Document:

EX-10.1

SECOND AMENDMENT AND WAIVER TO LOAN AND SECURITY AGREEMENT

THIS SECOND AMENDMENT AND WAIVER TO LOAN AND SECURITY AGREEMENT (this “Agreement”) is dated as
of July 31, 2013, by and among EPICEPT CORPORATION, a Delaware corporation (“EpiCept”), MAXIM
PHARMACEUTICALS INC., a Delaware corporation (“Maxim”), CYTOVIA, INC., a Delaware corporation
(“Cytovia”, and collectively with EpiCept and Maxim, the “Borrowers”), MIDCAP FUNDING III, LLC, a
Delaware limited liability company in its capacity as agent (“Agent”) for the lenders under the
Loan Agreement (as defined below) (“Lenders”), and the Lenders.

W I T N E S S E T H:

WHEREAS, Borrowers, Lenders and Agent are parties to that certain Loan and Security Agreement,
dated as of May 27, 2011, as amended by that certain First Amendment to Loan and Security
Agreement, dated as of August 27, 2012 (the “First Amendment”, and as such Loan and Security
Agreement may be further amended, restated, supplemented or otherwise modified from time to time,
the “Loan Agreement”; capitalized terms used herein have the meanings given to them in the Loan
Agreement except as otherwise expressly defined herein), pursuant to which Lenders have agreed to
provide to Borrowers certain loans and other extensions of credit in accordance with the terms and
conditions thereof; and

WHEREAS, the Borrowers have requested that the Agent and Lenders amend the Loan Agreement in
certain respects and the undersigned Lenders and the Agent are willing to make such amendment, all
in accordance with, and subject to, the terms and conditions set forth in, this Agreement.

NOW, THEREFORE, in consideration of the premises, the covenants and agreements contained
herein, and other good and valuable consideration, the receipt and adequacy of which are hereby
acknowledged, Borrowers, Lenders and Agent hereby agree as follows:

1. Acknowledgment of Obligations. Each Borrower acknowledges and agrees that as of
the Second Amendment Effective Date, but without giving effect to this Agreement, the aggregate
principal balance of the Term Loan is at least $4,070,967.80. The foregoing amount does not
include interest, fees, expense and other amounts that are chargeable or otherwise reimbursable
under the Loan Agreement and the other Loan Documents. Borrowers hereby acknowledge, confirm and
agree that all Term Loans made prior to the date hereof, together with interest accrued and
accruing thereon, and fees, costs, expenses and other charges owing by Borrowers to Agent and
Lenders under the Loan Agreement and the other Loan Documents, are unconditionally owing by
Borrowers to Agent and Lenders, without offset, defense or counterclaim of any kind, nature or
description whatsoever except as may be limited by applicable bankruptcy, insolvency,
reorganization, moratorium or other similar laws relating to or affecting creditor’s rights
generally.

2. Waiver of Existing Events of Default. Each Event of Default that has occurred
prior to the Second Amendment Effective Date of which Agent has prior knowledge is hereby waived.

3. Amendments to the Loan Agreement. Subject to the terms and conditions of this
Agreement, including without limitation fulfillment of the conditions to effectiveness specified in
Section 9 below, the Loan Agreement is hereby amended as follows:

(a) Section 2.2(b) of the Loan Agreement shall be deleted in its entirety and the following
revised Section 2.2(b) shall be substituted in lieu thereof:

“(b) Interest Payments and Repayment. Commencing on the first (1st)
Payment Date following the Funding Date of Tranche One, and continuing on the Payment Date
of each successive month thereafter through and including the Maturity Date, Borrower shall
make monthly payments of interest to each Lender in accordance with its respective Pro Rata
Share, in arrears, and calculated as set forth in Section 2.3. In addition to the interest
payments in accordance with the immediately preceding sentence, Borrower shall make
principal payments with respect to the Term Loans as follows: (i) commencing on the
Amortization Date, and continuing on the Payment Date of each successive month thereafter
through the First Amendment Effective Date, Borrower shall make consecutive monthly payments
of principal to each Lender in accordance with its respective Pro Rata Share, as calculated
by Agent based upon: (A) the amount of such Lender’s Term Loans and (B) a straight-line
amortization schedule ending on the Maturity Date, (ii) on the First Amendment Effective
Date, Borrower shall make a principal payment of $1,200,000, which payment shall be
allocated and paid to each Lender in accordance with its Pro Rata Share, (iii) on September
1, 2013, and on each Payment Date thereafter through the Maturity Date, Borrower shall make
principal payments of $277,419.35 on each such date, which payment shall be allocated and
paid to each Lender in accordance with its Pro Rata Share and (iv) Borrower shall pay the
remaining outstanding balance of the Term Loan on the Maturity Date. Without limiting the
foregoing, all unpaid principal and accrued interest with respect to the Term Loans is due
and payable in full on the Maturity Date. The Term Loans may be prepaid only in accordance
with Sections 2.2(c) and 2.2(d).”

(b) Section 14 of the Loan Agreement shall be amended by adding thereto in appropriate
alphabetical order the following definition:

“‘Second Amendment Effective Date’ means July 31, 2013.”

4. Final Payment Fee. Borrower acknowledges and agrees that, notwithstanding any of
the amendments or other modifications set forth herein or in any other documentation or
correspondence related to the Loan Agreement or Loan Documents, or any other action taken by
Borrower, Agent or any Lender, the Final Payment remains due and payable, in full and without
counterclaim or offset of any kind, on the Maturity Date.

5. Additional Covenants and Agreements. Until such time as Agent has indicated
otherwise in writing, Borrower agrees as follows:

(a) Pursuit and Approval of Acceptable Sale or Partnering Transaction.

(i) Borrower shall, and shall cause each of its agents, representatives, officers,
directors, employees and advisors, to use its best efforts to consummate an Acceptable Sale
or Partnering Transaction (as defined below) as soon as practical but in any event no later
than October 15, 2013. An “Acceptable Sale or Partnering Transaction” shall mean (i) a
sale, merger or similar transaction with respect to Borrower and/or (ii) a partnering
transaction in connection with the Borrower’s drug AmiKet (formerly known as EpiCept NP-1),
in the case of either or both clause (i) and (ii) on terms and conditions and subject to
documentation satisfactory to Agent in its sole discretion, which either (x) provides for
the payment in full of the Obligations by not later than October 15, 2013 or (y) provides
for the Loans and Loan Documents to remain outstanding on terms and conditions and pursuant
to documentation satisfactory to Agent in its sole discretion; provided,
that, nothing in this Agreement shall constitute Agent’s or any Lender’s consent to
any such transaction or any documentation entered into in connection with any such
transaction, all of which remains subject to future consent by Agent and the Lenders.

(ii) As of the Second Amendment Effective Date, the Specified Controlled Deposit
Account (as defined in the First Amendment) contains $539,948.25 (the “Designated Funds”).
Within three (3) Business Days of Agent’s receipt of evidence in form and substance
satisfactory to Agent that the Borrower has received the requisite shareholder approval
necessary to consummate an Acceptable Sale or Partnering Transaction, and so long as no new
Default or Event of Default has occurred or is continuing or Agent becomes aware of the
existence of an existing Event of Default that it was not previously aware of or notified
about, Agent shall transfer $269,974.13 of the Designated Funds (as defined in the First
Amendment) from the Specified Controlled Deposit Account to the Specified Controlled
Operating Account (as defined in the First Amendment).

(b) Budget Matters. Section 4 of the First Amendment is hereby modified by deleting
clause (c)(i)(C) of such section in its entirety and substituting in lieu thereof the following new
clause (c)(i)(C) to read in its entirety as follows:

“(C) at least three (3) Business Days prior to any request made by Borrower for a transfer
of the Specified Funds to the Specified Controlled Operating Account, deliver to Agent an
operating budget in form, substance and methodology satisfactory to Agent, which shall
reflect Borrower’s good faith projection of all cash receipts and disbursements on a
week-by-week basis in connection with the operation of its business through the next sixty
(60) days.”

