Document:

<PAGE>

                                                                         Ex 10.7

                    MUTUAL AND GENERAL RELEASE OF ALL CLAIMS

      This Mutual and General Release is entered into between CYTRX CORPORATION
(hereinafter "CYTRX"), and MADISON & WALL WORLDWIDE, INC. (hereinafter "M & W"),
and is intended by said parties to effect the legal consequences provided by
Section 1541 of the California Civil Code; that is, the extinguishment of
obligations as hereinafter set forth.

      In consideration of the payment by CYTRX to M & W of the sum of $50,000
cash and 200,000 shares of CYTRX common stock (the "Stock"), each of the parties
hereby mutually relinquishes their respective legal rights and those of their
heirs, legal representatives and assigns, affiliated partnerships or
corporations, their officers, directors, stockholders, or their successors and
assigns, receivers and trustees in bankruptcy, administrators, successors and
assigns, and all other persons, firms, corporations, associations, and
partnerships, and release one another from any and all liability and all future
claims, actions, interests, demands, rights, damages, costs, loss of services,
proceedings, debts, dues, sums of money, contracts, agreements, controversy,
expenses, and compensation, of any nature whatsoever, which the parties, or any
of them, may have or which may hereafter accrue on account of, or in any way
growing out of any and all known, and unknown, foreseen and unforeseen facts,
injuries or damages arising out of the facts alleged in the Complaint filed by M
& W entitled, Madison & Wall Worldwide, Inc. v. Cytrx Corporation, on April ___,
2004, Orange County Superior Court Case No. 04CC04463 (the "Incident").

      The Stock is being issued to M & W under a private placement exemption
under applicable federal and state securities laws. CYTRX has communicated to M
& W and M & W understands that CYTRX intends to file a Form S-1 registration
statement covering the resale of CYTRX securities by certain CYTRX shareholders
(the "Resale Registration Statement") within sixty days of filing its Form 10-K
for the year ended December 31, 2003 (the "2003 Form 10-K"). M & W represents
that it has reviewed the 2003 Form 10-K, including the "Risk Factors" section
contained therein. CYTRX will use its best efforts to register the Stock with
the Resale Registration Statement or with any new registration statement on Form
S-3 or any other

                                     - 1 -
<PAGE>

available Form (other than Form S-8 or Form S-4) that CYTRX files prior to the
filing of the Resale Registration Statement. Notwithstanding the foregoing,
CYTRX will not have an obligation to include the Stock in any registration
statement covering an underwritten offering in which the underwriter for that
offering advises CYTRX that it is not willing to include the Stock in that
registration statement, provided that at least 75,000 shares of the Stock are
included in that underwritten registration statement and the remaining 125,000
shares of the Stock will continue to have the registration rights set forth
above. In the event that CYTRX fails to include the Stock in the next new
registration statement (other than a Form S-8 or Form S-4 Registration
Statement) that it files after the date hereof that does not cover an
underwritten offering, CYTRX will pay M & W as liquidated damages $25,000 for
each 30-day period after that registration statement is filed during which CYTRX
has not filed a registration statement covering the Stock. CytRx and M & W shall
enter into a registration rights agreement reasonably acceptable to both parties
that sets forth the foregoing registration obligations of CYTRX and includes
other customary provisions for an agreement of this type.

      It is understood and agreed that this Mutual and General Release of All
Claims is the compromise of a disputed claim and that this Mutual and General
Release of All Claims is not to be construed as an admission of liability on the
part of any of the parties hereby released and that the parties hereby released
deny liability therefor and intend merely to avoid litigation and buy their
peace. This Mutual and General Release of All Claims is the result of bargaining
and negotiation by and between the parties, and represents a final, mutually
agreeable compromise.

      It is understood and agreed that each of the parties hereby expressly
waive all rights under Section 1542 of the Civil Code of California which
provides as follows:

            "CERTAIN CLAIMS NOT AFFECTED BY GENERAL RELEASE A general release
            does not extend to claims which the creditor does not know or
            suspect to exist in his favor at the time of executing the release,
            which if known by him must have materially affected his settlement
            with the debtor."

      The parties hereto, and each of them, fully understand that they cannot
hereafter make any further claim or seek any further recovery from the parties
being released herein by reason of

                                     - 2 -
<PAGE>

the aforesaid incident, and they expressly waive all future unknown claims
caused by, or alleged to be caused by, the aforesaid incident.

      The parties hereto, and each of them, further declare and represent that
there has been no other promise, inducement or agreement, and that this Mutual
and General Release of All Claims constitutes the ENTIRE AGREEMENT between the
parties hereto, and that the terms of this Mutual and General Release of All
Claims are contractual and not a mere recital.

      Full performance by each party hereto of each and all of their respective
obligations hereunder shall constitute a condition precedent to the
effectiveness of each of the releases and discharges made hereunder in their
favor.

      Each party hereto hereby represents and warrants that said party has not
assigned or otherwise transferred, and will not hereafter assign or otherwise
transfer, any interest in any claim which is released by said party hereunder,
and each party hereto agrees to indemnify, hold harmless and defend each and
every person and other entity who is released by said party hereunder, with
respect to any and all claims which may arise out of or by reason of any such
assignment or transfer of any interest in any such claim.

      This Mutual and General Release of All Claims may be executed in multiple
counterparts, each of which shall be deemed an original and all of which shall
constitute but one agreement. Copies of this Mutual and General Release of All
Claims, including facsimile copies may be used in lieu of the originals for all
purposes. If a party signs this Mutual and General Release of All Claims and
then transmits an electronic facsimile of the signature page to any other party,
that party who receives the transmission may rely upon the electronic facsimile
as a signed original of this Mutual and General Release of All Claims.

      All parties agree to keep this Mutual and General Release of All Claims
and its terms confidential and not disclose this Mutual and General Release of
All Claims and the facts and circumstances surrounding the transactions between
the parties to third parties, except disclosures (i) in response to a Summons or
Subpoena; (ii) by order or request of any governmental authority or
administrative agency; (iii) by Court Order; (iv) to senior management of each
party; (v) to attorneys, accountants or other professional advisors to a party
provided they

                                     - 3 -
<PAGE>

are instructed to keep this Mutual and General Release of All Claims
confidential; or, (vi) to enforce the terms of this Mutual and General Release
of All Claims.

      The parties hereto consent to the jurisdiction of the Los Angeles Superior
Court (Central District) of the State of California, and/or the United States
District Court, Central District of California, Los Angeles office, and hereby
waive any and all venue and jurisdictional objections, whether personal or
subject matter, thereto, and also consents to service of process by any means
authorized pursuant to California law.

      This Agreement shall be construed and enforced according to the laws of
the State of California applicable to agreements made to be performed wholly
within the State.

BY THEIR SIGNATURES BELOW, THE UNDERSIGNED REPRESENT THAT THEY HAVE READ THE
FOREGOING FOUR PAGES OF THIS MUTUAL AND GENERAL RELEASE OF ALL CLAIMS AND FULLY
UNDERSTAND AND AGREE TO EACH AND ALL OF THE TERMS AND CONDITIONS SET FORTH
THEREIN.

