Document:

<PAGE>   1

                                                                   EXHIBIT 10.16

                  AMENDMENT NUMBER ONE TO EMPLOYMENT AGREEMENT

         This Amendment Number One is made and entered into this 6th day of
October, 2000 by and among ACCREDO HEALTH, INCORPORATED, a Delaware corporation
(the "Company") and KYLE J. CALLAHAN (the "Executive").

                                   WITNESSETH

         WHEREAS, the Company and Executive entered into an Employment Agreement
dated as of September 1, 1999; and

         WHEREAS, the parties now desire to make certain amendments to said
Employment Agreement as set forth below.

         NOW THEREFORE, for good and valuable consideration, the receipt and
adequacy of which is hereby acknowledged, the parties hereto agrees as follows:

         1.       Section 4.(a) of the Employment Agreement be and hereby is
                  amended to provide that effective September 1, 2000, the first
                  sentence thereof is deleted and the following sentence is
                  adopted in the place thereof:

                  As compensation for the performance by the Executive of the
                  services to be performed by the Executive hereunder during the
                  Employment Term, the Company shall pay the Executive a base
                  salary effective September 1, 2000 at the annual rate of One
                  Hundred Ninety-Five Thousand Six Hundred Thirty-Two and 00/100
                  ($195,632.00) Dollars (said amount being hereinafter referred
                  to as "Salary").

         2.       In order to reflect fiscal year 2001 bonus targets, Exhibit A
                  attached to and made a part of the Employment Agreement be and
                  hereby is amended by deleting Exhibit A in its present form
                  and substituting in the place thereof Exhibit A as attached to
                  this Amendment Number One.

         3.       Except as amended herein, all terms and conditions of the
                  Employment Agreement shall remaining in full force and effect.

         IN WITNESS WHEREOF, the Company and the Executive have duly executed
and delivered this Agreement as of the date and year first above written.

                                     ACCREDO HEALTH, INCORPORATED

                                     By:        /s/  Thomas W. Bell, Jr.
                                        ---------------------------------------

                                     Title:  Senior Vice President, Secretary
                                           ------------------------------------

                                           /s/   Kyle J. Callahan
                                     ------------------------------------------
                                     KYLE J. CALLAHAN

<PAGE>   2

                                    EXHIBIT A
                         FISCAL YEAR 2001 BONUS TARGETS

TARGET Diluted EPS set by Board of Directors

<TABLE>
<CAPTION>
-------------------------------------------------------------------------------
                                           MAXIMUM INCENTIVE
          DILUTED EPS                      BONUS POTENTIAL(1)
-------------------------------------------------------------------------------
                                     75%                       100%
-------------------------------------------------------------------------------
    <S>                           <C>                         <C>
    TARGET less $.05                7.5%                        10%
-------------------------------------------------------------------------------
    TARGET less $.04               15.0%                        20%
-------------------------------------------------------------------------------
    TARGET less $.03               30.0%                        40%
-------------------------------------------------------------------------------
    TARGET less $.02               45.0%                        60%
-------------------------------------------------------------------------------
    TARGET less $.01               52.5%                        70%
-------------------------------------------------------------------------------
    TARGET                         60.0%                        80%
-------------------------------------------------------------------------------
    TARGET plus $.01               67.5%                        90%
-------------------------------------------------------------------------------
    TARGET plus $.02               75.0%                       100%
-------------------------------------------------------------------------------
</TABLE>

------------------

(1)      The 75% column applies to Joel Kimbrough, Thomas W. Bell, Jr., Kyle
         Callahan and John R. Grow.

         The 100% column applies to David D. Stevens.<PAGE>   1
                                                                   EXHIBIT 10.17

                  AMENDMENT NUMBER ONE TO EMPLOYMENT AGREEMENT

         This Amendment Number One is made and entered into this 6th day of
October, 2000 by and among ACCREDO HEALTH, INCORPORATED, a Delaware corporation
(the "Company") and THOMAS W. BELL, JR. (the "Executive").

                                   WITNESSETH

         WHEREAS, the Company and Executive entered into an Employment Agreement
dated as of September 1, 1999; and

         WHEREAS, the parties now desire to make certain amendments to said
Employment Agreement as set forth below.

