Document:

Exhibit 10.1

 

SECURITIES
PURCHASE AGREEMENT

 

This Securities Purchase
Agreement (this “Agreement”) is dated as of March 28, 2019, between Therapix Biosciences Ltd., an Israeli corporation
(the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors
and assigns, a “Purchaser” and collectively the “Purchasers”).

 

WHEREAS, subject to
the terms and conditions set forth in this Agreement and pursuant to (i) an effective registration statement under the Securities
Act of 1933, as amended (the “Securities Act”), as to the Shares and (ii) an exemption from the registration
requirements of Section 5 of the Securities Act contained in Section 4(a)(2) thereof and/or Regulation D thereunder as to the Warrants,
the Company desires to issue and sell to each Purchaser, and each Purchaser, severally and not jointly, desires to purchase from
the Company, securities of the Company as more fully described in this Agreement.

 

NOW, THEREFORE, IN
CONSIDERATION of the mutual covenants contained in this Agreement, and for other good and valuable consideration the receipt and
adequacy of which are hereby acknowledged, the Company and each Purchaser agree as follows:

 

ARTICLE I.

DEFINITIONS

 

1.1 Definitions.
In addition to the terms defined elsewhere in this Agreement, for all purposes of this Agreement, the following terms have the
meanings set forth in this Section 1.1:

 

“Acquiring
Person” shall have the meaning ascribed to such term in Section 4.4.

 

“Action”
shall have the meaning ascribed to such term in Section 3.1(j).

 

“ADS
Registration Statement” shall have the meaning ascribed to such term in Section 3.1(f).

 

“ADSs”
means the American Depositary Shares of the Company, each representing forty (40) Ordinary Shares.

 

“Affiliate”
means any Person that, directly or indirectly through one or more intermediaries, controls or is controlled by or is under common
control with a Person as such terms are used in and construed under Rule 405 under the Securities Act.

 

“Board
of Directors” means the board of directors of the Company.

 

“Business
Day” means any day except any Saturday, any Sunday, any day which is a federal legal holiday in the United States, a
legal holiday in the State of Israel, or any day on which banking institutions in the State of New York or the State of Israel
are authorized or required by law or other governmental action to close.

 

“Closing”
means the closing of the purchase and sale of the Securities pursuant to Section 2.1.

 

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“Closing
Date” means the Trading Day on which all of the Transaction Documents have been executed and delivered by the applicable
parties thereto, and all conditions precedent to (i) the Purchasers’ obligations to pay the Subscription Amount and (ii)
the Company’s obligations to deliver the Securities, in each case, have been satisfied or waived, but in no event later than
the second (2nd) Trading Day following the date hereof, unless the banking institutions in the State of Israel are closed
on such Trading Day in which case the Securities shall be delivered on the third (3rd) Trading Day following the date
hereof.

 

“Commission”
means the United States Securities and Exchange Commission.

 

“Company
Counsel” means Zysman, Aharoni, Gayer and Sullivan & Worcester LLP, with offices located at 1633 Broadway, New York,
New York 10119.

 

“Company
Israeli Counsel” means Horn and Co. Law Office with offices located at 2 Weizmann St., Tel-Aviv, Israel 6423902.

 

“Deposit
Agreement” means the Amended and Restated Deposit Agreement dated as of March 21, 2017, among the Company, The Bank of
New York Mellon as Depositary and the owners and holders of ADSs from time to time, as such agreement may be amended or supplemented.

 

“Depositary”
means The Bank of New York Mellon, as Depositary under the Deposit Agreement.

 

“Disclosure
Schedules” means the Disclosure Schedules of the Company delivered concurrently herewith.

 

“Disclosure
Time” means, (i) if this Agreement is signed on any day that is not a Trading Day or after 9:00 a.m. (New York City time)
and before midnight (New York City time) on any Trading Day, 9:01 a.m. (New York City time) on the Trading Day immediately following
the date hereof (ii) if this Agreement is signed between midnight (New York City time) and 9:00 a.m. (New York City time) on any
Trading Day, no later than 9:01 a.m. (New York City time) on the date hereof.

 

“Disqualification
Event” shall have the meaning ascribed to such term in Section 3.1(oo).

 

“DVP”
shall have the meaning ascribed to such term in Section 2.1.

 

“Environmental
Laws” shall have the meaning ascribed to such term in Section 3.1(m).

 

“Evaluation
Date” shall have the meaning ascribed to such term in Section 3.1(s).

 

“Exchange
Act” means the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder.

 

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“Exempt
Issuance” means the issuance of (a) shares of Common Stock, ADSs or options to employees, officers or directors of the
Company pursuant to any stock or option plan duly adopted for such purpose, which issuance was approved by a majority of the non-employee
members of the Board of Directors or a majority of the members of a committee of non-employee directors established for such purpose,
for services rendered to the Company (b) securities upon the exercise or exchange of or conversion of any Securities issued hereunder
and/or other securities exercisable or exchangeable for or convertible into ADSs or shares of Common Stock issued and outstanding
on the date of this Agreement, provided that such securities have not been amended since the date of this Agreement to increase
the number of such securities or to decrease the exercise price, exchange price or conversion price of such securities (other than
in connection with stock splits or combinations) or to extend the term of such securities and (c) securities issued pursuant to
acquisitions or strategic transactions approved by a majority of the disinterested directors of the Company, provided that such
securities are issued as “restricted securities” (as defined in Rule 144) and carry no registration rights that require
or permit the filing of any registration statement in connection therewith during the prohibition period in Section 4.11 herein,
and provided that any such issuance shall only be to a Person (or to the equityholders of a Person) which is, itself or through
its subsidiaries, an operating company or an owner of an asset in a business synergistic with the business of the Company and shall
provide to the Company additional benefits in addition to the investment of funds, but shall not include a transaction in which
the Company is issuing securities primarily for the purpose of raising capital or to an entity whose primary business is investing
in securities.

 

“FCPA”
means the Foreign Corrupt Practices Act of 1977, as amended.

 

“FDA”
shall have the meaning ascribed to such term in Section 3.1(hh).

 

“FDCA”
shall have the meaning ascribed to such term in Section 3.1(hh).

 

“Federal
Reserve” shall have the meaning ascribed to such term in Section 3.1(kk).

 

“IFRS”
shall have the meaning ascribed to such term in Section 3.1(h).

 

“Hazardous
Materials” shall have the meaning ascribed to such term in Section 3.1(m).

 

“Indebtedness”
shall have the meaning ascribed to such term in Section 3.1(aa).

 

“Intellectual
Property Rights” shall have the meaning ascribed to such term in Section 3.1(p).

 

“Israeli
Securities Laws” means the Securities Law, the rules and regulations promulgated under the Securities Law and any rules
and regulations of the Tel Aviv Stock Exchange.

 

“Issuer
Covered Person” shall have the meaning ascribed to such term in Section 3.1(oo).

 

“Legend
Removal Date” shall have the meaning ascribed to such term in Section 4.1(d).

 

“Liens”
means a lien, charge, pledge, security interest, encumbrance, right of first refusal, preemptive right or other restriction.

 

“Material
Adverse Effect” shall have the meaning assigned to such term in Section 3.1(b).

 

“Material
Permits” shall have the meaning ascribed to such term in Section 3.1(n).

 

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“Money
Laundering Laws” shall have the meaning ascribed to such term in Section 3.1(ll).

 

“Ordinary
Share(s)” means the ordinary shares of the Company, no par value per share, and any other class of securities into which
such securities may hereafter be reclassified or changed.

 

“Ordinary
Share Equivalents” means any securities of the Company or the Subsidiaries which would entitle the holder thereof to
acquire at any time ADSs or Ordinary Shares, including, without limitation, any debt, preferred stock, right, option, warrant or
other instrument that is at any time convertible into or exercisable or exchangeable for, or otherwise entitles the holder thereof
to receive, ADSs or Ordinary Shares.

 

“Per
Share Purchase Price” equals $3.50, inclusive of the Depositary ADS issuance fee of $0.02, subject to adjustment for
reverse and forward stock splits, stock dividends, stock combinations and other similar transactions of the Ordinary Shares or
ADSs that occur after the date of this Agreement.

 

“Person”
means an individual or corporation, partnership, trust, incorporated or unincorporated association, joint venture, limited liability
company, joint stock company, government (or an agency or subdivision thereof) or other entity of any kind.

 

“Pharmaceutical
Product” shall have the meaning ascribed to such term in Section 3.1(hh).

 

“Proceeding”
means an action, claim, suit, investigation or proceeding (including, without limitation, an informal investigation or partial
proceeding, such as a deposition), whether commenced or threatened.

 

“Prospectus”
means the final base prospectus filed for the Registration Statement.

 

“Prospectus
Supplement” means the supplement to the Prospectus complying with Rule 424(b) of the Securities Act that is filed with
the Commission and delivered by the Company to each Purchaser at the Closing.

 

“Public
Information Failure” shall have the meaning ascribed to such term in Section 4.2(b).

 

“Purchaser
Party” shall have the meaning ascribed to such term in Section 4.8.

 

“Qualified
Investor” shall have the meaning ascribed to such term in Section 2.2(b)(iii).

 

“Registration
Statement” means the effective registration statement on Form F-3 with Commission File No. 333-225745 which registers
the sale of the Shares to the Purchasers.

 

“Required
Approvals” shall have the meaning ascribed to such term in Section 3.1(e).

 

“Rule
144” means Rule 144 promulgated by the Commission pursuant to the Securities Act, as such Rule may be amended or interpreted
from time to time, or any similar rule or regulation hereafter adopted by the Commission having substantially the same purpose
and effect as such Rule.

 

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“Rule
424” means Rule 424 promulgated by the Commission pursuant to the Securities Act, as such Rule may be amended or interpreted
from time to time, or any similar rule or regulation hereafter adopted by the Commission having substantially the same purpose
and effect as such Rule.

 

“SEC
Reports” shall have the meaning ascribed to such term in Section 3.1(h).

 

“Securities”
means the Shares, the Warrants and the Warrant Shares.

 

“Securities
Law” means the Israeli Securities Law. 5728-1968.

 

“Shares”
means the ADS issued or issuable to each Purchaser pursuant to this Agreement.

 

“Short
Sales” means all “short sales” as defined in Rule 200 of Regulation SHO under the Exchange Act (but shall
not be deemed to include the locating and borrowing of ADSs or shares of Ordinary Shares).

 

“Standard
Settlement Period” shall have the meaning ascribed to such term in Section 4.1(d).

 

“Subscription
Amount” means, as to each Purchaser, the aggregate amount to be paid for Shares and Warrants purchased hereunder, including
the applicable Depositary’s fee of US$0.02 per ADS for issuance of ADSs, as specified below such Purchaser’s name on
the signature page of this Agreement and next to the heading “Subscription Amount,” in United States dollars and in
immediately available funds.

 

“Subsidiary”
means any subsidiary of the Company as set forth on Schedule 3.1(a), and shall, where applicable, also include any direct or indirect
subsidiary of the Company formed or acquired after the date hereof.

 

“Trading
Day” means a day on which the principal Trading Market is open for trading.

 

“Trading
Market” means any of the following markets or exchanges on which the ADSs are listed or quoted for trading on the date
in question: the NYSE American, the Nasdaq Capital Market, the Nasdaq Global Market, the Nasdaq Global Select Market, or the New
York Stock Exchange (or any successors to any of the foregoing).

 

“Transaction
Documents” means this Agreement, the Warrants, all exhibits and schedules thereto and hereto and any other documents
or agreements executed in connection with the transactions contemplated hereunder.

 

“VWAP”
means, for any date, the price determined by the first of the following clauses that applies: (a) if the ADSs are then listed or
quoted on a Trading Market, the daily volume weighted average price of the ADSs for such date (or the nearest preceding date) on
the Trading Market on which the ADSs are then listed or quoted as reported by Bloomberg L.P. (based on a Trading Day from 9:30
a.m. (New York City time) to 4:02 p.m. (New York City time)), (b)  if OTCQB or OTCQX is not a Trading Market, the volume weighted
average price of the ADSs for such date (or the nearest preceding date) on OTCQB or OTCQX as applicable, (c) if the ADSs are not
then listed or quoted for trading on OTCQB or OTCQX and if prices for the ADSs are then reported in the “Pink Sheets”
published by OTC Markets Group, Inc. (or a similar organization or agency succeeding to its functions of reporting prices), the
most recent bid price per ADS so reported, or (d) in all other cases, the fair market value of an ADS as determined by an
independent appraiser selected in good faith by the Holders of a majority in interest of the Securities then outstanding and reasonably
acceptable to the Company, the fees and expenses of which shall be paid by the Company.

 

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“Warrants”
means, collectively, the ADS purchase warrants delivered to the Purchasers at the Closing in accordance with Section 2.2(a) hereof,
which Warrants shall be exercisable immediately and have a term of exercise equal to three years following the initial exercise
date, in the form of Exhibit A attached hereto.

 

“Warrant
ADSs” means the ADSs representing Warrant Shares.

 

“Warrant
Shares” means the Ordinary Shares underlying the ADSs issuable upon exercise of the Warrants.

 

ARTICLE II.

PURCHASE AND SALE

 

2.1 Closing.
On the Closing Date, upon the terms and subject to the conditions set forth herein, the Company agrees to sell, and the Purchasers,
severally and not jointly, agree to purchase, up to an aggregate of approximately $2.5 million of Shares and Warrants. Each Purchaser’s
Subscription Amount, as set forth on the signature page hereto executed by such Purchaser shall be made available for “Delivery
Versus Payment” (“DVP”) settlement with the Company. The Company shall deposit the Ordinary Shares and
instruct the Depositary to deliver to each Purchaser its respective ADSs and Warrants as determined pursuant to Section 2.2(a),
and the Company and each Purchaser shall deliver the other items set forth in Section 2.2 deliverable at the Closing. Upon satisfaction
of the covenants and conditions set forth in Sections 2.2 and 2.3, the Closing shall occur at the offices of the Company Counsel
or such other location as the parties shall mutually agree. Unless otherwise directed by the Purchasers settlement of the ADSs
shall occur via “DVP (i.e., on the Closing Date, the Company shall cause the Depositary to issue the ADSs registered in the
Purchasers’ names and addresses and released by the Depositary directly to the account(s) identified by each Purchaser; upon
receipt of such ADSs, payment therefor shall be made by the Purchaser (or its clearing firm) by wire transfer to the Company.

 

2.2 Deliveries.

 

(a) On or
prior to the Closing Date, the Company shall deliver or cause to be delivered to each Purchaser the following:

 

(i) this Agreement
duly executed by the Company;

 

(ii) subject
to the last sentence of Section 2.1, contemporaneously with the Closing, a number of ADSs equal to such Purchaser’s Subscription
Amount divided by the Per Share Purchase Price via The Depository Trust Company Deposit or Withdrawal at Custodian system per the
instructions of such Purchaser set forth on such Purchaser’s signature page hereto;

 

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(iii) a Warrant
registered in the name of such Purchaser to purchase up to a number of ADSs equal to 75% of such Purchaser’s ADSs, with an
exercise price equal to $3.50 per ADS, subject to adjustment therein;

 

(iv) a 90-day
lock-up agreement (the “Lock-Up Agreements”) from each of the Company’s directors and officers, in a form
reasonably acceptable to the Purchasers;

 

(v) with respect
to purchasers in the United States of America, the Prospectus and Prospectus Supplement (which may be delivered in accordance with
Rule 172 under the Securities Act); and

 

(vi) a certificate,
directed to the Purchasers, of the chief financial officer of the Company with respect to certain financial information reasonably
acceptable to the Purchasers.

 

(b) On or
prior to the Closing Date, each Purchaser shall deliver or cause to be delivered to the Company the following:

 

(i) this Agreement
duly executed by such Purchaser;

 

(ii) via the
clearing firm pursuant to the last sentence of Section 2.1, such Purchaser’s Subscription Amount, which shall be made available
for DVP settlement with the Company; and

 

(iii) with
respect to Purchasers in the State of Israel, written confirmation that as of the date of any offer of securities, and as of the
Closing Date, they fall within the scope of one of the criteria of qualified investor pursuant to the First Addendum of the Securities
Law (“Qualified Investor”), that they are fully aware of the significance of being a Qualified Investor pursuant
to such criteria and that they have given their consent, in form and substance reasonably satisfactory in all respects to the Company.

 

2.3 Closing Conditions.

 

(a) The obligations
of the Company hereunder in connection with the Closing are subject to the following conditions being met:

 

(i) the accuracy
in all material respects (or, to the extent representations or warranties are qualified by materiality or Material Adverse Effect,
in all respects) on the Closing Date of the representations and warranties of the Purchasers contained herein (unless as of a specific
date therein in which case they shall be accurate as of such date);

 

(ii) all obligations,
covenants and agreements of each Purchaser required to be performed at or prior to the Closing Date shall have been performed;
and

 

(iii) the delivery
by each Purchaser of the items set forth in Section 2.2(b) of this Agreement.

 

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(b) The respective
obligations of the Purchasers hereunder in connection with the Closing are subject to the following conditions being met:

 

(i) the accuracy
in all material respects (or, to the extent representations or warranties are qualified by materiality or Material Adverse Effect,
in all respects) when made and on the Closing Date of the representations and warranties of the Company contained herein (unless
as of a specific date therein in which case they shall be accurate as of such date);

 

(ii) all obligations,
covenants and agreements of the Company required to be performed at or prior to the Closing Date shall have been performed;

 

(iii) the delivery
by the Company of the items set forth in Section 2.2(a) of this Agreement;

 

(iv) there
shall have been no Material Adverse Effect with respect to the Company since the date hereof; and

 

(v) from the
date hereof to the Closing Date, trading in the ADSs shall not have been suspended by the Commission or the Company’s principal
Trading Market, and, at any time prior to the Closing Date, trading in securities generally as reported by Bloomberg L.P. shall
not have been suspended or limited, or minimum prices shall not have been established on securities whose trades are reported by
such service, or on any Trading Market, nor shall a banking moratorium have been declared either by the United States or New York
State authorities nor shall there have occurred any material outbreak or escalation of hostilities or other national or international
calamity of such magnitude in its effect on, or any material adverse change in, any financial market which, in each case, in the
reasonable judgment of such Purchaser, makes it impracticable or inadvisable to purchase the Securities at the Closing.

 

ARTICLE III.

REPRESENTATIONS AND WARRANTIES

 

3.1 Representations
and Warranties of the Company. Except as set forth in the Disclosure Schedules, which Disclosure Schedules shall be deemed
a part hereof and shall qualify any representation or otherwise made herein to the extent of the disclosure contained in the corresponding
section of the Disclosure Schedules, the Company hereby makes the following representations and warranties to each Purchaser:

 

(a) Subsidiaries.
All of the direct and indirect subsidiaries of the Company are set forth in Schedule 3.1(a). Except as set forth on Schedule 3.1(a),
the Company owns, directly or indirectly, all of the capital stock or other equity interests of each Subsidiary free and clear
of any Liens, and all of the issued and outstanding shares of capital stock of each Subsidiary are validly issued and are fully
paid, non-assessable and free of preemptive and similar rights to subscribe for or purchase securities.

 

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(b) Organization
and Qualification. The Company and each of the Subsidiaries is an entity duly incorporated or otherwise organized, validly
existing and in good standing under the laws of the jurisdiction of its incorporation or organization (if the concept of good standing
exists in such jurisdiction), with the requisite power and authority to own and use its properties and assets and to carry on its
business as described in the SEC Reports. Neither the Company nor any Subsidiary is in violation nor default of any of the provisions
of its respective certificate or articles of incorporation, bylaws or other organizational or charter documents. Each of the Company
and the Subsidiaries is duly qualified to conduct business and is in good standing as a foreign corporation or other entity in
each jurisdiction in which the nature of the business conducted or property owned by it makes such qualification necessary, except
where the failure to be so qualified or in good standing, as the case may be, could not have or reasonably be expected to result
in: (i) a material adverse effect on the legality, validity or enforceability of any Transaction Document, (ii) a material adverse
effect on the results of operations, assets, business, prospects or condition (financial or otherwise) of the Company and the Subsidiaries,
taken as a whole, or (iii) a material adverse effect on the Company’s ability to perform in any material respect on a timely
basis its obligations under any Transaction Document (any of (i), (ii) or (iii), a “Material Adverse Effect”)
and no Proceeding has been instituted in any such jurisdiction revoking, limiting or curtailing or seeking to revoke, limit or
curtail such power and authority or qualification.

 

(c) Authorization;
Enforcement. The Company has the requisite corporate power and authority to enter into and to consummate the transactions contemplated
by this Agreement and each of the other Transaction Documents and otherwise to carry out its obligations hereunder and thereunder.
The execution and delivery of this Agreement and each of the other Transaction Documents by the Company and the consummation by
it of the transactions contemplated hereby and thereby have been duly authorized by all necessary action on the part of the Company
and no further action is required by the Company, the Board of Directors or the Company’s stockholders in connection herewith
or therewith other than in connection with the Required Approvals. This Agreement and each other Transaction Document to which
it is a party has been (or upon delivery will have been) duly executed by the Company and, when delivered in accordance with the
terms hereof and thereof, will constitute the valid and binding obligation of the Company enforceable against the Company in accordance
with its terms, except (i) as limited by general equitable principles and applicable bankruptcy, insolvency, reorganization, moratorium
and other laws of general application affecting enforcement of creditors’ rights generally, (ii) as limited by laws relating
to the availability of specific performance, injunctive relief or other equitable remedies and (iii) insofar as indemnification
and contribution provisions may be limited by applicable law.

 

(d) No
Conflicts. The execution, delivery and performance by the Company of this Agreement and the other Transaction Documents to
which it is a party, the issuance and sale of the Securities and the consummation by it of the transactions contemplated hereby
and thereby do not and will not (i) conflict with or violate any provision of the Company’s or any Subsidiary’s certificate
or articles of incorporation, bylaws or other organizational or charter documents, or (ii) conflict with, or constitute a default
(or an event that with notice or lapse of time or both would become a default) under, result in the creation of any Lien upon any
of the properties or assets of the Company or any Subsidiary, or give to others any rights of termination, amendment, anti-dilution
or similar adjustments, acceleration or cancellation (with or without notice, lapse of time or both) of, any agreement, credit
facility, debt or other instrument (evidencing a Company or Subsidiary debt or otherwise) or other understanding to which the Company
or any Subsidiary is a party or by which any property or asset of the Company or any Subsidiary is bound or affected, or (iii)
subject to the Required Approvals, conflict with or result in a violation of any law, rule, regulation, order, judgment, injunction,
decree or other restriction of any court or governmental authority to which the Company or a Subsidiary is subject (including federal
and state securities laws and regulations), or by which any property or asset of the Company or a Subsidiary is bound or affected;
except in the case of each of clauses (ii) and (iii), such as could not have or reasonably be expected to result in a Material
Adverse Effect.

 

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(e) Filings,
Consents and Approvals. The Company is not required to obtain any consent, waiver, authorization or order of, give any notice
to, or make any filing or registration with, any court or other federal, state, local or other governmental authority or other
Person in connection with the execution, delivery and performance by the Company of the Transaction Documents, other than: (i)
the filings required pursuant to Section 4.4 of this Agreement, (ii) the filing with the Commission of the Prospectus Supplement,
(iii) application(s) to each applicable Trading Market for the listing of the ADSs and the ADSs issuable upon the exercise of the
Warrants for trading thereon in the time and manner required thereby, and (iv) the filing of a Form D with the Commission and such
filings are required to be made under applicable state securities laws relating to the Warrants (collectively, the “Required
Approvals”).

 

(f) Issuance
of the Securities; Registration. The Shares and Warrants are duly authorized and, when issued and paid for in accordance with
the applicable Transaction Documents, will be duly and validly issued, fully paid and nonassessable, free and clear of all Liens
imposed by the Company other than restrictions on transfer provided for in this Agreement and the Warrants. The Warrant Shares,
when issued in accordance with the terms of the Warrants, will be validly issued, fully paid and nonassessable, free and clear
of all Liens imposed by the Company other than restrictions on transfer provided for in this Agreement and the Warrants. The Company
has reserved from its duly authorized capital stock the maximum number of shares of Ordinary Shares underlying the ADSs issuable
pursuant to this Agreement and the Warrants. The Company has prepared and filed the Registration Statement in conformity with the
requirements of the Securities Act, which became effective on July 20, 2018 (the “Effective Date”), including
the Prospectus, and such amendments and supplements thereto as may have been required to the date of this Agreement. The Registration
Statement and the ADS Registration Statement (as defined below) are effective under the Securities Act and no stop order preventing
or suspending the effectiveness of the Registration Statement or suspending or preventing the use of the Prospectus has been issued
by the Commission and no proceedings for that purpose have been instituted or, to the knowledge of the Company, are threatened
by the Commission. The Company, if required by the rules and regulations of the Commission, shall file the Prospectus with the
Commission pursuant to Rule 424(b). At the time the Registration Statement and the ADS Registration Statement and any amendments
thereto became effective, at the date of this Agreement and at the Closing Date, the Registration Statement and the ADS Registration
Statement and any amendments thereto conformed and will conform in all material respects to the requirements of the Securities
Act and did not and will not contain any untrue statement of a material fact or omit to state any material fact required to be
stated therein or necessary to make the statements therein not misleading; and the Prospectus and any amendments or supplements
thereto, at time the Prospectus or any amendment or supplement thereto was issued and at the Closing Date, conformed and will conform
in all material respects to the requirements of the Securities Act and did not and will not contain an untrue statement of a material
fact or omit to state a material fact necessary in order to make the statements therein, in light of the circumstances under which
they were made, not misleading. The Company and the Depositary have prepared and filed with the Commission a registration statement
relating to ADSs on Form F-6 (File No. 333-197509) for registration under the Securities Act (the “ADS Registration Statement”)
which was declared effective on July 31, 2014. The Company was at the time of the filing of the Registration Statement eligible
to use Form F-3. The Company is eligible to use Form F-3 under the Securities Act and it meets the transaction requirements with
respect to the aggregate market value of securities being sold pursuant to this offering and during the twelve (12) calendar months,
immediately prior to this offering, all as set forth in General Instruction I.B.5 of Form F-3.

 

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(g) Capitalization.
The capitalization of the Company is as set forth on Schedule 3.1(g). Other than as set forth on Schedule 3.1(g), the Company has
not issued any capital stock since its most recently filed periodic report under the Exchange Act, other than pursuant to the exercise
of employee stock options under the Company’s stock option plans, the issuance of Ordinary Shares, Ordinary Share Equivalents
or ADSs to employees pursuant to the Company’s employee stock purchase plans and pursuant to the conversion and/or exercise
of Ordinary Share Equivalents outstanding as of the date of the most recently filed periodic report under the Exchange Act. No
Person has any right of first refusal, preemptive right, right of participation, or any similar right to participate in the transactions
contemplated by the Transaction Documents. Other than as set forth on Schedule 3.1(g), except as a result of the purchase and sale
of the Securities, there are no outstanding options, warrants, scrip rights to subscribe to, calls or commitments of any character
whatsoever relating to, or securities, rights or obligations convertible into or exercisable or exchangeable for, or giving any
Person any right to subscribe for or acquire, any Ordinary Shares, ADSs or the capital stock of any Subsidiary, or contracts, commitments,
understandings or arrangements by which the Company or any Subsidiary is or may become bound to issue ADSs or additional Ordinary
Shares or Ordinary Share Equivalents or capital stock of any Subsidiary. Other than as set forth on Schedule 3.1(g), the issuance
and sale of the Securities will not obligate the Company or any Subsidiary to issue ADSs or Ordinary Shares or other securities
to any Person (other than the Purchasers) and will not result in a right of any holder of Company securities to adjust the exercise,
conversion, exchange or reset price under any of such securities. There are no outstanding securities or instruments of the Company
or any Subsidiary that contain any redemption or similar provisions, and there are no contracts, commitments, understandings or
arrangements by which the Company or any Subsidiary is or may become bound to redeem a security of the Company or such Subsidiary.
The Company does not have any stock appreciation rights or “phantom stock” plans or agreements or any similar plan
or agreement. All of the outstanding shares of capital stock of the Company are duly authorized, validly issued, fully paid and
nonassessable, have been issued in compliance with all federal and state securities laws, and none of such outstanding shares was
issued in violation of any preemptive rights or similar rights to subscribe for or purchase securities. No further approval or
authorization of any stockholder, the Board of Directors or others is required for the issuance and sale of the Securities. There
are no stockholders agreements, voting agreements or other similar agreements with respect to the Company’s capital stock
to which the Company is a party or, to the knowledge of the Company, between or among any of the Company’s stockholders.

 

(h) SEC
Reports; Financial Statements. The Company has filed all reports, schedules, forms, statements and other documents required
or permitted, including current reports on Form 6-K, to be filed by the Company under the Securities Act and the Exchange Act,
including pursuant to Section 13(a) or 15(d) thereof, for the two years preceding the date hereof (or such shorter period as the
Company was required by law or regulation to file such material) (the foregoing materials, including the exhibits thereto and documents
incorporated by reference therein, together with the Prospectus and the Prospectus Supplement, being collectively referred to herein
as the “SEC Reports”) on a timely basis or has received a valid extension of such time of filing and has filed
any such SEC Reports prior to the expiration of any such extension. As of their respective dates, the SEC Reports complied in all
material respects with the requirements of the Securities Act and the Exchange Act, as applicable, and none of the SEC Reports,
when filed, contained any untrue statement of a material fact or omitted to state a material fact required to be stated therein
or necessary in order to make the statements therein, in the light of the circumstances under which they were made, not misleading.
The Company has never been an issuer subject to Rule 144(i) under the Securities Act. The financial statements of the Company included
in the SEC Reports comply in all material respects with applicable accounting requirements and the rules and regulations of the
Commission with respect thereto as in effect at the time of filing. Such financial statements have been prepared in accordance
with International Financial Reporting Standards applied on a consistent basis during the periods involved (“IFRS”),
except as may be otherwise specified in such financial statements or the notes thereto and except that unaudited financial statements
may not contain all footnotes required by IFRS, and fairly present in all material respects the financial position of the Company
and its consolidated Subsidiaries as of and for the dates thereof and the results of operations and cash flows for the periods
then ended, subject, in the case of unaudited statements, to normal, immaterial, year-end audit adjustments.

