Document:

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                                                                  Attachments to
                                                                  Exhibit 10.4

Ex-10.4 Additional information to Business Loan Agreement among Genomic
        Solutions and certain of it's Warrantholders, dated October 28, 1999
<PAGE>   2
                                   EXHIBIT A

                                PROMISSORY NOTE

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THE RIGHTS OF THE HOLDER OF THIS NOTE TO RECEIVE PAYMENT ARE SUBJECT AND
SUBORDINATE TO THE PAYMENT OF ALL OBLIGATIONS OF MAKER OR OBLIGOR TO COMERICA
BANK, AND ITS SUCCESSORS AND ASSIGNS, UNDER THE TERMS OF THE SUBORDINATION
AGREEMENT DATED OCTOBER 28, 1999 EXECUTED BY GENOMIC SOLUTIONS, INC., THE PAYEE
OF THIS NOTE, ET AL.

THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933 OR
ANY STATE SECURITIES LAWS. THEY MAY NOT BE SOLD OR OFFERED FOR SALE, PLEDGED,
HYPOTHECATED OR OTHERWISE TRANSFERRED IN THE ABSENCE OF AN EFFECTIVE
REGISTRATION STATEMENT AS TO THE SECURITIES UNDER SAID ACT AND ANY APPLICABLE
STATE SECURITIES LAW OR UNLESS THE COMPANY HAS RECEIVED AN OPINION OF COUNSEL
SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED TO EFFECTUATE
SUCH TRANSACTION.

                           P R O M I S S O R Y  N O T E

$                                                            Ann Arbor, Michigan
                                                             October 28, 1999

     FOR VALUE RECEIVED, Genomic Solutions, Inc., a Delaware corporation, 4355
Varsity Drive, Suite E, Ann Arbor, Michigan 48108, Genomic Solutions, Ltd., a
United Kingdom corporation, Unit 3, Forge Close, Little End Road, Eaton Socon,
St. Neots, Cambridgeshire, England PE193TP and Genomic Solutions, K.K., a
Japanese corporation, Gotanda Chuo Bldg. 2F, 3-5, Higashigotanda 2-chome,
Shinagawa-ku, Tokyo 141-0022, Japan, jointly and severally, hereinafter
collectively referred to as "Borrower", promise to pay to the order of       ,
hereinafter called the "Lender," or holder the sum of      ($     ) dollars in
lawful money of the United States of America, with interest at the rate of
percent (12.0%) per annum on all sums at any time unpaid, at    or at such
other place as the holder hereof may designate by written notice to the
Borrower, with interest from the date of the disbursement of the loan, until
paid.

     The principal and interest shall be payable over five (5) years ("Loan
Term") as follows: except as otherwise provided herein for early payment, the
principal shall be due and payable on the earliest of (i) October 28, 2004, (ii)
the settlement date following the effective date of a registration statement
filed by Genomic Solutions, Inc. (hereinafter sometimes referred to as "Parent")
with the Securities and Exchange Commission for a public offering and sale of
securities of Parent, (iii) the effective date, immediately after the effective
time, of any merger or consolidation of Parent, (iv) a transfer of more than

<PAGE>   4

50% of the issued and outstanding common stock of Parent (if immediately after
the transfer the transferee has control of Parent), or (v) a sale of
substantially all of the assets of Parent. Interest shall be payable quarterly
in arrears on each March 31, June 30, September 30 and December 31 commencing
December 31, 1999. On each interest payment date, (i) 7/12ths of the interest
payable on such date shall be paid in cash, and (ii) 5/12ths of the interest
payable on such date shall be paid by the issuance to Lender of a number of
shares of common stock of Parent equal to the amount of such interest divided by
the Minimum Company Value, provided that on each scheduled interest payment
date, Lender may upon ten (10) days' prior written notice to Parent elect not to
receive such payment in shares of common stock of Parent and instead elect to
defer payment of 5/12ths of the interest due on such scheduled interest payment
date, which amount shall then be added to the outstanding principal balance of
this Note with effect as of such payment date. Except as otherwise provided
herein for early or accelerated payment, the entire unpaid principal balance
plus accrued interest and all other indebtedness shall be due and payable on or
before October 28, 2004. Interest shall be calculated on a 365 day basis on the
unpaid principal balance for the actual days outstanding. For purposes of the
foregoing, "Minimum Company Value" shall be the same amount determined as the
Minimum Company Value in accordance with the provisions of the Warrants attached
to the Loan Agreement (defined below) as Exhibit B (initially $4.50 per share).

     Parent has granted to Lender a security interest in or lien upon all assets
of Parent as described in the Security Agreement and Assignment and Pledge
Agreement of even date herewith, and Borrower may hereafter grant a security
interest in or lien upon other assets as may be described in any other security
agreement, mortgage, or other document executed at any time by the Borrower and
delivered to the Lender (herein collectively termed "Collateral") as security
for the payment of this Note, and for the payment of all other liabilities,
whether direct, indirect, absolute or contingent, now or hereafter existing, due
to become due, several or otherwise, of the Borrower to the Lender under the
Loan Documents (as defined in the Loan Agreement) (herein termed
"Indebtedness").

     Upon an event of default under any security agreement, the Business Loan
Agreement dated October 28, 1999 between Lender, Borrower and others (the "Loan
Agreement"), or any document given in connection with the Collateral, which
event of default is not cured within any applicable grace period, (i) this Note
and all Indebtedness shall, at the option of the Lender, become immediately due
and payable in full without notice, presentation or demand for payment, all such
being hereby waived by the Borrower and in such event, it is agreed that the
Lender may exercise all rights and remedies available to it under any security
agreement, hypothecation agreement, Loan Agreement, or other agreement relating
to or otherwise securing any of the

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Indebtedness or, which may be available to Lender under the Uniform Commercial
Code as in effect in the State of Michigan or other applicable law, and (ii)
this Note shall thereafter bear interest at the rate of sixteen percent (16%)
per annum until such default is cured. Delay or forbearance by the Lender in the
exercise of any right granted hereunder shall not operate as a waiver thereof.

     A late payment fee in the amount of five percent (5.0%) of the installment
due and owing will be assessed against the Borrower in the event the payment
required hereunder is received by the Lender more than ten (10) days after the
due date.

     Provided that all interest payments on this Note shall then be current,
Borrower may prepay this Note in whole at any time or in part from time to time.
Upon any payment of the principal of this Note in whole or in part prior to
October  , 2004, including as a result of this Note becoming immediately due and
payable at the option of the Lender in accordance with the terms of this Note,
Borrower shall pay a premium equal to the following sums:

     (i) on amounts prepaid prior to October 29, 2000 - five percent (5%) of
amounts prepaid;

     (ii) on amounts prepaid after October 28, 2000 but prior to October 29,
2001, four percent (4%) of amounts prepaid;

     (iii) on amounts prepaid after October 28, 2001 but prior to October 29,
2002, three percent (3%) of amounts prepaid;

     (iv) on amounts prepaid after October 28, 2002 but prior to October 29,
2003, two percent (2%) of amounts prepaid;

     (v) on amounts prepaid after October 28, 2003, one percent (1%) of amounts
prepaid,

provided however that (x) if such payment of this Note is a condition imposed by
parties purchasing not less than $10,000,000 of common stock or preferred stock
of Parent, the premium payable upon payment of this Note in whole or in part
prior to October 29, 2000 shall be 2-1/2% instead of 5%, and (y) no premium
shall be payable if the value of Borrower, implicit in the price at which shares
of common stock of Parent are sold in a public offering pursuant to a
registration statement, or the price applicable in any merger or consolidation
of Parent or the transfer of more than 50% of the issued and outstanding common
stock of Parent or the sale of substantially all of the assets of Parent, shall
exceed $50,000,000, and if the prepayment of this Note shall occur by reason of
such event. This Note is one of various promissory notes executed and delivered
by Borrower pursuant to the Loan Agreement. Borrower shall not prepay this Note
in whole or in part unless Borrower shall concurrently prepay in whole or a
prorata part of all other promissory notes

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originally executed and delivered by Borrower on the same date as this Note.

     Notwithstanding any provision to the contrary, it is the intent of the
Lender and Borrower that neither the Lender nor any subsequent holder shall be
entitled to receive, collect, reserve or apply, as interest, any amount in
excess of the maximum lawful rate of interest permitted to be charged by
applicable law or regulations, as amended or enacted from time to time. In the
event the Note calls for an interest payment that exceeds the maximum lawful
rate of interest then applicable, such interest shall not be received,
collected, charged, or reserved until such time as that interest, together with
all other interest then payable, falls within the applicable maximum lawful rate
of interest. In the event the Lender, or any subsequent holder, receives any
such interest in excess of the then maximum lawful rate of interest, such amount
which would be excessive interest shall be deemed a partial prepayment of
principal and treated hereunder as such, or, if the principal indebtedness
evidenced hereby is paid in full, any remaining excess funds shall immediately
be paid to the Borrower.

     Borrower hereby waives presentment, demand, protest and notice of dishonor
and agrees that Borrower shall not be released or discharged by reason of any
release, sale or non-action with respect to the Collateral or other undertakings
securing this Note.

     The security rights of Lender and its assigns shall not be impaired by
Lender's sale, hypothecation, or rehypothecation of any Note of the Borrower or
any item of the Collateral, or by any indulgence, including but not limited to:
(i) Any renewal, extension, or modification which Lender may grant with respect
to the Indebtedness or any part thereof, (ii) Any surrender, compromise,
release, renewal, extension, exchange, or substitution which Lender may grant in
respect to the Collateral, or (iii) any indulgence granted in respect of any
endorser, co-maker, guarantor or surety. The purchaser, assignee, transferee, or
pledgee of this Note, the Collateral, any guarantee, and any other document (or
any of them), sold, assigned, transferred, pledged, or repledged, shall
forthwith become vested with and entitled to exercise all the powers and rights
given by this Note and all Loan Documents of the undersigned to Lender, as if
said purchaser, assignee, transferee, or pledgee were originally named as payee
in this Note and in the Loan Documents.

     This Note shall be construed, interpreted and enforced in accordance with
the laws of the State of Michigan without regard to its conflict of laws
principles. Borrower expressly submits to the jurisdiction and venue in the
Federal or state courts of the State of Michigan by process served by mail on
Borrower at the address set forth above.

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     This Note has been negotiated between Borrower and Lender and shall be
deemed to be mutually drafted by them.

     IN WITNESS WHEREOF, this Note has been executed by the duly authorized
officers of the Borrower.

                                        GENOMIC SOLUTIONS, INC.

                                        By:
                                           -------------------------------------
                                           Jeffrey S. Williams, President

                                        GENOMIC SOLUTIONS, LTD

                                        By:
                                           -------------------------------------
                                        GENOMIC SOLUTIONS, K.K.

                                        By:
                                           -------------------------------------

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                                 EXHIBIT B has
                                 been filed as
                          Exhibit 4.13, 4.14 and 4.15

