Document:

Amyris 2011 10-K Ex 10.19 First Amendment to Total Collaboration Agreement, dated November 23, 2011

CONFIDENTIAL TREATMENT REQUESTED. CERTAIN PORTIONS OF THIS DOCUMENT HAVE BEEN OMITTED PURSUANT TO A REQUEST FOR CONFIDENTIAL TREATMENT AND, WHERE APPLICABLE, HAVE BEEN MARKED WITH AN ASTERISK TO DENOTE WHERE OMISSIONS HAVE BEEN MADE. THE CONFIDENTIAL MATERIAL HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION.

FIRST AMENDMENT TO THE TECHNOLOGY
LICENSE, DEVELOPMENT, RESEARCH AND COLLABORATION AGREEMENT
ENTERED INTO AS OF NOVEMBER 23, 2011

This First Amendment (the “First Amendment”) to the Technology License, Development, Research and Collaboration Agreement entered into as of June 21, 2010 (the “Agreement”) is entered into as of November 23, 2011 (the “First Amendment Date”) by and between:

AMYRIS, Inc., a Delaware corporation, having its place of business at 5885 Hollis Street, Suite 100, Emeryville, California 94608 (“AMYRIS”),

and

TOTAL Gas & Power USA SAS, a company existing and organized under the French laws having its head office located at Tour Coupole, 2 place Jean Millier, 92810 Courbevoie, France (“TOTAL”).  

AMYRIS and TOTAL are sometimes referred to herein individually as a “Party” and collectively as the “Parties.”

RECITALS

WHEREAS, on June 21, 2010, AMYRIS and TOTAL Gas & Power USA Biotech, Inc. entered into the Agreement to define the general terms and conditions under which the Parties can establish development projects related to the research, development, production and commercialization of certain products;

WHEREAS, TOTAL Gas & Power USA Biotech, Inc., assigned the Agreement to TOTAL as set forth in that certain letter dated January 11, 2011;

WHEREAS, the Parties have entered into that certain term sheet dated as of July 26, 2011 (the “Term Sheet”), pursuant to which the Parties intend to agree upon certain agreements and amendments to the Agreement in order to conduct an exclusive strategic partnership (as described herein) for the development, production and commercialization of Renewable Diesel Products (as defined below) through the formation of a joint venture (such joint venture, whether one joint venture or multiple joint venture entities, as applicable, the “Holding JV Company”, “JV Company” or “JV Companies”) and the conduct of research and development activities to develop and industrialize processes to convert feedstock into Renewable Diesel Products;  

WHEREAS, the Parties desire to conduct the above mentioned research and development activities under the terms of the Agreement (as amended by this First Amendment), and they desire to amend the Agreement to describe and address specific provisions pertaining to such activities;

WHEREAS, this First Amendment supersedes the Term Sheet with respect to the matters set forth herein, and sets forth the terms on which the Parties will, as contemplated by the Agreement, cooperate in the development, production and commercialization of Renewable Diesel Product; and

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WHEREAS, as of the First Amendment Date, AMYRIS and TOTAL have entered into the certain binding letter describing the Parties' agreements with respect to the structure and operation of a joint venture for the development (if applicable), production and commercialization of JV Products (the “Cover Letter”).   

NOW THEREFORE, for good and valuable consideration the receipt of which is hereby acknowledged, the Parties, intending to be legally bound, agree to the following provisions and to amend the Agreement, as follows: 

		
	1.
	New Definitions.  The Parties hereby agree to add the following defined terms to Section 1:

“Additional Non-Exclusive JV Products” means any products in addition to the Initial Non-Exclusive JV Products that the Parties may, from time to time, mutually agree in writing that the JV Company will Make and Sell on a non-exclusive basis.  

“Amendment Effective Date” means August 1st, 2011.

“AMYRIS Farnesene Included IP” means any (i) AMYRIS Background IP and any AMYRIS Non-Collaboration IP, in each case that is Controlled by AMYRIS or its Affiliates as of the Amendment Effective Date and (ii) AMYRIS Non-Collaboration IP developed after the Amendment Effective Date, in each case that (x) encompass general means of practicing synthetic biology or (y) are necessary for the R&D Activities contemplated under the Renewable Diesel Product, and the activities of the JV Company.  Exhibit A lists the patents and patent applications Controlled by AMYRIS as of the First Amendment Date that are included within AMYRIS Farnesene Included IP under (y) but not (x).

“AMYRIS Hydrogenation IP” means any AMYRIS Background IP and AMYRIS Non-Collaboration IP in each case that is Controlled by AMYRIS or its Affiliates and is necessary in order to hydrogenate farnesene into farnesane. 

“Commercial Farnesene Strain” means any Commercial Strain that produces farnesene.

“Cover Letter” has the meaning defined in the recitals of this First Amendment.

“Exclusive JV Products” means (i) the Renewable Diesel Product and (ii) any Products resulting from the Biojet Development Program approved by the Management Committee on March 4, 2011. 

“Farnesene Production IP” means any and all (a) AMYRIS Farnesene Included IP and (b) Collaboration IP and (c) Improvement Scope IP, in each case that is necessary to (i) produce farnesene from fermentation of a Farnesene Strain or (ii) purify such farnesene from the fermentation medium to hydrogenation grade. 

“Farnesene Renewable Diesel Product” means a Renewable Diesel Product comprising at least farnesene or a farnesene derivative (e.g., farnesane) where the farnesene was produced using a Farnesene Strain. 

“Farnesene Strain” means any Strain that produces farnesene. 

“Initial Non-Exclusive JV Products” means those certain products designated as such on Exhibit B. 

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“Holding JV” shall mean the parent JV entity which shall initially be owned 50/50 by AMYRIS and TOTAL (or their respective Affiliates).

“JV Formation Date” means the date of formation of the Holding JV Company.

“JV Principles” means the principles for the JV Companies set forth on Annex C to the Cover Letter. 

“JV Product” means an Exclusive JV Product or a Non-Exclusive JV Product, as applicable.

“JV Project” means for the purpose of Section 11 a project undertaken by the Holding JV (or by a Party as an “Independent Project” in accordance with Section 11) to Make and Sell any Exclusive JV Product and shall include, unless otherwise agreed by the Parties, all steps in the value chain from the fermentation process of any raw material up to and including Making and Selling the applicable Exclusive JV Product.   

“Manufacture” means make and have made (including practicing and using for the foregoing purposes).

“Non-Exclusive JV Product” means an Initial Non-Exclusive JV Product or an Additional Non-Exclusive JV Product, as applicable.

“Renewable Diesel Development Project” means the renewable diesel project described in the Renewable Diesel Development Project Plan.

“Renewable Diesel Development Project Plan” means the Development Project Plan for the research, development, production, and commercialization of the Renewable Diesel Product as approved by the Parties effective as of the date of this Amendment. Such plan can be amended in writing from time to time as per the Agreement.

“Renewable Diesel Development Project Scope” means the following collective feedstock, host cell, metabolic pathway, Compound and Product:
(a) feedstock consisting of one or both: 
(i) [*] (e.g., [*]) or [*], or 
(ii) [*]:
(A) [*], 
(B) [*], 
(C) [*], 
(D) [*] and 
(E) [*];
(b) a Strain as the host cell;
(c) Mevalonate Pathway or DXP Pathway as the pathway;
(d) an isoprenoid compound as the Compound; and 
(e) Renewable Diesel Product as the Product.  

[*]

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

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“Renewable Diesel Product” means one or more fermentation-produced isoprenoid(s) that may or may not be hydrogenated or hydroprocessed, which when blended with petroleum diesel, meet the ASTM D975 specification, the EN590 European standard or the equivalent of either such standard, in each case for use as a diesel fuel. For the avoidance of doubt, Renewable Diesel Product does not include any blend with petroleum diesel. 
Capitalized terms not defined in this First Amendment shall have the meaning set forth in the Agreement.  

		
	2.
	Designation of Renewable Diesel Product as a Product and a Large Market Product.  The Parties hereby agree that (a) pursuant to Section 2.1 of the Agreement, on and after the Amendment Effective Date, the Renewable Diesel Product shall be considered a Product, notwithstanding the exclusion of Specific Products from the definition of Products, and (b) the Renewable Diesel Product is deemed a Large Market Product and the procedures set forth in Section 2.2(d) of the Agreement with regard to designating Products as Large Market Products are deemed satisfied with regard to the Renewable Diesel Product.  

		
	3.
	Renewable Diesel Development Project.  The Parties hereby agree that (a) pursuant to Section 2.2 of the Agreement, as of the First Amendment Date, the Renewable Diesel Development Project is deemed to be approved by the Management Committee  in accordance with the terms of the Agreement, (b) the Improvement Scope for the Renewable Diesel Development Project shall not be broader than the Renewable Diesel Development Project Scope, (c) any and all Inventions developed by or on behalf of either Party under the Improvement Scope IP for the Renewable Diesel Development Project, which Inventions relate to the production of farnesene from fermentation of a Farnesene Strain and purification of such farnesene from fermentation medium shall be deemed to be Main IP (and not Improvement Scope IP), and (d) notwithstanding Section 2.4 or any other provision of the Agreement, TOTAL may not exercise the TOTAL R&D Option with respect to a Farnesene Renewable Diesel Product.  

