Document:

EX-10.4

 Exhibit 10.4 

EMPLOYEE NONCOMPETITION, 

NONDISCLOSURE AND DEVELOPMENTS AGREEMENT 

This Employee Noncompetition, Nondisclosure and Developments Agreement (the “Agreement”) is entered into as of
December 9, 2013 (the “Effective Date”) by and between Paul Estrem the undersigned employee and Melinta Therapeutics, Inc., its parents, affiliates and subsidiaries (the “Company”). 

NOW THEREFORE, in consideration of my employment by the Company and of the covenants herein, my employment with the Company, and for other
good and valuable consideration, I hereby covenant and agree as follows: 
 1. Best Efforts. 

During the period of my employment by the Company, I shall devote my full time and best efforts to the business of the Company, and I shall
neither pursue any business opportunity outside the Company nor take any position with any organization other than the Company without the written approval of the Chief Executive Officer or his or her designee. 

2. Noncompetition. 
 During the period of
my employment by the Company, I shall not, directly or indirectly, alone or as a consultant, partner, officer, director, employee, joint venturer, lender or stockholder of any entity, engage in any business or activity that is in competition with
the products or services being created, developed, manufactured, marketed, distributed or sold by the Company in (a) the State of Connecticut, (b) the States of New York, Massachusetts, Connecticut and Illinois, (c) the continental
United States of America, (d) the United States and Europe or (e) worldwide. For one year following the termination of my employment, regardless of the reasons for my termination, I will refrain from management of or participation in
programs at or on behalf of any entity in areas related to antimicrobials or in areas related to specific chemical approaches or series the Company is engaged in during my employment or in which the Company is planning to engage or has in the past
engaged. In the case of areas of business unrelated to antimicrobials, for one year following the termination of my employment, regardless of the reasons for my termination, I will refrain from management of or participating in any such non-antimicrobial programs which are under prosecution at the Company, in which the Company is planning to engage or has in the past engaged in. 

3. Nonsolicitation of Customers. 
 During
the period of my employment by the Company and for one year following the termination of my employment, regardless of the reasons for my termination, I shall not, directly or indirectly, alone or as a consultant, partner, officer, director,
employee, joint venturer, lender or stockholder of any entity, solicit or do business with any customer of the Company or any potential customer of the Company (i) with whom I have had contact or (ii) about whom I obtained information, or
became familiar with through Confidential Information (as defined in Paragraph 5), during the course of my employment with the Company. 

        PE 11/11/13 

Initial and Date 

 4. Nonsolicitation of Employees. 

(a) During the period of my employment by the Company and for one year following the termination of my employment, regardless of the reasons
for the termination, I will not, in any manner, hire or engage, or assist any company or business organization by which I am employed or which is directly or indirectly controlled by me to hire or engage, any person who is or was employed by the
Company (or is or was an agent, representative, contractor, project consultant or consultant of the Company) at the time of my termination. 

(b) During the period of my employment by the Company and for one year following the termination of my employment, regardless of the reasons
for the termination, I will not, in any manner, solicit, recruit or induce, or assist any company or business organization by which I am employed or which is directly or indirectly controlled by me to solicit, recruit or induce, any person who is or
was employed by the Company (or is or was an agent, representative, contractor, project consultant or consultant of the Company) at the time of my termination, to leave his or her employment, relationship or engagement with the Company. 

5. Nondisclosure. 
 I shall not at any
time, whether during or after the termination of my employment, reveal to any person or entity any Confidential Information except to employees of the Company who need to know such Confidential Information for the purposes of their employment, or as
otherwise authorized by the Company in writing. The term “Confidential Information” shall include any information concerning the organization, business or finances of the Company or of any third party which the Company is under an
obligation to keep confidential that is maintained by the Company as confidential. Such Confidential Information shall include, but is not limited to, trade secrets or confidential information respecting inventions, products, designs, methods, know-how, techniques, systems, processes, specifications, blueprints, engineering data, software programs, works of authorship, customer lists, customer information, financial information, pricing information,
personnel information, business plans, projects, plans and proposals. I shall keep confidential all matters entrusted to me and shall not use or attempt to use any Confidential Information except as may be required in the ordinary course of
performing my duties as an employee of the Company, nor shall I use any Confidential Information in any manner which may injure or cause loss or may be calculated to injure or cause loss to the Company, whether directly or indirectly. 

