Document:

EX-10.3

 Exhibit 10.3 

DP160071 
 Jason Kim 

 
 

 
  
 

 
 STATE OF TEXAS 
 COUNTY OF
TRAVIS 
 This CANCER RESEARCH GRANT CONTRACT (“Contract”) is by and between the Cancer Prevention and Research Institute of
Texas (“CPRIT”), hereinafter referred to as the “INSTITUTE”, acting through its Chief Executive Officer, and Molecular Templates, Inc., hereinafter referred to as the
“RECIPIENT”, acting through its authorized signing official. 
 RECITALS 

WHEREAS, pursuant to TEX. HEALTH & SAFETY CODE, Ch. 102, the INSTITUTE may make grants to public and private persons in this state for research into
the causes and cures for all types of cancer in humans; facilities for use in research into the causes and cures for cancer; research to develop therapies, protocols, medical pharmaceuticals, or procedures for the cure or substantial mitigation of
all types of cancer; and cancer prevention and control programs. 
 WHEREAS, Article III, Section 67 of the Texas Constitution expressly authorizes the
State of Texas to sell general obligation bonds on behalf of the INSTITUTE and for the INSTITUTE to use the proceeds from the sale of the bonds for the purposes of cancer research and prevention programs in this state. 

WHEREAS, the INSTITUTE issued a request for applications for RFA P-16-TXCO-2: Texas Company Product Development Research Awards on or about January 2016. 
 WHEREAS,
pursuant to TEX. HEALTH & SAFETY CODE § 102.251, and after a review by the INSTITUTE’s scientific research and prevention program committees, the INSTITUTE has approved a Grant (defined below) to be awarded to the RECIPIENT. 

WHEREAS, to ensure that the Grant provided to the RECIPIENT pursuant to this Contract is utilized in a manner consistent with “Tex. Const. Article III,
Section 67 and other laws, and in exchange for receiving such Grant, the RECIPIENT agrees to comply with certain conditions and deliver certain performance. 

WHEREAS, the RECIPIENT and the INSTITUTE desire to set forth herein the provisions relating to the awarding of such monies and the disbursement thereof to the
RECIPIENT. 
 IN CONSIDERATION of the Grant and the premises, covenants, agreements, and provisions contained in this Contract, the parties agree to
the following terms and conditions: 
 Article I 

DEFINITIONS 
 The following terms shall
have the following meaning throughout this Contract and any Attachments and amendments. Other terms may be defined elsewhere in this Contract. 

(1)    Collaborator—any entity other than the RECIPIENT having one or more personnel participating in the
Project and (a) designated as a collaborator in the application submitted by the RECIPIENT requesting the Grant funds awarded by the INSTITUTE, or (b) otherwise approved in writing as a collaborator by the INSTITUTE. 

  
 1 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 DP160071 

Jason Kim 
  

 (2)    Contractor—any person or entity, other than a
Collaborator or the RECIPIENT (or their respective personnel), who is contracted by the RECIPIENT to perform activities for the Project. 

(3)    Equipment—an article of tangible, nonexpendable personal property having a useful life of more than one
year and an acquisition cost of $5,000 or more per unit. 
 (4)    Grant—the funding assistance authorized by
TEX. HEALTH & SAFETY CODE, Ch. 102 in the amount specified in Section 2.01 and awarded by the INSTITUTE to the RECIPIENT to carry out the Project pursuant to the terms and conditions of this Contract. 

(5)    Indirect Costs—the expenses of doing business that are not readily identified with a particular grant,
contract, project, function or activity, but are necessary for the general operation of the organization or the performance of the organization’s activities. 

(6)    Institute-Funded Activity—all aspects of work conducted on or as part of the Project. 

(7)    Non-Profit Organization—a university or other institution of
higher education or an organization of the type described in 501(c)(3) of the Internal Revenue Code of 1986, as amended (26 U.S.C. 501 (c)(3)) and exempt from taxation under 501 (a) of the Internal Revenue Code (26 U.S.C. 501 (a)) or any nonprofit
scientific or educational organization qualified under a state nonprofit organization statute. 
 (8)    Principal
Investigator/Program Director—the individual designated by the RECIPIENT to direct the Project who is principally responsible and accountable to the RECIPIENT and the INSTITUTE for the proper conduct of the Project. References herein to
“Principal Investigator/Program Director” include Co-Principal Investigators or Co-Program Directors as well. The Principal Investigator/Program Director and Co-Principal Investigators or Co-Program Directors are set forth on Attachment A. 

(9)    Project—the activities specified or generally described in the Scope of Work or otherwise in this
Contract (including without limitation any of the Attachments to the Contract) that are approved by the INSTITUTE for funding, regardless of whether the INSTITUTE funding constitutes all or only a portion of the financial support necessary to carry
them out. 
 (10)    Recipient Personnel—The RECIPIENT’s Principal Investigator/Program Director and
RECIPIENT’s employees and consultants working on the Project. 
 Article II 

GRANT AWARD 

Section 2.01    Award of Monies. In accordance with the provisions of this Contract and any applicable
agency administrative rules, the INSTITUTE shall disburse the proceeds of the Grant to the RECIPIENT in an amount not to exceed $ 15,200,000 to be used solely for the Project. This award is subject to compliance with the Scope of Work and
demonstration of progress towards achievement of the milestones set forth in Section 2.02. This Grant is not intended to be a loan of money. 

Section 2.02    Scope of Work and Milestones. The RECIPIENT shall perform the Project in accordance with
this Agreement and as outlined in Application DP160071 submitted by the RECIPIENT and approved by the INSTITUTE. The RECIPIENT shall conduct the Project within the State of Texas with Texas-based employees, Contractors and/or Collaborators
unless otherwise specified in the Scope of Work or the Approved Budget. The INSTITUTE and the RECIPIENT hereby adopt the terms of Attachment A in their entirety, incorporate them as if fully set forth herein, and agree that the Project description,
goals, timeline and milestones included as Attachment A accurately reflect the Scope of Work of the Project to be undertaken by the RECIPIENT (the “Scope of Work”) and the milestones expected to be achieved. RECIPIENT and the
INSTITUTE mutually agree that the outcome of scientific research is unpredictable and cannot be guaranteed. The RECIPIENT shall use commercially reasonable efforts to complete the goals of the Project pursuant to the timeline reflected in Attachment
A and shall timely notify 

  
 2 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 DP160071 

Jason Kim 
  

 
the INSTITUTE if circumstances occur that materially and adversely affect completion thereof. Modifications, if any, to the Scope of Work must be agreed to in writing by both parties as set forth
in Section 2.06 “Amendments and Modifications” herein. Material changes to the Scope of Work include, but are not limited to, changes in key personnel involved with the Project, the site of the Project, and the milestones expected to
be achieved. 
 Section 2.03    Contract Term. The Contract shall be effective as of December 01,
2016 (the “Effective Date”) and terminate on November 30, 2019 or in accordance with the Contract termination provisions set forth in Article VIII herein, whichever shall occur first (the
“Termination Date”). Unless otherwise approved by the INSTITUTE as evidenced by written communication from the INSTITUTE to the RECIPIENT and appended to the Contract, Grant funds distributed pursuant to the Contract shall be
expended no earlier than the Effective Date or subsequent to the Termination Date. If, as of the Termination Date, the RECIPIENT has not used Grant money awarded by the INSTITUTE for permissible services, expenses, or costs related to the Project
and has not received approval from the INSTITUTE for a no cost extension to the contract term pursuant to Section 3.11 “Carry Forward of Unspent Funds and No Cost Extension” herein, then the RECIPIENT shall not be entitled to retain
such unused Grant funds from the INSTITUTE. Certain obligations as set forth in Section 9.09 of this Contract shall extend beyond the Termination Date. 

Section 2.04    Contract Documentation. The Contract between the INSTITUTE and the RECIPIENT shall
consist of this final, executed Contract, including the following Attachments to the Contract, all of which are hereby incorporated by reference: 
  

	 	(a)	 Attachment A—Project Description, Goals and Timeline 

 

	 	(b)	 Attachment B—Approved Budget, including changes approved by the INSTITUTE subsequent to execution of the
Contract. 

  

	 	(c)	 Attachment C—Assurances and Certifications 

 

	 	(d)	 Attachment D—Intellectual Property and Revenue Sharing 

 

	 	(e)	 Attachment E—Reporting Requirements 

 

	 	(f)	 Attachment F—Approved Amendments to Contract, excluding budget amendments reflected in Attachment B.

 Section 2.05    Entire Agreement. All agreements, covenants, representations,
certifications and understandings between the parties hereto concerning this Contract have been merged into this written Contract. No prior contemporaneous representation, agreement or understanding, express or implied, oral or otherwise, of the
parties or their agents that may have related to the subject matter hereof in any way shall be valid or enforceable unless embodied in this Contract. 

Section 2.06    Amendments and Modifications. Requested amendments and modifications to the Contract must
be submitted in writing to the INSTITUTE for review and approval (such approval shall not be unreasonably withheld.) Amendments and modifications (including alterations, additions, deletions, assignments and extensions) to the terms of this Contract
shall be made solely in writing and shall be executed by both parties. The approved amendment shall be reflected in Attachment A if it is change to the Scope of Work, or as part of Attachment B if it is a budget amendment, or as part of Attachment F
for all other changes. 
 Section 2.07    Relationship of the Parties. The RECIPIENT shall be
responsible for the conduct of the Project that is the subject of this Contract and shall direct the activities and at all times be responsible for the performance of Recipient Personnel, Collaborators, Contractors and other agents. The INSTITUTE
does not assume responsibility for the conduct of the Project or any Institute-Funded Activity that is the subject of this Contract. The INSTITUTE and the RECIPIENT shall perform their respective obligations under this Contract as independent
contractors and not as agents, employees, partners, joint venturers, or representatives of the other party. Neither party is permitted to make representations or commitments that bind the other party. 

  
 3 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 DP160071 

Jason Kim 
  

 Section 2.08    Subcontracting. Any and all subcontracts
entered into by the RECIPIENT in relation to the performance of activities under the Project shall be in writing and shall be subject to the requirements of this Contract. Without in any way limiting the foregoing, the RECIPIENT shall enter into and
maintain a written agreement with each such permitted Contractor with terms and conditions sufficient to ensure the RECIPIENT fully complies with the terms of this Contract, including without limitation the terms set forth in Attachments C, D, and
E. The RECIPIENT agrees that it shall be responsible to the INSTITUTE for the performance of and payment to any Contractor. Any reimbursements made by the RECIPIENT to a Contractor shall be made in accordance with the applicable provisions of TEX.
GOV’T. CODE, Ch. 2251. 
 Section 2.09    Transfer or Assignment by the Recipient. This Contract
is not transferable or otherwise assignable by the RECIPIENT, whether by operation of law or otherwise, without the prior written consent of the INSTITUTE, except as provided in this Section 2.09. Any such attempted transfer or assignment
without the prior written consent of the INSTITUTE (except as provided in this Section 2.09) shall be null, void and of no effect. For purposes of this section, an assignment or transfer of this Contract by the RECIPIENT in connection with a
merger, transfer or sale of all or substantially all of the RECIPIENT’s assets or business related to this Contract or a consolidation, change of control or similar transaction involving the RECIPIENT shall not be deemed to constitute a
transfer or assignment, so long as such action does not impair or otherwise negatively impact the revenue sharing terms in Attachment D. Nothing herein shall be interpreted as superseding the requirement that the Project be undertaken in Texas with
Texas-based employees. 
 If the Principal Investigator leaves the employment of the RECIPIENT or is replaced by the RECIPIENT for any reason during the
course of the Grant with someone who is not already designated a co-Principal Investigator in the Application, the RECIPIENT shall notify the INSTITUTE prior to replacing the Principal Investigator. Written
approval by the INSTITUTE is required for the replacement of the Principal Investigator with someone who is not already a co-Principal Investigator in the Application, which approval shall not be unreasonably
withheld, conditioned or delayed. 
 Section 2.10    Representations and Certifications. The RECIPIENT
represents and certifies to the best of its knowledge and belief to the INSTITUTE as follows: 
  

	 	(a)	 It has legal authority to enter into, execute, and deliver this Contract, and all documents referred to herein,
and it has taken all actions necessary to its execution and delivery of such documents; 

  

	 	(b)	 It will comply with all of the terms, conditions, provisions, covenants, requirements, and certifications in
this Contract, applicable statutory provisions, agency administrative rules, and all other documents incorporated herein by reference; 

  

	 	(c)	 It has made no material false statement or misstatement of fact in connection with this Contract and its
receipt of the Grant, and all of the information it previously submitted to the INSTITUTE or that it is required under this Contract to submit to the INSTITUTE relating to the Grant or the disbursement of any of the Grant is and will be true and
correct at the time such statement is made; 

  

	 	(d)	 It is in compliance in all material respects with provisions of its charter and of the laws of the State of
Texas, and of the laws of the jurisdiction in which it was formed, and (i) there are no actions, suits, or proceedings pending, or threatened, before any judicial body or governmental authority against or affecting its ability to enter into
this Contract, or any document referred to herein, or to perform any of the material acts required of it in such documents and (ii) it is not in default with respect to any order, writ, injunction, decree, or demand of any court or any
governmental authority which would impair its ability to enter into this Contract, or any document referred to herein, or to perform any of the material acts required of it in such documents; 

  
 4 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 DP160071 

Jason Kim 
  

	 	(e)	 Neither the execution and delivery of this Contract or any document referred to herein, nor compliance with any
of the terms, conditions, requirements, or provisions contained in this Contract or any documents referred to herein, is prevented by, is a breach of, or will result in a breach of, any term, condition, or provision of any agreement or document to
which it is now a party or by which it is bound; and 

  

	 	(f)	 It shall furnish such satisfactory evidence regarding the representations and certifications described herein
as may be required and requested by the INSTITUTE from time to time. 

Section 2.11    Reliance upon Representations. By awarding the Grant and executing this Contract, the
INSTITUTE is relying, and will continue to rely throughout the term of this Contract, upon the truthfulness, accuracy, and completeness of the RECIPIENT’s written assurances, certifications and representations. Moreover, the INSTITUTE would not
have entered into this Contract with the RECIPIENT but for such written assurances, certifications and representations. The RECIPIENT acknowledges that the INSTITUTE is relying upon such assurances, certifications and representations and
acknowledges their materiality and significance. 
 Section 2.12    Contingent upon Availability of Grant
Funds. This Contract is contingent upon funding being available for the term of the Contract and the RECIPIENT shall have no right of action against the INSTITUTE in the event that the INSTITUTE is unable to perform its obligations under this
Contract as a result of the suspension, termination, withdrawal, or failure of funding to the INSTITUTE or lack of sufficient funding of the INSTITUTE for this Contract. If funds become unavailable to the INSTITUTE during the term of the Contract,
Section 8.01(c) shall apply. For the sake of clarity, and except as otherwise provided by this Contract, if this Contract is not funded, then both parties are relieved of all of their obligations under this Contract. The INSTITUTE acknowledges
and agrees that the Project is a multiyear project subject to Tex. Health & Safety Code, Ch. 102, Section 102.257. 

Section 2.13    Confidentiality of Documents and Information. In connection with work contemplated for
the Project or pursuant to complying with various provisions of this Contract, the RECIPIENT may disclose its confidential business, financial, technical, scientific information and other information to the INSTITUTE (“Confidential
Information”). To assist the INSTITUTE in identifying such information, the RECIPIENT shall mark or designate the information as “confidential,” provided however that the failure to so designate does not operate as a waiver to
protections provided by applicable law or this Contract. The INSTITUTE shall use no less than reasonable care to protect the confidentiality of the Confidential Information to the fullest extent permissible under the Texas Public Information Act,
Texas Government Code, Chapter 552 (the “TPIA”), and, except as otherwise provided in the TPIA to prevent the disclosure of the Confidential Information to third parties for a period of time equal to three (3) years from
the termination of the contract, unless the INSTITUTE and the RECIPIENT agree in writing to extend such time period, provided that this obligation shall not apply to information that: 

 

	 	(a)	 was in the public domain at the time of disclosure or later became part of the public domain through no act or
omission of the INSTITUTE in breach of this Contract; 

  

	 	(b)	 was lawfully disclosed to the INSTITUTE by a third party having the right to disclose it without an obligation
of confidentiality; 

  

	 	(c)	 was already lawfully known to the INSTITUTE without an obligation of confidentiality at the time of disclosure;

  

	 	(d)	 was independently developed by the INSTITUTE without using or referring to the RECIPIENT’s Confidential
Information; or 

  

	 	(e)	 is required by law or regulation to be disclosed. 

The INSTITUTE shall hold the Confidential Information in confidence, shall not use such Confidential Information except as provided by the terms of this
Contract, and shall not disclose such Confidential Information to third parties without the prior written approval of the RECIPIENT or as otherwise allowed by the terms of the Contract. Subject in all respects to the terms of this Contract and the
TPIA, the INSTITUTE has the right to use and disclose the Confidential Information reasonably in connection with the exercise of its rights under the Contract. 

  
 5 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 DP160071 

Jason Kim 
  

 In the event that the INSTITUTE is requested or required (by oral questions, interrogatories, requests for
information or documents in legal proceedings, subpoena, civil investigative demand or other similar process by a court of competent jurisdiction or by any administrative, legislative, regulatory or self-regulatory authority or entity) to disclose
any Confidential Information, the INSTITUTE shall provide the RECIPIENT with prompt written notice of any such request or requirement so that the RECIPIENT may seek a protective order or other appropriate remedy. If, in the absence of a protective
order or other remedy, the INSTITUTE is nonetheless legally compelled to make any such disclosure of Confidential Information to any person, the INSTITUTE may, without liability hereunder, disclose only that portion of the Confidential Information
that is legally required to be disclosed, provided that the INSTITUTE will use reasonable efforts to assist the RECIPIENT, at the RECIPIENT’s expense, in obtaining an appropriate protective order or other reliable assurance that confidential
treatment will be accorded the Confidential Information. To the extent that such Confidential Information does not become part of the public domain by virtue of such disclosure, it shall remain Confidential Information hereunder. 

