Document:

EX-10.13

 Exhibit 10.13 

ROYALTY TRANSFER AGREEMENT 

This Royalty Transfer Agreement (the “Agreement”) is made and entered into on May 26, 2016 (the “Effective
Date”), by and between TCR2, Inc., a Delaware corporation (the “Company”), MPM Oncology Charitable Foundation, Inc. a Massachusetts charitable foundation (the
“MPM Charitable Foundation”) and the UBS Optimus Foundation, a Swiss charitable foundation “Optimus.” and together with the MPM Charitable Foundation, the “Charitable Foundations”). 

WHEREAS, certain investors of the Company have requested that the Company enter into this Agreement providing for the transfer of 1.0%
of Net Sales on the term and conditions outlined below; and 
 WHEREAS, the Company is willing to enter into this Agreement in
connection with such request. 
 NOW, THEREFORE, the Company, the MPM Charitable Foundation and Optimus agree as follows: 

Section 1: Definitions 
 Definitions. The
following terms, as used herein, have the following meanings: 
 “Affiliate” shall mean any legal entity (such as a corporation,
partnership, limited liability company, etc.) that is directly or indirectly controlled by, or is under common control of the Company. For the purposes of this definition, “control” shall mean direct or indirect (i) beneficial
ownership of at least 50% of the voting securities of a legal entity; or (ii) a 50% or greater interest in the net assets or profits of a legal entity. 

“Bad Debt” shall mean any amounts booked as such on the Company’s financial statements, prepared in accordance with GAAP. 

“Company Products” shall mean any product developed or owned by the Company requiring pro-market
regulatory approval, provided that any product developed or owned by the Company that references, practices or incorporates, or (if such intellectual property was not owned or controlled by the Company ), would infringe, only Post-IPO IP shall not be deemed a “Company Product” hereunder. Further, notwithstanding anything to the contrary herein, for the avoidance of doubt. Company Products shall not include any products that are
discovered, developed, manufactured and/or commercialized by or on behalf of, or are covered by intellectual property (whether or not patentable) of, any person or entity that is an acquiror or merger partner of Company, becomes an Affiliate of the
Company by reason of any transaction in connection with the sale of all or substantially all of the stock and/or assets of the Company (such transaction, an “Acquisition”), or an assignee of this Agreement in connection with any of
the aforementioned transactions, provided that(he discovery, development, manufacture and/or commercialization of such product arc performed without use of Pre-Acquisition IP. 

“End of the Year” shall mean December 31 of a given calendar year. 

 “Licensee” shall mean any party that is not an Affiliate that has been granted a license to
the Company Products. 
 “Net Sales” means, with respect to Company Products, the gross amounts invoiced in arm’s length transactions
by the Company or its Affiliates or Licensees to third parties for sales of such Company Product, less good faith estimates of the following deductions to the extent specifically relating to sales of such Company Products, which will be adjusted to
reflect actual deductions on a periodic basis (no less frequently than annually): 
  

	 	a)	 discounts (including trade, quantity, and cash discounts) actually allowed, cash and noncash coupons, and
retroactive price reductions (including to governmental entities or agencies, purchasers, reimburses, customers, distributors, wholesalers, and group purchasing and managed care organizations or entities (and other similar entities and
institutions); 

  

	 	b)	 credits or allowances, if any, on account of price adjustments, recalls, claims, damaged goods, rejections or
returns of items previously sold (including Company Products returned in connection with recalls or withdrawals) and amounts written off by reason of Bad Debt; provided, that if the debt is [hereafter paid, the corresponding amount will be added to
the Net Sales of the period during which it is paid; 

  

	 	c)	 rebates (or their equivalent), administrative fees, and any other similar allowances granted by Company, its
Affiliates or Licensees (including to governmental authorities, purchasers, reimbursers, customers, distributors, wholesalers, and managed care organizations and entities (and other similar entities and institutions) that effectively reduce the
selling price or gross sales of the Company Products; 

  

	 	d)	 insurance, customs charges, freight, postage, shipping, handling, and other transportation costs incurred by
Company, its Affiliates or Licensees in shipping Company Products: 

  

	 	e)	 to the extent not already deducted or excluded from the gross amounts invoiced, import taxes, export taxes,
excise taxes, sales taxes, value-added taxes, consumption taxes, dutis or other taxes levied on, absorbed, determined, and/or imposed with respect to such sales, including pharmaceutical excise taxes (such as those imposed by the United States
Patient Protection and Affordable Care Act of 2010 (Pub. L. No. 111-48) and other comparable laws), but excluding income or net profit taxes or franchise taxes of any kind; and 

 

	 	f)	 oilier similar or customary deductions taken in the ordinary course of business in accordance with GAAP.

 Net Sales will be determined in accordance with GAAP except with respect to the pharmaceutical excise taxes described in clause
(e) above. Net Sales will not be imputed to transfers of Company Products for use in clinical trials, non-clinical development activities, or other development activities that might he required by
regulatory authorities with respect to Company Products, for bona fide charitable purposes, for compassionate use, for indigent patient programs, or as free samples. 

