Document:

Exhibit 10.6

 

AMENDMENT TO EMPLOYMENT AGREEMENT

 

TO INCREASE ANNUAL SALARY

 

Re: EMPLOYMENT AGREEMENT entered into as of
January 20, 2011, by and between Cancer Prevention Pharmaceuticals, Inc., a Delaware Company (“CCP”) and Jeffrey Jacob
(“Employee”).

 

Effective September 2, 2013 (the “Amendment
Effective Date”), Employee and CPP hereby agree to amend section 1 Salary; Equity Awards of the above stated agreement to
increase the annual salary to $310,000.00.

 

Except as expressly provided above, all other
terms and conditions of this agreement remain in full force and effect unchanged.

 

If the foregoing is acceptable, please so indicate
by signing where indicated below.

 

Jeffrey Jacob (Employee)

  

	/s/ Jeffrey Jacob	 
	Signature	 

 

Date: 9-2-13

 

Cancer Prevention Pharmaceuticals, Inc. (CPP)

  

	/s/ Eugene Gerner	 
	Eugene Gerner, CSO	 

 

Date: 9-2-13Exhibit 10.7

 

		
        Cancer Prevention Pharmaceuticals,
        LLC

        1760 E. River Road, Suite 250

        Tucson, AZ 85718

        Phone: 520-908-7774

 

	Christopher Richied	February 1, 2013

 

Dear Christopher:

 

It is our pleasure to offer you employment at Cancer Prevention
Pharmaceuticals, Inc. (the “Company”) as Chief Financial Officer for the Company. Your place of work will be the CPP
headquarters at 1760 E. River Road, Suite 250, Tucson, AZ 85718 beginning February 1, 2013 as a Part-Time Employee (20 hours per
week). You will convert to full-time status at a mutually acceptable date. The following outlines the key elements of your employment:

 

1.    Salary; Equity Awards

 

Your starting annual salary will be $102,000.00 (which
reflects an adjustment for your half-time status from a nominal $204,000 full-time annual salary) payable in bi-weekly installments
and subject to deductions for taxes and other withholdings as required by law and the polices of the Company.

 

Your annual salary will be subject to adjustment based
on an annual review of your performance during the previous year, the Company’s overall performance during that year, and
the Company’s policy then in effect for salary adjustments. The first review of your performance and annual salary will occur
at the end of the Company’s fiscal year in which your employment began.

 

In connection with the services you have provided the
Company as a consultant, the Company earlier granted you an Award of restricted stock under the Company’s 2010 Equity Incentive
Plan. That Award was governed under a separate agreement. For purposes of that agreement, your acceptance of employment will be
deemed a continuation of your status as a Service Provider to the Company and will not interrupt the running of the Period of Restriction
under that agreement.

 

2.    Benefits

 

You will be eligible to participate in the Company’s
benefit programs. These programs include:

 

		a.	Medical, dental, and vision insurance for you and your dependents, which may require a modest contribution on your part based
on Company policy.

 

 

www.CanPrevent.com

 

     

     

    

 

		b.	The Company’s 2010 Equity Incentive Plan. In addition to the award mentioned above, you may be eligible for additional
awards in recognition of your service.

 

		c.	Ten paid holidays, (New Year’s Day, Memorial Day, Independence Day, Labor Day, Veteran’s Day, Thanksgiving-2 days,
Christmas-2 days, and one “floating holiday” defined per company policy.

 

		d.	Paid time off (PTO) is accrued throughout the duration of employment, including ten paid vacation days.

 

		e.	Reimbursement of business expenses in accordance with Company policy in effect at the time.

 

3.   Duties and Responsibilities

 

A Chief Financial Officer is classified as a regular,
exempt position. Although you will begin your employment on a half-time basis, your role in the position, and the concomitant tasks
and responsibilities, are expected to grow such that the position will be full time. Your duties and responsibilities include managing
accounting, finance, fundraising, and other related CFO duties. You will report to Jeffrey Jacob, the CEO.

 

4.   Start Date

 

It is recognized that your duties will begin on February
1, 2013.

 

As a condition to your accepting employment, you must sign and deliver
to the Company its standard Employee Intellectual Property, Confidentiality and Non-Compete Agreement before your start date.

 

You will be an at-will employee and this letter is not to be considered
a contract guaranteeing employment for any specific duration. As an at-will employee, both you and the Company have the right to
terminate your employment at any time.

 

This offer for employment is in effect for ten days. If not accepted
by the end of that ten-day period, the offer for employment will be deemed withdrawn.

 

We are looking forward to your joining Cancer Prevention Pharmaceuticals.

 

	 	Sincerely,	 	 	 
	 	 	 	 	 
	 	/s/ Jeffrey Jacob	 	 	 
	 	Jeffrey Jacob	 	Agreed to and Accepted by:	 
	 	CEO	 	 	 
	 	 	 	/s/ Christopher
    Richied	 
	 	 	 	Date	 8/29/13	 

 

 

www.CanPrevent.comExhibit 10.8

 

		
        Cancer Prevention Pharmaceuticals,
        Inc.

