Document:

ex4-12

 

AMENDMENT NO. 1 TO THE AGENCY AGREEMENT

     AMENDMENT NO. 1, dated as of April 10, 2001, to the Agency Agreement,
dated as of July 17, 1997 (the “Agency Agreement”), among MBNA America Bank,
National Association (the “Bank”), Bank One Trust Company, N.A.
(successor-in-interest to The First Chicago National Bank of Chicago) (“Bank
One”) as global agent (the “Global Agent”), Bank One, NA, London Branch (“Bank
One London”) acting through its specified office in London as paying agent
(“London Paying Agent”) and as issuing agent (the “London Issuing Agent”), Bank
One acting through its specified office in New York as registrar (the
“Registrar”) and paying agent (the “New York Paying Agent”) and Crédit Agricole
Indosuez (“Crédit Agricole”) in its capacity as transfer agent (the “Transfer
Agent”) and as paying agent (the “Luxembourg Paying Agent”; and together with
the London Paying Agent and the New York Paying Agent, the “Paying Agents”;
individually, a “Paying Agent”).

W I T N E S S E T H

     WHEREAS, the Bank has agreed to issue and sell its Bank Notes (the
“Notes”) subject to, and with the benefit of, the Agency Agreement; and

     WHEREAS, the Bank, the Global Agent, the Paying Agents, the Transfer
Agent, the London Issuing Agent and the Registrar wish to amend the Agency
Agreement in the manner set forth herein;

     NOW THEREFORE, the parties hereto hereby agree as follows:

     1.     Defined Terms. Capitalized terms not otherwise defined herein shall
have the meanings ascribed to them in the Agency Agreement.

     2.     Amendments to the Agency Agreement.

     (a)  The Agency Agreement is hereby amended by replacing all references to
The First National Bank of Chicago (“First Chicago”) with Bank One Trust
Company, N.A. (“Bank One”).

     (b)  The Agency Agreement is hereby amended by replacing all references to
“First Chicago London” with “Bank One London”.

     (c)  The Agency Agreement is hereby amended by replacing all references to
“First Chicago New York” with “Bank One New York”.

     (d)  The Agency Agreement is hereby amended by replacing all references to
Banque Indosuez Luxembourg (“Banque Indosuez”) with Crédit Agricole Indosuez
(“Crédit Agricole”).

     (e)  The Agency Agreement is hereby amended by deleting the WHEREAS Clause
(A) in its entirety and substituting in lieu thereof the following:

			
	“(A)		The Bank has entered into an
Amended and Restated Dealer Agreement dated as of April
10, 2001 with certain Dealers named therein pursuant to
which the Bank may from time to

 

 

		
	 	time issue up to US$10,000,000,000 aggregate principal
amount (or the equivalent thereof in other currencies)
of its Bank Notes (the “Notes”). The Bank may at any
time increase the maximum aggregate principal amount
of the Notes that may be issued or outstanding at any
one time pursuant to the Program (as defined herein);
provided, that the Bank shall promptly notify the
Agents of any such increase.”

     (f)  The Agency Agreement is hereby amended by deleting Section (b) of the
definition of “Business Day” contained in Section 1 of the Agency Agreement in
its entirety and substituting in lieu thereof the following:

			
	“(b)		either (i) in relation to a payment to be made in a
Specified Currency other than the Euro, a day on which
commercial banks and foreign exchange markets settle
payments in the principal financial center of the country of
the relevant Specified Currency (if other than The City of
New York) or (ii) in relation to Notes denominated in Euro,
a day (other than a Saturday or Sunday) on which the
Trans-European Automated Real-Time Gross Settlement Express
Transfer (TARGET) System (“Target”) or any successor thereto
is open ( a “Target Settlement Day”).”

     (g)  The Agency Agreement is hereby amended by deleting the defined term
“Cedel” throughout the Agency Agreement and substituting in lieu thereof the
words “Clearstream, Luxembourg”. The following definition of “Clearstream,
Luxembourg” shall be added to the definitions contained in Section 1 of the
Agency Agreement:

		
	 	     “Clearstream, Luxembourg” means Clearstream Banking, société
anonyme or any successor thereto.

     (h)  The Agency Agreement is hereby amended by adding Banc of America
Securities LLC, Banc of America Securities Limited, Chase Securities Inc.,
Deutsche Banc Alex. Brown Inc., Deutsche Bank AG London, Salomon Smith Barney
Inc. and Salomon Brothers International Limited to the definition of “Dealer”
and by deleting Banque Lehman Brothers from the definition of “Dealer”.

     (i)  The Agency Agreement is hereby amended by deleting the definition for
“Euroclear” contained in Section 1 of the Agency Agreement in its entirety and
substituting in lieu thereof the following:

		
	 	     “means Euroclear Bank S.A./N.V., as operator of the Euroclear
System or any successor thereto.”

     (j)  The Agency Agreement is hereby amended by deleting the defined term
“Euroclear/Cedel Global Note” throughout the Agency Agreement and substituting
in lieu thereof “Euroclear/Clearstream, Luxembourg Global Note”. The following
definition of “Euroclear/Clearstream, Luxembourg Global Note”) shall be added
to the definitions contained in Section 1 of the Agency Agreement:

 

 

		
	 	     “Euroclear/Clearstream, Luxembourg Global Note” means a
Registered Global Note deposited with a common depositary for, and
registered in the name of a nominee of, Euroclear and/or
Clearstream, Luxembourg.

     (k)  The Agency Agreement is hereby amended by adding the following clause
(iv) to Section 27(a) of the Agency Agreement:

			
	“(iv)		The Bank undertakes that, if the
conclusions of the ECOFIN Council meeting of November
26-27, 2000 are implemented, it will ensure that it
maintains a paying agent in a member state of the
European Union that will not be obliged to withhold or
deduct tax pursuant to the European Union Savings Tax
Directive.”

     3.     Continuing Effect of the Agency Agreement. Except as expressly amended
hereby, the provisions of the Agency Agreement are and shall remain in full
force and effect.

     4.     Counterparts. This Amendment No. 1 to the Agency Agreement may be
executed by the parties hereto in any number of separate counterparts, each of
which shall be deemed to be an original, and all of which taken together shall
be deemed to constitute one and the same instrument.

