Document:

EX-10.58

 Exhibit 10.58 

Dated the 4th day of November 2014 
  

JOHN RONAN AND CASTLE COVE PROPERTY DEVELOPMENTS LIMITED 
  

Landlord 
 HORIZON PHARMA SERVICES LIMITED 

 
 Tenant 

HORIZON PHARMA PUBLIC LIMITED COMPANY 
 Guarantor

  
 LEASE 

 
 Part First Floor (Rear), Connaught House, 1 Burlington Road, Dublin 4 

 
 EVERSHEDS 

Solicitors 
 One Earlsfort Centre 

Earlsfort Terrace 
 Dublin 2 

 CONTENTS 
  

 

							
	 1
		 DEFINITIONS:
		 	1	  
			
	 2
		 INTERPRETATION
		 	8	  
			
	 3
		 DEMISE
		 	9	  
			
	 4
		 TENANT’S COVENANTS
		 	9	  
			
	 5
		 LANDLORD’S COVENANTS
		 	25	  
			
	 6
		 PROVISOS
		 	27	  
			
	 7
		 TENANT’S BREAK OPTION
		 	31	  
		
	 SCHEDULE 1
		 	33	  
		
	 SCHEDULE 2
		 	38	  
		
	 SCHEDULE 3
		 	45	  
		
	 SCHEDULE 4
		 	48	  
		
	 SCHEDULE 5
		 	49	  
		
	 SCHEDULE 6
		 	52	  

 THIS LEASE made the 4th day of November 2014 

BETWEEN 
  

	(1)	 JOHN RONAN of Dargle Cottage, Dargle, Enniskerry, Co Wicklow AND CASTLE COVE PROPERTY DEVELOPMENTS LIMITED (registration number 406988) having
its registered office at c/o Cooney Carey, The Courtyard, Units 15-16 Carmanhall Road, Sandyford, Dublin 18 (the “Landlord” which expression where the context so admits shall include their respective successors in title,
administrators and assigns); 

  

	(2)	 HORIZON PHARMA SERVICES LIMITED (registration number 412938) a limited liability company having its registered office at 25/28 North Wall
Quay Dublin 1 (the “Tenant” which expression shall where the contract so admits or requires include its successors in title, administrators and permitted assigns); and 

 

	(3)	 HORIZON PHARMA PUBLIC LIMITED COMPANY (registration number 507678) a public limited company having its registered office at 25/28 North Wall
Quay Dublin 1 (the “Guarantor” which expression shall where the contract so admits or requires include its successors in title, administrators and permitted assigns) 

OPERATIVE PROVISIONS 
  

	1	 DEFINITIONS: 

In this Lease the following expressions shall have the following meanings: 

 

									
	 “Arbitration Act”,
		 means the Arbitration Act 2010

		
	 “Basement”
		 means the basement of the Building shown on Plans 1 and 2 annexed to this Lease

		
	 “Base Rate”
		 the annual rate of interest for the time being chargeable under Section 22 of the Courts Act 1981 or if there is no such rate the nearest corresponding
rate

		
	 “BER Certificate”
  

“Block A”
		 A BER certificate as defined by the EPB Regulations

 
 means the building shown on Plan 3 annexed to this Lease and thereon
outlined in blue

		
	 “Break Option Date”
		 the date which is the tenth (10th) anniversary of the Term Commencement Date.

		
	 “Building”
		 means the Building described in Part II of the Schedule 1

		
	 “Building Regulations”
		 the Building Regulations 1997 to 2013, the Building Control Regulations 1997 to 2014 and any Code of Practice for Inspecting and Certifying Buildings and
Works published from time to time in exercise of the powers conferred by the Building Control Acts 1990 to 2014

  
 1 

									
	 “Business Hours”
		 means the hours of 0700 hrs to 1900 hrs inclusive Monday to Friday excluding bank holidays, or such other business hours as the Landlord (or its agent) acting
reasonably may notify to the Tenant in writing (which includes communication by email) from time to time throughout the Term

		
	 “Capital Good”
		 has the meaning attributed to that term under Section 2 and Section 62(2) of the VAT Act

		
	 “Capital Goods Record”
		 has the meaning attributed to that term under Section 64(12) of the VAT Act

		
	 “Car Spaces”
		 means the six (6) car parking spaces more particularly described in paragraph 2 Part IV of Schedule 1

		
	 “Common Areas”
		 means all such areas of the Building as are not for the time being let separately or designed or intended to be let separately and the other facilities which
are designed or provided from time to time by the Landlord for common or general use or benefit to the tenants in the Building including without prejudice to the generality of the foregoing the main structure of the Building, the Basement, car park
ramp, service yards, roof, foundations, external walls, internal load bearing walls and structural parts of the roof, ceilings and floors, all party structures, office accommodation reserved in the Building for staff employed for the management of
the Building, any parts of the Building reserved by the Landlord for the housing of plant, machinery and equipment, bathroom facilities which are not included in any lease of part of the Building, Conduits (except those exclusively serving any
Lettable Area) entrance halls, the Gym, the Reception, corridors, passages, lobbies, landings, staircases, the lifts made available for use by the occupiers of the Building and other amenities which are from time to time designated by the Landlord
for the common use of the tenants in the Building

		
	 “Conduits”
		 mean all sewers, drains, pipes, gullies, gutters, ducts, mains, watercourses, channels, subways, wires, cables, conduits, flues and other conducting media of
whatsoever nature and kind

		
	 “Connected”
		 has the meaning set out in Section 97(3) of the VAT Act

  
 2 

									
	 “Deed of Renunciation”
		 means a valid and effective renunciation of any statutory tenancy renewal rights including any under the provisions of Section 4 of the Landlord and Tenant
(Amendment) Act 1994 as amended by Section 47 of the Civil Law (Miscellaneous Provisions) Act 2008

		
	 “Easements Rights and Privileges”
		 means those specified in Part IV of the Schedule 1

		
	 “Enactment”
		 means every Act of Parliament and the Oireachtas and Law of the European Community now or hereafter to be passed and every instrument directive regulation
and bye-law made thereunder which has force in Ireland

		
	 “EPB Regulations”
		 the European Union (Energy Performance of Buildings) Regulations 2012

		
	 EURIBOR”
		 “means:

			
			(a)		 the percentage rate per annum determined by the Banking Federation of the European Union for the relevant interest period, displayed on the appropriate
page of the Telerate screen. If the agreed page is replaced or service ceases to be available, the Landlord may specify another page or service displaying the appropriate rate; or

			
			 (b)
		 (if no such rate is available for the relevant period) the arithmetic mean of the rates (rounded up to five decimal places) as supplied to the Landlord at
its request, quoted by the reference banks to leading banks in the European interbank market,

		
			 as of 11:00 a.m. (Brussels time) on the day which is two TARGET Days (ie. days on which the Trans-European Automated Real-time Gross Settlement Express
Transfer payment system is open for the settlement of payments in euro) before the first day of the relevant interest period unless market practice differs in the European interbank market, in which case on the day determined by the Landlord in
accordance with market practice in the European interbank market (and if quotations would normally be given by leading banks in the European interbank market on more than one day, the Quotation Day will be the last of those days)

  
 3 

									
	 “Exceptions and Reservations”
		 means those specified in Part III of Schedule 1

		
	 “First Floor Common Areas”
		 Means any Common Areas on the first floor of the Building.

		
	 “First Floor Lettable Areas”
		 means all such areas of the first floor of the Building as are for the time being let separately or designed or intended to be let separately and excluding,
for the avoidance of doubt, all Common Areas

		
	 “First Service Charge”
		 means all costs and expenses which are at any time hereafter during the Term properly expended, incurred or payable by the Landlord or to be expended,
incurred or paid in providing all or any of the services set out in Part II of Schedule 2 and discharging the costs specified in Part III of Schedule 2

		
	 “Gale Days”
		 means 1st January, 1st April, 1st July and 1st October in every year

		
	 “Guarantor”
		 means the person(s) if any named as “Guarantor” at the commencement of this Lease and any person(s) who during the Term covenant(s) with the
Landlord in the terms set out in Schedule 5 and references to “Guarantor” include where the context so admits or requires the personal representatives, successors and assigns of any such person(s)

		
	 “Group Company”
		 means any company which is a subsidiary or holding company of the Tenant and/or within the same group of companies as the Tenant within the meaning of Section
155 of the Companies Act, 1963

		
	 “Gym”
		 means the gym located at Level Basement –1 of the Building comprising 1,216 square feet and shown hatched green on Plan 1 annexed to this
Lease

		
	 “Gym Rent”
		 means the rent attributable to the Gym calculated at a rate of €25.00 (twenty five euro) per square foot
until the 1 August 2015 and, from that date and from each fifth anniversary thereof, at a rate per square foot determined in accordance with Schedule 2, Part I, paragraph 11 on each such review date.

		
	 “Insurance Rent”
		 means in respect of any period for which the same is required to be calculated the Tenant’s Proportion of the aggregate of the following
costs:

				
					a)		 The cost properly incurred in insuring the Building against the Insured Risks for the relevant period for the full reinstatement cost of the Building
including but not limited to the cost of the following:

					
							(i)		 architects, engineers and quantity surveyors and other professional fees and incidental expenses properly incurred (including VAT thereon);

  
 4 

									
							(ii)		 the costs of shoring up, hoarding, demolishing, site clearing and similar expenses;

					
							 (iii)
		 any fees or charges on the submission of an application for planning permission and compliance with Building Regulations and any costs which might be properly incurred in
complying with any other Enactment in carrying out all demolition, reinstatement and repair work;

					
							 (iv)
		 fire brigade and other emergency services;

					
							(v)		 a reasonable provision for inflation; and

					
							 (vi)
		 all stamp duty and other taxes or duties exigible on any contract or agreement as may be entered into relative to the demolition, reinstatement and repair
work;

				
					(b)		 The reasonable and proper cost of employing the Landlord’s Surveyor to determine the reinstatement value of the Building as often as is reasonably
necessary but not more than once in any twelve month period.

				
					(c)		 Any amount which the Landlord may expend in maintaining and effecting insurance in respect of not less than four years loss of rent and First Service Charge
and Second Service Charge having regard to potential increases or decreases of rent in accordance with Clause 3 and with any addition to the sum insured as the Landlord may decide in respect of VAT.

				
					(d)		 Any cost of effecting and maintaining insurance covering the public liability, property owners liability and employers liability in relation to the Premises
and anything done therein and insurance in respect of fire brigade charges.

  
 5 

									
					(e)		 (Without prejudice to all other provisions in this Lease relating to the vitiation of any policy of insurance) any amount which the Landlord may expend in
paying all additional premiums and any other amounts on any policy or policies of insurance as a result of anything done or omitted by the Tenant.

				
					(f)		 Any amount equivalent to the total of all excess sums which the insurers are not liable to pay out on any insurance claim in respect of any of the policies of
insurance mentioned in this definition and which the Landlord has expended in replacing the damaged or destroyed parts of the Premises.

				
					(g)		 Any professional fees relating to insurance including fees for insurance valuations carried out at reasonable intervals and all fees and expenses payable to
advisers in connection with effecting and maintaining insurance policies and handling claims required from time to time throughout the Term for reasons of good estate management.

				
					(h)		 Any amount which the Landlord may expend in effecting and maintaining any other policy or policies of insurance which the Landlord may acting reasonably deem
necessary in the interests of good estate management

		
	 “Insured Risks”
		 means loss, damage or destruction whether total or partial caused by fire, explosion, lightning, impact, earthquake, aircraft and articles dropped therefrom,
flood, storms and tempest, terrorism, riot and civil commotion and malicious damage or bursting or overflowing of water tanks, apparatus and pipes, subsidence and such other risks as the Landlord may from time to time in its reasonable discretion
consider prudent or desirable to insure subject to such exclusions and limitations as are from time to time imposed by the insurers

		
	 “Landlord’s Specification”
		 means the specification detailed in the document attached at Schedule 4

		
	 “Lettable Areas”
		 means all such areas of the Building as are for the time being let separately or designed or intended to be let separately and excluding, for the avoidance of
doubt, all Common Areas

		
	 “this Lease”
		 means this Lease and any document which is made supplemental to it

  
 6 

			
	 “Nearby Property”
		 any land premises or building which adjoins neighbours or is in the vicinity of the Premises including (if applicable) any building or development of which the Premises
is part

		
	 “Permitted Use”
		 means use as offices with associated parking

		
	 “Planning Acts”
		 means the Planning and Development Acts, 2000 to 2014

		
	 “Plans”
		 means the plans attached hereto

		
	 “Premises”
		 means the premises described in Part I of Schedule 1

		
	 “Prescribed Rate”
		 the rate per cent per day for the time being chargeable under section 1080 of the Taxes Consolidation Act 1997 (or such other periodic rate of interest as may from time
to time be chargeable upon arrears of tax) or if the Landlord shall so elect the rate of 10% per annum

		
	 “Quotation Day”
		 means in relation to any period the day on which quotations for deposits in euro for delivery on the first day of such period would ordinarily be given provided that if
for any period quotations would ordinarily be given on more than one date the Quotation Date shall be the last of those days

		
	 “Reception”
		 means the main reception area comprising 2,195 (two thousand one hundred and ninety five) square feet on the upper ground floor of the Building shown shaded pink on Plan
4 annexed to this Lease and forming part of the Common Areas

		
	 “Reception Rent”
		 means the rent attributable to the Reception calculated at a rate of €50.00 (fifty euro) per square foot until 1
August 2015 and, from that date and from every fifth anniversary thereof, at a rate per square foot determined in accordance with the Schedule 2, Part I, paragraph 11 on each such review date.

		
	 “Rent Commencement Date”
		 means          day of
                     2014

		
	 “Safety File”
		 means the file to be maintained pursuant to the Safety Health and Welfare at Work (Construction) Regulations 2006 to 2013

		
	 “Second Service Charge”
		 Means all costs and expenses which are at any time during the Term properly expended, incurred or payable by the Landlord or to be expended, incurred or paid in providing
all or any of the services set out in Part II of Schedule 6 and discharging the costs specified in Part III of Schedule 6.

  
 7 

			
	 “Tenant’s Proportion”
		 means the proportion which the net lettable floor area of the Premises (which is agreed as being 10,266 square feet (ten thousand two hundred and sixty six square feet))
bears to the net lettable floor area of all lettable areas of the Building and calculated in accordance with the Measurement Practice and Guidance Notes issued by the Irish Auctioneers and Valuers Institute and the Society of Chartered Surveyors in
the Republic of Ireland

		
	 “Tenant’s Share”
		 means the proportion which the net lettable floor area of the Premises (which is agreed as being 10,266 square feet (ten thousand two hundred and sixty six square feet))
bears to the net lettable floor area of all First Floor Lettable Areas and calculated in accordance with the Measurement Practice and Guidance Notes issued by the Irish Auctioneers and Valuers Institute and the Society of Chartered Surveyors in the
Republic of Ireland

		
	 “Term”
		 means the term of fifteen (15) years commencing on (and including) the Term Commencement Date and expiring on the
             day of 

		
	 “Term Commencement Date”
		 means          day of
                     2014

		
	 “Utilities”
		 means water, drainage, gas, electricity, soils and waste of all kinds, telephone and other communication systems, and any other services

		
	 “VAT”
		 means Value Added Tax or any tax of a similar nature that may be substituted for it

		
	 “VAT Act”
		 means the Value Added Tax Consolidation Act 2010 as amended, re-enacted or extended from time to time

  

	2	 INTERPRETATION 

In this Lease: 
  

	 	(a)	 Unless the context otherwise requires words importing the singular include the plural and vice versa and words importing one gender include both other
genders; any references to a schedule is to a schedule to this Lease; and references to clauses or sub-clauses are to clauses or sub-clauses of this Lease. 

  

	 	(b)	 References to a month or months are to a calendar month or months. 

 

	 	(c)	 Where a party comprises more than one person covenants and obligations of that party take effect as joint and several covenants and obligations.

  
 8 

	 	(d)	 Any right of (or covenant to permit) the Landlord to enter on the Premises shall also be construed as entitling the Landlord to remain on the Premises with
or without equipment and permitting such right to be exercised by all persons properly authorised by the Landlord. 

  

	 	(e)	 The last year of the Term includes the final year of the Term if it shall determine otherwise then by effluxion of time and references to the expiry of the
Term include such other determination. 

  

	 	(f)	 Reference to any statute or statutes (whether specifically named or not) or to any sections or sub-sections therein shall include any amendments or
re-enactments thereof from time to time in force and all statutory instruments, orders, notices, regulations, directions, bye-laws, permissions and plans from time to time made issued or given thereunder or deriving validity therefrom.

  

	 	(g)	 The titles or headings appearing in this Lease are for reference only and shall not affect its construction or interpretation. 

 

	3	 DEMISE 

 In
consideration of the rents reserved by this Lease and of the covenants on the part of the Tenant contained in this Lease the Landlord demises unto the Tenant ALL THAT the Premises together with the Easements Rights and Privileges but
excepting and reserving unto the Landlord the Exceptions and Reservations TO HOLD the Premises unto the Tenant for the Term YIELDING AND PAYING therefor during the Term: 

 

	3.1	 FIRSTLY the initial yearly rent of €482,970.00 (four hundred and eighty two thousand, nine
hundred and seventy euro) per annum being €461,970.00 (four hundred and sixty one thousand nine hundred and seventy euro) per annum in respect of the office premises and €21,000.00 (twenty one thousand euro) per annum in respect of the Car Spaces (subject to review in accordance with Schedule 3) to be paid as and from the Rent Commencement Date by four equal quarterly
payments in advance on the Gale Days the first payment to be made on the date of this Lease; 

  

	3.2	 SECONDLY by way of additional rent the Tenant’s Proportion of the First Service Charge payable at the times and in the manner set out in Schedule
2; 

  

	3.3	 THIRDLY by way of additional rent the Insurance Rent from time to time payable within fourteen (14) days of demand 

 

	3.4	 AND FOURTHLY by way of additional rent the Tenant’ s Share of the Second Service Charge payable at the times and in the manner set out in
Schedule 6; 

  

	 	 in each case to be paid (at the option of the Landlord exercisable on any number of occasions) either by standing order, credit transfer, direct debit
mandate or cheque. 

  

	4	 TENANT’S COVENANTS 

The Tenant hereby covenants with the Landlord throughout the Term: 

 

	4.1	 Pay Rent, First Service Charge, Second Service Charge and Insurance Rent 

 

	 	 To pay the rents and the reviewed rents hereby reserved on the days and in manner aforesaid without deduction counterclaim or set-off. 

 

	4.2	 Pay Value Added Tax 

  
 9 

	 	4.2.1	 To pay (on receipt of proper VAT invoices) and keep the Landlord indemnified against all VAT which may from time to time be properly charged on the rents and
/ or any other monies payable under this Lease. 

  

	 	4.2.2	 The Landlord has exercised its option to tax (the “Landlord’s Option to Tax”) the rents payable under this Lease pursuant to
Section 97 of the VAT Act. The Tenant shall pay to the Landlord any VAT properly chargeable on the rents and any other payments reserved or payable pursuant to this Lease subject to receipt of a proper VAT invoice. 

 

	 	4.2.3	 At any time during the Term the Landlord may terminate the Landlord’s Option to Tax in respect of this Lease and shall notify each termination forthwith
to the Tenant. 

  

	 	4.2.4	 Where at any time during the Term the Landlord has terminated the Landlord’s Option to Tax, the Landlord may thereafter from time to time during the
Term exercise the Landlord’s Option to Tax the rents payable under this Lease by giving notice to the Tenant pursuant to Section 97(1)(c)(ii) and where such notice is given the Tenant shall thereafter pay to the Landlord (on receipt of
proper VAT invoices), all VAT on the rents properly payable under this Lease. 

  

	 	4.2.5	 Where, during the Term, a situation arises where the Landlord from time to time and the Tenant from time to time become connected persons within the meaning
of VAT Act and the Tenant has less than 90% VAT recovery such that the Landlord suffers a deductibility adjustment under VAT Act, then the Tenant will reimburse, and indemnify the Landlord on a net of tax basis, the amount of the deductibility
adjustment. In the event of a later refund or credit to the Landlord from the Revenue Commissioners of any sum or part thereof paid by the Tenant pursuant to this clause or clause 4.18.9 the Landlord shall pay such sum or part thereof as appropriate
so received to the Tenant within 14 days of receipt. For the purposes of this clause 4.2.5 “Tenant” shall mean the party who has made the actual payment to the Landlord pursuant to this clause or to clause 4.18.9 and not (unless paid by
same) any successor in title to the Tenant. The Landlord further acknowledges and agrees that where the Landlord’s Option to Tax is terminated the Landlord shall during the term of this lease avail in so far as it is able of the next
opportunity to re-exercise the Landlord’s Option to tax and shall use reasonable endeavours to procure that any claim for a credit or refund of VAT due to the Landlord as a result of such re-exercise is processed expeditiously.

  

	 	4.2.6	 Notwithstanding any other provision of this Lease, the Landlord agrees that strictly subject to the Tenant providing it with a valid authorisation under
Section 56(3) of the VAT Act, it shall (i) apply the zero rate of VAT to the rents and to any other payments reserved or payable by the Tenant pursuant to this Lease; and (ii) provide the Tenant with a valid VAT invoice in accordance
with Chapter 2, Part 9 of the VAT Act in respect of any taxable supplies made by it to the Tenant. If the Landlord charges VAT incorrectly in respect of any taxable supplies made by it to the Tenant, the Landlord and the Tenant agree that they will,
in a timely manner, take such action as may be necessary to ensure that a correct invoice is issued. However, in the event that the Landlord has not been furnished with an authorisation under Section 56(3) of the VAT Act as aforesaid at any
time, it shall be entitled to apply the full rate of VAT applicable to the said rents or other payments. 

  

	 	4.2.7	 The landlord covenants that it is at the date of the execution of this Lease, and shall continue to be, an accountable person for the purposes of Part 2, of
the VAT Act. 

  
 10 

	 	4.2.8	 In the event of an agreed surrender of this Lease for any reason (excluding by way of forfeiture or ejectment), and if at the date of such agreed Surrender
(if any) either the Tenant or one of its predecessors in title has created a Capital Good in respect of the Premises the Landlord shall agree at that time to co-operate with the Tenant and may if, reasonable, enter into an agreement in writing to
become responsible for any such Capital Good from the date of the surrender of this Lease in accordance with Section 64(7) of the VAT Act and if applicable the Tenant shall issue to the Landlord a copy of the Tenant’s Capital Goods Record
in accordance with Section 64(7) of the VAT Act PROVIDED ALWAYS that the Landlord shall not be required to enter into such an agreement in circumstances where becoming responsible for the refurbishment Capital Good would cause an
irrecoverable VAT cost for the Landlord (either as a VAT clawback or a VAT payment obligation). 

  

	4.3	 Interest on late payments 

Without prejudice to any other right or remedy or power contained in this Lease otherwise available to the Landlord, in the event that
any of the rents hereinbefore reserved (whether formally demanded or not) or any other sums payable by the Tenant to the Landlord under this Lease are not received by the Landlord within fourteen (14) days after the due date for payment, to pay
interest on such rent or sum at the Prescribed Rate calculated for the period commencing on the due date for payment and ending on the date the rent or sum is received by the Landlord (both before and after any judgement). 

 

	4.4	 Pay Rates and Outgoings 

  

	 	4.4.1	 To pay and discharge all rates water rates taxes duties charges assessments impositions burdens and outgoings of an annual or recurring nature and also of a non-annual or non-recurring nature where the same are legally chargeable against the Tenant or occupier and whether Parliamentary or Local or of any other description that may
be assessed charged or imposed upon the Premises or the owner or occupier in respect thereof during the Term (excluding any tax payable by the Landlord upon any of the rent herein received or occasioned by any disposition of or dealing with the
reversion of this lease or any capital or income taxes payable by the Landlord) and to refund to the Landlord any such amounts paid by it in respect of the Premises PROVIDED THAT no VAT shall be payable by the Tenant to the Landlord solely under
this clause 4.4.1 but, for the avoidance of doubt, this proviso shall not affect the Tenant’s liability to pay VAT in accordance with clauses 4.2, 4.18 or any other provision in this lease. 

 

	 	4.4.2	 To be solely responsible for and promptly pay all charges for water gas electricity or heat (if any) or any other utility used or consumed in the Premises
during the Term but so that the Landlord shall not be liable in any event for any interruption or failure in the supply of any such utilities to the Premises. 

 

	4.5	 Comply with Enactments 

At its own expense to observe and comply with all Enactments and to do and execute all such works as are or shall be at any time during
the Term under or by virtue of all Enactments and by any local or other authority directed or required to be done or executed in respect of the Premises or any part thereof whether by the owner or occupier thereof and to indemnify and keep the
Landlord indemnified against all or any claims demands and liability in respect thereof. 
  

	4.6	 Alterations 

  

	 	4.6.1	 Not to erect or to permit or suffer to be erected any new building upon the Premises or to make or to permit or suffer to be made any external or structural
alteration in or addition whatsoever to the Premises; 

  
 11 

	 	4.6.2	 (Without prejudice to Clause 4.6.1) not without the previous consent in writing of the Landlord (such consent not to be unreasonably withheld or delayed) to
make any other alterations or additions to the Premises or any alterations or additions to any Landlord’s fixtures, fittings or equipment or the Conduits. 

 

	 	4.6.3	 (Without prejudice to Clause 4.6.1) not without the previous consent in writing of the Landlord (not to be unreasonably withheld or delayed) to erect any
partitioning or carry out any other internal non-structural alteration within the Premises and any such erection or alteration for which consent is granted shall be carried out in accordance with plans and specifications to be first approved by and
to the reasonable satisfaction in all respects of the Landlord’s Architects or Surveyors and the Tenant shall pay the reasonable charges for such Architects or Surveyors and of the Landlord’s Solicitors incurred for each such consent.

  

	 	4.6.4	 To furnish to the Landlord on completion of any permitted alterations certificates of compliance with or exemption from all relevant planning and building
control legislation from competent and suitably professionally qualified persons acceptable in accordance with prudent conveyancing standards such certificates to be in the form then currently approved by the Law Society of Ireland.

  

	 	4.6.5	 It shall be reasonable for the Landlord to impose as a condition of any consent granted pursuant to this Clause 4.6 that the Tenant shall reinstate the
Premises at the expiration or sooner determination of the Term to its condition prior to any alterations being carried out or if so required by the Landlord in accordance with the Landlord’s Specification. 

 

	 	4.6.6	 Without prejudice to the generality of Clause 4.5: 

  

	 	(a)	 if the original of the Safety File for the Premises is provided to the Tenant on the request of the Tenant, to maintain and keep safe the Safety File and to
amend and update the Safety File when necessary in respect of any alterations carried out by the Tenant from time to time, and to furnish the original Safety File to the Landlord upon request if required by the Landlord in connection with a dealing
relating to the Landlord’s interest in the Premises; or 

  

	 	(b)	 in the event that the Safety File for the Premises is retained elsewhere or forms part of the Safety File for the Building, to provide to the Landlord within
thirty (30) days of any such alterations all information and documentation required to allow the Landlord to amend and update the Safety File when necessary in respect of any alterations carried out by the Tenant from time to time.

  

	 	4.6.7	 The Landlord may as a condition to giving any consent under any of the sub-clauses in this clause 4.6 or where the provisions of this clause
4.6 are deemed to apply require the Tenant to enter into such covenants and licences, to provide and maintain such insurances and to comply with such requirements as the Landlord shall reasonably require in relation to the execution of any
works, their repair and maintenance and their removal and the reinstatement of the Premises on termination of the Term or otherwise and any consent under or by virtue of any of the sub-clauses in this clause 4.6 shall be subject to the Tenant
complying with the Planning Acts (including Building Regulations) and any other applicable Act. 

  

	4.7	 Not To Avoid Insurance 

  

	 	4.7.1	 Not to knowingly do or permit or suffer upon or bring or suffer to be brought on to the Premises any matter or thing or article which shall or may cause the
policy or policies for the insurance of the Premises or of any adjoining or neighbouring premises or any part thereof to become void or voidable or the premium or 

  
 12 

	 	 
premiums payable in respect of the said policy or policies to be increased above the ordinary or common rate applicable to the Premises or any adjoining or neighbouring premises and if the
premium or premiums are so increased or if the Landlord so incurs expenses in the renewal of any policies as a result of the Tenant’s breach to pay the same to the Landlord on demand; 

 

	 	4.7.2	 In the event of the Premises, or any other premises in the Building or any part thereof being destroyed or damaged from or by any of the Insured Risks and
the whole or part of the insurance money in respect of the same being irrevocably by reason solely or in part then and in every such case the Tenant shall forthwith pat to the Landlord the whole or (as the case may require) a fair proportion of the
cost of rebuilding and reinstating the Premises and any other premises in the Building in respect of which the Landlord’s insurance shall be vitiated by the act, neglect or default of the Tenant. 

 

	4.8	 Repair Maintain and Keep Tidy 

  

	 	4.8.1	 To repair maintain, renew and keep in good and substantial repair and condition the Premises and, as often as may be necessary, to reinstate or renew any
part of parts of the Premises and as and when necessary, to replace any Landlord’s fixtures and fittings in the Premises which become beyond repair, excluding damage by any Insured Risk (unless the insurance money shall have been rendered
irrecoverable or insufficient in whole or in part due to the act, neglect or default of the Tenant or of any person deriving title under or through it or their respective servants, agents or invitees). 

 

	 	4.8.2	 To keep the Premises clean and tidy and free from deposits of material or refuse and not to bring or keep or suffer to be brought or kept on the Premises or
any part of any of them any dump or rubbish or scrap heap or anything which in the opinion of the Landlord is or may become unclean, unsightly, noisome or offensive or liable to detract from the quality, amenity or reputation of the Building or any
adjoining premises of the Building as a high quality office and so often as it shall be necessary or desirable to remove from the Premises all such refuse rubbish and scrap which may accumulate or be there. 

 

	4.9	 Decoration 

 Without
prejudice to the generality of the clauses 4.8.1 and 4.8.2 above to paint with two coats at least of good quality paint all the interior of the Premises as are usually painted in a good and workmanlike manner such painting of the inside parts to be
carried out not less than once in every fifth year of the Term the last such painting to be in the year immediately preceding the termination of this Lease and at the same time with every said inside painting to paper grain and varnish and colour
such parts of the inside of the Premises as are usually or have been previously papered grained varnished or coloured. 
  

	4.10	 Permit Inspection 

  

	 	4.10.1	 To permit the Landlord and its agents and workmen with all necessary appliances to enter upon the Premises at all reasonable times after giving not less than
24 hours prior written notice (save in the case of emergency when no notice shall be required) to the Tenant for the purpose of viewing the condition thereof taking a schedule of the fixtures and fittings therein inspecting any works in progress or
of exercising any of the rights described in Part III of Schedule 1 and upon written notice given by the Landlord to execute any repairs lawfully required by such notice for which the Tenant is liable under the provisions hereof and if the Tenant
shall not execute such repairs within 21 days of the date of the service upon it of such notice (or if there is any emergency then within such lesser period as may be reasonably practicable but in such event without any delay whatsoever) the
Landlord may itself execute such 

  
 13 

	 	 
repairs and the costs incurred by it in so doing shall be paid by the Tenant to the Landlord upon demand and shall be a debt recoverable from the Tenant by the Landlord in any court of competent
jurisdiction; 

  

	 	4.10.2	 To pay to the Landlord on demand all fees and expenses vouched and properly incurred by the Landlord and / or its servants and agents in connection with the
preparation of any notice pursuant to this sub-clause whether during or after the expiration or sooner determination of the Term. 

  

	4.11	 Permit Landlord’s Works 

  

	 	4.11.1	 To permit the Landlord and all persons authorised by it and their officers employees agents contractors licensees and workmen at all reasonable times after
reasonable prior notice (except in case of emergency when no notice shall be required) to enter (and if necessary to erect and maintain equipment and scaffolding) upon the Premises with all necessary appliances: 

 

	 	(a)	 to execute repairs, alterations, painting, redecoration or other work to the Premises or any other part of the Building; and 

 

	 	(b)	 for the purpose of inspecting, repairing, renewing, cleansing, emptying, maintaining or protecting any Conduits in under or over the Premises in connection
with or for the accommodation of any adjoining or neighbouring premises. 

  

in either case the person or persons exercising such rights making good or paying compensation for any damage (other than consequential
loss or damage) thereby occasioned to the Premises or any Tenant’s fixtures and fittings. 
  

	4.12	 Nuisance 

 Not to carry
on or permit or suffer to be carried on upon any part of the Premises any offensive or noisy trade business manufacture or occupation or permit or suffer the Premises to be used for any illegal purposes nor to do or permit or suffer to be done in or
upon the Premises anything which in the opinion of the Landlord may be a nuisance annoyance or disturbance or to cause damage or interference to the beneficial occupation of the occupants of the Building and to diligently and expeditiously execute
all such works as soon as possible as may be necessary for abating any such nuisance in obedience to a notice lawfully served by a local or public authority or pursuant to any court order or in obedience to any notice properly served by the Landlord
pursuant to this Clause 4.12 and in default thereof to pay to the Landlord all reasonable and properly vouched costs charges and expenses which may be incurred by the Landlord in abating such nuisance in respect of the Premises. 

 

	4.13	 Prevent Encroachment 

To use all reasonable endeavours to prevent any easement or right belonging to or used with the Premises from being obstructed or lost
and not to allow any encroachment to be made or easements to be acquired on under or over the Premises and to give notice to the Landlord forthwith of any encroachment which might have that effect and to join in at the cost of the Landlord with any
objection or proceedings which the Landlord may take in respect of such encroachment. 
  

