Document:

EXHIBIT 10.44

                            THIRD AMENDMENT TO LEASE

         THIRD AMENDMENT TO LEASE made as of February 12, 2004, (the "Third
Amendment") by and between STELLAR CONTINENTAL LLC, a Delaware limited liability
company, with an office at 156 William Street, New York, New York 10038
("Lessor"), and DOV PHARMACEUTICALS INC., a Delaware corporation, located at 433
Hackensack Avenue, Hackensack, New Jersey 07601 ("Lessee").

                              W I T N E S S E T H:

         WHEREAS, Lessor's predecessor-in-interest and Lessee entered into a
lease dated May 24, 1999, as modified by a First Amendment to Lease dated July
31, 2000 (the "First Amendment") and a Second Amendment to Lease dated July 30,
2002 (the "Second Amendment"; the lease, as amended by the First Amendment and
the Second Amendment is hereinafter referred to as, the "Lease") whereby Lessee
is currently in possession of 7,185 gross rentable square feet on the lobby
level and 4,099 gross rentable square feet on the twelfth (12th) floor of the
Building (together, hereinafter, the "Existing Premises") of the building known
as 433 Hackensack Avenue, Hackensack, New Jersey (the "Building"); and

         WHEREAS, the Building is part of an office complex consisting of 401,
407, 411 and 433 Hackensack Avenue, Hackensack, New Jersey, which complex is
known as Continental Plaza (the "Complex"); and

         WHEREAS, Lessee wishes to lease and hire from Lessor, additional space
consisting of approximately 4,420 gross rentable square feet on the lobby level
of the Building (the "Additional Space'), as shown on Exhibit A annexed hereto
and made a part hereof, and Lessor is willing to lease the Additional Space to
Lessee; and

         WHEREAS, Lessor and Lessee wish to amend the Lease only upon and
subject to the provisions of this Third Amendment.

         NOW, THEREFORE, in consideration of the sum of Ten ($10.00) Dollars and
other good and valuable consideration exchanged by Lessor and Lessee, the
receipt and sufficiency of which hereby expressly are acknowledged; it is
AGREED:

         1. For the purposes of this Third Amendment, capitalized terms used
herein and not otherwise defined herein shall have the respective meanings
ascribed to them in the Lease.

         2. Lessor and Lessee hereby confirm that the Expiration Date of the
Lease is June 25, 2004. The Term is hereby extended from June 25, 2004 to and
including June 30, 2005; and Reference Page Sections (15) and (16) of the Lease
are deemed amended accordingly.

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         3. As of the date first written above (the "Effective Date"), and in
accordance with the provisions hereinafter contained, the Additional Space is
hereby Leased to Lessee by Lessor, and hired from Lessor by Lessee, through the
balance of the Term, such that the Existing Premises and Additional Space shall
be hereafter collectively referred to as the "Demised Premises" unless the
context dictates otherwise.

         4. With respect to the Existing Premises, only from and after the
Effective Date:

            (a) from the Effective Date through the remainder of the Term,
                Lessee shall pay to Lessor Annual Fixed Basic Rent in the sum of
                $293,384 (exclusive of Electric Rent Inclusion Factor for the
                Existing Premises and the Monthly Fixed Basic Rent shall be
                $24,448.69);

            (b) Lessee's Electric Rent Inclusion Factor shall be $16,926 per
                annum ($1,410.50 per month);

            (c) provided Lessee is not in default beyond the expiration of any
                applicable notice or cure periods and notwithstanding anything
                contained herein to the contrary, Lessee shall be entitled to a
                Term Fixed Basic Rent abatement in the amount of $36,673.00,
                said concession to be applied against the installments of
                Monthly Fixed Basic Rent due pursuant to this Lease, as amended,
                for the (i) the month commencing on July 1, 2004 and (ii) half
                of the month commencing on August 1, 2004 following the
                Effective Date (the "Concession Period"). The entire Fixed Basic
                Rent otherwise due and payable during the Concession Period
                shall become due and payable to Lessor upon the occurrence of an
                event of default by Lessee under the Lease.

         5. With respect to the Additional Space only from and after the
Effective Date:

            (a) the Annual Fixed Basic Rent shall be $88,400.00 (exclusive of
                the Electric Rent Inclusion Factor for the Additional Space, as
                described herein), and the Monthly Fixed Basic Rent shall be
                $7,366.67.

            (b) Lessee's Percentage shall be 0.75%;

            (c) the Base Operating Costs, Base Real Estate Taxes and Base
                Utility and Energy Costs shall be those Costs incurred during
                "Calendar Year 2004";

            (d) Lessee's Electric Rent Inclusion Factor shall be $6,630.00 per
                annum ($552.50 per month);

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            (e) Lessee shall be entitled to eighteen (18) non-reserved parking
                spaces of which twelve (12) shall be in the covered garage; and

            (f) Lessee shall be given rights respecting directory listings, keys
                and signage in proportion to the increase in gross rentable
                square footage leased by Lessee pursuant to the Lease as amended
                by this Amendment by reason of Lessee leasing the Additional
                Space.

