Document:

EX-10.10

 Exhibit 10.10 

[####] Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) would be
competitively harmful if publicly disclosed. 
 Execution Version 

License Agreement 
 This Agreement is entered into with
effect as of the Effective Date (as defined below) 
 by and between 

F. Hoffmann-La Roche Ltd 

with an office and place of business at Grenzacherstrasse 124, 4070 Basel, Switzerland (“Roche Basel”) 

and 

Hoffmann-La Roche Inc. 

with an office and place of business at 150 Clove Road, Suite 8, Little Falls, New Jersey 07424, U.S.A. (“Roche US”; Roche Basel and Roche US
together referred to as “Roche”) 
 on the one hand 

and 
 PEGA-ONE SAS 

(RCS number 853 093 458 Creteil) with an office and place of business at 1 Mail du Professeur Georges Malthe, Villejuif
Bio-Park, 94800 Villejuif, France (“PEGA1”) on the other hand. 

 TABLE OF CONTENTS 

 

									
	 	  	 	    	 	  	Page	 
			
	1.	  	Definitions	  	 	1	 
				
		  	1.1	    	Affiliate	  	 	1	 
				
		  	1.2	    	Agreement	  	 	2	 
				
		  	1.3	    	Agreement Term	  	 	2	 
				
		  	1.4	    	Applicable Law	  	 	2	 
				
		  	1.5	    	Business Day	  	 	2	 
				
		  	1.6	    	Calendar Quarter	  	 	2	 
				
		  	1.7	    	Calendar Year	  	 	2	 
				
		  	1.8	    	Change of Control	  	 	2	 
				
		  	1.9	    	Change of Control Group	  	 	3	 
				
		  	1.10	    	Clinical Batch	  	 	3	 
				
		  	1.11	    	Clinical Study	  	 	3	 
				
		  	1.12	    	Closing Date	  	 	3	 
				
		  	1.13	    	Combination Product	  	 	3	 
				
		  	1.14	    	Commercially Reasonable Efforts	  	 	3	 
				
		  	1.15	    	Compound	  	 	4	 
				
		  	1.16	    	Confidential Information	  	 	4	 
				
		  	1.17	    	Continuation Election Notice	  	 	4	 
				
		  	1.18	    	Control	  	 	4	 
				
		  	1.19	    	Cover	  	 	5	 
				
		  	1.20	    	Data Room	  	 	5	 
				
		  	1.21	    	Development Plan	  	 	5	 
				
		  	1.22	    	Development Program	  	 	5	 
				
		  	1.23	    	Drug Approval Application	  	 	5	 
				
		  	1.24	    	Effective Date	  	 	5	 
				
		  	1.25	    	Europe	  	 	5	 
				
		  	1.26	    	Expert	  	 	5	 
				
		  	1.27	    	FDA	  	 	6	 
				
		  	1.28	    	FDCA	  	 	6	 
				
		  	1.29	    	Field	  	 	6	 

  
 -i- 

 TABLE OF CONTENTS 

(continued) 
  

									
	 	  	 	    	 	  	Page	 
				
		  	1.30	    	Filing	  	 	6	 
				
		  	1.31	    	First Commercial Sale	  	 	6	 
				
		  	1.32	    	GAAP	  	 	6	 
				
		  	1.33	    	Generic Product	  	 	6	 
				
		  	1.34	    	Handle	  	 	7	 
				
		  	1.35	    	Housemark	  	 	7	 
				
		  	1.36	    	IFRS	  	 	7	 
				
		  	1.37	    	IND	  	 	7	 
				
		  	1.38	    	Indication	  	 	7	 
				
		  	1.39	    	Initiation	  	 	7	 
				
		  	1.40	    	Insolvency Event	  	 	7	 
				
		  	1.41	    	Invention	  	 	8	 
				
		  	1.42	    	IPO	  	 	8	 
				
		  	1.43	    	IPO Effective Time	  	 	8	 
				
		  	1.44	    	Joint Know-How	  	 	8	 
				
		  	1.45	    	Joint Patent Rights	  	 	8	 
				
		  	1.46	    	Know-How	  	 	8	 
				
		  	1.47	    	Lonza Agreement	  	 	9	 
				
		  	1.48	    	Net Sales	  	 	9	 
				
		  	1.49	    	Partner	  	 	10	 
				
		  	1.50	    	Partner Agreement	  	 	10	 
				
		  	1.51	    	Party	  	 	10	 
				
		  	1.52	    	Patent Rights	  	 	10	 
				
		  	1.53	    	PEGA1 Know How	  	 	11	 
				
		  	1.54	    	PEG A1 Patent Rights	  	 	11	 
				
		  	1.55	    	Phase I Study	  	 	11	 
				
		  	1.56	    	Phase II Study	  	 	11	 
				
		  	1.57	    	Phase III Study	  	 	11	 
				
		  	1.58	    	Pivotal Study	  	 	11	 
				
		  	1.59	    	Private Financing	  	 	11	 

  
 -ii- 

 TABLE OF CONTENTS 

(continued) 
  

									
	 	  	 	    	 	  	Page	 
				
		  	1.60	    	Proceeds	  	 	12	 
				
		  	1.61	    	Product	  	 	12	 
				
		  	1.62	    	Regulatory Approval	  	 	12	 
				
		  	1.63	    	Regulatory Authority	  	 	12	 
				
		  	1.64	    	Regulatory Documentation	  	 	12	 
				
		  	1.65	    	Regulatory Exclusivity	  	 	12	 
				
		  	1.66	    	Roche Glycoengineering Technology Patent Rights	  	 	13	 
				
		  	1.67	    	Roche Know-How	  	 	13	 
				
		  	1.68	    	Roche Patent Rights	  	 	13	 
				
		  	1.69	    	Royalty Term	  	 	13	 
				
		  	1.70	    	Sublicensees	  	 	13	 
				
		  	1.71	    	Strategic Transaction	  	 	13	 
				
		  	1.72	    	Successful Manufacture	  	 	13	 
				
		  	1.73	    	Territory	  	 	13	 
				
		  	1.74	    	Third Party	  	 	14	 
				
		  	1.75	    	US	  	 	14	 
				
		  	1.76	    	US$	  	 	14	 
				
		  	1.77	    	Valid Claim	  	 	14	 
				
		  	1.78	    	Additional Definitions	  	 	14	 
			
	2.	  	Grant of License	  	 	16	 
				
		  	2.1	    	Exclusive License	  	 	16	 
				
		  	2.2	    	Lonza Sublicense	  	 	16	 
				
		  	2.3	    	Right to Sublicense to Affiliates	  	 	17	 
				
		  	2.4	    	Right to enter into Partner Agreements	  	 	17	 
				
		  	2.5	    	Sub-Contractors	  	 	18	 
				
		  	2.6	    	Retained Rights	  	 	18	 
			
	3.	  	Right of First Negotiation	  	 	18	 
				
		  	3.1	    	Due Diligence	  	 	18	 
				
		  	3.2	    	Grant of Rights	  	 	18	 
				
		  	3.3	    	Process	  	 	19	 

  
 -iii- 

 TABLE OF CONTENTS 

(continued) 
  

									
	 	  	 	    	 	  	Page	 
				
		  	3.4	    	Consequences of termination of this Agreement	  	 	20	 
			
	4.	  	Alliance Managers and Technology Transfer	  	 	20	 
				
		  	4.1	    	Alliance Managers	  	 	20	 
				
		  	4.2	    	Roche Know-How Transfer	  	 	20	 
				
		  	4.3	    	Transfer of CMC materials	  	 	21	 
				
		  	4.4	    	Further Obligations	  	 	21	 
			
	5.	  	Diligence	  	 	21	 
			
	6.	  	Development	  	 	21	 
				
		  	6.1	    	Responsibility	  	 	21	 
				
		  	6.2	    	Development Plan	  	 	21	 
				
		  	6.3	    	Reporting	  	 	21	 
				
		  	6.4	    	Right of Reference	  	 	22	 
			
	7.	  	Supply	  	 	22	 
				
		  	7.1	    	Clinical and Non-Clinical Supply of Product	  	 	22	 
				
		  	7.2	    	Commercial Supply of Product	  	 	22	 
			
	8.	  	Regulatory	  	 	22	 
				
		  	8.1	    	Responsibility	  	 	22	 
				
		  	8.2	    	Informed Consent Forms	  	 	23	 
				
		  	8.3	    	Pharmacovigilance Agreement	  	 	23	 
			
	9.	  	Commercialization	  	 	23	 
				
		  	9.1	    	Responsibility	  	 	23	 
				
		  	9.2	    	Reporting and Updates	  	 	23	 
			
	10.	  	Payment	  	 	24	 
				
		  	10.1	    	Upfront Payment	  	 	24	 
				
		  	10.2	    	Development Event Payments	  	 	24	 
				
		  	10.3	    	Sales Based Events	  	 	24	 
				
		  	10.4	    	Royalty Payments	  	 	25	 
				
		  	10.5	    	Combination Product	  	 	26	 
				
		  	10.6	    	Expert Committee	  	 	27	 
				
		  	10.7	    	Strategic Transaction	  	 	27	 

  
 -iv- 

 TABLE OF CONTENTS 

(continued) 
  

									
	 	  	 	    	 	  	Page	 
				
		  	10.8	    	IPO	  	 	29	 
				
		  	10.9	    	Third Party Payments	  	 	30	 
			
	11.	  	Accounting and reporting	  	 	30	 
				
		  	11.1	    	Timing of Payments	  	 	30	 
				
		  	11.2	    	Late Payment	  	 	30	 
				
		  	11.3	    	Method of Payment	  	 	30	 
				
		  	11.4	    	Currency Conversion	  	 	30	 
				
		  	11.5	    	Reporting	  	 	30	 
			
	12.	  	Taxes	  	 	31	 
			
	13.	  	Auditing	  	 	31	 
				
		  	13.1	    	Roche Right to Audit	  	 	31	 
				
		  	13.2	    	Audit Reports	  	 	32	 
				
		  	13.3	    	Over-or Underpayment	  	 	32	 
			
	14.	  	Intellectual Property	  	 	32	 
				
		  	14.1	    	Ownership of Inventions and Know-How	  	 	32	 
				
		  	14.2	    	German Statute on Employee’s Inventions	  	 	33	 
				
		  	14.3	    	Trademarks	  	 	33	 
				
		  	14.4	    	Prosecution of Roche Patent Rights	  	 	33	 
				
		  	14.5	    	Prosecution of PEGA1 Patent Rights and Joint Patent Rights	  	 	34	 
				
		  	14.6	    	Patent Coordination Team	  	 	34	 
				
		  	14.7	    	Abandonment of Patent Rights	  	 	34	 
				
		  	14.8	    	Infringement	  	 	34	 
				
		  	14.9	    	Defense	  	 	36	 
				
		  	14.10	    	Common Interest Disclosures	  	 	36	 
				
		  	14.11	    	Patent Term Extensions	  	 	36	 
			
	15.	  	Representations and Warranties (Zugesicherte Eigenschaften)	  	 	37	 
				
		  	15.1	    	Mutual representations and warranties	  	 	37	 
				
		  	15.2	    	PEGA1 representations and warranties	  	 	37	 
				
		  	15.3	    	Roche Representations and Warranties	  	 	37	 
				
		  	15.4	    	Disclaimer	  	 	38	 

  
 -v- 

 TABLE OF CONTENTS 

(continued) 
  

									
	 	  	 	    	 	  	Page	 
			
	16.	  	Indemnification	  	 	38	 
				
		  	16.1	    	Roche indemnification	  	 	38	 
				
		  	16.2	    	PEGA1 indemnification	  	 	38	 
				
		  	16.3	    	Procedure	  	 	38	 
			
	17.	  	Liability	  	 	39	 
				
		  	17.1	    	Disclaimer	  	 	39	 
				
		  	17.2	    	Limitation of Liability	  	 	39	 
			
	18.	  	Obligation Not to Disclose Confidential Information	  	 	39	 
				
		  	18.1	    	Non-Use and Non-Disclosure	  	 	39	 
				
		  	18.2	    	Permitted Disclosure	  	 	39	 
				
		  	18.3	    	Press Releases	  	 	40	 
				
		  	18.4	    	Publications	  	 	40	 
				
		  	18.5	    	Commercial Considerations	  	 	40	 
			
	19.	  	Term and Termination	  	 	41	 
				
		  	19.1	    	Commencement and Term	  	 	41	 
				
		  	19.2	    	Termination	  	 	41	 
				
		  	19.3	    	Termination for Breach	  	 	41	 
				
		  	19.4	    	Termination for Insolvency Event	  	 	41	 
				
		  	19.5	    	Termination by PEGA1 without a Cause	  	 	41	 
				
		  	19.6	    	Consequences of Termination	  	 	42	 
				
		  	19.7	    	Termination by PEGA1 for Breach by Roche or Roche Insolvency	  	 	42	 
				
		  	19.8	    	Termination by PEGA1 without cause, termination by Roche for Breach	  	 	42	 
				
		  		    	by PEGA1, PEGA1 Insolvency or PEGA1 Debarment	  			
				
		  	19.9	    	Obligations Related to Ongoing Activities	  	 	43	 
				
		  	19.10	    	Obligations Related to Manufacturing	  	 	43	 
				
		  	19.11	    	Ancillary Agreements	  	 	44	 
				
		  	19.12	    	Direct License	  	 	44	 
				
		  	19.13	    	Royalty and Payment Obligations	  	 	44	 
				
		  	19.14	    	Survival	  	 	44	 
			
	20.	  	Bankruptcy	  	 	45	 

  
 -vi- 

 TABLE OF CONTENTS 

(continued) 
  

									
	 	  	 	    	 	  	Page	 
			
	21.	  	Miscellaneous	  	 	45	 
				
		  	21.1	    	Governing Law and Jurisdiction	  	 	45	 
				
		  	21.2	    	Disputes	  	 	45	 
				
		  	21.3	    	Insurance	  	 	45	 
				
		  	21.4	    	Assignment	  	 	45	 
				
		  	21.5	    	Debarment	  	 	46	 
				
		  	21.6	    	Independent Contractor	  	 	46	 
				
		  	21.7	    	Unenforceable Provisions and Severability	  	 	46	 
				
		  	21.8	    	Waiver	  	 	46	 
				
		  	21.9	    	Appendices	  	 	46	 
				
		  	21.10	    	Interpretation	  	 	47	 
				
		  	21.11	    	Invoices	  	 	47	 
				
		  	21.12	    	Notice	  	 	47	 
				
		  	21.13	    	Condition Precedent	  	 	48	 

  
 -vii- 

 License Agreement 

WHEREAS, Roche has discovered and has conducted certain research and development related to, and possesses certain intellectual property with respect to the
glycoengineered anti-EGFR mAB Imgatuzumab (RO5083945) also referred to as GA201 (“Compound” as further defined below); and 
 WHEREAS, PEGA1 has
the resources and expertise in the development, manufacturing and commercialization of pharmaceutical products; and 
 WHEREAS, PEGA1 desires to obtain, and
Roche is willing to grant to PEGA1 an exclusive, royalty-bearing license to develop, manufacture and commercialize Compound and Products in the Field in the Territory (terms as defined below), subject to the terms and conditions hereof; and 

NOW, THEREFORE, in consideration of the mutual covenants and promises contained in this Agreement and other good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, the Parties hereto, intending to be legally bound, do hereby agree as follows; 
  

	1.	 Definitions 

As used in this Agreement, the following terms, whether used in the singular or plural, shall have the following meanings: 

1.1 Affiliate  
 The term
“Affiliate” shall mean any individual, corporation, association or other business entity that directly or indirectly controls, is controlled by, or is under common control with the Party in question. As used in this definition of
“Affiliate,” the term “control” shall mean the direct or indirect ownership of more than fifty percent (>50%) of the stock having the right to vote for directors thereof or the ability to otherwise control the management of
the corporation or other business entity whether through the ownership of voting securities, by contract, resolution, regulation or otherwise. Anything to the contrary in this paragraph notwithstanding, Chugai Pharmaceutical Co., Ltd, a Japanese
corporation (“Chugai”) not be deemed as Affiliate of Roche unless Roche provides written notice to PEGA1 of its desire to include Chugai, and/or their respective subsidiaries (as applicable) as Affiliate(s) of Roche. In respect of
PEGA1, Affiliate excludes any investor, venture capital fund, venture capital trust, private equity group, pension fund, investment trust or similar sources of capital. 

1.2 Agreement  
 The term
“Agreement” shall mean this document including any and all appendices and amendments to it as may be added and/or amended from time to time in accordance with the provisions of this Agreement. 

  
 1 

 1.3 Agreement Term  

The term “Agreement Term” shall mean the period of time commencing on the Effective Date and, unless this Agreement is terminated sooner as provided
in Article 20, expiring on the date when no royalty or other payment obligations under this Agreement are or will become due. 
 1.4
Applicable Law  
 The term “Applicable Law’’ shall mean any law, statute, ordinance, code, rule or regulation that has been enacted by
a government authority (including without limitation, any Regulatory Authority) and is in force as of the Effective Date or comes into force during the Agreement Term, in each case to the extent that the same are applicable to the performance by the
Parties of their respective obligations under this Agreement. 
 1.5 Business Day  

The term “Business Day” shall mean 9.00am to 5.00pm local time on a day other than a Saturday, Sunday or bank or other public or federal holiday in
Switzerland or France. 
 1.6 Calendar Quarter  

The term “Calendar Quarter’’ shall mean each period of three (3) consecutive calendar months, ending March 31, June 30,
September 30, and December 31. 
 1.7 Calendar Year  

The term “Calendar Year’’ shall mean the period of time beginning on January 1 and ending December 31, except for the first year which
shall begin on the Effective Date and end on December 31. 
 1.8 Change of Control  

The term “Change of Control” shall mean, with respect to a Party: (a) the acquisition by one or more Third Parties of beneficial ownership of
fifty percent (50%) or more of the then outstanding common shares or voting power of such Party, other than acquisitions by employee benefit plans sponsored or maintained by such Party; (b) the consummation of a business combination involving
such Party, unless, following such business combination, the stockholders of such Party that owned directly or indirectly more than fifty percent (50%) of the then outstanding common shares or voting power of the entity immediately prior to such
business combination beneficially own directly or indirectly more than fifty percent (50%) of the then outstanding common shares or voting power of the entity resulting from such business combination; or (c) the sale of all or substantially all
of such Party’s assets or business relating to the subject matter of the Agreement. Notwithstanding the foregoing, (i) the consummation of an IPO by PEGA1 shall not be deemed a Change of Control of PEGA1 and (ii) a Change of Control
shall not include a Private Financing. 

  
 2 

 1.9 Change of Control Group  

The term “Change of Control Group” shall mean with respect to a Party, the person or entity, or group of persons or entities, that is the acquirer
of, or a successor to, a Party in connection with a Change of Control, together with affiliates of such persons or entities that are not Affiliates of such Party immediately prior to the completion of such Change of Control of such Party. 

1.10 Clinical Batch  
 The term
“Clinical Batch” shall mean the first batch of Product, manufactured by or on behalf of PEGA 1, suitable to be used for Clinical Studies according to specifications accepted by Regulatory Authorities. 

1.11 Clinical Study  
 The term
“Clinical Study” shall mean a Phase I Study or Phase II Study or Phase Ill Study, as applicable. 
 1.12 Closing Date  

The term “Closing Date” shall mean the date on which the Condition Precedent has been satisfied. 

1.13 Combination Product  
 The term
“Combination Product” shall mean 
  

	 	a)	 a single pharmaceutical formulation containing as its active pharmaceutical ingredients both the Compound and
one or more other therapeutically or prophylactically active pharmaceutical ingredients, or 

  

	 	b)	 a combination therapy comprised of the Compound and one or more other therapeutically or prophylactically
active products, priced and sold in a single package containing such multiple products or packaged separately but sold together for a single price, 

in each case, including all dosage forms, formulations, presentations, line extensions, and package configurations. All references to Product in this Agreement
shall be deemed to include Combination Product. 
 1.14 Commercially Reasonable Efforts  

The term “Commercially Reasonable Efforts” shall mean, with respect to PEGA1’s obligation under this Agreement to develop or commercialize
Product, the level of efforts required to carry out such obligation in a sustained manner consistent with the efforts a similarly situated biopharmaceutical company or pharmaceutical company, as the case may be, devotes to products of similar stage
of development, product life, market potential, profit potential, safety and efficacy, scientific potential and strategic value resulting from its own research efforts, based on conditions then prevailing, taking into consideration the market,
exclusivity and other conditions in particular markets of the Territory. However, Commercially Reasonable Efforts does not always require PEGA1 to seek to market Products in every country or seek to obtain Regulatory Approval in every country or for
every potential Indication. 

  
 3 

 1.15 Compound  

The term “Compound” shall mean the glycoengineered anti-EGFR monoclonal antibody imgatuzumab also referred to as GA201 or RO5083945 as specified in
World Health Organisation Drug Information Vol. 27, No. 1,2013, pp. 62-63. 
 1.16
Confidential Information  
 The term “Confidential Information” shall mean any and all information, data or
know-how (including Know-How), whether technical or non-technical, oral or written, that is disclosed by one Party or its
Affiliates (“Disclosing Party”) to the other Party or its Affiliates (“Receiving Party”). Confidential Information shall not include any information, data or know-how that:

 (i) was generally available to the public at the time of disclosure, or information that becomes available to the public after disclosure by the
Disclosing Party other than through fault (whether by action or inaction) of the Receiving Party or its Affiliates, 
 (ii) can be evidenced by written
records to have been already known to the Receiving Party or its Affiliates prior to its receipt from the Disclosing Party, 
 (iii) is obtained at any
time lawfully from a Third Party under circumstances permitting its use or disclosure, 
 (iv) is developed independently by the Receiving Party or its
Affiliates as evidenced by written records other than through knowledge of Confidential Information, 
 (v) is approved in writing by the Disclosing
Party for release by the Receiving Party, The terms of this Agreement shall be considered Confidential Information of the Parties. 
 1.17
Continuation Election Notice  
 The term “Continuation Election Notice” shall mean the notice Roche provides to PEGA1 under
Section 19.8. 
 1.18 Control  

The term “Control” shall mean (as an adjective or as a verb including conjugations and variations such as “Controls” “Controlled”
or “Controlling”) (a) with respect to Patent Rights and/or Know- How, the possession by a Party of the ability to grant a license or sublicense of such Patent Rights and/or Know-How (i) without
violating the terms of any agreement or arrangement between such Party and any other party or (ii) without requiring the payment of any additional consideration from such Party to any other party, and (b) with respect to proprietary
materials, the possession by a Party of the ability to supply such proprietary materials to the other Party as provided herein without violating the terms of any agreement or arrangement between such Party and any other party. 

  
 4 

 1.19 Cover  

The term “Cover” shall mean (as an adjective or as a verb including conjugations and variations such as “Covered,” “Coverage” or
“Covering”) that the developing, making, using, offering for sale, promoting, selling, exporting or importing of a given compound, formulation or product would infringe a Valid Claim in the absence of a license under the Patent Rights to
which such Valid Claim pertains. The determination of whether a compound, formulation, process or product is Covered by a particular Valid Claim shall be made on a
country-by-country basis. 
 1.20 Data Room  

The term “Data Room” shall mean the due diligence data room containing all material data and information, including but not limited to PEGA1 Patent
Rights, Joint Patent Rights, clinical data, regulatory correspondence, and Chemistry, Manufacturing, and Controls (“CMC”) data related to the Compound and/or Products generated by PEGA1 after the Effective Date. 

1.21 Development Plan  
 The term
“Development Plan” shall mean the plan for the development of the Products as set forth in Section 6.2. 
 1.22
Development Program  
 The term “Development Program” shall mean the activities undertaken by PEGA1 pursuant to the Development Plan to
develop Compound and Products, and such other activities with regard to Compound and Products as the Parties may agree in writing 
 1.23
Drug Approval Application  
 The term Drug Approval Application shall mean an application for Regulatory Approval for the Products for use in the
Field submitted to the FDA, or a foreign equivalent of the FDA. 
 1.24 Effective Date  

The term “Effective Date” shall mean the Closing Date. 

1.25 Europe  
 The term “Europe”
shall mean the organization of member states known as the European Economic Area, as its membership may be altered from time to time, and any successor thereto, and all of its then current member countries and in any event the United Kingdom and
Switzerland. 
 1.26 Expert  
 The term
“Expert” shall mean a person with no less than [####] of pharmaceutical industry experience and expertise having occupied at least one senior position within a large pharmaceutical company relating to product commercialization and/or
licensing but excluding any current or former employee or consultant of either Party. Such person shall be fluent in the English language. 

  
 5 

 1.27 FDA  

The term “FDA” shall mean the Food and Drug Administration of the United States of America or any successor agency thereto. 

1.28 FDCA  
 The term “FDCA”
shalt mean the Food, Drug and Cosmetics Act, as amended, and the rules and regulations promulgated thereunder. 
 1.29 Field  

The term “Field” shall mean all Indications and uses in humans, excluding diagnostic uses. 

1.30 Filing  
 The term “Filing”
shall mean the filing of an application to the FDA as defined in the FDCA and applicable regulations, or the equivalent application to the equivalent agency in any other country or group of countries, the official approval of which is required
before any lawful commercial sale or marketing of Products. 
 1.31 First Commercial Sale  

The term “First Commercial Sale” shall mean, with respect to a Product in any country, the first invoiced sale of such Product to a Third Party by
PEGA 1 (or, if applicable its Affiliates or Sublicensees) in such country following the receipt of any Regulatory Approval required for the sale of such Product, or if no such Regulatory Approval is required, the date of the first invoiced sale of a
Product to a Third Party by PEGA 1 (or, if applicable, its Affiliates or Sublicensees) in such country. For clarity, compassionate use sales will not be considered in determining the First Commercial Sale. 

1.32 GAAP  
 The term “GAAP”
shall mean Generally Accepted Accounting Principles. 
 1.33 Generic Product  

The term “Generic Product” shall mean with respect to a Product in a country in the Territory, any other prescription pharmaceutical product
including biosimilar (i) that is introduced in the Territory by a Third Party who did not purchase such product in a chain of distribution that included any of PEGA 1, its Affiliates or Sublicensees, (ii) contains the same active
ingredient(s) as such Product, and (iii) for which Regulatory Approval is obtained by an abbreviated Drug Approval Application or other abbreviated pathway not requiring the filing of a complete Drug Approval Application or comparable
registration application under Applicable Laws of the FDA or any other applicable Regulatory Authority. 

  
 6 

 1.34 Handle  

The term “Handle” shall mean with respect to Patent Rights preparing, filing, prosecuting (including interference and opposition proceedings) and
maintaining (including payment or maintenance fees and annuities and overseeing interferences, proceedings, reissue applications and proceedings, re-examination applications and proceedings, post-grant
reviews, inter-partes reviews, derivation proceedings and opposition proceedings). 
 1.35 Housemark  

The term “Housemark” shall mean the names of Roche or its Affiliates, or variations of the names, and all related logotypes and symbols used by Roche
or its Affiliates in connection with its products and/or services. 
 1.36 IFRS  

The term “IFRS” shall mean International Financial Reporting Standards. 

1.37 IND  
 The term “IND” shall
mean an Investigational New Drug application as defined in the FDCA and applicable regulations promulgated by the FDA, or the equivalent application to the equivalent agency in any other country or group of countries, the filing of which is
necessary to commence clinical testing of a Product in humans. 
 1.38 Indication  

The term “Indication” shall mean any indication classified as a separate block of a three-character category in the Tenth Revision of the
International Classifications of Diseases and Related Health Problems (“ICD-10”). 
 1.39 Initiation  

The term “Initiation” shall mean the date the first human is dosed with the Product in a Clinical Study approved by the respective Regulatory
Authority. 
 1.40 Insolvency Event  

The term “Insolvency Event” shall mean circumstances under which a Party (i) has a receiver or similar officer appointed by a court of competent
jurisdiction or governmental authority over all or a material part of its assets or undertaking; (ii) passes a resolution for winding-up (other than a winding-up
for the purpose of, or in connection with, any solvent amalgamation or reconstruction) or a court makes an order to that effect or a court makes an order for administration (or any equivalent order in any jurisdiction); (iii) enters into any
composition or arrangement with its creditors (other than relating to a solvent restructuring); (iv) ceases to carry on business; or (v) is unable to pay its debts as they become due in the ordinary course of business. 

  
 7 

 1.41 Invention  

The term “Invention” shall mean an invention that is conceived or reduced to practice in connection with any activity carried out pursuant to this
Agreement. Under this definition, an Invention may be made by employees of PEGA 1, including any improvement to the Roche Patent Rights, Roche Know How or a Roche Invention, solely or jointly with a Third Party (a “PEGA1 Invention”),
by employees of Roche solely or jointly with a Third Party (a “Roche Invention”), or jointly by employees of PEGA 1 and Roche with or without a Third Party (a “Joint Invention”). This notwithstanding, any
improvement to the Roche Glycoengineering Technology Patent Rights (as listed in Appendix 1.65) shall be a Roche Invention~ 
 1.42 IPO
 
 The term “IPO” shall mean, with respect to PEGA 1, (i) PEGA 1’ s first underwritten public offering of its common stock under the
Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder, or with respect to any non-US public offering, under any foreign equivalent (a “Traditional IPO”), or
(ii) a “reverse merger” of PEGA1 prior to its first underwritten public offering with and into a Third Party publicly traded company (a “Reverse Merger” and such entity, the “Public Target”).

 1.43 IPO Effective Time  
 The term
“IPO Effective Time” shall mean, with respect to PEGA1’s IPO, the time point at which either (i) in the case of a Traditional IPO, PEGA1’s registration statement on Form S-1 (or
equivalent document) is declared effective by the US Securities and Exchange Commission (or, with respect to any non-US public offering, any equivalent agency or other responsible party) and shares of
PEGA1’s common stock become available for public trade, or (ii) in the case of a Reverse Merger, the closing of any Reverse Merger occurs. 

1.44 Joint Know-How  

The term “Joint Know-How” shall mean Know-How that is made jointly by
the Parties or their Affiliates or their Sublicensees in connection with any activity carried out pursuant to this Agreement. 
 1.45
Joint Patent Rights  
 The term “Joint Patent Rights” shall mean all Patent Rights Covering a Joint Invention. 

1.46 Know-How  

The term “Know-How” shall mean data, knowledge and information, including materials, samples, chemical
manufacturing data, toxicological data, pharmacological data, preclinical data, proprietary assays related to the Compound, platforms, formulations, specifications, quality control testing data, that are necessary for the research, manufacture,
development or commercialization of Compound or Products. 

  
 8 

 1.47 Lonza Agreement  

The term “Lonza Agreement’ shall mean the restated umbrella research and license agreement between Lonza Sales AG and Roche dated 29 November
2013, as amended now or in the future a copy of which (with reasonable redactions) is attached hereto as Appendix 2.2, and incorporated herein by reference. 

1.48 Net Sales  
 The term “Net
Sales” shall mean, for a Product in a particular period, the sum of (i) and (ii): 
  

	(i)	 the gross invoiced sales at which such Product was sold or otherwise disposed of by PEGA1 and its Affiliates to
such Third Parties (excluding sales to any Sublicensees that are not Affiliates of PEGA1, unless these Sublicensees are the final end-user along with any sales for clinical purposes arising before First
Commercial Sale, compassionate uses, humanitarian and charitable donations) in such period reduced by gross-to-net deductions, if not previously deducted from such
invoiced amount, taken in accordance with the then currently used IFRS or GAAP, as applicable. 

 By way of example, the gross-to-net deductions taken in accordance with IFRS as of the Effective Date include the following: 
  

	 	(a)	 credits, reserves or allowances granted for (i) damaged, outdated, returned, rejected, withdrawn or
recalled Product, (ii) wastage replacement and short-shipments; (iii) billing errors and (iv) indigent patient and similar programs (e.g., price capitation); 

 

	 	(b)	 governmental price reductions and government mandated rebates; 

 

	 	(c)	 chargebacks, including those granted to wholesalers, buying groups and retailers; 

 

	 	((d)	 freight, postage charges, transportation insurance, packing materials for dispatch of goods and custom duties;

  

	 	(e)	 customer rebates, including cash sales incentives for prompt payment, cash and volume discounts; and

  

	 	(f)	 taxes and any other governmental charges or levies imposed upon or measured by the use, manufacture or sale of
a Product (excluding income or franchise taxes) and other government charges accrued during such period, including, for example, any fees, taxes or other charges that become due in connection with any healthcare reform, change in government pricing
or discounting schemes, or other action of a government or regulatory body. 

  

	(ii)	 for Sublicensees that are not Affiliates of PEGA1 the sales amounts reported to PEGA1 and its Affiliates in
accordance with this Agreement and their then-currently used IFRS or GAAP. For purposes of clarity, sales by PEGA1 and its Affiliates to any Sublicensees shall be excluded from “Net Sales” unless the Sublicensees is the final end-user. 

  
 9 

 In the event that the Compound is sold in any country in the form of a Combination Product, Net sales of
such Combination Product shall be adjusted by the fraction (A)/(A+B) where A is the average invoice price of the Product that is not a Combination Product in such country and B the average invoice price in such country of each product that contains
active ingredient(s) other than the Compound. If either the Product that is not a Combination Product or the other product(s) is not sold separately in a particular country, the Parties shall negotiate in good faith a reasonable adjustment to Net
Sales in such country that takes into account the medical contribution to the Combination Product of an all other factors reasonably relevant to the relative value of, the Compound, on the one hand and all the other active ingredient(s),
collectively, on the other hand. 
 Where any discount or rebate is based on sales of a bundled set of products in which a Product is included, the discount
or rebate shall be allocated to such Product on a pro rata basis based on the list sales value (i.e. the unit list price multiplied by the unit volume) of the Product relative to the list sales value contributed by the other products in the bundled
set with respect to such sale. 
 1.49 Partner  

The term “Partner” shall mean a Third Party with which PEGA1 will enter or has entered (as applicable) a Partner Agreement. 

1.50 Partner Agreement  
 The term
“Partner Agreement” shall mean any agreement between PEGA1 and a Third Party pursuant to Section 2.4 granting rights to develop (but excluding co-development agreements that do not include
commercial rights) and/or commercialize the Compound and/or the Product (including but not limited to a (i) sub-license agreement with a Third Party, (ii) merger, acquisition, sale, transfer or other
transaction involving the Compound and/or the Product (but for clarity, excluding a Change of Control), or (iii) an assignment of this Agreement to a Third Party that is not done in connection with a Change of Control) in one or more countries
of the Territory, other than a sub-contract pursuant to Section 2.5. 
 1.51 Party  

The term “Party” shall mean PEGA1 or Roche, as the case may be, and “Parties” shall mean PEGA1 and Roche collectively. 

1.52 Patent Rights  
 The term
“Patent Rights” shall mean all rights under any patent or patent application, certificate of invention, application for certificate of invention or priority patent filing in any country of the Territory or under any international
convention or treaty, including any patents issuing on such patent application, and further including any substitution, extension or supplementary protection certificate, reissue, reexamination, renewal, division, continuation or continuation-in-part of any of the foregoing. 

  
 10 

 1.53 PEGA1 Know How  

The term “PEGA1 Know-How” shall mean the Know-How (other than Joint Know-How) that PEGA1 Controls at the Effective Date and during the Agreement Term. 
 1.54 PEG A1
Patent Rights  
 The term “PEGA1 Patent Rights” shall mean the Patent Rights (other than the Joint Patent Rights) that PEGA1 Controls,
relating to or arising from the research, manufacture, development or commercialization of or Covering a Product. 
 1.55 Phase I Study
 
 The term “Phase I Study” shall mean a human clinical trial in any country that would satisfy the requirements of 21 C.F.R. § 312.21(a)
(FDCA), as amended from time to time, and the foreign equivalent thereof. 
 1.56 Phase II Study  

The term “Phase II Study” shall mean a human clinical trial, for which the primary endpoints include a determination of dose ranges and/or a
preliminary determination of efficacy in patients being studied as described in 21 C.F.R. § 312.21(b) (FDCA), as amended from time to time, and the foreign equivalent thereof. 

1.57 Phase III Study  
 The term
“Phase III Study” shall mean a human clinical trial that is prospectively designed to demonstrate statistically whether a product is safe and effective for use in humans in a manner sufficient to obtain Regulatory Approval to market such
product in patients having the disease or condition being studied as described in 21 C.F.R. § 312.21(c) (FDCA), as amended from time to time, and the foreign equivalent thereof. 

1.58 Pivotal Study  
 The term
“Pivotal Study” shall mean a human clinical trial that is prospectively designed to demonstrate statistically whether a product is safe and effective for use in humans in a manner sufficient to obtain Regulatory Approval to market such
product having the disease or condition being studied. Pivotal Studies include, but are not limited to Phase III Studies. 
 1.59 Private
Financing  
 The term “Private Financing” shall mean, with respect to PEGA1, the issuance and sale of its capital stock, or debt instruments
that are convertible into its capital stock, to one or more investors in a bona fide transaction for purposes of raising capital to fund development of its programs and/or for other general corporate purposes (e.g. such as the contemplated
PEGA1’s Series A financing pursuant to the term sheet entered into between, amongst others, PEGA1, BioDiscovery 5 FPCI, and Medicxi Growth I LP (the “Series A Agreement”)). 

  
 11 

 1.60 Proceeds  

The term “Proceeds” shall mean the aggregate proceeds from any Strategic Transaction being conveyed in such Strategic Transaction to PEGA1 or its
Affiliates or their stockholders, including any option fees, upfront payments, event based milestone payments, royalty payments and all other monetary and non-monetary consideration (with non-monetary consideration being valued at the fair market value thereof) paid or made to PEGA1 or its Affiliates or stockholders, directly or indirectly from any party to a Strategic Transaction. 