	4.14	 Signs 

  

	 	4.14.1	 Not to paint fix or exhibit or permit or suffer to be painted fixed or exhibited so as to be visible from outside the Premises any advertisement notice sign
placard hoarding name or writing to or upon any part of the exterior of the Premises or on or in the windows or external walls of the Premises or upon any entrance doors thereof, save

  
 14 

	 	 
that the Tenant may, with the prior consent in writing of the Landlord (not to be unreasonably withheld), display and maintain in the lift lobby on the first floor of the Building immediately
outside the Premises, and on the board in the Reception maintained for that purpose and any other tenant directories maintained by the Landlord in the Building or the curtilage thereof, a name-plate or sign showing the usual trade name of every
permitted occupier of the Premises and may install signage identifying the Tenant’s car spaces in the Basement PROVIDED ALWAYS that in connection with any such consent which may be given as aforesaid any necessary consent of the
appropriate authorities under any planning or other legislation be also first obtained by the Tenant. 

  

	 	4.14.2	 Not to hang or place or exhibit or permit or suffer to be hung or placed or exhibited any goods outside the Premises or the entrance doors or display windows
of the Premises. 

  

	 	4.14.3	 Not to install any blinds or curtains in the windows of the Premises or to substitute such blinds or curtains from time to time without first obtaining the
prior written consent of the Landlord. 

  

	4.15	 Aerials 

 Not without
the prior written consent of the Landlord (not to be unreasonably withheld) to erect or permit the erection of any television or radio or telecommunication receiving aerials or antennae or other apparatus on the exterior of the Premises. 

 

	4.16	 Reletting Signs and Viewing 

  

	 	4.16.1	 To permit the Landlord during the six months immediately preceding the expiration of the Term to affix and retain without interference to or upon any part of
the Premises (but so as not unduly to obscure the windows thereof or interfere with the Tenant’s use thereof) a notice for reletting the same and during the said six months to permit persons with written authority from the Landlord or its
agents at reasonable times of the day (upon reasonable prior written notice) to view the Premises; 

  

	 	4.16.2	 To permit upon reasonable prior written notice at all reasonable times during the Term hereof prospective purchasers of or dealers in or agents instructed in
connection with the sale of the Landlord’s reversion or of any interest superior to the Term to view the Premises without interruption provided the same are authorised in writing by the Landlord or its agent. 

 

	4.17	 Cost of notices and consents 

To give immediate notice thereof to the Landlord of any notice or claim affecting the Premises and to pay all costs charges and expenses
(including Solicitors’ costs and surveyors’ fees) vouched and properly incurred by the Landlord: 
  

	 	4.17.1	 for the purpose of or incidental to or in contemplation of the preparation and service of a notice under Section 14 of the Conveyancing and Law of
Property Act 1881 requiring the Tenant to remedy a breach of any of the covenants herein contained notwithstanding forfeiture for such breach shall be avoided otherwise than by relief granted by the Courts; 

 

	 	4.17.2	 in connection with the enforcement (whether during or after the expiry of the Term) of the Tenant’s obligations under this Lease including the
preparation and service of all notices and schedules of dilapidations; 

  

	 	4.17.3	 in respect of each application for consent licence or approval under this Lease whether or not the application is withdrawn or rejected.

  
 15 

	4.18	 Alienation 

  

	 	4.18.1	 Not to assign underlet or part with or share the possession control or occupation of the whole or any part of the Premises save in accordance with this
clause 4.18; 

  

	 	4.18.2	 Not to assign underlet or part with or share the possession or control or occupation of the whole or any part of the Premises without the consent in writing
of the Landlord first obtained such consent not to be unreasonably withheld or delayed to a respectable and responsible assignee or underlessee of good and sufficient financial standing (taking into account the financial obligations under this Lease
or an appropriate proportion of such financial obligations in the case of an underlease of part only) and equal or greater financial standing to the existing tenant proof of which is furnished to the Landlord and upon any such assignment to obtain
if the Landlord shall so require an acceptable guarantor or guarantors who shall if required by the Landlord enter into a direct covenant in the same form (mutatis mutandis) as that contained in Schedule 5 for any assignee and subject to the
following provisions or such of them as may be appropriate, that is to say: 

  

	 	4.18.3	 The Tenant shall prior to any such assignment or underlease apply to the Landlord and give all information concerning the proposed assignee or underlessee as
the Landlord may reasonably require. 

  

	 	4.18.4	 The Landlord’s consent to any such assignment or underletting shall be given in writing and the Tenant shall pay the Landlord’s reasonable costs in
connection with the application for such consent whether or not such consent is granted or refused. 

  

	 	4.18.5	 In the case of an assignment shall be of the entire of the Premises. 

 

	 	4.18.6	 In the case of an underlease 

  

	 	(a)	 the same shall be of the entire of the Premises or part of the Premises provided however that there shall be no more than two occupiers (including if still
in occupation the Tenant) of the Premises at any one time and no such underlessee shall be permitted to underlet part of the underlet premises; 

  

	 	(b)	 the sub-tenant shall pay an amount equal to the higher of (i) the then open market rack rental value for the Premises with the benefit of the Easements
Rights and Privileges at the time of the granting of such underlease (or the appropriate part thereof in the case of an underlease of part only) and (ii) the yearly rent payable under this Lease at the time of the granting of such underlease
(or the appropriate part thereof in the case of an underlease of part only); 

  

	 	(c)	 the Tenant shall procure that the sub-lessee shall execute in advance of such sub-letting, whether of all or of part only of the Premises, a Deed of
Renunciation in respect of any statutory rights of renewal which might accrue to it on the expiration of such sub-lease and shall indemnify the Landlord against any loss, cost, claim, expense, action or demand arising in respect of any breach of
that obligation or as a result of any such statutory rights of renewal nevertheless accruing to such sub tenant; 

  

	 	(d)	 unless the Landlord otherwise elects, the amount of rent charged under any such underlease(s) and any other evidence in relation to any such underlease(s)
shall be disregarded in any review of the Rent payable under this Lease pursuant to Schedule 3 

  
 16 

	 	4.18.7	 An underlessee shall if required by the Landlord enter into a direct covenant with the Landlord to perform and observe all the covenants (other than that for
payment of the rent hereby reserved) and conditions contained in this Lease (or insofar as they relate to or affect the premises underlet in the case of an underlease of part only) and every such underlease shall also be subject to the following
conditions, that is to say that it shall contain: 

  

	 	(i)	 an unqualified covenant on the part of the underlessee not to assign underlet or part with or share the possession of part only of the premises thereby
demised; 

  

	 	(ii)	 a covenant on the part of the underlessee not to assign or underlet the premises thereby demised without obtaining the previous consent in writing of the
Landlord hereto not to be unreasonably withheld or delayed; 

  

	 	(iii)	 covenants and conditions in the same terms as nearly as circumstances admit as those contained in this Lease; 

 

	 	(iv)	 a covenant, condition or proviso under which the rent reserved by the underlease shall be reviewed at the Review Date (as defined in Schedule 3 of this
Lease) 

  

	 	(v)	 a covenant, condition or proviso under which the rent from time to time payable under such underlease shall not be less than the rent from time to time
payable hereunder; and 

  

	 	(vi)	 a covenant that any underleases granted out of such underlease whether immediately or mediately shall contain provisions similar to those in this clause
4.18.7. 

  

	 	4.18.8	 It shall be reasonable for the Landlord to withhold consent to any proposed assignment, parting with or sharing of possession or control or occupation of the
Premises if such assignment or sublet, etc, would result in the termination of the Landlord’s Option to Tax under Section 97(1) of the VAT Act. 

  

	 	4.18.9	 The Tenant shall indemnify and keep the Landlord indemnified from and against all losses, costs, claims, demands, proceedings, damages, expenses and
liabilities arising out of the termination of the Landlord’s Option to Tax under Section 97(1)(d)(iii),(iv) and (v) of the VAT Act to the extent that on any such termination the Tenant shall, without prejudice to the generality of the
foregoing, pay on demand to the Landlord: 

  

	 	(i)	 an amount equal to the amount payable by the Landlord to the Revenue Commissioners under the VAT Act as a result of the termination of the Landlord’s
Option to Tax referred to in this clause; and 

  

	 	(ii)	 where the amount payable under sub-paragraph (i) above is or will be subject to tax in the hands of the Landlord such further sum as will leave the
Landlord in the same financial position as if such amount had not been subject to tax; 

  

	 	(iii)	 In respect of the above, the Landlord agrees to furnish to the Tenant a calculation of any sums due (the “Statement”) signed by the
Landlord’s auditors or tax advisors and such Statement shall (save in the case of manifest error) be final and binding on the parties. 

  
 17 

	 	4.18.10	 In the case of any permitted underlease the Tenant further covenants and agrees: 

 

	 	(a)	 to enforce at the Tenant’s own expense the performance and observance by every such undertenant of the covenants provisions and conditions of the
underlease and not at any time (either expressly or by implication) to waive any breach of the same; 

  

	 	(b)	 not to agree any adjustment or revision to the rent with the undertenant without the prior written consent of the Landlord; 

 

	 	(c)	 not to vary the terms of any permitted underlease without the prior written consent of the Landlord; and 

 

	 	(d)	 to ensure that vacant possession of the underlet premises is quietly yielded up by the undertenant at the expiration or sooner determination of the permitted
term of the underlease (and in any event on Termination of the Term) free from any claims or potential claims under the Landlord and Tenant Acts 1967 to 2010. 

 

	 	4.18.11	 In clause 4.18.7 and in clause 4.18.10 the expression “underlease” shall include an underletting as well (in an appropriate case) as
a sufferance of any person to occupy the Premises or any part of it as licensee or as concessionaire and the expression “undertenant” and “underlet premises” shall be construed accordingly. 

 

	 	4.18.12	 PROVIDED  ALWAYS and it is expressly agreed and declared that without prejudice to any other ground on which the Landlord may be entitled to
withhold or refuse its consent the Landlord shall be entitled and it shall be deemed reasonable for the Landlord to refuse its consent to any alienation if: 

  

	 	(a)	 the proposed assignee undertenant or other person as aforesaid intends to alter the user of the Premises or any part of it in a manner which would be
prohibited under the provisions of this Lease relating to permitted user of the Premises or under any superior lease or other deed or document affecting the Premises or the Landlords title; 

 

	 	(b)	 in the Landlord’s reasonable opinion there are at the date of the application for consent any material outstanding breaches of any of the covenants on
the part of the Tenant or conditions contained in this Lease; 

  

	 	(c)	 in the Landlord’s reasonable opinion the alienation is to a person Connected to the Landlord; or 

 

	 	(d)	 where the proposed assignee or undertenant or other person as aforesaid enjoys diplomatic or state immunity. 

 

	 	4.18.13	 To furnish to the Landlord or the assignee or undertenant as appropriate a capital good record in accordance with the provisions of Section 95
(9) or Section 64 (7) of the VAT Act at or prior to any permitted assignment or underlease. 

  

	 	4.18.14	 If at any time during the Term the provisions of Section 32(2) of the Local Government Reform Act 2014 apply to the Premises or any part of it to give
to the rating authority the notice provided for in sub-section 32(2)(a) of that Act within the period specified in that sub-section (with a copy to the Landlord at the same time) and to comply with the provisions of Section 32 of the said Act.

  
 18 

	 	4.18.15	 It shall be reasonable for the Landlord to require as a pre-condition to its consent that the assignee undertenant licensee concessionaire or other person
executes and delivers to the Landlord prior to or contemporaneously with the alienation in question a Deed of Renunciation such that the Landlord is satisfied that on the determination of the Term whether by effluxion of time re-entry notice
surrender (whether by operation of law or otherwise) or by any other means whatsoever of the Term (or if sooner the determination of the term of any underlease) there will be no right or entitlement to a new tenancy under Part 2 of the Landlord and
Tenant (Amendment) act 1980 as amended. 

  

	 	4.18.16	 Without prejudice to the indemnity provided for in clause 4.18.9, prior to any assignment, underlease, parting with or sharing of possession or control or
occupation of the whole Premises (hereinafter referred to as an ‘Alienation’), the Tenant shall notify the Landlord in writing prior to such Alienation in accordance with clause 14.8.3 indicating the name, address and other relevant
details as regards the proposed assignee, occupant or under-lessee in ordert hat the Landlord can establish and confirm in writing to the Tenant whether the proposed assignee, occupant or under-lessee is or is not connected with the Landlord within
the meaning of Section 97(3) of the VAT Act AND in the event of the proposed assignee, occupant or under-lessee being so connected whether the Alienation would result in a termination of the Landlord’s option to tax the Lease pursuant to
Section 97 (1)(d)(iii)(iv) or (v) of the VAT Act. In the event that the proposed Alienation would result in a termination of the Landlord’s option to tax pursuant to Section 97 (1)(d)(iii)(iv) or (v) of the VAT Act
(and the Tenant still wishes to proceed with the Alienation and the Landlord consents to such Alienation and the Tenant otherwise complies with the covenants and conditions of this clause 4.18 and this Lease in respect of such Alienation), the
Tenant shall prior to such Alienation pay to the Landlord a reimbursement amount in respect of any VAT clawback or VAT payment obligation which would be suffered by the Landlord as a result of the termination of the Landlord’s option to tax. If
this reimbursement amount is subject to Tax in the hands of the Landlord, the Tenant shall also pay, in addition to the reimbursement amount, such further sum which will leave the Landlord in the same position as if such amount had not been subject
to Tax. The Landlord shall furnish to the Tenant a calculation of the sums due under this clause 14.8.16 (the “VAT Statement”) signed by the auditors or tax advisers pursuant to Clause 14.8.9 above which VAT Statement shall, save in
the case of manifest error, be final and binding on the parties. 

  

	4.19	 Notice of Alienation 

Within one calendar month after the execution of any assignment transfer underlease or the devolution of the Premises to give notice in
writing with particulars to the Landlord’s Solicitors and to produce to them with such notice such assignment or transfer or the counterpart of such underlease or the probate or letters of administration or other instrument under which such
devolution arises. 
  

	4.20	 Disclosure of Notices 

Upon receipt of any notice order requisition direction or other thing from a competent authority affecting or likely to affect the
Premises (whether the same shall be served directly on the Tenant or the original or a copy thereof be received by the Tenant from any person whatsoever) forthwith to deliver to the Landlord a copy thereof and so far as the provisions hereof require
the Tenant so to do to comply therewith at its own expense. 
  

	4.21	 Unauthorised User 

  

	 	4.21.1	 Not to use or occupy the Premises or any part thereof or permit the same to be used or occupied for any other purpose than the Permitted Use.

  
 19 

	 	4.21.2	 Not to permit or suffer anyone to sleep in the Premises and not to use or permit or suffer the use of the same or any part thereof for residential purposes
or as licensed premises for the sale of excisable or intoxicating liquors or as an amusement arcade or bingo hall or any similar user. 

  

	 	4.21.3	 Not to use the Premises or any part thereof or permit or suffer the same to be used for gaming or as a betting office. 

 

	 	4.21.4	 Not to have or permit any sale by auction in or upon the Premises or any part thereof. 

 

	4.22	 Machinery Overloading and Inflammable Goods 

  

	 	4.22.1	 Not (except so far as the same shall be ancillary to the Permitted Use and the installation or use of the same shall not amount to a breach of any other
provision herein) to erect or install or use in or upon any part of the Premises any steam gas electric or other engine or machinery of any kind. 

  

	 	4.22.2	 Not to do or permit or bring in or upon the Premises anything which may throw on the Premises or any adjoining premises any weight or strain in excess of
that which such premises are capable of bearing with due margin for safety and in particular not to overload the floors or the electrical installations or the other services of in or to the Premises nor suspend any excessive weight from the ceilings
or walls, stanchions or the structure thereof. The Tenant shall seek professional advice at the Tenants own expense to ensure that there shall not be an infringement of this covenant. 

 

	 	4.22.3	 Not to have store or keep upon the Premises or any part thereof any substance of an explosive or of an inflammable or dangerous nature or such as might
increase the risk of fire or explosion or which might attack or in any way injure by percolation corrosion or otherwise the Premises or any adjoining premises or the keeping or use whereof may contravene any statutory or local regulation or bye-law and in particular without prejudice to the generality of the foregoing not to keep portable gas appliances for use on the Premises. 

 

	4.23	 Planning Acts 

  

	 	4.23.1	 Not to do or omit or permit to be done or omitted anything on or in connection with the Premises the doing or omission of which shall be a contravention of
the Planning Acts and / or the Building Regulations, or of any notices, orders, licences, consents, permissions and conditions (if any) served, made, granted or imposed thereunder or under any enactment repealed thereby and to indemnify (as well
after the expiration of the Term by effluxion of time or otherwise as during its continuance) and keep indemnified the Landlord against all actions, proceedings, damages, penalties, costs, charges, claims and demands in respect of such acts and
omissions or any of them and against the costs of any application for Planning Permissions obtained by the Tenant and the works and things done in pursuance thereof. 

 

	 	4.23.2	 In the event of the Landlord giving written consent to any of the matters in respect of which the Landlord’s consent shall be required under the
provisions of this Lease or otherwise and in the event of permission from any Planning Authority under the Planning Acts and / or the Building Regulations being necessary for any additions, alterations, or changes in or to the Premises or for the
change of user thereof or for any development for which such consent has been sought and obtained to apply at the cost of the Tenant to the relevant local authority for all consents and permissions which may be required in connection therewith and
to give notice to the Landlord of the granting or refusal (as the case may be) of all such approvals, certificates, consents and permissions forthwith on the receipt thereof and to comply with all conditions, regulations, bye-laws and other matters
prescribed by any competent 

  
 20 

	 	 
authority either generally or specifically in respect thereof and to carry out such works at the Tenant’s own expense in a good and workmanlike manner to the reasonable satisfaction of the
Landlord and without prejudice to the generality of the foregoing or to any other obligation of the Tenant or any other requirement of the Landlord promptly furnish to the Landlord: 

 

	 	(a)	 a copy of any commencement notice or 7 day notice (including if reasonably required by the Landlord all plans, documents, calculations, specifications,
particulars, certificates and notices accompanying it) filed with or given to the building control or other competent authority in accordance with the Building Regulations; 

 

	 	(b)	 any application for a fire safety certificate and/or disability access certificate (or other certificate under the Building Regulations) for its prior
approval (which approval shall not, subject to the provisions of clause 4.6 be unreasonably withheld or delayed); 

  

	 	(c)	 any fire safety certificate and disability access certificate (or other certificate under the Building Regulations) issued; 

 

	 	(d)	 within one month of the practical completion of the works a certificate of opinion of compliance by a member of the Royal Institute of Architects in Ireland
or Engineers Ireland (or any successor or substituted body of either) that the design and construction of the works or (as applicable) the change of use comply with the Planning Acts (including Building Regulations) and that all such works and/or
change of use have been carried out in substantial compliance with the plans lodged with the relevant applications for planning permission, a fire safety certificate and/or as applicable disability access certificate as amended by any conditions
imposed by the planning authority or building control or other competent authority; and 

  

	 	(e)	 a certified copy of the Certificate of Compliance on Completion (including if reasonably required by the Landlord, all plans, documents, calculations,
specifications, particulars and inspection plan(s) accompanying it) submitted to the building control or other competent authority in accordance with the Building Regulations together with evidence that the particulars relating to such Certificate
have been entered by the building control or other competent authority on the relevant register maintained under the Building Regulations. 

  

	 	4.23.3	 To give notice forthwith to the Landlord of any notice order or proposal for a notice or order served on the Tenant under the Planning Acts and / or the
Building Regulations and if so required by the Landlord to produce the same and at the request the Landlord and the cost of the Tenant to make or join in making such objections or representations in respect of any proposals as the Landlord may
require. 

  

	 	4.23.4	 To comply at its own cost with any notices or orders served on the Tenant in respect of matters for which the Tenant its servants or agents are responsible
hereunder and to comply with all conditions attached to any permission granted under the provisions of the Planning Acts and / or the Building Regulations. 

  

	 	4.23.5	 Not to implement any planning permission before it and any necessary fire safety certificates have been produced to and approved by the Landlord (such
approval not to be unreasonably withheld or delayed). 

  

	 	4.23.6	 If and when called upon to do so to produce to the Landlord or its surveyors all such plans, documents and other evidence as the Landlord may reasonably
require in order to satisfy itself that the provisions of this clause 4.23 have been complied with in all respects. 

  
 21 

	4.24	 To Indemnify Against Claims 

To take out and maintain at all times during the Term, with an insurer approved by the Landlord and which approval shall not be withheld
in respect of an established insurer of good repute, a Policy or Policies of Insurance covering Public Liability in an amount not less than €10,000,000 (ten million euro) and Employers liability
in respect of the Premises in each case in an amount of not less than €13,000,000 (Thirteen Million Euro) for each and every claim or series of claims arising from one occurrence and to ensure
that each of the said policies contain an “Indemnity to Principals” clause in favour of the Landlord and to produce evidence that such policies are effected valid and subsisting (by way of broker’s certificate or otherwise) and the
receipt for payment of the last premium thereon to the Landlord whenever reasonably required by the Landlord to do so on demand and to indemnify and keep indemnified the Landlord against all and any actions expenses costs claims damages and other
liabilities whatsoever in respect of the injury or death of any person or damage to any property occurring during the Term howsoever arising and in particular without prejudice to the generality of the foregoing arising directly or indirectly out
of: 
  

	 	4.24.1	 the state of repair or condition of the Premises; 

  

	 	4.24.2	 the making or exercising of any alteration to the Premises by the Tenant or any sub-tenant or state of repair or condition of such alteration;

  

	 	4.24.3	 the user of the Premises during the Term; 

  

	 	4.24.4	 any work carried out or in the course of being carried out on the Premises by the Tenant or any sub-tenant; 

 

	 	4.24.5	 any breach of the terms of this Lease on the part of the Tenant or any subtenant; 

 

	 	4.24.6	 anything now or hereinafter attached to or projecting from the Premises, 

BUT EXCLUDING any actions, proceedings, demands, claims, losses, costs, expenses, damages and liabilities solely and directly caused by any act
or neglect on the part of the Landlord, their servants or agents. 
  

	4.25	 Fire Safety Requirements 

  

	 	4.25.1	 At all times during the Term to comply with all recommendations and all requirements of the appropriate fire or local authority and the insurers in respect
of the safety and security of the Premises whether notified or directed to the Landlord and then to the Tenant or directly to the Tenant in relation to fire precautions and in particular the provision of fire screens and to comply with all the
regulations from time to time made by the Landlord in relation to fire precautions and to indemnify the Landlord against any reasonably incurred and properly vouched costs and expenses in complying with any such requirement or written
recommendation, and not to obstruct the access to or means of working any apparatus and appliance for that purpose for the time being installed in the Premises. 

 

	 	4.25.2	 If required by the Landlord for the purposes of safety or where required to comply with the recommendations or the requirements of the Insurers of the
Building to pay to the Landlord on demand the cost of providing and installing portable fire extinguishers fire hose reels or similar devices or at the Landlord’s option to install same at the Landlord’s direction and at the Tenant’s
expense. 

  

	 	4.25.3	 In the event of the Premises or any part thereof being damaged or destroyed by any of the Insured Risks to give immediate notice to the Landlord.

  
 22 

	4.26	 Not to Obstruct Pipes 

Not to stop up or obstruct or permit or suffer to be stopped up or obstructed or to suffer any oil grease or other noxious or harmful
matters or substances to enter the drains sewers gutters pipes channels and watercourses of the Premises and to employ such method for treating any deleterious effluent that may reasonably be required by the Landlord or be required by the Local
Authority before permitting such effluent to enter any such drains sewers gutters pipes channels and watercourses. 
  

	4.27	 Make Good Loss 

 To
indemnify and make good all loss sustained by the Landlord in consequence of any breach by the Tenant or any underlessee of any covenant or condition on the Tenant’s part herein contained. 

 

	4.28	 Stamp Duty 

 To pay the
stamp duty tax chargeable on the original and counterpart of this Lease. 
  

	4.29	 Yield Up 

 At the
determination of the Term whether by effluxion of time re-entry notice surrender (whether by operation of law or otherwise) or by any other means whatsoever: 
  

	 	4.29.1	 Subject to clause 4.29.2 and 4.29.3, to yield up the Premises with vacant possession in the condition set out in the Landlord’s Specification and in
such state of good and substantial repair and condition as shall be in accordance with the continued performance and observance of the Tenant’s covenants contained in this Lease and otherwise in compliance with the covenants on the part of the
tenant and conditions contained in this Lease. 

  

	 	4.29.2	 Unless and to the extent that the Landlord gives the Tenant notice in writing to the contrary to remove all alterations or additions made to the Premises by
or on behalf of the Tenant or any undertenant or occupier in a good and workmanlike manner and to procure that making good all damage caused to the Premises and any Nearby Property by such removal and/or reinstatement to the reasonable satisfaction
of the Landlord. 

  

	 	4.29.3	 To remove all chattels belonging to or used by the Tenant or any occupier and all tenant’s fixtures fittings and signs and other property belonging to
the Tenant or any occupier. 

  

	 	4.29.4	 To pay to the Landlord within fourteen days of written demand all fees and expenditure (including VAT not recoverable by the Landlord) reasonably incurred by
the Landlord after the determination of the Term whether by effluxion of time re-entry notice surrender (whether by operation of law or otherwise) or by any other means whatsoever in repairing painting reinstating treating or decorating the Premises
so as to put them into the condition commensurate with the due performance of the Tenant’s covenants contained in this Lease and additionally to pay to the Landlord within seven days of written demand mesne profits at the rate of the rents
payable immediately prior to the determination of the Term whether by effluxion of time re-entry notice surrender (whether by operation of law or otherwise) or by any other means whatsoever and all additional rents due or payable under this Lease
for the period reasonably required for such repairing painting reinstating treating and decoration of the Premises. 

  
 23 

	4.30	 Register of Companies 

In the event that the Tenant or the Guarantor is at any time a company within the meaning of the Companies Acts, 1963 to 2013 to
maintain its registration in the Companies Registration Office and not to permit same to lapse or to be struck off the Register of Companies. 
  

	4.31	 Use of Premises outside Business Hours 

  

	 	4.31.1	 The Landlord agrees that, subject to the provisions of this Clause 4.31, the Tenant shall have access to the Premises 24 hours each day during each day of
the year. 

  

	 	4.31.2	 If the Tenant shall desire, from time to time, to use the Premises outside the usual Business Hours of the Building, then (subject to the Landlord being able
to provide such staff, services and security for the Building, as the Landlord may consider necessary) the Tenant shall be entitled to use and occupy the Premises and have access thereto on the following terms and conditions: 

 

	 	(a)	 the Tenant shall make prior arrangements with the Landlord or with the Surveyor or caretaker; 

 

	 	(b)	 the Tenant shall pay to the Landlord, on demand, the reasonable costs and expenses incurred by the Landlord attributable to the Tenant’s access to and
use of the Premises outside the usual business hours of the Building or a fair proportion of such costs to the extent that other tenants are using the Building during the same hours as the Tenant; 

 

	 	(c)	 the Tenant shall, in relation to all such access and use: 

  

	 	(i)	 use only such parts of the Common Areas as Landlord shall designate; 

 

	 	(ii)	 take all proper, necessary and required action to keep the Building secure; 

 

	 	(iii)	 abide by such rules and regulations as are from time to time prescribed by the Landlord (acting reasonably) for access, use and occupation of the Building
outside usual business hours; 

  

	 	(iv)	 not permit or suffer any keys or other means of access to the Building to be in the hands of any person other than the trusted employees of Tenant or others
first approved of in writing by Landlord (acting reasonably); 

  

	 	(v)	 indemnify and keep indemnified the Landlord against all losses, claims, liabilities, demands, proceedings, costs and expenses which are directly attributable
to the Tenant’s access to and use of the Premises and the Common Areas outside usual business hours. 

  

	 	4.31.3	 The Landlord hereby reserves the right to deny the Tenant access to the Building outside of Business Hours where the Tenant fails to comply with the
provisions of this Clause 4.31. 

  

	4.32	 BER Certificate 

  

	 	4.32.1	 Where the Tenant prepares obtains commissions or procures a BER Certificate in respect of the Premises to provide to the Landlord a copy of that BER
Certificate and any recommendation report and related information free of charge within seven days of receipt and (if not apparent from that copy) supply details to the Landlord of the reference number of that BER Certificate. 

 

	 	4.32.2	 Not without the prior written consent of the Landlord to cause or permit a BER Certificate for the Premises to be invalidated or materially adversely
affected. 

  
 24 

	 	4.32.3	 To allow the Landlord to have access to all documentation data and information in the Tenant’s possession or control reasonably required to prepare any
BER Certificate for the Premises; 

  

	 	4.32.4	 To comply in respect of the Premises with any duty or obligation lawfully imposed under the EPB Regulations. 

 

	5	 LANDLORD’S COVENANTS 

The Landlord covenants with the Tenant: 
  

	5.1	 Quiet Enjoyment 

 That
the Tenant paying the rent hereby reserved and observing and performing the several covenants and stipulations herein on its part contained shall peaceably hold and enjoy the Premises during the Term without any interruption by the Landlord or any
person rightfully claiming under or in trust for it. 
  

	5.2	 Services 

 Subject to
payment by the Tenant of all sums due from the Tenant from time to time in respect of the First Service Charge and the Second Service Charge to use all reasonable endeavours to provide or procure the provision of the services referred to in Part II
of Schedule 2 and in part II of Schedule 6 PROVIDED ALWAYS that: 
  

	 	5.2.1	 The Landlord shall not be liable to the Tenant in respect of any failure by the Landlord to perform any of the services referred to in this Lease, whether
express or implied, unless and until the Tenant has notified the Landlord of such failure and the Landlord has failed within a reasonable time to remedy the same and then in such case the Landlord shall (subject to 5.2.2 and 5.2.3 below) by liable
to compensate the Tenant for the actual (but not consequential, financial or other economic) loss or damage sustained by the Tenant after such reasonable time as elapsed; and 

 

	 	5.2.2	 the Landlord shall be entitled at its discretion to cease to provide or vary any of the services referred to in Part II of Schedule 2 and in part II of
Schedule 6 if any such service shall in the reasonable opinion of the Landlord cease to be for the benefit of the Building or any part thereof or become obsolete or redundant or cease to be cost effective; and 

 

	 	5.2.3	 the Landlord shall not, in any circumstances, incur any liability for any failure or interruption in any of the services provided by the Landlord or any
inconvenience or injury to person or property arising from such failure or interruption due to mechanical breakdown, failure or malfunction, overhauling, maintenance, repair or replacement, strikes, labour disputes, shortages of labour or materials,
inclement weather or any cause or other circumstance beyond the control of the Landlord, provided that the Landlord shall use its reasonable endeavours to cause the service in question to be reinstated with the minimum of delay.

  

	5.3	 Insurance 

  

	 	5.3.1	 Subject to the Landlord being able to effect such insurance and to such terms and conditions as are normally available from the insurance market, and subject
further to reimbursement by the Tenant of the Insurance Rent from time to time, the Landlord hereby covenants with the Tenant to insure in the name of the Landlord the Building and the Premises and all Landlord’s fixtures and fittings therein
and thereon 

  
 25 

	 	 
(it being acknowledged by the Tenant that the Landlord has no obligation to insure the fixtures, fittings, equipment or other contents of the Tenant (or any sub-tenants) in the Premises) and to
keep the same insured in the full reinstatement cost (to be determined from time to time by the Landlord or its surveyors) and including an inflationary factor against damage by the Insured Risks PROVIDED HOWEVER that the Landlord shall not
be responsible to the Tenant its servants agents licensees invitees or visitors for any injury death damage destruction financial or consequential loss whether to person or property due to the state and condition of the Building or the Premises or
any part thereof or due to any act or default of any agent servant workman or other person authorised by the Landlord to enter the premises save to the extent to which the same may be insured against by the Landlord pursuant to the terms of this
Lease. 

  

	 	5.3.2	 The Landlord covenants to use reasonable endeavours: 

  

	 	(a)	 To obtain from the Landlord’s insurers a waiver of its subrogation rights (if any) against the Tenant in respect of the Premises so long as such a
waiver is available in the insurance market from reputable insurers upon reasonably commercial terms; 

  

	 	(b)	 To cause the Landlord’s insurers to provide that the insurance policy or policies in respect of the Insured Risks contain a provision that the insurance
is not invalidated by any change of occupancy or increase or risk taking place in or on the premises without the knowledge of the Landlord provided that the Landlord shall without undue delay upon the same coming to its knowledge give notice to the
insurers and the Tenant shall pay any additional premiums as may be required from the date of such increase of risk so long as such provisions are available in the insurance market from reputable insurers upon reasonably commercial terms; and

  

	 	(c)	 To notify the Tenant, as soon as reasonably practicable following implementation thereof, of any material changes to the insurance policy or policies in
respect of the Insured Risks. 

  

	5.4	 Reinstatement 

 In case
the Premises or the Building or any part thereof shall be destroyed or damaged by any of the Insured Risks then (subject to the Landlord obtaining Planning Permission and all other necessary pertinent licences and approvals) and as often as shall
happen to lay out all monies received in respect of such insurance as aforesaid as soon as practicable in or upon rebuilding, repairing or reinstating the Premises and the Building substantially in accordance with its existing plan and elevation in
a good and substantial manner unless the relevant policy shall have been vitiated or rendered less than fully effective by any act, neglect, default or omission on the part of the Tenant PROVIDED ALWAYS that in the event of the Landlord being
unable to procure reinstatement of the Premises substantially in accordance with its existing plan and elevation due to refusal of planning or other approvals consents or licences the Tenant agrees to surrender this Lease when called upon by the
Landlord to do so whereupon the said insurance monies shall belong absolutely to the Landlord, but without prejudice to any claim by either party against the other in respect of any antecedent breach of covenant. 