            (g) Lessee has inspected the Additional Space, Building and Complex,
                and is thoroughly acquainted with their respective conditions
                and agrees to take same in its "AS IS" condition as of the date
                hereof.

            (h) Except as provided in this Third Amendment, the letting of the
                Additional Space shall be upon all of the terms and conditions
                of the Lease.

            (i) Lessee represents and warrants to Lessor that Cushman &
                Wakefield of New Jersey, Inc. ("Broker") is the sole broker with
                whom Lessee has dealt in bringing about this Third Amendment.
                Lessee and Lessor each agrees to hold the other harmless and
                indemnify and defend the other from and against any and all
                loss, cost, liability, damage and expense arising out of the
                inaccuracy of the representation contained in the preceding
                sentence and each party represents to the other that it has not
                engaged and is not responsible for the payment of a fee,
                commission or other compensation to any other person in
                connection with the Lease or the Third Amendment. Lessor shall
                pay Broker any fees or commissions due Broker as a result of
                this Third Amendment pursuant to the terms of a separate
                agreement with Broker.

            (j) Lessee and Lessor each represents, warrants and covenants that
                the other is not in default under any of its obligations under
                the Lease and that, to the best of its knowledge, the other is
                not in default of its obligations under the Lease, and no event
                has occurred nor do any circumstances exist which, with lapse of
                time or notice or both, would constitute a default by Lessor or
                Lessee under the Lease as modified by this Third Amendment.

            (k) Except as modified by this Third Amendment, the Lease and all of
                the covenants, agreements, terms, provisions and conditions
                thereof shall remain in full force and effect and are hereby
                ratified and affirmed. The covenants, agreements, terms,
                provisions and conditions contained in this Third Amendment
                shall bind the parties hereto and their respective successor and
                assigns and shall inure to the benefit of the parties hereto and
                their respective permitted successors and assigns. In the event
                of any conflict between the provisions of this Third

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<PAGE>

                Amendment and the Lease, the provisions contained in this Third
                Amendment shall prevail and be paramount.

            (l) The submission of this Third Amendment for examination does not
                constitute a reservation of, or option for, the Additional Space
                and this Third Amendment becomes binding and effective only upon
                execution and delivery thereof by Lessor and Lessee.

         6. (a) Lessor agrees that, at Lessor's expense, it will do
     substantially all of the work in the Additional Space in accordance with
     Exhibit B ("Lessor's Work") attached hereto and made a part hereof.

                  (b) Lessee hereby agrees to contribute up to a maximum amount
of $49,991.00 toward the actual cost of Lessor's Work (the "Lessee's
Contribution"), which Lessee's Contribution shall be paid by Lessee to Lessor as
follows: (i) $24,995.00 upon Lessee's execution of Lease, (ii) $12,498 upon the
delivery, the roughing inspection to Lessee and (iii) $12,498 upon the earlier
to occur of (x) occupancy of the Demised Premises by Lessee or (y) the delivery
of a Certificate of Occupancy for the Additional Space (if required pursuant to
local law).

                  (c) All of Lessor's Work, whether paid for in whole or in part
by Lessee, is and shall remain the property of Lessor.

         7. Section 45 of the Lease is herby deleted in its entirety and the
         following is substituted therefor:

         Any notice by either party to the other shall be in writing and shall
         be deemed to have been duly given only if (a) delivered personally or
         (b) sent by registered mail or certified mail in a postpaid envelope or
         by regulated carrier service with return receipt or (c) sent by
         nationally recognized overnight courier service such as Federal
         Express, addressed if to Lessee, at the above-described Building, with
         a copy to Shepard, Federgreen, Gibbons Del Deo, et al, One Riverside
         Plaza, Newark, New Jersey 07102-5496; if to Lessor, at Lessor's address
         as set forth above, with copy to Meister Seelig & Fein LLP, 708 Third
         Avenue, 24th Fl., New York, New York 10017, Attention: Stephen B.
         Meister, Esq.; or to either at such other address as Lessee or Lessor,
         respectively, may designate in writing. Notice shall be deemed to have
         been duly given upon its receipt or rejection as evidenced by a bill of
         lading or return receipt or upon delivery if personally served.

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         IN WITNESS WHEREOF, Lessor and Lessee have entered into this Third
Amendment as of the day and year first written above, and acknowledge one to the
other that they possess the requisite authority to enter into this transaction
and to sign this Third Amendment.