CYTRX CORPORATION                               MADISON & WALL WORLDWIDE, INC.

BY: /s/ STEVEN KRIEGSMAN                        BY: /s/ BRUCE E. ELLIOTT
    -------------------------------------           ----------------------------
      STEVEN KRIEGSMAN
                                                PRINT NAME: Bruce E. Elliott
TITLE: President
                                                TITLE: President
DATED: 6/29/04
                                                DATED: May 27, 2004

                        APPROVED AS TO FORM AND CONTENT:

WASSERMAN, COMDEN, CASSELMAN & PEARSON LLP      GREENBERG TRAURIG, P.A.

BY: /s/ CLIFFORD H. PEARSON                     BY: /s/ DAVID S. OLIVER
    --------------------------------------          ----------------------------
    CLIFFORD H. PEARSON                             DAVID S. OLIVER
Attorneys for Defendant CYTRX CORPORATION       Attorneys for Plaintiff MADISON
                                                & WALL WORLDWIDE, INC.

                                     - 4 -<PAGE>

                                                                         Ex 10.8

                          REGISTRATION RIGHTS AGREEMENT

            This Registration Rights Agreement (this "Agreement") is made and
entered into as of May __, 2004, by and between CytRx Corporation, a Delaware
corporation (the "Company"), and Madison & Wall Worldwide, Inc. ("M & W").

            WHEREAS, pursuant to that certain Mutual and General Release of All
Claims, dated as of May __, 2004, by and between the Company and M & W (the
"Mutual Release"), the Company agreed to issue 200,000 shares of its common
stock to M & W; and

            WHEREAS, pursuant to the Mutual Release, the Company agreed to
provide certain registration rights under the Securities Act of 1933, as
amended, with respect to the Common Shares (as defined below).

            NOW, THEREFORE, in consideration of the representations, warranties
and agreements contained herein and other good and valuable consideration, the
receipt and legal adequacy of which are hereby acknowledged by the parties, the
Company and M & W hereby agree as follows:

      1. Definitions.

            As used in this Agreement, the following terms shall have the
following meanings:

            "Affiliate" means, with respect to any Person, any other Person that
directly or indirectly controls or is controlled by or under common control with
such Person. For the purposes of this definition, "control," when used with
respect to any Person, means the possession, direct or indirect, of the power to
direct or cause the direction of the management and policies of such Person,
whether through the ownership of voting securities, by contract or otherwise;
and the terms "affiliated," "controlling" and "controlled" have meanings
correlative to the foregoing.

            "Blackout Period" shall have the meaning set forth in Section 3(m).

            "Board" shall have the meaning set forth in Section 3(m).

            "Business Day" means any day except Saturday, Sunday and any day
which is a legal holiday or a day on which banking institutions in the state of
California generally are authorized or required by law or other government
actions to close.

            "Commission" means the Securities and Exchange Commission.

            "Common Shares" shall have the meaning set forth in the definition
of "Registrable Securities."

            "Common Stock" means the Company's Common Stock, $.001 par value per
share.

<PAGE>

            "Effectiveness Date" means with respect to the Registration
Statement the date on which the Commission informs the Company in writing (a)
that the Commission will not review the Registration Statement, or (b) that the
Company may request the acceleration of the effectiveness of the Registration
Statement.

            "Effectiveness Period" shall have the meaning set forth in Section
2.

            "Exchange Act" means the Securities Exchange Act of 1934, as
amended.

            "Holder" means, collectively, each holder from time to time of
Registrable Securities including, without limitation, M & W and its assignees.
To the extent this Agreement refers to an election, consent, waiver, request or
approval of or by the Holder, such reference shall mean an election, consent,
waiver, request or approval by the holders of a majority in interest of the
then-outstanding Registrable Securities (on an as exercised basis).

            "Indemnified Party" shall have the meaning set forth in Section
6(c).

            "Indemnifying Party" shall have the meaning set forth in Section
6(c).

            "Losses" shall have the meaning set forth in Section 6(a).

            "NASDAQ" shall mean the NASDAQ Stock Market.

            "Person" means an individual or a corporation, partnership, trust,
incorporated or unincorporated association, joint venture, limited liability
company, joint stock company, government (or an agency or political subdivision
thereof) or other entity of any kind.

            "Proceeding" means an action, claim, suit, investigation or
proceeding (including, without limitation, an investigation or partial
proceeding, such as a deposition), whether commenced or threatened.

            "Prospectus" means the prospectus included in the Registration
Statement (including, without limitation, a prospectus that includes any
information previously omitted from a prospectus filed as part of an effective
registration statement in reliance upon Rule 430A promulgated under the
Securities Act), as amended or supplemented by any prospectus supplement, with
respect to the terms of the offering of any portion of the Registrable
Securities covered by the Registration Statement, and all other amendments and
supplements to the Prospectus, including post-effective amendments, and all
material incorporated by reference in such Prospectus.

            "Registrable Securities" means the shares of Common Stock issued or
issuable pursuant to the Mutual Release, and upon any stock split, stock
dividend, recapitalization or similar event with respect to such shares of
Common Stock and any other securities issued in exchange of or replacement of
such shares of Common Stock (collectively, the "Common Shares"); until in the
case of any of the Common Shares (a) a Registration Statement covering such
Common Share has been declared effective by the Commission and continues to be
effective during the Effectiveness Period, or (b) such Common Share is sold in
compliance with

                                      -2-
<PAGE>

Rule 144 or may be sold pursuant to Rule 144(k), after which time such Common
Share shall not be a Registrable Security.

            "Registration Statement" means the registration statement, including
the Prospectus, amendments and supplements to such registration statement or
Prospectus, including pre- and post-effective amendments, all exhibits thereto,
and all material incorporated by reference in such registration statement, for
the Shares to be filed by the Company with the Commission pursuant to Section 2
of this Agreement.

            "Rule 144" means Rule 144 promulgated by the Commission pursuant to
the Securities Act, as such Rule may be amended from time to time, or any
similar rule or regulation hereafter adopted by the Commission having
substantially the same effect as such Rule.

            "Rule 158" means Rule 158 promulgated by the Commission pursuant to
the Securities Act, as such Rule may be amended from time to time, or any
similar rule or regulation hereafter adopted by the Commission having
substantially the same effect as such Rule.

            "Rule 415" means Rule 415 promulgated by the Commission pursuant to
the Securities Act, as such Rule may be amended from time to time, or any
similar rule or regulation hereafter adopted by the Commission having
substantially the same effect as such Rule.

            "Securities Act" means the Securities Act of 1933, as amended.

            "Special Counsel" means an attorney selected by and acting as
special counsel to Holder.

