Document:

EXHIBIT 10.1

                               CYTOGEN CORPORATION

                              AMENDED AND RESTATED
                             1995 STOCK OPTION PLAN

                       (last amended as of June 19, 2001)

1.   Purpose; Effective Date.

     (a) The  purposes  of this Plan are to  further  the  interests  of Cytogen
Corporation  (the  "Company") and its  Subsidiaries by retaining the services of
persons now serving as  officers  and other  employees  and  consultants  of the
Company and its  Subsidiaries,  attracting and retaining the services of persons
capable of serving as officers, employees and consultants of the Company and its
Subsidiaries  and providing  incentives  for such  employees and  consultants to
exert   maximum   efforts  to  promote  the  success  of  the  Company  and  its
Subsidiaries.

     (b) The  effective  date of this  Plan is March  28,  1995.  This Plan will
become  effective  on that date,  subject to approval of the Plan not later than
September  30, 1995 by a majority of the votes cast at a duly held  stockholders
meeting at which a quorum  representing  a majority  of all  outstanding  voting
stock is, either in person or by proxy,  present and voting on the Plan. Nothing
in this Plan  shall  affect  the  rights or  obligations  of  holders of options
granted under any other Company stock option plan.

2.   Definitions.

     Whenever used in this Plan, the following  terms will have the meanings set
forth in this paragraph:

     "Board of Directors" means the Board of Directors of the Company.

     "Code" means the U.S. Internal Revenue Code of 1986, as amended.

     "Committee" means the committee described in paragraph 3.

     "Common  Stock" means the common stock,  par value $. 01 per share,  of the
Company.

     "Date of Grant"  means with  respect  to any Option the date the  Committee
approves  the grant of the Option or such later date as may be  specified by the
Committee as the date the option will become effective.

     "Disinterested   Director"   means  a  member   of  the   Board  who  is  a
"disinterested  person"  within  the  meaning  of  Rule  16b-3(d)(3)  under  the
Securities Exchange Act of 1934, or any successor provision.

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     "Eligible  Consultant" means a consultant providing services to, and who is
not an employee of, the Company or any of its Subsidiaries.

     "Employee"  means  any  person  employed  by  the  Company  or  any  of its
Subsidiaries (including, without limitation, a person employed by the Company or
any of its Subsidiaries who is also an officer or director of the Company or any
of its Subsidiaries).

     "Exercise Price" means with respect to any Option the price per share which
must be paid upon exercise of the Option.

     "Fair Market  Value" means (i) if the Common Stock is traded in a market in
which actual  transactions are reported,  the mean of the high and low prices at
which the Common  Stock is reported to have traded on the  relevant  date in all
markets  on which  trading in the Common  Stock is  reported,  or if there is no
reported sale of the Common Stock on the relevant  date, the mean of the highest
reported bid price and lowest  reported  asked price for the Common Stock on the
relevant date,  (ii) if the Common Stock is Publicly  Traded but only in markets
in which there is no reporting of actual  transactions,  the mean of the highest
reported bid price and the lowest  reported  asked price for the Common Stock on
the relevant  date,  or (iii) if the Common Stock is not  Publicly  Traded,  the
value of a share of Common  Stock as  determined  by the most  recent  valuation
prepared by an independent expert at the request of the Committee.

     "Incentive  Stock  Option"  means any Option  that at the time of the grant
qualifies and is  designated as an incentive  stock option within the meaning of
Section 422 of the Code.

     "Non-Qualified  Option"  means any Option  that is not an  Incentive  Stock
Option.

     "Option" means any Incentive Stock Option or  Non-Qualified  Option granted
under this Plan.

     "Option  Agreement" means an agreement in such form as may be determined by
he Committee,  executed and delivered by the Company to the holder of any Option
with respect to that Option.

     "Outside  Director"  means  a  member  of the  Board  who is not a  current
employee of the Company (or a related  entity),  is not a former employee who is
receiving   compensation  for  prior  services  (other  than  benefits  under  a
tax-qualified  retirement  plan), was not an officer of the Company at any time,
and is not currently receiving remuneration,  either directly or indirectly,  in
any capacity other than as a director.

     "Plan" means the Cytogen Corporation 1995 Stock Option Plan, as amended.

     "Publicly Traded" means, with respect to any class of stock, that the class
of stock  is  required  to be  registered  under  Section  12 of the  Securities
Exchange  Act of 1934,  as  amended,  or that  stock of that class has been sold
within the preceding 12 months in an underwritten public offering.

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     "Subsidiary"  means any  corporation  that,  at the time in  question  is a
subsidiary  corporation  of the Company  within the meaning of section 424(f) of
the Code.

     "Ten Percent Shareholder" means, with respect to the grant of any Option, a
person who at the Date of Grant is the beneficial owner of stock possessing more
than 10% of the  total  combined  voting  power of all  classes  of stock of the
Company.

     "Termination  of  Service"  means (a) the time  when the  employee-employer
relationship between an Employee and the Company ceases to exist for any reason,
or (b) the time  when an  officer  who is not also an  Employee  ceases to be an
officer  of the  Company  for any  reason  or (c)  the  time  when  an  Eligible
Consultant  ceases to be such a consultant  for any reason,  including,  but not
limited to, a termination by resignation,  discharge, death, Total Disability or
retirement.  Any leave of absence  taken with the  consent of the  Company for a
period of not more than 90 days shall not be a  Termination  of  Service,  or if
longer,  so long as the  optionee's  right to  reemployment  with the Company is
guaranteed by contract.  If the period of leave exceeds 90 days and if the right
to reemployment  is not guaranteed by contract,  the Termination of Service will
be deemed to occur on the 91st day of the leave.

     "Total Disability" means inability of an Employee or Eligible Consultant to
engage in any substantial gainful activity by reason of a medically determinable
physical or mental  impairment which can be expected to result in death or which
has lasted or can be expected to last for a  continuous  period of not less than
12 months.  All  determinations  as to the date and extent of  disability  of an
Employee or Eligible Consultant will be made by the Committee.