 

    -11-

     

    

 

(i) Material
Changes; Undisclosed Events, Liabilities or Developments. Since the date of the latest audited financial statements included
within the SEC Reports, except as specifically disclosed in a subsequent SEC Report filed prior to the date hereof, (i) there has
been no event, occurrence or development that has had or that could reasonably be expected to result in a Material Adverse Effect,
(ii) the Company has not incurred any liabilities (contingent or otherwise) other than (A) trade payables and accrued expenses
incurred in the ordinary course of business consistent with past practice and (B) liabilities not required to be reflected in the
Company’s financial statements pursuant to IFRS or disclosed in the SEC Reports, (iii) the Company has not altered its method
of accounting, (iv) the Company has not declared or made any dividend or distribution of cash or other property to its stockholders
or purchased, redeemed or made any agreements to purchase or redeem any shares of its capital stock and (v) the Company has not
issued any equity securities to any officer, director or Affiliate, except pursuant to existing Company stock option plans. The
Company does not have pending before the Commission any request for confidential treatment of information. Except for the issuance
of the Securities contemplated by this Agreement, no event, liability, fact, circumstance, occurrence or development has occurred
or exists or is reasonably expected to occur or exist with respect to the Company or its Subsidiaries or their respective businesses,
prospects, properties, operations, assets or financial condition that would be required to be disclosed by the Company under applicable
securities laws at the time this representation is made or deemed made that has not been publicly disclosed at least one (1) Trading
Day prior to the date that this representation is made.

 

(j) Litigation.
Other than as disclosed on Schedule 3.1(j) , there is no action, suit, inquiry, notice of violation, proceeding or investigation
pending or, to the knowledge of the Company, threatened against or affecting the Company, any Subsidiary or any of their respective
properties before or by any court, arbitrator, governmental or administrative agency or regulatory authority (federal, state, county,
local or foreign) (collectively, an “Action”) which (i) adversely affects or challenges the legality, validity
or enforceability of any of the Transaction Documents or the Securities or (ii) could, if there were an unfavorable decision, have
or reasonably be expected to result in a Material Adverse Effect. Neither the Company nor any Subsidiary, nor, to the Company’s
knowledge, any director or officer thereof, is or has been the subject of any Action involving a claim of violation of or liability
under federal or state securities laws or a claim of breach of fiduciary duty which would, if there were an unfavorable decision,
have or reasonably be expected to result in a Material Adverse Effect. There has not been, and to the knowledge of the Company,
there is not pending or contemplated, any investigation by the Commission involving the Company or any current or former director
or officer of the Company. The Commission has not issued any stop order or other order suspending the effectiveness of any registration
statement filed by the Company or any Subsidiary under the Exchange Act or the Securities Act.

 

    -12-

     

    

 

(k) Labor
Relations. No material labor dispute exists or, to the knowledge of the Company, is imminent with respect to any of the employees
of the Company, which could reasonably be expected to result in a Material Adverse Effect. None of the Company’s or its Subsidiaries’
employees is a member of a union that relates to such employee’s relationship with the Company or such Subsidiary, and neither
the Company nor any of its Subsidiaries is a party to a collective bargaining agreement, and the Company and its Subsidiaries believe
that their relationships with their employees are good. To the knowledge of the Company, no executive officer of the Company or
any Subsidiary, is, or is now expected to be, in violation of any material term of any employment contract, confidentiality, disclosure
or proprietary information agreement or non-competition agreement, or any other contract or agreement or any restrictive covenant
in favor of any third party, and the continued employment of each such executive officer does not subject the Company or any of
its Subsidiaries to any liability with respect to any of the foregoing matters. The Company and its Subsidiaries are in compliance
with all U.S. federal, state, local and foreign laws and regulations relating to employment and employment practices, terms and
conditions of employment and wages and hours, except where the failure to be in compliance could not, individually or in the aggregate,
reasonably be expected to have a Material Adverse Effect.

 

(l) Compliance.
Neither the Company nor any Subsidiary: (i) is in default under or in violation of (and no event has occurred that has not been
waived that, with notice or lapse of time or both, would result in a default by the Company or any Subsidiary under), nor has the
Company or any Subsidiary received notice of a claim that it is in default under or that it is in violation of, any indenture,
loan or credit agreement or any other agreement or instrument to which it is a party or by which it or any of its properties is
bound (whether or not such default or violation has been waived), (ii) is in violation of any judgment, decree or order of any
court, arbitrator or other governmental authority or (iii) is or has been in violation of any statute, rule, ordinance or regulation
of any governmental authority, including without limitation all foreign, federal, state and local laws relating to taxes, environmental
protection, occupational health and safety, product quality and safety and employment and labor matters, except in each case as
could not have or reasonably be expected to result in a Material Adverse Effect.

 

(m) Environmental
Laws. The Company and its Subsidiaries (i) are in compliance with all federal, state, local and foreign laws relating to pollution
or protection of human health or the environment (including ambient air, surface water, groundwater, land surface or subsurface
strata), including laws relating to emissions, discharges, releases or threatened releases of chemicals, pollutants, contaminants,
or toxic or hazardous substances or wastes (collectively, “Hazardous Materials”) into the environment, or otherwise
relating to the manufacture, processing, distribution, use, treatment, storage, disposal, transport or handling of Hazardous Materials,
as well as all authorizations, codes, decrees, demands, or demand letters, injunctions, judgments, licenses, notices or notice
letters, orders, permits, plans or regulations, issued, entered, promulgated or approved thereunder (“Environmental Laws”);
(ii) have received all permits licenses or other approvals required of them under applicable Environmental Laws to conduct their
respective businesses; and (iii) are in compliance with all terms and conditions of any such permit, license or approval where
in each clause (i), (ii) and (iii), the failure to so comply could be reasonably expected to have, individually or in the aggregate,
a Material Adverse Effect.

 

(n) Regulatory
Permits. The Company and the Subsidiaries possess all certificates, authorizations and permits issued by the appropriate federal,
state, local or foreign regulatory authorities necessary to conduct their respective businesses as described in the SEC Reports,
except where the failure to possess such permits could not reasonably be expected to result in a Material Adverse Effect (“Material
Permits”), and neither the Company nor any Subsidiary has received any notice of proceedings relating to the revocation
or modification of any Material Permit.

 

    -13-

     

    

 

(o) Title
to Assets. The Company and the Subsidiaries have good and marketable title in fee simple to or have valid and marketable rights
to lease or otherwise use all real property that is described on the SEC Reports and good and marketable title in or have valid
and marketable rights to lease or otherwise use all personal property owned by them that is material to the business of the Company
and the Subsidiaries, in each case free and clear of all Liens, except for (i) Liens as do not materially affect the value of such
property and do not materially interfere with the use made and proposed to be made of such property by the Company and the Subsidiaries
and (ii) Liens for the payment of federal, state or other taxes, for which appropriate reserves have been made therefor in accordance
with IFRS and, the payment of which is neither delinquent nor subject to penalties. Any real property and facilities held under
lease by the Company and the Subsidiaries are held by them under valid, subsisting and enforceable leases with which the Company
and the Subsidiaries are in compliance in all material respects.

 

(p) Intellectual
Property. The Company and the Subsidiaries have, or have rights to use, all patents, patent applications, trademarks, trademark
applications, service marks, trade names, trade secrets, inventions, copyrights, licenses and other intellectual property rights
and similar rights necessary or required for use in connection with their respective businesses as described in the SEC Reports
and which the failure to so have could not reasonably be expected to have a Material Adverse Effect (collectively, the “Intellectual
Property Rights”). None of, and neither the Company nor any Subsidiary has received a notice (written or otherwise) that
any of the Intellectual Property Rights has expired, terminated or been abandoned, or is expected to expire or terminate or be
abandoned, within two (2) years from the date of this Agreement. Neither the Company nor any Subsidiary has received, since the
date of the latest audited financial statements included within the SEC Reports, a written notice of a claim or otherwise has any
knowledge that the Intellectual Property Rights violate or infringe upon the rights of any Person, except as could not have or
reasonably be expected to not have a Material Adverse Effect. To the knowledge of the Company, all such Intellectual Property Rights
are enforceable and there is no existing infringement by another Person of any of the Intellectual Property Rights. The Company
and its Subsidiaries have taken reasonable security measures to protect the secrecy, confidentiality and value of all of their
intellectual properties, except where failure to do so could not, individually or in the aggregate, reasonably be expected to have
a Material Adverse Effect.

 

(q) Insurance.
The Company and the Subsidiaries are insured by insurers of recognized financial responsibility against such losses and risks and
in such amounts as are prudent and customary in the businesses in which the Company and the Subsidiaries are engaged, including,
but not limited to, directors and officers insurance coverage as described Schedule 3.1(q). Neither the Company nor any Subsidiary
has any reason to believe that it will not be able to renew its existing insurance coverage as and when such coverage expires or
to obtain similar coverage from similar insurers as may be necessary to continue its business without a significant increase in
cost.

 

(r) Transactions
With Affiliates and Employees. Except as set forth in the SEC Reports, none of the officers or directors of the Company or
any Subsidiary and, to the knowledge of the Company, none of the employees of the Company or any Subsidiary is presently a party
to any transaction with the Company or any Subsidiary (other than for services as employees, officers and directors), including
any contract, agreement or other arrangement providing for the furnishing of services to or by, providing for rental of real or
personal property to or from, providing for the borrowing of money from or lending of money to or otherwise requiring payments
to or from any officer, director or such employee or, to the knowledge of the Company, any entity in which any officer, director,
or any such employee has a substantial interest or is an officer, director, trustee, stockholder, member or partner, in each case
in excess of $120,000 other than for (i) payment of salary or consulting fees for services rendered, (ii) reimbursement for expenses
incurred on behalf of the Company and (iii) other employee benefits, including stock option agreements under any stock option plan
of the Company.

 

    -14-

     

    

 

(s) Sarbanes-Oxley;
Internal Accounting Controls. The Company and the Subsidiaries are in material compliance with any and all applicable requirements
of the Sarbanes-Oxley Act of 2002 that are effective as of the date hereof, and any and all applicable rules and regulations promulgated
by the Commission thereunder that are effective as of the date hereof and as of the Closing Date. Except as set forth in the SEC
Reports, the Company and the Subsidiaries maintain a system of internal accounting controls sufficient to provide reasonable assurance
that: (i) transactions are executed in accordance with management’s general or specific authorizations, (ii) transactions
are recorded as necessary to permit preparation of financial statements in conformity with IFRS and to maintain asset accountability,
(iii) access to assets is permitted only in accordance with management’s general or specific authorization, and (iv) the
recorded accountability for assets is compared with the existing assets at reasonable intervals and appropriate action is taken
with respect to any differences. The Company and the Subsidiaries have established disclosure controls and procedures (as defined
in Exchange Act Rules 13a-15(e) and 15d-15(e)) for the Company and the Subsidiaries and designed such disclosure controls and procedures
to ensure that information required to be disclosed by the Company in the reports it files or submits under the Exchange Act is
recorded, processed, summarized and reported, within the time periods specified in the Commission’s rules and forms. The
Company’s certifying officers have evaluated the effectiveness of the disclosure controls and procedures of the Company and
the Subsidiaries as of the end of the period covered by the most recently filed Annual Report on Form 20-F under the Exchange Act
(such date, the “Evaluation Date”). The Company presented in its most recently filed Annual Report on Form 20-F
under the Exchange Act the conclusions of the certifying officers about the effectiveness of the disclosure controls and procedures
based on their evaluations as of the Evaluation Date. Since the Evaluation Date, there have been no changes in the internal control
over financial reporting (as such term is defined in the Exchange Act) of the Company and its Subsidiaries that have materially
affected, or is reasonably likely to materially affect, the internal control over financial reporting of the Company and its Subsidiaries.

 

(t) Certain
Fees. Except as set forth on Schedule 3.1(t) or in the Prospectus Supplement, no brokerage or finder’s fees or commissions
are or will be payable by the Company or any Subsidiary to any broker, financial advisor or consultant, finder, placement agent,
investment banker, bank or other Person with respect to the transactions contemplated by the Transaction Documents. The Purchasers
shall have no obligation with respect to any fees or with respect to any claims made by or on behalf of other Persons for fees
of a type contemplated in this Section that may be due in connection with the transactions contemplated by the Transaction Documents.

 

(u) Investment
Company. The Company is not, and is not an Affiliate of, and immediately after receipt of payment for the Securities, will
not be or be an Affiliate of, an “investment company” within the meaning of the Investment Company Act of 1940, as
amended. The Company shall conduct its business in a manner so that it will not become an “investment company” subject
to registration under the Investment Company Act of 1940, as amended.

 

    -15-

     

    

 

(v) Registration
Rights. Except as disclosed in the SEC Reports, no Person has any right to cause the Company or any Subsidiary to effect the
registration under the Securities Act of any securities of the Company or any Subsidiary.

 

(w) Listing
and Maintenance Requirements. The ADSs are registered pursuant to Section 12(b) or 12(g) of the Exchange Act, and the Company
has taken no action designed to, or which to its knowledge is likely to have the effect of, terminating the registration of the
ADSs under the Exchange Act nor has the Company received any notification that the Commission is contemplating terminating such
registration. The Company has not, in the 12 months preceding the date hereof, received notice from any Trading Market on which
the ADSs are or have been listed or quoted to the effect that the Company is not in compliance with the listing or maintenance
requirements of such Trading Market. The Company is, and has no reason to believe that it will not in the foreseeable future continue
to be, in material compliance with all such listing and maintenance requirements. The ADSs are currently eligible for electronic
transfer through the Depository Trust Company or another established clearing corporation and the Company is current in payment
of the fees to the Depository Trust Company (or such other established clearing corporation) in connection with such electronic
transfer.

 

(x) Application
of Takeover Protections. The Company and the Board of Directors have taken all necessary action, if any, in order to render
inapplicable any control share acquisition, business combination, poison pill (including any distribution under a rights agreement)
or other similar anti-takeover provision under the Company’s articles of association (or similar charter documents) or the
laws of its state of incorporation that is or could become applicable to the Purchasers as a result of the Purchasers and the Company
fulfilling their obligations or exercising their rights under the Transaction Documents, including without limitation as a result
of the Company’s issuance of the Securities and the Purchasers’ ownership of the Securities.

 

(y) Disclosure.
Except with respect to the material terms and conditions of the transactions contemplated by the Transaction Documents, the Company
confirms that neither it nor any other Person acting on its behalf has provided any of the Purchasers or their agents or counsel
with any information that it believes constitutes or might constitute material, non-public information which is not otherwise disclosed
in the Prospectus Supplement. The Company understands and confirms that the Purchasers will rely on the foregoing representation
in effecting transactions in securities of the Company. All of the disclosure furnished by or on behalf of the Company to the Purchasers
regarding the Company and its Subsidiaries, their respective businesses and the transactions contemplated hereby, including the
Disclosure Schedules to this Agreement, is true and correct and does not contain any untrue statement of a material fact or omit
to state any material fact necessary in order to make the statements made therein, in the light of the circumstances under which
they were made, not misleading. The press releases disseminated by the Company during the twelve months preceding the date of this
Agreement taken as a whole do not contain any untrue statement of a material fact or omit to state a material fact required to
be stated therein or necessary in order to make the statements therein, in the light of the circumstances under which they were
made and when made, not misleading. The Company acknowledges and agrees that no Purchaser makes or has made any representations
or warranties with respect to the transactions contemplated hereby other than those specifically set forth in Section 3.2 hereof.

 

    -16-

     

    

 

(z) No
Integrated Offering. Assuming the accuracy of the Purchasers’ representations and warranties set forth in Section 3.2,
neither the Company, nor any of its Affiliates, nor any Person acting on its or their behalf has, directly or indirectly, made
any offers or sales of any security or solicited any offers to buy any security, under circumstances that would cause this offering
of the Securities to be integrated with prior offerings by the Company for purposes of (i) the Securities Act which would require
the registration of the Warrants or Warrant Shares under the Securities Act, or (ii) any applicable shareholder approval provisions
of any Trading Market on which any of the securities of the Company are listed or designated.

 

(aa) Solvency.
Based on the consolidated financial condition of the Company as of the Closing Date, after giving effect to the receipt by the
Company of the proceeds from the sale of the Securities hereunder, (i) the fair saleable value of the Company’s assets exceeds
the amount that will be required to be paid on or in respect of the Company’s existing debts and other liabilities (including
known contingent liabilities) as they mature, (ii) the Company’s assets do not constitute unreasonably small capital to carry
on its business as now conducted and as proposed to be conducted including its capital needs taking into account the particular
capital requirements of the business conducted by the Company, consolidated and projected capital requirements and capital availability
thereof, and (iii) the current cash flow of the Company, together with the proceeds the Company would receive, were it to liquidate
all of its assets, after taking into account all anticipated uses of the cash, would be sufficient to pay all amounts on or in
respect of its liabilities when such amounts are required to be paid. The Company does not intend to incur debts beyond its ability
to pay such debts as they mature (taking into account the timing and amounts of cash to be payable on or in respect of its debt).
The Company has no knowledge of any facts or circumstances which lead it to believe that it will file for reorganization or liquidation
under the bankruptcy or reorganization laws of any jurisdiction within one year from the Closing Date. Schedule 3.1(aa) sets forth
as of the date hereof all outstanding secured and unsecured Indebtedness of the Company or any Subsidiary, or for which the Company
or any Subsidiary has commitments. For the purposes of this Agreement, “Indebtedness” means (x) any liabilities
for borrowed money or amounts owed in excess of $100,000 (other than trade accounts payable incurred in the ordinary course of
business), (y) all guaranties, endorsements and other contingent obligations in respect of indebtedness of others, whether or not
the same are or should be reflected in the Company’s consolidated balance sheet (or the notes thereto), except guaranties
by endorsement of negotiable instruments for deposit or collection or similar transactions in the ordinary course of business;
and (z) the present value of any lease payments in excess of $100,000 due under leases required to be capitalized in accordance
with IFRS. Neither the Company nor any Subsidiary is in default with respect to any Indebtedness.

 

(bb) Tax
Status. Except for matters that would not, individually or in the aggregate, have or reasonably be expected to result in a
Material Adverse Effect, the Company and its Subsidiaries each (i) has made or filed all United States federal, state and local
income and all foreign income and franchise tax returns, reports and declarations required by any jurisdiction to which it is subject,
(ii) has paid all taxes and other governmental assessments and charges that are material in amount, shown or determined to be due
on such returns, reports and declarations and (iii) has set aside on its books provision reasonably adequate for the payment of
all material taxes for periods subsequent to the periods to which such returns, reports or declarations apply. There are no unpaid
taxes in any material amount claimed to be due by the taxing authority of any jurisdiction, and the officers of the Company or
of any Subsidiary know of no basis for any such claim.

 

(cc) Foreign
Corrupt Practices. Neither the Company nor any Subsidiary, nor to the knowledge of the Company or any Subsidiary, any agent
or other person acting on behalf of the Company or any Subsidiary, has (i) directly or indirectly, used any funds for unlawful
contributions, gifts, entertainment or other unlawful expenses related to foreign or domestic political activity, (ii) made any
unlawful payment to foreign or domestic government officials or employees or to any foreign or domestic political parties or campaigns
from corporate funds, (iii) failed to disclose fully any contribution made by the Company or any Subsidiary (or made by any person
acting on its behalf of which the Company is aware) which is in violation of law, or (iv) violated in any material respect any
provision of FCPA.

 

    -17-

     

    

 

(dd) Accountants.
The Company’s accounting firm is set forth in the SEC Reports. To the knowledge and belief of the Company, such accounting
firm (i) is a registered public accounting firm as required by the Exchange Act and (ii) shall express its opinion with respect
to the financial statements to be included in the Company’s Annual Report for the fiscal year ended December 31, 2018.

 

(ee) Acknowledgment
Regarding Purchasers’ Purchase of Securities. The Company acknowledges and agrees that each of the Purchasers is acting
solely in the capacity of an arm’s length purchaser with respect to the Transaction Documents and the transactions contemplated
thereby. The Company further acknowledges that no Purchaser is acting as a financial advisor or fiduciary of the Company (or in
any similar capacity) with respect to the Transaction Documents and the transactions contemplated thereby and any advice given
by any Purchaser or any of their respective representatives or agents in connection with the Transaction Documents and the transactions
contemplated thereby is merely incidental to the Purchasers’ purchase of the Securities. The Company further represents to
each Purchaser that the Company’s decision to enter into this Agreement and the other Transaction Documents has been based
solely on the independent evaluation of the transactions contemplated hereby by the Company and its representatives.

 

(ff) Acknowledgment
Regarding Purchaser’s Trading Activity. Anything in this Agreement or elsewhere herein to the contrary notwithstanding
(except for Sections 3.2(f) and 4.13 hereof), it is understood and acknowledged by the Company that: (i) none of the Purchasers
has been asked by the Company to agree, nor has any Purchaser agreed, to desist from purchasing or selling, long and/or short,
securities of the Company, or “derivative” securities based on securities issued by the Company or to hold the Securities
for any specified term; (ii) past or future open market or other transactions by any Purchaser, specifically including, without
limitation, Short Sales or “derivative” transactions, before or after the closing of this or future private placement
transactions, may negatively impact the market price of the Company’s publicly-traded securities; (iii) any Purchaser, and
counter-parties in “derivative” transactions to which any such Purchaser is a party, directly or indirectly, presently
may have a “short” position in the ADSs, and (iv) each Purchaser shall not be deemed to have any affiliation with or
control over any arm’s length counter-party in any “derivative” transaction. The Company further understands
and acknowledges that (y) one or more Purchasers may engage in hedging activities at various times during the period that the Securities
are outstanding, including, without limitation, during the periods that the value of the Warrant Shares deliverable with respect
to Securities are being determined, and (z) such hedging activities (if any) could reduce the value of the existing stockholders'
equity interests in the Company at and after the time that the hedging activities are being conducted. The Company acknowledges
that such aforementioned hedging activities do not constitute a breach of any of the Transaction Documents.

 

    -18-

     

    

 

(gg) Regulation
M Compliance. The Company has not, and to its knowledge no one acting on its behalf has, (i) taken, directly or indirectly,
any action designed to cause or to result in the stabilization or manipulation of the price of any security of the Company to facilitate
the sale or resale of any of the Securities, (ii) sold, bid for, purchased, or, paid any compensation for soliciting purchases
of, any of the Securities, or (iii) paid or agreed to pay to any Person any compensation for soliciting another to purchase any
other securities of the Company, other than, in the case of clauses (ii) and (iii), as set forth in the Prospectus Supplement.

 

(hh) FDA.
As to each product subject to the jurisdiction of the U.S. Food and Drug Administration (“FDA”) under the Federal
Food, Drug and Cosmetic Act, as amended, and the regulations thereunder (“FDCA”) that is manufactured, packaged,
labeled, tested, distributed, sold, and/or marketed by the Company or any of its Subsidiaries (each such product, a “Pharmaceutical
Product”), such Pharmaceutical Product is being manufactured, packaged, labeled, tested, distributed, sold and/or marketed
by the Company in compliance with all applicable requirements under FDCA and similar laws, rules and regulations relating to registration,
investigational use, premarket clearance, licensure, or application approval, good manufacturing practices, good laboratory practices,
good clinical practices, product listing, quotas, labeling, advertising, record keeping and filing of reports, except where the
failure to be in compliance would not have a Material Adverse Effect. There is no pending, completed or, to the Company's knowledge,
threatened, action (including any lawsuit, arbitration, or legal or administrative or regulatory proceeding, charge, complaint,
or investigation) against the Company or any of its Subsidiaries, and none of the Company or any of its Subsidiaries has received
any notice, warning letter or other communication from the FDA or any other governmental entity, which (i) contests the premarket
clearance, licensure, registration, or approval of, the uses of, the distribution of, the manufacturing or packaging of, the testing
of, the sale of, or the labeling and promotion of any Pharmaceutical Product, (ii) withdraws its approval of, requests the recall,
suspension, or seizure of, or withdraws or orders the withdrawal of advertising or sales promotional materials relating to, any
Pharmaceutical Product, (iii) imposes a clinical hold on any clinical investigation by the Company or any of its Subsidiaries,
(iv) enjoins production at any facility of the Company or any of its Subsidiaries, (v) enters or proposes to enter into a consent
decree of permanent injunction with the Company or any of its Subsidiaries, or (vi) otherwise alleges any violation of any laws,
rules or regulations by the Company or any of its Subsidiaries, and which, either individually or in the aggregate, would have
a Material Adverse Effect. The properties, business and operations of the Company have been and are being conducted in all material
respects in accordance with all applicable laws, rules and regulations of the FDA. The Company has not been informed by the FDA
that the FDA will prohibit the marketing, sale, license or use in the United States of any product proposed to be developed, produced
or marketed by the Company. The FDA has not expressed any concern as to approving or clearing for marketing any product being developed
or proposed to be developed by the Company which would have a Material Adverse Effect.

 

(ii) Office
of Foreign Assets Control. Neither the Company nor any Subsidiary nor, to the Company's knowledge, any director, officer, agent,
employee or affiliate of the Company or any Subsidiary is currently subject to any U.S. sanctions administered by the Office of
Foreign Assets Control of the U.S. Treasury Department (“OFAC”).

 

(jj) U.S.
Real Property Holding Corporation. The Company is not and has never been a U.S. real property holding corporation within the
meaning of Section 897 of the Internal Revenue Code of 1986, as amended, and the Company shall so certify upon Purchaser’s
reasonable request.

 

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(kk) Bank
Holding Company Act. Neither the Company nor any of its Subsidiaries or Affiliates is subject to the Bank Holding Company Act
of 1956, as amended (the “BHCA”) and to regulation by the Board of Governors of the Federal Reserve System (the
“Federal Reserve”). Neither the Company nor any of its Subsidiaries or Affiliates owns or controls, directly
or indirectly, five percent (5%) or more of the outstanding shares of any class of voting securities or twenty-five percent (25%)
or more of the total equity of a bank or any entity that is subject to the BHCA and to regulation by the Federal Reserve. Neither
the Company nor any of its Subsidiaries or Affiliates exercises a controlling influence over the management or policies of a bank
or any entity that is subject to the BHCA and to regulation by the Federal Reserve.

 

(ll) Money
Laundering. The operations of the Company and its Subsidiaries are and have been conducted at all times in compliance with
applicable financial record-keeping and reporting requirements of the Currency and Foreign Transactions Reporting Act of 1970,
as amended, applicable money laundering statutes and applicable rules and regulations thereunder (collectively, the “Money
Laundering Laws”), and no Action or Proceeding by or before any court or governmental agency, authority or body or any
arbitrator involving the Company or any Subsidiary with respect to the Money Laundering Laws is pending or, to the knowledge of
the Company or any Subsidiary, threatened.

 

(mm) Private
Placement. Assuming the accuracy of the Purchasers’ representations and warranties set forth in Section 3.2, no registration
under the Securities Act is required for the offer and sale of the Warrants or the Warrant Shares by the Company to the Purchasers
as contemplated hereby.

 

(nn) No
General Solicitation. Neither the Company nor any Person acting on behalf of the Company has offered or sold any of the Warrant
or Warrant Shares by any form of general solicitation or general advertising. The Company has offered the Warrants and Warrant
Shares for sale only to the Purchasers and certain other “accredited investors” within the meaning of Rule 501 under
the Securities Act.

 

(oo) No
Disqualification Events. With respect to the Warrant and Warrant Shares to be offered and sold hereunder in reliance on Rule
506 under the Securities Act, none of the Company, any of its predecessors, any affiliated issuer, any director, executive officer,
other officer of the Company participating in the offering hereunder, any beneficial owner of 20% or more of the Company’s
outstanding voting equity securities, calculated on the basis of voting power, nor any promoter (as that term is defined in Rule
405 under the Securities Act) connected with the Company in any capacity at the time of sale (each, an “Issuer Covered
Person”) is subject to any of the “Bad Actor” disqualifications described in Rule 506(d)(1)(i) to (viii)
under the Securities Act (a “Disqualification Event”), except for a Disqualification Event covered by Rule 506(d)(2)
or (d)(3). The Company has exercised reasonable care to determine whether any Issuer Covered Person is subject to a Disqualification
Event. The Company has complied, to the extent applicable, with its disclosure obligations under Rule 506(e), and has furnished
to the Purchasers a copy of any disclosures provided thereunder.

 

(pp) Other
Covered Persons. The Company is not aware of any person that has been or will be paid (directly or indirectly) remuneration
for solicitation of purchasers in connection with the sale of any Securities, other than as set forth in the Prospectus Supplement.

 

(qq) Notice
of Disqualification Events. The Company will notify the Purchasers in writing, prior to the Closing Date of (i) any Disqualification
Event relating to any Issuer Covered Person and (ii) any event that would, with the passage of time, reasonably be expected to
become a Disqualification Event relating to any Issuer Covered Person, in each case of which it is aware.

