Document:

<PAGE>

                               NORSTAR GROUP, INC.

                                STOCK OPTION PLAN

1.  Purpose of Plan.

         This 2000 Stock Option Plan (the "Plan") is designed to assist NorStar
Group, Inc. (the "Company") in attracting and retaining highly qualified persons
as employees of the Company and its Subsidiaries and to provide such key
employees with incentives to contribute to the growth and development of the
business of the Company.

         This Plan will be effected through the granting of stock options on the
terms and conditions hereinafter provided, which options are intended to qualify
as "incentive stock options" within the meaning of section 422(b) of the
Internal Revenue Code of 1986, as amended.

2.  Definitions.

         Unless the context otherwise indicates, the following terms have the
following meanings:

         "Board" means the Board of Directors of the Company.

         "Code" means the Internal Revenue Code of 1986, as the same may from
time to time be amended.

         "Committee" means a committee consisting of at least three (3)
Disinterested Persons appointed by the Board to administer the Plan and to
perform the functions set forth herein.

         "Common Stock" means the Common Stock of the Company.

         "Designated Beneficiary" means the person designated by an optionee to
be entitled on his death to any remaining rights arising out of an option, such
designation to be made by written notice from the optionee to the Company in
accordance with such regulations as the Committee may create.

         "Disinterested Person" means a person (within the meaning of Rule 16b-3
under the Exchange Act) who at the time he exercises discretion as a member of
the Committee is not and at any time within one (1) year prior thereto has not
been eligible for selection (within the meaning of Rule 16b-3 of the Exchange
Act) as a person to whom shares of Common Stock may be allocated or to whom
stock options or stock appreciation rights may be granted pursuant to

                                        1
<PAGE>

this Plan or any other plan of the Company or any other Subsidiary entitling
participants therein to acquire stock, stock options or stock appreciation
rights of the Company or any Subsidiary.

         "Employee" means any employee (including any officer) of the Company or
any subsidiary of the Company.

         "Exchange Act" means the Securities Exchange Act of 1934, as amended.

         "Fair Market Value" means the fair market value of the shares of Common
Stock ("Fair Market Value") shall be the last closing sale price on the
principal exchange on which the Common Stock is traded; or if not traded on any
exchange, shall then be the average of the last closing bid and asked price as
reported for the shares on the Over-the-Counter Bulletin Board ("OTCBB") or on
the last date preceding such date on which a sale was reported.

         "Incentive Stock Options" means stock options which constitute
incentive stock options within the meaning of Section 422(b), or any successor
section, of the Code having the provisions specified in the Plan for such
incentive stock options.

         "Parent" means "parent corporation" as defined in Section 425(e), or
any successor section, of the Code.

         "Stock Option Agreement" means a stock option agreement entered into
pursuant to the Plan substantially in the form of Exhibit A hereto.

         "Subsidiary" means "subsidiary corporation" as defined in Section 425
(f), or any successor section of the Code.

         "Ten Percent Stockholder" means any person who, immediately after any
option is granted to such person, owns within the meaning of Section 422 (b)(6),
or any successor section, of the Code more than 10% of the total combined voting
power of all classes of stock of the Company, its parent, if any, or its
Subsidiaries.

3.  Stock Subject to Plan

         The shares to be issued upon exercise of the options granted under the
Plan shall be Common Stock. The maximum number of shares of Common Stock for
which options may be granted under the Plan shall be 2,000,000 shares (subject
to adjustment as provided in Section 9 hereof). If any option granted under the
Plan shall expire or terminate for any reason whatsoever without having been
exercised in full, the unpurchased shares of Common Stock previously subject to
such option shall become available for new options.

                                        2
<PAGE>

4.  Administration.

         (a) The Plan shall be administered by the Committee. The Board shall
annually appoint the members of the Committee at the annual organizing meeting
of the Board. Each member of the Committee shall be a Disinterested Person.

         (b) The Board shall fill all vacancies on the Committee and may remove
any member of the Committee at any time with or without cause. The Committee
shall select its own chairman and shall adopt, alter or repeal such rules and
procedures as it may deem proper and shall hold its meetings at such times and
places as it may determine. The Committee shall keep minutes of its meetings.
Action by a majority of the Committee members present at any meeting at which a
quorum is present, or action approved in writing by all members of the Committee
without a meeting, shall constitute the acts of the Committee.

         (c) Subject to the provisions of the Plan, the Committee shall have the
full and final authority to (i) determine the eligible employees of the Company
and its Subsidiaries to whom, and the times at which, options shall be granted
and the number of shares subject to each option; (ii) prescribe, amend and
rescind rules and regulations relating to the Plan; (iii) determine the
provisions of options granted under the Plan (which need not be identical) and,
with the consent of the holder thereof, amend or modify any option; (iv)
interpret the Plan and the respective options; and (v) make all other
determinations necessary or advisable for administering the Plan. All
determinations and interpretations by the Committee shall be binding upon all
parties. No member of the Committee or the Board shall be liable for any action
or determination made in good faith in respect of the Plan or any option granted
under it.

         (d) The provisions of this Section 4 shall survive any termination of
the Plan.

5.  Eligibility for Award of Options.

         (a) Options may be granted only to officers and other key employees of
the Company and its Subsidiaries. Any reference in the Plan to "employment by
the Company" shall also be deemed to include employment by any Subsidiary of the
Company. Determination by the Committee or the Board as to who are eligible
employees shall be conclusive.

         (b) A person who is a director of the Company shall not be considered
an officer or employee for the purpose of the Plan solely because he or she is a
director. However, a person who otherwise is an eligible officer or employee
shall not be disqualified by virtue of being a director of the Company or any
Subsidiary.

         (c) More than one option may be granted to any eligible employee.

                                        3
<PAGE>

6.  Option Price.

         The purchase price of the Common Stock under each option shall be
determined by the Committee. The purchase price shall be at least 100 percent
(100%) of the Fair Market Value of the Common Stock on the date of grant of
option. The purchase price under an option granted to an officer or employee who
is a Ten Percent Stockholder shall be at least 110% of the Fair Market Value of
the Common Stock on the date of the grant of the option.

7.  Annual Limitation on Grants to One Officer or Employee.

         No option shall be granted during any calendar year to any individual
under the Plan if the aggregate fair market value (as of the time the option is
granted) of the Common Stock with respect to which incentive stock options are
exercisable for the first time by such individual during any calendar year
(under the Plan and any other plan of the Company, its Parent, if any, and its
Subsidiaries) exceeds 10% of EBITDA.

8.  Terms and Exercise of Option.

         (a) Maximum Ten-Year Termination Date. Each option shall expire no
later than ten years after the date on which it shall have been granted, but the
Committee in its discretion may prescribe a shorter period for any individual
option or options. Any option granted to a person who is a Ten Percent
Stockholder shall terminate no later than five years after the date on which the
option was granted. The date of termination pursuant to this paragraph is
referred to hereinafter as the "termination date of the option."

         (b) Vesting. Options shall be exercisable at such times and in such
installments, if any, as the Committee may determine. In the event any option is
exercisable in installments, any shares which may be purchased during any year
or other period which are not purchased during such year or other period may be
purchased at any time or from time to time during any subsequent year or period
during the term of the option unless otherwise provided in the Stock Option
Agreement.

         (c) Means of Exercise of Option. An option shall be exercised by
written notice to the Secretary or Treasurer of the Company at its then
principal office which is received not later than 5:00 p.m. of the expiration
date. The notice shall specify the number of shares as to which the option is
being exercised and shall be accompanied by payment in full of the purchase
price for such shares. An optionee at his discretion may, in lieu of cash
payment, deliver Common Stock already owned, with a Fair Market Value (on the
date of exercise) equal to the purchase price for the shares being acquired
pursuant to the exercise of the option, as payment for the exercise of any
option. In the event an option is being exercised in whole or in part, pursuant
to Section 8 (f) or (g) hereof by any person other than the optionee, a notice
of election shall be accompanied by proof satisfactory to the Company of the
rights of such person to exercise said option. An optionee shall not, by virtue
of the granting of an option, be entitled to any rights of a

                                        4
<PAGE>

shareholder in the Company and he or she shall not be considered a record holder
of shares purchased by him until the date on which he shall actually be recorded
as the holder of such shares upon the stock records of the Company. The Company
shall not be required to pay to the person exercising the option the cash
equivalent of any fractional share interest unless so determined by the
Committee.

         (d) Options are Nontransferable. No option may be transferred by the
optionee (except in connection with death or disability as provided in Sections
8(f) and (g)).

         (e) Options Lapse Three Months after Termination of Employment. In the
event of the termination of an optionee's employment by the Company and its
Subsidiaries at any time for any reason (excluding disability or death), the
optionee's options and all rights thereunder shall expire three months after the
date of termination of employment. The option shall be exercisable by the
optionee at any time within months, but only to the extent exercisable by the
optionee on the date of termination of his or her employment.

         (f) Option Exercisable Six Months After Termination in Event of
Disability. In the event the optionee is permanently and totally disabled
(within the meaning of Section 105(d)(4), or any successor section, of the
Code), the optionee's option and all rights thereunder shall expire six months
after the date of termination of employment. The option shall be exercisable by
the optionee (or the optionee's legal representative) at any time within such
six months.

         (g) Option Exercisable Six Months after Date of Death. If an optionee
shall die while in the employ of the Company or any of its Subsidiaries, his
option may be exercised by his designated beneficiaries (or if none have been
effectively designated, by his executor, administrator or the person to whom
rights under his option shall pass by way of his will or by the laws of descent
and distribution) at any time within six (6) months after date of his death, but
only to the extent exercisable by the optionee at his death. The option shall
expire six months after the date of the optionee's death.

         (h) No Right to Continued Employment. Nothing in the Plan or in any
option granted pursuant hereto shall confer on any individual any right to
continue in the employ of the Company or any of its Subsidiaries or prevent or
interfere in any way with the right of the Company or its Subsidiaries to
terminate the optionee's employment at any time, with or without cause.

         (i) Options Must be Evidenced by Writing. Each option granted pursuant
to the Plan shall be evidenced by a written Stock Option Agreement, duly
executed by the Company and the optionee, in such form and containing such
provisions as the Committee or Board may from time to time authorize or approve.

                                        5
<PAGE>

9.  Adjustments.

         The Stock Option Agreement shall contain appropriate provisions for the
adjustment of the kind and number of shares subject to each outstanding option,
and for the adjustment of the exercise price per share, in the event of any
changes in the outstanding Common Stock of the Company by reason of stock
dividends, stock splits, recapitalization, reorganizations, mergers,
consolidations, combinations or exchanges of shares, and the like. In the event
of any such change or changes in the outstanding Common Stock, and as often as
the same shall occur, the kind and aggregate number of shares available under
the Plan shall be appropriately adjusted by the Committee or Board, whose
determination shall be binding and conclusive.

10.  Amendment and Termination.

         (a) Unless the Plan shall have been sooner terminated as provided
herein, it shall terminate on, and no option shall be granted thereunder after
April 17, 2010. The Board may at any time prior to that date alter, suspend or
terminate the Plan as it may deem advisable, except that it may not without
further shareholder approval: (i) increase the maximum number of shares subject
to the Plan (except for changes pursuant to Section 9); (ii) extend the period
during which options may be granted or exercised; or (iii) make any other
changes unless the Board determines that the change would not materially
increase the cost of the Plan to the Company. Except as otherwise hereinafter
provided, no alteration, suspension or termination of the Plan may, without the
consent of the employee to whom any option shall have theretofore been granted
(or the person or persons entitled to exercise such option under Section 8(f) or
(g) of the Plan), terminate his option or adversely affect his rights
thereunder.

         (b) Anything herein to the contrary notwithstanding, in the event that
the Board shall at any time declare it advisable to do so in connection with any
proposed sale or conveyance of all or substantially all of the assets of the
Company or of any proposed consolidation or merger of the Company, the Company
may give written notice to the holder of any option that his option may be
exercised only within thirty (30) days after the date of such notice but not
thereafter, and all rights under said option which shall have not been so
exercised shall terminate at the expiration of such thirty (30) days, provided
that the proposed sale, conveyance, consolidation or merger to which such notice
shall relate shall be consummated within six (6) months after the date of such
notice. In the event such notice shall have been given, any such option may be
exercised either in whole or in part notwithstanding the vested period required
under the terms of the option for the exercise thereof. If such proposed sale,
conveyance, consolidation or merger shall not be consummated within said time
period, no unexercised rights under any option shall be affected by such notice
except that such option may not be exercised between the date of expiration of
such thirty (30) days and the date of the expiration of such six (6) months.

                                        6
<PAGE>

11.  Indemnification.

         Any member of the Committee or the Board who is made, or threatened to
be made, a party to any action or proceeding, whether civil or criminal, by
reason of the fact that the member is or was a member is or was a member of the
Committee or the Board insofar as it relates to the Plan shall be indemnified by
the Company, and the Company may advance his related expenses, to the full
extent permitted by law or to any greater extent as provided in the Company's
Certificate of Incorporation or By-Laws or in any agreement between the Company
and the member.

12.  Effective Date of the Plan.

         The Plan shall become effective on, and options may be granted
thereunder after April 17, 2000, provided, however, that if the Plan shall not
be approved by the holders of a majority of the outstanding voting stock of the
Company within 12 months of said date, the Plan and all options granted
thereunder shall be and become null and void, and provided, further, that no
options granted by the Commission may be exercised prior to the approval of the
Plan by shareholders.

13.  Expenses.

         The Company shall pay all fees and expenses incurred in connection with
the establishment and administration of the Plan.

14.  Government Regulations.  Registration and Listing of Stock.

         (a) The Plan, and the grant and exercise of options thereunder, and the
Company's obligation to sell and deliver stock under such options, shall be
subject to all applicable federal and state laws, rules and regulations and to
such approvals by any regulatory or governmental agency as may be required.