The Development Project Plan for the Renewable Diesel Development Project shall include the following parts:

(a) “[*] Subproject” which shall mean that portion of the Renewable Diesel Development Project Plan specified as the “[*] Subproject” therein. The R&D Activities for the [*] Subproject commenced as of Amendment Effective Date. 

(b) “[*] Subproject” which shall mean that portion of the Renewable Diesel Development Project Plan specified as the “[*] Subproject” therein. The [*] Subproject commenced as of the Amendment Effective Date. Any activities that would fall within the scope of the [*] Subproject will, notwithstanding any terms of the Agreement, including this First Amendment, be conducted independently by AMYRIS prior to the JV Formation Date and such independently conducted activities shall be considered outside of the R&D Activities and shall be at AMYRIS' expense and any Invention generated in the performance of such activities during such period shall be AMYRIS Non-Collaboration IP.

(c) “[*] Subproject” which shall mean that portion of the Renewable Diesel Development Project Plan specified as the “[*] Subproject” therein.  The [*] Subproject shall commence with a Feasibility Study as of the First Amendment Date. 

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

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	4.
	Governance. The governance of the Renewable Diesel Development Project shall be as follows: 

		
	(a)
	Before the formation of the Holding JV Company:  (i) the [*] Subproject and [*] Subproject will be governed as per the Agreement and (ii) the [*] Subproject will be governed by AMYRIS, provided that, in case of (ii), the Management Committee and the Joint Steering Committee as defined in the Agreement are kept informed of the progress of these subprojects and provided further that such subprojects are conducted in accordance with the Renewable Diesel Development Project Plan.  All other aspects of the Renewable Diesel Development Project shall be governed in accordance with the governance provisions set forth in the Agreement. 

		
	(b)
	After the formation of the Holding JV Company: All aspects of the Renewable Diesel Development Project shall be governed in accordance with the governance provisions set forth in the Agreement.

		
	5.
	Use of Collaboration IP.  In case (i) the Renewable Diesel Development Project is terminated and (ii) the Holding JV Company is not formed, the Parties hereby agree that the restrictions set forth in Section 2.2(d) of the Agreement regarding use of Collaboration IP in a project competing with the Renewable Diesel Development Project having farnesene as the Lead Compound and Farnesene Renewable Diesel Product as the Product shall not apply to AMYRIS with respect to any Collaboration IP developed under the Renewable Diesel Development Project.

		
	6.
	Funding.  Notwithstanding Sections 2.7(a)  and (c) of the Agreement, the Parties hereby agree to fund the Renewable Diesel Development Project as follows: 

(a) TOTAL shall solely fund the first thirty million USD ($30,000,000) of R&D Costs for R&D Activities constituting the [*] Subproject and the [*] Subproject, collectively, which amounts shall be separate and in addition to the amount of fifty million USD ($50,000,000) to be funded by TOTAL pursuant to Section 2.7(c) of the Agreement.

(b) For any such R&D Costs incurred following the JV Formation Date for R&D Activities constituting the [*] Subproject and the [*] Subproject, collectively, not funded by TOTAL pursuant to the foregoing clause (a), TOTAL shall solely fund such R&D Costs in accordance with the budget in the Renewable Diesel Development Project Plan (i) up to ten million USD ($10,000,000) (the “Second Funding Amount”) in calendar year 2012 and (ii) if agreed by the Management Committee, up to an additional ten million USD ($10,000,000) in calendar year 2013 (which determination shall be made no later than [*] prior to the end of calendar year 2012).  All funding provided by TOTAL under this clause (b) will be deemed to be part of the $50 million to which TOTAL is committed to fund under Section 2.7(c) of the Agreement. 

(c) For any such R&D Costs for R&D Activities constituting the [*] Subproject and the [*] Subproject, collectively, not funded by TOTAL pursuant to the foregoing clause (a) or (b), the Parties shall share such R&D Costs on an equal basis as set forth in Section 2.7(a) of the Agreement. For clarity, in this 

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

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particular case of this clause (c), the exception of Section 2.7(c) of the Agreement mentioned in Section 2.7(a) of the Agreement shall not apply.

(d) For the R&D Costs of R&D Activities constituting the [*] Subproject and performed after the JV Formation Date, the Parties shall share such R&D Costs on an equal basis as set forth in Section 2.7(a) of the Agreement. For clarity, in this particular case of this clause (d), the exception of Section 2.7(c) of the Agreement mentioned in Section 2.7(a) of the Agreement shall not apply.

(e) If an improvement to a Commercial Farnesene Strain, other than by means of [*] is desired by the JV Company, then the JV Company shall fund such work to be performed by AMYRIS on behalf of the JV Company, provided that such improved Commercial Farnesene Strain is not already licensed to the JV Company under the license agreement to be executed by AMYRIS and the JV Company in connection with the Definitive JV Agreements.  

(f)  AMYRIS shall provide to TOTAL two invoices as of the First Amendment Date, as follows:  

(i) one invoice for the past actual and documented R&D Costs for the Renewable Diesel Project incurred for the period beginning [*] and ending [*] and for which TOTAL is responsible under Section 6 “Funding” of this First Amendment, plus 

(ii) one invoice for expected R&D Costs in accordance with the budget in the Renewable Diesel Development Project Plan for the Renewable Diesel Project during the Calendar Quarter [*], and for which TOTAL is responsible under  paragraph (a) and, if applicable, paragraph (c) of  Section 6 “Funding” of this First Amendment.  

TOTAL shall pay AMYRIS the invoiced amounts within [*] following receipt of such invoices.

AMYRIS shall provide TOTAL with an updated invoice reflecting the actual and documented amounts of the estimated R&D Costs specified in clause (f) (ii) within [*] after the end of the Calendar Quarter  [*].

		
	7.
	Exclusivity.   Notwithstanding the provisions of Section 2.8(a) of the Agreement, the one-year period described in the first sentence of Section 2.8(a) shall not apply [*]. 

		
	8.
	Non-Formation of the Holding JV Company. The Parties agree that if the Definitive JV Agreements (as defined in the Cover Letter) have not been executed by March 31, 2012 or such later date as is mutually agreed in writing by the Parties (the “Holding JV Formation Deadline”), then:

		
	(a)
	the Renewable Diesel Development Project shall terminate;

		
	(b)
	The funding by TOTAL of the remaining R&D Activities in the Renewable Diesel Development Project shall immediately stop (other than for noncancellable amounts 

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

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previously incurred by AMYRIS in accordance with the budget for the Renewable Diesel Development Project for activities conducted on or before such date); and

(c)  the Renewable Diesel Product shall cease to be a “Product” for the purposes of Article 3 of the Agreement. 

		
	9.
	AMYRIS Included IP.

A.  AMYRIS Farnesene Included IP and AMYRIS Hydrogenation IP as listed in Exhibit A shall be considered included in the AMYRIS Included IP pursuant to Section 6.1(c) of the Agreement (without the need for the procedures set forth therein) solely for the Renewable Diesel Development Project for all purposes under the Agreement, except as otherwise provided in this First Amendment.  Any other Background IP or Non-Collaboration IP that is Controlled by AMYRIS or its Affiliates may be introduced as AMYRIS Included IP as per the Agreement.

B.  Notwithstanding the scope of the licenses otherwise granted or to be granted to the JV Company under the Agreement, including Section 6.6(a) of the Agreement, the license to be granted by AMYRIS to the JV Company for Farnesene Renewable Diesel Product under its interest in the Farnesene Production IP and AMYRIS Hydrogenation IP shall be limited to: (i) [*] license to Make and Sell Farnesene Renewable Diesel Product manufactured using the Commercial Farnesene Strain for the Farnesene Renewable Diesel Product (but not farnesene itself, with respect to which the JV Company shall be granted only the Biofene License as mentioned in Section 9B(ii)), and (ii) [*] license to Manufacture farnesene (such [*] license, the “Biofene License”) using the Commercial Farnesene Strain for the Farnesene Renewable Diesel Product solely for (A) the purpose of Manufacturing the Farnesene Renewable Diesel Product from such farnesene and (B) such other purposes as are mutually agreed by AMYRIS and TOTAL in writing, in each case (i) and (ii), in accordance with such license and the terms governing such JV Company.  The terms of the Biofene License under Farnesene Production IP shall be subject to conditions [*].  These conditions shall include, but may not be limited to the following:  (1) the JV Company will be permitted to engage in [*] with respect to the Commercial Strain for the Renewable Diesel Product, (2) the JV Company will be permitted to transfer the Commercial Farnesene Strain to any contract manufacturer in accordance with the license terms between AMYRIS and the JV Company, (3) the license agreement granting the Biofene License shall include other reasonable provisions, including without limitation, reporting, audit, and inspection rights in order to protect the Farnesene Production IP and the Commercial Farnesene Strain, and (4) the JV Company shall not and shall not allow any other Person to reverse engineer any Commercial Farnesene Strain, engineer any other strain from the Commercial Farnesene Strain, use the Commercial Farnesene Strain, or distribute, disclose, or transfer the Commercial Farnesene Strain or any related AMYRIS Farnesene Included IP to any Third Party (other than a contract manufacturer as described above) in each case for any purpose other than the licensed purpose. Notwithstanding Section 9B, the financial terms of any licenses granted by AMYRIS to the JV Company shall be consistent with the content of the Cover Letter and the JV Principles.

