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Prepared by MERRILL CORPORATION

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Exhibit 10.67    
  

September 21,
2001 

Liz
Fetter

2888 Sacramento Street

San Francisco, California 94115 

Dear
Liz, 

As
a result of our recent discussions, it is with pleasure that I confirm our verbal offer for your employment with QRS Corporation. The following summarizes our offer: 

POSITION  

President and CEO and Member of the Board of Directors 

REPORTING TO  

Peter R. Johnson, Chairman of the Board. 

LOCATION  

Richmond, California 

START DATE  

As soon as possible but no later than October 15th, 2001 

MISSION STATEMENT  

As a key executive of QRS, you should ensure continued focus on the long-term mission of QRS: 

	•
	QRS
pioneers and delivers business intelligence, technology and services that improve profitability for trading partners in the global retail supply chain.

	•
	QRS
enables these trading partners to increase revenue, decrease cost of sales and improve the return on sales by up to 5 percentage points.

	•
	QRS
products and services ensure the right product, at the right price, is in the right place, at the right time.

	•
	QRS
gets it right, all the time and in every way. 

In
addition, you will have continuing, significant responsibility for the development of QRS' vision, values, structure, management process and people. 

KEY OBJECTIVES  

	(i)
	As
a member of the Board of Directors, protect the interests of all shareholders; while providing the Chairman and Board members with advice and
counsel to assist them ensure that our corporate objectives are met.

	(ii)
	As
a member of the Corporate Management Committee (CMC), work in cooperation with the other CMC team members to realize the company's mission and
strategy.

	(iii)
	As
CEO, succeed in all Key Result Areas 

KEY RESULT AREAS  

As a key executive of QRS, your focus for the remainder of 2001 and in 2002 should be on successfully addressing the critical issues facing QRS. The following specific
objectives have been put forward to encourage more discussion between us during the next several weeks: 

	A.
	Ensure
QRS values, mission, and management process are understood and accepted ensuring commitment to, and appropriate growth of these components of the QRS culture and process,
including the effective integration of these mission, values and management process within QRS and its various units and locations.

	B.
	Meet
or exceed the plan for the remainder of 2001 and quarter-by-quarter for 2002.

	C.
	Significantly
improve performance, execution, efficacy and enthusiasm for the task at hand promoting a culture where performance is measured (at all levels of the organization) and
people are held accountable.

	D.
	Ensure
that QRS' product strategy is congruent with identified customer needs and market opportunities and that the products, their pricing and promotion, establish and maintain our
competitive advantage, correctly positioning QRS to exploit those needs and opportunities for the current year and for the long term.

	E.
	Ensure
the timely development and implementation an effective strategic and annual planning process including SWOT, competitive analysis, the development of market and customer
based three-year strategic plans, critical issue based 2002 operating plan and budgets, and the achievement of agreed upon growth and profitability levels.

	F.
	Ensure
the continued and growing satisfaction of our key customers across all geography and sectors, with particular attention to North American GMA.

	G.
	Continue
to develop the company's organization and people.

	H.
	Improve
the quality of our products and services

	I.
	Promote
QRS with our customers / prospects and the financial community and ensure QRS and Tradeweave are well recognized and highly respected brand names.

	J.
	Support
the Board in its consideration of and implementation of strategic options that maximize shareholder value including but not limited to:

	a)
	Organic
growth from current markets and products accelerated by new, internally funded extensions of markets and products and optionally, minor acquisitions, and

	b)
	A
major acquisition to bring significant growth and increased valuation to the company, in a targeted strategic area, including any necessary external investment to maintain
sufficient control and liquidity for QRS shareholders, or

	c)
	Sale
of the company to a strategic acquirer so as to better ensure execution of the QRS mission and strategy while maximizing shareholder value and minimizing risk. 

In
short, we want you to significantly improve execution, performance and shareholder value. 

ANNUAL COMPENSATION  

Your annual compensation will be administered by me and reviewed by the Compensation Committee of the Board of Directors. 

Key
elements of our agreement that impact compensation are as follows: 

	(i)
	Your
annual base compensation will be $350,000 or $29,166.66 per month. QRS employees are paid
semi-monthly (i.e., on the fifteenth and last working day of each month). 

	(ii)
	In
addition, you will receive annual incentive compensation of $300,000 that will be administered by
me and reviewed by the Compensation Committee. 

During
2001 your short-term incentive compensation will depend on your start date, but assuming October 15th, it should approximate $62,500. 

During
2001 and 2002 you will receive an advance of $8,333.33 each month, or an advance of $100,000 on an annual basis, of your annual incentive compensation, which amounts shall be
non-reimbursable and deemed earned. 

Notwithstanding
the above, the annual total target compensation (base compensation plus incentive at 100%), shall not be less than $650,000 and for 2001
the total target compensation (base compensation plus incentive at 100%) will depend on your start date, but again assuming October 15th, it should approximate $135,500. 

Your
compensation, including incentives, will be reviewed in the first quarter of 2002 and each year thereafter (unless there is a change in objectives, locations, etc., in which case it will be
reviewed at that time), to ensure that it continues to be equitable, appropriate to the location and provide appropriate incentives and support to the agreed objectives. 

REIMBURSEMENT  

QRS will reimburse you for all business expenses reasonably incurred by you in the performance of your duties hereunder. You will adhere to QRS' travel and entertainment
polices and procedures, submit expense reports with appropriate vouchers, receipts, and other substantiation of such expenses within thirty (30) days after they are incurred and you should
expect prompt reimbursement. 

ANNUAL INCENTIVE COMPENSATION COMPONENTS  

	1.
	General
Corporate Financial Objectives (80%)—Incentive compensation payment is subject to the achievement of the Company's overall financial objectives as defined by the
most recent 2001 Plan as approved by the Board of Directors. Should the Company not achieve these financial objectives, incentive compensation will be subjectively determined based upon your
performance against your objectives and the Company's determination as to available incentive compensation funding.

	A.
	Achieve
* in QRS Revenue (40%)—Paid at year-end on a pro rata basis from a minimum of 95% of plan and linearly thereafter with results to 105% of plan. The
payout rate doubles on revenue performance over 105% of plan. There is a maximum payout of $120,000 on this incentive for 2001.

	B.
	Achieve
* in QRS Earnings Before Interest, Tax, Depreciation and Amortization (EBITDA) (40%)—Paid at year-end on a pro rata basis from a minimum of 95% of
plan and linearly thereafter with results to 105% of plan. The payout rate doubles on earnings performance over 105% of plan. There is a maximum payout of $120,000 on this incentive for 2001. 

	*
	Certain
confidential information contained in this document, marked by asterisks, has been omitted and filed separately with the Securities and Exchange Commission pursuant to
Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

	2.
	Personal
Strategies and Objectives (20%)—Incentive compensation payment is subject to fulfillment of your specific objectives as CEO. While key objectives and key result
areas have been noted above to measure your performance for incentive compensation, such measurements assume the overall performance of you and your direct reporting organization in the achievement of
Company responsibilities, customer services levels, employee satisfaction and turnover, and the support of overall Company objectives. 

LONG TERM INCENTIVES  

It will be recommended that you receive a stock option grant of 300,000 shares in accordance with the defined plan, copies of which are available for your review. This
recommendation will be presented to the Compensation Committee of the Board of Directors at their first meeting subsequent to your start date. The grant date will be the date the Board approves the
grant, and the option price will be established by the closing price of the stock on that date. 

200,000
of these options will vest over a four-year period with 25% vesting on the first anniversary of your employment and the remainder vesting in equal monthly increments thereafter. 

100,000
of these options will vest based on specific performance. Specifically, options to purchase another 25,000 shares of common stock in QRS will be granted to you and will be considered to be
fully vested when you accomplish the 2001 revenue and profit plan described above. In addition, options to purchase an additional 75,000 shares of common stock (i.e., for a total of 100,000
performance-based options) in QRS will be granted to you and will be considered to be fully vested when the company establishes and maintains a stock price of more than $30 for more than
15 days. In any event these performance-based options will vest on the sixth anniversary of your employment. 

BENEFITS  

In addition to the benefits available to all QRS associates as defined in the Employee Handbook; as a Senior Vice President and Officer you are provided with additional
benefits as follows: 

Disability
Insurance—The Company shall purchase and maintain in effect disability insurance sufficient to provide you with an income equal to 66% of your base compensation while you are
disabled and unable to perform the duties of your current employment with QRS. You will have the option of continuing this additional disability insurance coverage at your own expense in the event of
the termination of your employment. This additional insurance benefit is taxable and will be reported for tax purposes as additional income to you. 

Liability
Insurance—The Company shall purchase and maintain in effect sufficient Officer's liability insurance to provide you with reasonable coverage, including the provision of legal
counsel and/or reimbursement of appropriate legal fees you pay personally, against all liability claims and judgments arising from your legal exercise of your duties as an Officer of QRS, including
any actions filed after you cease your duties as an Officer or in the event of the termination of your employment. The Company shall also provide in its bylaws, a full indemnification for you as a QRS
officer, to the maximum extent permissible under Delaware law. 

TERMINATION AND SEVERANCE  

This position is for no set period or term and just as you have the right to resign your position, at any time, for any reason, QRS reserves the right to terminate your
employment, at any time, with or without cause, with or without notice. 

For
the period ending twelve months from your start date (i.e. on or before October 2002), in the event your employment is terminated without cause, you will become entitled to twelve
(12) months of severance pay equal in the aggregate to your targeted total annual compensation and benefits at the level in effect at the time of your termination. After that initial period
(i.e., after October 2002), in the event your employment is terminated without cause, you will become entitled to twelve (12) months of severance pay equal in the aggregate to your base
compensation and benefits at the level in effect at 

the time of your termination. Your severance payments will be made in accordance with the Company's standard payroll practices for current employees and will be subject to the Company's collection of
all applicable withholding taxes. 

