Document:

EX-10.11

 Exhibit 10.11 
 EXECUTION COPY 
 TVAX BIOMEDICAL, LLC 

EMPLOYMENT AGREEMENT 
 THIS EMPLOYMENT AGREEMENT (“Agreement”), dated as of the 15th day of January, 2010, is made by and between TVAX Biomedical, LLC, a Missouri limited liability company
(“Company”), and Rex Wiggins, an individual (“Executive”). 
 RECITALS

 A. Contemporaneously with the execution and delivery of this Agreement, Company is completing the transactions
contemplated in that certain Note and Warrant Purchase Agreement (the “Purchase Agreement”), dated date hereof, among Company and certain purchasers of notes and warrants thereunder; 

B. Executive is actively engaged in the operation and management of Company’s business and has access to its confidential
information and trade secrets; 
 C. The Purchase Agreement provides that Executive shall enter into this Agreement agreeing to
employment and further agreeing not to engage in certain activities competitive with Company; and 
 D. The purchasers under the
Purchaser Agreement would not have entered into the Purchase Agreement and would not consummate the transactions contemplated therein without Executive becoming an employee of Company subject to the terms and conditions of this Agreement and without
the protections afforded by this Agreement to the goodwill, confidential information, trade secrets and business relationships of Company. 
 AGREEMENT 
 In consideration of the mutual premises and the
covenants, conditions, representations and warranties herein contained, the parties hereto agree as follows: 
 1.
Employment. Company hereby agrees to employ the Executive as Chief Operating Officer and Chief Financial Officer of Company, and the Executive hereby agrees to serve in such capacity. Company reserves the right to modify, delete, add,
or otherwise change Executive’s job responsibilities, in its sole discretion, at any time. Executive will perform such other duties, as are assigned to Executive from time to time, provided that such duties are reasonably consistent with the
positions held by Executive. So long as Executive is employed by Company, Executive agrees to devote Executive’s full business time and efforts exclusively on behalf of Company and to competently and diligently discharge Executive’s duties
hereunder. Executive will not be prohibited from engaging in such personal, charitable or other non-employment activities that do not interfere with Executive’s full-time employment hereunder and that do not violate the other provisions of this
Agreement or any employment policies of Company in effect from time-to-time. Executive will comply fully with all policies of Company as are from time to time in effect and applicable to similarly situated employees of Company. 

  
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 2. Salary. During the Employment Period, Company will pay Executive an annual
salary of $117,000 (“Base Salary”), payable in accordance with Company’s ordinary payroll practices. Upon the later of: (a) satisfactory completion of a six to ten person safety pilot study; or (b) the consummation of
private placement investments subsequent to the date hereof (including loans of a term longer than 3 years subordinated to the loans evidenced by the notes issued under the Purchase Agreement) in exchange for securities of Company and grants
received by Company with gross aggregate cash proceeds to Company of at least $1,500,000 (excluding purchases of securities under the Purchase Agreement and the exercise or conversion price for any options, warrants or other convertible securities
outstanding on the date hereof, including the warrants issued under the Purchase Agreement), as determined by Company’s board of managers in its reasonable discretion and the holders of 70% of the outstanding principal amount of the notes
issued under the Purchase Agreement, the Base Salary shall increase to $150,000. If Executive voluntarily waives, reduces or foregoes any Base Salary or other compensation and benefits to reduce Company’s expenses (whether to meet a cash
shortfall or otherwise) such amounts shall be deemed irrevocably waived, Company shall not accrue any obligation or liability for the same nor shall Executive have any right to receive or recoup the same in the future, it being agreed that any such
amounts are permanently and irrevocably forfeited. 
 3. Benefits. During the Employment Period, the Company will
provide Executive the same benefits as are provided to similarly situated employees of Company. 
 4. Expenses.
Company shall reimburse Executive for such ordinary, necessary and reasonable business expenses as are advanced by Executive in the performance of Executive’s duties hereunder; but such expenses shall be substantiated by Executive in writing to
the reasonable satisfaction of the Company. Such reimbursements shall be made no later than the last day of the calendar month following the calendar month in which the reimbursable expense is incurred and the amount of expenses eligible for
reimbursement during a calendar month may not affect the expenses eligible for reimbursement in any other calendar month. 
 5.
Termination. 
 a. “Cause” means: (i) behavior by Executive which in the
determination of the governing board of Company, in its sole discretion, constitutes sexual harassment, discrimination or similar behavior; (ii) Executive’s commission of a felony or a crime involving moral turpitude or the commission of
any other act or omission involving dishonesty or fraud with respect to Company or any of its affiliates or any of their respective customers or suppliers; (iii) conduct by Executive which in the determination of the governing board of Company,
in its sole discretion, tends to bring Company, or any of its affiliates into public disgrace or disrepute; (iv) Executive’s willful failure or Executive’s continued failure (which failure need not be willful) to perform
Executive’s duties hereunder or as otherwise directed by Company or its governing board; (iv) Executive’s gross negligence or willful misconduct with respect to Company or any of its affiliates; (v) any breach of Sections
6 or 7 of this Agreement or any other material term of this Agreement; or (vi) Executive’s repeated absence from work or purported resignation; provided, that for a determination to terminate the employment of Executive
for Cause pursuant to subsection (iv), Company shall provide a written notice of such 

  
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violation to Executive and if Executive fails to remedy such behavior within 10 days of the date of such notice as determined by the governing board of Company in its sole discretion then such
determination of Company to terminate for Cause shall be effective; provided, further, that Executive shall have no right nor shall Company have any obligation to provide such notice or opportunity to cure for any subsequent violation.

 b. “Disability” means a determination by the governing board of Company, in its sole
discretion, based on competent medical authority, that Executive is unable to perform Executive’s duties under this Agreement, which inability continues for a period of 45 successive days or 60 days in any period of 90 consecutive days.
Executive shall submit to all medical exams required by Company. 
 c. “lack of performance by
Executive” shall mean the governing board of Company determined in its sole discretion that Executive has not met the performance standards established for Executive; provided, that for a determination to terminate the employment of
Executive for lack of performance by Executive, Company shall provide a written notice of such determination to Executive and if Executive fails to remedy such performance shortfall within a reasonable period of time after the date of such notice
(but in no event longer than 30 days) as determined by the governing board of Company in its sole discretion then such determination of Company to terminate for lack of performance by Executive shall be effective; provided, further,
that Executive shall have no right nor shall Company have any obligation to provide such notice or opportunity to cure for any subsequent determination. 
 d. Company agrees to employ Executive for a period of three years commencing on the date hereof and ending on third anniversary of the date hereof (“Initial Term”) and for successive one
year periods after the expiration of the Initial Term, unless either Company or Executive provides written notice of nonrenewal at least 30 days prior to the expiration of the Initial Term or any renewal period (the Initial Term and any renewal
period of employment thereafter is referred to as the “Employment Period”); provided, that the Employment Period shall terminate prior to expiration: (i) automatically upon Executive’s death or Disability;
(ii) at the election of Company for any reason or no reason (whether for Cause or without Cause) by giving Executive written notice of the termination date; or (iii) at the election of Company for lack of performance by Executive by giving
Executive written notice at least 90 days in advance of the termination date (the date of any termination hereunder, the “Termination Date”). 
 e. If the Employment Period is terminated by Company without Cause (excluding a termination of the Employment Period by Company for lack of performance by Executive in accordance with subsection
(d)(iii) or the expiration of the Employment Period), Executive shall only be entitled to receive for six months after the Termination Date (“Severance Period”) Executive’s Base Salary as in effect immediately prior to the
Termination Date paid on the same basis as previously paid in addition to Executive’s earned but unpaid Base Salary, benefits, bonuses and other payments or benefits through the Termination Date. 

  
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 f. Except: (i) as expressly provided in subsection (e); or (ii) as
required by applicable law, Executive shall not be entitled to any severance payments or other amounts and all of Executive’s rights to Base Salary, benefits, bonuses and other payments or benefits under this Agreement or otherwise which accrue
or become payable after the termination or expiration of the Employment Period shall cease upon the Termination Date or expiration of the Employment Period (as applicable). All of Executive’s benefits shall cease to be effective immediately as
of the Termination Date or expiration of the Employment Period, as applicable, (except as required by applicable law). Company’s obligation to pay or provide any Base Salary, benefits and bonuses and to make any other payments or provide any
other benefits under this Agreement or otherwise shall terminate automatically as of the Termination Date or expiration of the Employment Period (as applicable), except as expressly provided under subsection (e) and except for the payment of
earned but unpaid Base Salary, benefits, bonuses and other payments or benefits through the Termination Date or expiration of the Employment Period (as applicable). Additionally, if Executive fails to fulfill the full term of Executive’s
employment (other than as a result of Executive’s death or Disability) Executive shall be liable to Company and its owners for such failure and any loss, expense and damage (including diminution in value of the Company and its business and
consequential damages) to Company and its business arising from such failure and shall indemnify Company and its owners from the same. 
 g. Notwithstanding anything to the contrary contained herein and in addition to and not in limitation of all other rights and remedies available to Company, if Executive breaches any of the provisions of
Sections 6 or 7 of this Agreement, Company shall no longer be obligated to pay or provide any Base Salary, benefits, bonuses and to make any other payments or provide any other benefits under this Agreement or otherwise, including any
payments during the Severance Period (if applicable). 
 6. Inventions, Etc. 

a. “Intellectual Property Rights” means all registered and unregistered intellectual property rights
owned or used by Company or any of its affiliates, including all of the following items along with all income, royalties, damages, equitable relief and payments due or payable at any time (including damages, equitable relief and payments for past,
present or future infringements or misappropriations thereof, the right to sue and recover for past infringements or misappropriations thereof and any and all corresponding rights that, now or hereafter, may be secured throughout the world):
(i) patents, patent applications, patent disclosures and inventions (whether or not patentable and whether or not reduced to practice) and any reissue, continuation, continuation-in-part, division, revision, extension or reexamination thereof;
(ii) trademarks, service marks, industrial designs, trade dress, internet domain names and web sites, logos, topographies, trade names and company names, together with all goodwill associated therewith; registered and unregistered copyrights,
copyrightable works and mask works; (iii) all registrations, applications and renewals for any of the foregoing; (iv) trade secrets and confidential information (including ideas, formulae, compositions, know-how, manufacturing and
production processes and techniques, research and development information, drawings, specifications, designs, plans, proposals, technical data, financial, 

  
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business and marketing plans, and customer and supplier lists and related information); (v) computer software and software systems (including data, databases and related documentation);
(vi) other proprietary rights; (vii) licenses or other agreements to or from third parties regarding the foregoing; and (viii) all copies and tangible embodiments of the foregoing (in whatever form or medium). 

b. Executive agrees that all inventions and Intellectual Property Rights conceived of or developed by Executive prior to
the date hereof in connection with any services rendered by Executive to Company or on or after the date hereof during the term of the Executive’s employment with Company or any of its affiliates, whether alone or jointly with others and
whether during working hours or otherwise, which relate to the business or interests of Company or any of its affiliates shall be Company’s exclusive property. Any copyrightable work prepared in whole or in part by Executive will be deemed
“a work made for hire” under Section 201(b) of the 1976 Copyright Act, and the Company shall own all of the rights comprised in the copyright therein. Executive shall: (i) promptly disclose in writing to Company each invention
and Intellectual Property Right conceived or developed by Executive and subject to this Agreement; (ii) assign all rights to such inventions and Intellectual Property Rights to the Company; and (iii) assist Company in every way to obtain
and protect any patents, trademarks or copyrights on such inventions and Intellectual Property Rights (including providing reasonable assistance in securing patent protection and copyright registrations and executing all documents as reasonably
requested by Company, whether such requests occur prior to or after termination of Executive’s employment with Company). Executive hereby irrevocably assigns to Company any rights Executive may have or may acquire in such inventions and
Intellectual Property Rights. Executive hereby irrevocably waives all “moral rights”, all rights under the Visual Artists Rights Act, all rights of privacy and publicity, and the like, in all materials provided to Company or any of its
affiliates with respect to inventions and Intellectual Property Rights. 
 c. As requested by Company from time
to time and upon the termination of Executive’s employment with Company for any reason, Executive shall promptly deliver to Company all copies and embodiments, in whatever form, of all Confidential Information (defined below) and Intellectual
Property Rights in Executive’s possession or within Executive’s control (including written records, notes, photographs, manuals, notebooks, documentation, program listings, flow charts, magnetic media, disks, diskettes, tapes and all other
materials containing any Confidential Information or Intellectual Property Rights) irrespective of the location or form of such material and, if requested by Company, shall provide Company with written confirmation that all such materials have been
delivered to Company. 
 d. Executive hereby warrants and covenants that: (i) Executive’s employment by
Company and execution, delivery and performance of this Agreement do not and shall not result in a breach of the terms, conditions or provisions of any agreement, instrument, order, judgment or decree to which Executive is subject,
(ii) Executive is not a party to or bound by any employment agreement, noncompete agreement or confidentiality agreement with any other person or entity and (iii) upon the execution and delivery of this Agreement by Company, this Agreement
shall be the valid and binding obligation of Executive, enforceable in accordance with its terms. 

  
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 7. Restrictive Covenants. In consideration of Executive’s continuing
employment with Company and the amounts payable to Executive hereunder, Executive agrees that: 
 a. During the
period of Executive’s employment and for two years thereafter (“Non-Compete Period”), the Executive shall not, and shall not allow any of Employee’s affiliates to, engage (whether as an owner, operator, manager, employee,
officer, director, consultant, advisor, representative or otherwise), directly or indirectly, in any endeavor, activity or business anywhere in the world in any case that competes with or proposes to compete with or is or proposed to be
substantially similar in concept, design, format or otherwise to the business of Company as conducted by Company or any of its affiliates during the Non-Compete Period; provided, that this paragraph shall not be construed to prohibit the
ownership of less than 5% of the outstanding stock of any publicly-traded corporation. 
 b. During the
Non-Compete Period, Executive shall not, and shall not allow any of Executive’s affiliates to, directly or indirectly: (i) induce or attempt to induce any employee of Company to leave the employ of Company, or in any way interfere with the
relationship between Company and any employee thereof; (ii) hire directly or through another entity any person who was an employee of Company at any time during the Non-Compete Period; (iii) induce or attempt to induce any customer,
supplier, licensee or other business relation of Company to cease doing business with the Company, or in any way interfere with the relationship between any such customer, supplier, licensee or business relation and Company (including making any
negative statements or communications concerning Company). 
 c. Executive shall not at any time, directly or
indirectly, publicly disparage or make negative, derogatory or defamatory public statements about Company, its affiliates, their respective business activities, or any of their respective directors, officers, members, managers, partners, owners,
employees, affiliates, agents or representatives, to any party. 
 d. At all times, Executive shall treat and
hold as confidential any information concerning Company and its affiliates and their respective businesses that is not already generally available to the public other than as a result of disclosure, directly or indirectly, by Executive, including
financial information, customer lists and other customer information, supplier lists, pricing and cost information, know-how, trade secrets, computer programs and documentation, technical design, formulas, protocols, clinical trials, Intellectual
Property Rights, manufacturing and application information, training information, personnel information, product developments, market information and advertising and business and marketing plans and proprietary design information, in all cases
concerning Company, each of its affiliates and their respective businesses (the “Confidential Information”), refrain from using any of the Confidential Information except in connection with the performance of Executive’s duties
for the sole benefit of Company, and deliver promptly to Company, at the request and option of Company, all 

  
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tangible embodiments (and all copies) of the Confidential Information which are in Executive’s possession or under Executive’s control. If Executive is requested or required (by oral
question or request for information or documents in any legal proceeding, interrogatory, subpoena, civil investigative demand or similar process) to disclose any Confidential Information, Executive shall notify Company promptly of the request or
requirement so that Company may seek an appropriate protective order or waive compliance with the provisions of this paragraph. If, in the absence of a protective order or the receipt of a waiver hereunder, Executive is, on the advice of counsel,
compelled to disclose any Confidential Information to any court, tribunal or other governmental authority or else stand liable for contempt, such party may disclose the Confidential Information thereto; provided, that Executive shall use best
efforts to obtain, at the request of Company, an order or other assurance that confidential treatment shall be accorded to such portion of the Confidential Information required to be disclosed as Company shall designate. 

e. If Executive breaches any of the foregoing provisions of Sections 6 or 7, monetary damages shall not
constitute a sufficient remedy so Company may, in addition to other rights and remedies existing in its favor, apply to any court of law or equity of competent jurisdiction for specific performance and/or injunctive or other relief to enforce or
prevent any violations of the foregoing provisions Sections 6 and 7, in each case without the requirement of posting a bond or proving actual damages. 

f. If the final judgment of a court of competent jurisdiction or arbitrator declares that any term or provision of
Sections 6 or 7 is invalid or unenforceable, the parties hereto agree that the court or arbitrator making the determination of invalidity or unenforceability shall have the power to reduce the scope, duration, or area of the term or
provision, to delete specific words or phrases, or to replace any invalid or unenforceable term or provision with a term or provision that is valid and enforceable and that comes closest to expressing the intention of the invalid or unenforceable
term or provision, and Sections 6 and 7 shall be enforceable as so modified after the expiration of the time within which the judgment or determination may be appealed. 

g. The foregoing provisions of Sections 6 and 7 are reasonable in all respects (including with respect to
subject matter, time period and geographical area) and are necessary to protect Company’s interest in, and value of, its business (including the goodwill inherent therein). Executive has significant responsibility for the creation of such
value. The purchasers under the Purchase Agreement and Company would not have consummated the transactions contemplated hereby without the foregoing provisions. 
 8. Expenses. Except as otherwise expressly provided in this Agreement, each party will pay its own expenses incurred in connection with this Agreement. 

9. Withholding. From any payments due hereunder to Executive from Company, there will be withheld amounts reasonably
believed by Company to be sufficient to satisfy liabilities for federal, state, and local income and earnings taxes and other charges and customary withholdings. Executive remains primarily liable to such authorities for such taxes and charges to
the extent not actually paid by Company. 

  
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 10. Notices. All notices, consents, waivers and other communications under
this Agreement must be in writing and will be deemed to have been duly given: (a) on the 2nd business day after the date of mailing, if delivered by registered or certified mail, postage prepaid; (b) upon delivery, if sent by hand
delivery; (c) upon delivery, if sent by prepaid courier, with a record of receipt; or (d) the next day after the date of dispatch, if sent by cable, telegram, facsimile, telecopy or any other form of electronic transmission, including
electronic mail, (with a copy simultaneously sent by registered or certified mail, postage prepaid, return receipt requested), in each case to the appropriate addresses, telecopier numbers and e-mail addresses set forth below (or to such other
addresses, telecopier numbers or e-mail address as a party may designate by notice to the other parties): 
 If to Executive:

 Rex Wiggins 
 401 Hershel 
 Belton, Missouri 64102 

If to Company: 

TVAX Biomedical, LLC 
 8060 Reeder Street 
 Lenexa, Kansas 66214 

Attention: President 
 Facsimile No.: (913) 492-2243 
 with copies to: 

TVAX Investors, LLC 
 c/o Bryan Cave LLP 
 3500 One Kansas City Place 

1200 Main Street 

Kansas City, Missouri 64105 
 Attention: Robert M. Barnes 
 Facsimile No.: (816) 855-3368 

E-Mail: rmbarnes@bryancave.com 
 11. Waiver. The rights and remedies of the parties to this Agreement are cumulative and not alternative. Neither the failure nor any delay by any party in exercising any right, power or
privilege under this Agreement or the documents referred to in this Agreement will operate as a waiver of such right, power or privilege, and no single or partial exercise of such right, power or privilege will preclude any other or further exercise
of such right, power or privilege or the exercise of any other right, power or privilege. To the maximum extent permitted by applicable law no: (a) claim or right arising out of this Agreement can be discharged by one party, in whole or in
part, by a waiver or renunciation of the claim or right unless in writing signed by the other party; (b) waiver that may be given by a party will be applicable except in the specific instance for which it is given; and (c) notice to or
demand on one party will be deemed to be a waiver of any obligation of such party or of the right of the party giving such notice or demand to take further action without notice or demand as provided in this Agreement or the documents referred to in
this Agreement. 

  
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 12. Entire Agreement and Modification. This Agreement supersedes all prior
agreements between the parties with respect to its subject matter and constitutes a complete and exclusive statement of the terms of the agreement between the parties with respect to its subject matter. This Agreement may not be amended except by a
written agreement executed by the party to be charged with the amendment. 
 13. Assignment. This Agreement and
all of the provisions hereof shall be binding upon and inure to the benefit of the parties hereto and their respective heirs, successors and permitted assigns, but neither this Agreement nor any of the rights, interests or obligations hereunder
shall be assigned by Executive. 
 14. No Attachment. Except as required by applicable law, no right to receive
any amounts under this Agreement shall be subject to anticipation, commutation, alienation, sale, assignment, encumbrance, charge, pledge or hypothecation, or to execution, attachment, levy or similar process or assignment by operation of law, and
any attempt, voluntary or involuntary, to effect any such action shall be null, void and of no effect (except to the extent of any assignment of any rights of Executive to any payments hereunder by will or by the laws of descent and distribution
upon the death of Executive or otherwise by operation of law to Executive’s heirs and representatives). 
 15. Source
of Payments. All payments provided under this Agreement shall be paid in cash from the general funds of Company, and no special or separate fund shall be established and no other segregation of assets shall be made to assure payment. No
affiliate of Company shall be liable for any amounts due hereunder. 
 16. Severability. Whenever possible, each
provision of this Agreement shall be interpreted in such manner as to be effective and valid under applicable law, but if any provision of this Agreement is held to be prohibited by or invalid or unenforceable under applicable law, such provision
shall be ineffective only to the extent of such prohibition or invalidity or unenforceability, without invalidating the remainder of this Agreement, and shall be reformed and enforced to the maximum extent permitted under applicable law. 

17. Section Headings, Construction. The headings of Sections in this Agreement are provided for convenience only and will
not affect its construction or interpretation. All references to “Section” or “Sections” refer to the corresponding Section or Sections of this Agreement. All words used in this Agreement will be construed to be of such gender or
number as the circumstances require. The word “including” does not limit the preceding words or terms. The singular includes the plural and vice versa. The use of the words “or,” “either,” and “any” shall not
be exclusive. The words such as “herein,” “hereinafter,” “hereof,” “hereto” and “hereunder” refer to this Agreement as a whole and not merely to a subdivision in which such words appear unless the
context otherwise requires. 
 18. Governing Law. This Agreement will be governed by the laws of the State of
Missouri without regard to conflicts of law principles. 

  
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 19. Counterparts. This Agreement may be executed in one or more counterparts,
each of which will be deemed to be an original copy of this Agreement and all of which, when taken together, will be deemed to constitute one and the same agreement. 
 20. Representation by Counsel; Interpretation. The parties hereto each acknowledge that each party to this Agreement has been represented by counsel in connection with this Agreement.
Accordingly, any rule of law, or any legal decision that would require interpretation of any claimed ambiguities in this Agreement against the party that drafted it has no application and is expressly waived. 

21. CONSENT TO JURISDICTION; WAIVER OF JURY TRIAL. THE PARTIES AGREE THAT JURISDICTION AND VENUE IN ANY ACTION BROUGHT BY
ANY PARTY PURSUANT TO THIS AGREEMENT SHALL EXCLUSIVELY LIE IN ANY FEDERAL OR STATE COURT LOCATED IN JACKSON COUNTY, MISSOURI. BY EXECUTION AND DELIVERY OF THIS AGREEMENT, EACH PARTY IRREVOCABLY SUBMITS TO THE JURISDICTION OF SUCH COURTS FOR ITSELF
AND IN RESPECT OF ITS PROPERTY WITH RESPECT TO SUCH ACTION. THE PARTIES IRREVOCABLY AGREE THAT VENUE WOULD BE PROPER IN SUCH COURT, AND HEREBY WAIVE ANY OBJECTION THAT SUCH COURT IS AN IMPROPER OR INCONVENIENT FORUM FOR THE RESOLUTION OF SUCH
ACTION. THE PARTIES FURTHER AGREE THAT THE MAILING BY CERTIFIED OR REGISTERED MAIL, RETURN RECEIPT REQUESTED, OF ANY PROCESS REQUIRED BY ANY SUCH COURT SHALL CONSTITUTE VALID AND LAWFUL SERVICE OF PROCESS AGAINST THEM, WITHOUT NECESSITY FOR SERVICE
BY ANY OTHER MEANS PROVIDED BY STATUTE OR RULE OF COURT. THE PARTIES HEREBY WAIVE AND SHALL NOT SEEK JURY TRIAL IN ANY LAWSUIT, PROCEEDING, CLAIM, COUNTERCLAIM, DEFENSE OR OTHER LITIGATION OR DISPUTE UNDER OR IN RESPECT OF THIS AGREEMENT.

 22. Notification of New Employer. If Executive is no longer an employee of Company, Executive consents to
notification by Company to Executive’s new employer or its agents regarding Executive’s rights and obligations under this Agreement. 
 23. American Jobs Creation Act of 2004. It is intended that this Agreement comply in all applicable respects with Sections 409A(a)(2) through (4) of the Internal Revenue Code of 1986,
as it may be amended from time to time, and any rulings, regulations, or other guidelines promulgated under either or both statutes (such statutes, rulings, regulations and other guidelines to be referred to collectively herein as “Section
409A”). This Agreement, and any amendments thereto, shall therefore be interpreted and implemented at all times so as to: (i) ensure compliance with Section 409A; and (ii) avoid a penalty or early taxation of any payment or
benefit under this Agreement. 
 24. Survival. The provisions of this Agreement, specifically including Sections 6
and 7, which by their terms call for performance subsequent to the termination of Executive’s employment, or the termination or expiration of this Agreement, shall so survive the same. 

  
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 25. Company Subsidiaries. For purposes of Sections 6 and 7, the
term “Company” shall include any subsidiary of Company. 
 [The remainder of this page intentionally left
blank.] 

  
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 IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be duly executed
as of the day and year first above written. 
  

			
	COMPANY:
	
	TVAX BIOMEDICAL, LLC
		
	By:	 	 /s/ Gary W.Wood

	Name:	 	Gary W. Wood
	Title:	 	CEO
	
	EXECUTIVE:
	
	 /s/ Rex Wiggins

	Rex Wiggins

  
 12Indenture

 Exhibit 4.1 
 EXECUTION VERSION 
 CORSICANTO LIMITED, as Issuer 

AMARIN CORPORATION PLC, as Guarantor 
 AND 
 WELLS FARGO BANK, NATIONAL ASSOCIATION, as Trustee 

 
  

Indenture 

Dated as of January 9, 2012 
  

 
 3.50%
Exchangeable Senior Notes due 2032 

 TABLE OF CONTENTS 

 

							
	 	 	 	  	Page	 
	
	ARTICLE 1.	  
	DEFINITIONS AND OTHER PROVISIONS OF GENERAL APPLICATION	  
			
	 Section 1.01
	 	 Definitions
	  	 	1	  
	 Section 1.02
	 	 Compliance Certificates and Opinions
	  	 	12	  
	 Section 1.03
	 	 Form of Documents Delivered to Trustee
	  	 	13	  
	 Section 1.04
	 	 Acts of Holders; Record Dates
	  	 	13	  
	 Section 1.05
	 	 Notices, Etc., to Trustee and the Issuer
	  	 	14	  
	 Section 1.06
	 	 Notice to Holders; Waiver
	  	 	14	  
	
	ARTICLE 2.	  
	SECURITY FORMS	  
			
	 Section 2.01
	 	 Forms Generally
	  	 	14	  
	 Section 2.02
	 	 Form of Face of Note
	  	 	14	  
	 Section 2.03
	 	 Form of Reverse of Note
	  	 	18	  
	
	ARTICLE 3.	  
	THE SECURITIES	  
			
	 Section 3.01
	 	 Title and Terms; Payments
	  	 	27	  
	 Section 3.02
	 	 Ranking
	  	 	27	  
	 Section 3.03
	 	 Denominations
	  	 	27	  
	 Section 3.04
	 	 Execution, Authentication, Delivery and Dating
	  	 	27	  
	 Section 3.05
	 	 Temporary Notes
	  	 	28	  
	 Section 3.06
	 	 Registration; Registration of Transfer and Exchange
	  	 	28	  
	 Section 3.07
	 	 Transfer Restrictions
	  	 	29	  
	 Section 3.08
	 	 Expiration of Restrictions
	  	 	31	  
	 Section 3.09
	 	 Mutilated, Destroyed, Lost and Stolen Notes
	  	 	31	  
	 Section 3.10
	 	 Persons Deemed Owners
	  	 	32	  
	 Section 3.11
	 	 Transfer and Exchange
	  	 	32	  
	 Section 3.12
	 	 Cancellation
	  	 	35	  
	 Section 3.13
	 	 CUSIP Numbers
	  	 	35	  
	 Section 3.14
	 	 Payment and Computation of Interest
	  	 	35	  
	 Section 3.15
	 	 Business Day
	  	 	35	  
	
	ARTICLE 4.	  
	PARTICULAR COVENANTS OF THE ISSUER	  
			
	 Section 4.01
	 	 Payment of Principal and Interest
	  	 	35	  
	 Section 4.02
	 	 Maintenance of Office or Agency
	  	 	36	  
	 Section 4.03
	 	 Appointments to Fill Vacancies in Trustee’s Office
	  	 	36	  
	 Section 4.04
	 	 Provisions as to Paying Agent
	  	 	36	  
	 Section 4.05
	 	 Existence
	  	 	37	  
	 Section 4.06
	 	 No Other Indebtedness
	  	 	37	  
	 Section 4.07
	 	 Additional Interest
	  	 	37	  
	 Section 4.08
	 	 Rule 144A
	  	 	38	  
	 Section 4.09
	 	 Resale of Certain Notes
	  	 	38	  
	 Section 4.10
	 	 Commission Filings and Reports
	  	 	38	  
	 Section 4.11
	 	 Book-Entry System
	  	 	39	  

  
 i 

							
	 Section 4.12
	 	 Par Value Limitation
	  	 	39	  
	 Section 4.13
	 	 [Reserved.]
	  	 	39	  
	 Section 4.14
	 	 Stay; Extension and Usury Laws
	  	 	39	  
	 Section 4.15
	 	 Compliance Certificate
	  	 	39	  
	 Section 4.16
	 	 Additional Amounts
	  	 	39	  
	 Section 4.17
	 	 Listing of the Notes
	  	 	41	  
	
	ARTICLE 5.	  
	REDEMPTION	  
			
	 Section 5.01
	 	 Redemption
	  	 	42	  
	 Section 5.02
	 	 Notice of Tax Redemption and Notice of Optional Redemption
	  	 	43	  
	 Section 5.03
	 	 Holder’s Right to Elect
	  	 	44	  
	 Section 5.04
	 	 Effect of Notice of Tax Redemption and Notice of Optional Redemption
	  	 	45	  
	 Section 5.05
	 	 Deposit of Redemption Price
	  	 	45	  
	 Section 5.06
	 	 Notes Redeemed in Part
	  	 	45	  
	
	ARTICLE 6.	  
	[RESERVED]	  
	
	ARTICLE 7.	  
	EXCHANGE	  
			
	 Section 7.01
	 	 Right to Exchange
	  	 	45	  
	 Section 7.02
	 	 Exchange Procedures
	  	 	48	  
	 Section 7.03
	 	 Settlement Upon Exchange
	  	 	49	  
	 Section 7.04
	 	 Certain Provisions Related to ADSs Issued Hereunder
	  	 	53	  
	 Section 7.05
	 	 Adjustment of Exchange Rate
	  	 	53	  
	 Section 7.06
	 	 Adjustments to Exchange Rate upon Exchange In Connection With a Make-Whole Fundamental Change
	  	 	63	  
	 Section 7.07
	 	 Effect of Recapitalization, Reclassification, Consolidation, Merger or Sale
	  	 	65	  
	 Section 7.08
	 	 No Responsibility of Trustee
	  	 	66	  
	 Section 7.09
	 	 Increased Exchange Rate Applicable to Certain Notes Surrendered in Connection with a Tax Redemption
	  	 	66	  
	
	ARTICLE 8.	  
	PURCHASE AT OPTION OF HOLDERS UPON A FUNDAMENTAL CHANGE AND ON AN OPTIONAL PUT REPURCHASE DATE	   
			
	 Section 8.01
	 	 Fundamental Change Permits Holders to Require the Issuer to Repurchase the Notes
	  	 	67	  
	 Section 8.02
	 	 Fundamental Change Notice
	  	 	67	  
	 Section 8.03
	 	 Repurchase at Option of Holders on Repurchase Dates
	  	 	68	  
	 Section 8.04
	 	 [Reserved.]
	  	 	70	  
	 Section 8.05
	 	 Fundamental Change Repurchase Notice
	  	 	70	  
	 Section 8.06
	 	 Withdrawal of Fundamental Change Repurchase Notice or Repurchase Notice
	  	 	71	  
	 Section 8.07
	 	 Effect of Fundamental Change Repurchase Notice or Optional Put Notice
	  	 	71	  
	 Section 8.08
	 	 Notes Repurchased in Whole or in Part
	  	 	72	  
	 Section 8.09
	 	 Covenant to Comply with Securities Laws upon Repurchase of Notes
	  	 	72	  
	 Section 8.10
	 	 Deposit Fundamental Change Repurchase Price or Repurchase Price
	  	 	72	  
	 Section 8.11
	 	 Covenant Not to Repurchase Notes upon Certain Events of Default
	  	 	73	  

  
 ii 

							
	ARTICLE 9.	  
	EVENTS OF DEFAULT; REMEDIES	  
			
	 Section 9.01
	 	 Events of Default
	  	 	73	  
	 Section 9.02
	 	 Acceleration
	  	 	75	  
	 Section 9.03
	 	 Other Remedies
	  	 	76	  
	 Section 9.04
	 	 Sole Remedy for Failure to Report
	  	 	76	  
	 Section 9.05
	 	 Waivers of Past Defaults
	  	 	76	  
	 Section 9.06
	 	 Control By Majority
	  	 	77	  
	 Section 9.07
	 	 Limitation on Suits
	  	 	77	  
	 Section 9.08
	 	 Rights of Holders to Receive Payment and to Exchange
	  	 	77	  
	 Section 9.09
	 	 Collection Suit by Trustee
	  	 	77	  
	 Section 9.10
	 	 Trustee May Enforce Claims Without Possession of Notes
	  	 	78	  
	 Section 9.11
	 	 Trustee May File Proofs of Claim
	  	 	78	  
	 Section 9.12
	 	 Restoration of Rights and Remedies
	  	 	78	  
	 Section 9.13
	 	 Rights and Remedies Cumulative
	  	 	78	  
	 Section 9.14
	 	 Delay or Omission Not a Waiver
	  	 	78	  
	 Section 9.15
	 	 Priorities
	  	 	78	  
	 Section 9.16
	 	 Undertaking for Costs
	  	 	79	  
	
	ARTICLE 10.	  
	MERGER, CONSOLIDATION OR SALE OF ASSETS AND TAX RESIDENCE	  
			
	 Section 10.01
	 	 Issuer and Guarantor May Consolidate on Certain Terms
	  	 	79	  
	 Section 10.02
	 	 Successor to Be Substituted
	  	 	80	  
	 Section 10.03
	 	 . Successor to Be Substituted
	  	 	80	  
	 Section 10.04
	 	 Assumption by Guarantor
	  	 	80	  
	 Section 10.05
	 	 Change of Tax Residence
	  	 	80	  
	
	ARTICLE 11.	  
	THE TRUSTEE	  
			
	 Section 11.01
	 	 Duties and Responsibilities of Trustee
	  	 	80	  
	 Section 11.02
	 	 Notice of Defaults
	  	 	82	  
	 Section 11.03
	 	 Reliance on Documents, Opinions, Etc.
	  	 	82	  
	 Section 11.04
	 	 No Responsibility for Recitals, Etc.
	  	 	83	  
	 Section 11.05
	 	 Trustee, Paying Agents, Exchange Agents or Registrar May Own Notes
	  	 	83	  
	 Section 11.06
	 	 Monies to be Held in Trust
	  	 	83	  
	 Section 11.07
	 	 Compensation and Expenses of Trustee
	  	 	83	  
	 Section 11.08
	 	 Officer’s Certificate as Evidence
	  	 	84	  
	 Section 11.09
	 	 Conflicting Interests of Trustee
	  	 	84	  
	 Section 11.10
	 	 Eligibility of Trustee
	  	 	84	  
	 Section 11.11
	 	 Resignation or Removal of Trustee
	  	 	84	  
	 Section 11.12
	 	 Acceptance by Successor Trustee
	  	 	85	  
	 Section 11.13
	 	 Succession by Merger, Etc.
	  	 	85	  
	 Section 11.14
	 	 Preferential Collection of Claims
	  	 	86	  
	 Section 11.15
	 	 Trustee’s Application for Instructions from the Issuer
	  	 	86	  
	
	ARTICLE 12.	  
	HOLDERS’ LISTS AND REPORTS BY TRUSTEE	  
			
	 Section 12.01
	 	 Company to Furnish Trustee Names and Addresses of Holders
	  	 	86	  
	 Section 12.02
	 	 Preservation of Information; Communications to Holders
	  	 	86	  
	 Section 12.03
	 	 Reports By Trustee
	  	 	87	  

  
 iii

							
	ARTICLE 13.	 
	SATISFACTION AND DISCHARGE	  
			
	 Section 13.01
	 	 Discharge of Liability on Notes
	  	 	87	  
	 Section 13.02
	 	 Deposited Moneys to Be Held in Trust
	  	 	87	  
	 Section 13.03
	 	 Paying Agent to Repay Monies Held
	  	 	87	  
	 Section 13.04
	 	 Repayment to the Issuer
	  	 	87	  
	 Section 13.05
	 	 Reinstatement
	  	 	88	  
	
	ARTICLE 14.	  
	SUPPLEMENTAL INDENTURES	  
			
	 Section 14.01
	 	 Without Consent of Holders
	  	 	88	  
	 Section 14.02
	 	 With Consent of Holders
	  	 	88	  
	 Section 14.03
	 	 Notices of Supplemental Indentures
	  	 	89	  
	 Section 14.04
	 	 Execution of Supplemental Indentures
	  	 	89	  
	
	ARTICLE 15.	  
	GUARANTEE	  
			
	 Section 15.01
	 	 Guarantee
	  	 	90	  
	 Section 15.02
	 	 Execution and Delivery of Guarantee
	  	 	91	  
	 Section 15.03
	 	 Limitation of Guarantor’s Liability; Certain Bankruptcy Events
	  	 	91	  
	 Section 15.04
	 	 Application of Certain Terms and Provisions to the Guarantor
	  	 	91	  
	
	ARTICLE 16.	  
	MISCELLANEOUS	  
			
	 Section 16.01
	 	 Official Acts by Successor Corporation
	  	 	92	  
	 Section 16.02
	 	 Notices
	  	 	92	  
	 Section 16.03
	 	 Official Acts by Successor Corporation
	  	 	93	  
	 Section 16.04
	 	 Certificate and Opinion as to Conditions Precedent
	  	 	93	  
	 Section 16.05
	 	 When Notes Are Disregarded
	  	 	93	  
	 Section 16.06
	 	 Rules by Trustee, Paying Agent and Registrar
	  	 	93	  
	 Section 16.07
	 	 Legal Holidays
	  	 	94	  
	 Section 16.08
	 	 Governing Law
	  	 	94	  
	 Section 16.09
	 	 No Recourse against Others
	  	 	94	  
	 Section 16.10
	 	 Successors
	  	 	94	  
	 Section 16.11
	 	 Multiple Originals
	  	 	94	  
	 Section 16.12
	 	 Benefits of Indenture
	  	 	94	  
	 Section 16.13
	 	 Table of Contents; Headings
	  	 	94	  
	 Section 16.14
	 	 Severability Clause
	  	 	94	  
	 Section 16.15
	 	 Calculations
	  	 	94	  
	 Section 16.16
	 	 Waiver of Jury Trial
	  	 	94	  
	 Section 16.17
	 	 Consent to Jurisdiction
	  	 	95	  
	 Section 16.18
	 	 Force Majeure
	  	 	95	  
	 Section 16.19
	 	 U.S.A. Patriot Act
	  	 	95	  

  
 iv 

 INDENTURE, dated as of January 9, 2012 between Corsicanto Limited, a private limited
company incorporated under the laws of Ireland, and having its principal office at Arthur Cox Building, Earlsfort Terrace, Dublin 2, Ireland, as Issuer (the “Issuer”), Amarin Corporation plc, a company incorporated under the laws of
England and Wales, and having its principal office at 2 Pembroke House, Upper Pembroke Street 28-32, Dublin 2, Ireland, as Guarantor (the “Guarantor”) and Wells Fargo Bank, National Association, a national banking association, as
Trustee (the “Trustee”). 
 RECITALS OF THE ISSUER 

WHEREAS, the Issuer has duly authorized the creation of an issue of 3.50% Exchangeable Senior Notes due 2032 (each a
“Note” and collectively, the “Notes”) guaranteed on a senior unsecured basis by the Guarantor of the tenor and amount hereinafter set forth, and to provide therefor the Issuer has duly authorized the execution and
delivery of this Indenture; and 
 WHEREAS, all things necessary to make the Notes and the Guarantee, when executed by the
Issuer and the Guarantor, respectively, and authenticated and delivered hereunder and duly issued by the Issuer and the Guarantor, respectively, the valid and legally binding obligations of the Issuer and the Guarantor, respectively, and to make
this Indenture a valid and legally binding agreement of the Issuer and the Guarantor, in accordance with the terms of the Notes and the Indenture, have been done. 
 NOW, THEREFORE, THIS INDENTURE WITNESSETH, for and in consideration of the premises and the purchases of the Notes by the Holders thereof, it is mutually agreed, for the benefit of the Issuer and the
equal and proportionate benefit of all Holders of the Notes, as follows: 
 ARTICLE 1. 

DEFINITIONS AND OTHER PROVISIONS OF GENERAL APPLICATION 
 Section 1.01 Definitions. For all purposes of this Indenture, except as otherwise expressly provided or unless the context otherwise requires: 

(a) the terms defined in this Article 1 have the meanings assigned to them in this Article and include the plural as well
as the singular; 
 (b) all accounting terms not otherwise defined herein have the meanings assigned to them in
accordance with GAAP; and 
 (c) the words “herein,” “hereof’ and “hereunder” and
other words of similar import refer to this Indenture as a whole and not to any particular Article, Section or other subdivision. 
 “Act,” when used with respect to any Holder, has the meaning specified in Section 1.04. 
 “Additional Amounts” shall have the meaning specified in Section 4.16. 
 “Additional Interest” means all amounts, if any, payable pursuant to Section 4.07 and Section 9.04 hereof. Unless the context otherwise requires, all references in this
Indenture to interest include Additional Interest, if any. Any express reference to Additional Interest in this Indenture shall not be construed as excluding Additional Interest in any other text where no such express reference is made. 

“Additional Notes” means any Notes (other than the Initial Notes) issued under this Indenture in accordance with
Section 3.01 hereof, with the same terms as the Initial Notes. 
 “Additional Shares” has the meaning
specified in Section 7.06(a). 
 “ADR” means an American Depositary Receipt, evidencing one or more ADSs,
issued pursuant to the Deposit Agreement. 

 “ADS” means an American Depositary Share, issued pursuant to the Deposit
Agreement, representing one Ordinary Share of the Guarantor as of the date of this Indenture and deposited with the ADS Custodian. 
 “ADS Custodian” means Citibank, N.A., with respect to the Deposit Agreement, or any successor thereto. 
 “ADS Depositary” means Citibank, N.A., as depositary for the ADSs. 
 “ADS Price” means, for any Make-Whole Fundamental Change, (i) in the case of a Make-Whole Fundamental Change that is a Cash Merger, the amount of cash paid per ADS in such Make-Whole
Fundamental Change, and (ii) otherwise, the average of the Last Reported Sale Price of the ADS over the 10 consecutive Trading Day period ending on, and including, the Trading Day immediately preceding such Make-Whole Fundamental Change
Effective Date. 
 “Affiliate” of any specified Person means any other Person directly or indirectly
controlling or controlled by or under direct or indirect common control with such specified Person. For the purposes of this definition, “control” when used with respect to any specified Person means the power to direct the management and
policies of such Person, directly or indirectly, whether through the ownership of voting securities, by contract or otherwise; and the terms “controlling” and “controlled” have meanings correlative to the foregoing. 

“Agent Members” has the meaning specified in Section 3.06(b). 

“applicable Exchange Price” means the Exchange Rate in effect at any given time. 