1.61 Product  
 The term
“Product” shall mean any product, containing the Compound as pharmaceutically active agent, regardless of their finished forms or formulations or dosages. 

1.62 Regulatory Approval  
 The term
“Regulatory Approval” shall mean any approvals, licenses, registrations or authorizations by Regulatory Authority, necessary for the sale of a Product in the Field in a regulatory jurisdiction in the Territory. 

1.63 Regulatory Authority  
 The term
“Regulatory Authority” shall mean any national, supranational (e.g., the European Commission, the Council of the European Union, the European Medicines Agency), regional, state or local regulatory agency, department, bureau, commission,
council or other governmental entity including the FDA, in each country involved in the granting of Regulatory Approval for the Product. 

1.64 Regulatory Documentation  
 The term
“Regulatory Documentation” shall mean all (i) applications (including IND and Drug Approval applications), Regulatory Approvals, regulatory materials, drug dossiers, master files (including Drug Master files); (ii) correspondence,
records and reports submitted to or received from Regulatory Authorities and all supporting documents including all adverse event files and complaint files; and (iii) clinical and other data contained or relied upon in any of the foregoing; and
(iv) any information that relates to the pharmacology, toxicology, chemistry, manufacturing and controls data, methods, processes and reports, executed batch records, safety and efficacy, and any safety database required to be maintained for
Regulatory Authorities relating to the Compound provided that such Regulatory Documentation exists and is reasonably retrievable by Roche. 

1.65 Regulatory Exclusivity  
 The term
“Regulatory Exclusivity” means any exclusive marketing rights or data exclusivity rights conferred by any governmental authority under applicable law with respect to a Product in a country or jurisdiction in the Territory to prevent Third
Parties from selling such Product in such country or jurisdiction, other than a Patent Right, including orphan drug exclusivity, pediatric exclusivity, rights conferred in the U.S. under the FD&C Act, in the EU under Directive 2001/83/EC, or
rights similar thereto in other countries or regulatory jurisdictions in the Territory. 

  
 12 

 1.66 Roche Glycoengineering Technology Patent Rights  

The term “Roche Glycoengineering Technology Patent Rights” shall mean the Patent Rights as listed in Appendix 1.65. 

1.67 Roche Know-How  

The term “Roche Know-How” shall mean the Know-How Controlled by Roche
as of the Effective Date as listed in Appendix 1.66(a) of this Agreement. For purposes of clarity, the Roche Know- How as identified in Appendix 1.66(b) is specifically excluded from the Roche Know-How. 

1.68 Roche Patent Rights  
 The term
“Roche Patent Rights” shall mean the Patent Rights relating to the Compound or any Product Roche Controls as of the Effective Date as listed in Appendix 1.67. 

1.69 Royalty Term  
 The term
“Royalty Term” shall mean, with respect to a Product and for a given country, the period of time commencing on the date of First Commercial Sale of such Product in such country and ending on the later of the date that is (a) ten (10)
years after the date of the First Commercial Sale of such Product in such country, or (b) the expiration of the last to expire Valid Claim within the Roche Patent Rights, Roche Glycoengineering Technology Patent Rights, and/or a Joint Patent
Right in such country Covering the use, manufacture, import, offering for sale, or sale of the Product or (c) expiration of the last to expire Regulatory Exclusivity conferred by the applicable Regulatory Authority in such country for such
Product. 
 1.70 Sublicensees  
 The
term “Sublicensees” shall mean a person or entity to which PEGA1 has actually or potentially licensed rights pursuant to this Agreement. 

1.71 Strategic Transaction  
 The term
“Strategic Transaction” shall mean, with respect to PEGA1 (i) a Change of Control, or (ii) the execution of a Partner Agreement. For clarity either of the foregoing occurring (a) after the IPO Effective Time or (b) [####] or more
after First Commercial Sale of a Product in [####] Country shall not be deemed a Strategic Transaction. 
 1.72 Successful Manufacture
 
 The term “Successful Manufacture” shall mean the successful release of a Clinical Batch. 

1.73 Territory  
 The term
‘Territory” shall mean all countries of the world. 

  
 13 

 1.74 Third Party  

The term ‘Third Party” shall mean a person or entity other than (i) PEGA1 or any of its Affiliates or (ii) Roche or any of its Affiliates.

 1.75 US  
 The term “US”
shall mean the United States of America and its territories and possessions. 
 1.76 US$ 

The term “US$” shall mean US dollars. 

1.77 Valid Claim  
 The term “Valid
Claim” shall mean a claim contained in any (i) unexpired, in force and issued Roche Patent Right or Joint Patent Right that has not been disclaimed, revoked or held invalid by a final non-appealable
decision of a court of competent jurisdiction or government agency or (ii) pending Roche Patent application or Joint Patent application in any country of the Territory that (a) is on file with the applicable patent office and has shown
evidence of reasonably consistent activity to advance to issuance of a patent and (b) which application has been on file with the applicable patent office for no more than [####] from the earliest date to which the patent application claims
priority. 
 1.78 Additional Definitions  

Each of the following definitions is set forth in the Section of this Agreement indicated below 

 

					
	 Definition
	  	Section	 
		
	 Accounting Period
	  	 	11.1	 
		
	 Alliance Manager
	  	 	4.1	 
		
	 Bankruptcy Code
	  	 	21	 
		
	 Breaching Party
	  	 	20.3	 
		
	 PEGA 1 Indemnitees
	  	 	16.1	 
		
	 PEGA 1 Invention
	  	 	1.41	 
		
	 CMC
	  	 	1.21	 
		
	 Decision Period
	  	 	14.7	 
		
	 Disclosing Party
	  	 	1.17	 

  
 14 

					
	 Escalation Notice
	  	 	22.2	 
		
	 Expert Committee
	  	 	10.6	 
		
	 Governing Law
	  	 	22.1	 
		
	 Indemnified Losses
	  	 	16.1	 
		
	 Indemnifying Party
	  	 	16.3	 
		
	 Initiating Party
	  	 	14.7	 
		
	 INN
	  	 	14.3	 
		
	 Joint Invention
	  	 	1.41	 
		
	 Negotiation Period
	  	 	3	 
		
	 Non-Breaching Party
	  	 	20.3	 
		
	 Patent Term Extensions
	  	 	14.11	 
		
	 Payment Currency
	  	 	11.3	 
		
	 · Peremptory Notice Period
	  	 	20.3	 
		
	 Publishing Notice
	  	 	18.4	 
		
	 Publishing Party
	  	 	18.4	 
		
	 Receiving Party
	  	 	1.17	 
		
	 Relative Commercial Value
	  	 	10.5	 
		
	 Review Period
	  	 	3	 
		
	 Roche Indemnitees
	  	 	16.2	 
		
	 Roche Invention
	  	 	1.41	 
		
	 Series A Agreement
	  	 	1.57	 
		
	 Settlement
	  	 	14.7	 
		
	 SPCs
	  	 	14.11	 
		
	 Suit Notice
	  	 	14.7	 

  
 15 

					
	 Transition Period
	  	 	20.12	 
		
	 Transfer
	  			
		
	 USAN
	  	 	14.3	 
		
	 Valuation Firm
	  	 	10.7.3	 

 Where this Agreement in parenthesis refers to a legal expression in German it is the relevant Swiss nomenclature. In case of a
dispute solely such Swiss nomenclature shall be relevant and shall prevail over the English expression. 
  

	2.	 Grant of License 

2.1 Exclusive License  
 Roche hereby
grants to PEGA1 an exclusive (subject to Section 2.6 below even as to Roche), sublicensable (subject to Sections 2.3, 2.4 and 2.5 and Article 3) worldwide right and license under Roche Patent Rights, Roche Glycoengineering Technology Patent
Rights, Roche Know-How, and Roche’s interest in Joint Patent Rights and Joint Know-How, to research, have researched, develop, have developed, register, have
registered, use, have used, make, have made, import, have imported, export, have exported, market, have marketed, distribute, have distributed, offer for sale, have offered for sale, sell and have sold Compound and Products in the Field in the
Territory. 
 2.2 Lonza Sublicense  

Roche hereby grants to PEGA1 an exclusive (even as to Roche) sub-license of the rights licensed to Roche under the
Lonza Agreement solely to develop, have developed, commercialize, have commercialized, make, have made, use, have used, sell, have sold, offer for sale, have offered for sale, import and have imported Compound and/or Product in the Field in the
Territory. The sublicense granted under this Section 2.2 shall be subject to the rights and obligations and undertakings of Roche, as applicable and consistent with the Lonza Agreement. Roche shall act as the sole direct contact with Lonza
Sales AG in relation to the sub-license under this Section 2.2. PEGA1 shall comply with the terms of the Lonza Agreement to the extent such terms are disclosed in the respective Appendix attached hereto.

 Roche shall not amend the Lonza Agreement in a manner that affects any such sub-licenses hereunder, shall use
commercially reasonable efforts to enforce and maintain such agreements with respect to the Compound and/or the Product, and shall promptly notify PEGA1 in writing of any threatened or actual termination or notice regarding same with respect to such
Lonza Agreement with respect to the Compound and/or the Product. Roche shall provide copies (with reasonable redactions) of any amendments to such Lonza Agreement to PEGA1 once executed. If the Lonza Agreement terminates or may terminate, Roche
shall use commercially reasonable efforts to maintain the applicable sub-license to PEGA1; if Roche is not able to maintain the applicable sub-license, PEGA1 shall have
the right to attempt to cure any breach giving rise to such actual or threatened termination and may credit any amounts paid by PEGA1 to maintain any such sub-license against any amounts owed to Roche
hereunder, provided that such amounts credited against any amounts owned to Roche hereunder shall not exceed the amount owed by Roche for the respective license. 

  
 16 

 2.3 Right to Sublicense to Affiliates  

PEGA1 shall have the right to grant written sublicenses to its Affiliates under its rights granted under Section 2.1. If PEGA1 grants such a sublicense,
PEGA1 shall notify Roche of such sublicense to its Affiliates and shall ensure that all of the applicable terms and conditions of this Agreement shall apply to all such Affiliates to the same extent as they apply to PEGA1 for all purposes. PEGA1
assumes full responsibility for the performance of all obligations and observance of all terms so imposed on such Affiliates and shall itself account to Roche for all payments due under this Agreement by reason of such sublicense. 

2.4 Right to enter into Partner Agreements  

Subject to Roche’s rights under Article 3, PEGA1 shall have the right to enter into a Partner Agreement with one or more Partners under its rights granted
under Section 2.1, in each case with Roche’s prior written consent (such consent not to be unreasonably withheld or delayed,). 
 If PEGA1 grants
such rights to the Partner(s), PEGA1 shall ensure that all of the applicable terms and conditions of this Agreement shall apply to the Partner(s) to the same extent as they apply to PEGA1 for all purposes. PEGA1 assumes full responsibility for the
performance of all obligations and observance of all terms so imposed on such Partner(s) and shall itself account to Roche for all payments due under this Agreement by reason of such rights granted to Partner(s). The Partners of PEGA1 shall have no
right to further sub-license rights to develop and commercialize the Compound or Product to a Third Party without Roche’s express prior written consent (such consent not to be unreasonably withheld or
delayed). 
 Subject to Section 10.7.1, Roche (acting reasonably) shall have the right to withhold its consent only if a potential Partner
(i) does not have substantially similar compliance standards as PEGA1 and/or (ii) does not have, and is not reasonably likely to obtain, the financial means or the capabilities to perform the obligations under this Agreement to the same
extent as PEGA1. Prior to entering into a Partner Agreement, PEGA1 shall provide Roche with a draft term sheet, draft Partner Agreement or any such draft amendment with reasonable redactions allowing such assessment, and following execution, with
the fully unredacted copy of such Partner Agreement. Roche shall confirm or withhold its consent in writing within [####] following receipt of a draft term sheet, Partner Agreement or any such amendment. If, after good faith negotiations not to
exceed [####], the Parties cannot settle any dispute as to whether Roche has unreasonably withheld its approval of the Partner and/or the terms of the Partner Agreement or amendment, the dispute shall be initially referred to the executive officers
of the Parties in accordance with Section 22.2. Should the Parties fail to agree within [####] of such referral, then the dispute shall be determined as set forth in Section 22.1. 

Any Partner Agreement shall include the right to disclose a copy of the Partner Agreement and the Partner’s confidential information to Roche as
necessary for Roche to ensure compliance with the terms of this Agreement. 

  
 17 

 2.5 Sub-Contractors  

PEGA1 has the right to sub-contract the work performed under this Agreement. Any
sub-contract agreement shall include the right to disclose (i) a copy of the agreement and confidential information to Roche and (ii) the right to assign the agreement to Roche, including the right
to transfer of the ownership of data, information and results arising therefrom to Roche to the same extent as to PEGA1. 
 2.6 Retained
Rights  
 Notwithstanding anything in this Agreement, Roche shall retain the right to use the Compounds for internal research purposes (e.g. as a
reference model), so long as Roche notifies PEGA1 prior to undertaking in vivo experiments for such internal research purposes with the Compound. If any research under this Section 2.6 is conducted by Roche, any
Know-How or Patent Rights related to Compound resulting from such research by Roche shall become part of the Roche Know-How and Roche Patent Rights and shall be added to
the Appendices 1.66(a) or 1.67, as applicable. 
 3. Right of First Negotiation 

3.1 Due Diligence  
 If PEGA1, at any time
during the Agreement Term intends to enter into a Strategic Transaction with respect to Product, PEGA1 shall promptly inform Roche in writing of such plan (“PEGA1 Notice”). 

In the event that PEGA1 has given Roche a notification pursuant to the first paragraph of this Section 3.1, PEGA1 shall without delay prepare the Data
Room and upon such Data Room being available, PEGA1 shall promptly inform Roche in writing thereof and give Roche access to the Data Room and provide Roche with an executive summary report on the development, manufacture and commercialization of the
Compound or Product (“Review Notice”). 
 During a [####] period following Roche’s reception of the access to the Data Room
(“Review Period”), Roche shall have the right to review the Data Room and to perform due diligence. During the Review Period employees of Roche or representatives of Roche (who have a need to access the Confidential Information and
who are bound by obligations of confidentiality and use with respect to such Confidential Information that are at least as restrictive as those in this Agreement) shall have at reasonable times the opportunity to ask questions of and receive answers
from representatives of PEGA1 related to the Product and the program. PEGA1 shall respond to Roche’s reasonable inquiries in a timely fashion and without delay and shall not withhold any material information from Roche in response to
Roche’s inquiries or otherwise in connection with the Product and the program. All information provided to Roche pursuant to this Section 3.1 shall constitute Confidential Information of PEGA1. 

3.2 Grant of Rights  
 PEGA1 hereby grants
to Roche, upon receipt of the ROFN Exercise Notice pursuant to Section 3.3, the exclusive right to negotiate in good faith the terms and conditions of a proposed transaction (e.g. with respect to an exclusive license or an acquisition)
(“Proposed Transaction”) in accordance with the terms of this Article 3 (the “Right of First Negotiation”). For clarity the Right of First Negotiation shall cease to apply after (i) the IPO Effective Time or
(ii) a Change of Control of PEGA1. 

  
 18 

 If the Strategic Transaction which PEGA1 intends to enter into is a Partner Agreement, such Right of First
Negotiation is only applicable in case such Partner Agreement concerns either [####] If such Partner Agreement concerns scenario (a), Roche is entitled to exercise its Right of First Negotiation on the Territory as a whole. If such Partner Agreement
concerns scenario (b), Roche is entitled to exercise its Right of First Negotiation on the concerned Major Markets, but may request to exercise its Right of First Negotiation on the Territory as a whole and such request shall not be unreasonably
declined by PEGA1. If such Partner Agreement concerns scenario (c), Roche is entitled to exercise its Right of First Negotiation on Europe as a whole, but may request to exercise its Right of First Negotiation on the Territory as a whole and such
request shall not be unreasonably declined by PEGA1. 
 If the Strategic Transaction is a Change of Control Roche is entitled to exercise its Right of First
Negotiation to obtain the rights as contemplated in such Change of Control. 
 3.3 Process  

Roche shall have the right to exercise the Right of First Negotiation at any time during the Review Period by written notice to PEGA1 (the “ROFN
Exercise Notice”). 
 Together with the ROFN Exercise Notice, Roche shall provide PEGA1 a written offer for the terms and conditions of the
Proposed Transaction in form of a draft term sheet, and the Parties thereafter shall have [####] to exclusively and in good faith negotiate the terms and conditions of the Proposed Transaction in form of a final term sheet (the ‘Term
Sheet”). 
 Upon finalization of the Term Sheet, the Parties shall have a further period of up to [####] to exclusively and in good faith negotiate
and finalize the respective agreements (the “Reverse Agreement”). 
 The term “Negotiation Period” shall mean the period
of time commencing on the date of Roche’s ROFN Exercise Notice and ending either (i) [####] after such exercise in case the Parties fail to execute a mutually agreed upon Term Sheet or (ii) [####] after such exercise in case the Parties could
initially agree on the Term Sheet but fail to reach the Reverse Agreement. 
 If (i) Roche rejects its interest to access the Data Room,
(ii) Roche during the Review Period or the Negotiation Period confirms in writing to PEGA1 that it is not interested in the Proposed Transaction or (iii) the Parties, after good faith discussions during the Negotiation Period, cannot agree
on the Term Sheet or the Reverse Agreement, then PEGA 1 shall be free to enter into a Strategic Transaction with a Third Party in the Field in the Territory. Notwithstanding the foregoing, if the Parties have failed to agree on a Term Sheet or on a
Reverse Agreement, during the first [####] after termination of the negotiations between the Parties, PEGA1 shall not enter into a Strategic Transaction on terms and conditions more favorable for any reason whatsoever to the Partner or the Change of
Control Group (as applicable) than those offered to Roche. 

  
 19 

 If (i) Roche rejects its interest to access the Data Room or (ii) Roche during the Review Period
or the Negotiation Period confirms in writing to PEGA1 that it is not interested in the Proposed Transaction and (iii) thereafter PEGA 1 does not enter into a Strategic Transaction, but continues the development and commercialization of the
Compound and Products, this entire Article 3 shall apply mutatis mutandis at any time during the Agreement Term, if PEGA1 again intends to enter into a Strategic Transaction with respect to Product and there is additional material clinical data
available as compared to the clinical data previously reviewed by Roche in the Data Room. 
 If (i) Roche rejects its interest to access the Data Room
or (ii) Roche during the Review Period or the Negotiation Period confirms in writing to PEGA1 that it is not interested in the Proposed Transaction and (iii) thereafter PEGA 1 enters into a Partner Agreement which includes the rights
relating to Products in some countries of the Territory and excludes the rights relating to Products in some other countries of the Territory (the “Remaining Territory’’), this entire Article 3 shall apply mutatis mutandis at
any time during the Agreement Term, if PEGA1 intends to enter into a Partner Agreement with respect to Product in the Remaining Territory. 

3.4 Consequences of termination of this Agreement  

The Parties shall terminate this Agreement by mutual consent if they enter into a Reverse Agreement and the Parties shall agree therein which of the
consequences of termination as set forth in Section 19.8 shall be applicable. 
 4. Alliance Managers and Technology Transfer 

4.1 Alliance Managers  
 Each Party shall
designate an “Alliance Manager’’ within after the Effective Date. The Alliance Managers shall facilitate the Roche Know-How transfer and communication between the Parties and are the
primary points of contact between the Parties with respect to all matters arising under this Agreement, including inter alia informational requests from PEGA 1 to Roche during the Agreement Term. Each Party may change its Alliance Manager from time
to time in its sole discretion. 
 4.2 Roche Know-How Transfer  

Promptly, but not later than [####] after the Effective Date, Roche shall transfer to PEGA1 the Roche Know-How listed
in Appendix 1.65, at no cost to PEGA1. Such Roche Know-How transfer shall occur electronically after the Effective Date by granting PEGA1 download rights to the electronic database for a period of at least
[####] from the Effective Date and up to a maximum of [####] from the Effective Date subject to the requirements as set forth in this Section 4.2 below. 

If PEGA1 identifies a need for additional Know-How of Roche relating to the Compound within [####] from the Effective
Date (the ‘Transfer Period”), Roche shall provide written or verbal answers to reasonable questions relating to the Compound provided that the additionally requested Know-How (I) does not
include any general Roche technology containing intellectual property Roche would otherwise license with financial terms, (ii) still exists and (iii) is reasonably retrievable by Roche. Roche provides further support to PEGA1 upon
PEGA1’s written request during a period of [####] from the expiry of the Transfer Period and Roche will provide such support to PEGA1 at no cost to PEGA1, provided that the additionally requested Know-How
(i) does not include any general Roche technology containing intellectual property Roche would otherwise license with financial terms, (ii) still exists and (iii) is reasonably retrievable by Roche. 

  
 20 

 4.3 Transfer of CMC materials  

Roche will transfer the CMC materials as listed in Appendix 4.3 free of charge. Roche shall have no obligation to perform any additional activities (e.g.
retesting, analyses) concerning such materials. Upon transfer the CMC materials shall be owned by PEGA1. 
 Roche will deliver CMC materials to such address
as PEGA1 shall notify to Roche in writing. 
 4.4 Further Obligations  

Pursuant to Section 4.2, Roche shall provide information, documentation, and reasonable technical support related to the manufacturing process to enable a
qualified contract manufacturer to establish the manufacturing process at approximately the same scale as was practiced at Roche. 
 5. Diligence

 PEGA1 shall use Commercially Reasonable Efforts to develop and commercialize the Compound and Products in the Field in the Territory. 

6. Development 
 6.1 Responsibility
 
 PEGA1 shall be solely and exclusively responsible at its own expense for the non-clinical and clinical
development of the Product in the Field in the Territory. 
 6.2 Development Plan  

PEGA1 will conduct the development of the Compound and Products in the Field in the Territory in accordance with a written plan (“Development
Plan”). PEGA1 shall annually send to Roche a then current version of the Development Plan by the end of December. An initial Development Plan is set forth in Appendix 6.2. 

If PEGA1 wishes to change the manufacturing process of the Compound or the Product resulting in a change of the cell bank expressing the Compound, then PEGA1
shall provide written notice to Roche of the nature of such intended work. For clarity: any change of the cell bank resulting in the expression of any compound that is not Compound, including but not limited to modifications of Compound, shall
require Roche’s prior written approval of such work, such consent not to be unreasonably withheld or delayed. 
 6.3 Reporting 

 During the Agreement Term and up to the First Commercial Sale of the Products, PEGA1 shall have the obligation to submit annual reports to Roche
describing in sufficient and reasonable detail the development progress of the Products by PEGA1, its Affiliates and Sublicensees, including the Development Plan pursuant to Section 6.2. PEGA1 shall send such annual report at the end of
December of each year. 

  
 21 

 6.4 Right of Reference  

Roche hereby grants to PEGA1 the right, sublicensable, to rely upon and a right to copy, access, and otherwise use, all information and data relating to
Compound or Product on file at the Regulatory Authority (including all CMC information and Regulatory Documentation) to obtain Regulatory Approval of the Product and Roche shall, if requested by PEGA1, provide a signed statement that PEGA1 may rely
on, and the Regulatory Authority may access in support of PEGA1 ‘s application for such Regulatory Approval, any underlying raw data or information on file at the Regulatory Authority and submitted by Roche to such Regulatory Authority with
respect to any Regulatory Approval or Regulatory Documentation controlled by Roche that relates to the Compound. 
 7. Supply 

7.1 Clinical and Non-Clinical Supply of Product  

PEGA1 shall be solely and exclusively responsible at its own expense for the manufacture and supply of clinical supplies of the Product. PEGA1 shall supply at
its own cost all clinical and non-clinical supply of Product during the Term, either by itself, or through a Third Party. 

7.2 Commercial Supply of Product  
 PEGA1
shall be solely and exclusively responsible at its own expense for the commercial manufacture and commercial supply of Product for sale in the Territory. PEGA1 shall have the right to sub-contract the
commercial supply to Third Parties subject to Roche’s prior written consent (such consent not to be unreasonably withheld or delayed, and if no written response for consent from Roche is received by PEGA1 within [####], such consent shall be
deemed given). 
 8. Regulatory 
 8.1
Responsibility  
 PEGA1 shall be solely and exclusively responsible at its own expense for all regulatory affairs related to Compound and Products in
the Field in the Territory including the preparation, filing and maintaining of applications for Regulatory Approval, as well as any or all governmental approvals required to develop, have developed, make, have made, use, have used, import, have
imported sell and have sold Compound and Products. PEGA1 shall be solely and exclusively responsible 
 25 for pursuing, compiling and submitting all
regulatory filing documentation, and for interacting with regulatory agencies, for Compound and Products in all countries in the Territory. PEGA1 shall own and file in its own discretion all regulatory filings and Regulatory Approvals for the
Compound and Product in all countries of the Territory. PEGA1 shall supply Roche with a copy of all material communications (including meetings) with Regulatory Authorities and Regulatory 

  
 22 

 
Authority questions or concerns regarding significant issues regarding quality, significant safety findings, significant clinical or nonclinical findings affecting patient safety or significant
efficacy or lack of efficacy, all related to Compound or Products, within [####]from receipt of such material communications by PEGA1 to the extent PEGA1 is aware of and have the right to disclose such material communications. 

8.2 Informed Consent Forms  
 Any Informed
Consent forms with study subjects under any PEGA1 study or any of its Partner study containing the Product shall include the right to transfer samples, data and information from such study to Roche. 

8.3 Pharmacovigilance Agreement  

Promptly after the Effective Date, PEGA1 and Roche shall negotiate in good faith and enter into a Pharmacovigilance Agreement in accordance with all Applicable
Laws which sets forth, among other things, the responsibilities and obligations of the Parties with respect to the procedures and timeframes for compliance with all Applicable Laws (and each of the Party’s policies) pertaining to safety
reporting and their related activities, with respect to activities related to the Products under this Agreement. The transfer of historical Safety Data together with the responsibility for Pharmacovigilance activities will be part of the
Pharmacovigilance Agreement. For clarity, the Pharmacovigilance Agreement shall prevail this Agreement with regard to the subject matter of such Pharmacovigilance Agreement. 

9. Commercialization 
 9.1
Responsibility  
 PEGA1 shall be solely and exclusively responsible at its own expense, for the marketing, promotion, sale and distribution of
Products in the Territory. 
 9.2 Reporting and Updates  

After the First Commercial Sale of the Product and until the expiry of the Agreement Term, PEGA1 shall inform Roche in a reasonably detailed annual report
regarding the commercialization of Products in the Field in the Territory by PEGA1, its Affiliates and Sublicensees. The first such annual report shall be provided on the first anniversary of the First Commercial Sale. Each subsequent annual report
shall be provided on subsequent anniversaries of the First Commercial Sale. Each annual report shall include non-binding forecasted sales, annually for the next [####]. 

In addition to the foregoing, upon request of Roche, PEGA1 shall update Roche regarding the commercialization of the Product in the Territory in the Field by
PEGA1, its Affiliates and Sublicensees. Upon such request of Roche, PEGA1 shall provide an update, in writing and/or through a meeting (face to face/ tele-presence/videoconference or telephone). Roche shall not request an update more frequently than
[####] per Calendar Year. 

  
 23 

 10. Payment 

10.1 Upfront Payment  
 Within thirty
(30) days after the Effective Date, PEGA1 shall pay to Roche [####]. This payment shall be non-refundable. 

10.2 Development Event Payments  
 PEGA1
shall pay to Roche up to a total of [####] in relation to the achievements of development events with respect to a Product achieving such events. The development event payments under this Section 10.2 shall be paid by PEGA1 according to the
following schedule of development events and shall be non-refundable. 
  

			
	 Development Event
	  	 Payment

	[####]	  	[####]
	[####]	  	[####]
	[####]	  	[####]
	[####]	  	[####]
	[####]	  	[####]
	[####]	  	[####]

 Each development event payment shall be paid only once the first time the first Product reaches the applicable triggering
event, regardless of the number of times such events are reached by the same or another Product. 
 If for a Product, a development event does not occur or
is not required, then PEGA1 shall pay such development event payment with the next development event payment triggered by such Product. 
 [####] 

Upon reaching development events, PEGA1 shall timely notify Roche and development event payments shall be paid by PEGA1 to Roche within [####] from occurrence
of the applicable event. 
 10.3 Sales Based Events  

PEGA1 shall pay to Roche up to a total of US Dollars [####] based on aggregate Calendar Year Net Sales of a Product in the Territory: 

  
 24 

			
	 Net Sales Threshold
	  	 Payment

	Total Calendar Year Net Sales in the Territory of a Product [####]	  	[####]
	Total Calendar Year Net Sales in the Territory of a Product [####]	  	[####]
	Total Calendar Year Net Sales in the Territory of a Product [####]	  	[####]
	Total Calendar Year Net Sales in the Territory of a Product [####]	  	[####]
	Total Calendar Year Net Sales in the Territory of a Product [####]	  	[####]
	TOTAL	  	[####]

 Each of the sales based event payments shall be paid no more than once during the Agreement Term, at first occurrence of the
event for the Product in the Territory first reaching the respective Net Sales threshold, irrespective of whether or not the previous sales based event payment was triggered by the same or by a different Product and irrespective of whether the
previous threshold was achieved in the same or different Calendar Year, and shall be non-refundable and non-creditable. PEGA1 shall notify Roche of each sales based
event timely (but in no event longer than [####]after the respective sales based event occurred). Sales based events payments shall be paid by PEGA1 to Roche along with the royalties due on Net Sales within [####] after the end of the Accounting
Period in which the sales based event occurred. 
 10.4 Royalty Payments  

10.4.1 Royalty Term 
 Royalties shall be payable by PEGA1
on Net Sales of Products on a Product-by-Product and country-by-country basis until the
expiry of the Royalty Term. Thereafter, the licenses with respect to such Product and country shall be fully paid up and non-exclusive. 

10.4.2 Royalty Rates 
 The following royalty rates shall
apply to the respective tiers of aggregate Calendar Year Net Sales of a Product, on an incremental basis, as follows: 
  

			
	 Tier of global Calendar Year Net Sales
	  	 Percent (%) of [####]

	[####]	  	[####]
	[####]	  	[####]
	[####]	  	[####]

  
 25 

 For example, if Net Sales of a Product in the Territory, for a given Calendar Year, are [####], then
royalties owed to Roche on such Net Sales of such Product for that Calendar Year shall equal [####] calculated as follows: 
 [####] royalty payment 

10.4a—Reductions 
 In the event that:

 (i) in any Calendar Quarter at any time during the Royalty Term and after entry of a Generic Product there has been a decline of the Net Sales of the
applicable Product in such country greater than [####] of the level of the Net Sales of such Product achieved in any of the [####]immediately prior to such entry, then royalties get reduced by [####]. 

(ii) PEGA1 is required, or in the exercise of reasonable judgement and with the advice of a patent counsel deems it necessary in order to avoid infringement of
the rights of a Third Party, to enter into an agreement with a Third Party in order to obtain a license to a Third Party Patent Right in order to research, have researched, develop, have developed, register, have registered, use, have used, make,
have made, import, have imported, export, have exported, market, have marketed, distribute, have distributed, sell, have sold and otherwise exploit the Compound and Products in the Field in the Territory, PEGA1 shall be entitled to deduct from
royalties payable to Roche under this Section 10.4 in a given Calendar Year with respect to such Product in such country [####] of royalties paid to such Third Party in such Calendar Year and under such agreement to the extent directly
attributable to such Third Party Patent Right. 
 (iii) If a court or governmental agency of competent jurisdiction requires PEGA1 or any of its Affiliates
or its or their Sublicensees to grant a compulsory license to a Third Party permitting such Third Party to make and sell a Product in a country within the Territory as a condition of PEGA1 or any of its Affiliates being permitted to commercialize
such Product in that country, then the royalties due to Roche shall be reduced by a percentage as necessary to match to rate that the compulsory licensee pays to PEGA1 in that country. 

In no events shall the amounts payable to Roche under 10.4.2 be reduced by more than [####] of what would otherwise be due by operation of section 10.4.2
before application of section 10.4a. 
 10.5 Combination Product  

If PEGA1 or its Affiliates or Sublicensees intend to sell a Combination Product, then the Parties shall apply the process such as described under the Net Sales
definition to determine an appropriate adjustment to Net Sales to reflect the relative commercial value contributed by the components of the Combination Product (the “Relative Commercial Value”). If such process requires good faith
negotiations and where, after such good faith negotiations not to exceed [####], the Parties cannot agree to an appropriate adjustment, the dispute shall be initially referred to the executive officers of the Parties in accordance with
Section 22.2. Should the Parties fail to agree within [####]of such referral, then the Relative Commercial Value shall be determined by an Expert Committee under the procedures of Section 10.6. 

  
 26 

 10.6 Expert Committee  

If the Parties are unable to agree on the Relative Commercial Value under Section 10.5, then Roche will select one (1) individual who would qualify
as an Expert, PEGA1 will select (1) individual who would qualify as an Expert, and those two (2) individuals shall select one (1) individual who would qualify as an Expert and who shall be chairman of a committee of the three Experts
(the “Expert Committee”), each with a single deciding vote. The Expert Committee will promptly hold a meeting to review the issue under review, at which it will consider memoranda submitted by each Party at least [####] before the
meeting, as well as reasonable presentations that each Party may present at the meeting. The determination of the Expert Committee as to the issue under review will be binding on both Parties. The Parties will share equally the costs of the Expert
Committee. Unless otherwise agreed to by the Parties, the Expert Committee may not decide on issues outside the scope mandated under terms of this Agreement. 

10.7 Strategic Transaction  
 10.7.1
Payments under Proceeds 
 If, prior to the IPO Effective Time or [####] after the First Commercial Sale of a Product in the US or a Major EU5 Country
whichever occurs earlier, PEGA1 executes one or more Strategic Transactions, PEGA1 shall, on an incremental basis, pay to Roche the following amounts of any Proceeds: 
  

	 	a)	 [####] of Proceeds if, at the time of the Strategic Transaction, the aggregate capital raised by PEGA1 in one
or more Private Financings is equal to or less than the [####] stipulated in PEGA1’s Series A Agreement, and 

  

	 	b)	 [####] of Proceeds if, at the time of the Strategic Transaction, the aggregate capital raised by PEGA1 in one
or more Private Financings is more than [####]; 

 ((a) and (b) together “Strategic Transaction Revenues”). For
clarity, Strategic Transaction Revenues received after (i) the IPO Effective Time, or (ii) [####]after the First Commercial Sale in [####]shall be owed to Roche even if a portion or all of the proceeds associated with such Strategic Transaction
are conveyed to PEGA1 or its Affiliates after either of the foregoing. 
 For the avoidance of doubt, should PEGA1 enter into multiple Strategic
Transactions, then the Proceeds of all such Strategic Transactions shall be considered on an aggregate basis for the purpose of calculating Strategic Transaction Revenues pursuant to this Section 10.7.1. Any payment to Roche under this
Section 10.7.1 shall be made before any payments are made to any shareholders and any other person under the shareholder agreement. 
 A Strategic
Transaction shall not be structured with the intent to avoid payments to Roche otherwise due to Roche under this Section 10.7.1. As such PEGA1 shall endeavor to avoid structuring Strategic Transactions in the following ways without first having
consulted with Roche and having obtained Roche’s prior written consent (such consent not to be unreasonably withheld or delayed, and if no written response for consent from Roche is received by PEGA1 within [####], such consent shall be deemed
given): 

  
 27 

 (i) PEGA1 accepting any direct or indirect investment of a Partner or a Partner’s
Affiliates’ in PEGA1’s or its Affiliates’ equity securities during the Agreement Term. PEGA1 or its Affiliates investing in a Partner’s or Partner’s Affiliates’ equity securities during the Agreement Term; and 

(ii) PEGA1 or its Affiliates accepting any non-monetary consideration from a Partner or a
Partner’s Affiliates under a Partner Agreement or (b) granting rights to a Partner or a Partner’s Affiliates under a Partner Agreement with respect to any products or services other than the Compound or Product and services relating
thereto. 
 Considerations that Roche receives pursuant to this Section 10.7.1 are in addition to all payments made by PEGA1 pursuant to Sections 10.1,
10.2, 10.3 and 10.4 above with no right to offset. 
 10.7.2 Timing 

PEGA1 shall calculate the Strategic Transaction Revenues owed under Section 10.7.1 for each Calendar Quarter and shall make such payments within
[####]after the end of each Calendar Quarter in which such Proceeds occur according to the terms and conditions of the Strategic Transaction. 
 10.7.3
Value of Proceeds 
 If at the time of the completion of a Strategic Transaction PEGA1 owns or controls (whether through a license or otherwise) other
assets or rights in addition to the Compound or Product rights that are subject of the Strategic Transaction, then the Parties shall negotiate and agree in good faith the value of the Proceeds, exclusive of the value attributed to the PEGA1’s
other assets. If after good faith negotiations, the Parties cannot agree on an allocation of value among the PEGA1’s assets within [####]after the completion of a Strategic Transaction, then the dispute shall be initially referred to the
executive officers of the Parties in accordance with Section 21.2. Should the Parties fail to agree within [####]of such referral, then Roche shall select a nationally recognized investment banking, accounting or valuation firm (independent of
either party) having expertise in the pharmaceutical industry and reasonably acceptable to PEGA1 (“Valuation Firm”) to perform an independent valuation of the relevant assets of PEGA1, which determination shall be final and binding
on the Parties. The Valuation Firm shall be requested to determine the allocation of the value between the PEGA1 ‘s assets within [####] of its appointment and to notify the Parties in writing of its determination. The fees and expenses of such
Valuation Firm shall be paid by Roche, however, if such determination of the value of the Proceeds by the Valuation Firm is more than PEGA1’s last written offer pursuant to the good faith negotiations under this Section 10.7.3, the fees and
expenses of such Valuation Firm shall be paid by PEGA1. 
 If PEGA1 completes the Strategic Transaction and the Compound and Products are the only assets in
clinical development Controlled by PEGA 1 at the time of the Strategic Transaction, the minimum value to be allocated to Compound and Products is [####]. 

