Document:

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eResearchTechnology
Enabling the Clincial Advantage
A Wholly Owned Subsidiary of Premier Research Worldwide, Ltd

                         MANAGEMENT EMPLOYMENT AGREEMENT

The following agreement is hereby entered into between Robert Brown (hereinafter
known as Employee) and eResearchTechnology (together with its affiliated
corporations hereinafter known as the "Company") and having its principal
offices at 30 S. 17th Street, Philadelphia, PA 19103

1.       DUTIES AND RESPONSIBILITIES

         Employee agrees to hold the position of Sr. VP Diagnostic Technology
         and Services and shall be directly responsible to President and CEO.

2.       BEST EFFORTS

         Employee agrees to devote his best efforts to his employment with the
         Company, on a full-time (no less than 40 hours/week) basis. He further
         agrees not to use the facilities, personnel or property of the Company
         for personal or private business benefit.

3.       ETHICAL CONDUCT

         Employee will conduct himself in a professional and ethical manner at
         all times and will comply with all company policies as well as all
         State and Federal regulations and laws as they may apply to the
         services, products, and business of the Company.

4.       TERM OF THE AGREEMENT

         This agreement will be for a period of one year, commencing January 1,
         2000 and will continue from year to year unless terminated.

5.       COMPENSATION

          a.   Salary shall be $150,000/year payable in equal installments as
               per the company's payroll policy. Salary shall be considered on
               an annual basis and adjusted based on performance.

          b.   Benefits shall be the standard benefits of the Company as they
               shall exist from time to time.

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          c.   Annual bonus, based upon achieving 100% of targeted corporate and
               department goals to be defined, of $100,000. (60% of the
               department bonus will be payable quarterly in four (4) equal
               installments and 40% payable annually based on corporate
               performance.)

          d.   Draw of $3,000 per month, for one year, against
               commissions/bonuses earned. In the event draw balance is greater
               than zero at the end of fiscal year, it will automatically revert
               to zero.

          e.   Car allowance of $500 per month.

6.       NON-DISCLOSURE

         Employee acknowledges that employment with the Company requires him/her
         to have access to confidential information and material belonging to
         the Company, including customer lists, contracts, proposals, operating
         procedures, trade secrets and business methods and systems, which have
         been developed at great expense by the Company and which Employee
         recognizes to be unique assets of the Company's business. Upon
         termination of employment for any reason, Employee agrees to return to
         the Company any such confidential information and material in his
         possession with no copies thereof retained. Employee further agrees,
         whether during employment with the Company or any time after the
         termination thereof (regardless of the reason for such termination), he
         will not disclose nor use in any manner, any confidential or
         proprietary material relating to the business, operations, or prospects
         of the Company except as authorized in writing by the Company or
         required during the performance of his duties.

7.       BUSINESS INTERFERENCE; NONCOMPETITION

          a.   During employment with the Company and for a period of one year
               (the "Restrictive Period") thereafter (regardless of the reason
               for termination) Employee agrees he will not, directly or
               indirectly, in any way for his own account, as employee,
               stockholder, partner, or otherwise, or for the account of any
               other person, corporation, or entity: (i) request or cause any of
               the Company's suppliers, customers or vendors to cancel or
               terminate any existing or continuing business relationship with
               the Company; (ii) solicit, entice, persuade, induce, request or
               otherwise cause any employee, officer or agent of the Company to
               refrain from rendering services to the Company or to terminate
               his or her relationship, contractual or otherwise, with the
               Company; or (iii) induce or attempt to influence any customer or
               vendor to cease or refrain from doing business or to decline to
               do business with the Company or any of its affiliated
               distributors or vendors.

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          b.   The Employee agrees that, during the Restrictive Period, the
               Employee will not, directly or indirectly, accept employment
               with, provide services to or consult with, or establish or
               acquire any interest in, any business, firm, person, partnership,
               corporation or other entity which engages in any business or
               activity that is the same as or competitive with the business
               conducted by the Company in any state of the United States of
               America and in any foreign country in which any customer to whom
               the Company is providing services or technology is located.

