Document:

Exhibit 3.39

                         AMENDMENT OF PURCHASE AGREEMENT
                              DATED AUGUST 25, 2000

      AMENDMENT, dated April 15, 2002 (the "Amendment") among Milestone
Scientific Inc., a Delaware corporation with its principal offices at 220 South
Orange Avenue, Livingston, New Jersey 07039 ("the Company"), and the holders of
Milestone's 20% Secured Promissory Notes (the "Notes") (individually, the
"Noteholder" and collectively, the "Noteholders") to the Purchase Agreement
dated August 25, 2000.

                                    RECITALS

      WHEREAS, pursuant to a Purchase Agreement, dated August 25, 2000, among
the Company and the Noteholders (the "Agreement"), each Noteholder purchased
from the Company a 20% Secured Promissory Note, dated August 28, 2000 (the
"Notes") on which, as of March 31, 2002, there is a balance of principal and
interest in the amounts set forth opposite each Noteholder's name on Schedule A;

      WHEREAS, Milestone and the undersigned Noteholders desire to amend the
Agreement and exchange their Notes for the Company's 6%/12% Senior Secured
Promissory Notes (the "New Notes") as described herein;

      NOW, THEREFORE, in consideration of the promises set forth below and other
good and valuable consideration, the sufficiency of which is hereby
acknowledged, the undersigned hereby agree as follows:

      1. The Company shall issue to each Noteholder a New Note having the
following terms:

      a.    The issuance date shall be as of March 31, 2002 (the "Issuance
            Date");

      b.    The maturity date shall be July 1, 2003 (the "Maturity Date");

      c.    The face value shall be equal to the outstanding principal and
            interest on the Noteholder's Note as of March 31, 2002 (the "Face
            Value");

      d.    Interest shall accrue on the Face Value at the rate of 6% per annum
            from the Issuance Date to the Maturity Date, if paid in cash, or 12%
            per annum from the Issuance Date to the Maturity Date, if paid in
            Common Stock, as defined below. Interest shall be payable on the
            Maturity Date;

      e.    At the option of the Company, the Face Value shall be payable either
            in cash or in shares of the Company's Common Stock, Par value $.001
            per share (the "Common Stock"), valued at the average closing price
            per share of the Common Stock for the five trading days ending the
            day prior to the Maturity Date of the New Notes, provided that such
            shares of Common Stock have been registered pursuant to the
            Registration Rights Agreement

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            among the Company and Noteholders, dated August 25, 2000 (the
            "Registration Rights Agreement");

      f.    The New Notes shall continue to be secured by raw material, work in
            process, finished goods inventories and certain proceeds thereof,
            copyrights, trademarks and other intellectual property that may now
            or hereinafter be owned by the Company, and the Company shall
            execute and deliver such documents and instruments and take other
            reasonable actions to insure that the Noteholders have a perfected
            first security interest in the above mentioned assets, all pursuant
            to the Security Agreement dated August 25, 2000 among the Company
            and the Noteholders (the "Security Agreement"), which is hereby
            amended to substitute the New Note for the Note in all references;

      g.    The payment of the entire Face Value, including all accrued
            interest, of the New Notes, shall be senior in right of payment to
            all other indebtedness of the Company, whether incurred prior or
            subsequent to the date of thereof other than (i) any purchase money
            obligations incurred by the Company in connection with the purchase
            of property in the ordinary course of business, and (ii) all payment
            obligations of the Company pursuant to any capitalized lease entered
            into by the Company, and (iii) all payables incurred by the Company
            in the ordinary course of its business; and

      h.    It is confirmed that there are no restrictions on the Company's
            right to obtain additional unsecured loans so long as they bear a
            maturity date that is subsequent to August 1, 2003.

      i.    Except as otherwise provided herein, the provisions of the Note
            relating to the rights of the Noteholders and the obligations of the
            Company shall be incorporated into the New Notes, which shall appear
            substantially in the form annexed hereto as Exhibit A.

      2. Each Noteholder shall promptly return his Notes to the Company in
exchange for the New Notes in the amount set forth opposite his name on Schedule
A.

      3. The Company's obligations and the rights of the Noteholders under the
Notes shall terminate upon the execution of this Amendment by the holders of 80%
of the outstanding principal amount of the Notes, except for the right of the
Noteholders to exchange his Note for the New Note, as provided herein.