<PAGE>   9

                                   EXHIBIT C

                               SECURITY AGREEMENT

<PAGE>   10

                               SECURITY AGREEMENT

     This Security Agreement is entered into this 28th day of October, 1999, by
Genomic Solutions, Inc., a Delaware corporation, 4355 Varsity Drive, Suite E,
Ann Arbor, Michigan 48108 ("Borrower") in favor of White Pines Limited
Partnership I, a Michigan limited partnership, 2401 Plymouth Road, Suite B, Ann
Arbor, Michigan 48105 (hereinafter referred to as "WPLP"), Pacific Capital,
L.P., a Delaware limited partnership, 2401 Plymouth Road, Suite B, Ann Arbor,
Michigan 48105 (hereinafter referred to as "Pacific"), Chase Venture Capital
Associates, L.P., a California limited partnership, 380 Madison Avenue, 12th
Floor, New York, New York 10017 (hereinafter referred to as "Chase"), American
Healthcare Fund II, a Delaware limited partnership, 4430 Arapahoe Avenue, Suite
220, Boulder, Colorado 80303 (hereinafter referred to as "American"), Ian R. N.
Bund, 2401 Plymouth Road, Suite B, Ann Arbor, Michigan 48105 (hereinafter
referred to as "Bund"), Yocum Consulting Associates, Inc., an Ohio corporation,
4622 Wyndwood Drive, Toledo, Ohio 43623 (hereinafter referred to as "Yocum"),
Volunteer Healthcare Associates, L.L.C., a Tennessee limited liability company,
6 Cadillac Drive, Suite 310, Brentwood, Tennessee 37027 (hereinafter referred to
as "Volunteer"), J. Matthew Mackowski, 275 Post Street, Suite 600, San
Francisco, California 94108 (hereinafter referred to as "Mackowski-CA"), Robert
G. Shepler, 275 Post Street, Suite 600, San Francisco, California 94108
(hereinafter referred to as "Shepler"), John J. Mackowski, 1506 Birkdale Lane,
Ponte Verde Beach, Florida 32082 (hereinafter referred to as "Mackowski-FL"),
Grove Investment Partners, an Illinois partnership, 336 Essex Road, Kenilworth,
Illinois 60043 (hereinafter referred to as "Grove") Ronald G. Kalish Living
Trust u/a/d September 9, 1997, 445 Grand Bay Drive, #1009, Key Biscayne, Florida
33149 (hereinafter referred to as "Kalish"), McDonald Investments Inc.
Custodian FBO Daniel J. Boyle IRA Rollover Account #85314893, 2550 Som Center
Road, Suite 300, Willoughby Hills, Ohio 44094 (hereinafter referred to as
"Boyle"), Kantner and Associates Profit Sharing Plan u/a/d January 1, 1991, 661
Airport Blvd., Suite 2A, Ann Arbor, Michigan 48108 (hereinafter referred to as
"Kantner"), Michael G. Williams, 18000 Cavanaugh Lake Road, Chelsea, Michigan
48118 (hereinafter referred to as "Williams"), Lawrence J. Kent, 404 E.
Lancaster Ave., Wayne, Pennsylvania 19087 (hereinafter referred to as "Kent"),
Jeffrey S. Williams, 7049 Suncrest Drive, Saline, Michigan 48176 (hereinafter
referred to as "JWilliams"), Kevin A. Auton, 42 Croftfield Road, Godmanchester,
Huntingdon, Cambridgeshire PE18 8ED (hereinafter referred to as "Auton"), Andrew
A. Jakimcius, 1096 Heritage Drive, Saline, Michigan 48176 (hereinafter
"Jakimcius"), Michael P. Kurek, 2720 Holyoke Lane, Ann Arbor, Michigan 48103
(hereinafter referred to as "Kurek") and Steven J. Richvalsky, 12215 Deer Creek
Circle, Plymouth, Michigan 48170 (hereinafter referred to as "Richvalsky")
(WPLP, Pacific, Chase, American, Bund, Yocum, Volunteer, Mackowski-CA, Shepler,
Mackowski-FL, Grove, Kalish, Boyle, Kantner, Williams, Kent, JWilliams, Auton,
Jakimcius, Kurek and Richvalsky each

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being sometimes hereinafter referred to as "Lender", a "Lender" or the "Lender"
and collectively as "Lenders").

     For value received, the Borrower hereby grants to each Lender a security
interest in and to all of the Borrower's tangible and intangible real and
personal property and fixtures, whether now owned or hereafter acquired,
including, but not limited to, goods, documents, inventory, work in process,
instruments, equipment, furniture, machinery, fixtures, trade fixtures, contract
rights, chattel paper, accounts receivable, documents, patents, licenses and
motor vehicles, together with the proceeds from the sale or other disposition
thereof and the products thereof (the "Collateral"). The Collateral shall be
considered to be all of the assets of the Borrower. The Borrower hereby pledges,
assigns, transfers and grants to the Lender a security interest in the
Collateral to secure the payment of all loans, advances, and extensions of
credit from the Lender to the Borrower, including all renewals and extensions
thereof and any and all obligations of every kind whatsoever, whether now, or
hereafter existing or arising between the Lender and the Borrower and howsoever
incurred or evidenced, whether primary, secondary, contingent, or otherwise,
under or in connection with (1) the Borrower's Notes of even date herewith in
the aggregate amount of three million five hundred thousand and no/100
($3,500,000) dollars to the Lenders, payable as to principal and interest as
provided in the Notes; (2) future advances by the Lender to the Borrower, if
any, pursuant to Section 1(c) of the Business Loan Agreement of even date
herewith; (3) all costs and expenditures made or incurred by the Lender for
taxes, insurance, and repairs to and maintenance of the Collateral or made or
incurred by Lender in the disbursement, administration, collection or
enforcement of the Notes; and (4) all liabilities of Borrower to Lender now
existing or incurred in the future, matured or unmatured, direct or contingent,
and any renewals, extensions, and substitutions of those liabilities, and any
other obligations of the Borrower, under the Business Loan Agreement and Loan
Documents (as defined therein) of Borrower of even date herewith. The foregoing
obligations shall be hereafter collectively called the "liabilities" and shall
also include all interest, costs, expenses, and reasonable actual attorneys fees
accruing to or incurred by the Lender.

     The Borrower hereby warrants, covenants and agrees as follows:

     1.  Warranties. The Borrower warrants the following:

        (a) except as provided in the Business Loan Agreement, it has or will
acquire free and clear title to all of the Collateral and the security interest
granted to Lender shall be a first security interest, and the Borrower will
defend same to the Lender against the claims and demands of all persons;

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             (b) the Borrower will fully cooperate in placing or maintaining
Lender's lien or security interest;

             (c) all of the collateral is located in the states of Michigan or
Massachusetts;

             (d) all accounts are genuine and collectible except to the extent
of reserves provided on the balance sheet;

             (e) the Borrower will not remove or change the location of any
Collateral without the Lender's prior written consent;

             (f) the Borrower will not use the Collateral or permit it to be
used for any unlawful purpose;

             (g) the Borrower will not conduct business under any name other
than that stated herein, nor change, nor reorganize the type of business entity
as described, except upon the prior written approval of the Lender, in which
event the Borrower agrees to execute any documentation of whatsoever character
or nature demanded by the Lender for filing or recording, at the Borrower's
expense, before such change occurs;

             (h) the Borrower will keep all records of account, documents,
evidence of title, and all other documentation regarding its business and the
Collateral at the address specified herein, unless notice thereof is given to
the Lender at least ten (10) days prior to the change of any address for the
keeping of such records; the Borrower will, at all times, maintain the
Collateral in good condition and repair, ordinary wear and tear excepted, and
will not sell or remove same except as to inventory in the ordinary course of
business;

             (i) the Borrower is a legally created business entity, as described
before, and it has the power, and the person signing is duly authorized, to
enter into this Agreement; the execution of this Agreement will not create any
breach of any provision of any other agreement to which Borrower is a party; and

             (j) all Financial Statements delivered by the Borrower to the
Lender to obtain loans and extensions of credit taken as a whole (A) fairly
present in all material respects (subject, in the case of the interim financial
statements, to normal, recurring year-end adjustments which are not material
individually or in the aggregate) the financial position of the Borrower as of
the dates indicated and the results of operations of the Borrower for the
periods indicated, (B) (x) have been prepared in accordance with Generally
Accepted Accounting Principles ("GAAP") consistently applied throughout the
periods covered thereby (subject, in the case of the interim financial
statements, to normal, recurring year-end adjustments which are not material
individually or in the aggregate) or (y) to the

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extent not prepared in accordance with GAAP, then footnotes to the Financial
Statements will be provided describing in reasonable detail the differences, if
any, between the accounting principles pursuant to which such Financial
Statements were in fact prepared and GAAP and (C) are in accordance with the
books and records of the Borrower which have been maintained in a manner
consistent with historical practice.

             2. Insurance. Borrower shall maintain adequate fire and extended
risk coverage, business interruption, workers disability compensation, public
liability, environmental, flood, and such other insurance coverages as may be
required by law or as is customary and adequate among businesses in Borrowers'
industry engaged in the same or similar activities. All insurance policies shall
be in such amounts, upon such terms, in form, and carried with insurers with a
"best rating" of B or better or such insurers as are acceptable to Lender. Each
Borrower shall provide evidence satisfactory to Lender of all insurance
coverages and that the policies are in full force and effect, and for all
insurance coverages upon any property which is collateral, the insurance policy
shall be endorsed to provide Lender with a standard loss payable clause with not
less than thirty (30) days advance written notice to Lender by the insurer of
any cancellation or modification of coverage. Said proceeds may be utilized to
restore or replace the collateral with Lender's consent, which consent will not
be unreasonably withheld, provided Borrower is not in default other than a
default arising from the loss of or damage to collateral. In the event of
default or if said proceeds are not utilized to restore or replace the
collateral, Lender may apply such proceeds as it may receive toward the payment
of the liabilities in such order as the Lender may at its sole discretion
determine. If the Borrower at any time fails to obtain or to maintain any of
the insurance required above or pay any premium in whole or in part relating
thereto, the Lender, without waiving any default hereunder, may make such
payment or obtain such policies as the Lender, in its sole discretion, deems
advisable to protect the Borrower's property. All costs incurred by the Lender,
including reasonable attorney's fees, court costs, expenses, and other charges
thereby incurred, shall become a part of the liabilities and shall be payable on
demand.

             3. Taxes, Liens, etc. The Borrower agrees to pay all taxes, levies,
judgments, assessments, and charges of any nature whatsoever relating to the
Collateral or to the Borrower's business. Except to the extent that Borrower
has established a cash reserve and is actively pursuing a tax appeal, if the
Borrower fails to pay such taxes or other charges in accordance with the
foregoing, the Lender at its sole discretion, may pay such charges on behalf of
the Borrower; and all sums so dispensed by the Lender, including reasonable
actual attorney's fees, court costs, expenses, and other charges relating
thereto, shall become a part of the liabilities and shall be payable on demand.

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             4.  Information and Reporting. The Borrower agrees to supply to the
Lender such information concerning the status of any of its assets as the
Lender, from time to time, may reasonably request. The Borrower further agrees
to permit the Lender, its employees, and agents to have access to the Collateral
for the purpose of inspecting it, together with all of the Borrower's other
physical assets if any, and to permit the Lender, from time to time, to verify
accounts as well as to inspect, copy, and to examine the books, records, and
files of the Borrower.

             5.  Accounts. The Borrower acknowledges that Lender has a security
interest in Accounts. It is understood that the Lender will initially permit the
Borrower to collect accounts from its debtors. The Borrower understands that
this privilege may be terminated by the Lender only after an event of default
under the Business Loan Agreement or the Notes, Warrants or this Agreement shall
occur and is not cured within any applicable grace period, and that, in such
event:

                 (a) the Lender shall be vested with all of the rights of the
Borrower in respect thereto, including the right of stoppage in transit, the
ability to notify any debtor or debtors of the assignment, and the ability to
execute any instrument on behalf of the Borrower in settlement or fulfillment of
an account;

                 (b) the Borrower agrees to execute such assignments as the
Lender may request to evidence the assignment and, in the event of an assignment
to the Lender, Borrower thereafter receives payment on any account as the agent
of the Lender, and the Borrower agrees to transmit such payment in the form in
which it was received to the Lender on the date of receipt thereof,
appropriately endorsed, if necessary, to permit negotiation by the Lender;

                 (c) until such remittance, the Borrower agrees to keep all such
receipts on account separate and apart from the Borrower's own funds so that
such receipts are readily identifiable as the property of the Lender and to hold
same in trust for the Lender; and

                 (d) in any event, the Lender is authorized to endorse or to
sign, in the name of the borrower, any instrument of whatsoever nature to effect
the collection of the accounts for application to the liabilities.

             6. Default. A default by the Borrower under the Business Loan
Agreement, the Notes, the Warrants or any other agreement entered into between
the Borrower and the Lender, which default is not cured within any applicable
grace period, shall constitute a default of this Security Agreement. The
covenants, conditions, events of default and other terms set forth or referred
to in any and all documents entered into between the

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Borrower and Lender are incorporated into this Security Agreement with the same
force and effect as if those such covenants, conditions, and events of default
were fully set forth herein.

             7. Remedy.  The Borrower agrees that, whenever a default exists,
Lender shall have the remedies set forth in the Business Loan Agreement and
Lender may exercise, from time to time, any rights and remedies, including the
right to immediate possession of the Collateral, available to it under
applicable law. The lender shall have the right to hold any property then in or
upon said Collateral at the time of repossession not covered by the security
agreement until return is demanded in writing by the Borrower or other party
entitled thereto. The Borrower agrees, in the case of default, to assemble, at
its own expense, all Collateral at a convenient place acceptable to the Lender
and to pay all reasonable costs of the Lender in connection with the collecting
of the liabilities and enforcement of any rights hereunder, including reasonable
attorney's fees and legal expenses, and including participation in Bankruptcy
proceedings; and to pay all of the expense of locating the collateral, as well
as the expense of any repairs for any realty or other property to which any of
the Collateral may have been affixed or made a part. Any notification of
intended disposition of the Collateral by the Lender shall be deemed to be
reasonable and proper if sent postage prepaid, by regular mail, to the Borrower
at least seven (7) days before such disposition, and addressed to the Borrower
either at the address shown herein or at any other address. The Lender shall, in
the event of any default have the right to peacefully retake any of the goods.
In the event of a default, the Borrower expressly authorizes the Lender to
offset any debts of the Lender to the Borrower against the Liabilities.