Article III 

DISBURSEMENT OF GRANT AWARD PROCEEDS 

Section 3.01    Payment of Grant Award Proceeds. The INSTITUTE will advance Grant award proceeds upon
request by the RECIPIENT, consistent with the amounts and schedule as provided in Attachment B. If the RECIPIENT does not request or the Oversight Committee does not authorize advancement of funds for some or the entire Grant award proceeds,
disbursement of Grant award proceeds for services performed and allowable expenses and costs incurred pursuant to the Scope of Work will be on a reimbursement basis. To the extent that completion of certain milestones is associated with a specific
tranche of funding as reflected in the Scope of Work, those milestones shall be accomplished before funding may be provided for next tranche of funding. The INSTITUTE reserves the right to terminate the Contract should a key milestone not be met.

 Section 3.02     Requests for Reimbursement and Quarterly Financial Status Reports. If the RECIPIENT
does not receive an advance disbursement of Grant proceeds, the RECIPIENT’s requests for reimbursement shall be made on INSTITUTE Form 269a (Financial Status Report). If the RECIPIENT has elected to receive an advance disbursement of Grant
proceeds, RECIPIENT shall submit INSTITUTE Form 269a (Financial Status Report) to document all costs and allowable expenses paid with Grant proceeds. The RECIPIENT shall submit the INSTITUTE Form 269a quarterly to the INSTITUTE within 90 days
following the end of the quarter covered by the bill. A final INSTITUTE Form 269a shall be submitted by RECIPIENT not later than 90 days after the Termination Date. An extension of time for submission deadlines specified herein must be expressly
authorized in writing by the INSTITUTE. 
 Section 3.03     Actual Costs and Allowable Expenses.
Because the Approved budget for the Project(s) as set forth in Attachment B is only an estimate, the parties agree that the RECIPIENT’s billings under this Contract will reflect the actual costs and expenses incurred in performing the
Project(s), regardless of the Approved Budget, up to the total contracted amount specified in Section 2.01 “Award of Monies.” The RECIPIENT shall use Grant proceeds only for allowable expenses consistent with state law and agency
administrative rules. Allowable expenses for the Project(s) shall be only as outlined in the Approved Budget and any modifications to same. 

Section 3.04     Travel Expenses. Reimbursement for travel expenditures shall be in accordance with the
Approved Budget. Prior written approval from the INSTITUTE must be obtained before travel that exceeds the amount included in the Approved Budget commences. Failure to obtain such prior written approval shall result in such excess travel costs
constituting expenses that may not be taken into account for the purposes of calculating expenditure of Grant funds under this Contract. 

  
 6 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 DP160071 

Jason Kim 
  

 Section 3.05     Budget Modifications. The total
Approved Budget and the assignment of costs may be adjusted based on implementation of the Scope of Work, spending patterns, and unexpended funds, but only by an amendment to the Approved Budget. In no event shall an amendment to the Approved Budget
result in payments in excess of the aggregate amount specified in Section 2.01 “Award of Monies” or in approved supplemental funding for the Project, if any. The RECIPIENT may make transfers between or among lines within budget
categories without prior written approval provided that: 
  

	 	(a)	 The total dollar amount of all changes of any single line item within budget categories (individually and in
the aggregate) is less than 10% of the total Approved Budget; 

  

	 	(b)	 The transfer will not increase or decrease the total Approved Budget; 

 

	 	(c)	 The transfer will not materially change the nature, performance level, or Scope of Work of the Project; and

  

	 	(d)	 The RECIPIENT submits a revised copy of the Approved Budget including a narrative justification of the changes
prior to incurring costs in the new category. 

 All other budget changes or transfers require the INSTITUTE’s express prior written
approval. Transfer of funds between categories in the Project’s Approved Budget may be allowed if requests are in writing, fit within the Scope of Work and the total Approved Budget, are beneficial to the achievement of the objectives of the
Project, and appear to be an efficient, effective use of the INSTITUTE’s funds. 

Section 3.06    Withholding Payment. The INSTITUTE may withhold Grant award proceeds from RECIPIENT if
required Financial Status Reports (Form 269a) are not on file for previous quarters or for the final period, if material program requirements are not met and remain uncured after a reasonable time period to cure, if the RECIPIENT is in breach of any
material term of this Contract, or in accordance with provisions of this Contract as well as applicable state or federal laws, regulations or administrative rules, and the breach remains uncured after a reasonable time period to cure. The INSTITUTE
shall have the right to withhold all or part of any future payments to the RECIPIENT to offset any prior advance payments made to the RECIPIENT for ineligible expenditures that have not been refunded to the INSTITUTE by the RECIPIENT. 

Section 3.07    Grant Funds as Supplement to Budget. The RECIPIENT shall use the Grant proceeds awarded
pursuant to this Contract to supplement its overall budget. These funds will in no event supplant existing funds currently available to the RECIPIENT that have been previously budgeted and set aside for the Project. The RECIPIENT will not bill the
INSTITUTE for any costs under this Contract that also have been billed or should have been billed to any other funding source. 

Section 3.08    Buy Texas. The RECIPIENT shall apply good faith efforts to purchase goods and services
from suppliers in Texas to the extent reasonably possible, to achieve a goal of more than 50 percent of such purchases from suppliers in Texas. 

Section 3.09    Historically Underutilized Businesses. The RECIPIENT shall use reasonable efforts to
purchase materials, supplies or services from a Historically Underutilized Business (HUB). The Texas Procurement and Support Services website will assist in finding HUB vendors (http://www.window.state.tx.us/procurement.) The RECIPIENT shall
complete a HUB report with each annual report submitted to the INSTITUTE in accordance with Attachment E. 

Section 3.10    Limitation on Use of Grant Award Proceeds to Pay Indirect Costs. The RECIPIENT shall not
spend more than five percent of the Grant award proceeds for Indirect Costs. 
 Section 3.11    Carry
Forward of Unspent Funds and No Cost Extension. RECIPIENT may request to carry forward unspent funds into the budget for the next year. Carryover of unspent funds must be specifically approved by the INSTITUTE. The INSTITUTE may approve a no
cost extension for the Contract for a period not to exceed six (6) months after the Termination Date if additional time beyond the Termination date is required to ensure adequate completion of the approved project. The Contract must be in good
fiscal and programmatic standing. All terms and conditions of the Contract shall continue during any extension period and if such extension is approved, notwithstanding Section 2.03, all references to the “Termination Date” shall be
deemed to mean the date of expiration of such extension period. 

  
 7 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 DP160071 

Jason Kim 
  

 Article IV 

AUDITS AND INSPECTIONS 

Section 4.01    Record Keeping. The RECIPIENT, each Collaborator whose costs are funded in all or in part
by the Grant shall maintain or cause to be maintained books, records, documents and other evidence (electronic or otherwise) pertaining in any way to its performance under and compliance with the terms and conditions of this Contract
(“Records”). The RECIPIENT, each Collaborator and each Contractor shall use, or shall cause the entity which is maintaining such Records to use generally accepted accounting principles in the maintenance of such Records, and
shall retain or require to be retained all of such Records for a period of three (3) years from the Termination Date of the Contract. 

Section 4.02    Audits. Upon request and with reasonable notice, the RECIPIENT, each Collaborator and
each Contractor whose costs are charged to the Project shall allow, or shall cause the entity which is maintaining such items to allow, the INSTITUTE, or auditors working on behalf of the INSTITUTE, including the State Auditor and/or the Comptroller
of Public Accounts for the State of Texas, to review, inspect, audit, copy or abstract all of its Records during regular working hours. Acceptance of funds directly under the Contract or indirectly through a subcontract under the Contract
constitutes acceptance of the authority of the INSTITUTE, or auditors working on behalf of the INSTITUTE, including the State Auditor and/or the Comptroller of Public Accounts, to conduct an audit or investigation in connection with those funds for
a period of three (3) years from the Termination Date of the Contract. 
 Notwithstanding the foregoing, any RECIPIENT expending $500,000 or more in
federal or state awards during its fiscal year shall obtain either an annual single audit or a program specific audit. A RECIPIENT expending funds from only one state program may elect to obtain a program specific audit in accordance with Office of
Management and Budget (OMB) Circular A-133 or with the State of Texas Uniform Grant Management Standards (UGMS). A single audit is required if funds from more than one federal or state program are spent by the
RECIPIENT. The audited time period is the RECIPIENT’s fiscal year, not the INSTITUTE funding period. 

Section 4.03    Inspections. In addition to the audit rights specified in Section 4.02
“Audits”, the INSTITUTE shall have the right to conduct periodic onsite inspections within normal working hours and on a day and a time mutually agreed to by the parties, to evaluate the Institute-Funded Activity. The RECIPIENT shall fully
participate and cooperate in any such evaluation efforts. 

Section 4.04    On-going Obligation to Submit Requested
Information. The RECIPIENT shall, submit other information related to the Grant to the INSTITUTE as may be reasonably requested from time-to-time by the INSTITUTE,
by the Legislature or by any other funding or regulatory bodies covering the RECIPIENT’s activities under this Contract. 

Section 4.05    Duty to Resolve Deficiencies. If an audit and/or inspection under this Article IV finds
there are deficiencies that should be remedied, then the RECIPIENT shall resolve and/or cure such deficiencies within a reasonable time frame specified by the INSTITUTE. Failure to do so shall constitute an Event of Default pursuant to
Section 8.03 “Event of Default.” Upon the RECIPIENT’S request, the parties agree to negotiate in good faith, specific extensions so that the RECIPIENT can cure such deficiencies. 

Section 4.06    Repayment of Grant Proceeds for Improper Use. In no event shall RECIPIENT retain Grant
funds that have not been used by the RECIPIENT for purposes for which the Grant was intended or in violation of the terms of this Contract. The RECIPIENT shall repay any portion of Grant proceeds used by the RECIPIENT for purposes for which the
Grant was not intended, as determined by the final results of an audit conducted pursuant to the provisions of this Contract. Unless otherwise expressly provided for in writing and appended to this Contract, the repayment shall be made to the
INSTITUTE no later than forty-five (45) days upon a written request by the INSTITUTE specifying the amount to be repaid and detailing the basis upon which such request is being made and the amount shall include interest calculated at an amount
not to exceed five percent (5%) annually. The RECIPIENT may request that the INSTITUTE waive the interest, subject in all cases to the INSTITUTE’S sole discretion. 

  
 8 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 DP160071 

Jason Kim 
  

 Section 4.07    Repayment of Grant Proceeds for Relocation
Outside of Texas. Unless waived by a vote of the Oversight Committee, the RECIPIENT shall repay the INSTITUTE all Grant proceeds disbursed to RECIPIENT in the event that RECIPIENT relocates its principal place of business outside of the State
during the Contract term or within 3 years after the final payment of the Grant funds is made by the INSTITUTE. 
 Article V 

ASSURANCES AND CERTIFICATIONS 
 Adoption
of Attachment C. The INSTITUTE and the RECIPIENT hereby adopt the terms of Attachment C in their entirety, incorporate them as if fully set forth herein, and agree to perform and be bound by all such terms. 

Article VI 
 INTELLECTUAL
PROPERTY AND REVENUE SHARING 
 Adoption of Attachment D. The INSTITUTE and the RECIPIENT hereby adopt the terms of Attachment D in their
entirety, incorporate them as if fully set forth herein, and agree to perform and be bound by all such terms. 
 Article VII 

REPORTING 
 Adoption of Attachment
E. The INSTITUTE and the RECIPIENT hereby adopt the terms of Attachment E in their entirety, incorporate them as if fully set forth herein, and agree to perform and be bound by all such terms. 

Article VIII 
 EARLY
TERMINATION AND EVENT OF DEFAULT 
 Section 8.01    Early Termination of Contract. This Contract
may be terminated prior to the Termination Date specified in Section 2.03 “Contract Term” by: 
  

	 	(a)	 Mutual written consent of all parties to this Contract; or 

 

	 	(b)	 The INSTITUTE for an Event of Default (defined in Section 8.03) by the RECIPIENT; or

  

	 	(c)	 The INSTITUTE if allocated funds should become legally unavailable during the Contract period and the INSTITUTE
is unable to obtain additional funds for such purposes; or 

  

	 	(d)	 The RECIPIENT for convenience. 

Section 8.02    Repayment of Grant Proceeds upon Early Termination. The INSTITUTE may require the
RECIPIENT to repay some or all of the disbursed Grant proceeds in the event of early termination under 8.01 (d) above or under Section 8.01(b) above, to the extent such Event of Default resulted from Grant funds being expended in violation of
this Contract. To the extent that the INSTITUTE exercises this option, the INSTITUTE shall provide written notice to the RECIPIENT stating the amount to be repaid, applicable interest calculated not to exceed five percent (5%) annually, and the
schedule for such repayment. The RECIPIENT may request that the INSTITUTE waive the interest, subject in all cases to the INSTITUTE’S sole discretion. In no event shall the RECIPIENT retain Grant funds that have not been used by the RECIPIENT
for purposes for which the Grant was intended. 

  
 9 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 DP160071 

Jason Kim 
  

 Section 8.03    Event of Default. The following events
shall, unless expressly waived in writing by the INSTITUTE or fully cured by the RECIPIENT pursuant to the provisions herein, constitute an event of default (each, an “Event of Default”): 

 

	 	(a)	 The RECIPIENT’s failure, in any material respect, to conduct the Project in accordance with the approved
Scope of Work and to demonstrate progress towards achieving the milestones set forth in Section 2.02; 

  

	 	(b)	 The RECIPIENT’s failure to conduct the Project within the State of Texas to the extent required under this
Contract unless as otherwise specified in the application, Scope of Work or Approved Budget; 

  

	 	(c)	 The RECIPIENT’s failure to fully comply, in any material respect, with any provision, term, condition,
covenant, representation, certification, or warranty contained in this Contract or any other document incorporated herein by reference; 

  

	 	(d)	 The RECIPIENT’s failure to comply with any applicable federal or state law, administrative rule,
regulation or policy with regard to the conduct of the Project; 

  

	 	(e)	 The RECIPIENT’s material misrepresentation or false covenant, representation, certification, or warranty
made by RECIPIENT herein, in the Grant application, or in any other document furnished by RECIPIENT pursuant to this Contract that was misleading at the time that it was made; or 

 

	 	(f)	 The RECIPIENT ceases its business operations, has a receiver appointed for all or substantially all of its
assets, makes a general assignment for the benefit of creditors, is declared insolvent by a court of competent jurisdiction or becomes the subject, as a debtor, of a proceeding under the federal bankruptcy code, which such proceedings are not
dismissed within ninety (90) days after filing. 

 Section 8.04    Notice
Required. If the RECIPIENT intends to terminate pursuant to Section 8.01(d) “Early Termination of Contract”, it shall provide written notice to the INSTITUTE pursuant to the notice provisions of Section 9.21
“Notices” no later than thirty (30) days prior to the intended date of termination. 
 If the INSTITUTE intends to terminate for an Event of
Default under Section 8.01(b) by the RECIPIENT, as described in Section 8.03 “Event of Default”, the INSTITUTE shall provide written notice to the RECIPIENT pursuant to Section 9.21 “Notices” and shall include a
reasonable description of the Event of Default and, if applicable, the steps necessary to cure such Event of Default. Upon receiving notice from the INSTITUTE, the RECIPIENT shall have thirty (30) days beginning on the day following the receipt
of notice to cure the Event of Default. Upon request, the INSTITUTE may provide an extension of time to cure the Event of Default(s) beyond the thirty (30) day period specified herein so long as the RECIPIENT is using reasonable efforts to cure
and is making reasonable progress in curing such Event(s) of Default. The extension shall be in writing and appended to the Contract. If the RECIPIENT is unable or fails to timely cure an Event of Default, unless expressly waived in writing by the
INSTITUTE, this Contract shall immediately terminate as of the close of business on the final day of the allotted cure period without any further notice or action by the INSTITUTE required. In addition, and notwithstanding the foregoing, the
INSTITUTE and the RECIPIENT agree that certain events that cannot be cured shall, unless expressly waived in writing by the INSTITUTE, constitute a final Event of Default under this Contract and this Contract shall terminate immediately upon the
INSTITUTE giving the RECIPIENT written “Notice of Event of Default and FINAL TERMINATION.” 
 In the event that the INSTITUTE terminates the
Contract under Section 8.01(c) above because allocated funds become legally unavailable during the Contract period, the INSTITUTE shall immediately provide written notification to the RECIPIENT of such fact pursuant to Section 9.21
“Notices.” The Contract is terminated upon the RECIPIENT’s receipt of that notification, subject to Section 9.09 “Survival of Terms.” 

Section 8.05    Duty to Report Event of Default. The RECIPIENT shall notify the INSTITUTE in writing
pursuant to Section 9.21 “Notices”, promptly and in no event more than (30) days after it obtains knowledge of the occurrence of any Event of Default. The RECIPIENT shall include a statement setting forth reasonable details of
each Event of Default and the action which the RECIPIENT proposes to take with respect thereto. 

  
 10 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 DP160071 

Jason Kim 
  

 Section 8.06    Obligations/Liabilities Affected by Early
Termination. The RECIPIENT shall not incur new obligations that otherwise would have been paid for using Grant funds after the receipt of notice as provided by Section 8.04 “Notice Required”, unless expressly permitted by the
INSTITUTE in writing, and shall cancel as many outstanding obligations as possible. The INSTITUTE shall not owe any fee, penalty or other amount for exercising its right to terminate the Contract in accordance with Section 8.01. In no event
shall the INSTITUTE be liable for any services performed, or costs or expenses incurred, after the Termination Date of the Contract. Early termination by either party shall not nullify obligations already incurred, including the RECIPIENT’s
revenue sharing obligations as set forth in Attachment D, or the performance or failure to perform obligations prior to the Termination Date. 

