the Company. 

  
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 (d) The headings of the paragraphs of this Agreement are for convenience only and are not
binding on any interpretation of this Agreement. This Agreement may be executed in counterparts. 
 EXECUTIVE HEREBY ACKNOWLEDGES THAT HE HAS
BEEN GIVEN A PERIOD OF AT LEAST TWENTY-ONE (21) DAYS TO CONSIDER WHETHER TO EXECUTE THIS AGREEMENT. EXECUTIVE ALSO ACKNOWLEDGES THAT HE WAS ADVISED BY THE COMPANY IN WRITING TO CONSULT WITH AN ATTORNEY BEFORE SIGNING THIS AGREEMENT.

 IN WITNESS WHEREOF, each of the Parties hereto acknowledges having read and understood the contents and effect of this
Agreement and has executed this Separation and Release Agreement freely and with full authority duly given, all as of the date first above written. 
  

					
	THE COMPANY:
	
	PHARMACEUTICAL PRODUCT DEVELOPMENT, INC.
		
	By:	 	 /s/ Fred
Eshelman

					
	Name:	 	 Fred
Eshelman

					
	Title:	 	 Executive
Chairman

					
	
	Date:  February 4, 2011
	
	EXECUTIVE:
		
	 /s/ David L. Grange
	 	(SEAL)
	David L. Grange
	
	Date:  February 4, 2011

  
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