Document:

Indenture

 Exhibit 4.1 

 
  

 
 AFFYMETRIX, INC.,
Issuer 
 and 
 THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A., Trustee 

INDENTURE 

Dated as of June 25, 2012 
  

 
 SENIOR DEBT
SECURITIES 
  
  

 

 TABLE OF CONTENTS 

 

					
	 	  	Page	 
	
	ARTICLE 1	  
	DEFINITIONS	  
		
	 Section 1.01. Certain Terms Defined; Rules of Construction
	  	 	1	  
	
	ARTICLE 2	  
	SECURITIES	  
		
	 Section 2.01. Forms Generally
	  	 	6	  
	 Section 2.02. Form of Trustee’s Certification of Authentication
	  	 	7	  
	 Section 2.03. Amount Unlimited; Issuable in Series
	  	 	7	  
	 Section 2.04. Authentication and Delivery of Securities
	  	 	10	  
	 Section 2.05. Execution of Securities
	  	 	11	  
	 Section 2.06. Certificate of Authentication
	  	 	11	  
	 Section 2.07. Denomination and Date of Securities; Payments of Interest
	  	 	11	  
	 Section 2.08. Registration, Transfer and Exchange
	  	 	12	  
	 Section 2.09. Mutilated, Defaced, Destroyed, Lost and Stolen Securities
	  	 	14	  
	 Section 2.10. Cancellation of Securities; Destruction Thereof
	  	 	15	  
	 Section 2.11. Temporary Securities
	  	 	15	  
	 Section 2.12. Authenticating Agent
	  	 	16	  
	 Section 2.13. Global Securities
	  	 	16	  
	 Section 2.14. CUSIP Numbers
	  	 	18	  
	
	ARTICLE 3	  
	COVENANTS OF THE ISSUER	  
		
	 Section 3.01. Payment of Principal and Interest
	  	 	19	  
	 Section 3.02. Offices for Payments, etc
	  	 	19	  
	 Section 3.03. Paying Agents
	  	 	20	  
	 Section 3.04. Certificate of the Issuer
	  	 	21	  
	 Section 3.05. Reports by the Issuer
	  	 	21	  
	 Section 3.06. Existence
	  	 	21	  
	
	ARTICLE 4	  
	REMEDIES OF THE TRUSTEE AND HOLDERS ON
EVENT OF DEFAULT	  
		
	 Section 4.01. Event of Default; Acceleration of Maturity; Waiver of Default.
	  	 	22	  
	 Section 4.02. Collection of Indebtedness by Trustee; Trustee May Prove Debt
	  	 	24	  
	 Section 4.03. Application of Proceeds
	  	 	26	  
	 Section 4.04. Suits for Enforcement
	  	 	27	  
	 Section 4.05. Restoration of Rights on Abandonment of Proceedings
	  	 	27	  
	 Section 4.06. Limitations on Suits by Holder
	  	 	27	  

					
	 	  	Page	 
	 Section 4.07. Unconditional Right of Holders to Institute Certain Suits
	  	 	28	  
	 Section 4.08. Powers and Remedies Cumulative; Delay or Omission Not Waiver of Default
	  	 	28	  
	 Section 4.09. Control by Holders
	  	 	28	  
	 Section 4.10. Waiver of Past Defaults
	  	 	29	  
	 Section 4.11. Trustee to Give Notice of Default, But May Withhold in Certain Circumstances
	  	 	29	  
	 Section 4.12. Right of Court to Require Filing of Undertaking to Pay Costs
	  	 	29	  
	
	ARTICLE 5	  
	CONCERNING THE TRUSTEE	  
		
	 Section 5.01. Duties and Responsibilities of the Trustee; During Default; Prior to Default.
	  	 	30	  
	 Section 5.02. Trustee’s Obligations with Respect to the Covenants
	  	 	30	  
	 Section 5.03. Property Held by Trustee
	  	 	31	  
	 Section 5.04. Reports by the Trustee to Holders
	  	 	31	  
	 Section 5.05. Certain Rights of the Trustee
	  	 	31	  
	 Section 5.06. Trustee and Agents May Hold Securities; Collections, etc
	  	 	33	  
	 Section 5.07. Compensation and Indemnification of Trustee and Its Prior Claim
	  	 	33	  
	 Section 5.08. Right of Trustee to Rely on Officer’s Certificate, etc
	  	 	34	  
	 Section 5.09. Disqualification; Conflicting Interests
	  	 	34	  
	 Section 5.10. Persons Eligible for Appointment as Trustee
	  	 	34	  
	 Section 5.11. Resignation and Removal; Appointment of Successor Trustee
	  	 	34	  
	 Section 5.12. Acceptance of Appointment by Successor
	  	 	36	  
	 Section 5.13. Merger, Conversion, Consolidation or Succession to Business of Trustee
	  	 	37	  
	 Section 5.14. Preferential Collection of Claims Against the Issuer
	  	 	37	  
	 Section 5.15. Trustee’s Disclaimer
	  	 	37	  
	
	ARTICLE 6	  
	CONCERNING THE HOLDERS	  
		
	 Section 6.01. Evidence of Action Taken by Holders
	  	 	38	  
	 Section 6.02. Proof of Execution of Instruments and of Holding of Securities; Record Date
	  	 	38	  
	 Section 6.03. Holders to Be Treated as Owners
	  	 	39	  
	 Section 6.04. Securities Owned by Issuer Deemed Not Outstanding
	  	 	39	  
	 Section 6.05. Right of Revocation of Action Taken
	  	 	40	  
	
	ARTICLE 7	  
	AMENDMENTS, SUPPLEMENTS AND WAIVERS	  
		
	 Section 7.01. Supplemental Indentures without Consent of Holders
	  	 	40	  
	 Section 7.02. Supplemental Indentures with Consent of Holders
	  	 	41	  

  
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	 	  	Page	 
	 Section 7.03. Execution of Amendments or Supplemental Indentures or Waivers
	  	 	42	  
	 Section 7.04. Effect of Amendment, Supplemental Indenture or Waiver
	  	 	43	  
	 Section 7.05. Effect of Consent
	  	 	43	  
	 Section 7.06. Notation on Securities in Respect of Amendments, Supplemental Indentures or Waivers
	  	 	43	  
	 Section 7.07. Conformity with the Trust Indenture Act
	  	 	44	  
	
	ARTICLE 8	  
	CONSOLIDATION, MERGER, SALE OR CONVEYANCE	  
		
	 Section 8.01. Consolidation, Merger or Sale of Assets by the Issuer
	  	 	44	  
	 Section 8.02. Successor Substituted
	  	 	44	  
	
	ARTICLE 9	  
	SATISFACTION AND DISCHARGE; UNCLAIMED AMOUNTS	  
		
	 Section 9.01. Satisfaction and Discharge of Indenture
	  	 	45	  
	 Section 9.02. Application by Trustee of Funds Deposited for Payment of Securities
	  	 	46	  
	 Section 9.03. Repayment of Property Held by Paying Agent
	  	 	46	  
	 Section 9.04. Return of Property Held by Trustee and Paying Agent Unclaimed for Two Years
	  	 	46	  
	
	ARTICLE 10	  
	MISCELLANEOUS PROVISIONS	  
		
	 Section 10.01. Incorporators, Stockholders, Employees, Officers and Directors of Issuer Exempt from Individual
Liability
	  	 	47	  
	 Section 10.02. Provisions of Indenture for the Sole Benefit of Parties and Holders
	  	 	47	  
	 Section 10.03. Successors and Assigns of Issuer Bound by Indenture
	  	 	47	  
	 Section 10.04. Notices and Demands on Issuer, Trustee and Holders
	  	 	47	  
	 Section 10.05. Officer’s Certificates and Opinions of Counsel; Statements to Be Contained
Therein
	  	 	48	  
	 Section 10.06. Payments Due on Saturdays, Sundays and Holidays
	  	 	49	  
	 Section 10.07. Trust Indenture Act of 1939
	  	 	49	  
	 Section 10.08. New York Law to Govern
	  	 	50	  
	 Section 10.09. Jurisdiction; Waiver Of Jury Trial
	  	 	50	  
	 Section 10.10. Counterparts
	  	 	50	  
	 Section 10.11. Effect of Headings
	  	 	50	  
	 Section 10.12. Separability
	  	 	50	  

  
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	 	  	Page	 
	
	ARTICLE 11	  
	REDEMPTION OF SECURITIES AND SINKING FUND
PROVISIONS	  
		
	 Section 11.01. Applicability of Article
	  	 	50	  
	 Section 11.02. Notice of Redemption; Partial Redemptions
	  	 	50	  
	 Section 11.03. Payment of Securities Called for Redemption
	  	 	52	  
	 Section 11.04. Exclusion of Certain Securities from Eligibility for Selection for Redemption
	  	 	53	  
	 Section 11.05. Mandatory and Optional Sinking Funds
	  	 	53	  

  
 iv 

 INDENTURE, dated as of June 25, 2012 between AFFYMETRIX, INC. (the
“Issuer”) and THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A. (the “Trustee”), 

W I T N E S S E T H: 

WHEREAS, for its lawful corporate purposes, the Issuer has duly authorized the execution and delivery of the Indenture to provide for the
issuance of unsecured debt securities in one or more series (the “Securities”) up to such principal amount or amounts as may from time to time be authorized in accordance with the terms of the Indenture and to provide, among other
things, for the authentication, delivery and administration thereof; 
 WHEREAS, all things necessary to make the Indenture a
valid indenture and agreement according to its terms have been done; 
 WHEREAS, the Indenture is subject to, and will be
governed by, the provisions of the Trust Indenture Act of 1939 (the “Trust Indenture Act”) that are required to be a part of and govern indentures qualified under the Trust Indenture Act; and 

NOW, THEREFORE, in consideration of the premises and the purchases of the Securities by the holders thereof, the Issuer and the Trustee
mutually covenant and agree for the equal and proportionate benefit of the respective holders from time to time of the Securities as follows: 
 ARTICLE 1 
 DEFINITIONS 

Section 1.01. Certain Terms Defined; Rules of Construction. The following terms (except as otherwise expressly provided or
unless the context otherwise clearly requires) for all purposes of the Indenture and of any indenture supplemental hereto shall have the respective meanings specified in this Section. All other terms used in the Indenture that are defined in the
Trust Indenture Act, or the definitions of which are referred to in the Trust Indenture Act, including terms defined therein by reference to the Securities Act (except as herein otherwise expressly provided or unless the context otherwise clearly
requires), shall have the meanings assigned to such terms in the Trust Indenture Act and in the Securities Act as in force at the date of the Indenture. All accounting terms used herein and not expressly defined shall have the meanings assigned to
such terms in accordance with generally accepted accounting principles, and the term “generally accepted accounting principles” means such accounting principles as are generally accepted at the time of any computation. The words
“herein”, “hereof” and “hereunder” and other words of similar import refer to the Indenture as a whole and not to any particular Article, Section or other subdivision. The terms defined in this
Article have the meanings assigned to them in this Article and include the plural as well as the singular. Except as otherwise expressly provided or unless the context otherwise clearly requires, references to agreements or instruments, or to
statutes or regulations, are to such 

 
agreements or instruments, or statutes or regulations, as amended from time to time (or to successor statutes and regulations). 

“Agent Member” means a member of, or a participant in, the Depositary. 

“Authenticating Agent” means an authenticating agent with respect to any of the series of Securities appointed with
respect to all or any series of the Securities by the Trustee pursuant to Section 2.12. 
 “Bankruptcy
Law” means Title 11 of the United States Code or any similar Federal or State law for the relief of debtors. 

“Board of Directors” means either the Board of Directors of the Issuer or any committee of such Board duly authorized by
such Board to act hereunder. 
 “Business Day” means, with respect to any Security, any day other than a
Saturday, a Sunday or a day on which the Federal Reserve Bank of New York is authorized or required by law or executive order to close or be closed. 
 “Commission” means the United States Securities and Exchange Commission, as from time to time constituted, created under the Exchange Act, or if at any time after the execution and
delivery of the Indenture such Commission is not existing and performing the duties now assigned to it under the Trust Indenture Act, then the body performing such duties on such date. 

“company” means a corporation or a limited liability company. 

“conversion agent” has the meaning assigned to such term in Section 3.02. 

“Corporate Trust Office” means the principal office of the Trustee at which at any time its corporate trust business
shall be administered, which office at the date hereof is located at 400 South Hope Street, Suite 400, Los Angeles, CA 90071, Attention: Corporate Trust Unit, or such other address as the Trustee may designate from time to time by notice to the
Holders and the Company, or the principal corporate trust office of any successor Trustee (or such other address as such successor Trustee may designate from time to time by notice to the Holders and the Company). 

“Depositary” means, with respect to Securities of any series, for which the Issuer shall determine that such Securities
will be issued as a Global Security, the Depository Trust Company, New York, New York, another clearing agency, or any successor registered as a clearing agency under the Exchange Act, or other applicable statute or regulation, which, in each case,
shall be designated by the Issuer pursuant to either Section 2.01 or 2.13. 
 “Event of Default” has the
meaning assigned to such term in Section 4.01. 

  
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 “Exchange Act” means the Securities Exchange Act of 1934 and any statute
successor thereto, in each case as amended from time to time, and the rules and regulations of the Commission promulgated thereunder. 
 “Global Security” means, with respect to any series of Securities, a Security executed by the Issuer and delivered by the Trustee to the Depositary or pursuant to a safekeeping agreement
with the Depositary, all in accordance with the Indenture, which shall be registered in global form without interest coupons in the name of the Depositary or its nominee. 
 “Governmental Obligations” means securities that are (i) direct obligations of the United States of America for the payment of which its full faith and credit is pledged or
(ii) obligations of a Person controlled or supervised by and acting as an agency or instrumentality of the United States of America, the payment of which is unconditionally guaranteed as a full faith and credit obligation by the United States
of America that, in either case, are not callable or redeemable at the option of the issuer thereof, and shall also include a depositary receipt issued by a bank (as defined in Section 3(a)(2) of the Securities Act) as custodian with respect to
any such Governmental Obligation or a specific payment of principal of or interest on any such Governmental Obligation held by such custodian for the account of the holder of such depositary receipt; provided however, that (except as required
by law) such custodian is not authorized to make any deduction from the amount payable to the holder of such depositary receipt from any amount received by the custodian in respect of the Governmental Obligation or the specific payment of principal
of or interest on the Governmental Obligation evidenced by such depositary receipt. 
 “Holder” means the
registered holder of any Security. 
 “Indenture” means this instrument as originally executed and delivered
or, if amended or supplemented as herein provided, as so amended or supplemented or both, and shall include the forms and terms of particular series of Securities established as contemplated hereunder. 

“Interest Payment Date”, when used with respect to any installment of interest on a Security of a particular series,
means the date specified in such Security or in a Resolution of the Board of Directors or in an indenture supplemental hereto with respect to such series as the fixed date on which an installment of interest with respect to Securities of that series
is due and payable. 
 “Issue Date” means the date on which the Securities of a series are originally issued.

 “Issuer” means, unless otherwise explicitly provided herein, the Person named as the “Issuer” in
the first paragraph of this instrument until a successor Person shall have 

  
 3 

 
become such pursuant to the applicable provisions of the Indenture, and thereafter “Issuer” shall mean such successor Person. 

“Issuer Order” has the meaning assigned to such term in Section 2.04. 

“mandatory sinking fund payment” has the meaning assigned to such term in Section 11.05. 

“Notice of Default” has the meaning assigned to such term in Section 4.01(d). 

“Officer’s Certificate” means a certificate signed on behalf of the Issuer by the chairman of the Board of
Directors, chief executive officer, chief financial officer, principal accounting officer, treasurer, president, any vice president, controller, secretary, any assistant secretary or the general counsel of the Issuer. 

“Opinion of Counsel” means an opinion in writing signed by legal counsel who may be an employee of or counsel to the
Issuer. 
 “optional sinking fund payment” has the meaning assigned to such term in Section 11.05.

 “Original Issue Discount Security” means any Security that provides for an amount less than the principal
amount thereof to be due and payable upon a declaration of acceleration of the maturity thereof pursuant to Section 4.01. 

“Outstanding”, when used with reference to Securities, shall, subject to the provisions of Section 6.04, mean, as
of any particular time, all Securities authenticated and delivered by the Trustee under the Indenture, except: 

(a) Securities cancelled by the Trustee or accepted by the Trustee for cancellation; 

(b) Securities, or portions thereof, for the payment or redemption of which sums necessary to pay all amounts then due
shall have been deposited in trust with the Trustee or with any paying agent (other than the Issuer) or shall have been set aside, segregated and held in trust by the Issuer for the Holders of such Securities (if the Issuer shall act as its own
paying agent), provided that if such Securities, or portions thereof, are to be redeemed prior to the maturity thereof, notice of such redemption or repurchase shall have been given as herein provided, or provision satisfactory to the Trustee
shall have been made for giving such notice; 
 (c) Securities in substitution for which other Securities shall
have been authenticated and delivered, or which shall have been paid, pursuant to the terms of Section 2.09 unless and until the Trustee and the Issuer receive proof satisfactory to them that the substituted Security is held by a bona
fide purchaser; 

  
 4 

 (d) in the case of convertible Securities, Securities converted and required
to be or deemed to be cancelled pursuant to the terms of such Securities and the Indenture; and 
 (e)
Securities repurchased by the Issuer pursuant to Section 2.10. 
 In determining whether the Holders of the requisite
principal amount of Outstanding Securities of any or all series have given any request, demand, authorization, direction, notice, consent or waiver hereunder, the principal amount of an Original Issue Discount Security that shall be deemed to be
Outstanding for such purposes shall be the amount of the principal thereof that would be due and payable as of the date of such determination upon a declaration of acceleration of the maturity thereof pursuant to Section 4.01. 

“paying agent” has the meaning assigned to such term in Section 3.02. 

“Person” means any individual, corporation, limited liability company, partnership, joint venture, association, joint
stock company, trust, unincorporated organization, or any other entity, including any government or any agency or political subdivision thereof. 
 “principal” whenever used with reference to the Securities or any Security or any portion thereof, shall be deemed to include “and premium, if any”. 

“Register” has the meaning assigned to it in Section 2.08. 

“Registrar” means a Person engaged to maintain the Register. 

“Resolution of the Board of Directors” means a copy of the resolution certified by the secretary or an assistant
secretary of the Issuer to have been duly adopted by the Board of Directors and to be in full force and effect on the date of such certification. 
 “Responsible Officer” when used with respect to the Trustee means any officer of the Trustee within the Corporate Trust Office of the Trustee with direct responsibility for the
administration of the Indenture and also, with respect to a particular matter, any other officer of the Trustee to whom such matter is referred because of such officer’s knowledge and familiarity with the particular subject. 

“Securities Act” means the Securities Act of 1933 and any statute successor thereto, in each case as amended from time
to time, and the rules and regulations of the Commission promulgated thereunder. 

  
 5 

 “Security” or “Securities” has the meaning stated in the
first recital of the Indenture, or, as the case may be, Securities that have been authenticated and delivered under the Indenture. 
 “sinking fund payment date” has the meaning assigned to such term in Section 11.05. 
 “Surviving Entity” has the meaning assigned to such term in Section 8.01. 
 “Trustee” means the Person identified as “Trustee” in the first paragraph hereof and any successor trustee under the Indenture pursuant to Article 5. 

“Trust Indenture Act” means the Trust Indenture Act of 1939 as in force at the date as of which this instrument was
executed; provided, however, that in the event the Trust Indenture Act of 1939 is amended after such date, “Trust Indenture Act” means, to the extent required by any such amendment, the Trust Indenture Act of 1939 as so amended.

 “vice president” when used with respect to the Issuer, means any vice president, whether or not designated
by a number or a word or words added before or after the title of “vice president”. 
 “Yield to
Maturity” means the yield to maturity on a series of securities, calculated at the time of issuance of such series, or, if applicable, at the most recent redetermination of interest on such series, and calculated in accordance with accepted
financial practice. 
 ARTICLE 2 
 SECURITIES 
 Section 2.01 . Forms Generally. The Securities
of each series shall be substantially in such form (not inconsistent with the Indenture) as shall be established by or pursuant to a Resolution of the Board of Directors and set forth in an Officer’s Certificate, or in one or more indentures
supplemental hereto, in each case with such appropriate insertions, omissions, substitutions and other variations as are required or permitted by the Indenture and may have imprinted or otherwise reproduced thereon such legends, notations or
endorsements as may be required to comply with any law or with any rules or regulations pursuant thereto, or with any rules of any securities exchange or to conform to general usage, all as may be determined by the officer executing such Securities,
as evidenced by such officer’s execution of the Securities. 
 The definitive Securities shall be printed, lithographed or
engraved on steel engraved borders or may be produced in any other manner, all as determined by the officer executing such Securities, as evidenced by such officer’s execution of such Securities. 

  
 6 

 Section 2.02 . Form of Trustee’s Certification of Authentication. The
Trustee’s certificate of authentication on all Securities shall be in substantially the following form: 
 This is one of
the Securities of the series designated herein and referred to in the within-mentioned Indenture. 
  

			
	 The Bank of New York Mellon Trust
       Company, N.A., as Trustee

		
	by:	 	 
		 	Authorized Signatory

 Section 2.03 . Amount Unlimited; Issuable in Series. Subject to compliance with the
representations, warranties and covenants set forth herein, in any Officer’s Certificate, in any indenture supplemental hereto and in any amendment hereto or thereto, the aggregate principal amount of Securities which may be authenticated and
delivered under the Indenture is unlimited. 
 The Securities may be issued in one or more series. There shall be established in
or pursuant to a Resolution of the Board of Directors and set forth in an Officer’s Certificate, or established in one or more indentures supplemental hereto, prior to the issuance of Securities of any series: 

(a) the title of the Securities of the series (which shall distinguish the Securities of the series from all other
Securities); 
 (b) any limit upon the aggregate principal amount of the Securities of the series that may be
authenticated and delivered under the Indenture (except for Securities authenticated and delivered upon registration of transfer of, or in exchange for, or in lieu of, other Securities of the series pursuant to Section 2.08, 2.09, 2.11 or
11.03); 
 (c) the date or dates on which the principal of the Securities of the series is payable; 

(d) the rate or rates at which the Securities of the series shall bear interest, if any, or the method by which such rate
shall be determined, the date or dates from which such interest shall accrue, the Interest Payment Dates on which such interest shall be payable and the record dates for the determination of Holders to whom interest is payable on such Interest
Payment Dates; 

  
 7 

 (e) the right, if any, to extend the interest payment periods and the
duration of such extension; 
 (f) the place or places where the principal of and any interest on Securities of
the series shall be payable (if other than as provided in Section 3.02); 
 (g) the price or prices at
which, the period or periods within which and the terms and conditions upon which Securities of the series may be redeemed, in whole or in part, at the option of the Issuer, pursuant to any sinking fund or otherwise; 

(h) the obligation, if any, of the Issuer to redeem, purchase or repay Securities of the series pursuant to any sinking
fund of otherwise at the option of a Holder thereof and the price or prices at which and the period or periods within which and the terms and conditions upon which Securities of the series shall be redeemed, purchased or repaid, in whole or in part,
pursuant to such obligation; 
 (i) if other than denominations of $2,000 and any multiple of $1,000 in excess
thereof, the denominations in which Securities of the series shall be issuable; 
 (j) the percentage of the
principal amount at which the Securities will be issued, and, if other than the principal amount thereof, the portion of the principal amount of Securities of the series which shall be payable upon declaration of acceleration of the maturity thereof
pursuant to Section 4.01 or provable in bankruptcy pursuant to Section 4.02; 
 (k) whether the
Securities are issuable under Rule 144A or Regulation S and, in such case, any provisions unique to such form of issuance including any transfer restrictions or exchange and registration rights; 

(l) any and all other terms of the series (which terms shall not be inconsistent with the provisions of the Indenture)
including any terms which may be required by or advisable under U.S. law or regulations or advisable in connection with the marketing of Securities in that series; 

(m) whether the Securities are issuable as a Global Security and, in such case, the identity of the Depositary for such
series; 
 (n) any deletion from, modification of or addition to the Events of Default or covenants provided for
with respect to the Securities of the series; 
 (o) any provisions granting special rights to Holders when a
specified event occurs; 

  
 8 

 (p) whether and under what circumstances the Issuer will pay additional
amounts on the Securities of the series held by a Person who is not a U.S. Person in respect of any tax, assessment or governmental charge withheld or deducted and, if so, whether the Issuer will have the option to redeem the Securities of the
series rather than pay such additional amounts; 
 (q) any special tax implications of the Securities, including
provisions of Securities that are issued with original issue discount for U.S. federal income tax purposes; 

(r) any trustees, authenticating or paying agents, transfer agents or registrars or any other agents with respect to the
Securities of such series; 
 (s) any guarantor or co-issuer of the Securities of the series; 

(t) any special interest premium or other premium; 

(u) whether the Securities are convertible or exchangeable into cash, common stock or other equity securities of the
Issuer or a combination thereof and the terms and conditions upon which such conversion or exchange shall be effected; and 
 (v) the currency in which payments shall be made, if other than U.S. dollars. 

All Securities of any one series shall be substantially identical except as to denomination and except as may otherwise be provided in or
pursuant to such Resolution of the Board of Directors and set forth in an Officer’s Certificate, or in any indenture supplemental hereto. All Securities of any one series need not be issued at the same time, and unless otherwise provided, a
series may, without the consent of the Holders, be reopened for issuance of additional Securities of such series; provided that if any such additional Securities are not fungible with the Securities of such series initially issued hereunder for U.S.
federal income tax or securities law purposes, such additional Securities will have one or more separate CUSIP numbers. 
 Any
additional Securities shall be established in or pursuant to a Resolution of the Board of Directors and set forth in an Officer’s Certificate, or established in one or more indentures supplemental hereto, prior to the issuance of Securities of
any series the following information: 
 (i) the aggregate principal amount of such additional Securities to be
authenticated and delivered pursuant to the Indenture; 
 (ii) the issue price, the issue date and the CUSIP
number, if any, of such additional Securities; and 

  
 9 

 (iii) whether such additional Securities shall be transfer restricted
Securities or have any registration or exchange rights. 
 Section 2.04. Authentication and Delivery of Securities. At
any time and from time to time after the execution and delivery of the Indenture, the Issuer may deliver Securities of any series executed by the Issuer to the Trustee for authentication, together with a written order of the Issuer, signed in the
name of the Issuer by any one of the following officers: chairman of the Board of Directors, chief executive officer, chief financial officer, principal accounting officer, treasurer, president, any vice president, secretary, controller or general
counsel of the Issuer (an “Issuer Order”). The Trustee, in accordance with such written order, shall authenticate and deliver such Securities. 
 In authenticating such Securities and accepting the additional responsibilities under the Indenture in relation to such Securities, the Trustee shall be entitled to receive and (subject to
Section 5.01) shall be fully protected in relying upon: 
 (a) a certified copy of any Resolution or
Resolutions of the Board of Directors authorizing the action taken pursuant to the resolution or resolutions delivered under clause 2.04(b) below; 
 (b) a copy of any Resolution or Resolutions of the Board of Directors relating to such series, in each case certified by the secretary or an assistant secretary of the Issuer; 

(c) an executed supplemental indenture, if any; 

(d) in lieu of a supplemental indenture, an Officer’s Certificate setting forth the form and terms of the Securities
as required pursuant to Section 2.01 and 2.03, respectively, and prepared in accordance with Section 10.05; and 
 (e) an Opinion of Counsel, prepared in accordance with Section 10.05, to the effect that 
 (i) the form or forms and terms of such Securities have been established by or pursuant to a Resolution of the Board of Directors and set forth in an Officer’s Certificate, or by a supplemental
indenture as permitted by Section 2.01 and 2.03 in conformity with the provisions of the Indenture; and 

(ii) such Securities, when authenticated and delivered by the Trustee and issued by the Issuer in the manner and subject
to any conditions specified in such Opinion of Counsel, will constitute valid and binding obligations of the Issuer entitled to the benefits of the Indenture, and enforceable against the Issuer in accordance with their terms, except to the extent
that enforcement thereof may be limited by bankruptcy, 

  
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insolvency, reorganization, moratorium, fraudulent conveyance or similar laws now or hereafter in effect relating to creditor’s rights generally, and general principles of equity (regardless
of whether enforceability is considered in a proceeding in equity or at law). 
 The Trustee shall have the right to decline to
authenticate and deliver any Securities under this section if the Trustee, being advised by counsel, determines that such action may not lawfully be taken by the Issuer or if the Trustee in good faith by its board of directors or board of trustees,
executive committee, or a trust committee of directors or trustees or Responsible Officers shall determine that such action would expose the Trustee to personal liability. 
 Section 2.05. Execution of Securities. The Securities shall be signed in the name of the Issuer by any one of its chairman of the Board of Directors, chief executive officer, chief financial
officer, principal accounting officer, treasurer, president, any vice president or general counsel, attested by its secretary, assistant secretary, chief financial officer, treasurer or assistant treasurer. Such signature may be the manual or
facsimile signature of the present or any future such officer. Typographical and other minor errors or defects in any such signature shall not affect the validity or enforceability of any Security that has been duly authenticated and delivered by
the Trustee. 
 In case any officer of the Issuer who shall have signed any of the Securities shall cease to be such officer
before the Security so signed shall be authenticated and delivered by the Trustee or disposed of by the Issuer, such Security nevertheless may be authenticated and delivered or disposed of as though the person who signed such Security had not ceased
to be such officer of the Issuer; and any Security may be signed on behalf of the Issuer by such person as, at the actual date of the execution of such Security, shall be the proper officer of the Issuer, although at the date of the execution and
delivery of the Indenture any such person was not such an officer. 
 Section 2.06. Certificate of Authentication. Only
such Securities as shall bear thereon a certificate of authentication substantially in the form recited herein, executed by the Trustee by the manual signature of one of its authorized officers, shall be entitled to the benefits of the Indenture or
be valid or obligatory for any purpose. Such certificate by the Trustee upon any Security executed by the Issuer shall be conclusive evidence that the Security so authenticated has been duly authenticated and delivered hereunder and that the Holder
is entitled to the benefits of the Indenture. 
 Section 2.07. Denomination and Date of Securities; Payments of Interest.
The Securities shall be issuable as registered securities without coupons and in denominations as shall be specified as contemplated by Section 2.03. In the absence of any such specification with respect to the Securities of any series, the
Securities of such series shall be issuable in denominations of $2,000 and any multiple of $1,000 in excess thereof. The Securities shall be numbered, lettered, or otherwise distinguished in such manner or in accordance with such plan as the officer
of the Issuer executing the same may determine with the approval of the Trustee as evidenced by the execution and authentication thereof. 

  
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 The principal of and the interest on the Securities of any series, shall be payable in the
coin or currency of the United States of America that at the time is legal tender for public and private debt, at the office or agency of the Issuer maintained for that purpose. 

