Document:

Exhibit 10.25

AMENDMENT
NO. 1 TO

WARRANT

THIS AMENDMENT NO. 1 TO WARRANT (this “Agreement”), by and
between 3Com Corporation, a Delaware Corporation (the “Company”), and
Broadcom Corporation, a California corporation (“Holder”) is made and
entered into as of this 1st day of November, 2002, with respect to the
following facts:

RECITALS

A.            Whereas, the Company
issued to Holder a warrant to acquire up to 7,100,000 shares of the Company’s
common stock at an exercise price of $9.31 per share (the “Warrant”),
which Warrant has an expiration time of 5:00 p.m. Pacific Standard Time on
December 4, 2002; and

B.            Whereas, in
connection with that certain Settlement Agreement made and entered into
effective November 1, 2002 by and between Company and Holder, the Company
and the Holder have agreed to extend the term of the Warrant to 5:00 p.m.
Pacific Standard Time on December 4, 2003.

AGREEMENT

NOW, THEREFORE, for good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, the parties hereto hereby agree
as follows:

1.             Section 1(a) of the
Warrant shall hereby be amended in its entirety to read as follows:

“Subject to the terms and
conditions set forth herein and compliance with any applicable regulatory
requirements, this Warrant shall be exercisable, in whole or in part,
commencing on January 1, 2001 and ending at 5:00 p.m., Pacific
Standard Time, on December 4, 2003 (the “Expiration Date”), and,
except as otherwise provided herein, shall be void thereafter.”

2.             All
other references to the “Expiration Date” and December 4, 2002 in the
Warrant shall hereafter be deemed to refer to December 4, 2003.

3.             This
Agreement shall be governed by, construed, and enforced in accordance with the
laws of the State of Delaware without reference to its principles of conflicts
of law.

[Remainder of page
intentionally left blank]

 

IN WITNESS WHEREOF, the undersigned parties have
executed this Agreement as of the date first above written.

 

	
  3COM CORPORATION

  	
   

  	
  BROADCOM CORPORATION

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  By:

  	
   

  	
   

  	
  By:

  	
   

  
	
  Name:

  	
   

  	
   

  	
  Name:

  	
   

  
	
  Title:

  	
   

  	
   

  	
  Title:

  	
   

  
							

 

 

 

 

-2-EXHIBIT 10.1

                        TERMINATION OF ADVISORY AGREEMENT
                                     BETWEEN
                            AMERIVEST PROPERTIES INC.
                                       AND
                         SHERIDAN REATLY ADVISORS, LLC.

     THIS TERMINATION AGREEMENT is dated as of December 27, 2002 between
AmeriVest Properties Inc., a Maryland corporation (the "Company") and Sheridan
Realty Advisors, LLC, a Colorado limited liability company (the "Advisor").

                                   WITNESSETH:

     WHEREAS, the Company and the Advisor are parties to an Advisory Agreement
originally dated as of December 22, 1999, revised and restated as of March 12,
2001 and further revised and restated as of December 31, 2001 (the "Advisory
Agreement"); and

     WHEREAS, the Board of Directors of the Company and the Advisor have agreed
that, effective as of November 1, 2002, the Advisory Agreement will be
terminated pursuant to the terms and conditions of this Agreement and the
Advisor shall be entitled to receive compensation as provided in the Advisory
Agreement through February 28, 2003.

NOW THEREFORE, in consideration of the premises and of the mutual covenants
herein contained, the parties agree as follows:

1.   Effective Date of Termination. As of November 1, 2002 (the "Effective
Date"), the Advisory Agreement shall be deemed terminated and have no further
force and effect except as specified in this Agreement. As a result of such
termination, the company shall be responsible for all expenses of the Advisor
from and after November 1, 2002 through December 31, 2002, including wages and
salaries, insurance, legal, accounting and consulting fees, payroll expenses,
travel and mileage, investor relations and all other administrative and
day-to-day expenses.

2.   Compensation of Advisor. The Advisor shall be entitled to all compensation
earned through December 31, 2002 for transactions completed or under contract,
which includes the following amounts:

     2.1  Advisory Fees. Advisory fees in accordance with Section 6.1 of the
          Advisory Agreement in the amount of $765,470 payable in connection
          with the acquisition of The Centerra Building in Denver, the Chateau
          Plaza building in Dallas and the acquisition and development of the
          Keystone Building IV in Indianapolis; plus

     2.2  Capital Project Fees. Capital project fees in accordance with Section
          6.2 of the Advisory Agreement in the amount of $100,000 payable in
          connection with capital projects commenced at The Centerra Building,
          the Kellogg Building and Keystone Building IV during 2002; plus

<PAGE>

     2.3  Contingent Advisory Fee. An estimated additional advisory fee in
          accordance with Section 6.1 of the Advisory Agreement in the amount of
          $250,000 in connection with the acquisition of a building in Phoenix,
          Arizona which is under contract by the Company and is subject to
          certain conditions. In the event the Phoenix acquisition does not
          close for any reason, the accrued fees will not be paid.

3.   Agreement to Exercise Warrants. The Advisor agrees that it will use the
compensation payable hereunder which has not been previously paid to exercise
incentive warrants previously received by the Advisor under the Advisory
Agreement. Under the terms of the Advisory Agreement, the incentive warrants are
not exercisable until January 1, 2003.

4.   Cooperation of Advisor. Upon execution of this Agreement and the
compensation set forth herein, the Advisor shall immediately:

     4.1  pay over to the Company all monies collected and held for the account
          of the Company pursuant to the Advisory Agreement;
     4.2  deliver to the Directors a full accounting, including a statement
          showing all payments collected by it and a statement of any monies
          held by it, covering the period following the date of the last
          accounting furnished to the Directors;
     4.3  deliver to the Directors all property and documents of the Company
          then in the custody of the Advisor; and
     4.4  cooperate with the Company and take all reasonable additional steps
          requested to assist the Company in making an orderly transition of the
          advisory functions.

5.   Full Payment. The parties agree that this Agreement constitutes full
satisfaction of all fees, expenses and other obligations provided for in the
Advisory Agreement.

6.   Confidentiality. The Advisor acknowledges that it and its employees have
had access to certain information concerning the Company and its business that
was provided solely in connection with Advisor's duties under the Advisory
Agreement. Any other use of this information at any time during or after the
term of the Advisory Agreement is prohibited.

7.   Complete Agreement. The parties acknowledge and agree that this Termination
Agreement and the terms of the incentive warrants constitute the complete
agreements between them and that no oral modification of this Termination
Agreement is permissible. The parties further acknowledge and agree that this
Termination Agreement and the terms contained herein supersede all previous
contracts and agreements between the parties, including but not limited to the
Advisory Agreement, as amended and that all previous contracts and agreements
between the parties (other than the incentive warrant agreement), shall become
null and void upon execution of this Termination Agreement.

<PAGE>

8.   Binding Agreement. This Termination Agreement shall be binding upon any and
all successors and assigns of Advisor and the Company.

9.   Colorado Law. Except for issues or matters as to which federal law is
applicable, this Termination Agreement shall be governed by and construed and
enforced in accordance with the laws of the State of Colorado without giving
effect to the conflicts of law principles thereof.

AMERIVEST PROPERTIES INC.                  SHERIDAN REALTY ADVISORS, LLC

By: /s/ William T. Atkins                      By: /s/ Charles K. Knight
-------------------------                      -------------------------
William T. Atkins                              Charles K. Knight
Chairman and Chief Executive Officer           President and Co-Managing MemberEXHIBIT 10.1

                                                CONFIDENTIAL TREATMENT REQUESTED
                                         WITH RESPECT TO CERTAIN PORTIONS HEREOF
                                                              DENOTED WITH "***"

                              SUB-LICENSE AGREEMENT
                                     BETWEEN
                    BIODELIVERY SCIENCES INTERNATIONAL, INC.
                                       AND
                    PHARMACEUTICAL PRODUCTS DEVELOPMENT, INC.
                                   DATED AS OF
                                December 31, 2002

This Sub-License Agreement (this "Agreement") effective as of December 31, 2002,
by and between BIODELIVERY SCIENCES INTERNATIONAL, INC., a Delaware corporation,
having its principal place of business at 185 South Orange Avenue,
Administrative Building No. 4, Newark, NJ 07103 ("BDSI") and PHARMACEUTICAL
PRODUCT DEVELOPMENT, INC., a North Carolina corporation, having its principal
place of business at 3151 South Seventeenth Street, Wilmington, NC 28412
("PPDI") (collectively the "Parties").

