Document:

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                                                                EXHIBIT 10.14(b)

[COMERICA LOGO]        MASTER REVOLVING NOTE
                       Variable Rate-Maturity Date-Optional Advances (Business
                       and Commercial Loans Only)

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AMOUNT         NOTE DATE           MATURITY DATE       TAX IDENTIFICATION NUMBER
$22,000,000    March 24, 2000      July 1, 2001        38-3383038
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ON THE MATURITY DATE, as stated above, for value received, the undersigned
promise(s) to pay to the order of Comerica Bank ("Bank"), at any office of the
Bank in the State of Michigan, Twenty Two Million Dollars (U.S.) (or that
portion of it advanced by the Bank and not repaid as later provided) with
interest until maturity, whether by acceleration or otherwise, or until Default,
as later defined, at a per annum rate equal to the Bank's prime rate from time
to time in effect minus one percent (1%) per annum so long as the aggregate
principal balance of this Note is greater than $2,000,000 and at a per annum
rate equal to the Bank's prime rate from time to time in effect so long as the
aggregate principal balance outstanding under this Note is $2,000,000 or less,
and after that at a rate equal to the rate of interest otherwise prevailing
under this Note plus three percent (3%) per annum (but in no event in excess of
the maximum rate permitted by law). The Bank's "prime rate" is that annual rate
of interest so designated by the Bank and which is changed by the Bank from time
to time. Interest rate changes will be effective for interest computation
purposes as and when the Bank's prime rate changes. Interest shall be calculated
on the basis of a 360-day year for actual number of days the principal is
outstanding. Accrued interest on this Note shall be payable on the first day of
each month commencing April 1, 2000, until the Maturity Date (set forth above)
when all amounts outstanding under this Note shall be due and payable in full.
If the frequency of interest payments is not otherwise specified, accrued
interest on this Note shall be payable monthly on the first day of each month.
If any payment of principal or interest under this Note shall be payable on a
day other than a day on which the Bank is open for business, this payment shall
be extended to the next succeeding business day and interest shall be payable at
the rate specified in this Note during this extension. A late payment charge
equal to five percent (5%) of each late payment may be charged on any payment
not received by the Bank within ten (10) calendar days after the payment due
date, but acceptance of payment of this charge shall not waive any Default under
this Note.

The principal amount payable under this Note shall be the sum of all advances
made by the Bank to or at the request of the undersigned, less principal
payments actually received in cash by the Bank. The books and records of the
Bank shall be the best evidence of the principal amount and the unpaid interest
amount owing at any time under this Note and shall be conclusive absent manifest
error. No interest shall accrue under this Note until the date of the first
advance made by the Bank; after that interest on all advances shall accrue and
be computed on the principal balance outstanding from time to time under this
Note until the same is paid in full.

This Note and any other indebtedness and liabilities of any kind of the
undersigned (or any of them) to the Bank, and any and all modifications,
renewals or extensions of it, whether joint or several, contingent or absolute,
now existing or later arising, and however evidenced (collectively
"Indebtedness"), are secured by and the Bank is granted a security interest in
all items deposited in any account of any of the undersigned with the Bank and
by all proceeds of these items (cash or otherwise), all account balances of any
of the undersigned from time to time with the Bank, by all property of any of
the undersigned from time to time in the possession of the Bank and by any other
collateral, rights and properties described in each and every deed of trust,
mortgage, security agreement, pledge, assignment and other security or
collateral agreement which has been, or will at any time(s) later be, executed
by any (or all) of the undersigned to or for the benefit of the Bank
(collectively "Collateral"). Notwithstanding the above, (i) to the extent that
any portion of the Indebtedness is a consumer loan, that portion shall not be
secured by any deed of trust, mortgage on or other security interest in any of
the undersigned's principal dwelling or in any of the undersigned's real
property which is not a purchase money security interest as to that portion,
unless expressly provided to the contrary in another place, or (ii) if the
undersigned (or any of them) has(have) given or give(s) Bank a deed of trust or
mortgage covering California real property, that deed of trust or mortgage shall
not secure this Note or any other indebtedness of the undersigned (or any of
them), unless expressly provided to the contrary in another place.

Upon the occurrence and at any time during the continuance of any "Event of
Default" under that certain Letter Agreement dated as of August 10, 1998, by and
between the undersigned and Bank, as the same may be amended from time to time,
Bank may, at its option and without prior notice to the undersigned, declare any
or all of the Indebtedness (whether under this Note or otherwise) to be
immediately due and payable (notwithstanding any provisions contained in the
evidence of it to the contrary), sell or liquidate all or any portion of the
Collateral, set off against the Indebtedness any amounts owing by the Bank to
the undersigned, charge interest at the default rate provided in the document
evidencing the relevant Indebtedness, and exercise any one or more of the rights
and remedies granted to the Bank by any agreement with the undersigned
(including, without limitation, said Letter Agreement) or given to it under
applicable law. All payments under this Note shall be in

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immediately available United States funds, without setoff or counterclaim.

If this Note is signed by two or more parties (whether by all as makers or by
one or more as an accommodation party or otherwise), the obligations and
undertakings under this Note shall be that of all and any two or more jointly
and also of each severally. This Note shall bind the undersigned, and the
undersigned's respective heirs, personal representatives, successors and
assigns. The undersigned waive(s) presentment, demand, protest, notice of
dishonor, notice of demand or intent to demand, notice of acceleration or intent
to accelerate, and all other notices and agree(s) that no extension or
indulgence to the undersigned (or any of them) or release, substitution or
nonenforcement of any security, or release or substitution of any of the
undersigned, any guarantor or any other party, whether with or without notice,
shall affect the obligations of any of the undersigned. The undersigned waive(s)
all defenses or right to discharge available under Section 3-605 of the Michigan
Uniform Commercial Code and waive(s) all other suretyship defenses or right to
discharge. The undersigned agree(s) that the Bank has the right to sell, assign,
or grant participations or any interest in, any or all of the Indebtedness, and
that, in connection with this right, but without limiting its ability to make
other disclosures to the full extent allowable, the Bank may disclose all
documents and information which the Bank now or later has relating to the
undersigned or the Indebtedness. The undersigned agree(s) that the Bank may
provide information relating to this Note or relating to the undersigned to the
Bank's parent, affiliates, subsidiaries and service providers.