  
 26 

	6	 PROVISOS 

Provided Always and it is hereby expressly agreed as follows: 

 

	6.1	 Re-entry 

 If: 

 

	 	6.1.1	 the rents hereby reserved or any part thereof shall at any time be in arrear and unpaid for fourteen (14) days after the same shall have become due
(whether any formal or legal demand therefor shall have been made or not); or 

  

	 	6.1.2	 the Tenant shall at any time fail or neglect to commence to perform or observe any of the covenants conditions or agreements herein contained and on its part
to be performed and observed; or 

  

	 	6.1.3	 the Tenant or the Guarantor (either or both being a body corporate, or if more than one body corporate then any one of them) shall compound or arrange with
creditors or go into liquidation either compulsorily or voluntarily or has a winding-up petition presented against it or passes a winding-up resolution (other than in connection with a members voluntary winding up for the purposes of a solvent
amalgamation or reconstruction first approved by the Landlord) or resolves to present its own winding-up petition or is wound-up (whether in Ireland or elsewhere) or a provisional liquidator is appointed or a receiver or statutory receiver or
receiver and manager or administrator is appointed in respect of the Premises or any part of it or any of the assets or undertaking of the Tenant or the Guarantor; or 

 

	 	6.1.4	 the Tenant or the Guarantor (either or both being a body corporate, or if more than one of them) permit or suffer to be appointed any examiner or interim
examiner or administrator; or 

  

	 	6.1.5	 the Tenant or the Guarantor shall be unable or admits its inability to pay its debts as they fall due; or 

 

	 	6.1.6	 the Tenant or the Guarantor (either or both being a body corporate) shall be struck off the register in the Companies Registration Office or is dissolved and
is not re-instated within 30 days; or 

  

	 	6.1.7	 the Tenant or the Guarantor (either or both being an individual or firm or if more than one individual or firm then any one of them) commits an act of
bankruptcy for the purposes of Section 7 of the Bankruptcy Act 1988 or shall become bankrupt or has a bankruptcy petition presented against him or it (in each case whether in Ireland or elsewhere) or is insolvent within the meaning of the
Personal Insolvency Act 2012 or suffers any distress or execution to be levied on the Premises or compounds or arranges with his or its creditors or shall have a receiving order made against him or it; or 

 

	 	6.1.8	 the Tenant or the Guarantor, being a Company incorporated outside the Republic of Ireland is the subject of any proceedings or event analogous to those
hereinbefore referred to in its country of incorporation; or 

  

	 	6.1.9	 the Tenant or the Guarantor (either or both being an individual) dies or becomes incapable of managing his affairs 

then and in any such case it shall be lawful for the Landlord or any person or persons duly authorised by it into or upon the Premises
or any part thereof in the name of the whole to re-enter and the Premises peaceably to hold and enjoy thenceforth as if this Lease had not been made without prejudice to any right of action or remedy of either
party in respect of any antecedent breach of any of the covenants by either party hereinbefore contained. 
  

	6.2	 Suspension of Rent 

 In
the event of the Premises or any part thereof being damaged or destroyed by any of the Insured Risks from time to time so as to render the Premises unfit for occupation and use or inaccessible, then (unless in the case of damage or destruction by
the Insured Risks the insurance monies shall be irrecoverable in whole or in part by reason solely or in 

  
 27 

 
part of any act or neglect or omission of the Tenant) the rent hereby firstly reserved and the First Service Charge and the Second Service Charge or a fair proportion of them according to the
nature and extent of the damage sustained shall be suspended until the Premises and the Building or any part thereof shall again be rendered fit for occupation and use and accessible or for the period of four years from the date of such destruction
or damage whichever is the shorter and in the event of any dispute concerning the provisions of this sub-clause the same shall be determined by a single arbitrator in accordance with the provisions of the
Arbitration Act 2010 and in the event that such reinstatement continues to be prevented after the said four years then either the Landlord or the Tenant shall be entitled at any time after the expiry of the said period of four years to determine
this Lease by serving written notice to that effect on the other and upon service of which notice this Lease shall immediately cease and determine but without prejudice to any claim by either party against the other in respect of any antecedent
breach hereof. 
  

	6.3	 Pre-Emption 

 In the
event that the Tenant wishes to assign its interest in the Lease or underlet the Premises at any time during the Term (save by way of permitted mortgage or charge to any bank or financial institution or by sharing occupation of the Premises in
accordance with Clause 4.18.16 of this Lease) then the following provisions shall apply: 
  

	 	6.3.1	 In such circumstances the Tenant shall serve on the Landlord a written notice to this effect (the “Sale Notice”) containing in full the
terms on which the Tenant wishes to assign this Lease or as the case may be underlet the Premises, and offering to assign or underlet this Lease to the Landlord for the same consideration. 

 

	 	6.3.2	 If the Landlord wishes to accept the offer made in the Sale Notice it will do so by serving on the Tenant a written notice (the “Acceptance
Notice”) within 15 Working Days of receipt of the Sale Notice by the Landlord (the “Offer Period”). The Sale Notice will be deemed to have been received by the Landlord two Working Days after service by post and the next
Working Day after service by hand. On the date of receipt by the Tenant of the Acceptance Notice (such notice will be deemed to have been received by the Tenant two Working Days after service by post and the next Working Day following service by
hand) a binding contract shall then have been constituted between the Tenant and the Landlord for the assignment by the Tenant of its interest in this Lease or as the case may be the underletting by the Tenant of the Premises to the Landlord on the
terms set out in the Sale Notice. 

  

	 	6.3.3	 If the Landlord does not serve an Acceptance Notice during the Offer Period, then the Tenant may at any time during the period of five (5) months from
the date of expiry of the Offer Period (the “Transfer Period”) market the Lease or seek to underlet the Premises with a view to securing an offer from a bona fide arms-length third party. 

 

	 	6.3.4	 If the Tenant secures an offer from a bona fide arms-length third party which is consistent with or in excess of the offer contained in the Sale Notice then,
but strictly subject to the other provisions of this clause 6.3 and the provisions of clause 4.18, the Tenant may assign its interest in this Lease or as the case may be underlet the Premises to such third party at any time during the Transfer
Period on the terms of such offer PROVIDED ALWAYS that the Transfer Period shall be deemed to be automatically extended by the period equivalent to the time elapsing between the date of the Tenant’s application to the Landlord for consent to
the assignment under clause 4.18 of this Lease and the date at which the Landlord formally responds to such application (whether by way of consent, refusal or request for further information). 

 

	 	6.3.5	 If the offer obtained by the Tenant is less than that contained in the Sale Notice but the Tenant wishes nevertheless to accept it, then the Tenant shall
serve on the Landlord a further written notice (the “Further Sale Notice”) containing full details 

  
 28 

	 	 
of such lower offer. If the Landlord wishes to accept the offer made in the Further Sale Notice it may do so by serving on the Tenant an Acceptance Notice within twelve (12) Working Days of
the date of receipt by the Landlord of the Further Sale Notice. The Further Sale Notice will be deemed to have been received by the Landlord two Working Days after service by post and the next Working Day after service by hand. On the date of
receipt by the Tenant of the Acceptance Notice (such notice will be deemed to have been received by the Tenant two Working Days after service by post and the next Working Day following service by hand or by confirmed fax) a binding contract shall
then have been constituted between the Tenant and the Landlord for the assignment by the Tenant of its interest in this Lease or as the case may be the underletting of the Premises by the Tenant to the Landlord on the terms set out in the Further
Sale Notice. 

  

	 	6.3.6	 If the Landlord does not serve an Acceptance Notice within the period specified in clause 6.3.5 above following receipt of the Further Sale Notice, then the
Tenant may at any time during the Transfer Period or a period of five months from the date of the Further Sale Notice (whichever period is longer), but strictly subject to the other terms and conditions of this clause 6.3 and of clause 4.18, assign
its interest in this Lease or underlet the Premises to the relevant third party. 

  

	 	6.3.7	 The procedure set out in this clause 6.3 will be repeated whenever the Tenant wishes to assign its interest in this Lease or underlet the Premises during the
Term. 

  

	 	6.3.8	 Whenever a binding contract for the sale of this Lease shall be constituted between the Tenant and the Landlord pursuant to this clause 6.3, the sale shall
be governed by the provisions of the then current conditions (special and general) of sale as recommended by the Law Society of Ireland (which expression shall include any substitute or successive body). 

 

	6.4	 Notices 

  

	 	6.4.1	 Any demand or notice required to be given to, or served on the Tenant the Guarantor shall be duly and validly served if addressed to the Tenant or the
Guarantor (as the case may be and, if the Tenant or the Guarantor constitutes more than one person, then addressed to any of them) and delivered personally, or sent by pre-paid registered or recorded delivery mail, or sent by facsimile transmission
addressed (in the case of a company) to its registered office, or (whether a company or individual) to its last known address, or (in the case of a notice to the Tenant) to the Premises. 

 

	 	6.4.2	 Any notice required to be given or served on the Landlord shall be sufficiently served if sent by pre-paid registered or recorded delivery mail, addressed:

  

	 	(a)	 For as long as the Lessor’s interest herein is vested in the parties named as Landlord at the start of this Lease, to: 

 

	 	 	 John Ronan and Castle Cove Property Developments Limited 

	 	 	 Treasury Building 

	 	 	 Lower Grand Canal Street 

	 	 	 Dublin 2 

  

	 	 	 or such other address as shall have been notified in writing to the Tenant for the purpose of service of notices on the Landlord; and 

 

	 	(b)	 otherwise, (in the case of a company) to the Landlord’s registered office, or (in the case of an individual) to its last known address.

  

	 	6.4.3	 A Notice sent by post shall be deemed to have been given forty-eight hours after the time of posting to the address
to which it was sent. 

  
 29 

	6.5	 Plans 

 The Plans
annexed to this Lease and the details shown thereon shall be for the purpose of identification only and no warranty or condition expressed or implied shall be given or be deemed to be given in respect of such Plans or the details shown thereon or
any matter or thing shown thereon or referred to. 
  

	6.6	 Waiver of Right to Surrender 

In case the Premises or any part thereof shall be destroyed or become ruinous and uninhabitable or incapable of beneficial occupation or
enjoyment by or from any of the Insured Risks during the Term the Tenant hereby absolutely waives and abandons its rights (if any) to surrender this Lease under the provisions of Section 40 of the Landlord & Tenant Law Amendment,
Ireland, Act 1860 or otherwise. 
  

	6.7	 No Warranty 

 Nothing
in this Lease contained shall be deemed to constitute any warranty by the Landlord that the Premises or any part thereof are authorised under the Planning Acts or otherwise for use for any specific purpose. 

 

	6.8	 Consents, Agreements etc. of Landlord 

No consent, agreement, variation, waiver or approval under this Lease or modification of this Lease shall bind the Landlord unless same
is in writing duly signed and executed by a duly authorised officer of the Landlord (or by a person duly authorised in writing by the Landlord). 
  

	6.9	 No Continuing Liability 

The obligations of the Landlord under this Lease are personal to and shall be fully binding on the owner of the reversion to this Lease
from time to time but shall not be enforceable against any person who has owned the reversion after that person has parted with all interest in it (except in relation to any period when that person was actually the owner of the reversion to this
Lease). 
  

	6.10	 Severance 

 In the
event that any covenant or condition contained in this Lease shall be determined to be void or unenforceable in whole or in part for any reason whatsoever such unenforceability or invalidity shall not affect the enforceability or validity of the
remaining covenants and conditions or parts of it and such void covenants or conditions shall be deemed to be severable from any other covenants and conditions or parts of it. If any covenant or provision contained in this Lease shall be determined
to be void or unenforceable in whole or in part by reason of the area, scope, duration or type of restriction covered by the said covenant the same shall be given effect to in such reduced or modified form as may be decided as reasonable by any
Court of competent jurisdiction. 
  

	6.11	 No Set-Off 

 The Tenant
shall not be entitled to make any counterclaim in respect of or set off against any payments due or payable to the Landlord under this Lease or otherwise and agrees to make all such payments in full irrespective of any set-off or any counterclaim of
any nature. 

  
 30 

	6.12	 No Waiver 

 If the
Landlord accepts or demands the rents reserved by this Lease or other sums reserved or made payable under this Lease after the Landlord or its agents have become aware of or have had notice of any breach, non-performance or non-observance of any of
the covenants on the part of the Tenant (or any undertenant or other occupier) or conditions contained in this Lease or any underlease, such acceptance of or demand for the rent or any other additional rents or sums will not waive any such breach,
non-performance or non-observance or any of the Landlord’s rights or remedies under or by virtue of the Lease or otherwise (including without limitation any rights of forfeiture or re-entry) and the breach, non-performance or non-observance
will be a continuing breach, non-performance or non-observance of the covenants or conditions in question so long as it continues and the acceptance of or demand for any rent reserved by this Lease or any additional rents or any such sums shall not
be a defence in any action or proceeding by or on the part of the Landlord. 
  

	6.13	 Jurisdiction 

 This
Lease shall be governed by and construed in all respects in accordance with the Law of the Republic of Ireland and the Irish Courts shall have exclusive jurisdiction in relation to any disputes arising under or connected with this Lease and the
Tenant and any Guarantor agree that any process may be served on them by leaving a copy of the relevant document at the Premises PROVIDED HOWEVER that the Landlord shall retain the right at its sole election to sue the Tenant and any
Guarantor elsewhere including in the Courts of the Landlord’s and / or the Tenant’s and / or the Guarantor’s domicile. 
  

	6.14	 Measurement 

 It is
agreed that for the purposes of this Lease that the net lettable area of the Premises (excluding Car Spaces) is 10,266 square feet (ten thousand two hundred and sixty six square feet). 

 

	7	 TENANT’S BREAK OPTION 

  

	7.1	 The Tenant shall have the right to terminate this Lease on the Break Option Date subject to the following terms and conditions: 

 

	 	7.1.1	 The Tenant shall give the Landlord no less than nine (9) months prior notice in writing of its intention to exercise the said right (the “Option
Notice”) (and in this regard time shall be of the essence); and 

  

	 	7.1.2	 On the Break Option Date the Tenant shall deliver the Premises to the Landlord free from any claims under the Landlord and Tenant Acts, 1967 – 2010 with
no person (whether the Tenant or any other person) being in occupation of the Premises or any part of the Premises and on the basis that neither the Tenant nor any other person has any claim right or licence of any kind to possess or occupy the
Premises or any part of the Premises; and 

  

	 	7.1.3	 The Tenant shall continue to be responsible for the rents and all additional rents and all other payments and outgoings payable on foot of this Lease up to
the Break Option Date; and 

  

	 	7.1.4	 Any such termination shall be without prejudice to any antecedent breach by either the Landlord or Tenant of any of their respective covenants herein
contained; and 

  

	 	7.1.5	 Subject to the provisions of this Lease the Tenant shall pay to the Landlord all VAT (if any) which it is obliged to pay under the VAT Act and arising on the
termination of the Lease. 

  

	7.2	 Without prejudice to the provisions of Clause 7.1, the Tenant shall perform and observe all the covenants and conditions contained in this Lease and on its
part to be performed and 

  
 31 

	 	 
observed up to the relevant Break Option Date, notwithstanding which, for the avoidance of doubt, failure of the Tenant to comply with this covenant shall not result in the loss of the
break option provided for in Clause 7.1 save where such failure is a breach of one, several or all of clauses 7.1.1, 7.1.2, 7.1.3 or 7.1.5 which shall be a breach resulting in loss of the break option provided for in this clause 7.

  

	7.3	 In the event that and strictly subject to the Tenant serving a written notice (the “Statement Notice”) on the Landlord no less than six
(6) months prior to the Break Option Date (and in this regard time shall be of the essence) requiring the Landlord to send to the Tenant a written statement setting out such payments as must be made pursuant to clause 7.1.3 not later than 14
days before the Break Option Date (the “Statement”) (to the intent that if the Tenant fails to send the Statement Notice, the Landlord will have no obligation to send the Statement), the Landlord will, not later than 14 days before
the Break Option Date, send to the Tenant the Statement. 

  

	7.4	 If the Lease is determined under this clause 7 above, the Landlord shall within a reasonable period of the Break Option Date repay to the Tenant a due
proportion (on a daily basis) of any payments made under clause 7.1.3 paid in advance in respect of any period after the Break Option Date. 

  

	8	 GUARANTOR COVENANTS 

  

	8.1	 In consideration of this Lease having been entered into at its request, the Guarantor covenants with the Landlord, as a primary obligation, in the terms set
out in Schedule 5. 

  

	8.2	 The Guarantor irrevocably consents to any process in any legal action or proceedings arising out of or in connection with this Lease being served on it in
accordance with the provisions of this Lease relating to the service of notices. Nothing contained in this Lease shall affect the right to serve process in any other manner permitted by law. 

IT IS HEREBY CERTIFIED that for the purposes of Section 29 of the Companies Act, 1990 the Landlord and / or the Tenant and / or the
Guarantor are not connected with one another in a manner which would require this transaction to be ratified by resolution of either. 
 IT IS
HEREBY CERTIFIED for the purposes of Section 31 of the Companies Act, 1990 the Landlord and / or the Tenant and / or the Guarantor are not connected with one another in a manner which would require this transaction to be ratified by
resolution of the Guarantor. 
 IN WITNESS of which this Lease has been executed as a Deed by the parties to it in the manner following and on
the date and year first above written. 

  
 32 

 SCHEDULE 1 

Part I 
 Premises 

ALL THAT portion of the Building being that part of the first floor thereof more particularly shown inlined in red on Plan 5 annexed
hereto and including: 
  

	1.	 the internal plaster surfaces and finishes of all structural or load bearing walls and columns therein or which enclose the same, but not any other part of
such walls or columns; 

  

	2.	 the entirety of all non-structural or non-load bearing walls and columns therein; 

 

	3.	 the inner half severed medially of the internal non load bearing walls (if any) that divide the same from other parts of the Building; 

 

	4.	 the floor finishes thereof and all carpets save that the lower limit of the Premises shall not extend to anything below the floor finishes except that raised
floors and the cavity below them shall be included; 

  

	5.	 the ceiling finishes thereof, including all suspended ceilings (if any) and light fittings save that the upper limit of the Premises shall not extend to
anything above the ceiling finishes except that the cavity above any suspended ceiling shall be included; 

  

	6.	 All window frames and window furniture and all glass in the windows and all doors, door furniture and door frames; 

 

	7.	 All sanitary and hot and cold water apparatus and equipment and the radiators (if any) therein and all fire fighting equipment and hoses therein exclusively
serving the Premises; 

  

	8.	 All Conduits therein and exclusively serving the same; 

  

	9.	 All landlord’s fixtures, fittings and any equipment in or on the said lands premises and buildings; and 

 

	10.	 Any additions alterations and improvements to the Demised Premises. 

Part II 
 Building 

ALL THAT the Office Building situate at 1 Burlington Road and the rere of 40/42 Mespil Road in the City of Dublin as delineated and shown for the
purpose of identification only on Plan 3 annexed hereto and thereon outlined in red. 

  
 33 

 Part III 

Exceptions and Reservations 
 Excepting and
reserving unto the Landlord and all other persons at any time authorised by them or any of them or otherwise entitled to the same rights as follows, exercisable in accordance with the provisions set out herein: 

 

	1.	 Full right and liberty to build upon and develop the Building and any adjoining premises or property now or hereafter belonging to the Landlord or to build
upon or to extend in height or otherwise such premises from time to time adjoining or adjacent to the Premises or any building or any part thereof of which the Premises form part notwithstanding that the access of light and air to the Premises and
the lights windows and openings thereof may be affected. 

  

	2.	 The free and uninterrupted passage and running of the Utilities through the Conduits which are now, or may at any time throughout the Term (or any extension
or renewal thereof) be in, on, under or passing through the Premises. 

  

	3.	 Full right and liberty at all reasonable times to enter upon the Premises with or without appliances, equipment of any sort and workmen and others as often
as may be necessary to view the state and condition of and to repair and maintain the Premises and (where same cannot reasonably be carried out at reasonable cost without accessing the Premises) clean alter renew remove or install such gutters pipes
sewers drains wires conduits ducts flues and watercourses serving the Premises and adjoining premises and the Building (including the right if necessary to erect and maintain scaffolding). 

 

	4.	 The right to erect essential scaffolding for the minimum period necessary for the purpose of repairing or cleaning the Common Areas or any adjoining property
or in connection with the exercise of any of the rights mentioned in this Schedule notwithstanding such scaffolding may temporarily interfere but not in any way materially prevent the proper access to and other enjoyment and use of the Premises.

  

	5.	 The full rights of support and of shelter and protection to adjoining premises are at present enjoyed from the Premises. 

 

	6.	 All rights of light and air and other easements and rights now enjoyed by any other part or parts of the Building or any adjoining property over the
Premises. 

  

	7.	 The full right and liberty to enter upon the Premises following the provision of at least 7 days prior written notice (save in the case of emergency when no
notice is required) at any time during the Term in order to build on or into any party or other walls of the Premises the person or persons exercising such rights making good all damage to the structure of the Premises thereby occasioned.

  

	8.	 The full right and liberty to enter upon the Premises at all reasonable times during the Term on provision of reasonable prior notice (save in cases of
emergency when no notice shall be required) to gain access to the Premises and / or to the balcony or terrace (if any) forming part of the Premises as necessary for the purposes of carrying out the services described in Schedule 2.

  
 34 

	9.	 The full right and liberty to develop the remainder of the Building or any adjoining property now or hereafter of the Landlord throughout the Term (or any
extension or renewal thereof) in such manner as the Landlord shall think fit. 

  

	10.	 The airspace above the Premises. 

  

	11.	 The full right and liberty to close off the Common Areas or any part thereof for temporary period for the purpose of repairing, maintaining, replacing and
renewing same. 

  

	12.	 The full right and liberty upon reasonable notice to the Tenant to re-locate the Car Spaces allocated to the Tenant to a different part of the Basement from
time to time. 

  

	13.	 The right to regulate and control the use of the Common Areas in accordance with the principles of good estate management and in particular (but not by way
of limitation) to: 

  

	 	(a)	 vary or to change the use of, close or control access to the whole or any part of the Common Areas; 

 

	 	(b)	 make regulations for the control, regulation and limitation of pedestrian or vehicular traffic in the Common Areas or in any part thereof and to erect such
signs as may be appropriate; 

  

	 	(c)	 the right to make rules and regulations in accordance with the principles of good estate management as follows: 

 

	 	(i)	 for the control, regulation and limitation of the traffic vehicular and otherwise into and from and within the Building and in particular regulation for the
delivery and storage of stocks and goods; 

  

	 	(ii)	 for the storage, removal and disposal of waste; 

  

	 	(iii)	 for the security of the Building as a whole or in respect of any part or parts; 

 

	 	(iv)	 for emergency action and procedure; 

  

	 	(v)	 for fire precautions. 

 PROVIDED
THAT the Landlord or the person exercising the foregoing rights shall exercise such rights in accordance with the principles of good estate management. 

Part IV 
 Easements, rights and privileges

  

	1.	 The full right for the Tenant, its servants, agents or licensees to use the Common Areas or any part thereof for all proper purposes in connection with the
use and enjoyment of the Premises and the Car Spaces PROVIDED ALWAYS THAT at any time during the Term or any extension thereof the Landlord shall have full right and liberty in its absolute discretion to alter, stop up or block such Common
Areas or any part or parts thereof, but not preventing the access to the Premises. 

  
 35 

	2.	 The right for the Tenant to use six (6) car spaces in the Basement in such positions as are allocated to the Tenant from time to time with reasonable
prior notice (which shall mean two weeks prior written notice for the avoidance of doubt), the initial allocation being spaces numbered 40,44,45,46,47 and 48 (Basement -1) shown inlined in red on Plan No. 1 annexed hereto.

  

	3.	 The free passage and running of utilities (subject to temporary interruption for repair, maintenance, renewal or replacement) to and from the Premises
through the Conduits which are now laid or (throughout the Term (or any extension or renewal thereof)) shall be laid in, under or through other parts of the Building so far as any of the same are necessary for the reasonable use and enjoyment of the
Premises. 

  

	4.	 The right of way for emergency purposes only over those parts of the Common Areas coloured blue on the Plans annexed hereto. 

 

	5.	 The right of way in the event of emergency only over that part of Block A shown shaded yellow on Plan 3 annexed hereto. 

 

	6.	 The right to use the existing bathrooms or toilet facilities and the existing lobby area on the first floor of the Building in common with any other
occupational tenant located on the first floor of the Building. 

  

	7.	 Subject to: 

  

	 	(a)	 The prior written consent of the Landlord and the Landlord’s prior approval of the size and location of any satellite dish equipment;

  

	 	(b)	 The Tenant paying all costs properly incurred by the Landlord in considering any application for such consent, including reasonable costs for professional
advice in reviewing the application; 

  

	 	(c)	 There being adequate and suitable space available on the roof of the Building at the time the Tenant makes an application for the Landlord’s consent;

  

	 	(d)	 The satellite dish equipment proposed to be installed by the Tenant having weight loading within acceptable limits; 

The right for the Tenant at the Tenant’s own expense to install and maintain on the roof of the Building satellite dish equipment
of a type acceptable to the Landlord and reasonably necessary for the Tenant’s use and enjoyment of the Premises, further subject to the Tenant complying with all requirements of the Landlord. 

 

	8.	 Subject to: 

  

	 	(a)	 The prior written consent of the Landlord and the Landlord’s prior approval of the size and location of any such HVAC condensers; 

  
 36 

	 	(b)	 The Tenant paying all costs properly incurred by the Landlord in considering any application for such consent, including reasonable costs for professional
advice in reviewing the application; 

  

	 	(c)	 There being adequate and suitable space available in the Basement on the wall beside the Car Spaces at the time the Tenant makes an application for
Landlord’s consent; 

  

	 	(d)	 The HVAC condensers proposed to be installed by the Tenant having weight loading within acceptable limits; 

The right for the Tenant at the Tenant’s own expense to install and maintain in the Basement one HVAC condenser of a type
acceptable to the Landlord and necessary for the Tenant’s use and enjoyment of the Premises and the Car Spaces on the wall beside each (where possible and practicable) of the Car Spaces , further subject to the Tenant complying with all
requirements of the Landlord. 

  
 37 

 Schedule 2 

Part I 
 First Service Charge 

 

	1.	 The Tenant shall pay the Tenant’s Proportion of the First Service Charge on the days and in the manner and otherwise in accordance with the provisions
hereinafter contained; 

  

	2.	 The amount of the First Service Charge shall be ascertained and certified by a certificate (hereinafter called “the certificate”) signed by the
Landlord’s auditors or accountants (at the discretion of the Landlord) acting as experts and not as arbitrators annually and so soon after the end of the Landlord’s financial year as may be practicable and shall relate to such year in
manner hereinafter mentioned; 

  

	3.	 The expression “the Landlord’s financial year” shall mean the period from the 1st day of January in each year to the 31st day of December of
that same year or such other annual period as the Landlord may at its discretion from time to time determine as being that in which the accounts of the Landlord either generally or relating to the Building shall be made up; 

 

	4.	 A copy of the certificate for each such financial year shall be supplied by the Landlord to the Tenant on written request and without charge to the Tenant;

  

	5.	 The certificate shall contain a summary of the Landlord’s said costs and expenses incurred by the Landlord during the Landlord’s financial year to
which it relates together with a summary of the relevant details and figures forming the basis of the First Service Charge and the certificate (or a copy thereof duly certified by the person by whom the same was given) shall be conclusive evidence
for the purposes hereof of the matters which it purports to certify save in circumstances of manifest error; 

  

	6.	 The expression “the costs and expenses incurred by the Landlord” as hereinbefore used shall be deemed to include not only those costs and expenses
hereinbefore described which have been actually disbursed incurred or made by the Landlord during the year in question but also such reasonable part of all such costs and expenses hereinbefore described which are of a periodically recurring nature
(whether recurring by regular or irregular periods) whenever disbursed incurred or made and whether prior to the commencement of the Term or otherwise including a sum or sums of money by way of reasonable provision for anticipated expenditure in
respect thereof as the Landlord or its auditors or accountants (as the case may be) may in their discretion allocate to the year in question as being fair and reasonable in the circumstance; 

 

	7.	 The Tenant shall with every quarterly payment of rent reserved hereunder pay to the Landlord such sum in advance and on account of the First Service Charge
as the Landlord or its auditors or accountants (as the case may be) shall specify at their reasonable discretion to be a fair and reasonable interim payment. 

 

	8.	 As soon as practicable after the signature of the certificate the Landlord shall furnish to the Tenant an account of the First Service Charge payable by the
Tenant for the year in question due credit being given therein for all interim payments made by the Tenant in respect of the said year and upon the furnishing of such account showing such adjustment

  
 38 

	 	 
as may be appropriate there shall be paid by the Tenant to the Landlord the amount of the First Service Charge as aforesaid or any balance found payable or there shall be allowed by the Landlord
to the Tenant any amount which may have been overpaid by the Tenant by way of interim payment as the case may require; 

  

	9.	 It is hereby agreed and declared that nothing in this Clause or these presents contained shall disable the Landlord from maintaining an action against the
Tenant in respect of non-payment of any such interim payment as aforesaid notwithstanding that the certificate had not been signed at the time of the proceedings. 

 

	10.	 It is hereby agreed and acknowledged that the First Service Charge payable by the Tenant hereunder shall include (meaning that the Reception Rent and Gym
Rent shall be added to any other costs and expenses) the Tenant’s Proportion of the Reception Rent and the Gym Rent, such rents to be calculated in accordance with Clause 11 of this Part I Schedule 2. 

 

	11.	 From the date hereof until 31 July 2015: 

  

	 	(i)	 the Reception Rent shall be calculated at a rate of €50.00(fifty euro) per square foot; and

  

	 	(ii)	 the Gym Rent shall be calculated at a rate of €25.00 (twenty five euro) per square foot;

 and thereafter each rent shall be adjusted on 1 August 2015 and on 1 August of every fifth year
thereafter (each an “Additional Rent Review Date”). From each Additional Rent Review Date the Reception Rent and the Gym Rent payable shall be an amount equal to the Reception Rent and the Gym Rent each adjusted by reference to the
Society of Chartered Surveyors / Investment Property Databank Office Rental Value Index (latest issue) (or in the event that such index no longer exists, by reference to the change in the cost of living as recorded by the Consumer Price Index), and
by increasing or decreasing the Reception Rent and the Gym Rent payable on the day immediately preceding each Additional Rent Review Date in proportion to the rise or fall in the respective index figures between the previous Additional Rent Review
Date and the current Additional Rent Review Date. From each Additional Rent Review Date until the next such review date the Tenant’s Proportion of the First Service Charge payable hereunder shall include the Tenant’s Proportion of the
Reception Rent and the Gym Rent so adjusted. 
  

	12.	 Immediately upon receipt of each payment of the Tenant’s Proportion of the First Service Charge the Landlord may deduct therefrom and pay to itself for
the Landlord’s own use and benefit and free from any claims of the Tenant that part of the said payment comprising the Tenant’s Proportion of the Reception Rent and the Gym Rent. 

 

	13.	 The inclusion of any of the Services in this Schedule shall not imply an obligation on the part of the Landlord or the Superior Landlord to provide such
Service. 

 PROVIDED ALWAYS and notwithstanding anything herein contained it is agreed and declared that the provisions of sub-clause (8) of this Clause shall continue to apply notwithstanding the expiration or sooner determination of the term hereby granted but only in respect of the period down to such expiration or sooner
determination of the Term; and 

  
 39 

 PROVIDED ALWAYS that the Landlord shall have full discretion acting in accordance with good estate
management to determine whether any cost or expense should form part of the First Service Charge or the Second Service Charge. 

  
 40 

 Part II 

(Services) 
  

	1.	 Repairing, renewing, replacing, maintaining, decorating and (where appropriate) cleaning, washing down, lighting, heating, servicing and (as and where
necessary) renewing the Common Areas and, without prejudice to the generality of the foregoing, the lobby and toilet facilities on the first floor of the Building. 

 

	2.	 Maintaining and, when necessary, replacing carpets, furnishings and equipment in the Common Areas as the Landlord may reasonably determine and, without
prejudice to the generality of the foregoing, the lobby and toilet facilities on the first floor of the Building. 

  

	3.	 Maintaining, repairing, operating, inspecting, servicing, overhauling, cleaning, lighting and (as and where necessary) renewing or replacing the air
conditioning plant and equipment (if any) in the Building, and all plant machinery, apparatus and equipment within the Common Areas from time to time and , without prejudice to the generality of the foregoing, the lobby and toilet facilities on the
first floor of the Building. 

  

	4.	 Maintaining, repairing, renewing, operating, inspecting, servicing, overhauling, cleaning and (as and where necessary) renewing or replacing all security and
emergency systems for the Building. 

  

	5.	 Providing and maintaining and renewing name boards and signs in the main entrance hall Reception and any other parts of the Building and all directional
signs and fire regulation notices and any flags, flag poles and television and radio aerials. 

  

	6.	 Providing and maintaining any dustbins or receptacles for refuse for the Building and the cost of collecting, storing and disposing of refuse.

  

	7.	 The provision, maintenance, replacement, planting and cultivation of all landscaping and floral and artistic displays in the Common Areas.

  
 41 

	8.	 Providing heating and cooling to the Premises in accordance with the following specification during the hours of 6.00am to 7.00pm Monday to Friday or such
further hours which the Landlord may deem appropriate acting reasonably and such other times as the Tenant may request (at the Tenant’s cost) PROVIDED ALWAYS that the Landlord shall maintain heating and cooling to the Premises within 10%
(Ten Per Cent) of the following parameters for chilled water, LPHW heating and ventilation as set out in this clause 8 of Part II of Schedule 2 (the “Parameters”), throughout the Term and rebalance affected systems or circuits, as
appropriate, in the event that chilled water and LPHW heating and ventilation fall outside those Parameters: 

 Chilled Water
Design Parameters: 
  

									
	 Floor
		CHW Flowrate		Flow Temperature		Return Temperature		 Calculated

KW Load

	
First Floor Area 1
		4.1 l/s		6 deg C		11 deg C		86.2 kW
	 		 		 		 		 

 LPHW Heating Design Parameters: 
  

									
	 Floor
		LPHW Flowrate		Flow Temperature		Return Temperature		 Calculated KW

Load

	
First Floor Area 1
		2.04 l/s		82 deg C		71 deg C		94.25 kW
	 		 		 		 		 

 Ventilation Design Parameters: 
  

									
	 Floor
		 Supply Air

Volume Flowrate
		 Supply Air Temperature.