“applicable Exchange Rate” means the Exchange Rate in effect at any given time. 

“Applicable Procedures” means, with respect to any transfer or transaction involving a Global Note or any beneficial
interest therein, the rules and procedures of the Depositary for such Note, in each case to the extent applicable to such transfer or transaction and as in effect from time to time. 

“Applicable Taxes” has the meaning specified in Section 4.16. 

“Averaging Period” has the meaning specified in Section 7.05(e). 

“Bankruptcy Law” means Title 11 of the United States Code (or any successor thereto) or any similar federal or state law
for the relief of debtors. 
 “Bid Solicitation Agent” means, initially, the Trustee. 

“Board of Directors” means either the board of directors of the Issuer or any duly authorized committee of that board.

 “Board Resolution” means a copy of a resolution certified by the Secretary or an Assistant Secretary or the
General Counsel of the Issuer to have been duly adopted by the Board of Directors and to be in full force and effect on the date of such certification, and delivered to the Trustee. 

“Business Day” means any day other than a Saturday, a Sunday or a day on which the Federal Reserve Bank of New York is
authorized or required by law or executive order to close or be closed. 
 “Capital Stock” means any and all
shares, interests, participations, rights or other equivalents (however designated) of corporate stock and, with respect to partnerships, partnership interests (whether general or limited) and any other interest or participation that confers on a
Person the right to receive a share of the profits and losses of, or distributions of assets of, such partnership. 

“Cash Merger” means a Make-Whole Fundamental Change in which the consideration for the ADSs in such Make-Whole
Fundamental Change is comprised entirely of cash. 

  
 2 

 “Cash Settlement” has the meaning specified in Section 7.03(a).

 “Change in Tax Law” shall have the meaning specified in Section 5.01(a). 

“Clause A Distribution” has the meaning specified in Section 7.05(c). 

“Clause B Distribution” has the meaning specified in Section 7.05(c). 

“Clause C Distribution” has the meaning specified in Section 7.05(c). 

“Close of Business” means 5:00 p.m. New York City time. 

“Code” means the Internal Revenue Code of 1986, as amended. 

“Combination Settlement” has the meaning specified in Section 7.03(a). 

“Commission” means the Securities and Exchange Commission, as from time to time constituted, created under the Exchange
Act. 
 “Common Equity” of any Person means the Capital Stock of such Person that is generally entitled
(a) to vote in the election of directors of such Person or (b) if such Person is not a corporation, to vote or otherwise participate in the selection of the governing body, partners, managers or others that will control the management or
policies of such Person. 
 “Company Order” means a written request or order signed in the name of the Issuer
(a) by its Chief Executive Officer, its President, or its Chief Financial Officer, any of its Vice Presidents, its Treasurer, any Assistant Treasurer, its Secretary, any Assistant Secretary or any of its Vice Presidents or (b) any director
of the Board of Directors, and delivered to the Trustee. 
 “Corporate Trust Office” means the office of the
Trustee at which the corporate trust business of the Trustee shall, at any particular time, be principally administered, which office is, at the date as of which this Indenture is dated, located at Wells Fargo Bank, National Association, Corporate
Trust Services – Mac N9311-110, 625 Marquette Ave. South, Minneapolis, MN 55479, Attention: Corsicanto Ltd. Account Manager, or such other address in the United States as the Trustee may designate from time to time by notice to the Holders and
the Issuer, or the principal corporate trust office in the United States of any successor Trustee (or such other address in the United States as such successor Trustee may designate from time to time by notice to the Holders and the Issuer).

 “Custodian” means any receiver, trustee, assignee, liquidator, custodian or similar official under any
Bankruptcy Law. 
 “Daily Exchange Value” means, for any VWAP Trading Day during an Observation Period,
one-twenty fifth (1/25th) of the product of (i) the Exchange Rate in effect on such Trading Day and (ii) the Daily VWAP for such VWAP Trading Day. 
 “Daily Measurement Value” means, for any Observation Period used to calculate the Exchange Obligation for a Note to which Combination Settlement applies, (i) the Specified Dollar
Amount for such Combination Settlement divided by (ii) 25. 
 “Daily Settlement Amount” means, for any
VWAP Trading Day during an Observation Period, (i) an amount of cash equal to the lesser of (x) the Daily Measurement Value for such Observation Period and (y) the Daily Exchange Value for such VWAP Trading Day and, (ii) if the
Daily Exchange Value for such VWAP Trading Day exceeds the Daily Measurement Value for such Observation Period, the Daily Share Amount for such VWAP Trading Day. 

  
 3 

 “Daily Share Amount” means, for any VWAP Trading Day during an Observation
Period on which the Daily Exchange Value exceeds the Daily Measurement Value, the amount equal to (i) the difference between the Daily Exchange Value for such VWAP Trading Day and the Daily Measurement Value, divided by (ii) the
Daily VWAP for such VWAP Trading Day. 
 “Daily Share Cap” means 7.2369 ADSs per $1,000 principal amount of
Notes (or 6.2930 ADS per $1,000 principal amount of Notes if the Initial Purchasers exercise their over-allotment option in full) which is equivalent to the quotient of (i) 19.99% of the number of ADSs and/or Ordinary Shares outstanding
immediately prior to the issuance of the Notes divided by (ii) the product of (A) the aggregate principal amount of Notes outstanding at their initial issuance (expressed in thousands) and (B) the number of VWAP Trading Days in
the Observation Period. To the extent that the Initial Purchasers’ overallotment right granted pursuant to the Purchase Agreement is exercised, but not in full, the Daily Share Cap shall be adjusted to reflect such exercise with such additional
Notes issued included in “the aggregate principal amount of Notes outstanding at their initial issuance” in the preceding equation. 
 “Daily VWAP” means, for any VWAP Trading Day, the per share volume-weighted average price of the ADSs as displayed under the heading “Bloomberg VWAP” on Bloomberg page
AMRN.UQ<equity>AQR (or its equivalent successor if such page is not available) in respect of the period from the scheduled open of trading until the scheduled close of trading of the primary trading session on such VWAP Trading Day (or if such
volume-weighted average price is unavailable, the market value of one ADS on such VWAP Trading Day, determined, using a volume-weighted average method, by a nationally recognized independent investment banking firm retained for this purpose by the
Issuer). The Daily VWAP will be determined without regard to after hours trading or any other trading outside of the regular trading session trading hours. 
 “Default” means any event that is, or with the passage of time or the giving of notice or both would be, an Event of Default. 

“Deposit Agreement” means the deposit agreement dated March 29, 1993, among the Issuer, the ADS Depositary and all
holders from time to time of the ADRs issued thereunder or, if amended or supplemented as provided therein, as so amended or supplemented. 
 “Depositary” means DTC until a successor Depositary shall have become such pursuant to the applicable provisions of this Indenture, and thereafter “Depositary” shall mean such
successor Depositary. 
 “Distributed Property” has the meaning specified in Section 7.05(c). 

“DTC” means The Depository Trust Company. 
 “Event of Default” has the meaning specified in Section 9.01. 
 “Ex-Dividend Date” means the first date on which the ADSs trade on the applicable exchange or in the applicable market, regular way, without the right to receive the issuance, dividend or
distribution in question, from the Guarantor or, if applicable, from the seller of the ADSs on such exchange or market (in the form of due bills or otherwise) as determined by such exchange or market. 

“Exchange Act” means the U.S. Securities Exchange Act of 1934, as amended. 

“Exchange Agent” initially means the Trustee or such other office or agency designated by the Issuer where Notes may be
presented for exchange. 
 “Exchange Consideration” has the meaning specified in Section 7.03(d).

 “Exchange Date” has the meaning specified in Section 7.02(a). 

“Exchange Notice” shall have the meaning specified in Section 7.02(a). 

  
 4 

 “Exchange Obligation” has the meaning specified in Section 7.03(a).

 “Exchange Price” means, per ADS, $1,000 divided by the applicable Exchange Rate. 

“Exchange Rate” means initially 113.4752 ADSs per $1,000 principal amount of Notes, subject to adjustment as set forth
herein. 
 “Excluded Holder” has the meaning specified in Section 5.03. 

“Expiration Date” has the meaning specified in Section 7.05(e). 

“Expiring Rights” has the meaning specified in Section 7.05. 

“Final Exchange Period Start Date” means October 15, 2031. 

“Financial Institution Surrender” has the meaning specified in Section 7.03(d). 

“Financial Institution Surrender Election” has the meaning specified in Section 7.03(d). 

“Freely Tradable” means, with respect to any Notes, that such Notes are eligible to be sold by a Person who is not an
Affiliate of the Issuer or the Guarantor (within the meaning of Rule 144) and has not been an Affiliate of the Issuer or the Guarantor (within the meaning of Rule 144) during the immediately preceding 90 days without any volume or manner
of sale restrictions under the Securities Act. 
 “Free Trade Date” means the date that is one year after the
last date of original issuance of the Notes (taking into account any Notes issued pursuant to the Initial Purchasers’ exercise of its overallotment option pursuant to the Purchase Agreement). 

“Free Transferability Certificate” means a certificate substantially in the form of Exhibit B. 

“Fundamental Change” shall be deemed to have occurred at the time after the Issue Date of the Notes if any of the
following occurs: 
 (1) any “person” or “group” (within the meaning of Section 13(d)
of the Exchange Act), other than the Guarantor or its subsidiaries or its or their employee benefit plans, becomes the direct or indirect ultimate “beneficial owner,” as defined in Rule 13d-3 under the Exchange Act, of the Guarantor’s
Common Equity representing more than 50% of the voting power of the Guarantor’s Common Equity; 
 (2) the
consolidation or merger of the Guarantor with or into any other Person, any merger of another person into the Guarantor, any scheme of arrangement in respect of the Guarantor or any conveyance, transfer, sale, lease or other disposition of all or
substantially all of the Guarantor’s consolidated properties and assets to another person other than to one or more of its wholly-owned subsidiaries; provided that this clause (2) shall not apply to any transaction (A) that does not
result in any reclassification, conversion, exchange or cancellation of the Guarantor’s outstanding Common Equity (other than any conveyance, transfer, sale lease or other disposition of all or substantially all of the Guarantor’s
properties and assets) and (B) pursuant to which holders of the Guarantor’s Common Equity immediately prior to the transaction own, directly or indirectly, in substantially the same proportions vis-à-vis each other as before the
transaction, 50% or more of the total voting power of all shares of Common Equity entitled to vote generally in elections of directors of the continuing or surviving person immediately after the transaction; 

(3) the Guarantor’s shareholders approve any plan or proposal for the liquidation or dissolution of the Guarantor
(other than in a transaction described in clause (2) above); or 

  
 5 

 (4) ADSs (or other Common Equity or ADSs underlying the Notes based on
which the Notes are then exchangeable pursuant to the terms of the indenture) cease to be listed on any of The New York Stock Exchange, The NASDAQ Global Market, The NASDAQ Global Select Market or The NASDAQ Capital Market (or any of their
respective successors); 
 provided, however, that in the case of a transaction or event described in clause
(1) or (2) above, if at least 90% of the consideration received or to be received by holders of the ADSs (excluding cash payments for fractional ADSs) in the transaction or transactions that would otherwise constitute a Fundamental Change
consists of Publicly Traded Securities, and as a result of such transaction or transactions, the Notes become exchangeable based on such Publicly Traded Securities, excluding cash payments for fractional ADSs (subject to settlement in accordance
with Section 7.03), such event shall not be a Fundamental Change and, for the avoidance of doubt, an event that is not considered a Fundamental Change pursuant to this proviso shall not be a Fundamental Change solely because such event
could also be described by clause (1) or (2) above. 
 “Fundamental Change Notice” has the meaning
specified in Section 8.02(a). 
 “Fundamental Change Notice Date” has the meaning specified in
Section 8.02(a). 
 “Fundamental Change Repurchase Date” has the meaning specified in
Section 8.01(c). 
 “Fundamental Change Repurchase Notice” has the meaning specified in
Section 8.05(a)(i). 
 “Fundamental Change Repurchase Price” has the meaning specified in
Section 8.01(b). 
 “GAAP” means generally accepted accounting principles set forth in the opinions and
pronouncements of the Accounting Principles Board of the American Institute of Certified Public Accountants and statements and pronouncements of the Financial Accounting Standards Board or in such other statements by such other entity as have been
approved by a significant segment of the accounting profession, in each case, as in effect in the United States from time to time. 
 “Global Note” means a Note in global form registered in the Register in the name of a Depositary or a nominee thereof. 

“Guarantee” means the full and unconditional guarantee provided by the Guarantor in respect of the Notes as made
applicable to the Notes in accordance with the provisions of Section 15.01 hereof. 
 “Guarantee
Obligations” shall have the meaning specified in Section 15.01. 
 “Guarantor” means the
corporation named as the “Guarantor” in the first paragraph of this Indenture, and, subject to the provisions of Article 10, shall include its successors and assigns. 

“Guarantor’s Board of Directors” means either the board of directors of the Guarantor or any duly authorized
committee of that board. 
 “Holder” means a Person in whose name a Note is registered in the Register.

 “Indenture” means this instrument as originally executed or as it may from time to time be supplemented or
amended by one or more indentures supplemental hereto entered into pursuant to the applicable provisions hereof, including, for all purposes of this instrument and any such supplemental indenture. 

“Initial Notes” has the meaning specified in Section 3.01. 

“Initial Purchasers” means the initial purchasers listed in the pricing term sheet, dated January 4, 2012, related
to the offer and sale of the Initial Notes. 

  
 6 

 “Interest Payment Date” means each January 15 and July 15 of each
year, beginning July 15, 2012. 
 “Issue Date” means the date the Notes are originally issued as set forth
on the face of the Note under this Indenture. 
 “Issuer” means the Person named as the “Issuer” in
the first paragraph of this instrument until a successor Person shall have become such pursuant to the applicable provisions of this Indenture, and thereafter “Issuer” shall mean such successor Person. 

“Last Reported Sale Price” means, for the ADSs (or any other security for which a Last Reported Sale Price must be
determined), on any Trading Day, the closing sale price per ADS (or such other security, as the case may be) or if no closing sale price is reported, the average of the bid and ask prices or, if more than one in either case, the average of the
average bid and the average ask prices, on that date as reported in composite transactions for the principal U.S. securities exchange on which the ADSs (or such other security as the case may be) are listed. If the ADSs (or such other security, as
the case may be) are not listed for trading on a U.S. national or regional securities exchange on the relevant date, the “Last Reported Sale Price” of the ADSs (or such other security, as the case may be) will be the last quoted bid price
for the ADSs (or such other security, as the case may be) in the over-the-counter market on the relevant date as reported by The OTC Markets Group Inc. or a similar organization. If the ADSs (or such other security, as the case may be) are not so
quoted, the “Last Reported Sale Price” will be the average of the mid-point of the last bid and ask prices for the ADSs (or such other security, as the case may be) on the relevant date from each of at least three nationally recognized
independent investment banking firms selected by the Issuer for this purpose, which may include one of the Initial Purchasers. On or after the occurrence of a reorganization event, the Last Reported Sale Price of a Unit of Reference Property will be
determined in accordance with this definition or, if it cannot be so determined, then it will be determined by the Board of Directors in a commercially reasonable manner and in accordance with the procedures described in this Indenture and/or any
applicable supplemental indenture. 
 “Legal Holiday” is a Saturday, a Sunday or other day on which the Federal
Reserve Bank of New York is authorized or required by law or executive order to close or be closed. 
 “Liquidated
Sum” has the meaning specified in Section 7.03(a). 
 “Make-Whole Fundamental Change” means any
transaction or event that would constitute a Fundamental Change pursuant to clause (1), clause (2) or clause (4) of the definition thereof (determined after giving effect to any exceptions or exclusions to such definition, but without
regard to the proviso in clause (2) of the definition thereof). 
 “Make-Whole Fundamental Change Effective
Date” has the meaning specified in Section 7.06(a). 
 “Market Disruption Event” means, if the
ADSs (or any other security for which a Last Reported Sale Price must be determined) are listed for trading on The NASDAQ Global Market or listed on another U.S. national or regional securities exchange, the occurrence or existence during the
one-half hour period ending on the scheduled close of trading on any Trading Day for the ADSs (or such other security, as the case may be) of any material suspension or limitation imposed on trading (by reason of movements in price exceeding limits
permitted by the relevant securities exchange or otherwise) in the ADSs (or such other security, as the case may be) or in any options contracts or futures contracts relating to the ADSs (or such other security, as the case may be). 

“Maturity Date” means January 15, 2032. 
 “Measurement Period” has the meaning specified in Section 7.01(b). 
 “Merger Event” has the meaning specified in Section 7.07(a). 

  
 7 

 “Notes” has the meaning specified in the first paragraph of the Recitals of
the Issuer, and includes any Note or Notes, as the case may be, authenticated and delivered under this Indenture, including any Global Note. The Initial Notes and the Additional Notes shall be governed by the same terms and for purposes of this
Indenture. 
 “Notice of Default” means written notice provided to the Issuer by the Trustee or to the Issuer
and the Trustee by the Holders of not less than 25% in aggregate principal amount of Notes outstanding of a Default by the Issuer or the Guarantor, which notice must specify the Default, demand that it be remedied and expressly state that such
notice is a “Notice of Default.” 
 “Notice of Optional Redemption” shall have the meaning specified
in Section 5.02(a). 
 “Notice of Tax Redemption” shall have the meaning specified in
Section 5.02(a). 
 “Notice of Tax Redemption Election” shall have the meaning specified in
Section 5.03(b). 
 “Observation Period” means, with respect to any Note surrendered for exchange,
(i) if the Exchange Date applicable to Note occurs prior to October 15, 2031, the 25 consecutive VWAP Trading Day period beginning on, and including, the third VWAP Trading Day immediately following such Exchange Date, and (ii) if the
Exchange Date applicable to such Note occurs on or after October 15, 2031, the 25 consecutive VWAP Trading Day period beginning on, and including, the 27th Scheduled Trading Day (or, the immediately following VWAP Trading Day, if such Scheduled
Trading Day is not a VWAP Trading Day) immediately preceding the Maturity Date. 
 “Offering Memorandum” means
the Preliminary Offering Memorandum, dated January 3, 2012, as supplemented by the related pricing term sheet, dated January 4, 2012, relating to the offering and sale of the Initial Notes. 

“Officer” or “officer” shall mean, the Chairman of the Board of Directors, the Chief Executive Officer,
the President, a Vice President (whether or not designated by a number or word or words added before or after the title “Vice President”) or any Director of the Issuer. 

“Officer’s Certificate” means a certificate signed by the Chief Executive Officer, the President, the Chief
Financial Officer, any of the Vice Presidents, the Treasurer, any Assistant Treasurer, the Secretary, any Assistant Secretary, any of the Vice Presidents or any Director of the Issuer, and delivered to the Trustee. 

“Open of Business” means 9:00 a.m., New York City time. 

“Opinion of Counsel” means a written opinion of counsel, who may be external or in-house counsel for the Issuer or the
Trustee. 
 “Optional Put” has the meaning specified in Section 8.03(a). 

“Optional Put Company Notice” has the meaning specified in Section 8.03(c). 

“Optional Put Notice” has the meaning specified in Section 8.03(b). 

“Optional Redemption” has the meaning specified in Section 5.01(b). 

“Optional Redemption Date” means, when used with respect to any Note to be redeemed pursuant to an Optional Redemption ,
the date fixed for such redemption pursuant to this Indenture. 
 “Optional Redemption Price” shall have the
meaning specified in Section 5.01(b). 
 “Ordinary Shares” means ordinary shares of the Guarantor, par
value £0.50 per share, at the date of the Indenture, subject to Section 7.07. 

  
 8 

 “outstanding” when used with reference to Notes, shall, subject to the
provisions of Section 16.05 mean, as of any particular time, all Notes authenticated and delivered by the Trustee under this Indenture, except: 
 (1) Notes theretofore canceled by the Trustee or accepted by the Trustee for cancellation; 
 (2) Notes, or portions thereof, that have become due and payable and in respect of which monies in the necessary amount shall have been deposited in trust with the Trustee or with any Paying Agent (other
than the Issuer or the Guarantor) or shall have been set aside and segregated in trust by the Issuer (if the Issuer shall act as its own Paying Agent); 
 (3) Notes that have been paid pursuant to Section 3.09 and Notes in lieu of which, or in substitution for which, other Notes shall have been authenticated and delivered pursuant to the terms of
Section 3.09 unless proof satisfactory to the Trustee is presented that any such Notes are held by protected purchasers in whose hands such Notes are valid obligations of the Issuer; and 

(4) Notes exchanged pursuant to Article 7 and required to be cancelled pursuant to Section 3.12. 

“Paying Agent” means any Person (including the Issuer) authorized by the Issuer to pay the principal amount of, interest
on, including Additional Interest, the Redemption Price, the Additional Amounts, the Fundamental Change Purchase Price or Repurchase Price of, any Notes on behalf of the Issuer. Wells Fargo Bank, National Association shall initially be the Paying
Agent. 
 “Person” means any individual, corporation, partnership, private limited company, joint venture,
trust, unincorporated organization or government or any agency or political subdivision thereof. 
 “Physical
Notes” means permanent certificated Notes in registered form issued in denominations of integral $200,000 principal amount and integral multiples of $1,000 in excess thereof. 

“Physical Settlement” has the meaning specified in Section 7.03(a). 

“principal amount” of a Note means the principal amount as set forth on the face of the Note. 

“Publicly Traded Securities” means shares of Capital Stock traded on The New York Stock Exchange, The NASDAQ Global
Market, The NASDAQ Global Select Market or The NASDAQ Capital Market (or their respective successors), or, with respect to a transaction that otherwise would be a Fundamental Change, which will be so traded when issued or exchanged in connection
with such transaction. 
 “Purchase Agreement” means that certain Purchase Agreement, dated January 3,
2012, among the Issuer, the Guarantor and the representatives of the Initial Purchasers, on behalf of the Initial Purchasers. 

“Qualified Institutional Buyer” or “QIB” shall have the meaning specified in Rule 144A. 

“record date” means, with respect to any dividend, distribution or other transaction or event in which the holders of
the Common Equity (or other applicable security) have the right to receive any cash, securities or other property or in which the Common Equity (or other applicable security) is exchanged for or exchanged into any combination of cash, securities or
other property, the date fixed for determination of holders of the Common Equity (or other applicable security) entitled to receive such cash, securities or other property (whether such date is fixed by the Board of Directors or a duly authorized
committee thereof, statute, contract or otherwise). 
 “Redemption Date” means the date fixed for Tax
Redemption and/or Optional Redemption, as the case may be, pursuant to this Indenture. 
 “Redemption Price”
means the price fixed for Tax Redemption and/or Optional Redemption, as the case may be, pursuant to this Indenture. 

  
 9 

 “Redemption Reference Date” means, for any exchange of Notes in connection
with a Tax Redemption, the date 30 days prior to the applicable Redemption Date. 
 “Redemption Reference
Price” means, for any exchange of Notes in connection with a Tax Redemption, the average of the Last Reported Sale Prices of the ADSs over the ten consecutive VWAP Trading Day period ending on, and including, the applicable Redemption
Reference Date. The Board of Directors will make appropriate adjustments, in its good faith determination, to account for any adjustment to the Exchange Rate that becomes effective, or any event requiring an adjustment to the Exchange Rate where the
Ex-Date of the event occurs, during such ten consecutive Trading Day period. 
 “Reference Property” has the
meaning specified in Section 7.07. 
 “Register” and “Registrar” have the respective
meanings specified in Section 3.06. 
 “Regular Record Date” means, with respect to the payment of
interest on the Notes (including Additional Interest, if any) Close of Business on January 1 or July 1, as the case may be, immediately preceding the relevant Interest Payment Date. 

“Relevant Taxing Jurisdiction” has the meaning specified in Section 4.16. 

“Reporting Default” has the meaning specified in Section 9.04(a). 

“Repurchase Date” has the meaning specified in Section 8.03(a). 

“Repurchase Price” has the meaning specified in Section 8.03(a). 

“Resale Restriction Termination Date” has the meaning specified in Section 3.08(b)(ii). 

“Restricted Global Note” has the meaning specified in Section 3.08(b)(i). 

“Restricted Note” has the meaning specified in Section 3.07(a)(i). 

“Restricted Stock” has the meaning specified in Section 3.07(b)(i). 

“Restricted Stock Legend” means a legend substantially in the form set forth in Exhibit A hereto. 

“Rule 144” means Rule 144 under the Securities Act (including any successor rule thereto), as the same may be amended
from time to time. 
 “Rule 144A” means Rule 144A under the Securities Act (including any successor rule
thereto), as the same may be amended from time to time. 
 “Rule 144A Information” has the meaning specified in
the Notes. 
 “Scheduled Trading Day” means a day that is scheduled to be a Trading Day on the primary U.S.
national or regional securities exchange or market on which the ADSs (or any other security for which a Last Reported Sale Price must be determined) are listed or admitted for trading. If the ADSs (or such other security, as the case may be) are not
so listed or admitted for trading, “Scheduled Trading Day” means a “Business Day.” 
 “Securities
Act” means the U.S. Securities Act of 1933, as amended, and the rules and regulations of the Commission promulgated thereunder. 
 “Settlement Method” has the meaning specified in Section 7.03(a). 
 “Share Price” has the meaning specified in Section 7.09(c). 

  
 10 

 “Significant Subsidiary” shall have the meaning given to such term in Rule
1-02(w) of Regulation S-X under the Exchange Act as in effect on the Issue Date of the Notes. 
 “Specified Dollar
Amount” has the meaning specified in 7.03(b)(v). 
 “Spin-Off” has the meaning specified in
Section 7.05(c). 
 “Subsidiary” means, with respect to the Guarantor, any corporation, association,
partnership or other business entity of which more than 50% of the total voting power of shares of Capital Stock or other interests (including partnership interests) entitled (without regard to the occurrence of any contingency) to vote in the
election of directors, managers, general partners or trustees thereof is at the time owned or controlled, directly or indirectly, by (i) the Guarantor; (ii) the Guarantor and one or more Subsidiaries of the Guarantor; or (iii) one or
more Subsidiaries of the Guarantor. 
 “Tax Redemption” shall have the meaning specified in
Section 5.01(a). 
 “Tax Redemption Date” means, when used with respect to any Note to be redeemed
pursuant to a Tax Redemption, the date fixed for such Tax Redemption pursuant to this Indenture. 
 “Tax Redemption
Price” shall have the meaning specified in Section 5.01(a). 
 “Trading Day” means a Scheduled
Trading Day on which (i) trading in the ADSs (or any other security for which a Last Reported Sale Price must be determined) generally occurs on The NASDAQ Global Market or, if the ADSs (or such other security, as the case may be) are not then
listed on The NASDAQ Global Market, on the principal other U.S. national or regional securities exchange on which the ADSs (or such other security, as the case may be) are then listed or, if the ADSs (or such other security, as the case may be) are
not then listed on a U.S. national or regional securities exchange, on the principal other market on which the ADSs (or such other security, as the case may be) are then traded, and (ii) there is no Market Disruption Event. If the ADSs are not
so listed or traded, “Trading Day” means “Business Day.” 
 “Trading Price” of the Notes on
any date of determination means the average of the secondary market bid quotations obtained by the Bid Solicitation Agent for $1.0 million principal amount of Notes at approximately 3:30 p.m., New York City time, on such determination date from
three independent nationally recognized securities dealers selected by the Issuer, which may include one of the Initial Purchasers; provided, however, that if three such bids cannot reasonably be obtained by the Bid Solicitation Agent but two such
bids are obtained, then the average of the two bids shall be used, and if only one such bid can reasonably be obtained by the Bid Solicitation Agent, that one bid shall be used. If the Bid Solicitation Agent cannot reasonably obtain at least one bid
for $1.0 million principal amount of Notes from a nationally recognized securities dealer, then the Trading Price per $1,000 principal amount of Notes will be deemed to be less than 98% of the product of the Last Reported Sale Price of the ADSs and
the applicable Exchange Rate. If the Issuer does not so instruct the Bid Solicitation Agent to obtain bids when required, or the Bid Solicitation Agent fails to solicit bids when required, the Trading Price per $1,000 principal amount of the Notes
will be deemed to be less than 98% of the product of the Last Reported Sale Price of the ADSs and the applicable Exchange Rate on each day the Issuer fails to do so. 
 “Transfer Taxes” shall have the meaning specified in Section 7.02(e). 
 “Trust Indenture Act” means the Trust Indenture Act of 1939, as amended, as it was in force at the date of execution of this Indenture. 

“Trust Officer” shall mean, when used with respect to the Trustee, any officer within the corporate trust department of
the Trustee, including any vice president, assistant vice president, assistant secretary, assistant treasurer, trust officer or any other officer of the Trustee who customarily performs functions similar to those performed by the Persons who at the
time shall be such officers, respectively, or to whom any corporate trust matter is referred because of such person’s knowledge of and familiarity with the particular subject and who shall have direct responsibility for the administration of
this Indenture. 

  
 11 

 “Trustee” means the Person named as the “Trustee” in the
first paragraph of this Indenture until a successor Trustee shall have become such pursuant to the applicable provisions of this Indenture, and thereafter “Trustee” shall mean such successor Trustee. 

“U.S.” means the United States of America. 
 “Unit of Reference Property” has the meaning set forth in Section 7.07(a). 
 “Valuation Period” has the meaning set forth in Section 7.05(c). 
 “Vice President” means any vice president, whether or not designated by a number or a word or words added before or after the title “vice president.” 

“VWAP Market Disruption Event” means (i) a failure by the primary U.S. national or regional securities exchange or
market on which the ADSs are listed or admitted to trading to open for trading during its regular trading session or (ii) the occurrence or existence, prior to 1:00 p.m., New York City time, on any Scheduled Trading Day for the ADSs for more
than a one half-hour period in the aggregate during regular trading hours, of any suspension or limitation imposed on trading (by reason of movements in price exceeding limits permitted by the relevant securities exchange or otherwise) in the ADSs
or in any options contracts or future contracts relating to the Ordinary Shares or the ADSs. 
 “VWAP Trading
Day” means a day on which (i) there is no VWAP Market Disruption Event and (ii) trading in the ADSs generally occurs on The NASDAQ Global Market or, if the ADSs are not then listed on The NASDAQ Global Market, on the primary other
U.S. national or regional securities exchange on which the ADSs are then listed or, if the ADSs are not then listed on a U.S. national or regional securities exchange, on the principal other market on which the ADSs are then listed or admitted for
trading. If the ADSs are not so listed or admitted for trading, “VWAP Trading Day” means a “Business Day.” 

Section 1.02 Compliance Certificates and Opinions. Upon any application or request by the Issuer to the Trustee to take any
action under any provision of this Indenture, the Issuer shall furnish to the Trustee such certificates and opinions as may be required pursuant to Section 16.04. Each (a) an Officer’s Certificate stating that, in the opinion of the
signers, all conditions precedent, if any, provided for in the Indenture relating to the proposed action have been complied with; and (b) an Opinion of Counsel stating that all such conditions precedent relating to the proposed action have been
complied with. 
 Every certificate or opinion with respect to compliance with a condition or covenant provided for in this
Indenture shall include: 
 (a) a statement that each individual signing such certificate or opinion has read
such covenant or condition and the definitions herein relating thereto; 
 (b) a brief statement as to the
nature and scope of the examination or investigation upon which the statements or opinions contained in such certificate or opinion are based; 
 (c) a statement that, in the opinion of each such individual, such individual has made such examination or investigation as is necessary to enable such individual to express an informed opinion as to
whether or not such covenant or condition has been complied with; and 
 (d) a statement as to whether, in the
opinion of each such individual, such condition or covenant has been complied with. 
 In giving such Opinion of Counsel,
counsel may rely as to factual matters on an Officers Certificate or certificates of public officials. 

  
 12 

 Section 1.03 Form of Documents Delivered to Trustee. In any case where several
matters are required to be certified by, or covered by an opinion of, any specified Person, it is not necessary that all such matters be certified by, or covered by the opinion of, only one such Person, or that they be so certified or covered by
only one document, but one such Person may certify or give an opinion with respect to some matters and one or more other such Persons as to other matters, and any such Person may certify or give an opinion as to such matters in one or several
documents. 
 Any certificate or opinion of an officer of the Issuer may be based, insofar as it relates to legal matters, upon
a certificate or opinion of, or representations by, counsel, unless such officer knows, or in the exercise of reasonable care should know, that the certificate or opinion or representations with respect to the matters upon which his certificate or
opinion is based are erroneous. Any such certificate or Opinion of Counsel may be based, insofar as it relates to factual matters, upon a certificate or opinion of, or representations by, an officer or officers of the Issuer stating that the
information with respect to such factual matters is in the possession of the Issuer, unless such counsel knows, or in the exercise of reasonable care should know, that the certificate or opinion or representations with respect to such matters are
erroneous. 
 Where any Person is required to make, give or execute two or more applications, requests, consents, certificates,
statements, opinions or other instruments under this Indenture, they may, but need not, be consolidated and form one instrument. 
 Section 1.04 Acts of Holders; Record Dates. 
 (a) Any
request, demand, authorization, direction, notice, consent, waiver or other action provided by this Indenture to be given or taken by Holders may be embodied in and evidenced by one or more instruments of substantially similar tenor signed by such
Holders in person or by their agents duly appointed in writing and, except as herein otherwise expressly provided, such action shall become effective when such instrument or instruments are delivered to a Trust Officer of the Trustee and, where it
is hereby expressly required, to the Issuer. Such instrument or instruments (and the action embodied therein and evidenced thereby) are herein sometimes referred to as an “Act” of the Holders signing such instrument or instruments.
Proof of execution of any such instrument or of a writing appointing any such agent shall be sufficient for any purpose of this Indenture and (subject to Section 11.01) conclusive in favor of the Trustee and the Issuer, if made in the manner
provided in this Section. 
 (b) The fact and date of the execution by any Person of any such instrument or
writing may be proved by the affidavit of a witness of such execution or by a certificate of a notary public or other officer authorized by law to take acknowledgments of deeds, certifying that the individual signing such instrument or writing
acknowledged to him the execution thereof. Where such execution is by a signer acting in a capacity other than his individual capacity, such certificate or affidavit shall also constitute sufficient proof of his authority. The fact and date of the
execution of any such instrument or writing, or the authority of the Person executing the same, may also be proved in any other manner which the Trustee reasonably deems sufficient. 

(c) The Issuer may, in the circumstances permitted by this Indenture, fix any day as the record date for the purpose of
determining the Holders entitled to give or take any request, demand, authorization, direction, notice, consent, waiver or other action, or to vote on any action, authorized or permitted to be given or taken by Holders. If not set by the Issuer
prior to the first solicitation of a Holder made by any Person in respect of any such action, or, in the case of any such vote, prior to such vote, the record date for any such action or vote shall be the 30th day (or, if later, the date of the most
recent list of Holders required to be provided pursuant to Section 12.01) prior to such first solicitation or vote, as the case may be. With regard to any record date, only the Holders on such date (or their duly designated proxies) shall be
entitled to give or take, or vote on, the relevant action. 
 (d) The ownership of Notes shall be proved by the
Register. 
 (e) Any request, demand, authorization, direction, notice, consent, waiver or other Act of the
Holder of any Note shall bind every future Holder of the same Note and the Holder of every Note issued 

  
 13 

 
upon the registration of transfer thereof or in exchange therefor or in lieu thereof in respect of anything done, omitted or suffered to be done by the Trustee or the Issuer in reliance thereon,
whether or not notation of such action is made upon such Note. 
 Section 1.05 Notices, Etc., to Trustee and the
Issuer. Any request, demand, authorization, direction, notice, consent, waiver or Act of Holders or other document provided or permitted by this Indenture to be made upon, given or furnished to, or filed with: 

(a) the Trustee by any Holder or by the Issuer shall be sufficient for every purpose hereunder if made, given, furnished
or filed in writing (including telecopy and, in the case of notices with respect to Global Notes, electronic transmission) to or with the Trustee at its applicable Corporate Trust Office; or 

(b) the Issuer by the Trustee or by any Holder shall be sufficient for every purpose hereunder (unless otherwise herein
expressly provided) if in writing (including telecopy and, in the case of notices with respect to Global Notes, electronic transmission) and mailed, first-class postage prepaid, to the Issuer addressed to it at the address of its principal office
specified in the first paragraph of this instrument, with a copy to the address specified in Section 15.02, or at any other address previously furnished in writing to the Trustee by the Issuer, Attention: Directors. 

Section 1.06 Notice to Holders; Waiver. Where this Indenture provides for notice to Holders of any event, such notice shall
be sufficiently given (unless otherwise herein expressly provided) if in writing (including telecopy and, in the case of notices with respect to Global Notes, electronic transmission) and mailed, first-class postage prepaid, to each Holder affected
by such event, at such Holder’s address as it appears in the Register, not later than the latest date (if any), and not earlier than the earliest date (if any), prescribed for the giving of such notice. In any case where notice to Holders is
given by mail, neither the failure to mail such notice, nor any defect in any notice so mailed, to any particular Holder shall affect the sufficiency of such notice with respect to other Holders. Where this Indenture provides for notice in any
manner, such notice may be waived in writing by the Person entitled to receive such notice, either before or after the event, and such waiver shall be the equivalent of such notice. Waivers of notice by Holders shall be filed with the Trustee, but
such filing shall not be a condition precedent to the validity of any action taken in reliance upon such waiver. 
 Whenever
under this Indenture the Trustee is required to provide any notice by mail, in all cases the Trustee may alternatively provide notice by overnight courier or by facsimile, with confirmation of transmission. 

ARTICLE 2. 

SECURITY FORMS 

Section 2.01 Forms Generally. The Notes and the Trustee’s certificates of authentication shall be in substantially the
forms set forth in this Article, with such appropriate insertions, omissions, substitutions and other variations as are required or permitted by this Indenture, and may have such letters, numbers or other marks of identification and such legends or
endorsements placed thereon as may be required to comply with the rules of any securities exchange or Depositary therefor, the Code and regulations thereunder, or as may, consistently herewith, be determined by the Officer or Officers executing such
Notes, as evidenced by their execution thereof. 
 The Notes shall initially be issued in the form of permanent Global Notes in
registered form in substantially the form set forth in this Article. The aggregate principal amount of the Global Notes may from time to time be increased or decreased by adjustments made on the records of the Trustee, as FAST agent for the
Depositary, as hereinafter provided. 
 Section 2.02 Form of Face of Note. 

NO AFFILIATE (AS DEFINED IN RULE 144 UNDER THE SECURITIES ACT) OF THE ISSUER AND/OR THE GUARANTOR OR PERSON THAT HAS BEEN AN AFFILIATE
(AS DEFINED IN RULE 

  
 14 

 
144 UNDER THE SECURITIES ACT) OF THE ISSUER AND/OR THE GUARANTOR DURING THE IMMEDIATELY PRECEDING NINETY DAYS MAY PURCHASE, OTHERWISE ACQUIRE OR HOLD THIS NOTE OR A BENEFICIAL INTEREST HEREIN.

 [Include the following legend for Global Notes only (the “Global Notes
Legend”):] 
 [THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER
REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO TRANSFER OF THIS SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF
ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. 

UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY (“DTC”), A NEW YORK
CORPORATION, TO THE ISSUER OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND
ANY PAYMENT IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL IN AS MUCH AS THE REGISTERED
OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN.] 
 [Include the following legend on all Notes that are
Restricted Notes (the “Restricted Notes Legend”):] 
 [THE SALE OF
THIS NOTE HAS NOT BEEN REGISTERED UNDER THE U.S. SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, THIS NOTE AND ANY AMERICAN DEPOSITARY SHARES ISSUABLE UPON EXCHANGE OF THIS NOTE (AND ANY BENEFICIAL INTEREST
HEREIN OR THEREIN) MAY NOT BE OFFERED, RESOLD, PLEDGED OR OTHERWISE TRANSFERRED, EXCEPT IN ACCORDANCE WITH THE FOLLOWING SENTENCE. BY ITS ACQUISITION HEREOF OR A BENEFICIAL INTEREST HEREIN, THE ACQUIRER: 

 

	 	(1)	REPRESENTS THAT IT AND ANY ACCOUNT FOR WHICH IT IS ACTING IS A “QUALIFIED INSTITUTIONAL BUYER” (WITHIN THE MEANING OF RULE 144A UNDER THE SECURITIES ACT)
AND THAT IT EXERCISES SOLE INVESTMENT DISCRETION WITH RESPECT TO EACH SUCH ACCOUNT; AND 

  

	 	(2)	AGREES FOR THE BENEFIT OF THE ISSUER AND/OR THE GUARANTOR THAT IT WILL NOT OFFER, SELL, PLEDGE OR OTHERWISE TRANSFER THIS NOTE OR ANY BENEFICIAL INTEREST HEREIN
PRIOR TO THE RESALE RESTRICTION TERMINATION DATE (AS DEFINED BELOW), EXCEPT: 

  

	 	(A)	TO THE ISSUER, THE GUARANTOR OR ANY SUBSIDIARY THEREOF; 

  

	 	(B)	PURSUANT TO A REGISTRATION STATEMENT THAT HAS BECOME EFFECTIVE UNDER THE SECURITIES ACT; 

 

	 	(C)	TO A PERSON THAT YOU REASONABLY BELIEVE TO BE A QUALIFIED INSTITUTIONAL BUYER IN COMPLIANCE WITH RULE 144A UNDER THE SECURITIES ACT; OR 

 

	 	(D)	UNDER ANY OTHER AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT (INCLUDING, IF AVAILABLE, THE EXEMPTIONS PROVIDED BY REGULATION S AND
RULE 144 UNDER THE SECURITIES ACT). 

  
 15 

 THE “RESALE RESTRICTION TERMINATION DATE” MEANS THE DATE THAT IS THE LATER OF:
(X) TWELVE MONTHS AFTER THE LAST ORIGINAL ISSUANCE DATE OF THE ISSUER’S 3.50% EXCHANGEABLE SENIOR NOTES DUE 2032 (INCLUDING THE LAST DATE OF ISSUANCE OF ADDITIONAL NOTES PURSUANT TO THE EXERCISE OF THE INITIAL PURCHASERS’ OPTION TO
PURCHASE ADDITIONAL NOTES) OR SUCH SHORTER PERIOD OF TIME AS PERMITTED BY RULE 144 UNDER THE SECURITIES ACT OR ANY SUCCESSOR PROVISION THERETO; AND (Y) SUCH LATER DATE, IF ANY, AS MAY BE REQUIRED BY APPLICABLE LAW. PRIOR TO ANY TRANSFER
PURSUANT TO THE FOREGOING CLAUSE (2)(D), THE ISSUER, THE GUARANTOR AND THE TRUSTEE RESERVE THE RIGHT TO REQUIRE THE DELIVERY OF SUCH CERTIFICATIONS, LEGAL OPINIONS OR OTHER INFORMATION AS THE ISSUER OR THEY MAY REASONABLY REQUIRE AND MAY RELY UPON
TO CONFIRM THAT SUCH TRANSFER IS BEING MADE PURSUANT TO AN EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT.] 
 3.50% Exchangeable Senior Notes due 2032 
  

			
	 No. [    ]
	  	U.S. $[            ]

  

			
	CUSIP NO.	  	[220480 AA5]
	ISIN NO.	  	[US220480AA50]

 Corsicanto Limited, a limited liability company incorporated under the laws of Ireland (herein called the
“Issuer”), which term includes any successor corporation under the Indenture referred to on the reverse hereof), for value received hereby promises to pay to
[                    ], or registered assigns, the principal sum of [            ] UNITED
STATES DOLLARS (U.S. $[                ]) (which amount may from time to time be increased or decreased by adjustments made on the records of the Trustee, as custodian
for the Depositary, in accordance with the rules and procedures of the Depositary and in accordance with the below referred Indenture) on January 15, 2032. The principal amount of Physical Notes and interest thereon, as provided on the reverse
hereof, shall be payable at the Corporate Trust Office and at any other office or agency maintained by the Issuer for such purpose. The Paying Agent will pay principal of any Global Note and interest thereon, as provided on the reverse hereof, in
immediately available funds to The Depository Trust Company or its nominee, as the case may be, as the registered holder of such global note, on each Interest Payment Date, Redemption Date, Fundamental Change Purchase Date, Repurchase Date or other
payment date, as the case may be. The Notes will be fully and unconditionally guaranteed by Amarin Corporation plc (the “Guarantor”), on a senior unsecured basis, in accordance with the provisions of Article 15 of the Indenture.