             8. Termination.  This Agreement and related financing statements
shall be terminated upon payment in full of the aforementioned Notes and all
other sums and expenses required to be paid pursuant to the terms of the
Business Loan Agreement, the Loan Documents other than the Warrants, and the
Warrants but only if prior to the time such termination would otherwise occur
Borrower has been notified of the exercise of Lenders' rights under subsection
(K) of the Warrants. If this Agreement and the related financing statements
shall have been terminated prior to the date on which Borrower is notified of
the exercise of Lenders' rights under subsection (K) of the Warrants, the
effectiveness of this Agreement shall automatically continue or be reinstated
with respect to all amounts payable in accordance with the terms of the Warrants
upon notice to Borrower of the exercise of Lenders' rights under subsection (K)
of the Warrants.

             9. Miscellaneous. Time is of the essence of this agreement.  Except
as otherwise defined in this agreement, all terms herein shall have the meanings
provided by the Uniform Commercial Code as it has been adopted in the State of
Michigan. Any delay on the part of the Lender in exercising any power,

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privilege, or right hereunder, or under any other document executed by the
Borrower to the Lender in connection herewith, shall not operate as a waiver
thereof, and no single or partial exercise thereof or any other power,
privilege, or right shall preclude other or further exercise thereof. The waiver
by the Lender of any default of the Borrower shall not constitute a waiver of
subsequent default. All rights, remedies, and powers of the Lender hereunder are
irrevocable and cumulative, and not alternative or exclusive, and shall be in
addition to all rights, remedies, and powers given hereunder or in or by any
other instruments or by the provision of the Uniform Commercial Code as adopted
in the State of Michigan, or any other laws now existing or hereinafter enacted.

             This agreement has been delivered in the State of Michigan and
shall be construed in accordance with the laws of the State of Michigan.
Whenever possible, each provision of this agreement shall be interpreted in such
manner as to be effective and valid under applicable law; but, if any provision
of this agreement shall be prohibited by or invalid under applicable law, such
provision shall be ineffective to the extent of such provision or the invalidity
without invalidating the remainder of such provision or the remaining provisions
of this agreement. The rights and privileges of the Lender hereunder shall inure
to the benefits of its successors and assigns, and this agreement shall be
binding on all successors and assigns of the Borrower. The Borrower may not
assign this agreement or any benefits accruing to it hereunder without the
express written consent of the Lender.

             This agreement has been negotiated between Borrower and Lender and
shall be deemed to be mutually drafted by them.

             In witness whereof, the parties have executed this Agreement on the
date and year first above written.

LENDERS:                                     BORROWERS:

WHITE PINES LIMITED PARTNERSHIP I            GENOMIC SOLUTIONS, INC.
By: White Pines G.P., L.L.C.,
    its general partner

By:                                          By:
   ---------------------------------            -------------------------------
   Frederick L. Yocum, Chairman                 Jeffrey S. Williams
                                                President

PACIFIC CAPITAL, L.P.                        GENOMIC SOLUTIONS, LTD.
By: WP Pacific G.P., L.L.C.
    a general partner

By:                                          By:
   ---------------------------------            -------------------------------
   Frederick L. Yocum, Chairman

                                       7

<PAGE>   17

IAN R. N. BUND                               GENOMIC SOLUTIONS, K.K.

YOCUM CONSULTING ASSOCIATES, INC.
VOLUNTEER HEALTHCARE ASSOCIATES, L.L.C
RONALD G. KALISH LIVING TRUST U/A/D          By:
   SEPTEMBER 9, 1997                            -------------------------------
McDONALD INVESTMENTS INC. CUSTODIAN
   FBO DANIEL J. BOYLE IRA ROLLOVER
   ACCOUNT #85314893
KANTNER AND ASSOCIATES PROFIT SHARING
   PLAN U/A/D JANUARY 1, 1991
MICHAEL G. WILLIAMS

By:  White Pines Management, L.L.C.,
     a Michigan limited liability
     company, attorney-in-fact

By:
   ---------------------------------
   Frederick L. Yocum, Chairman

CHASE VENTURE CAPITAL ASSOCIATES, L.P.

By:
   ---------------------------------
AMERICAN HEALTHCARE FUND II

By:
   ---------------------------------

------------------------------------
J. MATTHEW MACKOWSKI

------------------------------------
ROBERT G. SHEPLER

------------------------------------
JOHN J. MACKOWSKI

GROVE INVESTMENT PARTNERS

By:
   ---------------------------------

------------------------------------
LAWRENCE J. KENT

------------------------------------
JEFFREY S. WILLIAMS

------------------------------------
KEVIN A. AUTON

                                       8

<PAGE>   18

------------------------------------
ANDREW A. JAKIMCIUS

------------------------------------
MICHAEL P. KUREK

------------------------------------
STEVEN J. RICHVALSKY

                                       9

<PAGE>   19

                                   EXHIBIT D

                            SUBORDINATION AGREEMENT

<PAGE>   20

                             SUBORDINATION AGREEMENT
                          (All Indebtedness and Liens)

Genomic Solutions, Inc., Genomic Solutions, Ltd., and Genomic Solutions K.K.
(each, a "Borrower" and, together the "Borrowers") are indebted to the
undersigned (each a "Creditor" and collectively "Creditors") in the aggregate
principal sum of three Million five hundred thousand Dollars ($3,500,000)
evidenced by [ ] AN OPEN ACCOUNT [x] PROMISSORY NOTES [ ] OTHER (DESCRIBE) ____
___________ which indebtedness is [ ] UNSECURED [x] SECURED by substantially all
assets of the Borrowers, and Creditors are or may become financially interested
in Borrowers and desire to aid Borrowers in obtaining or having continued
financial accommodations, whether by way of loan, commitment to loan,
discounting of instruments, extensions of credit or the obtaining of any other
financial aid from Comerica Bank ("Bank").

In order to induce the Bank to extend or to continue to extend financial
accommodations to Borrowers from time to time, whether by way of a loan,
commitment to loan, discounting of instruments, extension of credit or otherwise
and in consideration of any of these financial accommodations, Bank, Borrowers
and Creditors agree as follows:

1.   Any and all obligations and liabilities of Borrowers to Creditors,
     including, without limit, principal and interest payments, whether direct
     or indirect, absolute or contingent, joint or several, secured or
     unsecured, due or to become due, now existing or later arising and whatever
     the amount and however evidenced (the "Subordinated Indebtedness"), are
     subordinated in right of payment to any and all obligations and liabilities
     of Borrowers to the Bank, including, without limit, principal and interest
     payments, whether direct or indirect, absolute or contingent, joint or
     several, secured or unsecured, due or to become due, now existing or later
     arising and however evidenced, together with all other sums due thereon and
     all costs of collecting the same (including, without limit, reasonable
     attorney fees) for which Borrowers are liable (the "Senior Indebtedness")
     provided, however, that Senior Indebtedness does not include aggregate
     principal amounts at any one time outstanding in excess of $3,000,000
     during 1999, in excess of $6,000,000 during 2000, in excess of $7,000,000
     during 2001 or in excess of $8,000,000 during 2002 or thereafter.

2.   Except as otherwise provided in this agreement, Creditors will not ask for,
     demand, sue for, take or receive (by way of voluntary payment,
     acceleration, set-off or counterclaim, foreclosure or other realization on
     security, dividends in bankruptcy or otherwise), or offer to make any
     discharge or release of, any of the Subordinated Indebtedness, and
     Creditors
<PAGE>   21
     waive any such rights with respect to the Subordinated Indebtedness nor
     shall Creditors exercise any rights of subrogation or other similar rights
     with respect to the Senior Indebtedness,

3.   Subject to the provisions of Subsection 20(B) below, Creditors will not
     exercise any of Creditors' rights in any collateral now or later securing
     the Subordinated Indebtedness. All rights of Creditors in any collateral
     now or later securing the Subordinated Indebtedness are subordinated to all
     rights of the Bank now or later existing in any of the same collateral
     securing the Senior Indebtedness.

4.   The Bank, in its own name or in the name of Creditors, may collect and
     enforce the Subordinated Indebtedness and all claims and demands of
     Creditors in connection therewith, by proof of debt in bankruptcy, or in
     any other proceeding involving dissolution, insolvency, liquidation or an
     adjustment of the indebtedness of Borrower. Creditors make, constitute and
     appoint Bank their true and lawful attorney-in-fact with full power of
     substitution to take any action in furtherance of the foregoing in the
     event Creditors fail to do so promptly following request by Bank,
     including, but not limited to, the signing of proofs of claim, evidence
     of indebtedness, and the execution and delivery of all documents and
     agreements necessary to obtain or accomplish any protection for or
     collection or disposition of any part of the Subordinated Indebtedness or
     any collateral. Such appointment shall be deemed irrevocable and coupled
     with an interest.

5.   Should any payment, distribution or security or proceeds from these be
     received by Creditors upon or with respect to the Subordinated Indebtedness
     contrary to the terms of this Agreement, Creditors shall immediately
     deliver same to the Bank in the form received (except for endorsement or
     assignment by Creditors where required by the Bank), for application on
     the Senior Indebtedness (whether or not then due and in such order of
     maturity as Bank elects) and, until so delivered, the same shall be held in
     trust by Creditors as the property of the Bank.

6.   Each Creditor represents and warrants severally but not jointly that it has
     not made or permitted to be made any assignment, transfer, pledge, or
     disposition for collateral purposes or otherwise, of all or any part of the
     Subordinated Indebtedness or any collateral or other security for the
     Subordinated Indebtedness. The Creditors agree that any instrument or
     document evidencing the Subordinated Indebtedness shall at all times bear
     the following legend:

     The rights of the holder of this Note to receive payment are subject and
     subordinate to the payment of all obligations of maker or obligor to
     Comerica Bank, and its successors and assigns, under the terms of the
     Subordination Agreement dated October  , 1999 executed by Genomic
     Solutions, Inc., the payee of this note, et al.

7.   This Agreement constitutes a continuing agreement of subordination, even
     though at times Borrowers are not indebted to the Bank. The Bank may
     continue, in reliance on this Agreement, without notice to Creditors, to
     lend monies, extend credit, modify, renew or

                                       2

<PAGE>   22

     make other financial accommodations, to or for the account of Borrowers
     until the fourteenth (14th) day ("effective date") following delivery by
     Creditors to Bank of revocation of this Agreement. Any such notice of
     revocation shall not be effective as to any Senior Indebtedness existing at
     the effective date of revocation or any Senior Indebtedness created after
     that pursuant to any commitment or agreement of the Bank or pursuant to
     any Borrower loan (whether advances or readvances by the Bank after the
     effective date of revocation are optional or obligatory) existing at the
     effective date of revocation or any modifications or renewals of any such
     Senior Indebtedness, whether in whole or in part. Possession by the Bank of
     any note or other evidence of indebtedness made, endorsed or guaranteed by
     Borrower shall be conclusive evidence (but not the only means of
     establishing) that Borrower is indebted to the Bank.

8.   (INTENTIONALLY OMITTED]

9.   Each Creditor delivers this Agreement based solely on its independent
     investigation of (or decision not to investigate) the financial condition
     of Borrowers and is not relying on any information furnished by the Bank.
     Each Creditor assumes full responsibility for obtaining any further
     information concerning Borrowers' financial condition, the status of the
     Senior Indebtedness or any other matter which it may deem necessary or
     appropriate now or later. Each Creditor waives any duty on the part of the
     Bank, and agrees that it is not relying upon nor expecting the Bank to
     disclose to it any fact now or later known by the Bank, whether relating to
     the operations or condition of Borrowers, the existence, liabilities or
     financial condition of any guarantor of the Senior Indebtedness, the
     occurrence of any default with respect to the Senior Indebtedness, or
     otherwise, notwithstanding any effect such fact may have upon Creditor's
     risk or Creditor's rights against any Borrower. Each Creditor knowingly
     accepts the full range of risk encompassed in this Agreement, which risk
     includes, without limit, the possibility that Borrowers may incur Senior
     Indebtedness to the Bank after the financial condition of Borrowers, or its
     ability to pay Borrowers' debts as they mature, has deteriorated. Each
     Creditor acknowledges and agrees that the Bank's rights under this
     Agreement are not conditioned upon pursuit by the Bank of any remedy the
     Bank may have against Borrowers or any other person or any other security.

10.  The Bank, in its sole discretion, without notice to Creditors, may release
     or exchange any security now or later held by the Bank for payment of the
     Senior Indebtedness or release any party now or later liable for payment of
     the Senior Indebtedness without affecting in any manner the Bank's rights
     under this Agreement. Each Creditor acknowledges and agrees that the Bank
     has no obligation to acquire or perfect any lien on or security interest in
     any asset(s), whether realty or personalty, to secure payment of the Senior
     Indebtedness, and that it is not relying upon assets in which the Bank has
     or may have a lien or security interest for payment of the Senior
     Indebtedness.