                                   WITNESSETH:

Whereas, BDSI has rights to certain Licensed Technology (hereinafter defined)
relating to cochleates, cochleate derivatives, and proteoliposomes, and
nano-encapsulation;

Whereas, PPDI recognizes that the Licensed Technology represents a valuable
means of delivering Component Products for the use and/or sale in the treatment
or prevention of human and/or animal diseases;

Whereas, PPDI wishes to enter into an agreement to obtain exclusive licenses for
specific Component Products which utilize Licensed Technology in the Field
(hereinafter defined) from BDSI in order to research, develop and commercialize
therapeutic products made in accordance therewith; and

WHEREAS, BDSI is willing to grant such licenses to PPDI under the terms and
conditions set forth in this Agreement.

NOW, THEREFORE, in consideration of the various promises and undertakings set
forth herein, the Parties agree as follows:

                             ARTICLE 1 - DEFINITIONS

As used herein, capitalized terms shall have the following meanings:

1.1 "Affiliate", with respect to any Party, shall mean any person or entity
controlling, controlled by, or under common control with such Party. For these
purposes, "control" shall refer to (i) the possession, directly or indirectly,
of the power to direct the management or policies of a person or entity, whether
through the ownership of voting securities, by contract or otherwise or (ii) the
ownership, directly or indirectly, of at least 50% of the voting securities or
other ownership interest of a person or entity.

<PAGE>

1.2 "BDSI Personnel" means any BDSI employee, intern or consultant who
participates in any Sponsored Research Program or any PPDI Evaluation Program in
any manner or who acquires knowledge of any test data, clinical information or
any other information resulting from any Sponsored Research Program or any PPDI
Evaluation Program which is deemed a trade secret or confidential or proprietary
to PPDI or BDSI, such as an independent contractor (including any consultant
under an obligation of confidentiality), or any research collaborator.

1.3 "Commercial Sale" shall mean any sale which transfers physical possession
and title to any Licensed Product (hereinafter defined) to a Third Party in
exchange for value and after which transfer the seller has no right or power to
determine the Third Party's resale price. Transfer for research, development or
testing purposes shall not constitute a Commercial Sale.

1.4 "Component Product" shall mean any *** Product, *** Product or *** Product.
CONFIDENTIAL TREATMENT REQUESTED

1.5 "*** Products" shall mean ***. CONFIDENTIAL TREATMENT REQUESTED

1.6 "Effective Date of this Agreement" shall mean the date first written above.

1.7 "Evaluation Agreement" shall mean the letter agreement between BDSI and
PPDI, dated November 4, 2002, attached hereto as Exhibit A.

1.8 "Field" shall mean delivery of Component Products to all living systems for
health care applications.

1.9 "First Commercial Sale" means the first Commercial Sale.

1.10 "Joint Invention" shall mean any Invention for which it is determined, in
accordance with applicable law, that both: (i) employees or agents of PPDI or
any other persons obligated to assign such Invention to PPDI, and (ii) BDSI
Personnel or any other persons obliged to assign such Invention to BDSI, are
joint inventors of such Invention.

1.11 "Licensed Patents" shall mean any current and future Patent, owned or
controlled by BDSI, or any of the same jointly owned or controlled by BDSI and
that relate to the Licensed Technology, including Patents set forth on Exhibit
B.

1.12 "Licensed Product" shall mean any Component Product that is in suitable
form for Commercial Sale.

1.13 "Licensed Technology" shall mean any and all information, and all
patentable and non-patentable inventions (including, without limitation, all
Inventions and Joint Inventions), improvements, discoveries, claims, formulae,
processes, methods, trade secrets, technologies, data and know-how owned,
licensed or controlled by BDSI or to which BDSI has the right to grant licenses
or sublicenses before or during the term of this Agreement: (i) related to the
cochleate, cochleate derivatives, proteoliposome, and nano-encochleation
technology described in Exhibit C, (ii) claimed, covered or disclosed in any
patent or patent application listed in Exhibit B which relates to the cochleate,
cochleate derivative, proteoliposome nano-encochleation technology described in
Exhibit C, or (iii) derived from any Sponsored Research Program (hereinafter
defined) or any PPDI Evaluation Program (hereinafter defined).

                                       2
<PAGE>

1.14 "Net Sales" shall mean the gross amount invoiced for all Licensed Products
sold by PPDI and/or its Affiliates in arm's length sales or commercial
transactions to a Third Party (excluding sales to Sublicensees for their
resale), less deductions for:

          (a) commissions, trade, quantity and cash discounts or rebates
     actually allowed or given;

          (b) credits, allowances or refunds given or made for rejected,
     outdated or returned Components, if applicable;

          (c) any tax or government charge (other than an income tax) levied on
     the sale, transportation or delivery of a Licensed Product and borne by the
     seller thereof;

          (d) any prepaid or invoiced charges for freight, postage, shipping,
     import or export taxes, insurance or charges for returnable containers; and

          (e) in those cases when the cost to PPDI of manufacturing or supplying
     a Component is at least as great as the fair market value thereof, PPDI's
     fully-allocated cost for the manufacture or supply of the Component.

1.15 "*** Product" shall ***. CONFIDENTIAL TREATMENT REQUESTED

1.16 "Party" shall mean PPDI or BDSI and, when used in the plural, shall mean
PPDI and BDSI.

1.17 "Patent" means (i) unexpired letters patent (including inventor's
certificates) which have not been held invalid or unenforceable by a court of
competent jurisdiction from which no appeal can be taken or has been taken
within the required time period, including without limitation any substitution,
extension, registration, confirmation, reissue, re-examination, renewal or any
like filing thereof and (ii) pending applications for letters patent, including
without limitation any continuation, division or continuation-in-part thereof
and any provisional applications.

1.18 "*** Product" shall mean ***. CONFIDENTIAL TREATMENT REQUESTED

1.19 "PPDI Evaluation Program" shall mean any research and development conducted
by or on behalf of PPDI pursuant to the Evaluation Agreement.

1.20 "Publication" means any written or oral publication or disclosure resulting
from or involving the Licensed Technology or the subject matter of any Sponsored
Research Program or PPDI Evaluation Program, and includes but is not limited to
a publication or disclosure in books, journals, theses, the media, trade
publications, scientific meetings, poster sessions, and symposia.

1.21 "Sponsored Research Program" shall mean any research conducted by BDSI, in
collaboration with PPDI.

                                       3
<PAGE>

1.22 "Sublicensee" shall mean any Third Party granted a sublicense by PPDI
pursuant to Section 3.3 hereof.

1.23 "Territory" shall mean the entire world.

1.24 "Third Party" means any person or entity other than PPDI, BDSI or any
Affiliate of either PPDI or BDSI.

1.25 "Valid Claim" shall mean a claim of any issued or granted Licensed Patent
which has not been held invalid or unenforceable by final decision of a court or
other governmental agency of competent jurisdiction, unappealable or unappealed
within the time allowed for appeal, and which is not admitted to be invalid or
unenforceable through reissue, disclaimer or otherwise.

                   ARTICLE 2 - REPRESENTATIONS AND WARRANTIES

2.1 Representations and Warranties of Both Parties. Each Party represents and
warrants to the other Party that: (i) it is free to enter into this Agreement;
(ii) in so doing, it will not violate any other agreement to which it is a
party; and (iii) it has taken all corporate action necessary to authorize the
execution and delivery of this Agreement and the performance of its obligations
under this Agreement.

2.2 Representations and Warranties of BDSI. BDSI hereby represents and warrants
that:

          (a) BDSI either owns or licenses all of the Licensed Patents listed on
     Exhibit B, and has the exclusive right to grant licenses and sublicenses
     therefore without the consent or approval of any Third Party, except as
     provided in Section 2.3;

          (b) BDSI own or licenses all of the Licensed Technology in existence
     on the date of this Agreement, and has the right to grant licenses and
     sublicenses therefore without the consent or approval of any Third Party;

          (c) To the best of BDSI's knowledge, all the Licensed Patents listed
     on Exhibit B are in full force and effect and have been maintained to date;

          (d) BDSI is not aware of any asserted or unasserted claim or demand
     against the Licensed Technology;

          (e) To the best of BDSI's knowledge, none of the Licensed Technology
     infringes upon any patent or other proprietary rights of any other Third
     Party; and

          (f) BDSI has not entered into any agreement with any Third Party which
     is in conflict with the rights granted to PPDI pursuant to this Agreement.