     5.     GOVERNING LAW. THIS AMENDMENT NO. 1 TO THE AGENCY AGREEMENT SHALL BE
GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF NEW
YORK.

 

 

     IN WITNESS WHEREOF, the parties hereto have executed this Amendment No. 1
to the Agency Agreement as of the date first written above.

	 	 
		THE BANK
	 
		MBNA AMERICA BANK, NATIONAL ASSOCIATION
	 
		By:                                             

      Name:

      Title:
	 
		
	 
		THE GLOBAL AGENT
	 
		BANK ONE TRUST COMPANY, N.A
	 
		By:                                              

      Name:

      Title:
	 
		
	 
		THE REGISTRAR AND NEW YORK PAYING AGENT
	 
		BANK ONE TRUST COMPANY, N.A
	 
		By:                                               

     Name:

     Title:
	 
		
	 
		THE LONDON PAYING AGENT AND
  LONDON
ISSUING AGENT
	 
		BANK ONE, NA, LONDON BRANCH
	 
		By:                                              

     Name: 

     Title:
	 
		
	 
		THE LUXEMBOURG PAYING AGENT AND TRANSFER
AGENT
	 
		CRÉDIT AGRICOLE INDOSUEZ
	 
		By:                                                 

      Name:

      Title:<PAGE>
                                                                     EXHIBIT 4.4

       ------------------------------------------------------------------

                                 INFORMAX, INC.

                         2001 EMPLOYEE STOCK OPTION PLAN

       ------------------------------------------------------------------

<PAGE>

                                TABLE OF CONTENTS

<TABLE>
<CAPTION>
                                                                                                   PAGE
                                                                                                   ----

<S>                                                                                               <C>
1.    PURPOSE........................................................................................1
2.    DEFINITIONS....................................................................................1
3.    ADMINISTRATION OF THE PLAN.....................................................................4
      3.1.     Board.................................................................................4
      3.2.     Committee.............................................................................4
      3.3.     Terms of Awards.......................................................................5
      3.4.     No Liability..........................................................................5
4.    STOCK SUBJECT TO THE PLAN......................................................................6
5.    EFFECTIVE DATE, DURATION AND AMENDMENTS........................................................6
      5.1.     Effective Date........................................................................6
      5.2.     Term..................................................................................6
      5.3.     Amendment and Termination of the Plan.................................................6
6.    AWARD ELIGIBILITY AND LIMITATIONS..............................................................6
      6.1.     Company or Subsidiary Employees; Service Providers....................................6
      6.2.     Successive Awards.....................................................................7
      6.3.     Stand-Alone, Additional, Tandem, and Substitute Awards................................7
7.    AWARD AGREEMENT................................................................................7
8.    TERMS AND CONDITIONS OF OPTIONS................................................................7
      8.1.     Option Price..........................................................................7
      8.2.     Vesting...............................................................................7
      8.3.     Term..................................................................................8
      8.4.     Termination of Service................................................................8
      8.5.     Limitations on Exercise of Option.....................................................8
      8.6.     Method of Exercise....................................................................8
      8.7.     Rights of Holders of Options..........................................................8
      8.8.     Delivery of Stock Certificates........................................................8
      8.9.     Reload Options........................................................................9
9.    TRANSFERABILITY OF OPTIONS.....................................................................9
      9.1.     Transferability of Options............................................................9
      9.2.     Family Transfers......................................................................9
10.   FORM OF PAYMENT FOR OPTIONS....................................................................9
      10.1.    General Rule..........................................................................9
      10.2.    Surrender of Stock....................................................................10
      10.3.    Cashless Exercise.....................................................................10
      10.4.    Promissory Note.......................................................................10
      10.5.    Other Forms of Payment................................................................10
11.   PARACHUTE LIMITATIONS..........................................................................10
12.   REQUIREMENTS OF LAW............................................................................11
      12.1.    General...............................................................................11
      12.2.    Rule 16b-3............................................................................12
13.   EFFECT OF CHANGES IN CAPITALIZATION............................................................12
      13.1.    Changes in Stock......................................................................12
</TABLE>

                                      -i-

<PAGE>

<TABLE>
<S>                                                                                               <C>
      13.2.    Reorganization in Which the Company Is the Surviving Entity Which does
               not Constitute a Corporate Transaction................................................13
      13.3.    Corporate Transaction.................................................................13
      13.4.    Adjustments...........................................................................14
      13.5.    No Limitations on Company.............................................................14
14.   GENERAL PROVISIONS.............................................................................14
      14.1.    Disclaimer of Rights..................................................................14
      14.2.    Nonexclusivity of the Plan............................................................14
      14.3.    Withholding Taxes.....................................................................15
      14.4.    Captions..............................................................................15
      14.5.    Other Provisions......................................................................15
      14.6.    Number And Gender.....................................................................15
      14.7.    Severability..........................................................................15
      14.8.    Governing Law.........................................................................15
</TABLE>

                                      -ii-
<PAGE>

                                 INFORMAX, INC.

                         2001 EMPLOYEE STOCK OPTION PLAN

        Informax, Inc., a Delaware corporation (the "Company"), sets forth
herein the terms of its 2001 Employee Stock Option Plan (the "Plan"), as
follows:

1.      PURPOSE

        The Plan is intended to enhance the Company's and its Affiliates' (as
defined herein) ability to attract and retain highly qualified officers,
directors, and key employees, and to motivate such persons to serve the Company
and its Affiliates and to expend maximum effort to improve the business results
and earnings of the Company, by providing to such persons an opportunity to
acquire or increase a direct proprietary interest in the operations and future
success of the Company. To this end, the Plan provides for the grant of stock
options. Stock options granted under the Plan shall be non-qualified stock
options. This Plan is intended to be a broadly-based plan within the meaning of
the Nasdaq Marketplace rules. Accordingly, it is expected that a majority of the
participants in the Plan will be persons who are not officers or directors, and
that officers and directors will not receive a majority of the grants under the
Plan.

