Document:

Exhibit 10.10.4

 

FOURTH AMENDMENT TO EXCLUSIVE PATENT
LICENSE AGREEMENT

 

This Fourth Amendment
(this “Fourth Amendment”), effective as of January 2, 2018, amends the Exclusive Patent License Agreement, effective
March 14, 2006, as amended by the First Amendment to Exclusive Patent License Agreement, effective as of February 25, 2011, the
Second Amendment to Exclusive Patent License Agreement, effective as of April 24, 2014, and the Third Amendment to Exclusive Patent
License Agreement, dated as of June 26, 2015 (as so amended, the “Agreement”), between Duke University, a nonprofit
educational and research institution organized under the laws of North Carolina (“DUKE”) having its principal office
in Durham, North Carolina 27708, and Humacyte, Inc., a corporation organized under the laws of North Carolina (“COMPANY”)
with its corporate headquarters and principal office at 7020 Kit Creek Road, Suite 180, Research Triangle Park, NC 27709. All capitalized
terms used herein but not otherwise defined herein shall have the meanings set forth for such terms in the Agreement.

 

WHEREAS, COMPANY has
been engaged in good faith and reasonable commercial efforts to commercialize the PATENT RIGHTS and develop, register, market and
sell LICENSED PRODUCTS, and desires to effect an amendment to the DUE DILIGENCE SCHEDULE.

 

WHEREAS, the Agreement
requires that any change or modification to the Agreement and the DUE DILIGENCE SCHEDULE be set forth in a written instrument executed
by both DUKE and COMPANY.

 

NOW, THEREFORE, in consideration
of the premises and mutual covenants contained herein and in the Agreement, the parties hereby agree as follows:

 

1. The
obligation described in the last bullet of the DUE DILIGENCE SCHEDULE is hereby deleted in its entirety and replaced with the following:

 

		●	[***]

 

2. Section
12.01 of the Agreement is hereby amended to revise the contact information for purposes of the delivery of notices to COMPANY pursuant
to the Agreement as follows:

 

For delivery via the
U.S. Postal Service:

 

Humacyte, Inc.

2525 East North Carolina Highway 54

Durham, North Carolina 27713-2201

Attention: Paul Boyer, Chief Financial Officer

 

cc: (if of a legal nature,
which such copy shall not constitute notice in the case of COMPANY)

 

Covington & Burling LLP

One CityCenter

850 Tenth Street, NW

Washington, DC 20001

Attention: Kerry Burke

 

     

     

    

 

3. Upon
the effectiveness of this Fourth Amendment, each reference in the Agreement to (i) “this Agreement”, “hereunder”,
“hereof’, “herein” or words of like import shall mean and be a reference to the Agreement as amended hereby,
and (ii) to the “DUE DILIGENCE SCHEDULE” shall mean and be a reference to the DUE DILIGENCE SCHEDULE as amended hereby.

 

4. All
terms, conditions and provisions of the Agreement not expressly amended, modified or deleted by this Fourth Amendment shall continue
in full force and effect and are hereby ratified by the parties. This Fourth Amendment is binding on and inures to the benefit
of the parties and their permitted heirs, successors and assigns.

 

5. The
Agreement, together with any exhibits and appendices affixed thereto, all as modified by this Fourth Amendment, constitutes the
entire and exclusive agreement between DUKE and COMPANY with respect to the subject matters hereof and thereof.

 

6. This
Fourth Amendment shall be construed as having been entered into in the State of North Carolina and shall be interpreted in accordance
with and its performance governed by the laws of the State of North Carolina, without regard to any choice-of-law or conflict-of-law
provision that would dictate the application of the law of another jurisdiction.

 

7. This
Fourth Amendment may be executed in multiple counterparts, all of which shall be considered one and the same agreement, and shall
become effective when each party hereto shall have received counterparts hereof signed by each of the other parties hereto. If
any signature is delivered by facsimile transmission or by PDF, such signature shall create a valid and binding obligation of the
party executing (or on whose behalf the signature is executed) with the same force and effect as if such facsimile or PDF signature
were an original thereof.

 

(Signature Page Follows)

 

    2

     

    

 

	
	
        PO Box 12695

        7020 Kit Creek Road, Suite 230

        Research Triangle Park, NC 27709
	 	
        Phone: 919.313.9633

        Fax: 919.313.9634

        www.humacyte.com

 

(Signature Page to Fourth Amendment to
Exclusive Patent License Agreement)

 

IN WITNESS WHEREOF, the
parties have duly executed this Fourth Amendment as of the date first written above.

