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                                                                   Exhibit 10.92
                                            ***TEXT OMITTED AND FILED SEPARATELY
                                                CONFIDENTIAL TREATMENT REQUESTED
                                          UNDER 17 C.F.R. SECTIONS 200.80(b)(4),
                                                            200.83 AND 240.24b-2

                         NON-EXCLUSIVE LICENSE AGREEMENT

       THIS NON-EXCLUSIVE LICENSE AGREEMENT (the "Agreement") is entered into as
of August 17, 2001 (the "Effective Date"), by and between EPIMMUNE INC., a
corporation organized under the laws of the State of Delaware, having offices at
5820 Nancy Ridge Drive, San Diego, California 92121 ("Epimmune"), and BIOSITE
INCORPORATED, a company organized under the laws of the State of Delaware,
having offices at 11030 Roselle Street, Suite D, San Diego, California 92121
("Biosite"). Epimmune and Biosite may each be referred to herein individually as
a "Party" and collectively as the "Parties."

       WHEREAS, Epimmune has developed and owns the PADRE(R) (defined below)
technology; and

       WHEREAS, Biosite wishes to obtain, and Epimmune is willing to grant, a
non-exclusive license under the Licensed Technology (as defined below) on the
terms and subject to the conditions set forth herein.

       NOW, THEREFORE, in consideration of the mutual covenants and promises
hereinafter set forth, the Parties hereby agree as follows:

                                    ARTICLE 1

                                   DEFINITIONS

       1.1 "AFFILIATE" shall mean any corporation or other entity which
controls, is controlled by, or is under common control with, another corporation
or entity. A corporation or other entity shall be regarded as in control of
another corporation or entity if it owns or directly or indirectly controls more
than fifty percent (50%) of the voting securities or other ownership interest of
the other corporation or entity.

       1.2 "CONFIDENTIAL INFORMATION" shall mean any confidential or proprietary
information of a Party or its Affiliate, including information related to the
Licensed Technology, and any other information relating to any compound,
research project, work in process, future development, scientific, engineering,
manufacturing, marketing, business plan, financial or personnel matter relating
to such Party or its Affiliate, its present or future products, sales,
suppliers, customers, employees, investors or business, whether in oral,
written, graphic or electronic form, including, without limitation, trade
secrets, processes, formulae, data and know-how, improvements, inventions,
techniques, biological materials, marketing plans, strategies, forecasts and
customer and contact lists; in each case which is marked, identified as or
otherwise acknowledged to be confidential at the time of disclosure to the other
party.

       1.3 "CONTROL" shall mean possession of the ability to grant a license or
sublicense as provided for herein without violating the terms of any agreement
or other arrangement with any Third Party.

       1.4 "FIELD" shall mean [...***...].

       1.5 "KNOW-HOW" shall mean all inventions, discoveries, materials,
technology, trade secrets, data, processes, techniques, procedures,
compositions, devices, methods, formulas, protocols and information, or other
know-how, whether or not patentable, which (i) are Controlled by Epimmune as of
the Effective Date or during the Term, (ii) are not generally known, and (iii)
relate to PADRE(R), its manufacture or use, or PADRE(R) Improvements (defined in
Section 5.1(b)).

       1.6 "LICENSED TECHNOLOGY" shall mean, to the extent necessary or useful
for research, development, manufacture, use, sale or import of Products, all
Patent Rights and Know-How.

       1.7 "PADRE(R)" shall mean a peptide capable of binding antigen binding
sites on major histocompatibility complex (MHC) molecules encoded by
substantially all alleles of a DR locus, including, without

                                               *CONFIDENTIAL TREATMENT REQUESTED
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limitation, a composition comprising a peptide recited in the claims of United
States Patent Application Serial No. 08/121,101 filed September 14, 1993 and any
patent applications, U.S., international and foreign, that derive priority from
such patent application, such as continuing applications (including, without
limitation, any continuations, continuations-in-part or divisionals thereof) and
any patents issuing therefrom. Such peptides are also referred to as pan DR
binding peptides and include, without limitation, AKXVAAWTLKAAA (using the
single letter designation for amino acids), wherein X is cyclohexylalanine or
phenylalanine, and other peptides claimed and/or disclosed in the patent
applications described in this Section 1.7.

       1.8 "PADRE(R) CONSTRUCT" shall mean any biological construct comprised of
PADRE(R) fused or linked to another molecule or complex of molecules or DNA
encoding PADRE(R) fused to DNA encoding a polypeptide.

       1.9 "PATENT RIGHTS" shall mean all patents and patent applications,
including provisional applications, and all patents issuing thereon (including
utility, model and design patents and certificates of invention), together with
all reissue patents, patents of addition, divisions, renewals, continuations,
continuations-in-part, continued prosecution applications, requests for
continued examination, substitutions, additions, extensions or restorations (by
existing or future extension or restoration mechanisms, including, without
limitation, supplemental protection certificates), registrations, confirmations,
reexaminations and foreign counterparts of any of the foregoing, which (i) are
Controlled by Epimmune as of the Effective Date or during the Term, and (ii)
relate to PADRE(R) or PADRE(R) Improvements (defined in Section 5.1(b))
including, without limitation, the patents and patent applications listed on
Appendix I.

       1.10 "PRODUCT" shall mean any product, other than a vaccine, comprising
or derived directly or indirectly from an antibody or a fragment thereof that is
induced by immunization of animals with an antigen formulated with or comprised
of a PADRE(R) Construct.

       1.11 "SUBLICENSEE" shall mean any Affiliate of Biosite or any Third Party
to which Biosite has granted a sublicense pursuant to Section 2.2.

       1.12 "THIRD PARTY" shall mean any entity other than Epimmune or Biosite
or an Affiliate of Epimmune or Biosite.

                                    ARTICLE 2

                                GRANT OF LICENSE

       2.1 LICENSE. Subject to the terms and conditions of this Agreement,
Epimmune hereby grants to Biosite a non-exclusive, non-transferable (except in
accordance with Section 8.1), irrevocable (except in accordance with Section
7.2), [...***...], worldwide license, with the right to grant sublicenses in
accordance with Section 2.2, under the Licensed Technology: (i) to make, have
made and use PADRE(R) as part of a PADRE(R) Construct solely for the purpose of
generating antibodies in connection with the research and development of
Products for use in the Field, and (ii) to make, have made, use, offer for sale,
sell, have sold and import Products for use in the Field. Nothing herein shall
be construed as granting Biosite the right to use, sell, have sold, make, have
made, import or otherwise transfer or commercialize: (i) PADRE(R) as a component
of any pharmaceutical product, or (ii) any therapeutic vaccines or prophylactic
vaccines using PADRE(R).

       2.2 SUBLICENSING RIGHTS.

              (a) Biosite shall have the right to grant sublicenses under the
rights granted in Section 2.1(i) solely to its Affiliates. Biosite may not
sublicense such rights to any Third Party, provided, however, that Biosite may
permit collaborators of Biosite to prepare immunogens and/or conduct
immunizations using PADRE(R) Constructs, and to transfer such immunogens or
immunized animals or tissues or RNA extracted therefrom to Biosite for use to
generate antibodies in connection with the research and development off Products
for use in the Field. Biosite shall have the right to grant sublicenses under
the rights granted to it under Section 2.1(ii) to its Affiliates or to any Third
Party to which Biosite licenses rights to or transfers one or more Products,
subject to the

                                               *CONFIDENTIAL TREATMENT REQUESTED

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terms and conditions of this Agreement. Biosite shall provide written notice to
Epimmune of any such sublicense within thirty (30) days after execution thereof.

              (b) Any sublicense granted by Biosite under this Agreement shall
be subject and subordinate to, and consistent with, the terms and conditions of
this Agreement. Biosite shall notify any Sublicensee of all rights and
obligations of Biosite under this Agreement applicable to such Sublicensee,
including, without limitation, Article 4.

              (c) If this Agreement terminates for any reason, any Sublicensee
shall automatically become a direct licensee of Epimmune with respect to the
rights originally sublicensed to it by Biosite, provided such Sublicensee did
not cause the termination of this Agreement and such Sublicensee agrees to
comply with all of the terms of this Agreement and assume the responsibilities
of Biosite hereunder, including, without limitation, the making of payments and
reports directly to Epimmune and the remedying of any breach by Biosite of this
Agreement, to the extent reasonably practicable.

       2.3 DISCLOSURE OF LICENSED TECHNOLOGY. Within [...***...], Epimmune shall
disclose and transfer to Biosite all Know-How in existence as of [...***...],
and the practice thereof in accordance with the license granted under Section
2.1.

       2.4 [...***...]

                                    ARTICLE 3

                               PAYMENT OBLIGATIONS

       3.1 LICENSE FEE. In consideration for the license granted hereunder,
Biosite agrees to pay to Epimmune [...***...].

       3.2 LATE PAYMENT. In the event that any payment of the license fee under
Section 3.1, or part thereof, is not made when due, the payment, or part
thereof, shall accrue interest from the date due at the rate of [...***...];
provided, however, that in no event shall such rate exceed the maximum legal
annual interest rate. The payment of such interest shall not limit Epimmune from
exercising any other rights it may have as a consequence of the lateness of such
payment.