2.3 Disclaimer of Other Warranties. EXCEPT AS PROVIDED HEREIN, THE LICENSED
TECHNOLOGY IS PROVIDED WITHOUT WARRANTY OF MERCHANTABILITY OR FITNESS FOR A
PARTICULAR PURPOSE OR ANY OTHER WARRANTY, EXPRESS OR IMPLIED. EXCEPT AS
EXPRESSLY PROVIDED, NEITHER PARTY MAKES ANY REPRESENTATION OR WARRANTY THAT THE

                                       4
<PAGE>

LICENSED TECHNOLOGY WILL NOT INFRINGE ANY PATENT OR OTHER PROPRIETARY RIGHT OF A
THIRD PARTY.

2.4 Employee Agreements. Each Party warrants that it has, and covenants that it
    -------------------
will have, entered into a proprietary information and inventions agreement with
each of its employees prior to the time that any such employee shall receive
confidential information from a disclosing party or begin work related to this
Agreement. Such agreement shall minimally set forth employee obligations to
assign inventions to the inventing Party and to maintain confidentiality of
confidential information consistent with the terms of this Agreement.

                            ARTICLE 3 - LICENSE GRANT

3.1 Grant of License. Subject to the terms and conditions of this Agreement,
    ----------------
BDSI hereby grants to PPDI an exclusive license throughout the Territory, with
the right to grant sublicenses (subject to Sections 3.4 and 3.5), to make, use
or sell Licensed Technology and Licensed Patents in the Field for research,
development and commercialization of one *** Product and one *** Product or ***
Product. CONFIDENTIAL TREATMENT REQUESTED

3.2 Reservation of Rights. The license granted in Section 3.1 of this Agreement
    ---------------------
is subject to a reserved right in BDSI to make, use and sell Licensed Technology
and Licensed Patents for any *** Product, *** Product or *** Product for which
BDSI has not given consent to PPDI for development of a Licensed Product
pursuant to Section 3.3 or that is not the subject of an Evaluation Agreement or
a Sponsored Research Agreement. After BDSI has consented to the development of
any *** Product, *** Product or *** Product, or a *** Product, *** Product or
*** Product becomes the subject of an Evaluation Agreement or a Sponsored
Research Agreement, BDSI shall not thereafter, directly or indirectly, make, use
or sell the Licensed Technology or Licensed Patents for research, development or
commercialization of any such *** Product, *** Product or *** Product.
CONFIDENTIAL TREATMENT REQUESTED

3.3 *** Product Approval. Prior to developing a *** Product, *** Product or ***
        ----------------
Product, PPDI will notify BDSI in writing regarding the identity of such Product
and PPDI's intent to develop the same ("Product Development Notification"). BDSI
shall notify PPDI in writing of its consent to PPDI's request to develop a ***
Product, *** Product or *** Product within thirty (30) days of receipt of a
Product Development Notification. In the event that BDSI fails to provide a
written response to PPDI within the 30-day period, then BDSI shall be deemed to
have consented to PPDI's request to develop a *** Product, *** Product or ***
Product. BDSI agrees that consent shall not be withheld unless BDSI clearly
demonstrates that PPDI's proposed *** Product, *** Product or *** Product will
conflict with a product being developed by BDSI. In the event that BDSI refuses
consent, BDSI shall provide to PPDI a written statement describing BDSI's
product and the basis for withholding consent. BDSI shall provide PPDI with
written notification of any *** Product, *** Product or *** Product under
development by BDSI using Licensed Technology. PPDI shall not be obligated to
obtain consent for any *** Product, *** Product or *** Product that is the
subject of an Evaluation Agreement or a Sponsored Research Agreement.
CONFIDENTIAL TREATMENT REQUESTED

3.4 Right to Grant Sublicenses. PPDI shall have the right to sublicense the
    --------------------------
License Technology. Each sublicense granted by PPDI pursuant to this Agreement,
shall be consistent the provisions of this Agreement. Prior to the grant of each
sublicense hereunder, PPDI shall provide BDSI a redacted copy of the sublicense.

                                       5
<PAGE>

3.5 PPDI Responsibility for Sublicense. PPDI shall be responsible for and
    ----------------------------------
guarantees the performance of its Sublicensees, including the payment of all
royalties to BDSI as provided in Article 4 as though PPDI itself had sold the
Licensed Product and the provision of sales and other reports hereunder. Upon
termination of this Agreement, all sublicenses shall revert directly to BDSI,
which may at its election recognize or disaffirm each such sublicense on a
case-by-case basis.

3.6 Inventions.
    ----------

          (a) Pre-Existing Rights. Except as expressly provided herein or in an
              -------------------
     Exhibit, nothing in this Agreement shall be construed as a grant to either
     party of any ownership or other interest in any copyrights, patents,
     trademarks, know-how, inventions, trade secrets and registrations and
     applications for the registration thereof ("Intellectual Property") of the
     other created on or before the Effective Date.

          (b) *** Products. Except as expressly provided in subsection (c)
                  --------
     below, any and all Intellectual Property developed by the Parties, either
     solely or jointly, during the development of a Licensed Product by PPDI
     shall be the sole and exclusive property of PPDI. BDSI agrees to reasonably
     cooperate with PPDI to execute, or cause BDSI Personnel to execute, any
     documents necessary or desirable to secure or perfect PPDI's legal rights
     and worldwide ownership in such Intellectual Property, including, but not
     limited to documents relating to patent, trademark and copyright
     applications, at PPDI's expense. BDSI shall not at any time, in any manner,
     during or after this Agreement, under any circumstances, be entitled to or
     claim any right, title or interest herein or any commission, fee or other
     direct or indirect benefit from PPDI or Affiliate, in respect of such
     Intellectual Property created by BDSI hereunder. CONFIDENTIAL TREATMENT
     REQUESTED

          (c) Exclusion. Intellectual Property shall not include any
              ---------
     improvements to Licensed Patents that exist independently of the ***
     Product or Licensed Product ("BDSI Intellectual Property"). Whether BDSI
     Intellectual Property results from PPDI's efforts or the joint efforts of
     the Parties, all BDSI Intellectual Property shall be the exclusive property
     of BDSI, subject, however, to the royalty-free license granted to PPDI in
     Section 3.7 below. CONFIDENTIAL TREATMENT REQUESTED

3.7 License to BDSI Intellectual Property. BDSI hereby grants to PPDI a
    -------------------------------------
fully-paid, worldwide, non-exclusive license to BDSI Intellectual Property. BDSI
shall immediately notify PPDI in writing of the development of any BDSI
Intellectual Property and this Agreement shall be amended effective as of the
date of such notice to add such BDSI Intellectual Property to Licensed
Technology and/or Licensed Patents without any further action on the part of
either party.

3.8 ***. CONFIDENTIAL TREATMENT REQUESTED.

                    ARTICLE 4 - ROYALTY PAYMENTS AND REPORTS

4.1 License Fee. In consideration of the license grant set forth in this
    -----------
Agreement, PPDI shall pay to BDSI *** within thirty (30) days of the Effective
Date.

4.2 ***. CONFIDENTIAL TREATMENT REQUESTED

4.3 Milestone Payments. In addition to the other payments required to be made by
    ------------------
PPDI, its Sublicensee and Affiliates hereunder, PPDI shall pay to BDSI the
following one-time milestone payments (each a "Milestone Payment" and

                                       6
<PAGE>

collectively the "Milestone Payments") with respect to each Licensed Product as
follows:

*** [text omitted relating to Milestone Payments]. CONFIDENTIAL TREATMENT
REQUESTED.

4.4 Running Royalty. In consideration of the license rights set forth in Article
    ---------------
3 hereof, PPDI shall, during the periods specified in Section 4.6, pay earned
royalties on the Commercial Sale of Licensed Products based on Net Sales of all
Licensed Products by PPDI and its Affiliates and Sublicensee(s) at the rate of
*** ("Running Royalty"). CONFIDENTIAL TREATMENT REQUESTED

BDSI agrees to discuss with PPDI and give due consideration to PPDI's views as
to other appropriate and reasonable reductions of such rate at any time that
PPDI believes that market conditions make it economically unreasonable to pay
BDSI a Running Royalty at the rates above on any Licensed Product. Running
Royalty payments may be offset by credits only as provided in Sections 4.5
hereof.

4.5 Credits. ***. CONFIDENTIAL TREATMENT REQUESTED
    -------

4.6 Term of Running Royalty Obligations. The Milestone Payment and Running
    ------------------------------------
Royalty obligations specified in Sections 4.3 and 4.4 above shall continue as to
each Licensed Product in the Territory for the term of the last to expire of the
Licensed Patent rights covering the Licensed Product.