3.   Administration.

     (a) This Plan shall be administered by a Committee, which shall be composed
of not less than two Outside Directors who are also Disinterested Directors. The
Committee  may, from time to time,  adopt or rescind rules and  regulations  for
carrying out the  provisions  and purposes of this Plan.  Subject to the express
provisions  of this  Plan,  the  Committee  shall  have sole  authority,  in its
absolute  discretion,  to  determine  which  officers,  Employees  and  Eligible
Consultants shall receive Options,  the time when Options shall be granted,  the
terms and  provisions of the Options  (which may differ from one another) and to
do  everything  necessary or  appropriate  to administer  this Plan,  including,
without  limitation,  interpreting  the provisions of this Plan and the Options.
All  determinations  made by the  Committee  with  respect  to this Plan and the
Options shall be final, binding and conclusive.

     (b) No member of the  Committee  shall be liable for any act or omission of
the Committee or any other member of the  Committee,  or for any act or omission
on his own part, in connection with the  administration  of this Plan, unless it
resulted from the member's own willful misconduct.

4.   Persons Eligible to Receive Options.

     (a) Options may be granted  under this Plan only to persons who at the Date
of Grant  either (i) are  officers,  Employees  or Eligible  Consultants  of the

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Company  or any of its  Subsidiaries  or (ii) have  agreed  to become  officers,
Employees  or Eligible  Consultants  of the Company or any of its  Subsidiaries,
and, in either  case,  are  determined  by the  Committee  to be of  substantial
importance to the Company or any of its Subsidiaries.

     (b)  Options  granted to persons  who are not yet  officers,  Employees  or
Eligible  Consultants  at the  Date of  Grant  may not be  exercised  until  the
optionee  has become an  officer,  Employee or  Eligible  Consultant,  and shall
expire if the  optionee  fails to commence  service as an  officer,  Employee or
Eligible Consultant within six months (or such other period as the Committee may
determine) after the Date of Grant.

     (c)  Incentive  Stock  Options  may be  granted  only  to  persons  who are
Employees  at the Date of  Grant,  and only on such  terms  as are  provided  in
paragraphs 6, 7 and 8 hereof.

     (d) No Employee or Eligible Consultant to whom Options may be granted under
this Plan may be granted Options to purchase more than 200,000 shares in any one
calendar year.

5.   Stock Subject to the Plan.

     (a)  Subject to any  adjustment  as provided  in  paragraph  9, the maximum
number of shares of Common Stock as to which  Options may be granted  under this
Plan is 4,502,635  shares reduced by the number of outstanding  options  granted
under the Cytogen  Corporation 1989 Employee Stock Option Plan (the "1989 Plan")
that are exercised  after the effective date of this Plan. If any Option expires
or is cancelled or  surrendered  without being  exercised in full, the number of
shares as to which the Option is not exercised  will once again become shares as
to which  new  Options  may be  granted.  The  Common  Stock  which is issued on
exercise of Options may be authorized  but unissued  shares or shares which have
been issued and reacquired by the Company.

     (b) For  administrative  purposes  only, the Committee  shall  establish an
account  indicating the number of shares of Common Stock as to which Options may
then be granted under this Plan (the "Current  Account"),  and the Committee may
issue  Options  only with respect to the shares of Common  Stock  available  for
grant as set forth in the Current Account. The Current Account shall contain the
number of shares available for grant calculated as follows: (a) 4,502,635, minus
(b) the number of shares of Common Stock  subject to options  granted  under the
1989 Plan that are exercised  after the effective  date of this Plan,  minus (c)
the number of shares of Common  Stock  subject to  outstanding  options  granted
under the 1989 Plan and this Plan, plus (d) the number of shares of Common Stock
subject to outstanding options granted under the 1989 Plan and/or this Plan that
expire, are cancelled or surrendered without being exercised in full.

6.   Grants of Options.

     (a) Subject to paragraph 4(d), the Committee will have complete  discretion
to  determine  when,  and to which  officers  or  other  Employees  or  Eligible
Consultants,  Options are to be granted, the number of shares of Common Stock to
which Options granted to each officer or other Employee or Eligible  Consultant,
will relate,  whether and to what extent Options  granted to an officer or other

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Employee  or  Eligible   Consultant,   will  be  Incentive   Stock   Options  or
Non-Qualified  Options and, subject to the provisions of paragraphs 7 and 8, the
Exercise Price and the term of each Option. The Committee may, in its discretion
at the time of granting the Option,  provide that the Exercise Price may be paid
in cash,  by the surrender of Common Stock,  by an  interest-bearing  promissory
note, or by other means; subject, however, to any requirements of applicable law
which may limit the type or amount of such non-cash consideration. If payment by
promissory note is permitted:  (i) the optionee shall be required to make a cash
payment upon exercise of the Option of not less than 20% of the Exercise  Price;
(ii) the note shall provide for full recourse  against the maker;  and (iii) the
note shall be payable in full prior to its stated  maturity upon the  optionee's
Termination of Service for any reason other than death or Total Disability.

     (b) Any Options which are not  designated  as Incentive  Stock Options when
they are granted will be Non-Qualified Options.

     (c)  Promptly  after the Date of Grant of each  Option,  the Company  shall
cause an Option  Agreement  to be executed  and  delivered  to the holder of the
Option.  The Option  Agreement shall clearly state whether the Option granted is
or is not an Incentive Stock Option.  Separate Option  Agreements  shall be used
for Incentive Stock Options and Non-Qualified Stock Options.

     (d) Except as otherwise  determined  by the  Committee,  and subject to the
requirements  of  applicable  law,  the entire  Exercise  Price  received by the
Company upon the exercise of an option shall  constitute  stated  capital to the
extent of the  aggregate  par value of the Common Stock issued upon  exercise of
the Option.

     (e) Any  Option  granted  under  this  Plan  prior  to the date the Plan is
approved by the Company's stockholders shall not be exercisable unless and until
the Plan is so approved.

7.   Option Provisions.

     (a) Exercise Price. No  consideration  shall be payable by any optionee for
the grant of an Option.  Subject to the  provisions  of  paragraph  7(a)(i)  and
paragraph  8, the  Exercise  Price of each Option will be as  determined  by the
Committee.

