Document:

PROMISSORY NOTE
                                ===============

                                      FROM:
                                      ----

                                DERMISONICS, INC.
                                -----------------

                                      TO:
                                      --

                              BERRA HOLDINGS LTD.
                              -------------------

                                DERMISONICS, INC.
                                -----------------
Suite 1000, 789 West Pender Street, Vancouver, British Columbia, Canada, V6C 1H2
                                   ----------

<PAGE>
                                 PROMISSORY NOTE
                                 ===============

                             TO THE PROMISSORY NOTE
                             ----------------------
                      BETWEEN THE BORROWER AND THE LENDER
                      -----------------------------------
                        Principal Sum ofU.S.$552,514.00
                        -------------------------------

Principal:  U.S. $552,514.00.       Made at Vancouver, British Columbia, Canada.
            ----------------

Maturing:   APRIL 19, 2011.
            --------------

          THIS  PROMISSORY  NOTE is provided, dated and made effective as of the
          ----------------------
19th  day  of  April,  2007  (the  "Effective  Date").

FROM:
----

          DERMISONICS,  INC., a company incorporated under the laws of the State
          ------------------
          of  Nevada,  U.S.A., and having an address for notice and delivery and
          executive  offices  located  at  Suite  1000,  789 West Pender Street,
          Vancouver,  British  Columbia,  Canada,  V6C  1H2

          (the "Borrower");
                                                               OF THE FIRST PART
                                                               -----------------

TO:
--

          BERRA HOLDINGS LTD., having an address for notice and delivery located
          -------------------
          at  Chancery  Court,  Leeward  Highway,  Providencials, Turks & Caicos

          (the  "Lender");
                                                              OF THE SECOND PART
                                                              ------------------

          (the  Borrower  and  the  Lender  being  hereinafter  singularly  also
          referred to as a "Party" and collectively referred to as the "Parties"
          as  the  context  so  requires).

          FOR  VALUABLE  CONSIDERATION,  receipt whereof is hereby acknowledged,
          ----------------------------
the undersigned, Borrower, hereby owes and promises to pay to the Lender, or the
holder  of  this promissory note (the "Promissory Note"), in accordance with the
terms  and  conditions  referenced  herein,  the aggregate principal sum of five
hundred  and  fifty-two  thousand  five  hundred  and  fourteen  dollars  (U.S.
$552,514.00)  in  lawful  money of the United States (hereinafter referred to as
the "Principal Sum") together with simple interest accruing on the Principal Sum
and commencing on the above-referenced Effective Date of this Promissory Note at
the  rate  of  six percent (6.0%) per annum, and not in advance, both before and
after  default,  maturity  and  judgment  (herein the "Interest"); with any such
outstanding  Interest  to  be  payable in full to the Lender on repayment of the
Principal  Sum  in the manner as set forth immediately hereinbelow (and with the
totality of the within Principal Sum advance by the Lender to the Borrower being
the "Loan" hereunder); and with said Principal Sum and corresponding Loan hereby
representing  the full and complete value and the settlement of twenty-one point
one-seven

<PAGE>
                                      -2-

percent  (21.17%) of any and all indebtedness which was heretofore due and owing
by  the  Borrower  to  the  Lender  under  each  of  the  "Underlying Notes" (as
hereinafter  defined)  with  the  Borrower.

                              Repayment of the Loan
                              ---------------------

          The Principal Sum of this Loan, together with all outstanding Interest
accrued  thereon  as  specified  hereinabove,  is  hereby  irrevocably  and
unconditionally  due  and  payable by the Borrower to the order and direction of
the  Lender  in  Vancouver,  British  Columbia,  Canada,  at or before 5:00 p.m.
(Vancouver,  British  Columbia,  Canada,  time)  on  April  19, 2011 (the "Final
Principal  Sum  Payment  Date").

          The  Borrower  may  prepay and redeem any portion of the Principal Sum
portion  of  the Loan, and its then related Interest, in whole or in part at any
time  prior  to the Final Principal Sum Payment Date (the "Right of Redemption")
and  in  the manner as set forth immediately hereinbelow by providing the Lender
with  no  less  than  five  calendar days' prior written notice (the "Redemption
Notice")  of  its  Right  of Redemption intention to redeem and repay all or any
portion of the Principal Sum and any Interest accrued thereon which would be due
and  owing  by  the  Borrower  to  the Lender at the end of such five-day period
(collectively,  the  "Redemption  Amount") (such day at the end of such five-day
period  being the "Redemption Date" and, for clarity, such Redemption Date would
be the date to which such Principal Sum and Interest would be calculated and due
and  payable  to  the  Lender  at  the  close of business, in Vancouver, British
Columbia,  Canada,  on  such  Redemption  Date).