For
purposes of this agreement, termination "for cause" shall mean a termination of your employment for any of the following reasons: (1) your failure to substantially perform the material
duties of your position with the Company after a written demand for substantial performance is delivered to you by the Company which specifically identifies the manner in which you have not
substantially performed those duties and which provides a reasonable period for you to cure those deficiencies; (2) a material breach by you of your obligations under any confidential or
proprietary information agreements with the Company or of any of your fiduciary obligations as an officer of the Company, (3) your failure to follow in a material respect the reasonable
policies or directives established on an employee-wide basis by the Company, after written notice to you indicating the policies or directives with which you are not in material
compliance, (4) any willful misconduct on your part having a material detrimental effect on the Company or (5) any unauthorized activity on your part which creates a material conflict of
interest between you and the Company after you have been provided with a reasonable opportunity to refrain from that activity. 

CHANGE OF CONTROL BENEFITS  

	A.
	Should
there occur a Corporate Transaction or a Change in Control (as those terms are defined in the Company's 1993 Stock Option/Stock Issuance Plan) and either (i) your
employment is subsequently terminated without cause or (ii) you subsequently resign by reason of a material change in your base compensation, your targeted annual incentive compensation, your
annual total target compensation, or your benefits (for this purpose, 15% will be deemed a material reduction), a material reduction in your duties or responsibilities, or a change in your principal
place of employment by more than 50 miles, then you will be entitled to twelve (12) months of severance pay equal in the aggregate to your targeted total annual compensation and benefits at the
level in effect at the time of your termination or resignation or (if greater) at the level in effect immediately prior to the Corporate Transaction or Change in Control. Your severance payments will
be made in accordance with the Company's standard payroll practices for current employees and will be subject to the Company's collection of all applicable withholding taxes.

	B.
	Except
to the extent otherwise provided in paragraph C below, should a Corporate Transaction or Change in Control occur during your period of employment with the Company,
then (i) all of your outstanding options will, immediately prior to the specified effective date for the Corporate Transaction or Change in Control, become exercisable for all the shares at the
time subject to those options, whether or not those options are to be assumed or replaced with a cash incentive program, and those accelerated options may be exercised for all or any portion of the
option shares as fully vested shares; and (ii) all of your unvested shares of QRS stock will immediately vest at the time of such Corporate Transaction or Change in Control.

	C.
	However,
the following limitation will be in effect for (i) all of your unvested shares of QRS stock and (ii) any unvested options which are to be assumed by the
successor entity (or parent company) or otherwise continued in effect or which are to be replaced with a cash incentive program which preserves the spread existing at the time of such Corporate
Transaction or Change in Control on any shares for which your options are not otherwise at that time exercisable (the excess of the fair market value of those shares over the exercise price): 

The
accelerated vesting of those unvested shares and options will be limited to the extent and only to the extent necessary to assure that the parachute payment attributable to the accelerated vesting
of those shares and options would not constitute an excess parachute payment under Internal Revenue Code Section 280G(b). 

To
the extent one of more of your options or unvested shares do not vest on an accelerated basis upon a Corporate Transaction or Change in Control by reason of such limitation, those options 

will continue to become exercisable in accordance with the original exercise schedule indicated in the respective grant notices for those options, and those unvested shares will continue to vest in
accordance with the original vesting schedule set forth in the applicable Restricted Stock Agreements. However, should either (i) your employment be terminated without cause or (ii) you
resign by reason of a material
change in your base compensation, your targeted annual incentive compensation, your annual total target compensation, or your benefits (for this purpose, 15% will be deemed a material reduction), a
material reduction in your duties or responsibilities, or a change in your principal place of employment by more than 50 miles, at the time of such Corporate Transaction or Change in Control or within
twenty four (24) months thereafter, then each of your outstanding options, to the extent not otherwise fully exercisable at that time, shall automatically accelerate and become immediately
exercisable for all the option shares and may be exercised for any or all of those shares as fully vested shares at any time prior to the expiration or sooner termination of the option term. In
addition, all of your unvested shares will immediately vest upon such a termination of employment or resignation. 

	D.
	Any
of your options which are assumed by the successor entity (or parent company) in the Corporate Transaction or are otherwise continue in effect following the Change in Control
transaction shall be appropriately adjusted to apply and pertain to the number and class of securities which would have been issued to you in the consummation of such Corporate Transaction or Change
in Control had the options been exercised immediately prior to such event. Appropriate adjustments shall also be made to the option prices payable per share, provided the aggregate option prices
payable shall remain the same. 

EMPLOYMENT AT WILL  

Your employment in the position of Chief Executive Officer will remain an Employment At Will. This means that your position is
for no set period or term and just as you have the right to resign your position, at any time, for any reason, QRS reserves the right to terminate your employment, at any time, with or without cause
and with or without notice. If any contrary representation has been made to you, this letter supersedes it. Neither subsequent agreement contrary to this nor any amendment to this term can be made
unless it is in writing and signed by both of us and copied to the Chairman of the Compensation Committee. 

I
trust the above meets your approval. However, should you have any questions or concerns, you should not hesitate to contact either Garth Saloner or myself. For our part we look forward, with
tremendous enthusiasm, to you joining QRS and our ongoing relationship. 

Sincerely,

	  /s/ Peter R. Johnson
 Peter R. Johnson, Chairman of the Board

	 	 

c.c.:  Garth
Saloner—Chairman of the Compensation Committee  

I
accept this ongoing position with QRS Corporation on these terms and conditions on the terms above and understand and agree that it supersedes any other agreement, written or oral, I may have with
QRS with respect to employment or compensation by QRS including salary, incentive, options, termination and severance. 

	/s/ Elizabeth Fetter
 Liz Fetter	 	September 24, 2001
 Date

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Exhibit 10.67<Page>

                             NOTE PURCHASE AGREEMENT

            NOTE PURCHASE AGREEMENT, dated as of November 9, 2001 (this
"Agreement"), by and between Kevin Kimberlin Partners, L.P., a Delaware limited
partnership ("Buyer"), and The Immune Response Corporation, a Delaware
corporation ("Seller").

            WHEREAS, Seller desires to issue to Buyer, and Buyer has agreed to
purchase from Seller, a convertible secured promissory note substantially in the
form of EXHIBIT A hereto (the "Initial Note") in the principal loan amount of
$2,000,000, which will be convertible and prepayable as set forth herein;

            WHEREAS, to induce Buyer to make such a loan, Seller has agreed to
issue to Buyer a warrant (the "Initial Warrant") to purchase a 1,733,703 shares
of Seller's common stock, $.0025 par value per share (the "Common Stock"), which
equals $2,000,000 divided by eighty (80%) percent of the exercise price per
share, which will initially equal the average of the closing bid prices of the
Common Stock for the ten (10) consecutive trading days immediately preceding the
issuance date of the Initial Warrant (the "Exercise Price"), subject to the
adjustments as set forth in the warrant agreement substantially in the form of
EXHIBIT B hereto (the "Warrant Agreement"); and

            WHEREAS, in connection with, and as a condition to, the issuance and
purchase of the Initial Note, Seller and Buyer have agreed, subject to (among
other terms and conditions set forth herein) the achievement of the commercial
and technical milestones to be set forth on a written schedule (the "Milestone
Schedule") to be reasonably negotiated by the parties as soon as reasonably
practicable following the Initial Closing (as defined in Section 2.1 hereof),
that the Seller will issue, and the Buyer will purchase, additional convertible
secured promissory notes (the "Additional Notes" and each, an "Additional Note";
and together with the Initial Note, the "Notes"), each in the form of the
Initial Note and each in the principal amount to be reasonably agreed to (up to
$2,000,000) by the parties, and additional warrants (the "Additional Warrants"
and each, an "Additional Warrant"; and together with the Initial Warrant, the
"Warrants") to purchase, pursuant to an additional warrant agreement (the
"Additional Warrant Agreement"; and together with the Warrant Agreement, the
"Warrant Agreements"), the number of shares of the Common Stock equal to the
principal loan amount of such corresponding Additional Note divided by eighty
(80%) percent of the exercise price per share of such Additional Warrants, which
exercise price shall be equal to the average of the closing bid prices of the
Common Stock for the ten (10) consecutive trading days immediately preceding the
issuance date of such Additional Warrant, determined and adjusted in accordance
with, and subject to the same terms and conditions provided in, the Warrant
Agreement.

            NOW, THEREFORE, in consideration of the premises and the
representations, warranties, covenants and agreements herein contained, the
parties hereby agree as follows:

            1. PURCHASE AND SALE.

            1.1 SALE OF NOTES AND WARRANTS. At the Initial Closing, Seller shall
issue to Buyer, and Buyer shall purchase from Seller, for the Purchase Price (as
defined in Section 1.2(a) hereof), the Initial Note and the Initial Warrant
(together, the "Securities"). Subject to

<Page>

Section 1.3 hereof, at each and any of the Subsequent Closings (as defined in
Section 2.1 hereof), Seller shall issue to Buyer, and Buyer shall purchase from
Seller, for the applicable Additional Purchase Price (as defined in Section
1.2(a) hereof), an Additional Note and an Additional Warrant (together, the
"Additional Securities").

            1.2 PURCHASE PRICE AND PAYMENT.

                  (a) PURCHASE PRICE. The aggregate purchase price for the
Securities shall be $2,000,000 (the "Purchase Price"). The aggregate purchase
price for any Additional Securities shall be the principal amount of each
Additional Note (the "Additional Purchase Price"). The parties hereby agree that
ninety-five (95%) percent of the Purchase Price (or, as applicable, of the
Additional Purchase Price) will be allocated to each of the Notes and five (5%)
percent of the Purchase Price (or, as applicable, of the Additional Purchase
Price) will be allocated to each of the Warrants.

