Document:

Exhibit 10.1

 

FIRST AMENDMENT TO

AMENDED AND COMPLETELY RESTATED LEASE

 

This First Amendment to Amended
and Completely Restated Lease (this “Amendment”) is entered into to be effective as of November 1, 2022 (the “Effective
Date”), by and between Lauren Real Estate Holding LLC, an Ohio limited
liability company (“Landlord”) and Quanex IG Systems, Inc., an
Ohio corporation (“Tenant”) and is intended to amend that certain Amended and Completely Restated Lease, dated August
25, 2016 (the “Lease”). Hereafter, Landlord and Tenant are sometimes referred to as a “party” and
collectively as the “parties”.

 

RECITALS

 

A.            Capitalized terms used herein but not otherwise defined shall have the meanings assigned to such terms in the Lease.

 

B.            Landlord and Tenant are parties to the Lease.

 

C.            Pursuant to Section 26.14 of the Lease, the Lease may be amended by a writing signed by Landlord and Tenant.

 

D.            Landlord and Tenant have agreed to enter into this Amendment to memorialize the Extension Premises Rent, extend Tenant a third renewal
option and address certain other matters as set forth herein.

 

OPERATIVE PROVISIONS

 

NOW, THEREFORE, in
consideration of the foregoing Recitals, which Recitals are incorporated herein by this reference, for good and valuable consideration,
the receipt and sufficiency of which is hereby acknowledged, and in consideration of the mutual covenants contained herein, the parties
agree as follows:

 

		1.	Proportionate Share. Section 1.4(b) of the Lease
is hereby amended and restated in its entirety as follows:

 

“(b)       Notwithstanding
anything to the contrary, the parties stipulate and agree that, as of November 1, 2022, the Original Premises consists of 313,595 square
feet of rentable area and the Expansion Premises consists of 60,000 square feet of rentable area, the Entire Property will contain 499,674
square feet of rentable area, and Tenant’s proportionate share thereof will be (74.77%) (“Tenant’s Proportionate
Share”).”

 

		2.	Original Premises Rent. Section 4.2(b) of the
Lease is hereby amended and restated in its entirety as follows:

 

“(b)       At
the beginning of the fourth (4th) Lease Year, and on each third (3rd) anniversary thereafter during the Term,
and during any Extension Term (each, a “Rent Reset Date”), the Original Premises Rent shall be adjusted for the
ensuing three (3) Lease Years by the percentage increase of the United States Department of Labor, Bureau of Labor Statistics,
Revised Consumer Price Index, all urban consumers, U.S. city average, all items (1982-1984 equals 100)
(the “CPI”), if any, as of the applicable Rent Reset Date over the CPI as of the next most recent preceding
Rent Reset Date. For purposes of the foregoing formula, the Effective Date shall be considered the initial Rent Reset
Date.”

 

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		3.	Expansion Premises Rent. Section 4.3(b) of the
Lease is hereby amended and restated in its entirety as follows:

 

“(b)       Tenant
will, from and after the Expansion Premises Commencement Date, pay Expansion Premises Rent on a monthly basis. The amount of each monthly
payment of Expansion Premises Rent (herein so called) shall be (i) for the period beginning on the Expansion Premises Commencement Date
and ending on the date immediately prior to the commencement of any Extension Term, the amount that would amortize ninety percent (90%)
of the amount determined pursuant to Section 4.3(a) hereof, in equal monthly installments, with an imputed annual interest rate of five
percent (5%) commencing on the Expansion Premises Commencement Date, over a period of fifteen (15) years, and (ii) during any Extension
Term, an amount equal to the product of (x) the Original Premises Rent applicable during such Extension Term, divided by (y) the
square footage of the Original Premises as set forth in the Lease, multiplied by (z) the square footage of the Expansion Premises
as set forth in the Lease. For the avoidance of doubt, notwithstanding anything to the contrary, during any Extension Term the Expansion
Premises Rent shall be equal to the Original Premises Rent when calculated on a per-square-footage basis.”

