Document:

exv10w21

EXHIBIT 10.21

ANTHERA PHARMACEUTICALS, INC.

NOTE PURCHASE AGREEMENT

DECEMBER 11, 2009

 

 

TABLE OF CONTENTS

	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	Page	 
	1.	 	Definitions	 	 	1	 
	 
	 	 	 	 	 	 	 	 
	2.	 	Amount and Terms of the Initial Notes	 	 	3	 
	 
	 	2.1	 	Issuance of Initial Notes	 	 	3	 
	 
	 	2.2	 	Initial Note Conversion	 	 	3	 
	 
	 	2.3	 	Note Exchange; Issuance of Warrants	 	 	4	 
	 
	 	2.4	 	Grant of Security	 	 	6	 
	 
	 	2.5	 	No Prepayment	 	 	6	 
	 
	 	 	 	 	 	 	 	 
	3.	 	Closing Mechanics	 	 	6	 
	 
	 	3.1	 	Closing	 	 	6	 
	 
	 	 	 	 	 	 	 	 
	4.	 	Representations and Warranties of the Company	 	 	6	 
	 
	 	4.1	 	Organization, Good Standing and Qualification	 	 	6	 
	 
	 	4.2	 	Subsidiaries	 	 	7	 
	 
	 	4.3	 	Capitalization; Voting Rights	 	 	7	 
	 
	 	4.4	 	Authorization; Binding Authority	 	 	8	 
	 
	 	4.5	 	Financial Statements	 	 	9	 
	 
	 	4.6	 	Liabilities	 	 	9	 
	 
	 	4.7	 	Agreements; Action	 	 	9	 
	 
	 	4.8	 	Obligations to Related Parties	 	 	10	 
	 
	 	4.9	 	Intellectual Property	 	 	11	 
	 
	 	4.10	 	Compliance with Other Instruments	 	 	11	 
	 
	 	4.11	 	Indebtedness	 	 	12	 
	 
	 	4.12	 	Litigation	 	 	12	 
	 
	 	4.13	 	Employees	 	 	13	 
	 
	 	4.14	 	Registration Rights and Voting Rights	 	 	13	 
	 
	 	4.15	 	Compliance with Laws; Permits	 	 	13	 
	 
	 	4.16	 	Environmental and Safety Laws	 	 	14	 
	 
	 	4.17	 	Material Changes	 	 	15	 
	 
	 	4.18	 	Offering Valid	 	 	15	 
	 
	 	4.19	 	Title to Properties and Assets; Liens, Etc	 	 	16	 
	 
	 	4.20	 	Tax	 	 	16	 
	 
	 	4.21	 	Investment Company Act	 	 	16	 
	 
	 	4.22	 	Internal Controls and Disclosures	 	 	16	 
	 
	 	4.23	 	Money Laundering Laws	 	 	17	 
	 
	 	4.24	 	OFAC	 	 	17	 
	 
	 	4.25	 	Insurance	 	 	17	 
	 
	 	4.26	 	Foreign Corrupt Practices Act	 	 	17	 
	 
	 	4.27	 	No Integration	 	 	17	 
	 
	 	4.28	 	Full Disclosure	 	 	18	 

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	 	 	 	 	 	 	Page	 
	5.	 	Representations and Warranties of the Purchasers	 	 	18	 
	 
	 	5.1	 	Requisite Power and Authority	 	 	18	 
	 
	 	5.2	 	Investment Representations	 	 	18	 
	 
	 	5.3	 	Further Limitations on Disposition	 	 	19	 
	 
	 	5.4	 	Legends	 	 	19	 
	 
	 	 	 	 	 	 	 	 
	6.	 	State Commissioners of Corporations	 	 	20	 
	 
	 	6.1	 	California Corporate Securities Law	 	 	20	 
	 
	 	 	 	 	 	 	 	 
	7.	 	Defaults and Remedies	 	 	20	 
	 
	 	7.1	 	Events of Default	 	 	20	 
	 
	 	7.2	 	Remedies	 	 	21	 
	 
	 	 	 	 	 	 	 	 
	8.	 	Covenants of the Company	 	 	21	 
	 
	 	8.1	 	Indebtedness	 	 	21	 
	 
	 	8.2	 	Use of Proceeds	 	 	21	 
	 
	 	 	 	 	 	 	 	 
	9.	 	Conditions to Closing	 	 	21	 
	 
	 	9.1	 	Conditions to Purchasers’ Obligations at the Closing	 	 	21	 
	 
	 	9.2	 	Conditions to Obligations of the Company at the Closing	 	 	23	 
	 
	 	 	 	 	 	 	 	 
	10.	 	Miscellaneous	 	 	23	 
	 
	 	10.1	 	Successors and Assigns	 	 	23	 
	 
	 	10.2	 	Governing Law	 	 	23	 
	 
	 	10.3	 	Facsimile; Counterparts	 	 	23	 
	 
	 	10.4	 	Titles and Subtitles	 	 	23	 
	 
	 	10.5	 	Notices	 	 	23	 
	 
	 	10.6	 	Finder’s Fee	 	 	24	 
	 
	 	10.7	 	Expenses	 	 	24	 
	 
	 	10.8	 	Entire Agreement; Amendments and Waivers	 	 	24	 
	 
	 	10.9	 	Effect of Amendment or Waiver	 	 	24	 
	 
	 	10.10	 	Severability	 	 	24	 
	 
	 	10.11	 	Stock Purchase Agreement	 	 	25	 
	 
	 	10.1	 	Registrable Securities	 	 	25	 
	 
	 	10.2	 	Exculpation Among Purchasers	 	 	25	 
	 
	 	10.3	 	Acknowledgement	 	 	25	 
	 
	 	10.4	 	Further Assurance	 	 	25	 
	 
	 	10.5	 	Waiver of Jury Trial	 	 	25	 
	 
	 	10.6	 	Dispute Resolution	 	 	26	 

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NOTE PURCHASE AGREEMENT

     THIS NOTE PURCHASE AGREEMENT (“Agreement”) is made as of December 11, 2009, by and
among ANTHERA PHARMACEUTICALS, INC., a Delaware corporation (the “Company”), and the
persons and entities (each individually a “Purchaser,” and collectively the
“Purchasers”) named on the Schedule of Purchasers attached hereto (the “Schedule of
Purchasers”). Capitalized terms not otherwise defined in this Agreement shall have the
meanings ascribed to them in Section 1 below.

     THE PARTIES HEREBY AGREE AS FOLLOWS:

     1. Definitions.

          (a) “Common Stock” shall mean the common stock of the Company, par value $0.001 per
share.

          (b) “Consideration” shall mean the amount of money paid by each Purchaser pursuant to
this Agreement as shown on the Schedule of Purchasers.

          (c) “Conversion Shares” shall mean (i) with respect to the Initial Notes, shares of
Common Stock issuable upon conversion of the Initial Notes, and (ii) with respect to the Exchange
Notes, if the Exchange Notes are converted to equity pursuant to Section 2.3(b) below, the Equity
Securities issued in the Next Equity Financing.

          (d) “Corporate Transaction” shall mean (i) the consummation of an Acquisition, as such
is defined in the Company’s Fourth Amended and Restated Certificate of Incorporation of the Company
in the form attached hereto as Exhibit A (as amended from time to time, the “Restated
Certificate”), (ii) the closing of an Asset Transfer, as such is defined in the Restated
Certificate or (iii) the occurrence of a Liquidation Event, as such is defined in the Restated
Certificate.

          (e) “Equity Securities” shall mean the Company’s Common Stock or Preferred Stock or
any securities conferring the right to purchase the Company’s Common Stock or Preferred Stock or
securities convertible into, or exchangeable for (with or without additional consideration), the
Company’s Common Stock or Preferred Stock, except any security granted, issued and/or sold by the
Company to any director, officer, employee or consultant of the Company in such capacity for the
primary purpose of soliciting or retaining their services.

          (f) “Exchange Date” shall mean February 28, 2010.

          (g) “Exchange Notes” shall mean the one or more senior secured convertible promissory
notes issued to each Purchaser pursuant to Section 2.3(a) below, substantially in the form attached
hereto as Exhibit C.

          (h) “Exchange Note Conversion Price” shall mean with respect to a conversion of the
Exchange Notes pursuant to Section 2.3(b) below, the product of (i) the price

 

 

paid per share for Equity Securities by the investors in the Next Equity Financing and (ii)
seventy-five percent (75%).

          (i) “Initial Notes” shall mean the one or more senior secured convertible promissory
notes issued to each Purchaser pursuant to Section 2.1 below, substantially in the form attached
hereto as Exhibit B.

          (j) “Initial Note Conversion Price” shall mean the price per share at which shares of
Common Stock are sold to the public in the IPO minus any per-share underwriting discounts,
commissions or fees.

          (k) “IPO” shall mean the closing of a firmly underwritten public offering pursuant to
an effective registration statement under the Securities Act of 1933, as amended (the
“Securities Act”), covering the offer and sale of Common Stock for the account of the
Company in which the aggregate net proceeds to the Company (after underwriting discounts,
commissions and fees) are at least $50,000,000.

          (l) “July 2009 Purchase Agreement” shall mean that certain Note and Warrant Purchase
Agreement, dated as of July 17, 2009, by and among the Company and the Purchasers party thereto, as
the same may be amended from time to time.

          (m) “Maturity Date” shall mean July 17, 2010.

          (n) “Next Equity Financing” shall mean the next sale (or series of related sales) by
the Company of its Equity Securities following the Exchange Date from which the Company receives
gross proceeds of not less than $10,000,000 (excluding the aggregate amount of debt securities
converted into Equity Securities upon conversion of the Exchange Notes pursuant to Section 2.3(b)
below);

          (o) “Notes” shall mean the Initial Notes and the Exchange Notes.

          (p) “Required Note Holders” shall mean the holders of a majority in interest of the
aggregate principal amount of Notes then outstanding.

          (q) “Rights Agreement” shall mean the Company’s Second Amended and Restated Investors’
Rights Agreement dated July 17, 2009, as may be further amended from time to time.

          (r) “Securities” shall mean the Notes, the Warrants and the Equity Securities issuable
upon conversion of the Notes and/or exercise of the Warrants (including, with and as part of such
Equity Securities, the shares of Common Stock into which such Equity Securities are convertible).

          (s) “Series B-2 Preferred” shall mean the Series B-2 Preferred Stock of the Company,
par value $0.001 per share.

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          (t) “Series B-2 Price” shall mean the Original Issue Price of the Series B-2 Preferred
as such is set forth in the Restated Certificate and as such may be adjusted for any subdivision or
combination of the Company’s capital stock occurring after the Closing Date.

          (u) “Warrants” shall mean one or more warrants issued pursuant to Section 2.3(i)
below.

          (v) “Warrant Coverage Amount” shall mean, with respect to any particular Warrant
issued to a Purchaser, twenty-five percent (25%) of the principal amount of the Exchange Note
issued to such Purchaser in conjunction with such Warrant, provided, however, if,
before April 1, 2010, such Exchange Note has not converted pursuant to Section 2.3(b) or (c) below,
then the Warrant Coverage Amount shall be fifty percent (50%) of the principal amount of such
Exchange Note issued to such Purchaser in conjunction with such Warrant.

          (w) “Warrant Price” shall mean the price paid per share for Equity Securities by the
investors in the Next Equity Financing.