Section 8.07    Interim Remedies. Upon receipt by the RECIPIENT of a notice of Event of Default, and at
any time thereafter until such Event of Default is cured to the satisfaction of the INSTITUTE or this Contract is terminated, the INSTITUTE may enforce any or all of the following remedies (such rights and remedies being in addition to and not in
lieu of any rights or remedies set forth herein): 
  

	 	(a)	 The INSTITUTE may refrain from disbursing any amount of the Grant funds not previously disbursed; provided,
however, the INSTITUTE may make such a disbursement after the occurrence of an Event of Default without thereby waiving its rights and remedies hereunder; 

  

	 	(b)	 The INSTITUTE may enforce any additional remedies it has in law or equity. 

The rights and remedies herein specified are cumulative and not exclusive of any rights or remedies that the INSTITUTE would otherwise possess. 

Article IX 

MISCELLANEOUS 

Section 9.01    Uniform Grant Management Standards. Unless otherwise provided herein, the RECIPIENT
agrees that the Uniform Grant Management Standards (UGMS), developed by the Governor’s Budget and Planning Office as directed under the Uniform Grant Management Act of 1981, TEX. GOVT. CODE, Ch. 783, apply as additional terms and conditions of
this Contract and that the standards are adopted by reference in their entirety. If there is a conflict between the provisions of this Contract and UGMS, the provisions of this Contract will prevail unless expressly stated otherwise. 

Section 9.02    Management and Disposition of Equipment. During the term of this Contract, the RECIPIENT
may use Grant funds to purchase Equipment to be used for the authorized purpose of the Project, subject to the conditions set forth below. Unless otherwise provided herein, title to Equipment shall vest in the RECIPIENT upon termination of the
Contract. 
  

	 	(a)	 The INSTITUTE must authorize the acquisition in advance and in writing but an acquisition is deemed authorized
if included in the Approved Budget for the Project; 

  

	 	(b)	 Equipment purchased with Grant funds must stay within the State of Texas; 

 

	 	(c)	 Equipment purchased with Grant funds must be materially deployed to the uses and purposes related to the
Project; 

  

	 	(d)	 In the event the RECIPIENT is indemnified, reimbursed or otherwise compensated for any loss of, destruction of,
or damage to the Equipment purchased using Grant funds, it shall use the proceeds to repair or replace said Equipment; 

  

	 	(e)	 Equipment may be exchanged (trade-in) or sold without the prior written
approval of the INSTITUTE if the proceeds thereof shall be applied to the acquisition cost of replacement Equipment; 

  
 11 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 DP160071 

Jason Kim 
  

	 	(f)	 The RECIPIENT may use its own property management standards and procedures provided that it observes the terms
of UGMS, A-102, in all material respects; 

  

	 	(g)	 The title or ownership of the Equipment shall not be encumbered for purposes other than the Project nor or
transferred other than to a permitted assignee of this Contract, without the prior written approval of the INSTITUTE; 

  

	 	(h)	 If the original or replacement Equipment is no longer needed for the originally authorized purpose or for other
activities supported by the INSTITUTE, the RECIPIENT shall request disposition instructions from the INSTITUTE and, upon receipt, shall fully comply therewith; and 

 

	 	(i)	 If this Contract is terminated early pursuant to Section 8.01(b), (d), (e), or (f) above, the
INSTITUTE shall determine the final disposition of Equipment purchased with Grant award money. 

Section 9.03    Supplies and Other Expendable Property. The RECIPIENT shall classify as materials,
supplies and other expendable property the allowable unit acquisition cost of such property under $5,000 necessary to carry out the Project. Title to supplies and other expendable property shall vest in the RECIPIENT upon acquisition. 

Section 9.04    Acknowledgement of Grant Funding and Publicity. The parties agree to the following terms
and conditions regarding acknowledging Grant funding and publicity: 
  

	 	(a)	 The parties agree to fully cooperate and coordinate with each other in connection with all press releases and
publications regarding the award of the Grant, the execution of the Contract and the Institute-Funded Activities. 

  

	 	(b)	 The RECIPIENT shall notify the INSTITUTE’s Information Specialist or similar personnel at least three
business days prior to any press releases, advertising, publicity, use of CPRIT logo, or other promotional activities that pertain to the Project or any Institute-Funded Activity. In the event that the INSTITUTE wishes to participate in a joint
press release, the RECIPIENT shall coordinate and cooperate with the INSTITUTE’s Information Specialist or similar personnel to develop a mutually agreeable joint press release. 

 

	 	(c)	 Consistent with the goal of encouraging development of scientific breakthroughs and dissemination of knowledge,
publication or presentation of scholarly materials is expected and encouraged. The RECIPIENT may publish in scholarly journals or other peer-reviewed journals (including graduate theses and dissertations) and may make presentations at scientific
meetings without prior notice to or consent of the INSTITUTE, except as may otherwise be set forth in this Contract. The RECIPIENT shall promptly notify the INSTITUTE when any scholarly presentations or publications have been accepted for public
disclosure and shall provide the INSTITUTE with final copies of all such accepted presentations and publications. The RECIPIENT shall acknowledge receipt of the INSTITUTE funding in all publications, presentations, press releases and other materials
regarding the work associated with the Institute-Funded Activities. The RECIPIENT shall promptly submit an electronic version of all published manuscripts to PubMed Central in accordance with Section 9.05 “Public Access to Research
Results.” 

  

	 	(d)	 When grant funds are used to prepare print or visual materials for educational or promotional purposes for the
general public (e.g., patients), and excluding presentations and publications discussed above in subsection (c), the RECIPIENT shall provide a copy of such materials to the INSTITUTE at least ten (10) days prior to printing. The RECIPIENT shall
also acknowledge receipt of the INSTITUTE funding on all such materials including, but not limited to, brochures, pamphlets, booklets, training fliers, project websites, videos and DVDs, manuals and reports, as well as on the labels and cases for
audiovisual or videotape/DVD presentations. 

  
 12 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 DP160071 

Jason Kim 
  

 Section 9.05    Public Access to Results of Institute-Funded
Activities. The RECIPIENT shall submit an electronic version of its final peer-reviewed journal manuscripts that arise from Grant funds to the digital archive National Library of Medicine’s PubMed Central upon acceptance for publication.
These papers must be accessible to the public on PubMed no later than 12 months after publication. This policy is subject to the terms of Attachment D and does not supplant applicable copyright law. For clarity, this policy is not intended to
require the RECIPIENT to make a disclosure at a time or in any manner that would cause the RECIPIENT to abandon, waive or disclaim any intellectual property rights that it is obligated to protect pursuant to the terms of Attachment D. 

Section 9.06    Work to be Conducted in State. The RECIPIENT agrees that it will use reasonable efforts
to direct that any new or expanded preclinical testing, clinical trials, commercialization or manufacturing that is part of or relating to any Institute-Funded Activities take place in the State of Texas, including the establishment of facilities to
meet this purpose. If the RECIPIENT decides not to conduct such work in the State of Texas, the RECIPIENT shall provide a prior written explanation to the INSTITUTE detailing the RECIPIENT’s reasons for conducting the work outside of the State
of Texas and the RECIPIENT’s efforts made to conduct the work in the State of Texas. 

Section 9.07    Duty to Notify. During the term of this Contract and for a period of five (5) years
thereafter, the RECIPIENT is under a continuing obligation to notify the INSTITUTE’s Chief Executive Officer at the same time it is required to notify any Federal or State entity of any unexpected adverse event or condition that materially
impacts the performance or general public perception of the conduct or results of the Project and Institute-Funded Activities, including any impact to the Scope of Work included in the Contract and events or results that have a serious adverse
impact on human health, safety or welfare. By way of example only, if clinical testing of the results of Institute-Funded Activities reveal an unexpected risk of developing serious health conditions or death, then the RECIPIENT shall, at the same
time it notifies any Federal or State entity, promptly so notify the INSTITUTE’s Chief Executive Officer even if such results are not available until after the term of this Contract. Notice required under this section shall be made as promptly
as reasonably possible and shall follow the procedures set forth in Section 9.21 “Notices.” 

Section 9.08    Severability. If any provision of this Contract is construed to be invalid, illegal or
unenforceable in any respect, such invalidity, illegality or enforceability shall not affect any other provisions hereof. The invalid, illegal or unenforceable provision shall be deemed stricken and deleted to the same extent and effect as if never
incorporated herein. All other provisions shall continue as provided in this Contract. 

Section 9.09    Survival of Terms. Termination or expiration of this Contract for any reason will not
release either party from any liabilities or obligations set forth in this Contract that: (1) the Parties have expressly agreed shall survive any such termination or expiration; or (2) remain to be performed or by their nature would be
intended to be applicable following any such termination or expiration. Such surviving terms include, but are not limited to, Sections 2.13, 4.01, 4.02, 4.05, 4.06, 8.02, 8.06, 9.04, 9.05, 9.06, 9.07, 9.09, 9.14, 9.15, 9.16, 9.17, 9.18, and
Attachment D. 
 Section 9.10    Binding Effect and Assignment or Modification. This Contract and all
terms, provisions and obligations set forth herein shall be binding upon and shall inure to the benefit of the parties and their successors and permitted assigns, including all other state agencies and any other agencies, departments, divisions,
governmental entities, public corporations or other entities which shall be successors to either of the parties or which shall succeed to or become obligated to perform or become bound by any of the covenants, agreements or obligations hereunder of
either of the parties hereto. Upon a permitted assignment of this Contract by RECIPIENT, all references to “the RECIPIENT” herein shall be deemed to refer to such permitted assignee. 

Section 9.11    No Waiver of Contract Terms. Neither the failure by the RECIPIENT or the INSTITUTE, in
any one or more instances, to insist upon the complete and total observance or performance of any term or provision hereof, nor the failure of the RECIPIENT or the INSTITUTE to exercise any right, privilege or remedy conferred hereunder or afforded
by law, shall be construed as waiving any breach of such term or provision or the right to exercise such right, privilege or remedy thereafter. In addition, no delay on the part of either the RECIPIENT or the INSTITUTE, in exercising any right or
remedy hereunder shall operate as a waiver thereof, nor shall any single or partial exercise of any right or remedy preclude other or further exercise thereof or the exercise of any other right or remedy. 

  
 13 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 DP160071 

Jason Kim 
  

 Section 9.12    No Waiver of Sovereign Immunity. No
provision of this Contract is in any way intended to constitute a waiver by the INSTITUTE, the RECIPIENT (if applicable), or the State of Texas of any immunities from suit or from liability that the INSTITUTE, the RECIPIENT, or the State of Texas
may have by operation of law. 
 Section 9.13    Force Majeure. Neither the INSTITUTE nor the RECIPIENT
will be liable for any failure or delay in performing its obligations under the Contract if such failure or delay is due to any cause beyond the reasonable control of such party, including, but not limited to, unusually severe weather, strikes,
natural disasters, fire, civil disturbance, epidemic, war, court order or acts of God. The existence of such causes of delay or failure will extend the period of performance in the exercise of reasonable diligence until after the causes of delay or
failure have been removed. Each party must inform the other in accordance with Section 9.21 “Notices” within five (5) business days, or as soon as it is practical, of the existence of a force majeure event or otherwise waive this
right as a defense. 
 Section 9.14    Disclaimer of Damages. IN NO EVENT WILL EITHER PARTY BE LIABLE TO THE OTHER PARTY FOR ANY
INDIRECT, SPECIAL, PUNITIVE, EXEMPLARY, INCIDENTAL OR CONSEQUENTIAL DAMAGES. THIS LIMITATION WILL APPLY REGARDLESS OF WHETHER OR NOT THE OTHER PARTY HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES. 

Section 9.15    Indemnification and Hold Harmless. Except as provided herein, the RECIPIENT agrees to
fully indemnify and hold the INSTITUTE and the State of Texas harmless from and against any and all claims, demands, costs, expenses, liabilities, causes of action and damages of every kind and character (including reasonable attorneys fees) which
may be asserted by any third party in any way related or incident to, arising out of, or in connection with (1) the RECIPIENT’s negligent, intentional or wrongful performance or failure to perform under this Contract, (2) the
RECIPIENT’s receipt or use of Grant funds, or (3) any negligent, intentional or wrongful act or omission committed by the RECIPIENT as part of an Institute-Funded Activity or during the Project. In addition, the RECIPIENT agrees to fully
indemnify and hold the INSTITUTE and the State of Texas harmless from and against any and all costs and expenses of every kind and character (including reasonable attorneys fees, costs of court and expert fees) that are incurred by the INSTITUTE or
the State of Texas arising out of or related to a third party claim of the type specified in the preceding sentence. Notwithstanding the preceding, such indemnification shall not apply in the event of the sole or gross negligence of the INSTITUTE.
If the RECIPIENT is a State of Texas agency or institution of higher education, then this Section 9.15 is subject to the extent authorized by the Texas Constitution and the laws of the State of Texas. 

The RECIPIENT acknowledges and agrees that this indemnification shall apply to, but is not limited to, employment matters, taxes, personal injury, and
negligence. 
 It is understood and agreed that it is not the intent of the parties to expand or increase the liability of the State of Texas under this
Article. This provision is intended to prevent the RECIPIENT, the INSTITUTE and the State of Texas from attempting or appearing to assume liability it does not have the statutory or legal power to assume. 

Section 9.16    Alternative Dispute Resolution. If applicable, the dispute resolution process provided
for in TEX. GOVT. CODE, Ch. 2260 shall be used, as further described herein, to resolve any claim for breach of contract made against the INSTITUTE (excluding any uncured Event of Default). The submission, processing and resolution of a party’s
claim are governed by the published rules adopted by the Attorney General pursuant to TEX. GOVT. CODE, Ch. 2260, as currently effective, hereafter enacted or subsequently amended. 

Section 9.17    Applicable Law and Venue. This Contract shall be construed and all disputes shall be
considered in accordance with the laws of the State of Texas, without regard to its principles governing the conflict of laws. Provided that the RECIPIENT first complies with procedures set forth in Section 9.16 “Alternative Dispute
Resolution,” exclusive venue and jurisdiction for the resolution of claims arising from or related to this Contract shall be in the federal and state courts in Travis County, Texas. 

Section 9.18    Attorneys’ Fees. In the event of any litigation, appeal or other legal action to
enforce any provision of the Contract, the RECIPIENT shall pay all expenses of such action, including attorneys’ fees and costs, if the INSTITUTE is the prevailing party. If the RECIPIENT is a State of Texas agency or institution of higher
education, then this Section 9.18 is subject to the extent authorized by the Texas Constitution and the laws of the State of Texas. 

  
 14 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 DP160071 

Jason Kim 
  

 Section 9.19    Counterparts. This Contract may be
executed in any number of counterparts, each of which when so executed and delivered shall be an original, but such counterparts shall together constitute one and the same instrument. 

Section 9.20    Construction of Terms. The headings used in this Contract are inserted only as a matter
of convenience and for reference and shall not affect the construction or interpretation of this Contract. Where context so indicates, a word in the singular form shall include the plural, a word in the masculine form the feminine, and vice-versa.
The word “including” and similar constructions (such as “includes”, “included”, “for example”, “such as”, and “e.g.”) shall mean “including, without limitation” throughout this
Contract. The words “and” and “or” are not intended to convey exclusivity or nonexclusivity except where expressly indicated or where the context so indicates in order to give effect to the intent of the parties. 

Section 9.21    Notices. All notices, requests, demands and other communications will be in writing and
will be deemed given on the date received as demonstrated by (i) a courier’s receipt or registered or certified mail return receipt signed by the party to whom such notice was sent, provided that such notice was sent to the Authorized
Signing Official (ASO) at the address provided in the CPRIT Grants Management System, (ii) a fax confirmation page showing that such fax was successfully transmitted to the fax number provided in the CPRIT Grants Management System, or
(iii) via correspondence in the CPRIT Grants Management System. 

  
 15 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 

 
 DP160071, Contract Attachment A 

Abstract and Significance 
 Multiple myeloma accounts for
10% of all hematological malignancies in the United States. An estimated 26,850 people were diagnosed with the disease in the United States in 2015 with an estimated 11,200 deaths resulting from the disease (SEER Cancer Statistics, 2015). The
five-year survival rate for myeloma is only 45%. 
 Historically, there have been three major classes of therapeutics used to treat multiple myeloma:
steroids, proteasome inhibitors, and the thalidomide-derived immunomodulatory drugs (IMiDs). In 2015, daratumumab, an antibody to CD38, and elotuzumab, an antibody to CS1, became the first biologics approved for multiple myeloma. Daratumumab in
particular has shown robust single-agent activity (29% response rate) in relapsed/refractory patients indicating that CD38 plays an important role in myeloma disease progression. 

Because of the generally poor outcome in myeloma patients, there is a high need for new therapeutics to treat the disease. Molecular Templates has developed a
novel scaffold of biologics against cancer by fusing the single chain variable fragment of an antibody (scFv) to a proprietarily modified form of the Shiga-like toxin A subunit (SLTA), an enzymatic inactivator of ribosome activity. These compounds
combine the specificity of an antibody with a novel and potent direct mechanism of cell-kill. Molecular Templates’ first compound, MT-3724 targets CD20 and is in a first-in-human dose-escalation study at MD Anderson and Memorial Sloan Kettering in heavily pre-treated patients with
non-Hodgkins lymphoma (NHL). To date, there have been twelve patients treated with no dose-limiting toxicities seen. Of the eleven patients evaluable for efficacy, there has been one complete metabolic
response (patient to undergo allogeneic transplant), one partial response, one mixed response, three stable diseases (all with tumor regression), and five patients with progressive disease. This efficacy is especially impressive since MT-3724 has not yet reached linear pharmacokinetics in its dose escalation. 
 Molecular Templates has designed MT-4019ND for the treatment of multiple myeloma. MT-4019ND has a high-affinity scFv that specifically targets CD38 fused to a proprietary
de-immunized form of SLTA. MT-4019ND has shown extremely potent in vitro and in vivo activity against tumor cells expressing CD38.
MT-4019ND has shown potent synergistic activity in combination with pomalidomide, the standard of care for refractory myeloma patients. MT-4019ND mirrors MT-3724 in terms of scaffold construction with similar absorption, distribution, metabolism and excretion (ADME) and pharmacokinetics (PK) characteristics. 