11.  Notwithstanding any prior revocation, termination surrender, or discharge
     of this Agreement in whole or in part, the effectiveness of this Agreement
     shall automatically continue or be reinstated in the event that any payment
     received or credit given by the Bank in respect of the Senior Indebtedness
     is returned, disgorged, or rescinded under any applicable state or

                                       3
<PAGE>   23
     federal law, including, without limitation, laws pertaining to bankruptcy
     or insolvency, in which case this Agreement, shall be enforceable against
     each Creditor as if the returned, disgorged, or rescinded payment or credit
     had not been received or given by the Bank, and whether or not the Bank
     relied upon this payment or credit or changed its position as a consequence
     of it. In the event of continuation or reinstatement of this Agreement,
     each Creditor agrees upon demand by the Bank to execute and deliver to the
     Bank those documents which the Bank determines are appropriate to further
     evidence (in the public records or otherwise) this continuation or
     reinstatement, although the failure of the Creditor to do so shall not
     affect in any way the reinstatement or continuation.

12.  Each Creditor waives any right to require the Bank to: (a) proceed against
     any person or property; or (b) pursue any other remedy in the Bank's power.
     Each Creditor waives notice of acceptance of this Agreement and
     presentment, demand, protest, notice of protest, dishonor, notice of
     dishonor, notice of default, notice of intent to accelerate or demand
     payment of any Senior Indebtedness, and diligence in collecting any Senior
     Indebtedness, and agrees that the Bank may, once or any number of times,
     modify the terms of any Senior Indebtedness, compromise extend, increase,
     accelerate, renew or forbear to enforce payment of any or all Senior
     Indebtedness, or permit any Borrower to incur additional Senior
     Indebtedness, all without notice to Creditors and without affecting in any
     manner the unconditional obligations of Creditors under this Agreement.

13.  Each Creditor acknowledges that the Bank has the right to sell, assign,
     transfer, negotiate or grant participations or any interest in, any or all
     of the Senior Indebtedness and any related obligations, including without
     limit this Agreement. In connection with the above, but without limiting
     its ability to make other disclosures to the full extent allowable, the
     Bank, may disclose all documents and information which the Bank now or
     later has or acquires relating to Creditor and this Agreement, however
     obtained. Creditor further agrees that the Bank may disclose such documents
     and information to Borrowers. Each Creditor further agrees that the Bank
     may provide information relating to this Agreement or relating to Creditors
     to the Bank's parent, affiliates, subsidiaries and service providers.

14.  No waiver or modification of any rights under this Agreement shall be
     effective unless the waiver or modification shall be in writing and signed
     by an authorized officer of the applicable party. Each waiver or
     modification shall be a waiver or modification only with respect to the
     specific matter to which the waiver or modification relates and shall in no
     way impair the rights of the party or the Obligations of the other parties
     in any other respect.

15.  This Agreement shall bind and be for the benefit of Creditors and the Bank
     and their respective successors and assigns, and shall be construed
     according to the laws of the State of Michigan, without regard to conflict
     of laws principles. If this Agreement is executed by two or more persons,
     it shall bind each of them individually as well as jointly.

16.  The term "Borrower", as used in this Agreement, includes any person,
     corporation, partnership or other entity which succeeds to the interests or
     business of a Borrower named above, and the terms "Senior Indebtedness" and
     "Subordinated Indebtedness" include

                                       4
<PAGE>   24

     indebtedness of any successor Borrower to the Bank and Creditors.
     Reference to the Borrower' indebtedness in this Agreement refers to
     indebtedness of any one or more Borrowers.

17.  Creditors jointly and not severally agree to reimburse the Bank upon
     demand for any and all costs and expenses (including, without limit, court
     costs, legal fees, and reasonable attorney fees whether inside or outside
     counsel is used, whether or not suit is instituted and, if instituted,
     whether at the trial or appellate level, in a bankruptcy, probate or
     administrative proceeding, or otherwise) incurred in enforcing the duties
     and obligations of Creditors under Section 4 of this Agreement.

18.  Each Creditor waives any defense against the enforceability of this
     Agreement based upon or arising by reason of the application by any
     Borrower of the proceeds of any Indebtedness for purposes other than the
     purposes represented by any Borrower to the Bank or intended or understood
     by the Bank or Creditors. Each Creditor waives all rights to require the
     Bank to marshall the Collateral or any other property the Bank may at any
     time have as security for the Indebtedness and waives all right to require
     the Bank to first proceed against any guarantor or other person before
     proceeding against the Collateral.

19.  The relative priorities of the Bank and Creditors in the Collateral as set
     forth in this Agreement control irrespective of the time, method or order
     of attachment or perfection of the liens and security interests acquired by
     the parties in the Collateral and irrespective of the priorities as would
     otherwise be determined by reference to the Uniform Commercial Code or
     other applicable laws. Creditors shall not contest die validity, priority
     or perfection of the Bank's security interest in the Collateral (regardless
     of whether the Bank's security interest in the Collateral is valid or
     perfected). The priorities of any liens or security interests of the
     parties in any property of the Borrowers other than the Collateral are not
     affected by this Agreement and shall be determined by reference to
     applicable law. The Bank's rights under this Agreement are in addition to,
     and not in substitution of, its rights under any other subordination
     agreement with any Creditor.

20.  Special Provisions:

     A.   Notwithstanding anything to the contrary in this Agreement, Creditors
          may ask for, demand, sue for, take or receive from Borrowers the
          regularly scheduled quarterly payments which may come due under the
          above-described promissory notes ("Notes") and expense reimbursements
          permitted thereunder; provided, however, that Creditors may not ask
          for, demand, sue for, take or receive from Borrower any such payments
          after Creditors are given written notice by the Bank that a default or
          an event of default exists or has occurred under any note(s),
          guaranty(ies), and/or agreement(s) between the Bank and Borrower or
          that any loan(s) between Borrower and the Bank has (have) been called
          (a "Standstill Notice"). All such payments due Creditors under the
          Notes must be suspended until such time (if ever) as Creditor receives
          subsequent written notice from the Bank stating that the default has
          been cured and/or the loan(s) has (have) been paid. The Bank agrees to
          give Borrower

                                       5
<PAGE>   25

          copies of the notices, but the Bank's failure to do so shall not
          affect its rights under this Agreement or any other agreement with
          Borrower. The Notes may not be modified or prepaid without the prior
          written consent of the Bank.

     B.   Notwithstanding any of the other provisions of this Agreement, if
          within 120 days after receipt by Creditors of a Standstill Notice the
          Bank has not accelerated the Senior Indebtedness and initiated legal
          action against Borrowers or the Collateral, and continued to
          diligently pursue such legal action and/or remedies, Creditors may
          accelerate the due date of the Notes, may demand and sue for the
          amounts due under the Notes and exercise any of Creditors' rights in
          any Collateral now or later securing the Subordinated Indebtedness
          regardless of the issuance of a subsequent Standstill Notice.
          Creditors shall give the Bank written notice of their intent to so
          exercise their remedies ten days prior to exercising such remedies. In
          exercising remedies against the collateral, the Creditors shall
          cooperate with the Bank and shall remit any proceeds of the sale or
          disposition of collateral to the Bank to be applied to the Senior
          Indebtedness until such time as the Senior Indebtedness is paid in
          full. In no event shall a Standstill Notice arising from default other
          than a payment default be in effect without the commencement of legal
          action by the Bank as provided in this paragraph for more than 120
          days in any 12 month period.

     C.   In the event of any distribution, division or application, whether
          partial or complete, voluntary or involuntary, by operation of law or
          otherwise, of all or any part of Borrowers' assets, or the proceeds of
          Borrowers' assets, in whatever form, to Creditors of Borrower or upon
          any indebtedness of Borrowers, whether by reason of the liquidation,
          dissolution or other winding-up of Borrowers, or by reason of any
          execution sale, receivership, insolvency, or bankruptcy proceeding,
          assignment for the benefit of Creditors, proceedings for
          reorganization, or readjustment of Borrowers or Borrowers' properties,
          then and in such event, (a) the Senior Indebtedness shall be paid in
          full before any payment is made upon the Subordinated Indebtedness,
          and (b) all payments and distributions, of any kind or character and
          whether in case, property, or securities, which shall be payable or
          deliverable upon or respect of the Subordinated Indebtedness shall
          be paid or delivered directly to Bank for application in payment of
          the amounts then due on the Senior Indebtedness until the Senior
          Indebtedness shall have been paid in full.

     D.   Upon payment in full of the Senior Indebtedness, Creditor shall be
          subrogated to any rights, liens and security interests of Bank
          pursuant to the Senior Indebtedness.

     E.   This agreement may be executed in any number of counterparts, each of
          which shall constitute an original and all of which taken together
          shall constitute one and the same agreement.

     F.   The parties acknowledge and agree that Bank is holding original stock
          certificates of Genomic Solutions, Ltd. and Genomic Solution, K.K. as
          security for the Senior Indebtedness and that Bank will not release
          those stock certificates without first

                                       6
<PAGE>   26

          giving Creditors the opportunity to take possession of those
          certificates to perfect their security interest in those stock
          certificates as security for the Subordinated Indebtedness.

6.   This Agreement is in addition to and not substitution for the Subordination
     Agreement dated as of April 23, 1999 among certain of the Creditors and the
     Bank.

THE UNDERSIGNED AND THE BANK ACKNOWLEDGE THAT THE RIGHT TO TRIAL BY JURY IS A
CONSTITUTIONAL ONE, BUT THAT IT MAY BE WAIVED. EACH PARTY, AFTER CONSULTING (OR
HAVING HAD THE OPPORTUNITY TO CONSULT) WITH COUNSEL OF THEIR CHOICE, KNOWINGLY
AND VOLUNTARILY, AND FOR THEIR MUTUAL BENEFIT, WAIVES ANY RIGHT TO TRIAL BY JURY
IN THE EVENT OF LITIGATION REGARDING THE PERFORMANCE OR ENFORCEMENT OF, OR IN
ANY WAY RELATED TO, THIS AGREEMENT.

                                       7
<PAGE>   27

IN WITNESS WHEREOF, Creditors and Bank have caused this Agreement to be executed
as of October    , 1999.

CREDITORS:

WHITE PINES LIMITED PARTNERSHIP I

By:  White Pines G.P., L.L.C.,
     its general partner

By:
   ------------------------------------
      Frederick L. Yocum, Chairman

PACIFIC CAPITAL, L.P.
By:  WP Pacific  G.P.,  L.L.C.
     a general partner

BY:
   ------------------------------------
      Frederick L. Yocum, Chairman

IAN R. N. BUND
YOCUM CONSULTING ASSOCIATES, INC.
VOLUNTEER HEALTHCARE ASSOCIATES, L.L.C.
RONALD G. KALISH LIVING TRUST U/A/D
          SEPTEMBER 9, 1997

MCDONALD INVESTMENTS INC. CUSTODIAN
FBO DANIEL J. BOYLE IRA  ROLLOVER
ACCOUNT #85314893

                                       8
<PAGE>   28

KANTNER AND ASSOCIATES PROFIT SHARING
         PLAN U/A/D JANUARY 1, 1991
MICHAEL G. WILLIAMS

By:    White Pines Management, L.L.C.
       a Michigan limited liability company,
       attorney-in fact

By:
   ------------------------------------
       Frederick L. Yocum, Chairman

CHASE VENTURE CAPITAL ASSOCIATES, L.P.

By:
   ------------------------------------

AMERICAN HEALTHCARE FUND II

By:
   ------------------------------------

---------------------------------------
J. MATTHEW MACKOWSKI

---------------------------------------
ROBERT G. SHEPLER

---------------------------------------
JOHN J. MACKOWSKI

GROVE INVESTMENT PARTNERS

By:
   ------------------------------------

---------------------------------------
LARRY KENT

                                       9
<PAGE>   29

---------------------------------------
JEFFREY S. WILLIAMS

---------------------------------------
KEVIN A. AUTON

---------------------------------------
ANDREW A. JAKIMCIUS

---------------------------------------
MICHAEL P. KUREK

---------------------------------------
STEVEN J. RICHVALSKI

                                       10
<PAGE>   30

COMERICA BANK                       BANK'S ADDRESS:

By:                                 500 Woodward Avenue
   --------------------------       Detroit, MI 48226

Its:
    -------------------------

                            BORROWER'S ACKNOWLEDGMENT

The undersigned ("Borrowers") accept notice of the subordination created by this
Agreement and agree that they will take no action inconsistent with this
Agreement. Borrowers agree that the Bank may, at its option, without notice and
without limiting Bank's other rights, upon any breach by Creditors holding at
least 10% of the aggregate outstanding principal amount of the Subordinated
Indebtedness ("Material Creditors") of, or purported termination by Material
Creditors of, this Agreement, declare all Senior Indebtedness to be immediately
due and payable and/or terminate any commitments of Bank to Borrowers.

GENOMIC SOLUTIONS, INC.                              BORROWERS' ADDRESS

By:
   -----------------------------                     4355 Varsity Drive
          Jeffrey S. Williams                        Ann Arbor, MI 48108
Its:      President

GENOMIC SOLUTIONS, LTD

By:
   -----------------------------
Its:
    ----------------------------

GENOMIC SOLUTIONS, K.K.

