Document:

exv10w1

Exhibit 10.1

EXECUTION VERSION

COMMON STOCK PURCHASE AGREEMENT

by and between

KINGSBRIDGE CAPITAL LIMITED

and

EPIX PHARMACEUTICALS, INC.

dated as of August 4, 2008

 

 

TABLE OF CONTENTS

	 	 	 	 	 
	ARTICLE I DEFINITIONS
	 	 	1	 
	 
	 	 	 	 
	ARTICLE II PURCHASE AND SALE OF COMMON STOCK
	 	 	5	 
	Section 2.1 Purchase and Sale of Stock
	 	 	5	 
	Section 2.2 Closing
	 	 	5	 
	Section 2.3 Registration Statement and Prospectus
	 	 	6	 
	Section 2.4 Warrant
	 	 	6	 
	Section 2.5 Blackout Shares
	 	 	6	 
	 
	 	 	 	 
	ARTICLE III DRAW DOWN TERMS
	 	 	6	 
	Section 3.1 Draw Down Notice
	 	 	6	 
	Section 3.2 Number of Shares
	 	 	6	 
	Section 3.3 Limitation on Draw Downs
	 	 	6	 
	Section 3.4 Trading Cushion
	 	 	7	 
	Section 3.5 Settlement
	 	 	7	 
	Section 3.6 Delivery of Shares; Payment of Draw Down Amount
	 	 	7	 
	Section 3.7 Failure to Deliver Shares
	 	 	7	 
	 
	 	 	 	 
	ARTICLE IV REPRESENTATIONS AND WARRANTIES OF THE COMPANY
	 	 	8	 
	Section 4.1 Organization, Good Standing and Power
	 	 	8	 
	Section 4.2 Authorization; Enforcement
	 	 	9	 
	Section 4.3 Capitalization
	 	 	9	 
	Section 4.4 Issuance of Shares
	 	 	10	 
	Section 4.5 No Conflicts
	 	 	10	 
	Section 4.6 Commission Documents, Financial Statements
	 	 	11	 
	Section 4.7 No Material Adverse Change
	 	 	12	 
	Section 4.8 No Undisclosed Liabilities
	 	 	12	 
	Section 4.9 No Undisclosed Events or Circumstances
	 	 	12	 
	Section 4.10 Actions Pending
	 	 	12	 
	Section 4.11 Compliance with Law
	 	 	12	 
	Section 4.12 Certain Fees
	 	 	13	 
	Section 4.13 Disclosure
	 	 	13	 
	Section 4.14 Material Non-Public Information
	 	 	13	 
	Section 4.15 Exemption from Registration; Valid Issuances
	 	 	13	 
	Section 4.16 Form S-3 Eligibility
	 	 	13	 
	Section 4.17 No General Solicitation or Advertising in Regard to this Transaction
	 	 	13	 
	Section 4.18 No Integrated Offering
	 	 	14	 
	Section 4.19 Acknowledgment Regarding Investor’s Purchase of Shares
	 	 	14	 
	 
	 	 	 	 
	ARTICLE V REPRESENTATIONS, WARRANTIES AND COVENANTS OF THE INVESTOR
	 	 	14	 
	Section 5.1 Organization and Standing of the Investor
	 	 	14	 

 

 

	 	 	 	 	 
	Section 5.2 Authorization and Power
	 	 	14	 
	Section 5.3 No Conflicts
	 	 	14	 
	Section 5.4 Financial Capability
	 	 	15	 
	Section 5.5 Information
	 	 	15	 
	Section 5.6 Trading Restrictions
	 	 	15	 
	Section 5.7 Statutory Underwriter Status
	 	 	16	 
	Section 5.8 Not an Affiliate
	 	 	16	 
	Section 5.9 Manner of Sale
	 	 	16	 
	Section 5.10 Prospectus Delivery
	 	 	16	 
	 
	 	 	 	 
	ARTICLE VI COVENANTS OF THE COMPANY
	 	 	16	 
	Section 6.1 Securities Compliance
	 	 	16	 
	Section 6.2 Reservation of Common Stock
	 	 	16	 
	Section 6.3 Registration and Listing
	 	 	17	 
	Section 6.4 Registration Statement
	 	 	17	 
	Section 6.5 Compliance with Laws
	 	 	17	 
	Section 6.6 Other Financing
	 	 	18	 
	Section 6.7 Prohibited Transactions
	 	 	18	 
	Section 6.8 Corporate Existence
	 	 	18	 
	Section 6.9 Non-Disclosure of Non-Public Information
	 	 	19	 
	Section 6.10 Notice of Certain Events Affecting Registration; Suspension of Right to Request a Draw Down
	 	 	19	 
	Section 6.11 Amendments to the Registration Statement
	 	 	19	 
	Section 6.12 Prospectus Delivery
	 	 	20	 
	 
	 	 	 	 
	ARTICLE VII CONDITIONS TO THE OBLIGATION OF THE INVESTOR TO ACCEPT A DRAW DOWN
	 	 	20	 
	Section 7.1 Accuracy of the Company’s Representations and Warranties
	 	 	20	 
	Section 7.2 Performance by the Company
	 	 	20	 
	Section 7.3 Compliance with Law
	 	 	20	 
	Section 7.4 Effective Registration Statement
	 	 	20	 
	Section 7.5 No Knowledge
	 	 	21	 
	Section 7.6 No Suspension
	 	 	21	 
	Section 7.7 No Injunction
	 	 	21	 
	Section 7.8 No Proceedings or Litigation
	 	 	21	 
	Section 7.9 Sufficient Shares Registered for Resale
	 	 	21	 
	Section 7.10 Warrant
	 	 	21	 
	Section 7.11 Opinion of Counsel
	 	 	21	 
	Section 7.12 Accuracy of Investor’s Representation and Warranties
	 	 	22	 
	 
	 	 	 	 
	ARTICLE VIII TERMINATION
	 	 	22	 
	Section 8.1 Term
	 	 	22	 
	Section 8.2 Other Termination
	 	 	22	 
	Section 8.3 Effect of Termination
	 	 	22	 
	 
	 	 	 	 
	ARTICLE IX INDEMNIFICATION
	 	 	23	 
	Section 9.1 Indemnification
	 	 	23	 

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	Section 9.2 Notification of Claims for Indemnification
	 	 	24	 
	 
	 	 	 	 
	ARTICLE X MISCELLANEOUS
	 	 	25	 
	Section 10.1 Fees and Expenses
	 	 	25	 
	Section 10.2 Reporting Entity for the Common Stock
	 	 	26	 
	Section 10.3 Brokerage
	 	 	26	 
	Section 10.4 Notices
	 	 	27	 
	Section 10.5 Assignment
	 	 	28	 
	Section 10.6 Amendment; No Waiver
	 	 	28	 
	Section 10.7 Entire Agreement
	 	 	28	 
	Section 10.8 Severability
	 	 	28	 
	Section 10.9 Title and Subtitles
	 	 	29	 
	Section 10.10 Counterparts
	 	 	29	 
	Section 10.11 Choice of Law
	 	 	29	 
	Section 10.12 Specific Enforcement, Consent to Jurisdiction
	 	 	29	 
	Section 10.13 Survival
	 	 	29	 
	Section 10.14 Publicity
	 	 	30	 
	Section 10.15 Further Assurances
	 	 	30	 

- iii - 

 

     This COMMON STOCK PURCHASE AGREEMENT (this “Agreement”) is entered into as of the 4th
day of August, 2008, by and between Kingsbridge Capital Limited, an entity organized and existing
under the laws of the British Virgin Islands, whose registered address is P.O. Box 1075, Elizabeth
House, 9 Castle Street, St. Helier, Jersey JE42QP, Channel Islands (the “Investor”), and
EPIX Pharmaceuticals, Inc., a corporation organized and existing under the laws of the State of
Delaware (the “Company”).

     WHEREAS, the parties desire that, upon the terms and subject to the conditions and limitations
set forth herein, the Company may issue and sell to the Investor, from time to time as provided
herein, and the Investor shall purchase from the Company, up to $50 million worth of shares of
Common Stock (as defined below); and

     WHEREAS, such investments will be made in reliance upon the provisions of Section 4(2)
(“Section 4(2)”) and Regulation D (“Regulation D”) of the United States Securities
Act of 1933, as amended and the rules and regulations promulgated thereunder (the “Securities
Act”), and/or upon such other exemption from the registration requirements of the Securities
Act as may be available with respect to any or all of the investments in Common Stock to be made
hereunder; and

     WHEREAS, the parties hereto are concurrently entering into a Registration Rights Agreement in
the form of Exhibit A hereto (the “Registration Rights Agreement”) pursuant to
which the Company shall register the Common Stock issued and sold to the Investor under this
Agreement and issuable under the Warrant (as defined below), upon the terms and subject to the
conditions set forth therein; and

     WHEREAS, in consideration for the Investor’s execution and delivery of, and its performance of
its obligations under, this Agreement, the Company is concurrently issuing to the Investor a
Warrant in the form of Exhibit B hereto (the “Warrant”) pursuant to which the
Investor may purchase from the Company up to 400,000 shares of Common Stock, upon the terms and
subject to the conditions set forth therein;

     NOW, THEREFORE, the parties hereto agree as follows:

ARTICLE I

DEFINITIONS

     As used in this Agreement, the following terms shall have the meanings set forth below:

     “Alternative Draw Down Amount” means the product of (i) Average Trading Volume, (ii)
the Closing Price on the Trading Day preceding the issuance of the Draw Down Notice, (iii) eight
(8), and (iv) the Liquidity Ratio.

     “Average Trading Volume” means the average trading volume of the twenty (20) Trading
Days during the thirty (30) Trading Days prior to the issuance of the Draw Down Notice that results
from excluding the five (5) highest and five (5) lowest Trading Days during such period.

     “Blackout Amount” shall have the meaning assigned to such term in the Registration
Rights Agreement.

 

 

     “Blackout Shares” shall have the meaning assigned to such term in the Registration
Rights Agreement.

     “Bylaws” shall have the meaning assigned to such term in Section 4.3 hereof.

     “Charter” shall have the meaning assigned to such term in Section 4.3 hereof.

     “Closing Date” shall have the meaning assigned to such term in Section 2.2 hereof.

     “Closing Price” as of any particular day shall mean the closing price per share of the
Common Stock as reported by Bloomberg L.P. on such day.

     “Commission” means the United States Securities and Exchange Commission.

     “Commission Documents” shall have the meaning assigned to such term in Section 4.6
hereof.

     “Commitment Period” means the period commencing on the Effective Date and expiring on
the earliest to occur of (i) the date on which the Investor shall have purchased Shares pursuant to
this Agreement for an aggregate purchase price equal to the Maximum Commitment Amount, (ii) the
date this Agreement is terminated pursuant to Article VIII hereof, and (iii) the date occurring
thirty-six (36) months from the Effective Date.

     “Common Stock” means the common stock of the Company, par value $0.01 per share.

     “Condition Satisfaction Date” shall have the meaning assigned to such term in Article
VII hereof.

     “Damages” means any loss, claim, damage, liability, costs and expenses (including,
without limitation, reasonable attorneys’ fees and expenses and costs and reasonable expenses of
expert witnesses and investigation).

     “Draw Down” shall have the meaning assigned to such term in Section 3.1 hereof.

     “Draw Down Amount” means the actual dollar amount of a Draw Down paid to the Company.

     “Draw Down Discount Price” means (i) 88% of the VWAP on any Trading Day during a Draw
Down Pricing Period when the VWAP equals or exceeds $1.25 but is less than or equal to $1.90,
(ii) 90% of the VWAP on any Trading Day during the Draw Down Pricing Period when VWAP exceeds $1.90
but is less than or equal to $5.00, (iii) 92% of the VWAP on any Trading Day during the Draw Down
Pricing Period when VWAP exceeds $5.00 but is less than or equal to $10.00, or (iv) 94% of the VWAP
on any Trading Day during the Draw Down Pricing Period when VWAP exceeds $10.00.

     “Draw Down Notice” shall have the meaning assigned to such term in Section 3.1 hereof.

- 2 -

 

     “Draw Down Pricing Period” shall mean, with respect to each Draw Down, a period of
eight (8) consecutive Trading Days beginning on the first Trading Day specified in a Draw Down
Notice.

     “DTC” shall mean the Depository Trust Company, or any successor thereto.

     “Effective Date” means the first Trading Day immediately following the date on which
the Registration Statement is declared effective by the Commission.

     “Exchange Act” means the United States Securities Exchange Act of 1934, as amended,
and the rules and regulations promulgated thereunder.

     “Excluded Merger or Sale” shall have the meaning assigned to such term in the Warrant.

     “FINRA” means the Financial Industry Regulatory Authority.

     “Knowledge” means the actual knowledge of the Company’s Chief Executive Officer and
Chief Financial Officer.

     “Liquidity Ratio” means forty percent (40%).

     “Make Whole Amount” shall have the meaning specified in Section 3.7.

     “Market Capitalization” means, as of any Trading Day, the product of (i) the closing
sale price of the Company’s Common Stock as reported by Bloomberg L.P. using the AQR function and
(ii) the number of outstanding shares of Common Stock of the Company as reported by Bloomberg L.P.
using the DES function.

     “Material Adverse Effect” means any effect that is not negated, corrected, cured or
otherwise remedied within a reasonable period of time on the business, operations, properties or
financial condition of the Company and its consolidated subsidiaries that is material and adverse
to the Company and such subsidiaries, taken as a whole, and/or any condition, circumstance, or
situation that would prohibit or otherwise interfere with the ability of the Company to perform any
of its obligations under this Agreement, the Registration Rights Agreement or the Warrant in any
material respect; provided, however, that none of the following shall constitute a “Material
Adverse Effect”: (i) the effects of conditions or events that are generally applicable to the
capital, financial, banking or currency markets or the biotechnology or pharmaceutical industries;
(ii) the effects of conditions or events that are reasonably expected to occur in the Company’s
ordinary course of business (such as, by way of example only, failed clinical trials, serious
adverse events involving the Company’s product candidates or products, delays in product
development or commercial launch, unfavorable regulatory determinations, difficulties in generating
product sales or involving collaborators or intellectual property disputes), except for purposes of
Section 4.9 herein; (iii) any changes or effects resulting from the announcement or consummation of
the transactions contemplated by this Agreement, including, without limitation, any changes or
effects associated with any particular Draw Down, and (iv) changes in the market price of the
Common Stock.

- 3 -

 

     “Maximum Commitment Amount” means the lesser of (i) $50 million in aggregate Draw Down
Amounts or (ii) 8,280,120 shares of Common Stock (as adjusted for stock splits, stock combinations,
stock dividends and recapitalizations that occur on or after the date of this Agreement) minus the
number of Blackout Shares, if any, delivered to the Investor under the Registration Rights
Agreement; provided, however, that the Maximum Commitment Amount shall not exceed that number of
shares of Common Stock that the Company may issue pursuant to this Agreement and the transactions
contemplated hereby without breaching the Company’s obligations under the rules and regulations of
the Principal Market.

     “Maximum Draw Down Amount” means, at the Company’s option, the greater of (i) a
maximum of 1.5% of the Company’s Market Capitalization at the time of the Draw Down, or (ii) the
lesser of (A) 3% of the Company’s Market Capitalization at the time of the Draw Down, or (B) the
Alternative Draw Down Amount; provided, however, that in no event may the Maximum Draw Down Amount
exceed $10 million.

     “Permitted Transaction” shall have the meaning assigned to such term in Section 6.6
hereof.