CD38 was chosen as a target because of the clinical activity of daratumumab. Daratumumab works primarily by directing complement dependent cytotoxicity (CDC)
and antibody-dependent cell-mediated cytotoxicity (ADCC) to CD38+ myeloma cells. Although immune recruitment can be a potent mechanism of cell-kill, roughly 70% of CD38+ refractory patients fail to respond to daratumumab monotherapy. 

There is strong precedence in oncology for developing different mechanisms of action against the same validated target. There is an approved antibody, small
molecule, and antibody-drug conjugate targeting HER2 in breast cancer, for example as well as multiple small molecules and antibodies to EGFR. In multiple myeloma, three different IMiDs (lenalidomide, pomalidomide, and thalidomide) are used
sequentially in treatment. MT-4019ND was engineered to provide a different mechanism of destruction targeting CD38+ myelomas. In in vitro and in vivo studies, MT-4019ND
shows excellent specificity, potency and safety as well as synergistic activity in combination with an IMiD. MT-3724 is administered as an infusion and has predictable PK and ADME characteristics. MT-4019ND shares a scaffold with MT-3724 which has shown excellent safety and notable efficacy in its
first-in-human study. 

  
 16 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 This application outlines a strategy to move MT-4019ND into clinical
studies and rapidly characterize its activity in myeloma patients with no other treatment options. The development plan outlined in this application follows that of daratumumab and has the potential to show early signs of safety and efficacy and to
form the basis of an accelerated FDA approval. Molecular Templates has successfully demonstrated that it can efficiently move pre-clinical leads into first-in-human studies. The early clinical data seen the company’s lead compound MT-3724 strongly suggest the scaffold used to construct MT-4019ND is safe and effective. 

  
 17 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 Layperson’s Summary 

In 2015, there were approximately 27,000 new cases of multiple myeloma diagnosed in the US making it the second most prevalent blood cancer. The five-year
survival rate for multiple myeloma is 45% and the median survival is approximately 4 years. 
 CD38 is a protein expressed on the surface of myeloma cells.
Recently, daratumumab, an antibody that specifically targets CD38, was approved for the treatment of patients with multiple myeloma. Daratumumab works primarily by binding myeloma cells and recruiting an immune response to them. Most patients’
immune system will ultimately stop responding to daratumumab allowing the disease to progress. 
 Molecular Templates, a venture-backed biopharmaceutical
company in Georgetown, TX, has developed a novel multiple myeloma drug that targets CD38 but works in a different way from daratumumab. MT-4019ND is a fusion of an antibody fragment that binds CD38 with a
highly toxic bacterial protein. MT-4019ND binds CD38 on the surface of myeloma cells but instead of recruiting an immune response, it directly kills the myeloma cell through its toxin component. MT-4019ND has shown a potent ability to kill myeloma cell lines in the laboratory and in animal models of myeloma. Molecular Templates has a similar compound in the clinic for lymphoma that appears safe and
effective in patients. 
 Molecular Templates seeks $15.3M in CPRIT financing to move MT-4019ND through clinical
studies in patients with refractory multiple myeloma. 

  
 18 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 Timelines: project_timeline.pdf  

 

			
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	 Objective 1:
 ADDED
	  	[***]
		
	 Objective 2:
 ADDED
	  	[***]

  
 19 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 TIMELINE 

[***] 

  
 20 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 

 
 Grant ID: DP160071 

Principal Investigator/Program Director: Jason Kim 

ATTACHMENT B—Detailed Budget Form 
  

									
	 Budget
	  	Budget Year 1	  	Budget Year 2	  	Budget Year 3	  	Total Budget
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	$15,200,000.00
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	$15,200,000.00

			
	 * Note:
 [***]
	  	
	 [***]
	  	 [***]

	 [***]
	  	 [***]

	 [***]
	  	 [***]

	 [***]
	  	 [***]

	 [***]
	  	
	 [***]
	  	 [***]

	 [***]
	  	 [***]

	 [***]
	  	 [***]

	 [***]
	  	 [***]

  
 21 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 

 
 ATTACHMENT C 

ASSURANCES AND CERTIFICATIONS 
 This
Attachment C is hereby incorporated into and made a part of that certain CANCER RESEARCH GRANT CONTRACT (“Contract”) by and between the Cancer Prevention and Research Institute of Texas (“CPRIT”
or the “INSTITUTE”) and the RECIPIENT. A capitalized term used in this Attachment shall have the meaning given to term in the Contract or in the Attachments to the Contract, unless otherwise defined herein. In the event of a
conflict between the provisions of this Attachment and the provisions of the Contract, this Attachment shall control. 
 By signing this Contract,
RECIPIENT certifies compliance with the following assurances and certifications required by the INSTITUTE (listed below). RECIPIENT further acknowledges that its obligations pursuant to the following assurances and certifications are ongoing.

 Section C1.01    Demonstration of Matching Funds. Pursuant to TEX. HEALTH & SAFETY CODE § 102.255(d)
and T.A.C. 25 § 703.11, RECIPIENT has an amount of funds equal to one-half of the amount of the Grant to be disbursed each fiscal year of the Contract term dedicated to the research that is the subject of
the Grant as demonstrated by the form incorporated herein to Attachment C. The RECIPIENT shall update the matching funds certification and verficiation annually for each fiscal year that Grant funds are disbursed. 

Section C1.02    Payment of Taxes. RECIPIENT’s payment of franchise taxes is current or, if the RECIPIENT is exempt
from payment of franchise taxes, that it is not subject to the State of Texas franchise tax. If franchise tax payments become delinquent during the Contract term, payments under this Contract will be withheld until the RECIPIENT’s delinquent
franchise tax is paid in full. The RECIPIENT also acknowledges that it is not otherwise exempt from state sales or occupancy tax as a result of this Contract. 

Section C1.03    Compliance with Confidentiality Guidelines Relating to Personal and Medical 

Information. RECIPIENT complies with all applicable laws, rules and regulations relating to personal and medical information. Without in any way
limiting the foregoing, RECIPIENT maintains and enforces appropriate facility and information technology access rules and procedures to protect against inappropriate disclosure of patient records and all other documents deemed confidential by law,
which are maintained in connection with the Project and Institute-Funded Activities, including provisions that comply with the requirements of the INSTITUTE’s rules, 25 T.A.C. Section 703.14. Upon request from the INSTITUTE, RECIPIENT will
timely furnish a copy of the RECIPIENT’s facility and information technology access rules and procedures, as well as any other applicable confidentiality guidelines. 

If RECIPIENT, including any Collaborators or Contractors, works directly with patients or otherwise has access to or maintains patient personal and medical
information, RECIPIENT specifically addresses Health Insurance Portability and Accountability Act of 1996 regulations concerning confidentiality of personal and medical information. Any disclosure of confidential information in any way related to
the Project (including information that may be required by reports and inspections) must be in accordance with all applicable laws. 
 Section
C1.04    Conduct of Research or Service Provided. RECIPIENT understands that the Project must be conducted with full consideration for the ethical and medical implications of the research performed or services
delivered and comply with all federal and state laws regarding the conduct of the research or service. 
 Section
C1.05    Regulatory Certificates, Licenses and Permits. All personnel, facilities and equipment involved or to be involved in the Project are certified, licensed, permitted, registered or approved by the appropriate
regulating agency, where applicable. Any revocation, surrender, expiration, non-renewal, inactivation or suspension of any such certification, license, permit, registration or approval shall constitute grounds
for Contract termination. 

  
 22 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 Section C1.06    Assurances and Certifications in Accordance with the NIH
Grants Policy Statement: 
  

	 	(a)	 Civil Rights. Compliance with Title VI of the Civil Rights Act of 1964. 

 

	 	(b)	 Handicapped Individuals. Compliance with Section 504 of the Rehabilitation Act of 1973 as amended.

  

	 	(c)	 Sex Discrimination. Compliance with Section 901 of Title IX of the Education Amendments of 1972 as
amended. 

  

	 	(d)	 Age Discrimination. Compliance with the Age Discrimination Act of 1975, as amended.

  

	 	(e)	 Patents, Licenses and Inventions. Compliance with the Standard Patent Rights clauses as specified in 37
CFR, Part 401 or 35 U.S.C. 203, if appropriate and applicable, in a manner that adequately protects the INSTITUTE’S rights in the Project Results. 

  

	 	(f)	 Human Subjects. Compliance with the requirements of federal policy concerning the safeguarding of the
rights and welfare of human subjects who are involved in activities supported by federal funds. Before any funding may be released for any Project involving human subjects, RECIPIENT must receive approval from RECIPIENT’s Institutional Review
Board (IRB). Upon request, a copy of RECIPIENT’s IRB approval must be provided to the INSTITUTE. 

  

	 	(g)	 Human Biological/Anatomical Material. Compliance with the recommendations of the NIH Office of Human
Subject Research Medical Administrative Series (MAS) #MO1-2 entitled “Procurement and Use of Human Biological Materials for Research,” and any other federal or state requirements.

  

	 	(h)	 Use of Animals. Compliance with applicable portions of the Animal Welfare Act (PL 89-544 as amended) and appropriate Public Health Service Policy on Humane Care and Use of Laboratory Animals regulations. Before any funding may be released for any Project involving animal subjects, RECIPIENT must
receive approval from RECIPIENT’s Institutional Animal Care and Use Committee (IACUC). Upon request, a copy of RECIPIENT’s IACUC approval must be provided to the INSTITUTE. 

 

	 	(i)	 Debarment and Suspension. RECIPIENT certifies that neither it nor the Principal Investigator/Project
Director or any other Recipient Personnel or personnel of any Collaborator or Contractor assigned to work on the Project are debarred, suspended, proposed for debarment, declared ineligible or otherwise excluded from participation in the Project by
any federal or state department or agency. 

  

	 	(j)	 Non-Delinquency on Federal or State Debt. RECIPIENT certifies
that neither it, nor any person to be paid from funds under this Contract, is delinquent in repaying any Federal debt as defined by OMB Circular A-129 or any debt to the State of Texas. 

 

	 	(k)	 Eligibility to Receive Payments on State Contracts. RECIPIENT certifies that it and the Principal
Investigator/Project Director are not ineligible to receive the Grant award under this Contract pursuant to Tex. Fam. Code Ann. Section 231.006 and acknowledges that this Contract may be terminated and payment may be withheld if this
certification is inaccurate. 

  

	 	(l)	 Drug-Free Workplace. Compliance with the Drug-Free Workplace Act of 1988 (45 CFR 82).

  

	 	(m)	 Misconduct in Science. Compliance with 42 CFR Part 50, Subpart A, and Final Rule as published at 54 CFR
32446, August 8, 1989. 

  
 23 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

	 	(n)	 Objectivity of Research/Conflict of Interest. Compliance with the NIH requirement to maintain a written
standard of conduct and comply with 42 CFR Part 50, Subpart F, Responsibility of Applicants for Promoting Objectivity in Research. RECIPIENT must notify the INSTITUTE of any conflicting financial interests and assure that the interest has been
managed, reduced or eliminated. 

  

	 	(o)	 Trafficking in Persons. Compliance with the NIH regulations on trafficking in persons as published at
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-08-055.html. 

 

	 	(p)	 Criminal Misconduct. RECIPIENT shall promptly report issues to the INSTITUTE involving potential civil
or criminal fraud related in any way to the Project, the Institute-Funded Activity or this Contract, such as false claims or misappropriation of federal or state funds. 

Section C1.07    Tobacco Free Workplace Policy. Pursuant to T.A.C. 25 § 703.20, RECIPIENT certifies that its board of
directors, governing body, or similar has adopted and enforces a Tobacco-Free Workplace Policy that meets or exceeds all of the following minimum standards: 
  

	 	(a)	 Prohibits the use of all forms of tobacco products, including but not limited to cigarettes, cigars, pipes,
water pipes (hookah), bidis, kreteks, electronic cigarettes, smokeless tobacco, snuff and chewing tobacco; 

  

	 	(b)	 Designates the property to which the policy applies (“designated area”). The designated area(s) must
at least comprise all buildings and structures where the CPRIT project is taking place, as well as the sidewalks, parking lots, walkways, and attached parking structures immediately adjacent but only to the extent the CPRIT Grant Recipient owns,
leases as the sole tenant, or controls the building, sidewalks, parking lots and/or parking structures. In the event that the RECIPIENT does not own, lease as the sole tenant, or control the building, sidewalks, parking lots and/or parking
structures, then the designated area(s) must include all areas under the RECIPIENT’s control; 

  

	 	(c)	 Applies to all employees and visitors in the designated area(s); and 

 

	 	(d)	 Provides for or refers employees to tobacco use cessation services. 

If RECIPIENT cannot meet the minimum standards as set forth in this section, RECIPIENT certifies that it has received an approved waiver from the
INSTITUTE’s CEO for the current fiscal year. 
 Section C1.08    No Donations to the Institute or a Foundation
Established to Support Institute. RECIPIENT certifies that as of June 14, 2013, it has not made and will not make a contribution, during the term of the Contract, to the INSTITUTE or to any foundation established specifically to support the
INSTITUTE. 

  
 24 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 DP160071—Product Development Research Contract Attachment C Part 2 Matching
Compliance 
 Certification (MCC)—Initial 

For Public or Private Institutions of Higher Education ONLY (all other entities proceed to the section below): The grant recipient may credit toward
the matching funds requirement the dollar equivalent to the difference between the institution’s federally approved indirect cost rate for research projects and CPRIT’s [***] indirect cost allowance. If a Public or Private Institution of
Higher Education intends to fulfill its match requirement using expended funds only (no federally approved indirect cost rate credit), then choose “No” on the first question and proceed with the form submission. 

If the grant recipient’s Federally Approved Indirect Cost Rate is greater than or equal to [***] (the [***] matching funds requirement and the [***]
CPRIT Indirect Cost Rate), then no further action is required once the appropriate information has been entered in lines “a” through “d” and in the “Enter Certification of Initial Matching Funds Encumbered” field below.

 If the combined Federally Approved Indirect Cost Rate and the CPRIT Indirect Cost Rate calculated for the Project is less than [***], then the grant
recipient must use the section below to demonstrate that it has encumbered funds available and not yet expended that are dedicated to the CPRIT-funded project for the portion of the match requirement not met by the Federally Approved Indirect Cost
Rate credit. 
  

			
	 Public or Private Institution of Higher Education:

(Choose ‘No’ if You Are Using Encumbered Funds)
	  	 [***]

		
	 Matching funds Requirement + CPRIT Indirect Cost Rate:
	  	 [***]

		
	 Federally Approved Cost Rate for Project for Year 1:
	  	 [***]

	 Percentage to fulfill match requirement for Year 1:
	  	 [***]

	 Certified Year 1 Approved Budget:
	  	 [***]

	 Remaining Dollar amount to fulfill match requirement for the Award year 1:
	  	 [***]

	 Match based on prior year credit/deficiency:
	  	 [***]

	 Enter Certification of Initial Matching Funds Encumbered:
	  	 [***]

 The information above is the entity/Institution’s demonstration of encumbered available funds pursuant to its
certification in Attachment C. The information in the certification shall be updated annually. By approving this form the grant recipient certifies that it has the matching funds available as reflected on the form. 

  
 25 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 ATTACHMENT D 

INTELLECTUAL PROPERTY AND REVENUE SHARING 

This Attachment D is hereby incorporated into and made a part of that certain CANCER RESEARCH GRANT CONTRACT (“Contract”) by
and between the Cancer Prevention and Research Institute of Texas (“CPRIT” or the “INSTITUTE”) and the RECIPIENT. A capitalized term used in this Attachment shall have the meaning given the term in the
Contract or in the Attachments to the Contract, unless otherwise defined herein. In the event of a conflict between the provisions of this Attachment and the provisions of the Contract, this Attachment shall control. 

PART 1 
 OWNERSHIP AND
INTELLECTUAL PROPERTY PROTECTION 
 Section D1.01    Ownership of Project Results. RECIPIENT and its
Collaborators, and (to the extent applicable) any third party participating in the development of the Project Results, shall retain ownership of the Institute-Funded Technology and the Institute-Funded IPR, subject to the terms of the Contract. A
Collaborator as defined in the Contract is not a third party that engages with RECIPIENT as a licensing partner. 
 Section
D1.02    Transfer or Assignment of Rights to a Third Party. RECIPIENT shall notify the INSTITUTE of any proposed transfer or assignment of rights in any Project Results to a third party and provide to INSTITUTE a copy
of the agreement under which the proposed transfer or assignment is to occur. RECIPIENT shall ensure that, in any assignment or transfer of Project Results, the transferee or assignee agrees in writing to: (i) recognize that the
Institute-Funded IPR and Institute-Funded Technology, as applicable, is transferred or assigned subject to the licenses, interests and other rights in such Project Results provided to the INSTITUTE in the Contract and any applicable law or
regulation, (ii) take all actions necessary to protect all such licenses, interests and other rights, and (iii) be responsible for and pay all amounts required under Part 4 of this Attachment D. Any attempted transfer or assignment of
rights in any Project Results to a third party without written agreement to the conditions in (i) – (iii) above shall be null, void and of no effect. 

