Document:

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EXHIBIT 4.6

                                   Sabre, Inc.                 Fax: 817-967-4911
                           4255 Aman Carter Boulevard            www.sabre.com
                                    MD 4224
                              Fort Worth, TX 76155

August 10, 2001

800 Travel Systems, Inc.
4802 Gunn Hwy., Suite 140
Tampa, Florida 33624
Attention: Peter M. Sontag, Chairman & CEO

         Re:      Term Note Agreement (the "Term Note Agreement"), dated January
                  22, 2001, between 800 Travel Systems, Inc. (the "Company") and
                  Sabre Inc. ("Sabre")

Gentlemen:

         You have advised that as of the fiscal quarter ended June 30, 2001, the
Company was not in compliance with the financial covenants contained in
subparagraphs 2.(b)(ii) and (iii) to Schedule 7(i) to the Term Note Agreement,
and you have requested that Sabre waive the Company's noncompliance therewith
for the fiscal quarter ended June 30, 2001 and for the next fiscal quarter
ending September 30, 2001.

         Please be advised that upon consideration of your request, Sabre hereby
agrees to waive compliance by the Company with the financial covenants contained
in subparagraphs 2.(b) (ii) and (iii) to Schedule 7(i) to the Term Note
Agreement for the fiscal quarter ended June 30, 2001 and for the next fiscal
quarter ending September 30, 2001, upon the following terms and conditions:

         (a)      This waiver is limited to those items specifically set forth
                  above and the remaining terms of the Term Note Agreement,
                  including without limitation all security interests in the
                  Sabre Collateral (as defined in the Term Note Agreement),
                  remain in full force and effect;

         (b)      This waiver letter contains the entire understanding of the
                  parties with respect to the subject matter hereof, and no
                  other representations, promises, agreements or understandings
                  regarding the subject matter hereof shall be of any force or
                  effect unless in writing executed by Sabre; and

         (c)      This waiver letter shall not be construed so as to confer any
                  right or benefit upon any other person or entity other than
                  the Company.