                                    ARTICLE 4

                                 CONFIDENTIALITY

       4.1 CONFIDENTIALITY. During the Term and for a period of [...***...]
thereafter, Epimmune will maintain in confidence all Confidential Information
disclosed by Biosite or its Affiliates hereunder, and Biosite will maintain in
confidence all Confidential Information disclosed by Epimmune or its Affiliates
hereunder. Neither Party will use, disclose or grant use of such Confidential
Information except as expressly authorized by this Agreement. To the extent that
disclosure is authorized by this Agreement, the disclosing Party will obtain
prior agreement from its employees, agents, consultants and Sublicensees to whom
disclosure is to be made to hold in confidence and not make use of such
information for any purpose other than those permitted by this Agreement. Each
Party will use at least the same standard of care as it uses to protect its own
Confidential Information to obligate such employees, agents, consultants and
Sublicensees not to disclose or make any unauthorized use of such Confidential
Information. Each Party will promptly notify the other upon discovery of any
unauthorized use or disclosure of the Confidential Information.

       4.2 EXCEPTIONS. The obligations of confidentiality contained in Section
4.1 will not apply to the extent that it can be established by the receiving
Party by competent written proof that such Confidential Information:

              (a) is now, or hereafter becomes, through no act or failure to act
on the part of the receiving

                                               *CONFIDENTIAL TREATMENT REQUESTED

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Party, generally known or available to the public;

              (b) is known by the receiving Party at the time of receiving such
information or is developed by receiving Party thereafter in the course of work
entirely independent of and without reference to any Confidential Information
disclosed by the disclosing Party, in each case, as evidenced by its records; or

              (c) is hereafter furnished to the receiving Party by a Third
Party, as a matter of right and without restriction on disclosure, which Third
Party is not under an obligation of confidentiality to the disclosing Party.

       4.3 AUTHORIZED DISCLOSURE. Each Party may disclose the Confidential
Information of the other Party to the extent such disclosure (a) is the subject
of a written permission to disclose provided by such other Party, or (b) is
reasonably necessary in filing or prosecuting patent applications, prosecuting
or defending litigation or complying with applicable governmental regulations,
including, but not limited to the conduct by Biosite of any clinical trials or
registration of any Product, provided that if such Party is required to make any
such disclosure of such Confidential Information it will give reasonable advance
notice to the other Party of such disclosure requirement with an opportunity to
review and revise the proposed disclosure and, except to the extent
inappropriate in the case of patent applications, will use reasonable efforts to
secure confidential treatment of such information required to be disclosed.

       4.4 PRESS RELEASE. Except as otherwise provided in Section 4.3 above,
neither party shall disclose any terms or conditions of this Agreement to any
Third Party without the prior consent of the other party. Notwithstanding the
foregoing, the Parties agree that a press release announcing the matters covered
by this Agreement in substantially the form attached hereto as Appendix II will
be issued, and either Party may publicize the existence and general subject
matter of this Agreement consistent with such press release without the other
Party's approval.

                                    ARTICLE 5

                          INTELLECTUAL PROPERTY RIGHTS

       5.1 OWNERSHIP OF INVENTIONS.

              (a) Inventorship of inventions shall be determined in accordance
with the rules of inventorship under United States patent law.

              (b) Epimmune shall have sole ownership of all inventions,
discoveries, developments and improvements made, conceived or reduced to
practice in the course of activities conducted under this Agreement solely
pertaining to PADRE(R) or its manufacture or use, regardless of whether made
solely by employees and agents of Epimmune, solely by employees or agents of
Biosite or jointly by employees or agents of Epimmune and employees or agents of
Biosite ("PADRE(R) Improvements"), and all patent applications, patents and
other intellectual property rights directed to such PADRE(R) Improvements.
Biosite hereby irrevocably assigns to Epimmune all right, title and interest in
and to any such PADRE(R) Improvements and all patent applications, patents and
all other intellectual property rights directed to such PADRE(R) Improvements.
In the event that Biosite is legally unable to assign such rights to Epimmune,
then Biosite agrees either to waive the enforcement of such rights against
Epimmune and any sublicensees and assignees, or to grant Epimmune an exclusive,
irrevocable, perpetual, worldwide, fully-paid license, with right to sublicense
through multiple tiers of sublicense, to such rights.

              (c) Except as provided in Section 5.1(b), ownership of all
inventions, discoveries, developments and improvements conceived or reduced to
practice in the course of activities conducted under this Agreement, and all
patent applications, patents and other intellectual property rights directed to
such inventions, discoveries, developments and improvements, shall be determined
in accordance with inventorship (i.e., a Party shall solely own all such
inventions, discoveries, developments and improvements made solely by its
employees or agents, and the Parties shall jointly own all such inventions,
discoveries, developments and improvements made jointly by their respective
employees or agents). Each party shall have the right, subject to the provisions
of this

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Agreement, to freely exploit, transfer, license or encumber its rights in any
jointly owned invention, discovery, development or improvement (or the patent
and other intellectual property rights therein) without the consent of, or
compensation or accounting to, the other party.

       5.2 FILING, PROSECUTION AND MAINTENANCE OF PATENTS AND PATENT
APPLICATIONS. Epimmune shall have the sole right to control the filing,
prosecution and maintenance of, all patent applications and patents included in
the Patent Rights, at Epimmune's expense. Epimmune shall keep Biosite advised of
the status of the actual and prospective patent filings included in the Patent
Rights, including, without limitation, the filing of any patent application or
grant of any patent, and Epimmune shall allow Biosite to provide input related
to any patent application included in the Patent Rights that is relevant to any
Product. As between the Parties, the Party that owns any patent applications and
patents arising in the course of activities conducted under this Agreement shall
have the sole right, at its own expense, to control, and the other Party shall
reasonably cooperate with such Party to facilitate, the filing, prosecution and
maintenance of such patent applications and patents. With respect to joint
patent applications or patents arising in the course of activities conducted
under this Agreement, if any, the Parties will share equally the control of and
expenses associated with the filing, prosecution and maintenance of such joint
patent applications or patents, unless a party disclaims ownership of any such
joint patent application or patent, in which case such party shall assign to the
other party all its right, title and interest in and to any such joint patent
application or patent, and such other party shall have the sole right to
control, file, prosecute and maintain any such joint patent application or
patent, in its sole discretion and at its sole expense.

       5.3 INFRINGEMENT ACTIONS.

              (a) Epimmune shall have the sole right, at its discretion, to
prosecute any and all infringements of any Patent Rights, whether inside or
outside the Field.

              (b) Biosite shall have the first right, in its sole discretion to
control at its own expense the defense of all charges of infringement by any
Third Party arising as a result of the development, manufacture, use or sale of
any Product by Biosite or any of its Sublicensees. Epimmune shall have the right
to be represented by counsel of its own selection, at its own expense, and shall
cooperate fully in the defense of such suit and furnish to Biosite all evidence
and assistance in its control. If Biosite declines to bring such action or
proceeding, then Epimmune shall have the right, at its discretion, to control at
its own expense the defense of such charges of infringement, and Biosite shall
have the right, at its own expense, to be represented in any such action by
counsel of its own choice.

              (c) The party controlling the suit under Section 5.3(c) may not
settle the suit or otherwise consent to an adverse judgment in such suit, if
such settlement or judgment would diminish the rights or interests of the
non-controlling party, without the prior written consent of the non-controlling
party, which consent shall not be unreasonably withheld or delayed.

                                    ARTICLE 6

                     REPRESENTATIONS; WARRANTIES; COVENANTS

       6.1 CORPORATE POWER. Each Party hereby represents and warrants that it is
duly organized, validly existing and in good standing under the laws of the
state or jurisdiction of its incorporation or formation and has full corporate
power and authority to enter into this Agreement and to carry out the provisions
hereof.

       6.2 DUE AUTHORIZATION. Each Party hereby represents and warrants that it
is duly authorized to execute and deliver this Agreement and to perform its
obligations hereunder.

       6.3 BINDING AGREEMENT. Each Party hereby represents and warrants that
this Agreement is a legal and valid obligation binding upon it and is
enforceable in accordance with its terms, and that the execution, delivery and
performance of this Agreement by such Party does not conflict with any
agreement, instrument or understanding, oral or written, to which it is a party
or by which it may be bound, nor violate any law or regulation of any court,
governmental body or administrative or other agency having authority over it.

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       6.4 EXISTING RIGHTS. Epimmune represents and warrants that, as of the
Effective Date, the Patent Rights are existing and, to the best of its
knowledge, are not invalid or unenforceable, in whole or in part.

       6.5 RIGHT AND TITLE. Epimmune represents and warrants that, as of the
Effective Date, to the best of its knowledge, it owns the sole right, title and
interest in and to the Licensed Technology.

       6.6 DISCLAIMER OF WARRANTIES. EXCEPT AS EXPRESSLY SET FORTH IN THIS
AGREEMENT, NEITHER PARTY MAKES ANY REPRESENTATION OR WARRANTY TO ANY OTHER PARTY
OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING, WITHOUT LIMITATION, ANY WARRANTY OF
TITLE, NON-INFRINGEMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE.

       6.7 GOVERNMENTAL APPROVALS; COMPLIANCE WITH APPLICABLE LAWS. Biosite
shall be responsible for obtaining all necessary governmental approvals for the
conduct of any research and development of Products, including the conduct of
any clinical trials, at Biosite's expense. Biosite shall conduct such activities
in compliance with all applicable laws and regulations.

