Document:

AMENDMENT

     

    This
      Amendment (the “Amendment”) is made as of January 29, 2008 between Lixte
      Biotechnology Holdings, Inc., a Delaware corporation (“Lixte”), and Chem-Master
      International, Inc., a New York corporation (“Chem-Master”), with reference to
      the following:

     

    A. Pursuant
      to that certain Agreement dated as of February 5, 2007 (the “Agreement”)
      between Lixte and Chem-Master, Lixte engaged Chem-Master to synthesize certain
      organic compounds. Defined Terms not defined herein shall have the meaning
      ascribed to them in the Agreement.

     

    B. Lixte
      is
      desirous of extending the term of the Agreement and to expressly provide for
      the
      synthesis of the compound LB-3 as well as additional compounds not yet
      determined.

     

    NOW
      THEREFORE, in consideration of the premises and the mutual covenants set forth
      hereinafter, Chem-Master and Lixte agree to amend the Agreement as
      follows:

     

    ARTICLE
      I

     

    AMENDMENT

     

    1.1 Section
      1.2 is hereby amended by adding “and LB-3” after “LB-1” on the first line
      thereof.

     

    1.2 Article I
      is further amended by adding a new Section 1.6 as follows:

     

    “1.6 ‘LB-3’
      shall mean the compound having the physical properties set forth in Appendix
      B.”

     

    1.3 Article III
      is hereby amended by adding a new Section 3.3 and Section 3.4 as
      follows:

     

    “3.3 Within
      thirty days of the date hereof, Lixte shall issue to Chem-Master 100,000
      restricted shares (the “New Shares”) of the Common Stock of Lixte.

     

    “3.4 Lixte
      hereby grants to Chem-Master an option to purchase 200,000 shares of Common
      Stock of Lixte (the “New Options”) at an exercise price of $1.65 per share in
      two tranches. Provided that the Agreement is in force and effect at the time
      of
      the applicable vesting date, options to purchase 100,000 shares shall vest
      on
      August 1, 2009, and options to purchase the remaining 100,000 shares shall
      vest on February 1, 2011. Each tranche of the New Options may be
      exercisable for a period of two years from the date such tranche
      vests.”

     

    1.4 Section
      6.1 is hereby amended by substituting February 15, 2014 for ‘the second
      anniversary of the Effective Date’ on the second line thereof.”

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

    ARTICLE
      II

     

    REPRESENTATIONS
      OF CHEM-MASTER

     

    Chem-Master
      represents that the New Shares and New Warrants are being acquired by
      Chem-Master for investment purposes only and not with a view to distribution.
      Chem-Master acknowledges that the New Shares and New Warrants are restricted,
      the certificates for which will bear a customary legend, and may not be resold
      absent an applicable exemption under the securities laws.

    

     

    ARTICLE
      III

     

    EFFECT
      OF AMENDMENT

     

    Except
      as
      expressly provided in this Amendment, the Agreement remains in full force and
      effect:

     

    IN
      WITNESS WHEREOF, the parties have caused this Amendment to be executed as of
      the
      date set forth above.

     

    
      	LIXTE
              BIOTECHNOLOGY HOLDINGS, INC.	 	 	CHEM-MASTER
              INTERNATIONAL, INC.
	 	 	 	 
	By:
              /s/ JOHN
              S. KOVACH	 	 	By:
              /s/ FRANCIS JOHNSON
	
              

              Name: John
                S. Kovach

              Title: President

            	 	 	
              

              Name: Francis
                Johnson, Ph.D.

              Title: President

            

    

     

    
      
        
        

      

      
        2Exhibit 10.2

                             DRESSER-RAND GROUP INC.
                   GRANT NOTICE FOR 2008 STOCK INCENTIVE PLAN
                           NONQUALIFIED STOCK OPTIONS

FOR GOOD AND VALUABLE CONSIDERATION, Dresser-Rand Group Inc. (the "Company"),
hereby grants to Participant named below the nonqualified stock option (the
"Option") to purchase any part or all of the number of shares of its common
stock (the "Common Stock"), that are covered by this Option, as specified below,
at the Exercise Price per share specified below and upon the terms and subject
to the conditions set forth in this Grant Notice, the Dresser-Rand Group Inc.
2008 Stock Incentive Plan (the "Plan") and the Standard Terms and Conditions
(the "Standard Terms and Conditions") promulgated under such Plan, each as
amended from time to time. This Option is granted pursuant to the Plan and is
subject to and qualified in its entirety by the Standard Terms and Conditions.
The Standard Terms and Conditions may be accessed through Participant's personal
Smith-Barney Benefit Access account in the Plan Documents section.