8.       FORFEITURE FOR BREACH; INJUNCTIVE RELIEF.

          a.   Any breach of the covenants made in Sections 6 and 7 hereof shall
               result in the forfeiture of the Employee's right to any and all
               payments which may be required to be made under this Agreement
               following such breach and shall relieve the Company of any
               obligation to make such payments.

          b.   The Employee acknowledges that his compliance with the covenants
               in Sections 6 and 7 hereof is necessary to protect the good will
               and other proprietary interests of the Company and that, in the
               event of any violation by the Employee of the provisions of
               Section 6 or 7 hereof, the Company will sustain serious,
               irreparable and substantial harm to its business, the extent of
               which will be difficult to determine and impossible to remedy by
               an action at law for money damages. Accordingly, the Employee
               agrees that, in the event of such violation or threatened
               violation by the Employee, the Company shall be entitle to an
               injunction before trial from any court of competent jurisdiction
               as a matter of course and upon the posting of not more than a
               nominal bond in addition to all such other legal and equitable
               remedies as may be available to the Company.

          c.   The rights and remedies of the Company as provided in this
               Section 8 shall be cumulative and concurrent and may be pursued
               separately, successively or together against Employee, at the
               sole discretion of the Company, and may be exercised as often as
               occasion therefor shall arise. The failure to exercise any right
               or remedy shall in no event be construed as a waiver or release
               thereof.

          d.   The Employee agrees to reimburse the Company for any expenses
               incurred by it in enforcing the provisions of Sections 6 and 7
               hereof if the Company prevails in that enforcement.

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9.       INVENTIONS

         Employee agrees to promptly disclose to the Company each discovery,
         improvement, or invention conceived, made, or reduced to practice
         (whether during working hours or otherwise) during the term of
         employment. Employee agrees to grant to the Company the entire interest
         in all of such discoveries, improvements, and inventions and to sign
         all patent/copyright applications or other documents needed to
         implement the provisions of this paragraph without additional
         consideration. Employee further agrees that all works of authorship
         subject to statutory copyright protection developed jointly or solely,
         while employed shall be considered a work made for hire and any
         copyright thereon shall belong to the Company. Any invention,
         discovery, or improvement conceived, made, or disclosed, during the one
         year period following the termination of employment with the Company
         shall be deemed to have been made, conceived, or discovered during
         employment with the Company.

         Employee acknowledges that the only discoveries, improvements, and
         other inventions made prior to the date hereof which have not been
         filed in the United States Patent Office are attached as Exhibit A.

10.      NO CURRENT CONFLICT

         Employee hereby assures the Company that he is not currently restricted
         by any existing employment or non-compete agreement that would conflict
         with the terms of this Agreement.

11.      TERM; TERMINATION AND TERMINATION BENEFITS

          a.   Employment is "at will" which means that either the Company or
               Employee may terminate at any time, with or without cause or good
               reason, upon written notice given at least 30 days prior to
               termination.

          b.   This Agreement shall terminate upon the death of the Employee. In
               addition, if, as a result of a mental or physical condition
               which, in the reasonable opinion of a medical doctor selected by
               the Company's board of directors, can be expected to be permanent
               or to be of an indefinite duration and which renders the Employee
               unable to carry out the job responsibilities held by, or the
               tasks assigned to, the Employee immediately prior to the time the
               disabling condition was incurred, or which entitles the Employee
               to receive disability payments under any long-term disability
               insurance policy which covers the Employee for which the premiums
               are reimbursed by the Company (a "Disability"), the Employee
               shall have been absent from his duties hereunder on a full-time
               basis for 120 consecutive days, or 180 days

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               during any twelve month period, and within thirty (30) days after
               written notice (which may occur before or after the end of such
               120 or 180 day period), by the Company to Employee of the
               Company's intent to terminate the Employee's employment by reason
               of such Disability, the Employee shall not have returned to the
               performance of his duties hereunder, the Employee's employment
               hereunder shall, without further notice, terminate at the end of
               said thirty-day notice.

          c.   The Company may also terminate the Employee's employment under
               this Agreement for Cause. For purposes of this Agreement the
               Company shall have "Cause" to terminate the Employee's employment
               if the Employee, in the reasonable judgment of the Company, (i)
               fails to perform any reasonable directive of the Company that may
               be given from time to time for the conduct of the Company's
               business; (ii) materially breaches any of his commitments, duties
               or obligations under this Agreement; (iii) embezzles or converts
               to his own use any funds of the Company or its Affiliates or any
               business opportunity of the Company of its Affiliates; (iv)
               destroys or converts to his own use any property of the Company
               or its Affiliates, without the Company's consent; (v) is
               convicted of, or indicted for, or enters a guilty plea or plea of
               no contest with respect to, a felony; (vi) is adjudicated an
               incompetent or (vii) violates any federal, state, local or other
               law applicable to the business of the Company or engages in any
               conduct which, in the reasonable judgment of the Company, is
               injurious to the business or interests of the Company.