      4. As additional consideration for the extension of the maturity dates on
the Notes, the Company shall issue, to each of the undersigned Noteholders who
execute and return this Amendment to the Company by the close of business on
April 15, 2002, shares of the Company's Common Stock with a value of $120 for
each $1,000 Face Value of the New Note held by such Noteholder. The shares shall
be issued promptly

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<PAGE>

following maturity and will be valued at the average closing price during the
five trading days preceding maturity.

      5. The Registration Rights Agreement is hereby amended to include in the
definition of "Registrable Securities" as used therein any shares of Common
Stock that may be issued as payment on principal and interest on the New Notes.

      6. Except as otherwise provided herein, the Agreement, the Security
Agreement, the Warrants, and the Registration Rights Agreement shall continue
unchanged and in full force and effect.

      IN WITNESS WHEREOF, the undersigned have caused this Amendment to be
executed as of the date first above written.

                                           MILESTONE SCIENTIFIC INC.

                                           By: _________________________________
                                               Lenoard Osser
                                               Chairman and CEO

                                           CUMBERLAND BENCHMARKED PARTNERS, L.P.
                                           By CUMBERLAND ASSOCIATES

                                           By: _________________________________
                                               Bruce G. Wilcox
                                               Chairman, Management Committee

                                           CUMBERLAND PARTNERS, L.P.
                                           By CUMBERLAND ASSOCIATES

                                           By: _________________________________
                                               Bruce G. Wilcox
                                               Chairman, Management Committee

                                       3
<PAGE>

                                           LONGVIEW PARTNERS A, L.P.
                                           By CUMBERLAND ASSOCIATES

                                           By: _________________________________
                                               Bruce G. Wilcox
                                               Chairman, Management Committee

                                           LONGVIEW PARTNERS B, L.P.
                                           By CUMBERLAND ASSOCIATES

                                           By: _________________________________
                                               Bruce G. Wilcox
                                               Chairman, Management Committee

                                           LONGVIEW PARTNERS, L.P.
                                           By CUMBERLAND ASSOCIATES

                                           By: _________________________________
                                               Bruce G. Wilcox
                                               Chairman, Management Committee

                                       4
<PAGE>

                                   Scehdule A

Noteholder                                                Face value of New Note

Cumberland Partners                                            $  812,075.69
LongView Partners                                              $  182,336.85
LongView Partners B                                            $  123,461.66
Cumberland Benchmark Partners                                  $  227,530.11
LongView Partners A                                            $   19,951.68
                                                               -------------
                                                               $1,365,356.00

                                        5Exhibit 4.40

                                  AMENDMENT TO:

                   1. 10% PROMISSORY NOTE DATED MARCH 9, 2001
           2. 8% SENIOR SECURED PROMISSORY NOTES DATED JULY 25, 2000
          3. 8% SENIOR SECURED PROMISSORY NOTE DATED FEBRUARY 19, 2002

      AMENDMENT, dated April 12, 2002, (the "Amendment") by and between
Milestone Scientific Inc., a Delaware corporation, having its principal offices
at 220 South Orange Avenue, Livingston, New Jersey 07039 (the "Company"), and K.
Tucker Andersen (the "Lender"), having an address c/o Cumberland Associates LLC,
1114 Avenue of the Americas, New York, NY 10036.

      For good and valuable consideration, the sufficiency of which is hereby
acknowledged, the undersigned hereby agree to the following amendments to the:

      1.    10% Promissory Note dated March 9, 2001 in the amount of $500,000;
      2.    8% Promissory Note dated July 25, 2001 in the amount of $1,000,000;
            and
      3.    8% Promissory Note dated February 19, 2002 in the amount of
            $150,000.

between the Company and the Lender (collectively the "Notes"):

1.    The maturity dates of all the Notes are hereby extended to August 1, 2003
      except for a $500,000 balance on the 8% Promissory Note dated July 25,
      2001, which remains December 31, 2003

2.    It is confirmed that there are no restrictions on the Company's right to
      obtain additional unsecured loans so long as they bear a maturity date
      that is subsequent to August 1, 2003.

            IN WITNESS WHEREOF, the undersigned have caused this Amendment to be
executed as of the date first above written.

                                             MILESTONE SCIENTIFIC INC.

                                             By: _______________________________
                                                     Leonard Osser, Chairman and
                                                     Chief Executive Officer

                                                 _______________________________
                                                     K. TUCKER ANDERSEN

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