          In  order  to  provide  such  Redemption  Notice  the Borrower will be
required, at the date of its delivery to the Lender of the Redemption Notice, to
provide to the Lender's counsel, or to such other mutually agreeable holder (the
"Escrow  Holder"),  a  certified  cheque  or  bank draft representing the entire
Redemption  Amount and made payable to the Lender in funds of the United States,
or  funds  by way of wire transfer to such designation as may be directed by the
Lender in its sole and absolute discretion, in the amount of any such Redemption
Amount.  Thereupon,  and should the proposed Redemption Amount in fact represent
all of the Principal Sum and any Interest accrued thereon which would be due and
owing  by  the  Borrower  to  the Lender under this Promissory Note and the Loan
Agreement at the Redemption Date, then the Lender will be required to provide to
the  Escrow  Holder, and as soon as reasonably possible after its receipt of the
Redemption  Notice,  all  such  registerable  discharges  as may be necessary to
relieve  the  Borrower  of  any  obligation  to  the  Lender  under each of this
Promissory  Note  (collectively,  the "Discharges").  On the second business day
subsequent  to  the  Redemption  Date  the  Escrow  Holder, if applicable, shall
deliver to the Lender the Redemption Amount and, only if also applicable, to the
Borrower  the  Discharges,  and,  unless  otherwise  directed  in writing by the
Parties  prior  thereto,  to  the  Parties'  respective addresses for notice and
delivery  as  set  forth  on  the  front  page  of  this  Promissory  Note.

                   Background of the Loan and entire agreement
                   -------------------------------------------

          The  Parties  hereby  acknowledge and agree that the subject Principal
Sum  was  the  subject of each of those certain and previous "Promissory Note"s,
dated  for reference January 26, 2005, February 14, 2005, March 4, 2005, May 13,
2005,  June  6, 2005, June 9, 2005, June 23, 2005, July 15, 2005, July 27, 2005,
August  18,  2005, August 30, 2005, September 28, 2005, October 6, 2005, October
14,  2005, November 16, 2005, December 5, 2005 and March 17, 2006, respectively,
and  "Convertible  Promissory  Note"s,  dated  for reference August 29, 2005 and
December  9,  2005,  respectively  (collectively,  the  "Underlying  Notes"), as
previously  provided  by  the  Borrower  to  the  Lender and its recent assignee
(collectively,  the  "Underlying Notes"), as previously provided by the Borrower
to  the  Lender.

<PAGE>
                                      -3-

          The  Parties  hereby also acknowledge and agree that, in consideration
of the within issuance of this Promissory Note by the Borrower to the Lender for
the  full  and  complete  value and the settlement of twenty-one point one-seven
percent (21.17%) of each of the underlying loans under the Underlying Notes, the
within  Promissory  Note,  and  the  Principal Sum Loan and Interest represented
hereby,  now constitutes the entire agreement to date between the Parties hereto
and  respecting  the  within  Loan  and  supersedes  every  previous  agreement,
expectation,  negotiation,  representation  or  understanding,  whether  oral or
written,  express  or  implied, statutory or otherwise, between the Parties with
respect  to  the  subject  matter of this Promissory Note and including, without
limitation,  the  terms  and  conditions  of  each  of  the  Underlying  Notes.

                               General provisions
                               ------------------

          The  holder  of  this  Promissory  Note  may, from time to time, grant
written  indulgences with respect to certain payment amounts or periods but such
indulgences  will  not  in  any way affect the undersigned's liability upon this
Promissory  Note  nor  will  such  indulgences  vary  any  other  term  to which
indulgence has not specifically been granted.  No indulgence will be enforceable
against  the  holder  unless  granted  in  writing.

          The  undersigned hereby waives demand, presentment for payment, notice
of  non-payment  and  protest.

          If  any  provision  of  this  Promissory  Note  is held to be invalid,
illegal  or  unenforceable,  then  such  will not affect or impair the validity,
legality  or  enforceability  of  the  remaining  provisions.

          WITNESS  the  hands  of  the authorized representatives of each of the
          -------
undersigned  Parties  given  under  seal  as  of  the  Effective Date determined
hereinabove.

