Document:

Key Employee Change-in-Control Severance Benefits Plan

 Exhibit 10.8 
 AVEO PHARMACEUTICALS, INC. 
 KEY EMPLOYEE CHANGE IN
CONTROL SEVERANCE BENEFITS PLAN 
 SECTION 1. INTRODUCTION 
 The Key Employee Change in Control Severance Benefits Plan (the “Plan”) is designed to provide separation pay and benefits to
certain eligible employees of AVEO Pharmaceuticals, Inc. (“the “Company”) whose employment is involuntarily terminated without cause or voluntarily terminated for good reason as set forth in this Plan. 
 SECTION 2. DEFINITIONS 
 For
purposes of this Plan, the following terms shall have the meanings set forth below: 
 (a) “BASE SALARY” means the
annual base salary for an Eligible Employee as in effect on the Change in Control Date, or as increased thereafter. 
 (b) “BOARD” means the Board of Directors of the Company. 
 (c) “CAUSE” means conduct
involving one or more of the following: (i) the conviction of the Eligible Employee of, or, plea of guilty or nolo contendere to, any crime involving dishonesty or any felony; (ii) the willful misconduct by the Eligible Employee resulting
in material harm to the Company; (iii) fraud, embezzlement, theft or dishonesty by the Eligible Employee against the Company resulting in material harm to the Company; (iv) the repeated and continuing failure of the Eligible Employee to
follow the proper and lawful directions of the Company’s Chief Executive Officer or the Board after a written demand is delivered to the Eligible Employee that specifically identifies the manner in which the Chief Executive Officer or the Board
believes that the Employee has failed to follow such instructions; (v) the Eligible Employee’s current alcohol or prescription drug abuse affecting work performance, or current illegal use of drugs regardless of the effect on work
performance; (vi) material violation of the Company’s code of conduct by the Eligible Employee that causes harm to the Company; or (vii) violation of any applicable written proprietary information,
confidentiality, non-competition and/or non-solicitation agreements with the Company. 
 (d) “CHANGE IN
CONTROL” means the occurrence of any of the events set forth in subsections (A) or (B) below, provided that such event(s) constitute (i) a change in the ownership of the Company (as defined in Treasury Regulation
Section 1.409A-3(i)(5)(v)), (ii) a change in effective control of the Company (as defined in Treasury Regulation Section 1.409A-3(i)(5)(vi)), or (iii) a change in the ownership of a substantial portion of the assets of the
Company (as defined in Treasury Regulation Section 1.409A-3(i)(5)(vii)): 
 (A) when a person, entity or group (within the
meaning of Section 13(d)(3) or 14(d)(2) of the Securities Exchange Act of 1934, a amended) acquires beneficial ownership of the Company’s capital stock equal to 50% or more of either: (X) the then-outstanding shares of the
Company’s common stock (the “Outstanding Company Common Stock”) or (Y) the combined voting power of the Company’s then-outstanding securities entitled to vote generally in the election of directors (the “Outstanding
Company Voting Securities”) provided, however, that for purposes of this subsection (A), the following acquisitions of securities shall not constitute a Change in Control: (1) any acquisition of securities directly from the Company
(excluding an acquisition of securities pursuant to the exercise, conversion or exchange of any security exercisable for, convertible into or exchangeable for common stock or voting securities of the Company, unless the Person exercising, converting
or exchanging such security acquired such security directly from the Company or an underwriter or agent of the Company) or (2) any acquisition of securities by the Company; or 

 (B) upon the consummation by the Company of a reorganization, merger, consolidation,
statutory share exchange or a sale or other disposition of all or substantially all of the assets of the Company in one or a series of transactions (a “Business Combination”), provided that, in each case, the persons who were the
Company’s beneficial owners of the Outstanding Company Common Stock and Outstanding Company Voting Securities immediately prior to such Business Combination do not beneficially own, directly or indirectly, more than 50% of the then-outstanding
shares of common stock and the combined voting power of the then-outstanding securities entitled to vote generally in the election of directors, respectively, of the resulting or acquiring corporation in such Business Combination (which shall
include, without limitation, a corporation which as a result of such transaction owns the Company or substantially all of the Company’s assets either directly or through one or more subsidiaries) in substantially the same proportions as their
ownership, immediately prior to such Business Combination, of the Outstanding Company Common Stock and Outstanding Company Voting Securities, respectively; or 
 (C) such time as the Continuing Directors (as defined below) do not constitute a majority of the Board (or, if applicable, the Board of Directors of a successor corporation to the Company), where the term
“Continuing Director” means at any date a member of the Board (i) who was a member of the Board on the effective date of this Plan, or (ii) who was nominated or elected subsequent to such date by at least a majority of the
directors who were Continuing Directors at the time of such nomination or election or whose election to the Board was recommended or endorsed by at least a majority of the directors who were Continuing Directors at the time of such nomination or
election; provided, however, that there shall be excluded from this clause (ii) any individual whose initial assumption of office occurred as a result of an actual or threatened election contest with respect to the election or
removal of directors or other actual or threatened solicitation of proxies or consents, by or on behalf of a person other than the Board. 
 (e) “CHANGE IN CONTROL DATE” means the first date on which a Change in Control occurs. 
 (f) “DISABILITY” means (i) the Eligible Employee is unable to engage in any substantial gainful activity by reason of any medically determinable physical or mental impairment that can
be expected to result in death or can be expected to last for a continuous period of not less than twelve (12) months or (ii) the Eligible Employee is, by reason of any medically determinable physical or mental impairment that can be
expected to result in death or can be expected to last for a continuous period of not less than twelve (12) months, receiving income replacement benefits for a period of not less than three (3) months under an accident and health plan
covering employees of the Company; provided that in each case, the Eligible Employee’s physical or mental impairment shall be determined by an independent qualified physician mutually acceptable to the Company and the Eligible Employee (or his
personal representative) or, if the Company and the Eligible Employee (or such representative) are unable to agree on an independent qualified physician, as determined by a panel of three physicians, one designated by the Company, one designated by
the Eligible Employee (or his personal representative) and one designated by the two physicians so designated. 
 (g)
“INVOLUNTARY TERMINATION WITHOUT CAUSE” means an Eligible Employee’s dismissal or discharge by the Company (or, if applicable, by any successor entity) for a reason other than Cause. The termination of employment will not be deemed to
be an “Involuntary Termination Without Cause” if such termination occurs as a result of the Eligible Employee’s voluntary resignation without Good Reason, death or Disability. 
 (i) “MANAGEMENT TEAM” shall include any executive officer, senior vice-president and vice-president of the Company and other
employees of the Company nominated by the Chief Executive Officer and ratified by the Compensation Committee. 
 (j)
“QUALIFYING TERMINATION” means that an Eligible Employee’s employment terminates due to an Involuntary Termination Without Cause or a Voluntary Termination for Good Reason, in either case, within eighteen (18) months following a
Change in Control Date. 
 (k) “SECTION 16 OFFICER” means an executive officer of the Company, other than the Chief
Executive Officer, Chief Financial Officer, Chief Business Officer and Chief Medical Officer, who is considered to an “officer” of the Company within the meaning of Rule 16a-1(f) under the Securities Exchange Act of 1934, as amended and
“executive Officer” of the Company within the meaning of Rule 3b-7 under the Securities Exchange Act of 1934, as amended. 