      2. Registration.

            The Company shall exert its best efforts to prepare and file with
the Commission a Registration Statement, on or prior to July 13, 2004, covering
the resale of the Registrable Securities for an offering to be made on a
continuous basis pursuant to Rule 415. The Registration Statement shall be the
next new registration statement that the Company files with the Commission
(except for any registration statement on Form S-4 or Form S-8); provided,
however, that if the Registration Statement covers an underwritten offering and
the underwriter for the offering advises the Company that it is not willing to
include the Registrable Securities in the Registration Statement, the Company
shall only be obligated to include 75,000 shares of the Common Shares in the
Registration Statement and M & W shall continue to have all of the registration
rights set forth in this Section 2 as to the remaining 125,000 Common Shares.
The Registration Statement shall be on Form S-1 (except if the Company is
eligible to register for resale the Registrable Securities on any other
available form under the Securities Act, in which case such registration may be
on another appropriate form in accordance with the Securities Act and the rules
promulgated thereunder) and shall contain (except if otherwise directed by M &
W) the "Plan of Distribution" attached hereto as Exhibit A. The Company shall
pay M & W as liquidated damages $25,000 for each 30-day period during which the
Company has failed to file a Registration Statement in compliance with this
paragraph.

            The Company shall (i) use its commercially reasonable best efforts
to cause the Registration Statement to be declared effective under the
Securities Act (including filing with the

                                      -3-
<PAGE>

Commission a request for acceleration of effectiveness within five (5) Business
Days of the date that the Company is notified in writing by the Commission that
the Registration Statement will not be "reviewed," or not be subject to further
review) as soon as possible after the filing thereof, and (ii) keep such
Registration Statement continuously effective under the Securities Act for a
period of two years from the Effectiveness Date (as it may be extended
hereunder, the "Effectiveness Period").

      3. Registration Procedures; Company's Obligations.

      In connection with the registration of the Registrable Securities, the
Company shall:

            (a) Exert its commercially reasonable best efforts to prepare and
file with the Commission the Registration Statement, on or prior to the Target
Filing Date, on Form S-1 (or if the Company is eligible to register for resale
the Registrable Securities on any other available form under the Securities Act,
in which case such registration may be on another appropriate form in accordance
with the Securities Act and the rules promulgated thereunder) in accordance with
the method or methods of distribution thereof as specified by the Holder (except
if otherwise directed by the Holder), and use its commercially reasonable best
efforts to cause the Registration Statement to become effective and remain
effective as provided herein; provided, however, that not less than three (3)
Business Days prior to the filing of the Registration Statement or any related
Prospectus or any amendment or supplement thereto (including any document that
would be incorporated therein by reference), the Company shall (i) furnish to
the Holder and any Special Counsel, copies of all such documents proposed to be
filed, which documents (other than those incorporated by reference) will be
subject to the timely review of and comment by such Special Counsel, and (ii) at
the request of the Holder cause its officers and directors, counsel and
independent certified public accountants to respond to such inquiries, and to
make available for inspection by the Holder all financial and other records,
pertinent corporate documents and properties of the Company, as shall be
necessary, in the reasonable opinion of such Special Counsel, to conduct a
reasonable investigation within the meaning of the Securities Act. The Company
shall not file the Registration Statement or any such Prospectus or any
amendments or supplements thereto to which the Holder or any Special Counsel
shall reasonably object in writing within three (3) Business Days of their
receipt thereof.

            (b) (i) Prepare and file with the Commission such amendments,
including post-effective amendments, to the Registration Statement as may be
necessary to keep the Registration Statement continuously effective as to the
applicable Registrable Securities for the Effectiveness Period in order to
register for resale under the Securities Act all of the Registrable Securities;
(ii) cause the related Prospectus to be amended or supplemented by any required
Prospectus supplement, and as so supplemented or amended to be filed pursuant to
Rule 424 (or any similar provisions then in force) promulgated under the
Securities Act; (iii) respond promptly to any comments received from the
Commission with respect to the Registration Statement or any amendment thereto
and promptly provide the Holder true and complete copies of all correspondence
from and to the Commission relating to the Registration Statement; and (iv)
comply in all material respects with the provisions of the Securities Act and
the Exchange Act with respect to the disposition of all Registrable Securities
covered by the Registration Statement during the applicable period in accordance
with the intended methods of disposition

                                      -4-
<PAGE>

by the Holder set forth in the Registration Statement as so amended or in such
Prospectus as so supplemented.

            (c) Notify the Holder of Registrable Securities to be sold and any
Special Counsel promptly (and, in the case of (i)(A) below, not less than three
(3) Business Days prior to such filing and, in the case of (i)(C) below, no
later than the first Business Day following the date on which the Registration
Statement becomes effective) and (if requested by any such Person) confirm such
notice in writing no later than three (3) Business Days following the day (i)(A)
when a Prospectus or any Prospectus supplement or post-effective amendment to
the Registration Statement is proposed to be filed, (B) when the Commission
notifies the Company whether there will be a "review" of such Registration
Statement and whenever the Commission comments in writing on such Registration
Statement, and (C) with respect to the Registration Statement or any
post-effective amendment, when the same has become effective; (ii) of any
request by the Commission or any other Federal or state governmental authority
for amendments or supplements to the Registration Statement or Prospectus or for
additional information; (iii) of the issuance by the Commission of any stop
order suspending the effectiveness of the Registration Statement covering any or
all of the Registrable Securities or the initiation of any Proceedings for that
purpose; (iv) of the receipt by the Company of any notification with respect to
the suspension of the qualification or exemption from qualification of any of
the Registrable Securities for sale in any jurisdiction, or the initiation or
threatening of any Proceeding for such purpose; and (v) of the occurrence of any
event that makes any statement made in the Registration Statement or Prospectus
or any document incorporated or deemed to be incorporated therein by reference
untrue in any material respect or that requires any revisions to the
Registration Statement, Prospectus or other documents so that, in the case of
the Registration Statement or the Prospectus, as the case may be, it will not
contain any untrue statement of a material fact or omit to state any material
fact required to be stated therein or necessary to make the statements therein,
in the light of the circumstances under which they were made, not misleading.

            The Company shall promptly furnish to the Special Counsel, without
charge, (i) any correspondence from the Commission or the Commission's staff to
the Company or its representatives relating to any Registration Statement, and
(ii) promptly after the same is prepared and filed with the Commission, a copy
of any written response to the correspondence received from the Commission.

            (d) Use its commercially reasonable best efforts to avoid the
issuance of, or, if issued, obtain the withdrawal of, (i) any order suspending
the effectiveness of the Registration Statement, or (ii) any suspension of the
qualification (or exemption from qualification) of any of the Registrable
Securities for sale in any U.S. jurisdiction, at the earliest practicable
moment.

            (e) If requested by the Holder, (i) promptly incorporate in a
Prospectus supplement or post-effective amendment to the Registration Statement
such information as the Company reasonably agrees should be included therein,
and (ii) make all required filings of such Prospectus supplement or such
post-effective amendment as soon as practicable after the Company has received
notification of the matters to be incorporated in such Prospectus supplement or
post-effective amendment.

                                      -5-
<PAGE>

            (f) Furnish to the Holder and any Special Counsel, without charge,
at least one conformed copy of each Registration Statement and each amendment
thereto, including financial statements and schedules, all documents
incorporated or deemed to be incorporated therein by reference, and all exhibits
to the extent requested by such Person (including those previously furnished or
incorporated by reference) promptly after the filing of such documents with the
Commission.