Each Security shall be dated the date of its authentication, shall bear interest, if any, from the date and shall be payable on the
dates, in each case, established as contemplated by Section 2.03. 
 The Person in whose name any Security of any series is
registered at the close of business on any record date applicable to a particular series with respect to any interest payment date for such series shall be entitled to receive the interest, if any, payable on such interest payment date
notwithstanding any transfer or exchange of such Security subsequent to the record date and prior to such interest payment date, except if and to the extent the Issuer shall default in the payment of the interest due on such interest payment date
for such series, in which case such defaulted interest shall be paid to the Persons in whose names Outstanding Securities for such series are registered at the close of business on a subsequent record date (which shall be not less than five Business
Days prior to the date of payment of such defaulted interest) established by notice given by mail by or on behalf of the Issuer to the Holders not less than 15 days preceding such subsequent record date. The term “record date” as
used with respect to any interest payment date (except a date for payment of defaulted interest) shall mean the date specified as such in the terms of the Securities of any particular series, or, if no such date is so specified, if such interest
payment date is the first day of a calendar month, the fifteenth day of the next preceding calendar month or, if such interest payment date is the fifteenth day of a calendar month, the first day of such calendar month, whether or not such record
date is a Business Day. 
 Section 2.08. Registration, Transfer and Exchange. The Issuer may appoint one or more
Registrars. The Issuer initially appoints the Trustee as Registrar. The Issuer will keep or cause to be kept at each office or agency to be maintained for the purpose as provided in Section 3.02 a register or registers (the
“Register”) in which, subject to such reasonable regulations as it may prescribe, it will register, and will register the transfer of, Securities as in this Article provided. The Register shall be in written form in the English
language or in any other form capable of being converted into such form within a reasonable time. At all reasonable times the Register shall be open for inspection by the Trustee. 

Upon due presentation for registration of transfer of any Security of any series at any such office or agency to be maintained for the
purpose as provided in Section 3.02, the Issuer shall execute and the Trustee shall authenticate and deliver in the name of the transferee or transferees a new Security or Securities of the same series in authorized denominations for a like
aggregate principal amount. 

  
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 Any Security or Securities of any series may be exchanged for a Security or Securities of
the same series in other authorized denominations, in an equal aggregate principal amount. Securities of any series to be exchanged shall be surrendered at any office or agency to be maintained by the Issuer for the purpose as provided in
Section 3.02, and the Issuer shall execute and the Trustee shall authenticate and deliver in exchange therefor the Security or Securities of the same series which the Holder making the exchange shall be entitled to receive, bearing numbers not
contemporaneously Outstanding. 
 All Securities presented for registration of transfer, exchange, repurchase redemption,
conversion or payment shall (if so required by the Issuer or the Trustee) be duly endorsed by, or be accompanied by a written instrument or instruments of transfer in form satisfactory to the Issuer and the Trustee duly executed by, the Holder or
his attorney duly authorized in writing, together with signature guarantees for such Holder or attorney. 
 The Issuer or the
Trustee may require payment of a sum sufficient to cover any tax or other governmental charge that may be imposed in connection with any exchange or registration of transfer of Securities. No service charge shall be made for any such transaction.

 Neither the Issuer nor the Trustee shall be required to exchange or register a transfer of (a) any Securities of any
series for a period of 15 days preceding the first mailing of notice of redemption of Securities of such series to be redeemed, (b) any Securities selected, called or being called for redemption except, in the case of any Security where public
notice has been given that such Security is to be redeemed in part, the portion thereof not so to be redeemed, (c) any Securities, or a portion of any Security, surrendered for repurchase or (d) any Securities surrendered for conversion
or, if a portion of any Security is surrendered for conversion, such portion thereof surrendered for conversion. 
 In addition
to the transfer requirements provided in this Section 2.08, any Security or Securities will be subject to such further transfer restrictions as may be contained in an Officer’s Certificate or indenture supplemental hereto applicable to
such series of Securities. 
 All Securities issued upon any transfer or exchange of Securities shall be valid obligations of
the Issuer, evidencing the same debt, and entitled to the same benefits under the Indenture, as the Securities surrendered upon such transfer or exchange. 
 The Trustee shall have no obligation or duty to monitor, determine or inquire as to compliance with any restrictions on transfer imposed under the Indenture or under applicable law with respect to any
transfer of any interest in any Security (including any transfers between or among Agent Members or beneficial owners of interest in any Global Security) other than to require delivery of such certificates and other documentation or evidence as are
expressly required , and to do so if and when expressly required by the terms of, the Indenture, and to examine the same to determine substantial compliance as to form with the express requirements hereof. 

  
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 Neither the Trustee nor any of its agents shall have any responsibility for any actions
taken or not taken by the Depositary. 
 Section 2.09. Mutilated, Defaced, Destroyed, Lost and Stolen Securities. In case
any temporary or definitive Security shall become mutilated, defaced or be destroyed, lost or stolen, the Issuer in its discretion may execute, and upon the receipt of an Issuer Order, the Trustee shall authenticate and deliver, a new Security of
the same series, bearing a number not contemporaneously Outstanding, in exchange and substitution for the mutilated or defaced Security, or in lieu of and substitution for the Security so destroyed, lost or stolen. In every case the applicant for a
substitute Security shall furnish to the Issuer and to the Trustee and any agent of the Issuer or the Trustee such security or indemnity as may be required by them to indemnify and defend and to save each of them harmless and, in every case of
destruction, loss or theft, evidence to their satisfaction of the destruction, loss or theft of such Security and of the ownership thereof. 
 Upon the issuance of any substitute Security, the Issuer or the Trustee may require the payment of a sum sufficient to cover any tax or other governmental charge that may be imposed in relation thereto
and any other expenses (including the fees and expenses of the Trustee) connected therewith. In case any Security which has matured or is about to mature or has been called for redemption or surrendered for conversion or required repurchase in full
shall become mutilated or defaced or be destroyed, lost or stolen, the Issuer may instead of issuing a substitute Security, pay or authorize the payment of, or convert or authorize the conversion of, the same (without surrender thereof except in the
case of a mutilated or defaced Security), if the applicant for such payment shall furnish to the Issuer and to the Trustee and any agent of the Issuer or the Trustee such security or indemnity as any of them may require to save each of them
harmless, and, in every case of destruction, loss or theft, the applicant shall also furnish to the Issuer and the Trustee and any agent of the Issuer or the Trustee evidence to their satisfaction of the destruction, loss or theft of such Security
and of the ownership thereof. 
 Every substitute Security of any series issued pursuant to the provisions of this section by
virtue of the fact that any predecessor Security is destroyed, lost or stolen shall constitute an additional contractual obligation of the Issuer, whether or not the destroyed, lost or stolen Security shall be at any time enforceable by anyone and
shall be entitled to all the benefits of (but shall be subject to all the limitations of rights set forth in) the Indenture equally and proportionately with any and all other Securities of such series duly authenticated and delivered hereunder. All
Securities shall be held and owned upon the express condition that, to the extent permitted by law, the foregoing provisions are exclusive with respect to the replacement or payment of mutilated, defaced or destroyed, lost or stolen Securities and
shall preclude any and all other rights or remedies notwithstanding any law or statute existing or hereafter enacted to the contrary with respect to the replacement or payment of negotiable instruments or other securities without their surrender.

  
 14 

 Section 2.10. Cancellation of Securities; Destruction Thereof. All Securities
surrendered for payment, repurchase, redemption, registration of transfer or exchange or conversion, or for credit against any payment in respect of a sinking or analogous fund, if surrendered to the Issuer or any agent of the Issuer or the Trustee,
shall be delivered to the Trustee for cancellation or, if surrendered to the Trustee, shall be cancelled by it; and no Securities shall be authenticated in exchange thereof or issued in lieu thereof except as expressly permitted by any of the
provisions of the Indenture. On written request of the Issuer at the time of such surrender, the Trustee shall deliver to the Issuer the Securities cancelled by the Trustee. In the absence of such request, the Trustee shall destroy cancelled
Securities held by it and deliver a certificate of destruction to the Issuer. The Issuer may, to the extent permitted by law, and directly or indirectly (regardless of whether such Securities are surrendered to the Issuer), repurchase Securities of
any series in the open market or otherwise, whether by the Issuer or its Subsidiaries or through a private or public tender or exchange offer or through counterparties to private agreements, including by cash-settled swaps or other derivatives. The
Issuer shall cause any Securities so repurchased (other than Securities repurchased pursuant to cash-settled swaps or other derivatives) to be surrendered to the Trustee for cancellation in accordance with this Section 2.10; provided that if
the Issuer shall acquire any of the Securities, such acquisition shall not operate as a redemption or satisfaction of the indebtedness represented by such Securities unless and until the same are delivered to the Trustee for cancellation.

 Section 2.11. Temporary Securities. Pending the preparation of definitive Securities for any series, the Issuer may
execute and the Trustee shall, upon receipt of an Issuer Order, authenticate and deliver temporary Securities for such series (printed, lithographed, typewritten or otherwise reproduced, in each case in form satisfactory to the Trustee). Temporary
Securities of any series shall be issuable as registered Securities without coupons, of any authorized denomination, and substantially in the form of the definitive Securities of such series but with such omissions, insertions and variations as may
be appropriate for temporary Securities, all as may be determined by the Issuer with the concurrence of the Trustee. Temporary Securities may contain such reference to any provisions of the Indenture as may be appropriate. Every temporary Security
shall be executed by the Issuer and be authenticated by the Trustee upon the same conditions and in substantially the same manner, and with like effect, as the definitive Securities. Without unreasonable delay the Issuer shall execute and shall
furnish definitive Securities of such series and thereupon temporary Securities of such series may be surrendered in exchange therefor without charge at each office or agency to be maintained by the Issuer for that purpose pursuant to
Section 3.02, and the Trustee shall, upon receipt of an Issuer Order, authenticate and deliver in exchange for such temporary Securities of such series a like aggregate principal amount of definitive Securities of the same series of authorized
denominations. Until so exchanged, the temporary Securities of any series shall be entitled to the same benefits under the Indenture as definitive Securities of such series. 

  
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 Section 2.12. Authenticating Agent. So long as any of the Securities of any series
remain Outstanding there may be an Authenticating Agent for any or all such series of Securities which the Trustee shall have the right to appoint. Said Authenticating Agent shall be authorized to act on behalf of the Trustee to authenticate
Securities of such series issued upon exchange, transfer or partial redemption thereof, and Securities so authenticated shall be entitled to the benefits of the Indenture and shall be valid and binding for all purposes as if authenticated by the
Trustee hereunder. All references in the Indenture to the authentication of Securities by the Trustee shall be deemed to include authentication by an Authenticating Agent for such series. Each Authenticating Agent shall be acceptable to the Issuer
and shall be a corporation that has a combined capital and surplus, as most recently reported or determined by it, sufficient under the laws of any jurisdiction under which it is organized or in which it is doing business to conduct a trust
business, and that is otherwise authorized under such laws to conduct such business and is subject to supervision or examination by Federal or State authorities. If at any time any Authenticating Agent shall cease to be eligible in accordance with
these provisions, it shall resign immediately. Any Authenticating Agent may at any time resign by giving written notice of resignation to the Trustee and to the Issuer. The Trustee may at any time (and upon written request by the Issuer shall)
terminate the agency of any Authenticating Agent by giving written notice of termination to such Authenticating Agent and to the Issuer. Upon resignation, termination or cessation of eligibility of any Authenticating Agent, the Trustee may appoint
an eligible successor Authenticating Agent acceptable to the Issuer. Any successor Authenticating Agent, upon acceptance of its appointment hereunder, shall become vested with all the rights, powers and duties of its predecessor hereunder as if
originally named as an Authenticating Agent pursuant hereto. 
 Section 2.13. Global Securities. If the Issuer shall
establish pursuant to Section 2.01 that some or all of the Securities of a particular series are to be issued as a Global Security, then the Issuer shall execute and the Trustee shall, in accordance with Section 2.04, authenticate and
deliver, a Global Security that shall (i) represent, and be issued in a denomination or aggregate denominations equal to the aggregate principal amount of all the Securities to be represented by a Global Security, (ii) be registered in the
name of the Depositary or its nominee, (iii) be delivered to the Trustee as custodian for the Depositary and (iv) bear a legend substantially to the following effect: “Except as otherwise provided in Section 2.13 of the
Indenture, this Security may be transferred, in whole but not in part, only to another nominee of the Depositary or to a successor Depositary or to a nominee of such successor Depositary.” 

Notwithstanding the provisions of Section 2.08, the Global Security of a series may be transferred, in whole but not in part and in
the manner provided in Section 2.08, only to another nominee of the Depositary for such series, or to a successor Depositary for such series selected or approved by the Issuer or to a nominee of such successor Depositary. 

  
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 Ownership of beneficial interests in a registered Global Security will be limited to Agent
Members that have accounts with the Depositary or Persons that may hold interests through Agent Members. Upon the issuance of a registered Global Security, the Depositary will credit, on its book-entry registration and transfer system, the Agent
Members’ accounts with the respective principal or face amounts of the securities beneficially owned by the participants. Any dealers, underwriters or agents participating in the distribution of the Securities will designate the accounts to be
credited. Ownership of beneficial interests in a Global Security will be shown on, and the transfer of ownership interests will be effected only through, records maintained by the Depositary, with respect to interests of Agent Members, and on the
records of Agent Members, with respect to interests of Persons holding through Agent Members. 
 So long as the Depositary, or
its nominee, is the registered owner of a registered Global Security, that Depositary or its nominee, as the case may be, will be considered the sole owner or Holder of the Securities represented by the Global Security for all purposes under the
Indenture. Except as described in this Section 2.13, Agent Members will not be entitled to have the Securities represented by the Global Security registered in their names, will not receive or be entitled to receive physical delivery of the
Securities in definitive form and will not be considered the owners or Holders of the Securities under the Indenture. Accordingly, each Agent Member owning a beneficial interest in a registered Global Security must rely on the procedures of the
Depositary for that registered Global Security and, if a beneficial owner is not an Agent Member, such Person must rely on the procedures of the Agent Member through which the Person owns its interest, to exercise any rights of a Holder under the
Indenture. Notwithstanding the foregoing, the Depositary or its nominee may grant proxies and otherwise authorize any Person (including any Agent Member and any Person that holds a beneficial interest in a Global Security through an Agent Member) to
take any action which a Holder is entitled to take under the Indenture or the Securities, and nothing herein will impair, as between the Depositary and its Agent Members, the operation of customary practices governing the exercise of the rights of a
Holder of any Security. 
 Principal, premium, if any, and interest payments on Securities represented by a Global Security
registered in the name of the Depositary or its nominee will be made to the Depositary or its nominee, as the case may be, as the registered owner of the registered Global Security. None of the Issuer, the Trustee or any other agent of the Issuer,
or any agent of the Trustee will have any responsibility or liability for any aspect of the records relating to payments made on account of beneficial ownership interests in the registered Global Security or for maintaining, supervising or reviewing
any records relating to those beneficial ownership interests. 
 If at any time the Depositary for a series of the Securities
notifies the Issuer that it is unwilling or unable to continue as Depositary for such series or if at any time the 

  
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Depositary for such series shall no longer be registered or in good standing under the Exchange Act, or other applicable statute or regulation, and a successor Depositary for such series is not
appointed by the Issuer within 90 days after the Issuer receives such notice or becomes aware of such condition, as the case may be, this Section 2.13 shall no longer be applicable to the Securities of such series and the Issuer will execute,
and subject to Section 2.08, the Trustee will authenticate and deliver the Securities of such series in definitive registered form without coupons, in authorized denominations, and in an aggregate principal amount equal to the principal amount
of the Global Security of such series in exchange for such Global Security. Upon the exchange of the Global Security for such Securities in definitive registered form without coupons, in authorized denominations, the Global Security shall be
cancelled by the Trustee. 
 In addition, if an Event of Default with respect to the Securities of a series has occurred and is
continuing and a beneficial owner of any such Security requests that its beneficial interest therein be issued as a certificated Security, the Issuer will execute and, subject to Section 2.08, the Trustee will authenticate and deliver
Securities of such series in definitive registered form without coupons, in authorized denominations, and in an aggregate principal amount equal to the principal amount of the Global Security of such series corresponding to such beneficial
owner’s beneficial interest in such Global Security. 
 Securities in definitive registered form issued in exchange for all
or part of the Global Security pursuant to this Section 2.13 shall be registered in such names and in such authorized denominations as the Depositary, pursuant to instructions from its direct or indirect participants or otherwise, shall
instruct the Trustee in writing. The Issuer and the Trustee shall be entitled to conclusively rely on such instructions from the Depositary. The Trustee shall deliver such Securities to the Depositary for delivery to the Persons in whose names such
Securities are so registered. 
 Section 2.14. CUSIP Numbers. The Issuer in issuing the Securities may use
“CUSIP” numbers (if then generally in use), and, if so, the Trustee shall use “CUSIP” numbers in notices of redemption as a convenience to Holders; provided that any such notice may state that no representation is made as to the
correctness of such numbers either as printed on the Securities or as contained in any notice of a redemption and that reliance may be placed only on the other identification numbers printed on the Securities, and any such redemption shall not be
affected by any defect in or omission of such numbers. The Issuer will promptly notify the Trustee in writing of any change in the “CUSIP” numbers. 

  
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 ARTICLE 3 
 COVENANTS OF THE ISSUER 
 Section 3.01. Payment of Principal and Interest. (a) The Issuer covenants and agrees for the benefit of each series of Securities that it will duly and punctually pay or cause to be paid the
principal of, and interest on, each of the Securities of such series at the place or places, at the respective times and in the manner provided in such Securities. The Issuer shall pay interest (including post-petition interest in any proceeding
under any Bankruptcy Law) on overdue principal on each series of Securities at the rate specified in the terms of such series of Securities to the extent lawful; it shall pay interest (including post-petition interest in any proceeding under any
Bankruptcy Law) on overdue installments of interest (without regard to any applicable grace period) at the same rate to the extent lawful. Unless otherwise provided in the Securities of any series, not later than 10:00 A.M. (New York City time) on
the due date of any principal of or interest on any Securities, the Issuer will deposit with the Trustee (or paying agent) money in immediately available funds sufficient to pay such amounts, provided that if the Issuer or any affiliate of
the Issuer is acting as paying agent, it will, on or before each due date, segregate and hold in a separate trust fund for the benefit of the Holders a sum of money sufficient to pay such amounts until paid to such Holders or otherwise disposed of
as provided in the Indenture. In each case the Issuer will promptly notify the Trustee of its compliance with this paragraph. 

(b) An installment of principal or interest will be considered paid on the date due if the Trustee (or paying agent, other than the
Issuer or any affiliate of the Issuer) holds on that date money designated for and sufficient to pay the installment. If the Issuer or any affiliate of the Issuer acts as paying agent, an installment of principal or interest will be considered paid
on the due date only if paid to the Holders. 
 (c) Payments in respect of the Securities represented by the Global Security are
to be made by wire transfer of immediately available funds to the accounts specified by the Holder of the Global Security. With respect to certificated Securities, the Issuer will make all payments (i) to Holders having an aggregate principal
amount of $5,000,000 or less of such series, by check mailed to the Holders of these Securities at their address as it appears in the Register and (B) to Holders having an aggregate principal amount of more than $5,000,000 of such series,
either by check mailed to the Holders of these Securities or upon application by such a Holder to the Registrar not later than the relevant record date, by wire transfer in immediately available funds to that Holder’s account within the United
States, which application shall remain in effect until the Holder notifies, in writing, the Registrar to the contrary by wire transfer of immediately available funds to the accounts specified by the Holders thereof or, if no such account is
specified, by mailing a check to each Holder’s registered address. 
 Section 3.02. Offices for Payments, etc. So
long as any of the Securities remain Outstanding, the Issuer will maintain in the continental United States of America, the following for each series: an office or agency (a) where the Securities may be presented

  
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for payment or repurchase (a “paying agent”) and, in the case of convertible Securities, for conversion (a “conversion agent”), (b) where the Securities may
be presented for registration of transfer and for exchange as in the Indenture provided and (c) where notices and demands to or upon the Issuer in respect of the Securities or of the Indenture may be given or served. The Issuer will give to the
Trustee written notice of the location of any such office or agency and of any change of location thereof. Unless otherwise specified in accordance with Section 2.03, the Issuer hereby initially designates the Corporate Trust Office of the
Trustee, as the office to be maintained by it for each such purpose. In case the Issuer shall fail to so designate or maintain any such office or agency or shall fail to give such notice of the location or of any change in the location thereof,
presentations and demands may be made and notices may be served at the applicable Corporate Trust Office of the Trustee and the Issuer hereby appoints the Trustee as its agent to receive all such presentations, notices and demands. 

Section 3.03. Paying Agents. Whenever the Issuer shall appoint a paying agent other than the Trustee with respect to the
Securities of any series, it will cause such paying agent to execute and deliver to the Trustee an instrument in which such agent shall agree with the Trustee, subject to the provisions of this Section, 

(a) that it will hold all sums received by it as such agent for the payment of the principal of or interest on the Securities of such
series (whether such sums have been paid to it by the Issuer or by any other obligor on the Securities of such series) in trust for the benefit of the Holders of the Securities of such series or of the Trustee, 

(b) that it will give the Trustee notice of any failure by the Issuer (or by any other obligor on the Securities of such series) to make
any payment of the principal of or interest on the Securities of such series when the same shall be due and payable, 
 (c) pay
any such sums so held in trust by it to the Trustee upon the Trustee’s written request at any time during the continuance of the failure referred to in clause 3.03(b) above, and 

(d) that it will perform all other duties of paying agent as set forth in the Indenture. 

The Issuer shall, on or prior to each due date of the principal of or interest on the Securities of such series, deposit with the paying
agent a sum sufficient to pay such principal or interest so becoming due, and (unless such paying agent is the Trustee) the Issuer shall promptly notify the Trustee of any failure to take such action. 

If an Issuer shall act as its own paying agent with respect to the Securities of any series, it will, on or before each due date of the
principal of or interest on the Securities of such series, set aside, segregate and hold in trust for the benefit of the Holders of the Securities of such series a sum sufficient to pay such principal or interest so becoming due. The Issuer will
promptly notify the Trustee of any failure to take such action. 

  
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 Anything in this section to the contrary notwithstanding, the Issuer may at any time, for
the purpose of obtaining a satisfaction and discharge with respect to one or more or all series of Securities hereunder, or for any other reason, pay, deliver or cause to be paid or delivered to the Trustee all sums or amounts held in trust for any
such series by the Issuer or any paying agent hereunder, as required by this Section, such sums and amounts to be held by the Trustee upon the trusts herein contained. 
 Anything in this section to the contrary notwithstanding, the agreement to hold sums or amounts in trust as provided in this section is subject to the provisions of Section 9.03 and 9.04. 

Section 3.04. Certificate of the Issuer. The Issuer will furnish to the Trustee on or before 120 days after the end of each fiscal
year ending after the date hereof a brief certificate (which need not comply with Section 10.05) from the principal executive, financial or accounting officer or the Treasurer of the Issuer as to his or her knowledge of the Issuer’s
compliance with all conditions and covenants under the Indenture (such compliance to be determined without regard to any period of grace or requirement of notice provided under the Indenture), or if there has been a default, specifying the default
and its nature and status. 
 In addition, the Issuer shall deliver to the Trustee, as soon as possible, and in any event within
30 days after the Issuer becomes aware of the occurrence of any Event of Default or default, an Officer’s Certificate setting forth the details of such Event of Default or default, its status and the action that the Issuer is taking or
proposing to take with respect thereto. 
 Section 3.05. Reports by the Issuer. The Issuer will furnish to the Trustee
any document or report the Issuer is required to file with the Commission pursuant to Section 13 or Section 15(d) of the Exchange Act within 15 days after such document or report is filed with the Commission; provided that in each case the
delivery of materials to the Trustee by electronic means or filing documents pursuant to the Commission’s “EDGAR” system (or any successor electronic filing system) shall be deemed to constitute “filing” with the Trustee for
purposes of this Section 3.05. Delivery of such reports, information and documents to the Trustee is for informational purposes only and the Trustee’s receipt of such shall not constitute constructive notice of any information contained
therein or determinable from information contained therein, including the Company’s compliance with any of its covenants hereunder (as to which the Trustee is entitled to rely exclusively on Officer’s Certificates). 

Section 3.06. Existence. Except as permitted under Article 8, the Issuer covenants to do or cause to be done all things necessary
to preserve and keep in full force and effect its existence, rights and franchises; provided, however, that the Issuer shall not be required to preserve any right or franchise if it determines that its preservation is no longer
desirable in the conduct of business. 

  
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 ARTICLE 4 
 REMEDIES OF THE TRUSTEE AND HOLDERS ON EVENT OF
DEFAULT 
 Section 4.01. Event of Default; Acceleration of Maturity; Waiver of Default. An “Event
of Default” with respect to Securities of any series means the occurrence of one or more of the following events (whatever the reason for such Event of Default and whether it shall be voluntary or involuntary or be effected by operation of
law or pursuant to any judgment, decree or order of any court or any order, rule or regulation of any administrative or governmental body): 
 (a) default in the payment of any installment of interest upon any of the Securities of such series as and when the same shall become due and payable, and continuance of such default for a period of 30
days or more; 
 (b) default in the payment of the principal, or premium, if any, on any of the Securities of such series as and
when the same shall become due and payable either at maturity, upon redemption, upon required repurchase, by declaration or otherwise; 
 (c) default in the payment of any sinking fund installment as and when the same shall become due and payable by the terms of the Securities of such series; 

(d) default in the performance, or breach, of any covenant or warranty of the Issuer in respect of the Securities of such series (other
than defaults pursuant to paragraphs (a), (b) or (c) above), and continuance of such default or breach for a period of 90 days or more after there has been given, by registered or certified mail, to the Issuer by the Trustee or to the
Issuer and the Trustee by the Holders of at least 25% in principal amount of the Securities of all such series affected that is then outstanding (all such series voting together as a single class) thereby, a written notice specifying such default or
breach and requiring it to be remedied and stating that such notice is a “Notice of Default” hereunder; 
 (e)
a court having jurisdiction in the premises shall enter a decree or order for relief in respect of the Issuer in an involuntary case under any applicable bankruptcy, insolvency or other similar law now or hereafter in effect, or appointing a
receiver, liquidator, assignee, custodian, trustee or sequestrator (or similar official) of the Issuer or for any substantial part of its property or ordering the winding up or liquidation of its affairs or the affairs, and such decree or order
shall remain unstayed and in effect for a period of 60 consecutive days; 
 (f) the Issuer shall commence a voluntary case under
any applicable bankruptcy, insolvency or other similar law now or hereafter in effect, or consent to the entry of an order for relief in an involuntary case under any such law, or consent to the appointment of or taking possession by a receiver,
liquidator, assignee, custodian, trustee or sequestrator (or similar official) of the Issuer or for any substantial part of its property, or make any general assignment for the benefit of creditors; 

  
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 (g) any other Event of Default provided in the Officer’s Certificate, supplemental
indenture or Resolution of the Board of Directors under which such series of Securities is issued or in the form of Security for such series. 
 If an Event of Default described in clauses 4.01(a), 4.01(b), 4.01(c), 4.01(d) or 4.01(g) above (if the Event of Default under clause 4.01(d) is with respect to less than all series of Securities then
Outstanding) occurs and is continuing, then, and in each and every such case, unless the principal of all of the Securities of such series shall have already become due and payable, the Trustee may, and at the direction of the Holders of not less
than 25% in aggregate principal amount of the Securities of each such series affected that is then Outstanding hereunder (each such series voting together as a single class) by notice in writing to the Issuer (and to the Trustee if given by
Holders), shall declare the entire principal (or, if the Securities of such series are Original Issue Discount Securities, such portion of the principal amount as may be specified in the terms of such series) of all Outstanding Securities of each
such series, together with all accrued and unpaid interest to be due and payable immediately, and upon any such declaration the same shall become immediately due and payable. 
 If an Event of Default described in clauses 4.01(e) or 4.01(f) above occurs and is continuing, then the entire principal amount of the Outstanding Securities will automatically become due immediately and
payable without any declaration or other act on the part of the Trustee or any Holder. 
 Notwithstanding the foregoing, the
Holders of a majority in principal amount of all series of the Outstanding Securities affected (all such series voting together as a single class) by written notice to the Issuer and to the Trustee may on behalf of the Holders of all Securities of
such series waive all past defaults and rescind and annul a declaration of acceleration and its consequences if: 
 (i) all existing Events of Default, other than the nonpayment of the principal of and interest on the Securities that have become due solely by the declaration of acceleration, have been cured or waived,
and 
 (ii) the rescission would not conflict with any judgment or decree. 

For all purposes under the Indenture, if a portion of the principal of any Original Issue Discount Securities shall have been accelerated
and declared due and payable pursuant to the provisions hereof, then, from and after such declaration, unless such declaration has been rescinded and annulled, the principal amount of such Original Issue Discount Securities shall be deemed, for all
purposes hereunder, to be such portion of the principal thereof as shall be due and payable as a result of such acceleration, and payment of such portion of the principal thereof as shall be due and payable as a result of such acceleration, together
with interest, if any, thereon and all other amounts owing thereunder, shall constitute payment in full of such Original Issue Discount Securities. 

  
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 Section 4.02. Collection of Indebtedness by Trustee; Trustee May Prove Debt. The
Issuer covenants that (a) in case default shall be made in the payment of any installment of interest on any of the Securities of any series when such interest shall have become due and payable, and such default shall have continued for a
period of 30 days or (b) in case default shall be made in the payment of all or any part of the principal of any of the Securities of any series when the same shall have become due and payable, whether upon maturity of the Securities of such
series or upon any redemption, required repurchase or by declaration or otherwise—then upon demand of the Trustee, the Issuer will pay to the Trustee for the benefit of the Holders of the Securities of such series the whole amount that then
shall have become due and payable on all Securities of such series for principal or interest, as the case may be (with interest to the date of such payment upon the overdue principal and, to the extent that payment of such interest is enforceable
under applicable law, on overdue installments of interest at the same rate as the rate of interest or Yield to Maturity (in the case of Original Issue Discount Securities) specified in the Securities of such series); and in addition thereto, such
further amount as shall be sufficient to cover the costs and expenses of collection, including reasonable compensation to the Trustee and each predecessor Trustee, their respective agents, attorneys and counsel, and any expenses and liabilities
incurred by the Trustee and each predecessor Trustee except as a result of its negligence or bad faith. 
 Until such demand is
made by the Trustee, the Issuer may pay the principal of and interest on the Securities of any series to the Holders, whether or not the principal of and interest on the Securities of such series be overdue. 