         (b) Unless a registration statement under the Securities Act of 1933
and the applicable rules and regulations thereunder (collectively the "Act") is
then in effect with respect to shares issued upon exercise of any option (which
registration shall not be required), the Company shall require that the offer
and sale of such shares be exempt from the registration provisions of said act.
In furtherance of such exemption, the Company may require, as a condition
precedent to the exercise of any option, that the person exercising the option
give to the Company a written representation and undertaking, satisfactory in
the form and substance to the Company, that he or she is acquiring the shares
for his or her own account for investment and not with a view to the
distribution or resale thereof and otherwise establish to the Company's
satisfaction that the offer or sale of the shares issuable upon the exercise of
the option will not constitute or result in any breach or violation of the Act
or any similar state act or statute or any rules or regulations thereunder. In
the event a Registration Statement under the Act is not then in effect with
respect to the shares of Common Stock issued upon exercise of an option, the
Company shall place upon any stock certificate an appropriate legend referring
to the restrictions on disposition under the Act.

                                        7
<PAGE>

         (c) In the event the class of shares issuable upon the exercise of any
option is listed on any national securities exchange, the Company shall not be
required to issue or deliver any certificate for shares upon the exercise of any
options prior to the listing of the shares so issuable on such national
securities exchange and prior to the registration of the same under the Exchange
Act or any similar act or statute.

                                       NORSTAR GROUP, INC.

                                       By: /s/ Harry DiFrancesco
                                           --------------------------------
                                           Harry DiFrancesco, President

Attest:

/s/ Andrew Peck
---------------------------
Andrew Peck, Secretary

                                        8<PAGE>   1
                                                                     EXHIBIT 4.1

                                NEORX CORPORATION

                            SHARE PURCHASE AGREEMENT

        SHARE PURCHASE AGREEMENT, dated as of April __, 2000, between NeoRx
Corporation, a Washington corporation (the "Company"), and the purchaser listed
on Schedule A attached hereto (the "Purchaser").

1.      AUTHORIZATION OF SALE OF THE SHARES

        Subject to the terms and conditions of this Agreement, the Company has
authorized the issuance and sale of up to 4,000,000 shares (the "Shares") of
common stock, par value $0.02 per share (the "Common Stock"), of the Company
(the "Offering.").

2.      AGREEMENT TO SELL AND PURCHASE THE SHARES

        2.1    PURCHASE AND SALE

        Subject to the terms and conditions of this Agreement, the Purchaser
agrees to purchase, and the Company agrees to sell and issue to the Purchaser,
at the Closing (as defined below), that number of Shares set forth opposite the
Purchaser's name on Schedule A attached hereto.

        2.2    PURCHASE PRICE

        The purchase price of each Share (the "Per Share Price") shall be
$11.00.

3.      DELIVERY OF THE SHARES AT THE CLOSING

               (a) The completion of the purchase and sale of the Shares (the
"Closing"), shall occur at the offices of Perkins Coie LLP, 1201 Third Avenue,
48th Floor, Seattle, Washington 98101, counsel to the Company, at 5:00 p.m. EST
on April __, 2000 or such other time and date as may be agreed by the parties.

               (b) At the Closing, the Company shall authorize its transfer
agent (the "Transfer Agent") to issue to the Purchaser one or more stock
certificates registered in the name of the Purchaser, or in such nominee name(s)
as designated by the Purchaser in writing, representing the number of Shares set
forth in Section 2 above and bearing an appropriate legend referring to the fact
that the Shares were sold in reliance upon the exemption from registration
provided by Section 4(2) of the Securities Act of 1933, as amended (the
"Securities Act"), and Rule 506 under the Securities Act. The Company will
deliver certificates representing the number of Shares set forth in Section 2
against delivery of payment for the Shares by the Purchaser via wire transfer to
Bank of America account number 1113703, routing number 125000024.

               (c) The Company's obligation to complete the purchase and sale of
the Shares shall be subject to the following conditions, any one or more of
which may be waived by the Company:

                                       1
<PAGE>   2

              (i)     receipt by the Company of same-day funds in the full
                      amount of the purchase price for the Shares being
                      purchased under this Agreement; and

              (ii)    the accuracy in all material respects of the
                      representations and warranties made by the Purchaser and
                      the fulfillment in all material respects of those
                      undertakings of the Purchaser to be fulfilled on or before
                      the Closing.

               (d) The Purchaser's obligation to accept delivery of such stock
certificates and to pay for the Shares evidenced by the certificates shall be
subject to the following conditions, any one or more of which may be waived by
the Purchaser:

              (i)     the representations and warranties made by the Company in
                      this Agreement shall be accurate in all material respects
                      and the undertakings of the Company shall have been
                      fulfilled in all material respects on or before the
                      Closing;

              (ii)    the Company shall have delivered to the Purchaser a
                      certificate executed by the president and chief operating
                      officer or other executive officer of the Company, dated
                      the Closing date, in form and substance reasonably
                      satisfactory to the Purchaser, to the effect that the
                      representations and warranties of the Company set forth in
                      Section 4 hereof are true and correct in all material
                      respects as of the date of this Agreement and as of the
                      Closing Date, and that the Company has complied with all
                      the agreements and satisfied all the conditions in this
                      Agreement on its part to be performed or satisfied on or
                      before the Closing date; and

             (iii)    the Company shall have obtained aggregate gross proceeds
                      of at least $11 million from the Offering on the Closing
                      date.

4.      REPRESENTATIONS AND WARRANTIES OF THE COMPANY

        The Company hereby represents and warrants to the Purchaser as follows:

        4.1    ORGANIZATION AND QUALIFICATION

        The Company has been duly incorporated and is validly existing as a
corporation in good standing under the laws of the state of Washington. The
Company has the corporate power and authority to own, lease and operate its
properties and to conduct its business as currently conducted and to enter into
and perform its obligations under this Agreement. The Company is duly qualified
as a foreign corporation to transact business and is in good standing in each
jurisdiction in which such qualification is required, whether by reason of the
ownership or leasing of property or the conduct of business, except where the
failure to so qualify would not, singly or in the aggregate, have a material
adverse effect on the condition, financial or otherwise, or the earnings,
assets, business affairs or business prospects of the Company.

                                       2
<PAGE>   3

        4.2    CAPITALIZATION

               (a) The authorized capital stock of the Company consists of
60,000,000 shares of Common Stock and 3,000,000 shares of Preferred Stock.

               (b) As of March 31, 2000, the issued and outstanding capital
stock of the Company consists of 21,811,808 shares of Common Stock and the
shares of Series 1 convertible exchangeable preferred stock described in
subsection (f) below. The shares of issued and outstanding capital stock of the
Company have been duly authorized and validly issued, are fully paid and
nonassessable and have not been issued in violation of or are not otherwise
subject to any preemptive or other similar rights.

               (c) The Company has reserved an aggregate of 4,250,000 shares of
Common Stock for issuance upon the exercise of stock options granted or
available for future grant under the Company's 1994 Stock Option Plan and its
1991 Stock Option Plan for Non-Employee Directors, of which options to purchase
an aggregate of 2,890,453 shares of Common Stock have been granted and are
outstanding and an aggregate of 572,184 shares were available for grant at March
31, 2000. The Company has proposed, subject to shareholder approval, to increase
the number of shares issuable under the 1994 Stock Option Plan by 500,000
shares.

               (d) The Company has reserved 305,000 shares of Common Stock for
issuance upon the exercise of outstanding warrants to purchase Common Stock.

               (e) The Company has reserved 250,000 shares of Common Stock for
issuance under its 1991 Restricted Stock Program, of which 194,000 remained
available for grant at March 31, 2000.

               (f) 208,240 shares of Series 1 Convertible Preferred Stock of the
Company were convertible into 236,636 shares of the Common Stock as of March 31,
2000.

               (g) The Company has $1,185,000 in principal of convertible
subordinated debentures outstanding, which will be retired in June 2000. The
debentures are convertible at the option of the holder into shares of Common
Stock at a conversion price of $25.80 per share, subject to adjustment under
certain conditions.

        With the exception of the foregoing, there are no outstanding
subscriptions, options, warrants, convertible or exchangeable securities or
other rights granted to or by the Company to purchase shares of Common Stock or
other securities of the Company, and there are no commitments, plans or
arrangements to issue any shares of Common Stock or any security convertible
into or exchangeable for Common Stock.

        4.3    ISSUANCE, SALE AND DELIVERY OF THE SHARES

               (a) The Shares have been duly authorized for issuance and sale to
the Purchaser pursuant to this Agreement and, when issued and delivered by the
Company pursuant to this Agreement against payment of the consideration set
forth in this Agreement, will be validly issued and fully paid and nonassessable
and free and clear of all pledges, liens and

                                       3
<PAGE>   4

encumbrances. The certificates evidencing the Shares are in due and proper form
under Washington law.

               (b) The issuance of the Shares is not subject to preemptive or
other similar rights. No further approval or authority of the shareholders or
the Board of Directors of the Company will be required for the issuance and sale
of the Shares to be sold by the Company as contemplated in this Agreement.
Except for shareholders who purchase Shares in the Offering, no shareholder of
the Company has any right (other than any right that has been waived following
notification of the Company's intent to file the Registration Statement (as
hereinafter defined) or has expired by reason of lapse of time) to require the
Company to register the sale of any securities owned by such holder in such
Registration Statement.

               (c) Subject to the accuracy of the Purchaser's representations
and warranties in Section 5 of this Agreement, the offer, sale, and issuance of
the Shares in conformity with the terms of this Agreement constitute
transactions exempt from the registration requirements of Section 5 of the
Securities Act and from the registration or qualification requirements of the
laws of any applicable state or United States jurisdiction.

        4.4    FINANCIAL STATEMENTS

        The financial statements included in the Company Documents (as
hereinafter defined) present fairly the financial position of the Company as of
the dates indicated and the results of their operations for the periods
specified. Except as otherwise stated in such Company Documents, such financial
statements have been prepared in conformity with generally accepted accounting
principles applied on a consistent basis, and any supporting schedules included
with the financial statements present fairly the information stated in the
financial statements. The financial and statistical data set forth in the
Company Documents were prepared on an accounting basis consistent with such
financial statements.

        4.5    NO MATERIAL CHANGE

        Since December 31, 1999,

               (a) there has been no material adverse change or any development
involving a prospective material adverse change in or affecting the condition,
financial or otherwise, or in the earnings, assets, business affairs or business
prospects of the Company, whether or not arising in the ordinary course of
business;

               (b) there have been no transactions entered into by the Company
other than those in the ordinary course of business, which are material with
respect to the Company; and

               (c) there has been no dividend or distribution of any kind
declared, paid or made by the Company on any class of its capital stock, except
for the approval by the Board of Directors of the payment of the Series 1
Preferred Stock dividend of $1.21875 per share, payable on June 1, 2000 for
shareholders of record on May 19, 2000.

        The Company has no material contingent obligations.

                                       4
<PAGE>   5

        4.6    ENVIRONMENTAL

        Except as would not, singly or in the aggregate, reasonably be expected
to have a material adverse effect on the condition, financial or otherwise, or
the earnings, assets, business affairs or business prospects of the Company,

               (a) the Company is in compliance with all applicable
Environmental Laws (as defined below);

               (b) the Company has all permits, authorizations and approvals
required under any applicable Environmental Laws and is in compliance with the
requirements of such permits authorizations and approvals; and

               (c) there are no pending or, to the best knowledge of the
Company, threatened Environmental Claims against the Company.

        For purposes of this Agreement, the following terms shall have the
following meanings: "Environmental Law" means any United States (or other
applicable jurisdiction's) Federal, state, local or municipal statute, law,
rule, regulation, ordinance, code, policy or rule of common law and any judicial
or administrative interpretation thereof, including any judicial or
administrative order, consent decree or judgment, relating to the environment,
health, safety or any chemical, material or substance, exposure to which is
prohibited, limited or regulated by any governmental authority. "Environmental
Claims" means any administrative, regulatory or judicial actions, suits,
demands, demand letters, claims, liens, notices of noncompliance or violation,
investigations or proceedings relating to any Environmental Law.

        4.7    NO DEFAULTS

        The Company is not in violation of its articles of incorporation or
bylaws or in material default in the performance or observance of any
obligation, agreement, covenant or condition contained in any material contract,
indenture, mortgage, loan agreement, deed, trust, note, lease, sublease, voting
agreement, voting trust, or other instrument or agreement to which the Company
is a party or by which it may be bound, or to which any of the property or
assets of the Company is subject.

        4.8    LABOR MATTERS

        No labor dispute with the employees of the Company exists or, to the
best knowledge of the Company, is imminent.

        4.9    NO ACTIONS

        There is no action, suit or proceeding before or by any court or
governmental agency or body, domestic or foreign, now pending, or, to the
knowledge of the Company, threatened, against or affecting the Company which,
singly or in the aggregate, would result in any material adverse change in the
condition, financial or otherwise, or in the earnings, business affairs or
business prospects of the Company, or which, singly or in the aggregate, would
materially and

                                       5
<PAGE>   6

adversely affect the properties or assets thereof or which would materially and
adversely affect the consummation of this Agreement, nor, to the best knowledge
of the Company, is there any reasonable basis therefor. The Company is not in
default with respect to any judgment, order or decree of any court or
governmental agency or instrumentality which, singly or in the aggregate, would
have a material adverse effect on the assets, properties or business of the
Company.

        4.10   INTELLECTUAL PROPERTY

               (a) The Company, to the best of its knowledge, owns or is
licensed to use all patents, patent applications, inventions, trademarks, trade
names, applications for registration of trademarks, service marks, service mark
applications, copyrights, know-how, manufacturing processes, formulae, trade
secrets, licenses and rights in any thereof and any other intangible property
and assets (in this Agreement called the "Proprietary Rights") that are material
to the business of the Company as now conducted and as proposed to be conducted.

               (b) The Company does not have any knowledge of, and the Company
has not given or received any notice of, any pending conflicts with or
infringement of the rights of others with respect to any Proprietary Rights or
with respect to any license of Proprietary Rights which are material to the
business of the Company.

               (c) No action, suit, arbitration, or legal, administrative or
other proceeding, or investigation is pending, or, to the best knowledge of the
Company, threatened, which involves any Proprietary Rights, nor, to the best
knowledge of the Company, is there any reasonable basis therefor.

               (d) The Company is not subject to any judgment, order, writ,
injunction or decree of any court or any Federal, state, local, foreign or other
governmental department, commission, board, bureau, agency or instrumentality,
domestic or foreign, or any arbitrator, and has not entered into or is not a
party to any contract which restricts or impairs the use of any such Proprietary
Rights in a manner which would have a material adverse effect on the use of any
of the Proprietary Rights.