2.      DEFINITIONS

        For purposes of interpreting the Plan and related documents (including
Award Agreements), the following definitions shall apply:

        2.1     "AFFILIATE" means, with respect to the Company, any company or
other trade or business that controls, is controlled by or is under common
control with the Company within the meaning of Rule 405 of Regulation C under
the Securities Act, including, without limitation, any Subsidiary.

        2.2     "AWARD" means a grant of an Option.

        2.3     "AWARD AGREEMENT" means the written agreement between the
Company and a Grantee that evidences and sets out the terms and conditions of an
Award.

        2.4     "BENEFIT ARRANGEMENT" shall have the meaning set forth in
SECTION 11 hereof.

        2.5     "BOARD" means the Board of Directors of the Company.

        2.6     "CAUSE" means, as determined by the Board and unless otherwise
provided in an applicable agreement with the Company or an Affiliate, (i) gross
negligence or willful misconduct in connection with the performance of duties;
(ii) conviction of a criminal offense (other than minor traffic offenses); or
(iii) material breach of any term of any employment, consulting or other
services, confidentiality, intellectual property or non- competition agreements,
if any, between the Service Provider and the Company or an Affiliate.

<PAGE>

        2.7     "CODE" means the Internal Revenue Code of 1986, as now in effect
or as hereafter amended.

        2.8     "COMMITTEE" means a committee of, and designated from time to
time by resolution of, the Board, which shall be constituted as provided in
SECTION 3.2.

        2.9     "COMPANY" means Informax, Inc.

        2.10    "CORPORATE TRANSACTION" means (i) the dissolution or liquidation
of the Company or a merger, consolidation, or reorganization of the Company with
one or more other entities in which the Company is not the surviving entity,
(ii) a sale of substantially all of the assets of the Company to another person
or entity, or (iii) any transaction (including without limitation a merger or
reorganization in which the Company is the surviving entity) which results in
any person or entity (other than persons who are stockholders or Affiliates
immediately prior to the transaction) owning 80% or more of the combined voting
power of all classes of stock of the Company.

        2.11    "DISABILITY" means the Grantee is unable to perform each of the
essential duties of such Grantee's position by reason of a medically
determinable physical or mental impairment which is potentially permanent in
character or which can be expected to last for a continuous period of not less
than 12 months.

        2.12    "EFFECTIVE DATE" means December 20, 2001, the date the Plan is
approved by the Board.

        2.13    "EXCHANGE ACT" means the Securities Exchange Act of 1934, as now
in effect or as hereafter amended.

        2.14    "FAIR MARKET VALUE" means the value of a share of Stock,
determined as follows: if on the Grant Date or other determination date the
Stock is listed on an established national or regional stock exchange, is
admitted to quotation on The Nasdaq Stock Market, Inc. or is publicly traded on
an established securities market, the Fair Market Value of a share of Stock
shall be the closing price of the Stock on such exchange or in such market (if
there is more than one such exchange or market the Board shall determine the
appropriate exchange or market) on the date preceding the Grant Date or such
other determination date (or if there is no such reported closing price, the
Fair Market Value shall be the mean between the highest bid and lowest asked
prices or between the high and low sale prices on such trading day) or, if no
sale of Stock is reported for such trading day, on the next preceding day on
which any sale shall have been reported. If the Stock is not listed on such an
exchange, quoted on such system or traded on such a market, Fair Market Value
shall be the value of the Stock as determined by the Board in good faith.

        2.15    "FAMILY MEMBER" means a person who is a spouse, former spouse,
child, stepchild, grandchild, parent, stepparent, grandparent, niece, nephew,
mother-in-law, father-in-law, son-in-law, daughter-in-law, brother, sister,
brother-in-law, or sister-in-law, including adoptive relationships, of the
Grantee, any person sharing the Grantee's household (other than a tenant or
employee), a trust in which any one or more of these persons have more than
fifty percent of the beneficial interest, a foundation in which any one or more
of these persons (or the Grantee) control the management of assets, and any
other entity in which one or more of these persons (or the Grantee) own more
than fifty percent of the voting interests.

                                     - 2 -
<PAGE>

        2.16    "GRANT DATE" means, as determined by the Board or authorized
Committee, the latest to occur of (i) the date as of which the Board approves an
Award, (ii) the date on which the recipient of an Award first becomes eligible
to receive an Award under SECTION 6 hereof, or (iii) such other date as may be
specified by the Board.

        2.17    "GRANTEE" means a person who receives or holds an Award under
the Plan.

        2.18    "INCENTIVE STOCK OPTION" means an "incentive stock option"
within the meaning of Section 422 of the Code, or the corresponding provision of
any subsequently enacted tax statute, as amended from time to time.

        2.19    "NON-QUALIFIED STOCK OPTION" means an Option that is not an
Incentive Stock Option.

        2.20    "OPTION" means an option to purchase one or more shares of Stock
pursuant to the Plan.

        2.21    "OPTION PRICE" means the purchase price for each share of Stock
subject to an Option.

        2.22    "OTHER AGREEMENT" shall have the meaning set forth in SECTION 11
hereof.

        2.23    "OUTSIDE DIRECTOR" means a member of the Board who is not an
officer or employee of the Company.

        2.24    "PLAN" means this Informax, Inc. 2001 Employee Stock Option
Plan.

        2.25    "REPORTING PERSON" means a person who is required to file
reports under Section 16(a) of the Exchange Act.

        2.26    "SECURITIES ACT" means the Securities Act of 1933, as now in
effect or as hereafter amended.

        2.27    "SERVICE" means service as an employee, officer, director or
other Service Provider of the Company or an Affiliate. Unless otherwise stated
in the applicable Award Agreement, a Grantee's change in position or duties
shall not result in interrupted or terminated Service, so long as such Grantee
continues to be an employee, officer, director or other Service Provider of the
Company or an Affiliate. Subject to the preceding sentence, whether a
termination of Service shall have occurred for purposes of the Plan shall be
determined by the Board, which determination shall be final, binding and
conclusive.

                                     - 3 -
<PAGE>

        2.28    "SERVICE PROVIDER" means an employee, officer or director of the
Company or an Affiliate, or a consultant or adviser currently providing services
to the Company or an Affiliate.

        2.29    "STOCK" means the common stock, par value $.001 per share, of
the Company.