In case the Issuer shall fail forthwith to pay such amounts upon such demand, the Trustee, in its own name and as trustee of an express
trust, shall be entitled and empowered to institute any action or proceedings at law or in equity for the collection of the sums so due and unpaid, and may prosecute any such action or proceedings to judgment or final decree, and may enforce any
such judgment or final decree against the Issuer or other obligor upon such Securities and collect in the manner provided by law out of the property of the Issuer or other obligor upon such Securities, wherever situated, the amounts adjudged or
decreed to be payable. 
 In case there shall be pending proceedings relative to the Issuer or any other obligor upon the
Securities under Bankruptcy Law, or in case a receiver, assignee or trustee in bankruptcy or reorganization, liquidator, sequestrator or similar official shall have been appointed for or taken possession of the Issuer or its property or such other
obligor, or in case of any other comparable judicial proceedings relative to the Issuer or other obligor upon the Securities of any series, or to the creditors or property of the Issuer or such other obligor, the Trustee, irrespective of whether the
principal of any Securities shall then be due and payable as therein expressed or by declaration or otherwise and irrespective of whether the Trustee shall have made any demand pursuant to the provisions of this Section, shall be entitled and
empowered, by intervention in such proceedings or otherwise: 

  
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 (a) to file and prove a claim or claims for the whole amount of principal
and interest (or, if the Securities of any series are Original Issue Discount Securities, such portion of the principal amount as may be specified in the terms of such series) owing and unpaid in respect of the Securities of any series, and to file
such other papers or documents as may be necessary or advisable in order to have the claims of the Trustee (including any claim for reasonable compensation to the Trustee and each predecessor Trustee, and their respective agents, attorneys and
counsel, and for reimbursement of all expenses and liabilities incurred, and all advances made, by the Trustee and each predecessor Trustee, except as a result of negligence or bad faith) and of the Holders allowed in any judicial proceedings
relative to the Issuer or other obligor upon the Securities of any series, or to the creditors or property of the Issuer or such other obligor, 
 (b) unless prohibited by applicable law and regulations, to vote on behalf of the Holders of the Securities of any series in any election of a trustee or a standby trustee in arrangement, reorganization,
liquidation or other bankruptcy or insolvency proceedings or Person performing similar functions in comparable proceedings, and 
 (c) to collect and receive any cash or other property payable or deliverable on any such claims, and to distribute all amounts received with respect to the claims of the Holders and of the Trustee on
their behalf; and any trustee, receiver, or liquidator, custodian or other similar official is hereby authorized by each of the Holders to make payments to the Trustee, and, in the event that the Trustee shall consent to the making of payments
directly to the Holders, to pay to the Trustee such amounts as shall be sufficient to cover reasonable compensation to the Trustee, each predecessor Trustee and their respective agents, attorneys and counsel, and all other expenses and liabilities
incurred, and all advances made, by the Trustee and each predecessor Trustee except as a result of negligence or bad faith and all other amounts due to the Trustee or any predecessor Trustee pursuant to Section 5.07. 

Nothing herein contained shall be deemed to authorize the Trustee to authorize or consent to or vote for or accept or adopt on behalf of
any Holder any plan or reorganization, arrangement, adjustment or composition affecting the Securities of any series or the rights of any Holder thereof, or to authorize the Trustee to vote in respect of the claim of any Holder in any such
proceeding except, as aforesaid, to vote for the election of a trustee in bankruptcy or similar Person. 
 All rights of action
and of asserting claims under the Indenture, or under any of the Securities, may be enforced by the Trustee without the possession of any of the Securities or the production thereof on any trial or other proceedings relative thereto, and any such
action or proceedings instituted by the Trustee shall be brought in its own name as trustee of an express trust, and any recovery of judgment, subject to the payment of the 

  
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reasonable expenses, disbursements and compensation of the Trustee, each predecessor Trustee and their respective agents and attorneys, shall be for the ratable benefit of the holders of the
Securities in respect of which such action was taken. 
 In any proceedings brought by the Trustee (and also any proceedings
involving the interpretation of any provision of the Indenture to which the Trustee shall be a party) the Trustee shall be held to represent all the Holders of the Securities in respect to which such action was taken, and it shall not be necessary
to make any Holders of such Securities parties to any such proceedings. 
 Section 4.03. Application of Proceeds. Any
sums or amounts collected by the Trustee pursuant to this Article in respect of any series shall be applied in the following order at the date or dates fixed by the Trustee and, in case of the distribution of such property on account of principal or
interest (or amounts due upon conversion), upon presentation of the several Securities in respect of which property has been collected and stamping (or otherwise noting) thereon the payment, or issuing Securities of such series in reduced principal
amounts in exchange for the presented Securities of like series if only partially paid, or upon surrender thereof if fully paid: 
 FIRST: To the payment of costs and expenses applicable to such series in respect of which property has been collected, including reasonable compensation to the Trustee and each predecessor Trustee and
their respective agents and attorneys and of all expenses and liabilities incurred by the Trustee and each predecessor Trustee except as a result of negligence or bad faith, and all other amounts due to the Trustee or any predecessor Trustee
pursuant to Section 5.07; 
 SECOND: In case the principal of the Securities of such series in respect of
which property has been collected shall not have become and be then due and payable, to the payment of interest on, and any cash due upon conversion of, the Securities of such series in default in the order of the maturity of the installments of
such interest and cash due upon conversion, with interest (to the extent that such interest has been collected by the Trustee) upon the overdue payments at the same rate as the rate of interest or Yield to Maturity (in the case of Original Issue
Discount Securities) specified in such Securities, such payments to be made ratably to the Persons entitled thereto, without discrimination or preference; 
 THIRD: In case the principal of the Securities of such series in respect of which property has been collected shall have become and shall be then due and payable, to the payment of the whole amount
(including, if applicable, any cash due upon conversion) then owing and unpaid upon all the Securities of such series for principal and interest, with interest upon the overdue principal, and (to the extent that such interest has been collected by
the Trustee) upon overdue installments of interest at the same rate as the rate of interest or Yield to Maturity (in the case of Original Issue Discount Securities) specified in the Securities of such series; and in case such property shall be
insufficient to pay in full the whole 

  
 26 

 
amount so due and unpaid upon the Securities of such series, then to the payment of such principal (including, if applicable, the cash due upon conversion) and interest or Yield to Maturity,
without preference or priority of principal over interest or Yield to Maturity, or of interest or Yield to Maturity over principal, or of any installment of interest over any other installment of interest, or of any Security of such series over any
other Security of such series, ratably to the aggregate of such principal (including, if applicable, the cash due upon conversion) and accrued and unpaid interest or Yield to Maturity; and 

FOURTH: To the payment of the remainder, if any, to the Issuer or any other Person lawfully entitled thereto. 

Section 4.04. Suits for Enforcement. In case an Event of Default has occurred, has not been waived and is continuing, the Trustee
may in its discretion proceed to protect and enforce the rights vested in it by the Indenture by such appropriate judicial proceedings as the Trustee shall deem most effectual to protect and enforce any of such rights, either at law or in equity or
in bankruptcy or otherwise, whether for the specific enforcement of any covenant or agreement contained in the Indenture or in aid of the exercise of any power granted in the Indenture or to enforce any other legal or equitable right vested in the
Trustee by the Indenture or by law. 
 Section 4.05. Restoration of Rights on Abandonment of Proceedings. In case the
Trustee shall have proceeded to enforce any right under the Indenture and such proceedings shall have been discontinued or abandoned for any reason, or shall have been determined adversely to the Trustee, then and in every such case the Issuer and
the Trustee shall be restored respectively to their former positions and rights hereunder, and all rights, remedies and powers of the Issuer, the Trustee and the Holders shall continue as though no such proceedings had been taken. 

Section 4.06. Limitations on Suits by Holder. No Holder of any Security of any series shall have any right by virtue or by availing
of any provision of the Indenture to institute any action or proceeding at law or in equity or in bankruptcy or otherwise upon or under or with respect to the Indenture, or for the appointment of a trustee, receiver, liquidator, custodian or other
similar official or for any other remedy hereunder, unless (i) such Holder previously shall have given to the Trustee written notice of default and of the continuance thereof, as hereinbefore provided; (ii) the Holders of not less than 25%
in aggregate principal amount of the Securities of all such series affected that is then Outstanding (voting together as a single class) shall have made written request upon the Trustee to institute such action or proceedings in its own name as
Trustee hereunder; (iii) such Holder or Holders shall have offered to the Trustee security or indemnity reasonably satisfactory to it against the costs, expenses and liabilities to be incurred in compliance with such request; (iv) the
Trustee for 60 days after its receipt of such notice, request and offer of indemnity shall have failed to institute any such action or proceeding; and (v) no direction inconsistent with such written request shall have been given to the Trustee
during such 60-day period by the Holders of a majority in aggregate principal amount of 

  
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the Securities of all series affected then Outstanding. It is understood and intended, and expressly covenanted by the taker and Holder of every Security with every other taker and Holder and the
Trustee, that no one or more Holders of any series shall have any right in any manner whatever by virtue or by availing of any provision of the Indenture to affect, disturb or prejudice the rights of any other such Holder, or to obtain or seek to
obtain priority over or preference to any other such Holder or to enforce any right under the Indenture, except in the manner herein provided and for the equal, ratable and common benefit of all Holders of the applicable series. For the protection
and enforcement of the provisions of this Section, each and every Holder and the Trustee shall be entitled to such relief as can be given either at law or in equity. 
 Section 4.07. Unconditional Right of Holders to Institute Certain Suits. Notwithstanding any other provision in the Indenture and any provision of any Security, the right of any Holder of any
Security to receive payment of the principal of and interest on such Security on or after the respective due dates expressed in such Security (or, in the case of convertible Securities, to receive the consideration due upon conversion), or to
institute suit for the enforcement of any such payment (or delivery) on or after such respective dates, shall not be impaired or affected without the consent of such Holder. 
 Section 4.08. Powers and Remedies Cumulative; Delay or Omission Not Waiver of Default. Except as provided in Section 4.06, no right or remedy herein conferred upon or reserved to the Trustee
or to the Holders is intended to be exclusive of any other right or remedy, and every right and remedy shall, to the extent permitted by law, be cumulative and in addition to every other right and remedy given hereunder or now or hereafter existing
at law or in equity or otherwise. The assertion or employment of any right or remedy hereunder, or otherwise, shall not prevent the concurrent assertion or employment of any other appropriate right or remedy. 

No delay or omission of the Trustee or of any Holder to exercise any right or power accruing upon any Event of Default occurring and
continuing as aforesaid shall impair any such right or power or shall be construed to be a waiver of any such Event of Default or an acquiescence therein; and, subject to Section 4.06, every power and remedy given by the Indenture or by law to
the Trustee or to the Holders may be exercised from time to time, and as often as shall be deemed expedient, by the Trustee or by the Holders. 
 Section 4.09. Control by Holders. The Holders of a majority in aggregate principal amount of the Securities of all series affected (voting together as a single class) at the time Outstanding shall
have the right to direct the time, method, and place of conducting any proceeding for any remedy available to the Trustee, or exercising any trust or power conferred on the Trustee with respect to the Securities of each such affected series by the
Indenture; provided, however, that such direction shall not be otherwise than in accordance with law and the provisions of the Indenture. Subject to the provisions of Section 5.01, the Trustee shall have the right to decline to
follow any such direction if the Trustee, being advised by counsel, shall determine that the action or proceeding so directed may not lawfully be taken or if the Trustee in good faith shall 

  
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determine that the action or proceedings so directed would involve the Trustee in personal liability or if the Trustee in good faith shall determine that the actions or forbearances specified in
or pursuant to such direction would be unduly prejudicial to the interests of Holders of the Securities of all series so affected not joining in the giving of said direction, it being understood that (subject to Section 5.01) the Trustee shall
have no duty to ascertain whether or not such actions or forbearances are unduly prejudicial to such Holders. 
 Nothing in the
Indenture shall impair the right of the Trustee in its discretion to take any action deemed proper by the Trustee and which is not inconsistent with such direction or directions by Holders. 

Section 4.10. Waiver of Past Defaults. Except as otherwise provided in Sections 4.01, 4.07 and 7.02, the Holders of a
majority in aggregate principal amount of the Outstanding Securities of one or more series (voting together as a single class) may, by notice to the Trustee, on behalf of the Holders of all Securities of each such series waive an existing default
and its consequences. Upon such waiver, the default will cease to exist, and any Event of Default arising therefrom will be deemed to have been cured, but no such waiver will extend to any subsequent or other default or impair any right consequent
thereon. 
 Section 4.11. Trustee to Give Notice of Default, But May Withhold in Certain Circumstances. The Trustee shall
give to the Holders of any series, as the names and addresses of such Holders appear on the Register, notice by mail of all defaults known to the Trustee which have occurred with respect to such series, such notice to be transmitted within 60 days
after the occurrence thereof, unless such defaults shall have been cured before the giving of such notice (the term “default” or “defaults” for the purposes of this section being hereby defined to mean any event or condition
which is, or with notice or lapse of time or both would become, an Event of Default); provided that, except in the case of default in the payment of the principal of or interest on any of the Securities of such series, the payment or delivery of the
consideration due upon conversion of any of the Securities of such series, or in the payment of any sinking or purchase fund installment with respect to the Securities of such series, the Trustee shall be protected in withholding such notice if and
so long as the board of directors, the executive committee, or a trust committee of directors or trustees and/or responsible officers of the Trustee in good faith determines that the withholding of such notice is in the interests of the Holders of
such series. 
 Section 4.12. Right of Court to Require Filing of Undertaking to Pay Costs. In any suit for the
enforcement of any right or remedy under the Indenture or in any suit against the Trustee for any action taken or omitted by it as Trustee, a court may require any party litigant in such suit (other than the Trustee) to file an undertaking to pay
the costs of the suit, and the court may assess reasonable costs, including reasonable attorneys fees, against any party litigant (other than the Trustee) in the suit having due regard to the merits and good faith of the claims or defenses made by
the party litigant. 

  
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This Section does not apply to a suit by a Holder to enforce payment of principal of or interest on any Security on the respective due dates or to enforce the right to convert any Security in
accordance with its terms and the terms of the Indenture. 
 ARTICLE 5 

CONCERNING THE TRUSTEE 

Section 5.01. Duties and Responsibilities of the Trustee; During Default; Prior to Default. 

(a) The duties and responsibilities of the Trustee are as provided by the Trust Indenture Act and as set forth herein. Whether or not
expressly so provided, every provision of the Indenture relating to the conduct or affecting the liability of or affording protection to the Trustee is subject to this Article 5. 

(b) Except during the continuance of an Event of Default, the Trustee need perform only those duties that are specifically set forth in
the Indenture and no others, and no implied covenants or obligations will be read into the Indenture against the Trustee. In case an Event of Default has occurred and is continuing, the Trustee shall exercise those rights and powers vested in it by
the Indenture, and use the same degree of care and skill in their exercise, as a prudent person would exercise or use under the circumstances in the conduct of such person’s own affairs. 

(c) No provision of the Indenture shall be construed to relieve the Trustee from liability for its own negligent action, its own
negligent failure to act or its own willful misconduct, provided that: 
 (i) this subsection (c) shall not
be construed to limit the effect of subsection (b) of this (a)Section 5.01; 
 (ii) the Trustee shall not
be liable for any error of judgement made in good faith by a Responsible Officer, unless it shall be proved that the Trustee was negligent in ascertaining the pertinent facts; and 

(iii) no provision of the Indenture shall require the Trustee to expend or risk its own funds or otherwise incur any
financial liability in the performance of any of its duties hereunder, or in the exercise of any of its rights or powers, if it shall have reasonable grounds for believing that repayment of such funds or adequate indemnity against such risk or
liability is not reasonably assured to it. 
 Section 5.02. Trustee’s Obligations with Respect to the Covenants. The
Trustee shall not be obligated to monitor or confirm, on a continuing basis or otherwise, the Issuer’s compliance with the covenants contained in Article 4 or with respect to any reports or other documents filed under the Indenture;
provided, however, that nothing herein shall relieve the Trustee of any obligations to monitor the Issuer’s timely delivery of all reports and certificates required under Sections 3.04 and 3.05 of the Indenture and to fulfill its
obligations under Article 5 hereof. 

  
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 Section 5.03. Property Held by Trustee. Subject to the provisions of
Section 9.04 hereof, all property received by the Trustee shall, until used or applied as herein provided, be held in trust for the purposes for which they were received, but need not be segregated from other funds except to the extent required
by law. Neither the Trustee nor any agent of the Issuer or the Trustee shall be liable for interest on any money received by it hereunder except such as it may agree with the Issuer in writing to pay thereon. 

Section 5.04. Reports by the Trustee to Holders. Within 60 days after each November 15, beginning with November 15,
2012, the Trustee will mail to each Holder, as provided in Trust Indenture Act Section 313(c), a brief report dated as of such November 15, if required by Trust Indenture Act Section 313(a), and file such reports with each stock
exchange upon which its Securities are listed and with the Commission if, and to the extent, required by Trust Indenture Act Section 313(d). 
 The Trustee shall comply with Section 313(b) and 313(c) of the Trust Indenture Act. 
 A copy of each such report shall, at the time of such transmission to Holders, be filed by the Trustee with the Issuer, with each stock exchange upon which any Securities are listed (if so listed) and
also with the Commission. 
 Section 5.05. Certain Rights of the Trustee. Subject to Trust Indenture Act Sections 315(a)
through (d): 
 (a) In the absence of bad faith on its part, the Trustee may rely, and will be protected in acting or refraining
from acting, upon any resolution, certificate, statement, instrument, opinion, report, notice, request, direction, consent, order, bond, debenture, note, other evidence of indebtedness or other paper or document believed by it to be genuine and to
have been signed or presented by the proper Person. The Trustee need not investigate any fact or matter stated in the document, but, in the case of any document which is specifically required to be furnished to the Trustee pursuant to any provision
hereof, the Trustee shall examine the document to determine whether it conforms to the requirements of the Indenture (but need not confirm or investigate the accuracy of mathematical calculations or other facts stated therein). The Trustee, in its
discretion, may make further inquiry or investigation into such facts or matters as it sees fit, and, if the Trustee shall determine to make such further inquiry or investigation, it shall be entitled to examine the books, records and premises of
the Company, personally or by agent or attorney at the sole cost of the Company and shall incur no liability or additional liability of any kind by reason of such inquiry or investigation. 

  
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 (b) Before the Trustee acts or refrains from acting, it may require an Officer’s
Certificate or an Opinion of Counsel conforming to Section 10.05, and the Trustee will not be liable for any action it takes or omits to take in good faith in reliance on the certificate or opinion. 

(c) The Trustee may act through its attorneys and agents and will not be responsible for the misconduct or negligence of any attorney or
agent appointed by the Trustee with due care. 
 (d) The Trustee will be under no obligation to exercise any of the rights or
powers vested in it by the Indenture or to institute, conduct or defend any litigation hereunder or in relation hereto at the request or direction of any of the Holders, unless such Holders have offered to the Trustee security or indemnity
reasonably satisfactory to it against the costs, expenses and liabilities that might be incurred by it in compliance with such request or direction. 
 (e) The Trustee will not be liable in its individual capacity for any action it takes, suffers or omits to take in good faith that it believes to be authorized or within its rights or powers or for any
action it takes or omits to take in accordance with the direction of the Holders in accordance with Section 4.09 relating to the time, method and place of conducting any proceeding for any remedy available to the Trustee, or exercising any
trust or power conferred upon the Trustee, under the Indenture. 
 (f) The Trustee may consult with counsel, and any advice of
such counsel or any Opinion of Counsel will be full and complete authorization and protection in respect of any action taken, suffered or omitted by it hereunder in good faith and in reliance thereon. 

(g) No provision of the Indenture will require the Trustee to expend or risk its own funds or otherwise incur any financial liability in
the performance of its duties hereunder, or in the exercise of its rights or powers, unless it receives indemnity satisfactory to it against any loss, liability or expense. 
 (h) The Trustee shall not be liable in its individual capacity for an error in judgment made in good faith by a Responsible Officer or other officers of the Trustee, unless it shall be proved that the
Trustee was negligent in ascertaining the pertinent facts. 
 (i) The Trustee shall have no duty to see to any recording, filing
or depositing of the Indenture or any agreement referred to herein or any financing statement or continuation statement evidencing a security interest, or to see to the maintenance of any such re-recording or re-filing or re-depositing thereof.

 (j) The Trustee shall not be required to take notice or be deemed to have notice or knowledge of any default or Event of
Default unless a Responsible Officer of the Trustee shall have received written notice from the Issuer or any Holder of the Securities or obtained actual knowledge thereof. In the absence of receipt of such notice or actual knowledge, the Trustee
may conclusively assume that there is no default or Event of Default. 

  
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 (k) In no event shall the Trustee be responsible or liable for any failure or delay in the
performance of its obligations hereunder arising out of or caused by, directly or indirectly, forces beyond its control, including, without limitation, strikes, work stoppages, accidents, acts of war or terrorism, civil or military disturbances,
nuclear or natural catastrophes or acts of God, and interruptions, loss or malfunctions of utilities, communications or computer (software and hardware) services; it being understood that the Trustee shall use reasonable efforts which are consistent
with accepted practices in the banking industry to resume performance as soon as practicable under the circumstances. 
 (l) The
rights, privileges, protections, immunities and benefits given to the Trustee, including, without limitation, its right to be indemnified, are extended to, and shall be enforceable by, the Trustee in each of its capacities hereunder, and each agent,
custodian and other Person employed to act hereunder. 
 (m) The Trustee may request that the Issuer deliver a certificate
setting forth the names of individuals and/or titles of officers authorized at such time to take specified actions pursuant to the Indenture. 
 (n) Any request or direction of the Issuer mentioned herein shall be sufficiently evidenced by an Issuer Order and any resolution of the Board of Directors may be sufficiently evidenced by a Resolution of
the Board of Directors. 
 Section 5.06. Trustee and Agents May Hold Securities; Collections, etc. The Trustee or any
agent of the Issuer or the Trustee, in its individual or any other capacity, may become the owner or pledgee of Securities with the same rights it would have if it were not the Trustee or such agent and may otherwise deal with the Issuer and
receive, collect, hold and retain collections from the Issuer with the same rights it would have if it were not the Trustee or such agent. 
 Section 5.07. Compensation and Indemnification of Trustee and Its Prior Claim. (a) The Issuer will pay the Trustee compensation as agreed upon in writing for its services. The compensation of
the Trustee is not limited by any law on compensation of a trustee of an express trust. The Issuer will reimburse the Trustee upon request for all reasonable out-of-pocket expenses, disbursements and advances incurred or made by the Trustee,
(including the reasonable compensation and the expenses and disbursements of its counsel and of all agents and other Persons not regularly in its employ) except to the extent any such expense, disbursement or advance may arise from its negligence or
bad faith. The Issuer also covenants to indemnify the Trustee, its directors, officers, employees and agents and each predecessor Trustee, its directors, officers, employees and agents for, and to hold each of them harmless against, any loss,
liability or expense 

  
 33 

 
arising out of or in connection with the acceptance or administration of the Indenture or the trusts hereunder and the performance of its duties hereunder and under the Securities, including the
costs and expenses of defending itself against or investigating any claim of liability in the premises and the costs and expenses of defending itself against any claim or liability and of complying with any process served upon it or any of its
officers, except to the extent such loss liability or expense is due to the negligence or bad faith of the Trustee or such predecessor Trustee. 
 Anything in the Indenture to the contrary notwithstanding, in no event shall the Trustee be liable for special, indirect or consequential loss or damage of any kind whatsoever (including but not limited
to lost profits) unless it shall be proved that the Trustee acted in bad faith or was grossly negligent in acting or failing to act. 
 (b) To secure the Issuer’s payment obligations in this Section, the Trustee will have a lien prior to the Securities on all money or property held or collected by the Trustee, in its capacity as
Trustee, except money or property held in trust to pay principal of, and interest on particular Securities. 
 The obligations
of the Issuer under this Section 5.07 shall survive the resignation and removal of the Trustee, payment of the Securities and termination of the Indenture, and shall extend to any co-trustee or separate trustee. 

Section 5.08. Right of Trustee to Rely on Officer’s Certificate, etc. Subject to Sections 5.01 and 5.05, whenever in the
administration of the trusts of the Indenture the Trustee shall deem it necessary or desirable that a matter be proved or established prior to taking or suffering or omitting any action hereunder, such matter (unless other evidence in respect
thereof be herein specifically prescribed) may, in the absence of negligence or bad faith on the part of the Trustee, be deemed to be conclusively proved and established by an Officer’s Certificate delivered to the Trustee, and such
certificate, in the absence of negligence or bad faith on the part of the Trustee, shall be full warrant to the Trustee for any action taken, suffered or omitted by it under the provisions of the Indenture upon the faith thereof. 

Section 5.09. Disqualification; Conflicting Interests. If the Trustee has or shall acquire any “conflicting interest”
within the meaning of Section 310(b) of the Trust Indenture Act, the Trustee and the Issuer shall in all respects comply with the provisions of Section 310(b) of the Trust Indenture Act.  

Section 5.10. Persons Eligible for Appointment as Trustee. The Indenture must always have a Trustee that satisfies the
requirements of Trust Indenture Act Section 310(a) and has a combined capital and surplus of at least $25,000,000 as set forth in its most recent published annual report of condition. 

Section 5.11. Resignation and Removal; Appointment of Successor Trustee. (a) The Trustee, or any trustee or trustees
hereafter appointed, may at any time resign with 

  
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respect to one or more or all series of Securities by giving written notice of resignation to the Issuer and by mailing notice thereof by first class mail to Holders of the applicable series of
Securities at their last addresses as they shall appear on the Register. Upon receiving such notice of resignation, the Issuer shall promptly appoint a successor trustee or trustees with respect to the applicable series by written instrument in
duplicate, executed by authority of the Board of Directors, one copy of which instrument shall be delivered to the resigning Trustee and one copy to the successor trustee or trustees. If no successor trustee shall have been so appointed with respect
to any series and have accepted appointment within 30 days after the mailing of such notice of resignation, the resigning Trustee may petition any court of competent jurisdiction for the appointment of a successor trustee, or any Holder who has been
a bona fide Holder of a Security or Securities of the applicable series for at least six months may, subject to the provisions of Section 4.12, on behalf of himself and all others similarly situated, petition any such court for the
appointment of a successor trustee. Such court may thereupon, after such notice, if any, as it may deem proper and prescribe, appoint a successor trustee. 
 (b) In case at any time any of the following shall occur: 
 (i)
the Trustee shall fail to comply with the provisions of Section 310(b) of the Trust Indenture Act with respect to any series of Securities after written request therefor by the Issuer or by any Holder who has been a bona fide Holder of a
Security or Securities of such series for at least six months; or 
 (ii) the Trustee shall cease to be eligible
in accordance with the provisions of Section 310(a) of the Trust Indenture Act and shall fail to resign after written request therefor by the Issuer or by any Holder; or 

(iii) the Trustee shall become incapable of acting with respect to any series of Securities, or shall be adjudged a
bankrupt or insolvent, or a receiver or liquidator of the Trustee or of its property shall be appointed, or any public officer shall take charge or control of the Trustee or of its property or affairs for the purpose of rehabilitation, conservation
or liquidation; 
 then, in any such case, the Issuer may remove the Trustee with respect to the applicable series of Securities and appoint a
successor trustee for such series by written instrument, in duplicate, executed by order of the Board of Directors of the Issuer, one copy of which instrument shall be delivered to the Trustee so removed and one copy to the successor trustee, or any
Holder who has been a bona fide Holder of a Security or Securities of such series for at least six months may on behalf of himself and all others similarly situated, petition any court of competent jurisdiction for the removal of the Trustee
and the appointment of a successor trustee with respect to such series. Such court may thereupon, after such notice, if any, as it may deem proper and prescribe, remove the Trustee and appoint a successor trustee. 

  
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 (c) The Holders of a majority in aggregate principal amount of the Securities of all series
at the time Outstanding (voting together as a single class) may at any time remove the Trustee with respect to Securities of such series and appoint a successor Trustee with respect to the Securities of such series with the consent of the Issuer by
delivering to the Trustee so removed, to the successor Trustee so appointed and to the Issuer the evidence provided for in Section 6.01 of the action in that regard taken by the Holders. 

(d) Any resignation or removal of the Trustee with respect to any series and any appointment of a successor Trustee with respect to such
series pursuant to any of the provisions of this Section 5.11 shall become effective upon acceptance of appointment by the successor Trustee as provided in Section 5.12. 

(e) Any successor Trustee appointed pursuant to this Section may be appointed with respect to the Securities of one or more series or all
of such series, and at any time there shall be only one Trustee with respect to the Securities of any particular series. 

Section 5.12 . Acceptance of Appointment by Successor. Any successor Trustee appointed as provided in Section 5.11 shall
execute and deliver to the Issuer and to its predecessor Trustee an instrument accepting such appointment hereunder, and thereupon the resignation or removal of the predecessor Trustee with respect to all or any applicable series shall become
effective and such successor Trustee, without any further act, deed or conveyance, shall become vested with all rights, powers, duties and obligations with respect to such series of its predecessor hereunder, with like effect as if originally named
as trustee for such series hereunder; but, nevertheless, on the written request of the Issuer or of the successor Trustee, upon payment of its charges then unpaid, the Trustee ceasing to act shall, subject to Section 9.04, pay over or deliver
to the successor Trustee all property at the time held by it hereunder and shall execute and deliver an instrument transferring to such successor Trustee all such rights, powers, duties and obligations. 

If a successor Trustee is appointed with respect to the Securities of one or more (but not all) series, the Issuer, the predecessor
Trustee and each successor Trustee with respect to the Securities of any applicable series shall execute and deliver an indenture supplemental hereto prepared by and at the expense of the Issuer which (1) shall contain such provisions as shall
be deemed necessary or desirable to transfer and confirm to, and to vest in, each successor Trustee all the rights, powers, trusts and duties of the retiring Trustee with respect to the Securities of that or those series to which the appointment of
such successor Trustee relates, (2) shall contain such provisions as shall be deemed necessary or desirable to confirm that all the rights, powers, trusts and duties of the predecessor Trustee with respect to the Securities of any series as to
which the predecessor Trustee is not retiring shall continue to be vested in the predecessor Trustee, and (3) shall add to or change any of the provisions of the Indenture as shall be necessary to provide for or facilitate the administration of
the trusts hereunder by more than one trustee, it being understood that nothing herein or in such supplemental indenture shall constitute such trustees co-trustees of the same trust and that each such trustee shall be trustee of a trust or trusts
under separate indentures. 

  
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 Upon acceptance of appointment by any successor Trustee as provided in this
Section 5.12, the Issuer shall mail notice thereof by first-class mail to the Holders of any series for which such successor Trustee is acting as trustee at their last addresses as they shall appear in the Register. If the acceptance of
appointment is substantially contemporaneous with the resignation, then the notice called for by the preceding sentence may be combined with the notice called for by Section 5.11. If the Issuer fails to mail such notice within ten days after
acceptance of appointment by the successor Trustee, the successor Trustee shall cause such notice to be mailed at the expense of the Issuer. 
 Section 5.13. Merger, Conversion, Consolidation or Succession to Business of Trustee. If the Trustee consolidates with, merges or converts into, or transfers all or substantially all of its
corporate trust business to, another corporation or national banking association, the resulting, surviving or transferee corporation or national banking association without any further act will be the successor Trustee with the same effect as if the
successor Trustee had been named as the Trustee in the Indenture. 
 In case at the time such successor to the Trustee shall
succeed to the trusts created by the Indenture any of the Securities of any series shall have been authenticated but not delivered, any such successor to the Trustee may adopt the certificate of authentication of any predecessor Trustee and deliver
such Securities so authenticated; and, in case at that time any of the Securities of any series shall not have been authenticated, any successor to the Trustee may authenticate such Securities either in the name of any predecessor hereunder or in
the name of the successor Trustee; and in all such cases such certificate shall have the full force which it is anywhere in the Securities of such series or in the Indenture provided that the certificate of the Trustee shall have; provided,
that the right to adopt the certificate of authentication of any predecessor Trustee or to authenticate Securities of any series in the name of any predecessor Trustee shall apply only to its successor or successors by merger, conversion or
consolidation. 
 Section 5.14. Preferential Collection of Claims Against the Issuer. The Trustees shall comply with
Section 311(a) of the Trust Indenture Act, excluding any creditor relationship described in Section 311(b) of the Trust Indenture Act. A Trustee who has resigned or been removed shall be subject to Section 311(a) of the Trust
Indenture Act to the extent included therein. 
 Section 5.15. Trustee’s Disclaimer. The Trustee (i) makes no
representation as to the validity or adequacy of the Indenture or the Securities, (ii) is not accountable for the Issuer’s use or application of the proceeds from the Securities and (iii) is not responsible for any statement in the
Securities other than its certificate of authentication. 