     2. Amount and Terms of the Initial Notes.

          2.1 Issuance of Initial Notes. In return for the Consideration paid by each Purchaser,
the Company shall sell and issue to such Purchaser one or more Initial Notes. Each Initial Note
shall have a principal balance equal to that Consideration paid by such Purchaser for the Initial
Note, as set forth in the Schedule of Purchasers. Each Initial Note shall be convertible pursuant
to Section 2.2 below into Conversion Shares and shall be secured by the assets of the Company as
described in Section 2.4 below. Interest on the Initial Notes shall accrue as described in the
Initial Notes.

          2.2 Initial Note Conversion.

               (a) Initial Public Offering. The principal and unpaid accrued interest of each
Initial Note shall be automatically converted into Conversion Shares upon the closing of the IPO.
The number of Conversion Shares to be issued upon such conversion shall be equal to the quotient
obtained by dividing the outstanding principal and unpaid accrued interest on an Initial Note to be
converted, or portion thereof, on the date of conversion, by the Initial Note Conversion Price.

               (b) No Fractional Shares. Upon the conversion of an Initial Note into Conversion
Shares, in lieu of any fractional shares to which the holder of the Initial Note would otherwise be
entitled, the Company shall pay the Initial Note holder cash equal to such fraction multiplied by
the Initial Note Conversion Price.

               (c) Mechanics of Conversion. The Company shall not be required to issue or deliver
the Conversion Shares until the Initial Note holder has surrendered the Initial Note to the
Company. Such conversion may be made contingent upon the closing of the IPO, provided,
such conversion shall be deemed to occur immediately prior to the closing of the IPO.

               (d) Reservation of Shares. If, at the time of conversion, there are insufficient
authorized Conversion Shares to permit conversion of the Initial Notes in full, the

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Company shall take all corporate action and shall use best efforts to cause the board of
directors of the Company (the “Board”) and the Company’s stockholders to recommend and
approve such actions as are necessary to authorize a sufficient number of shares of Conversion
Shares to permit such conversion in full, and each Purchaser agrees to cooperate with the Company
and to vote any of its voting securities of the Company in favor of any action requiring
stockholder consent to authorize or issue such Conversion Shares to permit such conversion in full.

          2.3 Note Exchange; Issuance of Warrants.

               (a) Note Exchange. In the event that the IPO has not been consummated on or before
the Exchange Date, upon surrender of the Initial Note to the Company, each of the Initial Notes
shall be exchanged for an Exchange Note in substantially the form attached hereto as Exhibit
C. Each Exchange Note shall have a principal balance equal to the Consideration paid by such
Purchaser for the Initial Note originally issued to such Purchaser, as set forth in the Schedule of
Purchasers, and shall reflect interest accrued through the Exchange Date carried forward from such
Initial Note. Each Exchange Note shall be convertible pursuant to Sections 2.3(b) and 2.3(c) below
and shall be secured by the assets of the Company as described in Section 2.4 below. Interest on
the Exchange Notes shall accrue from and after the Exchange Date as described in the Exchange
Notes.

               (b) Conversion of Exchange Notes Upon Next Equity Financing. The principal and unpaid
accrued interest of each Exchange Note shall be automatically converted into Conversion Shares upon
the closing of the Next Equity Financing. The number of Conversion Shares to be issued upon such
conversion shall be equal to the quotient obtained by dividing the outstanding principal and unpaid
accrued interest on an Exchange Note to be converted, or portion thereof, on the date of
conversion, by the Exchange Note Conversion Price. At least five (5) days prior to the closing of
the Next Equity Financing, the Company shall notify the holder of each Exchange Note in writing of
the terms under which the Equity Securities of the Company will be sold in such financing. The
issuance of Conversion Shares pursuant to the conversion of each Exchange Note shall be upon and
subject to the same terms and conditions applicable to the Equity Securities sold in the Next
Equity Financing. For the avoidance of doubt, for example, if the Next Equity Financing is the
sale of Equity Securities including both preferred stock and warrants exercisable for Equity
Securities, the Conversion Shares shall include both preferred stock and warrants exercisable for
Equity Securities.

               (c) Conversion of Exchange Note at the Election of Purchaser. By providing written
notice to the Company, each Purchaser may elect, in the event that a Corporate Transaction occurs
prior to the Next Equity Financing, that the principal and unpaid accrued interest of each Exchange
Note held by such Purchaser shall be converted into shares of Series B-2 Preferred immediately
prior to the closing of such Corporate Transaction. The number of shares of Series B-2 Preferred
to be issued upon such conversion shall be equal to the quotient obtained by dividing the
outstanding principal and unpaid accrued interest on an Exchange Note to be converted, or portion
thereof, on the date of conversion, by the Series B-2 Price.

               (d) No Fractional Shares. Upon the conversion of an Exchange Note into Conversion
Shares or shares of Series B-2 Preferred, in lieu of any fractional shares to which the holder of
the Exchange Note would otherwise be entitled, the Company shall pay the

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Exchange Note holder cash equal to such fraction multiplied by the Exchange Note Conversion
Price or the Series B-2 Price (whichever is then applicable).

               (e) Mechanics of Conversion. The Company shall not be required to issue or deliver
the Conversion Shares or shares of Series B-2 Preferred until the Exchange Note holder has
surrendered the Exchange Note to the Company. Such conversion may be made contingent upon the
closing of the Next Equity Financing or Corporate Transaction, provided, such conversion
shall be deemed to occur immediately prior to the closing of such Next Equity Financing or
Corporate Transaction.

               (f) Reservation of Shares. If, at the time of conversion, there are insufficient
authorized Exchange Note Conversion Shares or shares of Series B-2 Preferred (whichever is then
applicable) to permit conversion of the Exchange Notes or issuance of shares of Series B-2
Preferred upon exercise of the Warrants (as defined below) in full, the Company shall take all
corporate action and shall use best efforts to cause the Board and the Company’s stockholders to
recommend and approve such actions as are necessary to authorize a sufficient number of shares of
Exchange Note Conversion Shares or Series B-2 Preferred to permit such conversion or exercise in
full, and each Purchaser agrees to cooperate with the Company and to vote any of its voting
securities of the Company in favor of any action requiring stockholder consent to authorize or
issue such Exchange Note Conversion Shares or shares of Series B-2 Preferred to permit such
conversion or exercise in full.

               (g) Termination of Conversion Rights. The conversion rights set forth in this Section
2.3 shall be exercisable from and after the date of issuance of the Exchange Notes, and shall
terminate and expire to the extent not previously exercised, on the earliest of (i) the date upon
which all Exchange Notes are fully paid and no longer outstanding, (ii) the closing date of the
IPO, or (iii) upon the consummation by the Company of any Corporate Transaction (each of (ii) and
(iii), a “Terminating Significant Transaction”). The Company shall provide each Purchaser
with at least ten (10) days’ prior written notice of any Terminating Significant Transaction.

               (h) Corporate Transaction Repayment. In the event that the Company consummates a
Corporate Transaction prior to the Next Equity Financing and any Exchange Note has not been
converted pursuant to this Section 2.3, then immediately prior to or simultaneous with the
consummation of such Corporate Transaction, the Company shall pay to the Purchaser holding such
Exchange Note an amount equal to the sum of (i) the outstanding interest accrued on such Exchange
Note and (ii) two (2) times the outstanding principal amount of such Exchange Note.

               (i) Warrants. In the event that the IPO has not been consummated on or before the
Exchange Date, upon surrender of the Initial Note to the Company, each Purchaser shall receive a
warrant to purchase Exchange Note Conversion Shares or shares of Series B-2 Preferred in the form
attached hereto as Exhibit D (the “Warrant”). Each Warrant shall be exercisable
for that number of Exchange Note Conversion Shares determined by dividing the Warrant Coverage
Amount by the Warrant Price, provided, however, if the Exchange Note issued to a
Purchaser in conjunction with such Warrant is converted into shares of Series B-2 Preferred
pursuant to Section 2.3(c) hereof, such Warrant shall instead be exercisable for that

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number of shares of Series B-2 Preferred determined by dividing the Warrant Coverage Amount by
the Series B-2 Price (thereby becoming a “Series B-2 Warrant”). The exercise price for the
Exchange Note Conversion Shares purchasable upon exercise of the Warrants shall be the Warrant
Price applicable to such shares, and the exercise price for the shares of Series B-2 Preferred
purchasable upon exercise of the Series B-2 Warrants shall be the Series B-2 Price.

          2.4 Grant of Security. As collateral security for the prompt and complete payment and
performance when due (whether at the stated maturity, by acceleration or otherwise) of the
obligations evidenced by the Notes, the Company hereby grants to the Purchasers a first priority
security interest in all of the assets of the Company (the “Collateral”). The Company
hereby irrevocably appoints each Purchaser as attorney-in-fact, with full authority in the place
and stead of the Company and in the name of the Company or otherwise, from time to time in any such
Purchaser’s discretion, upon the Company’s failure or inability to do so, to take any action and to
execute any instrument which the Purchaser may deem necessary or advisable to accomplish the
purposes of the security interest granted hereunder, including to file, in its sole discretion, one
or more financing or continuation statements and amendments thereto, relative to any of the
Collateral without the signature of the Company where permitted by law. Each Purchaser shall pay
all costs and expenses that it incurs with respect to the accomplishment and perfection of the
security interest granted hereunder.

          2.5 No Prepayment. The Company may not prepay any principal amount or interest on the
Notes, in whole or in part.

     3. Closing Mechanics.

          3.1 Closing. The closing of the purchase of the Initial Notes in return for the
Consideration paid by each Purchaser (the “Closing”) shall take place at 1:00 pm on the
date hereof (the “Closing Date”), at the offices the Company, or at such other time and
place as the Company and Required Note Holders agree upon orally or in writing. At the Closing,
each Purchaser shall deliver the Consideration to the Company and the Company shall deliver to each
Purchaser one or more executed Initial Notes in return for the respective Consideration provided to
the Company.

     4. Representations and Warranties of the Company. Except as set forth on a Schedule of
Exceptions, the Company hereby represents and warrants to each Purchaser as of the date of this
Agreement as set forth below.

          4.1 Organization, Good Standing and Qualification. The Company is a corporation duly
organized, validly existing and in good standing under the laws of the State of Delaware. The
Company has all requisite corporate power and authority to own and operate its properties and
assets, to execute and deliver this Agreement, to issue and sell the Securities, and to carry out
the provisions of this Agreement, provided, however, that the Company has not
obtained the necessary corporate approval for the authorization of the Equity Securities to be
sold at the closing of the Next Equity Financing. TRX Services Limited (the “Subsidiary”)
has been duly organized and is validly existing as a corporation in good standing under the laws of
the United Kingdom, with corporate power and authority to own or lease its properties and conduct
its business. The Company and the Subsidiary are duly qualified to do business and are in good

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standing as foreign corporations in all jurisdictions in which the nature of their activities
and of their properties (both owned and leased) makes such qualification necessary, except for such
jurisdictions where the failure to so qualify would not (i) have a material adverse effect on the
earnings, business, management, properties, assets, rights, operations, condition (financial or
otherwise) or prospects of the Company and of the Subsidiary taken as a whole or (ii) prevent the
consummation of the transactions contemplated hereby (the occurrence of any such effect or any such
prevention described in the foregoing clauses (i) and (ii) being referred to as a “Material
Adverse Effect”).

          4.2 Subsidiaries. Other than the Subsidiary, the Company does not own or control any
equity security or other interest of any other corporation, limited partnership or other business
entity. The Company is not a participant in any joint venture, partnership or similar arrangement.
Since its inception, the Company has not consolidated or merged with, acquired all or
substantially all of the assets of, or acquired the stock of or any interest in any corporation,
partnership, association, or other business entity.

