Document:

<PAGE>   1
          Confidential Materials omitted and filed separately with the
        Securities and Exchange Commission. Asterisks denote omissions.

                                                                    EXHIBIT 10.6

                                LICENSE AGREEMENT
                                -----------------

     This Agreement, made and entered into this 6th day of June 1990, by and
between Biogen, Inc. a Massachusetts corporation, of 14 Cambridge Center,
Cambridge, MA 02142 ("BIOGEN") and Health Research, Inc., a not-for-profit
corporation of 1683 Empire State Plaza, Albany, New York 12237 ("HRI").

     WHEREAS, HRI is a co-owner with BIOGEN of the Licensed Patent Rights (as
herein defined); and

     WHEREAS, BIOGEN desires to become exclusively licensed to HRI's rights in
the Licensed Patent Rights.

     NOW, THEREFORE, for good and valuable consideration and upon the mutual
covenants and promises hereinafter set forth, the parties agree as follows:

1.   DEFINITIONS
     -----------

     1.1 "Affiliates" shall mean any corporation, partnership, or other business
organization which directly or indirectly controls, is controlled by, or is
under common control with BIOGEN. For purposes of this Agreement, "control"
shall mean the holding directly or indirectly of fifty percent (50%) or more of
the voting stock or other ownership interest of the corporation or business
entity involved.

     1.2 "Licensed Patent Rights" shall mean the co-owned BIOGEN and HRI patent
application listed in Exhibit A, attached hereto, and any foreign counterpart
patent applications and any patents which issue therefrom, together with any
extensions, reissues, renewals, divisions, continuations or
continuations-in-part thereof, and any other co-owned BIOGEN and HRI patent
applications or patents describing or arising out of the inventions covered by
the patent application listed in Exhibit A.

     1.3 "Licensed Product(s)" shall mean any product which falls within the
scope of a claim of the Licensed Patent Rights or is made in whole or in part in
accordance with a process which falls within the scope of a claim of the
Licensed Patent Rights.

     1.4 "Net Sales" shall mean the gross invoice price of Licensed Product(s)
sold in any country by BIOGEN or its Affiliates to any party other than
sublicensees, less deductions for (i) any sales taxes, excise taxes and duties,
(ii) packaging, shipping, handling and insurance charges, (iii) allowances and
adjustments for spoiled, damages, outdated or returned Licensed Product(s), and
(iv) trade discounts, to the extent such deductions are actually billed or
credited to the customer. Sales or transfers of Licensed Product(s) between
BIOGEN and its Affiliates shall not be deemed Net Sales unless BIOGEN or its
Affiliates are the end users of the Licensed Product(s).

     1.5 "Sublicense Income" shall mean the royalty income actually received by
BIOGEN or its Affiliates from the sale of Licensed Product(s) by BIOGEN's
sublicensees, less deductions for any withholding or other taxes. It is agreed
that royalty income shall not include payments BIOGEN or its Affiliates receive
from the supply of material, equipment, know-how,

<PAGE>   2
          Confidential Materials omitted and filed separately with the
        Securities and Exchange Commission. Asterisks denote omissions.

technical information and the like to BIOGEN's sublicensees, and shall not
include the sales or transfers of Licensed Product(s) between BIOGEN or its
Affiliates and the sublicensees unless the sublicensees are the end users of the
Licensed Product(s).

2.   LICENSE GRANT
     -------------

     2.1 Subject to the terms and conditions hereinafter set forth, HRI hereby
grants to BIOGEN and its Affiliates a worldwide license, with the right to grant
sublicenses, under the Licensed Patent Rights to make, have made, use, sell, and
have sold Licensed Product(s). Such license shall be exclusive except that HRI
reserves the right to use the Licensed Patent Rights for noncommercial research
and educational purposes.

3.   PAYMENTS
     --------

     3.1 In consideration for the contribution to the scientific and technical
developments relating to Licensed Products by the HRI, BIOGEN shall pay the
following non-refundable fees to HRI:

     (a) Five thousand U.S. Dollars $5,000  within thirty (30) days of execution
         of this Agreement.

     (b) Seven thousand five hundred U.S. dollars $7,500 within thirty (30) days
         of BIOGEN's submission of the first Investigational New Drug
         application to the United States Food and Drug Administration ("FDA")
         for a Licensed Product.

     (c) Fifteen thousand U.S. dollars $15,000 within thirty (30) days of
         Biogen's submission of the first New Drug Application to the FDA for a
         Licensed Product.

     (d) Twenty-five thousand U.S. dollars $25,000 within thirty (30) days of
         the FDA's approval of Biogen's first New Drug Application for a
         Licensed Product.

     3.2 In consideration for the rights granted by HRI to BIOGEN hereunder,
BIOGEN shall pay to HRI:

     (a) A minimum annual royalty of [**] U.S. dollars [**] beginning with the
         calendar year following the first sale of Licensed Product.

     (b) A royalty on the cumulative annual Net Sales of Licensed Product
         according to the following schedule:

         Cumulative Annual Net Sales                Royalty Percentage
         ---------------------------                ------------------

         [**] Million U.S. Dollars                          [**]
         [**] Million U.S. Dollars                          [**]
         [**] Million U.S. Dollars                          [**]
         [**] Million U.S. Dollars & Greater                [**]

                                       2

<PAGE>   3
          Confidential Materials omitted and filed separately with the
        Securities and Exchange Commission. Asterisks denote omissions.

     (c) A royalty of [**] of the Sublicense Income received by BIOGEN and its
Affiliates.

     3.3 BIOGEN shall be entitled to credit any minimum annual royalty paid to
HRI in a calendar year pursuant to Section 3.2(a) against any royalties earned
in that same calendar year and due to HRI pursuant to Section 3.2(b).

     3.4 Unless this Agreement is terminated pursuant to Article 9, BIOGEN
shall, within sixty (60) days after the last days of June and December in each
year during the term of this Agreement, provide HRI with an accounting of Net
Sales and/or Sublicense Income for the immediately preceding six (6) month
period (the Royalty Period). Further, BIOGEN shall provide HRI with an
accounting of the royalties due with respect to the preceding six (6) month
period and shall, at the time when it delivers such account, make payment of the
amount of royalty payment due under this Article 3.

     3.5 BIOGEN shall keep (or cause to be kept) and maintain complete and
accurate records of its Net Sales and Sublicense Income in accordance with
generally accepted accounting procedures. Such records shall be accessible for
review by HRI or by an independent certified public accountant selected and paid
for by HRI and acceptable to BIOGEN (which acceptance shall not be unreasonably
withheld), not more than once a year at any reasonable time during business
hours within one (1) year after the end of the royalty period to which such
records relate, for the purpose of verifying any royalty due thereon. The
individual conducting such review shall disclose to HRI only information
relating to the accuracy of the records kept and the payments made, shall be
under a duty to keep confidential any other information gleaned from such
records.

     3.6 All monies to be paid to HRI shall be made and computed in United
States Dollars, and BIOGEN shall use its reasonable efforts to convert royalty
payments payable on Net Sales and Sublicense income in any country foreign to
United States Dollars; provided, however, that if conversion to and transfer of
Dollars cannot be made by BIOGEN in any country for any reason, BIOGEN may pay
such sums in the currency of the country in which such sales are made, deposited
in HRI's name in a bank designated by HRI in any such country. The rate of
exchange of local currencies to United States Dollars shall be at the rate of
exchange in force on the last business day of the Royalty Period as reported by
The Wall Street Journal.

     3.7 If BIOGEN or its Affiliates or their sublicensees, in order to operate
under or exploit the licenses granted under Article 2 of this Agreement in any
country, is required to make any payment (including, but not limited to,
royalties, up-front payments, option fees or license fees) to one or more third
parties to obtain a license or similar right in the absence of which the
Licensed Products could not be used, manufactured or sold in such country
without violating the property, patent or other right of a third party, BIOGEN
may deduct from royalties otherwise payable to HRI an amount equal to such
payments made during the same Royalty Period to such third party, provided that
(a) the royalties paid to HRI for such Royalty Period shall not be reduced on
any payment date by more than [**] and (b) BIOGEN provides HRI with evidence,
reasonably satisfactory to HRI, of such third-party payments.

                                        3

<PAGE>   4

4.   COMMERCIALIZATION
     -----------------

     4.1 BIOGEN agrees to use reasonable commercial efforts to research and
develop, obtain regulatory approval and commercialize Licensed Product(s) in the
United States and agrees to provide HRI with written annual reports on such
efforts.

     4.2 BIOGEN shall not use the name of HRI, the New York State Department of
Health or New York State in any advertising or promotional sales literature
without the prior written consent of HRI, except that BIOGEN may state that it
is licensed by HRI under the Licensed Patents Rights.

5.   WARRANTIES
     ----------

     5.1 Each party represents and warrants that it has the full power and
authority to enter into this Agreement and that entering into this Agreement
does not breach any existing agreements already signed by that party.

     5.2 Nothing herein contained shall be construed by either party hereto as a
representation or warranty that the exercise of the licensed rights will not
constitute an infringement of the intellectual property rights of third parties.

     5.3 BIOGEN agrees that HRI shall have no responsibility, or liability with
respect to any Licensed Product and agrees to hold HRI, the New York State
Department of Health and New York State harmless from any and all damages,
losses, costs and expenses which they incur as a result of any action, claim or
demand as a result of activities by BIOGEN, its Affiliates and sublicensees
arising out of or relating to Licensed Product.

     5.4 BIOGEN, its Affiliates and its sublicensee(s) agree to comply with all
regulations and safety standards of government agencies such as the Consumer
Product Safety Act and the Food and Drug Act.

6.   PATENTS
     -------

     6.1 BIOGEN shall be responsible for, and bear the costs of, the filing,
prosecution, issuance, enforcement, defense and maintenance of the Licensed
Patent Rights, except as provided for in Section 6.2 below.

     6.2 BIOGEN and HRI shall promptly notify the other in writing of any actual
or threatened infringement of any Licensed Patent Rights, and shall at the same
time provide the other with any available evidence of infringement. The parties
shall then discuss what action, if any, each parties believes should be taken in
the matter.

     (a) In the event BIOGEN, alone or with an Affiliate or sublicensee, wishes
         to take action in a suit to enforce or defend any Licensed Patent
         Rights, BIOGEN may take action and, at its option, join HRI as a
         plaintiff. BIOGEN, alone or with its Affiliates and sublicensees,
         shall exercise control over such action and shall bear all costs
         thereof, including, but not limited to attorney's fees; provided that
         HRI may, if it so desires, be represented by counsel of its own
         selection, the fees for which counsel shall be paid by HRI. Any
         recovery from such action shall be retained by BIOGEN or shared by
         BIOGEN, its Affiliates or sublicensees.

                                       4

<PAGE>   5
          Confidential Materials omitted and filed separately with the
        Securities and Exchange Commission. Asterisks denote omissions.

     (b) In the event BIOGEN does not take action in a suit to enforce or defend
         any Licensed Patent Rights and HRI wishes to take action, HRI may take
         action and, at its option, join BIOGEN as a plaintiff. HRI shall
         exercise control over such action and shall bear all costs thereof,
         including, but not limited to attorney's fees; provided that BIOGEN
         may, if it so desires, be represented by counsel of its own selection,
         the fees for which counsel shall be paid by BIOGEN. Any recovery from
         such action shall be retained by HRI.

     6.3 In any suit as either party may institute or control to enforce or
defend the Licensed Patent Rights pursuant to this Agreement, the other party
hereto agrees, at the request and expense of the party initiating or controlling
the suit, to cooperate in all respects, to have its employees testify when
requested and to make available relevant records, papers, information, samples,
specimens, and the like.

     6.4 Neither party may enter into a settlement or consent judgment or other
voluntary and final disposition of any suit effecting the Licensed Patent Rights
without the consent of the other party, which consent shall not be unreasonably
withheld. Notwithstanding the foregoing, the party instituting or controlling
(as the case may be) any suit referred to in this Article 6 shall have the right
to settle any claims for infringement upon such terms and conditions as it, in
its sole discretion, shall determine (including through the granting of a
sublicense by BIOGEN).