 (l) “VOLUNTARY TERMINATION FOR GOOD REASON” means any action by the Company
without the Eligible Employee’s prior consent which results in he or she voluntarily terminating his or her employment with the Company (or, if applicable, with any successor entity) after any of the following are undertaken by the Company (or,
if applicable, by any successor entity) without such Eligible Employee’s express consent, provided, however, that a termination for Good Reason can only occur if (i) the Eligible Employee has given the Company a written notice of
termination indicating the existence of a condition giving rise to Good Reason and the Company has not cured the condition giving rise to Good Reason within thirty (30) days after receipt of such notice of termination, and (ii) such notice
of termination is given within ninety (90) days after the initial occurrence of the condition giving rise to Good Reason and further provided that a termination for Good Reason shall occur no more than one hundred eighty (180) days after
the initial occurrence of the condition giving rise to Good Reason: (A) any requirement by the Company that the Eligible Employee perform his or her principal duties outside a radius of 50 miles from the Company’s Cambridge,
Massachusetts location, (B) any material diminution in the Eligible duties, responsibilities or authority; or (C) a material reduction in the Eligible Employee’s base salary (unless such reduction is effected in connection with a
general and proportionate reduction of compensation for all employees of his or her level). 
 SECTION 3. ELIGIBILITY AND PARTICIPATION

 An individual is deemed an “Eligible Employee” and, therefore, eligible to participate in the Plan if he or she is a
member of the Company’s Management Team at the time of such individual’s termination of employment with the Company, and such employment terminates due to an event which constitutes a Qualifying Termination. 
 SECTION 4. BENEFITS 
 Eligible
Employees are eligible to receive the following benefits on the following conditions: 
 (a) SALARY AND BONUS PAYOUT.
Commencing in the first month following the month of a Qualifying Termination and the Release set forth in Section (f) below becoming binding on the Eligible Employee, Eligible Employee will be paid in periodic installments consistent with the
Company’s payroll procedures as then in effect and continuing for a number of months equal to the product of the Eligible Employee’s “Severance Multiple” (as set forth below) times twelve (12), a total sum equal to:
(i) Severance Multiple times the Eligible Employee’s Base Salary; (ii) the Eligible Employee’s Severance Multiple times his/her target bonus on the date of the Qualifying Termination; and (iii) the Eligible Employee’s
target bonus on the date of termination multiplied by a fraction, the numerator of which shall equal the number of days the Eligible Employee was employed by the Company during the Company fiscal year in which the termination occurs and the
denominator of which shall equal 365. 
 Severance Multiple shall be based on the following: 
  

					
	 Chief Executive Officer
	  	—  	  	1.5
			
	 Chief Financial Officer, Chief Business Officer, Chief Medical Officer, Section 16 Officer, and any other Eligible
Employee nominated by the CEO and ratified by the Compensation Committee
	  	—  	  	1.0
			
	 Senior Vice Presidents, Vice Presidents and other Eligible Employees nominated by CEO and ratified by Compensation Committee,
other than those considered Section 16 Officers
	  	—  	  	0.5

 (b) HEALTH BENEFITS. Provided the Eligible Employee timely elects continued coverage
under federal COBRA law, the Company shall pay, on the Eligible Employee’s behalf, the portion of premiums for the type of group health insurance coverage, including coverage for his or her eligible dependents, that the Company paid prior to
his or her termination of employment for a period following his or her Qualifying Termination based on the Eligible Employee’s level as follows: 
  

					
	 Chief Executive Officer
	  	—  	  	18 months
			
	 Chief Financial Officer, Chief Business Officer, Chief Medical Officer, Section 16 Officer, and any other Eligible
Employee nominated by the CEO and ratified by the Compensation Committee
	  	—  	  	12 months
			
	 Senior Vice Presidents, Vice Presidents and other Eligible Employees nominated by CEO and ratified by Compensation Committee,
other than those considered Section 16 Officers
	  	—  	  	6 months