6. Assignment of Developments. 
 (a) If at
any time or times during my employment, I shall (either alone or with others) make, conceive, create, discover, invent or reduce to practice any Development that (i) relates to the business of the Company or any customer of or supplier to the
Company or any of the products or services being developed, manufactured or sold by the Company or which may be used in relation therewith; or (ii) results from tasks assigned to me by the Company; or (iii) results from the use of premises
or personal property (whether tangible or intangible) owned, leased or contracted for by the Company, then all such Developments and the benefits thereof are 

  
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and shall immediately become the sole and absolute property of the Company and its assigns, as works made for hire or otherwise. The term “Development” shall mean any invention,
modification, discovery, design, development, improvement, process, software program, work of authorship, documentation, formula, data, technique, know-how, trade secret or intellectual property right
whatsoever or any interest therein (whether or not patentable or registrable under copyright, trademark or similar statutes (including, but not limited to, the Semiconductor Chip Protection Act) or subject to analogous protection). I shall promptly
disclose to the Company (or any persons designated by it) each such Development. I hereby assign all rights (including, but not limited to, rights to inventions, patentable subject matter, copyrights and trademarks) I may have or may acquire in the
Developments and all benefits and/or rights resulting therefrom to the Company and its assigns without further compensation and shall communicate, without cost or delay, and without disclosing to others the same, all available information relating
thereto (with all necessary plans and models) to the Company. 
 (b) Excluded Developments. I represent that the Developments
identified in the Appendix, if any, attached hereto comprise all the Developments that I have made or conceived prior to my employment by the Company and that are owned or controlled by me, which Developments are excluded from this Agreement. I
understand that it is only necessary to list the title of such Developments and the purpose thereof but not details of the Development itself. If no Developments are identified in the Appendix, it will be deemed that there are no such exclusions.

 7. Further Assurances. 
 I shall,
during my employment and at any time thereafter, at the request and cost of the Company, promptly sign, execute, make and do all such deeds, documents, acts and things as the Company and its duly authorized officers may reasonably require: 

(a) to apply for, obtain, register and vest in the name of the Company alone (unless the Company otherwise directs) patents,
copyrights, trademarks or other analogous protection in any country throughout the world relating to a Development and when so obtained or vested to renew and restore the same; and 

(b) to defend any judicial, opposition or other proceedings in respect of such applications and any judicial, opposition or
other proceeding, petition or application for revocation of any such patent, copyright, trademark or other analogous protection. 
 If the
Company is unable, after reasonable effort, to secure my signature on any application for patent, copyright, trademark or other analogous protection or other documents regarding any legal protection relating to a Development, whether because of my
physical or mental incapacity or for any other reason whatsoever, I hereby irrevocably designate and appoint the Company and its duly authorized officers and agents as my agent and
attorney-in-fact, to act for and in my behalf and stead to execute and file any such application or applications or other documents and to do all other lawfully
permitted acts to further the prosecution and issuance of patent, copyright or trademark registrations or any other legal protection thereon with the same legal force and effect as if executed by me. 

  
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 8. Employment At Will. 

I understand that this Agreement does not constitute an implied or written employment contract and that my employment with the Company is on an
“at-will” basis. Accordingly, I understand that either the Company or I may terminate my employment at any time, for any or no reason. 

9. Severability. 
 I hereby agree that
each provision and the subparts of each provision herein shall be treated as separate and independent clauses, and the unenforceability of any one clause shall in no way impair the enforceability of any of the other clauses of this Agreement.
Moreover, if one or more of the provisions contained in this Agreement shall for any reason be held to be excessively broad as to scope, activity, subject or otherwise so as to be unenforceable at law, such provision or provisions shall be construed
by the appropriate judicial body by limiting or reducing it or them, so as to be enforceable to the maximum extent compatible with the applicable law as it shall then appear. I hereby further agree that the language of all parts of this Agreement
shall in all cases be construed as a whole according to its fair meaning and not strictly for or against either of the parties. 
 10. Amendments;
Waiver. 
 Any amendment to or modification of this Agreement, or any waiver of any provision hereof, shall be in writing and signed by
the Company. Any waiver by the Company of a breach of any provision of this Agreement shall not operate or be construed as a waiver of any subsequent breach of such provision or any other provision hereof. 

11. Survival. 
 This agreement shall be
effective as of the Effective Date. My obligations under this Agreement shall survive the termination of my employment regardless of the manner of such termination and shall be binding upon my heirs, executors, administrators and legal
representatives. 
 12. Assignment. 

The Company shall have the right to assign this Agreement to its successors and assigns, and all covenants and agreements hereunder shall inure
to the benefit of and be enforceable by said successors or assigns. I may not assign this Agreement. 
 13. Representations. 

(a) I represent that my employment with the Company and my performance of all of the terms of this Agreement do not and will not breach any
agreement to keep in confidence proprietary information acquired by me in confidence or in trust prior to my employment by the Company. I have not entered into, and I shall not enter into, any agreement either written or oral in conflict herewith. I
agree that in the course of my employment with the Company, if the Company requests that I undertake activities that will cause me to use Confidential Information of my prior employer, I will inform the Company of that fact. 