 Notwithstanding the foregoing, in the event a Company Product contains another active ingredient that is not
a Company Product itself (such Company Product, a “Combination Product”). Net Sales of such Company Product for a particular country for the purpose of determining royalties due hereunder shall be calculated using commercially
reasonable accounting practices. 
 “Company IP” shall mean (a) any invention discovered or developed and/or (b) any patents
and/or patent applications in each case which is in whole or in pail developed by, or otherwise becomes owned or controlled by, the Company. 
 “Post-IPO IP” shall mean Company IP that, in the case of (a) that was discovered or developed, or in the ease of (b) that has a priority dale, after an initial public offering of the Company’s
common stock pursuant to an effective registration statement under the Securities Act of 1933, 

“Pre-Acquisition IP” shall mean Company IP that, in the case of (a) that was discovered or
developed, or in the case of (b) that has a priority date, prior to an Acquisition of the Company. 
 Section 2: Payments/Termination

 2.1 Payments to MPM Charitable Foundation. Within 120 days of the End of the Year, the Company agrees to pay to the
MPM Charitable Foundation 0.5% of all global Net Sales of any Company Products received by the Company, its Licensees or its Affiliates during the prior calendar year. The Company’s payment obligations to the MPM Charitable Foundation under
this Section 2.1 shall terminate immediately upon the winding up or dissolution of the MPM Charitable Foundation. 

2.2 Payments to Optimus. Within 120 days of the End of the Year, the Company agrees to pay to Optimus 0.5% of all global Net Sales
of any Company Products received by the Company, its Licensees or its Affiliates during the prior calendar year. The Company’s payment obligations to Optimus under this Section 2.2 shall terminate immediately upon the expiration or
termination of the Contribution Agreement relating to the Quality and Access Initiative for Health in Resource Poor Settings between Optimus and Oncology Impact Fund (Cayman) Management L.P. (“OIF Management”). 

2.3 Terminal ion/Step-Down. Notwithstanding the foregoing, Company’s obligation to pay royalties under Section 2.1 and
2.2 for a Company Product shall terminate on a country-by-country basis upon the later of (i) the date that is the twelfth (12th) anniversary of the first commercial sale of that Company Product in such country, and (ii) the expiration of the last to expire valid patent claim of any
Pre-Acquisition IP (other than Post-IPO IP) covering such Company Product in such country (the “Royalty Term”). If the Royalty Term pursuant to clause
(i) of this Section 2.3 exceeds the Royalty Term pursuant to clause (it), the royalty rates under Sections 2.1 and 2.2 shall each be reduced by Fifty percent (50%) for the remainder of the Royalty Term, such that the new
royalty rates under Section 2.1 and 2.2 shall be 0.25% each for the remainder of the Royalty Term. If MPM Oncology Impact Management GP, LP ceases for any reason to serve as the general partner for the OIF Management, then this Agreement
shall terminate immediately. 

 Section 3: Miscellaneous 

3.1 Binding Agreement and Assignment. This Agreement shall be binding upon and inure to the benefit of the Company and its
successors and assigns. The Company may not transfer, assign or sell any rights with respect to any Company Products without securing from the transferee, assignee or acquirer, as the case may be, an acknowledgement of its continuing obligations
under this Agreement. The Charitable Foundations may not assign any of their rights or obligations under this Agreement to any individual or entity without the express written prior consent of the Company. 

3.2 Entire Agreement, Headings, and Modification. This Agreement contains the entire understandings of the parties with respect to
the subject matter herein, and supersedes all previous agreements (whether oral or written), negotiations, and discussions. The descriptive headings of the sections of this Agreement are inserted for convenience only and shall not control or affect
the meaning or construction of any provision hereof. Any modifications or amendments to this Agreement must be made in writing and signed by both parties. 

3.3 Choice of Law. This Agreement shall be construed, governed, interpreted, and applied in accordance with the laws of the
Commonwealth of Massachusetts, exclusive of its conflicts of law provisions. Any unresolved controversy or claim arising out of or relating to this Agreement shall be submitted to arbitration by one arbitrator mutually agreed upon by the parties,
and if no agreement can be reached within 30 days after names of potential arbitrators have been proposed by the American Arbitration Association (the “AAA”), then by one arbitrator having reasonable experience in licensing and
royalty transactions who is chosen by the AAA. The arbitration shall lake place in Boston, Massachusetts, in accordance with the AAA rules then in effect, and judgment upon any award rendered in such arbitration will be binding and may be entered in
any court having jurisdiction thereof. 
 3.4 Waiver. The waiver by any party of the breach of any covenant or provision in this
Agreement shall not operate or be construed as a waiver of any subsequent breach by such party. 
 3.5 Severability. In the event
a court of competent jurisdiction declares any term or provision of this Agreement to be invalid or unenforceable for any reason, this Agreement will remain in full force and effect, and either: (a) the invalid or unenforceable provision(s)
will be modified to the minimum extent necessary to make such provision(s) valid and enforceable; or (b) if such a modification is not possible, this Agreement will be interpreted as if such invalid or unenforceable provisions) were not a pail
of this Agreement. 
 3.6 Counterparts. This Agreement may be executed in any number of counterparts, all of which will
constitute one and the same instrument, and will be an original of this Agreement. 
 [Signatures on Following Page] 

 IN WITNESS WHEREOF, this Agreement has been executed by the parties hereto through their duly authorized
officers as of the Effective Date. 
  