 provided, however, that the Company will pay such premiums for the Eligible Employee and his/her
eligible dependents only for coverage for which such individual and those dependents were enrolled immediately prior to the Qualifying Termination. The Eligible Employee shall continue to be required to pay that portion of the premium of such group
health insurance coverage, including coverage for his/her eligible dependents that he/she had been required to pay as an active employee immediately prior to the Qualifying Termination of employment (subject to change). For the balance of the period
that an Eligible Employee is eligible to receive coverage under federal COBRA law, the Eligible Employee shall be eligible to maintain coverage for himself/herself and his/her eligible dependents at the Eligible Employee’s own expense in
accordance with applicable law. 
 (c) EQUITY ACCELERATION. In addition to any other rights that Eligible Employees may have
with respect to the acceleration of the vesting of any stock options or restricted stock awards (“Awards”) granted to such Eligible Employees pursuant to the Company’s 2002 Stock Incentive Plan, as amended (the “2002 Stock
Incentive Plan”), or any successor plan, including without limitation those certain change in control related acceleration rights (upon a termination without cause) approved by the Board on December 11, 2007, and notwithstanding any
provision to the contrary contained in the 2002 Stock Incentive Plan, the instrument evidencing any Award or any other agreement between an Eligible Employee and the Company, each such Award shall be immediately exercisable in full and/or free of
all restrictions on repurchase, as the case may be, if the Eligible Employee’s employment with the Company or the acquiring or succeeding corporation is terminated as a result of a Qualifying Termination. 
 (d) EARNED BUT UNPAID BENEFITS. As of the Qualifying Termination date an Eligible Employee will also be eligible to receive any earned
but unpaid benefits including salary earned but unpaid, the annual bonus for the most recently completed financial year and payment for unused accrued vacation. 
 (e) RELEASE. To receive benefits under this Plan, an Eligible Employee must execute after the Qualifying
Termination a release of claims in favor of the Company within thirty (30) days following the Eligible Employee’s date of termination, in the form attached to this Plan as Exhibit A and such release must become effective
in accordance with its terms (the “Release”). Notwithstanding the foregoing, if the 30th day following the Eligible Employee’s date of termination occurs in the calendar year following the Eligible Employee’s termination, then the payments and benefits will commence no earlier than
January 1 of such subsequent calendar year. 
 (f) TERMINATION OF BENEFITS. Benefits under this Plan shall terminate
immediately if an Eligible Employee, at any time, violates any proprietary information, confidentiality, non-competition or non-solicitation obligation to the Company, or any other continuing obligation to the Company. 
 (g) NON-DUPLICATION OF BENEFITS. Eligible Employees are not eligible to receive benefits under this Plan more than one time and are not
eligible to receive benefits under any other Company change in control severance plan, arrangement or agreement. 
 (h) TAX
WITHHOLDING. Any payments that an Eligible Employee receives under this Plan shall be subject to all required tax withholding. 

 (i) DISTRIBUTIONS. The following rules shall apply with respect to distribution of the
payments and benefits, if any, to be provided to the Eligible Employee under this Section 4: 
 (A) It is intended that
each installment of the payments and benefits provided under Section 4 shall be treated as a separate “payment” for purposes of Section 409A of the U.S. Internal Revenue Code of 1986, as amended, and the guidance issued
thereunder (“Section 409A”). Neither the Company nor the Eligible Employee shall have the right to accelerate or defer the delivery of any such payments or benefits except to the extent specifically permitted or required by
Section 409A; 
 (B) If, as of the date of the “separation from service” of the Eligible Employee from the
Company, the Eligible Employee is not a “specified employee” (each within the meaning of Section 409A), then each installment of the payments and benefits shall be made on the dates and terms set forth in Section 4; and

 (C) If, as of the date of the “separation from service” of the Eligible Employee from the Company, the Eligible
Employee is a “specified employee” (each, for purposes of this Agreement, within the meaning of Section 409A), then: 
 (x) Each installment of the payments and benefits due under Section 4 that, in accordance with the dates and terms set forth herein, will in all circumstances, regardless of when the separation from service occurs, be paid within the
Short-Term Deferral Period (as hereinafter defined) shall be treated as a short-term deferral within the meaning of Treasury Regulation Section 1.409A-1(b)(4) to the maximum extent permissible under Section 409A. For purposes of this
Agreement, the “Short-Term Deferral Period” means the period ending on the later of the 15th day of the third month following the end of the Eligible Employee’s tax year in which the Eligible Employee’s separation from service
occurs and the 15th day of the third month following the end of the Company’s tax year in which the Eligible Employee’s separation from service occurs; and 
 (y) Each installment of the payments and benefits due under Section 4 that is not paid within the Short-Term Deferral Period and that would, absent this subsection, be paid within the six-month
period following the “separation from service” of the Eligible Employee of the Company shall not be paid until the date that is six months and one day after such separation from service (or, if earlier, the death of the Eligible Employee),
with any such installments that are required to be delayed being accumulated during the six-month period and paid in a lump sum on the date that is six months and one day following the Eligible Employee’s separation from service and any
subsequent installments, if any, being paid in accordance with the dates and terms set forth herein; provided, however, that the preceding provisions of this sentence shall not apply to any installment of payments and benefits if and to the maximum
extent that that such installment is deemed to be paid under a separation pay plan that does not provide for a deferral of compensation by reason of the application of Treasury Regulation 1.409A-1(b)(9)(iii) (relating to separation pay upon an
involuntary separation from service) or Treasury Regulation 1.409A-1(b)(9)(v) (relating to reimbursements and certain other separation payments). Such payments shall bear interest at an annual rate equal to the prime rate as set forth in the Eastern
edition of the Wall Street Journal on the Date of Termination, from the Date of Termination to the date of payment. Any installments that qualify for the exception under Treasury Regulation Section 1.409A-1(b)(9)(iii) must be paid no later than
the last day of the second taxable year of the Eligible Employee following the taxable year of the Eligible Employee in which the separation from service occurs. 
 SECTION 5. OTHER TERMINATIONS 
 An otherwise Eligible Employee shall NOT be
eligible to receive benefits under this Plan if (i) the Eligible Employee’s employment terminates due to death, Disability or any other reason other than a Qualifying Termination; or (ii) an Eligible Employee’s employment is
terminated within thirty (30) days of his or her refusal to accept an offer of comparable employment by any successor to the Company (provided that “comparable employment” shall mean employment at a business office the location of
which is not violative of Section 2(g)(i), with duties and responsibilities not violative of Section 2(g)(ii) and with a reduction in such Eligible Employee’s base salary not violative of 2(g)(iii)). 