        2.30    "SUBSIDIARY" means any "subsidiary corporation" of the Company
within the meaning of Section 424(f) of the Code.

        2.31    "TERMINATION DATE" means the date upon which an Option shall
terminate or expire, as set forth in SECTION 8.3 hereof.

3.      ADMINISTRATION OF THE PLAN

        3.1.    BOARD

        The Board shall have such powers and authorities related to the
administration of the Plan as are consistent with the Company's certificate of
incorporation and by-laws and applicable law. The Board shall have full power
and authority to take all actions and to make all determinations required or
provided for under the Plan, any Award or any Award Agreement, and shall have
full power and authority to take all such other actions and make all such other
determinations not inconsistent with the specific terms and provisions of the
Plan that the Board deems to be necessary or appropriate to the administration
of the Plan, any Award or any Award Agreement. All such actions and
determinations shall be by the affirmative vote of a majority of the members of
the Board present at a meeting or by unanimous consent of the Board executed in
writing in accordance with the Company's certificate of incorporation and
by-laws and applicable law. The interpretation and construction by the Board of
any provision of the Plan, any Award or any Award Agreement shall be final and
conclusive.

        3.2.    COMMITTEE.

        The Board may appoint a committee (the "Committee") of the Board,
composed of one or more directors of the Company who need not be Outside
Directors, to grant Awards under the Plan to employees or other Service
Providers. The Board from time to time may delegate to the Committee such powers
and authorities related to the administration and implementation of the Plan, as
set forth in SECTION 3.1 above and other applicable provisions, as the Board
shall determine, consistent with the certificate of incorporation and by-laws of
the Company and applicable law. In the event that the Plan, any Award or any
Award Agreement entered into hereunder provides for any action to be taken by or
determination to be made by the Board, such action may be taken or such
determination may be made by the Committee if the power and authority to do so
has been delegated to the Committee by the Board as provided for in this
Section. Unless otherwise expressly determined by the Board, any such action or
determination by the Committee shall be final, binding and conclusive. To the
extent permitted by law, the Board or the Committee may delegate its authority
under the Plan to grant Options to an officer of the Company.

                                     - 4 -
<PAGE>

        3.3.    TERMS OF AWARDS.

        Subject to the other terms and conditions of the Plan, the Board shall
have full and final authority to:

        (i)     designate Grantees,

        (ii)    determine the type or types of Awards to be made to a Grantee,

        (iii)   determine the number of shares of Stock to be subject to an
Award,

        (iv)    establish the terms and conditions of each Award (including, but
not limited to, the exercise price of any Option and the nature and duration of
any restriction or condition (or provision for lapse thereof) relating to the
vesting, exercise, transfer, or forfeiture of an Award or the shares of Stock
subject thereto),

        (v)     prescribe the form of each Award Agreement evidencing an Award,
and

        (vi)    amend, modify, or supplement the terms of any outstanding Award.
Such authority specifically includes the authority, in order to effectuate the
purposes of the Plan but without amending the Plan, to modify Awards to eligible
individuals who are foreign nationals or are individuals who are employed
outside the United States to recognize differences in local law, tax policy, or
custom.

        As a condition to any subsequent Award, the Board shall have the right,
at its discretion, to require Grantees to return to the Company Awards
previously made under the Plan. Subject to the terms and conditions of the Plan,
any such new Award shall be upon such terms and conditions as are specified by
the Board at the time the new Award is made. The Board shall have the right, in
its discretion, to make Awards in substitution or exchange for any other award
under another plan of the Company, any Affiliate, or any business entity to be
acquired by the Company or an Affiliate. The Company may retain the right in an
Award Agreement to cause a forfeiture of the gain realized by a Grantee on
account of actions taken by the Grantee in violation or breach of or in conflict
with any non-competition agreement, any agreement prohibiting solicitation of
employees or clients of the Company or any Affiliate thereof or any
confidentiality obligation with respect to the Company or any Affiliate thereof
or otherwise in competition with the Company or any Affiliate thereof, to the
extent specified in such Award Agreement applicable to the Grantee. Furthermore,
the Company may annul an Award if the Grantee is an employee of the Company or
an Affiliate thereof and is terminated for Cause as defined in the applicable
Award Agreement or the Plan, as applicable. The grant of any Award shall be
contingent upon the Grantee executing the appropriate Award Agreement.

        3.4.    NO LIABILITY.

        No member of the Board or of the Committee shall be liable for any
action or determination made in good faith with respect to the Plan or any Award
or Award Agreement.

                                     - 5 -
<PAGE>

4.      STOCK SUBJECT TO THE PLAN

        Subject to adjustment as provided in SECTION 13 hereof, the number of
shares of Stock available for issuance under the Plan shall be one million five
hundred thousand (1,500,000). Stock issued or to be issued under the Plan shall
be authorized but unissued shares; or, to the extent permitted by applicable
law, issued shares that have been reacquired by the Company or treasury shares.
If any shares covered by an Award are not purchased or are forfeited, or if an
Award otherwise terminates without delivery of any Stock subject thereto, then
the number of shares of Stock counted against the aggregate number of shares
available under the Plan with respect to such Award shall, to the extent of any
such forfeiture or termination, again be available for making Awards under the
Plan. If the Option Price of any Option granted under the Plan, or if pursuant
to SECTION 14.3 the withholding obligation of any Grantee with respect to an
Option, is satisfied by tendering shares of Stock to the Company (by either
actual delivery or by attestation) or by withholding shares of Stock, only the
number of shares of Stock issued net of the shares of Stock tendered or withheld
shall be deemed delivered for purposes of determining the maximum number of
shares of Stock available for delivery under the Plan.

5.      EFFECTIVE DATE, DURATION AND AMENDMENTS

        5.1.    EFFECTIVE DATE.

        The Plan shall be effective as of the Effective Date.

        5.2.    TERM.

        The Plan shall terminate automatically ten (10) years after its adoption
by the Board and may be terminated on any earlier date as provided in SECTION
5.3.

