Document:

Stock Option Agreement

 Exhibit 10.3 
 DIADEXUS, INC. STOCK OPTION AGREEMENT 
  
 diaDexus, Inc., a Delaware corporation (the “Company”) hereby grants to the holder listed below (“Optionee”), an option to purchase the number of shares of
the Company’s Common Stock set forth below (the “Option”), subject to all of the terms and conditions of this Stock Option Agreement (“Agreement”). 

ARTICLE 1 GRANT NOTICE 
  

			
	Optionee:	  	Brian E. Ward
		
	Grant Date:	  	September 26, 2011
		
	Exercise Price per Share:	  	$0.25
		
	Total Exercise Price:	  	$382,500
		
	Total Number of Shares
Subject to the Option:	  	1,530,000 shares
		
	Expiration Date:	  	September 25, 2021
		
	Type of Option:	  	This Option is a Nonstatutory Option and is not intended to qualify as an incentive stock option within the meaning of Section 422 of the Internal Revenue Code of 1986, as
amended (the “Code”).
	Vesting Schedule:	  	The shares subject to this Option shall vest according to the following schedule: 255,000 shares subject to the Option shall vest on July 1, 2012 and 1/36th of the remaining shares subject to the Option shall vest monthly
thereafter so that one hundred percent (100%) of the shares subject to the Option are vested on July 1, 2015.
		  	As set forth in Section 4.1 of this Agreement, the Option may become fully vested and exercisable with respect to all shares of Common Stock covered thereby in accordance
with terms set forth in a written agreement between the Company and Optionee, as otherwise permitted by this Agreement or as otherwise provided by the Administrator.
	Termination Period:	  	This Option may be exercised to the extent vested as set forth in this Agreement, but in no event later than the Expiration Date as set forth above

 ARTICLE 2 GENERAL 
 2.1 Defined Terms. Wherever the following terms are used in this Agreement they shall have the meanings specified below, unless the context clearly indicates otherwise. 

 

	 	(a)    “Common	Stock” means the common stock of the Company, par value $0.01 per share. 

  
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	 	(b)    “Change	in Control” shall mean and include each of the following: 

 

	 	(i)	A transaction or series of transactions (other than an offering of Common Stock to the general public through a registration statement filed with the Securities and
Exchange Commission) whereby any “person” or related “group” of “persons” (as such terms are used in Sections 13(d) and 14(d)(2) of the Securities Exchange Act of 1934, as amended (the “Exchange
Act”) (other than the Company, any of its Subsidiaries, an employee benefit plan maintained by the Company or any of its subsidiaries or a “person” that, prior to such transaction, directly or indirectly controls, is
controlled by, or is under common control with, the Company) directly or indirectly acquires beneficial ownership (within the meaning of Rule 13d-3 under the Exchange Act) of securities of the Company possessing more than 50% of the total combined
voting power of the Company’s securities outstanding immediately after such acquisition; provided, however, any change in the beneficial ownership of the securities of the Company as a result of a private financing of the Company that is
approved by the Board of Directors of the Company (the “Board”) shall not be deemed to be a Change in Control; or 

  

	 	(ii)	During any period of two consecutive years, individuals who, at the beginning of such period, constitute the Board together with any new director(s) (other than a
director designated by a person who shall have entered into an agreement with the Company to effect a transaction described in Section 2.1(b)(i) or Section 2.1(b)(iii)) whose election by the Board or nomination for election by the
Company’s stockholders was approved by a vote of at least a majority of the directors then still in office who either were directors at the beginning of the two-year period or whose election or nomination for election was previously so
approved, cease for any reason to constitute a majority thereof; or 

  

	 	(iii)	The consummation by the Company (whether directly involving the Company or indirectly involving the Company through one or more intermediaries) of (x) a merger,
consolidation, reorganization, or business combination or (y) a sale or other disposition of all or substantially all of the Company’s assets in any single transaction or series of related transactions or (z) the acquisition of assets
or stock of another entity, in each case other than a transaction: 

  

	 	(A)	Which results in the Company’s voting securities outstanding immediately before the transaction continuing to represent (either by remaining outstanding or by
being converted into voting securities of the Company or the person that, as a result of the transaction, controls, directly or indirectly, the Company or owns, directly or indirectly, all or substantially all of the Company’s assets or
otherwise succeeds to the business of the Company (the Company or such person, the “Successor Entity”)) directly or indirectly, at least a majority of the combined voting power of the Successor Entity’s outstanding voting
securities immediately after the transaction, and 

  

	 	(B)	After which no person or group beneficially owns voting securities representing 50% or more of the combined voting power of the Successor Entity; provided, however,
that no person or group shall be treated for purposes of this Section 2.1(b)(iii)(B) as beneficially owning 50% or more of combined voting power of the Successor Entity solely as a result of the voting power held in the Company prior to the
consummation of the transaction; or 

  

	 	(C)	The Company’s stockholders approve a liquidation or dissolution of the Company. 

The Administrator shall have full and final authority, which shall be exercised in its sole discretion, to determine conclusively whether
a Change in Control has occurred pursuant to the 

  
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above definition, and the date of the occurrence of such Change in Control and any incidental matters relating thereto. 

 

	 	(c)    “Disability”	shall mean any physical, mental or other health condition which substantially impairs the Optionee’s ability to perform his or her assigned duties for one hundred
twenty (120) days or more in any two hundred forty (240) day period or that can be expected to result in death. 

  

	 	(d)    “Grant	Notice” shall mean Article 1 of this Agreement. 

  

	 	(e)    “Optionee”	shall mean the individual identified as such in the Grant Notice. 

  

	 	(f)    “Subsidiary”	means any corporation (or other entity), whether now or hereafter existing (other than the Company), in an unbroken chain of corporations (or other entities) beginning
with the Company if each of the corporations (or other entities) other than the last corporation (or other entity) in the unbroken chain owns stock possessing more than fifty percent (50%) of the total combined voting power of all classes of
stock in one of the other corporations (or other entities) in such chain. 