         NOW THEREFORE, for good and valuable consideration, the receipt and
adequacy of which is hereby acknowledged, the parties hereto agrees as follows:

         1.       Section 4.(a) of the Employment Agreement be and hereby is
                  amended to provide that effective September 1, 2000, the first
                  sentence thereof is deleted and the following sentence is
                  adopted in the place thereof:

                  As compensation for the performance by the Executive of the
                  services to be performed by the Executive hereunder during the
                  Employment Term, the Company shall pay the Executive a base
                  salary effective September 1, 2000 at the annual rate of One
                  Hundred Ninety-One Thousand Four Hundred Forty-Four and 00/100
                  ($191,444.00) Dollars (said amount being hereinafter referred
                  to as "Salary").

         2.       In order to reflect fiscal year 2001 bonus targets, Exhibit A
                  attached to and made a part of the Employment Agreement be and
                  hereby is amended by deleting Exhibit A in its present form
                  and substituting in the place thereof Exhibit A as attached to
                  this Amendment Number One.

         3.       Except as amended herein, all terms and conditions of the
                  Employment Agreement shall remaining in full force and effect.

         IN WITNESS WHEREOF, the Company and the Executive have duly executed
and delivered this Agreement as of the date and year first above written.

                                    ACCREDO HEALTH, INCORPORATED

                                    By:     /s/  Joel R. Kimbrough
                                       --------------------------------------

                                    Title:   Chief Financial Officer
                                          -----------------------------------

                                            /s/  Thomas W. Bell, Jr.
                                    -----------------------------------------
                                    THOMAS W. BELL, JR.

<PAGE>   2

                                    EXHIBIT A
                         FISCAL YEAR 2001 BONUS TARGETS

TARGET Diluted EPS set by Board of Directors

<TABLE>
<CAPTION>
-------------------------------------------------------------------------------
                                           MAXIMUM INCENTIVE
          DILUTED EPS                      BONUS POTENTIAL(1)
-------------------------------------------------------------------------------
                                     75%                       100%
-------------------------------------------------------------------------------
    <S>                           <C>                         <C>
    TARGET less $.05                7.5%                        10%
-------------------------------------------------------------------------------
    TARGET less $.04               15.0%                        20%
-------------------------------------------------------------------------------
    TARGET less $.03               30.0%                        40%
-------------------------------------------------------------------------------
    TARGET less $.02               45.0%                        60%
-------------------------------------------------------------------------------
    TARGET less $.01               52.5%                        70%
-------------------------------------------------------------------------------
    TARGET                         60.0%                        80%
-------------------------------------------------------------------------------
    TARGET plus $.01               67.5%                        90%
-------------------------------------------------------------------------------
    TARGET plus $.02               75.0%                       100%
-------------------------------------------------------------------------------
</TABLE>

------------------
(1)      The 75% column applies to Joel Kimbrough, Thomas W. Bell, Jr., Kyle
         Callahan and John R. Grow.

         The 100% column applies to David D. Stevens.<PAGE>   1
                                                                    EXHIBIT 10.1

                       SIXTH AMENDMENT TO CREDIT AGREEMENT

         ENTERED into by and between CHILDREN'S COMPREHENSIVE SERVICES, INC., a
Tennessee corporation (the "Borrower"), SUNTRUST BANK, successor-in-interest to
SunTrust Bank, Nashville, N.A., in its capacity as agent for Lenders ("Agent"),
SUNTRUST BANK, successor-in-interest to SunTrust Bank, Nashville, N.A. ("STB"),
and AMSOUTH BANK, successor-in-interest to First American National Bank
("AMSOUTH") (STB and AMSOUTH shall be referred to herein as "Lenders'), as of
this 13 day of February, 2001.

                                    RECITALS

         1. The Borrower, the Lenders, and the Agent entered into a Credit
Agreement dated as of December 1, 1998, as amended by a First Amendment to
Credit Agreement dated as of December 31, 1998, a Second Amendment to Credit
Agreement dated as of April 20, 1999, a Third Amendment to Credit Agreement
dated as of September 27, 1999, a Fourth Amendment to Credit Agreement dated as
of January 15, 2000, and a Fifth Amendment to Credit Agreement dated as of April
21, 2000 (herein collectively the "Credit Agreement").