        5.3.    AMENDMENT AND TERMINATION OF THE PLAN

        The Board may, at any time and from time to time, amend, suspend, or
terminate the Plan as to any shares of Stock as to which Awards have not been
made. An amendment shall be contingent on approval of the Company's stockholders
to the extent stated by the Board or required by applicable law. No Awards shall
be made after termination of the Plan. No amendment, suspension, or termination
of the Plan shall, without the consent of the Grantee, impair rights or
obligations under any Award theretofore awarded under the Plan.

6.      AWARD ELIGIBILITY AND LIMITATIONS

        6.1.    COMPANY OR SUBSIDIARY EMPLOYEES; SERVICE PROVIDERS

        Awards may be made under the Plan to any employee of, or other Service
Provider to, the Company or of any Affiliate, including any such employee or
other Service Provider who is an officer or director of the Company, or of any
Affiliate, as the Board shall determine and designate from time to time.

                                     - 6 -
<PAGE>

        6.2.    SUCCESSIVE AWARDS.

        An eligible person may receive more than one Award, subject to such
restrictions as are provided herein.

        6.3.    STAND-ALONE, ADDITIONAL, TANDEM, AND SUBSTITUTE AWARDS

        Awards granted under the Plan may, in the discretion of the Board, be
granted either alone or in addition to, in tandem with, or in substitution or
exchange for, any other Award or any award granted under another plan of the
Company, any Affiliate, or any business entity to be acquired by the Company or
an Affiliate, or any other right of a Grantee to receive payment from the
Company or any Affiliate. Such additional, tandem, and substitute or exchange
Awards may be granted at any time. If an Award is granted in substitution or
exchange for another Award, the Board shall require the surrender of such other
Award in consideration for the grant of the new Award.

7.      AWARD AGREEMENT

        Each Award granted pursuant to the Plan shall be evidenced by an Award
Agreement, in such form or forms as the Board shall from time to time determine.
Award Agreements granted from time to time or at the same time need not contain
similar provisions but shall be consistent with the terms of the Plan. Each
Award Agreement evidencing an Award of Options shall specify that such Options
are intended to be Non-qualified Stock Options.

8.      TERMS AND CONDITIONS OF OPTIONS

        8.1.    OPTION PRICE

        The Option Price of each Option shall be fixed by the Board and stated
in the Award Agreement evidencing such Option. In no case shall the Option Price
of any Option be less than the par value of a share of Stock.

        8.2.    VESTING.

        Subject to SECTIONS 8.3 AND 13.3 hereof, each Option granted under the
Plan shall become exercisable at such times and under such conditions as shall
be determined by the Board and stated in the Award Agreement. For purposes of
this SECTION 8.2, fractional numbers of shares of Stock subject to an Option
shall be rounded down to the next nearest whole number. The Board may provide,
for example, in the Award Agreement for (i) accelerated exercisability of the
Option in the event the Grantee's Service terminates on account of death,
Disability or another event, (ii) expiration of the Option prior to its term in
the event of the termination of the Grantee's Service, (iii) immediate
forfeiture of the Option in the event the Grantee's Service is terminated for
Cause or (iv) unvested Options to be exercised subject to the Company's right of
repurchase with respect to unvested shares of Stock.

                                     - 7 -
<PAGE>

        8.3.    TERM.

        Each Option granted under the Plan shall terminate, and all rights to
purchase shares of Stock thereunder shall cease, upon the expiration of ten
years from the date such Option is granted, or under such circumstances and on
such date prior thereto as is set forth in the Plan or as may be fixed by the
Board and stated in the Award Agreement relating to such Option (the
"Termination Date").

        8.4.    TERMINATION OF SERVICE.

        Each Award Agreement shall set forth the extent to which the Grantee
shall have the right to exercise the Option following termination of the
Grantee's Service. Such provisions shall be determined in the sole discretion of
the Board, need not be uniform among all Options issued pursuant to the Plan,
and may reflect distinctions based on the reasons for termination of Service.

        8.5.    LIMITATIONS ON EXERCISE OF OPTION.

        Notwithstanding any other provision of the Plan, in no event may any
Option be exercised, in whole or in part, after ten years following the Grant
Date or after the occurrence of an event referred to in SECTION 13 hereof which
results in termination of the Option.

        8.6.    METHOD OF EXERCISE.

        An Option that is exercisable may be exercised by the Grantee's delivery
to the Company of written notice of exercise on any business day, at the
Company's principal office, on the form specified by the Company. Such notice
shall specify the number of shares of Stock with respect to which the Option is
being exercised and shall be accompanied by payment in full of the Option Price
of the shares for which the Option is being exercised. The minimum number of
shares of Stock with respect to which an Option may be exercised, in whole or in
part, at any time shall be the lesser of (i) 100 shares or such lesser number
set forth in the applicable Award Agreement and (ii) the maximum number of
shares available for purchase under the Option at the time of exercise.

        8.7.    RIGHTS OF HOLDERS OF OPTIONS

        Unless otherwise stated in the applicable Award Agreement, an individual
holding or exercising an Option shall have none of the rights of a stockholder
(for example, the right to receive cash or dividend payments or distributions
attributable to the subject shares of Stock or to direct the voting of the
subject shares of Stock ) until the shares of Stock covered thereby are fully
paid and issued to him. Except as provided in SECTION 13 hereof, no adjustment
shall be made for dividends, distributions or other rights for which the record
date is prior to the date of such issuance.

        8.8.    DELIVERY OF STOCK CERTIFICATES.

        Promptly after the exercise of an Option by a Grantee and the payment in
full of the Option Price, such Grantee shall be entitled to the issuance of a
stock certificate or certificates evidencing his or her ownership of the shares
of Stock subject to the Option.

                                     - 8 -
<PAGE>

        8.9.    RELOAD OPTIONS.

        At the discretion of the Board and subject to such restrictions, terms
and conditions as the Board may establish, Options granted under the Plan may
include a "reload" feature pursuant to which a Grantee exercising an Option by
the delivery of a number of shares of Stock in accordance with SECTION 8.6
hereof would automatically be granted an additional Option (with an Option Price
equal to the Fair Market Value of the Stock on the date the additional Option is
granted and with such other terms as the Board may provide) to purchase that
number of shares of Stock equal to the number delivered to exercise the original
Option with an Option term equal to the remainder of the original Option term
unless the Board otherwise determines in the Option Award Agreement for the
original grant.