          4.3 Capitalization; Voting Rights.

               (a) The authorized capital stock of the Company, immediately prior to the Closing, consists of
(i) thirty-one million five hundred seventy-five thousand (31,575,000) shares of Common Stock, par
value $0.001 per share, two million eight hundred thousand two hundred twenty-one (2,800,221) of
which are issued and outstanding, (ii) twenty million four hundred fifty-five thousand nine hundred
thirty-nine (20,455,939) shares of Preferred Stock, par value $0.001 per share, of which (A) nine
hundred forty-five thousand nine hundred thirty-nine (945,939) shares have been designated Series
A-1 Preferred Stock, par value $0.001 per share, nine hundred forty-five thousand nine hundred
thirty-nine (945,939) of which are issued and outstanding, (B) two million eight hundred thousand
(2,800,000) shares have been designated Series A-2 Preferred Stock, par value $0.001 per share, two
million seven hundred seventy-four thousand five hundred ninety-four (2,774,594) of which are
issued and outstanding, (C) four million seven hundred ten thousand (4,710,000) shares have been
designated Series B-1 Preferred Stock, par value $0.001 per share, four million seven hundred two
thousand six hundred forty (4,702,640) of which are issued and outstanding and (D) twelve million
(12,000,000) shares have been designated Series B-2 Preferred Stock, par value $0.001 per share,
five million five hundred twenty-three thousand three hundred thirty-seven (5,523,337) of which are
issued and outstanding. The Series A-1 Preferred Stock, Series A-2 Preferred Stock, Series B-1
Preferred Stock and the Series B-2 Preferred Stock are referred to collectively as the “Preferred
Stock.” A detailed schedule of the Company’s holders of Common Stock and Preferred Stock is set
forth in Schedule 4.3(a) of the Schedule of Exceptions.

               (b) Under the Company’s 2005 Equity Incentive Plan (the “Plan”), (i) one million four
hundred twenty-five thousand two hundred twenty-one (1,425,221) shares have been issued pursuant to
restricted stock purchase agreements and/or the exercise of outstanding options, (ii) options to
purchase two million two hundred sixty-six thousand three hundred fifty-one (2,266,351) shares are
currently outstanding, and (iii) thirty-three thousand four hundred twenty-eight (33,428) shares of
Common Stock remain available under the Plan for future issuance to officers, directors, employees
and consultants of the Company. A detailed schedule

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of the Company’s optionholders holding options issued under the Plan is set forth in Schedule
4.3(b) of the Schedule of Exceptions.

               (c) Other than the shares reserved for issuance under the Plan and except as may be granted
pursuant to this Agreement, there are no outstanding options, warrants, rights (including
conversion or preemptive rights and rights of first refusal), proxy or stockholder agreements, or
agreements of any kind for the purchase or acquisition from the Company of any of its securities.
A detailed schedule of the Company’s optionholders (except as described in Schedule 4.3(b)) or
warrantholders is set forth in Schedule 4.3(c) of the Schedule of Exceptions.

               (d) All issued and outstanding shares of the Company’s Common Stock (i) have been duly
authorized and validly issued and are fully paid and nonassessable, (ii) were issued in compliance
with all applicable state and federal laws concerning the issuance of securities; and (iii) are
subject to a right of first refusal in favor of the Company upon transfer.

               (e) All options granted and Common Stock issued vest as follows: twenty-five percent (25%) of
the shares vest one (1) year following the vesting commencement date, with the remaining
seventy-five percent (75%) vesting in equal monthly installments over the next three (3) years. No
stock plan, stock purchase, stock option or other agreement or understanding between the Company
and any holder of any equity securities or rights to purchase equity securities provides for
acceleration or other changes in the vesting provisions or other terms of such agreement or
understanding as the result of (i) termination of employment or consulting services (whether actual
or constructive); (ii) any merger, consolidated sale of stock or assets, change in control or any
other transaction(s) by the Company; or (iii) the occurrence of any other event or combination of
events.

               (f) The rights, preferences, privileges and restrictions of the shares of the Preferred Stock
are as stated in the Restated Certificate. Each outstanding share of Preferred Stock is
convertible into Common Stock on a one-for-one basis as of the date hereof. A sufficient number of
shares of Series B-2 Preferred has been duly and validly reserved for issuance pursuant to Section
2.3(c) and Section 2.3(i) hereof. When issued against payment therefor in accordance with this
Agreement and the Notes, the Conversion Shares will be validly issued, fully paid and
nonassessable, and will be free of any liens or encumbrances; provided that the Conversion
Shares shall be subject to restrictions on transfer under state and/or federal securities laws as
set forth herein or as otherwise required by such laws at the time a transfer is proposed.

               (g) All outstanding shares of Common Stock and Preferred Stock, and all shares of Common Stock
and Preferred Stock issuable upon the exercise or conversion of outstanding options, warrants or
other exercisable or convertible securities are subject to a market standoff or “lockup” agreement
of not less than 180 days following the Company’s initial public offering.

          4.4 Authorization; Binding Authority. Except for the authorization and issuance of the
Equity Securities issuable in connection with the Next Equity Financing, all corporate action on
the part of the Company, its officers, directors and stockholders necessary for

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the authorization
of this Agreement, the performance of all obligations of the Company hereunder at the Closing, and
the authorization, sale, issuance and delivery of the Securities pursuant hereto has been taken.
This Agreement, the Notes and the Warrants, when executed and delivered in accordance with the
terms of this Agreement, will be valid and binding obligations of the Company enforceable in
accordance with their terms, except (a) as limited by applicable bankruptcy, insolvency,
reorganization, moratorium or other laws of general application affecting enforcement of creditors’
rights and (b) general principles of equity that restrict the availability of equitable remedies.
The sale of the Notes and the subsequent conversion of the Notes into Conversion Shares or shares
of Series B-2 Preferred (and the Common Stock into which such securities are convertible), and the
issuance of the Warrants and the subsequent exercise of the Warrants into Conversion Shares or
shares of Series B-2 Preferred (and the Common Stock into which such securities are convertible)
are not subject to any preemptive rights or rights of first refusal that have not been properly
waived or complied with.

          4.5 Financial Statements. The Company has delivered to the Purchasers the consolidated
financial statements of the Company and the Subsidiary, together with related notes and schedules
for the year ended December 31, 2008 and for the nine months ended September 30, 2009 (the
“Financial Statements”), which present fairly the financial position and the results of
operations and cash flows of the Company and the consolidated Subsidiary, at the indicated dates
and for the indicated periods. Such Financial Statements have been prepared in accordance with
generally accepted principles of accounting (“GAAP”), consistently applied throughout the
periods involved, except as disclosed therein, and all adjustments necessary for a fair
presentation of results for such periods have been made. Except as disclosed on the Schedule of
Exceptions, the Company and the Subsidiary do not have any material liabilities or obligations,
direct or contingent (including any off-balance sheet obligations or any “variable interest
entities” within the meaning of Financial Accounting Standards Board Interpretation No. 46R).
Except as disclosed in the Schedule of Exceptions, neither the Company nor the Subsidiary is aware
of (a) any material weakness in its internal control over financial reporting or (b) change in
internal control over financial reporting that has materially affected, or is reasonably likely to
materially affect, the Company’s internal control over financial reporting.

          4.6 Liabilities. The Company has no material liabilities and, to the best of its knowledge,
has no material contingent liabilities, except current liabilities incurred in the ordinary course
of business which have not been, either in any individual case or in the aggregate, materially
adverse.

          4.7 Agreements; Action.

               (a) Except for agreements explicitly contemplated hereby and agreements between the Company
and its employees with respect to the sale of the Company’s Preferred Stock, there are no
agreements, understandings or proposed transactions between the Company and any of its officers,
directors, employees, affiliates or any affiliate thereof.

               (b) There are no agreements, understandings, instruments, contracts, proposed transactions,
judgments, orders, writs or decrees to which the Company is a party or to its knowledge by which it
is bound which may involve (i) future obligations (contingent or

9

 

otherwise) of, or payments to, the
Company in excess of $50,000, or (ii) the transfer or license of any patent, copyright, trade
secret or other proprietary right to or from the Company (other than licenses by the Company of
“off the shelf” or other standard products), or (iii) provisions restricting the development,
manufacture or distribution of the Company’s products or services, or (iv) indemnification by the
Company with respect to infringements of proprietary rights (other than indemnification obligations
arising from purchase, sale or license agreements entered into in the ordinary course of business).

               (c) The Company has not (i) declared or paid any dividends, or authorized or made any
distribution upon or with respect to any class or series of its capital stock, (ii) incurred or
guaranteed any indebtedness for money borrowed or any other liabilities (other than with respect to
dividend obligations, distributions, indebtedness and other obligations incurred in the ordinary
course of business) individually in excess of $50,000 or, in the case of indebtedness and/or
liabilities individually less than $50,000, in excess of $250,000 in the aggregate, (iii) made any
loans or advances to any person, other than ordinary advances for travel expenses, or (iv) sold,
exchanged or otherwise disposed of any of its assets or rights, other than the sale of its
inventory in the ordinary course of business.

               (d) For the purposes of subsections (b) and (c) above, all indebtedness, liabilities,
agreements, understandings, instruments, contracts and proposed transactions involving the same
person or entity (including persons or entities the Company has reason to believe are affiliated
therewith) shall be aggregated for the purpose of meeting the individual minimum dollar amounts of
such subsections.

               (e) Other than as disclosed in Section 4.7 of the Schedule of Exceptions, the Company has not
engaged in the past three (3) months in any discussion (i) with any representative of any other
business or businesses regarding the consolidation or merger of the Company with or into any such
other business or businesses, (ii) with any corporation, partnership, limited liability company, or
other business entity or any individual regarding the sale, conveyance or disposition of all or
substantially all of the assets of the Company, or a transaction or series of related transactions
in which more than fifty percent (50%) of the voting power of the Company is disposed of, or
(iii) regarding any other form of acquisition, liquidation, dissolution or winding up, of the
Company.

          4.8 Obligations to Related Parties. There are no obligations of the Company to officers,
directors, stockholders, or employees of the Company other than (a) for payment of salary for
services rendered, (b) reimbursement for reasonable expenses incurred on behalf of the Company and
(c) for other standard employee benefits made generally available to all employees (including stock
option agreements outstanding under any stock option plan approved by the Board). No officer,
director or stockholder, or any member of their immediate families, is, directly or indirectly,
interested in any material contract with the Company (other than such
contracts as relate to any such person’s ownership of capital stock or other securities of the
Company).

10

 

          4.9 Intellectual Property.

               (a) The Company owns or possesses sufficient legal rights to all patents, trademarks, service
marks, trade names, copyrights, trade secrets, licenses, information and other proprietary rights
and processes necessary for its business as now conducted and as presently proposed to be
conducted, without any known infringement of the rights of others. There are no outstanding
options, licenses or agreements of any kind relating to the foregoing proprietary rights, nor is
the Company bound by or a party to any options, licenses or agreements of any kind with respect to
the patents, trademarks, service marks, trade names, copyrights, trade secrets, licenses,
information and other proprietary rights and processes of any other person or entity other than
such licenses or agreements arising from the purchase of “off the shelf” or standard products.

               (b) The Company has not received any communications alleging that the Company has violated or,
by conducting its business as presently proposed, would violate any of the patents, trademarks,
service marks, trade names, copyrights or trade secrets or other proprietary rights of any other
person or entity.