     “Person” means any individual, corporation, partnership, limited liability company,
association, trust or other entity or organization, including any government or political
subdivision or an agency or instrumentality thereof.

     “Principal Market” means the NASDAQ Capital Market, the NASDAQ Global Select Market,
the NASDAQ Global Market, the American Stock Exchange or the New York Stock Exchange, whichever is
at the time the principal trading exchange or market for the Common Stock.

     “Prohibited Transaction” shall have the meaning assigned to such term in Section 6.7
hereof.

     “Prospectus” as used in this Agreement means the prospectus in the form included in
the Registration Statement, as supplemented from time to time pursuant to Rule 424(b) of the
Securities Act.

     “Registrable Securities” means (i) the Shares, (ii) the Warrant Shares, and (iii) any
securities issued or issuable with respect to any of the foregoing by way of exchange, stock
dividend or stock split or in connection with a combination of shares, recapitalization, merger,
consolidation or other reorganization or otherwise. As to any particular Registrable Securities,
once issued such securities shall cease to be Registrable Securities when (w) the Registration
Statement has been declared effective by the Commission and such Registrable Securities have been
disposed of pursuant to the Registration Statement, (x) such Registrable Securities have been sold
under circumstances under which all of the applicable conditions of Rule 144 (or any similar
provision then in force) under the Securities Act (“Rule 144”) are met, (y) such time as
such Registrable Securities have been otherwise transferred to holders who may trade such shares
without restriction under the Securities Act, and the Company has delivered a new certificate or
other evidence of ownership for such securities not bearing a restrictive legend or (z) in the
opinion of counsel to the Investor such Registrable Securities may be sold without

- 4 -

 

registration and without any time, volume or manner limitations pursuant to Rule 144 (or any
similar provision then in effect) under the Securities Act.

     “Registration Rights Agreement” shall have the meaning set forth in the recitals of
this Agreement.

     “Registration Statement” shall have the meaning assigned to such term in the
Registration Rights Agreement.

     “Regulation D” shall have the meaning set forth in the recitals of this Agreement.
“Section 4(2)” shall have the meaning set forth in the recitals of this Agreement.

     “Securities Act” shall have the meaning set forth in the recitals of this Agreement.

     “Settlement Date” shall have the meaning assigned to such term in Section 3.5 hereof.

     “Shares” means the shares of Common Stock of the Company that are and/or may be
purchased hereunder.

     “Trading Day” means any day other than a Saturday or a Sunday on which the Principal
Market is open for trading in equity securities.

     “VWAP” means the volume weighted average price (the aggregate sales price of all
trades of Common Stock during each Trading Day divided by the total number of shares of Common
Stock traded during such Trading Day) of the Common Stock during any Trading Day as reported by
Bloomberg, L.P. using the AQR function.

     “Warrant” shall have the meaning set forth in the recitals of this Agreement.

     “Warrant Shares” means the shares of Common Stock issuable to the Investor upon
exercise of the Warrant.

ARTICLE II

PURCHASE AND SALE OF COMMON STOCK

     Section 2.1 Purchase and Sale of Stock. Upon the terms and subject to the conditions
set forth in this Agreement, the Company shall to the extent it elects to make Draw Downs in
accordance with Article III hereof, issue and sell to the Investor and the Investor shall purchase
Common Stock from the Company for an aggregate (in Draw Down Amounts) of up to the Maximum
Commitment Amount, consisting of purchases based on Draw Downs in accordance with Article III
hereof.

     Section 2.2 Closing. In consideration of and in express reliance upon the
representations, warranties, covenants, terms and conditions of this Agreement, the Company agrees
to issue and sell to the Investor, and the Investor agrees to purchase from the Company, that
number of the Shares to be issued in connection with each Draw Down. The execution and delivery of
this Agreement (the “Closing”) shall take place at the offices of Stroock & Stroock & Lavan
LLP, 180 Maiden Lane, New York, NY 10038 at 5:00 p.m. local time on August 4, 2008,

- 5 -

 

or at such other time and place or on such date as the Investor and the Company may agree upon
(the “Closing Date”). Each party shall deliver at or prior to the Closing all documents,
instruments and writings required to be delivered at the Closing by such party pursuant to this
Agreement.

     Section 2.3 Registration Statement and Prospectus. The Company shall prepare and file
with the Commission the Registration Statement (including the Prospectus) in accordance with the
provisions of the Securities Act and the Registration Rights Agreement.

     Section 2.4 Warrant. On the Closing Date, the Company shall issue and deliver the
Warrant to the Investor.

     Section 2.5 Blackout Shares. The Company shall deliver any Blackout Amount or issue
and deliver any Blackout Shares to the Investor in accordance with Section 1.1(e) of the
Registration Rights Agreement.

ARTICLE III

DRAW DOWN TERMS

     Subject to the satisfaction of the conditions hereinafter set forth in this Agreement, the
parties agree as follows:

     Section 3.1 Draw Down Notice. During the Commitment Period, the Company may, in its
sole discretion, issue a Draw Down Notice (as hereinafter defined) which shall specify the dollar
amount of Shares the Company elects to sell to the Investor (each such election, a “Draw
Down”) up to a Draw Down Amount equal to the Maximum Draw Down Amount, which Draw Down the
Investor shall be obligated to accept. The Company shall inform the Investor in writing by sending
a duly completed Draw Down Notice (as hereinafter defined) in the form of Exhibit C hereto
by e-mail to the addresses set forth in Section 10.4, with a copy to the Investor’s counsel, as to
such Draw Down Amount before commencement of trading on the first Trading Day of the related Draw
Down Pricing Period (the “Draw Down Notice”). In addition to the Draw Down Amount, each
Draw Down Notice shall designate the first Trading Day of the Draw Down Pricing Period. In no
event shall any Draw Down Amount exceed the Maximum Draw Down Amount. Each Draw Down Notice shall
be accompanied by a certificate, signed by the Chief Executive Officer, Chief Financial Officer,
dated as of the date of such Draw Down Notice, in the form of Exhibit D hereof.

     Section 3.2 Number of Shares. Subject to Section 3.6(b), the number of Shares to be
issued in connection with each Draw Down shall be equal to the sum of the number of shares issuable
on each Trading Day of the Draw Down Pricing Period. Subject to Section 3.6(b), the number of
shares issuable on a Trading Day during a Draw Down Pricing Period shall be equal to the quotient
of one eighth (1/8th) of the Draw Down Amount divided by the Draw Down Discount Price for such
Trading Day.

     Section 3.3 Limitation on Draw Downs. Only one Draw Down shall be permitted for each
Draw Down Pricing Period.

- 6 -

 

     Section 3.4 Trading Cushion. Unless the parties agree in writing otherwise, there
shall be a minimum of three (3) Trading Days between the expiration of any Draw Down Pricing Period
and the beginning of the next succeeding Draw Down Pricing Period.

     Section 3.5 Settlement. The number of Shares purchased by the Investor in any Draw
Down shall be determined and settled on two separate dates. Shares purchased by the Investor
during the first four Trading Days of any Draw Down Pricing Period shall be determined and settled
no later than the sixth Trading Day of such Draw Down Pricing Period. Shares purchased by the
Investor during the second four Trading Days of any Draw Down Pricing Period shall be determined
and settled no later than the second Trading Day after the last Trading Day of such Draw Down
Pricing Period. Each date on which settlement of the purchase and sale of Shares occurs hereunder
being referred to as a “Settlement Date.” The Investor shall provide the Company with
delivery instructions for the Shares to be issued at each Settlement Date at least two Trading Days
in advance of such Settlement Date. The number of Shares actually issued shall be rounded to the
nearest whole number of Shares.

     Section 3.6 Delivery of Shares; Payment of Draw Down Amount.

          (a) On each Settlement Date, the Company shall deliver the Shares purchased by the Investor to
the Investor or its designees exclusively via book-entry through the DTC to an account designated
by the Investor, and upon receipt of the Shares, the Investor shall cause payment thereof to be
made to the Company’s designated account by wire transfer of immediately available funds, if the
Shares are received by the Investor no later than 1:00 p.m. (Eastern Time), or next day available
funds, if the Shares are received thereafter. Upon the written request of the Company, the
Investor will cause its banker to confirm to the Company that the Investor has provided irrevocable
instructions to cause payment for the Shares to be made as set forth above, upon confirmation by
such banker that the Shares have been delivered through the DTC in unrestricted form.

          (b) For each Trading Day during a Draw Down Pricing Period on which the VWAP is less than the
greater of (i) 90% of the Closing Price of the Company’s Common Stock on the Trading Day
immediately preceding the commencement of such Draw Down Pricing Period, or (ii) $1.25, such
Trading Day shall not be used in calculating the number of Shares to be issued in connection with
such Draw Down, and the Draw Down Amount in respect of such Draw Down Pricing Period shall be
reduced by one eighth (1/8th) of the initial Draw Down Amount specified in the Draw Down Notice.
If trading in the Company’s Common Stock is suspended for any reason for more than three (3)
consecutive or non-consecutive hours during any Trading Day during a Draw Down Pricing Period, such
Trading Day shall not be used in calculating the number of Shares to be issued in connection with
such Draw Down, and the Draw Down Amount in respect of such Draw Down Pricing Period shall be
reduced by one eighth (1/8th) of the initial Draw Down Amount specified in the Draw Down Notice.

     Section 3.7 Failure to Deliver Shares. If on any Settlement Date, the Company fails
to take all actions within the reasonable control of the Company to cause the delivery of the
Shares purchased by the Investor, and such failure is not cured within two (2) Trading Days
following such Settlement Date, the Company shall pay to the Investor on demand in cash by wire
transfer of immediately available funds to an account designated by the Investor the “Make
Whole 

- 7 -

 

Amount;” provided, however, that in the event that the Company is prevented from
delivering Shares in respect of any such Settlement Date in a timely manner by any fact or
circumstance that is not reasonably within the control of, or directly attributable to, the
Company, or is otherwise reasonably within the control of, or directly attributable to, the
Investor, then such two (2) Trading Day period shall be automatically extended until such time as
such fact or circumstance is cured. As used herein, the Make Whole Amount shall be an amount equal
to the sum of (i) the Draw Down Amount actually paid by the Investor in respect of such Shares plus
(ii) an amount equal to the actual loss suffered by the Investor in respect of sales to subsequent
purchasers, pursuant to transactions entered into before the Settlement Date, of the Shares that
were required to be delivered by the Company, which shall be based upon documentation reasonably
satisfactory to the Company demonstrating the difference (if greater than zero) between (A) the
price per share paid by the Investor to purchase such number of shares of Common Stock necessary
for the Investor to meet its share delivery obligations to such subsequent purchasers minus (B) the
average Draw Down Discount Price during the applicable Draw Down Pricing Period. In the event that
the Make Whole Amount is not paid within two (2) Trading Days following a demand therefor from the
Investor, the Make Whole Amount shall accrue interest compounded daily at a rate equal to the
greater of (i) the prime rate of interest then in effect as published by the Wall Street Journal
plus three percent (3%) and (ii) ten percent (10%), up to and including the date on which the Make
Whole Amount is actually paid. For the purposes of this Section 3.7, facts or circumstances that
are reasonably within the control of the Company include such facts and circumstances solely
attributable to acts or omissions of the Company, its officers, directors, employees, agents and
representatives, including, without limitation, any transfer agent(s), accountant(s) and/or
attorney(s) engaged by the Company in connection with the Company’s performance of its obligations
hereunder. Notwithstanding anything to the contrary set forth in this Agreement, in the event that
the Company pays the Make Whole Amount (plus interest, if applicable) in respect of any Settlement
Date in accordance with this Section 3.7, such payment shall be the Investor’s sole remedy in
respect of the Company’s failure to deliver Shares in respect of such Settlement Date, and the
Company shall not be obligated to deliver such Shares.

ARTICLE IV

REPRESENTATIONS AND WARRANTIES OF THE COMPANY

     The Company hereby makes the following representations and warranties to the Investor:

     Section 4.1 Organization, Good Standing and Power. The Company is a corporation duly
organized, validly existing and in good standing under the laws of the State of Delaware and has
all requisite corporate power and authority to own, lease and operate its properties and assets and
to carry on its business as now being conducted. Except as set forth in the Commission Documents
(as defined below), as of the date hereof, the Company does not own more than fifty percent (50%)
of the outstanding capital stock of or control any other business entity, other than any
wholly-owned subsidiary that is not “significant” within the meaning of Regulation S-X
promulgated by the Commission. The Company is duly qualified as a foreign corporation to do
business and is in good standing in every jurisdiction in which the nature of the business
conducted or property owned by it makes such qualification necessary, other than those in which the
failure to be so qualified or be in good standing would not have a Material Adverse Effect.

- 8 -

 

     Section 4.2 Authorization; Enforcement. (i) The Company has the requisite corporate
power and authority to enter into and perform its obligations under this Agreement, the
Registration Rights Agreement and the Warrant and to issue the Shares, the Warrant, the Warrant
Shares and any Blackout Shares (except to the extent that the number of Blackout Shares required to
be issued exceeds the number of authorized shares of Common Stock under the Charter); (ii) the
execution and delivery of this Agreement and the Registration Rights Agreement, and the execution,
issuance and delivery of the Warrant, by the Company and the consummation by it of the transactions
contemplated hereby and thereby have been duly and validly authorized by all necessary corporate
action and no further consent or authorization of the Company or its Board of Directors or
stockholders is required (other than as contemplated by Section 6.5); and (iii) each of this
Agreement and the Registration Rights Agreement has been duly executed and delivered, and the
Warrant has been duly executed, issued and delivered, by the Company and constitutes a valid and
binding obligation of the Company enforceable against the Company in accordance with its terms,
except as such enforceability may be limited by applicable bankruptcy, securities, insolvency, or
similar laws relating to, or affecting generally the enforcement of, creditors’ rights and remedies
or indemnification or by other equitable principles of general application.

     Section 4.3 Capitalization. The authorized capital stock of the Company and the
shares thereof issued and outstanding as of December 31, 2007 are set forth in a Commission
Document. All of the outstanding shares of the Common Stock have been duly and validly authorized
and issued, and are fully paid and non-assessable. Except as set forth in this Agreement, as
described in the Commission Documents or as disclosed on a schedule (the “Disclosure
Schedule”) previously delivered to the Investor, as of December 31, 2007, no shares of Common
Stock were entitled to preemptive rights or registration rights and there were no outstanding
options, warrants, scrip, rights issued by the Company to subscribe to, call or commitments of any
character whatsoever issued by the Company relating to, or securities or rights convertible into or
exchangeable for or giving any right to subscribe for, any shares of capital stock of the Company,
except for stock options and restricted stock units issued by the Company to its employees,
directors and consultants. Except as set forth in this Agreement, the Commission Documents, or as
previously disclosed to the Investor in the Disclosure Schedule, as of December 31, 2007, there
were no contracts, commitments, understandings, or arrangements by which the Company is or may
become bound to issue additional shares of the capital stock of the Company or options, securities
or rights convertible into or exchangeable for or giving any right to subscribe for any shares of
capital stock of the Company. Except as described in the Commission Documents or as previously
disclosed to the Investor in the Disclosure Schedule, as of the date hereof the Company is not a
party to any agreement granting registration rights to any Person with respect to any of its equity
or debt securities. Except as set forth in the Commission Documents or as previously disclosed to
the Investor in the Disclosure Schedule, as of the date hereof the Company is not a party to, and
it has no Knowledge of, any agreement restricting the voting or transfer of any shares of the
capital stock of the Company. The offer and sale of all capital stock, convertible securities,
rights, warrants, or options of the Company issued during the twenty-four month period immediately
prior to the Closing complied in all material respects with all applicable federal and state
securities laws, and no stockholder has a right of rescission or damages with respect thereto that
could reasonably be expected to have a Material Adverse Effect. The Company has furnished or made
available to the Investor true and correct copies of the Company’s Certificate of Incorporation, as
amended and in effect

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on the date hereof (the “Charter”), and the Company’s Bylaws, as amended and in effect
on the date hereof (the “Bylaws”).