C.  AMYRIS has informed TOTAL that AMYRIS has received the following two grants from the U.S. government:  (i) Scale-Up and Mobilization of Renewable Diesel & Chemical Production from Common Intermediate Using US-Based Fermentable Sugar 

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

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Feedstocks (IBR Cooperative Agreement), Award No. DE-EE0002869 (the “IBR Grant”) and (ii) Biocatalyst Development for the National Advanced Biofuels Consortium (NABC) Subcontract ZFT-0-40623-01 (the “NABC Grant”). AMYRIS has further informed TOTAL that none of the subject matter disclosed by the patents and patent applications listed in Exhibit A was funded by either the IBR Grant or the NABC Grant, and TOTAL is relying on such representation in entering into this First Amendment. 

TOTAL acknowledges that it is possible that after the Amendment Effective Date, AMYRIS may file one or more patent applications [*], which patent applications disclose inventions generated under either the IBR Grant or the NABC Grant, thereby subjecting such patent applications and any resulting patents and their use to certain restrictions and obligations to the United States government.  TOTAL acknowledges that the rights of AMYRIS, TOTAL and their respective Affiliates', and the rights of the JV Company with regard to the applicable patent applications and patents will be subject to any rights of the U.S. government or any other relevant government entity arising as a result of such grants (including march-in rights) and will be subject to any restrictions on such exploitation.  In such case, the Management Committee shall agree on how to mitigate or eliminate any adverse impact on the Parties and/or the JV Company.

Before entering into any grant or contract that may provide any government or non-for profit entity any rights (e.g., rights provided to the U.S. Government under 35 U.S. 200 et seq. or any similar provisions of foreign law) to any patent application or patents resulting from work done in connection with such grant or contract that might be useful in connection with the conduct of the Renewable Diesel Development Project or to Manufacture farnesene to make Renewable Diesel Products or to Make and Sell Renewable Diesel Products, AMYRIS shall notify the Management Committee, which shall agree on how to mitigate or eliminate any adverse impact on the Parties and/or the JV Company. 

		
	10.
	Limitation of Rights to Use Farnesene Production IP from Licenses.  The Parties hereby agree that, notwithstanding the terms of the Agreement, the licenses granted or to be granted  to TOTAL in Sections:

		
	(i)
	6.2(c), 6.3(a), 6.3(d) and 6.3(e) of the Agreement with respect to Renewable Diesel Products will not include the right for TOTAL to use Farnesene Production IP for the production of farnesene from fermentation of a Farnesene Strain and subsequent purification of farnesene to hydrogenation grade, except in each case to the extent necessary for TOTAL to exercise the Exclusive Products Sole Risk Production Right of First Refusal described in Section 11 below for Renewable Diesel Product, and 

		
	(ii)
	6.3(b) will exclude the right for TOTAL to use Farnesene Production IP for further optimization of a Commercial Farnesene Strain other than by means of [*]. 

The foregoing limitations in this Section 10 shall not limit or deprive TOTAL of any rights granted to TOTAL prior to execution of this First Amendment, or that may be granted to TOTAL under the Agreement with respect to (a) any Collaboration IP not made in connection with the Renewable Diesel Development Plan, or (b) with respect to any Product other than a Renewable Diesel Product.

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

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The Parties also hereby agree that, notwithstanding the terms of Section 10.6 of the Agreement, the license grants set forth in or extended under Section 10.6.1(a) of the Agreement exclude the right for TOTAL to use Farnesene Production IP for the production of farnesene from fermentation of a Farnesene Strain and subsequent purification of farnesene to hydrogenation grade.
 
		
	11.
	Exclusive Products Sole Risk Production Right of First Refusal.  The Parties agree that the “Production Right of First Refusal” set forth in Section 3.2(d)(i) of the Agreement shall be replaced by the following for the purpose of Exclusive JV Products:

A. The Parties agree that any JV Project may be conducted by one or both Party(ies) or its Affiliate(s) independently from one another and from the Holding JV Company, provided that the applicable Party or its Affiliate (the “Proposing Party”) shall offer to the other Party (the “Receiving Party”) an Exclusive Products Sole Risk Production Right of First Refusal” as described in this Section 11 to participate in the applicable JV Project on an [*] basis through the Holding JV Company unless otherwise agreed by the Parties (the “Proposed Project”). 
If the Receiving Party exercises this Exclusive Products Sole Risk Production Right of First Refusal with respect to a particular JV Project, then the Holding JV Company will be the vehicle for the investment of both Parties in the Proposed Project unless otherwise agreed by the Parties. The Proposing Party shall not commence a JV Project for the Exclusive JV Product except in compliance with this Section 11.
B.  In the event that a Proposing Party desires to independently launch a JV Project for an Exclusive JV Product (either alone or with one or more Third Parties), it shall first provide the Receiving Party written notice containing a description of the Proposed Project and a description of the terms available to participate in the Proposed Project. 
C.  If within [*] of receipt of the notice described in Section 11(B) above, the Receiving Party provides notice to the Proposing Party that the Receiving Party or any of its Affiliates desires to enter into such a transaction with the Proposing Party on such terms and conditions, then the Proposing Party shall not commence the Proposed Project without the Receiving Party and/or its Affiliate and the Holding JV Company (or other applicable JV Company) entering into an agreement for the Proposed Project with the Proposing Party (which agreement may include one or more Third Parties).  
D.  Upon the earlier of (1) the Receiving Party providing the Proposing Party with written notice that the Receiving Party does not wish to enter into such Proposed Project through the Holding JV Company and (2) the expiration of the [*] period following the date the notice described in Section 11(B) above was provided to the Receiving Party (provided that the Receiving Party has not provided the Proposing Party with written notice that it desires to enter into such a transaction as described in Section 11(C) during such [*] period), then, subject to subsection (G) below, the Proposing Party shall thereafter be free to engage in the Proposed Project either alone or with one or more Third Parties outside the JV Company (such project, an “Independent Project”).

E.  Before entering into any agreement with a Third Party with respect to any activities substantially similar to a Proposed Project on terms more favorable to the Third Party than the terms last offered to and declined by the Receiving Party with respect to the Proposed Project, the Proposing Party shall offer to the Receiving Party the opportunity to participate in such activities on the terms it intends to offer to such Third Party and the [*] 

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

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offer period (and the corresponding commitment not to commence such activities while the Receiving Party is evaluating its interest in such Proposed Project) shall commence anew.  
F.  If the Proposing Party elects to engage in an Independent Project, the Receiving Party and/or the Holding JV Company, as needed, shall grant to the Proposing Party on a non-exclusive basis all the licenses necessary to engage in the Independent Project under the intellectual property Controlled by the Receiving Party and/or the Holding JV Company (for clarity such licenses shall include the right to Manufacture, use and import intermediates of the Exclusive JV Product [*] for the purpose of incorporating such intermediates into the  Renewable Diesel JV Product and any license required to be granted by the Receiving Party shall not be required to be broader in scope than the rights granted to the Holding JV Company with respect to the applicable Exclusive JV Product and the foregoing licenses may be subject to terms and conditions analogous to those set forth in the license from the Receiving Party to the Holding JV Company). The Proposing Party shall pay the Receiving Party a royalty equal to [*] % of Net Income deriving from the Independent Project. For the purpose of calculating such royalty, Net Income with respect to a unit of any Exclusive JV Products produced under the Independent Project and used by the Proposing Party or its Affiliates internally shall be equal to (A) the then-current market price per unit of such Exclusive JV Products (or, if not available, an appropriate proxy as mutually agreed by the Parties) less (B) the per-unit cost of production associated with such Exclusive JV Products and less (C) per unit selling expenses that the Proposing Party would have incurred had such Exclusive JV Products been sold to a Third Party and less (D) any other deductions that would be typically taken under a Net Income calculation (as described in the example set forth in Exhibit D of the Agreement) if there were a sale to a Third Party. 
G.  In the event that the Receiving Party declines or otherwise does not exercise the Exclusive Products Sole Risk Production Right of First Refusal within the relevant time period as described above (whether in the first instance or pursuant to clause (E) above), then the Receiving Party may at any time (until expiration of the right as described below) elect to exercise an opportunity to opt in to the Proposed Project on the terms last offered (an “Exclusive Sole-Risk Opt-In Right”).  The Exclusive Sole-Risk Opt-In Right, if exercised, would be effected by transitioning the Proposed Project to the Holding JV Company (or such other JV Company agreed by the Parties) as promptly as practical and in connection therewith the Proposing Party receiving an amount equal to [*] (“Repayment Base Amount”) (where the payment therefore shall be made by the Holding JV Company or as otherwise agreed by the Parties) as follows:

		
	•
	The Repayment Base Amount plus interest in USD thereon at [*] of the Repayment Base Amount, if the Exclusive Sole-Risk Opt-In Right is exercised prior to [*] of the notice of the Proposed Project to the Receiving Party.  

		
	•
	The Repayment Base Amount plus interest in USD thereon at [*] of the Repayment Base Amount, if the Exclusive Sole-Risk Opt-In Right is exercised after [*] of the notice of the Proposed Project to the Receiving Party but prior to [*] thereof.