     6.5 In the event an infringement or infringements by third parties of the
Licensed Patent Rights significantly affects BIOGEN's sales of Licensed
Product(s) by capturing [**] of BIOGEN's market share, and neither HRI nor
BIOGEN elect to bring an infringement suit against such infringer, the royalties
hereunder payable by BIOGEN pursuant to Article 2 shall be reduced by [**] of
the sums otherwise payable; provided, however, that BIOGEN presents information
to HRI showing the loss of market share and that such infringer has refused to
enter into a royalty bearing, sublicensing agreement with BIOGEN on terms
reasonably acceptable to BIOGEN.

     6.6 In the event that one or more patents, or particular claims therein
(which read on the Licensed Product) within the Licensed Patent Rights expire,
or are abandoned, or are declared invalid or by a court of last resort, or by
lower court from whose decree no appeal is taken, or certiorari is not granted
within the period allowed therefor, then such patents or particular claims
shall, as of the date of expiration or abandonment or final decree of invalidity
as the case may be, cease to be included within the License Patent Rights for
the purpose of this Agreement. HRI agrees to renegotiate in good faith with
BIOGEN a reasonable royalty rate under the remaining Licensed Patent Rights
which are unexpired and in effect, and under which BIOGEN desires to retain a
license if BIOGEN can demonstrate that subsequent to such expiration, invalidity
or abandonment of patents or particular claims (but not all of the Licensed
Patent Rights) BIOGEN's market share of Licensed Products has been reduced by
more than [**].

                                       5

<PAGE>   6

7.   DURATION AND TERMINATION
     ------------------------

     7.1 The license granted hereunder shall continue until expiration of the
last remaining patent granted from the Licensed Patent Rights, unless earlier
terminated in accordance with this Article.

     7.2 The royalty obligations in each country shall end on a
country-by-country basis upon expiration of the patent granted from the Licensed
Patent Rights in such country.

     7.3 BIOGEN shall have the right to terminate this Agreement upon ninety
(90) days prior written notice to HRI and upon payment of a termination fee
equal to the minimum annual royalty set forth in Section 3.2(a) of this
Agreement.

     7.4 HRI shall have the right to terminate this Agreement: (a) in the event
BIOGEN materially breaches this Agreement or fails to account for or pay
royalties or minimum royalties as herein provided, provided, however, that if
BIOGEN cures the said breach or default within ninety (90) days of notice, this
license shall continue in full force and effect; and (b) immediately upon
written notice to BIOGEN in the event of bankruptcy, liquidation or insolvency
of BIOGEN.

     7.5 Upon any termination of this Agreement nothing herein shall be
construed to release either party of any obligation matured prior to the
effective date of such termination, and BIOGEN may after the effective date of
such termination sell all Licensed Product(s) that it may have on hand at the
date of termination provided that it pays the royalties as provided in this
Agreement.

8.   NOTICES
     -------

     8.1 Any notice required or permitted to be given hereunder shall be sent in
writing by registered or certified airmail, postage prepaid, return receipt
requested, or by telecopier, air courier or hand delivery, addressed to the
party to whom it is to be given as follows:

If to BIOGEN:     BIOGEN, INC.
                  14 Cambridge Center
                  Cambridge, MA 02142
                  Telecopier:  617 491 1228
                  Attention:  Vice President -
                  Marketing and Business

With a copy to:   BIOGEN, INC.
                  14 Cambridge Center
                  Cambridge, MA 02142
                  Telecopier:  617 491 1228
                  Attention:  Vice President -
                  General Counsel

If to HRI:        HEALTH RESEARCH INC.
                  1683 Empire State Plaza
                  Albany, NY 12237

                                       6

<PAGE>   7

                  Telecopier:  (518) 474-4434
                  Attention:  Director of Operations

or to such other address or addresses as may from time to time be given in
writing by either party to the other pursuant to the terms hereof.

     8.2 Any notice sent pursuant to this Article shall be deemed delivered
within 5 days if sent by airmail and within 24 hours if sent by air courier or
hand delivery.

9.   ARBITRATION
     -----------

     9.1 The parties desire to avoid and settle without litigation future
disputes which may arise between them relative to this Agreement. Accordingly,
the parties agree to engage in good faith negotiations to resolve any such
disputes. In the event they are unable to resolve any such dispute through
negotiation, then such dispute shall be submitted to arbitration in accordance
with the Rules of the American Arbitration Association (hereinafter "Rules")
then in effect and the award rendered by the arbitrators shall be binding as
between the parties and judgment on such award may be entered in any court
having jurisdiction thereof, provided, however, that with respect to any matter
in dispute concerning royalties due and payable by one party, such party shall
have previously exercised its rights to have an auditor examine the records of
the other party pursuant to Article 3 herein before proceeding, and further
provided that a dispute relating to the payments set forth in Paragraphs 3.1 and
3.2 of this Agreement which arises out of a contention regarding the
interpretation or validity of the Licensed Patent Rights shall not be submitted
to arbitration.

     9.2 Three neutral arbitrators shall be appointed by the American
Arbitration Association in accordance with such Rules, and at least one of such
arbitrators shall be an attorney-at-law, and all decisions and awards shall be
made by majority of them except for decisions relating to discovery and
disclosures as set forth in Paragraph 9.3 hereof.

     9.3 Notice of a demand for arbitration of any dispute subject to
arbitration by one party shall be filed in writing with the other party and with
the American Arbitration Association. The parties agree that after any such
notice has been filed, they shall, before the hearing thereof, make discovery
and disclosure of all matters relevant to such dispute. Discovery and disclosure
shall be completed no later than ninety (90) days after filing of such notice of
arbitration unless extended upon a showing of good cause by either party to the
arbitration. The arbitrators may consider any material which is relevant to the
subject matter of such dispute even if such material might also be relevant to
an issue or issues not subject to arbitration hearing.

     9.4 In the event a patent which is the subject matter of an award rendered
by the arbitrators is subsequently determined to be invalid or unenforceable in
a judgment rendered by a court of competent jurisdiction from which no appeal
can or has been taken, such award may be modified by a court of competent
jurisdiction upon application by any party to the arbitration. Any such
modification shall govern the rights and obligations between the parties from
the date of such modification.

                                       7

<PAGE>   8

10.  MISCELLANEOUS PROVISIONS
     ------------------------

     10.1 Neither party shall assign this Agreement without the written consent
of the other party which consent shall not be unreasonably withheld; provided,
however, that either party, without such consent, may assign or sell the same to
an affiliate or in connection with the transfer or sale of all or substantially
all of its business or in the event of its merger, consolidation, or joint
venture with another company. Each assignee shall assume all obligations of its
assignor under this Agreement. No assignment shall relieve either party of
responsibility for the performance of any accrued obligations which such party
then has hereunder.

     10.2 This Agreement constitutes the entire understanding between the
parties and may not be varied except by a written document signed by both
parties.

     10.3 This Agreement shall be construed, governed, interpreted, and applied
in accordance with the laws of the Commonwealth of Massachusetts, except that
questions affecting the validity, construction, and effect of any foreign patent
shall be determined by the laws of the country in which the patents were
granted.

     10.4 The provisions of this Agreement are severable, and in the event that
any of the provisions of this Agreement are determined to be invalid or
unenforceable under any controlling body of law, such invalidity or
unenforceability shall not in any way affect the validity or enforceability of
the remaining provisions hereof.

     IN WITNESS WHEREOF, the parties hereto have hereunder set their hands and
seals and duly executed this License Agreement the day and year first written
above.

BIOGEN, INC.                               HEALTH RESEARCH INC.

By: /s/ Alan Tuck                          By: /s/ Lee J. VanDeCarr
   -----------------------------              -------------------------------

Name:  Alan Tuck                           Name:   Lee J. VanDeCarr

Title: Vice President-Marketing &          Title:  Sec/Treasurer
       Business

Date:  28 May 1990                         Date:   June 4, 1990

                                       8

<PAGE>   9

                                    EXHIBIT A
                                    ---------
LICENSED PATENT RIGHTS

1.  United States patent application Serial No. 395,482 filed August 18, 1989,
    entitled "Novel Inhibitors of Thrombin".

                                       9
<PAGE>   10

                      AMENDMENT NO. 1 TO LICENSE AGREEMENT

     This Amendment No. 1 to License Agreement is made as of this 1st day of
April, 1996 by and between Biogen, Inc., a Massachusetts corporation with its
principal offices located at 14 Cambridge Center, Cambridge, Massachusetts,
02142 ("Biogen") and Health Research, Inc., a not-for-profit corporation with
offices located at 66 Hackett Boulevard, Albany, New York 12209 ("HRI").

     Biogen and HRI are parties to a certain License Agreement dated as of June
4, 1990 ("License Agreement") under which HRI has granted to Biogen a license to
HRI's rights in certain jointly-owned patents. Biogen and HRI would like to
amend Section 10.1 of the License Agreement regarding assignment and
sublicensing. Therefore, they agree as follows:

     SECTION 1.  Section 10.1 of the License Agreement shall be amended to read
in its entirety as follows:

     10.1 Neither party shall assign this Agreement without the written consent
     of the other party, which consent shall not be unreasonably withheld;
     provided, however, that either party without such consent, may assign or
     sell the same to an affiliate or in connection with the transfer or sale of
     all or substantially all of its business or in the event of its merger,
     consolidation or joint venture with another company. Except as provided
     below, each assignee shall assume all obligations of its assignor.

     Each party shall give the other party prior written notice of any
     assignment for which consent is required hereunder. If a party providing
     notice of a proposed assignment has not received written objection to the
     assignment from the other party within ten (10) days after receipt of the
     notice, the other party shall be deemed to have consented to the assignment
     for purposes of this Section.

     Biogen is co-owner of the Licensed Patent Rights, and Biogen may decide to
     retain its rights and obligations under Sections 6.1 through 6.4 of this
     Agreement notwithstanding the assignment of its other rights and
     obligations to a third party. However, whether or not Biogen decides to
     retain such rights and obligations, Biogen's assignee, as a condition to
     such assignment, shall be obligated to pay (1) the applicable
     non-refundable fees set forth in Section 3.1 (if they have not previously
     been paid by Biogen), and (2) the royalties set forth in Section 3.2 of
     this Agreement.

     If, in connection with an assignment, Biogen is a sublicensee of its
     assignee, HRI shall be entitled to receive (i) royalties on its assignee's
     Net Sales pursuant to Sections 3.2(a) and (b), and (ii) pursuant to Section
     3.2(c), royalties on the Sublicense Income received by the assignee from
     sales by Biogen.

     Each party shall properly notify the other party in writing of any
     completed assignment. Except as expressly provided above, upon assumption
     by assignee of all or part of this Agreement in accordance with this
     Section 10.1, the obligations assumed by the assignee shall cease in their
     entirety to be obligations of the assignor, except that no assignment shall
     relieve either party of its responsibility to the other party for the
     performance of any obligations accrued prior to the date of the assignment.

<PAGE>   11

     SECTION 2. The reference in the sixth line of Section 6.5 of the License
Agreement to "Article 2" shall be changed to "Article 3."

     IN WITNESS WHEREOF, the parties have executed this Amendment as of the date
and year first above written.

BIOGEN, INC.                                HEALTH RESEARCH INC.

By: /s/ Kenneth M. Bate                     By: /s/ Lee J. VanDeCarr
   --------------------------------            -----------------------------

Name:  Kenneth M. Bate                      Name:  Lee J. VanDeCarr

Title:  VP Marketing & Sales                Title:  Sec/Treasurer

                                       2
<PAGE>   12

                             ASSIGNMENT OF LICENSE

     Agreement dated as of March 21, 1997 by and between BIOGEN, INC., a
corporation organized under the laws of the Commonwealth of Massachusetts with
its principal executive offices located at Fourteen Cambridge Center,
Cambridge, MA 02142 ("Biogen"), and THE MEDICINES COMPANY, a corporation
organized under the laws of the State of Delaware with its principal executive
offices located at Suite 408, One Cambridge Center, Cambridge, MA 02142 (the
"TMC").