			
	TCR2, INC
		
	By:	 	 /s/ Patrick Baeuerle

	Name:	 	Patrick Baeuerle
	Title:	 	President

  

			
	MPM ONCOLOGY CHARITABLE FOUNDATION
		
	By:	 	 /s/ Ansbert Gadicke

	Name:	 	Ansbert Gadicke
	Title:	 	President
	
	UBS OPTIMUS FOUNDATION
		
	By:	 	 /s/Phyllis Costanza

	Name:	 	Phyllis Costanza
	Title:	 	CEO
	and:	 	 /s/Karin Schumacher

	Name:	 	Karin Schumacher
	Title:	 	Business Manager

 [Royalty Transfer Agreement]EX-10.14

 Exhibit 10.14 

LETTER AGREEMENT 
 May 26, 2016 

TCR2, Inc. 

Re: Execution of Royalty Transfer Agreement 
 To Whom It May
Concern: 
 Reference is made to that certain Series A Preferred Stock Purchase Agreement, dated as of October 16, 2015 (“Purchase
Agreement”), by and among TCR2, Inc., a Delaware corporation (the “Company”) and the other parties thereto, as amended by that certain Amendment No. 1 to Series A
Preferred Stock Purchase Agreement, dated as of January 29, 2016, by and among the Company and parties listed on the signature pages thereto. By executing and delivering this letter, in connection with the purchase by UBS Oncology Impact Fund
LP. (“OIF”) of 3,258,427 shares of Series A Preferred Stock of the Company at the Additional Closing (as defined in the Purchase Agreement), OIF MPM Oncology Impact fund Charitable foundation, the UBS Optimus foundation and the
Company hereby acknowledges and agree as follows: 
  

	 	1.	 A portion of the cash consideration paid by OIF to the Company in respect of shares of Series A Preferred Stock
shall be treated as consideration for the right to receive from the Company one percent (1.0%) of (i) all global Net Sales of any Company Products and (ii) any License Income, in both eases received by the Company (such payments, the
“Royalty Stream”). 

  

	 	2.	 Effective immediately subsequent to the purchase by OIF of the Royalty Stream, OIF hereby transfers its rights
under the Royalty Stream to the MPM Charitable Foundation and UBS Optimus Foundation by directing the Company to execute, deliver and perform that certain Royalty Transfer Agreement among the Company, MPM Charitable Foundation, and UBS Optimus
Foundation (the “RTA”), which RTA provides for, among other things, payment of 50% of the Royalty Stream to the MPM Charitable Foundation and payment of 50% of the Royalty Stream to UBS Optimus foundation. 

Unless otherwise required by a “determination” within the meaning of Section 1313 of the Internal Revenue Code of 1986, as amended, and the
Treasury Regulations thereunder (and any comparable position of state, local or non-U.S. tax law) the parties agree, that they and their affiliates shall (A) prepare and file all tax returns required to
be filed by the parties or their Affiliates in a manner consistent with the foregoing, (B) take no position on any lax return, or in any audit or other proceeding with respect to taxes in a manner that is inconsistent with the foregoing. 

This letter shall be governed by and construed and enforced in accordance with the laws of the State of Delaware. Without giving effect to the principles of
conflicts of law thereof. This letter and the RTA together constitute the full and entire understanding and agreement between the parties with respect to the subject matter hereof, and any other written or oral agreement relating to the subject
matter hereof existing between the parties are expressly canceled. This letter may also be executed and delivered by facsimile signature and in two or more counterparts, each of which shall be deemed an original, but all of which together shall
constitute one and the same instrument. Capitalized terms used but not defined herein shall have the meaning scribed lo them under the RTA. 

(Signature Page Follows) 

 AGREED & ACCEPTED this 1st day of April, 2016

  

			
	TCR2, INC.
		
	By:	 	 /s/ Patrick Baeuerle

	Name:	 	Patrick Baeuerle
	Title:	 	President
	
	MPM CHARITABLE FOUNDATION
		
	By:	 	 /s/ Ansbert Gadicke

	Name:	 	Ansbert Gadicke
	Title:	 	President
	
	UBS OPTIMUS FOUNDATION
		
	By:	 	 /s/Phyllis Costanza

	Name:	 	Phyllis Costanza
	Title:	 	CEO
	and:	 	 /s/Karin Schumacher

	Name:	 	Karin Schumacher
	Title:	 	Business Manager
	
	 /s/Ansbert Gadicke

	Ansbert Gadicke

 on behalf of 
 MPM ONCOLOGY
IMPACT MANAGEMENT GP LLC 
 in its capacity as general partner of 

MPM ONCOLOGY IMPACT MANAGEMENT LP 
 in its capacity as general
partner of 
 ONCOLOGY IMPACT FUND (CAYMAN) MANAGEMENT L.P. 
 in
its capacity as general partner of 
 UBS ONCOLOGY IMPACT FUND L.P. 

[Direction Letter]

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