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                                                                   EXHIBIT 10.45

                          AMYLIN PHARMACEUTICALS, INC.

                    NON-EMPLOYEE DIRECTORS' STOCK OPTION PLAN

                           ADOPTED ON FEBRUARY 9, 1994

           AS AMENDED BY THE BOARD OF DIRECTORS ON NOVEMBER 14, 1995,
        FEBRUARY 8, 1996, MAY 29, 1997, MAY 20, 1998, OCTOBER 12, 1999,
      DECEMBER 8, 1999, APRIL 13, 2000, JUNE 1, 2000, AND FEBRUARY 8, 2001

1.    PURPOSE.

      (a)   The purpose of this Non-Employee Directors' Stock Option Plan (the
"Plan") is to provide a means by which each member of the Board of Directors of
Amylin Pharmaceuticals, Inc., a Delaware corporation (the "Company"), who is not
otherwise an employee of the Company or any Affiliate of the Company (each such
person being hereafter referred to as a "Non-Employee Director") will be given
an opportunity to purchase stock of the Company.

      (b)   The word "Affiliate" as used in the Plan means any parent
corporation or subsidiary corporation of the Company as those terms are defined
in Sections 424(e) and (f), respectively, of the Internal Revenue Code of 1986,
as amended (the "Code").

      (c)   The Company, by means of the Plan, seeks to retain the services of
persons now serving as Non-Employee Directors of the Company, to secure and
retain the services of persons capable of serving in such capacity, and to
provide incentives for such persons to exert maximum efforts for the success of
the Company.

      (d)   The Company intends that the options issued under the Plan not be
incentive stock options as that term is used in Section 422 of the Code.

2.    ADMINISTRATION.

      (a)   The Plan shall be administered by the Board of Directors of the
Company (the "Board") unless and until the Board delegates administration to a
committee, as provided in subparagraph 2(c).

      (b)   The Board shall have the power, subject to, and within the
limitations of, the express provisions of the Plan:

            (i)   To construe and interpret the Plan and options granted under
it, and to establish, amend and revoke rules and regulations for its
administration. The Board, in the exercise of this power, may correct any
defect, omission or inconsistency in the Plan or in any option agreement, in a
manner and to the extent it shall deem necessary or expedient to make the Plan
fully effective.

            (ii)  To amend the Plan as provided in paragraph 11.

                                       1.
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            (iii) Generally, to exercise such powers and to perform such acts as
the Board deems necessary or expedient to promote the best interests of the
Company.

      (c)   The Board may delegate administration of the Plan to a committee
composed of not fewer than two (2) members of the Board (the "Committee"). If
administration is delegated to a Committee, the Committee shall have, in
connection with the administration of the Plan, the powers theretofore possessed
by the Board, subject, however, to such resolutions, not inconsistent with the
provisions of the Plan, as may be adopted from time to time by the Board. The
Board may abolish the Committee at any time and revest in the Board the
administration of the Plan.

3.    SHARES SUBJECT TO THE PLAN.

      (a)   Subject to the provisions of paragraph 10 relating to adjustments
upon changes in stock, the stock that may be sold pursuant to options granted
under the Plan shall not exceed in the aggregate 450,000 shares of the Company's
common stock. If any option granted under the Plan shall for any reason expire
or otherwise terminate without having been exercised in full, the stock not
purchased under such option shall revert to and again become available for
issuance pursuant to exercises of options granted under the Plan.

      (b)   The stock subject to the Plan may be unissued shares or reacquired
shares, bought on the market or otherwise.

4.    ELIGIBILITY.

      Options shall be granted only to Non-Employee Directors of the Company.

5.    NON-DISCRETIONARY GRANTS.

      (a)   Each person who is, immediately following the Company's 1994 Annual
Meeting of Stockholders (the "1994 Annual Meeting") at which the Plan is
approved by the stockholders of the Company, a Non-Employee Director of the
Company shall be granted, effective as of the date of such Annual Meeting, an
option to purchase ten thousand (10,000) shares of common stock of the Company
on the terms and conditions set forth herein.