(c) General Cooperation and Disclosure. Without limiting anything in clause (a) above
or otherwise in this Agreement, Borrower shall, and shall cause its officers, directors, employees
and advisors to, cooperate fully with Agent in furnishing information as and when reasonably
requested by Agent or any other Lender regarding the Collateral, Borrower’s financial affairs,
finances, financial condition, business and operations or any other matters related to the Borrower
or otherwise contemplated in this Agreement. Borrower authorizes Agent to meet and/or have
discussions with any of its officers, directors, employees and advisors from time to time as
reasonably requested by Agent to discuss any matters regarding the Collateral, Borrower’s or any
other Credit Party’s financial affairs, finances, financial condition, business and operations, or
any other matters related to the Borrower or otherwise contemplated in this Agreement and shall
direct and authorize all such persons and entities to fully disclose to Agent all information
reasonably requested by Agent regarding the foregoing. Borrower waives and releases any such
officer, director, employee and advisor from the operation and provisions of any confidentiality
agreement with Borrower, as the case may be, such that such person or entity is not prohibited from
providing any of the foregoing information to Agent or any Lender.

6. Additional Events of Default. Any of the following shall constitute an immediate
Event of Default hereunder and under the Loan Agreement: (a) the failure by Borrower to comply with
any term, condition or covenant set forth in this Agreement, (b) the failure of any representation
or warranty made by Borrower under or in connection with this Agreement to be true, correct and
complete as of the date when made or any other breach of any such representation or warranty, (c)
the repudiation and/or assertion of any defense by any Borrower with respect to this Agreement or
any Loan Document or the pursuit by Borrower or any person related to Borrower against the Agent or
any Indemnified Person, or (d) a determination by Agent in its sole discretion that (i)
discussions, negotiations or progress relating to any potential Acceptable Sale or Partnering
Transaction have ceased or slowed or other circumstances or developments have arisen that make it
unlikely that such sale or partnering transaction will be consummated or (ii) it is unlikely that
Borrower shall be able to document or consummate an Acceptable Sale or Partnering Transaction by
October 15, 2013.

7. No Other Amendments or Consents, Waivers, Etc.; Reservation of Rights. Except for
the amendments and other modifications set forth and referred to in Sections 2 thru
6 above, the Loan Agreement and the other Loan Documents shall remain unchanged and in full
force and effect. Nothing in this Agreement is intended, or shall be construed, to constitute a
novation or an accord and satisfaction of any of Borrowers’ Obligations or to modify, affect or
impair the perfection or continuity of Agent’s security interests in, security titles to or other
liens, for the benefit of itself and the Lenders, on any Collateral for the Obligations. Without
limiting the foregoing, except as expressly set forth herein, the execution, delivery and
effectiveness of this Agreement shall not directly or indirectly (i) create any obligation to make
any further loans, advances or other financial accommodations or to continue to defer any
enforcement action after the occurrence of any Default or Event of Default, whether such Default or
Event of Default has occurred or occurs in the future, (ii) constitute a consent or waiver of any
past, present or future violations of any provisions of the Loan Agreement or any other Loan
Documents nor constitute a novation of any of the Obligations under the Loan Agreement or other
Loan Documents, (iii) amend, modify or operate as a waiver of any provision of the Loan Agreement
or any other Loan Documents or any right, power or remedy of any Lender, (iv) constitute a consent
to any merger or other transaction or to any sale, restructuring or refinancing transaction or (v)
constitute a course of dealing or other basis for altering any Obligations or any other contract or
instrument. Except as expressly set forth herein, each Lender reserves all of its rights, powers,
and remedies under the Loan Agreement, the other Loan Documents and applicable law. All of the
provisions of the Loan Agreement and the other Loan Documents, including, without limitation, the
time of the essence provisions, are hereby reiterated, and if ever waived, are hereby reinstated.