  

	 	(g)    “Termination	of Consultancy” shall mean the time when the engagement of Optionee as a consultant to the Company or a Subsidiary is terminated for any reason, with
or without cause, including, but not by way of limitation, by resignation, discharge, death, Disability or retirement, but excluding: (i) terminations where there is a simultaneous employment or continuing employment of Optionee by the Company
or any Subsidiary, (ii) terminations where there is a simultaneous re-establishment of a consulting relationship or continuing consulting relationship between Optionee and the Company or any Subsidiary and (iii) terminations where there is
a simultaneous establishment or re-establishment of a director relationship or continuing director relationship between Optionee and the Company or any Subsidiary. The Board or, to the extent delegated to it by the Board, the Compensation Committee
of the Board (either the Board or, if delegated, the Compensation Committee, the “Administrator”), in its absolute discretion, shall determine the effect of all matters and questions relating to Termination of Consultancy,
including, but not by way of limitation, the question of whether a particular leave of absence constitutes a Termination of Consultancy. The Company or any Subsidiary has an absolute and unrestricted right to terminate a consultant’s service at
any time for any reason whatsoever, with or without cause, except to the extent expressly provided otherwise in writing. 

  

	 	(h)    “Termination	of Directorship” shall mean the time when the engagement of Optionee as a member of the Board of Directors of the Company or a Subsidiary is
terminated for any reason, including, without limitation, a termination by resignation, failure to be elected, death or retirement, but excluding: (i) terminations where there is a simultaneous employment or continuing employment of Optionee by
the Company or any Subsidiary, (ii) terminations where there is a simultaneous establishment or re-establishment of a consulting relationship or continuing consulting relationship between Optionee and the Company or any Subsidiary and
(iii) terminations where there is a simultaneous re-establishment of a director relationship or continuing director relationship between Optionee and the Company or any Subsidiary. The Administrator, in its sole and absolute discretion, shall
determine the effect of all matters and questions relating to Termination of Directorship. 

  

	 	(i)    	 “Termination of Employment” shall mean the time when the employee-employer relationship between Optionee and the Company or any
Subsidiary is terminated for any reason, with or without cause, including, but not by way of limitation, a termination by resignation, discharge, death, Disability or retirement; but excluding: (i) terminations where there is a simultaneous

  
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reemployment or continuing employment of Optionee by the Company or any Subsidiary, (ii) terminations where there is a simultaneous establishment or re-establishment of a consulting
relationship or continuing consulting relationship between Optionee and the Company or any Subsidiary and (iii) terminations where there is a simultaneous establishment or re-establishment of a director relationship or continuing director
relationship between Optionee and the Company or any Subsidiary. The Administrator, in its absolute discretion, shall determine the effect of all matters and questions relating to Termination of Employment, including, but not by way of limitation,
the question of whether a particular leave of absence constitutes a Termination of Employment. 

  

	 	(j)    “Termination	of Services” shall mean Optionee’s Termination of Consultancy, Termination of Directorship or Termination of Employment, as applicable.

 ARTICLE 3 GRANT OF OPTION 
 3.1     Grant of Option. In consideration of Optionee’s past and/or continued employment with or service to the Company or a Subsidiary and for other good and valuable
consideration, effective as of the Grant Date set forth in the Grant Notice (the “Grant Date”), the Company grants to Optionee the Option to purchase any part or all of an aggregate of the number of shares of Common Stock set
forth in the Grant Notice, upon the terms and conditions set forth in this Agreement, subject to adjustments as provided in Section 6.2 of this Agreement. This option is intended to be a Nonstatutory Option, as provided in the Grant Notice.

 3.2     Exercise Price. The exercise price of the shares of Common Stock subject to the Option shall be as set
forth in the Grant Notice, without commission or other charge; provided, however, that the price per share of the shares of Common Stock subject to the Option shall not be less than 100% of the Fair Market Value of a share of Common
Stock on the Grant Date. For the purposes of this Agreement, “Fair Market Value” shall mean the value of a share of Common Stock on the Grant Date which shall be the closing trading price for such date or, if there is no
closing trading price for a share of Common Stock on such date, the closing trading price for a share of Common Stock on the last preceding date for which such information exists, as reported in The Wall Street Journal or such other source as the
Administrator deems reliable. 
 3.3     Consideration to the Company. In consideration of the grant of the Option by
the Company, Optionee agrees to render faithful and efficient services to the Company or any Subsidiary. Nothing in this Agreement shall confer upon Optionee any right to continue in the employ or service of the Company or any Subsidiary or shall
interfere with or restrict in any way the rights of the Company and its Subsidiaries, which rights are hereby expressly reserved, to discharge or terminate the services of Optionee at any time for any reason whatsoever, with or without cause, except
to the extent expressly provided otherwise in a written agreement between the Company or a Subsidiary and Optionee. 
 ARTICLE
4 
 PERIOD OF EXERCISABILITY 
 4.1     Commencement of Exercisability. 
  

	 	(a)	Subject to Sections 4.2, 4.3, 6.11 and 6.15 hereof, the Option shall become vested and exercisable in such amounts and at such times as are set forth in the Grant
Notice. 

  
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	 	(b)	No portion of the Option which has not become vested and exercisable at the date of Optionee’s Termination of Services shall thereafter become vested and
exercisable, except as may be otherwise provided by the Administrator or as set forth in a written agreement between the Company and Optionee. 

  

	 	(c)	The Option shall be subject to such accelerated vesting as may be provided in a written agreement between Optionee and the Company or as otherwise provided herein.

 4.2     Duration of Exercisability. The installments provided for in the vesting schedule set forth
in the Grant Notice are cumulative. Each such installment which becomes vested and exercisable pursuant to the vesting schedule set forth in the Grant Notice shall remain vested and exercisable until it becomes unexercisable under Section 4.2
hereof. The vesting of the Option may be accelerated by the Administrator at such times and in such amounts as it shall determine in its sole discretion, as otherwise provided for in this Agreement or as set forth in a written agreement between the
Company and Optionee. 
 4.3     Expiration of Option. The Option may not be exercised to any extent by anyone, and
the Option shall terminate, to the extent not previously exercised, after the first to occur of the following events: 
  

	 	(a)	The Expiration Date set forth in the Grant Notice, which shall in no event be more than ten (10) years from the Grant Date; 

 

	 	(b)	The expiration of three (3) months from the date of Optionee’s Termination of Services, unless such termination occurs by reason of Optionee’s death or
Disability or the exercise period is extended by the Administrator until a date not later than the Expiration Date of the Option; or 

  

	 	(c)	The expiration of one (1) year from the date of Optionee’s Termination of Services by reason of Optionee’s death or Disability unless, the exercise
period is extended by the Administrator until a date not later than the Expiration Date of the Option. The Administrator shall determine whether an Optionee has incurred a Disability on the basis of medical evidence acceptable to the Administrator.
Upon making a determination of Disability, the Administrator shall, for purposes of this Agreement, determine the date of an Optionee’s termination of employment or contractual relationship. 