  
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 ARTICLE 6 
 CONCERNING THE HOLDERS 
 Section
6.01. Evidence of Action Taken by Holders. Any request, demand, authorization, direction, notice, consent, waiver or other action provided by the Indenture to be given or taken by a specified percentage in principal amount of the Holders of
any or all series may be embodied in and evidenced by one or more instruments of substantially similar tenor signed by such specified percentage of Holders in person or by agent duly appointed in writing; and, except as herein otherwise expressly
provided, such action shall become effective when such instrument or instruments are delivered to the Trustee. 
 If the Issuer
shall solicit from the Holders of any series any request, demand, authorization, direction, notice, consent, waiver or other action, the Issuer may, at its option, as evidenced by an Officer’s Certificate, fix in advance a record date for such
series for the determination of Holders entitled to give such request, demand, authorization, direction, notice, consent, waiver or other action, but the Issuer shall have no obligation to do so. If such a record date is fixed, such request, demand,
authorization, direction, notice, consent, waiver or other action, may be given before or after the record date, but only the Holders of the requisite proportion of Outstanding Securities of that series who have authorized or agreed or consented to
such request, demand, authorization, direction, notice, consent, waiver or other action, and for that purpose the Outstanding Securities of that series shall be computed as of the record date; provided, however, that no such
authorization, agreement or consent by such Holders on the record date shall be deemed effective unless it shall become effective pursuant to the provisions of the Indenture not later than six months after the record date. 

Proof of execution of any instrument or of a writing appointing any such agent shall be sufficient for any purpose of the Indenture and
(subject to Sections 5.01 and 5.05) conclusive in favor of the Trustee and the Issuer, if made in the manner provided in this Article. 
 Section 6.02. Proof of Execution of Instruments and of Holding of Securities; Record Date. Subject to Sections 5.01 and 5.05, the execution of any instrument by a Holder or his agent or proxy may
be proved in accordance with such reasonable rules and regulations as may be prescribed by the Trustee or in such manner as shall be satisfactory to the Trustee. The holding of Securities shall be proved by the Register or by a certificate of the
registrar thereof. The Issuer may set a record date for purposes of determining the identity of Holders of any series entitled to vote or consent to any action referred to in Section 6.01, which record date may be set at any time or from time
to time by notice to the Trustee, for any date or dates (in the case of any adjournment or reconsideration) not more than 60 days nor less than five days prior to the proposed date of such vote or consent, and thereafter, notwithstanding any other
provisions hereof, only Holders of such series of record on such record date shall be entitled to so vote or give such consent or revoke such vote or consent. Notice of such record date may be given before or after any request for any action
referred to in Section 6.01 is made by the Issuer. 

  
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 Section 6.03. Holders to Be Treated as Owners. Prior to the due presentment for
registration of transfer of any Security, the Issuer, the Trustee and any agent of the Issuer or the Trustee may deem and treat the Person in whose name any Security shall be registered upon the Register for such series as the absolute owner of such
Security (whether or not such Security shall be overdue and notwithstanding any notation of ownership or other writing thereon) for the purpose of receiving payment of or on account of the principal of, and, subject to the provisions of the
Indenture, interest on such Security, for conversion of such Security and for all other purposes; and neither the Issuer, the Trustee, nor any agent of the Issuer or the Trustee shall be affected by any notice to the contrary. All such payments or
deliveries so made to any such Person, or upon his order, shall be valid, and, to the extent of the sums so paid or securities so delivered, effectual to satisfy and discharge the liability for sums payable or securities deliverable with respect to
any such Security. 
 Section 6.04. Securities Owned by Issuer Deemed Not Outstanding. In determining whether the Holders
of the requisite aggregate principal amount of Outstanding Securities of any or all series have concurred in any direction, consent or waiver under the Indenture, Securities which are owned by the Issuer or any other obligor on the Securities with
respect to which such determination is being made or by any Person directly or indirectly controlling or controlled by or under direct or indirect common control with the Issuer or any other obligor on the Securities with respect to which such
determination is being made shall be disregarded and deemed not to be Outstanding for the purpose of any such determination, except that for the purpose of determining whether the Trustee shall be protected in relying on any such direction, consent
or waiver only Securities which a Responsible Officer of the Trustee actually knows are so owned, or has received written notice that such Securities are so owned, shall be so disregarded. Securities so owned which have been pledged in good faith
may be regarded as Outstanding if the pledgee establishes to the satisfaction of the Trustee the pledgee’s right so to act with respect to such Securities and that the pledgee is not the Issuer or any other obligor upon the Securities or any
Person directly or indirectly controlling or controlled by or under direct or indirect common control with the Issuer or any other obligor on the Securities. In case of a dispute as to such right, the advice of counsel shall be full protection in
respect of any decision made by the Trustee in accordance with such advice. Upon request of the Trustee, the Issuer shall furnish to the Trustee promptly an Officer’s Certificate listing and identifying all Securities, if any, known by the
Issuer to be owned or held by or for the account of any of the above-described Persons; and, subject to Sections 5.01 and 5.05, the Trustee shall be entitled to accept such Officer’s Certificate as conclusive evidence of the facts therein set
forth and of the fact that all Securities not listed therein are Outstanding for the purpose of any such determination. 

  
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 Section 6.05. Right of Revocation of Action Taken. At any time prior to (but not
after) the evidencing to the Trustee, as provided in Section 6.01, of the taking of any action by the Holders of the percentage in aggregate principal amount of the Securities of any or all series, as the case may be, specified in the Indenture
in connection with such action, any Holder of a Security the serial number of which is shown by the evidence to be included among the serial numbers of the Securities the Holders of which have consented to such action may, by filing written notice
at the applicable Corporate Trust Office and upon proof of holding as provided in this Article, revoke such action so far as concerns such Security. Except as aforesaid any such action taken by the Holder of any Security shall be conclusive and
binding upon such Holder and upon all future Holders and owners of such Security and of any Securities issued in exchange or substitution therefor, irrespective of whether or not any notation in regard thereto is made upon any such Security. Any
action taken by the Holders of the percentage in aggregate principal amount of the Securities of any or all series, as the case may be, specified in the Indenture in connection with such action shall be conclusively binding upon the Issuer, the
Trustee and the Holders of all the Securities affected by such action. 
 ARTICLE 7 

AMENDMENTS, SUPPLEMENTS AND WAIVERS 

Section 7.01. Supplemental Indentures without Consent of Holders. The Issuer and the Trustee may amend the Indenture or the
Securities or enter into an indenture supplemental hereto without notice to or the consent of any Holder to 
 (a) establish the
form or forms of Securities of any series; 
 (b) provide for uncertificated Securities of any series in addition to or in place
of certificated Securities of the applicable series; 
 (c) provide for the assumption by a successor corporation, partnership,
trust or limited liability company of the Issuer’s obligations to the Holders of the Securities of any series, in each case in compliance with the applicable provisions of the Indenture; 

(d) to add to the covenants or Events of Default for the benefit of Holders of any series of Securities or surrender any right or power
conferred upon the Issuer under the Indenture; 
 (e) evidence and provide for the acceptance of appointment by a successor
Trustee; 
 (f) cure ambiguities, defects or inconsistencies; 

(g) secure the Securities of any series; 

  
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 (h) provide for or add guarantors with respect to the Securities of any series; 

(i) comply with any requirement of the Commission in connection with the qualification of the Indenture under the Trust Indenture Act;

 (j) increase the applicable conversion rate in the case of convertible Securities, provided such increase is in accordance
with the terms of the Indenture or will not adversely affect the interests of Holders of such Securities; 
 (k) conform any
provision in the Indenture or the terms of the Securities of any series to the prospectus, offering memorandum, offering circular or any other document pursuant to which the Securities of such series were offered, including any applicable supplement
thereto or term sheet setting forth the final terms of such Securities; 
 (l) supplement any provision of the Indenture to such
extent as shall be necessary to permit or facilitate the discharge of the Securities; provided that such change or modification does not adversely affect the interests of the Holders of the Securities; or 

(m) make any other change that would not reasonably be expected to adversely affect the rights of any Holder in any material respect.

 The Trustee is hereby authorized to join with the Issuer in the execution of any such amendment or supplemental indenture, to
make any further appropriate agreements and stipulations which may be therein contained and to accept the conveyance, transfer, assignment, mortgage or pledge of any property thereunder, but the Trustee shall not be obligated to enter into any such
amendment or supplemental indenture which affects the Trustee’s own rights, duties or immunities under the Indenture or otherwise. 
 Any amendment or supplemental indenture authorized by the provisions of this section may be executed without notice to and without the consent of the Holders of any of the Securities at the time
Outstanding, notwithstanding any of the provisions of Section 7.02. 
 Section 7.02. Supplemental Indentures with
Consent of Holders. (a) With the consent (evidenced as provided in Article 6) of the Holders of not less than a majority in aggregate principal amount of the Securities at the time Outstanding of all series affected by such amendment or
supplemental indenture (voting together as a single class), the Issuer, when authorized by a Resolution of its Board of Directors, and the Trustee may, from time to time and at any time, enter into an indenture or indentures supplemental hereto for
the purpose of adding any provisions to or changing in any manner or eliminating any of the provisions of the Indenture or of any supplemental indenture or of modifying in any manner the rights of the Holders of the Securities of each such series
and such Holders may waive future compliance by the Issuer with a provision of the Indenture or the Securities. 

  
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 (b) Notwithstanding the provisions of paragraph (a), without the consent of each affected
Holder of a particular series, an amendment, supplement or waiver may not 
 (i) reduce the rate of or extend
the stated time for payment of an installment of interest on any Securities; 
 (ii) reduce the principal amount
of or extend the stated maturity of any Securities; 
 (iii) amend or modify the redemption or required
repurchase provisions of any Securities in any manner adverse to the Holders of such Securities, whether through an amendment or waiver of such provisions in the covenants, definitions or otherwise, or reduce the price payable upon any such
redemption or repurchase; 
 (iv) if applicable, make any change that impairs or adversely affects the
conversion rights of any Securities; 
 (v) change the currency in which amounts on any Securities are payable;

 (vi) impair the right to institute suit for the enforcement of any payment on the Securities; 

(vii) reduce the quorum or voting requirements under the Indenture; 

(viii) adversely affect the ranking of the Securities of any series; 

(ix) make any change in the amendment provisions which require each Holder’s consent or in the waiver provisions of
the Indenture; or 
 (x) reduce the percentage in principal amount Outstanding of Securities of any series which
must consent to an amendment, supplement or waiver or consent to take any action. 
 It shall not be necessary for the consent
of the Holders under this section to approve the particular form of any proposed supplemental indenture, but it shall be sufficient if such consent shall approve the substance thereof. 

Section 7.03. Execution of Amendments or Supplemental Indentures or Waivers. Upon the request of the Issuer, accompanied by a copy
of a Resolution of the Board of Directors certified by the secretary or an assistant secretary of the Issuer authorizing the execution of any such amendment, supplemental indenture or waiver and upon the filing with the Trustee of evidence of the
consent of Holders as aforesaid and other documents, if any, required by Section 6.01, the Trustee shall join with the Issuer in the execution of such amendment, supplemental indenture or waiver unless such supplemental indenture or waiver
affects the Trustee’s own rights, duties or immunities under the Indenture or otherwise, in which case the Trustee may in its discretion, but shall not be obligated to, enter into such amendment, supplemental indenture or waiver. 

  
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 The Trustee, subject to the provisions of Sections 5.01 and 5.05, may receive an
Officer’s Certificate and an Opinion of Counsel as conclusive evidence that any amendment, supplemental indenture or waiver executed pursuant to this Article 7 complies with the applicable provisions of the Indenture and is authorized or
permitted by the Indenture; provided, however, that such Officer’s Certificate and Opinion of Counsel need not be provided in connection with the execution of an amendment, supplemental indenture or waiver that establishes the
terms of a series of Securities pursuant to Section 2.01 hereof. 
 Promptly after the execution by the Issuer and the
Trustee of any amendment, supplemental indenture or waiver pursuant to the provisions of this Section, the Issuer shall mail a notice thereof by first class mail to the Holders of each series affected thereby at their addresses as they shall appear
on the Register of the Issuer, setting forth in general terms the substance of such amendment, supplemental indenture or waiver. Any failure of the Issuer to mail such notice, or any defect therein, shall not, however, in any way impair or affect
the validity of any such amendment, supplemental indenture or waiver. 
 Section 7.04. Effect of Amendment, Supplemental
Indenture or Waiver. Upon the execution of any amendment, supplemental indenture or waiver pursuant to the provisions hereof, the Indenture shall be and be deemed to be modified and amended in accordance therewith and the respective rights,
limitations of rights, obligations, duties and immunities under the Indenture of the Trustee, the Issuer and the Holders of each series affected thereby shall thereafter be determined, exercised and enforced hereunder subject in all respects to such
modifications and amendments, and all the terms and conditions of any such amendment, supplemental indenture or waiver shall be and be deemed to be part of the terms and conditions of the Indenture for any and all purposes. 

Section 7.05. Effect of Consent. After an amendment, supplement or waiver becomes effective, it will bind every Holder unless it
is of the type requiring the consent of each Holder affected. If the amendment, supplement or waiver is of the type requiring the consent of each Holder affected, the amendment, supplement or waiver will bind each Holder that has consented to it and
every subsequent Holder of a Security that evidences the same debt as the Security of the consenting Holder. 
 Section 7.06.
Notation on Securities in Respect of Amendments, Supplemental Indentures or Waivers. Securities of any series authenticated and delivered after the execution of any amendment, supplemental indenture or waiver pursuant to the provisions of
this Article may bear a notation in form approved by the Trustee for such series, as to any matter provided for by such amendment, supplemental indenture or waiver or as to any action taken at any such meeting. If the Trustee shall so determine,

  
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new Securities of any series so modified as to conform, in the opinion of the Trustee and the Board of Directors of the Issuer, to any modification of the Indenture contained in any such
amendment, supplemental indenture or waiver may be prepared by the Issuer, authenticated by the Trustee and delivered in exchange for the Securities of such series then Outstanding. 

Section 7.07. Conformity with the Trust Indenture Act. Every amendment, supplemental indenture or waiver executed pursuant to this
Article shall conform to the requirements of the Trust Indenture Act as then in effect. 
 ARTICLE 8 

CONSOLIDATION, MERGER, SALE OR CONVEYANCE 

Section 8.01. Consolidation, Merger or Sale of Assets by the Issuer. The Issuer shall not merge or consolidate or combine with or
into or, directly or indirectly, sell, assign, convey, lease, transfer or otherwise dispose of all or substantially all of its assets to any Person or Persons in a single transaction or through a series of transactions, unless: 

(i) the Issuer shall be the continuing Person or, if the Issuer is not the continuing Person, the resulting, surviving or
transferee Person (the “Surviving Entity”) is (a) organized and existing under the laws of the United States or any state thereof or the District of Columbia or (b) organized under the laws of a jurisdiction outside the
United States and has a class of common stock (including ordinary shares or American depositary shares) traded on a national securities exchange in the United States; 

(ii) the Surviving Entity shall expressly assume all of the Issuer’s obligations under the Securities and the
Indenture, and shall, if required by law to effectuate the assumption, execute a supplemental indenture which will be delivered to the Trustee; 
 (iii) immediately after giving effect to such transaction or series of transactions on a pro forma basis, no Event of Default has occurred and is continuing; and 

(iv) the Issuer or the Surviving Entity will have delivered to the Trustee an Officer’s Certificate and Opinion of
Counsel stating that the transaction or series of transactions and a supplemental indenture, if any, complies with this Section 8.01 and that all conditions precedent in the Indenture relating to the transaction or series of transactions have
been satisfied. 
 Section 8.02. Successor Substituted. If any consolidation or merger or any sale, assignment,
conveyance, lease, transfer or other disposition of all or substantially all of the Issuer’s assets occurs in accordance with the Indenture, the successor Person shall 

  
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succeed to, and be substituted for, and may exercise every right and power of the Issuer under the Indenture with the same effect as if such successor Person had been named herein as the Issuer
and the Issuer shall (except in the case of a lease) be discharged from all obligations and covenants under the Indenture and the Securities. 
 ARTICLE 9 
 SATISFACTION AND
DISCHARGE; UNCLAIMED AMOUNTS 
 Section 9.01. Satisfaction and Discharge of
Indenture. The Issuer may terminate its obligations under the Indenture, when: 
 (a) either (i) all the Securities of
any series issued that have been authenticated and delivered have been accepted by the Trustee for cancellation (other than any Securities of such series which shall have been destroyed, lost or stolen and which shall have been replaced or paid as
provided in Section 2.09); or (ii) all the Securities of any series issued that have not been accepted by the Trustee for cancellation shall have become due and payable, or, except in the case of convertible Securities, are by their terms
to become due and payable within one year, and the (x) Issuer shall have made, except in the case of convertible Securities, irrevocable arrangements satisfactory to the Trustee for the giving of notice of redemption by such Trustee in the
Issuer’s name and at the Issuer’s expense and (y) the Issuer have irrevocably deposited or caused to be deposited with the Trustee cash (or the consideration, if applicable, to satisfy the Issuer’s conversion obligation with
respect to any convertible Securities) sufficient to pay (or convert, as applicable) all Securities of such series; and 
 (b)
The Issuer shall have paid or caused to be paid all other sums then due and payable under the Indenture; and 
 (c) The Issuer
shall have delivered to the Trustee an Officer’s Certificate and an Opinion of Counsel each stating that all conditions precedent under the Indenture relating to the satisfaction and discharge of the indenture have been complied with.

 If the foregoing conditions are met, the Trustee, on written demand of the Issuer accompanied by an Officer’s
Certificate and an Opinion of Counsel and at the cost and expense of the Issuer, shall execute proper instruments prepared by the Issuer acknowledging such satisfaction of and discharging the Indenture with respect to such series except as to:

 (1) rights of registration of transfer and exchange of Securities of such series, and the Issuer’s right of optional
redemption, if any; 
 (2) substitution of mutilated, defaced, destroyed, lost or stolen Securities; 

  
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 (3) rights of Holders to receive payments when due of principal thereof and interest thereon
(or the consideration due upon conversion), and remaining rights of the holders to receive mandatory sinking fund payments, if any; 
 (4) the rights, powers, trusts, duties and immunities of the Trustee hereunder; 

(5) the rights of the Holders of such series as beneficiaries hereof with respect to the property so deposited with the Trustee payable
to all or any of them; and 
 (6) the rights of the Issuer to be repaid any money pursuant to Sections 9.03 and 9.04.

 Section 9.02. Application by Trustee of Funds Deposited for Payment of Securities. Subject to Section 9.04, all
property deposited with the Trustee pursuant to Section 9.01 shall be held in trust and applied by it to the payment, either directly or through any paying agent (including the Issuer acting as its own paying agent), to the Holders of the
particular Securities of such series for the payment, conversion or redemption of which such property or, with respect to amounts payable in cash, Governmental Obligations have been deposited with the Trustee, of all sums due and to become due
thereon for principal and interest or for the consideration due upon conversion. Such property need not be segregated from other funds except to the extent required by law. 
 Section 9.03. Repayment of Property Held by Paying Agent. In connection with the satisfaction and discharge of the Indenture with respect to Securities of any series, all property then held by any
paying agent under the provisions of the Indenture with respect to such series of Securities shall, upon demand of the Issuer, be repaid or delivered to the Issuer or paid or delivered to the Trustee and thereupon such paying agent shall be released
from all further liability with respect to such property or Governmental Obligations. 
 Section 9.04. Return of Property
Held by Trustee and Paying Agent Unclaimed for Two Years. Any property and Governmental Obligations deposited with or paid or delivered to the Trustee or any paying agent for the payment of the principal of or interest on any Security of any
series (or for the consideration due upon conversion of such Security) and not applied but remaining unclaimed for two years after the date upon which such amounts shall have become due and payable, shall, upon the written request of the Issuer and
unless otherwise required by mandatory provisions of applicable escheat or abandoned or unclaimed property law, be repaid or delivered to the Issuer by the Trustee for such series or such paying agent, and the Holder of the Security of such series
shall, unless otherwise required by mandatory provisions of applicable escheat or abandoned or unclaimed property laws, thereafter look only to the Issuer for any payment or delivery of consideration which such Holder may be entitled to collect, and
all liability of the Trustee or any paying agent with respect to such property shall thereupon cease. 

  
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 ARTICLE 10 
 MISCELLANEOUS PROVISIONS 
 Section 10.01.
Incorporators, Stockholders, Employees, Officers and Directors of Issuer Exempt from Individual Liability. No recourse under or upon any obligation, covenant or agreement contained in the Indenture, or in any Security, or because of any
indebtedness evidenced thereby, shall be had against any incorporator, as such, or against any past, present or future stockholder, employee, officer or director, as such, of the Issuer or of any successor, either directly or through the Issuer or
any successor, under any rule of law, statute or constitutional provision or by the enforcement of any assessment or by any legal or equitable proceeding or otherwise, all such liability being expressly waived and released by the acceptance of the
Securities by the Holders thereof and as part of the consideration for the issue of the Securities. 
 Section 10.02.
Provisions of Indenture for the Sole Benefit of Parties and Holders. Nothing in the Indenture or in the Securities, expressed or implied, shall give or be construed to give to any Person, firm or corporation, other than the parties hereto and
their successors and the Holders of the Securities, any legal or equitable right, remedy or claim under the Indenture or under any covenant or provision herein contained, all such covenants and provisions being for the sole benefit of the parties
hereto and their successors and of the Holders of the Securities. 
 Section 10.03. Successors and Assigns of Issuer Bound by
Indenture. All the agreements of the Issuer in the Indenture and the Securities shall bind its successors and assigns. 

Section 10.04. Notices and Demands on Issuer, Trustee and Holders. Any notice or demand which by any provision of the Indenture is
required or permitted to be given or served by the Trustee or by the Holders to or on the Issuer may be given or served by being deposited postage prepaid, first-class mail (except as otherwise specifically provided herein) addressed (until another
address of the Issuer is filed by the Issuer with the Trustee) to Affymetrix, Inc., 3420 Central Expressway, Santa Clara, California 95051, Attention: Chief Financial Officer and a copy of such notice or demand shall be sent to the
Issuer’s General Counsel at the same address. Any notice, direction, request or demand by the Issuer or any Holder to or upon the Trustee shall be deemed to have been sufficiently given or made, for all purposes, if given or made at the
applicable Corporate Trust Office of the Trustee. 
 Where the Indenture provides for notice to Holders, such notice shall be
sufficiently given (unless otherwise herein expressly provided) if in writing and mailed, first-class postage prepaid, to each Holder entitled thereto, at his last address as it appears in the Register. In any case where notice to Holders is given
by mail, neither the failure to mail such notice, nor any defect in any notice so mailed, to any particular Holder shall affect the sufficiency of such notice with respect to other Holders. Where the Indenture provides for notice in any manner, such
notice may be waived in writing by the Person 

  
 47 

 
entitled to receive such notice, either before or after the event, and such waiver shall be the equivalent of such notice. Waivers of notice by Holders shall be filed with the Trustee, but such
filing shall not be a condition precedent to the validity of any action taken in reliance upon such waiver. 
 In case, by
reason of the suspension of or irregularities in regular mail service, it shall be impracticable to mail notice to the Issuer and Holders when such notice is required to be given pursuant to any provision of the Indenture, then any manner of giving
such notice as shall be satisfactory to the Trustee shall be deemed to be a sufficient giving of such notice. 
 In addition to
the foregoing, the Trustee agrees to accept and act upon notice, instructions or directions pursuant to the Indenture sent by unsecured e-mail, facsimile transmission or other similar unsecured electronic methods. If the party elects to give the
Trustee e-mail or facsimile instructions (or instructions by a similar electronic method) and the Trustee in its discretion elects to act upon such instructions, the Trustee’s understanding of such instructions shall be deemed controlling. The
Trustee shall not be liable for any losses, costs or expenses arising directly or indirectly from the Trustee’s reliance upon and compliance with such instructions notwithstanding such instructions conflict or are inconsistent with a subsequent
written instruction. The party providing electronic instructions agrees to assume all risks arising out of the use of such electronic methods to submit instructions and directions to the Trustee, including without limitation the risk of the Trustee
acting on unauthorized instructions, and the risk or interception and misuse by third parties. 
 Section 10.05.
Officer’s Certificates and Opinions of Counsel; Statements to Be Contained Therein. Upon any application or demand by the Issuer to the Trustee to take any action under any of the provisions of the Indenture, the Issuer shall furnish to
the Trustee an Officer’s Certificate stating that all conditions precedent, if any, provided for in the Indenture relating to the proposed action have been complied with and an Opinion of Counsel stating that in the opinion of such counsel all
such conditions precedent have been complied with, except that in the case of any such application or demand as to which the furnishing of such documents is specifically required by any provision of the Indenture relating to such particular
application or demand, no additional certificate or opinion need be furnished. 
 Each certificate or opinion provided for in
the Indenture and delivered to the Trustee with respect to compliance with a condition or covenant provided for in the Indenture shall include (a) a statement that the Person making such certificate or opinion has read such covenant or
condition, (b) a brief statement as to the nature and scope of the examination or investigation upon which the statements or opinions contained in such certificate or opinion are based, (c) a statement that, in the opinion of such Person,
he has made such examination or investigation as is necessary to enable him to express an informed opinion as to whether or not such covenant or condition has been complied with and (d) a statement as to whether or not, in the opinion of such
Person, such condition or covenant has been complied with. 

  
 48 

 Any certificate, statement or opinion of an officer of the Issuer may be based, insofar as
it relates to legal matters, upon a certificate or opinion of or representations by counsel, unless such officer knows that the certificate or opinion or representations with respect to the matters upon which his certificate, statement or opinion
may be based as aforesaid are erroneous, or in the exercise of reasonable care should know that the same are erroneous. Any certificate, statement or Opinion of Counsel may be based, insofar as it relates to factual matters, information with respect
to which is in the possession of the Issuer, upon the certificate, statement or opinion of or representations by an officer or officers of the Issuer, unless such counsel knows that the certificate, statement or opinion or representations with
respect to the matters upon which his certificate, statement or opinion may be based as aforesaid are erroneous, or in the exercise of reasonable care should know that the same are erroneous. 

Any certificate, statement or opinion of an officer of the Issuer or Opinion of Counsel may be based, insofar as it relates to accounting
matters, upon a certificate or opinion of or representations by an accountant or firm of accountants in the employ of the Issuer, unless such officer or counsel, as the case may be, knows that the certificate or opinion or representations with
respect to the accounting matters upon which his certificate, statement or opinion may be based as aforesaid are erroneous, or in the exercise of reasonable care should know that the same are erroneous. 

Any certificate or opinion of any independent firm of public accountants filed with the Trustee shall contain a statement that such firm
is independent. 
 Section 10.06. Payments Due on Saturdays, Sundays and Holidays. Except as provided pursuant to
Section 2.01 pursuant to a Resolution of the Board of Directors, and as set forth in an Officer’s Certificate, or established in one or more indentures supplemental to the Indenture, if the date of maturity of interest on or principal of
the Securities of any series, the date fixed for redemption or repayment of any such Security or the date of conversion of such Security shall not be a Business Day, then any action to be taken on such date need not be taken on such date, but may be
taken on the next succeeding Business Day with the same force and effect as if taken on such date, and no interest shall accrue in respect of the delay. 
 Section 10.07. Trust Indenture Act of 1939. The Indenture shall incorporate and be governed by the provisions of the Trust Indenture Act that are required to be part of and to govern indentures
qualified under the Trust Indenture Act. 
 If any provision hereof limits, qualifies or conflicts with a provision of the Trust
Indenture Act that is required hereunder to be a part of and govern this Indenture, the latter provision shall control. If any provision of the Indenture modifies or excludes any provision of the Trust Indenture Act that may be so modified or
excluded, the latter provision shall be deemed to apply to the Indenture as so modified or to be excluded, as the case may be. 

  
 49 

 Section 10.08. New York Law to Govern. The Indenture and each Security shall be
governed by and construed in accordance with the laws of the State of New York. 
 Section 10.09. Jurisdiction; Waiver Of
Jury Trial. The Issuer hereby irrevocably submits to the non-exclusive jurisdiction of any New York State court sitting in the Borough of Manhattan in the City of New York or any federal court sitting in the Borough of Manhattan in the City of
New York in respect of any suit, action or proceeding arising out of or relating to the Indenture and the Securities, and irrevocably accepts for itself and in respect of its property, generally and unconditionally, the non-exclusive jurisdiction of
the aforesaid courts. EACH OF THE ISSUER AND THE TRUSTEE HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF OR RELATING TO THE INDENTURE, THE
SECURITIES OR THE TRANSACTIONS CONTEMPLATED HEREBY. 
 Section 10.10. Counterparts. The Indenture may be executed in any
number of counterparts, each of which shall be an original, but such counterparts shall together constitute but one and the same instrument. 
 Section 10.11. Effect of Headings. The Article and Section headings herein and the Table of Contents are for convenience only and shall not affect the construction hereof. 