                  (b) PAYMENT OF PURCHASE PRICE. The Purchase Price or, as
applicable, the Additional Purchase Price shall be paid to Seller by Buyer on
the applicable Closing Date (as defined in Section 2.1 hereof) via federal funds
wire transfer(s) of immediately available funds in accordance with written
instructions to be provided to Buyer by Seller at least two (2) business days
prior to the applicable Closing Date.

            1.3 SALE OF ADDITIONAL SECURITIES. Provided that the Initial Closing
shall have occurred, subject to the other conditions contained herein, Buyer
shall acquire, and Seller shall issue, Additional Securities for the applicable
Additional Purchase Price if Seller shall have achieved, in accordance with the
Milestone Schedule, the scheduled milestone(s) on or before the applicable date
that such milestone(s) was to be achieved.

            2. CLOSING.

            2.1 INITIAL CLOSING; SUBSEQUENT CLOSINGS. The closing of the sale
and purchase of the Initial Note and the issuance of the Initial Warrant (the
"Initial Closing"), and the closing of any sale and purchase of Additional Notes
and issuance of other Additional Warrants (the "Subsequent Closings"; and
together with the Initial Closings, the "Closings") shall be deemed to take
place at the offices of Kirkpatrick & Lockhart LLP, 1251 Avenue of the Americas,
45th Floor, New York, NY 10020, at 10:00 a.m., local time, on such date as Buyer
and Seller may mutually agree in writing. The date upon which the Initial
Closing shall occur is herein called the "Initial Closing Date" and the date
upon which any of the Subsequent Closings shall occur is herein called the
"Subsequent Closing Date"; each, a "Closing Date".

            2.2 CLOSING DELIVERIES.

                  (a) SELLER DELIVERIES. Unless otherwise indicated herein, at
each of the Closings, Seller shall deliver or cause to be delivered to Buyer the
following:

                        (i) the duly executed Initial Note or Additional Note,
as the case may be;

                                       2
<Page>

                        (ii) a duly executed Intellectual Property Security
Agreement (as defined in Section 3.6 hereof) and duly executed UCC-1 financing
statements, at the Initial Closing;

                        (iii) a duly executed Warrant Agreement or Additional
Warrant Agreement, as the case may be;

                        (iv) copies of any consents of all persons necessary to
effectuate this Agreement and to consummate the transactions contemplated
hereby;

                        (v) a legal opinion, dated as of the applicable Closing
Date, of Pillsbury Winthrop LLP, counsel to Seller, reasonably satisfactory in
form and substance to Buyer; and

                        (vi) written evidence of Nasdaq Consent (as defined in
Section 6.2(c) hereof); PROVIDED, HOWEVER, that such evidence shall not be
required at the Initial Closing.

                  (b) BUYER DELIVERY. At each of the Closings, Buyer shall
deliver or cause to be delivered to Seller the Purchase Price or, as applicable,
the Additional Purchase Price.

            3. TERMS OF THE NOTES.

            3.1 AMOUNT. The principal amount of the Initial Note shall be
$2,000,000 and the principal amount of any Additional Note shall be the amount
to be listed on the Milestone Schedule.

            3.2 MATURITY. Unless otherwise converted into the Conversion Shares
(as defined in Section 3.4 hereof) in accordance with the provisions hereof or
unless extended in writing by Buyer in its sole discretion, each of the Notes
shall mature on the three-year anniversary date of the date of issuance of such
Note (each, a "Note Maturity Date"). On the applicable Note Maturity Date of any
of the Notes, unless converted into the Conversion Shares in accordance with the
provisions hereof, all outstanding principal and any accrued and unpaid interest
due and owing on such Note shall be immediately paid by Seller.

            3.3 INTEREST; INTEREST RATE; PAYMENT. (a) Each of the Notes shall
bear interest at a rate equal to eight (8%) percent (the "Interest Rate") per
annum based on a 365-day year and shall be payable quarterly in arrears.
Interest (other than interest accruing as a result of a failure by Seller to pay
any amount when due as set forth in subsection (b) below) in respect of each of
the Notes shall accrue until all amounts remaining owed under such Note shall be
fully repaid or the date on which such Note shall be fully converted into
Conversion Shares (the "Conversion Date"), as the case may be, and shall be
payable in full on the earlier of (i) the Note Maturity Date, (ii) if only the
principal of such Note shall have been converted, and such conversion shall have
occurred prior to the Note Maturity Date, ten (10) days after the Conversion
Date or (iii) otherwise in accordance with Section 6.2(c)(iii) hereof; PROVIDED,
HOWEVER, that any interest accruing on overdue amounts pursuant to subsection
(b) of this Section 3.3 shall be payable on demand.

                                       3
<Page>

                  (b) If all or a portion of the principal amount of any of the
Notes or any interest payable thereon shall not be repaid when due whether on
the applicable repayment date, by acceleration or otherwise, such overdue
amounts on such Note shall bear interest at a rate per annum that is three (3%)
percent above the Interest Rate (I.E., 11%) from the date of such non-payment
until such amount is paid in full (after as well as before judgment). All
payments to be made by Seller hereunder or pursuant to the Notes shall be made,
without setoff or counterclaim, in lawful money of the United States by
certified check or wire transfer in immediately available funds.

            3.4 CONVERSION; VOLUNTARY PREPAYMENT. (a) Subject to Section 3.5
hereof, Buyer may convert the principal and/or any accrued and unpaid interest
of any of the Notes, in whole or part, into shares (the "Conversion Shares") of
Common Stock at the Conversion Price (as defined below) at any time and from
time to time on or after the date of issuance of such Note. For purposes hereof,
"Conversion Price" (which shall be hereafter subject to adjustment as provided
in Sections 3.7 and 3.8 hereof) for any of the Notes shall mean the product of
(i) 0.8 multiplied by (ii) the average of the closing bid prices of the Common
Stock for the ten (10) consecutive trading days immediately preceding the
issuance date of such Note. The Conversion Price for the Initial Note, as of the
date hereof, shall be $1.1536. Upon conversion, Buyer shall receive the number
of shares of Common Stock calculated by dividing the principal amount of, and
(at Buyer's election) any interest on, such Note being converted by the
Conversion Price. No fractional shares of Common Stock shall be issued upon
conversion. In lieu of any fractional shares to which Buyer would otherwise be
entitled, Seller shall pay cash in an amount equal to such fraction multiplied
by the Conversion Price. None of the Notes shall be subject to automatic
conversion or to conversion at the option of Seller.

            (b) All or part of any of the Notes may be prepaid by Seller ten
(10) days following receipt by Buyer of written notice thereof from Seller;
PROVIDED, HOWEVER, that any such prepayment on such Note shall be first applied
to accrued and unpaid interest of the outstanding Notes and then against their
outstanding principal in the inverse order of maturity; and PROVIDED, FURTHER,
that if Buyer shall have received such prior written notice that all or any part
of such Note shall be prepaid, Buyer shall be immediately entitled to convert
such Note at the applicable Conversion Price.

            3.5 CONVERSION PROCEDURES. In order to exercise the voluntary
conversion rights set forth in Section 3.4 hereof, Buyer may surrender any of
the Notes, appropriately endorsed, to Seller at Seller's principal office,
accompanied by written notice to Seller (i) stating that Buyer elects to convert
such Note (or portion thereof) and (ii) setting forth the name or names (with
address(es)) in which the Conversion Shares shall be issued and registered on
the books of Seller. The Conversion Date shall be deemed to be the date that
such Note and notice is received by Seller. Within five (5) business days after
the Conversion Date, Seller shall deliver to Buyer a stock certificate or
certificates (in the denominations requested by Buyer) for the Conversion Shares
and/or a notice certified by Seller's Secretary that the Conversion Shares due
on such conversion have been issued to and registered on the books of Seller in
the name or names specified by Buyer.

            3.6 SECURITY. Each of the Notes shall be secured by Seller's
intellectual property (including, without limitation, the patents, trademarks
and tradenames set forth on

                                       4
<Page>

SCHEDULE 4.8(a) hereto) pursuant to and as set forth in the Intellectual
Property Security Agreement substantially in the form of EXHIBIT C hereto, as
the same may be amended, modified, restated or supplemented from time to time
(the "Intellectual Property Security Agreement"), which shall be recorded on or
promptly after the Initial Closing Date with the assignment division of the
United States Patent and Trademark Office.

            3.7 CONVERSION PRICE ADJUSTMENT. (a) The Conversion Price shall be
subject to adjustment as follows:

                  (i) In the event that Seller shall issue additional shares of
capital stock (or securities convertible into or exchangeable for capital stock)
via a stock dividend or stock distribution paid with respect to its Common
Stock, or declare any dividend or other distribution payable with additional
shares of its capital stock (or securities convertible into or exchangeable for
capital stock) with respect to its Common Stock or effect a split or subdivision
of its outstanding shares of Common Stock, the Conversion Price shall,
concurrently with the effectiveness of such stock dividend, stock distribution,
split or subdivision, or the earlier declaration thereof, be proportionately
decreased.

                  (ii) In the event that the outstanding shares of the Common
Stock shall be combined or consolidated, by reclassification, reverse stock
split or otherwise, into a lesser number of shares of Common Stock, the
Conversion Price shall, concurrently with the effectiveness of such combination
or consolidation, be proportionately increased.