 

    -20-

     

    

 

3.2 Representations
and Warranties of the Purchasers. Each Purchaser, for itself and for no other Purchaser, hereby represents and warrants as
of the date hereof and as of the Closing Date to the Company as follows (unless as of a specific date therein, in which case they
shall be accurate as of such date):

 

(a) Organization;
Authority. Such Purchaser is either an individual or an entity duly incorporated or formed, validly existing and in good standing
under the laws of the jurisdiction of its incorporation or formation with full right, corporate, partnership, limited liability
company or similar power and authority to enter into and to consummate the transactions contemplated by the Transaction Documents
and otherwise to carry out its obligations hereunder and thereunder. The execution and delivery of the Transaction Documents and
performance by such Purchaser of the transactions contemplated by the Transaction Documents have been duly authorized by all necessary
corporate, partnership, limited liability company or similar action, as applicable, on the part of such Purchaser. Each Transaction
Document to which it is a party has been duly executed by such Purchaser, and when delivered by such Purchaser in accordance with
the terms hereof, will constitute the valid and legally binding obligation of such Purchaser, enforceable against it in accordance
with its terms, except: (i) as limited by general equitable principles and applicable bankruptcy, insolvency, reorganization, moratorium
and other laws of general application affecting enforcement of creditors’ rights generally, (ii) as limited by laws relating
to the availability of specific performance, injunctive relief or other equitable remedies and (iii) insofar as indemnification
and contribution provisions may be limited by applicable law.

 

(b) Understandings
or Arrangements. Such Purchaser is acquiring the Securities as principal for its own account and has no direct or indirect
arrangement or understandings with any other persons to distribute or regarding the distribution of such Securities (this representation
and warranty not limiting such Purchaser’s right to sell the Securities pursuant to the Registration Statement or otherwise
in compliance with applicable federal and state securities laws). Such Purchaser is acquiring the Securities hereunder in the ordinary
course of its business. Such Purchaser understands that the Warrants and the Warrant Shares are “restricted securities”
and have not been registered under the Securities Act or any applicable state securities law and is acquiring such Securities as
principal for his, her or its own account and not with a view to or for distributing or reselling such Securities or any part thereof
in violation of the Securities Act or any applicable state securities law, has no present intention of distributing any of such
Securities in violation of the Securities Act or any applicable state securities law and has no direct or indirect arrangement
or understandings with any other persons to distribute or regarding the distribution of such Securities in violation of the Securities
Act or any applicable state or Israeli securities law (this representation and warranty not limiting such Purchaser’s right
to sell such Securities pursuant to a registration statement or otherwise in compliance with applicable federal and state securities
laws).

 

(c) Purchaser
Status. At the time such Purchaser was offered the Securities, it was, and as of the date hereof it is, and on each date on
which it exercises any Warrants, it will be either:

 

(i) if the Purchaser is located
in the U.S., an “accredited investor” as defined in Rule 501(a)(1), (a)(2), (a)(3), (a)(5), (a)(6), (a)(7) or (a)(8)
under the Securities Act,

 

(ii) if the Purchaser is located
in the State of Israel, (A) an Israeli investor which falls within the scope of one of the criteria of Qualified Investor pursuant
to the First Addendum of the Securities Law and (B) located outside the United States and not a "U.S. Person" as defined
in Rule 902 under the Securities Act, and

 

    -21-

     

    

 

(iii) if the Purchaser is located
in another non-U.S. jurisdiction, (A) a non-U.S. and non-Israeli investor qualifying as a “qualified investor” or comparable
term as defined in the applicable jurisdiction under circumstances that will result in compliance with the applicable rules and
regulations of that jurisdiction and (B) located outside the United States and not a "U.S. Person" as defined in Rule
902 under the Securities Act.

 

At the time such Purchaser
was offered the Securities, it was not, and as of the date hereof it is not, and on each date on which it exercises any Warrants,
it will not: (i) be an Enemy of Israel (as such term is defined under the Israeli Trading with the Enemy Ordinance of 1939) nor
acting on behalf of or for the benefit of such, (ii) cause any transactional tax in Israel that is or may become payable by the
Depository or its custodian, due to the issuance and depositing or the sale of the Securities, (iii) be entitled to hold 25% or
more of the voting power in the Company, unless by means prescribed under the Israeli Companies Law pertaining to tender offering
rules and restriction, or (iv) be an officer of Company nor a holder of 5% or more of the Company’s issued and outstanding
share capital.

 

(d) Experience
of Such Purchaser. Such Purchaser, either alone or together with its representatives, has such knowledge, sophistication and
experience in business and financial matters so as to be capable of evaluating the merits and risks of the prospective investment
in the Securities, and has so evaluated the merits and risks of such investment. Such Purchaser is able to bear the economic risk
of an investment in the Securities and, at the present time, is able to afford a complete loss of such investment.

 

(e) Access
to Information. Such Purchaser acknowledges that it has had the opportunity to review the Transaction Documents (including
all exhibits and schedules thereto) and the SEC Reports and has been afforded, (i) the opportunity to ask such questions as it
has deemed necessary of, and to receive answers from, representatives of the Company concerning the terms and conditions of the
offering of the Securities and the merits and risks of investing in the Securities; (ii) access to information about the Company
and its financial condition, results of operations, business, properties, management and prospects sufficient to enable it to evaluate
its investment; and (iii) the opportunity to obtain such additional information that the Company possesses or can acquire without
unreasonable effort or expense that is necessary to make an informed investment decision with respect to the investment.

 

(f) Certain
Transactions and Confidentiality. Other than consummating the transactions contemplated hereunder, such Purchaser has not,
nor has any Person acting on behalf of or pursuant to any understanding with such Purchaser, directly or indirectly executed any
purchases or sales, including Short Sales, of the securities of the Company during the period commencing as of the time that such
Purchaser first received a term sheet (written or oral) from the Company or any other Person representing the Company setting forth
the material pricing terms of the transactions contemplated hereunder and ending immediately prior to the execution hereof. Notwithstanding
the foregoing, in the case of a Purchaser that is a multi-managed investment vehicle whereby separate portfolio managers manage
separate portions of such Purchaser’s assets and the portfolio managers have no direct knowledge of the investment decisions
made by the portfolio managers managing other portions of such Purchaser’s assets, the representation set forth above shall
only apply with respect to the portion of assets managed by the portfolio manager that made the investment decision to purchase
the Securities covered by this Agreement. Other than to other Persons party to this Agreement or to such Purchaser’s representatives,
including, without limitation, its officers, directors, partners, legal and other advisors, employees, agents and Affiliates, such
Purchaser has maintained the confidentiality of all disclosures made to it in connection with this transaction (including the existence
and terms of this transaction). Notwithstanding the foregoing, for the avoidance of doubt, nothing contained herein shall constitute
a representation or warranty, or preclude any actions, with respect to locating or borrowing shares in order to effect Short Sales
or similar transactions in the future.

 

    -22-

     

    

 

(g) Lock
Up. Such Purchaser is aware of the fact that the Ordinary Shares underlying the ADSs and the Warrants are not registered for
trading on the Tel Aviv Stock Exchange

 

(h) No Voting
Agreements. The Purchaser is not a party to any agreement or arrangement, whether written or oral, between the Purchaser and
any other Purchaser and any of the Company's shareholders as of the date hereof or a corporation in which the Company's shareholders
are an Interested Party (as defined in the Companies Law) as of the date hereof, regulating the management of the Company, the
shareholders' rights in the Company, the transfer of shares in the Company, including any voting agreements, shareholder agreements
or any other similar agreement even if its title is different or has any other relations or agreements with any of the Company's
shareholders, directors or officers.

 

(i) No Governmental
Review. Such Purchaser understands that no Israeli or United States federal or state agency or any other government or governmental
agency has passed on or made any recommendation or endorsement of the Securities or the fairness or suitability of the investment
in the Securities nor have such authorities passed upon or endorsed the merits of the offering of the Securities.

 

(j) Brokers.
Except as set forth on Schedule 3.2(j) or in the Prospectus Supplement, no agent, broker, investment banker, person or firm acting
in a similar capacity on behalf of or under the authority of the Purchaser is or will be entitled to any broker's or finder's fee
or any other commission or similar fee, directly or indirectly, for which the Company or any of its Affiliates after the Closing
could have any liabilities in connection with this Agreement, any of the transactions contemplated by this Agreement, or on account
of any action taken by the Purchaser in connection with the transactions contemplated by this Agreement.

 

(k) Independent
Advice. Each Purchaser understands that nothing in this Agreement or any other materials presented by or on behalf of the Company
to the Purchaser in connection with the purchase of the Securities constitutes legal, tax or investment advice.

 

(l) General
Solicitation. Such Purchaser is not purchasing the Securities as a result of any advertisement, article, notice or other communication
regarding the Securities published in any newspaper, magazine or similar media or broadcast over television or radio or presented
at any seminar or, to knowledge of such Purchaser, any other general solicitation or general advertisement.

 

The Company acknowledges and agrees that
the representations contained in this Section 3.2 shall not modify, amend or affect such Purchaser’s right to rely on the
Company’s representations and warranties contained in this Agreement or any representations and warranties contained in any
other Transaction Document or any other document or instrument executed and/or delivered in connection with this Agreement or the
consummation of the transactions contemplated hereby.

 

    -23-

     

    

 

ARTICLE IV.

OTHER AGREEMENTS OF THE PARTIES

 

4.1 Removal of Legends.

 

(a) The Warrants,
Warrant ADSs and Warrant Shares may only be disposed of in compliance with state and federal securities laws. In connection with
any transfer of Warrants, Warrant ADSs or Warrant Shares other than pursuant to an effective registration statement or Rule 144,
to the Company or to an Affiliate of a Purchaser or in connection with a pledge as contemplated in Section 4.1(b), the Company
may require the transferor thereof to provide to the Company an opinion of counsel selected by the transferor and reasonably acceptable
to the Company, the form and substance of which opinion shall be reasonably satisfactory to the Company, to the effect that such
transfer does not require registration of such transferred Warrant under the Securities Act.

 

(b) The Purchasers
agree to the imprinting, so long as is required by this Section 4.1, of a legend on any of the Warrants, Warrant ADSs or Warrant
Shares in the following form:

 

NEITHER THIS SECURITY NOR THE
SECURITIES INTO WHICH THIS SECURITY IS EXERCISABLE HAS BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES
COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES
ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES
ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE SECURITIES
ACT AND IN ACCORDANCE WITH APPLICABLE STATE SECURITIES LAWS. THIS SECURITY AND THE SECURITIES ISSUABLE UPON EXERCISE OF THIS SECURITY
MAY BE PLEDGED IN CONNECTION WITH A BONA FIDE MARGIN ACCOUNT OR OTHER LOAN SECURED BY SUCH SECURITIES.

 

(c) The Company
acknowledges and agrees that a Purchaser may from time to time pledge pursuant to a bona fide margin agreement with a registered
broker-dealer or grant a security interest in some or all of the Warrants, Warrant ADSs or Warrant Shares to a financial institution
that is an “accredited investor” as defined in Rule 501(a) under the Securities Act and, if required under the terms
of such arrangement, such Purchaser may transfer pledged or secured Warrants, Warrant ADSs or Warrant Shares to the pledgees or
secured parties. Such a pledge or transfer would not be subject to approval of the Company and no legal opinion of legal counsel
of the pledgee, secured party or pledgor shall be required in connection therewith. Further, no notice shall be required of such
pledge. At the appropriate Purchaser’s expense, the Company will execute and deliver such reasonable documentation as a pledgee
or secured party of Warrants and Warrant ADSs may reasonably request in connection with a pledge or transfer of the Warrants or
Warrant ADSs.

 

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(d) Certificates
evidencing the Warrant ADSs and Warrant Shares shall not contain any legend (including the legend set forth in Section 4.1(b) hereof):
(i) while a registration statement covering the resale of such security is effective under the Securities Act (and in the case
of affiliates, in connection with a specific contemplated resale), or (ii) following any sale of such Warrant Shares or Warrant
ADSs pursuant to Rule 144, or (iii) if such Warrant ADSs or Warrant Shares are eligible for sale without restriction or volume
limitations under Rule 144. The Company shall cause its counsel to issue a legal opinion to the Depositary promptly if required
by the Depositary to effect the removal of the legend hereunder subject to receipt of customary certifications from the Purchaser
in connection with such opinion. If all or any portion of a Warrant is exercised at a time when there is an effective registration
statement to cover the resale of the Warrant ADSs or Warrant Shares, or if such Warrant ADSs or Warrant Shares may be sold under
Rule 144 without restriction or volume limitations then such Warrant ADSs or Warrant Shares shall be issued free of all legends.
The Company agrees that following such time as such legend is no longer required under this Section 4.1(c), the Company will, no
later than the earlier of (i) two Trading Days and (ii) the number of Trading Days comprising the Standard Settlement Period (as
defined below) following the delivery by a Purchaser to the Company or the Depositary of a certificate representing Warrant ADSs
or Warrant Shares, as applicable, issued with a restrictive legend (such second Trading Day, the “Legend Removal Date”),
deliver or cause to be delivered to such Purchaser a certificate representing such securities that is free from all restrictive
and other legends. The Company may not make any notation on its records or give instructions to the Depositary that enlarge the
restrictions on transfer set forth in this Section 4. Certificates for Warrant ADSs subject to legend removal hereunder shall be
transmitted by the Depositary to the Purchaser by crediting the account of the Purchaser’s prime broker with the Depository
Trust Company System as directed by such Purchaser. As used herein, “Standard Settlement Period” means the standard
settlement period, expressed in a number of Trading Days, on the Company’s primary Trading Market with respect to the ADSs
as in effect on the date of delivery of a certificate representing Warrant ADSs issued with a restrictive legend.

 

(e) In addition
to such Purchaser’s other available remedies, the Company shall pay to a Purchaser, in cash, (i) as partial liquidated damages
and not as a penalty, for each $1,000 of Warrant Shares (based on the VWAP of the ADSs on the date such Securities are submitted
to the Transfer Agent) delivered for removal of the restrictive legend and subject to Section 4.1(c), $10 per Trading Day (increasing
to $20 per Trading Day five (5) Trading Days after such damages have begun to accrue) for each Trading Day after the Legend Removal
Date until such certificate is delivered without a legend and (ii) if the Company fails to (a) issue and deliver (or cause to be
delivered) to a Purchaser by the Legend Removal Date a certificate representing the Securities so delivered to the Company by such
Purchaser that is free from all restrictive and other legends and (b) if after the Legend Removal Date such Purchaser purchases
(in an open market transaction or otherwise) ADSs to deliver in satisfaction of a sale by such Purchaser of all or any portion
of the number of ADSs, or a sale of a number of ADSs equal to all or any portion of the number of ADSs, that such Purchaser anticipated
receiving from the Company without any restrictive legend, then an amount equal to the excess of such Purchaser’s total purchase
price (including brokerage commissions and other out-of-pocket expenses, if any) for the ADSs so purchased (including brokerage
commissions and other out-of-pocket expenses, if any) (the “Buy-In Price”) over the product of (A) such number of Warrant
ADSs that the Company was required to deliver to such Purchaser by the Legend Removal Date multiplied by (B) the lowest closing
sale price of the ADSs on any Trading Day during the period commencing on the date of the delivery by such Purchaser to the Company
of the applicable Warrant ADSs (as the case may be) and ending on the date of such delivery and payment under this Section 4.1(e).

 

(f) The Shares
issued and sold shall be issued free of legends.

 

    -25-

     

    

 

4.2 Furnishing of
Information.

 

(a) Until
no Purchaser owns Securities, the Company covenants to (i) use its best efforts to maintain the registration of the Securities
under the Exchange Act, and (ii) maintain the registration of the ADSs under Section 12(b) or 12(g) of the Exchange Act and to
timely file (or obtain extensions in respect thereof and file within the applicable grace period) all reports required to be filed
by the Company after the date hereof pursuant to the Exchange Act even if the Company is not then subject to the reporting requirements
of the Exchange Act. As long as any Purchaser owns Securities, if the Company is not required to file reports pursuant to the Exchange
Act, it will prepare and furnish to the Purchasers and make publicly available in accordance with Rule 144(c) such information
as is required for the Purchasers to sell the Securities, including without limitation, under Rule 144. The Company further covenants
that it will take such further action as any holder of Securities may reasonably request, to the extent required from time to time
to enable such Person to sell such Securities without registration under the Securities Act, including without limitation, within
the requirements of the exemption provided by Rule 144.

 

(b) At any
time during the period commencing from the six (6) month anniversary of the date hereof and ending at such time that all of the
Warrant ADSs (assuming cashless exercise) may be sold without the requirement for the Company to be in compliance with Rule 144(c)(1)
and otherwise without restriction or limitation pursuant to Rule 144, if the Company (i) shall fail for any reason to satisfy the
current public information requirement under Rule 144(c) or (ii) becomes an issuer described in Rule 144(i)(1)(i) in the future,
and the Company shall fail to satisfy any condition set forth in Rule 144(i)(2) (a “Public Information Failure”)
then, in addition to such Purchaser’s other available remedies, the Company shall pay to a Purchaser, in cash, as partial
liquidated damages and not as a penalty, by reason of any such delay in or reduction of its ability to sell the Warrant ADSs, an
amount in cash equal to two percent (2.0%) of the aggregate Exercise Price of such Purchaser’s Warrants commencing on the
day of a Public Information Failure (or, in the event that the Warrants are not “in the money” (i.e., the intrinsic
value of the Warrant is greater than zero) on the date of such Public Information Failure, on the earlier of (i) the 15th
day after such Public Information Failure or (ii) the first Trading Day after such Public Information Failure that the Warrants
are “in the money”) and on every thirtieth (30th) day (pro rated for periods totaling less than thirty days) thereafter
until the earlier of (a) the date such Public Information Failure is cured and (b) such time that such public information is no
longer required for the Purchasers to transfer the Warrant ADSs pursuant to Rule 144. The payments to which a Purchaser shall be
entitled pursuant to this Section 4.2(b) are referred to herein as “Public Information Failure Payments.” Public
Information Failure Payments shall be paid on the earlier of (i) the last day of the calendar month during which such Public Information
Failure Payments are incurred and (ii) the third (3rd) Business Day after the event or failure giving rise to the Public
Information Failure Payments is cured. In the event the Company fails to make Public Information Failure Payments in a timely manner,
such Public Information Failure Payments shall bear interest at the rate of 1.5% per month (prorated for partial months) until
paid in full. Nothing herein shall limit such Purchaser’s right to pursue actual damages for the Public Information Failure,
and such Purchaser shall have the right to pursue all remedies available to it at law or in equity including, without limitation,
a decree of specific performance and/or injunctive relief.

 

4.3 Integration.
The Company shall not sell, offer for sale or solicit offers to buy or otherwise negotiate in respect of any security (as defined
in Section 2 of the Securities Act) that would be integrated with the offer or sale of the Securities in a manner that would require
the registration under the Securities Act of the sale of the Warrants or Warrant Shares or that would be integrated with the offer
or sale of the Securities for purposes of the rules and regulations of any Trading Market such that it would require shareholder
approval prior to the closing of such other transaction unless shareholder approval is obtained before the closing of such subsequent
transaction.

 

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4.4 Securities Laws
Disclosure; Publicity. The Company shall (a) by the Disclosure Time, issue a press release disclosing the material terms of
the transactions contemplated hereby, and (b) file a Current Report on Form 6-K, including the Transaction Documents as exhibits
thereto, with the Commission within the time required by the Exchange Act. From and after the issuance of such press release, the
Company represents to the Purchasers that it shall have publicly disclosed all material, non-public information delivered to any
of the Purchasers by the Company or any of its Subsidiaries, or any of their respective officers, directors, employees or agents
in connection with the transactions contemplated by the Transaction Documents. In addition, effective upon the issuance of such
press release, the Company acknowledges and agrees that any and all confidentiality or similar obligations under any agreement,
whether written or oral, between the Company, any of its Subsidiaries or any of their respective officers, directors, agents, employees
or Affiliates on the one hand, and any of the Purchasers or any of their Affiliates on the other hand, shall terminate solely with
respect to the obligations of confidentiality in connection of the transactions contemplated hereby this Agreement. The Company
and each Purchaser shall consult with each other in issuing any other press releases with respect to the transactions contemplated
hereby, and neither the Company nor any Purchaser shall issue any such press release nor otherwise make any such public statement
without the prior consent of the Company, with respect to any press release of any Purchaser, or without the prior consent of each
Purchaser, with respect to any press release of the Company, which consent shall not unreasonably be withheld or delayed, except
if such disclosure is required by law, in which case the disclosing party shall promptly provide the other party with prior notice
of such public statement or communication. Notwithstanding the foregoing, the Company shall not be required to obtain the approval
of any Purchaser for any press releases not associated with the transactions contemplated hereby. Notwithstanding the foregoing,
the Company shall not publicly disclose the name of any Purchaser, or include the name of any Purchaser in any filing with the
Commission or any regulatory agency or Trading Market, without the prior written consent of such Purchaser, except (a) as required
by federal securities law in connection with the filing of final Transaction Documents with the Commission, (b) as required to
register the Warrant Shares in a resale registration statement, (c) to the extent such disclosure is required by law or Trading
Market regulations, in which case the Company shall provide the Purchasers with prior notice of such disclosure permitted under
this clause (c), and (d) the listing of Purchasers name in the Company’s register of securities holders, which registry is
open to the security holders of the Company and which may be filed publicly by the Company from time to time.

 

4.5 Shareholder
Rights Plan. No claim will be made or enforced by the Company or, with the consent of the Company, any other Person, that any
Purchaser is an “Acquiring Person” under any control share acquisition, business combination, poison pill (including
any distribution under a rights agreement) or similar anti-takeover plan or arrangement in effect or hereafter adopted by the Company,
or that any Purchaser could be deemed to trigger the provisions of any such plan or arrangement, by virtue of receiving Securities
under the Transaction Documents or under any other agreement between the Company and the Purchasers.

 

4.6 Non-Public Information.
Except with respect to the material terms and conditions of the transactions contemplated by the Transaction Documents, which shall
be disclosed pursuant to Section 4.4, the Company covenants and agrees that neither it, nor any other Person acting on its behalf
will provide any Purchaser or its agents or counsel with any information that constitutes, or the Company reasonably believes constitutes,
material non-public information, unless prior thereto such Purchaser shall have consented to the receipt of such information and
agreed with the Company to keep such information confidential. The Company understands and confirms that each Purchaser shall be
relying on the foregoing covenant in effecting transactions in securities of the Company. To the extent that the Company delivers
any material, non-public information to a Purchaser without such Purchaser’s consent, the Company hereby covenants and agrees
that such Purchaser shall not have any duty of confidentiality to the Company, any of its Subsidiaries, or any of their respective
officers, directors, agents, employees or Affiliates, or a duty to the Company, any of its Subsidiaries or any of their respective
officers, directors, agents, employees or Affiliates not to trade on the basis of, such material, non-public information, provided
that the Purchaser shall remain subject to applicable law. To the extent that any notice provided pursuant to any Transaction Document
constitutes, or contains, material, non-public information regarding the Company or any Subsidiaries, the Company shall simultaneously
file such notice with the Commission pursuant to a Current Report on Form 6-K. The Company understands and confirms that each Purchaser
shall be relying on the foregoing covenant in effecting transactions in securities of the Company.

 

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4.7 Use of Proceeds.
Except as set forth on Schedule 4.7, the Company shall use the net proceeds from the sale of the Securities hereunder for working
capital purposes and shall not use such proceeds: (a) for the satisfaction of any portion of the Company’s debt (other than
payment of trade payables in the ordinary course of the Company’s business and prior practices), (b) for the redemption of
any ADSs, Ordinary Shares or Ordinary Share Equivalents, (c) for the settlement of any outstanding litigation or (d) in violation
of FCPA or OFAC regulations.

 

4.8 Indemnification
of Purchasers. Subject to the provisions of this Section 4.8, the Company will indemnify and hold each Purchaser and its directors,
officers, shareholders, members, partners, employees and agents (and any other Persons with a functionally equivalent role of a
Person holding such titles notwithstanding a lack of such title or any other title), each Person who controls such Purchaser (within
the meaning of Section 15 of the Securities Act and Section 20 of the Exchange Act), and the directors, officers, shareholders,
agents, members, partners or employees (and any other Persons with a functionally equivalent role of a Person holding such titles
notwithstanding a lack of such title or any other title) of such controlling persons (each, a “Purchaser Party”) harmless
from any and all losses, liabilities, obligations, claims, contingencies, damages, costs and expenses, including all judgments,
amounts paid in settlements, court costs and reasonable attorneys’ fees and costs of investigation that any such Purchaser
Party may suffer or incur as a result of or relating to (a) any breach of any of the representations, warranties, covenants or
agreements made by the Company in this Agreement or in the other Transaction Documents or (b) any action instituted against the
Purchaser Parties in any capacity, or any of them or their respective Affiliates, by any stockholder of the Company who is not
an Affiliate of such Purchaser Party, with respect to any of the transactions contemplated by the Transaction Documents (unless
such action is solely based upon a material breach of such Purchaser Party’s representations, warranties or covenants under
the Transaction Documents or any agreements or understandings such Purchaser Party may have with any such stockholder or any violations
by such Purchaser Party of state or federal securities laws or any conduct by such Purchaser Party which is finally judicially
determined to constitute fraud, gross negligence or willful misconduct). In connection with any registration statement of the Company
providing for the resale by the Purchasers of the Warrant Shares issued and issuable upon exercise of the Warrants, the Company
will indemnify each Purchaser Party, to the fullest extent permitted by applicable law, from and against any and all losses, claims,
damages, liabilities, costs (including, without limitation, reasonable attorneys’ fees) and expenses, as incurred, arising
out of or relating to (i) any untrue or alleged untrue statement of a material fact contained in such registration statement, any
prospectus or any form of prospectus or in any amendment or supplement thereto or in any preliminary prospectus, or arising out
of or relating to any omission or alleged omission of a material fact required to be stated therein or necessary to make the statements
therein (in the case of any prospectus or supplement thereto, in the light of the circumstances under which they were made) not
misleading, except to the extent, but only to the extent, that such untrue statements or omissions are based solely upon information
regarding such Purchaser Party furnished in writing to the Company by such Purchaser Party expressly for use therein, or (ii) any
violation or alleged violation by the Company of the Securities Act, the Exchange Act or any state securities law, or any rule
or regulation thereunder in connection therewith. If any action shall be brought against any Purchaser Party in respect of which
indemnity may be sought pursuant to this Agreement, such Purchaser Party shall promptly notify the Company in writing, and the
Company shall have the right to assume the defense thereof with counsel of its own choosing reasonably acceptable to the Purchaser
Party. Any Purchaser Party shall have the right to employ separate counsel in any such action and participate in the defense thereof,
but the fees and expenses of such counsel shall be at the expense of such Purchaser Party except to the extent that (x) the employment
thereof has been specifically authorized by the Company in writing, (y) the Company has failed after a reasonable period of time
to assume such defense and to employ counsel or (z) in such action there is, in the reasonable opinion of counsel, a material conflict
on any material issue between the position of the Company and the position of such Purchaser Party, in which case the Company shall
be responsible for the reasonable fees and expenses of no more than one such separate counsel. The Company will not be liable to
any Purchaser Party under this Agreement (1) for any settlement by a Purchaser Party effected without the Company’s prior
written consent, which shall not be unreasonably withheld or delayed; or (2) to the extent, but only to the extent that a loss,
claim, damage or liability is attributable to any Purchaser Party’s breach of any of the representations, warranties, covenants
or agreements made by such Purchaser Party in this Agreement or in the other Transaction Documents. The indemnification required
by this Section 4.8 shall be made by periodic payments of the amount thereof during the course of the investigation or defense,
as and when bills are received or are incurred. The indemnity agreements contained herein shall be in addition to any cause of
action or similar right of any Purchaser Party against the Company or others and any liabilities the Company may be subject to
pursuant to law.

 

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4.9 Reservation
of ADSs and Ordinary Shares. As of the date hereof, the Company has reserved and the Company shall continue to reserve and
keep available at all times, free of preemptive rights, a sufficient number of ADSs and Ordinary Shares for the purpose of enabling
the Company to issue ADSs and Ordinary Shares pursuant to this Agreement and Warrant Shares pursuant to any exercise of the Warrants.

 

4.10 Listing of
ADSs. The Company hereby agrees to use best efforts to maintain the listing or quotation of ADSs on the Trading Market on which
it is currently listed, and concurrently with the Closing, the Company shall apply to list or quote all of the ADSs and Warrant
ADSs on such Trading Market and promptly secure the listing of all of the ADSs and Warrant ADSs on such Trading Market. The Company
further agrees, if the Company applies to have the ADSs or Ordinary Shares traded on any other Trading Market, it will then include
in such application all of the ADSs and Warrant ADSs, and will take such other action as is necessary to cause all of the ADSs
and Warrant ADSs to be listed or quoted on such other Trading Market as promptly as possible. The Company will then take all action
reasonably necessary to continue the listing and trading of its ADSs on a Trading Market and will comply in all respects with the
Company’s reporting, filing and other obligations under the bylaws or rules of the Trading Market. The Company agrees to
use its reasonable best efforts to maintain the eligibility of the ADSs for electronic transfer through the Depository Trust Company
or another established clearing corporation, including, without limitation, by timely payment of fees to the Depository Trust Company
or such other established clearing corporation in connection with such electronic transfer.

 

4.11 Subsequent
Equity Sales. From the date hereof until 30 days after the Closing Date, neither the Company nor any Subsidiary shall issue,
enter into any agreement to issue or announce the issuance or proposed issuance of any ADSs, Ordinary Shares or Ordinary Share
Equivalents; provided, however that this Section 4.11 shall not apply in respect to an Exempt Issuance.