               (c) The Company is not aware that any of its employees is obligated under any contract
(including licenses, covenants or commitments of any nature) or other agreement, or subject to any
judgment, decree or order of any court or administrative agency, that would interfere with their
duties to the Company or that would conflict with the Company’s business as proposed to be
conducted. Each employee, officer and consultant of the Company has executed a proprietary
information and inventions agreement in substantially the form previously provided to Purchasers.
No employee, officer or consultant of the Company has excluded works or inventions made prior to
his or her employment with the Company from his or her assignment of inventions pursuant to such
employee, officer or consultant’s proprietary information and inventions agreement. The Company
does not believe it is or will be necessary to utilize any inventions, trade secrets or proprietary
information of any of its employees made prior to their employment with the Company, except for
inventions, trade secrets or proprietary information that have been assigned to the Company and
which are disclosed in the Schedule of Exceptions.

               (d) The Company is not aware of any prior art that would invalidate any of the issued patent
claims. The Company is also not aware of any prior art that would invalidate claims in the pending
patent applications directed to 1) the pharmaceutical composition comprising one or more statins
and one or more sPLA2 inhibitors; or 2) methods of treating dyslipidemia, methods of decreasing
cholesterol levels, LDL levels, or triglyceride levels using one or more sPLA2 inhibitors.
Further, the Company is not aware of any prior art by a party other than Eli Lilly and Company
(“Lilly”), Shionogi & Co. Ltd. (“Shionogi”), or the Company that would invalidate
any of the pending patent application claims directed to the treatment of cardiovascular diseases
or a condition associated with cardiovascular disease using one or more sPLA2 inhibitors. The
patents and patent applications referred to in the prior three sentences include those currently
licensed or owned by the Company.

          4.10 Compliance with Other Instruments. Neither the Company nor the Subsidiary is or with
the giving of notice or lapse of time or both, will be, (a) in violation of its certificate or
articles of incorporation, by-laws or other organizational documents or (b) in violation

11

 

of or in
default under any agreement, lease, contract, indenture or other instrument or obligation to which
it is a party or by which it, or any of its properties, is bound and, solely with respect to this
clause (b), which violation or default would have a Material Adverse Effect. The execution and
delivery of this Agreement and the consummation of the transactions herein contemplated and the
fulfillment of the terms hereof will not conflict with or result in a breach of (i) any of the
terms or provisions of, or constitute a default under, any indenture, mortgage, deed of trust or
other agreement or instrument to which the Company or the Subsidiary is a party or by which the
Company or the Subsidiary or any of their respective properties is bound, except for such
conflicts, breaches or defaults that would not, individually or in the aggregate, have a Material
Adverse Effect, (ii) the certificate or articles of incorporation or by-laws of the Company or
(iii) any law, order, rule or regulation judgment, order, writ or decree applicable to the Company
or the Subsidiary of any court or of any government, regulatory body or administrative agency or
other governmental body having jurisdiction, except for such conflicts or breaches that would not,
individually or in the aggregate, have a Material Adverse Effect.

          4.11 Indebtedness. Neither the Company nor its subsidiaries has any outstanding
Indebtedness. “Indebtedness” means, without duplication all (a) indebtedness for borrowed
money, (b) notes payable, whether or not representing obligations for borrowed money, (c)
obligations representing the deferred purchase price for property or services, (d) obligations
secured by any mortgage or lien on property owned or acquired subject to such mortgage or lien,
whether or not the liability secured thereby shall have been assumed, (e) all guaranties,
endorsements and other contingent obligations, in respect of Indebtedness of others, whether or not
the same are or should be so reflected in the Company’s balance sheet, except guaranties by
endorsement of negotiable instruments for deposit or collection or similar transactions in the
ordinary course of business and (f) that portion of any lease payments due under leases required to
be capitalized in accordance with generally accepted accounting principles consistently applied,
provided however, that Indebtedness shall not include trade payables and trade debt.

          4.12 Litigation. There is no action, suit, proceeding or investigation pending or, to the
Company’s knowledge, currently threatened in writing against the Company that questions the
validity of this Agreement and the Securities, or the right of the Company to enter into any of
such agreements, or to consummate the transactions contemplated hereby or thereby, or which would
reasonably be expected to result, either individually or in the aggregate, in any material adverse
change in the assets, condition, affairs or prospects of the Company, financially or otherwise, or
any change in the current equity ownership of the Company, nor is the Company aware that there is
any basis for any of the foregoing (a “Material Adverse Change”). The foregoing includes,
without limitation, actions pending or, to the Company’s knowledge, threatened in writing involving
the prior employment of any of the Company’s employees, their use in connection with the Company’s
business of any information or techniques allegedly proprietary to any of their former employers,
or their obligations under any agreements with
prior employers. The Company is not a party or to its knowledge subject to the provisions of
any order, writ, injunction, judgment or decree of any court or government agency or
instrumentality. There is no action, suit, proceeding or investigation by the Company currently
pending or which the Company intends to initiate.

12

 

          4.13 Employees. The Company has no collective bargaining agreements with any of its
employees. There is no labor union organizing activity pending or, to the Company’s knowledge,
threatened with respect to the Company. The Company is not a party to or bound by any currently
effective employment contract, deferred compensation arrangement, bonus plan, incentive plan,
profit sharing plan, retirement agreement or other employee compensation plan or agreement, nor has
the Company ever maintained or contributed to any employee benefit plan subject to the Employee
Retirement Income Security Act of 1974 (“ERISA”). The Company has never contributed to any
“multi-employer plan” as such term is defined in ERISA. To the Company’s knowledge, no employee of
the Company, nor any consultant with whom the Company has contracted, is in violation of any term
of any employment contract, proprietary information agreement or any other agreement relating to
the right of any such individual to be employed by, or to contract with, the Company; and to the
Company’s knowledge the continued employment by the Company of its present employees, and the
performance of the Company’s contracts with its independent contractors, will not result in any
such violation. The Company has not received any notice alleging that any such violation has
occurred. No employee of the Company has been granted the right to continued employment by the
Company or to any material compensation following termination of employment with the Company. The
Company is not aware that any officer, key employee or group of employees intends to terminate his,
her or their employment with the Company, nor does the Company have a present intention to
terminate the employment of any officer, key employee or group of employees. There are no actions
pending, or to the Company’s knowledge, threatened, by any former or current employee concerning
such person’s employment by the Company.

          4.14 Registration Rights and Voting Rights. Except as may be required by the Rights
Agreement, the Company is presently not under any obligation, and has not granted any rights, to
file a registration statement with the United States Securities and Exchange Commission (the
“SEC”) in respect of any of the Company’s presently outstanding securities or any of its
securities that may hereafter be issued. To the Company’s knowledge, no stockholder of the Company
has entered into any agreement with respect to the voting of equity securities of the Company.

          4.15 Compliance with Laws; Permits. To its knowledge, the Company is not in violation
of any applicable statute, rule, regulation, order or restriction of any domestic or foreign
government or any instrumentality or agency thereof in respect of the conduct of its business or
the ownership of its properties which violation would cause a Material Adverse Change. No United
States domestic governmental orders, permissions, consents, approvals or authorizations are
required to be obtained and no registrations or declarations are required to be filed in connection
with the execution and delivery of this Agreement or the issuance of the Shares, except such as
have been duly and validly obtained or filed, or with respect to any filings that must be made
after the Closing, as will be filed in a timely manner. The Company and the Subsidiary possesses
such permits, certificates, licenses, approvals, consents and other authorizations (collectively,
“Governmental Licenses”) issued by the appropriate federal, state, local or
foreign
regulatory agencies or bodies necessary to conduct the business of the Company as currently
conducted and as currently contemplated to be conducted, including without limitation, all such
registrations, approvals, certificates,
authorizations and permits required by the United States Food and Drug Administration (the
“FDA”) and/or other federal, state, local or

 

13

 

foreign agencies or bodies engaged in the
regulation of clinical trials, pharmaceuticals, or biohazardous substances or materials, except
where the failure so to possess would not, singly or in the aggregate, have a Material Adverse
Effect; the Company is in compliance with the terms and conditions of all such Governmental
Licenses, except where the failure so to comply would not, singly or in the aggregate, have a
Material Adverse Effect; all of the Governmental Licenses are valid and in full force and effect,
except when the invalidity of such Governmental Licenses or the failure of such Governmental
Licenses to be in full force and effect would not, singly or in the aggregate, have a Material
Adverse Effect; and the Company has not received any written notice of proceedings relating to the
revocation or modification of any such Governmental Licenses which, singly or in the aggregate, if
the subject of an unfavorable decision, ruling or finding, would have a Material Adverse Effect.
Where required by applicable laws and regulations of the FDA, the Company has submitted to the FDA
an Investigational New Drug Application or amendment or supplement thereto for a clinical trial it
has conducted or sponsored or is conducting or sponsoring, except where such failure would not,
singly or in the aggregate, have a Material Adverse Effect; all such submissions were in material
compliance with applicable laws and rules and regulations when submitted and no material
deficiencies have been asserted by the FDA with respect to any such submissions, except any
deficiencies which could not, singly or in the aggregate, have a Material Adverse Effect. The
Company has operated and currently is in compliance with the United States Federal Food, Drug, and
Cosmetic Act, all applicable rules and regulations of the FDA and other federal, state, local and
foreign governmental bodies exercising comparable authority, except where the failure to so operate
or be in compliance would not, individually or in the aggregate, have a Material Adverse Effect.
The preclinical and clinical studies conducted by or, to the Company’s knowledge, on behalf of the
Company were, and, if still pending, are being, conducted in all material respects in accordance
with the protocols submitted to the FDA, and all applicable laws and regulations; and the Company
has not received any written notice or correspondence from the FDA or any foreign, state or local
governmental body exercising comparable authority requiring the termination, suspension, or
clinical hold of any tests or preclinical or clinical studies, or such written notice or
correspondence from any Institutional Review Board or comparable authority requiring the
termination or suspension of a clinical study, conducted by or on behalf of the Company, which
termination, suspension, or clinical hold would reasonably be expected to have a Material Adverse
Effect.

          4.16 Environmental and Safety Laws. To its knowledge, the Company is not in violation
of any applicable statute, law or regulation relating to the environment or occupational health and
safety, and to its knowledge, no material expenditures are or will be required in order to comply
with any such existing statute, law or regulation. No Hazardous Materials (as defined below) are
used or have been used, stored, or disposed of by the Company or, to the Company’s knowledge, by
any other person or entity on any property owned, leased or used by the Company. For the purposes
of the preceding sentence, “Hazardous Materials” shall mean (a) materials which are listed or
otherwise defined as “hazardous” or “toxic” under any applicable local, state, federal and/or
foreign laws and regulations that govern the existence and/or remedy of contamination on property,
the protection of the environment from contamination, the control of hazardous wastes, or other
activities
involving hazardous substances, including building materials, or (b) any petroleum products or
nuclear materials.