Section D1.03    Protection of Institute-Funded IPR. Subject to Section D5.01, RECIPIENT shall use commercially reasonable
efforts to appropriately protect the Institute-Funded IPR, including without limitation, diligently seeking registration and maintenance of patents and copyrights covering the Institute-Funded Technology, as appropriate. If RECIPIENT elects to
abandon any patent applications filed or patents issued covering any Institute-Funded Technology in any Major Market Country, RECIPIENT shall provide the INSTITUTE with prior written notice of such election, with sufficient time (but no less than
[***]) for the INSTITUTE to exercise its rights under this Section D1.03 with respect thereto. Upon notice of the aforesaid, the INSTITUTE shall have the right, but not the obligation, to pursue protection of the applicable Institute-Funded
Technology on its own behalf in such Major Market Country, including directing the filing, prosecution and maintenance of patent applications or patents covering the applicable Institute-Funded Inventions in any of such Major Market Countries for
which the INSTITUTE exercises its rights under this Section D1.03. In the Major Market Countries where the INSTITUTE pursues protection of the Institute-Funded Technology under this Section D1.03, RECIPIENT agrees to grant, and does hereby grant, to
the INSTITUTE anon-exclusive, irrevocable, royalty-free, perpetual license with right to sublicense in the applicable Major Market Countries to the applicable Instituted-Funded Technology and any applicable Project Results. For clarification, a
determination by RECIPIENT to (i) abandon a patent application in favor of a continuation or divisional application or the like, or (ii) narrow the scope of the claimed subject matter, shall not be deemed an election to abandon such
Institute-Funded IPR. 
 Section D1.04    Cost of Protection. The INSTITUTE shall not be responsible for, and no Grant
funds may be used to pay for, any costs or expenses associated with RECIPIENT’s efforts to protect the Institute-Funded IPR. 
 Section D1.05
Inventions. 
 (a)    Disclosures and Patent Applications. RECIPIENT shall notify INSTITUTE of each
Institute-Funded Invention by delivering to INSTITUTE a copy of the invention disclosure within [***] after RECIPIENT receives or generates it. In the event that a patent application is filed on the invention disclosure, RECIPIENT shall provide the
INSTITUTE with a complete copy of such patent application and associated filing documents within [***] of its filing. 

  
 26 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 (b)    Patent Prosecution and Maintenance. For all
Institute-Funded Inventions for which patent protection is pursued, RECIPIENT shall provide an annual written report to the INSTITUTE regarding the status of pending applications and issued patents that are Institute-Funded IPR. 

Section D1.06    Required Agreements with Recipient Personnel and Contractors. The RECIPIENT shall have, maintain and
enforce written policies or agreements applicable to Recipient Personnel and Contractors with terms sufficient to enable RECIPIENT to fully comply with all terms and conditions of this Contract, including that Recipient Personnel and Contractors
agree to and hereby assign any Institute-Funded Inventions to RECIPIENT. RECIPIENT shall promptly report to INSTITUTE any material breach of such policies or agreements relating to or affecting any of the provisions of this Contract. 

Section D1.07    Agreements with Collaborators. All agreements between RECIPIENT and a Collaborator, or a third party
participating in the development of the Project Results, relating to or affecting joint ownership of any Project Result shall recognize the licenses, interests and other rights provided to the INSTITUTE in the Contract. RECIPIENT shall provide to
the INSTITUTE a copy of each such agreement affecting joint ownership of any Project Result. 
 PART 2 

NON-COMMERCIAL LICENSES 

Section D2.01    RECIPIENT License. In granting an Exclusive License to any Project Results, RECIPIENT shall retain the
right to Exploit all Project Results (including material embodiments thereof) for education, research and other non-commercial purposes, and the right to grant the licenses pursuant to Section D2.02 below.

 Section D2.02    INSTITUTE License. RECIPIENT agrees to grant, and does hereby grant, to the INSTITUTE a non-exclusive, irrevocable, royalty-free, perpetual, worldwide license with right to sublicense under the Project Results and, subject to any existing third party rights, any Necessary Additional IPR to Exploit all
Project Results (including material embodiments of Project Results) by the INSTITUTE, other governmental entities and agencies of the State of Texas, and private or independent institutions of higher education (as defined by Texas law) located in
Texas, for education, research and other non-commercial purposes only pursuant to industry-standard confidentiality and/or material transfer agreements to be entered into between the parties, as applicable.
RECIPIENT shall make the Institute-Funded Technology available by reasonable means to the INSTITUTE in order for the INSTITUTE to exercise its rights under this Section D2.02, at no cost to RECIPIENT. A copy of any written license granted by
INSTITUTE under this Section D2.02 will be provided to RECIPIENT by INSTITUTE within [***] of the effective date of such license. 
 Section
D2.03    No Implied Licenses. No implied licenses are granted under this Agreement including without limitation any license to any Intellectual Property Rights owned or controlled by RECIPIENT outside of the
Institute-Funded IPR. Nothing in this Agreement shall be construed to impose an obligation on RECIPIENT to license or otherwise make available any of its Intellectual Property Rights or other resources owned or controlled by it except as expressly
provided in this Agreement. 
 PART 3 

COMMERCIALIZATION OF PROJECT RESULTS 

Section D3.01    Commercialization Strategy. RECIPIENT shall be under a continuing obligation throughout the term of this
Contract to enhance and improve the commercial development plan submitted with the Application and to provide an annual written report to the INSTITUTE regarding the RECIPIENT’s and its licensee’s efforts to commercialize or otherwise
bring to practical application Project Results. The INSTITUTE may, at its option and at any time, provide RECIPIENT with comments regarding the RECIPIENT’s commercial development plan and strategy, in which case RECIPIENT shall consider in good
faith and, if appropriate, use reasonable efforts to account for and incorporate the INSTITUTE’s input into such commercial development plan and strategy. 

  
 27 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 Section D3.02    Commercialization Efforts. The RECIPIENT shall, including
whether through its own efforts or the efforts of a licensee under a License Agreement allowed by the terms of this Attachment, use diligent and commercially reasonable efforts to commercialize at least one Commercial Product or Commercial Service
or otherwise bring to practical application the Project Results in accordance with the commercial development plan submitted with the Application and including any changes to such commercial development plan in accordance with Section D3.01. For the
avoidance of doubt, partnering or licensing activities shall be considered to be efforts to commercialize. 
 Section
D3.03    Licensing of Project Results. Each License Agreement entered into by the RECIPIENT shall include an acknowledgement by the licensee that (i) such License Agreement is subject to the INSTITUTE’s
licenses, interests and other rights under this Contract, and (ii) to the extent that there is a conflict between the terms of the License Agreement and the terms of this Contract, the terms of this Contract shall prevail. In addition, all
License Agreements shall include terms obligating the licensee to report to the RECIPIENT such information as is required for the RECIPIENT to fully comply with the terms of the Contract, including without limitation the reporting obligations set
forth in Attachment E, and to allow RECIPIENT to make the grants specified in Sections D2.02. The RECIPIENT shall monitor the performance of its licensees and such licensees’ compliance with the terms of the License Agreements and shall take
commercially reasonable actions to enforce the terms of all License Agreements. The RECIPIENT shall [***] report to the INSTITUTE any material breach of a License Agreement relating to or affecting any of the material provisions of this Contract.

 Section D3.04    Cost of Licensing Activities. The INSTITUTE shall not be responsible for, and no Grant funds may be
used to pay for, any costs or expenses associated with the RECIPIENT’s Licensing Activities. 
 Section
D3.05    Survival. The licenses, rights and obligations set forth in this Attachment D, except Section D3.01, shall survive any termination of this Contract, including any termination for convenience by RECIPIENT. 

Section D3.06    Recipient Opt-Out. In the event RECIPIENT determines, after
diligently attempting to comply with the terms of Section D3.02, to cease its efforts, either directly or through a licensee, to commercialize or otherwise bring to practical application the Project Results, it will so notify the INSTITUTE in
writing promptly thereafter. Such written notice must identify the Project Results and provide a reasonable explanation of the reasons for the RECIPIENT’s election. Upon receipt of such notice, the INSTITUTE and RECIPIENT shall meet within
[***] to review the Project Results and rationale for the RECIPIENT’s election. Provided that RECIPIENT’s determination to cease its efforts was not based on material safety concerns related to the Project Results, the INSTITUTE and
RECIPIENT shall engage in good faith negotiations regarding an alternative commercialization strategy and/or revenue sharing approach. 
 The INSTITUTE and
RECIPIENT may consider, among other options, an award of equity in the RECIPIENT, expansion or modification of the Institute Funded Activity to cover other commercial products or commercial services being advanced by the RECIPIENT, or some
combination thereof. Unless otherwise agreed, if the INSTITUTE and RECIPIENT are unable to achieve an alternative strategy or agreement within [***] of the RECIPIENT’s initial notice of election, and provided that RECIPIENT’s determination
to cease its efforts was not based on material safety concerns related to the Project Results, the INSTITUTE shall have the right, but not the obligation, to exercise its rights in Section D5.01 in relation to the Project Results at the
INSTITUTE’s expense. If the INSTITUTE elects to exercise its rights under Section D5.01 in relation to the Project Results, the INSTITUTE shall notify the RECIPIENT in writing within the later of [***] of INSTITUTE’s receipt of the
RECIPIENT’s initial notice of election or [***] following a declaration by one of the Parties that good faith negotiations have failed. In the event that the INSTITUTE exercises its option under this Section D3.06, the RECIPIENT shall cooperate
with the INSTITUTE’s efforts and provide to INSTITUTE sufficient information such as relevant feasibility studies, trial results, regulatory summaries, and pertinent schedules or deadlines in relation to the Project Results, in commercializing
or otherwise bringing to practical application the applicable Project Results at the INSTITUTE’s cost. For clarity, so long as the RECIPIENT is making efforts to commercialize at least one Commercial Product or Commercial Service, RECIPIENT
shall have no obligation to provide the written notice as described in this Section D3.06. 

  
 28 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 PART 4 

REVENUE SHARING 
 Section
D4.01    Revenue Sharing Percentages. In consideration for the Grant Award Proceeds paid to the RECIPIENT by the INSTITUTE under the Contract: 

a.    RECIPIENT shall pay to the INSTITUTE during the Revenue Term the following payments until the INSTITUTE receives the
aggregate amount of four hundred percent (400%) of the Grant Award Proceeds: 
 (i)      a
revenue sharing percentage of [***] of Revenue for Cumulative Revenue greater than [***] and less than or equal to [***]; 

(ii)     a revenue sharing percentage of [***] of Revenue for Cumulative Revenue greater than [***]
and less than or equal to [***]; and 
 (iii)    a revenue sharing percentage of [***] of Revenue for
Cumulative Revenue greater than [***]. 
 For clarity, no payments will be made by the RECIPIENT to the INSTITUTE under this Section D4.01(a) until the
Cumulative Revenue of the Recipient is greater than [***]. 
 b. In the event the RECIPIENT and/or its licensee is required to obtain a
license under Intellectual Property Rights of one or more Third Parties in order to make Sales of Commercial Products and/or Commercial Services in any given country (“Participating License Sources”), then the revenue sharing
percentages set forth under Section D4.01(a)(i)-(iii) may be reduced by [***] for every [***] royalty paid to such Third Parties on Commercial Products and/or Commercial Services in such country, as applicable, provided that in no event will the
payments otherwise due to the INSTITUTE under Section D4.01(a) be less than [***] of the payments that would be payable to the INSTITUTE absent the effects of this Section D4.01(b). By way of example, if the RECIPIENT is required to obtain such a
license from a Third Party in a country wherein the RECIPIENT pays a [***] royalty for Intellectual Property Rights that cover Commercial Products and Commercial Services in such country, the revenue sharing percentages under Section D4.01(a)(i),
(ii), and (iii) would be reduced to [***] in such country, respectively. 
 Section D4.02    Continued Revenue
Sharing. In the event the INSTITUTE receives during the Revenue Term the aggregate amount of four hundred percent (400%) of the Grant Award Proceeds from the RECIPIENT, the RECIPIENT will continue to pay the INSTITUTE a revenue sharing
percentage of one-half percent (0.5%) of Revenue for all Revenue generated during the remainder of the Revenue Term. For clarity, this revenue sharing percentage cannot be reduced as set forth in Section
D4.01(b). 
 Section D4.03    Equity. Nothing herein prohibits the INSTITUTE from negotiating with the RECIPIENT for an
equity share in the RECIPIENT in addition to or in lieu of the revenue sharing set forth in Sections D4.01 and D4.02, when mutually agreed to by the INSTITUTE and the RECIPIENT. But under no circumstances is the INSTITUTE obligated to negotiate for
an equity share in the RECIPIENT in lieu of the revenue sharing set forth herein. 
 Section D4.04     Statements and Timing
of Payments. All payments owed pursuant to this Part 4 shall be made to the Cancer Prevention and Research Institute of Texas, and are payable on or before the thirtieth day following the end of the calendar quarter in which the Revenue is
received or, in the case of Section D4.05, the monetary recovery is received. For each payment specified in Sections D4.01 and D4.02, the payment shall be accompanied by a statement specifying for such calendar quarter: (i) the Contract to
which the payment relates, (ii) the identities of, royalty percentages, and amounts actually paid to any Participating License Sources, (iii) the License Agreements, if any, to which the payment relates, (iv) the quantity of all Sales
of each Commercial Product and Commercial Service since the last payment, if Sales are applicable to the current payment, (v) the gross consideration from all such Sales, if Sales are applicable to the current payment, and (vi) a
calculation of the amount of the payment to the Cancer Prevention and Research Institute of Texas. 

  
 29 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 Section D4.05    Recoveries in Enforcement Actions. In the event that the
RECIPIENT receives any monetary recovery from its enforcement of Institute-Funded IPR against infringement by a third party, then it shall pay to the State of Texas a share of such monetary recovery, including any punitive damages, less the
documented fees and expenses that are directly associated with such enforcement and are paid by RECIPIENT to third parties, at the same rate and in the same manner as it shares Revenue pursuant to Sections D4.01 and D4.02 (including any adjustments
allowed by Section D4.01(b)). For clarity, if the enforcement action is resolved by way of the execution of a License Agreement with the allegedly infringing third party and such License Agreement is consistent with this Part 4, then this Section
D4.05 is not intended to apply to such License Agreement or the consideration specified therein. 
 Section
D4.06    Revenue-Related Records. In addition to satisfying the requirements of Article IV of the Contract and Section E1.03 of Attachment E, the RECIPIENT shall keep complete and accurate Revenue-related records until
the fourth anniversary of the date of the payment of the last payment owed hereunder, in sufficient detail to permit the INSTITUTE to confirm the accuracy of the statements delivered to the INSTITUTE under Section D4.04 and the calculation of the
payments owed hereunder. 
 Section D4.07    Audit of Revenue-Related Records. Upon at least fifteen (15) days’
advance written notice, the RECIPIENT shall permit the INSTITUTE or its representatives or agents, at the INSTITUTE’s expense, to examine the Revenue-related records of the RECIPIENT pursuant to Section D4.06 once per calendar year during
regular business hours for the purpose of and to the extent necessary to verify the RECIPIENT’s compliance with this Part 4. The rights of the INSTITUTE under this Section D4.07 shall terminate on the fourth anniversary of the date of the
payment of the last payment owed hereunder. In the event that any such examination reveals an underpayment to the INSTITUTE of greater than [***] of the amounts previously paid by the RECIPIENT to the INSTITUTE, then the RECIPIENT shall reimburse
the INSTITUTE for the cost of such examination. 
 PART 5 

OPT-OUT AND DEFAULT 

Section D5.01    RECIPIENT Opt-Out. If the INSTITUTE elects to exercise its rights
in relation to the Project Results under Section D3.06, the INSTITUTE shall have the right, but not the obligation, to pursue protection of the Applicable Institute-Funded IPR on its own behalf, including directing the filing, prosecution and
maintenance of patents covering the applicable Institute-Funded Inventions and/or to commercialize or otherwise bring to practical application Project Results covered by the Applicable Institute-Funded IPR, at its own cost, either directly or
through one or more licensees. For the purposes of this Part 5, “Applicable Institute-Funded IPR” shall mean all Project Results. If the INSTITUTE elects to exercise any such rights under this Section D5.01, it shall notify RECIPIENT in
writing pursuant to the notification requirements in Section D3.06 and RECIPIENT shall thereafter comply with the terms of Section D5.03 with regard to the Applicable Institute-Funded IPR. 

Section D5.02    RECIPIENT Default. In the event that the INSTITUTE notifies RECIPIENT in writing of RECIPIENT’s
failure to materially comply with its obligations under Section D3.02, and RECIPIENT fails within [***] of such notice either: (a) to cure such failure, or in the event that such failure cannot be reasonably cured within such [***] period, to
provide to INSTITUTE a plan to cure such failure that INSTITUTE deems acceptable, (b) to provide written notice to the INSTITUTE that such failure was due to material safety concerns, or (c) to provide proper notice pursuant to
Section 3.06, then without further action on the part of the RECIPIENT or INSTITUTE, the RECIPIENT shall be deemed to have provided the INSTITUTE the complete, written notice of its cessation of efforts as described in Section 3.06, and
the INSTITUTE shall be free to exercise its rights under Section 3.06. 

  
 30 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 Section D5.03    RECIPIENT Cooperation upon
Opt-Out or Default. In the event that the INSTITUTE exercises any of its rights under Section D5.01, the RECIPIENT shall: 
  

	 	(1)	 subject to [***], transfer and assign, and does hereby assign, all of its right, title and interest in and to
the applicable Project Results to the INSTITUTE or the INSTITUTE’s designee, to the maximum extent allowed by law, including where relevant and necessary to facilitate the foregoing transfer, requesting and diligently attempting to obtain any
approvals required by law or otherwise in relation to such transfer, and subject to [***], hereby grants to the INSTITUTE a non-exclusive, royalty-free, perpetual, fully transferable and sublicensable license
under any Institute-Funded Technology and Necessary Additional IPR to Exploit the Project Results for the development, manufacture and sale of Commercial Products and Commercial Services and for all other purposes reasonably related thereto;

  

	 	(2)	 to the extent that RECIPIENT is unable to transfer all of its right, title and interest in and to the
applicable Project Results to the INSTITUTE as specified in Section D5.03(1), and subject to [***], RECIPIENT hereby grants to the INSTITUTE an exclusive, royalty-free, perpetual, fully transferable and sublicensable license under the Applicable
Institute-Funded IPR to Exploit the Project Results for the development, manufacture and sale of Commercial Products and Commercial Services and for all other purposes reasonably related thereto, provided that the INSTITUTE may exercise the
foregoing rights only after exercising its right under Section D5.01; 

  

	 	(3)	 cooperate with the INSTITUTE’s efforts, and at the INSTITUTE’s cost, in protecting Applicable
Institute-Funded IPR and Institute-Funded Technology, and in commercializing or otherwise bringing to practical application the applicable Project Results, including making relevant Recipient Personnel (to the extent still obligated to RECIPIENT),
Contractors, Collaborators, records (including without limitation, laboratory notebooks, electronic records and data), papers, information, samples, specimens and other materials related to the applicable Project Results reasonably available for
such purposes and executing any documents and taking any further action reasonably necessary to effectuate the intent of this Section D5.03; and 

  

	 	(4)	 subject to applicable law, not take any action that would oppose or impede the INSTITUTE’s ability to
protect the applicable Project Results. 