          d.   Upon any termination of this Agreement, the Company shall have no
               further obligation to Employee other than for Annual Salary
               earned through the date of termination, and no severance pay or
               other benefits of any kind shall be payable; provided, however,
               that in the event the Company terminates this Agreement other
               than for Cause or as a result of the death or Disability of the
               Employee, the company will provide for a six months severance
               package which will include base salary and benefits. The Company
               must give the Employee written notice of the Employee's breach
               under sections 11.c.(I), and 11.c.(ii), and 11.c.(Vii) and 15
               days to cure before the Employee is given notice of termination
               as required under Section 11.1a

          e.   Notwithstanding any contrary provision contained in this
               Employment Agreement, in the event that either (a) there is a
               "Change of Control" (as hereafter defined) and neither the
               Company nor the Buyer offers the Executive a position with
               comparable responsibilities, authority, location or compensation,
               or (b) after the date of the Change in Control but before the
               first anniversary thereof, the Executive's responsibilities,
               authority, location, or compensation are not acceptable to the
               Executive the Executive may elect to resign and receive severance
               equal to six month's annual salary and applicable prorated bonus,
               hereunder, payable in one lump sum in accordance with the
               Company's policy.

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               In addition, the Executive will continue to receive (subject to
               payment of any applicable premium co-pay) standard health,
               dental, disability, life and accident insurance benefits for the
               six month period following the termination of employment.

               The Executive must provide written notice of such election not
               less than sixty days following the date of the Change of Control
               or, if the Executive's new position is changed within the time
               period and in the manner described above, within thirty days
               following such event.

               The term "Change of Control", as utilized herein, refers to:

                      (i)    A change of control of a nature that would be
                             required to be reported in the Company's proxy
                             statement under the Securities Exchange Act of
                             1934, as amended;

                      (ii)   The approval by the Board of Directors of a sale,
                             not in the ordinary course of business, of all or
                             substantially all of the Company's assets and
                             business to an unrelated third party and the
                             consummation of such transaction; or

                      (iii)  The approval by the Board of Directors of any
                             merger, consolidation, or like business combination
                             or reorganization of the Company, the consummation
                             of which would result in the occurrence of any
                             event described in clause (i) or (ii) above, and
                             the consummation of such transaction.

         Except as expressly modified and amended hereby, the Employment
         Agreement and its terms and provisions are hereby ratified, confirmed
         and approved in all respects.

12.      MISCELLANEOUS

          a.   This Agreement and any disputes arising herefrom shall be
               governed by Pennsylvania law.

          b.   In the event that any provision of this Agreement is held to be
               invalid or unenforceable for any reason, including without
               limitation the geographic or business scope or duration thereof,
               this Agreement shall be construed as if such provision had been
               more narrowly drawn so as not to be invalid or unenforceable.

          c.   This Agreement supersedes all prior agreements, arrangements, and
               understandings, written or oral, relating to the subject matter.

          d.   The failure of either party at any time or times to require
               performance of any provision hereof shall in no way affect the
               right at a later time to enforce the same. No waiver by either
               party of any condition or of the breach by the other of any
               term or covenant contained in this

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               Agreement shall be effective unless in writing and signed by the
               aggrieved party. A waiver by a party hereto in any one or more
               instances shall not be deemed or construed as a further or
               continuing waiver of any such condition or breach or a waiver of
               any other condition, or of the breach of any other term or
               covenant set forth in this Agreement.

          e.   Any notice required or permitted to be given under this Agreement
               shall be in writing and shall be deemed to have been given when
               delivered in person, sent by certified mail, postage prepaid, or
               delivered by a nationally recognized overnight delivery service
               addressed, if to the Company at 30 S. 17th Street, 8th Floor,
               Philadelphia, PA 19103 Attn: President and if to the Employee, at
               the address of his personal residence as maintained in the
               Company's records.