     WHEREAS, Biogen has rights under a License Agreement dated as of June 6,
1990 by and between Biogen and Health Research, Inc., as amended by an
Amendment No. 1 to License Agreement dated as of April 1, 1996 (the "License");
and

     WHEREAS, TMC wishes to have assigned to it, and Biogen is willing to
assign to TMC, all of Biogen's rights and obligations under the License;

     NOW THEREFORE, for one dollar and other good and valuable consideration,
the receipt and sufficiency of which is hereby acknowledged, Biogen and TMC
hereby agree as follows:

1. TRANSFER OF LICENSE. Biogen assigns, transfers and conveys to TMC the
License and all of Biogen's rights and obligations under the License and TMC
accepts the same. TMC shall be responsible for, and shall pay or discharge,
any and all liabilities and obligations of Biogen under the License.

     IN WITNESS WHEREOF, Biogen and TMC have caused this Agreement to be
executed as a sealed instrument as of the date first written above.

BIOGEN, INC.                            THE MEDICINES COMPANY

By: /s/ James R. Tobin                  By: /s/ Clive A. Meanwell
   -------------------------------          ------------------------------
   James R. Tobin                           Clive A. Meanwell
   President and Chief Executive            President and Chief Executive
   Officer                                  Officer<PAGE>   1
          Confidential Materials omitted and filed separately with the
        Securities and Exchange Commission. Asterisks denote omissions.

                                                                    EXHIBIT 10.7

                                LICENSE AGREEMENT

     This LICENSE AGREEMENT is made and entered into this 21st day of March,
1997 by and between Biogen, Inc. ("Biogen"), a Massachusetts corporation, with
principal offices located at 14 Cambridge Center, Cambridge, Massachusetts
02142, and The Medicines Company, a Delaware corporation, with principal offices
located at One Cambridge Center, Cambridge, Massachusetts 02142 ("TMC").

                                  INTRODUCTION

     1.   Biogen is the owner of certain patents and other proprietary rights
related to HIRULOG(R) bivalirudin and related hirudin-based peptide analogs, and
has conducted clinical trials using HIRULOG(R) bivalirudin for the treatment of
percutaneous transluminal coronary angioplasty, acute myocardial infarction and
other diseases.

     2.   TMC is a biopharmaceutical company which is committed to the
development and commercialization of prescription pharmaceutical products.

     3.   TMC desires to obtain an exclusive right and license in and to
Biogen's technology, patent rights and proprietary know-how related to
HIRULOG(R) bivalirudin and other hirudin-based peptides to develop and
commercialize products based on such technology, patent rights and know-how
worldwide.

     4.   Biogen is willing to grant a license to TMC on the terms and
conditions set forth in this Agreement.

     NOW, THEREFORE, in consideration of the mutual promises and other good and
valuable consideration, the receipt and sufficiency of which are hereby
acknowledged, the parties agree as follows:

<PAGE>   2

     SECTION 1 - DEFINITIONS

     As used in this Agreement, the following terms, whether used in the
singular or plural, shall have the following meanings:

     1.1  "AFFILIATE", as applied to either party, shall mean any corporation,
partnership, joint venture or other legal entity which controls, is controlled
by or is under common control with such party. For purposes of this definition,
the term "control" shall mean (a) in the case of corporate entities, direct or
indirect ownership or control of at least fifty percent (50%) of the outstanding
equity entitled to vote for directors, and (b) in the case of non-corporate
entities, direct or indirect ownership of at least fifty percent (50%) of the
equity interest with the ability to otherwise control the management of the
entity.

     1.2  "AMI" shall mean acute myocardial infarction.

     1.3  "AMI TRIAL" shall have the meaning set forth in Section 4.2.

     1.4  "BIOGEN PATENT RIGHTS" shall mean all patents and patent applications
throughout the Territory, covering or relating to Biogen Technology, including
any substitutions, extensions, reissues, reexaminations, renewals,
continuations, continuations-in-part, divisionals and supplemental protection
certificates, which Biogen owns or Controls. Biogen Patent Rights existing as of
the Effective Date are set forth in APPENDIX A to this Agreement.

     1.5  "BIOGEN TECHNOLOGY" shall mean all Technology which Biogen owns or
Controls as of the Effective Date and which is reasonably useful in order to
research, develop, make, use, sell or seek approval to market Product.

     1.6  "CARDIOLOGY INDICATIONS" shall mean all therapeutic, prophylactic and
diagnostic applications in humans related to the management of coronary vessel
disease, including INTER ALIA, PTCA, AMI and unstable angina. Cardiology
Indications shall not include INTER ALIA,

                                      -2-

<PAGE>   3

arrhythmia, not of ischemic etiology, embolic or hemorraghic stroke or any
medical condition resulting from an abnormality of venous circulation.

     1.7  "COMMERCIAL DEVELOPMENT ACTIVITIES" shall mean pre and post
Product-launch clinical studies that are not required for regulatory approval of
Product in the Major Markets, pharmacoeconomic studies and sponsored educational
programs for health care professionals at which clinical and/or pharmacoeconomic
data related to Product are presented.

     1.8  "CONFIDENTIAL INFORMATION" shall mean all information and materials,
including without limitation, trade secrets and other proprietary information
and materials (whether or not patentable) regarding a Party's Technology,
products, business plans or objectives.

     1.9  "CONTROL" shall mean possession of the ability to grant a license or
sublicense, as provided herein, without violating the terms of any agreement or
other arrangement with any third party.

     1.10 "CSL" shall mean CSL Limited (formerly Commonwealth Serum Laboratories
Limited) or any successor in interest to the rights of CSL Limited under the CSL
Agreement.

     1.11 "CSL AGREEMENT" shall mean a certain License and Supply Agreement
between Biogen and CSL, dated as of September 30, 1991.

     1.12 "DISTRIBUTOR" shall mean a person or entity in a country who (i)
purchases Product or bulk Peptide from TMC or one of its Affiliates, and (ii)
assumes responsibility for a portion of the promotion, marketing, sales and
customer service effort related to Product in that country, and (iii) under an
implied or express sublicense, sells Product in that country. The term
Distributor shall not include a person or entity who provides a contract sales
force to serve, in whole or in part, as TMCs sales force with respect to sales
by TMC. For purposes of this Agreement, CSL shall be considered a Distributor of
TMC based on the current CSL Agreement,

                                      -3-

<PAGE>   4

and, to the extent that the CSL Agreement is modified, shall be considered a
Distributor if it meets the criteria set forth in this definition. Without
limiting the generality of the foregoing, Biogen acknowledges that TMC currently
intends to contract with Innovex for sales support, and agrees that Innovex
shall not be considered to constitute a Distributor by virtue of such sales
support.

     1.13 "EFFECTIVE DATE" shall mean the date of this Agreement.

     1.14 "EXISTING NON-CARDIOLOGY INDICATIONS" shall mean those indications,
set forth in Appendix E, that (a) are not Cardiology Indications and (b) as to
which Biogen had data from human clinical trials as of the Effective Date.

     1.15 "FDA" shall mean the United States Food and Drug Administration.

     1.16 "FTE" shall mean a full-time equivalent person year consisting of a
total of one thousand eight hundred eighty (1,880) hours per year of work
carried out by a Biogen employee.

     1.17 "FIELD" shall mean all therapeutic, prophylactic and diagnostic
applications in humans.

     1.18 "FIRST COMMERCIAL SALE" shall mean in each country of the Territory
with respect to each Product, (i) the first sale of the Product by TMC or any of
its Affiliates, Sublicensees or Distributors to a third party in such country in
connection with the nationwide introduction of the Product by TMC, its
Affiliates, Sublicensees or Distributors following marketing and/or pricing
approval by the appropriate governmental agency for the country in which the
sale is made, or (ii) when governmental approval is not required, the first sale
in such country in connection with the nationwide introduction of the Product in
that country.

     1.19 "HRI" shall mean Health Research, Inc. or any successor in interest to
the rights of Health Research Inc.'s under the HRI Agreement.

                                      -4-

<PAGE>   5

     1.20 "HRI AGREEMENT" shall mean a certain License Agreement between Biogen
and HRI, dated as of June 6, 1990, as amended.

     1.21 "IND" shall mean an Investigational New Drug application, as defined
under the United States Federal Food, Drug and Cosmetic Act, as amended.

     1.22 "MAA" shall mean an application for regulatory approval to sell
Product in the European Union and similar in purpose to an NDA in the United
States.

     1.23 "MAJOR MARKETS" shall mean the United States, the United Kingdom,
Germany, France, Italy, Spain and the Benelux region.

     1.24 "NDA" shall mean a New Drug Application or Product License Application
or equivalent filing filed for Product with the FDA.

     1.25 "NET SALES" shall mean the gross amount invoiced (not dependent on
whether such invoices have been actually paid) on sales of Product by TMC and
its Affiliates and Distributors to third parties, less the following items, as
determined from the books and records of TMC or its Affiliates or Distributors,
provided that such items do not exceed reasonable and customary amounts in the
country in which such sale or other disposition occurred: (i) freight, insurance
and other transportation charges, if billed separately; (ii) amounts repaid or
credited by reason of returns, rejections, defects, recalls or because of
retroactive price reductions; (iii) sales taxes, excise taxes, value-added taxes
and other taxes (other than income taxes) levied on the invoiced amount, (iv)
import and export duties; (v) cash, trade and quantity discounts actually given
or made; and (vi) rebates paid pursuant to government regulations. A sale of
Product by TMC to an Affiliate or Distributor for resale of the Product by such
Affiliate or Distributor shall not be considered a sale for the purpose of this
provision, but the resale of such Product by the Affiliate

                                      -5-

<PAGE>   6

or Distributor to a third party who is not an Affiliate or Distributor of TMC
shall be a sale for purposes of this Agreement.

     For purposes of this Agreement, "sale" shall mean any transfer or other
distribution or disposition, but shall not include transfers or other
distributions or dispositions of Product, at no charge, for pre-clinical,
clinical or regulatory purposes or to physicians or hospitals for promotional
purposes, provided such transfer, distribution or disposition is not made in
exchange for lower prices on other TMC products or for other noncash
consideration. In the event that consideration in addition to or in lieu of
money is received for the sale of Product in an arms-length transaction, the
fair market value of such consideration shall be included in the determination
of Net Sales for such sale. To the extent that Product is sold in other than an
arms-length transaction, Net Sales for such sale shall be the average sales
price of Product if sold in an arms-length transaction during the applicable
royalty reporting period in the country in which the non-arms-length transaction
occurred.

     In the event that Product is sold in the form of a combination Product
containing one or more active ingredients or components in addition to Product,
Net Sales for the combination Product shall be determined by multiplying actual
Net Sales of the combination Product (determined by reference to the definition
of Net Sales set forth above) during the royalty payment period by the fraction
A/A+B where A is the average sale price of Product when sold separately in
finished form and B is the average sale price of the other active ingredients or
components when sold separately in finished form in each case during the
applicable royalty reporting period in the country in which the sale of the
combination Product was made, or if sales of both the Product and the other
active ingredients or components did not occur in such period, then in the most
recent royalty reporting period in which sales of both occurred. In the

                                      -6-

<PAGE>   7
          Confidential Materials omitted and filed separately with the
        Securities and Exchange Commission. Asterisks denote omissions.

event that such average sale price cannot be determined for both Product and all
other active ingredients or components included in the combination Product, Net
Sales for purposes of determining payments under this Agreement shall be
calculated by multiplying the Net Sales of the combination Product by the
fraction C/C+D where C is the standard fully-absorbed cost of the Product
portion of the combination and D is the sum of the standard fully-absorbed costs
of all other active components or ingredients included in the combination
Product, in each case, as determined by TMC using its standard accounting
procedures consistently applied. In no event shall Net Sales of a combination
Product be reduced to less than [**] of actual Net Sales of such combination
Product (determined by reference to the definition of Net Sales set forth above)
by reason of any adjustment provision set forth in this paragraph.

     1.26 "NEW NON-CARDIOLOGY INDICATIONS" shall mean those indications that are
neither Existing Non-Cardiology Indications nor Cardiology Indications.

     1.27 "PEPTID" shall mean one or more of the hirudin-based peptide analogs
described in APPENDIX B to this Agreement.

     1.28 "PRODUCT" shall mean the finished form of a product that comprises,
contains or is Peptide and which or the manufacture, use or sale of which (i) is
covered by a Valid Claim of any Biogen Patent Rights in the country where such
Product is manufactured, used or sold and/or (ii) embodies any of the Biogen
Technology.

     1.29 "PTCA" shall mean percutaneous transluminal coronary angioplasty.