          (i) The  Committee  shall not grant any Option with an exercise  price
     that is less than 100% of the Fair Market Value of the underlying  stock on
     the date of grant or reduce the exercise  price of any Option granted under
     the Plan.

     (b) Term.  The term of each Option will be as determined by the  Committee,
but in no event  will the term of an Option be  longer  than ten years  from the
Date of Grant, or five years in the case of an Incentive Stock Option granted to
a Ten Percent Shareholder.  Options may not be exercised before six months after
the Date of Grant.  Options will cease to be exercisable prior to the expiration
of their term under certain  circumstances  as provided in paragraphs 7(f), (g),
and (h).  Subject  to the  foregoing,  and to any  vesting  or other  conditions
imposed at the time it is  granted,  an Option may be  exercised  in whole or in
part at any time, or from time to time, during its term.

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<PAGE>
     (c) Manner of Exercise.  To exercise an Option,  the person  exercising the
Option must deliver to the Company, at its principal office:

          (i) a notice of exercise,  which states the extent to which the Option
     is being exercised;

          (ii) a certified or bank cashier's check in an amount, or Common Stock
     with a Fair Market Value,  equal to the Exercise  Price of the Option times
     the number of shares as to which it is being exercised, or consideration in
     such other form as may be permitted  under the terms on which the Option is
     granted; and

          (iii) a certified  or bank  cashier's  check equal to any  withholding
     taxes the Company is required to pay because of the exercise of the Option.

     The  Committee  may permit an  Employee,  as an  alternative  to making the
     payment  described in clause (iii),  to authorize the Company to withhold a
     sum equal to the withholding  taxes the Company is required to pay from the
     Employee's  salary  and bonus  payments  over a period of not more than six
     months (or such  longer  period as the Company  may  approve).  The date on
     which the Company  receives all the items specified in this subsection will
     be the date on which the Option is exercised to the extent described in the
     notice of election.

     (d) Delivery of Stock  Certificates.  As promptly as  practicable  after an
Option is  exercised,  the Company will deliver to the person who  exercises the
Option certificates,  registered in that person's name,  representing the number
of shares of Common  Stock which were  purchased  by the exercise of the Option.
Each  certificate  may bear a legend to indicate,  if  applicable,  that (i) the
Common Stock  represented by the certificate  was issued in a transaction  which
was not registered under the Securities Act of 1933, as amended, and may only be
sold or  transferred in a transaction  which is registered  under that Act or is
exempt from the registration requirements of that Act, and (ii) the Common Stock
represented by the certificate is subject to the obligation of the holder to pay
any unpaid balance of the Exercise Price (whether  pursuant to a promissory note
or  otherwise),  and/or  that the  Common  Stock is  pledged  to secure  such an
obligation.

     (e)  Nontransferability  of Options.  During the  lifetime of the person to
whom an Option is issued, the Option may be exercised only by that person or his
or her guardian or legal representative.  An Option may not be assigned, pledged
or  hypothecated  in any way, will not be subject to execution,  and will not be
transferable otherwise than by will or the laws of descent and distribution. The
Company will not recognize any attempt to assign, transfer,  pledge, hypothecate
or otherwise  dispose of an Option  contrary to the  provisions of this Plan, or
any levy of any attachment or similar  process upon any Option,  and,  except as
expressly  stated in this Plan,  the Company  will not be required  to, and will
not,  issue  Common  Stock on exercise of an Option to anyone who claims to have
acquired that Option from the person to whom it was granted.

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<PAGE>
     (f)  Termination of Service of Holder of Option Other Than Because of Total
Disability or Death. If there is a Termination of Service of a person to whom an
Option has been  granted,  other than by reason of the  person's  death or Total
Disability,  each  Option  held by the person  may be  exercised  (if  otherwise
exercisable)  until  the  earlier  of (i)  the  end of  the  three-month  period
immediately  following  the  date  of  the  Termination  of  Service,  (ii)  the
expiration  of the term  specified in the Option,  or (iii) such earlier time as
may be determined by the Committee at the time of granting the Option.

     (g) Total  Disability  of Holder of Option.  If there is a  Termination  of
Service of a person to whom an Option  has been  granted by reason of his or her
Total Disability,  each Option held by the person may be exercised (if otherwise
exercisable) until the earlier of (i) the end of the one-year period immediately
following the date of the  Termination  of Service,  (ii) the  expiration of the
term specified in the Option, or (iii) such earlier time as may be determined by
the Committee at the time of granting the Option.

     (h) Death of Holder of Option.  If there is a  Termination  of Service of a
person to whom an Option has been  granted  by reason of his or her death,  or a
former officer or Employee or Eligible Consultant dies following the date of his
or her  Termination  of  Service  but at a time  when an Option  still  would be
exercisable by that person but for the death of the person,  each Option held by
the  person at the time of his or her death may be  exercised  by the  person or
persons  to  whom  the  Option  passed  by will or by the  laws of  descent  and
distribution  (but by no other  persons) until the earlier of (i) the end of the
one-year period immediately following the date of death (or such other period as
may be determined by the Committee at the time of granting the Option), (ii) the
expiration  of the term  specified  in the Option,  or (iii) if the death occurs
after the  Termination  of  Service,  the end of the  period in which the Option
could be exercised under paragraph 7(f) or (g).

     8. Special  Provisions  Relating to Incentive  Stock Options.  No Incentive
Stock  Option may be granted  after March 27,  2005.  The  Exercise  Price of an
Incentive  Stock  Option will be not less than 100% of the Fair Market  Value of
the Common Stock on the Date of Grant of the Option.  An Incentive  Stock Option
may not be granted to a person who, at the time the Option is granted,  is a Ten
Percent  Shareholder,  unless (i) the  Exercise  Price of the Option is at least
110% of the Fair Market  Value of the Common Stock on the Date of Grant and (ii)
the Option by its terms is not  exercisable  after the  expiration of five years
from the Date of Grant.  To the extent  that the  aggregate  Fair  Market  Value
(determined  at the time an  Incentive  Stock  Option is  granted) of the Common
Stock with respect to which Incentive Stock Options are first  exercisable by an
Employee during any calendar year (under this Plan and any other incentive stock
option plans of the Company) exceeds $100,000,  such Options shall be treated as
Non-Qualified  Options.