       6.8 INDEMNIFICATION.

              (a) Biosite hereby agrees to save, defend, indemnify and hold
harmless Epimmune and its officers, directors, employees, consultants and agents
from and against any and all losses, damages, liabilities, expenses and costs,
including reasonable legal expense and attorneys' fees ("Losses"), to which any
of them may become subject as a result of any claim, demand, action or
proceeding by any Third Party to the extent such Losses arise out of (i) the
research, development, manufacture, use or sale by Biosite or its Sublicensees
of Products, (ii) the conduct of any research and development by Biosite or its
Sublicensees, including, without limitation, clinical trials, conducted with
respect to the Products, (iii) a breach by Biosite of any of its representations
and warranties contained in this Article 6, (iv) any material breach by Biosite
of this Agreement, (v) any Product, or (vi) the gross negligence or willful
misconduct of Biosite or its Affiliates or Sublicensees in performance of this
Agreement, except to the extent such Losses result from the negligence or
willful misconduct of Epimmune. In the event a party entitled to indemnification
under this Section 6.8(a) seeks indemnification hereunder, it shall inform
Biosite of a claim as soon as reasonably practicable after it receives notice of
the claim, shall permit Biosite to assume direction and control of the defense
of the claim (including the right to settle the claim solely for monetary
consideration), and shall cooperate as requested (at the expense of Biosite) in
the defense of the claim.

              (b) Epimmune hereby agrees to save, defend, indemnify and hold
harmless Biosite and its respective officers, directors, employees, consultants
and agents from and against any and all Losses to which any of them may become
subject as a result of any claim, demand, action or proceeding by any Third
Party to the extent such Losses arise out of (i) a breach by Epimmune of any of
its representations and warranties contained in this Article 6, (ii) any
material breach by Epimmune of this Agreement, or (iii) the gross negligence or
willful misconduct of Epimmune or its Affiliates in performance of this
Agreement, except to the extent such Losses result from the negligence or
willful misconduct of Biosite. In the event a Party entitled to indemnification
under this Section 6.8(b) seeks indemnification hereunder, it shall inform
Epimmune of a claim as soon as reasonably practicable after it receives notice
of the claim, shall permit Epimmune to assume direction and control of the
defense of the claim (including the right to settle the claim solely for
monetary consideration), and shall cooperate as requested (at the expense of
Epimmune) in the defense of the claim.

                                    ARTICLE 7

                                TERM; TERMINATION

              7.1 TERM. This Agreement shall commence as of the Effective Date
and shall continue indefinitely, unless terminated as provided herein (the
"Term").

              7.2 TERMINATION. Biosite may terminate this Agreement at any time
by written notice to Epimmune. Epimmune may terminate this Agreement prior to
the expiration of the Term only if Biosite fails to make payment

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when due under Section 3.1, and such breach is not cured within [...***...]
after Epimmune provides Biosite with written notice thereof.

       7.3 BANKRUPTCY. In the event bankruptcy proceedings are instituted
against Epimmune or on Epimmune's behalf, then the Parties hereby acknowledge
and agree that Biosite may elect to retain its rights under this Agreement as
provided in 11 U.S.C. Section 365(n).

       7.4 EFFECT OF TERMINATION. Upon termination of this Agreement, all rights
under the Licensed Technology shall revert to Epimmune; provided, however, that
Biosite and its Sublicensees shall have the right to sell their inventory of
Products then on hand. Within thirty (30) days following the expiration or
termination of this Agreement, each Party shall return to the other Party, or
destroy, upon the written request of the other Party, any and all Confidential
Information of the other Party in its possession. Expiration or termination of
this Agreement shall not relieve the Parties of any obligation accruing prior to
such expiration or termination. The provisions of Sections 2.4, 6.6, 6.8 and 7.3
and Articles 1, 4, 5, and 8 shall survive termination or expiration of this
Agreement.

                                    ARTICLE 8

                                  MISCELLANEOUS

       8.1 ASSIGNMENT. Except as expressly provided hereunder, neither this
Agreement nor any rights or obligations hereunder may be assigned or otherwise
transferred by either Party without the prior written consent of the other Party
(which consent shall not be unreasonably withheld); provided, however, that
either Party may assign this Agreement and its rights and obligations hereunder
without the other Party's consent (a) with respect to Epimmune, in connection
with the transfer or sale to a Third Party of all or substantially all of the
business of Epimmune to which this Agreement relates, whether by merger, sale of
stock, sale of assets or otherwise, (b) with respect to Biosite, in connection
with the transfer or sale to a Third Party of all or substantially all of the
business of Biosite related to commercial in vitro diagnostic products to which
this Agreement relates, whether by merger, sale of stock, sale of assets or
otherwise, or (c) to any Affiliate. The rights and obligations of the parties
under this Agreement shall be binding upon and inure to the benefit of the
successors and permitted assigns of the parties. Any assignment not in
accordance with this Agreement shall be void.

       8.2 FORCE MAJEURE. No Party shall be held liable or responsible to any
other Party nor be deemed to have defaulted under or breached this Agreement for
failure or delay in fulfilling or performing any term of this Agreement (other
than non-payment) when such failure or delay is caused by or results from causes
beyond the reasonable control of the affected Party, including, without
limitation, fire, floods, earthquakes, natural disasters, embargoes, war, acts
of war (whether war be declared or not), insurrections, riots, civil commotions,
strikes, power outages, lockouts or other labor disturbances, acts of God or
acts, omissions or delays in acting by any governmental authority or any other
Party to this Agreement.

       8.3 GOVERNING LAW. This Agreement shall be governed by, and construed and
enforced solely and exclusively in accordance with, the laws of the State of
California, U.S.A., without regard to its choice of law provisions.

       8.4 LIMITATION OF LIABILITY. EXCEPT (A) TO THE EXTENT ANY AMOUNTS PAYABLE
UNDER ARTICLE 3 CONSTITUTE PROFIT, (B) FOR LIABILITY FOR BREACH OF ARTICLE 4 OR
(C) FOR ANY CLAIM (OUTSIDE OF THE SCOPE OF THIS AGREEMENT) OF INFRINGEMENT OF
THE LICENSED TECHNOLOGY, NEITHER PARTY SHALL BE LIABLE TO THE OTHER FOR ANY
SPECIAL, PUNITIVE, CONSEQUENTIAL, INCIDENTAL OR INDIRECT DAMAGES ARISING OUT OF
THIS AGREEMENT, HOWEVER CAUSED, UNDER ANY THEORY OF LIABILITY. NOTWITHSTANDING
THE FOREGOING, THE LIMITATIONS ON DAMAGES SET FORTH IN THIS SECTION 8.4 SHALL IN
NO WAY LIMIT A PARTY'S OBLIGATIONS TO MAKE INDEMNIFICATION PAYMENTS UNDER
SECTION 6.8.

       8.5 WAIVER. Except as specifically provided for herein, the waiver from
time to time by a Party of any right or failure to exercise any remedy shall not
operate or be construed as a continuing waiver of the same right or remedy or of
any other of such Party's rights or remedies provided under this Agreement.

                                               *CONFIDENTIAL TREATMENT REQUESTED

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       8.6 SEVERABILITY. In case any provision of this Agreement shall be
invalid, illegal or unenforceable, the validity, legality and enforceability of
the remaining provisions shall not in any way be affected or impaired thereby.

       8.7 INDEPENDENT CONTRACTORS. It is expressly agreed that Epimmune and
Biosite shall be independent contractors and that the relationship among them
shall not constitute a partnership, joint venture or agency of any kind. No
Party shall have the authority to make any statements, representations or
commitments of any kind, or to take any action, which shall be binding on any
other Party, without the prior written consent of such other Party.

       8.8 NOTICES. All notices and other communications provided for hereunder
shall be in writing and shall be deemed to have been duly given upon the date of
receipt to the following addresses or facsimile numbers:

       If to Epimmune: EPIMMUNE INC.

       5820 Nancy Ridge Drive
       San Diego, CA  92121
       United States
       Attention: President
       Facsimile: (858) 860-2600

       If to Biosite: BIOSITE INCORPORATED

       11030 Roselle Street, Suite D
       San Diego, California  92121
       Attention: President
       Facsimile: (858) 623-1392

       With a copy to: Gray Cary Ware & Freidenrich LLP

       4365 Executive Drive, Suite 1600
       San Diego, California  92121
       Attention:  Mark R. Wicker
       Facsimile: (858) 677-1477

       Any Party may by like notice specify or change an address to which
notices and communications shall thereafter be sent.

       8.9 ENTIRE AGREEMENT; AMENDMENT. This Agreement (including Appendix I and
Appendix II attached hereto) sets forth all of the agreements and understandings
between the Parties with respect to the subject matter hereof, and supersedes
and terminates all prior and contemporaneous agreements and understandings
between the Parties with respect to the subject matter hereof. There are no
agreements or understandings with respect to the subject matter hereof, either
oral or written, between the Parties other than as set forth herein. Except as
expressly set forth in this Agreement, no subsequent amendment, modification or
addition to this Agreement shall be binding upon the Parties hereto unless
reduced to writing and signed by the respective authorized officers of Epimmune
and Biosite.

       8.10 HEADINGS. The captions contained in this Agreement are not a part of
this Agreement, but are merely guides or labels to assist in locating and
reading the several Articles hereof.

       8.11 COUNTERPARTS. This Agreement may be executed in two or more
counterparts, by facsimile, or both, each of which shall be deemed an original,
but all of which together shall constitute one and the same instrument.

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       IN WITNESS WHEREOF, the Parties have executed this Agreement as of the
date first set forth above.