  
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 (b) I agree that the restrictions set forth in Paragraph 2 hereof are reasonable and necessary to
protect specific business interests of the Company. I agree that any breach of this Agreement by me will cause irreparable damage to the Company and that in the event of such breach the Company shall have, in addition to any and all remedies of law,
the right to an injunction, specific performance or other equitable relief to prevent the violation of my obligations hereunder. The Company may apply for such injunctive relief in any court of competent jurisdiction without the necessity of posting
any bond or other security. 
 14. Governing Law; Forum Selection Clause. 

This Agreement and any claims arising out of this Agreement (or any other claims arising out of the relationship between the parties) shall be
governed by and construed in accordance with the laws of the State of New York and shall in all respects be interpreted, enforced and governed under the internal and domestic laws of such state, without giving effect to the principles of conflicts
of laws of such state. Any claims or legal actions by one party against the other shall be commenced and maintained in any state or federal court located in such state, and I hereby submit to the jurisdiction and venue of any such court. 

15. Entire Agreement. 
 This Agreement
sets forth the complete, sole and entire agreement between the parties on the subject matter herein and supersedes any and all other agreements, negotiations, discussions, proposals, or understandings, whether oral or written, previously entered
into, discussed or considered by the parties 
 [Signature to appear on the following page.] 

  
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 IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the Effective Date. 

 

	
	 /s/ Paul D. Estrem

	Paul Estrem
	
	Address: 325 Clarewood Circle
	                Greyslake, IL 60030
	
	Date: November 11, 2013

  
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 Exhibit 10.5 
  

 
 November 18, 2013 

Ms. Sue Cammarata 
 630 North State St. Unit 1106 

Chicago, IL 60654 
 Dear Sue, 

We are very pleased to offer you employment at Melinta Therapeutics, Inc. (“Melinta”). Your start date will be effective as of
November 18, 2013. We are very enthusiastic about your joining the Melinta team, and are confident of a mutually beneficial relationship. 

Position and Compensation 
 Your initial position will be
Chief Medical Officer of Melinta, reporting directly to Eugene Sun, Executive Vice President, Research and Development of Melinta. During the course of your employment with Melinta, your position and duties are, of course, subject to change;
provided, however, that Melinta’s ability to change your position and duties will not limit your “good reason” rights under the enclosed Severance Agreement. As a Melinta employee, we expect that you will perform any and
all duties and responsibilities normally associated with your position in a satisfactory manner and to the best of your abilities at all times. In addition, you agree to observe and comply with all the rules, regulations, policies and procedures
established by Melinta from time to time. Your performance will be reviewed formally at the end of the calendar year, and on a periodic basis thereafter as long as you remain employed by Melinta. 

Your initial base pay shall be $16,250, payable semi-monthly (annualized to $390,000). During each fiscal year of your employment with Melinta, you will be
eligible for an annual bonus of no more than 30% of your base salary contingent upon the successful achievement of corporate and individual performance goals. Any bonus to be paid will be determined by the Compensation Committee of the Board of
Directors of Melinta (the “Committee”) or its designee; provided, however, that any annual bonus payable in respect of Melinta’s fiscal year ending December 31, 2013 shall be
pro-rated to reflect the portion of time you are employed hereunder during 2013. Any annual bonus earned in respect of any year will be paid no later than 90 days following the end of such year. You must be
employed by Melinta on the date any bonus is paid in order to receive it, except as otherwise provided in the enclosed Severance Agreement. Melinta will review your compensation periodically. Your compensation also is subject to change, as Melinta
considers necessary or appropriate. 

 Signing Bonus 

In addition, subject to your remaining employed with Melinta through May 18, 2014, you will receive a cash signing bonus in the amount of $100,000,
payable on or about the first regularly scheduled payroll period following May 18, 2014; provided, however, if your employment is terminated by Melinta without Cause, by you with Good Reason or in connection with a Change in
Control, each as defined in the enclosed Severance Agreement, prior to May 18, 2014, you will be entitled to immediate payment of your signing bonus subject to your execution and delivery of the release of claims contemplated in the Severance
Agreement. 
 Benefits 
 Equity: Subject to
approval by the Board of Directors (the “Board”) and/or the Committee, you will be eligible to receive an initial equity grant of options to purchase 563,172 shares of Melinta common stock (the “Initial Grant”), at
an exercise price equal to the fair market value of the common stock on the grant date. Subject to your continued employment with Melinta through each applicable vesting date, twenty-five percent (25%) of the stock options granted will vest on the
first anniversary of the commencement of your employment and the remainder will vest in substantially equal monthly installments during the three (3) year period commencing on the first anniversary of the commencement of your employment. The
Initial Grant shall be subject to the terms and conditions of Melinta’s stock option plan then in effect and standard form of stock option agreement. Additional stock options or other equity grants may also be offered from time to time in the
sole discretion of the Board and/or Committee depending upon certain events, including for example the successful completion of corporate goals. 