(Summer)
		 Supply Air

Temperature
 (Winter)
		 Return Air

Volume
 Flowrate

	
First Floor Area 1
		2.0 m3/s		18 deg C		18 deg C		2.0 m3/s
	 		 		 		 		 

 and providing heating and cooling to the Common Areas to the specification reflected in the mechanical
and electrical specification set out in the Schedule 4 hereto to such temperatures as the Landlord may from time to time consider reasonably adequate between the hours of 7.00 am and 7.00 pm, Monday to Friday or such other hours which the Landlord
may deem appropriate acting reasonably and for such periods of the year as the Landlord shall reasonably deem desirable. 
  

	9.	 Any other services relating to the Common Areas or any part thereof which the Landlord shall provide from time to time if, in its opinion such service is
desirable or necessary in the interests of good estate management for the maintenance, upkeep or cleanliness of the Common Areas or for the benefit of all of the occupiers of the Building or otherwise in accordance with the principles of good estate
management. 

  

	10.	 Providing a staffed reception in the Reception between the hours of 07:00 to 19:00 Monday to Friday excluding public holidays. 

 

	11.	 Providing security personnel in the Building between the hours of 07:00 to 19:00 Monday to Friday excluding public holidays. 

  
 42 

 Part III 

(Expenditure) 
  

	1.	 The cost of management (including the collection of service charge) and of employing management agents, and accountants, auditors and surveyors in connection
with surveying and accounting functions or the provision of services to the Common Areas. 

  

	2.	 The cost of employing (whether by the Landlord or any managing agents) such staff as the Landlord may in its absolute discretion consider appropriate for the
performance of the services including reception and security personnel and all other expenditure ancillary to the employment of such persons including: 

  

	 	(i)	 salaries, wages, insurances, pensions and pension contributions and other statutory contributions or levies; 

 

	 	(ii)	 the provision of appropriate working clothing; 

  

	 	(iii)	 the provision of appropriate vehicles, tools, equipment and apparatus for the proper performance of the services 

 

	3.	 All rates, taxes, assessments, duties, charges, impositions and outgoings whatsoever whether parliamentary, local or of any other description which may be
assessed, charged, imposed or payable on or in respect of the whole or any part of the Common Areas. 

  

	4.	 The cost of the supply of electricity, gas, oil and other fuel for the provision of the services and the cost of any electricity generating, transforming,
monitoring, metering and distribution plant apparatus and equipment in or serving the Common Areas. 

  

	5.	 Interest and fees in respect of money borrowed to finance the provision of the services and the cost referred to in this part of this Schedule or any of
them. 

  

	6.	 The cost to the Landlord of abating any nuisance in respect of the Common Areas or any part of it. 

 

	7.	 Any legal costs and expenses incurred in the course of managing, operating and maintaining the Building and enforcing any covenants, conditions and
regulations with respect thereto or complying with or otherwise taking action on any notice or orders in respect of the Common Areas and all legal and other costs and expenses incurred by the Landlord in enforcing the Landlord’s contractual
rights pursuant to any collateral warranties issued to it in respect of any defect or disrepair in the Common Areas against any building contractor, sub-contractors, architect, mechanical and electrical engineer and civil and structural engineer
involved in the design and construction of the Building. 

  

	8.	 Any VAT (or any tax of a similar nature which may be substituted for or levied in addition to it) incurred by the Landlord on the cost referred to in this
part of this Schedule or any of them save to the extent that such VAT (or other tax) is recoverable by the Landlord pursuant to the provisions of the VAT Act as amended from time to time. 

 

	9.	 Such sums as the Landlord shall, in its reasonable discretion, consider desirable to set aside from time to time for the purpose of providing for
periodically recurring items of expenditure, whether recurring at regular or irregular intervals (such sums to be held in a separate interest bearing deposit account); 

  
 43 

	10.	 The Reception Rent; 

  

	11.	 The Gym Rent; 

  

	12.	 All other costs incurred in connection with provision of the services. 

  
 44 

 Schedule 3 

Rent Review Provisions 
  

	1	 Interpretation 

In this Schedule the following expressions shall have the following meanings respectively: 

“Review Date” shall mean the              day of
                    2019 and on the day of
                             every fifth year thereafter any date so stipulated by virtue of paragraph 2.6 of
this Schedule. 
  

	1.1	 “Review Rent” shall mean the full yearly open market rent without any deduction whatsoever at which the Premises and the six (6) Car
Spaces might reasonably be expected to be let at the relevant Review Date in the open market without a fine or premium and with vacant possession thereof by a willing landlord to a willing tenant for a term of fifteen (15) years computed from
the relevant Review Date with an entitlement for the Tenant to terminate the said lease as of the tenth (10th) anniversary of the relevant Review Date and otherwise on the same terms and
conditions in all other respects as this present Lease (save as to the amount of rent first reserved under this Lease but including the provisions for rent review) and upon the assumptions that: 

 

	 	(i)	 the Premises are provided to the Tenant as per the Landlord’s Specification (at the Landlord’s expense) and are fitted-out to a high quality
standard and ready for immediate use and occupation. 

  

	 	(ii)	 in case the building of which the Premises form part or any part of it has been destroyed or damaged it has been fully restored. 

 

	 	(iii)	 all the obligations on the part of the Tenant and the Landlord contained in this Lease have been fully complied with. 

 

	 	(iv)	 no work has been carried out to the Premises which would diminish its rental value other than works to comply with statutory requirements.

  

	 	(v)	 the Premises (excluding Car Spaces) comprise 10,266 square feet (ten thousand two hundred and sixty six square feet) of net lettable office space provided
that, for the avoidance of doubt, the Premises has beneficial use of six (6) Car Spaces. 

 and there being
disregarded: 
  

	 	(1)	 any effect on rent of the fact that the Tenant or any underlessee has been in occupation of the Premises and any goodwill attached to the Premises by reason
of the carrying on thereat of the business of the Tenant or any underlessee; 

  

	 	(2)	 any effect on rent of any alterations to the Premises or any part thereof carried out by the Tenant or any underlessee with the consent of the Landlord at
the Tenant’s or underlessee’s own expense (otherwise than in pursuance of any obligation to the Landlord) and carried out during the Term or pursuant to any Agreement for Lease; 

  
 45 

	 	(3)	 any rent free concession reduced or abated rent or inducement of any kind which would or might be given to an incoming tenant on the grant of a lease of the
Premises at the relevant Review Date to the intent that there shall be no reduction in the Review Rent to reflect such rent free concession reduced or abated rent or inducement or to compensate the Tenant for any absence of same;

  

	1.2	 “Surveyor” means an independent Chartered Surveyor experienced in the letting of office premises in the area in which the Premises are
located. 

  

	2	 Review Rent 

The yearly rent first reserved and payable from each Review Date until the next Review Date (or, in the case of the period commencing on
the last Review Date during the Term, until expiry of the Term) shall be the Review Rent. 
  

	2.1	 Agreement or determination of the reviewed rent 

If the Landlord and the Tenant shall not have agreed the Review Rent by the Review Date (or such extended period as may be agreed
between the Landlord and the Tenant) the Landlord or the Tenant may by notice in writing to the the other party require the Review Rent to be determined by the Surveyor who shall be appointed forthwith by the Landlord and the Tenant or (in default
of agreement at any time about his appointment) as nominated by the President for the time being of the Society of Chartered Surveyors on the application of either the Landlord or the Tenant. 

 

	2.2	 Functions of Surveyor 

  

	 	2.2.1	 Unless the Landlord elects that the Surveyor shall act as an expert he shall act as an Arbitrator and the arbitration shall be conducted in accordance with
the Arbitration Act. 

  

	 	2.2.2	 If the Surveyor is appointed as an expert he shall be required to give notice to the Landlord and the Tenant inviting each of them to submit to him within
such time limits as he shall stipulate a proposal for the Review Rent and affording each party the opportunity to give in writing or otherwise a statement of reasons in support of its proposal and to make submissions in respect of each other’s
statement of reasons but the Surveyor shall not be bound thereby and shall make the determination in accordance with his own judgement. 

  

	 	2.2.3	 If the Surveyor shall fail to determine the Review Rent within four months of his appointment or nomination or if he shall relinquish his appointment or die
or if it shall become apparent that for any reason he will be unable or unfit to complete his duties hereunder a new Surveyor shall be appointed or nominated in his place in accordance with sub-clause 2.1
above. 

  

	2.3	 Fees of Surveyor 

The fees and expenses of the Surveyor including the costs of his nomination shall be in the award of the Surveyor (but this shall not
preclude the Surveyor from notifying both parties of his total fees and expenses notwithstanding the non-publication at the time of his 

  
 46 

 
award). Without prejudice to the foregoing, both the Landlord and the Tenant shall be entitled to pay the entire fees and expenses due to the Surveyor and thereafter recover as a simple contract
debt the amount (if any) due from the party who failed or refused to pay same. 
  

	2.4	 Interim payments pending determination 

If upon any such review the amount of the Review Rent shall not be ascertained or determined prior to the Review Date the Tenant shall
continue to pay the rent payable hereunder immediately prior to the relevant Review Date (the “Current Rent”) until the Gale Day next following the ascertainment or determination of the Review Rent whereupon there shall be due as a
debt: (i) payable on demand by the Tenant to the Landlord (if the Review Rent is higher than the Current Rent) a sum equal to the amount by which the Review Rent for the period since the Review Date exceeds the Current Rent for that period and
in addition shall pay interest on said sums at the Base Rate from time to time from the Review Date until the date of actual payment; or (ii) by the Landlord to the Tenant (if the Review Rent is lower than the Current Rent payable before the
Review Date) a sum equal to the amount by which the Current Rent for the period since the Review Date exceeds the Review Rent for that period and in addition shall pay interest on the said sums at the Base Rate from time to time from the Review Date
until the date of actual payment. 
  

	2.5	 Rent review memorandum 

If upon any such review as aforesaid it shall be agreed or determined that the Review Rent is greater or less than the Current Rent the
Landlord and the Tenant shall as soon as practicable after such determination or expiration complete and sign a written memorandum recording the Review Rent payable from the Review Date payable and the Tenant shall pay the Stamp Duty payable on such
Memorandum. 
  

	2.6	 Rent restrictions 

In the event of either the Landlord or the Tenant being prevented or prohibited in whole or in part from determining the Review Rent by
reason of any Legislation Statute Government Order or Decree or Notice then the date at which the review would otherwise have taken effect shall be deemed to be extended to permit and require such review to take place on the first date thereafter
upon which Review Rent may be determined and if there shall be a partial prevention only there shall be a further review on the first date or dates as aforesaid. 

  
 47 

 Schedule 4 

Landlord’s Specification 

  
 48 

 Schedule 5 

Guarantee 
  

	1.	 Guarantee 

 The
Guarantor hereby covenants with the landlord: 
  

	1.1	 as a primary obligation that the Tenant or the Guarantor shall at all times during the Term (including any continuation or renewal of this Lease) duly
perform and observe all the covenants on the part of the Tenant contained in this Lease, including the payment of the rents and all other sums payable under this Lease in the manner and at the times herein specified and the Guarantor hereby
indemnifies the Landlord against all claims demands losses damages liability costs fees and expenses whatsoever sustained by the Landlord by reason of or arising in any way directly or indirectly out of any default by the Tenant in the performance
and observance of any of its obligations or the payment of any rent and other sums arising before or after the expiration or termination of this Lease. 

  

	1.2	 that the Guarantor is jointly and severally liable with the Tenant (whether before or after any disclaimer by a liquidator, official assignee or trustee in
bankruptcy or other persons administering the assets of the Tenant or whether before or after any repudiation by an examiner or other persons administering the assets of the Tenant) for the fulfilment of all the obligations of the Tenant under this
Lease and agrees that the Landlord in the enforcement of its rights hereunder, may proceed against the Guarantor as if the Guarantor was named as the Tenant in this Lease; 

 

	1.3	 that the Guarantor shall not claim in any liquidation, bankruptcy, examinership, composition or arrangement of the Tenant in competition with the Landlord
and shall remit to the Landlord the proceeds of all judgements and all distributions it may receive from any liquidator, examiner, official assignee, trustee in bankruptcy or supervisor of the Tenant and shall hold for the benefit of the Landlord
all security and rights the Guarantor may have over assets of the Tenant whilst any liabilities of the Tenant or the Guarantor to the Landlord remain outstanding; 

 

	1.4	 that the Guarantor shall: 

  

	 	1.4.1	 if a liquidator, official assignee or trustee in bankruptcy or examiner shall disclaim, surrender or repudiate this Lease; or 

 

	 	1.4.2	 if this Lease shall be forfeited; or 

  

	 	1.4.3	 if the Tenant shall cease to exist, 

on notice in writing given to the Guarantor by the Landlord within twelve (12) months after such disclaimer or other event accept
from and execute and deliver to the Landlord a new lease of the Premises subject to and with the benefit of this Lease (if the same shall still be deemed to be extant at such time) for a term commencing on the date of the disclaimer or other event
and continuing for the residue then remaining unexpired of the Term, such new lease to be at the cost of the Guarantor and to be at the same rents (the 

  
 49 

 
initial annual rent being the same as that payable under this Lease at the time of any disclaimer or at the time of the happening of any event referred to above) and subject to the same covenants
conditions and provisions as are contained in this Lease; 
  

	1.5	 if following the occurrence of the events referred to in paragraph 1.4 the Landlord shall not require the Guarantor to take a new lease, the Guarantor shall
nevertheless upon demand pay to the Landlord a sum equal to the rents and other sums that would have been payable under this Lease but for the disclaimer, forfeiture or other event in respect of the period from and including the date of such
disclaimer, forfeiture or other event until the expiration of twelve (12) months therefrom or until the Landlord shall have granted a lease of the Premises to a third party (whichever shall first occur). 

 

	2.	 Waiver by guarantor 

The Guarantor hereby waives any right to require the Landlord to proceed against the Tenant or to pursue any other remedy whatsoever
which may be available to the Landlord before proceeding against the Guarantor. 
  

	3.	 Postponement of participation by guarantor in security 

The Guarantor shall not be entitled to participate in any security held by the Landlord in respect of the Tenant’s obligations to
the Landlord under this Lease or to stand in the place of the Landlord in respect of any such security until all the obligations of the Tenant or the Guarantor to the Landlord under this Lease have been performed or discharged. 

 

	4.	 No release of guarantor 

  

	4.1	 None of the following, or any combination thereof, shall release, determine, discharge or in any way lessen or affect the liability of the Guarantor as
principal debtor under this Lease or otherwise prejudice or affect the right of the Landlord to recover from the Guarantor to the full extent of this guarantee: 

 

	4.2	 any neglect, delay or forbearance of the Landlord in endeavouring to obtain payment of the rents or any part or parts thereof and / or the amounts required
to be paid by the Tenant or in enforcing the performance or observance of any of the obligations of the Tenant under this Lease; 

  

	4.3	 any refusal by the Landlord to accept rent tendered by or on behalf of the Tenant at a time when the Landlord was entitled (or would after the service of a
notice under Section 14 of the 1881 Act have been entitled) to re-enter the Premises; 

  

	4.4	 any extension of time given by the Landlord to the Tenant; 

  

	4.5	 any variation of the terms of this Lease (including any reviews of the rent payable under this Lease) or the transfer of the Landlord’s reversion or the
assignment of this Lease; 

  

	4.6	 any change in the constitution, structure or powers of either the Tenant, the Guarantor or the Landlord or the liquidation, receivership, examinership,
administration or bankruptcy (as the case may be) of either the Tenant or the Guarantor; 

  
 50 

	4.7	 any legal limitation, or any immunity, disability or incapacity of the Tenant (whether or not known to the Landlord) or the fact that any dealings with the
Landlord by the Tenant may be outside or in excess of the powers of the Tenant; 

  

	4.8	 any other act, omission, matter or thing whatsoever whereby, but for this provision, the Guarantor would be exonerated either wholly or in part (other than a
release under seal given by the Landlord). 

  

	5.	 Benefit of guarantee 

This guarantee shall ensure for the benefit of the successors and assigns of the Landlord under this Lease without the necessity for any
assignment thereof. 
  

	6.	 Joint and several 

Where the Guarantor consists of two or more persons the covenants contained in this Lease shall be deemed to be made by such persons
jointly and severally. 

  
 51 

 Schedule 6 

Part I 
 Second Service Charge 

 

	1.	 The Tenant shall pay the Tenant’s Share of the Second Service Charge on the days and in the manner and otherwise in accordance with the provisions
hereinafter contained; 

  

	2.	 The amount of the Second Service Charge shall be ascertained and certified by a certificate (hereinafter called “the certificate”) signed by the
Landlord’s auditors or accountants (at the discretion of the Landlord) acting as experts and not as arbitrators annually and so soon after the end of the Landlord’s financial year as may be practicable and shall relate to such year in
manner hereinafter mentioned; 

  

	3.	 The expression “the Landlord’s financial year” shall mean the period from the 1st day of January in each year to the 31st day of December of
that same year or such other annual period as the Landlord may at its discretion from time to time determine as being that in which the accounts of the Landlord either generally or relating to the Building shall be made up; 

 

	4.	 A copy of the certificate for each such financial year shall be supplied by the Landlord to the Tenant on written request and without charge to the Tenant;

  

	5.	 The certificate shall contain a summary of the Landlord’s said costs and expenses incurred by the Landlord during the Landlord’s financial year to
which it relates together with a summary of the relevant details and figures forming the basis of the Second Service Charge and the certificate (or a copy thereof duly certified by the person by whom the same was given) shall be conclusive evidence
for the purposes hereof of the matters which it purports to certify save in circumstances of manifest error; 

  

	6.	 The expression “the costs and expenses incurred by the Landlord” as hereinbefore used shall be deemed to include not only those costs and expenses
hereinbefore described which have been actually disbursed incurred or made by the Landlord during the year in question but also such reasonable part of all such costs and expenses hereinbefore described which are of a periodically recurring nature
(whether recurring by regular or irregular periods) whenever disbursed incurred or made and whether prior to the commencement of the Term or otherwise including a sum or sums of money by way of reasonable provision for anticipated expenditure in
respect thereof as the Landlord or its auditors or accountants (as the case may be) may in their discretion allocate to the year in question as being fair and reasonable in the circumstance; 

 

	7.	 The Tenant shall with every quarterly payment of rent reserved hereunder pay to the Landlord such sum in advance and on account of the Second Service Charge
as the Landlord or its auditors or accountants (as the case may be) shall specify at their reasonable discretion to be a fair and reasonable interim payment. 

 

	8.	 As soon as practicable after the signature of the certificate the Landlord shall furnish to the Tenant an account of the Second Service Charge payable by the
Tenant for the year in question due credit being given therein for all interim payments made by the Tenant in respect of the said year and upon the furnishing of such account showing such adjustment

  
 52 

	 	 
as may be appropriate there shall be paid by the Tenant to the Landlord the amount of the Second Service Charge as aforesaid or any balance found payable or there shall be allowed by the Landlord
to the Tenant any amount which may have been overpaid by the Tenant by way of interim payment as the case may require; 

  

	9.	 It is hereby agreed and declared that nothing in this Clause or these presents contained shall disable the Landlord from maintaining an action against the
Tenant in respect of non-payment of any such interim payment as aforesaid notwithstanding that the certificate had not been signed at the time of the proceedings. 

 

	10.	 Immediately upon receipt of each payment of the Tenant’s Proportion of the Second Service Charge the Landlord may deduct therefrom and pay to itself for
the Landlord’s own use and benefit. 

  

	11.	 The inclusion of any of the Services in this Schedule shall not imply an obligation on the part of the Landlord or the Superior Landlord to provide such
Service. 

 PROVIDED ALWAYS and notwithstanding anything herein contained it is agreed and declared that the provisions of sub-clause (8) of this Clause shall continue to apply notwithstanding the expiration or sooner determination of the term hereby granted but only in respect of the period down to such expiration or sooner
determination of the Term; and 
 PROVIDED ALWAYS that the Landlord shall have full discretion acting in accordance with good estate management
to determine whether any cost or expense should form part of the First Service Charge or the Second Service Charge. 

  
 53 

 Part II 

(Services) 
  

	1.	 Repairing, renewing, replacing, maintaining, decorating and (where appropriate) cleaning, washing down, lighting, heating, servicing and (as and where
necessary) renewing the First Floor Common Areas and, without prejudice to the generality of the foregoing, the lobby, fire alarm panel and toilet facilities on the first floor of the Building. 

 

	2.	 Maintaining and, when necessary, replacing carpets, furnishings, consumables and equipment in the First Floor Common Areas as the Landlord may in its
absolute discretion determine and, without prejudice to the generality of the foregoing, the lobby, fire alarm panel and toilet facilities on the first floor of the Building. 

 

	3.	 Maintaining, repairing, operating, inspecting, servicing, overhauling, cleaning, lighting and (as and where necessary) renewing or replacing the air
conditioning plant and equipment (if any) in the First Floor Floor Common Areas and all plant machinery, apparatus and equipment within the First Floor Common Areas from time to time and , without prejudice to the generality of the foregoing, the
lobby, fire alarm panel and toilet facilities on the first floor of the Building. 

  

	4.	 Maintaining, repairing, renewing, operating, inspecting, servicing, overhauling, cleaning and (as and where necessary) renewing or replacing all security and
emergency systems for the First Floor Common Areas. 

  

	5.	 Providing and maintaining any dustbins or receptacles for refuse for the Building and the cost of collecting, storing and disposing of refuse.

  

	6.	 The provision, maintenance, replacement, planting and cultivation of all landscaping and floral and artistic displays in the First Floor Common Areas.

  

	7.	 Providing heating and cooling to the First Floor Common Areas to the specification reflected in the mechanical and electrical specification set out in the
Schedule 4 hereto to such temperatures as the Landlord may from time to time consider reasonably adequate between the hours of 7.00 am and 7.00 pm, Monday to Friday or such other hours which the Landlord may deem appropriate acting reasonably and
for such periods of the year as the Landlord shall reasonably deem desirable. 

  

	8.	 Any other services relating to the First Floor Common Areas or any part thereof which the Landlord shall provide from time to time if, in its opinion such
service is desirable or necessary in the interests of good estate management for the maintenance, upkeep or cleanliness of the First Floor Common Areas or for the benefit of all of the occupiers of the first floor or otherwise in accordance with the
principles of good estate management. 

  

	9.	 Providing and maintaining name boards and signs in the entrance hall and any other parts of the first floor of the Building and all directional signs and
fire regulation notices and any flags, flag poles and television and radio aerials. 

  
 54 

 Part III 

(Expenditure) 
  

	1.	 The cost of management (including the collection of the Second Service Charge) and of employing management agents, and accountants, auditors and surveyors in
connection with surveying and accounting functions or the provision of services to the First Floor Common Areas 

  

	2.	 The cost of employing (whether by the Landlord or any managing agents) such staff as the Landlord may in its absolute discretion consider appropriate for the
performance of the services referred to in this Schedule including reception and security personnel and all other expenditure ancillary to the employment of such persons including: 

 

	 	(i)	 salaries, wages, insurances, pensions and pension contributions and other statutory contributions or levies; 

 

	 	(ii)	 the provision of appropriate working clothing; 

  

	 	(iii)	 the provision of appropriate vehicles, tools, equipment and apparatus for the proper performance of the services referred to in this Schedule

  

	3.	 All rates, taxes, assessments, duties, charges, impositions and outgoings whatsoever whether parliamentary, local or of any other description which may be
assessed, charged, imposed or payable on or in respect of the whole or any part of the First Floor Common Areas. 

  

	4.	 The cost of the supply of electricity, gas, oil and other fuel for the provision of the services referred to in this Schedule and the cost of any electricity
generating, transforming, monitoring, metering and distribution plant apparatus and equipment in or serving the First Floor Common Areas. 

  

	5.	 Interest and fees in respect of money borrowed to finance the provision of the services referred to in this Schedule and the cost referred to in this part of
this Schedule or any of them. 

  

	6.	 The cost to the Landlord of abating any nuisance in respect of the First Floor Common Areas or any part of it in so far as the same is not the liability of
any one tenant or occupier of the Building. 

  

	7.	 Any legal costs and expenses incurred in the course of managing, operating and maintaining the First Floor Common Areas and enforcing any covenants,
conditions and regulations with respect thereto or complying with or otherwise taking action on any notice or orders in respect of the First Floor Common Areas and all legal and other costs and expenses incurred by the Landlord in enforcing the
Landlord’s contractual rights pursuant to any collateral warranties issued to it in respect of any defect or disrepair in the First Floor Common Areas against any building contractor, sub-contractors, architect, mechanical and electrical
engineer and civil and structural engineer involved in the design and construction of the Building. 

  
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	8.	 Any VAT (or any tax of a similar nature which may be substituted for or levied in addition to it) incurred by the Landlord on the cost referred to in this
part of this Schedule or any of them save to the extent that such VAT (or other tax) is recoverable by the Landlord pursuant to the provisions of the VAT Act as amended from time to time. 

 

	9.	 Such sums as the Landlord shall, in its absolute discretion acting reasonably, consider desirable to set aside from time to time for the purpose of providing
for periodically recurring items of expenditure, whether recurring at regular or irregular intervals (such sums to be held in a separate interest bearing deposit account); 

 

	10.	 All other costs properly incurred in connection with provision of the services referred to in this Schedule. 

  
 56 

					
	 SIGNED AND DELIVERED
 as a
deed by JOHN RONAN
 in the presence of:
		 /s/  John Ronan
		

  
  
  

					
	 PRESENT when the Common Seal of
				
	 CASTLE COVE PROPERTY DEVELOPMENTS
				
	 LIMITED was affixed hereto as a deed
				
			 /s/  John Ronan
		
			 Director
		
			
			 /s/  Jodi Ronan
		
			 Director / Secretary
		

  
 57 

					
	 PRESENT when the Common Seal of

HORIZON PHARMA SERVICES LIMITED
 (THE
TENANT)
				
	 was affixed hereto as a deed:
				
			   /s/  Patrick Ashe
		
			 Director
		
			
			   /s/   David Kelly
		
			 Director / Secretary
		

  
  
  

					
	 PRESENT when the Common Seal of

HORIZON PHARMA PUBLIC LIMITED COMPANY
 (THE
GUARANTOR)
		
	 was affixed hereto as a deed:
				
			   /s/  Timothy P. Walbert
		
			 Director
		
			
			   /s/  Paul W. Hoelscher
		
			 Director / Secretary
		

  
 58EX-10.59

 Exhibit 10.59 

ASSET PURCHASE AGREEMENT 

This ASSET PURCHASE AGREEMENT (as amended from time to time, the “Agreement”), dated as of May 17, 2012 (the
“Agreement Date”), is made and entered into by and among Vidara Therapeutics International Limited, an Irish company (“Purchaser”), Vidara Therapeutics Holdings LLC, a Delaware limited liability company
(“Parent”), Vidara Therapeutics Research Limited, an Irish company (“Opco”) and InterMune, Inc., a Delaware corporation (“Seller”). Purchaser, Parent, Opco and Seller are sometimes collectively
referred to herein as the “Parties” and separately as a “Party.” 
 RECITALS 

WHEREAS, Seller is a biopharmaceutical company focused on developing and commercializing innovative therapies in pulmonology and hepatology;

 WHEREAS, Purchaser is a biopharmaceutical company focused on the development and commercialization of differentiated specialty products
to treat unmet medical needs; 
 WHEREAS, Seller has determined that the sale of certain products and product related intellectual property
rights at this time is consistent with its current business strategy; 
 WHEREAS, Purchaser has determined that the acquisition of those
certain products and product related intellectual property rights at this time is consistent with its current business strategy; 
 WHEREAS,
Purchaser is a wholly-owned subsidiary of Parent and Opco is a wholly-owned, indirect subsidiary of Purchaser; and 
 WHEREAS, Seller
desires to sell such products and product-related intellectual property rights to Purchaser, and Purchaser desires to purchase such products and product-related intellectual property rights from Seller, on the terms and subject to the conditions set
forth herein. 
 NOW, THEREFORE, in consideration of the promises, representations, warranties, covenants and agreements contained herein
and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Parties hereto, intending to be legally bound hereby, agree as follows: 

ARTICLE I 
 DEFINITIONS

 Section 1.1 Defined Terms. For the purposes of this Agreement, the following words and phrases shall have the
following meanings whether in the singular or the plural: 
 “AAA” shall have the meaning set forth in
Section 10.12(a). 
 “Acquisition Proposal” shall mean an indication of interest, offer or proposal to acquire
Seller’s right, title and interest in and to all or any substantial portion of the Purchased Assets in 

  
 1 

 
a single transaction or series of related transactions (other than the transactions provided for in this Agreement). 

“Additional Intellectual Property” shall have the meaning set forth in Section 8.15(c). 

“Affiliate” shall mean with respect to any Person, any other Person which controls, is controlled by, or is under common
control with such Person. For purposes of this definition, a Person shall be regarded as in control of another Person if it owns or controls, directly or indirectly, (i) in the case of corporate entities, direct or indirect ownership of at
least fifty percent (50%) of the stock or shares (or such lesser percentage which is the maximum allowed to be owned by a foreign corporation in a particular jurisdiction) entitled to vote for the election of directors or otherwise having the
power to vote on or direct the affairs of such Person; and (ii) in the case of non-corporate entities, direct or indirect ownership of at least fifty percent (50%) (or the maximum ownership interest permitted by law) of the equity interest
or the power to direct the management and policies of such non-corporate entities. 
 “Agreement” shall have the meaning
set forth in the first paragraph of this Agreement. 
 “Agreement Date” shall mean the date set forth in the first
paragraph of this Agreement. 
 “Allocation Schedule” shall have the meaning set forth in Section 2.8. 

“Alternate Seller Bank Account” shall have the meaning set forth in Section 2.1(b)(ii)(A). 

“Ancillary Agreements” shall mean the Assignment and Assumption Agreements, the Bills of Sale, the Domain Name Assignment
Agreement, the Patent Assignment Agreement and the Transition Services Agreement. 
 “Annual Period” shall mean a twelve
(12) month period measured from the Closing Date, or an anniversary of the Closing Date, to the next anniversary of the Closing Date. 

“Antitrust Regulations” shall mean the HSR Act and any other Applicable Laws or regulations relating to antitrust or
competition. 
 “Applicable Law” shall mean all applicable provisions of all statutes, Laws, rules, regulations,
administrative codes, ordinances, decrees, orders, decisions, guidance documents, injunctions, awards, judgments, and permits and licenses of or from Governmental Authorities relating to or governing the use or regulation of the subject item. 

“Assignment and Assumption Agreements” shall mean those certain assignment and assumption agreements in the form attached
hereto as Exhibit B. 
 “Assumed Contracts” shall mean (i) the Contracts identified on Schedule 1.1(d)
and (ii) any purchase orders for Product received by Seller or its Affiliates prior to the Closing Date, but not shipped prior to 11:59 p.m., PDT, on the day prior to the Closing Date. 

“Assumed Liabilities” shall mean the Liabilities set forth in Section 2.3. 

  
 2 

 “B-I Purchase Orders” shall mean (i) that certain Purchase Order No.
PO10395, dated as of May 2, 2012, submitted by Seller to Boehringer-Ingelheim and (ii) that certain Purchase Order No. PO10396, dated as of May 2, 2012, submitted by Seller to Boehringer-Ingelheim, both of which are appended hereto as
Exhibit F. 
 “B-I Supply Agreement” shall mean the Supply Agreement between Seller and Boehringer-Ingelheim dated
as of June 29, 2007, as amended and restated as of May 15, 2012, providing for the manufacture and supply of the Product, attached as part of Exhibit E. 

“Basket Amount” shall have the meaning set forth in Section 9.2(a). 

“Bills of Sale” shall mean those certain bills of sale in the forms attached hereto as Exhibit A. 

“Boehringer-Ingelheim” shall mean Boehringer Ingelheim Austria GmbH or its successor-in-interest Boehringer Ingelheim RCV
GmbH & Co KG. 
 “Business Day” shall mean a day, which is not a Saturday, a Sunday, or a statutory holiday in the
United States. 
 “Cap” shall have the meaning set forth in Section 9.2(c). 

“Chargebacks” shall mean chargebacks and similar payments to wholesalers and other distributors in connection with the
Product. 
 “Closing” shall have the meaning set forth in Section 2.5. 

“Closing Cash Payment” shall have the meaning set forth in Section 2.1(b)(i). 

“Closing Date” shall have the meaning set forth in Section 2.5. 

“Code” shall mean the United States Internal Revenue Code of 1986, as amended. 

“Commercial Rebates” shall mean rebates to commercial customers. 

“Competing Product” shall mean any product that is or is being developed to be a generic equivalent of, a generic formulation
of, biosimilar or interchangeable with the Product where “biosimilar” and “interchangeable” shall have the meaning ascribed to them under the Biosimilars Act 42 USC 262(i). 

“Confidentiality Agreement” shall have the meaning set forth in Section 10.1(a). 

“Confidential Information” shall mean Purchaser Confidential Information and Seller Confidential Information. 

“Consent” shall have the meaning set forth in Section 2.9. 

“Contract” shall mean any agreement, contract, lease, consensual obligation, promise, or undertaking (whether written or
oral), to which Seller or any of its Affiliates is a party (i) that 

  
 3 

 
relates solely or primarily to the Product, the Product Business, the Purchased Assets or the Assumed Liabilities, or (ii) that, to the extent related to the Product, is necessary for the
conduct of the Product Business as conducted by Seller. 
 “Controlled” shall mean, with respect to any of the Inventory,
any of the Product Intellectual Property and any of the Product Records, that is owned or licensed (as licensor or licensee) by Seller and/or any of its Affiliates, and in which Seller has the legal authority or right to grant, convey, transfer and
assign to Purchaser, all of Seller’s (and any of its Affiliates’) rights, titles and interests therein and thereto. 

“Copyright” shall mean U.S., international or foreign copyrights, including any and all Copyright Registrations and
Applications therefor, and all exclusive rights under all such copyrights, for, in and to, or otherwise based upon any and all documents, website content, data, artwork, advertising materials, product packaging, product labels, product packaging
inserts and product instructions. 
 “Copyright Registrations and Applications” shall mean U.S., international or foreign
copyright registrations, recordations and applications, and any and all renewals, extensions and reversions thereof, for which a registration or serial number may be, has been or will be assigned by the relevant Governmental Authority. 

“Dispute” shall have the meaning set forth in Section 10.12(a). 