This Section 10.7.3 does not apply if PEGA 1 completes the Strategic Transaction and the Compound and Products are the only assets Controlled by PEGA1 at
the time of the Strategic Transaction. In such case, the value associated with the Compound and Products is [####]. 

  
 28 

 10.8 IPO  

10.8.1 Shares issued to Roche 
 Immediately upon the IPO
Effective Time, provided that PEGA1 has not, as of the IPO Effective Time, entered into a Strategic Transaction involving the sale, license, transfer or other disposition of all rights relating to Compound and Products in all countries of the
Territory and the entire Field, PEGA 1 shall issue a number of its shares of common stock to Roche or its Affiliates as follows: 
 (i) If the IPO
Effective Time occurs before PEGA 1 has raised Private Financing in addition to the [####] stipulated in PEGA1’s Series A Agreement, immediately prior to the IPO (and conditional upon the IPO actually proceeding) Roche shall be granted a number
of shares of PEGA1’s common stock such that Roche shall own [####] of the fully diluted share capital of PEGA 1 immediately prior to the completion of the IPO (i.e., such that Roche’s fully diluted ownership of PEGA1 shall be [####] prior
to the sale of shares to the general public pursuant to an IPO). 
 (ii) If the IPO Effective Time occurs after PEGA1 has raised Private Financing in
addition to the [####] stipulated in PEGA1’s Series A Agreement, immediately prior to the IPO (and conditional upon the IPO actually proceeding) Roche shall be granted a number of shares of PEGA1’s common stock such that Roche shall own
[####] of the fully diluted share capital of PEGA1 immediately prior to the completion of the IPO (i.e., such that Roche’s fully diluted ownership of PEGA1 shall be [####] prior to the sale of shares to the general public pursuant to an IPO).

 The issuance of shares to Roche in an IPO pursuant to this Section 10.8.1 is in addition to all payments made by PEGA 1 pursuant to Sections 10.1,
10.2, 10.3 and 10.4 above with no right to offset. 
 No issuance of shares to Roche in an IPO shall be due if PEGA1 completes a Strategic Transaction
involving the sale, license, transfer or other disposition of all rights relating to Compound and Products in all countries of the Territory and the entire Field prior to the IPO Effective Time. 

10.8.2 Other assets or rights owned or controlled by PEGA1 

If at the IPO Effective Time, PEGA1 owns or controls (whether through a license or otherwise) other assets or rights (related to other pharmaceutical
development candidates or products) in addition to rights in the Compound or Products, then the Parties shall negotiate and agree in good faith the value contribution of Compound or Products to the IPO market capitalization in order to determine a
potential reduction of the percentage of Roche shares in PEGA1. 
 This notwithstanding, if Compound and Products are the only assets in clinical
development Controlled by PEGA1 at the IPO Effective Time, the minimum value to be allocated to Compound and Products is. 
 This Section 10.8.2 does
not apply if PEGA1 does an IPO and the Compound and Products are the only assets Controlled by PEGA1 at the time of the IPO. In such case, the value associated with the Compound and Products is [####]. 

  
 29 

 10.9 Third Party Payments  

Following the Effective Date, PEGA1 shall be responsible for and pay or have paid any and all consideration owed to any Third Party in relation to Third Party
intellectual property rights related to any Compound or Product and Roche confirms it has paid all consideration to any Third Party in relation to Third Party intellectual property rights related to any Compound or Products which became payable
prior to the Effective Date. For clarity, PEGA1 shall have no right of offset to any payments under Section 10 except as set out in clause 10.4a (Reductions). 

11. Accounting and reporting 
 11.1
Timing of Payments  
 PPEGA1 shall calculate royalties on Net Sales quarterly as of March 31, June 30, September 30 and
December 31 (each being the last day of an “Accounting Period”) and shall pay royalties on Net Sales within [####]after the end of each Accounting Period in which such Net Sales occur. 

11.2 Late Payment  
 Any payment under
this Agreement that is not paid after a first formal notice shall bear interest, to the extent permitted by Applicable Law, at an annual rate of [####]above the average [####]Euro Interbank Offered Rate (EURIBOR), as reported by Reuters from time to
time, calculated on the number of days such payment is overdue. 
 11.3 Method of Payment  

Royalties on Net Sales and all other amounts payable by PEGA1 hereunder shall be paid by PEGA1 in US Dollars (the “Payment Currency”) to
account(s) designated by Roche. 
 11.4 Currency Conversion  

When calculating the Sales of any royalty-bearing Product that occur in currencies other than the Payment Currency, PEGA1 shall convert the amount of such
sales into the Payment Currency using the rate published by the European Central Bank. 
 11.5 Reporting  

With each payment PEGA1 shall provide Roche in writing for the relevant Calendar Quarter on a
Product-by-Product basis the following information: 
  

	(a)	 Invoiced sales in local currency on a
country-by-country basis; 

  

	(b)	 Net Sales in local currency on a
country-by-country basis; 

  

	(c)	 Net Sales in USD on a
country-by-country basis; 

  

	(d)	 adjustments made pursuant to Section 10.5 (Combination Product); 

 

	(e)	 Net Sales in USD after adjustments made pursuant to Section 10.5 (Combination Product);

  

	(g)	 exchange rate used for the conversion of Net Sales from local currency to USD pursuant to Section 11.4

  

	(i)	 royalty rate pursuant to Section 10.4; 

 

	(j)	 deductions made pursuant to Section 10.4a and 

 

	(k)	 total royalty payable in USD. 

  
 30 

 12. Taxes 

It is specified that all amounts set forth in this Agreement whatever the applicable currency are excluding VAT. 

Roche shall pay all sales, turnover, income, revenue, value added, and other taxes levied on account of any payments accruing or made to Roche under this
Agreement. 
 If provision is made in law or regulation of any country for withholding of taxes of any type, levies or other charges with respect to any
royalty or other amounts payable under this Agreement to Roche, then PEGA1 shall promptly pay such tax, levy or charge for and on behalf of Roche to the proper governmental authority, and shall promptly furnish Roche with receipt of payment. PEGA1
shall be entitled to deduct any such tax, levy or charge actually paid from royalty or other payment due to Roche or be promptly reimbursed by Roche if no further payments are due to Roche. Each Party agrees to reasonably assist the other Party in
claiming exemption from such deductions or withholdings under double taxation or similar agreement or treaty from time to time in force and in minimizing the amount required to be so withheld or deducted. 

13. Auditing 
 13.1 Roche Right to
Audit  
 PEGA1 shall keep, and shall require its Affiliates and Sublicensees to keep, full, true and accurate books of account containing all
particulars that may be necessary for the purpose of calculating all (i) Net Sales and royalties, (ii) Proceeds and Strategic Transaction Revenues and (iii) any other payment made under this Agreement. Such books of accounts shall be
kept at their principal place of business. At the expense of Roche, Roche has the right to appoint one of the major public accountant firms to perform, on behalf of Roche an audit of such books and records of PEGA1 and its Affiliates and
Sublicensees, that are deemed necessary by the major public accountant firm to report on all (i) Net Sales and royalties, (ii) Proceeds and Strategic Transaction Revenues and (iii) any other payment made under this Agreement. 

Upon at least [####]prior written notice from Roche, such audit shall be conducted in the countries specifically requested by Roche, during regular business
hours in such a manner as to not unnecessarily interfere with PEGA1’s or its Sublicensees normal business activities, and shall be limited to results in the [####]prior to audit notification. 

Such audit shall not be performed more frequently than once per Calendar Year nor more frequently than once with respect to records covering any specific
period of time. 
 All information, data documents and abstracts herein referred to shall be used only for the purpose of calculating (i) Net Sales and
royalties, (ii) Proceeds and Strategic Transaction Revenues and (iii) any other payment made under this Agreement, and shall all be treated as PEGA1’s Confidential Information subject to the obligations of this Agreement and need
neither be retained more than [####]after completion of an audit hereof, if an audit has been requested; nor more than [####]from the end of the Calendar Year to which each shall pertain; nor more than [####]after the date of termination of this
Agreement. 

  
 31 

 13.2 Audit Reports  

The auditors shall only state factual findings in the audit reports and shall not interpret the agreement. The final audit report shall be shared with PEGA1 at
the same time it is shared with Roche. 
 13.3 Over-or Underpayment  

If the audit reveals an overpayment, Roche shall reimburse PEGA1 for the amount of the overpayment within [####]. If the audit reveals an underpayment, PEGA1
shall pay Roche for such underpayment within [####]. PEGA1 shall pay for the audit costs if the underpayment of PEGA1 exceeds [####]of the aggregate amount of royalty payments owed with regard to the royalty statements or other payments subject of
the audit. Section 11.2 (Late Payment) shall apply to this Section 13.3. 
 14. Intellectual Property 

14.1 Ownership of Inventions and Know-How  

PEGA1 shall own all PEGA1 Inventions. Roche shall own all Roche Inventions. Joint Inventions shall be jointly owned in equal undivided shares. PEGA1 and Roche
each shall require all of its employees to assign all inventions related to Products made by them to Roche and PEGA1, as the case may be. 
 The
determination of inventorship for Inventions shall be in accordance with US inventorship laws. 
 As for Joint Inventions, both Parties shall consult each
other and agree as to filing for patent protection on such invention as set forth above in their names. 
 Subject to the licenses granted under this
Agreement, each Party shall be free to exploit Joint Inventions, Joint Patent Rights and Joint Know-How without the consent of, or any duty to account to, the other Party, save for that Roche in relation to
the Compound may only use such Joint Patent Rights and Joint Know-How for research purposes in accordance with clause 2.6 or outside the Field. 

Roche shall notify PEGA1 of any Roche Inventions as and when generated during the Agreement Term by Roche, and in sufficient detail to enable PEGA1 to assess
the Roche Invention. Roche hereby grants to PEGA1 an option (“Option”) exercisable at any time during [####]from the date of proper notification of the Roche Invention in question (“Option Period”) to
commence negotiation for the grant by Roche to PEGA1 of a license to Roche Inventions (“Roche Invention License”). 

  
 32 

 In the event that PEGA1 decides to exercise the Option the following provisions shall apply: (i) PEGA1
shall serve on Roche a written notice to be received by Roche within the Option Period and the Parties shall enter into bona fide negotiations to enter into the Roche Invention License which shall be faithful to the principles as set forth in this
Agreement; (ii) the Parties will use their best endeavours to ensure that such negotiations shall be completed and the Roche Invention License shall be executed within [####] (“Negotiation Period”); and (iii) if
PEGA1 does not exercise its option during the Option Period or if PEGA1 and Roche are unable to agree the full terms of the Roche Invention License within the Negotiation Period the Option shall lapse. 

For the duration of the Option Period and any Negotiation Period Roche shall not assign, transfer, grant licenses of or permit use by any third party of Roche
Inventions. 
 Except as specifically set forth herein, this Agreement shall not be construed as (i) giving any of the Parties any license, right,
title, interest in or ownership to the Confidential Information; (ii) granting any license or right under any intellectual property rights; or (iii) representing any commitment by either Party to enter into any additional agreement, by
implication or otherwise. 
 14.2 German Statute on Employee’s Inventions  

If the German Statute on Employees’ Inventions applies, e.g. if a Party or its Affiliate is organized under German Law, each Party agrees to claim the
unlimited use of any Invention conceived, reduced to practice, developed, made or created in the performance of, or as a result of, any research by employees of said Party or its Affiliate or any other person acting on its behalf. For the avoidance
of doubt, said Party or its Affiliate is responsible for fulfilling the obligations towards their employees under the German Statute of Employee’s Inventions. 

14.3 Trademarks  
 PEGA1 shall have the
right to determine the trademark(s) for the Products and shall own all trademarks used on or in connection with Products in the Territory, and shall, at its sole cost, be responsible for procurement, maintenance, enforcement and defense of all
trademarks used on or in connection with Products in the Territory. 
 PEGA1 shall not use the Housemark(s) of Roche for any purposes. 

14.4 Prosecution of Roche Patent Rights  

Roche shall Handle all Roche Patent Rights. Roche shall consult with PEGA1 as to the Handling of Roche Patent Rights, shall allow reasonable time for such
consultation and have regard to all reasonable comments of PEGA1. PEGA1 shall pay the costs for the Handling of Roche Patent Rights. 
 For the avoidance of
doubt, Roche shall Handle Roche Glycoengineering Technology Patent Rights and Patent Rights in Roche Inventions within its sole discretion and at its own cost. 

Both parties shall inform each other on a regular basis on the status of Roche Patent Rights, Roche Glycoengineering Technology Patent Rights, Patent Rights
in Roche Inventions, PEGA1 Patent Rights, Patent Rights in PEGA1 Inventions or Joint Patent Rights, as the case may be. 

  
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 14.5 Prosecution of PEGA1 Patent Rights and Joint Patent Rights  

PEGA1 shall, at its own expense and discretion, Handle all PEGA 1 Patent Rights, Patent Rights in PEGA1 Inventions and Joint Patent Rights. PEGA1 shall consult
with Roche as to the Handling of Joint Patent Rights, shall allow reasonable time for such consultation and have regard to all reasonable comments of Roche. 

14.6 Patent Coordination Team  
 Where the
Parties need to consult with each other on the Handling of Patent Rights, the Parties shall establish a patent coordination team and shall adopt procedures for interacting on patent matters. 

14.7 Abandonment of Patent Rights  

Should Roche decide that it does not desire to Handle any Roche Patent Right under the Agreement, it shall promptly advise PEGA1 thereof and cease any payments
relating to the Handling of such Patent Right after two months following such advice. At the written request of PEGA1, Roche shall, at no cost to Roche, assign such patent in such country or countries in the Territory to PEGA1, and PEGA1 may
thereafter Handle the same at PEGA1’s own cost, to the extent that PEGA1 desires to do so. All Patent Rights so assigned from Roche to PEGA1 shall no longer be treated as Roche Patents for purposes of determining the Royalty Term. 

Should PEGA1 decide that it does not desire to Handle a PEGA1 Patent Right, a Joint Patent Right, or a Patent Right in a PEGA1 Invention, it shall promptly
advise Roche thereof. At the written request of Roche, PEGA1 shall then, at no cost to PEGA1, assign such patent in such country or countries in the Territory to Roche, and Roche may thereafter Handle the same at Roche’s own cost, to the extent
that Roche’s desires to do so. 
 14.8 Infringement  

Each Party shall promptly provide written notice to the other Party during the Agreement Term of any (i) known infringement or suspected infringement by a
Third Party of any Roche Patent Rights, PEGA1 Patent Rights or Joint Patent Rights, or (ii) known or suspected unauthorized use or misappropriation by a Third Party of any Roche Know-How, PEGA1 Know-How or Joint Know- How, and shall provide the other Party with all evidence in its possession supporting such infringement or unauthorized use or misappropriation. 

Within [####]after PEGA1 provides or receives such written notice (“Decision Period”), PEGA1, in its sole discretion, shall decide whether or
not to initiate such suit or action in the Territory and shall notify Roche in writing of its decision (“Suit Notice”). 
 If PEGA1 decides
to bring a suit or take action, once PEGA1 provides Suit Notice, PEGA1 may immediately commence such suit or take such action. In the event that PEGA1 (i) does not in writing advise Roche within the Decision Period that PEGA1 will commence suit or
take action, or (ii) fails to commence suit or take action within a reasonable time after providing Suit Notice, Roche shall thereafter have the right to commence suit or take action in the Territory and shall provide written notice to PEGA1 of
any such suit commenced or action taken by Roche. 

  
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 Notwithstanding the above, in relation to Roche Patent Rights PEGA1’s right to bring a suit or take
action shall depend upon Roche’s prior written approval, which shall not be unreasonably withheld or delayed (and if no written response for consent from Roche is received by PEGA1 within [####], such consent shall be deemed given). 

Upon written request, the Party bringing suit or taking action (“Initiating Party”) shall keep the other Party informed of the status of any
such suit or action and shall provide the other Party with copies, to the extent the Initiating Party is lawfully permitted to do so, of all substantive documents or communications filed in such suit or action. The Initiating Party shall have the
sole and exclusive right to select counsel for any such suit or action. 
 The Initiating Party shall, except as provided below, pay all expenses of the
suit or action, including the Initiating Party’s attorneys’ fees and court costs and damages owed to Third Parties. 
 Any damages, settlement fees
or other consideration received as a result of such suit or action shall be allocated as follows: 
 (a) First, to reimburse the Initiating Party for
its costs and, if any remains, to the other Party for any advisory counsel fees and costs; and 
 (b) Second, the balance, if any, shall be allocated to
the Initiating Party. 
 If the Initiating Party believes it is reasonably necessary or desirable to obtain an effective remedy, upon written request the
other Party agrees to be joined as a party to the suit or action but shall be under no obligation to participate except to the extent that such participation is required as the result of its being a named party to the suit or action. At the
Initiating Party’s written request, the other Party shall offer reasonable assistance to the Initiating Party in connection therewith at no charge to the Initiating Party except for reimbursement of reasonable out-of-pocket expenses incurred by the other Party in rendering such assistance. The other Party shall have the right to participate and be represented in any such suit or action by its own counsel at its own
expense. 
 The Initiating Party may settle, consent judgment or otherwise voluntarily dispose of the suit or action (“Settlement”)
without the written consent of the other Party but only if such Settlement can be achieved without adversely affecting the other Party (including any of its Patent Rights). If a Settlement could adversely affect the other Party, then the written
consent of the other Party would be required, which consent shall not be unreasonably withheld. 
 For any PEGA1 Patent Rights, PEGA1, in its sole
discretion, shall decide whether or not to initiate any suit or action in the Territory. PEGA1 shall have full discretion as to how it wishes to handle such suit or action and may reach Settlement and retain all damages, settlement fees or other
consideration under any terms and conditions it desires and retain whatever. Only if a Settlement could adversely affect Roche shall the written consent of Roche be required, which consent shall not be unreasonably withheld. 

For clarity, this Section 14.8 shall not apply to the Lonza Agreement. 

  
 35 

 14.9 Defense  

If a Third Party asserts that Patent Rights owned by or licensed to it are infringed by the development, manufacture, use, importation, offer for sale or sale
of Products, or that its trade secrets were misappropriated in connection with such activity, then PEGA1 shall have the exclusive right and responsibility to resolve any such claim, whether by obtaining a license from such Third Party, by defending
against such Third Party’s claims or otherwise, and shall be solely responsible for the defense of any such action, any and all costs incurred in connection with such action (including, without limitation, attorneys’ and expert fees) and
all liabilities incurred in connection therewith. Notwithstanding the above, PEGA1 shall not enter into any settlement of any such claim without the prior written consent of Roche if such settlement would require Roche to be subject to an injunction
or to make any monetary payment to PEGA1 or any Third Party, or admit any wrongful conduct by Roche or its Affiliates, or would limit or restrict the claims of or admit any invalidity and/or unenforceability of any of the Patent Rights Controlled by
Roche, or have any impact on activities outside the Field. Such Roche consent shall not be unreasonably withheld or delayed. . 
 14.10
Common Interest Disclosures  
 With regard to any information or opinions disclosed pursuant to this Agreement by one Party to the other regarding
intellectual property and/or technology owned by Third Parties, the Parties agree that they have a common legal interest in determining whether, and to what extent, Third Party intellectual property rights may affect Compounds and/or Products, and
have a further common legal interest in defending against any actual or prospective Third Party claims based on allegations of misuse or infringement of intellectual property rights relating to the Compounds and/or Products. Accordingly, the Parties
agree that all such information and materials obtained by PEGA1 and Roche from each other will be used solely for purposes of the Parties’ common legal interests with respect to the conduct of the Agreement. All information and materials will
be treated as protected by the attorney-client privilege, the attorney-work product privilege, and any other privilege or immunity that may otherwise be applicable. By sharing any such information and materials, neither Party intends to waive or
limit any privilege or immunity that may apply to the shared information and materials. Neither Party shall have the authority to waive any privilege or immunity on behalf of the other Party without such other Party’s prior written consent, nor
shall the waiver of privilege or immunity resulting from the conduct of one Party be deemed to apply against any other Party. 
 PEGA1 is responsible to
perform due diligence and to secure its own freedom to operate study or opinion in connection with the manufacture, use, sale, offer for sale and importation of the Compound and Products from counsel of PEGA1’s choice. 

14.11 Patent Term Extensions  
 The
Parties shall use Commercially Reasonable Efforts to obtain all available patent term extensions, adjustments or restorations, or supplementary protection certificates with respect to any Patent Rights Covering the Compound or Products
(“SPCs”, and together with patent term extensions, adjustments and restorations, “Patent Term Extensions”). Both Parties shall consult each other and agree as to filing for such Patent Term Extensions ..
Notwithstanding the above, 

  
 36 

 
filings for Patent Term Extension of Roche Glycoengineering Technology Patent Rights shall be made by Roche at Roche’s discretion. Each Party shall execute such authorizations and other
documents and take such other actions as may be reasonably requested by the other Party to obtain such extensions. The Parties shall cooperate with each other in gaining patent term restorations, extensions and/or SPCs wherever applicable to Roche
Patent Rights. 
 15. Representations and Warranties (Zugesicherte Eigenschaften) 

15.1 Mutual representations and warranties  

Each Party represents and warrants to the other that, as of the Effective Date: (a) it is duly organized and validly existing under the laws of its
jurisdiction of incorporation or formation, and has full corporate or other power and authority to enter into this Agreement and to carry out the provisions hereof; (b) it is duly authorized to execute and deliver this Agreement and to perform
its obligations hereunder, and the person or persons executing this Agreement on its behalf has been duly authorized to do so by all requisite corporate or partnership action; and (c) this Agreement is legally binding upon it, enforceable in
accordance with its terms, and does not conflict with any agreement, instrument or understanding, oral or written, to which it is a party or by which it may be bound, nor violate any material law or regulation of any court, governmental body or
administrative or other agency having jurisdiction over it. 
 15.2 PEGA1 representations and warranties  

PEGA1 represents and warrants that for the execution, delivery and performance of this Agreement by Roche and PEGA1, PEGA 1 complies with internationally
recognized human rights (including, as a minimum, the International Covenants on Economic, Social and Cultural Rights [ICESCR] I and II and the eight core conventions of the International Labour Organization [ILO]) and environmental standards
(including for example the Montreal Protocol on Substances that Deplete the Ozone Layer, the International Finance Corporation [IFC]’s Environmental and Social Performance Standards or standards developed by the International Organization for
Standardization ([ISO]) (“International Standards”) and shall ensure that such International Standards shall apply to its Affiliates, Sublicensees and subcontractors. Roche reserves the right to conduct corresponding audits at the
facilities of PEGA1, its Affiliates, its Sublicensees or its subcontractors as applicable and PEGA1 shall use its best endeavours to ensure that Roche is entitled to conduct such audits at such facilities. 

15.3 Roche Representations and Warranties  

Roche represents and warrants to PEGA1 that, as of the Effective Date: (a) Roche has not received written notice from any Third Party claiming that the
manufacture, use or sale of Compound or Product infringes any Patent Right of any Third Party; (b) Roche is not a party to any legal action, suit or proceeding relating to Compound or Product; (c) Roche has the full right, power and
authority to grant all of the right, title and interest in the sub-licenses and other rights granted to PEGA1 under this Agreement; (d) Roche has Control of all the Roche Patent Rights, Roche
Glycoengineering Technology Patent Rights, Roche Know-How licensed to PEGA1 under this Agreement; and (e) the Lonza Agreement is in full force and effect. 

  
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 15.4 Disclaimer  

Except as expressly set forth herein and elsewhere in this Agreement, the intellectual property rights provided by each party hereunder are provided “as
is” and each party expressly disclaims any and all warranties of any kind, express or implied, including without limitation the warranties of design, merchantability, fitness for a particular purpose,
non-infringement of the intellectual property rights of third parties, or arising from a course of dealing, usage or trade practices. 

16. Indemnification 
 16.1 Roche
indemnification  
 Roche shall indemnify and defend PEGA1 and its Affiliates and its respective officers, directors, employees, consultants and agents
(“PEGA1 Indemnitees”) from and against any and all losses, damages, liabilities, expenses and costs, including reasonable legal expense and attorneys’ fees (“Indemnified Losses”), to which any such PEGA1
Indemnitee may become subject as a result of any claim, demand, action or other proceeding by any Third Party to the extent such Indemnified Losses arise out of the breach by Roche of any obligation, representation, warranty, covenant or agreement
made by it under this Agreement, except to the extent such Indemnified Losses result from the negligence or willful misconduct of any PEGA1 Indemnitee (including without limitation any item subject to indemnification by PEGA1 under
Section 16.2). 
 16.2 PEGA1 indemnification  

PEGA1 shall indemnify and defend Roche and its Affiliates and its respective officers, directors, employees, consultants and agents (“Roche
Indemnitees”) from and against any and all Indemnified Losses, to which any such Roche Indemnitee may become subject as a result of any claim, demand, action or other proceeding by any Third Party to the extent such Indemnified Losses arise
out of (i) the breach by PEGA1 of any obligation, representation, warranty, covenant or agreement made by it under this Agreement, or (ii) the development, manufacture, use, handling, storage, sale or other disposition of the Compound
and/or any Products by PEGA1 or any of its Affiliates or Partners (including but not limited to (1) Product liability claims, (2) infringement of Third Party Patent Rights, other than those for this clause (3) Patents sub-licensed to PEGA1 by Roche under the Lonza Agreement, provided that PEGA1 has complied with the applicable terms of this Agreement), except to the extent such Indemnified Losses result from the negligence or
willful misconduct of any Roche Indemnitee (including without limitation any item subject to indemnification by Roche under Section 16.1). 

16.3 Procedure  
 In the event any PEGA1
Indemnitee or Roche Indemnitee (as the case may be) seeks indemnification under Section 16.1 or 16.2, it shall inform the other Party (the “Indemnifying Party”) of a claim as soon as reasonably practicable after it receives
notice of the claim, shall permit the Indemnifying Party to assume direction and control of the defense of the claim (including the right to settle the claim solely for monetary consideration), and shall cooperate as requested (at the expense of the
Indemnifying Party) in the defense of the claim, provided that the Indemnifying Party shall not settle any such claim without the prior written consent of any affected Roche Indemnitee or PEGA1 Indemnitee (as the case may be), if such settlement
contains any admission of fault of such PEGA1 Indemnitee or Roche Indemnitee (as the case may be). 

  
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 17. Liability 

17.1 Disclaimer  
 The foregoing
representations and warranties are in lieu of all other representations and warranties not expressly set forth herein. PEGA1 and Roche disclaim all other warranties, whether express or implied, with respect to each of their research, development and
commercialization efforts hereunder, including, without limitation, whether the products can be successfully developed or marketed, the accuracy, performance, utility, reliability, technological or commercial value, comprehensiveness,
merchantability or fitness for any particular purpose whatsoever of the products. 
 17.2 Limitation of Liability  

Each party’s total aggregate liability to the other under or in connection with this Agreement including the warranty liability and indemnification/hold
harmless liability (whether in contract, tort including negligence, breach of statutory duty, restitution or otherwise) in respect of all and any loss or damage howsoever caused will be limited to the amount paid under this Agreement. 

In no event shall either party be liable for indirect damages (Indirekte Schäden/weitere Schäden als Schäden mit langem Kausalzusammenhang),
consequential damages (Mangelfolgeschaden) including lost revenues or profits (entgangener Gewinn), irrespective of the legal basis for such claims. This limitation of liability shall not apply in the event of damages caused by gross negligence or
willful misconduct of the damaging party. 
 18. Obligation Not to Disclose Confidential Information 

18.1 Non-Use and Non-Disclosure  

During the Agreement Term and for [####] thereafter, a Party receiving Confidential Information (“Receiving Party”) shall (i) treat
Confidential Information provided by Disclosing Party as it would treat its own information of a similar nature, (ii) take all reasonable precautions not to disclose such Confidential Information to Third Parties, without the Disclosing
Party’s prior written consent, and (iii) not use such Confidential Information other than for fulfilling its obligations under this Agreement. PEGA1 shall be permitted to disclose Confidential Information to its Affiliates so long as such
Affiliate is bound by obligations of confidentiality in respect of the Confidential Information. 
 18.2 Permitted Disclosure  

Notwithstanding the obligation of non-use and non-disclosure set forth in
Section 18.1, the Parties recognize the need for certain exceptions to this obligation, specifically set forth below, with respect to press releases, Patent Rights, publications, and certain commercial considerations. 

  
 39 

 18.3 Press Releases  

Either Party may issue a press release announcing the existence and selected key non-financial terms of this Agreement,
upon prior approval by the other Party. 
 Either Party shall provide the other Party with a copy of any draft press release related to the activities
contemplated by this Agreement at least [####] prior to its intended publication for review. Either Party may provide the other Party with suggested modification to the draft press release. 

Notwithstanding the foregoing, Roche may issue press releases consistent with its internal policies. 

18.4 Publications  
 During the Agreement
Term, the following restrictions shall apply with respect to disclosure by any Party of Confidential Information relating to the Compound and Products in any publication or presentation: 

A Party (“Publishing Party”) shall provide the other Party with a copy of any proposed publication or presentation at least [####] (or at
least [####]in the case of oral presentations) prior to submission for publication so as to provide such other Party with an opportunity to recommend any changes it reasonably believes are necessary to continue to maintain the Confidential
Information disclosed by the other Party to the Publishing Party in accordance with the requirements of this Agreement. The incorporation of such recommended changes shall not be unreasonably refused; and if such other Party notifies
(“Publishing Notice”) the Publishing Party in writing, within [####] days after receipt of the copy of the proposed publication or presentation (or at least [####]) days in the case of oral presentations), that such publication or
presentation in its reasonable judgment (i) contains an invention, solely or jointly conceived and/or reduced to practice by the other Party, for which the other Party reasonably desires to obtain patent protection or (ii) could be
expected to have a material adverse effect on the commercial value of any Confidential Information disclosed by the other Party to the Publishing Party, the Publishing Party shall prevent such publication or delay such publication for a mutually
agreeable period of time. In the case of inventions, a delay shall be for a period reasonably sufficient to permit the timely preparation and filing of a patent application(s) on such invention, and in no event less than [####] from the date of the
Publishing Notice. 
 18.5 Commercial Considerations  

Nothing in this Agreement shall prevent PEGA1 or its Affiliates from disclosing Confidential Information of Roche to (i) governmental agencies to the
extent required or desirable to secure government approval for the development, manufacture or sale of Products in the Territory, (ii) Third Parties acting on behalf of PEGA1, to the extent necessary for the development, manufacture or sale of
Products in the Territory, (iii) Third Parties to the extent necessary to market any Product in the Territory, (iv) Third Parties to the extent necessary in connection with a prospective or actual Partner Agreement, (v) Third Parties
to the extent necessary to otherwise carry out its obligations or exercise its rights under this Agreement, (vi) with a prospective or actual financing, investment in or Change of Control of PEGA1, provided that any such disclosures are subject
to confidentiality obligations at least as onerous as those set forth in this Agreement or (vii) Third Parties in connection with any IPO of PEGA1, to the extent PEGA1 deems such disclosure necessary. 

  
 40 

 The Receiving Party may disclose Confidential Information of the Disclosing Party to the extent that such
Confidential Information is required to be disclosed by the Receiving Party to comply with Applicable Law, to defend or prosecute litigation or to comply with governmental regulations or applicable regulations of a stock exchange, provided that the
Receiving Party provides prior written notice of such disclosure to the Disclosing Party and, to the extent practicable, takes reasonable and lawful actions to minimize the degree of such disclosure and to ensure such disclosed Confidential
Information is treated confidentially. 
 19. Term and Termination 

19.1 Commencement and Term  
 This
Agreement shall commence on the Effective Date and continue for the Agreement Term. 
 19.2 Termination  

19.3 Termination for Breach  
 A Party
(“Non-Breaching Party”) shall have the right to terminate this Agreement in its entirety in the event the other Party (“Breaching Party”) is in breach of any of its
material obligations (relating to for example a breach of diligence, payments and / or compliance obligations) under this Agreement. The Non-Breaching Party shall provide written notice to the Breaching Party,
which notice shall identify the breach. The Breaching Party shall have a period of [####] after such written notice is provided (“Peremptory Notice Period”) to cure such breach. If the Breaching Party has a bona fide
dispute as to whether such breach occurred or has been cured, it will so notify the Non-Breaching Party together with an explanation for the basis of its dispute, and the expiration of the Peremptory Notice
Period shall be tolled until such dispute is resolved pursuant to Section 22.2. Upon a determination of breach or failure to cure, the Breaching Party may have the remainder of the Peremptory Notice Period to cure such breach. If such breach is
not cured within the Peremptory Notice Period, then absent withdrawal of the Non-Breaching Party’s request for termination, this Agreement shall terminate effective as of the expiration of the Peremptory
Notice Period. 
 19.4 Termination for Insolvency Event  

A Party shall have the right to terminate this Agreement in its entirety, if the other Party incurs an Insolvency Event; provided, however, in the case of any
involuntary bankruptcy proceeding, such right to terminate shall only become effective if the Party that incurs the Insolvency Event consents to the involuntary bankruptcy or such proceeding is not dismissed within [####] after the filing thereof.

 19.5 Termination by PEGA1 without a Cause  

PEGA1 shall have the right to terminate this Agreement at any time in its entirety or on a Product-by-Product basis
upon [####] prior written notice before First Commercial Sale of the Product or upon [####]prior written notice after the First Commercial Sale of the Product. The effective date of termination under this Section 20.5 shall be the date [####]
as the case may be after PEGA1 provides such written notice to Roche. 

  
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 19.6 Consequences of Termination  

19.7 Termination by PEGA1 for Breach by Roche or Roche Insolvency  

Upon breach by Roche or Roche’s Insolvency, PEGA1 shall have the right to terminate this Agreement in accordance with Section 20.3 or
Section 20.4, as applicable. Upon any termination by PEGA1 for breach by Roche or Roche Insolvency, the rights and licenses granted by one Party to the other Party under this Agreement shall terminate in their entirety or on a Product-by-Product basis, as applicable, on the effective date of termination. 

19.8 Termination by PEGA1 without cause, termination by Roche for Breach by 

PEGA1, PEGA1 Insolvency or PEGA1 Debarment  

Upon any termination by PEGA1 without cause, termination by Roche for Breach by PEGA1 (PEGA1 Insolvency or PEGA1 debarment, the rights and licenses granted by
Roche to PEGA1 under this Agreement shall terminate in their entirety, or on a Product-by Product basis, as applicable, on the effective date of termination. 

If Roche desires to continue development and/or commercialization of Product(s), Roche shall give PEGA1 the Continuation Election Notice within [####]of
receipt by Roche of PEGA1’s notice of termination. If PEGA1 receives such a timely Continuation Election Notice, and to the extent reasonably requested by Roche: 
  

	(a)	 After the date of notice of termination PEGA1 shall, to the extent PEGA1 has the right to do so, transfer to
Roche all regulatory filings and approvals, all final pre-clinical, non-clinical and clinical study reports and clinical study protocols, trademarks, and all data,
including clinical data, materials and information, in PEGA1’s possession and control related to Product(s) necessary or useful for Roche to continue to develop and commercialize the Product(s). 

 

	(b)	 PEGA1 shall assign all clinical study agreements, pre-clinical and non-clinical study agreements, CMC study agreements, free of charge; 

  

	(c)	 Roche shall, upon transfer, have the right to disclose such filings, approvals and data to
(i) governmental agencies to the extent required or desirable to secure government approval for the development, manufacture or sale of Product(s); (ii) Third Parties acting on behalf of Roche or its Affiliates PEGA1 for the development,
manufacture, or sale of Product(s), or (iii) Third Parties to the extent reasonably necessary to market Product(s). 

  

	(d)	 If the effective date of termination is prior to completion of the Phase II Study (conducted as proof of
concept study or Pivotal Study, as the case may be) of the first Product, Roche shall have a fully-paid up, royalty-free, worldwide, exclusive, sublicensable, transferable license under the PEGA1 Patent Rights, PEGA1
Know-How and PEGA1’s interest in the Joint Patent Rights including any rights useful or necessary to allow Roche, its Affiliates or licensees to research, develop, manufacture, have manufactured, use,
offer to sell, sell, promote, export and import the applicable Compound and Products. 

  
 42 

	(e)	 If the effective date of termination is after completion of the Phase II Study (conducted as proof of concept
study or Pivotal Study, as the case may be) of the first Product but prior to first Regulatory Approval of the first Product, Roche shall have a worldwide, exclusive, sublicensable, transferable license under the PEGA1 Patent Rights, PEGA1 Know-How and PEGA1’s interest in the Joint Patent Rights including any rights useful or necessary to allow Roche, its Affiliates or PEGA1 licensees to research, develop, manufacture, have manufactured, use,
offer to sell, sell, promote, export and import the applicable Compound and Products. Roche shall pay to PEGA1 a royalty of [####]of net sales of Product for [####]after the First Commercial Sale of the Product on a country-by- country basis. 

