Document:

EXHIBIT
      10.2

    

    AMENDMENT
      NO. 1 

     

    TO
      

     

    SECURED
      PROMISSORY NOTE

     

    This
      Amendment No. 1 to Secured Promissory Note (the “Amendment”)
      is
      made effective as of October 31, 2008 (the “Amendment
      Date”)
      and is
      entered into by and between Paradigm Holdings, Inc., a Wyoming corporation
      (the
“Company”),
      and
      Theresa Kleszewski (the “Lender”).
      

    

    Capitalized
      terms used in this Amendment that are not otherwise defined herein shall have
      the meanings set forth in the Note (as defined below).

    

    Whereas,
      the
      Company and the Lender are parties to that certain Secured Promissory Note
      dated
      April 9, 2007 in the original principal amount of $4,000,000 (the “Note”);

    

    Whereas,
      the Note
      provides that the Remainder Amount plus any and all interest accrued thereon
      shall be due and payable on October 31, 2008 (the “Maturity
      Date”); 

    

    Whereas,
      the
      Company desires to extend the Maturity Date and the Lender is willing to extend
      the Maturity Date in exchange for the consideration described herein;
      and

    

    Whereas, the
      Note
      may be amended by a writing executed by the Company and the Lender.

    

    Now,
      Therefore,
      in
      consideration of the mutual covenants and obligations set forth herein, and
      for
      other good and valuable consideration, the receipt and sufficiency of which
      is
      hereby acknowledged, the Lender and the Company hereby agree as
      follows:

    

    
      
        	1.	
                Payment.

              

      

    

    

    In
      consideration of the Lender’s signing of this Amendment, the Company shall pay
      $20,000.00 to each of the Lender and Christian Kleszewski. The Company shall
      also pay the accrued interest to the Lender under the Note for the period
      commencing on October 1, 2008 and ending on November 5, 2008 in the amount
      of
      $13,978.31, which amount shall be divided between the Lender and Christian
      Kleszewsk pursuant to Section
      3.3
      of this
      Amendment.

    

    
      
        	2.	
                Amendment
                  of the Agreement.

              

      

    

    

    The
      parties hereby agree to amend the terms of the Note as of the Amendment Date
      as
      provided below.

    

    2.1 Amendment
      of Section 2.
      Section
      2 of the Note is hereby amended and restated in its entirety to read as
      follows:

    

    “2. Maturity.
      The
      Remainder Amount of this Note plus any and all interest accrued hereon shall
      be
      due and payable on December 15, 2008 (the “Maturity
      Date”)
      or as
      otherwise set forth herein.” 

    

    2.2 Amendment
      of Section
      5.
      The
      third sentence from the end of Section 5 is hereby amended and restated in
      its
      entirety to read as follows:

    

    “In
      addition, the Company shall pay to the Lender a late charge equal to five
      percent (5%) of any amount currently due hereunder that is not received by
      the
      Lender within five (5) days after the date on which such amount is due;
      provided, however, that this provision shall not be construed to extend the
      due
      date for any amount required to be paid hereunder and provided, further that
      this provision shall not apply with respect to a failure to pay the Remainder
      Amount by the Maturity Date.” 

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

    

    

    2.3 Amendment
      of Section 5.
      The
      following sentence is hereby added at the end of Section 5 of the
      Note:

    

    “Notwithstanding
      the foregoing, a failure by the Company to pay the Remainder Amount on or before
      the Maturity Date (a “Missed
      Deadline”)
      shall
      not constitute a Default under this Note. In the event of a Missed Deadline,
      the
      Company shall pay, in immediately available funds, an amount equal to $60,000
      plus all accrued and unpaid interest through the Maturity Date to the Lender.
      After a Missed Deadline, interest shall accrue, at a rate equal to twelve
      percent (12%) per annum, on the outstanding amounts due hereunder until such
      amounts are paid, unless otherwise limited by law. In no event shall interest
      payable on the outstanding amounts due hereunder exceed twelve percent (12%)
      per
      annum.” 

    

    3. Miscellaneous.

    3.1 No
      Other Changes.
      All
      terms of the Note shall remain in full force and effect as amended
      hereby.