      (b)   Each person who is, subsequent to November 1, 1995, and on or prior
to May 29, 1997, elected for the first time by the Board or shareholders of the
Company to serve as a Non-Employee Director of the Company and who has not
previously served as a member of the Board shall be granted, effective as of the
date of such election, an option to purchase thirty thousand (30,000) shares of
common stock of the Company on the terms and conditions set forth herein. Each
person who is, subsequent to May 29, 1997, elected by the Board or shareholders
of the Company to serve as a Non-Employee Director of the Company and who has
not served as a member of the Board at any time during the two-year period
immediately preceding such election, shall be granted, effective as of the later
of December 8, 1999 and the date of such election, an option to purchase twenty
thousand (20,000) shares of common stock of the Company on the terms and
conditions set forth herein.

                                       2.
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      (c)   (i)   Commencing with the 1996 Annual Meeting of Stockholders and
ending with the 2000 Annual Meeting of Stockholders, each person who is,
immediately following each Annual Meeting of Stockholders of the Company that
occurs in an even year (i.e. 1996, 1998, 2000) (hereinafter, an "Even Year
Annual Meeting"), a Non-Employee Director of the Company shall be granted,
effective as of the date of such Even Year Annual Meeting (and in addition to
any option granted pursuant to Section 5(b)), an option to purchase ten thousand
(10,000) shares of common stock of the Company on the terms and conditions set
forth herein.

            (ii)  Commencing with the 2001 Annual Meeting of Stockholders, each
person who is: (1) immediately following the 2001 Annual Meeting of
Stockholders, a Non-Employee Director of the Company shall be granted, effective
as of the date of such 2001 Annual Meeting of the Stockholders (and in addition
to any option granted pursuant to Section 5(b)), an option to purchase three
thousand (3,000) shares of common stock of the Company pursuant to the terms and
conditions set forth herein; and (2) immediately following each Annual Meeting
of Stockholders of the Company subsequent to the 2001 Annual Meeting of
Stockholders, a Non-Employee Director of the Company shall be granted, effective
as of the date of such Annual Meeting of the Stockholders (and in addition to
any option granted pursuant to Section 5(b)), an option to purchase eight
thousand (8,000) shares of common stock of the Company pursuant to the terms and
conditions set forth herein.

6.    OPTION PROVISIONS.

      Each option shall contain the following terms and conditions:

      (a)   No option shall be exercisable after the expiration of ten (10)
years from the date it was granted.

      (b)   The exercise price of each option shall be equal to the Fair Market
Value (defined below) of the stock subject to such option on the date such
option is granted. For purposes of this Plan, "Fair Market Value" means, as of
any date, the value of the common stock of the Company determined as follows:

            (i)   If the common stock is listed on any established stock
exchange or a national market system, including without limitation the National
Market System or the SmallCap Market System of the National Association of
Securities Dealers, Inc. Automated Quotation ("NASDAQ") System, the fair market
value of a share of common stock shall be the closing sales price for such stock
(or the closing bid if no sales are reported) on such exchange or national
market system on the trading day on which the determination is to be made, as
reported in the Wall Street Journal or such other source as the Board deems
reliable;

            (ii)  If the common stock is quoted on the NASDAQ System (but not on
the National Market System or the SmallCap Market System thereof) or is
regularly quoted by a recognized securities dealer but selling prices are not
reported, the fair market value of a share of common stock shall be the closing
sales price for such stock (or the closing bid if no sales are reported) on the
trading day on which the determination is to be made, as reported in the Wall
Street Journal or such other source as the Board deems reliable;

                                       3.
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            (iii) In the absence of an established market for the common stock,
the fair market value shall be determined in good faith by the Board.

      (c)   The purchase price of stock acquired pursuant to an option shall be
paid, to the extent permitted by applicable statutes and regulations, either (1)
in cash at the time the option is exercised, or (2) by delivery to the Company
of shares of common stock of the Company that have been held for the requisite
period necessary to avoid a charge to the Company's reported earnings and valued
at the Fair Market Value on the date of exercise, or (3) by a combination of
such methods of payment.

      (d)   An option shall not be transferable except by will or by the laws of
descent and distribution, and shall be exercisable during the lifetime of the
person to whom the option is granted only by such person or by his guardian or
legal representative.