               (e) No Proprietary Rights used by the Company, and no services or
products sold by the Company, conflict with or infringe upon any proprietary
rights of any third party. The Company has not received written notice of any
pending conflict with or infringement upon such third-party proprietary rights.

               (f) The Company has not entered into any consent,
indemnification, forbearance to sue or settlement agreement with respect to
Proprietary Rights other than in the ordinary course of business. No claims have
been asserted by any person with respect to the validity of the Company's
ownership or right to use the Proprietary Rights and, to the best knowledge of
the Company, there is no reasonable basis for any such claim to be successful.

               (g) The Proprietary Rights that are material to the business of
the Company are valid and enforceable and no registration relating thereto has
lapsed, expired or been abandoned or cancelled or is the subject of cancellation
or other adversarial proceedings, and all applications therefor are pending and
are in good standing.

                                       6
<PAGE>   7

               (h) To the best of its knowledge, the Company has complied, in
all material respects, with its obligations relating to the protection of the
Proprietary Rights which are material to the business of the Company used
pursuant to licenses.

               (i) To the best knowledge of the Company, no person is infringing
on or violating the Proprietary Rights.

        4.11   PERMITS

        The Company possesses and is operating in compliance with all material
licenses, certificates, consents, authorities, approvals and permits from all
state, Federal, foreign and other regulatory agencies or bodies necessary to
conduct the businesses now operated by it, and the Company has not received any
notice of proceedings relating to the revocation or modification of any such
permit or any circumstance which would lead it to believe that such proceedings
are reasonably likely which, singly or in the aggregate, if the subject of an
unfavorable decision, ruling or finding, would materially and adversely affect
the condition, financial or otherwise, or the earnings, assets, business affairs
or business prospects of the Company.

        4.12   DUE EXECUTION, DELIVERY AND PERFORMANCE

               (a) This Agreement has been duly executed and delivered by the
Company and constitutes a valid and binding obligation of the Company,
enforceable against the Company in accordance with its terms, except as rights
to indemnity and contribution under this Agreement may be limited by Federal or
state securities laws or the public policy underlying such laws.

               (b) The execution, delivery and performance of this Agreement and
the consummation of the transactions contemplated in this Agreement and the
fulfillment of the terms of this Agreement have been duly authorized by all
necessary corporate action and will not conflict with or constitute a breach of,
or default under, or result in the creation or imposition of any lien, charge or
encumbrance upon any property or assets of the Company pursuant to, any
contract, indenture, mortgage, loan agreement, deed, trust, note, lease,
sublease, voting agreement, voting trust or other instrument or agreement to
which the Company is a party or by which it may be bound, or to which any of the
property or assets of the Company is subject, nor will such action result in any
violation of the provisions of the articles of incorporation or bylaws of the
Company or any applicable statute, law, rule, regulation, ordinance, decision,
directive or order.

        4.13   PROPERTIES

        The Company has good and marketable title to its properties, free and
clear of all material security interests, mortgages, pledges, liens, charges,
encumbrances and claims of record. The properties of the Company are, in the
aggregate, in good repair (reasonable wear and tear excepted), and suitable for
their respective uses. Any real property held under lease by the Company is held
under valid, subsisting and enforceable leases with such exceptions as are not
material and do not interfere with the conduct of the business of the Company.
The Company owns or leases all such properties as are necessary to its business
or operations as now conducted.

                                       7
<PAGE>   8

        4.14   COMPLIANCE

        The Company has conducted and is conducting its business in compliance
with all applicable Federal, state, local and foreign statutes, laws, rules,
regulations, ordinances, codes, decisions, decrees, directives and orders,
except where the failure to do so would not, singly or in the aggregate, have a
material adverse effect on the condition, financial or otherwise, or on the
earnings, assets, business affairs or business prospects of the Company.

        4.15   SECURITY MEASURES

        The Company takes security measures designed to enable the Company to
assert trade secret protection in its non-patented technology.

        4.16   CONTRIBUTIONS

        To the best of the Company's knowledge, neither the Company nor any
employee or agent of the Company has made any payment of funds of the Company or
received or retained any funds in violation of any law, rule or regulation.

        4.17   USE OF PROCEEDS; INVESTMENT COMPANY

        The Company intends to use the net proceeds from the sale of the Shares
for research and development, pre-launch activities, general corporate purposes
and working capital. The Company is not now, and after the sale of the Shares
under this Agreement and under all other agreements and the application of the
net proceeds from the sale of the Shares described in the preceding sentence
will not be, an "investment company" within the meaning of the Investment
Company Act of 1940, as amended.

        4.18   PRIOR OFFERINGS

        All offers and sales of capital stock of the Company before the date of
this Agreement were at all relevant times duly registered or exempt from the
registration requirements of the Securities Act and were duly registered or
subject to an available exemption from the registration requirements of the
applicable state securities or Blue Sky laws.

        4.19   TAXES

        The Company has filed all material tax returns required to be filed,
which returns are true and correct in all material respects, and the Company is
not in default in the payment of any taxes, including penalties and interest,
assessments, fees and other charges, shown thereon due or otherwise assessed,
other than those being contested in good faith and for which adequate reserves
have been provided or those currently payable without interest which were
payable pursuant to said returns or any assessments with respect thereto.

                                       8
<PAGE>   9

        4.20   OTHER GOVERNMENTAL PROCEEDINGS

        To the Company's knowledge, there are no rulemaking or similar
proceedings before The United States Food and Drug Administration or comparable
Federal, state, local or foreign government bodies that involve or affect the
Company, which, if the subject of an action unfavorable to the Company, would
reasonably be expected to materially and adversely affect the condition,
financial or otherwise, or the earnings, assets, business affairs or business
prospects of the Company.

        4.21   NON-COMPETITION AGREEMENTS

        To the knowledge of the Company, any full-time employee who has entered
into any non-competition, non-disclosure, confidentiality or other similar
agreement with any party other than the Company is neither in violation of nor
is expected to be in violation of that agreement as a result of the business
currently conducted or expected to be conducted by the Company or such person's
performance of his or her obligations to the Company. The Company has not
received written notice that any consultant or scientific advisor of the Company
is in violation of any non-competition, non-disclosure, confidentiality or
similar agreement.

        4.22   TRANSFER TAXES

        On the Closing date, all stock transfer or other taxes (other than
income taxes) that are required to be paid in connection with the sale and
transfer of the Shares to be sold to the Purchaser under this Agreement will be,
or will have been, fully paid or provided for by the Company and all laws
imposing such taxes will be or will have been fully complied with.

        4.23   INSURANCE

        The Company maintains insurance of the type and in the amount that the
Company reasonably believes is adequate for its business, including, but not
limited to, insurance covering all real and personal property owned or leased by
the Company against theft, damage, destruction, acts of vandalism and all other
risks customarily insured against by similarly situated companies, all of which
insurance is in full force and effect.

        4.24   GOVERNMENTAL CONSENTS

        No registration, authorization, approval, qualification or consent of
any court or governmental authority or agency is necessary in connection with
the execution and delivery of this Agreement or the offering, issuance or sale
of the Shares under this Agreement, except such as may be required under the
Securities Act or the rules and regulations promulgated thereunder or state
securities or Blue Sky laws, or such as may be required by the National
Association of Securities Dealers, Inc.

                                       9
<PAGE>   10

        4.25   SECURITIES AND EXCHANGE COMMISSION FILINGS

        The Company has timely filed with the Securities and Exchange Commission
(the "Commission") all documents required to be filed by the Company under the
Exchange Act of 1934, as amended (the "Exchange Act.")

        4.26   ADDITIONAL INFORMATION

        The Company represents and warrants that the information contained in
the following documents (the "Company Documents"), which will be provided to
Purchaser before the Closing, is or will be true and correct in all material
respects as of their respective final dates:

               (a) the Company's Annual Report on Form 10-K for the fiscal year
ended December 31, 1999;

               (b) the Company's Quarterly Reports on Form 10-Q for the fiscal
quarters ended March 31, 1999, June 30, 1999 and September 30, 1999;

               (c) the Company's Proxy Statement for its 1999 Annual Meeting of
Shareholders; and

               (d) all other documents, if any, filed by the Company with the
Commission since January 1, 1999 pursuant to the reporting requirements of the
Exchange Act.

        4.27   CONTRACTS

        The contracts described in the Company Documents or incorporated by
reference therein are in full force and effect on the date hereof, except for
contracts the termination or expiration of which would not, singly or in the
aggregate, have a material adverse effect on the business, properties or assets
of the Company. Neither the Company nor, to the best knowledge of the Company,
any other party is in breach of or default under any such contracts.

5.      REPRESENTATIONS, WARRANTIES AND COVENANTS OF THE PURCHASER

        5.1    SECURITIES LAW REPRESENTATIONS AND WARRANTIES

        The Purchaser represents, warrants and covenants to the Company as
follows:

               (a) The Purchaser is knowledgeable, sophisticated and experienced
in making, and is qualified to make, decisions with respect to investments in
shares representing an investment decision like that involved in the purchase of
the Shares, including investments in securities issued by the Company, and has
requested, received, reviewed and considered all information it deems relevant
in making an informed decision to purchase the Shares.

               (b) The Purchaser is acquiring the number of Shares set forth in
Section 2 above in the ordinary course of its business and for its own account
for investment (as defined for purposes of the Hart-Scott-Rodino Antitrust
Improvement Act of 1976 and the regulations thereunder) only, and has no present
intention of distributing any of the Shares nor any

                                       10
<PAGE>   11

arrangement or understanding with any other persons regarding the distribution
of such Shares within the meaning of Section 2(11) of the Securities Act, other
than as contemplated in Section 7 of this Agreement.

               (c) The Purchaser will not, directly or indirectly, offer, sell,
pledge, transfer or otherwise dispose of (or solicit any offers to buy, purchase
or otherwise acquire or take a pledge of) any of the Shares except in compliance
with the Securities Act and the Rules and Regulations.

               (d) The Purchaser has completed or caused to be completed the
Stock Certificate Questionnaire and the Registration Statement Questionnaire,
attached to this Agreement as Appendices I and II, for use in preparation of the
Registration Statement (as defined in Section 7.3 below), and the answers to the
Questionnaires are true and correct as of the date of this Agreement and will be
true and correct as of the effective date of the Registration Statement;
provided that the Purchaser shall be entitled to update such information by
providing notice thereof to the Company before the effective date of such
Registration Statement.

               (e) The Purchaser has, in connection with its decision to
purchase the number of Shares set forth in Section 2 above, relied solely upon
the Company Documents and the representations and warranties of the Company
contained in this Agreement.

               (f) The Purchaser is an "accredited investor" within the meaning
of Rule 501 of Regulation D promulgated under the Securities Act.

        5.2    RESALES OF SHARES

               (a) The Purchaser hereby covenants with the Company not to make
any sale of the Shares without satisfying the requirements of the Securities Act
and the Rules and Regulations, including, in the event of any resale under the
Registration Statement, the prospectus delivery requirements under the
Securities Act, and the Purchaser acknowledges and agrees that such Shares are
not transferable on the books of the Company pursuant to a resale under the
Registration Statement unless the certificate submitted to the transfer agent
evidencing the Shares is accompanied by a separate officer's certificate:

              (i)     in the form of Appendix III to this Agreement;

              (ii)    executed by an officer of, or other authorized person
                      designated by, the Purchaser, and

             (iii)    to the effect that (A) the Shares have been sold in
                      accordance with the Registration Statement and (B) the
                      requirement of delivering a current prospectus has been
                      satisfied.

               (b) The Purchaser acknowledges that there may occasionally be
times when the Company determines the use of the prospectus forming a part of
the Registration Statement (the "Prospectus," as further defined in Section
7.3.1 below) should be suspended until such time as an amendment or supplement
to the Registration Statement or the Prospectus has been filed by

                                       11
<PAGE>   12

the Company and any such amendment to the Registration Statement is declared
effective by the Commission, or until such time as the Company has filed an
appropriate report with the Commission pursuant to the Exchange Act. The
Purchaser hereby covenants that it will not sell any Shares pursuant to the
Prospectus during the period commencing at the time at which the Company gives
the Purchaser written notice of the suspension of the use of the Prospectus and
ending at the time the Company gives the Purchaser written notice that the
Purchaser may thereafter effect sales pursuant to the Prospectus. The Company
may, upon written notice to the Purchaser, suspend the use of the Prospectus for
two 30-day periods in any 365-day period based on the reasonable determination
of the Company's Board of Directors that there is a significant business purpose
for such determination, such as pending corporate developments, public filings
with the SEC or similar events. The Company shall in no event be required to
disclose the business purpose for which it has suspended the use of the
Prospectus if the Company determines in its good faith judgment that the
business purpose should remain confidential.

               (c) The Purchaser further covenants to notify the Company
promptly of the sale of any of its Shares.

        5.3    DUE EXECUTION, DELIVERY AND PERFORMANCE

               (a) This Agreement has been duly executed and delivered by the
Purchaser and constitutes a valid and binding obligation of the Purchaser,
enforceable against the Purchaser in accordance with its terms, except as rights
to indemnity and contribution under this Agreement may be limited by Federal or
state securities laws or the public policy underlying such laws.

               (b) The execution, delivery and performance of this Agreement and
the consummation of the transactions contemplated in this Agreement and the
fulfillment of the terms of this Agreement have been duly authorized by all
necessary corporate action and will not conflict with or constitute a breach of,
or default under, or result in the creation or imposition of any lien, charge or
encumbrance upon any property or assets of the Purchaser pursuant to, any
contract, indenture, mortgage, loan agreement, deed, trust, note, lease,
sublease, voting agreement, voting trust or other instrument or agreement to
which the Purchaser is a party or by which it or any of them may be bound, or to
which any of the property or assets of the Purchaser is subject, nor will such
action result in any violation of the provisions of the charter or bylaws of the
Purchaser or any applicable statute, law, rule, regulation, ordinance, decision,
directive or order.