            (g) Promptly deliver to the Holder and any Special Counsel, without
charge, as many copies of the Registration Statement, Prospectus or Prospectuses
(including each form of prospectus) and each amendment or supplement thereto as
such Persons may reasonably request; and the Company hereby consents to the use
of such Prospectus and each amendment or supplement thereto by the selling
Holder in connection with the offering and sale of the Registrable Securities
covered by such Prospectus and any amendment or supplement thereto.

            (h) Prior to any public offering of Registrable Securities, use its
commercially reasonable best efforts to register or qualify or cooperate with
the selling Holder and any Special Counsel in connection with the registration
or qualification (or exemption from such registration or qualification) of such
Registrable Securities for offer and sale under the securities or Blue Sky laws
of such jurisdictions within the United States as the Holder reasonably requests
in writing, to keep each such registration or qualification (or exemption
therefrom) effective during the Effectiveness Period and to do any and all other
acts or things necessary or advisable to enable the disposition in such
jurisdictions of the Registrable Securities covered by a Registration Statement;
provided, however, that the Company shall not be required to qualify generally
to do business in any jurisdiction where it is not then so qualified or to take
any action that would subject it to general service of process in any such
jurisdiction where it is not then so subject or subject the Company to any tax
in any such jurisdiction where it is not then so subject.

            (i) Cooperate with the Holder to facilitate the timely preparation
and delivery of certificates representing Registrable Securities to be sold
pursuant to a Registration Statement and to enable such Registrable Securities
to be in such denominations and registered in such names as the Holder may
request at least two (2) Business Days prior to any sale of Registrable
Securities.

            (j) Upon the occurrence of any event contemplated by Section
3(c)(v), promptly prepare a supplement or amendment, including a post-effective
amendment, to the Registration Statement or a supplement to the related
Prospectus or any document incorporated or deemed to be incorporated therein by
reference, and file any other required document so that, as thereafter
delivered, neither the Registration Statement nor such Prospectus will contain
an untrue statement of a material fact or omit to state a material fact required
to be stated therein or necessary to make the statements therein, in the light
of the circumstances under which they were made, not misleading.

            (k) Use its commercially reasonable best efforts to cause all
Registrable Securities relating to such Registration Statement to be quoted by
NASDAQ and any other securities exchange, quotation system, market or
over-the-counter bulletin board, if any, on which the same securities issued by
the Company are then listed.

                                      -6-
<PAGE>

            (l) Comply in all material respects with all applicable rules and
regulations of the Commission and make generally available to its security
holders earning statements satisfying the provisions of Section 11(a) of the
Securities Act and Rule 158 not later than forty-five (45) days after the end of
any twelve (12) month period (or ninety (90) days after the end of any twelve
(12) month period if such period is a fiscal year) commencing on the first day
of the first fiscal quarter of the Company after the effective date of the
Registration Statement, which statement shall conform to the requirements of
Rule 158.

            (m) If (i) there is material non-public information regarding the
Company which the Company's Board of Directors (the "Board") reasonably
determines not to be in the Company's best interest to disclose and which the
Company is not otherwise required to disclose, or (ii) there is a significant
business opportunity (including, but not limited to, the acquisition or
disposition of assets (other than in the ordinary course of business) or any
merger, consolidation, tender offer or other similar transaction) available to
the Company which the Board reasonably determines not to be in the Company's
best interest to disclose and which the Company would be required to disclose
under the Registration Statement, then the Company may suspend effectiveness of
a Registration Statement and suspend the sale of Registrable Securities under a
Registration Statement one (1) time every three (3) months or three (3) times in
any twelve month period, provided that the Company may not suspend its
obligation for more than sixty (60) days in the aggregate in any twelve month
period (each, a "Blackout Period"); provided, however, that no such suspension
shall be permitted for more than twenty (20) consecutive days, arising out of
the same set of facts, circumstances or transactions, and that there shall be at
least two business days between each Blackout Period; and, provided, further,
that the Effectiveness Period shall be extended by up to sixty (60) days to
reflect any Blackout Periods.

            (n) Within two (2) Business Days after the Registration Statement
which includes the Registrable Securities is ordered effective by the
Commission, the Company shall deliver, and shall cause legal counsel for the
Company to deliver, to the transfer agent for such Registrable Securities (with
copies to the Holder whose Registrable Securities are included in such
Registration Statement) confirmation that the Registration Statement has been
declared effective by the Commission in the form attached hereto as Exhibit B.

      4. Registration Procedures; Holder's Obligations

            In connection with the registration of the Registrable Securities,
the Holder shall:

            (a) If the Registration Statement refers to the Holder by name or
otherwise as the holder of any securities of the Company, have the right to
require (if such reference to the Holder by name or otherwise is not required by
the Securities Act or any similar federal statute then in force) the deletion of
the reference to the Holder in any amendment or supplement to the Registration
Statement filed or prepared subsequent to the time that such reference ceases to
be required.

            (b) (i) not sell any Registrable Securities under the Registration
Statement until it has received copies of the Prospectus as then amended or
supplemented as contemplated in Section 3(g) and notice from the Company that
such Registration Statement and any post-

                                      -7-
<PAGE>

effective amendments thereto have become effective as contemplated by Section
3(c), (ii) comply with the prospectus delivery requirements of the Securities
Act as applicable to it in connection with sales of Registrable Securities
pursuant to the Registration Statement, and (iii) furnish to the Company
information regarding such Holder and the distribution of such Registrable
Securities as is required by law to be disclosed in the Registration Statement,
and the Company may exclude from such registration the Registrable Securities of
the Holder if it fails to furnish such information within a reasonable time
prior to the filing of each Registration Statement, supplemented Prospectus
and/or amended Registration Statement.

            (c) upon receipt of a notice from the Company of the occurrence of
any event of the kind described in Section 3(c)(ii), 3(c)(iii), 3(c)(iv),
3(c)(v) or 3(m), forthwith discontinue disposition of such Registrable
Securities under the Registration Statement until the Holder's receipt of the
copies of the supplemented Prospectus and/or amended Registration Statement
contemplated by Section 3(j), or until it is advised in writing by the Company
that the use of the applicable Prospectus may be resumed, and, in either case,
has received copies of any additional or supplemental filings that are
incorporated or deemed to be incorporated by reference in such Prospectus or
Registration Statement.