    

    3.2 Governing
      Law.
      This
      Amendment shall be governed in all respects by the internal laws of the State
      of
      Maryland as applied to agreements entered into among Maryland residents to
      be
      performed entirely within Maryland, without regard to principles of conflicts
      of
      law.

    

    3.3 Payment
      Acknowledgement.
      The
      Lender hereby directs the Company to pay one-half (1/2) of all amounts otherwise
      payable to the Lender under the Note to Christian Kleszewski.

    

    3.4 Counterparts.
      This
      Amendment may be executed in counterparts and signatures may be delivered by
      facsimile, each of which shall be deemed an original, but both of which together
      shall constitute one and the same instrument.

    

    [Signature
      Page Follows]

    

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

    In
      Witness Whereof,
      the
      parties have caused this Amendment No. 1 to Secured Promissory Note to be
      executed by the undersigned as of the date hereof.

     

    
      	 	 	 
	 	
              COMPANY:

               

              PARADIGM HOLDINGS,
                INC.

            
	 
 	 
 	 
 
	
            	By:  	/s/ Peter B. LaMontagne
	 	
              
Peter
              B. LaMontagne
	 	President
              and
              Chief Executive Officer

      	 	 	 
	 	
              LENDER:

               

              THERESA
                KLESZEWSKIBacillus
      Calmette-Guerin
      Vaccine Transfer Agreement

    

    Project
      Name: Bacillus Calmette-Guerin Vaccine

    Transferee
      (Party A): Guangzhou Konzern Pharmaceutical Co., LTD

    Transferor
      (Party B): Hongyuan Pharmaceutical Technology Consulting Service Center of
      Yuexiu District of Guangzhou

    Date
      of
      contract: May 8, 2008

    Place
      of
      contract: Guangzhou

    Validity
      Period: May 2008-May 2010

    

    Agreement
      of Technology Transfer for the Patent with Exclusive Use
      Permit

    

    Transferee
      (Party A): Guangzhou Konzern Pharmaceutical Co., LTD

    Transferor
      (Party B): Hongyuan Pharmaceutical Technology Consulting Service Center of
      Yuexiu District of Guangzhou

    

    Under
      this agreement, Party B exclusively permits Party B to use the Bacillus
      Calmette-Guerin Vaccine (hereinafter referred to as BCG Vaccine) whose patent
      is
      owned by Party B, and Party A obtains the exclusive use permit from Party B
      and
      pay Party B the fee for exclusive use permit. On the base of fair negotiation
      and full understanding to the terms and conditions, in accordance with the
      Contract Law of the PRC, both parties agree and are bound by as
      follows:

    

    Article
      1 Under
      this agreement, the patent with exclusive use permit is:

    
      	
              i.

            	
              biotechnology
                patent;

            

    

    
      	
              ii.

            	
              invited
                or developed by Guangdong Institute of Biological Products; and
                

            

    

    
      	
              iii.

            	
              owned
                by Hongyuan Pharmaceutical Technology Consulting Service Center of
                Yuexiu
                District of Guangzhou

            

    

    

    Article
      2 Before
      this agreement comes into effect, with respect to the patent with Exclusive
      Use
      Permit, Party B agrees that:

    
      	
              i.

            	
              the
                transfer of patent herein is conducted in Guangzhou; and
                

            

    

    
      	
              ii.

            	
              Party
                B will not transfer the patent herein to any person or company other
                than
                Party A.

            

    

    

    Article
      3
      With
      respect to the pattern, scope and term of the patent herein, Party B agrees
      that:

    
      	
              i.

            	
              pattern
                of use: Party B permits Party A to use the patent herein with Party
                A’s
                discretion;

            

    

    
      	
              ii.

            	
              scope
                of use: nationwide; and

            

    

    
      	
              iii.

            	
              term
                of use: perpetual use.

            

    

     

    
      
         

      

      
         

        
          

        

      

      
         

      

    

     

    Article
      4 To
      secure
      the effective use of Party A, Party B should provide Party A with the following
      materials and information:

    
      	
              i.

