Document:

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                                                                    Exhibit 10.4

                             EMPLOYMENT AGREEMENT

     THIS AGREEMENT is made by and between Gen-Probe Incorporated, a Delaware
corporation ("EMPLOYER"), and Henry L. Nordhoff ("EMPLOYEE") as of June 17,
1994.

                               R E C I T A L S:

     WHEREAS, EMPLOYER and EMPLOYEE wish to set forth in this Agreement the
terms and conditions under which EMPLOYEE is to be employed by EMPLOYER.

     NOW, THEREFORE, EMPLOYER and EMPLOYEE, in consideration of the mutual
promises set forth herein, agree as follows:

                                  ARTICLE 1

                              TERM OF AGREEMENT

     1.1  Term. The term of this Agreement shall commence with EMPLOYEE's first
day of employment on July 5, 1994 and shall continue until terminated pursuant
to Article 6.

                                  ARTICLE 2

                              EMPLOYMENT DUTIES

     2.1  Title/Responsibilities. EMPLOYEE shall hold the positions of
President and Chief Executive Officer of EMPLOYER, and shall have the powers
and responsibilities consistent with such positions. Subject to the ultimate
direction and

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management of EMPLOYER's Board of Directors, EMPLOYEE will have general charge
of the day-to-day management and operations of EMPLOYER. EMPLOYEE shall also
perform all duties which from time to time are assigned to him by EMPLOYER's
Board of Directors, and shall provide the Board with periodic reports upon
request.

     2.2 Directorship. At the pleasure of EMPLOYER's stockholder(s), EMPLOYEE
agrees to serve as a Director on EMPLOYER's Board of Directors (and on such
Board committees to which he may be appointed) at no additional compensation.

     2.3 Full Time Attention. EMPLOYEE shall perform his duties hereunder in a
diligent and professional manner and devote substantially all of his business
time and attention, best efforts, energy and skills to EMPLOYER during the time
he is employed hereunder as President and Chief Executive Officer of EMPLOYER.
During the term of this Agreement EMPLOYEE shall not serve or act as a
shareholder (except passive holdings of less than 1% of the stock), employee,
agent, consultant, officer, director, partner, representative or owner of any
other business entity, nor (if it would require more than an insubstantial
amount of time or attention) of any non-profit entity other than Global Kids,
Inc..

     2.4 Compliance With Rules. EMPLOYEE shall comply with all applicable
governmental laws, rules and regulations and with all of EMPLOYER's policies,
rules and/or regulations applicable to the employees of EMPLOYER.

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                                   ARTICLE 3

                                  COMPENSATION

     3.1  Base Salary. EMPLOYER shall pay semi-monthly to EMPLOYEE a Base
Salary which may from time to time be increased (but not decreased) by
EMPLOYER's Board of Directors (or the Compensation Committee thereof). The
annual Base Salary for the first year of this Agreement shall be $300,000.
EMPLOYEE's initial annual salary review shall be on July 1, 1995 and thereafter
(beginning with calendar 1995) shall be at the end of the calendar year, in
accordance with EMPLOYER's timing of salary reviews for other officers.

     3.2  Bonus Compensation. In addition to the Base Salary provided above,
EMPLOYER's Board of Directors may, in its sole discretion, pay EMPLOYEE an
annual bonus pursuant to EMPLOYER's Executive Bonus Plan, as it may be amended
from time to time; provided, that EMPLOYEE's bonus for calendar 1994 shall be
$50,000.

     3.3  Relocation. In lieu of all other relocation expenses and signing
bonuses, EMPLOYER shall pay EMPLOYEE $100,000 (non-accountable) on his first
day of employment.

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                                   ARTICLE 4

                                FRINGE BENEFITS

     4.1  Plan Benefits. During the term of this Agreement, EMPLOYER agrees to
provide EMPLOYEE with health and life insurance through and in accordance with
its employee group health and life insurance plans as in effect from time to
time.

     4.2  Other Benefits. EMPLOYEE shall be entitled during the term of this
Agreement to all other fringe benefits made available from time to time by
EMPLOYER to its executives generally and/or its employees generally.