 

		4.	Obligation to Amend Lease. Section 4.3(c) of the
Lease is hereby deleted and removed in its entirety.

 

		5.	Additional Option to Renew. Section 6.1 of the
Agreement is hereby amended and restated in its entirety as follows:

 

“6.1         So
long as Tenant is not in default of this Lease beyond applicable notice and cure periods, Tenant shall have the right and option,
but not the obligation, to extend the Term of this Lease for up to three (3) periods of five (5) years each (each, an
“Extension Term”), commencing immediately following the expiration of the then current Term. Tenant may exercise
its right to extend the term of this Lease for each Extension Term by delivering written notice (an “Extension
Notice”) thereof to Landlord no less than six (6) months and no more than twelve (12) months before the expiration of the
then current Term of this Lease. Tenant’s lease of the Premises during each Extension Term shall be on all of the same terms
and conditions of this Lease, except that the Fixed Rent and Expansion Premises Rent shall be adjusted in accordance with Section
4.2 hereof.”

 

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		6.	Exhibit F. Exhibit F of the Lease is hereby deleted
and removed in its entirety.

 

		7.	Miscellaneous.

 

 (a)           Except as amended hereby, the Lease is and remains in full force and effect. All references to Lease shall hereafter mean and refer to the Lease as amended by this Amendment.

 

(b)          The
headings of the Sections of this Amendment have been inserted for convenience only and shall in no way modify or restrict any provisions
hereof, or be used to construe any such provisions.

 

(c)          
If any provision of this Amendment is held to be illegal, invalid or unenforceable under present or future laws, such provision
shall be fully severable, and this Amendment shall be construed and enforced as if such illegal, invalid or unenforceable provision had
never comprised a part of this Amendment.

 

(d)          
This Amendment, together with the Lease as amended hereby, constitutes the entire agreement between the parties, and supersedes
all prior negotiations, with respect to the subject matters set forth herein. This Amended may not be modified except by an instrument
in writing executed by the parties.

 

(e)          
This Amendment may be executed in multiple counterparts, each of which shall be considered an original but all of which taken together
shall constitute one and the same instrument.

 

(f)          
This Amendment shall be governed by and construed in accordance with the laws of the State of Ohio.

 

(g)          
Electronic signatures may be used in place of original signatures on this Amendment. The parties hereto intend to be bound by the
signatures on the electronic document, and hereby waive any defenses to the enforcement of the terms of this Amendment based on the use
of an electronic signature; provided, however, that each party hereby agrees to execute and provide to the other party an
original signature to this Amendment upon request.

 

[Signature Page Follows.]

 

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IN WITNESS WHEREOF, the parties
have executed this Amendment to be effective as of the Effective Date.

 

	 	LESSOR:
	 	 
	 	LAUREN REAL ESTATE HOLDING LLC, an Ohio limited liability
    company
	 	 
	 	By:	/s/ Kevin E. Gary
	 	Name:	Kevin E. Gary
	 	Its:	Manager
	 	 
	 	LESSEE:
	 	 
	 	QUANEX IG SYSTEMS, INC., an Ohio corporation
	 	  
	 	By:	/s/ Scott Zuehlke
	 	Name:	Scott Zuehlke
	 	Its:	Chief Financial Officer and Treasurer

 

    4Document

Exhibit 10.1    

Certain identified information, marked by [***], has been excluded from the exhibit because it is both not material and is the type that the Company treats as private or confidential.