By:
   -----------------------------
Its:
    ----------------------------

                                       11
<PAGE>   31
                                   EXHIBIT E

                               BORROWER'S OPINION

<PAGE>   32

                                    EXHIBIT F

                AMENDMENT NO. 1 TO REGISTRATION RIGHTS AGREEMENT

                              FILED AS EXHIBIT 4.7

<PAGE>   33

                                   EXHIBIT G

                             SHAREHOLDER AGREEMENT

<PAGE>   34

                                   EXHIBIT H

                        ASSIGNMENT AND PLEDGE AGREEMENT

<PAGE>   35

                         ASSIGNMENT AND PLEDGE AGREEMENT

     1.   Genomic Solutions, Inc., a Delaware corporation, 4355 Varsity Drive,
Suite E, Ann Arbor, Michigan 48108 (herein "Pledgor"), in consideration of
financial accommodations given, or to be given, or continued to Pledgor, Genomic
Solutions, Ltd., a United Kingdom corporation, Unit 3, Forge Close, Little End
Road, Eaton Socon, St. Neots, Cambridgshire, England PE193TP and/or Genomic
Solutions, K.K., a Japanese corporation, Gotanda Chuo Bldg. 2F, 3-5,
Higashigotanda 2-chome, Shinagawa-ku, Tokyo 141-0022, Japan (Genomic Solutions,
Ltd. and Genomic Solutions, K.K. each sometimes hereinafter being referred to as
a "Subsidiary" and sometimes hereinafter collectively referred to as the
"Subsidiaries" and each of Pledgor, Genomic Solutions, Ltd. and Genomic
Solutions, K.K. sometimes hereinafter referred to as "Borrower", a "Borrower" or
the "Borrower" and collectively sometimes referred to as the "Borrowers") by
White Pines Limited Partnership I, a Michigan limited partnership, 2401 Plymouth
Road, Suite B, Ann Arbor, Michigan 48105 (hereinafter referred to as "WPLP"),
Pacific Capital, L.P., a Delaware limited partnership, 2401 Plymouth Road,
Suite B, Ann Arbor, Michigan 48105 (hereinafter referred to as "Pacific"), Chase
Venture Capital Associates, L.P., a California limited partnership, 380 Madison
Avenue, 12th Floor, New York, New York 10017 (hereinafter referred to as
"Chase"), American Healthcare Fund II, a Delaware limited partnership, 4430
Arapahoe Avenue, Suite 220, Boulder, Colorado 80303 (hereinafter referred to as
"American"), Ian R. N. Bund, 2401 Plymouth Road, Suite B, Ann Arbor, Michigan
48105 (hereinafter referred to as "Bund"), Yocum Consulting Associates, Inc., an
Ohio corporation, 4622 Wyndwood Drive, Toledo, Ohio 43623 (hereinafter referred
to as "Yocum"), Volunteer Healthcare Associates, L.L.C., a Tennessee limited
liability company, 6 Cadillac Drive, Suite 310, Brentwood, Tennessee 37027
(hereinafter referred to as "Volunteer"), J. Matthew Mackowski, 275 Post Street,
Suite 600, San Francisco, California 94108 (hereinafter referred to as
"Mackowski-CA"), Robert G. Shepler, 275 Post Street, Suite 600, San Francisco,
California 94108 (hereinafter referred to as "Shepler"), John J. Mackowski,
1506 Birkdale Lane, Ponte Verde Beach, Florida 32082 (hereinafter referred to as
"Mackowski-FL"), Grove Investment Partners, an Illinois partnership, 336 Essex
Road, Kenilworth, Illinois 60043 (hereinafter referred to as "Grove") Ronald G.
Kalish Living Trust u/a/d September 9, 1997, 445 Grand Bay Drive, #1009, Key
Biscayne, Florida 33149 (hereinafter referred to as "Kalish"), McDonald
Investments Inc. Custodian FBO Daniel J. Boyle IRA Rollover Account #85314893,
2550 Som Center Road, Suite 300, Willoughby Hills, Ohio 44094 (hereinafter
referred to as "Boyle"), Kantner and Associates Profit Sharing Plan u/a/d
January 1, 1991, 661 Airport Blvd., Suite 2A, Ann Arbor, Michigan 48108
(hereinafter referred to as "Kantner"), Michael G. Williams, 18000 Cavanaugh
Lake Road, Chelsea, Michigan 48118 (hereinafter referred to as "Williams"),
Lawrence J. Kent, 404 E. Lancaster Ave., Wayne, Pennsylvania 19087 (hereinafter
referred to as "Kent"), Jeffrey S. Williams, 7049 Suncrest Drive, Saline,

                                       1
<PAGE>   36
Michigan 48176 (hereinafter referred to as "JWilliams"), Kevin A. Auton, 42
Croftfield Road, Godmanchester, Huntingdon, Cambridgeshire PE18 8ED (hereinafter
referred to as "Auton"), Andrew A. Jakimcius, 1096 Heritage Drive, Saline,
Michigan 48176 (hereinafter "Jakimcius"), Michael P. Kurek, 2720 Holyoke Lane,
Ann Arbor, Michigan 48103 (hereinafter referred to as "Kurek") and Steven J.
Richvalsky, 12215 Deer Creek Circle, Plymouth, Michigan 48170 (hereinafter
referred to as "Richvalsky") (WPLP, Pacific, Chase, American, Bund, Yocum,
Volunteer, Mackowski-CA, Shepler, Mackowski-FL, Grove, Kalish, Boyle, Kantner,
Williams, Kent, JWilliams, Auton, Jakimcius, Kurek and Richvalsky each being
sometimes hereinafter referred to as "Lender", a "Lender" or the "Lender" and
collectively as "Lenders"), and as collateral security for the payment of all
debts, obligations or liabilities now or hereafter existing, absolute or
contingent, including any extensions or renewals thereof, present or future,
direct or indirect, due or to become due from the Borrowers to the Lenders under
(i) the Promissory Notes in the amount of three million five hundred thousand
and no/100 ($3,500,000) dollars, (ii) the Business Loan Agreement of even date
herewith between Borrowers and Lenders, and (iii) all obligations due under any
of the Loan Documents (as defined in the Business Loan Agreement), (all of which
shall be called "Indebtedness"), hereby irrevocably assigns, orders, transfers,
pledges and sets over to Lenders, their successors and assigns:

          (a)  All distributions, profit distributions, proceeds from sale of
stock included in the Collateral, and any and all other distributions due to
Pledgor from each Subsidiary and any successor in interest thereto.

          (b)  All shares and other property delivered to and deposited with the
Lenders, all property which is hereafter delivered to or comes into the
possession or control of the Lenders in any manner and for any purpose during
the existence of this Agreement, together with the stock rights, rights to
subscribe, liquidating dividends, stock dividends, dividends paid in stock, new
securities or other property which the Pledgor is entitled to receive and grants
to Lenders a continuing security interest in certain instruments, stock, chattel
paper, notes, debentures or other securities, to wit:

All shares of and 100% of its ownership interest in each Subsidiary as well
as any and all other property now or hereafter in the Lenders' possession or
control (all of the above set forth in subparagraph 1(a) and 1(b) herein
collectively termed "Collateral").

     2.   Pledgor warrants:

          (a)  that it is the lawful owner of all the Collateral including one
hundred percent (100%) of the capital stocks of each Subsidiary free of all
claims, liens, or encumbrances

                                       2
<PAGE>   37
whatsoever other than as set forth in the Business Loan Agreement and the
security interest granted to Lenders pursuant hereto;

          (b)  all written information furnished by Pledgor to Lenders
hereafter, will be correct and true as of the date given; and

          (c)  that the pledge and security interest in the Collateral arising
out of this Agreement has been given and granted to induce the Lenders to
extend, or to continue to extend, credit accommodations to the Borrowers.

     3.   At any time, after an event of default under the Business Loan
Agreement or the Promissory Notes, Warrants or Security Agreement contemplated
therein shall occur and is not cured within any applicable grace period and
without notice, and at the expense of the Pledgor, Lenders may but are not
obligated to:

          (a) collect all dividends, interest, principal payments and other sums
payable upon or on account of the Collateral;

          (b) Enter into an extension, reorganization, deposit, merger or
consolidation agreement, or other agreement related to or affecting the
Collateral, and in this connection may deposit or surrender control of the
Collateral, accept other property in exchange for the Collateral, and perform
such acts and things as it considers proper. Money or property received in
exchange for the Collateral shall be applied to the Indebtedness secured hereby;

          (c) compromise or settle claims or disputes as it deems desirable or
proper with reference to the Collateral;

          (d)  Insure, process and preserve the Collateral;

          (e)  Transfer the title to the Collateral to its name or the name of
the nominee;

          (f)  Exercise as to the Collateral, all the rights, powers and
remedies of an owner; and

          (g) Perform any and all acts which Lenders in good faith deem
necessary for the protection and preservation of Collateral or its value or
Lenders' security interest therein, including, but not limited to, transferring
any Collateral to Lenders' own name and receiving the income thereon as
additional security hereunder.

     4.   If, during the term of this Agreement, any stock dividends,
reclassifications, adjustments or other changes are made in the capital
structure of the corporation or other entity issuing the Collateral or any
portion thereof, whether it is a

                                       3
<PAGE>   38

reorganization, recapitalization, share split-up, a combination of shares,
merger, transfer, or consolidation, all new, additional or substituted shares
for securities of whatever class, issued with respect to the Collateral by
reason of change, shall be delivered to the Lenders immediately after issuance.
The Lenders shall hold the shares or security so issued as the Collateral under
the terms of this Agreement. If, during the term of this Agreement, warrants,
options, or other rights with respect to the Collateral are issued to the
Pledgor, and if the Pledgor exercises any such warrants, option, or right, all
new stock or securities received upon such exercise shall be delivered by the
Pledgor to the Lenders immediately after they are issued. Such new stock or
securities shall be held by the Lenders as Collateral under the terms of the
Agreement.

     5.   (a) At any time after a default shall occur in any of the Indebtedness
according to the terms thereof, which default is not cured within any applicable
grace period, including the Notes, Security Agreements, Business Loan Agreement,
Warrants, or any other Loan Document between Lenders and Borrowers and/or the
Pledgor (the terms of such being incorporated by reference herein); including a
material impairment in any way of the value of the Collateral or Lender's rights
therein, the Lender may at its option, without notice or demand to Pledgor,
declare all or part of the Indebtedness to be immediately due and payable. The
Lender shall have the remedies of a secured party under the Uniform Commercial
Code of the State of Michigan. The Lenders may sell the Collateral in such
manner and for such price as the Lenders deem appropriate without any liability
for any loss due to decrease in the market value of the Collateral during the
period held. The Lender shall have the right to purchase all or part of the
Collateral at public or private sale. If notification of intended disposition of
any of the Collateral is required by law, such notification shall he deemed
reasonable and properly given if mailed, postage prepaid, at least seven (7)
days before any such disposition to any address of the Pledgor appearing on the
records of the Lenders. Lenders shall have the right, but shall not be
obligated, to vote the Collateral.

          (b) Upon the exercise of Lenders' rights to receive distributions with
respect to the Collateral as provided in Section 3 above, Lenders shall be
vested with all the rights of the Pledgor in respect thereto, the ability to
notify any obligor or payor of the assignment and the ability to execute any
instrument on behalf of the Pledgor in settlement or fulfillment thereof. In
such event, Pledgor agrees to execute such additional assignments, instruments
and documents as the Lenders may request to evidence the assignment. The Pledgor
agrees that if thereafter it receives any payment of any such sums it shall
receive same as the agent of the Lenders and the Pledgor agrees to transmit such
payment in the form in which it was received to the Lenders on the date of
receipt thereof, appropriately endorsed, if necessary, to permit negotiation by
the Lenders. In any event, the Lenders are authorized to endorse or to sign, in

                                       4
<PAGE>   39

the name of the Pledgor, any instrument of whatsoever nature to effect the
collection of said payments for application to all sums due the Lenders.

     6.   The Collateral shall be evidenced by share certificates registered in
the name of Pledgor and accompanied by stock powers duly executed in blank. Said
share certificates and duly executed stock powers have been delivered to Lenders
concurrently with the execution of this Agreement

     7.   The proceeds of any sale shall be applied in the following order:

          (a)  to pay all costs and expenses of every kind for care,
safekeeping, collection, sale, foreclosure, delivery or otherwise respecting the
Collateral (including reasonable expenses incurred in the protection of the
Lenders' title or lien upon or right in any of the Collateral, reasonable actual
expenses for legal services of any kind in connection therewith or making of
such sale or sales, insurance, commission for sale, or guaranty).