 Reference is made to the further provisions of this Note set forth on the reverse hereof, including, without limitation,
provisions giving the Holder the right to exchange this Note into ADSs of the Guarantor and to the ability and obligation of the Issuer to purchase this Note upon certain events, in each case, on the terms and subject to the limitations referred to
on the reverse hereof and as more fully specified in the Indenture. Such further provisions shall for all purposes have the same effect as though fully set forth at this place. Capitalized terms used but not defined herein shall have such meanings
as are ascribed to such terms in the Indenture. In the case of any conflict between this Note and the Indenture, the provisions of the Indenture shall control. 
 This Note shall not be valid or become obligatory for any purpose until the certificate of authentication hereon shall have been manually signed by the Trustee or a duly authorized authenticating agent
under the Indenture. 

  
 16 

 IN WITNESS WHEREOF, the Issuer has caused this instrument to be duly executed. 

 

							
	SIGNED AND DELIVERED for and on behalf of and as the deed of CORSICANTO LIMITED by its lawfully appointed attorney PATRICK JOSEPH O’SULLIVAN in the
presence of:	 		 	  

		 		 	PATRICK JOSEPH O’SULLIVAN
	  
	 		 	
	(Witness’ Signature)	 		 	
			
	  
	 		 	
			
	  
	 		 	
	(Witness’ Address)	 		 	
			
	  
	 		 	
	(Witness’ Occupation)	 		 	
			
	Dated:	 		 	
			
	TRUSTEE’S CERTIFICATE OF AUTHENTICATION	 		 	
	 WELLS FARGO BANK, NATIONAL ASSOCIATION
 as Trustee, certifies that this is one of the Notes described in the within-named Indenture.
	 		 	
				
	By:	 	  
	 		 	
		 	Authorized Signatory	 		 	

  
 17 

 Section 2.03 Form of Reverse of Note. 

CORSICANTO LIMITED 
 3.50% Exchangeable Senior Notes due 2032 
 This Note is one of a duly
authorized issue of Notes of the Issuer, designated as its 3.50% Exchangeable Senior Notes due 2032 (the “Notes”), all issued or to be issued under and pursuant to an Indenture dated as of January 9, 2012 (the
“Indenture”), among the Issuer, Amarin Corporation plc, as Guarantor (the “Guarantor”) and Wells Fargo Bank, National Association, as Trustee (the “Trustee”), to which Indenture and all indentures
supplemental thereto reference is hereby made for a description of the rights, limitations of rights, obligations, duties and immunities thereunder of the Trustee, the Issuer, the Guarantor and the Holders of the Notes. The Indenture provides that
Additional Notes may be issued thereunder, if certain conditions are met. 
 Interest. The Notes will bear interest at a
rate of 3.50% per year. Interest on the Notes will accrue from, and including, January 9, 2012, or from the most recent date to which interest has been paid or duly provided for. Interest will be payable semiannually in arrears on each
Interest Payment Date, beginning July 15, 2012. Pursuant to the Indenture, in certain circumstances, the Holders of Notes shall be entitled to receive Additional Interest. 

Interest will be paid to the person in whose name a Note is registered at the Close of Business on the January 1 or July 1
(whether or not such date is a Business Day), as the case may be, immediately preceding the relevant Interest Payment Date. Interest on the Notes will be computed on the basis of a 360-day year composed of twelve 30-day months. 

Interest will cease to accrue on a Note in the circumstances provided in the Indenture. 

Ranking. The Notes and the guarantee of the Guarantor constitute a general unsecured and unsubordinated obligation of the Issuer
and the Guarantor, respectively. 
 Redemption at the Option of the Issuer. No sinking fund is provided for the Notes.
Prior to January 19, 2017, the Issuer may not redeem the notes at its option other than in connection with a Change in Tax Law that results in Additional Amounts becoming due and payable in respect to payments and/or deliveries on the Notes.
Upon the occurrence of a Change in Tax Law, the Issuer may elect to redeem the Notes, in whole but not in part, on the Redemption Date at a Redemption Price specified in the Indenture, subject to the Holder’s right to elect to have all or
certain portions specified in the Indenture of such Holder’s Notes surrendered for exchange or otherwise not so redeemed. On or after January 19, 2017, the Issuer may redeem for cash all or a portion of the notes at the Redemption Price
specified in the Indenture. 
 Purchase at the Option of the Holder Upon a Fundamental Change or Upon the Exercise of
Optional Put. Subject to the terms and conditions of the Indenture, the Issuer shall become obligated, at the option of the Holder, to repurchase the Notes if a Fundamental Change occurs or, if the Holder exercises the Optional Put rights, on
January 19, 2017, January 19, 2022 or January 19, 2027, as the case may be, at a repurchase price specified in the Indenture. 
 Exchange. Subject to and upon compliance with the provisions of the Indenture (including without limitation the conditions of exchange of this Note set forth in Article 7 thereof), the Holder
hereof has the right, at its option, during certain periods and upon the occurrence of certain conditions specified in the Indenture, to exchange the principal amount hereof or a certain portion specified in the Indenture of such principal amount
into ADSs at the applicable Exchange Rate. The Exchange Rate (and equivalent Exchange Price) are set forth in the Indenture and subject to adjustment in certain events described in the Indenture. Upon exchange, the Issuer will deliver cash, ADSs or
a combination of cash and ADSs as set forth in the Indenture. No fractional ADS will be issued upon any exchange, but a payment in cash will be made, as provided in the Indenture, in respect of any fraction of an ADS which would otherwise be
issuable upon the surrender of any Notes for exchange. Notes in respect of which a Holder is exercising its right to require repurchase on a Fundamental Change Purchase Date or Repurchase Date may be exchanged only if such Holder withdraws the
related election to exercise such right in accordance with the terms of the Indenture. 

  
 18 

 In the event of a deposit or withdrawal of an interest in this Note, including an exchange,
transfer, repurchase, redemption or exchange of this Note in part only, the Trustee, as custodian of the Depositary, shall make an adjustment on its records to reflect such deposit or withdrawal in accordance with the rules and procedures of the
Depositary. 
 Acceleration of Maturity. Subject to certain exceptions in the Indenture, if an Event of Default shall
occur and be continuing, the principal amount plus interest through such date on all the Notes may be declared due and payable in the manner and with the effect provided in the Indenture. 

Supplemental Indentures with Consent of Holders; Waiver of Past Defaults. The Indenture permits, with certain exceptions as
therein provided, the amendment thereof and the modification of the rights and obligations of the Issuer and the Guarantor and the rights of the Holders of the Notes under the Indenture at any time by the Issuer and the Trustee with the consent of
the Holders of not less than a majority in aggregate principal amount of the outstanding Notes. The Indenture also contains provisions permitting the Holders of specified percentages in aggregate principal amount of the outstanding Notes, on behalf
of the Holders of all the Notes, to waive compliance by the Issuer and the Guarantor with certain provisions of the Indenture and certain past Defaults under the Indenture and their consequences. Any such consent or waiver by the Holder of any
provision of or applicable to this Note shall be conclusive and binding upon such Holder and upon all future Holders of this Note and of any Note issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or
not notation of such consent or waiver is made upon this Note. 
 Registration of Transfer and Exchange. As provided in
the Indenture and subject to certain limitations therein set forth, the transfer of this Note is registrable in the Register, upon surrender of this Note for registration of transfer at the office or agency of the Issuer specified in accordance with
the Indenture, duly endorsed by, or accompanied by a written instrument of transfer in form satisfactory to the Issuer and the Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing, and thereupon one or more new
Notes, of authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees. 
 No service charge shall be made for any such registration of transfer or exchange, but the Issuer and the Registrar may require payment of a sum sufficient to cover any tax or other governmental charge
payable in connection therewith. 
 Prior to due presentment of this Note for registration of transfer, the Issuer, the
Guarantor, the Trustee and the Registrar and any agent of the Issuer or the Trustee may treat the Person in whose name this Note is registered as the owner hereof for all purposes, whether or not this Note be overdue, and neither the Issuer, the
Guarantor, the Trustee nor any such agent shall be affected by notice to the contrary. 
 Denominations. The Notes are
issuable only in registered form in denominations of $200,000 and any integral multiple of $1,000 in excess thereof, as provided in the Indenture and subject to certain limitations therein set forth. Notes are exchangeable for a like aggregate
principal amount of Notes of a different authorized denomination, as requested by the Holder surrendering the same. 
 This
Note and any claim, controversy or dispute arising under or related to this Note shall be governed by, and construed in accordance with, the laws of the State of New York (without regard to the conflicts of laws provisions thereof). 

All terms used in this Note that are defined in the Indenture shall have the meanings assigned to them in the Indenture. 

  
 19 

 NOTATION OF GUARANTEE 

The Guarantor listed below (hereinafter referred to as the “Guarantor,” which term includes any successors or assigns under the
Indenture, dated the date hereof, among the Guarantor, the Issuer (defined below) and Wells Fargo Bank, National Association, as trustee (the “Indenture”)), has irrevocably and unconditionally guaranteed on a senior basis the Guarantee
Obligations (as defined in Section 15.01 of the Indenture), which include (i) the due and punctual payment and/or full performance of the principal of, Additional Amounts with respect to, Exchange Obligations with respect to, and interest
on, the 3.50% Exchangeable Senior Notes due 2032 (the “Notes”) of Corsicanto Limited, a private limited company incorporated under the laws of Ireland (the “Issuer”), whether at maturity, by acceleration, upon redemption, upon
required repurchase, upon exchange or otherwise, the due and punctual payment of interest on the overdue principal, Additional Amounts and Exchange Obligations and (to the extent permitted by law) interest on any interest on the Notes, and the due
and punctual performance of all other obligations of the Issuer, to the Holders or the Trustee all in accordance with the terms set forth in Article 15 of the Indenture, and (ii) in case of any extension of time of payment or renewal of any
Notes or any such other obligations, that the same shall be promptly paid in full when due or performed in accordance with the terms of the extension or renewal, whether at maturity, by acceleration, call for redemption, upon a repurchase or
otherwise. 
 The obligations of the Guarantor to the Holders and to the Trustee pursuant to this Guarantee and the Indenture
are expressly set forth in Article 15 of the Indenture and reference is hereby made to such Indenture for the precise terms of this Guarantee. 
 No past, present or future trustee, officer, employee, incorporator or shareholder (direct or indirect) of the Guarantor (or any such successor entity), as such, shall have any liability for any
obligations of the Guarantor under this Guarantee or the Indenture or for any claim based on, in respect of, or by reason of, such obligations or their creation. 
 The Guarantor hereby waives diligence, presentment, demand of payment, filing of claims with a court in the event of merger or bankruptcy of the Issuer, any right to require a proceeding first against the
Issuer, the benefit of discussion, protest or notice with respect to the Notes and all demands whatsoever. 
 The Guarantor as
principal obligor and as a separate and independent obligation and liability from its other obligations and liabilities under the Indenture agrees to indemnify and keep indemnified each Holder and the Trustee in full and on demand in respect of the
performance and discharge of the Guarantee Obligations (except where the Issuer’s failure to perform or discharge the Guarantee Obligations results from such Holder’s or the Trustee’s failure to comply with its obligations under the
Indenture or the Issuer contesting any payment or part of a payment in good faith). 
 This is a continuing Guarantee and shall
remain in full force and effect and shall be binding upon the Guarantor and its successors and assigns until full and final payment of all of the Issuer’s obligations under the Notes and Indenture or until legally discharged in accordance with
the Indenture and shall inure to the benefit of the successors and assigns of the Trustee and the Holders, and, in the event of any transfer or assignment of rights by any Holder or the Trustee, the rights and privileges herein conferred upon that
party shall automatically extend to and be vested in such transferee or assignee, all subject to the terms and conditions hereof. This is a Guarantee of payment and performance and not of collectability. 

This Guarantee shall not be valid or obligatory for any purpose until the certificate of authentication on the Note upon which this
Guarantee is noted shall have been executed by the Trustee under the Indenture by the manual or facsimile signature of one of its authorized officers. 
 THE TERMS OF ARTICLE 15 OF THE INDENTURE ARE INCORPORATED HEREIN BY REFERENCE. Capitalized terms used herein have the same meanings given in the Indenture unless otherwise indicated. 

This document has been executed as a deed and is delivered and takes effect on the date stated below. 

  
 20 

 
	
	 Executed as a deed by AMARIN CORPORATION PLC
  

acting by
[                                        ]
and

	[                              
          ]
	
	                             
                                   Director
	
	                             
                                   Director
	
	Date:

  
 21 

 ASSIGNMENT FORM 
 For value received                      hereby sell(s), assign(s) and transfer(s) unto
                     (Please insert social security or Taxpayer Identification Number of assignee) the within Note, and hereby irrevocably
constitutes and appoints                      attorney to transfer the said Note on the books of the Issuer, with full power of substitution in the
premises. 
 In connection with any transfer of the within Note occurring prior to the Resale Restriction Termination Date, as defined in the
Indenture governing such Note, the undersigned confirms that such Note is being transferred: 
  

	 	 ̈	To Corsicanto Limited, Amarin Corporation plc or a subsidiary thereof; or 

  

	 	 ̈	Pursuant to a registration statement that has become or been declared effective under the Securities Act of 1933, as amended; or 

 

	 	 ̈	Pursuant to and in compliance with Rule 144A under the Securities Act of 1933, as amended; or 

 

	 	 ̈	Pursuant to and in compliance with Rule 144 under the Securities Act of 1933, as amended, or any other available exemption from the registration requirements of the
Securities Act of 1933, as amended. 

 TO BE COMPLETED BY PURCHASER IF THE THIRD BOX ABOVE IS CHECKED 

The undersigned represents and warrants that it is purchasing this Note for its own account or an account with respect to which it
exercises sole investment discretion and that it and any such account is a “qualified institutional buyer” within the meaning of Rule 144A under the Securities Act and is aware that the sale to it is being made in reliance on Rule 144A and
acknowledges that it has received such information regarding the Issuer as the undersigned has requested pursuant to Rule 144A or has determined not to request such information and that it is aware that the transferor is relying upon the
undersigned’s foregoing representations in order to claim the exemption from registration provided by Rule 144A. 
  

													
		 	  Date:	 		 	  
	 		 	Signed:	 	  

 Unless one of the above boxes is checked, the Trustee will refuse to register any of the Notes evidenced
by this certificate in the name of any Person other than the registered Holder thereof, provided that if the fourth box is checked, the Issuer or the Trustee may require, prior to registering any such transfer of the Notes, in its sole
discretion, such legal opinions, certifications and other information as the Issuer or the Trustee may reasonably request to confirm that such transfer is being made pursuant to an exemption from, or in a transaction not subject to, the registration
requirements of the Securities Act. 
 If none of the foregoing boxes is checked, the Trustee or Registrar shall not be obligated to register
this Note in the name of any Person other than the Holder hereof unless and until the conditions to any such transfer of registration set forth herein and in Section 3.11 of the Indenture shall have been satisfied. 

 

			
	Dated:	 	  

	
	  

	
	  

	Signature(s)

  
 22 

	
	  

	Signature Guarantee
	
	Signature(s) must be guaranteed by an eligible Guarantor Institution (banks, stock brokers, savings and loan associations and credit unions) with membership in an approved signature
guarantee medallion program pursuant to Securities and Exchange Commission Rule 17Ad-15 if Notes are to be delivered, other than to and in the name of the registered holder.

 NOTICE: The signature on the assignment must correspond with the name as written upon the face of the Note in every
particular without alteration or enlargement or any change whatever. 

  
 23 

 EXCHANGE NOTICE 
 If you want to exchange this Note into ADSs of the Guarantor, check the box: 
 To
exchange only part of this Note, state the principal amount to be exchanged (which must be $200,000 or an integral multiple of $1,000 in excess thereof): 
 $             
 If you
want the share certificate, if any, made out in another person’s name, fill in the form below: 
  

 
  
 (Insert other person’s social security or tax ID no.) 
  

 
  
  

 
  

 
 (Print or type other person’s
name, address and zip code) 
 Signature Guarantee:
                                         
                    
 Note: Signatures must
be guaranteed by an “eligible guarantor institution” meeting the requirements of the Registrar, which requirements include membership or participation in the Note Transfer Agent Medallion Program (“STAMP”) or such other
“signature guarantee program” as may be determined by the Registrar in addition to, or in substitution for, STAMP, all in accordance with the Exchange Act of 1934, as amended. 

  
 24 

 [Form of Fundamental Change Repurchase Notice] 

To: Wells Fargo Bank, National Association 

Corporate Trust Services 
 MAC N9311-110,

 625Marquette Ave. South 

Minneapolis, MN 55479 
 Attention: Corsicanto
Ltd. Account Manager 
 Facsimile: 612-667-9825 
 The undersigned registered owner of this Note hereby acknowledges receipt of a notice from Corsicanto Limited (the “Company”) as to the occurrence of a Fundamental Change with respect to
the Issuer and specifying the Fundamental Change Purchase Date and requests and instructs the Issuer to pay to the registered holder hereof in accordance with the applicable provisions of the Indenture referred to in this Note (1) the entire
principal amount of this Note, or the portion thereof (that is $200,000 principal amount or an integral multiple of $1,000 thereof) below designated, and (2) if such Fundamental Change Purchase Date does not fall during the period after a
Regular Record Date and on or prior to the corresponding Interest Payment Date, accrued and unpaid interest, if any, thereon to, but excluding, such Fundamental Change Purchase Date. 

In the case of Physical Notes, the certificate numbers of the Notes to be repurchased are as set forth below: 

 

									
	Dated:	 	  
	 		 		 	
		 		 		 		 	  

		 		 		 		 	Signature(s)
					
		 		 		 		 	  

		 		 		 		 	Social Security or Other Taxpayer
		 		 		 		 	Identification Number
					
		 		 		 		 	Principal amount to be repaid (if less than all): $            ,000

 NOTICE: The above signature(s) of the Holder(s) hereof must correspond with the name as written upon the
face of the Note in every particular without alteration or enlargement or any change whatever. 

  
 25 

 [Form of Optional Put Notice] 

The undersigned registered owner of this Note hereby acknowledges receipt of a notice from Corsicanto Limited (the
“Issuer”) as to the occurrence of a Repurchase Date and specifying the Repurchase Date and requests and instructs the Issuer to pay to the registered holder hereof in accordance with the applicable provisions of the Indenture
referred to in this Note (1) the entire principal amount of this Note, or the portion thereof (that is $200,000 principal amount or an integral multiple of $1,000 thereafter) below designated, and (2) if such Repurchase Date does not fall
during the period after a Regular Record Date and on or prior to the corresponding Interest Payment Date, accrued and unpaid interest, if any, thereon to, but excluding, such Repurchase Date. 

In the case of Physical Notes, the certificate numbers of the Notes to be repurchased are as set forth below: 

 

	
	Dated:
	
	  

	
	Signature(s)
	
	  

	
	Social Security or Other Taxpayer
	Identification Number
	
	Principal amount to be repaid (if less than all): $            ,000
	
	NOTICE: The above signature(s) of the Holder(s) hereof must correspond with the name as written upon the face of the Note in every particular without alteration or enlargement or
any change whatever.
	
	  

	
	Signature Guarantee
	
	Signature(s) must be guaranteed by an eligible Guarantor Institution (banks, stock brokers, savings and loan associations and credit unions) with membership in an approved signature
guarantee medallion program pursuant to Securities and Exchange Commission Rule 17Ad-15 if Notes are to be delivered, other than to and in the name of the registered holder.

  
 26 

 ARTICLE 3. 
 THE SECURITIES 
 Section 3.01 Title and Terms; Payments. 

The aggregate principal amount of Notes that may be authenticated and delivered under this Indenture is initially limited to $150,000,000
(as increased by an amount equal to the aggregate principal amount of any additional Notes purchased by the Initial Purchasers pursuant to the exercise of their option to purchase additional Notes as set forth in the Purchase Agreement) (the
“Initial Notes”), except for Notes as set forth in the Purchase Agreement authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, other Notes pursuant to Sections 3.05, 3.06, 3.07, 3.08,
3.09, 3.11, 3.12, 5.06 or 8.05. The Issuer may, from time to time after the execution of this Indenture, execute and deliver to the Trustee for authentication Additional Notes of an unlimited aggregate principal amount, and the Trustee shall
thereupon authenticate and deliver said Additional Notes to or upon the written order of the Issuer, without any further action by the Issuer hereunder; provided, however, that (1) such Additional Notes will be part of the same
issue as the Initial Notes for U.S. federal income tax purposes; (2) if any such Additional Notes are not fungible with the Initial Notes for securities laws purposes or the U.S. federal income tax purposes, any such Additional Notes will have
a separate CUSIP number so long as they remain not fungible; (3) such Additional Notes must be issued pursuant to the same terms (other than the offering price) and as the Initial Notes; and (4) the Trustee must receive an Officer’s
Certificate to the effect that such issuance of Additional Notes complies with the provisions of this Indenture, including each provision of this paragraph. 
 The Notes shall be known and designated as the “3.50% Exchangeable Senior Notes due 2032” of the Issuer. The principal amount shall be payable on the Maturity Date. 

The principal amount of Physical Notes shall be payable at the Corporate Trust Office and at any other office or agency maintained by the
Issuer for such purpose. Interest on Physical Notes will be payable (i) to Holders holding Physical Notes having an aggregate principal amount of $1,000,000 or less of Notes, by check mailed to such Holders at the address set forth in the
Register and (ii) to Holders holding Physical Notes having an aggregate principal amount of more than $1,000,000 of Notes, either by check mailed to such Holders or, upon written application by a Holder to the Registrar not later than the
relevant Regular Record Date for such interest payment, by wire transfer in immediately available funds to such Holder’s account within the United States, which application shall remain in effect until the Holder notifies the Registrar to the
contrary in writing. The Issuer will pay or cause the Paying Agent to pay principal of, and interest on, Global Notes in immediately available funds to The Depository Trust Company or its nominee, as the case may be, as the registered holder of such
global note, on each Interest Payment Date, Redemption Date, Fundamental Change Purchase Date or other payment date, as the case may be. 
 Any Notes repurchased by the Issuer will be retired and no longer outstanding hereunder. 
 Section 3.02 Ranking. The Notes constitute a general unsecured and unsubordinated obligation of the Issuer. 
 Section 3.03 Denominations. The Notes shall be issuable only in registered form without coupons and in denominations of $200,000 and any integral multiple of $1,000 in excess thereof.

 Section 3.04 Execution, Authentication, Delivery and Dating. The Notes shall be executed on behalf of the Issuer
by its Chief Executive Officer, its President, its Chief Financial Officer, any of its Vice Presidents, its Treasurer, any Assistant Treasurer, the Secretary, any of its Vice Presidents or Directors. 

Notes bearing the manual or facsimile signatures of individuals who were at any time an Officer of the Issuer shall bind the Issuer,
notwithstanding that such individual has ceased to hold such office prior to the authentication and delivery of such Notes or did not hold such office at the date of such Notes. 

  
 27 

 At any time and from time to time after the execution and delivery of this Indenture, the
Issuer may deliver Notes executed by the Issuer to the Trustee for authentication, together with a Company Order for the authentication and delivery of such Notes. The Company Order shall specify the amount of Notes to be authenticated, and shall
further specify the amount of such Notes to be issued as a Global Notes or as Physical Notes. The Trustee in accordance with such Company Order shall authenticate and deliver such Notes as in this Indenture provided and not otherwise. 

Each Note shall be dated the date of its authentication. 
 No Note shall be entitled to any benefit under this Indenture or be valid or obligatory for any purpose unless there appears on such Note a certificate of authentication substantially in the form provided
for herein executed by the Trustee by manual signature, and such certificate upon any Note shall be conclusive evidence, and the only evidence, that such Note has been duly authenticated and delivered hereunder. 

Section 3.05 Temporary Notes. Pending the preparation of Physical Notes, the Issuer may execute, and upon Company Order the
Trustee shall authenticate and deliver, temporary Notes that are printed, lithographed, typewritten, mimeographed or otherwise produced, in any authorized denomination, substantially of the tenor of the Physical Notes in lieu of which they are
issued and with such appropriate insertions, omissions, substitutions and other variations as the Officer executing such Notes may determine, as evidenced by such Officer’s execution of such Notes; provided, that any such temporary Notes
shall bear legends on the face of such Notes as set forth in Section 2.02. 
 If temporary Notes are issued, the Issuer
will cause Physical Notes to be prepared without unreasonable delay. After the preparation of Physical Notes, the temporary Notes shall be exchangeable for Physical Notes upon surrender of the temporary Notes at any office or agency of the Issuer
designated pursuant to Section 4.02, without charge to the Holder. Upon surrender for cancellation of any one or more temporary Notes, the Issuer shall execute and the Trustee shall, upon Company Order, authenticate and deliver in exchange
therefor a like principal amount of Physical Notes of authorized denominations. Until so exchanged, the temporary Notes shall in all respects be entitled to the same benefits under this Indenture as Physical Notes. 

Section 3.06 Registration; Registration of Transfer and Exchange. 

(a) The Issuer shall cause to be kept at the applicable Corporate Trust Office of the Trustee a register (the register
maintained in such office and in any other office or agency designated pursuant to Section 4.02 being herein sometimes collectively referred to as the “Register”) in which, subject to such reasonable regulations as it may
prescribe, the Issuer shall provide for the registration of Notes and of transfers of Notes. The Trustee is hereby appointed “Registrar” (the “Registrar”) for the purpose of registering Notes and transfers of Notes as
herein provided. 
 Upon surrender for registration of transfer of any Note at an office or agency of the Issuer designated
pursuant to Section 4.02 for such purpose, the Issuer shall execute, and the Trustee shall authenticate and deliver, in the name of the designated transferee or transferees, one or more new Notes of any authorized denominations and of a like
aggregate principal amount and tenor, each such Note bearing such restrictive legends as may be required by this Indenture (including Sections 2.02, 3.07 and 3.11). 
 At the option of the Holder and subject to the other provisions of Section 3.07 and to Section 3.11, Notes may be exchanged for other Notes of any authorized denominations and of a like
aggregate principal amount and tenor, upon surrender of the Notes to be exchanged at such office or agency. Whenever any Notes are so surrendered for exchange, the Issuer shall execute, and the Trustee shall, upon Company Order, authenticate and
deliver, the Notes which the Holder making the exchange is entitled to receive. 
 All Notes issued upon any registration of
transfer or exchange of Notes shall be the valid obligations of the Issuer, evidencing the same debt, and entitled to the same benefits under this Indenture, as the Notes surrendered upon such registration of transfer or exchange. 

  
 28 

 Every Note presented or surrendered for registration of transfer or for exchange shall (if
so required by the Issuer or the Trustee) be duly endorsed, or be accompanied by a written instrument of transfer in form satisfactory to the Issuer and the Registrar duly executed, by the Holder thereof or his attorney duly authorized in writing.
As a condition to the registration of transfer of any Restricted Notes, the Issuer or the Trustee may require evidence satisfactory to them as to the compliance with the restrictions set forth in the legend on such Notes. 

No service charge shall be made for any registration of transfer or exchange of Notes, but the Issuer and the Registrar may require
payment of a sum sufficient to cover any tax or other governmental charge that may be imposed in connection with any registration of transfer or exchange of Notes, other than exchanges pursuant to Section 3.05 not involving any transfer.

 Neither the Issuer nor the Registrar shall be required to exchange or register a transfer of any Note in the circumstances
set forth in Section 3.11(a)(iv). 
 (b) Neither any members of, or participants in, the Depositary
(collectively, the “Agent Members”) nor any other Persons on whose behalf any Agent Member may act shall have any rights under this Indenture with respect to any Global Note registered in the name of the Depositary or any nominee
thereof, or under any such Global Note, and the Depositary or such nominee, as the case may be, may be treated by the Issuer, the Trustee and any agent of the Issuer or the Trustee as the absolute owner and Holder of such Global Note for all
purposes whatsoever. The Trustee shall have no responsibility or obligation to any Agent Members or any other Person on whose behalf Agent Members may act with respect to (i) any ownership interests in the Global Note, (ii) the accuracy of
the records of the Depositary or its nominee, (iii) any notice required hereunder or (iv) any payments under or with respect to the Global Note. Notwithstanding the foregoing, nothing herein shall prevent the Issuer, the Trustee or any
agent of the Issuer or the Trustee from giving effect to any written certification, proxy or other authorization furnished by the Depositary or such nominee, as the case may be, or impair, as between the Depositary, its Agent Members and any other
Person on whose behalf an Agent Member may act, the operation of customary practices of such Persons governing the exercise of the rights of a Holder of any Note. The registered Holder of a Global Note may grant proxies and otherwise authorize any
Person, including Agent Members and persons that may hold interests through Agent Members, to take any action that a Holder is entitled to take under this Indenture or the Notes. 

Section 3.07 Transfer Restrictions. 

(a) Restricted Notes. 
 (i) Every Note (and all securities issued in exchange therefor or substitution thereof, except any ADSs issued upon exchange thereof) that bears, or that is required under this Section 3.07 to bear,
the Restricted Notes Legend will be deemed to be a “Restricted Note.” Each Restricted Note will be subject to the restrictions on transfer set forth in this Indenture (including in the Restricted Notes Legend) and will bear the
restricted CUSIP number for the Notes unless such restrictions on transfer are eliminated or otherwise waived by written consent of the Issuer, and each Holder of a Restricted Note, by such Holder’s acceptance of such Restricted Note, will be
deemed to be bound by the restrictions on transfer applicable to such Restricted Note. 
 (ii) Until the Resale
Restriction Termination Date, any Note (or any security issued in exchange therefor or substitution thereof, except any ADSs issued upon the exchange thereof, to which the provisions of Section 3.07(b)(ii) below shall apply) will bear the
Restricted Notes Legend unless: 
 (A) such Note, since last held by the Issuer or an affiliate of the Issuer
(within the meaning of Rule 144), if ever, was transferred (1) to a Person other than (x) the Issuer or (y) an affiliate of the Issuer (within the meaning of Rule 144) or a Person that was an affiliate of the Issuer within
the 90 days immediately preceding such transfer and (2) pursuant to a registration statement that was effective under the Securities Act at the time of such transfer; 

  
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 (B) such Note was transferred (1) to a Person other than (x) the
Issuer or (y) an affiliate of the Issuer (within the meaning of Rule 144) or a Person that was an affiliate of the Issuer within the 90 days immediately preceding such transfer and (2) pursuant to the exemption from registration
provided by Rule 144 or any similar provision then in force under the Securities Act; or 
 (C) the Issuer
delivers written notice to the Trustee and the Registrar stating that the Restricted Notes Legend may be removed from such Note and all Applicable Procedures of have been complied with. 

(iii) In addition, until the Resale Restriction Termination Date: 

(A) no transfer of any Note will be registered by the Registrar prior to the Resale Restriction Termination Date unless
the transferring Holder delivers the form of assignment set forth on the Note, with the appropriate box checked, to the Trustee; and 
 (B) the Registrar will not register any transfer of any Note that is a Restricted Note to a Person that is an affiliate of the Issuer or has been an affiliate of the Issuer (within the meaning of
Rule 144) within the 90 days immediately preceding the date of such proposed transfer. 
 (iv) On and after
the Resale Restriction Termination Date, any Note (or any security issued in exchange therefor or substitution thereof, except any ADSs issued upon the exchange thereof) will bear the Restricted Notes Legend at any time the Issuer reasonably
determinates that, to comply with law, such Note (or such securities issued in exchange for or substitution of a Note) must bear the Restricted Notes Legend. 
 (b) Restricted Stock. 
 (i) Every ADS that bears, or that
is required under this Section 3.07 to bear, the Restricted Stock Legend will be deemed to be “Restricted Stock.” Each share of Restricted Stock will be subject to the restrictions on transfer set forth in this Indenture
(including in the Restricted Stock Legend) and will bear a restricted CUSIP number unless such restrictions on transfer are eliminated or otherwise waived by written consent of the Issuer, and each Holder of Restricted Stock, by such Holder’s
acceptance of Restricted Stock, will be deemed to be bound by the restrictions on transfer applicable to such Restricted Stock. 
 (ii) Until the Resale Restriction Termination Date, any ADSs issued upon the exchange of a Note, and any ADSs issued upon an exchange of a Restricted Note, will be issued in book-entry form and will bear
the Restricted Stock Legend unless the Issuer delivers written notice to the Trustee, the Registrar and ADS Depositary (and/or other transfer agent for the ADSs) stating that such ADSs need not bear the Restricted Stock Legend. 

(iii) On and after the Resale Restriction Termination Date, ADSs will be issued in book-entry form and will bear the
Restricted Stock Legend at any time the Issuer reasonably determinates that, to comply with law, such ADSs must bear the Restricted Stock Legend. 
 (c) As used in this Section 3.07, the term “transfer” means any sale, pledge, transfer, loan, hypothecation or other disposition whatsoever of any Restricted Note, any interest
therein or any Restricted Stock. 

  
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 Section 3.08 Expiration of Restrictions. 

(a) Physical Notes. Any Physical Note (or any security issued in exchange or substitution therefor) that does not
constitute a Restricted Note may be exchanged for a new Note or Notes of like tenor and aggregate principal amount that do not bear the Restricted Notes Legend required by Section 3.07. To exercise such right of exchange, the Holder of such
Note must surrender such Note in accordance with the provisions of Section 3.11 and deliver any additional documentation reasonably required by the Issuer, the Trustee or the Registrar in connection with such exchange. 

(b) Global Notes; Resale Restriction Termination Date. 

(i) If, on the Free Trade Date, or the next succeeding Business Day if the Free Trade Date is not a Business Day, any
Notes are represented by a Global Note that is a Restricted Note (any such Global Note, a “Restricted Global Note”), as promptly as practicable, the Issuer will automatically exchange every beneficial interest in each Restricted
Global Note for beneficial interests in Global Notes that are not subject to the restrictions set forth in the Restricted Notes Legend and in Section 3.07 hereof. 

(ii) To effect such automatic exchange, the Issuer will (A) deliver to the Depositary an instruction letter for the
Depositary’s mandatory exchange process at least 15 days immediately prior to the Free Trade Date and (B) deliver to each of the Trustee and the Registrar a duly completed Free Transferability Certificate promptly after the Free Trade Date
and an Opinion of Counsel. Such Opinion of Counsel will be to the effect that the Restrictive Notes Legend may be removed from all certificates evidencing Restricted Global Notes and all outstanding Notes represented thereby are Freely Tradable
(provided that such opinion may assume compliance by the Noteholders with the restrictions set forth in the legends on the Notes). The first date on which both the Trustee and the Registrar have received the Free Transferability Certificate and such
Opinion of Counsel will be known as the “Resale Restriction Termination Date.” 
 (iii)
Immediately upon receipt of the Free Transferability Certificate by each of the Trustee and the Registrar the Restricted Notes Legend will be deemed removed from each of the Global Notes specified in such Free Transferability Certificate and the
restricted CUSIP number will be deemed removed from each of such Global Notes and deemed replaced with an unrestricted CUSIP number. 
 (iv) Promptly after the Resale Restriction Termination Date, the Issuer will provide Bloomberg LLP with a copy of the Free Transferability Certificate and will use reasonable efforts to cause Bloomberg
LLP to adjust its screen page for the Notes to indicate that the Notes are no longer Restricted Notes and are now identified by an unrestricted CUSIP number. 
 (v) Prior to the Issuer’s delivery of the Free Transferability Certificate and afterwards, the Issuer and the Trustee will comply with the Applicable Procedures and otherwise use reasonable efforts
to cause each Global Note to be identified by an unrestricted CUSIP number in the facilities of the Depositary by the date the Free Transferability Certificate is delivered to the Trustee and the Registrar or as promptly as possible thereafter.

 (vi) Notwithstanding anything to the contrary in Sections 3.08(b)(i), (ii) or (iii), the Issuer
will not be required to deliver the Free Transferability Certificate if it reasonably believes that removal of the Restricted Notes Legend or the changes to the CUSIP numbers for the Notes could result in or facilitate transfers of the Notes in
violation of applicable law. 
 Section 3.09 Mutilated, Destroyed, Lost and Stolen Notes. If any mutilated Note is
surrendered to the Trustee, the Issuer shall execute and the Trustee shall authenticate and deliver in exchange therefor a new Note of like tenor and principal amount and bearing a number not contemporaneously outstanding. 

  
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 If there shall be delivered to the Issuer and the Trustee (i) evidence to their
satisfaction of the destruction, loss or theft of any Note and (ii) such security or indemnity as may be required by them to save each of them and any agent of either of them harmless, then, in the absence of notice to the Issuer or the Trustee
that such Note has been acquired by a bona fide purchaser, the Issuer shall execute and the Trustee shall authenticate and deliver, in lieu of any such destroyed, lost or stolen Note, a new Note of like tenor and principal amount and bearing a
number not contemporaneously outstanding. 
 In case any such mutilated, destroyed, lost or stolen Note has become or is about
to become due and payable, the Issuer in its discretion may, instead of issuing a new Note, pay such Note. 
 Upon the issuance
of any new Note under this Section 3.09, the Issuer may require payment by the Holder of a sum sufficient to cover any tax or other governmental charge that may be imposed in relation thereto and any other expenses (including the fees and
expenses of the Trustee) connected therewith. 
 Every new Note issued pursuant to this Section 3.09 in lieu of any
destroyed, lost or stolen Note shall constitute an original additional contractual obligation of the Issuer, whether or not the destroyed, lost or stolen Note shall be at any time enforceable by anyone, and shall be entitled to all the benefits of
this Indenture equally and proportionately with any and all other Notes duly issued hereunder. 
 The provisions of this Section
are exclusive and shall preclude (to the extent lawful) all other rights and remedies with respect to the replacement or payment of mutilated, destroyed, lost or stolen Notes. 

Section 3.10 Persons Deemed Owners. Prior to due presentment of a Note for registration of transfer, the Issuer, the
Guarantor, the Trustee, the Registrar and any agent of the Issuer, the Guarantor, the Trustee or the Registrar may treat the Person in whose name such Note is registered in the Register as the owner of such Note for the purpose of receiving payment
of the principal of such Note and for all other purposes whatsoever, whether or not such Note be overdue, and neither the Issuer, the Guarantor, the Trustee, the Registrar nor any agent of the Issuer, the Guarantor, the Trustee or the Registrar
shall be affected by notice to the contrary. 
 Section 3.11 Transfer and Exchange. 

(a) Provisions Applicable to All Transfers and Exchanges.  

(i) Subject to the restrictions set forth in this Section 3.11, Physical Notes and beneficial interests in Global
Notes may be transferred or exchanged from time to time as desired, and each such transfer or exchange will be noted by the Registrar in the Register. 
 (ii) All Notes issued upon any registration of transfer or exchange in accordance with this Indenture will be the valid obligations of the Issuer, evidencing the same debt, and entitled to the same
benefits under this Indenture as the Notes surrendered upon such registration of transfer or exchange. 
 (iii)
No service charge will be imposed on any Holder of a Physical Note or any owner of a beneficial interest in a Global Note for any exchange or registration of transfer, but each of the Issuer, the Trustee or the Registrar may require such Holder or
owner of a beneficial interest to pay a sum sufficient to cover any transfer tax, assessment or other governmental charge imposed in connection with such registration of transfer or exchange. 

(iv) Unless the Issuer specifies otherwise, none of the Issuer, the Trustee, the Registrar or any co-Registrar will be
required to exchange or register a transfer of any Note (i) that has been surrendered for exchange, (ii) as to which Section 5.06 is applicable or (iii) as to which a Fundamental Change Purchase Notice or an Optional Put Notice
has been delivered and not withdrawn, in each case, except to the extent any portion of such Note is not subject to the foregoing. 

  
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 (v) The Trustee will have no obligation or duty to monitor, determine or
inquire as to compliance with any restrictions on transfer imposed under this Indenture or under applicable law with respect to any transfer of any interest in any Note (including any transfers between or among Depositary participants or beneficial
owners of interests in any Global Note) other than to require delivery of such certificates and other documentation or evidence as are expressly required by, and to do so if and when expressly required by the terms of, this Indenture, and to examine
the same to determine substantial compliance as to form with the express requirements hereof. 
 (b) In
General; Transfer and Exchange of Beneficial Interests in Global Notes. So long as the Notes are eligible for book-entry settlement with the Depositary, unless otherwise required by law, except to the extent required by Section 3.11(c):

 (i) all Notes will be represented by one or more Global Notes; 

(ii) every transfer and exchange of a beneficial interest in a Global Note will be effected through the Depositary in
accordance with the Applicable Procedures and the provisions of this Indenture (including the restrictions on transfer set forth in Section 3.07); and 
 (iii) each Global Note may be transferred only as a whole and only (A) by the Depositary to a nominee of the Depositary, (B) by a nominee of the Depositary to the Depositary or to another
nominee of the Depositary, or (C) by the Depositary or any such nominee to a successor Depositary or a nominee of such successor Depositary. 
 (c) Transfer and Exchange of Global Notes. 
 (i)
Notwithstanding any other provision of this Indenture, each Global Note will be exchanged for Physical Notes if the Depositary delivers notice to the Issuer that: 

(A) the Depositary is unwilling or unable to continue to act as Depositary; or 

(B) the Depositary is no longer registered as a clearing agency under the Exchange Act; 

and, in each case, the Issuer promptly delivers a copy of such notice to the Trustee and the Issuer fails to appoint a successor
Depositary within 90 days after receiving notice from the Depositary. 
 In each such case, each Global Note
will be deemed surrendered to the Trustee for cancellation, and the Trustee will cause each Global Note to be cancelled in accordance with the Applicable Procedures, and the Issuer, in accordance with Section 3.04, will promptly execute, and,
upon receipt of a Company Order, the Trustee will, in accordance with Section 3.04, will promptly authenticate and deliver, for each beneficial interest in each Global Note so exchanged, an aggregate principal amount of Physical Notes equal to
the aggregate principal amount of such beneficial interest, registered in such names and in such authorized denominations as the Depositary specifies, and bearing any legends that such Physical Notes are required to bear under Section 3.07.

 (ii) In addition, if (x) the Issuer, in its sole discretion, determines that any Global Note will be
exchangeable for Physical Notes or (y) an Event of Default has occurred and is continuing, in each case, any owner of a beneficial interest in a Global Note may exchange such beneficial interest for Physical Notes by delivering a written
request to the Registrar. 
 In such case, (A) the Registrar will deliver notice of such request to the
Issuer and the Trustee, which notice will identify the aggregate principal amount of such beneficial interest and 

  
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the CUSIP of the relevant Global Note; (B) the Issuer will, in accordance with Section 3.04, promptly execute, and, upon receipt of a Company Order, the Trustee, in accordance with
Section 3.04, will promptly authenticate and deliver, to such owner, for the beneficial interest so exchanged by such owner, Physical Notes registered in such owner’s name having an aggregate principal amount equal to the aggregate
principal amount of such beneficial interest and bearing any legends that such Physical Notes are required to bear under Section 3.07, and (C) the Registrar, in accordance with the Applicable Procedures, will cause the principal amount of
such Global Note to be decreased by the aggregate principal amount of the beneficial interest so exchanged. If all of the beneficial interests in a Global Note are so exchanged, such Global Note will be deemed surrendered to the Trustee for
cancellation, and the Trustee will cause such Global Note to be cancelled in accordance with the Applicable Procedures. 
 (d) Transfer and Exchange of Physical Notes. 
 (i) If
Physical Notes are issued, a Holder may transfer a Physical Note by: (A) surrendering such Physical Note for registration of transfer to the Registrar, together with any endorsements or instruments of transfer required by any of the Issuer, the
Trustee or the Registrar; (B) if such Physical Note is a Restricted Note, delivering any documentation that the Issuer, the Trustee or the Registrar reasonably require to ensure that such transfer complies with Section 3.07 and any
applicable securities laws; and (C) satisfying all other requirements for such transfer set forth in this Section 3.11 and Section 3.07. Upon the satisfaction of conditions (A), (B) and (C), the Issuer, in accordance with
Section 3.04, will promptly execute and deliver to the Trustee, and the Trustee, upon receipt of a Company Order, will, in accordance with Section 3.04, promptly authenticate and deliver, in the name of the designated transferee or
transferees, one or more new Physical Notes, of any authorized denominations, having like aggregate principal amount and bearing any restrictive legends required by Section 3.07. 