14

 

          4.17 Material Changes Since September 30, 2009, there has not been:

               (a) any change in the assets, liabilities, financial condition, or operating results of the
Company from that reflected in the Financial Statements, except changes in the ordinary course of
business that have not been and are not expected to be, individually or in the aggregate,
materially adverse;

               (b) any damage, destruction, or loss, whether or not covered by insurance, that would cause a
Material Adverse Change;

               (c) any waiver or compromise by the Company of a valuable right or of a material debt owed to
it;

               (d) any satisfaction or discharge of any lien, claim, or encumbrance or payment of any
obligation by the Company, except in the ordinary course of business and that would not cause a
Material Adverse Change;

               (e) any material change or amendment to a material contract or arrangement by which the
Company or any of its assets or properties is bound or subject;

               (f) any material change in any compensation arrangement or agreement with any employee,
officer, director, or stockholder;

               (g) any sale, assignment, or transfer of any proprietary assets;

               (h) any resignation or termination of employment of any officer, key employee, or key
consultant, or any group of key employees or consultants, of the Company;

               (i) any mortgage, pledge, transfer of a security interest in, or lien created by the Company,
with respect to any of its material properties or assets, except liens for taxes not yet due or
payable;

               (j) any material change in the contingent obligations of the Company by way of guaranty,
endorsement, indemnity, warranty, or otherwise;

               (k) any declaration, setting aside of payment, or other distribution in respect of any of the
Company’s capital stock, or any direct or indirect redemption, purchase, or other acquisition of
any of such stock by the Company; or

               (l) any agreement or commitment by the Company to do any of the things described in this
Section 4.17.

          4.18 Offering Valid. Assuming the accuracy of the representations and warranties of
the Purchasers contained in Section 5 hereof, the offer, sale and issuance of the Securities will
be exempt from the registration requirements of the Securities Act, and will have been registered
or qualified (or are exempt from registration and qualification) under the

15

 

registration, permit or
qualification requirements of all applicable state securities laws. Neither the Company nor any
agent on its behalf has solicited or will solicit any offers to sell or has offered to sell or will
offer to sell all or any part of the Securities to any person or persons so as to bring the sale of
such Securities by the Company within the registration provisions of the Securities Act or any
state securities laws.

          4.19 Title to Properties and Assets; Liens, Etc. The Company has good and marketable
title to its properties and assets, including the properties and assets reflected in the most
recent balance sheet included in the Financial Statements, and good title to its leasehold estates,
in each case subject to no mortgage, pledge, lien, lease, encumbrance or charge, other than
(a) those resulting from taxes which have not yet become delinquent, (b) minor liens and
encumbrances which do not materially detract from the value of the property subject thereto or
materially impair the operations of the Company, and (c) those that have otherwise arisen in the
ordinary course of business.

          4.20 Tax. The Company and the Subsidiary have filed all federal, state, local and foreign tax returns which have been required to be filed and have paid all taxes indicated by such returns and all assessments received by them or any of them to the extent that such taxes have become due and are not being contested in good faith and for which an adequate
reserve for accrual has been established in accordance with GAAP, except as would not have a Material Adverse Effect.
All material tax liabilities have been adequately provided for in the financial statements of the Company, and the Company does not know of any actual or proposed additional material tax assessments.

          4.21 Investment Company Act. Neither the Company nor the Subsidiary is or, after
giving effect to the offering and sale of the Shares contemplated hereunder and the application of
the net proceeds from such sale, will be an “investment company” within the meaning of such term
under the Investment Company Act of 1940 as amended (the “1940 Act”), and the rules and
regulations of the Securities and Exchange Commission thereunder.

          4.22 Internal Controls and Disclosures. The Company and the Subsidiary maintain a
system of internal accounting controls sufficient to provide reasonable assurances that (i)
transactions are executed in accordance with
management’s general or specific authorization; (ii) transactions are recorded as necessary to
permit preparation of financial statements in conformity with GAAP and to maintain accountability
for assets; (iii) access to assets is permitted only in accordance with management’s general or
specific authorization; and (iv) the recorded accountability for assets is compared with existing
assets at reasonable intervals and appropriate action is taken with respect to any differences.
The Company has established and maintains “disclosure controls and procedures” (as defined in Rules
13a-14(c) and 15d-14(c) under the Exchange Act); the Company’s “disclosure controls and procedures”
are reasonably designed to ensure that all information (both financial and non-financial) required
to be disclosed by the Company in the reports that it files or submits under the Exchange Act is
recorded, processed, summarized and reported within the time periods specified in the rules and
regulations of the Exchange Act, and that all such information is accumulated and communicated to
the Company’s management as appropriate to allow timely decisions regarding required disclosure and
to make the

16

 

certifications of the Chief Executive Officer and Chief Financial Officer of the
Company required under the Exchange Act with respect to such reports.

          4.23 Money Laundering Laws. The operations of the Company and the Subsidiary are and
have been conducted at all times in compliance in all material respects with applicable financial
record-keeping and reporting requirements of the Currency and Foreign Transactions Reporting Act of
1970, as amended, applicable money laundering statutes and applicable rules and regulations
thereunder (collectively, the “Money Laundering Laws”), and no action, suit or proceeding
by or before any court or governmental agency, authority or body or any arbitrator involving the
Company or the Subsidiary with respect to the Money Laundering Laws is pending or, to the Company’s
knowledge, threatened.

          4.24 OFAC. Neither the Company nor, to the Company’s knowledge, any director,
officer, agent, employee or affiliate of the Company is currently subject to any U.S. sanctions
administered by the Office of Foreign Assets Control of the U.S. Treasury Department
(“OFAC”); and the Company will not directly or indirectly use the proceeds of the offering
of the Shares, or lend, contribute or otherwise make available such proceeds to any subsidiary,
joint venture partner or other person or entity, for the purpose of financing the activities of any
person currently subject to any U.S. sanctions administered by OFAC.

          4.25 Insurance. The Company and the Subsidiary carry, or are covered by, insurance in such
amounts and covering such risks as the Company reasonably deems adequate for the conduct of their
respective businesses and the value of their respective properties and as is customary for
companies engaged in similar businesses and in similar industries.

          4.26 Foreign Corrupt Practices Act. Neither the Company nor the Subsidiary nor, to
the Company’s knowledge, any director, officer, agent, employee or affiliate of the Company or the
Subsidiary is aware of or has taken any action, directly or indirectly, that would result in a
violation by such persons of the Foreign Corrupt Practices Act of 1977, as amended, and the rules
and regulations thereunder (the “FCPA”),
including, without limitation, making use of the mails or any means or instrumentality of
interstate commerce corruptly in furtherance of an offer, payment, promise to pay or authorization
of the payment of any money, or other property, gift, promise to give, or authorization of the
giving of anything of value to any “foreign official” (as such term is defined in the FCPA) or any
foreign political party or official thereof or any candidate for foreign political office, in
contravention of the FCPA and the Company, the Subsidiary and their respective affiliates have
conducted their businesses in compliance in all material respects with the FCPA and have instituted
and maintain policies and procedures designed to ensure, and which are reasonably expected to
continue to ensure, continued compliance therewith. Neither the Company nor the Subsidiary has
made any contribution or other payment to any official of, or candidate for, any federal, state or
foreign office in violation of any law.

          4.27 No Integration. The Company has not sold or issued and will not sell or issue
any securities that would be integrated with the offering of the Shares pursuant to the Securities
Act, the rules and regulations promulgated thereunder, or the interpretations thereof by the
Securities and Exchange Commission.

17

 

          4.28 Full Disclosure. The Company has provided the Purchasers with all information
requested by such Purchasers in connection with their decision to purchase the Securities. Neither
this Agreement, the exhibits hereto, the Notes nor any other document delivered by the Company to
the Purchasers or their attorneys or agents in connection herewith or therewith at the Closing or
with the transactions contemplated hereby or thereby, contain any untrue statement of a material
fact nor, to the Company’s knowledge, omit to state a material fact necessary in order to make the
statements contained herein or therein not misleading.

     5. Representations and Warranties of the Purchasers. Each Purchaser hereby represents
and warrants to the Company, severally and not jointly, as follows (provided that such
representations and warranties do not lessen or obviate the representations and warranties of the
Company set forth in this Agreement):

          5.1 Requisite Power and Authority. Purchaser has all necessary power and authority to
execute and deliver this Agreement and to carry out its provisions. All action on Purchaser’s part
required for the lawful execution and delivery of this Agreement has been taken. Upon its
execution and delivery, this Agreement will be a valid and binding obligation of Purchaser,
enforceable in accordance with its terms, except (a) as limited by applicable bankruptcy,
insolvency, reorganization, moratorium or other laws of general application affecting enforcement
of creditors’ rights and (b) as limited by general principles of equity that restrict the
availability of equitable remedies.

          5.2 Investment Representations.

               (a) Purchaser Bears Economic Risk. Purchaser has substantial experience in evaluating
and investing in securities of companies similar to the Company so that
it is capable of evaluating the merits and risks of its investment in the Company and has the
capacity to protect its own interests. Purchaser must bear the economic risk of this investment
indefinitely unless the Securities are registered pursuant to the Securities Act, or an exemption
from registration is available. Purchaser understands that the Company has no present intention of
registering the Securities. Purchaser also understands that there is no assurance that any
exemption from registration under the Securities Act will be available and that, even if available,
such exemption may not allow Purchaser to transfer all or any portion of the Securities under the
circumstances, in the amounts or at the times Purchaser might propose.

               (b) Acquisition for Own Account. Purchaser is acquiring the Securities for
Purchaser’s own account for investment only, and not with a view towards their distribution. If
other than an individual, each Purchaser also represents it has not been organized solely for the
purpose of acquiring the Securities.

               (c) Purchaser Can Protect Its Interest. Purchaser represents that by reason of its,
or of its management’s, business or financial experience, Purchaser has the capacity to protect its
own interests in connection with the transactions contemplated in this Agreement. Further,
Purchaser is aware of no publication of any advertisement in connection with the transactions
contemplated in the Agreement.

18

 

               (d) Accredited Investor. Each Purchaser is an “accredited investor” within the
meaning of Rule 501 of Regulation D of the SEC, as presently in effect.

               (e) Company Information. Purchaser has had an opportunity to discuss the Company’s
business, management and financial affairs with directors, officers and management of the Company
and has had the opportunity to review the Company’s operations and facilities. Purchaser has also
had the opportunity to ask questions of and receive answers from, the Company and its management
regarding the terms and conditions of this investment.

               (f) Rule 144. Purchaser acknowledges and agrees that the Securities are “restricted
securities” as defined in Rule 144 promulgated under the Securities Act as in effect from time to
time and must be held indefinitely unless they are subsequently registered under the Securities Act
or an exemption from such registration is available. Purchaser has been advised or is aware of the
provisions of Rule 144, which permits limited resale of securities purchased in a private placement
subject to the satisfaction of certain conditions, including, among other things: the availability
of certain current public information about the Company, the resale occurring following the
required holding period under Rule 144 and the number of securities being sold during any
three-month period not exceeding specified limitations.

               (g) Residence. If Purchaser is an individual, then Purchaser resides in the state or
province identified in the address of Purchaser set forth on the Schedule of Purchasers, as
applicable; if Purchaser is a partnership, corporation, limited liability company or other entity,
then the office or offices of Purchaser in which its investment decision was made is located at the
address or addresses of Purchaser set forth on the Schedule of Purchasers, as applicable.

               (h) Foreign Purchasers. If Purchaser is not a United States person (as defined by
Section 7701(a)(30) of the Internal Revenue Code of 1986, as amended), Purchaser hereby represents
that it has satisfied itself as to the full observance of the laws of its jurisdiction in
connection with any invitation to subscribe for the Securities or any use of this Agreement,
including (i) the legal requirements within its jurisdiction for the purchase of the Securities,
(ii) any foreign exchange restrictions applicable to such purchase, (iii) any government or other
consents that may need to be obtained, and (iv) the income tax and other tax consequences, if any,
that may be relevant to the purchase, holding, redemption, sale or transfer of the Securities. The
Company’s offer and sale and Purchaser’s subscription and payment for and continued beneficial
ownership of the Securities will not violate any applicable securities or other laws of Purchaser’s
jurisdiction.