 SECTION 6. CLAIMS PROCEDURE 
 Ordinarily, severance benefits will be paid to an Eligible Employee without to having to file a claim or take any action other than signing the Release as provided in Section 4(f) of this Plan and,
where applicable, not revoking the Release during the applicable revocation period. If an Eligible Employee believes that he or she is entitled to severance benefits under the Plan that are not being paid, he or she may submit a written claim for
payment to the Company. Any claim for benefits shall be in writing, addressed to the Company and must be sufficient to notify the Company of the benefit claimed. If such claim is denied, the Company shall within a reasonable period of time provide a
written notice of denial. The notice will include the specific reasons for denial, the provisions of the Plan on which the denial is based, and the procedure for a review of the denied claim. Where appropriate, it will also include a description of
any additional material or information necessary to complete or perfect the claim and an explanation of why that material or information is necessary. Eligible Employees may request in writing a review of a claim denied by the Company and may review
pertinent documents and submit issues and comments in writing to the Company. The Company shall provide a written decision upon such request for review of a denied claim. The decision of the Company upon such review shall be final. 
 SECTION 7. MISCELLANEOUS 
 The
Company reserves the right to amend or terminate this Plan at any time; provided however, that this Plan may not be amended or terminated following the Change in Control Date; and further provided that Section 4(c) of this Plan shall not be
amended without the Eligible Employee’s consent unless the Board determines that the amendment, taking into account any other related action, would not materially adversely affect the Eligible Employee. This Plan shall be binding upon any
surviving entity resulting from a Change in Control and upon any other person who is a successor by merger, acquisition, consolidation or otherwise to the business formerly carried on by the Company without regard to whether or not such person
actively adopts or formally continues the Plan. The Plan shall be interpreted in accordance with the laws of the Commonwealth of Massachusetts. The Eligible Employee hereby irrevocably submits to and acknowledges and recognizes the jurisdiction of
the courts of the Commonwealth of Massachusetts, or if appropriate, a federal court located in Massachusetts (which courts, for purposes of the Plan, are the only courts of competent jurisdiction), over any suit, action or other proceeding
arising out of, under or in connection with the Plan or the subject matter hereof. 

 EXHIBIT A 
 RELEASE 
 Certain capitalized terms used in this
Release are defined in the Key Employee Change in Control Severance Plan (the “Plan”) which I have reviewed. 
 In
order to receive the benefits as set forth in the Plan, I acknowledge that I must enter into this Release and have it become binding upon me. 
 Except as otherwise set forth in this Release, I hereby release, acquit and forever discharge the Company, its parents and subsidiaries, and their officers, directors, agents, servants, employees,
shareholders, predecessor, successors, assigns and affiliates as well as its and their representatives, agents, insurers and reinsurers, and employee benefit programs (and the trustees, administrators, fiduciaries and insurers of such programs),
past, present and future (hereafter, the “Released Parties”) from any and all claims, charges, complaints, demands, actions, causes of action, suits, rights, debts, sums of money, costs, accounts, reckonings, covenants, contracts,
agreements, promises, doings, omissions, damages, executions, obligations, liabilities, and expenses (including attorneys’ fees and costs), of every kind and nature which I ever had or now have against the Released Parties, including, but not
limited to, those claims arising out of my employment with and/or separation from the Company, including, but not limited to, all claims under Title VII of the Civil Rights Act of 1964, 42 U.S.C. § 2000e et seq., the Age
Discrimination in Employment Act, 29 U.S.C. § 621 et seq. (“ADEA”), the Americans With Disabilities Act of 1990, 42 U.S.C. § 12101 et seq., the Family and Medical Leave Act, 29 U.S.C. § 2601
et seq., the Worker Adjustment and Retraining Notification Act (“WARN”), 29 U.S.C. § 2101 et seq., Section 806 of the Corporate and Criminal Fraud Accountability Act of 2002, 18 U.S.C. § 1514(A),
the Rehabilitation Act of 1973, 29 U.S.C. § 701 et seq., Executive Order 11246, Executive Order 11141, the Fair Credit Reporting Act, 15 U.S.C. § 1681 et seq., the Employee Retirement Income Security Act of 1974
(“ERISA”), 29 U.S.C. § 1001 et seq., the Massachusetts Fair Employment Practices Act., M.G.L. c. 151B, § 1 et seq., the Massachusetts Civil Rights Act, M.G.L. c. 12, §§ 11H and 11I, the
Massachusetts Equal Rights Act, M.G.L. c. 93, § 102 and M.G.L. c. 214, § 1C, the Massachusetts Labor and Industries Act, M.G.L. c. 149, § 1 et seq., the Massachusetts Privacy Act, M.G.L. c. 214, § 1B, and the
Massachusetts Maternity Leave Act, M.G.L. c. 149, § 105D, all as amended; all common law claims including, but not limited to, actions in tort, defamation and breach of contract; all claims to any non-vested ownership interest in the Company,
contractual or otherwise, including, but not limited to, claims to stock or stock options; and any claim or damage arising out of my employment with or separation from the Company (including a claim for retaliation) under any common law theory or
any federal, state or local statute or ordinance not expressly referenced above; provided, however, that nothing in this Agreement prevents me from filing, cooperating with, or participating in any proceeding before the Equal Employment Opportunity
Commission or a state Fair Employment Practices Agency (except that I acknowledge that I may not be able to recover any monetary benefits in connection with any such claim, charge or proceeding); provided, further, that nothing in this paragraph
shall be construed in any way to release the Company from its obligation to indemnify me from any third party action brought against me based on my employment with the Company, pursuant to any applicable agreement or applicable law or to reduce or
eliminate any coverage I may have under the Company’s director and officer liability policy, if any. 
 I understand
and agree that, as a condition for payment to me of the Plan benefits, I shall not make any false, disparaging or derogatory statements to any media outlet, industry group, financial institution or current or former employee, consultant, client or
customer of the Company regarding the Company or any of its directors, officers, employees, agents or representatives or about the Company’s business affairs and financial condition; provided, however, that nothing herein shall
prevent me from making truthful disclosures to any governmental entity or in any litigation or arbitration. 
 I confirm that I
have returned to the Company all keys, files, records (and copies thereof), equipment (including, but not limited to, computer hardware, software and printers, wireless handheld devices, cellular phones, pagers, etc.), Company identification,
Company vehicles and any other Company-owned property in my possession or control and have left intact all electronic Company documents, including but not limited to, those that I developed or helped develop during my employment. I further confirm
that I have cancelled all accounts for my benefit, if any, in the Company’s name, including but not limited to, credit cards, telephone charge cards, cellular phone and/or pager accounts and computer accounts. 