 

	 	(d)	The date of an Optionee’s Termination of Services for cause (as determined in the sole discretion of the Administrator). 

Unvested Options shall terminate immediately upon Optionee’s Termination of Services. 

ARTICLE 5 EXERCISE OF OPTION 
 5.1     Person Eligible to Exercise. During the lifetime of Optionee, only Optionee may exercise the Option or any portion thereof. After the death of Optionee, any exercisable
portion of the Option may, prior to the time when the Option becomes unexercisable under Section 4.2 hereof, be exercised by Optionees’s personal representative or by any person empowered to do so under the deceased Optionees’s will
or under the then applicable laws of descent and distribution. 
 5.2     Partial Exercise. Except as specified in
this Section 5.2, any exercisable portion of the Option or the entire Option, if then wholly exercisable, may be exercised in whole or in part at any time prior to the time when the Option or portion thereof becomes unexercisable under
Section 4.2 hereof. If the vested portion of any Option is less than one hundred (100) shares, it may be exercised with respect to 

  
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all shares for which it is vested. In all other cases, no portion of any Option for less than one hundred (100) shares (as adjusted pursuant to Section 6.2 below) may be exercised.

 5.3     Manner of Exercise. The Option, or any exercisable portion thereof, may be exercised solely by delivery to
the Secretary of the Company (or any third party administrator or other person or entity designated by the Company), during regular business hours, of all of the following prior to the time when the Option or such portion thereof becomes
unexercisable under Section 4.2 hereof: 
  

	 	(a)	An exercise notice in a form specified by the Administrator, stating that the Option or portion thereof is thereby exercised, such notice complying with all applicable
rules established by the Administrator; 

  

	 	(b)	The receipt by the Company of full payment for the shares of Common Stock with respect to which the Option or portion thereof is exercised, including payment of any
applicable withholding tax, which shall be made by deduction from other compensation payable to Optionee or in such other form of consideration permitted under Section 5.4 hereof that is acceptable to the Company; 

 

	 	(c)	Any other written representations as may be required in the Administrator’s reasonable discretion to evidence compliance with the Securities Act of 1933, as
amended (the “Securities Act”), or any other applicable law, rule or regulation; and 

  

	 	(d)	In the event the Option or portion thereof shall be exercised pursuant to Section 5.1 hereof by any person or persons other than Optionee, appropriate proof of the
right of such person or persons to exercise the Option. 

 Notwithstanding any of the foregoing, the Company shall have the right
to specify all conditions of the manner of exercise, which conditions may vary by country and which may be subject to change from time to time. 

5.4     Method of Payment. Payment of the exercise price shall be by any of the following, or a combination thereof, at the
election of Optionee: 
  

	 	(a)	Cash or check; 

  

	 	(b)	With the consent of the Administrator, surrender of shares of Common Stock (including, without limitation, shares of Common Stock otherwise issuable upon exercise of
the Option) held for such period of time as may be required by the Administrator in order to avoid adverse accounting consequences and having a Fair Market Value on the date of delivery equal to the aggregate exercise price of the Option or
exercised portion thereof; or 

  

	 	(c)	Other property acceptable to the Administrator (including, without limitation, through the delivery of a notice that Optionee has placed a market sell order with a
broker with respect to shares of Common Stock then issuable upon exercise of the Option, and that the broker has been directed to pay a sufficient portion of the net proceeds of the sale to the Company in satisfaction of the Option exercise price;
provided that payment of such proceeds is then made to the Company at such time as may be required by the Company, but in any event not later than the settlement of such sale). 

5.5     Tax Withholding. The Optionee shall pay to the Company by one of the permitted payment methods under Section 5.4,
promptly upon exercise of an Option or, if later, the date that the amount of 

  
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such obligations becomes determinable, all applicable federal, state, local and foreign withholding taxes that the Administrator, in its discretion, determines to result upon exercise of an
Option or from a transfer or other disposition of shares of Common Stock acquired upon exercise of an Option or otherwise related to an Option or shares of Common Stock acquired in connection with an Option. 

5.6     Conditions to Issuance of Common Stock. The shares of Common Stock deliverable upon the exercise of the Option, or any
portion thereof, may be either previously authorized but unissued shares of Common Stock or issued shares of Common Stock which have then been reacquired by the Company. Such shares of Common Stock shall be fully paid and nonassessable. The Company
shall not be required to issue or deliver any shares of Common Stock purchased upon the exercise of the Option or portion thereof prior to fulfillment of all of the following conditions: 

 

	 	(a)	The admission of such shares of Common Stock to listing on all stock exchanges on which such Common Stock is then listed; 

 

	 	(b)	The completion of any registration or other qualification of such shares of Common Stock under any state or federal law or under rulings or regulations of the
Securities and Exchange Commission or of any other governmental regulatory body, which the Administrator shall, in its absolute discretion, deem necessary or advisable; 

 

	 	(c)	The obtaining of any approval or other clearance from any state or federal governmental agency which the Administrator shall, in its absolute discretion, determine to
be necessary or advisable; 

  

	 	(d)	The receipt by the Company of full payment for such shares of Common Stock, including payment of any applicable withholding tax, which may be in one or more of the
forms of consideration permitted under Section 5.4 hereof; and 

  

	 	(e)	The lapse of such reasonable period of time following the exercise of the Option as the Administrator may from time to time establish for reasons of administrative
convenience. 