The undersigned agree(s) to reimburse the holder or owner of this Note upon
demand for any and all costs and expenses (including without limit, court costs,
legal expenses and reasonable attorney fees, whether inside or outside counsel
is used, whether or not suit is instituted and, if suit is instituted, whether
at the trial court level, appellate level, in a bankruptcy, probate or
administrative proceeding or otherwise) incurred in collecting or attempting to
collect this Note or incurred in any other matter or proceeding relating to this
Note.

The undersigned acknowledge(s) and agree(s) that there are no contrary
agreements, oral or written, establishing a term of this Note and agree(s) that
the terms and conditions of this Note may not be amended, waived or modified
except in a writing signed by an officer of the Bank expressly stating that the
writing constitutes an amendment, waiver or modification of the terms of this
Note. As used in this Note, the word "undersigned" means, individually and
collectively, each maker, accommodation party, indorser and other party signing
this Note in a similar capacity. If any provision of this Note is unenforceable
in whole or part for any reason, the remaining provisions shall continue to be
effective. THIS NOTE IS MADE IN THE STATE OF MICHIGAN AND SHALL BE GOVERNED BY
AND CONSTRUED IN ACCORDANCE WITH THE INTERNAL LAWS OF THE STATE OF MICHIGAN,
WITHOUT REGARD TO CONFLICT OF LAWS PRINCIPLE.

THE MAXIMUM INTEREST RATE SHALL NOT EXCEED 25% PER ANNUM, OR THE HIGHEST
APPLICABLE USURY CEILING, WHICHEVER IS LESS.

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THE UNDERSIGNED AND THE BANK ACKNOWLEDGE THAT THE RIGHT TO TRIAL BY JURY IS A
CONSTITUTIONAL ONE, BUT THAT IT MAY BE WAIVED. EACH PARTY, AFTER CONSULTING (OR
HAVING HAD THE OPPORTUNITY TO CONSULT) WITH COUNSEL OF THEIR CHOICE, KNOWINGLY
AND VOLUNTARILY, AND FOR THEIR MUTUAL BENEFIT, WAIVES ANY RIGHT TO TRIAL BY JURY
IN THE EVENT OF LITIGATION REGARDING THE PERFORMANCE OR ENFORCEMENT OF, OR IN
ANY WAY RELATED TO, THIS NOTE OR THE INDEBTEDNESS.

<TABLE>
<S><C>

  GENOMIC SOLUTIONS, INC.                 By: Jeffrey S. Williams      Its: President and CEO
 OBLIGOR NAME TYPED/PRINTED                   -------------------
                                          SIGNATURE OF                 TITLE (if applicable)

                                          By: Steven Richvalsky       Its:  Exec VP and CFO
                                              -------------------
                                          SIGNATURE OF                 TITLE (if applicable)

                                          By:                          Its:
                                              -------------------           -------------------
                                          SIGNATURE OF                 TITLE  (if applicable)

                                          By:                          Its:
                                              -------------------           -------------------
                                          SIGNATURE OF                 TITLE  (if applicable)

4355 Varsity Drive, Suite E                                 Ann Arbor                 Michigan              48108
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STREET ADDRESS                                                CITY                      STATE             ZIP CODE

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     FOR BANK USE ONLY                                                                       CCAR #
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LOAN OFFICER INITIALS         LOAN GROUP NAME       OBLIGOR NAME

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LOAN OFFICER ID. NO.          LOAN GROUP NO.        OBLIGOR NO.               NOTE NO.                    AMOUNT

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</TABLE>

                                       3<PAGE>   1

                                                                EXHIBIT 10.14(c)

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             Trading permitted?                    yes          X      no
                                        --------           ---------
             Withdrawals permitted?                yes          X      no
                                        --------           ---------

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                               SECURITY AGREEMENT
                              (Securities Account)

As of March 24, 2000, for value received, the undersigned ("Debtor") grants to
Comerica Bank ("Bank"), a Michigan banking corporation, a continuing security
interest in the Collateral (as defined below) to secure payment when due,
whether by stated maturity, demand acceleration or otherwise, of all existing
and future indebtedness ("Indebtedness") to the Bank of         N/A
("Borrower") and/or Debtor. Indebtedness includes without limit any and all
obligations or liabilities of the Borrower and/or Debtor to the Bank, whether
absolute or contingent, direct or indirect, voluntary or involuntary, liquidated
or unliquidated, joint or several, known or unknown; any and all obligations or
liabilities for which the Borrower and/or Debtor would otherwise be liable to
the Bank were it not for the invalidity or unenforceability of them by reason of
any bankruptcy, insolvency or other law, or for any other reason; any and all
amendments, modifications, renewals and/or extensions of any of the above; all
costs incurred by Bank in establishing, determining, continuing, or defending
the validity or priority of its security interest, or in pursuing its rights and
remedies under this Agreement or under any other agreement between Bank and
Borrower and/or Debtor or in connection with any proceeding involving Bank as a
result of any financial accommodation to Borrower and/or Debtor; and all other
costs of collecting Indebtedness, including without limit attorney fees. Debtor
agrees to pay Bank all such costs incurred by the Bank, immediately upon demand,
and until paid all costs shall bear interest at the highest per annum rate
applicable to any of the Indebtedness, but not in excess of the maximum rate
permitted by law. Any reference in this Agreement to attorney fees shall be
deemed a reference to reasonable fees, costs, and expenses of both in-house and
outside counsel and paralegals, whether or not a suit or action is instituted,
and to court costs if a suit or action is instituted, and whether attorney fees
or court costs are incurred at the trial court level, on appeal, in a
bankruptcy, administrative or probate proceeding or otherwise.