6.      SURVIVAL OF REPRESENTATIONS, WARRANTIES AND AGREEMENTS.

        Notwithstanding any investigation made by any party to this Agreement,
all covenants, agreements, representations and warranties made by the Company
and the Purchaser in this Agreement and in the certificates for the Shares
delivered pursuant to this Agreement shall survive the execution of this
Agreement, the delivery to the Purchaser of the Shares being purchased and the
payment therefor.

                                       12
<PAGE>   13

7.      REGISTRATION; COMPLIANCE WITH THE SECURITIES ACT

        7.1    REGISTRATION OF SHARES

               7.1.1  REGISTRATION STATEMENT; EXPENSES

        The Company shall use its best efforts to:

               (a) Within five (5) business days after the Closing, prepare and
file with the Commission a Registration Statement on Form S-3 relating to the
sale of the Shares by the Purchaser from time to time on the Nasdaq National
Market (or the facilities of any national securities exchange on which the
Company's Common Stock is then traded) or in privately negotiated transactions
(the "Registration Statement");

               (b) subject to receipt of necessary information from the
Purchaser, to cause the Commission to notify the Company of the Commission's
willingness to declare the Registration Statement effective within 90 days after
the Closing;

               (c) prepare and file with the Commission such amendments and
supplements to the Registration Statement and the Prospectus (as defined in
Section 7.3.1 below) and take such other action, if any, as may be necessary to
keep the Registration Statement effective until the earlier of (i) two years
after the effective date of the Registration Statement, (ii) the date on which
the Shares may be resold by the Purchaser without registration or without regard
to any volume limitations by reason of Rule 144(k) under the Securities Act or
any other rule of similar effect or (iii) all of the Shares have been sold
pursuant to the Registration Statement or Rule 144(k) under the Securities Act
or any other rule of similar effect;

               (d) furnish to the Purchaser with respect to the Shares
registered under the Registration Statement such reasonable number of copies of
the Prospectus, including any supplements to or amendments of the Prospectus, in
order to facilitate the public sale or other disposition of all or any of the
Shares by the Purchaser; provided, however, that the obligation of the Company
to deliver copies of the Prospectus to the Purchaser shall be subject to the
receipt by the Company of reasonable assurances from the Purchaser that the
Purchaser will comply with the applicable provisions of the Securities Act and
of such other securities or blue sky laws as may be applicable in connection
with any use of the Prospectus;

               (e) during the period when copies of the Prospectus are required
to be delivered under the Securities Act or the Exchange Act, will file all
documents required to be filed with the Commission pursuant to Section 13, 14 or
15 of the Exchange Act within the time periods required by the Exchange Act and
the rules and regulations promulgated thereunder;

               (f) file documents required of the Company for customary Blue Sky
clearance in states specified in writing by the Purchaser; provided, however,
that the Company shall not be required to qualify to do business or consent to
service of process in any jurisdiction in which it is not now so qualified or
has not so consented; and

                                       13
<PAGE>   14

               (g) bear all expenses in connection with the procedures in
paragraphs (a) through (f) of this Section 7.1.1 and the registration of the
Shares pursuant to the Registration Statement, other than any fees and expenses
of counsel or other advisers to the Purchaser, brokerage fees and commissions
incurred by the Purchaser.

        The Purchaser acknowledges and agrees that the Registration Statement
filed under this Section, in addition to the Shares held by the Purchaser, shall
include Shares held by other purchasers in the Offering and, at the Company's
election, may include shares of Common Stock held by other Company shareholders
or issuable under any warrants, options or convertible securities.

               7.1.2  DELAY IN EFFECTIVENESS OF REGISTRATION STATEMENT

        In the event that the Registration Statement is not declared effective
within 90 days after the Closing, the Company shall pay to the Purchaser
liquidated damages in an amount equal to 0.25% of the number of Shares purchased
by the Purchaser pursuant to this Agreement for each week thereafter that the
Registration Statement is not declared effective. Such liquidated damages shall
be paid through the issuance of additional Shares at such time as the
Registration Statement is declared effective. No liquidated damages shall be
paid under this Agreement if effectiveness of the Registration Statement is
prevented or delayed due to fire, explosion, flood, riot, labor dispute,
accident, act of God, change in existing regulation or law, or other similar
event beyond the Company's reasonable control.

        7.2    TRANSFER OF SHARES AFTER REGISTRATION

        The Purchaser agrees that it will not effect any disposition of the
Shares or its right to purchase the Shares that would constitute a sale within
the meaning of the Securities Act, except as contemplated in the Registration
Statement referred to in Section 7.1 or as otherwise permitted by law, and that
it will promptly notify the Company of any changes in the information set forth
in the Registration Statement regarding the Purchaser or its plan of
distribution.

        7.3    INDEMNIFICATION

        For the purpose of this Section 7.3, the term "Registration Statement"
shall include any preliminary or final prospectus, exhibit, supplement or
amendment included in or relating to the Registration Statement referred to in
Section 7.1.

               7.3.1  INDEMNIFICATION BY THE COMPANY

        The Company agrees to indemnify and hold harmless the Purchaser and each
person, if any, who controls the Purchaser within the meaning of the Securities
Act, against any losses, claims, damages, liabilities or expenses, joint or
several, to which the Purchaser or such controlling person may become subject,
under the Securities Act, the Exchange Act, or any other federal or state
statutory law or regulation, or at common law or otherwise (including in
settlement of any litigation, if such settlement is effected with the written
consent of the Company, which consent shall not be unreasonably withheld),
insofar as such losses, claims, damages, liabilities or expenses (or actions in
respect thereof as contemplated below) arise out of

                                       14
<PAGE>   15

or are based upon any untrue statement or alleged untrue statement of any
material fact contained in the Registration Statement, including the Prospectus,
financial statements and schedules, and all other documents filed as a part
thereof, as amended at the time of effectiveness of the Registration Statement,
including any information deemed to be a part thereof as of the time of
effectiveness pursuant to paragraph (b) of Rule 430A, or pursuant to Rule 434,
of the Rules and Regulations, or the Prospectus, in the form first filed with
the Commission pursuant to Rule 424(b) of the Regulations, or filed as part of
the Registration Statement at the time of effectiveness if no Rule 424(b) filing
is required (the "Prospectus"), or any amendment or supplement thereto, or arise
out of or are based upon the omission or alleged omission to state in any of
them a material fact required to be stated therein or necessary to make the
statements in any of them, in light of the circumstances under which they were
made, not misleading, or arise out of or are based in whole or in part on any
inaccuracy in the representations and warranties of the Company contained in
this Agreement, or any failure of the Company to perform its obligations under
this Agreement or under law, and will reimburse the Purchaser and each such
controlling person for any legal and other expenses as such expenses are
reasonably incurred by the Purchaser or such controlling person in connection
with investigating, defending, settling, compromising or paying any such loss,
claim, damage, liability, expense or action; provided, however, that the Company
will not be liable in any such case to the extent that any such loss, claim,
damage, liability or expense arises out of or is based upon (i) an untrue
statement or alleged untrue statement or omission or alleged omission made in
the Registration Statement, the Prospectus or any amendment or supplement of the
Registration Statement or Prospectus in reliance upon and in conformity with
written information furnished to the Company by or on behalf of the Purchaser
expressly for use in the Registration Statement or the Prospectus, or (ii) the
failure of the Purchaser to comply with the covenants and agreements contained
in Sections 5.2 or 7.2 of this Agreement respecting resale of the Shares, or
(iii) the inaccuracy of any representations made by the Purchaser in this
Agreement or (iv) any untrue statement or omission of a material fact required
to make such statement not misleading in any Prospectus that is corrected in any
subsequent Prospectus that was delivered to the Purchaser before the pertinent
sale or sales by the Purchaser.

               7.3.2  INDEMNIFICATION BY THE PURCHASER

        The Purchaser will indemnify and hold harmless the Company, each of its
directors, each of its officers who signed the Registration Statement and each
person, if any, who controls the Company within the meaning of the Securities
Act, against any losses, claims, damages, liabilities or expenses to which the
Company, each of its directors, each of its officers who signed the Registration
Statement or controlling person may become subject, under the Securities Act,
the Exchange Act, or any other federal or state statutory law or regulation, or
at common law or otherwise (including in settlement of any litigation, if such
settlement is effected with the written consent of the Purchaser, which consent
shall not be unreasonably withheld) insofar as such losses, claims, damages,
liabilities or expenses (or actions in respect thereof as contemplated below)
arise out of or are based upon (i) any failure to comply with the covenants and
agreements contained in Sections 5.2 or 7.2 of this Agreement respecting the
sale of the Shares or (ii) the inaccuracy of any representation made by the
Purchaser in this Agreement or (iii) any untrue or alleged untrue statement of
any material fact contained in the Registration Statement, the Prospectus, or
any amendment or supplement to the Registration Statement or

                                       15
<PAGE>   16

Prospectus, or arise out of or are based upon the omission or alleged omission
to state therein a material fact required to be stated therein or necessary to
make the statements therein not misleading, in each case to the extent, but only
to the extent, that such untrue statement or alleged untrue statement or
omission or alleged omission was made in the Registration Statement, the
Prospectus, or any amendment or supplement thereto, in reliance upon and in
conformity with written information furnished to the Company by or on behalf of
the Purchaser expressly for use therein, and the Purchaser will reimburse the
Company, each of its directors, each of its officers who signed the Registration
Statement or controlling person for any legal and other expense reasonably
incurred by the Company, each of its directors, each of its officers who signed
the Registration Statement or controlling person in connection with
investigating, defending, settling, compromising or paying any such loss, claim,
damage, liability, expense or action.

               7.3.3  INDEMNIFICATION PROCEDURE

               (a) Promptly after receipt by an indemnified party under this
Section 7.3 of notice of the threat or commencement of any action, such
indemnified party will, if a claim in respect thereof is to be made against an
indemnifying party under this Section 7.3, promptly notify the indemnifying
party in writing of the claim; but the omission so to notify the indemnifying
party will not relieve it from any liability which it may have to any
indemnified party for contribution or otherwise than under the indemnity
agreement contained in this Section 7.3 or to the extent it is not prejudiced as
a result of such failure.

               (b) In case any such action is brought against any indemnified
party and such indemnified party seeks or intends to seek indemnity from an
indemnifying party, the indemnifying party will be entitled to participate in,
and, to the extent that it may wish, jointly with all other indemnifying parties
similarly notified, to assume the defense thereof with counsel reasonably
satisfactory to such indemnified party; provided, however, if the defendants in
any such action include both the indemnified party and the indemnifying party
and the indemnified party shall have reasonably concluded that there may be a
conflict between the positions of the indemnifying party and the indemnified
party in conducting the defense of any such action or that there may be legal
defenses available to it or other indemnified parties that are different from or
additional to those available to the indemnifying party, the indemnified party
or parties shall have the right to select separate counsel to assume such legal
defenses and to otherwise participate in the defense of such action on behalf of
such indemnified party or parties. Upon receipt of notice from the indemnifying
party to such indemnified party of its election so to assume the defense of such
action and approval by the indemnified party of counsel, the indemnifying party
will not be liable to such indemnified party under this Section 7.3 for any
legal or other expenses subsequently incurred by such indemnified party in
connection with the defense thereof unless:

              (i)     the indemnified party shall have employed such counsel in
                      connection with the assumption of legal defenses in
                      accordance with the proviso to the preceding sentence (it
                      being understood, however, that the indemnifying party
                      shall not be liable for the expenses of more than one
                      separate counsel, approved by such indemnifying party in
                      the case of

                                       16
<PAGE>   17

                      paragraph (a), representing all of the indemnified parties
                      who are parties to such action) or

              (ii)    the indemnifying party shall not have employed counsel
                      reasonably satisfactory to the indemnified party to
                      represent the indemnified party within a reasonable time
                      after notice of commencement of action, in each of which
                      cases the reasonable fees and expenses of counsel shall be
                      at the expense of the indemnifying party.

               7.3.4  CONTRIBUTION

        If the indemnification provided for in this Section 7.3 is required by
its terms but is for any reason held to be unavailable to or otherwise
insufficient to hold harmless an indemnified party under this Section 7.3 in
respect to any losses, claims, damages, liabilities or expenses referred to in
this Agreement, then each applicable indemnifying party shall contribute to the
amount paid or payable by such indemnified party as a result of any losses,
claims, damages, liabilities or expenses referred to in this Agreement

               (a) in such proportion as is appropriate to reflect the relative
benefits received by the Company and the Purchaser from the placement of Common
Stock or

               (b) if the allocation provided by clause (a) above is not
permitted by applicable law, in such proportion as is appropriate to reflect not
only the relative benefits referred to in clause (a) above but the relative
fault of the Company and the Purchaser in connection with the statements or
omissions or inaccuracies in the representations and warranties in this
Agreement that resulted in such losses, claims, damages, liabilities or
expenses, as well as any other relevant equitable considerations.

        The respective relative benefits received by the Company on the one hand
and the Purchaser on the other shall be deemed to be in the same proportion as
the amount paid by the Purchaser to the Company pursuant to this Agreement for
the Shares purchased by the Purchaser that were sold pursuant to the
Registration Statement bears to the difference (the "Difference") between the
amount the Purchaser paid for the Shares that were sold pursuant to the
Registration Statement and the amount received by the Purchaser from such sale.
The relative fault of the Company and the Purchaser shall be determined by
reference to, among other things, whether the untrue or alleged statement of a
material fact or the omission or alleged omission to state a material fact or
the inaccurate or the alleged inaccurate representation or warranty relates to
information supplied by the Company or by the Purchaser and the parties'
relative intent, knowledge, access to information and opportunity to correct or
prevent such statement or omission. The amount paid or payable by a party as a
result of the losses, claims, damages, liabilities and expenses referred to
above shall be deemed to include, subject to the limitations set forth in
Section 7.3.3, any legal or other fees or expenses reasonably incurred by such
party in connection with investigating or defending any action or claim. The
provisions set forth in Section 7.3.3 with respect to the notice of the threat
or commencement of any threat or action shall apply if a claim for contribution
is to be made under this Section 7.3.4; provided, however, that no additional
notice shall be required with respect to any threat or action for which notice

                                       17
<PAGE>   18

has been given under Section 7.3 for purposes of indemnification. The Company
and the Purchaser agree that it would not be just and equitable if contribution
pursuant to this Section 7.3 were determined solely by pro rata allocation or by
any other method of allocation which does not take account of the equitable
considerations referred to in this paragraph. Notwithstanding the provisions of
this Section 7.3, the Purchaser shall not be required to contribute any amount
in excess of the amount by which the Difference exceeds the amount of any
damages that the Purchaser has otherwise been required to pay by reason of such
untrue or alleged untrue statement or omission or alleged omission. No person
guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of
the Securities Act) shall be entitled to contribution from any person who was
not guilty of such fraudulent misrepresentation.