(ii) If Physical Notes are issued, a Holder may exchange a Physical Note for other Physical Notes of any authorized
denominations and aggregate principal amount equal to the aggregate principal amount of the Notes to be exchanged by surrendering such Notes, together with any endorsements or instruments of transfer required by any of the Issuer, the Trustee or the
Registrar, at any office or agency maintained by the Issuer for such purposes pursuant to Section 4.02. Whenever a Holder surrenders Notes for exchange, the Issuer, in accordance with Section 3.04, will promptly execute and deliver to the
Trustee, and the Trustee, upon receipt of a Company Order, will, in accordance with Section 3.04, promptly authenticate and deliver the Notes that such Holder is entitled to receive, bearing registration numbers not contemporaneously
outstanding and any restrictive legends that such Physical Notes are to bear under Section 3.07. 
 (iii)
If Physical Notes are issued, a Holder may transfer or exchange a Physical Note for a beneficial interest in a Global Note by (A) surrendering such Physical Note for registration of transfer or exchange, together with any endorsements or
instruments of transfer required by any of the Issuer, the Trustee or the Registrar, at any office or agency maintained by the Issuer for such purposes pursuant to Section 4.02; (B) if such Physical Note is a Restricted Note, delivering
any documentation the Issuer, the Trustee or the Registrar reasonably require to ensure that such transfer complies with Section 3.07 and any applicable securities laws; (C) satisfying all other requirements for such transfer set forth in
this Section 3.11 and Section 3.07; and (D) providing written instructions to the Trustee to make, or to direct the Registrar to make, an adjustment in its books and records with respect to the applicable Global Note to reflect an
increase in the aggregate principal amount of the Notes represented by such Global Note, which instructions will contain information regarding the Depositary account to be credited with such increase. Upon the satisfaction of conditions (A), (B),
(C) and (D), the Trustee will cancel such Physical Note and cause, or direct the Registrar to cause, in accordance with the Applicable Procedures, the aggregate principal amount of Notes represented by such Global Note to be increased by the
aggregate principal amount of such Physical Note, and will credit or cause to be credited the account of the Person specified in the instructions provided by the exchanging Holder in an amount equal to the aggregate principal amount of such Physical
Note. If no Global Notes are 

  
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then outstanding, the Issuer, in accordance with Section 3.04, will promptly execute and deliver to the Trustee, and the Trustee, upon receipt of a Company Order, will, in accordance with
Section 3.04, authenticate, a new Global Note in the appropriate aggregate principal amount. 
 Section 3.12
Cancellation. The Issuer at any time may deliver to the Trustee for cancellation any Notes previously authenticated and delivered hereunder that the Issuer may have acquired in any manner whatsoever, and may deliver to the Trustee for
cancellation any Notes previously authenticated hereunder which the Issuer has not issued and sold. The Trustee shall cancel all Notes surrendered for registration of transfer, exchange, payment, purchase, repurchase, exchange (pursuant to Article 7
hereof) or cancellation in accordance with its customary practices. If the Issuer or the Guarantor shall acquire any of the Notes, such acquisition shall not operate as a redemption or satisfaction of the indebtedness represented by such Notes
unless and until the same are delivered to the Trustee for cancellation. The Notes so acquired, while held by or on behalf of the Issuer or the Guarantor or any of its Subsidiaries, shall not entitle the Holder thereof to exchange the Notes. The
Issuer may not issue new Notes to replace Notes it has paid in full or delivered to the Trustee for cancellation. The Issuer and the Guarantor may from time to time repurchase Notes in open market purchases or negotiated transactions without
giving prior notice to Holders. Any Notes repurchased by the Issuer or the Guarantor will be immediately cancelled and no longer outstanding under this Indenture. 
 The Registrar shall retain, in accordance with its customary procedures, copies of all letters, notices and other written communications received pursuant to this Section 3.12. The Issuer shall have
the right to inspect and make copies of all such letters, notices or other written communications at any reasonable time upon the giving of reasonable written notice to the Registrar. 

Section 3.13 CUSIP Numbers. In issuing the Notes, the Issuer may use “CUSIP” numbers (if then generally in use),
and, if so, the Trustee shall use “CUSIP” numbers in notices of redemption as a convenience to Holders; provided that the Trustee shall have no liability for any defect in the CUSIP numbers as they appear on any Notes, notice, or
elsewhere and; provided further, that any such notice may state that no representation is made as to the correctness of such numbers either as printed on the Notes or as contained in any notice of a redemption and that reliance may be placed
only on the other identification numbers printed on the Notes, and any such redemption shall not be affected by any defect in or omission of such numbers. The Issuer will promptly notify the Trustee in writing of any change in the “CUSIP”
numbers. 
 Section 3.14 Payment and Computation of Interest. The Notes will bear cash interest at a rate of
3.50% per year until maturity. Interest on the Notes will accrue from the most recent date on which interest has been paid or duly provided for or, if no interest has been paid or duly provided for, January 9, 2012. Interest will be paid
semiannually in arrears on January 15 and July 15 of each year, beginning July 15, 2012. Interest on the Notes shall be computed on the basis of a 360-day year consisting of twelve 30-day months. 

Section 3.15 Business Day. If any Interest Payment Date, the Maturity Date, any Fundamental Change Repurchase Date,
Repurchase Date or Redemption Date falls on a day that is not a Business Day, the required payment will be made on the next succeeding Business Day and no interest on such payment will accrue in respect of the delay. 

ARTICLE 4. 

PARTICULAR COVENANTS OF THE ISSUER 
 Section 4.01 Payment of Principal and Interest. The Issuer will pay or cause to be paid the principal of, Fundamental Change Repurchase Price for, Repurchase Price for, Redemption Price for
and any Additional Amounts with respect to, or the Exchange Obligation with respect to, and any accrued and unpaid interest (including Additional Interest, if any) on, the Notes on the dates and in the manner required under this Indenture and the
Notes. Any principal of, Fundamental Change Repurchase Price for, Repurchase Price for, Redemption Price for, Additional Amounts with respect to, Exchange Obligation with respect to, or interest (including Additional Interest, if any) on, a Note
will be considered paid on the date due if the Paying Agent, if other than the Issuer, holds, as of 10:00 a.m., New York City time, on the due date, money deposited by the Issuer in immediately available funds and

  
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designated for and sufficient to pay such principal, Fundamental Change Repurchase Price, Repurchase Price, Redemption Price Additional Amount, Exchange Obligation or interest (including
Additional Interest, if any) then due. Payments of the Fundamental Change Repurchase Price, Repurchase Price, Redemption Price, principal or interest that are not made when due will accrue interest per annum at the then-applicable interest rate from
the requirement payment date. 
 Section 4.02 Maintenance of Office or Agency. 

(a) The Issuer shall maintain in the U.S. at least one office or agency where Notes may be presented for exchange
(“Exchange Agent”) and at least one office of the Paying Agent. In addition, the Issuer will maintain a Paying Agent and Registrar in a jurisdiction that is not obligated to withhold or deduct tax pursuant to the European Union
Directive 2003/48/EC or any other directive implementing the conclusions of the ECOFIN Council meeting of 26 and 27 November 2000 on the taxation of savings income, or any law implementing, or complying with or introduced in order to conform
to, such directive. 
 The Issuer may have one or more registrars, one or more additional paying agents and one or more additional exchange
agents. The term Paying Agent includes any additional paying agents. The term Exchange Agent includes any additional exchange agents. The term Registrar includes any additional registrars. 

(b) The Issuer shall enter into an appropriate agency agreement with any Registrar, Paying Agent or Exchange Agent (other
than the Trustee). The agreement shall implement the provisions of this Indenture that relate to such agent. The Issuer shall notify the Trustee in writing of the name and address of any such agent. If the Issuer fails to maintain a Registrar,
Paying Agent or Exchange Agent, the Trustee shall act as such and shall be entitled to appropriate compensation therefor pursuant to Section 11.07. The Issuer or its Affiliate may act as Paying Agent, Registrar, Exchange Agent or co-registrar.

 (c) The Issuer initially appoints the Trustee as Registrar, Exchange Agent and Paying Agent in connection
with the Notes. At any time, the Issuer may change such designation by delivering written notice to the Trustee signed by any officer authorized to sign an Officer’s Certificate and delivered to the Trustee, which notice will designate some
other office or agency as the Registrar, Exchange Agent or Paying Agent, as the case may be. If at any time the Issuer shall fail to maintain such office or agency or shall fail to furnish the Trustee with the address thereof, Notes may be
surrendered for exchange at the Corporate Trust Office of Trustee. 
 So long as the Trustee is the Registrar, the Trustee
agrees to mail, or cause to be mailed, in accordance with and subject to Section 1.06 the notices set forth in Section 11.11(a) and the third paragraph of Section 11.12. If co-Registrars have been appointed in accordance with this
Section, the Trustee shall mail such notices only to the Issuer and the Holders of Notes it can identify from its records. 

Section 4.03 Appointments to Fill Vacancies in Trustee’s Office. The Issuer, whenever necessary to avoid or fill a
vacancy in the office of Trustee, will appoint, in the manner provided in Section 11.11, a Trustee, so that there shall at all times be a Trustee hereunder. 
 Section 4.04 Provisions as to Paying Agent. 
 (a) The
Issuer may designate additional Paying Agents, rescind the designation of any Paying Agent, or approve a change in the office through which any Paying Agent acts. If the Issuer shall appoint a Paying Agent other than the Trustee, or if the Trustee
shall appoint such a Paying Agent, the Issuer will cause such Paying Agent to execute and deliver to the Trustee an instrument in which such agent shall agree with the Trustee, subject to the provisions of this Section 4.04: 

(i) that it will hold all sums held by it as such agent for the payment of the principal of or interest on the Notes
(whether such sums have been paid to it by the Issuer or by any other obligor on the Notes) in trust for the benefit of the Holders of the Notes; 

  
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 (ii) that it will give the Trustee notice of any failure by the Issuer (or
by any other obligor on the Notes) to make any payment of the principal of or interest on the Notes when the same shall be due and payable; and 
 (iii) that at any time during the continuance of an Event of Default, upon request of the Trustee, it will forthwith pay to the Trustee all sums so held in trust. 

(b) The Issuer shall, on or before each due date of the principal of or interest on the Notes, deposit with the Paying
Agent a sum (in funds which are immediately available on the due date for such payment) sufficient to pay such principal or interest, and (unless such Paying Agent is the Trustee) the Issuer will promptly notify the Trustee of any failure to take
such action; provided, however, that if such deposit is made on the due date, such deposit shall be received by the Paying Agent by 10:00 a.m. New York City time, on such date. 

(c) If the Issuer shall act as its own Paying Agent, it will, on or before each due date of the principal of or interest
on the Notes, set aside, segregate and hold in trust for the benefit of the Holders of the Notes a sum sufficient to pay such principal or interest so becoming due and will promptly notify the Trustee of any failure to take such action and of any
failure by the Issuer (or any other obligor under the Notes) to make any payment of the principal of or interest on the Notes when the same shall become due and payable. 

(d) Anything in this Section 4.04 to the contrary notwithstanding, the Issuer may, at any time, for the purpose of
obtaining a satisfaction and discharge of this Indenture, or for any other reason, pay or cause to be paid to the Trustee all sums held in trust by the Issuer or any Paying Agent hereunder as required by this Section 4.04, such sums to be held
by the Trustee upon the trusts herein contained and upon such payment by the Issuer or any Paying Agent to the Trustee, the Issuer or such Paying Agent shall be released from all further liability with respect to such sums. 

(e) Anything in this Section 4.04 to the contrary notwithstanding, the agreement to hold sums in trust as provided
in this Section 4.04 is subject to Section 13.03 and Section 13.04. 
 The Trustee shall not be responsible for
the actions of any other Paying Agents (including the Issuer if acting as its own Paying Agent) and shall have no control of any funds held by such other Paying Agents. 
 Section 4.05 Existence. Subject to Article 10, each of the Issuer and the Guarantor will do or cause to be done all things necessary to preserve and keep in full force and effect its existence
and rights (charter and statutory); provided, however, that the Issuer and the Guarantor shall not be required to preserve any such right if the Issuer or the Guarantor, as applicable, shall determine that the preservation thereof is
no longer desirable in the conduct of the business of the Issuer or the Guarantor, as applicable. 
 Section 4.06 No
Other Indebtedness. The Issuer will not, directly or indirectly, create, incur, assume or guaranty, or otherwise become or remain directly or indirectly liable with respect to any indebtedness or any other obligations or liabilities, in
each case, other than its obligations under the Notes and other than pursuant to intercompany transactions and in connection with refinancing the Notes. 
 Section 4.07 Additional Interest. 
 (a) If, at any
time during the six-month period beginning on, and including, the date which is six months after the last date of original issuance of any of the Initial Notes, the Guarantor fails to have timely filed any document or report that the Guarantor is
required to file with the Commission pursuant to Section 13 or 15(d) of the Exchange Act, as applicable (after giving effect to all applicable grace periods thereunder and other than current reports on Form 8-K), or the Notes are not otherwise
Freely Tradable (as a result of restrictions pursuant to U.S. securities law or the terms of this Indenture or the Notes), the Issuer shall pay Additional Interest on the Notes which shall accrue at the rate of 0.50% per annum of the principal
amount of Notes outstanding for each day during such period for which the Guarantor’s failure to file has occurred and is continuing or for which the Notes are not Freely Tradable (ending on the date that is one year from the last date of
original issuance of any of the Initial Notes). 

  
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 (b) Further, if, and for so long as, the Restrictive Notes Legend has not
been removed from the Notes, the Notes are assigned a restricted CUSIP number or the Notes are not otherwise Freely Tradable as of the 376th day after the last date of original issuance of any of the Initial Notes, the Issuer shall pay Additional
Interest on the Notes. Such Additional Interest will accrue on the Notes at the rate of 0.50% per annum of the principal amount of Notes outstanding from the 376th day after the last date of original issuance of any of the Initial Notes until
the Restrictive Notes Legend has been removed in accordance with Section 3.08, the Notes are assigned an unrestricted CUSIP number and the Notes are Freely Tradable. 

(c) The obligations of the Issuer pursuant to this Section 4.07 are separate and distinct from, and in addition to,
the obligations of the Issuer pursuant to Section 9.04. Any Additional Interest payable pursuant to this Section 4.07 will be payable in arrears on each Interest Payment Date following accrual in the same manner as ordinary interest is
payable. 
 (d) The Issuer shall notify the Holders, the Trustee and the Paying Agent in writing of any
Additional Interest that has become due and payable within three Business Days after each and every event which has caused Additional Interest to become due. Such notice shall include reference to the event that caused the Additional Interest to
become due, the Additional Interest rate and the date from which such Additional Interest shall begin to accrue. Within three Business Days after such Additional Interest shall cease to accrue, the Issuer shall notify the Holders, the Trustee and
the Paying Agent in writing. Such notice shall explain why the Additional Interest shall no longer be due and specify the last date to which such Additional Interest will accrue. 

Section 4.08 Rule 144A. The Guarantor will also comply with the other provisions of Section 314(a) of the Trust
Indenture Act. Any document filed by the Guarantor with the Commission via the EDGAR system (or any successor thereto) will be deemed to be delivered to the Trustee at the time such document is filed via the EDGAR system (or such successor thereto);
provided, however, that the Trustee shall have no obligation whatsoever to determine if such filing has occurred. 

Delivery of such quarterly and annual reports, and such other documents, information and reports to the Trustee will be for informational
purposes only, and the Trustee’s receipt of such will not constitute constructive notice of any information contained therein or determinable from information contained therein, including the Issuer’s or the Guarantor’s compliance
with any of its covenants hereunder (as to which the Trustee is entitled to rely conclusively on Officer’s Certificates). 

The Issuer and the Guarantor will take such further action as any Holder or beneficial owner of such Notes or such ADSs, as applicable,
may reasonably request from time to time to enable such Holder or beneficial owner to sell Restricted Notes or Restricted Stock, as applicable, in accordance with Rule 144A under the Securities Act, as such rule may be amended from time to time.

 Section 4.09 Resale of Certain Notes. The Issuer and the Guarantor shall not, and shall not permit any of the
Guarantor’s Subsidiaries to, resell any Notes that have been reacquired by the Issuer, the Guarantor or any such Subsidiary. The Trustee shall have no responsibility in respect of the Issuer’s performance of its agreement in the preceding
sentence. 
 Section 4.10 Commission Filings and Reports. The Issuer covenants that any documents or reports that
the Guarantor is required to file with the Commission pursuant to Section 13 or 15(d) of the Exchange Act shall be filed by the Issuer with the Trustee within 15 calendar days after the same is filed with the Commission pursuant to its rules
and regulations (giving effect to any grace period provided by Rule 12b-25 under the Exchange Act); provided that in each case the delivery of materials to the Trustee by electronic means or filing of documents pursuant to the
Commission’s “EDGAR” system (or any successor electronic filing system) shall be deemed to constitute “filing” with the Trustee for purposes of this Section 4.10; provided, however, that the Trustee shall have no
obligation whatsoever to determine if such filing has occurred. Delivery of such reports, information and 

  
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documents to the Trustee is for informational purposes only and the Trustee’s receipt of such shall not constitute constructive notice of any information contained therein or determinable
from information contained therein, including the Issuer’s compliance with any of its covenants hereunder (as to which the Trustee is entitled to rely exclusively on Officer’s Certificates). 

Section 4.11 Book-Entry System. If the Notes cease to trade in the Depositary’s book-entry settlement system, the
Issuer covenants and agrees that it shall use reasonable efforts to make such other book-entry arrangements that it determines are reasonable for the Notes. 
 Section 4.12 Par Value Limitation. The Issuer will not take any action that, after giving effect to any adjustment pursuant to Section 7.05 or Section 7.06 hereof, would result in
the Exchange Price becoming less than (i) the par value of one ADS and/or (ii) the par value of one Ordinary Share multiplied by the number of Ordinary Shares then represented by one ADS. 

Section 4.13 [Reserved.] 
 Section 4.14 Stay; Extension and Usury Laws. The Issuer covenants (to the extent that it may lawfully do so) that it shall not at any time insist upon, plead, or in any manner whatsoever claim
or take the benefit or advantage of, any stay, extension or usury law or other law which would prohibit or forgive the Issuer from paying all or any portion of the principal of or interest on the Notes as contemplated herein, wherever enacted, now
or at any time hereafter in force, or which may affect the covenants or the performance of this Indenture and the Issuer (to the extent it may lawfully do so) hereby expressly waives all benefit or advantage of any such law, and covenants that it
will not, by resort to any such law, hinder, delay or impede the execution of any power herein granted to the Trustee, but will suffer and permit the execution of every such power as though no such law had been enacted. 

Section 4.15 Compliance Certificate. The Issuer shall deliver to the Trustee, within one hundred twenty (120) days
after the end of each fiscal year of the Issuer (commencing with the fiscal year ending 2012), an Officer’s Certificate, stating whether or not to the knowledge of the signer thereof the Issuer is in default in the performance and observance of
any of the terms, provisions and conditions of this Indenture (without regard to any period of grace or requirement of notice provided hereunder) and, if the Issuer shall be in default, specifying all such defaults and the nature and the status
thereof of which the signer may have knowledge. 
 The Issuer shall deliver to the Trustee, within 15 Business Days after the
Issuer becomes aware of the occurrence of any Event of Default or an event which, with notice or the lapse of time or both, would constitute an Event of Default, an Officer’s Certificate setting forth the details of such Event of Default or
Default, its status and the action which the Issuer proposes to take with respect thereto. 
 Any notice required to be given
under this Section 4.15 shall be delivered to a Trust Officer of the Trustee at its Corporate Trust Office. 

Section 4.16 Additional Amounts. All payments and deliveries made by or on behalf of the Issuer or the Guarantor, or
any successor to the Issuer or the Guarantor under or with respect to any Note, including, but not limited to, payments of principal (including the Fundamental Change Repurchase Price, Repurchase Price and Redemption Price, if applicable), premium,
if any, payments of interest, including any Additional Interest, and payments of cash and/or deliveries of ADSs (together with payments of cash for any fractional ADS) upon exchange and any payments under the Guarantee pursuant to Article 15, shall
be made without withholding or deduction for, or on account of, any present or future taxes, duties, assessments or governmental charges of whatever nature imposed or levied (including any penalties and interest related thereto) (“Applicable
Taxes”) by or within (1) the U.K. or Ireland (meaning Ireland exclusive of Northern Ireland) (or, in each case, any political subdivision or taxing authority thereof or therein), (2) any jurisdiction in which the Issuer or the
Guarantor or any of their successors are, for tax purposes, incorporated, organized or resident or doing business (or any political subdivision or taxing authority thereof or therein) or (3) any jurisdiction through which payment is made (or
any political subdivision or taxing authority thereof or therein) (each of (1), (2) and (3), as applicable, a “Relevant Taxing Jurisdiction”), unless such withholding or deduction is required by law. In the event that any such
withholding or deduction is so required, the Issuer or the Guarantor, as appropriate, shall pay to the Holder of each Note such additional amounts (the “Additional Amounts”) as may be necessary to ensure that the net amount received by the
beneficial owner 

  
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after such withholding or deduction (and after deducting any Applicable Taxes on the Additional Amounts) will equal the amounts that would have been received by such beneficial owner had no such
withholding or deduction been required; provided that no additional amounts will be payable: 
 (i) for or on
account of: 
 (A) any Applicable Taxes that would not have been imposed but for: 

(1) other than in respect of Irish dividend withholding tax, the existence of any present or former connection between
the relevant Holder or beneficial owner of such Note and the Relevant Taxing Jurisdiction, other than merely acquiring or holding such Note or the receipt of payments or the exercise or enforcement of rights thereunder, including, without
limitation, such Holder or beneficial owner being or having been a national, domiciliary or resident of such Relevant Taxing Jurisdiction or treated as a resident thereof or being or having been physically present or engaged in a trade or business
therein or having or having had a permanent establishment therein; 
 (2) the presentation of such Note (in
cases in which presentation is required) more than 30 days after the later of the date on which the payment of the principal of (including the Fundamental Change Repurchase Price, Repurchase Price and Redemption Price, if applicable), premium, if
any, and interest on, such Note became due and payable pursuant to the terms thereof or was made or duly provided for (except to the extent that the Holder or beneficial owner would have been entitled to Additional Amounts had the Note been
presented on the last day of such 30 day period); or 
 (3) other than in respect of Irish dividend withholding
tax, the failure of the Holder or beneficial owner to comply with a timely and reasonable written request from the Issuer or any successor to the Issuer, addressed to the Holder or beneficial owner, as the case may be, in each case, to the extent
such Holder or beneficial owner is legally entitled to, to provide certification, information, documents or other evidence concerning such Holder’s or beneficial owner’s nationality, residence, identity or connection with the Relevant
Taxing Jurisdiction, or to make any declaration or satisfy any other reporting requirement relating to such matters, if and to the extent that due and timely compliance with such request is required by statute, regulation or administrative practice
of the Relevant Taxing Jurisdiction to reduce or eliminate any withholding or deduction as to which Additional Amounts would have otherwise been payable to such Holder or beneficial owner; 

(B) any estate, inheritance, gift, sale, personal property or similar Applicable Taxes; 

(C) any Applicable Taxes that are payable otherwise than by withholding or deduction from payments under or with respect
to the Notes; or 
 (D) any combination of Applicable Taxes referred to in the preceding clauses (A),
(B) or (C), 
 (ii) with respect to any payment of the principal of (including the Fundamental Change
Repurchase Price, Repurchase Price and Redemption Price, if applicable), premium, if any, and interest on, such Note to a Holder, if the Holder is a fiduciary, partnership or person other than the sole beneficial owner of that payment to the extent
that such payment would be required to be included in the income under the laws of the Relevant Taxing Jurisdiction, for tax purposes, of a beneficiary or settlor with respect to the fiduciary, a member of that partnership or a beneficial owner who
would not have been entitled to such Additional Amounts had that beneficiary, settlor, partner or beneficial owner been the Holder thereof. 

  
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 In addition to the foregoing, the Issuer shall also pay and indemnify the Holder for any
present or future stamp, issue, registration, value added, court or documentary taxes, or any other excise or property taxes, charges or similar levies or taxes (including penalties, interest and any other reasonable expenses related thereto) which
are levied by any Relevant Taxing Jurisdiction on the execution, delivery, registration or enforcement of any of the Notes, the Indenture or any other document or instrument referred to therein or the receipt of payments with respect thereto.

 In the event that the Issuer or the Guarantor become after the Issue Date obligated to pay Additional Amounts with respect to
any payment under or with respect to the Notes, the Issuer shall deliver to the Trustee on a date that is at least 30 days prior to the date of that payment (unless the obligation to pay Additional Amounts arises after the 30th day prior to that
payment date, in which case the Issuer shall notify the Trustee promptly thereafter) an Officer’s Certificate stating the fact that Additional Amounts will be payable and the amount estimated to be so payable. The Officer’s Certificate
must also set forth any other information reasonably necessary to enable the Paying Agent or the Exchange Agent, as the case may be, to pay Additional Amounts to Holders on the relevant payment date. The Trustee shall be entitled to rely solely on
such Officer’s Certificate as conclusive proof that such payments are necessary. The Issuer shall provide the Trustee with documentation reasonably satisfactory to the Trustee evidencing the payment of Additional Amounts. 

The Issuer or the Guarantor, as appropriate, shall make all withholdings and deductions required by law and shall remit the full amount
deducted or withheld to the Relevant Taxing Authority in accordance with applicable law. Upon request, the Issuer shall provide to the Trustee an official receipt or, if official receipts are not obtainable, other documentation reasonably
satisfactory to the Trustee evidencing the payment of any Applicable Taxes so deducted or withheld. The Issuer will attach to each certified copy or other document a certificate stating the amount of such Applicable Taxes paid per $1,000 principal
amount of the Notes then outstanding. Upon written request, copies of those receipts or other documentation, as the case may be, shall be made available by the Trustee to the Holders of the Notes. 

Any reference in this Indenture or the Notes in any context to the payment of cash and/or the delivery of ADSs (together with payments of
cash for fractional ADSs) upon exchange of the Notes or the payment of principal of (including Fundamental Change Repurchase Price, Repurchase Price and Redemption Price, if applicable), and any premium or interest, including any Additional
Interest, on, any Note or any other amount payable with respect to such Note, shall be deemed to include payment of Additional Amounts provided for in the Indenture to the extent that, in such context, Additional Amounts are, were or would be
payable in respect thereof. 
 The above obligations in this Section 4.16 will survive termination, defeasance or discharge
of this Indenture or any transfer by a Holder or beneficial owner of its Notes and will apply mutatis mutandis to any successor to the Issuer. 
 Section 4.17 Listing of the Notes. The Issuer will use its commercially reasonable efforts to procure the listing of the Notes on the Global Exchange Market operated under the supervision of
the Irish Stock Exchange (or on another recognized stock exchange for the purposes of Section 64 of the Taxes Consolidation Act 1997 of Ireland and within the meaning of Section 1005 ITA 2007 of the United Kingdom) prior to the first
Interest Payment Date. Additionally, the Issuer will use its commercially reasonable efforts to maintain the listing of the Notes on the Global Exchange Market operated under the supervision of the Irish Stock Exchange, provided that if at any time
the Issuer determines that it will not maintain such a listing, it will use its commercially reasonable efforts to maintain a listing of the Notes on another recognized stock exchange for the purposes of Section 64 of the Taxes Consolidation
Act 1997 of Ireland and within the meaning of Section 1005 ITA 2007 of the United Kingdom. Notwithstanding the foregoing, in the event that no withholding or deduction for or on account of Applicable Taxes by a Relevant Taxing Jurisdiction is
reasonably expected to be required on payments and/or deliveries on the Notes if the Notes are not so listed on any such recognized stock exchange, the Issuer will be under no obligation to so list (or maintain the listing of) them on any such
recognized stock exchange. 

  
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 ARTICLE 5. 
 REDEMPTION 
 Section 5.01 Redemption 

(a) Redemption for Tax Reasons. The Issuer may, at its option, offer to redeem the Notes, in whole but not in part
(except in respect of certain Excluded Holders), at a price (the “Tax Redemption Price”) payable in cash and equal to 100% of the principal amount of the Notes plus accrued and unpaid interest, including Additional Interest,
if any, to, but excluding, the Tax Redemption Date, and including, for the avoidance of doubt, any Additional Amounts with respect to such Tax Redemption Price, if the Issuer has, or on the next Interest Payment Date would, become obligated to pay
to the Holders Additional Amounts (that are more than a de minimis amount) as a result of any change or amendment occurring on or after the date of the Offering Memorandum in the laws or any rules or regulations of a Relevant Taxing
Jurisdiction or any change or amendment on or after the date of the Offering Memorandum in an interpretation, administration or application of such laws, rules or regulations by any legislative body, court, governmental agency, taxing authority or
regulatory or administrative authority of such Relevant Taxing Jurisdiction (including the enactment of any legislation and the formal announcement or publication of any judicial decision or regulatory or administrative interpretation or
determination but excluding the publication of guidance by the Irish Revenue Commissioners relating to their interpretation of Section 110 of the Irish Taxes Consolidation Act 1997 which was under discussion at December 31, 2011) (a
“Change in Tax Law” and such redemption, a “Tax Redemption”); provided, that the Issuer may only elect a Tax Redemption if (x) the Issuer cannot avoid these obligations by taking commercially reasonable
measures available to it and (y) the Issuer delivers to the Trustee an opinion of outside legal counsel of recognized standing in the Relevant Taxing Jurisdiction and an Officer’s Certificate attesting to such Change in Tax Law and
obligation to pay Additional Amounts; provided further, that if the Redemption Date occurs after a Regular Record Date and on or prior to the corresponding Interest Payment Date, the interest, including Additional Interest, if any, payable in
respect of such Interest Payment Date shall be payable to the Holders of record at the Close of Business on the corresponding Regular Record Date, and the Redemption Price payable to the Holder whose Note is redeemed will be equal to 100% of the
principal amount of such Note, including, for the avoidance of doubt, any Additional Amounts with respect to such Redemption Price. 
 (b) Optional Redemption. The Notes may be redeemed in whole or in part at the option of the Issuer on or after January 19, 2017 (such redemption, an “Optional Redemption”) at
a price (the “Optional Redemption Price”) payable in cash and equal to 100% of the principal amount of the Notes plus accrued and unpaid interest, including Additional Interest, if any, to, but excluding the Optional
Redemption Date, or, in the case of a Default by the Issuer in the payment of the Optional Redemption Price, the day on which such Default is no longer continuing; provided, however, that if the Notes are redeemed on a date that is after a
Regular Record Date and prior to the corresponding Interest Payment Date, the accrued interest payable in respect of such Interest Payment Date shall not be payable to Holders of the Notes to whom the principal amount of the Notes being redeemed
pursuant to the Optional Redemption is paid, and shall instead pay the full amount of the relevant interest payment on such Interest Payment Date to the Holder of record on the relevant Regular Record Date for the corresponding Interest Payment
Date. For the avoidance of doubt, the Issuer may not redeem any Notes in an Optional Redemption unless all accrued and unpaid interest thereon has been or is simultaneously paid (or will be paid at the next Interest Payment Date in accordance with
the immediately preceding sentence) for all semi-annual interest periods or portions thereof terminating prior to the Redemption Date. 
 (c) No Notes may be redeemed in a Tax Redemption or an Optional Redemption if the principal amount of the Notes has been accelerated, and such acceleration has not been rescinded, on or prior to the
Redemption Date (except in the case of an acceleration resulting from a Default by the Issuer in the payment of the Redemption Price with respect to such date). 

(d) Notwithstanding anything to the contrary herein, the Issuer may not redeem the Notes in the case that Additional
Amounts are, or as a result of a Change in Tax Law would be, payable in respect of United Kingdom or Irish withholding tax if no Additional Amounts would be payable if the Notes were listed on a recognized stock exchange for the United Kingdom or
Irish tax purposes, as appropriate, on the next Interest Payment Date. 

  
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 Section 5.02 Notice of Tax Redemption and Notice of Optional Redemption.

 (a) At least 30 Scheduled Trading Days but not more than 60 Scheduled Trading Days prior to a Redemption Date
in connection with a Tax Redemption or an Optional Redemption, the Issuer shall provide a notice of redemption to each Holder of Notes to be redeemed (a “Notice of Tax Redemption” or a “Notice of Optional
Redemption,” as applicable); provided that, as long as the Notes are held through the Depositary, such notice may be made by electronic transmission to the Depositary, as Holder. 

The Notice of Tax Redemption and the Notice of Optional Redemption shall specify the Notes to be redeemed and shall state: 

(i) the Redemption Date; 
 (ii) the Redemption Price; 
 (iii) the applicable Exchange Rate
and applicable Exchange Price; 
 (iv) the name and address of the Paying Agent and the Exchange Agent;

 (v) that Notes offered to be redeemed may be exchanged at any time before the Close of Business on the
Business Day immediately preceding the Redemption Date or, if the Issuer fails to pay the Redemption Price, such later date on which the Issuer pays the Redemption Price; 

(vi) that Holders who want to exchange Notes must satisfy the requirements set forth therein and in this Indenture;

 (vii) in the case of a Tax Redemption, that Holders have the right to elect not to have their Notes redeemed
by delivery to the Paying Agent a Notice of Tax Redemption Election; 
 (viii) in the case of a Tax Redemption,
that Holders who wish to elect not to have their Notes redeemed or to withdraw such an election must satisfy the requirements set forth herein and in the Indenture; 

(ix) in the case of a Tax Redemption, that, at and after the Redemption Date, Holders who elect not to have their Notes
redeemed will not receive any Additional Amounts on any payments with respect to such Notes solely as a result of the Change in Tax Law that resulted in the obligation to pay such Additional Amounts (whether upon exchange, required repurchase in
connection with a Fundamental Change or Optional Put, maturity or otherwise, and whether in cash, Ordinary Shares, Reference Property or otherwise) after the Redemption Date (or, if the Issuer fails to pay the Redemption Price, such later date on
which the Issuer pays the Redemption Price), and all future payments with respect to such Notes will be subject to the deduction or withholding of such Relevant Taxing Jurisdiction taxes required by law to be deducted or withheld as a result of such
Change in Tax Law, provided that, notwithstanding the foregoing, if a Holder electing not to have its Notes redeemed exchanges its Notes in connection with such Tax Redemption, the Issuer shall be obligated to pay such Additional Amounts, if any,
with respect to such exchange; 
 (x) that Notes offered to be redeemed must be surrendered to the Paying Agent
for cancellation to collect the Redemption Price; 

  
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 (xi) that, unless the Issuer defaults in making payment of such Redemption
Price, interest will cease to accrue with respect to redeemed Notes on and after the Redemption Date; 
 (xii)
the CUSIP number of the Notes; 
 (xiii) in the case of a Tax Redemption, if Holders would be entitled to
Additional Shares upon exchange in connection with such Tax Redemption, that Holders would be so entitled and a description of the method for determining the amount by which the Exchange Rate has been, or would be, so increased (along with a
description of how such increase is calculated and the time period during which Notes must be surrendered in order to be entitled to such increase); 
 (xiv) if fewer than all the outstanding Notes are to be redeemed pursuant to an Optional Redemption, the certificate numbers (if such Notes are held other than in global form) and principal amounts of the
particular Notes to be redeemed. 
 (b) Simultaneously with providing such Notice of Tax Redemption or Notice of
Optional Redemption, as applicable, the Issuer shall publish a notice containing this information in a newspaper of general circulation in the City of New York or publish the information on the Issuer’s website or through such other public
medium as the Issuer may use at that time. If Holders would be entitled to Additional Shares upon exchange in connection with such Tax Redemption, each such press release shall also state the fact that Holders would be so entitled to Additional
Shares and a description of the method for determining the applicable Redemption Reference Price and Redemption Reference Date. 
 (c) At the Issuer’s written request delivered at least 3 days prior to the date such Notice of Tax Redemption or Notice of Optional Redemption is to be given (unless a shorter period shall be
acceptable to the Trustee), the Trustee shall give Notice of Tax Redemption or Notice of Optional Redemption, as applicable, as prepared by the Issuer, to each Holder of Notes to be redeemed in the Issuer’s name and at the Issuer’s
expense. 
 Section 5.03 Holder’s Right to Elect. 

(a) Upon receiving a Notice of Tax Redemption, each Holder shall have the right to elect to not have its Notes redeemed,
in which case the Issuer will not be obligated to pay any Additional Amounts on any payment with respect to such Notes solely as a result of the Change in Law that resulted in the obligation to pay such Additional Amounts (whether upon exchange,
required repurchase in connection with a Fundamental Change or Optional Put, maturity or otherwise, and whether in cash, ADSs, Ordinary Shares, Reference Property or otherwise) after the Redemption Date (or, if the Issuer fails to pay the Redemption
Price on the Redemption Date, such later date on which the Issuer pays the Redemption Price), and all future payments with respect to such Notes will be subject to the deduction or withholding of such Relevant Taxing Jurisdiction taxes required by
law to be deducted or withheld as a result of such Change in Tax Law; provided that, notwithstanding the foregoing, if a Holder electing not to have its Notes redeemed exchanges its Notes in connection with such Tax Redemption as set forth under
Section 7.09, the Issuer shall be obligated to pay Additional Amounts, if any, with respect to such exchange. 
 (b) Upon receiving a Notice of Tax Redemption, each Holder who does not wish to have the Issuer redeem its Notes pursuant to this Article 5 (any such Holder, an “Excluded Holder”) must
deliver to the Paying Agent a written notice of election (the “Notice of Tax Redemption Election”) substantially in the form of Exhibit C hereto, or any other form of written notice substantially similar to the Notice of Tax
Redemption Election, in each case, duly completed and signed, so as to be received by the Paying Agent no later than the Close of Business on the Business Day immediately preceding the Redemption Date; provided that, a Holder that complies
with the requirements for exchange set forth under Section 7.02 will be deemed to have delivered a Notice of Tax Redemption Election. A Holder may withdraw any Notice of Tax Redemption Election (other than such a deemed Notice of Tax Redemption
Election) by delivering to the Paying Agent a written notice of withdrawal prior to the Close of Business on the Business Day immediately preceding the Redemption Date (or, if the Issuer fails to pay the Redemption Price on the Redemption Date, such
later date on which the Issuer pays the Redemption Price). If no such election is made or deemed to have been made, the Holder will have its Notes redeemed without any further action. 

  
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 Section 5.04 Effect of Notice of Tax Redemption and Notice of Optional
Redemption. Once a Notice of Tax Redemption or a Notice of Optional Redemption is given, Notes offered to be redeemed become due and payable on the Redemption Date and at the Redemption Price stated in such notice, except for Notes which are
exchanged in accordance with the terms of this Indenture and except for Notes subject to Section 5.03. Upon surrender to the Paying Agent, such redeemed Notes shall be paid at the Redemption Price stated in the Notice of Tax Redemption or
Notice of Optional Redemption. Failure to give the Notice of Tax Redemption or Notice of Optional Redemption or any defect in such notice to any Holder shall not affect the validity of such notice to any other Holder. 

Section 5.05 Deposit of Redemption Price. Prior to 10:00 a.m. (New York City time) on a Redemption Date, the Issuer shall
deposit with the Paying Agent (or if the Issuer is the Paying Agent, shall segregate and hold in trust) money sufficient to pay the Redemption Price of all Notes to be redeemed on that date other than Notes or portions of Notes to be redeemed which
on or prior thereto have been delivered by the Issuer to the Trustee for cancellation or have been exchanged. The Paying Agent shall as promptly as practicable return to the Issuer any money not required for that purpose because of exchange of Notes
pursuant to Article 7. If such money is then held by the Issuer in trust and is not required for such purpose it shall be discharged from such trust. 
 If the Paying Agent holds money sufficient to pay the Redemption Price with respect to any Notes (i) for which a Notice of Tax Redemption has been given and with respect to which a Notice of Tax
Redemption Election has not been made or deemed to have been made or (ii) for which a Notice of Optional Redemption has been given, then, immediately on and after the Redemption Date, interest on such Notes shall cease to accrue whether or not
the Notes are delivered to the Paying Agent, and all other rights of the Holders of such Notes shall terminate, other than the right to receive the Redemption Price of such Note, including Additional Amounts, if any, with respect thereto. Nothing
herein shall preclude the withholding of any taxes required by law to be withheld or deducted. 
 Section 5.06 Notes
Redeemed in Part. If the Issuer elects to redeem fewer than all of the outstanding Notes, the Trustee will select the Notes to be redeemed (such that the principal amount of a Holder’s Note not to be redeemed equals $200,000 or an integral
multiple of $1,000 in excess thereof) by lot, or on a pro rata basis, in all cases in accordance with the Applicable Procedures. Upon surrender of a Note that is redeemed in part pursuant to an Optional Redemption, the Issuer shall execute, and the
Trustee shall authenticate and deliver to the Holder, a new Note in an authorized denomination, which shall be $200,000 principal amount or an integral multiple of $1,000 in excess thereof, equal in principal amount to the unredeemed portion of the
Note surrendered. The Issuer shall not be required to (i) issue, register the transfer of or exchange any Notes during a period beginning at the Open of Business 15 days before any selection for redemption of Notes and ending at the Close of
Business on the earliest date on which the relevant Notice of Optional Redemption is deemed to have been given to all Holders of Notes to be redeemed or (ii) register the transfer of or exchange any Notes so selected for redemption, in whole or
in part, except the unredeemed portion of any Notes being redeemed in part. 
 If the Trustee selects a portion of a
Holder’s Notes for Optional Redemption and the Holder exchanges a portion of such Holder’s Notes, the exchanged portion of such Holder’s Notes shall be deemed to be from the portion selected for redemption, except to the extent of the
excess, if any, of such exchanged portion over such portion selected for redemption. 
 ARTICLE 6. 

[RESERVED] 

ARTICLE 7. 

EXCHANGE 

Section 7.01 Right to Exchange. Subject to and upon compliance with the provisions of this Indenture, a Holder will have the
right, at such Holder’s option, to exchange its Notes, or any portion so long as the principal amount of such Holder’s Notes not exchanged equals $200,000 or an integral multiple of $1,000 in excess thereof, into an amount of cash, a
number of ADSs or a combination of cash and ADSs, as the case may be, determined in 

  
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accordance with Section 7.03 hereof, based on an Exchange Rate initially equal to 113.4752 ADSs (equivalent to an initial Exchange Price of approximately $8.8125) (and subject to adjustment
as provided in this Article 7) per $1,000 principal amount of Notes (the “Exchange Rate”) (i) prior to the Close of Business on the Business Day immediately preceding October 15, 2031, only upon satisfaction of one or
more of the conditions set forth in Section 7.01(a), (b), (c), (d) and (e) and (ii) on or after October 15, 2031, at any time prior to the Close of Business on the second Scheduled Trading Day immediately preceding the
Maturity Date. 
 (a) Exchange upon Satisfaction of Sale Price Condition. A Holder may surrender all or a
portion of its Notes for exchange during any calendar quarter commencing after March 31, 2012 (and only during such calendar quarter), if the Last Reported Sale Price of the ADSs for at least 20 Trading Days (whether or not consecutive) during
the period of 30 consecutive Trading Days ending on the last Trading Day of the immediately preceding calendar quarter is greater than or equal to 130% of the Exchange Price in effect on each applicable Trading Day. 