      5. Registration Expenses

            All reasonable fees and expenses incident to the performance of or
compliance with this Agreement by the Company shall be borne by the Company
whether or not the Registration Statement is filed or becomes effective and
whether or not any Registrable Securities are sold pursuant to the Registration
Statement. The fees and expenses referred to in the foregoing sentence shall
include, without limitation, the following: (i) all registration and filing fees
(including, without limitation, fees and expenses (A) with respect to filings
required to be made with NASDAQ and each securities exchange or other market on
which Registrable Securities are required hereunder to be listed, (B) with
respect to filings required to be made with the Commission, and (C) in
compliance with state securities or Blue Sky laws); (ii) printing expenses
(including, without limitation, expenses of printing certificates for
Registrable Securities and of printing prospectuses if the printing of
prospectuses is requested by the holders of a majority of the Registrable
Securities included in the Registration Statement); (iii) messenger, telephone
and delivery expenses incurred by the Company; (iv) fees and disbursements of
counsel for the Company; and (v) fees and expenses of all other Persons retained
by the Company in connection with the consummation of the transactions
contemplated by this Agreement, including, without limitation, the Company's
independent public accountants (including the expenses of any comfort letters or
costs associated with the delivery by independent public accountants of a
comfort letter or comfort letters). In addition, the Company shall be
responsible for all of its internal expenses incurred in connection with the
consummation of the transactions contemplated by this Agreement (including,
without limitation, all salaries and expenses of its officers and employees
performing legal or accounting duties), the expense of any annual audit, and the
fees and expenses incurred in connection with the listing of the Registrable
Securities on any securities exchange as required hereunder. The Company shall
not be responsible for the payment of any commissions or other expenses incurred
by the Holder in connection with their sales of Registrable Securities or for
the fees of any Special Counsel.

                                      -8-
<PAGE>

      6. Indemnification

            (a) Indemnification by the Company. The Company shall,
notwithstanding any termination of this Agreement, indemnify and hold harmless M
& W, its permitted assignees, officers, directors, agents, brokers (including
brokers who offer and sell Registrable Securities as principal as a result of a
pledge or any failure to perform under a margin call of Common Stock),
investment advisors and employees, each Person who controls M & W or a permitted
assignee (within the meaning of Section 15 of the Securities Act or Section 20
of the Exchange Act) and the officers, directors, agents and employees of each
such controlling Person, and the respective successors, assigns, estate and
personal representatives of each of the foregoing, to the fullest extent
permitted by applicable law, from and against any and all claims, losses,
damages, liabilities, penalties, judgments, costs (including, without
limitation, costs of investigation) and expenses (including, without limitation,
reasonable attorneys' fees and expenses) (collectively, "Losses"), as incurred,
arising out of or relating to any untrue or alleged untrue statement of a
material fact contained in the Registration Statement, any Prospectus, as
supplemented or amended, if applicable, or arising out of or relating to any
omission or alleged omission of a material fact required to be stated therein or
necessary to make the statements therein (in the case of any Prospectus or form
of prospectus or supplement thereto, in the light of the circumstances under
which they were made) not misleading, except (i) to the extent, but only to the
extent, that such untrue statements or omissions are based solely upon
information regarding the Holder furnished in writing to the Company by the
Holder expressly for use in the Registration Statement, such Prospectus or such
form of Prospectus or in any amendment or supplement thereto, or (ii) as a
result of the failure of the Holder to deliver a Prospectus, as amended or
supplemented, to a purchaser in connection with an offer or sale (provided that
copies of the Prospectus, as amended or supplemented, have been provided to the
Holder by the Company for delivery to such purchaser). The Company shall notify
the Holder promptly of the institution, threat or assertion of any Proceeding of
which the Company is aware in connection with the transactions contemplated by
this Agreement. Such indemnity shall remain in full force and effect regardless
of any investigation made by or on behalf of an Indemnified Party (as defined in
Section 6(c) hereof) and shall survive the transfer of the Registrable
Securities by the Holder.

            (b) Indemnification by M & W. M & W and its permitted assignees
shall, jointly and severally, indemnify and hold harmless the Company, its
directors, officers, agents and employees, each Person who controls the Company
(within the meaning of Section 15 of the Securities Act and Section 20 of the
Exchange Act), and the directors, officers, agents or employees of such
controlling Persons, and the respective successors, assigns, estate and personal
representatives of each of the foregoing, to the fullest extent permitted by
applicable law, from and against any and all Losses, as incurred, arising out of
or relating to any untrue or alleged untrue statement of a material fact
contained in the Registration Statement, any Prospectus, as supplemented or
amended, if applicable, or arising out of or relating to any omission or alleged
omission of a material fact required to be stated therein or necessary to make
the statements therein (in the case of any Prospectus or form of prospectus or
supplement thereto, in the light of the circumstances under which they were
made) not misleading, to the extent, but only to the extent, that (i) such
untrue statement or omission is contained in or omitted from any information so
furnished in writing by the Holder or the Special Counsel to the Company
specifically for inclusion in the Registration Statement or such Prospectus, and
(ii) such

                                      -9-
<PAGE>

information was reasonably relied upon by the Company for use in the
Registration Statement, such Prospectus or such form of prospectus or, to the
extent that such information relates to the Holder or the Holder's proposed
method of distribution of Registrable Securities, was reviewed and expressly
approved in writing by the Holder expressly for use in the Registration
Statement, such Prospectus or such form of Prospectus Supplement.
Notwithstanding anything to the contrary contained herein, the Holder shall be
liable under this Section 6(b) for only that amount as does not exceed the net
proceeds to the Holder as a result of the sale of Registrable Securities
pursuant to such Registration Statement.

            (c) Conduct of Indemnification Proceedings. If any Proceeding shall
be brought or asserted against any Person entitled to indemnity pursuant to
Section 6(a) or 6(b) hereunder (an "Indemnified Party"), such Indemnified Party
promptly shall notify the Person from whom indemnity is sought (the
"Indemnifying Party) in writing, and the Indemnifying Party shall assume the
defense thereof, including the employment of counsel reasonably satisfactory to
the Indemnified Party and the payment of all fees and expenses incurred in
connection with defense thereof; provided, that the failure of any Indemnified
Party to give such notice shall not relieve the Indemnifying Party of its
obligations or liabilities pursuant to this Agreement, except (and only) to the
extent that it shall be finally determined by a court of competent jurisdiction
(which determination is not subject to appeal or further review) that such
failure shall have materially and adversely prejudiced the Indemnifying Party.

            An Indemnified Party shall have the right to employ separate counsel
in any such Proceeding and to participate in the defense thereof, but the fees
and expenses of such counsel shall be at the expense of such Indemnified Party
or Parties unless: (i) the Indemnifying Party has agreed in writing to pay such
fees and expenses; or (ii) the Indemnifying Party shall have failed promptly to
assume the defense of such Proceeding and to employ counsel reasonably
satisfactory to such Indemnified Party in any such Proceeding; or (iii) the
named parties to any such Proceeding (including any impleaded parties) include
both such Indemnified Party and the Indemnifying Party, and such Indemnified
Party shall have been advised by counsel that a conflict of interest is likely
to exist if the same counsel were to represent such Indemnified Party and the
Indemnifying Party (in which case, if such Indemnified Party notifies the
Indemnifying Party in writing that it elects to employ separate counsel at the
expense of the Indemnifying Party, the Indemnifying Party shall not have the
right to assume the defense thereof and such counsel shall be at the expense of
the Indemnifying Party). The Indemnifying Party shall not be liable for any
settlement of any such Proceeding effected without its written consent, which
consent shall not be unreasonably withheld, conditioned or delayed. No
Indemnifying Party shall, without the prior written consent of the Indemnified
Party, which consent shall not unreasonably be withheld, conditioned or delayed,
effect any settlement of any pending Proceeding in respect of which any
Indemnified Party is a party, unless such settlement includes an unconditional
release of such Indemnified Party from all liability on claims that are the
subject matter of such Proceeding.