 I acknowledge that I am knowingly and voluntarily waiving and releasing any rights I
may have under ADEA. I also acknowledge that the consideration given under the Plan for the waiver and release in the preceding paragraph hereof is in addition to anything of value to which I was already entitled. I further acknowledge that I
have been advised by this writing, as required by the ADEA, that: (A) my waiver and release do not apply to any rights or claims that may arise on or after the date I execute this Release; (B) I should consult with an attorney prior
to executing this Release; (C) I have been given more than twenty-one (21) days to consider this Release (although I may choose to voluntarily execute this Release earlier); (D) I have seven (7) days following my execution
of this Release to revoke the Release by notifying the Company; and (E) this Release shall not be effective until the date upon which the revocation period has expired, which shall be the eighth day after this Release is executed by me,
provided I have not timely revoked. 
  

			
	 Name:
	 	 
		
	Signature:	 	  

		
	Date:Amended and Restated Employment Agreement, Tuan Ha-Ngoc

 Exhibit 10.9 
 Amended and Restated 
 EMPLOYMENT AGREEMENT

 THIS AMENDED AND RESTATED EMPLOYMENT AGREEMENT (“Agreement”) is entered into as of the 19th day of December,
2008, by and among AVEO Pharmaceuticals, Inc. (f/k/a GenPath Pharmaceuticals, Inc.), a Delaware corporation (“Employer”), and Tuan Ha-Ngoc (“Employee”). 
 WITNESSETH: 
 WHEREAS, Employee and Employer entered into
that certain Employment Agreement dated as of June 17, 2002 (the “Original Employment Agreement”) outlining the terms of the Employee’s employment as President and Chief Executive Officer of the Employer; and ; 
 WHEREAS, Employee and Employer desire to amend and restate the Original Employment Agreement as follows. 
 NOW, THEREFORE, in consideration of the mutual covenants and promises contained herein, and other good and valuable consideration, the
receipt of which is hereby acknowledged, the parties agree as follows: 
 1. Employment. Employer hereby employs Employee
as its President and Chief Executive Officer, and Employee hereby accepts such employment by Employer upon the terms and conditions herein set forth. On June 17, 2002, Employee was elected as a director of Employer. Employee will report to the
Board of Directors of the Employer (the “Board”). 
 2. Term. The term of the Agreement commenced on
June 17, 2002 and will continue unless terminated pursuant to Section 5. Notwithstanding any such termination, the provisions of Sections 5(b), 5(c), 5(d), and Exhibits A, B, and C hereto shall survive in accordance with their
express terms. 

 3. Duties. Employee will, during the term of his employment hereunder: 
 (a) execute all duties attendant to the President and Chief Executive Officer of Employer and have all lawful powers
attendant to such position including the supervision, direction and control over the business and affairs of the corporation and its employees; 
 (b) faithfully and diligently do and perform all such acts and duties and furnish such services as the Board shall reasonably direct consistent with Employee's position and title with Employer; and

 (c) devote his full time, energy, and skill to the business of Employer and to the promotion of
Employer’s best interests, except for vacations, authorized leaves of absence and holidays, provided that from June 17, 2002 through August 30, 2002 (the “Transition Period”), Employee shall devote, on average, three
(3) days per week to the business of Employer. Notwithstanding anything to the contrary contained herein, nothing in the Agreement shall preclude Employee from participating in the affairs of any governmental, educational or other charitable
institution, engaging in professional speaking and writing activities, and serving as a member of the board of directors of publicly-held corporations so long as the Board, in good faith, does not determine that such activities unreasonably
interfere with the business of Employer or diminish Employee’s obligations under the Agreement. Employer will provide Employee with staffing, administrative and professional support necessary to permit Employee to achieve the responsibilities
of his position. 

 4. Compensation. Employer shall pay to Employee for all services to be performed by
Employee during the term of the Agreement: 
 (a) Salary. A “Base Salary” at the rate of
(i) $200,000 per annum, for the period from June 17, 2002 through June 30, 2003, and (ii) $290,000 per annum from July 1, 2003 to June 30, 2004, in each case payable in substantially equal periodic bi-weekly payments in
accordance with Employer’s payroll practices for other executives and managerial employees, as such practices may be determined from time to time and subject to such increases thereafter (if any) as the Board may determine in its sole
discretion based upon the performance of Employee, provided that during the Transition Period, the Base Salary shall be two-thirds of the rate otherwise payable. 
 (b) Signing Bonus. Employer has paid Employee a cash bonus of $120,000 on the date of the Original Agreement. Employee
used a portion of such bonus in order to purchase the shares of Common Stock (as defined below) referred to in subsection (d) below. 
 (c) Annual Bonus. Employee shall be eligible to receive a cash bonus of up to $30,000 for the
period from the date hereof through June 30, 2003, and a cash bonus of up to 35% of Base Salary for each twelve-month period thereafter (provided that, the Board, in its discretion, may increase such percentage from time to time); payable to
Employee no later than March 15th of the calendar
year following the calendar year in which such bonus was earned. The amount of such bonus shall be determined by the Board based upon achievement of annual performance-based milestones recommended to the Board by the Employee and approved in advance
in writing by the Board, a copy of which, in the form approved by the Board, shall be provided to the Employee (the “Annual Milestones”), provided that for the period from the date hereof through December 31, 2002, the Annual
Milestones shall be established by the Board as soon as practicable after the date hereof. 