                  (iii) In the event that Seller shall issue Additional
Shares of Common Stock (as defined in the Warrant Agreement) without
consideration or for a consideration per share less than the then-applicable
Conversion Price, then and in such event, such Conversion Price shall be
adjusted in the same manner (and in accordance with the adjustment provisions
set forth in the Warrant Agreement) that the Exercise Price (as defined in
the Warrant Agreement) shall be adjusted in the event that Seller shall issue
Additional Shares of Common Stock without consideration or for a
consideration per share less than the then-applicable Exercise Price.

            (b) Upon the occurrence of each adjustment or readjustment of the
Conversion Price pursuant to this Section 3.7, Seller, at its expense, shall
promptly compute such adjustment or readjustment of the Conversion Price in
accordance with the terms hereof and furnish to Buyer a certificate setting
forth such adjustment or readjustment and showing in detail the facts upon which
such adjustment or readjustment is based and, if applicable, shall obtain a
Nasdaq Consent.

            3.8 PRESERVATION OF CONVERSION RIGHTS UPON MERGER, CONSOLIDATION,
ETC. In the case of any consolidation of Seller with, or merger of Seller with
or into, another corporation or entity (other than a consolidation or merger
that does not result in any reclassification or change of the outstanding
capital stock of Seller), or in the case of any sale or conveyance to another
corporation or entity of all or substantially all of the assets of Seller,
Seller or such successor or purchasing corporation or entity, as the case may
be, shall provide in a written agreement to Buyer that Buyer shall have the
right thereafter to be issued upon conversion of any of the Notes in accordance
with its terms the kind and amount of equity interests and/or other securities
and property that Buyer would have owned or have been entitled to receive as a
result of such consolidation, merger, sale or conveyance had such Note been
converted in full immediately prior to such action. At the request of Buyer, the
resulting or surviving entity in any

                                       5
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such transaction, if other than Seller, shall acknowledge in writing Buyer's
rights hereunder. The provisions of this Section 3.8 shall similarly apply to
successive consolidations, mergers, sales or conveyances.

            3.9 ASSURANCES WITH RESPECT TO CONVERSION RIGHTS. Seller shall not,
by amendment of its Certificate of Incorporation or By-laws or through any
reorganization, transfer of assets, consolidation, merger, dissolution, issue or
sale of securities or any other voluntary action, avoid or seek to avoid the
observance or performance of any of the terms to be observed or performed
hereunder by Seller, but shall at all times in good faith assist in the carrying
out of all the provisions of this Agreement and in taking of all such actions as
may be necessary or appropriate in order to protect the conversion rights of
Buyer against impairment or dilution.

            4. REPRESENTATIONS AND WARRANTIES OF SELLER. Seller hereby
represents and warrants to Buyer as follows:

            4.1 DUE ORGANIZATION AND QUALIFICATION. Seller is a corporation duly
organized, validly existing and in good standing under the laws of the State of
Delaware. Seller has all requisite power and authority to own, lease and operate
its assets and properties and to carry on its business as presently conducted
and as presently contemplated. Seller is duly qualified to transact business and
is in good standing in each jurisdiction in which the nature of its business or
the locations of its property requires such qualification, except where the
failure to do so would not have a material adverse effect on Seller's business,
operations, assets or condition (financial or otherwise).

            4.2 POWER AND AUTHORITY. Seller has the requisite corporate power
and authority to execute and deliver this Agreement and all other agreements
contemplated by this Agreement (including, without limitation, the Notes,
Intellectual Property Security Agreement and Warrant Agreements) and to perform
its obligations hereunder and thereunder. The execution, delivery and
performance of this Agreement and all other agreements contemplated by this
Agreement have been duly authorized by all necessary corporate action on the
part of Seller. This Agreement has been duly executed and delivered by Seller
and is the valid and binding obligation of Seller, enforceable against Seller in
accordance with its terms, except as such enforceability may be limited by
applicable bankruptcy, moratorium, insolvency, reorganization or other similar
laws now or hereafter in effect generally affecting the enforcement of
creditors' rights, specific performance, injunctive or other equitable remedies.
When executed and delivered by Seller at a Closing, each of the Notes, the
Intellectual Property Security Agreement and the Warrant Agreements will be the
valid and binding obligation of Seller, enforceable against Seller in accordance
with its terms, except as such enforceability may be limited by bankruptcy,
moratorium, insolvency, reorganization or other similar laws now or hereafter in
effect generally affecting the enforcement of creditors' rights, specific
performance, injunctive or other equitable remedies.

            4.3 AUTHORIZATION OF THE NOTES, WARRANTS, CONVERSION AND WARRANT
SHARES. All corporate action on the part of Seller and its stockholders
necessary for the authorization, issuance, sale and/or delivery of the Notes,
the Warrants, the Conversion Shares and the Common Stock issuable upon exercise
of the Warrants (the "Warrant Shares") has been (or, prior to the applicable
Subsequent Closing Date, subject only to obtaining a Nasdaq Consent,

                                       6
<Page>

will be) taken, including, without limitation, the appropriate waiver of the
stockholder rights provided by the Rights Agreement between Seller and First
Interstate Bank, Ltd, as Rights Agent, dated as of February 26, 1992, or any
other similar anti-takeover protections. The issuance, sale and/or delivery of
the Initial Note and the Initial Warrant shall not require a Nasdaq Consent. The
Conversion Shares and the Warrant Shares, when converted or exercised in
accordance with this Agreement, will be validly issued and outstanding, fully
paid and nonassessable, and neither they nor any of the Notes or Warrants will
trigger or be subject to any preemptive, anti-dilution, ratchet, voting, change
of control, first offer or refusal or other similar rights of any stockholder of
Seller or other that shall not have been irrevocably and unconditionally waived
as of the Initial Closing.

            4.4 COMPLIANCE WITH LAWS. Seller is in compliance in all material
respects with all Federal, state, local and foreign laws, statutes, ordinances,
regulations, orders, judgments, injunctions, awards or decrees (collectively,
"Laws") applicable to it or any of its properties or operations. Seller has not
received any notice of material violation or alleged material violation of any
Law by it. Seller has all licenses, permits, orders and approvals of Federal,
state, local and foreign governmental or regulatory bodies necessary for the
conduct of its business and operations.

            4.5 NO BREACH; CONSENTS. The execution, delivery and performance of
this Agreement by Seller and the consummation by Seller of the transactions
contemplated hereby will not (i) result in any lien, pledge, mortgage, security
interest, claim, lease, charge, option, easement, servitude or other encumbrance
whatsoever (collectively, "Liens") upon any of the property of Seller (other
than in favor of Buyer) or (ii) violate, conflict with or otherwise result in
the breach of any of the terms and conditions of, result in a material
modification of, accelerate or trigger the rights of any person under, or
constitute (or with notice or lapse of time or both would constitute) a default
under (a) any material instrument, contract or other agreement to which Seller
is a party or by or to which it or any of its properties is bound or subject;
(b) Seller's Certificate of Incorporation or By-laws (and all amendments thereto
up through the date hereof); or (c) any Law applicable to Seller or any of its
properties or operations. Except as set forth on SCHEDULE 4.5(a) hereto, no
consent, approval or authorization of, or declaration or filing with, any
governmental authority, stockholder of Seller or other person is required on the
part of Seller in connection with the execution, delivery or performance of this
Agreement or the consummation by it of the transactions contemplated hereby.

            4.6 LITIGATION. Except as disclosed in Seller's SEC Reports (as
defined in Section 4.7 hereof), there are no material suits or actions,
administrative, arbitration or other proceedings or governmental investigations
pending or, to Seller's knowledge, threatened against or affecting Seller or any
of its properties or assets. There are no judgments, orders, injunctions,
decrees or awards against Seller that are not satisfied or remain outstanding.

            4.7 SEC REPORTS. Seller has timely filed the following Seller
reports (the "SEC Reports") with the Securities and Exchange Commission pursuant
to the Securities Exchange Act of 1934, as amended (the "Exchange Act"): (a)
annual reports on Form 10-K for the years ended December 31, 1998, 1999 and
2000; (b) quarterly reports on Form 10-Q for the quarters ended March 31, 2001
and June 30, 2001; and (c) proxy statements for the years 1998, 1999 and 2000.
As of their respective dates, none of the SEC Reports or statements or

                                       7
<Page>

communication provided therein contained any untrue statement of a material fact
or omitted to state any material fact required to be stated therein or necessary
in order to make the statements therein, in light of the circumstances under
which they were made, not misleading. There is no fact, occurrence, condition or
development known to Seller that materially adversely affects the business,
properties, prospects or financial condition of Seller that has not been set
forth in the SEC Reports.

            4.8 INTELLECTUAL PROPERTY. SCHEDULE 4.8(a) hereto sets forth all
material United States and foreign patents, patent applications, service marks,
trade names, trademarks, copyrights, whether registered or unregistered or
existing under statute or common law, and all registrations, applications and
licenses to use any of the foregoing, owned or used by Seller in the conduct of
its business (the "Intellectual Property"). Except as set forth on SCHEDULE
4.8(b) hereto, Seller has full right, title and interest in and to all of such
Intellectual Property, free and clear of any Lien and no third party has any
ownership right, title, interest, claim in or on any of the Intellectual
Property. None of the Intellectual Property nor, to Seller's best knowledge, any
product, formula, formulation, process, method, know-how, substance, part or
other material relating to such Intellectual Property or otherwise being used in
the business of Seller infringes upon or violates any rights owned or held by
any other person. Except as set forth on SCHEDULE 4.8(b), there is not pending
nor, to Seller's knowledge, threatened any claim, suit or action contesting or
challenging the rights of Seller in or to any Intellectual Property or the
validity of any of the Intellectual Property. To Seller's knowledge, there is no
infringement upon or unauthorized use of any of the Intellectual Property by any
third party. Except as set forth on SCHEDULE 4.8(b), there is no liability or
obligation of Seller to pay amounts for the use of any of the Intellectual
Property pursuant to any license or otherwise, and none of the Intellectual
Property is licensed by or to Seller or any of its affiliates (I.E., any other
person controlling, controlled by or under common control with Seller) or
associates (as defined in Rule 405 of the Securities Act of 1933, as amended
(the "Securities Act")). Seller has not received any notice or other
communication indicating that any of the letters patent, service marks or
trademarks included in the Intellectual Property are invalid. No officer,
director, equityholder or affiliate of Seller nor any of their respective
associates has any right to or interest in any of the Intellectual Property,
including, without limitation, any right to payments (by royalty or otherwise)
in respect of any use or transfer thereof. All fees or other amounts due to any
governmental authority in respect of the Intellectual Property, including,
without limitation, any amounts payable in respect of filings, registrations
and/or renewals have been, and will be through the Initial Closing Date, fully
and timely paid. To Seller's knowledge, all technical information developed by
and belonging to Seller that has not been patented has been kept confidential.