4.7 Date and Place of Sale. Licensed Products shall be considered sold when
    ----------------------
PPDI, an Affiliate or Sublicensee is paid by a purchaser for a Licensed Product.

4.8 Payments by PPDI. Running Royalties and Milestone Payments accruing to BDSI
    ----------------
pursuant to Sections 4.3, 4.4 and 4.7 shall be paid by PPDI to BDSI no later
than sixty (60) days following the end of the calendar half-year during which
such Running Royalties or Milestone Payments accrued.

4.9 Place of Payment. All Running Royalty payments due BDSI shall be payable in
    ----------------
United States dollars by wire transfer to a bank account designated by BDSI from
time to time. PPDI shall convert all non-U.S. dollar sales to U.S. dollars using
the average exchange rates quoted in the Wall Street Journal for the final day
of each month in the relevant period for which the Running Royalty is being
paid. In the event payment of any Running Royalties is restricted or prohibited
by the laws or regulations of a particular country, then to the extent of such a
restriction and prohibition, Running Royalties shall be paid to BDSI in that
country and in the currency of said country into an account to be designated by
BDSI.

4.10 Third Party Consideration. In the case of a Commercial Sale other than in
     -------------------------
an arm's-length transaction exclusively for money, such as barter or
counter-trade, the amount of such Sale shall be calculated using the fair market
value of such Licensed Product (if higher than the stated sales price) in the
country of disposition.

4.11 Taxation of Payments.
     --------------------

          (a) Insofar as any payment that is due BDSI under this Agreement is
     subject to any tax, duty, levy, or other government imposition, BDSI agrees
     to bear any and all such taxes, duties, levies or impositions. BDSI hereby

                                       7
<PAGE>

     authorizes PPDI to withhold such taxes, duties, levies or impositions from
     the payments which are payable to BDSI in accordance with this Agreement if
     PPDI is required to do so under the laws of the United States or any
     country in the Territory where such taxes, duties, levies or impositions
     are payable. Whenever PPDI deducts such tax, duty, levy or imposition from
     any payments due BDSI, then PPDI shall furnish BDSI with a certificate
     showing the payment of thereof to the United States or any country in the
     Territory.

          (b) In the event the Running Royalty payments which are due to BDSI
     under this Agreement are subject to value added taxation by any government,
     then BDSI shall bear such value added tax in full and PPDI shall be
     reimbursed therefor. If appropriate, BDSI may add such value added taxes to
     its royalty accounts, provided such value added taxes are credited against
     PPDI's value added tax debt and PPDI is reimbursed in full with respect
     thereto. Notwithstanding anything herein to the contrary, PPDI shall have
     no liability for any value added tax directly or indirectly relating to the
     Running Royalties.

          (c) In the event any payment by PPDI to BDSI is subject to a
     withholding or other income tax in any country in the Territory, PPDI shall
     so advise BDSI promptly following PPDI becoming aware of the applicability
     of any such tax. BDSI shall have the right to contest with the appropriate
     governmental body any such proposed withholding and PPDI shall provide, at
     BDSI's expense, reasonable cooperation to BDSI in any such contest. PPDI
     shall provide BDSI with such receipts or other evidence of any tax withheld
     as is necessary for BDSI to claim any credit or deduction available to it
     in other jurisdictions. Payments to BDSI shall only be reduced for
     withholding taxes imposed by the jurisdiction out of which the payment is
     directly made to the BDSI.

4.12 Interest. All payments due hereunder from PPDI that are not paid to BDSI
     --------
when due and payable as specified in this agreement shall bear interest at an
annual rate equal to the prime rate ("Prime Rate") for U.S. dollar deposits in
effect from time to time, as published daily in the Wall Street Journal plus 2%,
compounded monthly from the date due until paid, or at such lower rate of
interest as shall then be the maximum rate permitted by applicable law.

4.13 Right to Documentation. Upon request, BDSI shall have the right to request
     ----------------------
reasonable documentation of PPDI's calculations to determine PPDI's Net Sales
for the Licensed Products and to request discussion of such calculations with
appropriate representatives of PPDI.

4.14 Records Retention. PPDI, its Sublicensee and Affiliates shall keep complete
     -----------------
and accurate records pertaining to the sale of Licensed Products in the
Territory and covering all transactions which Net Sales are derived for a period
of three (3) calendar years after the year in which such sales occurred, and in
sufficient detail to permit BDSI to confirm the accuracy of Running Royalty
calculations hereunder.

4.15 Audit Request. At the request and expense of BDSI, PPDI, its Affiliates and
     -------------
Sublicensees shall permit an independent, certified public accountant appointed
by BDSI acceptable to PPDI or its Affiliates, at reasonable times and upon
reasonable notice, to examine those records and all other material documents
relating to or relevant to Net Sales and Sublicensee income in the possession or
control of PPDI, its Affiliates or Sublicensees, for a period of three (3) years
after such Running Royalties have accrued, as may be necessary to: (i) determine
the correctness of any report or payment made under this Agreement; or (ii)
obtain information as to the Running Royalties payable for any calendar quarter
in the case of PPDI's or its Affiliate's failure to report or pay pursuant to
this Agreement. Said accountant shall not disclose to BDSI any information other
than information relating to said reports, Running Royalties, and payments.
Results of any such examination shall be made available to both Parties. BDSI

                                       8
<PAGE>

shall bear the full cost of the performance of any such audit, unless such audit
demonstrates underpayment of royalties by PPDI of more than ten percent (10%)
from the amount of the original Running Royalty payment made by PPDI. In such
event, PPDI shall bear the full cost of the performance of such audit. BDSI
shall have no right to audit or seek payment of any Running Royalties for any
Commercial Sale after the date which is three years from the date of such
Commercial Sale.

            ARTICLE 6 - PATENT PROSECUTION; ENFORCEMENT; INFRINGEMENT

6.1 Patent Prosecution and Maintenance.
    ----------------------------------

          (a) BDSI shall continue to have full responsibility for and shall
     control the preparation and prosecution of all Patents and the maintenance
     of all Patents related to the Licensed Technology and included in the
     Licensed Patents, provided that all actions related thereto requested by
     PPDI, including, without limitation, the filing and prosecution of foreign
     Patents, shall be taken by BDSI and PPDI shall be a full participant in the
     preparation and review of all filings. BDSI agree to take all actions
     reasonably necessary to diligently prosecute and maintain any Patents in
     the countries which PPDI determines Patents will be filed and prosecuted,
     and where the Patents will be maintained. The Parties acknowledge and agree
     that they intend for BDSI to file and prosecute Patents and maintain
     patents in all major commercial markets where viable Patent protection is
     available.

          (b) BDSI shall use qualified independent patent counsel to file and
     prosecute all patent applications required pursuant to Section 6.1(a). PPDI
     or its representatives shall be entitled to meet and confer with such
     patent counsel at reasonable times and places. BDSI shall promptly provide
     copies to PPDI of any communications from any patent office relating to the
     Licensed Technology or the Licensed Patents, and allow PPDI and its patent
     counsel the opportunity to attend (either in person or by phone) any
     conferences (conducted in person or by phone) to be made with or to any
     patent office regarding the Licensed Technology or the Licensed Patents. In
     addition, filing deadlines permitting, at least thirty (30) days prior to
     the filing of any patent application, amendment thereto, or response to any
     patent office action related to the Licensed Technology or the Licensed
     Patents, BDSI shall provide PPDI with a copy of each such patent
     application, amendment or response and will provide PPDI and its legal
     counsel with an opportunity to consult with BDSI and its patent counsel
     regarding the filing and contents of any such application, amendment or
     response, and the advice and suggestions of PPDI and its legal counsel
     shall be seriously taken into consideration by BDSI and its legal counsel
     in connection with such filing. BDSI shall also provide PPDI with copies of
     any patentability search reports made by patent counsel, including Patents
     located, a copy of each Patent, and each Patent that issues thereon.

          (c) In accordance with Section 3.5(b) hereof, PPDI shall be solely
     responsible for the preparation, filing, prosecution and maintenance of all
     Patents relating to Intellectual Property. BDSI agrees to reasonably
     cooperate with PPDI to document ownership of such Intellectual Property
     rights according to Section 3.5(b) hereof, including without limitation,
     obtaining execution of separate assignment documents for recordation
     purposes in the applicable patent offices. BDSI further agrees to
     reasonably cooperate in the preparation and prosecution of patent
     applications on such Intellectual Property pursuant to Section 3.5(b)
     hereof. In the event that PPDI does not desire to proceed with the
     prosecution of a Patent and indicates such by written notice, BDSI may
     obtain such Patent at no cost to PPDI.