     1.30 "SEMILOG PROCESS" shall mean the joint biological /synthetic process
for producing Peptide.

     1.31 "SUBLICENSEE" shall mean any third party expressly licensed by TMC to
make, use and sell Product, but not including any Affiliate or Distributor of
TMC.

                                      -7-

<PAGE>   8

     1.32 "TECHNOLOGY" shall mean all information, data, concepts, formulas,
methods, procedures, designs, compositions, plans, applications, specifications,
techniques, processes, technical data, know-how, samples, biological materials,
inventions, discoveries and the like which a party owns (in whole or in part) or
Controls.

     1.33 "TECHNOLOGY TRANSFER" shall mean the transfer of Biogen Technology to
TMC, in accordance with Section 3.

     1.34 "TECHNOLOGY TRANSFER PLAN" shall have the meaning set forth in
Section 3.1

     1.35 "TERRITORY" shall mean all countries of the world.

     1.36 "TMC PATENT RIGHTS" shall mean all patents and patent applications
throughout the Territory, covering or relating to TMC Technology, including any
substitutions, extensions, reissues, reexaminations, renewals, continuations,
continuations-in-part, divisionals and supplemental protection certificates,
which TMC owns or Controls at any time.

     1.37 "TMC TECHNOLOGY" shall mean all Technology which TMC owns or Controls
as of the date of termination of this Agreement and which is reasonably useful
in order to discover, research, develop, make, use, sell or seek approval to
market Product.

     1.38 "UCB INFORMATION" shall mean information related to the manufacturing
of Peptide contained in the Chemistry, Manufacturing and Control (CMC) sections
of Biogen's existing INDs for Peptide, and stability data generated by UCB on
Peptide.

     1.39 "VALID CLAIM" shall mean (i) a claim of a pending patent application
which claim shall not have been canceled, withdrawn, abandoned or rejected by an
administrative agency from which no appeal can be taken or which shall not have
failed to issue as a patent within seven (7) years of the earliest claimed
priority date or (ii) a claim of an issued and unexpired patent which has not
lapsed or become abandoned or been declared invalid or unenforceable by a

                                      -8-

<PAGE>   9

court of competent jurisdiction or an administrative agency from which no appeal
can be or is taken.

     SECTION 2 - GRANT AND ASSIGNMENTS.

     2.1  LICENSE GRANT. Biogen hereby grants to TMC, and TMC hereby accepts
from Biogen, a royalty-bearing right and license under Biogen Technology and
Biogen Patent Rights to make, have made, import, use, offer to sell and sell
Product in the Territory in the Field. The license granted to TMC under this
Section 2.1 shall be exclusive subject only to the rights granted to CSL under
the CSL Agreement and any rights retained by HRI under the HRI Agreement.

     2.2  SUBLICENSE RIGHTS.

          (a)  TMC shall be entitled to extend the license granted to it under
Section 2.1 to any of its Affiliates and to grant sublicenses to its rights for
all indications in each country of the Territory other than the United States
and the countries of the European Union, provided that TMC shall obtain Biogen's
consent prior to granting any sublicense in Canada or Japan which such consent
Biogen agrees not to unreasonably withhold. TMC shall also be entitled to grant
sublicenses to the rights granted to it under Section 2.1 in the United States
and the countries of the European Union for New Non-Cardiology Indications,
provided that TMC shall obtain Biogen's consent prior to granting any such
sublicense which such consent Biogen agrees not to unreasonably withhold. All
Affiliates and Sublicensees, to whom TMC has extended or sublicensed its rights
under Section 2.1 shall agree to be bound by all of the applicable terms and
conditions of this Agreement. TMC shall advise Biogen of any extension of TMC's
rights to its Affiliates and shall provide copies to Biogen of each sublicense
promptly after such extension or sublicense becomes effective. TMC shall not
have the right to grant sublicenses to its rights

                                      -9-

<PAGE>   10

under Section 2.1 in the United States or any of the countries of the European
Union with respect to Cardiology Indications or Existing Non-Cardiology
Indications.

          (b)  TMC shall use commercially reasonable efforts to ensure that its
Affiliates and Sublicensees to whom TMC has extended or sublicensed its rights
under Section 2.1 shall comply with all applicable terms of this Agreement and
shall make all payments of compensation due and make all reports due under this
Agreement by reason of sales of Product by such Affiliates and/or Sublicensees.

          (c)  TMC shall use commercially reasonable efforts to ensure that all
Sublicensees to whom TMC grants rights to make, use and sell Product in New
Non-Cardiology Indications in the United States and the countries of the
European Union market Product solely for use in New Non-Cardiology Indications.

     2.3  ASSIGNMENT OF AGREEMENTS. Concurrently with execution of this
Agreement, the parties shall execute (i) an Assignment of License in the form
set forth in APPENDIX C hereto under which Biogen assigns to TMC, and TMC
accepts assignment of, all of Biogen's rights and obligations under the HRI
Agreement, and (ii) an Assignment of License and Supply Agreement in the form
set forth as APPENDIX D hereto under which Biogen assigns to TMC, and TMC
accepts assignment of, all of Biogen's rights and obligations under the CSL
Agreement.

     SECTION 3 - TECHNOLOGY TRANSFER AND SUPPLY OF MATERIAL

     3.1  TECHNOLOGY TRANSFER PLAN. As soon as reasonably practical after the
Effective Date, the parties shall meet to agree on a plan for Technology
Transfer (the "Technology Transfer Plan"). The Technology Transfer Plan shall
specify the Technology Transfer activities to be performed and the amount of
time to be devoted to such activities. The parties shall review and update the
Technology Transfer Plan, on a monthly basis, until the earlier to occur of (i)
completion of Technology Transfer or (ii) the end of the Technology Transfer
period, as set forth

                                      -10-

<PAGE>   11

in Section 3.2. Biogen shall not be required to devote time or perform
activities in connection with Technology Transfer beyond the time and activities
shown on the Technology Transfer Plan unless both parties agree on an update to
the Technology Transfer Plan.

     3.2  LIMITATION ON TECHNOLOGY TRANSFER. Notwithstanding anything in this
Agreement to the contrary, Biogen shall not be obligated to devote more than the
equivalent of 2.8 FTEs, in the aggregate, to Technology Transfer or, in the
event that Biogen has devoted an equivalent of 2.8 FTEs to Technology Transfer,
to perform Technology Transfer after the date which is four (4) months from the
Effective Date. The parties shall use their best efforts to complete Technology
Transfer within four (4) months from the Effective Date. If Biogen has devoted
an equivalent of 2.8 FTEs to Technology Transfer and Technology Transfer has not
been completed by the end of such four (4) month period, the parties may extend
the Technology Transfer period by mutual agreement.

     3.3  COSTS OF TECHNOLOGY TRANSFER. TMC shall pay Biogen's fully-burdened
costs associated with Technology Transfer, provided that the activities and the
time spent performing the activities for which the costs are to be paid are
reflected in the Technology Transfer Plan, as updated from time to time, or TMC
has specifically requested the additional time or activities. Biogen shall bill
TMC for Biogen's fully-burdened costs related to Technology Transfer on a
monthly basis. TMC shall pay all Biogen invoices within thirty (30) days of
receipt.

     3.4  ASSIGNMENT OF REGULATORY FILINGS AND OTHER PRODUCT-RELATED
INFORMATION.

     Biogen hereby assigns to TMC all of Biogen's right, title and interest in
(a) its existing INDs and equivalent regulatory filings in the Territory related
to Product and (b) subject to Section 5, any and all regulatory and clinical
information related to Product that Biogen owns or Controls as of the Effective
Date. Biogen and TMC shall jointly manage the transition of

                                      -11-
<PAGE>   12

Biogen's INDs or equivalent regulatory filings to TMC under this Section in such
a way as not to harm the existing relationship of either party with the relevant
regulatory authorities. Biogen may elect, or TMC may request, to have one or
more of Biogen's employees participate in meetings between TMC and regulatory
authorities regarding assignment of Biogen's INDs or equivalent regulatory
filings to TMC, PROVIDED that Biogen's right to elect to participate in any such
meeting shall terminate on December 31, 1997. TMC shall pay all of Biogen's
costs associated with the assignment of INDs or equivalent regulatory filings to
TMC, including the costs incurred by Biogen in sending Biogen representatives to
meetings with regulatory authorities at the request of TMC.

     3.5  SUPPLY OF MATERIAL.

          (a)  As soon as reasonably practical after the Effective Date but in
any event within ninety (90) days after the Effective Date, Biogen shall deliver
to TMC Biogen's existing inventory of Peptide as described in APPENDIX F (the
"Biogen Inventory"). In addition, Biogen shall, at TMC's request, provided such
request is made prior to September 18, 1997 (the "Completion Option Period"),
initiate completion of processing by UCB Bioproducts S.A. (collectively "UCB")
of approximately 30kg of Peptide intermediates (expressed in equivalent bulk
drug substance quantities) stored at UCB as of the Effective Date under the
terms of a Supply Agreement between Biogen and UCB, dated as of March 21,1997
(the "Supply Agreement") (a copy of which has been provided to TMC, and shall
deliver to TMC the resulting material (the "UCB Material"). TMC understands and
agrees that "processing", as the term is used in this Section, of the 30kg of
Peptide intermediates by UCB shall mean completion of the manufacturing of such
portion of the 30kg of Peptide intermediates as UCB, in consultation with Biogen
and TMC, determines is viable for further production (the "Unfinished Peptide")
using

                                      -12-

<PAGE>   13

the manufacturing process specified in Biogen's most recent IND for Peptide on
file with the FDA as of the Effective Date. In the event that UCB reports to
Biogen that any portion of the 30kg of Peptide intermediates is not viable,
Biogen shall use reasonable efforts to confirm UCB's determination. "Processing"
shall also include delivery by UCB with each batch of Peptide of a release
certificate and access for Biogen and/or TMC to review the relevant batch
records. "Processing" shall specifically not include (i) any analytical
process-related or other validation work, (ii) qualification of plant, equipment
or utilities, (iii) work towards a supplemental IND, NDA or any other regulatory
filing, (iv) any other work requested by regulatory authorities in connection
with a regulatory filing, (v) any work associated with filing or inspection of
the documentation or facilities by TMC or the regulatory authorities, or (vi)
any supporting activities including further development work (process-related
and analytical-related), stability standard or reference standard establishment
or requalification (collectively "Ancillary Services"). At or prior to
initiation of the completion of processing of the Unfinished Peptide under the
terms of this Agreement, TMC shall meet with UCB to negotiate the terms, if any,
under which UCB would be willing to provide, and TMC would be willing to accept,
Ancillary Services in connection with the Peptide manufactured by UCB. Biogen
represents that UCB is obligated to complete processing of the Unfinished
Peptide if the request is made during the Completion Option Period whether or
not TMC accepts Ancillary Services from UCB at the end of the negotiation
described in the preceding sentence. Upon delivery to Biogen by TMC during the
Completion Option Period of a request to have UCB complete processing of the
Unfinished Peptide, TMC, UCB and Biogen shall meet to agree upon a delivery
schedule for the resulting Peptide. Biogen represents that UCB has agreed to
deliver the Peptide resulting from processing of the Unfinished Peptide within
at least eighteen (18) months of receipt of the processing

                                      -13-

<PAGE>   14
          Confidential Materials omitted and filed separately with the
        Securities and Exchange Commission. Asterisks denote omissions.

request. Biogen shall use commercially reasonable efforts to enforce the Supply
Agreement after consultation with TMC.

          (b)  As part of Technology Transfer, Biogen shall provide to TMC
copies of quality control release test results existing as of the Effective Date
related to the Biogen inventory. Biogen shall perform additional HPLC tests on
the Biogen Inventory only at TMC's request and expense in accordance with the
Technology Transfer Plan.

          (c)  Biogen represents that Peptide delivered to TMC as part of the
Biogen Inventory was stored under the conditions set forth in APPENDIX F.

          (d)  TMC shall reimburse Biogen for the amount due to UCB for delivery
of the UCB Material, up to BEF [**]. TMC shall also reimburse Biogen for
any storage costs for the Biogen Inventory and the UCB Material incurred by
Biogen after the Effective Date. In addition, TMC shall reimburse Biogen for all
freight, storage, duties, taxes and insurance costs incurred in connection with
delivery of the Biogen Inventory and the UCB Material to TMC, including but not
limited to those costs incurred in shipping the Biogen Inventory to and from
Europe and storing the Biogen Inventory in Europe. All payments to be made by
TMC to Biogen under this paragraph shall be made within thirty (30) days of
receipt of each invoice therefor from Biogen.