  

	(f)	 If the effective date of termination is after the first Regulatory Approval of the first Product, Roche shall
have a worldwide, exclusive, sublicensable, transferable license under the PEGA1 Patent Rights, PEGA1 Know-How and PEGA1 ‘s interest in the Joint Patent Rights including any rights useful or necessary to
allow Roche, its Affiliates or PEGA1 licensees to research, develop, manufacture, have manufactured, use, offer to sell, sell, promote, export and import the applicable Compound and Products. Roche shall pay to PEGA1 a royalty of [####] of net sales
of Product for [####]after the First Commercial Sale of the Product on a country-by-country basis. For example if the Product is transferred to Roche after
[####]following the First Commercial Sale of the Product in the US, then Roche shall pay to PEGA1 a royalty in the US for [####]. 

19.9 Obligations Related to Ongoing Activities  

If Roche does not provide timely Continuation Election Notice, then PEGA1 (a) shall have the right to cancel all cancellable ongoing obligations and
(b) shall complete all non-cancellable obligations at its own expense. 
 If Roche provides such timely
Continuation Election Notice, then from the date of notice of termination until the effective date of termination, PEGA1 shall continue activities ongoing as of the date of notice of termination at its own expense. 

After the effective date of termination, PEGA1 shall not have any obligation to perform and/or complete any activities or to make any payments for performing
or completing any activities under this Agreement, except as expressly stated herein. 
 19.10 Obligations Related to Manufacturing 

  

	(a)	 Clinical Supplies 

In the case of termination by Roche according to Sections 20.3, 20.4 or 22.5 or by PEGA1 under Section 20.3 or 20.5, if Roche elects to
develop the Product(s), upon the request of Roche, PEGA1 shall transfer all existing and available clinical material to Roche and Roche shall reimburse PEGA1 for this material at PEGA1’s fully burdened manufacturing cost, provided however that
PEGA1 shall procure the supply for the ongoing study(ies) until the transfer of the respective study and/or supply has been completed. PEGA1 shall use Commercially Reasonable Efforts to transfer the manufacturing and supply processes and
technologies to Roche or a Third Party defined by Roche as soon as possible after the effective date of termination at PEGA1 cost and provide Roche corresponding support free of charge until such processes and technologies have been fully
established at Roche or at the Third Party defined by Roche. 

  
 43 

	(b)	 Commercial Supplies 

In the case of termination by Roche according to Sections 20.3, 20.4 or 22.5 or by PEGA1 under Section 20.3 or 20.5, if a Product is
marketed or filed for Regulatory Approval in any country of Territory on the date of the notice of termination of this Agreement, upon the request of Roche, PEGA1 shall manufacture and supply such Product to Roche for a period that shall not exceed
[####] from the effective date of the termination of this Agreement and Roche shall reimburse PEGA1 for this material at PEGA1’s fully burdened manufacturing cost. PEGA1 shall use Commercially Reasonable Efforts to transfer the manufacturing
and supply processes and technologies to Roche or a Third Party defined by Roche as soon as possible after the effective date of termination at PEGA1 ‘s cost and provide Roche corresponding support until such processes and technologies have
been fully established at Roche or at the Third Party defined by Roche. 
 19.11 Ancillary Agreements  

Unless otherwise agreed by the Parties, the termination of this Agreement shall cause the automatic termination of all ancillary agreements related hereto.

 19.12 Direct License  
 Irrespective
of anything to the contrary in this Agreement, any existing, permitted sublicense granted to a Sublicensee shall, upon the written request of PEGA1 and Sublicensee within [####] following the effective date of termination, remain in full force and
effect until [####]from the effective date of termination of this Agreement (“Transition Period”), provided that (i) such Sublicensee is not then in breach of its sublicense agreement, and in the case of termination by Roche
for breach by PEGA1, that such Sublicensee did not cause the breach that gave rise to the termination by Roche. During such Transition Period, Roche shall cooperate with such Sublicensee to enter into a direct license agreement, whereby such
Sublicensee agrees in writing to be bound to Roche under the same terms and conditions of this Agreement. Notwithstanding the foregoing, any sublicense granted by PEGA1 under Section 2.2 of this Agreement to its Affiliates shall terminate upon
effective date of the termination of this Agreement. 
 19.13 Royalty and Payment Obligations  

Termination of this Agreement by a Party, for any reason, shall not release PEGA1 from any obligation to pay royalties or make any other payments to Roche that
are due and payable or accrued prior to the effective date of termination. 
 19.14 Survival  

Article 16 (Indemnification), Article 18 (Obligation Not to Disclose Confidential Information), Article 19 (Term and Termination) and Sections 14.1 (Ownership
of Inventions and Know-How), 14.2 (German Statute on Employee’s Inventions), 21.1 (Governing Law and Jurisdiction) shall survive any expiration or termination of this Agreement for any reason. 

  
 44 

 20. Bankruptcy 

All licenses (and to the extent applicable rights) granted under or pursuant to this Agreement by Roche to PEGA1 are, and shall otherwise be deemed to be, for
purposes of Section 365(n) of Title 11, US Code (the “Bankruptcy Code”) licenses of rights to “intellectual property” as defined under Section 101(60) of the Bankruptcy Code. Unless PEGA1 elects to terminate this
Agreement, the Parties agree that PEGA1 as a PEGA1 or Sublicensees of such rights under this Agreement, shall retain and may fully exercise all of its rights and elections under the Bankruptcy Code, subject to the continued performance of its
obligations under this Agreement. 
 21. Miscellaneous 

21.1 Governing Law and Jurisdiction  

This Agreement shall be governed by and construed in accordance with the laws of Switzerland, without reference to its conflict of laws principles, and shall
not be governed by the United Nations Convention of International Contracts on the Sale of Goods (the Vienna Convention) (“Governing Law”). The competent courts of Basel City shall have the exclusive jurisdiction. 

21.2 Disputes  
 Unless otherwise set
forth in this Agreement, in the event of any dispute in connection with this Agreement, such dispute shall be, by written notice (“Escalation Notice”) referred to the respective executive officers of the Parties designated below or
their designees, for good faith negotiations attempting to resolve the dispute. The designated executive officers are as follows: 
 For
PEGA1: CEO 
 For Roche: Head of Roche Pharma Partnering 

21.3 Insurance  
 PEGA1 shall purchase and
maintain throughout the Agreement Term insurance or indemnity protection that is co-equal with its indemnity obligations. This shall include, but not be limited to broad form commercial general liability
insurance (including product liability). The limit of liability for such coverage shall be no less than US Dollars [####] per claim/occurrence in the aggregate. PEGA1 shall also maintain workers’ compensation insurance. PEGA1 shall provide
Roche with written evidence of such insurances after the Effective Date and thereafter on yearly basis. 
 21.4 Assignment  

PEGA1 may not assign its rights or obligations under this Agreement absent the prior written consent of Roche, except that each Party may assign this Agreement
without such consent to any of its Affiliates or, however, subject to the terms and conditions of this Agreement, in the context of a merger, acquisition, sale or other transaction involving all or substantially all of the assets of PEGA1, in which
case PEGA1 in its sole discretion may assign its rights and obligations under this Agreement. Any permitted assignment shall be binding on the successors of PEGA1, 

  
 45 

 21.5 Debarment  

PEGA1 represents and warrants that it has never been debarred under 21 U.S.C. §335a, disqualified under 21 C.F.R. §312.70 or §812.119,
sanctioned by a Federal Health Care Program (as defined in 42 U.S.C §1320 a-7b(f)), including without limitation the federal Medicare or a state Medicaid program, or debarred, suspended, excluded or otherwise declared ineligible from any other
similar Federal or state agency or program. In the event PEGA1 receives notice of debarment, suspension, sanction, exclusion, ineligibility or disqualification under the above-referenced statutes, PEGA1 shall immediately notify Roche in writing and
Roche shall have the right, but not the obligation, to terminate this Agreement, effective, at Roche’s option, immediately or at a specified future date, with the consequences set forth in Section 19.8. 

21.6 Independent Contractor  
 No employee
or representative of either Party shall have any authority to bind or obligate the other Party to this Agreement for any sum or in any manner whatsoever or to create or impose any contractual or other liability on the other Party without said
Party’s prior written approval. For all purposes, and notwithstanding any other provision of this Agreement to the contrary, PEG A1 legal relationship to Roche under this Agreement shall be that of independent contractor. 

21.7 Unenforceable Provisions and Severability  

If any of the provisions of this Agreement are held to be void or unenforceable, then such void or unenforceable provisions shall be replaced by valid and
enforceable provisions that will achieve as far as possible the economic business intentions of the Parties. However the remainder of this Agreement will remain in full force and effect, provided that the material interests of the Parties are not
affected, i.e. the Parties would presumably have concluded this Agreement without the unenforceable provisions. 
 21.8 Waiver  

The failure by either Party to require strict performance and/or observance of any obligation, term, provision or condition under this Agreement will neither
constitute a waiver thereof nor affect in any way the right of the respective Party to require such performance and/or observance. The waiver by either Party of a breach of any obligation, term, provision or condition hereunder shall not constitute
a waiver of any subsequent breach thereof or of any other obligation, term, provision or condition. 
 21.9 Appendices  

All Appendices to this Agreement shall form an integral part to this Agreement. 

  
 46 

 21.10 Interpretation  

Except where the context expressly requires otherwise, (a) the use of any gender herein shall be deemed to encompass references to either or both genders,
and the use of the singular shall be deemed to include the plural (and vice versa), (b) the words “include”, “includes” and “including” shall be deemed to be followed by the phrase “without limitation”, (c)
the word “will” shall be construed to have the same meaning and effect as the word “shall”, (d) any definition of or reference to any agreement, instrument or other document herein shall be construed as referring to such
agreement, instrument or other document as from time to time amended, supplemented or otherwise modified (subject to any restrictions on such amendments, supplements or modifications set forth herein), (e) any reference herein to any Party or Third
Party or person shall be construed to include the Party’s or Third Party’s or person’s successors and assigns, (f) the words “herein”, “hereof” and “hereunder”, and words of similar import, shall be
construed to refer to this Agreement in its entirety and not to any particular provision hereof, (g) all references herein to Articles, Sections or Appendices shall be construed to refer to Articles, Sections or Appendices of this Agreement,
and references to this Agreement include all Appendices hereto, (h) the word “notice” means notice in writing (whether or not specifically stated) and shall include notices, consents, approvals and other written communications
contemplated under this Agreement, (i) provisions that require that a Party, the Parties or any Committee hereunder “agree”, “consent” or “approve” or the like shall require that such agreement, consent or approval
be specific and in writing, whether by written agreement, letter, approved minutes or otherwise (but excluding instant messaging), (j) references to any specific law, rule or regulation, or article, section or other division thereof, shall be deemed
to include the then-current amendments thereto or any replacement or successor law, rule or regulation thereof, and (k) the term “or” shall be interpreted in the inclusive sense commonly associated with the term “and/or.”

 21.11 Invoices  
 All invoices that
are required or permitted hereunder shall be in writing and sent by Roche to PEGA1 at the following address or other address as PEGA1 may later provide: 

PEGA-ONE SAS 
 For the attention
of the CEO 
 1 Mail du Professeur Georges Malthe, 

Villejuif Bio-Park, 

94800 Villejuif 
 France 

21.12 Notice  
 All notices that are
required or permitted hereunder shall be in writing and sufficient if delivered personally, sent by facsimile (and promptly confirmed by personal delivery, registered or certified mail or overnight courier), sent by nationally recognized overnight
courier or sent by registered or certified mail, postage prepaid, return receipt requested, addressed as follows: 
  

					
	      	 	if to PEGA1, to:	  	PEGA-ONE SAS
			
		 		  	For the attention of the CEO
			
		 		  	1 Mail du Professeur Georges Malthe,
			
		 		  	Villejuif Bio-Park,
			
		 		  	94800 Villejuif France

  
 47 

					
	      	 	if to Roche, to:	  	F. Hoffmann-La Roche Ltd
			
		 		  	Grenzacherstrasse 124
			
		 		  	4070 Basel
			
		 		  	Switzerland
			
		 		  	Attn: Legal Department
			
		 		  	Facsimile No.: [####]
			
		 		  	and: Hoffmann-La Roche Inc.
			
		 		  	150 Clove Road, Suite 8
			
		 		  	Little Falls
			
		 		  	New Jersey 07424, U.S.A.
			
		 		  	Attn. Corporate Secretary
			
		 		  	Facsimile No.: [####]

 or to such other address as the Party to whom notice is to be given may have furnished to the other Party in writing in
accordance herewith. 
 21.13 Condition Precedent  

This Agreement is subject to the closing of a Private Financing pursuant to the Series A First Tranche of the Series A Agreement (“Condition
Precedent’’). 
 PEGA1 shall use Commercially Reasonable Efforts to take, or cause to be taken, all reasonable actions and to do, or cause to be
done, all things necessary and appropriate to satisfy the Condition Precedent. No Party shall be entitled to refuse or delay the consummation of any of the transactions contemplated hereunder for any reason other than the non-satisfaction of any Condition Precedent. If (i) the Condition Precedent is not satisfied within [####] after the signature of this Agreement, and (ii) the [####] period is not extended by Roche, this
Agreement is null and void ab initio. If the Agreement would become null and void ab initio, neither Party shall have any rights against the other in respect thereof, except with respect to the payment of the Upfront Payment pursuant to
Section 10.1 which shall remain non-refundable, and provided that the confidentiality provisions in Section 18 be deemed to have been in effect throughout the aforementioned period and remain in
force for [####] thereafter. 
 [Signature Page Follows] 

  
 48 

 IN WITNESS WHEREOF, the Parties have entered into this Agreement as of the Effective Date. 

 

					
	PEGA-ONE SAS	 	    	  	
			
	  
	 		  	  

	Name:	 		  	Name:
	Title:	 		  	Title:

  

					
	F. Hoffmann-La Roche Ltd	 	    	  	
			
	 /s/ Vikas Kabra
	 		  	  

	Name: Vikas Kabra	 		  	Name: Barbara Schroeder
	Title: Head of Transaction Execellence	 		  	Title: Legal Counsel

  

	
	Hoffmann-La Roche Inc.
	
	 /s/ John Parise

	Name: John P. Parise
	Title: Authorized Signatory

  
 49 

 Appendix 1.65 

[####] 

  
 50 

 Appendix 1.66 

[####] 

  
 51 

 Appendix 1.66 

[####] 

  
 52 

 Appendix 1.67 

[####] 

  
 53 

 Appendix 2.2 

Lonza Agreement 

  
 54 

 TABLE OF CONTENTS 

RESTATED UMBRELLA RESEARCH AND 

LICENSE AGREEMENT 

BETWEEN 
 LONZA SALES AG

 AND 
 F. HOFFMANN-LA ROCHE LTD, HOFFMANN-LA 
 ROCHE INC. AND
GENENTECH, INC. 

  
 55 

 TABLE OF CONTENTS 

 

							
	 Article 1.
	  	 Definitions
	  	 	57	 
			
	 Article 2.
	  	 LICENSE
	  	 	64	 
			
	 Article 3.
	  	 TECHNOLOGY TRANSFER
	  	 	67	 
			
	 Article 4.
	  	 CONSIDERATION
	  	 	70	 
			
	 Article 5.
	  	 CONFIDENTIALITY
	  	 	76	 
			
	 Article 6.
	  	 PUBLICITY AND PUBLICATIONS
	  	 	77	 
			
	 Article 7.
	  	 INTELLECTUAL PROPERTY
	  	 	78	 
			
	 Article 8.
	  	 REPRESENTATIONS AND WARRANTIES
	  	 	79	 
			
	 Article 9.
	  	 INDEMNIFICATION
	  	 	80	 
			
	 Article 10.
	  	TERM AND TERMINATION	  	 	81	 
			
	 Article 11.
	  	DISPUTE RESOLUTION	  	 	82	 
			
	 Article 12.
	  	MISCELLANEOUS	  	 	83	 

  
 56 

 RESTATED UMBRELLA RESEARCH AND LICENSE AGREEMENT 

This RESTATED UMBRELLA RESEARCH AND LICENSE AGREEMENT (this “Agreement”) is made and entered into as of the 29th day of November, 2013, (the
“Effective Date”) by and between Lonza Sales AG, Münchensteioerstrasse 38, CH-4002 Basel, Switzerland (“Lonza”) and Genentech. Inc., a Delaware corporation having its
principal place of business at 1 DNA Way, South San Francisco, California. USA 94080 (“Genentech”) and F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, CH4070 Basel Switzerland and Hoffmann-La Roche Inc. 340 Kingsland Street, Nutley New Jersey 07110, USA (“Roche”) 

BACKGROUND 
 WHEREAS, Lonza owns or
has rights in certain patents, patent applications and know-how covering certain vectors, cell lines and media useful in the manufacture of biopharmaceutical products, as described below; 

WHEREAS, Lonza and Genentech entered into that certain license titled “License and Option Agreement” effective as of the 16th of
December 2005, as amended the 30th of March 2007 (the “License and Option Agreement”); 
 WHEREAS, Lonza and Roche entered into that
certain license titled “Umbrella Research and License Agreement” effective as of the 27th of October 2006, as amended (the “Umbrella Research and License Agreement”); and 

WHEREAS, Lonza. Roche and Chugai have entered into the 1st Amendment to the Umbrella Research and License Agreement on April 24, 2009 to include
Chugai as an Affiliate under the Umbrella Research and License Agreement; 
 Lonza. Roche and Genentech now wish to amend and restate certain terms of the
Umbrella Research and License Agreement and the License and Option Agreement 
 NOW, THEREFORE, in consideration of the mutual covenants,
agreements representations and warranties set forth herein, the Parties agree as follows: 
 ARTICLE 1. 

DEFINITIONS 
 1.1
“Affiliate” means, as to any person or entity, any other person or entity, which controls, is controlled by, or is under common control with such person or entity. A person or entity shall be regarded as in control of another entity
only if it owns or controls, directly or indirectly, (i) in the case of corporate entities at least fifty percent (50%) (or the maximum ownership interest permitted by law) of the equity securities in the subject entity entitled to vote in the
election of directors and. (ii) in the case of an entity that is not a corporation, at least fifty percent (50%) (or the maximum ownership interest permitted by law) of the equity securities or other ownership interests with the power to direct
the management and policies of such subject entity or entitled to elect the corresponding management authority, or such other relationship as. in fact, constitutes actual control. Notwithstanding the foregoing, unless expressly specified otherwise.
for the purposes of this Agreement, Chugai Pharmaceutical Co., Ltd, 1-1 Nihonbashi-Muromachi 2-Chome, Chuo-ku Tokyo 103-8324, Japan, and all entities controlled by it
(collectively, “Chugai”). shall not be considered an Affiliate of Licensee unless and until Licensee provides written notice to Lonza specifying Chugai as an Affiliate of Licensee and paying to Lonza the fee set forth in
Section 4.1.2. 

  
 57 

 1.2 “Agreement” is defined in the Introduction. 

1.3 “Back-up Formulation Product” is defined in Section 4.5.4. 

1.4 “Back-up GS Product” is defined in Section 4.3.4 

1.5 [Intentionally left blank]. 
 1.6 “BLA” means
a Biologies License Application and amendments thereto filed pursuant to (he requirements of the FDA, as defined in 21 CFR. § 600 et seq. for FDA approval of a Licensed Product and “sBLA” means a supplemental BLA. 

1.7 “Combination” is defined in Section 1.45. 

1.8 “Confidential Information” means all materials, Know How or other information, whether or not patentable, regarding a Party’s
technology, products business information or objectives, which is designated as confidential in writing by the disclosing Party, whether by letter or by use of an appropriate stamp or legend, prior to or at the time any such material, Know-How or other information is disclosed by the disclosing Party to the receiving Party. Notwithstanding the foregoing, materials, Know-How or other information that is
orally, electronically or visually disclosed by a disclosing Party, or is disclosed in writing without an appropriate letter, stamp or legend, shall constitute Confidential Information of the disclosing Party, if within thirty (30) days after
such disclosure, the disclosing Party delivers to the receiving Party a written document or documents describing the materials, Know How or other information as confidential and referencing the place and date of such oral electronic, visual or
written disclosure and the names of the persons to whom such disclosure was made. In addition to the foregoing Lonza Confidential Information shall only include that information of Lonza disclosed to Licensee in accordance with Section 3.1 or
3.2, or at Licensee’s written request and in accordance with Section 3.3. 
 1.9 “Control” or “Controlled’ means
with respect to intellectual property assets, that a party has the right to grant a license or sublicense to such assets as provided herein without violating the terms of any written agreement with any Third Party. 

1.10 “Covers” (including variations such as “Covered”, “Covering” and the like), means, with respect to a
particular Patent and in reference to a particular compound or product (whether alone or in combination with one or more other ingredients) that the manufacture, use, sale, offer for sale or importation of such compound or product in a country is
claimed by a Valid Claim of such Patent in that country 
 1.11 “Customer Cell Line” means any cell line developed by Licensee which
(a) incorporates any GS Know-How, Customer Modifications or subject matter claimed in a Patent within the GS Patents, or (b) is derived by Licensee from a Host Cell Line. 

  
 58 

 1.12 “Customer Modifications” means CMV Expression Vector(s) and GS Expression Vector(s)

 1.13 “Discontinued Formulation Product” is defined in Section 4.2.4. 

1.14 “Discontinued GS Product” is defined in Section 4.2.4. 

1.15 “Discontinued PFM Product” is defined in Section 4.3.5. 

1.16 “Dispute” is defined in Section 11.1. 

1.17 “Effective Date” is defined in the Introduction. 

1.18 “EMA” means the European Medicines Agency and any successor agency. 

1.19 “Exchange” is defined in Section 6.1. 

1.20 “FDA” means the United States Food and Drug Administration and any successor agency. 

1.21 “First Commercial Sale” means for each royalty bearing product, the first commercial sale in any country as part of a nationwide
introduction by Licensee or its Sublicensees. Sales for test marketing, clinical trial purposes or compassionate or similar use shall not be considered to constitute a First Commercial Sale. 

1.22 “Formulation Know-How” means that [####], as such
Know-How existed as of September 1, 2006. 
 1.23 “Formulation Product” means any product
(including without limitation any GS Product or PFM Product) researched, developed and/or commercialized by Licensee that contains a protein produced using the Formulation Know-How (including any modification
by Licensee to the Formulation Know-How). 
 1.24 “GMP” means the regulatory requirements for
current good manufacturing practices promulgated by the FDA under the FD&C Act, 21 C.F.R. §§ 210, 211 and 600 et seq. and under the PHS Act, 21 C.F.R. §§ 600-610, as the same may
be amended from time to time and with respect to the Licensed Product, the corresponding or similar laws, rules and regulations of (hose jurisdictions in which the Licensed Product is sold. 

1.25 “GS Product” means any product researched, developed and/or commercialized by Licensee that contains a protein produced by
Licensee’s use of GS System. 
 1.26 “GS System” means the following owned or Controlled by Lonza (or its Affiliates) us of the 16th of
December 2005 or during the Term: the (a) GS Standard Vectors, (b) Host Cell Lines, (c) GS Know-How contained in (i) manuals of operating procedures for the GS Standard Vectors and the Host
Ceil Lines, (ii) regulatory information on CD-ROM and (iii) vector nucleotide sequences, (d) GS Patents and (e) GS Updates, used either in combination or individually, as further described
upon delivery by Lonza to Licensee of the materials specified in Section 3.1 and/or as disclosed in the GS Patents 

  
 59 

 1.26.1 “GS Know-How” means the Know-How owned or Controlled by Lonza (or its Affiliates) as of the 6th of December 2005 or during the Term, that relate to the GS System. GS Know How shall not include any Protein-Free Know-How 
 1.26.2 “GS Patents” means (a) those patents and patent applications
listed on Exhibit 28 and any Patents corresponding thereto, owned or Controlled by Lonza (or its Affiliates), as of the 16th of December 2005 or during the Term, (b) any Patents owned or Controlled by Lonza (or its Affiliates), as of the 16th
of December 2005 or during the Term, that relate to [####], and/or GS Updates, and (c) any Patents owned or Controlled by Lonza (or its Affiliates), as of the Effective Dale or during the Term, that are necessary or otherwise useful to make,
have made, use sell, offer for sale, and/or import a GS Product GS Patents do not include any Protein-Free Patents. 
 1.26.3 “GS
Standard Vectors” mean the following proprietary Lonza vectors [####] provided by Lonza to Licensee in accordance with Article 3. 

1.26.4 “GS Updates” means any updates and information relating thereto (including without limitation modifications,
derivatives or improvements) to the GS Standard Vectors Host Cell Lines and/or other Know How owned or Controlled by Lonza (or its Affiliates) that are generally made available by Lonza to its other licensees of the GS
Know-How for no financial consideration 
 1.26.5 “Host Cell Lines” means Lonza s
proprietary cell lines originating from Lonza’s GMP cell banks provided to Licensee by Lonza in accordance with Article 3, including, but not limited to Lonza’s proprietary [####] cell line. 

1.27 “IFRS” shall mean International Financial Reporting Standards 

1.28 “Indemnitee” is defined in Section 9.3. 

1.29 “Indemnitor” is defined in Section 9.3 

1.30 “Joint Inventions” is defined in Section 7.1. 

1.31 “Know-How” means information or biological materials, including, without limitation, cells, cell
lines, genes, gene fragments, gene sequences, probes, DNA, RNA, cDNA libraries, proteins, peptides, polypeptides, plasmids, vectors, expression systems, organisms, biological substances, and any constituents, progeny or replications thereof or
therefrom, reagents, chemical compounds, inventions whether or not patentable, improvements, practices, formulae, trade secrets, techniques, methods, procedures, knowledge, skill, experience, results, test data (including, without limitation,
pharmacological, toxicological and clinical test data), analytical and quality control data and any information regarding marketing, pricing, distribution, cost, sales or manufacturing Know-How shall not
include any Patents. 
 1.32 “Liabilities” is defined in Section 9.1. 

1.33 “Licensed Product” means a GS Product, a PFM Product or a Formulation Product. 

  
 60 

 1.34 “Licensee” means Roche, Genentech and/or its Affiliates (subject to Section 1.1)

 1.35 “Licensee Indemnitee” is defined in Section 9.1. 

1.36 “Lonza” is defined in the Introduction. 

1.37 “Lonza Indemnitee” is defined in Section 9.2. 

1.38 “Marketing Approval Application” or “MAA” means BLA, sBLA, NDA, sNDA and any equivalent thereof in the United States or
any other country or jurisdiction in the Territory. 
 1.39 “Materials” is defined in Section 3.4. 

1.40 “Model Vector [####]” means the double gene vector comprising the GS Standard Vectors [####]product gene, provided to Licensee by Lonza
accordance with Article 3. 
 1.41 “Multi-Product Commercial License” is defined in Section 2.1.2. 

1.42 “NDA” means a New Drug Application and amendments thereto filed pursuant to the requirements of the FDA, as defined in 21 C.F.R. §
314 et seq., for FDA approval of a Licensed Product and “sNDA” means a supplemental NDA. 
 1.43 [####] 

(a) 
 (b) Licensed Products
Sold in Combinations. 
 (i) In the event that a Licensed Product is sold in combination (in the same package, including as a co-formulation) with one or more other active ingredients that are not the subject of this Agreement (for purposes of this Section 1.45(c), a “Combination”), the gross amount invoiced for such
Licensed Product shall be calculated by multiplying (he gross amount invoiced for such Combination by the fraction A/(A+B), where “A” is the gross amount invoiced for such Licensed Product sold separately and “B” is the gross
amount invoiced for such other active ingredient(s) sold separately. 
 (ii) In the event that such other active ingredient(s) are not sold
separately (but such Licensed Product is), the gross amount invoiced for such Licensed Product shall be calculated by multiplying the gross amount invoiced for such Combination by the fraction A/C, where “A” is the gross invoice amount for
such Licensed Product, and “C” is the gross invoice amount for the Combination. 
 (iii) In the event that such Licensed Product is
not sold separately, Net Sales for royalty calculations shall be determined by the Parties in good faith. 
 1.44 “Party” shall mean
Licensee or Lonza and when used in the plural, shall mean Licensee and Lonza. 

  
 61 

 1.45 “Patent(s)” mean (a) a US and corresponding foreign patent application (including
provisional application, division, refiling, continuation, continuation-in-part, reissue and reexamination thereof); and (b) any patent (including without
limitation, any substitution, extension, reissue, renewal, reexamination, patent of addition, supplementary protection certificate and inventors’ certificate) that has issued or may issue in the future from any patent application described in
Subsection (a) 
 1.46 “PFM Product” means any product (including without limitation any GS Products) researched, developed and/or
commercialized by Licensee that contains a protein produced using the Formulation Know-How, the PFM System, the Protein-Free Know-How and/or Protein Free Patents,
including without limitation PFM Know-How Products and PFM Patent Products, but excluding the use of any modification by Licensee to the Formulation Know-How. 

1.46.1 “PFM Know-How Product” means any PFM Product, which is not a PFM Patent
Product, but which was manufactured as a result of Licensee’s material use of Protein- Free KnowHow which Protein Free Know-How was Confidential information of Lonza prior to and in (he calendar year in
which such PFM Know-How Product achieved a particular event set forth in Section 4.3.1. 

1.46.2 “PFM Patent Product” means any PFM Product which the making, using, selling, offering for sale or importing would, but
for the license from Lonza, infringe a Valid Claim of any Patents within the Protein-Free Patents Controlled by Lonza. 
 1.47 “PFM System”
means the Protein-Free Feeds, Protein-Free Media, Protein Free Base Powders, Protein-Free Patents, Protein-Free Know-How, PFM Updates and the Supplements used either in combination oi individually, and the
Tropolone Patent, as further described upon delivery by Lonza to Licensee of the materials specified in Article 3 and/or as disclosed in the Protein-Free Patents, as further described in Exhibit 1.49. 

1.47.1 “Protein-Free Base Powders” means the powders set out in Exhibit 1.49. 

1.47.2 “Protein-Free Feeds” means the concentrated nutrient solutions used in order to maintain the growth and productivity of
mammalian cells, as more fully set out in Exhibit 1.49 
 1.47.3 “Protein-Free
Know-How” means Know-How owned or Controlled by Lonza (or its Affiliates) as [####], that relate to the PFM System. 

1.47.4 “Protein-Free Media” means the solutions of nutrients used in mammalian cell culture, as more fully set out in Exhibit
1.49. 
 1.47.5 “Protein-Free Patents” means (a) those patents and patent applications listed on Exhibit 1.49 and any
Patents corresponding thereto, owned or Controlled by Lonza (or its Affiliates), as of the Effective Date or during the Term, and (b) any Patents owned or Controlled by Lonza (or its Affiliates), as of the Effective Date or during the Term,
that directly relate io the Lonza Protein Free System and are generally made available by Lonza to its other licensees of the Lonza PFM Technology for no financial consideration. 

  
 62 

 1.47.6 “PFM Updates” means any updates (including without limitation
modifications, derivatives or improvements) to the PFM System and/or other Know-How relating thereto owned or Controlled by Lonza (or its Affiliates) that are generally made available by Lonza to its other
licensees of the Protein-Free Know-How for no financial consideration. 
 1.47.7
“Supplements” means the supplement solutions, as further described in Exhibit 1.49. 
 1.47.8 [####] 

1.48 “Phase II Clinical Trial” means a human clinical trial, for which the primary endpoints include a determination of dose ranges and/or a
preliminary determination of efficacy of a Licensed Product in patients being studied as described in 21 C.F.R. §312.21, or similar clinical study in a country other than the United States 

1.49 “Phase III Clinical Trial” means human clinical trial(s), the principal purpose of which is to establish safety and efficacy in patients
with (he disease being studied as required in 21 C.F.R §312.21(c) or sim lar clinical study in a country other than the United States. Phase III shall also include any other human clinical trial intended as a pivotal trial for regulatory
approval purposes whether or not such trial is a traditional Phase III trial. 
 1.50 “Research License” is defined in Section 2.1.1.

 1.51 [####]. 
 1.52 “sBLA” is defined in
Section 1.6. 
 1.53 “sNDA” is defined in Section 1.44. 

1.54 “Sublicensee” means an entity to which Licensee has licensed rights pursuant to this Agreement 

1.55 “Term” is defined in Section 10.1. 

1.56 “Territory” means worldwide. 
 1.57
“Third Party” means any entity other than Lonza or Licensee or their respective Affiliates. 
 1.58 “Third Party
Collaborator” means a Third Party that has entered into a written agreement with Licensee to conduct research. development, manufacture, and/or commercialization of a Licensed Product with, or on behalf of Licensee 

1.59 “Third Party Contractor” means a Third Party that has entered into a written agreement with Licensee to conduct research, development
and/or manufacturing of a product (including without limitation GS Products and/or PFM Products) on behalf of Licensee. 
 1.60 “Third Party
Licensee” means a Third Party that has entered into a written agreement with Licensee, under which agreement Licensee out-licensed a Licensed Product to such Third Party, which out-license includes the right of such Third Party to conduct research, development, manufacture, and commercialization of such Licensed Product in one or more territories of the world. 

  
 63 

 1.61 “Third Party-Lonza Agreement” is defined in Section 2.5. 

1.62 “Transfection Medium System” means the Transfection Base Powder, the Transfection Medium, Transfection Medium Patents and Transfection
Medium Know-How used either in combination or individually, as more fully set out in Exhibit 1.64. 

1.62.1 “Transfection Base Powder” means the powder referred to in Exhibit 1.64. 

1.62.2 “Transfection Medium” means the solutions of nutrients used in mammalian cell culture. 

1.62.3 “Transfection Medium Know-How” means any
Know-How specifically relating to the Transfection Medium. 
 1.62.4 “Transfection Medium
Patents” means any Patents owned or Controlled by Lonza (or its Affiliates), [####], that directly relate to the Lonza Transfection Medium System and are generally made available by Lonza to its other licensees. 

1.63 “Valid Claim” means an issued and unexpired claim of a Patent that has not been canceled, withdrawn or rejected and has not lapsed or
become abandoned or been declared invalid or unenforceable or been revoked by a court or agency of competent jurisdiction from which no appeal can be or has been taken 

ARTICLE 2. 
 LICENSE

  

	2.1	 Licenses. 

2.1.1 Research License Grant. Lanza hereby grants to Licensee a non-exclusive, royalty-free,
worldwide right and license under the GS System, the PFM System and the Transfection Medium System (whether individually or in combination) to make, use, and import (but not to sell or offer for sale) products and processes solely for research and
development purposes (including without limitation pre-clinical research and development of Licensed Products) (the “Research License”) 

2.1.2 Multi-Product Commercial License Grant. Lonza hereby grants to Licensee a non-exclusive,
sublicensable worldwide right aid license under the GS System, the PFM System and the Transfection Medium System (whether individually or in combination) to make, use, import, sell and offer for sale licensed Products (the “Multi-Product
Commercial License”) 
  

	2.2	 Sublicensing and Subcontracting. 

2.2.1 Sublicenses. In accordance with this section 2.2, Licensee may grant sublicenses of its rights under its license in
Section 2.1 to their respective 

  
 64 

 (a) Third Party Collaborators with respect to Licensed Products that are being researched
manufactured, developed and/or commercialized by such Third Party Collaborator with, or on behalf of. Licensee; and 
 (b) Third Party
Licensees with respect to Licensed Products that are being researched, manufactured, developed and commercialized by or on behalf of such Third Party Licensee. 

Licensee shall remain responsible for the activities conducted by its Third Party Collaborators and Third Party Licensees under such sublicenses 

2.2.2 Certain Terms. The grant of any such sublicence by Licensee shall be subject to the following: 

(a) Licensee shall ensure such sublicensee’s use of the GS System, the PFM System and the Transfection Medium System is undertaken
solely for the purpose of establishing a manufacturing process for Product, or producing Product, for Roche its Affiliates or the sublicensee’ and 

(b) The sublicensee shall not, by virtue of this Agreement, be granted any right or licence, either express or implied, under any patent
or proprietary right vested in Lonza or otherwise, to use the GS System, the PFM System and the Transfection Medium System other than for the purposes of establishing a manufacturing Process for Product or producing Product for Roche, its Affiliates
or the sublicensee and Roche and/or its Affiliates agree to ensure that such sublicensee shall not assign, transfer, further sublicense or otherwise make over the benefit or the burden of the rights granted to it pursuant to this Agreement; and 

(c) Any sublicence granted shall be expressly subject and subordinate to the terms of this Agreement, and it shall be Licensee’s
responsibility to ensure the strict adherence by any sublicensee hereunder to the terms and conditions of this Agreement; and 

(d) Licensee shall not disclose the Formulation Know-How in its entirely to sublicensees. On
certain occasions, however, a sublicensee will require access to elements of the Formulation Know-How for specific purposes. By way of illustration, a sublicensee may require details of the actual components
within the Formulation Know-How, but not the concentrations of those components, for the preparation of a regulatory Filing, or may require details of (he method of applying the Formulation Know-How, but not each individual element and/or their concentrations, for technical development purposes. In such individual cases as and when the need arises, and only upon the sublicensee’s written request
specifically identifying the person or persons to whom such disclosure is to be made, Licensee shall be permitted to provide to such persons, and only to such persons, such elements of the Formulation Know-How
as are required to meet the particular need identified in the request. 
 (e) After the grant of any sublicense pursuant to this
Section 2 Licensee shall inform Lonza of the grant of such sublicence, including details of any occasion where an element of the Formulation Know-How has been disclosed to a sublicensee. 