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9.   Recapitalization.

     (a) The  existence of  outstanding  Options shall not affect in any way the
right or power of the Company or its  stockholders  to make or authorize  any or
all  adjustments,  recapitalizations,  reorganizations  or other  changes in the
Company's capital  structure or its business,  or any merger or consolidation of
the Company,  or any issue of bonds,  debentures,  preferred or prior preference
stock  ahead of or  affecting  the Common  Stock or the rights  thereof,  or the
dissolution or liquidation of the Company, or any sale or transfer of all or any
part of its assets or business or any other corporate act or proceeding, whether
of a similar character or otherwise.  Unless otherwise  determined by the Board,
the  issue  by the  Company  of  shares  of stock of any  class,  or  securities
convertible  into  shares of stock of any class,  for cash or  property,  or for
labor or services  either  upon  direct  sale or upon the  exercise of rights or
warrants to subscribe therefor, or on conversion of shares or obligations of the
Company convertible into such shares or other securities,  shall not affect, and
no adjustment by reason thereof shall be made with respect to, the number, class
or price of shares of Common Stock then subject to outstanding Options.

     (b) If as a result of any (i)  reorganization or liquidation of the Company
or (ii)  reclassification of the Company's capital stock, or (iii) consolidation
or merger of the Company  with or into  another  corporation,  or sale of all or
substantially  all the assets of the Company (a reorganization or liquidation of
the Company or  reclassification  of the Company's  capital stock,  or a merger,
consolidation  or  sale  of the  type  described  in  this  subsection  being  a
"Corporate  Transaction")  while an Option is  outstanding,  the  holders of the
Common  Stock become  entitled to receive  with  respect to their Common  Stock,
securities  or assets other than,  or in addition to, their Common  Stock,  upon
exercise of that Option the holder will receive what the holder would have owned
if the  holder  had  exercised  the  Option  immediately  before  the  Corporate
Transaction which occurred while the Option was outstanding and had not disposed
of  anything  the  holder  would  have  received  as a  result  of that  and all
subsequent Corporate Transactions.

10. Rights of Option Holder.

     (a) The holder of an Option  will not have any rights as a  stockholder  by
reason of holding that Option.  Upon  exercise of an Option,  the holder will be
deemed to acquire the rights of a stockholder when, but not before, the issuance
of Common Stock as a result of the exercise is recorded in the stock  records of
the Company.

     (b)  Nothing in this Plan or in the grant of an Option will confer upon any
Employee  the  right  to  continue  in the  employment  of the  Company  or will
interfere with or restrict in any way the rights of the Company to discharge any
Employee at any time for any reason whatsoever,  with or without cause, nor will
it impose any obligation on the Employee to remain in the employ of the Company.

     11. Laws and Regulations. The obligation of the Company to sell and deliver
shares of Common Stock on exercise of Options  will be subject to the  condition
that legal counsel for the Company be satisfied  that the sale and delivery will
not violate the  Securities  Act of 1933,  as amended,  or any other  applicable
laws,  rules or regulations.

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12.  Withholding of Taxes.

     (a) In  addition  to the  requirement  in  paragraph  7(c) that in order to
exercise  an Option a person  must make a payment to the  Company  or  authorize
withholding in order to enable the Company to pay any withholding taxes due as a
result of the  exercise,  if a person who  exercised an  Incentive  Stock Option
disposes of shares of Common Stock acquired  through  exercise of that Incentive
Stock  Option  either  (i)  within  two  years  after  the  Date of Grant of the
Incentive  Stock Option or (ii) within one year after the issuance of the shares
on exercise of the Incentive  Stock  Option,  the person will notify the Company
promptly of the  occurrence of the event and, if the event was a disposition  of
Common  Stock  acquired on exercise of an  Incentive  Stock  Option,  the amount
realized upon the disposition.

     (b) If,  whether  because of a  disposition  of Common  Stock  acquired  on
exercise of an Incentive Stock Option, or otherwise,  the Company is required to
pay withholding  taxes to any Federal,  state or other taxing  authority and the
Employee  fails to  provide  the  Company  with the funds with which to pay that
withholding tax, the Company may withhold up to 50% of each payment of salary or
bonus to the  Employee  (which  will be in  addition  to any other  required  or
permitted  withholding),  until the Company has been  reimbursed  for the entire
withholding tax it was required to pay.

     (c) The  obligations  contained  in  this  paragraph  12  shall  bind  each
optionee,  and each optionee, by accepting and/or exercising an Option, shall be
deemed to agree to observe and comply with them.

     13.  Reservation of Shares. The Company will at all times keep reserved for
issuance  on  exercise  of  Options  a number  of  authorized  but  unissued  or
reacquired  shares of Common  Stock  equal to the  maximum  number of shares the
Company may be required to issue on exercise of outstanding Options (assuming no
subsequent adjustments under paragraph 9).

     14.  Amendment of the Plan. The Board of Directors may at any time and from
time to time modify or amend this Plan in any respect  effective at any date the
Board of  Directors  determines;  provided,  that  without  the  approval of the
stockholders  of the  Company  the Board of  Directors  may not,  (i)  except as
provided in paragraph 9,  increase the maximum  number of shares of Common Stock
which may be issued on exercise of Options  granted under this Plan; (ii) change
the  categories  of persons  eligible to receive  Options;  (iii)  increase  the
per-optionee  limit  specified  in  paragraph  4(d),  (iv) take any other action
requiring the approval of the  stockholders  of the Company in order to maintain
the exemption available under Rule 16b-3 (or any similar rule) of the Securities
and Exchange  Commission,  or (v) modify the provisions of paragraph 7(a)(i). No
modification  or amendment of this Plan will,  without the consent of the holder
of an  outstanding  Option,  adversely  affect the  holder's  rights  under that
Option.