          (b)  to interest on all Indebtedness of the Borrowers to the Lenders;

          (c)  to principal thereof, whether or not such Indebtedness is due or
accrued. After such application, Lenders will account to Pledgor for any surplus
and Borrowers shall remain liable to Lenders for any deficiency.

     Application of proceeds as between particular debts, obligations, or
liabilities of Borrowers, shall be in the absolute and sole discretion of the
Lenders. The Lenders shall have the right in their sole discretion to determine
which rights, security liens, security interests, or remedies, they shall at any
time pursue, relinquish, subordinate, modify, or take any action with respect
thereto, without in any way modifying or affecting any other security for the
Indebtedness or any of the Lenders' rights hereunder.

     8.   Pledgor agrees that Lenders' security interest in the Collateral and
in any and all other property belonging to Pledgor, pledged or hypothecated, to
secure indebtedness shall be as valid as if Pledgor had duly assigned, released,
transferred and delivered said property to the Borrowers and the Borrowers, with
full ownership thereof, had pledged said property to secure all such
Indebtedness upon the terms herein stated.

     9.   Any transferee of, or endorser, guarantor, or surety paying the
indebtedness secured hereby may take over all or any part of the Collateral
subject hereto, and shall succeed to all rights of the Lenders in respect
thereto and the Lenders shall be under no further responsibility therefore.

                                       5
<PAGE>   40

     10.  The Pledgor authorizes Lenders, without notice or demand and without
affecting any liability on the Indebtedness to:

          (a) renew, extend, accelerate, or change the time for repayment or
other terms of the Indebtedness secured hereby, including increasing or
decreasing the rate of interest;

          (b) take and hold security other than the Collateral herein described,
for the payment of the Indebtedness and to exchange, substitute, transfer,
enforce, waive and release such security; and

          (c) release or substitute any Borrower, endorser, guarantor, or other
Pledgor of the Indebtedness.

     11.  The Pledgor waives presentment, demand for performance, notice of
non-performance, protest, notice of protest, or notice of dishonor in connection
with an obligation or evidence of indebtedness held by Lenders as Collateral, or
in connection with any obligation of or evidence of indebtedness which
represents the Indebtedness secured thereby. The Lenders shall not be required
to examine into the validity of or to exchange or to collect on any Collateral
subject to this Agreement or to take any action necessary to hold any
corporation, issuer, or other parties liable on the Collateral; and diligence in
looking after, preserving, or acting with respect to the Collateral or
collecting the same is hereby waived by the parties hereto.

     12.  No delay on the part of the Lenders in the exercise of any right or
remedy shall operate as a waiver thereof, and no single or partial exercise by
the Lenders of any right or remedy shall preclude other or further exercise
thereof or the exercise of any other right or remedy. All of the Lenders' rights
and remedies whether evidenced hereby or by any other writing, shall be
cumulative and may be exercised from time to time singularly or concurrently.

     13.  This is a continuing Agreement and the rights, powers and remedies
apply to all past, present and future Indebtedness of the Borrowers to the
Lenders including that arising under successive transactions which continue the
Indebtedness, increase or decrease it, or create new Indebtedness. No notice of
creation or existence of any Indebtedness or of any renewal, extension, or
modification thereof, need be given to Pledgor. This agreement and related
financing statements shall be terminated upon payment in full of the
Indebtedness and all other sums and expenses required to be paid thereby,
provided however that for purposes of the foregoing, no Indebtedness shall be
deemed to exist under the terms of the Warrants prior to such time as Borrower
has been notified of the exercise of Lenders' rights under subsection (K) of the
Warrants. If this Agreement and the related financing statements shall have been
terminated

                                       6
<PAGE>   41

prior to the date on which Borrower is notified of the exercise of Lenders'
rights under subsection (K) of the Warrants, the effectiveness of this Agreement
shall automatically continue or be reinstated with respect to all amounts
payable in accordance with the terms of the Warrants upon notice to Borrower of
the exercise of Lenders' rights under subsection (K) of the Warrants. The breach
of the terms of any Note, Warrant, Security Agreement, Pledge or Business Loan
Agreement of whatsoever nature between Borrowers and Lenders, which is not cured
within any applicable grace period, shall constitute a default and breach of
all such agreements including this agreement.

     14.  Lenders may deliver the Collateral or any part of it to the Pledgor
and the receipt by the Pledgor discharges the Lenders from any liability or
responsibility for said Collateral.

     15.  This Agreement shall be governed and interpreted according to the laws
of the State of Michigan without regard to its conflict of law principles.
Parties agree that all actions and proceedings arising in connection with this
Agreement shall be litigated in the State Courts or the Federal District Courts
in the State of Michigan. The parties hereby waive any right that they may have
to change the venue of any action against it by any other party in accordance
with this paragraph. The parties hereby consent and submit to the jurisdiction
and venue of the State Courts and Federal District Courts of the State of
Michigan. This Agreement shall inure to the benefit of and be binding upon the
Lenders, their successors and assigns, including the assignees of any
Indebtedness secured by this Agreement, and the Pledgor and its legal
representatives, successors and assigns. In the event any provision of this
Agreement shall be invalid or unenforceable, in full or in part, neither the
validity nor the enforceability of the remainder of this Agreement shall be
affected in any way.

     16.  Nothing herein contained shall be construed to bind Lenders to perform
any of the Pledgor's obligations under any of the Collateral as a shareholder.

     17  This Assignment and Pledge Agreement has been negotiated between the
parties and shall be deemed to have been mutually drafted by them.

     In Witness Whereof, the parties hereto have executed this Agreement this
28th day of October, 1999.

LENDERS:                                             BORROWERS:

WHITE PINES LIMITED PARTNERSHIP I                    GENOMIC SOLUTIONS, INC.
By: White Pines G.P., L.L.C.,
     its general partner

By:                                                  By:
   ---------------------------------                    ------------------------
    Frederick L. Yocum, Chairman                        Jeffrey S. Williams
                                                            President

                                       7
<PAGE>   42
PACIFIC CAPITAL, L.P.
By: WP PACIFIC G.P., L.L.C.                            GENOMIC SOLUTIONS, LTD.
    a general partner

By:                                                  By:
   ---------------------------------------              ------------------------
   Frederick L. Yocum, Chairman

IAN R. N. BUND                                       GENOMIC SOLUTIONS, K.K.
YOCUM CONSULTING ASSOCIATES, INC.
VOLUNTEER HEALTHCARE ASSOCIATES, L.L.C
RONALD G. KALISH LIVING TRUST U/A/D                  By:
     SEPTEMBER 9, 1997                                  ------------------------
McDONALD INVESTMENTS INC. CUSTODIAN
     FBO DANIEL J. BOYLE IRA ROLLOVER
     ACCOUNT #85314893
KANTNER AND ASSOCIATES PROFIT SHARING
     PLAN U/A/D JANUARY 1, 1991
MICHAEL G. WILLIAMS
By:       White Pines Management, L.L.C.,
          a Michigan limited liability
          company, attorney-in-fact

By:
   ---------------------------------------
   Frederick L. Yocum, Chairman

CHASE VENTURE CAPITAL ASSOCIATES, L.P.

By:
   ---------------------------------------

AMERICAN HEALTHCARE FUND II

By:
  ----------------------------------------

------------------------------------------
J. MATTHEW MACKOWSKI

------------------------------------------
ROBERT G. SHEPLER

------------------------------------------
JOHN J. MACKOWSKI

GROVE INVESTMENT PARTNERS

By:
   ---------------------------------------

------------------------------------------
LAWRENCE J. KENT

                                       8
<PAGE>   43

------------------------------------------
JEFFREY S. WILLIAMS

------------------------------------------
KEVIN A. AUTON

------------------------------------------
ANDREW A. JAKIMCIUS

------------------------------------------
MICHAEL P. KUREK

------------------------------------------
STEVEN J. RICHVALSKY

                                       9
<PAGE>   44
                             SECRETARY'S CERTIFICATE
                              GENOMIC SOLUTIONS INC.

     The undersigned Secretary of Genomic Solutions Inc., a Delaware corporation
(the "Corporation"), hereby certifies as follows:

     1.   The following persons are the duly elected and acting officers of the
          Corporation, holding the office(s) set forth opposite his name below:

<TABLE>
<CAPTION>
          Name                                   Office
<S>                                              <C>
          Jeffrey S. Williams                    President, Chief Executive Officer
          Steven J. Richvalsky                   Executive Vice President, Treasurer,
                                                 Secretary and Chief Financial Officer
          Andrew A. Jakimcius                    Executive Vice President of Operations
          Michael P. Kurek                       Executive Vice President, Marketing and Sales
          William M. Skea                        Vice President
          Frank C. Becker                        Vice President
          Gregory H. Kinch                       Vice President
          Mary F. Lopez                          Vice President
          Mary Stanaway                          Vice President
</TABLE>

     2.   The following persons are the duly elected and acting directors of the
          Corporation:

<TABLE>
<S>                                     <C>                            <C>
          Jeffrey S. Williams           Robert G. Shepler              P. Nicholas "Nick" King
          Dan Mitchell                  Damion E. Wicker               J. Matthew Mackowski
</TABLE>

     3.   Attached hereto as Exhibit A is a true and complete copy of the
          Amended and Restated Certificate of Incorporation of the Corporation,
          as amended, as certified by the Delaware Secretary of State as of
          October 15, 1999. No action has been taken to amend the Certificate of
          Incorporation since that date.

     4.   Attached hereto as Exhibit B is a true and complete copy of the
          Certificate of Good Standing of the Corporation, as certified by the
          Delaware Secretary of State on October 15, 1999.

     5.   Attached hereto as Exhibit C is a true and complete copy of the
          Certificate of Good Standing of the Corporation, as certified by the
          Michigan Secretary of State on October 28, 1999.

     6.   Attached hereto as Exhibit D is a true and complete copy of the Bylaws
          of the Corporation, in effect on the date hereof.

     7.   Attached hereto as Exhibit E is a true and complete copy of the
          Consent Resolution that was duly adopted by the Board of Directors of
          the Corporation as of October 11, 1999, which has not been altered,
          amended or repealed and is in full force and effect as of the date
          hereof.

     IN WITNESS WHEREOF, the undersigned has executed this Certificate this 28th
day of October, 1999.

                                     /s/ Steven J. Richvalsky
                                     -----------------------------------
                                     Steven J. Richvalsky, Secretary and Chief
                                     Financial Officer

Attested By:
/s/ Jeffrey S. Williams
-----------------------------------
Jeffrey S. Williams, President, and
Chief Executive Officer
<PAGE>   45

                                   EXHIBIT A

<PAGE>   46
                                                                          PAGE 1

                                State of Delaware

                        Office of the Secretary of State

                          -----------------------------

       I, EDWARD J. FREEL, SECRETARY OF STATE OF THE STATE OF DELAWARE, DO
HEREBY CERTIFY THE ATTACHED ARE TRUE AND CORRECT COPIES OF ALL DOCUMENTS ON
FILE OF "GENOMIC SOLUTIONS INC." AS RECEIVED AND FILED IN THIS OFFICE.

       THE FOLLOWING DOCUMENTS HAVE BEEN CERTIFIED:

       CERTIFICATE OF INCORPORATION, FILED THE FIFTH DAY OF
DECEMBER, A.D. 1997, AT 9 O'CLOCK A.M.

       RESTATED CERTIFICATE, FILED THE TWENTY-FOURTH DAY OF
DECEMBER, A.D. 1997, AT 4:29 O'CLOCK P.M.

       CERTIFICATE OF AGREEMENT OF MERGER, FILED THE TWENTY-FOURTH DAY OF
DECEMBER, A.D. 1997, AT 4:30 O'CLOCK P.M.

       CERTIFICATE OF DESIGNATION, FILED THE THIRTEENTH DAY OF
MAY, A.D. 1998, AT 4 O'CLOCK P.M.

       CERTIFICATE OF AMENDMENT, FILED TEE TWENTY-SECOND DAY OF
MAY, A.D. 1998, AT 9:18 O'CLOCK A.M.

       CERTIFICATE OF DESIGNATION, FILED THE TWENTY-SECOND DAY OF
MAY, A.D. 1998, AT 9:19 O'CLOCK A.M.

                                     /s/ Edward J. Freel
[SECRETARY'S OFFICE SEAL]            -------------------------------------------
                                     Edward J. Freel, Secretary of State

2817427 8100H                        AUTHENTICATION: 0026617

                                     DATE:
<PAGE>   47

                                   EXHIBIT B

<PAGE>   48
                                                                          PAGE 1
                                State of Delaware

                        Office of the Secretary of State

                          ---------------------------

     I, EDWARD J. FREEL, SECRETARY OF STATE OF THE STATE OF DELAWARE, DO HEREBY
CERTIFY "GENOMIC SOLUTIONS INC." IS DULY INCORPORATED UNDER THE LAWS OF THE
STATE OF DELAWARE AND IS IN GOOD STANDING AND HAS A LEGAL CORPORATE EXISTENCE
SO FAR AS THE RECORDS OF THIS OFFICE SHOW, AS OF THE FIFTEENTH DAY OF OCTOBER,
A.D. 1999.