  
 65 

 2.2.3 Subcontracting. Subject to Sections 2.4 and 3.4, the rights granted under
Section 2.1 shall include the right to have such activities conducted by Third Party Contractors on behalf of Licensee, its Affiliates and their respective Third Party Collaborators and Third Party Licensees. Licensee shall remain responsible
for the activities conducted by all Third Party Contractors under such subcontracts 
 2.2.4 Survival of Sublicenses. In the event of
termination of this Agreement, with respect to those sublicenses granted by Licensee to its Third Party Collaborators and/or Third Party Licensees under the GS System, the PFM System and/or the Transfection Medium System pursuant to
Section 2.1, such sublicenses shall survive; provided, (a) such sublicense is consistent with the terms of this Agreement, and (b) the respective Sublicensee is not in material breach of such sublicense on the effective date of
termination of this Agreement Within [####]of such termination, Licensee and Lonza shall agree as to whether (i) Licensee shall continue to be responsible for each such sublicense, or (ii) such sublicense shall be novated to Lonza after an
agreed dale. 
 2.3 Model Vector [####]. 

2.3.1 Grant. Lonza hereby grants io Licensee a non-exclusive. royalty-free, worldwide right and
license under its rights in the Model Vector [####] to use the Model Vector [####] in connection with Licensee’s exercise of the Research License, but for the sole purpose of enabling Licensee to compare transfection efficiencies and expression
levels achieved using the Model Vector [####] with transfection efficiencies and expression levels achieved using Licensee’s genes and vectors of interest. 

2.3.2 Sublicenses. Licensee is specifically prohibited from granting a sublicense of its rights under its license in Section 2.3.1
to Third Parties. 
 2.4 Certain Terms. For purposes of clarity, the rights granted under this Article 2 do not include the right to individually
transfer the GS System (e.g., GS Standard Vectors, Host Cell Lines and/or any GS Updates), Customer Modifications and Formulation Know-Flow (except as provided in Section 3.4.2(c)) to a Sublicensee or a Third Party Contractor. Notwithstanding
the foregoing. Customer Cell Line (including without limitation Customer Cell Lines encompassing one or more of GS Standard Vectors, Customer Modifications and/or Host Cell Lines) may be transferred to Sublicensees and Third Party Contractors under
this Article 2. 
 2.5 Third Party Licenses to the GS System, PFM System, Transfection Medium System and/or Model Vector [####]. With respect to any
product acquired by Licensee from a Third Party (whether by in-license, purchase, or other form of acquisition), to the extent such product was researched, developed or commercialized by such Third Party under
a license from Lonza io the GS System, PFM System. Transfection Medium System and/or Model Vector [####] (a “Third Party-Lonza Agreement”), such product shall be governed by the terms of such Third Party-Lonza Agreement in relation
to its financial terms, but shall otherwise be governed by the terms of this Agreement. For clarity, as used in the preceding sentence, financial terms means those amounts specified as being due upon the achievement of a milestone and/or sale of a
product, including any milestone or royalty term applicable thereto; all other financial terms pertaining thereto (including those set forth in Section 1.45, 1.53 and Sections 4.7.6 through 4.7.11 of this Agreement) shall be governed by the
terms of this Agreement. Notwithstanding the foregoing, relation to the products known as [####], the development, manufacture and sale of such products by Licensee (but not by [####], as the case may be), shall be governed by the terms of this
Agreement. 

  
 66 

 For the avoidance of doubt, if Licensee acquired from a Third Party (a) worldwide rights to develop and
commercialize such product, the terms of this Agreement (and not the Third Party- Lonza Agreement) shall apply worldwide with respect to such product; (b) rights to a specific territory to develop and commercialize such product, but such rights
also include worldwide rights to manufacture such product, the terms of (his Agreement (and not the Third Party-Lonza Agreement) shall apply worldwide with respect to such product, and (c) rights to a specific territory only, the terms of this
Agreement (and not the Third Party-Lonza Agreement) shall apply only to such territory with respect to such product. In addition, in no event shall Lonza be entitled to simultaneously collect a payment for a particular product achieving a particular
activity under a Third Party-Lonza Agreement for which Lonza is er t tied to collect a payment for the same product achieving the same activity under this Agreement. Finally, to the extent there is a conflict between the terms of this Agreement and
such Third Party-Lonza Agreement with respect to a product and territory the terms of this Agreement shall prevail 
 ARTICLE 3. 

TECHNOLOGY TRANSFER 
 3.1 Technology
Transfer. It is understood and agreed by the Parties, that Lonza transferred the GS System, PFM System, Transfection Medium System and Model Vector [####] either to Genentech under the License and Option Agreement, or to Roche under the Umbrella
Research and License Agreement, prior to the Effective Date. Subject to Article 5, it is further understood and agreed that such GS System, PFM System, Transfection Medium System and Model Vector [####] shall be deemed Confidential Information of
Lonza as of the effective date of such transfer. 
 3.2 Additional Technology Transfers (Updates). Following the initial transfer, Lonza shall
provide written notice to Licensee if and when any GS Update or PFM Update becomes available. At Licensee’s written request, Lonza shall provide, at Lonza’s expense, copies of such GS Update or PFM Update, as specified in such written
request, to Licensee. 
 3.3 Form and Control of Transfers. All transfers by Lonza to Licensee hereunder shall be made in a format proposed by Lonza
and reasonably acceptable to Licensee and only to those persons designated in writing by Licensee as authorized to receive such material’s. As of the Effective Date, such authorized persons are: 

(a) for Genentech [####], 

(b) for Roche: [####] 
 3.4 Licensee Rights of
Use. With respect to the GS System, PFM System and Transfection Medium System provided by Lonza to Licensee in accordance with this Article 3 (collectively, the “Materials”), and always subject to Section 2.2 above, the
following shall apply: 

  
 67 

 3.4.1 GS System. 

(a) it is understood and agreed that Licensee shall have the right to make and lest modifications to the GS Standard Vectors, Host Cell Lines
and GS Updates thereto, including but not limited to, changing promoters and/or enhancers, using different iniron sequences and/or modifying untranslated regions of the vectors; 

(b) GS Standard Vectors, Customer Modifications and the Host Cell Lines may not be individually transferred to Third Parties; 

(c) Under the Research License, Customer Cell Lines may be transferred to (i) Sublicensees solely to manufacture, use and import
products and processes that are being researched or developed (including without limitation pre-clinical research and development of Licensed Products) by Licensee (including research or development by a Third
Party Collaborator with, or on behalf of Licensee); and (ii) Third Party Contractors solely to conduct research, development or manufacture (for research or development) of such products and processes (including without limitation pre-clinical research, development and manufacture of such GS Products) on behalf of Licensee or a Third Party Collaborator, 

(d) Under the Multi-Product Commercial License, Customer Cell Lines may be transferred to (i) Third Party Collaborators with respect
to Licensed Products that are being researched, developed and/or commercialized by such Third Party Collaborator with, or on behalf of, Licensee; and (ii) Third Party Licensees with respect to Licensed Products that are being researched,
developed and commercialized by such Third Party Licensee; and (iii) Third Party Contractors solely to conduct research, development and/or manufacture with respect to a Licensed Product on behalf of Licensee, a Third Party Collaborator or a
Third Party Licensee; 
 3.4.2 PFM System. 

(a) Under the Research License, the PFM System may be transferred io Third Party Contractors solely to conduct research, development and
manufacture of products and processes (including without limitation pre-clinical research, development and manufacture (for research or development) of PFM Products) on behalf of Licensee, its Affiliate or
their respective Third Party Collaborator or Third Party Licensee; and. 
 (b) Under the Multi-Product Commercial License, the PFM System may
be transferred to (i) Third Party Collaborators with respect to PFM Products that are being researched, developed and/or commercialized by such Third Party Collaborator with, or on behalf of, Licensee; (ii) Third Party Licensees with
respect to PFM Products that are being researched, developed and/or commercialized by such Third Party Licensee; and (iii) Third Party Contractors solely to conduct research, development and/or manufacture with respect to a PFM Product on
behalf of Licensee, its Affiliate or their respective Third Party Collaborator or Third Party Licensee 
 (c) Notwithstanding
Section 3.4.2(a) and (b), Licensee, shall not disclose the Formulation Know-How (as part of the PFM System) in ns entirety io Sublicensees. On certain occasions, however, a Sublicense will require access
to elements of the Formulation Know-How for specific purposes by way of illustration a Sublicensee may require details of the actual components within the Formulation
Know-How, but not the concentrations of those components, 

  
 68 

 for the preparation of a regulatory filing, or may require details of the method of applying the Formulation
Know How, but not each individual element and/or their concentrations, for technical development purposes In such individual cases as and when the need arises, and only upon the Sublicensee’s written request specifically identifying the person
or persons to whom such disclosure is to be made, Licensee shall have the right to provide such persons, and only to such persons, such elements of the Formulation Know-How as are required to meet the
particular need identified hi such request 
 (d) For the avoidance of doubt, the license gram in use the Formulation Know-How (as part
of the PFM System) shall not prevent Licensee from conducting us own research and development into media and feeds generally. In addition, since the Formulation Know-How relates to the overall composition of
the Protein-Free Feeds and Protein-Free Media rather that the identification of individual ingredients Licensee are not prevented from using certain ingredients, simply because those ingredients are contained in .my list of ingredients contained
with n (he Formulation Know-How Licensee has no obligation to disclose their own proprietary feeds or components thereof to Lonza Licensee shall provide details of any occasion where an element of the
Formulation Know-How has been disclosed to a Sublicensee 
 3.4.3 Transfection Medium System.

 (a) Under the Research License the Transfection Medium System may be transferred to (i) Sublicensees solely to manufacture, use and
import products and processes that are being researched or developed (including without limitation pre-clinical research and development of Licensed Products) by Licensee (including research or development by
a Third Party Collaborator with, or on behalf of, Licensee), and (ii) Third Party Contractors solely to conduct research, development or manufacture (for research or development) of such products and processes (including without limitation pre-clinical research, development and manufacture of such Licensed Products) on behalf of Licensee or a Third Party Collaborator; and 

(b) Under the Multi-Product Commercial License, the Transfection Medium System may be transferred to (i) Third Party Collaborators
with respect to Licensed Products that are being researched, developed and/or commercialized by such Third Party Collaborator with, or on behalf of, Licensee; (ii) Third Party Licensees with respect to Licensed Products that are being
researched, developed and/or commercialized by such Third Party Licensee; and (iii) Third Party Contractors solely to conduct research, development and/or manufacture with respect to a Licensed Product on behalf of Licensee, its Affiliate or
their respective Third Party Collaborator or Third Party Licensee. 
 3.5 Lonza Retained Rights. Subject to the foregoing, all such Materials
delivered by Lonza to Licensee under this Agreement (a) shall remain the sole property of Lonza; (b) shall be used by Licensee only in accordance with the terms and conditions of this Agreement; (c) shall not be used or delivered by
Licensee to or for the benefit of any Third Party except as expressly provided for herein, and (d) shall be used by Licensee in compliance with all applicable laws, rules and regulations 

  
 69 

 3.6 Reports to Lonza. Commencing upon the Effective Date [####], Licensee shall provide Lonza,
[####], an annual written report summarizing any Customer (Modifications conceived and reduced to practice by Licensee in the preceding year during the Agreement, which Licensee determines using its reasonable diligence and judgment,
(a) materially incorporates any GS Know-How (which GS Know-How was Confidential Information of Loma at the time of such reduction to practice) and/or (b) are
claimed in or infringe a Valid Claim of a Patent within the GS Patents. To the extent no such Customer Modifications are made during a particular calendar year, Licensee shall have no obligation to provide a report to Lonza thereto. Any such reports
shall be sent to the attention of the Head of Licensing (as of the Effective Date, [####]) at Lonza. 
 3.7 Lonza Access to Customer Modifications. At
Lonza’s written request at any time during the Term, Lonza shall have the right to discuss in good faith with Licensee the terms under which Licensee may grant Lonza the right to obtain access to such Customer Modifications disclosed to Lonza
under Section 3.6. 
 ARTICLE 4. 

CONSIDERATION 
 4.1 [####]. 

4.2 Initial License Fee. In consideration of the rights granted by Lonza to Licensee under Article 2 and (he technology transferred by Lonza to Licensee
under Article 3, Licensee shall pay to Lonza [####]Licensee shall pay Lonza the respective accrued and payable event payment within thirty (30) days of receipt of an invoice from Lonza with respect thereto. 

4.3 GS Products Event Payments under the Multi-Product Commercial License. 

4.3.1 Event Payments. Subject to Sections 4.3.2 through 4.3.5, Licensee shall pay to Lonza with respect to each GS Product the following
one tune amounts following the first achievement of the following events for such GS Product. 
  

			
	 Event
	  	 Payment

		
	[####]	  	[####]
		
	[####]	  	[####]
		
	[####]	  	[####]
		
	[####]	  	[####]
		
	[####]	  	[####]

 4.3.2 GS Products Subject To Event Payments. It is understood and agreed that, unless otherwise stated
only the following GS Products shall be subject to the event payments under Section 4.3.1: 
 (a) [####] or 

(b) [####]. 

  
 70 

 4.3.3 Multiple GS Products; Multiple Indications for a GS Product. It is understood
and agreed that the payments under Section 4.3.1 shall be due separately for each event bearing GS Product to meet each such specific event; accordingly, if a second or subsequent event bearing GS Product is developed, a further full sec of
event payments will become due and payable at the time(s) set forth in Section 4.3.1 for such second or subsequent event bearing GS Product to meet each such specific event. It is also understood, however, that once a particular event payment
under Section 4.3.1 has been paid with respect io a particular GS Product, that event payment will not be due again with respect to the same GS Product achieving the same event. [####] 

4.3.4 Credit for Discontinued GS Products. If Licensee (or its designee) ceases clinical development of a particular GS Product prior to
the first approval of an MAA for such GS Product (the “Discontinued GS Product”) after having made the payments due under Section 4.3.1(a) above [####]. As used herein, “Back-up
GS Product” means a GS Product that binds (o the same target and has or produces a therapeutic effect similar to such Discontinued GS Product. 

4.3.5 Notice of Achievement; Timing of Payments. With respect to each event referred to in Section 4.3.1, Licensee (or its
Sublicensee) shall promptly inform Lonza following (he achievement of such event. Licensee shall pay Lonza the respective accrued and payable event payment within thirty (30) days of receipt of an invoice from Lonza with respect thereto. 

4.4 PFM Product Events Payments under the Multi-Product Commercial License. 

4.4.1 Event Payments. Subject to Sections 4.4.2 through 4.4.6, Licensee shall pay to Lonza the following [####]: 

 

			
	 Event
	  	 Payment

		
	[####]	  	[####]
		
	[####]	  	[####]
		
	[####]	  	[####]
		
	[####]	  	[####]
		
	[####]	  	[####]

 4.4.2 PFM Products Subject To Event Payments. It is understood and agreed that only [####].
Notwithstanding the foregoing, to the extent such PFM Product is a Formulation Product for which payments were made under Section 4.5, such PFM Product shall not be subject to an event payment under Section 4.4.1. 

In addition, only those quantities of an event bearing PFM Product (i.e., the PFM Patent Product or PFM Know-How
Product) forecasted to be manufactured within the first calendar year following such First Commercial Sale shall be used for determining how much of such PFM Product Lonza was contractually obligated to manufacture at the time of such First
Commercial Sale Licensee shall provide written notice to Lonza no later than the First Commercial Sale of each such milestone bearing PFM Product. 

  
 71 

 4.4.3 PFM Products vs. GS Products. For the avoidance of doubt it is understood and
agreed that to the extent a PFM Product is also a GS Product, such product may be subject to the event payments set forth in Sections 4.2 and 4.3 and this Section 4.4 and the royalty payments set forth in Section 4.7. 

4.4.4 Notice of Achievement; Timing of Payments. With respect to each event referred to in Section 4.4.1, Licensee (or its
Sublicensee) shall promptly inform Lonza following the achievement of such event. Licensee shall pay Lonza the respective accrued and payable event payment [####]with respect thereto. 

4.5 Formulation Products Event Payments under the Multi-Product Commercial License. 

4.5.1 Event Payments. Subject to Sections 4.5.2 through 4.5.5, Licensee shall pay to Lonza the following [####]. 

 

			
	 Clinical Event
	  	 Payment for 1st

Formulation Product

		
	[####]	  	[####]
		
	[####]	  	[####]
		
	[####]	  	[####]
		
	[####]	  	[####]
		
	[####]	  	[####]

 4.5.2 Formulation Products Subject To Event Payments. Subject to Section 4.5.4, it is understood
and agreed that since different quantitative compositions of the Formulation Know-How can be used (a) only the first two (2) Formulation Products made using the same quantitative composition of the Formulation Know-How shall be subject to an event payment under Section 4.5.1, and (b) any subsequent Formulation Product made using the same particular quantitative composition of the Formulation Know-How shall not be subject to an event payment under Section 4.5.1. [####] 
 4.5.3 Multiple
Indications for a Formulation Product. It is understood and agreed that once a particular event payment under this Section 4.5.1 has been paid with respect to a particular Formulation Product, that event payment will not be due again with
respect to the same Formulation Product achieving the some event. [####]. 
 4.5.4 Credit for Discontinued Formulation Products. If
Licensee (or its designee) ceases clinical development of a particular Formulation Product (the “Discontinued Formulation Product”) after having made the payments due under Section 4.5.1 above, then there shall be no payment
due upon the accomplishment of that same event with respect to any Back-up Formulation Product to achieve such event As used herein. “Back-up Formulation
Product” means a Formulation Product that binds to the same target and has or produces a therapeutic effect similar to such Discontinued Formulation Product 

  
 72 

 4.5.5 Notice of Achievement; Timing of Payments. With respect to each event referred
to in Section 4.5.1, Licensee (or us Sublicensee) shall promptly inform Lonza following the achievement of such event. Licensee shall pay Lonza the respective accrued and payable event payment [####]with respect thereto. 

4.6 Event Payment Terms. Roche’s obligation to make event payments for Licensed Products under Section 4.2, 4.3, 4.4 and 4.5 shall expire
[####]. Upon expiration of its payment obligation hereunder with respect to a Licensed Product in a country, the licenses in Article 2 shall be fully paid-up in respect of that Licensed Product in that country
with respect to such milestone payments 
 4.7 Royalties. 

4.7.1 [####]Royalties on . Subject to Section 4.7.4 through 4.7.7, [####], Licensee will [####] 

(a) [####]is Covered by a Valid Claim of any Patents within the GS Patents Controlled by Lonza 

[####], 
 [####]. 

(b) If the [####]: 
 (i) [####],
or 
 (ii) [####]. 
 Licensee shall [####]in
which such sale will be made, 
 For clarity, in the case of a GS Product for which a Valid Claim expires [####], and if Licensee has [####]. 

4.7.2 Royalties on [####]. With respect to [####]. 

4.7.3 Royalties on [####]. Subject to Section 4.7.5 through 4.7.7, on a [####] 

4.7.4 Single Royalty. With respect to [####]. 

4.7.5 Royalty Term. 
 (a)
[####]. The royalty obligations set forth in Section 4.7.1 above will [####], 
 (b) [####]. The royalty obligations set forth in
Section 4.7.3 above will [####]. 

  
 73 

 4.7.6 Rights Following Expiration of Royalty Term [####]. Upon expiration of its
payment obligation hereunder [####]. 
 4.7.7 Timing of Royalty Payment; Payments; Reports. 

(a) For clarity, for purposes of determining when a sale of a Licensed Product occurs, the sale shall be deemed to occur on the date of the
invoice issued by Licensee (or its Sublicensee, as applicable) to the purchaser of the Licensed Product 
 (b) To the extent Licensee
has elected [####] in which the sale was made. 
 (c) To the extent Licensee has elected [####]. Concurrent with such payment, Licensee shall
provide Lonza with a report setting forth 
 (i) [####]; 

(ii) [####]. 
 (iii) the
exchange rate used to convert [####]from [####]to British Pounds; and 
 (iv) the [####]. 

If Licensee is reporting Net Sales for more than one Licensed Product, the foregoing information shall be reported on a Licensed
Product-by-Licensed Product basis. 
 4.8 Payment Method. All payments
hereunder shall be made in British Pounds by bank wire transfer in immediately available funds to the account designated below or such account as Lonza shall designate before such payment is due. If Licensee is required to withhold and remit any tax
to the tax authorities in any regard to any amount payable to the Lonza, such amount shall be withheld and paid to such tax authority. And in case the withholding tax is not deducted from the payment to Lonza and if no further payments are due by
Licensee, Lonza shall promptly reimburse the withholding taxes to Licensee. In such event. Licensee shall notify Lonza and promptly furnish Lonza with copies of any documentation evidencing such withholding. 

Lonza’s Designated Bank: 
  

			
	Name.	  	UBS AG
	Address:	  	CH-8098 Zurich
		
	BIC (SWIFT):	  	[####]
	IBAN:	  	[####]

  
 74 

 4.9 Currency Conversion. For sales of any royalty [####], Net Sales shall first be determined in the
[####]in British Pounds. As of the Effective Date, such currency conversion shall be based on year to date average rate as reported by Reuters. If at any time legal restrictions prevent the prompt remittance of part or all of the royalties with
respect to any country where the Licensed Product is sold, payment shall be made through such lawful means or methods as Licensee reasonably determines to a local bank as designated by Lonza. 

4.10 Taxes. Lonza shall pay all sales, turnover, income, revenue, value added, and other taxes levied on any payments accruing or made to Lonza under
this Agreement, if provision is made in law or regulation of any country for withholding of taxes of any type, levies or other charges with respect to any royalty or other amounts payable under this Agreement to Lonza, then Licensee shall promptly
pay such tax, levy or charge for and on behalf of Lonza to the proper governmental authority, and shall promptly furnish Lonza with receipt of payment. Licensee shall be entitled to deduct any such tax, levy or charge actually paid from royalty or
other payment due to Lonza or be promptly reimbursed by Lonza if no further payments are due to Lonza. Each Party agrees to reasonably assist the other Party in claiming exemption from such deductions or withholdings under double taxation or similar
agreement or treaty from lime to lime in force and in minimizing the amount required to be so withheld or deducted. 
 4.11 Records; Inspection.
Licensee agrees to keep, [####], records of all sales of royalty bearing Licensed Products in sufficient detail, including reports received from its Sublicensees hereunder, to permit Lonza to confirm the accuracy of Licensee’s royally
calculations. Once a year, at the request and expense of Lonza, upon at least [####]prior written notice, and during business hours and at such time as is reasonably acceptable io Licensee. Licensee shall permit a nationally recognized, independent,
certified public accountant appointed by Lonza and acceptable to Licensee, to examine these records solely to the extent necessary to verify such calculations, provided that such accountant has entered into a confidentiality agreement with Licensee
substantially similar to (he confidentiality provisions typically entered into with its own accountants, limiting the use and disclosure of such information to purposes germane hereto. Audits shall be limited to results of the same subject matter in
the [####]prior to such notification that have not been previously audited by Lonza. Results of any such examination shall be made available first to Licensee, and, following redaction of any proprietary information of Licensee not germane to the
calculation of royalties hereunder, then to Lonza. If such examination reveals an underpayment of royalties [####]. Licensee shall pay all costs of such examination. In the event such accountant concludes that additional royalties were owed,
Licensee shall [####] to have such conclusions reviewed by its own accountants, and if they concur, the additional royalties shall be paid within [####]of the date of such concurrence, in this event that Licensee’s accountants do not concur
with the conclusions of the accountants retained by Lonza, the Parties agree to negotiate in good faith to resolve such disagreement as soon as reasonable. In the event that there was an overpayment by Licensee hereunder, Lonza shall promptly (but
in no event later than [####]after Lonza’s receipt of the independent auditor’s report so correctly concluding) refund to Licensee the excess amount. 

  
 75 

 ARTICLE 5. 

CONFIDENTIALITY 
 5.1 Confidentiality
Obligations. During the Term, and [####], the receiving Party shall keep confidential and shall not publish or otherwise disclose or use for any purpose other than as expressly permitted under this Agreement any Confidential Information of the
disclosing Party, except on a need-to know basis to the receiving Party’s directors, officers, employees, agents, consultants, subcontractors, attorneys and accountants, and in addition, with respect to
Licensee to its collaborators, licensees and others on a need to know basis, in each case, to the extent such disclosure is reasonably necessary in connection with the receiving Party’s activities or exercise of rights under this Agreement. To
the extent that disclosure to any person other than a regulatory authority or other governmental body or entity is authorized by this Agreement, prior to disclosure, a Party shall obtain written agreement of such person to hold in confidence and not
disclose or use the Confidential Information of the disclosing Party, which agreement shall contain obligations of confidentiality and non-use no less restrictive than those set forth in this Article 5. The
receiving Party shall notify the disclosing Party promptly upon discovery of any unauthorized use or disclosure of the disclosing Party’s Confidential Information. 

5.2 Exclusions. Notwithstanding anything set forth in this Article 5 to the contrary, the obligations of Section 5.1 shall not apply to the extent
that the Confidential Information of the other Party (as determined by competent documentation) 
 (a) was known or used by the receiving
Party prior to its date of receipt by the receiving Party or 
 (b) either before or after the date of the disclosure to the receiving
Party is lawfully disclosed to the receiving Party by independent sources rightfully in possession of such information, or 
 (c) either
before or after the date of the disclosure to the receiving Party becomes published or generally known to the public through no fault or omission on the part of the receiving Party or its Sublicensees; or 

(d) is independently developed by or for the receiving Party without reference to or reliance upon the Confidential information. 

5.3 Authorized Disclosure. The confidentiality obligations under this Article 5 shall not apply to the extent that a Party is required to disclose
information by applicable law, regulation or order of a governmental agency or a court of competent jurisdiction; provided, however, that such Party shall (to the extent permitted by law) provide written notice thereof to the other Party, consult
with the other Party with respect to such disclosure and provide the other Party a reasonable opportunity to object to any such disclosure or to request confidential treatment thereof. 

5.4 Terms of Agreement. The Parties agree that this Agreement and the terms hereof will be considered Confidential Information of both Parties. 

5.5 No License. As between the Parties, Confidential Information disclosed hereunder shall remain Che property of the disclosing Party. Disclosure of
Confidential Information to the other Party shall not constitute any grant, option or license to the other Party, beyond those licenses and options expressly granted under Article 2, under any patent, trade secret or other rights now or hereinafter
held by the disclosing Party. 

  
 76 

 ARTICLE 6. 

PUBLICITY AND PUBLICATIONS 
 6.1
Publicity. If a Party desires to issue a press release or other public statement or announcement concerning this Agreement, the subject matter hereof, or the research, development or commercial results of the products hereunder, it must first
obtain the other Party’s written approval of the proposed release or announcement; provided that such approval shall not be unreasonably withheld if required pursuant to the disclosure requirements of the Securities and Exchange Commission
(“SEC”) or the national securities exchange or other stock market on which such Party’s securities are traded (“Exchange”). All press releases and other publicity will conform to the publicity strategy and
policy developed by the Parties Without limiting the generality of the foregoing, each Party agrees that the other Party will have no less than [####] review and provide comment regarding any such proposed press release or publicity, unless a
shorter review time is agreed to by both Parties or required by law or rules, of such an Exchange. In the event that one Party reasonably concludes that a given disclosure is required by law and the other Party would prefer not to make such
disclosure, then the Party seeking such disclosure shall either (i) limit said disclosure to address the concerns of the other Party, or (ii) provide a written opinion from counsel staling that such disclosure is required by law. With
respect to complying with the disclosure requirements of the SEC in connection with any required SEC filing of this Agreement, the filing Party shall seek confidential treatment of portions of this Agreement from the SEC and shall provide the other
Party with the opportunity, for least fifteen (15) days, to review any such proposed filing Each Party agrees that it will obtain its own legal advice with regard to its compliance with securities laws and regulations, and will not rely on any
statements made by the other Party relating to such securities laws and regulations. 
 6.2 Publication. Notwithstanding Section 6.1, both
Parties recognize that the publication or disclosure of papers, presentations, abstracts or any other written or oral presentations regarding results of and other information regarding research and development activities conducted using the GS
System. PFM System and for Transfection Medium System may be beneficial to both Parties, provided that such publications or presentations are subject to reasonable controls to protect Confidential Information and the patentability of
inventions. Accordingly, the following shall apply with respect to papers and presentations proposed for disclosure by either Party. 
 (a)
with respect to any paper or presentation proposed for disclosure by Licensee which utilizes information generated from the use of the GS System. PFM System and/or Transfection Medium System (including without limitation any Customer Cell Lines,
Customer Modifications, GS Products or PFM Products), so long as such paper or presentation does not include any Confidential Information of Lonza. Licensee shall be free to make, publish and disclose such papers and presentations at its discretion
so long as Licensee provides written notice to Lonza of such publication at least [####]prior to the date of such proposed publication, 

(b) with respect to any paper or presentation proposed for disclosure by Lonza which utilizes information generated by Lonza from the use
of the GS System, PFM System and/or Transfection Medium System, so long as such paper or presentation does not include any Confidential Information of Licensee (including without limitation any Customer Cell Lines, Customer Modifications, GS
Products or PFM Products). Lonza shall be free to make, publish and disclose such papers and presentations at its discretion; 

  
 77 

 (c) with respect to all other publications utilizing information generated from the use
of the GS System, PFM System and/or Transfection Medium System, including without limitation any publications containing Confidential information of the ocher Party, each Party shall have the right to review and approve any such paper or
presentation proposed for disclosure by the other Party Before any such paper or presentation is disclosed, the Party proposing disclosure shall deliver a complete copy to the other Party at least [####]prior to submitting the paper to a publisher
or making the presentation to a Third Party. The other Party shall review any such paper or presentation and shall inform the submitting Party with in [####] of its receipt of such paper or presentation if the proposed disclosure contains any
Confidential Information of the other Party or any patentable subject matter. The submitting Party shall comply with any request to delete references to Confidential Information of the other Party in any such paper or presentation, and, if so
requested by the other Party, shall delay such proposed disclosure for a period of [####]or such longer period of lime as is reasonable to permit the timely preparation of a patent application by the other Party. 

ARTICLE 7. 
 INTELLECTUAL
PROPERTY 
 7.1 Ownership of Inventions and Know-How. Ownership of all inventions and Know-How conceived or made in the course of activities performed under this Agreement shall be determined in accordance with the laws of inventorship of the United States. Subject to the foregoing, and the licenses
granted to Licensee in Article 2, such inventions and Know-How that are conceived or made (i) solely by employees of a Party shall, as between the Parties, be solely owned by such Party, and
(ii) jointly by employees of Licensee and employees of Lonza will be owned jointly by Licensee and Lonza (“Joint Inventions”). 
 7.2
Disclosure. Each Party shall promptly disclose to the other any invention disclosure submitted in the normal course of business which disclose a Joint Invention [####]after the Party determines that a Joint Invention has been made. 

7.3 Prosecution of Joint Inventions. In the event of a Joint Invention, the Parties shall discuss and agree upon which Party shall be responsible for
the preparation, filing, prosecution and maintenance of any Patent covering such Joint Invention, 
 7.4 Ownership of Licensee Improvements; Licensee
grant to Lonza. 
 7.4.1 Licensee shall own the Licensee Improvements. However, Licensee may only use the Licensee Improvements for the
purposes of its own and its Affiliates’ internal research and in connection with the development, commercialisation and manufacture of Licensed Products. Licensee or its Affiliates may not licence the Licensee Improvements lo any third party,
except to the extent necessary in connection with the out-licensing of a Licensed Product to a third party. Licensee hereby grants to Lonza a non-exclusive,
royalty-free, worldwide right and license (including the right lo sublicense) under the Licensee Improvements (whether patented or unpatented) in the development, manufacture and sale of products. 

  
 78 

 7.4.2 As used herein, “Licensee Improvements” means any improvement,
enhancement, invention or other modification (other than Customer Modifications) made by Licensee to any dement of the GS System, PFM System or {he Formulation Know How, that materially incorporates GS
Know-How, Protein-Free Know-How or infringes a Valid Claim of a GS Patent or PFM Patent, and which were made and filed for patent protection (if applicable) by Licensee
on or prior to the earlier of the (i) last to expire Valid Claim of a Patent within the GS Patents or PFM Patent (as applicable) or (ii) [####]. For the avoidance of doubt, Licensee must always obtain the prior written consent of Lonza should
Licensee wish to include any Lonza Confidential Information within a patent application. 
 7.4.3 For the avoidance of doubt, any
improvement, enhancement, invention or other modification made by Licensee to any clement of the GS System, PFM System or the Formulation Know-How after expiration of Licensee’s applicable royalty
obligation under Section 4.7 shall not be considered a Licensee Improvement. 
 ARTICLE 8. 

REPRESENTATIONS AND WARRANTIES 
 8.1
Lonza Warranty. 
 8.1.1 As of the Effective Date, Lonza represents and warrants that: (a) it is a corporation duly organized,
validly existing and in good standing under the laws of Switzerland; (b) all necessary consents, approvals and authorizations of all governmental authorities and other persons or entities required to be obtained by Lonza in connection with this
Agreement have been obtained; (c) the execution, delivery and performance of this Agreement have been duly authorized by all necessary corporate action on the part of Lonza; and (d) this Agreement is a legal and valid obligation binding
upon Lonza and enforceable in accordance with its terms. 
 8.1.2 Lonza also represents and warrants that; (a) it is the sole and
exclusive owner or exclusive licensee of all right, title and interest in the GS System, PFM System and/or Transfection Medium System existing prior to and/or as of the Effective Date; (b) it has the right to grant the rights and licenses
granted herein; (c) the GS System. PFM System and/or Transfection Medium System are free and clear of any lien or security interest; (d) as of the Effective Date, the GS Updates and PFM Updates are generally made available by Lonza to its
licensees of the GS System, PPM System and/or Transfection Medium System, as applicable, for no financial consideration, (c) it has not previously granted any right, license or interest in or to the GS System, PFM System and/or Transfection
Medium System, or any portion thereof, inconsistent with the rights and licenses granted to Licensee herein; (f) to its knowledge (without duty of inquiry) as of the Effective Date it has not received notice of any threatened or pending
actions, lawsuits, claims or arbitration proceedings in any way relating to the GS System, PFM System and/or Transfection Medium System, and (g) to its knowledge (without duty of inquiry) as of the Effective Date, no Third Party Patents would
be infringed by the practice of the rights granted under Article 2, including without limitation the manufacture, use, sale, offer for sale or import of (i) any product or process claimed or described in the Patents within the GS Patents and/or
Protein-Free Patents, or (ii) any Licensed Product 

  
 79 

 8.2 Licensee Warranty. As of the Effective Date Licensee represents and warrants that; (a) it is
a corporation duly organized, validly existing and in good standing under the laws of Switzerland, (b) all necessary consents, approvals and authorizations of all governmental authorities and other persons or entities required to be obtained by
Licensee in connection with this Agreement have been obtained; (c) the execution, delivery and performance of this Agreement have been duly authorized by all necessary corporate action on the part of Licensee, and (d) this Agreement is a
legal and valid obligation binding upon Licensee and enforceable in accordance with its terms 
 8.3 Effect of Representations and Warranties. It is
understood that if the representations and warranties made by a Party under this Article 8 are not true and accurate and the other Party incurs damages, liabilities, costs or other expenses as a result, the Party making such representations and
warranties shall indemnify and hold the other Party harmless from and against any such damages liabilities, costs or other expenses incurred as a result, in accordance with the terms of Article 9 below. 

ARTICLE 9. 

INDEMNIFICATION 
 9.1 Indemnification by
Lonza. Subject to Sections 9.3 and 12.8, Lonza shall defend, indemnify and hold harmless each of Licensee and its directors, officers, and employees of Licensee and the successors and assigns of any of the foregoing (each a “Licensee
Indemnitee”) from and against any and all liabilities, damages, settlements, penalties, fines, costs or expenses (including, without limitation, reasonable attorneys’ fees and other expenses of litigation) (collectively,
“Liabilities”) arising, directly or indirectly out of or in connection with Third Party claims, suits, actions, demands or judgments, relating to (a) the activities performed by or on behalf of Lonza under Article 3, (b) breach
of the representations and warranties under Section 8.1, or (c) Lonza gross negligence or willful misconduct, except, in each case, to the extent caused by the gross negligence or willful misconduct of Licensee 

9.2 Indemnification by Licensee. Subject to Sections 9.3 and 12.8, Licensee shall defend, indemnify and hold harmless each of Lonza and its directors,
officers, and employees of Lonza and the successors and assigns of any of the foregoing (each a “Lonza Indemnitee”) from and against any and all Liabilities arising directly or indirectly out of or in connection with Third Party
claims, suits, actions, demands or judgments, relating to (a) the activities performed by or on behalf of Licensee or its Sublicensees hereunder in connection with the exercise of its licenses and rights hereunder, (b) breach of the
representations and warranties under Section 8.2, or (c) Licensee’s gross negligence or willful misconduct, except, in each case, to the extent caused by the gross negligence or willful misconduct of Lonza. 