Section 10.12. Separability. In case any one or more of the provisions contained in the Indenture or in the Securities of any
series shall for any reason be held to be invalid, illegal, or unenforceable in any respect, such invalidity, illegality or unenforceability shall not affect or impair any other provisions of the Indenture or of such Securities, but the Indenture
and such Securities shall be construed as if such invalid or illegal or unenforceable provision had never been contained herein or therein. 
 ARTICLE 11 
 REDEMPTION OF
SECURITIES AND SINKING FUND PROVISIONS 
 Section
11.01. Applicability of Article. The provisions of this Article shall be applicable to the Securities of any series which are redeemable before their maturity or to any sinking fund for the retirement of Securities of a series except as
otherwise specified as contemplated by Section 2.03 for Securities of such series. 
 Section 11.02. Notice of
Redemption; Partial Redemptions. Notice of redemption to the Holders of any series to be redeemed as a whole or in part at the option 

  
 50 

 
of the Issuer shall be given by mailing notice of such redemption by first class mail, postage prepaid, at least 30 days and not more than 60 days prior to the date fixed for redemption to such
Holders of such series at their last addresses as they shall appear upon the Register. Any notice which is mailed in the manner herein provided shall be conclusively presumed to have been duly given, whether or not the Holder receives the notice.
Failure to give notice by mail, or any defect in the notice to the Holder of any Security of a series designated for redemption as a whole or in part shall not affect the validity of the proceedings for the redemption of any other Security of such
series. 
 The notice of redemption to each such Holder shall specify the principal amount of each Security of such series held
by such Holder to be redeemed, the date fixed for redemption (which must be a Business Day), the redemption price, the place or places of payment, the CUSIP and/or ISIN numbers, if any, that payment will be made upon presentation and surrender of
such Securities, that such redemption is pursuant to the mandatory or optional sinking fund, or both, if such be the case, that interest accrued to the date fixed for redemption will be paid as specified in such notice and that on and after said
date interest thereon or on the portions thereof to be redeemed will cease to accrue. Such notice shall also specify, in the case of convertible Securities, the procedures a Holder of such convertible Securities must follow to convert its
Securities, the period during which such Securities will be convertible prior to the applicable redemption date, the applicable conversion rate or price for such Securities and the settlement method to be used upon conversion (if the settlement
method is at the Issuer’s election). In case any Security of a series is to be redeemed in part only the notice of redemption shall state the portion of the principal amount thereof to be redeemed and shall state that on and after the date
fixed for redemption, upon surrender of such Security, a new Security or Securities of such series in principal amount equal to the unredeemed portion thereof will be issued. 
 The notice of redemption of Securities of any series to be redeemed shall be prepared and given by the Issuer or, at the Issuer’s request with 15 days’ notice to the Trustee (which notice period
may be shortened with the Trustee’s consent), prepared by the Issuer and given by the Trustee in the name and at the expense of the Issuer. 
 If less than all the Securities of a series are to be redeemed, the Securities to be redeemed shall be selected by lot or according to the Depositary’s applicable procedures in the case of Securities
represented by a Global Security, or, in the case of Securities not represented by a Global Security, the Trustee shall select, in such manner as it shall deem appropriate and fair, Securities of such series to be redeemed in whole or in part.
Securities may be redeemed in part in multiples equal to the minimum authorized denomination for Securities of such series or any multiple thereof. The Trustee shall promptly notify the Issuer in writing of the Securities of such series selected for
redemption and, in the case of any Securities of such series selected for partial redemption, the principal amount thereof to be redeemed. If any Security selected for partial redemption is submitted for conversion in part after such selection, the
portion of 

  
 51 

 
the Security submitted for conversion shall be deemed (so far as may be possible) to be the portion selected for redemption. For all purposes of the Indenture, unless the context otherwise
requires, all provisions relating to the redemption of Securities of any series shall relate, in the case of any Security redeemed or to be redeemed only in part, to the portion of the principal amount of such Security which has been or is to be
redeemed. 
 At least one Business Day prior to the redemption date specified in the notice of redemption given as provided in
this Section, the Issuer will deposit with the Trustee or with one or more paying agents (or, if the Issuer is acting as its own paying agent, set aside, segregate and hold in trust as provided in Section 3.03) an amount of money sufficient to
redeem on the redemption date all the Securities of such series so called for redemption at the appropriate redemption price, together with accrued interest to the date fixed for redemption. 

Section 11.03. Payment of Securities Called for Redemption. If notice of redemption has been given as above provided, the
Securities or portions of Securities specified in such notice shall become due and payable on the date and at the place stated in such notice at the applicable redemption price, together with interest accrued to the date fixed for redemption, and on
and after said date (unless the Issuer shall default in the payment of such Securities at the redemption price, together with interest accrued to said date) interest on the Securities or portions of Securities so called for redemption shall cease to
accrue and such Securities shall cease from and after the date fixed for redemption to be entitled to any benefit or security under the Indenture, and the Holders thereof shall have no right in respect of such Securities except the right to receive
the redemption price thereof and unpaid interest to the date fixed for redemption. On presentation and surrender of such Securities at a place of payment specified in said notice, said Securities or the specified portions thereof shall be paid and
redeemed by the Issuer at the applicable redemption price, together with interest accrued thereon to the date fixed for redemption; provided that any payment of interest becoming due on or before the date fixed for redemption shall be payable to the
Holders of such Securities registered as such on the relevant record date. 
 If any Security called for redemption shall not be
so paid upon surrender thereof for redemption, the principal shall, until paid or duly provided for, bear interest from the date fixed for redemption at the rate of interest or Yield to Maturity (in the case of an Original Issue Discount Security)
borne by the Security and, if applicable, such Security shall remain convertible until the applicable redemption price has been paid or duly provided for. 
 The Issuer may not redeem Securities of a series on any date if the principal amount of such Securities has been accelerated in accordance with the terms of the Indenture, and such acceleration has not
been rescinded, on or prior to the date fixed for redemption (except in the case of an acceleration resulting from a default by the Issuer in the payment of the applicable redemption price with respect to such Securities). 

  
 52 

 Upon presentation of any Security redeemed in part only, the Issuer shall execute and the
Trustee shall authenticate and deliver to or on the order of the Holder thereof, at the expense of the Issuer, a new Security or Securities of such series, of authorized denominations, in principal amount equal to the unredeemed portion of the
Security so presented. 
 Section 11.04. Exclusion of Certain Securities from Eligibility for Selection for Redemption.
Securities shall be excluded from eligibility for selection for redemption if they are identified by registration and certificate number in a written statement signed by an authorized officer of the Issuer and delivered to the Trustee at least 15
days prior to the last date on which notice of redemption may be given as being owned of record and beneficially by, and not pledged or hypothecated by either (a) the Issuer or (b) an entity specifically identified in such written
statement directly or indirectly controlling or controlled by or under direct or indirect common control with the Issuer. 

Section 11.05. Mandatory and Optional Sinking Funds. The minimum amount of any sinking fund payment provided for by the terms of
Securities of any series is herein referred to as a “mandatory sinking fund payment”, and any payment in excess of such minimum amount provided for by the terms of Securities of any series is herein referred to as an
“optional sinking fund payment”. The date on which a sinking fund payment is to be made is herein referred to as the “sinking fund payment date”. 

In lieu of making all or any part of any mandatory sinking fund payment with respect to any series of Securities in cash, the Issuer may
at its option (a) deliver to the Trustee Securities of such series theretofore purchased or otherwise acquired (except upon redemption pursuant to the mandatory sinking fund) by the Issuer or receive credit for Securities of such series (not
previously so credited) theretofore purchased or otherwise acquired (except as aforesaid) by the Issuer and delivered to the Trustee for cancellation pursuant to Section 2.10 and, if applicable, receive credit for convertible Securities (not
previously so credited) converted in accordance with their terms and so delivered to the Trustee for cancellation, (b) receive credit for optional sinking fund payments (not previously so credited) made pursuant to this Section, or
(c) receive credit for Securities of such series (not previously so credited) redeemed by the Issuer through any optional redemption provision contained in the terms of such series. Securities so delivered or credited shall be received or
credited by the Trustee at the sinking fund redemption price specified in such Securities. 
 Not less than 60 days prior to
each sinking fund payment date for any series, the Issuer will deliver to the Trustee a written statement (which need not contain the statements required by Section 10.05) signed by an authorized officer of the Issuer (a) specifying the
portion of the mandatory sinking fund payment to be satisfied by payment of cash and the portion to be satisfied by credit of Securities of such series, (b) stating that none of the Securities of such series has theretofore been so credited,
(c) stating that no defaults in the payment of interest or Events of Default with respect to such series have occurred (which have not been waived or cured) and are continuing and (d) stating

  
 53 

 
whether or not the Issuer intends to exercise its right to make an optional sinking fund payment with respect to such series and, if so, specifying the amount of such optional sinking fund
payment which the Issuer intends to pay on or before the next succeeding sinking fund payment date. Any Securities of such series to be credited and required to be delivered to the Trustee in order for the Issuer to be entitled to credit therefor as
aforesaid which have not theretofore been delivered to the Trustee shall be delivered for cancellation pursuant to Section 2.10 to the Trustee with such written statement (or reasonably promptly thereafter if acceptable to the Trustee). Such
written statement shall be irrevocable and upon its receipt by the Trustee the Issuer shall become unconditionally obligated to make all the cash payments or payments therein referred to, if any, on or before the next succeeding sinking fund payment
date. Failure of the Issuer, at least 60 days prior to such sinking fund payment date, to deliver such written statement and Securities specified in this paragraph, if any, shall not constitute a default but shall constitute, on and as of such date,
the irrevocable election of the Issuer (i) that the mandatory sinking fund payment for such series due on the next succeeding sinking fund payment date shall be paid entirely in cash without the option to deliver or credit Securities of such
series in respect thereof and (ii) that the Issuer will make no optional sinking fund payment with respect to such series as provided in this Section. 
 The Trustee shall select, in the manner provided in Section 11.02, for redemption on such sinking fund payment date a sufficient principal amount of Securities of such series to absorb said cash, as
nearly as may be, and shall (if requested in writing by the Issuer) inform the Issuer of the serial numbers of the Securities of such series (or portions thereof) so selected. Securities of any series which are (a) owned by the Issuer or an
entity known by the Trustee to be directly or indirectly controlling or controlled by or under direct or indirect common control with the Issuer, as shown by the Register, and not known to the Trustee to have been pledged or hypothecated by the
Issuer or any such entity or (b) identified in an Officer’s Certificate at least 60 days prior to the sinking fund payment date as being beneficially owned by, and not pledged or hypothecated by, the Issuer or an entity directly or
indirectly controlling or controlled by or under direct or indirect common control with the Issuer shall be excluded from Securities of such series eligible for selection for redemption. The notice of redemption of the Securities of such series to
be redeemed shall be prepared and given by the Issuer or, at the Issuer’s request, prepared by the Issuer and given by the Trustee in the name and at the expense of the Issuer in substantially the manner provided in Section 11.02 (and with
the effect provided in Section 11.03) for the redemption of Securities of such series in part at the option of the Issuer. The amount of any sinking fund payments not so applied or allocated to the redemption of Securities of such series shall
be added to the next cash sinking fund payment for such series and, together with such payment, shall be applied in accordance with the provisions of this Section. Any and all sinking fund amounts held on the stated maturity date of the Securities
of any particular series (or earlier, if such maturity is accelerated), which are not held for the payment or redemption of particular Securities of such series, shall be applied, together with other amounts, if necessary, sufficient for the
purpose, to the payment of the principal of, and interest on, the Securities of such series 

  
 54 

 
at maturity. The Issuer’s obligation to make a mandatory or optional sinking fund payment shall automatically be reduced by an amount equal to the sinking fund redemption price allocable to
any convertible Securities or portions thereof called for redemption pursuant to the preceding paragraph on any sinking fund payment date and converted in accordance with their terms; provided, that, if the Trustee is not the conversion agent for
the Securities, the Issuer or such conversion agent shall give the Trustee written notice prior to the date fixed for redemption of the principal amount of Securities or portions thereof so converted. 

At least one Business Day before each sinking fund payment date, the Issuer shall pay to the Trustee in cash or shall otherwise provide
for the payment of all interest accrued to the date fixed for redemption on Securities to be redeemed on the next following sinking fund payment date. 
 The Trustee shall not redeem or cause to be redeemed any Securities of a series with sinking fund amounts or mail any notice of redemption of Securities for such series by operation of the sinking fund
during the continuance of a default in payment of interest on such Securities or of any Event of Default except that, where the mailing of notice of redemption of any Securities shall theretofore have been made, the Trustee shall redeem or cause to
be redeemed such Securities, provided that it shall have received from the Issuer a sum sufficient for such redemption. Except as aforesaid, any amounts in the sinking fund for such series at the time when any such default or Event of Default shall
occur, and any amounts thereafter paid into the sinking fund, shall, during the continuance of such default or Event of Default, be deemed to have been collected under Article 4 and held for the payment of all such Securities. In case such Event of
Default shall have been waived as provided in Section 4.09 or the default cured on or before the 60th day preceding the sinking fund payment date in any year, such amounts shall thereafter be applied on the next succeeding sinking fund payment
date in accordance with this section to the redemption of such Securities. 
 [Signature Page Follows] 

  
 55 

 IN WITNESS WHEREOF, the parties hereto have caused the Indenture to be duly executed as of
the date set forth above. 
  

					
	AFFYMETRIX, INC., as Issuer
		
	By:	 	/s/ Timothy C. Barabe
		 	 Name:
	 	 Timothy C. Barabe

		 	 Title:
	 	Executive Vice President and Chief Financial Officer
	
	 THE BANK OF NEW YORK MELLON,
 TRUST COMPANY, N.A., as Trustee

		
	By:	 	/s/ Melonee Young
		 	Name:	 	Melonee Young
		 	 Title:
	 	 Vice PresidentFirst Supplemental Indenture

 Exhibit 4.2 

 
  

 
 AFFYMETRIX, INC. 

AND 
 THE BANK OF
NEW YORK MELLON TRUST COMPANY, N.A., 
 as Trustee 
 First Supplemental Indenture 
 Dated as of June 25, 2012 

to Indenture Dated as of 
 June 25, 2012 
 4.00% Convertible Senior Notes due 2019 

 
  

 

 TABLE OF CONTENTS 

 

					
		 	 	PAGE	  
	
	ARTICLE 1	  
	DEFINITIONS	  
		
	 Section 1.01. Definitions
	 	 	2	  
	 Section 1.02. References to Interest
	 	 	8	  
	
	ARTICLE 2	  
	ISSUE, DESCRIPTION, EXECUTION, REGISTRATION AND EXCHANGE
OF NOTES	  
		
	 Section 2.01. Scope of Supplemental Indenture
	 	 	8	  
	 Section 2.02. Designation and Amount
	 	 	8	  
	 Section 2.03. Form of Notes
	 	 	9	  
	 Section 2.04. Denominations Of Notes; Payments Of Interest
	 	 	9	  
	
	ARTICLE 3	  
	SATISFACTION AND DISCHARGE	  
		
	 Section 3.01. Satisfaction and Discharge of Indenture
	 	 	9	  
	
	ARTICLE 4	  
	AMENDMENTS, SUPPLEMENTS AND WAIVERS	  
		
	 Section 4.01. Supplemental Indentures With Consent Of Holders
	 	 	10	  
	
	ARTICLE 5	  
	PARTICULAR COVENANTS OF THE ISSUER	  
		
	 Section 5.01. Reports
	 	 	10	  
	
	ARTICLE 6	  
	DEFAULTS AND REMEDIES	  
		
	 Section 6.01. Events of Default
	 	 	10	  
	 Section 6.02. Additional Interest
	 	 	11	  
	
	ARTICLE 7	  
	CONSOLIDATION, MERGER, SALE, CONVEYANCE AND
LEASE	  
		
	 Section 7.01. Issuer May Consolidate, etc. on Certain Terms
	 	 	12	  

  
 i 

					
	
	ARTICLE 8	  
	CONVERSION OF NOTES	  
		
	 Section 8.01. Conversion Privilege
	 	 	12	  
	 Section 8.02. Conversion Procedure; Settlement Upon Conversion
	 	 	12	  
	 Section 8.03. Adjustment To Conversion Rate Upon Conversion Upon A Make-Whole Fundamental Change
	 	 	14	  
	 Section 8.04. Adjustment of Conversion Rate
	 	 	16	  
	 Section 8.05. Adjustments of Prices
	 	 	25	  
	 Section 8.06. Shares to be Fully Paid
	 	 	25	  
	 Section 8.07. Effect of Recapitalizations, Reclassifications and Changes of the shares of Common
Stock
	 	 	25	  
	 Section 8.08. Certain Covenants
	 	 	27	  
	 Section 8.09. Responsibility of Trustee
	 	 	27	  
	 Section 8.10. Notice to Holders Prior to Certain Actions
	 	 	28	  
	 Section 8.11. Shareholder Rights Plans
	 	 	28	  
	
	ARTICLE 9	  
	REPURCHASE OF NOTES AT OPTION OF
HOLDERS	  
		
	 Section 9.01. Repurchase at Option of Holders of the Notes Upon a Fundamental Change
	 	 	29	  
	 Section 9.02. Withdrawal of Fundamental Change Repurchase Notice
	 	 	31	  
	 Section 9.03. Deposit of Fundamental Change Repurchase Price
	 	 	32	  
	 Section 9.04. Covenant to Comply with Applicable Laws Upon Repurchase of Notes
	 	 	32	  
	
	ARTICLE 10	  
	OPTIONAL REDEMPTION	  
		
	 Section 10.01. Applicability of Article 11 of the Base Indenture
	 	 	33	  
	 Section 10.02. Optional Redemption on or Prior to November 30, 2012
	 	 	33	  
	 Section 10.03. Optional Redemption Upon Satisfaction Of Sale Price Condition
	 	 	33	  
	 Section 10.04. Conversion After Issuance Of A Redemption Notice
	 	 	34	  
	
	ARTICLE 11	  
	MISCELLANEOUS PROVISIONS	  
		
	 Section 11.01. Governing Law
	 	 	34	  
	 Section 11.02. No Security Interest Created
	 	 	34	  
	 Section 11.03. Benefits of Indenture
	 	 	34	  
	 Section 11.04. Effect of Headings
	 	 	34	  
	 Section 11.05. Supplemental Indenture May be Executed in Counterparts
	 	 	34	  
	 Section 11.06. Severability
	 	 	34	  
	 Section 11.07. Ratification of Base Indenture
	 	 	34	  
	 Section 11.08. Calculations
	 	 	35	  
	 Section 11.09. Trustee
	 	 	35	  

  
 ii 

 EXHIBIT 

 

							
	 Exhibit A
	 	Form of Note	  	 	A-1	  

  
 iii

 FIRST SUPPLEMENTAL INDENTURE dated as of June 25, 2012 (this “Supplemental
Indenture”) between Affymetrix, Inc., a Delaware corporation, as issuer (the “Issuer”, as more fully set forth in Section 1.01) and The Bank of New York Mellon Trust Company, N.A., as trustee (the
“Trustee”, as more fully set forth in Section 1.01), supplementing the Indenture relating to “Senior Debt Securities” dated as of June 25, 2012, between the Issuer and the Trustee (the “Base
Indenture” and, as amended and supplemented by this Supplemental Indenture, and as it may be further amended or supplemented from time to time with respect to the Notes, the “Indenture”). 

W I T N E S S E T H: 

WHEREAS, the Issuer executed and delivered the Base Indenture to the Trustee to provide, among other things, for the issuance, from time
to time, of the Issuer’s Securities, in an unlimited aggregate principal amount, in one or more series to be established by the Issuer under, and authenticated and delivered as provided in, the Base Indenture; 

WHEREAS, Sections 2.01 and 2.03 of the Base Indenture provide for the Issuer to issue Securities thereunder in the form and on the terms
set forth in one or more Board Resolutions or in one or more indentures supplemental thereto; 
 WHEREAS, for its lawful
corporate purposes, the Issuer has duly authorized the issuance of a single series of Securities designated as its 4.00% Convertible Senior Notes due 2019 (the “Notes”), initially in an aggregate principal amount initially not to
exceed $105,000,000 (as increased by an amount equal to the aggregate principal amount of any additional Notes purchased by the Underwriters pursuant to the exercise of their over-allotment option as set forth in the Underwriting Agreement), and in
order to provide the terms and conditions upon which the Notes are to be authenticated, issued and delivered, the Issuer has duly authorized the execution and delivery of this Supplemental Indenture; 

WHEREAS, the Form of Note, the Form of Notice of Conversion, the Form of Fundamental Change Repurchase Notice and the Form of Assignment
and Transfer to be borne by the Notes are to be substantially in the forms hereinafter provided; 
 WHEREAS, the conditions set
forth in the Base Indenture for the execution and delivery of this Supplemental Indenture have been complied with; and 

WHEREAS, all acts and things necessary to make the Notes, when executed by the Issuer and authenticated and delivered by the Trustee or a
duly authorized authenticating agent, as in this Supplemental Indenture provided, the valid, binding and legal obligations of the Issuer, and this Supplemental Indenture a valid agreement according to its terms, have been done and performed, and the
execution of this Supplemental Indenture and the issue hereunder of the Notes have in all respects been duly authorized. 
 NOW,
THEREFORE, THIS SUPPLEMENTAL INDENTURE WITNESSETH: 
 That in order to declare the terms and conditions upon which the Notes
are, and are to be, authenticated, issued and delivered, and in consideration of the premises and of the purchase and 

 
acceptance of the Notes by the Holders thereof, the Issuer covenants and agrees with the Trustee for the benefit of each other and for the equal and proportionate benefit of the respective
Holders from time to time of the Notes (except as otherwise provided below), as follows: 
 ARTICLE 1 

DEFINITIONS 
 Section 1.01. Definitions. For all purposes of the Indenture, except as otherwise expressly provided or unless the context otherwise requires: 

(a) the terms defined in this Article 1 shall have the respective meanings assigned to them in this Article 1 and include the plural as
well as the singular and, to the extent applicable, supersede the definitions thereof in the Base Indenture; 
 (b) all words,
terms and phrases defined in the Base Indenture (but not otherwise defined herein) shall have the same meanings as in the Base Indenture; and 
 (c) the words “herein,” “hereof” and “hereunder” and other words of similar import refer to the Indenture as a whole and not to any particular Article, Section or other
subdivision. 
 “Additional Interest” shall have the meaning specified in Section 6.02. 

“Additional Shares” shall have the meaning specified in Section 8.03(a). 

“Base Indenture” shall have the meaning specified in the first paragraph of this Supplemental Indenture. 

“Capital Stock” means, for any entity, any and all shares, interests, rights to purchase, warrants, options,
participations or other equivalents of or interests in (however designated) stock issued by that entity. 
 “Clause A
Distribution” shall have the meaning specified in Section 8.04(c). 
 “Clause B Distribution”
shall have the meaning specified in Section 8.04(c). 
 “Clause C Distribution” shall have the meaning
specified in Section 8.04(c). 
 “close of business” means 5:00 p.m. (New York City time). 

“Common Equity” of any Person means Capital Stock of such Person that is generally entitled (a) to vote in the
election of directors of such Person or (b) if such Person is not a corporation, to vote or otherwise participate in the selection of the governing body, partners, managers or others that will control the management or policies of such Person,
and in each case, not entitled to any preference in respect of dividends or amounts payable in the event of any voluntary or involuntary liquidation, dissolution or winding up of such Person. 

  
 2 

 “Common Stock” means the common stock of the Issuer, par value $0.01 per
share, at the date of this Supplemental Indenture, subject to Section 8.07. 
 “Conversion Date” shall
have the meaning specified in Section 8.02(c). 
 “Conversion Obligation” shall have the meaning specified
in Section 8.01. 
 “Conversion Price” means as of any date, $1,000, divided by the Conversion Rate
as of such date. 
 “Conversion Rate” shall have the meaning specified in Section 8.01. 

“Daily Conversion Value” means, for each of the 10 consecutive trading days during the applicable Observation Period,
10% of the product of (1) the Conversion Rate on such Trading Day and (2) the Daily VWAP on such Trading Day. 

“Daily VWAP” means, for each of the 10 consecutive Trading Days during the applicable Observation Period, the per share
volume-weighted average price as displayed under the heading “Bloomberg VWAP” on Bloomberg page “AFFX <equity> AQR” (or its equivalent successor if such page is not available) in respect of the period from the scheduled
open of trading until the scheduled close of trading of the primary trading session on such Trading Day (or if such volume-weighted average price is unavailable, the market value of one share of Common Stock on such Trading Day determined, using a
volume-weighted average method, by a nationally recognized independent investment banking firm retained for this purpose by the Issuer). The “Daily VWAP” shall be determined without regard to after hours trading or any other trading
outside of the regular trading session trading hours. 
 “Distributed Property” shall have the meaning
specified in Section 8.04(c). 
 “Effective Date” means (a) for purposes of Section 8.04, the
first date on which the shares of Common Stock trade on the applicable exchange or in the applicable market, regular way, reflecting the relevant share split or share combination, as applicable and (b) for any other purpose, as specified in
Section 8.03(c). 
 “Expiration Date” shall have the meaning specified in Section 8.04(e).

 “Expiration Time” shall have the meaning specified in Section 8.04(e). 

“Ex-Dividend Date” means the first date on which the shares of Common Stock trade on the applicable exchange or in the
applicable market, regular way, without the right to receive the issuance, dividend or distribution in question, from the Issuer or, if applicable, from the seller of shares of Common Stock on such exchange or market (in the form of due bills or
otherwise) as determined by such exchange or market. 
 “Form of Assignment and Transfer” shall mean the
“Form of Assignment and Transfer” attached as Attachment 3 to the Form of Note attached hereto as Exhibit A. 

  
 3 

 “Form of Fundamental Change Repurchase Notice” shall mean the “Form of
Fundamental Change Repurchase Notice” attached as Attachment 2 to the Form of Note attached hereto as Exhibit A. 

“Form of Notice of Conversion” shall mean the “Form of Notice of Conversion” attached as Attachment 1 to the
Form of Note attached hereto as Exhibit A. 
 A “Fundamental Change” shall be deemed to have occurred at the
time after the Notes are originally issued if any of the following occurs: 
 (1)(A) a “person” or
“group” within the meaning of Section 13(d) of the Exchange Act, other than the Issuer, a Subsidiary of the Issuer or the Issuer’s or a Subsidiary’s employee benefit plans, has become the direct or indirect “beneficial
owner,” as defined in Rule 13d-3 under the Exchange Act, of the Common Stock representing more than 50% of the voting power of the Common Stock and (B) a schedule, report or form is filed with the Commission disclosing such beneficial
ownership or the Issuer otherwise becomes aware of such beneficial ownership notwithstanding failure of such person or group to make any filing with the Commission; 

(2) the consummation of (A) any recapitalization, reclassification or change of the Common Stock (other than changes
resulting from a subdivision or combination) as a result of which the Common Stock would be converted into, or exchanged for, stock, other securities, other property or assets; (B) any share exchange, consolidation or merger of the Issuer
pursuant to which the Common Stock will be converted into cash, securities or other property; or (C) any sale, lease or other transfer in one transaction or a series of transactions of all or substantially all of the consolidated assets of the
Issuer and its Subsidiaries, taken as a whole, to any Person other than one of the Issuer’s Subsidiaries; provided, however, that neither (a) a transaction described in clause (B) in which the holders of all classes of the
Issuer’s Common Equity immediately prior to such transaction own, directly or indirectly, more than 50% of all classes of Common Equity of the continuing or surviving corporation or transferee or the parent thereof immediately after such
transaction in substantially the same proportions as such ownership immediately prior to such transaction nor (b) any merger primarily for the purpose of changing the Issuer’s jurisdiction of incorporation and resulting in a
reclassification, conversion or exchange of outstanding shares of the Common Stock solely into shares of Common Stock of the surviving entity shall be a Fundamental Change pursuant to this clause (2); 

(c) the stockholders of the Issuer approve any plan or proposal for the liquidation or dissolution of the Issuer; or

 (e) the Common Stock (or other common stock into which the Notes are then convertible) ceases to be listed or
quoted on The NASDAQ Global Select Market or another U.S. National Securities Exchange (as defined below). 
 Notwithstanding the foregoing, a
transaction as described in clause (1) or (2) above shall be deemed not to be a Fundamental Change (or a Make-Whole Fundamental Change) if at least 

  
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90% of the consideration received or to be received by the holders of the Common Stock, excluding cash payments for fractional shares and cash payments in respect of dissenters’ or appraisal
rights, in connection with such transaction or transactions otherwise constituting the Fundamental Change (or Make-Whole Fundamental Change) consists of shares of common stock that are traded on The NASDAQ Global Select Market or another U.S.
National Securities Exchange or which will be so traded or quoted when issued or exchanged in connection with such transaction or transactions (such securities, “Publicly Traded Securities”), and as a result of such transaction or
transactions the Notes become convertible into such Publicly Traded Securities, excluding cash payments for fractional shares and cash payments in respect of dissenters’ or appraisal rights (subject to the provisions of Section 8.02(a)).

 “Fundamental Change Issuer Notice” shall have the meaning specified in Section 9.01(b). 

“Fundamental Change Repurchase Date” shall have the meaning specified in Section 9.01(a). 

“Fundamental Change Repurchase Notice” shall have the meaning specified in Section 9.01(c)(i). 

“Fundamental Change Repurchase Price” shall have the meaning specified in Section 9.01(a). 

“Indenture” has the meaning specified in the first paragraph of this Supplemental Indenture. 

“Initial Conversion Value” means the product of (i) 170.0319 and (ii) $4.705. 

“Interest Payment Date” means each January 1 and July 1 of each year, beginning on January 1, 2013.

 “Issuer” shall have the meaning specified in the first paragraph of this Supplemental Indenture, and subject
to the provisions of Article 7, shall include its successors and assigns. 
 “Last Reported Sale Price” of the
Common Stock on any date means the closing sale price per share (or if no closing sale price is reported, the average of the bid and ask prices or, if more than one in either case, the average of the average bid and the average ask prices) on that
date as reported in composite transactions for the principal U.S. national or regional securities exchange on which the Common Stock is traded. If the Common Stock is not listed for trading on a U.S. national or regional securities exchange on the
relevant date, the “Last Reported Sale Price” shall be the last quoted bid price for the Common Stock in the over-the-counter market on the relevant date as reported by OTC Markets Group Inc. or a similar organization. If the Common
Stock is not so quoted, the “Last Reported Sale Price” shall be the average of the mid-point of the last bid and ask prices for the Common Stock on the relevant date from each of at least three nationally recognized independent
investment banking firms selected by the Issuer for this purpose. 

  
 5 

 “Make-Whole Fundamental Change” means any Fundamental Change described in
clause (1) or (2) of the definition thereof and determined after giving effect to any exceptions to or exclusions from such definition, but without regard to subclause (a) of the proviso in clause (2) of the definition
thereof. 
 “Market Disruption Event” means, for purposes of determining any Redemption Conversion Value,
(a) a failure by the primary U.S. national or regional securities exchange or market on which the Common Stock is listed or admitted for trading to open for trading during its regular trading session or (b) the occurrence or existence
prior to 1:00 p.m., New York City time, on any Scheduled Trading Day for the Common Stock for more than one half-hour period in the aggregate during regular trading hours of any suspension or limitation imposed on trading (by reason of movements in
price exceeding limits permitted by the relevant stock exchange or otherwise) in the Common Stock or in any options, contracts or future contracts relating to the Common Stock. 

“Maturity Date” means July 1, 2019. 
 “Merger Agreement” means the Amended and Restated Agreement and Plan of Merger dated as of May 3, 2012 by and among the Issuer, Excalibur Acquisition Sub, Inc., a Delaware
corporation and wholly owned subsidiary of the Issuer (“Excalibur”), eBioscience Holding Company, Inc., a Delaware corporation (“eBioscience”), and a representative of the securityholders of eBioscience. Subject to the conditions
set forth therein, Excalibur is to be merged with and into eBioscience (the “Merger”), with eBioscience surviving as a wholly-owned subsidiary of the Issuer. 
 “Merger Event” shall have the meaning specified in Section 8.07(a). 
 “Note” or “Notes” shall have the meaning specified in the third paragraph of the recitals of this Supplemental Indenture. 