            All reasonable fees and expenses of the Indemnified Party (including
reasonable fees and expenses to the extent incurred in connection with
investigating or preparing to defend such Proceeding in a manner not
inconsistent with this Section) shall be paid to the Indemnified Party, as
incurred, within ten (10) Business Days of written notice thereof to the
Indemnifying Party (regardless of whether it is ultimately determined that an
Indemnified Party is not entitled

                                      -10-
<PAGE>

to indemnification hereunder; provided, that the Indemnifying Party may require
such Indemnified Party to undertake to reimburse all such fees and expenses to
the extent it is finally judicially determined that such Indemnified Party is
not entitled to indemnification hereunder or pursuant to applicable law).

            (d) Contribution. If a claim for indemnification under Section 6(a)
or 6(b) is unavailable to an Indemnified Party because of a failure or refusal
of a governmental authority to enforce such indemnification in accordance with
its terms (by reason of public policy or otherwise), then each Indemnifying
Party, in lieu of indemnifying such Indemnified Party, shall contribute to the
amount paid or payable by such Indemnified Party as a result of such Losses, in
such proportion as is appropriate to reflect the relative fault of the
Indemnifying Party and Indemnified Party in connection with the actions,
statements or omissions that resulted in such Losses as well as any other
relevant equitable considerations. The relative fault of such Indemnifying Party
and Indemnified Party shall be determined by reference to, among other things,
whether any action in question, including any untrue or alleged untrue statement
of a material fact or omission or alleged omission of a material fact, has been
taken or made by, or relates to information supplied by, such Indemnifying Party
or Indemnified Party, and the parties' relative intent, knowledge, access to
information and opportunity to correct or prevent such action, statement or
omission. The amount paid or payable by a party as a result of any Losses shall
be deemed to include, subject to the limitations set forth in Section 6(c), any
reasonable attorneys' or other reasonable fees or expenses incurred by such
party in connection with any Proceeding to the extent such party would have been
indemnified for such fees or expenses if the indemnification provided for under
Section 6(a) or 6(b) was available to such party in accordance with its terms.
Notwithstanding anything to the contrary contained herein, the Holder shall be
liable or required to contribute under this Section 6(d) for only that amount as
does not exceed the net proceeds to the Holder as a result of the sale of
Registrable Securities pursuant to the Registration Statement.

            The parties hereto agree that it would not be just and equitable if
contribution pursuant to this Section 6(d) were determined by pro rata
allocation or by any other method of allocation that does not take into account
the equitable considerations referred to in the immediately preceding paragraph.
No Person guilty of fraudulent misrepresentation (within the meaning of Section
11(f) of the Securities Act) shall be entitled to contribution from any Person
who was not guilty of such fraudulent misrepresentation.

            The indemnity and contribution agreements contained in this Section
are in addition to any liability that the Indemnifying Parties may have to the
Indemnified Parties.

      7. Rule 144.

            As long as the Holder owns Registrable Securities, the Company
covenants to timely file (or obtain extensions in respect thereof and file
within the applicable grace period) all reports required to be filed by the
Company after the date hereof pursuant to Section 13(a) or 15(d) of the Exchange
Act and to promptly furnish the Holder with true and complete copies of all such
filings. As long as the Holder owns Registrable Securities, if the Company is
not required to file reports pursuant to Section 13(a) or 15(d) of the Exchange
Act, it will prepare and furnish to the Holder and make publicly available in
accordance with Rule 144(c)

                                      -11-
<PAGE>

promulgated under the Securities Act annual and quarterly financial statements,
together with a discussion and analysis of such financial statements in form and
substance substantially similar to those that would otherwise be required to be
included in reports required by Section 13(a) or 15(d) of the Exchange Act, as
well as any other information required thereby, in the time period that such
filings would have been required to have been made under the Exchange Act. The
Company further covenants that it will take such further action as the Holder
may reasonably request, all to the extent required from time to time to enable
the Holder to sell the Common Shares without registration under the Securities
Act within the limitation of the exemptions provided by Rule 144 promulgated
under the Securities Act. Upon the request of any Holder, the Company shall
deliver to such Holder a written certification of a duly authorized officer as
to whether it has complied with such requirements.

      8. Miscellaneous.

            (a) Remedies. In the event of a breach by the Company or by the
Holder of any of their obligations under this Agreement, the Holder or the
Company, as the case may be, in addition to being entitled to exercise all
rights granted by law and under this Agreement, including recovery of damages,
will be entitled to specific performance of its rights under this Agreement. The
Company and the Holder each agree that monetary damages would not provide
adequate compensation for any losses incurred by reason of a breach by it of any
of the provisions of this Agreement and hereby further each agree that, in the
event of any action for specific performance in respect of such breach, it shall
waive the defense that a remedy at law would be adequate.

            (b) No Inconsistent Agreements. Neither the Company nor any of its
Affiliates has as of the date hereof entered into, nor shall the Company or any
of its Affiliates, on or after the date of this Agreement, enter into, any
agreement with respect to its securities that is inconsistent with the rights
granted to the Holder in this Agreement or otherwise conflicts with the
provisions hereof. Without limiting the generality of the foregoing, without the
written consent of the Holder, the Company shall not grant to any Person the
right to request the Company to register any securities of the Company under the
Securities Act if the rights so granted are inconsistent with the rights granted
to the Holder set forth herein, or otherwise prevent the Company with complying
with all of its obligations hereunder.

            (c) No Piggyback on Registrations. Neither the Company nor any of
its security holders (other than the Holder in such capacity pursuant hereto)
may include securities of the Company in the Registration Statement; provided,
however, that securities held by other security holders, the resale of which the
Company is contractually obligated to register under the Securities Act, may be
included in the Registration Statement.

            (d) Consent to Jurisdiction. The Company and M & W (i) hereby
irrevocably submit to the non-exclusive jurisdiction of the United States
District Court for the Central District of California and the courts of the
State of California located in the City of Los Angeles, California, for the
purposes of any suit, action or proceeding arising out of or relating to this
Agreement, and (ii) hereby waive, and agree not to assert in any such suit,
action or proceeding, any claim that it is not personally subject to the
jurisdiction of such court, that the suit, action or proceeding is brought in an
inconvenient forum or that the venue of the suit, action or proceeding

                                      -12-
<PAGE>

is improper. The Company and M & W consent to process being served in any such
suit, action or proceeding by mailing a copy thereof to such party at the
address in effect for notices to it under this Agreement and agrees that such
service shall constitute good and sufficient service of process and notice
thereof. Nothing in this Section 8(d) shall affect or limit any right to serve
process in any other manner permitted by law.

            (e) Amendments and Waivers. The provisions of this Agreement,
including the provisions of this sentence, may not be amended, modified or
supplemented, and waivers or consents to departures from the provisions hereof
may not be given, unless the same shall be in writing and signed by the Company
and M & W.