 If the INSTITUTE exercises its rights under Sections D5.01, the RECIPIENT shall have no further
claim to or interest in the applicable Project Results, except as set forth in Section D2.01 of this Attachment and shall not be entitled to any share of Revenue or any other compensation with respect to such Project Results, except to the minimum
extent required by law, if any. To the extent that the INSTITUTE has exercised its rights under Section D5.01 and RECIPIENT is unable to transfer all of its right, title and interest in and to the applicable Project Results to the INSTITUTE as
specified in D5.03(1), then the INSTITUTE’s license set forth in D5.03(2) includes the right, but not the obligation, for the INSTITUTE at its cost to: (i) direct the filing, prosecution and maintenance of patents covering the applicable
Project Results, and (ii) enforce all Applicable Institute-Funded IPR relevant to the Project Results against any infringement by a third party. Subject to the statutory duties of the Texas Attorney General, if any, RECIPIENT shall cooperate
fully with the INSTITUTE in any action brought by the INSTITUTE to enforce the Institute-Funded IPR in the applicable Project Results, at the INSTITUTE’s cost, including without limitation, joining the enforcement action in name as a party
plaintiff after all required approvals are obtained; provided that the INSTITUTE or its designee shall have full control over such enforcement action and shall receive and retain all monetary and other recoveries resulting from such enforcement
actions, including any punitive damages. 
 PART 6 

DEFINITIONS 
 Throughout this
Attachment D, the following underlined terms shall have the meanings given below. 
 (1)    Commercial Product
means anything that is based on, utilizes or is developed from, or materially incorporates, the Project Results and that is capable of being sold, licensed, transferred or conveyed to another party or is capable of otherwise being Exploited or
disposed of, whether in exchange for consideration or not. 

  
 31 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 (2)    Commercial Service means any service performed that is based
on, utilizes or is developed from, or materially incorporates, the Project Results. For clarity, Commercial Service does not include non-commercial research and development performed by RECIPIENT or its Collaborators or licensees. 

(3)    Cumulative Revenue means after the First Commercial Sale worldwide of a Commercial Product or Commercial
Service, the sum of all Revenue in all years and calendar quarters up to the calendar quarter in which the applicable revenue sharing percentage in Section D4.01 is being paid. 

(4)    Exclusive License means a License Agreement under which the specific rights granted to the licensee with
respect to the Project Results, including without limitation scope of use and territorial rights, are granted on an exclusive basis. 

(5)    Exclusivity means any exclusivities granted by the government in a country to provide an entity with
protection from competitors in the commercial market for a defined period of time, including but not limited to patent-based exclusivities (and any patent term extensions, supplementary protection certificates or patent term adjustments thereof, and
the like), and market-based “data” exclusivities (e.g., orphan drugs, new chemical entities, biologics, new formulations or combinations, and pediatric, and the like). For the avoidance of doubt, Exclusivity shall not mean any protection
gained solely from either trade secrets or trademarks. 
 (6)    Exploit or Exploitation means make,
have made, use, sell, offer to sell, import, export, or otherwise commercialize, dispose of, practice, copy, distribute, create derivative works of, publicly perform or publicly display. 

(7)    First Commercial Sale means the first bona fide arm’s length Sale of a Commercial Product or Commercial
Service to a Third Party by or on behalf of RECIPIENT or its licensees for monetary value, for use or consumption by the end user of such Commercial Product or Commercial Service. For clarity, Sales of a Commercial Product or Commercial Service for
registration samples, clinical trial purposes or compassionate use sales, named patient use, test marketing, sampling and promotional uses, inter-company transfers to affiliates of RECIPIENT or its licensees, shall not constitute a First Commercial
Sale. 
 (8)    Grant Award Proceeds means the sum of all monies paid by INSTITUTE to RECIPIENT under the Contract.
For clarity, Grant Award Proceeds will not be diminished by the amount of any funds repaid to INSTITUTE by RECIPIENT under Section 4.07 of the Contract. 

(9)    Institute-Funded IPR means any and all Intellectual Property Rights in and to Institute-Funded Technology. In
no event shall Institute-Funded IPR include any intellectual property rights and/or technology in existence and owned/controlled by the RECIPIENT prior to the receipt of funds from the INSTITUTE or arising from activities conducted independently of
the Project or acquired independently of the Project. 
 (10)    Institute-Funded Invention means an Invention
conceived or first reduced to practice by or on behalf of RECIPIENT, including by Recipient Personnel, Contractor(s) and/or Collaborator(s) in the performance of Institute-Funded Activity. 

(11)    Institute-Funded Technology means any and all of the following resulting or arising, in whole or in part,
from Institute-Funded Activity during the Contract term: (a) proprietary and confidential information, including but not limited to data, trade secrets, materials and know-how; (b) databases,
compilations and collections of data; (c) tools, methods and processes; and (d) works of authorship, excluding all scholarly works, but including, without limitation, computer programs, source code and executable code, whether embodied in
software, firmware or otherwise, documentation, files, records, data and mask works; and all instantiations of the foregoing in any form and embodied in any form, including but not limited to therapeutics, drugs, drug delivery systems, drug
formulations, devices, diagnostics, biomarkers, reagents, methodologies and research tools. Institute-Funded Technology includes Institute-Funded Inventions. Institute-Funded Technology shall not include items that were conceived of, in existence,
or owned/controlled by RECIPIENT prior to receipt of funds from the INSTITUTE or arising from activities conducted independently of the Project or acquired independently of the Project, such as: (a) proprietary and confidential information,
including but not limited to data, trade secrets, materials and know-how; (b) databases, 

  
 32 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 
compilations and collections of data; (c) tools, methods and processes; and (d) works of authorship, excluding all scholarly works, but including, without limitation, computer programs,
source code and executable code, whether embodied in software, firmware or otherwise, documentation, files, records, data and mask works; and all instantiations of the foregoing in any form and embodied in any form, including but not limited to
therapeutics, drugs, drug delivery systems, drug formulations, devices, diagnostics, biomarkers, reagents, methodologies and research tools. 

(12)    Intellectual Property Rights or IPR means any and all of the following and all rights in,
arising out of, or associated therewith: (a) all United States and foreign patents and utility models and applications therefor, and all reissues, re-examinations, divisionals, renewals, substitutions,
extensions, provisionals, continuations and continuations-in part thereof, and equivalent or similar rights anywhere in the world in inventions and discoveries; (b) all trade secrets and rights in know-how, materials and proprietary information; (c) all copyrights, copyright registrations and applications therefor, and all other rights corresponding thereto throughout the world; (d) all mask works,
mask work registrations and applications therefor, and any equivalent or similar rights in semiconductor masks, layouts, architectures or topology; and (e) any similar, corresponding or equivalent rights to any of the foregoing anywhere in the
world. 
 (13)    Invention means any idea, composition of matter, method, device, process or discovery that is
conceived and/or reduced to practice, whether patentable or not. 
 (14)    License Agreement means an agreement by
which an owner of a Project Result grants any right to Exploit such Project Result to a Third Party in exchange for consideration. 

(15)    Licensing Activities means the efforts of RECIPIENT or its Collaborator to negotiate, execute or enforce a
License Agreement. 
 (16)    Major Market Country means one or more of the following: [***]. 

(17)    Necessary Additional IPR means any Intellectual Property Rights (a) owned by RECIPIENT, and
(b) identified by the Institute and agreed to in writing by RECIPIENT, that are not Project Results but are necessary to Exploit the Project Results for the specific purposes set forth in the applicable Section of this Attachment D. 

(18)    Project Results means any and all Institute-Funded Technology and Institute-Funded IPR. 

(19)    Revenue means the gross consideration, whether cash (for example, but not by way of limitation, any milestone
fees, license fees, sublicense fees, or assignment fees) or non-cash (for example, but not by way of limitation, securities, direct equity interest, indirect equity interest, trade or barter considerations,
and the like), received from Sales to a Third Party by or on behalf of the RECIPIENT and its licensees (including RECIPIENT’s affiliates and sublicensees of RECIPIENT’s licensee), net of: (a) trade or quantity discounts or rebates,
credits, allowances or refunds given for rejected or returned Commercial Products or Commercial Services, (b) any sales, value-added or other tax or governmental charge levied on the sale, transportation or delivery of a Commercial Product or
Commercial Service (but excluding any income tax owed by the RECIPIENT), and (c) any separately stated charges for freight, postage, shipping and insurance. The foregoing notwithstanding, any consideration: (i) received and used by
RECIPIENT or its licensees for the purpose of research or development of Commercial Products and Commercial Services, or (ii) received from Sales made solely in the performance of clinical trials designed to obtain regulatory approval for a
Commercial Product or Commercial Service, or (iii) received by RECIPIENT or its licensees from Sales made for compassionate use where no profit was obtained by RECIPIENT or its licensees shall not be included in this term. 

(20)    Revenue Term means the period commencing on the date of the First Commercial Sale of a Commercial Product or
Commercial Service and ending, on a country-by-country basis, when there is not, or there no longer exists, any Exclusivity for the Commercial Product or Commercial
Service in such country. If there is no Exclusivity for a Commercial Product or Commercial Service in any Major Market Country, the Revenue Term shall mean the period commencing on the date of the First Commercial Sale of such Commercial Product or
Commercial Service and ending twelve (12) years later. 

  
 33 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 (21)    Sale or Sales means any sale, license, lease,
transfer, conveyance or other Exploitation or disposition of a Commercial Product or Commercial Service for which consideration from a first Third Party is received. For clarity, transfer or assignment of a Commercial Product or Commercial Service
in connection with a merger, consolidation, transfer or sale of all, or substantially all, of RECIPIENT’s business or assets, or change of control or similar transaction involving the RECIPIENT will not constitute a Sale. 

(22)    Third Party means a party other than (a) the RECIPIENT, (b) any affiliate or licensee of the
RECIPIENT, either directly or through any sublicenses, or (c) an entity that enjoys any special course of dealing with any of (a) or (b) above. 

Other terms may be defined elsewhere in this Attachment or in the Contract. 

  
 34 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 

 
 ATTACHMENT E 

REPORTING REQUIREMENTS 
 This Attachment E
is hereby incorporated into and made a part of that certain CANCER RESEARCH GRANT CONTRACT (“Contract”) by and between the Cancer Prevention and Research Institute of Texas (“CPRIT” or the
“INSTITUTE”) and the RECIPIENT. A capitalized term used in this Attachment shall have the meaning given to term in the Contract or in the Attachments to the Contract, unless otherwise defined herein. In the event of a conflict
between the provisions of this Attachment and the provisions of the Contract, this Attachment shall control. 
 INSTITUTE and RECIPIENT agree as follows:

 ANNUAL REPORTING 
 Section
E1.01    Annual Reports. The RECIPIENT shall submit reports annually to the INSTITUTE within [***] of the anniversary of the Effective Date of this Contract or at such other time as may be specified herein. The reports
shall be submitted by the means and in the form(s) required by the INSTITUTE and shall be signed by the Principal Investigator/Program Director and the RECIPIENT’s Authorized Signing Official. To the extent possible, the reports shall only
include information that may be shared publicly. However, if it is necessary to submit information in the reports that the RECIPIENT considers confidential in order to fully comply with the terms of this Contract, then the RECIPIENT shall use
reasonable efforts to mark such information as “confidential” and shall, to the extent practicable, to segregate such information within the reports to facilitate its redaction should redaction ever be necessary or appropriate. 

Section E1.02    Contents of Reports. Each report shall contain a signed verification (electronic signature is acceptable)
of RECIPIENT’s compliance with each of its obligations as set forth in the Contract and shall include the following for the period covered by such report, as may then be applicable: 

 

	(a)	 Project Data. During the term of the Contract, RECIPIENT shall include in its annual report each of the
following (except that the final annual report due under this part (a) shall be due within [***] after the end of the term of the Contract): 

  

	 	(1)	 A brief statement of the progress made to under the Scope of Work, including the progress to achieve the
Project Goals and Timelines set forth in Attachment A. 

  

	 	(2)	 A brief statement of the Project Goals for the twelve months following submission of the report.

  

	 	(3)	 New jobs created in the preceding twelve month period as a result of the Grant funds awarded to RECIPIENT.

  

	 	(4)	 An inventory of the Equipment purchased for the Project using Grant funds. 

 

	 	(5)	 A HUB report in accordance with Section 3.08 “Historically Underutilized Businesses” of the
Contract. 

  

	(b)	 Commercialization Data. During the term of the Contract and continuing thereafter for so long as
RECIPIENT has ongoing obligations to the INSTITUTE with respect to protection, development, commercialization and licensing of Project Results pursuant to Attachment D, RECIPIENT shall provide information about commercialization activities in a
format specified by the INSTITUTE. 

  

	(c)	 Revenue Sharing Data. During the term of the Contract and continuing thereafter for so long as RECIPIENT
has ongoing obligations to the INSTITUTE with respect to revenue sharing pursuant to Attachment D: 

  

	 	(1)	 A statement of the identities of the funding sources, amounts and dates of funding for all funding sources for
the Project. 

  

	 	(3)	 A brief statement of the RECIPIENT’s efforts to secure additional funds to support the Project.

  
 35 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

	 	(4)	 All financial information necessary to verify the calculation of the revenue sharing amounts specified in
Attachment D. 

  

	(d)	 Additional Data. In addition to the foregoing, RECIPIENT shall use commercially reasonable efforts to
also promptly report any other information required by this Contract or otherwise reasonably requested by the INSTITUTE, the Legislature, or any other funding or regulatory bodies covering the RECIPIENT’s activities under this Contract.

 Section E1.03 Record Keeping and Audits. The provisions of Article IV of the Contract shall apply fully to all information
reported to the INSTITUTE pursuant to this Attachment, except that the right of the State of Texas to audit and the RECIPIENT’s obligation to maintain Records shall continue until four years after the date of each such report made by RECIPIENT
hereunder. 
 Section E1.04 Confidentiality of Documents and Information. The provisions of Section 2.13 “Confidentiality of Documents and
Information” of the Contract shall apply fully to all Confidential Information reported, delivered or submitted to the INSTITUTE pursuant to this Attachment E. 

  
 36 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 Grant ID: 

DP160071 
 PI/PD/CR: Jason Kim

 Organization: Molecular Templates, Inc. 
  

 
  
 

 
 Approved Contract Documents 

 

					
	 Title
	  	 Approved By
	  	 Approved Date

	 Product Development Base Contract
	  	 Kim, Jason
	  	 04 Sep 2018

	 Attachment A—Goals and Objectives
	  	 Nelson, Lisa
	  	 06 Sep 2018

	 Attachment B—Verification Request of Contract Document
	  	 Kim, Jason
	  	 07 Sep 2018

	 Attachment C Part 1—Assurances and Certifications
	  	 Kim, Jason
	  	 31 Aug 2018

	 Attachment C Part 2—Matching Compliance Certification
	  	 Lansdowne, Bob
	  	 07 Sep 2018

	 Attachment D—Intellectual Property and Revenue Sharing
	  	 Kim, Jason
	  	 04 Sep 2018

	 Attachment E—Reporting Requirements
	  	 Kim, Jason
	  	 04 Sep 2018

	 Chief Executive Officer Approval
	  	 Roberts, Wayne
	  	 18 Sep 2018

  
 37 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

			
	 Grant ID: DP160071
 Attachment F – CPRIT
Contact Change Notification
	  	PI/PD/CR: Jason Kim
		  	

  