“Notice of Conversion” shall have the meaning specified in Section 8.02(b). 

“Observation Period” for purposes of determining any Redemption Conversion Value for any optional redemption pursuant to
Section 10.02 means the 10 consecutive Trading Days beginning on, and including, the 12th Scheduled Trading Day immediately preceding the relevant redemption date. 
 “open of business” means 9:00 a.m. (New York City time). 

“Record Date” means, with respect to any dividend, distribution or other transaction or event in which the holders of
Common Stock (or other applicable security) have the right to receive any cash, securities or other property or in which the shares of Common Stock (or such other security) is exchanged for or converted into any combination of cash, securities or
other property, the date fixed for determination of holders of Common Stock (or such other security) entitled to receive such cash, securities or other property (whether such date is fixed by the Board of Directors, statute, contract or otherwise).

  
 6 

 “Redemption Conversion Value” means, with respect to any redemption date
pursuant to Section 10.02, the sum of the Daily Conversion Values for each Trading Day in the Observation Period. 

“Reference Property” shall have the meaning specified in Section 8.07(a). 

“Regular Record Date,” with respect to any Interest Payment Date, shall mean the December 15 or June 15
(whether or not such day is a Business Day) immediately preceding the applicable January 1 or July 1 Interest Payment Date, respectively. 
 “Scheduled Trading Day” means a day that is scheduled to be a Trading Day on the principal U.S. national or regional securities exchange or market on which the Common Stock is listed or
admitted for trading. If the Common Stock is not so listed or admitted for trading, “Scheduled Trading Day” means a Business Day. 
 “Spin-Off” shall have the meaning specified in Section 8.04(c). 
 “Stock Price” shall have the meaning specified in Section 8.03(c). 
 “Subsidiary” means a corporation more than 50% of the outstanding voting stock of which is owned, directly or indirectly, by the Issuer or by one or more other Subsidiaries, or by the
Issuer and one or more other Subsidiaries. For the purposes of this definition, “voting stock” means stock which ordinarily has voting power for the election of directors, whether at all times or only so long as no senior class of stock
has such voting power by reason of any contingency. 
 “Supplemental Indenture” has the meaning specified in
the first paragraph of this Supplemental Indenture. 
 “Trading Day” means (i) for purposes of determining
whether the Issuer may call the Notes for redemption pursuant to Section 10.03, a day on which (a) trading in the Common Stock (or other security for which a closing price must be determined) generally occurs on The NASDAQ Global Select
Market or, if the Common Stock (or such other security) is not then listed on The NASDAQ Global Select Market, on the principal other U.S. national or regional securities exchange on which the Common Stock is then listed or, if the Common Stock (or
such other security) is not then listed on a U.S. national or regional securities exchange, on the principal other market on which the Common Stock is then traded and (b) a Last Reported Sale Price for the Common Stock (or such other security)
is available on such securities exchange or market; provided that if the Common Stock (or such other security) is not so listed or traded, “Trading Day” means a Business Day and (ii) for purposes of determining any
Redemption Conversion Value, a day on which (x) there is no Market Disruption Event and (y) trading in the Common Stock generally occurs on The NASDAQ Global Select Market or, if the Common Stock is not then listed on The NASDAQ Global
Select Market, on the principal other U.S. national or regional securities exchange on which the Common Stock is then listed or, if the Common Stock is not then listed on a U.S. national or regional securities exchange, on the principal other market
on which the Common Stock is then listed or admitted for trading; provided that if the Common Stock is not listed or admitted for trading on any securities exchange or other market, “Trading Day” means a Business Day.

  
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 “Trigger Event” shall have the meaning specified in Section 8.04(c).

 “Trustee” means the Person named as the “Trustee” in the first paragraph of this
Supplemental Indenture until a successor Trustee shall have become such pursuant to the applicable provisions of the Indenture, and thereafter “Trustee” shall mean or include each Person who is then a Trustee hereunder. 

“Underwriters” means Citigroup Global Markets Inc., Morgan Stanley & Co. LLC. Merrill Lynch, Pierce,
Fenner & Smith Incorporated and Robert W. Baird & Co. Incorporated. 
 “Underwriting
Agreement” means that certain Underwriting Agreement, dated as of June 19, 2012, among the Issuer and the underwriters named therein. 
 “U.S. National Securities Exchange” means a securities exchange that has registered with the Commission. 
 “unit of Reference Property” shall have the meaning specified in Section 8.07(a). 
 “Valuation Period” shall have the meaning specified in Section 8.04(c). 
 Section 1.02. References to Interest. Unless the context otherwise requires, any reference to interest on, or in respect of, any Note in the Indenture shall be deemed to include Additional Interest
if, in such context, Additional Interest is, was or would be payable pursuant to Section 6.02. Unless the context otherwise requires, any express mention of Additional Interest in any provision hereof shall not be construed as excluding
Additional Interest in those provisions hereof where such express mention is not made. 
 ARTICLE 2 

ISSUE, DESCRIPTION, EXECUTION, REGISTRATION AND
EXCHANGE OF NOTES 
 Section 2.01. Scope of Supplemental Indenture. This
Supplemental Indenture supplements the provisions of the Base Indenture, to which provisions reference is hereby made. The changes, modifications and supplements to the Base Indenture effected by this Supplemental Indenture shall be applicable only
with respect to, and shall only govern the terms of, the Notes, which may be issued from time to time, and shall not apply to any other Securities that may be issued under the Base Indenture unless a supplemental indenture with respect to such other
Securities specifically incorporates such changes, modifications and supplements. For all purposes under the Base Indenture, the Notes shall constitute a single series of Securities. The provisions of this Supplemental Indenture shall supersede any
conflicting provisions in the Base Indenture.  
 Section 2.02. Designation and Amount. The Notes are hereby
created and authorized as a single series of Securities under the Base Indenture. The Notes shall be designated as the “4.00% Convertible Senior Notes due 2019.” The aggregate principal amount of Notes that may be authenticated and
delivered under the Indenture is initially limited to $105,000,000 (as increased by an amount equal to the aggregate principal amount of any additional Notes 

  
 8 

 
purchased by the Underwriters pursuant to the exercise of their over-allotment option as set forth in the Underwriting Agreement), subject to Section 2.03 of the Base Indenture and except
for Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of other Notes pursuant to Section 2.08, Section 2.09, Section 2.11 and Section 2.13 of the Base Indenture and
Section 8.02 and Section 9.03 of this Supplemental Indenture. With respect to the Notes, the reference in Section 7.01 of the Base Indenture to the “prospectus, offering memorandum, offering circular or any other document
pursuant to which the Securities of such series were offered” is to the prospectus dated June 14, 2012, as supplemented by the preliminary prospectus supplement thereto, dated June 18, 2012 and the related issuer free writing
prospectus (as such term is defined in Rule 433 under the Securities Act) dated June 19, 2012, each as filed with the Commission. 
 Section 2.03. Form of Notes. The Notes shall be substantially in the form set forth in Exhibit A, the terms and provisions of which shall constitute, and are hereby expressly incorporated in and
made a part of the Indenture. The Notes will initially be issued as a Global Security. To the extent applicable, the Issuer and the Trustee, by their execution and delivery of the Indenture, expressly agree to such terms and provisions and to be
bound thereby. 
 Section 2.04. Denominations Of Notes; Payments Of Interest. The Notes shall be issuable in registered
form without coupons in denominations of $1,000 principal amount and integral multiples thereof. Each Note shall be dated the date of its authentication and shall bear interest from the date specified on the face of the form of Note attached as
Exhibit A hereto. Accrued interest on the Notes shall be computed on the basis of a 360-day year composed of twelve 30-day months and, for partial months, on the basis of actual days elapsed over a 30-day month. 

ARTICLE 3 

SATISFACTION AND DISCHARGE 

Section 3.01. Satisfaction and Discharge of Indenture. Section 9.01(a) of the Base Indenture is amended and restated in its
entirety as follows with respect to the Notes: “either (i) all Notes theretofore authenticated and delivered (other than (x) Notes which have been destroyed, lost or stolen and which have been replaced or paid as provided in
Section 2.09 of the Base Indenture and (y) Notes for which payment money has theretofore been deposited in trust or segregated and held in trust by the Issuer and thereafter repaid to the Issuer as provided in Section 9.04 of the Base
Indenture) have been delivered to the Trustee (or, if different, the Registrar), for cancellation; or (ii) the Issuer has deposited with the Trustee or delivered to Holders, as applicable, after the Notes have become due and payable, whether at
the Maturity Date, any redemption date, at any Fundamental Change Repurchase Date, upon conversion or otherwise, cash or, solely to satisfy the Issuer’s Conversion Obligation, cash and shares of Common Stock, as applicable, sufficient to pay
all of the Outstanding Notes and/or satisfy all outstanding conversions, as the case may be.” 

  
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 ARTICLE 4 
 AMENDMENTS, SUPPLEMENTS AND WAIVERS 
 Section 4.01. Supplemental Indentures With Consent Of Holders. Section 7.02(a) of the Base Indenture is hereby amended with respect to the Notes by replacing “not less than a majority in
aggregate principal amount of the Securities at the time Outstanding of all series affected by such amendment or supplemental indenture (voting together as a single class)” with “not less than a majority in aggregate principal amount of
the Notes.” 
 ARTICLE 5 
 PARTICULAR COVENANTS OF THE ISSUER 
 Section 5.01. Reports. This Section 5.01 shall supersede Section 3.05 of the Base Indenture and all references in the Base Indenture to Section 3.05 thereof shall be deemed, for the
purposes of the Notes, to be references to this Section 5.01. The Issuer shall file with the Trustee within 30 calendar days after the same are required to be filed with the Commission, copies of any documents or reports that the Issuer is
required to file with the Commission pursuant to Section 13 or 15(d) of the Exchange Act (giving effect to any grace period provided by Rule 12b-25 under the Exchange Act). Any such document or report that the Issuer files with the Commission
via the Commission’s EDGAR system shall be deemed to be furnished to the Trustee for purposes of this Section 5.01 at the time such documents are filed via the EDGAR system. The Trustee shall have no obligation to determine whether or not
such information, documents or reports have been filed through the EDGAR filing system (or such successor thereto). Delivery of the reports and documents described in this Section 5.01 to the Trustee is for informational purposes only, and the
Trustee’s receipt of the same shall not constitute constructive notice of any information contained therein or determinable from information contained therein, including the Issuer’s compliance with any of its covenants under the Indenture
(as to which the Trustee is entitled to rely exclusively on an Officer’s Certificate). 
 ARTICLE 6 

DEFAULTS AND REMEDIES 

Section 6.01. Events of Default. In addition to the Events of Default set forth in Section 4.01 of the Base Indenture, each
of the following is an “Event of Default” with respect to the Notes: 
 (a) failure by the Issuer to convert
the Notes in accordance with Article 8 hereof and such default continues for a period of ten calendar days; 
 (b) failure by
the Issuer to provide a Fundamental Change Issuer Notice after the occurrence of a Fundamental Change within the time period required by Section 9.01(b); or 
 (c) default by the Issuer or any Subsidiary under any loan agreement or other instrument under which there may be outstanding, or by which there may be evidenced, any debt for money borrowed in excess of
$30.0 million in the aggregate of the Issuer and its Subsidiaries 

  
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(other than indebtedness for borrowed money secured only by the real property to which the indebtedness relates and which is non-recourse to the Issuer or to such Subsidiary), whether such debt
now exists or shall hereafter be created, (x) resulting in such debt becoming or being declared due and payable prior to its stated maturity or (y) resulting from the failure of the Issuer or any of its Subsidiaries to pay amounts due and
payable upon its stated maturity, required repurchase or redemption, and such acceleration shall not have been rescinded or annulled or such failure to pay cured within 60 days after written notice has been received by the Issuer or such Subsidiary
from the Trustee or by the Trustee, the Issuer and such Subsidiary by the Holders of at least 25% in principal amount of Outstanding Notes specifying such default and requiring it to be remedied; provided that if any time before a judgment or
decree has been obtained by the Trustee as hereinafter provided, such default is remedied or cured by the Issuer within the applicable cure period, or is waived or rescinded by the holders of such indebtedness or is otherwise annulled, default under
this clause (c) shall be deemed to have been remedied, cured, waived, rescinded or annulled, as the case may be. 
 In
addition, Section 4.01(d) of the Base Indenture is hereby amended with respect to the Notes by replacing “90 days” with “60 days.” 
 Section 6.02. Additional Interest. Notwithstanding Section 4.01 of the Base Indenture, to the extent elected by the Issuer, the sole remedy for an Event of Default relating to (i) the
failure by the Issuer to file with the Trustee pursuant to Section 314(a)(1) of the Trust Indenture Act any documents or reports that the Issuer is required to file with the Commission pursuant to Section 13 or 15(d) of the Exchange Act or
(ii) the failure to comply with the reporting obligations under Section 5.01 hereof, shall for the first 180 calendar days after the occurrence of such an Event of Default consist exclusively of the right to receive additional interest
(“Additional Interest”) on the Notes at a rate equal to (x) 0.25% per annum of the principal amount of the Notes Outstanding for each day during the first 90 calendar days of such 180 calendar day period on which such
Event of Default is continuing and (y) 0.50% per annum of the principal amount of the Notes Outstanding for the remaining 90 calendar days of such 180 calendar day period on which such Event of Default is continuing. 

If the Issuer so elects to pay additional interest, any such Additional Interest shall be payable in the same manner
and on the same dates as the stated interest payable on the Notes. On the 181st calendar day after such Event of Default (if the Event of Default relating to the reporting obligations is not cured or waived prior to such 181st calendar day), the Notes shall be subject to acceleration under Section 4.01 of the Base Indenture. The
provisions of this Section 6.02 shall not affect the rights of Holders of the Notes in the event of the occurrence of any other Event of Default. In the event the Issuer does not elect to pay the Additional Interest following an Event of
Default in accordance with this Section 6.02 or the Issuer elected to make such payment but does not pay the Additional Interest when due, the Notes shall be immediately subject to acceleration under Section 4.01 of the Base Indenture.

 In order to elect to pay the Additional Interest as the sole remedy during the first 180 calendar days after the occurrence
of an Event of Default relating to the failure to comply with its reporting obligations under Section 314(a)(1) of the TIA or under Section 5.01, in accordance with this Section 6.02, the Issuer must notify all Holders of the Notes,
the Trustee and the paying agent of such election prior to the beginning of such 180-day period. Upon the Issuer’s failure to 

  
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timely give such notice, the Notes shall be immediately subject to acceleration under Section 4.01 of the Base Indenture. Unless and until a Responsible Officer of the Trustee receives at
the Corporate Trust Office such a certificate, the Trustee may assume without inquiry that no such Additional Interest is payable. 
 ARTICLE 7 
 CONSOLIDATION, MERGER,
SALE, CONVEYANCE AND LEASE 
 Section 7.01. Issuer May
Consolidate, etc. on Certain Terms. Section 8.01(i) of the Base Indenture is hereby amended and restated in its entirety as follows: “The Issuer shall be the continuing Person or, if the Issuer is not the continuing Person, the
resulting, surviving or transferee Person (the “Surviving Entity”) is organized and existing under the laws of the United States or any state thereof or the District of Columbia.” 

ARTICLE 8 

CONVERSION OF NOTES 
 Section 8.01. Conversion Privilege. Subject to and upon compliance with the provisions of this Article 8 and Section 10.04, each Holder of a Note shall have the right, at such Holder’s
option, to convert all or any portion (if the portion to be converted is $1,000 principal amount or an integral multiple thereof) of such Note at any time prior to the close of business on the Business Day immediately preceding the Maturity Date at
an initial conversion rate of 170.0319 shares of Common Stock (subject to adjustment as provided in this Article 8, the “Conversion Rate”) per $1,000 principal amount of Notes (subject to the settlement provisions of Section 8.02,
the “Conversion Obligation”). 
 Section 8.02. Conversion Procedure; Settlement Upon Conversion.

 (a) Upon conversion of any Note, the Issuer shall deliver to the converting Holder, in respect of each $1,000 principal
amount of Notes being converted, a number of shares of Common Stock equal to the Conversion Rate, together with a cash payment, if applicable, in lieu of any fractional share of Common Stock in accordance with subsection (j) of this
Section 8.02, on the third Business Day immediately following the relevant Conversion Date. 
 (b) Subject to
Section 8.02(e), before any Holder of a Note shall be entitled to convert a Note as set forth above, such Holder shall (i) in the case of a Global Security, comply with the procedures of the Depositary in effect at that time and, if
required, pay funds equal to interest payable on the next Interest Payment Date to which such Holder is not entitled as set forth in Section 8.02(h) and (ii) in the case of a certificated Note (1) complete, manually sign and deliver an
irrevocable notice to the conversion agent as set forth in the Form of Notice of Conversion (or a facsimile thereof) (a “Notice of Conversion”) at the office of the conversion agent and state in writing therein the principal amount
of Notes to be converted and the name or names (with addresses) in which such Holder wishes the certificate or certificates for any shares of Common Stock to be delivered upon settlement of the Conversion Obligation to be registered,

  
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(2) surrender such Notes, duly endorsed to the Issuer or in blank (and accompanied by appropriate endorsement and transfer documents), at the office of the conversion agent, (3) if
required, furnish appropriate endorsements and transfer documents and (4) if required, pay funds equal to interest payable on the next Interest Payment Date to which such Holder is not entitled as set forth in Section 8.02(h). The Trustee (and
if different, the conversion agent) shall notify the Issuer of any conversion pursuant to this Article 8 on the Conversion Date for such conversion. No Notice of Conversion with respect to any Notes may be surrendered by a Holder thereof if
such Holder has also delivered a Fundamental Change Repurchase Notice to the Issuer in respect of such Notes and not validly withdrawn such Fundamental Change Repurchase Notice in accordance with Section 9.02. 

If more than one Note shall be surrendered for conversion at one time by the same Holder, the Conversion Obligation with respect to such
Notes shall be computed on the basis of the aggregate principal amount of the Notes (or specified portions thereof to the extent permitted thereby) so surrendered. 
 (c) A Note shall be deemed to have been converted immediately prior to the close of business on the date (the “Conversion Date”) that the Holder has complied with the requirements set
forth in subsection (b) above. The Issuer shall issue or cause to be issued, and deliver to the conversion agent or to such Holder, or such Holder’s nominee or nominees, certificates or a book-entry transfer through the Depositary for the full
number of shares of Common Stock to which such Holder shall be entitled in satisfaction of the Issuer’s Conversion Obligation. 
 (d) In case any Note shall be surrendered for partial conversion, the Issuer shall execute and the Trustee shall authenticate and deliver to or upon the written order of the Holder of the Note so
surrendered a new Note or Notes in authorized denominations in an aggregate principal amount equal to the unconverted portion of the surrendered Note, without payment of any service charge by the converting Holder but, if required by the Issuer or
Trustee, the converting Holder shall pay a sum sufficient to cover any transfer tax or similar governmental charge required by law or that may be imposed in connection therewith as a result of the name of the Holder of the new Notes issued upon such
conversion being different from the name of the Holder of the old Notes surrendered for such conversion. 
 (e) If a Holder
submits a Note for conversion, the Issuer shall pay any documentary, stamp or similar issue or transfer tax due on the issue of the shares of Common Stock upon conversion, unless the tax is due because the Holder requests such shares to be issued in
a name other than the Holder’s name, in which case the Holder shall pay that tax. The conversion agent may refuse to deliver the certificates representing the shares of Common Stock being issued in a name other than the Holder’s name until
the Trustee receives a sum sufficient to pay any tax that is due by such Holder in accordance with the immediately preceding sentence. 
 (f) Except as provided in Section 8.04, no adjustment shall be made for dividends on any shares issued upon the conversion of any Note as provided in this Article 8. 

(g) Upon the conversion of an interest in a Global Security, the Trustee, or the Custodian at the direction of the Trustee, shall make a
notation on such Global Security as to the reduction in the principal amount represented thereby. The Issuer shall notify the Trustee in writing of any conversion of Notes effected through any conversion agent other than the Trustee. 

  
 13 

 (h) Upon conversion, a Holder shall not receive any separate cash payment for accrued and
unpaid interest, if any, except as set forth below. The Issuer’s settlement of the Conversion Obligation shall be deemed to satisfy in full its obligation to pay the principal amount of the Note and accrued and unpaid interest, if any, to, but
not including, the relevant Conversion Date. As a result, accrued and unpaid interest, if any, to, but not including, the relevant Conversion Date shall be deemed to be paid in full rather than cancelled, extinguished or forfeited. Notwithstanding
the foregoing, if Notes are converted after the close of business on a Regular Record Date, Holders of such Notes as of the close of business on such Regular Record Date will receive the full amount of interest payable on such Notes on the
corresponding Interest Payment Date notwithstanding the conversion. Notes surrendered for conversion during the period from the close of business on any Regular Record Date to the open of business on the immediately following Interest Payment Date
must be accompanied by funds equal to the amount of interest payable on the Notes so converted on such Interest Payment Date; provided that no such payment shall be required (1) for conversions following the Regular Record Date
immediately preceding the Maturity Date; (2) if the Issuer has specified a Fundamental Change Repurchase Date that is after a Regular Record Date and on or prior to the corresponding Interest Payment Date; (3) if the Issuer has specified a
redemption date for the Notes that is after a Regular Record Date and on or prior to the corresponding Interest Payment Date; or (4) to the extent of any overdue amounts, if any overdue amounts exist at the time of conversion with respect to
such Note. 
 (i) The Person in whose name the certificate for any shares of Common Stock delivered upon conversion is
registered shall be treated as a stockholder of record as of the close of business on the relevant Conversion Date. Upon a conversion of Notes, such Person shall no longer be a Holder of such Notes surrendered for conversion. 

(j) The Issuer shall not issue any fractional share of Common Stock upon conversion of the Notes and shall instead pay cash in lieu of
any fractional share of Common Stock issuable upon conversion based on the Last Reported Sale Price of the Common Stock on the relevant Conversion Date. 
 Section 8.03. Adjustment To Conversion Rate Upon Conversion Upon A Make-Whole Fundamental Change. (a) If the Effective Date of a Make-Whole Fundamental Change occurs prior to the Maturity Date and
a Holder of the Notes elects to convert its Notes in connection with such Make-Whole Fundamental Change, the Issuer shall, under the circumstances described below, increase the Conversion Rate for the Notes so surrendered for conversion by a number
of additional shares of Common Stock (the “Additional Shares”), as described below. A conversion of Notes shall be deemed for these purposes to be “in connection with” such Make-Whole Fundamental Change if the relevant
Notice of Conversion is received by the conversion agent at any time during the period from, and including, the Effective Date of the Make-Whole Fundamental Change up to, and including, the Business Day immediately prior to the related Fundamental
Change Repurchase Date (or, in the case of a Make-Whole Fundamental Change that would have been a Fundamental Change but for subclause (a) of the proviso in clause 2 of the definition thereof, the 35th Trading Day immediately following
the Effective Date of such Make-Whole Fundamental Change). 

  
 14 

 (b) Upon surrender of Notes for conversion in connection with a Make-Whole Fundamental
Change, the Issuer shall deliver shares of Common Stock, including the Additional Shares, in accordance with Section 8.02; provided, however, that if, at the effective time of a Make-Whole Fundamental Change described in clause
(2) of the definition of Fundamental Change, the Reference Property following such Make-Whole Fundamental Change is composed entirely of cash, for any conversion of Notes following the Effective Date of such Make-Whole Fundamental Change, the
Conversion Obligation shall be calculated based solely on the Stock Price for the transaction and shall be deemed to be an amount of cash per $1,000 principal amount of converted Notes equal to the Conversion Rate (including any adjustment for
Additional Shares), multiplied by such Stock Price. The Issuer shall notify the Holders of Notes and the Trustee of the Effective Date of any Make-Whole Fundamental Change and issue a press release announcing such Effective Date no later than five
Business Days after such Effective Date. 
 (c) The number of Additional Shares, if any, by which the Conversion Rate shall be
increased for conversions in connection with a Make-Whole Fundamental Change shall be determined by reference to the table below, based on the date on which the Make-Whole Fundamental Change occurs or becomes effective (the “Effective
Date”) and the price (the “Stock Price”) paid (or deemed to be paid) per share of Common Stock in the Make-Whole Fundamental Change. If the holders of Common Stock receive in exchange for their Common Stock only cash in a
Make-Whole Fundamental Change described in clause 2 of the definition of Fundamental Change, the Stock Price shall be the cash amount paid per share. Otherwise, the Stock Price shall be the average of the Last Reported Sale Prices of the Common
Stock over the five Trading Day period ending on, and including, the Trading Day immediately preceding the Effective Date of the Make-Whole Fundamental Change. 
 (d) The Stock Prices set forth in the column headings of the table below shall be adjusted as of any date on which the Conversion Rate of the Notes is otherwise adjusted. The adjusted Stock Prices shall
equal the Stock Prices applicable immediately prior to such adjustment, multiplied by a fraction, the numerator of which is the Conversion Rate immediately prior to such adjustment giving rise to the Stock Price adjustment and the denominator
of which is the Conversion Rate as so adjusted. The number of Additional Shares set forth in the table below shall be adjusted in the same manner and at the same time as the Conversion Rate as set forth in Section 8.04. 

(e) The following table sets forth the hypothetical Stock Price and the number of Additional Shares to be added to the Conversion Rate
per $1,000 principal amount of Notes pursuant to this Section 8.03: 

  
 15 

																																																	
	  	  	Stock Price	 
	Effective Date	  	$4.705	 	  	$5.00	 	  	$6.00	 	  	$7.00	 	  	$7.65	 	  	$8.00	 	  	$9.00	 	  	$10.00	 	  	$11.00	 	  	$12.00	 	  	$13.00	 	  	$15.00	 
	 June 25, 2012
	  	 	42.5080	  	  	 	39.2047	  	  	 	27.5210	  	  	 	21.3477	  	  	 	18.8288	  	  	 	17.7386	  	  	 	15.2942	  	  	 	13.4865	  	  	 	12.0648	  	  	 	10.8836	  	  	 	9.8838	  	  	 	8.2853	  
	 July 1, 2013
	  	 	42.5080	  	  	 	37.3809	  	  	 	24.9443	  	  	 	18.5893	  	  	 	16.1579	  	  	 	15.1511	  	  	 	12.9723	  	  	 	11.4189	  	  	 	10.2163	  	  	 	9.2231	  	  	 	8.3829	  	  	 	7.0389	  
	 July 1, 2014
	  	 	42.5080	  	  	 	36.7523	  	  	 	23.0701	  	  	 	16.0794	  	  	 	13.4882	  	  	 	12.4976	  	  	 	10.4515	  	  	 	9.0794	  	  	 	8.0885	  	  	 	7.3060	  	  	 	6.6453	  	  	 	5.5885	  
	 July 1, 2015
	  	 	42.5080	  	  	 	34.4273	  	  	 	19.7098	  	  	 	12.4760	  	  	 	9.9926	  	  	 	9.1001	  	  	 	7.4166	  	  	 	6.3982	  	  	 	5.7079	  	  	 	5.1605	  	  	 	4.6972	  	  	 	3.9561	  
	 July 1, 2016
	  	 	42.5080	  	  	 	33.2123	  	  	 	16.5990	  	  	 	8.7267	  	  	 	6.2488	  	  	 	5.4177	  	  	 	4.0703	  	  	 	3.4269	  	  	 	3.0568	  	  	 	2.7656	  	  	 	2.5193	  	  	 	2.1250	  
	 July 1, 2017
	  	 	42.5080	  	  	 	33.0715	  	  	 	12.6140	  	  	 	2.8041	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  
	 July 1, 2018
	  	 	42.5080	  	  	 	35.4387	  	  	 	14.1245	  	  	 	2.6464	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  
	 July 1, 2019
	  	 	42.5080	  	  	 	29.9681	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  

 The exact Stock Prices and Effective Dates may not be set forth in the table above, in which case:

 (i) if the Stock Price is between two Stock Prices in the table above or the Effective Date is between two
Effective Dates in the table, the number of Additional Shares shall be determined by a straight-line interpolation between the number of Additional Shares set forth for the higher and lower Stock Prices and the earlier and later Effective Dates
based on a 365-day year, as applicable; 
 (ii) if the Stock Price is greater than $15.00 per share (subject to
adjustment in the same manner as the Stock Prices set forth in the column headings of the table above pursuant to subsection (d) above), no Additional Shares shall be added to the Conversion Rate; and 

(iii) if the Stock Price is less than $4.705 per share (subject to adjustment in the same manner as the Stock Prices set
forth in the column headings of the table above pursuant to subsection (d) above), no Additional Shares shall be added to the Conversion Rate. 
 Notwithstanding the foregoing, in no event shall the Conversion Rate per $1,000 principal amount of Notes exceed 212.5399, subject to adjustment in the same manner as the Conversion Rate pursuant to
Section 8.04. 
 (f) Nothing in this Section 8.03 shall prevent an adjustment to the Conversion Rate pursuant to
Section 8.04 in respect of a Make-Whole Fundamental Change. 
 Section 8.04. Adjustment of Conversion Rate. The
Conversion Rate shall be adjusted from time to time by the Issuer if any of the following events occurs, except that the Issuer shall not make any adjustments to the Conversion Rate if Holders of the Notes participate (other than in the case of a
share split or share combination), at the same time and upon the same terms as holders of the Common Stock and solely as a result of holding the Notes, in any of the transactions described in this Section 8.04, without having to convert their
Notes, as if they held a number of shares of Common Stock equal to (i) the Conversion Rate, multiplied by (ii) the principal amount of Notes held by such Holder of the Notes, divided by $1,000. 

  
 16 

 (a) If the Issuer issues solely shares of Common Stock as a dividend or distribution on all
or substantially all shares of its outstanding Common Stock, or if the Issuer effects a share split or share combination, the Conversion Rate shall be adjusted based on the following formula: 

 
 

 
 where, 
  

					
	 CR0
	 	=	  	 the Conversion Rate in effect immediately prior to the close of business on the Record Date of such dividend or

distribution, or immediately prior to the open of business on the effective date of such share split or share combination,

as the case may be;

			
	 CR'
	 	=	  	 the Conversion Rate in effect immediately after the close of business on the Record Date for such dividend or

distribution, or immediately after the open of business on the effective date of such share split or combination, as the case

may be;

			
	 OS0
	 	=	  	 the number of shares of Common Stock outstanding immediately prior to the close of business on the Record Date for

such dividend or distribution, or immediately prior to the open of business on the effective date of such share split or

combination, as the case may be; and

			
	 OS'
	 	=	  	 the number of shares of Common Stock outstanding immediately after giving effect to such dividend or distribution
or
 such share split or share combination, as the case may be.