(b) Exchange upon Satisfaction of Trading Price Condition. A Holder may surrender its Notes for exchange at any
point during the five Business Day period after any five consecutive Trading Day period (the “Measurement Period”) in which the Trading Price per $1,000 principal amount of Notes, as determined following a request by a Holder in
accordance with the procedures set forth herein, for each Trading Day of that Measurement Period was less than an amount equal to 98% of the product of (x) the Last Reported Sale Price of the ADSs on such Trading Day and (y) the Exchange
Rate in effect on such Trading Day. 
 The Bid Solicitation Agent shall have no obligation to determine the Trading Price of the
Notes unless the Issuer has requested such determination; and the Issuer shall have no obligation to make such request unless a Holder (or beneficial holder of a Note) of at least $3.0 million principal amount provides the Issuer with reasonable
evidence that the Trading Price per $1,000 principal amount of Notes would be less than 98% of the product of the Last Reported Sale Price of the ADSs on the next Trading Day and the Exchange Rate in effect on such Trading Day. At such time, the
Issuer shall instruct the Bid Solicitation Agent to determine the Trading Price per $1,000 principal amount of the Notes beginning on the next Trading Day and on each successive Trading Day until the Trading Price per $1,000 principal amount of
Notes is greater than or equal to 98% of the product of the Last Reported Sale Price of the ADSs on such Trading Day and Exchange Rate in effect on such Trading Day. In addition, the Issuer shall provide written notice to the Bid Solicitation Agent
(if other than the Issuer) of the three independent nationally recognized securities dealers selected by the Issuer in accordance with the definition of Trading Price, along with the appropriate contact information for each. Whenever the condition
to exchange set forth in this Section 7.01(b) has been met, but was not met on the immediately preceding Trading Day, the Issuer will so notify the Holders and the Trustee in writing. If, at any time after the condition to exchange set forth in
this Section 7.01(b) has been met, the condition to exchange set forth in this Section 7.01(b) ceases to be met, the Issuer will so notify the Holders and the Trustee on the first Trading Day on which such condition ceases to be met. The
Bid Solicitation Agent, the Exchange Agent and the Trustee shall have no obligation to determine the Trading Price of the Notes. 
 (c) Exchange upon Specified Corporate Events. 
 (i)
Certain Distributions. If the Guarantor elects to: 
 (A) issue to all or substantially all holders of
the Ordinary Shares or ADS rights, options or warrants entitling such holders for a period of not more than 45 calendar days after the Issue Date of such issuance to subscribe for or purchase Ordinary Shares, at a price per Ordinary Share less than
the average of the Last Reported Sale Prices of the ADSs (divided by the number of Ordinary Shares represented by one ADS on each such Trading Day), or to subscribe for or purchase the ADSs, at a price per ADS less than the average of the
Last Reported Sale Prices of the ADSs, in each case, over the 10 consecutive Trading Day period ending on the Trading Day immediately preceding the date of announcement of such issuance; or 

  
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 (B) distribute to all or substantially all holders of the Ordinary Shares
or ADSs, the Guarantor’s assets, debt securities or rights to purchase securities of the Guarantor, which distribution has a per Ordinary Share value, as reasonably determined by the Guarantor’s Board of Directors, exceeding 10% of the
Last Reported Sale Price of the ADSs (divided by the number of Ordinary Shares represented by one ADS on such Trading Day), or a per ADS value, as reasonably determined by the Board of Directors, exceeding 10% of the Last Reported Sale Price
of the ADSs, in each case, on the Trading Day preceding the date of announcement for such distribution, 
 then, in either case,
the Issuer shall notify the Holders not less than 35 Scheduled Trading Days prior to the Ex-Dividend Date for such issuance or distribution. Once the Issuer gives such notice, Holders may surrender their Notes for exchange at any time until the
earlier of (x) the Close of Business on the Business Day immediately preceding the Ex-Dividend Date and (y) the Guarantor’s announcement that such issuance or distribution will not take place, even if the Notes are not otherwise
exchangeable at such time. 
 (ii) Certain Corporate Events. If (A) a transaction or event that
constitutes a Fundamental Change or a Make-Whole Fundamental Change occurs, regardless of whether a Holder has the right to require the Issuer to repurchase the Notes pursuant to Section 8.01(a) in connection with such transaction or event, or
(B) the Guarantor is a party to (x) a consolidation, merger or binding share exchange pursuant to which Ordinary Shares or ADSs would be exchanged into cash, securities or other assets or (y) a transfer or lease of all or
substantially all of the Issuer’s assets, in each case, the Notes may be surrendered for exchange at any time from or after the date which is 35 Scheduled Trading Days prior to the anticipated effective date of the transaction (or, if later,
the Business Day after the Issuer gives notice of such transaction) until the earlier of (i)(a) if such transaction does not constitute a Fundamental Change, the Close of Business 35 Business Days after the actual effective date of such
transaction and (b) if such transaction constitutes a Fundamental Change, the Close of Business on the Business Day immediately preceding the related Fundamental Change Repurchase Date, and (ii) the Issuer’s announcement that such
transaction will not take place. The Issuer shall notify Holders and the Trustee in writing (I) as promptly as practicable following the date on which the Issuer publicly announces such transaction but in no event less than 35 Scheduled Trading
Days prior to the anticipated effective date of such transaction, or (II) if the Guarantor does not have knowledge of such transaction or its anticipated effective date at least 35 Scheduled Trading Days prior to the anticipated effective date
of such transaction, within one Business Day of the date upon which the Guarantor receives notice, or otherwise becomes aware, of such transaction and its anticipated effective date, but in no event later than the actual effective date of such
transaction. Simultaneously with providing any such notice, the Issuer shall issue a press release containing the relevant information and make such information available on its website. 

(d) Exchange upon Notice of Tax Redemption. If the Issuer has provided a Notice of Tax Redemption, Holders will
have the right to exchange their Notes and the Issuer shall issue a press release on such date pursuant to Section 5.02(b). In connection with the Issuer’s election to effect a Tax Redemption, a Holder may surrender Notes for exchange at
any time from, and including, the date on which the Issuer provides such Notice of Tax Redemption to Holders until the Close of Business on the Business Day immediately preceding the applicable Tax Redemption Date or, if the Issuer fails to pay the
Redemption Price, such later date on which the Issuer pays the Redemption Price. For the avoidance of doubt, a Holder may be entitled to Additional Shares pursuant to Section 7.09. In no event shall the Trustee be liable in respect of any
payment of the Redemption Price (including as to timing, correctness of amount, entitlement to receive or any other matters relating to such payment) arising from or related to the ability of Holders to surrender Notes for exchange during the period
specified above in connection with the Issuer’s election to effect a Tax Redemption. 
 (e) Exchange
upon Notice of Optional Redemption. If the Issuer has provided a Notice of Optional Redemption scheduling an Optional Redemption Date on or after January 19, 2017 pursuant to Section 5.02(a), Holders will have the right to exchange
their Notes and the Issuer shall issue a press release on such date pursuant to Section 5.02(b). In connection with the Issuer’s election to effect an 

  
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Optional Redemption, a Holder may surrender Notes for exchange at any time from, and including the date on which the Issuer provides such Notice of Optional Redemption until the Close of Business
on the Business Day immediately preceding the applicable Optional Redemption Date or, if the Issuer fails to pay the Redemption Price, such later date on which the Issuer pays the Redemption Price. In no event shall the Trustee be liable in respect
of any payment of the Redemption Price (including as to timing, correctness of amount, entitlement to receive or any other matters relating to such payment) arising from or related to the ability of Holders to surrender Notes for exchange during the
period specified above in connection with the Issuer’s election to effect an Optional Redemption. 
 (f)
Exchange on or after October 15, 2031. Notwithstanding the foregoing conditions set forth in this Section 7.01, on or after October 15, 2031, Holders will have the right to exchange their Notes at any time prior to the Close of
Business on the second Scheduled Trading Day immediately preceding the Maturity Date. 
 Section 7.02 Exchange
Procedures. 
 (a) General. To exercise its exchange privilege with respect to a beneficial interest
in a Global Note or with respect to a Physical Note, the Holder of such Note must: 
 (i) pay any funds required
under Section 7.02(d) hereof; 
 (ii) pay any taxes or duties required under the proviso of
Section 7.02(e) hereof; and 
 (iii) if such Note is a Global Note, (A) complete any instruction form
required by the Depositary to effect the exchange of a beneficial interest under the Applicable Procedures; and (B) otherwise comply with the Applicable Procedures of the Depositary in effect on the date such Holder seeks to exchange such
beneficial interest; or 
 (iv) if such Note is a Physical Note, (A) complete and manually sign the
exchange notice on the back of the Note (the “Exchange Notice”), or a facsimile of the Exchange Notice; (B) deliver the Exchange Notice (or facsimile thereof), which is irrevocable, and the Note to the Exchange Agent; and,
(C) if required, furnish appropriate endorsements and transfer documents. 
 In addition, if a Holder has already delivered
a Fundamental Change Repurchase Notice or Repurchase Notice with respect to a Note in accordance with Section 8.04 hereof, except to the extent that a portion of such Note is not subject to a Fundamental Change Repurchase Notice or Repurchase
Notice, the Holder may not surrender that Note for exchange until the Holder has withdrawn the Fundamental Change Repurchase Notice in accordance with Section 3.04 of this Indenture or Optional Put Notice in accordance with Section 8.03 of
this Indenture. 
 The first Business Day on which a Holder complies with the relevant procedures for exchange set forth in
clauses (i) through (iv) above and any other procedures required to effect a exchange under this Indenture shall be the “Exchange Date” with respect to such Note, and any exchange of a Note will be deemed to occur at the
Close of Business on the Exchange Date applicable to such Note. If, at any time, the last date on which any Note may be exchanged is not a Business Day, such Note may be exchanged on the immediately following Business Day. 

(b) Holder of Record. If a Holder surrenders the entire principal amount of a Note for exchange, as of the Close
of Business on the applicable Exchange Date, such Person will no longer be the Holder of such Note. If any ADSs are issuable upon the exchange of a Note, except as provided under Sections 7.05(g) and 7.06(f) hereof, the Person in whose name
such ADSs will be registered will become the holder of record of such ADSs (i) if Physical Settlement applies to such Note, at the Close of Business on the Exchange Date, and (ii) if Combination Settlement applies to such Note, at the
Close of Business on the last VWAP Trading Day of the relevant Observation Period. 
 (c) Exchanges in
Part. If a Holder surrenders only a portion of the principal amount of a Physical Note for exchange, promptly after the applicable Exchange Date, the Issuer, in accordance with 

  
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Section 3.04, will execute, and the Trustee, in accordance with Section 3.04, will authenticate and deliver to such Holder, one or more new Physical Notes, each in an authorized
denomination and having an aggregate principal amount equal to the unexchanged portion of the Physical Note exchanged in part. Upon the exchange of any beneficial interest in a Global Note, the Exchange Agent will promptly request that the Trustee
make a notation on the “Schedule of Increases and Decreases of Global Note” of such Global Note to reduce the principal amount represented by such Global Note by the principal amount of the exchanged beneficial interest. 

(d) Reimbursement of Interest upon Exchange. If a Holder surrenders a Note for exchange during the period from the
Close of Business on a Regular Record Date to the Open of Business on the corresponding Interest Payment Date, such Holder must accompany such Note with an amount of cash equal to the amount of interest that will be payable on such Note on the
corresponding Interest Payment Date; provided, however, that a Holder need not make such payment (A) if the Exchange Date follows the Regular Record Date immediately preceding the Maturity Date; (B) if the Issuer has specified a
Redemption Date, Fundamental Change Repurchase Date or Repurchase Date that is after a Regular Record Date and on or prior to the Business Day immediately following the corresponding Interest Payment Date; or (C) to the extent of any overdue
interest, if any overdue interest exists at the time of exchange with respect to such Note. 
 (e) Taxes Due
upon Exchange. If a Holder exchanges a Note, the Issuer will pay any documentary, stamp or similar issue or transfer tax (“Transfer Taxes”) due on the issue of any ADSs upon the exchange (including any Transfer Taxes due on the
issue or transfer of any Ordinary Shares represented by such ADSs), unless the tax is due because the Holder requests that any ADSs be issued in a name other than the Holder’s name, in which case the Holder will pay that tax. 

(f) Notice of Tax Redemption. If the Issuer has designated a Tax Redemption Date pursuant to Section 5.01(a),
a Holder that complies with the requirements for exchange described in this Section 7.02 will be deemed to have delivered a notice of its election not to have its Notes so redeemed pursuant to a Tax Redemption. 

Section 7.03 Settlement Upon Exchange. 

(a) Settlement Methods. Except to the extent otherwise provided in Sections 7.05(f), 7.05(g), 7.05(h),
7.05(i), 7.06(f) and 7.07 hereof, if a Holder exchanges a Note, a cash amount, calculated in accordance with Sections 7.03(a)(i), 7.03(a)(ii) or 7.03(a)(iii) below, depending upon which Settlement Method applies to such Note (a “Liquidated
Sum”), shall be payable by the Issuer to the Holder, and the Issuer will satisfy its obligation in respect of the Liquidated Sum by paying or delivering, as the case may be, cash (a “Cash Settlement”), ADSs, together with
cash in lieu of any fractional ADS (a “Physical Settlement”), or a combination of cash and ADSs, together with cash in lieu of any fractional ADSs (a “Combination Settlement,” and each of Cash Settlement, Physical
Settlement and Combination Settlement, a “Settlement Method,” and the obligation to effect such payment and/or delivery, the “Exchange Obligation”), based on the Settlement Method that applies to the Note and the
Exchange Rate in effect on the applicable Exchange Date, in each case, as follows: 
 (i) Physical
Settlement. If Physical Settlement applies to a Note, the Issuer will deliver to the Holder of such Note a number of ADSs equal to the product of (A)(x) the aggregate principal amount of such Note that is being exchanged, divided by
(y) $1,000 and (B) the Exchange Rate in effect on the applicable Exchange Date; provided, however, that the Issuer will pay an amount of cash in lieu of any fractional ADS determined in accordance with Section 7.03(a)(iv)
hereof. The Issuer will deliver such ADSs, and pay any amount of cash in lieu of any fractional ADS, on the third Business Day immediately following the applicable Exchange Date. 

(ii) Cash Settlement. If Cash Settlement applies to a Note, the Issuer will pay to the Holder of such Note an
amount of cash equal to the product of (A)(x) the aggregate principal amount of such Note that is being exchanged, divided by (y) $1,000, and (B) the sum of the Daily Exchange Values for each of the twenty-five
(25) consecutive VWAP Trading Days in the applicable Observation Period. The Issuer shall pay such amount of cash on the third Business Day immediately following the last VWAP Trading Day of such Observation Period. 

  
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 (iii) Combination Settlement. If Combination Settlement applies to a
Note, the Issuer will pay or deliver, as the case may be, to the Holder of such Note, the product of (A)(x) the aggregate principal amount of such Note that is being exchanged, divided by (y) $1,000, and (B) the sum of the
Daily Settlement Amounts for each of the twenty-five (25) consecutive VWAP Trading Days in the applicable Observation Period; provided, however, that the Issuer will pay an amount of cash in lieu of any fractional ADS determined in
accordance with Section 7.03(a)(iv) hereof. The Issuer shall pay or deliver, as the case may be, such amount of cash and number of ADSs on the third Business Day immediately following the last VWAP Trading Day of such Observation Period.

 (iv) Fractional ADS. If Physical Settlement or Combination Settlement applies to a Note and the
Issuer’s Exchange Obligation with respect to such Note includes a fractional ADS, in lieu of delivering such fractional ADS, the Issuer will pay the exchanging Holder, (A) if Physical Settlement applies to such Note, an amount of cash
equal to the product of (x) such fraction of an ADS and (y) the Daily VWAP on the applicable Exchange Date (or, if such Exchange Date is not a VWAP Trading Day, the immediately preceding VWAP Trading Day), and, (B) if Combination
Settlement applies to such Note, an amount of cash equal to the product of (x) such fraction of an ADS and (y) the Daily VWAP on the last VWAP Trading Day of the applicable Observation Period. 

(v) Exchange of Multiple Notes by a Single Holder. If a Holder surrenders more than one Note for exchange on a
single Exchange Date, the Issuer will calculate its Exchange Obligation with respect to such Notes as if such Holder had surrendered for exchange one Note having an aggregate principal amount equal to the sum of the principal amounts of each of the
Notes surrendered for exchange by such Holder on such Exchange Date. 
 (vi) Settlement of Accrued Interest
and Deemed Payment of Principal. Notwithstanding anything to the contrary in this Indenture, if a Holder exchanges a Note, the Issuer will not adjust the Exchange Rate to account for any accrued and unpaid interest on such Note and the
Issuer’s payment or delivery, as the case may be, of the amount of cash, number of ADSs or the amount of cash and the number of ADSs due as part of the Issuer’s Exchange Obligation with respect to such Note will be deemed to satisfy and
discharge in full the Issuer’s obligation to pay the principal of the Note and accrued and unpaid interest, if any, on, such Note to, but excluding, the Exchange Date; provided, however, that if a Holder exchanges a Note after the Close
of Business on a Regular Record Date but prior to the Open of Business on the corresponding Interest Payment Date, the Issuer will still be obligated to pay the interest due on such Interest Payment Date to the Holder of such Note at the Close of
Business on such Regular Record Date notwithstanding the exchange. 
 As a result, except as otherwise provided
in the proviso to the immediately preceding sentence, any accrued and unpaid interest with respect to an exchanged Note will be deemed to be paid in full rather than cancelled, extinguished or forfeited. In addition, if the Exchange Obligation for
any Note includes both cash and ADSs, accrued and unpaid interest will be deemed to be paid first out of the amount of cash delivered upon such exchange. 
 (b) Company’s Right to Elect the Settlement Method. Except to the extent otherwise provided in Section 7.06(f) hereof: 

(i) The Issuer shall use the same Settlement Method to settle every Note having a given Exchange Date that occurs before
October 15, 2031. 

  
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 (ii) The Issuer shall use the same Settlement Method to settle every Note
having any Exchange Date that occurs on or after October 15, 2031, regardless of whether such Notes have the same Exchange Date. 
 (iii) To elect the Settlement Method that will apply to every Note having a given Exchange Date that occurs before October 15, 2031, on or prior to the Close of Business on the Scheduled Trading Day
immediately following such Exchange Date, the Issuer shall deliver, to each Holder exchanging a Note on such date, through the Trustee, notice of the Settlement Method that will apply to every Note exchanged on such Exchange Date. 

(iv) To elect the Settlement Method that will apply to every Note having an Exchange Date on or after October 15,
2031, on or prior to the Close of Business on the Business Day immediately preceding October 15, 2031, the Issuer shall deliver, to the Trustee and through a press release containing the relevant information and by making such information
available on the Issuer’s website, notice of the Settlement Method that will apply to every Note having an Exchange Date on or after October 15, 2031. 

(v) Whenever the Issuer elects to settle Notes with a Combination Settlement, the notice electing such Settlement Method
must also state the maximum amount of cash that a Holder may receive (for any Combination Settlement, the “Specified Dollar Amount” for such Combination Settlement) per $1,000 principal amount of Notes that are subject to such
Combination Settlement. 
 (vi) If the Issuer fails to validly elect a Settlement Method (and Specified Dollar
Amount, if applicable) in accordance with this Section 7.03(b) that will apply (i) to every Note having a given Exchange Date that occurs before October 15, 2031 or (ii) every Note having an Exchange Date on or after
October 15, 2031, as the case may be, then Combination Settlement will apply to every Note exchanged on such Exchange Date or Exchange Dates, as the case may be, and the Specified Dollar Amount for such Combination Settlement will be deemed to
equal $1,000. 
 (vii) Notices. Whenever an Exchange Date occurs with respect to a Note, the Exchange
Agent will, as promptly as possible, and in no event later than 11:59 a.m., New York City time, on the Scheduled Trading Day immediately following such Exchange Date, deliver to the Issuer and the Trustee notice that an Exchange Date has occurred,
which notice will state such Exchange Date, the principal amount of Notes exchanged on such Exchange Date and the names of the Holders that exchanged Notes on such Exchange Date. 

On the first Business Day immediately following the last VWAP Trading Day of the Observation Period applicable to any
Exchange Date, the Issuer will deliver written notice to the Exchange Agent and the Trustee stating (A) the Daily Settlement Amounts (if Combination Settlement applies to the Notes exchanged on such Exchange Date) or the Daily Exchange Values
(if Cash Settlement applies to the Notes exchanged on such Exchange Date), in each case, for each VWAP Trading Day in such Observation Period, and (B) the amount of cash, the number of ADSs or the amount of cash and the number of ADSs, as the
case may be, that the Issuer is obligated to pay or deliver, as the case may be, to satisfy its Exchange Obligation with respect to each Note exchanged on such Exchange Date. 

(c) Notwithstanding the provisions described above in Sections 7.03(a) and 7.03(b), unless and until the Guarantor
receives shareholder approval of the issuance of the Notes in accordance with applicable listing standards of The NASDAQ Global Market, upon exchange of any Note in respect of which the Issuer has elected to satisfy the Exchange Obligation for such
Note in either Physical Settlement or Combination Settlement, 
 (i) in the case of Physical Settlement, the
Issuer will be deemed to have elected Combination Settlement with a Specified Dollar Amount of $0, and 

  
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 (ii) in the event that the Daily Share Amount for any VWAP Trading Day
during the Observation Period exceeds the Daily Share Cap, the Issuer will deliver an amount of cash in lieu of such excess ADSs equal to the product of (x) such excess ADSs and (y) the Daily VWAP of the ADSs on such VWAP Trading Day.

 If the Daily Share Cap applies to any exchange of the Notes, the Issuer will provide notice of the settlement
mechanism described in this Section 7.03(c) and the applicable Daily Share Cap to the Holder of such exchanged Notes and the Trustee prior to the Close of Business on the Business Day immediately following the Exchange Date for such exchanged
Notes through a press release containing the relevant information and by making such information available on the Issuer’s website. Notwithstanding the provisions in this Section 7.03(c), if the Guarantor obtains shareholder approval of
such an issuance prior to the issuing of a number of ADSs upon the exchange of the Notes that would exceed 19.99% of the number of ADSs outstanding on the date that the Notes are first issued, then there shall be no Daily Share Cap applicable to the
calculation of the Daily Settlement Amounts due upon exchange. 
 (d) Surrender to Financial Institution in
Lieu of Exchange. 
 Notwithstanding the provisions described above in this Section 7.03, in
satisfaction of the Exchange Obligation, the Issuer may, at its election (a “Financial Institution Surrender Election”), direct the Exchange Agent to surrender, on or prior to the second Business Day following the Exchange Date,
such Notes to one or more financial institutions designated by the Issuer (a “Financial Institution Surrender”) in lieu of exchange. In order to accept any Notes surrendered for a Financial Institution Surrender, the designated
financial institution(s) must agree to timely deliver, in exchange for such Notes, the cash, ADSs or combination of cash and ADSs, at the Issuer’s election, equal to the consideration due upon exchange (the “Exchange
Consideration”) pursuant to this Section 7.03, as is designated to the Exchange Agent in writing by the Issuer. By the Close of Business on the second Business Day following the relevant surrender date, the Issuer shall notify, in the
manner provided in this Section 7.03, the Holder surrendering Notes, the Exchange Agent and the Trustee, that the Issuer has made the Financial Institution Surrender Election and such financial institution(s) shall be required to notify the
Exchange Agent and such Holder whether it will deliver the Exchange Consideration upon surrender. If the designated financial institution(s) accept any such Notes, they shall deliver the Exchange Consideration in accordance with this
Section 7.03. Any Notes exchanged by the designated financial institution(s) shall remain outstanding. If the designated financial institution(s) agree to accept any Notes for surrender but do not timely deliver the related Exchange
Consideration, or if such designated financial institution(s) do not accept the Notes for surrender, the Issuer shall, no later than the third VWAP Trading Day immediately following the last VWAP Trading Day of the related Observation Period,
exchange the Notes into cash and, if applicable, the appropriate number of ADSs due upon exchange pursuant to this Section 7.03 as if the Issuer had not made an Financial Institution Surrender Election. The Issuer’s designation of a
financial institution to which the Notes may be submitted for a Financial Institution Surrender does not require such institution to accept any Notes. 
 (e) Certain provisions relating to English law. 
 In
respect of any ADSs which the Issuer proposes to deliver pursuant to Section 7.03(a)(i) and Section 7.03(a)(iii), the parties agree that 
 (i) the primary obligation of the Issuer is to pay to the Holder the Liquidated Sum; 
 (ii) in its performance under Section 15.01 of the Issuer’s obligation to deliver ADSs pursuant to Section 7.03(a)(i) and Section 7.03(a)(iii) (which is a Guarantee Obligation), the
Guarantor shall allot and issue to the Depositary such number of Ordinary Shares as is required to underlie the ADSs to be delivered pursuant to Section 7.03(a)(i) and Section 7.03(a)(iii) and shall procure the issue of such ADSs; and

  
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 (iii) the Ordinary Shares allotted and issued in accordance with
Section 7.03(e)(ii) shall, for the purposes of section 583 of the UK Companies Act 2006, be allotted and issued in consideration for the release of the liability of the Guarantor arising pursuant to this Indenture for the Liquidated Sum.

 Section 7.04 Certain Provisions Related to ADSs Issued Hereunder. 

(a) To the extent necessary to satisfy the Issuer’s and the Guarantor’s obligations under this Indenture, at
all times during the term of this Indenture, the Guarantor will use its best endeavours to maintain authority under sections 551 and 570 of the UK Companies Act to allot and issue, free from pre-emption rights or other third party rights, a number
of Ordinary Shares equal to the product of (i) the maximum number of ADSs potentially required to satisfy exchange of the Notes from time to time as Notes are presented for exchange and (ii) the number of Ordinary Shares represented by one
ADS at such time. 
 (b) Any Ordinary Shares represented by ADSs delivered hereunder (whether upon exchange,
under the terms of the Guarantee or otherwise) and any such ADSs, in each case, will be newly issued securities or treasury securities, duly and validly authorized and issued, fully paid, nonassessable, free from preemptive rights and free of any
lien or adverse claim (except to the extent of any lien or adverse claim created by the action or inaction of the Holder or other Person to whom such ADSs will be delivered) and will rank pari passu with and be identical to the Ordinary
Shares or ADSs (as the case may be) then in issue. 
 (c) In addition, the Guarantor covenants that, if any
Ordinary Shares represented by ADSs to be provided hereunder (whether upon exchange, under the terms of the Guarantee or otherwise) or any such ADSs, in either case, require registration with or approval of any governmental authority under any
federal or state law before such Ordinary Shares or such ADSs may be validly issued, the Guarantor will, to the extent then permitted by the rules and interpretations of the Commission, secure such registration or approval, as the case may be;
provided that, the Guarantor shall not be obligated to register the offer and sale of such Ordinary Shares or such ADSs under the Securities Act. 
 (d) The Guarantor will cause any ADSs issuable hereunder (whether upon exchange, under the terms of the Guarantee or otherwise) to be listed on whatever stock exchange(s) the ADSs are listed, if permitted
and required by the rules of such stock exchange(s), on the date the exchanging Holder becomes a record holder of such ADSs. 
 (e) The Guarantor shall, and shall procure that the ADS Depositary shall, at all times maintain, for the benefit of the Holders, a number of ADSs available for distribution under a registration statement
on Form F-6 equal to at least the maximum number of ADSs potentially required to satisfy exchange of the Notes from time to time as Notes are presented for exchange. 

(f) The Issuer and the Guarantor acknowledge that the allotment and issue of Ordinary Shares and the delivery of ADSs, if
any, hereunder (whether upon exchange, under the terms of the Guarantee or otherwise) by the Guarantor (or by the ADS Depositary at the direction of the Guarantor) to, or at the direction of, the Issuer will create an equivalent debt owing from the
Issuer to the Guarantor. 
 Section 7.05 Adjustment of Exchange Rate. 

If the number of Ordinary Shares represented by the ADSs is changed for any reason other than one or more of the events described in this
Section 7.05, the Issuer shall make an appropriate adjustment to the Exchange Rate such that the number of Ordinary Shares represented by the ADSs upon which exchange of the Notes is based remains the same. Such adjustment will be calculated to
the nearest 1/10,000th of an ADS. 
 Notwithstanding the adjustment provisions described in this Section 7.05, if the
Guarantor distributes to holders of the Ordinary Shares any cash, rights, options, warrants, shares of Capital Stock or similar equity interest, evidences of indebtedness or other assets or property of the Guarantor (but excluding Expiring Rights)
and a 

  
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corresponding distribution is not made to holders of the ADSs, but, instead, the ADSs shall represent, in addition to the Ordinary Shares, such cash, rights, options, warrants, shares of Capital
Stock or similar equity interest, evidences of indebtedness or other assets or property of the Guarantor, then an adjustment to the Exchange Rate described in this Section 7.05 in respect of such distribution shall not be made until and unless
a corresponding distribution (if any) is made to holders of the ADSs, and such adjustment to the Exchange Rate shall be based on the distribution made to the holders of the ADSs and not on the distribution made to the holders of the Ordinary Shares.

 However, in the event that the Guarantor issues or distributes to all holders of the Ordinary Shares any Expiring Rights,
notwithstanding the immediately preceding sentence, the Issuer shall adjust the Exchange Rate pursuant to Section 7.05(b) (in the case of Expiring Rights entitling holders of the Ordinary Shares for a period of not more than 45 calendar days
after the date of such issuance to subscribe for or purchase Ordinary Shares or ADSs) or Section 7.05(c) (in the case of all other Expiring Rights). “Expiring Rights” means any rights, options or warrants to purchase Ordinary
Shares or ADSs that expire on or prior to the Maturity Date. 
 For the avoidance of doubt, if any event described in this
Section 7.05 results in a change to the number of Ordinary Shares represented by the ADSs, then such a change shall be deemed to satisfy the Issuer’s obligation to effect the relevant adjustment to the Exchange Rate on account of such an
event to the extent to which such change reflects what a corresponding change to the Exchange Rate would have been on account of such an event. 
 The Issuer will adjust the Exchange Rate from time to time as described in this Section 7.05, except that the Issuer will not make an adjustment to the Exchange Rate for any transaction described in
this Section 7.05 (other than in the case of a share split or share combination) if each Holder has the right to participate, in such transaction at the same time and upon the same terms as holders of the ADSs and solely as a result of holding
the Notes, without having to exchange its Notes and as if it held a number of ADSs equal to the applicable Exchange Rate, multiplied by the principal amount (expressed in thousands) of Notes held by such Holder. 

(a) Stock Dividends and Share Splits. If the Guarantor exclusively issues Ordinary Shares as a dividend or
distribution on all or substantially all Ordinary Shares, or if the Guarantor effects an Ordinary Share split or Ordinary Share combination, the Exchange Rate will be adjusted based on the following formula: 

 

									
		 	ER1 =	 	ER0 ×	 	 OS1
	 	
	 	 	 	OS0	 	

  

					
	where:	  		  	
			
	ER0	  	=	  	the Exchange Rate in effect immediately prior to the Open of Business on the Ex-Dividend Date of such dividend or distribution, or immediately prior to the Open of Business on the
effective date of such Ordinary Share split or Ordinary Share combination, as applicable;
			
	ER1	  	=	  	the Exchange Rate in effect immediately after the Open of Business on such Ex-Dividend Date or effective date;
			
	OS0	  	=	  	the number Ordinary Shares outstanding immediately prior to the Open of Business on such Ex-Dividend Date or such effective date; and
			
	OS1	  	=	  	the number of Ordinary Shares outstanding immediately after giving effect to such dividend, distribution, Ordinary Share split or Ordinary Share combination.

 Any adjustment made under this Section 7.05(a) shall become effective immediately after the Open of Business on the
Ex-Dividend Date for such dividend or distribution, or immediately after the Open of Business on the effective date for such Ordinary Share split or Ordinary Share combination. If any dividend or distribution of the type described in this
Section 7.05(a) is declared but not so paid or made, the Exchange Rate shall be immediately 

  
 54 

 
readjusted, effective as of the date the Guarantor’s Board of Directors determines not to pay such dividend or distribution, to the Exchange Rate that would then be in effect if such
dividend or distribution had not been declared or announced. 
 (b) Rights, Options, and Warrants. If the
Guarantor issues to all or substantially all holders of Ordinary Shares or ADSs any rights, options or warrants entitling such holders for a period of not more than 45 calendar days after the date of such issuance to subscribe for or purchase
Ordinary Shares, at a price per share less than the average of the Last Reported Sale Prices of the ADSs (divided by the number of Ordinary Shares represented by one ADS on each such Trading Day), or to subscribe for or purchase ADSs, at a
price per ADS less than the average of the Last Reported Sale Prices of the ADSs, in each case, over the 10 consecutive Trading Day period ending on, and including, the Trading Day immediately preceding the date of announcement of such issuance, the
Exchange Rate will be increased based on the following formula: 
  

									
		 	ER1 =	 	ER0 ×	 	 OS0 + X
	 	
	 	 	 	OS0 + Y	 	

  

					
	where:	  		  	
			
	ER0	  	=	  	the Exchange Rate in effect immediately prior to the Open of Business on the Ex-Dividend Date for such issuance;
			
	ER1	  	=	  	the Exchange Rate in effect immediately after the Open of Business on such Ex-Dividend Date;
			
	OS	  	=	  	the number of Ordinary Shares outstanding immediately prior to the Open of Business on such Ex-Dividend Date;
			
	X	  	=	  	the total number of Ordinary Shares issuable pursuant to such rights, options or warrants; and
			
	Y	  	=	  	the number of Ordinary Shares equal to the aggregate price payable to exercise such rights, options or warrants divided by the average of the Last Reported Sale Prices of the
ADSs (divided by the number of Ordinary Shares represented by one ADS on each such Trading Day) over the 10 consecutive Trading Day period ending on, and including, the Trading Day immediately preceding the date of announcement of such
issuance.

 Any increase made under this Section 7.05(b) will be made successively whenever any such rights, options or warrants
are issued and shall become effective immediately after the Open of Business on the Ex-Dividend Date for such issuance. To the extent that Ordinary Shares or ADSs are not delivered after the expiration of such rights, options or warrants, the
Exchange Rate shall be readjusted to the Exchange Rate that would then be in effect had the increase with respect to the issuance of such rights, options or warrants been made on the basis of delivery of only the number of Ordinary Shares or ADSs
actually delivered. If such rights, options or warrants are not so issued, the Exchange Rate shall be readjusted to be the Exchange Rate that would then be in effect if the Ex-Dividend Date for such issuance had not occurred. 

For purposes of this Section 7.05(b) and for purposes of Section 7.01(c)(i), in determining whether any rights, options or
warrants entitle holders of Ordinary Shares or ADSs to subscribe for or purchase Ordinary Shares, at a price per Ordinary Share less than such average of the Last Reported Sale Prices for the ADSs (divided by the number of Ordinary Shares
represented by one ADS on each such Trading Day), or to subscribe for or purchase ADSs, at a price per ADS less than such average of the Last Reported Sale Prices for the ADSs, in each case, over the 10 consecutive Trading Day period ending on, and
including, the Trading Day immediately preceding the date of announcement for an issuance, and in determining the aggregate offering price of such Ordinary Shares or ADSs, as 

  
 55 

 
the case may be, there shall be taken into account any consideration received by the Guarantor for such rights, options or warrants and any amount payable on exercise or exchange thereof, the
value of such consideration, if other than cash, to be determined by the Guarantor’s Board of Directors. 

(c) Spin-Offs and Other Distributed Property. 

(i) If the Guarantor distributes shares of the Capital Stock of the Guarantor, evidences of its indebtedness, other
assets or property of the Guarantor or rights, options or warrants to acquire the Guarantor’s Capital Stock or other securities of the Guarantor (the “Distributed Property”) to all or substantially all holders of the Ordinary
Shares, excluding: 
 (A) dividends, distributions, rights, options or warrants as to which an adjustment was
effected pursuant to Section 7.05(a) hereof or Section 7.05(b) hereof; 
 (B) dividends or
distributions paid exclusively in cash as to which an adjustment was effected pursuant to Section 7.05(d) hereof; 
 (C) any dividends and distributions in connection with a reclassification, change, consolidation, merger, conveyance, transfer, sale, lease or other disposition resulting in the change in the Exchange
Consideration as described in Section 7.07; 
 (D) except as otherwise described above and below under this
Section 7.05, rights issued pursuant to a stockholder rights plan adopted by the Guarantor; or 
 (E)
Spin-Offs as to which the provisions of Section 7.05(c)(ii) hereof shall apply, 
 then the Exchange Rate will be increased based on the
following formula: 
  

									
		 	ER1 =	 	ER0 ×	 	 SP0
	 	
	 	 	 	SP0 – FMV	 	

  

					
	where:	  		  	
			
	ER0	  	=	  	the Exchange Rate in effect immediately prior to the Open of Business on the Ex-Dividend Date for such distribution;
			
	ER1	  	=	  	the Exchange Rate in effect immediately after the Open of Business on such Ex-Dividend Date;
			
	SP0	  	=	  	the average of the Last Reported Sale Prices of the ADSs (divided by the number of Ordinary Shares represented by one ADS on each such Trading Day) over the 10 consecutive
Trading Day period ending on, and including, the Trading Day immediately preceding the Ex-Dividend Date for such distribution; and
			
	FMV	  	=	  	the fair market value (as determined by the Guarantor’s Board of Directors) of the Distributed Property distributed with respect to each outstanding Ordinary Share on the
Ex-Dividend Date for such distribution.

 If “FMV” (as defined above) is equal to or greater than the “SP0” (as defined above), in lieu of the foregoing increase, each Holder
will receive, in respect of each $1,000 principal amount of Notes it holds, at the same time and upon the same terms as holders of the ADSs, the amount and kind of the Distributed Property that such Holder would have received if such Holder had
owned a number of ADSs equal to the Exchange Rate in effect on the Ex-Dividend Date for the distribution. 

  
 56 

 Any increase in the Exchange Rate made under this Section 7.05(c)(i) will become
effective immediately after the Open of Business on the Ex-Dividend Date for such distribution. If such distribution is not so paid or made, the Exchange Rate shall be readjusted to be the Exchange Rate that would then be in effect if such dividend
or distribution had not been declared. 
 (ii) With respect to an adjustment pursuant to this
Section 7.05(c) where there has been a payment of a dividend or other distribution on the Ordinary Shares of any class or series, or similar equity interest, of or relating to a Subsidiary or other business unit of the Guarantor, and such
Capital Stock or similar equity interest is listed or quoted (or will be listed or quoted upon the consummation of such dividend or other distribution) on a U.S. national securities exchange or a reasonably comparable non-U.S. equivalent (a
“Spin-Off”), the Exchange Rate will be increased based on the following formula: 
  

									
		 	ER1 =	 	ER0 ×	 	 FMV0 + MP0
	 	
	 	 	 	MP0	 	

  

					
	where:	  		  	
			
	ER0	  	=	  	the Exchange Rate in effect immediately prior to the Open of Business on the Ex-Dividend Date for the Spin-Off;
			
	ER1	  	=	  	the Exchange Rate in effect immediately after the Open of Business on the Ex-Dividend Date for the Spin-Off;
			
	FMV0	  	=	  	the average of the Last Reported Sale Prices of the Capital Stock or similar equity interest distributed to holders of the Ordinary Shares applicable to one Ordinary Share over the
first 10 consecutive Trading Day period after, and including, the effective date of the Spin-Off (the “Valuation Period”); and
			
	MP0	  	=	  	the average of the Last Reported Sale Prices of the ADSs (divided by the number of Ordinary Shares represented by one ADS on each such Trading Day) over the Valuation
Period.

 If a Holder exchanges a Note, Cash Settlement or Combination Settlement applies to such Note, and the first VWAP Trading
Day of the Observation Period applicable to such Note occurs after the first Trading Day of the Valuation Period for a Spin-Off, but on or before the last Trading Day of the Valuation Period for such Spin-Off, the reference in the above definition
of “FMV” to “10” shall be deemed replaced with such lesser number of Trading Days as have elapsed from, and including, the effective date of such Spin-Off to, but excluding, the first VWAP Trading Day of such Observation Period.
If a Holder exchanges a Note, Cash Settlement or Combination Settlement applies to such Note, and one or more VWAP Trading Days of the Observation Period applicable to such Note occurs on or after the Ex-Dividend Date for a Spin-Off, but on or prior
to the first Trading Day of the Valuation Period for such Spin-Off, such Observation Period will be suspended on the first such Trading Day and will resume immediately after the first Trading Day of the Valuation Period for such Spin-Off, and the
reference in the above definition of “FMV” to “10” shall be deemed replaced with a reference to “one” (1). 
 For purposes of this Section 7.05(c)(ii), the Last Reported Sale Price of any Capital Stock or similar equity interest shall be calculated in a manner analogous to that used to calculate the Last
Reported Sale Price of the ADSs in the definition of “Last Reported Sale Price” set forth in Section 1.01 hereof. 
 For purposes of Section 7.05(a) hereof, Section 7.05(b) hereof and this Section 7.05(c), if any dividend or distribution to which this Section 7.05(c) applies includes one or both of:

 (A) a dividend or distribution of Ordinary Shares to which Section 7.05(a) hereof also applies (the
“Clause A Distribution”); or 

  
 57 

 (B) a dividend or distribution of rights, options or warrants to which
Section 7.05(b) hereof also applies (the “Clause B Distribution”), 
 then (i) such dividend or distribution, other
than the Clause A Distribution and the Clause B Distribution, shall be deemed to be a dividend or distribution to which this Section 7.05(c) applies (the “Clause C Distribution”) and any Exchange Rate adjustment required to be
made under this Section 7.05(c) with respect to such Clause C Distribution shall be made, (ii) the Clause B Distribution, if any, shall be deemed to immediately follow the Clause C Distribution and any Exchange Rate adjustment required by
Section 7.05(b) hereof with respect thereto shall then be made, except that, if determined by the Guarantor, (A) the “Ex-Dividend Date” of the Clause B Distribution and the Clause A Distribution, if any, shall be deemed to be the
Ex-Dividend Date of the Clause C Distribution and (B) any Ordinary Shares (or any Ordinary Shares represented by ADSs) included in the Clause A Distribution or the Clause B Distribution shall not be deemed to be to be “outstanding
immediately prior to the Open of Business on such Ex-Dividend Date” within the meaning of Section 7.05(b) hereof, and (iii) the Clause A Distribution, if any, shall be deemed to immediately follow the Clause C Distribution or the
Clause B Distribution, as the case may be, except that, if determined by the Guarantor, (A) the “Ex-Dividend Date” of the Clause A Distribution and the Clause B Distribution, if any, shall be deemed to be the Ex-Dividend Date of the
Clause C Distribution, and any Ordinary Shares included in the Clause A distribution shall not be deemed to be “outstanding immediately prior to the Open of Business on such Ex-Dividend Date or such effective date” within the meaning of
Section 7.05(a) hereof. 
 (d) Cash Dividends or Distributions. If any cash dividend or distribution
is made to all or substantially all holders of the Ordinary Shares, the Exchange Rate will be adjusted based on the following formula: 
  

									
		 	ER1 =	 	ER0 ×	 	 SP0
	 	
	 	 	 	SP0 – C	 	

  

					
	where:	  		  	
			
	ER0	  	=	  	the Exchange Rate in effect immediately prior to the Open of Business on the Ex-Dividend Date for such dividend or distribution;
			
	ER1	  	=	  	the Exchange Rate in effect immediately after the Open of Business on the Ex-Dividend Date for such dividend or distribution;
			
	SP0	  	=	  	the Last Reported Sale Price of the ADSs (divided by the number of Ordinary Shares represented by one ADS on such Trading Day) on the Trading Day immediately preceding the
Ex-Dividend Date for such dividend or distribution; and
			
	C	  	=	  	the amount in cash per Ordinary Share that the Guarantor distributes to holders of the Ordinary Shares.

 If “C” (as defined above) is equal to or greater than “SP0” (as defined above), in lieu of the foregoing increase, each Holder
shall receive, for each $1,000 principal amount of Notes it holds, at the same time and upon the same terms as holders of the ADSs, the amount of cash that such Holder would have received if such Holder had owned a number of ADSs equal to the
Exchange Rate on the Ex-Dividend Date for such cash dividend or distribution. Any such increase shall become effective immediately after the Open of Business on the Ex-Dividend Date for such dividend or distribution. If such dividend or distribution
is not so paid, the Exchange Rate shall be decreased to be the Exchange Rate that would then be in effect if such dividend or distribution had not been declared. 

(e) Tender Offers or Exchange Offers. If the Guarantor or any of its Subsidiaries makes a payment in respect of a
tender offer or exchange offer for the Ordinary Shares or the ADSs (that is subject to the tender offer rules of the Exchange Act that are then applicable), other than odd lot tender offers, to the extent that the cash and value of any other
consideration included in the payment per Ordinary Share or ADS exceeds the Last Reported Sale Price of the ADSs (divided by, in the case of Ordinary Shares, the 

  
 58 

 
number of Ordinary Shares represented by one ADS on such Trading Day) on the Trading Day next succeeding the last date on which tenders or exchanges may be made pursuant to such tender offer or
exchange offer (the “Expiration Date”), the Exchange Rate will be increased based on the following formula: 
  

									
		 	ER1 =	 	ER0 ×	 	 AC + (SP1 × OS1)
	 	
	 	 	 	OS0 ×
SP1	 	

  

					
	 where:
	  		  	
			
	ER0	  	=	  	the Exchange Rate in effect immediately prior to the Close of Business on the Expiration Date;
			
	ER1	  	=	  	the Exchange Rate in effect immediately after the Close of Business on the Expiration Date;
			
	AC	  	=	  	the aggregate value, on the Expiration Date, of all cash and any other consideration (as determined by the Guarantor’s Board of Directors) paid or payable for Ordinary Shares
or ADSs purchased in such tender offer or exchange offer;
			
	OS0	  	=	  	the number of Ordinary Shares outstanding immediately prior to the Close of Business on the Expiration Date (prior to giving effect to the purchase of all Ordinary Shares or ADSs
accepted for purchase or exchange in such tender offer or exchange offer);
			
	OS1	  	=	  	the number of Ordinary Shares outstanding immediately after the Close of Business on the Expiration Date (after giving effect to the purchase of all Ordinary Shares or ADSs accepted
for purchase or exchange in such tender offer or exchange offer); and
			
	SP1	  	=	  	the average of the Last Reported Sale Prices of the ADSs (divided by the number of Ordinary Shares represented by one ADS on each such Trading Day) over the 10 consecutive
Trading Day period commencing on, and including, the Trading Day next succeeding the Expiration Date (the “Averaging Period”).