 (d) Restricted Stock. Contemporaneously with execution of the
Original Agreement, Employer issued and sold to Employee, and Employee purchased from Employer, 800,000 shares of common stock, $.001 par value, of the Employer (“Common Stock”) at an exercise price of $.12 per share, subject to the terms
and conditions set forth in the Restricted Stock Agreement attached hereto as Exhibit A (the “Restricted Stock Agreement”). Such shares of Common Stock shall be subject to vesting as set forth in the Restricted Stock Agreement.

 (e) Performance Option Grant. Contemporaneously with the execution of the Original Agreement, Employer
granted to Employee an incentive stock option to purchase 200,000 shares of Common Stock, subject to the terms and conditions set forth in the Incentive Stock Option Agreement attached hereto as Exhibit B (the “Performance Stock
Option Agreement”). Such option shall become exercisable in four installments based upon the achievement of the Annual Milestones, as further provided in the Performance Stock Option Agreement. 
 (f) Reimbursement. Subject to the terms and conditions set forth in Section 21(e), Employee shall be entitled to
reimbursement by Employer for all reasonable expenses actually and necessarily incurred by him on its behalf in the course of his employment hereunder, for which he shall submit vouchers and such other supporting information in a form satisfactory
to Employer. 
 (g) Additional Benefits. During the term of Employee’s employment hereunder:

 i. Employee shall be entitled to four weeks of paid vacation per year, such vacation to be available for use
at the beginning of each employment year but be earned on a monthly basis. Employee also shall be entitled to all paid holidays given by Employer to its other executives and managers. 

 ii. Employee and his dependents shall be entitled to participate in and
receive benefits under any qualified or supplemental defined benefit retirement plan or defined contribution retirement plan, health and dental plan, disability plan, survivor income plan, and life insurance plan (“Benefit Plans”)
generally made available by Employer to its employees, if any, subject to and on a basis consistent with the terms, conditions, and overall administration of such Benefit Plans. 
 iii. Employer will provide Employee, in accordance with the Company’s standard policies for senior executives, a
cellular telephone, pager, laptop computer and other electronic equipment necessary for performance of Employee’s duties. 
 5. Termination. 
 (a) This Agreement shall continue as provided in Section 2 hereof until
the parties otherwise agree in writing or as hereinafter provided. This Agreement shall be terminated, either automatically or at the option of the party or parties indicated, upon the first to occur of the following events: 
 i. The death of the Employee. 
 ii. The Employee’s “Disability” for a period in excess of twelve (12) consecutive weeks or such longer period as the Employer may in its sole discretion deem appropriate. For purposes
hereof, the term “Disability” shall mean the Employee’s inability to perform the duties required of him hereunder on a substantially full-time basis. 
 iii. Written notification of termination by the Employer to the Employee, which shall specify the date of termination and
whether such termination is for “Cause”, as hereinafter defined. A “supermajority” vote of at least five (5) directors (or, if there are less than seven directors, at least 75% of the directors then serving), excluding, for
this purpose, the Employee, on the Board shall be required for the Employer to terminate this Agreement, with or without Cause, under this provision. If grounds for termination for Cause are subsequently found by the Employer to have existed prior
to termination of employment, the provisions of this subsection (iii) shall apply notwithstanding any prior voluntary termination of employment by the Employee. 

 iv. Written notification of termination by the Employee to the Employer,
which shall specify the date of termination and whether such termination is for “Good Reason”. For purposes of this Section 5(a)(iv), “Good Reason” for resignation by Employee shall include: (1) removal of Employee as a
member of the Board for any reason other than voluntary resignation or removal for Cause; (2) adverse change in Employee’s status, title, or job duties without Employee’s written consent, which materially alters or diminishes the
nature or status of Employee’s responsibilities or position; or (3) any material breach by Employer of any term or condition of this Agreement; provided, however, that a termination for Good Reason can occur only if (A) Employee gives
Employer a written notice of termination no more than 90 days after the initial existence of the conditions giving rise to Good Reason, (B) such condition has not been fully corrected within 30 days after Employer’s receipt of such notice,
and (C) Employee’s termination occurs no more than 180 days after Employer’s receipt of such notice. 
 v. The retirement of the Employee. 
 (b) For purposes of Section 5(a) hereof, grounds for
termination for “Cause” by the Employer shall be limited to (A) theft or embezzlement by the Employee of property of the Employer or any affiliate, business or professional associate or client thereof; (B) the Employee's
conviction of a felony; (C) willful violation by the Employee of any material term or condition hereof, if such violation persists after the Employee has received due notice of and sufficient opportunity to cure the same of at least thirty
(30) business days duration, unless the nature of the violation makes such procedure clearly futile, prejudicial to the

 
interests of the Employer or its affiliates, business or professional associates or clients, or otherwise unreasonable or impracticable under the circumstances; or (D) abandonment by the
Employee of his duties hereunder, which shall be deemed to have occurred if the Employee ceases to function and perform his duties hereunder, leaves the geographical area in which the Employer engages in its business or conducts himself in willful
or wanton disregard of the Employer and its best interests for any reason, including, without limitation, alcohol or drug abuse. 
 Any
termination by the Employer, pursuant to Section 5(a)(iii), that is not specifically characterized as being for Cause, shall be deemed to be without Cause. Subject to the terms set forth in Section 21 of this Agreement, in the event of
termination by the Employer without Cause and/or in the event of resignation by the Employee for Good Reason, Employer will pay Employee Severance Pay equal to twelve (12) months Base Salary, commencing upon the date of Employee’s
termination of employment, at the Employee’s then current rate pursuant to Section 4(a) hereof. Severance Pay shall be payable in equal installments in accordance with the normal payroll practices of the Employer, but shall cease
(i) upon any violation by the Employee of any provision of Exhibits A, B, and C attached hereto, or discovery by the Employer of any prior violation, or (ii) at such time as Employee commences full-time employment with another
entity if, at the time of such commencement, the cash position of the Employer is less than $6,000,000. 
 (c)
Upon termination of this Agreement because of the occurrence of any of the events set forth in Section 5(a): 
 i. Except as otherwise provided in this Agreement, the Employee shall be entitled to receive in a lump sum payment within 30 days of the date of termination (A) annual compensation pursuant to Section 4 hereof (including amounts
owed pursuant to Section 4(c) above) prorated to the date of termination hereof; and (B) any unpaid annual compensation with respect to years prior to that in which such termination occurs; but subject in all cases to the Employer’s
right of setoff with respect to any costs or expenses incurred by the Employer with respect to any act or omission by the Employee in breach or violation hereof; 