EPIMMUNE INC.                           BIOSITE INCORPORATED

By: /s/ Robert De Vaere                 By: /s/ Kim D. Blickenstaff
    -----------------------------           ------------------------------
Name: Robert De Vaere                   Name: Kim D. Blickenstaff
     ----------------------------             ----------------------------
Title:  VP, Finance & CFO               Title: President and CEO
      ---------------------------              ---------------------------

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                                   APPENDIX I

[...***...]

                                               *CONFIDENTIAL TREATMENT REQUESTED

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APPENDIX II

                              FORM OF PRESS RELEASE

[...***...]

                                               *CONFIDENTIAL TREATMENT REQUESTED

                                       11<PAGE>
                                                                   Exhibit 10.93

                                            ***TEXT OMITTED AND FILED SEPARATELY
                                                CONFIDENTIAL TREATMENT REQUESTED
                                          UNDER 17 C.F.R. SECTIONS 200.80(b)(4),
                                                            200.83 AND 240.24B-2

                                LICENSE AGREEMENT

        THIS LICENSE AGREEMENT ("Agreement") is made as of this 31 day of
August, 2001 (the "Effective Date"), by and between AP Cells Inc., a company
organized under the laws of California ("AP Cells"), and Epimmune Inc., a
corporation organized under the laws of the State of Delaware ("Epimmune").

        WHEREAS, Epimmune owns or has a license to certain patent rights and
know-how as described herein; and

        WHEREAS, AP Cells desires to obtain a license under Epimmune's rights in
such patent rights and know-how to develop and commercialize products for use in
the Field in the Territory (each as defined below);

        NOW, THEREFORE, in consideration of the foregoing premises and the
mutual covenants herein contained, the parties hereby agree as follows:

                                   ARTICLE 1
                                   DEFINITIONS

        For purposes of this Agreement, the terms defined in this Article 1
shall have the respective meanings set forth below:

        1.1 "ADDITIONAL RIGHTS" shall have the meaning set forth in Section
3.4.1.

        1.2 "AFFILIATE" shall mean, with respect to any Person, any other Person
that directly or indirectly controls, is controlled by, or is under common
control with, such Person. A Person shall be regarded as in control of another
Person if it owns, or directly or indirectly controls, at least fifty percent
(50%) of the voting stock or other ownership interest of the other Person, or if
it directly or indirectly possesses the power to direct or cause the direction
of the management and policies of the other Person by any means whatsoever.

        1.3 "ANTIGEN PATENT RIGHTS" shall mean the antigens and patents and
patent applications listed in Appendix A hereto, and any corresponding foreign
counterparts thereof, and all patents issuing thereon (including utility, model
and design patents and certificates of invention), including any division,
continuation, continuation-in-part or substitution of any such patent
application, and any reissue, extension, confirmation, registration,
re-examination or inventor's certificate of any such patent, together with any
corresponding foreign counterparts of the foregoing.

        1.4 "AP CELLS IMPROVEMENTS" shall mean all Improvements owned by or
licensed to AP Cells (with the right to license or sublicense) during the term
of this Agreement, excluding AP Cells' interest in any Joint Improvements and
any Improvements licensed to AP Cells by Epimmune under Section 3.1.

<PAGE>

        1.5 "BLA" shall mean Biologic License Application or any equivalent
successor application or equivalent application in other countries or
jurisdictions in the Territory.

        1.6 "DOLLARS" or "$" means United States dollars.

        1.7 "EPIMMUNE IMPROVEMENTS" shall mean all Improvements owned by or
licensed to Epimmune (with the right to license or sublicense) during the term
of this Agreement, excluding Epimmune's interest in any Joint Improvements and
any Improvements licensed to Epimmune by AP Cells under Section 9.1.2.

        1.8 "EPIMMUNE PRODUCT" shall mean any product that uses or incorporates
any Improvement licensed to Epimmune pursuant to Section 9.1.2.

        1.9 "FDA" shall mean the United States Food and Drug Administration or
any successor entity.

        1.10 "FIELD" shall mean (a) ex vivo therapeutic applications in cancer;
(b) applications for the purpose of selecting and monitoring patients with
cancer and the treatment of such patients, in either case of (a) or (b) where
such applications involve the use of dendritic cells or other antigen-presenting
cells, immortalized cells or exosomes produced by any of the foregoing cells to
produce or modulate a human immune system response to cancer; and (c) ex vivo
therapeutic use of synthetic exosomes to produce or modulate a human immune
system response to cancer. For such purposes, it is understood that "use" of
antigen-presenting cells includes, without limitation, modification,
differentiation, activation, expansion or other manipulation of such cells,
exosomes, derivatives or precursors.

        1.11 "GMP" shall mean current good manufacturing practices under FDA
rules and regulations.

        1.12 "IMPROVEMENT" shall mean any patentable invention or discovery that
constitutes an enhancement, improvement or modification to the Antigen Patent
Rights or the Process Patent Rights (or, if the Peptide Option is exercised, the
Additional Rights) and is owned by or licensed to a party (with the right to
license or sublicense) during the term of this Agreement, and any and all
patents and patent applications covering such invention or discovery, and any
corresponding foreign counterparts thereof, and all patents issuing thereon
(including utility, model and design patents and certificates of invention),
including any division, continuation, continuation-in-part or substitution of
any such patent application, and any reissue, extension, confirmation,
registration, re-examination or inventor's certificate of any such patent,
together with any corresponding foreign counterparts of the foregoing. The
parties agree that this definition of "Improvement" specifically excludes a
patentable invention or discovery comprised of a combination of such Antigen
Patent Rights or Process Patent Rights (or, if the Peptide Option is exercised,
the Additional Rights) with intellectual property owned or controlled by AP
Cells (other than the intellectual property licensed from Epimmune pursuant to
this Agreement).

        1.13 "IND" means the Investigational New Drug application or any
equivalent successor application or equivalent application in other countries or
jurisdictions in the Territory.

        1.14 "JAPAN OPTION" shall have the meaning set forth in Section 3.5.

                                       2.
<PAGE>

        1.15 "JOINT IMPROVEMENTS" shall have the meaning set forth in Section
9.1.1.

        1.16 "LICENSE" shall have the meaning set forth in Section 3.1.

        1.17 "LICENSED KNOW-HOW" shall mean all inventions, discoveries, trade
secrets, experience, data, sequence information, formulas, computer models,
procedures, results, materials and assays, and all improvements thereon, owned
by or licensed to Epimmune (with the right to license or sublicense), which are
not included in the Licensed Patent Rights, but which are necessary or useful to
the commercial exploitation of the Licensed Patent Rights and which are not
generally publicly known, as set forth on Appendix B hereto.

        1.18 "LICENSED PATENT RIGHTS" shall mean the Antigen Patent Rights, the
Process Patent Rights, the Epimmune Improvements and Epimmune's interest in any
Joint Improvements (and, if the Peptide Option is exercised, the Additional
Rights for which the Peptide Option has been exercised).

        1.19 "LICENSED PRODUCT" shall mean any product that contains,
incorporates, or uses any Licensed Technology.

        1.20 "LICENSED TECHNOLOGY" shall mean, collectively, the Licensed Patent
Rights and Licensed Know-How.

        1.21 "NET SALES" shall mean the invoiced sales price of any Licensed
Product billed by AP Cells or its Affiliates or sublicensees to Third-Party
customers, or of any Epimmune Product billed by Epimmune or its Affiliates or
sublicensees to Third-Party customers, as applicable, in each case less the
following amounts to the extent included in the invoiced sales price: (a)
credits, discounts and rebates to, and chargebacks from the account of, such
Third-Party customers for any spoiled, damaged, out-dated, rejected or returned
product; (b) actual shipping and handling, freight and insurance costs incurred
in transporting such product in final form to such Third-Party customers; and
(c) sales, use, value-added and other taxes or governmental charges incurred in
connection with the exportation or importation of such product in final form.

        1.22 "PEPTIDE OPTION" shall have the meaning set forth in Section 3.4.1.

        1.23 "PEPTIDE OPTION PERIOD" shall have the meaning set forth in Section
3.4.2.

        1.24 "PERSON" shall mean an individual, corporation, partnership, trust,
business trust, association, joint stock company, joint venture, pool,
syndicate, sole proprietorship, unincorporated organization, governmental
authority or any other form of entity not specifically listed herein.

        1.25 "PHASE III" shall mean that portion of the clinical development
program of a Licensed Product which provides for the continued trials of the
Licensed Product on sufficient numbers of patients to establish the safety and
efficacy of the Licensed Product for the desired claims and indications, as more
specifically defined by the rules and regulations of the FDA and corresponding
rules and regulations in other countries or jurisdictions in the Territory.

                                       3.
<PAGE>

        1.26 "PROCESS PATENT RIGHTS" shall mean U.S. Patent 6,037,135, "Methods
for making HLA binding peptides and their uses" and any corresponding foreign
counterparts thereof, and all patents issuing thereon (including utility, model
and design patents and certificates of invention), including any division,
continuation, continuation-in-part or substitution of any such patent
application, and any reissue, extension, confirmation, registration,
re-examination or inventor's certificate of any such patent, together with any
corresponding foreign counterparts of the foregoing.

        1.27 "TERRITORY" shall mean world-wide, except Japan.

        1.28 "THIRD PARTY" shall mean any Person other than Epimmune, AP Cells
and their respective Affiliates.

        1.29 "VALID PATENT CLAIM" shall mean a claim or disclosure of an issued
and unexpired patent included within the Licensed Patent Rights, which has not
been held permanently revoked, unenforceable, unpatentable or invalid by a
decision of a court or other governmental agency of competent jurisdiction,
unappealable or unappealed within the time allowed for appeal, and which has not
been admitted to be invalid or unenforceable through reissue or disclaimer or
otherwise.