9.      TRANSFERABILITY OF OPTIONS

        9.1.    TRANSFERABILITY OF OPTIONS

        Except as provided in SECTION 9.2, during the lifetime of a Grantee,
only the Grantee (or, in the event of legal incapacity or incompetency, the
Grantee's guardian or legal representative) may exercise an Option. Except as
provided in SECTION 9.2, no Option shall be assignable or transferable by the
Grantee to whom it is granted, other than by will or the laws of descent and
distribution.

        9.2.    FAMILY TRANSFERS.

        If authorized in the applicable Award Agreement, a Grantee may transfer,
not for value, all or part of an Option to any Family Member. For the purpose of
this SECTION 9.2, a "not for value" transfer is a transfer which is (i) a gift,
(ii) a transfer under a domestic relations order in settlement of marital
property rights; or (iii) a transfer to an entity in which more than fifty
percent of the voting interests are owned by Family Members (or the Grantee) in
exchange for an interest in that entity. Following a transfer under this SECTION
9.2, any such Option shall continue to be subject to the same terms and
conditions as were applicable immediately prior to transfer. Subsequent
transfers of transferred Options are prohibited except to Family Members of the
original Grantee in accordance with this SECTION 9.2 or by will or the laws of
descent and distribution. The events of termination of Service of SECTION 8.4
hereof shall continue to be applied with respect to the original Grantee,
following which the Option shall be exercisable by the transferee only to the
extent, and for the periods specified, in SECTION 8.4.

10.     FORM OF PAYMENT FOR OPTIONS

        10.1.   GENERAL RULE.

        Payment of the Option Price for the shares purchased pursuant to the
exercise of an Option shall be made in cash or in cash equivalents acceptable to
the Company.

                                     - 9 -
<PAGE>

        10.2.   SURRENDER OF STOCK.

        To the extent the Award Agreement so provides, payment of the Option
Price for shares purchased pursuant to the exercise of an Option may be made all
or in part through the tender to the Company of shares of Stock, which shares,
if acquired from the Company, shall have been held for at least six months at
the time of tender and which shall be valued, for purposes of determining the
extent to which the Option Price has been paid thereby, at their Fair Market
Value on the date of exercise.

        10.3.   CASHLESS EXERCISE.

        To the extent the Award Agreement so provides, payment of the Option
Price for shares purchased pursuant to the exercise of an Option may be made all
or in part by delivery (on a form acceptable to the Board) of an irrevocable
direction to a licensed securities broker acceptable to the Company to sell
shares of Stock and to deliver all or part of the sales proceeds to the Company
in payment of the Option Price and any withholding taxes described in SECTION
14.3.

        10.4.   PROMISSORY NOTE.

        To the extent the Award Agreement so provides, payment of the Option
Price for shares purchased pursuant to the exercise of an Option may be made all
or in part with a full recourse promissory note executed by the Grantee. The
interest rate and other terms and conditions of such note shall be determined by
the Board. The Board may require that the Grantee pledge the Stock subject to
the Award for the purpose of securing payment of the note. Unless the Board
determines otherwise, the stock certificate(s) representing the Stock shall not
be released to the Grantee until such note is paid in full.

        10.5.   OTHER FORMS OF PAYMENT.

        To the extent the Award Agreement so provides, payment of the Option
Price for shares purchased pursuant to exercise of an Option may be made in any
other form that is consistent with applicable laws, regulations and rules.

11.     PARACHUTE LIMITATIONS

        Notwithstanding any other provision of this Plan or of any other
agreement, contract, or understanding heretofore or hereafter entered into by a
Grantee with the Company or any Affiliate, except an agreement, contract, or
understanding hereafter entered into that expressly modifies or excludes
application of this paragraph (an "Other Agreement"), and notwithstanding any
formal or informal plan or other arrangement for the direct or indirect
provision of compensation to the Grantee (including groups or classes of
Grantees or beneficiaries of which the Grantee is a member), whether or not such
compensation is deferred, is in cash, or is in the form of a benefit to or for
the Grantee (a "Benefit Arrangement"), if the Grantee is a "disqualified
individual," as defined in Section 280G(c) of the Code, any Option held by that
Grantee and any right to receive any payment or other benefit under this Plan
shall not become exercisable or vested (i) to the extent that such right to
exercise, vesting, payment, or benefit, taking into account all other rights,
payments, or benefits to or for the Grantee under this Plan, all Other
Agreements, and all Benefit Arrangements, would cause any payment or benefit to
the Grantee under this Plan to be considered a "parachute payment" within the
meaning of Section 280G(b)(2) of the Code as then in effect (a "Parachute
Payment") and (ii) if, as a result of receiving a Parachute Payment, the
aggregate after-tax amounts received by the Grantee from the Company under this
Plan, all Other Agreements, and all Benefit Arrangements would be less than the
maximum after-tax amount that could be received by the Grantee without causing
any such payment or benefit to be considered a Parachute Payment. In the event
that the receipt of any such right to exercise, vesting, payment, or benefit
under this Plan, in conjunction with all other rights, payments, or benefits to
or for the Grantee under any Other Agreement or any Benefit Arrangement would
cause the Grantee to be considered to have received a Parachute Payment under
this Plan that would have the effect of decreasing the after-tax amount received
by the Grantee as described in clause (ii) of the preceding sentence, then the
Grantee shall have the right, in the Grantee's sole discretion, to designate
those rights, payments, or benefits under this Plan, any Other Agreements, and
any Benefit Arrangements that should be reduced or eliminated so as to avoid
having the payment or benefit to the Grantee under this Plan be deemed to be a
Parachute Payment.