The  COMMON  SEAL  of                              )
DERMISONICS, INC.,                                 )
-----------------
the  Borrower  herein,                             )
was  hereunto  affixed  in  the  presence  of:     )                    (C/S)
                                                   )
                                                   )
---------------------------------------------------)
Authorized  Signatory                              )

The  COMMON  SEAL  of                              )
BERRA HOLDINGS LTD.,                               )
-------------------
the  Lender  herein,                               )
was  hereunto  affixed  in  the  presence  of:     )                    (C/S)
                                                   )
                                                   )
---------------------------------------------------)
Authorized  Signatory                              )
                                   __________PROMISSORY NOTE
                                 ---------------

                                      FROM:
                                      ----

                                DERMISONICS, INC.
                                -----------------

                                       TO:
                                       --

                             STAPLES MANAGEMENT INC.
                             -----------------------

                                DERMISONICS, INC.
                                -----------------
Suite 1000, 789 West Pender Street, Vancouver, British Columbia, Canada, V6C 1H2
                                   ----------

<PAGE>
                                 PROMISSORY NOTE
                                 ===============

                             TO THE PROMISSORY NOTE
                             ----------------------
                       BETWEEN THE BORROWER AND THE LENDER
                       -----------------------------------
                        Principal Sum ofU.S. $500,000.00
                        --------------------------------

Principal:  U.S. $500,000.00.       Made at Vancouver, British Columbia, Canada.
            ----------------

Maturing:   APRIL 19, 2011.
            --------------

          THIS  PROMISSORY  NOTE is provided, dated and made effective as of the
          ----------------------
19th  day  of  April,  2007  (the  "Effective  Date").

FROM:
----

          DERMISONICS,  INC., a company incorporated under the laws of the State
          ------------------
          of  Nevada,  U.S.A., and having an address for notice and delivery and
          executive  offices  located  at  Suite  1000,  789 West Pender Street,
          Vancouver,  British  Columbia,  Canada,  V6C  1H2

          (the "Borrower");
                                                               OF THE FIRST PART
                                                               -----------------

TO:
--

          STAPLES  MANAGEMENT  INC.,  having  an address for notice and delivery
          -------------------------
          located  at  P.O.  Box  WW-15419,  Nassau,  Bahamas

          (the  "Lender");
                                                              OF THE SECOND PART
                                                              ------------------

          (the  Borrower  and  the  Lender  being  hereinafter  singularly  also
          referred to as a "Party" and collectively referred to as the "Parties"
          as  the  context  so  requires).

          FOR  VALUABLE  CONSIDERATION,  receipt whereof is hereby acknowledged,
          ----------------------------
the undersigned, Borrower, hereby owes and promises to pay to the Lender, or the
holder  of  this promissory note (the "Promissory Note"), in accordance with the
terms  and  conditions  referenced  herein,  the aggregate principal sum of five
hundred thousand dollars (U.S. $500,000.00) in lawful money of the United States
(hereinafter  referred  to as the "Principal Sum") together with simple interest
accruing  on  the Principal Sum and commencing on the above-referenced Effective
Date  of  this  Promissory Note at the rate of six percent (6.0%) per annum, and
not in advance, both before and after default, maturity and judgment (herein the
"Interest");  with  any  such  outstanding Interest to be payable in full to the
Lender  on repayment of the Principal Sum in the manner as set forth immediately
hereinbelow  (and  with  the totality of the within Principal Sum advance by the
Lender  to the Borrower being the "Loan" hereunder); and with said Principal Sum
and  corresponding  Loan hereby representing the full and complete value and the
settlement  of  twenty-five  percent (25%) of any and all indebtedness which was

<PAGE>
heretofore  due  and  owing  by  the  Borrower  to  the Lender under each of the
"Underlying  Notes"  (as  hereinafter  defined)  with  the  Borrower.

                              Repayment of theLoan
                              --------------------

          The Principal Sum of this Loan, together with all outstanding Interest
accrued  thereon  as  specified  hereinabove,  is  hereby  irrevocably  and
unconditionally  due  and  payable by the Borrower to the order and direction of
the  Lender  in  Vancouver,  British  Columbia,  Canada,  at or before 5:00 p.m.
(Vancouver,  British  Columbia,  Canada,  time)  on  April  19, 2011 (the "Final
Principal  Sum  Payment  Date").

          The  Borrower  may  prepay and redeem any portion of the Principal Sum
portion  of  the Loan, and its then related Interest, in whole or in part at any
time  prior  to the Final Principal Sum Payment Date (the "Right of Redemption")
and  in  the manner as set forth immediately hereinbelow by providing the Lender
with  no  less  than  five  calendar days' prior written notice (the "Redemption
Notice")  of  its  Right  of Redemption intention to redeem and repay all or any
portion of the Principal Sum and any Interest accrued thereon which would be due
and  owing  by  the  Borrower  to  the Lender at the end of such five-day period
(collectively,  the  "Redemption  Amount") (such day at the end of such five-day
period  being the "Redemption Date" and, for clarity, such Redemption Date would
be the date to which such Principal Sum and Interest would be calculated and due
and  payable  to  the  Lender  at  the  close of business, in Vancouver, British
Columbia,  Canada,  on  such  Redemption  Date).

