Document:

Exhibit

AMENDING AGREEMENT #5
THIS AMENDING AGREEMENT made effective as of the 8th day of March, 2018.
BETWEEN:
ONCOYLYTICS BIOTECH INC.,
("ONCOLYTICS")
- and -
MATTHEW C. COFFEY,
(the "Employee")
WHEREAS the Employee is an officer of Oncolytics whose terms of employment are set forth in the Executive Employment Agreement ("Employment Agreement") dated effective January 1, 2013 as amended by an Amending Agreement #1 dated March 12, 2014, Amending Agreement #2 dated March 12, 2015, Amending Agreement #3 dated March 8, 2016, and Amending Agreement #4 dated February 23, 2017 (together the "Employment Agreement");
AND WHEREAS Oncolytics and the Employee wish to amend the Employment Agreement;
NOW THEREFORE in consideration of the mutual covenants contained in this Amending Agreement, and other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, it is agreed as follows:
		
	1
	Interpretation

This Amending Agreement is supplemental to and shall form one agreement with the Employment Agreement, and the Employment Agreement and this Amending Agreement shall be read together and have effect so far as practicable as though all the provisions thereof and hereof were contained in one instrument. In this Amending Agreement, including the recitals hereto, unless there is something within the subject matter or context inconsistent therewith, expressions herein, unless otherwise defined herein, have the same meanings as the corresponding expressions defined in the Employment Agreement.
		
	2
	Amendment to the Employment Agreement

The Employment Agreement Section 3 – Remuneration is amended as follows:

(1)Commencing January 1, 2018, Oncolytics shall pay to the Employee a salary of four hundred seventy-five thousand ($475,000) CANADIAN DOLLARS per annum, exclusive of bonuses, benefits and other compensation, payable in equal installments of nineteen thousand seven hundred ninety-one CANADIAN DOLLARS and sixty-seven cents ($19,791.67) on the 15th and last day of each month.  
		
	3
	Confirmation

The parties hereto hereby acknowledge and confirm that, except as specifically amended by the provisions of this Amending Agreement, all of the terms and conditions contained in the Employment Agreement are and shall remain in full force and effect, unamended, in accordance with the provisions thereof.
		
	4
	Miscellaneous

		
	(a)
	This Agreement shall be governed by and construed in accordance with the laws in force in the Province of Alberta.  The parties hereby submit to the jurisdiction of the Courts of Alberta.

		
	(b)
	The parties shall with reasonable diligence take all action, do all things, attend or cause their representatives to attend all meetings and execute all further documents, agreements and assurances as may be required from time to time in order to carry out the terms and conditions of this Agreement in accordance with their true intent.

IN WITNESS WHEREOF the parties hereto have executed this Amending Agreement as of the date and year first above written.
	
				
	 
	 
	ONCOLYTICS BIOTECH INC.

	Per:
	/s/ Wayne Pisano

	 
	 
	 
	 

	 
	 
	Per:
	/s/ Kirk Look

	 
	 
	 
	 

/S/ Floriane Riouall                    /S/ Matthew Coffey
___________________________        ________________________________
Witness                        MATTHEW COFFEYExhibit

AMENDING AGREEMENT #5
THIS AMENDING AGREEMENT made effective as of the 8 day of March, 2018.
BETWEEN:
ONCOYLYTICS BIOTECH INC.,
("ONCOLYTICS")
- and -
KIRK LOOK,
(the "Employee")
WHEREAS the Employee is an officer of Oncolytics whose terms of employment are set forth in the Executive Employment Agreement dated effective January 1, 2013, as amended by an Amending Agreement #1 dated March 12, 2014, Amending Agreement #2 dated March 12, 2015, Amending Agreement #3 dated March 8, 2016, and Amending Agreement #4 dated February 23, 2017 (together the "Employment Agreement");
AND WHEREAS Oncolytics and the Employee wish to amend the Employment Agreement;
NOW THEREFORE in consideration of the mutual covenants contained in this Amending Agreement, and other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, it is agreed as follows:
		
	1
	Interpretation

This Amending Agreement is supplemental to and shall form one agreement with the Employment Agreement, and the Employment Agreement and this Amending Agreement shall be read together and have effect so far as practicable as though all the provisions thereof and hereof were contained in one instrument.  In this Amending Agreement, including the recitals hereto, unless there is something within the subject matter or context inconsistent therewith, expressions herein, unless otherwise defined herein, have the same meanings as the corresponding expressions defined in the Employment Agreement.
		