 

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4.12 Equal Treatment
of Purchasers. No consideration (including any modification of any Transaction Document) shall be offered or paid to any Person
to amend or consent to a waiver or modification of any provision of the Transaction Documents unless the same consideration is
also offered to all of the parties to the Transaction Documents. For clarification purposes, this provision constitutes a separate
right granted to each Purchaser by the Company and negotiated separately by each Purchaser, and is intended for the Company to
treat the Purchasers as a class and shall not in any way be construed as the Purchasers acting in concert or as a group with respect
to the purchase, disposition or voting of Securities or otherwise.

 

4.13 Certain Transactions
and Confidentiality. Each Purchaser, severally and not jointly with the other Purchasers, covenants that neither it nor any
Affiliate acting on its behalf or pursuant to any understanding with it will execute any purchases or sales, including Short Sales
of any of the Company’s securities during the period commencing with the execution of this Agreement and ending at such time
that the transactions contemplated by this Agreement are first publicly announced pursuant to the initial press release as described
in Section 4.4. Each Purchaser, severally and not jointly with the other Purchasers, covenants that until such time as the transactions
contemplated by this Agreement are publicly disclosed by the Company pursuant to the initial press release as described in Section
4.4, such Purchaser will maintain the confidentiality of the existence and terms of this transaction and the information included
in the Disclosure Schedules. Notwithstanding the foregoing and notwithstanding anything contained in this Agreement to the contrary,
the Company expressly acknowledges and agrees that (i) no Purchaser makes any representation, warranty or covenant hereby that
it will not engage in effecting transactions in any securities of the Company after the time that the transactions contemplated
by this Agreement are first publicly announced pursuant to the initial press release as described in Section 4.4, (ii) no Purchaser
shall be restricted or prohibited from effecting any transactions in any securities of the Company in accordance with applicable
securities laws from and after the time that the transactions contemplated by this Agreement are first publicly announced pursuant
to the initial press release as described in Section 4.4 and (iii) no Purchaser shall have any duty of confidentiality or duty
not to trade in the securities of the Company to the Company or its Subsidiaries after the issuance of the initial press release
as described in Section 4.4. Notwithstanding the foregoing, in the case of a Purchaser that is a multi-managed investment vehicle
whereby separate portfolio managers manage separate portions of such Purchaser’s assets and the portfolio managers have no
direct knowledge of the investment decisions made by the portfolio managers managing other portions of such Purchaser’s assets,
the covenant set forth above shall only apply with respect to the portion of assets managed by the portfolio manager that made
the investment decision to purchase the Securities covered by this Agreement.

 

4.14 Lock-Up.
The Company shall not amend, modify, waive or terminate any provision of any of the Lock-Up Agreements except to extend the term
of the lock-up period and shall enforce the provisions of each Lock-Up Agreement in accordance with its terms. If any officer or
director that is a party to a Lock-Up Agreement breaches any provision of a Lock-Up Agreement, the Company shall promptly use its
best efforts to seek specific performance of the terms of such Lock-Up Agreement.

 

4.15 Exercise Procedures.
The form of Notice of Exercise included in the Warrants set forth the totality of the procedures required of the Purchasers in
order to exercise the Warrants. No additional legal opinion, other information or instructions shall be required of the Purchasers
to exercise their Warrants. Without limiting the preceding sentences, no ink-original Notice of Exercise shall be required, nor
shall any medallion guarantee (or other type of guarantee or notarization) of any Notice of Exercise form be required in order
to exercise the Warrants. The Company shall honor exercises of the Warrants and shall deliver Warrant Shares in accordance with
the terms, conditions and time periods set forth in the Transaction Documents.

 

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4.16 Form D; Blue
Sky Filings. The Company agrees to timely file a Form D with respect to the Warrant and Warrant Shares as required under Regulation
D. The Company shall take such action as the Company shall reasonably determine is necessary in order to obtain an exemption for,
or to qualify the Warrant and Warrant Shares for, sale to the Purchasers at the Closing under applicable securities or “Blue
Sky” laws of the states of the United States, and shall provide evidence of such actions promptly upon request of any Purchaser.

 

ARTICLE V.

MISCELLANEOUS

 

5.1 Termination.
This Agreement may be terminated by any Purchaser, as to such Purchaser’s obligations hereunder only and without any effect
whatsoever on the obligations between the Company and the other Purchasers, by written notice to the other parties, if the Closing
has not been consummated on or before the fifth (5th) Trading Day following the date hereof; provided, however,
that no such termination will affect the right of any party to sue for any breach by any other party (or parties).

 

5.2 Fees and Expenses.
Except as expressly set forth in the Transaction Documents to the contrary, each party shall pay the fees and expenses of its advisers,
counsel, accountants and other experts, if any, and all other expenses incurred by such party incident to the negotiation, preparation,
execution, delivery and performance of this Agreement. The Company shall pay all Depositary fees (including, without limitation,
any fees required for same-day processing of any instruction letter delivered by the Company and any exercise notice delivered
by a Purchaser). The Company shall pay stamp taxes and other taxes and duties levied in connection with the delivery of any Securities
to the Purchasers and shall reimburse the Purchasers for any fees charged to Purchasers by the Depositary in connection with holding
the ADSs.

 

5.3 Entire Agreement.
The Transaction Documents, together with the exhibits and schedules thereto, the Prospectus and the Prospectus Supplement, contain
the entire understanding of the parties with respect to the subject matter hereof and thereof and supersede all prior agreements
and understandings, oral or written, with respect to such matters, which the parties acknowledge have been merged into such documents,
exhibits and schedules.

 

5.4 Notices.
Any and all notices or other communications or deliveries required or permitted to be provided hereunder shall be in writing and
shall be deemed given and effective on the earliest of: (a) the date of transmission, if such notice or communication is delivered
via facsimile or email attachment at the facsimile number or email address as set forth on the signature pages attached hereto
at or prior to 5:30 p.m. (New York City time) on a Trading Day, (b) the next Trading Day after the date of transmission, if such
notice or communication is delivered via facsimile or email attachment at the facsimile number or email address as set forth on
the signature pages attached hereto on a day that is not a Trading Day, or later than 5:30 p.m. (New York City time) on any Trading
Day, (c) the second (2nd) Trading Day following the date of mailing, if sent by U.S. nationally recognized overnight
courier service or (d) upon actual receipt by the party to whom such notice is required to be given. The address for such notices
and communications shall be as set forth on the signature pages attached hereto. To the extent that any notice provided pursuant
to any Transaction Document constitutes, or contains, material, non-public information regarding the Company or any Subsidiaries,
the Company shall simultaneously file such notice with the Commission pursuant to a Current Report on Form 6-K.

 

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5.5 Amendments;
Waivers. No provision of this Agreement may be waived, modified, supplemented or amended except in a written instrument signed,
in the case of an amendment, by the Company and Purchasers which purchased at least 50.1% in interest of the Shares based on the
initial Subscription Amounts hereunder or, in the case of a waiver, by the party against whom enforcement of any such waived provision
is sought, provided that if any amendment, modification or waiver disproportionately and adversely impacts a Purchaser (or group
of Purchasers), the consent of such disproportionately impacted Purchaser (or group of Purchasers) shall also be required. No waiver
of any default with respect to any provision, condition or requirement of this Agreement shall be deemed to be a continuing waiver
in the future or a waiver of any subsequent default or a waiver of any other provision, condition or requirement hereof, nor shall
any delay or omission of any party to exercise any right hereunder in any manner impair the exercise of any such right. Any proposed
amendment or waiver that disproportionately, materially and adversely affects the rights and obligations of any Purchaser relative
to the comparable rights and obligations of the other Purchasers shall require the prior written consent of such adversely affected
Purchaser, Any amendment effected in accordance with this Section 5.5 shall be binding upon each Purchaser and holder of Securities
and the Company.

 

5.6 Headings.
The headings herein are for convenience only, do not constitute a part of this Agreement and shall not be deemed to limit or affect
any of the provisions hereof.

 

5.7 Successors and
Assigns. This Agreement shall be binding upon and inure to the benefit of the parties and their successors and permitted assigns.
The Company may not assign this Agreement or any rights or obligations hereunder without the prior written consent of each Purchaser
(other than by merger). Any Purchaser may assign any or all of its rights under this Agreement to any Person to whom such Purchaser
assigns or transfers any Securities, provided that such transferee agrees in writing to be bound, with respect to the transferred
Securities, by the provisions of the Transaction Documents that apply to the “Purchasers.”

 

5.8 No Third-Party
Beneficiaries. This Agreement is intended for the benefit of the parties hereto and their respective successors and permitted
assigns and is not for the benefit of, nor may any provision hereof be enforced or waived by, any other Person, except as otherwise
set forth in Section 4.8 and this Section 5.8.

 

5.9 Governing Law.
All questions concerning the construction, validity, enforcement and interpretation of the Transaction Documents shall be governed
by and construed and enforced in accordance with the internal laws of the State of New York, without regard to the principles of
conflicts of law thereof. Each party agrees that all legal Proceedings concerning the interpretations, enforcement and defense
of the transactions contemplated by this Agreement and any other Transaction Documents (whether brought against a party hereto
or its respective affiliates, directors, officers, shareholders, partners, members, employees or agents) shall be commenced exclusively
in the state and federal courts sitting in the City of New York. Each party hereby irrevocably submits to the exclusive jurisdiction
of the state and federal courts sitting in the City of New York, Borough of Manhattan for the adjudication of any dispute hereunder
or in connection herewith or with any transaction contemplated hereby or discussed herein (including with respect to the enforcement
of any of the Transaction Documents), and hereby irrevocably waives, and agrees not to assert in any Action or Proceeding, any
claim that it is not personally subject to the jurisdiction of any such court, that such Action or Proceeding is improper or is
an inconvenient venue for such Proceeding. Each party hereby irrevocably waives personal service of process and consents to process
being served in any such Action or Proceeding by mailing a copy thereof via registered or certified mail or overnight delivery
(with evidence of delivery) to such party at the address in effect for notices to it under this Agreement and agrees that such
service shall constitute good and sufficient service of process and notice thereof. Nothing contained herein shall be deemed to
limit in any way any right to serve process in any other manner permitted by law. If any party shall commence an Action or Proceeding
to enforce any provisions of the Transaction Documents, then, in addition to the obligations of the Company under Section 4.8,
the prevailing party in such Action or Proceeding shall be reimbursed by the non-prevailing party for its reasonable attorneys’
fees and other costs and expenses incurred with the investigation, preparation and prosecution of such Action or Proceeding.

 

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5.10 Survival.
The representations and warranties contained herein shall survive the Closing and the delivery of the Securities.

 

5.11 Execution.
This Agreement may be executed in two or more counterparts, all of which when taken together shall be considered one and the same
agreement and shall become effective when counterparts have been signed by each party and delivered to each other party, it being
understood that the parties need not sign the same counterpart. In the event that any signature is delivered by facsimile transmission
or by e-mail delivery of a “.pdf” format data file, such signature shall create a valid and binding obligation of the
party executing (or on whose behalf such signature is executed) with the same force and effect as if such facsimile or “.pdf”
signature page were an original thereof.

 

5.12 Severability.
If any term, provision, covenant or restriction of this Agreement is held by a court of competent jurisdiction to be invalid, illegal,
void or unenforceable, the remainder of the terms, provisions, covenants and restrictions set forth herein shall remain in full
force and effect and shall in no way be affected, impaired or invalidated, and the parties hereto shall use their commercially
reasonable efforts to find and employ an alternative means to achieve the same or substantially the same result as that contemplated
by such term, provision, covenant or restriction. It is hereby stipulated and declared to be the intention of the parties that
they would have executed the remaining terms, provisions, covenants and restrictions without including any of such that may be
hereafter declared invalid, illegal, void or unenforceable.

 

5.13 Rescission
and Withdrawal Right. Notwithstanding anything to the contrary contained in (and without limiting any similar provisions of)
any of the other Transaction Documents, whenever any Purchaser exercises a right, election, demand or option under a Transaction
Document and the Company does not timely perform its related obligations within the periods therein provided, then such Purchaser
may rescind or withdraw, in its sole discretion from time to time upon written notice to the Company, any relevant notice, demand
or election in whole or in part without prejudice to its future actions and rights; provided, however, that in the
case of a rescission of an exercise of a Warrant, the applicable Purchaser shall be required to return any ADSs subject to any
such rescinded exercise notice concurrently with the return to such Purchaser of the aggregate exercise price paid to the Company
for such ADSs and the restoration of such Purchaser’s right to acquire such shares pursuant to such Purchaser’s Warrant
(including, issuance of a replacement warrant certificate evidencing such restored right).

 

5.14 Replacement
of Securities. If any certificate or instrument evidencing any Securities is mutilated, lost, stolen or destroyed, the Company
shall issue or cause to be issued in exchange and substitution for and upon cancellation thereof (in the case of mutilation), or
in lieu of and substitution therefor, a new certificate or instrument, but only upon receipt of evidence reasonably satisfactory
to the Company of such loss, theft or destruction. The applicant for a new certificate or instrument under such circumstances shall
also pay any reasonable third-party costs (including customary indemnity) associated with the issuance of such replacement Securities.

 

    -33-

     

    

 

5.15 Remedies.
In addition to being entitled to exercise all rights provided herein or granted by law, including recovery of damages, each of
the Purchasers and the Company will be entitled to specific performance under the Transaction Documents. The parties agree that
monetary damages may not be adequate compensation for any loss incurred by reason of any breach of obligations contained in the
Transaction Documents and hereby agree to waive and not to assert in any Action for specific performance of any such obligation
the defense that a remedy at law would be adequate.

 

5.16 Payment Set
Aside. To the extent that the Company makes a payment or payments to any Purchaser pursuant to any Transaction Document or
a Purchaser enforces or exercises its rights thereunder, and such payment or payments or the proceeds of such enforcement or exercise
or any part thereof are subsequently invalidated, declared to be fraudulent or preferential, set aside, recovered from, disgorged
by or are required to be refunded, repaid or otherwise restored to the Company, a trustee, receiver or any other Person under any
law (including, without limitation, any bankruptcy law, state or federal law, common law or equitable cause of action), then to
the extent of any such restoration the obligation or part thereof originally intended to be satisfied shall be revived and continued
in full force and effect as if such payment had not been made or such enforcement or setoff had not occurred.

 

5.17 Independent
Nature of Purchasers’ Obligations and Rights. The obligations of each Purchaser under any Transaction Document are several
and not joint with the obligations of any other Purchaser, and no Purchaser shall be responsible in any way for the performance
or non-performance of the obligations of any other Purchaser under any Transaction Document. Nothing contained herein or in any
other Transaction Document, and no action taken by any Purchaser pursuant hereto or thereto, shall be deemed to constitute the
Purchasers as a partnership, an association, a joint venture or any other kind of entity, or create a presumption that the Purchasers
are in any way acting in concert or as a group with respect to such obligations or the transactions contemplated by the Transaction
Documents. Each Purchaser shall be entitled to independently protect and enforce its rights including, without limitation, the
rights arising out of this Agreement or out of the other Transaction Documents, and it shall not be necessary for any other Purchaser
to be joined as an additional party in any Proceeding for such purpose. Each Purchaser has been represented by its own separate
legal counsel in its review and negotiation of the Transaction Documents. The Company has elected to provide all Purchasers with
the same terms and Transaction Documents for the convenience of the Company and not because it was required or requested to do
so by any of the Purchasers. It is expressly understood and agreed that each provision contained in this Agreement and in each
other Transaction Document is between the Company and a Purchaser, solely, and not between the Company and the Purchasers collectively
and not between and among the Purchasers.

 

5.18 Liquidated
Damages. The Company’s obligations to pay any partial liquidated damages or other amounts owing under the Transaction
Documents is a continuing obligation of the Company and shall not terminate until all unpaid partial liquidated damages and other
amounts have been paid notwithstanding the fact that the instrument or security pursuant to which such partial liquidated damages
or other amounts are due and payable shall have been canceled.

 

5.19 Saturdays,
Sundays, Holidays, etc. If the last or appointed day for the taking of any action or the expiration of any right required or
granted herein shall not be a Business Day, then such action may be taken or such right may be exercised on the next succeeding
Business Day.

 

5.20 Construction.
The parties agree that each of them and/or their respective counsel have reviewed and had an opportunity to revise the Transaction
Documents and, therefore, the normal rule of construction to the effect that any ambiguities are to be resolved against the drafting
party shall not be employed in the interpretation of the Transaction Documents or any amendments thereto. In addition, each and
every reference to share prices, ADSs and Ordinary Shares in any Transaction Document shall be subject to adjustment for reverse
and forward stock splits, stock dividends, stock combinations and other similar transactions of the ADSs or Ordinary Shares that
occur after the date of this Agreement.

 

5.21 WAIVER OF
JURY TRIAL. IN ANY ACTION, SUIT, OR PROCEEDING IN ANY JURISDICTION BROUGHT BY ANY PARTY AGAINST ANY OTHER PARTY, THE PARTIES
EACH KNOWINGLY AND INTENTIONALLY, TO THE GREATEST EXTENT PERMITTED BY APPLICABLE LAW, HEREBY ABSOLUTELY, UNCONDITIONALLY, IRREVOCABLY
AND EXPRESSLY WAIVES FOREVER TRIAL BY JURY. 

 

(Signature Pages Follow)

 

    -34-

     

    

 

IN WITNESS WHEREOF,
the parties hereto have caused this Securities Purchase Agreement to be duly executed by their respective authorized signatories
as of the date first indicated above.

 

	THERAPIX BIOSCIENCES LTD.	 	Address for Notice:
	 	 	 	 
	By:	                                	 	Fax:
	 	 	 	 
	Name:	 	 	Email for Notice: 
	 	 	 	 
	Title:	 	 	 

 

With a copy to (which shall not constitute notice):

 

[REMAINDER OF PAGE INTENTIONALLY LEFT BLANK

SIGNATURE PAGE FOR PURCHASER FOLLOWS]

 

    -35-

     

    

 

[PURCHASER SIGNATURE PAGES TO THERAPIX SECURITIES
PURCHASE AGREEMENT]

 

IN WITNESS WHEREOF,
the undersigned have caused this Securities Purchase Agreement to be duly executed by their respective authorized signatories as
of the date first indicated above.

 

Name of Purchaser: ______________________

 

Signature of Authorized Signatory of
Purchaser: _______________________

 

Name of Authorized Signatory: __________________

 

Title of Authorized Signatory: ___________________

 

Email Address of Authorized Signatory:
____________________

 

Facsimile Number of Authorized Signatory: _____________________________

 

Address for Notice to Purchaser: __________________________

 

Address for Delivery of Securities to Purchaser (if not same
as address for notice): _______________

 

Subscription Amount: $______________

 

ADSs: ______________

Warrant ADSs: ____________

EIN Number: ____________

 

Lesser of maximum amount permitted pursuant to Section 2.1 and
the limitation on Beneficial Ownership and $____________

(for purposes of clarity, the amount set
forth on the immediately above line of this signature page is included in such Purchaser’s “Subscription Amount”
for purposes of this Agreement and the Transaction Documents)

 

☐ Notwithstanding anything contained
in this Agreement to the contrary, by checking this box (i) the obligations of the above-signed to purchase the securities set
forth in this Agreement to be purchased from the Company by the above-signed, and the obligations of the Company to sell such securities
to the above-signed, shall be unconditional and all conditions to Closing shall be disregarded, (ii) the Closing shall occur on
the second (2nd) Trading Day following the date of this Agreement and (iii) any condition to Closing contemplated by this Agreement
(but prior to being disregarded by clause (i) above) that required delivery by the Company or the above-signed of any agreement,
instrument, certificate or the like or purchase price (as applicable) shall no longer be a condition and shall instead be an unconditional
obligation of the Company or the above-signed (as applicable) to deliver such agreement, instrument, certificate or the like or
purchase price (as applicable) to such other party on the Closing Date.

 

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DISCLOSURE SCHEDULES TO

SECURITIES PURCHASE AGREEMENT

 

 

-37-EX-10.1

 Exhibit 10.1 

[Execution Version] 

AMENDMENT NO. 2 

AMENDMENT NO. 2, dated as of March 26, 2019 (together with all exhibits and schedules hereto, this “Amendment
No. 2” or this “Agreement”), among SYNEOS HEALTH, INC. (f/k/a INC Research Holdings, Inc.), a Delaware corporation (the “Administrative Borrower”), the
other Borrowers identified on the signature pages hereto (together with the Administrative Borrower, the “Borrowers”), the Subsidiaries of the Administrative Borrower party hereto, JPMORGAN CHASE BANK, N.A. (as successor
agent to CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH), as administrative agent and collateral agent for the Lenders (in such capacities, the “Agent”), and the other parties hereto, relating to the Credit Agreement, dated as of
August 1, 2017 (as amended by Amendment No. 1 and as amended, restated, amended and restated, supplemented or otherwise modified from time to time prior to the date hereof, the “Credit Agreement” and the Credit
Agreement as amended by this Amendment No. 2, the “Amended Credit Agreement”), among the Borrowers, the Lenders from time to time party thereto and the Agent. 

RECITALS: 
 WHEREAS,
pursuant to Section 9.02(c)(i) of the Credit Agreement, the Administrative Borrower wishes to obtain Replacement Term Loans (the “Replacement Term A Loans”), on the same terms as the Incremental Term
A Loans referred to and as defined below to (x) replace all Term A Loans outstanding immediately prior to the effectiveness of this Amendment No. 2, respectively, and (y) pay fees and expenses in connection with the foregoing, and the
Replacement Term A Lenders (as defined below) are willing to provide the Replacement Term A Loans on and subject to the terms and conditions set forth herein. 

WHEREAS, pursuant to Section 9.02(c)(ii) of the Credit Agreement, the Administrative Borrower wishes to obtain a
Replacement Revolving Facility (the “Replacement Revolving Facility” and the Revolving Loans thereunder, the “Replacement Revolving Loans”), on the same terms as the Incremental Revolving Loans
referred to and as defined below to (x) replace all Revolving Credit Commitments outstanding immediately prior to the effectiveness of this Amendment No. 2, and (y) pay fees and expenses in connection with the foregoing, and the
Replacement Revolving Lenders (as defined below) are willing to provide the Replacement Revolving Credit Commitments (as defined below) on and subject to the terms and conditions set forth herein. 

WHEREAS, (x) each of the financial institutions listed on Schedule 1-A hereto (each, a
“Replacement Term A Lender”) is willing to provide the Replacement Term A Loans the proceeds of which will be used by the Borrowers to prepay all the Term A Loans outstanding immediately prior to the Amendment No. 2
Closing Date, (the Term A Lenders holding such existing Term A Loans, the “Existing Term A Lenders”), and (y) each of the financial institutions listed on Schedule 1-B
hereto (each, a “Replacement Revolving Lender”) is willing to provide the Revolving Credit Commitments under the Replacement Revolving Facility (the “Replacement Revolving Credit Commitments”) which
will replace all Revolving Credit Commitments outstanding immediately prior to the Amendment No. 2 Closing Date (the “Existing Revolving Credit Commitments”). 

WHEREAS, pursuant to Section 2.22 of the Credit Agreement, the Borrowers have also requested that the Credit
Agreement be amended as set forth herein to provide for, among other things, (a) an increase in the principal amount of Replacement Term A Loans in an aggregate principal amount of $587,500,000 (the “Incremental Term A
Facility”), which shall be on the same terms as the Replacement Term A Loans, which Incremental Term A Facility shall be established substantially concurrently with, but immediately following, the Replacement Term A Facility and
comprise (x) Term A Loans in an 

 
aggregate amount equal to $187,500,000 to be funded on the Amendment No. 2 Closing Date (the “Amendment No. 2 Date Incremental Term A
Loans”) and (y) delayed draw Term A Loans to be made available to the Borrowers from time to time during the Delayed Draw Term A Loan Availability Period (as defined in the Amended Credit Agreement) in an aggregate amount equal to
$400,000,000 (the “Delayed Draw Term A Loans” and together with Amendment No. 2 Date Incremental Term A Loans, the “Incremental Term A Loans”) from the Term Lenders party to
this Amendment No. 2 providing Incremental Term A Loans (collectively, the “Incremental Term A Loan Lenders”) in an aggregate principal amount not to exceed the amount set forth opposite such Incremental Term A Loan
Lender’s name under the heading “Amendment No. 2 Date Incremental Term A Loan Commitment” on Schedule 2-A hereto and/or under the heading “Delayed Draw Term A Commitment” on Schedule 2-B, as applicable, (each an “Amendment No. 2 Date Incremental Term A Loan Lender” and “Delayed Draw Term A Loan Lender”,
respectively, and together with the Replacement Term A Lenders, the “Term A Loan Lenders”), and (b) an increase in the aggregate amount of Replacement Revolving Commitments in an aggregate principal amount of
$100,000,000 (the “Incremental Revolving Credit Commitment” and the Revolving Loans and Revolving Facility thereunder, the “Incremental Revolving Loans” and the
“Incremental Revolving Facility”, respectively, and the Incremental Revolving Facility together with the Replacement Revolving Facility, the “Amendment No. 2 Revolving
Facility”), which shall be on the same terms as the Replacement Revolving Facility, be established substantially concurrently with, but immediately following, the Replacement Revolving Commitments, and be provided by the Revolving
Lenders party to this Amendment No. 2 in an aggregate principal amount not to exceed the amount set forth opposite such Revolving Lender’s name under the heading “Incremental Revolving Credit Commitment” on Schedule 2-C
hereto (each an “Incremental Revolving Lender”, and together with the Replacement Revolving Lenders, the “Revolving Lenders”). 

WHEREAS, pursuant to a successor agency agreement in substantially the form set forth in Exhibit B hereto (the “Successor
Agency Agreement”) and each other document required or contemplated thereby in accordance with the terms and conditions set forth therein, the Administrative Borrower has requested that (A)(i) Credit Suisse AG, Cayman Islands Branch, as
administrative agent and collateral agent for the Lenders (in such capacities, the “Resigning Agent”), resign in each such capacity in connection with and under the Credit Agreement and (ii) JPMorgan Chase Bank, N.A.
succeed to the Resigning Agent’s duties in each such capacity (in such capacities, the “New Agent”) (each succession as described in this clause (A), the “Agency Transfer”) and (B) Credit
Suisse AG, Cayman Islands Branch, as Issuing Bank (in such capacity, the “Resigning Issuing Bank”) resign in such capacity in connection with and under the Credit Agreement (such resignation as described in this clause (B),
the “Issuing Bank Resignation”). 
 WHEREAS, (i) each of JPMorgan Chase Bank, N.A., Wells Fargo Securities,
LLC, PNC Capital Markets LLC, Merrill Lynch, Pierce, Fenner & Smith Incorporated, SunTrust Robinson Humphrey, Inc., ING Capital LLC, Fifth Third Bank, Regions Capital Markets, a division of Regions Bank, Keybank National Association, MUFG
Bank, Ltd, Barclays Bank PLC, Goldman Sachs Bank USA, TD Securities (USA) LLC, Morgan Stanley Senior Funding, Inc. and CitiBank N.A., will act as joint lead arrangers (collectively, the “Lead Arrangers”), (ii) JPMorgan Chase
Bank, N.A., Wells Fargo Securities, LLC, PNC Capital Markets LLC, Merrill Lynch, Pierce, Fenner & Smith Incorporated and SunTrust Robinson Humphrey, Inc., will act as joint bookrunners, (iii) Wells Fargo Securities, LLC, PNC Capital
Markets LLC, Merrill Lynch, Pierce, Fenner & Smith Incorporated, SunTrust Robinson Humphrey, Inc. and ING Capital LLC, will act as co-syndication agent, (iv) Fifth Third Bank, Regions Capital
Markets, a division of Regions Bank, Keybank National Association, MUFG Bank, Ltd, Barclays Bank PLC, Goldman Sachs Bank USA, TD Bank, N.A., Morgan Stanley Senior Funding, Inc. and CitiBank N.A. will asct as
co-documentation agents, in each case, for this Agreement, the Replacement Term A Loans, Replacement Revolving Commitment, Incremental Term A Loans, the Incremental Revolving Credit Commitments and the other
transactions contemplated under this Amendment No. 2. 

  
 2 

 WHEREAS, the Lenders whose signatures appear below, constituting (a) all of the Term A
Loan Lenders, (b) all of the Revolving Lenders, (c) the Required Lenders and (d) each Issuing Bank other than the Resigning Issuing Bank (in each case, under the Amended Credit Agreement), are willing to amend the Credit Agreement on
the terms and subject to the conditions set forth herein. 
 NOW THEREFORE, the parties hereto hereby agree as follows: 

SECTION 1. Defined Terms. Unless otherwise specifically defined herein, each term used herein that is defined in
the Credit Agreement has the meaning assigned to such term in the Credit Agreement. Each reference in the Credit Agreement to “this Agreement”, “hereof”, “hereunder”, “herein” and “hereby” and each
other similar reference, and each reference in any other Loan Document to “the Credit Agreement”, “thereof”, “thereunder”, “therein” or “thereby” or any other similar reference to the Credit
Agreement shall, on and from the Amendment No. 2 Closing Date, refer to the Credit Agreement as amended hereby. 
 SECTION 2.
Replacement Term A Loans and Replacement Revolving Facility. 
 (a)    Subject to and upon the terms and
conditions set forth herein: 
 (i)    each Replacement Term A Lender hereby severally agrees, on the
Amendment No. 2 Closing Date, (i) to commit to provide Replacement Term A Loans in Dollars to the Borrowers in an amount equal to the commitment amount set forth next to such Replacement Term A Lender’s name in Schedule 1-A hereto under the caption “Replacement Term A Commitment” and (ii) to fund Replacement Term A Loans to the Borrowers in the amount of its Replacement Term A Commitment, and such Replacement
Term A Commitment will terminate in full upon the funding of the related Replacement Term A Loans. Replacement Term A Loans borrowed under this Section 2 and subsequently repaid or prepaid may not be
re-borrowed. On the Amendment No. 2 Closing Date, after giving effect to the Replacement Term A Loans hereunder, (x) each Replacement Term A Lender shall be deemed to be an “Initial Term A
Lender” for all purposes under the Credit Agreement and the other Loan Documents and (y) each Replacement Term A Loan shall constitute a “Loan” and shall be deemed to be an “Initial Term A Loan” for all purposes of the
Credit Agreement and the other Loan Documents. The aggregate amount of the Replacement Term A Commitments on the Amendment No. 2 Closing Date is $962,500,000. 