     SECTION 4 - DUE DILIGENCE.

     4.1  INVESTMENT. TMC shall use commercially reasonable efforts to expend at
least $20 million (not including amounts spent on or as part of the AMI Trial)
in connection with pre-launch and post-launch commercialization activities
related to Product for the PTCA and AMI indications within [**] years of the
later of the date of approval of a NDA for Product in the PTCA indication and
the date of approval of a NDA for Product in the AMI indication.
Commercialization activities may include Commercial Development Activities.

                                      -14-

<PAGE>   15
          Confidential Materials omitted and filed separately with the
        Securities and Exchange Commission. Asterisks denote omissions.

     4.2  DILIGENCE. TMC shall use commercially reasonable efforts (defined, for
purposes of this Agreement, as those efforts consistent with the efforts that
would be exerted by a mid-size biopharmaceutical company in the development and
sale of its own products) to develop and commercialize Product in each of the
Major Markets. TMC shall develop Product for use in the treatment of PTCA and
AMI. Without limiting the generality of the foregoing, TMC shall use
commercially reasonable efforts to meet the following diligence milestones:

          (a)  Commence a phase III clinical trial of Product in the AMI
               indication (the "AMI Trial") by December 31,1998.

          (b)  File an NDA for Product in the PTCA indication by December 31,
               1998.

          (c)  File an NDA for Product in AMI indication by [**].

          (d)  File an MAA for Product in AMI indication by [**].

          (e)  Commence marketing and sales of Product in the United States in
               each indication (i) within six (6) months of receipt of a license
               from the FDA to market and sell Product in such indication, if no
               approvable letter is issued with respect to such indication or
               (ii) within four (4) months of receipt of the applicable FDA
               license, if an approvable letter is issued with respect to such
               indication.

     4.3  AMI TRIAL. TMC shall use a lead investigator for the AMI Trial who is
a nationally recognized expert in cardiology. TMC shall provide to Biogen a
draft of the protocol for the ANH Trial, and Biogen shall have the right to
review and comment on such protocol. The parties acknowledge and agree that the
phase III study design for the AMI Trial will be a mortality trial substantially
based on Biogen's phase II results with Peptide and streptokinase. TMC shall be
the sponsor of the AMI Trial for purposes of 21 C.F.R. section 312 et. seq. TMC

                                      -15-
<PAGE>   16

shall review the protocol for the AMI Trial with the FDA, and shall use
reasonable efforts to obtain the FDA's advice that the protocol is reasonable
for obtaining marketing approval of Product in the AMI indication.

     4.4  CONSEQUENCES OF FAILURE TO SATISFY DILIGENCE OBLIGATION

          (a)  If at any time Biogen believes that TMC has not satisfied its
diligence obligations under Section 4.1 and 4.2, then Biogen shall so notify
TMC. Within fifteen (15) days of the date of such notice, the parties shall meet
to discuss TMC's performance. If TMC is able to demonstrate to Biogen's
satisfaction that TMC used commercially reasonable efforts to meet its diligence
obligations, the parties shall negotiate in good faith to set new milestones
which are reasonable in light of any difficulties or any unforeseen events which
TMC may have encountered. If TMC is unable to demonstrate to Biogen's
satisfaction that TMC used commercially reasonable efforts to meet its diligence
obligations and if TMC does not agree with Biogen's assessment, the parties
shall enter into binding arbitration, under the terms of Section 14.7, within
ten (10) days of the meeting between the parties held under this Section,
PROVIDED, that the arbitrators selected by the parties pursuant to Section 14.7
to arbitrate any issue that arises under this Section 4.4(a) shall each be an
expert in the field of drug development in the United States.

          (b)  In the event that TMC agrees with Biogen's determination that TMC
failed to satisfy its diligence obligations under Section 4.1 or 4.2 or an
arbitration panel convened under paragraph (a) of this Section 4.4 determines
that TMC failed to satisfy its diligence obligations under Section 4.1 or 4.2,
Biogen shall have the right and option to terminate this Agreement for material
breach by TMC under Section 10.2.

                                      -16-

<PAGE>   17

     4.5  JAPAN DILIGENCE. In the event that TMC informs Biogen in writing that
it does not intend to develop, register, manufacture, market or sell, or
sublicense a third party to develop, register, manufacture or sell, Product in
Japan, and TMC's reasons for choosing not to enter Japan are not related to
potential parallel import or pricing issues or regulatory or patent obstacles
outside of TMC's control, Biogen shall have the right and option to (i)
terminate the license set forth in Section 2.1 as to Japan only on sixty (60)
days prior written notice to TMC and (ii) to exercise its rights under Section
10.5.

     4.6  TRANSDERMAL PRODUCT. No later than December 31, 1998, TMC shall submit
to Biogen a development plan for the transdermal application of Product (the
"Transdermal Plan"). The Transdermal Plan shall include commercially reasonable
milestones for development and commercialization of a transdermal Product. In
the event TMC does not use commercially reasonable efforts to meet the
milestones set forth in the Transdermal Plan, Biogen shall have the right to
terminate this Agreement as to the transdermal application of Product.

     4.7  STATUS REPORTS. Within forty-five (45) days of the end of each
calendar quarter, TMC shall provide to Biogen a written report describing in
reasonable detail the status of development and commercialization activities
related to Product, including the nature of the development and
commercialization activities undertaken by TMC and its Sublicensees and
Distributors, if any, during the preceding quarter, the results obtained and the
goals and plans for the next quarter. After Product launch, the status report
provided to Biogen under this Section shall include rolling four-quarter sales
forecasts for Product. TMC shall furnish to Biogen copies of final study reports
from clinical trials related to Product as soon as such reports are available.
At Biogen's request from time to time, TMC shall provide to Biogen verbal
updates on the status of development and commercialization efforts.

                                      -17-

<PAGE>   18

     SECTION 5 - CONFIDENTIALITY

     5.1  TREATMENT OF CONFIDENTIAL INFORMATION. Each party agrees that it shall
maintain the Confidential Information of the other party in strict confidence
and shall not disclose any such Confidential Information to a third party or use
such Confidential Information for any purpose other than as contemplated under
this Agreement. Each party agrees to exercise reasonable precautions to prevent
and restrain the unauthorized disclosure or use of the Confidential Information
of the other party by any of the receiving party's directors, officers, agents
or employees. TMC acknowledges and agrees that all regulatory and clinical
information assigned to TMC under Section 3.4 (b) shall, except as provided in
Section 5.2, continue to be Confidential Information of Biogen for purposes of
this Section 5.

     5.2  EXCEPTIONS.

          The provisions of Section 5.1 shall not apply to Confidential
Information which:

          (i)  was known to the receiving party prior to its disclosure by the
disclosing party;

          (ii) either before or after the date of disclosure to the receiving
party becomes generally known to the public by some means other than a breach of
this Agreement;

          (iii) is subsequently disclosed to the receiving party by a third
party having a lawful right to make such disclosure and who is not under an
obligation of confidentiality to the disclosing party;

          (iv) is independently developed by or for the receiving party without
reference to or reliance upon the Confidential Information received from the
disclosing party;

          (v)  is required by law, rule, regulation or bona fide legal process
to be disclosed, provided that the receiving party takes all reasonable steps to
restrict and maintain the confidentiality of such disclosure and provides
reasonable notice to the disclosing party; or

                                      -18-

<PAGE>   19

          (vi) is approved for release by the parties.

          The non-disclosure and non-use obligations under Section 5.1 shall
terminate as to any Confidential Information twelve (12) years after receipt of
such Confidential Information by the receiving party.

     5.3  PERMITTED DISCLOSURES. Notwithstanding anything to the contrary
contained in Section 5.1, TMC may disclose the Confidential Information of
Biogen licensed to TMC under Section 2.1 or assigned to TMC under Section 3.4,
other than the UCB Information, to third parties who (i) need to know the same
in order for TMC to secure regulatory approval for the sale of Product or (ii)
need to know the same in order to work towards the commercial development of
Product or to manufacture Product or (iii) need to know the same in order to
determine whether to enter into a sublicense agreement with TMC with respect to
the manufacture, use and/or sale of Product PROVIDED that such parties, other
than regulatory authorities, are bound by obligations of confidentiality and
non-use at least as stringent as those set forth in this Section 5. In addition,
TMC may disclose Confidential Information of Biogen (other than UCB Information
or any other Confidential Information of Biogen as to which Biogen would be
required to obtain the consent of a third party with respect to further
disclosure) to potential investors who have a need to know the same in order to
assess the status of their investment in TMC or to determine whether to invest
in TMC, provided that (i) the information to be disclosed is of a type
customarily disclosed to investors and (ii) the investors to whom the
information is disclosed are bound by obligations of confidentiality and non-use
with respect to such information at least as stringent as those set forth in
this Section 5.

     5.4  UCB INFORMATION. Notwithstanding anything herein to the contrary, TMC
shall not use the UCB Information for any purpose other than supporting the
regulatory filings for

                                      -19-

<PAGE>   20
            Confidential Materials omitted and filed separately with
      the Securities and Exchange Commission. Asterisks denote omissions.

Peptide assigned to TMC by Biogen under Section 3.4 ("Existing Regulatory
Filings"), and shall not disclose the UCB Information to any third party other
than regulatory authorities. TMC shall return to UCB all documents containing
UCB Information in TMC's possession in the event that maintaining UCB
Information is no longer required for purposes of supporting the Existing
Regulatory Filings, and shall take all reasonable steps to return promptly to
UCB any UCB Information in the possession of the FDA which might be returned to
TMC (except as otherwise required by the FDA) and to inform the FDA that
communication of such UCB Information to any third party requires UCB's express
written consent.

     SECTION 6 - PAYMENT OBLIGATIONS.

     6.1  LICENSE FEE. In consideration of the rights granted by Biogen, TMC
shall pay to Biogen a nonrefundable, noncreditable license fee of $2,000,000 on
the Effective Date.

     6.2  MILESTONE PAYMENTS. TMC shall make each of the following
nonrefundable, noncreditable payments to Biogen within thirty (30) days of the
first achievement of each of the following milestones:

              Event                                   Payment
              -----                                   -------

          (a) First Commercial Sale of Product        $[**]
              in the United States for treatment
              in AMI

          (b) First Commercial Sale of Product        $[**]
              in Europe for treatment in AMI

     6.3  ROYALTIES.

          (a)  TMC shall pay to Biogen earned royalties on Net Sales of Product
sold by TMC and/or its Affiliates and/or its Distributors at the following
rates:

                                      -20-

<PAGE>   21
            Confidential Materials omitted and filed separately with
      the Securities and Exchange Commission. Asterisks denote omissions.

       Annualized Net Sales                      Royalty Rate
       in a Calendar Year in Territory           On Net Sales of Product
       -------------------------------           -----------------------

       Less than or equal to $[**]               [**]

       Greater than $[**] but less               [**]
       than or equal to $[**]
       Greater than $[**] but less               [**]
       than or equal to $[**]
       Greater than $[**] but less               [**]
       than or equal to $[**]
       Greater than $[**]                        [**]

          (b)  Notwithstanding anything in this Agreement to the contrary, sales
by Sublicensees shall be included as TMC sales solely for purposes of
determining the royalty rate applicable to sales by TMC and/or its Affiliates
and/or its Distributors.

          (c)  The applicable royalty rate for a given calendar year shall be
based on the rate determined by reference to total Net Sales during the year,
and shall be applied retroactively to the first dollar of such Net Sales in such
calendar year. Adjustment payments shall be made as necessary in accordance with
Section 6.7.

          (d)  The obligation to pay royalties and a percentage of Sublicense
Royalty Income (as defined in Section 6.5) shall continue, on a
country-by-country basis, from the date of the First Commercial Sale of Product
in a country until the later of (i) twelve (12) years after the date of the
First Commercial Sale of such Product in such country or (ii) the date on which
the Product or its manufacture, use or sale is no longer covered by a Valid
Claim of any Biogen Patent Rights in such country.