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     15. Interpretation The Committee shall have the power to interpret the Plan
and to make and amend rules for putting it into effect and  administering it. It
is  intended  that the  Incentive  Stock  Options  granted  under the Plan shall
constitute  incentive  stock  options  within the  meaning of section 422 of the
Code,  that the  Non-Qualified  Options  shall  constitute  property  subject to
federal income tax pursuant to the provisions of section 83 of the Code and that
the Plan shall  qualify  for the  exemption  available  under Rule 16b-3 (or any
similar rule) of the  Securities  and Exchange  Commission.  It is also intended
that all  compensation  income  recognized  by  optionees  as the  result of the
exercise of Options or the  disposition  of Common Stock acquired on exercise of
Options shall be considered performance-based  compensation excludable from such
optionee's  "applicable employee  remuneration" pursuant to section 162(m)(4)(C)
of the Code. The provisions of the Plan shall be interpreted and applied insofar
as possible to carry out such intent.

     16.  Termination of the Plan.  This Plan shall  terminate on March 27, 2005
unless sooner  terminated.  The Board of Directors may suspend or terminate this
Plan at any time or from time to time,  but no such action may adversely  affect
the rights of a person holding an outstanding Option.

                                       10EXHIBIT 10.2

                              CYTOGEN CORPORATION

                  AMENDED AND RESTATED 1999 STOCK OPTION PLAN
                           FOR NON-EMPLOYEE DIRECTORS

1.   Purpose; Effective Date.

     (a) The  purposes  of this Plan are to  further  the  interests  of Cytogen
Corporation  (the "Company") by retaining the services of persons now serving as
non-employee Directors of the Company,  attracting and retaining the services of
persons  capable of serving on the Board of  Directors  of the  Company,  and by
providing  such persons with an incentive  that aligns their  interests with the
interests of the Company's shareholders.

     (b)  This  Plan  will  become  effective  on  approval  of the  Plan by the
affirmative  vote of the majority of shares  present in person or represented by
proxy at a meeting of the  shareholders  of the Company and cast on the proposal
for  approval  of the Plan.

2.   Definitions.

     Whenever used in this Plan, the following  terms will have the meanings set
forth in this Section:

     "Board of Directors" means the Board of Directors of the Company.

     "Cash  Component"  means  director  cash  compensation,  including  but not
limited to annual services fees,  fees payable for board and committee  meetings
attended and fees for committees chaired.

     "Code" means the United States Internal Revenue Code of 1986, as amended.

     "Common  Stock" means the common  stock,  par value $.0l per share,  of the
Company.

     "Compensation  Shares"  means any shares of Common Stock issued to Eligible
Directors  hereunder in payment of such Eligible  Director's  Cash  Component of
compensation.

     "Date of Grant"  means with  respect to any Option the date the Option will
become effective under the provisions of this Plan.

     "Disability"  means  inability  of a Director to engage in any  substantial
gainful  activity  by  reason of a  medically  determinable  physical  or mental
impairment which  reasonably can be expected to last for a continuous  period of
not less than six months.

     "Eligible  Director"  means,  as of any time, a person who is a director of
the Company but is not then an Employee.

<PAGE>
     "Employee"  means any person  employed by the Company  (including,  without
limitation,  a person employed by the Company who is also an officer or director
of the Company).

     "Exchange Act" means the Securities  Exchange Act of 1934, as amended,  and
rules and regulations promulgated thereunder.

     "Exercise Price" means with respect to any Option the price per share which
must be paid upon exercise of the Option.

     "Fair Market  Value" means (i) if the Common Stock is traded in a market in
which actual  transactions are reported,  the average of the high and low prices
at which the Common Stock is reported to have traded on the relevant date in all
markets  on which  trading in the Common  Stock is  reported,  or if there is no
reported sale of the Common Stock on the relevant  date, the mean of the highest
reported bid price and lowest  reported  asked price for the Common Stock on the
relevant date,  (ii) if the Common Stock is Publicly  Traded but only in markets
in which there is no reporting of actual  transactions,  the mean of the highest
reported bid price and the lowest  reported  asked price for the Common Stock on
the relevant  date,  or (iii) if the Common Stock is not  Publicly  Traded,  the
value of a share  of  Common  Stock as  determined  by the  most  recent  annual
valuation  prepared  by an  independent  expert at the  request  of the Board of
Directors.

     "Major Event" means when (i) the Company enters into one or more definitive
agreements to merge or consolidate the Company with or into another corporation,
or to sell or otherwise  dispose of all or  substantially  all of the  Company's
assets,  or to effect any other  transaction,  consolidation  or  reorganization
having similar results or effect; (ii) any person other than the Company makes a
tender or  exchange  offer for more than 50% of Common  Stock  pursuant to which
purchases  of any amount of Common Stock are made;  or (iii) stock  representing
more than 50% of the voting power of the Company is acquired by any person other
than the  Company  in any one or more  transactions  occurring  in any  24-month
period.

     "Option" means any option granted under this Plan.

     "Option Agreement" means an agreement, in such form as may be determined by
the Board of Directors or the  Committee,  executed and delivered by the Company
to the holder of any Option with respect to that option.

     "Option  Shares" means,  with respect to any Option,  the maximum number of
shares of Common  Stock  which may be  acquired  under the  option  prior to its
expiration.

     "Plan" means the Cytogen  Corporation  1999 Directors Stock Option Plan, as
amended.

     "Publicly Traded" means, with respect to any class of stock, that the class
of stock  is  required  to be  registered  under  Section  12 of the  Securities
Exchange  Act of 1934,  as  amended,  or that  stock of that class has been sold
within the preceding 12 months in an underwritten public offering.

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<PAGE>
     "Termination  of Service" means the time when a Director ceases to serve as
a  Director  for  any  reason,   including  without   limitation  by  reason  of
resignation, retirement, removal, death or Disability.