                                   ARTICLE 2
                         REPRESENTATIONS AND WARRANTIES

        2.1 REPRESENTATIONS AND WARRANTIES OF EACH PARTY. Each party hereby
represents and warrants to the other party as follows:

            2.1.1 Such party (a) is duly organized, validly existing and in good
standing under the laws of the jurisdiction in which it is organized; (b) has
the power and authority and the legal right to own and operate its property and
assets, to lease the property and assets it operates under lease, and to carry
on its business as it is now being conducted and (c) is in compliance with all
requirements of applicable law, except to the extent that any noncompliance
would not have a material adverse effect on the properties, business, financial
or other condition of it and would not materially adversely affect its ability
to perform its obligations under this Agreement.

            2.1.2 Such party (a) has the power and authority and the legal right
to enter into this Agreement and to perform its obligations hereunder and (b)
has taken all necessary action on its part to authorize the execution and
delivery of this Agreement and the performance of its obligations hereunder.
This Agreement has been duly executed and delivered on behalf of such party, and
constitutes a legal, valid, binding obligation, enforceable against such party
in accordance with its terms.

            2.1.3 As of the Effective Date, the execution and delivery of this
Agreement and the performance of such party's obligations hereunder (a) do not
conflict with or violate any requirement of applicable laws or regulations, and
(b) do not conflict with, or constitute a default under, any contractual
obligation of such party.

                                       4.
<PAGE>

        2.2 REPRESENTATIONS AND WARRANTIES OF EPIMMUNE. Epimmune represents and
warrants to AP Cells as of the Effective Date that :

            2.2.1 Epimmune is the sole and exclusive owner or licensee of the
Licensed Technology in the Field and has the right to grant the License
hereunder.

            2.2.2 Appendix A hereto identifies all patents and patent
applications owned or licensed by Epimmune associated with the antigens listed
therein.

            2.2.3 To the best of Epimmune's knowledge: (a) there are no pending
or threatened claims of litigation brought by a Third Party under any Third
Party patent, trade secret or other Third Party intellectual property right
regarding the Licensed Technology; and (b) the practice by AP Cells of the
Licensed Technology as contemplated herein does not infringe any issued Third
Party patent.

                                   ARTICLE 3
                            LICENSE AND OPTION GRANTS

        3.1 LICENSED TECHNOLOGY. Epimmune hereby grants to AP Cells a
non-exclusive, non-transferable (except pursuant to Section 13.4) license under
the Licensed Technology to make and have made (including the right to make
derivatives), use and sell Licensed Products and to use the Licensed Technology,
in each case in the Field in the Territory during the term of this Agreement
(the "License").

        3.2 SUBLICENSES. AP Cells shall have the right to grant sublicenses
under the License solely to its Affiliates and corporate partners to whom AP
Cells has licensed or also licenses its own technology for use in conjunction
with such sublicense. AP Cells shall deliver a copy of each sublicense under
this Agreement to Epimmune promptly after execution of the same, with any
financial or confidential terms of such agreements, other than those relevant,
in AP Cells' opinion, to Epimmune, redacted. Each sublicense shall be consistent
with the terms and conditions of this Agreement.

        3.3 EPIMMUNE OBLIGATIONS.

            3.3.1 Within fifteen (15) days following the execution of this
Agreement, Epimmune shall deliver to AP Cells such Licensed Know-How as is owned
by Epimmune at such time; provided that GMP manufactured peptides included in
the Licensed Know-How will be provided to AP Cells at an additional cost to be
negotiated in good faith.

            3.3.2 Epimmune agrees to provide AP Cells with reasonable access to
its facilities and employees at reasonable times for the purpose of
demonstrating to AP Cells the assay processes included in the Licensed Know-How
that may be necessary or useful to AP Cells' development, manufacture, use or
sale of Licensed Products. Consultation by Epimmune's employees at Epimmune's
facilities shall be limited to [***...]. In addition, consultation bY Epimmune's
employees by teleconference shall be limited to [...***...].

        3.4 PEPTIDE LICENSE OPTION.

                                               *CONFIDENTIAL TREATMENT REQUESTED

                                       5.
<PAGE>

            3.4.1 Epimmune hereby grants to AP Cells an option (the "Peptide
Option") to include under the License any or all of the peptides listed on
Appendix C and Appendix D hereto, together with all associated patents and
patent applications listed on Appendix C and Appendix D, as applicable, and any
corresponding foreign counterparts thereof, and all patents issuing thereon
(including utility, model and design patents and certificates of invention),
including any division, continuation, continuation-in-part or substitution of
any such patent application, and any reissue, extension, confirmation,
registration, re-examination or inventor's certificate of any such patent,
together with any corresponding foreign counterparts of the foregoing
(collectively, the "Additional Rights"). As Additional Rights with respect to
new peptides come into Epimmune's possession or control, Epimmune will update
Appendix C promptly to reflect such additional peptides, and AP Cells shall be
entitled to exercise its Peptide Option with respect to such peptides; Appendix
D will not be updated to include additional peptides. Epimmune represents and
warrants that, upon exercise by AP Cells of a Peptide Option, Appendix C or
Appendix D, as applicable, hereto identifies all patents and patent applications
associated with the peptides listed therein that are owned or licensed (with
right to license or sublicense as provided for herein) by Epimmune, and there
exist no limitations on Epimmune's right to license such Additional Rights as
contemplated hereby. Epimmune agrees that, during the Peptide Option Period (as
defined below), it shall not enter into any agreement or arrangement that would
limit Epimmune's right to license the Additional Rights to AP Cells upon
exercise of the Peptide Option.

            3.4.2 The Peptide Option may be exercised at any time during the
period ending on the earlier of (a) [...***...] from the Effective Date, or (b)
[...***...] from enrollment of the First patient in AP Cells' first clinical
trial for a Licensed Product (the "Peptide Option Period"). AP Cells may
exercise the Peptide Option, in whole or in part on a peptide-by-peptide basis,
upon written notice to Epimmune, together with a payment to Epimmune of (i)
[...***...] per peptide listed on Appendix C with respect to which the Peptide
Option is exercised and (ii) [...***...] per peptide listed on Appendix D with
respect to which the Peptide Option is exercised. Upon the exercise of the
Peptide Option during the Peptide Option Period and payment of the specified
amount to Epimmune, the term "Licensed Patent Rights" will include the
Additional Rights for which the Peptide Option has been exercised.

        3.5 JAPAN OPTION. Epimmune hereby grants to AP Cells an irrevocable
option (the "Japan Option") to include Japan in the Territory if Epimmune
regains rights to the Licensed Technology in the Field in Japan. Epimmune will
provide written notice to AP Cells promptly upon regaining rights to the
Licensed Technology in the Field in Japan. The Japan Option may be exercised at
any time during the term of this Agreement following the date of such written
notice from Epimmune. AP Cells may exercise the Japan Option upon written notice
to Epimmune together with payment of [...***...]. Upon the exercise of the Japan
Option and payment of the specified amount to Epimmune, the term "Territory"
will include Japan.

                                   ARTICLE 4
                 LICENSE FEES, ROYALTIES AND MILESTONE PAYMENTS

        4.1 LICENSE FEES. In consideration for the License, AP Cells shall pay
to Epimmune a non-refundable license fee of [...***...] by wire transfer of
immediately available funds as

                                               *CONFIDENTIAL TREATMENT REQUESTED

                                       6.
<PAGE>

follows: [...***...] payable on the Effective Date and [...***...] payable upon
AP Cells receiving Epimmune's notice pursuant to Section 3.5 that the Japan
Option has become available.

        4.2 ROYALTIES.

            4.2.1 In further consideration for the License, during the term of
this Agreement, AP Cells shall pay to Epimmune a royalty of [...***...] of Net
Sales of Licensed Products sold or manufactured in a country for which a Valid
Patent Claim is included in the Licensed Patent Rights.

            4.2.2 With respect to any Licensed Product sold or manufactured in a
specific country for which there is no Valid Patent Claim included in the
Licensed Patent Rights AP Cells shall pay to Epimmune a royalty on Net Sales of
such Licensed Product equal to a [...***...] reduction from the rate set forth
in Section 4.2.1.

            4.2.3 In the event AP Cells becomes obligated to pay royalties to a
Third Party for patent rights or technology utilized in or with a Licensed
Product, AP Cells may deduct [...***...] of the royalties paid to such Third
Party from the royalties owing to Epimmune for such Licensed Product; provided,
however, the royalty amounts paid to Epimmune may not be reduced by more than an
aggregate of [...***...] pursuant to the reductions permitted in Section 4.2.2
and this Section 4.2.3.

        4.3 MULTIPLE ROYALTIES. No multiple royalty shall be payable on a
Licensed Product because the manufacture, use or sale of such Licensed Product
is covered by more than one Licensed Patent Right.

        4.4 MILESTONE PAYMENTS. As further consideration for the License, AP
Cells shall pay Epimmune non-refundable milestone payments in cash in the
following amounts upon the occurrence of each of the following events with
respect to any Licensed Product developed by AP Cells or its Affiliates or
sublicensees; provided that each milestone payment shall be made only once and
upon the first occurrence of such milestone for the first Licensed Product for
which such milestone is achieved:

<TABLE>
<CAPTION>
              --------------------------------------------------------------
              MILESTONE                           MILESTONE PAYMENT
              --------------------------------------------------------------
              <S>                                 <C>
              [...***...]
              --------------------------------------------------------------

</TABLE>

            4.4.1 For purposes of this Agreement, AP Cells and Epimmune agree
that [...***...] means the first filing of an [...***...] of a Licensed Product
that includes any MHC Class I peptide within the Antigen Patent Rights.