 ii. Employee shall be entitled to be paid any expenses Employee has incurred
and for which the Employee is entitled to reimbursement hereunder in a lump sum payment within 30 days of the date of termination, and will pay to the Employer, or be subject to set off therefor, any benefits which have been prepaid by the Employer
and for which the Employee will have a continuing benefit after said termination; 
 iii. Employer shall exercise
its best efforts to obtain releases from guaranties or co-signed obligations on Employer liabilities on behalf of the Employee (or Employee’s designated beneficiaries or estate) when the Employee has retired with the consent of the Employer,
died, is disabled under Section 5(a)(ii), resigns for Good Reason pursuant to Section 5(a)(iv), or is terminated without Cause by Employer pursuant to Section 5(a)(iii) hereof. If such releases are not obtained, the Employer shall and
hereby does, indemnify and hold the Employee harmless against any loss, cost or expense which the Employee might incur because of the Employee’s guaranty of, or co-signed obligation for, the Employer’s liabilities. If this Agreement is
terminated for reasons other than those set forth in the first sentence of this Section 5(c)(iii), the Employee and the Employee’s estate shall remain liable for any such guaranteed or co-signed liabilities of the Employer until the same
are paid or otherwise satisfied in full; 
 iv. Employee shall be allowed to remove from the Employer’s
business premises any personal or professional property or equipment owned by the Employee; and 

 v. Employee shall immediately return to the Employer any property of the
Employer which the Employee is holding or using. 
 (d) During the period for which Employee is entitled to
receive Severance Pay, pursuant to Section 5(b), Employer shall pay the COBRA or other premium for the continuation of coverage of Employee and his dependents under all health and dental plans or arrangements, if any, made available by Employer
in which he or his dependents were participating immediately prior to the date of his termination to the extent permissible under such plans or arrangements. If, however, Employer obtains employment with another employer or self-employment during
the period while Employee is receiving Severance Pay, such coverage shall be provided only to the extent that the coverage exceeds the coverage of any substantially similar plans in which Employee is eligible to participate. 
 (e) Nothing in the Agreement shall preclude Employer from amending or terminating any employee benefit plan or practice
provided that such amendment or termination is applicable to Employer’s executives and managers generally. 
 (f) Upon any termination of this Agreement, Employee agrees to submit his resignation as a director of Employer (and of any of its subsidiaries, if applicable). 
 6. Proprietary Information, Invention, Non-Solicitation and Non-Competition Agreement. The Employee has executed and delivered to the Employer a standard Proprietary Information, Invention,
Non-Solicitation and Non-Competition Agreement in the form attached hereto as Exhibit C. 
 7. Assignment. Neither
Employee nor Employer may assign the Agreement, except that Employer’s obligations hereunder shall be binding legal obligations of any successor to all or substantially all of Employer’s business by purchase, merger, consolidation, or
otherwise. Employer agrees to assure that in the event of a purchase, merger, consolidation, or other change in control of the business that the successor will assume this Agreement. 

 8. Employee Assignment. No interest of Employee or his spouse or any other
beneficiary under the Agreement, or any right to receive any payment or distribution hereunder, shall be subject in any manner to sale, transfer, assignment, pledge, attachment, garnishment, or other alienation or encumbrance of any kind, nor may
such interest or right to receive a payment or distribution be taken, voluntarily or involuntarily, for the satisfaction of the obligations or debts of, or other claims against, Employee or his spouse or other beneficiary, including claims for
alimony, support, separate maintenance, and claims bankruptcy proceedings. 
 9. Benefits Unfunded. All rights of
Employee and his spouse or other beneficiary under the Agreement shall at all times be entirely unfunded except with respect to pension benefit plans, if any, and no provision shall at any time be made with respect to segregating any assets of
Employer for payment of any amounts due hereunder. Neither Employee nor his spouse or other beneficiary shall have any interest in or rights against any specific assets of Employer, and the Employee and his spouse or other beneficiary shall have
only the rights of a general unsecured creditor of Employer. 
 10. Waiver. No waiver by any party at any time of any
breach by any other party of, or compliance with, any condition or provision of the Agreement to be performed by any other party shall be deemed a waiver of any other provisions or conditions at the same time or at any prior or subsequent time.

 11. Applicable Law. The Agreement shall be construed and interpreted pursuant to the laws of the Commonwealth of
Massachusetts. 
 12. Entire Agreement. The Agreement, including the Exhibits A, B, and C attached hereto,
contains the entire Agreement among Employer and Employee and supersedes any and all previous agreements, written or oral, among the parties relating to the subject matter hereof, including any prior agreement. No amendment or modification of the
terms of the Agreement shall be binding upon each of the parties hereto unless reduced to writing and signed by each of the parties hereto. 

 13. Counterparts. The Agreement may be executed in counterparts, each of which shall
be deemed an original. 
 14. Severability. In the event any provision of the Agreement is held illegal or invalid, the
remaining provisions of the Agreement shall not be affected thereby. 
 15. Successors. The Agreement shall be binding
upon and inure to the benefit of the parties hereto and their respective heirs, representatives and successors. 
 16.
Notices. Notices required under the Agreement shall be in writing and sent by registered mail, return receipt requested, to the following addresses or to such other address as the party being notified may have previously furnished to the
others by written notice: 
  

			
	If to Employer:	  	AVEO Pharmaceuticals, Inc. 75 Sidney
		  	Street, Cambridge, MA 02139
		  	Attention: Secretary
		
		  	with a copy to:
		
		  	Hale and Dorr LLP 60 State Street Boston,
		  	MA 02109 Attention: Steven D. Singer,
		  	Esq.
		