1.       COLLATERAL shall mean all of the following property Debtor now or later
         owns or has an interest in, wherever located:

         (a)      all of Debtor's right, title and interest (including without
                  limitation, security entitlement) in securities account no.
                  183000329 ("the Account') maintained at Comerica Securities
                  ("Securities Intermediary") and all cash, securities,
                  investment property or financial assets now or hereafter
                  deposited or maintained in the Account

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                  or credited to the Account, and any and all securities
                  accounts in substitution or replacement thereof;

         (b)      all goods, instruments, documents, policies and certificates
                  of insurance, deposits, money, investment property or other
                  property (except real property which is not a fixture) which
                  are now or later in possession or control of Bank, or as to
                  which Bank now or later controls possession by documents or
                  otherwise, and

         (c)      all additions, attachments, accessions, parts, replacements,
                  substitutions, renewals, interest, dividends, distributions,
                  rights of any kind (including but not limited to stock splits,
                  stock rights, voting and preferential rights), products, and
                  proceeds of or pertaining to the above including, without
                  limit, cash or other property which were proceeds and are
                  recovered by a bankruptcy trustee or otherwise as a
                  preferential transfer by Debtor.

2. WARRANTIES, COVENANTS AND AGREEMENTS. Debtor warrants, covenants and agrees
as follows:

     1.1  Debtor shall furnish to Bank, in form and at intervals as Bank may
          request, any information Bank may reasonably request and allow Bank to
          examine, inspect, and copy any of Debtor's books and records. Debtor
          shall, at the request of Bank, mark its records and the Collateral to
          clearly indicate the security interest of Bank under this Agreement.

     1.2  At the time any Collateral becomes, or is represented to be, subject
          to a security interest in favor of Bank, Debtor shall be deemed to
          have warranted that (a) Debtor is the lawful owner of the Collateral
          and has the right and authority to subject it to a security interest
          granted to Bank or as permitted in the Account Control Agreement (as
          defined below); (b) none of the Collateral is subject to any security
          interest other than that in favor of Bank and there are no financing
          statements on file, other than in favor of Bank or as permitted in the
          Account Control Agreement; and (c) Debtor acquired its rights in the
          Collateral in the ordinary course of its business.

     1.3  Debtor will keep the Collateral free at all times from all claims,
          liens, security interests and encumbrances other than those in favor
          of Bank or as permitted in the Account Control Agreement. Debtor will
          not, without the prior written consent of Bank, sell, transfer or
          lease, or permit to be sold, transferred or leased, any or all of the
          Collateral, except to the extent permitted in the Account Control
          Agreement. Bank or its representatives may at all reasonable times
          inspect the Collateral and may enter upon all premises where the
          Collateral is kept or might be located.

     1.4  Debtor will do all acts and will execute or cause to be executed all
          writings requested by Bank to establish, maintain and continue a
          perfected and first security interest of

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          Bank in the Collateral. Debtor agrees that Bank has no obligation to
          acquire or perfect any lien on or security interest in any asset(s),
          whether realty or personalty, to secure payment of the Indebtedness,
          and Debtor is not relying upon assets in which the Bank may have a
          lien or security interest for payment of the Indebtedness.

     1.5  Debtor will pay within the time that they can be paid without interest
          or penalty all taxes, assessments and similar charges which at any
          time are or may become a lien, charge, or encumbrance upon any
          Collateral, except to the extent contested in good faith and bonded in
          a manner satisfactory to Bank. If Debtor fails to pay any of these
          taxes, assessments, or other charges in the time provided above, Bank
          has the option (but not the obligation) to do so and Debtor agrees to
          repay all amounts so expended by Bank immediately upon demand,
          together with interest at the highest lawful default rate which could
          be charged by Bank on any Indebtedness.

     1.6  Debtor will keep the Collateral in good condition and will protect it
          from loss, damage, or deterioration from any cause. Debtor has and
          will maintain at all times (a) with respect to the Collateral,
          insurance under an "all risk" policy against fire and other risks
          customarily insured against, and (b) public liability insurance and
          other insurance as may be required by law or reasonably required by
          Bank, all of which insurance shall be in amount, form and content, and
          written by companies as may be satisfactory to Bank, containing a
          lender's loss payable endorsement acceptable to Bank. Debtor will
          deliver to Bank immediately upon demand evidence satisfactory to Bank
          that the required insurance has been procured. If Debtor fails to
          maintain satisfactory insurance, Bank has the option (but not the
          obligation) to do so and Debtor agrees to repay all amounts so
          expended by Bank immediately upon demand, together with interest at
          the highest lawful default rate which could be charged by Bank on any
          Indebtedness.

     1.7  Debtor at all times shall be in strict compliance with all applicable
          laws, including without limit any laws, ordinances, directives,
          orders, statutes, or regulations an object of which is to regulate or
          improve health, safety, or the environment ("Environmental Laws").

     1.8  If at any time the value of the Collateral is less than $20,000,000,
          as determined from time to time by Bank, Debtor must provide or cause
          to be provided to Bank additional collateral in the form of cash or
          other property acceptable to Bank and with a value, as determined by
          Bank, that when added to the Collateral will cause the Collateral to
          be valued at at least $20,000,000.

     1.9  If Bank, acting in its sole discretion, redelivers Collateral to
          Debtor or Debtor's designee for the purpose of (a) the ultimate sale
          or exchange thereof; or (b) presentation, collection, renewal, or
          registration of transfer thereof; or (c) loading, unloading, storing,
          shipping, transshipping, manufacturing, processing or otherwise

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          dealing with it preliminary to sale or exchange; such redelivery shall
          be in trust for the benefit of Bank and shall not constitute a release
          of Bank's security interest in it or in the proceeds or products of it
          unless Bank specifically so agrees in writing. If Debtor requests any
          such redelivery, Debtor will deliver with such request a duly executed
          financing statement in form and substance satisfactory to Bank. Any
          proceeds of Collateral coming into Debtor's possession as a result of
          any such redelivery shall be held in trust for Bank and immediately
          delivered to Bank for application on the Indebtedness. Bank may (in
          its sole discretion) deliver any or all of the Collateral to Debtor,
          and such delivery by Bank shall discharge Bank from all liability or
          responsibility for such Collateral. Bank, at its option, may require
          delivery of any Collateral to Bank at any time with such endorsements
          or assignments of the Collateral as Bank may request.

     1.10 At any time and without notice, Bank may (a) cause any or all of the
          Collateral to be transferred to its name or to the name of its
          nominees; (b) receive or collect by legal proceedings or otherwise all
          dividends, interest, principal payments and other sums and all other
          distributions at any time payable or receivable on account of the
          Collateral, and hold the same as Collateral, or apply the same to the
          Indebtedness, the manner and distribution of the application to be in
          the sole discretion of Bank; (c) enter into any extension,
          subordination, reorganization, deposit, merger or consolidation
          agreement or any other agreement relating to or affecting the
          Collateral, and deposit or surrender control of the Collateral, and
          accept other property in exchange for the Collateral and hold or apply
          the property or money so received pursuant to this Agreement.