                                      -21-

<PAGE>   22
            Confidential Materials omitted and filed separately with
      the Securities and Exchange Commission. Asterisks denote omissions.

     6.4  ROYALTY OFFSET.

          (a)  Subject to paragraph (d) of this Section 6.4, the royalty rates
set forth in Section 6.3 shall be reduced, on a country-by-country basis, by
[**]with respect to Net Sales of any Product in any calendar year if (i) neither
such Product nor its use or sale is covered during any part of such year by a
Valid Claim of a Biogen Patent Right in such country and (ii) third parties
selling Comparable Products, as defined below, have, in the aggregate, during
such year [**] or more of the volume-based market share in such country. For
purposes of this Section, "Comparable Product" shall mean a product which, if
sold on the Effective Date by a third party in the United States without a
license from Biogen, would infringe a Valid Claim of Biogen Patent Rights
related to Product existing as of the Effective Date.

          (b)  Subject to paragraph (c) and (d) of this Section 6.4, in the
event that TMC, in order to manufacture, use or sell Product in a country in the
Territory, reasonably determines that it must make a royalty payment to one or
more third parties (a "TMC Third Party Payment") to obtain a license or similar
right to manufacture, use or sell Product in such country, TMC may reduce the
royalty payment due Biogen under Section 6.3 on sales of Product, on a
country-by-country basis, by the amount of such TMC Third Party Payments paid on
such sales up to a [**] reduction in the applicable royalty rate set forth in
Section 6.3. The offset available under this paragraph (b) shall not apply to
royalty payments made or due under the HRI Agreement.

          (c)  Subject to paragraph (d) of this Section 6.4, with respect to any
sales as to which TMC is paying royalties at the [**] royalty rates under
Section 6.3, TMC may, in addition to other offsets available under paragraphs
(a) and (b) above, reduce the royalty payment due Biogen under Section 6.3 by
the amount of any payments made by TMC to HRI

                                      -22-

<PAGE>   23
            Confidential Materials omitted and filed separately with
      the Securities and Exchange Commission. Asterisks denote omissions.

under the HRI Agreement on such sales, but not more than the amounts that would
be payable to HRI at the rates in effect under the HRI Agreement on the
Effective Date.

          (d)  Until the later of (i) the date of receipt of marketing approval
for Product from the FDA for the AMI indication or (ii) the [**] anniversary of
the date of the First Commercial Sale of Product in any country in the PTCA
indication, TMC may offset against the royalty payment due to Biogen (A) any
costs incurred by TMC after the First Commercial Sale of Product for PTCA in
development or commercialization of Product for the AMI indication, provided
that the costs are incurred as part of [**] approved by Biogen, which approval
shall not be unreasonably withheld, and (B) any costs incurred by TMC in
connection with [**] which agreement shall not be unreasonably withheld, and
provided further that in no event (1) shall the amount offset under this
paragraph exceed [**] in the aggregate or (2) shall the amount of royalties
actually paid to Biogen under Section 6.3 for any royalty payment period be less
than [**] of Net Sales. Notwithstanding anything in this Agreement to the
contrary, TMC shall not be entitled to any offset under this paragraph (d) in
any calendar year in which Net Sales calculated in the manner set forth in
Section 6.3 are greater than [**]. TMC shall offset its costs under this
paragraph against royalties due for the calendar year in which the costs are
incurred and shall not carry over such costs to offset royalties for any other
calendar year. Notwithstanding anything herein to the contrary, TMC shall not be
entitled to apply the offsets available under any other paragraph of this
Section 6.4 (and shall not carry-over any such offsets) in any period in which
TMC is applying its offset for development costs as set forth in this paragraph
(d).

                                      -23-

<PAGE>   24
            Confidential Materials omitted and filed separately with
      the Securities and Exchange Commission. Asterisks denote omissions.

     6.5  SUBLICENSE ROYALTY INCOME. TMC shall pay to Biogen [**] of all royalty
income ("Sublicense Royalty Income") received by TMC from its Sublicensees with
respect to sales of Products.

     6.6  OFF-LABEL SALES BY SUBLICENSEES. In the event that Biogen can
reasonably demonstrate a loss in earned royalties from TMC as a result of
off-label sales by any of TMC's Sublicensees, TMC shall reimburse Biogen for
Biogen's loss of earned royalties up to the amount actually received by TMC from
such Sublicensee for such off-label sales.

     6.7  QUARTERLY PAYMENTS AND EFFORTS. Royalty payments and payments on
Sublicense Royalty Income shall be made quarterly (i) within ninety (90) days
following the end of the first calendar quarter of Product sales with respect to
Sublicense Royalty Income received and Net Sales on sales made during such
quarter, (ii) within sixty (60) days following the end of each of the second,
third and fourth calendar quarters of Product sales with respect to Sublicense
Royalty Income received and Net Sales on sales made during such quarter, and
(iii) within forty-five (45) days following the end of each calendar quarter
thereafter with respect to Sublicense Royalty Income received and Net Sales on
sales made during such quarter. Every payment shall be accompanied by a report
setting forth for the relevant quarter the following information:

          (a)  Net Sales by TMC and its Affiliates and Distributors, by country;

          (b)  Sales by Sublicensees by country (for purposes of calculating the
royalty rate);

          (c)  Quantity of Product sold, by country, by TMC, its Affiliates,
Distributors and Sublicensees;

          (d)  Sublicense Royalty Income received by TMC; and

                                      -24-

<PAGE>   25

          (e)  Total amount payable to Biogen.

          Since Net Sales in each calendar year to be used to finally determine
the applicable royalty rate for such year will not be known until the end of
such year, in order to make the quarterly payments specified under this Section
6.7, TMC shall use a royalty rate which is determined by annualizing the
year-to-date Net Sales. As changes in the royalty rate determined using
annualized Net Sales occur from one calendar quarter to the next calendar
quarter within the same calendar year, in addition to the payment for the
calendar quarter, TMC shall make the necessary adjustment in such calendar
quarter reflecting the change in the royalty rate applied to Net Sales in the
preceding calendar quarter or quarters. Within thirty (30) days of the end of
each calendar year, TMC shall calculate the actual royalty rate to which Biogen
is entitled based on the actual Net Sales for the year. In the event Biogen has
not received its full royalty amount for the year, TMC shall promptly make a
balancing payment to Biogen in the amount of the deficit. In the event TMC has
paid Biogen more than its full royalty amount for the year, Biogen shall
promptly reimburse TMC in the amount of the excess.

          6.8  FORM OF PAYMENT. All payments to be made under this Agreement
shall be made in United States dollars by check or wire transfer, at Biogen's
option.

          6.9  FOREIGN EXCHANGE. For purposes of computing Net Sales for Product
sold in currency other than United States Dollars, such currency shall be
converted into United States Dollars using the spot purchase rate published in
the Wall Street journal (New York Edition) for the last day of the calendar
quarter for which Net Sales are being calculated.

          6.10 TAXES. Any taxes required to be withheld by TMC under the laws of
any foreign country for the account of Biogen shall be promptly paid by TMC for
and on behalf of Biogen to the appropriate governmental authority, and TMC shall
furnish Biogen with proof of payment of

                                      -25-

<PAGE>   26

such tax within thirty (30) days following payment. Any such tax actually paid
on Biogen's behalf shall be deducted from royalty payments due Biogen. TMC
agrees to make all lawful and reasonable efforts to minimize such taxes to
Biogen.

          6.11 INTEREST ON PAYMENTS PAST DUE. Any amounts due under this
Agreement that are not paid when due shall bear interest at the lesser of (i) an
annualized rate of two percent over the prime rate then in effect at BankBoston,
or (ii) the highest rate permitted by applicable law.

          6.12 BOOKS AND RECORDS. For a period of three (3) years next following
each calendar year, TMC shall keep, and shall use commercially reasonable
efforts (which shall include obtaining and enforcing a contractual commitment)
to cause each of its Affiliates, Distributors and Sublicensees to keep, full,
true and accurate books and records containing all particulars relevant to its
sales of Products during such year in sufficient detail to enable Biogen to
verify the amounts payable to Biogen under this Agreement. Biogen shall have the
right, not more than once during any calendar year, to have the books and
records of TMC or any of its Distributors or Sublicensees related to the sales
of Products audited by a qualified nationally-recognized, independent accounting
firm of Biogen's choosing, during normal business hours upon reasonable notice,
for the sole purpose of verifying the accuracy of the amounts paid to Biogen
under this Agreement, PROVIDED, HOWEVER, that Sublicensees or Distributors who
refuse to submit to an audit on behalf of Biogen despite TMC's commercially
reasonable efforts (which shall include enforcing a contractual commitment) to
obtain their consent to such audit shall not be bound by the audit obligation
set forth in this sentence. In the event that an audit shows that TMC has
underpaid Biogen by five percent (5%) or more, then TMC shall pay for all costs
of such audit, otherwise the costs of such audit shall be borne by Biogen. In
all cases, TMC shall pay to Biogen any underpaid compensation promptly and with
interest at an annualized rate of

                                      -26-

<PAGE>   27

the prime rate then in effect at BankBoston, plus two percent (2%), and Biogen
shall promptly pay to TMC any overpaid compensation. All information and data
reviewed in any audit conducted under this Section shall be used only for the
purpose of verifying amounts due to Biogen under this Agreement and shall be
treated as Confidential Information of TMC subject to the terms of this
Agreement.

     SECTION 7 - PATENTS.

     7.1  PROSECUTION AND MAINTENANCE. During the term of this Agreement, TMC
shall have responsibility for prosecuting, maintaining and defending the Biogen
Patent Rights, and in doing so shall use a level of effort and professional
representation consistent with the level of effort and professional
representation a mid-size biotechnology company would use to prosecute, maintain
and defend its own patent rights. Notwithstanding anything herein to the
contrary, TMC shall obtain Biogen's written consent prior to (i) instituting any
reissue or reexamination proceedings with respect to any Biogen Patent Rights
that are issued patents as of the Effective Date, or (ii) making any strategic
decision in any opposition, nullity, reissue or reexamination proceedings
involving any Biogen Patent Rights that are issued patents as of the Effective
Date, which Biogen consent shall not be unreasonably withheld. TMC shall bear
all of the costs of prosecution, maintenance and defense of the Biogen Patent
Rights incurred after the Effective Date. TMC shall keep Biogen regularly
informed of the status of the Biogen Patent Rights. TMC shall provide copies to
Biogen of all filings and correspondence with the patent offices, administrative
boards or courts which TMC sends or receives in connection with prosecution,
maintenance and defense of the Biogen Patent Rights. As soon as practical after
the Effective Date, Biogen shall provide to TMC a copy of Biogen's existing
files on the Biogen Patent Rights. Biogen undertakes to promptly and fully
cooperate in, and to provide all information and data and sign any documents
reasonably necessary and requested by TMC for the prosecution,

                                      -27-

<PAGE>   28

maintenance and defense of the Biogen Patents Rights. If TMC decides to abandon
or to allow to lapse any Biogen Patent Right, TMC shall inform Biogen at least
ninety (90) days prior to the effective date of such decision and Biogen shall
be given the opportunity to prosecute such Biogen Patent Right which such Biogen
Patent Right shall no longer be subject to this Agreement. Upon termination of
TMC's responsibility for prosecuting and maintaining any Biogen Patent Rights,
TMC shall promptly deliver to Biogen all files related to the Biogen Patent
Rights, and shall take all action and execute all documents reasonably necessary
for Biogen to resume prosection.

     7.2  INFRINGEMENT.

          (a)  TMC and Biogen shall each promptly inform the other in writing of
any infringement of the Biogen Patent Rights of which such party has notice and
provide the other with any available evidence of infringement.

          (b)  In the event TMC, alone or with an Affiliate or Sublicensee,
wishes to take action in a suit to enforce any Biogen Patent Rights against
infringement, TMC may take action and, at its option and expense, join Biogen as
a plaintiff. In determining whether to bring an action to enforce any Biogen
Patent Rights, TMC shall act in a commercially reasonable manner, giving due
consideration to the threat represented by the infringement and the potential
risk to the Biogen Patent Rights involved. If within six (6) months after having
been notified by Biogen of any alleged infringement or providing notice to
Biogen of an alleged infringement, TMC has been unsuccessful in persuading the
alleged infringer to desist and has not brought, and/or is not diligently
prosecuting an infringement action, or if TMC notifies Biogen at any time prior
thereto of its intention not to bring suit against any alleged infringer, Biogen
may take action and, at its option, join TMC as a plaintiff in any suit.