     Section 4.4 Issuance of Shares. Subject to Section 6.5, the Shares, the Warrant and
the Warrant Shares have been, and any Blackout Shares will be, duly authorized by all necessary
corporate action (except to the extent that the number of Blackout Shares required to be issued
exceeds the number of authorized shares of Common Stock under the Charter) and, when issued and
paid for in accordance with the terms of this Agreement, the Registration Rights Agreement and the
Warrant, and subject to, and in reliance on, the representations, warranties and covenants made
herein by the Investor, the Shares and the Warrant Shares shall be validly issued and outstanding,
fully paid and non-assessable, and the Investor shall be entitled to all rights accorded to a
holder of shares of Common Stock.

     Section 4.5 No Conflicts. The execution, delivery and performance of this Agreement,
the Registration Rights Agreement, the Warrant and any other document or instrument contemplated
hereby or thereby, by the Company and the consummation by the Company of the transactions
contemplated hereby and thereby do not and shall not in any material respect: (i) result in the
violation of any provision of the Charter or Bylaws, (ii) conflict with, or constitute a default
(or an event which with notice or lapse of time or both would become a default) under, or give rise
to any rights of termination, amendment, acceleration or cancellation of, any material agreement,
mortgage, deed of trust, indenture, note, bond, license, lease agreement, instrument or obligation
to which the Company is a party where such default or conflict would constitute a Material Adverse
Effect, (iii) create or impose a lien, charge or encumbrance on any property of the Company under
any agreement or any commitment to which the Company is a party or by which the Company is bound or
by which any of its respective properties or assets are bound which would constitute a Material
Adverse Effect, (iv) result in a violation of any federal, state, local or foreign statute, rule,
regulation, order, writ, judgment or decree (including federal and state securities laws and
regulations) applicable to the Company or any of its subsidiaries or by which any property or asset
of the Company or any of its subsidiaries are bound or affected where such violation would
constitute a Material Adverse Effect, or (v) require any consent of any third-party that has not
been obtained pursuant to any material contract to which the Company is subject or to which any of
its assets, operations or management may be subject where the failure to obtain any such consent
would constitute a Material Adverse Effect. The Company is not required under federal, state or
local law, rule or regulation to obtain any consent, authorization or order of, or make any filing
or registration with, any court or governmental agency in order for it to execute, deliver or
perform any of its obligations under this Agreement, the Registration Rights Agreement or the
Warrant, or issue and sell the Shares, the Warrant Shares or the Blackout Shares (except to the
extent that the number of Blackout Shares required to be issued exceeds the number of authorized
shares of Common Stock under the Charter) in accordance with the terms hereof and thereof (other
than any filings that may be required to be made by the Company with the Commission, the
FINRA/NASDAQ or state securities commissions subsequent to the Closing, and, any registration
statement (including any amendment or supplement thereto) or any other filing or consent which may
be filed pursuant to this Agreement, the Registration Rights Agreement or the Warrant); provided
that, for purposes of the representation made in this sentence, the Company is assuming and relying
upon the accuracy of the relevant representations and agreements of the Investor herein.

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     Section 4.6 Commission Documents, Financial Statements.

          (a) The Common Stock is registered pursuant to Section 12(b) or 12(g) of the Exchange Act, and
since May 1, 2007 the Company has timely filed all reports, schedules, forms, statements and other
documents required to be filed by it with the Commission pursuant to the reporting requirements of
the Exchange Act, including pursuant to Section 13(a) or 15(d) of the Exchange Act (all of the
foregoing, including filings incorporated by reference therein, being referred to herein as the
“Commission Documents”). Except as previously disclosed to the Investor in writing, since
May 1, 2007 the Company has maintained all requirements for the continued listing or quotation of
its Common Stock, and such Common Stock is currently listed or quoted on the NASDAQ Global Market.
The Company has made available (including through the Commission’s EDGAR filing system) to the
Investor true and complete copies of the Commission Documents filed with the Commission since
January 1, 2007 and prior to the Closing Date. The Company has not provided to the Investor any
information which, according to applicable law, rule or regulation, should have been disclosed
publicly by the Company but which has not been so disclosed, other than with respect to the
transactions contemplated by this Agreement. As of its date, the Company’s Annual Report on Form
10-K for the year ended December 31, 2007 complied in all material respects with the requirements
of the Exchange Act and the rules and regulations of the Commission promulgated thereunder
applicable to such document, and, as of its date, after giving effect to the information disclosed
and incorporated by reference therein, to the Company’s Knowledge such Annual Report on Form 10-K
did not contain any untrue statement of a material fact or omit to state a material fact required
to be stated therein or necessary in order to make the statements therein, in light of the
circumstances under which they were made, not misleading. As of their respective dates, to the
Company’s Knowledge the financial statements, together with the related notes and schedules
thereto, of the Company included in the Commission Documents filed with the Commission since
January 1, 2007 complied as to form and substance in all material respects with all applicable
accounting requirements and the published rules and regulations of the Commission or other
applicable rules and regulations with respect thereto. Such financial statements, together with
the related notes and schedules thereto, have been prepared in accordance with generally accepted
accounting principles (“GAAP”) applied on a consistent basis during the periods involved
(except (i) as may be otherwise indicated in such financial statements or the notes thereto or
(ii) in the case of unaudited interim statements, to the extent they may not include footnotes or
may be condensed or summary statements), and fairly present in all material respects the financial
condition of the Company and its subsidiaries as of the dates thereof and the results of operations
and cash flows for the periods then ended (subject, in the case of unaudited statements, to normal
year-end audit adjustments).

          (b) The Company has timely filed with the Commission and made available to the Investor via
EDGAR or otherwise all certifications and statements required by (x) Rule 13a-14 or Rule 15d-14
under the Exchange Act or (y) 18 U.S.C. Section 1350 (Section 906 of the Sarbanes-Oxley Act of 2002
(“SOXA”)) with respect to all relevant Commission Documents. The Company is in compliance
in all material respects with the provisions of SOXA applicable to it as of the date hereof. The
Company maintains disclosure controls and procedures required by Rule 13a-15 or Rule 15d-15 under
the Exchange Act. As used in this Section 4.6(b), the term “file” shall be broadly construed to
include any manner in which a document or information is furnished, supplied or otherwise made
available to the Commission.

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     Section 4.7 No Material Adverse Change. Except as disclosed in the Commission
Documents or a press release of the Company, since December 31, 2007 no event or series of events
has or have occurred that would, individually or in the aggregate, have a Material Adverse Effect
on the Company.

     Section 4.8 No Undisclosed Liabilities. To the Company’s Knowledge, neither the
Company nor any of its subsidiaries has any liabilities, obligations, claims or losses (whether
liquidated or unliquidated, secured or unsecured, absolute, accrued, contingent or otherwise) that
would be required to be disclosed on a balance sheet of the Company or any subsidiary (including
the notes thereto) in conformity with GAAP and are not disclosed in the Commission Documents, other
than those incurred in the ordinary course of the Company’s or its subsidiaries respective
businesses since December 31, 2007 or which, individually or in the aggregate, do not or would not
have a Material Adverse Effect on the Company.

     Section 4.9 No Undisclosed Events or Circumstances. To the Company’s Knowledge, no
event or circumstance has occurred or exists with respect to the Company or its subsidiaries or
their respective businesses, properties, operations or financial condition, which, under applicable
law, rule or regulation, requires public disclosure or announcement by the Company but which has
not been so publicly announced or disclosed and which, individually or in the aggregate, would have
a Material Adverse Effect on the Company.

     Section 4.10 Actions Pending. There is no action, suit, claim, investigation or
proceeding pending or, to the Knowledge of the Company, threatened against the Company or any
subsidiary which questions the validity of this Agreement or the transactions contemplated hereby
or any action taken or to be taken pursuant hereto or thereto. Except as set forth in the
Commission Documents or in the Disclosure Schedule, there is no action, suit, claim, investigation
or proceeding pending or, to the Knowledge of the Company, threatened, against or involving the
Company, any subsidiary or any of their respective properties or assets, or to the Knowledge of the
Company involving any officers or directors, in their capacity as officers or directors, of the
Company or any of its subsidiaries, including, without limitation, any securities class action
lawsuit or stockholder derivative lawsuit, that could be reasonably expected to have a Material
Adverse. Except as set forth in the Commission Documents or as previously disclosed to the
Investor in writing, no judgment, order, writ, injunction or decree or award has been issued by or,
to the Knowledge of the Company, requested of any court, arbitrator or governmental agency which
could be reasonably expected to result in a Material Adverse Effect.

     Section 4.11 Compliance with Law. The business of the Company and its subsidiaries
has been and is presently being conducted in accordance with all applicable federal, state, local
and foreign governmental laws, rules, regulations and ordinances, except as set forth in the
Commission Documents or such that would not reasonably be expected to cause a Material Adverse
Effect. Except as set forth in the Commission Documents, each of the Company and each of its
subsidiaries has all franchises, permits, licenses, consents and other governmental or regulatory
authorizations and approvals necessary for the conduct of its business as now being conducted by
it, except for such franchises, permits, licenses, consents and other governmental or regulatory
authorizations and approvals, the failure to possess which, individually or in the aggregate, could
not reasonably be expected to have a Material Adverse Effect.

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     Section 4.12 Certain Fees. Except as expressly set forth in this Agreement, no
brokers, finders or financial advisory fees or commissions will be payable by the Company or any of
its subsidiaries in respect of the transactions contemplated by this Agreement.

     Section 4.13 Disclosure. To the Company’s Knowledge, neither this Agreement nor any
other documents, certificates or instruments furnished to the Investor by or on behalf of the
Company or any subsidiary in connection with the transactions contemplated by this Agreement
contain any untrue statement of a material fact or omit to state a material fact necessary in order
to make the statements made herein or therein, in the light of the circumstances under which they
were made herein or therein, not misleading.

     Section 4.14 Material Non-Public Information. Except for this Agreement and the
transactions contemplated hereby, neither the Company nor its employees have disclosed to the
Investor, any material non-public information that, according to applicable law, rule or
regulation, should have been disclosed publicly by the Company prior to the date hereof but which
has not been so disclosed.

     Section 4.15 Exemption from Registration; Valid Issuances. Subject to, and in
reliance on, the representations, warranties and covenants made herein by the Investor, the
issuance and sale of the Shares, the Warrant, the Warrant Shares and any Blackout Shares in
accordance with the terms and on the bases of the representations and warranties set forth in this
Agreement, may and shall be properly issued pursuant to Section 4(2), Regulation D and/or any other
applicable federal and state securities laws. Neither the sales of the Shares, the Warrant, the
Warrant Shares or any Blackout Shares pursuant to, nor the Company’s performance of its obligations
under, this Agreement, the Registration Rights Agreement, or the Warrant shall (i) result in the
creation or imposition of any liens, charges, claims or other encumbrances upon the Shares, the
Warrant Shares, any Blackout Shares or any of the assets of the Company, or (ii) except as
previously disclosed to the Investor in the Disclosure Schedule, entitle the holders of any
outstanding shares of capital stock of the Company to preemptive or other rights to subscribe to or
acquire the shares of Common Stock or other securities of the Company.

     Section 4.16 Form S-3 Eligibility. As of the date hereof, the Company qualifies to
register the Common Stock for resale by the Investor on Form S-3 promulgated by the Commission,
without reliance on General Instruction I.B.6. thereof, and the Company is not subject to any
volume limitations imposed by the Securities Act or the Commission in respect of such registration,
it being acknowledged that the Company may be subject to the shareholder approval rules of the
Principal Market.

     Section 4.17 No General Solicitation or Advertising in Regard to this Transaction.
Except for such registration statements filed as contemplated herein, neither the Company nor any
of its affiliates or any Person acting on its or their behalf (i) has conducted any general
solicitation (as that term is used in Rule 502(c) of Regulation D) or general advertising with
respect to any of the Shares, the Warrant, the Warrant Shares or any Blackout Shares or (ii) has
made any offers or sales of any security or solicited any offers to buy any security under any
circumstances that would require registration of the Shares under the Securities Act.

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     Section 4.18 No Integrated Offering. Neither the Company, nor any of its affiliates,
nor any person acting on its or their behalf has, directly or indirectly, made any offers or sales
of any security or solicited any offers to buy any security under circumstances that would require
registration under the Securities Act of shares of the Common Stock issuable hereunder with any
other offers or sales of securities of the Company.

     Section 4.19 Acknowledgment Regarding Investor’s Purchase of Shares. The Company
acknowledges and agrees that the Investor is acting solely in the capacity of an arm’s length
investor with respect to this Agreement and the transactions contemplated hereunder. The Company
further acknowledges that the Investor is not acting as a financial advisor or fiduciary of the
Company (or in any similar capacity) with respect to this Agreement and the transactions
contemplated hereunder and any advice given by the Investor or any of its representatives or agents
in connection with this Agreement and the transactions contemplated hereunder is merely incidental
to the Investor’s purchase of the Shares.

ARTICLE V

REPRESENTATIONS, WARRANTIES AND COVENANTS OF THE INVESTOR

     The Investor hereby makes the following representations, warranties and covenants to the
Company:

     Section 5.1 Organization and Standing of the Investor. The Investor is a company duly
organized, validly existing and in good standing under the laws of the British Virgin Islands.

     Section 5.2 Authorization and Power. The Investor has the requisite power and
authority to enter into and perform its obligations under this Agreement, the Warrant and the
Registration Rights Agreement and to purchase the Shares, any Blackout Shares, the Warrant and the
Warrant Shares in accordance with the terms hereof and thereof. The execution, delivery and
performance of this Agreement, the Warrant and the Registration Rights Agreement by Investor and
the consummation by it of the transactions contemplated hereby or thereby have been duly authorized
by all necessary corporate action, and no further consent or authorization of the Investor, its
Board of Directors or stockholders is required. Each of this Agreement and the Registration Rights
Agreement has been duly executed and delivered by the Investor and constitutes a valid and binding
obligation of the Investor enforceable against the Investor in accordance with its terms, except as
such enforceability may be limited by applicable bankruptcy, securities, insolvency,
reorganization, moratorium, liquidation, conservatorship, receivership, or similar laws relating
to, or affecting generally the enforcement of creditor’s rights and remedies or indemnification or
by other equitable principles of general application.

