Document:

Exh 10.1 Officer Letter Amendment - 01

Exhibit 10.1

August 12, 2011

Lexicon Pharmaceuticals, Inc.
8800 Technology Forest Place
The Woodlands, TX 77381
Attention:  General Counsel

Re:     Invus Investment

Ladies and Gentlemen:

Reference is made to (a) the Lexicon Pharmaceuticals, Inc. (the “Company”) Equity Incentive Plan (as amended, supplemented or otherwise modified from time to time, the “Plan”), and (b) all stock option and restricted stock unit agreements between the Company and the undersigned (collectively, the “Equity Incentive Agreements”) pursuant to which the undersigned was granted options or restricted stock units under the Plan to purchase or receive shares of common stock, par value $0.001 per share, of the Company ( “Company Common Stock”).

The undersigned hereby acknowledges and agrees that, notwithstanding any provision to the contrary in any Equity Incentive Agreements or the Plan, neither the execution by the Company of (i) the stock purchase agreement (as amended, supplemented or otherwise modified from time to time, the “Purchase Agreement”), dated June 15, 2007, between the Company and Invus, L.P. (collectively with its affiliates, the “Investor”) or (ii) the stockholders' agreement (as amended, supplemented or otherwise modified from time to time, the “Stockholders' Agreement”), dated June 15, 2007, between the Company and Invus, L.P., nor the consummation of the transactions contemplated by the Purchase Agreement or the Stockholders' Agreement, including, without limitation, the acquisition by the Investor of the Initial Shares and the Rights Shares (as such terms are defined in the Purchase Agreement), the election of any representatives of the Investor to the board of directors of the Company, or the acquisition by the Investor of additional shares of Company Common Stock as permitted or contemplated under the Stockholders' Agreement, will constitute a “Change in Control” as such term is defined in, or result in vesting of any option or restricted stock unit under, any Equity Incentive Agreement or the Plan.  In addition, the undersigned hereby acknowledges and agrees that (A) any applicable Equity Incentive Agreement is hereby deemed modified to effect the foregoing and (B) the undersigned waives any and all rights he or she may have to any accelerated vesting under the terms of the Equity Incentive Agreements or the Plan as a result of the execution of or consummation of the transactions contemplated by the Purchase Agreement and/or the Stockholders' Agreement.

Sincerely,

                                
«FullName»

    
Accepted and agreed by 
Lexicon Pharmaceuticals, Inc.

By:                                             
Name:                                     
Title:Exh 4.8 Form of Subscription Rights Certificate and Election Form

Exhibit 4.8

LEXICON PHARMACEUTICALS, INC. NON-TRANSFERABLE  SUBSCRIPTION RIGHTS CERTIFICATE AND ELECTION FORM
Investor ID Number
Lexicon Pharmaceuticals, Inc. (the “Company”) is offering (the “Rights Offering”) to its stockholders of record as of the close of business on            , 2011 (the “Record Date”) non-transferable rights (each a “Subscription Right”) to subscribe to purchase up to an aggregate [       ] shares of the Company's common stock, par value $0.001 per share (the “Common Stock”), at a subscription price of $[  ] per share (the “Subscription Price”). Each stockholder of record as of the Record Date will receive, at no charge, one Subscription Right for each share of Common Stock held of record on the Record Date. Each Subscription Right will allow the holder thereof to subscribe to purchase [      ] share(s) of Common Stock at the Subscription Price. Subscription Rights may only be exercised in whole numbers; the Company will not issue fractional shares of Common Stock and will round all shares of Common Stock down to the nearest whole number. All exercises of Subscription Rights are irrevocable.  
For a more complete description of the terms and conditions of the Rights Offering, please refer to the Prospectus dated               , 2011 (the “Prospectus”), which is incorporated herein by reference. Copies of the Prospectus are available upon request from BNY Mellon Shareowner Services from within the U.S., Canada or Puerto Rico toll free at (800) 777-3674, or if you are located outside of the U.S., at (201) 680-6579.
	
																		
	 
	 
	 
	 
	 

	 
	 
	 
	 
	PLEASE CERTIFY YOUR TAXPAYER IDENTIFICATION NUMBER (TIN) BY COMPLETING THE INFORMATION IN BOX NUMBER 5  ON THE REVERSE SIDE.