	2
	Amendment to the Employment Agreement

The Employment Agreement Section 3 – Remuneration is amended as follows:
(1)Commencing January 1, 2018, Oncolytics shall pay to the Employee a salary of three hundred sixty-five thousand ($365,000) CANADIAN DOLLARS per annum, exclusive of bonuses, benefits and other compensation, payable in equal installments of fifteen thousand two hundred eight CANADIAN DOLLARS and thirty-three cents ($15,208.34) on the 15th and last day of each month.

		
	3
	Confirmation

The parties hereto hereby acknowledge and confirm that, except as specifically amended by the provisions of this Amending Agreement, all of the terms and conditions contained in the Employment Agreement are and shall remain in full force and effect, unamended, in accordance with the provisions thereof.
		
	4
	Miscellaneous

		
	(a)
	This Agreement shall be governed by and construed in accordance with the laws in force in the Province of Alberta.  The parties hereby submit to the jurisdiction of the Courts of Alberta.

		
	(b)
	The parties shall with reasonable diligence take all action, do all things, attend or cause their representatives to attend all meetings and execute all further documents, agreements and assurances as may be required from time to time in order to carry out the terms and conditions of this Agreement in accordance with their true intent.

IN WITNESS WHEREOF the parties hereto have executed this Amending Agreement as of the date and year first above written.
	
				
	 
	 
	ONCOLYTICS BIOTECH INC.

	Per:
	/s/ Wayne Pisano

	 
	 
	 
	 

	 
	 
	Per:
	/s/ Matt Coffey

	 
	 
	 
	 

/S/ Floriane Riouall                    /S/ Kirk Look
___________________________        ________________________________
Witness                        KIRK LOOKExhibit

AMENDING AGREEMENT #1
THIS AMENDING AGREEMENT made effective as of the 8th day of March, 2018.
BETWEEN:
ONCOYLYTICS BIOTECH (U.S.), INC.,
("OBUS")
- and -
ANDREW DE GUTTADAURO
(the "Employee")
WHEREAS the Employee is an officer of OBUS whose terms of employment are set forth in the Employment Agreement ("Employment Agreement") dated effective June 29, 2017;
AND WHEREAS OBUS and the Employee wish to amend the Employment Agreement;
NOW THEREFORE in consideration of the mutual covenants contained in this Amending Agreement, and other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, it is agreed as follows:
		
	1
	Interpretation

This Amending Agreement is supplemental to and shall form one agreement with the Employment Agreement, and the Employment Agreement and this Amending Agreement shall be read together and have effect so far as practicable as though all the provisions thereof and hereof were contained in one instrument.  In this Amending Agreement, including the recitals hereto, unless there is something within the subject matter or context inconsistent therewith, expressions herein, unless otherwise defined herein, have the same meanings as the corresponding expressions defined in the Employment Agreement.

		
	2
	Amendment to the Employment Agreement

The Employment Agreement Section 3 – Remuneration is amended as follows:

(1)    Commencing January 1, 2018, OBUS shall pay to the Employee a salary of two hundred fifty-three thousand ($253,000) UNITED STATES DOLLARS per annum, exclusive of bonuses, benefits and other compensation, payable in equal installments of ten thousand five hundred forty-one UNITED STATES DOLLARS and sixty-seven cents ($10,541.67) on the 15th and last day of each month

		
	3
	Confirmation

(1)    The parties confirm that the increase in Base Salary is a result of an assessment of increases in cost-of-living indices and salary benchmarking.