 5.7     Rights as Stockholder. The holder of the Option shall not be, nor have any of
the rights or privileges of, a stockholder of the Company, including, without limitation, voting rights and rights to dividends, in respect of any shares of Common Stock purchasable upon the exercise of any part of the Option unless and until such
shares of Common Stock shall have been issued by the Company and held of record by such holder (as evidenced by the appropriate entry on the books of the Company or of a duly authorized transfer agent of the Company). No adjustment will be made for
a dividend or other right for which the record date is prior to the date the shares of Common Stock are issued, except as provided in Section 6.2. 
 ARTICLE 6 
 OTHER PROVISIONS 

6.1     Change in Control. If the Company undergoes a Change in Control, then any surviving corporation or entity or acquiring
corporation or entity, or affiliate of such corporation or entity, may assume the Option or may substitute similar stock awards (including an award to acquire the same consideration paid to the stockholders in the transaction described in this
Section 6.1) for the Option. In the event any surviving corporation or entity or acquiring corporation or entity in a Change in Control, or affiliate of such corporation or entity, does not assume the Option or does not substitute similar stock
awards for the Option, then (i) if Optionee has not incurred a Termination of Service prior to such event, the vesting of the Option (and, if applicable, the time during which the Option may be exercised) shall be

  
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accelerated and made fully exercisable and all restrictions thereon shall lapse at least ten (10) days prior to the closing of the Change in Control (and the Option terminated if not
exercised prior to the closing of such Change in Control) and (ii) if Optionee has incurred a Termination of Service prior to such event, the Option shall be terminated if not exercised prior to the closing of the Change in Control. 

6.2     Stock Dividend, Reorganization or Liquidation. 

 

	 	(a)	If (i) the Company shall at any time be involved in a transaction described in Section 424(a) of the Code (or any successor provision) or any “corporate
transaction” described in the regulations thereunder; (ii) the Company shall declare a dividend payable in, or shall subdivide or combine, its Common Stock or (iii) any other event with substantially the same effect shall occur, the
Administrator shall, with respect to the Option, proportionately adjust the number of shares of Common Stock subject to the Option, the exercise price per share or both so as to preserve the rights of the Optionee substantially proportionate to the
rights of the Optionee prior to such event. 

  

	 	(b)	If the Company shall at any time declare an extraordinary dividend with respect to its Common Stock, whether payable in cash or other property, the Administrator may,
in the exercise of its sole discretion and with respect to the Option, proportionately adjust the number of shares of Common Stock subject to the Option, the exercise price per share or both so as to preserve the rights of the Optionee substantially
proportionate to the rights of the Optionee prior to such event. 

  

	 	(c)	If the Company is liquidated or dissolved, the Administrator may allow the Optionee to exercise all or any part of the unvested portion of the Option held by the
Optionee, provided the Optionee does so prior to the effective date of such liquidation or dissolution. If the Optionee does not exercise the Option prior to such effective date, the Option shall terminate as of the effective date of the liquidation
or dissolution. 

  

	 	(d)	The foregoing adjustments in the shares subject to the Option shall be made by the Administrator or by the applicable terms of any assumption or substitution document.

  

	 	(e)	The grant of the Option shall not affect in any way the right or power of the Company to make adjustments, reclassifications, reorganizations or changes of its capital
or business structure, to merge, consolidate or dissolve, to liquidate or to sell or transfer all or any part of its business or assets. 

 Optionee acknowledges that the Option is subject to adjustment, modification and termination in certain events as provided in this Agreement and Section 6.2. 

6.3     Interpretation. The Administrator shall have the power to interpret this Agreement and to adopt such rules for the
interpretation and application of the Agreement as are consistent therewith and to interpret, amend or revoke any such rules. All actions taken and all interpretations and determinations made by the Administrator in good faith shall be final and
binding upon Optionee, the Company and all other interested persons. No member of the Administrator shall be personally liable for any action, determination or interpretation made in good faith with respect to this Agreement or the Option.

 6.4     Whole Shares. The Option may only be exercised for whole shares of Common Stock. 

6.5     Option Not Transferable. Subject to Section 5.1 hereof, the Option may not be sold, pledged, assigned or
transferred in any manner other than by will or the laws of descent and distribution, unless and until the shares of Common Stock underlying the Option have been issued, and all restrictions applicable to such shares of Common Stock have lapsed.
Neither the Option nor any interest or right 

  
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therein shall be liable for the debts, contracts or engagements of Optionee or his or her successors in interest or shall be subject to disposition by transfer, alienation, anticipation, pledge,
encumbrance, assignment or any other means whether such disposition be voluntary or involuntary or by operation of law by judgment, levy, attachment, garnishment or any other legal or equitable proceedings (including bankruptcy), and any attempted
disposition thereof shall be null and void and of no effect, except to the extent that such disposition is permitted by the preceding sentence. 

6.6     Binding Agreement. Subject to the limitation on the transferability of the Option contained herein, this Agreement
will be binding upon and inure to the benefit of the heirs, legatees, legal representatives, successors and assigns of the parties hereto. 

6.7     Notices. Any notice to be given under the terms of this Agreement to the Company shall be addressed to the Company in
care of the Secretary of the Company at the Company’s principal office, and any notice to be given to Optionee shall be addressed to Optionee at Optionee’s last address reflected on the Company’s records. By a notice given pursuant to
this Section 6.7, either party may hereafter designate a different address for notices to be given to that party. Any notice which is required to be given to Optionee shall, if Optionee is then deceased, be given to the person entitled to
exercise his or her Option pursuant to Section 5.1 hereof by written notice under this Section 6.7. Any notice shall be deemed duly given when sent via email or when sent by certified mail (return receipt requested) and deposited (with
postage prepaid) in a post office or branch post office regularly maintained by the United States Postal Service. 
 6.8    
Titles. Titles are provided herein for convenience only and are not to serve as a basis for interpretation or construction of this Agreement. 
 6.9     Governing Law. The laws of the State of Delaware shall govern the interpretation, validity, administration, enforcement and performance of the terms of this Agreement
regardless of the law that might be applied under principles of conflicts of laws. 
 6.10     Conformity to Securities
Laws. Optionee acknowledges that this Agreement is intended to conform to the extent necessary with all provisions of the Securities Act and the Exchange Act and any and all regulations and rules promulgated by the Securities and Exchange
Commission thereunder, and state securities laws and regulations. Notwithstanding anything herein to the contrary, the Option is granted and may be exercised, only in such a manner as to conform to such laws, rules and regulations. To the extent
permitted by applicable law, this Agreement shall be deemed amended to the extent necessary to conform to such laws, rules and regulations. 