     1.11 Bank may assign any of the Indebtedness and deliver any or all of the
          Collateral to its assignee, who then shall have with respect to
          Collateral so delivered all the rights and powers of Bank under this
          Agreement, and after that Bank shall be fully discharged from all
          liability and responsibility with respect to Collateral so delivered.

     1.12 Debtor delivers this Agreement based solely on Debtor's independent
          investigation of (or decision not to investigate) the financial
          condition of Borrower and is not relying on any information furnished
          by Bank. Debtor assumes full responsibility for obtaining any further
          information concerning the Borrower's financial condition, the status
          of the Indebtedness or any other matter which the undersigned may deem
          necessary or appropriate now or later. Debtor waives any duty on the
          part of Bank, and agrees that Debtor is not relying upon nor expecting
          Bank to disclose to Debtor any fact now or later known by Bank,
          whether relating to the operations or condition of Borrower, the
          existence, liabilities or financial condition of any guarantor of the
          Indebtedness, the occurrence of any default with respect to the
          Indebtedness, or otherwise, notwithstanding any effect such fact may
          have upon Debtor's risk or Debtor's rights against Borrower. Debtor
          knowingly accepts the full range of risk encompassed in this
          Agreement, which risk includes without limit the possibility that

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          Borrower may incur Indebtedness to Bank after the financial condition
          of Borrower, or Borrower's ability to pay debts as they mature, has
          deteriorated.

     1.13 Debtor shall defend, indemnify and hold harmless Bank, its employees,
          agents, shareholders, affiliates, officers, and directors from and
          against any and all claims, damages, fines, expenses, liabilities or
          causes of action of whatever kind, including without limit consultant
          fees, legal expenses, and attorney fees, suffered by any of them as a
          direct or indirect result of any actual or asserted violation of any
          law, including, without limit, Environmental Laws, or of any
          remediation relating to any property required by any law, including
          without limit Environmental Laws.

3.   COLLECTION OF PROCEEDS. Debtor agrees to collect and enforce payment of all
     Collateral until Bank shall direct Debtor to the contrary. Immediately upon
     notice to Debtor by Bank and at all times after that, Debtor agrees to
     fully and promptly cooperate and assist Bank in the collection and
     enforcement of all Collateral and to hold in trust for Bank all payments
     received in connection with Collateral and from the sale, lease or other
     disposition of any Collateral, all rights by way of suretyship or guaranty
     and all rights in the nature of a lien or security interest which Debtor
     now or later has regarding Collateral. Immediately upon and after such
     notice, Debtor agrees to (a) endorse to Bank and immediately deliver to
     Bank all payments received on Collateral or from the sale, lease or other
     disposition of any Collateral or arising from any other rights or interests
     of Debtor in the Collateral, in the form received by Debtor without
     commingling with any other funds, and (b) immediately deliver to Bank all
     property in Debtor's possession or later coming into Debtor's possession
     through enforcement of Debtor's rights or interests in the Collateral.
     Debtor irrevocably authorizes Bank or any Bank employee or agent to endorse
     the name of Debtor upon any checks or other items which are received in
     payment for any Collateral, and to do any and all things necessary in order
     to reduce these items to money. Bank shall have no duty as to the
     collection or protection of Collateral or the proceeds of it, nor as to the
     preservation of any related rights, beyond the use of reasonable care in
     the custody and preservation of Collateral in the possession of Bank.
     Debtor agrees to take all steps necessary to preserve rights against prior
     parties with respect to the Collateral. Nothing in this Section 3 shall be
     deemed a consent by Bank to any sale, lease or other disposition of any
     Collateral.

4.   DEFAULTS, ENFORCEMENT AND APPLICATION OF PROCEEDS.

     1.14 Upon the occurrence and at any time during the continuance of any
          Event of Default under that certain Letter Agreement dated as of
          August 10, 1998 by and between the Debtor and Bank, as the same may be
          amended from time to time (each an "Event of Default"), Debtor shall
          be in default under this Agreement.

                                       5
<PAGE>   6

     1.15 Upon the occurrence of any Event of Default, Bank may at its
          discretion and without prior notice to Debtor declare any or all of
          the Indebtedness to be immediately due and payable and Bank shall have
          and may exercise any one or more of the following rights and remedies:

          (a)  Exercise all the rights and remedies upon default, in foreclosure
               and otherwise, available to secured parties under the provisions
               of the Uniform Commercial Code and other applicable law;

          (b)  Institute legal proceedings to foreclose upon the lien and
               security interest granted by this Agreement, to recover judgment
               for all amounts then due and owing as Indebtedness, and to
               collect the same out of any Collateral or the proceeds of any
               sale of it;

          (c)  Institute legal proceedings for the sale, under the judgment or
               decree of any court of competent jurisdiction, of any or all
               Collateral; and/or

          (d)  Personally or by agents, attorneys, or appointment of a receiver,
               enter upon any premises where Collateral may then be located, and
               take possession of all or any of it and/or render it unusable;
               and without being responsible for loss or damage to such
               Collateral, hold, operate, sell, lease, or dispose of all or any
               Collateral at one or more public or private sales, leasings or
               other dispositions, at places and times and on terms and
               conditions as Bank may deem fit, without any previous demand or
               advertisement; and except as provided in this Agreement, all
               notice of sale, lease or other disposition, and advertisement,
               and other notice or demand, any right or equity of redemption,
               and any obligation of a prospective purchaser or lessee to
               inquire as to the power and authority of Bank to sell, lease, or
               otherwise dispose of the Collateral or as to the application by
               Bank of the proceeds of sale or otherwise, which would otherwise
               be required by, or available to Debtor under, applicable law are
               expressly waived by Debtor to the fullest extent permitted.