        7.4    TERMINATION OF CONDITIONS AND OBLIGATIONS

        The restrictions imposed by Section 5 or this Section 7 upon the
transferability of the Shares shall cease and terminate as to any particular
number of the Shares upon the passage of two years from the effective date of
the Registration Statement covering the Shares or at such time as an opinion of
counsel satisfactory in form and substance to the Company shall have been
rendered to the effect that such conditions are not necessary in order to comply
with the Securities Act.

        7.5    INFORMATION AVAILABLE

        So long as the Registration Statement is effective covering the resale
of Shares owned by the Purchaser, the Company will furnish to the Purchaser:

               (a) as soon as practicable after available (but in the case of
the Company's Annual Report to Shareholders, within 120 days after the end of
each fiscal year of the Company), one copy of

              (i)     its Annual Report to Shareholders (which Annual Report
                      shall contain financial statements audited in accordance
                      with generally accepted accounting principles by a
                      national firm of certified public accountants);

              (ii)    if not included in substance in the Annual Report to
                      Shareholders, its Annual Report on Form 10-K;

              (iii)   if not included in substance in its Quarterly Reports to
                      Shareholders, its quarterly reports on Form 10-Q; and

              (iv)    a full copy of the particular Registration Statement
                      covering the Shares (the foregoing, in each case,
                      excluding exhibits);

               (b) upon the request of the Purchaser, a reasonable number of
copies of the Prospectus to supply to any other party requiring the Prospectus.

                                       18
<PAGE>   19

        7.6    RULE 144 INFORMATION

        For two years after the date of this Agreement, the Company shall file
all reports required to be filed by it under the Securities Act, the Rules and
Regulations and the Exchange Act and shall take such further action to the
extent required to enable the Purchaser to sell the Shares pursuant to Rule 144
under the Securities Act (as such rule may be amended from time to time).

8.      BROKER'S FEE

        The Purchaser acknowledges that the Company intends to pay to Adams,
Harkness & Hill, Inc., the placement agent, a fee in respect of the sale of the
Shares to the Purchaser. Each of the parties to this Agreement hereby represents
that, on the basis of any actions and agreements by it, there are no other
brokers or finders entitled to compensation in connection with the sale of the
Shares to the Purchaser.

9.      NOTICES

        All notices, requests, consents and other communications under this
Agreement shall be in writing, shall be mailed by first-class registered or
certified airmail, confirmed facsimile or nationally recognized overnight
express courier postage prepaid, and shall be delivered as addressed as follows:

             (a)     if to the Company, to:    NeoRx Corporation
                                               410 West Harrison Street
                                               Seattle, WA  98119
                                               (206) 281-7001
                                               Attn:  Richard L. Anderson

                     with a copy to:           Perkins Coie LLP
                                               1201 Third Avenue, 48th Floor
                                               Seattle, Washington 98101
                                               Attention: Faith M. Wilson

or to such other person at such other place as the Company shall designate to
the Purchaser in writing; and

               (b) if to the Purchaser, at its address as set forth on the
signature page to this Agreement, or at such other address or addresses as may
have been furnished to the Company in writing.

        Such notice shall be deemed effectively given upon confirmation of
receipt by facsimile, one business day after deposit with such overnight courier
or three days after deposit of such registered or certified airmail with the
U.S. Postal Service, as applicable.

                                       19
<PAGE>   20

10.     MODIFICATION; AMENDMENT

        This Agreement may not be modified or amended except pursuant to an
instrument in writing signed by the Company and the Purchaser.

11.     TERMINATION

        This Agreement may be terminated as to the Purchaser, at the option of
the Purchaser, if the Closing has not occurred on or before thirty (30) days
from the date of this Agreement.

12.     EXPENSES

        Each party to this Agreement shall pay its own fees and expenses
incident to the negotiation, preparation and execution of this Agreement and
related documents (including legal and accounting fees and expenses).

13.     HEADINGS

        The headings of the various sections of this Agreement have been
inserted for convenience of reference only and shall not be deemed to be part of
this Agreement.

14.     SEVERABILITY

        If any provision contained in this Agreement should be held to be
invalid, illegal or unenforceable in any respect, the validity, legality and
enforceability of the remaining provisions contained in this Agreement shall not
in any way be affected or impaired thereby.

15.     GOVERNING LAW

        This Agreement shall be governed by and construed in accordance with the
laws of the state of Washington and the federal law of the United States of
America.

16.     COUNTERPARTS

        This Agreement may be executed in two or more counterparts, each of
which shall constitute an original, but all of which, when taken together, shall
constitute but one instrument, and shall become effective when one or more
counterparts have been signed by each party to this Agreement and delivered to
the other parties.

                            [Signature page follows]

                                       20
<PAGE>   21

        IN WITNESS WHEREOF, the parties to this Agreement have caused this
Agreement to be executed by their duly authorized representatives as of the day
and year first above written.

                                        NEORX CORPORATION

                                        By
                                           -------------------------------------
                                        Name:
                                              ----------------------------------
                                        Its:
                                             -----------------------------------

                                        PURCHASER:

                                        ----------------------------------------

                                        By
                                           -------------------------------------
                                        Its:
                                             -----------------------------------
                                        Address:
                                                --------------------------------

                                        ----------------------------------------

                                        ----------------------------------------

                                       21
<PAGE>   22

                                    EXHIBIT A

                                    PURCHASER

                  PURCHASER                      NUMBER OF SHARES

<PAGE>   23

                                   APPENDIX I

                                NEORX CORPORATION

                         STOCK CERTIFICATE QUESTIONNAIRE

        Pursuant to Section 3 of the Agreement, please provide us with the
following information:

1.      The exact name that your Shares are to be registered in (this is the
        name that will appear on your stock certificate(s)). You may use a
        nominee name if appropriate: ___________________________________

2.      The relationship between the Purchaser of the Shares and the Registered
        Holder listed in response to item 1 above:
        __________________________________

3.      The mailing address of the Registered Holder listed in response to item
        1 above:

        ___________________________________

        ___________________________________

        ___________________________________

        __________________________________

4.      The Social Security Number or Tax Identification Number of the
        Registered Holder listed in response to item 1 above:
        ___________________________________

<PAGE>   24

                                   APPENDIX II

                                NEORX CORPORATION

                      REGISTRATION STATEMENT QUESTIONNAIRE

        In connection with the preparation of the Registration Statement, please
provide us with the following information:

1.      Pursuant to the "Selling Shareholder" section of the Registration
        Statement, please state your or your organization's name exactly as it
        should appear in the Registration Statement:
        _______________________________________________________

2.      Please provide the number of shares that you or your organization will
        own immediately after Closing, including those Shares purchased by you
        or your organization pursuant to this Purchase Agreement and those
        shares purchased by you or your organization through other transactions:
        _______________________________________________________

3.      Have you or your organization had any position, office or other material
        relationship within the last three years with the Company or its
        affiliates? [ ] Yes  [ ] No

        If yes, please indicate the nature of any such relationships below:

        _______________________________________________________

        _______________________________________________________

        _______________________________________________________

        _______________________________________________________

<PAGE>   25

                                  APPENDIX III

                   PURCHASER'S CERTIFICATE OF SUBSEQUENT SALE

The undersigned, [an officer of, or other person duly authorized by]

________________________________________________________________________________
              [fill in official name of individual or institution]

hereby certifies that he/she/it is the Purchaser of the shares evidenced by the
attached certificate, and as such, sold such shares on [date] in accordance with
Registration Statement number ________________, and complied with the
requirement of delivering a current prospectus in connection with such sale.

Print or Type:

Name of Purchaser (Individual or Institution):

___________________________________________________________

Name of Individual representing Purchaser (if an Institution)

___________________________________________________________

Title of Individual representing Purchaser (if an Institution):

___________________________________________________________

Signature:

Individual Purchaser or Individual representing Purchaser:

___________________________________________________________

                                      -2-
<PAGE>   26
                                                                     EXHIBIT 4.1

                                NEORX CORPORATION

                            SHARE PURCHASE AGREEMENT

        SHARE PURCHASE AGREEMENT, dated as of April __, 2000, between NeoRx
Corporation, a Washington corporation (the "Company"), and the purchaser listed
on Schedule A attached hereto (the "Purchaser").

1.      AUTHORIZATION OF SALE OF THE SHARES

        Subject to the terms and conditions of this Agreement, the Company has
authorized the issuance and sale of up to 4,000,000 shares (the "Shares") of
common stock, par value $0.02 per share (the "Common Stock"), of the Company
(the "Offering.").

2.      AGREEMENT TO SELL AND PURCHASE THE SHARES

        2.1    PURCHASE AND SALE

        Subject to the terms and conditions of this Agreement, the Purchaser
agrees to purchase, and the Company agrees to sell and issue to the Purchaser,
at the Closing (as defined below), that number of Shares set forth opposite the
Purchaser's name on Schedule A attached hereto.

        2.2    PURCHASE PRICE

        The purchase price of each Share (the "Per Share Price") shall be
$11.00.

3.      DELIVERY OF THE SHARES AT THE CLOSING

               (a) The completion of the purchase and sale of the Shares (the
"Closing"), shall occur at the offices of Perkins Coie LLP, 1201 Third Avenue,
48th Floor, Seattle, Washington 98101, counsel to the Company, at 5:00 p.m. EST
on April __, 2000 or such other time and date as may be agreed by the parties.

               (b) At the Closing, the Company shall authorize its transfer
agent (the "Transfer Agent") to issue to the Purchaser one or more stock
certificates registered in the name of the Purchaser, or in such nominee name(s)
as designated by the Purchaser in writing, representing the number of Shares set
forth in Section 2 above and bearing an appropriate legend referring to the fact
that the Shares were sold in reliance upon the exemption from registration
provided by Section 4(2) of the Securities Act of 1933, as amended (the
"Securities Act"), and Rule 506 under the Securities Act. The Company will
deliver certificates representing the number of Shares set forth in Section 2
against delivery of payment for the Shares by the Purchaser via wire transfer to
Bank of America account number 1113703, routing number 125000024.

               (c) The Company's obligation to complete the purchase and sale of
the Shares shall be subject to the following conditions, any one or more of
which may be waived by the Company:

                                       1
<PAGE>   27

              (i)     receipt by the Company of same-day funds in the full
                      amount of the purchase price for the Shares being
                      purchased under this Agreement; and

              (ii)    the accuracy in all material respects of the
                      representations and warranties made by the Purchaser and
                      the fulfillment in all material respects of those
                      undertakings of the Purchaser to be fulfilled on or before
                      the Closing.

               (d) The Purchaser's obligation to accept delivery of such stock
certificates and to pay for the Shares evidenced by the certificates shall be
subject to the following conditions, any one or more of which may be waived by
the Purchaser:

              (i)     the representations and warranties made by the Company in
                      this Agreement shall be accurate in all material respects
                      and the undertakings of the Company shall have been
                      fulfilled in all material respects on or before the
                      Closing;

              (ii)    the Company shall have delivered to the Purchaser a
                      certificate executed by the president and chief operating
                      officer or other executive officer of the Company, dated
                      the Closing date, in form and substance reasonably
                      satisfactory to the Purchaser, to the effect that the
                      representations and warranties of the Company set forth in
                      Section 4 hereof are true and correct in all material
                      respects as of the date of this Agreement and as of the
                      Closing Date, and that the Company has complied with all
                      the agreements and satisfied all the conditions in this
                      Agreement on its part to be performed or satisfied on or
                      before the Closing date; and

              (iii)   the Company shall have obtained aggregate gross proceeds
                      of at least $11 million from the Offering on the Closing
                      date.

4.      REPRESENTATIONS AND WARRANTIES OF THE COMPANY

        The Company hereby represents and warrants to the Purchaser as follows:

        4.1    ORGANIZATION AND QUALIFICATION

        The Company has been duly incorporated and is validly existing as a
corporation in good standing under the laws of the state of Washington. The
Company has the corporate power and authority to own, lease and operate its
properties and to conduct its business as currently conducted and to enter into
and perform its obligations under this Agreement. The Company is duly qualified
as a foreign corporation to transact business and is in good standing in each
jurisdiction in which such qualification is required, whether by reason of the
ownership or leasing of property or the conduct of business, except where the
failure to so qualify would not, singly or in the aggregate, have a material
adverse effect on the condition, financial or otherwise, or the earnings,
assets, business affairs or business prospects of the Company.

                                       2
<PAGE>   28

        4.2    CAPITALIZATION

               (a) The authorized capital stock of the Company consists of
60,000,000 shares of Common Stock and 3,000,000 shares of Preferred Stock.

               (b) As of March 31, 2000, the issued and outstanding capital
stock of the Company consists of 21,811,808 shares of Common Stock and the
shares of Series 1 convertible exchangeable preferred stock described in
subsection (f) below. The shares of issued and outstanding capital stock of the
Company have been duly authorized and validly issued, are fully paid and
nonassessable and have not been issued in violation of or are not otherwise
subject to any preemptive or other similar rights.

               (c) The Company has reserved an aggregate of 4,250,000 shares of
Common Stock for issuance upon the exercise of stock options granted or
available for future grant under the Company's 1994 Stock Option Plan and its
1991 Stock Option Plan for Non-Employee Directors, of which options to purchase
an aggregate of 2,890,453 shares of Common Stock have been granted and are
outstanding and an aggregate of 572,184 shares were available for grant at March
31, 2000. The Company has proposed, subject to shareholder approval, to increase
the number of shares issuable under the 1994 Stock Option Plan by 500,000
shares.

               (d) The Company has reserved 305,000 shares of Common Stock for
issuance upon the exercise of outstanding warrants to purchase Common Stock.

               (e) The Company has reserved 250,000 shares of Common Stock for
issuance under its 1991 Restricted Stock Program, of which 194,000 remained
available for grant at March 31, 2000.