DOV PHARMACEUTICALS, INC.           STELLAR CONTINENTAL LLC
                                    By: Stellar Capital Investors LLC,
                                        Its Manager

By:____________________________     By:________________________________

                                       5EXHIBIT 10.45

                            DOV PHARMACEUTICAL, INC.
                             AUDIT COMMITTEE CHARTER

I.  General Statement of Purpose

         The primary function of the audit committee is to assist the board of
directors in fulfilling its oversight responsibilities by reviewing the
qualifications and performance of the company's independent accountants and the
financial reports and other financial information provided by the company to
governmental bodies or the public, and to review and monitor the company's
system of internal controls and the company's auditing, accounting and financial
reporting processes. In carrying out its primary function the audit committee
shall also provide an open avenue of communication among the independent
auditors, financial and senior management and the board of directors. The audit
committee shall fulfill these responsibilities by carrying out the activities
enumerated in section V of this charter.

II.  Composition

         The audit committee shall consist of at least three members of the
board, each of whom must be independent according to both NASD rules and the
Sarbanes-Oxley Act of 2002, and moreover not own or control 20% or more of the
company's voting securities, or such lesser amount as may be established by the
SEC.

         As an exception to the above independence criteria, a director who is
not an employee or family member and meets all the above qualifications except
those of the NASD can be an audit committee member. For this to occur, the
board, under exceptional and limited circumstances, must determine that the
director's membership is required in the best interests of the company and its
stockholders. The company must then disclose, in the next following annual proxy
statement, its reasons for that determination. A member appointed and whose
appointment continues under this exception may not serve on the audit committee
for more than two years and may not chair the committee.

         Each member of the audit committee must be able to understand financial
statements. Moreover, at least one member of the audit committee must be a
"financial expert" under SEC rules. Those rules require among other things that,
in addition to understanding financial statements, the financial expert have an
understanding of generally accepted accounting principles and their application
as well as experience with internal controls for financial reporting.

         Members of the audit committee shall be appointed annually by the board
and may be replaced or removed by the board with or without cause. Resignation
or removal of a director, for whatever reason, shall if a member mean automatic
resignation or removal from the audit committee. Any vacancy on the audit
committee may be filled only by the board. The board shall designate one member
of the audit committee to be the chair.

<PAGE>

III.  Compensation

         A member may not, other than in his or her capacity as a member of the
audit committee, the board or any other board committee, receive any
compensation from the company. A member may receive additional director fees to
compensate for the significant time and effort required to serve on the audit
committee.

IV.  Meetings

         The audit committee shall meet not less frequently than quarterly to
review each quarterly earnings release and quarterly report, and at least on one
further occasion to review internal controls, audit progress and the annual
report. Apart from these required meetings, the committee may have additional
meetings as often as it determines. A majority of the members of the audit
committee shall constitute a quorum for purposes of holding a meeting and the
committee may act by a vote of a majority of the members present at the meeting.
In lieu of a meeting, where warranted in special circumstances the audit
committee may act by unanimous written consent.

V.  Responsibilities and Authority

Matters Relating to Selection, Performance and Independence of Auditors

     o  Sole authority to appoint (subject to stockholder ratification),
        terminate and determine funding for auditors

     o  Instruct auditors to report directly to audit committee

     o  Exercise oversight of auditors' work including resolution of
        disagreements between management and auditors

     o  Pre-approval of all audit, audit-related, tax and other services not
        prohibited by SEC or Public Company Accounting Oversight Board

     o  Pre-approval of audit-related and non-audit services may be delegated to
        one or more members of audit committee

     o  Review and approve scope and staffing of auditors' overall audit plan

     o  Require auditors to provide audit committee with written disclosures and
        letter required by Independence Standards Board Standard No. 1, and to
        submit to audit committee on a periodic basis a formal written statement
        delineating all relationships between auditors and company

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<PAGE>

     o  Discuss with auditors any disclosed relationships or services that may
        impact objectivity and independence, and take appropriate action to
        satisfy audit committee of auditors' independence

     o  Determine whether services of auditors reported in annual report or
        proxy statement are compatible with maintaining auditors' independence