9.3 Procedure. If a Lonza Indemnitee or Licensee Indemnitee (the “Indemnitee”) intends to claim indemnification under this Article 9,
it shall promptly notify the other Party (the “Indemnitor”) in writing of such alleged Liability. The Indemnitor shall have the right to control the defense thereof with counsel of its choice as long as such counsel is reasonably
acceptable to Indemnitee; provided, however, that any Indemnitee shall have the right to retain its own counsel at its own expense, for any reason, including if representation of any Indemnitee by the counsel retained by the Indemnitor would be
inappropriate due to actual or potential differing interests 

  
 80 

 between such Indemnitee and any other Party reasonably represented by such counsel in such proceeding The
Indemnitee, its employees and agents, shall reasonably cooperate with the Indemnitor and its legal representatives in the investigation of any Liability covered by this Article 9. The obligations of this Section 9.3 shall not apply to amounts
paid in settlement of any claim, demand, action or other proceeding if such settlement is effected without the consent of the Indemnitor, which consent shall not be withheld or delayed unreasonably The failure to deliver written notice to the
indemnitor within a reasonable time after the commencement of any such action, if prejudicial to its ability to defend such action, shall relieve the Indemnitor of any obligation to the Indemnitee under this Section 9 3. It is understood that
only Lonza or Licensee may claim indemnity under this Article 9 (on its own behalf or on behalf of its Indemnitees), and other Indemnitees may not directly claim indemnity hereunder 

ARTICLE 10. 
 TERM AND
TERMINATION 
 10.1 Term of Agreement. The term of this Agreement (the “Term”) shall commence on the Effective Date, and unless
earlier terminated as provided in this Article 10, shall continue in full force and effect [####], Licensee shall have a non-exclusive, royalty-free, fully-paid up, perpetual, worldwide license, with the right
to grant and authorize sublicenses under the GS System, PFM System and Transfection Medium System. 
 10.2 Termination for Cause. If a Party is in
material breach of this Agreement, the other Party may elect to give the Party in breach written notice describing the alleged breach. If the breaching Party has not cured such breach within [####]after receipt of such notice, the notifying Party
shall be entitled, in addition to any other rights it may have under this Agreement, to terminate this Agreement effective immediately. However, if such Party alleged to be in breach disputes in good faith such breach by written notice lo the other
Party within such [####]period, the matter will be submitted to arbitration as provided in Article II. In such event, such notifying Party shall not have the right to terminate this Agreement until it has been determined in such arbitration
proceeding that the Party alleged to be in breach is in material breach of this Agreement With respect to breaches by Licensee to pay any amounts due and payable by Licensee io Lonza hereunder, the effective date of such termination shall be deemed
to be the date that is [####]after Licensee’s receipt of notice of such breach, and (ii) with respect to all other breaches by either Party, such Party in breach further fails to cure such breach within [####]after the conclusion of such
arbitration proceeding. 
 10.3 Permissive Termination. Licensee shall have the right to terminate this Agreement in ns entirety or on a license by
license basis, in its sole discretion, upon [####]written notice to Lonza. 
 10.4 [####]. 

10.5 Effect of Termination. 
 10.5.1
Accrued Rights and Obligations. Termination of this Agreement for any reason shall rot release either Party hereto from any liability which, at the time of such termination, has already accrued to the other Party or which is attributable to a
period prior to such termination, nor preclude either Party from pursuing any rights and remedies it may have hereunder or at law or in equity which accrued or are based upon any event occurring prior to such termination 

  
 81 

 10.5.2 Return of Confidential Information. Upon any termination of this Agreement,
each Party shall promptly return (or destroy and provide written certification thereof) to the other Party all Confidential Information received from the other Party, including any copies thereof (except one copy of which may be retained for
archival purposes solely to ensure compliance with the terms of this Agreement) 
 10.6 Survival. This Section 10.6 and Articles 1, 5, 6, 7, 8,
9 (with respect to those acts or omissions that occurred prior to the effective date of expiration or termination of this Agreement which gave rise to such indemnification obligations) 11 and 12 of this Agreement shall survive expiration or
termination of this Agreement for any reason. 
 ARTICLE 11. 

DISPUTE RESOLUTION 
 11.1
Exclusions. Section 11.2 below shall not apply to any disputes arising under Article 5 (Confidentiality) and each Party shah be entitled to exercise all available remedies and actions with respect thereto, without any restriction, delay,
condition or waiting period, 
 11.2 Dispute Resolution. 

11.2.1 Disputes. The Parties recognize that a bona fide dispute as to certain matters may from time to time arise during the Term that
relates to a Party’s rights and/or obligations under this Agreement. Unless otherwise specifically recited in this Agreement, disputes among the Parties will be resolved as recited in this Section 11.2. If such a dispute occurs, any Party
may, by written notice to the other Party, have such dispute referred to their respective officers designated below, or their respective designees, for attempted resolution by good faith negotiations within [####] after such notice is received Such
designated officers are as follows: 
 (a) For Licensee—Head of Roche Partnering 

(b) For Lonza—Head of Pharma & Biotech 

If the designated officers, or their respective designees, are not able to resolve, such dispute within such [####]period, or such other period of time as the
Parties may mutually agree in writing, either Party may, by written notice io the other, invoke the following provisions of this Section. 
 11.3
Jurisdiction. This Agreement shall be governed and construed in accordance with the laws of Switzerland, without reference to its conflict of laws principles. The Parties agree that the competent courts of Basel-City, Switzerland, shall have
exclusive jurisdiction to settle any dispute arising out of or in connection with this Agreement (including a dispute regarding the existence, validity or termination of this Agreement). 

  
 82 

 11.4 Determination of Patents and Other Intellectual Property. Notwithstanding the foregoing, any
dispute relating to the determination of validity of a Party’s Patents or other issues relating to a Party’s intellectual property shall be submitted to a court of competent jurisdiction (a) selected by Licensee, in the case of any
such dispute involving any patent or other intellectual property of Licensee, and (b) selected by Lonza, in the case of any such dispute involving any patent or other intellectual property of Lonza. 

11.5 Injunctive Relief. This Article 11 shall not be construed to prohibit either Party from seeking preliminary or permanent injunctive relief,
restraining orders or specific performance from any court of competed jurisdiction to the extent not otherwise expressly prohibited under this Agreement. For the avoidance of doubt, such equitable remedies shall be cumulative and not exclusive and
are in addition to any other remedies which either Party may have under this Agreement or applicable law. 
 ARTICLE 12. 

MISCELLANEOUS 
 12.1 Governing Law.
This Agreement, and any proceeding subject lo Article II, shall be governed by and construed in accordance with the laws of Switzerland, without reference to principles of conflicts of laws. 

12.2 Independent Contractors. Nothing m this Agreement is intended or shall be deemed to constitute a partnership, agency, distributorship,
employer-employee relationship or joint venture relationship between the Parties Each Party hereby expressly disclaims that this Agreement creates any fiduciary relationship between the Parties. No Party shall incur any debts or make any commitments
for the other Party, except to the extent specifically provided herein. 
 12.3 Assignment. This Agreement shall be binding upon the successors and
assigns of the Parties and the name of a Party appearing herein shall be deemed to include the names of its successors and assigns Neither Party may assign its interest under this Agreement without the prior written consent of the other Party;
provided however, either Party may assign its interest under this Agreement without the prior written consent of the other, loan Affiliate, oi to a successor of that Party’s business by reason of merger, sale of all or substantially all of its
assets or other form of acquisition Any purported assignment without a required consent shall be sold. No assignment shall relieve any Party of responsibility for the performance of any obligation that accrued prior to the effective date of such
assignment. 
 12.4 Further Actions. Each Party agrees to execute, acknowledge and deliver such further instruments and to do all such other acts as
may be necessary or appropriate in order to carry out the purposes and intent of this Agreement 
 12.5 Notices and Deliveries. Any notice, requests,
delivery, approval or consent required or permitted to be given under this Agreement shall be in writing and shall be deemed to have been sufficiently given if delivered in person, transmitted by commercial overnight courier, or transmitted by
facsimile to the Party to whom it is directed at the address shown below or at such other address as such Party shall have last given by notice to the other Party: 

 

			
	If to Lonza	  	Lonza Sales AG
		  	Milnchensteinerslrasse 38
		  	CH-4002 Basel
		  	Switzerland
		  	Fax: +[####]
		  	Phone: +[####]

  
 83 

			
		
	with a copy to:	  	Lonza Biologies plc
		  	Head of Legal Services
		  	228 Bath Road
		  	Slough, Berkshire, SLI 4DX, England
		  	Fax:+ [####]
		  	Phone; +[####]
		
	If to :	  	F. Hoffmann-La Roche Ltd
		  	Grenzacherstrasse 124
		  	CH-4070 Basel
		  	Switzerland
		  	Attention: Legal Department
		  	Facsimile [####]
		
		  	Genentech, Inc.
		  	Attn: Vice President, Genentech Partnering
		  	1 DNA Way
		  	South San Francisco, CA 94080
		  	U.S.A.
		  	Fax. [####]

 12.6 Force Majeure. Neither Party shall lose any rights hereunder or be liable to the other Party for damages or
losses (except for payment obligations) on account of failure of performance by the defaulting Party if the failure is occasioned by war, strike, fire, Act of God, earthquake, flood, lockout, embargo, governmental acts or orders or restrictions,
failure of suppliers, prevention from or hindrance in obtaining energy or other utilities, a market shortage of raw materials or necessary components, contamination of Licensee’s (or its Sublicensee’s) facility that was used for the
clinical or commercial manufacture of the GS Product, or any other reason where failure to perform is beyond the reasonable control and not caused by the negligence, intentional conduct or misconduct of the nonperforming Party and such Party has
exerted all reasonable efforts to avoid or remedy such force majeure, provided, however, that in no event shall a Party be required to settle any labor dispute or disturbance. 

12.7 Advice of Counsel. Lonza and Licensee have each consulted counsel of their choice regarding this Agreement, and each acknowledges and agrees that
this Agreement shall not be deemed to have been drafted by one Party or another and will be construed accordingly. 
 12.8 Limitation of Liability.
NEITHER PARTY SHALL BE LIABLE TO THE OTHER PARTY OR ANY THIRD PARTY FOR ANY SPECIAL, CONSEQUENTIAL, EXEMPLARY OR INCIDENTAL DAMAGES (INCLUDING LOST OR ANTICIPATED REVENUES OR PROFITS RELATING TO THE SAME). ARISING FROM ANY CLAIM RELATING TO THIS
AGREEMENT. WHETHER SUCH CLAIM IS BASED ON CONTRACT, TORT (INCLUDING NEGLIGENCE) OR OTHERWISE, EVEN IF AN AUTHORIZED REPRESENTATIVE OF SUCH PARTY IS ADVISED OF THE POSSIBILITY OR LIKELIHOOD OF SAME. 

  
 84 

 12.9 Severability; Waiver. If any one or more of the provisions of this Agreement should for any
reason be held by any court or authority having jurisdiction over this Agreement or either of the Parties to be invalid, illegal or unenforceable, such provision or provisions shall be validly reformed to as nearly as possible approximate the intent
of the Parties and, if unreformable shall be divisible and deleted in such jurisdiction, elsewhere, this Agreement shall not be affected so long as the Parties are still able to realize the principal benefits bargained for in this Agreement. 

12.10 Prior Agreements; Modification. Except with respect to Chugai, this Agreement, together with the Exhibits hereto, supersedes the License and
Option Agreement and Umbrella Research and License Agreement. No waiver, modification or amendment of any provision of this Agreement shall be valid or effective unless made in writing and signed by a duly authorized officer of each of the Parties.

 12.11 Counterparts. This Agreement may be executed in two counterparts, each of which shall be deemed an original and which together shall
constitute one instrument. 
 (the remainder of this page is left intentionally blank) 

  
 85 

 IN WITNESS WHEREOF, Loan and Licensee, intending to be legally bound, have executed this Agreement as
of the Effective Date by their respective duty authorized representatives. 
 LONZA SALES AG 

 

							
	By:	 	  
	    		  	
				
	Name:	 	  
	    		  	
				
	Title:	 	  
	    		  	
	
	F. HOFFMANN-LA ROCHE LTD
				
	By:	 	  
	    	By:	  	  

				
	Name:	 	  
	    	Name:	  	  

				
	Title:	 	  
	    	Title:	  	  

		
	HOFFMANN-LA ROCHE INC.	    	GENENTECH, INC.
				
	By:	 	  
	    	By:	  	  

				
	Name:	 	  
	    	Name:	  	  

				
	Title:	 	  
	    	Title:	  	  

  
 86 

 EXHIBIT 1.28 

[####] 

  
 87 

 Appendix 4.3 

[####] 

  
 88 

 Appendix 6.2 

[####] 

  
 89 

 Amendment No 1 to the License Agreement 

THIS AMENDMENT NO 1, acknowledged and executed as of the last signature (“Amendment Date”), by and between F.
Hoffmann-La Roche Ltd, with an office and place of business at Grenzacherstrasse 124, 4070 Basel, Switzerland ( Roche Basel ) and Hoffmann-La Roche Inc. with an
office and place of business at 150 Clove Road, Suite 8, Little Falls, New Jersey 07424, U.S.A. (“Roche US”; Roche Basel and Roche US together referred to as “Roche”) on the one hand and PEGA-ONE SAS (RCS number 853
093 458 Creteil) with an office and place of business at 1 Mail du Professeur Georges Malthé, Villejuif Bio-Park, 94800 Villejuif, France (“PEGA1”) on the other hand (Roche and PEGA1
collectively referred to as the “Parties”), 
 WHEREAS PEGA 1 and Roche have executed a License Agreement (“Agreement ) on
January 2, 2020 (“Signature Date”), not yet entered into effect, and as rectified by Corrigendum No 1 entered into by PEGA 1 and Roche on March 30, 2020, 

WHEREAS PEGA 1 and Roche wish to clarify certain matters relating to the relationship between F. Hoffmann-La Roche Ltd
and the registered owner of the Roche Patent Rights and Roche Glycoengineering Technology Patent Rights, namely Roche Glycart AG; 
 WHEREAS PEGA1 and Roche
wish to make certain amendments to the Agreement in order to clarify such matters; 
 NOW, THEREFORE, the PEGA 1 and Roche acknowledge and agree as
follows: 
  

	 	1.	 Section 15.3 of the Agreement shall be amended by the addition of the following sentence at the end
of that Section 15.3: 

 “Roche covenants to PEGA 1 that during the Agreement Term and if applicable, it shall
cause Roche Glycart AG, , to do all such acts and enter into all such documents as may in each case be reasonably necessary in order for Roche to carry out its obligations and to provide PEGA 1 with the rights and benefits, under this
Agreement.” 
  

	 	2.	 A new Section 2.2 entitled “Non-exclusive License” shall
be added after Section 2.1: 

 “Upon Pega 1’s request, the Parties shall in good faith negotiate [####] as
existing at that time (“Additional Roche Patent Rights”, provided Pega 1 can reasonably demonstrate that such license grant is required for the development of the Product. For the avoidance of doubt, Roche shall have no obligation
to maintain Additional Roche Patent Rights and Pega 1 will not be granted any rights to any Roche compounds (nor any other intellectual property relating to or covering such compounds) other than GA201.” 

 

	 	3.	 The following shall be added to the table in Section 1.78 of the Agreement: 

 

			
	 Additional Roche Patent Rights
	  	2.2

  
 90 

	 	4.	 Save as set out in this Amendment Agreement, nothing shall vary, or be construed to vary the Agreement. The
terms of the Agreement shall enter into or shall remain in full force and effect as set forth in Section 21.13 of the Agreement. 

[Signature Page Follows] 

 IN WITNESS WHEREOF, the Parties have caused this Amendment No 1 to be executed as of the
Amendment Date by their duly authorized representatives. 
  

	
	PEGA-ONE SAS
	
	 /s/ Denetriaw Kydoniews

	Name: Denetriaw Kydoniews
	Title: Board Member and acting CEO
	Date : March 31, 2020

  

					
	F. Hoffmann-La Roche Ltd	 	    	  	
			
	  
	 		  	  

	Name:	 		  	Name:
	Title:	 		  	Title:
	Date:	 		  	Date:

  

	
	Hoffmann-La Roche Inc.
	
	  

	Name:
	Title:
	Date:

  
 92 

 To: 
 F. Hoffmann-La Roche Ltd, 
 Grenzacherstrasse 124, 

4070 Basel, 
 Switzerland 

Hoffmann-La Roche Inc. 

150 Clove Road, 
 Suite 8, Little Falls, 

New Jersey 07424, 
 U.S.A 

(together referred to as “Roche”) 

12 January 2021 
 Dear [####] 

License Agreement dated 2 January 2020 

Roche and PEGA 1 (collectively referred to as the “Parties”) executed a License Agreement (“Agreement”) on January 2,
2020 which was effective as of April 1, 2020. The Agreement was rectified by Corrigendum No 1 entered into by the Parties on March 30, 2020, and amended by Amendment No 1 entered into by the Parties on April 1, 2020. 

Capitalised terms used in this letter agreement shall have the meaning ascribed to them in the Agreement unless otherwise defined in this letter agreement.

 PEGA 1 and Roche wish to clarify certain matters relating to: (a) the proposed acquisition of [####] ordinary shares of PEGA 1 and [####] series A
ordinary shares of a nominal value of EUR 0.01 by Medicxi (MG1) S.à.r.l. (“Medicxi”) from Pegascy and FPCI Biodiscovery 5; (b) the proposed acquisition of the entire issued share capital of PEGA 1 by United Medicines
Biopharma Limited (“UMED”) by way of a share for share exchange (“UMED Acquisition”); (c) the proposed acquisition of the entire issued share capital of PEGA 1 by United Medicines Biopharma (Midco) Limited (a wholly
owned subsidiary of UMED) (“Midco”); (d) the subsequent fundraising by UMED; and (e) the initial public offering by UMED (together the “Proposed UM Transactions”). 

On 31 December 2020, PEGA 1 notified Roche of the Proposed UM Transactions and provided Roche with a Review Notice (“ROFN Notice”). 

  
 1 

 The Parties agree that: 
  

	1.	 the Proposed UM Transactions shall be treated as a Change of Control, and accordingly shall together constitute
a single Strategic Transaction; 

  

	2.	 Roche hereby confirms that it is not exercising its Right of First Negotiation set out in Section 3 of the
Agreement with respect to the Proposed UM Transactions and responds to the ROFN Notice as such; 

  

	3.	 Notwithstanding paragraph 2 above, Roche’s rights in respect of the Right of First Negotiation in
Section 3 of the Agreement shall continue to apply for the period commencing on the completion of the UMED Acquisition, and shall cease to apply on the earlier of (i) the third anniversary of the UMED Acquisition and (ii) the first
Change of Control following the Proposed UMED Transactions; 

  

	4.	 in consideration for Roche agreeing the matters set out in paragraphs 1 to 3 above and acknowledging the
Proposed UM Transactions, PEGA 1 shall procure that UMED issues Roche ordinary shares in UMED worth EUR [####] (i.e. such number of shares having a value equal to [####] of the net asset value attributed to PEGA 1 in accordance with the UMED
Acquisition) (the “Roche Shares”) ; 

  

	5.	 following the issue of the Roche Shares by UMED, Roche shall be due no further Strategic Transaction payments
in relation to the Proposed UM Transactions; and 

  

	6.	 following completion of the UMED Acquisition, all amounts of funding received by PEGA 1 from UMED and/or any of
its subsidiary undertakings, shall constitute Private Financings for the purposes of the Agreement. 

 The Parties agree that the
Agreement shall be construed subject to and in accordance with this letter agreement, but that save as set out in this letter agreement, nothing shall vary, or be construed to vary the Agreement. 

The Parties agree that the existence and the contents of this letter and any communications or information relating to the same that have been, or after the
date of this letter are, shared between the parties shall each be treated as confidential and as “Confidential Information” as defined in the Agreement. 

This letter and the documents referred to or incorporated in it constitute the entire agreement between the parties relating to the subject matter of this
letter agreement and supersede and extinguish any prior drafts, agreements, undertakings, representations, warranties and arrangements of any nature whatsoever, whether or not in writing, between the parties in relation to the subject matter of this
letter. 
 This letter agreement may be executed in any number of counterparts, each of which shall constitute an original, and all the counterparts shall
together constitute one and the same agreement. The exchange of a fully executed version of this letter agreement (in counterparts or otherwise) by electronic transmission in PDF format or otherwise shall be sufficient to bind the parties to the
terms and conditions of this letter agreement and no exchange of originals is necessary. 
 This letter agreement does not confer any rights on any person
or party other than the parties to this letter agreement and any successors-in-interest thereto. 

  
 2 

 Yours faithfully 

/s/ Demetrios Kydonieus 
 Signed by Demetrios Kydonieus on
behalf of PEGA-ONE SAS 

  
 3 

					
	We agree the above:	 	    	  	
			
	Signature: /s/ Joerg Kazenwadel	 		  	/s/ Felix Kobel
	on behalf F. Hoffmann-La Roche Ltd	 		  	
	Name of signatory: Joerg Kazenwadel	 		  	Felix Kobel
	Title: Head of R&D Out-Licensing	 		  	Senior Legal Counsel
	Date: 12 January 2021	 		  	

  

	
	Signature: /s/ Gerald Bohn on behalf Hoffmann-La Roche Inc.
	Name of signatory: Gerald Bohn
	Title: Assistant Secretary
	Date: 12 January 2021

  
 4 

 Amendment No 2 to the License Agreement 

THIS AMENDMENT NO 2, acknowledged and executed as of the last signature (“Amendment Date”), by and between F.
Hoffmann-La Roche Ltd, with an office and place of business at Grenzacherstrasse 124, 4070 Basel, Switzerland (“Roche Basel”) and Hoffmann-La Roche Inc.
with an office and place of business at 150 Clove Road, Suite 8, Little Falls, New Jersey 07424, U.S.A. (“Roche US”; Roche Basel and Roche US together referred to as “Roche”) on the one hand and PEGA-ONE SAS (RCS
number 853 093 458 Creteil) with an office and place of business at 1 Mail du Professeur Georges Malthé, Villejuif Bio-Park, 94800 Villejuif, France (“PEGA 1”) on the other hand (Roche
and PEGA1 collectively referred to as the “Parties”). 
 WHEREAS PEGA 1 and Roche have executed a license agreement on January 2, 2020

 (“Signature Date”), as rectified by Corrigendum No 1 of March 30, 2020 and subsequently amended by AMENDMENT NO 1 entered into by
PEGA1 and Roche on April 1, 2020 (all together referred to as the “Agreement”), granting PEGA 1 certain rights to the compound GA201 (“Compound”). 

WHEREAS Roche has entered into a license agreement with NantKwest, Inc. (formerly Conkwest, Inc.) (“NantKwest Agreement”) on November 1,
2010, granting Roche certain rights to use the NK92 cell line (“NK92 Cell Line”), and Roche has developed a cell-based potency assay for Compound (“Assay”) based on NK92 Cell Line. 

WHEREAS PEGA 1 and Roche wish to grant to PEGA1 a sublicense under the NantKwest Agreement. 

NOW, THEREFORE, PEGA 1 and Roche acknowledge and agree as follows: 
  

	 	1.	 A new Section 2.2.a entitled “Non-exclusive NantKwest
Sublicense” shall be added after Section 2.2: “Roche hereby grants to PEGA1 a non-exclusive sublicense under the NantKwest Agreement (a copy of which, with reasonable redactions, is herewith
attached to the Agreement as Appendix 2.2.a) solely for the purpose of allowing PEGA1 to perform Assay as a release assay for Compound, and solely as required to perform PEGA1 ‘s rights under Agreement. 

The sublicense granted under this Section 2.2 shall be subject to the rights and obligations and undertakings of Roche, as applicable and
consistent with the NantKWest Agreement. Roche shall act as the sole direct contact with NantKwest, Inc. in relation to the sub-license under this Section 2.2.a. 

PEGA1 shall comply with the terms of the NantKWest Agreement to the extent such terms are disclosed in the respective Appendix attached
hereto. 
 Roche shall not amend the NantKWest Agreement in a manner that affects any such
sub-licenses hereunder, shall use commercially reasonable efforts to enforce and maintain such agreements with respect to the Compound and/or the Product, and shall promptly notify PEGA1 in writing of any
threatened or actual termination or 

 
notice regarding same with respect to such NantKWest Agreement with respect to the Compound and/or the Product. Roche shall provide copies (with reasonable redactions) of any amendments to such
NantKWest Agreement to PEGA1 once executed. If the NantKWest Agreement terminates or may terminate, Roche shall use commercially reasonable efforts to maintain the applicable sub-license to PEGA1; if Roche is
not able to maintain the applicable sub-license, PEGA1 shall have the right to attempt to cure any breach giving rise to such actual or threatened termination and may credit any amounts paid by PEGA1 to
maintain any such sub-license against any amounts owed to Roche hereunder, provided that such amounts credited against any amounts owned to Roche hereunder shall not exceed the amount owed by Roche for the
respective license. 
  

	 	2.	 The following shall be added to the list of CMC materials in Appendix 4.3: 

 

					
	 Cell line
	  	 Cell Line Description
	  	 Shipment

	[####]	  	[####]	  	[####]

  

	 	3.	 Save as set out in this AMENDMENT NO 2, nothing shall vary, or be construed to vary the Agreement. The terms of
the Agreement shall remain in full force and effect. All terms not otherwise defined in this AMENDMENT NO 2 shall have the meaning given to them in the Agreement. 

 IN WITNESS WHEREOF, the Parties have caused this Amendment No 2 to be executed as of the Amendment Date
by their duly authorized representatives. 
  

	
	PEGA-ONE SAS
	
	 /s/ Jignesh Shah

	Name: Jignesh Shah
	Title: Head of Supply Chain and Quality
	Date: 31st August 2020

  

					
	F. Hoffmann-La Roche Ltd	 	    	  	
			
	 /s/ Timothy Steven
	 		  	 /s/ Barbara Schroeder

	Name: Tim Steven	 		  	Name: Barbara Schroeder
	Title: Global R&D Out Licensing Director	 		  	Title: Legal Counsel
	Date: 28th August 2020	 		  	

  

	
	Hoffmann-La Roche Inc.
	
	 /s/ John Parise

	Name: John Parise
	Title: Authorized Signatory
	Date: August 28, 2020

 Appendix 2.2.a 

 CONFIDENTIAL 

NON EXCLUSIVE LICENSE AGREEMENT 

This Non-Exclusive License Agreement (this “Agreement”), dated and effective as of
November 1, 2010 (“Effective Date”), is between F. Hoffmann-La Roche Ltd, a Swiss corporation with offices at Grenzacherstrasse 124, 4070 Basel, Switzerland (“ROCHE”), and
CONKWEST INC. (“Conkwest”), an Illinois corporation having an office and place of business at 3790 Via De La Valle, Ste. 205, San Diego, Ca 92014, USA. 

PREAMBLE 
 A. Conkwest is
the owner of, and/or controls the rights in, certain Intellectual Property (as defined herein) and Cell Lines (as defined herein) and has the right to grant licenses thereto. 

B. ROCHE desires to obtain a license to use the Intellectual Property and Cell Lines upon the terms and conditions hereinafter set forth. 

NOW THEREFORE, in consideration of the above premises and the mutual covenants • contained herein, ROCHE and Conkwest agree as follows:

 AGREEMENT 
 1. Definitions. For the
purposes hereof, the following words and phrases shall have the following meanings: 
 “Affiliate” means: 

(a) an organization which directly or indirectly controls a party to this Agreement; 

(b) an organization, which is directly or indirectly controlled by a party to this Agreement; 

(c) an organization, which is controlled, directly or indirectly, by the ultimate parent company of a party; 

“Control” as per a) to c) is defined as owning more than fifty percent of the voting stock of a company or having otherwise the power
to govern the financial and the operating policies or to appoint the management of an organization. 
 With respect to ROCHE the term
Affiliate shall not include Chugai Pharmaceutical Co. Ltd., l-l, Nihonbashi-Muromachi 2-chome, Chuo-ku Tokyo, 103-8324, Japan (“Chugai”), unless ROCHE opts for
such inclusion of Chugai by giving written notice to Conkwest, provided that Chugai qualifies as an Affiliate pursuant to this section. 

 “Antibody Products” means any (i) antibody, or (ii) protein
comprising at least one complementarity determining region (CDR) (including bispecific antibodies, single chain antibodies, domain antibodies and immunoconjugated antibodies), and/or (iii) protein comprising a domain available for binding to an
Fc receptor, whether human, humanized, chimeric, murine, synthetic or from any other source that is controlled by ROCHE or its Affiliates. 

“Biological Material’’ means a culture of any of the Cell Lines that is provided to ROCHE by Conkwest pursuant to this
Agreement (as set forth in Appendix B hereto) and all progeny thereof. 
 “Cell Lines” means: [####] 

“Commercial Product” means a product that has been granted marketing and regulatory approval wherein: (i) the batch or
quality control assays for release of the product utilizes or is derived from the Cell Lincs; and/or (ii) the use of the batch or quality control assays for release of the product would, but for the license granted herein, infringe a Valid
Claim of the Patents. 
 “Confidential Information” means: 

 

	 	(i)	 in the case of ROCHE, the Know How and other information disclosed by Conkwest or its Affiliates to ROCHE or
its Affiliates pursuant to the terms of this Agreement; and 

  

	 	(ii)	 in the case of Conkwest, the information disclosed by ROCHE or its Affiliates to Conkwest or its Affiliates
pursuant to the terms of this Agreement; and 

  

	 	(iii)	 for both Parties: 

  

	 	a.	 trade secrets or information relating to the business affairs or finances of the other of third parties and
disclosed to them or coming into their possession for the performance of this Agreement; and 

  

	 	b.	 the terms and conditions of the Agreement. 

“First Commercial Safe” shall mean the first invoiced sale of a Commercial Product to a third party by Roche, it’s
Affiliates or permitted sublicensees following the receipt of any Regulatory Approval required for the sale of such Commercial Product, if any. 

“Force Majeure” shall mean in relation to either Party, any event or circumstance (other than lack of funds) which is beyond
the reasonable control of that Party which event or circumstance that Party could not reasonably be expected to have taken into account at the date of this Agreement and which results in or causes the failure of that Party to perform any or all of
its obligations under this Agreement including act of God, lightning, fire, storm, flood, earthquake, accumulation of snow or ice, lack of water arising from weather or environmental problems, strike, lockout or other industrial or student
disturbance, act of the public enemy, war declared or undeclared, threat of war, terrorist act, blockade, revolution, not, insurrection, civil commotion, 

  
 -2- 

 public demonstration, sabotage, act of vandalism, prevention from or hindrance in obtaining in any way
materials, energy or other supplies, explosion, fault or failure of plant or machinery (which could not have been prevented by good industry practice), or legal requirement governing either Party’. 

“Intellectual Property” means the Patents and Know How controlled by Conkwest (with the right to permit access to ROCHE),
owned by Conkwest as of the Effective Date or licensed to Conkwest (with the right to permit access to ROCHE) during the Term (as hereinafter defined). 

“Indemnitees” means agents, directors, officers and employees, and their respective successors, assigns, administrators,
executors and/or heirs, 
 “Know How” means the know how that relates to the Cell Lines, as set out in Appendix B, that is
owned or controlled by Conkwest or its Affiliates as of the date of this Agreement. 
 “Patents” means all patents and
patent applications owned or controlled by Conkwest which relate directly to the Cell Lines including those listed in Appendix A and any provisional patent applications, non-provisional applications,
divisionals, continuations, continuation-in-part applications, continued prosecution, patents granted on such applications, reissues, renewals, substitutions,
supplementary protection certificates and the like, and patents of addition, reexaminations, extensions; and all foreign counterparts thereof. 

“Party” or “Parties” means Conkwest, ROCHE, or both, depending on the context. 

“Purpose” means research, development, manufacture, commercialization, sale, use or other disposal of Antibody Products by
ROCHE and its Affiliates, including without limitation the following: 
  

	 	(i)	 Cell-based assays for use in discovery of Antibody Products; 

 

	 	(ii)	 High through-put screening of Antibody Products; 

 

	 	(iii)	 Characterization of one or more Antibody Products, commercial or otherwise; 

 

	 	(iv)	 Batch or quality control release assays for one or more Antibody Products; 

 

	 	(v)	 Stability assay for one or more Antibody Products; 

 

	 	(vi)	 In vitro assays for detecting neutralizing antibodies against one or more Antibody Products, and/or

  

	 	(vii)	 Other research and development purposes pertaining to Antibody Products. 

For the avoidance of doubt, this definition and the licenses granted herein do not include sale of the Cell Lines either alone or as part of a
kit. 

  
 -3- 

 “Tax” means all charges, duties, fees, levies or other assessments imposed
by any tax authority, including but not limited to income, excise, property, sales, use, value added, profit, license, payroll, employment, net worth, capital gains, transfer, stamp, social security, environmental, occupation and franchise taxes,
and includes any interest, penalties and additions on these payments. 
 “Term” shall have the meaning ascribed to it in
Section 8. 
 “Valid Claim” means a claim of any issued or pending Patent whose enforceability has not been affected
by one or more of any of the following: (i) irretrievable lapse, revocation or abandonment and/or (ii) holding of unenforceability or invalidity by a decision of a court or other appropriate body of competent jurisdiction, unappealable or
unappealed within the time allowed for appeal, and/or (iii) disclaimer or admission of invalidity or unenforceability through reissue or re-examination or opposition, nullity action or invalidation suit
response or otherwise. 
  

	2.	 Grant of Rights. 

(a) License Subject to the terms and conditions of this Agreement, Conkwest hereby grants to ROCHE and its Affiliates during the Term, for the
Purpose, a worldwide, non-exclusive, license, with the limited right to sublicense; 
  

	 	(i)	 under the         Patents; 

 

	 	(ii)	 under the         Know How; and/or 

 

	 	(iii)	 under the         Cell Lines. 

(b) Sublicense Rights. For purposes of clarity, ROCHE or its Affiliates are only entitled to sublicense the rights granted herein
(including the right to distribute the Cell Lines) to: 
  

	 	(i)	 third parties that are performing contract services for and on behalf of ROCHE or its Affiliates in relation to
its Antibody Products to the extent necessary to perform such contract services and consistent with the Purpose; and 

  

	 	(ii)	 third parties who have acquired or licensed the Antibody Products from ROCHE and/or its Affiliates to the
extent necessary to utilize such acquired or licensed products and consistent with the Purpose. 

 (c) Transfer of
Biological Material and Know How. As set forth in Section 4(d) hereto, Conkwest shall make available to ROCHE the Biological Material and the Know How as enumerated in Appendix B. Conkwest shall be responsible for the cost of transferring
Know How and Biological Material to ROCHE. 

  
 -4- 

 (d) Licensee and Sublicensee Compliance. ROCHE will and will undertake that its
sublicensees will comply with all laws, rules, regulations and guidelines which apply to the use of the Biological Material and the Know How, including without limitation, those promulgated by the U.S. Food and Drug Administration (or the foreign
local equivalent), and those relating to the export and import of the Biological Material and the Know How, 
  

	3.	 Payments. 

(a) Upfront Fee. Following execution of the Agreement, ROCHE shall pay Conkwest an Upfront Fee of [####] within [####] from receipt of a
correct invoice from Conkwest. 
 (b) Research License Fee. During the Term, ROCHE will additionally pay Conkwest a research license fee of
[####] on each anniversary of the Effective Date. Such amount is payable within [####] days after receipt of a correct invoice from Conkwest The research license fee is only payable until sale of the first Commercial Product. 

(c) Commercial License Fee. If a Commercial Product reaches a First Commercial Sale in the US or in the EU, then ROCHE shall pay Conkwest
[####] within [####] from receipt of a correct invoice. 
 A commercial event payment in the US or EU shall be paid [####]a Commercial Product. [####] 

(d) Method of Payment. All payments to Conkwest hereunder shall be made payable to Conkwest and sent to the address identified in
Section 10 or remitted to Conkwest’s account at a bank to be designated by Conkwest in writing and sent to ROCHE in advance of such payment. 

(e) Third Party Payments. Conkwest is responsible for all payments to third parties that are owed as a result of the licenses granted by
Conkwest under Section 2(a) for the unmodified Cell Lines. For the avoidance of doubt, Conkwest is only responsible to provide the licenses, granted herein to ROCHE, free and clear of third party payment obligations. Notwithstanding the
foregoing, ROCHE is responsible for obtaining, at its expense, any third party licenses required to develop and commercialize its products, including the Commercial Products. 

(f) Payments in U.S. Dollars. All payments due hereunder are payable in United States dollars. 

(g) Taxes: 
  

	 	(i)	 All payments due hereunder are inclusive of indirect Taxes subject however to Section 3(g)(ii) below. If
any indirect Taxes are chargeable in respect of any payments, ROCHE shall pay such indirect Taxes at the applicable rate in respect of any such payments following the receipt, where applicable, of an indirect Taxes invoice in die appropriate form
issued by Conkwest in respect of those payments. The indirect Taxes shall be payable on the due date of the payment to which such indirect Taxes relate. 

  
 -5- 

	 	(ii)	 ROCHE may deduct withholding Taxes from the payment it owes Conkwest under this Agreement. ROCHE will, on
behalf of Conkwest, pay the withheld Tax to the appropriate authority and provide Conkwest with proof of payment and evidence of the tax obligation. ROCHE will at Conkwest’s request and expense provide Conkwest reasonable assistance in
recovering these withholding taxes. 

 (h) Notification of Commercialization of Products. ROCHE shall notify
Conkwest [####] of the number of Commercial Products that are subject to the Commercial License Fees under Section 3(c). For clarity, an omission of ROCHE to notify Conkwest does not constitute material breach of this Agreement. 

4. Ownership and Results. 
 (a) ROCHE
acknowledges that subject to the licenses granted hereunder, all right, title and interest in the Biological Material and Know How provided to ROCHE under this Agreement shall remain the sole property of Conkwest. ROCHE further agrees that it shall
not modify or improve the Biological Materia! in any way, inclusive of genetic modification and manipulation, and that it shall not use the Biological Material for anything other than the Purpose. Furthermore, Roche shall ensure that its Affiliates
and permitted sublicensees are likewise subject to the restrictions staled in this section 4(a). 
 (b) Subject to the limitations set forth
in Section 4(a) hereto, all right, title, and interest in any results, data, information, inventions, intellectual property, know-how and all other industrial or intellectual property rights of any nature
whatsoever (collectively, “Results”) arising in any part of the world developed by ROCHE (by itself and its Affiliates or in collaboration with Third Parties) as a result of its use of the Biological Material and Know How for the Purpose
shall be the exclusive property of ROCHE, and Conkwest shall have no rights therein. In case of exploitation of the Results by ROCHE or its Affiliates, Conkwest and/or any of its employees and/or collaborators shall not be entitled to any royalties,
or other rights of compensation whatsoever. With respect to Results, ROCHE shall be entitled to file in its own name relevant patent applications and resultant patent rights shall also be owned by ROCHE. Conkwest shall execute any instruments which
ROCHE shall deem necessary to apply for and obtain letters of patent and ROCHE shall compensate Conkwest for the time devoted to said activities and reimburse Conkwest for any reasonable expense incurred. 