For Employee:                                     For the Company:

/s/ Robert Brown                                  /s/ Joseph Esposito
-----------------------------                     ------------------------------
    Robert Brown                                      Joseph Esposito

Date: 1/1/00                                      Date: 1/1/00
     ------------------------                     ------------------------------

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                         MANAGEMENT EMPLOYMENT AGREEMENT
                                    AMENDMENT

         This Amendment (this "Amendment") to Management Employment Agreement
dated January 1, 2000 is made this 8th day of August, 2000 between
eResearchTechnology, Inc. ("Company") and Robert Brown ("Employee").

                                   BACKGROUND:

         Company and Employee are parties to a certain Management Employment
Agreement dated January 1, 2000 (the "Agreement"). Company and Employee now
desire to amend certain provisions of the Agreement as set forth in this
Amendment.

         Capitalized terms used but not defined herein shall have the meanings
given to them in the Agreement.

         NOW, THEREFORE, Company and Employee, each intending to be legally
bound hereby, agree as follows:

1.       The Agreement is hereby amended as follows:

         1.1      Section 5(c) is hereby amended and restated to read in its
entirety as follows:

         "Annual bonus, based upon achieving 100% of targeted corporate and
department goals to be defined, of $100,000."

2.       Miscellaneous

         2.1 All references to the Agreement in any documents and instruments
executed by the parties in connection with the Agreement shall be deemed to
refer to the Agreement as the same has been amended through the date hereof, and
as the same may be amended in the future.

         2.2 This Amendment may be executed in any number of counterparts and
each such counterpart shall be deemed an original, but all such counterparts
shall constitute but one and the same agreement.

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         2.3 The Agreement and this Amendment may be modified or amended by the
parties hereto only by a written agreement executed by both parties.

         2.4 Except as expressly amended hereby, all of the terms and provisions
of the Agreement shall remain in full force and effect and are hereby ratified
and confirmed in every respect.

         2.5 This Amendment shall be governed by and construed in accordance
with the internal laws of the Commonwealth of Pennsylvania, without regard to
conflicts of laws principles.

         IN WITNESS WHEREOF, the undersigned have caused this Amendment to be
executed on the date first written above.

                                     ERESEARCHTECHOLOGY, INC.

                                     By: /s/ Bruce Johnson
                                         -------------------------------
                                         Name:  Bruce Johnson
                                         Title:  Sr. VP, Chief Financial Officer

                                     /s/  Robert Brown
                                     -----------------------------------
                                     Robert Brown<PAGE>

                         SERVICES AND SUPPORT AGREEMENT

         This Services and Support Agreement (the "Agreement") is made as of the
1st day of January, 2000 by and between Premier Research Worldwide, Ltd., a
Delaware corporation ("Premier") and eResearch Technology, Inc., a Delaware
corporation ("eRT").

         WHEREAS, Premier owns 100% of the outstanding capital stock of eRT; and

         WHEREAS, Premier has contributed to eRT all of Premier's technology and
operating business subject to the liabilities thereof; and

         WHEREAS, the parties recognize that it is to their material advantage
to centralize certain administrative and financial services and that such
centralized services will be most efficiently administered by eRT.

         NOW, THEREFORE, is consideration of the premises and the mutual
covenants contained herein, and intending to be legally bound, the parties
hereto agree as follows:

         1. Services to Be Provided by eRT. Beginning on the date of this
Agreement, eRT through its corporate staff will provide or otherwise make
available to Premier certain general corporate services, including, but not
limited to the following:

                  1.1 Management Support. eRT will provide management support to
Premier, including reasonable access to key management personnel of eRT for
consultation and advice regarding strategic business planning, corporate
development, acquisitions and technology. eRT will also provide assistance to
develop and implement policies and procedures related to human resources and
employee training.

                  1.2 Risk Management. eRT will assist Premier in the
maintenance of an appropriate risk management program. eRT shall arrange for and
pay the premium cost of liability, property, casualty, and other normal business
insurance coverage (subject to allocation of such premium pursuant to Section
6.2 hereof), provide a centralized insurance purchasing service for such
insurance coverage and manage all insurance claims under Premier's insurance
policies.