            (f) Notices. Any and all notices or other communications or
deliveries required or permitted to be provided hereunder shall be in writing
and shall be deemed given and effective on the earlier of (i) the date of
transmission, if such notice or communication is delivered via facsimile at the
facsimile telephone number specified for notice prior to 5:00 p.m., Pacific
Time, on a Business Day, (ii) the first Business Day after the date of
transmission, if such notice or communication is delivered via facsimile at the
facsimile telephone number specified for notice later than 5:00 p.m., Pacific
Time, on any date and earlier than 11:59 p.m., Pacific Time, on such date, (iii)
the Business Day following the date of mailing, if sent by nationally recognized
overnight courier service, or (iv) actual receipt by the party to whom such
notice is required to be given.

                  (x) if to the Company:

                      CytRx Corporation
                      11726 San Vicente Boulevard, Suite 650
                      Los Angeles, California  90049
                      Attention:  Steven A. Kriegsman
                      Telecopier:  (310) 826-5529
                      Telephone:  (310) 826-5648

                      with a copy to:

                      Troy & Gould Professional Corporation
                      1801 Century Park East, 16th Floor
                      Los Angeles, California  90067-2367
                      Attention:  Sanford J. Hillsberg
                      Telecopier: (310) 201-4746
                      Telephone: (310) 553-4441

                                      -13-
<PAGE>

                  (y) if to M & W:

                      Madison & Wall Worldwide, Inc.
                      195 Wekiva Springs Road, Suite 200
                      Longwood, Florida 32771
                      Attention:  Bruce Elliot
                      Telecopier: (407) 682-2544
                      Telephone: (407) 682-2001

                      with a copy to:

                      Greenberg Taurig, P.A.
                      450 South Orange Avenue, Suite 650
                      Orlando, Florida  32801
                      Attention:  David S. Oliver
                      Telecopier: (407) 420-5909
                      Telephone: (407) 420-1000

or to such other address or addresses or facsimile number or numbers as any such
party may most recently have designated in writing to the other parties hereto
by such notice.

            (g) Successors and Assigns. This Agreement shall be binding upon and
inure to the benefit of the parties and their successors and permitted assigns.

            (h) Assignment of Registration Rights. The rights of the Holder
hereunder, including the right to have the Company register for resale
Registrable Securities in accordance with the terms of this Agreement, shall be
assignable by each Holder to any transferee of the Holder of all or a portion of
the shares of Registrable Securities if: (i) the Holder agrees in writing with
the transferee or assignee to assign such rights, and a copy of such agreement
is furnished to the Company within a reasonable time after such assignment; (ii)
the Company is, within a reasonable time after such transfer or assignment,
furnished with written notice of (A) the name and address of such transferee or
assignee, and (B) the securities with respect to which such registration rights
are being transferred or assigned; (iii) following such transfer or assignment
the further disposition of such securities by the transferee or assignees is
restricted under the Securities Act and applicable state securities laws; and
(iv) at or before the time the Company receives the written notice contemplated
by clause (ii) of this Section, the transferee or assignee agrees in writing
with the Company to be bound by all of the provisions of this Agreement. In
addition, the Holder shall have the right to assign its rights hereunder to any
other Person with the prior written consent of the Company, which consent shall
not be unreasonably withheld, conditioned or delayed. The rights to assignment
shall apply to the Holder (and to subsequent) successors and assigns. In the
event of an assignment pursuant to this Section 8(h), M & W shall pay all
incremental costs and expenses incurred by the Company in connection with filing
a Registration Statement (or an amendment to the Registration Statement) to
register the shares of Registrable Securities assigned to any assignee or
transferee of M & W.

            (i) Counterparts. This Agreement may be executed in any number of
counterparts, each of which when so executed shall be deemed to be an original,
and all of which

                                      -14-
<PAGE>

taken together shall constitute one and the same Agreement. In the event that
any signature is delivered by facsimile transmission, such signature shall
create a valid binding obligation of the party executing (or on whose behalf
such signature is executed) the same with the same force and effect as if such
facsimile signature were the original thereof.

            (j) Governing Law. This Agreement shall be governed by and construed
in accordance with the laws of the State of Delaware, without regard to
principles of conflicts of law thereof. This Agreement shall not be interpreted
or construed with any presumption against the party causing this Agreement to be
drafted.

            (k) Cumulative Remedies. The remedies provided herein are cumulative
and not exclusive of any remedies provided by law.

            (l) Termination. This Agreement shall terminate on the date on which
all of the Registrable Securities may be sold without restriction pursuant to
Rule 144(k) of the Securities Act.

            (m) Severability. If any term, provision, covenant or restriction of
this Agreement is held to be invalid, illegal, void or unenforceable in any
respect, the remainder of the terms, provisions, covenants and restrictions set
forth herein shall remain in full force and effect and shall in no way be
affected, impaired or invalidated, and the parties hereto shall use their
reasonable efforts to find and employ an alternative means to achieve the same
or substantially the same result as that contemplated by such term, provision,
covenant or restriction. It is hereby stipulated and declared to be the
intention of the parties that they would have executed the remaining terms,
provisions, covenants and restrictions without including any of such that may be
hereafter declared invalid, illegal, void or unenforceable.

            (n) Headings. The headings herein are for convenience only, do not
constitute a part of this Agreement and shall not be deemed to limit or affect
any of the provisions hereof.

            (o) Investment Intent. M&W has acquired the Registrable Securities
for its own account for the purpose of investment and not with a view to or for
sale in connection with the distribution thereof. M&W acknowledges and agrees
that the certificate(s) issued to evidence the Registrable Securities shall bear
a restrictive legend under the Securities Act in substantially the form set
forth in Exhibit C hereto. The Company agrees to remove this restrictive legend
upon any transfer of the Registrable Securities in accordance with the terms of
the restrictive legend or pursuant to an effective Registration Statement and in
compliance with the terms of this Agreement.

                            (signature page follows)

                                      -15-
<PAGE>

            IN WITNESS WHEREOF, the parties hereto have caused this Agreement to
be duly executed by their respective authorized persons as of the date first
indicated above.

                                        CYTRX CORPORATION

                                        By:  /s/ STEVEN A. KRIEGSMAN
                                          --------------------------------------
                                          Name:  Steven A. Kriegsman
                                          Title: President and Chief Executive
                                                 Officer

                                        MADISON & WALL WORLDWIDE, INC.