Severance: Melinta shall provide severance to you upon termination of your employment in certain circumstances pursuant to the terms set forth in the
enclosed Severance Agreement. 
 Other Benefits: Melinta currently offers various benefits, including group medical and dental insurance, paid time
off (vacation and sick time), a 401(k) plan, short-term disability, long-term disability, and other benefits. These benefits may be modified or changed from time to time at the discretion of Melinta. The present benefit structure and other important
information about the benefits for which you may be eligible is described in other documents, which you will receive upon the commencement of your employment. Where a particular benefit is subject to a formal plan (i.e., medical insurance or
life insurance), eligibility to participate in and receive any particular benefit is governed solely by the applicable plan document. Should you have any questions regarding benefits, please see Human Resources for a copy of the applicable plan
document. 
 Expenses: Melinta will reimburse you for all reasonable and necessary expenses you incur in connection with your employment with
Melinta, subject to your presentment of appropriate documentation, in accordance with the published travel, meals and entertainment expense policies of Melinta. In addition, Melinta will reimburse you for the reasonable cost incurred in moving your
personal belongings to Chicago, Illinois, up to a maximum of $10,000, subject to your presentment of appropriate documentation. 

  
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 Nature of Relationship 

As a Melinta employee, you will be expected to devote all of your working time to the performance of your duties at Melinta throughout your employment with
Melinta. Notwithstanding the foregoing, as long as it does not interfere, individually or in the aggregate, with the performance of your duties for Melinta or create a potential business or fiduciary conflict, you may serve as an officer, director
or trustee of, or otherwise participate in the activities of, educational, welfare, social, religious and civic organizations. While this letter reflects our commitment to employ you and we look forward to a mutually rewarding relationship, this
letter does not constitute a contract (express or implied) for a specific length of employment, and either party may choose to terminate the employment relationship upon written notice to the other at any time and for any reason. You agree to give
the Executive Vice President, Research and Development at least four weeks’ advance written notice if you decide to terminate your employment; provided, that Melinta may, in its sole and absolute discretion, by written notice
accelerate such date of termination and without changing the characterization of such termination provided that Melinta continues to pay you your base salary for the remainder of the four-week notice period. 

Taxes 
 Melinta may withhold from any payments made to you
all applicable taxes, including but not limited to income, employment, and social insurance taxes, as shall be required by law. 
 Noncompetition,
Nondisclosure and Developments Agreement 
 As a condition of your employment and continued employment with Melinta, you are required to sign and comply
with the terms and conditions of the enclosed Noncompetition, Nondisclosure and Developments Agreement. Also, just as Melinta regards the protection of its trade secrets, and other confidential information as a matter of great importance, we also
respect that you may have an obligation to your present and/or prior employers to safeguard the confidential information of those companies, and we expect you to honor them as well. To that end, you should not take any documents or other
confidential information from your employer if and when you depart. Further, we want to make it perfectly clear you should not bring with you to Melinta, or use in the performance of your responsibilities for Melinta any proprietary business or
technical information, materials or documents of a former employer. Finally, you must provide Melinta with a copy of any agreements with a former employer or other party that could restrict your professional activities in any way on behalf of
Melinta. By signing this letter, you represent and warrant to Melinta that you are under no contractual commitments inconsistent with your obligations to Melinta hereunder and that your acceptance of this offer of employment and your performance of
the contemplated services hereunder does not and will not conflict with or result in any breach or default under any agreement, contract or arrangement to which you are a party to or violate any other legal restriction. 

  
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 Background Check; Authorization to Work 

This offer is contingent on the acceptable results of a background check. As required by law, your employment with Melinta is also contingent upon your
providing legal proof of your identity and authorization to work in the United States within three (3) business days of your joining Melinta. 
 This
letter, the enclosed Severance Agreement and the enclosed Employee Noncompetition, Nondisclosure and Developments Agreement constitute our entire offer regarding the terms and conditions of your employment by Melinta. These supersede any prior
agreements, or other promises or statements (whether oral or written) regarding the offered terms of employment. 
 The terms of your employment shall be
governed by and construed under the laws of the State of New York, without giving effect to conflict of laws principles. 

  
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 You may accept this offer of employment and the terms and conditions hereof by signing the enclosed additional
copy of this letter. Your signature on the copy of this letter and your submission of the signed copy to me will evidence your agreement with the terms and conditions set forth in this letter. Please return a copy of the offer letter to me in the
addressed/stamped envelope provided. 
 Sincerely, 
  

	
	 /s/ Eugene
Sun                        
 Eugene
Sun
 Executive Vice President, Research and Development
  

	Accepted and Agreed To:
	  
 /s/ Sue Cammarata

	Sue Cammarata
	  
 11/18/13

	Date

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