                                   ARTICLE 5
                         ROYALTY REPORTS AND ACCOUNTING

        5.1 REPORTS. Each party and its Affiliates and sublicensees shall keep
complete and accurate records in sufficient detail to properly reflect all gross
sales and Net Sales of such party and its Affiliates and sublicensees and to
enable the royalties payable hereunder to be determined. The party obligated to
pay royalties hereunder (the "Paying Party") shall provide

                                               *CONFIDENTIAL TREATMENT REQUESTED

                                       7.
<PAGE>

such a royalty report to the other party (the "Receiving Party") within
[...***...] of the end of each fiscal quarter in which royalties are due to the
Receiving Party hereunder.

        5.2 AUDITS.

            5.2.1 Upon the written request of the Receiving Party, and not more
than [...***...] in each calendar year, the Paying Party shall permit a
reasonably acceptable independent certified public accounting firm, selected by
the Receiving Party, at the Receiving Party's expense, to have access during
normal business hours to such of the records of the Paying Party as may be
reasonably necessary to verify the accuracy of the royalty reports hereunder.
The accounting firm shall disclose to the Receiving Party only whether the
records are correct or not and the specific details concerning any
discrepancies. No other information shall be shared.

            5.2.2 If such accounting firm concludes that additional royalties
were owed during such period, the Paying Party shall pay the additional
royalties within [...***...] of the date the Receiving Party delivers to the
Paying Party such accounting firm's written report so concluding. The fees
charged by such accounting firm shall be paid by the Receiving Party; provided
however, if the audit discloses that the royalties payable by the Paying Party
for the audited period are more than [...***...] of the royalties actually paid
for such period, then the Paying Party shall pay the reasonable fees and
expenses charged by such accounting firm.

            5.2.3 Upon the expiration of [...***...] following the end of any
year, the calculation of royalties payable with respect to such year shall be
binding and conclusive upon the Receiving Party and the Paying Party and its
Affiliates and its sublicensees.

        5.3 CONFIDENTIAL FINANCIAL INFORMATION. The Receiving Party shall treat
all financial information subject to review under this Article 5 or under any
sublicense agreement as confidential, and shall cause its accounting firm to
retain all such financial information in confidence.

                                   ARTICLE 6
                                    PAYMENTS

        6.1 PAYMENT TERMS. Royalties shown to have accrued by each royalty
report provided for under Article 5 above shall be due and payable upon the date
such royalty report is due. Payment of royalties in whole or in part may be made
in advance of such due date. Milestone payments shall be due and payable in
accordance with Section 4.4.

        6.2 PAYMENT METHOD. All payments by a party to the other party under
this Agreement shall be paid in Dollars, and all such payments shall be made by
check or bank wire transfer in immediately available funds to such account as
the party entitled to payment hereunder shall designate before such payment is
due.

        6.3 EXCHANGE CONTROL. If at any time legal restrictions prevent the
prompt remittance of part or all royalties with respect to any country where the
Product is sold, payment shall be made through such lawful means or methods as
the party entitled to such payment reasonably shall request.

                                               *CONFIDENTIAL TREATMENT REQUESTED

                                       8.
<PAGE>

        6.4 WITHHOLDING TAXES. In the event that AP Cells is required to
withhold any tax to the tax or revenue authorities in any country in the
Territory regarding any payment to Epimmune due to the laws of such country or
collect and/or pay any sales, use, excise or value added taxes, such amount
shall be deducted from the payment to be made by AP Cells, and AP Cells shall
notify Epimmune and promptly furnish Epimmune with copies of any tax certificate
or other documentation evidencing such withholding. Each party agrees to
cooperate with the other party in claiming exemptions from such deductions or
withholdings under any agreement or treaty from time to time in effect.

        6.5 LATE PAYMENT. In the event that any payment under Article 4 or
Section 9.1.2 is not made when due, the payment shall accrue interest from the
date due at the rate of [...***...]; provided, however, that in no event shall
such rate exceed the maximum legal annual interest rate. The payment of such
interest shall not limit a party from exercising any other rights it may have as
a consequence of the lateness of such payment.

                                   ARTICLE 7
                      INFRINGEMENT ACTIONS BY THIRD PARTIES

        If AP Cells, or any of its Affiliates, sublicensees or customers becomes
the subject of a suit by a Third Party that alleges infringement of a Third
Party's patent arising out of the manufacture, use or sale of Licensed Products
and the alleged infringing process, method or composition is claimed under the
Licensed Patent Rights or otherwise provided to AP Cells as Licensed Technology,
AP Cells shall promptly notify Epimmune in writing of the institution of such
suit. As between the parties, AP Cells shall have the right, subject to the
reasonable approval of Epimmune, to control the defense of such suit at AP
Cells' own expense, in which event Epimmune shall have the right to be
represented by advisory counsel of its own selection, at its own expense, and
shall cooperate fully in the defense of such suit and furnish to AP Cells all
evidence and assistance in Epimmune's control. If AP Cells does not elect within
thirty (30) days after such notice to so control the defense of such suit,
Epimmune may undertake such control at its own expense, and AP Cells shall then
have the right to be represented by advisory counsel of its own selection, at
its own expense, and AP Cells shall cooperate fully in the defense of such suit
and otherwise furnish to Epimmune all evidence and assistance in AP Cells'
control. The party controlling the suit shall not enter into any settlement of
such suit or otherwise consent to an adverse judgment in such suit that admits
the invalidity or unenforceability of any patent within the Licensed Patent
Rights, or the unpatentability of any invention covered by a patent application
within the Licensed Patent Rights, or exceeds the rights under the Licensed
Technology granted hereunder. Any judgments, settlements or damages payable with
respect to legal proceedings covered by this Article 7 shall be paid by the
party that controls the litigation, subject to indemnification under Article 10
and to Section 4.2.3.

                                   ARTICLE 8
                                 CONFIDENTIALITY

        8.1 CONFIDENTIAL INFORMATION. During the term of this Agreement, and for
a period of five (5) years following the expiration or earlier termination
hereof, each party shall maintain in confidence all confidential information of
the other party disclosed to it by the other party (the "Confidential
Information"), and shall not use, disclose or grant the use of Confidential
Information of the other party except on a need-to-know basis to those
directors, officers,

                                               *CONFIDENTIAL TREATMENT REQUESTED

                                       9.
<PAGE>

affiliates, employees, permitted licensees, permitted assignees and agents,
consultants, lawyers, bankers, existing or potential investors, acquirors,
merger partners, collaborators or licensees, clinical investigators or
contractors, to the extent such disclosure is reasonably necessary in connection
with such party's activities as expressly authorized by this Agreement or for
the limited purpose of evaluating a transaction, investment, or license
involving such party. To the extent that disclosure is authorized by this
Agreement, prior to disclosure, each party hereto shall obtain agreement of any
such Person to hold in confidence and not make use of the Confidential
Information for any purpose other than those permitted by this Agreement. Each
party shall notify the other promptly upon discovery of any unauthorized use or
disclosure of the other party's Confidential Information.

        8.2 PERMITTED DISCLOSURES. The confidentiality obligations contained in
Section 8.1 above shall not apply to the extent that (a) any receiving party
(the "Recipient") is required (i) to disclose information by law, order or
regulation of a governmental agency or a court of competent jurisdiction, or
(ii) to disclose information to any governmental agency for purposes of
obtaining approval to test or market a product, provided in either case that the
Recipient shall provide written notice thereof to the other party and sufficient
opportunity to object to any such disclosure or to request confidential
treatment thereof, or (b) the Recipient can demonstrate that (i) the disclosed
information was public knowledge at the time of such disclosure to the
Recipient, or thereafter became public knowledge, other than as a result of
actions of the Recipient in violation hereof; (ii) the disclosed information was
rightfully known by the Recipient (as shown by competent written records) prior
to the date of disclosure to the Recipient by the other party hereunder; (iii)
the disclosed information was disclosed to the Recipient on an unrestricted
basis from a source unrelated to any party to this Agreement and not under a
duty of confidentiality to the other party or (iv) the disclosed information was
independently developed by the Recipient without use of the Confidential
Information disclosed by the other party (as shown by competent written
records).

        8.3 TERMS OF THIS AGREEMENT. Except as otherwise provided in Section 8.2
above, Epimmune and AP Cells shall not disclose any terms or conditions of this
Agreement to any Third Party without the prior consent of the other party, which
consent shall not be unreasonably withheld or delayed. However, each party may
disclose the existence and terms of this Agreement without the other party's
approval to the extent such party concludes, after consulting with its legal
advisors, that it is required by any local, state or federal rule, regulation,
statute or law relevant to the activities undertaken pursuant to this Agreement
or applicable to either of the parties with respect to any matters set forth
herein or by any applicable stock exchange or trading market to disclose this
Agreement or the terms hereof.

        8.4 PUBLICATION. Neither party shall submit for written or oral
publication or presentation any manuscript, abstract, writing, printed material
or the like which includes data or any other information generated and/or
provided solely by the other party without first obtaining the prior written
consent of such other party, which consent shall not be unreasonably withheld or
delayed, provided, however, that if in the opinion of the non-publishing party,
it is believed that any such publication contains (a) a patentable development,
submission for publication shall be delayed to permit the filing of appropriate
patent application or patent applications, but in no event shall such delay
exceed ninety (90) days from the time either party receives such advanced

                                      10.
<PAGE>

copy of the proposed publication or (b) a party's Confidential Information, such
information shall be deleted from the proposed publication is requested in
writing.