6.11     Amendments, Suspension and Termination. This Agreement may be wholly or partially amended or otherwise modified,
suspended or terminated at any time or from time to time by the Administrator; provided that, no amendment, modification, suspension or termination of this Agreement shall adversely affect the Option in any material way without the prior
written consent of Optionee. 
 6.12     Successors and Assigns. The Company may assign any of its rights under this
Agreement to single or multiple assignees, and this Agreement shall inure to the benefit of the successors and assigns of the Company. Subject to the restrictions on transfer herein set forth in Section 6.5 hereof, this Agreement shall be
binding upon Optionee and his or her heirs, executors, administrators, successors and assigns. 
 6.13     Limitations
Applicable to Section 16 Persons. Notwithstanding any other provision of this Agreement, if Optionee is an Insider, the Option and this Agreement shall be subject to any additional limitations set forth in any applicable exemptive rule
under Section 16 of the Exchange Act (including any amendment to Rule 16b-3 of the Exchange Act) that are requirements for the application of such 

  
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exemptive rule. To the extent permitted by applicable law, this Agreement shall be deemed amended to the extent necessary to conform to such applicable exemptive rule. 

6.14     Entire Agreement. This Agreement constitutes the entire agreement of the parties and supersede in their entirety all
prior undertakings and agreements of the Company and Optionee with respect to the subject matter hereof. 
 6.15    
Section 409A. This Option is not intended to constitute “nonqualified deferred compensation” within the meaning of Section 409A of the Code (together with any Department of Treasury regulations and other interpretive
guidance issued thereunder, including without limitation any such regulations or other guidance that may be issued after the date hereof, “Section 409A”). However, notwithstanding any other provision of this Agreement, if at
any time the Administrator determines that the Option (or any portion thereof) may be subject to Section 409A, the Administrator shall have the right in its sole discretion (without any obligation to do so or to indemnify Optionee or any other
person for failure to do so) to adopt such amendments to this Agreement, or adopt other policies and procedures (including amendments, policies and procedures with retroactive effect), or take any other actions, as the Administrator determines are
necessary or appropriate either for the Option to be exempt from the application of Section 409A or to comply with the requirements of Section 409A. 
 6.16     Limitation on Optionee’s Rights. The Option confers no rights or interests other than as herein provided. This Agreement creates only a contractual obligation on
the part of the Company as to amounts payable and shall not be construed as creating a trust. Optionee shall have only the rights of a general unsecured creditor of the Company with respect to amounts credited and benefits payable, if any, with
respect to the Option, and rights no greater than the right to receive the Common Stock as a general unsecured creditor with respect to options, as and when exercised pursuant to the terms hereof. 

 

									
	DIADEXUS, INC.:	 		 	OPTIONEE:
					
	 By:
	 	/s/ Pauline Mak	 		 	 By:
	 	/s/ Brian E. Ward
	 Print Name:
	 	Pauline Mak	 		 	 Print Name:
	 	Brian E. Ward
	 Title:
	 	Director of Finance	 		 		 	
	 Address:
	 	349 Oyster Point Blvd.	 		 	 Address:
	 	 
		 	South San Francisco, CA 94080	 		 		 	 

  
 10Change in Control and Severance Agreement

 Exhibit 10.4 
 DIADEXUS, INC. 
 CHANGE IN CONTROL AND SEVERANCE AGREEMENT

 This Change in Control and Severance Agreement (the “Agreement”) is made and entered into by and between
Brian Ward (“Executive”) and diaDexus, Inc. (the “Company”), effective as of the latest date set forth by the signatures of the parties hereto below (the “Effective Date”). 

R E C I T A L S 
 A.         It is expected that the Company from time to time will consider the possibility of an acquisition by another company or other change in control. The
Compensation Committee (the “Compensation Committee”) of the Board of Directors of the Company (the “Board”) recognizes that such consideration as well as the possibility of an involuntary termination can be a
distraction to Executive and can cause Executive to consider alternative employment opportunities. The Compensation Committee has determined that it is in the best interests of the Company and its stockholders to assure that the Company will have
the continued dedication and objectivity of Executive, notwithstanding the possibility, threat or occurrence of such an event. 

B.         The Compensation Committee believes that it is in the best interests of the Company
and its stockholders to provide Executive with an incentive to continue Executive’s employment and to motivate Executive to maximize the value of the Company upon a Change in Control (as defined below) for the benefit of its stockholders.

 C.         The Board believes that it is imperative to provide Executive with
severance benefits upon certain terminations of Executive’s service to the Company that enhance Executive’s financial security and provide incentive and encouragement to Executive to remain with the Company notwithstanding the possibility
of such an event. 
 D.         Certain capitalized terms used in this Agreement are
defined in Section 7 below. 
 The parties hereto agree as follows: 

1.         Term of Agreement. This Agreement shall become effective as of the Effective
Date and terminate upon the date that all obligations of the parties hereto with respect to this Agreement have been satisfied. 

2.         At-Will Employment. The Company and Executive acknowledge that Executive’s
employment is and shall continue to be “at-will,” as defined under applicable law. If Executive’s employment terminates for any reason, Executive shall not be entitled to any payments, benefits, damages, awards or compensation other
than as provided by this Agreement. 

 3.         Termination without Cause Outside of a
Change in Control Period. If, on or after the first anniversary of Executive’s commencement of employment with the Company, the Executive’s employment with the Company is terminated by the Company other than for Cause and such
termination occurs outside of a Change in Control Period, then, subject to Executive executing a general release of all claims against the Company and its affiliates in a form acceptable to the Company (a “Release of Claims”) and
such Release of Claims becoming effective and irrevocable within sixty (60) days following such termination of employment, then in addition to any accrued but unpaid salary, bonus, vacation and expense reimbursement payable in accordance with
applicable law (“Accrued Obligations”), the Company shall provide Executive with the following: 

(a)         Severance. Executive shall be entitled to receive an amount equal to twelve
(12) months of Executive’s base salary at the rate in effect immediately prior to Executive’s termination of employment payable in substantially equal installments in accordance with the Company’s standard payroll policies, less
applicable withholdings, with such payments to commence on the payroll date that immediately follows the date the Release of Claims is effective and irrevocable. 
 (b)         Continued Healthcare. If Executive elects to receive continued healthcare coverage pursuant to the provisions of the Consolidated Omnibus Budget
Reconciliation Act of 1985, as amended (“COBRA”), the Company shall directly pay, or reimburse Executive for, the COBRA premium for Executive and Executive’ s covered dependents through the earlier of (i) the twelve
(12) month anniversary of the date of Executive’s termination of employment and (ii) the date Executive and Executive’s covered dependents, if any, become eligible for healthcare coverage under another employer’s plan(s).
After the Company ceases to pay or reimburse premiums pursuant to the preceding sentence, Executive may, if eligible, elect to continue healthcare coverage at Executive’s expense in accordance with the provisions of COBRA. 