                                     - 10 -
<PAGE>

12.     REQUIREMENTS OF LAW

        12.1.   GENERAL.

        The Company shall not be required to sell or issue any shares of Stock
under any Award if the sale or issuance of such shares would constitute a
violation by the Grantee, any other individual exercising an Option, or the
Company of any provision of any law or regulation of any governmental authority,
including without limitation any federal or state securities laws or
regulations. If at any time the Company shall determine, in its discretion, that
the listing, registration or qualification of any shares subject to an Award
upon any securities exchange or under any governmental regulatory body is
necessary or desirable as a condition of, or in connection with, the issuance or
purchase of shares hereunder, no shares of Stock may be issued or sold to the
Grantee or any other individual exercising an Option pursuant to such Award
unless such listing, registration, qualification, consent or approval shall have
been effected or obtained free of any conditions not acceptable to the Company,
and any delay caused thereby shall in no way affect the date of termination of
the Award. Specifically, in connection with the Securities Act, upon the
exercise of any Option or the delivery of any shares of Stock underlying an
Award, unless a registration statement under such Act is in effect with respect
to the shares of Stock covered by such Award, the Company shall not be required
to sell or issue such shares unless the Board has received evidence satisfactory
to it that the Grantee or any other individual exercising an Option may acquire
such shares pursuant to an exemption from registration under the Securities Act.
Any determination in this connection by the Board shall be final, binding, and
conclusive. The Company may, but shall in no event be obligated to, register any
securities covered hereby pursuant to the Securities Act. The Company shall not
be obligated to take any affirmative action in order to cause the exercise of an
Option or the issuance of shares of Stock pursuant to the Plan to comply with
any law or regulation of any governmental authority. As to any jurisdiction that
expressly imposes the requirement that an Option shall not be exercisable until
the shares of Stock covered by such Option are registered or are exempt from
registration, the exercise of such Option (under circumstances in which the laws
of such jurisdiction apply) shall be deemed conditioned upon the effectiveness
of such registration or the availability of such an exemption.

                                     - 11 -
<PAGE>

        12.2.   RULE 16b-3.

        During any time when the Company has a class of equity security
registered under Section 12 of the Exchange Act, it is the intent of the Company
that Awards pursuant to the Plan and the exercise of Options granted hereunder
will qualify for the exemption provided by Rule 16b-3 under the Exchange Act. To
the extent that any provision of the Plan or action by the Board does not comply
with the requirements of Rule 16b-3, it shall be deemed inoperative to the
extent permitted by law and deemed advisable by the Board, and shall not affect
the validity of the Plan. In the event that Rule 16b-3 is revised or replaced,
the Board may exercise its discretion to modify this Plan in any respect
necessary to satisfy the requirements of, or to take advantage of any features
of, the revised exemption or its replacement.

13.     EFFECT OF CHANGES IN CAPITALIZATION

        13.1.   CHANGES IN STOCK.

        If the number of outstanding shares of Stock is increased or decreased
or the shares of Stock are changed into or exchanged for a different number or
kind of shares or other securities of the Company on account of any
recapitalization, reclassification, stock split, reverse split, combination of
shares, exchange of shares, stock dividend or other distribution payable in
capital stock, or other increase or decrease in such shares effected without
receipt of consideration by the Company occurring after the Effective Date, the
number and kinds of shares for which grants of Options may be made under the
Plan shall be adjusted proportionately and accordingly by the Company. In
addition, the number and kind of shares for which Awards are outstanding shall
be adjusted proportionately and accordingly so that the proportionate interest
of the Grantee immediately following such event shall, to the extent
practicable, be the same as immediately before such event. Any such adjustment
in outstanding Options shall not change the aggregate Option Price payable with
respect to shares that are subject to the unexercised portion of an outstanding
Option, as applicable, but shall include a corresponding proportionate
adjustment in the Option Price per share. The conversion of any convertible
securities of the Company shall not be treated as an increase in shares effected
without receipt of consideration. Notwithstanding the foregoing, in the event of
any distribution to the Company's stockholders of securities of any other entity
or other assets (other than dividends payable in cash or stock of the Company)
without receipt of consideration by the Company, the Company may, in such manner
as the Company deems appropriate, adjust (i) the number and kind of shares
subject to outstanding Awards and/or (ii) the exercise price to reflect such
distribution.

                                     - 12 -
<PAGE>

        13.2.   REORGANIZATION IN WHICH THE COMPANY IS THE SURVIVING ENTITY
                WHICH DOES NOT CONSTITUTE A CORPORATE TRANSACTION.

        Subject to SECTION 13.3 hereof, if the Company shall be the surviving
entity in any reorganization, merger, or consolidation of the Company with one
or more other entities which does not constitute a Corporate Transaction, any
Option theretofore granted pursuant to the Plan shall pertain to and apply to
the securities to which a holder of the number of shares of Stock subject to
such Option would have been entitled immediately following such reorganization,
merger, or consolidation, with a corresponding proportionate adjustment of the
Option Price per share so that the aggregate Option Price thereafter shall be
the same as the aggregate Option Price of the shares remaining subject to the
Option immediately prior to such reorganization, merger, or consolidation.
Subject to any contrary language in an Award Agreement evidencing an Award, any
restrictions applicable to such Award shall apply as well to any replacement
shares received by the Grantee as a result of the reorganization, merger or
consolidation.

        13.3.   CORPORATE TRANSACTION.

                Subject to the exceptions set forth in the last sentence of this
SECTION 13.3 and the last sentence of SECTION 13.4 upon the occurrence of a
Corporate Transaction either of the following two actions shall be taken:

                        (A) fifteen days prior to the scheduled consummation of
a Corporate Transaction, all Options outstanding hereunder shall become
immediately exercisable and shall remain exercisable for a period of fifteen
days, or

                        (B) the Board may elect, in its sole discretion, to
cancel any outstanding Awards of Options pay or deliver, or cause to be paid or
delivered, to the holder thereof an amount in cash or securities having a value
(as determined by the Board acting in good faith), equal to the product of the
number of shares of Stock subject to the Option (the "Award Shares") multiplied
by the amount, if any, by which (I) the formula or fixed price per share paid to
holders of shares of Stock pursuant to such transaction exceeds (II) the Option
Price applicable to such Award Shares.