                                        By:  /s/ BRUCE ELLIOT
                                          --------------------------------------
                                          Name:  Bruce Elliot
                                          Title: Chief Executive Officer and
                                                 Chief Financial Officer

<PAGE>

                                    EXHIBIT A

                              PLAN OF DISTRIBUTION

      We are registering the shares of common stock on behalf of the selling
stockholders. The common stock may be sold in one or more transactions at fixed
prices, at prevailing market prices at the time of sale, at prices related to
the prevailing market prices, at varying prices determined at the time of sale,
or at negotiated prices. These sales may be effected at various times in one or
more of the following transactions, or in other kinds of transactions:

      -     transactions on the NASDAQ Stock Market or on any national
            securities exchange or U.S. inter-dealer system of a registered
            national securities association on which the common stock may be
            listed or quoted at the time of sale;

      -     in the over-the-counter market;

      -     in private transactions and transactions otherwise than on these
            exchanges or systems or in the over-the-counter market;

      -     in connection with short sales of the shares;

      -     by pledge to secure or in payment of debt and other obligations;

      -     through the writing of options, whether the options are listed on an
            options exchange or otherwise;

      -     in connection with the writing of non-traded and exchange-traded
            call options, in hedge transactions and in settlement of other
            transactions in standardized or over-the-counter options; or

      -     through a combination of any of the above transactions.

      The selling stockholders and their successors, including their
transferees, pledgees or donees or their successors, may sell the common stock
directly to purchasers or through underwriters, broker-dealers or agents, who
may receive compensation in the form of discounts, concessions or commissions
from the selling stockholders or the purchasers. These discounts, concessions or
commissions as to any particular underwriter, broker-dealer or agent may be in
excess of those customary in the types of transactions involved.

      The selling stockholders also may engage in short sales against the box,
puts and calls and other transactions in our securities or derivatives of our
securities and may sell or deliver shares in connection with these trades.

                                       A-1
<PAGE>

      In addition, any securities covered by this prospectus which qualify for
sale pursuant to Rule 144 of the Securities Act may be sold under Rule 144
rather than pursuant to this prospectus.

      The selling stockholders may from time to time pledge or grant a security
interest in some or all of the shares of common stock owned by them and, if they
default in the performance of their secured obligations, the pledgees or secured
parties may offer and sell the shares of common stock from time to time under
this prospectus after we have filed an amendment to this prospectus under Rule
424(b)(3) or other applicable provision of the Securities Act amending the list
of selling stockholders to include the pledgee, transferee or other successors
in interest as selling stockholders under this prospectus.

      The selling stockholders also may transfer the shares of common stock in
other circumstances, in which case the transferees, pledgees or other successors
in interest will be the selling beneficial owners for purposes of this
prospectus and may sell the shares of common stock from time to time under this
prospectus after we have filed an amendment to this prospectus under Rule
424(b)(3) or other applicable provision of the Securities Act amending the list
of selling stockholders to include the pledgee, transferee or other successors
in interest as selling stockholders under this prospectus.

      The selling stockholders and any broker-dealers or agents that are
involved in selling the shares of common stock may be deemed to be
"underwriters" within the meaning of the Securities Act in connection with such
sales. In such event, any commissions received by such broker-dealers or agents
and any profit on the resale of the shares of common stock purchased by them may
be deemed to be underwriting commissions or discounts under the Securities Act.

      We entered into a registration rights agreement for the benefit of the
selling stockholders to register the common stock under applicable federal and
state securities laws. The registration rights agreement provides for
cross-indemnification of the selling stockholders and us and our respective
directors, officers and controlling persons against specific liabilities in
connection with the offer and sale of the common stock, including liabilities
under the Securities Act. We will pay substantially all of the expenses incurred
by the selling stockholders incident to the registration of the common stock.

      The selling stockholders have advised us that they have not entered into
any agreements, understandings or arrangements with any underwriters or
broker-dealers regarding the sale of their shares of common stock, nor is there
an underwriter or coordinating broker acting in connection with a proposed sale
of shares of common stock by any selling stockholder. If we are notified by any
selling stockholder that any material arrangement has been entered into with a
broker-dealer for the sale of shares of common stock, if required, we will file
a supplement to this prospectus. If the selling stockholders use this prospectus
for any sale of the shares of common stock, they will be subject to the
prospectus delivery requirements of the Securities Act.

      The anti-manipulation rules of Regulation M under the Securities Exchange
Act may apply to sales of our common stock and activities of the selling
stockholders.

                                      A-2

<PAGE>

                                    EXHIBIT B

                         FORM OF NOTICE OF EFFECTIVENESS
                            OF REGISTRATION STATEMENT

[Name and address of Transfer Agent]

____________________

____________________

____________________
Attn: ______________

                  Re: CytRx Corporation

Ladies and Gentlemen:

      We are counsel to CytRx Corporation, a Delaware corporation (the
"COMPANY"), and have represented the Company in connection with that certain
Mutual and General Release of All Claims dated as of May __, 2004 (the "MUTUAL
RELEASE"), by and between the Company and Madison & Wall Worldwide, Inc. ("M &
W"), pursuant to which the Company issued to M & W shares (the "SHARES") of its
Common Stock, $0.001 par value. Pursuant to the Mutual Release, the Company has
also entered into a Registration Rights Agreement with M & W (the "REGISTRATION
RIGHTS AGREEMENT"), dated as of May __, 2004, pursuant to which the Company
agreed, among other things, to register the Registrable Securities (as defined
in the Registration Rights Agreement), including the Shares, under the
Securities Act of 1933, as amended (the "1933 ACT"). In connection with the
Company's obligations under the Registration Rights Agreement, on _________ __,
2004, the Company filed a Registration Statement on Form S-3 (File No.
333-________) (the "REGISTRATION STATEMENT") with the Securities and Exchange
Commission (the "SEC") relating to the resale of the Registrable Securities
which names M & W as selling stockholder thereunder.

      In connection with the foregoing, we advise you that a member of the SEC's
staff has advised us by telephone that the SEC has entered an order declaring
the Registration Statement effective under the 1933 Act at [ENTER TIME OF
EFFECTIVENESS] on [ENTER DATE OF EFFECTIVENESS] and we have no knowledge, after
telephonic inquiry of a member of the SEC's staff, that any stop order
suspending its effectiveness has been issued or that any proceedings for that
purpose are pending before, or threatened by, the SEC and, accordingly, the
Registrable Securities are available for resale under the 1933 Act in the manner
specified in, and pursuant to the terms of, the Registration Statement.

                                        Very truly yours,

                                        By:

                                      B-1

<PAGE>

                                    EXHIBIT C

                               CERTIFICATE LEGEND

      Each certificate representing the Registrable Shares shall be stamped or
otherwise imprinted with a legend substantially in the following form:

      THE SECURITIES REPRESENTED BY THIS CERTIFICATE (THE "SECURITIES") HAVE NOT
      BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE
      "SECURITIES ACT") OR ANY STATE SECURITIES LAWS AND MAY NOT BE SOLD,
      TRANSFERRED OR OTHERWISE DISPOSED OF UNLESS REGISTERED UNDER THE
      SECURITIES ACT AND UNDER APPLICABLE STATE SECURITIES LAWS OR CYTRX
      CORPORATION SHALL HAVE RECEIVED AN OPINION OF ITS COUNSEL THAT
      REGISTRATION OF SUCH SECURITIES UNDER THE SECURITIES ACT AND UNDER THE
      PROVISIONS OF APPLICABLE STATE SECURITIES LAWS IS NOT REQUIRED.

                                      C-1

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00070-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00070-of-00352.parquet"}]]