---------------------------------------------- ---------------------------------

Name of Participant:
---------------------------------------------- ---------------------------------
Social Security Number:
---------------------------------------------- ---------------------------------
Grant Date:
---------------------------------------------- ---------------------------------
Number of Shares of Common Stock covered by
Option:
---------------------------------------------- ---------------------------------
Exercise Price Per Share:                      $
---------------------------------------------- ---------------------------------
Expiration Date:
---------------------------------------------- ---------------------------------
Vesting Schedule:
---------------------------------------------- ---------------------------------

This Option is not intended to qualify as an incentive stock option under
Section 422 of the Internal Revenue Code of 1986, as amended. By accepting this
Grant Notice, Participant acknowledges that he or she has received and read, and
agrees that this Option shall be subject to, the terms of this Grant Notice, the
Plan and the Standard Terms and Conditions.

DRESSER-RAND GROUP INC.
                                          --------------------------------------
                                                    Participant Signature
By
       ------------------------------
Title:                                    Address (please print):
       ------------------------------

                                          --------------------------------------

                                          --------------------------------------

                                          --------------------------------------

<PAGE>

                             DRESSER-RAND GROUP INC.
                        STANDARD TERMS AND CONDITIONS FOR
                       EMPLOYEE NONQUALIFIED STOCK OPTIONS

These Standard Terms and Conditions apply to any Options granted under the
Dresser-Rand Group Inc. 2008 Stock Incentive Plan (the "Plan"), which are
identified as nonqualified stock options and are evidenced by a Grant Notice or
an action of the Committee that specifically refers to these Standard Terms and
Conditions.

1.    TERMS OF OPTION

      Dresser-Rand Group Inc. (the "Company"), has granted to the Participant
      named in the Grant Notice provided to said Participant herewith (the
      "Grant Notice") a nonqualified stock option (the "Option") to purchase up
      to the number of shares of the Company's common stock (the "Common
      Stock"), set forth in the Grant Notice, at the purchase price per share
      and upon the other terms and subject to the conditions set forth in the
      Grant Notice, these Standard Terms and Conditions (as amended from time to
      time), and the Plan. For purposes of these Standard Terms and Conditions
      and the Grant Notice, any reference to the Company shall include a
      reference to any Subsidiary.

2.    NON-QUALIFIED STOCK OPTION

      The Option is not intended to be an incentive stock option under Section
      422 of the Internal Revenue Code of 1986, as amended (the "Code") and will
      be interpreted accordingly.

3.    EXERCISE OF OPTION

      The Option shall not be exercisable as of the Grant Date set forth in the
      Grant Notice. After the Grant Date, to the extent not previously
      exercised, and subject to termination or acceleration as provided in these
      Standard Terms and Conditions and the Plan, the Option shall be
      exercisable to the extent it becomes vested, as described in the Grant
      Notice, to purchase up to that number of shares of Common Stock as set
      forth in the Grant Notice provided that (except as set forth in Section
      4.A below) Participant remains employed with the Company and does not
      experience a termination of employment. The vesting period and/or
      exercisability of an Option may be adjusted by the Committee to reflect
      the decreased level of employment during any period in which the
      Participant is on an approved leave of absence or is employed on a less
      than full time basis, provided that the Committee may take into
      consideration any accounting consequences to the Company.

      To exercise the Option (or any part thereof), Participant shall deliver to
      the Company a "Notice of Exercise" on a form specified by the Committee,
      specifying the number of whole shares of Common Stock Participant wishes
      to purchase and how Participant's shares of Common Stock should be
      registered (in Participant's name only or in Participant's and
      Participant's spouse's names as community property or as joint tenants
      with right of survivorship).

<PAGE>

      The exercise price (the "Exercise Price") of the Option is set forth in
      the Grant Notice. The Company shall not be obligated to issue any shares
      of Common Stock until Participant shall have paid the total Exercise Price
      for that number of shares of Common Stock. The exercise price of may be
      paid in Common Stock, cash or a combination thereof, including an
      irrevocable commitment by a broker to pay over such amount from a sale of
      the Common Stock issuable under the Option, the delivery of previously
      owned Common Stock and withholding of Common Stock deliverable upon
      exercise.

      Fractional shares may not be exercised. Shares of Common Stock will be
      issued as soon as practical after exercise. Notwithstanding the above, the
      Company shall not be obligated to deliver any shares of Common Stock
      during any period when the Company determines that the exercisability of
      the Option or the delivery of shares hereunder would violate any federal,
      state or other applicable laws.

4.    EXPIRATION OF OPTION

      Except as provided in this Section 4, the Option shall expire and cease to
      be exercisable as of the Expiration Date set forth in the Grant Notice.

      A.    If the Participant's employment terminates by reason of death or
            Disability, the Participant (or the Participant's estate,
            beneficiary or legal representative) may exercise the Option
            (regardless of whether then vested or exercisable) until the earlier
            of (1) the twelve-month anniversary of the date of such termination
            of employment and (2) the Expiration Date.

      B.    If the Participant's employment terminates for any reason other than
            death, Disability or Cause, the Participant may exercise any Options
            that are vested and exercisable at the time of such termination of
            employment until the earlier of (A) the 90-day anniversary of the
            date of such termination of employment and (B) the Expiration Date.
            Any portion of the Option that is not vested and exercisable at the
            time of such a termination of employment shall be forfeited and
            canceled as of the date of termination of employment.