		
	•
	The Repayment Base Amount plus interest in USD thereon at [*] of the Repayment Base Amount, if the Exclusive Sole-Risk Opt-In Right is exercised after [*] of the notice of the Proposed Project to the Receiving Party but prior to [*] thereof.  

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

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Each Exclusive Sole-Risk Opt-In Right shall lapse as of [*] of the notice of the Proposed Project to the Receiving Party. If a Receiving Party timely exercises its Sole Risk Opt-In Right, and commits to fund its portion of the Repayment Base Amount for a particular Proposed Project such Proposed Project shall be developed exclusively through the Holding JV.
H.  The Exclusive Sole Risk Production Right of First Refusal mechanism described in this Section 11 (i) will not apply to either Party before the completion of the Renewable Diesel Development Project and (ii) will apply only if TOTAL has chosen not to exercise the TOTAL Royalty Option (as defined in Section 12 below).
I.  Any Inventions conceived or reduced to practice in the performance of the Independent Project shall be treated under the Agreement (as amended in this First Amendment) as Collaboration IP.

		
	12.
	TOTAL Option Upon the Renewable Diesel Project Completion Date

As used herein, “Renewable Diesel Project Completion Date” shall be [*] or any other date as determined by the Management Committee to achieve the End-Project Milestone (as defined in the Renewable Diesel Development Project Plan). 
A.    For a period of [*] following the Renewable Diesel Project Completion Date, TOTAL shall have the option, exercisable in its sole discretion, to notify AMYRIS in writing that TOTAL does not wish to pursue the production or commercialization of the Renewable Diesel Product (such option, the “TOTAL Royalty Option”).  Provided TOTAL timely notifies AMYRIS of its decision to exercise the TOTAL Royalty Option (such date of notification, the “Royalty Notification Date”), then the following provisions shall apply:
B.    Effective as of the Royalty Notification Date, all of TOTAL's rights in or to any and all Collaboration IP developed during the performance of the Renewable Diesel Development Project Plan (hereinafter, the “Diesel Collaboration IP”) shall terminate and TOTAL shall assign to AMYRIS all right, title and interest of TOTAL in and to Diesel Collaboration IP.  TOTAL shall, at AMYRIS' reasonable expense, execute all documents and take all actions reasonably requested by AMYRIS from time to time to perfect AMYRIS' title to and ownership thereof.  Prior to the Royalty Notification Date, TOTAL shall not assign or transfer to any of its Affiliates or third parties any such right, title and interest so as to ensure that AMYRIS obtains the benefit of this provision.
C.    In consideration of the benefits AMYRIS may derive from the technology and intellectual property developed during the Renewable Diesel Development Project and TOTAL's assignment of its right, title and interest in and to the Diesel Collaboration IP, commencing on the Royalty Notification Date and ending on the date when AMYRIS has paid TOTAL an aggregate amount equal to $[*] (the “Aggregate Royalty Amount”), AMYRIS shall pay TOTAL a royalty of [*] percent ([*]%) of Net Income (as defined in the Collaboration Agreement) on a yearly basis derived from (i) any licenses under or sales of the Diesel Collaboration IP by AMYRIS or any of its Affiliates to third parties, but not to the extent such licenses or sale relate to the use of the Diesel Collaboration IP for the Initial Non-Exclusive JV Products, and (ii) the Net Income (as defined in the Agreement) of AMYRIS on a consolidated basis other than that derived from a Product resulting from the Biojet Development Program and the Non-Exclusive JV Products (the “TOTAL Diesel IP Royalty”).  In addition, in the event AMYRIS sells all or 

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

11

substantially all of its renewable diesel business prior to the time the time the Aggregate Royalty Amount has been paid, AMYRIS shall pay TOTAL [*] percent ([*]%) of the net proceeds from such sale up to the then-remaining unpaid amount of the Aggregate Royalty Amount.
For clarity, Net Income shall be calculated in accordance with generally accepted accounting principles consistently applied by AMYRIS and in the event that the foregoing Net Income is negative for a given fiscal quarter, AMYRIS shall not be required to pay any royalty for such fiscal quarter).
D.     AMYRIS shall provide TOTAL, upon reasonable advance notice, all information, and access to all advisors and representatives of AMYRIS, as reasonably requested by TOTAL in order for a third party auditor appointed by TOTAL and reasonably acceptable to AMYRIS, and subject to mutually agreeable customary confidentiality restrictions, to verify all calculations and amounts paid pursuant to this Section 12 and to report any inaccuracies to TOTAL.
E.    Notwithstanding anything in this Section 12, any JV Company established with regard to JV Products other than Renewable Diesel Products will continue to operate following any exercise of the TOTAL Royalty Option.
F.    The TOTAL IP Royalty payments shall cease from the date when the sum of all such TOTAL Royalty payments equals $[*]. 
G.    Notwithstanding anything in this Section 12, beginning on the [*] from the Royalty Notification Date, the aforementioned royalty in section C (ii) shall be additionally derived from the Non-Exclusive JV Products.

		
	13.
	Freedom to Operate. 

A. Freedom to Operate Analyses.  AMYRIS and TOTAL undertake to perform a freedom to operate (“FTO”) analysis in relevant jurisdictions with respect to intellectual property owned or controlled by Third Parties (“Third Party IP”) relevant to the proposed development, production and commercialization of the Farnesene Renewable Diesel Products (“Renewable Diesel Analysis”) prior to the execution of the Definitive JV Agreements  and no later than [*], with the objective to determine whether, and to what extent, third party intellectual property rights may limit or preclude (i) the use of the AMYRIS intellectual property to Make and Sell Renewable Diesel Product or (ii) the performance of the Renewable Diesel Project Plan. In addition, prior to starting the development, production or commercialization of any other JV Product in the JV, the Parties shall conduct a similar freedom to operate analysis with regard to Third Party IP relevant to the development, production or commercialization of any JV Products of mutual interest to the Parties from such project on a mutually acceptable timetable.  Except as otherwise agreed, the costs of the Renewable Diesel Analysis shall be included in R&D Costs for the [*] Subproject and the costs of any other FTO shall be as mutually agreed.

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

12

B. Common Interest Agreement. Prior to commencing the Renewable Diesel Analysis described above,  the Parties shall enter into a common interest agreement (the “Common Interest Agreement”) covering the exchange of information among the Parties and their counsel for the purposes of conducting such an FTO analysis in accordance with Paragraph A.

C.  Result of FTO Analysis.  
		
	(i)
	Within [*] of the completion of the Renewable Diesel Analysis in accordance with the agreed search and evaluation plan detailing specific deliverables and assessments of identified patent applications and patents owned by Third Parties, each Party shall notify the other if it considers that there is a Significant Risk.  For the purpose of this section, “Significant Risk” means any risk that Third Party IP may preclude and/or Significantly Delay the development of Renewable Diesel Products in accordance with the Renewable Diesel Development Project Plan or the commercialization of Renewable Diesel Products. If not such notification is provided, then the consequences described in clause (iii)(a) below shall apply.

For the purpose of this Section 13, “Significantly Delay” means an expected delay of [*] or more.

		
	(ii)
	Upon receipt of such a notice, the Parties shall discuss their concerns about the Significant Risk, including whether to suspend or terminate any or all of the R&D Activities for the Renewable Diesel Project.  If the Parties disagree after discussing for a period of [*] upon receipt of such notice, then each Party shall have the right, at its election to:

		
	(A)
	 terminate the Renewable Diesel Development Project, if it believes in good faith that the Significant Risk will have a material adverse impact on the Renewable Diesel Project (i.e., if the Third Party IP appears necessary (i.e., design around would Significantly Delay or significantly increase the cost) for the development, production and/or commercialization of Renewable Diesel Products). Any notice of an intent to terminate on such basis must be provided no later than [*] prior to the Holding JV Formation Deadline as agreed by the Parties; or

		
	(B)
	suspend some or all of the R&D Activities (including the corresponding funding) because it believes in good faith that a Significant Risk may (i) prevent the use of the applicable IP for, or (ii) Significantly Delay the development, production and/or the commercialization of Renewable Diesel Products; any notice of suspension must be provided no later than [*] before the Holding JV Formation Deadline as agreed by the Parties. The suspension period shall last until there is a decision by the Management Committee of any appropriate corrective actions. 

		
	(iii)
	At the completion of the process described above, the following shall apply: (a) if there is not a termination of the R&D Activities for the Renewable Diesel Project, TOTAL may not decline to enter into the Definitive JV Agreements on the basis of the results of the Renewable Diesel Product Analysis or (b) if there is a termination of the R&D Activities for the 

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

13

Renewable Diesel Project, neither Party shall be obligated to enter into any JV Company, except, at TOTAL's request, the Parties shall enter into a JV Company to Make and Sell N.1 and/or N.3 JV Products.

		
	(iv)
	Any Dispute regarding whether there is basis for termination as set forth in (A) or suspension as set forth in (B) shall be resolved in accordance with Section 12.2 of the Agreement.  

D. Representation and Warranty. 

AMYRIS represents and warrants as of the First Amendment Date that to its knowledge there are no pending or issued patent rights of any Third Party that foreclose practice of any AMYRIS Technology for the following purposes: (i) to make farnesene using the Mevalonate Pathway, or (ii) to make or commercialize Farnesene Renewable Diesel Products.