            	
              certificate
                of new drug;

            

    

    
      	
              ii.

            	
              craft
                and technology for mass production;
                and

            

    

    
      	
              iii.

            	
              clinical
                direction and instruction.

            

    

    

    Article
      5
      Party B
      should submit the materials and information set forth in Article 4 of this
      agreement according to following conditions:

    
      	
              i.

            	
              time
                of submission: Party B submits the materials for Party A’s evaluation upon
                the receipt of deposit of RMB 5million from Party
                A;

            

    

    
      	
              ii.

            	
              place
                of submission: Guangzhou; and

            

    

    
      	
              iii.

            	
              form
                of submission: in written form.

            

    

    

    Article
      6
      To
      secure the effective use of Party A, Party B should forward the technical secret
      of the patent herein according to the following conditions:

    
      	
              i.

            	
              content
                of technical secret: BCG Vaccine;

            

    

    
      	
              ii.

            	
              requirement
                of use the technical secret hereunder: limit to persons or employees
                of
                both parties; and

            

    

    
      	
              iii.

            	
              scope
                and term of non-disclosure of technical secret hereunder:
                perpetual.

            

    

    

    Article
      7
      To
      secure the effective use of Party A, Party B should provide the following
      technical service and instructions:

    
      	
              i.

            	
              content
                of the technical service and instructions hereunder: design of clinical
                plan and craft and technology for mass production;
                and

            

    

    
      	
              ii.

            	
              form
                of providing the technical service and instructions hereunder: consult
                service and on-the-spot
                instructions.

            

    

    

    Article
      8
      Both
      parties agree that Party B permits Party A to use the technical secrets and
      provides Party A with the technical service and instructions according to the
      following standard and form:

    
      	
              i.

            	
              in
                consistent with the requirement for biological products set forth
                by State
                Food and Drug Administration of China;
                and

            

    

    
      	
              ii.

            	
              sufficient
                to obtain the manufacturing
                license.

            

    

    

    Article
      9
      Party A
      pay the fee for exclusive use permit to Party B according to the following
      conditions:

    
      	
              i.

            	
              total
                amount of the fee for exclusive use permit is RMB 30million, and
                specially
                the fee for technical secret is RMB 20million and fee for technical
                service and instruction is RMB 10million;
                and

            

    

    
      	
              ii.

            	
              Party
                A pay the fee hereunder to Party B by stages and the payment schedule
                is
                as follows:

            

    

    
      	
              (i.)

            	
              Party
                should pay deposit amounted RMB 5million to Party B within 10 business
                days. When the evaluation results fail to meet the expectation agreed
                by
                both parties (the actual value is 10% higher or lower than RMB 40million),
                Party A is entitled to cancel this project and Party should fully
                return
                the deposit amounted RMB 5million to Party B within 5 business days.
                When
                the evaluation results meet the expectation agreed by both parties,
                Party
                A should pay Party B RMB0.2million if Party decides to cancel the
                project;

            

    

    
    

     

    
      
         

      

      
        2

        
          

        

      

      
         

      

    

     

    
      	
              (ii.)

            	
              Party
                B should cooperate with Party A to conduct the evaluation upon the
                receipt
                of the deposit hereunder;

            

    

    
      	
              (iii.)

            	
              Upon
                the completion of evaluation, Party A should pay RMB 1million to
                Party B
                and Party B starts transferring the materials and information to
                Party A;
                and

            

    

    
      	
              (iv.)

            	
              Upon
                the receipt of certificate of new drug, Party A pay RMB10million
                to Party
                B.

            

    

    

    Article
      10
      Party B
      promises that the use of patent herein does not constitute an infringement
      upon
      the lawful right of the third party. Should the infringement hereunder occur,
      Party B should participate in the lawsuit until the third party cancels the
      charge.

    

    Article
      11
      Party B
      should maintain the validity of the patent herein within the term of this
      agreement. Should the validity of the patent herein terminate due to the fault
      or negligence of Party B, Party B should pay the damages or compensation to
      Party A in accordance with Article 16 of this agreement.