          5.3 Further Limitations on Disposition. Without in any way limiting the
representations and warranties set forth above, each Purchaser further agrees not to make any
disposition of all or any portion of the Securities unless and until the transferee has agreed in
writing for the benefit of the Company to be bound by and to deliver the representations contained
in this Section 5 and all restrictions on transfer as set forth in the Rights Agreement.

          5.4 Legends. It is understood that the Securities may bear the following legend:

19

 

“THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED. THEY MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED, HYPOTHECATED,
OR OTHERWISE TRANSFERRED EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION
STATEMENT UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR AN OPINION OF
COUNSEL SATISFACTORY TO THE COMPANY THAT REGISTRATION IS NOT REQUIRED UNDER
SUCH ACT OR UNLESS SOLD PURSUANT TO RULE 144 UNDER SUCH ACT.”

     6. State Commissioners of Corporations.

          6.1 California Corporate Securities Law. THE SALE OF THE SECURITIES WHICH ARE THE
SUBJECT OF THIS AGREEMENT HAS NOT BEEN QUALIFIED WITH THE COMMISSIONER OF CORPORATIONS OF THE STATE
OF CALIFORNIA AND THE ISSUANCE OF SUCH SECURITIES OR THE PAYMENT OR RECEIPT OF ANY PART OF THE
CONSIDERATION FOR SUCH SECURITIES PRIOR TO SUCH QUALIFICATION IS UNLAWFUL, UNLESS THE SALE OF
SECURITIES IS EXEMPT FROM QUALIFICATION BY SECTION 25100, 25102 OR 25105 OF THE CALIFORNIA
CORPORATIONS CODE. THE RIGHTS OF ALL PARTIES TO THIS AGREEMENT ARE EXPRESSLY CONDITIONED UPON SUCH
QUALIFICATION BEING OBTAINED, UNLESS THE SALE IS SO EXEMPT.

     7. Defaults and Remedies.

          7.1 Events of Default. The following events shall be considered Events of Default
with respect to each Note:

               (a) The Company shall default in the payment of any part of the principal or unpaid accrued
interest on the Note after the Maturity Date or at a date fixed by acceleration or otherwise;

               (b) The Company shall make an assignment for the benefit of creditors or shall file a
voluntary petition for bankruptcy, or shall file any petition or answer seeking for itself any
reorganization, arrangement, composition, readjustment, dissolution or similar relief under any
present or future statute, law or regulation, or shall file any answer admitting the material
allegations of a petition filed against the Company in any such proceeding, or shall seek or
consent to or acquiesce in the appointment of any trustee, receiver or liquidator of the Company,
or of all or any substantial part of the properties of the Company, or the Company or its
respective directors or majority stockholders shall take any action looking to the dissolution or
liquidation of the Company;

               (c) Within thirty (30) days after the commencement of any proceeding against the Company
seeking any bankruptcy reorganization, arrangement, composition, readjustment, liquidation,
dissolution or similar relief under any present or future statute, law or

20

 

regulation, such
proceeding shall not have been dismissed, or within thirty (30) days after the appointment without
the consent or acquiescence of the Company of any trustee, receiver or liquidator of the Company or
of all or any substantial part of the properties of the Company, such appointment shall not have
been vacated;

               (d) The Company shall fail to observe or perform any other obligation to be observed or
performed by it under this Agreement, the Notes or the Warrants within ten (10) days after written
notice from the Required Note Holders to perform or observe the obligation;

               (e) Any representation or warranty under Section 4 of this Agreement shall be false,
incorrect, incomplete or misleading in any material respect when made; or

               (f) The occurrence of any Event of Default (as such term is defined in the July 2009 Purchase
Agreement) pursuant to the July 2009 Note Purchase Agreement.

          7.2 Remedies. Upon the occurrence of an Event of Default under Section 7.1 hereof, at
the option and upon the declaration of the Required Note Holders and upon written notice to the
Company (which election and notice shall not be required in the case of an Event of Default under
Section 7.1(b) or 7.1(c) hereof), the entire unpaid principal and accrued and unpaid interest on
each Note shall be forthwith due and payable, and the holder of each such Note may, immediately and
without expiration of any period of grace, enforce payment of all amounts due and owing under
such Note and exercise any and all other remedies granted to it at law, in equity or otherwise.

     8. Covenants of the Company.

          8.1 Indebtedness. Except to the extent the provisions of this Section are waived in
any instance by the Required Note Holders, the Company covenants and agrees that so long as any
Note is outstanding, it shall not: create, incur, assume or suffer to exist any liability with
respect to Indebtedness except for: (a) the Notes, (b) current liabilities and trade payables,
other than for borrowed money, which are incurred in the ordinary course of business, and (c) any
Indebtedness outstanding as of the date of this Agreement.

          8.2 Use of Proceeds. Proceeds raised through the sale of the Initial Notes shall be
used for general working capital needs consistent with financial budgets approved from time to time
by the Board, including the majority of the directors elected by the holders of the Series A-1
Preferred Stock, Series A-2 Preferred Stock, Series B-1 Preferred Stock and the Series B-2
Preferred Stock.

     9. Conditions to Closing.

          9.1 Conditions to Purchasers’ Obligations at the Closing. Purchasers’ obligations to
purchase the Initial Notes at the Closing are subject to the satisfaction, at or prior to the
Closing, of the following conditions:

21

 

               (a) Representations and Warranties True; Performance of Obligations. The
representations and warranties made by the Company in Section 4 hereof shall be true and correct as
of the Closing Date with the same force and effect as if they had been made as of the Closing Date,
and the Company shall have performed all obligations and conditions herein required to be performed
or observed by it on or prior to the Closing.

               (b) Consents, Permits, and Waivers. The Company shall have obtained any and all
consents, permits and waivers necessary or appropriate for consummation of the transactions
contemplated by the Agreement (except for such as may be properly obtained subsequent to the
Closing).

               (c) Filing of Certificate of Amendment to Certificate of Incorporation. A Certificate
of Amendment to the Company’s Restated Certificate of Incorporation shall have been filed with the
Secretary of State of the State of Delaware and shall continue to be in full force and effect as of
the Closing Date.

               (d) Corporate Documents. The Company shall have delivered to Purchasers or their
counsel copies of all corporate documents of the Company as Purchasers shall reasonably request.

               (e) Reservation of Shares of Series B-2 Preferred. The shares of Series B-2 Preferred
issuable pursuant to Section 2.3(c) and Section 2.3(i) hereof shall have been duly authorized and
reserved for issuance upon such election.

               (f) Compliance Certificate. The Company shall have delivered to Purchasers a
Compliance Certificate, executed by the President of the Company, dated the Closing Date, to the
effect that the conditions specified in subsections (a) and (b) of this Section 9.1 have been
satisfied.

               (g) Ancillary Agreements. The Ancillary Agreements substantially in the forms attached
hereto shall have been executed and delivered by the parties thereto.

               (h) Secretary’s Certificate. Purchasers shall have received from the Company’s
Secretary, a certificate having attached thereto (i) the Company’s Restated Certificate as in
effect at the time of the Closing, (ii) the Company’s Bylaws as in effect at the time of the
Closing, (iii) resolutions approved by the Board authorizing the transactions contemplated hereby,
and (iv) good standing certificates (including tax good standing) with respect to the Company from
the applicable authority(ies) in Delaware and any other jurisdiction in which the Company is
qualified to do business, dated a recent date before the Closing.

               (i) Proceedings and Documents. All corporate and other proceedings in connection with
the transactions contemplated at the Closing hereby and all documents and instruments incident to
such transactions shall be reasonably satisfactory in substance and form to Purchasers and their
special counsel, and Purchasers and their special counsel shall have received all such counterpart
originals or certified or other copies of such documents as they may reasonably request.

22

 

          9.2 Conditions to Obligations of the Company at the Closing. The Company’s obligation to
issue and sell the Initial Notes at the Closing is subject to the satisfaction or waiver, on or
prior to the Closing, of the following conditions.

               (a) Representations and Warranties True; Performance of Obligations. The
representations and warranties made by the Purchasers shall be true and correct as of the Closing
Date with the same force and effect as if they had been made as of the Closing Date, and the
Purchasers shall have performed all obligations and conditions herein required to be performed or
observed by them on or prior to the Closing.

     10. Miscellaneous.

          10.1 Successors and Assigns. Except as otherwise provided herein, the terms and conditions of this Agreement shall inure
to the benefit of and be binding upon the respective successors and assigns of the parties,
provided, however, that the Company may not assign its obligations under this
Agreement without the written consent of the Required Note Holders. Nothing in this Agreement,
express or implied, is intended to confer upon any party other than the parties hereto or their
respective successors and assigns any rights, remedies, obligations or liabilities under or by
reason of this Agreement, except as expressly provided in this Agreement.

          10.2 Governing Law. This Agreement shall be governed by and construed under the laws
of the State of California in all respects as such laws are applied to agreements among California
residents entered into and performed entirely within California, without giving effect to conflict
of law principles thereof. The parties agree that any action brought by either party under or in
relation to this Agreement, including without limitation to interpret or enforce any provision of
this Agreement, shall be brought in, and each party agrees to and does hereby submit to the
jurisdiction and venue of, any state or federal court located in the County of Alameda, California.

          10.3 Facsimile; Counterparts. This Agreement may be executed by facsimile and in two
or more counterparts, each of which shall be deemed an original, but all of which together shall
constitute one and the same instrument.

          10.4 Titles and Subtitles. The titles and subtitles used in this Agreement are used
for convenience only and are not to be considered in construing or interpreting this Agreement.

          10.5 Notices. All notices required or permitted hereunder shall be in writing and
shall be deemed effectively given: (a) upon personal delivery to the party to be notified, (b) when
sent by confirmed electronic mail, telex or facsimile if sent during normal business hours of the
recipient, if not, then on the next business day, (c) five (5) days after having been sent by
registered or certified mail, return receipt requested, postage prepaid, or (d) one (1) day after
deposit with a nationally recognized overnight courier, specifying next day delivery, with written
verification of receipt. All communications shall be sent to the Company at the address as set
forth on the signature page hereof and to Purchaser at the address set forth on the Schedule of
Purchasers attached hereto or at such other address or electronic mail address as the Company

23

 

or Purchaser may designate by ten (10) days advance written notice to the other parties hereto. If
notice is given to the Company, a copy shall also be sent to Bradley A. Bugdanowitz, Goodwin
Procter, LLP, Three Embarcadero Center, 24th Floor, San Francisco, CA 94111 (which copy shall not
constitute notice to the Company).

          10.6 Finder’s Fee. Each party represents that it neither is nor will be obligated for any finder’s fee or
commission in connection with this transaction. Purchaser agrees to indemnify and to hold harmless
the Company from any liability for any commission or compensation in the nature of a finder’s fee
(and the costs and expenses of defending against such liability or asserted liability) for which
Purchaser or any of its officers, partners, employees or representatives is responsible. The
Company agrees to indemnify and hold harmless Purchaser from any liability for any commission or
compensation in the nature of a finder’s fee (and the costs and expenses of defending against such
liability or asserted liability) for which the Company or any of its officers, employees or
representatives is responsible.