		
	14.
	Exception to AMYRIS Representations, Warranties and Covenants in Section 8.2(q).  The Parties hereby agree that by exception to Section 8.2(q) of the Agreement, Farnesene Strains may be disclosed to any Third Party during the Term by AMYRIS, provided that such disclosure is (a) under conditions of confidentiality and restrictive use to protect their proprietary nature and commercial value and (b) solely in furtherance of AMYRIS' business for products other than Exclusive JV Products.

		
	15.
	Construction.  The principles set forth in Section 13.12 of the Agreement shall apply to this First Amendment.  References to Sections are references to sections of the Agreement except as otherwise expressly provided.

		
	16.
	Amendment Effective Date; Incorporation of Terms; Continuing Effect.  This First Amendment shall be deemed effective for all purposes as of the Amendment Effective Date.  The amendment to the Agreement set forth in this First Amendment shall be deemed to be incorporated in, and made a part of, the Agreement, and the Agreement and this First Amendment shall be read, taken and construed as one and the same agreement.  Except as otherwise expressly amended by this First Amendment, the Agreement shall remain in full force and effect in accordance with its terms and conditions.  

		
	17.
	Entire Agreement.  This First Amendment contains the entire agreement between TOTAL and AMYRIS with respect to the subject matter hereof and supersedes any and all prior agreements and understandings, oral and written, with respect to such matters, including the Term Sheet, effective as of July 26, 2011, between AMYRIS and TOTAL Gas & Power USA SAS. In the event of any inconsistency between this First Amendment and the Cover Letter or JV Principles, this First Amendment shall control.

14

THIS FIRST AMENDMENT IS EXECUTED BY THE AUTHORIZED REPRESENTATIVES OF THE PARTIES AS OF THE DATE FIRST WRITTEN ABOVE.

	
									
	AMYRIS, Inc.
	 
	TOTAL Gas & Power USA SAS

	By:
	/s/ John G. Melo
	 
	By:
	/s/ A. Chaperon

	Name:  John G. Melo
	 
	Name:  A. Chaperon

	Title:  President and CEO
	 
	Title:  President

15

Exhibit A
AMYRIS Controlled Patents and Patent Applications within AMYRIS Farnesene Included 
IP and AMYRIS Hydrogenation IP

EXIBIT A

I.Amyris Patents and Patent Applications

	
				
	Amyris Ref. No.
	Serial No & Filing Date
	Title
	Status

	[*]
	US 11/754,235
Filed 05/25/2007
	Production or Isoprenoids
	Issued as US 7,659,097 on 02/09/2010

Published as US 20080274523 on 11/06/2008

	[*]
	[*]
	[*]
	 

	[*]
	PCT/US2007/069807 
Filed 05/25/2007
	Production of Isoprenoids
	Published as WO 2007/140339 on
12/06/2007

Entered National Phase in Australia, Brazil, Canada, China, Columbia, El Salvador, Europe, Guatemala, Honduras, India, Indonesia, Japan, South Korea, Malaysia, Mexico, Mozambique, Nigeria, Singapore, South Africa, Trinidad & Tobago, Vietnam

	[*]
	[*]
	[*]
	 

	[*]
	PCT/US2007/012467 Filed:05/25/2007
	Apparatus for Making a Bio-Organic Compound
	Published as WO 2007/139924 on 12/06/2007

Entered National Phase in Australia, Brazil, Canada, China, Columbia, El Salvador, Europe, Guatemala, Honduras, India, Indonesia, Japan, South Korea, Malaysia, Mexico, Mozambique, Nigeria, Singapore, South Africa (issued as 2008/09957 on 08/10/2010), Trinidad & Tobago, Vietnam

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

	
				
	Amyris Ref. No.
	Serial No & Filing Date
	Title
	Status

	[*]
	US 11/869,673 
Filed 10/09/2007 
	Fuel Compositions Comprising Farnesane and Farnesane Derivatives and Method of Making and Using the Same
	Issued as U.S. Patent No. 7,399,323 on 07/15/2008 

Published as US 20080098645 on 05/01/2008 

	[*]
	US 11/973,901 
Filed 10/09/2007 
	Fuel Compositions Comprising Farnesane and Farnesane Derivatives and Method of Making and Using the Same
	Issued as U.S. Patent No. 7,846,222 on 12/07/2010 

Published as US 20080083158 on 04/10/2008 

	[*]
	PCT/US2007/021890 Filed 10/10/2007
	Fuel Compositions Comprising Farnesane and Farnesane Derivatives and Method of Making and Using the Same
	Published as WO 2008/045555 on 04/17/2008

Entered National Phase in Australia, Brazil, Canada, China, Columbia, El Salvador, Europe, Guatemala, Honduras, Hong Kong, India, Indonesia, Japan, South Korea, Malaysia, Mexico, Mozambique, Nigeria, Singapore, South Africa (issued as 2009/02205 on 09/29/2010), Trinidad & Tobago, Vietnam

	[*]
	US 12/595,600 
Filed 04/14/2008 
	DXP Production of Isoprenoids
	Filed in US from PCT. 
Published as WO 2008/128159 on 10/23/2008 

Published as US 20100178679 on 07/15/2010 DXP pathway

	[*]
	US 12/234,589 
Filed 09/19/2008 
	Production of Isoprenoids
	Published as US 20090137014 on 05/28/2009

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

	
				
	Amyris Ref. No.
	Serial No & Filing Date
	Title
	Status

	[*]
	US2008/010886 
Filed 09/19/2008 
	Production of Isoprenoids
	Published as WO 2009/042070 on 04/02/2009 

Entered National Phase in Australia, Brazil, Canada, China, Europe, Japan, India, Mexico, and South Africa

	[*]
	US 12/753,413
Filed 04/02/2010
	Stabilization & Hydrogenation Methods for Microbial-Derived Olefins
	Published as US 20100267971 on 10/21/2010

	[*]
	PCT/US2010/029774 Filed 04/02/2010
	Stabilization & Hydrogenation Methods for Microbial-Derived Olefins
	Published as WO 2010/115097 on 10/07/2010

	[*]
	[*]
	[*]
	 

	[*]
	[*]
	[*]
	 

	[*]
	[*]
	[*]
	 

	[*]
	[*]
	[*]
	 

	[*]
	[*]
	[*]
	 

	[*]
	[*]
	[*]
	 

	[*]
	[*]
	[*]
	 

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

II.Patents and Patent Applications Licensed from University of California

	
				
	Amyris Ref. No.
	Serial No & Filing Date
	Title
	Status

	[*]
	PCT/US05/026190 Filed: 07/21/05
	Genetically Modified Host Cells and Use of Same for Producing Isoprenoid Compounds
	Published as WO 2006/014837 on 02/09/06

Entered National Phase in Australia, Brazil, Canada, China, Europe, Japan, Mexico, United States, Vietnam, & South Africa (issued as 2007/00753 on 5/28/2008)

	[*]
	PCT/US2007/020790 Filed 09/25/07
	Production of Isoprenoids and Precursors Thereof
	Published as WO 2008/039499 on 04/03/2008

Entered National Phase in Brazil, Europe, India, & United States

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

III.[*]

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

Exhibit B
Initial Non-Exclusive JV Products

	
				
	 
	JV Product
	For use in the following Fields
	Territory

	N.1
	[*]
	[*]
	World wide

	N.2
	[*]
	[*]
	World wide

	N.3
	[*]
	[*]
	World wide

	N.4
	[*]
	[*]
	World wide

	N.5
	[*]
	[*]
	World wide

	N.6
	[*]
	[*]
	World wide

	N.71
	[*]
	[*]
	World wide

1.    N.7 included as an Initial Non-Exclusive JV Product subject to Section 2(C)(ix) of the JV Principles.

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.Amyris 2011 10-K Ex 10.32 Lease Agreement dated August 10, 2011 between Techno Plaza and AB

CONFIDENTIAL TREATMENT REQUESTED. CERTAIN PORTIONS OF THIS DOCUMENT HAVE BEEN OMITTED PURSUANT TO A REQUEST FOR CONFIDENTIAL TREATMENT AND, WHERE APPLICABLE, HAVE BEEN MARKED WITH AN ASTERISK TO DENOTE WHERE OMISSIONS HAVE BEEN MADE. THE CONFIDENTIAL MATERIAL HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION.

Lease Agreement for the ground floor and first floor side B Building 3 Techno Plaza

LEASE AGREEMENT

		
	1.
	PARTIES

		
	1.1.
	LESSOR:

TECHNO PARK EMPREENDIMENTOS E ADMINISTRAÇÃO IMOBILIÁRIA LTDA., with head office in the City of Campinas, at Av. Dr. Moraes Salles, No. 711, 1st Floor, Corporate Taxpayer Identification Number CNPJ/MF No. [*], the articles of organization of which were duly registered with the Registry of Commerce of the State of São Paulo (JUCESP) under No. 35.222.833.504 on November 11, 2008, hereby represented by its manager, Mr. Miguel Gilberto Pascoal, Brazilian, married, architect, bearer of Identity Card No. [*], Individual Taxpayer Identification Number CPF No. [*], resident in the city of Campinas, State of São Paulo. 