(ii)    each Replacement Revolving Lender hereby severally agrees, on the Amendment No. 2 Closing
Date, (i) to commit to provide Replacement Revolving Credit Commitments to the Borrowers in an amount equal to the commitment amount set forth next to such Replacement Revolving Lender’s name in Schedule 1-B hereto under the caption
“Replacement Revolving Credit Commitment” and (ii) agrees, on the terms and subject to the conditions set forth in the Amended Credit Agreement, from the Amendment No. 2 Closing Date and from time to time thereafter until the
applicable Maturity Date (or such earlier date as the commitments shall be terminated in accordance with the Amended Credit Agreement), to fund Revolving Loans to the Borrowers up to the amount of its Replacement Revolving Credit Commitment (as such
amount may be modified from time to time in accordance with the Amended Credit Agreement). On and from the Amendment No. 2 Closing Date, after giving effect to the Replacement Revolving Commitments hereunder, (x) each Replacement Revolving
Lender shall be deemed to be an “Initial Revolving Lender” for all purposes under the Credit Agreement and the other Loan Documents and (y) the Replacement Revolving Credit Commitments and the Replacement Revolving Loans thereunder
shall be deemed to be “Initial Revolving Credit Commitments” and the Loans thereunder shall constitute a “Loan” and an “Initial Revolving Loan” for all purposes of the Credit Agreement and the other Loan Documents. The
aggregate amount of the Replacement Revolving Credit Commitments on the Amendment No. 2 Closing Date is $500,000,000. 

  
 3 

 (b)    Substantially simultaneously with the Borrowing of Replacement
Term A Loans, the Borrowers shall apply the proceeds thereof to, among other things, prepay Term A Loans of the Existing Term A Lenders outstanding immediately prior to the Amendment No. 2 Closing Date together with accrued and unpaid interest
thereon to the Amendment No. 2 Closing Date. 
 (c)    Substantially simultaneously with the Borrowing of any
Replacement Revolving Loans on the Amendment No. 2 Closing Date, the Borrowers shall apply the proceeds thereof to, among other things, prepay any Revolving Loans (and replace and cancel the Existing Revolving Credit Commitments) outstanding
immediately prior to the Amendment No. 2 Closing Date, together with accrued and unpaid interest thereon to the Amendment No. 2 Closing Date. 

(d)    The Replacement Term A Loans shall have terms identical to the Incremental Term A Loans (including as to maturity)
and will constitute Term A Loans (as defined in the Amended Credit Agreement) for all purposes under the Credit Agreement and the other Loan Documents, and the Replacement Term A Loans, the Amendment No. 2 Date Incremental Term A Loans and the
Delayed Draw Term A Loans will collectively comprise a single Class of Term A Loans. 
 (e)    The Replacement
Revolving Facility shall have terms identical to the Incremental Revolving A Facility (including as to maturity) and will constitute a Revolving Facility (as defined in the Amended Credit Agreement) for all purposes under the Credit Agreement and
the other Loan Documents, and the Replacement Revolving Loans and the Incremental Revolving Loans under the applicable Revolving Credit Commitments will collectively comprise a single Class of Revolving Loans (as defined in Amended Credit
Agreement). 
 SECTION 3. Incremental Loans. 

(a)    Subject to the terms and conditions set forth herein: 

(i)    each of the Incremental Term A Loan Lenders, as applicable, hereby severally (i) commits to
provide Amendment No. 2 Date Incremental Term A Loans and Delayed Draw Term A Loans to the Borrowers in Dollars in an amount equal to its “Amendment No. 2 Date Incremental Term A Loan Commitment” and/or to its “Delayed Draw
Term A Commitment” set forth next to such Incremental Term A Loan Lender’s name in Schedules 2-A and 2-B hereto, respectively, and
(ii) agrees (x) on the Amendment No. 2 Closing Date, to fund Amendment No. 2 Date Incremental Term A Loans to the Borrowers in the amount of its Amendment No. 2 Date Incremental Term A Loan Commitment, which Amendment No. 2
Date Incremental Term A Loan Commitment shall terminate in full upon the making of the Amendment No. 2 Date Incremental Term A Loans on the Amendment No. 2 Closing Date and (y) during the Delayed Draw Term A Loan Availability Period,
to fund Delayed Draw Term A Loans to the Borrowers in the amount of its Delayed Draw Term A Commitment (as such amount may be modified from time to time in accordance with the Amended Credit Agreement) on the terms and subject to the conditions set
forth in the Amended Credit Agreement. Amendment No. 2 Date Incremental Term A Loans and Delayed Draw Term A Loans borrowed under this Section 3 and subsequently repaid or prepaid may not be re-borrowed. On the Amendment No. 2 Closing
Date, after giving effect to the Amendment No. 2 Date Incremental Term A Loans hereunder, (x) each of the Incremental Term A Loan Lenders shall be deemed to be an “Initial Term A Lender” for all purposes under the Credit
Agreement and the other Loan Documents and (y) each Amendment No. 2 Date Incremental Term A Loan shall constitute a “Loan” and shall be deemed to be an “Initial Term A Loan” for all purposes of the Credit Agreement and
the other Loan Documents. 

  
 4 

 
The aggregate amount of the Amendment No. 2 Date Incremental Term A Loan Commitment and the Delayed Draw Term A Loan Commitments on the Amendment No. 2 Closing Date is $187,500,000 and
$400,000,000, respectively. 
 (ii)    each of the Incremental Revolving Lenders hereby severally
(i) commits to provide Incremental Revolving Credit Commitments to the Borrowers in the amount equal to its Incremental Revolving Credit Commitment set forth next to such Incremental Revolving Lender’s name in Schedule 2-C hereto under the caption “Incremental Revolving Credit Commitment” and (ii) agrees, on the terms and subject to the conditions set forth in the Amended Credit Agreement, from the Amendment
No. 2 Closing Date and from time to time thereafter until the applicable Maturity Date (or such earlier date as the commitments shall be terminated in accordance with the Amended Credit Agreement) to fund Incremental Revolving Loans to the
Borrowers up to the amount of its Revolving Credit Commitment (as such amount may be reduced from time to time in accordance with the Amended Credit Agreement). On and from the Amendment No. 2 Closing Date, after giving effect to the
Incremental Revolving Commitments hereunder, (x) each Incremental Revolving Lender shall be deemed to be an “Initial Revolving Lender” for all purposes under the Credit Agreement and the other Loan Documents and (y) the
Incremental Revolving Credit Commitments shall be deemed to be “Initial Revolving Credit Commitments” and the Incremental Revolving Loans thereunder shall constitute a “Loan” and an “Initial Revolving Loan” for all
purposes of the Credit Agreement and the other Loan Documents. The aggregate amount of the Incremental Revolving Credit Commitments as of the Amendment No. 2 Closing Date is $100,000,000. 

(b)    Substantially simultaneously with the Borrowing of Amendment No. 2 Date Incremental Term A Loans on the
Amendment No. 2 Closing Date, the Borrowers shall apply the proceeds thereof to, among other things, prepay a portion of the Term B Loans outstanding immediately prior to the Amendment No. 2 Closing Date together with accrued and unpaid
interest thereon to the Amendment No. 2 Closing Date. 
 (c)    Substantially simultaneously with the Borrowing of
any Incremental Revolving Loans on the Amendment No. 2 Closing Date, the Borrowers shall apply the proceeds thereof to, among other things, prepay a portion of the Term B Loans outstanding immediately prior to the Amendment No. 2 Closing
Date together with accrued and unpaid interest thereon to the Amendment No. 2 Closing Date. 
 (d)    Substantially
simultaneously with the Borrowing of Delayed Draw Term A Loans, the Borrowers shall (i) prepay any Term B Loans outstanding immediately prior to such date of funding and/or (ii) redeem, repay, defease or discharge all or a portion of the
Senior Unsecured Notes. 
 (e)    Each Incremental Term A Loan and each Incremental Revolving Loan constitutes an
“Incremental Loan” incurred in accordance with Section 2.22 of the Amended Credit Agreement, and with respect to such Incremental Loans: 

(i)    the Incremental Term A Loans shall have terms identical to the Replacement Term A Loans (including
as to maturity) and will constitute Term A Loans for all purposes under the Credit Agreement, and the Incremental Term A Loans and the Replacement Term A Loans will collectively comprise a single Class of Term A Loans; and 

(ii)    the Incremental Revolving Facility shall have terms identical to the Replacement Revolving Facility
(including as to maturity) and will constitute a Revolving Facility for all purposes under the Credit Agreement, and the Incremental Revolving Loans and the Replacement Revolving Loans will collectively comprise a single Class of Revolving
Loans (as defined in Amended Credit Agreement). 

  
 5 

 (f)    Effective on and at all times after the Amendment No. 2
Closing Date, the parties hereto intend to treat (i) all Replacement Term A Loans, Amendment No. 2 Date Incremental Term A Loans and Delayed Draw Term A Loans as a single class and tranche of Term A Loans and (ii) all Revolving Loans
under the Replacement Revolving Facility and Incremental Revolving Facility Loans as a single class and tranche of Revolving Loans. 

(g)    The Lenders party hereto constituting the Required Lenders (immediately prior to giving effect to the Amendment
No. 2 Date Incremental Term A Loans, Incremental Term A Facility, Delayed Draw Term A Loans and the Incremental Revolving Facility) hereby acknowledge and agree that the aggregate principal amount of Incremental Facilities, including, for the
avoidance of doubt, the Delayed Draw Term A Commitments (as defined in the Amended Credit Agreement), incurred or established pursuant to this Amendment No. 2 shall be deemed to have been incurred in compliance with the definition of
‘Incremental Cap’ and shall not reduce the amount available under clause (a)(i) of the definition of ‘Incremental Amount’ referred to in clause (a) of the definition of ‘Incremental Cap’ after giving effect to this
Amendment No. 2. Notwithstanding anything to the contrary contained herein or in the Amended Credit Agreement or any other Loan Document, the Borrowers agree that on and from the Amendment No. 2 Closing Date, solely for the purpose of
calculating any applicable ratio in connection with the incurrence of an Incremental Facility or other Indebtedness, the Delayed Draw Term A Loans shall be deemed to be fully drawn as of the date of such incurrence (to the extent there are any
commitments with respect to the Delayed Draw Term A Loans outstanding under the Amended Credit Agreement as of such date). 
 SECTION
4. Amendments to Credit Agreement; Agency Transfer. 
 (a)    On the Amendment No. 2 Closing Date, the
Borrowers, the Administrative Agent and the Lenders party hereto agree that the Credit Agreement (excluding the schedules (except as set forth in Section 4(b) and Section 4(c) below) and exhibits thereto, each of which shall remain as in
effect immediately prior to the Amendment No. 2 Closing Date) is, effective as of the Amendment No. 2 Closing Date, hereby amended to delete the stricken text (indicated textually in the same manner as the following example: stricken text ) and to add the double-underlined text (indicated textually in the same manner as the following example: double-underlined text) as set forth in the Credit Agreement attached as Exhibit
A hereto. 
 (b)    On the Amendment No. 2 Closing Date, the Borrowers, the Administrative Agent and the
Lenders party hereto agree that Schedule 1.01(d) of the Credit Agreement shall be deleted in its entirety and replaced with Schedule 1.01(d) as set forth in Exhibit C attached hereto. 

(c)    On the Amendment No. 2 Closing Date, the Borrowers, the Administrative Agent and the Lenders party hereto
agree that Schedule 1.01(e) of the Credit Agreement shall be deleted in its entirety and replaced with Schedule 1.01(e) as set forth in Exhibit D attached hereto. 

(d)    The Lenders party hereto constituting the Required Lenders (immediately prior to giving effect to the Amendment
No. 2 Date Incremental Term A Loans, Incremental Term A Facility, Delayed Draw Term A Loans and the Incremental Revolving Facility) and the Administrative Borrower hereby acknowledge and consent to the appointment of the New Agent as the
administrative agent and collateral agent under the Credit Agreement and the other Loan Documents and the other transactions contemplated by the Agency Transfer upon the effectiveness of and on the terms and conditions set forth in the Successor
Agency Agreement, which shall occur substantially concurrently with, but immediately prior to, the other transactions contemplated under this Agreement. Each Loan Party and Lender party hereto hereby waives any notice period under any Loan Document
applicable to the resignation of the Resigning Agent. 

  
 6 

 (e)    Subject to Section 2.05(i)(iii) of the Credit Agreement and
the terms and conditions of the Successor Agency Agreement, the Revolving Lenders, each Issuing Bank (other than the Resigning Issuing Bank) (in each case, immediately prior to giving effect to the Amendment No. 2 Revolving Facility) and the
Administrative Borrower hereby acknowledge the resignation of the Resigning Issuing Bank under the Credit Agreement and the other Loan Documents and the other transactions contemplated by the Issuing Bank Resignation upon the effectiveness of the
Successor Agency Agreement, which shall occur substantially concurrently with, but immediately prior to, the other transactions contemplated under this Agreement. Each Loan Party, Revolving Lender and Issuing Bank other than the Resigning Issuing
Bank hereby waives any notice period under any Loan Document applicable to the resignation of the Resigning Issuing Bank. 
 SECTION
5. Prepayment Waiver; Interest Periods. 
 (a)    Each Existing Term A Lender party hereto hereby waives any
break funding payments owing to such Lender pursuant to Section 2.16 of the Credit Agreement as a result of the prepayment or repayment of its Term A Loans with the proceeds of the Replacement Term A Loans. 

(b)    Each applicable Revolving Lender party hereto hereby waives any break funding payments owing to such Lender
pursuant to Section 2.16 of the Credit Agreement as a result of the prepayment or repayment of its applicable Loans with the proceeds of any Replacement Revolving Loans. 

SECTION 6. Representations of the Administrative Borrower. After giving effect to this
Agreement, the Administrative Borrower represents and warrants that (i) the representations and warranties of the Administrative Borrower set forth in Article 3 of the Credit Agreement will be true in all material respects on and as of
the Amendment No. 2 Closing Date; provided that (A) to the extent that any such representation or warranty expressly relates to an earlier date such representation or warranty will be true as of such earlier date (other than any
representation or warranty made pursuant to Section 3.11 of the Credit Agreement (Disclosure) and Section 3.12 of the Credit Agreement (Solvency), which shall be deemed to be made as of the date hereof, in each case as if
each reference therein to the Closing Date were a reference to the Amendment No. 2 Closing Date) and (B) if such representation or warranty is qualified by or subject to a “material respects”, “material adverse effect”,
“material adverse change” or similar term or qualification, such representation and warranty will be true in all respects and (ii) no Default or Event of Default shall have occurred and be continuing on such date. 

SECTION 7. Conditions to the Amendment No. 2 Closing Date. This Amendment No. 2 shall become a
binding agreement of the parties hereto and the agreements set forth herein, the obligations of the Replacement Term A Lenders and Incremental Term A Loan Lenders to make, as applicable, Replacement Term A Loans and/or Amendment No. 2 Date
Incremental Term A Loans, the obligations of Revolving Lenders hereto to make, as applicable, any Replacement Revolving Loans and/or Incremental Revolving Loans, the establishment by the Delayed Draw Term A Loan Lenders of the Delayed Draw Term A
Facility, and the amendments set forth in Section 4(a) shall each become effective on the date (the “Amendment No. 2 Closing Date”) on which each of the following
conditions is satisfied or waived (in addition, for the avoidance of doubt, to the satisfaction or waiver of the conditions set forth in Section 4.02 and Section 4.03 of the Amended Credit Agreement, if applicable): 

(a)    The Agent shall have received from the Administrative Borrower, each other Loan Party, each Replacement Term A
Lender, Replacement Revolving Lenders, Incremental Term A Loan Lenders and Incremental Revolving Lenders (which such lenders, taken together, shall constitute the Required Lenders), the Agent, each Revolving Lender and each Issuing Bank other than
the Resigning Issuing Bank, an executed counterpart hereof or other written confirmation (in form satisfactory to the Agent) that such party has signed a counterpart hereof; 

  
 7 

 (b)    The Agent shall have received a Borrowing Request with respect to
the Replacement Term A Loans, Amendment No. 2 Date Incremental Term A Loans and/or (if any) Revolving Loans, as applicable, not later than 2:00 p.m. (New York Time) three Business Days prior to the Amendment No. 2 Closing Date (or such
later time as is reasonably acceptable to the Agent); it is understood and agreed that any Revolving Loans made on and from the Amendment No. 2 Closing Date shall be made pro rata as between the Revolving Lenders under the Amendment No. 2
Revolving Facility which, for the avoidance of doubt, shall be made pro rata as between Revolving Lenders holding Replacement Revolving Credit Commitments and the Incremental Revolving Credit Commitments; 

(c)    The Agent shall have received a customary legal opinion of (i) Latham & Watkins LLP, in its capacity
as special counsel to the Administrative Borrower regarding matters of New York and Delaware law, (ii) Dickinson Wright PLLC, in its capacity as special Ohio counsel to the Ohio Loan Parties, (iii) DLA Piper LLP (US), in its capacity as
special New Jersey counsel to the New Jersey Loan Parties and (iv) K&L Gates LLP, in its capacity as special North Carolina counsel to the North Carolina Loan Parties, in each case, dated the Amendment No. 2 Closing Date, and addressed
to the Administrative Agent and the Lenders. 
 (d)    The Agent shall have received (i) a certificate of each Loan
Party, dated the Amendment No. 2 Closing Date, and executed by a secretary, assistant secretary or other Responsible Officer thereof, which shall (A) certify that (x) either (I) attached thereto are a true and complete copy of the
certificate or articles of incorporation, formation or organization of such Loan Party certified by the relevant authority of its jurisdiction of organization, which certificate or articles of incorporation, formation or organization have not been
amended (except as attached thereto) since the date reflected thereon or (II) there have been no changes to the certificate or articles of incorporation, formation or organization of such Loan Party since the Closing Date (or date of joinder
with respect to any Loan Party joined to Loan Documents after the Closing Date), (y) either (I) attached thereto are a true and correct copy of the bylaws or operating, management, partnership or similar agreement of such Loan Party, together
with all amendments thereto as of the Amendment No. 2 Closing Date, which by-laws or operating, management, partnership or similar agreement are in full force and effect or (II) there have been no
changes to the by-laws or operating, management, partnership or similar agreement of such Loan Party since the Closing Date (or date of joinder with respect to any Loan Party joined to Loan Documents after the
Closing Date), and (z) attached thereto are a true and complete copy of the resolutions or written consent, as applicable, of its board of directors, board of managers, sole member or other applicable governing body authorizing the execution
and delivery of this Agreement, which resolutions or consent have not been modified, rescinded or amended (other than as attached thereto) and are in full force and effect, and (B) either (I) identify by name and title and bear the signatures
of the officers, managers, directors or other authorized signatories of such Loan Party authorized to sign this Agreement or (II) certify that there have been no changes to the officers, managers, directors or other authorized signatories of
such Loan Party since the Closing Date (or date of joinder with respect to any Loan Party joined to Loan Documents after the Closing Date) and (ii) a good standing (or equivalent) certificate for such Loan Party from the relevant authority of
its jurisdiction of organization, dated as of a recent date. 
 (e)    The Lead Arrangers and the Administrative Agent
shall have received all fees and other amounts due and payable on or prior to the Amendment No. 2 Closing Date, including, pursuant to that certain agency fee letter between the Administrative Borrower and JPMorgan Chase Bank, N.A., dated as of
February 14, 2019, and to the extent invoiced, all reasonable out-of-pocket costs and expenses of the Administrative Agent required in connection with this
Amendment No. 2 pursuant to Section 9.03(a) of the Credit Agreement and the reasonable and documented fees, disbursements and other charges of one firm of counsel, Davis Polk & Wardwell LLP, plus one local
counsel in each appropriate jurisdiction; 

  
 8 

 (f)    The representations and warranties made pursuant to
Section 6 hereof are true and correct on and as of the Amendment No. 2 Closing Date; 
 (g)    The Agent shall
have received a certificate, duly executed by a Responsible Officer of the Administrative Borrower, certifying this to the satisfaction of the conditions referred to in Section 7(f) above on the Amendment No. 2 Closing Date; 

(h)    All accrued interest and any fees pursuant to Section 2.12 of the Credit Agreement owing by the Borrowers to
the Administrative Agent and the applicable Lenders as a result of the consummation of the transactions contemplated by this Agreement shall have been paid in full in accordance with Section 2.12 thereof on the Amendment No. 2 Closing
Date. 
 (i)    No later than three Business Days in advance of the Amendment No. 2 Closing Date, the
Administrative Agent and each Lender shall have received all documentation and other information reasonably requested with respect to any Loan Party in writing by any Lender at least ten Business Days in advance of the Amendment No. 2 Closing
Date, which documentation or other information is required by regulatory authorities under applicable “know your customer” and anti-money laundering rules and regulations, including the USA PATRIOT Act. 

(j)    The Administrative Agent and any Lender (to the extent applicable and requested at least ten Business Days in
advance of the Amendment No. 2 Closing Date) shall have received, at least five days prior to the Amendment No. 2 Closing Date, a certification regarding beneficial ownership as required by 31 C.F.R. § 1010.230 (the
“Beneficial Ownership Regulation”) in relation to any Borrower that qualifies as a “legal entity customer” under the Beneficial Ownership Regulation. 

SECTION 8. Governing Law. This Agreement shall be governed by and construed and interpreted in accordance with the
laws of the State of New York. 
 SECTION 9. Confirmation of Guarantees and Security Interests. By signing this
Agreement, each Loan Party hereby confirms that (a) the obligations of the Loan Parties under the Credit Agreement as modified or supplemented hereby (including with respect to the Term A Loans and Revolving Credit Commitments) and the other
Loan Documents (i) are entitled to the benefits of the guarantees and the security interests set forth or created in the Credit Agreement, the Collateral Documents and the other Loan Documents, (ii) constitute “Obligations” as
such term is defined in the Credit Agreement, subject to the qualifications and exceptions described therein, (iii) notwithstanding the effectiveness of the terms hereof, the Collateral Documents and the other Loan Documents, are, and shall
continue to be, in full force and effect and are hereby ratified and confirmed in all respects and (b) each Replacement Term A Lender, Incremental Term A Loan Lender, Incremental Revolving Lender and Replacement Revolving Lender shall be a
“Secured Party” and a “Lender” (including without limitation for purposes of the definition of “Required Lenders” contained in Section 1.01 of the Credit Agreement) for all purposes of the Credit Agreement and the
other Loan Documents. Each Loan Party ratifies and confirms that all Liens granted, conveyed, or assigned to the Agent by such Person pursuant to any Loan Document to which it is a party remain in full force and effect, are not released or reduced,
and continue to secure full payment and performance of the Secured Obligations as increased hereby, as contemplated by this Agreement. 

SECTION 10. Credit Agreement Governs. Except as expressly set forth herein, this Agreement shall not by implication or
otherwise limit, impair, constitute a waiver of or otherwise affect the rights and remedies of any Lender or the Agent under the Credit Agreement or any other Loan Document, and shall not alter, modify, amend, novate or in any way affect any of the
terms, conditions, obligations, covenants or agreements contained in the Credit Agreement or any other Loan Document, all of which are ratified and affirmed in all respects and shall continue in full force and effect. Nothing herein shall be deemed
to 

  
 9 

 
entitle any Loan Party to a future consent to, or a waiver, amendment, modification or other change of, any of the terms, conditions, obligations, covenants or agreements contained in the Credit
Agreement or any other Loan Document in similar or different circumstances. 
 SECTION 11. Waiver. Neither the Agent nor any
of its Affiliates shall be liable to the Borrowers, any other Loan Party, any Term Lender and Revolving Lender under the applicable Term Facilities and Revolving Facilities incurred and contemplated hereunder or any of their respective Affiliates,
equity holders or debt holders for any losses, costs, damages or liabilities incurred, directly or indirectly, as a result of the Agent, or any of their respective Affiliates, taking any action in accordance with any election form executed by any
Replacement Term A Lender and/or any Replacement Revolving Lender to convert its Replacement Term A Loans and/or Revolving Credit Commitments as set forth herein. 

SECTION 12. Counterparts. This Agreement may be signed in any number of counterparts, each of which shall be an
original, with the same effect as if the signatures thereto and hereto were upon the same instrument. Delivery of an executed counterpart of a signature page to this Agreement by facsimile or electronic (i.e., “pdf” or “tif”)
transmission shall be effective as delivery of a manually executed counterpart of this Agreement. 
 SECTION 13.
Miscellaneous. This Agreement shall constitute a “Refinancing Amendment” with respect to the Replacement Term A Loans and the Replacement Revolving Credit Commitments established hereunder, an “Incremental Facility
Amendment” with respect to the Incremental Term A Facility and Incremental Revolving Facility established hereunder and a “Loan Document” for all purposes of the Credit Agreement and the other Loan Documents. The provisions of this
Agreement are deemed incorporated into the Credit Agreement as if fully set forth therein. To the extent required by the Credit Agreement, each of the Administrative Borrower and the Agent hereby consent to each Replacement Term A Lender and/or
Replacement Revolving Lender that is not a Lender as of the date hereof becoming a Lender under the Credit Agreement. On the Amendment No. 2 Closing Date, each Revolving Lender’s Applicable Revolving Credit Percentage of the aggregate
amount available to be drawn under any Letter of Credit (in respect of any Letter of Credit issued in any Alternate Currency, expressed in the Dollar Equivalent thereof) shall be re-determined giving effect to
the adjustments to the Commitments referred to in this Agreement, and the participations of the Revolving Lenders shall be reallocated to reflect such re-determined amounts. 

[Remainder of page intentionally left blank] 

  
 10 

 IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be duly executed as of
the date first above written. 
  

					
	 SYNEOS HEALTH, INC., as the Administrative

Borrower

		
	By:	 	 /s/ Jason Meggs

		 	Name:	 	Jason Meggs
		 	Title:	 	Chief Financial Officer
	
	INVENTIV HEALTH COMMUNICATIONS, INC., as a Borrower
	By:	 	  

		 	Name:	 	
		 	Title:	 	
	
	SYNEOS HEALTH US, INC., as a Borrower
		
	By:	 	 /s/ Jason Meggs

		 	Name:	 	Jason Meggs
		 	Title:	 	Chief Financial Officer
	
	SYNEOS HEALTH CLINICAL, INC., as a Borrower
		
	By:	 	  

		 	Name:	 	
		 	Title:	 	
	
	 SYNEOS HEALTH, LLC,
 as
Borrower

		
	By:	 	 /s/ Jason Meggs

		 	Name:	 	Jason Meggs
		 	Title:	 	Chief Financial Officer

  
 [Signature Page
– Amendment No. 2 to Credit Agreement] 

 IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be duly executed as of
the date first above written. 
  

					
	SYNEOS HEALTH, INC., as the Administrative Borrower
		
	By:	 	  

		 	Name:	 	
		 	Title:	 	
	
	INVENTIV HEALTH COMMUNICATIONS, INC., as a Borrower
	By:	 	 /s/ Thomas E. Zajkowski

		 	Name:	 	Thomas E. Zajkowski
		 	Title:	 	Treasurer
	
	SYNEOS HEALTH US, INC., as a Borrower
		
	By:	 	  

		 	Name:	 	
		 	Title:	 	
	
	SYNEOS HEALTH CLINICAL, INC., as a Borrower
		
	By:	 	 /s/ Thomas E. Zajkowski

		 	Name:	 	Thomas E. Zajkowski
		 	Title:	 	Treasurer
	
	 SYNEOS HEALTH, LLC,
 as
Borrower

		
	By:	 	  

		 	Name:	 	
		 	Title:	 	

  
 [Signature Page
– Amendment No.2 to Credit Agreement] 

	
	ADDISON WHITNEY LLC
	ADHERIS, LLC
	ALLIDURA COMMUNICATIONS, LLC
	BIOSECTOR 2 LLC
	CADENT MEDICAL COMMUNICATIONS, LLC
	CHAMBERLAIN COMMUNICATIONS GROUP LLC
	CHANDLER CHICCO AGENCY, L.L.C.
	GERBIG, SNELL/WEISHEIMER ADVERTISING, LLC
	INCHORD HOLDING CORPORATION
	INVENTIV CLINICAL, LLC
	INVENTIV COMMERCIAL SERVICES, LLC
	INVENTIV HEALTH CLINICAL, LLC
	INVENTIV HEALTH CLINICAL LAB, INC.
	INVENTIV HEALTH CLINICAL RESEARCH SERVICES, LLC
	INVENTIV HEALTH CLINICAL SRE, LLC
	INVENTIV HEALTH CONSULTING, INC.
	INVENTIV HEALTH PUBLIC RELATIONS, LLC
	INVENTIV HEALTH RESEARCH & INSIGHTS, LLC
	INVENTIV MEDICAL COMMUNICATIONS, LLC
	LITMUS MEDICAL MARKETING SERVICES LLC
	NAVICOR GROUP, LLC
	PALIO + IGNITE, LLC
	PHARMACEUTICAL INSTITUTE, LLC
	SYNEOS HEALTH HOLDINGS, INC.
	TAYLOR STRATEGY PARTNERS, LLC
	THE SELVA GROUP, LLC

  

			
	By:	 	 /s/ Thomas E. Zajkowski

	Name:	 	Thomas E. Zajkowski
	Title:	 	Treasurer
	
	KENDLE AMERICAS INVESTMENT INC.
	KENDLE AMERICAS MANAGEMENT INC.
		