            4.9 REGISTRATION RIGHTS. No person or entity has, and as of the
Initial Closing no person or entity will have, demand, "piggy-back", or other
rights to cause Seller to file any registration statement under the Securities
Act relating to any securities of Seller or to participate in any such
registration statement.

            5. REPRESENTATIONS AND WARRANTIES OF BUYER. Buyer hereby represents
and warrants to Seller as follows:

            5.1 DUE ORGANIZATION. Buyer is a limited partnership duly organized,
validly existing and in good standing under the laws of the State of Delaware,
and has the requisite

                                       8
<Page>

partnership power and authority to own, lease and operate its assets and
properties and to carry on its business as presently conducted.

            5.2 POWER OF BUYER. Buyer has the requisite partnership power and
authority to execute and deliver this Agreement and to perform its obligations
hereunder. This Agreement has been duly executed and delivered by Buyer and is
the valid and binding obligation of Buyer, enforceable against Buyer in
accordance with its terms, except as such enforceability may be limited by
bankruptcy, moratorium, insolvency, reorganization or other similar laws
generally affecting the enforcement of creditors' rights, specific performance,
injunctive or other equitable remedies.

            5.3 NO BREACH. The execution, delivery and performance of this
Agreement by Buyer and the consummation by Buyer of the transactions
contemplated hereby will not violate, conflict with or otherwise result in the
breach of any of the terms and conditions of, result in a material modification
of or constitute (or with notice or lapse of time or both would constitute) a
default under (i) any of the organizational documents of Buyer; (ii) any
material instrument, contract or other agreement to which Buyer is a party or by
or to which it or any of its properties is bound or subject; or (iii) any Law
applicable to Buyer or any of its properties or operations.

            5.4 GOVERNMENTAL AND OTHER CONSENTS. No consent, approval or
authorization of, or declaration or filing with, any governmental authority or
other person is required on the part of Buyer in connection with the execution,
delivery and performance of this Agreement by it or the consummation of the
transactions contemplated hereby.

            5.5 INVESTMENT REPRESENTATIONS. Buyer is acquiring the Securities
and the Additional Securities, if any (and any Common Stock issuable upon
conversion or exercise of the Securities or Additional Securities), for Buyer's
own account, for investment and not with a view to, or for sale in connection
with, any distribution of such securities or any part thereof. Buyer (i) has
such knowledge and experience in financial and business affairs that it is
capable of evaluating the merits and risks involved in purchasing the Securities
and any Additional Securities, (ii) is able to bear the economic risks involving
in purchasing the Securities and any Additional Securities, (iii) is an
"accredited investor" as defined in Rule 501(a) of Regulation D promulgated
under the Securities Act and (iv) has had the opportunity to ask questions of,
and receive answers from, Seller and persons acting on Seller's behalf
concerning Seller's business, management, and financial affairs and the terms
and conditions of the Securities and Additional Securities.

            6. COVENANTS AND AGREEMENTS.

            6.1 PRE-CLOSING COVENANTS AND AGREEMENTS. The parties hereto
covenant and agree to perform or take any and all such actions to effectuate the
following from the date hereof until the earlier of the Initial Closing Date or
the termination of this Agreement:

            (a) FURTHER ASSURANCES. Each of the parties shall, prior to or at
the Initial Closing, as may be appropriate, execute such documents and other
papers and take such other further actions as may be reasonably required to
carry out the provisions hereof and effectuate

                                       9
<Page>

the transactions contemplated hereby, and in the Initial Note, the Warrant
Agreement and the Intellectual Property Security Agreement. Each party shall use
its best efforts to fulfill or obtain the fulfillment of the conditions to its
obligation to effect the Initial Closing, including promptly obtaining any
consents required in connection herewith.

            (b) ADDITIONAL DISCLOSURE. Seller shall promptly notify Buyer of,
and furnish Buyer with, any information it may reasonably request with respect
to the occurrence of any event or condition or the existence of any fact that
would cause any of the conditions to Buyer's obligation to consummate the
transactions contemplated by this Agreement not to be fulfilled.

            6.2 POST-CLOSING COVENANTS AND AGREEMENTS. Buyer and Seller covenant
and agree from and after the Initial Closing Date to perform or take the
following actions:

            (a) RESERVE FOR CONVERSION SHARES AND WARRANT SHARES. Subject to
Section 6.2(c) hereof, Seller shall at all times reserve and keep available out
of its authorized but unissued shares of Common Stock for the purpose of issuing
Common Stock upon the conversion in full of any of the Notes and exercise in
full of the Warrants. If at any time the number of authorized but unissued
shares of Common Stock shall not be sufficient to satisfy the conversion in full
of the Notes and exercise of the Initial Warrant and Additional Warrants, if
any, Seller shall, subject to Section 6.2(c), forthwith take such corporate
action as may be necessary to increase its authorized but unissued shares of
Common Stock to such number of shares as shall be sufficient for such purpose.

            (b) REGISTRATION RIGHTS.

                  (i) DEMAND REGISTRATION. At any time on or after the date six
(6) months following the date hereof, Buyer may, by written notice to Seller (a
"Demand Notice"), demand that Seller register for sale under the Securities Act
all or any portion of the Conversion Shares or Warrant Shares (including shares
covered by the Notes and/or Warrants to the extent Seller receives appropriate
assurances that such Notes or Warrants will be converted or exercised prior to
or upon the effectiveness of such registration) held by Buyer (or its successor
in interest or transferee) in the amount and manner specified in the Demand
Notice; PROVIDED, HOWEVER, that the reasonably anticipated aggregate price of
the securities to be registered and offered to the public would exceed $500,000.
Seller shall be obligated to register securities pursuant to this Section
6.2(b)(i) on two (2) occasions only; PROVIDED, HOWEVER, that if Seller is a
registrant then entitled to file a registration statement on Form S-3 or any
successor form thereto, Seller shall be obligated to register Buyer's securities
on one (1) additional occasion if Buyer provides a Demand Notice requesting that
its securities be registered on Form S-3 or any successor form thereto; and
PROVIDED, FURTHER, that any such obligation shall be deemed satisfied only when
a registration statement covering all registrable securities specified in the
Demand Notice shall have become effective.

                  (ii) PIGGYBACK REGISTRATION. If, at any time(s) after the date
hereof, Seller shall determine to register for its own account or the account of
any other(s) under the Securities Act any of its equity securities, it shall
send to Buyer (or its successor in interest) written notice of such
determination and, if within twenty (20) days after receipt of such notice,
Buyer (or its successor in interest or transferee) shall so request in writing,
Seller shall include in

                                       10
<Page>

such registration statement all of the Conversion Shares or Warrant Shares
(including shares covered by the Notes and/or Warrants to the extent Seller
receives appropriate assurances that such Notes or Warrants will be converted or
exercised upon the effectiveness of such registration) held by Buyer (or its
successor in interest or transferee), and requested to be registered.
Notwithstanding the foregoing, in the event that any registration shall be, in
whole or in part, an underwritten offering, the number of registrable securities
to be included in such an underwriting may be reduced (PRO RATA among the Buyer
and its successors or assigns and the holders of the other registrable
securities contemplated being included in such registrations based on the number
of registrable securities requested to be registered by each of them) if and to
the extent that the managing underwriter shall be of the good faith opinion
(expressed in writing) that such inclusion would reduce the number of
registrable securities to be offered by Seller or otherwise adversely affect
such offering. Nothing herein shall be construed so as to require Seller, in
connection with any proposed offering, to engage the services of an underwriter,
as, for example, if Seller shall file a registration statement under Rule 415 of
the Securities Act without the services or engagement of any underwriter. This
"piggy-back" registration right shall not apply to an offering of equity
securities on Form S-4 or S-8 (or their then-equivalent forms) relating to
securities to be issued solely in connection with an acquisition of any entity
or business or securities issuable in connection with a stock option or other
employee benefit plan.