     Section 5.3 No Conflicts. The execution, delivery and performance of this Agreement,
the Registration Rights Agreement, the Warrant and any other document or instrument contemplated
hereby, by the Investor and the consummation of the transactions contemplated thereby do not
(i) violate any provision of the Investor’s charter documents or bylaws, (ii) conflict with, or
constitute a default (or an event which with notice or lapse of time or both would become a
default) under, or give to others any rights of termination, amendment, acceleration or
cancellation of, any material agreement, mortgage, deed of trust, indenture, note,

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bond, license, lease agreement, instrument or obligation to which the Investor is a party,
(iii) create or impose a lien, charge or encumbrance on any property of the Investor under any
agreement or any commitment to which the Investor is a party or by which the Investor is bound or
by which any of its respective properties or assets are bound, (iv) result in a violation of any
federal, state, local or foreign statute, rule, regulation, order, writ, judgment or decree
(including federal and state securities laws and regulations) applicable to the Investor or by
which any property or asset of the Investor are bound or affected, or (v) require the consent of
any third-party that has not been obtained pursuant to any material contract to which Investor is
subject or to which any of its assets, operations or management may be subject. The Investor is
not required under federal, state, foreign or local law, rule or regulation to obtain any consent,
authorization or order of, or make any filing or registration with, any court or governmental
agency in order for it to execute, deliver or perform any of its obligations under this Agreement,
the Registration Rights Agreement or the Warrant or to purchase or acquire the Shares, the Warrant,
the Warrant Shares or any Blackout Shares in accordance with the terms hereof, provided that, for
purposes of the representation made in this sentence, the Investor is assuming and relying upon the
accuracy of the relevant representations and agreements of the Company herein.

     Section 5.4 Financial Capability. The Investor has the financial capability to
perform all of its obligations under this Agreement, the Registration of Rights Agreement and the
Warrant, including the capability to purchase the Shares, the Warrant, the Warrant Shares and any
Blackout Shares in accordance with the terms hereof. The Investor has such knowledge and
experience in business and financial matters that it is capable of evaluating the merits and risks
of an investment in Common Stock and the Warrant. The Investor is an “accredited investor”
as defined in Regulation D. The Investor is a “sophisticated investor” as described in
Rule 506(b)(2)(ii) of Regulation D. The Investor acknowledges that an investment in the Common
Stock and the Warrant is speculative and involves a high degree of risk.

     Section 5.5 Information. The Investor and its advisors, if any, have been furnished
with all materials relating to the business, finances and operations of the Company and materials
relating to the offer and sale of the Shares, any Blackout Shares, the Warrant and the Warrant
Shares which have been requested by the Investor. The Investor has reviewed or received copies of
the Commission Documents. The Investor and its advisors, if any, have been afforded the
opportunity to ask questions of the Company. The Investor has sought such accounting, legal and
tax advice as it has considered necessary to make an informed investment decision with respect to
its acquisition of the Shares, any Blackout Shares, the Warrant and the Warrant Shares. The
Investor understands that it (and not the Company) shall be responsible for its own tax liabilities
that may arise as a result of this investment or the transactions contemplated by this Agreement.

     Section 5.6 Trading Restrictions. The Investor covenants that neither the Investor
nor any of its affiliates nor any entity managed or controlled by the Investor will, or cause or
assist any Person to, enter into or execute any “short sale” (as such term is defined in
Rule 200 of Regulation SHO, or any successor regulation, promulgated by the Commission under the
Exchange Act) of any securities of the Company, and that the Investor and its affiliates shall
comply with all other applicable laws.

- 15 -

 

     Section 5.7 Statutory Underwriter Status. The Investor acknowledges that, pursuant to
the Commission’s current interpretations of the Securities Act, the Investor will be disclosed as
an “underwriter” within the meaning of the Securities Act in the Registration Statement
(and amendments thereto) and in any Prospectus contained therein to the extent required by
applicable law.

     Section 5.8 Not an Affiliate. The Investor is not an officer, director or
“affiliate” (as defined in Rule 405 of the Securities Act) of the Company.

     Section 5.9 Manner of Sale. At no time was Investor presented with or solicited by or
through any leaflet, public promotional meeting, television advertisement or any other form of
general solicitation or advertising.

     Section 5.10 Prospectus Delivery. The Investor agrees that unless the Shares, the
Warrant Shares or any Blackout Shares are eligible for resale pursuant to all the conditions of
Rule 144, it will resell the Shares, the Warrant Shares and any Blackout Shares only pursuant to
the Registration Statement, in a manner described under the caption “Plan of Distribution”
in the Registration Statement, and in a manner in compliance with all applicable securities laws,
including, without limitation, any applicable prospectus delivery requirements of the Securities
Act and the insider trading restrictions of the Exchange Act.

ARTICLE VI

COVENANTS OF THE COMPANY

     The Company covenants with the Investor as follows, which covenants are for the benefit of the
Investor and its permitted assignees (as defined herein):

     Section 6.1 Securities Compliance. The Company shall notify the Commission and the
Principal Market, if and as applicable, in accordance with their respective rules and regulations,
of the transactions contemplated by this Agreement, and shall use commercially reasonable efforts
to take all other necessary action and proceedings as may be required and permitted by applicable
law, rule and regulation, for the legal and valid issuance of the Shares, the Warrant Shares and
the Blackout Shares, if any, to the Investor. Each Commission Document to be filed with the
Commission after the Closing Date and incorporated by reference in the Registration Statement and
Prospectus, when such document becomes effective or is filed with the Commission, as the case may
be, shall comply in all material respects with the requirements of the Securities Act or the
Exchange Act, as applicable, and other federal, state and local laws, rules and regulations
applicable to it, and shall not contain any untrue statement of a material fact or omit to state a
material fact required to be stated therein or necessary in order to make the statements therein,
in light of the circumstances under which they were made, not misleading.

     Section 6.2 Reservation of Common Stock. As of the date hereof, the Company has
available and the Company shall reserve and keep available at all times, free of preemptive rights
and other similar contractual rights of stockholders, shares of Common Stock for the purpose of
enabling the Company to satisfy any obligation to issue the Shares in connection with all Draw
Downs contemplated hereunder and the Warrant Shares. The number of shares so reserved from

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time to time, as theretofore increased or reduced as hereinafter provided, may be reduced by
the number of shares actually delivered hereunder.

     Section 6.3 Registration and Listing. During the Commitment Period, the Company shall
use commercially reasonable efforts to: (i) take all action necessary to cause its Common Stock to
continue to be registered under Section 12(b) or 12(g) of the Exchange Act, (ii) comply in all
material respects with its reporting and filing obligations under the Exchange Act, (iii) prevent
the termination or suspension of such registration, or the termination or suspension of its
reporting and filing obligations under the Exchange Act or Securities Act (except as expressly
permitted herein). The Company shall use commercially reasonable efforts to maintain the listing
and trading of its Common Stock and the listing of the Shares purchased by Investor hereunder on
the Principal Market (including, without limitation, maintaining sufficient net tangible assets)
and will comply in all material respects with the Company’s reporting, filing and other obligations
under the bylaws or rules of the FINRA and the Principal Market. The Company will not be required
to carry out any action pursuant to this Agreement, the Registration Rights Agreement or the
Warrant that would adversely impact the listing of the Company’s securities on the Principal
Market, which Principal Market may be changed by the Company in the future in the Company’s
discretion.

     Section 6.4 Registration Statement. Without the prior written consent of the
Investor, the Registration Statement shall be used solely in connection with the transactions
between the Company and the Investor contemplated hereby.

     Section 6.5 Compliance with Laws.

          (a) The Company shall comply, and cause each subsidiary to comply, with all applicable laws,
rules, regulations and orders, noncompliance with which would reasonably be expected to have a
Material Adverse Effect. Without limiting the generality of the foregoing, neither the Company nor
any of its officers, directors or affiliates will take, directly or indirectly, any action designed
or intended to stabilize or manipulate the price of any security of the Company, or which would in
the future reasonably be expected to cause or result in, stabilization or manipulation of the price
of any security of the Company, in each case in contravention of applicable laws, rules,
regulations or orders or available Commission interpretations thereof.

          (b) Without the consent of its stockholders in accordance with FINRA and The NASDAQ Stock
Market LLC rules, the Company will not be obligated to issue, and the Investor will not be
obligated to purchase, any Shares or Blackout Shares which would result in the issuance under this
Agreement, the Warrant and the Registration Rights Agreement of Shares, Warrant Shares and Blackout
Shares (collectively) representing more than the applicable percentage under the rules of the FINRA
and The NASDAQ Stock Market LLC , including, without limitation, NASDAQ Marketplace Rule 4350(i),
that would require stockholder approval of the issuance thereof. Nothing herein shall compel the
Company to seek such consent of its stockholders. In addition, the Company will not be obligated
to issue, and the Investor will not be obligated to purchase, any Shares, Warrant Shares or
Blackout Shares if as a result of the acquisition of such Shares, Warrant Shares and/or Blackout
Shares, the Company would be required to file any notification or report forms under the
Hart-Scott-Rodino Antitrust

- 17 -

 

Improvements Act of 1976, as amended. Nothing herein shall compel the Company to file such
notification and report forms.

     Section 6.6 Other Financing. Nothing in this Agreement shall be construed to restrict
the right of the Company to offer, sell and/or issue securities of any kind whatsoever, provided
such transaction is not a Prohibited Transaction (as defined below) (any such transaction that is
not a Prohibited Transaction is referred to in this Agreement as a “Permitted
Transaction”). Without limiting the generality of the preceding sentence, the Company may,
without the prior written consent of the Investor, (i) establish stock option or award plans or
agreements (for directors, employees, consultants and/or advisors), and issue securities
thereunder, and amend such plans or agreements, including increasing the number of shares available
thereunder, (ii) issue equity securities to finance, or otherwise in connection with, the
acquisition, license or sale of one or more other companies, equipment, technologies or lines of
business, (iii) issue shares of Common Stock and/or Preferred Stock in connection with the
Company’s option or award plans, stock purchase plans, stock bonus programs, rights plans, warrants
or options, (iv) issue shares of Common Stock and/or Preferred Stock in connection with the
acquisition, license or sale of products, licenses, equipment or other assets and strategic
transactions or joint ventures; (v) issue shares of Common and/or Preferred Stock to employees,
consultants and/or advisors as consideration for services rendered or to be rendered, (vi) issue
and sell equity or debt securities in a public offering, (vii) issue and sell and equity or debt
securities in a private placement (other than in connection with any Prohibited Transaction),
(viii) issue equity securities to equipment lessors, equipment vendors, banks or similar lending
institutions in connection with leases or loans, or in connection with strategic commercial or
licensing transactions, (ix) issue securities in connection with any stock split, stock dividend,
recapitalization, reclassification or similar event by the Company, and (x) issue shares of Common
Stock to the Investor under any other agreement entered into between the Investor and the Company.

     Section 6.7 Prohibited Transactions. Except as set forth on Schedule 6.7 of the
Disclosure Schedule and as permitted by Section 6.6, during the term of this Agreement, the Company
shall not enter into any Prohibited Transaction without the prior written consent of the Investor,
which consent may be withheld at the sole discretion of the Investor. For the purposes of this
Agreement, the term “Prohibited Transaction” shall refer to the issuance by the Company of
any “future priced securities,” which shall mean the issuance of shares of Common Stock or
securities of any type whatsoever that are, or may become, convertible or exchangeable into shares
of Common Stock where the purchase, conversion or exchange price for such Common Stock is
determined using any floating discount or other post-issuance adjustable discount to the market
price of Common Stock, including, without limitation, pursuant to any equity line or other
financing that is substantially similar to the financing provided for under this Agreement,
provided that any future issuance by the Company of a convertible security (“Convertible
Security”) that contains provisions that adjust the conversion price of such Convertible
Security in the event of stock splits, dividends, distributions or similar events or pursuant to
anti-dilution provisions shall not be a Prohibited Transaction.

     Section 6.8 Corporate Existence. The Company shall take all steps necessary to
preserve and continue the corporate existence of the Company; provided, however, that nothing in
this Agreement shall be deemed to prohibit the Company from engaging in any Excluded Merger or Sale
with another Person, subject to the terms of the Warrant.

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     Section 6.9 Non-Disclosure of Non-Public Information. Except as otherwise expressly
provided in this Agreement, the Registration Rights Agreement or the Warrant, none of the Company,
its officers, directors, employees nor agents shall disclose material non-public information to the
Investor, its advisors or representatives.

     Section 6.10 Notice of Certain Events Affecting Registration; Suspension of Right to
Request a Draw Down. The Company shall promptly notify the Investor upon the occurrence of any
of the following events in respect of the Registration Statement or the Prospectus related to the
offer, issuance and sale of the Shares and the Warrant Shares hereunder: (i) receipt of any request
for material additional information by the Commission or any other federal or state governmental
authority or for amendments or supplements to the Registration Statement or the Prospectus during
the period of effectiveness of the Registration Statement; (ii) the issuance by the Commission or
any other federal or state governmental authority of any stop order suspending the effectiveness of
the Registration Statement or the initiation of any proceedings for that purpose; (iii) receipt of
any notification with respect to the suspension of the qualification or exemption from
qualification of any of the Registrable Securities for sale in any jurisdiction or the initiation
or threatening of any proceeding for such purpose; and (iv) unless disclosed in Commission
Documents incorporated by reference into the Registration Statement or Prospectus, the Company
becoming aware of the happening of any event, which makes any statement of a material fact made in
the Registration Statement or Prospectus untrue in a material respect or which requires the making
of any additions to or changes to the statements then made in the Registration Statement or
Prospectus in order to state a material fact required by the Securities Act to be stated therein or
necessary in order to make the statements then made therein, in light of the circumstances under
which they were made, not misleading, or of the necessity to amend the Registration Statement or
supplement the Prospectus to comply with the Securities Act or any other law. If at any time the
Commission shall issue any stop order suspending the effectiveness of the Registration Statement,
the Company shall use commercially reasonable efforts to obtain the withdrawal of such order at the
earliest possible time. The Company shall not be required to disclose to the Investor the
substance or specific reasons of any of the events set forth in clauses (i) through (iv) of the
previous sentence, only that the event has occurred. The Company shall not request a Draw Down
during the continuation of any of the foregoing events.

     Section 6.11 Amendments to the Registration Statement. After the Registration
Statement has been declared effective by the Commission, the Company shall not (a) file any
amendment to the Registration Statement or make any amendment or supplement to the Prospectus of
which the Investor shall not have been previously or be simultaneously advised; provided, however,
that the Company shall, to the extent it deems advisable, and without the prior consent of or
notice to Investor, supplement the Prospectus within two Trading Days following the Settlement Date
for each Draw Down solely to reflect the issuance of Shares with respect to such Draw Down, and (b)
so long as, in the reasonable opinion of counsel for the Investor, a Prospectus is required to be
delivered in connection with sales of the Shares by the Investor, if the Company files any
information, documents or reports that are incorporated by reference in the Registration Statement
pursuant to the Exchange Act, the Company shall, if requested in writing by the Investor, deliver a
copy of such information, documents or reports to the Investor promptly following such filing to
the extent such information, documents or reports are not available on the Commission’s EDGAR
filing system.

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     Section 6.12 Prospectus Delivery. From time to time for such period as in the
reasonable opinion of counsel for the Investor a prospectus is required by the Securities Act to be
delivered in connection with sales by the Investor, the Company will expeditiously deliver to the
Investor, without charge, as many copies of the Prospectus (and of any amendment or supplement
thereto) as the Investor may reasonably request. Subject to the Registration Rights Agreement, the
Company consents to the use of the Prospectus (and of any amendment or supplement thereto) in
accordance with the provisions of the Securities Act and state securities laws in connection with
the offering and sale of the Shares and the Warrant Shares and for such period of time thereafter
as the Prospectus is required by the Securities Act to be delivered in connection with sales of the
Shares and the Warrant Shares. Notwithstanding the foregoing, in no event shall the Company be
under any obligation to supplement the Prospectus or to reflect the issuance of any Shares pursuant
to a Draw Down or deliver any Prospectus as so supplemented at any time prior to the Trading Day
following the Settlement Date with respect to such Shares.