3.   Administration of the Plan.

     (a)  The  Compensation   Committee  of  the  Board  of  Directors  will  be
responsible for the  administration of this Plan. The Committee shall consist of
two or more  non-employee  directors of the Company who meet the  definition  of
"outside  director"  under the  provisions of Section 162(m) of the Code and the
definition of "non-employee  director" under the provisions of the Exchange Act.
No member of the Committee  shall have been within one year prior to appointment
to, or while serving on, the Committee  granted or awarded equity  securities of
the  Company  pursuant  to this or any other plan of the  Company  except to the
extent that participation in any such plan or receipt of any such grant or award
would not adversely  affect the  Committee  member's  status as a  "non-employee
director" or as an "outside director".

     (b) The  Committee  shall  (i)  determine  or  provide  for the  terms  and
conditions of the issuance of Compensation Shares, if so authorized by the Board
of Directors, or grant Agreements, and all election and other forms, which terms
and conditions shall not be inconsistent with this Plan, (ii) interpret the Plan
and (iii) make all other  decisions  relating to the operation of the Plan.  The
Committee  may  adopt  such  rules  or  guidelines  as it deems  appropriate  to
implement the Plan. The Committee's determinations under the Plan shall be final
and binding on all persons.

     (c) No member of the Board of Directors or of any committee of the Board of
Directors shall be liable for any act or omission of the Board or any committee,
or of any other member of the Board or any committee, or for any act or omission
on his own part, in connection  with the  administration  of this Plan unless it
resulted  from the  member's  own willful  misconduct.

 4.  Persons  Eligible to Receive Options and Compensation Shares.

     Options  and  Compensation   Shares  shall  be  granted  only  to  Eligible
Directors.

5.   Stock Subject to the Plan.

     The  maximum  number  of  shares of  Common  Stock as to which  Options  or
Compensation  Shares may be granted or issued under this Plan is 500,000 shares,
subject to  adjustment  as provided in Section 8. If any Option or  Compensation
Share expires or is cancelled,  surrendered or forfeited without being exercised
in full (with  respect to Options),  the number of shares as to which the Option
is not exercised, or Options or Compensation Shares are canceled, surrendered or
forfeited, will once again become shares as to which new Options or Compensation
Shares may be granted.  The Common  Stock  which is issued upon the  exercise of
Options or issued as  Compensation  Shares may be authorized but unissued shares
or shares which have been issued and  reacquired  by the  Company.

                                       3
<PAGE>
6. Grants of Options or Compensation  Shares.

     (a) Each person who is newly-elected a director of the Company at an annual
meeting of the  stockholders  of the Company,  such person having not previously
served as a director  of the  Company  and such  person  then being an  Eligible
Director,  shall, as of the date of such annual meeting, be granted an Option to
purchase  twenty thousand  (20,000)  shares of Common Stock.  In addition,  each
person who is  appointed a director  of the  Company  after the date of the most
recent annual  meeting of the  stockholders  of the Company,  and is an Eligible
Director as of such date,  shall be granted on such date an Option to purchase a
pro rata portion of twenty thousand (20,000) shares of Common Stock,  based upon
the number of full months  remaining from the date of appointment  until the one
year anniversary month of such preceding annual meeting.

     (b) Effective on approval of the Plan by the shareholders,  each person who
is on that date an  Eligible  Director  shall be granted  an Option to  purchase
twenty one thousand (21,000) shares of Common Stock (the "Initial Option").

     (c) Each person who is  appointed a director of the Company  after the date
of approval of the Plan by the  Shareholders  and is an Eligible  Director as of
such date  shall be  granted  an Option to  purchase  a pro rata  portion of ten
thousand  (10,000) shares of Common Stock,  based upon the number of full months
remaining from the date of election until the one year anniversary  month of the
preceding annual meeting, as of the effective date of their appointment.

     (d) On the day following  each annual  meeting of the  stockholders  of the
Company,  commencing  with the 2000 annual  meeting,  each person who is on that
date an Eligible Director and was re-elected at that meeting shall be granted an
Option to purchase 10,000 shares of Common Stock. In addition, a Chairman of the
Board of Directors,  unless the  Compensation  Committee of the Board determines
otherwise, shall receive an additional grant of fifteen thousand (15,000) shares
of Common Stock.

     (e) Eligible  Directors shall receive,  at the sole discretion of and after
formal action by the Board of Directors,  Compensation  Shares in such number of
shares of Common Stock that is equal to each respective Eligible Director's Cash
Component  compensation divided by the Fair Market Value of the Company's Common
Stock as of the date of issuance of such Compensation  Shares, which shall be no
earlier  than the date on  which  the  applicable  Cash  Component  compensation
becomes due and payable by the Company,  subject to the terms and conditions set
forth  herein.  Compensation  Shares  shall not be issued for  services  not yet
rendered by an Eligible Director to the Company.

     (f)  Subject to Section  6(e)  hereof,  Eligible  Directors  shall  receive
Compensation  Shares in lieu of the Cash  Component of such Eligible  Director's
compensation until at least such time as: (i) such Eligible Director owns twenty
thousand  (20,000) shares of the Company's  Common Stock,  excluding  options or
other  rights  to  acquire  shares  of  the  Company's  Common  Stock,   whether
exercisable or unexercisable;  or (ii) if fewer than 20,000 shares are so owned,
such  smaller  number of shares  having a Fair Market  Value of in excess of one
hundred thousand dollars ($100,000),  excluding the value, if any, of options to
purchase Common Stock, whether exercisable or unexercisable,  or other rights to
acquire Common Stock of the Company.

                                       4
<PAGE>
     (g) Upon  achieving  either  of the  milestones  (i) or (ii)  set  forth in
Section  6(f) hereof,  each such  Eligible  Director  may, at his or her option,
elect  to  cease  receiving  his or her  Cash  Component  to  which he or she is
entitled in shares of Common Stock under the Plan; provided,  however, that such
Eligible  Director must make such election by providing  notice of such election
to the Company.

     (h)  Each  Option   provided  for  in  this  Section  6  shall  be  granted
automatically and without further action by the Company,  the Board of Directors
or the Company's  stockholders.  Promptly after the Date of Grant of each Option
provided for in this Section 6, the Company  shall cause an Option  Agreement to
be executed and  delivered to the holder of the Option.  No other Options may be
granted at any time under this Plan.