                  1.3  Financial Services. eRT shall provide to Premier the
financial services listed in Exhibit I to this Agreement.

                  1.4 Securities. eRT will provide services and assistance to
enable Premier to comply with its reporting obligations under the Securities
Exchange Act of 1934 (the "1934 Act"), and the rules and regulations of the
Nasdaq Stock Market. Such assistance will include preparation of Forms 10-K,
10-Q and 8-K under the 1934 Act. eRT will provide necessary

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resources to enable Premier to make EDGAR filings with the SEC. eRT shall
provide internal audit support services for such filings and reports, including
accounting staff as required. Accounting and financial reporting policies and
procedures will be established by the Chief Financial Officer of eRT (the "eRT
CFO"). The parties acknowledge that Premier is a reporting company under the
1934 Act and that eRT may in the future become such a reporting company. Because
of eRT's status as a wholly-owned subsidiary of eRT, the parties also
acknowledge that each party has a material interest in the financial statements
and reports of the other to insure that accounting matters are treated
consistently between the parties. Therefore, before financial statements of
either party are released publicly or are included in a filing with the SEC or
the Nasdaq Stock Market, such financial statements will be furnished to the eRT
CFO and to Premier's Chief Financial Officer for review and comment. All public
releases of financial information will be authorized in advance by both parties'
Chief Financial Officer. eRT will administer a program to promote compliance by
the officers and directors of Premier with their reporting requirements under
Section 13 and 16 of the 1934 Act. eRT shall prepare documents necessary for
officer and director compliance under Section 16 of the 1934 Act, including
Forms 3, 4, 5, 13G and 13D. eRT shall maintain detailed records and SEC receipts
of all such filings and shall administer periodic reminders to Section 16
officers and directors. eRT shall periodically provide information to officers
and directors of Premier with respect to their responsibilities under Section 16
of the Act.

                  1.5 Corporate Record Keeping. eRT shall maintain detailed
records of Premier's historical and current financial data. In addition, eRT
shall assist in preparing the minutes of meetings of the boards of directors and
shareholders, and shall maintain records pertaining to stock offerings,
acquisition transactions, and annual meetings.

                  1.6 Annual Stockholders Meetings and Proxy Statement
Preparation. eRT shall provide assistance to conduct the annual meeting of
Premier stockholders. eRT shall assist in the preparation of the notice of the
annual meeting, proxies and proxy statements related thereto, the solicitation
of proxies, and the filing of any preliminary or definitive proxy statements
with the SEC. eRT shall assist Premier in design, preparation, drafting and
distribution of its annual reports to stockholders. Preparation and distribution
costs related to the proxy materials for the annual meeting shall be paid by
Premier.

                  1.7 Stock Plan Administration Services. Subject to the
direction of the administrative committees of Premier compensation stock plans,
shall administer Premier's stock option plans. eRT shall maintain records of
grant dates, shares covered by option grants, vesting schedules, expiration
dates and other information necessary for proper administration of the Premier
compensatory stock plans. eRT shall also prepare stock option grant agreements
and stock option exercise notices.

                  1.8 Investor and Media Relations. eRT shall prepare quarterly
stock reports, track outstanding shares, communicate appropriate information to
transfer agents, provide for missing stock certificates and perform general
services pertaining to the investor relations. eRT shall upon request provide
stock status reports including stockholder statistics, earnings

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estimates, shares held by institutions and any other reports that can be
reasonably created using Premier data maintained by eRT. eRT shall assist
Premier to manage investor and media relations and to prepare press releases.
eRT shall assist Premier in its relationship with investment analysts and
institutional holders of Premier stock. eRT will also assist eRT regarding
presentations at financial conferences.

                  1.9  Tax Matters. eRT will assist Premier to prepare and file
state and federal income tax returns and will consult with Premier regarding tax
planning matters.

                  1.10 Other Services. Other routine services in addition to
those enumerated in subsections 1.1 through 1.9 shall be provided by eRT as
reasonably requested by Premier. Such other services shall include human
resources support, publications support, corporate training programs, video
teleconferencing, data and voice communications and trade show support.

         2. Cooperation. Premier shall corporate with eRT in providing
information and data reasonably requested by eRT to perform its services
hereunder. The parties shall exert best efforts to coordinate with each other in
such a manner to enable eRT to furnish the services required hereunder.

         3. Credit Support Services. Premier agrees to provide credit support
for eRT as eRT may reasonably require for its business and operations, subject
to a maximum financial commitment by Premier to eRT at any time of $10 million.
eRT shall reconcile on a quarterly basis cash provided by Premier and used by
eRT and shall calculate an average daily balance for such advances during each
such quarter. eRT shall be obligated to repay all such advances together with
interest on the average daily balance for each quarterly period at the prime
rate of interest as published from time to time in The Wall Street Journal.