“Domain Name Assignment Agreement” shall mean that certain domain name and webpages assignment agreement in the form attached
hereto as Exhibit G. 
 “Domain Names” shall mean any and all Internet domain names, websites and URLs, and any and
all applications and registrations therefor. 
 “Earnout” shall have the meaning set forth in
Section 2.1(b)(ii)(A). 
 “Encumbrance” shall mean claims, security interests, liens, pledges, charges,
escrows, options, proxies, rights of first refusal, preemptive rights, covenants not to sue, mortgages, hypothecations, assessments, prior assignments, reversionary rights, reversionary titles, reversionary interests, title retention agreements,
conditional sales agreements, indentures, deeds of trust, leases, levys or security agreements of any kind whatsoever, or any other agreements to give any of the foregoing in the future, imposed upon the subject property or item. 

“Environmental Law” shall mean any applicable Law relating directly or indirectly to (i) the protection of the
environment (including air, water vapor, surface water, groundwater, drinking water supply, surface or subsurface land), (ii) occupational health and safety or (iii) the exposure to, or the use, storage, recycling, treatment, generation,
transportation, processing, handling, labeling, recycling, release or disposal of, hazardous materials. 
 “Exchange Act”
shall have the meaning set forth in Section 3.13(a). 
 “Excluded Assets” shall mean all assets and properties
(other than the Purchased Assets) of Seller and its Affiliates, including without limitation the Excluded Data and Materials. 

  
 4 

 “Excluded Claim” shall mean any dispute, controversy or claim arising from or
related to (i) any of the representations, warranties, covenants, agreements and/or provisions set forth in Sections 3.10, 8.14 and/or 8.15 of this Agreement, and any inaccuracy or breach thereof, (ii) any of the
representations, warranties, covenants, agreements and/or provisions of this Agreement that relate to the Product Intellectual Property and any inaccuracy or breach thereof and (iii) any antitrust, anti-monopoly or competition law or
regulation, whether or not statutory. 
 “Excluded Data and Materials” shall mean all case report forms, data, reports,
publications, abstracts and other information, materials and patient samples generated by or for Seller or its Affiliates in the conduct of the clinical development of Interferon Gamma-1b for the treatment of patients with idiopathic pulmonary
fibrosis. 
 “Excluded Liabilities” shall have the meaning set forth in Section 2.4(a). 

“FDA” shall mean the United States Food and Drug Administration or any successor organization. 

“Financial Data” shall have the meaning set forth in Section 3.13(c). 

“GAAP” shall mean United States generally accepted accounting principles. 

“Genentech License” shall mean the License Agreement for Interferon Gamma between Connectics Corporation and Genentech, Inc.
dated as of May 5, 1998, as amended. 
 “Genentech Patents” shall mean the Patent Rights granted pursuant to the
Genentech License. 
 “Governmental Authority” shall mean the government of the applicable country in the Territory and any
state, province, municipality or other political subdivision thereof or therein, or any court, tribunal, judiciary body, agency, department, board, instrumentality, panel, dispute resolution agency, patent office, trademark office, copyright office
and any official authority or commission (including regulatory and administrative bodies) of any of the foregoing. 

“HIPAA” shall have the meaning set forth in Section 3.15(b). 

“HITECH” shall have the meaning set forth in Section 3.15(b). 

“HSR Act” shall have the meaning set forth in Section 8.1(b). 

“Indemnification Claim Notice” shall have the meaning set forth in Section 9.4. 

“Indemnified Party” shall mean the Seller Indemnified Parties or the Purchaser Indemnified Parties, as applicable, in
accordance with the terms of this Agreement. 
 “Indemnifying Party” shall mean the Purchaser, Parent or the Seller, as
applicable, in accordance with the terms of this Agreement. 

  
 5 

 “Intellectual Property” shall mean the Copyrights, Domain Names, Know-How,
Patent Rights, Trademarks and Trade Secrets. 
 “Interferon Gamma-1b” shall mean the amino acid sequence and description
set forth on Exhibit 1 to the Seller Disclosure Schedule. 
 “Inventory” shall mean the Product, and all active
pharmaceutical ingredients which are used solely or primarily in the production of the Product, that are owned or Controlled by Seller or its Affiliates on the Closing Date for Seller’s marketing and sale and which (i) are of a quality
usable and salable in the ordinary course of business and (ii) in the case of the Product, comprise all unsold lots. 
 “IPF
Patient Data” shall mean data accessible through Seller’s Product regulatory safety database (e.g., the annual safety update reports provided by Seller to the FDA contained therein) and the ARISg global safety database maintained by
Seller, which data exists at the time such databases are transferred by Seller to Purchaser after the Closing and which may include, among other things, safety data generated by or for Seller or its Affiliates in the conduct of the clinical
development of Interferon Gamma-1b for the treatment of patients with idiopathic pulmonary fibrosis; provided, however, that for purposes of clarity, IPF Patient Data shall not be deemed to include any case report forms, data (other than the data
accessible through Seller’s regulatory safety database and the ARISg global safety database described herein), reports (other than the annual safety update reports described herein), publications, abstracts and other information, materials and
patient samples generated by or for Seller or its Affiliates in the conduct of the clinical development of Interferon Gamma-1b for the treatment of patients with idiopathic pulmonary fibrosis. 

“IRS” shall mean the United States Internal Revenue Service. 

“Know-How” shall mean confidential or proprietary information, including, without limitation, Trade Secrets, inventions
(whether or not patentable), discoveries, developments, improvements, enhancements, concepts, ideas, methods, processes, designs, schematics, drawings, formulae, data, technical data and information, specifications, instructions, research and
development information, technology and databases. 
 “Knowledge of Purchaser” or “to Purchaser’s
Knowledge” or any similar such statement shall mean Bala Venkataraman, Virinder Nohria, Rick McElheny and Brian Anderson, or any executive officer or director of Purchaser or Parent, directly involved on behalf of Purchaser or Parent in the
transactions contemplated herein, has or had actual knowledge, or such knowledge as would be reasonably expected to have been obtained after reasonable inquiry, of a fact or matter. 

“Knowledge of Seller” or “to Seller’s Knowledge” or any similar such statement shall mean Lawrence
Kahn, Yip Fong Chia, Carla Fiankin, Sandy Mohan, Frank Zampella, and Bruce Tomlinson, or any executive officer of Seller directly involved in the Product Business, has or had actual knowledge, or such knowledge as would be reasonably expected to
have been obtained after reasonable inquiry, of a fact or matter. 

  
 6 

 “Law” shall mean any foreign, federal, state or local law, statute or any rule,
or regulation promulgated by any Governmental Authority. 
 “Liability” shall mean, collectively, any liability,
indebtedness, guaranty, endorsement, claim, loss, damage, deficiency, cost, expense, obligation, responsibility, or product liability, whether fixed or unfixed, known or unknown, choate or inchoate, liquidated or unliquidated, secured or unsecured,
direct or indirect, matured or unmatured, or absolute, contingent or otherwise. 
 “Losses” shall mean any and all losses,
damages, Liabilities, deficiencies, claims, proceedings, causes of action, costs (including reasonable out of pocket costs of investigation) and expenses, including interest, diminution in value, penalties, settlement costs, judgments, awards,
fines, costs of mitigation, losses in connection with any Environmental Law (including any clean up or remedial action), court costs and fees (including reasonable attorneys’ fees and expenses). 

“Material Adverse Effect” shall mean any change, circumstance, event or effect that has had or is reasonably likely to have
in the future, individually or in the aggregate, a material adverse effect on (i) the condition (financial or otherwise) or results of operation of the Product Business or the Purchased Assets or (ii) the ability of Seller to consummate
the transactions contemplated by this Agreement; provided that no changes, circumstances, events or effects resulting from or arising out of the following shall be taken into account in determining whether a Material Adverse Effect has occurred:
(a) the public announcement of the entering into of this Agreement or the other Ancillary Agreements or the pendency of the transactions contemplated hereby or thereby (including any cancellation or delay of customer orders, any reduction in
sales, any disruption in supplier, partner or similar relationships or any loss of employees), (b) the performance by Seller of any action, or the failure to take any action, in each case at Purchaser’s written request (including email)
pursuant to this Agreement or the other Ancillary Agreements, (c) general economic conditions, (d) general conditions in the industry in which the Product Business is conducted, (e) changes in GAAP or Applicable Law which have general
application, (f) the failure of the business to meet any internal projections or forecasts of revenue or earnings (provided that the underlying cause of such failure shall be taken into account unless such cause is otherwise included in clause
(a) through (e), or (g)), or (g) fire, flood, tornado, earthquake or other acts of nature, acts of terrorism or sabotage, war, regional, national or international calamity, military action or any other similar event or any escalation or
worsening thereof after the date hereof, except to the extent, in the case of the foregoing clauses (c) through (e), such changes, circumstances, events or effects referred to therein have a materially disproportionate impact on the Product
Business relative to the industry in which the Product Business competes as a whole. 
 “Opco” shall have the meaning set
forth in the first paragraph of this Agreement. 
 “Parent” shall have the meaning set forth in the first paragraph of this
Agreement. 
 “Party” or “Parties” shall have the meaning set forth in the first paragraph of this
Agreement. 

  
 7 

 “Patent Assignment Agreement” shall mean that certain patent assignment
agreement in the form attached hereto as Exhibit D. 
 “Patent Rights” shall mean U.S., international or foreign
patents, provisional patent applications, patent applications, design registrations, design registration applications, industrial designs, industrial design applications and industrial design registrations, including any and all divisions,
continuations, continuations-in-part, extensions, substitutions, renewals, registrations, revalidations, reexaminations, reissues or additions, including supplementary certificates of protection, of or to any of the foregoing items. 

“Permitted Encumbrances” shall mean (i) Encumbrances for Taxes, assessments and other governmental charges not yet due
and payable or, if due, either (a) not delinquent or (b) being contested in good faith by appropriate proceedings, (ii) mechanics’, workmen’s, repairmen’s, warehousemen’s, carriers’ or other similar
Encumbrances, including all statutory Encumbrances, arising or incurred in the ordinary course of business and not yet delinquent or, (iii) Encumbrances that do not materially affect the ownership, value or use of the underlying Purchased Asset
for the purpose it is being utilized by Seller or its Affiliates on the Closing Date. 
 “Person” shall mean any natural
person, corporation, unincorporated organization, partnership, association, joint stock company, joint venture, limited liability company, trust or government, or any agency or political subdivision of any government, or any other entity. 

“Post-Closing Tax Period” shall have the meaning set forth in Section 8.8(c). 

“Pre-Closing Tax Period” shall have the meaning set forth in Section 8.8(c). 

“Proceeding” shall mean any litigation, claim, action, dispute, lawsuit, arbitration, dispute resolution process,
cancellation proceeding, opposition proceeding, concurrent use proceeding, reexamination proceeding, nullification proceeding, interference proceeding, priority contest, challenge, protest, inquiry, change demand, order, judgment, hearing,
assessment, or any other proceeding (whether civil, criminal, administrative or investigative), commenced, brought, conducted, or heard by or before any Governmental Authority or arbitrator. 

“Product” shall mean the finished pharmaceutical product containing Interferon Gamma-1b in the formulation approved by the
FDA for the reduction of the frequency and severity of serious infections related to chronic granulomatous disease and delaying time to disease progression in patients with severe, malignant osteopetrosis and sold by Seller under the
Actimmune® trademark prior to the Closing. 
 “Product Business”
shall mean the manufacturing, using, developing, promoting, advertising, marketing, distributing, selling, offering to sell, importing and/or exporting of the Product in the Territory. 

“Product Copyrights” shall mean any and all Copyrights (including, without limitation, any and all Copyright Registrations
and Applications listed on Schedule 1.1(c)) that are Controlled by Seller and/or any of its Affiliates and that relate solely to the Product and/or the Product Business. 

  
 8 

 “Product Domain Names” shall mean any and all active or inactive Domain Names,
that are Controlled by Seller and/or any of its Affiliates and that relate solely to the Product and/or the Product Business, as identified on Schedule 1.1(c). 

“Product Intellectual Property” shall mean the Product Copyrights, Product Domain Names, Product Know-How, Product Patents,
Product Trademarks and Product Trade Secrets, including, without limitation, each of the foregoing as listed on Schedule 1.1(c). 

“Product Know How” shall mean any and all Know-How that is Controlled by Seller and/or any of its Affiliates and that relates
primarily to the Product and/or the Product Business, excluding the Excluded Data and Materials. 
 “Product Master Cell
Bank” or “PMCB” shall mean collectively the following cell banks relating to the Product or the Product Business: (i) the cell bank stored at Fisher BioServices Inc. located at 14665 Rothgeb Dr., Rockville, Maryland,
20850; and (ii) the working cell bank W3110 pHF CYC5, in each of which Seller or its Affiliates have ownership or other rights or interests, whether contractual or otherwise, therein or with respect thereto. 

“Product Master Cell Bank Records” shall mean all records and associated agreements with third party providers relating to
the development, characterization and validation of the PMCB and documenting storage, dispensing and periodic testing of Product Master Cell Bank confirming its integrity and stability, that are owned or Controlled by Seller or its Affiliates. 

“Product Net Sales” shall mean the gross amount invoiced by Purchaser or its Affiliates for Product sales, less:
(i) reasonable and customary cash discounts consistent with the Seller’s past practices, (ii) customary rebates and Chargebacks, consistent with the Seller’s past practices and (iii) sales credits, refunds, returns and
allowances accrued by Purchaser in accordance with GAAP. Such amounts shall be determined from books and records maintained by Purchaser in accordance with GAAP, consistently applied. To the extent that any accrual contemplated by the foregoing
clause (iii) is subsequently adjusted in accordance with GAAP, Purchaser shall notify Seller thereof in writing and the Earnout owing hereunder in respect of the Product Net Sales corresponding to such accrued amounts shall be adjusted
accordingly and the next subsequent Earnout payment hereunder shall be increased or decreased accordingly. 
 “Product
Patents” shall mean any and all Patent Rights that are Controlled by Seller and/or any of its Affiliates and that relate primarily to the Product and/or the Product Business, as identified on Schedule 1.1(c), and including, without
limitation, the Genentech Patents and the Snitman Patents. 
 “Product Records” shall mean all files, documents,
instruments, papers, books and records Controlled by Seller and/or any of its Affiliates, whether in electronic or tangible form, that relate primarily to the Product, the Product Business and/or the Product Intellectual Property, including, without
limitation, any and all pricing lists, customer lists, vendor lists, financial data, research and development files, marketing materials, regulatory files, adverse event reports and files; equipment specifications; analytical specifications and
validation reports; Product batch records; bills of material; packaging specifications; approved and rejected vendor lists and audits; Product complaints, clinical studies and all documentation relating thereto; all

  
 9 

 
documentation associated with the Product Intellectual Property; copies of all filings (and supporting documentation) with Governmental Authorities, including, but not limited to, any and all
Product NDAs and BLAs; component and labeling purchasing specifications; packaging and quality control SOPs; stability data, records, charts, reports and applicable SOPs; quality assurance/control data, records, charts, reports, and applicable SOPs;
budgets; pricing guidelines; ledgers; journals; Assumed Contracts; Promotional Materials; operating data and plans; sales data; target lists; file histories, file wrappers, correspondence, application documents, registration documents, search
reports, documents concerning the prosecution history, enforcement or maintenance of rights, or restrictions on use, with respect to the Product Intellectual Property, whether or not required to be kept or maintained under any Law; but excluding
(i) the Excluded Data and Materials and (ii) any items to the extent that any Applicable Law prohibits their transfer. 

“Product Returns” shall mean returns of Product by customers. 

“Product Trademarks” shall mean any and all Trademarks that are Controlled by Seller and/or any of its Affiliates and that
relate solely to the Product and/or the Product Business, as identified on Schedule 1.1(c). “Product Trademarks” shall not include the Seller Marks. 

“Product Trade Secrets” shall mean any and all Trade Secrets that are Controlled by Seller and/or any of its Affiliates and
that relate primarily to the Product and/or the Product Business. 
 “Promotional Materials” shall mean any and all
physician lists, customer lists, marketing studies, marketing plans and strategies, sales force training materials, market research materials, and all advertising, selling, and promotional materials and other similar information and data, including,
without limitation, records of sales and cost data for the twelve (12) months ended April 30, 2012, and as of the day prior to the Closing Date, to the extent the foregoing relate primarily to the Product and/or the Product Business, and
to the extent the foregoing are within the Seller’s or its Affiliates’ possession as of the Closing Date. 
 “Property
Taxes” shall have the meaning set forth in Section 8.8(c). 
 “Purchased Assets” shall mean,
collectively, the assets of Seller set forth below: 
 (i) the Product; 

(ii) all Inventory identified on Schedule 1.1(a); 

(iii) the Assumed Contracts; 

(iv) the Regulatory Approvals identified on Schedule 1.1(b); 

(v) the Promotional Materials; 

(vi) the Product Records; 
 (vii)
the Product Intellectual Property; 

  
 10 

	 	(viii)	the Product Master Cell Bank and Product Master Cell Bank Records, which are listed on Schedule 1.1(e); and 

  

	 	(ix)	all of Seller’s right, title and interest in and to each and all of the foregoing assets set forth in (i) – (viii), supra, including, without limitation, any and all of Seller’s and its
Affiliates’ rights to bring any and all causes of action, either in law or in equity, for past, present or future infringement of any of the Product Intellectual Property. 

“Purchase Price” shall have the meaning set forth in Section 2.1(b). 

“Purchaser” shall have the meaning set forth in the first paragraph of this Agreement. 

“Purchaser Confidential Information” shall have the meaning set forth in Section 10.1(b). 

“Purchaser Indemnified Parties” shall have the meaning set forth in Section 9.1(a). 

“Purchaser Labeling” shall mean the printed labels, labeling and packaging materials, including printed carton, container
labels and package inserts, to be prepared by Purchaser after the Closing Date and bearing Purchaser’s name for, or in connection with, packaging of the Product. 

“Quality Agreement” shall mean the Quality Agreement executed by and between Seller and Boehringer-Ingelheim in connection
with the execution of the B-I Supply Agreement, which Quality Agreement will be one of the Assumed Contracts to be assigned to Opco as part of the Purchased Assets. 

“Regulatory Approvals” shall mean all applications for regulatory approval, including new drug applications, abbreviated new
drug applications, new drug submissions, and any comparable applications and submissions, together with any and all supplements or modifications or amendments thereto, whether existing, pending, withdrawn or in draft form, prepared and submitted to
any Governmental Authority in the Territory with respect to the Product, along with all supporting files, data, studies and reports relating thereto (in tangible and electronic form) and all technical and other information contained therein. 

“Schedules” shall refer to the schedules to this Agreement which are hereby incorporated by reference into this Agreement.

 “Seller” shall have the meaning set forth in the first paragraph of this Agreement. 

“Seller Bank Account” shall have the meaning set forth in Section 2.1(b)(i). 

“Seller Confidential Information” shall have the meaning set forth in Section 10.1(c). 

“Seller Disclosure Schedule” shall have the meaning set forth in the first paragraph of Article III. 

“Seller Indemnified Parties” shall have the meaning set forth in Section 9.1(b). 

  
 11 

 “Seller Marks” shall mean all Trademarks Controlled by Seller, other than the
Product Trademarks, that are used in connection with the Product Business and the Assumed Liabilities as of the Agreement Date. 

“Seller SEC Filing” shall have the meaning set forth in Section 3.13(a). 

“Snitman Patents” shall mean United States Patent No. 6,936,695, United States Patent No. 6,936,694 (now reissued
as US RE39,821E), Canadian Patent No. 1,341,561, and any and all Patent Rights related to the foregoing. 
 “Straddle
Period” shall have the meaning set forth in Section 8.8(c). 
 “Taxes” shall mean all federal, state,
local, foreign and other income, net income, gross income, gross receipts, sales, use, ad valorem, transfer, capital stock, franchise, profits, license, service, add on or alternative minimum tax, occupancy, withholding, payroll, fringe benefits,
employment, employees’ income withholding, foreign or domestic withholding, unemployment, disability, excise, severance, stamp, value added, occupation, premium, property (including, real property and personal property taxes and any
assessments, special or otherwise), environmental, windfall profits, customs, duties or other taxes, and any fees, assessments, levies, tariffs or charges of any kind that are in the nature of a tax, together with any interest and any penalties,
additions to tax or additional amounts with respect thereto (and “Tax” means any one of the foregoing Taxes). 

“Tax Return” shall mean any return, declaration, report or statement required to be filed with a Governmental Authority in
respect to any Tax (including any attachments thereto, and any amendment thereof), including any information return, claim for refund, amended return or declaration of estimated Tax. 

“Territory” shall mean the United States, Canada and Japan. 

“Third Party” shall mean any Person other than Purchaser, Parent, Opco or Seller, or an Affiliate of any of them. 

“Third Party Claim” shall mean any Proceeding at law or suit in equity by or against a Third Party as to which
indemnification will be sought hereunder. 
 “Trademarks” shall mean any and all U.S., international or foreign trademarks,
service marks, trade names, service names, brand names, product names, trade dress, trade styles, logos, symbols, and other product or service source identifiers and general intangibles of a like nature, together with all goodwill associated with
any of the foregoing, along with all applications, registrations, renewals and extensions therefor. 
 “Trade Secrets”
shall mean information, including, without limitation, any formula, program, device, method, technique, and/or process, that: (i) derives independent economic value, actual or potential, from not being generally known to, and not being readily
ascertainable by proper means by, any Third Party who can obtain economic value from its disclosure or use, and (ii) is the subject of efforts that are reasonable under the circumstances to maintain its secrecy. 

  
 12 

 “Transaction Documents” shall mean this Agreement and the Ancillary Agreements.

 “Transfer Taxes” shall have the meaning set forth in Section 8.8(b). 

“Transition Services Agreement” shall mean that certain transition services agreement in the form attached hereto as
Exhibit C. 
 “Treasury Regulations” shall mean the income tax regulations issued under the Code. 

Section 1.2 Construction. 

(a) The words “hereof,” “herein” and “hereunder” and words of like import used in this Agreement shall refer to
this Agreement as a whole and not to any particular provision of this Agreement. 
 (b) The captions herein are included for convenience of
reference only and shall be ignored in the construction or interpretation hereof. References to Articles, Sections, Exhibits, and Schedules are to Articles, Sections, Exhibits, and Schedules of this Agreement unless otherwise specified. 

(c) All Exhibits and Schedules annexed hereto or referred to herein are hereby incorporated in and made a part of this Agreement as if set
forth in full herein. Any capitalized terms used in any Exhibit or Schedule but not otherwise defined therein, shall have the meaning as defined in this Agreement. 

(d) Any singular term in this Agreement shall be deemed to include the plural, and any plural term the singular, and words denoting either
gender shall include both genders as the context requires. Where a word or phrase is defined herein, each of its other grammatical forms shall have a corresponding meaning. 

(e) Whenever the words “include,” “includes” or “including” are used in this Agreement, they shall be deemed to
be followed by the words “without limitation,” whether or not they are in fact followed by those words or words of like import. 

(f) The use of the word “or” shall not be exclusive. 

(g) A reference to any legislation or to any provision of any legislation shall include any modification, amendment, re-enactment thereof, any
legislative provision substituted therefore and all rules, regulations and statutory instruments issued or related to such legislation. 

(h) Any rule of construction to the effect that ambiguities are to be resolved against the drafting party shall not be applied in the
construction or interpretation of this Agreement. No prior draft of this Agreement nor any course of performance or course of dealing shall be used in the interpretation or construction of this Agreement. No parol evidence shall be introduced in the
construction or interpretation of this Agreement unless the ambiguity or uncertainty in issue is plainly discernable from a reading of this Agreement without consideration of any extrinsic evidence. 

  
 13 

 (i) The Parties agree that any exception or qualification set forth in the Seller Disclosure
Schedule with respect to a particular representation or warranty contained herein shall be deemed to be an exception or qualification with respect to other representations and warranties contained in this Agreement to the extent the applicability of
the disclosure to each other representation and warranty is reasonably apparent from the text of the disclosure made. Nothing in the Seller Disclosure Schedule is intended to broaden the scope of any representation, warranty or covenant of Seller
contained in this Agreement. 
 ARTICLE II 

THE TRANSACTION 

Section 2.1 Purchase and Sale of Purchased Assets. 

(a) Upon the terms and subject to the conditions set forth in this Agreement, at the Closing, Seller shall sell, assign, transfer, convey and
deliver to Purchaser, and Purchaser shall purchase, acquire and accept, all of Seller’s right, title and interest in and to the Purchased Assets, free and clear of all Encumbrances other than Permitted Encumbrances; provided that Opco shall
purchase, acquire and accept the Inventory, B-I Supply Agreement and Quality Agreement in lieu of Purchaser. 
 (b) As consideration for the
transactions contemplated hereby (the “Purchase Price”), Purchaser shall make the following payments to Seller: 
  

	 	(i)	Closing Cash Payment. At Closing, Purchaser shall make a cash payment of Fifty Five Million Dollars ($55,000,000) (the “Closing Cash Payment”) by wire transfer of immediately available funds to a
bank account in the United States identified by Seller to Purchaser in writing at least two (2) Business Days prior to the Closing Date (the “Seller Bank Account”). 

 

	 	(ii)	Additional Consideration. 

 A. Earnout. On each of the one (1) year and two
(2) year anniversaries of the Closing, Purchaser shall pay to Seller a cash payment (each an “Earnout” and together, the “Earnouts”) by wire transfer of immediately available funds to the Seller Bank Account
or, if applicable, to an alternate bank account in the United States identified by Seller to Purchaser in writing (the “Alternate Seller Bank Account”), within forty-five (45) days following the end of each Annual Period, such
amount as calculated pursuant to the formulas set forth below: 
  

	 	•	 	12.5% of total Product Net Sales from $0 - $10,000,000; and 

  

	 	•	 	7.5% of total Product Net Sales from $10,000,001 - $20,000,000. 

 Product Net Sales shall be
calculated on an Annual Period basis and payments of the foregoing Earnouts will be paid within forty-five (45) days after the end of each three (3) month period within each of the first and second Annual Periods. 

  
 14 

	 	(iii)	Assumed Liabilities. At the Closing, Purchaser shall assume from Seller, and thereafter pay, perform and discharge when due, the Assumed Liabilities. 

(c) The B-I Purchase Orders shall constitute Assumed Contracts, provided, however, Seller shall, at Seller’s expense, pay, perform and
discharge on Purchaser’s behalf when due the amounts payable to Boehringer-Ingelheim under the B-I Purchase Orders. If Closing occurs prior to the transfer of title from Boehringer-Ingelheim to Seller of Product under the B-I Purchase Orders,
the Parties acknowledge and agree that Purchaser may directly instruct Boehringer-Ingelheim to ship or have shipped the Product under the B-I Purchase Orders to Opco pursuant to the terms of the B-I Supply Agreement. If Closing occurs after the
transfer of title from Boehringer- Ingelheim to Seller of Product under the B-I Purchase Orders, Purchaser acknowledges and agrees that such Product shall remain at the United States facilities maintained by CORD Logistics, Inc. where CORD
Logistics, Inc. shall continue to store and process the Product under the Distribution Services Agreement between CORD Logistics, Inc. and InterMune Pharmaceuticals Inc., dated January 15, 1999, as amended from time to time, but title to such
Product shall be transferred to Opco, without further consideration, at the time of Closing as part of the Purchased Assets. 

Section 2.2 Excluded Assets. The Parties acknowledge and agree that Seller is not selling, conveying, transferring,
assigning, or delivering, or assigning any rights whatsoever to the Excluded Assets to Purchaser, and Purchaser is not purchasing, taking delivery of or acquiring any rights whatsoever to the Excluded Assets from Seller. 

Section 2.3 Assumed Liabilities. Upon the terms and subject to the conditions set forth in this Agreement, at the
Closing, Purchaser shall assume and agree to pay, perform or otherwise discharge, in accordance with their respective terms and subject to the respective conditions thereof, only the following Liabilities (collectively, the “Assumed
Liabilities”); provided that Opco shall assume any such Liability in lieu of Purchaser with respect to the Inventory, B-I Supply Agreement and Quality Agreement: 

(a) Any Liability arising on or after the Closing under any Assumed Contract (other than any Liability arising out of or relating to a breach
of such Assumed Contract which occurred prior to the Closing); 
 (b) Any Liability arising out of the conduct of the Product Business by
Purchaser after the Closing, including any Liabilities and obligations arising out of or resulting from product liability claims for the Product but only with respect to Product which is sold by Purchaser after the Closing; 

(c) Any Liability arising after the Closing for Taxes imposed with respect to the Product Business or the Purchased Assets that are
attributable to the ownership, sale, operation or use of the Product Business or the Purchased Assets following the Closing Date; 
 (d)
Property Taxes and Transfer Taxes to the extent specifically allocated to Purchaser pursuant to Section 8.8; and 
 (e) Any other
Liability specifically set forth on Schedule 2.3(e) hereto. 

  
 15 

 (f) For the avoidance of doubt, the Parties acknowledge that in no event shall the provisions of
this Section 2.3 be construed to limit Purchaser’s, Parent’s or Opco’s obligations under Article IX. 

Section 2.4 Excluded Liabilities. 

(a) The Parties hereby acknowledge and agree that, other than the Assumed Liabilities, or as otherwise specifically provided in the Transaction
Documents, Purchaser shall not be responsible for, assume, or be obligated to pay, perform or otherwise discharge any Liabilities or obligations of Seller, whether or not related to the Product Business (collectively, the “Excluded
Liabilities”), which Excluded Liabilities shall include, but not be limited to, (i) any obligation or Liability of Seller created as a result of this Agreement, (ii) any Liability relating to Product sold prior to the Closing
Date, or the operation of the Product Business prior to the Closing Date, (iii) those items set forth on Schedule 2.4(a), and (iv) all liabilities with respect to any Taxes owed by Seller, including any liability of Seller for the
Taxes of any other Person under Treasury Regulation Section 1.1502-6 (or any similar provision of state, local or foreign law), as a transferee, or as a result of a Tax sharing of similar agreement, and Taxes otherwise imposed with respect to
the Product Business or the Purchased Assets that are attributable to the ownership, sale, operation or use of the Product Business or the Purchased Assets on or prior to the Closing Date. For the avoidance of doubt, the Parties acknowledge that in
no event shall the provisions of this Section 2.4 be construed to limit Seller’s obligations under Article IX. 
 (b)
The Parties hereby acknowledge and agree that, other than as provided in the Transaction Documents, Seller shall not be responsible for, assume, or be obligated to pay, perform or otherwise discharge any obligations or liabilities of Purchaser. The
Parties acknowledge that in no event shall the foregoing sentence be construed to limit Seller’s obligations under Article IX. 

Section 2.5 Closing Date. Unless this Agreement shall have been terminated pursuant to Article VII, the consummation
of the transactions contemplated by Section 2.1 (the “Closing”) shall take place at the offices of Latham & Watkins LLP, 140 Scott Drive, Menlo Park, CA 94025 at 10:00 a.m., PDT, and in such other places as are
necessary to effect the transactions to be consummated at the Closing, on the fifth (5th) Business Day immediately following the satisfaction or, to the extent permitted, waiver of all of the conditions in Article VII (other than those
conditions which by their nature are to be satisfied or, to the extent permitted, waived at the Closing but subject to the satisfaction or, to the extent permitted, waiver of such conditions), or at such other time, date and place as shall be
determined by mutual agreement of the Parties (such date of the Closing being herein referred to as the “Closing Date”). The Closing shall be deemed to have become effective as of 12:01 a.m., PDT on the Closing Date. 

Section 2.6 Purchaser Obligations. At the Closing, Purchaser shall (i) deliver to Seller the Closing Cash Payment and
(ii) execute and deliver to Seller the following: 
 (a) the Bills of Sale; 

(b) the Assignment and Assumption Agreements; 

  
 16 

 (c) the Transition Services Agreement; 

(d) the Patent Assignment Agreement; 

(e) the certificate required by Section 7.3(a); 

(f) the Domain Name Assignment Agreement; 

(g) its acknowledgment to and acceptance of the waiver and consent of BoehringerIngelheim, as described in Section 7.2(e) hereof;
and 
 (h) such other documents and instruments as Seller may reasonably request to consummate the transactions described in
Section 2.1. 
 Section 2.7 Seller Obligations. At the Closing, Seller shall execute and deliver to
Purchaser, the following: 
 (a) the Bills of Sale; 

(b) the Assignment and Assumption Agreements; 

(c) the Transition Services Agreement; 

(d) the Patent Assignment Agreement; 

(e) the Domain Name Assignment Agreement; 

(f) the B-I Supply Agreement, Quality Agreement and waiver and consent of Boehringer-Ingelheim, as described in Section 7.2(e)
hereof; 
 (g) a confirmation receipt reflecting receipt of the Closing Cash Payment; 

(h) a certificate from Seller under Treasury Regulations Section 1.1445-2 certifying Seller’s non-foreign status; 

(i) the certificate required by Section 7.2(a); and 

(j) such other documents and instruments as Purchaser may reasonably request to consummate the transactions described in
Section 2.1. 
 Section 2.8 Allocation of Purchase Price. Seller and Purchaser shall allocate the Purchase
Price (and Assumed Liabilities, to the extent properly taken into account under the Code) among the Purchased Assets for tax purposes in accordance with Section 1060 of the Code. A draft allocation schedule shall be prepared by Purchaser and
delivered to Seller not later than thirty (30) days after the Closing Date for Seller’s review and comment. Seller and Purchaser shall work in good faith to resolve any disputes relating to the draft allocation schedule (such allocation
schedule as finally agreed to by Purchaser and Seller, the “Allocation Schedule”). The Allocation Schedule shall be revised as mutually agreed by Purchaser and Seller to reflect any adjustment to the Purchase Price pursuant
to the provisions of this 

  
 17 

 
Agreement. Purchaser and Seller shall file all Tax Returns (including, but not limited to, a Form 8594 (Asset Acquisition Statement under Section 1060 of the Code)) with respect to the
transactions contemplated by this Agreement consistently with the Allocation Schedule and any adjustments thereto, unless otherwise required by Applicable Law. 