 As indicated by the signatures below, the INSTITUTE and the RECIPIENT agree to the following amendments to
the CPRIT Contract: 
 Contract Document F: I. Amendments to CANCER RESEARCH GRANT CONTRACT (A) In Article 1, DEFINITIONS, delete Section (6)
(Institute-Funded Activity) in its entirety and replace it with amended Section (6) shown below: (6) Institute-Funded Activity - all aspects of work funded by the Institute and conducted as part of the Project as set forth in the Project
Description and/or Scope of Work (Attachment A). (B) In Article 1, DEFINITIONS, amend Section (9) (Project), after “the activities specified” to delete the term “or generally” and replace it with -- and --. Amended Section
(9) is shown below: (9) Project - the activities specified and described in the Scope of Work or otherwise in this Contract (including without limitation any of the Attachments to the Contract) that are approved by the INSTITUTE for
funding, regardless of whether the of the financial support necessary to carry them out. II. Amendments to Attachment A: PROJECT DESCRIPTION, GOALS AND TIMELINES (SCOPE OF WORK) – (A) On the Timeline page of Attachment A, insert the
following note in the [***]. III. Amendments to Attachment D: INTELLECTUAL PROPERTY AND REVENUE SHARING (A) In Part 1, Section D1.01, delete the section in its entirety and replace it with amended Section D1.01 shown below:
Section D1.01 Ownership of Project Results. RECIPIENT and its Collaborators, and (to the extent applicable) any third party participating in the research, development or commercialization of [***], shall with respect to INSTITUTE [***]
Institute-Funded Technology and the Institute-Funded IPR, subject to the terms of the Contract. (B) In Part 1, Section D1.02, first sentence, delete “third Party” and replace with --Third Party--; after “or transfer or
assignment is to occur,” insert -- under provisions of confidentiality and redacted for (a) [***] and (b) other confidential subject matter on a case-by-case
basis with approval of the INSTITUTE. --; and in the second sentence, move “to” (after “writing”) to directly follow “(i)”; insert “to” directly after (ii); directly after (iii), delete “be responsible
for and pay” and replace it with -- that --; and after “under Part 4 of this Attachment D,” insert -- will be paid by[***]. Amended Section D1.02 is shown below: Section D1.02 Transfer or Assignment of Rights to a Third
Party. RECIPIENT shall notify the INSTITUTE of any proposed transfer or assignment of rights in any Project Results to a Third Party and provide to INSTITUTE a copy of the agreement under which the proposed transfer or assignment is to occur, under
provisions of confidentiality and redacted for (a) [***] and (b) other confidential subject matter on a case-by-case basis with approval of the INSTITUTE. RECIPIENT
shall ensure that, in any assignment or transfer of Project Results, the transferee or assignee agrees in writing: (i) to recognize that the Institute-Funded IPR and Institute-Funded Technology, as applicable, is transferred or assigned subject
to the licenses, interests and other rights in such Project Results provided to the INSTITUTE in the Contract and any applicable law or regulation, (ii) to take all actions necessary to protect all such licenses, interests and other rights, and
(iii) that all amounts required under Part 4 of this Attachment D will be paid [***]. Any attempted transfer or assignment of rights in any Project Results to a Third Party without written agreement to the conditions in (i) – (iii) above
shall be null, void and of no effect. (C) In Part 1, Section D1.03, first sentence, after “RECIPIENT shall use commercially reasonable efforts,” insert -- including, as applicable, [***], --; and in the third sentence, after
“Upon notice of the aforesaid, the INSTITUTE shall have the right, but not the obligation,” insert -- subject to IPR ownership rights of [***] and [***] in and to [***], --. Amended Section D1.03 is shown below: Section D1.03
Protection of Institute-Funded IPR. Subject to Section D5.01, RECIPIENT shall use commercially reasonable efforts, including, as applicable, [***], to appropriately protect the Institute-Funded IPR, including without limitation, diligently
seeking registration and maintenance of patents and copyrights covering the Institute-Funded Technology, as appropriate. If RECIPIENT elects to abandon any patent applications filed or patents issued covering any Institute-Funded Technology in any
Major Market Country, RECIPIENT shall provide the INSTITUTE with prior written notice of such election, with sufficient time (but no less than [***]) for the INSTITUTE to exercise its rights under this Section D1.03 with respect thereto. Upon
notice of the aforesaid, the INSTITUTE shall have the right, but not the obligation, subject to IPR ownership rights of [***] and [***] in and to [***], to pursue protection of the applicable Institute-Funded Technology on its own behalf in such
Major Market Country, including directing the filing, prosecution and maintenance of patent applications or patents covering the applicable Institute-Funded Inventions in any of such Major Market Countries for which the INSTITUTE exercises its
rights under this Section D1.03. In the Major Market Countries where the INSTITUTE pursues protection of the Institute-Funded Technology 

  
 38 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

			
	 Grant ID: DP160071
 Attachment F – CPRIT
Contact Change Notification
	  	PI/PD/CR: Jason Kim
		  	

  

 
under this Section D1.03, RECIPIENT agrees to grant, and does hereby grant, to the INSTITUTE a non-exclusive, irrevocable, royalty-free, perpetual
license with right to sublicense in the applicable Major Market Countries to the applicable Instituted-Funded Technology and any applicable Project Results. For clarification, a determination by RECIPIENT to (i) abandon a patent application in
favor of a continuation or divisional application or the like, or (ii) narrow the scope of the claimed subject matter, shall not be deemed an election to abandon such Institute-Funded IPR. (D) In Part 1, Section D1.05(a), first
sentence, after “within [***] after RECIPIENT receives or generates it” insert -- , unless agreed to otherwise by INSTITUTE --. Amended Section D1.05(a) is shown below: Section D1.05 Inventions. (a) Disclosures and Patent
Applications. RECIPIENT shall notify INSTITUTE of each Institute-Funded Invention by delivering to INSTITUTE a copy of the invention disclosure within [***] after RECIPIENT receives or generates it, unless agreed to otherwise by INSTITUTE. In the
event that a patent application is filed on the invention disclosure, RECIPIENT shall provide the INSTITUTE with a complete copy of such patent application and associated filing documents within [***] of its filing. (E) In Part 2,
Section D2.01, first sentence, after “(including material embodiments thereof” insert -- [***] --. Amended Section D2.01 is shown below: Section D2.01 RECIPIENT License. In granting an Exclusive License to any Project
Results, RECIPIENT shall retain the right to Exploit all Project Results (including material embodiments thereof [***]) for education, research and other non-commercial purposes, and the right to grant the
licenses pursuant to Section D2.02 below. (F) In Part 2, Section D2.02, delete this section in its entirety and replace with the following amended Section D2.02, as shown below: Section D2.02 INSTITUTE License.
RECIPIENT hereby grants to the INSTITUTE a non-exclusive, irrevocable, royalty-free, perpetual, worldwide license, solely for academic, non-commercial purposes, under
the Project Results and to Exploit any Necessary Additional IPR, said license specifically [***], and with a right to sublicense to a permitted sublicensee of the INSTITUTE, consisting of other governmental entities and agencies of the State of
Texas, and private or independent institutions of higher education (as defined by Texas law) located in Texas, for education, research and other non-commercial purposes only, pursuant to industry-standard
confidentiality and/or material transfer agreements to be entered into between the parties, as applicable. RECIPIENT shall make all non-excluded Institute-Funded Technology available by reasonable means to the
INSTITUTE in order for the INSTITUTE to exercise its rights under this Section D2.02, at no cost to RECIPIENT. A copy of any written sublicense granted by INSTITUTE under this Section D2.02 will be provided to RECIPIENT by INSTITUTE within
[***] of the effective date of such sublicense. (G) In Part 2, Section D2.03, delete this section in its entirety and replace with the following amended Section D2.03, as shown below: Section D2.03 No Implied Licenses. No
implied licenses are granted under this Contract including without limitation any license to any Intellectual Property Rights owned or controlled by RECIPIENT or [***] or [***] outside of the Institute-Funded IPR. Nothing in this Attachment D to the
Contract shall be construed to impose an obligation on RECIPIENT to license or otherwise make available any of its Intellectual Property Rights or other resources owned or controlled by it except as expressly provided in this Attachment. (H) In
Part 3, Section D3.01, first sentence, delete “enhance” and replace it with -- implement --; and after “to commercialize or otherwise bring to practical application” insert -- at least one Commercial Product directed to the
molecular target described in the --. Amended Section D3.01 is shown below: Section D3.01 Commercialization Strategy. RECIPIENT shall be under a continuing obligation throughout the term of this Contract to implement and improve the
commercial development plan submitted with the Application and to provide an annual written report to the INSTITUTE regarding the RECIPIENT’s and its licensee’s efforts to commercialize or otherwise bring to practical application at least
one Commercial Product [***] Project Results. The INSTITUTE may, at its option and at any time, provide RECIPIENT with comments regarding the RECIPIENT’s commercial development plan and strategy, in which case RECIPIENT shall consider in good
faith and, if appropriate, use reasonable efforts to account for and incorporate the INSTITUTE’s input into such commercial development plan and strategy. (I) In Part 3, Section D3.02, second sentence, after “considered to
be” insert -- diligent and commercially reasonable efforts --. Amended Section D3.02 is shown below: Section D3.02 Commercialization Efforts. The RECIPIENT shall, including whether through its own efforts or the efforts of a licensee
under a License Agreement allowed by the terms of this Attachment, use diligent and commercially reasonable efforts to commercialize at least one Commercial Product or Commercial Service or otherwise bring to practical application the Project
Results in accordance with the commercial development plan submitted with the Application and including any changes to such commercial development plan in accordance with Section D3.01. For the avoidance of doubt, partnering or licensing
activities shall be considered to be diligent and 

  
 39 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

			
	 Grant ID: DP160071
 Attachment F – CPRIT
Contact Change Notification
	  	PI/PD/CR: Jason Kim
		  	

  

 
commercially reasonable efforts to commercialize. (J) In Part 3, Section D3.03, first sentence, delete “(i)”; at line 4, after “Contract,” delete “[***] and
replace with -- [***] --; in the second sentence, after “the reporting obligations set forth in Attachment E” insert -- to this Contract --; and after the last sentence, insert -- “[***] -- Amended Section D3.03 is shown below:
Section D3.03 Licensing of Project Results. Each License Agreement entered into by the RECIPIENT shall include an acknowledgement by the licensee that such License Agreement is subject to the INSTITUTE’s licenses, interests and other
rights under this Contract, [***]. In addition, all License Agreements shall include terms obligating the licensee to report to the RECIPIENT such information as is required for the RECIPIENT to fully comply with the terms of the Contract, including
without limitation the reporting obligations set forth in Attachment E to this Contract, and to allow RECIPIENT to make the grants specified in Sections D2.02. The RECIPIENT shall monitor the performance of its licensees and such licensees’
compliance with the terms of the License Agreements and shall take commercially reasonable actions to enforce the terms of all License Agreements. The RECIPIENT shall [***] report to the INSTITUTE any material breach of a License Agreement relating
to or affecting any of the material provisions of this Contract. [***] (K) In Part 3, Section D3.06, first sentence, after “commercialize or otherwise bring to practical application” insert -- [***] --; and in the last sentence,
after “is making efforts to commercialize at least one Commercial Product or Commercial Service” insert -- [***] --. Amended Section D3.06 is shown below: Section D3.06 Recipient Opt-Out.
In the event RECIPIENT determines, after diligently attempting to comply with the terms of Section D3.02, to cease its efforts, either directly or through a licensee, to commercialize or otherwise bring to practical application [***] the
Project Results, it will so notify the INSTITUTE in writing promptly thereafter. Such written notice must identify the Project Results and provide a reasonable explanation of the reasons for the RECIPIENT’s election. Upon receipt of such
notice, the INSTITUTE and RECIPIENT shall meet within [***] to review the Project Results and rationale for the RECIPIENT’s election. Provided that RECIPIENT’s determination to cease its efforts was not based on material safety concerns
related to the Project Results, the INSTITUTE and RECIPIENT shall engage in good faith negotiations regarding an alternative commercialization strategy and/or revenue sharing approach. The INSTITUTE and RECIPIENT may consider, among other options,
an award of equity in the RECIPIENT, expansion or modification of the Institute Funded Activity to cover other commercial products or commercial services being advanced by the RECIPIENT, or some combination thereof. Unless otherwise agreed, if the
INSTITUTE and RECIPIENT are unable to achieve an alternative strategy or agreement within [***] of the RECIPIENT’s initial notice of election, and provided that RECIPIENT’s determination to cease its efforts was not based on material
safety concerns related to the Project Results, the INSTITUTE shall have the right, but not the obligation, to exercise its rights in Section D5.01 in relation to the Project Results at the INSTITUTE’s expense. If the INSTITUTE elects to
exercise its rights under Section D5.01 in relation to the Project Results, the INSTITUTE shall notify the RECIPIENT in writing within [***] of INSTITUTE’s receipt of the RECIPIENT’s initial notice of election or [***] following a
declaration by one of the Parties that good faith negotiations have failed. In the event that the INSTITUTE exercises its option under this Section D3.06, the RECIPIENT shall cooperate with the INSTITUTE’s efforts and provide to INSTITUTE
sufficient information such as relevant feasibility studies, trial results, regulatory summaries, and pertinent schedules or deadlines in relation to the Project Results, in commercializing or otherwise bringing to practical application the
applicable Project Results at the INSTITUTE’s cost. For clarity, so long as the RECIPIENT is making efforts to commercialize at least one Commercial Product or Commercial Service [***], RECIPIENT shall have no obligation to provide the written
notice as described in this Section D3.06. (L) In Part 5, Section D5.01, delete this section in its entirety and replace with amended Section D5.01, as shown below: Section D5.01 RECIPIENT
Opt-Out. If the INSTITUTE elects to exercise its rights in relation to the Project Results under Section D3.06, the INSTITUTE shall have the right, but not the obligation, to pursue protection of the
applicable Institute-Funded IPR on its own behalf, including directing the filing, prosecution and maintenance of patents covering the applicable Institute-Funded Inventions and/or to commercialize or otherwise bring to practical application Project
Results covered by the applicable Institute-Funded IPR, at its own cost, either directly or through one or more licensees. If the INSTITUTE elects to exercise any such rights under this Section D5.01, it shall notify RECIPIENT in writing
pursuant to the notification requirements in Section D3.06 and RECIPIENT shall thereafter comply with the terms of Section D5.03 with regard to all applicable Institute-Funded IPR in which RECIPIENT has a right to assign or license.
(M) In Part 5, Section D5.02, replace each of three occurrences of “3.06” with -- D3.06 --. Amended Section D5.02 in relevant 

  
 40 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

			
	 Grant ID: DP160071
 Attachment F – CPRIT
Contact Change Notification
	  	PI/PD/CR: Jason Kim
		  	

  

 
part is shown below: Section D5.02 RECIPIENT Default. In the event that the INSTITUTE notifies RECIPIENT in writing of RECIPIENT’s failure to materially comply with its obligations
under Section D3.02, and RECIPIENT fails within [***] of such notice either: (a) to cure such failure, or in the event that such failure cannot be reasonably cured within such [***] period, to provide to INSTITUTE a plan to cure such
failure that INSTITUTE deems acceptable, (b) to provide written notice to the INSTITUTE that such failure was due to material safety concerns, or (c) to provide proper notice pursuant to Section D3.06, then without further action on
the part of the RECIPIENT or INSTITUTE, the RECIPIENT shall be deemed to have provided the INSTITUTE the complete, written notice of its cessation of efforts as described in Section D3.06, and the INSTITUTE shall be free to exercise its rights
under Section D3.06. (N) In Part 5, Section D5.03, delete this section in its entirety and replace with the following amended Section D5.03, as shown below: Section D5.03 RECIPIENT Cooperation upon Opt-Out or Default. In the event that the INSTITUTE exercises any of its rights under Section D5.01 or D5.02, the RECIPIENT shall: (1) subject to [***], transfer and assign, and does hereby assign, all of
its right, title and interest in and to the applicable Institute-Funded IPR to the INSTITUTE or the INSTITUTE’s designee, to the maximum extent allowed by law, including where relevant and necessary to facilitate the foregoing transfer,
requesting and diligently attempting to obtain any approvals required by law or otherwise in relation to such transfer, and subject to [***], hereby grants to the INSTITUTE a non-exclusive, royalty-free,
perpetual, fully transferable and sublicensable license under any Institute-Funded Technology and Necessary Additional IPR to Exploit the Institute-Funded IPR and Institute-Funded Technology for the development, manufacture and sale of Commercial
Products and Commercial Services and for all other purposes reasonably related thereto; (2) to the extent that RECIPIENT is unable to transfer all of its right, title and interest in and to the applicable Institute-Funded IPR to the INSTITUTE
as specified in Section D5.03(1), and subject to [***], RECIPIENT hereby grants to the INSTITUTE an exclusive, royalty-free, perpetual, fully transferable and sublicensable license under the applicable Institute-Funded IPR to Exploit the
applicable Institute-Funded IPR and Institute-Funded Technology for the development, manufacture and sale of Commercial Products and Commercial Services and for all other purposes reasonably related thereto, provided that the INSTITUTE may exercise
the foregoing rights only after exercising its right under Section D5.01; (3) cooperate with the INSTITUTE’s efforts, and at the INSTITUTE’s cost, in protecting applicable Institute-Funded IPR and Institute-Funded Technology, and in
commercializing or otherwise bringing to practical application the applicable Project Results (subject to [***]), including making relevant Recipient Personnel (to the extent still obligated to RECIPIENT), Contractors, Collaborators, records
(including without limitation, laboratory notebooks, electronic records and data), papers, information, samples, specimens and other materials related to the applicable Project Results reasonably available for such purposes and executing any
documents and taking any further action reasonably necessary to effectuate the intent of this Section D5.03; and (4) subject to applicable law, not take any action that would oppose or impede the INSTITUTE’s ability to protect the
applicable Institute-Funded IPR. If the INSTITUTE exercises its rights under Sections D5.01, the RECIPIENT shall have no further claim to or interest in the applicable Project Results, except as set forth in Section D2.01 of this
Attachment and shall not be entitled to any share of Revenue or any other compensation with respect to such Project Results, except to the minimum extent required by law, if any. To the extent that the INSTITUTE has exercised its rights under
Section D5.01 and RECIPIENT is unable to transfer all of its right, title and interest in and to the applicable Project Results to the INSTITUTE as specified in D5.03(1), then the INSTITUTE’s license set forth in D5.03(2) includes the
right, but not the obligation, and subject to [***] and [***] in and to [***], for the INSTITUTE at its cost to: (i) direct the filing, prosecution and maintenance of patents covering the applicable Project Results, and (ii) enforce all
applicable Institute-Funded IPR relevant to the Project Results against any infringement by a third party. Subject to the statutory duties of the Texas Attorney General, if any, RECIPIENT shall cooperate fully with the INSTITUTE in any action
brought by the INSTITUTE to enforce the Institute-Funded IPR in the applicable Project Results, at the INSTITUTE’s cost, including without limitation, joining the enforcement action in name as a party plaintiff after all required approvals are
obtained; provided that the INSTITUTE or its designee shall have full control over such enforcement action and shall receive and retain all monetary and other recoveries resulting from such enforcement actions, including any punitive damages.
(O) Part 6, Definitions, is amended to add new Sections (3), (5), (22) and (23); to amend Sections (11) - (14); and original sections have been renumbered to preserve consecutive numbering. Accordingly, Part 6, Definitions is deleted
in its entirety and replaced with the following amended Part 6, Definitions, as shown below: PART 6 DEFINITIONS Throughout this Attachment D, the following underlined terms shall have 

  
 41 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

			
	 Grant ID: DP160071
 Attachment F – CPRIT
Contact Change Notification
	  	PI/PD/CR: Jason Kim
		  	