7.   Option and Compensation  Shares  Provisions.

     (a) Exercise  Price.  The Exercise Price of the Initial Option will be 200%
of the Fair Market Value of the Common Stock on the Date of Grant of the Option.
The Exercise  Price of each Option other than the Initial Option will be 100% of
the Fair  Market  Value of the Common  Stock on the Date of Grant of the Option.
The Committee may not reduce the Exercise  Price of any Option granted under the
Plan.

(b)  Term;  Vesting.

     (i)  No Option  granted under this Plan may be exercised more than 10 years
          after the Date of Grant of the option.

     (ii) Except as provided in Sections  7(b)(iii),  7(f),  7(g) and 7(h),  the
          Initial  Option  shall  become  exercisable  in  one-third  increments
          annually on the first,  second, and third anniversaries of the Date of
          Grant,  and  Options  other  than  the  Initial  Option  shall  become
          exercisable in full on the first anniversary of the Date of Grant.

     (iii)Upon  the  occurrence  of a  Major  Event,  all of the  Option  Shares
          covered by an Option shall become  immediately  available for purchase
          upon exercise of the option,  without regard to the vesting provisions
          of Section 7(b)(ii).

     (c) Exercise of Options.  An Option may be exercised in whole or in part at
any time,  or from time to time,  during its term.  To exercise  an Option,  the
person  exercising  the Option must  deliver to the  Company,  at its  principal
office:

     (i)  a notice of exercise of the Option,  which  states the extent to which
          the option is being exercised; and

     (ii) payment  in full in cash,  which may be  satisfied  by a check,  in an
          amount equal to the  Exercise  Price of the option times the number of
          shares as to which it is being exercised.

                                       5
<PAGE>

    (d) Delivery of Stock  Certificates.  As promptly as  practicable  after an
option is  exercised  or  Compensation  Shares  become  payable  to an  Eligible
Director,  the Company will deliver to the person who exercises the Option or is
owed such  Compensation  Shares,  certificates  registered in that person's name
representing  the number of shares of Common  Stock which were  purchased by the
exercise of the option or grant of  Compensation  Shares in payment for services
rendered.  Each certificate may bear a legend to indicate,  if applicable,  that
the Common Stock  represented  by the  certificate  was issued in a  transaction
which was not registered  under the Securities Act of 1933, as amended,  and may
only be sold or transferred in a transaction  which is registered under that Act
or is exempt from the registration requirements of that Act.

    (e)  Nontransferability

     (i)  Options.  During the lifetime of a person to whom an option is issued,
          the Option may be exercised only by that person or his or her guardian
          or legal  representative.  An Option may not be  assigned,  pledged or
          hypothecated  in any way, will not be subject to  execution,  and will
          not be transferable  otherwise than by will or the laws of descent and
          distribution.  The Company will not  recognize  any attempt to assign,
          transfer,  pledge,  hypothecate  or  otherwise  dispose  of an  option
          contrary to the provisions of this Plan, or any levy of any attachment
          or similar process upon any Option, and, except as expressly stated in
          this Plan,  the Company will not be required  to, and will not,  issue
          Common  Stock on  exercise  of an option to anyone  who claims to have
          acquired that option from the person to whom it was granted.

     (ii) Compensation  Shares.  For one  year  after  the date of  issuance  of
          Compensation Shares to any Eligible Director, such Compensation Shares
          shall not be transferable by such Eligible  Director.  During this one
          year  period,  Compensation  Shares  may not be  assigned,  pledged or
          hypothecated in any way, and will not be  transferable  otherwise than
          by will or the laws of descent and distribution.  The Company will not
          recognize  any attempt to assign,  transfer,  pledge,  hypothecate  or
          otherwise dispose of Compensation Shares contrary to the provisions of
          this Plan, or any levy of any  attachment or similar  process upon any
          Compensation Shares, and, except as expressly stated in this Plan, the
          Company  will not be  required  to, and will not,  remove any  related
          restrictive  legend from the  Compensation  Shares until such one year
          period has expired.  The Compensation  Shares shall bear a restrictive
          legend  evidencing  such  lock-up  (the  "Lock-up  Legend").  Upon the
          expiration of such one year lock-up period, Compensation Share s shall
          become fully  transferable by the holder,  subject to the terms of the
          Securities  Act of 1933,  as amended and state  securities  laws.  The
          Company shall take reasonable  steps to remove the Lock-up Legend from
          the Compensation  Shares within a reasonable time after the expiration
          of  such   period   upon  the   request  of  an   Eligible   Director.
          Notwithstanding such lock-up provision, upon the occurrence of a Major
          Event,  all of the  Compensation  Shares issued  hereunder to Eligible
          Directors  shall be  treated in a like  manner as are the  outstanding
          shares of the Company's Common Stock upon the occurrence of such Major
          Event.

                                       6
<PAGE>
     (f) Termination of Service of Director Holding an Option Other Than Because
of Death or Disability.  Subject to the provisions of Sections 7(b) and 7(h), if
there is a  Termination  of  Service  of a  director  to whom an Option has been
granted,  other  than by  reason  of the  director's  death  or  disability,  or
retirement,  each Option held by the director may be exercised until the earlier
of (x) the end of the  three-month  period  immediately  following  the  date of
Termination of service, or (y) the expiration of the term of the option.

     (g) Death or Disability of Director Holding an Option.  Notwithstanding the
provisions of Section  7(b), if there is a Termination  of Service of a director
to whom an  option  has  been  granted  by  reason  of the  director's  death or
disability,  or a former director dies within three months following the date of
his or her Termination of Service,  each option held by the Director on the date
of the  Director's  Termination  of Service may be exercised  in full (i.e.,  in
respect of up to 100% of the Option shares, regardless of the time elapsed since
the Date of  Grant)  until the  earlier  of (x) the end of the  one-year  period
immediately  following the date of  Termination of service or (y) the expiration
of the term of the option. In the event of an Eligible  Director's death, all of
such person's  outstanding Options will transfer to the maximum extent permitted
by law to such person's designated Beneficiary. Each Eligible Director may name,
from  time to  time,  any  beneficiary  or  beneficiaries  (which  may be  named
contingent ly or  successively)  as his or her  Beneficiary for purposes of this
Plan. Each  designation  shall be on a form  prescribed by the Company,  will be
effective  only when delivered to the Company and when effective will revoke all
prior designations by the Eligible  Director.  If an Eligible Director dies with
no such  beneficiary  designation  in  effect,  such  person's  Options  will be
transferable  by will  or  pursuant  to the  laws of  descent  and  distribution
applicable to such person.