4.         Certain Terminations During a Change in Control Period. If, on or after the
first anniversary of Executive’s commencement of employment with the Company, the Executive’s employment with the Company is terminated by the Company for other than Cause or by Executive for Good Reason and such termination occurs during
a Change in Control Period, then, subject to Executive executing a Release of Claims and such Release of Claims becoming effective and irrevocable within sixty (60) days following such termination of employment, in addition to the Accrued
Obligations, the Company shall provide Executive with the following: 
 (a)        
Severance. Executive shall be entitled to receive an amount equal to twelve (12) months of Executive’s base salary at the rate in effect immediately prior to Executive’s termination of employment payable in substantially equal
installments in accordance with the Company’s standard payroll policies, less applicable withholdings, with such payments to commence on the payroll date that immediately follows the date the Release of Claims is effective and irrevocable.

 (b)         Continued Healthcare. If Executive elects to receive continued
healthcare coverage pursuant to the provisions of COBRA, the Company shall directly pay, or reimburse Executive for, the COBRA premium for Executive and Executive’ s covered dependents through the

  
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earlier of (i) the twelve (12) month anniversary of the date of Executive’s termination of employment and (ii) the date Executive and Executive’s covered dependents, if
any, become eligible for healthcare coverage under another employer’s plan(s). After the Company ceases to pay premiums pursuant to the preceding sentence, Executive may, if eligible, elect to continue healthcare coverage at Executive’s
expense in accordance with the provisions of COBRA. 
 (c)         Equity Awards.
Effective immediately prior to such termination, the Executive’s options to purchase shares of the common stock of the Company shall become vested and exercisable and/or the restrictions applicable to unvested or restricted shares of the common
stock of the Company held by Executive shall lapse, in each case, with respect to that number of shares which would have become vested had Executive remained in continuous service with the Company for an additional twelve months following the date
of Executive’s termination of emplyment. 
 5.         Other Termination. If
Executive’s employment with the Company is terminated by the Company for Cause or by Executive for any or no reason other than Good Reason within a Change in Control Period or if Executive fails to execute a Release of Claims or such Release of
Claims fails to become effective and irrevocable within sixty (60) days following Executive’s termination of employment, then Executive shall not be entitled to any benefits hereunder other than to receive Executive’s Accrued
Obligations and to elect any continued healthcare coverage as may be required under COBRA or similar state law. 

6.         Limitation on Payments. 

(a)         Parachute Payments. Any provision of this Agreement to the contrary
notwithstanding, if any payment or benefit Executive would receive from the Company pursuant to this Agreement or otherwise (“Payment”) would (i) constitute a “parachute payment” within the meaning of
Section 280G of the Code, and (ii) but for this sentence, be subject to the excise tax imposed by Section 4999 of the Code (the “Excise Tax”), then such Payment will be equal to the Reduced Amount (as defined below).
The “Reduced Amount” will be either (1) the largest portion of the Payment that would result in no portion of the Payment (after reduction) being subject to the Excise Tax or (2) the entire Payment, whichever amount after
taking into account all applicable federal, state and local employment taxes, income taxes, and the Excise Tax (all computed at the highest applicable marginal rate, net of the maximum reduction in federal income taxes which could be obtained from a
deduction of such state and local taxes), results in Executive’ s receipt, on an after-tax basis, of the greatest amount of the Payment. If a reduction in the Payment is to be made so that the Payment equals the Reduced Amount, (x) the
Payment will be paid only to the extent permitted under the Reduced Amount alternative, and Executive will have no rights to any additional payments and/or benefits constituting the Payment, and (y) reduction in payments and/or benefits will
occur in the following order: (1) reduction of cash payments; (2) cancellation of accelerated vesting of equity awards other than stock options; (3) cancellation of accelerated vesting of stock options; and (4) reduction of other
benefits paid to Executive. In the event that acceleration of vesting of equity award compensation is to be reduced, such acceleration of vesting will be cancelled in the reverse order of the date of grant of Executive’s equity awards.

  
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 (b)         Accounting Firm. The accounting
firm engaged by the Company for general tax purposes as of the day prior to the Change in Control will perform the calculations set forth in Section 6(a). If the firm so engaged by the Company is serving as accountant or auditor for the
acquiring company, the Company will appoint a nationally recognized accounting firm to make the determinations required hereunder. The Company will bear all expenses with respect to the determinations by such firm required to be made hereunder. The
accounting firm engaged to make the determinations hereunder will provide its calculations, together with detailed supporting documentation, to the Company within fifteen (15) days before the consummation of a Change in Control (if requested at
that time by the Company) or such other time as requested by the Company. If the accounting firm determines that no Excise Tax is payable with respect to a Payment, either before or after the application of the Reduced Amount, it will furnish the
Company with documentation reasonably acceptable to the Company that no Excise Tax will be imposed with respect to such Payment. Any good faith determinations of the accounting firm made hereunder will be final, binding and conclusive upon the
Company and Executive. 
 7.         Definition of Terms. The following terms
referred to in this Agreement shall have the following meanings: 
 (a)        
Cause. “Cause” means (i) Executive’s willful failure to substantially perform Executive’s duties for the Company (other than any such failure resulting from Executive’s total and permanent disability);
(ii) Executive’s willful failure to carry out, or comply with, in any material respect any lawful directive of the Board; (iii) Executive’s commission at any time of any act or omission that results in, or may reasonably be
expected to result in, a conviction, plea of no contest, plea of nolo contendere, or imposition of unadjudicated probation for any felony or crime involving moral turpitude; (iv) Executive’s unlawful use (including being under the
influence) or possession of illegal drugs on the Company’s premises or while performing Executive’s duties and responsibilities for the Company; (v) Executive’s commission at any time of any act of fraud, embezzlement,
misappropriation, misconduct, conversion of assets of the Company, or breach of fiduciary duty against the Company (or any predecessor thereto or successor thereof); or (vi) Executive’s material breach of any agreement with the Company
(including, without limitation, any breach of the restrictive covenants of any such agreement); and which, in the case of clauses (i), (ii) and (vi), continues beyond thirty (30) days after the Company has provided Executive written notice
of such failure or breach (to the extent that, in the reasonable judgment of the Board, such failure or breach can be cured by Executive). Whether or not an event giving rise to “Cause” occurs will be determined by the Board in its sole
discretion. 
 (b)         Change in Control. “Change in
Control” means (i) the acquisition of the Company by another entity, or entities acting as a group, by means of any transaction or series of related transactions (including, without limitation, any reorganization, merger or
consolidation) that results in such entity or entities holding more than fifty percent (50%) of the outstanding voting power of the Company (other than a bona fide equity financing transaction or transfers between affiliated funds) or
(ii) a sale or other disposition by the Company of all or substantially all of the assets of the Company. 