               At any sale pursuant to this Section 4.2, whether under the power
               of sale, by virtue of judicial proceedings or otherwise, it shall
               not be necessary for Bank or a public officer under order of a
               court to have present physical or constructive possession of
               Collateral to be sold. The recitals contained in any conveyances
               and receipts made and given by Bank or the public officer to any
               purchaser at any sale made pursuant to this Agreement shall, to
               the extent permitted by applicable law, conclusively establish
               the truth and accuracy of the matters stated (including, without
               limit, as to the amounts of the principal of and interest on the
               Indebtedness, the accrual and nonpayment of it and advertisement
               and conduct of the sale); and all prerequisites to the sale shall

                                       6

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               be presumed to have been satisfied and performed. Upon any sale
               of any Collateral, the receipt of the officer making the sale
               under judicial proceedings or of Bank shall be sufficient
               discharge to the purchaser for the purchase money, and the
               purchaser shall not be obligated to see to the application of the
               money. Any sale of any Collateral under this Agreement shall be a
               perpetual bar against Debtor with respect to that Collateral.

          4.3  Debtor shall at the request of Bank, notify the account debtors
               or obligors of Bank's security interest in any Collateral and
               direct payment of it to Bank. Bank may, itself, upon the
               occurrence of any Event of Default so notify and direct any
               account debtor or obligor.

          4.4  The proceeds of any sale or other disposition of Collateral
               authorized by this Agreement shall be applied by Bank first upon
               all expenses authorized by the Uniform Commercial Code and all
               reasonable attorney fees and legal expenses incurred by Bank; the
               balance of the proceeds of the sale or other disposition shall be
               applied in the payment of the Indebtedness, first to interest,
               then to principal, then to remaining Indebtedness and the
               surplus, if any, shall be paid over to Debtor or to such other
               person(s) as may be entitled to it under applicable law. Debtor
               shall remain liable for any deficiency, which it shall pay to
               Bank immediately upon demand.

          4.5  Nothing in this Agreement is intended, nor shall it be construed,
               to preclude Bank from pursuing any other remedy provided by law
               for the collection of the Indebtedness or for the recovery of any
               other sum to which Bank may be entitled for the breach of this
               Agreement by Debtor. Nothing in this Agreement shall reduce or
               release in any way any rights or security interests of Bank
               contained in any existing agreement between Borrower, Debtor, or
               any Guarantor and Bank.

          4.6  No waiver of default or consent to any act by Debtor shall be
               effective unless in writing and signed by an authorized officer
               of Bank. No waiver of any default or forbearance on the part of
               Bank in enforcing any of its rights under this Agreement shall
               operate as a waiver of any other default or of the same default
               on a future occasion or of any rights.

          4.7  Debtor irrevocably appoints Bank or any agent of Bank (which
               appointment is coupled with an interest) the true and lawful
               attorney of Debtor (with full power of substitution) in the name,
               place and stead of, and at the expense of, Debtor:

               (a)  to demand, receive, sue for, and give receipts or
                    acquittances for any moneys due or to become due with
                    respect to any Collateral and to endorse any item
                    representing any payment on or proceeds of the Collateral;

                                       7

<PAGE>   8

               (b)  to execute and file in the name of and on behalf of Debtor
                    all financing statements or other filings deemed necessary
                    or desirable by Bank to evidence, perfect, or continue the
                    security interests granted in this Agreement; and

               (c)  to do and perform any act on behalf of Debtor permitted or
                    required under this Agreement.

          4.8  Upon the occurrence of an Event of Default, Debtor also agrees,
               upon request of Bank, to assemble the Collateral and make it
               available to Bank at any place designated by Bank which is
               reasonably convenient to Bank and Debtor.

5.        MISCELLANEOUS.

          5.1  Until Bank is advised in writing by Debtor to the contrary, all
               notices, requests and demands required under this Agreement or by
               law shall be given to, or made upon, Debtor at the first address
               indicated in Section 5.15 below.

          5.2  Debtor will give Bank not less than 90 days prior written notice
               of all contemplated changes in Debtor's name, chief executive
               office location, and/or location of any Collateral, but the
               giving of this notice shall not cure any Event of Default caused
               by this change.

          5.3  Bank assumes no duty of performance or other responsibility under
               any contracts contained within the Collateral.

          5.4  Bank has the right to sell, assign, transfer, negotiate or grant
               participations or any interest in, any or all of the Indebtedness
               and any related obligations, including without limit this
               Agreement. In connection with the above, but without limiting its
               ability to make other disclosures to the full extent allowable,
               Bank may disclose all documents and information which Bank now or
               later has relating to Debtor, the Indebtedness or this Agreement,
               however obtained. Debtor further agrees that Bank may provide
               information relating to this Agreement or relating to Debtor to
               the Bank's parent, affiliates, subsidiaries, and service
               providers.

          5.5  In addition to Bank's other rights, any indebtedness owing from
               Bank to Debtor can be set off and applied by Bank on any
               Indebtedness at any time(s) either before or after maturity or
               demand without notice to anyone.

          5.6  Debtor waives any right to require the Bank to: (a) proceed
               against any person or property; (b) give notice of the terms,
               time and place of any public or private sale of personal property
               security held from Borrower or any other person, or otherwise
               comply with the provisions of Section 9-504 of the Uniform
               Commercial Code; or

                                       8

<PAGE>   9

               (c) pursue any other remedy in the Bank's power. Debtor waives
               notice of acceptance of this Agreement and presentment, demand,
               protest, notice of protest, dishonor, notice of dishonor, notice
               of default, notice of intent to accelerate or demand payment of
               any Indebtedness, any and all other notices to which the
               undersigned might otherwise be entitled, and diligence in
               collecting any Indebtedness, and agree(s) that the Bank may, once
               or any number of times, modify the terms of any Indebtedness,
               compromise, extend, increase, accelerate, renew or forbear to
               enforce payment of any or all Indebtedness, or permit Borrower to
               incur additional Indebtedness, all without notice to Debtor and
               without affecting in any manner the unconditional obligation of
               Debtor under this Agreement. Debtor unconditionally and
               irrevocably waives each and every defense and setoff of any
               nature which, under principles of guaranty or otherwise, would
               operate to impair or diminish in any way the obligation of Debtor
               under this Agreement, and acknowledges that such waiver is by
               this reference incorporated into each security agreement,
               collateral assignment, pledge and/or other document from Debtor
               now or later securing the Indebtedness, and acknowledges that as
               of the date of this Agreement no such defense or setoff exists.