     (h)  Retirement or  Resignation.  If there is a Termination of Service of a
Director by reason of the Director's retirement or resignation at any time after
the  Director  has  reached age 55 with a minimum of three  years'  service as a
non-employee  director,  each  Option  held by the  Director  on the date of the
Director's  Termination of Service may be exercised in full (i.e., in respect of
up to 100% of the Option  Shares,  regardless of the time elapsed since the Date
of Grant)  until the earlier of (x) the end of the five year period  immediately
following the date of  Termination  of Service or (y) the expiration of the term
of the option.

8.   Recapitalization, reorganizations, stock splits and the like.

     (a) The existence of outstanding  Options or Compensation  Shares shall not
affect in any way the right or power of the Company or its  stockholders to make
or authorize any or all adjustments, recapitalizations, reorganizations or other
changes in the Company's  capital  structure or its  business,  or any merger or
consolidation of the Company,  or any issue of bonds,  debentures,  preferred or
prior  preference  stock ahead of or  affecting  the Common  Stock or the rights
thereof,  or the  dissolution  or  liquidation  of the  Company,  or any sale or
transfer of all or any part of its assets or business or any other corporate act
or  proceeding,   whether  of  a  similar  character  or  otherwise.  Except  as
hereinafter  expressly provided,  the issue by the Company of shares of stock of
any class, or securities convertible into shares of stock of any class, for cash
or  property,  or for labor or  services  either  upon  direct  sale or upon the

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<PAGE>
exercise of rights or warrants to subscribe therefor, or on conversion of shares
or obligations o f the Company convertible into such shares or other securities,
shall not affect, and no adjustment by reason thereof shall be made with respect
to,  the  number,  class or price of shares  of Common  Stock  then  subject  to
outstanding options.

     (b) If as a result of any (i)  reorganization or liquidation of the Company
or (ii)  reclassification  of the Company's capital stock,  stock splits,  stock
splits  in  the  form  of   dividends,   reverse   stock   splits,   or  similar
recapitalizations  of the  Company,  or (iii)  consolidation  or  merger  of the
Company with or into another  corporation,  or sale of all or substantially  all
the assets of the Company (a  reorganization  or  liquidation  of the Company or
reclassification  of the Company's capital stock, or a merger,  consolidation or
sale of the type described in this subsection  being a "Corporate  Transaction")
while an Option is outstanding,  the holders of the Common Stock become entitled
to receive with respect to their Common Stock,  securities or assets other than,
or in addition to, their Common  Stock,  upon exercise of that Option the holder
will receive what the holder  would have owned if the holder had  exercised  the
Option immediately  before the first Corporate  Transaction which occurred while
the option was outstan  ding and had not  disposed of anything  the holder would
have  received as a result of that and all  subsequent  Corporate  Transactions.
Compensation Shares shall be adjusted in the same manner as the Company's Common
Stock in all events.

9.   Rights of Option  Holder.

     The holder of an Option will not have any rights as a stockholder by reason
of holding that Option. Upon exercise of an Option, the holder will be deemed to
acquire the rights of a stockholder when, but not before, the issuance of Common
Stock as a result  of the  exercise  is  recorded  in the stock  records  of the
Company.

10.  Laws and Regulations.

     The obligation of the Company to sell and deliver shares of Common Stock on
exercise of options or upon the issuance of Compensation  Shares will be subject
to the condition  that legal counsel for the Company be satisfied  that the sale
and delivery will not violate the  Securities  Act of 1933,  as amended,  or any
other applicable laws, rules or regulations.

11.  Reservation of Shares.

     The Company  will at all times keep  reserved  for  issuance on exercise of
options a number of authorized but unissued or reacquired shares of Common Stock
equal to the  maximum  number of shares the  Company may be required to issue on
exercise of  outstanding  options  (assuming  no  subsequent  adjustments  under
Section 8).

12.  Amendment of the Plan.

     The  Board of  Directors  may at any time and from  time to time  modify or
amend  this Plan in any  respect  effective  at any date the Board of  Directors
determines;  provided,  that  without the  approval of the  stockholders  of the
Company  the Board of  Directors  may not,  (i) except as provided in Section 8,

                                       8
<PAGE>
increase  the  maximum  number of shares of Common  Stock which may be issued on
exercise of Options or the payment of  Compensation  Shares  granted  under this
Plan;  (ii) change the  provisions  of Section 6 or Section 7; (iii)  change the
categories of persons  eligible to receive options or Compensation  Shares under
this Plan; or (iv)  otherwise  materially  increase  (within the meaning of Rule
16b-3  of  the  Exchange  Act)  the  benefits   accruing  under  this  Plan.  No
modification  or amendment of this Plan will,  without the consent of the holder
of an outstanding Option or Compensation  Shares,  adversely affect the holder's
rights  under  that  Option  or  with  respect  to  such  Compensation   Shares.
Notwithstanding approval by shareholde rs, the Board may amend this Plan without
further shareholder approval to add provisions required or enabled by changes to
Rule 16b-3.

13.  Termination of the Plan.

     This Plan will terminate on June 16, 2009,  unless sooner  terminated.  The
Board of Directors  may suspend or terminate  this Plan at any time or from time
to time, but no such action may adversely  affect the rights of a person holding
an outstanding  Option or Compensation  Share. The applicable terms of the Plan,
and any terms and  conditions as applicable  to Options or  Compensation  Shares
granted  prior to such  date,  shall  survive  the  termination  of the Plan and
continue to apply to such Options or Compensation Shares.

                                       9

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