ARTICLE VII

CONDITIONS TO THE OBLIGATION OF THE INVESTOR

TO ACCEPT A DRAW DOWN

     The obligation of the Investor hereunder to accept a Draw Down Notice and to acquire and pay
for the Shares in accordance therewith is subject to the satisfaction or waiver, at each Condition
Satisfaction Date, of each of the conditions set forth below. Other than those conditions set
forth in Section 7.12 which are for the Company’s sole benefit and may be waived by the Company at
any time in its sole discretion, the conditions are for the Investor’s sole benefit and may be
waived by the Investor at any time in its sole discretion. As used in this Agreement, the term
“Condition Satisfaction Date” shall mean, with respect to each Draw Down, the date on which
the applicable Draw Down Notice is delivered to the Investor and each Settlement Date in respect of
the applicable Draw Down Pricing Period.

     Section 7.1 Accuracy of the Company’s Representations and Warranties. Each of the
representations and warranties of the Company shall be true and correct in all material respects as
of the date when made as though made at that time except for representations and warranties that
are expressly made as of a particular date.

     Section 7.2 Performance by the Company. The Company shall have, in all material
respects, performed, satisfied and complied with all covenants, agreements and conditions required
by this Agreement, the Registration Rights Agreement and the Warrant to be performed, satisfied or
complied with by the Company.

     Section 7.3 Compliance with Law. The Company shall have complied in all respects with
all applicable federal, state and local governmental laws, rules, regulations and ordinances in
connection with the execution, delivery and performance of this Agreement and the consummation of
the transactions contemplated hereby except for any failures to so comply which could not
reasonably be expected to have a Material Adverse Effect.

     Section 7.4 Effective Registration Statement. Upon the terms and subject to the
conditions set forth in the Registration Rights Agreement, the Registration Statement shall have
previously become effective and shall remain effective and (i) neither the Company nor the

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Investor shall have received notice that the Commission has issued or intends to issue a stop
order with respect to the Registration Statement or that the Commission otherwise has suspended or
withdrawn the effectiveness of the Registration Statement, either temporarily or permanently, or
intends or has threatened to do so (unless the Commission’s concerns have been addressed and the
Investor is reasonably satisfied that the Commission no longer is considering or intends to take
such action), and (ii) no other suspension of the use or withdrawal of the effectiveness of the
Registration Statement or the Prospectus shall exist.

     Section 7.5 No Knowledge. The Company shall have no Knowledge of any event that could
reasonably be expected to have the effect of causing the Registration Statement with respect to the
resale of the Registrable Securities by the Investor to be suspended or otherwise ineffective
(which event is reasonably likely to occur within eight Trading Days following the Trading Day on
which a Draw Down Notice is delivered) as of the Settlement Date.

     Section 7.6 No Suspension. Trading in the Company’s Common Stock shall not have been
suspended by the Commission, the Principal Market or the FINRA and trading in securities generally
as reported on the Principal Market shall not have been suspended or limited as of the Condition
Satisfaction Date.

     Section 7.7 No Injunction. No statute, rule, regulation, order, decree, writ, ruling
or injunction shall have been enacted, entered, promulgated, endorsed or, to the Knowledge of the
Company, threatened by any court or governmental authority of competent jurisdiction which
prohibits the consummation of or which would materially modify or delay any of the transactions
contemplated by this Agreement.

     Section 7.8 No Proceedings or Litigation. No action, suit or proceeding before any
arbitrator or any court or governmental authority shall be pending or, to the Knowledge of the
Company, threatened, and, to the Knowledge of the Company no inquiry or investigation by any
governmental authority shall be threatened, against the Company or any subsidiary, or any of the
officers, directors or affiliates of the Company or any subsidiary, seeking to enjoin, prevent or
change the transactions contemplated by this Agreement, or seeking material damages in connection
with such transactions.

     Section 7.9 Sufficient Shares Registered for Resale. The Company shall have
sufficient Shares, calculated using the closing trade price of the Common Stock as of the Trading
Day immediately preceding such Draw Down Notice, registered under the Registration Statement to
issue and sell such Shares in accordance with such Draw Down Notice.

     Section 7.10 Warrant. The Warrant shall have been duly executed, delivered and issued
to the Investor, and the Company shall not be in default in any material respect under any of the
provisions thereof, provided that any refusal by or failure of the Company to issue and deliver
Warrant Shares in respect of any exercise (in whole or in part) thereof shall be deemed to be
material for the purposes of this Section 7.10.

     Section 7.11 Opinion of Counsel. The Investor shall have received the form of opinion
mutually agreed to between the parties on the date of this Agreement.

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     Section 7.12 Accuracy of Investor’s Representation and Warranties. The
representations and warranties of the Investor shall be true and correct in all material respects
as of the date when made as though made at that time except for representations and warranties that
are made as of a particular date.

ARTICLE VIII

TERMINATION

     Section 8.1 Term. Unless otherwise terminated in accordance with Section 8.2 below,
this Agreement shall terminate upon the earlier to occur of (i) the expiration of the Commitment
Period or (ii) the issuance of Shares pursuant to this Agreement in an amount equal to the Maximum
Commitment Amount.

     Section 8.2 Other Termination.

          (a) The Investor may terminate this Agreement upon (x) one (1) Trading Day’s notice if the
Company enters into any Prohibited Transaction as set forth in Section 6.7 without the Investor’s
prior written consent, or (y) one (1) Trading Day’s notice if the Investor provides written notice
of a Material Adverse Effect to the Company, and such Material Adverse Effect continues for a
period of ten (10) Trading Days after the receipt by the Company of such notice.

          (b) The Investor may terminate this Agreement upon one (1) Trading Day’s notice to the Company
at any time in the event that the Registration Statement is not initially declared effective in
accordance with the Registration Rights Agreement, provided, however, that in the event the
Registration Statement is declared effective prior to the delivery of such notice, the Investor
shall thereafter have no right to terminate this Agreement pursuant to this Section 8.2(b).

          (c) The Company may terminate this Agreement upon one (1) Trading Day’s notice; provided,
however, that the Company shall not terminate this Agreement pursuant to this Section 8.2(c) during
any Draw Down Pricing Period; provided further, that, in the event of any termination of this
Agreement by the Company hereunder, so long as the Investor owns Shares purchased hereunder and/or
Warrant Shares, unless all of such shares of Common Stock may be resold by the Investor without
registration and without any time, volume or manner limitations pursuant to Rule 144(b) (or any
similar provision then in effect) under the Securities Act, the Company shall not suspend or
withdraw the Registration Statement or otherwise cause the Registration Statement to become
ineffective, or voluntarily delist the Common Stock from, the Principal Market without listing the
Common Stock on another Principal Market.

          (d) Each of the parties hereto may terminate this Agreement upon one (1) Trading Day’s notice
if the other party has breached a material representation, warranty or covenant to this Agreement
and such breach is not remedied within ten (10) Trading Days after notice of such breach is
delivered to the breaching party.

     Section 8.3 Effect of Termination. In the event of termination by the Company or the
Investor, written notice thereof shall forthwith be given to the other party and the transactions
contemplated by this Agreement shall be terminated without further action by either party. If

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this Agreement is terminated as provided in Section 8.1 or 8.2 herein, this Agreement shall
become void and of no further force and effect, except as provided in Section 10.13. Nothing in
this Section 8.3 shall be deemed to release the Company or the Investor from any liability for any
breach under this Agreement occurring prior to such termination, or to impair the rights of the
Company and the Investor to compel specific performance by the other party of its obligations under
this Agreement arising prior to such termination.

ARTICLE IX

INDEMNIFICATION

     Section 9.1 Indemnification.

          (a) Except as otherwise provided in this Article IX, unless disputed as set forth in Section
9.2, the Company agrees to indemnify, defend and hold harmless the Investor and its affiliates and
their respective officers, directors, agents, employees, subsidiaries, partners, members and
controlling persons (each, an “Investor Indemnified Party”), to the fullest extent
permitted by law from and against any and all Damages directly resulting from or directly arising
out of any breach of any representation or warranty, covenant or agreement (except as otherwise
specifically provided) by the Company in this Agreement, the Registration Rights Agreement or the
Warrant; provided, however, that the Company shall not be liable under this Article IX to an
Investor Indemnified Party to the extent that such Damages resulted or arose from the breach by an
Investor Indemnified Party of any representation, warranty, covenant or agreement of an Investor
Indemnified Party contained in this Agreement, the Registration Rights Agreement or the Warrant or
the negligence, recklessness, willful misconduct or bad faith of an Investor Indemnified Party.
The parties intend that any Damages subject to indemnification pursuant to this Article IX will be
net of insurance proceeds (which the Investor Indemnified Party agrees to use commercially
reasonable efforts to recover). Accordingly, the amount which the Company is required to pay to
any Investor Indemnified Party hereunder (a “Company Indemnity Payment”) will be reduced by
any insurance proceeds actually recovered by or on behalf of any Investor Indemnified Party in
reduction of the related Damages. In addition, if an Investor Indemnified Party receives a Company
Indemnity Payment required by this Article IX in respect of any Damages and subsequently receives
any such insurance proceeds, then the Investor Indemnified Party will pay to the Company an amount
equal to the Company Indemnity Payment received less the amount of the Company Indemnity Payment
that would have been due if the insurance proceeds had been received, realized or recovered before
the Company Indemnity Payment was made.

          (b) Except as otherwise provided in this Article IX, unless disputed as set forth in Section
9.2, the Investor agrees to indemnify, defend and hold harmless the Company and its affiliates and
their respective officers, directors, agents, employees, subsidiaries, partners, members and
controlling persons (each, a “Company Indemnified Party”), to the fullest extent permitted
by law from and against any and all Damages directly resulting from or directly arising out of any
breach of any representation or warranty, covenant or agreement by the Investor in this Agreement,
the Registration Rights Agreement or the Warrant; provided, however, that the Investor shall not be
liable under this Article IX to a Company Indemnified Party to the extent that such Damages
resulted or arose from the breach by a Company Indemnified Party of any representation, warranty,
covenant or agreement of a Company Indemnified Party contained in

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this Agreement, the Registration Rights Agreement or the Warrant or the negligence,
recklessness, willful misconduct or bad faith of a Company Indemnified Party. The parties intend
that any Damages subject to indemnification pursuant to this Article IX will be net of insurance
proceeds (which the Company agrees to use commercially reasonable efforts to recover).
Accordingly, the amount which the Investor is required to pay to any Company Indemnified Party
hereunder (an “Investor Indemnity Payment”) will be reduced by any insurance proceeds
theretofore actually recovered by or on behalf of any Company Indemnified Party in reduction of the
related Damages. In addition, if a Company Indemnified Party receives an Investor Indemnity
Payment required by this Article IX in respect of any Damages and subsequently receives any such
insurance proceeds, then the Company Indemnified Party will pay to the Investor an amount equal to
the Investor Indemnity Payment received less the amount of the Investor Indemnity Payment that
would have been due if the insurance proceeds had been received, realized or recovered before the
Investor Indemnity Payment was made.

     Section 9.2 Notification of Claims for Indemnification. Each party entitled to
indemnification under this Article IX (an “Indemnified Party”) shall, promptly after the
receipt of notice of the commencement of any claim against such Indemnified Party in respect of
which indemnity may be sought from the party obligated to indemnify such Indemnified Party under
this Article IX (the “Indemnifying Party”), notify the Indemnifying Party in writing of the
commencement thereof. Any such notice shall describe the claim in reasonable detail. The failure
of any Indemnified Party to so notify the Indemnifying Party of any such action shall not relieve
the Indemnifying Party from any liability which it may have to such Indemnified Party (a) other
than pursuant to this Article IX or (b) under this Article IX unless, and only to the extent that,
such failure results in the Indemnifying Party’s forfeiture of substantive rights or defenses or
the Indemnifying Party is prejudiced by such delay. The procedures listed below shall govern the
procedures for the handling of indemnification claims.

          (a) Any claim for indemnification for Damages that do not result from a Third Party Claim as
defined in the following paragraph, shall be asserted by written notice given by the Indemnified
Party to the Indemnifying Party. Such Indemnifying Party shall have a period of thirty (30) days
after the receipt of such notice within which to respond thereto. If such Indemnifying Party does
not respond within such thirty (30) day period, such Indemnifying Party shall be deemed to have
refused to accept responsibility to make payment as set forth in Section 9.1. If such Indemnifying
Party does not respond within such thirty (30) day period or rejects such claim in whole or in
part, the Indemnified Party shall be free to pursue such remedies as specified in this Agreement.

          (b) If an Indemnified Party shall receive notice or otherwise learn of the assertion by a
person or entity not a party to this Agreement of any threatened legal action or claim
(collectively a “Third Party Claim”), with respect to which an Indemnifying Party may be
obligated to provide indemnification, the Indemnified Party shall give such Indemnifying Party
written notice thereof within twenty (20) days after becoming aware of such Third Party Claim.

          (c) An Indemnifying Party may elect to defend (and, unless the Indemnifying Party has
specified any reservations or exceptions, to seek to settle or compromise) at such Indemnifying
Party’s own expense and by such Indemnifying Party’s own counsel, any Third Party Claim. Within
thirty (30) days after the receipt of notice from an Indemnified Party (or

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sooner if the nature of such Third Party Claim so requires), the Indemnifying Party shall
notify the Indemnified Party whether the Indemnifying Party will assume responsibility for
defending such Third Party Claim, which election shall specify any reservations or exceptions. If
such Indemnifying Party does not respond within such thirty (30) day period or rejects such claim
in whole or in part, the Indemnified Party shall be free to pursue such remedies as specified in
this Agreement. In case any such Third Party Claim shall be brought against any Indemnified Party,
and it shall notify the Indemnifying Party of the commencement thereof, the Indemnifying Party
shall be entitled to assume the defense thereof at its own expense, with counsel satisfactory to
such Indemnified Party in its reasonable judgment; provided, however, that any Indemnified Party
may, at its own expense, retain separate counsel to participate in such defense at its own expense.
Notwithstanding the foregoing, in any Third Party Claim in which both the Indemnifying Party, on
the one hand, and an Indemnified Party, on the other hand, are, or are reasonably likely to become,
a party, such Indemnified Party shall have the right to employ separate counsel and to control its
own defense of such claim if, in the reasonable opinion of counsel to such Indemnified Party,
either (x) one or more significant defenses are available to the Indemnified Party that are not
available to the Indemnifying Party or (y) a conflict or potential conflict exists between the
Indemnifying Party, on the one hand, and such Indemnified Party, on the other hand, that would make
such separate representation advisable; provided, however, that in such circumstances the
Indemnifying Party (i) shall not be liable for the fees and expenses of more than one counsel to
all Indemnified Parties and (ii) shall reimburse the Indemnified Parties for such reasonable fees
and expenses of such counsel incurred in any such Third Party Claim, as such expenses are incurred,
provided that the Indemnified Parties agree to repay such amounts if it is ultimately determined
that the Indemnifying Party was not obligated to provide indemnification under this Article IX.
The Indemnifying Party agrees that it will not, without the prior written consent of the
Indemnified Party, settle, compromise or consent to the entry of any judgment in any pending or
threatened claim relating to the matters contemplated hereby (if any Indemnified Party is a party
thereto or has been actually threatened to be made a party thereto) unless such settlement,
compromise or consent includes an unconditional release of such Indemnified Party from all
liability arising or that may arise out of such claim. The Indemnifying Party shall not be liable
for any claim effected against an Indemnified Party without the Indemnifying Party’s written
consent, which consent shall not be unreasonably withheld, conditioned or delayed. The rights
accorded to an Indemnified Party hereunder shall be in addition to any rights that any Indemnified
Party may have at common law, by separate agreement or otherwise; provided, however, that
notwithstanding the foregoing or anything to the contrary contained in this Agreement, nothing in
this Article IX shall restrict or limit any rights that any Indemnified Party may have to seek
equitable relief.