          5.7  Debtor waives any and all rights (whether by subrogation,
               indemnity, reimbursement, or otherwise) to recover from Borrower
               any amounts paid or the value of any Collateral given by Debtor
               pursuant to this Agreement.

          5.8  In the event that applicable law shall obligate Bank to give
               prior notice to Debtor of any action to be taken under this
               Agreement, Debtor agrees that a written notice given to Debtor at
               least five days before the date of the act shall be reasonable
               notice of the act and, specifically, reasonable notification of
               the time and place of any public sale or of the time after which
               any private sale, lease, or other disposition is to be made,
               unless a shorter notice period is reasonable under the
               circumstances. A notice shall be deemed to be given under this
               Agreement when delivered to Debtor or when placed in an envelope
               addressed to Debtor and deposited, with postage prepaid, in a
               post office or official depository under the exclusive care and
               custody of the United States Postal Service or delivered to an
               overnight courier. The mailing shall be by overnight courier,
               certified, or first class mail.

          5.9  Notwithstanding any prior revocation, termination, surrender, or
               discharge of this Agreement in whole or in part, the
               effectiveness of this Agreement shall automatically continue or
               be reinstated in the event that any payment received or credit
               given by Bank in respect of the Indebtedness is returned,
               disgorged, or rescinded under any applicable law, including,
               without limitation, bankruptcy or insolvency laws, in which case
               this Agreement, shall be enforceable against Debtor as if the
               returned, disgorged, or rescinded payment or credit had not been
               received or given by Bank, and whether or not Bank relied upon
               this payment or credit or changed its position as a consequence
               of it. In the event of continuation or

                                       9
<PAGE>   10

               reinstatement of this Agreement, Debtor agrees upon demand by
               Bank to execute and deliver to Bank those documents which Bank
               determines are appropriate to further evidence (in the public
               records or otherwise) this continuation or reinstatement,
               although the failure of Debtor to do so shall not affect in any
               way the reinstatement or continuation.

          5.10 This Agreement and all the rights and remedies of Bank under this
               Agreement shall inure to the benefit of Bank's successors and
               assigns and to any other holder who derives from Bank title to or
               an interest in the Indebtedness or any portion of it, and shall
               bind Debtor and the heirs, legal representatives, successors, and
               assigns of Debtor. Nothing in this Section 5.10 is deemed a
               consent by Bank to any assignment by Debtor.

          5.11 If there is more than one Debtor, all undertakings, warranties
               and covenants made by Debtor and all rights, powers and
               authorities given to or conferred upon Bank are made or given
               jointly and severally.

          5.12 Except as otherwise provided in this Agreement, all terms in this
               Agreement have the meanings assigned to them in Article 9 (or,
               absent definition in Article 9, in any other Article) of the
               Uniform Commercial Code, as of the date of this Agreement.
               "Uniform Commercial Code" means Act No. 174 of the Michigan
               Public Acts of 1962, as amended.

          5.13 No single or partial exercise, or delay in the exercise, of any
               right or power under this Agreement, shall preclude other or
               further exercise of the rights and powers under this Agreement.
               The unenforceability of any provision of this Agreement shall not
               affect the enforceability of the remainder of this Agreement.
               This Agreement constitutes the entire agreement of Debtor and
               Bank with respect to the subject matter of this Agreement. No
               amendment or modification of this Agreement shall be effective
               unless the same shall be in writing and signed by Debtor and an
               authorized officer of Bank. This Agreement shall be governed by
               and construed in accordance with the internal laws of the State
               of Michigan, without regard to conflict of laws principles.

          5.14 To the extent that any of the Indebtedness is payable upon
               demand, nothing contained in this Agreement shall modify the
               terms and conditions of that Indebtedness nor shall anything
               contained in this Agreement prevent Bank from making demand,
               without notice and with or without reason, for immediate payment
               of any or all of that Indebtedness at any time(s), whether or not
               an Event of Default has occurred.

          5.15 Debtor's chief executive office is located and shall be
               maintained at :

                4355 Varsity Drive, Suite E, Ann Arbor, MI 48108

                                       10

<PAGE>   11

         If Collateral is located at other than the chief executive office, such
         Collateral is located and shall be maintained at:

         -----------------------------------------------------------------------

         -----------------------------------------------------------------------

         Collateral shall be maintained only at the locations identified in this
         Section 5.15.

         5.16     A carbon, photographic or other reproduction of this Agreement
                  shall be sufficient as a financing statement under the Uniform
                  Commercial Code and may be filed by Bank in any filing office.

         5.17     This Agreement shall be terminated only by the filing of a
                  termination statement in accordance with the applicable
                  provisions of the Uniform Commercial Code, but the obligations
                  contained in Section 2m of this Agreement shall survive
                  termination.

6.       DEBTOR AND BANK ACKNOWLEDGE THAT THE RIGHT TO TRIAL BY JURY IS A
         CONSTITUTIONAL ONE, BUT THAT IT MAY BE WAIVED. EACH PARTY, AFTER
         CONSULTING (OR HAVING HAD THE OPPORTUNITY TO CONSULT) WITH COUNSEL OF
         THEIR CHOICE, KNOWINGLY AND VOLUNTARILY, AND FOR THEIR MUTUAL BENEFIT
         WAIVES ANY RIGHT TO TRIAL BY JURY IN THE EVENT OF LITIGATION REGARDING
         THE PERFORMANCE OR ENFORCEMENT OF, OR IN ANY WAY RELATED TO, THIS
         AGREEMENT OR THE INDEBTEDNESS.

7.       SPECIAL PROVISIONS APPLICABLE TO THIS AGREEMENT.

         (a)      This Agreement is subject to the terms of that certain Account
                  Control Agreement dated March 24, 2000 among the undersigned,
                  Bank and Securities Intermediary (as may be amended, "Account
                  Control Agreement"). In the event of any conflict between the
                  terms of this Agreement and the terms of the Account Control
                  Agreement, the terms of the Account Control Agreement shall
                  govern and control.