                                       9
<PAGE>

          (d) Except as provided for above in Section 6.1(c), in the event that
     the Parties elect to file one or more Patents comprising Joint Inventions,
     the Parties shall confer on how the preparation and prosecution of such
     applications shall be accomplished. Once the Parties agree on how to
     proceed with respect to the preparation and filing of Patents comprising
     Joint Inventions, all other provisions of this Section 6.1 shall govern
     such preparation, filing, maintenance and prosecution.

          (e) Both Parties agree to cooperate with the other Party to execute
     all lawful papers and instruments, to make all rightful oaths and
     declarations and to provide consultation and assistance as may be necessary
     in the preparation, prosecution, maintenance, and reinforcement of all such
     Patents.

6.2 Limitations on Publications. The Parties agree that no one Party shall
    ---------------------------
publish the results of any studies, whether conducted by its own employees or in
conjunction with a Third Party, carried out pursuant to this Agreement or
confidential information received from the other Party that is relating to a
Component or Licensed Product, without the prior written approval of the other
Party. Each Party agrees to provide the other Party with a copy of any proposed
abstracts, presentations, manuscripts, or any other disclosure which discloses
clinical study results pursuant to this Agreement or confidential information
received from the other Party at least one hundred twenty (120) days prior to
their intended submission for publication and agrees not to submit or present
such disclosure until the Party not seeking to disclose such information
provides its prior written approval. Such written approval will not be
unreasonably withheld unless such proposed disclosure could reasonably harm or
impair a Party's intellectual property assets or may reasonably cause commercial
harm to a Party.

6.3 Notification of Infringement. If either Party learns of an infringement or
    ----------------------------
threatened infringement by a Third Party of any Licensed Patent granted
hereunder within the Territory, such Party shall promptly notify the other Party
and shall provide such other Party with available evidence of such infringement.
Section 6.3 shall then be applicable.

6.4 Patent Enforcement. BDSI shall have the first right, but not the duty, to
    ------------------
institute patent infringement actions against third parties based on any
Licensed Patent under this Agreement. If BDSI does not institute an infringement
proceeding against an offending Third Party within ninety (90) days after
receipt of notice from PPDI, PPDI shall have the right, but not the duty, to
institute such an action. The costs and expenses of any such action (including
fees of attorneys and other professionals) shall be borne by the Party
instituting the action, or, if the Parties elect to cooperate in instituting and
maintaining such action, such costs and expenses shall be borne by the Parties
in such proportions as they may agree in writing. Each Party shall execute all
necessary and proper documents and take such actions as shall be appropriate to
allow the other Party to institute and prosecute such infringement actions. Any
award paid by third parties as a result of such an infringement action (whether
by way of settlement or otherwise) shall be paid to the Party who instituted and
maintained such action, or, if both Parties instituted and maintained such
action, such award shall be allocated among the Parties in proportion to their
respective contributions to the costs and expenses incurred in such action.

6.5 Infringement Action by Third Parties.
    ------------------------------------

          (a) In the event of the institution of any claim or suit by a Third
     Party against PPDI for patent infringement involving the manufacture, use,
     lease or sale of any Licensed Product in the Territory, PPDI shall promptly
     notify BDSI in writing of such claim or suit. PPDI shall have the right to
     defend such claim or suit at its own expense, and BDSI hereby agrees to
     assist and cooperate with PPDI, at BDSI's own expense, to the extent

                                       10
<PAGE>

     necessary in the defense of such claim or suit. During the pendency of such
     claim or suit, PPDI shall continue to make all payments due under this
     Agreement, but shall have a credit against Milestone Payments and Running
     Royalties otherwise payable hereunder for the full amount of all costs and
     expenses incurred by PPDI in defending against such claim or suit;
     provided, however, that in applying the credit against any Milestone
     Payments or Running Royalty payment, the amount of such payment shall not
     be reduced by more than 50% and any remaining credit shall be applied
     against subsequent Milestone Payments or Running Royalty payments .

          (b) If as a result of any judgment, award, decree or settlement
     resulting from a claim or action instituted by a Third Party, PPDI is
     required to pay a royalty or other amounts to such Third Party ("Third
     Party Royalty"), PPDI shall continue to pay Running Royalties for such
     Licensed Products in the country which is the subject of such action, but
     shall be entitled to a credit against such payments in an amount equal to
     the Third Party Royalty, but in no event shall such credit be more than the
     Running Royalties due hereunder for such Licensed Products in such country
     which is the subject of such action and any remaining credit shall be
     applied against subsequent Milestone Payments or Running Royalty payments.
     In addition, if PPDI is required to pay damages to such Third Party, and
     such damages are not otherwise reimbursed by BDSI, PPDI shall be entitled
     to a credit against Running Royalty payments in an amount equal to such
     damages, to the extent paid by PPDI to such Third Party, but in no event
     shall the total credit provided hereunder be more than such Running
     Royalties due hereunder for such Licensed Products in such country which is
     the subject of such action.

                           ARTICLE 7 - CONFIDENTIALITY

7.1 Use of Name. BDSI agree not to use directly or indirectly PPDI's name
    ------------
without PPDI's prior written consent. PPDI agrees not to use directly or
indirectly BDSI's name or information without BDSI's prior written consent.
Notwithstanding the foregoing, PPDI and BDSI may include an accurate description
of the terms of this Agreement to the extent required under federal or state
securities or other disclosure; and PPDI may use BDSI's names in various
documents used by PPDI for capital raising and financing purposes.

7.2 Confidentiality; Exceptions. Except to the extent expressly authorized by
    ---------------------------
this Agreement or otherwise agreed in writing, the Parties agree that, for the
term of this Agreement and for three (3) years thereafter, the receiving Party
shall keep completely confidential and shall not publish or otherwise disclose
and shall not use for any purpose other than proper performance hereunder any
information furnished to it by the other Party pursuant to this Agreement,
except to the extent that it can be established by the receiving Party by
competent proof that such information:

          (a) was already known to the receiving Party, other than under an
     obligation of confidentiality, at the time of disclosure by the other
     Party;

          (b) was generally available to the public or otherwise part of the
     public domain at the time of its disclosure to the receiving Party;

          (c) became generally available to the public or otherwise part of the
     public domain after its disclosure and other than through any act or
     omission of the receiving Party in breach of this Agreement;

                                       11
<PAGE>

          (d) was disclosed to the receiving Party, other than under an
     obligation of confidentiality, by a Third Party who had no obligation to
     the disclosing Party not to disclose such information to others; or

          (e) was independently developed by or for the receiving Party by
     persons not having access to such information, as determined by the written
     records of such party.

Each Party may disclose the other's information to the extent such disclosure is
reasonably necessary in filing or prosecuting Patents, prosecuting or defending
litigation, complying with applicable governmental regulations, undertaking
basic research with outside collaborators, or conducting preclinical or clinical
trials provided that if a Party is required by law to make any such disclosure
of the other Party's secret or confidential information it will, except where
impracticable for necessary disclosures, for example to physicians conducting
studies or to health authorities, give reasonable advance notice to the other
Party of such disclosure requirement and, except to the extent inappropriate in
the case of patent applications, will use its best efforts to secure
confidential treatment of such information required to be disclosed.

                           ARTICLE 8 - INDEMNIFICATION

8.1 Indemnification by PPDI. PPDI shall defend, indemnify and hold BDSI, its
    -----------------------
officers, directors, employees and consultants harmless from and against any and
all Third Party claims, suits or demands, threatened or filed, ("Claims") for
liability, damages, losses, costs and expenses (including the costs and expenses
of attorneys and other professionals), at both trial and appellate levels,
relating to the distribution, testing, manufacture, use, lease, sale,
consumption on or application of Licensed Products by PPDI, its Affiliates or
its Sublicensees pursuant to this Agreement, including, without limitation,
claims for any loss, damage, or injury to persons or property, or loss of life,
relating to the promotion and advertising of Licensed Products and/or
interactions and communications with governmental authorities, physicians or
other Third Parties relating to the Licensed Products. The foregoing
indemnification shall not apply to any Third Party Claims to the extent are
caused by the negligence of BDSI.

8.2 Indemnification by BDSI. BDSI shall defend, indemnify and hold PPDI, its
    -----------------------
officers, directors, employees and consultants harmless from and against any and
all Third Party Claims for liability, damages, losses, costs and expenses
(including the costs and expenses of attorneys and other professionals), at both
trial and appellate levels, relating to BDSI's activities contemplated under
this Agreement, including, but not limited to, (a) breach of the
representations, warranties and obligations of BDSI hereunder, or (b) any tax,
duty, levy or government imposition on any sums payable by PPDI to BDSI
hereunder. The foregoing indemnification shall not apply to any Claims to the
extent caused by the negligence of PPDI.