Section 2.9 Assignability and Consents. Notwithstanding anything to the contrary contained in this Agreement, but subject
to Section 7.2, if the sale, assignment, transfer, conveyance or delivery or attempted sale, assignment, transfer, conveyance or delivery to Purchaser of any Purchased Assets (i) is prohibited by any Applicable Law or
(ii) would require any consents, waivers, approvals or authorizations of a Third Party or Governmental Authority (a “Consent”) and such Consents shall not have been obtained prior to the Closing and an attempted
assignment thereof without such Consent would constitute a breach thereof, then in either case, the Closing will proceed without the sale, assignment, transfer, conveyance or delivery of such Purchased Assets and this Agreement shall not constitute
an agreement for the sale, assignment, transfer, conveyance or delivery of such Purchased Asset. In the event that the Closing proceeds without the sale, assignment, transfer, conveyance or delivery of any such Purchased Asset, then following the
Closing, the Parties shall use their commercially reasonable efforts, and cooperate with each other, to obtain promptly such Consents; provided, however, that Purchaser shall not be required to pay any consideration to obtain any such Consent.
Pending receipt of such Consents, the Parties shall cooperate with each other in any mutually agreeable, reasonable and lawful arrangements designed to provide to Purchaser the benefits of and the obligations associated with use of such Purchased
Asset that it would have obtained or been subject to had the asset been conveyed to Purchaser at the Closing. To the extent that Purchaser is provided the benefits pursuant to this Section 2.9 of any Assumed Contract, Purchaser shall
(x) perform for the benefit of the other parties thereto the obligations of Seller or any Affiliate of Seller thereunder, which arise after the Closing, and (y) shall satisfy any related Liabilities with respect to such Assumed Contract
that, but for the lack of a Consent to assign such obligations or Liabilities to Purchaser, would be Assumed Liabilities. Once Consent for the sale, assignment, transfer, conveyance or delivery of any such Purchased Asset not sold, assigned,
transferred, conveyed or delivered at the Closing is obtained or given, Seller shall promptly assign, transfer, convey and deliver such Purchased Asset to Purchaser at no additional cost to Purchaser. 

Section 2.10 License Grant. Seller hereby grants Purchaser, on Seller’s behalf and on behalf of any applicable
Affiliate, a non-exclusive, royalty-free, sublicenseable license, under Know-How Controlled by Seller, to use the IPF Patient Data solely for the treatment and support of patients using the Product; provided that, for the avoidance of doubt,
Purchaser shall not use any of the IPF Patient Data to seek regulatory approval of or to commercialize the Product for the treatment of idiopathic pulmonary fibrosis. 

ARTICLE III 

REPRESENTATIONS AND WARRANTIES OF SELLER 

Seller represents and warrants to Purchaser as of the date hereof, but subject to such exceptions as are specifically disclosed in the
disclosure schedule referencing the appropriate Sections hereof (unless the applicability and relevance of the disclosure to another representation or warranty is readily apparent on the face of such disclosure, in which case such disclosure shall

  
 18 

 
also apply to such other representations or warranty) supplied by Seller and dated as of the date hereof (the “Seller Disclosure Schedule”), as follows: 

Section 3.1 Organization and Authority. Seller is a corporation duly organized, validly existing and in good standing under
the laws of the State of Delaware. Seller has all necessary corporate power and corporate authority, and has taken all actions necessary, to execute and deliver the Transaction Documents, and the transactions contemplated thereby, and effect the
transactions contemplated thereby and has duly authorized the execution, delivery and performance of the Transaction Documents and transactions or documents contemplated thereby by all necessary corporate action. Seller has all corporate power and
corporate authority necessary to own its assets and carry on the Product Business as currently being conducted by Seller. The Transaction Documents will be upon the Closing, the valid and legally binding obligations of Seller, enforceable against it
in accordance with their terms, subject to applicable bankruptcy moratorium, reorganization, insolvency and similar laws of general application relating to or affecting the rights and remedies of creditors generally and to general equitable
principles (regardless of whether in equity or at law). 
 Section 3.2 Purchased Assets; Title to Purchased
Assets. 
 (a) Except as set forth on Section 3.2 of the Seller Disclosure Schedule, the Purchased Assets
collectively constitute all of the properties, rights, titles, interests and other tangible and intangible assets owned by Seller and/or any of its Affiliates and used by Seller and/or any of its Affiliates to conduct the Product Business consistent
with past practice. 
 (b) Seller has good and marketable title to the Purchased Assets owned by Seller free and clear of any Encumbrances,
except for the Permitted Encumbrances. Seller has not received any notice of any adverse claims of ownership to the Purchased Assets owned by Seller, and to Seller’s Knowledge, no facts or circumstances exist which would provide a reasonable
basis for any such adverse claim of ownership of any of the Purchased Assets owned by Seller. Upon delivery to Purchaser at the Closing of the Bills of Sale, Domain Name Assignment Agreement, Patent Assignment Agreement, and the Assignment and
Assumption Agreements, Seller will thereby sell, transfer, convey and assign to Purchaser good and marketable title to the Purchased Assets, free and clear of all Encumbrances other than Permitted Encumbrances, subject to the terms and conditions of
this Agreement. 
 Section 3.3 Consents; Non-Contravention. 

(a) Except for the requisite filings under the HSR Act, if any, and the expiration or termination of the waiting period thereunder, and except
for all filings and other actions contemplated by the Transaction Documents (including the necessary transfer of filings, notices and approvals required to transfer the Regulatory Approvals from Seller to Purchaser), the execution, delivery and
performance by Seller of the Transaction Documents and the consummation by Seller of the transactions contemplated thereby will not require any notice to, filing with, or the consent, approval or authorization of, any Person or Governmental
Authority. 
 (b) Except as set forth on Section 3.7 of the Seller Disclosure Schedule, neither the execution and delivery of the
Transaction Documents nor the consummation of the transactions 

  
 19 

 
contemplated thereby will (i) violate or result in a breach or result in the acceleration or termination of, or the creation in any Third Party of the right to accelerate, terminate, modify
or cancel, any Assumed Contract, (ii) conflict with, violate or result in a breach of any provision of the certificate of incorporation, or by-laws of Seller, (iii) conflict with or violate in any material respect Applicable Law, or
(iv) conflict with, violate or result in a breach of any material agreement, instrument or arrangement to which Seller is subject, including any agreement affecting Seller’s ownership of, or ability to assign, the Product Intellectual
Property. 
 Section 3.4 Regulatory Approvals. 

(a)Section 3.4(a) of the Seller Disclosure Schedule sets forth a complete and correct list of all Regulatory Approvals. Seller has
provided to Purchaser complete and correct copies of the Regulatory Approvals or Purchaser has had access to such copies of the Regulatory Approvals. 

(b) Seller is in material compliance with all of the Regulatory Approvals listed on Section 3.4(a) of the Seller Disclosure
Schedule, and, since the time Seller acquired its rights in the Product, Seller has not received any notification or other communication, written or oral, from any Third Party with respect to any alleged or possible violation with respect to any
such Regulatory Approvals, and to Seller’s Knowledge, there are no facts or circumstances that would form a reasonable basis for any such violation. 

(c) The Regulatory Approvals are in full force and effect and have been duly and validly issued. The U.S. Regulatory Approval is in good
standing, has not been revoked, rescinded, amended or modified, and, to Seller’s Knowledge, no event has occurred or notification or other communication been received by Seller from the FDA or other Governmental Authority, a notified body or
any other party that would materially adversely affect or otherwise jeopardize the FDA approval status of the Product. To the Knowledge of Seller, no applications made or other materials submitted by Seller to the FDA or other Governmental Authority
or a notified body with respect to the Product contained an untrue statement of material fact when submitted, or omitted to state a material fact when submitted which was required to be stated therein or necessary in order to make the statements
contained therein, in light of the circumstances under which they were made, not misleading. 
 (d) The Regulatory Approval files of Seller
have been maintained in accordance with reasonable industry standards. Seller has in its possession or control, or has access to, copies of all the material documentation filed in connection with filings made by Seller for Regulatory Approval of the
Product, including the complete regulatory chronology for each Regulatory Approval (if applicable) and Seller will, to the extent any such materials are not delivered pursuant to the terms of this Agreement, upon request of Purchaser make such
materials available for review and copying by Purchaser and its representatives. 
 Section 3.5 Compliance with Laws and
Litigation. 
 (a) Except with respect to any matter relating to or arising from Regulatory Approvals (which is addressed in
Section 3.4), with respect to the Product, the Product Business, 

  
 20 

 
the Purchased Assets and the Assumed Liabilities, Seller is in material compliance with all Applicable Laws. 

(b) Except with respect to routine administrative proceedings conducted with respect to Regulatory Approvals conducted in the Seller’s
ordinary and usual course of conduct of the Product Business, there are no Proceedings, including any action or investigation by the U.S. Department of Justice, Office of the Inspector General, or any Governmental Authority, existing, pending, or to
the Knowledge of Seller, threatened against or affecting Seller, with respect to the Product, the Product Business, the Purchased Assets or the Assumed Liabilities or with respect to this Agreement or the transactions contemplated hereby, and there
are no Proceedings pending in which Seller is the plaintiff or claimant and which relate to the conduct of Seller with respect to the Purchased Assets or the Product Business prior to the Closing Date. Seller is not subject to any Proceedings, nor,
to the Knowledge of Seller, are any Proceedings threatened, which, in any such case, that would reasonably be expected to impair or delay its ability to perform its obligations under this Agreement. 

Section 3.6 No Material Adverse Change. 

(a) Except as set forth on Section 3.6 of the Seller Disclosure Schedule, since January 1, 2010, there has been no Material
Adverse Effect on the Product Business or the Purchased Assets; (b) there has been no damage or impairment to, or destruction or loss of, the Purchased Assets, that had or would reasonably be expected to have a Material Adverse Effect on the
Product Business or the Purchased Assets; (c) there has been no sale, assignment, transfer or Encumbrance of the Purchased Assets outside the ordinary course of business; and (d) there has been no change in the contingent obligations of
Seller by way of guaranty, endorsement, indemnity, warranty or otherwise that would reasonably be expected to have a Material Adverse Effect. 

(b) Since January 1, 2010, Seller has, consistent with the conduct of the Product Business during the twenty-four (24) months prior
to the Agreement Date: (i) continued and conducted the Product Business in Seller’s ordinary and usual course of business, and (ii) maintained its relationships with suppliers, distributors, customers and others having material
business relationships with Seller related to the Product Business. 
 Section 3.7 Assumed Contracts. 

(a) Section 3.7 of the Seller Disclosure Schedule sets forth a complete and correct list of each of the Assumed Contracts. Except
as set forth in Section 3.7 of the Seller Disclosure Schedule, the Assumed Contracts constitute all of the contracts to which Seller or any of its Affiliates is a party or is otherwise bound and that are material to or otherwise relate
solely or primarily to the Purchased Assets and/or the Product Business. Seller has delivered to or made available to Purchaser true and complete copies of all such Assumed Contracts and any other contracts or agreements identified on Schedule
1.1(d). All such Assumed Contracts are, as to Seller (and, as to the other parties thereto, to the Knowledge of Seller), legal, valid and binding agreements in full force and effect and enforceable in accordance with their respective terms
(subject to applicable bankruptcy moratorium, reorganization, insolvency and similar laws of general application relating to or affecting the rights and remedies of creditors generally and to 

  
 21 

 
general equitable principles (regardless of whether in equity or at law)) and, subject to Section 2.9, may be transferred to the Purchaser pursuant to this Agreement and, as of the
Closing Date and subject to the provisions of each such Assumed Contract, will continue in full force and effect in each case without the consent, approval, or act, or the making of any filing with, any other party thereto. 

(b) Seller is not in material breach or default, and no event has occurred that with notice or lapse of time would constitute a material breach
or default by Seller permitting termination, modification, or acceleration, under any Assumed Contract of the Seller Disclosure Schedule. To the Knowledge of Seller, no other party to any Assumed Contract is in material breach or default under, or
has repudiated any material provision of, any Assumed Contract, and no event has occurred and no condition or state or facts currently exists which, with time or the giving of notice, or both, would constitute such a material default or breach by
such other party. 
 Section 3.8 Inventory and Returns. 

(a) Section 3.8(a) of the Seller Disclosure Schedule sets forth a complete and correct list of the Inventory as of May 15,
2012, as the same will be revised as of the day prior to the Closing Date. The Inventory has been produced or manufactured in accordance with all Applicable Law and Regulatory Approvals. 

(b) Since January 1, 2010, Seller has not (i) materially altered its distribution practices or terms with respect to the Product, or
(ii) materially altered its activities and practices with respect to inventory levels of the Product maintained at the wholesale, chain, institutional or retail levels in any material respect. 

(c) Section 3.8(c) of the Seller Disclosure Schedule sets forth, on a monthly basis, the returns of the Product for the one year
period ended May 15, 2012, as the same will be revised as of the day prior to the Closing Date. 
 (d) All Inventory included in the
Purchased Assets shall be fully paid for, saleable and in good and marketable condition and shall be in compliance with all Laws applicable to its manufacture, labeling and storage. 

(e) All Inventory identified on Schedule 1.1(a) shall be provided to Opco without additional consideration. 

Section 3.9 Tax Matters. 

(a) There are no Encumbrances for Taxes on any of the Purchased Assets other than Permitted Encumbrances (within the meaning of clause
(i) of such definition). 
 (b) Seller has timely filed all Tax Returns that were required to be filed relating to the Product Business
or the Purchased Assets and has paid all Taxes shown thereon as owing, except where the failure to file Tax Returns or to pay Taxes would not have a Material Adverse Effect. 

(c) Except as disclosed on Schedule 3.9(c), there are pending or ongoing against Seller no federal, state, local or foreign audits,
suits, proceedings, claims or administrative 

  
 22 

 
proceedings or, to the Knowledge of Seller, investigations, for Taxes of Seller relating to the Product Business or the Purchased Assets or any Tax Returns of Seller relating to the Product
Business or the Purchased Assets that could result in (i) a material Encumbrance on the Purchased Assets or (ii) material Taxes for which the Purchaser Indemnified Parties may be liable. 

(d) Seller has not received any written ruling concerning Taxes of Seller with respect to the Product Business or the Purchased Assets from any
taxing authority. 
 (e) Except as disclosed on Schedule 3.9(e), during the three (3) year period ending on the date of this
Agreement, no jurisdiction where Seller does not file a Tax Return has made a claim in writing that Seller is required to file a Tax Return relating to the Product Business or the Purchased Assets for such jurisdiction or that any Taxes relating to
the Product Business of the Purchased Assets are due as a result of doing any business in such jurisdiction. 
 Section 3.10
Intellectual Property. 
 (a) Seller is the owner or licensee of all right, title and interest in and to, or otherwise has the
right to use, the Product Intellectual Property, free and clear of any Encumbrance, except for the Permitted Encumbrances; Seller has the full and unrestricted right, power and authority to grant, convey, transfer and assign to Purchaser all of
Seller’s (and any of its Affiliates’) right, title and interest in and to the Product Intellectual Property; and Seller’s grant, conveyance, transfer and assignment to Purchaser of all of Seller’s (and any of its
Affiliates’) right, title and interest in and to the Product Intellectual Property will not violate or breach any Assumed Contract. 

(b) Schedule 1.1(c) sets forth a true and complete list of all Product Intellectual Property, and Schedule 1.1(d) sets forth a
true and complete list of all Assumed Contracts through which the Seller (and any of its Affiliates) has obtained rights to any Product Intellectual Property. 

(c) None of the Product Patents is involved in any Proceeding (including, but not limited to, any Proceeding challenging the ownership, right
to use, validity, enforceability, and/or any allegation of infringement, of any of the Product Patents (and whether under the Hatch Waxman Act, the Biologics Price Competition and Innovation Act, or other applicable Law)). To the Knowledge of
Seller, no inequitable conduct (i.e., any conduct that would be in violation of 37 C.F.R. §1.56, or its foreign equivalent, if applicable) was committed in the prosecution of any of the Product Patents owned by Seller. 

(d) Except as set forth in Section 3.10 of the Seller Disclosure Schedule, to the Knowledge of Seller, none of the Product
Trademarks, Product Copyrights or Product Domains is involved in any Proceeding. 
 (e) To the Knowledge of Seller, all maintenance fees,
annuity fees or renewal fee payments have been timely paid, as and if applicable, for each of the Product Patents, Product Trademarks, Product Copyrights and Product Domain Names owned by the Seller. 

  
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 (f) There are no pending or, to the Knowledge of Seller, threatened Proceedings (i) based
upon, challenging, or seeking to deny or restrict, the Seller’s (or, as applicable, any of its Affiliates’) use of any of the Product Intellectual Property, and/or (ii) alleging that the manufacture, use, sale, offer for sale, import,
or export of the Product by Seller (or, as applicable, by any of its Affiliates), or the operation of the Product Business, infringes the rights of any Third Party in and to any Intellectual Property. 

(g) To the Knowledge of Seller, no Third Party is engaging in any activity that infringes or misappropriates the Product Intellectual Property.
Neither Seller nor its Affiliates has received any notice from any Third Party, under either the Hatch Waxman Act or the Biologics Price Competition and Innovation Act, asserting any position of non-infringement, invalidity or unenforceability of
any of the Product Patents. 
 (h) Seller has taken all action reasonable and commensurate with industry best practices: (i) to protect,
preserve and maintain the secrecy, confidentiality and value of the Product Trade Secrets and the Product Know-How, and thus, to the Knowledge of Seller, the Product Trade Secrets and/or Product Know-How are not part of the public knowledge or
literature, and have not been used, divulged or appropriated either for the benefit of any Third Party or to the detriment of Seller; and (ii) to vest in Seller all right, title, and interest in and to any and all Product Intellectual Property
conceived, created or developed by all former and current employees and contractors of Seller or its Affiliates, and thus, to the Knowledge of Seller, no former or current employees and/or contractors of Seller or its Affiliates own, hold or
possess, in their individual or any other capacities, any right, title or interest in and to any of the Product Intellectual Property. Any executed agreements obtained by Seller in connection with Seller’s actions under Sections
3.10(h)(i) and (ii), shall be retained by Seller for a period of ten (10) years following the Closing Date, unless Seller gives Purchaser notice of its intention to destroy any such executed agreements and affords Purchaser a
reasonable opportunity to take possession or make copies thereof. 
 (i) Neither Seller nor any of its Affiliates has licensed, granted,
conveyed, transferred or assigned to any Third Party any right, title or interest in and to the Product, any of the Product Intellectual Property and/or the Product Business. 

Section 3.11 Product Records. All Product Records have been made available by Seller to Purchaser for examination and
copying, and all Product Records are complete and correct in all material respects and have been maintained in accordance with reasonable industry standards. 

Section 3.12 Brokers, Finders, etc. Other than Locust Walk Partners, whose fees, commission and expenses are the sole
responsibility of Seller, Seller has not employed any broker, finder, consultant or other intermediary in connection with the transactions contemplated by the Transaction Documents who would have a valid claim for a fee or commission from Purchaser
in connection with such transactions by reason of any action taken by or on behalf of Seller. 

  
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 Section 3.13 Financial Statements. 

(a) Each form, report, schedule and document required to be filed by Seller under the Securities Exchange Act of 1934, as amended (the
“Exchange Act”) since January 1, 2010 (collectively, the “Seller SEC Filings” and individually, a “Seller SEC Filing”), solely with respect to the Product Business, (i) did, as of its
date, comply in all material respects with the requirements of the Exchange Act and (ii) did not, at the time it was filed, contain any untrue statement of a material fact or omit to state a material fact required to be stated therein or
necessary in order to make the statements made therein, in the light of the circumstances under which they were made, not misleading. 
 (b)
Each of the consolidated financial statements (including in each case, any notes thereto) contained in any Seller SEC Filing, solely to the extent each relates to the Product Business, (i) was prepared in accordance with GAAP applied (except as
may be indicated in the notes thereto and, in the case of unaudited quarterly financial statements, as permitted by Form 10-Q under the Exchange Act) on a consistent basis throughout the periods indicated, and (ii) presented fairly the
consolidated financial position, results of operations and cash flows of Seller as of the respective dates thereof and for the respective periods indicated therein (subject, in the case of unaudited statements, to normal and recurring year-end
adjustments which did not result in a Material Adverse Effect). 
 (c) Seller has previously furnished to Purchaser or has identified to
Purchaser and provided Purchaser an opportunity to confirm or review, (i) (A) sales of the Product for the three-year period ended December 31, 2011, (B) representative returns and allowances pertaining to the Product for the
three-year period ended December 31, 2011, (C) gross and net sales data and cost of goods to Seller for the three-year period ended December 31, 2011 (collectively, the “Financial Data”). The summary of the
Financial Data delivered to Purchaser under the file named PASO Finance Template (Q1 2012).xlsx, a copy of which is attached as Section 3.13(c) of the Seller Disclosure Schedule, was prepared by Seller in good faith from the Product
Records, and fairly present, in all material respects, the financial condition and results of operations of the Product Business as of the date thereof and for the periods shown. To the Knowledge of Seller, the Financial Data furnished by Seller to
Purchaser does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the facts disclosed therein not materially misleading in light of the circumstances in which disclosed. 

Section 3.14 Insurance. There are no material claims currently made against any of the insurance policies of Seller
relating to the Product, the Product Business, no material impairment of the amounts of coverage required thereunder, and Seller has no Knowledge of any reasonable basis for any such claims. 

Section 3.15 Regulatory Compliance. To the extent applicable to the Product in the Territory: 

(a) To the Knowledge of Seller, the Product has been developed, labeled, stored, tested and distributed in compliance with all applicable
requirements under the Federal Food Drug and Cosmetic Act 21 U.S.C. §§301 et. seq., its implementing regulations, and all similar Applicable Laws, including those relating to investigational use, premarket clearance and

  
 25 

 
applications or abbreviated applications to market a new product, except for noncompliance which individually or in the aggregate would not reasonably be expected to have a Material Adverse
Effect. 
 (b) To the Knowledge of Seller, all pre-clinical and clinical investigations conducted by or on behalf of Seller with respect to
the Product have been, and are being, conducted in compliance with all applicable recommendations, policy, and guidance issued by the FDA, 21 C.F.R. Parts 50, 54, 56, 58 and 312 and all other Applicable Laws, including those with respect to good
laboratory practices, investigational new drug requirements, good clinical practice requirements (including informed consent and institutional review boards designed to ensure the protection of the rights and welfare of human subjects), and federal
and state laws restricting the use and disclosure of protected health information, including but not limited to Health Information Technology for Economic and Clinical Health (“HITECH”), the Health Institute Portability and
Accountability Act (“HIPAA”), and regulations related to HITECH and HIPAA, except for noncompliance which individually or in the aggregate would not reasonably be expected to have a Material Adverse Effect. 

(c) To the Knowledge of Seller, with respect to the Product (i) all manufacturing operations conducted for the benefit of Seller have been
and are being conducted in compliance with the FDA’s current Good Manufacturing Practice regulations for drug products, including 21 C.F.R. Parts 210 and 211, and all similar Applicable Laws, except for noncompliance which, individually or in
the aggregate, would not have, or be reasonably likely to have, a Material Adverse Effect; and (ii) Seller is in compliance with all registration and listing requirements set forth in 21 U.S.C. §360 and 21 C.F.R. Part 207, and all similar
Applicable Laws, except for noncompliance which individually or in the aggregate would not reasonably be expected to have a Material Adverse Effect. 

(d) Since the date of acquisition of the Product (or rights thereto) by Seller, the Product has not been recalled, suspended or discontinued as
a result of any action by the FDA or any other foreign Governmental Authority within the Territory, by Seller or by any licensee, distributor or marketer of the Product, within the Territory, or, to the Knowledge of Seller, outside of the Territory.

 (e) Seller has not received any notice or other communication from the FDA or any other Governmental Authority alleging any violation of
any Law applicable to any activity relating to the Product Business that is subject to the jurisdiction of FDA or any other Governmental Authority, nor has any Governmental Authority commenced, or threatened to initiate, any action to enjoin or
place restrictions on the production of the Product. 
 (f) To the Knowledge of Seller, there are no facts, circumstances or conditions that
would be sufficient to presently, or solely with the passage of time in the ordinary course of business, provide a reasonable basis for a recall, suspension or discontinuance of the Product. 

(g) Seller is in compliance with 21 U.S.C. §355, 42 U.S.C. §262 and applicable FDA implementing regulations, including 21 C.F.R.
Parts 312, 314, 600 and 601 and all similar Applicable Laws, and all terms and conditions of the applicable new drug application, biologic license application and investigational new drug exemption submission under 21 U.S.C. §355(i),

  
 26 

 
except for any such failure or failures to be in compliance which individually or in the aggregate has not had and would not reasonably be expected to have a Material Adverse Effect. As to the
Product, Seller and its officers, employees or agents have included in each applicable application, where required, the certification described in 21 U.S.C. §335a(k)(l) and each such certification was true, complete and correct in all material
respects when made. 
 (h) With respect of the Product or of the Product Business, Seller has not committed any act, made any statement or
failed to make any statement that would reasonably be expected to provide a basis for the FDA to invoke its policy respecting “Fraud, Untrue Statements of Material Facts, Bribery, and Illegal Gratuities” set forth in 56 Fed. Reg. 46191
(September 10, 1991) and any amendments thereto, or any similar policy. Neither the Seller nor any of its officers, employees or agents has been convicted of any crime or engaged in any conduct with respect to the Product Business for which
debarment is mandated by 21 U.S.C. §335a(a) or any similar Law or authorized by 21 U.S.C. §335a(b) or any similar Law. 
 (i)
Seller has delivered to Purchaser or made available to Purchaser copies of all annual safety update reports prepared by Seller with respect to the Product. 

Section 3.16 No Other Warranties. Except as expressly provided in the Transaction Documents, Seller does not make any
representation or warranty about the Product, the Purchased Assets the Assumed Liabilities or the Product Business, whatsoever. WITHOUT LIMITING THE FOREGOING, PURCHASER ACKNOWLEDGES THAT, EXCEPT AS EXPRESSLY PROVIDED IN THE TRANSACTION DOCUMENTS,
(A) THE PURCHASED ASSETS ARE BEING TRANSFERRED “AS IS,” (B) SELLER MAKES NO REPRESENTATION OR WARRANTY OF ANY KIND OR AS BY OPERATION OF LAW, BY STATUTE OR OTHERWISE, AND (C) SELLER SPECIFICALLY DISCLAIMS ANY AND ALL IMPLIED
OR STATUTORY WARRANTIES, INCLUDING ANY WARRANTY OF MERCHANTABILITY, WARRANT OF FITNESS FOR A PARTICULAR PURPOSE OR WARRANTY OF NONINFRINGEMENT. 

ARTICLE IV 

REPRESENTATIONS AND WARRANTIES OF PURCHASER 

Purchaser, Parent and Opco, jointly and severally, hereby represent and warrant to Seller as follows. 

Section 4.1 Organization and Authority. Purchaser is a company incorporated under the laws of Ireland. Parent is a limited
liability company duly organized, validly existing and in good standing under the laws of Delaware. Opco is a company incorporated under the laws of Ireland. Each of Purchaser, Parent and Opco has all requisite corporate or limited liability
company, as applicable, power and authority to execute and deliver the Transaction Documents, and the transactions contemplated thereby, and effect the transactions contemplated thereby and has duly authorized the execution, delivery and performance
of the Transaction Documents and transactions or documents contemplated thereby by all necessary corporate or limited liability company, as applicable, action. Each of Purchaser, Parent and Opco has all requisite corporate or limited liability
company, as applicable, power and authority necessary to carry on its business as is currently being conducted. The Transaction Documents will be upon 

  
 27 

 
the Closing, the valid and legally binding obligations of each of Purchaser, Parent and Opco, enforceable against them in accordance with their terms, subject to applicable bankruptcy
moratorium, reorganization, insolvency and similar laws of general application relating to or affecting the rights and remedies of creditors generally and to general equitable principles (regardless of whether in equity or at law). 

Section 4.2 Consents; No Violations. 

(a) Except for the requisite filings under the HSR Act, if any, and the expiration or termination of the waiting period thereunder, and except
for all filings and other actions contemplated by the Transaction Documents (including the necessary transfer of filings, notices and approvals required to transfer the Regulatory Approvals from Seller to Purchaser), the execution, delivery and
performance by each of Purchaser, Parent and Opco of the Transaction Documents and the consummation by Purchaser, Parent and Opco of the transactions contemplated thereby will not require any notice to, filing with, or the consent, approval or
authorization of, any Person or Governmental Authority. 
 (b) Neither the execution and delivery of the Transaction Documents nor the
consummation of the transactions contemplated thereby will (i) violate or result in a breach or result in the acceleration or termination of, or the creation in any Third Party of the right to accelerate, terminate, modify or cancel, any
indenture, contract, lease, sublease, loan agreement, note or other obligation or liability to which Purchaser, Parent or Opco is a party or is bound, (ii) conflict with, violate or result in a breach of any provision of the organizational
documents of Purchaser, Parent or Opco, or (iii) conflict with or violate in any material respect Applicable Law. 

Section 4.3 Brokers, Finders, etc. Purchaser, Parent, Opco and their respective Affiliates have not employed any broker,
finder, consultant or other intermediary in connection with the transactions contemplated by this Agreement and the Ancillary Agreements who would have a valid claim for a fee or commission from Seller in connection with such transactions by reason
of any action taken by or on behalf of Purchaser, Parent or Opco. 
 Section 4.4 Financing. Purchaser and Parent
will collectively have funds sufficient to pay (i) the Closing Cash Payment on the Closing Date and (iii) the Earnouts, if and when applicable. 

Section 4.5 Litigation. There are no lawsuits, claims or any civil, administrative or criminal actions, suits, or
proceedings or governmental investigations existing, pending, or to the Knowledge of Purchaser, threatened, with respect to this Agreement or the transactions contemplated hereby. None of Purchaser, Parent or Opco is subject to any decree or order
of any Governmental Authority that would impair or delay its ability to perform its obligations under this Agreement or the Ancillary Agreements. 

  
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 ARTICLE V 

COVENANTS OF SELLER PRIOR TO CLOSING 

Section 5.1 Conduct of the Product Business Prior to Closing. 

(a) Subject to Applicable Law or as contemplated by this Agreement or consented to in writing by the Purchaser, Seller shall, consistent with
its conduct of the Product Business during the twelve (12) months prior to the Agreement Date: (i) continue and conduct the Product Business in Seller’s ordinary and usual course of business, (ii) preserve intact the market for
the Product and the goodwill associated with the Product and the Product Intellectual Property, (iii) preserve in full force and effect, and, other than in the ordinary course of business, not amend or alter, any material Contracts and/or any
Assumed Contract, (iv) alter its marketing practices in respect of the Product in a manner intended to increase sales of Product prior to Closing, including the offering of incentives which are inconsistent with past practices, (v) sell
the Product only in the ordinary course of business and at levels consistent with past practices for comparable periods of time and (vi) continue to maintain its relationships with suppliers, distributors, customers and others having material
business relationships with it related to the Product Business. 
 (b) Between the Agreement Date and the Closing, Seller shall not take any
affirmative action which would reasonably be expected to (i) cause Seller to violate Section 5.1(a), or (ii) have a Material Adverse Effect on the Product Business, or with, respect to (i) or (ii), refrain from taking any
action which would be reasonably be expected to prevent such an event. 
 Section 5.2 Notice of Default. Between the
Agreement Date and the Closing, Seller shall promptly notify Purchaser in writing if Seller becomes aware of any fact or condition that constitutes a breach of a representation, warranty or covenant of Seller under this Agreement. Any such notice or
disclosure shall not be deemed to amend or supplement Seller’s disclosure under Article III or any schedule hereto, or to correct or cure any misrepresentation, breach of warranty or breach of covenant. 

Section 5.3 No Negotiation. Seller shall not, and shall direct its representatives not to, directly or indirectly,
initiate, solicit or knowingly encourage any Acquisition Proposal, or furnish any information to any other Person with respect to, or agree to or otherwise enter into, any Acquisition Proposal. Seller shall promptly notify Purchaser after
receipt of any Acquisition Proposal or any request for information relating to the Purchased Assets or the Product Business by any Person who has informed Seller or any of its representatives that such Person is considering making, or has made, an
Acquisition Proposal (which notice shall identify the Person making, or considering making, such Acquisition Proposal and shall set forth the material terms of any Acquisition Proposal received), and Seller shall keep Purchaser informed in
reasonable detail of the terms, status and other pertinent details of any such Acquisition Proposal or request. Seller shall, and shall direct its representatives to, discontinue any solicitation efforts or negotiations with respect to or in
furtherance of any Acquisition Proposal. 
 Section 5.4 Commercially Reasonable Efforts. Seller shall use
commercially reasonable efforts to cause the conditions in Section 7.1 and 7.2 to be satisfied. 

  
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 Section 5.5 Notice of Government Investigations. Between the Agreement Date
and the Closing, Seller shall promptly notify Purchaser in writing if Seller has received any notice from the U.S. Department of Justice, the Office of the Inspector General or any other Governmental Authority that such Governmental Authority has
commenced, threatened or intends to commence any action or investigation with respect to the Product Business. 
 ARTICLE VI

 COVENANTS OF PURCHASER AND PARENT PRIOR TO CLOSING 

Section 6.1 Notice of Default. Between the Agreement Date and the Closing, Purchaser, Parent and Opco shall promptly notify
Seller in writing if Purchaser, Parent or Opco becomes aware of any fact or condition that constitutes a breach of a representation, warranty or covenant of Purchaser, Parent or Opco under this Agreement. Any such notice or disclosure shall not be
deemed to amend or supplement Purchaser’s, Parent’s or Opco’s disclosure under Article IV or any schedule hereto, or to correct or cure any misrepresentation, breach of warranty or breach of covenant. 