	By:	 	
                     

	Name:	 	
	Title:	 	

  
 [Signature Page
– Amendment No. 2 to Credit Agreement] 

	
	ADDISON WHITNEY LLC
	ADHERIS, LLC
	ALLIDURA COMMUNICATIONS, LLC
	BIOSECTOR 2 LLC
	CADENT MEDICAL COMMUNICATIONS, LLC
	CHAMBERLAIN COMMUNICATIONS GROUP LLC
	CHANDLER CHICCO AGENCY, L.L.C.
	GERBIG, SNELL/WEISHEIMER ADVERTISING, LLC
	INCHORD HOLDING CORPORATION
	INVENTIV CLINICAL, LLC
	INVENTIV COMMERCIAL SERVICES, LLC
	INVENTIV HEALTH CLINICAL, LLC
	INVENTIV HEALTH CLINICAL LAB, INC.
	INVENTIV HEALTH CLINICAL RESEARCH SERVICES, LLC
	INVENTIV HEALTH CLINICAL SRE, LLC
	INVENTIV HEALTH CONSULTING, INC.
	INVENTIV HEALTH PUBLIC RELATIONS, LLC
	INVENTIV HEALTH RESEARCH & INSIGHTS, LLC
	INVENTIV MEDICAL COMMUNICATIONS, LLC
	LITMUS MEDICAL MARKETING SERVICES LLC
	NAVICOR GROUP, LLC
	PALIO + IGNITE, LLC
	PHARMACEUTICAL INSTITUTE, LLC
	SYNEOS HEALTH HOLDINGS, INC.
	TAYLOR STRATEGY PARTNERS, LLC
	THE SELVA GROUP, LLC

  

			
	By:	 	  

	Name:	 	
	Title:	 	
	
	KENDLE AMERICAS INVESTMENT INC.
	KENDLE AMERICAS MANAGEMENT INC.
		
	By:	 	 /s/ Alistair MacDonald

	Name:	 	Alistair MacDonald
	Title:	 	President and Chief Executive Officer

  
 [Signature Page
– Amendment No. 2 to Credit Agreement] 

					
	JPMORGAN CHASE BANK, N.A.
	 as Agent and Lender

		
	By:	 	 /s/ John Kushnerick

		 	Name:	 	John Kushnerick
		 	Title:	 	Executive Director

  
 [Signature Page
– Amendment No. 2 to Credit Agreement] 

 
					
	 JPMORGAN CHASE BANK, N.A. 

        as Issuing Bank

		
	By:	 	 /s/ Antje Focke

		 	Name:	 	Antje Focke
		 	Title:	 	Executive Director

  
 [Signature Page
– Amendment No. 2 to Credit Agreement] 

 
					
	CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH,
	        as Lender
		
	By:	 	 /s/ Vipul Dhadda

		 	Name:	 	Vipul Dhadda
		 	Title:	 	Authorized Signatory
		
	By:	 	 /s/ Joan Park

		 	Name:	 	Joan Park
		 	Title:	 	Authorized Signatory

  
 [Signature Page
– Amendment No. 2 to Credit Agreement] 

 
					
	Citibank, N.A.,
	        as Lender
		
	By:	 	 /s/ Alvaro De Velasco

		 	Name:	 	Alvaro De Velasco
		 	Title:	 	Vice President

  
 [Signature Page
– Amendment No. 2 to Credit Agreement] 

 
					
	WELLS FARGO BANK, NATIONAL ASSOCIATION,
	        as Lender and Issuing Bank
		
	By:	 	 /s/ Christine Gardiner

		 	Name:	 	Christine Gardiner
		 	Title:	 	Director

  
 [Signature Page
– Amendment No. 2 to Credit Agreement] 

 
					
	MUFG BANK, Ltd.
	        as Lender
		
	By:	 	 /s/ Teuta Ghilaga

		 	Name:	 	Teuta Ghilaga
		 	Title:	 	Director

  
 [Signature Page
– Amendment No. 2 to Credit Agreement] 

 
					
	FIFTH THIRD BANK,
	        as Lender
		
	By:	 	 /s/ Ellie Robertson

		 	Name:	 	Ellie Robertson
		 	Title:	 	Officer

  
 [Signature Page
– Amendment No. 2 to Credit Agreement] 

 
					
	The Huntington National Bank,
	        as Lender
		
	By:	 	 /s/ Joseph D. Hricovsky

		 	Name:	 	Joseph D. Hricovsky
		 	Title:	 	Senior Vice President

  
 [Signature Page
– Amendment No. 2 to Credit Agreement] 

 
					
	First National Bank of Pennsylvania,
	        as Lender
		
	By:	 	 /s/ Michael Kelly

		 	Name:	 	Michael Kelly
		 	Title:	 	Senior Vice President

  
 [Signature Page
– Amendment No. 2 to Credit Agreement] 

 
					
	PNC BANK, NATIONAL ASSOCIATION,
	      as Lender and Issuing Bank
		
	By:	 	 /s/ Dawn Kondrat

		 	Name:	 	Dawn Kondrat
		 	Title:	 	Credit Products Specialist, SVP

  
 [Signature Page
– Amendment No. 2 to Credit Agreement] 

 
					
	Bank of America, N.A.,
	      as Lender and Issuing Bank
		
	By:	 	 /s/ H. Hope Walker

		 	Name:	 	H. Hope Walker
		 	Title:	 	Senior Vice President

  
 [Signature Page
– Amendment No. 2 to Credit Agreement] 

 
					
	SUNTRUST BANK,
	        as Lender
		
	By:	 	 /s/ John Cappellari

		 	Name:	 	John Cappellari
		 	Title:	 	Director

  
 [Signature Page
– Amendment No. 2 to Credit Agreement] 

 
					
	Barclays Bank PLC,
	        as Lender
		
	By:	 	 /s/ Ronnie Glenn

		 	Name:	 	Ronnie Glenn
		 	Title:	 	Director

  
 [Signature Page
– Amendment No. 2 to Credit Agreement] 

 
					
	MORGAN STANLEY SENIOR FUNDING, INC.,
	        as Lender
		
	By:	 	 /s/ Michael King

		 	Name:	 	Michael King
		 	Title:	 	Vice President

  
 [Signature Page
– Amendment No. 2 to Credit Agreement] 

 
					
	MORGAN STANLEY BANK, N.A.,
	        as Lender
		
	By:	 	 /s/ Michael King

		 	Name:	 	Michael King
		 	Title:	 	Authorized Signatory

  
 [Signature Page
– Amendment No. 2 to Credit Agreement] 

 
					
	ING CAPITAL LLC,
	         as Lender and Issuing Bank
		
	By:	 	 /s/ Keith Alexander

		 	Name:	 	Keith Alexander
		 	Title:	 	Managing Director
		
	By:	 	 /s/ Andrew Isaacs

		 	Name:	 	Andrew Isaacs
		 	Title:	 	Director

  
 [Signature Page
– Amendment No. 2 to Credit Agreement] 

 
					
	REGIONS BANK,
	        as Lender
		
	By:	 	 /s/ Ned Spitzer

		 	Name:	 	Ned Spitzer
		 	Title:	 	Managing Director

  
 [Signature Page
– Amendment No. 2 to Credit Agreement] 

 
					
	 THE TORONTO-DOMINION BANK, NEW YORK BRANCH,

	as Lender
		
	By:	 	 /s/ Peter Kuo

		 	Name:	 	PETER KUO
		 	Title:	 	AUTHORIZED SIGNATORY

  
 [Signature Page
– Amendment No. 2 to Credit Agreement] 

 
					
	TD BANK, N.A.,
	        as Lender
		
	By:	 	 /s/ Alan Garson

		 	Name:	 	Alan Garson
		 	Title:	 	Senior Vice President

  
 [Signature Page
– Amendment No. 2 to Credit Agreement] 

 
					
	KEYBANK NATIONAL ASSOCIATION,
	        as Lender
		
	By:	 	 /s/ Douglas Gardner

		 	Name:	 	Douglas Gardner
		 	Title:	 	Senior Vice President

  
 [Signature Page
– Amendment No. 2 to Credit Agreement] 

 
					
	HSBC BANK USA, N.A.,
	        as Lender
		
	By:	 	 /s/ Steve Zambriczki

		 	Name:	 	Steve Zambriczki
		 	Title:	 	Vice President #22548

  
 [Signature Page
– Amendment No. 2 to Credit Agreement] 

					
	 GOLDMAN SACHS BANK USA,
	 as Lender

		
	By:	 	 /s/ Annie Carr

		 	Name:	 	Annie Carr
		 	Title:	 	Authorized Signatory

  
 [Signature Page
– Amendment No. 2 to Credit Agreement] 

 SCHEDULE 1-A 

Replacement Term A Loan Commitments 
  

					
	 Name of Replacement Term A Lender
	  	Replacement Term A Loan
Commitment	 
	 JPMorgan Chase Bank, N.A.
	  	$	91,232,227.49	 
	 Wells Fargo Bank, National Association
	  	$	75,266,587.68	 
	 SunTrust Bank
	  	$	75,266,587.68	 
	 Bank of America, N.A.
	  	$	75,266,587.68	 
	 PNC Bank, National Association
	  	$	75,266,587.68	 
	 ING Capital LLC
	  	$	59,300,947.87	 
	 Regions Bank
	  	$	50,177,725.12	 
	 KeyBank National Association
	  	$	50,177,725.12	 
	 MUFG Bank, Ltd.
	  	$	50,177,725.12	 
	 Barclays Bank PLC
	  	$	50,177,725.12	 
	 Goldman Sachs Bank USA
	  	$	50,177,725.12	 
	 TD Bank, N.A.
	  	$	50,177,725.12	 
	 Morgan Stanley Bank, N.A.
	  	$	50,177,725.12	 
	 Citibank, N.A.
	  	$	50,177,725.12	 
	 Fifth Third Bank
	  	$	41,054,502.37	 
	 The Huntington National Bank
	  	$	22,808,056.87	 
	 First National Bank of Pennsylvania
	  	$	22,808,056.87	 
	 HSBC Bank USA, N.A.
	  	$	22,808,056.87	 
		  	  
	  
	 
	 Total:
	  	$	962,500,000.00	 
		  	  
	  
	 

 SCHEDULE 1-B 

Replacement Revolving Credit Commitment 
  

					
	 Name of Replacement Revolving Lender
	  	Replacement Revolving Credit
Commitment	 
	 JPMorgan Chase Bank, N.A.
	  	$	44,233,807.27	 
	 Wells Fargo Bank, National Association
	  	$	36,492,891.00	 
	 SunTrust Bank
	  	$	36,492,891.00	 
	 Bank of America, N.A.
	  	$	36,492,891.00	 
	 PNC Bank, National Association
	  	$	36,492,891.00	 
	 Credit Suisse AG, Cayman Islands Branch
	  	$	33,333,333.33	 
	 ING Capital LLC
	  	$	28,751,974.72	 
	 Regions Bank
	  	$	24,328,594.00	 
	 KeyBank National Association
	  	$	24,328,594.00	 
	 MUFG Bank, Ltd.
	  	$	24,328,594.00	 
	 Barclays Bank PLC
	  	$	24,328,594.00	 
	 Goldman Sachs Bank USA
	  	$	24,328,594.00	 
	 The Toronto-Dominion Bank, New York Branch
	  	$	24,328,594.00	 
	 Morgan Stanley Bank, N.A.
	  	$	24,328,594.00	 
	 Citibank, N.A.
	  	$	24,328,594.00	 
	 Fifth Third Bank
	  	$	19,905,213.27	 
	 The Huntington National Bank
	  	$	11,058,451.82	 
	 First National Bank of Pennsylvania
	  	$	11,058,451.82	 
	 HSBC Bank USA, N.A.
	  	$	11,058,451.82	 
		  	  
	  
	 
	 Total:
	  	$	500,000,000.00	 
		  	  
	  
	 

 SCHEDULE 2-A 

Amendment No. 2 Date Incremental Term A Loan Commitments 
  

					
	 Name of Term A Loan Lender
	  	Amendment No. 2 Date Incremental
Term A Loan Commitment	 
	 JPMorgan Chase Bank, N.A.
	  	$	17,772,511.85	 
	 Wells Fargo Bank, National Association
	  	$	14,662,322.27	 
	 SunTrust Bank
	  	$	14,662,322.27	 
	 Bank of America, N.A.
	  	$	14,662,322.27	 
	 PNC Bank, National Association
	  	$	14,662,322.27	 
	 ING Capital LLC
	  	$	11,552,132.70	 
	 Regions Bank
	  	$	9,774,881.52	 
	 KeyBank National Association
	  	$	9,774,881.52	 
	 MUFG Bank, Ltd.
	  	$	9,774,881.52	 
	 Barclays Bank PLC
	  	$	9,774,881.52	 
	 Goldman Sachs Bank USA
	  	$	9,774,881.52	 
	 TD Bank, N.A.
	  	$	9,774,881.52	 
	 Morgan Stanley Bank, N.A.
	  	$	9,774,881.52	 
	 Citibank, N.A.
	  	$	9,774,881.52	 
	 Fifth Third Bank
	  	$	7,997,630.33	 
	 The Huntington National Bank
	  	$	4,443,127.96	 
	 First National Bank of Pennsylvania
	  	$	4,443,127.96	 
	 HSBC Bank USA, N.A.
	  	$	4,443,127.96	 
		  	  
	  
	 
	 Total:
	  	$	187,500,000.00	 
		  	  
	  
	 

 SCHEDULE 2-B 

Delayed Draw Term A Loan Commitments 
  

					
	 Name of Term A Loan Lender
	  	Delayed Draw Term A Loan
Commitment	 
	 JPMorgan Chase Bank, N.A.
	  	$	37,914,691.94	 
	 Wells Fargo Bank, National Association
	  	$	31,279,620.85	 
	 SunTrust Bank
	  	$	31,279,620.85	 
	 Bank of America, N.A.
	  	$	31,279,620.85	 
	 PNC Bank, National Association
	  	$	31,279,620.85	 
	 ING Capital LLC
	  	$	24,644,549.76	 
	 Regions Bank
	  	$	20,853,080.57	 
	 KeyBank National Association
	  	$	20,853,080.57	 
	 MUFG Bank, Ltd.
	  	$	20,853,080.57	 
	 Barclays Bank PLC
	  	$	20,853,080.57	 
	 Goldman Sachs Bank USA
	  	$	20,853,080.57	 
	 TD Bank, N.A.
	  	$	20,853,080.57	 
	 Morgan Stanley Senior Funding, Inc.
	  	$	20,853,080.57	 
	 Citibank, N.A.
	  	$	20,853,080.57	 
	 Fifth Third Bank
	  	$	17,061,611.37	 
	 The Huntington National Bank
	  	$	9,478,672.99	 
	 First National Bank of Pennsylvania
	  	$	9,478,672.99	 
	 HSBC Bank USA, N.A.
	  	$	9,478,672.99	 
		  	  
	  
	 
	 Total:
	  	$	400,000,000.00	 
		  	  
	  
	 

 SCHEDULE 2-C 

Incremental Revolving Credit Commitment 
  

					
	 Name of Revolving Lender
	  	Incremental Revolving Credit
Commitment	 
	 JPMorgan Chase Bank, N.A.
	  	$	8,846,761.45	 
	 Wells Fargo Bank, National Association
	  	$	7,298,578.20	 
	 SunTrust Bank
	  	$	7,298,578.20	 
	 Bank of America, N.A.
	  	$	7,298,578.20	 
	 PNC Bank, National Association
	  	$	7,298,578.20	 
	 Credit Suisse AG, Cayman Islands Branch
	  	$	6,666,666.67	 
	 ING Capital LLC
	  	$	5,750,394.94	 
	 Regions Bank
	  	$	4,865,718.80	 
	 KeyBank National Association
	  	$	4,865,718.80	 
	 MUFG Bank, Ltd.
	  	$	4,865,718.80	 
	 Barclays Bank PLC
	  	$	4,865,718.80	 
	 Goldman Sachs Bank USA
	  	$	4,865,718.80	 
	 The Toronto-Dominion Bank, New York Branch
	  	$	4,865,718.80	 
	 Morgan Stanley Senior Funding, Inc.
	  	$	4,865,718.80	 
	 Citibank, N.A.
	  	$	4,865,718.80	 
	 Fifth Third Bank
	  	$	3,981,042.65	 
	 The Huntington National Bank
	  	$	2,211,690.36	 
	 First National Bank of Pennsylvania
	  	$	2,211,690.36	 
	 HSBC Bank USA, N.A.
	  	$	2,211,690.36	 
		  	  
	  
	 
	 Total:
	  	$	100,000,000.00	 
		  	  
	  
	 

 EXHIBIT A 

[See attached.] 

 Table of Contents 

Page 
  

 
 CREDIT AGREEMENT 

Dated as of August 1, 2017 among 

SYNEOS HEALTH, INC. (F/K/Af/k/a INC RESEARCH HOLDINGS, INC.), 

as the Administrative Borrower, 

the other BORROWERS party hereto, 

THE FINANCIAL INSTITUTIONS PARTY HERETO, 

as Lenders, 
 JPMORGAN CHASE BANK, N.A. (as successor agent to CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH) 
 as Administrative
Agent, and 
 JPMORGAN CHASE BANK, N.A., SUNTRUST ROBINSON HUMPHREY, INC. 
 each as a Joint Lead Arranger
and a Joint Bookrunner 

CREDIT SUISSEWELLS FARGO SECURITIES (USA), LLC,  

ING CAPITAL LLC,

 GOLDMAN SACHS BANK USA, 
 MERRILL LYNCH, PIERCE, FENNER & SMITH INCORPORATED,  

MORGAN STANLEY SENIOR FUNDING, INC., BARCLAYS 
 BANK PLC, 
 CITIGROUP GLOBAL MARKETS
INC.,  

FIFTH THIRD BANK, JPMORGAN 
 CHASE BANK,
N.A., 
 PNC CAPITAL MARKETS LLC, 

each as a Joint Lead Arranger, Joint Bookrunner and Co-Syndication Agent 
 SUNTRUST BANK, 
 as a Co-Syndication
Agent 
 ING CAPITAL
LLC, 
 as a Joint
Lead Arranger and Co-Syndication Agent 
 FIFTH THIRD BANK, 
 REGIONS
CAPITAL MARKETS, A DIVISION OF REGIONS BANK,  
 SUNTRUST ROBINSON HUMPHREY, INC., KEYBANK 
 NATIONAL ASSOCIATION, 
 THEMUFG BANK OF TOYKO-MITSUBISHI UFJ, LTD. 
 and BARCLAYS 

BANK PLC, 

GOLDMAN SACHS BANK USA, WELLS 
 FARGOTD SECURITIES, (USA) LLC, 

MORGAN STANLEY SENIOR FUNDING, INC., 
  
  

  
 ii 

 Table of Contents 

Page 
  

 
 CITIBANK, N.A., 
 each as a Joint Lead
Arrangers and Joint BookrunnersArranger and a Co-Documentation Agent 
  
  

  
 iii 

 Table of Contents 

 

					
	 	  	Page	 
	ARTICLE 1 DEFINITIONS	  	 	27	 
		
	 Section 1.01. Defined Terms
	  	 	27	 
		
	 Section 1.02. Classification of Loans and Borrowings
	  	 	6471	 
		
	 Section 1.03. Terms Generally
	  	 	6471	 
		
	 Section 1.04. Accounting Terms; GAAP
	  	 	6572	 
		
	 Section 1.05. Effectuation of Transactions
	  	 	6673	 
		
	 Section 1.06. Timing of Payment or Performance
	  	 	6673	 
		
	 Section 1.07. Times of Day
	  	 	6673	 
		
	 Section 1.08. Currency Equivalents Generally
	  	 	6673	 
		
	 Section 1.09. Cashless Rollovers
	  	 	6774	 
		
	 Section 1.10. Certain Calculations and Tests
	  	 	6775	 
		
	 Section 1.11. Additional Alternate Currencies
	  	 	6976	 
		
	 Section 1.12. Divisions
	  	 	77	 
		
	ARTICLE 2 THE CREDITS	  	 	7077	 
		
	 Section 2.01. Commitments
	  	 	7077	 
		
	 Section 2.02. Loans and Borrowings
	  	 	7078	 
		
	 Section 2.03. Requests for Borrowings
	  	 	7178	 
		
	 Section 2.04. [Reserved]
	  	 	7279	 
		
	 Section 2.05. Letters of Credit
	  	 	7279	 
		
	 Section 2.06. [Reserved]
	  	 	7684	 
		
	 Section 2.07. Funding of Borrowings
	  	 	7684	 
		
	 Section 2.08. Type; Interest Elections
	  	 	7785	 
		
	 Section 2.09. Termination and Reduction of Commitments
	  	 	7886	 
		
	 Section 2.10. Repayment of Loans; Evidence of Debt
	  	 	7986	 
		
	 Section 2.11. Prepayment of Loans
	  	 	8189	 
		
	 Section 2.12. Fees
	  	 	8694	 
		
	 Section 2.13. Interest
	  	 	8796	 
		
	 Section 2.14. Alternate Rate of Interest
	  	 	8897	 
		
	 Section 2.15. Increased Costs
	  	 	8998	 
		
	 Section 2.16. Break Funding Payments
	  	 	9099	 
		
	 Section 2.17. Taxes
	  	 	9099	 
		
	 Section 2.18. Payments Generally; Allocation of Proceeds; Sharing of
Payments
	  	 	94103	 
		
	 Section 2.19. Mitigation Obligations; Replacement of Lenders
	  	 	96105	 
		
	 Section 2.20. Illegality
	  	 	97106	 

  
 i 

 Table of Contents 

(Cont.) 
  

					
	 	  	Page	 
		
	 Section 2.21. Defaulting Lenders
	  	 	98107	 
		
	 Section 2.22. Incremental Credit Extensions
	  	 	100109	 
		
	 Section 2.23. Extensions of Loans and Revolving Commitments
	  	 	104113	 
		
	 Section 2.24. Co-Borrowers
	  	 	107116	 
		
	ARTICLE 3 REPRESENTATIONS AND WARRANTIES	  	 	108117	 
		
	 Section 3.01. Organization; Powers
	  	 	108117	 
		
	 Section 3.02. Authorization; Enforceability
	  	 	108117	 
		
	 Section 3.03. Governmental Approvals; No Conflicts
	  	 	108117	 
		
	 Section 3.04. Financial Condition; No Material Adverse Effect
	  	 	109118	 
		
	 Section 3.05. Properties
	  	 	109118	 
		
	 Section 3.06. Litigation and Environmental Matters
	  	 	109118	 
		
	 Section 3.07. Compliance with Laws
	  	 	110119	 
		
	 Section 3.08. Investment Company Status
	  	 	110119	 
		
	 Section 3.09. Taxes
	  	 	110119	 
		
	 Section 3.10. ERISA
	  	 	110119	 
		
	 Section 3.11. Disclosure
	  	 	110119	 
		
	 Section 3.12. Solvency
	  	 	110120	 
		
	 Section 3.13. Capitalization and Subsidiaries
	  	 	111120	 
		
	 Section 3.14. Security Interest in Collateral
	  	 	111120	 
		
	 Section 3.15. Labor Disputes
	  	 	111120	 
		
	 Section 3.16. Federal Reserve Regulations
	  	 	111121	 
		
	 Section 3.17. OFAC; USA PATRIOT Act and FCPA
	  	 	112121	 
		
	ARTICLE 4 CONDITIONS	  	 	112121	 
		
	 Section 4.01. Closing Date
	  	 	112121	 
		
	 Section 4.02. Each Credit Extension
	  	 	115125	 
		
	 Section 4.03. Conditions to Delayed Draw Term A Loans
	  	 	125	 
		
	ARTICLE 5 AFFIRMATIVE COVENANTS	  	 	116126	 
		
	 Section 5.01. Financial Statements and Other Reports
	  	 	116126	 
		
	 Section 5.02. Existence
	  	 	119128	 
		
	 Section 5.03. Payment of Taxes
	  	 	119129	 
		
	 Section 5.04. Maintenance of Properties
	  	 	119129	 
		
	 Section 5.05. Insurance
	  	 	119129	 
		
	 Section 5.06. Inspections
	  	 	120129	 
		
	 Section 5.07. Maintenance of Book and Records
	  	 	120130	 
		
	 Section 5.08. Compliance with Laws
	  	 	120130	 

  
 ii 

 Table of Contents 

(Cont.) 
  

					
	 	  	Page	 
		
	 Section 5.09. Environmental
	  	 	120130	 
		
	 Section 5.10. Designation of Subsidiaries
	  	 	121131	 
		
	 Section 5.11. Use of Proceeds
	  	 	121131	 
		
	 Section 5.12. Covenant to Guarantee Obligations and Provide Security
	  	 	122132	 
		
	 Section 5.13. Maintenance of Ratings
	  	 	124134	 
		
	 Section 5.14. Further Assurances
	  	 	124134	 
		
	 Section 5.15. Post-Closing Covenant
	  	 	125135	 
		
	ARTICLE 6 NEGATIVE COVENANTS	  	 	125135	 
		
	 Section 6.01. Indebtedness
	  	 	125135	 
		
	 Section 6.02. Liens
	  	 	131141	 
		
	 Section 6.03. Reserved
	  	 	135145	 
		
	 Section 6.04. Restricted Payments; Restricted Debt Payments
	  	 	135145	 
		
	 Section 6.05. Burdensome Agreements
	  	 	139149	 
		
	 Section 6.06. Investments
	  	 	140151	 
		
	 Section 6.07. Fundamental Changes; Disposition of Assets
	  	 	143154	 
		
	 Section 6.08. Sale and Lease-Back Transactions
	  	 	147157	 
		
	 Section 6.09. Transactions with Affiliates
	  	 	147158	 
		
	 Section 6.10. Conduct of Business
	  	 	149160	 
		
	 Section 6.11. Amendments of or Waivers with Respect to Restricted Debt
	  	 	149160	 
		
	 Section 6.12. Fiscal Year
	  	 	149160	 
		
	 Section 6.13. Financial Covenant
	  	 	149160	 
		
	ARTICLE 7 EVENTS OF DEFAULT	  	 	150161	 
		
	 Section 7.01. Events of Default
	  	 	150161	 
		
	ARTICLE 8 THE ADMINISTRATIVE AGENT	  	 	154164	 
		
	ARTICLE 9 MISCELLANEOUS	  	 	161171	 
		
	 Section 9.01. Notices
	  	 	161171	 
		
	 Section 9.02. Waivers; Amendments
	  	 	164175	 
		
	 Section 9.03. Expenses; Indemnity
	  	 	170181	 
		
	 Section 9.04. Waiver of Claim
	  	 	171182	 
		
	 Section 9.05. Successors and Assigns
	  	 	171182	 
		
	 Section 9.06. Survival
	  	 	180191	 
		
	 Section 9.07. Counterparts; Integration; Effectiveness
	  	 	180191	 
		
	 Section 9.08. Severability
	  	 	181191	 
		
	 Section 9.09. Right of Setoff
	  	 	181191	 
		
	 Section 9.10. Governing Law; Jurisdiction; Consent to Service of Process
	  	 	181192	 

  
 iii 

 Table of Contents 

(Cont.) 
  