	 
	 
	 
	 
	 

	 
	 
	 
	 
	SEE INSTRUCTIONS ON THE REVERSE SIDE

	 
	 
	 
	 
	2 o BASIC SHARES TO SUBSCRIBE
	 
	 
	 
	 
	 
	 
	 
	 

	 
	 
	 
	 
	 
	 
	 
	 
	WHOLE SHARES
	 
	 

	 
	 
	 
	 
	 
	 
	 
	 
	 
	 
	 
	 
	 

	1 Signature: This form must be signed by the registered holder(s) exactly as their name(s) appears on the certificate(s) or by person(s) authorized to sign on behalf of the registered holder(s) by documents transmitted herewith.
	 
	3 o OVER-SUBSCRIPTION FOR SHARES
	 
	 
	 
	 
	 
	 
	 
	 

	 
	 
	WHOLE SHARES
	 
	 

	 
	 
	 
	 
	 
	 
	 
	 
	 

	X
	 
	 
	 
	 
	 
	 
	 
	 

	Signature of Shareholder
	Date
	Daytime Telephone #
	 
	ENCLOSED IS MY CHECK FOR
	$
	 
	 

	 
	 
	 
	 
	 
	 
	 
	 
	 

	X
	 
	 
	 
	 
	 
	 
	 
	 

	Signature of Shareholder
	Date
	Daytime Telephone #
	 
	 
	 
	 
	 
	 

	
			
	 
	 
	 

	4
	 
	 

	 
	 
	 

	SUBSCRIPTION CERTIFICATE  NUMBER
	 
	CUSIP NUMBER

	 
	 
	 

	BASIC SHARES TO SUBSCRIBE
	RIGHTS
	RECORD DATE SHARES

	LEXICON PHARMACEUTICALS, INC.
SUBSCRIPTION FOR RIGHTS OFFERING

	                      , 2011

	 A. Number of shares of Common Stock subscribed for through the basic subscription privilege (not to exceed [       ] share(s) for each Right held): _____________________ Shares of Common Stock

	B. Number of shares of Common Stock subscribed for through the over-subscription privilege (No limit, except basic subscription must be fully exercised): _______________________ Shares of Common Stock

	C. Total Subscription Price (sum lines A and B multiplied by $[     ]): $ ____________________

	D. Method of Payment, check (1) or (2):

	 o (1) Certified or Cashier's check or money order payable to BNY Mellon Investor Services (acting on behalf of The Bank of New York Mellon, N.A.,  the Subscription Agent) or

	 o (2) Personal check payable to BNY Mellon Shareowner Services, received no later than ____, 2011.  If your funds do not clear your bank before 5:00 p.m., New York City time, _____, 2011, your request for shares of Common Stock will not be accepted.

	HOW TO CONTACT BNY MELLON SHAREOWNER SERVICES

	By Telephone - 9 a.m. to 6 p.m. New York Time, Monday through Friday, except for bank holidays:

	From within the U.S., Canada or Puerto Rico
1-800-777-3674 (Toll Free)
From outside the U.S.
1-201-680-6579 (Collect)

	SUBSCRIPTION TO PURCHASE SHARES OF COMMON STOCK OF LEXICON PHARMACEUTICALS, INC.
RETURN TO: THE BANK OF NEW YORK MELLON, N.A. C/O BNY MELLON SHAREOWNER SERVICES

	WHERE TO FORWARD YOUR TRANSMITTAL MATERIALS

	By Mail
BNY Mellon Shareowner Services
Attn: Corporate Action Dept.
P.O. Box 3301
South Hackensack, NJ  07606

	 
	By Overnight Courier or By Hand
BNY Mellon Shareowner Services
Attn: Corporate Action Dept., 27th Floor
480 Washington Boulevard
Jersey City, NJ  07310

	THIS RIGHTS OFFERING EXPIRES AT 5:00 P.M., NEW YORK CITY TIME, ON ______, 2011 AND THIS SUBSCRIPTION CERTIFICATE IS VOID THEREAFTER.