      C.    If the Participant's employment is terminated for Cause, the entire
            Option, whether or not then vested and exercisable, shall be
            immediately forfeited and canceled as of the date of such
            termination of employment.

5.    CHANGE IN CONTROL

      Unless otherwise provided in an employment, severance or other agreement
      between the Company and the Participant, the Committee shall determine the
      effect of a Change in Control on the Options. Without limitation, the
      Committee may provide for the acceleration of vesting and exercisability
      of any unvested Options, for a cash payment based on the Change in Control
      Price in settlement of the Options, or for the assumption or substitution
      of Options by the Participant's employer (or the parent or an Affiliate of
      such employer) that engages the Participant immediately following the
      Change in Control.

                                       2
<PAGE>

6.    RESTRICTIONS ON RESALES OF SHARES ACQUIRED PURSUANT TO OPTION EXERCISE

      The Company may impose such restrictions, conditions or limitations as it
      determines appropriate as to the timing and manner of any resales by the
      Participant or other subsequent transfers by the Participant of any shares
      of Common Stock issued as a result of the exercise of the Option,
      including without limitation (a) restrictions under an insider trading
      policy, (b) restrictions designed to delay and/or coordinate the timing
      and manner of sales by Participant and other optionholders and (c)
      restrictions as to the use of a specified brokerage firm for such resales
      or other transfers.

7.    INCOME TAXES

      The Company shall not deliver shares of Common Stock in respect of the
      exercise of any Option unless and until the Participant has made
      arrangements satisfactory to the Committee to satisfy applicable
      withholding tax obligations. Unless otherwise permitted by the Committee,
      withholding shall be effected by withholding Common Stock issuable in
      connection with the exercise of the Option. The Participant acknowledges
      that the Company shall have the right to deduct any taxes required to be
      withheld by law in connection with the exercise of the Options from any
      amounts payable by it to the Participant (including, without limitation,
      future cash wages).

8.    NON-TRANSFERABILITY OF OPTION

      The Participant may not assign or transfer the Option to anyone other than
      by will or the laws of descent and distribution and the Option shall be
      exercisable only by the Participant during his or her lifetime. The
      Company may cancel the Participant's Option if the Participant attempts to
      assign or transfer it in a manner inconsistent with this Section 8.

9.    THE PLAN AND OTHER AGREEMENTS

      In addition to these Terms and Conditions, the Option shall be subject to
      the terms of the Plan, which are incorporated into these Standard Terms
      and Conditions by this reference. Capitalized terms not otherwise defined
      herein shall have the meaning set forth in the Plan.

      The Grant Notice, these Standard Terms and Conditions and the Plan
      constitute the entire understanding between the Participant and the
      Company regarding the Option. Any prior agreements, commitments or
      negotiations concerning the Option are superseded.

                                       3
<PAGE>

10.   LIMITATION OF INTEREST IN SHARES SUBJECT TO OPTION

      Neither the Participant (individually or as a member of a group) nor any
      beneficiary or other person claiming under or through the Participant
      shall have any right, title, interest, or privilege in or to any shares of
      Common Stock allocated or reserved for the purpose of the Plan or subject
      to the Grant Notice or these Standard Terms and Conditions except as to
      such shares of Common Stock, if any, as shall have been issued to such
      person upon exercise of the Option or any part of it. Nothing in the Plan,
      in the Grant Notice, these Standard Terms and Conditions or any other
      instrument executed pursuant to the Plan shall confer upon the Participant
      any right to continue in the Company's employ or service nor limit in any
      way the Company's right to terminate the Participant's employment at any
      time for any reason.

11.   GENERAL

      In the event that any provision of these Standard Terms and Conditions is
      declared to be illegal, invalid or otherwise unenforceable by a court of
      competent jurisdiction, such provision shall be reformed, if possible, to
      the extent necessary to render it legal, valid and enforceable, or
      otherwise deleted, and the remainder of these Standard Terms and
      Conditions shall not be affected except to the extent necessary to reform
      or delete such illegal, invalid or unenforceable provision.

      The headings preceding the text of the sections hereof are inserted solely
      for convenience of reference, and shall not constitute a part of these
      Standard Terms and Conditions, nor shall they affect its meaning,
      construction or effect.

      These Standard Terms and Conditions shall inure to the benefit of and be
      binding upon the parties hereto and their respective permitted heirs,
      beneficiaries, successors and assigns.

      These Standard Terms and Conditions shall be construed in accordance with
      and governed by the laws of the State of Delaware, without regard to
      principles of conflicts of law.

      All questions arising under the Plan or under these Standard Terms and
      Conditions shall be decided by the Committee in its total and absolute
      discretion.

12.   ELECTRONIC DELIVERY

      By executing the Grant Notice, the Participant hereby consents to the
      delivery of information (including, without limitation, information
      required to be delivered to the Participant pursuant to applicable
      securities laws) regarding the Company and the Subsidiaries, the Plan, the
      Options and the Common Stock via Company web site or other electronic
      delivery.

                                       4

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