                  (iii) REGISTRATION PROCEDURES. Whenever Seller is required by
this Section 6.2(b) to effect the registration of any securities under the
Securities Act, Seller will:

                        (A) prepare and file with the Securities and Exchange
      Commission (the "Commission") a registration statement with respect to
      such securities as expeditiously as possible after delivery of a Demand
      Notice and in no event later than 90 days after receipt of the Demand
      Notice, and use its best efforts to cause such registration statement to
      become effective under the Securities Act not later than one hundred
      twenty (120) days from the date of the Demand Notice; PROVIDED, HOWEVER,
      that if such Demand Notice requests that Seller register such securities
      on Form S-3, Seller shall use its best efforts to cause such registration
      statement to become effective under the Securities Act not later than
      sixty (60) days from the date of the Demand Notice. Such registration
      statement shall remain effective for the lesser of one hundred eighty
      (180) days or until all of Buyer's securities included in such
      registration statement have been sold ("Requisite Period");

                        (B) promptly prepare and file with the Commission such
      amendments and supplements to such registration statement and the
      prospectus used in connection therewith as may be necessary to keep such
      registration statement effective for the Requisite Period and comply with
      the provisions of the Securities Act with respect to the disposition of
      all securities covered by such registration statement;

                        (C) promptly furnish to Buyer and to each underwriter
      (if any) such number of copies of the registration statement and the
      prospectus included therein (including each preliminary prospectus) as
      Buyer reasonably may request in order to facilitate the intended
      disposition of the securities covered by such registration statement;

                                       11
<Page>

                        (D) use its best efforts (w) to register or qualify the
      securities covered by such registration statement under the securities or
      "blue sky" laws of such jurisdictions as Buyer or, in the case of an
      underwritten public offering, the managing underwriter reasonably shall
      request, (x) to prepare and file in those jurisdictions such amendments
      (including post effective amendments) and supplements, and take such other
      actions, as may be necessary to maintain such registration and
      qualification in effect at all times for the period of distribution
      contemplated thereby, (y) to take such further action as may be necessary
      or advisable to enable the disposition of the securities covered by such
      registration statement in such jurisdictions and (z) to remain a
      registrant entitled to use Form S-3 or any successor form to register the
      re-sale of the securities under the Securities Act; PROVIDED, HOWEVER,
      that Seller shall not for any such purpose be required to qualify
      generally to transact business as a foreign corporation in any
      jurisdiction where it is not so qualified or to consent to general service
      of process in any such jurisdiction;

                        (E) use its best efforts (to the extent eligible
      therefor) to facilitate the listing and reporting of such securities on
      the Nasdaq National Market (the "NNM");

                        (F) immediately notify Buyer and, if applicable, each
      underwriter participating in the offering covered by such registration
      statement, at any time when a prospectus relating thereto is required to
      be delivered under the Securities Act, of the happening of any event of
      which Seller has knowledge as a result of which the prospectus contained
      in such registration statement, as then in effect, includes any untrue
      statement of a material fact or omits to state a material fact required to
      be stated therein or necessary to make the statements therein not
      misleading in light of the circumstances then existing and promptly amend
      or supplement such registration statement to correct any such untrue
      statement or omission;

                        (G) immediately notify Buyer of the issuance by the
      Commission of any stop order suspending the effectiveness of the
      registration statement or the initiation of any proceedings for that
      purpose and use its best effort to prevent the issuance of any stop order
      and, if any stop order is issued, to obtain the lifting thereof at the
      earliest possible time;

                        (H) pay all expenses incurred in complying with this
      Section 6.2(b), including, without limitation, all registration and filing
      fees, printing expenses, fees and expenses (including counsel fees)
      incurred in connection with complying with state securities or "blue sky"
      laws, fees of the National Association of Securities Dealers, Inc. and
      fees of transfer agents and registrars, and Seller shall permit, at
      Seller's expense, subject to the immediately succeeding proviso, a single
      firm of counsel and a single accounting firm designated by Buyer to review
      the registration statement and all amendments and supplements thereto for
      a reasonable period of time prior to their filing; PROVIDED, HOWEVER, that
      in no event shall Seller be required to reimburse Buyer for legal and
      accounting fees in excess of $25,000 per registration statement, and
      Seller shall not file any document in a form to which such counsel
      reasonably objects;

                                       12
<Page>

                        (I) if the offering is an underwritten offering, enter
      into a written agreement with the managing underwriter in such form and
      containing such provisions as are usual and customary in the securities
      business for such an arrangement between such underwriter and companies of
      Seller's size and investment stature, including, without limitation,
      customary indemnification and contribution provisions;

                        (J) if the offering is an underwritten offering, at the
      request of Buyer, use its best efforts to furnish to Buyer on the date
      that securities are delivered to the underwriter(s) for sale pursuant to
      such registration: (x) a copy of an opinion dated such date of counsel
      representing Seller for the purposes of such registration, addressed to
      the underwriter(s), reasonably satisfactory to Buyer and such
      underwriter(s) and (y) a copy of a letter dated such date from the
      independent public accountants retained by Seller, addressed to the
      underwriter(s), reasonably satisfactory to Buyer and such underwriters;

                        (K) make available for inspection by Buyer, any
      underwriter participating in any distribution pursuant to such
      registration statement, and any attorney, accountant or other agent
      retained by Buyer or underwriter, all financial and other records,
      pertinent corporate documents and properties of Seller, and cause Seller's
      officers, directors and employees to supply all information reasonably
      requested by Buyer, or such underwriter, attorney, accountant or agent in
      connection with such registration statement;

                        (L) take all actions reasonably necessary to facilitate
      the timely preparation and delivery of certificates (not bearing any
      legend restricting the resale or transfer of such securities) representing
      the securities to be sold pursuant to the registration statement and to
      enable such certificates to be in such denominations and registered in
      such names as Buyer or any underwriter may reasonably request; and

                        (M) take all other reasonable actions necessary to
      expedite and facilitate the registration of the securities pursuant to the
      registration statement.

                  (iv) Seller shall not grant to any third party any
registration rights materially inconsistent with any of those contained herein,
or that would, in any way, materially adversely affect or limit the registration
rights of Buyer or its permitted assigns without the prior written consent of
Buyer.

            (c) NASDAQ CONSENT.

                  (i) If, as a result of a Conversion Price adjustment pursuant
to Section 3.7 hereof and/or an Exercise Price adjustment pursuant to Section
3.3 of the Warrant Agreement, the Securities could be converted or exercised, as
applicable, into a number of shares of Common Stock in excess of which Seller is
permitted to issue (I.E., nineteen and 99/100 (19.99%) percent of the
then-outstanding shares of Seller's capital stock (the "Nasdaq Threshold"))
under the rules or regulations (the "Trading Regulations") of the NNM, or any
stock exchange or other self-regulatory organization to which Seller or its
securities is subject (collectively, "Nasdaq"), Seller shall (x) promptly
thereupon call and hold a meeting of its

                                       13
<Page>

stockholders in respect thereof and (y) use its best efforts to (A) obtain the
necessary approval of its stockholders, (B) obtain an appropriate order from
Nasdaq that there is an applicable exemption from the Trading Regulations or (C)
obtain a written opinion from Seller's legal counsel that such approval is
otherwise not required, which opinion shall be reasonably satisfactory to Buyer
(each, a "Nasdaq Consent").

                  (ii) If, as a result of the Trading Regulations, Seller may
not issue to Buyer all of the Conversion Shares and/or Warrant Shares to which
Buyer would otherwise be entitled pursuant to this Agreement, the Initial Note
and the Initial Warrant Agreement without first obtaining Nasdaq Consent, Seller
shall, upon request of Buyer, issue to Buyer the maximum number of shares of
Common Stock that Seller may issue without exceeding the Nasdaq Threshold. In no
event shall Buyer exercise or convert any of the Securities or Additional
Securities into a number of shares of Common Stock that would exceed the Nasdaq
Threshold unless and until Seller shall obtain a Nasdaq Consent.

                  (iii) If Seller shall fail to obtain any Nasdaq Consent that
would be required in order for Buyer to receive all of the securities of Seller
to which it would otherwise be entitled hereunder within one hundred and twenty
(120) days following an adjustment in excess of the Nasdaq Threshold (the
"Nasdaq Trigger Date"), then in such event (x) the portion of the principal of,
and any accrued and unpaid interest on, outstanding Note(s) that, if converted
into shares of Common Stock, would be in excess of the Nasdaq Threshold, shall
be immediately due and payable to Buyer by Seller and (y) Buyer shall be
entitled to the additional anti-dilution protection set forth in the following
sentence. If at any time after the Nasdaq Trigger Date, Seller shall issue
Additional Shares of Common Stock (as defined in Section 3.3(1)(D) of the
Warrant Agreement), then in such event, Seller shall issue to Buyer warrants
("Trigger Date Warrants") to purchase additional shares of Common Stock in an
amount equal to twenty (20%) percent of such Additional Shares of Common Stock
(less the number of shares of Common Stock that Buyer shall be entitled to as a
result of any other anti-dilution protection in this Agreement or in the Warrant
Agreements in respect of such issuance) at an exercise price per share equal to
fifty (50%) percent of the Fair Market Value (as defined in the Warrant
Agreement) of such Common Stock at such time, and Seller shall promptly issue
such warrants pursuant to a warrant agreement substantially in the form of the
Warrant Agreement; PROVIDED, HOWEVER, that the obligation of Seller to issue
such warrants pursuant to this Section 6.2(c)(iii) shall terminate at such time
as Buyer shall have received warrants to purchase a number of shares of Common
Stock equal to the number of securities of Seller that Buyer would have been
entitled to but for the Trading Regulations; and PROVIDED, FURTHER, that to the
extent that the issuance of the Trigger Date Warrants shall cause Seller to
issue to Buyer such number of shares of Common Stock that shall exceed the
Nasdaq Threshold, Seller shall have the right to immediately pay any portion of
principal and accrued and unpaid interest on the then-outstanding Note(s) to
reduce the number of shares of Common Stock into which Buyer may convert and/or
exercise without exceeding the Nasdaq Threshold. In the event that any provision
in this Section 6.2(c)(iii) shall conflict with any of the Trading Regulations,
Buyer and Seller shall reasonably negotiate an alternative provision that comes
closest to expressing the intention of such conflicting provision.