ROCHE shall have the unrestricted right to publish or otherwise disclose Results obtained by the practice of the rights granted ROCHE under this Agreement
provided such disclosure does not include the Confidential Information of Conkwest. The name of Conkwest shall be given proper recognition in such publication(s) as scientifically appropriate. 

(c) ROCHE shall have no obligation whatsoever to share such Results with Conkwest and ROCHE shall be entitled to deal with, protect, exploit
and dispose of such rights in its sole discretion and in any manner. 

  
 -6- 

 (d) Conkwest shall transfer the Biological Material in satisfactory condition to ROCHE,
without charge for handling and delivery therefore, within [####] following receipt of Upfront Fee. At the time of the provision of the Biological Material to ROCHE, Conkwest shall provide ROCHE a report (the “Conkwest Report”) containing
Know How related to the Biological Material as set forth in Appendix B. The Conkwest Report shall be regarded (at all times) as Conkwest Confidential Information. The Biological Material and Conkwest Report shall be sent to: 

[####] 
 F. Hoffmann-La Roche Ltd 
 [####] 

Grenzacherstrasse 124 4070 Basel, Switzerland 

(e) Except as provided in this Agreement, ROCHE shall not sell, transfer, assign or otherwise provide any third party access to the
Biological Material or Know How. 
  

	5.	 Representations and Warranties. 

(a) Each Party hereby represents and warrants to the other Party as of the Effective Date that: 

 

	 	(i)	 it is a corporation duly organized, validly existing and in good standing under the laws of the jurisdiction in
which it is incorporated; 

  

	 	(ii)	 it has the corporate power and authority and the legal right to enter into this Agreement free from any
conflicting right owed to a third party and to perform its obligations hereunder; 

  

	 	(iii)	 it has taken all necessary corporate action on its part to authorize the execution and delivery of this
/Agreement and the performance of its obligations hereunder and that this Agreement has been duly executed and delivered on behalf of each Party, and constitutes a legal, valid, binding obligation, enforceable against such Party in accordance with
its terms; 

  

	 	(iv)	 all necessary consents, approvals and authorizations of all applicable competent authorities and other persons
required to be obtained by such Party in order to execute this Agreement on behalf of such Party have been obtained; and 

  
 -7- 

	 	(v)	 the execution and delivery of this Agreement and the performance of such Party’s obligations do not
constitute a default or require any consent under any other contractual obligation of such Party. 

 (b) Conkwest hereby
represents and warrants to ROCHE that as of the Effective Date: 
  

	 	(i)	 Conkwest owns or otherwise controls the Intellectual Property and the Cell Lines free of any third party
rights, claims or encumbrances, 

  

	 	(ii)	 Conkwest has the right to grant to ROCHE the licenses set out in this Agreement; 

 

	 	(iii)	 I here has not been in the past and is not as of the Effective Date any challenge to the Intellectual Property
and/or the Cell Lines by any third party for which actual notice has been received by Conkwest; 

  

	 	(iv)	 The Cell Lines do not contain any trade secrets or other rights or property of any third party;

  

	 	(v)	 There are no claims, judgments or settlements with respect to the Intellectual Property and Cell Lines and no
claim or litigation has been brought or, to Conkwest’s knowledge, threatened by any person alleging so and Conkwest is not aware of any possible claim, whether or not asserted, that the Cell Lines or the use or exploitation thereof infringes,
conflicts or interferes with any intellectual property or proprietary right of any third party; and 

  

	 	(vi)	 Conkwest has not previously entered into any agreement, whether written or oral, with respect to the Cell Lines
or the Intellectual Property which conflicts with the rights granted to ROCHE hereunder and Conkwest will not enter into any such agreement during the term of this Agreement. 

 

	6.	 Indemnification. 

(a) ROCHE shall indemnify, defend and hold harmless Conkwest and its Indemnitees from and against any and all claims, losses, demands,
liabilities, judgments, actions, causes of action, costs and expenses, of any type or kind (including reasonable attorneys’ fees) (collectively “Claims”), brought by a third party, if the Claims: 

 

	 	(i)	 result from the breach by ROCHE of the Agreement; 

 

	 	(ii)	 result from the development, commercialization, sale, distribution or use of a Commercial Product by ROCHE or
its Affiliates or permitted sublicensees; or 

  
 -8- 

	 	(iii)	 result from any use of the Cell Lines for the Purpose by ROCHE or its Affiliates or permitted sublicensees;

  

	 	provided,	 however, that ROCHE shall not be obliged to indemnify Conkwest and its Indemnities under this Section 6(a)
to the extent the Claims are a result of negligence or willful misconduct of Conkwest or its Affiliates or its Indemnitees. 

(b) Conkwest shall indemnify, defend and hold harmless ROCHE and its Indemnitees from and against any and all Claims brought by a third party,
if the Claims: 
 (i) result from a breach of Conkwest’s warranties under Section 5 hereinabove; or 

(ii) result from the breach by Conkwest of the Agreement; provided, however, that Conkwest shall not be obliged to indemnify ROCHE and its
Indemnitees under this Section 6(b) to the extent the Claims are a result of negligence or willful misconduct of ROCHE or its Affiliates or its Indemnitees. 

(c) Disclaimer of Warranties. EXCEPT AS SPECIFICAI.LY STATED IN SECTION 5 ABOVE, CONKWEST MAKES NO REPRESENTATIONS AND EXTENDS NO WARRANTIES OF
ANY KIND, EITHER EXPRESS OR IMPLIED. WARRANTIES DISCLAIMED INCLUDE, BUT ARE NOT LIMITED) TO, ANY EXPRESS OR IMPLIED WARRANTIES OF DESIGN, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE; OR ARISING FROM A COURSE OF DEALING, USAGE OR TRADE
PRACTICE. 
 (d) Limitations of Liability. IN NO EVENT WILL EITHER PARTY BE LIABLE FOR ANY LOST REVENUES, LOST PROFITS, OR OTHER INCIDENTAL,
SPECIAL, INDIRECT OR CONSEQUENTIAL DAMAGES ARISING OUT OF THIS AGREEMENT OR ITS BREACH, EVEN IF THEY HAVE BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES. FOR THE AVOIDANCE OF DOUBT, DIRECT FINANCIAL OR OTHER LOSSES, INCLUDING LOSSES RESULTING FROM
ROCHE’S BREACH OF THE SCOPE OF THE LICENSE THAT HAS NOT BEEN CURED BY ROCHE WITHIN THIRTY (30) DAYS OF NOTIFICATION BY CONKWEST, ARE EXCLUDED FROM THIS PROVISION. 

(e) The provisions of this Section survive termination. 
  

	7.	 Confidentiality 

(a) Each Party may with respect to the other party’s Confidential Information 

 

	 	(i)	 only use the Confidential Information for the purposes envisaged under this Agreement; 

 

	 	(ii)	 ensure that only those of its officers and employees who are directly concerned with the carrying out of this
Agreement have access to the Confidential Information on a strictly applied “need to know” basis and are informed of the secret and confidential nature of it; 

  
 -9- 

	 	(iii)	 keep the Confidential Information secret and confidential and not directly or indirectly disclose or permit to
be disclosed, make available or permit to be made available the same to any third party for any reason without the prior written consent of the disclosing Party; 

 

	 	(iv)	 ensure that the Confidential Information is not covered by any fixed or floating charge entered into at any
time by it and not otherwise to establish a lien over or in any other way encumber the same; and 

  

	 	(v)	 not copy, reproduce or otherwise replicate for any purpose or in any manner whatsoever any documents containing
the Confidential Information, except that each party may retain one copy of the Confidential Information for purposes of ensuring its compliance with this Agreement 

(b) The obligations of confidence referred to in Section 7(a) shall not extend to any Confidential Information which: 

 

	 	(i)	 is or becomes generally available to the public otherwise than by reason of breach by a recipient Party of the
provisions of this Section; 

  

	 	(ii)	 is known to the recipient Party and is at its free disposal (having been generated independently by the
recipient Party or a third party in circumstances where it has not been derived directly or indirectly from the disclosing Party’s Confidential Information) prior to its receipt from the disclosing party provided that evidence of such knowledge
is proven by competent written records; 

  

	 	(iii)	 is subsequently disclosed to the recipient Party without obligations of confidence by a third party owing no
such obligations to the disclosing Party in respect of that Confidential Information; or (iv) is required by law to be disclosed (including, without limitation, as part of any regulatory submission or approval process); however, the Party
seeking such disclosure shall provide prompt written notice of this requirement to the disclosing Party so that it may, if so advised, seek appropriate relief to prevent such disclosure provided always that in such circumstances such disclosure
shall be only to the extent so required and shall be subject to prior consultation with the disclosing Party with a view to agreeing timing and content of such disclosure. 

  
 -10- 

 (c) All Confidential Information owned by and disclosed by the disclosing Party to the
recipient Party shall remain the property of the disclosing Party. In the event that a court or competent authority assumes partial or complete or complete control over the assets of recipient party based on the insolvency or bankruptcy of that
Party, the recipient Party shall promptly notify such court or Competent Authority that (i) Confidential Information received from the disclosing Party under this Agreement remains the property of the disclosing Party, and (ii) of the
confidential obligations under this Agreement; end to the extent permitted by law, take all steps stops necessary or desirable to maintain the confidentiality and security of the disclosing Party s Confidential Information and to ensure that the
court or competent authority maintains that Confidential Information in confidence in accordance with this Agreement 
 (d) The
obligations of the Parties under Section 7 shall last for a period of [####] after disclosure the Confidential Information The requirement under Section 7(b)(iv) to notify the disclosing Party when Confidential Information is required to
be disclosed by law shall not apply when such disclosure is required as part of any regulatory submission or approval process. 
  

	8.	 Term Termination 

(a) This Agreement shall come into force on the Effective Date and remain in full force and effect, unless earlier terminated as herein
provided, until [####], After the term of this Agreement pursuant to this Section 8(a), the license granted under Section 2 shall he fully paid-up, perpetual and irrevocable. 

(b) Termination for Insolvency. 
  

	 	(i)	 If voluntary or involuntary proceedings by or against a Party are instituted in bankruptcy under any insolvency
law, or a receiver or custodian is appointed for such Party, or proceedings are instituted by or against such Party, in each of the foregoing cases only if it is for dissolution of such Party, which proceedings, if involuntary, shall not have been
dismissed within [####] after the date of filing, then this Agreement may be terminated by the other Party. 

  

	 	(ii)	 All rights and licenses granted under this Agreement are, and shall be deemed to be, for purposes of
Section 365(n) of the United States Bankruptcy Code, licenses of rights to “intellectual property” as defined under Section 101(56) of the United States Bankruptcy Code. If the commencement of a bankruptcy proceeding by or
against Conk west under the United States Bankruptcy Code, ROCHE shall be entitled to complete access to any such intellectual property, and all embodiments of such intellectual property, pertaining to the rights granted in the licenses hereunder of
Conkwest by or against whom a bankruptcy proceeding has been commenced, subject, however, to payment of the fees, set forth in this Agreement through the effective date of any termination hereunder. 

  
 -11- 

 (c) Conkwest has the right, upon [####]prior written notice to ROCHE, to terminate this
Agreement, including all licenses hereunder if ROCHE fails to comply materially with any of the terms and conditions hereof; provided, that during such [####]notice period, ROCHE shall be permitted to cure any such default occurring hereunder. 

(d) If Conkwest is in material breach of the Agreement, then in addition to any rights or remedies available to ROCHE, ROCHE may terminate this
Agreement upon [####]prior written notice unless Conkwest cures the breach within the [####] time period. Following termination under this subsection, ROCHE will have a fully paid up, perpetual and irrevocable licence as set out in Section 2
above. 
 (e) ROCHE shall have the right, upon [####] prior written notice to Conkwest to terminate the Agreement for any reason in
ROCHE’s sole discretion. 
 (f) In the event of termination of this Agreement under subsections (c) or (e) above (or due to
ROCHE’s insolvency or bankruptcy under subsection (c) above), the licenses granted hereunder shall terminate ROCHE will destroy the Cell Lines and return all Confidential Information within [####] following termination tinder such
subsection, and ROCHE specifically agrees no further use of the Cell Lines or Know How for any purpose. 
 9. Assignment. This Agreement including
the rights and privileges granted hereunder may not be assigned by either Party without the prior written consent of the other Party; provided, however, that either Party may, without the other Party’s consent, assign this Agreement and its
rights and obligations hereunder to an Affiliate or in connection with the transfer or sale of all or substantially all of its business, or in the event of its merger, consolidation, change in control or other similar transaction. This Agreement is
binding upon and will inure to the benefit of the Parties, its successors and permitted assigns. 
 10. Notice Address. Any payment, notice or other
communication pursuant hereto shall be sufficiently made or given on the date of receipt if sent to the other Party, certified or registered mail postage prepaid, addressed to it at its address below or at such other address as a Party may later
designate by written change of address notice given to the other Party: 
  

			
	Conkwest Inc.	  	F. I Hoffmann-La Roche Ltd Grenzacherstrasse
		
	3790 Via De La Valle, Ste. 205	  	124,
		
	San Diego, Ca 92014	  	4070 Basel. Switzerland
		
	Attention: [####]	  	Attention: Head of Technical Development
		
	President & CEO	  	Biologics Europe
		
	Telephone: [####]	  	
		
	Facsimile: [####]	  	
		
	E-mail: [####]	  	With copies to:
		
		  	F. Hoffmann-La Roche Ltd Grenzacherstrasse
		
	With copies to:	  	124,

  
 -12- 

			
	Cohen & Grigsby, P.C.	  	4070 Basel, Switzerland
		
	Dominion Tower	  	Attention: General Counsel
		
	625 Liberty Avenue	  	

 Pittsburgh, Pennsylvania 15222-3152 

Attention: [####]. 
 Telephone: [####] 

Facsimile: [####] 

E-mail: [####] 

11. Headings. All headings are for convenience only and shall not affect the meaning of any provision hereof. 

12. Force majeure. If a Party (the “Non-Performing Party”) is, unable to carry out any of its
obligations under this Agreement due to Force Majeure, this Agreement shall remain in effect but the Non-Performing Party’s relevant obligations under this Agreement and the corresponding obligations of
the other Party (the “Innocent Party”) under this Agreement, shall be suspended for a period equal to the circumstance of Force Majeure, provided that; 

(a) the suspension of performance is of no greater scope than is required by the Force Majeure; 

(b) the Non-Performing Party gives the Innocent Party prompt written notice describing the
circumstance of Force Majeure, including the nature of the occurrence and its expected duration, and continues to furnish regular reports during the period of Force Majeure; 

(c) the Non-Performing Party uses all reasonable efforts to remedy its inability to perform and to
mitigate the effects of the circumstance of Force Majeure; and 
 (d) as soon as practicable after the event which constitutes Force
Majeure the Parties discuss how best to continue their operations as far as possible in accordance with this Agreement 
 13. Entire Agreement. This
Agreement contains the entire understanding of the parties with respect to the subject matter herein and supersede all previous agreements and undertakings with respect thereto. 

14. Miscellaneous. This Agreement may be amended only by a writing signed by each of the parties 

15. Survival: The following provisions of the Agreement shall survive expiry or termination of the Agreement; Sections 4, 6, 7, 8, 15, 16 and 17 

  
 -13- 

 16. Governing Law and Jurisdiction. All disputes between the Parties arising out of the circumstances
and relationships contemplated by this Agreement including disputes relating to the validity, construction or interpretation of this Agreement are subject to the exclusive jurisdiction of the State of New Jersey except for disputes relating to
patent validity which shall be determined by the relevant national court. 
 17. Severance of Terms: If the whole or any part of this Agreement is or
becomes or is declared illegal, invalid or unenforceable in any jurisdiction for any reason (including both by reason of the provisions of any legislation and also by reason of any decision of any court or competent authority which either has
jurisdiction over this Agreement or has jurisdiction over any of the Parties)’ 
 (a) in the case of the illegality, invalidity or
unenforceability of the whole of this Agreement it shall terminate in relation to the jurisdiction in question; or 
 (b) in the case of
the illegality, invalidity or unenforceability of part of this Agreement that part shall he severed from this Agreement in the jurisdiction in question and that illegality, invalidity or unenforceability shall not in any way whatsoever prejudice or
affect the remaining parts of this Agreement which shall continue in full force and effect. 
 18. Waiver: The waiver by a party of any breach or
violation of any provision hereof shall not operate or be construed a waiver of any subsequent breach or violation hereof. 
 19. Export: It is
understood that the Cell Lines and Know How provided or made available by Conkwest under this Agreement are subject to applicable laws and regulations controlling the export and import of technical data, biological materials, laboratory prototypes,
and other information or materials that may require a license from the applicable agency of the United States Government or foreign government, and ROCHE and its Affiliates will comply with al! such laws and regulations. Conkwest neither represents
that a license will not be required nor does Conkwest represent that if a license is required, it will be issued. 
 20. No Additional Rights:
Nothing contained herein shall be construed to confer any rights upon either Party by implication, estoppel, or otherwise as to any technology or patent rights of the other Party other than the Intellectual Property’ and the Cell Lines and only
as expressly set forth herein. 
 21. Reservation of Rights. All rights not specifically granted to ROCHE and its Affiliates herein are expressly
reserved by Conkwest. 
 22. Counterparts. This Agreement may be executed in counterparts with the same effect as if both Parties had signed the same
document All such counterparts will be deemed an original, will be construed together and will constitute one and the same instrument. Signature pages of this Agreement may be exchanged by facsimile or other electronic means without affecting the
validity thereof. 

  
 -14- 

 SIGNATURE PAGE FOLLOWS 

  
 -15- 

 SIGNATURE PAGE TO NON-EXCLUSIVE LICENSE AGREEMENT

 IN WITNESS WHEREOF, the Parties have caused this Agreement to be executed by their duly authorized representatives. 

 

					
	CONKWEST INC.:	 		  	F. Hoffmann-La Roche Ltd
			
	By:
                                         
                       	 		  	By
                                         
                       
	Name: Barry J. Simon, M.D.	 	    	  	Name:
	Title: President and CEO	 		  	Title:
	Date:                                 	 		  	Date                                 
			
		 		  	By:
                                         
                       
		 		  	Name:
		 		  	Title:
		 		  	Date:                                 

  
 -16- 

 APPENDIX A 

[####]  

 APPENDIX B 

[####]EX-10.11

 Exhibit 10.11 

[####] Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) would be
competitively harmful if publicly disclosed. 
 DATED 2015 

CAMBRIDGE ENTERPRISE LIMITED (1) 

(“CE”) 
 and

 Z FACTOR LIMITED (2) 

(“Licensee”) 
  

 
 LICENCE
AGREEMENT 
  
  

Case No: [####] 
  

 
  

  
 Page 1 of 29 

 

							
	 1.
	 	Definitions and Interpretations	  	 	1	 
	 1.1
	 	Definitions	  	 	1	 
	 1.2
	 	Interpretation	  	 	3	 
	 1.3
	 	Schedules	  	 	4	 
	 2.
	 	Grant of rights	  	 	4	 
	 2.1
	 	Licences	  	 	4	 
	 2.2
	 	Formal licences	  	 	4	 
	 2.3
	 	Sub-licensing	  	 	4	 
	 2.4
	 	Reservation of rights	  	 	5	 
	 2.5
	 	Licensing of Improvements	  	 	5	 
	 3.
	 	Confidentiality	  	 	6	 
	 3.1
	 	Provision of Know-how	  	 	6	 
	 3.2
	 	Parties to treat Know-how as confidential	  	 	6	 
	 3.3
	 	Confidentiality	  	 	7	 
	 3.4
	 	Use of Confidential Information	  	 	8	 
	 3.5
	 	Disclosing Confidential Information	  	 	8	 
	 3.6
	 	Exceptions to confidentiality obligations	  	 	8	 
	 3.7
	 	Return of Confidential Information and survival of confidentiality obligations	  	 	8	 
	 4.
	 	Payments	  	 	9	 
	 4.1
	 	Initial payment and reimbursement of costs	  	 	9	 
	 4.2
	 	Milestone payments	  	 	9	 
	 4.3
	 	Payment terms	  	 	9	 
	 4.4
	 	Financial Reports	  	 	10	 
	 4.5
	 	Records	  	 	10	 
	 4.6
	 	Responsibility for discharging out of payments	  	 	10	 
	 4.7
	 	Equity	  	 	10	 
	 5.
	 	Commercialisation obligations and reports	  	 	11	 
	 5.1
	 	Commercialisation	  	 	11	 
	 5.2
	 	Commercialisation Reports	  	 	11	 
	 5.3
	 	Independent Expert - Reference	  	 	12	 
	 5.4
	 	Independent Expert- appointment and decision	  	 	12	 
	 5.5
	 	GE’s right to terminate	  	 	12	 
	 6.
	 	Intellectual property	  	 	12	 
	 6.1
	 	Patent protection	  	 	12	 
	 6.2
	 	Infringement of the Licensee Patents	  	 	12	 

							
	 6.3
	 	Infringement of third party rights	  	 	13	 
	 7.
	 	Warranties and liability	  	 	13	 
	 7.1
	 	Status of Licensed Technology	  	 	13	 
	 7.2
	 	No representations or warranties	  	 	13	 
	 7.3
	 	Liability and indemnity	  	 	14	 
	 8.
	 	Duration and termination	  	 	15	 
	 8.1
	 	Term	  	 	15	 
	 8.2
	 	Early termination by the Licensee	  	 	15	 
	 8.3
	 	Early termination by CE	  	 	15	 
	 8.4
	 	Early termination by either Party	  	 	15	 
	 8.5
	 	Consequences of termination	  	 	15	 
	 9.
	 	Dispute resolution	  	 	16	 
	 10.
	 	General	  	 	16	 
	 10.1
	 	Force majeure	  	 	16	 
	 10.2
	 	Assignment	  	 	17	 
	 10.3
	 	Waiver	  	 	17	 
	 10.4
	 	Invalid clauses	  	 	17	 
	 10.5
	 	No agency	  	 	17	 
	 10.6
	 	Notices	  	 	17	 
	 10.7
	 	Law and jurisdiction	  	 	18	 
	 10.8
	 	Further action	  	 	18	 
	 10.9
	 	Announcements	  	 	18	 
	 10.10
	 	Entire agreement	  	 	18	 
	 10.11
	 	Third party rights	  	 	18	 
	 10.12
	 	Export Control Regulations	  	 	18	 
	 10.13
	 	Non-use of names and marking of Licensed Products	  	 	19	 
	 10.14
	 	insurance	  	 	19	 
	 10.15
	 	Counterparts	  	 	19	 
	 10.16
	 	Legal Compliance	  	 	19	 
	 SCHEDULE 1
	  	 	21	 
	 Part A: The Creators
	  	 	21	 
	 Part B: Specific Know-how, Materials and CE
Data
	  			
	 SCHEDULE 2 Appointment of Expert
	  	 	22	 
	 SCHEDULE 3
	  	 	23	 
	 Part A: Payment and Report Schedule
	  	 	24	 
	 Part B: Financial Report Format
	  	 	26	 
	 SCHEDULE 4 DEVELOPMENT PLAN
	  	 	27	 
	 SCHEDULE 5
	  	 	27	 

 
 

  
 Page 2 of 29 

			
	 THIS AGREEMENT dated
	  	 2015 is between:

  

	(1)	 CAMBRIDGE ENTERPRISE LIMITED (“CE”), a company incorporated in England and Wales
(registered number 1069886) whose registered address is at The Old Schools, Trinity Lane, Cambridge CB2 1TN, UK; 

 and 

 

	(2)	 Z FACTOR LIMITED (the “Licensee”), a company incorporated in England and Wales
(registered number 09274181) whose registered office is at c/o Index Venture Management LLP, 3 Burlington Gardens, Mayfair, London, England W1S 3EP. 

RECITALS: 
  

	(A)	 CE is a company wholly owned by the University (as defined below). 

 

	(B)	 The University creators as specified in Schedule 1 have developed certain technology relating to small molecule
chaperones to correct the folding of Z-alpha-1-antitrypsin, including the Licensed Technology. 

 

	(C)	 The University and Creators have each licensed their interest in the Licensed Technology to CE.

  

	(D)	 CE owns certain data related to the technology as a result of work it has commissioned with third parties.

  

	(E)	 The Licensee wishes to acquire rights in relation to the technology to enable the development and
commercialisation of small molecule chaperones to correct the folding of Z-alpha-1- antitrypsin in the Field and in the Territory
(all as defined below), and CE is willing to grant such rights, all in accordance with the provisions of this Agreement. 

 IT IS AGREED
as follows: 
  

	1.	 Definitions and Interpretations  

 

	1.1	 Definitions  

In this Agreement, the following words shall have the following meanings: 

 

			
	Affiliate	  	In relation to a Party, means any entity or person which controls, is controlled by, or is under common control with that Party including, without limitation, any general partner, managing member, officer or director of the Party or
any venture capital fund now or hereafter existing that is controlled by one or more general partners or managing members of, or shares the same management or advisory company with, the Party. For the purposes of this definition, “control”
shall mean direct or indirect holding or control of a majority of either voting rights or rights to distribution of profit attaching to the share capital, stock or other participating interest (or, outside a Party’s home territory, such lesser
percentage as is the maximum, permitted level of foreign investment).
		
	Agreement	  	This document, including its Schedules.
		
	Anniversary	  	An anniversary of the Commencement Date.
		
	CE Data	  	The deliverables of services commissioned by CE and owned by CE listed in Schedule 1.

  
 Page 1 of 29 

			
	Commencement Date	  	The date of this Agreement.
		
	Confidential Information	  	(a) the terms of this Agreement;
		
		  	(b) the Know-how; and
		
		  	(c) any other information marked confidential (or otherwise designated to show expressly that it is imparted in confidence,) obtained directly or indirectly by one Party from the other Party;
		
	Creators	  	The creators listed in Schedule 1.
		
	Development Plan	  	The plan provided by the Licensee in Schedule 4
		
	Field	  	The development of small molecule chaperones to correct the folding of Z-alpha-1-antitrypsin.
		
	Improvements	  	Any and all improvements, modifications, revisions, new applications and other developments to or of the Licensed Technology or the Technical Know-how arising during the Term of this
Agreement
		
	Indemnitees	  	CE, the University, the University’s employees and students, and the Creators and Principal Investigator.
		
	Know-how	  	The Technical Information of CE, and the Creators in the Field which exists at the Commencement Date and which relates directly to exploitation in the Field and Territory of the Licensed Technology or Technical Know-how. Know-how includes the Specific Know-how, and the Technical Know-how.
		
	Licensable Improvement	  	Any Improvement which:
		
		  	(a) has been made or generated by or under the supervision of the Principal Investigator;
		
		  	(b) has been disclosed within [####] of the Commencement Date to CE;
		
		  	(c) is owned and controlled by the University; and
		
		  	(d) has been assigned or licensed to CE, and that CE is free to license.
		
	Licensed Technology	  	(a) the Materials;
		
		  	(b) the Specific Know-how; and
		
		  	(c) the CE Data.
		
		  	as specified in Schedule 1.
		
	Materials	  	Means the materials identified in Schedule 1
		
	Milestone	  	An event specified in clause 4.2 where the achievement of the event is in any way dependent upon or deploys or validates any of the Licensed Technology.
		
	Parties	  	CE and the Licensee, and “Party” shall mean either of them.

  
 Page 2 of 29 

			
	Payment Period	  	The payment periods specified in Schedule 3.
		
	Principal Investigator	  	[####]
		
	Specific Know-how	  	That part of the Know-how that is summarised in Schedule 1, being Know-how which is held solely by the Creators and relates specifically to the
development of the Licensed Technology in the Field which is not generally known to the public, and which is in the possession or control of CE at the Commencement Date.
		
	Sub-Licensee	  	Any third party granted a sub-licence of the rights in clause 2.1 by the Licensee, whether directly by the Licensee or through multiple levels of
sub-licensing.
		
	Technical Information	  	All knowledge, experience, materials, data and similar technical or regulatory information which might reasonably be of commercial interest to the Licensee in the research, development, design, manufacture, supply, importation or
use of the Licensed Technology.
		
	Technical Know-how	  	Any and all further know-how which is in the possession or control of CE at the Commencement Date, other than the Specific Know-how, and which is
relevant or useful for the development or commercial exploitation by the Licensee or its Sub-Licensee of the Licensed Technology in the Field; including technical information, data, knowledge, methods,
techniques, processes, systems, algorithms, calculations, formulae, results of experimentation, designs, statistics, records and all confidential information and data developed by the Creators as employees of the University.
		
	Term	  	The period specified in clause 8.1.
		
	Territory	  	Worldwide.
		
	University	  	The Chancellor, Masters and Scholars of the University of Cambridge.

  

	1.2	 Interpretation  

In this Agreement (except where the context otherwise requires): 
  

	 	(a)	 any reference to a clause or schedule is to the relevant clause of or schedule to this Agreement and any
reference to a sub-clause or paragraph is to the relevant sub-clause or paragraph of the clause or schedule in which it appears; 

 

	 	(b)	 the clause and schedule headings are included for convenience only and shall not affect the interpretation of
this Agreement; 

  

	 	(c)	 any reference to “person” or “persons” includes natural persons, firms, partnerships,
companies, corporations, associations, organisations, governments, states, foundations and trusts (in each case whether or not having separate legal personality); 

 

	 	(d)	 the singular includes the plural and vice versa; and 

 

	 	(e)	 words preceding “include”, “includes”, “including” and “included” shall
be construed without limitation by the words which follow those words. 

  
 Page 3 of 29 

	1.3	 Schedules  

The schedules form part of this Agreement. If a provision of a schedule is inconsistent with a provision of this Agreement, the latter
prevails. 
  

	2.	 Grant of rights  

 

	2.1	 Licences  

In consideration of the payments specified in clause 4 CE hereby grants to the Licensee subject to the provisions of this Agreement: 

 

	 	(a)	 an exclusive licence under the Licensed Technology (with the right to
sub-license, subject to clause 2.3 below) to use, research, develop, manufacture, have manufactured, market, sell, supply, offer for sale, distribute, import and export small molecule chaperones to correct the
folding of Z-alpha-1-antitrypsin only in the Field in the Territory; and 

 

	 	(b)	 a non-exclusive licence to use the Technical Know-how (with the right to sub-license, subject to clause 2.3 below), to use, research, develop, manufacture, have manufactured, market, sell, supply offer for sale,
distribute, import and export small molecule chaperones to correct the folding of Z-alpha-1-antitrypsin only in the Field in the
Territory. 

  

	2.2	 Formal licences  

The Parties shall execute such formal licences as may be necessary or appropriate for registration with relevant authorities in particular
territories. In the event of any conflict in meaning between any such licence and the provisions of this Agreement, the provisions of this Agreement shall prevail. Prior to the execution of formal licences (if any) referred to in this clause, the
Parties shall as far as possible have the same rights and obligations towards one another as if such licences had been granted. The Parties shall use reasonable endeavours to ensure that, to the extent permitted by relevant authorities, this
Agreement shall not form part of any public record. 
  

	2.3	 Sub-licensing  

The Licensee shall be entitled to grant sub-licences of its rights under this Agreement (and to permit
multiple levels of sub-licensing by Sub-Licensees), provided that: 
  

	 	(a)	 each sub-licence shall 

 

	 	(I)	 include terms which are equivalent to the obligations and limitations imposed on the Licensee under this
Agreement (including insurance obligations, the limitation of the lndemnitees’ liability and an indemnity to the lndemnitees); and 

  

	 	(II)	 not exclude the Contracts (Rights of Third Parties) Act 1999 in respect of any of the lndemnitees;

  

	 	(b)	 each sub-licence shall terminate automatically on the termination of
this Agreement for any reason subject to the right for Licensee to require CE to agree that if the Licensee so requests CE shall immediately upon termination grant to the Sub-Licensee a new licence on terms
identical to the terms of this Agreement (the “Step-in right”). The Step-in Right shall not arise: if this Agreement terminates (i) by effluxion of time;
or (ii) due to a breach of the sublicense by the Sub-Licensee causing the Licensee to be in breach of this Agreement, as a result of which CE terminated the Agreement; 

 

	 	(c)	 within [####]of the grant of any sub-licence the Licensee shall provide
to CE a true copy of it, redacted, to the extent required by any Sub-licensee, in respect of any financial provisions and without limiting the Licensee’s obligations under clauses 4.4 and 4.5;

  
 Page 4 of 29 

	 	(d)	 the Licensee shall, subject to clause 7.3(b) be responsible for
Sub-Licensees’ conduct and any breach of a sub-licence as if it had been a breach by the Licensee under this Agreement and the Licensee shall indemnify CE against
any loss, damages, costs, claims or expenses which are awarded against or suffered by CE as a result; and 

  

	 	(e)	 for the avoidance of doubt, all Sub-Licensees shall be treated as sub-licensees of the Licensee for the purposes of this Agreement, whether the rights are granted directly by the Licensee or by any Sub-Licensee. 

 

	2.4	 Reservation of rights  

 

	 	(a)	 There is reserved for the University and the Creators an irrevocable, world-wide, royalty-free, right to use
the Licensed Technology in the Field for 

  

	 	(I)	 academic publication and teaching; 

 

	 	(II)	 academic research; and 

 

	 	(III)	 as background intellectual property for any academic research project. 

For the avoidance of doubt no licence is granted to or reserved by this clause 2.4(a) for any commercial use or exploitation of the Licensed
Technology. 
  

	 	(b)	 For the avoidance of doubt, academic research includes use of the Licensed Technology in the Field

  

	 	(I)	 for research into clinical patient care; 

 

	 	(II)	 to investigate, develop and provide biological materials for research purposes; and 

 

	 	(III)	 as background intellectual property for any research pursuant to EC or other government, public or charitable
research funding, and applications for the same. 

  

	 	(c)	 Except for the rights expressly set out in this Agreement, no licence is granted in respect of the Licensed
Technology or any other technology or patents of CE regardless of whether such technology or patents are dominant or subordinate to the Licensed Technology and all rights, title and interest in and to the Licensed Technology throughout the world now
or hereafter are and shall remain the exclusive property of CE, the Creators and/or the University. 

  

	2.5	 Licensing of Improvements  

 

	 	(a)	 Subject to the provisions of this Agreement, CE shall forthwith upon its creation give Licensee a written
notice describing the Licensable Improvement and shall grant the Licensee (if the Licensee so requests) a licence in respect of the Licensable Improvements with the right to sub-license, subject to clause 2.3,
to use, develop, manufacture, have manufactured, sell, supply and make available small molecule chaperones to correct the folding of
Z-alpha-1-antitrypsin only in the Field in the Territory. 

 

	 	(b)	 Any licence to a Licensable Improvement under this clause shall; 

 

	 	(I)	 be exclusive with respect to any patents or patent applications or CE Data and
non-exclusive with respect to any know-how; 

  

	 	(II)	 require that the Licensable Improvement be subject to the obligations set out in clause 3.2 with respect to any
Improvements to Know-how; 

  
 Page 5 of 29 

	 	(III)	 establish the responsibility of the Licensee for determining the scope and nature of any patent or other
intellectual property protection, such protection to be obtained at the Licensees cost; and 

  

	 	(IV)	 be effective automatically on the written acknowledgement by the Licensee to CE of a notice describing the
Licensable Improvement from CE. 

  

	 	(c)	 CE has procured written agreement from the Principal Investigator that, during the period of [####] of the
Commencement Date (i) he shall notify CE of his plans to conduct or supervise any research that may lead to the development of a Licensable Improvement and (ii) he shall assist CE in making reasonable endeavours to procure such rights as
will be required for the Improvement to become a Licensable Improvement in accordance with the agreement. 

  

	3.	 Confidentiality  

 

	3.1	 Provision of Know-how  

Upon the Licensee’s reasonable request, CE shall 
  

	 	(a)	 Arrange for the Principal Investigator to supply the Licensee with all
Know-how in his possession and that has not previously been disclosed to the Licensee and which is reasonably necessary or desirable to enable the Licensee to exercise its rights under clause 2.1. The method
of such supply shall be agreed between the Principal Investigator and the Licensee and shall fall under a consultancy agreement to be entered into between the Principal Investigator and the Licensee. 

 

	 	(b)	 Deliver up to Licensee copies (in hard copy or electronic format) of relevant documents, material or other
information related to the Licensed Technology; and 

  

	 	(c)	 Deliver to the Licensee the CE Data. 

 

	3.2	 Parties to treat Know-how as confidential 

  

	 	(a)	 The Licensee receives the Know-how as Confidential Information, whether
or not marked confidential. The Licensee shall not use the Know-how for any purpose except as expressly licensed hereby and in accordance with the provisions of this Agreement. The Licensee shall observe the
provisions of clauses 3.3 to 3.5, 3.7 and 8.5(a)(IV) in relation to the Know-how. 