    

    If
      the
      patent is deem as void and invalid by the state administration which governs
      patent issue, Party B should compensate for the loss to Party A. The proportion
      of the fee for exclusive use permit paid to Party B is nonrefundable. Party
      B
      should fully return the deposit paid by Party A.

    

    Article
      12
      Party A
      should start the project herein within 10 days from the effective date of this
      agreement. Party A should effectively inform Party B of any delay of the
      implementation of the project herein, provide explanation for the delay
      hereunder and obtain the permit of the aforesaid delay from Party B. If Party
      A
      fails to provide the explanation hereunder, which may affect the benefit of
      Party B in this Project, Party B is entitled to claim the damages and
      compensation from Party A.

    

    Articles
      13
      With
      respect to the performance of this agreement, both parties agree that no
      contracting party may prevent the other contracting party to cooperating with
      the third party for the purpose of technology development.

    

    Article
      14
      Both
      parties agree that:

    
      	
              i.

            	
              Party
                A is entitled to use the patent technology and technical secret for
                the
                purpose of the further improvement. The new technical outcome with
                material or innovative characteristics from the further improvement
                hereunder is owned by Party A; and

            

    

    
      	
              ii.

            	
              Party
                B is entitled to improve the patent technology and technical secret
                after
                transfer the patent to Party A. The new technical outcome with material
                or
                innovative characteristics from the further improvement hereunder
                is owned
                by Party B.

            

    

     

    
      
         

      

      
        3

        
          

        

      

      
         

      

    

     

    Article
      15 Any
      alteration of this agreement should be made through the consent of both parties
      and finalized in written form. If one party hereto request for the alteration
      regarding the right and obligations in the agreement, the other party hereto
      should response within 15 days. Any delay or non-reply is deem as approval
      of
      the alteration hereunder.

    

    Article
      16 Both
      parties agree on the compensation of the breach of this agreement. Any party
      hereto who breach any article herein should pay the damages amounted RMB
      0.5million.

    

    Article
      17
      Within
      the validity term of this agreement, both parties agree that Ms Minhua Liu
      is
      the respondent of Party A and Ms Li Wen is the respondent of Party
      B.

    

    Any
      change of the respondent should be notified in written form. The party who
      fail
      to notify the change hereunder should be liable for any loss arising from the
      delay or non-notification of the change hereunder.

    

    Article
      18
      Both
      parties agree to cancel this agreement in the occurrence of the following
      situations which make the performance of this agreement impossible:

    
      	
              i.

            	
              Force
                Majeure; and

            

    

    
      	
              ii.

            	
              the
                change of Regulation on Biological Product Registration of PRC and
                other
                laws.

            

    

    

    Article
      19
      In the
      occurrence of the dispute arising from this agreement, both parties should
      settle the dispute through negotiation and meditation first. Should the
      aforesaid attempt to settle dispute fail, party hereto may settle the dispute
      through:

    
      	
              i.

            	
              arbitration;
                or

            

    

    
      	
              ii.

            	
              filing
                a lawsuit in People’s Court.

            

    

    

    Article
      20
      Parties
      here to have set forth no definition of terms in this agreement.

    

    Article
      21
      Both
      parties confirm the materials and documents in connection with this agreement
      by
      signature. Altogether, there are 2-page background materials and 10-page
      documents regarding the original design and craft.

    

    Article
      22 Parties
      hereto have no further requirements in this agreement.

    

    Article
      23 This
      agreement is made in duplicate and both copy have same legal force.

    

    Article
      24
      This
      agreement shall become effective upon and from the date on which it is signed
      and sealed.

     

    
      
         

      

      
        4

        
          

        

      

      
         

      

    

     

    

    Party
      A:
      Guangzhou Konzern Pharmaceutical Co., LTD

    Representative:
      Ms Minhua Liu

    Date:
      May
      8, 2008

    

    Party
      B:
      Hongyuan Pharmaceutical Technology Consulting Service Center of Yuexiu District
      of Guangzhou

    Representative:
      Ms Yanli Gu

    Date:
      June 1, 2008

     

    
      
         

      

      
        5

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