8.3 Notice. In the event that either Party seeks indemnification under Sections
    ------
8.1 or 8.2, the Party seeking indemnification agrees to (i) promptly inform the
other Party of the Third Party Claim, (ii) permit the other Party to assume
direction and control of the defense or claims resulting therefrom (including
the right to settle it at the sole discretion of that Party), and (iii)
cooperate as reasonably requested (at the expense of that Party) in the defense
of the Claim.

                                       12
<PAGE>

8.4 Insurance.
    ---------

          (a) Prior to the first human clinical trials of a Licensed Product
     under this Agreement, PPDI shall obtain and maintain broad form
     comprehensive general liability insurance and Licensed Products liability
     insurance with a reputable and financially secure insurance carrier, to
     cover such activities of PPDI and PPDI's contractual indemnity under this
     Agreement. Such insurance shall provide minimum annual limits of liability
     of $1,000,000.00 per occurrence and $3,000,000 in the aggregate with
     respect to all occurrences being indemnified under this Agreement. Such
     insurance policy shall be purchased and kept in force for the period of
     five (5) years after the cessation of sales of all Licensed Products under
     this Agreement.

          (b) In the event that PPDI chooses to rely on any strategic partners
     of PPDI to satisfy any of the requirements for insurance under this Section
     8.3, then PPDI shall provide details of such coverage to BDSI for its
     information. Any such coverage must substantially comply with the form,
     scope and amounts set forth in this Section 8.3(a) which are applicable to
     such insurance. In the event that any such insurance is a self-insured
     plan, PPDI shall determine that such strategic partner's self-insured plan
     is adequate given the financial condition of such strategic partner. At
     BDSI's request, which shall not be more frequently than annually, PPDI
     shall provide BDSI with a certificate of such insurance or written
     verification by such strategic partner of such self-insurance.

          (c) At BDSI's request, which shall not be more frequently than
     annually, PPDI shall provide BDSI evidence of any insurance obtained
     pursuant to Section 8.3(a). PPDI shall not, and shall not permit any
     strategic partner to, cancel or materially reduce the coverage of any
     policy of insurance required under this Section 8.3(a) without giving BDSI
     thirty (30) days prior written notice thereof.

                          ARTICLE 9 - TERM; TERMINATION

9.1 Term. This Agreement shall commence as of the Effective Date and, unless
    ----
sooner terminated as provided hereunder, shall terminate as to each Licensed
Product and as to each country in the Territory, upon the expiration of the last
to expire Valid Claim of a Licensed Patent necessary for the manufacture, use or
sale of such Licensed Product in such country.

9.2 Breach. Failure by either Party to comply with any of the material
    ------
obligations contained in this Agreement shall entitle the other Party to give to
the Party in default notice specifying the nature of the default and requiring
it to cure such default. If such default is not cured within sixty (60) days
after the receipt of such notice (or, if such default cannot be cured within
such sixty (60) day period, if the Party in default does not commence and
diligently continue actions to cure such default), the notifying Party shall be
entitled, without prejudice to any of its other rights conferred on it by this
Agreement, in addition to any other remedies available to it by law or in
equity, to terminate this Agreement by giving written notice to take effect
within thirty (30) days after such notice unless the defaulting Party shall cure
such default within said thirty (30) days. The right of either Party to
terminate this Agreement, as hereinabove provided, shall not be affected in any
way by its waiver or failure to take action with respect to any previous
default.

9.3 Termination by PPDI. PPDI shall have the right to terminate the licenses
    -------------------
granted herein, in whole or as to any Licensed Product in any country in the
Territory, at any time, and from time to time, by giving notice in writing to
BDSI. Such termination shall be effective thirty (30) days from the date such

                                       13
<PAGE>

notice is given, and all PPDI's rights associated therewith shall cease as of
that date, subject to Section 9.4.

9.4 Rights to Sell Stock on Hand. Upon the termination of any license granted
    ----------------------------
herein, in part or in whole or as to any Licensed Product, for any reason other
than a failure to cure a material breach of the Agreement by PPDI, PPDI shall
have the right for one (1) year or such longer period as the Parties may
reasonably agree to dispose of all Components or substantially completed
Components then on hand to which such termination applies, and Running Royalties
shall be paid to BDSI with respect to such Components as though this Agreement
had not terminated.

9.5 Termination of Sublicenses. Upon any termination of this Agreement, all
    --------------------------
sublicenses granted by PPDI under this Agreement shall terminate simultaneously,
subject, nevertheless, to Section 9.4.

9.6 Effect of Termination. Upon the termination of any license granted herein as
    ---------------------
to any Licensed Product in any country in the Territory other than pursuant to
Section 9.1, PPDI and its Affiliates and Sublicensees shall promptly: (i) return
to BDSI all relevant records, materials or confidential information of BDSI
concerning the Licensed Technology relating to such Licensed Product in such
country in the possession or control of PPDI or any of its Affiliates or
Sublicensees; and (ii) assign to BDSI, or BDSI's designee, its registrations
with governmental health authorities, licensees, and approvals of such Licensed
Product in such country.

9.7 Surviving Rights. Termination of this Agreement shall not terminate PPDI's
    ----------------
obligation to pay all Running Royalties which shall have accrued hereunder. The
Parties' obligations under Articles 7, 8 and 9 and Sections 11.6 and 11.10 shall
survive termination.

9.8 Accrued Rights, Surviving Obligations. Termination, relinquishment or
    --------------------------------------
expiration of this Agreement for any reason shall be without prejudice to any
rights which shall have accrued to the benefit of either Party under this
Agreement prior to such termination, relinquishment or expiration. Such
termination, relinquishment or expiration shall not relieve either Party from
obligations which are expressly indicated to survive termination or expiration
of this Agreement.

                        ARTICLE 10 - SUPPLIES OF MATERIAL

10.1 BDSI Supply Requirements. ***. CONFIDENTIAL TREATMENT REQUESTED
     ------------------------

10.2 Assistance in Third Party Contractor Identification. In the event that BDSI
     ---------------------------------------------------
desires to use a Third Party contractor for supply of cochleates, cochleate
derivatives, proteoliposomes or Component Product, BDSI shall obtain PPDI's
prior written approval for use of such Third Party contractor, the approval of
which shall not be unreasonably withheld.

                      ARTICLE 11 - MISCELLANEOUS PROVISIONS

11.1 Relationship of Parties. Nothing in this Agreement is or shall be deemed to
     -----------------------
constitute a partnership, agency, employee or joint venture relationship between
the Parties. No Party shall incur any debts or make any commitments for the
other, except to the extent, if at all, specifically provided herein.

11.2 Assignment. Except as otherwise provided herein, neither this Agreement nor
     ----------
any interest hereunder shall be assignable by any Party without the prior

                                       14
<PAGE>

written consent of the other; provided, however, that either Party may assign
this Agreement to any wholly-owned subsidiary or to any successor by merger or
sale of substantially all of its assets to which this Agreement relates in a
manner such that the assignor shall remain liable and responsible for the
performance and observance of all its duties and obligations hereunder. This
Agreement shall be binding upon the successors and permitted assigns of the
parties and the name of a Party appearing herein shall be deemed to include the
names of such Party's successors and permitted assigns to the extent necessary
to carry out the intent of this Agreement. Any assignment not in accordance with
this Section 10.2 shall be void.

11.3 Further Actions. Each Party agrees to execute, acknowledge and deliver such
     ---------------
further instructions, and to do all such other acts, as may be necessary or
appropriate in order to carry out the purposes and intent of this Agreement.

11.4 Force Majeure. Neither Party shall be liable to the other for loss or
     -------------
damages nor shall have any right to terminate this Agreement for any default or
delay attributable to any act of God, flood, fire, explosion, strike, lockout,
labor dispute, shortage of raw materials, casualty, accident, war, revolution,
civil commotion, act of public enemies, blockage or embargo, injunction, law,
order, proclamation, regulation, ordinance, demand or requirement of any
government or subdivision, authority or representative of any such government,
or any other cause beyond the reasonable control of such Party, if the Party
affected shall give prompt notice of any such cause to the other Party. The
Party giving such notice shall thereupon be excused from such of its obligations
hereunder as it is thereby disabled from performing for so long as it is so
disabled and for thirty (30) days thereafter. Notwithstanding the foregoing,
nothing in this Section 10.4 shall excuse or suspend the obligation to make any
payment due hereunder in the manner and at the time provided.