      (e)   Options granted pursuant to the Plan shall vest as follows:

            (i)   An option granted pursuant to Section 5(a) or 5(c)(i) shall
vest with respect to each optionee over a period of two (2) years with
0.1369863% of the total number of shares subject to such option vesting on each
day following the date of grant of such option (provided that the grantee has,
during the entire period prior to any such vesting date, continuously served as
a Non-Employee Director), whereupon such option shall become fully exercisable
in accordance with its terms with respect to the shares vesting as of such date.

            (ii)  An option granted pursuant to Section 5(b) shall vest
according to the following schedule:

      If the optionee continues as a Non-Employee Director of the Company or any
Affiliate of the Company through the date that is one (1) year from the date of
grant thereof ("Anniversary Date"), such option shall become exercisable as of
the Anniversary Date with respect to one-fourth (1/4th) of the total number of
shares subject to such option.

      Thereafter, for so long as such optionee continues as a Non-Employee
Director of the Company or an Affiliate of the Company, such option will become
exercisable with respect to an additional .0684932% of the total number of
shares subject to such option for each day subsequent to the Anniversary Date
until such option has become fully exercisable.

      Notwithstanding the foregoing, in no event shall fractional shares be
issuable upon any such exercise, and in lieu of any such fractional share, the
Company shall pay cash to the holder of such option equal to the Fair Market
Value thereof.

            (iii) Each option granted pursuant to Section 5(c)(ii) shall vest
over a period of one (1) year from the date of grant of such option in equal
monthly installments for so long as the optionee continues as a Non-Employee
Director of the Company or an Affiliate of the Company until such option has
become fully exercisable."

      (f)   The option shall include a provision whereby the optionee may elect,
at any time during the period in which the optionee continues as a Non-Employee
Director of the Company or an Affiliate of the Company, to exercise the option
as to any or all of the shares of common

                                       4.
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stock subject to the option prior to the full vesting of the option. Any
unvested shares of common stock so purchased shall be subject to a repurchase
option in favor of the Company, with a vesting schedule which corresponds to the
vesting schedule applicable to such unvested shares, in such form as the Board
determines to be appropriate.

      (g)   The Company may require any optionee, or any person to whom an
option is transferred under subparagraph 6(d), as a condition of exercising any
such option: (1) to give written assurances satisfactory to the Company as to
the optionee's knowledge and experience in financial and business matters; and
(2) to give written assurances satisfactory to the Company stating that such
person is acquiring the stock subject to the option for such person's own
account and not with any present intention of selling or otherwise distributing
the stock. These requirements, and any assurances given pursuant to such
requirements, shall be inoperative if (i) the issuance of the shares upon the
exercise of the option has been registered under a then-currently-effective
registration statement under the Securities Act of 1933, as amended (the
"Securities Act"), or (ii), as to any particular requirement, a determination is
made by counsel for the Company that such requirement need not be met in the
circumstances under the then-applicable securities laws.

      (h)   Notwithstanding anything to the contrary contained herein, an option
may not be exercised unless the shares issuable upon exercise of such option are
then registered under the Securities Act or, if such shares are not then so
registered, the Company has determined that such exercise and issuance would be
exempt from the registration requirements of the Securities Act.

7.    COVENANTS OF THE COMPANY.

      (a)   During the terms of the options granted under the Plan, the Company
shall keep available at all times the number of shares of stock required to
satisfy such options.

      (b)   The Company shall seek to obtain from each regulatory commission or
agency having jurisdiction over the Plan such authority as may be required to
issue and sell shares of stock upon exercise of the options granted under the
Plan; provided, however, that this undertaking shall not require the Company to
register under the Securities Act either the Plan, any option granted under the
Plan, or any stock issued or issuable pursuant to any such option. If the
Company is unable to obtain from any such regulatory commission or agency the
authority which counsel for the Company deems necessary for the lawful issuance
and sale of stock under the Plan, the Company shall be relieved from any
liability for failure to issue and sell stock upon exercise of such options.

      (c)   Effective as of June 1, 1998, the Company shall not implement
without prior stockholder approval any stock option exchange program or
repricing program intended to reduce the exercise price applicable to options
granted pursuant to the Plan. This subsection 7(c) may not be amended or
modified by the Company without prior stockholder approval.

8.    USE OF PROCEEDS FROM STOCK.

      Proceeds from the sale of stock pursuant to options granted under the Plan
shall constitute general funds of the Company.