         (b)      In the exercise of its remedies set forth in Section 4.2
                  above, or as otherwise provided by law, upon the occurrence of
                  an Event of Default Bank may, at its discretion and without
                  prior notice to or consent of the undersigned, issue
                  entitlement orders to Securities Intermediary with respect to
                  all or any part of the Collateral.

         (c)      Debtor shall not withdraw or transfer or authorize Securities
                  Intermediary or any other person or entity to withdraw or
                  transfer any assets from the Account without the prior written
                  consent of Bank.

                                       11
<PAGE>   12

         (d)      Debtor shall not sell or trade and shall not authorize or
                  permit the Securities Intermediary or any other person or
                  entity to sell or trade any assets in the Account without the
                  prior written consent of Bank.

         (e)      Debtor shall reimburse Bank for the payment of, on demand, all
                  costs and expenses, including without limitation, reasonable
                  attorneys' fees, incurred by Bank under the terms of the
                  Account Control Agreement, in the amendment, waiver or
                  enforcement of this Agreement or the Account Control
                  Agreement, in the protection of its rights under this
                  Agreement or the Account Control Agreement or any action or
                  proceeding relating to this Agreement or the Account Control
                  Agreement.

                                     DEBTOR:

                                     GENOMIC SOLUTIONS, INC.

                                     By:      Jeffrey S. Williams
                                              SIGNATURE OF

                                     Its:     President and CEO
                                              TITLE (If applicable)

                                       12

<PAGE>   13

                            ACCOUNT CONTROL AGREEMENT

         This Agreement dated as of March 24, 2000 among Comerica Bank ("Secured
Party"), Genomic Solutions, Inc. ("Pledgor"), and Comerica Securities
("Securities Intermediary"):

                                    RECITALS:

         A. Securities Intermediary has established a securities account #
183000329 in the name of Pledgor ("Account") pursuant to a customer agreement
dated March 30, 2000 between Securities Intermediary and Pledgor ("Customer
Agreement").

         B. Pledgor granted Secured Party a security interest in the Account
pursuant to a Security Agreement dated March 24, 2000.

         The parties agree as follows:

         1. THE ACCOUNT. Securities Intermediary hereby represents and warrants
to Secured Party and Pledgor that (a) the Account has been established solely in
the name of Pledgor as recited above, (b) Exhibit A annexed hereto is a complete
and accurate statement of the Account and the financial assets carried therein
and any free credit balance thereunder as of the date thereof, (c) Exhibit A
does not reflect any financial assets which are registered in the name of
Pledgor, payable to its/his/her order, or specially endorsed to it/him/her,
which have not been endorsed to Securities Intermediary or in blank, (d) the
security entitlements arising out of the financial assets carried in the Account
and such free credit balance are valid and legally binding obligations of
Securities Intermediary, and (e) except for the claims and interest of Secured
Party and Pledgor in the Account (subject to any claim in favor of Securities
Intermediary permitted under Section 2), Securities Intermediary has no
knowledge of any claim to or interest in Account. Securities Intermediary will
treat all property held by it in the Account as financial assets under Article 8
of the Uniform Commercial Code as adopted by the State of Michigan.

         2. LIENS. Securities Intermediary hereby acknowledges the security
interest granted to Secured Party by Pledgor. Securities Intermediary hereby
confirms that the Account is a cash account and that it will not advance any
margin or other credit to Pledgor therein, either directly by executing purchase
orders in excess of any credit balance or money market mutual funds held in the
Account, executing sell orders on securities not held in the Account or by
allowing Pledgor to trade in instruments such as options and commodities
contracts that create similar obligations, nor hypothecate any securities
carried in the Account. Securities Intermediary hereby confirms that the Pledgor
has no check writing privileges or line of credit or credit card privileges
under the Account

<PAGE>   14

and that no such privileges shall be provided Pledgor under the Account as long
as this Agreement is in effect. Securities Intermediary hereby waives and
releases all liens, encumbrances, claims and rights of setoff it may have
against the Account or any financial asset carried in the Account or any credit
balance in the Account and agrees that, except for payment of its customary fees
and commissions pursuant to the Customer Agreement, it will not assert any such
lien, security interest, encumbrance claim or right against the Account or any
financial asset carried in the Account or any credit balance in the Account.
Securities Intermediary covenants and agrees that it will not enter into an
account control agreement with a third party with respect to the Account or
otherwise agree with any third party that Securities Intermediary will comply
with entitlement orders concerning the Account originated by such third party
without the prior written consent of Secured Party and Pledgor. Securities
Intermediary will promptly notify Secured Party and Pledgor if any person
asserts any lien, security interest, encumbrance or adverse claim against the
Account or in any financial asset carried therein.

         3. CONTROL. Securities Intermediary covenants and agrees that it will
comply with entitlement orders originated by Secured Party concerning the
Account at any time without further consent by Pledgor. Neither Pledgor nor
Securities Intermediary may make trades of financial assets held in the Account
without the prior written consent of Secured Party.

         4. NO WITHDRAWALS. Notwithstanding the provisions of Section 3 above,
Securities Intermediary shall neither accept nor comply with any entitlement
order from Pledgor withdrawing any financial assets from the Account or
directing the transfer of any financial assets held in the Account to any other
account maintained at Securities Intermediary or any other entity other than
Secured Party nor deliver any such financial assets to Pledgor nor pay any free
credit balance or other amount owing, from Securities Intermediary to Pledgor
with respect to the Account without the prior written consent of Secured Party.

         5. DUPLICATE STATEMENTS AND NOTICES. Securities Intermediary will send
copies of all statements, confirmations, notices of claims and other
correspondence concerning the Account simultaneously to each of Pledgor and
Secured Party at the addresses set forth below.

         6. SECURITIES INTERMEDIARY'S DUTIES. Except for permitting a withdrawal
or payment in violation of Section 4 above, permitting a trade in violation of
Section 3 above, or advancing margin or other credit or providing check writing
privileges or line of credit or credit card privileges to Pledgor in violation
of Section 2 above, Securities Intermediary shall have no responsibility or
liability to Secured Party for making trades of financial assets held in the
Account at the direction of Pledgor, or his authorized representatives, or
complying with entitlement orders concerning the Account from Pledgor, or his
authorized representatives, which are received by Securities Intermediary before
Securities Intermediary receives a Notice of Exclusive Control. Securities
Intermediary shall have no responsibility or liability to Pledgor for complying
with a Notice of Exclusive Control or complying with entitlement orders
concerning the Account originated by Secured Party. Securities Intermediary
shall have no duty to investigate or make any determination as to whether a
default exists under any agreement between Pledgor and Secured Party and shall

                                       2

<PAGE>   15

comply with a Notice of Exclusive Control even if it believes that no such
default exists. This Agreement does not create any obligation or duty of
Securities Intermediary other than those expressly set forth herein.