                                    ARTICLE 9
                                     PATENTS

        9.1 OWNERSHIP OF INVENTIONS.

            9.1.1 All right, title and interest in and to any Improvements that
are (a) authorized or made by, on behalf of or at the request of AP Cells shall
be the sole property of AP Cells, (b) authorized or made by, on behalf of or at
the request of Epimmune shall be the sole property of Epimmune, and (c) made
jointly by AP Cells and Epimmune shall be the joint property of AP Cells and
Epimmune ("Joint Improvements"). Each party may freely practice any Joint
Improvements outside the Field.

            9.1.2 AP Cells hereby grants to Epimmune a non-exclusive, worldwide,
royalty-bearing license to any AP Cells Improvements for all uses outside the
Field. Such license shall bear a royalty of [...***...] on Net Sales of Epimmune
Products. Epimmune may sublicense its rights under the license to its Affiliates
and Third Parties to whom Epimmune also licenses its own technology in
conjunction with such sublicense. AP Cells shall promptly notify Epimmune in
writing of any AP Cells Improvements licensed to Epimmune under this Section
9.1.2.

            9.1.3 All right, title and interest in and to any discoveries or
inventions arising hereunder that are not Improvements that are authorized or
made by, on behalf of or at the request of AP Cells shall be the sole property
of AP Cells, and AP Cells may freely practice such inventions within and outside
the Field.

        9.2 PROSECUTION AND MAINTENANCE.

            9.2.1 Epimmune shall be responsible for the preparation, filing,
prosecution, maintenance and defense of its patents and patent applications
included in the Licensed Patent Rights at its own expense. In the event that
Epimmune elects not to file a patent application or decides to abandon any
pending application or granted patent under the Licensed Patent Rights in any
country, Epimmune shall provide adequate notice to AP Cells and give AP Cells
the opportunity to file or maintain such application or patent at its own
expense, subject to the rights of any other licensee of the Licensed Patent
Rights, which Epimmune shall fully disclose to AP Cells at such time; provided,
however, that except for the right to file and maintain such patent rights, the
ownership rights of Epimmune to such patent rights shall not be affected by
reason of this paragraph. Epimmune further agrees that, in the event AP Cells so
files or maintains such application or patent at its own expense, AP Cells shall
be entitled to deduct such reasonable expense from any other amounts due
Epimmune.

            9.2.2 AP Cells shall control the prosecution, grant and maintenance
of patents and patent applications included in the Joint Improvements, using
patent counsel reasonably acceptable to Epimmune, provided that AP Cells shall
provide Epimmune with the opportunity to review and comment on filings and other
actions with respect to such patents and patent applications included in Joint
Improvements. AP Cells and Epimmune shall share equally all

                                               *CONFIDENTIAL TREATMENT REQUESTED

                                      11.
<PAGE>

costs incurred in connection therewith; provided, however, that if Epimmune
disagrees with filing for any patent or patent application included in the Joint
Improvements in a given country, Epimmune may elect not to share the costs
incurred in connection with filing, prosecution, maintenance and defense of such
patent or patent application upon written notice to AP Cells, and AP Cells shall
pay all such costs in such country; provided further that AP Cells will be
entitled to credit such costs in such country incurred by AP Cells against
royalties payable to Epimmune under Section 4.2 on Net Sales of Licensed
Products in such country. AP Cells shall inform Epimmune at regular intervals,
or on request, about the status of joint patent applications or joint patents
for which it is responsible. In the event that AP Cells elects not to file a
patent application or decides to abandon any pending application or granted
patent included in Joint Improvements in any country, AP Cells shall provide
adequate notice to Epimmune and give Epimmune the opportunity to file or
maintain such application or patent at its own expense, and all right title
interest in such application or patent for such country shall thereupon be
assigned to Epimmune.

            9.2.3 AP Cells shall be responsible for the preparation, filing,
prosecution, maintenance and defense of its patents and patent applications
included in the AP Cells Improvements. In the event that AP Cells elects not to
file a patent application or decides to abandon any pending application or
granted patent included in the AP Cells Improvements in any country, AP Cells
shall provide adequate notice to Epimmune and give Epimmune the opportunity to
file or maintain such application or patent at its own expense, subject to the
rights of any other licensee of such patent rights; provided, however, that
except for the right to file and maintain such patent rights, the ownership
rights of AP Cells to such patent rights shall not be affected by reason of this
paragraph.

        9.3 COOPERATION. Each party shall make available to the other party or
its authorized attorneys, agents, consultants or representatives, if available,
such information necessary or appropriate to enable the appropriate party (at
the appropriate party's cost and expense) to file, prosecute and maintain patent
applications and resulting patents with respect to Improvements, as set forth in
Section 9.2 above, for a period of time reasonably sufficient for such party to
obtain the assistance it needs from such personnel. Where appropriate, each
party shall sign or cause to have signed all documents relating to said patent
applications or patents at no charge to the other.

        9.4 NO OTHER TECHNOLOGY RIGHTS. Except as specifically and expressly
provided in this Agreement, under no circumstances shall a party, as a result of
this Agreement, obtain any ownership interest or other right in any technology,
know-how, patents, pending patent applications, products, compounds, materials,
vaccines, antibodies, cell lines or cultures, or animals of the other party,
including items owned, controlled or developed by the other, or transferred by
the other to such party at any time pursuant to this Agreement.

        9.5 NOTIFICATION OF INFRINGEMENT. Each party shall notify the other
party of any significant and continuing infringement known to such party of any
patent rights included in Joint Improvements or patent rights of the other party
and shall provide the other party with the available evidence, if any, of such
infringement.

                                      12.
<PAGE>

                                   ARTICLE 10
                                    INDEMNITY

        10.1 INDEMNITY.

            10.1.1 Epimmune shall indemnify and hold AP Cells harmless, and
hereby forever releases and discharges AP Cells, from and against all losses,
liabilities, damages and expenses (including reasonable attorneys' fees and
costs) resulting from all claims, demands, actions and other proceedings (each a
"Claim") by any Third Party to the extent arising from: (a) the breach of any
representation, warranty or covenant of Epimmune under this Agreement; (b) the
development, manufacture, use or sale of Epimmune Products by Epimmune or its
Affiliates or sublicensees; or (c) the gross negligence or willful misconduct of
Epimmune in the performance of its obligations and its permitted activities
under this Agreement. The foregoing shall not apply to the extent such Claims
result from the gross negligence or willful misconduct of AP Cells.

            10.1.2 AP Cells shall indemnify and hold Epimmune harmless, and
hereby forever releases and discharges Epimmune, from and against all losses,
liabilities, damages and expenses (including reasonable attorneys' fees and
costs) resulting from all Claims by any Third Party to the extent arising from
(a) the breach of any representation, warranty or covenant of AP Cells under
this Agreement, (b) the development, manufacture, use or sale of Licensed
Products by AP Cells or its Affiliates or sublicensees or (b) the gross
negligence or willful misconduct of AP Cells or its Affiliates or sublicensees
in the performance of its or their obligations, and its or their permitted
activities under this Agreement. The foregoing shall not apply to the extent
such Claims result from the gross negligence or willful misconduct of Epimmune.

        10.2 PROCEDURE. A party that intends to claim indemnification under this
Article 10 (the "Indemnitee") shall promptly notify the other party (the
"Indemnitor") in writing of any Claim for which the Indemnitee intends to claim
such indemnification. The Indemnitor shall have the right to participate in, and
to the extent the Indemnitor so desires, jointly with any other indemnitor
similarly noticed, to assume the defense thereof with counsel selected by the
Indemnitor and reasonably mutually satisfactory to both parties. However, the
Indemnitee shall have the right to retain its own counsel, with the fees and
expenses to be paid by the Indemnitor, if representation of the Indemnitee by
the counsel retained by the Indemnitor would be inappropriate due to actual or
potential differing interests between the Indemnitee and any other party
represented by such counsel in such proceedings. The indemnity obligations under
this Article 10 shall not apply to amounts paid in settlement of any Claim if a
settlement is effected without the prior express written consent of the
Indemnitor, which consent shall not be unreasonably withheld or delayed. The
failure to deliver notice to the Indemnitor within a reasonable time after
notice of any such Claim, if prejudicial to its ability to defend such Claim,
shall relieve such Indemnitor of any liability to the Indemnitee under this
Article 10 with respect thereto, but the omission so to deliver notice to the
Indemnitor shall not relieve it of any liability that it may have to the
Indemnitee otherwise than under Article 10. The Indemnitor may not settle or
otherwise consent to an adverse judgment in such Claim that diminishes the
rights or interests of Indemnitee without the prior express written consent of
the Indemnitee, which consent shall not be unreasonably withheld or delayed. The
Indemnitee, its employees and

                                      13.
<PAGE>

agents, shall reasonably cooperate with the Indemnitor and its legal
representatives in the investigation and defense of any Claim covered by this
Article 10.