 

	DUKE UNIVERSITY	 	HUMACYTE, INC.
	 	 	 
	By:	/s/ Robin Resor	 	By:	/s/ Paul A. Boyer
	Name: 	Robin Rasor	 	Name: 	Paul A. Boyer
	Title:	Executive Director	 	Title:	Chief Financial Officer

 

 

3Exhibit 10.10.5

 

FIFTH AMENDMENT TO EXCLUSIVE PATENT LICENSE
AGREEMENT

 

This Fifth Amendment
(this “Fifth Amendment”), effective as of December 31, 2019 (“EFFECTIVE DATE”),
amends the Exclusive Patent License Agreement, effective March 14, 2006, as amended by the First Amendment to Exclusive
Patent License Agreement, effective as of February 25, 2011, the Second Amendment to Exclusive Patent License Agreement, effective
as of April 24, 2014, the Third Amendment to Exclusive Patent License Agreement, dated as of June 26, 2015, and the Fourth Amendment
to Exclusive Patent License Agreement, effective as of January 2, 2018 (as so amended, the “Agreement”), between Duke
University, a nonprofit educational and research institution organized under the laws of North Carolina (“DUKE”) having
its principal office in Durham, North Carolina 27708, and Humacyte, Inc., a corporation organized under the laws of Delaware (“COMPANY”)
with its corporate headquarters and principal office at 2525 East NC Highway 54, Durham, NC 27713. All capitalized terms used herein
but not otherwise defined herein shall have the meanings set forth for such terms in the Agreement.

 

WHEREAS, COMPANY has
been engaged in good faith and reasonable commercial efforts to commercialize the PATENT RIGHTS and develop, register, market and
sell LICENSED PRODUCTS, and desires to effect an amendment to the DUE DILIGENCE SCHEDULE.

 

WHEREAS, the Agreement
requires that any change or modification to the Agreement and the DUE DILIGENCE SCHEDULE be set forth in a written instrument executed
by both DUKE and COMPANY.

 

NOW, THEREFORE, in consideration
of the premises and mutual covenants contained herein and in the Agreement, the parties hereby agree as follows:

 

1. The
obligation described in the last bullet of the DUE DILIGENCE SCHEDULE is hereby deleted in its entirety and replaced with the following:

 

		●	[***]

 

2. The
first sentence of Section 2.02 of the Agreement is hereby deleted in its entirety and replaced with the following:

 

DUKE hereby grants to COMPANY and COMPANY
hereby accepts from DUKE, subject to the terms and conditions of this AGREEMENT, a non- exclusive license to COMPANY and COMPANY
AFFILIATES to DUKE’s rights in KNOW-HOW to use and practice the KNOW-HOW to develop, make, have made, use, market, import,
export, lease, offer for sale, sell, and distribute LICENSED PRODUCTS in and with applications in the FIELD OF USE, and LICENSED
SERVICES for use in the FIELD OF USE in the TERRITORY (“KNOW-HOW LICENSE”) up to and including four (4) years after
the First Commercial Sale of a LICENSED PRODUCT or LICENSED SERVICE. First Commercial Sale is defined as the first sale through
a bona fide arm’s length transaction of any LICENSED PRODUCT or LICENSED SERVICE by COMPANY or COMPANY AFFILIATE excluding
the Sale of a LICENSED PRODUCT or LICENSED SERVICE for use in trials, as a sample, or that is of temporary availability (“First
Commercial Sale”).

 

    

     

    

 

3. Section
3.01 (b) of the Agreement is hereby deleted and replaced with following:

 

Royalty on NET SALES of LICENSED PRODUCTS
and LICENSED SERVICES. At the times and in the manner set forth hereafter, COMPANY will pay royalties to DUKE on the sale of
LICENSED PRODUCTS and LICENSED SERVICES by COMPANY, COMPANY AFFILIATES, and/or SUBLICENSEES to the extent that the manufacture,
use, lease, sale, import, export, performance, and/or provision of each such LICENSED PRODUCT and/or LICENSED SERVICE is covered
or claimed under the claims of one or more VALID CLAIMS, or such LICENSED PRODUCT and/or LICENSED SERVICE incorporates KNOW-HOW.
The running royalty rate for NET SALES of LICENSED PRODUCTS and/or LICENSED SERVICES sold, leased, performed, and/or provided by
the COMPANY, COMPANY AFFILIATES and/or SUBLICENSEES (“RUNNING ROYALTY RATE”) shall be [***] percent ([***]%) until
the last to expire of the VALID CLAIMS and thereafter shall remain [***] percent ([***]%) for the remainder of the term of the
KNOW-HOW LICENSE.