(2)    The parties hereto hereby acknowledge and confirm that, except as specifically amended by the provisions of this Amending Agreement, all of the terms and conditions contained in the Employment Agreement are and shall remain in full force and effect, unamended, in accordance with the provisions thereof.

		
	4
	Miscellaneous

		
	(a)
	This Agreement shall be governed by and construed in accordance with the laws of California.  

		
	(b)
	The parties shall with reasonable diligence take all action, do all things, attend or cause their representatives to attend all meetings and execute all further documents, agreements and assurances as may be required from time to time in order to carry out the terms and conditions of this Agreement in accordance with their true intent.

IN WITNESS WHEREOF the parties hereto have executed this Amending Agreement as of the date and year first above written.
   

	
				
	 
	 
	ONCOLYTICS BIOTECH (U.S.), INC.

	Per:
	/S/ Matt Coffey

	 
	 
	 
	Matt Coffey
Director

	 
	 
	Per:
	/S/ Gilles Gosselin

	 
	 
	 
	Gilles Gosselin
Director

/S/ Kirk Look                        /S/ Andrew de Guttadauro
___________________________        ________________________________
Witness                        ANDREW DE GUTTADAUROExhibit

AMENDING AGREEMENT #1
THIS AMENDING AGREEMENT made effective as of the 8th day of March, 2018.
BETWEEN:
ONCOYLYTICS BIOTECH (U.S.), INC.,
("OBUS")
- and -
ANDRES GUTIERREZ
(the "Employee")
WHEREAS the Employee is an officer of OBUS whose terms of employment are set forth in the Employment Agreement ("Employment Agreement") dated effective October 27, 2016;
AND WHEREAS OBUS and the Employee wish to amend the Employment Agreement;
NOW THEREFORE in consideration of the mutual covenants contained in this Amending Agreement, and other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, it is agreed as follows:
		
	1
	Interpretation

This Amending Agreement is supplemental to and shall form one agreement with the Employment Agreement, and the Employment Agreement and this Amending Agreement shall be read together and have effect so far as practicable as though all the provisions thereof and hereof were contained in one instrument.  In this Amending Agreement, including the recitals hereto, unless there is something within the subject matter or context inconsistent therewith, expressions herein, unless otherwise defined herein, have the same meanings as the corresponding expressions defined in the Employment Agreement.

		
	2
	Amendment to the Employment Agreement

The Employment Agreement Section 3 – Remuneration is amended as follows:

(1)    Commencing January 1, 2018, OBUS shall pay to the Employee a salary of three hundred thirty thousand ($330,000) UNITED STATES DOLLARS per annum, exclusive of bonuses, benefits and other compensation, payable in equal installments of thirteen thousand seven hundred fifty ($13,750) UNITED STATES DOLLARS on the 15th and last day of each month.

		
	3
	Confirmation

(1)    The parties confirm that the increase in Base Salary is a result of an assessment of increases in cost-of-living indices and salary benchmarking.

(2)    The parties hereto hereby acknowledge and confirm that, except as specifically amended by the provisions of this Amending Agreement, all of the terms and conditions contained in the Employment Agreement are and shall remain in full force and effect, unamended, in accordance with the provisions thereof.

		
	4
	Miscellaneous

		
	(a)
	This Agreement shall be governed by and construed in accordance with the laws of California.  

		
	(b)
	The parties shall with reasonable diligence take all action, do all things, attend or cause their representatives to attend all meetings and execute all further documents, agreements and assurances as may be required from time to time in order to carry out the terms and conditions of this Agreement in accordance with their true intent.

IN WITNESS WHEREOF the parties hereto have executed this Amending Agreement as of the date and year first above written.

	
				
	 
	 
	ONCOLYTICS BIOTECH (U.S.), INC.

	Per:
	/S/ Matt Coffey

	 
	 
	 
	Matt Coffey
Director

	 
	 
	Per:
	/S/ Gilles Gosselin

	 
	 
	 
	Gilles Gosselin
Director

/S/ Kirk Look                         /S/ Andres Gutierrez
___________________________        ________________________________
Witness                        ANDRES GUTIERREZ

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