  
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 (c)         Change in Control Period.
“Change in Control Period” means that period of time commencing on the consummation of a Change in Control and ending on the first anniversary of such Change in Control. 

(d)         Good Reason. “Good Reason” means Executive’s resignation
from employment with the Company after the occurrence, without Executive’s written consent, of any of the following on or after a Change in Control: one or more of the following conditions occurs on or following a Change in Control without
Executive’s written consent: (i) a material diminution in Executive’s authority, duties, or responsibilities as in effect as of immediately prior to a Change in Control; (ii) a material reduction in Executive’s Annual Base
Salary as in effect as of immediately prior to a Change in Control (other than a reduction that affects all senior executives of the Company to a similar degree); or (iii) a material change in the geographic location of the principal offices at
which Executive must perform Executive’s services as of immediately prior to a Change in Control (which shall in no event include a relocation of Executive’s principal office of less than sixty (60) miles from South San Francisco,
CA). Notwithstanding the foregoing, in no event shall Executive have Good Reason to terminate Executive’s employment unless Executive provides to the Company written notice of the condition giving rise to Good Reason within sixty (60) days
after the initial occurrence of such condition, such condition continues beyond thirty (30) days after the Company receives such notice (the “Cure Period”) and Executive’s resignation for Good Reason is effective within
thirty (30) days after the end of the Cure Period. 
 8.         Successors.

 (a)         Company’s Successors. Any successor to the Company (whether
direct or indirect and whether by purchase, merger, consolidation, liquidation or otherwise) to all or substantially all of the Company’s business and/or assets shall assume the obligations under this Agreement and agree expressly to perform
the obligations under this Agreement in the same manner and to the same extent as the Company would be required to perform such obligations in the absence of a succession. For all purposes under this Agreement, the term “Company” shall
include any successor to the Company’s business and/or assets. 
 (b)        
Executive’s Successors. The terms of this Agreement and all rights of Executive hereunder shall inure to the benefit of, and be enforceable by, Executive’s personal or legal representatives, executors, administrators, successors,
heirs, distributees, devisees and legatees. 
 9.         Notices. Notices and
all other communications contemplated by this Agreement shall be in writing and shall be deemed to have been duly given when personally delivered or one day following mailing via Federal Express or similar overnight courier service. In the case of
Executive, mailed notices shall be addressed to Executive at Executive’s home address that the Company has on file for Executive. In the case of the Company, mailed notices shall be addressed to its corporate headquarters, and all notices shall
be directed to the attention of its Chief Executive Officer. 

  
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 10.         Restrictive Covenants.

 (a)         Proprietary Information Agreement. Executive shall remain bound by
Executive’s obligations under the Company’s standard Proprietary Information and Inventions Assignment Agreement (the “Proprietary Information Agreement”). 

(b)         Proprietary Information. Without limiting the Proprietary Information
Agreement, except as Executive reasonably and in good faith determines to be required in the faithful performance of Executive’s duties to the Company, Executive shall at all times before and after Executive’s termination of employment
maintain in confidence and shall not directly or indirectly, use, disseminate, disclose or publish, for Executive’s benefit or the benefit of any other person or entity, any confidential or proprietary information or trade secrets of or
relating to the Company, including, without limitation, information with respect to the Company’s operations, processes, protocols, products, inventions, business practices, finances, principals, vendors, suppliers, customers, potential
customers, marketing methods, costs, prices, contractual relationships, regulatory status, compensation paid to employees or other terms of employment (“Proprietary Information”), or deliver to any person or entity, any document,
record, notebook, computer program or similar repository of or containing any such Proprietary Information. Executive’s obligation to maintain and not use, disseminate, disclose or publish, or use for Executive’s benefit or the benefit of
any other person or entity, any Proprietary Information after the date Executive terminates employment will continue so long as such Proprietary Information is not, or has not by legitimate means become, generally known and in the public domain
(other than by means of Executive’s direct or indirect disclosure of such Proprietary Information) and continues to be maintained as Proprietary Information by the Company. The parties hereby stipulate and agree that as between them, the
Proprietary Information identified herein is important, material and affects the successful conduct of the businesses of the Company (and any successor or assignee of the Company). 

(c)         Nonsolicitation. Without limiting the Proprietary Information Agreement,
Executive hereby agrees that Executive shall not while employed or otherwise providing services to the Company and with respect to subsection (ii) below, within the one year period immediately following the termination of Executive’s
employment or other service to the Company, directly or indirectly, either for Executive or on behalf of any other person or entity, (i) recruit or otherwise solicit or induce any employee, customer or supplier of the Company to terminate its
employment or arrangement with the Company, or otherwise change its relationship with the Company, or (ii) hire, or cause to be hired, any person who was employed by the Company at any time during the twelve (12)-month period immediately prior
to the date Executive terminates employment with the Company or who thereafter becomes employed by the Company. 

(d)         Return of Materials. Upon termination of Executive’s employment with the
Company for any reason, Executive will promptly deliver to the Company (i) all correspondence, drawings, manuals, letters, notes, notebooks, reports, programs, plans, proposals, financial documents, or any other documents that are Proprietary
Information, including all physical and digital copies thereof, and (ii) all other Company property (including, without limitation, any 

  
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personal computer or wireless device and related accessories, keys, credit cards and other similar items) which is in Executive’s possession, custody or control. 