                                      -28-

<PAGE>   29

          (c)  The party which institutes any suit to protect or enforce a
Biogen Patent Right shall have sole control of that suit and shall bear the
reasonable expenses of the other party, not including legal fees incurred by the
other party, in providing any assistance and cooperation as is requested
pursuant to this Section. The party initiating or carrying on such legal
proceedings shall keep the other party informed of the progress of such
proceedings and such other party shall be entitled to counsel in such
proceedings but at its own expense.

          (d)  Any award paid by third parties (whether by way of settlement or
otherwise) as the result of any proceedings initiated by TMC under this Section
7 shall first be applied to reimbursement of the unreimbursed legal fees and
expenses incurred by either party and then the remainder shall be divided
between the parties as follows:

          (i) If the amount is based on lost profits, (x) TMC shall receive an
          amount equal to the damages the court determines it has suffered as a
          result of the infringement, less the amount of any royalties (and/or
          payments on Sublicense Royalty Income) that would have been due to
          Biogen on sales of Product lost by TMC and/or its Affiliates,
          Distributors and Sublicensees as a result of the infringement had they
          made such sales; and (y) Biogen shall receive an amount equal to the
          royalties (and/or payments on Sublicense Royalty Income) that it would
          have received if such sales had been made by TMC and/or its
          Affiliates, Distributors and Sublicensees; and

          (ii) As to awards other than those based on lost profits, 3/4 to TMC
          and 1/4 to Biogen.

          (e)  Any award paid by third parties (whether by way of settlement or
otherwise) as the result of any proceedings initiated by Biogen under this
Section 7 shall first be

                                      -29-

<PAGE>   30

applied to reimbursement of the unreimbursed legal fees and expenses incurred by
either party and then shall be divided between the parties, 1/4 to TMC and 3/4
to Biogen.

     7.3  COOPERATION. In any suit as either party may institute or control to
enforce the Biogen Patent Rights pursuant to this Agreement, the other party
agrees, at the request and expense of the party initiating or controlling the
suit, to cooperate in all respects, to have its employees testify when requested
and to make available relevant records, papers, information, samples, specimens,
and the like.

     7.4  THIRD PARTY CLAIM. In the event that a third party at any time
provides written notice of a claim to, or brings an action, suit or proceeding
against a party or such party's Affiliates, Distributors or Sublicensees,
claiming infringement of its patent rights or unauthorized use or
misappropriation of its Technology based upon an assertion or claim arising out
of the development, manufacture, use or sale of Products, such party shall
promptly notify the other party of the claim or the commencement of such action,
suit or proceeding, enclosing a copy of the claim and/or all papers served.

     SECTION 8 - REPRESENTATIONS, WARRANTIES AND COVENANTS.

     8.1  CORPORATE ACTION. Each party represents and warrants to the other
party that: (i) it is free to enter into this Agreement; (ii) in so doing, it
will not violate any other agreement to which it is a party; and (iii) it has
taken all corporate action necessary to authorize the execution and delivery of
this Agreement and the performance of its obligations under this Agreement.

     8.2  COMPLIANCE WITH LAW. Each party covenants and agrees that in
conducting activities contemplated under this Agreement, it shall comply with
all applicable laws and regulations.. Without limiting the generality of the
foregoing, TMC covenants and agrees that in conducting activities in connection
with the manufacture, use or sale of Product, TMC shall comply with all
applicable laws and regulations.

                                      -30-

<PAGE>   31

     8.3  RIGHT TO LICENSE. Biogen represents and warrants to TMC that Biogen is
the owner or licensee of the Biogen Technology and Biogen Patent Rights and has
the right and ability to grant the licenses granted under this Agreement. In
addition, Biogen covenants and agrees that it will not enter into any agreement
or other arrangement with any third party following the Effective Date that
would limit TMC's right and ability to exploit the rights granted by Biogen to
TMC under this Agreement.

     8.4  DISCLAIMERS. THE REPRESENTATIONS AND WARRANTIES SET FORTH IN THIS
SECTION AND IN SECTION 3.5 ARE IN LIEU OF ALL OTHER REPRESENTATIONS AND
WARRANTIES NOT EXPRESSLY SET FORTH HEREIN. WITHOUT LIMITING THE GENERALITY OF
THE FOREGOING STATEMENT, BIOGEN DISCLAIMS ALL WARRANTIES, WHETHER EXPRESS OR
IMPLIED, WITH RESPECT TO BIOGEN TECHNOLOGY, BIOGEN PATENT RIGHTS, THE BIOGEN
INVENTORY AND THE UCB MATERIAL, INCLUDING, WITHOUT LIMITATION, ANY
REPRESENTATIONS OR WARRANTIES AS TO WHETHER PRODUCT CAN BE SUCCESSFULLY
DEVELOPED OR MARKETED, REGARDING THE ACCURACY, PERFORMANCE, UTILITY,
RELIABILITY, TECHNOLOGICAL OR COMMERCIAL VALUE, COMPREHENSIVENESS,
MERCHANTABILITY OR FITNESS FOR ANY PARTICULAR PURPOSE WHATSOEVER OF THE BIOGEN
TECHNOLOGY, BIOGEN PATENT RIGHTS, BIOGEN INVENTORY OR UCB MATERIAL OR AS TO THE
VALIDITY OF THE BIOGEN PATENT RIGHTS OR THAT THE MANUFACTURE, USE, MARKETING OR
SALE OF PRODUCTS BY TMC OR ANY OF ITS AFFILIATES, DISTRIBUTORS OR SUBLICENSEES
WILL NOT CONSTITUTE AN INFRINGEMENT OF THE INTELLECTUAL PROPERTY RIGHTS OF ANY
THIRD PARTY. NEITHER BIOGEN

                                      -31-

<PAGE>   32

NOR TMC SHALL BE LIABLE FOR SPECIAL, INDIRECT, INCIDENTAL OR CONSEQUENTIAL
DAMAGES ARISING OUT OF THIS AGREEMENT WHETHER BASED ON CONTRACT, TORT OR ANY
OTHER LEGAL THEORY.

     SECTION 9 - INDEMNIFICATION.

     9.1  INDEMNIFICATION BY TMC. TMC shall defend, indemnify and hold harmless
Biogen and its Affiliates and their respective employees, agents, officers,
shareholders and directors and each of them (the "Biogen Indemnified Parties")
from and against any and all liability, damage, loss, cost or expense of any
nature (including reasonable attorneys fees and expenses of litigation) incurred
or imposed upon the Biogen Indemnified Parties or any one of them in connection
with any claims, suits, actions, demands, proceedings, causes of action or
judgments resulting from or arising out of (i) the development, design, testing,
production, manufacture, sale, use or promotion of Product by TMC or any of its
Affiliates, Sublicensees, or Distributors or any of their respective agents or
employees; (ii) any other activities carried out by TMC or any of its
Affiliates, Sublicensees or Distributors or any of their respective agents or
employees, including any failure to comply in any material respect with
applicable laws or regulations, or (iii) breach by TMC of any term of this
Agreement, except to the extent any such claim results or arises from breach of
this Agreement by Biogen or the negligence or willful misconduct of Biogen or
any its Affiliates or any of their respective employees, agents, officers or
directors.

     9.2  INDEMNIFICATION BY BIOGEN. Biogen shall defend, indemnify and hold
harmless TMC and its Affiliates and their respective employees, agents,
officers, shareholders and directors and each of them (the "TMC Indemnified
Parties") from and against any and all liability, damage, loss, cost or expense
of any nature (including reasonable attorneys fees and expenses of litigation)
incurred or imposed upon the TMC Indemnified Parties or any one of

                                      -32-

<PAGE>   33

them in connection with any claims, suits, actions, demands, proceedings, causes
of action or judgments resulting from or arising out of the breach of this
Agreement by Biogen or the negligence or willful misconduct of Biogen or any its
Affiliates or any of their respective employees, agents, officers or directors.

     9.3  CONDITIONS TO INDEMNIFICATION. An indemnified party shall give prompt
notice to the indemnifying party (either TMC or Biogen, as the case may be) of
any claim for which the indemnified party may seek indemnification under Section
9.1 or 9.2 and, provided that the indemnifying party is not contesting the
indemnity obligation, shall permit the indemnifying party to control any
litigation relating to such claim and disposition of any such claim, provided
that the indemnifying party shall act reasonably and in good faith with respect
to all matters relating to the settlement or disposition of any claim as the
settlement or disposition relates to the indemnified party, and the indemnifying
party shall not settle or otherwise resolve any claim without prior notice to
the indemnified party. The indemnified party shall cooperate with the
indemnifying party in its defense of any claim for which indemnification is
sought under this Section.

     9.4  INSURANCE. At such time as Product is being marketed, TMC shall obtain
and shall thereafter maintain, at TMC's sole cost and expense, product liability
insurance for Product naming Biogen as an additional insured. The amount of the
insurance coverage obtained under this Section shall be at least $10 million,
combined single limit, for each single occurrence of bodily injury and/or
property damage and the like. TMC shall provide to Biogen copies of each
insurance policy obtained under this Section and all renewals of such policies.

     SECTION 10 - TERMINATION.

     10.1 TERM. Except as otherwise specifically provided herein and unless
sooner terminated pursuant to Sections 10.2 or 10.3, this Agreement and the
licenses and rights granted

                                      -33-

<PAGE>   34

hereunder shall remain in full force and effect until TMC's obligations to pay
compensation hereunder terminates in accordance with Sections 6.3 and 6.5. Upon
expiration of TMC's obligation to pay royalties and/or a percentage of
Sublicense Royalty Income under Sections 6.3 and 6.5 with respect to a specific
country as to which TMC's license is then in effect, the license shall be deemed
to be fully paid and TMC shall thereafter have a royalty-free right to use the
Biogen Patent Rights and Biogen Technology to make, have made, use, import,
offer to sell and sell Product in such country.

     10.2 TERMINATION FOR BREACH. In addition to any other available remedies,
either party shall have the right to terminate this Agreement in the event of a
material breach of this Agreement by the other party, provided that the breach
is not cured within ninety (90) days after written notice thereof is received
from the non-breaching party.

     10.3 TERMINATION FOR CONVENIENCE. TMC shall have the right to terminate
this Agreement for any reason upon ninety (90) days prior written notice to
Biogen.

     10.4 SURVIVAL OF RIGHTS AND OBLIGATIONS. Termination or expiration of the
Agreement for any reason shall be without prejudice to any rights which shall
have accrued to the benefit of either party prior to such termination or
expiration, including damages arising from any breach hereunder. In addition,
Sections 5, 6.12, 9, 10.6, 13, 14 and the last sentence of Section 7.1 shall
survive any such termination or expiration.

     10.5 CONSEQUENCE OF TERMINATION AS TO JAPAN. Upon termination under Section
4.5 of the rights and licenses granted to TMC in Japan but not the entire
Agreement, (i) TMC shall have no further right or license under this Agreement
in Japan, and (ii) TMC shall grant to Biogen and its Affiliates and sublicensees
a permanent and irrevocable right of access and reference to all regulatory
submissions, including regulatory approvals, applicable to Product in Japan, and
shall

                                      -34-

<PAGE>   35

notify the applicable regulatory authorities of such right no later than thirty
(30) days thereafter. If any right of access and reference granted under the
preceding sentence is not sufficient to permit Biogen or its sublicensees to
file an application for regulatory approval and receive regulatory approval for
the sale of Product in Japan, TMC shall within sixty (60) days of receipt of
notice from Biogen to that effect, provide Biogen with the complete data package
that TMC used in such regulatory submissions, or if none, in regulatory
submissions in United States in order to allow Biogen or its Affiliates or
sublicensees to conduct clinical trials or file for regulatory approval for the
sale of Product in Japan, provided that such data package shall be considered
Confidential Information of TMC and shall be subject to Section 5. At the time
of any termination of the license granted to TMC in Japan under Section 4.5, TMC
and Biogen shall negotiate in good faith a commercially reasonable royalty to be
paid to TMC for use of TMC-generated data and access to TMC's regulatory filings
related to Product.