               (f) 208,240 shares of Series 1 Convertible Preferred Stock of the
Company were convertible into 236,636 shares of the Common Stock as of March 31,
2000.

               (g) The Company has $1,185,000 in principal of convertible
subordinated debentures outstanding, which will be retired in June 2000. The
debentures are convertible at the option of the holder into shares of Common
Stock at a conversion price of $25.80 per share, subject to adjustment under
certain conditions.

        With the exception of the foregoing, there are no outstanding
subscriptions, options, warrants, convertible or exchangeable securities or
other rights granted to or by the Company to purchase shares of Common Stock or
other securities of the Company, and there are no commitments, plans or
arrangements to issue any shares of Common Stock or any security convertible
into or exchangeable for Common Stock.

        4.3    ISSUANCE, SALE AND DELIVERY OF THE SHARES

               (a) The Shares have been duly authorized for issuance and sale to
the Purchaser pursuant to this Agreement and, when issued and delivered by the
Company pursuant to this Agreement against payment of the consideration set
forth in this Agreement, will be validly issued and fully paid and nonassessable
and free and clear of all pledges, liens and

                                       3
<PAGE>   29

encumbrances. The certificates evidencing the Shares are in due and proper form
under Washington law.

               (b) The issuance of the Shares is not subject to preemptive or
other similar rights. No further approval or authority of the shareholders or
the Board of Directors of the Company will be required for the issuance and sale
of the Shares to be sold by the Company as contemplated in this Agreement.
Except for shareholders who purchase Shares in the Offering, no shareholder of
the Company has any right (other than any right that has been waived following
notification of the Company's intent to file the Registration Statement (as
hereinafter defined) or has expired by reason of lapse of time) to require the
Company to register the sale of any securities owned by such holder in such
Registration Statement.

               (c) Subject to the accuracy of the Purchaser's representations
and warranties in Section 5 of this Agreement, the offer, sale, and issuance of
the Shares in conformity with the terms of this Agreement constitute
transactions exempt from the registration requirements of Section 5 of the
Securities Act and from the registration or qualification requirements of the
laws of any applicable state or United States jurisdiction.

        4.4    FINANCIAL STATEMENTS

        The financial statements included in the Company Documents (as
hereinafter defined) present fairly the financial position of the Company as of
the dates indicated and the results of their operations for the periods
specified. Except as otherwise stated in such Company Documents, such financial
statements have been prepared in conformity with generally accepted accounting
principles applied on a consistent basis, and any supporting schedules included
with the financial statements present fairly the information stated in the
financial statements. The financial and statistical data set forth in the
Company Documents were prepared on an accounting basis consistent with such
financial statements.

        4.5    NO MATERIAL CHANGE

        Since December 31, 1999,

               (a) there has been no material adverse change or any development
involving a prospective material adverse change in or affecting the condition,
financial or otherwise, or in the earnings, assets, business affairs or business
prospects of the Company, whether or not arising in the ordinary course of
business;

               (b) there have been no transactions entered into by the Company
other than those in the ordinary course of business, which are material with
respect to the Company; and

               (c) there has been no dividend or distribution of any kind
declared, paid or made by the Company on any class of its capital stock, except
for the approval by the Board of Directors of the payment of the Series 1
Preferred Stock dividend of $1.21875 per share, payable on June 1, 2000 for
shareholders of record on May 19, 2000.

        The Company has no material contingent obligations.

                                       4
<PAGE>   30

        4.6    ENVIRONMENTAL

        Except as would not, singly or in the aggregate, reasonably be expected
to have a material adverse effect on the condition, financial or otherwise, or
the earnings, assets, business affairs or business prospects of the Company,

               (a) the Company is in compliance with all applicable
Environmental Laws (as defined below);

               (b) the Company has all permits, authorizations and approvals
required under any applicable Environmental Laws and is in compliance with the
requirements of such permits authorizations and approvals; and

               (c) there are no pending or, to the best knowledge of the
Company, threatened Environmental Claims against the Company.

        For purposes of this Agreement, the following terms shall have the
following meanings: "Environmental Law" means any United States (or other
applicable jurisdiction's) Federal, state, local or municipal statute, law,
rule, regulation, ordinance, code, policy or rule of common law and any judicial
or administrative interpretation thereof, including any judicial or
administrative order, consent decree or judgment, relating to the environment,
health, safety or any chemical, material or substance, exposure to which is
prohibited, limited or regulated by any governmental authority. "Environmental
Claims" means any administrative, regulatory or judicial actions, suits,
demands, demand letters, claims, liens, notices of noncompliance or violation,
investigations or proceedings relating to any Environmental Law.

        4.7    NO DEFAULTS

        The Company is not in violation of its articles of incorporation or
bylaws or in material default in the performance or observance of any
obligation, agreement, covenant or condition contained in any material contract,
indenture, mortgage, loan agreement, deed, trust, note, lease, sublease, voting
agreement, voting trust, or other instrument or agreement to which the Company
is a party or by which it may be bound, or to which any of the property or
assets of the Company is subject.

        4.8    LABOR MATTERS

        No labor dispute with the employees of the Company exists or, to the
best knowledge of the Company, is imminent.

        4.9    NO ACTIONS

        There is no action, suit or proceeding before or by any court or
governmental agency or body, domestic or foreign, now pending, or, to the
knowledge of the Company, threatened, against or affecting the Company which,
singly or in the aggregate, would result in any material adverse change in the
condition, financial or otherwise, or in the earnings, business affairs or
business prospects of the Company, or which, singly or in the aggregate, would
materially and

                                       5
<PAGE>   31

adversely affect the properties or assets thereof or which would materially and
adversely affect the consummation of this Agreement, nor, to the best knowledge
of the Company, is there any reasonable basis therefor. The Company is not in
default with respect to any judgment, order or decree of any court or
governmental agency or instrumentality which, singly or in the aggregate, would
have a material adverse effect on the assets, properties or business of the
Company.

        4.10   INTELLECTUAL PROPERTY

               (a) The Company, to the best of its knowledge, owns or is
licensed to use all patents, patent applications, inventions, trademarks, trade
names, applications for registration of trademarks, service marks, service mark
applications, copyrights, know-how, manufacturing processes, formulae, trade
secrets, licenses and rights in any thereof and any other intangible property
and assets (in this Agreement called the "Proprietary Rights") that are material
to the business of the Company as now conducted and as proposed to be conducted.

               (b) The Company does not have any knowledge of, and the Company
has not given or received any notice of, any pending conflicts with or
infringement of the rights of others with respect to any Proprietary Rights or
with respect to any license of Proprietary Rights which are material to the
business of the Company.

               (c) No action, suit, arbitration, or legal, administrative or
other proceeding, or investigation is pending, or, to the best knowledge of the
Company, threatened, which involves any Proprietary Rights, nor, to the best
knowledge of the Company, is there any reasonable basis therefor.

               (d) The Company is not subject to any judgment, order, writ,
injunction or decree of any court or any Federal, state, local, foreign or other
governmental department, commission, board, bureau, agency or instrumentality,
domestic or foreign, or any arbitrator, and has not entered into or is not a
party to any contract which restricts or impairs the use of any such Proprietary
Rights in a manner which would have a material adverse effect on the use of any
of the Proprietary Rights.

               (e) No Proprietary Rights used by the Company, and no services or
products sold by the Company, conflict with or infringe upon any proprietary
rights of any third party. The Company has not received written notice of any
pending conflict with or infringement upon such third-party proprietary rights.

               (f) The Company has not entered into any consent,
indemnification, forbearance to sue or settlement agreement with respect to
Proprietary Rights other than in the ordinary course of business. No claims have
been asserted by any person with respect to the validity of the Company's
ownership or right to use the Proprietary Rights and, to the best knowledge of
the Company, there is no reasonable basis for any such claim to be successful.

               (g) The Proprietary Rights that are material to the business of
the Company are valid and enforceable and no registration relating thereto has
lapsed, expired or been abandoned or cancelled or is the subject of cancellation
or other adversarial proceedings, and all applications therefor are pending and
are in good standing.

                                       6
<PAGE>   32

               (h) To the best of its knowledge, the Company has complied, in
all material respects, with its obligations relating to the protection of the
Proprietary Rights which are material to the business of the Company used
pursuant to licenses.

               (i) To the best knowledge of the Company, no person is infringing
on or violating the Proprietary Rights.

        4.11   PERMITS

        The Company possesses and is operating in compliance with all material
licenses, certificates, consents, authorities, approvals and permits from all
state, Federal, foreign and other regulatory agencies or bodies necessary to
conduct the businesses now operated by it, and the Company has not received any
notice of proceedings relating to the revocation or modification of any such
permit or any circumstance which would lead it to believe that such proceedings
are reasonably likely which, singly or in the aggregate, if the subject of an
unfavorable decision, ruling or finding, would materially and adversely affect
the condition, financial or otherwise, or the earnings, assets, business affairs
or business prospects of the Company.

        4.12   DUE EXECUTION, DELIVERY AND PERFORMANCE

               (a) This Agreement has been duly executed and delivered by the
Company and constitutes a valid and binding obligation of the Company,
enforceable against the Company in accordance with its terms, except as rights
to indemnity and contribution under this Agreement may be limited by Federal or
state securities laws or the public policy underlying such laws.

               (b) The execution, delivery and performance of this Agreement and
the consummation of the transactions contemplated in this Agreement and the
fulfillment of the terms of this Agreement have been duly authorized by all
necessary corporate action and will not conflict with or constitute a breach of,
or default under, or result in the creation or imposition of any lien, charge or
encumbrance upon any property or assets of the Company pursuant to, any
contract, indenture, mortgage, loan agreement, deed, trust, note, lease,
sublease, voting agreement, voting trust or other instrument or agreement to
which the Company is a party or by which it may be bound, or to which any of the
property or assets of the Company is subject, nor will such action result in any
violation of the provisions of the articles of incorporation or bylaws of the
Company or any applicable statute, law, rule, regulation, ordinance, decision,
directive or order.

        4.13   PROPERTIES

        The Company has good and marketable title to its properties, free and
clear of all material security interests, mortgages, pledges, liens, charges,
encumbrances and claims of record. The properties of the Company are, in the
aggregate, in good repair (reasonable wear and tear excepted), and suitable for
their respective uses. Any real property held under lease by the Company is held
under valid, subsisting and enforceable leases with such exceptions as are not
material and do not interfere with the conduct of the business of the Company.
The Company owns or leases all such properties as are necessary to its business
or operations as now conducted.

                                       7
<PAGE>   33

        4.14   COMPLIANCE

        The Company has conducted and is conducting its business in compliance
with all applicable Federal, state, local and foreign statutes, laws, rules,
regulations, ordinances, codes, decisions, decrees, directives and orders,
except where the failure to do so would not, singly or in the aggregate, have a
material adverse effect on the condition, financial or otherwise, or on the
earnings, assets, business affairs or business prospects of the Company.

        4.15   SECURITY MEASURES

        The Company takes security measures designed to enable the Company to
assert trade secret protection in its non-patented technology.

        4.16   CONTRIBUTIONS

        To the best of the Company's knowledge, neither the Company nor any
employee or agent of the Company has made any payment of funds of the Company or
received or retained any funds in violation of any law, rule or regulation.

        4.17   USE OF PROCEEDS; INVESTMENT COMPANY

        The Company intends to use the net proceeds from the sale of the Shares
for research and development, pre-launch activities, general corporate purposes
and working capital. The Company is not now, and after the sale of the Shares
under this Agreement and under all other agreements and the application of the
net proceeds from the sale of the Shares described in the preceding sentence
will not be, an "investment company" within the meaning of the Investment
Company Act of 1940, as amended.

        4.18   PRIOR OFFERINGS

        All offers and sales of capital stock of the Company before the date of
this Agreement were at all relevant times duly registered or exempt from the
registration requirements of the Securities Act and were duly registered or
subject to an available exemption from the registration requirements of the
applicable state securities or Blue Sky laws.

        4.19   TAXES

        The Company has filed all material tax returns required to be filed,
which returns are true and correct in all material respects, and the Company is
not in default in the payment of any taxes, including penalties and interest,
assessments, fees and other charges, shown thereon due or otherwise assessed,
other than those being contested in good faith and for which adequate reserves
have been provided or those currently payable without interest which were
payable pursuant to said returns or any assessments with respect thereto.

                                       8
<PAGE>   34

        4.20   OTHER GOVERNMENTAL PROCEEDINGS

        To the Company's knowledge, there are no rulemaking or similar
proceedings before The United States Food and Drug Administration or comparable
Federal, state, local or foreign government bodies that involve or affect the
Company, which, if the subject of an action unfavorable to the Company, would
reasonably be expected to materially and adversely affect the condition,
financial or otherwise, or the earnings, assets, business affairs or business
prospects of the Company.

        4.21   NON-COMPETITION AGREEMENTS

        To the knowledge of the Company, any full-time employee who has entered
into any non-competition, non-disclosure, confidentiality or other similar
agreement with any party other than the Company is neither in violation of nor
is expected to be in violation of that agreement as a result of the business
currently conducted or expected to be conducted by the Company or such person's
performance of his or her obligations to the Company. The Company has not
received written notice that any consultant or scientific advisor of the Company
is in violation of any non-competition, non-disclosure, confidentiality or
similar agreement.

        4.22   TRANSFER TAXES

        On the Closing date, all stock transfer or other taxes (other than
income taxes) that are required to be paid in connection with the sale and
transfer of the Shares to be sold to the Purchaser under this Agreement will be,
or will have been, fully paid or provided for by the Company and all laws
imposing such taxes will be or will have been fully complied with.

        4.23   INSURANCE

        The Company maintains insurance of the type and in the amount that the
Company reasonably believes is adequate for its business, including, but not
limited to, insurance covering all real and personal property owned or leased by
the Company against theft, damage, destruction, acts of vandalism and all other
risks customarily insured against by similarly situated companies, all of which
insurance is in full force and effect.

        4.24   GOVERNMENTAL CONSENTS

        No registration, authorization, approval, qualification or consent of
any court or governmental authority or agency is necessary in connection with
the execution and delivery of this Agreement or the offering, issuance or sale
of the Shares under this Agreement, except such as may be required under the
Securities Act or the rules and regulations promulgated thereunder or state
securities or Blue Sky laws, or such as may be required by the National
Association of Securities Dealers, Inc.