                  (iv) If Buyer desires to purchase Additional Securities and
each of the conditions (other than that contained in Section 8.2(a) hereof) to
the purchase and issuance of any Additional Securities has been met (or duly
waived), including, without limitation, the

                                       14
<Page>

achievement of the scheduled milestone on or before the applicable date that
such milestone was to be achieved in accordance with the Milestone Schedule, but
such issuance would require, in accordance with the Trading Regulations,
obtaining Nasdaq Consent, then (x) Seller shall issue, and Buyer shall purchase,
the maximum number of Additional Securities permitted without obtaining such
approval, which Additional Securities shall be allocated between the Notes and
the Warrants as Buyer and Seller shall reasonably agree and (y) Seller shall use
its best efforts to obtain Nasdaq Consent as soon as practicable.

            (d) INTELLECTUAL PROPERTY NOTIFICATION. Seller shall promptly notify
Buyer of any notice or other communication indicating that any of the letters
patent, service marks or trademarks included in the Intellectual Property are
invalid or may become invalid for any reason, including, without limitation,
Seller's failure to make timely payments of all fees and other amounts due to
any governmental authority or any other person in respect of the Intellectual
Property, including any amounts payable in respect of filings, registrations
and/or renewals.

            (e) LIEN PERFECTION. Seller agrees to execute the UCC-1 financing
statements provided for by Law, together with any and all other instruments,
assignments or documents, and shall take such other action as may be required to
perfect or continue the perfection of Buyer's security interest in the
Intellectual Property. Unless prohibited by Law, Seller hereby authorizes Buyer
to execute and file any such financing statement on its behalf.

            (f) NOTICES OF RECORD DATE. If, during any time that any of the
Notes or Warrants is outstanding, Seller shall propose: (i) to declare any
dividend or distribution upon any class or series of capital stock, whether in
cash, property, stock or other securities; (ii) to effect any reclassification
or recapitalization of its Common Stock outstanding involving a change in the
Common Stock; or (iii) to merge or consolidate with or into any other entity, or
to sell, lease or convey all or substantially all of its property or business,
or to liquidate, dissolve or wind up; then, in connection with each such event,
Seller shall mail to Buyer:

                  (x) at least twenty (20) days' prior written notice of the
date on which a record shall be taken for such dividend or distribution (and
specifying the date on which the holders of the affected class or series of
capital stock shall be entitled thereto) or for determining the rights to vote,
if any, in respect of the matters referred to in clauses (ii) and (iii) in this
Section 6.2(f) above; and

                  (y) in the case of the matters referred to in clauses (ii) and
(iii) in this Section 6.2(f), written notice of such impending transaction not
later than twenty (20) days prior to the stockholders' meeting called to approve
such transaction, or twenty (20) days prior to the closing of such transaction,
whichever is earlier, and shall also notify Buyer in writing of the final
approval of such transaction. The first of such notices shall describe the
material terms and conditions of the impending transaction (and specify the date
on which the holders of shares of Common Stock shall be entitled to exchange
their Common Stock for securities or other property deliverable upon the
occurrence of such event) and Seller shall thereafter give Buyer prompt notice
of any material changes. The transaction shall in no event take place sooner
than twenty (20) days after Seller has given the first notice provided for
herein or sooner than ten (10) days after Seller has given notice of any
material changes as provided for herein.

                                       15
<Page>

            (g) FURTHER ASSURANCES; MILESTONE SCHEDULE. Each of the parties
shall execute such documents and other papers and take such further action as
may be reasonably required to carry out the provisions hereof and effectuate the
transactions contemplated hereby, including, but not limited to, obtaining any
consents, waivers or approvals required in connection herewith. As soon as is
reasonably practicable following the Initial Closing Date, Buyer and Seller
shall make reasonable efforts to negotiate and complete the Milestone Schedule,
which shall set forth, among other items, the dates upon which certain
commercial and technical milestones shall be reached by Seller and the rights
and obligations of Buyer and Seller in respect of purchasing and issuing of
Additional Securities at such times.

            7. CONDITIONS PRECEDENT TO THE OBLIGATION OF BUYER TO CLOSE.

            7.1 INITIAL CLOSING. The obligation of Buyer to complete the Initial
Closing is subject to the fulfillment on or prior to the Initial Closing Date of
all of the following conditions, any one or more of which (other than Section
7.1(d) hereof) may be waived by Buyer in writing:

            (a) AGREEMENTS AND CONDITIONS. On or before the Initial Closing
Date, Seller shall have complied with and duly performed and satisfied in all
material respects all agreements and conditions on its part to be complied with
and performed by such date pursuant to this Agreement.

            (b) REPRESENTATIONS AND WARRANTIES. The representations and
warranties of Seller contained in this Agreement shall be true and correct in
all material respects on and as of the Initial Closing Date with the same force
and effect as though such representations and warranties had been made on and as
of such Closing Date.

            (c) NO MATERIAL ADVERSE CHANGE. Since the date of this Agreement,
there shall not have accrued any change, circumstance or event that constitutes
or has resulted in, or that is reasonably likely to result in, a material
adverse change in Buyer's business, assets, operations or financial condition.

            (d) NO LEGAL PROCEEDINGS. No court or governmental action or
proceeding shall have been instituted or threatened to restrain or prohibit the
transactions contemplated hereby.

            (e) CONSENTS. Seller shall have obtained all consents necessary to
effectuate this Agreement and to consummate the transactions contemplated hereby
and delivered copies thereof to Buyer.

            (f) OPINION OF SELLER'S COUNSEL. Buyer shall have received a legal
opinion, dated the applicable Closing Date, of Pillsbury Winthrop LLP, counsel
to Seller, reasonably satisfactory in form and substance to Buyer.

            (g) INITIAL NOTE. Seller shall have duly executed and delivered to
Buyer the Initial Note.

            (h) INTELLECTUAL PROPERTY SECURITY AGREEMENT. Seller shall have duly
executed and delivered to Buyer the Intellectual Property Security Agreement.

                                       16
<Page>

            (i) FINANCING STATEMENTS. Seller shall have duly executed and
delivered to Buyer such UCC-1 financing statements or other documents or
instruments that Buyer reasonably believes are necessary to secure, or evidence
the security on, the Notes.

            (j) INITIAL WARRANT AGREEMENT. Seller shall have duly executed and
delivered to Buyer the Initial Warrant Agreement.

            (k) PAYMENT OF CERTAIN FEES. Buyer shall have received the Expense
Reimbursement (as defined in Section 11.5 hereof).

            7.2 SUBSEQUENT CLOSINGS. The obligation of Buyer to complete any of
the Subsequent Closings is subject to the fulfillment on or prior to the
applicable Subsequent Closing Date of each of the conditions set forth in
Section 7.1 hereof (except subsections (c), (g), (h), (i), (j) and (k) thereof)
and all of the following conditions, any one or more of which (including the
applicable conditions in Section 7.1, except subsection (d) thereof, and Section
7.2(a) below) may be waived by Buyer in writing:

            (a) NASDAQ CONSENT. Buyer shall have received written evidence
reasonably satisfactory to it that Seller shall have obtained any necessary
Nasdaq Consent.

            (b) MILESTONE SCHEDULE. Buyer shall have received written evidence
reasonably satisfactory to it that Seller has achieved the scheduled milestone
on or before the applicable date that such milestone was to be achieved in
accordance with the Milestone Schedule.

            (c) ADDITIONAL NOTES. Seller shall have duly executed and delivered
the appropriate Additional Note.

            (d) ADDITIONAL WARRANT AGREEMENTS. Seller shall have duly executed
and delivered the appropriate Additional Warrant Agreement.

            8. CONDITIONS PRECEDENT TO THE OBLIGATION OF SELLER TO CLOSE.

            8.1 INITIAL CLOSING. The obligation of Seller to complete the
Initial Closing is subject to the fulfillment on or prior to the Initial Closing
Date of all of the following conditions, any one or more of which (other than
Section 8.1(c) hereof) may be waived by Seller in writing:

            (a) AGREEMENTS AND CONDITIONS. On or before the Initial Closing
Date, Buyer shall have complied with and performed and satisfied in all material
respects all agreements and conditions on its part to be complied with and
performed by such date pursuant to this Agreement.

            (b) REPRESENTATIONS AND WARRANTIES. The representations and
warranties of Buyer contained in this Agreement shall be true and correct in all
material respects on and as of the Initial Closing Date with the same force and
effect as though such representations and warranties had been made on and as of
the Closing Date.

                                       17
<Page>

            (c) NO LEGAL PROCEEDINGS. No court or governmental action or
proceeding shall have been instituted or threatened to restrain or prohibit the
transactions contemplated hereby.

            (d) INITIAL WARRANT AGREEMENT. Buyer shall have duly executed and
delivered to Seller the Initial Warrant Agreement.

            (e) PAYMENT OF PURCHASE PRICE. Buyer shall have paid to Seller the
Purchase Price.

            8.2 SUBSEQUENT CLOSINGS. The obligation of Seller to complete any
Subsequent Closing is subject to the fulfillment on or prior to the applicable
Subsequent Closing Date of each of the conditions set forth in Section 8.1
hereof and all of the following conditions, any one or more of which (including
the conditions in Section 8.1, except subsection (c) thereof, and Section 8.2(a)
below) may be waived by Seller in writing:

            (a) NASDAQ CONSENT. Seller shall have received written evidence
reasonably satisfactory to it that any necessary Nasdaq Consent shall have been
obtained.

            (b) ADDITIONAL WARRANT AGREEMENTS. Buyer shall have duly executed
the appropriate Additional Warrant Agreement.