 

4. Section
3.01 (d) of the Agreement is hereby deleted and replaced with the following:

 

Expiration of Royalty Obligations.
The obligation to pay RUNNING ROYALTIES and SUBLICENSE REVENUE ROYALTIES will expire, on a product-by-product and service-by-service
basis, upon the latter of (i) the last to expire of the patents included in the PATENT RIGHTS or (ii) the expiration of the term
of the KNOW-HOW LICENSE (“ROYALTY TERM”).

 

5. Section
10.01 of the Agreement is hereby deleted and replaced with the following:

 

Term. This AGREEMENT shall become effective
upon the EFFECTIVE DATE, and shall remain in full force and effect until the earlier to occur of (i) a TERMINATION EVENT, or (ii)
the expiration of the ROYALTY TERM.

 

6. Section
12.01 of the Agreement is hereby amended to revise the contact information for purposes of the delivery of notices to COMPANY and
DUKE pursuant to the Agreement as follows:

 

COMPANY:

 

    2

     

    

 

For delivery
via the U.S. Postal Service:

 

Humacyte, Inc.

2525 East
NC Highway 54

Durham,
North Carolina 27713-2201

Attention:
Douglas Blankenship, Chief Financial Officer

 

cc: (if
of a legal nature, which such copy shall not constitute notice in the case of COMPANY)

 

Covington
& Burling LLP

One CityCenter

850 Tenth
Street, NW

Washington,
DC 20001

Attention:
Kerry Burke

 

		DUKE:	

 

DUKE
UNIVERSITY Office of Licensing & Ventures

2812
Erwin Road, Suite 406

Durham,
NC 27708

Attn:
[***]

For
delivery via electronic mail

 

[***]

Subject: [***]

 

7. In
consideration for this Fifth Amendment, COMPANY shall pay a one- time fee of [***] Dollars ($[***]) due upon the EFFECTIVE DATE.
Such fee shall be non-refundable and non-creditable against any future payments or royalties due to DUKE.

 

8. Upon
the EFFECTIVE DATE, each reference in the Agreement to (i) “this Agreement”, “hereunder”, “hereof”,
“herein” or words of like import shall mean and be a reference to the Agreement as amended hereby, and (ii) to the
“DUE DILIGENCE SCHEDULE” shall mean and be a reference to the DUE DILIGENCE SCHEDULE as amended hereby.

 

9. All
terms, conditions and provisions of the Agreement not expressly amended, modified or deleted by this Fifth Amendment shall continue
in full force and effect and are hereby ratified by the parties. This Fifth Amendment is binding on and inures to the benefit of
the parties and their permitted heirs, successors and assigns.

 

10.  The
Agreement, together with any exhibits and appendices affixed thereto, all as modified by this Fifth Amendment, constitutes the
entire and exclusive agreement between DUKE and COMPANY with respect to the subject matters hereof and thereof.

 

11. This
Fifth Amendment shall be construed as having been entered into in the State of North Carolina and shall be interpreted in accordance
with and its performance governed by the laws of the State of North Carolina, without regard to any choice-of-law or conflict-of-law
provision that would dictate the application of the law of another jurisdiction.

 

    3

     

    

 

12. This
Fifth Amendment may be executed in multiple counterparts, all of which shall be considered one and the same agreement, and shall
become effective when each party hereto shall have received counterparts hereof signed by each of the other parties hereto. If
any signature is delivered by facsimile transmission or by PDF, such signature shall create a valid and binding obligation of the
party executing (or on whose behalf the signature is executed) with the same force and effect as if such facsimile or PDF signature
were an original thereof.

 

(Signature Page Follows)

 

    4

     

    

 

(Signature Page to
Fifth Amendment to Exclusive Patent License Agreement)

 

IN WITNESS WHEREOF, the parties have duly
executed this Fifth Amendment as of the date first written above.

 

	DUKE UNIVERSITY	 	HUMACYTE, INC.
	 	 	 
	By:	/s/ Robin L. Rasor	 	By:	/s/ Douglas Blankenship
	Name: 	Robin L. Rasor	 	Name: 	Douglas Blankenship
	Title:	Executive Director, Office of Licensing Ventures	 	Title:	Chief Financial Officer

 

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