                                       9
<PAGE>   35

        4.25   SECURITIES AND EXCHANGE COMMISSION FILINGS

        The Company has timely filed with the Securities and Exchange Commission
(the "Commission") all documents required to be filed by the Company under the
Exchange Act of 1934, as amended (the "Exchange Act.")

        4.26   ADDITIONAL INFORMATION

        The Company represents and warrants that the information contained in
the following documents (the "Company Documents"), which will be provided to
Purchaser before the Closing, is or will be true and correct in all material
respects as of their respective final dates:

               (a) the Company's Annual Report on Form 10-K for the fiscal year
ended December 31, 1999;

               (b) the Company's Quarterly Reports on Form 10-Q for the fiscal
quarters ended March 31, 1999, June 30, 1999 and September 30, 1999;

               (c) the Company's Proxy Statement for its 1999 Annual Meeting of
Shareholders; and

               (d) all other documents, if any, filed by the Company with the
Commission since January 1, 1999 pursuant to the reporting requirements of the
Exchange Act.

        4.27   CONTRACTS

        The contracts described in the Company Documents or incorporated by
reference therein are in full force and effect on the date hereof, except for
contracts the termination or expiration of which would not, singly or in the
aggregate, have a material adverse effect on the business, properties or assets
of the Company. Neither the Company nor, to the best knowledge of the Company,
any other party is in breach of or default under any such contracts.

5.      REPRESENTATIONS, WARRANTIES AND COVENANTS OF THE PURCHASER

        5.1    SECURITIES LAW REPRESENTATIONS AND WARRANTIES

        The Purchaser represents, warrants and covenants to the Company as
follows:

               (a) The Purchaser is knowledgeable, sophisticated and experienced
in making, and is qualified to make, decisions with respect to investments in
shares representing an investment decision like that involved in the purchase of
the Shares, including investments in securities issued by the Company, and has
requested, received, reviewed and considered all information it deems relevant
in making an informed decision to purchase the Shares.

               (b) The Purchaser is acquiring the number of Shares set forth in
Section 2 above in the ordinary course of its business and for its own account
for investment (as defined for purposes of the Hart-Scott-Rodino Antitrust
Improvement Act of 1976 and the regulations thereunder) only, and has no present
intention of distributing any of the Shares nor any

                                       10
<PAGE>   36

arrangement or understanding with any other persons regarding the distribution
of such Shares within the meaning of Section 2(11) of the Securities Act, other
than as contemplated in Section 7 of this Agreement.

               (c) The Purchaser will not, directly or indirectly, offer, sell,
pledge, transfer or otherwise dispose of (or solicit any offers to buy, purchase
or otherwise acquire or take a pledge of) any of the Shares except in compliance
with the Securities Act and the Rules and Regulations.

               (d) The Purchaser has completed or caused to be completed the
Stock Certificate Questionnaire and the Registration Statement Questionnaire,
attached to this Agreement as Appendices I and II, for use in preparation of the
Registration Statement (as defined in Section 7.3 below), and the answers to the
Questionnaires are true and correct as of the date of this Agreement and will be
true and correct as of the effective date of the Registration Statement;
provided that the Purchaser shall be entitled to update such information by
providing notice thereof to the Company before the effective date of such
Registration Statement.

               (e) The Purchaser has, in connection with its decision to
purchase the number of Shares set forth in Section 2 above, relied solely upon
the Company Documents and the representations and warranties of the Company
contained in this Agreement.

               (f) The Purchaser is an "accredited investor" within the meaning
of Rule 501 of Regulation D promulgated under the Securities Act.

        5.2    RESALES OF SHARES

               (a) The Purchaser hereby covenants with the Company not to make
any sale of the Shares without satisfying the requirements of the Securities Act
and the Rules and Regulations, including, in the event of any resale under the
Registration Statement, the prospectus delivery requirements under the
Securities Act, and the Purchaser acknowledges and agrees that such Shares are
not transferable on the books of the Company pursuant to a resale under the
Registration Statement unless the certificate submitted to the transfer agent
evidencing the Shares is accompanied by a separate officer's certificate:

              (i)     in the form of Appendix III to this Agreement;

              (ii)    executed by an officer of, or other authorized person
                      designated by, the Purchaser, and

              (iii)   to the effect that (A) the Shares have been sold in
                      accordance with the Registration Statement and (B) the
                      requirement of delivering a current prospectus has been
                      satisfied.

               (b) The Purchaser acknowledges that there may occasionally be
times when the Company determines the use of the prospectus forming a part of
the Registration Statement (the "Prospectus," as further defined in Section
7.3.1 below) should be suspended until such time as an amendment or supplement
to the Registration Statement or the Prospectus has been filed by

                                       11
<PAGE>   37

the Company and any such amendment to the Registration Statement is declared
effective by the Commission, or until such time as the Company has filed an
appropriate report with the Commission pursuant to the Exchange Act. The
Purchaser hereby covenants that it will not sell any Shares pursuant to the
Prospectus during the period commencing at the time at which the Company gives
the Purchaser written notice of the suspension of the use of the Prospectus and
ending at the time the Company gives the Purchaser written notice that the
Purchaser may thereafter effect sales pursuant to the Prospectus. The Company
may, upon written notice to the Purchaser, suspend the use of the Prospectus for
two 30-day periods in any 365-day period based on the reasonable determination
of the Company's Board of Directors that there is a significant business purpose
for such determination, such as pending corporate developments, public filings
with the SEC or similar events. The Company shall in no event be required to
disclose the business purpose for which it has suspended the use of the
Prospectus if the Company determines in its good faith judgment that the
business purpose should remain confidential.

        5.3    DUE EXECUTION, DELIVERY AND PERFORMANCE

               (a) This Agreement has been duly executed and delivered by the
Purchaser and constitutes a valid and binding obligation of the Purchaser,
enforceable against the Purchaser in accordance with its terms, except as rights
to indemnity and contribution under this Agreement may be limited by Federal or
state securities laws or the public policy underlying such laws.

               (b) The execution, delivery and performance of this Agreement and
the consummation of the transactions contemplated in this Agreement and the
fulfillment of the terms of this Agreement have been duly authorized by all
necessary corporate action and will not conflict with or constitute a breach of,
or default under, or result in the creation or imposition of any lien, charge or
encumbrance upon any property or assets of the Purchaser pursuant to, any
contract, indenture, mortgage, loan agreement, deed, trust, note, lease,
sublease, voting agreement, voting trust or other instrument or agreement to
which the Purchaser is a party or by which it or any of them may be bound, or to
which any of the property or assets of the Purchaser is subject, nor will such
action result in any violation of the provisions of the charter or bylaws of the
Purchaser or any applicable statute, law, rule, regulation, ordinance, decision,
directive or order.

6.      SURVIVAL OF REPRESENTATIONS, WARRANTIES AND AGREEMENTS.

        Notwithstanding any investigation made by any party to this Agreement,
all covenants, agreements, representations and warranties made by the Company
and the Purchaser in this Agreement and in the certificates for the Shares
delivered pursuant to this Agreement shall survive for a period of two years
following the execution of this Agreement, the delivery to the Purchaser of the
Shares being purchased and the payment therefor.

                                       12
<PAGE>   38

7.      REGISTRATION; COMPLIANCE WITH THE SECURITIES ACT

        7.1    REGISTRATION OF SHARES

               7.1.1  REGISTRATION STATEMENT; EXPENSES

        The Company shall use its best efforts to:

               (a) Within five (5) business days after the Closing, prepare and
file with the Commission a Registration Statement on Form S-3 relating to the
sale of the Shares by the Purchaser from time to time on the Nasdaq National
Market (or the facilities of any national securities exchange on which the
Company's Common Stock is then traded) or in privately negotiated transactions
(the "Registration Statement");

               (b) subject to receipt of necessary information from the
Purchaser, to cause the Commission to notify the Company of the Commission's
willingness to declare the Registration Statement effective within 90 days after
the Closing, immediately notify the Purchaser of such effectiveness, and furnish
to the Purchaser one copy of the current prospectus within five business days of
effectiveness of the Registration Statement;

               (c) prepare and file with the Commission such amendments and
supplements to the Registration Statement and the Prospectus (as defined in
Section 7.3.1 below) and take such other action, if any, as may be necessary to
keep the Registration Statement effective until the earlier of (i) two years
after the effective date of the Registration Statement, (ii) the date on which
the Shares may be resold by the Purchaser without registration or without regard
to any volume limitations by reason of Rule 144(k) under the Securities Act or
any other rule of similar effect or (iii) all of the Shares have been sold
pursuant to the Registration Statement or Rule 144(k) under the Securities Act
or any other rule of similar effect;

               (d) furnish to the Purchaser with respect to the Shares
registered under the Registration Statement such reasonable number of copies of
the Prospectus, including any supplements to or amendments of the Prospectus, in
order to facilitate the public sale or other disposition of all or any of the
Shares by the Purchaser;

               (e) during the period when copies of the Prospectus are required
to be delivered under the Securities Act or the Exchange Act, will file all
documents required to be filed with the Commission pursuant to Section 13, 14 or
15 of the Exchange Act within the time periods required by the Exchange Act and
the rules and regulations promulgated thereunder;

               (f) file documents required of the Company for customary Blue Sky
clearance in states specified in writing by the Purchaser; provided, however,
that the Company shall not be required to qualify to do business or consent to
service of process in any jurisdiction in which it is not now so qualified or
has not so consented; and

               (g) bear all expenses in connection with the procedures in
paragraphs (a) through (f) of this Section 7.1.1 and the registration of the
Shares pursuant to the Registration

                                       13
<PAGE>   39

Statement, other than any fees and expenses of counsel or other advisers to the
Purchaser, brokerage fees and commissions incurred by the Purchaser.

        The Purchaser acknowledges and agrees that the Registration Statement
filed under this Section, in addition to the Shares held by the Purchaser, shall
include Shares held by other purchasers in the Offering and, at the Company's
election, may include shares of Common Stock held by other Company shareholders
or issuable under any warrants, options or convertible securities.

               7.1.2  DELAY IN EFFECTIVENESS OF REGISTRATION STATEMENT

        In the event that the Registration Statement is not declared effective
within 90 days after the Closing, the Company shall pay to the Purchaser
liquidated damages in an amount equal to 0.25% of the number of Shares purchased
by the Purchaser pursuant to this Agreement for each week thereafter that the
Registration Statement is not declared effective. Such liquidated damages shall
be paid through the issuance of additional Shares at such time as the
Registration Statement is declared effective. No liquidated damages shall be
paid under this Agreement if effectiveness of the Registration Statement is
prevented or delayed due to fire, explosion, flood, riot, labor dispute,
accident, act of God, change in existing regulation or law, or other similar
event beyond the Company's reasonable control.

        7.2    TRANSFER OF SHARES AFTER REGISTRATION

        The Purchaser agrees that it will not effect any disposition of the
Shares or its right to purchase the Shares that would constitute a sale within
the meaning of the Securities Act, except as contemplated in the Registration
Statement referred to in Section 7.1 or as otherwise permitted by law, and that
it will promptly notify the Company of any changes in the information set forth
in the Registration Statement regarding the Purchaser or its plan of
distribution.

        7.3    INDEMNIFICATION

        For the purpose of this Section 7.3, the term "Registration Statement"
shall include any preliminary or final prospectus, exhibit, supplement or
amendment included in or relating to the Registration Statement referred to in
Section 7.1.

               7.3.1  INDEMNIFICATION BY THE COMPANY

        The Company agrees to indemnify and hold harmless the Purchaser and each
person, if any, who controls the Purchaser within the meaning of the Securities
Act, against any losses, claims, damages, liabilities or expenses, joint or
several, to which the Purchaser or such controlling person may become subject,
under the Securities Act, the Exchange Act, or any other federal or state
statutory law or regulation, or at common law or otherwise (including in
settlement of any litigation, if such settlement is effected with the written
consent of the Company, which consent shall not be unreasonably withheld),
insofar as such losses, claims, damages, liabilities or expenses (or actions in
respect thereof as contemplated below) arise out of or are based upon any untrue
statement or alleged untrue statement of any material fact contained in the
Registration Statement, including the Prospectus, financial statements and
schedules, and

                                       14
<PAGE>   40

all other documents filed as a part thereof, as amended at the time of
effectiveness of the Registration Statement, including any information deemed to
be a part thereof as of the time of effectiveness pursuant to paragraph (b) of
Rule 430A, or pursuant to Rule 434, of the Rules and Regulations, or the
Prospectus, in the form first filed with the Commission pursuant to Rule 424(b)
of the Regulations, or filed as part of the Registration Statement at the time
of effectiveness if no Rule 424(b) filing is required (the "Prospectus"), or any
amendment or supplement thereto, or arise out of or are based upon the omission
or alleged omission to state in any of them a material fact required to be
stated therein or necessary to make the statements in any of them, in light of
the circumstances under which they were made, not misleading, or arise out of or
are based in whole or in part on any inaccuracy in the representations and
warranties of the Company contained in this Agreement, or any failure of the
Company to perform its obligations under this Agreement or under law, and will
reimburse the Purchaser and each such controlling person for any legal and other
expenses as such expenses are reasonably incurred by the Purchaser or such
controlling person in connection with investigating, defending, settling,
compromising or paying any such loss, claim, damage, liability, expense or
action; provided, however, that the Company will not be liable in any such case
to the extent that any such loss, claim, damage, liability or expense arises out
of or is based upon (i) an untrue statement or alleged untrue statement or
omission or alleged omission made in the Registration Statement, the Prospectus
or any amendment or supplement of the Registration Statement or Prospectus in
reliance upon and in conformity with written information furnished to the
Company by or on behalf of the Purchaser expressly for use in the Registration
Statement or the Prospectus, or (ii) any untrue statement or omission of a
material fact required to make such statement not misleading in any Prospectus
that is corrected in any subsequent Prospectus that was delivered to the
Purchaser before the pertinent sale or sales by the Purchaser.