 If a Holder exchanges a Note, Cash Settlement or Combination Settlement applies to such Note, and the
first VWAP Trading Day of the Observation Period applicable to such Note occurs after the first Trading Day of the Averaging Period for any tender offer or exchange offer, but on or before the last Trading Day of the Averaging Period for such tender
offer or exchange offer, the reference in the above definition of “SP1” to “10” shall be deemed replaced with such lesser number of Trading Days as have elapsed from, and including, the first Trading Day of the Averaging Period for such tender or exchange
offer to, but excluding, the first VWAP Trading Day of such Observation Period. If a Holder exchanges a Note, Cash Settlement or Combination Settlement applies to such Note, and one or more VWAP Trading Days of the Observation Period for such Note
occurs on or after the Expiration Date for any tender offer or exchange offer, but on or prior to the first Trading Day in the Averaging Period for a tender offer or exchange offer, such Observation Period will be suspended on the first such Trading
Day and will resume immediately after the first Trading Day of the Averaging Period for such tender or exchange offer and the reference in the above definition of “SP” to “10” shall be deemed replaced with a reference to
“one” (1). 
 (f) Special Provisions for ADS Adjustments. Without duplication of any other
adjustment pursuant to this Section 7.05, in the event of (i) any subdivision or split of the outstanding ADSs, (ii) any distribution of additional ADSs to holders of the ADSs, or (iii) any combination of the outstanding ADSs
into a smaller number of ADSs, the Exchange Rate shall be adjusted as of the Open of Business on the effective date for any such subdivision or combination or as of the Open of Business on the Ex-Dividend Date for any such distribution, as the case
may be, to be equal to the number of ADSs that a holder of a number of ADSs equal to the Exchange Rate immediately prior to the effective date of any such subdivision or combination or the Ex-Dividend Date for such distribution, as the case may be,
would hold immediately following such subdivision, distribution or combination. 

  
 59 

 (g) Special Provisions for Combination Settlement of Certain
Exchanges. Notwithstanding anything to the contrary herein: If a Holder exchanges a Note and (i) Combination Settlement applies to such Note, (ii) the Ex-Dividend Date, effective date or Expiration Date for any event that requires an
adjustment to the Exchange Rate under any of clauses (a) through (e) of this Section 7.05 occurs on or prior to the last VWAP Trading Day of the related Observation Period; and (iii) the Daily Settlement Amount for any VWAP
Trading Day in such Observation Period that occurs on or prior to such Ex-Dividend Date, effective date or Expiration Date (x) includes ADSs that do not entitle their holder to participate in such event; and (y) is calculated based on an
Exchange Rate that is not adjusted on account of such event, then, on account of such exchange, the Issuer or the Guarantor will, on such Ex-Dividend Date, effective date or Expiration Date, as the case may be, treat such Holder, as a result of
having exchanged such Notes, as though it were the holder of record of a number of ADSs equal to the total number of ADSs that (A) are deliverable as part of the Daily Settlement Amount (I) for a VWAP Trading Day in such Observation Period
that occurs on or prior to such Ex-Dividend Date, effective date or Expiration Date; and (II) is calculated based on an Exchange Rate that is not adjusted for such event; and (B) but for this provision, would not entitle such Holder to
participate in such event. 
 (h) Rights Plan. To the extent that the Guarantor has a rights plan
applicable to the ADSs in effect upon exchange of any Notes, if Physical Settlement applies to such a Note, on the applicable Exchange Date, and if Combination Settlement applies to such a Note, on any VWAP Trading Day in the Observation Period
applicable to such Note, the exchanging Holder will receive, in addition to any ADSs received in connection with, if Physical Settlement applies, the Exchange Obligation calculated on such Exchange Date, and if Combination Settlement applies, the
Daily Settlement Amount for such VWAP Trading Day, the rights under such rights plan, unless prior to such Exchange Date or VWAP Trading Day, as the case may be, the rights have separated from the ADSs, in which case, and only in such case, the
Exchange Rate will be adjusted at the time of separation as if the Guarantor distributed, to all holders of the Ordinary Shares, the Distributed Property as described in clause (c) of this Section 7.05, subject to readjustment in the event
of the expiration, termination or redemption of such rights. 
 (i) Other Adjustments. Whenever a
provision of this Indenture requires the calculation of the Last Reported Sale Prices, the Daily VWAPs, the Daily Exchange Values, the Daily Settlement Amounts or any functions thereof over a span of multiple days (including, without limitation,
during an Observation Period and, if applicable, during the 10 Trading Day period used to determine the ADS Price for purposes of a Make-Whole Fundamental Change), the Issuer will make appropriate adjustments (to the extent no corresponding
adjustment is otherwise made pursuant to the provisions in Section 7.05) to each to account for any event requiring an adjustment to the Exchange Rate where the Ex-Dividend Date, effective date or Expiration Date of the event occurs at any time
during the period when the Last Reported Sale Prices, the Daily VWAPs, the Daily Exchange Values, the Daily Settlement Amounts or any functions thereof are to be calculated. 

(j) Successive Adjustments. After an adjustment to the Exchange Rate under this Article 7, any subsequent event
requiring an adjustment under this Article 7 will cause an adjustment to the Exchange Rate as so adjusted, without duplication. 
 (k) Limitations on Adjustments. 
 (i) Except as stated in
this Article 7, the Issuer will not adjust the Exchange Rate for the issuance of Ordinary Shares or ADSs or any securities exchangeable into or exchangeable for Ordinary Shares or ADSs or the right to purchase Ordinary Shares or ADSs or such
exchangeable or exchangeable securities. 

  
 60 

 (ii) In addition, notwithstanding anything to the contrary in this
Section 7.05, the Issuer will not be required to adjust the Exchange Rate: 
 (A) upon the issuance of:

 (1) any Ordinary Shares or ADSs pursuant to any present or future plan providing for the reinvestment of
dividends or interest payable on the Guarantor’s securities and the investment of additional optional amounts in Ordinary Shares or ADSs under any plan; 
 (2) any Ordinary Shares or ADSs or options or rights to purchase Ordinary Shares or ADSs pursuant to any present or future employee, director or consultant benefit plan or program of, or assumed by, the
Guarantor or any of its Subsidiaries; or 
 (3) any Ordinary Shares or ADSs pursuant to any option, warrant,
right or exercisable, convertible or exchangeable security not described in clause (2) above and outstanding as of the Issue Date; 
 (B) for a change solely in the par value of the Ordinary Shares; or 
 (C) for accrued and unpaid interest, and Additional Interest on the Notes, if any. 
 (l) Notwithstanding anything to the contrary in this Section 7.05, except on and after the first VWAP Trading Day of the Observation Period with respect to a Note and on or prior to the last VWAP
Trading Day of such Observation Period, the Issuer shall not be required to adjust the Exchange Rate unless such adjustment would require an increase or decrease of at least one percent; provided, however, that any such minor
adjustments that are not required to be made will be carried forward and taken into account in any subsequent adjustment, and provided, further, that any such adjustment of less than one percent that has not been made shall be
made (i) on the Make-Whole Fundamental Change Effective Date for any Make-Whole Fundamental Change, and (ii)(A) in the case of any Note to which Physical Settlement applies, upon the Exchange Date, and (B) in the case of any Note to
which Cash Settlement or Combination Settlement applies, on the first VWAP Trading Day of the applicable Observation Period. In addition, the Issuer shall not account for such deferrals when determining whether any of the conditions to exchange have
been satisfied or what number of the ADSs a Holder would have held on a given day had it exchanged the Notes. 

(m) For purposes of this Section 7.05, subject to Section 7.05(c) hereof, the number of Ordinary Shares or ADSs
outstanding at any time will include Ordinary Shares or ADSs issuable in respect of scrip certificates issued in lieu of fractions of Ordinary Shares or ADSs, but, so long as the Guarantor does not pay any dividend or make any distribution on
Ordinary Shares or ADSs held in the treasury of the Guarantor, will not include Ordinary Shares or ADSs held in the treasury of the Guarantor. 
 (n) Voluntary Adjustments. 
 (i) Incentive
Increases. To the extent permitted by applicable law and subject to the applicable rules of The NASDAQ Global Market (or any other securities exchange on which the Guarantor’s securities are then listed), the Issuer may increase the
Exchange Rate by any amount for a period of at least 20 Business Days if the Board of Directors determined that such increase would be in the Issuer’s best interest. 

(ii) Tax-Related Increases. The Issuer may also (but is not required to) increase the Exchange Rate if the Board
of Directors determines that such increase would avoid or diminish income tax to holders of the Ordinary Shares or ADSs or rights to purchase the Ordinary Shares or ADS in connection with a dividend or distribution of Ordinary Shares or ADSs (or
rights to acquire Ordinary Shares or ADSs) or similar event. 

  
 61 

 (o) Notices. 

(i) Notice to Holders Prior to Certain Actions and Events. The Issuer shall deliver notices of the events
specified below at the times specified below and containing the information specified below unless, in each case, (i) pursuant to this Indenture, the Issuer is already required to deliver notice of such event containing at least the information
specified below at an earlier time, or, (ii) neither the Issuer, at the time it is required to deliver a notice, nor the Guarantor has knowledge of all of the information required to be included in such notice, in which case, the Issuer shall
(A) deliver notice at such time containing only the information that it or the Guarantor has knowledge of at such time (if it or the Guarantor has knowledge of any such information at such time), and (B) promptly upon it or the Guarantor
obtaining knowledge of any such information not already included in a notice delivered by the Issuer, deliver notice to each Holder containing such information. In each case, the failure by the Issuer to give such notice, or any defect therein,
shall not affect the legality or validity of such event. 
 (ii) Issuances, Distributions, and Dividends and
Distributions. If the Guarantor (A) announces any issuance of any rights, options or warrants that would require an adjustment in the Exchange Rate pursuant to Section 7.05(b) hereof; (B) authorizes any distribution that would
require an adjustment in the Exchange Rate pursuant to Section 7.05(c) hereof (including any separation of rights from the ADSs described in Section 7.05(h) hereof); or (C) announces any dividend or distribution that would require an
adjustment in the Exchange Rate pursuant to Section 7.05(d) hereof, then the Issuer shall deliver to the Holders, as promptly as possible, but in any event at least 35 Scheduled Trading Days prior to the applicable Ex-Dividend Date, notice
describing such issuance, distribution, dividend or distribution, as the case may be, and stating the expected Ex-Dividend Date and record date for such issuance, distribution, dividend or distribution, as the case may be. In addition, the Issuer
shall deliver to the Holders notice if any of the consideration included in such issuance, distribution, dividend or distribution, or the Ex-Dividend Date or record date of such issuance, distribution, dividend or distribution, as the case may be,
changes. 
 (iii) Tender and Exchange Offers. If the Guarantor announces any tender offer or exchange
offer that could require an adjustment in the Exchange Rate pursuant to Section 7.05(e) hereof, the Issuer shall deliver to the Holders on the day it announces such tender offer or exchange offer, and, if the Guarantor is required to file with
the Commission a Schedule TO in connection with such tender offer or exchange offer, an additional notice (i) when the Guarantor first files such Schedule TO, which notice shall include the address at which such Schedule TO is available on
EDGAR (or any successor thereto), and, (ii) whenever the Guarantor files an amendment to such Schedule TO, which notice shall include the address at which such amendment is available on EDGAR (or any successor thereto). 

(iv) Voluntary Increases. If the Issuer increases the Exchange Rate pursuant to Section 7.05(n), the Issuer
shall deliver notice to the Holders at least 15 calendar days prior to the date on which such increase will become effective, which notice shall state the date on which such increased will become effective and the amount by which the Exchange Rate
will be increased. 
 (v) Dissolutions, Liquidations and Winding-Ups. If there is a voluntary or
involuntary dissolution, liquidation or winding-up of the Issuer or the Guarantor, the Issuer shall deliver notice to the Holders at promptly as possible, but in any event at least 35 Scheduled Trading Days prior to the earlier of (i) the date
on which such dissolution, liquidation or winding-up, as the case may be, is expected to become effective or occur, and (ii) the date or dates as of which it is expected that holders of Ordinary Shares and/or ADSs, as the case may be, of record
shall be entitled to exchange their Ordinary Shares and/or ADSs, as the case may be, for securities or other property deliverable upon such dissolution, liquidation or winding-up, as the case may be, which notice shall state the expected effective
date and record date for such event, as applicable, and the amount and kind of property that a holder of one Ordinary Share and/or one ADS, as the case may be, is expected to be entitled, or may elect, to receive in such event. The Issuer shall

  
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deliver an additional notice to holders, as promptly as practicable, whenever the expected effective date or record date, as applicable, or the amount and kind of property that a holder of one
Ordinary Share and/or one ADS, as the case may be, is expect to be entitled to receive in such event, changes. 

(vi) Notices After Certain Actions and Events. Whenever an adjustment to the Exchange Rate becomes effective
pursuant to this Section 7.05, the Issuer will (i) file with the Trustee an Officer’s Certificate stating that such adjustment has become effective, the Exchange Rate, and the manner in which the adjustment was computed and
(ii) deliver notice to the Holders stating that such adjustment has become effective and the Exchange Rate or exchange privilege as adjusted. Failure to give any such notice, or any defect therein, shall not affect the validity of any such
adjustment 
 (p) If the Ordinary Shares cease to be represented by American Depositary Shares issued under a
depositary receipt program sponsored by the Guarantor, all references in this Indenture to the ADSs shall be deemed to have been replaced by a reference to the number of Ordinary Shares represented by the ADSs on the last day on which the ADSs
represented the Ordinary Shares (as adjusted pursuant to this Section 7.05 for any other property represented by the ADSs) and as if the Ordinary Shares and/or other property had been distributed to holders of the ADSs on that day. 

Section 7.06 Adjustments to Exchange Rate upon Exchange In Connection With a Make-Whole Fundamental Change. 

(a) General. If a Fundamental Change (as defined herein and determined after giving effect to any exceptions to or
exclusions from such definition, but without regard to the proviso in clause (2) of the definition of Fundamental Change, a “Make-Whole Fundamental Change”) occurs on or prior to January 15, 2017 and a Holder elects
to exchange its Notes “in connection with” such Make-Whole Fundamental Change, the Issuer will, in the circumstances described in this Section 7.06, increase the Exchange Rate applicable to the Notes so surrendered for exchange by a
number of additional ADSs (the “Additional Shares”) as set forth in this Section 7.06. For purposes of this Section 7.06, a exchange of Notes will be deemed to be “in connection with” a Make-Whole Fundamental
Change if the Exchange Notice for such Notes is received by the Exchange Agent during the period from, and including, the effective date of such Make-Whole Fundamental Change (the “Make-Whole Fundamental Change Effective Date”) up
to, and including, the Close of Business on the Business Day immediately preceding the Fundamental Change Repurchase Date for such Make-Whole Fundamental Change; provided, however, that in the event of a Make-Whole Fundamental Change that
would have been a Fundamental Change but for the proviso in clause (2) of the definition of Fundamental Change, a exchange of Notes will be deemed to be “in connection with” a Make-Whole Fundamental Change if the Exchange
Notice for such Notes is received by the Exchange Agent during the period from, and including, the Make-Whole Fundamental Change Effective Date up to, and including, the 35th Business Day immediately following such Make-Whole Fundamental Change
Effective Date. 
 (b) Determination of Additional Shares. The number of Additional Shares, if any, by
which the Exchange Rate will be increased if a Holder exchanges a Note “in connection with” a Make-Whole Fundamental Change will be determined by reference to the table below and will be based on the related Make-Whole Fundamental Change
Effective Date and the ADS Price for such Make-Whole Fundamental Change. 
 (c) Adjustment of ADS Prices and
Additional Shares. The ADS Prices set forth in the column headings of the table below will be adjusted as of any date on which the Exchange Rate of the Notes is otherwise required to be adjusted pursuant to Section 7.05 hereof. The adjusted
ADS Prices in the table below will equal the ADS Prices in effect immediately prior to such adjustment, multiplied by a fraction, the numerator of which is the Exchange Rate in effect immediately prior to the adjustment giving rise to the adjustment
to the ADS Price and the denominator of which is the Exchange Rate in effect immediately after such adjustment. The numbers of Additional Shares set forth in the table below will be adjusted in the same manner, at the same time and on account of the
same events for which the Exchange Rate must be adjusted as set forth in Section 7.05 hereof. 

  
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 (d) Additional Shares Table. The following table sets forth the
number of Additional Shares by which the Exchange Rate will be increased for a Make-Whole Fundamental Change having the ADS Price and the Make-Whole Fundamental Change Effective Date set forth below: 

 

																																																	
	 	 	ADS price	 
	 	 	$7.05	 	 	$8.00	 	 	$9.00	 	 	$10.00	 	 	$12.50	 	 	$15.00	 	 	$17.50	 	 	$20.00	 	 	$25.00	 	 	$30.00	 	 	$40.00	 	 	$60.00	 
	 January 9, 2012
	 	 	28.3687	  	 	 	28.3687	  	 	 	27.6764	  	 	 	22.8784	  	 	 	15.1514	  	 	 	10.7291	  	 	 	7.9634	  	 	 	6.1159	  	 	 	3.8673	  	 	 	2.5930	  	 	 	1.2661	  	 	 	0.2941	  
	 January 15, 2013
	 	 	28.3687	  	 	 	28.3687	  	 	 	26.2698	  	 	 	21.3754	  	 	 	13.6814	  	 	 	9.4344	  	 	 	6.8636	  	 	 	5.1933	  	 	 	3.2212	  	 	 	2.1352	  	 	 	1.0251	  	 	 	0.2208	  
	 January 15, 2014
	 	 	28.3687	  	 	 	28.3687	  	 	 	24.1451	  	 	 	19.1827	  	 	 	11.6534	  	 	 	7.7199	  	 	 	5.4567	  	 	 	4.0486	  	 	 	2.4592	  	 	 	1.6164	  	 	 	0.7675	  	 	 	0.1485	  
	 January 15, 2015
	 	 	28.3687	  	 	 	27.8264	  	 	 	20.7221	  	 	 	15.7826	  	 	 	8.7380	  	 	 	5.4098	  	 	 	3.6663	  	 	 	2.6618	  	 	 	1.6042	  	 	 	1.0640	  	 	 	0.5097	  	 	 	0.0824	  
	 January 15, 2016
	 	 	28.3687	  	 	 	22.6551	  	 	 	15.2684	  	 	 	10.5019	  	 	 	4.6401	  	 	 	2.5059	  	 	 	1.6254	  	 	 	1.1943	  	 	 	0.7687	  	 	 	0.5355	  	 	 	0.2628	  	 	 	0.0241	  
	 January 15, 2017
	 	 	28.3687	  	 	 	11.5248	  	 	 	0.0000	  	 	 	0.0000	  	 	 	0.0000	  	 	 	0.0000	  	 	 	0.0000	  	 	 	0.0000	  	 	 	0.0000	  	 	 	0.0000	  	 	 	0.0000	  	 	 	0.0000	  

 (e) Use of Additional Shares Table. If the exact ADS Price and/or Make-Whole
Fundamental Change Effective Date for a Make-Whole Fundamental Change are not set forth in the table above, then: 
 (i) if the ADS Price is between two ADS Prices in the table or the Make-Whole Fundamental Change Effective Date is between two Make-Whole Fundamental Change Effective Dates in the table, the number of
Additional Shares will be determined by a straight-line interpolation between the numbers of Additional Shares set forth in the table for the higher and lower ADS Prices and the earlier and later Make-Whole Fundamental Change Effective Dates, as
applicable, based on a 365-day year; 
 (ii) if the ADS Price is greater than $60.00 per ADS, subject to
adjustment in the same manner as the ADS Prices set forth in the column headings of the table above, no Additional Shares will be added to the Exchange Rate; and 

(iii) if the ADS Price is less than $7.05 per ADS, subject to adjustment in the same manner as the ADS Prices set forth
in the column headings of the table above, no Additional Shares will be added to the Exchange Rate. 
 Notwithstanding the foregoing, in no
event will the Exchange Rate, as increased pursuant to this Section 7.06 by the number of Additional Shares, exceed 141.8439 ADSs per $1,000 principal amount of Notes, subject to adjustments in the same manner, at the same time and on account
of the same events for which the Exchange Rate is required to be adjusted as set forth in Section 7.05 hereof. 
 (f) Settlement of Exchanges “In Connection With” a Make-Whole Fundamental Change. If a Holder exchanges a Note “in connection with” a Make-Whole Fundamental Change, the Issuer
will settle the exchange in accordance with Section 7.03 hereof (after giving effect to any increase in the Exchange Rate required by this Section 7.06); provided, however, that notwithstanding anything to the contrary in
Section 7.03 hereof, if a Holder exchanges a Note “in connection with” a Make-Whole Fundamental Change and such Make-Whole Fundamental Change is a Cash Merger, the Issuer will satisfy its Exchange Obligation with respect to such Note
by paying to the exchanging Holder, on the third Business Day immediately following the applicable Exchange Date, in lieu of any cash, ADSs or combination of cash and ADSs that it would otherwise be obligated to pay or deliver, as the case may be,
to such Holder pursuant to Section 7.03, an amount of cash equal to the product of (i) the Exchange Rate in effect on the applicable Exchange Date (including any adjustment that the Issuer is required to make pursuant to this
Section 7.06) and (ii) the ADS Price for such Make-Whole Fundamental Change. For any Make-Whole Fundamental Change, the Issuer shall notify Holders on the related Make-Whole Fundamental Change Effective Date and issue a press release
announcing such Make-Whole Fundamental Change Effective Date no later than five Business Days after such Make-Whole Fundamental Change Effective Date. 

  
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 Section 7.07 Effect of Recapitalization, Reclassification, Consolidation, Merger or
Sale. 
 (a) In General. If any of the following events occur: 

(i) any recapitalization, reclassification or change of the Ordinary Shares (other than changes resulting from a
subdivision or combination or change in par value); 
 (ii) any consolidation, merger, scheme of arrangement or
offer or combination involving the Guarantor; 
 (iii) any sale, lease or other transfer to a third party of the
consolidated assets of the Guarantor and its Subsidiaries substantially as an entirety; or 
 (iv) any statutory
share exchange; 
 and, in each case, as a result of such event, the ADSs would be exchanged into, or exchanged for, stock, other securities,
other property or assets (including cash or any combination thereof) (each such event, a “Merger Event,” such stock, other securities, other property or assets (including cash or any combination thereof), “Reference
Property,” and the amount and kind of Reference Property that a holder of one ADS is entitled to receive in such Merger Event, or if such Merger Event causes the ADSs to be exchanged into, or exchange for, the right to receive more than a
single type of consideration (determined based in part upon any form of shareholder election), the weighted per-ADS average of the types and amounts of consideration received by the holders of ADSs that affirmatively make such an election, a
“Unit of Reference Property”), then at and after the effective time of Merger Event, the right to exchange each $1,000 principal amount of Notes based on a number of ADSs equal to the Exchange Rate will be changed into the right to
exchange such principal amount of Notes based on a number of Units of Reference Property equal to the Exchange Rate. In particular, prior to the effective date of the Merger Event, the Issuer or the successor or purchasing Person, as the case may
be, will execute with the Trustee a supplemental indenture pursuant to Section 14.02 hereof, that will not adversely affect the rights of any Holder and that will provide that, at and after the effective time of the Merger Event: 

(A) the Issuer will continue to have the right to choose the Settlement Method applicable to any exchanged Notes to the
extent otherwise provided in Section 7.03 hereof; 
 (B) any amount of cash that the Issuer would otherwise
be required to pay pursuant to Sections 7.03, 7.05 and 7.06 as part of the Exchange Obligation with respect to a Note will continue to be payable in cash; 
 (C) any number of ADSs that the Issuer would otherwise be required to deliver pursuant to Sections 7.03, 7.05, 7.06 and 7.09 hereof as part the Exchange Obligation with respect to a Note will instead be
deliverable in Units of Reference Property; 
 (D) the Daily VWAP and the Last Reported Sale Price will be
calculated based on the value of a Unit of Reference Property; and 
 (E) the Exchange Rate shall be subject to
adjustments that the Board of Directors determines are as nearly equivalent as possible to the adjustments provided for in Article 7 hereof. 
 (b) If, for any Merger Event, the Reference Property includes shares of stock, securities or other property or assets (including cash or any combination thereof) of a Person other than the successor or

  
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purchasing corporation, as the case may be, in such Merger Event, then such supplemental indenture shall also be executed by such other Person and shall contain such additional provisions to
protect the interests of the Holders as the Board of Directors shall reasonably consider necessary by reason of the foregoing. 
 (c) Notices. If the Issuer, the Guarantor or any successor or purchasing Person or other Person executes a supplemental indenture pursuant to Section 7.07(a) hereof and Article 10 hereof, as
applicable, then the Issuer or such successor or purchasing Person or other Person, as applicable, shall promptly file with the Trustee an Officer’s Certificate briefly stating the reasons therefore, the kind or amount of cash, securities or
property or assets that will comprise a Unit of Reference Property after the applicable Merger Event, any adjustment to be made with respect thereto and that all relevant conditions precedent have been complied with, and shall promptly deliver
notice thereof to all Holders. If, at the time such a supplemental indenture is executed, the Issuer cannot calculate the composition of a Unit of Reference Property because it is subject to a shareholder election, the Issuer may deliver notice of
the kind or amount of cash, securities or property or assets that will comprise a Unit of Reference Property after the Merger Event as promptly as practicable after it is able to make such calculation. Failure to deliver such notice shall not affect
the legality or validity of such supplemental indenture. 
 (d) Neither the Issuer nor the Guarantor shall
become a party to any Merger Event unless its terms are consistent with the foregoing. 
 (e) The above
provisions of this Section 7.07 shall similarly apply to successive Merger Events. 
 Section 7.08 No
Responsibility of Trustee. The Trustee and the Exchange Agent will not have any duty or responsibility to any Holder to determine whether any facts exist that require an adjustment of the Exchange Rate, or with respect to the nature or extent or
calculation of any such adjustment when made, or with respect to the method employed in making the same. Neither the Trustee nor the Exchange Agent will be responsible for any failure of the Issuer to deliver any amount of cash and/or number of
ADSs, as applicable, upon the surrender of any Notes for the purpose of exchange or to comply with any of the duties, responsibilities or covenants of the Issuer contained in this Article 7. Without limiting the generality of the foregoing, neither
the Trustee nor the Exchange Agent will be under any responsibility to determine the correctness of any provisions contained in any supplemental indenture entered into pursuant to Section 7.07 hereof, including with respect to the calculation
of the amount of cash, the number of Units of Reference Property or the combination of cash and Units of Reference Property receivable by Holders upon the exchange of their Notes after any Merger Event, and each, subject to the provisions of Article
11 in the case of the Trustee, may accept as conclusive evidence of the correctness of any such provisions, and will be protected in relying upon, the Officer’s Certificate (which the Issuer will be obligated to file with the Trustee prior to
the execution of any such supplemental indenture) with respect thereto. 
 Section 7.09 Increased Exchange Rate
Applicable to Certain Notes Surrendered in Connection with a Tax Redemption. 
 (a) If the Issuer elects to
effect a Tax Redemption and a Holder elects to exchange its Notes in connection with such Tax Redemption, the Issuer shall, under the circumstances described below, increase the Exchange Rate for the Notes so surrendered for exchange by a number of
Additional Shares pursuant to this Section 7.09. A exchange of Notes shall be deemed for these purposes to be “in connection with” such Tax Redemption if such exchange occurs during the period from, and including, the date on which
the Issuer provides such Notice of Tax Redemption to Holders until the Close of Business on the Business Day immediately preceding the applicable Redemption Date or, if the Issuer fails to pay the Redemption Price, such later date on which the
Issuer pays the Redemption Price. The Issuer shall comply with its obligations under Section 5.02(b) simultaneously with providing such Notice of Tax Redemption. 

(b) The Issuer will settle exchanges of Notes exchanged in connection with a Tax Redemption as provided in
Section 7.03 and, for the avoidance of doubt, pay Additional Amounts, if any, with respect to any such exchange. 

  
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 (c) The number of Additional Shares by which the Exchange Rate will be
increased for a exchange of Notes in connection with a Tax Redemption will be determined by reference to the table under Section 7.06, based on the applicable Redemption Reference Date and the applicable Redemption Reference Price, but
determined for purposes of this Section 7.09 as if (i) the Holder had elected to exchange its Notes in connection with a Make-Whole Fundamental Change, (ii) the applicable Redemption Reference Date were the “Make-Whole
Fundamental Change Effective Date” and (iii) the applicable Redemption Reference Price were the “ADS Price” (and subject, for the avoidance of doubt, to Section 7.06(e)). 

(d) If the Issuer has designated a Tax Redemption Date pursuant to Section 5.01(a), a Holder that complies with the
requirements for exchange set forth under Section 7.02(a) will be deemed to have delivered and not have withdrawn a Notice of Tax Redemption Election. 
 ARTICLE 8. 
 PURCHASE AT OPTION OF HOLDERS UPON A FUNDAMENTAL CHANGE AND ON AN
OPTIONAL PUT REPURCHASE DATE 
 Section 8.01 Fundamental Change Permits Holders to Require the Issuer to Repurchase the
Notes. 
 (a) General. If a Fundamental Change occurs at any time, then each Holder will have the
right, at such Holder’s option, to require the Issuer to repurchase for cash, at the Fundamental Change Repurchase Price, (i) all of such Holder’s Notes or (ii) any portion of such Holder’s Notes, which must be a principal
amount such that the principal amount of the Notes not so repurchased equals $200,000 or an integral multiple of $1,000 in excess thereof. 
 (b) Fundamental Change Repurchase Price. The “Fundamental Change Repurchase Price” means, for any Notes to be repurchased on a Fundamental Change Repurchase Date, a price equal to
100% of the principal amount of such Notes to be repurchased, plus accrued and unpaid interest to, but excluding, such Fundamental Change Repurchase Date; provided, however, that if a Fundamental Change Repurchase Date occurs after a Regular
Record Date, but on or prior to the Interest Payment Date corresponding to such Regular Record Date, the Issuer will instead pay the full amount of accrued and unpaid interest to the Holder of record on such Regular Record Date and the Fundamental
Change Repurchase Price will be equal to 100% of the principal amount of the Notes to be repurchased. 
 (c)
Fundamental Change Repurchase Date. The “Fundamental Change Repurchase Date” means, for any Fundamental Change, the date specified by the Issuer in the Fundamental Change Notice for such Fundamental Change, which date will be
not less than 20 Business Days, nor more than 35 Business Days, following the Fundamental Change Notice Date for such Fundamental Change. 
 Section 8.02 Fundamental Change Notice. 
 (a)
General. On or before the 20th calendar day after the occurrence of a Fundamental Change, the Issuer will deliver to each Holder, the Trustee and the Paying Agent a notice of the occurrence of such Fundamental Change and of the resulting
repurchase right (the “Fundamental Change Notice,” and the date of such delivery, the “Fundamental Change Notice Date”). Simultaneously with delivering any Fundamental Change Notice, the Issuer will publish notice
in a newspaper of general circulation in The City of New York, New York on the Issuer’s website, or through such other public medium as the Issuer may use at that time, which notice will contain the same information as such Fundamental Change
Notice. 
 For any Fundamental Change, the Fundamental Change Notice shall state: 

(i) the events causing such Fundamental Change and whether such transaction is also a Make-Whole Fundamental Change;

 (ii) the date of such Fundamental Change; 

  
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 (iii) the last date on which a Holder may exercise its right to require the
Issuer to repurchase its Notes as a result of such Fundamental Change under this Article 8; 
 (iv) the
Fundamental Change Repurchase Price for each $1,000 principal amount of Notes for such Fundamental Change; 

(v) the Fundamental Change Repurchase Date for such Fundamental Change; 

(vi) the name and address of the Paying Agent and, if applicable, the Exchange Agent; 

(vii) if applicable, the Exchange Rate and any adjustments to the Exchange Rate; 

(viii) if applicable, that the Notes with respect to which a Fundamental Change Repurchase Notice has been delivered by a
Holder may be exchanged only if such Holder withdraws such Fundamental Change Repurchase Notice in accordance with the terms of this Indenture or to the extent that a portion of such Notes is not subject to such Fundamental Change Repurchase Notice;
and 
 (ix) the procedures that a Holder must follow to require the Issuer to repurchase a Note. 

(b) Failure or Defect. Notwithstanding anything to the contrary contained elsewhere in this Indenture, neither the
failure of the Issuer to deliver a Fundamental Change Notice nor a defect in a Fundamental Change Notice delivered by the Issuer will limit the repurchase rights of any Holder under this Article 8 or impair or otherwise affect the validity of any
proceedings relating to the repurchase of any Note pursuant to this Article 8. 
 Section 8.03 Repurchase at Option of
Holders on Repurchase Dates. 
 (a) On January 19, 2017, January 19, 2022 and
January 19, 2027, (each a “Repurchase Date”), each Holder shall have the right, at such Holder’s option (the “Optional Put”), to require the Issuer to repurchase for cash all of such Holder’s Notes,
or any portion thereof so long as the principal amount of such Holder’s Notes not submitted for repurchase equals $200,000 or an integral multiple of $1,000 in excess thereof, at a repurchase price equal to 100% of the principal amount thereof,
plus accrued and unpaid interest thereon (including any Additional Interest, if any) to, but excluding, the Repurchase Date (the “Repurchase Price”), unless the Repurchase Date falls after a Regular Record Date but on or prior to
the Interest Payment Date to which such Regular Record Date relates, in which case the Issuer shall instead pay the full amount of accrued and unpaid interest to Holders as of such Regular Record Date, and the Repurchase Price shall be equal to 100%
of the principal amount of Notes to be repurchased pursuant to this Article 8. 
 (b) Repurchases of Notes
under this Section 8.03 shall be made, at the option of the Holder thereof, upon: 
 (i) delivery to the
Paying Agent by a Holder of a duly completed notice (the “Optional Put Notice”) in the form set forth Section 2.03, if the Notes are Physical Notes, or in compliance with the Depositary’s procedures for surrendering
interests in Global Notes, if the Notes are Global Notes, in each case at any time from the Open of Business on the date that is 20 Business Days prior to the relevant Repurchase Date until the Close of Business on the Business Day immediately
preceding the relevant Repurchase Date; and 
 (ii) delivery of the Notes, if the Notes are Physical Notes, to
the Paying Agent at any time after delivery of the Optional Put Notice (together with all necessary endorsements for transfer) at the Corporate Trust Office of the Paying Agent, or book-entry transfer of the Notes, if

  
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the Notes are Global Notes, in compliance with the procedures of the Depositary, in each case such delivery being a condition to receipt by the Holder of the Fundamental Change Repurchase Price
therefor. 
 The Optional Put Notice in respect of any Notes to be repurchased shall state: 

(i) in the case of Physical Notes, the certificate numbers of the Notes to be delivered for repurchase; 

(ii) the portion of the principal amount of Notes to be repurchased, which must be an amount such that the principal
amount of Notes not so repurchased equals $200,000 or an integral multiple of $1,000 in excess thereof; and 

(iii) that the Notes are to be repurchased by the Issuer pursuant to the applicable provisions of the Notes and this
Indenture; 
 provided, however, that if the Notes are Global Notes, the Fundamental Change Repurchase Notice must comply with
appropriate Depositary procedures. 
 Notwithstanding anything herein to the contrary, any Holder delivering to the Paying Agent
the Optional Put Notice contemplated by this Section 8.03 shall have the right to withdraw, in whole or in part, such Optional Put Notice at any time prior to the Close of Business on the Business Day immediately preceding the applicable
Repurchase Date by delivery of a written notice of withdrawal to the Paying Agent in accordance with Section 8.04. The notice of withdrawal shall state: 
 (i) the principal amount of Notes to be withdrawn, which must be such that the principal amount not to be repurchased equals $200,000 or an integral multiple of $1,000 in excess thereof; 

(ii) in the case of Physical Notes, the certificate numbers of the withdrawn Notes, or if not certificated the notice of
withdrawal must comply with appropriate Depositary procedures; and 
 (iii) the principal amount of Notes, if
any, which remains subject to the Optional Put Notice. 
 (c) On or before the 20th Business Day prior to each
Repurchase Date, the Issuer shall give notice (the “Optional Put Company Notice”) to all Holders of Notes and the Trustee and the Paying Agent (in the case of a Paying Agent other than the Trustee) at the applicable address shown in
the Register of the Registrar of the Repurchase Date and the repurchase right at the option of the Holders arising as a result thereof. Such notice shall be by first class mail or, in the case of Global Notes, in accordance with the Applicable
Procedures of the Depositary. Simultaneously with providing such notice, the Issuer shall publish a notice containing the information set forth in the Optional Put Company Notice in a newspaper of general circulation in The City of New York or
publish such information on the Issuer’s website or through such other public medium as the Issuer may use at that time. Each Optional Put Company Notice shall specify: 

(i) that Holders have the right to require the Issuer to purchase all or any portion of their Notes pursuant to this
Section 8.03; 
 (ii) the applicable Repurchase Date; 

(iii) the last date on which a Holder may exercise the repurchase right pursuant to this Article 8; 

  
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 (iv) the Repurchase Price; 

(v) the name and address of the Paying Agent; 

(vi) if applicable, that the Notes with respect to which an Optional Put Notice has been delivered by a Holder may be
exchanged only if the Holder withdraws the Optional Put Notice in accordance with the terms of this Indenture; and 
 (vii) the procedures that Holders must follow to require the Issuer to repurchase their Notes. 
 No failure of the Issuer to give the foregoing notices and no defect therein shall limit the Holders’ repurchase rights or affect the validity of the proceedings for the repurchase of the Notes
pursuant to this Section 8.03. 
 At the Issuer’s written request, the Trustee shall give such notice
in the Issuer’s name and at the Issuer’s expense; provided, however, that, in all cases, the text of such Optional Put Company Notice shall be prepared by the Issuer. Neither the Trustee nor the Paying Agent shall be responsible for
determining if an Repurchase Date is forthcoming or has occurred or for delivering an Optional Put Company Notice to Holders. 
 (d) Notwithstanding the foregoing, no Notes may be repurchased by the Issuer on any Repurchase Date if the principal amount of the Notes has been accelerated, and such acceleration has not been rescinded,
on or prior to such date (except in the case of an acceleration resulting from a Default by the Issuer in the payment of the Repurchase Price with respect to such Notes). The Paying Agent will promptly return to the respective Holders thereof any
Physical Notes held by it during the acceleration of the Notes (except in the case of an acceleration resulting from a Default by the Issuer in the payment of the Repurchase Price with respect to such Notes), or any instructions for book-entry
transfer of the Notes in compliance with the procedures of the Depositary shall be deemed to have been cancelled, and, upon such return or cancellation, as the case may be, the Optional Put Notice with respect thereto shall be deemed to have been
withdrawn. 
 Section 8.04 [Reserved.] 
 Section 8.05 Fundamental Change Repurchase Notice. 
 (a) General. To exercise its repurchase rights under Section 8.01(a) hereof with respect to any Fundamental Change, a Holder must deliver to the Paying Agent, by the Close of Business on the
Business Day immediately preceding the Fundamental Change Repurchase Date: 
 (i) a duly completed “Form of
Fundamental Change Repurchase Notice” in the form of Attachment 2 of the Notes that such Holder is tendering for repurchase (a “Fundamental Change Repurchase Notice”); and 

(ii) the Notes that such Holder is tendering for repurchase, (A) by book-entry transfer if such Notes are Global
Notes, or (B) by physical delivery, if such Notes are Physical Notes, in each case, together with any endorsements or other documents reasonably requested by the Paying Agent. 

(b) Contents of Fundamental Change Repurchase Notice. The Fundamental Change Repurchase Notice for any Note must
state: 
 (i) if such Note is to be repurchased in part, the principal amount of such Note to be repurchased,
which results in the principal amount of the Notes not so repurchased to equal $200,000 or an integral multiple of $1,000 in excess thereof; 

  
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 (ii) that such Note will be repurchased by the Issuer pursuant to the
provisions of this Article 8; and 
 (iii) if such Note to be repurchased is a Physical Note, the certificate
number of such Note. 
 If the Notes to be repurchased are Global Notes, the Fundamental Change Notice for such Notes must comply
with the Applicable Procedures. 
 (c) Notices to Company. If any Holder validly delivers to the Paying
Agent a Fundamental Change Repurchase Notice with respect to any Note or any portion of a Note, the Paying Agent will promptly deliver to the Issuer a copy of such Fundamental Change Repurchase Notice. 

(d) Effect of Improper Notice. Unless and until the Paying Agent receives a validly endorsed and delivered
Fundamental Change Repurchase Notice with respect to a Note, together with such Note, in a form that conforms with the description contained in such Fundamental Change Repurchase Notice, the Holder submitting the Notes will not be entitled to
receive the Fundamental Change Repurchase Price for such Note. 
 Section 8.06 Withdrawal of Fundamental Change
Repurchase Notice or Repurchase Notice. 
 (a) General. If a Holder delivers a Fundamental
Change Repurchase Notice or Repurchase Notice with respect to any Note, such Holder may withdraw such Fundamental Change Repurchase Notice or Repurchase Notice by delivering to the Paying Agent a written notice of withdrawal prior to the Close of
Business on the Business Day immediately preceding the Fundamental Change Repurchase Date or Repurchase Date, as applicable. Any such withdrawal notice must state: 

(i) the principal amount of the Notes to be withdrawn; 

(ii) the principal amount of the Notes that remains subject to the original Fundamental Change Repurchase Notice or
Optional Put Notice, as applicable; and 
 (iii) if the Notes with respect to which such Fundamental Change
Repurchase Notice or Optional Put Notice pertained were Physical Notes, the certificate numbers of the Notes to be withdrawn and the Notes that will remain subject to the Fundamental Change Repurchase Notice or Optional Put Notice, as applicable.

 If the Notes to be withdrawn are Global Notes, a Holder must deliver its notice of withdrawal in compliance with the
Applicable Procedures. 
 (b) Return of Note. Upon receipt of a validly delivered withdrawal notice, the
Paying Agent will promptly (i) if such notice pertains to a Physical Note or a portion of a Physical Note, return such Note or portion of a Note to such Holder, in the amount specified in such withdrawal notice; and, (ii) if such notice
pertains to a beneficial interest in a Global Note, in compliance with the Applicable Procedures, deem to be cancelled any instructions for book-entry transfer of such beneficial interest, in the amount specified in such withdrawal notice.

 (c) Notice to Company. If any Holder validly delivers to the Paying Agent a notice of withdrawal with
respect to a Note or any portion of a Note, the Paying Agent will promptly deliver to the Issuer a copy of such notice of withdrawal. 
 Section 8.07 Effect of Fundamental Change Repurchase Notice or Optional Put Notice. 
 (a) General. If a Holder validly delivers to the Paying Agent a Fundamental Change Repurchase Notice or Optional Put Notice (together with all necessary endorsements) with respect to any

  
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Note or any portion of any Note, such Holder may no longer exchange such Note or portion of a Note, as the case may be, unless and until such Holder validly withdraws such Fundamental Change
Repurchase Notice or Optional Put Notice, as applicable, in accordance with Section 8.06 hereof. 
 (b)
Timing of Payment. Upon the Paying Agent’s receipt of (i) a valid Fundamental Change Repurchase Notice or Optional Put Notice (together with all necessary endorsements) and (ii) the Notes to which such Fundamental Change
Repurchase Notice or Optional Put Notice, as applicable, pertains, the Holder of the Notes to which such Fundamental Change Repurchase Notice or Repurchase Notice, as applicable, pertains will be entitled, except to the extent such Holder has
validly withdrawn such Fundamental Change Repurchase Notice or Optional Put Notice in accordance with Section 8.06 hereof, to receive the Fundamental Change Repurchase Price or Repurchase Price with respect to such Notes on the later of
(i) the Fundamental Change Repurchase Date or Repurchase Date and (ii)(A) if such Notes are Physical Notes, the date of delivery of such Notes to the Paying Agent, or (B) if such Notes are Global Notes, the date of book-entry transfer of
such Notes to the Paying Agent, or, if such later date is not a Business Day, the Business Day immediately following such later date. 
 (c) Effect of Deposit. If, by 10:00 a.m., New York City time, on the Fundamental Change Repurchase Date for any Fundamental Change, the Paying Agent holds money sufficient to pay the
Fundamental Change Repurchase Price or Repurchase Price for every Note subject to a Fundamental Change Repurchase Notice or Optional Put Notice, as applicable, validly delivered in accordance with Section 8.05 hereof and not validly withdrawn
in accordance with Section 8.06 hereof, then, at the Close of Business on the Fundamental Change Repurchase Date or Repurchase Date, as applicable: 
 (i) the Notes to be repurchased will cease to be outstanding and interest will cease to accrue on such Notes (whether or not book-entry transfer of such Notes is made or whether or not such Notes are
delivered to the Paying Agent); and 
 (ii) all other rights of the Holders with respect to such Notes will
terminate (other than the right to receive the Fundamental Change Repurchase Price or Repurchase Price, as applicable, and previously accrued and unpaid interest, including Additional Interest, if any, upon delivery or transfer of the Notes).