         4. Transition Support Services. Premier agrees to allow eRT to use
Premier's bank accounts and financial management and other administrative
services and systems for a reasonable period following the effective date of
this Agreement for eRT's own cash management and financial services
requirements. eRT shall use reasonable commercial efforts to establish such
accounts and systems for itself as promptly a practicable after the date hereof.

         5. Insurance Programs. The parties acknowledge that Premier has in
force insurance programs that provide eRT coverage under general liability,
property and casualty, errors and omissions, umbrella liability, workers'
compensation, directors and officers liability and medical and other employee
benefit insurance programs. eRT shall evaluate the merits of having such
insurance policies transferred to eRT, continuing eRT's cover under the current
Premier programs or obtaining separate coverage for eRT. Pending such
determination, Premier agrees that eRT shall continue maintaining such coverage
in accordance with the provisions of Section 1.2 hereof for the benefit of both
Premier and eRT, subject to allocation of premiums therefor in accordance with
Section 6.2 hereof.

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         6. Compensation for Services.

                  6.1 In consideration for the services to be provided by eRT to
Premier hereunder, Premier shall provide the credit support and transition
support services specified in Section 3-4 hereof and shall pay eRT the following
amounts:

                           (a)      6.25% of the salary of eRT's President and
Chief Executive Officer;

                           (b)      25% of the salary of eRT's Chief Financial
Officer; and

                           (c)      a fee of $10,000 per month.

eRT shall invoice Premier monthly for such charges.

                  6.2 For any period during the term hereof that eRT is included
in any Premier insurance programs or policies, eRT's Chief Financial Officer
shall recommend an allocation of the premium between eRT and Premier, which
allocation shall be subject to review and approval by the Boards of Directors of
each party or any authorized committee thereof. Promptly after agreement on such
allocation, eRT shall prepare an invoice from Premier to eRT for eRT's allocated
portion of such premiums.

                  6.3 All invoices delivered hereunder shall be due and payable
within 30 days of the invoice date.

                  6.4 In the event eRT is required to commit personnel on other
resources in the performance of its obligations hereunder that are
disproportionate to the projected fees set forth in Section 6.1 hereof, the
parties agree to negotiate in good faith to adjust the monthly fee payable
pursuant to Section 6.1(c) hereof or to consider in good faith payment by
Premier to eRT of a supplemental fee in addition to the scheduled monthly fee.

                  6.5 eRT will require third parties with which it contracts on
behalf of Premier hereunder, including without limitation accounting, legal and
other professional service firms, insurance companies and other vendors, to
invoice Premier for their respective charges. Premier acknowledges and agrees
that eRT will cause such invoices to be paid on Premier's behalf in accordance
with the invoice terms.

         7.  Office Space. eRT agrees to make available appropriate office space
to Premier's Chairman and Chief Executive Officer.

         8. Premier's Directors and Officers. Nothing contained herein will be
construed to relieve the directors and officers of Premier from the performance
of their respective duties or to limit the exercise of their powers in
accordance with the charter or by-laws of Premier or in accordance with any
applicable statute or regulation.

                                      - 4 -

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         9. Liabilities. In furnishing Premier with management advice and other
services as herein provided, neither eRT nor any of its officers, directors or
agents shall be liable to Premier or its creditors or shareholders for errors of
judgment or for anything except willful malfeasance, bad faith or gross
negligence in the performance of their duties or reckless disregard of their
obligations and duties under the terms of this Agreement. The provisions of this
Agreement are for the sole benefit of Premier and eRT and will not, except to
the extent otherwise expressly stated herein, inure to the benefit of any third
party.

         10. Status. eRT shall be deemed to be an independent contractor, and
except as expressly provided or authorized in this Agreement, shall have no
authority to act for or represent Premier.

         11. Notices. All notices, billings, requests, demands, approvals,
consents, and other communications which are required or may be given under this
Agreement shall be in writing and will be deemed to have been duly given if
delivered personally or sent by registered or certified mail, return receipt
requested, postage prepaid to the parties at their respective addresses set
forth below:

                  If to Premier:

                           Premier Research Worldwide, Ltd.
                           30 South 17th Street
                           Philadelphia, PA  19103
                           Attention:  Chairman

                  If to eRT:

                           eResearch Technology, Inc.
                           30 South 17th Street
                           Philadelphia, PA  19103
                           Attention:  President and Chief Executive Officer

         12. No Assignment. This Agreement shall not be assignable except with
the prior written consent of the other party to this Agreement.