               7.3.2  INDEMNIFICATION BY THE PURCHASER

        The Purchaser will indemnify and hold harmless the Company, each of its
directors, each of its officers who signed the Registration Statement and each
person, if any, who controls the Company within the meaning of the Securities
Act, against any losses, claims, damages, liabilities or expenses to which the
Company, each of its directors, each of its officers who signed the Registration
Statement or controlling person may become subject, under the Securities Act,
the Exchange Act, or any other federal or state statutory law or regulation, or
at common law or otherwise (including in settlement of any litigation, if such
settlement is effected with the written consent of the Purchaser, which consent
shall not be unreasonably withheld) insofar as such losses, claims, damages,
liabilities or expenses (or actions in respect thereof as contemplated below)
arise out of or are based upon any untrue or alleged untrue statement of any
material fact contained in the Registration Statement, the Prospectus, or any
amendment or supplement to the Registration Statement or Prospectus, or arise
out of or are based upon the omission or alleged omission to state therein a
material fact required to be stated therein or necessary to make the statements
therein not misleading, in each case to the extent, but only to the extent, that
such untrue statement or alleged untrue statement or omission or alleged
omission was made in the Registration Statement, the Prospectus, or any
amendment or supplement thereto, in reliance upon and in conformity with written
information furnished to the Company by or on behalf of the Purchaser expressly
for use therein, and the Purchaser will reimburse the Company, each of its
directors, each of its officers who signed the Registration Statement or

                                       15
<PAGE>   41

controlling person for any legal and other expense reasonably incurred by the
Company, each of its directors, each of its officers who signed the Registration
Statement or controlling person in connection with investigating, defending,
settling, compromising or paying any such loss, claim, damage, liability,
expense or action. Notwithstanding the foregoing, the Purchaser shall not be
liable for any indemnification obligation hereunder in excess of the net
proceeds received by such Purchaser in respect of the Shares.

               7.3.3  INDEMNIFICATION PROCEDURE

               (a) Promptly after receipt by an indemnified party under this
Section 7.3 of notice of the threat or commencement of any action, such
indemnified party will, if a claim in respect thereof is to be made against an
indemnifying party under this Section 7.3, promptly notify the indemnifying
party in writing of the claim; but the omission so to notify the indemnifying
party will not relieve it from any liability which it may have to any
indemnified party for contribution or otherwise than under the indemnity
agreement contained in this Section 7.3 or to the extent it is not prejudiced as
a result of such failure.

               (b) In case any such action is brought against any indemnified
party and such indemnified party seeks or intends to seek indemnity from an
indemnifying party, the indemnifying party will be entitled to participate in,
and, to the extent that it may wish, jointly with all other indemnifying parties
similarly notified, to assume the defense thereof with counsel reasonably
satisfactory to such indemnified party; provided, however, if the defendants in
any such action include both the indemnified party and the indemnifying party
and the indemnified party shall have reasonably concluded that there may be a
conflict between the positions of the indemnifying party and the indemnified
party in conducting the defense of any such action or that there may be legal
defenses available to it or other indemnified parties that are different from or
additional to those available to the indemnifying party, the indemnified party
or parties shall have the right to select separate counsel to assume such legal
defenses and to otherwise participate in the defense of such action on behalf of
such indemnified party or parties. Upon receipt of notice from the indemnifying
party to such indemnified party of its election so to assume the defense of such
action and approval by the indemnified party of counsel, the indemnifying party
will not be liable to such indemnified party under this Section 7.3 for any
legal or other expenses subsequently incurred by such indemnified party in
connection with the defense thereof unless:

              (i)     the indemnified party shall have employed such counsel in
                      connection with the assumption of legal defenses in
                      accordance with the proviso to the preceding sentence (it
                      being understood, however, that the indemnifying party
                      shall not be liable for the expenses of more than one
                      separate counsel, approved by such indemnifying party in
                      the case of paragraph (a), representing all of the
                      indemnified parties who are parties to such action) or

              (ii)    the indemnifying party shall not have employed counsel
                      reasonably satisfactory to the indemnified party to
                      represent the indemnified party within a reasonable time
                      after notice of commencement of action, in each

                                       16
<PAGE>   42

                      of which cases the reasonable fees and expenses of counsel
                      shall be at the expense of the indemnifying party.

               7.3.4  CONTRIBUTION

               If the indemnification provided for in this Section 7.3 is
required by its terms but is for any reason held by a court of competent
jurisdiction to be unavailable to hold harmless an indemnified party under this
Section 7.3 in respect to any losses, claims, damages, liabilities or expenses
referred to in this Agreement, then each applicable indemnifying party shall
contribute to the amount paid or payable by such indemnified party as a result
of any losses, claims, damages, liabilities or expenses referred to in this
Agreement in such proportion as is appropriate to reflect the relative fault of
the Company and the Purchaser in connection with the statements or omissions or
inaccuracies in the representations and warranties in this Agreement that
resulted in such losses, claims, damages, liabilities or expenses, as well as
any other relevant equitable considerations.

        The relative fault of the Company and the Purchaser shall be determined
by reference to, among other things, whether the untrue or alleged statement of
a material fact or the omission or alleged omission to state a material fact or
the inaccurate or the alleged inaccurate representation or warranty relates to
information supplied by the Company or by the Purchaser and the parties'
relative intent, knowledge, access to information and opportunity to correct or
prevent such statement or omission. The amount paid or payable by a party as a
result of the losses, claims, damages, liabilities and expenses referred to
above shall be deemed to include, subject to the limitations set forth in
Section 7.3.3, any legal or other fees or expenses reasonably incurred by such
party in connection with investigating or defending any action or claim. The
provisions set forth in Section 7.3.3 with respect to the notice of the threat
or commencement of any threat or action shall apply if a claim for contribution
is to be made under this Section 7.3.4; provided, however, that no additional
notice shall be required with respect to any threat or action for which notice
has been given under Section 7.3 for purposes of indemnification. The Company
and the Purchaser agree that it would not be just and equitable if contribution
pursuant to this Section 7.3 were determined solely by pro rata allocation or by
any other method of allocation which does not take account of the equitable
considerations referred to in this paragraph. Notwithstanding the provisions of
this Section 7.3, the Purchaser shall not be required to contribute any amount
in excess of the net proceeds received by the Purchaser in respect of the
Shares.. No person guilty of fraudulent misrepresentation (within the meaning of
Section 11(f) of the Securities Act) shall be entitled to contribution from any
person who was not guilty of such fraudulent misrepresentation.

        7.4    TERMINATION OF CONDITIONS AND OBLIGATIONS

        The restrictions imposed by Section 5 or this Section 7 upon the
transferability of the Shares shall cease and terminate as to any particular
number of the Shares upon the passage of two years from the effective date of
the Registration Statement covering the Shares or at such time as an opinion of
counsel satisfactory in form and substance to the Company shall have been
rendered to the effect that such conditions are not necessary in order to comply
with the Securities Act.

                                       17
<PAGE>   43

        7.5    INFORMATION AVAILABLE

        So long as the Registration Statement is effective covering the resale
of Shares owned by the Purchaser, the Company will furnish to the Purchaser:

               (a) as soon as practicable after available (but in the case of
the Company's Annual Report to Shareholders, within 120 days after the end of
each fiscal year of the Company), one copy of

              (i)     its Annual Report to Shareholders (which Annual Report
                      shall contain financial statements audited in accordance
                      with generally accepted accounting principles by a
                      national firm of certified public accountants);

              (ii)    if not included in substance in the Annual Report to
                      Shareholders, its Annual Report on Form 10-K;

              (iii)   if not included in substance in its Quarterly Reports to
                      Shareholders, its quarterly reports on Form 10-Q; and

              (iv)    a full copy of the particular Registration Statement
                      covering the Shares (the foregoing, in each case,
                      excluding exhibits);

               (b) upon the request of the Purchaser, a reasonable number of
copies of the Prospectus to supply to any other party requiring the Prospectus.

        7.6    RULE 144 INFORMATION

        For two years after the date of this Agreement, the Company shall file
all reports required to be filed by it under the Securities Act, the Rules and
Regulations and the Exchange Act and shall take such further action to the
extent required to enable the Purchaser to sell the Shares pursuant to Rule 144
under the Securities Act (as such rule may be amended from time to time).

8.      BROKER'S FEE

        The Purchaser acknowledges that the Company intends to pay to Adams,
Harkness & Hill, Inc., the placement agent, a fee in respect of the sale of the
Shares to the Purchaser. Each of the parties to this Agreement hereby represents
that, on the basis of any actions and agreements by it, there are no other
brokers or finders entitled to compensation in connection with the sale of the
Shares to the Purchaser.

9.      NOTICES

        All notices, requests, consents and other communications under this
Agreement shall be in writing, shall be mailed by first-class registered or
certified airmail, facsimile (with telephonic confirmation) or nationally
recognized overnight express courier postage prepaid, and shall be delivered as
addressed as follows:

                                       18
<PAGE>   44

                                               NeoRx Corporation
                                               410 West Harrison Street
             (a)     if to the Company, to:    Seattle, WA  98119
                                               (206) 281-7001
                                               Attn:  Richard L. Anderson

                     with a copy to:           Perkins Coie LLP
                                               1201 Third Avenue, 48th Floor
                                               Seattle, Washington 98101
                                               Attention: Faith M. Wilson

or to such other person at such other place as the Company shall designate to
the Purchaser in writing; and

               (b) if to the Purchaser, at its address as set forth on the
signature page to this Agreement, or at such other address or addresses as may
have been furnished to the Company in writing.

        Such notice shall be deemed effectively given upon confirmation of
receipt of confirmation by facsimile, one business day after deposit with such
overnight courier or three days after deposit of such registered or certified
airmail with the U.S. Postal Service, as applicable.

10.     MODIFICATION; AMENDMENT

        This Agreement may not be modified or amended except pursuant to an
instrument in writing signed by the Company and the Purchaser.

11.     TERMINATION

        This Agreement may be terminated as to the Purchaser, at the option of
the Purchaser, if the Closing has not occurred on or before thirty (30) days
from the date of this Agreement.

12.     EXPENSES

        Each party to this Agreement shall pay its own fees and expenses
incident to the negotiation, preparation and execution of this Agreement and
related documents (including legal and accounting fees and expenses).

13.     HEADINGS

        The headings of the various sections of this Agreement have been
inserted for convenience of reference only and shall not be deemed to be part of
this Agreement.

                                       19
<PAGE>   45

14.     SEVERABILITY

        If any provision contained in this Agreement should be held to be
invalid, illegal or unenforceable in any respect, the validity, legality and
enforceability of the remaining provisions contained in this Agreement shall not
in any way be affected or impaired thereby.

15.     GOVERNING LAW

        This Agreement shall be governed by and construed in accordance with the
laws of the state of Washington and the federal law of the United States of
America.

16.     COUNTERPARTS

        This Agreement may be executed in two or more counterparts, each of
which shall constitute an original, but all of which, when taken together, shall
constitute but one instrument, and shall become effective when one or more
counterparts have been signed by each party to this Agreement and delivered to
the other parties.

                            [Signature page follows]

                                       20
<PAGE>   46

        IN WITNESS WHEREOF, the parties to this Agreement have caused this
Agreement to be executed by their duly authorized representatives as of the day
and year first above written.

                                        NEORX CORPORATION

                                        By
                                           -------------------------------------
                                        Name:
                                              ----------------------------------
                                        Its:
                                             -----------------------------------

                                        PURCHASER:

                                        ----------------------------------------

                                        By
                                           -------------------------------------
                                        Its:
                                             -----------------------------------
                                        Address:
                                                --------------------------------

                                        ----------------------------------------

                                        ----------------------------------------

                                       21
<PAGE>   47

                                    EXHIBIT A

                                    PURCHASER

                  PURCHASER                      NUMBER OF SHARES

<PAGE>   48

                                   APPENDIX I

                                NEORX CORPORATION

                         STOCK CERTIFICATE QUESTIONNAIRE

        Pursuant to Section 3 of the Agreement, please provide us with the
following information:

1.      The exact name that your Shares are to be registered in (this is the
        name that will appear on your stock certificate(s)). You may use a
        nominee name if appropriate: __________________________________

2.      The relationship between the Purchaser of the Shares and the Registered
        Holder listed in response to item 1 above:
        __________________________________

3.      The mailing address of the Registered Holder listed in response to item
        1 above:

        ___________________________________

        ___________________________________

        ___________________________________

        ___________________________________

4.      The Social Security Number or Tax Identification Number of the
        Registered Holder listed in response to item 1 above:
        ___________________________________

<PAGE>   49

                                   APPENDIX II

                                NEORX CORPORATION

                      REGISTRATION STATEMENT QUESTIONNAIRE

        In connection with the preparation of the Registration Statement, please
provide us with the following information:

1.      Pursuant to the "Selling Shareholder" section of the Registration
        Statement, please state your or your organization's name exactly as it
        should appear in the Registration Statement:
        _____________________________________________

2.      Please provide the number of shares that you or your organization will
        own immediately after Closing, including those Shares purchased by you
        or your organization pursuant to this Purchase Agreement and those
        shares purchased by you or your organization through other transactions:
        _____________________________________________

3.      Have you or your organization had any position, office or other material
        relationship within the last three years with the Company or its
        affiliates? [ ] Yes [ ] No

        If yes, please indicate the nature of any such relationships below:

        _________________________________________________________

        _________________________________________________________

        _________________________________________________________

        _________________________________________________________

<PAGE>   50

                                  APPENDIX III

                   PURCHASER'S CERTIFICATE OF SUBSEQUENT SALE

The undersigned, [an officer of, or other person duly authorized by]
________________________________________________________________________________
              [fill in official name of individual or institution]

hereby certifies that he/she/it is the Purchaser of the shares evidenced by the
attached certificate, and as such, sold such shares on [date] in accordance with
Registration Statement number ________________, and complied with the
requirement of delivering a current prospectus in connection with such sale.

Print or Type:

Name of Purchaser (Individual or Institution):
___________________________________________________________

Name of Individual representing Purchaser (if an Institution)
___________________________________________________________

Title of Individual representing Purchaser (if an Institution):
___________________________________________________________

Signature:

Individual Purchaser or Individual representing Purchaser:

___________________________________________________________

                                      -2-

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00008-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00008-of-00352.parquet"}]]