					
	 	  	Page	 
		
	 Section 9.11. Waiver of Jury Trial
	  	 	182193	 
		
	 Section 9.12. Headings
	  	 	183193	 
		
	 Section 9.13. Confidentiality
	  	 	183193	 
		
	 Section 9.14. No Fiduciary Duty
	  	 	184194	 
		
	 Section 9.15. Electronic Execution of Assignments and Certain Other
Documents
	  	 	184195	 
		
	 Section 9.16. Several Obligations
	  	 	185195	 
		
	 Section 9.17. USA PATRIOT Act
	  	 	185195	 
		
	 Section 9.18. Disclosure of Agent Conflicts
	  	 	185195	 
		
	 Section 9.19. Appointment for Perfection
	  	 	185195	 
		
	 Section 9.20. Interest Rate Limitation
	  	 	185196	 
		
	 Section 9.21. Intercreditor Agreements
	  	 	185196	 
		
	 Section 9.22. Conflicts
	  	 	186196	 
		
	 Section 9.23. Release of Guarantors
	  	 	186196	 
		
	 Section 9.24. Acknowledgement and Consent to Bail-In of EEA Financial
Institutions
	  	 	186197	 
		
	 Section 9.25. Judgment Currency
	  	 	187197	 

  
 iv 

 CREDIT AGREEMENT 

CREDIT AGREEMENT, dated as of August 1, 2017 (this “Agreement”), by and among Syneos Health, Inc. (f/k/a INC Research
Holdings, Inc.), a Delaware corporation (“INC Holdings” or the “Administrative Borrower”), the entities listed on Schedule I hereto (each a “Borrower” and collectively with the Administrative
Borrower, the “Borrowers”), the Lenders from time to time party hereto, JPMorgan Chase Bank, N.A. (as successor to
Credit Suisse AG, Cayman Islands Branch (“Credit Suisse”)), as administrative agent and collateral agent for the Lenders (in such capacities, the “Administrative
Agent”), and Credit Suisse Securities (USA) LLC (“CS Securities”), ING Capital LLC (“ING”), Goldman Sachs Bank USA, Merrill Lynch, Pierce, Fenner & Smith Incorporated, Morgan Stanley Senior
Funding, Inc., Barclays Bank PLC, Citigroup Global Markets Inc.,Citibank, N.A., Fifth Third Bank, JPMorgan Chase Bank, N.A., PNC Capital Markets LLC and Regions Capital Markets, a Division of Regions Bank, SunTrust Robinson Humphrey, Inc., TheMUFG Bank of Tokyo-Mitsubishi UFJ, Ltd. and Wells Fargo Securities, LLC, as joint lead arrangers and joint bookrunners (in such capacity, the
“Arrangers”). 
 RECITALS 

A. The Administrative Borrower requested on the Closing Date that the Lenders extend credit under this Agreement in the form of
(i) Initial Term A Loans in an original aggregate principal amount equal to $1,000,000,000, (ii) Initial Term B Loans in an original aggregate principal amount equal to $1,600,000,000 and (iii) an Initial Revolving Facility with an
available amount of $500,000,000, in each case, subject to increase as provided herein. 
 B. In a series of substantially contemporaneous
transactions: 
  

	 	(i)	 pursuant to the terms of the Merger Agreement, Double Eagle Parent merged (the “Closing Date
Merger”) with and into Syneos Health, Inc. (f/k/a INC Research Holdings, Inc.), with Syneos Health, Inc. as the survivor of the Closing Date Merger, 

  

	 	(ii)	 Syneos Health, LLC (f/k/a INC Research, LLC), a
Delaware limited liability company, borrowed $870,000,000 of Initial Term Loans and (A) applied $445,000,000 of the proceeds thereof to consummate the INC Refinancing and (B) loan $297,000,000 of the proceeds thereof to Syneos Health, Inc.
(f/k/a INC Research Holdings, Inc.), 

  

	 	(iii)	 Syneos Health, Inc. (f/k/a INC Research Holdings, Inc.)
(A) contributed (the “INC Contribution”) all of the issued and outstanding Capital Stock of INC Research to inVentiv Group Holdings and (B) purchased (the “inVentiv Group Holdings Share Purchase”), in
exchange for $297,000,000, one or more shares of the issued and outstanding Capital Stock of inVentiv Group Holdings (the proceeds of which $297,000,000 consideration was applied by inVentiv Group Holdings to consummate the Senior Note Redemption),

  

	 	(iv)	 Syneos Health US, Inc. (f/k/a inVentiv Health, Inc.)
borrowed $1,420,000,000 of Initial Term Loans and applied the proceeds thereof to consummate a portion of the inVentiv Refinancing, 

  

	 	(v)	 inVentiv Health Communications, Inc. borrowed $200,000,000 of Initial Term Loans and applied the proceeds
thereof to consummate a portion of the inVentiv Refinancing and 

	 	(vi)	 Syneos Health Clinical, Inc. (f/k/a inVentiv Health Clinical, Inc.) borrowed $110,000,000
of Initial Term Loans and applied the proceeds thereof to consummate a portion of the inVentiv Refinancing. 

 C. After the
Closing Date, inVentiv Group Holdings merged (the “IGH Merger”) with and into Syneos Health, Inc. (f/k/a INC Research Holdings, Inc.), with Syneos Health, Inc. as the survivor of the IGH Merger (the transactions described in
clauses B and C, the “Closing Date Merger-Related Transactions”). 
 D. Pursuant to Amendment No. 2 (as defined below), the Administrative
Borrower has requested, and the Administrative Agent, the lenders party thereto and the other agent party thereto have agreed, to amend the Credit Agreement (as defined in
Amendment No. 2) on the terms and conditions contained herein and pursuant to Amendment No. 2. 

DE
. The Lenders are willing to extend such credit to the Borrowers on the terms and subject to the conditions set forth herein. Accordingly, the parties hereto agree as follows: 

ARTICLE 1 DEFINITIONS 

Section 1.01. Defined Terms. As used in this Agreement, the following terms have the meanings specified below: 

“2018 Replacement Term A Closing Date” means the Replacement Term A Closing Date (as defined in Amendment No. 1), which
occurred on May 4, 2018. 
 “2018 Replacement Term B Closing Date” means the Replacement Term B Closing Date (as
defined in Amendment No. 1), which occurred on May 4, 2018. 
 “ABR” means, when used in reference to any Loan or
Borrowing, whether such Loan, or the Loans comprising such Borrowing, bear interest at a rate determined by reference to the Alternate Base Rate. 

“ACH” means automated clearing house transfers. 

“Additional Agreement” has the meaning assigned to such term in Article 8. 

“Additional Commitment” means any commitment hereunder added pursuant to Sections 2.22, 2.23 and/or
9.02(c). 
 “Additional Loans” means any Additional Revolving Loans and any Additional Term Loans. 

“Additional Revolving Credit Commitments” means any revolving credit commitment added pursuant to Sections 2.22,
2.23 and/or 9.02(c)(ii). 
 “Additional Revolving Credit Exposure” means, with respect to any Lender at any
time, the aggregate Outstanding Amount at such time of all Additional Revolving Loans of such Lender, plus the aggregate Outstanding Amount at such time of such Lender’s LC Exposure attributable to its Additional Revolving Credit Commitment.

 “Additional Revolving Lender” means any Lender with an Additional Revolving Credit Commitment or any Additional
Revolving Credit Exposure. 
 “Additional Revolving Loans” means any revolving loan added hereunder pursuant to Section
2.22, 2.23 and/or 9.02(c)(ii). 

  
 7 

 electronic documentation generated by use of an electronic platform) approved by the Administrative Agent
and the Administrative Borrower. 
 “Affiliated Lender Cap” has the meaning assigned to such term in
Section 9.05(g)(iv). 
 “Agent Parties” has the meaning assigned to such term in Section 9.01(d).

 “Agreement” has the meaning assigned to such term in the preamble to this Credit Agreement. 

“Agreement Currency” has the meaning assigned to such term in Section 9.25. 

“Alternate Base Rate” means, for any day, a rate per annum equal to the highest of (a) the Federal Funds Effective Rate
in effect on such day plus 0.50%, (b) to the extent ascertainable, the Eurocurrency Rate (which rate shall be calculated based upon an Interest Period of one month and shall be determined on a daily basis and, for the avoidance of doubt,
the Eurocurrency Rate for any day shall be based on the rate determined on such day at 11:00 a.m. (London time)) plus 1.00%, (c) the Prime Rate and (d) 0.00%. Any change in the Alternate Base Rate due to a change in the Prime Rate,
the Federal Funds Effective Rate or the Eurocurrency Rate, as the case may be, shall be effective from and including the effective date of such change in the Prime Rate, the Federal Funds Effective Rate or the Eurocurrency Rate, as the case may be.

 “Alternate Currency” means in the case of Revolving Loans and Letters of Credit, Canadian Dollars, Sterling, Euros,
Japanese Yen and Singapore Dollars and each other currency that is approved in accordance with Section 1.11. 

“Amendment No. 1” means the Amendment No. 1 to this
Agreement, dated as of May 4, 2018, to this Agreement.

 “Amendment No. 2” means the Amendment No. 2 to
this Agreement, dated as of March 26, 2019. 
 “Amendment No. 2 Closing Date” means March 26, 2019. 

“Applicable Country” means any country or jurisdiction in which a Foreign Subsidiary designated as a Subsidiary Guarantor
pursuant to the penultimate sentence of the definition of “Subsidiary Guarantor” is incorporated or organized. 

“Applicable Percentage” means, (a) with respect to any Term Lender of any Class, a percentage equal to a fraction the
numerator of which is the aggregate outstanding principal amount of the Term Loans and unused Additional Term Loan Commitments of such Term Lender under the applicable Class and the denominator of which is the aggregate outstanding principal amount
of the Term Loans and unused Term Commitments of all Term Lenders under the applicable Class and (b) with respect to any Revolving Lender of any Class, the percentage of the aggregate amount of the Revolving Credit Commitments of such Class
represented by such Lender’s Revolving Credit Commitment of such Class; provided that for purposes of Section 2.21 and otherwise herein (except with respect to Section 2.11(a)(ii)), when there is a Defaulting
Lender, such Defaulting Lender’s Revolving Credit Commitment shall be disregarded for any relevant calculation. In the case of clause (b), in the event that the Revolving Credit Commitments of any Class have expired or been terminated,
the Applicable Percentage of any Revolving Lender of such Class shall be determined on the basis of the Revolving Credit Exposure of such Revolving Lender attributable to its Revolving Credit Commitment of such Class, giving effect to any assignment
thereof. 

  
 9 

 “Applicable Rate” means: 

(a) with respect to any Initial Term A Loan, any Delayed Draw Term A Loan and/or
any Initial Revolving Loan, the rate per annum
applicable to the relevant Class of Loans set forth below under the caption “ABR Spread” or “Adjusted Eurocurrency Rate Spread”, as applicable; provided that until the first Adjustment Date following the completion of at least
one full Fiscal Quarter ended after the Amendment No. 2 Closing Date, the “Applicable Rate” for any Initial Term
A Loan, any Delayed Draw Term A Loan or Initial Revolving Loan shall be the applicable rate per annum set forth in Category 1 of
the applicable table set forth below: 
 (i) at any
time prior to the Replacement Term A Closing Date: 
  

									
	First Lien Leverage Ratio	  	ABR Spread for Initial
Term A Loans	 	 	Adjusted Eurocurrency
Rate Spread for Initial
Term A Loans	 
	 Category 1
	  				 			
	 Greater than 2.50 to 1.00
	  	 	0.75	% 	 	 	1.75	% 
	 Category 2
	  				 			
	 Less than or equal to 2.50 to 1.00
	  	 	0.50	% 	 	 	1.50	% 

 (ii) from and after the
Replacement Term A Closing Date: 
  

									
	First Lien Leverage Ratio	  	ABR Spread for Initial
Term A Loans,
Delayed Draw Term
A Loans and Initial
Revolving Loans	 	 	Adjusted Eurocurrency Rate
Spread for Initial Term A
Loans, Delayed Draw Term
A Loans and Initial
Revolving Loans	 
	 Category 1
	  	 	0.50	% 	 	 	1.50	% 
	 Greater than 2.50 to 1.00
	  				 			
	 Category 2
	  	 	0.25	% 	 	 	1.25	% 
	 Less than or equal to 2.50 to 1.00
	  				 			

 (a) (b) with respect to any Initial Term B Loan, the rate per annum as set forth below under the caption “ABR Spread” or
“Adjusted Eurocurrency Rate Spread”, as applicable; provided that until the first Adjustment Date following the completion of at least one full Fiscal Quarter ended after the Closing Date, the “Applicable Rate” for any
Initial Term B Loan shall be the applicable rate per annum set forth in Category 1 of the applicable table set forth below, 

  
 10 

 (i) at any time prior to the Replacement Term B Closing Date: 

 

									
	 Secured Leverage Ratio
	  	ABR Spread for Initial
Term B Loans	 	 	Adjusted Eurocurrency
Rate Spread for Initial
Term B Loans	 
	 Category 1
	  	 	1.25	% 	 	 	2.25	% 
	 Greater than 3.00 to 1.00
	  				 			
	 Category 2
	  				 			
	 Less than or equal to 3.00 to 1.00
	  	 	1.00	% 	 	 	2.00	% 

 (ii) from and after the Replacement Term B Closing Date: 

 

									
	 Secured Leverage Ratio
	  	ABR Spread for Initial
Term B Loans	 	 	Adjusted Eurocurrency
Rate Spread for Initial
Term B Loans	 
	 Category 1
	  	 	1.00	% 	 	 	2.00	% 
	 Greater than 2.75 to 1.00
	  				 			
	 Category 2
	  				 			
	 Less than or equal to 2.75 to 1.00
	  	 	0.75	% 	 	 	1.75	% 

 (c) with respect to any Initial Revolving Loan, the rate per annum applicable to the relevant Class of Loans
set forth below under the caption “ABR Spread” or “Adjusted Eurocurrency Rate Spread”, as applicable; provided that until the first Adjustment Date following the completion of at least one full Fiscal Quarter ended after the
Closing Date, the “Applicable Rate” for any Initial Revolving Loan shall be the applicable rate per annum set forth in Category 1 of the applicable table set forth below 

 

									
	First Lien Leverage Ratio	  	ABR Spread for Initial    
Revolving Loans    	 	  	Adjusted Eurocurrency
     Rate Spread for
Initial Revolving
Loans    	 
	 Category1
	  				  			
	 Greater than 2.50 to 1.00
	  	 	0.75%	 	  	 	1.75%	 
	 Category 2
	  				  			
	 Less than or equal to 2.50 to 1.00
	  	 	0.50%	 	  	 	1.50%	 
	 Category 3
	  				  			
	 Less than or equal to 2.00 to 1.00
	  	 	0.25%	 	  	 	1.25%	 

 The Applicable Rate for Initial Term A Loans, Delayed Draw
Term A Loans, Initial Term B Loans and Initial Revolving Loans shall be adjusted quarterly on a prospective basis on each Adjustment Date based upon the First Lien Leverage Ratio or Secured
Leverage Ratio, as applicable, in accordance with the tables above; provided that if financial statements are not delivered when required pursuant to Section 5.01(a) or (b), as applicable, the “Applicable Rate” for any
Initial Term A Loan, Delayed Draw Term A Loans, Initial Term B Loan or Initial Revolving Loan shall be the rate per annum set
forth above in Category 1 of the applicable table until such financial statements are delivered in compliance with Section 5.01(a) or (b), as applicable. 

  
 11 

 If (a) the corporate credit rating of the Administrative Borrower from Moody’s is Baa3 or better
or (b) the corporate family rating of the Borrower from S&P is BBB- or better, the Applicable Rate in respect of the Initial Term A Loans, Delayed Draw Term A Loans and Revolving
Loans shall be reduced by 0.25% per annum (at all levels of the grid) for so long as such rating is maintained. Each change in the Applicable Rate in respect of the Initial Term A
Loans, Delayed Draw Term A Loans and Revolving Loans resulting from a publicly announced change in the rating of the
Administrative Borrower shall be effective during the period commencing on the date of the public announcement thereof and ending on the date immediately preceding the effective date of the next change. 

“Applicable Revolving Credit Percentage” means, with respect to any Revolving Lender at any time, the percentage of the Total
Revolving Credit Commitment at such time represented by such Revolving Lender’s Revolving Credit Commitments at such time; provided that for purposes of Section 2.21 and otherwise herein (except with respect to
Section 2.11(a)(ii)), when there is a Defaulting Lender, any such Defaulting Lender’s Revolving Credit Commitment shall be disregarded in the relevant calculations. In the event that (a) the Revolving Credit Commitments of any
Class have expired or been terminated in accordance with the terms hereof (other than pursuant to Article 7), the Applicable Revolving Credit Percentage shall be recalculated without giving effect to the Revolving Credit Commitments of such
Class or (b) the Revolving Credit Commitments of all Classes have terminated (or the Revolving Credit Commitments of any Class have terminated pursuant to Article 7), the Applicable Revolving Credit Percentage shall be determined based
upon the Revolving Credit Commitments (or the Revolving Credit Commitments of such Class) most recently in effect, giving effect to any assignments thereof. 

“Approved Fund” means, with respect to any Lender, any Person (other than a natural person) that is engaged in making,
purchasing, holding or otherwise investing in commercial loans and similar extensions of credit in the ordinary course of its activities and is administered, advised or managed by (a) such Lender, (b) any Affiliate of such Lender or
(c) any entity or any Affiliate of any entity that administers, advises or manages such Lender. 
 “Arrangers” has the
meaning assigned to such term in the preamble to this Agreement; provided that as this term relates to
(a) (x) arranging the Amendment No. 1 and/or syndicating the Replacement Term A Loans (as defined in Amendment No. 1), “Arrangers” shall mean the 2018 Replacement Term A Loan Arrangers (as defined in Amendment
No. 1) and (y) arranging the Amendment No. 1 and/or syndicating the Replacement Term B Loans (as defined in Amendment No. 1), “Arrangers” shall mean the 2018 Replacement Term B Loan Arrangers (as defined in Amendment
No. 1) and (b) arranging Amendment No. 2 and syndicating the Term A Loans and Revolving Credit Commitments, “Arrangers” shall mean the ‘Lead
Arrangers’ as such term is defined in Amendment No. 2. 

“Assignment Agreement” means, collectively, each Assignment and Assumption and each Affiliated Lender Assignment and
Assumption. 
 “Assignment and Assumption” means an assignment and assumption entered into by a Lender and an assignee
(with the consent of any party whose consent is required by Section 9.05), and accepted by the Administrative Agent in the form of Exhibit A-1 or any other form (including electronic documentation generated by use of an electronic
platform) approved by the Administrative Agent and the Administrative Borrower. 
 “Available Amount” means, at any time,
an amount equal to, without duplication: 
 (a) the sum of: 

(i) the greater of $175,000,000 and 25% of Consolidated Adjusted EBITDA as of the end of the most recently ended Test Period;
plus 

  
 12 

 investment practices for cash management in Investments that are analogous to the Investments described in
clauses (a) through (g) and in this paragraph. 
 “CFC” means a “controlled foreign
corporation” within the meaning of Section 957 of the Code. 
 “CFC Holdco” means any direct or indirect Domestic
Subsidiary that has no material assets other than the Capital Stock or Indebtedness of one or more CFCs or CFC Holdcos. 
 “Change
in Law” means (a) the adoption of any law, treaty, rule or regulation after the Closing Date, (b) any change in any law, treaty, rule or regulation or in the interpretation or application thereof by any Governmental Authority after the
Closing Date or (c) compliance by any Lender or any Issuing Bank (or, for purposes of Section 2.15(b), by any lending office of such Lender or such Issuing Bank or by such Lender’s or such Issuing Bank’s holding company,
if any) with any request, guideline or directive (whether or not having the force of law) of any Governmental Authority made or issued after the Closing Date (other than any such request, guideline or directive to comply with any law, rule or
regulation that was in effect on the Closing Date). For purposes of this definition and Section 2.15, (x) the Dodd-Frank Wall Street Reform and Consumer Protection Act and all requests, rules, guidelines, requirements and directives
thereunder or issued in connection therewith or in implementation thereof and (y) all requests, rules, guidelines, requirements or directives promulgated by the Bank for International Settlements, the Basel Committee on Banking Supervision (or
any successor or similar authority) or U.S. or foreign regulatory authorities, in each case pursuant to Basel III, shall in each case described in clauses (a), (b) and (c) above, be deemed to be a Change in Law,
regardless of the date enacted, adopted, issued or implemented. 
 “Change of Control” means the earliest to occur of: 

(a) the acquisition by any Person or group (within the meaning of Section 13(d)(3) or Section 14(d)(2) of the
Exchange Act), including any group acting for the purpose of acquiring, holding or disposing of Securities (within the meaning of Rule 13d-5(b)(1) under the Exchange Act, but excluding any employee benefit plan and/or Person acting as the trustee,
agent or other fiduciary or administrator therefor), other than one or more Permitted Holders, of Capital Stock representing more than the greater of (x) 35% of the total voting power of all of the outstanding voting Capital Stock of the
Administrative Borrower and (y) the percentage of the total voting power of all of the outstanding voting Capital Stock of the Administrative Borrower owned, directly or indirectly, beneficially by the Permitted Holders; and 

(b) the occurrence of a “change of control” (or similar event, however defined) under the Senior Unsecured Notes
Indenture (or any refinancing thereof), if any amounts are outstanding thereunder. 
 Notwithstanding the foregoing, the right to acquire
voting Capital Stock (so long as such Person does not have the right to direct the voting of the Capital Stock subject to such right) or any veto power in connection with the acquisition or disposition of voting Capital Stock will not cause a party
to be a beneficial owner. 
 “Charge” means any charge, expense, cost, accrual, reserve or loss of any kind. 

“Charged Amounts” has the meaning assigned to such term in Section 9.20. 

“Class”, when used with respect to (a) any Loan or Borrowing, refers to whether such Loan, or the Loans comprising such
Borrowing, are Initial Term A Loans, Initial Term B Loans, Delayed Draw Term A Loans, Additional Term Loans of any series established
as a separate “Class” pursuant to Section 2.22, 2.23 or 9.02(c)(i), Initial Revolving Loans or Additional Revolving Loans of any series established as a separate “Class” pursuant to
Section 2.22, 2.23 or 9.02(c)(ii), (b) any Commitment, refers to whether such Commitment 

  
 18 

 is an Initial Term A Loan Commitment, Initial Term B Loan Commitment, an Additional Term Loan Commitment of
any series established as a separate “Class” pursuant to Section 2.22, 2.23 or 9.02(c)(i), an Initial Revolving Credit Commitment or an Additional Revolving Credit Commitment of any series established as a
separate “Class” pursuant to Section 2.22, 2.23 or 9.02(c)(ii), (c) any Lender, refers to whether such Lender has a Loan or Commitment of a particular Class and (d) any Revolving Credit Exposure, refers
to whether such Revolving Credit Exposure is attributable to a Revolving Credit Commitment of a particular Class (it being understood and agreed that upon funding of the Delayed Draw Term
A Loans, the Initial Term A Loans and the Delayed Draw Term A Loans shall constitute a single Class of Term Loans hereunder). 

“Closing Date” means the date on which the conditions specified in Section 4.01 are satisfied (or waived in
accordance with Section 9.02). 
 “Closing Date Material Adverse Effect” shall have the meaning assigned to the
term “Material Adverse Effect” in the Merger Agreement. 
 “Closing Date Merger” has the meaning assigned to such
term in the recitals hereto. 
 “Closing Date Merger-Related Transactions” has the meaning assigned to such term in the
recitals hereto. 
 “Code” means the Internal Revenue Code of
1986, as amended. 

“Collateral” means any and all property of any Loan Party subject (or purported to be subject) to a Lien under any Collateral
Document and any and all other property of any Loan Party, now existing or hereafter acquired, that is or becomes subject (or purported to be subject) to a Lien pursuant to any Collateral Document to secure the Secured Obligations. For the avoidance
of doubt, in no event shall “Collateral” include any Excluded Asset. 
 “Collateral and Guarantee Requirement”
means, at any time, subject to (x) the applicable limitations set forth in this Agreement and/or any other Loan Document, (y) the time periods (and extensions thereof) set forth in Section 5.12 and (z) the terms of any
Intercreditor Agreement, the requirement that the Administrative Agent shall have received in the case of any Restricted Subsidiary that is required or elects pursuant to the penultimate sentence of the definition of “Subsidiary Guarantor”
to become a Loan Party after the Closing Date (including by ceasing to be an Excluded Subsidiary), (a) a Joinder Agreement, (b) if the respective Restricted Subsidiary required to comply with the requirements set forth in this definition
pursuant to Section 5.12(a) owns registrations of or applications for U.S. Patents, Trademarks and/or Copyrights that constitute Collateral, an Intellectual Property Security Agreement, (c) a completed Perfection Certificate,
(d) UCC financing statements in appropriate form for filing in such jurisdictions as the Administrative Agent may reasonably request, (e) an executed joinder to any Intercreditor Agreement, (f) each item of Collateral that such
Restricted Subsidiary is required to deliver under Section 4.02 of the Security Agreement (which, for the avoidance of doubt, shall be delivered within the applicable time period set forth in Section 5.12(a)) and
(g) with respect to any Material Real Estate Asset, evidence of the satisfaction of the Real Estate Collateral Requirements; provided that, with respect to any Foreign Subsidiary designated as a Subsidiary Guarantor pursuant to the
penultimate sentence of the definition of “Subsidiary Guarantor”, the requirements set forth in clauses (a) through (d), (f) and (g) above shall be deemed to refer to the requirements set forth in the
parenthetical contained in such penultimate sentence. 
 “Collateral Documents” means, collectively, (i) the Security
Agreement, (ii) each Mortgage, (iii) each Intellectual Property Security Agreement, (iv) any supplement to any of the foregoing delivered to the Administrative Agent pursuant to the definition of “Collateral and Guarantee
Requirement” and (v) each other document and/or instrument pursuant to which any Loan Party grants (or purports to grant) a Lien on any Collateral as security for payment of the Secured Obligations. 

  
 19 

 “Commercial Letter of Credit” means any Letter of Credit issued for the
purpose of providing the primary payment mechanism in connection with the purchase of any materials, goods or services by the Administrative Borrower or any of its subsidiaries in the ordinary course of business of such Person. 

“Commercial Tort Claim” has the meaning set forth in Article 9 of the UCC. 

“Commitment” means, with respect to each Lender, such Lender’s Initial Term Loan Commitment, Delayed Draw Term A Commitment, Initial Revolving Credit Commitment, and Additional Commitment, as applicable, in effect as of such time.

 “Commitment Fee Rate” means, on any date (a) with respect to the Initial Revolving Credit Commitments, the
applicable rate per annum set forth below based upon the First Lien Leverage Ratio; provided that until the first Adjustment Date following the completion of at least one full Fiscal Quarter after the Closing Date, “Commitment Fee
Rate” shall be the applicable rate per annum set forth below in Category 1 and (b) with respect to Additional Revolving Credit Commitments of any Class, the rate or rates per annum specified in the applicable Refinancing Amendment,
Incremental Facility Amendment or Extension Amendment; provided that until the first Adjustment Date following the completion of at least one full Fiscal Quarter after the Closing Date, “Commitment Fee Rate” shall be the applicable
rate per annum set forth in Category 1: 
  

					
	 First Lien Leverage Ratio
	  	Commitment Fee Rate	 
	 Category 1
	  			
	 Greater than 2.50 to 1.00
	  	 	0.375	% 
	 Category 2
	  			
	 Equal to or less than 2.50 to 1.00
	  	 	0.25	% 

 The Commitment Fee Rate with respect to the Initial Revolving Credit Commitment shall be adjusted quarterly on a prospective
basis on each Adjustment Date based upon the First Lien Leverage Ratio in accordance with the table set forth above; provided that if financial statements are not delivered when required pursuant to Section 5.01(a) or (b),
as applicable, the Commitment Fee Rate shall be the rate per annum set forth above in Category 1 until such financial statements are delivered in compliance with Section 5.01(a) or (b), as applicable. 

“Commitment Schedule” means the Schedule attached hereto as Schedule 1.01(a). 

“Commodity Exchange Act” means the Commodity Exchange Act (7 U.S.C. § 1 et seq.). 

“Company Competitor” means any competitor of INC Holdings or inVentiv Group Holdings or any of their respective subsidiaries.

 “Compliance Certificate” means a Compliance Certificate substantially in the form of Exhibit C. 

“Confidential Information” has the meaning assigned to such term in Section 9.13. 

“Connection Income Taxes” means Other Connection Taxes that are imposed on or measured by net or overall gross income
(however denominated) or that are franchise Taxes or branch profit Taxes. 
 “Consolidated Adjusted EBITDA” means, with
respect to any Person on a consolidated basis for any period, the sum of: 
 (a) Consolidated Net Income for such period;
plus 

  
 20 

 severance Charge, any Charge relating to entry into a new market, any Charge relating to any
strategic initiative, any signing Charge, any retention or completion bonus, any expansion and/or relocation Charge, any Charge associated with any modification to any pension and post-retirement employee benefit plan, any software development
Charge, any Charge associated with new systems design, any implementation Charge, any project startup Charge, any Charge in connection with new operations, any Charge in connection with unused warehouse space, any Charge relating to a new contract,
any consulting Charge and/or any corporate development Charge; plus 
 (xiii) the amount of any Charge incurred or
accrued in connection with any single or one-time event, including in connection with (A) the Transactions and/or any acquisition consummated after the Closing Date (including legal, accounting and other professional fees and expenses incurred
in connection with acquisitions and other similar Investments made prior to the Closing Date), (B) the closing, consolidation or reconfiguration of any facility during such period or (C) one-time consulting costs; plus 

(d) to the extent not included in Consolidated Net Income for such period, cash actually received (or any netting arrangement
resulting in reduced cash expenditures) during such period so long as the non-cash gain relating to the relevant cash receipt or netting arrangement was deducted in the calculation of Consolidated Adjusted EBITDA (including any component definition)
pursuant to clause (h) below for any previous period and not added back; plus 
 (e) the full pro forma
“run rate” cost savings, operating expense reductions, operational improvements and synergies (collectively, “Expected Cost Savings”) (net of actual amounts realized) that are reasonably identifiable and factually
supportable (in the good faith determination of such Person, as certified by a Responsible Officer of such Person in the Compliance Certificate required by Section 5.01(c) to be delivered in connection with the financial statements for
such period) related to (A) the Transactions and (B) any permitted acquisition, Investment, Disposition, operating improvement, restructuring, cost savings initiative, any similar initiative (including the renegotiation of contracts and other
arrangements) and/or specified transaction (any such operating improvement, restructuring, cost savings initiative or similar initiative or specified transaction, a “Business Optimization Initiative”); provided that such
Expected Cost Savings under clause (B) above are expected by the Administrative Borrower in good faith to result from actions that have been taken or with respect to which substantial steps have been taken or are expected to be taken (in
the good faith determination of the Administrative Borrower) prior to the Closing Date or within 24 months of the consummation of such transaction or the taking of such initiative; it being understood and agreed for the avoidance of doubt that no
time limit shall apply in connection with any Expected Cost Savings related to the Transactions; provided, further, that the aggregate amounts added back pursuant to this clause (e) in any period shall not exceed 35% of
Consolidated Adjusted EBITDA for such period; it being understood and agreed that the 35% cap described in this further proviso shall not apply to (X) amounts that would be permitted to be included in pro forma financial statements prepared in
accordance with Regulation S-X under the Securities Act or (Y) cost savings identified in the financial model delivered to the Lead Arrangers prior to the Closing Date;
plus 
 (f) the amount of any revenue that is attributable to
services performed during such period but is not included in Consolidated Net Income for such period; it being understood that if such revenue is added back in calculating Consolidated Adjusted EBITDA for such period, such revenue shall not be
included in Consolidated Net Income in the period in which it is actually recognized; plus 
 (g) cash and non-cash losses, charges and other adjustments resulting from the application of FASB ASC Update No. 2014-09 (Revenue from Contracts with Customers (Topic 606)) effective January 1, 2018; plus

  
 23 

 (h) (g) the amount of any loss or discount on any sale of any receivable and/or
any related asset in connection with any Permitted Receivables Facility; minus 
 (i) (h) any
amount which, in the determination of Consolidated Net Income for such period, has been included for any non-cash income or non-cash gain, all as determined in accordance with GAAP (provided that if any non-cash income or non-cash gain
represents an accrual or deferred income in respect of potential cash items in any future period, such Person may determine not to deduct the relevant non-cash gain or income in the then-current period); minus 

(j) (i) the amount of any cash payment made during such period in respect of any non-cash accrual, reserve or other non-cash Charge
that is accounted for in a prior period which was added to Consolidated Net Income to determine Consolidated Adjusted EBITDA for such prior period and which does not otherwise reduce Consolidated Net Income for the current period. 