     4.3  Expenses. EMPLOYER shall reimburse EMPLOYEE, not less often than
monthly, for reasonable out-of-pocket business expenses incurred by EMPLOYEE in
the course of his duties hereunder, upon submission by EMPLOYEE of appropriate
expense account reports and substantiating receipts.

     4.4. Vacation. EMPLOYEE shall be entitled to paid vacation during the term
of this Agreement in accordance with EMPLOYER's vacation accrual plan and
policies (beginning at the 10-days-during-the-first-employment-year level).

     4.5  Life Insurance. EMPLOYER will obtain and pay for a term life
insurance policy providing for payment of $1,000,000 or, in EMPLOYER's sole
discretion, a greater amount, to EMPLOYEE's designated beneficiaries should
EMPLOYEE die during the term of this Agreement. (This policy shall be in
addition to coverage under EMPLOYER's group life insurance plan pursuant to
Section 4.1.)

     4.6  Disability Insurance. EMPLOYER will obtain and pay for a long-term
disability insurance policy providing for payment at a rate of no less than
$200,000

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per annum or, in EMPLOYER's sole discretion, a higher rate, to EMPLOYEE should
EMPLOYEE suffer a long-term disability during the term of this Agreement.

          4.7  AD&D Insurance. EMPLOYER will obtain and pay for an AD&D
insurance policy providing for a benefit to EMPLOYEE (or his beneficiaries) of
$400,000 (airplane) or $200,000 (automobile or walking) should EMPLOYEE suffer
accidental death or accidental disability during the term of this Agreement.

          4.8  Club. During the term of this Agreement, EMPLOYER will pay
EMPLOYEE's annual dues for membership in the Union League Club of New York City.

                                   ARTICLE 5

                               FORMER EMPLOYMENT

          5.1  No Conflict. EMPLOYEE represents and warrants that the execution
and delivery by him of this Agreement, his employment by EMPLOYER and his
performance of duties under this Agreement will not conflict with and will not
be constrained by any prior employment or consulting agreement or relationship,
or any other contractual obligation.

          5.2  No Use of Prior Confidential Information. EMPLOYEE will not
intentionally disclose to EMPLOYER or use on its behalf any confidential
information belonging to any of his former employers, but during his employment
by EMPLOYER he will use in the performance of his duties all information (but
only such information) which is generally known and used by persons with
training and experience comparable

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to his own or is common knowledge in the industry or otherwise legally in the
public domain.

                                   ARTICLE 6

                                  TERMINATION

          6.1  Cause for Termination. Notwithstanding anything to the contrary
herein, EMPLOYEE's employment and this Agreement shall terminate upon
EMPLOYEE's death and may also be terminated by EMPLOYER upon written
notification upon the occurrence of any of the following:

               a.   EMPLOYEE's permanent disability, which shall be defined as
EMPLOYEE's inability to perform, with or without reasonable accommodation, the
essential functions of his position for any 100 business days within any
continuous period of 200 days by reason of physical or mental illness or
incapacity.

               b.   EMPLOYEE being formally charged with the commission of a
felony, or being convicted of a misdemeanor involving moral turpitude.

               c.   EMPLOYEE's demonstrable fraud or dishonesty.

               d.   EMPLOYEE's use of alcohol, drugs or any illegal substance
in such a manner as to interfere with the performance of his duties under this
Agreement.

               e.   EMPLOYEE's intentional, reckless or grossly negligent
action detrimental to the best interest of the EMPLOYER, including any

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misappropriation or unauthorized use of EMPLOYER's property or improper
disclosure of confidential information (but excluding any good faith exercise of
business judgment).

          f.   EMPLOYEE's failure to perform material duties under this
Agreement if such failure has continued for 20 days after EMPLOYEE has been
notified in writing by EMPLOYER of the nature of EMPLOYEE's failure to perform.

          g.   EMPLOYEE's chronic absence from work for reasons other than
illness.

     In the event that EMPLOYEE's employment is terminated pursuant to this
Section 6.1 of this Agreement, EMPLOYER's obligations under this Agreement
shall immediately cease and EMPLOYEE will be entitled to no severance benefits
or any other benefits under this Agreement.