AMENDMENT NO. 3 TO GLOBAL COLLABORATION AND LICENSE AGREEMENT
This Amendment No. 3 to Global Collaboration and License Agreement (this “Amendment No. 3”) is dated as of July 14, 2022, by and between INCYTE CORPORATION, a Delaware corporation, having its principal place of business at 1801 Augustine Cut-Off, Wilmington, DE 19803 (hereinafter “Incyte”), and MACROGENICS, INC., a Delaware corporation, having its principal place of business at 9704 Medical Center Drive, Rockville, MD 20850 (“MacroGenics”, together with Incyte, the “Parties” and each separately, a “Party”), and is meant to amend that certain Global Collaboration and License Agreement, dated as of October 24, 2017, between Incyte and MacroGenics and amended on March 15, 2018 (“Amendment No. 1”) and April 7, 2022 (“Amendment No. 2”). The Global Collaboration and License Agreement, Amendment No. 1, and Amendment No. 2 are referred to herein collectively as the “Agreement”.  Capitalized terms used and not otherwise defined herein shall have the meanings ascribed to such terms in the Agreement.
WHEREAS, the Parties wish to modify the Agreement to reflect changes agreed to between the Parties with respect to (a) the acceleration of payment for certain Milestones with respect to [***] and (b) the [***] of certain Milestones with respect to [***];
NOW, THEREFORE, IN CONSIDERATION of the mutual covenants contained herein, and for other good and valuable consideration the receipt and adequacy of which are hereby acknowledged, the Parties agree as follows:
1.Acceleration of First Development Milestones with respect to [***] Indications.  The Parties agree that the first Development Milestone set forth in Section 8.2(b) of the Agreement, [***] (including Incyte Monotherapy Studies and Incyte Combination Studies) [***] Milestone”) shall be deemed to have been achieved with respect to the Indications [***].  Incyte shall pay MacroGenics within [***] Business Days of the date hereof the amount of [***], representing payment for the achievement of such [***] Milestones.  The Parties agree that only [***] remains unachieved and potentially payable by Incyte in the future.
2.Removal of Certain Milestones and Payments for [***].  The Parties agree that:
a.The [***] shall not apply with respect to the Indication [***], and [***] for the [***] shall [***] with respect to the Indication of [***], whether by reason of (i) actually [***] in the Indication [***] or (ii) the occurrence of any of the events set forth in the final sentence in the first paragraph of Section 8.2 stating, “In addition, except with respect to the Breakthrough Designation Milestone, if for any reason any other Development Milestone corresponding to a Milestone payment does not occur prior to the occurrence of Regulatory Approval, then such prior non-occurring Development Milestone shall be deemed to occur concurrently with Regulatory Approval, and the applicable Milestone payments for the applicable Development Milestones shall become due and payable in accordance with this Section 8.2.”  For clarity, [***] by Incyte, its Affiliates, or sublicensees for a Monotherapy Regimen or Incyte Combination Regimen in the [***] any such Milestone payment.

b.The Regulatory Filing Milestone [***] set forth in Section 8.2(c) of the Agreement [***] respect to the Indication [***], and [***] of such Milestone [***] with respect to the [***].

c.The Approval Milestone [***] set forth in Section 8.2(d) of the Agreement [***] with respect to the Indication of [***], and [***] for the [***] Milestone shall [***] with respect to the Indication [***].

3.Entire Agreement; Remaining Provisions of the Agreement.  The Agreement, as supplemented and modified by this Amendment No. 3, contains the entire understanding of the parties with respect to the subject matter hereof and supersedes all prior agreements and understandings, oral or written, with respect to such matters, which the parties acknowledge have been merged into the Agreement.  Upon the effectiveness of this Amendment No. 3, on and after the date hereof, each reference in the Agreement to “this Agreement,” “hereunder,” “hereof,” “herein” or words of like import shall mean and be a reference to the Agreement, as amended hereby.  Except as provided herein, each of the other provisions of the Agreement shall remain in full force and effect.
4.Governing Law.  This Amendment No. 3 shall be governed by and construed under the laws of the State of New York, without giving effect to any choice of law principles that would require the application of the laws of a different state.
5.Execution in Counterparts.  This Amendment No. 3 may be executed in two (2) or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. This Amendment No. 3 may be executed by .pdf or other electronically transmitted signatures and such signatures shall be deemed to bind each Party as if they were the original signatures.
[remainder of page intentionally blank]

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IN WITNESS WHEREOF, the parties hereto have caused this Amendment No. 3 to Global Collaboration and License Agreement to be duly executed by their respective authorized signatories effective as of the date first indicated above.

			
	MACROGENICS, INC.

	By: /s/ Scott Koenig    
Name: Scott Koenig
Title: President and Chief Executive Officer 

	
	INCYTE CORPORATION 

	By: /s/ Vijay Iyengar                    
Name:  Vijay Iyengar
Title:  EVP, Global Strategy & Corporate Development 

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