11.5 No Trademark Rights. Except as otherwise provided herein, no right, express
     -------------------
or implied, is granted by this Agreement to use in any manner the name "PPDI" or
"BDSI" or any other trade name or trademark of the other party in connection
with the performance of this Agreement.

11.6 Public Announcements. Except as required by law, neither Party shall make
     --------------------
any public announcement concerning this Agreement or the subject matter hereof
without the prior written consent of the other. In the event of a required
public announcement, the Party making such announcement shall provide the other
with a copy of the proposed text prior to such announcement.

11.7 Notices. Any notice required or permitted to be given or delivered
     -------
hereunder or by reason of the provisions of this Agreement shall be in writing
and shall be deemed to have been properly served if: (a) delivered personally,
(b) delivered by a recognized overnight courier service instructed to provide
next-day delivery, (c) sent by certified or registered mail, return receipt
requested and first class postage prepaid, or (d) sent by facsimile transmission
followed by confirmation copy delivered by a recognized overnight courier
service the next day. Such notices, demands and other communications shall be
sent to the addresses set forth below, or to such other addresses or to the
attention of such other person as the recipient Party has specified by prior
written notice to the sending Party. Date of service of such notice shall be:
(i) the date such notice is personally delivered or sent by facsimile
transmission (with issuance by the transmitting machine of confirmation of
successful transmission), (ii) three days after the date of mailing if sent by
certified or registered mail, or (iii) one day after date of delivery to the
overnight courier if sent by overnight courier. Unless otherwise specified in
writing, the mailing addresses of the Parties shall be as described below:

                                       15
<PAGE>

              (a)   If to BDSI, addressed to:

                    BioDelivery Sciences International, Inc.
                    185 South Orange Avenue, Administrative Building No. 4,
                    Newark, NJ 07103
                    Telephone No.:
                    Fax No.:

                    with a copy to the following:

                    Ellenoff Grossman Schole & Cyruli, LLP
                    370 Lexington Avenue
                    New York, NY 10017
                    Telephone No.: (212) 370-1300
                    Fax No.: (212) 370-7889

                    Attn: Barry I. Grossman, Esq.
                           Douglas S. Ellenoff, Esq.

               (b)  If to PPDI, addressed to:

                    Pharmaceutical Product Development, Inc.
                    3151 South Seventeenth Street
                    Wilmington, NC 28412
                    Attn:  Chief Executive Officer
                    Telephone No.: 910-772-6881
                    Fax No.: 910-343-5920

                    with a copy to each of the following:
                    General Counsel
                    3151 South Seventeenth Street
                    Wilmington, NC 28412
                    Telephone No.:  910-772-6829
                    Fax No.: 910-772-6951

11.8 Amendment. No amendment, modification or supplement of any provision of
     ---------
this Agreement shall be valid or effective unless made in writing and signed by
a duly authorized officer of each Party. This Agreement may be executed in a
series of counterparts, all of which, when taken together, shall constitute one
and the same instrument.

11.9 Waiver. No provision of this Agreement shall be waived by any act, omission
     ------
or knowledge of a Party or its agents or employees except by an instrument in
writing expressly waiving such provision and signed by the waiving Party.

11.10 Governing Law. This Agreement shall be governed by and interpreted in
      -------------
accordance with the laws of the State of orth Carolina.

                                       16
<PAGE>

11.11 Severability. Whenever possible, each provision of this Agreement will be
      ------------
interpreted in such manner as to be effective and valid under applicable law,
but if any provision of this Agreement is held to be prohibited by or invalid
under applicable law, such provision will be ineffective only to the extent of
such prohibition or invalidity, without invalidating the remainder of this
Agreement.

11.12 Entire Agreement of the Parties. This Agreement constitutes and contains
      -------------------------------
the entire understanding and agreement of the Parties and cancels and supersedes
any and all prior negotiations, correspondence, understandings and agreements,
whether oral or written, between the Parties respecting the subject matter
hereof.

                        [NEXT PAGE IS THE SIGNATURE PAGE]

                                       17
<PAGE>

         IN WITNESS WHEREOF, each of the Parties has caused this Agreement to be
executed by its duly authorized officer as of the day and year first above
written.

                               BIODELIVERY SCIENCES INTERNATIONAL, INC.

                               By:   /s/ Francis E. O'Donnell, Jr
                                  ---------------------------------------------
                                        Name:  Francis E. O'Donnell, Jr., M.D.
                                        Title:   President and CEO

                               PHARMACEUTICAL PRODUCT DEVELOPMENT, INC.

                               By:    /s/ Fred N. Eshelman
                                  ---------------------------------------------
                                        Name:    Fred N. Eshelman
                                        Title:   Vice Chairman and CEO

                                       S-1

<PAGE>

                                    EXHIBIT A

                              EVALUATION AGREEMENT

<PAGE>

                                    EXHIBIT B

                                LICENSED PATENTS

United States Patent Number 4,663,161, entitled "Liposome Methods and
Compositions", issued May 5, 1987

United States Patent Number 4,871,488, entitled "ReconstitutingViral
Glycoproteins Into Large Phospholipids Vesicles, issued October 3, 1989

United States Patent Number 5,643,574, entitled "Protein- or Peptide- Cochleate
Immunotherapeutics and Methods of Immunizing Using the Same", issued July 1,
1997.

United States Patent Number 5,834,015, entitled "Protein-lipid Vesicles and
Autogenous Immunotherapeutic Comprising the Same", issued November 10, 1998.

United States Patent Number 5,840,707, entitled "Stabilizing and Delivery Means
of Biological Molecules", issued November 24, 1998.

United States Patent Number 5,994,318, entitled "New cochleate formulations,
useful for the delivery of biologically relevant molecules e.g. nutrients,
lipophilic drugs and enzymes", issued November 30, 1999.

United States Patent Number 6,153,217, entitled "New lipid-based cochleates
formed using a mixture of 2 polymers, useful for the delivery of e.g. drugs,
polynucleotides, polypeptides or antigens", issued November 28, 2000.

United States Patent Number 6,165,502, entitled "Protein-lipid Vesicles and
Autogenous Immunotherapeutic Comprising the Same", issued December 26, 2000.

United States Patent Application Serial Number 08/130,986, filed October 4,
1993, corresponding to PCT Application No. PCT/US94/10913, filed September 30,
1994.

United States Patent Application Serial Number 08/394,70, filed February 22,
1995, corresponding to PCT Application No. PCT ___________________, filed
___________________.

European Patent No. EP 0722338, entitled "Protein- and Peptide Cochleate
Vaccines Methods of Immunizing Using the Same", granted July 25, 2001.

Australian Patent No. 722647, entitled "Protein-lipid Vesicles and Autogenous
Immunotherapeutic Comprising the Same", granted November 23, 2000.

Australian Patent No. 689505, entitled "Protein- or Peptide- Cochleate
Immunotherapeutics and Methods of Immunizing Using the Same", granted February
2, 1998

PCT Patent Publication No. WO 200042989, entitled "New lipid-based cochleates
formed using a mixture of 2 polymers, useful for the delivery of e.g. drugs,
polynucleotides, polypeptides or antigens"

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European Patent Application No. EP 1143933, entitled "New lipid-based cochleates
formed using a mixture of 2 polymers, useful for the delivery of e.g. drugs,
polynucleotides, polypeptides or antigens"

Australian Patent Application No. 200032133, entitled "New lipid-based
cochleates formed using a mixture of 2 polymers, useful for the delivery of e.g.
drugs, polynucleotides, polypeptides or antigens"

PCT Patent Publication No. WO 200152817, entitled "Cochleate composition useful
in preparation of a nutrient or flavor substance comprises biologically relevant
molecule, a negatively charged first lipid and a divalent cation or higher
valent cation"

Australian Patent Application No. 200131114, entitled "Cochleate composition
useful in preparation of a nutrient or flavor substance comprises biologically
relevant molecule, a negatively charged first lipid and a divalent cation or
higher valent cation"

PCT Patent Publication No. WO 9730725, entitled "New cochleate formulations,
useful for the delivery of biologically relevant molecules e.g. nutrients,
lipophilic drugs and enzymes"

Canadian Patent Application No. 2246754, entitled "New cochleate formulations,
useful for the delivery of biologically relevant molecules e.g. nutrients,
lipophilic drugs and enzymes"

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                                    EXHIBIT C

                               LICENSED TECHNOLOGY

I. COCHLEATE TECHNOLOGY

Origin of cochleates
Over the years, biochemists and biophysicists have studied artificial membrane
systems to understand their properties and potential applications. In studying
this topic, Demetrios Papahadjopoulos and coworkers began investigating the
interactions of divalent cations with negatively charged lipid bilayers. They
reported that the addition of calcium ions to small phosphatidylserine vesicles
induced their collapse into discs which fused into large sheets of lipid. In
order to minimize their interaction with water, these lipid sheets rolled up
into jellyroll-like structures, termed "cochleate" cylinders, after the Greek
name for a snail with spiral shell.