SABRE INC.
By /s/ Eric Speck
   -------------------------------
   Eric Speck
   Group President, Travel Marketing and Distribution1
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                          LEASE SURRENDER AGREEMENT AND
                            SECOND AMENDMENT TO LEASE
                            -------------------------
     THIS  LEASE  SURRENDER  AGREEMENT  AND  SECOND  AMENDMENT  TO  LEASE  (the
"Agreement")  made  as  of  May  1,  2001, between BALLARDVALE INVESTORS LIMITED
PARTNERSHIP, a Pennsylvania limited partnership with an address at GSB Building,
Suite 401, One Belmont Avenue, Bala Cynwyd, PA 19004 (the "Landlord") and ASCENT
PEDIATRICS,  INC,  with  an  address  at  187  Ballardvale  Street,  Wilmington,
Massachusetts  01887  (the  "Tenant").
                                 R E C I T A L S
                                 ---------------
     WHEREAS, by Lease dated November 21, 1996 Landlord leased to Tenant certain
premises  containing 14,320 rentable square feet (the "Leased Premises") located
on  the  first  floor  of  the  building  located  at  187  Ballardvale  Street,
Wilmington,  Massachusetts  01887  (the  "Building");
WHEREAS,  said Lease was subsequently modified by First Amendment to Lease dated
September  18,  1997  (said  Lease  with  all  amendments,  the "Lease") whereby
Landlord  leased 4,542 rentable square feet to Tenant on the second floor of the
Building;
WHEREAS,  the  Tenant desires to surrender a portion of the Leased Premises (the
"Surrendered  Space")  as  shown  on Exhibit A-2 attached hereto and made a part
                                     -----------
hereof,  and  Landlord  is  willing  to accept such surrender upon the terms and
conditions  set  forth  in  this  Agreement;
                                   AGREEMENTS
                                   ----------
     NOW  THEREFORE,  in consideration of the mutual agreements herein contained
and  for  other  good  and  valuable consideration, the mutual receipt and legal
sufficiency  of which are hereby acknowledged, Landlord and the Tenant do hereby
agree  as  follows:
1.     DEFINED  TERMS.  All  capitalized  terms used in this Agreement which are
       --------------
not  defined  herein  shall  have  the  meanings  ascribed to them in the Lease.
2.     SURRENDER  DATE.  On  May  15,  2001 (the "Surrender Date"), Tenant shall
       ---------------
surrender possession of the Surrendered Space (being 100 rentable square feet in
area)  to Landlord vacant and broom clean (subject to completion of certain work
by  Landlord  described  in  Section  6  hereof)  and otherwise in the condition
required  by  the  terms  and  provisions  of the Lease.  On the Surrender Date,
Landlord  agrees  to  accept  the  surrender of the Surrendered Space subject to
Tenant's  compliance with all its obligations under this Agreement and under the
Lease.
3.     MUTUAL  RELEASE.  As  of the Surrender Date: (a) , Tenant hereby releases
       ---------------
Landlord  from  any  and all claims, obligations and liabilities of any kind and
nature  whatsoever  thereafter  arising  out  of  or  in  connection  with  the
Surrendered  Space and the Lease with respect to the Surrendered Space only; and
(b) Landlord hereby releases Tenant from and against all claims, obligations and
liabilities  thereafter  arising  out  of  or in connection with the Surrendered
Space  and  the  Lease  with  respect to the Surrendered Space only, except with
respect  to  those  obligations of Tenant expressly provided in the Lease and in
this  Agreement  to  survive the Surrender Date or the termination of the Lease.
4.     CONDITIONS  FOR  TERMINATION OF TENANT OBLIGATIONS.  Tenant's obligations
       --------------------------------------------------
and  liabilities under the Lease with respect to the Surrendered Space shall not
terminate  on  the  Surrender  Date,  nor  shall the releases in Section 3 above
become  effective, unless Tenant performs and observes all its obligations under
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the  Lease  relating or allocable to the Surrendered Space through and including
the  Surrender  Date,  including, but not limited to, payment of all Annual Base
Rent  and  Additional  Rent.
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5.     SURVIVAL  OF  TENANT  OBLIGATIONS.  Tenant's  liability  for  any and all
       ---------------------------------
amounts  due  under  the Lease allocable to the Surrendered Space which have not
been  determined  as of the Surrender Date shall survive the Surrender Date, and
shall  be  due  and  payable  when  determined  and  billed  by  Landlord.
6.     LANDLORD'S  WORK.  Landlord  agrees  that  in  connection  with  Tenant's
       ----------------
delivery  of  the  surrendered  Space,  Landlord,  at its expense, will (a) move
Tenant's furniture and other personal property from the Surrendered Space to the
Leased  Premises;  (b)  relocate  Tenant's keypad; and (c) install an entry door
(using  "building standard" materials) to the balance of the Leased Premises for
access  by  Tenant  to  its  Leased  Premises.
7.     REPRESENTATIONS  AND  WARRANTIES.  Tenant  represents,  warrants  and
       --------------------------------
covenants  to  Landlord  that:  (a)  the Surrendered Space is in good repair and
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condition  and  in  compliance  with  the terms and conditions of the Lease; (b)
Tenant has not done or suffered, and will not do or suffer, anything whereby the