ARTICLE X

MISCELLANEOUS

     Section 10.1 Fees and Expenses.

          (a) Each of the Company and the Investor agrees to pay its own expenses incident to the
performance of its obligations hereunder, except that the Company shall be solely responsible for
(i) all reasonable attorneys fees and legal expenses incurred by the Investor in connection with
the preparation, negotiation, execution and delivery of this Agreement, the Registration Rights
Agreement and the Warrant, and review of the Registration Statement, and in

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connection with any amendments, modifications or waivers of this Agreement, (ii) subject in
all cases to Section 10.1(b) hereof, all reasonable fees and expenses incurred in connection with
the Investor’s enforcement of this Agreement, including, without limitation, all reasonable
attorneys fees and legal expenses, (iii) due diligence expenses incurred by the Investor during the
term of this Agreement equal to $12,500 per calendar quarter, and (iv) all stamp or other similar
taxes and duties, if any, levied in connection with issuance of the Shares pursuant hereto;
provided, however, that in each of the above instances the Investor shall provide customary
supporting invoices or similar documentation in reasonable detail describing such expenses
(however, the Investor shall not be obligated to provide detailed time sheets); and provided
further, that the maximum aggregate amount payable by the Company pursuant to clauses (i) and (ii)
above shall be $75,000 and the Investor shall bear all fees and expenses in excess of $75,000 in
connection with the events described in clauses (i) and (ii) above.

          (b) If any action at law or in equity is necessary to enforce or interpret the terms of this
Agreement, the Registration Rights Agreement or the Warrant, the prevailing party shall be entitled
to reasonable fees, costs and necessary disbursements in addition to any other relief to which such
party may be entitled.

     Section 10.2 Reporting Entity for the Common Stock. The reporting entity relied upon
for the determination of the trading price or trading volume of the Common Stock on any given
Trading Day for the purposes of this Agreement shall be Bloomberg, L.P. or any successor thereto.
The written mutual consent of the Investor and the Company shall be required to employ any other
reporting entity.

     Section 10.3 Brokerage. Each of the parties hereto represents that it has had no
dealings in connection with this transaction with any finder or broker who will demand payment of
any fee or commission from the other party. The Company on the one hand, and the Investor, on the
other hand, agree to indemnify the other against and hold the other harmless from any and all
liabilities to any Persons claiming brokerage commissions or finder’s fees on account of services
purported to have been rendered on behalf of the indemnifying party in connection with this
Agreement or the transactions contemplated hereby.

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     Section 10.4 Notices. All notices, demands, requests, consents, approvals, and other
communications required or permitted hereunder shall be in writing and, unless otherwise specified
herein, shall be (i) personally served, (ii) deposited in the mail, registered or certified, return
receipt requested, postage prepaid, (iii) delivered by reputable air courier service with charges
prepaid, or (iv) transmitted by hand delivery, telegram, or facsimile, addressed as set forth below
or to such other address as such party shall have specified most recently by written notice given
in accordance herewith, in each case with a copy to the e-mail address set forth beside the
facsimile number for the addressee below. Any notice or other communication required or permitted
to be given hereunder shall be deemed effective (a) upon hand delivery or delivery by facsimile,
with accurate confirmation generated by the transmitting facsimile machine, at the address or
number designated below (if delivered on a Trading Day during normal business hours where such
notice is to be received), or the first Trading Day following such delivery (if delivered other
than on a Trading Day during normal business hours where such notice is to be received) or (b) on
the second Trading Day following the date of mailing by express courier service, fully prepaid,
addressed to such address, or upon actual receipt of such mailing, whichever shall first occur.
The addresses for such communications shall be:

If to the Company:

EPIX Pharmaceuticals, Inc.

4 Maguire Road

Lexington, Massachusetts 02421

Facsimile: 781-761-7632

Attention: Chief Financial Officer

Email: kdrapkin@epixpharma.com

with a copy (which shall not constitute notice) to:

Goodwin Proctor LLP

53 State Street

Boston, MA 02109

Facsimile: 617-523-1231

Attention: Edward A. King, Esq. – eking@goodwinproctor.com

if to the Investor:

Kingsbridge Capital Limited

Attention: Mr. Antony Gardner-Hillman

P.O. Box 1075

Elizabeth House

9 Castle Street

St. Helier

Jersey

JE42QP

Channel Islands

Telephone: 011-44-1534-636-041

Facsimile: 011-44-1534-636-042

Email: admin@kingsbridgecap.com; and adamgurney@kingsbridgecap.com

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with a copy (which shall not constitute notice) to:

Kingsbridge Corporate Services Limited

Kingsbridge House

New Abbey

Kilcullen, County Kildare

Republic of Ireland

Telephone: 011-353-45-481-811

Facsimile: 011-353-45-482-003

Email: adamgurney@kingsbridge.ie; emmagalway@kingsbridge.ie; and pwhelan@kingsbridge.ie

and another copy (which shall not constitute notice) to:

Stroock & Stroock & Lavan LLP

180 Maiden Lane

New York, NY 10038

Facsimile: (212) 806-5400

Attention: Keith M. Andruschak, Esq. – kandruschak@stroock.com

     Either party hereto may from time to time change its contact information for notices under
this Section by giving at least ten (10) days’ prior written notice of such changed contact
information to the other party hereto.

     Section 10.5 Assignment. Neither this Agreement nor any rights of the Investor or the
Company hereunder may be assigned by either party to any other Person.

     Section 10.6 Amendment; No Waiver. No party shall be liable or bound to any other
party in any manner by any warranties, representations or covenants except as specifically set
forth in this Agreement, the Warrant and the Registration Rights Agreement. Except as expressly
provided in this Agreement, neither this Agreement nor any term hereof may be amended, waived,
discharged or terminated other than by a written instrument signed by both parties hereto. The
failure of either party to insist on strict compliance with this Agreement, or to exercise any
right or remedy under this Agreement, shall not constitute a waiver of any rights provided under
this Agreement, nor estop the parties from thereafter demanding full and complete compliance nor
prevent the parties from exercising such a right or remedy in the future.

     Section 10.7 Entire Agreement. This Agreement, the Registration Rights Agreement and
the Warrant set forth the entire agreement and understanding of the parties relating to the subject
matter hereof and supersedes all prior and contemporaneous agreements, negotiations and
understandings between the parties, both oral and written, relating to the subject matter hereof.

     Section 10.8 Severability. If any provision of this Agreement becomes or is declared
by a court of competent jurisdiction to be illegal, unenforceable or void, this Agreement shall
continue in full force and effect without said provision; provided that, if the severance of such
provision materially changes the economic benefits of this Agreement to either party as such

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benefits are anticipated as of the date hereof, then such party may terminate this Agreement
on five (5) Trading Days prior written notice to the other party. In such event, the Registration
Rights Agreement will terminate simultaneously with the termination of this Agreement; provided
that in the event that this Agreement is terminated by the Company in accordance with this Section
10.8 and the Warrant Shares either have not been registered for resale by the Investor in
accordance with the Registration Rights Agreement or are otherwise not freely tradable (if and when
issued) in accordance with applicable law, then the Registration Rights Agreement in respect of the
registration of the Warrant Shares shall remain in full force and effect.

     Section 10.9 Title and Subtitles. The titles and subtitles used in this Agreement are
used for the convenience of reference and are not to be considered in construing or interpreting
this Agreement.

     Section 10.10 Counterparts. This Agreement may be executed in multiple counterparts,
each of which may be executed by less than all of the parties and shall be deemed to be an original
instrument which shall be enforceable against the parties actually executing such counterparts and
all of which together shall constitute one and the same instrument.

     Section 10.11 Choice of Law. This Agreement shall be construed under the laws of the
State of New York.

     Section 10.12 Specific Enforcement, Consent to Jurisdiction.

          (a) The Company and the Investor acknowledge and agree that irreparable damage would occur in
the event that any of the provisions of this Agreement were not performed in accordance with their
specific terms or were otherwise breached. It is accordingly agreed that either party shall be
entitled to an injunction or injunctions to prevent or cure breaches of the provisions of this
Agreement by the other party and to enforce specifically the terms and provisions hereof or
thereof, this being in addition to any other remedy to which either party may be entitled by law or
equity.

          (b) Each of the Company and the Investor (i) hereby irrevocably submits to the jurisdiction of
the United States District Court and other courts of the United States sitting in the State of New
York for the purposes of any suit, action or proceeding arising out of or relating to this
Agreement and (ii) hereby waives, and agrees not to assert in any such suit, action or proceeding,
any claim that it is not personally subject to the jurisdiction of such court, that the suit,
action or proceeding is brought in an inconvenient forum or that the venue of the suit, action or
proceeding is improper. Each of the Company and the Investor consents to process being served in
any such suit, action or proceeding by mailing a copy thereof to such party at the address in
effect for notices to it under this Agreement and agrees that such service shall constitute good
and sufficient service of process and notice thereof. Nothing in this Section 10.12 shall affect
or limit any right to serve process in any other manner permitted by law.

     Section 10.13 Survival. The representations and warranties of the Company and the
Investor contained in Articles IV and V and the covenants contained in Article V and Article VI
shall survive the execution and delivery hereof and the Closing until the termination of this

- 29 -

 

Agreement, and the agreements and covenants set forth in Article VIII and Article IX of this
Agreement shall survive the execution and delivery hereof and the Closing hereunder.

     Section 10.14 Publicity. Except as otherwise required by applicable law or
regulation, or NASDAQ rule or judicial process, prior to the Closing, neither the Company nor the
Investor shall issue any press release or otherwise make any public statement or announcement with
respect to this Agreement or the transactions contemplated hereby or the existence of this
Agreement. In the event the Company is required by law, regulation, NASDAQ rule or judicial
process, based upon reasonable advice of the Company’s counsel, to issue a press release or
otherwise make a public statement or announcement with respect to this Agreement prior to the
Closing, the Company shall consult with the Investor on the form and substance of such press
release, statement or announcement. Promptly after the Closing, each party may issue a press
release or otherwise make a public statement or announcement with respect to this Agreement or the
transactions contemplated hereby or the existence of this Agreement; provided that, prior to
issuing any such press release, making any such public statement or announcement, the party wishing
to make such release, statement or announcement consults and cooperates in good faith with the
other party in order to formulate such press release, public statement or announcement in form and
substance reasonably acceptable to both parties.

     Section 10.15 Further Assurances. From and after the date of this Agreement, upon the
request of the Investor or the Company, each of the Company and the Investor shall execute and
deliver such instruments, documents and other writings as may be reasonably necessary or desirable
to confirm and carry out and to effectuate fully the intent and purposes of this Agreement.

[Remainder of this page intentionally left blank]

- 30 -

 

     IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be duly executed by their
respective authorized officer as of the date first written.

	 	 	 	 	 
	 	KINGSBRIDGE CAPITAL LIMITED

 	 
	 	By:  	/s/ Antony Gardner-Hillman
 	 
	 	 	Antony Gardner-Hillman 	 
	 	 	Director 	 
	 
	 	EPIX PHARMACEUTICALS, INC.

 	 
	 	By:  	/s/ Kim Cobleigh Drapkin
 	 
	 	 	Kim Cobleigh Drapkin 	 
	 	 	Chief Financial Officer 	 
	 

[Signature Page to Common Stock Purchase Agreement]

- 31 -

 

Exhibit A

Form of Registration Rights Agreement

 

 

Exhibit B

Form of Warrant

 

 

Exhibit C

Form of Draw Down Notice

Kingsbridge Capital Limited

Attention: Mr. Antony Gardner-Hillman

P.O. Box 1075

Elizabeth House

9 Castle Street

St. Helier

Jersey

JE42QP

Channel Islands

Facsimile: 011-44-1534-636-042

Email: admin@kingsbridgecap.com; and adamgurney@kingsbridgecap.com

Kingsbridge Corporate Services Limited

Kingsbridge House

New Abbey

Kilcullen, County Kildare

Republic of Ireland

Facsimile: 011-353-45-482-003

Email: adamgurney@kingsbridge.ie; and pwhelan@kingsbridge.ie

Stroock & Stroock & Lavan LLP

180 Maiden Lane

New York, NY 10038

Facsimile: (212) 806-5400

Attention: Keith M. Andruschak, Esq. – kandruschak@stroock.com

Reference is hereby made to that certain Common Stock Purchase Agreement dated as of July ___, 2008
(the “Agreement”) by and between EPIX Pharmaceuticals, Inc., a corporation organized and existing
under the laws of the State of Delaware (the “Company”), and Kingsbridge Capital Limited, an entity
organized and existing under the laws of the British Virgin Islands (the “Investor”). Capitalized
terms used and not otherwise defined herein shall have the meanings given such terms in the
Agreement.

In accordance with and pursuant to Section 3.1 of the Agreement, the Company hereby issues this
Draw Down Notice to the Investor pursuant to the terms set forth below.

Draw Down Amount: $                    ; and

First Trading Day of Draw Down Pricing Period:                     , 20[_].

Enclosed with this Draw Down Notice is an executed copy of the Officer’s Certificate described in
Section 3.1 of the Agreement, the base form of which is attached to such Agreement as Exhibit D.

 

 

Exhibit D

Officer’s Certificate

     I, [NAME OF OFFICER], do hereby certify to Kingsbridge Capital Limited (the
“Investor”), with respect to the common stock of EPIX Pharmaceuticals, Inc. (the
“Company”) issuable in connection with the Draw Down Notice, dated                      (the
“Notice”) attached hereto and delivered pursuant to Article III of the Common Stock
Purchase Agreement, dated July ___, 2008 (the “Agreement”), by and between the Company and
the Investor, as follows (capitalized terms used but undefined herein have the meanings given to
such terms in the Agreement):

     1. I am the duly elected [OFFICER] of the Company.

     2. The representations and warranties of the Company set forth in Article IV of the Agreement
are true and correct in all material respects as though made on and as of the date hereof (except
for such representations and warranties that are made as of a particular date).

     3. The Company has performed in all material respects all covenants and agreements to be
performed by the Company on or prior to the date hereof related to the Notice and has satisfied
each of the conditions to the obligation of the Investor set forth in Article VII of the Agreement.

     4. Assuming confirmation by the Investor of the representations and agreements contained in
Section 5.10 of the Agreement, the Shares issuable in respect of the Notice will be delivered
without restrictive legend via book entry through the Depositary Trust Company to an account
designated by the Investor.

     The undersigned has executed this Certificate this                      day of, 20[_].

	 	 	 	 	 
	 

	 	Name:	 	 
	 

	 	 	 	 
	 

	 	Title:exv10w2

Exhibit 10.2

EXECUTION VERSION

REGISTRATION RIGHTS AGREEMENT

     This REGISTRATION RIGHTS AGREEMENT (this “Agreement”), dated as of August 4, 2008, is
by and between EPIX Pharmaceuticals, Inc. (the “Company”) and KINGSBRIDGE CAPITAL LIMITED
(the “Investor”).