		
	1.2
	LESSEE:

AMYRIS BRASIL LTDA., with head office in the City of Campinas, at Rua James Clerk Maxwell, 315, Condomínio Empresarial Techno Park, Corporate Taxpayer Identification Number CNPJ/MF No. 09.379.224/0001-20, herein represented in accordance with its Articles of Organization.

		
	2.
	SUBJECT MATTER

		
	2.1
	LESSOR declares to be the owner and lawful holder of twelve (12) office spaces,  No. 11 B to 16B and 21B to 26B, which jointly, inseparably and irreversibly constitute the Real Property,  totaling a 1,529.98 m2  private area, the first six of which are located on the Ground Floor and the other six on the first floor, all in Block “B” of Building “3”, which is part of a commercial development located at Av. John Dalton, No. 301, Lot 2, Block “C”, of the Private Real Estate Development Techno Park Campinas, in the city of Campinas, State of São Paulo, in accordance with the plan approved by the Local Government of the City of Campinas on October 10, 2007, filed under No. 07/11/8807. These office spaces entitle lessee to the use of forty-eight (48) medium-sized dedicated uncovered parking spaces for passenger vehicles, of which thirty-six (36) parking spaces are exclusively reserved for the users of these office spaces and twelve (12) parking spaces are included in the parking spaces reserved for visitors. 

		
	2.2
	LESSEE declares to be aware that the commercial development where the real property contemplated herein is located is composed of several buildings.

		
	2.3
	The offices contemplated herein are duly identified in the attached plans No. 1.04 review 09 and 1.05 review 03 of the executive plan, which, after initialed by the parties, are an integral part hereof as Schedule 1; the parking spaces exclusively reserved for LESSEE shall be delimited by LESSOR in the parking areas near building 3, while the parking spaces for visitors shall be located in the parking areas allocated for such purpose, near the main gate 

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

1

ant at the end of the central court.

		
	2.4
	LESSOR hereby assigns to LESSEE, by means of an exclusively commercial lease, the office spaces described above. During the whole term of effectiveness hereof, LESSOR agrees to (i) guarantee the peaceable possession and use of the Real Property to LESSEE, (ii) be liable for any possible defect in the Real Property. This lease may be extended to other uses, in accordance with the provisions of subsection 2.9. below, if and when required for the activities of LESSEE.

		
	2.5
	LESSOR declares that the Real Property is in good standing in the public agencies and records, completely free and clear of any property, personal, court-ordered or extrajudicial lien, charge, encumbrance, debt, doubt, levy, provisional attachment, sequestration, statutory or conventional mortgage, overdue tax, fee or contribution of any kind, and it hereby agrees to provide the required documents to prove such good standing until delivery of the keys and, afterwards, at the request of LESSEE. LESSEE hereby declares that it is fully aware of the fact that with regard to the Public Records, LESSOR is still performing the required actions to register the construction of the real property in the record of the applicable real estate district. 

		
	2.5.1
	The parties hereby agree that LESSEE shall be solely liable - but it may be assisted by LESSOR to the possible extent - to obtain from the applicable public authorities the operating permit and other authorizations required to its activities at the site, it being understood that LESSOR shall not have any liability in this regard, except with reference to the proper documentation for which it is responsible under Local Law No. 11749, of November 13, 2003, i.e., LESSOR  shall provide: (i) the Plan approved by the Local Government of Campinas with regard to the building; (ii) the Building Permit (iii) a Certificate of Inspection issued by the SANASA, (iv) a Certificate of Inspection issued by the Fire Department, (v) CCO-Certificate of Completion of Works, (vi) copies of the Urban Real Estate Tax (IPTU) payment voucher relating to the unified Lot No. 2 of Block “C” of the Real Estate Development Techno Park Campinas, where the Real Property is located; (vii) updated documents proving ownership of the lot where the Real Property is built (updated certificate of the Real Property record) issued by the competent Register of Deeds. The aforementioned documents shall be provided by LESSOR to LESSEE within up to 30 days after the date of execution hereof. After compliance with the legal requirements as set forth in this section, LESSEE'S possible failure to obtain the required permits shall not be a reason for termination hereof, provided the cases where LESSEE'S failure to obtain the permits results from lack of the documents and actions to be obtained and/or performed by LESSOR.

		
	2.6 
	The office spaces hereby leased shall be delivered by LESSOR to LESSEE in accordance with the original plans, finishing and specifications - as set forth in the aforementioned Schedule 1 - and with the changes requested by LESSEE, as provided in subsections 2.6.1 and 2.6.3 below, which shall be included in a Layout prepared by LESSEE 

2

and which, after approved by LESSOR, shall be an integral part of the Agreement in the form of Schedule 2 (layout). LESSOR shall make these changes within up to 60 days after approval thereof. After completion of these services, the delivery of the real property shall be formalized. Such delivery shall be preceded by an inspection by the parties, on a previously scheduled date and time, on which occasion the parties shall draw up the corresponding instrument of receipt of the keys and applicable annotations on the situation of the Real Property (“Initial Instrument of Inspection”), especially with regard to possible improvements and works carried out by LESSEE that may be removed at the end of the lease, pursuant to the provisions of subsection 8.3.

		
	2.6.1.
	The office spaces' dividing walls shall be removed to create a larger internal space. 

		
	2.6.2.
	The main coating, finishing and installation of the internal areas contemplated in the original plan, as described below, shall not be changed:

		
	i)
	Carpeted raised floor - 12-15 cm;

		
	ii)
	Drywall and acoustic plates;

		
	iii)
	Lamps - type and position;

		
	iv)
	Ducts, position of air supply diffusers and return air filter grilles and individual air conditioning system equipment of each office space.

		
	2.6.3.
	LESSOR shall change, at its expenses, the original configuration of the bathroom facilities, provided the new solution proposed by LESSEE in Schedule 2 - Layout - observes the original position thereof and adopts, in the event of unification of adjacent facilities, the alternative plan developed by LESSOR.

		
	2.6.4.
	The following services and facilities, which shall be planned and carried out for the sole account and risk of LESSEE, are not included in LESSOR'S obligations because they depend on the specific needs of LESSEE:

		
	i)
	Electrical and telecommunications cabling under the raised floor, from the internal power boards of each office space - Circuit Distribution Panel-Type for electrical cabling and Communications Box for telecommunications and data - including installation of the corresponding outlets and connections on the raised floor plates;

		
	ii)
	Internal dividing walls of any kind, including dividing walls between the internal open spaces - OPEN FLOOR - and meeting rooms, executive board rooms, reception, access, data processing and other areas, provided they are not included in the original plan (Schedule 1) and in Schedule 3 mentioned below, it being understood that the suggestions included in presentations and indicative documents prepared by LESSOR shall not be deemed included in the real property. These dividing walls 

3

shall be installed on the raised floor and may not exceed a 300 kg/ml load, and they shall have dimensioned grilles to ensure air conditioning return;
		
	iii)
	Furniture;

		
	iv)
	No-Breaks and/or power stabilizers; and

		
	v)
	Additional equipment of any kind. With regard to air conditioning, LESSOR informs that the units leased hereunder are already equipped with twelve (12) air conditioning units, one in each office space, as well as with the required distribution piping. Should LESSEE wish to install any additional air conditioning unit, LESSEE shall be solely responsible for such installation.

 
		
	2.6.5
	In accordance with the modifications above, which are included in Schedule 2 mentioned in subsection 2.6, LESSOR shall prepare, based on Schedule I, a drawing designated Plan of the Ground Floor and 1st Floor with the basic information for lease of the unified office spaces No. 11B to 16B and 21B to 26B, which, after initialed by the parties, shall be attached hereto as Schedule 3.

		
	2.7. 
	The telecommunications and data transmission facilities contemplated in the original plan, which are made available to LESSEE in each internal communication box, are composed of five metallic pairs per office space.

		
	2.8.
	The wiring demand per office space may not exceed the installed power of the Circuit Distribution Panel-Type of the original wiring plan, which corresponds to 20,080 watts, of which 8,640 watts correspond to the standard air conditioning system and 2,340 watts to the lighting circuits, and a current of 9,100 watts per office space shall be available for the equipment to be installed, totaling 54,600 watts for the six (6) office spaces leased hereunder.

		
	2.8.1
	The electric plan for the internal networks, for which LESSEE shall be responsible in accordance with the provisions of subsection 2.6.4.i above, shall distribute the equipment so that the electric currents installed do not exceed the aforementioned limit per office space, based on the list of equipment and respective rating, the total amount of which shall be compatible with the electric current provided in all office spaces of a given floor, taking into consideration the demand factor and the operation of the additional air conditioning equipment in alternate times and not simultaneously to the operation of the main system.

		
	2.8.2.
	Whenever currents that exceed the amounts contemplated in the original plan are installed in the wiring, LESSEE shall substitute the cables and corresponding circuit breaker, always observing the limit of 20,080 w per Circuit Distribution Panel-Type.

		
	2.9.
	LESSEE declares to be aware that the other office spaces of building “3” and of the other buildings of the development may be occupied by non-disturbing business companies, 

4

service providers and industries, in accordance with the criteria and classifications to be established and defined in the Declaration of Condominium, subject to the limitations imposed by the “Law on the Use and Occupation of Land” of the Local Government of the City of Campinas - Law No. 6031, of December 29, 1988.