     Termination pursuant to this Section 6.1 shall be without prejudice to any
other right or remedy to which EMPLOYER may be entitled at law, in equity, or
under this Agreement.

     6.2  Termination For Other Than Cause. EMPLOYER may terminate EMPLOYEE's
employment and this Agreement at any time for any reason upon written
notification to EMPLOYEE. If EMPLOYER so terminates pursuant to this Section
6.2 (i.e., none of the matters specified in Section 6.1 has occurred), EMPLOYER
will pay EMPLOYEE the following severance benefit (and no more): (a) within
seven days after such termination of employment, a lump sum equal to the sum of
(i) six months' Base Salary (at its then level), plus (ii) an amount equal to
the amount EMPLOYEE would be required to pay under COBRA to continue his
EMPLOYER health insurance for six

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months; provided, that such lump sum shall be reduced by applicable tax
withholding; and (b) up to six monthly payments (each payable on the same day
of the month as such termination of employment, beginning with the seventh
month thereafter and continuing through the twelfth month, and each reduced by
applicable tax withholding) each equal to the sum of (i) one month's Base
Salary (at its level at the time of termination), plus (ii) an amount equal to
the amount EMPLOYEE would be required to pay under COBRA to continue his
EMPLOYER health insurance for one month; provided, however, that after EMPLOYEE
obtains other employment no severance benefits pursuant to this subsection (b)
shall be due or payable.

     6.3  No Severance Benefits Upon Resignation, Etc. EMPLOYEE will be
entitled to no severance benefits and EMPLOYER shall have no further
obligations under this Agreement if (a) EMPLOYEE resigns his employment during
the term of this Agreement for any reason (other than a material breach by
EMPLOYER of its obligations under this Agreement, in which case EMPLOYEE shall
be entitled to the severance benefits stated in Section 6.2), (b) EMPLOYER
terminates this Agreement and EMPLOYEE's employment upon the occurrence of any
of the matters specified in Section 6.1, or (c) EMPLOYEE dies during the term
of this Agreement.

                                   ARTICLE 7

                                  ARBITRATION

     7.1  Final and Binding Arbitration. Any controversy, claim or dispute
between (a) a party to this Agreement, on the one hand, and (b) the other party
to this

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Agreement and/or such second party's parents, subsidiaries or affiliates and/or
any of their directors, officers, employees, agents, successors, assigns, heirs,
executors, administrators, or legal representatives, on the other hand, arising
out of, in connection with, or in relation to (v) the interpretation, validity,
performance or breach of this Agreement, (w) EMPLOYEE's employment by EMPLOYER,
(x) any termination of such employment, (y) any claims for breach of contract or
breach of the covenant of good faith and fair dealing, or (z) any claims of
discrimination or other claims under any federal, state or local law or
regulation now in existence or hereinafter enacted and as amended from time to
time concerning in any way the subject of EMPLOYEE's employment with EMPLOYER or
its termination, shall, at the request of any party, be resolved to the
exclusion of a court of law by binding arbitration in San Diego, California, in
accordance with the Commercial Arbitration Rules of the American Arbitration
Association then in effect as expressly modified by this Article 7 (but
nonetheless the arbitration itself shall not be conducted under the auspices of
such Association unless the parties shall expressly so agree). The only claims
not covered by this Section 7.1 are claims for benefits under the workers'
compensation laws or claims for unemployment insurance benefits, which will be
resolved pursuant to those laws. Each of EMPLOYEE and EMPLOYER understands and
agrees that the arbitration shall be instead of any civil litigation and that
the arbitrator's decision shall be final and binding to the fullest extent
permitted by law and enforceable by any court having jurisdiction thereof.

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     7.2 Establishment of Forum. Arbitration shall be initiated by one party
sending to the other a Notice of Arbitration, by registered or certified United
States mail, which notice must contain a description of the dispute, the amount
involved, and the remedy sought. Unless the parties agree on one arbitrator
within ten days thereafter, a sole arbitrator shall be designated by the
American Arbitration Association. The arbitration shall be held within 90 days
after the mailing of the initiating notice, at a date, time and place determined
(subject to this Agreement) by the arbitrator.