                                       5.
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9.    MISCELLANEOUS.

      (a)   Neither an optionee nor any person to whom an option is transferred
under subparagraph 6(d) shall be deemed to be the holder of, or to have any of
the rights of a holder with respect to, any shares subject to such option unless
and until such person has satisfied all requirements for exercise of the option
pursuant to its terms.

      (b)   Nothing in the Plan or in any instrument executed pursuant thereto
shall confer upon any Non-Employee Director any right to continue in the service
of the Company or any Affiliate or shall affect any right of the Company, its
Board or stockholders or any Affiliate to terminate the service of any
Non-Employee Director with or without cause and with or without notice.

      (c)   No Non-Employee Director, individually or as a member of a group,
and no beneficiary or other person claiming under or through him, shall have any
right, title or interest in or to any option reserved for the purposes of the
Plan except as to such shares of common stock, if any, as shall have been
reserved for him pursuant to an option granted to him.

      (d)   In connection with each option made pursuant to the Plan, it shall
be a condition precedent to the Company's obligation to issue or transfer shares
to a Non-Employee Director, or an affiliate of such Non-Employee Director, or to
evidence the removal of any restrictions on transfer, that such Non-Employee
Director make arrangements satisfactory to the Company to insure that the amount
of any federal or other withholding tax required to be withheld with respect to
such sale or transfer, or such removal or lapse, is made available to the
Company for timely payment of such tax.

10.   ADJUSTMENTS UPON CHANGES IN STOCK.

      (a)   If any change is made in the stock subject to the Plan, or subject
to any option granted under the Plan (through merger, consolidation,
reorganization, recapitalization, stock dividend, dividend in property other
than cash, stock split, liquidating dividend, combination of shares, exchange of
shares, change in corporate structure or otherwise) (individually, a
"Capitalization Adjustment"), the Plan and outstanding options will be
appropriately adjusted in the class(es) and maximum number of shares subject to
the Plan and the class(es) and number of shares and price per share of stock
subject to outstanding options.

      (b)   In the event of: (1) a dissolution or liquidation of the Company;
(2) a merger or consolidation in which the Company is not the surviving
corporation; (3) a reverse merger in which the Company is the surviving
corporation but the shares of the Company's common stock outstanding immediately
preceding the merger are converted by virtue of the merger into other property,
whether in the form of securities, cash or otherwise; or (4) any other capital
reorganization in which more than fifty percent (50%) of the shares of the
Company entitled to vote are exchanged, then to the extent permitted by
applicable law (individually, a "Change in Control"), the time during which such
options may be exercised shall be accelerated and the options terminated if not
exercised prior to such event.

                                       6.
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11.   AMENDMENT OF THE PLAN.

      (a)   The Board at any time, and from time to time, may amend the Plan.
Except as provided in paragraph 10 relating to adjustments upon changes in
stock, no amendment shall be effective unless approved by the stockholders of
the Company within twelve (12) months before or after the adoption of the
amendment, where the amendment will:

            (i)   Increase the number of shares reserved for options under the
Plan; or

            (ii)  Modify the Plan in any other way if such modification requires
stockholder approval in order for the Plan to comply with the requirements of
Rule 16b-3 promulgated under the Exchange Act or Section 162(m) of the Code.

      (b)   Rights and obligations under any option granted before any amendment
of the Plan shall not be altered or impaired by such amendment of the Plan
unless (i) the Company requests the consent of the person to whom the option was
granted and (ii) such person consents in writing.

12.   TERMINATION OR SUSPENSION OF THE PLAN.

      (a)   The Board may suspend or terminate the Plan at any time. Unless
sooner terminated, the Plan shall terminate on February 8, 2004. No options may
be granted under the Plan while the Plan is suspended or after it is terminated.

      (b)   Rights and obligations under any option granted while the Plan is in
effect shall not be altered or impaired by suspension or termination of the
Plan, except with the consent of the person to whom the option was granted.

13.   EFFECTIVE DATE OF PLAN; CONDITIONS OF EXERCISE.

      (a)   The Plan shall become effective upon adoption by the Board of
Directors, subject to the condition subsequent that the Plan is approved by the
stockholders of the Company in accordance with Rule 16-b(3)(1) of the
Regulations under the Securities Exchange Act prior to June 30, 1994.