Section 6.2 Commercially Reasonable Efforts. Purchaser, Parent and Opco shall use commercially reasonable efforts to cause
the conditions in Section 7.1 and 7.3 to be satisfied. 
 ARTICLE VII 

CLOSING AND TERMINATION 

Section 7.1 Conditions Precedent to Obligations of Parties. The respective obligations of Purchaser, Parent, Opco and
Seller to consummate the transactions contemplated by this Agreement on the Closing Date are subject to the satisfaction or waiver at or prior to the Closing Date of the following conditions: 

(a) No Injunction, etc. No Governmental Authority of competent jurisdiction shall have enacted, issued, promulgated, enforced or entered
any Law which is in effect on the Closing Date which would, and no Proceeding by any Governmental Authority shall have been threatened against any of the Parties or any of the officers or directors of any of them seeking to, prohibit, enjoin or
restrain the consummation of the transactions contemplated by this Agreement to occur on the Closing Date or otherwise making such transactions illegal. 

(b) Regulatory Authorizations. (i) All material consents of Governmental Authorities shall have been obtained and shall be in full
force and effect, and (ii) the waiting period under the HSR Act, if applicable, and other any other applicable Antitrust Regulation shall have expired or been terminated. 

Section 7.2 Conditions Precedent to Purchaser’s Obligations. Purchaser’s obligations to consummate the
transactions contemplated by the Transaction Documents shall be subject to the fulfillment of each of the following additional conditions, any one or more of which may be waived, at Purchaser’s sole discretion, in writing by the Purchaser:

 (a) Representations and Warranties. The representations and warranties of Seller in Article III (i) shall have been
accurate in all material respects on the Agreement date and (ii) shall be accurate in all material respects on the Closing Date as if made on the Closing Date 

  
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(except to the extent that any such representation or warranty is made as of a specified date, in which case such representation or warranty shall be accurate in all material respects as of such
date), and Purchaser shall have received a certificate signed on behalf of Seller by an authorized officer of Seller to such effect. 
 (b)
Performance. Seller shall have performed and complied in all material respects with all covenants contained in this Agreement that are required to be performed or complied with by it on or prior to the Closing. 

(c) FDA. With respect to the Product fermentation failure previously disclosed to the FDA by Seller, the FDA shall have approved in
writing the Prior-Approval Supplement filed with the FDA by Seller on March 9, 2012 and as supplemented on May 10, 2012 (a true and complete copy of which shall have been provided to Purchaser) and the release and sale of the Product under
the B-I Purchase Orders, and Seller shall have delivered such written approval(s) to Purchaser. 
 (d) No Material Adverse Effect.
Since the date of this Agreement, no Material Adverse Effect shall have occurred and be continuing. 
 (e) B-I Supply Agreements.
(i) Purchaser, on behalf of itself and Opco, shall have agreed to accept the B-I Supply Agreement, (ii) Boehringer-Ingelheim shall have waived its right to terminate the B-I Supply Agreement upon or following assignment of such agreement
to Purchaser and (iii) Boehringer-Ingelheim shall have consented in writing to the assignment of the B-I Supply Agreement and Quality Agreement to Opco, each of Sections 7.2(e)(i)-(iii) in the form attached hereto as Exhibit
E. 
 (f) Genentech License. Seller shall have delivered to Purchaser the consent of Genentech Inc. to the assignment of the
Genentech License to Purchaser. 
 (g) Closing Documents. Purchaser shall have received the documents set forth in Sections 2.7(a)
– (i) and any document reasonably requested by Purchaser pursuant to Section 2.7(j) provided that Purchaser shall have made such request for such document no less than ten (10) days prior to the Closing. Such documents
shall have been executed by the parties thereto and shall be in full force and effect. 
 Section 7.3 Conditions Precedent to
Seller’s Obligations. Seller’s obligation to consummate the transactions contemplated hereby shall be subject to the fulfillment of each of the following additional conditions, any one or more of which may be waived, at
Seller’s sole discretion, in writing by Seller: 
 (a) Representations and Warranties. The representations and warranties
of Purchaser, Parent and Opco contained in this Agreement shall have been accurate in all material respects on the date of this Agreement and shall be accurate in all material respects as of the Closing Date as if made on and as of the Closing Date
(except to the extent that any such representation or warranty is made as of a specified date, in which case such representation or warranty shall be accurate in all material respects as of such date, except for such inaccuracies that, either
individually or in the aggregate, have not had a material adverse effect on Purchaser, Parent or Opco, as applicable, and Seller shall have received a certificate signed on behalf of each of 

  
 31 

 
Purchaser, Parent and Opco by an authorized officer of Purchaser, Parent and Opco, as applicable, to such effect). 

(b) Performance. Purchaser, Parent and Opco shall each have performed and complied in all material respects with all covenants contained
in this Agreement that are required to be performed or complied with by them on or prior to the Closing, and Seller shall have received a certificate signed on behalf of each of Purchaser, Parent and Opco by an authorized officer of Purchaser,
Parent and Opco, as applicable, to such effect. 
 (c) Closing Documents. Purchaser shall have executed and delivered to Seller the
documents set forth in Sections 2.6(a) – (g) and any document reasonably requested by Seller pursuant to Section 2.6(h) provided that Seller shall have made such request for such document no less than ten (10) days
prior to the Closing, and each such agreement and document shall be in full force and effect. 
 Section 7.4
Termination. This Agreement may be terminated: 
 (a) at any time before the Closing Date by mutual written consent of
Purchaser, Parent, Opco and Seller; or 
 (b) by Purchaser, Parent, Opco or Seller, in writing, if the transactions contemplated hereby have
not been consummated on or before October 31, 2012 (as such date may be extended pursuant to Section 10.6), provided that such failure is not due to the failure of the Party seeking to terminate this Agreement to comply in all
material respects with its obligations under this Agreement, including the failure of the Party seeking to terminate this Agreement to satisfy its closing conditions set forth in this Article VII. 

Section 7.5 Procedure and Effect of Termination. Upon termination of this Agreement by Purchaser, Parent, Opco or Seller
pursuant to Section 7.4, written notice thereof shall forthwith be given to the other Parties and this Agreement shall terminate and the transactions contemplated hereby shall be abandoned without further action by any of the Parties.
Termination of this Agreement shall terminate all outstanding obligations and liabilities between the Parties arising from this Agreement except those described in: (i) this Section 7.5, ARTICLE IX, and
Section 10.1; (ii) the Confidentiality Agreement; and (iii) any other provisions of this Agreement which by their nature are intended to survive any such termination. 

ARTICLE VIII 
 CERTAIN
OTHER COVENANTS 
 Section 8.1 Necessary Efforts; No Inconsistent Action. 

(a) Subject to the other terms and conditions of this Agreement, including the conditions set forth in Article VII, the Parties shall,
and shall cause their respective Affiliates to, use their respective commercially reasonable efforts to take, or cause to be taken, all actions and to do, or cause to be done, all things necessary, proper or advisable under Applicable Law to
consummate and make effective the transactions contemplated by the Transaction Documents and to use their respective commercially reasonable efforts to cause the conditions to each Party’s obligation to close the transactions contemplated
hereby as set forth in Article VII to be 

  
 32 

 
satisfied, including all actions necessary to obtain all Consents and all waivers or terminations of applicable waiting periods required for the satisfaction of the conditions set forth in
Section 7.1(b), and all other Consents necessary in connection with the consummation of the transactions contemplated by the Ancillary Agreements; provided, however, that the foregoing provisions of this Section 8.1(a) shall
not (i) require any Party to perform, satisfy or discharge any obligations of any other Party under this Agreement or otherwise or (ii) subject to the provisions of Section 2.9, require any Party or its Affiliates to expend any
money other than for filing fees or expenses or de minimus costs or expenses or agree to any restrictions in order to obtain any Consents. The Parties shall cooperate fully with each other to the extent necessary in connection with the foregoing.

 (b) In connection with the efforts referenced in Section 8.1(a), the Parties shall timely and promptly make all filings which
may be required for the satisfaction of the condition set forth in Section 7.1(b) by each of them in connection with the consummation of the transactions contemplated hereby. In furtherance and not in limitation of the foregoing, if
required under Applicable Law, each Party shall file, or cause to be filed, Notification and Report Forms under the Hart Scott Rodino Antitrust Improvements Act of 1976, as amended (the “HSR Act”), or any other similar filings under
Antitrust Regulations of any other Governmental Authority as promptly as practicable following the date of this Agreement and in any event no later than (i) ten (10) Business Days following the date of this Agreement, in the case of
Notification and Report Forms under the HSR Act, and (ii) the time prescribed by Applicable Law in the case of requirements under other applicable Antitrust Regulations to the extent a time is prescribed and, if no time is prescribed, as
promptly as reasonably practicable. In addition, the Parties shall, and shall cause their respective Affiliates to, cooperate and use their commercially reasonable efforts and take all actions necessary to (A) respond as promptly as practicable
to any requests for information from any Governmental Authority, and to avoid and/or overcome any action, including any legislative, administrative or judicial action, and (B) have vacated, lifted, reversed or overturned any judgment,
injunction or other order (whether temporary, preliminary or permanent) that restricts, prevents or prohibits, or could restrict, prevent or prohibit, the consummation of the transactions contemplated by this Agreement; provided, however, that in no
event shall Seller or any of its Affiliates be required or expected to retain any of the Purchased Assets in order to comply with its obligations in respect of the foregoing. Each Party shall furnish to the other such necessary information and
assistance as the other Party may reasonably request in connection with the preparation of any necessary filings or submissions by it to any Governmental Authority. Except as prohibited or restricted by Applicable Law or any Antitrust Regulations,
each Party or its attorneys shall provide the other Party or its attorneys the opportunity to make copies of all correspondence, filings or communications (or memoranda setting forth the substance thereof) between such Party or its representatives,
on the one hand, and any Governmental Authority, on the other hand, with respect to the Transaction Documents or the transactions contemplated thereby, subject to redaction as reasonably necessary of documents filed pursuant to Item 4(c) of the
Hart Scott Rodino Notification and Report Form. Without in any way limiting the foregoing, the Parties shall consult and cooperate with one another, and consider in good faith the views of one another, in connection with any analyses, appearances,
presentations, memoranda, briefs, arguments, opinions and proposals made or submitted by or on behalf of any Party in connection with proceedings under or relating to the HSR Act or any other Antitrust Regulation. 

  
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 Section 8.2 Public Disclosures. Unless otherwise required by Applicable Law,
the rules and regulations of any stock exchange or quotation services on which such Party’s stock is traded or quoted, prior to the Closing Date, no news release or other public announcement pertaining to the transactions contemplated by this
Agreement will be made by or on behalf of a Party or its Affiliates without the prior written approval of the other Party (which approval shall not be unreasonably withheld, conditioned or delayed). If in the judgment of any Party such a news
release or public announcement is required by Applicable Law or the rules or regulations of any stock exchange on which such Party’s stock is traded, the Party intending to make such release or announcement shall to the extent practicable use
commercially reasonable efforts to provide prior written notice to the other Party of the contents of such release or announcement and to allow the other Party reasonable time to comment on such release or announcement in advance of such
issuance. 
 Section 8.3 Product Returns, Rebates and Chargebacks. Product Returns, Commercial Rebates and
Chargebacks are to be processed by the Parties in accordance with the provisions of the Transition Services Agreement. 

Section 8.4 Transitional Trademark License. 

(a) As of the Closing Date and for a period of up to twenty-four months (24) months after the Closing Date, Seller hereby grants to
Purchaser (or its Affiliates responsible for operating the Product Business after Closing or any Third Party manufacturers utilized by Purchaser in connection with the Product Business after the Closing Date), and Purchaser hereby accepts, a
non-exclusive, non-transferable, non-sublicensable (except with respect to such Third Party manufacturers or Purchaser’s Affiliates), royalty-free, paid-up, license in the Territory under the Seller Marks, for use solely in connection with
(i) Purchaser’s sale of the Inventory in the Territory, and (ii) Purchaser’s use of the Promotional Materials existing as of the Closing Date and transferred to Purchaser as part of the Purchased Assets, and (iii) the
labeling on the Product manufactured by or on behalf of Purchaser as of and after the Closing; provided, however, that such license is being granted solely for transitional purposes and Purchaser shall therefore, notwithstanding the time period
provided for above, use its commercially reasonable efforts to as quickly as is reasonably possible cease its use of the Seller Marks after the Closing, but in no event later than twenty-four (24) months after the Closing Date, or such later
date (not to exceed an additional six (6) months) upon consent by Seller, such consent not be unreasonably withheld. 
 (b) To the
extent that Purchaser is utilizing the transitional trademark license set forth in Section 8.4(a), Purchaser shall not (i) add any marks to, or otherwise alter, the Seller Marks as used in the Product Business as of the Closing Date
(except as required by Applicable Law); (ii) change in any way the style of the Seller Marks as used in the Product Business as of the Closing Date; or (iii) otherwise use the Seller Marks in any manner other than as specifically provided
in this Section 8.4. 
 (c) Purchaser acknowledges Seller’s ownership of the Seller Marks, shall do nothing inconsistent
with such ownership, and agrees not to challenge Seller’s title to the Seller Marks. Nothing in this Agreement shall give Purchaser any right, title or interest in the Seller Marks other than the right to use the Seller Marks strictly in
accordance with this Section 8.4. All use 

  
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of the Seller Marks by Purchaser under this Section 8.4 shall conform to the standards followed by Seller in operating the Product Business prior to the Closing Date, and Seller shall
have the right to review the standards used by Purchaser to operate the Product Business after the Closing Date to ensure Purchaser’s compliance with this requirement related to the Seller Marks. 

(d) Purchaser shall not have the right to, and shall not, sublicense, assign, pledge, grant or otherwise encumber or transfer to any Third
Party any rights licensed by Seller to Purchaser under Section 8.4(a) without Seller’s prior written consent. The Parties understand and agree that, in addition to all other legal remedies, Seller shall be entitled to immediate
injunctive relief in order to enforce the terms of this Section 8.4. 
 (e) Nothing in this Section 8.4, or any other
provision of this Agreement or any provision of the Ancillary Agreements, shall grant the Purchaser any rights in any of Seller’s Internet domain names, registrations or applications for registration, or renewals thereof, registered in the
United States or any other country or jurisdiction throughout the world, except as such Internet domain names, registrations or applications for registration, or renewals thereof are included as part of the Purchased Assets. 

(f) Following the Closing, Purchaser shall promptly and at its own expense use commercially reasonable efforts to obtain such FDA approvals
necessary for Purchaser Labeling for the Product to be manufactured after the Closing and, promptly comply with such FDA approvals upon receipt thereof. 

Section 8.5 Customer Billing. In the event that Seller or any of its Affiliates receives payment after the Closing Date on
invoices relating to the Product Business operated by the Purchaser or sales of products or services rendered by Purchaser on or after the Closing, Seller will promptly notify Purchaser of such receipt and will promptly remit, or will cause such
Affiliate to promptly remit, such payment to Purchaser without depositing such payment in an account of Seller, or such Affiliate, unless in error, and Seller, or such Affiliate, shall not be entitled to offset such payment against any payments due
Seller from Purchaser. In the event Seller receives an invoice or request for payment relating to the operation of the Product Business on or after the Closing Date, or with respect to any Assumed Liability, Seller will promptly notify Purchaser of
such request or invoice and forward the invoice and all other appropriate information to Purchaser for payment. In the event Purchaser or any of its Affiliates receive payment after the Closing Date on invoices issued by Seller relating to an
Excluded Asset (such as Seller’s accounts receivable as of the Closing Date) or relating to product sold or services rendered by businesses other than the Product Business or the Purchased Assets, Purchaser will promptly notify Seller of such
receipt and will promptly remit, or will cause such Affiliate to promptly remit, such payment to Seller without depositing such payment in an account of Purchaser, or such Affiliate, unless in error, and Purchaser, or such Affiliate, shall not be
entitled to offset such payment against any payments due Purchaser from Seller. 
 Section 8.6 Cooperation.

 (a) After the Agreement Date, the Parties shall cooperate reasonably with each other in connection with any reasonable actions
required to be taken with respect to their respective obligations under this Agreement and the Ancillary Agreements, and shall (i) furnish upon 

  
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reasonable request to each other such further information, and (ii) execute and deliver to each other such other reasonable documents, and (iii) do such other acts, all as the other
Party may reasonably request for the purpose of carrying out the provisions of this Agreement (and the Ancillary Agreements) and the transactions contemplated hereby and thereby. 

(b) The Parties will promptly notify each other in writing, of any event or fact which represents a material breach of any of their respective
representations, warranties, covenants or agreements hereunder. 
 Section 8.7 Reserved. 

Section 8.8 Tax Matters. 

(a) Seller and Purchaser shall provide reasonable cooperation and information to each other in connection with (i) the preparation or
filing of any Tax Return, Tax election, Tax consent or certification, or any claim for a Tax refund, (ii) any determination of liability for Taxes and (iii) any audit, examination or other proceeding in respect of Taxes related to the
Product Business. Seller and Purchaser shall make themselves (and their respective employees) reasonably available on a mutually convenient basis to provide an explanation of any documents or information provided under this
Section 8.8(a). Each of Seller and Purchaser shall retain all Tax Returns, work papers and all material records or other documents in its possession (or in the possession of its Affiliates) relating to Tax matters of the Product Business
for any taxable period that includes the Closing Date and for all prior taxable periods until the later of (i) the expiration of the statute of limitations of the taxable period to which such Tax Returns and other documents relate, without
regard to extensions, or (ii) six (6) years following the due date (without extension) for such Tax Returns. Prior to the expiration of such time, if Seller or Purchaser desire to retain any such documents in the other’s possession
(or in the possession of the other party’s Affiliates), such party desiring to retain such document shall give notice to the other party at least ninety (90) days’ prior to the later of (i) the expiration of the statute of
limitations of the taxable period to which such Tax Returns and other documents relate, without regard to extensions, or (ii) six (6) years following the due date (without extension) for such Tax Returns, requesting that such other party
remove and retain all or any part of the such documents (at such party’s request). Any information obtained under this Section 8.8(a) shall be kept confidential pursuant to Section 10.1, except as may be otherwise
necessary in connection with the filing of Tax Returns, claims for a Tax refund or in conducting any audit, examination or other proceeding in respect of Taxes. 

(b) Purchaser and Seller shall each be responsible for fifty percent (50%) of all sales, use, transfer, value added and other similar
Taxes (the “Transfer Taxes”), if any, arising out of the transfer by Seller of the Purchased Assets to Purchaser pursuant to this Agreement; provided that, Seller shall have no responsibility for, and Purchaser will be solely
responsible for, any value added Tax payable in connection with the sale, assignment, transfer, conveyance and delivery to Purchaser of the Inventory identified on Schedule 1.1(a) and the Product under the BI Purchase Orders pursuant to
Section 2.1(c). 
 (c) All real property, personal property and similar ad valorem Taxes (collectively, “Property
Taxes”) levied with respect to the Purchased Assets for the Tax period in which the 

  
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Closing Date occurs (a “Straddle Period”) shall be apportioned between Purchaser and Seller based on the number of days of such Straddle Period included in the portion of
such period ending on the Closing Date (the “Pre-Closing Tax Period”) and the number of days of such Straddle Period included in the portion of such period beginning after the Closing Date (the “Post-Closing Tax
Period”). Seller shall be liable for the proportionate amount of such Property Taxes that is attributable to the Pre-Closing Tax Period, and Purchaser shall be liable for the proportionate amount of such Property Taxes that is attributable
to the Post-Closing Tax Period. Upon receipt of any bill for such Property Taxes, Purchaser or Seller, as applicable, shall present a statement to the other setting forth the amount of reimbursement to which each is entitled under this
Section 8.8(c) together with such supporting evidence as is reasonably necessary to calculate the proration amount. The proration amount shall be paid by the party owing it to the other within ten (10) days after delivery of such
statement. 
 (d) Purchaser and Seller agree and acknowledge that no withholding of Taxes is required under Irish or other Applicable Law
with respect to any of the payments contemplated by Section 2.1 and that no payments under Section 2.1 shall be reduced by any withholding Taxes. 

Section 8.9 Notice to Customers. Seller agrees to cooperate with Purchaser, at Purchaser’s reasonable request, in the
notification to customers of the transactions contemplated by this Agreement and Seller agrees not to notify any customer of such transactions without the consent of Purchaser. Such notification shall be in such form as is reasonably satisfactory to
both Purchaser and Seller as agreed to prior to Closing. 
 Section 8.10 Adverse Experience Reports. At a mutually agreed
upon time after the Closing, Seller shall provide Purchaser with information relating to the investigation and reporting of all adverse experiences regarding the Product prior to the Closing and all other information which is
materially relevant to the safe use of the Product in Seller’s possession as of the Closing. After the Closing, Seller shall promptly submit to Purchaser all adverse drug experience information or customer complaints brought to the attention of
Seller in respect of the Product, as well as any material events and matters concerning or affecting the safety or efficacy of the Product. After the Closing and after the time the appropriate Governmental Authorities are notified of the transfer of
the applicable Regulatory Approvals, Purchaser shall have all responsibility for required reporting of adverse experiences for the Product. 

Section 8.11 Regulatory Matters. 

(a) Except as expressly set forth in Section 8.10 or the Transition Services Agreement, from and after the Closing, Purchaser, at
its cost, shall be solely responsible and liable for (i) taking all actions, paying all fees and conducting all communication with the appropriate Governmental Authority required by Applicable Law in respect of the Regulatory Approvals,
including preparing and filing all reports (including adverse drug experience reports) with the appropriate Governmental or Regulatory Authority (whether the Product is sold before or after transfer of such Regulatory Approval), (ii) taking all
actions and conducting all communication with third parties in respect of the Product sold pursuant to such Regulatory Approval (whether sold before or after transfer of such Regulatory Approval), including responding to all complaints in respect
thereof, including complaints related to tampering or 

  
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contamination, and (iii) investigating all complaints and adverse drug experiences in respect of the Product sold pursuant to such Regulatory Approval (whether sold before or after transfer
of such Regulatory Approval). 
 (b) From and after the Closing, and subject to Section 8.10 hereof and the Transition Services
Agreement, Seller promptly (and in any event within the time periods required by Applicable Law) shall notify Purchaser within three (3) Business Days if Seller receives a complaint or a report of an adverse drug experience in respect of the
Product. In addition, Seller shall cooperate with Purchaser’s reasonable requests and use commercially reasonable efforts to assist Purchaser in connection with the investigation of and response to any complaint or adverse drug experience
related to the Product sold by Seller. 
 (c) From and after the Closing, Purchaser, at its cost, shall be solely responsible and liable for
conducting all voluntary and involuntary recalls of units of the Product sold pursuant to such Regulatory Approval (whether sold before or after transfer of such Regulatory Approval), including recalls required by any Governmental Authority and
recalls of units of the Product sold by Seller deemed necessary by Seller in its reasonable discretion; provided, however, that Seller shall reimburse Purchaser for the reasonable expenses and costs of conducting recalls relating to Product sold by
or on behalf of Seller prior to the Closing, including the costs of notifying customers, the costs associated with shipment of such recalled Product, the price paid for such Inventory, and reasonable credits extended to customers in connection with
the recall. Seller shall notify Purchaser promptly in the event that a recall of the Product sold by Seller is necessary. 
 (d) Seller
shall, within fifteen (15) days after the Closing, notify the FDA of the transfer of the Regulatory Approvals to Purchaser in accordance with all Applicable Laws. 

Section 8.12 Product Records. At the Closing, or as soon as possible thereafter, Seller shall transfer to Purchaser, to the
extent in Seller’s actual possession, the original copies of the Product Records and Assumed Contracts. Seller may retain one (1) archival copy of the Product Records and Assumed Contracts solely for archival purposes or as required by
Applicable Law. Prior to delivering or making available any Product Records to Purchaser, Seller shall be entitled to redact therefrom any information that does not relate to the Product Business. 

Section 8.13 Employees. The Parties acknowledge and agree that there is no intent or agreement that any employee of Seller
will terminate his or her employment with Seller and/or commence employment with Purchaser as a result of the transactions contemplated by this Agreement. 

Section 8.14 Non-Competition. 

(a) Seller hereby covenants and agrees that, for a period of five (5) years from the Closing Date, neither Seller nor any of its
Affiliates (either alone or in collaboration with any Third Party) shall (i) make, use, develop, promote, advertise, market, distribute, sell, offer to sell, import, export and/or commercialize the Product and/or any Competing Product, for any
use, purpose, indication or treatment (whether for the treatment of idiopathic pulmonary fibrosis, or any other disease or disorder), anywhere in the Territory or elsewhere in the world, (ii) engage in

  
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any aspect of the Product Business, (iii) file any applications for regulatory approval, including new drug applications, abbreviated new drug applications, new drug submissions, and any
comparable applications and submissions, with any Governmental Authority in the Territory or elsewhere in the world, with respect to the Product and/or any Competing Product, for any use, purpose, indication or treatment (whether for the treatment
of idiopathic pulmonary fibrosis, or any other disease or disorder) and/or (iv) use any of the Excluded Assets or IPF Patient Data to engage in any conduct prohibited under Sections 8.14(a)(i)-(iii); provided that this
Section 8.14(a) shall not apply to non-affiliated successors or assigns of Seller. 
 (b) Purchaser, Parent and Opco hereby
covenant and agree that, for a period of five (5) years from the Closing Date, neither Purchaser, Parent, Opco nor any of their respective Affiliates (either alone or in collaboration with any Third Party) shall (i) make, use, develop,
promote, advertise, market, distribute, sell, offer to sell, import, export and/or commercialize the Product for the treatment of idiopathic pulmonary fibrosis, anywhere in the Territory or elsewhere in the world, and/or (ii) file any
applications for regulatory approval, including new drug applications, abbreviated new drug applications, new drug submissions, and any comparable applications and submission, with any Governmental Authority in the world, with respect to the Product
for the treatment of idiopathic pulmonary fibrosis. For clarity, except as set forth in Section 2.10, nothing in this Section 8.14 or in the Transaction Documents shall operate or be construed to prevent, limit, restrict or
impair Purchaser’s right to, for example but without limitation, (1) make, use, develop, promote, advertise, market, distribute, sell, offer to sell, import, export and/or commercialize the Product for any use, purpose, indication or
treatment (other than for the treatment of idiopathic pulmonary fibrosis), anywhere in the Territory or elsewhere in the world, in each case, whether alone, or as a mixture or in combination with any variation(s) or any analog polypeptide(s) of the
Product and/or with any other biologic(s), product(s) or composition(s), (2) file any applications for regulatory approval, including new drug applications, abbreviated new drug applications, new drug submissions, and any comparable
applications and submissions, with any Governmental Authority in the Territory or elsewhere in the world, with respect to the Product for any use, purpose, indication or treatment (other than for the treatment of idiopathic pulmonary fibrosis), in
each case, whether alone, or as a mixture or in combination with any variation(s) or any analog polypeptide(s) of the Product and/or with any other biologic(s), product(s) or composition(s), and/or (3) use the Product and/or any of the Product
Intellectual Property to develop improvements or enhancements to the Product for purposes of engaging in any of the conduct described in this Section 8.14(b)(1)-(2); provided that this Section 8.14(b) shall not apply to
non-affiliated successors or assigns of Purchaser. Seller hereby covenants and agrees that neither Seller nor any of its Affiliates (either alone or in collaboration with any Third Party) shall prevent, limit, restrict or impair any of
Purchaser’s rights set forth in this Section 8.14(b). 
 (c) Nothing in this Section 8.14 or in the Transaction
Documents shall operate or be construed as a waiver, disclaimer, abridgment, abrogation or truncation of any of Purchaser’s, Parent’s, Opco’s and/or any of their respective Affiliates’ rights, titles and/or interests in and to
the Product Intellectual Property and/or in and to any Intellectual Property owned or licensed (as licensor or licensee) by Purchaser, Parent, Opco and/or any of their respective Affiliates. For the avoidance of doubt, nothing in this
Section 8.14 or in the Transaction Documents shall operate or be construed as assigning, conveying, transferring or granting to Seller and/or any of its Affiliates any rights, titles, interests, licenses or authorities in and to any of
the Product 

  
 39 

 
Intellectual Property and/or in and to any Intellectual Property owned or licensed (as licensor or licensee) by Purchaser, Parent, Opco and/or any of their respective Affiliates. 

(d) In order to receive the full benefit of the bargain under the Transaction Documents, the Parties hereto have knowingly and voluntarily
entered into, and intend to be fully and legally bound to, the restrictive covenants of this Section 8.14, including, without limitation, as to the defined territory, duration, and prohibited conduct set forth in this
Section 8.14. 
 Section 8.15 Seller’s Additional Covenants and Agreements. 

(a) Seller hereby covenants and agrees that neither Seller nor any of its Affiliates (either alone or in collaboration with any Third Party)
shall, at any time on or subsequent to the Closing Date, challenge or otherwise contest before any Governmental Authority or via any Proceeding (i) Purchaser’s right, title and interest in and to the Product, the Product Business, and the
Product Intellectual Property, (ii) the validity and/or the enforceability of any of the Product Intellectual Property, (iii) Purchaser’s right to seek and obtain any copyright, patent and/or trademark protection for the Product, the
Product Business, and/or any of the Product Intellectual Property, (iv) the validity and/or the enforceability of any copyright(s), patent(s) and/or trademark(s) so obtained by Purchaser for the Product, the Product Business, and/or any of the
Product Intellectual Property, (v) Purchaser’s right to retain any and all income, revenue, profit, royalties, damages, claims and payments attributable thereto, payable in connection therewith, or otherwise derived therefrom, without any
duty to account to Seller (excepted as otherwise provided under this Agreement), (vi) Purchaser’s right to bring any and all causes of action, either in law or in equity, for past, present or future infringement of any of the Product
Intellectual Property, (vii) Purchaser’s right to exploit the Product Intellectual Property for whatever purposes Purchaser shall elect to pursue, including, without limitation, improvements, combinations and analogies thereof and
commercialization for new uses and indications (other than for the treatment of idiopathic pulmonary fibrosis) or as otherwise restricted by the terms of this Agreement, and (viii) Purchaser’s right to any and all rights, titles and
interests corresponding to the foregoing throughout the world. 
 (b) Seller hereby covenants and agrees that neither Seller nor any of its
Affiliates (either alone or in collaboration with any Third Party) shall, at any time on or subsequent to the Closing Date (i) undertake any action that may damage, diminish, impair or infringe upon, any of Purchaser’s right, title and/or
interest in and to the Product, the Product Business, and/or any of the Product Intellectual Property, (ii) assist any Third Party in challenging or otherwise contesting Purchaser’s rights, titles and interests in and to the Product, the
Product Business and/or any of the Product Intellectual Property, anywhere in the world, (iii) use any of the Product Intellectual Property, and/or (iv) obtain or assert any right(s), title(s) or interest(s) to any patent, trademark or
copyright relating to the Product, the Product Business and/or any of the Product Intellectual Property. 
 (c) To the extent that Seller, at
the time of Closing, has any right, title or interest in Intellectual Property which, subsequent to Closing, Seller reasonably determines would materially prevent, limit, restrict or impair Purchaser’s ability to (i) commercialize the
Product, (ii) engage in the Product Business, (iii) exercise or exploit any of the Product Intellectual 

  
 40 

 
Property, and/or (iv) bring any and all causes of action, either in law or in equity, for past, present or future infringement of any of the Product Intellectual Property, (the
“Additional Intellectual Property”), the Seller shall notify Purchaser of such determination and the Parties will work in good faith to provide Purchaser with the rights to such Additional Intellectual Property solely in the Product
Business. 
 ARTICLE IX 

INDEMNIFICATION 

Section 9.1 Indemnification. 

(a) Subject to the terms and conditions of this Article IX, from and after the Closing, Seller shall indemnify, reimburse, defend and
hold harmless Purchaser, its Affiliates and their respective officers, directors, managers, employees, stockholders, members, agents, successors and assigns (collectively, the “Purchaser Indemnified Parties”) from and against, and
shall compensate and reimburse each Purchaser Indemnified Party, for any and all Losses incurred by such Purchaser Indemnified Party to the extent arising or resulting from: 
  

	 	(i)	any inaccuracy or breach of any representation or warranty of Seller contained in this Agreement; 

  

	 	(ii)	any breach of any covenant or agreement of Seller contained in this Agreement or in any of the Ancillary Agreements; or 

  

	 	(iii)	the failure of Seller or any of its Affiliates to pay, perform or discharge any Excluded Liabilities; or 

  

	 	(iv)	any Third Party claim by a Third Party relating to the conduct of the Product Business by Seller or any of its Affiliates prior to the Closing. 

(b) Subject to the terms and conditions of this Article IX, from and after the Closing, Purchaser, Parent and Opco shall, jointly and
severally, indemnify, reimburse, defend and hold harmless Seller, its Affiliates and their respective officers, directors, managers, employees, stockholders, agents, successors and assigns (collectively, the “Seller Indemnified
Parties”) from and against, and shall compensate and reimburse each Seller Indemnified Party for, any and all Losses incurred by such Seller Indemnified Party to the extent arising or resulting from: 

 

	 	(i)	any inaccuracy or breach of any representation or warranty of Purchaser, Parent or Opco contained in this Agreement; 

  

	 	(ii)	any breach of any covenant or agreement of Purchaser, Parent or Opco contained in this Agreement or in any of the Ancillary Agreements; 

 

	 	(iii)	the failure of Purchaser or any of its Affiliates to pay, perform or discharge any Assumed Liabilities; or 

  

	 	(iv)	 any Third Party Claim by a Third Party relating to the conduct of the Product Business by Purchaser of any of its Affiliates from and after

  
 41 

	 	
Closing, except to the extent such Third Party Claim arises directly out of (1) any inaccuracy or breach of any representation or warranty of Seller contained in this Agreement or in any of
the Ancillary Agreements, or (2) the negligence, recklessness, bad faith, or intentional wrongful acts or omissions of Seller or its Affiliates. 