Audited Financial Statements

     o  Review overall audit plan with auditors and management responsible for
        preparing company's financial statements

     o  Review and discuss with management and auditors as appropriate:

        o   Company's annual audited financial statements including all critical
            accounting policies and practices used or to be used by company and
            any significant financial reporting issues that have arisen in
            connection with preparation of audited financial statements, prior
            to filing company's annual report

        o   Any analysis prepared by management or auditors setting forth
            significant financial reporting issues and judgments made in
            connection with preparation of financial statements including
            analyses of effect of alternative GAAP methods on financial
            statements

        o   Ramifications of use of such alternative disclosures and treatments
            on financial statements and treatment preferred by auditors, and
            consider other material written communications between auditors and
            management including any management letter or schedule of unadjusted
            differences

        o   Adequacy of company's internal controls and procedures for financial
            reporting and risk management policies

        o   Major changes in and other issues regarding accounting and auditing
            principles and procedures including any significant changes in
            company's selection or application of accounting principles and

        o   Effect on financial statements of regulatory and accounting
            initiatives as well as off-balance sheet transactions and structures

     o  Review and discuss outside presence of management any audit problems or
        difficulties and management's response thereto including any
        difficulties encountered by auditors in the course of their work,
        including any restrictions on scope of their activities or access to
        information, responsibilities, budget and

                                      -3-
<PAGE>

        staffing of company's internal audit function if any or financial
        reporting function and any significant accounting issues raised with
        management

     o  Review and discuss matters brought to attention of audit committee by
        auditors pursuant to Statement on Auditing Standards No. 61 and No. 90
        (SAS 61 and SAS 90) including any

        o   Restriction on scope of auditors' activities or access to requested
            information

        o   Accounting adjustments proposed by auditors but not made by
            management

        o   Communication between auditors and its national office regarding
            significant auditing or accounting issues presented by management

        o   Management or internal control letter issued, or proposed to be
            issued, by auditors and

        o   Significant disagreement between company and auditors

     o  Review and discuss with auditors their report pursuant to Securities
        Exchange Act on their non-audit services if any

     o  Discuss with CEO, CFO and general counsel significant deficiencies and
        material weaknesses brought to audit committee's attention in design or
        operation of internal controls and procedures for financial reporting
        that could adversely affect company's ability to record, process,
        summarize and report financial information or reveal any fraud involving
        management or other employees who have a significant role in company's
        internal controls and procedures for financial reporting

     o  Based on its review and discussions with management including review of
        matters required to be discussed by SAS 61 and SAS 90, recommend to
        board whether company's audited financial statements should be included
        in 10-K

     o  Prepare audit committee report required by Item 306 of Regulation S-K to
        be included in company's annual proxy statement

Unaudited Quarterly Financial Statements

     o  Discuss with management and review any financial information including
        press releases and Form 10-Q submitted to a governmental body or the
        public including any certification, report, opinion or review by the
        independent auditors.

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<PAGE>

Procedures for Addressing Complaints and Concerns

     o  Establish and require company to publish or file procedures for receipt,
        retention and treatment of complaints received by company regarding
        accounting, internal accounting controls or auditing matters and
        confidential, anonymous submission to audit committee by employees of
        concerns regarding questionable accounting or auditing matters or
        disclosure controls

Regular Reports to Board

     o  Regularly report to and review with board any issues that arise with
        respect to quality or integrity of company's financial statements,
        compliance with legal or regulatory requirements, performance and
        independence of auditors, performance of internal audit function if any
        and any other matters that audit committee considers appropriate or is
        requested by board to review

Review of Charter

     o  Review at least annually and more often as appropriate adequacy of
        charter and recommend amendments if any to board

Engagement of Advisors

     o  Engage and determine compensation for independent counsel to audit
        committee and such other advisors necessary or appropriate to carry out
        its responsibilities and powers

Legal and Regulatory Compliance

     o  Discuss with management legal and regulatory requirements applicable to
        company and its subsidiaries and company's compliance, and make
        recommendations to board regarding compliance

     o  Discuss with CEO, CFO and general counsel legal matters (including
        pending or threatened litigation) that may have a material effect on
        company's financial statements or its legal and regulatory compliance
        policies and procedures

General

     o  Form and delegate authority to subcommittees consisting of one or more
        of its members to carry out its responsibilities and exercise its powers

                                      -5-
<PAGE>

     o  Require that any officer or employee of company, company's outside legal
        counsel, auditors or any other professional retained by company attend a
        meeting of audit committee or meet with any member of or advisor to
        committee

                                      * * *

         Notwithstanding the responsibilities and powers of the audit committee
set forth in this charter, it is not intended to carry responsibility for
planning or conducting audits of the company's financial statements or
determining whether the company's financial statements are complete, accurate
and prepared in accordance with GAAP. Such responsibilities are the duty of
management and, to the extent of their audit responsibilities, the auditors. In
addition, it is not the duty of the audit committee to conduct investigations or
to assure compliance with laws and regulations. The audit committee shall be
entitled to rely upon advice and information it receives if it believes to be
reliable or has reason to draft in its discussions and communications with
management, auditors and such experts, advisors and professionals it may
consult.

(ADOPTED BY THE BOARD OF DIRECTORS MARCH 21, 2003,  AND AMENDED MARCH 11, 2004)

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