     7.3 Pre-Hearing Conference. The arbitrator shall schedule a pre-hearing
conference to reach agreement or procedural matters, arrange for the exchange
of information, obtain stipulations, and attempt to narrow the issues.

     7.4 Discovery. The parties agree to expedite the arbitration proceedings by
eliminating discovery. Instead of discovery, the parties agree to the following
exchange of information:

         a. Either party can make a written demand for lists of the witnesses
to be called or the actual documents to be introduced at the hearing. The
demand must be received prior to the pre-hearing conference.

         b. The lists and such documents must be served within fifteen days of
the demand.

         c. Except as expressly provided in this Section 7.4, no depositions,
interrogatories, or document production may be taken for discovery.

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     7.5  The Hearing.

          a.   The parties must file briefs with the arbitrator at least three
days before the hearing, specifying the facts each intends to prove and
analyzing the applicable law.

          b.   The parties have the right to representation by legal counsel
throughout the arbitration proceedings.

          c.   Judicial rules of evidence and procedure relating to the conduct
at the hearing, examination of witnesses, and presentation of evidence do not
apply. Any relevant evidence, including hearsay, shall be admitted by the
arbitrator if it is the sort of evidence on which responsible persons are
accustomed to rely on in the conduct of serious affairs, regardless of the
admissibility of such evidence in a court of law.

          d.   Subject to the discretion of the arbitrator, both sides at the
hearing may call and examine witnesses for relevant testimony, introduce
relevant exhibits or other documents, cross-examine or impeach witnesses who
shall have testified orally on any matter relevant to the issues, and otherwise
rebut evidence.

          e.   Any party desiring a stenographic record may secure a court
reporter to attend the proceedings. The requesting party must notify the other
parties of the arrangements in advance of the hearing and must pay for the cost
incurred.

          f.   Any party may request the oral evidence to be given under oath.

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     7.6  The Award.

          a.   The decision shall be based on the evidence introduced at the
hearing, including all logical and reasonable inferences therefrom. The
arbitrator may grant any remedy or relief which is just and equitable. The
arbitrator shall be empowered to award relief which is legal and/or equitable
in nature, as appropriate.

          b.   The award must be made in writing and signed by the arbitrator.
It shall contain a concise statement of the reasons in support of the decision.

          c.   The award must be mailed promptly to the parties, but no later
than thirty (30) days from the closing of the hearing.

     7.7  Fees and Expenses. Each party must pay its pro rata share of the
arbitrator's expenses and fees, together with other expenses of the arbitration
incurred or approved by the arbitrator. Each party must pay its own attorney
fees, witness fees and other expenses incurred by the party for its own benefit.

     7.8  Special Limitations Period.  EMPLOYEE shall have ten days after
receipt of notification of termination pursuant to Article 6, or knowledge of
facts alleged to constitute some other breach of this Agreement, in which to
submit a demand for arbitration to EMPLOYER. If EMPLOYEE fails to submit a
demand for arbitration within said ten day period, such failure shall constitute
an absolute bar to EMPLOYEE's institution of any arbitration proceeding (or any
other kind of proceeding or court action) thereon.

     7.9  California Arbitration Statutes.  Except to the extent expressly
contradicted by this Agreement, the arbitration provisions of Section 1280 et
seq. (Part 3,

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Title 9) (with the exception of Section 1283.05) of the California Code of
Civil Procedure shall be fully applicable to this Agreement. For purposes of
California Code of Civil Procedure Section 1281.8 (relating to court issuance
of provisional remedies), the parties agree that in any controversy, claim or
dispute involving the protection of any intellectual property, it shall be
conclusively presumed, if a party is otherwise entitled to have a court issue a
provisional remedy, that the arbitration award to which the party may be
entitled may be rendered ineffectual without such provisional remedy.