 Any adjustment made under this Section 8.04(a) shall become effective immediately after the close of business on the
Record Date for such dividend or distribution, or immediately after the open of business on the Effective Date for such share split or share combination, as the case may be. If any dividend or distribution of the type described in this
Section 8.04(a) is declared that results in an adjustment under this clause Section 8.04(a) but not so paid or made or the outstanding shares of Common Stock are not split or combined, as the case may be, the Conversion Rate shall be
immediately readjusted, effective as of the date the Board of Directors determines not to pay such dividend or distribution or to effect such split or combination, to the Conversion Rate that would then be in effect if such dividend or distribution
or share split or share combination had not been declared or announced. 
 (b) If the Issuer distributes to all or substantially
all holders of its outstanding Common Stock any rights, options or warrants entitling them, for a period of not more than 45 calendar days from the declaration date for such distribution, to subscribe for or purchase shares of the Common Stock at a
price per share less than the average of the Last Reported Sale Prices of the Common Stock for the 10 consecutive Trading Day period ending on, and including, the Trading Day immediately preceding the declaration date for such issuance, the
Conversion Rate shall be increased based on the following formula: 

  
 17 

  
 

 
 where, 
  

					
	 CR0
	 	=	  	the Conversion Rate in effect immediately prior to the close of business on the Record Date for such distribution;
			
	 CR'
	 	=	  	the Conversion Rate in effect immediately after the close of business on the Record Date for such distribution;
			
	 OS0
	 	=	  	 the number of shares of Common Stock outstanding immediately prior to the close of business on the Record Date for

such distribution;

			
	 X
	 	=	  	the total number of shares of Common Stock issuable pursuant to such rights, options or warrants; and
			
	 Y
	 	=	  	 the number of shares of Common Stock equal to the aggregate price payable to exercise such rights, options or
warrants
 divided by the average of the Last Reported Sale Prices of the Common Stock over the 10 consecutive Trading Day

period ending on, and including, the Trading Day immediately preceding the declaration date for such distribution.

 Any increase made under this Section 8.04(b) shall be made successively whenever any such rights, options or warrants
are distributed and shall become effective immediately after the close of business on the Record Date for such distribution. To the extent that shares of the Common Stock are not delivered after the expiration of such rights, options or warrants,
the Conversion Rate shall be decreased to the Conversion Rate that would then be in effect had the increase with respect to the distribution of such rights, options or warrants been made on the basis of delivery of only the number of shares of
Common Stock actually delivered. If such rights, options or warrants are not so distributed, the Conversion Rate shall be decreased to the Conversion Rate that would then be in effect if such Record Date for such distribution had not been fixed.

 For purposes of this Section 8.04(b), in determining whether any rights, options or warrants entitle the holders to
subscribe for or purchase shares of Common Stock at less than such average of the Last Reported Sale Prices of the Common Stock for the 10 consecutive Trading Day period ending on, and including, the Trading Day immediately preceding the declaration
date for such distribution, and in determining the aggregate offering price of such shares of Common Stock, there shall be taken into account any consideration received by the Issuer for such rights, options or warrants and any amount payable on
exercise or conversion thereof, the value of such consideration, if other than cash, to be determined by the Board of Directors. 
 (c) If the Issuer distributes shares of its Capital Stock, evidences of its indebtedness, other assets or property of the Issuer or rights, options or warrants to acquire its Capital Stock or other
securities, to all or substantially all holders of the outstanding Common Stock, excluding (i) dividends or distributions as to which an adjustment was effected pursuant to Section 8.04(a)

  
 18 

 
or Section 8.04(b), (ii) dividends or distributions paid in cash as to which an adjustment was effected pursuant to Section 8.04(d), and (iii) Spin-Offs as to which the provisions set
forth below in this Section 8.04(c) shall apply (any of such shares of Capital Stock, evidences of indebtedness, other assets or property or rights, options or warrants to acquire Capital Stock or other securities of the Issuer, the
“Distributed Property”), then the Conversion Rate shall be increased based on the following formula: 
  

 
 where, 
  

					
	 CR0
	 	=	  	the Conversion Rate in effect immediately prior to the close of business on the Record Date for such distribution;
			
	 CR'
	 	=	  	the Conversion Rate in effect immediately after the close of business on the Record Date for such distribution;
			
	 SP0
	 	=	  	 the average of the Last Reported Sale Prices of the Common Stock over the 10 consecutive Trading Day period ending

on, and including, the Trading Day immediately preceding the Ex-Dividend Date for such distribution; and

			
	 FMV
	 	=	  	 the fair market value (as determined by the Board of Directors) of the Distributed Property with respect to each

outstanding share of the Common Stock as of the close of business on the Record Date for such distribution.

 Any increase made under the portion of this Section 8.04(c) above shall become effective
immediately after the close of business on the Record Date for such distribution. If such distribution is not so paid or made, the Conversion Rate shall be decreased to the Conversion Rate that would then be in effect if such distribution had not
been declared. Notwithstanding the foregoing, if “FMV” (as defined above) is equal to or greater than
“SP0” (as defined above), in lieu of the foregoing
increase, each Holder of a Note shall receive, in respect of each $1,000 principal amount thereof, at the same time and upon the same terms as holders of the Common Stock receive the Distributed Property, the amount of Distributed Property such
Holder would have received if such Holder owned a number of shares of Common Stock equal to the Conversion Rate in effect on the Record Date for the distribution. If the Board of Directors determines the “FMV” (as defined above) of any
distribution for purposes of this Section 8.04(c) by reference to the actual or when-issued trading market for any securities, it shall in doing so consider the prices in such market over the same period used in computing the Last Reported Sale
Prices of the Common Stock over the 10 consecutive Trading Day period ending on, and including, the Trading Day immediately preceding the Record Date for such distribution. 
 With respect to an adjustment pursuant to this Section 8.04(c) where there has been a distribution on the Common Stock of shares of Capital Stock of any class or series, or similar equity interest,
of or relating to a Subsidiary or other business unit of the Issuer, which Capital Stock or similar equity interest will be quoted or listed for trading on a U.S. National Securities Exchange after its distribution (a “Spin-Off”),
the Conversion Rate shall be increased based on the following formula: 

  
 19 

  
 

 
 where, 
  

					
	 CR0
	 	=	  	the Conversion Rate in effect immediately prior to the close of business on the Record Date for the Spin-Off;
			
	 CR'
	 	=	  	the Conversion Rate in effect immediately after the close of business on the Record Date for the Spin-Off;
			
	 FMV0
	 	=	  	 the average of the Last Reported Sale Prices of the Capital Stock or similar equity interest distributed to holders of
the
 Common Stock applicable to one share of the Common Stock (determined by reference to the definition of Last

Reported Sale Price as set forth in Section 1.01 as if references therein to Common Stock were to such Capital Stock or

similar equity interest) over the first 10 consecutive Trading Day period immediately following, and including, the

Ex-Dividend Date for the Spin-Off (the “Valuation Period”); and

			
	 MP0
	 	=	  	the average of the Last Reported Sale Prices of the Common Stock over the Valuation Period.

 The adjustment to the Conversion Rate under the preceding paragraph shall be calculated at the close of business on the
last Trading Day of the Valuation Period, but shall be given effect at the close of business on the Record Date for such Spin-Off; provided that, for purposes of determining the Conversion Rate in respect of any conversion after the close of
business on the Record Date for the Spin-Off but prior to the close of business on the 10th Trading Day immediately following, and including, the Ex-Dividend Date for the Spin-Off, references in the portion of this Section 8.04(c) to 10 Trading
Days shall be deemed replaced with such lesser number of Trading Days as have elapsed between the Ex-Dividend Date for such Spin-Off and the Conversion Date. 
 If any such distribution that constitutes a Spin-Off is declared but not made, and such distribution has resulted in an adjustment to the Conversion Rate, the Conversion Rate shall be re-adjusted,
effective as of the date the Board of Directors determines not to make such distribution, to be the Conversion Rate that would then be in effect if such distribution had not been declared. 

For purposes of this Section 8.04(c) (and subject in all respect to Section 8.11), rights, options or warrants distributed by
the Issuer to all holders of its Common Stock entitling them to subscribe for or purchase shares of the Issuer’s Capital Stock, including Common Stock (either initially or under certain circumstances), which rights, options or warrants, until
the occurrence of a specified event or events (“Trigger Event”): (i) are deemed to be transferred with such shares of the Common Stock; (ii) are not exercisable; and (iii) are also issued in respect of future

  
 20 

 
issuances of the Common Stock, shall be deemed not to have been distributed for purposes of this Section 8.04(c) (and no adjustment to the Conversion Rate under this Section Section 8.04(c)
will be required) until the occurrence of the earliest Trigger Event, whereupon such rights, options or warrants shall be deemed to have been distributed and an appropriate adjustment (if any is required) to the Conversion Rate shall be made under
this Section 8.04(c). If any such right, option or warrant, including any such existing rights, options or warrants distributed prior to the date of this Indenture, are subject to events, upon the occurrence of which such rights, options or warrants
become exercisable to purchase different securities, evidences of indebtedness or other assets, then the date of the occurrence of any and each such event shall be deemed to be the date of distribution and Record Date with respect to new rights,
options or warrants with such rights (in which case the existing rights, options or warrants shall be deemed to terminate and expire on such date without exercise by any of the holders thereof). In addition, in the event of any distribution (or
deemed distribution) of rights, options or warrants, or any Trigger Event or other event (of the type described in the immediately preceding sentence) with respect thereto that was counted for purposes of calculating a distribution amount for which
an adjustment to the Conversion Rate under this Section 8.04(c) was made, (1) in the case of any such rights, options or warrants that shall all have been redeemed or purchased without exercise by any holders thereof, upon such final redemption
or purchase (x) the Conversion Rate shall be readjusted as if such rights, options or warrants had not been issued and (y) the Conversion Rate shall then again be readjusted to give effect to such distribution, deemed distribution or
Trigger Event, as the case may be, as though it were a cash distribution, equal to the per share redemption or purchase price received by a holder or holders of Common Stock with respect to such rights, options or warrants (assuming such holder had
retained such rights, options or warrants), made to all holders of Common Stock as of the date of such redemption or purchase, and (2) in the case of such rights, options or warrants that shall have expired or been terminated without exercise
by any holders thereof, the Conversion Rate shall be readjusted as if such rights, options and warrants had not been issued. 

For purposes of Section 8.04(a), Section 8.04(b) and this Section 8.04(c), if any dividend or distribution to which this
Section 8.04(c) is applicable also includes one or both of: 
 (A) a dividend or distribution of shares of Common Stock to
which Section 8.04(a) is applicable (the “Clause A Distribution”); or 
 (B) a dividend or distribution of
rights, options or warrants to which Section 8.04(b) is applicable (the “Clause B Distribution”), 
 then (1) such
dividend or distribution, other than the Clause A Distribution and the Clause B Distribution, shall be deemed to be a dividend or distribution to which this Section 8.04(c) is applicable (the “Clause C Distribution”) and any
Conversion Rate adjustment required by this Section 8.04(c) with respect to such Clause C Distribution shall then be made, and (2) the Clause A Distribution and Clause B Distribution shall be deemed to immediately follow the Clause C
Distribution and any Conversion Rate adjustment required by Section 8.04(a) and Section Section 8.04(b) with respect thereto shall then be made, except that, if determined by the Issuer (I) the Record Date of the Clause A Distribution and
the Clause B Distribution shall be deemed to be the Record Date of the Clause C Distribution and (II) any shares of Common Stock included in the Clause A Distribution or Clause B Distribution shall be deemed not to be

  
 21 

 
“outstanding immediately prior to the close of business on the Record Date for such dividend or distribution or immediately after the open of business on the effective date of such share
split or share combination, as the case may be” within the meaning of Section 8.04(a) or “outstanding immediately prior to the close of business on the Record Date for such distribution” within the meaning of
Section 8.04(b). 
 (d) If the Issuer pays any cash dividend or distribution to all or substantially all holders of the
outstanding shares of Common Stock, the Conversion Rate shall be increased based on the following formula: 
  
 

 
 where, 
  

					
	 CR0
	 	=	  	 the Conversion Rate in effect immediately prior to the close of business on the Record Date for such dividend or

distribution;

			
	 CR'
	 	=	  	 the Conversion Rate in effect immediately after the close of business on the Record Date for such dividend or

distribution;

			
	 SP0
	 	=	  	 the Last Reported Sale Price of the Common Stock on the Trading Day immediately preceding the Ex-Dividend Date for

such dividend or distribution; and

			
	 C
	 	=	  	the amount in cash per share the Issuer distributes to all or substantially all holders of its outstanding Common Stock.

 Any increase pursuant to this Section 8.04(d) shall become effective immediately after the close
of business on the Record Date for such dividend or distribution. If such dividend or distribution is not so paid, the Conversion Rate shall be decreased, effective as of the date the Board of Directors determines not to make or pay such dividend or
distribution, to the Conversion Rate that would then be in effect if such dividend or distribution had not been declared. Notwithstanding the foregoing, if “C” (as defined above) is equal to or greater than “SP0” (as defined above), in lieu of the foregoing increase, each Holder
of a Note shall receive, for each $1,000 principal amount of Notes, at the same time and upon the same terms as holders of shares of the Common Stock, the amount of cash that such Holder would have received if such Holder owned a number of shares of
Common Stock equal to the Conversion Rate on the Record Date for such cash dividend or distribution. For the avoidance of doubt, there will not be any adjustment to the Conversion Rate under this Section 8.04(d) as a result of any distribution
of Reference Property to holders of the Common Stock in connection with any Merger Event. 
 (e) If the Issuer or any of its
Subsidiaries makes a payment in respect of a tender offer or exchange offer for the Common Stock, if the cash and value of any other consideration included in the payment per share of Common Stock exceeds the Last Reported Sale Price of the Common
Stock on the Trading Day next succeeding the last date on which tenders or exchanges may be made pursuant to such tender offer or exchange offer (the “Expiration Date”), the Conversion Rate shall be increased based on the following
formula: 

  
 22 

  
 

 
 where, 
  

					
	 CR0
	 	=	  	the Conversion Rate in effect immediately prior to the close of business on the Expiration Date;
			
	 CR'
	 	=	  	the Conversion Rate in effect immediately after the close of business on the Expiration Date;
			
	 FMV
	 	=	  	 the aggregate value, on the Expiration Date, of all cash and the fair market value (as determined by the Board of

Directors) of any other consideration paid or payable for shares of Common Stock validly tendered or exchanged as of

the Expiration Date;

			
	 OS'
	 	=	  	 the number of shares of Common Stock outstanding immediately after the time (the “Expiration Time”) that the
tender
 offer or exchange offer expires (after giving effect to such tender offer or exchange offer);

			
	 OS0
	 	=	  	 the number of shares of Common Stock outstanding immediately prior to the Expiration Time (prior to giving effect
to
 such tender offer or exchange offer); and

			
	 SP'
	 	=	  	 the average of the Last Reported Sale Prices of the Common Stock over the 10 consecutive Trading Day period

commencing on, and including, the Trading Day next succeeding the Expiration Date.

 The adjustment to the Conversion Rate under this Section 8.04(e) shall be calculated at the close of business on the
10th Trading Day immediately following the Expiration Date, but shall be given effect at the close of business on the Expiration Date; provided that, for purposes of determining the Conversion Rate in respect of any conversion within the 10
Trading Days immediately following, and including, the Expiration Date, references in this Section 8.04(e) with respect to 10 Trading Days shall be deemed replaced with such lesser number of Trading Days as have elapsed between the Expiration
Date and the Conversion Date. 
 (f) If the application of the formulas in clauses (a), (b), (c), (d) and (e) of this
Section 8.04 would result in a decrease in the Conversion Rate, no adjustment to the Conversion Rate will be made (other than as a result of a reverse share split or share combination). In no event will the Issuer adjust the Conversion Rate to
the extent that the adjustment would reduce the Conversion Price below the par value per share of its Common Stock. 
 (g)
Except as stated herein, the Issuer shall not adjust the Conversion Rate for the issuance of shares of its Common Stock or any securities convertible into or exchangeable for shares of its Common Stock or the right to purchase shares of its Common
Stock or such convertible or exchangeable securities. 

  
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 (h) In addition to those adjustments required by clauses (a), (b), (c), (d) and
(e) of this Section 8.04, and to the extent permitted by applicable law and subject to the applicable rules of The NASDAQ Global Select Market, (i) the Issuer may increase the Conversion Rate of the Notes by any amount for a period of
at least 20 Business Days if the Board of Directors determines that such increase would be in the Issuer’s best interest and (ii) the Issuer may (but is not required to) increase the Conversion Rate to avoid or diminish any income tax to
holders of Common Stock or rights to purchase shares of Common Stock in connection with a dividend or distribution of shares (or rights to acquire shares of Common Stock) or similar event. Whenever the Conversion Rate is increased pursuant to the
preceding two sentences, the Issuer shall mail to the Holder of each Note at its last address appearing on the Register a notice of the increase at least 15 days prior to the date the increased Conversion Rate takes effect, and such notice shall
state the increased Conversion Rate and the period during which it will be in effect. 
 (i) Notwithstanding anything to the
contrary in Section 8.04, for the avoidance of doubt, the Conversion Rate shall not be adjusted: 
 (i)
upon the issuance of any shares of Common Stock pursuant to any present or future plan providing for the reinvestment of dividends or interest payable on the Issuer’s securities and the investment of additional optional amounts in shares of
Common Stock under any plan; 
 (ii) upon the issuance of any shares of Common Stock or options or rights to
purchase shares of Common Stock pursuant to any present or future employee, director or consultant benefit plan or program of or assumed by the Issuer or any of the its Subsidiaries; 

(iii) upon the issuance of any shares of Common Stock pursuant to any option, warrant, right or exercisable, exchangeable
or convertible security not described in clause (ii) of this subsection and outstanding as of the date the Notes were first issued, subject to Section 8.11; 

(iv) solely for a change in the par value of the Common Stock; or 

(v) for accrued and unpaid interest on the Notes, if any. 

(j) All calculations and other determinations under this Article 8 shall be made by the Issuer and all calculations of the Conversion
Rate shall be made to the nearest one-ten thousandth (1/10,000) of a share. 
 (k) The Issuer will not be required to make
an adjustment in the Conversion Rate unless the adjustment would require a change of at least 1% in the Conversion Rate. However, the Issuer will carry forward any adjustment that is less than 1% of the Conversion Rate, take such carried-forward
adjustments into account in any subsequent adjustment, and make such carried forward adjustments, regardless of whether the aggregate adjustment is less than 1%, (i) annually on the anniversary of the first date of issue of the Notes and
otherwise (ii)(x) on the Conversion Date for any Notes or (y) on the effective date of any Fundamental Change or Make-Whole Fundamental Change, unless such adjustment has already been made. 

  
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 (l) Whenever the Conversion Rate is adjusted as herein provided, the Issuer shall promptly
file with the Trustee (and the conversion agent if not the Trustee) an Officer’s Certificate setting forth the Conversion Rate after such adjustment and setting forth a brief statement of the facts requiring such adjustment. Unless and until a
Responsible Officer of the Trustee shall have received such Officer’s Certificate, the Trustee shall not be deemed to have knowledge of any adjustment of the Conversion Rate and may assume without inquiry that the last Conversion Rate of which
it has knowledge is still in effect. Promptly after delivery of such certificate, the Issuer shall prepare a notice of such adjustment of the Conversion Rate setting forth the adjusted Conversion Rate and the date on which each adjustment becomes
effective and shall mail such notice of such adjustment of the Conversion Rate to each Holder of the Notes at its last address appearing on the Register. Failure to deliver such notice shall not affect the legality or validity of any such
adjustment. 
 (m) For purposes of this Section 8.04, the number of shares of Common Stock at any time outstanding shall
not include shares held in the treasury of the Issuer so long as the Issuer does not pay any dividend or make any distribution on shares of Common Stock held in the treasury of the Issuer, but shall include shares issuable in respect of scrip
certificates issued in lieu of fractions of shares of Common Stock. 
 Section 8.05. Adjustments of Prices. Whenever any
provision of the Indenture requires the Issuer to calculate the Last Reported Sale Prices or the Stock Price for purposes of a Make-Whole Fundamental Change over a span of multiple days, the Board of Directors shall make appropriate adjustments to
each to account for any adjustment to the Conversion Rate that becomes effective, or any event requiring an adjustment to the Conversion Rate where the Record Date of the event occurs, at any time during the period when such Last Reported Sale
Prices or Stock Prices are to be calculated. 
 Section 8.06. Shares to be Fully Paid. The Issuer shall provide, free
from preemptive rights, out of its authorized but unissued shares that are not reserved for other purposes or shares held in treasury, sufficient shares of Common Stock to provide for conversion of the Notes from time to time as such Notes are
presented for conversion (assuming that at the time of computation of such number of shares, all such Notes would be converted by a single Holder of the Notes). 
 Section 8.07. Effect of Recapitalizations, Reclassifications and Changes of the shares of Common Stock. 
 (a) In the case of: 
 (i) any recapitalization, reclassification
or change of the Common Stock (other than changes resulting from a share split or combination), 
 (ii) any
consolidation, merger or combination involving the Issuer, 
 (iii) any sale, lease or other transfer to a third
party of the consolidated assets of the Issuer and its Subsidiaries substantially as an entirety, or 

  
 25 

 (iv) any statutory share exchange, 

in each case, as a result of which the shares of Common Stock would be converted into, or exchanged for, stock, other securities, other property or
assets (including cash or any combination thereof) (any such event, a “Merger Event”), then, at and after the effective time of such Merger Event, the right to convert each $1,000 principal amount of Notes shall be changed into a
right to convert such principal amount of Notes into the kind and amount of shares of stock, other securities or other property or assets (including cash or any combination thereof) that a holder of a number of shares of Common Stock equal to the
Conversion Rate immediately prior to such Merger Event would have owned or been entitled to receive (the “Reference Property”, with each “unit of Reference Property” meaning the kind and amount of Reference Property
that a holder of one share of Common Stock is entitled to receive) upon such Merger Event and, prior to or at the effective time of such Merger Event, the Issuer or the successor or purchasing Person, as the case may be, shall execute with the
Trustee a supplemental indenture permitted under Section 7.01(m) of the Base Indenture providing for such change in the right to convert each $1,000 principal amount of Notes; provided, however, that at and after the effective
time of the Merger Event the number of shares of Common Stock otherwise deliverable upon conversion of the Notes in accordance with Section 8.02 shall instead be deliverable in the amount and type of Reference Property that a holder of that
number of shares of Common Stock would have received in such Merger Event. 
 If the Merger Event causes the Common Stock to be
converted into, or exchanged for, the right to receive more than a single type of consideration (determined based in part upon any form of stockholder election), then (i) the Reference Property into which the Notes will be convertible shall be
deemed to be the weighted average of the types and amounts of consideration received by the holders of Common Stock that affirmatively make such an election, and (ii) the unit of Reference Property for purposes of the immediately preceding
paragraph shall refer to the consideration referred to in clause (i) attributable to one share of Common Stock. The Issuer shall notify Holders, the Trustee and the conversion agent (if other than the Trustee) of such weighted average as soon
as practicable after such determination is made. 
 Such supplemental indenture described in the second immediately preceding
paragraph shall provide for anti-dilution and other adjustments that shall be as nearly equivalent as is possible to the adjustments provided for in this Article 8. If, in the case of any Merger Event, the Reference Property includes shares of
stock, securities or other property or assets (including cash or any combination thereof) of a Person other than the successor or purchasing corporation, as the case may be, in such Merger Event, then such supplemental indenture shall also be
executed by such other Person and shall contain such additional provisions to protect the interests of the Holders of the Notes as the Board of Directors shall reasonably consider necessary by reason of the foregoing, including to the extent
required by the Board of Directors and practicable the provisions providing for the purchase rights set forth in Article 9. 

(b) In the event the Issuer shall execute a supplemental indenture pursuant to subsection (a) of this Section 8.07, the Issuer
shall promptly file with the Trustee an Officer’s Certificate briefly stating the reasons therefor, the kind or amount of cash, securities or property or asset that will comprise a unit of Reference Property after any such Merger Event, any
adjustment to be made with respect thereto and that all conditions precedent have been complied 

  
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with, and shall promptly mail notice thereof to all Holders. The Issuer shall cause notice of the execution of such supplemental indenture to be mailed to each Holder, at its address appearing on
the Register, within 20 days after execution thereof. Failure to deliver such notice shall not affect the legality or validity of such supplemental indenture. 
 (c) The Issuer shall not become a party to any Merger Event unless its terms are consistent with this Section 8.07. None of the foregoing provisions shall affect the right of a Holder of the Notes to
convert its Notes into shares of Common Stock as set forth in Section 8.01 and Section 8.02 prior to the effective date of such Merger Event. 
 (d) The above provisions of this Section shall similarly apply to successive Merger Events. 
 Section 8.08. Certain Covenants. (a) The Issuer covenants that all shares of Common Stock issued upon conversion of Notes will be fully paid and non-assessable by the Issuer and free from all
taxes, liens and charges with respect to the issue thereof. 
 (b) The Issuer covenants that, if any shares of Common Stock to
be provided for the purpose of conversion of Notes hereunder require registration with or approval of any governmental authority under any federal or state law before such shares may be validly issued upon conversion, the Issuer will, to the extent
then permitted by the rules and interpretations of the Commission, secure such registration or approval, as the case may be. 

(c) The Issuer further covenants that if at any time the Common Stock shall be listed on any national securities exchange or automated
quotation system the Issuer will list and keep listed, so long as the Common Stock shall be so listed on such exchange or automated quotation system, any Common Stock issuable upon conversion of the Notes. 

Section 8.09. Responsibility of Trustee. The Trustee and any other conversion agent shall not at any time be under any duty or
responsibility to any Holder to determine the Conversion Rate (or any adjustment thereto) or whether any facts exist that may require any adjustment (including any increase) of the Conversion Rate, or with respect to the nature or extent or
calculation of any such adjustment when made, or with respect to the method employed, or herein or in any supplemental indenture provided to be employed, in making the same. The Trustee and any other conversion agent shall not be accountable with
respect to the validity or value (or the kind or amount) of any shares of Common Stock, or of any securities, property or cash that may at any time be issued or delivered upon the conversion of any Note; and the Trustee and any other conversion
agent make no representations with respect thereto. Neither the Trustee nor any conversion agent shall be responsible for any failure of the Issuer to issue, transfer or deliver any shares of Common Stock or stock certificates or other securities or
property or cash upon the surrender of any Note for the purpose of conversion or to comply with any of the duties, responsibilities or covenants of the Issuer contained in this Article. Without limiting the generality of the foregoing, neither the
Trustee nor any conversion agent shall be under any responsibility to determine the correctness of any provisions contained in any supplemental indenture entered into pursuant to Section 8.07 relating either to the kind or amount of shares of
stock or securities or property (including cash) receivable by Holders of the Notes upon the conversion of their Notes after any event referred to in such Section 8.07 or to 

  
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any adjustment to be made with respect thereto, but, subject to the provisions of Section 5.05 of the Base Indenture, may accept (without any independent investigation) as conclusive
evidence of the correctness of any such provisions, and shall be protected in relying upon, the Officer’s Certificate (which the Issuer shall be obligated to file with the Trustee prior to the execution of any such supplemental indenture) with
respect thereto. 
 Section 8.10. Notice to Holders Prior to Certain Actions. In case of any: 

(a) action by the Issuer or one of its Subsidiaries that would require an adjustment in the Conversion Rate pursuant to Section 8.04
or Section 8.11; 
 (b) Merger Event; or 
 (c) voluntary or involuntary dissolution, liquidation or winding-up of the Issuer or any of its Subsidiaries; 
 then, in each case (unless notice of such event is otherwise required pursuant to another provision of the Indenture, excluding for the avoidance of doubt Section 8.04(l)), the Issuer shall cause to
be filed with the Trustee and the conversion agent (if other than the Trustee) and to be mailed to each Holder at its address appearing on the Register, as promptly as possible but in any event at least 20 days prior to the applicable date
hereinafter specified, a notice stating (i) the date on which a record is to be taken for the purpose of such action by the Issuer or one of its Subsidiaries or, if a record is not to be taken, the date as of which the holders of Common Stock
of record are to be determined for the purposes of such action by the Issuer or one of its Subsidiaries, or (ii) the date on which such Merger Event, dissolution, liquidation or winding-up is expected to become effective or occur, and, if
applicable, the date as of which it is expected that holders of Common Stock of record shall be entitled to exchange their Common Stock for securities or other property deliverable upon such Merger Event, dissolution, liquidation or winding-up.
Failure to give such notice, or any defect therein, shall not affect the legality or validity of such action by the Issuer or one of its Subsidiaries, Merger Event, dissolution, liquidation or winding-up. 

Section 8.11. Shareholder Rights Plans. To the extent the Issuer has a stockholder rights plan in effect upon conversion of the
Notes, each share of Common Stock issued upon such conversion shall be entitled to receive the appropriate number of rights, if any, and the certificates representing the Common Stock issued upon such conversion shall bear such legends, if any, in
each case as may be provided by the terms of any such stockholder rights plan, as the same may be amended from time to time. If at any time prior to conversion, however, the rights have separated from the shares of Common Stock in accordance with
the provisions of the applicable stockholder rights plan so that the Holders would not be entitled to receive any rights in respect of Common Stock issuable upon conversion of the Notes, the Conversion Rate shall be adjusted at the time of
separation as if the Issuer distributed to all or substantially all holders of outstanding Common Stock shares of Capital Stock of the Issuer, evidences of its indebtedness, other assets or property or rights, options or warrants to acquire its
Capital Stock or other securities as provided in Section 8.04(c), subject to readjustment in the event of the expiration, termination or redemption of such rights. 

  
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 ARTICLE 9 
 REPURCHASE OF NOTES AT OPTION OF HOLDERS 

Section 9.01. Repurchase at Option of Holders of the Notes Upon a Fundamental Change. (a) If a Fundamental Change occurs at
any time, each Holder of the Notes shall have the right, at such Holder’s option, to require the Issuer to repurchase for cash all of such Holder’s Notes, or any portion of the principal thereof that is equal to $1,000 principal amount or
a multiple of $1,000 principal amount, on the date (the “Fundamental Change Repurchase Date”) specified by the Issuer that is not less than 20 calendar days or more than 35 calendar days following the date of the Fundamental Change
Issuer Notice at a repurchase price equal to 100% of the principal amount of the Notes to be repurchased, plus accrued and unpaid interest to, but excluding, the Fundamental Change Repurchase Date (the “Fundamental Change Repurchase
Price”); provided that if the Fundamental Change Repurchase Date falls after a Regular Record Date but on or prior to the Interest Payment Date to which such Regular Record Date relates, then the Issuer shall instead pay the full
amount of accrued and unpaid interest to the Holder of record on such Regular Record Date, and the Fundamental Change Repurchase Price shall be equal to 100% of the principal amount of Notes to be repurchased pursuant to this Article 9. 