	If to Employee:	  	Tuan Ha-Ngoc
		  	Eight Kitson Park Drive
		  	Lexington, MA 02421

 17. Arbitration. Except as to any matters in respect to which Employer elects
to proceed in accordance with the provisions of Exhibit C hereto (for injunctive or similar relief), any controversy or claim arising out of the Agreement, or breach hereof, shall be settled by arbitration in the City of Boston in accordance
with the laws of the Commonwealth of Massachusetts. The Employer and Employee will in good faith mutually agree upon a single arbitrator to settle the dispute. In the event an arbitrator cannot be agreed upon, the matter shall be settled by a panel
of three arbitrators; one of whom shall be appointed by Employer, one by Employee, and the third of whom shall be appointed by the first two arbitrators. If the third arbitrator cannot be agreed upon, the third arbitrator shall be appointed by the
American Arbitration Association within 30 days after receipt of written notice of the need therefore. The

 
arbitration shall be conducted in accordance with the Employment Dispute Resolution Rules of the American Arbitration Association, except with respect to the selection of arbitrators. The
arbitrator’s determination shall be final and binding upon all parties and judgment upon the award rendered by the arbitrators may be entered in any court having jurisdiction thereof. The arbitrator shall have no authority to add to, subtract
from or modify in any way the terms or provisions of this Agreement. 
 18. Withholding. Employer may withhold from any
payment that it is required to make under this Agreement amounts sufficient to satisfy applicable withholding requirements under any federal, state or local law. 
 19. Headings. The headings contained herein are for reference purposes only and shall not in any way affect the meaning or interpretation of any provision of this Agreement. 
 20. No Presumption and Opportunity to Review. The fact that counsel for one party drafted this Agreement shall create no presumptions
and specifically shall not cause this Agreement or any part hereof to be construed against any party as the drafter. Employee hereby represents that he has had a full and fair opportunity to have this Agreement, and all related documents referred to
herein, reviewed by counsel of his own choice. 
 21. Compliance with Section 409A. Subject to the provisions in
this Section 21, Severance Pay and benefits under this Agreement shall begin only upon the date of Employee’s “separation from service” (determined as set forth below) which occurs on or after the date of termination of
employment. The following rules shall apply with respect to the distribution of Severance Pay and benefits, if any, to be provided to Employee under this Agreement. 
 (a) It is intended that each installment of Severance Pay and benefits provided under this Agreement shall be treated as a
separate “payment” for purposes of Section 409A of the Code and the guidance issued thereunder (“Section 409A”). Neither Employee nor Employer shall have the right to accelerate or defer the delivery of any such payments or
benefits except to the extent specifically permitted or required by Section 409A. 

 (b) If, as of the date of Employee’s “separation from
service” from Employer, Employee is not a “specified employee” (within the meaning of Section 409A), then each installment of Severance Pay and benefits shall be made on the dates and terms set forth in this Agreement.

 (c) If, as of the date of Employee’s “separation from service” from Employer, Employee is a
“specified employee” (within the meaning of Section 409A), then: 
 i. Each installment of
Severance Pay and benefits due under this Agreement that, in accordance with the dates and terms set forth herein, will in all circumstances, regardless of when the separation from service occurs, be paid within the short-term deferral period (as
defined in Section 409A) shall be treated as a short-term deferral within the meaning of Treasury Regulation Section 1.409A-1(b)(4) to the maximum extent permissible under Section 409A; and 
 ii. Each installment of Severance pay and benefits due under this Agreement that is not described in Section 21(c)(i)
above and that would, absent this subsection, be paid within the six-month period following Employee’s “separation from service” from Employer shall not be paid until the date that is six months and one day after such separation from
service (or, if earlier, Employee’s death), with any such installments that are required to be delayed being accumulated during the six-month period and paid in a lump sum on the date that is six months and one day following Employee’s
separation from service and any subsequent installments, if any, being paid in accordance with the dates and terms set forth herein; provided, however, that the preceding provisions of this sentence shall not apply to any installment
of severance payments and benefits if and to the maximum extent that such installment is deemed to be paid under a separation pay plan that does not provide for a deferral of compensation by reason of the application of Treasury
Regulation 1.409A-1(b)(9)(iii) (relating to separation pay upon an involuntary separation from service). Any installments that qualify for the exception under Treasury Regulation Section 1.409A-1(b)(9)(iii) must be paid no later than the
last day of the second taxable year following the taxable year in which the separation from service occurs. 

 (d) The determination of whether and when Employee’s separation from
service from Employer has occurred shall be made and in a manner consistent with, and based on the presumptions set forth in, Treasury Regulation Section 1.409A-1(h). Solely for purposes of this Section 21(d), “Employer” shall
include all persons with whom the Employer would be considered a single employer under Section 414(b) and 414(c) of the Code. 
 (e) All reimbursements and in-kind benefits provided under this Agreement shall be made or provided in accordance with the requirements of Section 409A to the extent that such reimbursements or
in-kind benefits are subject to Section 409A, including, where applicable, the requirements that (i) any reimbursement is for expenses incurred during Employee’s lifetime (or during a shorter period of time specified in this
Agreement), (ii) the amount of expenses eligible for reimbursement during a calendar year may not affect the expenses eligible for reimbursement in any other calendar year, (iii) the reimbursement of an eligible expense will be made on or
before the last day of the calendar year following the year in which the expense is incurred and (iv) the right to reimbursement is not subject to set off or liquidation or exchange for any other benefit. 
 (f) Notwithstanding anything herein to the contrary, Employer shall have no liability to Employee or to any other person if
the payments and benefits provided in this Agreement that are intended to be exempt from or compliant with Section 409A are not so exempt or compliant. 
 [Remainder of page intentionally left blank] 

 IN WITNESS WHEREOF, the undersigned have executed this Agreement as of the day and year
first above written. 
  

			
	AVEO PHARMACEUTICALS, INC.
		
	By:	 	/s/    Nicholas Galakatos
	Name: 	 	Nicholas G. Galakatos
	 Title:
	 	Chairman Compensation Committee
		
		 	/s/    Tuan Ha-Ngoc
		 	Tuan Ha-Ngoc

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