     Except for applications or other procedures to obtain provisional relief
from a court as contemplated by California Code of Civil Procedure Section
1281.8 or any equivalent statute, if any controversy, claim or dispute within
the scope of this Article 7 becomes the subject of a judicial action and,
despite the other party's request for arbitration, for any reason remains the
subject of a judicial action, all decisions of fact and law shall be determined
by reference pursuant to Section 638 et seq. (Part 2, Title 8, Chapter 6) of the
California Code of Civil Procedure. The parties shall designate to the court as
referee a person determined by the parties in accordance with the provisions
established for the selection of an arbitrator pursuant to this Agreement; but
if an arbitrator is already selected pursuant to this Agreement the reference
shall be to such arbitrator.

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                                   ARTICLE 8

                               GENERAL PROVISIONS

     8.1       Governing Law. This Agreement and the rights of the parties
thereunder shall be governed by and interpreted under California law.

     8.2       Assignment. EMPLOYEE may not delegate, assign, pledge or
encumber his rights or obligations under this Agreement or any part thereof.

     8.3       Notice. Any notice required or permitted to be given under this
Agreement shall be sufficient if it is in writing and is sent by registered or
certified mail, postage prepaid, or personally delivered, to the following
addresses, or to such other addresses as either party shall specify by giving
notice under this section:

     TO EMPLOYER:        Chairman, Board of Directors
                         9880 Campus Point Drive
                         San Diego, CA 92121

         Copy to:        Hayden J. Trubitt
                         Brobeck, Phleger & Harrison
                         550 West C Street, Suite 1300
                         San Diego, CA 92101

 TO THE EMPLOYEE:        Henry L. Nordhoff
                         41 Little Brook Road
                         Wilton, CT 06897

     8.4       Amendment. This Agreement may be waived, amended or supplemented
only by a writing signed by both of the parties hereto. To be valid, EMPLOYER's
signature must be by a person specially authorized by EMPLOYER's Board of
Directors to sign such particular document.

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     8.5  Waiver. No waiver of any provision of this Agreement shall be binding
unless and until set forth expressly in writing and signed by the waiving party.
To be valid, EMPLOYER's signature must be by a person specially authorized by
EMPLOYER's Board of Directors to sign such particular document. The waiver by
either party of a breach of any provision of this Agreement shall not operate or
be construed as a waiver of any preceding or succeeding breach of the same or
any other term or provision, or a waiver of any contemporaneous breach of any
other term or provision, or a continuing waiver of the same or any other term or
provision. No failure or delay by a party in exercising any right, power, or
privilege hereunder or other conduct by a party shall operate as a waiver
thereof, in the particular case or in any past or future case, and no single or
partial exercise thereof shall preclude the full exercise or further exercise of
any right, power, or privilege. No action taken pursuant to this Agreement shall
be deemed to constitute a waiver by the party taking such action of compliance
with any representations, warranties, covenants or agreements contained herein.

     8.6  Severability. All provisions contained herein are severable and in the
event that any of them shall be held to be to any extent invalid or otherwise
unenforceable by any court of competent jurisdiction, such provision shall be
construed as if it were written so as to effectuate to the greatest possible
extent the parties' expressed intent; and in every case the remainder of this
Agreement shall not be affected thereby and shall remain valid and enforceable,
as if such affected provision were not contained herein.

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     8.7  Headings. Article and section headings are inserted herein for
convenience of reference only and in no way are to be construed to define, limit
or affect the construction or interpretation of the terms of this Agreement.

     8.8  Drafting Party. The provisions of this Agreement have been prepared,
examined, negotiated and revised by each party hereto, and no implication shall
be drawn and no provision shall be construed against either party by virtue of
the purported identity of the drafter of this Agreement, or any portion thereof.

     8.9  Entire Agreement. This Agreement, together with the Proprietary
Information and Inventions Agreement, constitutes the entire agreement between
the parties pertaining to the subject matter hereof and completely supersedes
all prior or contemporaneous agreements, understandings, arrangements,
commitments, negotiations and discussions of the parties, whether oral or
written (all of which shall have no substantive significance or evidentiary
effect). (The parties agree that the Confidential Disclosure Agreement dated
June 2, 1994 shall not be superseded hereby.) Each party acknowledges,
represents and warrants that he or it has not relied on any representation,
agreement, understanding, arrangement or commitment which has not been expressly
set forth in this Agreement. Each party acknowledges, represents and warrants
that this Agreement is fully integrated and not in need of parol evidence in
order to reflect the intentions of the parties. The parties specifically intend
that the literal words of this Agreement shall, alone, conclusively determine
all questions concerning the parties' intent.