8. Representations and Warranties. To induce Agent and Lenders to enter into this
Agreement, each Borrower does hereby warrant, represent and covenant to Agent and Lenders that (i)
each representation or warranty of Borrowers set forth in the Loan Agreement is hereby restated and
reaffirmed as true and correct in all material respects on and as of the date hereof as if such
representation or warranty were made on and as of the date hereof (except to the extent that any
such representation or warranty expressly relates to a prior specific date or period) and (ii) each
Borrower has the power and is duly authorized to enter into, deliver and perform this Agreement and
this Agreement is the legal, valid and binding obligation of each Borrower enforceable against such
Borrower in accordance with its terms.

9. Condition Precedent to Effectiveness of this Agreement. This Agreement shall
become effective as of July 31, 2013 (the “Second Amendment Effective Date”) upon which Agent shall
have received the following, each in form and, in form and substance satisfactory to Agent and
Lenders:

(a) one or more counterparts of this Agreement duly executed and delivered by Borrowers, Agent
and Lenders; and

(b) such other documents, instruments, agreements and opinions as the Agent shall request.

10. Release.

(a) In consideration of the agreements of Agent and Lenders contained herein and for other
good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, each
Borrower, on behalf of itself and its successors, assigns, and other legal representatives, hereby
absolutely, unconditionally and irrevocably releases, remises and forever discharges Agent and each
Lender and their respective successors and assigns, and their respective present and former
shareholders, affiliates, subsidiaries, divisions, predecessors, directors, officers, attorneys,
employees, agents and other representatives (Agent, Lenders and all such other persons being
hereinafter referred to collectively as the “Releasees” and individually as a “Releasee”), of and
from all demands, actions, causes of action, suits, covenants, contracts, controversies,
agreements, promises, sums of money, accounts, bills, reckonings, damages and any and all other
claims, counterclaims, defenses, rights of set-off, demands and liabilities whatsoever
(individually, a “Claim” and collectively, “Claims”) of every name and nature, known or unknown,
suspected or unsuspected, both at law and in equity, which any Borrower or any of its successors,
assigns, or other legal representatives may now or hereafter own, hold, have or claim to have
against the Releasees or any of them for, upon, or by reason of any circumstance, action, cause or
thing whatsoever which arises at any time on or prior to the Second Amendment Effective Date,
including, without limitation, for or on account of, or in relation to, or in any way in connection
with the Loan Agreement or any of the other Loan Documents or transactions thereunder or related
thereto.

(b) Each Borrower understands, acknowledges and agrees that its release set forth above may be
pleaded as a full and complete defense and may be used as a basis for an injunction against any
action, suit or other proceeding which may be instituted, prosecuted or attempted in breach of the
provisions of such release.

(c) Each Borrower agrees that no fact, event, circumstance, evidence or transaction which
could now be asserted or which may hereafter be discovered shall affect in any manner the final,
absolute and unconditional nature of the release set forth above.

11. Covenant Not To Sue. Each Borrower, on behalf of itself and its successors,
assigns, and other legal representatives, hereby absolutely, unconditionally and irrevocably,
covenants and agrees with and in favor of each Releasee that it will not sue (at law, in equity, in
any regulatory proceeding or otherwise) any Releasee on the basis of any Claim released, remised
and discharged by Borrowers pursuant to Section 10 above. If any Borrower or any of its
successors, assigns or other legal representatives violates the foregoing covenant, Borrowers, for
themselves and their successors, assigns and legal representatives, agree to pay, in addition to
such other damages as any Releasee may sustain as a result of such violation, all attorneys’ fees
and costs incurred by any Releasee as a result of such violation.

12. Indemnification. Borrower hereby agrees to indemnify, defend and hold harmless
Agent and each Lender in accordance with Section 12.2 of the Loan Agreement, the terms of which are
incorporated herein by reference.

13. Advice of Counsel. Each of the parties represents to each other party hereto that
it has discussed this Agreement with its counsel.

14. Severability of Provisions. In case any provision of or obligation under this
Agreement shall be invalid, illegal or unenforceable in any applicable jurisdiction, the validity,
legality and enforceability of the remaining provisions or obligations, or of such provision or
obligation in any other jurisdiction, shall not in any way be affected or impaired thereby.