(b) On or before the 15th calendar day after the occurrence of a Fundamental Change, the Issuer shall provide to all Holders of the Notes and
the Trustee and the paying agent (in the case of a paying agent other than the Trustee) a notice (the “Fundamental Change Issuer Notice”) of the occurrence of the effective date of the Fundamental Change and of the repurchase right
at the option of the Holders arising as a result thereof. Each Fundamental Change Issuer Notice shall specify: 

(i) the events causing the Fundamental Change; 

(ii) the date the Fundamental Change occurred, and whether the Fundamental Change is a Make-Whole Fundamental Change, in
which case the Effective Date of the Make-Whole Fundamental Change shall be given; 
 (iii) the last date on
which a Holder of the Notes may exercise the repurchase right pursuant to this Article 9; 
 (iv) the
Fundamental Change Repurchase Price; 
 (v) the Fundamental Change Repurchase Date; 

(vi) the name and address of the paying agent and the conversion agent; 

(vii) if applicable, the Conversion Rate and any adjustments to the Conversion Rate made or to be made on account of such
Fundamental Change; 
 (viii) if applicable, that the Notes with respect to which a Fundamental Change
Repurchase Notice has been delivered by a Holder of the Notes may be converted only if such Holder withdraws the Fundamental Change Repurchase Notice in accordance with the terms of the Indenture; and 

  
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 (ix) the procedures that Holders of the Notes must follow to require the
Issuer to repurchase their Notes. 
 At the Issuer’s request, the Trustee shall give such notice in the Issuer’s name
and at the Issuer’s expense; provided, however, that, in all cases, the text of such Fundamental Change Issuer Notice shall be prepared by the Issuer. 
 Such notice shall be by first class mail to the Trustee, to the paying agent and to each Holder at its address shown in the Register (and to beneficial owners as required by applicable law) or, in the
case of Global Securities, in accordance with the applicable procedures of the Depositary. Contemporaneously with providing such notice, the Issuer shall publish a notice containing the information set forth in the Fundamental Change Issuer Notice
in a newspaper of general circulation in The City of New York or publish such information on the Issuer’s website or through such other public medium as the Issuer may use at that time. 

No failure of the Issuer to give the foregoing notices and no defect therein shall limit the repurchase rights of the Holders of the
Notes or affect the validity of the proceedings for the repurchase of the Notes pursuant to this Section 9.01. 
 (c)
Repurchases of Notes under this Section 9.01 shall be made, at the option of the Holder thereof, upon: 

(i) delivery to the paying agent by a Holder of a duly completed notice (the “Fundamental Change Repurchase
Notice”) in the form set forth in Attachment 2 to the Form of Note attached hereto as Exhibit A, if the Notes are certificated Notes, or in compliance with the Depositary’s procedures for surrendering interests in Global Securities, if
the Notes are Global Securities, in each case prior to the close of business on the Business Day immediately preceding the Fundamental Change Repurchase Date; and 

(ii) delivery of the Notes, if the Notes are certificated Notes, to the paying agent at any time after delivery of the
Fundamental Change Repurchase Notice (together with all necessary endorsements for transfer) at the Corporate Trust Office of the paying agent, or book-entry transfer of the Notes, if the Notes are Global Securities, in compliance with the
procedures of the Depositary, in each case such delivery being a condition to receipt by the Holder of the Fundamental Change Repurchase Price therefor. 
 (d) The Fundamental Change Repurchase Notice in respect of any Notes to be repurchased shall state: 
 (i) in the case of certificated Notes, the certificate numbers of the Notes to be delivered for repurchase; 

  
 30 

 (ii) the portion of the principal amount of the Notes to be repurchased,
which must be $1,000 or a multiple thereof; and 
 (iii) that the Notes are to be repurchased by the Issuer
pursuant to the applicable provisions of the Notes and the Indenture; 
 provided, however, that if the Notes are Global
Securities, the Fundamental Change Repurchase Notice must comply with applicable procedures of the Depositary. 

Notwithstanding anything herein to the contrary, any Holder delivering to the paying agent the Fundamental Change Repurchase Notice
contemplated by this Section 9.01 shall have the right to withdraw, in whole or in part, such Fundamental Change Repurchase Notice at any time prior to the close of business on the Business Day immediately preceding the Fundamental Change
Repurchase Date by delivery of a written notice of withdrawal to the paying agent in accordance with Section 9.02. 
 The
paying agent shall promptly notify the Issuer of the receipt by it of any Fundamental Change Repurchase Notice or written notice of withdrawal thereof. 
 (e) Notwithstanding the foregoing, no Notes may be repurchased on any date by the Issuer at the option of the Holders upon a Fundamental Change if the principal amount of the Notes has been accelerated
(other than in connection with a default by the Issuer in the payment of the Fundamental Change Repurchase Price with respect to such Notes), and such acceleration has not been rescinded, on or prior to such date. The paying agent will promptly
return to the respective Holders thereof any certificated Notes held by it during the acceleration of the Notes (except in the case of an acceleration resulting from a default by the Issuer in the payment of the Fundamental Change Repurchase Price
with respect to such Notes), or any instructions for book-entry transfer of the Notes in compliance with the procedures of the Depositary shall be deemed to have been canceled, and, upon such return or cancellation, as the case may be, the
Fundamental Change Repurchase Notice with respect thereto shall be deemed to have been withdrawn. 
 Section 9.02. Withdrawal
of Fundamental Change Repurchase Notice. A Fundamental Change Repurchase Notice may be withdrawn (in whole or in part) by means of a written notice of withdrawal delivered to the Corporate Trust Office of the paying agent in accordance with this
Section 9.02 at any time prior to the close of business on the Business Day immediately preceding the Fundamental Change Repurchase Date, specifying: 
 (i) the principal amount of the Notes with respect to which such notice of withdrawal is being submitted, which must be $1,000 or a multiple thereof; 

(ii) if certificated Notes have been issued, the certificate number of the Note in respect of which such notice of
withdrawal is being submitted; and 
 (iii) the principal amount, if any, of such Note that remains subject to
the original Fundamental Change Repurchase Notice which portion must be in principal amounts of $1,000 or a multiple thereof; 

  
 31 

 provided, however, that if the Notes are Global Securities, the notice must comply with
applicable procedures of the Depositary. 
 Section 9.03. Deposit of Fundamental Change Repurchase Price. (a) The Issuer
shall deposit with the Trustee (or other paying agent appointed by the Issuer, or if the Issuer is acting as its own paying agent, set aside, segregate and hold in trust as provided in Section 3.03 of the Base Indenture) on or prior to 11:00
a.m., New York City time, on the Fundamental Change Repurchase Date an amount of money sufficient to repurchase all of the Notes to be repurchased at the appropriate Fundamental Change Repurchase Price. Subject to receipt of funds and/or Notes by
the Trustee (or other paying agent appointed by the Issuer), payment for Notes surrendered for repurchase (and not withdrawn prior to the close of business on the Business Day immediately preceding the Fundamental Change Repurchase Date) will be
made on the later of (i) the Fundamental Change Repurchase Date with respect to such Note (provided the Holder has satisfied the conditions in Section 9.01) and (ii) the time of book-entry transfer or the delivery of such Note
to the Trustee (or other paying agent appointed by the Issuer) by the Holder thereof in the manner required by Section 9.01 by mailing checks for the amount payable to the Holders of such Notes entitled thereto as they shall appear in the
Register; provided, however, that payments to the Depositary shall be made by wire transfer of immediately available funds to the account of the Depositary or its nominee. The Trustee shall, promptly after such payment and upon written
demand by the Issuer, return to the Issuer any funds in excess of the Fundamental Change Repurchase Price. 
 (b) If by 11:00
a.m. New York City time, on the Fundamental Change Repurchase Date the Trustee (or other paying agent appointed by the Issuer) holds money sufficient to make payment on all the Notes or portions thereof that are to be repurchased on such Fundamental
Change Repurchase Date then: 
 (i) such Notes shall cease to be Outstanding, 

(ii) interest shall cease to accrue on such Notes (whether or not book-entry transfer of the Notes has been made or the
Notes have been delivered to the Trustee or paying agent), and 
 (iii) all other rights of the Holders of such
Notes will terminate (other than the right to receive the Fundamental Change Repurchase Price and, if the Fundamental Change Repurchase Date falls after a Regular Record Date but on or prior to the related Interest Payment Date, the right of the
Holder of record on such Regular Record Date to receive the related interest payment). 
 (c) Upon surrender of a Note that is
to be repurchased in part pursuant to Section 9.01, the Issuer shall execute and the Trustee shall authenticate and deliver to the Holder a new Note in an authorized denomination equal in principal amount to the unrepurchased portion of the
Note surrendered, without payment of any service charge. 
 Section 9.04. Covenant to Comply with Applicable Laws Upon
Repurchase of Notes. In connection with any repurchase offer pursuant to a Fundamental Change Issuer Notice, the Issuer shall: 

  
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 (a) if required, comply with the provisions of Rule 13e-4, Rule 14e-1 and any other tender
offer rules under the Exchange Act that may then be applicable; 
 (b) if required, file a Schedule TO or any other required
schedule under the Exchange Act; and 
 (c) otherwise comply with all federal and state securities laws in connection with any
offer by the Issuer to repurchase the Notes; 
 in each case, so as to permit the rights and obligations under this Article 9 to be exercised in
the time and in the manner specified in this Article 9. 
 ARTICLE 10 

OPTIONAL REDEMPTION 
 Section 10.01. Applicability of Article 11 of the Base Indenture. Subject to Section 2.01 hereof, the provisions of Article 11 of the Base Indenture, as supplemented by the provisions of this
Supplemental Indenture, shall apply to the Notes. No sinking fund is provided for the Notes. 
 Section 10.02. Optional
Redemption on or Prior to November 30, 2012. If the Issuer does not consummate the Merger or the Merger Agreement is terminated on or prior to September 30, 2012, the Issuer may redeem, upon notice as set forth in Section 11.02 of the
Base Indenture, all, but not less than all, of the Outstanding Notes for cash on a redemption date to occur on or prior to November 30, 2012, at a redemption price for each $1,000 principal amount of Notes to be redeemed equal to the sum of
(i) $1,010, (ii) accrued and unpaid interest on such Notes to, but excluding, the redemption date (unless the redemption date falls after a Regular Record Date but on or prior to the immediately succeeding Interest Payment Date, in which
case the Issuer shall pay the full amount of accrued and unpaid interest to Holders of record of such Notes as of the close of business on such Regular Record Date, and the redemption price shall not include any accrued and unpaid interest on the
Notes) and (iii) 75% of the difference, if positive, of the Redemption Conversion Value over the Initial Conversion Value. Following November 30, 2012, the Notes shall not be redeemable at the Issuer’s option prior to July 1,
2017. 
 Section 10.03. Optional Redemption Upon Satisfaction Of Sale Price Condition. On or after July 1, 2017, if
the Last Reported Sale Price of the Common Stock has been at least 130% of the Conversion Price for at least 20 Trading Days (whether or not consecutive) during any 30 consecutive Trading Day period ending within five Trading Days prior to the date
on which the Issuer provides notice of redemption as set forth in Section 11.02 of the Base Indenture, the Issuer may redeem for cash all or part of the Outstanding Notes, upon notice as set forth in Section 11.02 of the Base Indenture, at a
redemption price equal to 100% of the principal amount of the Notes to be redeemed, plus accrued and unpaid interest, if any, to, but excluding, the redemption date (unless the redemption date falls after a Regular Record Date but on or prior to the
immediately succeeding Interest Payment Date, in which case interest accrued to the Interest Payment Date will be paid to Holders of record of such Notes on such Regular Record Date, and the redemption price will be equal to 100% of the principal
amount of the Notes to be redeemed). 

  
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 Section 10.04. Conversion After Issuance Of A Redemption Notice. If the Issuer calls
Notes for redemption pursuant to Section 10.02 or Section 10.03, a Holder may convert its Notes only until the close of business on the Scheduled Trading Day immediately preceding the relevant redemption date unless the Issuer fails to pay
the applicable redemption price (in which case a Holder may convert such Notes until the applicable redemption price has been paid or duly provided for). 
 ARTICLE 11 
 MISCELLANEOUS PROVISIONS 

Section 11.01. Governing Law. THE INDENTURE AND EACH NOTE SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE
STATE OF NEW YORK. 
 Section 11.02. No Security Interest Created. Nothing in the Indenture or in the Notes, expressed or
implied, shall be construed to constitute a security interest under the Uniform Commercial Code or similar legislation, as now or hereafter enacted and in effect, in any jurisdiction. 

Section 11.03. Benefits of Indenture. Nothing in the Indenture or in the Notes, expressed or implied, shall give to any Person,
other than the parties hereto, any paying agent, any conversion agent, any authenticating agent, any Registrar and their successors hereunder or the Holders of the Notes, any benefit or any legal or equitable right, remedy or claim under the
Indenture. 
 Section 11.04. Effect of Headings. The article and section headings herein and in the Table of Contents are
for convenience only and shall not affect the construction hereof. 
 Section 11.05. Supplemental Indenture May be Executed
in Counterparts. This Supplemental Indenture may be executed in any number of counterparts, each of which shall be an original; but such counterparts shall together constitute but one and the same instrument. The exchange of copies of this
Supplemental Indenture and of signature pages by facsimile or PDF transmission shall constitute effective execution and delivery of this Supplemental Indenture as to the parties hereto and may be used in lieu of the original Supplemental Indenture
for all purposes. Signatures of the parties hereto transmitted by facsimile or PDF shall be deemed to be their original signatures for all purposes. 
 Section 11.06. Severability. In case any provision in the Indenture or the Notes shall be invalid, illegal or unenforceable, the validity, legality and enforceability of the remaining provisions
shall not in any way be affected or impaired thereby. 
 Section 11.07. Ratification of Base Indenture. Except as amended
hereby with respect to the Notes, the Base Indenture, as amended and supplemented by this Supplemental Indenture, is in all respects ratified and confirmed, and this Supplemental Indenture shall be deemed part of the Base Indenture in the manner and
to the extent herein and therein provided. For the avoidance of doubt, each of the Issuer and each Holder, by its acceptance of such Notes, 

  
 34 

 
acknowledges and agrees that all of the rights, privileges, protections, immunities and benefits afforded to the Trustee under the Base Indenture are deemed to be incorporated herein, and shall
be enforceable by the Trustee, whether acting as Trustee, paying agent, Registrar or conversion agent hereunder, as if set forth herein in full. 
 Section 11.08. Calculations. The Issuer shall be responsible for making all calculations called for under the Notes. These calculations include, but are not limited to, determinations of the Last
Reported Sale Prices of the Common Stock, accrued interest payable on the Notes, the Conversion Rate of the Notes. The Issuer shall make all these calculations in good faith and, absent manifest error, the Issuer’s calculations shall be final
and binding on Holders. The Issuer shall provide a schedule of its calculations to each of the Trustee and the conversion agent, and each of the Trustee and conversion agent is entitled to rely conclusively upon the accuracy of the Issuer’s
calculations without independent verification. The Trustee shall forward the Issuer’s calculations to any Holder upon the request of such Holder at the sole cost and expense of the Issuer. None of the Trustee, conversion agent or paying agent
shall be responsible or liable for the calculations of the Issuer. 
 Section 11.09. Trustee. Neither the Trustee nor any
of its agents shall be responsible for the validity or sufficiency of this Supplemental Indenture, nor for the recitals herein. 

  
 35 

 IN WITNESS WHEREOF, the parties hereto have caused this Supplemental Indenture to be duly executed as of the
date first written above. 
  

					
	AFFYMETRIX, INC.
		
	By:	 	/s/ Timothy C. Barabe
		 	Name:	 	Timothy C. Barabe
		 	 Title:
	 	Executive Vice President and Chief Financial Officer

  

					
	 THE BANK OF NEW YORK MELLON
     TRUST COMPANY, N.A., as Trustee

		
	By:	 	/s/ Melonee Young
		 	Name:	 	Melonee Young
		 	 Title:
	 	 Vice President

  

 EXHIBIT A 
 [FORM OF FACE OF NOTE] 
 [INCLUDE FOLLOWING LEGEND IF A GLOBAL NOTE] 

UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION
(“DTC”), NEW YORK, NEW YORK, TO THE COMPANY OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED
REPRESENTATIVE OF DTC (AND ANY PAYMENT IS MADE TO CEDE & CO., OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL
INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN. 
 TRANSFERS OF THIS GLOBAL SECURITY SHALL
BE LIMITED TO TRANSFERS IN WHOLE, BUT NOT IN PART, TO NOMINEES OF DTC OR TO A SUCCESSOR THEREOF OR SUCH SUCCESSOR’S NOMINEE AND TRANSFERS OF PORTIONS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS MADE IN ACCORDANCE WITH THE RESTRICTIONS
SET FORTH IN THE INDENTURE REFERRED TO HEREIN. 

  
 A-1

 AFFYMETRIX, INC. 
 4.00% Convertible Senior Note due 2019 
 No.
[            ]                             
                                         
                       [Initially]1
$[                    ] 
 CUSIP No.

 Affymetrix, Inc., a corporation duly organized and validly existing under the laws of the State of
Delaware (the “Issuer,” which term includes any successor corporation or other entity under the Indenture referred to on the reverse hereof), for value received hereby promises to pay to
[                    
]2[CEDE & CO.]3, or registered assigns, the principal sum [of
$                    
]4[as set forth in the “Schedule of Exchanges of
Notes” attached hereto], which amount, taken together with the principal amounts of all other Outstanding Notes, shall not, unless permitted by the Indenture, exceed $105,000,000 in aggregate at any time (as increased by an amount equal to the
aggregate principal amount of any additional Notes purchased by the Underwriters pursuant to the exercise of their over-allotment option as set forth in the Underwriting Agreement), [in accordance with the rules and procedures of the
Depositary,]5 on July 1, 2019, and interest thereon
as set forth below. 
 This Note shall bear interest at the rate of 4.00% per year from June 25, 2012, or from the
most recent date to which interest had been paid or provided for to, but excluding, the next scheduled Interest Payment Date until July 1, 2019. Accrued interest on this Note shall be computed on the basis of a 360-day year composed of twelve
30-day months. Interest is payable semi-annually in arrears on each January 1 and July 1, commencing on January 1, 2013, to Holders of record of the Notes at the close of business on the preceding December 15 and June 15
(whether or not such day is a Business Day), respectively. Additional Interest may be payable as set forth in Section 6.02 of the Supplemental Indenture, and any reference to interest on, or in respect of, any Note therein shall be deemed to
include Additional Interest if, in such context, Additional Interest is, was or would be payable pursuant to such Section 6.02 and any express mention of the payment of Additional Interest in any provision therein shall not be construed as
excluding Additional Interest in those provisions thereof where such express mention is not made. 
 [The Issuer shall pay the
principal of and interest on this Note, so long as such Note is a Global Security, in immediately available funds to the Depositary or its nominee, as the case may be, as the registered Holder of such Note.]6 As provided in and subject to the provisions of 

 

	 	1 	Include for Global Security. 

  

	 	2 	Include for certificated Note. 

  

	 	3 	Include for Global Security. 

  

	 	4 	 Include for certificated Note. 

  

	 	5 	Include for Global Security. 

  

	 	6 	 Include for Global Security. 

  
 A-2

 
the Indenture, the Issuer shall pay the principal of any Notes (other than Notes that are Global Securities) at the office or agency designated by the Issuer for that purpose. The Issuer has
initially designated the Trustee as its paying agent and Registrar in respect of the Notes and its agency at its Corporate Trust Office designated pursuant to Section 3.02 of the Base Indenture (as defined below) as a place where Notes may be
presented for payment or for registration of transfer. 
 Reference is made to the further provisions of this Note set forth on
the reverse hereof, including, without limitation, provisions giving the Holder of this Note the right to convert this Note into shares of Common Stock on the terms and subject to the limitations set forth in the Indenture. Such further provisions
shall for all purposes have the same effect as though fully set forth at this place. 
 This Note shall be governed by and
construed in accordance with the laws of the State of New York. 
 In the case of any conflict between this Note and the
Indenture, the provisions of the Indenture shall control and govern. 
 This Note shall not be valid or become obligatory for
any purpose until the certificate of authentication hereon shall have been manually signed by the Trustee or a duly authorized authenticating agent under the Indenture. 
 [Remainder of page intentionally left blank] 

  
 A-3

 IN WITNESS WHEREOF, the Issuer has caused this Note to be duly executed. 

 

			
	AFFYMETRIX, INC.
		
	By:	 	 
		 	 Name:

Title:

 Dated: 

TRUSTEE’S CERTIFICATE OF AUTHENTICATION 

This is one of the Securities of the series designated therein referred to in the within-mentioned Indenture. 

 

			
	 THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A.,

as Trustee

		
	By:	 	 
		 	Authorized Signatory

  
 A-4

 [FORM OF REVERSE OF NOTE] 

AFFYMETRIX, INC. 

4.00% Convertible Senior Note due 2019 
 This Note is one of a duly authorized series of Securities of the Issuer, designated as its 4.00% Convertible Senior Notes due 2019 (the “Notes”), limited to the aggregate principal
amount of $105,000,000 (as increased by an amount equal to the aggregate principal amount of any additional Notes purchased by the Underwriters pursuant to the exercise of their over-allotment option as set forth in the Underwriting Agreement) all
issued or to be issued under and pursuant to an Indenture dated as of June 25, 2012 (the “Base Indenture”), as amended and supplemented by the First Supplemental Indenture dated as of June 25, 2012 (herein called the
“Supplemental Indenture”; the Base Indenture, as amended and supplemented by the Supplemental Indenture, and as it may be further amended or supplemented from time to time, the “Indenture”), by and between the
Issuer and The Bank of New York Mellon Trust Company, N.A. (the “Trustee”) to which Indenture and all indentures supplemental thereto reference is hereby made for a description of the rights, limitations of rights, obligations,
duties and immunities thereunder of the Trustee, the Issuer and the Holders of the Notes. Additional Notes may be issued in an unlimited aggregate principal amount, subject to the conditions specified in the Indenture. 

Subject to the terms and conditions of the Indenture, the Issuer will make all payments and deliveries in respect of any redemption
price, the Fundamental Change Repurchase Price and the principal amount on the Maturity Date, as the case may be, to the Holder who surrenders a Note to a paying agent to collect such payments in respect of the Note. The Issuer shall pay cash
amounts in money of the United States that at the time of payment is legal tender for payment of public and private debts. 
 No
reference herein to the Indenture and no provision of this Note or of the Indenture shall alter or impair the obligation of the Issuer, which is absolute and unconditional, to pay the principal (including the Fundamental Change Repurchase Price, if
applicable) of, the redemption price, if applicable, of, and accrued and unpaid interest on, and the consideration due upon conversion of, this Note at the place, at the respective times, in the amounts and, if applicable, in the lawful money herein
prescribed. 
 The Notes are issuable in registered form without coupons in denominations of $1,000 principal amount and
multiples thereof. At the office or agency of the Issuer referred to on the face hereof, and in the manner and subject to the limitations provided in the Indenture, Notes may be exchanged for a like aggregate principal amount of Notes of other
authorized denominations, without payment of any service charge but, if required by the Issuer or Trustee, with payment of a sum sufficient to cover any transfer tax or similar governmental charge required by law or that may be imposed in connection
therewith as a result of the name of the Holder of the new Notes issued upon such exchange of Notes being different from the name of the Holder of the old Notes surrendered for such exchange. 

The Notes shall be redeemable at the Issuer’s option in accordance with the terms and conditions specified in the Indenture.

  
 A-5

 Upon the occurrence of a Fundamental Change, the Holder has the right, at such Holder’s
option, to require the Issuer to repurchase for cash all of such Holder’s Notes or any portion thereof (in principal amounts of $1,000 or multiples thereof) on the Fundamental Change Repurchase Date at a price equal to the Fundamental Change
Repurchase Price. 
 Subject to the provisions of the Indenture, the Holder hereof has the right, at its option, prior to the
close of business on the Business Day immediately preceding the Maturity Date, to irrevocably convert any Notes or portion thereof that is $1,000 or a multiple thereof into shares of Common Stock at the Conversion Rate specified in the Indenture, as
adjusted from time to time as provided in the Indenture, unless the Issuer has called Notes for redemption, in which case the Holder may convert such Notes until the close of business on the Scheduled Trading Day immediately preceding the applicable
redemption date. 
 Terms used in this Note and defined in the Indenture are used herein as therein defined. 

  
 A-6

 ABBREVIATIONS 
 The following abbreviations, when used in the inscription of the face of this Note, shall be construed as though they were written out in full according to applicable laws or regulations: 

TEN COM = as tenants in common 
 UNIF GIFT MIN
ACT = Uniform Gifts to Minors Act 
 CUST = Custodian 
 TEN ENT = as tenants by the entireties 
 JT TEN = joint tenants with right of survivorship and not
as tenants in common 
 Additional abbreviations may also be used though not in the above list. 

  
 A-7

 SCHEDULE A 

SCHEDULE OF EXCHANGES OF NOTES7 
 AFFYMETRIX, INC. 
 4.00% Convertible Senior Notes due 2019 

The initial principal amount of this Global Security is
[                    ] DOLLARS
($[                    ]). The following increases or decreases in this Global Security have been made: 

 

									
	 Date of Exchange
	  	 Amount of

decrease in

Principal Amount

of this Global

Security
	  	 Amount of

increase in

Principal Amount

of this Global

Security
	  	 Principal Amount

of this Global

Security following

such decrease or

increase
	  	 Signature of

authorized

signatory of

Trustee or Note

Custodian

					
	  
	  	  
	  	  
	  	  
	  	  

					
	  
	  	  
	  	  
	  	  
	  	  

					
	  
	  	  
	  	  
	  	  
	  	  

					
	  
	  	  
	  	  
	  	  
	  	  

					
	  
	  	  
	  	  
	  	  
	  	  

					
	  
	  	  
	  	  
	  	  
	  	  

					
	  
	  	  
	  	  
	  	  
	  	  

					
	  
	  	  
	  	  
	  	  
	  	  

					
	  
	  	  
	  	  
	  	  
	  	  

					
	  
	  	  
	  	  
	  	  
	  	  

					
	  
	  	  
	  	  
	  	  
	  	  

					
	  
	  	  
	  	  
	  	  
	  	  

					
	  
	  	  
	  	  
	  	  
	  	  

					
	  
	  	  
	  	  
	  	  
	  	  

					
	  
	  	  
	  	  
	  	  
	  	  

					
	  
	  	  
	  	  
	  	  
	  	  

					
	  
	  	  
	  	  
	  	  
	  	  

					
	  
	  	  
	  	  
	  	  
	  	  

					
	  
	  	  
	  	  
	  	  
	  	  

					
	  
	  	  
	  	  
	  	  
	  	  

					
	  
	  	  
	  	  
	  	  
	  	  

					
	  
	  	  
	  	  
	  	  
	  	  

					
	  
	  	  
	  	  
	  	  
	  	  

					
	  
	  	  
	  	  
	  	  
	  	  

					
	  
	  	  
	  	  
	  	  
	  	  

  
  

	 	7 	 Include for Global Security. 

  
 A-8

 ATTACHMENT 1 

[FORM OF NOTICE OF CONVERSION]8 
 To:
Affymetrix, Inc. 
 The undersigned registered owner of this Note hereby exercises the option to convert this Note, or the
portion hereof (that is $1,000 principal amount or a multiple thereof) below designated, into shares of Common Stock in accordance with the terms of the Indenture referred to in this Note, and directs that the shares of Common Stock issuable and
deliverable upon such conversion, together with any cash for any fractional share of Common Stock, and any Notes representing any unconverted principal amount hereof, be issued and delivered to the registered Holder of the Notes hereof unless a
different name has been indicated below. If any shares of Common Stock or any portion of this Note not converted are to be issued in the name of a Person other than the undersigned, the undersigned will pay all transfer taxes or similar governmental
charges in accordance with Section 8.02(d) of the Supplemental Indenture. Any amount required to be paid to the undersigned on account of interest accompanies this Note. 

 

							
				
	Dated:	 	 	 		 	 
				
		 		 		 	 
		 		 		 	Signature(s)
			
	 	 		 	
	Signature Guarantee	 		 	
			
	 Signature(s) must be guaranteed
 by an eligible Guarantor Institution
 (banks, stock brokers, savings and

loan associations and credit unions)
 with
membership in an approved
 signature guarantee medallion program
 pursuant to Securities and Exchange
 Commission Rule 17Ad-15 if

shares of Common Stock are to be issued, or

Notes are to be delivered, other than
 to and in
the name of the registered holder.
  
 Fill in for registration of shares
if
 to be issued, and Notes if to
	 		 	

  
  

	 	8 	 Include for certificated Note. 

  
 1 

							
	 be delivered, other than to and in the
 name of the registered holder:
	 		 	
			
	 	 		 	
	(Name)	 		 	
			
	 	 		 	
	(Street Address)	 		 	
			
	 	 		 	
	 (City, State and Zip Code)
 Please print name and address
	 		 	
			
		 		 	 Principal amount to be converted (if less than all):
 $            ,000
  
 NOTICE: The above signature(s) of the Holder(s) hereof
 must correspond with the name as written
upon the face of
 the Note in every particular without alteration or
 enlargement or any change whatever.

				
		 		 		 	 
		 		 		 	 Social Security or Other Taxpayer
 Identification Number

  
 2 

 ATTACHMENT 2 

[FORM OF FUNDAMENTAL CHANGE REPURCHASE NOTICE]9 
 To:
Affymetrix, Inc. 
 The undersigned registered owner of this Note hereby acknowledges receipt of a notice from Affymetrix, Inc.
(the “Issuer”) as to the occurrence of a Fundamental Change with respect to the Issuer and specifying the Fundamental Change Repurchase Date and requests and instructs the Issuer to pay to the registered holder hereof in accordance
with the applicable provisions of the Indenture referred to in this Note (1) the entire principal amount of this Note, or the portion thereof (that is $1,000 principal amount or a multiple thereof) below designated, and (2) if such
Fundamental Change Repurchase Date does not fall during the period after a Regular Record Date and on or prior to the corresponding Interest Payment Date, accrued and unpaid interest, if any, thereon to, but excluding, such Fundamental Change
Repurchase Date. 
 In the case of certificated Notes, the certificate numbers of the Notes to be repurchased are as set forth
below: 
  

							
				
	Dated:	 	 	 		 	
				
		 		 		 	 
		 		 		 	Signature(s)
			
		 		 	 
		 		 	 Social Security or Other Taxpayer
 Identification Number
  

Principal amount to be repurchased (if less than all):
 $            ,000

 NOTICE: The above signature(s) of the Holder(s) hereof must correspond with the name as written upon the face of the Note
in every particular without alteration or enlargement or any change whatever. 
  

 

	 	9 	 Include for certificated Note. 

  
 1 

 ATTACHMENT 3 

[FORM OF ASSIGNMENT AND TRANSFER]10 
 For value
received                      hereby sell(s), assign(s) and transfer(s) unto
                     (Please insert Social Security or Taxpayer Identification Number of assignee) the within Note, and hereby irrevocably
constitutes and appoints                      attorney to transfer the said Note on the books of the Issuer, with full power of substitution in the
premises. 
  

							
				
		 		 		 	
				
		 		 		 	 
			
		 		 	 
		 		 	 Signature(s)
  

Signature(s) must be guaranteed by an institution which is a member of one of the following recognized signature Guarantee Programs:

 
 (i) The Securities Transfer Agent Medallion Program (STAMP); (ii) The New York
Stock Exchange Medallion Program (MNSP); (iii) The Stock Exchange Medallion Program (SEMP) or (iv) another guarantee program acceptable to the Trustee.

				
		 		 		 	 
			
		 		 	 
		 		 		 	Signature Guarantee

  
  

	 	10 	 Include for certificated Note. 

  
 1

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