 Section 8.08 Notes Repurchased in Whole or in Part. If any Physical Note is to be repurchased only in
part, the Holder must surrender such Note at the office of the Paying Agent (with, if the Issuer or the Trustee so requires, due endorsement by, or a written instrument of transfer in form satisfactory to the Issuer and the Trustee duly executed by,
the Holder of such Note or such Holder’s attorney-in-fact duly authorized in writing), whereupon the Issuer will execute, in accordance with Section 3.04, and the Trustee will authenticate, in accordance with Section 3.04, and deliver
to the surrendering Holder, without a service charge, a new Note or Notes of any authorized denomination or denominations requested by such Holder in aggregate principal amount equal to the portion of the principal amount of the Note so surrendered
which is not repurchased. If any Global Note is repurchased in part, the Issuer will instruct the Note Registrar to decrease the principal amount of such Global Note by the principal amount repurchased. Any Notes that are repurchased or owned by the
Issuer, whether or not in connection with a Fundamental Change or with exercise of an Optional Put, will be submitted to the Trustee for cancellation and will be duly retired by the Issuer. 

Section 8.09 Covenant to Comply with Securities Laws upon Repurchase of Notes. In connection with any repurchase
offer pursuant to a Fundamental Change Repurchase Notice or Optional Put Notice under this Article 8, the Guarantor will, to the extent applicable, (i) comply with Rule 13e-4 and any other tender offer rules under the Exchange Act that may be
applicable at the time of the offer to repurchase the Notes, (ii) file the related Schedule TO (or any successor schedule, form or report) or any other required schedule under the Exchange Act, and (iii) otherwise comply with any
applicable United States federal and state securities laws applicable to it in connection with such repurchase offer so as to permit Holders to exercise their rights and obligations under Section 8.01 hereof in the time and in the manner
specified in Sections 8.01 and 8.03 hereof. 
 Section 8.10 Deposit Fundamental Change Repurchase Price or
Repurchase Price. By 10:00 a.m., New York City time, on the Fundamental Change Repurchase Date or Repurchase Date, as applicable, the Issuer 

  
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will deposit with the Trustee or with the Paying Agent (or, if the Issuer or a Subsidiary or an Affiliate of either of them is acting as the Paying Agent, will segregate and hold in trust as
provided in Section 11.06) an amount of immediately available funds sufficient to pay the Fundamental Change Repurchase Price or Repurchase Price of all the Notes or portions thereof that the Issuer is required to repurchase on such Fundamental
Change Repurchase Date or Repurchase Date. 
 Section 8.11 Covenant Not to Repurchase Notes upon Certain Events of
Default. 
 (a) General. Notwithstanding anything to the contrary in this Article 8, no
Notes may be repurchased at the option of Holders upon a Fundamental Change or upon exercise of Optional Put if the principal amount of the Notes has been accelerated, and such acceleration has not been rescinded, on or prior to such date (except in
the case of an acceleration resulting from a default by the Issuer that would be cured by the Issuer’s payment of the Fundamental Change Repurchase Price or Repurchase Price, as applicable, with respect to such Notes). 

(b) Deemed Withdrawals. If, on any Fundamental Change Repurchase Date or Repurchase Date, (i) a Fundamental
Change Repurchase Notice or Optional Put Notice for a Note has been validly tendered in accordance with Section 8.05 hereof and has not been validly withdrawn in accordance with Section 8.05 hereof, and (ii) pursuant to this
Section 8.11, the Issuer is not permitted to purchase Notes, the Paying Agent will deem such Fundamental Change Repurchase Notice or Optional Put Notice withdrawn. 

(c) Return of Notes. If a Holder tenders a Note for purchase pursuant to this Article 8 and, on the Fundamental
Change Repurchase Date or Repurchase Date, pursuant to this Section 8.11, the Issuer is not permitted to purchase such Note, the Paying Agent will (i) if such Note is a Physical Note, return such Note to such Holder, and (ii) if such
Note is held in book-entry form, in compliance with the Applicable Procedures, deem to be cancelled any instructions for book-entry transfer of such Note. 
 ARTICLE 9. 
 EVENTS OF DEFAULT; REMEDIES 

Section 9.01 Events of Default. 
 (a) General. Each of the following is an “Event of Default” with respect to the Notes: 
 (i) the Issuer shall fail to pay an installment of interest, if any, on any of the Notes, which failure continues for 30 days after the date when due; 

(ii) the Issuer shall fail to pay when due the principal of any Note when the same becomes due and payable at its stated
maturity, upon redemption, upon required repurchase, upon declaration of acceleration or otherwise; 
 (iii) the
Issuer shall fail to deliver when due any part of the Exchange Obligation with respect to any Note in accordance with Article 7 hereof and such failure continues for five Business Days; 

(iv) the Issuer shall fail to comply with its notice obligations under Article 8, Section 7.01(c), Section 7.06
or Section 7.09 of this Indenture; 
 (v) the Issuer or the Guarantor shall fail to comply with its
respective obligations under Article 10 of this Indenture; 
 (vi) the Issuer shall fail to perform or observe
(or obtain a waiver with respect to) any term, covenant or agreement contained in the Notes or this Indenture and not otherwise explicitly provided for in this Section 9.01(a) for a period of 60 days after receipt by the Issuer of notice of
such failure from the Trustee or by the Issuer and the Trustee from the Holders of at least 25% of the aggregate principal amount of then outstanding Notes; 

  
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 (vii) the Issuer, the Guarantor or any of the Guarantor’s other
Subsidiaries shall be in default with respect to any mortgage, agreement or other instrument under which there may be outstanding, or by which there may be secured or evidenced, any indebtedness for money borrowed in excess of $20.0 million (or its
foreign currency equivalent at the time) in the aggregate of the Issuer, the Guarantor and/or any of its other Subsidiaries at any one time outstanding, whether such indebtedness exists as of the date hereof or shall thereafter be created
(x) resulting in such indebtedness becoming or being declared due and payable or (y) constituting a failure to pay the principal or interest of any such indebtedness when due and payable at its stated maturity, upon redemption, upon
required repurchase, upon declaration of acceleration or otherwise; 
 (viii) the Issuer or the Guarantor shall
have rendered against them or against any of the Guarantor’s other Subsidiaries by a court of competent jurisdiction a final judgment for the payment of $20.0 million (or its foreign currency equivalent at the time) or more (excluding any
amounts covered by insurance or bond), which judgment is not discharged, stayed, vacated, paid or otherwise satisfied within 60 days after (i) the date on which the right to appeal thereof has expired if no such appeal has commenced, or
(ii) the date on which all rights to appeal have been extinguished; 
 (ix) the Issuer, the Guarantor or
any of the Guarantor’s Subsidiaries that are Significant Subsidiaries, pursuant to or within the meaning of the Bankruptcy Law: 
 (A) commences as a debtor a voluntary case or proceeding; 
 (B)
consents to the entry of an order for relief against it in an involuntary case or proceeding or the commencement of any case against it; 
 (C) consents to the appointment of a Receiver of it or for all or substantially all of its property; 
 (D) makes a general assignment for the benefit of its creditors; 

(E) files a petition in bankruptcy or answer or consent seeking reorganization or relief; 

(F) consents to the filing of such a petition or the appointment of or taking possession by a Receiver; or 

(G) a court of competent jurisdiction enters an order or decree under any Bankruptcy Law that: 

(1) grants relief against the Issuer, the Guarantor or any of their respective subsidiaries in an involuntary case or
proceeding or adjudicates the Issuer, the Guarantor or any of their respective Subsidiaries insolvent or bankrupt; 
 (2) appoints a Receiver of the Issuer, the Guarantor or any of their respective Subsidiaries for all or substantially all of the property of the Issuer, the Guarantor or any of their respective
Subsidiaries; or 
 (3) orders the winding up or liquidation of the Issuer, the Guarantor or any of their
respective Subsidiaries; 

  
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 and, in each case, the order or decree remains unstayed and in effect for 60 consecutive
days. 
 (x) The Guarantee ceases to be in full force and effect (except as contemplated by the terms of this
Indenture) or is declared null and void in a judicial proceeding or the Guarantor denies or disaffirms its obligations under this Indenture or the Guarantee; or 

(xi) The Issuer fails to comply with its obligations under Section 4.06. 

(b) Cause Irrelevant. Each of the events enumerated in Section 9.01(a) hereof will constitute an Event of
Default whatever the cause and regardless of whether voluntary or involuntary or effected by operation of law or pursuant to any judgment, decree or order of any court or any order, rule or regulation of any administrative or governmental body.

 (c) Notice of Default or Event of Default. The Issuer shall deliver to the Trustee, as soon as
possible and in any event within 15 Business Days after the Issuer becomes aware of the occurrence of any Event of Default or an event which, with notice or the lapse of time or both, would constitute an Event of Default, an Officer’s
Certificate setting forth the details of such Event of Default or default and the action which the Issuer proposes to take with respect thereto. 
 (d) Waiver of Events of Default. Notwithstanding Section 9.01(a)(vii) or Section 9.02, in the event of any Event of Default specified in Section 9.01(a)(vii), such Event of Default
and all consequences thereof (excluding any resulting payment default) shall be annulled, waived and rescinded, automatically and without any actions by the Holders, if within 20 days after such Event of Default arose: 

(i) the indebtedness or guarantee that is the basis for such Event of Default has been discharged; 

(ii) the holders thereof have rescinded or waived the acceleration, notice or action (as the case may be) giving rise to
such Event of Default; or 
 (iii) if the Default that is the basis for such Event of Default has been cured.

 Section 9.02 Acceleration. 

(a) Automatic Acceleration in Certain Circumstances. If an Event of Default specified in Sections 9.01(a)(ix)
hereof occurs with respect to the Issuer, the principal amount of and accrued and unpaid interest, if any, on all of the then outstanding Notes will immediately become due and payable without any further action or notice by any party. 

(b) Optional Acceleration. If any other Event of Default occurs and is continuing, the Trustee by notice to the
Issuer, or the Holders of at least 25% in aggregate principal amount of then outstanding Notes by notice to the Issuer and the Trustee, may, and the Trustee at the request of such Holders shall, declare the principal amount of and accrued and unpaid
interest, if any, on all the outstanding Notes to be due and payable. Upon such a declaration of acceleration, such principal and accrued and unpaid interest, if any, will be due and payable immediately. 

(c) Rescission of Events of Default and/or Acceleration. Notwithstanding anything to the contrary in this
Indenture, the Holders of a majority in principal amount of then outstanding Notes may waive all past Events of Default (except with respect to nonpayment of principal (including the Fundamental Change Repurchase Price and Repurchase Price) or
interest or with respect to the Issuer’s failure to deliver the Exchange Obligation as required under Article 7 hereof) and rescind any such acceleration with respect to the Notes and its consequences hereunder by delivering notice to the
Trustee if (i) rescission would not conflict with any judgment or decree of a court of competent jurisdiction, (ii) all existing Events of Default, other than the nonpayment of the principal of and interest on the Notes that have become
due solely by such declaration of acceleration, have been cured or waived and (iii) all payments due under this Indenture to the Trustee have been made. 

  
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 Section 9.03 Other Remedies. If an Event of Default occurs and is continuing,
the Trustee may pursue any available remedy to collect the payment of the principal of, accrued and unpaid interest on, or the Fundamental Change Repurchase Price or Repurchase Price for, the Notes or to enforce the performance of any provision of
the Notes or this Indenture. 
 The Trustee may maintain a proceeding even if it does not possess any of the Notes not produce
any of the Notes in the proceeding. A delay or omission by the Trustee or any Holder in exercising any right or remedy accruing upon an Event of Default will not impair the right or remedy or constitute a waiver of or acquiescence in the Event of
Default. No remedy is exclusive of any other remedy. All available remedies are cumulative. 
 Section 9.04 Sole Remedy
for Failure to Report. 
 (a) General. Notwithstanding anything to the contrary in the Notes or in
this Indenture, to the extent the Issuer elects, the sole remedy for an Event of Default relating to (i) the Issuer’s failure to file with the Trustee pursuant to Section 314(a)(1) of the Trust Indenture Act any documents or reports
that the Guarantor is required to file with the SEC pursuant to Section 13 or 15(d) of the Exchange Act or (ii) the Guarantor’s failure to comply with its reporting obligations under Section 4.10 (any such Event of Default, a
“Reporting Default”), will, for the first 360 days after the occurrence of such Reporting Default, consist exclusively of the right to receive additional interest on the Notes (“Additional Interest”) at a rate equal
to (x) 0.25% per annum of the principal amount of then outstanding Notes for each day during the first 180 days after the occurrence of such Reporting Default and (y) 0.50% per annum on the principal amount of then outstanding
Notes from the 181st day until the 360th day following the occurrence of such Reporting Default during which Reporting Default is continuing. 
 If the Issuer so elects, such Additional Interest will be payable in the same manner and on the same dates as the stated interest payable on the Notes and will be separate and distinct from, and in
addition to, any Additional Interest that may accrue pursuant to Section 4.07. 
 (b) Company
Election. In order to elect to pay the Additional Interest as the sole remedy during the first 360 days after the occurrence of a Reporting Default in accordance with Section 9.04(a) hereof, the Issuer must notify all Holders, the
Trustee and the Paying Agent in writing of such election prior to the beginning of such 360-day period. 
 (c)
Limitation on Remedy. 
 (i) On the 361st day after the occurrence of such Reporting Default (if such
Reporting Default is not cured or waived prior to such 361st day), the Notes will immediately be subject to acceleration in accordance with Section 9.02 hereof. 

(ii) In addition, if a Reporting Default occurs and the Issuer fails to timely elect to pay Additional Interest pursuant
to Section 9.04(b) hereof, the Notes will immediately be subject to acceleration pursuant to Section 9.02 hereof on account of such Reporting Default. 

(iii) Notwithstanding anything to the contrary herein, if the Issuer elects to pay the Additional Interest with respect
to any Reporting Default, the Issuer’s election will not affect the rights of any Holder with respect to any other Event of Default. 
 Section 9.05 Waivers of Past Defaults. If an Event of Default or a Default, other than (a) an uncured Event of Default described in Sections 9.01(a)(i), 9.01(a)(ii) or 9.01(a)(iii)
hereof or (b) a Default in respect of a provision that under Section 14.01 hereof cannot be amended without the consent each affected Holder, the Holders of a majority in aggregate principal amount of the then outstanding Notes may waive
such Event of Default or Default and all of its consequences hereunder. Whenever any Event of Default is so waived, it will cease to exist, 

  
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and whenever any Default is so waived, it will be deemed cured, and any Event of Default arising therefrom will be deemed not to occur. However, no such waiver will extend to any subsequent or
other Default or Event of Default or impair any consequent right. 
 Section 9.06 Control By Majority. At any time,
the Holders of a majority of the aggregate principal amount of the then outstanding Notes may direct the time, method and place of conducting any proceeding for any remedy available to the Trustee or for exercising any trust or power conferred on
the Trustee. However, the Trustee may refuse to follow any direction that conflicts with law or this Indenture or, subject to the Trustee’s duties under Article 11 and the Trust Indenture Act, that the Trustee determines to be unduly
prejudicial to the rights of a Holder or to the Trustee, or that would potentially involve the Trustee in personal liability unless the Trustee is offered indemnity or security satisfactory to it against any loss, liability or expense to the Trustee
that may result from the Trustee’s instituting such proceeding as the Trustee. Prior to taking any action hereunder, the Trustee will be entitled to indemnification satisfactory to it against all losses and expenses caused by taking or not
taking such action. 
 Section 9.07 Limitation on Suits. Subject to Section 9.08 hereof, no Holder may pursue
a remedy with respect to this Indenture or the Notes unless: 
 (a) such Holder has previously delivered to the
Trustee written notice that an Event of Default has occurred and is continuing; 
 (b) the Holders of at least
25% of the aggregate principal amount of the then outstanding Notes deliver to the Trustee a written request that the Trustee pursue a remedy with respect to such Event of Default; 

(c) such Holder or Holders have offered and, if requested, provided to the Trustee security or indemnity satisfactory to
the Trustee against any loss, liability or other expense of compliance with such written request; 
 (d) the
Trustee has not complied with such written request within 60 days after receipt of such written request and offer of security or indemnity; and 
 (e) during such 60-day period, the Holders of a majority of the aggregate principal amount of the then outstanding Notes did not deliver to the Trustee a direction inconsistent with such written request.

 A Holder may not use this Indenture to prejudice the rights of any other Holder or to obtain a preference or priority over
any other Holder, it being understood that the Trustee does not have any affirmative duty to ascertain whether any usage of this Indenture by a Holder is unduly prejudicial to such other Holders. 

Section 9.08 Rights of Holders to Receive Payment and to Exchange. Notwithstanding anything to the contrary elsewhere in
this Indenture, the right of any Holder to receive payment of the principal of, Fundamental Change Repurchase Price or Repurchase Price for, Additional Amounts with respect to, and accrued and unpaid interest (including Additional Interest, if any)
on, its Notes, on or after the respective due date, and to exchange its Notes and receive the Exchange Obligation due with respect to such Notes in accordance with Article 7 hereof, or to bring suit for the enforcement of any such payment or
exchange rights, will not be impaired or affected without the consent of such Holder and will not be subject to the requirements of Section 9.07 hereof. 
 Section 9.09 Collection Suit by Trustee. If an Event of Default specified in Section 9.01(a)(i), 9.01(a)(ii) or 9.01(a)(iii) hereof occurs and is continuing or an acceleration pursuant to
Section 9.02 occurs and has not been waived or rescinded, the Trustee is authorized to recover judgment in its own name and as trustee of an express trust against the Issuer for the whole amount of principal of, interest (including Additional
Interest, if any) on, Fundamental Change Repurchase Price or Repurchase Price for, Additional Amounts with respect to, and Exchange Obligation with respect to, the Notes, as the case may be, and, to the extent lawful, any default interest on such
principal, interest and Fundamental Change Repurchase Price or Repurchase Price, and such further amount as is sufficient to cover the costs and expenses of collection, including the reasonable compensation, expenses, disbursements and advances of
the Trustee, its agents and counsel, as well as any other amounts that may be due under Section 11.07. 

  
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 Section 9.10 Trustee May Enforce Claims Without Possession of Notes. All rights
of action and claims under this Indenture or the Notes may be prosecuted and enforced by the Trustee without the possession of any of the Notes or the production thereof in any proceeding relating thereto, and any such proceeding instituted by the
Trustee shall be brought in its own name as trustee of an express trust, and any recovery of judgment shall, after provision for the payment of the reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and counsel,
be for the ratable benefit of the Holders in respect of which such judgment has been recovered. 
 Section 9.11 Trustee
May File Proofs of Claim. The Trustee is authorized to file such proofs of claim and other papers or documents as may be necessary or advisable to have the claims of the Trustee and the Holders allowed in any judicial proceedings relative to the
Issuer, its creditors or its property and, unless prohibited by law or applicable regulations, will be entitled to collect, receive and distribute any money or other property payable or deliverable on any such claims, and any Custodian in any such
judicial proceeding is hereby authorized by each Holder to make such payments to the Trustee, and, in the event that the Trustee consents to the making of such payments directly to the Holders, to pay to the Trustee any amount due to it for the
reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and counsel, and any other amounts due the Trustee under Section 11.07. To the extent that the payment of any such compensation, expenses, disbursements
and advances of the Trustee, its agents and counsel, and any other amounts due the Trustee under Section 11.07 out of the estate in any such proceeding, will be denied for any reason, payment of the same will be secured by a lien on, and is
paid out of, any and all distributions, dividends, money, securities and other properties that the Holders may be entitled to receive in such proceeding, whether in liquidation or under any plan of reorganization or arrangement or otherwise. Nothing
herein contained will be deemed to authorize the Trustee to authorize or consent to, or to accept or to adopt on behalf of any Holder, any plan of reorganization, arrangement, adjustment or composition affecting the Notes or the rights of any
Holder, or to authorize the Trustee to vote in respect of the claim of any Holder in any such proceeding. 
 Section 9.12
Restoration of Rights and Remedies. If the Trustee or any Holder has instituted any proceeding to enforce any right or remedy under this Indenture and such proceeding has been discontinued or abandoned for any reason, or has been determined
adversely to the Trustee or to such Holder, then and in every such case, subject to any determination in such proceeding, the Issuer, the Trustee and the Holders shall be restored severally and respectively to their former positions hereunder and
thereafter all rights and remedies of the Trustee and the Holders shall continue as though no such proceeding had been instituted. 
 Section 9.13 Rights and Remedies Cumulative. Except as otherwise provided with respect to the replacement or payment of mutilated, destroyed, lost or stolen Notes in Section 3.09, no
right or remedy herein conferred upon or reserved to the Trustee or to the Holders is intended to be exclusive of any other right or remedy, and every right and remedy shall, to the extent permitted by law, be cumulative and in addition to every
other right and remedy given hereunder or now or hereafter existing at law or in equity or otherwise. The assertion or employment of any right or remedy hereunder, or otherwise, shall not prevent the concurrent assertion or employment of any other
appropriate right or remedy. 
 Section 9.14 Delay or Omission Not a Waiver. No delay or omission of the Trustee or
of any Holder to exercise any right or remedy accruing upon any Event of Default shall impair any such right or remedy or constitute a waiver of any such Event of Default or an acquiescence therein. Every right and remedy given by this
Article 9 or by law to the Trustee or to the Holders may be exercised from time to time and as often as may be deemed expedient by the Trustee (subject to the limitations contained in this Indenture) or by the Holders, as the case may be.

 Section 9.15 Priorities. If the Trustee collects any money pursuant to this Article 9, it will pay out the
money in the following order: 
 FIRST: to the Trustee, its agents and attorneys for amounts due under Section 11.07,
including payment of all compensation, expenses and liabilities incurred, and all advances made, by the Trustee and the costs and expenses of collection; 

  
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 SECOND: to the Holders, for any amounts due and unpaid on the principal of, Redemption
Price, Fundamental Change Repurchase Price or Repurchase Price for, Additional Amounts with respect to, accrued and unpaid interest (including Additional Interest, if any) on, and cash portion of the Exchange Obligation with respect to, any Note,
without preference or priority of any kind, according to such amounts due and payable on all of the Notes; and 
 THIRD: the
balance, if any, to the Issuer or to such other party as a court of competent jurisdiction directs. 
 The Trustee may fix a
record date and payment date for any payment to the Holders pursuant to this Section 9.15. If the Trustee so fixes a record date and a payment date, at least 15 days prior to such record date, the Issuer will deliver to each Holder and the
Trustee a written notice, which notice will state such record date, such payment date and the amount of such payment. 

Section 9.16 Undertaking for Costs. All parties to this Indenture agree, and each Holder of a Note, by such Holder’s
acceptance thereof, shall be deemed to have agreed, that any court may in its discretion require, in any suit for the enforcement of any right or remedy under this Indenture, or in any suit against the Trustee for any action taken or omitted by it
as Trustee, the filing by any party litigant in such suit of an undertaking to pay the costs of such suit, and that such court may in its discretion assess reasonable costs, including reasonable attorneys’ fees and expenses, against any party
litigant in such suit, having due regard to the merits and good faith of the claims or defenses made by such party litigant; provided, however, that the provisions of this Section 9.16 shall not apply to any suit instituted by the
Trustee, to any suit instituted by any Holder, or group of Holders, holding in the aggregate more than 10% in aggregate principal amount of the Notes then outstanding, or to any suit instituted by any Holder for the enforcement of the payment of the
principal of, the Redemption Price, Fundamental Change Repurchase Price or Repurchase Price with respect to, Additional Amounts with respect to, or accrued and unpaid interest (including Additional Interest), if any, on, any Note on or after the due
date expressed or provided for in such Note or to any suit for the enforcement of the right to exchange any Note in accordance with the provisions of Article 7 hereof. 
 ARTICLE 10. 
 MERGER, CONSOLIDATION OR SALE OF ASSETS AND TAX RESIDENCE 

Section 10.01 Issuer and Guarantor May Consolidate on Certain Terms. Neither the Issuer nor the Guarantor shall consolidate
with or merge into any Person (unless the Issuer or the Guarantor, as applicable, is the surviving corporation) or enter into a scheme of arrangement or convey, transfer, lease or otherwise dispose of its respective properties and assets,
substantially as an entirety to another Person (other than for the Guarantor to convey, transfer lease or otherwise dispose of such assets or properties to one or more of its wholly-owned subsidiaries), unless the following conditions are met:

 (a) the Person (if other than the Issuer or the Guarantor, as applicable) formed by such consolidation or
into which the Issuer or the Guarantor, as applicable, is merged, or of which the Guarantor becomes a subsidiary pursuant to a scheme of arrangement or the Person which acquires by conveyance, transfer, lease or other disposition of all or
substantially all of the properties and assets of the Issuer or the Guarantor, as applicable (x) shall be a corporation, limited liability company, partnership, trust or other business entity organized and existing under the laws of the United
States of America, any State thereof, the District of Columbia, Ireland (meaning Ireland exclusive of Northern Ireland) or England and Wales and (y) such Person (if other than the Issuer or the Guarantor, as applicable) shall expressly assume,
by an indenture supplemental hereto, executed and delivered to the Trustee, in form satisfactory to the Trustee, the obligations of the Issuer or the Guarantor, as the case may be, under the Notes and this Indenture (including, for the avoidance of
doubt, the obligations under Section 4.16); 
 (b) immediately after giving effect to such transaction, no
Default or Event of Default shall have occurred and be continuing; 
 (c) if either the Issuer or the Guarantor,
as the case may be, will not be the resulting or surviving corporation, the Issuer or the Guarantor, as the case may be, shall have delivered to the Trustee an Officer’s Certificate and an Opinion of Counsel, each stating that such
consolidation, merger, sale, 

  
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conveyance, transfer or lease and, if a supplemental indenture is required in connection with such transaction, such supplemental indenture comply with this Indenture and that all conditions
precedent herein provided for relating to such transaction have been complied with; and 
 (d) if, upon the
occurrence of any such transaction (x) the Notes would become convertible or exchangeable pursuant to the terms of this Indenture into securities issued by an issuer other than the resulting, surviving, transferee or successor corporation and
(y) such resulting, surviving, transferee or successor corporation is a wholly owned Subsidiary of the issuer of such securities into which the notes have become exchangeable, such other issuer shall fully and unconditionally guarantee on a
senior basis the resulting, surviving, transferee or successor corporation’s obligations under the Notes and this Indenture. 
 No such consolidation, merger, sale, conveyance, transfer or lease shall be permitted by this Section 10.01 unless prior thereto the Guarantor (or the surviving Person with respect to the Guarantor)
shall have delivered to the Trustee an Officer’s Certificate and an Opinion of Counsel, each stating that the Guarantor’s (or such surviving Person’s) obligations hereunder shall remain in full force and effect thereafter or the
Guarantor (or such surviving Person) shall have reaffirmed its Guarantee pursuant to a notation of the Guarantee substantially in the form included in Section 2.03. 
 Section 10.02 Successor to Be Substituted. Successor to Be Substituted. Upon any consolidation by the Issuer or the Guarantor, as applicable, with or merger of the Issuer or the
Guarantor, as applicable, into any other Person or any sale, conveyance, transfer or lease of all or substantially all of the properties and assets of the Issuer or the Guarantor, as applicable, to any Person in accordance with Section 10.01,
the successor Person formed by such consolidation or into which the Issuer or the Guarantor, as applicable, is merged or to which such sale, conveyance, transfer or lease is made shall succeed to, and be substituted for, and may exercise every right
and power of, the Issuer or the Guarantor, as applicable, under this Indenture with the same effect as if such successor Person had been named as the Issuer or as the Guarantor, as applicable, herein, and thereafter, except in the case of a lease,
the predecessor Person shall be released from all obligations and covenants under this Indenture and the Notes. 
 In case of
any such consolidation, merger, sale, conveyance, transfer or lease, such changes in phraseology and form (but not in substance) may be made in the Notes thereafter to be issued as may be appropriate. 

Section 10.04 Assumption by Guarantor. The Guarantor, or a Subsidiary thereof, may directly assume, by an indenture
supplemental hereto, executed and delivered to the Trustee, in form satisfactory to the Trustee, the due and punctual payment of the principal of, any premium and interest and Additional Interest, if any, on all the Notes and the performance of
every covenant of this Indenture on the part of the Issuer to be performed or observed. Upon any such assumption, the Guarantor or such Subsidiary shall succeed to, and be substituted for and may exercise every right and power of, the Issuer under
this Indenture with the same effect as if the Guarantor or such Subsidiary had been named as the Issuer herein and the Issuer shall be released from all obligations and covenants with respect to the Notes. No such assumption shall be permitted
unless the Guarantor has delivered to the Trustee (i) an Officer’s Certificate of the Guarantor and an Opinion of Counsel, each stating that such assumption and supplemental indenture comply with this Article 10, and that all
conditions precedent herein provided for relating to such transaction have been complied with and that the Guarantee and all other covenants of the Guarantor herein remain in full force and effect and (ii) an opinion of independent counsel that
the Holders shall have no materially adverse United States federal tax consequences as a result of such assumption. 

Section 10.05 Change of Tax Residence. Neither the Guarantor nor the Issuer shall become a tax resident in a tax jurisdiction
other than Ireland unless becoming a tax resident in such jurisdiction will not provide the Issuer a right to redeem the Notes under Section 5.01(a) either under the laws in force at that time or announced at that time; provided that, the
Issuer will continue to have the benefit of Section 5.01(a) after such change of jurisdiction. 

  
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 ARTICLE 11. 
 THE TRUSTEE 
 Section 11.01 Duties and Responsibilities of Trustee.

 (a) The Trustee, prior to the occurrence of an Event of Default and after the curing of all Events of Default
which may have occurred, undertakes to perform such duties and only such duties as are specifically set forth in this Indenture. In case an Event of Default has occurred (which has not been cured or waived), the Trustee shall exercise such of the
rights and powers vested in it by this Indenture, and use the same degree of care and skill in their exercise, as a prudent person would exercise or use under the circumstances in the conduct of his own affairs. 

(b) No provision of this Indenture shall be construed to relieve the Trustee from liability for its own negligent action,
its own negligent failure to act or its own willful misconduct, except that: 
 (i) prior to the occurrence of
an Event of Default and after the curing or waiving of all Events of Default which may have occurred: 
 (A) the
duties and obligations of the Trustee shall be determined solely by the express provisions of this Indenture and applicable law, and the Trustee shall not be liable except for the performance of such duties and obligations as are specifically set
forth in this Indenture and no implied covenants or obligations shall be read into this Indenture against the Trustee; and 
 (B) in the absence of bad faith and willful misconduct on the part of the Trustee, the Trustee may conclusively rely as to the truth of the statements and the correctness of the opinions expressed
therein, upon any certificates or opinions furnished to the Trustee and conforming to the requirements of this Indenture; but, in the case of any such certificates or opinions which by any provisions hereof are specifically required to be furnished
to the Trustee, the Trustee shall be under a duty to examine the same to determine whether or not they conform to the requirements of this Indenture (but need not confirm or investigate the accuracy of any mathematical calculations or other facts
stated therein); 
 (ii) the Trustee shall not be liable for any error of judgment made in good faith by a Trust
Officer or Officers of the Trustee, unless the Trustee was negligent in ascertaining the pertinent facts; 

(iii) the Trustee shall not be liable with respect to any action taken or omitted to be taken by it in good faith in
accordance with the written direction of the Holders of not less than a majority in principal amount of the Notes at the time outstanding determined as provided in Section 1.04 relating to the time, method and place of conducting any proceeding
for any remedy available to the Trustee, or exercising any trust or power conferred upon the Trustee, under this Indenture; 
 (iv) whether or not therein provided, every provision of this Indenture relating to the conduct or affecting the liability of, or affording protection to, the Trustee shall be subject to the provisions of
this Section; 
 (v) the Trustee shall not be liable in respect of any payment (as to the correctness of amount,
entitlement to receive or any other matters relating to payment) or notice effected by the Issuer or any Paying Agent or any records maintained by any co-Registrar with respect to the Notes; and 

(vi) if any party fails to deliver a notice relating to an event the fact of which, pursuant to this Indenture, requires
notice to be sent to the Trustee, the Trustee may conclusively rely on its failure to receive such notice as reason to act as if no such event occurred. 
 None of the provisions contained in this Indenture shall require the Trustee to expend or risk its own funds or otherwise incur personal financial liability in the performance of any of its duties or in
the exercise of any of its rights or powers, if there is reasonable ground for believing that the repayment of such funds or adequate indemnity against such risk or liability is not reasonably assured to it. 

  
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 Section 11.02 Notice of Defaults. The Trustee shall give the Holders notice of
any Default of which a Trust Officer of the Trustee has knowledge or is deemed to have notice under Section 11.03(a) within 90 days after the occurrence thereof so long as such Default is continuing; provided, that (except in the case of any
Default in the payment of principal amount of, or interest on, any of the Notes or Fundamental Change Purchase Price or Repurchase Price or a default in the delivery of the consideration due upon exchange), the Trustee shall be protected in
withholding such notice if and so long as it in good faith determines that the withholding of such notice is in the interest of the Holders of Notes. 
 Section 11.03 Reliance on Documents, Opinions, Etc. Except as otherwise provided in Section 11.01: 

(a) the Trustee may conclusively rely and shall be protected in acting upon any resolution, certificate, statement,
instrument, opinion, report, notice, request, consent, order, bond, debenture, note, coupon or other paper or document (whether in its original or facsimile form) believed by it in good faith to be genuine and to have been signed or presented by the
proper party or parties; 
 (b) any request, direction, order or demand of the Issuer mentioned herein shall be
sufficiently evidenced by an Officer’s Certificate (unless other evidence in respect thereof be herein specifically prescribed); and any resolution of the Board of Directors may be evidenced to the Trustee by a copy thereof certified by the
Secretary, any Assistant Secretary or the General Counsel of the Issuer; 
 (c) the Trustee may consult with
counsel of its own selection and any advice or Opinion of Counsel shall be full and complete authorization and protection in respect of any action taken or omitted by it hereunder in good faith and in accordance with such advice or Opinion of
Counsel; 
 (d) the Trustee shall be under no obligation to exercise any of the rights or powers vested in it by
this Indenture at the request, order or direction of any of the Holders pursuant to the provisions of this Indenture (including upon the occurrence and during the continuance of an Event of Default), unless such Holders shall have offered to the
Trustee security or indemnity reasonably satisfactory to it against any loss, expenses and liabilities which may be incurred therein or thereby; 
 (e) the Trustee shall not be bound to make any investigation into the facts or matters stated in any resolution, certificate, statement, instrument, opinion, report, notice, request, direction, consent,
order, bond, debenture or other paper or document, but the Trustee, in its discretion, may make such further inquiry or investigation into such facts or matters as it may see fit, and, if the Trustee shall determine to make such further inquiry or
investigation, it shall be entitled to examine the books, records and premises of the Issuer, personally or by agent or attorney (at the reasonable expense of the Issuer and shall incur no liability of any kind by reason of such inquiry or
investigation); 
 (f) the Trustee may execute any of the trusts or powers hereunder or perform any duties
hereunder either directly or by or through agents or attorneys and the Trustee shall not be responsible for any misconduct or negligence on the part of any agent or attorney appointed by it with due care hereunder; 

(g) the Trustee shall not be liable for any action taken, suffered, or omitted to be taken by it in good faith and
reasonably believed by it to be authorized or within the discretion or rights or powers conferred upon it by this Indenture; 
 (h) in no event shall the Trustee be responsible or liable for special, indirect, consequential or punitive loss or damage of any kind whatsoever (including, but not limited to, loss of profit)
irrespective of whether the Trustee has been advised of the likelihood of such loss or damage and regardless of the form of action; 

  
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 (i) the Trustee shall not be deemed to have notice of any Default or Event
of Default unless a Trust Officer of the Trustee has actual knowledge thereof or unless written notice of any event which is in fact such a default is received by the Trustee at the Corporate Trust Office of the Trustee, and such notice references
the Notes and the Indenture; 
 (j) the rights, privileges, protections, immunities and benefits given to the
Trustee, including, without limitation, its right to be indemnified, are extended to, and shall be enforceable by, the Trustee in each of its capacities hereunder, and each agent, custodian and other Person employed to act hereunder; 

(k) the Trustee shall not be required to give any bond or surety in respect of the performance of its powers and duties
hereunder; and 
 (l) the Trustee may request that the Company deliver a certificate setting forth the names of
individuals and/or titles of officers authorized at such time to take specified actions pursuant to this Indenture. 

Section 11.04 No Responsibility for Recitals, Etc. The recitals contained herein and in the Notes (except in the
Trustee’s certificate of authentication) shall be taken as the statements of the Issuer, and the Trustee assumes no responsibility for the correctness of the same. The Trustee makes no representations as to the validity or sufficiency of this
Indenture or of the Notes. The Trustee shall not be accountable for the use or application by the Issuer of any Notes or the proceeds of any Notes authenticated and delivered by the Trustee in conformity with the provisions of this Indenture.

 Section 11.05 Trustee, Paying Agents, Exchange Agents or Registrar May Own Notes. The Trustee, any Paying Agent,
any Exchange Agent or Registrar, in its individual or any other capacity, may become the owner or pledgee of Notes with the same rights it would have if it were not Trustee, Paying Agent, Exchange Agent or Registrar. 

Section 11.06 Monies to be Held in Trust. Subject to the provisions of Section 13.04, all monies and properties
received by the Trustee shall, until used or applied as herein provided, be held in trust for the purposes for which they were received. Money held by the Trustee in trust hereunder need not be segregated from other funds except to the extent
required by law. The Trustee shall be under no liability for interest on any money received by it hereunder except as may be agreed in writing from time to time by the Issuer and the Trustee. 

Section 11.07 Compensation and Expenses of Trustee. The Issuer covenants and agrees to pay to the Trustee from time to time,
and the Trustee shall be entitled to, such compensation for all services rendered by it hereunder in any capacity (which shall not be limited by any provision of law in regard to the compensation of a trustee of an express trust) as mutually agreed
to from time to time in writing between the Issuer and the Trustee, and the Issuer will pay or reimburse the Trustee upon its request for all reasonable expenses, disbursements and advances reasonably incurred or made by the Trustee in accordance
with any of the provisions of this Indenture (including the reasonable compensation and the expenses and disbursements of its counsel and of all Persons not regularly in its employ) except any such expense, disbursement or advance as may arise from
its negligence or willful misconduct. The Issuer also covenants to indemnify the Trustee (or any officer, director or employee of the Trustee), in any capacity under this Indenture and its agents and any authenticating agent for, and to hold them
harmless against, any and all loss, liability, claim or expense incurred without negligence or willful misconduct on the part of the Trustee or such officers, directors, employees and agent or authenticating agent, as the case may be, and arising
out of or in connection with the acceptance or administration of this trust or in any other capacity hereunder (including, without limitation, in respect of any payment of the Redemption Price in connection with the ability of Holders to surrender
Notes for exchange during the period specified in Section 7.01(d) and Section 7.01(e), as the case may be, in connection with the Issuer’s election to effect a Tax Redemption or an Optional Redemption, as the case may be), including
the costs and expenses of defending themselves against any claim (whether asserted by the Issuer, the Guarantor, a Holder or any other Person) of liability in the premises. The obligations of the Issuer under this Section 11.07 to compensate or
indemnify the Trustee and to pay or reimburse the Trustee for expenses, disbursements and advances shall be secured by a lien prior to that of the Notes upon all property and funds held or collected by the Trustee as such, except funds held in trust
for the benefit of the Holders of particular Notes. The obligation of the Issuer under this Section shall survive the satisfaction and discharge of this Indenture. 

  
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 When the Trustee and its agents and any authenticating agent incur expenses or render
services after an Event of Default specified in Section 9.01(a)(ix) with respect to the Issuer occurs, the expenses and the compensation for the services are intended to constitute expenses of administration under any bankruptcy, insolvency or
similar laws. 
 Section 11.08 Officer’s Certificate as Evidence. Except as otherwise provided in
Section 11.01, whenever in the administration of the provisions of this Indenture the Trustee shall deem it necessary or desirable that a matter be proved or established prior to taking or omitting any action hereunder, such matter (unless
other evidence in respect thereof be herein specifically prescribed) may, in the absence of negligence or willful misconduct on the part of the Trustee, be deemed to be conclusively proved and established by an Officer’s Certificate delivered
to the Trustee. 
 Section 11.09 Conflicting Interests of Trustee. If the Trustee has or shall acquire a
conflicting interest within the meaning of the Trust Indenture Act, the Trustee shall either eliminate such interest or resign, to the extent and in the manner provided by, and subject to the provisions of, this Indenture. 

Section 11.10 Eligibility of Trustee. There shall at all times be a Trustee hereunder which shall be a Person that is
eligible pursuant to the Trust Indenture Act to act as such and has a combined capital and surplus of at least $50,000,000 (or if such Person is a member of a bank holding company system, its bank holding company shall have a combined capital and
surplus of at least $50,000,000). If such Person publishes reports of condition at least annually, pursuant to law or to the requirements of any supervising or examining authority, then for the purposes of this Section the combined capital and
surplus of such Person shall be deemed to be its combined capital and surplus as set forth in its most recent report of condition so published. If at any time the Trustee shall cease to be eligible in accordance with the provisions of this
Section 11.10, it shall resign immediately in the manner and with the effect hereinafter specified in this Article. 

Section 11.11 Resignation or Removal of Trustee. 

(a) The Trustee may at any time resign by giving written notice of such resignation to the Issuer and to the Holders of
Notes. Upon receiving such notice of resignation, the Issuer shall promptly appoint a successor trustee by written instrument, in duplicate, executed by order of the Board of Directors, one copy of which instrument shall be delivered to the
resigning Trustee and one copy to the successor trustee. If no successor trustee shall have been so appointed and have accepted appointment sixty (60) days after the mailing of such notice of resignation to the Holders, the resigning Trustee
may, upon ten (10) Business Days’ notice to the Issuer and the Holders, appoint a successor identified in such notice or may petition, at the expense of the Issuer, any court of competent jurisdiction for the appointment of a successor
trustee, or, if any Holder who has been a bona fide Holder of a Note or Notes for at least six (6) months may, subject to the provisions of Section 9.16, on behalf of himself and all others similarly situated, petition any such court for
the appointment of a successor trustee. Such court may thereupon, after such notice, if any, as it may deem proper and prescribe, appoint a successor trustee. 
 (b) In case at any time any of the following shall occur: 
 (i)
the Trustee shall fail to comply with Section 11.09 after written request therefor by the Issuer or by any Holder who has been a bona fide Holder of a Note or Notes for at least six (6) months; or 

(ii) the Trustee shall cease to be eligible in accordance with the provisions of Section 11.10 and shall fail to
resign after written request therefor by the Issuer or by any such Holder; or 

  
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 (iii) the Trustee shall become incapable of acting, or shall be adjudged a
bankrupt or insolvent, or a receiver of the Trustee or of its property shall be appointed, or any public officer shall take charge or control of the Trustee or of its property or affairs for the purpose of rehabilitation, conservation or
liquidation; 
 then, in any such case, the Issuer may remove the Trustee and appoint a successor trustee by written instrument,
in duplicate, executed by order of the Board of Directors, one copy of which instrument shall be delivered to the Trustee so removed and one copy to the successor trustee, or, subject to the provisions of Section 9.16, any Holder who has been a
bona fide Holder of a Note or Notes for at least six (6) months may, on behalf of himself and all others similarly situated, petition any court of competent jurisdiction for the removal of the Trustee and the appointment of a successor trustee;
provided, however, that if no successor Trustee shall have been appointed and have accepted appointment sixty (60) days after either the Issuer or the Holders has removed the Trustee, the Trustee so removed may petition at the
Issuer’s expense any court of competent jurisdiction for an appointment of a successor trustee. Such court may thereupon, after such notice, if any, as it may deem proper and prescribe, remove the Trustee and appoint a successor trustee.