     10.6 CONSEQUENCES OF TERMINATION OF AGREEMENT. If TMC terminates this
Agreement under Section 10.3 or if Biogen terminates this Agreement under
Section 10.2, TMC shall, at TMC's expense, return to Biogen all Biogen
Technology furnished to TMC by Biogen, including any unused Biogen Inventory and
UCB Material, and shall transfer to Biogen all TMC Technology generated in
connection with the Product development and commercialization program. In the
event Biogen terminates this Agreement under Section 10.2, TMC shall grant to
Biogen an exclusive, royalty-free license, with the right to grant sublicenses,
to all TMC Patent Rights and TMC Technology related to Product. If TMC
terminates this Agreement under Section 10.3, TMC shall grant to Biogen an
exclusive license, with the right to grant sublicenses, to TMC Technology and
TMC Patent Rights in consideration for which Biogen shall, as its sole
obligation to TMC, pay royalties to TMC on sales of Product (i) in indications
other than

                                      -35-

<PAGE>   36

Cardiology Indications if the manufacture, use or sale of the Product in such
indication is covered by a claim of a TMC Patent Right other than a claim to an
improvement to Peptide or the Semilog Process or (ii) in any indication if
marketing approval for Product in such indication was based on phase III
clinical data generated by TMC, at a royalty rate to be negotiated in good faith
by the parties at the time of termination based on the parties' relative levels
of investment in the Product and taking into consideration any damage or delay
to the development and commercialization of Product caused by TMC's termination
of this Agreement. Upon termination of this Agreement other than by TMC under
Section 10.2, TMC shall, at TMC's expense, grant to Biogen an irrevocable right
of reference or assign to Biogen, as requested by Biogen, TMC's rights in any
regulatory filings related to Product and shall assign to Biogen any trademarks,
together with all goodwill associated therewith, used in connection with
Product. Upon termination of this Agreement for any reason, TMC shall assign to
Biogen, at no cost to Biogen, (i) any regulatory filings and data and
information originally assigned by Biogen to TMC, (ii) all of TMC's rights in
the CSL Agreement and the HRI Agreement, and (iii) all of TMC's rights to the
HIRULOG trademark, together with all goodwill associated therewith, provided
that if this Agreement has been terminated by TMC under Section 10.2, Biogen
shall reimburse TMC for its out-of-pocket costs of assigning the trademark,
together with all goodwill associated therewith, and regulatory filings to
Biogen. Upon termination of this Agreement for any reason, the licenses granted
to TMC under Section 2.1 of this Agreement shall terminate and the parties shall
have no further rights or obligations under this Agreement except as set forth
in Section 10.4. Any matter related to termination with respect to which the
parties cannot agree will be referred to binding arbitration pursuant to Section
14.7. Notwithstanding anything in this

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<PAGE>   37

Section 10.6 to the contrary, neither party shall be prevented from initiating a
claim for damages due to a breach of this Agreement by the other party.

     SECTION 11 - NO HIRE.

     TMC shall not knowingly hire as an employee or employ directly as a
consultant any person who is an employee of Biogen at the time of the employment
offer from TMC or who has been an employee of Biogen within four (4) years of
the date of the employment offer from TMC. Breach of this Section 11 by TMC
shall be considered a material breach by TMC of this Agreement. In the event of
any breach by TMC of this Section 11, Biogen shall have the right to terminate
this Agreement for material breach under Section 10.2, or, in lieu of
terminating this Agreement, may elect the following remedy as payment of
liquidated damages: (i) immediate payment to Biogen by TMC of 20% and (ii) an
increase of $4,000,000 in the royalty rates applicable to Net Sales of Product
under Section 6.3 and the rate applicable to Sublicense Royalty Income under
Section 6.5 of this Agreement. Election of the liquidated damages remedy by
Biogen shall not be deemed a waiver and shall not in any way limit Biogen's
right to terminate this Agreement for any subsequent breach of this Section or
any material breach of any other provision of this Agreement.

     SECTION 12 - TRADEMARKS, PATENT MARKING AND LITERATURE.

     12.1 HIRULOG TRADEMARK.

          (a)  Biogen hereby assigns to TMC all of Biogen' s rights, title and
interest in and to the HIRULOG trademark in the Territory, together with all
goodwill associated therewith. Biogen shall execute all documents reasonably
requested by TMC to effect the foregoing assignment. TMC shall promptly
reimburse Biogen for all costs and expenses incurred by Biogen in connection
with assignment of the HIRULOG trademark, together with all goodwill associated
therewith, to TMC.

                                      -37-

<PAGE>   38

          (b)  TMC shall maintain and prosecute the HIRULOG trademark in the
Territory using efforts and professional representation consistent with the
level of effort and professional representation as would be applied by a
mid-size biopharmaceutical company in prosecuting and maintaining its own
trademarks. TMC shall bear all of the costs of prosecution and maintenance of
the HIRULOG trademark after the Effective Date. TMC shall provide copies to
Biogen of all filings of trademark applications and all notices of grants which
TMC sends or receives related to the HIRULOG trademark. If TMC decides to
abandon the HIRULOG trademark or allow the HIRULOG trademark to lapse in any
country, TMC shall inform Biogen at least ninety (90) days prior to the
effective date of such decision and, at Biogen's request, shall take all
reasonable action, at Biogen's expense, to assign the HIRULOG trademark,
together with all goodwill associated therewith, back to Biogen in such country.

     12.2 PATENT MARKING. At Biogen's request, TMC shall mark, and shall require
its Affiliates or Sublicensees to mark, any and all forms of Product and Product
packaging with an appropriate patent marking identifying the issued patents of
the Biogen Patent Rights which cover the Product.

     12.3 PROMOTIONAL LITERATURE. At Biogen's request, TMC shall describe its
relationship with Biogen in TMC's promotional literature and advertising related
to Product. Biogen shall have the right to review any such description prior to
use.

     SECTION 13 - PUBLICITY

     The parties agree that the public announcement of the execution of this
Agreement shall be in the form of a press release mutually agreeable to the
parties. Each party shall be entitled to make or publish any public statement
concerning this Agreement consistent with the press release or as otherwise
mutually agreed by the parties. The terms of this Agreement which are not
divulged in the approved press release may not be disclosed except to a
government agency

                                      -38-

<PAGE>   39

as required by law. In any disclosure made to a government agency under the
preceding sentence, the disclosing party shall request confidential treatment of
the sensitive terms and conditions such as financial terms of this Agreement,
and shall provide such confidential treatment request to the other party for
review and comment.

     SECTION 14 - GENERAL PROVISIONS.

     14.1 ASSIGNMENT. Neither party shall have the right to assign this
Agreement without the prior written consent of the other party, except that
either party without the consent of the other party may assign this Agreement to
an Affiliate or to a successor in interest or transferee of all or substantially
all of the assets of such party. This Agreement shall be binding upon and inure
to the benefit of the parties hereto and their respective successors in interest
and permitted assignees. Any such successor or permitted assignee of a party's
interest shall in writing expressly assume and agree to be bound by all of the
terms and conditions of this Agreement. No assignment shall relieve the assignor
of any of its obligations under this Agreement.

     14.2 FORCE MAJEURE. Neither party shall be liable to the other party for
any failure or delay in performance of any obligation under this Agreement if
the failure is caused by fire, explosion, flood, earthquake, strike or lockout,
embargo, civil commotions, riots, wars, or any similar cause beyond such party's
reasonable control, provided that the party claiming this exception has exerted
all reasonable efforts to avoid or remedy such event and provided such event
does not extend for more than six (6) months.

     14.3 INDEPENDENT PARTIES. The relationship between Biogen and TMC is that
of independent contractors. Biogen and TMC are not and shall not be deemed to be
joint venturers, partners, principal and agent, master and servant, employer or
employee, and have no relationship other than as independent contracting
parties. Neither party shall have the authority

                                      -39-

<PAGE>   40

to bind or obligate the other party in any manner except as may be expressly
provided herein or authorized in writing.

     14.4 ENTIRE AGREEMENT. This Agreement sets forth the entire agreement and
understanding between the parties as to the subject matter hereof and all prior
agreements negotiations, representations and understandings, including a certain
letter of intent dated February 7,1997, are superseded hereby. No amendments,
modifications or supplements to this Agreement may be made, except by means of a
written document which is signed by authorized representatives of both parties.

     14.5 SEVERABILITY. If any provision of this Agreement is found by a court
to be void, invalid or unenforceable, the same shall either be reformed to
comply with applicable law or stricken if not so conformable, so as not to
affect the validity or enforceability of this Agreement, except if the principal
intent of this Agreement is frustrated by such reformation or deletion in which
case this Agreement shall terminate.

     14.6 GOVERNING LAW. This Agreement shall be construed and enforced in
accordance with the laws of the Commonwealth of Massachusetts without reference
to its choice-of-law principles.

     14.7 DISPUTE RESOLUTION. Any dispute arising out of or relating to this
Agreement or to a breach thereof, including its interpretation, performance or
termination, may be submitted by a party for resolution by binding arbitration.
The arbitration shall be conducted by three (3) arbitrators. Each party shall
select one arbitrator to serve on an arbitration panel to decide the issue. The
arbitrator selected by a party shall not be a past or present employee of or
consultant to such party or of any Affiliate or Sublicensee of such party. The
arbitrators selected by the parties shall, within ten (10) days of their
selection, select a third member to serve on the panel.

                                      -40-

<PAGE>   41

If the arbitrators selected by the parties cannot, within ten (10) days of their
selection, agree on a third member, the parties shall request that the American
Arbitration Association ("AAA") select the third member who shall not be a past
or present employee of or consultant to either party or of any Affiliate or
Sublicensee of either party. Each party shall then have thirty (30) days from
the date the panel is complete to submit to the panel and to the other party a
written statement presenting such party's position on the issue. The panel
shall, within thirty (30) days after receipt of both parties statements, hold a
joint meeting on the issue at which each party will have an opportunity to make
a presentation and to respond to the other party's presentation. Within fifteen
(15) days of the conclusion of the meeting, the panel shall render its decision
in writing. The decision of the panel shall be final and binding on the parties.
Each party shall bear its own costs in connection with the arbitration
proceedings, including the costs of the arbitrator selected by it. The costs of
the third arbitrator will be shared equally. The arbitration shall be held in
the Commonwealth of Massachusetts and conducted under the rules of the AAA,
except as otherwise expressly provided in this Section.

     14.8 HEADINGS. The headings in this Agreement have been included for
convenience only, and shall not be used to construe the meaning of this
Agreement.

     14.9 WAIVER. Failure of a party to enforce its rights under this Agreement
shall not constitute a waiver of that right or the ability to later assert that
right relative to the particular situation involved or to terminate this
Agreement as a result of any subsequent default or breach.

     14.10 NOTICES. Any notices given pursuant to this Agreement shall be in
writing and shall be deemed delivered upon the earlier of (i) when received at
the address set forth below, or (ii) three (3) business days after mailed by
certified or registered mail postage prepaid and properly addressed, with return
receipt requested, (iii) one (1) business day after being sent by a

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<PAGE>   42

reputable nationwide overnight courier service, or (iv) when sent, if sent, by
facsimile, as confirmed by certified or registered mail or by overnight courier.
Notices shall be delivered to the respective parties as indicated:

         If to Biogen:

               Biogen, Inc.

               14 Cambridge Center
               Cambridge, MA 02142
               Telephone: (617) 679-2000
               Fax: (617) 679-2617

                          with a copy to Vice President - General Counsel

         if to TMC:
               The Medicines Company
               One Cambridge Center
               Cambridge, MA 02142
               Telephone: (617) 225-9099
               Fax: (617) 225-2397

                          with a copy to President

     14.11 COUNTERPARTS. This Agreement may be executed in any number of
separate counterparts, each of which shall be deemed to be an original, but
which together shall constitute one and the same instrument.

     IN WITNESS, WHEREOF, the parties have executed this Agreement as of the
date set forth above.

BIOGEN, INC.                              THE MEDICINES COMPANY

By: /s/ James R. Tobin                    By: /s/ Clive A. Meanwell
    -----------------------------             -------------------------------
    James R. Tobin                            Clive A. Meanwell
    President and                             President and
    Chief Executive Officer                   Chief Executive Officer

                                      -42-

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