		
	2.10
	LESSOR shall provide LESSEE with an electronic file (.plt) containing the original architecture, piping, wiring and telecommunications plan required for the plans for which LESSEE is responsible. LESSEE shall send LESSOR the documents listed below, which relate to the companies and independent contractors hired by LESSEE to execute the finishing, dividing walls, infrastructure networks and other services for which LESSEE is responsible: (i) Technical Responsibility Annotations (ARTs) of the professionals responsible for the plans and works; (ii) complete identification of the legal representative(s); (iii) Environmental Risk Prevention Program (PPRA); (iv) Occupational Health Program (PCMSO); (v) list of the employees involved in the works with identification and number of the social-security card; (vi) copies of the SOCIAL-SECURITY CARD (card identification page, employee identification page, contract page); (vii) Occupational Health Certificate (ASO); (viii) Instrument of Delivery of Individual Protection Equipment (EPI); (ix) Certificate of NR-18 safety training in accordance with the function; (x) in the event of electricians, NR-10 training and, in the event of ditchers, NR-33 training. 

		
	3.
	TERM

		
	3.1
	This lease shall be effective for five (5) years, from November 15, 2011 through November 14, 2016, subject to the provisions of article 4 of Law No. 8245, of October 18, 1991.

		
	3.2
	Taking into consideration the need for sufficient time for installation of the LESSEE, LESSOR shall authorize LESSEE to initiate, for its account and risk, the works relating to the facilities for which it is responsible up to 60 days before final delivery of the office spaces, provided this is technically feasible, it being understood that the office spaces hereby leased shall only be deemed delivered and in the possession of LESSEE upon actual delivery of the keys, along with the documents referred to in subsection 2.5 above, which will occur on November 15, 2011.

		
	3.2.1
	In the event LESSEE fails to timely prepare and deliver to LESSOR the Lay-out (Schedule 2) of its facilities, so that LESSOR has a term of 60 days before the date of commencement of the lease to carry out the works and facilities for which it is responsible, the actual delivery of the keys and signature of the “Instrument of Delivery and Receipt” shall be postponed for a period corresponding to the delay for approval of Schedule 2, without prejudice to the effective date hereof, in case LESSEE is exclusively responsible for this delay.

		
	3.2.2
	The installations for which LESSEE is responsible, which include the responsibilities set forth in subsection 2.6.4 above, may not prevent compliance with the obligations of LESSOR, for which reason its corresponding plans shall be submitted to LESSOR for 

5

approval along with the Lay-out - Schedule 2 - of the facilities.

		
	4.
	RENT

		
	4.1
	The monthly rent hereof is sixty-three thousand four hundred and ninety-five Brazilian reais (R$63,495.00), which LESSEE agrees to pay by the fifth (5th) day of the month following the month of maturity, by means of credit to the checking account held by LESSOR with Banco Bradesco, branch 2002-08, checking account No. 6852-7, or, should there not be any, at the principal business office of LESSOR, during business hours, or at any other address at the discretion of LESSOR.

		
	4.1.1
	The parties agree that the initial term for payment of the rent shall be November 15, 2011, when the real property will be delivered, as set forth in subsection 3.2 above. The first monthly rent shall be due on November 30, 2011, to be paid by LESSEE to LESSOR proportionally to the 15-day period, by December 5, 2011. In case the Real Property is not delivered within the term established in subsection 3.2 above or in case the Real Property is not ready to be received by LESSEE, the initial term set forth in this subsection shall be extended and LESSEE shall have no obligation with regard to the payment of rent, it being understood that the effective date of the Lease and the initial term for the payment of rent shall only commence after actual delivery of the Real Property, by means of actual delivery of the keys and signature of the Instrument of Receipt by LESSEE.

		
	4.2 
	In the event of failure to pay the rent within the term established above, LESSEE shall pay interest at the rate of one percent (1%) per month or fraction of a month, and adjustment for inflation in accordance with the General Market Price Index disclosed by the Getúlio Vargas Foundation (IGP-M FGV), from the maturity date to the date of actual payment, in addition to the payment of a fine corresponding to two percent (2%) of the overdue amount.

		
	4.2.1  
	In the event of failure to pay two consecutive monthly rentals, in addition to the penalties contemplated in subsection 4.2 above, LESSEE shall be subject to the provisions of subsection 13.2 below.

		
	5.
	ADJUSTMENT

		
	5.1
	The monthly rent shall be adjusted annually, after 12 months after execution hereof, by the variation of the IGP-M, as compiled and disclosed by the Getúlio Vargas Foundation, and the reference date shall be August 1st, 2011. Should it not be possible to use this index, for any reason, the following indices shall be adopted, in the following order: Consumer Price Index, as disclosed by the Foundation Institute of Economic Research (IPC/FIPE), Broad Consumer Price Index (IPCA) and General Price Index - Domestic Availability (IGP-DI), or another index that best reflects the inflation of the period, as defined by mutual agreement of the parties.

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	6.
	RESPONSIBILITIES OF LESSEE

		
	6.1
	During the whole term of the lease agreed hereunder, LESSEE shall be solely liable for compliance with the following obligations:

		
	a)
	Payment of the Urban Real Estate Tax (IPTU) and other local fees levied or that come to be levied on the Real Property leased hereunder, i.e., the ideal fractions of land and private and common built areas relating to office spaces 11 B to 16B and 21B to 26B, as well as any other fees charged by the public authorities or public-utility companies with regard to the units that are the subject matter of this lease.

		
	b)
	Payment of the share of the Monthly Contribution Fee relating to Lot 2 of Block C owed to the Techno Park Campinas Owners' Association- ASSOCITECH, which shall be proportional to the private area leased and which refers to the maintenance, management and security and to the payment of fees, charges and taxes relating to the private real estate development Techno Park Campinas.

		
	c)
	Payment of the condominium charges relating to the current expenses with maintenance of the common areas, their buildings and equipment, management, security and payment of fees, charges and taxes relating to the Techno Plaza development or, in the future, Techno Plaza Condominium, proportionally to the private area leased hereunder compared to the total private area of building “3” - which corresponds to fifty percent (50%) - and proportionally to the total private area of building “3” compared to the total private area of the development, which will correspond to 23.8413% when the development is completed. Taking into consideration that the development is being built in phases, its total private area to be taken into consideration shall be the area corresponding to all completed buildings, disregarding those under construction and those that have not been initiated; the applicable rates may be changed upon registration of the condominium, in view of final adjustments in the specifications, which shall be reflected in the plans for the Local Government of the City of Campinas (“occupancy permit”).

		
	d)
	Payment of the share of water (Sanasa) and power (CPFL) consumption and telephone expenses relating to the common facilities of the development, whenever they are not included in the condominium charges referred to above.

		
	e)
	Individual consumption of any kind.

		
	f)
	Share in the expenses with extraordinary maintenance and conservation services for the common areas and facilities of the development and of the corresponding equipment and facilities provided, including, without limitation to, paving, gardens, wiring network and installation, piping and telecommunication systems, pumps and fire protection 

7

equipment, in order to maintain the same conditions of use of operation of new equipment.

		
	g)
	Payment of the share in the annual insurance against fire and liability insurance taken out to cover risks relating to the common buildings and facilities of the development, the amounts of which shall always take into consideration the adjusted costs of the insured assets.

		
	h)
	Payment to LESSOR of the annual insurance premium relating to the insurance directly taken out by LESSOR with a reputable insurance company at market prices, with regard to the private areas involved in this lease, covering the risk of fire, lightning, explosions, windstorms, airplane crashes and civil liability, it being understood that the insured amount shall be based on an amount of up to eighty (80) times the amount of the monthly rent in effect, except if such coverage has already been agreed in the insurance mentioned in the preceding item. The aforementioned liability insurance shall take into consideration the activities carried out at the site. LESSOR agrees to provide LESSEE with a copy of the policy mentioned in this section, which shall inform the contracted coverage and the schedule for payment of the premium.

		
	7.
	TAXES AND FEES

		
	7.1
	During the lease period, LESSEE shall be solely liable to pay the local taxes and fees levied on the real property, even if on a proportional basis, with regard to the office spaces leased hereunder. LESSEE shall not be liable for the payment of taxes and fees levied before the lease, which shall be paid by LESSOR, even if they are assessed in the future. LESSOR agrees to provide LESSEE with the IPTU payment voucher for the current fiscal year, as well as with all other bills that are in its possession, always before the maturity dates, under penalty of being liable for the resulting delinquency fines and charges.

		
	7.2
	The Party that fails to comply with its statutory obligations shall reimburse the aggrieved party for any possible fine imposed by the public authorities as a result of irregularities resulting from actions or failures to act exclusively attributable to one of the Parties.

		
	8.
	CONSERVATION

		
	8.1
	LESSEE agrees to maintain the real property leased hereunder in the same conditions of use as it was received and to return it in the same conditions upon termination hereof, normal wear and tear excepted.