      (b)   No option granted under the Plan shall be exercised or exercisable
unless and until the condition of subparagraph 13(a) above has been met.

                                       7.EX- 10.2

                          Agreement

     Reference is made to the Restructuring Agreement between
DIONICS, INC. and APPLE BANK FOR SAVINGS dated as of January
31, 1994 (the "Restructuring Agreement").  Capitalized terms
used in this Agreement shall have the meanings assigned to
those terms in the Restructuring Agreement.

     WHEREAS, in connection with the Restructuring Agreement,
Dionics executed and delivered Restructuring Documents to the
Bank;

     WHEREAS, all of the Bank's rights under the
Restructuring Agreement and the Restructuring Documents have
been assigned to D.A.N. Joint Venture, a Limited Partnership
("D.A.N.");

     WHEREAS, certain issues have arisen subsequent to the
Interim Maturity Date with respect to the payment of principal
and interest under Term Loan A and Term Loan C;

     WHEREAS, the parties have agreed to resolve such issues
as hereinafter set forth;

     NOW, THEREFORE, the parties hereby covenant and agree as
follows:

     1.    D.A.N. represents and warrants that it is the
lawful ultimate assignee of the Bank with respect to all of the
Bank's rights under the Restructuring Agreement and the
Restructuring Documents and with respect to all of the
outstanding indebtedness of Dionics as reflected therein.  None
of such interests has been transferred or otherwise encumbered
and no other party has any rights with respect thereto.

     2.   The parties acknowledge and agree that the total
unpaid accrued interest on Term Loan A and Term Loan C is in
the aggregate amount of $86,096.13 as of June 30, 2001 (the
"Aggregate Accrued Interest").  Dionics hereby agrees to
immediately pay, and D.A.N. agrees to accept, the sum of
$57,500.00 in full and complete settlement and discharge of the
Aggregate Accrued Interest.

     3.   The parties hereby acknowledge and agree that as
of the date hereof the principal balance owing on Term Loan A
is in the amount of $151,386.76 (the "Term Loan A Principal
Balance") and the principal balance owing on Term Loan C is in
the amount of $89,335.20 (the "Term Loan C Principal Balance").
The Term Loan A Principal Balance shall be paid in 32
consecutive monthly installments of $4,730.83 each commencing
August 1, 2001 and until the Term Loan A Principal Balance is
paid in full.  The Term Loan C Principal Balance shall be paid
in 32 consecutive monthly installments of $2,791.67 each
commencing August 1, 2001 and until the Term Loan C Principal
Balance is paid in full.   In addition, (a) interest on the
Term Loan A Principal Balance  will begin to accrue as of July
3, 2001 at the rate per annum set forth in Replacement Note A
and, commencing August 1, 2001 and until the Term Loan A
Principal Balance is paid in full, interest shall be paid
monthly in arrears on the then outstanding principal balance
thereof; and (b)  interest on the Term Loan C Principal Balance
will begin to accrue as of July 3, 2001 at the rate per annum
set forth in Replacement Note C and, commencing August 1, 2001
and until the Term Loan C Principal Balance is paid in full,
interest shall be paid monthly in arrears on the then
outstanding principal balance thereof.

     4.   This Agreement may be executed in counterparts,
each of which shall be deemed an original but all of which
together shall constitute one and the same instrument.  This
Agreement shall become effective upon the execution and
delivery by all parties hereto of this Agreement (or
counterpart thereof) and shall not be binding upon any party
executing this Agreement (or counterpart thereof) until
executed by all parties hereto.

     5.   Except as modified herein, Dionics further
reaffirms and acknowledges its continuing obligation under the
Restructuring Agreement.

     IN WITNESS WHEREOF, the parties hereto have executed and
delivered the foregoing Agreement on this 11th day of July,
2001.

               D.A.N. Joint Venture,
               a Limited Partnership,
               by its General Partner,
                              Cadle Company of Ohio Inc.

               By:    /s/ William E. Shaulis
               Name:  William E. Shaulis
               Title: Executive Vice President

               Dionics, Inc.

               By:    /s/ Bernard L. Kravitz
               Name:  Bernard L. Kravitz
               Title: President

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