         7. TAX REPORTING. All items of income, gain, expense, and loss
recognized in the Account shall be reported to the Internal Revenue Service and
all state and local taxing authorities under the name and taxpayer
identification number of Pledgor.

         8. CUSTOMER AGREEMENT AND SECURITIES INTERMEDIARY'S JURISDICTION. In
the event of a conflict between this Agreement and any other agreement between
the Securities Intermediary and the Pledgor, the terms of this Agreement will
prevail. Regardless of any provision in such agreement, the State of Michigan
shall be deemed to be Securities Intermediary's location for the purposes of
this Agreement and the perfection and priority of Secured Party's security
interest in the Account.

         9. TERMINATION. The rights and powers granted herein to Secured Party
have been granted in order to perfect its security interest in the Account, are
powers coupled with an interest and will neither be affected by the death,
dissolution or bankruptcy of Pledgor nor by the lapse of time. The obligations
of Securities Intermediary under Sections 2, 3, 4, and 5 above shall continue in
effect until the security interest of Secured Party in the Account has been
terminated and Secured Party has notified Securities Intermediary of such
termination in writing. Upon receipt of such notice the obligations of
Securities Intermediary under Sections 2, 3, 4 and 5 above with respect to the
operation and maintenance of the Account after the receipt of such notice shall
terminate, Secured Party shall have no further right to originate entitlement
orders concerning the Account, and Securities Intermediary may take such steps
as Pledgor may request to vest full ownership and control of Account in Pledgor,
including, but not limited to, transferring all of the financial assets and
credit balances in the Account to another securities account in the name of
Pledgor or his designee.

         10. THIS AGREEMENT. This Agreement, the schedules and exhibits hereto
and the agreements and instruments required to be executed and delivered
hereunder set forth the entire agreement of the parties with respect to the
subject matter hereof and supersede and discharge all prior agreements (written
or oral) and negotiations and all contemporaneous oral agreements concerning
such subject matter and negotiations. There are no oral conditions precedent to
the effectiveness of this Agreement.

         11. AMENDMENTS. No amendment, modification or termination of this
Agreement or waiver of any right hereunder shall be binding on any party hereto
unless it is in writing and is signed by the party to be charged.

         12. SUCCESSORS. The terms of this Agreement shall be binding upon, and
shall inure to the benefit of, the parties hereto and their respective corporate
successors or heirs and personal representatives.

                                       3

<PAGE>   16

         13. SEVERABILITY. If any term or provision set forth in this Agreement
shall be invalid or unenforceable, the remainder of this Agreement, or the
application of such terms or provisions to persons or circumstances, other than
those to which it is held invalid or unenforceable, shall be construed in all
respects as if such invalid or unenforceable term or provision were omitted.

         14. NOTICES. Any notice, request or other communication required or
permitted to be given under this Agreement shall be in writing and deemed to
have been properly given when delivered in person, or when sent by telecopy or
other electronic means and electronic confirmation of receipt is received or two
days after being sent by certified or registered United States mail, return
receipt requested, postage prepaid, addressed to the party at the address set
forth next to such parties' name at the heading of this Agreement. Any party may
change its address for notices in the manner set forth above.

         15. RULES OF CONSTRUCTION. In this Agreement, words in the singular
number include the plural, and in the plural include the singular; words of the
masculine gender include the feminine and the neuter, and when the sense so
indicates words of the neuter gender may refer to any gender and the word Aor@
is disjunctive, but not exclusive. The captions and section numbers appearing in
this Agreement are inserted only as a matter of convenience and do not define,
limit or describe the scope or intent of the provisions of this Agreement.

         16. CHOICE OF LAW. The parties hereto agree that certain material
events, occurrences and transactions relating to this Agreement bear a
reasonable relationship to the State of Michigan. The validity, terms,
performance and enforcement of this Agreement shall be governed by those laws of
the State of Michigan which are applicable to agreements which are negotiated,
executed, delivered and performed solely in the State of Michigan.

         17. COUNTERPARTS. This Agreement may be executed in any number of
counterparts, all of which shall constitute one and the same instrument, and any
party hereto may execute this Agreement by signing and delivering one or more
counterparts.

         18. JURY WAIVER. THE PARTIES HERETO ACKNOWLEDGE THAT THE RIGHT TO TRIAL
BY JURY IS A CONSTITUTIONAL ONE, BUT THAT IT MAY BE WAIVED. EACH PARTY, AFTER
CONSULTING (OR HAVING HAD THE OPPORTUNITY TO CONSULT) WITH COUNSEL OF THEIR
CHOICE, KNOWINGLY AND VOLUNTARILY, AND FOR THEIR MUTUAL BENEFIT WAIVES ANY RIGHT
TO TRIAL BY JURY IN THE

                                       4

<PAGE>   17

EVENT OF LITIGATION REGARDING THE PERFORMANCE OR ENFORCEMENT OF, OR IN ANY WAY
RELATED TO, THIS AGREEMENT OR THE INDEBTEDNESS.

                                  COMERICA BANK
Addresses:

35405 Grand River
                                  By:  Ronald M. Ruks
                                     -------------------------------------------
Farmington, MI 48335
Telecopy No.:                     Its:  Assistant Vice President
              -------------           ------------------------------------------

                                  GENOMIC SOLUTIONS, INC.:

4355 Varsity Drive
                                  By: Jeffrey S. Williams
                                     -------------------------------------------
Suite E
Ann Arbor, MI 48108
                                  Its: President and CEO
                                     -------------------------------------------
Telecopy No.:
              --------------
                                  COMERICA SECURITIES

                                  By: Michael J. Wilk
----------------------------         -------------------------------------------
----------------------------
                                  Its: Managing Director
----------------------------         -------------------------------------------

Telecopy No.:
              --------------

                                       5

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