 (c) The Holders of a majority in aggregate principal amount of the Notes at the time outstanding may at any
time remove the Trustee and nominate a successor trustee which shall be deemed appointed as successor trustee unless, within ten (10) days after notice to the Issuer of such nomination, the Issuer objects thereto, in which case the Trustee so
removed or any Holder, or if such Trustee so removed or any Holder fails to act, the Issuer, upon the terms and conditions and otherwise as in Section 11.11(a) provided, may petition any court of competent jurisdiction for an appointment of a
successor trustee. 
 (d) Any resignation or removal of the Trustee and appointment of a successor trustee
pursuant to any of the provisions of this Section 11.11 shall become effective upon acceptance of appointment by the successor trustee as provided in Section 11.12. 
 Section 11.12 Acceptance by Successor Trustee. Any successor trustee appointed as provided in Section 11.11 shall execute, acknowledge and deliver to the Issuer and to its predecessor
trustee an instrument accepting such appointment hereunder, and thereupon the resignation or removal of the predecessor trustee shall become effective and such successor trustee, without any further act, deed or conveyance, shall become vested with
all the rights, powers, duties and obligations of its predecessor hereunder, with like effect as if originally named as trustee herein; but, nevertheless, on the written request of the Issuer or of the successor trustee, the trustee ceasing to act
shall, upon payment of any amount then due it pursuant to the provisions of Section 11.07, execute and deliver an instrument transferring to such successor trustee all the rights and powers of the trustee so ceasing to act. Upon request of any
such successor trustee, the Issuer shall execute any and all instruments in writing for more fully and certainly vesting in and confirming to such successor trustee all such rights and powers. Any trustee ceasing to act shall, nevertheless, retain a
lien upon all property and funds held or collected by such trustee as such, except for funds held in trust for the benefit of Holders of particular Notes, to secure any amounts then due it pursuant to the provisions of Section 11.07.

 No successor trustee shall accept appointment as provided in this Section 11.12 unless, at the time of such acceptance,
such successor trustee shall be qualified under the provisions of Section 11.09 and be eligible under the provisions of Section 11.10. 
 Upon acceptance of appointment by a successor trustee as provided in this Section 11.12, the Issuer (or the former trustee, at the written direction of the Issuer) shall mail or cause to be mailed
notice of the succession of such trustee hereunder to the Holders of Notes at their addresses as they shall appear on the Register. If the Issuer fails to mail such notice within ten (10) days after acceptance of appointment by the successor
trustee, the successor trustee shall cause such notice to be mailed at the expense of the Issuer. 
 Section 11.13
Succession by Merger, Etc. Any corporation into which the Trustee may be merged or exchanged or with which it may be consolidated, or any corporation resulting from any merger, exchange or consolidation to which the Trustee shall be a party,
or any corporation succeeding to all or substantially all of the corporate trust business of the Trustee (including any trust created by this Indenture), shall be the successor to the 

  
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Trustee hereunder without the execution or filing of any paper or any further act on the part of any of the parties hereto, provided that in the case of any corporation succeeding to all or
substantially all of the corporate trust business of the Trustee, such corporation shall be qualified under the provisions of Section 11.09 and eligible under the provisions of Section 11.10. 

In case at the time such successor to the Trustee shall succeed to the trusts created by this Indenture, any of the Notes shall have been
authenticated but not delivered, any such successor to the Trustee may adopt the certificate of authentication of any predecessor trustee or authenticating agent appointed by such predecessor trustee, and deliver such Notes so authenticated; and in
case at that time any of the Notes shall not have been authenticated, any successor to the Trustee or any authenticating agent appointed by such successor trustee may authenticate such Notes in the name of the successor trustee; and in all such
cases such certificates shall have the full force that is provided in the Notes or in this Indenture; provided, however, that the right to adopt the certificate of authentication of any predecessor Trustee or authenticate Notes in the name of any
predecessor Trustee shall apply only to its successor or successors by merger, exchange or consolidation. 
 Section 11.14
Preferential Collection of Claims. If and when the Trustee shall be or become a creditor of the Issuer (or any other obligor upon the Notes), the Trustee shall be subject to the provisions of the Trust Indenture Act regarding the collection
of the claims against the Issuer (or any such other obligor). 
 Section 11.15 Trustee’s Application for
Instructions from the Issuer. Any application by the Trustee for written instructions from the Issuer (other than with regard to any action proposed to be taken or omitted to be taken by the Trustee that affects the rights of the Holders of the
Notes under this Indenture) may, at the option of the Trustee, set forth in writing any action proposed to be taken or omitted by the Trustee under this Indenture and the date on and/or after which such action shall be taken or such omission shall
be effective. The Trustee shall not be liable for any action taken by, or omission of, the Trustee in accordance with a proposal included in such application on or after the date specified in such application (which date shall not be less than three
(3) Business Days after the date any officer of the Issuer actually receives such application, unless any such officer shall have consented in writing to any earlier date) unless prior to taking any such action (or the effective date in the
case of an omission), the Trustee shall have received written instructions in response to such application specifying the action to be taken or omitted. 
 ARTICLE 12. 
 HOLDERS’ LISTS AND REPORTS BY TRUSTEE 

Section 12.01 Company to Furnish Trustee Names and Addresses of Holders. The Issuer will furnish or cause to be furnished to
the Trustee: 
 (a) semiannually, not more than 15 days after each Regular Record Date, a list, in such form as
the Trustee may reasonably require, of the names and addresses of the Holders as of such Regular Record Date; and 
 (b) at such other times as the Trustee may request in writing, within 30 days after the receipt by the Issuer of any such request, a list of similar form and content as of a date not more than 15 days
prior to the time such list is furnished; 
 excluding from any such list names and addresses received by the Trustee in its capacity as
Registrar; provided, however, that no such list need be furnished so long as the Trustee is acting as Registrar. 

Section 12.02 Preservation of Information; Communications to Holders. 

(a) The Trustee shall preserve, in as current a form as is reasonably practicable, the names and addresses of Holders
contained in the most recent list furnished to the Trustee as provided in Section 12.01 and the names and addresses of Holders received by the Trustee in its capacity as Registrar. The Trustee may destroy any list furnished to it as provided in
Section 12.01 upon receipt of a new list so furnished. 

  
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 (b) The rights of Holders to communicate with other Holders with respect to
their rights under this Indenture or under the Notes, and the corresponding rights and duties of the Trustee, shall be as provided under applicable law. 
 (c) Every Holder, by receiving and holding the same, agrees with the Issuer and the Trustee that neither the Issuer nor the Trustee nor any agent of either of them shall be held accountable by reason of
any disclosure of information as to names and addresses of Holders made pursuant to applicable law. 
 Section 12.03
Reports By Trustee. The Trustee shall transmit to Holders such reports concerning the Trustee and its actions under this Indenture as may be required pursuant to this Indenture at the times and in the manner provided pursuant thereto. If
required by Section 313 (a) of the Trust Indenture Act, the Trustee shall, within sixty (60) days after each November 15 following the date of the initial issuance of Notes under this Indenture deliver to Holders a brief report,
dated as of such November 15, which complies with the provisions of such Section 313(a). 
 (a) A copy
of each such report shall, at the time of such transmission to Holders, be filed by the Trustee with each stock exchange, if any, upon which the Notes are listed, with the Commission and with the Issuer. The Issuer will notify the Trustee in writing
when the Notes are listed on any stock exchange or of any delisting thereof. 
 ARTICLE 13. 

SATISFACTION AND DISCHARGE 
 Section 13.01 Discharge of Liability on Notes. When (a)(i) the Issuer delivers to the Registrar all outstanding Notes (other than Notes replaced pursuant to Section 3.09) for
cancellation or (ii) all outstanding Notes have become due and payable, whether on the Maturity Date, any Fundamental Change Repurchase Date or Repurchase Date, upon exchange, redemption, declaration of acceleration or otherwise, and the Issuer
irrevocably deposits with the Trustee or delivers to the Holders, as applicable, cash and/or ADSs (solely to satisfy any outstanding Exchange Obligation with respect to the Notes), sufficient to pay or deliver, as the case may be, all amounts due
and owing on all outstanding Notes (other than Notes replaced pursuant to Section 3.09), (b) the Issuer pays all other sums payable by it under this Indenture and (c) the Issuer delivers to the Trustee an Officer’s Certificate
and Opinion of Counsel stating that the conditions precedent therefor have been satisfied, then, this Indenture will cease to be of further effect with respect to the Notes and the Holders and the Trustee will acknowledge the satisfaction and
discharge of this Indenture with respect to the Notes; provided, however, that Sections 3.01, 3.13, 3.14, 4.01, 4.02, 4.04, 4.14, 4.16, 7.03, 7.06, 7.07, 7.09, 8.09 and 8.10 and Articles 13 and 15 hereof will survive any discharge of
this Indenture until such time as the Notes have been paid in full and there are no Notes outstanding; provided, further, that any obligation of the Issuer to the Trustee under Sections 11.06 or 11.07 shall survive after the Notes are paid in
full and there are no Notes outstanding. 
 Section 13.02 Deposited Moneys to Be Held in Trust. Subject to
Section 13.04 hereof, all cash and/or ADSs, if any, deposited with the Trustee pursuant to Section 13.01 hereof will be held in trust for the sole benefit of the Holders, and such cash and/or ADSs, if any, will be applied by the Trustee,
either directly or through the Paying Agent, to the payment of the obligation for which such cash and ADSs, if any, have been deposited with the Trustee. 
 Section 13.03 Paying Agent to Repay Monies Held. Upon the satisfaction and discharge of this Indenture, all cash and ADSs, if any, then held by the Paying Agent (if other than the Trustee)
shall, upon written request of the Issuer, be repaid to it or paid to the Trustee, and thereupon such Paying Agent shall be released from all further liability with respect to such monies and ADSs, if any. 

Section 13.04 Repayment to the Issuer. Subject to any applicable unclaimed property law, the Trustee and the Paying Agent,
upon receiving a written request from the Issuer, will promptly turn over to the Issuer any cash or ADSs held for payment on the Notes that remains unclaimed two years after the date on which such payment was due. After the Trustee and the Paying
Agent return such cash and ADSs, the Trustee and the Paying Agent will have no further liability to any Holder with respect to such cash and ADSs, and any Holder entitled to the payment of such cash or ADSs under the Notes or this Indenture must
look to the Issuer for payment as general creditor of the Issuer. 

  
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 Section 13.05 Reinstatement. If the Trustee or the Paying Agent is unable to
apply any cash or ADSs in accordance with Section 13.02 hereof by reason of any order or judgment of any court or governmental authority enjoining, restraining or otherwise prohibiting such application, the Issuer’s obligations under this
Indenture and the Notes shall be revived and reinstated as though no deposit had occurred pursuant to Section 13.01 until such time as the Trustee or the Paying Agent is permitted to apply all such cash and ADSs, if any, in accordance with
Section 13.02 hereof; provided, however, that if the Issuer makes any payment of the principal of, interest (including Additional Interest, if any) on, Fundamental Change Repurchase Price, Repurchase Price or Redemption Price for,
Additional Amounts with respect to or cash portion of the Exchange Obligation with respect to, any Note following the reinstatement of its obligations, the Issuer shall be subrogated to the rights of the Holders to receive such payment from any cash
and ADSs, if any, held by the Trustee or Paying Agent. 
 ARTICLE 14. 

SUPPLEMENTAL INDENTURES 
 Section 14.01 Without Consent of Holders. The Issuer, the Guarantor and the Trustee may amend or supplement this Indenture or the Notes without the consent of any Holder, to: 

(a) evidence a successor to the Issuer or the Guarantor and the assumption by that successor of the Issuer’s
obligations or the Guarantor’s obligations, as applicable, under the Indenture and under the Notes; 
 (b)
add to the Issuer’s covenants for the benefit of the Holders or surrender any right or power conferred upon the Issuer; 
 (c) secure the Issuer’s obligations in respect of the Notes; 

(d) evidence and provide for the acceptance of the appointment of a successor Trustee in accordance with this Indenture;

 (e) cure any ambiguity, omission, inconsistency or correct or supplement any defective provision contained in
this Indenture; 
 (f) to add guarantees with respect to the Notes; 

(g) to provide for a successor trustee; 

(h) make any change that does not adversely affect the interests of the Holders; or 

(i) conform the provisions of this Indenture to the “Description of notes” section of the Offering Memorandum,
as set forth in an Officer’s Certificate. 
 In addition, without the consent of any Holder, the Guarantor, or its
Subsidiary, may directly assume this Indenture and the Notes as set forth in Section 10.03. 
 Section 14.02 With
Consent of Holders. With the written consent of the Holders of at least a majority in principal amount of then outstanding Notes (including, without limitation, consents obtained in connection with a repurchase of, or tender offer or exchange
offer for, the Notes), and, subject to the exceptions provided in Section 9.02(c) hereof, any past Default or compliance with any provisions waived with the written consent of the Holders of a majority in principal amount of then outstanding
Notes (including, without limitation, consents obtained in connection with a repurchase of, or tender offer or exchange offer for, the Notes); provided, however, that, without the consent of each Holder of a then outstanding Note affected, no
amendment or supplement to this Indenture or the Notes may: 
 (a) alter the manner of calculation or rate of
accrual of interest on any Note or change the time of payment of any installment of interest on any Note; 

  
 88 

 (b) make any of the Notes payable in money or securities other than that
stated in the Note; 
 (c) change the Maturity Date of any Note; 

(d) reduce the principal amount, Redemption Price, Fundamental Change Repurchase Price or Repurchase Price with respect
to any of the Notes; 
 (e) make any change that adversely affects the rights of Holders to require the Issuer
to repurchase the Notes at the option of the Holders upon a Fundamental Change or upon the exercise of the Optional Put rights; 
 (f) impair the right to institute suit for the enforcement of any payment on or with respect to any Note or with respect to the exchange of any Note; 

(g) adversely affect the exchange rights of the Notes, including by modification to any of the notice provisions;

 (h) change the percentage in aggregate principal amount of then outstanding Notes necessary to modify or
amend the Indenture or to waive any past Default or Event of Default; 
 (i) change the ranking of the Notes or
the Guarantee; 
 (j) change the Issuer’s obligations under Section 4.16; 

(k) [Reserved.]; 
 (l) make any change in the provisions of this Section 14.02 or in the provisions relating to the waiver of particular past Events of Default or particular covenants, except (i) to the extent
permitted under Section 14.02(h) or (ii) to provide that any additional provisions may not be modified or waived without the consent of the Holder of a then outstanding Note affected; or 

(m) release the Guarantor from, or modify or affect in any manner adverse to the Holders the terms and conditions of, the
obligations of the Guarantor under the Guarantee. 
 It will not be necessary for the consent of the Holders under this
Section 14.02 to approve the particular form of any proposed amendment, but it will be sufficient if such consent approves the substance of such proposed amendment. 
 Section 14.03 Notices of Supplemental Indentures. After an amendment or supplement to this Indenture or the Notes pursuant to this Article 14 becomes effective, the Issuer will mail to
the Holders a notice briefly describing such amendment or supplement to this Indenture. However, the failure to give such notice to all Holders, or any defect in such notice, will not impair or affect the validity of such amendment or supplement to
this Indenture. 
 Section 14.04 Execution of Supplemental Indentures. In executing, or accepting the additional
trusts created by, any supplemental indenture permitted by this Article or the modification thereby of the trusts created by this Indenture, the Trustee shall receive, and shall be fully protected in relying upon, an Officer’s Certificate and
an Opinion of Counsel stating that the execution of such supplemental indenture is authorized or permitted by this Indenture and that such supplemental indenture is the legal, valid and binding obligation of the Issuer, enforceable against the
Issuer in accordance with its terms. The Trustee may, but shall not be obligated to, enter into any such supplemental indenture which affects the Trustee’s own rights, duties or immunities under this Indenture or otherwise. 

  
 89 

 ARTICLE 15. 
 GUARANTEE 
 Section 15.01 Guarantee. By its execution hereof, the
Guarantor acknowledges and agrees that it receives substantial benefits from the Issuer and the issuance of the Notes and that the Guarantor is providing its Guarantee for good and valuable consideration, including, without limitation, such
substantial benefits. Accordingly, subject to the provisions of this Article 15, the Guarantor hereby unconditionally guarantees to each Holder and its successors and assigns that: (x) the principal of (including the Redemption Price,
Fundamental Change Repurchase Price and Repurchase Price), Additional Amounts with respect to, Exchange Obligation with respect to, and interest and Additional Interest, if any, on the Notes shall be duly and punctually paid in full and/or performed
in accordance with the terms of this Indenture when due, whether at the Maturity Date, upon declaration of acceleration, upon redemption, upon required repurchase, upon exchange or otherwise, and interest on overdue principal, interest, Additional
Amounts and (to the extent permitted by law) interest on any interest, if any, on the Notes and (y) in case of any extension of time of payment or renewal of any Notes or any of such other obligations, the same shall be promptly paid in full
when due or performed in accordance with the terms of the extension or renewal, whether at the Maturity Date, by acceleration, redemption, required repurchase, exchange or otherwise. Furthermore, subject to the provisions of this Article 15, the
Guarantor hereby unconditionally guarantees to the Trustee and to each Holder and their respective successors and assigns that (z) all other obligations of the Issuer to the Holders or the Trustee hereunder or under the Notes (including fees,
expenses or other) shall be promptly paid in full or performed, all in accordance with the terms hereof, subject, however, in the case of clauses (x), (y) and (z) above, to the limitations set forth in Section 15.03 hereof (the
obligations set forth in this Section 15.01 collectively, the “Guarantee Obligations”). The Guarantee constitutes a general unsecured and unsubordinated obligation of the Guarantor. 

Subject to the provisions of this Article 15, the Guarantor hereby agrees that its Guarantee hereunder shall be unconditional,
irrespective of the validity, regularity or enforceability of the Notes or this Indenture, the absence of any action to enforce the same, any waiver or consent by any Holder of the Notes with respect to any thereof, the entry of any judgment against
the Issuer, any action to enforce the same or any other circumstance which might otherwise constitute a legal or equitable discharge or defense of the Guarantor. The Guarantor hereby waives and relinquishes: (a) any right to require the
Trustee, the Holders or the Issuer (each, a “Benefited Party”) to proceed against the Issuer or any other Person or to proceed against or exhaust any security held by a Benefited Party at any time or to pursue any other remedy in
any secured party’s power before proceeding against the Guarantor; (b) any defense that may arise by reason of the incapacity, lack of authority, death or disability of any other Person or Persons or the failure of a Benefited Party to
file or enforce a claim against the estate (in administration, bankruptcy or any other proceeding) of any other Person or Persons; (c) demand, protest and notice of any kind (except as expressly required by this Indenture), including but not
limited to notice of the existence, creation or incurring of any new or additional indebtedness or obligation or of any action or non-action on the part of the Guarantor, the Issuer, any Benefited Party, any creditor of the Guarantor or the Issuer
or on the part of any other Person whomsoever in connection with any obligations the performance of which are hereby guaranteed; (d) any defense based upon an election of remedies by a Benefited Party, including but not limited to an election
to proceed against the Guarantor for reimbursement; (e) any defense based upon any statute or rule of law which provides that the obligation of a surety must be neither larger in amount nor in other respects more burdensome than that of the
principal; (f) any defense arising because of a Benefited Party’s election, in any proceeding instituted under Bankruptcy Law, of the application of Section 1111(b)(2) of the Bankruptcy Code; and (g) any defense based on any
borrowing or grant of a security interest under Section 364 of the Bankruptcy Code. The Guarantor hereby covenants that, except as otherwise provided therein, the Guarantee shall not be discharged except by payment in full of all Guarantee
Obligations, including the principal, Additional Amounts, Exchange Obligations and interest on the Notes and all other costs provided for under this Indenture or as provided in Article 11. 

The Guarantor as principal obligor and as a separate and independent obligation and liability from its other obligations and liabilities
under this Indenture agrees to indemnify and keep indemnified each Holder and the Trustee in full and on demand in respect of the performance and discharge of the Guarantee Obligations (except where the Issuer’s failure to perform or discharge
the Guarantee Obligations results from such Holder’s failure to comply with its obligations under the Indenture or the Trustee’s negligence or willful misconduct or the Issuer contesting any payment or part of a payment in good faith).

  
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 If any Holder or the Trustee is required by any court or otherwise to return to either the
Issuer or the Guarantor, or any trustee or similar official acting in relation to either the Issuer or the Guarantor, any amount paid by the Issuer or the Guarantor to the Trustee or such Holder, then the Guarantee, to the extent theretofore
discharged, shall be reinstated in full force and effect. The Guarantor agrees that it shall not be entitled to any right of subrogation in relation to the Holders in respect of any Guarantee Obligations hereby until payment in full of all such
obligations guaranteed hereby. The Guarantor agrees that, as between it, on the one hand, and the Holders and the Trustee, on the other hand, (x) the maturity of the obligations guaranteed hereby may be accelerated as provided in Article 9
hereof for the purposes hereof, notwithstanding any stay, injunction or other prohibition preventing such acceleration in respect of the Guarantee Obligations, and (y) in the event of any acceleration of such obligations as provided in
Article 9 hereof, such Guarantee Obligations (whether or not due and payable) shall forthwith become due and payable by the Guarantor for the purpose of the Guarantee. 
 The Issuer and the Guarantor acknowledge that the allotment and issue of Ordinary Shares and the delivery of ADSs, if any, hereunder (whether upon exchange, under the terms of the Guarantee or otherwise)
by the Guarantor (or by the ADS Depositary at the direction of the Guarantor) to, or at the direction of, the Issuer will create an equivalent debt owing from the Issuer to the Guarantor. 

Section 15.02 Execution and Delivery of Guarantee. To evidence the Guarantee set forth in Section 15.01 hereof, the
Guarantor agrees that a notation of the Guarantee substantially in the form thereof included in Section 2.03 hereto shall be endorsed on each Note authenticated and delivered by the Trustee and that this Indenture shall be executed on behalf of
the Guarantor by an officer of the Guarantor. 
 The Guarantor agrees that the Guarantee set forth in this Article 15 shall
remain in full force and effect and apply to all the Notes notwithstanding any failure to endorse on each Note a notation of the Guarantee. 
 If an officer whose facsimile signature is on a Note or a notation of Guarantee no longer holds that office at the time the Trustee authenticates the Note on which the Guarantee is endorsed, the Guarantee
shall be valid nevertheless. 
 The delivery of any Note by the Trustee, after the authentication thereof hereunder, shall
constitute due delivery of the Guarantee set forth in this Indenture on behalf of the Guarantor. 
 Section 15.03
Limitation of Guarantor’s Liability; Certain Bankruptcy Events. 
 (a) The Guarantor, and by its
acceptance hereof each Holder, hereby confirms that it is the intention of all such parties that the Guarantee Obligations of the Guarantor pursuant to its Guarantee not constitute a fraudulent transfer or conveyance for purposes of any Bankruptcy
Law, the Uniform Fraudulent Conveyance Act, the Uniform Fraudulent Transfer Act or any similar federal or state law. To effectuate the foregoing intention, the Holders and the Guarantor hereby irrevocably agree that the Guarantee Obligations of the
Guarantor under this Article 15 shall be limited to the maximum amount as shall, after giving effect to all other contingent and fixed liabilities of the Guarantor, result in the Guarantee Obligations of the Guarantor under the Guarantee not
constituting a fraudulent transfer or conveyance. 
 (b) The Guarantor hereby covenants and agrees, to the
fullest extent that it may do so under applicable law, that in the event of the insolvency, bankruptcy, dissolution, liquidation or reorganization of the Issuer, the Guarantor shall not file (or join in any filing of), or otherwise seek to
participate in the filing of, any motion or request seeking to stay or to prohibit (even temporarily) execution on the Guarantee and hereby waives and agrees not to take the benefit of any such stay of execution, whether under Section 362 or
105 of the Bankruptcy Code or otherwise. 
 Section 15.04 Application of Certain Terms and Provisions to the
Guarantor. 
 (a) For purposes of any provision of this Indenture which provides for the delivery by the
Guarantor of an Officer’s Certificate and/or an Opinion of Counsel, the definitions of such terms in Section 1.01 hereof shall apply to the Guarantor as if references therein to the Issuer or the Guarantor, as applicable, were references
to the Guarantor. 

  
 91 

 (b) Any request, direction, order or demand which by any provision of this
Indenture is to be made by the Guarantor shall be sufficient if evidenced as described in Section 16.02 hereof as if references therein to the Issuer were references to the Guarantor. 

(c) Upon any demand, request or application by the Guarantor to the Trustee to take any action under this Indenture, the
Guarantor shall furnish to the Trustee such certificates and opinions as are required in Section 16.04 hereof as if all references therein to the Issuer were references to the Guarantor. 

ARTICLE 16. 

MISCELLANEOUS 

Section 16.01 Official Acts by Successor Corporation. Any act or proceeding by any provision of this Indenture authorized or
required to be done or performed by any board, committee or officer of the Issuer shall and may be done and performed with like force and effect by the like board, committee or officer of any Person that shall at the time be the lawful sole
successor of the Issuer or Guarantor. 
 Section 16.02 Notices. Any notice or communication shall be in writing
(including telecopy promptly confirmed in writing) and delivered in person or mailed by first-class mail addressed as follows: 
 if to the Issuer: 
 Corsicanto Limited 

Arthur Cox Building 
 Earlsfort Terrace 
 Dublin 2, Ireland 

Fax +353 1 618 0618 
 with a copy to: 
 Amarin Corporation plc 

2 Pembroke House 
 Upper Pembroke Street 28-32 
 Dublin 2, Ireland 

Goodwin Procter LLP 
 53 State Street 
 Boston, MA 02109 

Attention: Michael Bison and James Barri 

if to Guarantor: 
 Amarin Corporation plc 
 2 Pembroke House 

Upper Pembroke Street 28-32 
 Dublin 2, Ireland 
 with a copy to: 

Goodwin Procter LLP 
 53 State Street 
 Boston, MA 02109 

Attention: Michael Bison and James Barri 

  
 92 

 if to the Trustee: 

Wells Fargo Bank, National Association 

Corporate Trust Services 
 MAC N9311-110 
 625Marquette Ave. South 

Minneapolis, MN 55479 
 Attention: Corsicanto Ltd. Account Manager 
 Facsimile:
612-667-9825 
 The Issuer, the Guarantor or the Trustee by notice to the others may designate additional or different addresses
for subsequent notices or communications. 
 Any notice or communication mailed to a registered Holder shall be mailed to the
Holder at the Holder’s address as it appears on the registration books of the Registrar and shall be sufficiently given if so mailed within the time prescribed. 
 Failure to mail a notice or communication to a Holder or any defect in it shall not affect its sufficiency with respect to other Holders. If a notice or communication is mailed in the manner provided
above, it is duly given, whether or not the addressee receives it, except that notices to the Trustee shall be effective only upon receipt. 
 The Trustee agrees to accept and act upon facsimile transmission of written instructions and/or directions pursuant to this Indenture given by the Issuer, provided, however, that (i) the Issuer,
subsequent to such facsimile transmission of written instructions and/or directions, shall provide the originally executed instructions and/or directions to the Trustee in a timely manner and (ii) such originally executed instructions and/or
directions shall be signed by an authorized officer of the Issuer. 
 Section 16.03 Official Acts by Successor
Corporation. Any act or proceeding by any provision of this Indenture authorized or required to be done or performed by any board, committee or officer of the Issuer shall and may be done and performed with like force and effect by the like
board, committee or officer of any Person that shall at the time be the lawful sole successor of the Issuer or Guarantor. 

Section 16.04 Certificate and Opinion as to Conditions Precedent. Upon any request or application by the Issuer to the
Trustee to take or refrain from taking any action under this Indenture, the Issuer shall furnish to the Trustee: 
 (a) an Officer’s Certificate in form and substance reasonably satisfactory to the Trustee stating that, in the opinion of the signers, all conditions precedent, if any, provided for in this Indenture
relating to the proposed action have been complied with; and 
 (b) an Opinion of Counsel in form and substance
reasonably satisfactory to the Trustee stating that, in the opinion of such counsel, all such conditions precedent have been complied with. 
 Section 16.05 When Notes Are Disregarded. In determining whether the Holders of the required principal amount of Notes have concurred in any direction, waiver or consent, Notes owned by the
Issuer or by any Affiliate of the Issuer shall be disregarded and deemed not to be outstanding, except that, for the purpose of determining whether the Trustee shall be protected in relying on any such direction, waiver or consent, only Notes which
a Trust Officer of the Trustee actually knows are so owned shall be so disregarded. Also, subject to the foregoing, only Notes outstanding at the time shall be considered in any such determination. 

Section 16.06 Rules by Trustee, Paying Agent and Registrar. The Trustee may make reasonable rules for action by, or a
meeting of, Holders. The Registrar and the Paying Agent may make reasonable rules for their functions. 

  
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 Section 16.07 Legal Holidays. If an Interest Payment Date is a Legal Holiday,
payment shall be made on the next succeeding day that is not a Legal Holiday, and no interest shall accrue for the intervening period. If a Regular Record Date is a Legal Holiday, the Regular Record Date shall not be affected. In any case where the
Maturity Date, Fundamental Change Purchase Date, Repurchase Date or Redemption Date, as the case may be, of any Note is a Legal Holiday, then (notwithstanding any other provision of this Indenture or of the Notes) payment of principal need not be
made on such date, but may be made on the next succeeding day that is not a Legal Holiday, with the same force and effect as if made on such Maturity Date, Fundamental Change Purchase Date, Repurchase Date or Redemption Date, as the case may be.

 Section 16.08 Governing Law. THIS INDENTURE AND THE NOTES, AND ANY CLAIM, CONTROVERSY OR DISPUTE ARISING UNDER
OR RELATED TO THIS INDENTURE OR THE NOTES, SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF NEW YORK (WITHOUT REGARD TO THE CONFLICTS OF LAWS PROVISIONS THEREOF). 

Section 16.09 No Recourse against Others. Except to the extent provided otherwise herein, an incorporator, director,
officer, employee, Affiliate or shareholder of the Issuer or the Guarantor, solely by reason of this status, shall not have any liability for any obligations of the Issuer or the Guarantor under the Notes, this Indenture or for any claim based on,
in respect of or by reason of such obligations or their creation. By accepting a Note, each Holder shall waive and release all such liability. The waiver and release shall be part of the consideration for the issue of the Notes. 

Section 16.10 Successors. All the covenants, stipulations, promises and agreements by the Issuer or Guarantor contained in
this Indenture shall bind their respective successors and assigns whether so expressed or not. 
 Section 16.11
Multiple Originals. The parties may sign any number of copies of this Indenture. Each signed copy shall be an original, but all of them together represent the same agreement. One signed copy is enough to prove this Indenture. Delivery of an
executed counterpart by facsimile shall be effective as delivery of a manually executed counterpart thereof. 

Section 16.12 Benefits of Indenture. Nothing in this Indenture or in the Notes, express or implied, shall give to any
Person, other than the parties hereto and their respective successors hereunder and the Holders of Notes, any benefit or any legal or equitable right, remedy or claim under this Indenture. 

Section 16.13 Table of Contents; Headings. The table of contents, cross-reference sheet and headings of the Articles and
Sections of this Indenture have been inserted for convenience of reference only, are not intended to be considered a part hereof and shall not modify or restrict any of the terms or provisions hereof. 

Section 16.14 Severability Clause. In case any provision in this Indenture shall be invalid, illegal or unenforceable, the
validity, legality and enforceability of the remaining provisions shall not in any way be affected or impaired thereby and such provision shall be ineffective only to the extent of such invalidity, illegality or unenforceability. 

Section 16.15 Calculations. Except as otherwise provided herein, the Issuer will be responsible for making all calculations
called for under this Indenture or the Notes (including, without limitation, determinations of the Last Reported Sale Prices of the ADSs, accrued interest payable on the Notes, the Trading Price of the Notes and the Exchange Rate of the Notes). The
Issuer will make all such calculations in good faith and, absent manifest error, its calculations will be final and binding on Holders. The Issuer will provide a schedule of its calculations to each of the Trustee and the Exchange Agent, and each of
the Trustee and Exchange Agent is entitled to rely conclusively upon the accuracy of such calculations without independent verification. The Trustee will deliver a copy of such schedule to any Holder upon the written request of such Holder.

 Section 16.16 Waiver of Jury Trial. EACH OF THE ISSUER, THE GUARANTOR AND THE TRUSTEE HEREBY IRREVOCABLY WAIVES,
TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF OR RELATING TO THIS AGREEMENT, THE SECURITIES OR THE TRANSACTION CONTEMPLATED THEREBY. 

  
 94 

 Section 16.17 Consent to Jurisdiction. 

(a) Each of the Issuer and the Guarantor hereby irrevocably and unconditionally submits, for itself and its property, to
the nonexclusive jurisdiction of any New York State court or federal court of the United States sitting in the State and City of New York, County and Borough of Manhattan, and any appellate court from any thereof, in any action or proceeding arising
out of or relating to this Indenture or the Notes, or for recognition or enforcement of any judgment, and each of the parties hereto hereby irrevocably and unconditionally agrees that all claims in respect of any such action or proceeding may be
heard and determined in such state court sitting in the State and City of New York, County and Borough of Manhattan or, to the extent permitted by law, in such federal court sitting in the State and City of New York, County and Borough of Manhattan.

 (b) Each of the Issuer and the Guarantor hereby irrevocably and unconditionally waives, to the fullest extent
it may legally and effectively do so, any objection which it may now or hereafter have to the laying of venue of any suit, action proceeding arising out of or relating to this Indenture or the Notes in any New York State or federal court. Each of
the parties hereto hereby irrevocably waives, to the fullest extent permitted by law, the defense of an inconvenient forum to the maintenance of such action or proceeding in any such court. 

Section 16.18 Force Majeure. In no event shall the Trustee be responsible or liable for any failure or delay in the
performance of its obligations hereunder arising out of or caused by, directly or indirectly, forces beyond its control, including, without limitation, strikes, work stoppages, accidents, acts of war or terrorism, civil or military disturbances,
nuclear or natural catastrophes or acts of God, and interruptions, loss or malfunctions of utilities, communications or computer (software or hardware) services; it being understood that the Trustee shall use reasonable efforts which are consistent
with accepted practices in the banking industry to resume performance as soon as practicable under the circumstances. 

Section 16.19 U.S.A. Patriot Act. The parties hereto acknowledge that in accordance with Section 326 of the U.S.A.
Patriot Act, the Trustee, like all financial institutions and in order to help fight the funding of terrorism and money laundering, is required to obtain, verify, and record information that identifies each person or legal entity that establishes a
relationship or opens an account with the Trustee. The parties to this Indenture agree that they will provide the Trustee with such information as it may request in order for the Trustee to satisfy the requirements of the U.S.A. Patriot Act.

 [Remainder of the page intentionally left blank] 

  
 95 

 IN WITNESS WHEREOF, the parties hereto have caused this Indenture to be duly executed as of
the day and year first above written. 
  

							
	 SIGNED AND DELIVERED for and on
 behalf of and as the deed of CORSICANTO
 LIMITED by its lawfully appointed
attorney
 PATRICK JOSEPH O’SULLIVAN in the
 presence of:
	 		 	 /s/ Patrick Joseph O’Sullivan

		 		 	PATRICK JOSEPH O’SULLIVAN
			
	 /s/ Brendan Wallace
	 		 	
	(Witness’ Signature)	 		 	
			
	Brendan Wallace	 		 	
			
	Arthur Cox Building, Earlsfort Terrace	 		 	
			
	Dublin 2, Ireland	 		 	
	(Witness’s Address)	 		 	
			
	Solicitor	 		 	
	(Witness’ Occupation)	 		 	
			
	 SIGNED AS A DEED by AMARIN 
 CORPORATION PLC as Guarantor acting
 by Mr. JOSEPH S. ZAKRZEWSKI,
a
 director and Executive Chairman, in the
 presence of:
	 		 	 /s/ Joseph S. Zakrzewski

							
			
	Witness:	 		 	
				
	Signature:	 	 /s/ Joseph T. Kennedy
	 		 	

							
				
	Name:	 	 Joseph T. Kennedy
	 		 	

							
				
	Address:	 	  
	 		 	
				
		 	  
	 		 	

 [Trustee Signature Follows] 

  
 96 

 
			
	WELLS FARGO BANK, NATIONAL ASSOCIATION
	as Trustee
		
	By:	 	 /s/ Lynn M. Steiner

	Name: Lynn M. Steiner
	Title: Vice President

  
 97 

 EXHIBIT A 
 [FORM OF RESTRICTED STOCK LEGEND] 
 THE SALE OF THIS SECURITY HAS NOT BEEN
REGISTERED UNDER THE U.S. SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, THIS SECURITY (AND ANY BENEFICIAL INTEREST HEREIN) MAY NOT BE OFFERED, RESOLD, PLEDGED OR OTHERWISE TRANSFERRED, EXCEPT IN ACCORDANCE
WITH THE FOLLOWING SENTENCE. BY ITS ACQUISITION HEREOF OR A BENEFICIAL INTEREST HEREIN, THE ACQUIRER: 
  

	 	(1)	REPRESENTS THAT IT AND ANY ACCOUNT FOR WHICH IT IS ACTING IS A “QUALIFIED INSTITUTIONAL BUYER” (WITHIN THE MEANING OF RULE 144A UNDER THE SECURITIES ACT)
AND THAT IT EXERCISES SOLE INVESTMENT DISCRETION WITH RESPECT TO EACH SUCH ACCOUNT; AND 

  

	 	(2)	AGREES FOR THE BENEFIT OF THE COMPANY THAT IT WILL NOT OFFER, SELL, PLEDGE OR OTHERWISE TRANSFER THIS SECURITY OR ANY BENEFICIAL INTEREST HEREIN PRIOR TO THE RESALE
RESTRICTION TERMINATION DATE (AS DEFINED BELOW), EXCEPT: 

  

	 	(A)	TO THE COMPANY OR ANY SUBSIDIARY THEREOF; 

  

	 	(B)	PURSUANT TO A REGISTRATION STATEMENT THAT HAS BECOME EFFECTIVE UNDER THE SECURITIES ACT; 

 

	 	(C)	TO A PERSON THAT YOU REASONABLY BELIEVE TO BE A QUALIFIED INSTITUTIONAL BUYER IN COMPLIANCE WITH RULE 144A UNDER THE SECURITIES ACT; OR 

 

	 	(D)	UNDER ANY OTHER AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT (INCLUDING, IF AVAILABLE, THE EXEMPTION PROVIDED BY REGULATION S AND
RULE 144 UNDER THE SECURITIES ACT). 

 THE “RESALE RESTRICTION TERMINATION DATE” MEANS THE DATE
THAT IS THE LATER OF: (X) TWELVE MONTHS AFTER THE LAST ORIGINAL ISSUANCE DATE OF THE COMPANY’S SUBSIDIARY’S 3.50% EXCHANGEABLE SENIOR NOTES DUE 2032 (THE “NOTES”) (INCLUDING THE LAST DATE OF ISSUANCE OF ADDITIONAL NOTES
PURSUANT TO THE EXERCISE OF THE INITIAL PURCHASERS’ OPTION TO PURCHASE ADDITIONAL NOTES) OR SUCH SHORTER PERIOD OF TIME AS PERMITTED BY RULE 144 UNDER THE SECURITIES ACT OR ANY SUCCESSOR PROVISION THERETO; AND (Y) SUCH LATER DATE, IF ANY,
AS MAY BE REQUIRED BY APPLICABLE LAW. PRIOR TO ANY TRANSFER PURSUANT TO THE FOREGOING CLAUSE (2)(D), THE COMPANY, THE ISSUER OF THE NOTES AND THE DEPOSITARY FOR THE COMPANY’S AMERICAN DEPOSITARY SHARES RESERVE THE RIGHT TO REQUIRE THE DELIVERY
OF SUCH CERTIFICATIONS, LEGAL OPINIONS OR OTHER INFORMATION AS THEY MAY REASONABLY REQUIRE AND MAY RELY UPON TO CONFIRM THAT SUCH TRANSFER IS BEING MADE PURSUANT TO AN EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS
OF THE SECURITIES ACT. 

  
 A-1

 EXHIBIT B 
 [FORM OF FREE TRANSFERABILITY CERTIFICATE] 
 Officer’s Certificate

 [NAME OF OFFICER], the [TITLE] of Corsicanto Limited, a limited liability of company incorporated under the laws of
Ireland (the “Company”) does hereby certify, in connection with the sale of $[150,000,000] of the Issuer’s 3.50% Exchangeable Senior Notes due 2032 (the “Notes”) pursuant to the terms of the Indenture, dated as
of January 9, 2012 (as may be amended or supplemented from time to time, the “Indenture”), by and among the Issuer, Amarin Corporation plc (the “Guarantor”) and Wells Fargo Bank, National Association (the
“Trustee”), that: 
 1. The undersigned is permitted to sign this “Officer’s Certificate” on
behalf of the Issuer, as the term “Officer’s Certificate” is defined in the Indenture. 
 2. The undersigned has
read, and thoroughly examined, the Indenture and the definitions therein relating thereto. 
 3. In the opinion of the
undersigned, the undersigned has made such examination as is necessary to enable the undersigned to express an informed opinion as to whether or not all conditions precedent to the removal of the Restricted Notes Legend described herein as provided
for in the Indenture have been complied with. 
 4. To the best knowledge of the undersigned, all conditions precedent described
herein as provided for in the Indenture have been complied with. 
 In accordance with Section 3.08 of the Indenture, the
Issuer hereby instructs you as follows: 
 1. To take those actions necessary so that the Restricted Notes Legend and set forth
on the Restricted Global Notes shall be deemed removed from the Global Notes in accordance with the terms and conditions of the Notes and as provided in the Indenture, without further action on the part of the Holders. 

2. To take those actions necessary so that the restricted CUSIP number for the Notes shall be removed from the Global Notes and replaced
with an unrestricted CUSIP number, which unrestricted CUSIP number shall be [            ], in accordance with the terms and conditions of the Global Notes and as provided in the Indenture,
without further action on the part of the Holders. 
 [Signature page follows.] 

  
 B-1

 IN WITNESS WHEREOF, we have signed this certificate as of
[                    ]. 
  

			
	CORSICANTO LIMITED,
		
	By:	 	  

	Name:	 	
	Title:	 	

  
 B-2

 EXHIBIT C 
 [FORM OF NOTICE OF TAX REDEMPTION ELECTION] 
 To: [    ] 

The undersigned registered owner of this Note hereby elects to not have this Note, or the portion hereof (that is $200,000 principal
amount or an integral multiple of $1,000 in excess thereof) below designated, be subject to a Tax Redemption, and any Notes representing any principal amount hereof not subject to such Tax Redemption, be issued and delivered to the registered holder
hereof unless a different name has been indicated below. If any portion of this Note not subject to such Tax Redemption is to be issued in the name of a Person other than the undersigned, the undersigned will pay all transfer taxes payable with
respect thereto. 
 The undersigned hereby certifies that it (or if it is acting for the account of one or more persons, that
each such person) is not, and has not been, during the ninety days immediately preceding the date hereof, an “affiliate” of the Issuer or of the Guarantor (within the meaning of Rule 144 under the Securities Act of 1933, as amended).

  

					
	Dated:                     	 		 	  

		 		 	  

		 		 	Signature(s)
			
	  
	 		 	
	Signature Guarantee	 		 	
			
	Signature(s) must be guaranteed by an eligible Guarantor Institution (banks, stock brokers, savings and loan associations and credit unions) with membership in an approved signature
guarantee medallion program pursuant to Securities and Exchange Commission Rule 17Ad-15 if Ordinary Shares are to be issued, or Notes to be delivered, other than to and in the name of the registered holder.	 		 	

  
 C-1

					
	Fill in for registration of Notes to be delivered, other than to and in the name of the registered holder:	 		 	
			
	  
	 		 	
	(Name)	 		 	
			
	  
	 		 	
	(Street Address)	 		 	
			
	  
	 		 	
	(City, State and Zip Code)	 		 	
	Please print name and address	 		 	
		 		 	Principal amount not subject to Tax Redemption (if less than all):
		 		 	$            ,000
			
		 		 	NOTICE: The above signature(s) of the holder(s) hereof must correspond with the name as written upon the face of the Note in every particular without alteration or enlargement or
any change whatever.
			
		 		 	  

		 		 	Social Security or Other Taxpayer Identification Number

  
 C-2

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