                                   ARTICLE 11
                                   TERMINATION

        11.1 EXPIRATION. Subject to the provisions of Sections 11.2 and 11.3
below, this Agreement shall expire on a Licensed Product-by-Licensed Product and
country-by-country basis as follows: (i) for Licensed Products for which AP
Cells has a royalty obligation pursuant to Section 4.2.1, on the date which is
the later of (a) [...***...] from the first sale of the applicable Licensed
Product in the applicable country, or (b) the last to expire Valid Claim of the
Licensed Patent Rights which covers the manufacture or sale of such Licensed
Product in such country; and (ii) for Licensed Products for which AP Cells has a
royalty obligation pursuant to Section 4.2.2, on the date which is the later of
(a) [...***...] from the first sale of the applicable Licensed Product in the
applicable country or when all Licensed Know-How used by AP Cells in the
development, making, using or selling of such Licensed Product has become
publicly known otherwise than through the fault of AP Cells or an undertaking
connected therewith. Expiration of AP Cells' royalty obligations for each
Licensed Product under this Section 11.1 shall not preclude AP Cells from
continuing to market such Licensed Product and to use Licensed Technology in
such country without further royalty payments or any other remuneration to
Epimmune.

        11.2 TERMINATION FOR CAUSE. Except as otherwise provided in Article 12,
either party may terminate this Agreement upon or after the breach of any
material provision of this Agreement by the other party if the other party has
not cured such breach within [...***...] after written notice thereof by the
non-breaching party.

        11.3 BANKRUPTCY. In the event of the institution by or against either
party of insolvency, receivership or bankruptcy proceedings or any other
proceedings for the settlement of such party's debts which are not dismissed
within [...***...], or upon such party's making an assignment for the benefit of
creditors, or upon such party's dissolution or ceasing to do business, the other
party shall have the right to terminate this Agreement upon written notice to
such party.

        11.4 EFFECT OF EXPIRATION OR TERMINATION. Expiration or termination of
this Agreement shall not relieve the parties of any obligation accruing prior to
such expiration or termination, and the provisions of Article 1, Sections 5.1
and 5.2 (for one (1) year following the end of the calendar year in which such
expiration or termination occurred), Section 5.3, Article 8, Section 9.1.1,
Articles 10 and 11 and Sections 13.2, 13.3 and 13.4 shall survive the expiration
or termination of this Agreement.

                                   ARTICLE 12
                                  FORCE MAJEURE

        Neither party shall be held liable or responsible to the other party nor
be deemed to have defaulted under or breached this Agreement for failure or
delay in fulfilling or performing any term of this Agreement (other than failure
or delay in making any payment when due) to the

                                               *CONFIDENTIAL TREATMENT REQUESTED

                                      14.
<PAGE>

extent, and for so long as, such failure or delay is caused by or results from
causes beyond the reasonable control of the affected party including but not
limited to fire, floods, embargoes, war, acts of war (whether war be declared or
not), insurrections, riots, commotions, strikes, lockouts or other labor
disturbances, acts of God or acts, omissions or delays in acting by any
governmental authority or other party.

                                   ARTICLE 13
                                  MISCELLANEOUS

        13.1 NOTICES. Any consent, notice or report required or permitted to be
given or made under this Agreement by one of the parties hereto to the other
party shall be in writing, delivered personally, by facsimile (and promptly
confirmed by personal delivery, U.S. first class mail or courier), U.S. first
class mail or courier, postage prepaid (where applicable), addressed to such
other party at its address indicated below, or to such other address as the
addressee shall have last furnished in writing to the addressor and (except as
otherwise provided in this Agreement) shall be effective upon receipt by the
addressee.

If to Epimmune:       Epimmune Inc.
                      5820 Nancy Ridge Drive
                      San Diego, CA 92121
                      United States
                      Attention:    Chief Financial Officer
                      Telephone:    (858) 860-2500
                      Facsimile:    (858) 860-2600

with a copy to:       Cooley Godward LLP
                      4365 Executive Drive, Suite 1100
                      San Diego, CA 92121
                      Attention:    L. Kay Chandler, Esq.
                      Telephone:    (858) 550-6000
                      Facsimile:    (858) 453-3555

If to AP Cells:       AP Cells Inc.
                      1014 Hamilton Court
                      Menlo Park
                      CA 94025  USA
                      Attn:  Henri Mura, Chairman and CEO
                      Telephone:    (650) 321-9500
                      Facsimile:    (650) 324-4733

with a copy to:       Wilson Sonsini Goodrich & Rosati
                      1 Market, Spear Street Tower, Suite 3300
                      San Francisco, CA  94105
                      Attention:  David Boyko, Esq.
                      Telephone:    (415) 947-2104
                      Facsimile:    (415) 947-2099

                                      15.
<PAGE>

        13.2 GOVERNING LAW. This Agreement shall be governed by and construed in
accordance with the laws of the State of California, without regard to the
conflicts of law principles thereof.

        13.3 ARBITRATION. Upon written request by at least one party that is
submitted according to the applicable rules for arbitration, any claim, demand
or cause of action that arises out of or is related to this Agreement
(collectively, "Arbitration Claims") shall be resolved by binding arbitration in
San Diego, California, subject to the rules of the American Arbitration
Association. The decision of an arbitrator on any Arbitration Claims submitted
to arbitration shall follow applicable substantive law and be in writing setting
forth the findings of fact and law and the reasons supporting the decision. Such
decision shall be final and binding upon the parties, subject to the right of
appeal described below. Judgment upon any arbitration award may be entered in
any court having jurisdiction. The arbitrator has exclusive authority to resolve
any dispute relating to the applicability or enforceability of this Agreement,
including the provisions of this section. Either party shall have the right to
appeal to the appropriate court any errors of law in the decision rendered by
the arbitrator. After a demand for arbitration is made, each party may conduct a
limited number of depositions (including the production of documents) by mutual
agreement or as permitted by the arbitrator.

        13.4 ASSIGNMENT. Neither party shall assign its rights or obligations
under this Agreement, in whole or in part, by operation of law or otherwise,
without the prior written consent of the other party; provided however, that
either party may, without such consent, assign this Agreement and its rights and
obligations thereunder in connection with the transfer or sale of all or
substantially all of its business, or in the event of its merger, consolidation,
change in control or similar transaction; provided further that, in the event of
any such transaction, intellectual property rights of any Person, other than AP
Cells or Epimmune or their Affiliates, that is an acquiring party in such
transaction shall not be included in the intellectual property licensed
hereunder. Any purported assignment in violation of this Section 13.4 shall be
void.

        13.5 WAIVERS AND AMENDMENTS. No change, modification, extension,
termination or waiver of this Agreement, or any of the provisions herein
contained, shall be valid unless made in writing and signed by duly authorized
representatives of the parties hereto.

        13.6 ENTIRE AGREEMENT. This Agreement embodies the entire understanding
between the parties and supersedes any prior understanding and agreements
between and among them respecting the subject matter hereof. There are no
representations, agreements, arrangements or understandings, oral or written,
between the parties hereto relating to the subject matter of this Agreement
which are not fully expressed herein.

        13.7 SEVERABILITY. Any of the provisions of this Agreement which are
determined to be invalid or unenforceable in any jurisdiction shall be
ineffective to the extent of such invalidity or unenforceability in such
jurisdiction, without rendering invalid or unenforceable the remaining
provisions hereof and without affecting the validity or enforceability of any of
the terms of this Agreement in any other jurisdiction.

        13.8 WAIVER. The waiver by either party hereto of any right hereunder or
the failure to perform or of a breach by the other party shall not be deemed a
waiver of any other right

                                      16.
<PAGE>

hereunder or of any other breach or failure by said other party whether of a
similar nature or otherwise.

        13.9 CONSTRUCTION. The parties have participated jointly in the
negotiation and drafting of this Agreement. In the event an ambiguity or
question of intent or interpretation arises, this Agreement shall be construed
as if drafted jointly by the parties and no presumption or burden of proof shall
arise favoring or disfavoring any party by virtue of the authorship of any of
the provisions of this Agreement.

        13.10 INDEPENDENT CONTRACTORS. The relationship between Epimmune and AP
Cells is that of independent contractors. Neither party has any actual or
apparent authority, express or implied, to act on behalf of the other party or
to bind the other party to any obligations. Neither party shall be deemed to be
an agent or servant of the other party or a partner or venturer with the other
party. Neither party shall control, or have any right to control, the manner,
method and means by which the other party makes, has made, uses, sells, leases
or otherwise provides or markets its products and services.

        13.11 COUNTERPARTS. This Agreement may be executed in two or more
counterparts, each of which shall be deemed an original, but all of which
together shall constitute one and the same instrument.

                                      17.
<PAGE>

        IN WITNESS WHEREOF, the parties have executed this License Agreement by
their duly authorized representatives as of the date first set forth below.

EPIMMUNE INC.                        AP CELLS INC.

By:  /s/ Robert De Vaere             By:    /s/ Henry Mura
   ---------------------------          -------------------------------

Print Name: Robert De Vaere          Print Name:   Henry Mura
           -------------------                  -----------------------

Title:  VP, Finance & CFO            Title: Chairman and CEO
      ------------------------              ---------------------------

<PAGE>

                                   APPENDIX A

                              ANTIGEN PATENT RIGHTS

[...***...]

                                               *CONFIDENTIAL TREATMENT REQUESTED

<PAGE>

                                   APPENDIX B

                                LICENSED KNOW-HOW

[...***...]

                                               *CONFIDENTIAL TREATMENT REQUESTED

<PAGE>
                                   APPENDIX C

[...***...]

                                               *CONFIDENTIAL TREATMENT REQUESTED

<PAGE>

                                   APPENDIX D

[...***...]

                                               *CONFIDENTIAL TREATMENT REQUESTED

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