                With respect to the Company's establishment of an exercise
window, (i) any exercise of an Option during such fifteen-day period shall be
conditioned upon the consummation of the event and shall be effective only
immediately before the consummation of the event, and (ii) upon consummation of
any Corporate Transaction the Plan, and all outstanding but unexercised Options
shall terminate. The Board shall send written notice of an event that will
result in such a termination to all individuals who hold Options not later than
the time at which the Company gives notice thereof to its stockholders. This
SECTION 13.3 shall not apply to any Corporate Transaction to the extent that
provision is made in writing in connection with such Corporate Transaction for
the assumption or continuation of the Options theretofore granted, or for the
substitution for such Options of new common stock options relating to the stock
of a successor entity, or a parent or subsidiary thereof, with appropriate
adjustments as to the number of shares (disregarding any consideration that is
not common stock) and option, in which event the Plan and Options theretofore
granted shall continue in the manner and under the terms so provided.

                                     - 13 -
<PAGE>

        13.4.   ADJUSTMENTS.

        Adjustments under this SECTION 13 related to shares of Stock or
securities of the Company shall be made by the Board, whose determination in
that respect shall be final, binding and conclusive. No fractional shares or
other securities shall be issued pursuant to any such adjustment, and any
fractions resulting from any such adjustment shall be eliminated in each case by
rounding downward to the nearest whole share. The Board may provide in the Award
Agreements at the time of grant, or any time thereafter with the consent of the
Grantee, for different provisions to apply to an Award in place of those
described in SECTIONS 13.1, 13.2 and 13.3.

        13.5.   NO LIMITATIONS ON COMPANY.

        The making of Awards pursuant to the Plan shall not affect or limit in
any way the right or power of the Company to make adjustments,
reclassifications, reorganizations, or changes of its capital or business
structure or to merge, consolidate, dissolve, or liquidate, or to sell or
transfer all or any part of its business or assets.

14.     GENERAL PROVISIONS

        14.1.   DISCLAIMER OF RIGHTS

        No provision in the Plan or in any Award or Award Agreement shall be
construed to confer upon any individual the right to remain in the employ or
service of the Company or any Affiliate, or to interfere in any way with any
contractual or other right or authority of the Company either to increase or
decrease the compensation or other payments to any individual at any time, or to
terminate any employment or other relationship between any individual and the
Company. In addition, notwithstanding anything contained in the Plan to the
contrary, unless otherwise stated in the applicable Award Agreement, no Award
granted under the Plan shall be affected by any change of duties or position of
the Grantee, so long as such Grantee continues to be a director, officer,
consultant or employee of the Company or an Affiliate. The obligation of the
Company to pay any benefits pursuant to this Plan shall be interpreted as a
contractual obligation to pay only those amounts described herein, in the manner
and under the conditions prescribed herein. The Plan shall in no way be
interpreted to require the Company to transfer any amounts to a third party
trustee or otherwise hold any amounts in trust or escrow for payment to any
Grantee or beneficiary under the terms of the Plan.

        14.2.   NONEXCLUSIVITY OF THE PLAN

        The adoption of the Plan shall not be construed as creating any
limitations upon the right and authority of the Board to adopt such other
incentive compensation arrangements (which arrangements may be applicable either
generally to a class or classes of individuals or specifically to a particular
individual or particular individuals) as the Board in its discretion determines
desirable, including, without limitation, the granting of stock options
otherwise than under the Plan.

                                     - 14 -
<PAGE>

        14.3.   WITHHOLDING TAXES

        The Company or an Affiliate, as the case may be, shall have the right to
deduct from payments of any kind otherwise due to a Grantee any Federal, state,
or local taxes of any kind required by law to be withheld with respect to the
vesting of or other lapse of restrictions applicable to an Award or upon the
issuance of any shares of Stock upon the exercise of an Option or pursuant to an
Award. At the time of such vesting, lapse, or exercise, the Grantee shall pay to
the Company or the Affiliate, as the case may be, any amount that the Company or
the Affiliate may reasonably determine to be necessary to satisfy such
withholding obligation. Subject to the prior approval of the Company or the
Affiliate, which may be withheld by the Company or the Affiliate, as the case
may be, in its sole discretion, the Grantee may elect to satisfy such
obligations, in whole or in part, (i) by causing the Company or the Affiliate to
withhold shares of Stock otherwise issuable to the Grantee or (ii) by delivering
to the Company or the Affiliate shares of Stock already owned by the Grantee.
The shares of Stock so delivered or withheld shall have an aggregate Fair Market
Value equal to such withholding obligations. The Fair Market Value of the shares
of Stock used to satisfy such withholding obligation shall be determined by the
Company or the Affiliate as of the date that the amount of tax to be withheld is
to be determined. A Grantee who has made an election pursuant to this SECTION
14.3 may satisfy his or her withholding obligation only with shares of Stock
that are not subject to any repurchase, forfeiture, unfulfilled vesting, or
other similar requirements.

        14.4.   CAPTIONS

        The use of captions in this Plan or any Award Agreement is for the
convenience of reference only and shall not affect the meaning of any provision
of the Plan or such Award Agreement.

        14.5.   OTHER PROVISIONS

        Each Award granted under the Plan may contain such other terms and
conditions not inconsistent with the Plan as may be
determined by the Board, in its sole discretion.

        14.6.   NUMBER AND GENDER

        With respect to words used in this Plan, the singular form shall include
the plural form, the masculine gender shall include
the feminine gender, etc., as the context requires.

        14.7.   SEVERABILITY

        If any provision of the Plan or any Award Agreement shall be determined
to be illegal or unenforceable by any court of law in any jurisdiction, the
remaining provisions hereof and thereof shall be severable and enforceable in
accordance with their terms, and all provisions shall remain enforceable in any
other jurisdiction.

        14.8.   GOVERNING LAW

                                     - 15 -
<PAGE>

        The validity and construction of this Plan and the instruments
evidencing the Award hereunder shall be governed by the laws of the State of
Maryland, other than any conflicts or choice of law rule or principle that might
otherwise refer construction or interpretation of this Plan and the instruments
evidencing the Awards granted hereunder to the substantive laws of any other
jurisdiction.

                                      * * *

         To record adoption of the Plan by the Board as of December 20, 2001,
the Company has caused its authorized officer to execute the Plan.

                                           INFORMAX, INC.

                                           By:   /s/ JOHN M. GREEN
                                                 ---------------------------
                                           Name: John M. Green
                                           Title:Chief Operating Officer and
                                                 Chief Financial Officer

                                     - 16 -

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