         13. Applicable Law. This Agreement shall be governed by and construed
under the laws of the Commonwealth of Pennsylvania applicable to contracts made
and to be performed therein.

         14. Paragraph Titles. The paragraph titles used in this Agreement are
for convenience of reference only and will not be considered in the
interpretation or construction of any of the provisions thereof.

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         IN WITNESS WHEREOF, the parties have caused this Agreement to be
executed as a sealed instrument by their duly authorized officers as of the date
first above written.

                                   PREMIER RESEARCH WORLDWIDE, LTD.

                                   By:/s/ Joel Morganroth
                                      ------------------------------------------
                                          Joel Morganroth, M.D.
                                          Chairman and Chief Executive Officer

                                   eRESEARCH TECHNOLOGY, INC.

                                   By: /s/ Joseph A. Esposito
                                      ------------------------------------------
                                           Joseph A. Esposito
                                           President and Chief Executive Officer

                                      - 6 -

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                                    EXHIBIT I
                     FINANCIAL SERVICES PROVIDED TO PREMIER

Banking Services Administration
         Select banks and establish accounts
         Administer cash balances
         Administer outstanding indebtedness
         Administer any debt covenant compliance issues
         Maintain a cash collections and disbursement system
         Arrange letters of credit and cash transfers
         Manage any foreign currency exchange needs

Financial Management and Information
         Cash management
         Pension fund management
         Leasing management services
         Customer financing
         Information on financial markets and products
         Information on foreign currency, risk assessment and hedge strategies

Arrange Credit Support
         Insurance performance and bid bonds
         Letters of credit
         Corporate guarantees

Investment Banking Services
         Advice and support for equity and debt financing
         Manage relationships with debt rating agencies
         Analysis, negotiations, advice and support for mergers and acquisitions

<PAGE>

                  Supplement to Services and Support Agreement

         This Supplement to Services and Support Agreement (the "Supplement")
dated April 17, 2000 is made by and between PRWW, Ltd., a Delaware corporation
("PRWW") and eResearchTechnology, Inc., a Delaware corporation ("eRT").

                                   Background

         PRWW and eRT are parties to a Services and Support Agreement dated as
of January 1, 2000 (the "Agreement") under which each party has agreed to
provide certain services and supports to the other for certain specified
consideration. The parties desire to supplement the Agreement effective as of
January 1, 2000 to reflect that PRWW has also provided to eRT, and will continue
to provide to eRT, certain strategic planning and direction through the services
of Joel Morganroth, M.D., PRWW's Chairman and Chief Executive Officer, for which
eRT is willing to compensate PRWW.

         NOW, THEREFORE, in consideration of the premises and the mutual
covenants contained herein, and intending to be legally bound hereby, the
parties agree as follows:

         1. Effective Date. This Supplement shall be effective as of January 1,
2000.

         2. Additional Services to be Provided by PRWW. In addition to the
services specified in the Agreement, PRWW agrees to make its Chairman and Chief
Executive Officer, Joel Morganroth, M.D. available to provide management
support, consultation and advice to eRT regarding strategic business planning,
corporate development, acquisitions, technology and securities law compliance
matters.

         3. Consideration. The parties acknowledge that the services provided
pursuant to Section 2 of this Supplement are anticipated to require
approximately 50% of Dr. Morganroth's business time excluding the time he
performs services for eRT pursuant to the terms of the Management Consulting
Agreement dated as of January 1, 2000 between eRT and Joel Morganroth, M.D.,
P.C. Accordingly, in consideration for the services specified in Section 2
hereof, eRT shall pay to PRWW an amount equal to 50% of the salary paid by PRWW
to Dr. Morganroth during the term of the Agreement.

<PAGE>

         4. Survival of Agreement. As supplemented hereby, the terms and
provisions of the Agreement shall remain in full force and effect.

         IN WITNESS WHEREOF, the undersigned have executed this Supplement as of
the day and year first above written.

                                     PRWW, Ltd.

                                     By: /s/ Joel Morganroth
                                         --------------------------------------
                                         Joel Morganroth, M.D.
                                         Chairman and Chief Executive Officer

                                     eResearchTechnology, Inc.

                                     By: /s/Joseph A. Esposito
                                         --------------------------------------
                                         Joseph A. Esposito,
                                         President and Chief Executive Officer

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