(e)         Execption to Restrictive Covenants. Notwithstanding anything in this
Section 10 to the contrary, Executive may respond to a lawful and valid subpoena or other legal process but shall give the Company the earliest possible notice thereof, and shall, as much in advance of the return date as possible, make
available to the Company and its counsel the documents and other information sought, and shall assist such counsel in resisting or otherwise responding to such process. 
 (f)         Nondisparagement. Executive agrees not to disparage the Company, any of its products or practices, or any of its directors, officers, agents,
representatives, partners, members, equity holders or affiliates, either orally or in writing, at any time, provided, that Executive may confer in confidence with Executive’s legal representatives and make truthful statements as required
by law. 
 (g)         Subsequent Employment. Prior to accepting other employment
or any other service relationship prior to the first anniversary of Executive’s termination of employment, Executive shall provide a copy of this Section 10 to any recruiter who assists Executive in obtaining other employment or any other
service relationship and to any employer or other person or entity with which Executive discusses potential employment or any other service relationship. 
 (h)         Enforceability. In the event the terms of this Section 10 shall be determined by any court of competent jurisdiction to be unenforceable by
reason of its extending for too great a period of time or over too great a geographical area or by reason of its being too extensive in any other respect, it will be interpreted to extend only over the maximum period of time for which it may be
enforceable, over the maximum geographical area as to which it may be enforceable, or to the maximum extent in all other respects as to which it may be enforceable, all as determined by such court in such action. Any breach or violation by Executive
of the provisions of this Section 10 shall toll the running of any time periods set forth in this Section 10 for the duration of any such breach or violation. 
 (i)         Affiliates. As used in this Section 6, the term “Company” shall include the Company and any parent, affiliated, related and/or
direct or indirect subsidiary entity thereof. 
 11.         Dispute Resolution.
To ensure the timely and economical resolution of disputes that arise in connection with this Agreement, Executive and the Company agree that any and all controversies, claims and disputes arising out of or relating to this Agreement, including
without limitation any alleged violation of its terms, shall be resolved by final and binding arbitration before a single neutral arbitrator in San Mateo County, California, in accordance with the Employment Dispute Resolution Rules of the American
Arbitration Association (“AAA”). The arbitration shall be commenced by filing a demand for arbitration with the AAA within fourteen (14) days after the filing party has given notice of such breach to the other party. The arbitrator
shall award the prevailing party attorneys’ fees and expert fees, if any. Notwithstanding the foregoing, it is acknowledged that it will be impossible to measure in money the damages that would be suffered if

  
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the parties fail to comply with any of the obligations imposed on them under Section 10 hereof, and that in the event of any such failure, an aggrieved person will be irreparably damaged and
will not have an adequate remedy at law. Any such person shall, therefore, be entitled to injunctive relief, including specific performance, to enforce such obligations, and if any action shall be brought in equity to enforce any of the provisions
of Section 10 of this Agreement, none of the parties hereto shall raise the defense that there is an adequate remedy at law. 
 12.         Miscellaneous Provisions. 
 (a)         Section 409A. 
 (i)         Separation from Service. Notwithstanding any provision to the contrary in this Agreement, no amount deemed deferred compensation subject to
Section 409A of the Code shall be payable pursuant to Sections 3 or 4 unless Executive’s termination of employment constitutes a “separation from service” with the Company within the meaning of Section 409A of the Code and
the Department of Treasury regulations and other guidance promulgated thereunder (a “Separation from Service”) and, except as provided under Section 12(a)(ii) of this Agreement, any such amount shall be paid, or in the case of
installments commencement payment, on the sixtieth (60th) day following Executive’s Separation from Service. 

(ii)         Specified Employee. Notwithstanding any provision to the contrary in this
Agreement, if Executive is deemed at the time of Executive’s Separation from Service to be a “specified employee” for purposes of Section 409A(a)(2)(B)(i) of the Code, to the extent delayed commencement of any portion of the
benefits to which Executive is entitled under this Agreement is required in order to avoid a prohibited distribution under Section 409A(a)(2)(B)(i) of the Code, such portion of Executive’s benefits shall not be provided to Executive until
the earlier of (a) the expiration of the six (6)-month period measured from the date of Executive’s Separation from Service or (b) the date of Executive’s death. Upon the first business day following the expiration of the
applicable Code Section 409A(a)(2)(B)(i) period, all payments deferred pursuant to this Section 12(a)(ii) shall be paid in a lump sum to Executive, and any remaining payments due under this Agreement shall be paid as otherwise provided
herein. 
 (iii)         Expense Reimbursements. To the extent that any
reimbursements payable pursuant to this Agreement are subject to the provisions of Section 409A of the Code, any such reimbursements payable to Executive pursuant to this Agreement shall be paid to Executive no later than December 31 of
the year following the year in which the expense was incurred, the amount of expenses reimbursed in one year shall not affect the amount eligible for reimbursement in any subsequent year, and Executive’s right to reimbursement under this
Agreement will not be subject to liquidation or exchange for another benefit. 

(iv)         Installments. For purposes of Section 409A of the Code,
Executive’s right to receive installment payments pursuant to Sections 3 and 4 shall be treated as a right to receive a series of separate and distinct payments. 

  
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 (b)         Waiver. No provision of this
Agreement shall be modified, waived or discharged unless the modification, waiver or discharge is agreed to in writing and signed by Executive and by an authorized officer of the Company (other than Executive). No waiver by either party of any
breach of, or of compliance with, any condition or provision of this Agreement by the other party shall be considered a waiver of any other condition or provision or of the same condition or provision at another time. 

(c)         Whole Agreement. This Agreement and the Proprietary Information Agreement
represent the entire understanding of the parties hereto with respect to the subject matter hereof and supersede all prior arrangements and understandings regarding same including, without limitation, any severance provisions of any offer letter
agreement or employment agreement between Executive and the Company. 
 (d)        
Choice of Law. The validity, interpretation, construction and performance of this Agreement shall be governed by the laws of the State of California. 
 (e)         Severability. The invalidity or unenforceability of any provision or provisions of this Agreement shall not affect the validity or enforceability
of any other provision hereof, which shall remain in full force and effect. 

(f)         Counterparts. This Agreement may be executed in counterparts, each of which
shall be deemed an original, but all of which together will constitute one and the same instrument. 
 (Signature page
follows) 

  
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 IN WITNESS WHEREOF, each of the parties has executed this Agreement, in the case of the
Company by its duly authorized officer, as of the day and year set forth below. 

			
	DIADEXUS, INC.
		
	By:	 	/s/ Lori Rafield
		 	Lori Rafield
		
	Title:	 	Chairman of the BOD
		
	Date:	 	9/22/11

  

	
	EXECUTIVE
	
	/s/ Brian E. Ward
	Brian Ward
	
	Date:09/21/2011                          
                                  

 Signature Page to Change in Control and Severance Agreement

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