        1760 E. River Road, Suite 250

        Tucson, AZ 85718

        Phone: 520-908-7774

 

August 29, 2013

 

Christopher Richied

 

Dear Chris,

 

I am pleased to inform you that, effective September 2, 2013, your
employment with CPP will be as a full-time, regular employee. You will be paid at a full-time rate based on an annual salary of
$220,000, which represent an increase in salary of $ 118,000.00 over your present compensation.

 

Thank you for your exemplary contributions to CPP. I look forward
to achieving great things together at Cancer Prevention Pharmaceuticals.

 

	 	Sincerely,		 	 	 	 
	 	 	 	 	 	 	 
	 	/s/ Jeff Jacob	 	 	 	 	 
	 	Jeff Jacob	 	Agreed to and Accepted by:	 
	 	CEO	 	 	 	 	 
	 	 	 	 	/s/ Christopher Richied	 
	 	 	 	 	Date:	 	 

 

 

www.CanPrevent.comExhibit 10.9

 

		
        Cancer Prevention Pharmaceuticals,
        Inc.

        1760 E. River Road, Suite 250

        Tucson, AZ 85718

        Phone: 520-908-7774

 

July 30, 2012

 

Dr. Eugene Gerner

 

Dear Gene:

 

It is our pleasure to offer you employment at Cancer Prevention
Pharmaceuticals, Inc. (CPP) as Chief Scientific Officer for the Company. Your place of work will be the CPP headquarters at 1760
E. River Road, Suite 250, Tucson, AZ 85718 beginning August 1, 2012. The following outlines the key elements of your employment:

 

1.   Salary; Equity Awards

 

Your starting annual salary will be $36,000.00, payable
in bi-weekly installments and subject to deductions for taxes and other withholdings as required by law and the polices of the
Company.

 

Your annual salary will be subject to adjustment based
on an annual review of your performance during the previous year, the Company’s overall performance during that year, and
the Company’s policy then in effect for salary adjustments. The first review of your performance and annual salary will occur
at the end of the Company’s fiscal year following the first full year of employment.

 

2.    Benefits

 

You will be eligible to participate in the Company’s
benefit programs. These programs include:

 

		a.	Medical, dental, and vision insurance for you and your dependents, which may require a modest contribution on your part based
on Company policy.

 

		b.	The Company’s Stock Option Plan. In addition to the initial award described above, you may be eligible for additional
awards in recognition of your service.

 

		c.	Ten paid holidays, (New Year’s Day, Memorial Day, Independence Day, Labor Day, Veteran’s Day, Thanksgiving-2 days,
Christmas-2 days, and one “floating holiday” defined per company policy).

 

 

www.CanPrevent.com

 

     

     

    

 

		d.	Paid time off (PTO) is initially accrued at 4.61 hours per pay period (15 days per year). PTO will increase based upon years
of service per company policy.

 

		e.	Reimbursement of business expenses in accordance with Company policy in effect at the time.

 

3.    Duties and Responsibilities

 

A Chief Scientific Officer is classified as a regular,
exempt position. Your duties and responsibilities include scientific oversight, and overall technical and scientific strategy for
the company. You will report to Jeffrey Jacob, the Chief Executive Officer. You will not have any direct reports at this time.
You will be responsible for laboratory oversight in the event that CPP opens a laboratory in the future.

 

4.    Start Date

 

It is recognized that your duties will begin on August
1, 2012.

 

As a condition to your accepting employment, you must sign and deliver
to the Company its standard Employee Intellectual Property, Confidentiality and Non-Compete Agreement before your start date.

 

This letter is not to be considered a contract guaranteeing employment
for any specific duration. As an at-will employee, both you and the Company have the right to terminate your employment at any
time.

 

This offer for employment is in effect for ten days. If not accepted
by the end of that ten-day period, the offer for employment will be deemed withdrawn.

 

We are looking forward to your joining Cancer Prevention Pharmaceuticals.

 

	Sincerely,	 	 	 
	 	 	 	 
	/s/ Jeffrey Jacob	 	 	 
	Jeffrey Jacob	Agreed to and Accepted by:	 
	CEO	 	 	 
	 	/s/ Eugene Gerner	 
	 	Date	July 30, 2012	 

 

cc: Christine Brannen

Enclosures: Job Description

 

 

www.CanPrevent.comExhibit 10.10

 

 

January 13, 2014

 

Gene Gerner

 

Dear Gene:

 

I am pleased to inform you that, effective February 1, 2014, your
employment with CPP as its Chief Scientific Officer on a halftime employee basis will reflect an increase in salary to $120,000
per year (equivalent to a full-time salary of $240,000 per year).

 

Thank you for your exemplary contributions to CPP. I look forward
to achieving great things together at Cancer Prevention Pharmaceuticals!

 

	Sincerely,	 
	 	 
	/s/Jeffrey Jacob	 
	Jeffrey Jacob	 
	CEO	 

 

Agreed to and Accepted by:

 

	/s/ Eugene
    Gerner	 	 2/1/2014
	Eugene Gerner, Ph.D.	 	Date

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