	 
	 
	 

	
			
	SUBSTITUTE FORM W-9 - Department of the Treasury,
Internal Revenue Service
Payer's Request for Taxpayer Identification Number (TIN)

	 

	Part 1 PLEASE PROVIDE YOUR TAXPAYER IDENTIFICATION NUMBER (TIN) IN THE BOX AT THE RIGHT AND CERTIFY BY SIGNING AND DATING BELOW
	FILL IN the space below

	 

	Under penalties of perjury, I certify that:
1.The number shown on this form is my correct taxpayer identification number (or I am waiting for a number to be issued to me), and
2.I am not subject to backup withholding because: (a) I am exempt from backup withholding, or (b) I have not been notified by the Internal Revenue Service (IRS) that I am subject to backup withholding as a result of a failure to report all interest or dividends, or (c) the IRS has notified me that I am no longer subject to backup withholding, and
3.I am a U.S. citizen or other U.S. person (including a U.S. resident alien).
	EXEMPT PAYEE o

	Please check appropriate box:
Individual/Sole proprietor  o
C Corporation  o S Corporation  o Partnership  o Trust/estate  o

	o Limited liability company. Enter the tax classification (C=C Corporation, S=S Corporation, P=Partnership
                                          
       ————————————————— Enter appropriate tax classification here

	  o  Other                            

	See enclosed Instructions

	Certification instructions.  You must cross out item 2 above if you have been notified by the IRS that you are currently subject to backup withholding because you have failed to report all interest and dividends on your tax return.  For real estate transactions, item 2 does not apply.  For mortgage interest paid, acquisition or abandonment of secured property cancellation of debt, contributions to an individual retirement arrangement (IRA), and generally, payments other than interest and dividends, you are not required to sign the certification, but you must provide your correct TIN.

	Signature
	Date:

COMPLETE ALL APPLICABLE SECTIONS OF THIS FORM USING THE INSTRUCTIONS BELOW.
		
	1.
	Sign and date Box 1 and include your day time phone number.

		
	2.
	Place an X in the box and fill in the number of whole shares you wish to subscribe for under your basic subscription privileges.

		
	3.
	Place an X the box and fill in the number of whole shares you wish to over-subscribe for your over-subscription privileges.  (No limit, except basic subscription must be fully exercised).

		
	4.
	Rights card and calculation section for determining your basic/over-subscription privileges.

		
	5.
	PLEASE SIGN IN BOX 5 TO CERTIFY YOUR TAXPAYER ID OR SOCIAL SECURITY NUMBER if you are a U.S. Taxpayer.  If the Taxpayer ID or Social Security Number is incorrect or blank, write the corrected number in Box 5 and sign to certify.  Please note that BNY Mellon Shareowner Services may withhold 28% of your proceeds as required by the IRS if the Taxpayer ID or Social Security Number is not certified on our records. To avoid back up withholding, you are required to fully and accurately complete the Substitute Form W-9.  For additional instructions, please see the "Important Tax Information" document.  Note: You are required to check the appropriate box for your status (Individual/Sole proprietor, Corporation, etc.) to avoid withholding. If you are a non - U.S. Taxpayer, please complete and return form W-8BEN.

THIS RIGHTS OFFERING HAS BEEN QUALIFIED OR IS BELIEVED TO BE EXEMPT FROM QUALIFICATION ONLY UNDER THE FEDERAL LAWS OF THE UNITED STATES AND THE LAWS OF THE STATES IN THE UNITED STATES. RESIDENTS OF OTHER JURISDICTIONS MAY NOT PURCHASE THE SECURITIES OFFERED HEREBY UNLESS THEY CERTIFY THAT THEIR PURCHASES OF SUCH SECURITIES ARE EFFECTED IN ACCORDANCE WITH THE APPLICABLE LAWS OF SUCH JURISDICTIONS.
THIS RIGHTS OFFERING EXPIRES AT 5:00 P.M., NEW YORK CITY TIME, ON _______, 2011 AND THIS SUBSCRIPTION CERTIFICATE AND ELECTION FORM IS VOID THEREAFTER. BY EXECUTING THIS SUBSCRIPTION RIGHTS CERTIFICATE AND ELECTION FORM ON THE REVERSE SIDE, THE UNDERSIGNED HEREBY ACKNOWLEDGES AND AGREES TO THE FOLLOWING TERMS AND CONDITIONS: (1) AT THE TIME OF SUBMITTING THIS SUBSCRIPTION RIGHTS CERTIFICATE AND ELECTION FORM, THE UNDERSIGNED AGREES TO DELIVER THE FULL PURCHASE PRICE FOR ALL SHARES OF COMMON STOCK AND (2) THE UNDERSIGNED AGREES TO ALL OF THE TERMS AND CONDITIONS OF THE RIGHTS OFFERING AS SET FORTH IN THE PROSPECTUS, WHICH ARE INCORPORATED HEREIN BY REFERENCE, AND OF THIS SUBSCRIPTION RIGHTS CERTIFICATE AND ELECTION FORM.

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00193-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00193-of-00352.parquet"}]]