     AND I DO HEREBY FURTHER CERTIFY THAT THE ANNUAL REPORTS HAVE BEEN FILED TO
DATE.

     AND I DO HEREBY FURTHER CERTIFY THAT THE FRANCHISE TAXES HAVE BEEN PAID TO
DATE.

                                     /s/ Edward J. Freel
[SECRETARY'S OFFICE SEAL]            -------------------------------------------
                                     Edward J. Freel, Secretary of State

2817427              8300            AUTHENTICATION: 0027211

991436097                            DATE: 10-15-99
<PAGE>   49
                                   EXHIBIT C
<PAGE>   50
                            UNITED STATES OF AMERICA

                            [STATE OF MICHIGAN SEAL]

               MICHIGAN DEPARTMENT OF CONSUMER INDUSTRY SERVICES

                               LANSING, MICHIGAN

This is to Certify That

                             GENOMIC SOLUTIONS INC.

a DELAWARE profit corporation, was validly authorized on December 12, 1997, to
transact business or conduct affairs in Michigan, and that said corporation
holds a valid certificate of authority to transact business or conduct affairs
in this State.

This certificate is issued to attest to the fact that the corporation is in good
standing in this office as of this date and is duly authorized to transact
business or conduct affairs in Michigan and for no other purpose. It is in the
usual form, made by me as the proper officer, and is entitled to have full faith
and credit given it in every court and office within the United States.

[STATE OF MICHIGAN SEAL]                In testimony whereof, I have hereunto
Sent by Facsimile Transmission          set my hand and affixed the Seal of the
                                        Department, in the City of Lansing, this
                                        28th day of October, 1999.

                                        /S/ Julie Croll, Director

174 0457943                 Corporation, Securities and Land Development Bureau
<PAGE>   51

                                   EXHIBIT D

<PAGE>   52

                                     BYLAWS
                                       OF
                             GENOMIC SOLUTIONS INC.

                            (a Delaware corporation)

                              Filed as Exhibit 3.3

<PAGE>   53

                                   EXHIBIT E

<PAGE>   54

                CONSENT RESOLUTION OF THE BOARD OF DIRECTORS OF
                             GENOMIC SOLUTIONS INC.

     WHEREAS, the General Corporation Law of the State of Delaware provides that
if all of the directors of a corporation shall consent in writing to any action
to be taken by that corporation, such action shall be as valid a corporate
action as though it had been authorized at a meeting of the directors; and

     WHEREAS, the undersigned, all of the directors of Genomic Solutions Inc., a
Delaware corporation (the "Corporation"), desire that the actions expressed
in the resolutions set forth below be taken.

     NOW, THEREFORE, the undersigned declare that the actions expressed in the
following resolutions are hereby taken by the Corporation's Board of Directors
(the "Board") as of October 11, 1999.

     AUTHORIZATION OF SUBDEBT FINANCING

     WHEREAS, the Board has determined that it would be in the best interests of
     the Corporation to offer and sell approximately $3,500,000 face amount of
     subordinated debentures with 5 year maturity (the "Debt") together with up
     to 1,400,000 warrants to purchase the Corporation's common stock (the
     "Warrants") to certain existing shareholders of the Corporation and
     potential new investors should certain existing shareholders not fully
     exercise their pro-rata rights, all collectively referred to as the Lenders
     (the "Lenders"), and

     WHEREAS, the Board has been provided with the principal economic terms
     of the Debt and the Warrants (collectively, the "Sub. Debt Financing"); and

     WHEREAS, as part of the consideration under the Sub. Debt Financing the
     Corporation will issue the Lenders warrants exercisable up to 1,400,000
     shares of the Corporation's common stock (the "Warrant"); and

     WHEREAS, up to 250,000 additional shares of common stock of the Corporation
     may, upon the election by the Lenders, be issued in respect to interest
     payments on the Debt;

<PAGE>   55

     WHEREAS, the Board has determined that it would be in the best interests
     of the Corporation and its shareholders for the Corporation to authorize
     and conduct the Sub. Debt Financing.

     RESOLVED, that the Corporation is authorized, empowered and directed to
     conduct the Sub. Debt Financing; and

     RESOLVED, FURTHER, that the Board approves the terms of the Warrant and
     hereby reserves 1,400,000 shares of authorized but unissued common stock
     for issuance according to the terms of the Warrant and hereby reserves
     250,000 shares of authorized but unissued common stock for issuance in
     respect of interest in accordance with the terms of the Debt.

     RESOLVED, FURTHER, that upon issuance against payment received in
     accordance with the terms of the Warrants or the Debt such shares of common
     stock will be validly issued, fully paid and non-assessable.

     RESOLVED, FURTHER, that the Corporation is authorized, empowered and
     directed to enter into, and to consummate the transactions contemplated in
     the Sub. Debt Financing and any and all other agreements, instruments and
     documents which relate to or are contemplated in the Sub. Debt Financing
     (the "Attendant Documents"), all as finally completed in accordance with
     these resolutions; and

     RESOLVED, FURTHER, that the officers of the Corporation (the "Officers"),
     or any of them acting alone, are authorized, empowered and directed, for
     and on behalf of the Corporation, to negotiate, prepare, finalize, modify,
     the Sub Debt Financing and Attendant Documents on such terms and conditions
     as are not materially inconsistent with the economic terms and conditions
     set forth in the terms presented to the Board, and the Officers, or any of
     them acting alone, are further authorized, empowered and directed, for and
     on behalf of the Corporation, to execute, deliver, amend and, if necessary,
     file and record with the appropriate authorities any and all documents,
     instruments and papers related to the Sub. Debt Financing and Attendant
     Documents, all as finally completed in accordance with these resolutions.

<PAGE>   56
     COUNTERPARTS; COPIES

     RESOLVED, that this Written Consent Resolution may be executed in any
     number of counterparts, each of which shall be deemed to be an original and
     all of which together shall constitute one instrument.

     RESOLVED, FURTHER, that copies (facsimile, photostatic or otherwise) of
     signatures to this Written Consent Resolution shall be deemed to be
     originals, and may be relied on to the same extent as the originals.

             [The remainder of this page intentionally left blank.]
<PAGE>   57
IN WITNESS WHEREOF, the undersigned have executed this Consent Resolution of the
Board of Directors of Genomic Solutions Inc. as of October    1999.
                                                           --

                                    /s/ Jeffrey S. Williams
                                    --------------------------------------------
                                    Jeffrey S. Williams

                                    /s/ Robert G. Shepler
                                    --------------------------------------------
                                    Robert G. Shepler

                                    /s/ J. Matthew Mackowski
                                    --------------------------------------------
                                    J. Matthew Mackowski

                                    /s/ Dan Mitchell
                                    --------------------------------------------
                                    Dan Mitchell

                                    /s/ Damion E. Wicker
                                    --------------------------------------------
                                    Damion E. Wicker

                                    /s/ Nick King
                                    --------------------------------------------
                                    Nick King<PAGE>   1
                                                                Attachments to
                                                                EXHIBIT 10.14(a)

                                 March 24, 2000

Genomic Solutions, Inc.
4355 Varsity Drive, Suite E
Ann Arbor, MI  48108
                                        AMENDMENT NO. 3 TO LETTER LOAN AGREEMENT
Gentlemen:

         This letter (this "Amendment"), amends the Letter Loan Agreement dated
August 10, 1998 (as amended by the Amendment No. 1 to Letter Loan Agreement
dated April 29, 1999 and Amendment No. 2 to Letter Loan Agreement dated February
29, 2000 but effective as of September 30, 1999, the "Agreement") by and between
Comerica Bank, a Michigan banking corporation ("Bank"), and Genomic Solutions,
Inc., a Delaware corporation ("Company"). Terms used and not otherwise defined
in this Amendment have the meanings ascribed to them in the Agreement.

         In consideration of the mutual promises made in this Amendment, and
other valuable consideration, the receipt and sufficiency of which is
acknowledged, Bank and Company agree as follows:

1.       The first unnumbered paragraph on page one of the Agreement is amended
by replacing the term "Two Million Dollars ($2,000,000)" with the term "Twenty
Two Million Dollars ($22,000,000)."

2  .     Section 1 of the Agreement is amended to insert the following
definitions in appropriate alphabetical order:

         "Cash" shall mean money, currency or a credit balance in a general
         deposit account with a financial institution.

         "Cash Equivalents" shall mean (i) unencumbered securities issued or
         directly and fully guaranteed or insured by the United States of
         America or any agency or instrumentality thereof (provided that the
         full faith and credit of the United States of America is pledged in
         support thereof) having maturities of not more than three years from
         the date of acquisition, (ii) unencumbered marketable direct
         obligations issued by any State of the United States of America or any
         local government or other political subdivision thereof rated (at the
         time of acquisition of such security) at least AA by Standard & Poor's
         Corporation ("S&P") or the equivalent thereof by Moody's Investors
         Service, Inc. ("Moody's") having maturities of not more than one year
         from the date of acquisition, (iii) unencumbered U.S. Dollar

<PAGE>   2

Genomic Solutions, Inc.
March 24, 2000
Page 2

         denominated time deposits, certificates of deposit and bankers'
         acceptances of (x) Bank, (y) any domestic commercial bank of recognized
         standing having capital and surplus in excess of $500,000,000 or (z)
         any bank whose short-term commercial paper rating (at the time of
         acquisition of such security) by S&P is at least A-l or the equivalent
         thereof or by Moody's is at least P-1 or the equivalent thereof (any
         such bank, an "Approved Bank"), in each case with maturities of not
         more than six months from the date of acquisition, (iv) unencumbered
         commercial paper and variable or fixed rate notes issued by Bank or by
         the parent company of Bank and commercial paper and variable rate notes
         issued by, or guaranteed by, any industrial or financial company with a
         short-term commercial paper rating (at the time of acquisition of such
         security) of at least A-1 or the equivalent thereof by S&P or at least
         P-1 or the equivalent thereof by Moody's, or guaranteed by any
         industrial company with a long-term unsecured debt rating (at the time
         of acquisition of such security) of at least AA or the equivalent
         thereof by S&P or the equivalent thereof by Moody's and in each case
         maturing within one year after the date of acquisition and (v)
         unencumbered repurchase agreements with Bank maturing within one year
         from the date of acquisition that are fully collateralized by
         investment instruments that would otherwise be Cash Equivalents.

         "Liquid Assets" shall mean Cash, and Cash Equivalents.

         "unencumbered" shall mean with respect to any asset, that such asset is
         not subject to any voluntary or involuntarily lien, security interest,
         mortgage, pledge or other encumbrance, including without limitation any
         lien or security interest in favor of the Bank.

3.       Section 2 of the Agreement is amended by replacing the term "Two
         Million Dollars ($2,000,000)" with the term "Twenty Two Million Dollars
         ($22,000,000)."

4.       The following Section 2 A is inserted immediately after Section 2:

         2A Standby letters of credit ("Letters of Credit") may be issued by
         Bank on behalf of Company from time to time under the Line of Credit.
         The undrawn amount of the Letters of Credit shall not exceed Two
         Million Dollars ($2,000,000) at any time. Letters of Credit shall be on
         terms and conditions (including fees) and issued subject to
         documentation acceptable to Bank. Each Letter of Credit shall expire on
         the earlier to occur of 360 days from its date of issuance and the
         Maturity Date as set forth in the Note.

5.       Section 3 is amended to add the following Section (g):

<PAGE>   3
Genomic Solutions, Inc.
March 24,  2000
Page 3

         (g) Proceeds of loans under the Line of Credit and Letters of Credit
         shall be used for general, corporate purposes, including working
         capital.

6.       Section 4(m) is amended to replace the term "April 1998 Subordinated
         Debt" with the term "April 1999 Subordinated Debt."

7.       Section 4 of the Agreement is amended to add the following subsections
         (n) and (o):

         (n) Maintain at all times after Company's initial public offering
         (including without limitation after payment of the debt now owing under
         the April 1999 and October, 1999 Subordinated Debt financing)
         unencumbered Liquid Assets of at least $10,000,000.

         (o) Maintain at all times cash collateral acceptable to and under the
         control of the Bank in which Bank shall have a first priority,
         perfected security interest in an amount not less than $20,000,000. If
         and when the Line of Credit is permanently and irrevocably reduced, the
         amount of cash collateral required shall be reduced by the amount by
         which the Line of Credit is reduced.

8.       Section 5(c)(viiI) is amended to read in its entirety:

         (viii) liens or encumbrances on assets of Company and its subsidiaries
         in connection with the April, 1999 Subordinated Debt financing and the
         October, 1999 Subordinated Debt financing.

9.       The form of promissory note annexed to this Amendment as Exhibit A is
         substituted for the form of promissory note annexed to the Agreement as
         Exhibit A.