            (c) PAYMENT OF ADDITIONAL PURCHASE PRICE. Buyer shall have paid to
Seller the appropriate Additional Purchase Price

            9. EVENTS OF DEFAULT. If any of the following events (each, an
"Event of Default") shall occur and be continuing:

            (i) Seller shall fail to pay any principal of any of the Notes,
within three (3) business days after such principal payment becomes due in
accordance with the terms thereof or hereof; or Seller shall fail to pay any
interest on any of the Notes or any other amount payable thereunder, within five
(5) business days after any such interest or other amount becomes due in
accordance with the terms thereof or hereof;

            (ii) Any representation or warranty made or deemed made by Seller
herein or in any other agreement, certificate or instrument contemplated by this
Agreement or that is contained in any certificate, document or financial or
other statement furnished by Seller at any time under or in connection with this
Agreement shall have been incorrect in any material respect on or as of the date
made or deemed made;

            (iii) Seller shall default, in any material respect, in the
observance or performance of any other agreement contained in this Agreement or
any other agreement or instrument contemplated by this Agreement (including the
Warrant Agreements and the Intellectual Property Security Agreement), and such
default shall continue unremedied for a period of ten (10) days after written
notice to Seller of such default; or

            (iv) (a) Seller shall commence any case, proceeding or other action
(x) under any existing or future law of any jurisdiction, domestic or foreign,
relating to bankruptcy,

                                       18
<Page>

insolvency, reorganization, conservatorship or relief of debtors, seeking to
have an order for relief entered with respect to it, or seeking to adjudicate it
a bankrupt or insolvent, or seeking reorganization, arrangement, adjustment,
winding-up, liquidation, dissolution, composition or other relief with respect
to it or its debts or (y) seeking appointment of a receiver, trustee, custodian,
conservator or other similar official for it or for all or any substantial part
of its assets, or Seller shall make a general assignment for the benefit of its
creditors; or (b) there shall be commenced against Seller any case, proceeding
or other action of a nature referred to in clause (a) above that (A) results in
the entry of an order for relief of any such adjudication or appointment or (B)
remains undismissed, undischarged or unbonded for a period of sixty (60) days;
or (c) there shall be commenced against Seller any case, proceeding or other
action seeking issuance of a warrant of attachment, execution, distrait or
similar process against all or any substantial part of its assets that results
in the entry of an order for any such relief that shall not have been vacated,
discharged, or stayed or bonded pending appeal within sixty (60) days from the
entry thereof; or (d) Seller shall take any action in furtherance of, or
indicating its consent to, approval of, or acquiescence in, any of the acts set
forth in clauses (a), (b) or (c) above; or (e) Seller shall generally not, or
shall be unable to, or shall admit in writing its inability to, pay its debts as
they become due,

            then, and in any such event, (x) if such event is an Event of
Default specified in clause (iv) above of this Section 9 with respect to Seller,
all of the Notes (with all accrued and unpaid interest thereon) and all other
amounts owing under this Agreement and any of the Notes shall automatically and
immediately become due and payable and (y) if such event is any other Event of
Default, Buyer may, by written notice to Seller, immediately declare all of the
Notes (with all accrued and unpaid interest thereon) and all other amounts owing
under this Agreement and any of the Notes to be due and payable forthwith,
whereupon the same shall immediately become due and payable. Except as expressly
provided above in this Section 9, presentation, demand, protest and all other
notices of any kind are hereby expressly waived by Seller.

            10. TERMINATION. This Agreement may be terminated prior to the
Initial Closing Date:

            (a)   at any time by the mutual consent in writing of the parties
                  hereto;

            (b)   by Seller or Buyer in writing if the Initial Closing shall not
                  have occurred by November 15, 2001, but only if the Initial
                  Closing shall not have occurred for a reason other than the
                  breach by such terminating party of any of its
                  representations, warranties, covenants or agreements contained
                  herein;

            (c)   at any time by Buyer in writing upon a material breach of any
                  of the representations, warranties, covenants or agreements of
                  Seller contained in this Agreement; or

            (d)   at any time by Seller in writing upon a material breach of any
                  of the representations, warranties, covenants or agreements of
                  Buyer contained in this Agreement.

                                       19
<Page>

            In the event of termination of this Agreement by Seller or Buyer
prior to the Initial Closing as set forth above, this Agreement shall forthwith
terminate and there shall be no liability on the part of Seller or Buyer;
PROVIDED, HOWEVER, that no party shall be relieved of any loss, damage or
liability occurring or sustained as a result of a termination following such
party's material breach of any representation, warranty, covenant or agreement
contained in this Agreement. Notwithstanding any termination of this Agreement,
the provisions of this Section 10 and Section 11 hereof shall survive.

            11. MISCELLANEOUS.

            11.1 PUBLICITY. The parties may issue a public announcement
following the Initial Closing in form and content reasonably satisfactory to
each of the parties hereto.

            11.2 NOTICES. All notices and other communications hereunder shall
be in writing and shall be deemed to have been given when delivered by hand or
by facsimile transmission, when telexed, or upon receipt when mailed by
registered or certified mail (return receipt requested), postage prepaid, to the
parties at the following addresses (or at such other address for a party as
shall be specified by like notice):

            (i)   If to Seller:

                  The Immune Response Corporation
                  5935 Darwin Court
                  Carlsbad, CA 92008
                  Attention: President
                  Facsimile: (760) 431-8636

                  With a copy (which copy shall not constitute notice) to:

                  Pillsbury Winthrop LLP
                  50 Fremont Street
                  San Francisco, CA 94105
                  Attention: Thomas E. Sparks, Esq.
                  Facsimile: (415) 983-7396

            (ii)  If to Buyer:

                  Kevin Kimberlin Partners, L.P.
                  535 Madison Avenue
                  New York, NY 10022
                  Attention: Kevin Kimberlin and Bruno Lerer, Esq.
                  Facsimile: (212) 486-7392

                  With a copy (which copy shall not constitute notice) to:

                  Kirkpatrick & Lockhart LLP
                  1251 Avenue of the Americas, 45th Floor

                                       20
<Page>

                  New York, NY 10020-1104
                  Attention: Stephen R. Connoni, Esq.
                  Facsimile: (212) 536-3901

            11.3 ENTIRE AGREEMENT. This Agreement (including the Schedules
hereto) and the certificates executed in connection with the consummation of the
transactions contemplated hereby embody the entire agreement and understanding
of the parties hereto with respect to the subject matter hereof.

            11.4 GOVERNING LAW. This Agreement shall be governed by and
construed in accordance with the internal laws of the State of New York
applicable to agreements made and to be performed entirely within such
jurisdiction.

            11.5 EXPENSES. Seller and Buyer shall, subject to the immediately
succeeding sentence, bear their respective expenses incurred in connection with
the negotiation, preparation, execution and performance of this Agreement, the
Notes, the Warrants and the Intellectual Property Security Agreement and the
consummation of the transactions contemplated hereby and thereby, including,
without limitation, all fees and expenses of agents, representatives, counsel,
brokers or finders and accountants. Notwithstanding the preceding sentence,
Seller shall reimburse Buyer at the Initial Closing for all legal expenses and
costs incurred by Buyer in connection with the negotiation, preparation and
execution of this Agreement and the other agreements contemplated hereby (the
"Expense Reimbursement") in an amount equal to $35,000. The Expense
Reimbursement shall be deducted from the Purchase Price or paid by Seller
separately, as Seller and Buyer shall agree.

            11.6 TRANSFERABILITY. Subject to securities laws restrictions of
general applicability, this Agreement, the Notes, the Intellectual Property
Security Agreement and the Warrant Agreements (collectively, the "Loan
Documents") and all rights hereunder and thereunder are freely and separately
transferable and assignable, in whole or in part, by Buyer, directly or
indirectly, to any of its affiliates (the "Permitted Transferees"). Neither
Buyer nor any of the Permitted Transferees shall (i) transfer any of the Loan
Documents to any person or entity known by Buyer to be a competitor of Seller or
(ii) assign less than twenty-five (25%) percent of any of the Notes to any
person or entity (other than a Permitted Transferee), except as expressly
provided herein or with the prior written consent of Seller, which consent shall
not be unreasonably withheld. The foregoing permitted transferees and assignees
shall be entitled to the rights provided in the Loan Documents. Notwithstanding
the foregoing, in the event of an assignment or transfer of any of the Loan
Documents to a person or entity other than a Permitted Transferee, Buyer shall
act as collateral agent in respect of the Intellectual Property Security
Agreement and prior to such assignment or transfer, Seller, Buyer and the
transferee shall enter into a Collateral Agent Agreement on reasonable terms to
be agreed upon among the parties at such time. Seller may not assign or delegate
any of its obligations under the Loan Documents without the prior written
consent of Buyer (or its successor or permitted transferee or assignee). For
purposes hereof, a sale or exchange by Seller of all or substantially all of its
assets shall constitute an assignment/delegation requiring Buyer's prior written
consent.

                            [SIGNATURE PAGE FOLLOWS]

                                       21
<Page>

      IN WITNESS WHEREOF, the parties hereto have executed this Note Purchase
Agreement on the date first above written.

                                       KEVIN KIMBERLIN PARTNERS, L.P.
                                       by KKP Management LLC,
                                          General Partner

                                       By: /s/ Kevin Kimberlin
                                          ---------------------------------
                                          Name:  Kevin Kimberlin
                                          Title: Member Manager

                                       THE IMMUNE RESPONSE CORPORATION

                                       By: /s/ Howard Sampson
                                          ---------------------------------
                                          Name:  Howard Sampson
                                          Title: VP, Finance
                                                 CFO, Treasurer

                                       22
<Page>

                                    EXHIBIT A

                       Convertible Secured Promissory Note

<Page>

                                    EXHIBIT B

                                Warrant Agreement

<Page>

                                    EXHIBIT C

                    Intellectual Property Security Agreement

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