         2. The Borrower, the Lenders, and the Agent desire to amend the Credit
Agreement as set forth herein.

         NOW, THEREFORE, in consideration of the premises and for other good and
valuable consideration, the receipt and adequacy of which is hereby
acknowledged, the parties hereto agree as follows:

         1. The definition of "Applicable Margin" as used in Section 1.1 of the
Credit Agreement shall be amended and restated as follows:

            "Applicable Margin" shall mean the number of basis points per
         annum determined in accordance with the table set forth below based on
         the fiscal quarter-end ratio of Borrower's Funded Debt to EBITDA:

<TABLE>
<CAPTION>
----------------------------------------------------------------------------------------------------------------------
                               TIER I                 TIER II                 TIER III                TIER IV

Ratio of Funded              <1.5 to 1.0         > 1.5 to 1.0 and       > 2.00 to 1.0 and         > 2.5 to 1.0
Debt to EBITDA                                   -                      -                         -
                                                   < 2.00 to 1.0           < 2.5 to 1.0
----------------------------------------------------------------------------------------------------------------------
<S>                      <C>                    <C>                      <C>                     <C>
Applicable Margin for    30 basis points per    50 basis points per      50 basis points per     75 basis points per
Facility Fee                    annum                 annum                    annum                    annum
----------------------------------------------------------------------------------------------------------------------
Applicable Margin for   175 basis points per   217.5 basis points per   265 basis points per     325 basis points per
Eurodollar Advances             annum                  annum                   annum                    annum
----------------------------------------------------------------------------------------------------------------------
Applicable Margin for    75 basis points per   117.5 basis points per   165 basis points per     225 basis points per
Base Rate Advances              annum                  annum                   annum                    annum
----------------------------------------------------------------------------------------------------------------------
</TABLE>

<PAGE>   2

         2. The definition of "Maturity Date" as used in Section 1.1 of the
Credit Agreement shall be amended and restated as follows:

            "Maturity Date" shall mean: (a) for the Revolving Loans, the earlier
         of (i) April 30, 2002, and (ii) the date on which all amounts
         outstanding under this Agreement have been declared or have
         automatically become due and payable pursuant to the provisions of
         Article 8, and (b) for the Term Loans, the earlier of (i) October 31,
         2005, and (ii) the date on which all amounts outstanding under this
         Agreement have been declared or have automatically become due and
         payable pursuant to the provisions of Article 8.

         3. Section 7.1(b) of the Credit Agreement is amended and restated as
follows:

            (b) Fixed Charge Coverage Ratio. As calculated for the most recently
         concluded fiscal quarter and the immediately three (3) preceding fiscal
         quarters, suffer or permit as of the last day of any fiscal quarter,
         the ratio of (A) the sum of (1) Consolidated EBIT, plus (2)
         Consolidated Rental Expense, minus (3) dividends paid, to (B) the sum
         of (1) Consolidated Interest Expense, plus (2) Consolidated Rental
         Expense, plus (3) principal payments paid on the Term Loans to be less
         than 2.0 to 1.0.

         4. The Revolving Credit Commitments as set forth in the Credit
Agreement are amended and restated as follows:

            a. SunTrust Bank - $12,500,000; and

            b. AmSouth Bank - $7,500,000.

         5. The Credit Agreement is not amended in any other respect.

         6. The Borrower reaffirms its obligations as set forth in the Credit
Agreement, as amended hereby, and the Borrower agrees that its obligations
thereunder are valid and binding, enforceable in accordance with its terms,
subject to no defense, counterclaim, or objection.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

                            [SIGNATURES ON NEXT PAGE]

                                       2
<PAGE>   3

         ENTERED INTO as of the date first above written.

                                    BORROWER:

                                    CHILDREN'S COMPREHENSIVE
                                    SERVICES, INC.

                                    By: /s/ Donald B. Whitfield
                                        ----------------------------------------
                                    Title: Vice President Finance/CFO
                                           -------------------------------------

                                    AGENT:

                                    SUNTRUST BANK, Agent

                                    By: /s/ Stephen C. Baird
                                        ----------------------------------------
                                    Title: Corporate Banking Officer
                                           -------------------------------------

                                    LENDERS:

                                    SUNTRUST BANK

                                    By: /s/ Stephen C. Baird
                                        ----------------------------------------
                                    Title: Corporate Banking Officer
                                           -------------------------------------

                                    AMSOUTH BANK

                                    By: /s/ Allison H. Jones
                                        ----------------------------------------
                                    Title: Vice President
                                           -------------------------------------

                                       3

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