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     IN WITNESS WHEREOF, the parties have executed and delivered this Employment
Agreement in San Diego, California as of the date first written above.

                                        GEN-PROBE INCORPORATED

                                        By:  /s/
                                            ------------------------------------
                                            Chief Operating Officer

                                        /s/        HENRY L. NORDHOFF
                                        ----------------------------------------
                                                   HENRY L. NORDHOFF

                                      -17-<PAGE>
                                                                    Exhibit 10.5

     1.   If, at any time during the first twelve months of your employment by
the Company, the Company terminates your employment following a Change in
Control or for reasons other than Cause, or if you terminate your employment
following a Change in Control for Good Reason, you will be entitled to receive
from the Company the following severance benefits, in lieu of all other salary
and benefits:

          a.   CONTINUED COMPENSATION. The Company will pay you your base salary
     at the rate in effect at the time of the termination of your employment,
     for a period of six months following the termination date, or until you
     obtain other full-time employment, whichever is sooner.

          b.   HEALTH CARE AND LIFE INSURANCE COVERAGE. The Company will provide
     continued health care coverage under the Company's medical plan, without
     charge, to you and your eligible dependents until the earlier of (i) six
     months following the termination date or (ii) the first date that you are
     covered under another employer's health benefit program providing
     substantially the same or better benefit options without exclusion for any
     pre-existing medical condition. The period of time medical coverage
     continues under this agreement will be counted as coverage time under
     COBRA.

     A "Change in Control" shall occur if any person or related group of persons
(other than the Company or a person that, prior to such transaction, directly or
indirectly controls, is controlled by, or is under common control with, the
Company) directly acquires beneficial ownership of securities possessing more
than fifty percent (50%) of the total combined voting power of the Company's
outstanding securities.

     "Cause" means any of the following events: (i) any act of gross or willful
misconduct, fraud, misappropriation, dishonesty, embezzlement or similar conduct
on your part; (ii) your conviction of a felony or any crime involving moral
turpitude (which conviction, due to the passage of time or otherwise, is not
subject to further appeal); (iii) your misuse or abuse of alcohol, drugs or
controlled substances and failure to seek and comply with appropriate treatment;
or (iii) your becoming disabled such that you are not able to performing your
usual duties for the Company for a period in excess of six (6) consecutive
calendar months.

     "Good Reason" means any of the following events, if you have not consented
thereto: (i) a substantial diminution in your duties and responsibilities
hereunder; (ii) the Company headquarters are moved more than 30 miles from its
present location in San Diego, California; (iii) a material reduction in your
base salary or benefits from the Company, other than in connection with an
across-the-board reduction for all similarly situated employees; provided,
however, that no change in ownership or control of the Company shall itself
constitute Good Reason; and provided, further, that an insubstantial and
inadvertent action which is remedied by the Company promptly after receipt of
notice thereof given by you shall not constitute Good Reason hereunder. Your
consent to any event which would otherwise constitute Good Reason shall be
conclusively

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presumed if you do not exercise your rights to terminate your employment for
Good Reason under this section within sixty (60) days of the event.

     2.   Any and all compensation to be paid under this agreement will be
subject to the Company's collection of all applicable federal, state and local
income and employment withholding taxes.

     3.   Nothing in this agreement shall be construed as giving you any rights
to continued employment with the Company, and the Company shall continue to
have the right to terminate your employment at any time, with or without cause,
subject to the provisions of this Agreement.

     /s/ Herm Rosenman            /s/ Robin L. Vedova
     -----------------            -------------------
     Herm Rosenman                Robin L. Vedova

     5/24/01                       5/24/01
     --------------                --------------
     Date                          Date

                                       2

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