          10.7 Expenses. Each party shall pay all costs and expenses that it incurs with
respect to the negotiation, execution, delivery and performance of the Agreement; provided
that the Company shall pay the reasonable fees and expenses of Wilson Sonsini Goodrich & Rosati,
special counsel for certain of the Purchasers, in an amount not to exceed $5,000.

          10.8 Entire Agreement; Amendments and Waivers. This Agreement, the Notes and the
Warrants and the other documents delivered pursuant hereto constitute the full and entire
understanding and agreement between the parties with regard to the subjects hereof and thereof.
The Company’s agreements with each of the Purchasers are separate agreements, and the sales of the
Initial Notes to each of the Purchasers are separate sales. Nonetheless, any term of this
Agreement (other than Section 2.5 of this Agreement), the Notes or the Warrants may be amended and
the observance of any term of this Agreement (other than Section 2.5 of this Agreement), the Notes
or the Warrants may be waived (either generally or in a particular instance and either
retroactively or prospectively), only with the written consent of the Company and the Required Note
Holders, provided, however, that any amendment of any term of this Agreement, the
Notes or the Warrants that increases a Purchaser’s obligations or that disproportionately affects
such Purchaser or disadvantages such Purchaser in a way that such amendment does not disadvantage
all other Purchasers, shall require the written consent of that Purchaser. Any waiver or amendment
effected in accordance with this Section shall be binding upon each party to this Agreement and any
holder of any Note or Warrant issued under this Agreement at the time outstanding and each future
holder of all such Notes or Warrants.

          10.9 Effect of Amendment or Waiver. Each Purchaser acknowledges that by the operation
of Section 10.8 hereof, the Required Note Holders will have the right and power to diminish or
eliminate all rights of such Purchaser under this Agreement and each Note and Warrant issued to
such Purchaser (including, without limitation, such Purchaser’s right to receive principal and
interest as due under each Note).

          10.10 Severability. If one or more provisions of this Agreement are held to be
unenforceable under applicable law, such provision shall be excluded from this Agreement and the
balance of the
Agreement shall be interpreted as if such provision were so excluded and shall be enforceable
in accordance with its terms.

24

 

          10.11 Stock Purchase Agreement. Each Purchaser understands and agrees that the
conversion of the Notes into and exercise of the Warrants for Conversion Shares or for shares of
Series B-2 Preferred issuable pursuant to Section 2.3(c) hereof may require such Purchaser’s
execution of certain agreements (in form reasonably agreeable to the Purchaser) relating to the
purchase and sale of such securities as well as registration, co-sale, rights of first refusal,
rights of first offer and voting rights, if any, relating to such securities.

          10.1 Registrable Securities. The Company and the undersigned Purchasers, constituting
the holders of at least a majority of the Registrable Securities (as defined in the Rights
Agreement), agree and acknowledge that the Conversion Shares, when issued, shall be deemed
“Registrable Securities” for all purposes under the Rights Agreement. By execution of this
Agreement, each Purchaser expressly waives, on behalf of itself and all holders of such rights, (a)
any right of first refusal or other participation right with respect to the Securities granted to
such Purchaser pursuant to Section 4 of the Rights Agreement and (b) all rights it may have to
notice of such sale of the Securities pursuant to this Agreement pursuant to Sections 4.2 and 4.4
of the Rights Agreement.

          10.2 Exculpation Among Purchasers. Each Purchaser acknowledges that it is not
relying upon any person, firm, corporation or stockholder, other than the Company and its officers
and directors in their capacities as such, in making its investment or decision to invest in the
Company. Each Purchaser agrees that no other Purchaser nor the respective controlling persons,
officers, directors, partners, agents, stockholders or employees of any other Purchaser shall be
liable for any action heretofore or hereafter taken or omitted to be taken by any of them in
connection with the purchase and sale of the Securities.

          10.3 Acknowledgement. In order to avoid doubt, it is acknowledged that each Purchaser
shall be entitled to the benefit of all adjustments in the number of shares of Common Stock of the
Company issuable upon conversion of the Preferred Stock of the Company or as a result of any
splits, recapitalizations, combinations or other similar transaction affecting the Common Stock or
Preferred Stock underlying the Conversion Shares or the shares of Series B-2 Preferred issuable
pursuant to Section 2.3(c) hereof that occur prior to the conversion of the Notes or exercise of
the Warrants.

          10.4 Further Assurance. From time to time, the Company shall execute and deliver to
the Purchasers such additional documents and shall provide such additional information to the
Purchasers as any Purchaser may reasonably require to carry out the terms of this Agreement and the
Notes and any
agreements executed in connection herewith or therewith, or to be informed of the financial
and business conditions and prospects of the Company.

          10.5 Waiver of Jury Trial. TO THE EXTENT EACH MAY LEGALLY DO SO, EACH PARTY HERETO
HEREBY EXPRESSLY WAIVES ANY RIGHT TO TRIAL BY JURY OF ANY CLAIM, DEMAND, ACTION, CAUSE OF ACTION,
OR PROCEEDING ARISING UNDER OR WITH RESPECT TO THIS AGREEMENT, OR IN ANY WAY CONNECTED WITH, OR
RELATED TO, OR INCIDENTAL TO, THE DEALING OF THE PARTIES HERETO WITH RESPECT TO THIS AGREEMENT, OR
THE TRANSACTIONS RELATED THERETO, IN EACH CASE WHETHER NOW EXISTING OR HEREAFTER ARISING, AND
IRRESPECTIVE OF WHETHER SOUNDING IN CONTRACT, TORT, OR

25

 

OTHERWISE. TO THE EXTENT EACH MAY LEGALLY
DO SO, EACH PARTY HERETO HEREBY AGREES THAT ANY SUCH CLAIM, DEMAND, ACTION, OR PROCEEDING SHALL BE
DECIDED BY A COURT TRIAL WITHOUT A JURY AND THAT EITHER PARTY HERETO MAY FILE AN ORIGINAL
COUNTERPART OR A COPY OF THIS AGREEMENT WITH ANY COURT AS WRITTEN EVIDENCE OF THE CONSENT OF ANY
OTHER PARTY HERETO TO THE WAIVER OF ITS RIGHT TO TRIAL BY JURY.

          10.6 Dispute Resolution. Any dispute arising out of or in connection with the transactions
contemplated by this Agreement will be resolved solely by confidential binding arbitration in San
Francisco, California according to the then current commercial arbitration rules of JAMS. Each
party shall bear its own attorneys’ fees, expert witness fees, and costs connected to such
arbitration.

[Remainder of Page Intentionally Left Blank]

26

 

          IN WITNESS WHEREOF, the parties hereto have executed this Note Purchase Agreement as of the
date set forth in the first paragraph hereof.

	 	 	 	 	 
	COMPANY:	 	 
	 
	 	 	 	 
	ANTHERA PHARMACEUTICALS, INC.	 	 
	 
	 	 	 	 
	By:

	 	/s/ Paul F. Truex	 	 
	 

	 	 	 	 
	 

	 	Paul F. Truex	 	 
	 

	 	President and Chief Executive Officer
	 	 

			
	Address:	 	25801 Industrial Blvd.

Suite B

Hayward, CA 94545

	 	 	 	 	 
	 	PURCHASERS:

VANTAGEPOINT VENTURE PARTNERS IV
(Q), L.P.

VANTAGEPOINT VENTURE PARTNERS
IV, L.P.

VANTAGEPOINT VENTURE PARTNERS IV

     PRINCIPALS FUND, L.P.

 	 
	 	By:	VantagePoint Venture Associates IV, L.L.C.,
 	 
	 	
its General Partner 
 	 
	 	 	 
	 	By:	/s Alan E. Salzman
 	 
	 	Name:	Alan E. Salzman 	 
	 	Title:	Managing Member 	 
	 
	 	SOFINNOVA VENTURE PARTNERS VI,
L.P.,

as nominee for

SOFINNOVA VENTURE PARTNERS VI,
L.P.

SOFINNOVA VENTURE PARTNERS VI
GMBH CO. K.G.

SOFINNOVA VENTURE AFFILIATES VI,
L.P.

 	 
	 	By:	Sofinnova Management VI, LLC
 	 
	 	its General Partner 	 
	 	 	 
	 	By:	/s/ James Healy
 	 
	 	Name:	James Healy 	 
	 	Title:	Managing Member 	 
	 

SIGNATURE PAGE TO NOTE PURCHASE AGREEMENT OF

ANTHERA PHARMACEUTICALS, INC.

 

 

     IN WITNESS WHEREOF, the parties hereto have executed this Note Purchase Agreement as of the
date set forth in the first paragraph hereof.

	 	 	 	 	 
	 	PURCHASERS:

A. M. PAPPAS LIFE SCIENCE VENTURES III, L.P.

 	 
	 	By:	/s/ Ford S. Worthy
 	 
	 	Name:	Ford S. Worthy 	 
	 	Title:	Partner & CFO 	 
	 
	 	PV III CEO FUND, L.P.

 	 
	 	By:	/s/ Ford S. Worthy
 	 
	 	Name:	Ford S. Worthy 	 
	 	Title:	Partner & CFO 	 
	 

SIGNATURE PAGE TO NOTE PURCHASE AGREEMENT OF

ANTHERA PHARMACEUTICALS, INC.

 

 

     IN WITNESS WHEREOF, the parties hereto have executed this Note Purchase Agreement as of the
date set forth in the first paragraph hereof.

	 	 	 	 	 	 	 
	 	 	PURCHASER:	 	 
	 
	 	 	 	 	 	 
	 	 	CAXTON ADVANTAGE LIFE SCIENCES FUND, L.P.	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
  Caxton Advantage Venture Partners, L.P.,	 	 
	 	 	Its General Partner	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
Advantage Life Science Partners, LLC,	 	 
	 	 	its Managing Partner	 	 
	 
	 	 	 	 	 	 
	 

	 	By:	 	
 /s/ Rachel Leheny	 	 
	 

	 	 	 	 	 	 
	 

	 	Name: 
 Rachel Leheny	 	 
	 

	 	Title:
	 	Member	 	 
	 
	 	 	 	 	 	 
	 	 	HBM BIOCAPITAL	 	 
	 
	 	 	 	 	 	 
	 	 	HBM BioCapital (EUR) L.P.	 	 
	 

	 	By:
HBM BioCapital Ltd.	 	 
	 

	 	Its:
General Partner	 	 
	 
	 	 	 	 	 	 
	 	 	/s/ John Arnold	 	 
	 	 	 	 	 
	 

	 	By:
John Arnold	 	 
	 

	 	Its:
Chairman & Managing Director	 	 
	 
	 	 	 	 	 	 
	 	 	HBM BioCapital (USD) L.P.	 	 
	 

	 	By:
HBM BioCapital Ltd.	 	 
	 

	 	Its:
 General Partner	 	 
	 
	 	 	/s/ John Arnold	 	 
	 	 	 	 	 
	 

	 	By:
John Arnold	 	 
	 

	 	Its:
Chairman & Managing Director
	 	 

SIGNATURE PAGE TO NOTE PURCHASE AGREEMENT OF

ANTHERA PHARMACEUTICALS, INC.