<PAGE>   4

Genomic Solutions, Inc.
March 24, 2000
Page 4

10. In consideration for the Bank's entering into this Amendment, within 31 days
of the date of this Amendment, the Company shall pay the Bank a non-refundable
closing fee of $37,500. In addition, Company shall reimburse Bank for all of
Bank's out-of-pocket expenses and reasonable attorney fees incurred in
connection with the closing of the transactions contemplated by this Amendment.

11. The Company hereby reaffirms the representations and warranties set forth in
Section 3 of the Agreement and acknowledges and confirms that those
representations and warranties are continuing representations and warranties
during the life of the Agreement.

12. The effectiveness of this Amendment is conditioned on the Bank's receipt of
the following:

          a.   A fully executed promissory note in the form annexed hereto as
               Exhibit A.

          b.   The documents required by the attached Closing Agenda, fully
               executed by the parties thereto the Banks satisfaction.

13. Except as amended by this Amendment, the terms of the Agreement and the
other Loan Documents shall remain in full force and effect.

14. If the foregoing is acceptable to Company, please indicate such with the
authorized signature of Company as provided below.

                                  Very truly yours,

                                  COMERICA BANK

                                  By: Ronald M. Ruks
                                      ------------------------------------------

                                  Its: Assistant Vice President
                                      ------------------------------------------

ACCEPTED AND AGREED:

GENOMIC SOLUTIONS, INC.

<PAGE>   5

Genomic Solutions, Inc.
March 24, 2000
Page 5

By:      Jeffrey S. Williams
         -----------------------
Its:     President and CEO
         -----------------------
Dated:
         -----------------------

Each of the undersigned Guarantors acknowledges the Company's execution of the
foregoing Amendment and consents to the terms of the Amendment. Each Guarantor
ratifies and confirms its Guaranty of the obligations of the Company to the Bank
and acknowledges that such Guaranty remains in fully force and effect in
accordance with its terms.

GENOMIC SOLUTIONS, K.K.

By:      Jeffrey S. Williams
         ---------------------------
Its:     Chairman
         ---------------------------
Dated:
         ---------------------------

GENOMIC SOLUTIONS, LTD.

By:      Jeffrey S. Williams
         ---------------------------
Its:     Chairman
         ---------------------------
Dated:
         ---------------------------

<PAGE>   6

                    AMENDMENT NO.1 TO SUBORDINATION AGREEMENT

         This Amendment No. 1 to Subordination Agreement (this "Amendment") is
made as of March 24, 2000 by and among the Genomic Solutions, Inc., Genomic
Solutions, Ltd. and Genomic Solutions K.K., (each, a "Borrower") and, together,
(the "Borrowers"), the parties listed on the signature pages hereto as Creditors
(each "Creditor") and collectively ("Creditors") and Comerica Bank ("Bank").

                                    RECITALS

A.   The parties have entered into the Subordination Agreement dated as of April
     23, 1999 (the "Subordination Agreement").

B.   The parties wish to amend the Subordination Agreement as provided herein.

     THEREFORE, in consideration of the recitals, and other valuable
consideration, the receipt and sufficiency of which is acknowledge, Bank,
Borrowers and Creditors agree as follows:

1.   The proviso following the phrase (the "Senior Indebtedness") in the tenth
     line of Section 1 of the Subordination Agreement is amended to read:

     provided, however, that Senior Indebtedness does not include aggregate
principal amounts at any one time outstanding in excess of the sum of (a) an
amount equal to $3,000,000 during the calendar year 1999, $6,000,000 during the
calendar year 2000, $7,000,000 during the calendar year 2001 and $8,000,000
during the calendar year 2002 and thereafter, plus (b) the aggregate principal
amount of all indebtedness owing from time to time from the Borrower to the Bank
secured by cash and/or cash equivalents to the extent such indebtedness is paid
or satisfied by such cash and/or cash equivalents.

1.   Section 20 of the Subordination Agreement is amended to add the
following additional subsection 20G.

     G. Notwithstanding anything to the contrary in this Agreement, if the
Borrower closes an initial public offering on or before June 1, 2001 pursuant to
the Registration Statement filed with the Securities and Exchange Commission and
proceeds of that initial public offering exceed $50,000,000 (an "IPO"), then
Creditors may ask for, demand, sue for, take or receive from Borrowers the full
outstanding principal balance of the Notes notwithstanding whether a Standstill
Notice has been given to Creditors.

2.   After an IPO, evidence of the Subordinated Indebtedness shall no longer be
required to contain the restrictive legend set forth in the second sentence of
Section 6 of the Subordination Agreement.

<PAGE>   7

3.    Except as amended by this Amendment, the terms of Subordination Agreement
shall remain in full force and effect.

      Executed as of the date first written above.

                    [Signatures begin on the following page]

<PAGE>   8
   WHITE PINES LIMITED PARTNERSHIP I
   By: White Pines G.P., L.L.C. its general
       partner

   By: /s/ Frederick L. Yocum
       -----------------------------
       Frederick L. Yocum, Chairman

   PACIFIC CAPITAL, L.P.
   By:  WP Pacific G.P., L.L.C., a general
        partner

   By: /s/ Frederick L. Yocum
       -----------------------------
       Frederick L. Yocum, Chairman
IAN R. N. BUND SMITH BARNEY
   PROTOTYPE PS PLAN ACCOUNT
   #206-08291-12445
YOCUM CONSULTING ASSOCIATES, INC.
VOLUNTEER HEALTHCARE ASSOCIATES, L.L.C
MCDONALD INVESTMENTS INC. CUSTODIAN
   FBC S. STERLING MCMILLAN III IRA
   ROLLOVER ACCOUNT #85362191
RONALD G. KALISH LIVING TRUST U/A/D
   SEPTEMBER 9, 1997
LOIS F. MARLER
MCDONALD INVESTMENTS INC. CUSTODIAN
   FBO DANIEL J. BOYLE IRA
   ROLLOVER ACCOUNT #85314893
NATIONAL CITY BANK OF MI/IL CUSTODIAN
   FBO HERBERT S. AMSTER IRA
   ROLLOVER ACCOUNT DATED JUNE 12, 1991
   #MI-1491-00-4
KANTNER AND ASSOCIATES PROFIT SHARING
   PLAN U/A/D JANUARY 1, 1991
MICHAEL G. WILLIAMS
By:  White Pines Management, L.L.C.,
     a Michigan limited liability
     company, attorney-in-fact

By: /s/ Frederick L. Yocum
------------------------------
 Frederick L. Yocum, Chairman

<PAGE>   9

COMERICA BANK                                        BANK'S ADDRESS:

By:  Ronald M. Ruks                                  500 Woodward Avenue
    -------------------------------                  Detroit, MI 48226
Its:  Assistant Vice President
    -------------------------------

                            BORROWER'S ACKNOWLEDGMENT

The undersigned ("Borrowers") accept notice of the subordination created by this
Agreement and agree that they will take no action inconsistent with this
Agreement. Borrowers agree that the Bank may, at its option, without notice and
without limiting Bank's other rights, upon any breach by Creditors holding at
least 10% of the aggregate outstanding principal amount of the Subordinated
Indebtedness ("Material Creditors") of, or purported termination by Material
Creditors of, this Agreement, declare all Senior Indebtedness to be immediately
due and payable and/or terminate any commitments of Bank to Borrowers.

GENOMIC SOLUTIONS, INC.                     BORROWERS' ADDRESS

By:  Jeffrey S. Williams                    4355 Varsity Drive
    -------------------------------         Ann Arbor, MI 48108
Its: President & CEO
    -------------------------------

GENOMIC SOLUTIONS, LTD

By:  Jeffrey S. Williams
    -------------------------------
Its: Chairman
    -------------------------------
GENOMIC SOLUTIONS, K.K.

By:  Jeffrey S. Williams
    -------------------------------
Its: Director
    -------------------------------

<PAGE>   10
                      AMENDMENT NO. 1 TO SUBORDINATION AGREEMENT

     This Amendment No. 1 to Subordination Agreement (this "Amendment") is made
as of March 24, 2000 by and among the Genomic Solutions, Inc., Genomic
Solutions, Ltd. and Genomic Solutions K.K., (each, a "Borrower") and, together,
(the "Borrowers"), the parties listed on the signature pages hereto as Creditors
(each "Creditor") and collectively ("Creditors") and Comerica Bank ("Bank").

                                   RECITALS

A.  The parties have entered into the Subordination Agreement dated as of
    October 28, 1999 (the "Subordination Agreement").

B.  The parties wish to amend the Subordination Agreement as provided herein.

    THEREFORE, in consideration of the recitals, and other valuable
consideration, the receipt and sufficiency of which is acknowledge, Bank,
Borrowers and Creditors agree as follows:

1.  The proviso following the phrase (the "Senior Indebtedness") in the tenth
    line of Section 1 of the Subordination Agreement is amended to read:

    provided, however, that Senior Indebtedness does not include aggregate
principal amounts at any one time outstanding in excess of the sum of (a) an
amount equal to $3,000,000 during the calendar year 1999, $6,000,000 during the
calendar year 2000, $7,000,000 during the calendar year 2001 and $8,000,000
during the calendar year 2002 and thereafter, plus (b) the aggregate principal
amount of all indebtedness owing from time to time from the Borrower to the
Bank secured by cash and/or cash equivalents to the extent such indebtedness is
paid or satisfied by such cash and/or cash equivalents.

1.  Section 20 of the Subordination Agreement is amended to add the following
additional subsection 20G.

    G. Notwithstanding anything to the contrary in this Agreement, if the
Borrower closes an initial public offering on or before June 1, 2001 pursuant
to the Registration Statement filed with the Securities and Exchange Commission
and proceeds of that initial public offering exceed $50,000,000 (an "IPO"),
then Creditors may ask for, demand, sue for, take or receive from Borrowers the
full outstanding principal balance of the Notes notwithstanding whether a
Standstill Notice has been given to Creditors.

2.  After an IPO, evidence of the Subordinated Indebtedness shall no longer be
required to contain the restrictive legend set forth in the second sentence of
Section 6 of the Subordination Agreement.

<PAGE>   11

3.  Except as amended by this Amendment, the terms of Subordination Agreement
shall remain in full force and effect.

    Executed as of the date first written above.

                      [Signatures begin on the following page]
<PAGE>   12

     WHITE PINES LIMITED PARTNERSHIP I
     By:  White Pines G.P., L.L.C. its general
          partner

     By:  /s/ Frederick L. Yocum
          ------------------------------------
          Frederick L. Yocum, Chairman

     PACIFIC CAPITAL, L.P.
     By:  WP Pacific G.P., L.L.C., a general
          partner

     By:  /s/ Frederick L. Yocum
          ------------------------------------
          Frederick L. Yocum, Chairman

IAN R. N. BUND
YOCUM CONSULTING ASSOCIATES, INC.
VOLUNTEER HEALTHCARE ASSOCIATES, L.L.C.
RONALD G. KALISH LIVING TRUST U/A/D
     SEPTEMBER 9, 1997
McDONALD INVESTMENTS INC. CUSTODIAN
     FBO DANIEL J. BOYLE IRA ROLLOVER
     ACCOUNT #85314893
KANTNER AND ASSOCIATES PROFIT SHARING
     PLAN U/A/D JANUARY 1, 1991
MICHAEL G. WILLIAMS
By:  White Pines Management, L.L.C.,
     a Michigan limited liability
     company, attorney-in-fact

By:  /s/ Frederick L. Yocum
     -----------------------------------------
     Frederick L. Yocum, Chairman
<PAGE>   13

COMERICA BANK                            BANK'S ADDRESS:

By: Ronald M. Ruks                       500 Woodward Avenue
   --------------------------            Detroit, MI 48226
Its: Assistant Vice President
    -------------------------

                             BORROWER'S ACKNOWLEDGMENT

The undersigned ("Borrowers") accept notice of the subordination created by
this Agreement and agree that they will take no action inconsistent with this
Agreement.  Borrowers agree that the Bank may, at its option, without notice
and without limiting Bank's other rights, upon any breach by Creditors holding
at least 10% of the aggregate outstanding principal amount of the Subordinated
Indebtedness ("Material Creditors") of, or purported termination by Material
Creditors of, this Agreement, declare all Senior Indebtedness to be immediately
due and payable and/or terminate any commitments of Bank to Borrower:

GENOMIC SOLUTIONS, INC.                      BORROWERS' ADDRESS

By: Jeffrey S. Williams                      4355 Varsity Drive
   -------------------------------           Ann Arbor, MI 48108
Its: President and CEO
    ------------------------------

GENOMIC SOLUTIONS, LTD.

By: Jeffrey S. Williams
   -------------------------------
Its: Chairman
    ------------------------------

GENOMIC SOLUTIONS, K.K.

By: Jeffrey S. Williams
   -------------------------------
Its: Director
    ------------------------------

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