Lease  or  the  Surrendered  Space  have  (or  will)  become  encumbered  by any
mechanics'  or materialmens' liens or in any other manner whatsoever; (c) Tenant
is  duly authorized to execute, deliver and perform this Agreement; and (d) this
Agreement  is  valid,  binding and enforceable against Tenant in accordance with
its  terms.
8.     CONTINUING  VALIDITY OF LEASE AND LEASE OBLIGATIONS.  Landlord and Tenant
       ---------------------------------------------------
acknowledge  that  the surrender under this Agreement of a portion of the Leased
Premises shall apply to the Surrendered Space only, and all the terms, covenants
and  conditions  of  the  Lease,  as  modified or amended by this Agreement, are
hereby ratified and confirmed, and shall continue to be and remain in full force
and  effect  as  to  that  remaining portion of the Leased Premises which is not
surrendered  hereunder.  Tenant  acknowledges  that the remaining portion of the
Leased  Premises  not  surrendered under this Agreement contains 18,762 rentable
square  feet  of  space  (14,220  rentable square feet on the first floor of the
Building  and  4,542  on  the  second  floor  of  the  Building).
9.     LEASE  AMENDMENTS.  If  Tenant  complies  with  all  of the terms of this
       -----------------
Agreement on or before the Surrender Date, then effective on the Surrender Date,
the Lease shall be amended as follows to reflect the decrease in the area of the
Leased  Premises:
(a)     Reduction of Premises Area.  Section I of the Lease is amended by adding
        --------------------------
     the  following  at  the  end  of  the  second  paragraph  thereof:
     "Effective  on  May  15,  2001  (the "Surrender Date"), the premises on the
first  floor of the Building shall be reduced by 100 rentable square feet, which
space  is  more  particularly  identified  on  Exhibit  A-2  attached hereto and
                                               ------------
incorporated  herein  by  reference  (hereinafter  the  "Surrendered  Space")."
(b)     Reduction of Tenant's Proportionate Share (Taxes).  Section XI(c) of the
        -------------------------------------------------
     Lease  is amended by adding the following after the first sentence thereof:
     "Effective  on the Surrender Date, "Tenant's Proportionate Share" for taxes
shall  be  eighteen  and  10/100  percent  (18.10%)."
(c)     Reduction of Tenant's Proportionate Share for Operating Cost Escalation.
        -----------------------------------------------------------------------
     Section  XI(i)  of  the  Lease is amended by adding the following after the
second  sentence  thereof:
     "Effective  on  the  Surrender  Date,  Tenant's  Proportionate  Share  for
Operating  Cost  Escalation  shall  be  eighteen  and  10/100 percent (18.10%)."
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(d)     Reduction of Fixed Rent Payments.  Section IV of the Lease is amended to
        --------------------------------
     add  the  following  to  the  first  paragraph:
     "Effective  on  the  Surrender  Date, the new rentable space of the demised
premises  on  the  first  floor of the Building shall be reduced by 100 rentable
square  feet  of  space for purposes of calculating the fixed rent payable under
this  Section  IV."
10.     COUNTERPARTS.  This  Agreement  may  be  executed  in  any  number  of
        ------------
counterparts,  each  of  which  shall  be  an  original,  but all of which shall
        -
constitute  one  instrument.  This  Agreement  represents  the  entire agreement
between  the  parties  concerning  the  subject matter hereof and supersedes all
prior  discussions,  negotiations  and  agreements  between  them  regarding the
subject  matter  of  this  Agreement.
11.     MISCELLANEOUS.  The provisions of this agreement shall bind and inure to
        -------------
the  benefit of the heirs representatives, successors and assigns of the parties
hereto  and  Tenant  hereby  warrants  to  Landlord  that  it has not heretofore
assigned, mortgaged or otherwise transferred, amended or encumbered, voluntarily
or  involuntarily,  the Lease or its interest therein.  This Agreement shall not
be  binding upon or enforceable against Landlord unless and until Landlord shall
have executed and unconditionally delivered to Tenant an executed counterpart of
this  Agreement.  This  Agreement  shall be governed and construed in accordance
with  the  laws  of  the  Commonwealth  of  Massachusetts.
IN  WITNESS  WHEREOF,  Landlord  and  Tenant  have  caused  this Agreement to be
executed  on  the  date  first  above  written.
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<CAPTION>

<S>                                    <C>
WITNESSED BY:                          LANDLORD:

_________________________________      BALLARDVALE INVESTORS LIMITED PARTNERSHIP

                                       By:  Bergen of Ballardvale, Inc.,
_________________________________           General Partner

                                       By:__________________________________
                                       Name:
                                       Title:

__________________________________     TENANT:
                                       ASCENT PEDIATRICS, INC.

                                       By:__________________________________
                                       Name:
__________________________________     Title:
</TABLE>

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