 

 

SCHEDULE OF PURCHASERS

	 	     	 	 	 	     	 	 	 	     	 	 	 
	 	 	 	 	 	 	 	 	 	 	Warrant
	 	 	 	 	 	 	Warrant	 	Coverage
	 	 	 	 	 	 	Coverage	 	Amount on or
	 	 	Principal Balance of	 	Amount Prior to	 	after April 1,
	Name and Address of Purchaser	 	Initial Note	 	April 1, 2010*	 	2010*
	VantagePoint Venture Partners IV (Q), L.P.
	 	$	1,407,712.15	 	 	$	351,928.03	 	 	$	703,856.07	 
	1001 Bayhill Drive, Suite 300

San Bruno, CA 94066
	 	 	 	 	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 	 	 	 	 
	VantagePoint Venture Partners IV, L.P.
	 	$	140,926.59	 	 	$	35,231.65	 	 	$	70,463.30	 
	1001 Bayhill Drive, Suite 300

San Bruno, CA 94066
	 	 	 	 	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 	 	 	 	 
	VantagePoint Venture Partners IV Principals Fund, L.P.
	 	$	5,127.43	 	 	$	1,281.86	 	 	$	2,563.72	 
	1001 Bayhill Drive, Suite 300

San Bruno, CA 94066
	 	 	 	 	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 	 	 	 	 
	Sofinnova Venture Partners VI, L.P.
	 	$	1,003,365.50	 	 	$	250,841.37	 	 	$	501,682.75	 
	140 Geary Street, 10th Floor

San Francisco, CA 94108
	 	 	 	 	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 	 	 	 	 
	A. M. Pappas Life Science Ventures III, L.P.
	 	$	246,690.05	 	 	$	61,672.51	 	 	$	123,345.02	 
	P.O. Box 110287

Research Triangle Park, NC 27709
	 	 	 	 	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 	 	 	 	 
	PV III CEO Fund, L.P.
	 	$	15,328.06	 	 	$	3,832.02	 	 	$	7,664.03	 
	P.O. Box 110287

Research Triangle Park, NC 27709
	 	 	 	 	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 	 	 	 	 
	Caxton Advantage Life Sciences Fund, L.P.
	 	$	290,425.11	 	 	$	72,606.28	 	 	$	145,212.56	 
	500 Park Avenue

New York, NY 10022

Attention: Rachel Leheny

Email: rleheny@caxtonadvantage.com
	 	 	 	 	 	 	 	 	 	 	 	 

 

 

	 	     	 	 	 	     	 	 	 	     	 	 	 
	 	 	 	 	 	 	 	 	 	 	Warrant
	 	 	 	 	 	 	Warrant	 	Coverage
	 	 	 	 	 	 	Coverage	 	Amount on or
	 	 	Principal Balance of	 	Amount Prior to	 	after April 1,
	Name and Address of Purchaser	 	Initial Note	 	April 1, 2010*	 	2010*
	HBM BioCapital (EUR) L.P.
	 	$	246,861.34	 	 	$	61,715.34	 	 	$	123,430.67	 
	John Arnold

HBM BioCapital Ltd.

Centennial Towers, 3rd Floor

2454 West Bay Road

Grand Cayman

Cayman Islands
	 	 	 	 	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 	 	 	 	 
	HBM BioCapital (USD) L.P.
	 	$	43,563.77	 	 	$	10,890.94	 	 	$	21,781.88	 
	John Arnold

HBM BioCapital Ltd.

Centennial Towers, 3rd Floor

2454 West Bay Road

Grand Cayman

Cayman Islands
	 	 	 	 	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 	 	 
	Totals:
	 	$	3,400,000.00	 	 	$	850,000.00	 	 	$	1,700,000.00	 
	 	 	 	 	 	 	 	 	 	 

 

			
	*	 	Provided that (i) Warrant has been issued pursuant to Section 2.3(i) hereof, and (ii)
Exchange Note has not converted pursuant to Section 2.3(b) or (c) hereof.exv10w22

EXHIBIT 10.22

FORM OF INITIAL NOTE

THIS CONVERTIBLE PROMISSORY NOTE HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS
AMENDED. NO SALE OR DISPOSITION MAY BE EFFECTED EXCEPT IN COMPLIANCE WITH RULE 144 UNDER SAID ACT
OR AN EFFECTIVE REGISTRATION STATEMENT RELATED THERETO OR AN OPINION OF COUNSEL FOR THE HOLDER
SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED UNDER THE ACT OR RECEIPT OF A
NO-ACTION LETTER FROM THE SECURITIES AND EXCHANGE COMMISSION.

FORM OF SENIOR SECURED CONVERTIBLE PROMISSORY NOTE

			
	 	 	 
	$       
          
         
              
	 	December 11, 2009

Hayward, California

     For value received Anthera Pharmaceuticals, Inc., a Delaware corporation (“Payor” or
the “Company”) promises to pay to         
           
           
           or its assigns (“Holder”) the
principal sum of $               
           
           
    with simple interest on the outstanding principal amount at the rate
of Eight Percent (8%) per annum (the “Interest”). Interest shall commence with the date
hereof and shall continue on the outstanding principal until paid in full or converted. Interest
shall be computed on the basis of a year of 365 days for the actual number of days elapsed. Unless
otherwise defined herein, defined terms in this note (the “Note”) shall have the meanings
ascribed to them in that certain Note Purchase Agreement, dated as of December 11, 2009, by and
among the Company and the persons or entities listed on the Schedule of Purchasers attached thereto
(the “Purchase Agreement”).

     1. This Note is issued as part of a series of similar notes (collectively, the
“Notes”) to be issued pursuant to the terms of the Purchase Agreement to the persons or
entities listed on the Schedule of Purchasers attached thereto (collectively, the
“Holders”).

     2. Except as set forth herein and provided that this Note is not converted pursuant to Section
2.2 of the Purchase Agreement, all payments of interest and principal under this Note shall be made
in lawful money of the United States of America at such place as Holder may from time to time
designate in writing to the Company. All payments shall be applied first to accrued and unpaid
interest, and thereafter to the payment of principal. The Company may not prepay any principal
amount or interest on the Notes, in whole or in part.

     3. Unless earlier converted pursuant to Section 2.2 of the Purchase Agreement or exchanged
pursuant to Section 2.3 of the Purchase Agreement, the entire outstanding principal balance of this
Note plus all unpaid accrued interest thereon, if any, shall be due and payable in full immediately
upon the earlier of the following (the “Maturity Date”): (i) July 17, 2010 or (ii) any
Event of Default (as defined in Section 7 of the Purchase Agreement).

     4. This Note is secured pursuant to Section 2.4 of the Purchase Agreement. Reference is
hereby made to Section 2.4 of the Purchase Agreement for a complete description

1.

 

of the nature and extent of the security for this Note and the rights with respect to such
security of the holder of this Note.

     5. At any time prior to the Maturity Date, the principal balance and accrued and unpaid
interest of this Note shall automatically convert, in whole without any further action by
the Holders, upon the closing of the IPO into Conversion Shares in accordance with the terms
of Section 2.2(a) of the Purchase Agreement.

     6. Upon the conversion of a Note pursuant to Section 2.2 of the Purchase Agreement, in lieu of
any fractional shares to which the holder of such Note would otherwise be entitled, the Company
shall pay the Note’s holder cash equal to such fraction multiplied by the Initial Note Conversion
Price. Upon the conversion of this Note pursuant to Section 2.2 of the Purchase Agreement, Holder
shall surrender this Note, duly endorsed, at the principal offices of Company. At its expense,
Company will, as soon as practicable thereafter, issue and deliver to Holder (i) a certificate or
certificates for the number of shares to which Holder is entitled upon such conversion, together
with (ii) a check payable to Holder for any cash amounts described herein and (iii) any other
securities and property to which Holder is entitled upon such conversion under the terms of this
Note.

     7. In the event that the IPO has not been consummated on or before February 28, 2010 (the
“Exchange Date”), the principal balance and accrued and unpaid interest of this Note shall
be exchanged for an Exchange Note in accordance with the terms of Section 2.3(a) of the Purchase
Agreement. In the event of an exchange, Holder shall surrender this Note, duly endorsed, at the
principal offices of Company. At its expense, Company will, as soon as practicable thereafter,
issue and deliver to Holder (i) an Exchange Note reflecting the principal balance and accrued
interest through the Exchange Date and (ii) a Warrant issued in accordance with Section 2.3(i) of
the Purchase Agreement.

     8. Upon the earliest of (i) the full conversion of this Note pursuant to Section 2.2 of the
Purchase Agreement, (ii) exchange of this Note pursuant to Section 2.3(a) of the Purchase
Agreement, or (ii) the full payment of the amounts specified in this Note, the Company shall be
released from all of its obligations under this Note.

     9. If there shall be any Event of Default, the nature of which is described in Section 7.1 of
the Purchase Agreement, then, at the option and upon the declaration of the Required Note Holders
and upon written notice to the Company (which election and notice shall not be required in the case
of an Event of Default described in Section 7.1(b) or 7.1(c) of the Purchase Agreement), the entire
unpaid principal and accrued and unpaid interest on this Note shall be forthwith due and payable,
and the Holder hereof may, immediately and without expiration of any period of grace, enforce
payment of all amounts due and owing under this Note and exercise any and all other remedies
granted to it at law, in equity or otherwise.

     10. This Note shall be governed by the laws of the State of California, as applied to
agreements among California residents, made and to be performed entirely within the State of
California, without giving effect to conflicts of laws principles. Any dispute arising out of or
in connection with the transactions contemplated by this Note will be resolved solely by
confidential binding arbitration in San Francisco, California according to the then current

2.

 

commercial arbitration rules of JAMS. Each party shall bear its own attorneys’ fees, expert
witness fees, and costs connected to such arbitration.

     11. The amendment or waiver of any term of this Note, the resolution of any controversy or
claim arising out of or relating to this Note and the provision of notice shall be conducted
pursuant to the terms of the Purchase Agreement.

     12. This Note applies to, inures to the benefit of, and binds the successors and assigns of
the parties hereto. This Note may be transferred only (i) with the prior written consent of the
Company, (ii) in full compliance with applicable federal and state securities laws, (iii) to a
transferee or assignee whom or that has agreed in writing for the benefit of the Company to be
bound in all respects by the Purchase Agreement and by all restrictions on transfer as set forth in
the Rights Agreement and (iv) upon its surrender to the Company for registration of transfer, duly
endorsed, or accompanied by a duly executed written instrument of transfer in form satisfactory to
the Company. Thereupon, this Note shall be reissued to, and registered in the name of, the
transferee, or a new Note for like principal amount and interest shall be issued to, and registered
in the name of, the transferee. Interest and principal shall be paid solely to the registered
holder of this Note. Such payment shall constitute full discharge of the Company’s obligation to
pay such interest and principal. The Holder and any subsequent holder of this Note receives this
Note subject to the foregoing terms and conditions, and agrees to comply with the foregoing terms
and conditions for the benefit of the Company and any other Holders.

     13. In no event shall any officer or director of the Company be liable for any amounts due and
payable pursuant to this Note.

     14. Upon receipt of evidence reasonably satisfactory to the Company of the loss, theft,
destruction or mutilation of this Note and (in the case of loss, theft or destruction) upon
delivery of an indemnity agreement (with surety if reasonably required) in an amount reasonably
satisfactory to the Company, or (in the case of mutilation) upon surrender and cancellation of this
Note, the Company will issue, in lieu thereof, a new Note of like tenor.

[Remainder of Page Intentionally Left Blank]

3.

 

	 	 	 	 	 	 	 
	 	 	Anthera Pharmaceuticals, Inc.
	 
	 	 	 	 	 	 
	 

	 	By:	 	 	 	 
	 

	 	Name:
	 	 

Paul Truex
	 	 
	 

	 	Title:
	 	President and Chief Executive Officer	 	 

SIGNATURE PAGE TO

SENIOR SECURED CONVERTIBLE PROMISSORY NOTE

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