  

 
the meanings given below. (1) Commercial Product means anything that is based on, utilizes or is developed from, or materially incorporates, the Project Results and that is capable of being
sold, licensed, transferred or conveyed to another party or is capable of otherwise being Exploited or disposed of, whether in exchange for consideration or not. (2) Commercial Service means any service performed that is based on, utilizes or
is developed from, or materially incorporates, the Project Results. For clarity, Commercial Service does not include non- commercial research and development performed by RECIPIENT or its Collaborators or
licensees. (3) CPRIT Project No. CC121020 Institute-Funded IPR means any and all Intellectual Property Rights in the following, resulting or arising from Institute-Funded Activity during the CPRIT Project No. CC121020 Contract term:
international patent applications [***] and [***], and related (a) proprietary and confidential information, including but not limited to data, trade secrets and know-how; (b) databases, compilations
and collections of data; (c) tools, methods and processes; and (d) works of authorship, excluding all scholarly works, but including, without limitation, computer programs, source code and executable code, whether embodied in software,
firmware or otherwise, documentation, files, records, data and mask works; and all applications of the foregoing in any form and embodied in any form, including but not limited to therapeutics, drugs, drug delivery systems, drug formulations,
devices, diagnostics, biomarkers, reagents and research tools. In no event shall Institute-Funded Technology include items that were conceived of, in existence, or owned/controlled by RECIPIENT prior to receipt of funds from the INSTITUTE to the
RECIPIENT for Project No. CC121020. (4) Cumulative Revenue means after the First Commercial Sale worldwide of a Commercial Product or Commercial Service, the sum of all Revenue in all years and calendar quarters up to the calendar quarter in
which the applicable revenue sharing percentage in Section D4.01 is being paid. (5) [***] means proprietary information, data, results, technologies, Inventions, materials, molecules and compositions owned, licensed or otherwise controlled by
RECIPIENT’s [***] or [***]. For the sake of clarity, “[***]” does not include CPRIT Project No. CC121020 Institute-Funded IPR. (6) Exclusive License means a License Agreement under which the specific rights granted to the
licensee with respect to the Project Results, including without limitation, scope of use and territorial rights, are granted on an exclusive basis. (7) Exclusivity means any exclusivities granted by the government in a country to provide an
entity with protection from competitors in the commercial market for a defined period of time, including but not limited to patent-based exclusivities (and any patent term extensions, supplementary protection certificates or patent term adjustments
thereof, and the like), and market-based “data” exclusivities (e.g., orphan drugs, new chemical entities, biologics, new formulations or combinations, and pediatric, and the like). For the avoidance of doubt, Exclusivity shall not mean any
protection gained solely from either trade secrets or trademarks. (8) Exploit or Exploitation means make, have made, use, sell, offer to sell, import, export, or otherwise commercialize, dispose of, practice, copy, distribute, create derivative
works of, publicly perform or publicly display. (9) First Commercial Sale means the first bona fide arm’s length Sale of a Commercial Product or Commercial Service to a Third Party by or on behalf of RECIPIENT or its licensees for monetary
value, for use or consumption by the end user of such Commercial Product or Commercial Service. For clarity, Sales of a Commercial Product or Commercial Service for registration samples, clinical trial purposes or compassionate use sales, named
patient use, test marketing, sampling and promotional uses, inter- company transfers to affiliates of RECIPIENT or its licensees, shall not constitute a First Commercial Sale. (10) Grant Award Proceeds means the sum of all monies paid by
INSTITUTE to RECIPIENT under the Contract. For clarity, Grant Award Proceeds will not be diminished by the amount of any funds repaid to INSTITUTE by RECIPIENT under Section 4.07 of the Contract. (11) Institute-Funded IPR means any and all
Intellectual Property Rights in and to Institute-Funded Technology pertaining to RECIPIENT Proprietary Technologies. In no event shall Institute-Funded IPR include [***]. Institute-Funded IPR also shall not include RECIPIENT Background IPR and/or
technology in existence and (a) owned/controlled by the RECIPIENT prior to the receipt of funds from the INSTITUTE under this Agreement; (b) arising from activities conducted independently of a CPRIT funded Project, including CPRIT Project
No. CC12010; or (c) acquired independently of the Project. (12) Institute-Funded Invention means an Invention conceived by or on behalf of RECIPIENT, including by Recipient Personnel, Contractor(s) and/or Collaborator(s) in the
performance of Institute-Funded Activity. (13) Institute-Funded Technology means any and all of the following resulting or arising, in whole or in part, from Institute-Funded Activity during the Contract term: (a) proprietary and
confidential information, including but not limited to data, trade secrets, materials and know-how; (b) databases, compilations and collections of data; (c) tools, methods and processes; and
(d) works of authorship, excluding all scholarly works, but including, without limitation, computer programs, source 

  
 42 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

			
	 Grant ID: DP160071
 Attachment F – CPRIT
Contact Change Notification
	  	PI/PD/CR: Jason Kim
		  	

  

 
code and executable code, whether embodied in software, firmware or otherwise, documentation, files, records, data and mask works; and all instantiations of the foregoing in any form and embodied
in any form, including but not limited to therapeutics, drugs, drug delivery systems, drug formulations, devices, diagnostics, biomarkers, reagents, methodologies and research tools. Institute-Funded Technology includes Institute-Funded Inventions.
Institute-Funded Technology shall not include subject matter that was conceived of, in existence, or owned/controlled by RECIPIENT prior to receipt of funds from the INSTITUTE under the Contract, [***], or any other subject matter arising from
activities conducted independently of the Project or acquired independently of the Project, such as but not limited to: (a) proprietary and confidential information, including but not limited to data, trade secrets, materials and know-how; (b) databases, compilations and collections of data; (c) tools, methods and processes; and (d) works of authorship, excluding all scholarly works, but including, without limitation, computer
programs, source code and executable code, whether embodied in software, firmware or otherwise, documentation, files, records, data and mask works; and all instantiations of the foregoing in any form and embodied in any form, including but not
limited to therapeutics, drugs, drug delivery systems, drug formulations, devices, diagnostics, biomarkers, reagents, methodologies and research tools. (14) Intellectual Property Rights or IPR means any and all of the following and all rights
in, arising out of, or associated therewith: (a) all United States and foreign patents and utility models and applications therefor, and all reissues, re-examinations, divisionals, renewals,
substitutions, extensions, provisionals, continuations and continuations-in part thereof, and equivalent or similar rights anywhere in the world in Inventions and other discoveries; (b) all trade secrets
and other rights in data, methods, results, discoveries, technology, know-how, compositions, materials and information; (c) all copyrights, copyright registrations and applications therefor, and all other
rights corresponding thereto throughout the world; (d) all mask works, mask work registrations and applications therefor, and any equivalent or similar rights in semiconductor masks, layouts, architectures or topology; and (e) any similar,
corresponding or equivalent rights to any of the foregoing anywhere in the world. (15) Invention means any idea, composition of matter, method, device, process or discovery that is conceived and/or reduced to practice, whether patentable or
not. (16) License Agreement means an agreement by which an owner of a Project Result grants any right to Exploit such Project Result to a Third Party in exchange for consideration. (17) Licensing Activities means the efforts of RECIPIENT
or its Collaborator to negotiate, execute or enforce a License Agreement. (18) Major Market Country means one or more of the following: [***]. (19) Necessary Additional IPR means any Intellectual Property Rights (a) solely owned by
RECIPIENT, and (b) identified by the Institute and agreed to in writing by RECIPIENT, [***], that are not Project Results but are necessary to Exploit the Project Results for the specific purposes set forth in the applicable Section of this
Attachment D. [***]. (20) Project Results means any and all Institute-Funded Technology and Institute-Funded IPR. (21) Revenue means the gross consideration, whether cash (for example, but not by way of limitation, any milestone fees,
license fees, sublicense fees, or assignment fees) or non-cash (for example, but not by way of limitation, securities, direct equity interest, indirect equity interest, trade or barter considerations, and the
like), received from Sales to a Third Party by or on behalf of the RECIPIENT and its licensees (including RECIPIENT’s affiliates and sublicensees of RECIPIENT’s licensee), net of: (a) trade or quantity discounts or rebates, credits,
allowances or refunds given for rejected or returned Commercial Products or Commercial Services, (b) any sales, value-added or other tax or governmental charge levied on the sale, transportation or delivery of a Commercial Product or Commercial
Service (but excluding any income tax owed by the RECIPIENT), and (c) any separately stated charges for freight, postage, shipping and insurance. The foregoing notwithstanding, any consideration: (i) received and used by RECIPIENT or its
licensees for the purpose of research or development of Commercial Products and Commercial Services, or (ii) received from Sales made solely in the performance of clinical trials designed to obtain regulatory approval for a Commercial Product
or Commercial Service, or (iii) received by RECIPIENT or its licensees from Sales made for compassionate use where no profit was obtained by RECIPIENT or its licensees shall not be included in this term. (22) RECIPIENT Background IPR means
all RECIPIENT IPR conceived of, in existence, or owned, licensed or otherwise controlled by RECIPIENT prior to receipt of funds from the INSTITUTE under the Contract. For the sake of clarity, “RECIPIENT Background IPR” does not include any
CPRIT Project No. CC121020 Institute-Funded IPR. (23) RECIPIENT Proprietary Technology means RECIPIENT’s proprietary information, technologies, materials, molecules, compositions and know-how
relating to its platform technology and Shiga IA-based engineered toxin bodies (ETBs), including its proprietary ETB directed to the CD38 molecular target, “[***]” as described in Exhibit A to the
Contract, and wherein [***]. (24) Revenue Term means 

  
 43 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

			
	 Grant ID: DP160071
 Attachment F – CPRIT
Contact Change Notification
	  	PI/PD/CR: Jason Kim
		  	

  

 
the period commencing on the date of the First Commercial Sale of a Commercial Product or Commercial Service and ending, on a
country-by-country basis, when there is not, or there no longer exists, any Exclusivity for the Commercial Product or Commercial Service in such country. If there is no
Exclusivity for a Commercial Product or Commercial Service in any Major Market Country, the Revenue Term shall mean the period commencing on the date of the First Commercial Sale of such Commercial Product or Commercial Service and [***]. (25) Sale
or Sales means any sale, license, lease, transfer, conveyance or other Exploitation or disposition of a Commercial Product or Commercial Service for which consideration from a first Third Party is received. For clarity, transfer or assignment of a
Commercial Product or Commercial Service in connection with a merger, consolidation, transfer or sale of all, or substantially all, of RECIPIENT’s business or assets, or change of control or similar transaction involving the RECIPIENT will not
constitute a Sale. (26) Third Party means a party other than (a) the RECIPIENT, (b) any affiliate or licensee of the RECIPIENT, either directly or through any sublicenses, or (c) an entity that enjoys any special course of
dealing with any of (a) or (b) above. Other terms may be defined elsewhere in this Attachment or in the Contract. 
 Description: Amendments to add two
definitions to the Base Contract, to reflect a potential timeline change in Aim 1 in Attachment A, and to make several changes to Attachment D. 
  

			
	RECIPIENT	 	INSTITUTE
		
	Molecular Templates, Inc.	 	Cancer Prevention & Research Institute of Texas
		
	ASO Name: Kim, Jason	 	CEO Name: Roberts, Wayne
		
	Submitted Date: 18 Sep 2018	 	Approved Date: 18 Sep 2018

  
 44 

Portions of this Exhibit, indicated by the mark “[***],” were omitted and have been filed separately with the 

Securities and Exchange Commission pursuant to the Registrant’s application requesting confidential treatment 

pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.Typenex Note Amendment  (M0381055.DOCX;1)

SECOND GLOBAL AMENDMENT

 

This Second Global Amendment (this “Second Amendment”) is entered into as of February 6, 2019 by and between St. George Investments LLC, a Utah limited liability company (“Lender”), and Global Arena Holding, Inc., a Delaware corporation (“Borrower”). Capitalized terms used in this Second Amendment without definition shall have the meanings given to them in the Notes (as defined below). 

 

A.Borrower previously issued to St. George a certain Convertible Promissory Note dated January 31, 2018 in the original principal amount of $167,000.00 (“St. George Note #1”) and a certain Convertible Promissory Note dated March 13, 2018 in the original principal amount of $815,000.00, of which only $225,000 of the Purchase Price has been funded to Borrower as of the date hereof (“St. George Note #2,” and together with St. George Note #1, the “Notes”). 

 

B.Lender and Borrower previously amended the Notes pursuant to that certain Global Amendment dated January 7, 2019 (the “First Amendment”). 

 

C.Lender and Borrower have agreed, subject to the terms, amendments, conditions and understandings expressed in this Second Amendment, to further amend the Notes as set forth herein. 

 

NOW, THEREFORE, for good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the parties agree as follows:

 

1.Recitals. Each of the parties hereto acknowledges and agrees that the recitals set forth above in this Second Amendment are true and accurate and are hereby incorporated into and made a part of this Second Amendment. 

 

2.No Conversion of Notes. Borrower and Lender hereby amend the Notes such that any Outstanding Balances or other amounts represented thereby shall no longer be subject to Conversion of any type, and Borrower hereby affirms its obligation to repay the Outstanding Balances or other amounts owing thereunder as otherwise set forth therein, as amended hereby and by the First Amendment.    

 

3.Payments in Cash; Amended Maturity Date. Borrower hereby agrees to repay the Notes in cash in full on or before the date that is nine (9) months from the date hereof, and any references to the manner of payment or the Maturity Date in the Notes are hereby amended accordingly.     

 

4.Event of Default.  If any Event of Default occurs under the Notes, Lender and Borrower hereby agree that this Second Amendment shall be considered null and void, and any amendments to the Notes effectuated hereunder shall be automatically cancelled with no further action required by any of the parties hereto.   

5.Representations and Warranties. In order to induce Lender to enter into this Second Amendment, Borrower, for itself, and for its affiliates, successors and assigns, hereby acknowledges, represents, warrants and agrees as follows: 

 

(a)Borrower has full power and authority to enter into this Second Amendment and to incur and perform all obligations and covenants contained herein, all of which have been duly authorized by all proper and necessary action. No consent, approval, filing or registration with or notice to any governmental authority is required as a condition to the validity of this Second Amendment or the performance of any of the obligations of Borrower hereunder. 

  

(b)There is no fact known to Borrower or which should be known to Borrower which Borrower has not disclosed to Lender on or prior to the date of this Second Amendment which would or could materially and adversely affect the understanding of Lender expressed in this Second Amendment or any representation, warranty, or recital contained in this Second Amendment. 

 

(c)Except as expressly set forth in this Second Amendment, Borrower acknowledges and agrees that neither the execution and delivery of this Second Amendment nor any of the terms, provisions, covenants, or agreements contained in this Second Amendment shall in any manner release, impair, lessen, modify, waive, or otherwise affect the liability and obligations of Borrower under the terms of the Notes. 

 

(d)Borrower has no defenses, affirmative or otherwise, rights of setoff, rights of recoupment, claims, counterclaims, actions or causes of action of any kind or nature whatsoever against Lender, directly or indirectly, arising out of, based upon, or in any manner connected with, the transactions contemplated hereby, whether known or unknown, which occurred, existed, was taken, permitted, or begun prior to the execution of this Second Amendment and occurred, existed, was taken, permitted or begun in accordance with, pursuant to, or by virtue of any of the terms or conditions of the Notes. To the extent any such defenses, affirmative or otherwise, rights of setoff, rights of recoupment, claims, counterclaims, actions or causes of action exist or existed, such defenses, rights, claims, counterclaims, actions and causes of action are hereby waived, discharged and released. Borrower hereby acknowledges and agrees that the execution of this Second Amendment by Lender shall not constitute an acknowledgment of or admission by Lender of the existence of any claims or of liability for any matter or precedent upon which any claim or liability may be asserted. 

 

(e)Borrower represents and warrants that as of the date hereof no Events of Default or other material breaches exist under the Notes or have occurred prior to the date hereof. 

 

6.Certain Acknowledgments. Each of the parties acknowledges and agrees that no property or cash consideration of any kind whatsoever has been or shall be given by Lender to Borrower in connection with any amendment to the Note granted herein.  

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7.Other Terms Unchanged. The Notes, as amended by the First Amendment and this Second Amendment, remain and continue in full force and effect, constitute legal, valid, and binding obligations of each of the parties, and are in all respects agreed to, ratified, and confirmed. Any reference to either of the Notes after the date of this Second Amendment is deemed to be a reference to such Note as amended by the First Amendment and this Second Amendment. If there is a conflict between the terms of this Second Amendment and any Note, the terms of this Second Amendment shall control. No forbearance or waiver may be implied by this Second Amendment. Borrower acknowledges that it is unconditionally obligated to pay the remaining balance of each Note and represents that such obligation is not subject to any deductions, defenses, rights of offset, or counterclaims of any kind. Except as expressly set forth herein, the execution, delivery, and performance of this Second Amendment shall not operate as a waiver of, or as an amendment to, any right, power, or remedy of Lender under the Notes, as in effect prior to the date hereof.  

 

8.No Reliance. Borrower acknowledges and agrees that neither Lender nor any of its officers, directors, members, managers, equity holders, representatives or agents has made any representations or warranties to Borrower or any of its agents, representatives, officers, directors, or employees except as expressly set forth in this Second Amendment and the Notes and, in making its decision to enter into the transactions contemplated by this Second Amendment, Borrower is not relying on any representation, warranty, covenant or promise of Lender or its officers, directors, members, managers, equity holders, agents or representatives other than as set forth in this Second Amendment.  

 

9.Counterparts. This Second Amendment may be executed in any number of counterparts, each of which shall be deemed an original, but all of which together shall constitute one instrument. The parties hereto confirm that any electronic copy of another party’s executed counterpart of this Second Amendment (or such party’s signature page thereof) will be deemed to be an executed original thereof.  

 

10.Further Assurances. Each party shall do and perform or cause to be done and performed, all such further acts and things, and shall execute and deliver all such other agreements, certificates, instruments and documents, as the other party may reasonably request in order to carry out the intent and accomplish the purposes of this Second Amendment and the consummation of the transactions contemplated hereby.  

 

[Remainder of page intentionally left blank]

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IN WITNESS WHEREOF, the undersigned have executed this Second Amendment as of the date set forth above.

 

 

BORROWER:

 

GLOBAL ARENA HOLDING, INC.

 

By: 
Name:  

Title:   

 

 

LENDER: 

 

ST. GEORGE INVESTMENTS LLC 

 

By: Fife Trading, Inc., its Manager 

 

 

By:  

             John M. Fife, President 

[Signature Page to Second Global Amendment]

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