The Cochleate Advantage
Cochleate delivery vehicles represent a new technology platform for oral and
systemic delivery of clinically important drugs that possess poor
bioavailability. For example, oral cochleates have been successfully used in
animal models for the delivery of drugs that previously were only available
given by injection.

High stability: Cochleate delivery vehicles are stable phospholipids-divalent
cation precipitates composed of simple, naturally occurring materials, for
example, phosphatidylserine and calcium. They have a unique multilayered
structure consisting of a large, continuous, solid, lipid bilayer sheet rolled
up in a spiral, with no internal aqueous space. Cochleates can be stored in a
cation-containing buffer, or lyophilized to a powder and stored at room
temperature. Lyophilized cochleates can be placed in capsules and given orally,
or reconstituted with liquid prior to in vitro use or in vivo administration.
Lyophilization has no adverse effects on cochleate morphology or functions.
Cochleate preparations have been shown to be stable for more than two years at
4(degree)C in a cation-containing buffer, and at least one year as a lyophilized
powder at room temperature. Encochleation imparts increased stability to drugs,
proteins and polynucleotides.

Encapsulation: Cochleate delivery vehicles "wrap-up" or encapsulate the drug,
rather than chemically bond with the included drug.

Target delivery: Cochleates carry the encapsulated drug within the interior of
the formulation and delivery the drug to the target cell. This results in low
blood levels of free drug and high efficiency delivery to the target cell. Once
at the target cell, cochleates can be envisioned as membrane fusion
intermediates. When a cochleate comes into close approximation to a target
membrane, a fusion event between the outer layer of the cochleate and the cell
membrane occurs. This fusion results in the delivery of a small amount of the
encochleated material into the cytoplasm of the target cell. The cochleate may
slowly fuse or break free of the cell and be available for another fusion event,
either with this or another cell. Cochleates may also be taken up by
endocytosis, and fuse from within endocytic vesicles.

Resistance to environmental attack: The unique structure of the cochleate
provides protection from degradation for associated "encochleated" molecules.
Traditionally, many drugs can be damaged from exposure to adverse environmental
conditions such as sunlight, oxygen, water and temperature. Since the entire

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cochleate structure is a series of solid layers, components within the interior
of the cochleate structure remain intact, even though the outer layers of the
cochleate may be exposed to harsh environmental conditions or enzymes.

Oral availability: The drug delivery technology is being developed to enable
oral availability of a broad spectrum of compounds, such as those with poor
water solubility, as well as polynucleotides, and protein and peptide
biopharmaceuticals, which have been difficult to formulate and administer.

Release characteristics: The cochleate technology offers the potential to be
tailored to control the release of the drug depending on the desired
application.

Formulation of Cochleates
BDSI scientists have investigated various aspects of the manufacturing process,
including pH, agitation method and rate, type of cation, ratio of lipid to
material, and other parameters, in order to optimize the formulation and
manufacturing process for a given material. In one typical manufacturing
process, the materials to be formulated (chemical drugs, proteins, peptides,
DNA, antigens, nutrients) are added to a suspension of liposomes comprised
mainly of negatively charged lipids. The addition of divalent metal ions such as
calcium, (although other multivalent cations can be used) induces the collapse
and fusion of the liposomes into large sheets composed of lipid bilayers, which
spontaneously roll up or stack into cochleates. If desired, the cochleates can
be purified to remove unencochleated material, and then resuspended in a buffer
containing divalent metal ions.

Various processes have been developed by BDSI scientists to prepare cochleate
formulations of a wide variety of drugs, peptides and proteins, with molecular
weights ranging from 1 to greater than 200KD, and oligonucleotides or DNA of 20
to greater than 10,000 base pairs. The percentage of encochleation of material
ranges from 40-95%, depending on the material and the manufacturing conditions.

Biocompatibility of Cochleate Vehicles
The fundamental components of the cochleate delivery vehicle are
phosphatidylserine (PS) and calcium. Phosphatidylserine is a natural component
of all biologic membranes, and is most concentrated in the brain. Clinical
studies by other investigators, (more than 30 have been published), to evaluate
the potential of phosphatidylserine as a nutrient supplement indicate that PS is
very safe and may play a role in the support of mental functions in the aging
brain. Indeed, phosphatidylserine isolated from soy beans is sold in health food
stores as a nutritional supplement.

In mice, BDSI has evaluated the in vivo safety of multiple administrations of
cochleates by various routes, including intravenous, intraperitoneal, intranasal
and oral. Multiple administrations of cochleate formulations to the same animal
do not result in either the development of an immune response to the cochleate
matrix, or to any side effects relating to the cochleate vehicle.

Mechanism of Delivery
The interaction of calcium with negatively charged lipids has been extensively
studied. Many naturally occurring membrane fusion events involve the interaction
of calcium with negatively charged phospholipids (generally phosphatidylserine
and phosphatidylglycerol). Calcium induced perturbations of membranes containing
negatively charged lipids, and the subsequent membrane fusion events, are
important mechanisms in many natural membrane fusion processes. Hence,
cochleates can be envisioned as membrane fusion intermediates.

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<PAGE>

During the past several years substantial research by BDSI scientists has
demonstrated that cochleate formulations are simple, safe and highly efficacious
mediators of the in vivo delivery of proteins, peptides and polynucleotides for
the induction of antigen specific immune responses following oral, intranasal
and intramuscular administration. Significantly, the ability of cochleates to
mediate the induction of antigen specific, CD8+ cytotoxic lymphocytes, as well
as the efficient induction of immune responses to plasmid encoded antigens,
supports the hypothesis that cochleates facilitate the cytoplasmic delivery of
cochleate associated bioactive molecules.

The observations indicate that, as the calcium rich, highly ordered membrane of
a cochleate first comes into close approximation to a natural membrane, a
perturbation and reordering of the cell membrane is induced. This results in a
fusion event between the outer layer of the cochleate and the cell membrane.
This fusion also results in the delivery of a small amount of the encochleated
material into the cytoplasm of the target cell. The cochleate may slowly fuse or
break free of the cell and be available for another fusion event, either with
this or another cell. Cochleates may also be taken up by endocytosis, and fuse
from within endocytic vesicles.

Uptake of Cochleates by Macrophage
An important observation relative to the interaction of cochleates with cells is
their uptake by macrophage. For example, in vivo, fluorescent cochleates are
accumulated by macrophage. Macrophages are on the first line of defense against
microbial infections. Many human pathogens cause diseases because they have
developed the capacity to survive within macrophage. Examples include viruses
such as HIV, bacteria such as staphylococcus and Mycobacterium tuberculosis,
fungi such as Candida and parasites such as Leishmania.

Cochleate Mediated Oral Delivery of Drugs
Cochleate formulation technology is particularly applicable to macromolecules as
well as small molecule drugs that are hydrophobic, positively, or negatively
charged, and possess poor oral bioavailability. Proof-of-principle studies for
cochleate mediated oral delivery of macromolecules as well as small molecule
drugs is being carried out in appropriate animal models with a well established,
clinically important drug which currently can only be effectively delivered by
injection, amphotericin B, a potent antifungal agent.

II.  PROTEOLIPOSOME TECHNOLOGY

Proteoliposome Technology (PLT), relates to novel liposome compositions and
methods for their preparation. Utilization of PLT provides an efficient
reconstitution of membrane proteins into large (0.1 to 2 micron diameter)
phospholipid vesicles with a large, internal aqueous space. The method has been
exemplified with the use of glycoproteins of influenza (A/PR8/34) and Sendai
(parainfluenza type I) viruses. The method comprises (A) extracting out the
desired membrane protein from a source biological material with an extraction
buffer comprising a detergent; (B) mixing the extract with a phospholipid
solution and deriving a cochleate intermediate; and (C) forming large
phospholipid vesicles with integrated membrane protein in a biologically active
state.

PLT has been used to produce liposome structures with improved delivery
capabilities for drug delivery and gene therapy as well as enhanced immune
responses. In addition, BDSI PLT can be used to formulate and stabilize
biologically important but structurally fragile hydrophobic proteins.
The PLT is protected by US Patent Nos. 4,663,161 and 4,871,488.

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