     WHEREAS, the Company and the Investor have entered into that certain Common Stock Purchase
Agreement, dated as of the date hereof (the “Purchase Agreement”), pursuant to which the
Company may issue, from time to time, to the Investor up to $50 million worth of shares of Common
Stock as provided for therein;

     WHEREAS, pursuant to the terms of, and in partial consideration for the Investor entering
into, the Purchase Agreement, the Company has issued to the Investor a warrant, exercisable from
time to time, in accordance with its terms, within five (5) years following the six-month
anniversary of the date of issuance (the “Warrant”) for the purchase of an aggregate of up
to 400,000 shares of Common Stock at a price specified in such Warrant;

     WHEREAS, pursuant to the terms of, and in partial consideration for, the Investor’s agreement
to enter into the Purchase Agreement, the Company has agreed to provide the Investor with certain
registration rights with respect to the Registrable Securities (as defined in the Purchase
Agreement) as set forth herein;

     NOW, THEREFORE, in consideration of the premises, the representations, warranties, covenants
and agreements contained herein, in the Warrant, and in the Purchase Agreement, and for other good
and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, intending
to be legally bound hereby, the parties hereto agree as follows (capitalized terms used herein and
not defined herein shall have the respective meanings ascribed to them in the Purchase Agreement):

ARTICLE I

REGISTRATION RIGHTS

     Section 1.1 Registration Statement.

          (a) Filing of the Registration Statement. Upon the terms and subject to the
conditions set forth in this Agreement, the Company shall file with the Commission within sixty
(60) calendar days after the Closing Date a registration statement on Form S-3 under the Securities
Act for the registration for the resale by the Investor of Registrable Securities in an amount not
to exceed 19.99% of the shares of Common Stock outstanding on the date hereof (the “Registration
Statement”), without reliance upon General Instruction I.B.6. thereof.

          (b) Effectiveness of the Registration Statement. The Company shall use commercially
reasonable efforts (i) to have the Registration Statement declared effective by the Commission as
soon as reasonably practicable, but in any event no later than one hundred eighty (180) calendar
days after the Closing Date and (ii) to ensure that the Registration Statement remains in effect
throughout the term of this Agreement as set forth in Section 4.2, subject to the terms and
conditions of this Agreement.

 

 

          (c) Regulatory Disapproval. The contemplated effective date for the Registration
Statement as described in Section 1.1(b) shall be extended without default or liquidated damages
hereunder or under the Purchase Agreement in the event that the Company’s failure to obtain the
effectiveness of the Registration Statement on a timely basis results from (i) the failure of the
Investor to timely provide the Company with information requested by the Company and necessary to
complete the Registration Statement in accordance with the requirements of the Securities Act or
(ii) the Commission’s disapproval of the structure of the transactions contemplated by the Purchase
Agreement, or (iii) events or circumstances that are not in any way attributable to the Company.
In the event of clause (ii) above, the parties agree to cooperate with one another in good faith to
arrive at a resolution acceptable to the Commission.

          (d) Failure to Maintain Effectiveness of Registration Statement. In the event the
Company fails to maintain the effectiveness of the Registration Statement (or the Prospectus)
throughout the period set forth in Section 4.2, other than temporary suspensions as set forth in
Section 1.1(e), and the Investor holds any Registrable Securities (other than Warrant Shares) at
any time during the period of such ineffectiveness (an “Ineffective Period”), and provided that
such failure to maintain effectiveness was within the reasonable control of the Company (for the
avoidance of doubt, the suspension of effectiveness of the Registration Statement as the result of
filing a post-effective amendment to the Registration Statement when required pursuant to Section
10(a)(3) under the Securities Act or Item 512(a)(1) of Regulation S-K shall be deemed not to be
within the reasonable control of the Company), the Company shall pay on demand to the Investor in
immediately available funds into an account designated by the Investor an amount equal to the
product of (i) the total number of Registrable Securities issued to the Investor under the Purchase
Agreement (which, for the avoidance of doubt, shall not include any Warrant Shares) and owned by
the Investor at any time during such Ineffective Period (and not otherwise sold, hypothecated or
transferred) and (ii) the result, if greater than zero, obtained by subtracting the VWAP on the
Trading Day immediately following the last day of such Ineffective Period from the VWAP on the
Trading Day immediately preceding the day on which any such Ineffective Period began; provided,
however, that (A) the foregoing payments shall not apply in respect of Registrable Securities (I)
that are otherwise freely tradable by the Investor, including pursuant to Rule 144 under the
Securities Act (as such Rule may be amended from time to time, “Rule 144”) or (II) if the Company
offers to repurchase from the Investor such Registrable Securities for a per share purchase price
equal to the VWAP on the Trading Day immediately preceding the day on which any such Ineffective
Period began and (B) unless otherwise required by any applicable federal and state securities laws,
the Company shall be under no obligation to supplement the Prospectus to reflect the issuance of
any Shares pursuant to a Draw Down at any time prior to the day following the Settlement Date with
respect to such Shares and that the failure to supplement the Prospectus prior to such time shall
not be deemed a failure to maintain the effectiveness of the Registration Statement (or Prospectus)
for purposes of this Agreement (including this Section 1.1(d)).

          (e) Deferral or Suspension During a Blackout Period. Notwithstanding the provisions
of Section 1.1(d), if in the good faith judgment of the Company, following consultation with legal
counsel, it would be detrimental to the Company or its stockholders for the Registration Statement
to be filed or for resales of Registrable Securities to be made pursuant to the Registration
Statement due to (i) the existence of a material development or potential material development
involving the Company that the Company would be obligated to disclose or incorporate by reference
in the Registration Statement and which the Company has not disclosed, or which disclosure would

-2-

 

be premature or otherwise inadvisable at such time or would have a Material Adverse Effect on
the Company or its stockholders, or (ii) a filing of a Company-initiated registration of any class
of its equity securities, which, in the good faith judgment of the Company, would adversely affect
or require premature disclosure of the filing of such Company-initiated registration (notice
thereof, a “Blackout Notice”), the Company shall have the right to (A) immediately defer
such filing for a period of not more than sixty (60) days beyond the date by which such
Registration Statement was otherwise required hereunder to be filed or (B) suspend use of such
Registration Statement for a period of not more than thirty (30) days (any such deferral or
suspension period, a “Blackout Period”). The Investor acknowledges that it would be
seriously detrimental to the Company and its stockholders for such Registration Statement to be
filed (or remain in effect) during a Blackout Period and therefore essential to defer such filing
(or suspend the use thereof) during such Blackout Period and agrees to cease any disposition of the
Registrable Securities during such Blackout Period. The Company may not utilize any of its rights
under this Section 1.1(e) to defer the filing of a Registration Statement (or suspend its
effectiveness) more than six (6) times in any twelve (12) month period. In the event that, within
fifteen (15) Trading Days following any Settlement Date, the Company gives a Blackout Notice to the
Investor and the VWAP on the Trading Day immediately preceding such Blackout Period (“Old
VWAP”) is greater than the VWAP on the first Trading Day following such Blackout Period that
the Investor may sell its Registrable Securities pursuant to an effective Registration Statement
(“New VWAP”), then the Company shall pay to the Investor, by wire transfer of immediately
available funds to an account designated by the Investor, the “Blackout Amount.” For the purposes
of this Agreement, Blackout Amount means a percentage equal to: (1) seventy-five percent (75%) if
such Blackout Notice is delivered prior to the fifth (5th) Trading Day following such Settlement
Date; (2) fifty percent (50%) if such Blackout Notice is delivered on or after the fifth (5th)
Trading Day following such Settlement Date, but prior to the tenth (10th) Trading Day following
such Settlement Date; (3) twenty-five percent (25%) if such Blackout Notice is delivered on or
after the tenth (10th) Trading Day following such Settlement Date, but prior to the fifteenth
(15th) Trading Day following such Settlement Date; and (4) zero percent (0%) thereafter of: the
product of (i) the number of Registrable Securities (other than Warrant Shares) purchased by the
Investor pursuant to the most recent Draw Down and actually held by the Investor immediately prior
to the Blackout Period and (ii) the result, if greater than zero, obtained by subtracting the New
VWAP from the Old VWAP; provided, however, that no Blackout Amount shall be payable in respect of
Registrable Securities (x) that are otherwise freely tradable to United States Persons by the
Investor, including under Rule 144, during the Blackout Period or (y) if the Company offers to
repurchase from the Investor such Registrable Securities for a per share purchase price equal to
the VWAP on the Trading Day immediately preceding the day on which any such Blackout Period began.
For any Blackout Period in respect of which a Blackout Amount becomes due and payable, rather than
paying the Blackout Amount, the Company may at its sole discretion, issue to the Investor shares of
Common Stock with an aggregate market value determined as of the first Trading Day following such
Blackout Period equal to the Blackout Amount (“Blackout Shares”).

          (f) Liquidated Damages. The Company and the Investor hereto acknowledge and agree
that the amounts payable under Sections 1.1(d) and 1.1(e) and the Blackout Shares deliverable under
Section 1.1(e) above shall constitute liquidated damages and not penalties. The parties further
acknowledge that (i) the amount of loss or damages likely to be incurred by the Investor is
incapable or is difficult to precisely estimate, (ii) the amounts specified in such subsections
bear a reasonable proportion and are not plainly or grossly disproportionate to the probable loss
likely to be incurred in connection with any failure by the Company to obtain or maintain the
effectiveness of the

-3-

 

Registration Statement, (iii) one of the reasons for the Company and the Investor reaching an
agreement as to such amounts was the uncertainty and cost of litigation regarding the question of
actual damages, and (iv) the Company and the Investor are sophisticated business parties and have
been represented by sophisticated and able legal and financial counsel and negotiated this
Agreement at arm’s length. The Investor agrees that, so long as the Company makes the payments or
deliveries provided for in Sections 1.1(d) or 1.1(e), as applicable, the Company’s failure to
maintain the effectiveness, deferral or suspension of the Registration Statement that triggered
such payments or deliveries shall not constitute a material breach or default of any obligation of
the Company to the Investor and such payments or deliveries shall constitute the Investor’s sole
remedies with respect thereto.

          (g) Additional Registration Statements. In the event and to the extent that the
Registration Statement fails to register a sufficient amount of Common Stock necessary for the
Company to issue and sell to the Investor and the Investor to purchase from the Company and re-sell
all of the Registrable Securities to be issued, sold and purchased under the Purchase Agreement and
the Warrant, the Company shall, upon a timetable mutually agreeable to both the Company and the
Investor, prepare and file with the Commission an additional registration statement or statements
in order to effectuate the purpose of this Agreement, the Purchase Agreement, and the Warrant.
Such delay in registering such Registrable Securities shall not be subject to the payments by the
Company of the amounts set forth in Section 1.1(e) nor shall such delay constitute a material
breach or default of the Company’s obligations to the Investor.

ARTICLE II

REGISTRATION PROCEDURES

     Section 2.1 Filings; Information. The Company shall effect the registration
with respect to the sale of the Registrable Securities by the Investor in accordance with the
intended methods of disposition thereof. Without limiting the foregoing, the Company in each such
case will do the following as expeditiously as is commercially reasonable, but in no event later
than the deadline, if any, prescribed therefor in this Agreement:

          (a) Subject to Section 1.1(e), the Company shall (i) prepare and file with the Commission the
Registration Statement; (ii) use commercially reasonable efforts to cause such filed Registration
Statement to become and to remain effective (pursuant to Rule 415 under the Securities Act or
otherwise); (iii) prepare and file with the Commission such amendments and supplements to the
Registration Statement and the Prospectus used in connection therewith as may be necessary to keep
such Registration Statement effective for the time period prescribed by Section 4.2 and in order to
effectuate the purpose of this Agreement, the Purchase Agreement, and the Warrant; and (iv) comply
in all material respects with the provisions of the Securities Act with respect to the disposition
of all securities covered by such Registration Statement during such period in accordance with the
intended methods of disposition by the Investor set forth in such Registration Statement; provided,
however, that the Investor shall be responsible for the delivery of the Prospectus to the Persons
to whom the Investor sells the Shares and the Warrant Shares, and the Investor agrees to dispose of
Registrable Securities in compliance with the plan of distribution described in the Registration
Statement and otherwise in compliance with applicable federal and state securities laws.

-4-

 

          (b) The Company shall deliver to the Investor and its counsel, in accordance with the notice
provisions of Section 4.8, such number of copies of the Registration Statement, each amendment and
supplement thereto (in each case including all exhibits thereto), the Prospectus (including each
preliminary prospectus) and such other documents or information as the Investor or counsel may
reasonably request in order to facilitate the disposition of the Registrable Securities, provided,
however, that to the extent reasonably practicable, such delivery may be accomplished via
electronic means.

          (c) After the filing of the Registration Statement, the Company shall promptly notify the
Investor of any stop order issued or, to the Knowledge of the Company, threatened by the Commission
in connection therewith and take all commercially reasonable actions required to prevent the entry
of such stop order or to remove it if entered.

          (d) The Company shall use commercially reasonable efforts to (i) register or qualify the sale
of the Registrable Securities by the Investor under such other securities or blue sky laws of each
jurisdiction in the United States as the Investor may reasonably (in light of its intended plan of
distribution) request, and (ii) cause the sale of the Registrable Securities by the Investor to be
registered with or approved by such other governmental agencies or authorities in the United States
as may be necessary by virtue of the business and operations of the Company and do any and all
other customary acts and things that may be reasonably necessary or advisable to enable the
Investor to consummate the disposition of the Registrable Securities; provided, however, that the
Company will not be required to qualify generally to do business in any jurisdiction where it would
not otherwise be required to qualify but for this Section 2.1(d), subject itself to taxation in any
such jurisdiction, consent or subject itself to general service of process in any such
jurisdiction, change any existing business practices, benefit plans or outstanding securities or
amend or otherwise modify the Charter or Bylaws.

          (e) The Company shall make available to the Investor (and will deliver to Investor’s counsel),
(i) subject to restrictions imposed by the United States federal government or any agency or
instrumentality thereof, copies of all public correspondence between the Commission and the Company
concerning the Registration Statement and will also make available for inspection by the Investor
and any attorney, accountant or other professional retained by the Investor (collectively, the
“Inspectors”), (ii) upon reasonable advance notice during normal business hours all
financial and other records, pertinent corporate documents and properties of the Company
(collectively, the “Records”) as shall be reasonably necessary to enable them to exercise
their due diligence responsibility, and cause the Company’s officers and employees to supply all
information reasonably requested by any Inspectors in connection with the Registration Statement;
provided, however, that (x) the Company shall not be obligated to disclose any portion of the
Records consisting of either (A) material non public information or (B) confidential information of
a third party and (y) any such Inspectors must agree in writing for the benefit of the Company not
to use or disclose any such Records except as provided in this Section 2.1(e). Records that the
Company determines, in good faith, to be confidential and that it notifies the Inspectors are
confidential shall not be disclosed by the Inspectors unless the disclosure or release of such
Records is requested or required pursuant to oral questions, interrogatories, requests for
information or documents or a subpoena or other order from a court of competent jurisdiction or
other judicial or governmental process; provided, however, that prior to any disclosure or release
pursuant to the immediately preceding clause, the Inspectors shall provide the Company with prompt
notice of any such request

-5-

 

or requirement so that the Company may seek an appropriate protective order or waive such
Inspectors’ obligation not to disclose such Records; and, provided, further, that if failing the
entry of a protective order or the waiver by the Company permitting the disclosure or release of
such Records, the Inspectors, upon advice of counsel, are compelled to disclose such Records, the
Inspectors may disclose that portion of the Records that counsel has advised the Inspectors that
the Inspectors are compelled to disclose; provided, however, that upon any such required
disclosure, such Inspector shall use his or her best efforts to obtain reasonable assurances that
confidential treatment will be afforded such information. The Investor agrees that information
obtained by it solely as a result of such inspections (not including any information obtained from
a third party who, insofar as is known to the Investor after reasonable inquiry, is not prohibited
from providing such information by a contractual, legal or fiduciary obligation to the Company)
shall be deemed confidential and shall not be used for any purposes other than as indicated above
or by it as the basis for any market transactions in the securities of the Company or its
affiliates unless and until such information is made generally available to the public. The
Investor further agrees that it will, upon learning that disclosure of such Records is sought in a
court of competent jurisdiction, give notice to the Company and allow the Company, at its expense,
to undertake appropriate action to prevent disclosure of the Records deemed confidential.