15. Counterparts. This Agreement may be executed in multiple counterparts, each of
which shall be deemed to be an original and all of which when taken together shall constitute one
and the same instrument.

16. GOVERNING LAW. THIS AGREEMENT SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE
WITH, THE INTERNAL LAWS OF THE STATE OF MARYLAND APPLICABLE TO CONTRACTS MADE AND PERFORMED IN SUCH
STATE WITHOUT REGARD TO THE PRINCIPLES THEREOF REGARDING CONFLICTS OF LAWS.

17. Entire Agreement. The Loan Agreement and the other Loan Documents as and when
modified through this Agreement embody the entire agreement between the parties hereto relating to
the subject matter thereof and supersede all prior agreements, representations and understandings,
if any, relating to the subject matter thereof.

18. No Strict Construction, Etc. The parties hereto have participated jointly in the
negotiation and drafting of this Agreement. In the event an ambiguity or question of intent or
interpretation arises, this Agreement shall be construed as if drafted jointly by the parties
hereto and no presumption or burden of proof shall arise favoring or disfavoring any party by
virtue of the authorship of any provisions of this Agreement. Time is of the essence for this
Agreement.

19. Loan Document. For the avoidance of doubt, this Agreement constitutes a Loan
Document.

20. Costs and Expenses. Each Borrower absolutely and unconditionally agrees to pay or
reimburse upon demand for all reasonable fees, costs and expenses incurred by Agent and the Lenders
that are Lenders on the Closing Date in connection with the preparation, negotiation, execution and
delivery of this Agreement and any other Loan Documents or other agreements prepared, negotiated,
executed or delivered in connection with this Agreement or transactions contemplated hereby.

[Remainder of page intentionally blank; signature pages follow.]

IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be duly executed and
delivered as of the day and year specified at the beginning hereof.

BORROWERS:

EPICEPT CORPORATION

By:       

Name:       

Title:       

MAXIM PHARMACEUTICALS INC.

By:       

Name:       

Title:       

CYTOVIA, INC.

By:       

Name:       

Title:       

AGENT AND LENDER:

MIDCAP FUNDING III, LLC

By:       

Name:       

Title: Authorized SignatoryEX-10.1

EXHIBIT 10.1

Severance Agreement

1. This agreement is entered into by Cogent Communications, Inc. (“Cogent”) and the executive
employee signing this Agreement, below (“Executive”).

2. As an inducement for Executive to focus his or her full efforts on Cogent’s business
without undue concern for future employment the Compensation Committee of the Cogent Board of
Directors has approved the following minimum severance provisions for Executive.

3. If Executive is terminated other than for Cause (as defined below) or Executive terminates
his or her employment for Good Reason (as defined below), Executive shall continue to receive his
or her salary (reduced by all mandatory withholdings for taxes or other governmentally required
payments such as garnishments) for 3 months following the date of termination, i.e. Executive shall
be paid through the 91st day following the date of termination. Executive shall be paid commission
earned through Executive’s date of termination. However, if the termination follows a Change of
Control (as defined below) such payment shall be made as a lump sum within 5 days of termination.
Salary means Executive’s regular salary (excluding bonuses, income from vesting of restricted
stock, dividends paid on unvested and vested stock, and other similar elements of compensation that
are not regular salary) before voluntary withholdings and reductions (such as those for parking,
401(k) plan, medical, dental, and life insurance) and before mandatory withholdings for taxes and
other governmentally required payments such as garnishments. At the election of Executive, the
employee share of the cost of benefits (provided in paragraph 4) may be paid through a salary
reduction agreement (in order to make such payments with pre-tax income).

4. If Executive is terminated other than for Cause or Executive terminates his or her
employment for Good Reason, Executive shall continue to receive through the last day of the third
month following the month in which termination occurs health insurance, dental insurance, life
insurance (to the extent paid by the company), and long term disability insurance. Cogent shall
pay the company share of such benefits and Executive shall pay the employee share, e.g. the
employee portion of the premium for health and dental insurance. The employee share and company
share shall be the same as currently applicable to the benefits at the time of termination.