          In  order  to  provide  such  Redemption  Notice  the Borrower will be
required, at the date of its delivery to the Lender of the Redemption Notice, to
provide to the Lender's counsel, or to such other mutually agreeable holder (the
"Escrow  Holder"),  a  certified  cheque  or  bank draft representing the entire
Redemption  Amount and made payable to the Lender in funds of the United States,
or  funds  by way of wire transfer to such designation as may be directed by the
Lender in its sole and absolute discretion, in the amount of any such Redemption
Amount.  Thereupon,  and should the proposed Redemption Amount in fact represent
all of the Principal Sum and any Interest accrued thereon which would be due and
owing  by  the  Borrower  to  the Lender under this Promissory Note and the Loan
Agreement at the Redemption Date, then the Lender will be required to provide to
the  Escrow  Holder, and as soon as reasonably possible after its receipt of the
Redemption  Notice,  all  such  registerable  discharges  as may be necessary to
relieve  the  Borrower  of  any  obligation  to  the  Lender  under each of this
Promissory  Note  (collectively,  the "Discharges").  On the second business day
subsequent  to  the  Redemption  Date  the  Escrow  Holder, if applicable, shall
deliver to the Lender the Redemption Amount and, only if also applicable, to the
Borrower  the  Discharges,  and,  unless  otherwise  directed  in writing by the
Parties  prior  thereto,  to  the  Parties'  respective addresses for notice and
delivery  as  set  forth  on  the  front  page  of  this  Promissory  Note.

                   Background of the Loan and entire agreement
                   -------------------------------------------

          The  Parties  hereby  acknowledge and agree that the subject Principal
Sum  was  the  subject  of  each  of  those  certain  and  previous "Convertible
Promissory  Note"s,  dated  for  reference  July  14,  2006 and October 3, 2006,
respectively  (collectively,  the "Underlying Notes"), as previously provided by
the  Borrower  to  the  Lender.

          The  Parties  hereby also acknowledge and agree that, in consideration
of the within issuance of this Promissory Note by the Borrower to the Lender for
the  full  and complete value and the settlement of twenty-five percent (25%) of
each  of  the  underlying loans under the Underlying Notes and all related prior
accrued  interest,  the  within  Promissory Note, and the Principal Sum Loan and
Interest  represented  hereby,  now  constitutes  the  entire  agreement to date
between  the  Parties hereto and respecting the within Loan and supersedes every
previous

<PAGE>
agreement,  expectation,  negotiation,  representation or understanding, whether
oral or written, express or implied, statutory or otherwise, between the Parties
with  respect  to  the  subject  matter  of  this Promissory Note and including,
without  limitation,  the  terms and conditions of each of the Underlying Notes.

                               General provisions
                               ------------------

          The  holder  of  this  Promissory  Note  may, from time to time, grant
written  indulgences with respect to certain payment amounts or periods but such
indulgences  will  not  in  any way affect the undersigned's liability upon this
Promissory  Note  nor  will  such  indulgences  vary  any  other  term  to which
indulgence has not specifically been granted.  No indulgence will be enforceable
against  the  holder  unless  granted  in  writing.

          The  undersigned hereby waives demand, presentment for payment, notice
of  non-payment  and  protest.

          If  any  provision  of  this  Promissory  Note  is held to be invalid,
illegal  or  unenforceable,  then  such  will not affect or impair the validity,
legality  or  enforceability  of  the  remaining  provisions.

          WITNESS  the  hands  of  the authorized representatives of each of the
          -------
undersigned  Parties  given  under  seal  as  of  the  Effective Date determined
hereinabove.

The  COMMON  SEAL  of                              )
DERMISONICS, INC.,                                 )
-----------------
the  Borrower  herein,                             )
was  hereunto  affixed  in  the  presence  of:     )                    (C/S)
                                                   )
                                                   )
---------------------------------------------------)
Authorized  Signatory                              )

The  COMMON  SEAL  of                              )
STAPLES MANAGEMENT INC.,                           )
-----------------------
the  Lender  herein,                               )
was  hereunto  affixed  in  the  presence  of:     )                    (C/S)
                                                   )
                                                   )
---------------------------------------------------)
Authorized  Signatory                              )
                                   ----------

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