		
	8.1.1
	Except for the changes in the Real Property Layout carried out by LESSOR in accordance with the provisions of subsection 2.6 and items 2.6.1, 2.6.2 and 2.6.3 thereof, LESSOR may, at the end of the lease period, accept return of the real property with all or some of the improvements carried out by LESSEE, subject to the provisions of subsection 8.3 below.

8

		
	8.2
	LESSEE agrees to contract from a company with established technical qualification the preventive and corrective air conditioning maintenance services, so as to guarantee the perfect operation of this equipment during the entire lease period and the good state of conservation thereof at the end of the lease period, normal wear and tear excepted; this company shall be contracted within up to 60 days after the effective date of the lease, and it shall be preliminarily approved or rejected by LESSOR in writing within up to seven (7) business days after presentation of the corresponding technical offer by LESSEE.

		
	8.3
	Except for the works affecting the real property safety, for which LESSOR shall always be solely liable, LESSEE may, with the written consent of LESSOR, make the improvements deemed convenient in the private areas leased hereunder, removing such improvements at the end of the lease period in case LESSOR is not interested in the maintenance and possible acquisition thereof, and whenever such removal does not damage the units themselves and the building where they are located.

		
	9.
	PUBLIC REQUIREMENTS

		
	9.1
	LESSEE shall meet the applicable requirements defined by the Public Authorities and which are directly related to the activities it will carry out in the units that are the subject matter of this lease.

		
	9.2.1
	In the event of expropriation of the real property, wholly or in part, or in case a certain use is prohibited by the competent authorities, this instrument shall be terminated by operation of law and no indemnification shall be owed by one of the parties to the other, provided the right of any of the parties to individually or jointly claim damages to the expropriator.

    
10.    INSPECTIONS

		
	10.1
	LESSOR may examine and inspect the real property leased in business days and hours (i) scheduled five (5) days in advance for routine inspections or (ii) at any time in the event immediate intervention is required, including, without limitation to, in the event of inefficient operation of the facilities, leakage in pipes, wiring problems, inefficient operation of the air conditioning system, structural problems, roof infiltration and others.

		
	10.2
	Should any urgent intervention be required, LESSOR shall orally inform the person specifically designated by LESSEE for such purpose of the urgency, by telephone and even outside normal business hours, and LESSEE shall be required to grant access to its facilities as soon as possible.

9

		
	11.
	ASSIGNMENT AND TRANSFER

		
	11.1
	LESSEE may not assign, transfer, lend or sublease the real property that is the subject matter hereof, wholly or in part, without the express consent of LESSOR, except for companies of the same economic group as LESSEE, it being understood that LESSEE shall remain jointly and fully liable to LESSOR for all obligations hereunder. 

		
	12.
	RECORDS

		
	12.1.
	The parties hereby authorize their respective representatives to promote all required recordation, registrations and filings with the competent registrars for registration of this agreement, and LESSEE shall incur any possible expense in case it is interested in the registration. 

		
	12.2.
	LESSOR shall mention effectiveness of this Agreement in the deed of sale, gift or other instrument of alienation of the Real Property, pursuant to the provisions of article 8 of Law No. 8245/91, to which terms and conditions the future acquirer shall subrogate, it being understood that all terms and conditions of the Agreement shall prevail.

		
	12.2.1
	While the Agreement is not recorded and registered with the competent Register of Deeds, LESSOR shall be required, in the event of alienation of the Real Property, as a prior and essential condition for the possible sale, to enter into an agreement whereby the third parties acquiring the Real Property agree to fully comply with this instrument, under penalty of LESSOR being held liable for damages and contractual penalty.

		
	13.
	FINES

		
	13.1
	The parties agree on a compensatory fine corresponding to three (3) times the rent at the time of the event in the event of violation of any contractual or statutory obligation hereunder, provided such obligation is not complied with within ten (10) business days after the applicable notice. In the event of early return of the real property by LESSEE within a term shorter than the term mentioned in subsection 3.1 above, the fine to be imposed shall also correspond to three (3) times the rent and be reduced proportionally to the term of the lease already elapsed.

		
	13.2
	Subject to the provisions of Subsection 13.1, should any of the parties fail to comply with any of the obligations hereby agreed and to cure such default within the term established in subsection 13.1 above, the innocent party shall be entitled to terminate this instrument by means of written notice, and in addition to the damages possibly owed, the defaulting party shall pay a fine corresponding to three (3) times the monthly rent in effect at the time mentioned in subsection 13.1 above, plus statutory interest and adjustment for inflation.

		
	14.
	GUARANTEE

		
	14.1. 
	In order to guarantee this instrument, LESSEE shall post a bond in an amount corresponding 

10

to three (3) times the monthly rent, which shall be credited to a checking account held by LESSOR and designated for payment of the rent or performance bond agreed with a first class Institution previously approved by LESSOR. Within up to thirty (30) days, LESSEE shall decide for one of the forms of guarantee, performance bond or the posting of bond, and present the insurance policy or post the bond.

Paragraph 1 - The amount of the bond shall be used to guarantee any possible failure to comply with the obligations assumed by LESSEE with regard to the rent and contractual charges during effectiveness hereof. Should such amount be used for compliance with obligations of LESSEE, such amount shall be replenished by LESSEE within up to thirty (30) days after the use thereof, under penalty of termination of this agreement with cause by LESSOR.

Paragraph 2 - After the end of the lease by means of delivery of the keys and subject to the requirements contemplated in this agreement for validity thereof, LESSOR shall return, within at most three (3) business days, the balance of the amount credited with the net yield, i.e., net of the income tax levied in the event of investment in a savings account by legal entities, should it be applicable, calculated in accordance with the Savings Account investment index, less the amounts possibly used and not replenished pursuant to the provisions of paragraph 1 above.

		
	15.
	FINAL PROVISIONS

		
	15.1
	This instrument is irrevocable and irreversible and shall be binding upon the parties, their heirs and successors.

		
	15.2
	No forbearance between the parties with regard to any failure to comply with the obligations assumed hereunder shall constitute a precedent or novation of the provisions hereof, which shall require a written agreement.

		
	 15.3 
	In the event of sale, contract for deed, assignment or commitment to assign rights or accord and satisfaction or any other form of alienation of the real property leased hereunder, LESSEE shall have the right of first refusal to acquire it under the same conditions as third parties. For LESSEE to be able to exercise such right, LESSOR shall give it written notice of all conditions of the transaction it wishes to carry out and the place where and the time when LESSEE may examine the certificates and documents related to such transaction, and LESSOR grant LESSEE a term of no less than thirty (30) days to irrevocably and irreversibly exercise its right of first refusal in writing.

		
	15.4
	All notices, communications or information exchanged between the Parties and addressed to their representatives shall be sent in writing to the addresses identified in the preamble 

11

hereof, unless other addresses have been informed in writing at least ten (10) days in advance.

		
	15.5
	None of the Parties shall be liable for failure to comply with its contractual obligations in the event of act of God or force majeure, pursuant to the provisions of article 393 of the Brazilian Civil Code, for which purpose it shall immediately inform the other Party of the occurrence of such event within up to two (2) days after the event, further informing the adverse effects produced by the event.

		
	15.6
	Any provision of this instrument may only be amended by means of the execution of a written amendment.

		
	15.7
	Notwithstanding any provision to the contrary contained herein, none of the parties, their affiliates and/or employees or representatives shall be held liable to the other party for any indirect damage, loss of profits, loss of revenue, loss of business and others. An example of indirect damage is any damage suffered by LESSOR in a possible loan taken out by LESSOR that results in a penalty for late payment if the amount owed could have been paid had LESSEE not failed to pay the monthly rent hereunder. Another example of indirect damage is any loss suffered by LESSEE as a result of the severance payment to a certain receptionist hired by LESSEE to work in the real property contemplated in this Lease, and whose employment contract had to be terminated as a result of the sale of the real property by LESSOR to third parties. The parties shall only be held liable for indirect damages in case it is established that they have been caused by the parties. 

		
	15.8
	In case any term or provision hereof is held invalid, null, unenforceable or illegal, the remaining terms or provisions shall in no way be affected thereby and shall remain in full force. Should the invalid, illegal or unenforceable provision be deemed an essential element of this Instrument, the Parties shall immediately negotiate valid, legal and enforceable substitutive provisions acceptable to both Parties and which reflect the intent of the Parties with regard to the invalid, illegal or unenforceable provisions.

		
	15.9
	LESSOR may not: a) use this Instrument to guarantee any debt or obligation to third parties. b) issue duplicate invoices with regard to any amount owed hereunder and c) discount or trade any invoice issued by it hereunder in banks, financial institutions, factoring companies or even with individuals.

		
	 15.10
	The parties hereby elect the courts of the Judicial District of the real property to resolve any issue hereunder, provided the parties hereby waive any other court.

IN WITNESS WHEREOF, the parties execute this instrument in three counterparts of equal contents, together with the witnesses identified below.

                

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Campinas, August 10, 2011. 

LESSOR:             /s/ Miguel Gilberto Pascoal
TECHNO PARK EMPREENDIMENTOS E
ADMINISTRAÇÃO IMOBILIÁRIA LTDA.
Miguel Gilberto Pascoal

LESSEE:            /s/ Fabio Schettino    /s/ Mauro Pini França
AMYRIS BRASIL LTDA

    
WITNESSES:

/s/ Ana Paula Souza                    

13

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