(c) NOTWITHSTANDING THE FOREGOING, PURCHASER LOSSES AND SELLER LOSSES SHALL NOT INCLUDE, AND IN NO EVENT SHALL ANY PURCHASER LOSSES OR SELLER
LOSSES BE RECOVERABLE UNDER THE TERMS OF THIS AGREEMENT TO THE EXTENT SUCH DAMAGES CONSIST OF PUNITIVE, SPECIAL OR EXEMPLARY DAMAGES, EXCEPT TO THE EXTENT SUCH PUNITIVE, SPECIAL OR EXEMPLARY DAMAGES ARE AWARDED AGAINST ANY PURCHASER INDEMNIFIED
PARTY OR SELLER INDEMNIFIED PARTY, AS THE CASE MAY BE, IN A THIRD-PARTY CLAIM. 
 Section 9.2 Certain Limitations.
Notwithstanding anything to the contrary contained in this Agreement, each of the following limitations shall apply: 
 (a) Seller
will not be required to indemnify Purchaser under Sections 9.1(a)(i) (other than Losses incurred as a result of any inaccuracy or breach of any representation or warranty contained in Sections 3.1 (Organization and Authority),
3.2(b) (Title to Purchased Assets), 3.9 (Tax Matters), 3.12 (Brokers, Finders, etc.), or attributable to fraud or intentional misconduct, as to which this Section 9.2(a) shall not apply), except to the extent that
the cumulative amount of the Losses under Section 9.1(a)(i) incurred by the Purchaser Indemnified Parties exceeds Two Hundred Fifty Thousand Dollars (U.S. $250,000) (the “Basket Amount”) at which point Seller will
be required to pay, and will have Liability for, the cumulative amount of the Losses under Section 9.1(a)(i) incurred by the Purchaser Indemnified Parties. 

(b) Purchaser, Parent and Opco will not be required to indemnify Seller under Section 9.1(b)(i) (other than Losses incurred as a
result of any inaccuracy or breach of any representation or warranty contained in Sections 4.1 (Organization and Authority) or 4.3 (Brokers, Finders, etc.), or attributable to fraud or intentional misconduct, as to which this
Section 9.2(b) shall not apply) except to the extent that the cumulative amount of the Losses under Section 9.1(b)(i) incurred by the Seller Indemnified Parties exceeds the Basket Amount at which point Purchaser, Parent and
Opco, jointly and severally, will be required to pay, and will have Liability for, the cumulative amount of the Losses under Section 9.1(b)(i) incurred by the Seller Indemnified Parties. 

(c) In no event shall the aggregate out-of-pocket Liability of Seller for any Losses pursuant to Sections 9.1(a)(i) exceed Five Million
Five Hundred Thousand Dollars (U.S. $5,500,000) (the “Cap”); provided, that Losses incurred as a result of any inaccuracy or breach of any representation or warranty contained in Section 3.1 (Organization and Authority),
3.2(b) (Title to Purchased Assets), 3.9 (Tax Matters) and 3.12 (Brokers, Finders, etc.) shall not exceed the Purchase Price; provided, further, that the limitations set forth in this Section 9.2(c)
shall not apply to Losses attributable to fraud or intentional misconduct. 

  
 42 

 (d) In no event shall the aggregate out-of-pocket Liability of Purchaser, Parent or Opco for any
Losses pursuant to Sections 9.1(b)(i) (other than Losses incurred as a result of any inaccuracy or breach of any representation or warranty contained in or attributable to fraud or intentional misconduct, as to which this
Section 9.2(d) shall not apply) exceed the Cap; provided, that Losses incurred as a result of any inaccuracy or breach of any representation or warranty contained in Sections 4.1 (Organization and Authority) or 4.3
(Brokers, Finders, etc.) shall not exceed the Purchase Price; provided, further, that the limitations set forth in this Section 9.2(d) shall not apply to Losses attributable to fraud or intentional misconduct. 

(e) In no event shall Seller, Purchaser, Parent or Opco have any Liability under Section 9.1(a)(i), or 9.2(b)(i), as the
case may be, with respect to claims that are not properly asserted in writing prior to the date that is eighteen (18) months after the Closing Date (other than claims for Losses incurred as a result of any inaccuracy or breach of any
representation or warranty attributable to fraud or intentional misconduct, as to which this Section 9.2(e) shall not apply); provided, however, that (i) claims for Losses incurred as a result of any inaccuracy or
breach of any representation or warranty contained in Sections 3.1 (Organization and Authority), 3.2(b) (Title to Purchased Assets), 3.9 (Tax Matters), 3.12 (Brokers, Finders, etc.), 4.1 (Organization and
Authority) or 4.3 (Brokers, Finders, etc.), may be asserted at any time prior to expiration of the applicable statute of limitations and (ii) claims attributable to fraud or intentional misconduct, will have no expiration date. 

(f) The representations and warranties made by each Party in this Agreement shall survive the Closing and shall expire eighteen
(18) months after the Closing Date and any Liability of any Party with respect to such representations and warranties (other than Losses incurred as a result of any inaccuracy or breach of any representation or warranty contained in
(i) Sections 3.1 (Organization and Authority), 3.2(b) (Title to Purchased Assets), 3.9 (Tax Matters), 3.12 (Brokers, Finders, etc.), 4.1 (Organization and Authority) and 4.3 (Brokers, Finders, etc.),
which shall expire upon expiration of the applicable statute of limitations, or (ii) attributable to fraud or intentional misrepresentation, as to which no expiration date shall apply; provided, however, that if, at any time prior
to such expiration date, notice of any case for indemnification pursuant to Section 9.1(a) or Section 9.1(b), as the case may be, shall have been given prior to the applicable expiration date and such notice describes the
circumstances with respect to which such indemnification claim relates, such indemnification claim shall survive until such time as such claim is finally resolved. 

Section 9.3 Procedures for Third Party Claims and Excluded Liabilities. 

(a) General Procedures. Promptly (but in no event later than ten (10) days) after the receipt by any Indemnified Party of a notice
of any Proceeding by any Third Party that may be subject to indemnification under this Article IX, including any Proceeding relating to any Excluded Liability or Assumed Liability, such Indemnified Party shall give written notice of such
Proceeding to the Indemnifying Party, stating in reasonable detail the nature and basis of each claim made in the Proceeding and the amount thereof, to the extent known, along with copies of the relevant documents received by the Indemnified Party
evidencing the Proceeding and the basis for indemnification sought. Failure of the Indemnified Party to give such notice shall not relieve the Indemnifying Party from liability on account of this indemnification, except if and only to the extent
that the Indemnifying Party is actually prejudiced thereby. Thereafter, 

  
 43 

 
the Indemnified Party shall deliver to the Indemnifying Party, promptly after the Indemnified Party’s receipt thereof, copies of all notices and documents (including court papers) received
by the Indemnified Party relating to the Proceeding. The Indemnifying Party shall have the right to assume the defense of the Indemnified Party against the Third Party Claim upon written notice to the Indemnified Party delivered within thirty
(30) days after receipt of the particular notice from the Indemnified Party; provided, however, that the Indemnifying Party shall not have the right to assume the defense of the Third Party Claim if such Third Party Claim (x) seeks as a
remedy the imposition of an equitable remedy that is binding upon Purchaser, Parent or Opco, the Purchased Assets or the Assumed Liabilities or (y) the amounts of Losses would be reasonably expected to exceed the amounts for which the
Indemnifying Party is obligated to indemnify. So long as the Indemnifying Party has assumed the defense of the Third Party Claim in accordance herewith and notified the Indemnified Party in writing thereof, (i) the Indemnified Party may retain
separate co-counsel at its sole cost and expense and participate in the defense of the Third Party Claim, it being understood that the Indemnifying Party shall pay all reasonable costs and expenses of counsel for the Indemnified Party after such
time as the Indemnified Party has notified the Indemnifying Party of such Third Party Claim and prior to such time as the Indemnifying Party has notified the Indemnified Party that it has assumed the defense of such Third Party Claim, (ii) the
Indemnified Party shall not file any papers or consent to the entry of any judgment or enter into any settlement with respect to the Third Party Claim without the prior written consent of the Indemnifying Party (not to be unreasonably withheld,
conditioned or delayed) and (iii) the Indemnifying Party will not consent to the entry of any judgment or enter into any settlement with respect to the Third Party Claim (other than a judgment or settlement that is solely for money damages in
an amount less than the remaining balance of the limitations on indemnity set forth in Section 9.2 and is accompanied by a release of all indemnifiable claims against the Indemnified Party) without the prior written consent of the
Indemnified Party (not to be unreasonably withheld, conditioned or delayed). Whether or not the Indemnifying Party shall have assumed the defense, such Indemnifying Party shall not be obligated to indemnify and hold harmless the Indemnified Party
hereunder for any settlement entered into without the Indemnifying Party’s prior written consent, which consent shall not be unreasonably withheld, conditioned or delayed. 

(b) Equitable Remedies. In the case of any Third Party Claims where the Indemnifying Party reasonably believes that it would be
appropriate to settle such claim using equitable remedies (i.e., remedies involving the future use of the Purchased Assets), the Indemnifying Party and the Indemnified Party shall work together in good faith to agree to a settlement; provided,
however, that no Party shall be under any obligation to agree to any such settlement. 
 (c) Treatment of Indemnification Payments;
Insurance Recoveries. Any payment made pursuant to the indemnification obligations arising under this Agreement shall be treated as an adjustment to the Purchase Price to the extent allowable under Applicable Law. Any indemnity payment under
this Agreement shall be decreased by any amounts actually received by the Indemnified Party under Third Party insurance policies with respect to such Damage prior to the time payment by the Indemnifying Party is due and payable under this Agreement
(net of any premiums paid by such Indemnified Party under the relevant insurance policy and any costs incurred by such Indemnified Party in procuring such payment under such policy), each Party agreeing (i) to use commercially reasonable
efforts to recover all available insurance proceeds 

  
 44 

 
and (ii) to the extent that any indemnity payment under this Agreement has been paid by the Indemnifying Party to or on behalf of the Indemnified Party prior to the receipt, directly or
indirectly, by the Indemnified Party of any net insurance proceeds under Third Party insurance policies on account of such Loss which duplicate, in whole or in part, the payment made by the Indemnifying Party to or on behalf of the Indemnified
Party, the Indemnified Party shall remit to the Indemnifying Party an amount equal to the amount of the net insurance proceeds actually received by the Indemnified Party on account of such Loss which duplicate, in whole or in part, the payment made
by the Indemnifying Party to or on behalf of the Indemnified Party. 
 (d) In connection with any actual or threatened Third Party Claims by,
or actual or threatened litigation or other disputes with, Third Parties relating to Assumed Liabilities or Excluded Liabilities, any such claims, litigation and disputes being referred to as “claims” for purposes of this
Section 9.3(d), the Indemnified Party shall cooperate in the defense by the Indemnifying Party of such claim (and the Indemnified Party and the Indemnifying Party agree with respect to all such claims that a common interest privilege
agreement exists between them), including, (i) permitting the Indemnifying Party to discuss the claim with such officers, employees, consultants and representatives of the Indemnified Party as the Indemnifying Party reasonably requests,
(ii) permitting the Indemnifying Party to have reasonable access to the properties, books, records, papers, documents, plans, drawings, electronic mail, databases and computers of the Indemnified Party at reasonable hours to review information
and documentation relative to the claim, (iii) providing to the Indemnifying Party copies of documents and samples of the Product as the Indemnifying Party reasonably requests in connection with defending such claim, (iv) permitting the
Indemnifying Party to conduct privileged interviews and witness preparation of officers, employees and representatives of the Indemnified Party as the Indemnifying Party reasonably requests, (v) preserving all properties, books, records,
papers, documents, plans, drawings, electronic mail and databases included in the Purchased Assets relating to matters relating to Excluded Liabilities (in the case of the Purchaser) and Assumed Liabilities (in the case of Seller) in accordance with
such Party’s corporate documents retention policies, or longer to the extent reasonably requested by the other Party in connection with any actual or threatened action that would reasonably be expected to result in a claim for indemnification
hereunder, (vi) promptly collecting documents and extracting information from documents for the Indemnifying Party’s review and use, as the Indemnifying Party reasonably requests, or allowing the Indemnifying Party’s representatives
to do the same, (vii) notifying the Indemnifying Party promptly of receipt by the Indemnified Party of any subpoena or other Third Party request for documents or interviews and testimony, (viii) providing to the Indemnifying Party copies
of any documents produced by the Indemnified Party in response to or compliance with any subpoena or other Third Party request for documents, and (ix) permitting the Indemnifying Party to conduct such other reasonable investigations and
studies, and take such other actions, as are reasonably necessary in connection with the Indemnifying Party’s defense or investigation of such claim. In connection with any claims, except to the extent inconsistent with the Indemnified
Party’s obligations under Applicable Law and except to the extent that to do so would subject the Indemnified Party or its employees, agents or representatives to criminal or civil sanctions, (1) unless ordered by a court to do otherwise,
the Indemnified Party shall not produce documents to a Third Party until the Indemnifying Party has been provided a reasonable opportunity to review, copy and assert privileges covering such documents, (2) the transfer to the Indemnified Party
by the Indemnifying Party of documents covered by the Indemnifying Party’s attorney/client or work 

  
 45 

 
product privileges shall not constitute a waiver of such privileges, (3) unless otherwise ordered by a court, the Indemnified Party shall withhold from production to any Third Party any
documents as to which the Indemnifying Party asserts a privilege, (4) the Indemnified Party shall defend in court any such privilege asserted by the Indemnifying Party and (5) the Indemnified Party shall permit the Indemnifying Party to
prepare any employees of the Indemnified Party required or requested to testify or otherwise be deposed or interviewed in connection with any claim and to be present during any such testimony or interviews. 

Section 9.4 Certain Procedures. The Indemnified Party shall give the Indemnifying Party prompt written notice (an
“Indemnification Claim Notice”) (but in no event more than thirty (30) days after discovery) of any Losses or discovery of fact upon which such Indemnified Party intends to base a request for indemnification under
Section 9.1(a) or Section 9.1(b); provided, however, that failure to give such notice shall not relieve the Indemnifying Party of its obligations hereunder except to the extent it shall have been materially
prejudiced by such failure. Each Indemnification Claim Notice must contain a reasonable description of the claim and the nature and amount of such Losses (to the extent the nature and amount of such Losses are known at such time). The Indemnified
Party shall furnish promptly to the Indemnifying Party (but in no event more than thirty (30) days after discovery) copies of all papers and official documents received in respect of any Losses. All indemnification claims in respect of a Party,
its Affiliates or their respective directors, stockholders, members, officers, managers, employees and agents shall be made solely by such Party to this Agreement. 

Section 9.5 Guaranty. Parent hereby agrees to be responsible for, and guarantee to Seller, the full performance by
Purchaser, a wholly-owned subsidiary of Parent, and Opco, an indirect, wholly-owned subsidiary of Purchaser, and agrees to cause Purchaser and Opco to perform, all of their respective obligations and liabilities under or in connection with this
Agreement, the Ancillary Agreements and the transactions contemplated hereby and thereby. The liability of Parent under this Section 9.5 shall be irrevocable, absolute and independent. 

Section 9.6 Remedies Exclusive. Following the Closing, with the exception of remedies based on fraud, the remedies set
forth in this Article IX shall constitute the sole and exclusive remedy for money damages and shall be in lieu of any other remedies for money damages that may be available to the Indemnified Parties under any other agreement or pursuant to
any statutory or common law with respect to any Losses of any kind or nature incurred directly or indirectly resulting from or arising out of any of this Agreement, the Purchased Assets, the Assumed Liabilities or the Excluded Liabilities (it being
understood that nothing in this Section 9.6 or elsewhere in this Agreement shall affect the Parties’ rights to specific performance or other similar non-monetary equitable remedies with respect to the covenants referred to in this
Agreement to be performed after the Closing). The Parties each hereby waive any provision of any Applicable Law to the extent that it would limit or restrict the agreement contained in this Section 9.6. 

  
 46 

 ARTICLE X 

MISCELLANEOUS PROVISIONS 

Section 10.1 Confidentiality. 

(a) Reference is made to that certain letter agreement dated July 28, 2011, by and between Seller and Parent (the “Confidentiality
Agreement”). As used in this Section 10.1, the term “Evaluation Material” shall have the meaning assigned to such term in the Confidentiality Agreement. Upon the Closing, the Confidentiality Agreement shall expire and
be of no further force and effect with respect to all Evaluation Material relating to the Product Business, the Purchased Assets or the Assumed Liabilities, but all such Evaluation Materials shall thereafter be governed by the provisions of
Section 10.1(b); provided, however, such expiration of the Confidentiality Agreement shall in no way prejudice or adversely affect Seller’s ability to seek damages, or any other remedy available to Seller, with respect to a
violation by Purchaser, Parent or Opco (or their respective Affiliates or representatives) of the Confidentiality Agreement prior to or after the Closing. Upon and after the Closing, the Confidentiality Agreement shall remain in full force and
effect pursuant to its terms with respect to all other Evaluation Material that does not relate to the Product Business, the Purchased Assets or the Assumed Liabilities. 

(b) From and after the Closing, all confidential information and all Evaluation Material relating to the Product Business, the Purchased Assets
and the Assumed Liabilities shall constitute the “Purchaser Confidential Information” and shall be used by Seller solely as required to perform its obligations, exercise or enforce its rights under this Agreement (or any Ancillary
Agreement), or comply with Applicable Law, and for no other purpose. Seller shall not disclose, or permit the disclosure of, any of the Purchaser Confidential Information to any Person except those Persons to whom such disclosure is necessary to
permit Seller to perform its obligations, exercise or enforce its rights under this Agreement (or any Ancillary Agreement), or comply with Applicable Law. Seller shall treat, and will cause its Affiliates and the directors, officers, employees,
agents, representatives and advisors of Seller or any of their Affiliates to treat, the Purchaser Confidential Information as confidential, using the same degree of care as Seller normally employs to safeguard its own confidential information from
unauthorized use or disclosure, but in no event less than a reasonable degree of care. 
 (c) All confidential information obtained by
Purchaser, Parent or Opco (or their respective Affiliates or representatives) from Seller (or its Affiliates or representatives) other than the Purchaser Confidential Information (the “Seller Confidential Information”) shall be used
by Purchaser, Parent and Opco solely as required to perform their respective obligations, exercise or enforce its rights under this Agreement (or any Ancillary Agreement), or comply with Applicable Law, and for no other purpose. Purchaser, Parent
and Opco shall not disclose, or permit the disclosure of, any of Seller Confidential Information to any person except those persons to whom such disclosure is necessary to permit Purchaser, Parent and Opco to perform their respective obligations,
exercise or enforce their respective rights under this Agreement (or any Ancillary Agreement), or comply with Applicable Law. Purchaser, Parent and Opco shall each treat, and will cause their respective Affiliates and the directors, officers,
employees, agents, representatives and advisors of Purchaser, Parent and Opco or any of their Affiliates to treat, Seller Confidential Information as confidential, using the same degree of care as Purchaser,

  
 47 

 
Parent and Opco normally employs to safeguard its own confidential information from unauthorized use or disclosure, but in no event less than a reasonable degree of care. 

(d) In the event any Party is requested pursuant to, or required by, Applicable Law to disclose any of any other Party’s Confidential
Information (i.e., Seller Confidential Information or Purchaser Confidential Information, as applicable), it will notify the other Party in a timely manner so that such Party may seek a protective order or other appropriate remedy or, in such
Party’s sole discretion, waive compliance with the confidentiality provisions of this Agreement. Each Party will co-operate in all reasonable respects, in connection with any reasonable actions to be taken for the foregoing purpose. In any
event, the Party requested or required to disclose such Confidential Information may furnish it as requested or required pursuant to Applicable Law (subject to any such protective order or other appropriate remedy) without liability hereunder,
provided that such Party furnishes only that portion of the Confidential Information which such Party is advised by a reasoned opinion of its counsel is legally required, and such Party exercises reasonable efforts to obtain reliable assurances that
confidential treatment will be accorded such Confidential Information. 
 (e) Nothing in this Section 10.1 shall be construed as
preventing or in any way inhibiting any Party from complying with Applicable Law governing activities and obligations undertaken pursuant to this Agreement, in any manner which it reasonably deems appropriate, including, for example, by disclosing
to Governmental Authorities confidential or other information of the other Party. 
 Section 10.2 Notices. All notices,
requests and other communications required or permitted under, or otherwise made in connection with, this Agreement, shall be in writing and shall be deemed to have been duly given (a) when delivered in person, (b) upon confirmation of
receipt when transmitted by facsimile transmission, or (c) on the next Business Day if transmitted by national overnight courier (with confirmation of delivery), in each case, addressed as follows: 

if to Seller, to: 
 InterMune,
Inc. 
 3280 Bayshore Boulevard 

Brisbane, CA 94005 
 Attention:
General Counsel 
 Facsimile No.: (415) 466-2300 

with a copy to (which shall not constitute notice): 

Latham & Watkins LLP 

140 Scott Drive 
 Menlo Park, CA
94025 
 Attention: Mark V. Roeder, Esq. 

Facsimile No.: (650) 463-2600 

if to Purchaser or Parent to: 

  
 48 

 Vidara Therapeutics International Limited 

Attention: Dr. Virinder Nohria 

c/o Fairisle Management Limited 

The Penthouse, Washington Mall I 

20 Church Street 
 Hamilton HM 11

 Bermuda 
 Facsimile No.:
(441) 295-4614 
 if to Opco to: 

Vidara Therapeutics Research Limited 

Adelaide Chambers 
 Peter Street

 Dublin 8 
 Ireland 

Attention: David Kelly 
 Facsimile
No.: 353-1-449-3251 
 with a copy to (which shall not constitute notice): 

Burke, Warren, MacKay & Serritella, P.C. 

330 North Wabash Avenue, Suite 2200 

Chicago, IL 60611 
 Attention:
Christopher R. Manning 
 Facsimile No.: (312) 840-7900 

or to such other address or facsimile number as such Party may hereafter specify for the purpose by notice to the other parties hereto in accordance with the
terms of this Section 10.2. 
 Section 10.3 Bulk Transfers. Purchaser waives compliance with the provisions
of all Applicable Laws relating to bulk transfers in connection with the transfer of the Purchased Assets. 
 Section 10.4
Remedies Cumulative; Specific Performance. The rights and remedies of the Parties shall be cumulative (and not alternative). The Parties agree that irreparable damage would occur if any provision of this Agreement were not performed in
accordance with the terms hereof and that the Parties shall be entitled to an injunction or injunctions to prevent breaches of this Agreement or to enforce specifically the performance of the terms and provisions of this Agreement in addition to any
other remedy to which they are entitled to at law or in equity, in each case without the requirement of posting any bond or other type of security. 

Section 10.5 Further Assurances; Further Cooperation. Subject to the terms and conditions hereof, each of the
Parties agrees to use commercially reasonable efforts to execute and deliver, or cause to be executed and delivered, all documents and to take, or cause to be taken, all actions that may be reasonably necessary or appropriate, in the reasonable
opinion of counsel for each Party, to effectuate the provisions of this Agreement, provided that all such actions are in accordance with Applicable Law. From time to time, whether at or after the 

  
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Closing, (i) Seller shall execute and deliver such further documents or instruments of conveyance, transfer and assignment and take all such other action, at Purchaser’s sole expense,
as Purchaser may reasonably require to more effectively convey, transfer and assign to Purchaser any and all ownership, right, title and interest in and to the Purchased Assets, including, without limitation, executing documents or instruments
necessary to permit Purchaser to record the transfer, conveyance and/or assignment of any and all Product Intellectual Property with any Governmental Authority and (ii) Purchaser, Parent and Opco will execute and deliver such further
instruments and take all such other action, at Seller’s sole expense, as Seller may reasonably require to more effectively assume the Assumed Liabilities. Upon reasonable request and during normal business hours, Purchaser, Parent, Opco and
Seller shall cooperate with each other, and shall cause their respective representatives and Affiliates to cooperate with each other, after the Closing to ensure the orderly transition of the Purchased Assets and Assumed Liabilities to Purchaser and
to minimize any disruption to the businesses of Seller, Purchaser, Parent and Opco that might result from the transactions contemplated hereby. 

Section 10.6 Amendments and Waivers. 

(a) Any provision of this Agreement may be amended or waived but only if, such amendment or waiver is in writing and is signed, in the case of
an amendment, by each Party to this Agreement or, in the case of a waiver, by the Party against whom the waiver is to be effective. No waiver by any Party hereto of any term or condition of this Agreement, in any one or more instances, shall be
deemed to be or construed as a waiver of the same or any other term or condition of this Agreement or any future occasions. 
 (b) No failure
or delay by any Party in exercising any right, power or privilege hereunder shall operate as a waiver thereof nor shall any single or partial exercise thereof preclude any other or further exercise thereof or the exercise of any other right, power
or privilege. The rights and remedies herein provided shall be cumulative and not exclusive of any rights or remedies provided by Applicable Law. 

Section 10.7 Expenses. Except as otherwise provided herein, all costs and expenses incurred in connection with this
Agreement, including all third-party legal, accounting, financial advisory, consulting or other fees and expenses incurred in connection with the transactions contemplated hereby, shall be paid by the Party incurring such cost or expense.

 Section 10.8 Binding Effect; Benefit; Assignment. 

(a) The provisions of this Agreement shall be binding upon and shall inure to the benefit of the Parties and their respective successors and
assigns. Except as provided under this Agreement, no provision of this Agreement is intended to confer any rights, benefits, remedies, obligations or liabilities hereunder upon any Person other than the Parties and their respective successors and
assigns. 
 (b) Neither this Agreement nor any right, interest or obligation hereunder may be assigned by any Party hereto (other than to an
Affiliate of the Party) without the prior written consent of the other Party hereto (which consent shall not be unreasonably withheld) and any attempt to do so will be void; provided, however, that after the Closing, such prior written

  
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consent will not be required with respect to any assignment by any Party (a) to an Affiliate of such Party so long as such Party remains bound by the terms hereof, or (b) in connection
with a reorganization, merger, statutory share exchange, consolidation or similar change of control transaction involving the Seller or sale or transfer of all or substantially all of the assets of Seller, or, in the case of Purchaser, a sale or
transfer, regardless of form, involving all or substantially all of the assets associated with the Product Business. Except with respect to Section 8.14(a) of this Agreement which shall not apply to non-affiliated successors or assigns
of Seller, and except with respect to Section 8.14(b) of this Agreement which shall not apply to non-affiliated successors or assigns of Purchaser, Parent and Opco, this Agreement is binding upon, inures to the benefit of and is
enforceable by the Parties hereto and their respective successors and permitted assigns. For the avoidance of doubt, all obligations pursuant to Section 8.14(a) shall automatically and immediately terminate and cease to be enforceable
against any non-affiliated successor or assign of Seller and all obligations pursuant to Section 8.14(b) shall automatically and immediately terminate and cease to be enforceable against any non-affiliated successor of Parent, Purchaser
or Opco. Any attempt to assign this Agreement in violation of this Section 10.8(b) shall be void. Subject to this Section 10.8(b), any permitted assignee shall assume all obligations of its assignor under this Agreement pursuant
to a written instrument reasonably acceptable to the other Parties. In addition, nothing in this Agreement shall preclude Purchaser from providing its lenders with a security interest in its rights under this Agreement in accordance with the terms
of their security and collateral agreements in connection with any credit facility provided by such lenders to Purchaser or preclude such lenders from foreclosing upon such security interest in accordance with the terms of such security and
collateral agreements (including, without limitation, by means of the sale of the assets or stock of Purchaser to a Third Party including Purchaser’s rights and responsibilities under this Agreement), and any such action by such lenders shall
not be deemed to be a change of control for purposes of this Agreement. 
 (c) Nothing in this Agreement, express or implied, is intended to
or shall confer upon any Person other than the Parties and their respective successors and permitted assigns any right, benefit or remedy of any nature whatsoever under or by reason of this Agreement. 

Section 10.9 Governing Law. This Agreement shall be governed by and construed in accordance with the laws of the State of
Delaware, without giving effect to principles of conflicts of laws that would require the application of the laws of any other jurisdiction. 

Section 10.10 Jurisdiction. The Parties hereto agree that any Proceeding seeking to enforce any provision of, or
based on any matter arising out of or in connection with, this Agreement or the transactions contemplated hereby shall be brought in any federal court located in the State of Delaware or any Delaware state court, and each of the Parties hereby
irrevocably consents to the jurisdiction of such courts (and of the appropriate appellate courts therefrom) in any such Proceeding and irrevocably waives, to the fullest extent permitted by law, any objection that it may now or hereafter have to the
laying of the venue of any such Proceeding in any such court or that any such Proceeding brought in any such court has been brought in an inconvenient forum. Process in any such Proceeding may be served on any Party anywhere in the world, whether
within or without the jurisdiction of any such court. Without limiting the foregoing, each Party agrees that service of process on such party as provided in Section 10.2 shall be deemed effective service of process on such Party. 

  
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 Section 10.11 Waiver of Jury Trial. EACH OF THE PARTIES HERETO HEREBY
IRREVOCABLY WAIVES ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF OR RELATED TO THIS AGREEMENT OR THE TRANSACTIONS CONTEMPLATED HEREBY. 

Section 10.12 Arbitration. 

(a) With respect to any dispute, controversy or claim arising from or related to this Agreement or the breach thereof that is not an Excluded
Claim (“Dispute”), such Dispute shall first be referred to an executive officer from each Party for attempted resolution by good faith negotiations. Any such Dispute shall be submitted to such senior executives no later than thirty
(30) days following such request by any Party. Such executives shall attempt in good faith to resolve any such Dispute within thirty (30) days after the submission of the Dispute. In the event the executives are unable to resolve the
Dispute, the Parties shall otherwise negotiate in good faith and use reasonable efforts to settle. If the Parties do no fully settle, and a Party wishes to pursue the matter, each such Dispute shall be finally resolved by binding arbitration in
accordance with the Commercial Arbitration Rules and Supplementary Procedures for Large Complex Disputes of the American Arbitration Association (“AAA”), and judgment on the arbitration award may be entered in any court having
jurisdiction thereof. 
 (b) The arbitration shall be conducted by a panel of three (3) persons experienced in the pharmaceutical
business: within thirty (30) days after initiation of arbitration, each of Purchaser and Seller shall select one person to act as arbitrator and the two selected arbitrators shall select a third arbitrator within thirty (30) days of their
appointment. If the arbitrators selected by Purchaser and Seller are unable or fail to agree upon the third arbitrator, the third arbitrator shall be appointed by the AAA. The place of arbitration shall be San Francisco, California, and all
proceedings and communications shall be in English. 
 (c) Any Party may apply to the arbitrators for interim injunctive relief until the
arbitration award is rendered or the controversy is otherwise resolved. Any Party also may, without waiving any remedy under this Agreement, seek from any court having jurisdiction any injunctive or provisional relief necessary to protect the rights
or property of that Party pending the arbitration award. The arbitrators shall have no authority to award punitive or any other type of damages not measured by a Party’s compensatory damages. Each Party shall bear its own costs and expenses and
attorneys’ fees and an equal share of the arbitrators’ fees and any administrative fees of arbitration. 
 (d) Except to the extent
necessary to confirm an award or as may be required by law, no Party nor an arbitrator may disclose the existence, content, or results of an arbitration without the prior written consent of each Party. In no event shall an arbitration be initiated
after the date when commencement of a legal or equitable proceeding based on the dispute, controversy or claim would be barred by the applicable Delaware statute of limitations. 

(e) For clarity, this Section 10.12 shall not apply to any Excluded Claim with the result that Excluded Claims shall not be subject
to resolution by arbitration in the absence of a separate agreement between the Parties to do so. 

  
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 Section 10.13 Counterparts; Effectiveness. This Agreement may be signed in any
number of counterparts, each of which shall be an original, with the same effect as if the signatures thereto and hereto were upon the same instrument. This Agreement shall become effective when each Party shall have received a counterpart hereof
signed by the other Party. Until and unless each Party has received a counterpart hereof signed by the other Party hereto, this Agreement shall have no effect, and no Party shall have any right or obligation hereunder (whether by virtue of any other
oral or written agreement or other communication). The exchange of a fully executed Agreement or any Ancillary Agreement (in counterparts or otherwise) by electronic transmission in .PDF format or by facsimile shall be sufficient to bind the Parties
to the terms and conditions hereof and thereof. 
 Section 10.14 Entire Agreement. This Agreement, the Ancillary
Agreements, the Confidentiality Agreement and each of the documents, instruments and agreements delivered in connection with the transactions contemplated by this Agreement, including each of the Exhibits, the Schedules, and the Seller Disclosure
Schedule, constitute the entire agreement between the Parties with respect to the subject matter of this Agreement and supersede all prior agreements and understandings, both oral and written, between the Parties with respect to the subject matter
of this Agreement. 
 Section 10.15 Severability. If any term, provision, covenant or restriction of this
Agreement is held by a court of competent jurisdiction or other Governmental Authority to be invalid, void or unenforceable, the remainder of the terms, provisions, covenants and restrictions of this Agreement shall remain in full force and effect
and shall in no way be affected, impaired or invalidated so long as the economic or legal substance of the transactions contemplated hereby is not affected in any manner materially adverse to any Party. Upon such a determination, the Parties shall
negotiate in good faith to modify this Agreement so as to effect the original intent of the Parties as closely as possible in an acceptable manner in order that the transactions contemplated hereby be consummated as originally contemplated to the
fullest extent possible. 
 Section 10.16 Time is of the Essence. Time is of the essence with respect to
the performance of this Agreement. 
 (Signatures Pages Follow) 

  
 53 

 IN WITNESS WHEREOF, the Parties have caused this Agreement to be executed as of the
Agreement Date. 
  

			
	VIDARA THERAPEUTICS INTERNATIONAL LIMITED
		
	By:		/s/ Virinder Nohria
	Name:		Virinder Nohria
	Title:		President

  

			
	VIDARA THERAPEUTICS HOLDINGS LLC
		
	By:		/s/ Bala Venkataraman
	Name:		Bala Venkataraman
	Title:		Chairman and Treasurer

  

			
	VIDARA THERAPEUTICS RESEARCH LIMITED
		
	By:		/s/ David G. Kelly
	Name:		David G. Kelly
	Title:		Director & Chief Financial Officer

  

			
	INTERMUNE, INC.
		
	By:		/s/ John C. Hodgman
	Name:		John C. Hodgman
	Title:		Chief Financial Officer and Senior Vice President, Finance

 Signature Page to Asset Purchase Agreement

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