          (f) The Company shall otherwise comply in all material respects with all applicable rules and
regulations of the Commission, including, without limitation, compliance with applicable reporting
requirements under the Exchange Act.

          (g) The Company shall appoint (or shall have appointed) a transfer agent and registrar for all
of the Registrable Securities covered by such Registration Statement not later than the effective
date of such Registration Statement.

          (h) The Investor shall cooperate with the Company, as reasonably requested by the Company, in
connection with the preparation and filing of any Registration Statement hereunder. The Company
may require the Investor to promptly furnish in writing to the Company such information as may be
required in connection with such registration including, without limitation, all such information
as may be requested by the Commission, the NASDAQ Stock Market or FINRA or any state securities
commission and all such information regarding the Investor, the Registrable Securities held by the
Investor and the intended method of disposition of the Registrable Securities. The Investor agrees
to provide such information requested in connection with such registration within five (5) business
days after receiving such written request and the Company shall not be responsible for, or incur
any penalties under this Agreement with respect to, any delays in obtaining or maintaining the
effectiveness of the Registration Statement caused by the Investor’s failure to timely provide such
information.

          (i) Upon receipt of a Blackout Notice from the Company, the Investor shall immediately
discontinue disposition of Registrable Securities pursuant to the Registration Statement covering
such Registrable Securities until (i) the Company advises the Investor that the Blackout Period has
terminated and (ii) the Investor receives copies of a supplemented or amended prospectus, if
necessary. If so directed by the Company, the Investor will deliver to the Company (at the expense
of the Company) or destroy (and deliver to the Company a certificate of destruction) all copies in
the Investor’s possession (other than a limited number of file copies) of the prospectus covering
such Registrable Securities that is current at the time of receipt of such notice.

-6-

 

     Section 2.2 Registration Expenses. Except as set forth in Section 10.1 of the
Purchase Agreement, the Company shall pay all registration expenses incurred in connection with the
Registration Statement (the “Registration Expenses”), including, without limitation:
(a) all registration, filing, securities exchange listing and fees required by the NASDAQ Stock
Market, (b) all registration, filing, qualification and other fees and expenses of compliance with
securities or blue sky laws (including reasonable fees and disbursements of counsel in connection
with blue sky qualifications of the Registrable Securities), (c) all of the Company’s word
processing, duplicating, printing, messenger and delivery expenses, (d) the Company’s internal
expenses (including, without limitation, all salaries and expenses of its officers and employees
performing legal or accounting duties), (e) the fees and expenses incurred by the Company in
connection with the listing of the Registrable Securities, (f) reasonable fees and disbursements of
counsel for the Company and customary fees and expenses for independent certified public
accountants retained by the Company (including the expenses of any special audits or comfort
letters or costs associated with the delivery by independent certified public accountants of such
special audit(s) or comfort letter(s), (g) the fees and expenses of any special experts retained by
the Company in connection with such registration and amendments and supplements to the Registration
Statement and Prospectus, and (h) premiums and other costs of the Company for policies of insurance
against liabilities of the Company arising out of any public offering of the Registrable Securities
being registered, to the extent that the Company in its discretion elects to obtain and maintain
such insurance. Any fees and disbursements of underwriters, broker-dealers or investment bankers,
including without limitation underwriting fees, discounts, transfer taxes or commissions, and any
other fees or expenses (including legal fees and expenses) if any, attributable to the sale of
Registrable Securities, shall be payable by each holder of Registrable Securities pro rata on the
basis of the number of Registrable Securities of each such holder that are included in a
registration under this Agreement.

ARTICLE III

INDEMNIFICATION

     Section 3.1 Indemnification. The Company agrees to indemnify and hold
harmless the Investor, its partners, affiliates, officers, directors, employees and duly authorized
agents, and each Person or entity, if any, who controls the Investor within the meaning of
Section 15 of the Securities Act or Section 20 of the Exchange Act, together with the partners,
affiliates, officers, directors, employees and duly authorized agents of such controlling Person or
entity (collectively, the “Controlling Persons”), from and against any loss, claim, damage,
liability, costs and expenses (including, without limitation, reasonable attorneys’ fees and
disbursements and costs and expenses of investigating and defending any such claim) (collectively,
“Damages”), joint or several, and any action or proceeding in respect thereof to which the
Investor, its partners, affiliates, officers, directors, employees and duly authorized agents, and
any Controlling Person, may become subject under the Securities Act or otherwise, as incurred,
insofar as such Damages (or actions or proceedings in respect thereof) arise out of, or are based
upon, any untrue statement or alleged untrue statement of a material fact contained in any
Registration Statement, or in any preliminary prospectus, final prospectus, summary prospectus,
amendment or supplement relating to the Registrable Securities or arises out of, or are based upon,
any omission or alleged omission to state therein a material fact required to be stated therein or
necessary to make the statements therein under the circumstances not misleading, and shall
reimburse the Investor, its partners, affiliates, officers, directors, employees and duly
authorized agents, and each such Controlling Person, for any legal and

-7-

 

other expenses reasonably incurred by the Investor, its partners, affiliates, officers,
directors, employees and duly authorized agents, or any such Controlling Person, as incurred, in
investigating or defending or preparing to defend against any such Damages or actions or
proceedings; provided, however, that the Company shall not be liable to the extent that any such
Damages arise out of the Investor’s (or any other indemnified Person’s) failure to send or give a
copy of the final prospectus or supplement (as then amended or supplemented) to the persons
asserting an untrue statement or alleged untrue statement or omission or alleged omission at or
prior to the written confirmation of the sale of Registrable Securities to such person if such
statement or omission was corrected in such final prospectus or supplement; provided, further, that
the Company shall not be liable to the extent that any such Damages arise out of or are based upon
an untrue statement or alleged untrue statement or omission or alleged omission made in such
Registration Statement, or any such preliminary prospectus, final prospectus, summary prospectus,
amendment or supplement in reliance upon and in conformity with written information furnished to
the Company by or on behalf of the Investor or any other person who participates as an underwriter
in the offering or sale of such securities, in either case, specifically stating that it is for use
in the preparation thereof. In connection with any Registration Statement with respect to which
the Investor is participating, the Investor will indemnify and hold harmless, to the same extent
and in the same manner as set forth in the preceding paragraph, the Company, each of its partners,
affiliates, officers, directors, employees and duly authorized agents, and each person or entity,
if any, who controls the Company within the meaning of Section 15 of the Securities Act or Section
20 of the Exchange Act, together with the partners, affiliates, officers, directors, employees and
duly authorized agents of such controlling Person (each a “Company Indemnified Person”)
against any Damages to which any Company Indemnified Person may become subject under the Securities
Act, the Exchange Act or otherwise, insofar as such Damages arise out of or are based upon (a) any
untrue statement or alleged untrue statement of a material fact contained in any Registration
Statement, or in any preliminary prospectus, final prospectus, summary prospectus, amendment or
supplement relating to the Registrable Securities or arise out of, or are based upon, any omission
or alleged omission to state therein a material fact required to be stated therein or necessary to
make the statements therein under the circumstances not misleading to the extent that such
violation occurs in reliance upon and in conformity with written information furnished to the
Company by the Investor or on behalf of the Investor expressly for use in connection with such
Registration Statement, or (b) any failure by the Investor to comply with prospectus delivery
requirements of the Securities Act, the Exchange Act or any other law or legal requirement
applicable to sales under the Registration Statement.

     Section 3.2 Conduct of Indemnification Proceedings. All claims for
indemnification under Section 3.1 shall be asserted and resolved in accordance with the provisions
of Section 9.2 and 9.3 of the Purchase Agreement.

     Section 3.3 Additional Indemnification. Indemnification similar to that
specified in the preceding paragraphs of this Article III (with appropriate modifications) shall be
given by the Company and the Investor with respect to any required registration or other
qualification of securities under any federal or state law or regulation of any governmental
authority other than the Securities Act. The provisions of this Article III shall be in addition
to any other rights to indemnification, contribution or other remedies which an Indemnified Party
or a Company Indemnified Person may have pursuant to law, equity, contract or otherwise.

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To the extent that any indemnification provided for herein is prohibited or limited by law, the
indemnifying party will make the maximum contribution with respect to any amounts for which it
would otherwise be liable under this Article III to the fullest extent permitted by law. However,
(a) no contribution will be made under circumstances where the maker of such contribution would not
have been required to indemnify the indemnified party under the fault standards set forth in this
Article III, (b) if the Investor is guilty of fraudulent misrepresentation (within the meaning of
Section 11(f) of the Securities Act) the Investor will not be entitled to contribution from any
Person who is not guilty of such fraudulent misrepresentation, and (c) contribution (together with
any indemnification obligations under this Agreement) by the Investor will be limited in amount to
the proceeds received by the Investor from sales of Registrable Securities.

ARTICLE IV

MISCELLANEOUS

     Section 4.1 No Outstanding Registration Rights. Except for the Securities
Purchase Agreement dated as of November 15, 2007, by and among the Company and the purchasers
listed on Exhibit A thereto and except as otherwise disclosed in accordance with the Purchase
Agreement or in the Commission Documents, the Company represents and warrants to the Investor that
there is not in effect on the date hereof any agreement by the Company pursuant to which any
holders of securities of the Company have a right to cause the Company to register or qualify such
securities under the Securities Act or any securities or blue sky laws of any jurisdiction.

     Section 4.2 Term. The registration rights provided to the holders of
Registrable Securities hereunder, and the Company’s obligation to keep the Registration Statement
effective, shall terminate at the earlier of (a) such time that is two years following the
termination of the Purchase Agreement, (b) such time as all Registrable Securities have been issued
and have ceased to be Registrable Securities, or (c) upon the consummation of an “Excluded
Merger or Sale” as defined in the Warrant or an event described in the last sentence of
Section 6(d) or Section 6(e) of the Warrant. Notwithstanding the foregoing, Article III,
Section 4.7, Section 4.8, Section 4.9, Section 4.10, and Section 4.13 shall survive the termination
of this Agreement.

     Section 4.3 Rule 144. The Company will, at its expense, promptly take such
action as holders of Registrable Securities may reasonably request to enable such holders of
Registrable Securities to sell Registrable Securities without registration under the Securities Act
within the limitation of the exemptions provided by (a) Rule 144 under the Securities Act
(“Rule 144”), as such Rule may be amended from time to time, or (b) any similar rule or
regulation hereafter adopted by the Commission. If at any time the Company is not required to file
reports under Section 13 or 15(d) of the Exchange Act, it will, at its expense, forthwith upon the
written request of any holder of Registrable Securities, make available adequate current public
information with respect to the Company within the meaning of Rule 144(c)(2) or such other
information as necessary to permit sales pursuant to Rule 144. Upon the request of the Investor,
the Company will deliver to the Investor a written statement, signed by the Company’s principal
financial officer, as to whether it has complied with such requirements.

     Section 4.4 Certificate. The Company will, at its expense, forthwith upon the
request of any holder of Registrable Securities, deliver to such holder a certificate, signed by
the Company’s

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principal financial officer, stating (a) the Company’s name, address and telephone number
(including area code), (b) the Company’s Internal Revenue Service identification number, (c) the
Company’s Commission file number, (d) the number of shares of each class of capital stock
outstanding as shown by the most recent report or statement published by the Company, and (e)
whether the Company has filed the reports required to be filed under the Exchange Act for a period
of at least ninety (90) days prior to the date of such certificate and in addition has filed the
most recent annual report required to be filed thereunder.

     Section 4.5 Amendment And Modification. Any provision of this Agreement may
be waived, provided that such waiver is set forth in a writing executed by the Company and the
holder(s) of the majority of then-outstanding Registrable Securities. The provisions of this
Agreement, including the provisions of this sentence, may be amended, modified or supplemented, and
waivers or consents to departures from the provisions hereof may be given, with the written consent
of the Company and the holder(s) of the majority of then-outstanding Registrable Securities. No
course of dealing between or among any Person having any interest in this Agreement will be deemed
effective to modify, amend or discharge any part of this Agreement or any rights or obligations of
any person under or by reason of this Agreement.

     Section 4.6 Successors and Assigns; Entire Agreement. This Agreement and all
of the provisions hereof shall be binding upon and inure to the benefit of the parties hereto and
their respective successors and permitted assigns. The Company may assign this Agreement at any
time in connection with a sale or acquisition of the Company, whether by merger, consolidation,
sale of all or substantially all of the Company’s assets, or similar transaction, without the
consent of the Investor, provided that the successor or acquiring Person or entity agrees in
writing to assume all of the Company’s rights and obligations under this Agreement. Investor may
assign its rights and obligations under this Agreement only with the prior written consent of the
Company, and any purported assignment by the Investor absent the Company’s consent shall be null
and void. This Agreement, together with the Purchase Agreement and the Warrant sets forth the
entire agreement and understanding between the parties as to the subject matter hereof and merges
and supersedes all prior discussions, agreements and understandings of any and every nature among
them.

     Section 4.7 Severability. If any provision of this Agreement becomes or is
declared by a court of competent jurisdiction to be illegal, unenforceable or void, this Agreement
shall continue in full force and effect without said provision; provided that, if the severance of
such provision materially changes the economic benefits of this Agreement to either party as such
benefits are anticipated as of the date hereof, then such party may terminate this Agreement on
five (5) business days prior written notice to the other party. In such event, the Purchase
Agreement will terminate simultaneously with the termination of this Agreement.

     Section 4.8 Notices. All notices, demands, requests, consents, approvals, and
other communications required or permitted hereunder shall be given in accordance with Section 10.4
of the Purchase Agreement.

     Section 4.9 Governing Law; Dispute Resolution. This Agreement shall be
construed under the laws of the State of New York.

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     Section 4.10 Headings. The headings in this Agreement are for convenience of
reference only and shall not constitute a part of this Agreement, nor shall they affect their
meaning, construction or effect.

     Section 4.11 Counterparts. This Agreement may be executed in multiple
counterparts, each of which shall be deemed to be an original instrument and all of which together
shall constitute one and the same instrument.

     Section 4.12 Further Assurances. Each party shall cooperate and take such
action as may be reasonably requested by another party in order to carry out the provisions and
purposes of this Agreement and the transactions contemplated hereby.

     Section 4.13 Absence of Presumption. This Agreement shall be construed
without regard to any presumption or rule requiring construction or interpretation against the
party drafting or causing any instrument to be drafted.

[Remainder of this page intentionally left blank]

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IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed by the

undersigned, thereunto duly authorized, as of the date first set forth above.

	 	 	 	 	 
	 	KINGSBRIDGE CAPITAL LIMITED

 	 
	 	By:  	/s/ Antony Gardner-Hillman
 	 
	 	 	Antony Gardner-Hillman 	 
	 	 	Director 	 
	 
	 	EPIX PHARMACEUTICALS, INC.

 	 
	 	By:  	/s/ Kim Cobleigh Drapkin
 	 
	 	 	Kim Cobleigh Drapkin 	 
	 	 	Chief Financial Officer 	 
	 

[Signature Page to Registration Rights Agreement]

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