  

	 	(b)	 The Licensee recognises the right of the Creators to publish academically information relating to the Know-how. CE has procured an undertaking from the Creators that neither will make any academic publication (including the publication of an abstract, article or paper in a journal or an electronic repository, or its
presentation at a conference or seminar) (each a “Publication”) relating to the Licensed Technology: 

  

	 	(I)	 within [####] of the Commencement Date [####]; and 

 

	 	(II)	 subject to 3.2(b)(I), unless he gives the Licensee written notice of not less than [####] together with an
advanced draft of the proposed publication. CE will consider in good faith any reasonable request of the Licensee to exclude from publication any information which, having regard to the Licensee’s commercialisation obligations under this
Agreement, could be damaging to the commercial interests of the Licensee. If the Licensee makes no such request, the Principal Investigator may proceed with the Publication. Nothing in this clause 3.2(b) gives the Principal Investigator the right to
disclose any Confidential Information of the Licensee in a Publication. 

  
 Page 6 of 29 

	 	(c)	 CE acknowledges that the secrecy of the Specific Know-how is of
importance, in consequence of which it places obligations of confidentiality on the Licensee as set out in this clause 3. Accordingly CE shall, and has obtained an undertaking that the Principal Investigator shall, subject to the right of
publication set out in clause 3.2(b), also treat the Specific Know-how as Confidential Information, whether or not marked confidential. 

 

	 	(d)	 CE and the Licensee recognise that a proposed publication may contain academic research results generated using
funding received under specific terms and conditions. Funders terms and conditions may conflict with the publication delay provided in clause 3.2(b)(I). The Parties agree that in the event that conflict arises between clause 3.2(b)(I) and the terms
and conditions of funders of the academic research, the latter prevail. 

  

	3.3	 Confidentiality  

The Parties agree that: 
  

	 	(a)	 Specific Know-how may not be disclosed by either Party (irrespective of
which Party is the discloser) except as expressly provided for in clause 3.2(b); 

  

	 	(b)	 no other Confidential Information disclosed by one Party (“Disclosing Party”) to the other Party
(“Recipient Party”) under this Agreement may be disclosed by the Recipient Party to any person; and 

  

	 	(c)	 clauses 3.3(a) and (b) shall not apply to Confidential Information disclosed; 

 

	 	(I)	 to employees, officers, directors, auditors, or subcontractors of the Party or the University requiring the
Confidential Information for the purposes of this Agreement or for activities set out in clause 2.4; 

  

	 	(II)	 by the Recipient Party with the prior written consent of the Disclosing Party, which consent may be given or
withheld in its absolute discretion; 

  

	 	(III)	 by the Licensee to actual or potential investors in the Licensee; 

 

	 	(IV)	 by the Licensee or Sub-Licensees to actual or potential customers or sub-licensees in so far as such disclosure is necessary to promote the sale of use of small molecule chaperones to correct the folding of Z-alpha-1-antitrypsin (or, as applicable, the sub-licensing of the Licensed Technology); 

 

	 	(V)	 if the Recipient Party is advised it is required to do so by law (including the Freedom of Information Act 2000
or Environmental Information Regulations) or stock exchange provided that CE shall use reasonable endeavours to give the Licensee advance notice of any such requirement; 

 

	 	(VI)	 by the Licensee or Sub-Licensees as may be necessary in connection with
any filing, application or request for a regulatory approval; provided, however, that reasonable measures shall be taken to assure confidential treatment of such information, to the extent such protection is available; 

 

	 	(VII)	 by the Licensee or Sub-Licensees as may be necessary or useful for
purposes of obtaining or enforcing a patent provided, however, that reasonable measures shall be taken to assure confidential treatment of such information, to the extent such protection is available; or 

 

	 	(VIII)	 if the Recipient Party is required to do so in connection with legal proceedings relating to this Agreement.

  
 Page 7 of 29 

	3.4	 Use of Confidential Information  

No Confidential Information of the Disclosing Party may be used by the Recipient Party for any purpose other than the performance of the
Recipient Party’s obligations or the exercise of the Recipient Party’s rights under this Agreement. 
  

	3.5	 Disclosing Confidential Information  

Any Party disclosing Confidential Information under clause 3.3(c)(I), (II), (Ill) or (IV) must use all reasonable endeavours to ensure
that persons receiving Confidential Information from it 
  

	 	(a)	 do not disclose or use the Confidential Information except in the circumstances permitted in clauses 3.3 and
3.4; and 

  

	 	(b)	 sign a written confidentiality undertaking on terms as least as restrictive as that binding the Recipient
Party. 

  

	3.6	 Exceptions to confidentiality obligations  

 

	 	(a)	 Clauses 3.3, 3.4 and 3.5 do not apply to Confidential Information which: 

 

	 	(I)	 is in or becomes part of the public domain other than through breach of this Agreement or an obligation of
confidence owed to the Disclosing Party; 

  

	 	(II)	 the Recipient Party can prove by contemporaneous written documentation was already known to it at the time of
disclosure by the Disclosing Party (unless that knowledge arose from disclosure of information in breach of an obligation of confidence); 

  

	 	(III)	 the Recipient Party acquires from a source other than the Disclosing Party or any employees, officers,
directors, auditors, licensees, sub-licensees, or subcontractors of the Disclosing Party where that source is entitled to disclose it; or 

 

	 	(IV)	 is independently developed by any employee or officer of the Recipient Party who had no access to the
Confidential Information and where the independent development can be proven by contemporaneous written documentation. 

  

	 	(b)	 For the avoidance of doubt the Licensee acknowledges that 

 

	 	(I)	 CE is required to inform the Creators and any others entitled to a share in CE receipts under this Agreement
(including persons other than CE employees) of the basis of CE’s calculation of the share due; and 

  

	 	(II)	 for the purpose of academic publication any Creators and any others who contributed to the creation or
development of the Licensed Technology may have to declare to the publisher and in publications that the Licensee is licensed in respect of the Licensed Technology and that income from exploitation of the Licensed Technology has or may be received.

 If a disclosure described in this clause 3.6(b)(I) or 3.6(b)(II) includes Confidential Information, CE and the academic
disclosing will be deemed to have permission to make such disclosure. 
  

	3.7	 Return of Confidential Information and survival of confidentiality obligations  

 

	 	(a)	 The Recipient Party must return promptly to the Disclosing Party if so requested all documents or other
materials containing or referring to Confidential Information which are in the Recipient Party’s possession, power or control or in the possession, power or control of persons who have received Confidential Information from the Recipient Party
under clause 3.3(c)(I), (II), (Ill) or (IV). This clause 3.7(a) shall not apply to Know-how unless termination occurs in accordance with clauses 8.2, 8.3 or 8.4. 

  
 Page 8 of 29 

	 	(b)	 The provisions of clauses 3.2 to 3.7 inclusive will survive the expiry or earlier termination (for whatever
reason) of this Agreement for a period of five years. 

  

	4.	 Payments  

  

	4.1	 Initial payment and reimbursement of costs  

The Licensee shall pay to CE 
  

	 	(a)	 the non-refundable,
non-deductible sum of [####]; and 

  

	 	(b)	 the sum of [####] (excluding VAT) in reimbursement of external receipted costs of CE in connection with
developing the Licensed Technology prior to the Commencement Date; provided however that all other fees and expenses of the lndemnitees (including legal fees) incurred prior to the Commencement Date or incidental to the preparation, negotiation, or
execution of this Agreement shall not be the responsibility of, or payable by, the Licensee (save as otherwise agreed by the Parties). 

  

	4.2	 Milestone payments  

The Licensee shall pay CE the milestone payment(s) set out in the table below when the relevant Milestone is achieved. 

 

			
	 Milestone
	  	Payment
	 [####]
	  	[####]
	 [####]
	  	[####]

 For clarity, each Milestone shall only be payable once under this Agreement; for example, there shall not be
Milestone payments for different indications requiring different INDs. In addition, CE may only invoice for a Milestone payment where the Milestone was achieved before the expiration or termination of this Agreement. 

 

	4.3	 Payment terms  

 

	 	(a)	 Payments shall be made in accordance with Schedule 3 Part A upon receipt by Licensee of a proper invoice.

  

	 	(b)	 The Licensee shall be responsible for collecting and paying to CE all payments due to CE in respect of sub-licensing. 

  

	 	(c)	 All consideration and any other monies due under this Agreement are exclusive of Value Added Tax which where
applicable shall be paid by the Licensee to CE. All payments shall: 

  

	 	(I)	 be made in pounds sterling by telegraphic transfer to the account of Cambridge Enterprise Ltd at [####];

  

	 	(II)	 in the event of a change in the national currency of the United Kingdom, be converted from pounds sterling into
the new national currency of the United Kingdom at the buying rate of such new currency as quoted by Barclays Bank pie in London on the day when such currency change comes into force; 

 

	 	(III)	 be made by the due date, failing which CE may charge reasonable debt recovery costs together with interest on
any outstanding amount on a daily basis, compounded quarterly, from the day after the due date until payment at the statutory rate in force on the due date under the Late Payment of Commercial Debts (Interest) Act 1998; and 

  
 Page 9 of 29 

	 	(IV)	 be made in full without deduction of taxes, charges or duties, including bank charges or income tax except
insofar as Licensee is required to deduct the same to comply with applicable laws. The Parties shall co-operate and take all steps reasonably and lawfully available to them to avoid deducting such taxes and to
obtain double taxation relief. If Licensee or Sub-Licensee is required to make any such deduction, it shall provide CE with such certificates or other documents as it can reasonably obtain to enable CE to
obtain appropriate relief from double taxation of the payment in question. 

  

	4.4	 Financial Reports  

 

	 	(a)	 Each payment shall be accompanied by a financial report in the form set out in Schedule 3 Part B. Such reports
shall include details of payments due in respect of sub-licensing. 

  

	4.5	 Records  

  

	 	(a)	 The Licensee shall keep at its normal place of business and cause
Sub-Licensees similarly to keep all information used to calculate payments due to CE under this Agreement. The Licensee shall keep these records separate or otherwise make them extractable easily from its
other business records and shall not dispose of them until after the sixth anniversary of their creation. 

  

	 	(b)	 The Licensee shall make such information available, on reasonable notice, for audit during business hours by
CE’s duly authorised representative for the purpose of verifying the accuracy of any report given by the Licensee to CE under this clause 4. The representative shall be required to keep confidential all information learnt during any such
inspection, and to disclose to CE only such details as may be necessary to report on the accuracy of the Licensee’s financial reports. CE shall be responsible for the representative’s professional charges unless the representative
certifies that there is an inaccuracy of more than [####] in any financial statement, in which case the Licensee shall pay the charges in respect of that inspection. The Licensee shall pay any underpayment reported by the representative within
[####] of receipt of a GE’s invoice requiring payment for the same. 

  

	 	(c)	 The Licensee shall ensure that CE has the same rights as those set out in this clause 4.5 in any sub-licence of any of the Licensed Technology granted pursuant to this Agreement. The parties shall cooperate in relation to inspection of information with Sub-Licensees and
shall nominate the same independent accountant to carry out such inspection. 

  

	4.6	 Responsibility for discharging out of payments  

CE and the University shall be responsible for discharging out of Milestone payments it receives or its own equity share in the Licensee any
and all obligations under profit share, revenue share, reward to creators and inventors or similar schemes for staff engaged in technology development. 
  

	4.7	 Equity  

  

	 	(a)	 On or before the Commencement Date, and in consideration of the licences granted by CE pursuant to this
Agreement, the Licensee shall issue and shall deliver to CE evidence of ownership of a total of [####] of its ordinary shares (the “Shares”) in the name of CE. Clause 2.1 (the grant of the Licence) shall not become effective until CE has
received a duly executed share certificate in respect of the Shares and also payment of the sums specified under clause 4.1. 

  
 Page 10 of 29 

	 	(b)	 The Licensee undertakes to CE that, at the Commencement Date, the aggregate number of the Shares will be not
less than [####] of Licensee’s issued share capital calculated on a “Fully Diluted Basis”. For purposes of this clause “Fully Diluted Basis” shall mean that the total number of issued shares shall be calculated to include
conversion of all securities which are convertible into ordinary shares, the issue of shares to be allocated to the Principal Investigator, the exercise of all the outstanding options and warrants to purchase shares (including the options to be
granted to the Principal Investigator), whether or not then exercisable, and shall assume the issuance or grant of all shares reserved for issuance pursuant to any company share option plan in effect on the date of the calculation.

  

	 	(c)	 The Licensee shall provide promptly such information as CE may reasonably request from time to time to enable
CE to assess and monitor the development of the Licensee company (and any subsidiaries) and the value of CE’s shareholding. This is likely to include an annual request of the following information for the [####] prior to the request:

  

	 	(I)	 the most recently audited company accounts (and where they are more than [####] old the most recent management
accounts also); 

  

	 	(II)	 shares, securities and options issued to University employees; and 

 

	 	(III)	 where CE shareholding is [####] or more of the issued share capital on a Fully Diluted Basis the most recent
version of the share capitalisation table, including the impact of options for management and funders. 

  

	5.	 Commercialisation obligations and reports  

 

	5.1	 Commercialisation  

The Licensee shall, having regard to clause 7.1: 
  

	 	(a)	 proceed diligently and in good faith to develop and commercially exploit the Licensed Technology;

  

	 	(b)	 use diligent efforts to execute the Development Plan (as may be amended or replaced by the Licensee from time
to time); and 

  

	 	(c)	 use all reasonable endeavours to comply with project dates and activities contemplated in the commercialisation
report submitted in accordance with clause 5.2. 

  

	5.2	 Commercialisation Reports  

Without prejudice to the generality of the Licensee’s obligations under clause 5.1, the Licensee shall send CE within [####] of each
Anniversary an updated, written commercialisation report, (which constitutes Licensee Confidential Information), covering as a minimum the [####] preceding the Anniversary and the [####] following it. The report shall include: 

 

	 	(a)	 all activities conducted under this Agreement since the Commencement Date or the date of the previous
Commercialisation Report provided under this clause 5.2; 

  

	 	(b)	 milestone progression (dates for projected and achieved Milestones); 

 

	 	(c)	 all past, current and projected activities taken or to be taken by the Licensee to exploit the Licensed
Technology; 

  

	 	(d)	 details of any sub-licences granted or rights granted to Affiliates
under the Licensed Technology during the period covered by the report; 

  

	 	(e)	 details of the commercial and public benefit which the Licensed Technology has created or stimulated; and

  
 Page 11 of 29 

	 	(f)	 details of certification of insurance cover maintained (types and levels). 

CE’s receipt or approval of any such report shall not be taken to waive or qualify the Licensee’s obligations under clause 5.1. 

 

	5.3	 Independent Expert - Reference  

If CE considers at any time during the Term that the Licensee has without legitimate reason failed to proceed diligently to develop and
commercially exploit the Licensed Technology, CE shall be entitled to refer to an independent expert the following questions: 
  

	 	(a)	 whether the Licensee has acted diligently in accordance with the criteria set out in this clause 5; and if not

  

	 	(b)	 what specific action the Licensee should have taken (“Specific Action”) in order to have acted
diligently. 

  

	5.4	 Independent Expert- appointment and decision  

The independent expert shall be appointed in accordance with the provisions of Schedule 2 and his decision shall be final and binding on the
Parties. 
  

	5.5	 GE’s right to terminate  

If the expert determines that the Licensee has failed to comply with its obligations under this clause 5, and if the Licensee fails to take the
Specific Action within [####] of the expert giving his decision in accordance with Schedule 2, CE shall be entitled, by giving, at any time within [####] after the end of that [####] period, not less than [####] notice to terminate this Agreement
and the licences granted to the Licensee under clause 2. 
 Termination in accordance with this clause 5.5 shall be CE’s sole remedy in
respect of the Licensee’s breach of this clause 5. 
  

	6.	 Intellectual property  

 

	6.1	 Patent protection  

The Licensee shall at its own cost and expense manage the filing, prosecution and maintenance of patents relating to small molecule chaperones
to correct the folding of Z- alpha-1-antitrypsin or otherwise arising from the Licensee’s exploitation of the Licensed
Technology in the Field pursuant to this Agreement (the “Licensee Patents”). 
 CE shall cooperate fully with Licensee, at the
Licensee’s expense, in the preparation, filing and prosecution of the patent applications, executing all papers and instruments or requiring inventors to execute such papers and instruments so as to enable the Licensee to apply for, to
prosecute and to maintain the Licensee Patents. 
  

	6.2	 Infringement of the Licensee Patents  

 

	 	(a)	 Each Party shall inform the other Party promptly if it becomes aware of any infringement or potential
infringement of any of the Licensee Patents in the Field. 

  

	 	(b)	 Subject to clause 6.2(c), the Licensee shall be entitled to take legal or other action against any third party
to enforce the Licensee Patents at its sole expense. 

  

	 	(c)	 Before starting legal action in accordance with sub-clause 6.2(b), the
Licensee shall consult CE and take its views into account about the advisability of the action or settlement, its effect on the University and CE’s reputation and good name, the public interest and how the action should be conducted.

  
 Page 12 of 29 

	6.3	 Infringement of third party rights  

 

	 	(a)	 If any warning letter or other notice of infringement is received by a Party, or legal action is brought
against a Party, alleging infringement of third party rights in the use of the Licensed Technology, that Party shall promptly provide full details to the other Party, and the Parties shall discuss the best way to respond. 

 

	 	(b)	 The Licensee shall have the right but not the obligation to defend such action and shall have the right to
settle with such third party, provided that if any action or proposed settlement involves the making of any statement, express or implied, concerning the confidentiality of the Know-how, the consent of CE (not
to be unreasonably withheld, delayed or conditioned) must be obtained before taking such action or making such settlement. 

  

	7.	 Warranties and liability  

 

	7.1	 Status of Licensed Technology  

The Licensee acknowledges that the Licensed Technology is at an early stage of development, that it is provided “as is” and specific
results cannot be guaranteed. The Licensee shall be exclusively responsible for the technical and commercial development of the Licensed Technology. The Parties accept that, given the nature of all scientific research and development work in respect
of the Licensed Technology, the Development Plan set out in Schedule 4 may not be achievable within the timescales or within the budgets envisaged or at all. As such the Licensee makes no warranty that any or all of the scientific research and
development work envisaged will be achieved. 
  

	7.2	 No representations or warranties  

 

	 	(a)	 The Licensee acknowledges that CE has not performed any searches or investigations into the existence of any
third party rights, which may affect any of the Licensed Technology and that in entering into this Agreement it does not do so in reliance on (and shall have no remedy in respect of) any representation, warranty or other provision, except as
expressly provided in this clause, in which case any remedy shall be limited to an action for breach of contract under the terms of this Agreement. 

  

	 	(b)	 CE warrants that: 

  

	 	(I)	 with the exception of the rights reserved in clause 2.4(a), the University and the Creators have granted a
licence to their rights to CE in the Know-how as required for CE to license said Know-how to the Licensee in accordance with this Agreement; 

 

	 	(II)	 under the terms and conditions of the service agreement with [####], CE owns the CE Data;

  

	 	(III)	 the Licensed Technology has not been licensed to any person, charged or encumbered; 

 

	 	(IV)	 to the best of its knowledge and belief the execution and delivery of this Agreement and the performance of the
transactions contemplated hereunder have been duly authorized by all necessary corporate actions; and 

  

	 	(V)	 to the best of its knowledge and belief the performance by CE of any of its obligations hereunder does not
conflict with, or constitute a breach or a violation of any other contractual obligation to which it is a party. 

  
 Page 13 of 29 

	 	(c)	 Except as provided by clause 7.2(b) CE makes no representations or warranties of any kind, express or implied,
concerning the Licensed Technology including: 

  

	 	(I)	 as to the satisfactory quality or fitness for a particular purpose; or 

 

	 	(II)	 as to the absence of latent or other defects, whether or not discoverable; or 

 

	 	(III)	 that the exploitation of the Licensed Technology or any Licensed Product will not infringe any patents or other
intellectual property rights of a third party. 

 All conditions, warranties or other terms implied by statute or common
law are excluded from this Agreement to the fullest extent permitted by law. 
  

	7.3	 Liability and indemnity  

 

	 	(a)	 The limitations and exclusions in this Agreement shall not apply in respect of claims for personal injury or
death caused by negligence of the lndemnitees or the Licensee or in respect of fraud or fraudulent misrepresentation. 

  

	 	(b)	 In respect of any damages or expenses of whatsoever nature and howsoever arising (including in contract, tort,
negligence or for breach of statutory duty or misrepresentation) in connection with any use of the Licensed Technology or otherwise in connection with this Agreement or any relationships established by it: 

 

	 	(I)	 the aggregate liability of the lndemnitees and the Licensee shall be limited to the total income which CE has
received from the Licensee during the [####] preceding the year of the Term in which the liability arises or [####] whichever shall be the higher; and 

  

	 	(II)	 in no circumstances shall the lndemnitees or Licensee be under any liability to each other (whether in
contract, tort (including negligence), breach of statutory duty, restitution or otherwise) for any indirect, incidental or consequential losses including; 

  

	 	I)	 pure economic loss, loss of profits, loss of business, loss of revenue, loss of contract, loss or depletion of
goodwill and/or business opportunity, loss of anticipated earnings or savings or like loss; or 

  

	 	II)	 loss of use or value of any data or software; or 

 

	 	III)	 wasted management, operational or other time; or 

 

	 	IV)	 any special, indirect or consequential losses. 

 

	 	(c)	 Notwithstanding anything else in this Agreement the Licensee shall indemnify the lndemnitees in full against
all demands, claims, judgements and liability (howsoever arising and whether in contract, tort, negligence or for breach of statutory duty or misrepresentation) for damages, costs, expenses or any other loss of whatsoever nature including damage to
property, financial loss, personal injury and death, which is asserted in any claim or threatened claim by any third party (that is to say not any of the lndemnitees) against all or any of the lndemnitees and which relates to or arises from use by
the Licensee or any Sub-Licensee or any end user of the whole or any part of the Licensed Technology. 

The indemnity also extends to the lndemnitees’ reasonable legal and professional fees and any reasonable expenses incurred in dealing with
any such third party claim. Nothing in this sub-clause shall prevent the Licensee recovering from CE, (or setting off against sums otherwise due to CE under this Agreement), subject to the exclusions and
limitations set out this Agreement, damages awarded by a competent court to the Licensee for default by CE of any of its contractual obligations under this Agreement. 

  
 Page 14 of 29 

 8. Duration and termination  

 

	8.1	 Term  

This Agreement, and the licences granted hereunder, shall come into effect on the Commencement Date and, unless terminated earlier in
accordance with this clause 8, shall continue in force for 20 years (the “Term”) and on such date this Agreement and the licences granted hereunder shall terminate automatically by expiry and the Licensee shall be free to use the Know-how without restriction. 
  

	8.2	 Early termination by the Licensee  

The Licensee may terminate this Agreement at any time on [####] notice in writing to CE. 

 

	8.3	 Early termination by CE  

CE may terminate this Agreement in either of the following cases as provided in clause 5.5. 

 

	8.4	 Early termination by either Party  

Without prejudice to any other right or remedy, either Party may by written notice to the other Party terminate this Agreement at any time, if
any of the following events occur: 
  

	 	(a)	 the other Party has materially breached this Agreement (and for the avoidance of doubt non-payment without proper cause by the Licensee under clause 4 shall be deemed a material breach) and, in case of a remediable breach other than a persistent breach, has failed to remedy that breach within [####]
of the date of service of a written notice from the other Party specifying the breach and requiring that it be remedied; 

  

	 	(b)	 the other Party ceases to carry on business, is unable to pay its debts when they fall due, is declared
bankrupt, or an order is made or a resolution passed for the winding up of that other Party or for the appointment of an administrator, receiver, liquidator or manager of that other Party; or 

 

	 	(c)	 if the force majeure event as defined in clause 10.1 continues for longer than [####]. 

 

	8.5	 Consequences of termination  

 

	 	(a)	 Upon termination of this Agreement for any reason otherwise than in accordance with clause 8.1:

  

	 	(I)	 the Licensee and Sub-Licensees shall be entitled to sell, use or
otherwise dispose of any unsold or unused stocks of products developed under the Licensed Technology for a period of [####] following the date of termination; 

 

	 	(II)	 subject to paragraph 8.5(a)(I) above, the Licensee shall no longer be licensed to use or otherwise exploit in
any way either directly or indirectly any of the Licensed Technology; 

  

	 	(III)	 subject to paragraph 8.5(a)(I) above, the Licensee shall consent to the cancellation of any formal licence
granted to it or of any registration of it in any register in relation to any of the Licensed Technology; 

  

	 	(IV)	 each Party shall return to the other (or destroy at the other’s request) all Confidential Information
disclosed to it by the other and all materials containing any Confidential Information in its possession or control (including, in the case of the Licensee, in the possession or control of its Sub-Licensees);
and 

  
 Page 15 of 29 

	 	(V)	 upon CE’s request (if Licensee has not terminated pursuant to clause 8.4) the Licensee shall (to the
extent it is able having regard to obligations to third parties) notify CE of the nature of any materials, details of all technical processes, manufacturing data, improvements, information, know-how and
results relating to the Licensed Technology created or developed by the Licensee or sub-contractors or Sub-Licensees that may be reasonably required by CE to arrange for
the further exploitation of the Licensed Technology. The Parties shall negotiate in good faith without delay for up to [####] the terms of an agreement between them on reasonable commercial terms to enable CE to arrange for the further exploitation
of the Licensed Technology including any patents as they exist at the date of termination. 

  

	 	(b)	 If the Parties are unable to agree the terms of an agreement as described in clause 8.5(a)(V) CE may initiate
the procedure in clause 9. 

  

	 	(c)	 The expiry or termination of this Agreement does not affect any rights or obligations of either Party which
have arisen or accrued up to and including the date of expiry or termination including the right to payment under this Agreement. 

  

	 	(d)	 Clauses 2.3(d), 2.4, 3.2(a), 3.3 to 3.7, 4 (in respect of payments due on or before termination or under clause
8.5(a)(I)), 7, 8.5, 9 and 10 survive expiry or termination (for whatever reason). 

  

	9.	 Dispute resolution  

The Parties agree that should any dispute arise between them in relation to this Agreement (other than under clause 5), they shall meet as soon
as practicable and negotiate in good faith with a view to resolving the dispute. 
 If the Parties are unable to settle any dispute by
negotiation within [####] the Parties will attempt to settle it by mediation in accordance with the Centre for Effective Dispute Resolution (CEDR) Model Mediation Procedure. 

To initiate a mediation a Party must give notice in writing to the other Party, requesting a mediation in accordance with this clause 9. 

Nothing in this clause 9 shall prevent either Party from applying for injunctive relief to restrain any actual or potential breach of this
Agreement. 
  

	10.	 General  

  

	10.1	 Force majeure  

 

	 	(a)	 Notwithstanding any other provision of this Agreement, no Party need act if it is impossible to act due to
force majeure, meaning any cause beyond its control (including war, riot, natural disaster or law taking effect after the date of this Agreement). A Party affected by force majeure agrees to notify the other Party promptly after it determines that
it is unable to act. 

  

	 	(b)	 A Party has no responsibility or liability for any loss or expense suffered or incurred by the other Party as a
result of its not acting for so long as the force majeure under clause 10.1 continues. However, the non-performing Party agrees to make reasonable efforts to avoid or remove the circumstances giving rise to
the force majeure and agrees to continue performance under this Agreement promptly when they are removed. 

  
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	10.2	 Assignment  

  

	 	(a)	 Save as provided by clause 10.2(b) and 10.2(c) neither Party may assign, transfer, charge or deal in any other
manner with this Agreement nor purport to do so without the prior written consent of the other Party. 

  

	 	(b)	 CE may assign the whole or any of its rights and obligations under this Agreement to any person responsible for
the management of the University’s intellectual property provided that (i) consent of the Licensee shall be required, not to be unreasonably withheld or delayed, to any assignment to an entity not wholly owned or controlled by the
University, and (ii) CE’s assignee shall undertake to be bound by and perform CE’s obligations under this Agreement. CE shall notify the Licensee of any assignment under this Agreement. 

 

	 	(c)	 The Licensee may assign all its rights and obligations under this Agreement where the assignment is connected
with the transfer of all or substantially all of the Licensee’s assets to a single purchaser and provided such purchaser undertakes to CE to be bound by and perform the obligations of the Licensee under this Agreement and is capable of
performing such obligations. The Licensee shall notify CE of any such assignment. 

  

	10.3	 Waiver  

A provision of this Agreement or any right created under it cannot be waived or varied except in writing signed by the Parties. 

 

	10.4	 Invalid clauses  

If the whole or any part of a provision of this Agreement is void, unenforceable or illegal in a jurisdiction it is severed for that
jurisdiction. The remainder of this Agreement has full force and effect and the validity or enforceability of that provision in any other jurisdiction is not affected. This clause has no effect if the severance alters the basic nature of this
Agreement or is contrary to public policy. 
  

	10.5	 No agency  

Nothing in this Agreement shall be construed as creating any agency, partnership or other form of joint enterprise between the Parties and
neither Party has the authority to act for or bind the other Party in any way. 
  

	10.6	 Notices  

Any notice to be given under this Agreement shall be in writing and delivered by hand, prepaid registered post to the other Party at the
address set out below or to such other address as either Party may specify in writing to the other. 
  

			
	 Notices to CE
	  	Director, Cambridge Enterprise Ltd,
		  	University of Cambridge
		  	Hauser Forum
		  	3 Charles Babbage Road
		  	Cambridge
		  	CB3 0GT
		  	UK
		  	Fax number: [####]
		
	 Notices to Licensee
	  	Director, Z Factor Ltd
		  	3 Burlington Gardens
		  	London
		  	W1S 3EP
		  	UK

 Notices are deemed to have been given: 
  

	 	(a)	 if delivered by hand, at the time of the delivery unless delivered after 5pm in the place of receipt or on a non-business day, in which case the notice is deemed to have been given at 9am the next business day; and 

  
 Page 17 of 29 

	 	(b)	 if sent by pre-paid first class post from within the United Kingdom,
three business days after posting (or seven business days if posted from outside the United Kingdom). 

  

	10.7	 Law and jurisdiction  

This Agreement and any documents to be entered into pursuant to it shall be governed by and construed in accordance with English law and each
Party irrevocably submits to the exclusive jurisdiction of the courts of England over any claim or matter arising under or in connection with this Agreement and the documents entered into pursuant to it except that a Party may seek an interim
injunction for enforcement of intellectual property rights as described in clause 9 in any court of competent jurisdiction. 
  

	10.8	 Further action  

Each Party (at the cost of the requesting Party) agrees to execute, acknowledge and deliver such further instruments, and do all further
similar acts, as may be reasonably necessary or reasonably appropriate to carry out the purposes and intent of this Agreement. 
  

	10.9	 Announcements  

A Party may not make press or other announcements or releases relating to this Agreement or the transactions the subject of this Agreement
without the approval of the other Party to the form and manner of the announcement or release unless and to the extent that the announcement or release: 
  

	 	(a)	 is required to be made by law or by a stock exchange; 

 

	 	(b)	 is made in a report to funders or in an annual report of CE and does not disclose Confidential Information; or

  

	 	(c)	 falls within the terms of clause 3.6(b). 

 

	10.10	 Entire agreement  

This Agreement the other agreements relating to access to intellectual property and collaboration entered into on Commencement Date constitutes
the entire agreement and understanding of the Parties and supersedes all negotiations, understandings or previous agreement between the Parties relating to the subject matter of this Agreement. Nothing in this Agreement, including this clause and
clause 7.2, shall operate to limit or exclude liability for fraud or fraudulent misrepresentation. 
  

	10.11	 Third party rights  

The University, any University wholly owned subsidiary, the University’s employees and students, the Creators and the Principal
Investigator may enforce those terms of this Agreement which expressly confer rights on them, subject to and in accordance with the Contracts (Rights of Third Parties) Act 1999. Save as aforesaid no term of this Agreement shall be enforceable under
that Act by a person who is not a party to this Agreement, but this shall not affect any right or remedy of any third party which exists or is available other than under that Act. Notwithstanding that any term of this Agreement may be or become
enforceable under that Act by a person which is not a party to it, this Agreement may be amended in any respect, or suspended, cancelled or terminated by agreement in writing between the Parties, in each case without the consent of such third party.

  

	10.12	 Export Control Regulations  

 

	 	(a)	 “Export Control Regulations” mean any United Nations trade sanctions or EU or UK legislation or
regulation, from time to time in force, which impose arms embargoes or control the export from the United Kingdom of goods, technology or software, including weapons of mass destruction and arms, military, paramilitary and security equipment and dual-use items (items designed for civil use but which can be used for military purposes) and certain drugs and chemicals. 

  
 Page 18 of 29 

	 	(b)	 The Licensee shall ensure that, in using the Licensed Technology, it shall not and nor shall its employees or sub-contractors or any Sub-Licensee directly or indirectly breach or compromise compliance with any Export Control Regulations. 

 

	10.13	 Non-use of names and marking of Licensed Products 

  

	 	(a)	 Consent is not needed to state that CE has granted the Licensee a licence to use the Licensed Technology to
make and supply Licensed Products. In all other cases the Licensee shall not use and shall ensure that Sub-Licensees do not use (including in any advertising, promotional or sales materials) the name, any
adaptation of the name, any logo, trademark or other device of 

  

	 	(I)	 the “University of Cambridge” unless it has first obtained in each case the University’s prior
written consent; 

  

	 	(II)	 “Cambridge Enterprise Limited” or of the Creators or Principal Investigator unless it has first
obtained in each case CE’s prior written consent. 

  

	10.14	 Insurance  

Without prejudice to its obligations under clause 7.3(c) the Licensee shall take out with a reputable insurance company within [####] of the
Commencement Date and maintain at all times during the Term public and product liability and professional indemnity insurance including against all loss of and damage to property (whether real personal or intellectual) and injury to persons
including death arising out of or in connection with this Agreement and the Licensee’s and Sub-Licensees’ use of the Licensed Technology and use, sale of or any other dealing in any of the Licensed
Products. Such insurances shall be at a level which reflects the scale of activity in relation to the Licensed Technology, not exclude litigation in England, and include an indemnity to principals clause in favour of CE and the University. Subject
thereto, cover may be limited in respect of one claim provided that such limit must be at least [####] for public and product liability and [####] for professional indemnity insurance. Professional indemnity insurance shall continue to be maintained
for a further [####] from the end of the Term. 
  

	10.15	 Counterparts  

This Agreement may be signed in counterparts and each counterpart shall constitute an original of the Agreement. 

 

	10.16	 Legal Compliance  

The Licensee shall comply with the following (and any amendment or re-enactment): all statutes, bye
laws, regulations, codes of practice, European and other directives and provisions and all professional rules and standards to be observed and performed in connection with the exploitation of the Licensed Technology. 

  
 Page 19 of 29 

 AGREED by the parties through their authorised signatories:- 

 

					
	For and on behalf of	 		  	For and on behalf of
	CAMBRIDGE ENTERPRISE LIMITED	 		  	Z FACTOR LIMITED
			
	 /s/J.M Grimshaw
	 		  	 /s/ Francesco De Rubertis

	Signed	 		  	Signed
			
	 J.M. Grimshaw
	 	                                	  	 Francesco De Rubertis

	Print name	 		  	Print name
			
	 Head of Physical Sciences
	 		  	 Director

	Title	 		  	Title
			
	 3 Feb 2015
	 		  	 04/02/15

	Date	 		  	Date

  
 Page 20 of 29 

 SCHEDULE 1 

[####] 

  
 Page 21 of 29 

 SCHEDULE 2 

[####] 

  
 Page 22 of 29 

 SCHEDULE 3 

[####] 

  
 Page 23 of 29 

 Part A: [####] 

  
 Page 24 of 29 

 [####] 

  
 Page 25 of 29 

 Part B: [####] 

[####] 

  
 Page 26 of 29 

 SCHEDULE 4 

[####] 

  
 Page 27 of 29 

 Director 
 Z
Factor Limited 
 Moneta Building Babraham Research Campus 

Babraham 
 Cambridge 

CB22 3AT 
 2017 

Variation of the terms of the Licence between Z Factor Limited (“ZF”) and Cambridge Enterprise Limited (“CE”), with an effective date of
4th February 2015, (the “Agreement”). 
 CE Reference: A10157 

ZF and CE wish to vary the terms of the Agreement, a copy of which is attached to Schedule 1 of this letter, as follows: 

Clause 4.2 of the Agreement will be deleted and replaced with the following: 

4.2 Milestone payments 

The Licensee shall pay CE the milestone payment(s) set out in the table below when the relevant Milestone is achieved. 

 

			
	Milestone	  	Payment
	[####]	  	[####]
	[####]	  	[####]
	[####]	  	[####]

 For clarity, each Milestone shall only be payable once under this Agreement; for example, there shall not be
Milestone payments for different indications requiring different INDs. In addition, CE may only invoice for a Milestone payment where the Milestone was achieved before the expiration or termination of this Agreement. 

Save as amended in this Letter of Variation, all other terms, obligations and rights of the parties under the Agreement shall remain in full force and effect.

 This Letter of Variation shall be governed by and construed in accordance with English law and the parties hereto irrevocably submit to the exclusive
jurisdiction of the courts of England over any claim or matter arising under or in connection with this Letter of Variation. 
 This Letter of Variation may
be signed in counterparts exchanged in pdf format and each counterpart shall constitute an original of this Letter of Variation and all counterparts together shall constitute one agreement. 

 Signed by: /s/ P. Seabright 

Name: Dr. P. Seabright 
 Position: Deputy Director 

On behalf of Cambridge Enterprise Limited 
 Date: 2 March
2017 
 Signed by: /s/ D.J. Grainger 
 Name: Dr. DJ
Grainger 
 Position: Director 
 On behalf of Cambridge
Enterprise Limited 
 Date: 2 March 2017 

 Schedule 1 begins on next page

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