5. For purposes of this agreement, Cogent shall have “Cause” to terminate the Executive’s
employment hereunder (i) upon the Executive’s conviction for the commission of an act or acts
constituting a felony under the laws of the United States or any state thereof, or (ii) upon the
Executive’s willful and continued failure to substantially perform his or her duties hereunder
(other than any such failure resulting from the Executive’s incapacity due to physical or mental
illness), after written notice has been delivered to the Executive by Cogent, which notice
specifically identifies the manner in which the Executive has not substantially performed his
duties, and the Executive’s failure to substantially perform his duties is not cured within ten
(10) business days after notice of such failure has been given to the Executive. No act or failure
to act on the Executive’s part shall be deemed “willful” unless done or omitted to be done, by the
Executive not in good faith and without reasonable belief that the Executive’s act, or failure to
act, was in the best interest of Cogent.

6. “Good Reason” shall mean the occurrence (without the Executive’s express written consent)
of any one of the following:

	 	a.	 	the assignment to Executive of duties inconsistent with the
Executive’s status as a senior executive officer of the Company or a substantial
adverse alteration in the nature or status of the Executive’s responsibilities; or

	 	b.	 	a reduction in Executive’s regular salary; or

	 	c.	 	relocation of Executive’s principal place of employment outside of
the Washington, DC area.

7. “Change of Control” shall mean any of the following: (i) a consolidation, merger or
reorganization of Cogent Communications Group, Inc. with or into any other corporation or
corporations in which the stockholders of Cogent Communications Group, Inc. immediately before such
event shall own fifty percent (50%) or less (calculated on an as converted basis, fully diluted) of
the voting securities of the surviving corporation; (ii) a transaction or series of related
transactions, other than an underwritten public offering, in which at least fifty percent (50%) of
Cogent Communications Group, Inc.’s voting power is transferred; (iii) the sale, transfer or lease
of all or substantially all of the assets of Cogent Communications Group, Inc.; (iv) the
acquisition of shares of capital stock of Cogent Communications Group, Inc. (whether through a
direct issuance by Cogent Communications Group, Inc., negotiated stock purchase, a tender for such
shares, merger, consolidation or otherwise) by any party or group that did not beneficially own a
majority of the voting power of the outstanding shares of capital stock of Cogent Communications
Group, Inc. immediately prior to such purchase, the effect of which is that such party or group
beneficially owns at least a majority of such voting power immediately after such event; or (v) the
consummation by Cogent Communications Group, Inc. of a plan of complete liquidation of Cogent
Communications Group, Inc.

8. Executive’s continued employment shall not constitute consent to, or a waiver of rights
with respect to any act or failure to act constituting Good Reason hereunder. Notwithstanding the
foregoing, a termination shall not be treated as a Termination for Good Reason if the Executive
shall have consented in writing to the occurrence of the event giving rise to the claim of
Termination for Good Reason.

9. Executive shall be entitled to the indemnification set forth in the certificate of
organization of any entity for which he or she performs services to the maximum extent permitted by
law. Executive shall also be entitled to the protection of any insurance policies Cogent may elect
to maintain generally for the benefit of its directors and officers.

10. Executive agrees that he or she remains an employee at will whose employment may be
terminated at any time with or without cause.

11. Cogent agrees that Executive is giving consideration for this agreement by relying upon
its provisions in determining whether or not to seek other employment.

2

Accepted and agreed to:

	 	 	 	 	 	 	 
	 	 	Cogent Communications, Inc.

	 	 	 	Executive
	By:
	 	/s/Dave Schaeffer

	 	 	 	/s/ Ernest Ortega
	 	 	 

	 	 	 	 
	Name:
	 	Dave Schaeffer

	 	Name:
	 	Ernest Ortega
	Title:
	 	CEO

	 	Date:
	 	July 1, 2013
	Date:
	 	August 1, 2013

	 	

	 	

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