Notwithstanding anything to the contrary herein, it is agreed that for the purpose of calculating the Total Leverage Ratio, the First Lien
Leverage Ratio, the Interest Coverage Ratio, the Secured Leverage Ratio and/or the amount of any “basket” based on a percentage of Consolidated Adjusted EBITDA for any period that includes the Fiscal Quarters ended June 30,
2017, March 31, 2017, December 31, 2016 and/or September 30, 2016, (i) Consolidated Adjusted EBITDA for the Fiscal Quarter ended June 30, 2017 shall be deemed to be $171,400,000, (ii) Consolidated Adjusted
EBITDA for the Fiscal Quarter ended March 31, 2017 shall be deemed to be $178,500,000, (iii) Consolidated Adjusted EBITDA for the Fiscal Quarter ended December 31, 2016 shall be deemed to be $187,600,000 and (iv) Consolidated
Adjusted EBITDA for the Fiscal Quarter ended September 30, 2016 shall be deemed to be $178,700,000, in each case, as adjusted on a Pro Forma Basis, as applicable. 

“Consolidated First Lien Debt” means, as to any Person at any date of determination, the aggregate principal amount of
Consolidated Total Debt outstanding on such date that is secured by a Lien on the Collateral on a first priority basis. Consolidated Total Debt outstanding under this Agreement shall constitute Consolidated First Lien Debt. 

“Consolidated Interest Expense” means, with respect to any Person for any period, the sum of (a) consolidated total interest
expense of such Person and its Restricted Subsidiaries for such period, whether paid or accrued and whether or not capitalized (including (without duplication), amortization of any debt issuance cost and/or original issue discount, any premium paid
to obtain payment, financial assurance or similar bonds, any interest capitalized during construction, any non-cash interest payment, the interest component of any deferred payment obligation, the interest component of any payment under any Capital
Lease (regardless of whether accounted for as interest expense under GAAP), any commission, discount and/or other fee or charge owed with respect to any letter of credit and/or bankers’ acceptance, any fee and/or expense paid to the
Administrative Agent in connection with its services hereunder, any other bank, administrative agency (or trustee) and/or financing fee and any cost associated with any surety bond in connection with financing activities (whether amortized or
immediately expensed)) plus (b) any cash dividend paid or payable in respect of Disqualified Capital Stock during such period other than to such Person or any Loan Party, plus (c) any net losses or obligations arising from
any Hedge Agreement and/or other derivative financial instrument issued by such Person for the benefit of such Person or its subsidiaries, in each case determined on a consolidated basis for such period. For purposes of this definition, interest in
respect of any Capital Lease shall be deemed to accrue at an interest rate reasonably determined by such Person to be the rate of interest implicit in such Capital Lease in accordance with GAAP. 

  
 24 

 “Consolidated Net Income” means, with respect to any Person (the
“Subject Person”) on a consolidated basis for any period, an amount equal to the net income (loss) of such Subject Person and its Restricted Subsidiaries, determined in accordance with GAAP, but excluding: 

and (ii) to exclude any obligation, liability or indebtedness of such Person if, upon or prior to the maturity thereof, such Person has irrevocably
deposited with the proper Person in trust or escrow the necessary funds (or evidences of indebtedness) for the payment, redemption or satisfaction of such obligation, liability or indebtedness, and thereafter such funds and evidences of such
obligation, liability or indebtedness or other security so deposited are not included in the calculation of the Unrestricted Cash Amount. 

“Consolidated Working Capital” means, as at any date of determination, the excess of Current Assets over Current Liabilities.

 “Contractual Obligation” means, as applied to any Person, any provision of any Security issued by that Person or of any
indenture, mortgage, deed of trust, contract, undertaking, agreement or other instrument to which that Person is a party or by which it or any of its properties is bound or to which it or any of its properties is subject. 

“Contribution Indebtedness Amount” has the meaning assigned to such term in Section 6.01(r). 

“Control” means the possession, directly or indirectly, of the power to direct or cause the direction of the management or
policies of a Person, whether through the ability to exercise voting power, by contract or otherwise. “Controlling” and “Controlled” have meanings correlative thereto. 

“Copyright” means any and all copyrights throughout the world, including the following: (a) all rights and interests in
copyrights, works protectable by copyright whether published or unpublished, copyright registrations, copyright applications and other rights in works of authorship (including all copyrights embodied in software); (b) all renewals of any of the
foregoing; (c) all income, royalties, damages, and payments now or hereafter due and/or payable under any of the foregoing, including damages or payments for past or future infringements for any of the foregoing; (d) the right to sue for
past, present, and future infringements of any of the foregoing; and (e) all rights corresponding to any of the foregoing. 

“Credit Extension” means each of (i) the making of a Revolving Loan (other than any Letter of Credit Reimbursement Loan)
or Delayed Draw Term A Loans or (ii) the issuance, amendment, modification, renewal or extension of any Letter of Credit (other
than any such amendment, modification, renewal or extension that does not increase the Stated Amount of the relevant Letter of Credit). 

“Credit Facilities” means the Revolving Facility and the Term Facility. 

“Credit Suisse” has the meaning assigned to such term in the preamble to this Agreement. 

“CS Securities” has the meaning assigned to such term in the preamble to this Agreement. 

“Cure Amount” has the meaning assigned to such term in Section 6.13(b). 

“Cure Period” has the meaning assigned to such term in Section 6.13(b). 

“Cure Right” has the meaning assigned to such term in Section 6.13(b). 

“Current Assets” means, at any date, all assets of the Administrative Borrower and its Restricted Subsidiaries which under
GAAP would be classified as current assets (excluding any (i) cash or Cash Equivalents (including Cash and Cash Equivalents held on deposit for third parties by the Administrative Borrower and/or any Restricted Subsidiary), (ii) permitted
loans to third parties, (iii) deferred bank fees and derivative financial instruments related to Indebtedness, (iv) the current portion of current and deferred Taxes and (v) management fees receivables). 

  
 27 

 “Defaulting Lender” means any Person that has (a) defaulted in (or is
otherwise unable to perform) its obligations under this Agreement, including its obligations (x) to make a Loan within two Business Days of the date required to be made by it hereunder or (y) to fund its participation in a Letter of Credit
required to be funded by it hereunder within two Business Days of the date such obligation arose or such Loan or Letter of Credit was required to be made or funded, unless, in the case of subclause (x) above, such Person notifies the
Administrative Agent in writing that such failure is the result of such Person’s good faith determination that a condition precedent to funding (specifically identified and including the particular default, if any) has not been satisfied,
(b) notified the Administrative Agent, any Issuing Bank or the Administrative Borrower in writing that it does not intend to satisfy or perform any such obligation or has made a public statement to the effect that it does not intend to comply
with its funding or other obligations under this Agreement or under agreements in which it commits to extend credit generally (unless such writing indicates that such position is based on such Person’s good faith determination that a condition
precedent (specifically identified and including the particular default, if any) to funding a Loan cannot be satisfied), (c) failed, within two Business Days after the request of the Administrative Agent or the Administrative Borrower, to
confirm in writing that it will comply with the terms of this Agreement relating to its obligations to fund prospective Loans and participations in then outstanding Letters of Credit; provided that such Person shall cease to be a Defaulting
Lender pursuant to this clause (c) upon receipt of such written confirmation by the Administrative Agent, (d) become (or any parent company thereof has become) insolvent or been determined by any Governmental Authority having
regulatory authority over such Person or its assets, to be insolvent, or the assets or management of which has been taken over by any Governmental Authority or (e)(i) become (or any parent company thereof has become) either the subject of (A) a
bankruptcy or insolvency proceeding or (B) a Bail-In Action, (ii) has had a receiver, conservator, trustee, administrator, assignee for the benefit of creditors or similar Person charged with reorganization or liquidation of its business
or custodian, appointed for it, or (iii) has taken any action in furtherance of, or indicating its consent to, approval of or acquiescence in, any such proceeding or appointment, unless in the case of any Person subject to this clause
(e), the Administrative Borrower and the Administrative Agent have each determined that such Person intends, and has all approvals required to enable it (in form and substance satisfactory to the Administrative Borrower and the Administrative
Agent), to continue to perform its obligations hereunder; provided that no Person shall be deemed to be a Defaulting Lender solely by virtue of the ownership or acquisition of any Capital Stock in such Person or its parent by any Governmental
Authority; provided that such action does not result in or provide such Person with immunity from the jurisdiction of courts within the U.S. or from the enforcement of judgments or writs of attachment on its assets or permit such Person (or
such Governmental Authority) to reject, repudiate, disavow or disaffirm any contract or agreement to which such Person is a party. 
 “Delayed Draw Term A Commitment” means, as to each Delayed Draw Term A Lender, its obligation to make Delayed Draw Term A Loans to the Borrowers pursuant to Section 2.01(b) in an
aggregate amount not to exceed the amount set forth opposite such Term Lender’s name on Schedule 2-B to Amendment No. 2 under the caption “Delayed Draw Term A Commitment” or in the applicable Assignment and Assumption pursuant to
which such Term Lender becomes a party hereto, as applicable, as such amount may be adjusted from time to time in accordance with this Agreement (including Section 2.22). The aggregate amount of the Delayed Draw Term A Commitments as of the
Amendment No. 2 Closing Date is $400,000,000.

 “Delayed Draw Term A Commitment Termination Date” means the
earliest to occur of (i) the nine- month anniversary of the Amendment No. 2 Closing Date, (ii) the date on which the Delayed Draw Term A Commitment are reduced to $0 pursuant to Section 2.09, and (iii) the date on which all
Delayed Draw Term A Commitments then outstanding have been funded pursuant to Section 2.01(b). 

“Delayed Draw Term A Loan Availability Period” has the meaning set
forth in Section 2.01(b). 
 “Delayed Draw Term A Loan Commitment Fee” has the meaning set forth in Section 2.12(f). 

  
 29 

 “Delayed Draw Term A Loan
Funding Date” means each date on which the Delayed Draw Term A Lenders make Delayed Draw Term A Loans hereunder which, subject to the satisfaction of the conditions set forth in Section 4.03, shall be the date set forth in the notice
delivered by the Borrowers pursuant to Section 4.03(d). 
 “Delayed Draw Term A Lender” means the Term Lenders providing Delayed Draw Term A Loans under the Delayed Draw Term A Commitment.

 “Delayed Draw Term A Loans” means the Term A Loans made by
the applicable Term Lenders on a Delayed Draw Term A Loan Funding Date to the Borrowers pursuant to Section 2.01(b). 

“Deposit Account” means a demand, time, savings, passbook or like account with a bank, savings and loan association, credit
union or like organization, excluding, for the avoidance of doubt, any investment property (within the meaning of the UCC) or any account evidenced by an instrument (within the meaning of the UCC). 

“Derivative Transaction” means (a) any interest-rate transaction, including any interest-rate swap, basis swap, forward
rate agreement, interest rate option (including a cap, collar or floor), and any other instrument linked to interest rates that gives rise to similar credit risks (including when-issued securities and forward deposits accepted), (b) any
exchange-rate transaction, including any cross-currency interest-rate swap, any forward foreign-exchange contract, any currency option, and any other instrument linked to exchange rates that gives rise to similar credit risks, (c) any equity
derivative transaction, including any equity-linked swap, any equity-linked option, any forward equity-linked contract, and any other instrument linked to equities that gives rise to similar credit risk and (d) any commodity (including precious
metal) derivative transaction, including any commodity-linked swap, any commodity-linked option, any forward commodity-linked contract, and any other instrument linked to commodities that gives rise to similar credit risks; provided, that no phantom
stock or similar plan providing for payments only on account of services provided by current or former directors, officers, employees, members of management, managers or consultants of the Administrative Borrower or its subsidiaries shall
constitute a Derivative Transaction. 
 “Designated Non-Cash Consideration” means the fair market value (as determined by
the Administrative Borrower in good faith) of non-Cash consideration received by the Administrative Borrower or any Restricted Subsidiary in connection with any Disposition pursuant to Section 6.07(h) and/or Section 6.08 that
is designated as Designated Non-Cash Consideration pursuant to a certificate of a Responsible Officer of the Administrative Borrower, setting forth the basis of such valuation (which amount will be reduced by the amount of Cash or Cash Equivalents
received in connection with a subsequent sale or conversion of such Designated Non-Cash Consideration to Cash or Cash Equivalents). 

“Designated Operational FX Hedge” means any Hedge Agreement entered into for the purpose of hedging currency-related risks in
respect of the revenues, cash flows or other balance sheet items of the Administrative Borrower and/or any of its subsidiaries and designated at the time entered into (or on or prior to the Closing Date, with respect to any Hedge Agreement entered
into on or prior to the Closing Date) as a Designated Operational FX Hedge by the Administrative Borrower in a writing delivered to the Administrative Agent. 

“Disposition” or “Dispose” means the sale, lease, sublease, or other disposition of any property of any
Person. 
 “Disqualified Capital Stock” means any Capital Stock which, by its terms (or by the terms of any security into
which it is convertible or for which it is exchangeable), or upon the happening of any event, (a) matures (excluding any maturity as the result of an optional redemption by the issuer thereof) or is mandatorily redeemable (other than for
Qualified Capital Stock), pursuant to a sinking fund obligation or otherwise, or is redeemable at the option of the holder thereof (other than for Qualified Capital Stock), in whole or in part, on 

  
 30 

 or prior to 91 days following the Latest Maturity Date at the time such Capital Stock is issued (it being
understood that if any such redemption is in part, only such part coming into effect prior to 91 days following the Latest Maturity Date shall constitute Disqualified Capital Stock), (b) is or becomes convertible into or exchangeable (unless at
the sole option of the issuer thereof) for (i) debt securities or (ii) any Capital Stock that would constitute Disqualified Capital Stock, in each case at any time on or prior to 91 days following the Latest Maturity Date at the time such
Capital Stock is issued, (c) contains any mandatory repurchase obligation or any other repurchase obligation at the option of the holder thereof (other than for Qualified Capital Stock), in whole or in part, which may come into effect prior to
91 days following the Latest Maturity Date at the time such Capital Stock is issued (it being understood that if any such repurchase obligation is in part, only such part coming into effect prior to 91 days following the Latest Maturity Date shall
constitute Disqualified Capital Stock) or (d) provides for the scheduled payments of dividends in Cash on or prior to 91 days following the Latest Maturity Date at the time such Capital Stock is issued; provided that any Capital Stock
that would not constitute Disqualified Capital Stock but for provisions thereof giving holders thereof (or the holders of any security into or for which such Capital Stock is convertible, exchangeable or exercisable) the right to require the issuer
thereof to redeem such Capital Stock upon the occurrence of any change of control or any Disposition occurring prior to 91 days following the Latest Maturity Date at the time such Capital Stock is issued shall not constitute Disqualified Capital
Stock if such Capital Stock provides that the issuer thereof will not redeem any such Capital Stock pursuant to such provisions prior to the Termination Date. 

Notwithstanding the preceding sentence, (A) if such Capital Stock is issued pursuant to any plan for the benefit of directors, officers,
employees, members of management, managers or consultants or by any such plan to such directors, officers, employees, members of management, managers or consultants, in each case in the ordinary course of business of the Administrative Borrower or
any Restricted Subsidiary, such Capital Stock shall not constitute Disqualified Capital Stock solely because it may be required to be repurchased by the issuer thereof in order to satisfy applicable statutory or regulatory obligations, and
(B) no Capital Stock held by any future, present or former employee, director, officer, manager, member of management or consultant (or their respective Affiliates or Immediate Family Members) of the Administrative Borrower (or any Parent
Company or any subsidiary) shall be considered Disqualified Capital Stock because such stock is redeemable or subject to repurchase pursuant to any management equity subscription agreement, stock option, stock appreciation right or other stock award
agreement, stock ownership plan, put agreement, stockholder agreement or similar agreement that may be in effect from time to time. 

“Disqualified Institution” means: 

(a) (i) any Person identified in writing to the Arrangers on or prior to May 10, 2017the Amendment No. 2 Closing Date, (ii) any Person identified by
INC Holdingsthe Administrative Borrower or
Double Eagle Parent in writing and, by email to JPMDQ_Contact@jpmorgan.com, and reasonably acceptable to CS Securities and ING after May 10, 2017, and prior to thethe Administrative Agent after the Amendment No. 2 Closing Date (the Persons described in clauses (a)(i) through (a)(ii)
above, the “Identified Disqualified Lenders”) and (iii) any Affiliate of any Identified Disqualified Lender that is identified in writing, by email to
JPMDQ_Contact@jpmorgan.com, to the Administrative Agent as such, 

(b) any Affiliate of any Arranger (or any director (or equivalent manager), officer or employee of any Arranger or any
Affiliate thereof) that is engaged as a principal primarily in private equity or venture capital, 
 (c) (i) any Person
that is or becomes a Company Competitor and is (A) identified in writing to the Arrangers on or prior to May 10, 2017the Amendment No. 2 Closing Date, (B) identified by INC
Holdingsthe Administrative Borrower or Double Eagle Parent in writing to CS Securities and ING after May 10, 2017, and prior to theJPMorgan after the Amendment No. 2
Closing Date and (C) identified in writing to the Administrative Agent on or after the Closing Date, and (ii) 

  
 31 

 Restricted Subsidiary or any ERISA Affiliate as described in Section 4062(e) of ERISA, in each case,
resulting in liability pursuant to Section 4063 of ERISA; (c) a complete or partial withdrawal by the Administrative Borrower or any Restricted Subsidiary or any ERISA Affiliate from a Multiemployer Plan resulting in the imposition of
Withdrawal Liability on the Administrative Borrower or any Restricted Subsidiary, notification of the Administrative Borrower or any Restricted Subsidiary or any ERISA Affiliate concerning the imposition of Withdrawal Liability or notification that
a Multiemployer Plan is “insolvent” within the meaning of Section 4245 of ERISA or is in “reorganization” within the meaning of Section 4241 of ERISA; (d) the filing of a notice of intent to terminate a Pension
Plan under Section 4041(c) of ERISA, the treatment of a Pension Plan amendment as a termination under Section 4041(c) of ERISA, the commencement of proceedings by the PBGC to terminate a Pension Plan or the receipt by the Administrative
Borrower or any Restricted Subsidiary or any ERISA Affiliate of notice of the treatment of a Multiemployer Plan amendment as a termination under Section 4041A of ERISA or of notice of the commencement of proceedings by the PBGC to terminate a
Multiemployer Plan; (e) the occurrence of an event or condition which constitutes grounds under Section 4042 of ERISA for the termination of, or the appointment of a trustee to administer, any Pension Plan or Multiemployer Plan;
(f) the imposition of any liability under Title IV of ERISA, other than for PBGC premiums due but not delinquent under Section 4007 of ERISA, upon the Administrative Borrower or any Restricted Subsidiary or ERISA Affiliates, with respect
to the termination of any Pension Plan; or (g) the conditions for imposition of a Lien under Section 303(k) of ERISA have been met with respect to any Pension Plan. 

“EU Bail-In Legislation Schedule” means the EU Bail-In Legislation Schedule published by the Loan Market Association (or any
successor person), as in effect from time to time. 
 “Euro” or “€” means the single currency of the
European Union as constituted by the Treaty on European Union and as referred to in the EMU Legislation. 
 “Eurocurrency
Rate” means: 
 (a) with respect to any Interest Period applicable to an Adjusted Eurocurrency Rate Loan (other than
a Eurocurrency Rate Loan denominated in Canadian Dollars or a Eurocurrency Rate Loan denominated in Singaporean Dollars), (i) the
rate of interest in the applicable currency appearing on Reuters Screen LIBOR01 Page (or on any successor or substitute page of such service, or any successor to such service as determined by Administrative Agent) as the London interbank offered
rate for deposits in Dollars or such Alternate Currency for a term comparable to such Interest Period, at approximately 11:00 a.m. (London time) on the date which is two Business Days prior to the commencement of such Interest Period (but if more
than one rate is specified on such page, the rate will be an arithmetic average of all such rates) or (ii) if the rate described in clause (i) above does not appear on such page or service or such page or service is not available,
the rate per annum equal to the rate reasonably determined by the Administrative Agent to be the offered rate on such other page or service that displays an average British Bankers Association Interest Settlement Rate for deposits in Dollars offered
in the London interbank market (for delivery on the first day of such Interest Period) with a term equivalent to such Interest Period, determined as of approximately 11:00 a.m. (London time) two Business Days prior to the first day of such Interest
Period; and 
 (b) with respect to any Eurocurrency Rate Loan denominated in Canadian Dollars, the rate of interest
equal to the Canadian Dollar bankers’ acceptance rate, or comparable or successor rate approved by the Administrative Agent, determined by it at or about 10:00 a.m. (Toronto time) on the applicable day (or the preceding Business Day, if the
applicable day is not a Business Day) for a term comparable to the Revolving Loan, as published on the CDOR or other applicable Reuters screen page (or other commercially available source designated by the Administrative Agent from time to time).

  
 34 

 (c) with
respect to any Eurocurrency Rate Loan denominated in Singaporean Dollars, the rate of interest equal to
the Association of Banks in Singapore, or comparable or successor rate approved by the Administrative Agent, determined by it at or about 12:00 p.m. (London time) two Business Days
prior to the commencement of the applicable Interest Period (or the preceding Business Day, if the applicable day is not a Business Day) for a term comparable to the Revolving Loan, as published on the ABSFIX01 or other applicable Reuters screen
page (or other commercially available source designated by the Administrative Agent from time to time). 
 In no event shall the Eurocurrency Rate be less than zero. 

“Event of Default” has the meaning assigned to such term in Article 7. 

“Excess Cash Flow” means, for any Excess Cash Flow Period, any amount (if positive) equal to (without duplication): 

(a) Consolidated Adjusted EBITDA for such Excess Cash Flow Period (without giving effect to clauses (b) or
(e) of the definition thereof, the amounts added back in reliance on which shall be deducted in determining Excess Cash Flow); plus 

(b) any extraordinary, unusual or non-recurring cash gain during such Excess Cash Flow Period (whether or not accrued in such
Excess Cash Flow Period), to the extent not otherwise included in Consolidated Adjusted EBITDA; plus 
 (c) net
foreign currency translation gains received in cash related to currency remeasurements of Indebtedness (including any net gain resulting from any Hedge Agreement for currency exchange risk resulting from any intercompany Indebtedness, any foreign
currency translation or transaction or any other currency-related risk), to the extent not otherwise included in calculating Consolidated Adjusted EBITDA; plus 

(d) the decrease, if any, in Consolidated Working Capital from the first day to the last day of such Excess Cash Flow Period,
excluding any such decrease in Consolidated Working Capital arising from (i) the acquisition or Disposition of any Person by the Administrative Borrower or any Restricted Subsidiary, (ii) the reclassification during such period of current
assets to long term assets and current liabilities to long term liabilities, (iii) the application of purchase and/or recapitalization accounting and/or (iv) the effect of any fluctuation in the amount of accrued and contingent obligations
under any Hedge Agreement; minus 
 (e) the amount, if any, which, in the determination of Consolidated Adjusted
EBITDA for such Excess Cash Flow Period, has been included in respect of income or gain from any Disposition outside of the ordinary course of business (including Dispositions constituting covered losses or taking of assets referred to in the
definition of “Net Insurance/Condemnation Proceeds”) of the Administrative Borrower and/or any Restricted Subsidiary; minus 

(f) cash payments actually made in respect of the following (without duplication): 

(i) any Investment permitted by Section 6.06 (other than Investments (i) in Cash or Cash Equivalents or
(ii) in any Loan Party and/or any Restricted Payment permitted by Section 6.04(a)) and actually made in cash during such Excess Cash Flow Period or, at the option of the Administrative Borrower, made prior to the date the
Administrative Borrower is required to make a payment of Excess Cash Flow in respect of such Excess Cash Flow Period, (A) except to the extent the relevant Investment and/or Restricted Payment is financed with long term Indebtedness (other than
revolving Indebtedness) and (B) without 

  
 35 

 extent such reserves or amounts are added back to, or not deducted from, Consolidated Net
Income.; minus 

(q) cash losses, charges and other adjustments resulting from the
application of FASB ASC Update No. 2014-09 (Revenue from Contracts with Customers (Topic 606))
effective January 1, 2018. 
 “Excess Cash Flow Period”
means each Fiscal Year of the Administrative Borrower, commencing with the Fiscal Year of the Administrative Borrower ending on December 31, 2018. 

“Exchange Act” means the Securities Exchange Act of 1934 and the rules and regulations of the SEC promulgated thereunder.

 “Excluded Assets” means each of the following: 

(a) any asset the grant or perfection of a security interest in which would (i) be prohibited by any enforceable
anti-assignment provision set forth in any contract that is permitted or otherwise not prohibited by the terms of this Agreement and is binding on such asset at the time of its acquisition and not incurred in contemplation thereof (other than assets
subject to Capital Leases and purchase money financings), (ii) violate the terms of any contract relating to such asset that is permitted or otherwise not prohibited by the terms of this Agreement and is binding on such asset at the time of its
acquisition and not incurred in contemplation thereof (other than in the case of Capital Leases and purchase money financings) (in the case of clause (i) above and this clause (ii), after giving effect to any applicable
anti-assignment provision of the UCC or other applicable Requirements of Law) or (iii) trigger termination of any contract relating to such asset that is permitted or otherwise not prohibited by the terms of this Agreement pursuant to any
“change of control” or similar provision (to the extent such contract is binding on such asset at the time of its acquisition and not incurred in contemplation thereof); it being understood that the term “Excluded Asset” shall
not include proceeds or receivables arising out of any contract described in this clause (a) to the extent that the assignment of such proceeds or receivables is expressly deemed to be effective under the UCC or any other applicable
Requirement of Law notwithstanding the relevant prohibition, violation or termination right, 
 (b) the Capital Stock of any
(i) Captive Insurance Subsidiary, (ii) Unrestricted Subsidiary, (iii) not-for-profit subsidiary and/or (iv) special purpose entity used for any permitted securitization facility (including any Permitted Receivables Facility),

 (c) any intent-to-use Trademark application prior to the filing and acceptance of a “Statement of Use”,
“Declaration of Use”, “Amendment to Allege Use” or similar notice and/or filing with respect thereto, only to the extent, if any, that, and solely during the period if any, in which, the grant of a security interest therein may
impair the validity or enforceability, or result in the voiding, of such intent-to-use Trademark application or any registration issuing therefrom under applicable Requirements of Law, 

(d) any asset, the grant or perfection of a security interest in which would (i) require any governmental or regulatory
consent, approval, license or authorization that has not been obtained, (ii) be prohibited by applicable Requirements of Law (including, without limitation, rules and regulations of any governmental authority or agency), except, in each case of
clause (i) above and this clause (ii), to the extent such requirement or prohibition would be rendered ineffective under the UCC or any other applicable Requirement of Law notwithstanding such requirement or prohibition; it being
understood that the term “Excluded Asset” shall not include proceeds or receivables arising out of any asset described in clause (d)(i) or clause (d)(ii) to the extent that the assignment of such proceeds or receivables is
expressly deemed to be effective under the UCC or any other applicable Requirement of 

  
 38 

 Guaranty of such Loan Guarantor or the grant of such security interest becomes effective with respect to
such Swap Obligation or (b) in the case of any Swap Obligation that is subject to a clearing requirement pursuant to section 2(h) of the Commodity Exchange Act, because such Loan Guarantor is a “financial entity,” as defined in
section 2(h)(7)(C) of the Commodity Exchange Act, at the time the guarantee provided by (or grant of such security interest by, as applicable) such Loan Guarantor becomes or would become effective with respect to such Swap Obligation. If any Swap
Obligation arises under a master agreement governing more than one swap, such exclusion shall apply only to the portion of such Swap Obligation that is attributable to swaps for which such Loan Guaranty or security interest is or becomes illegal.

 “Excluded Taxes” means, with respect to the Administrative Agent, any Lender or Issuing Bank or any other recipient (in
each case, a “Recipient”) of any payment to be made by or on account of any obligation of any Loan Party under any Loan Document, (a) Taxes imposed on (or measured by) its net or overall gross income or franchise Taxes
(i) imposed as a result of such Recipient being organized or having its principal office located in or, in the case of any Lender, having its applicable lending office located in, the taxing jurisdiction or (ii) that are Other Connection
Taxes, (b) any branch profits Taxes imposed under Section 884(a) of the Code or any similar Tax imposed by any jurisdiction described in clause (a), (c) any U.S. federal withholding tax that is imposed on amounts payable to the
relevant Recipient pursuant to a Requirement of Law in effect at the time the relevant Recipient becomes a party to this Agreement (or designates a new lending office), except (i) in the case of a Recipient that became a recipient pursuant to
an assignment under Section 2.19 or a Recipient that designates a new lending office under Section 2.19 and (ii) to the extent that the relevant Recipient (or its assignor, if any) was entitled, immediately prior to the
designation of a new lending office (or assignment), to receive additional amounts from any Loan Party with respect to such withholding tax pursuant to Section 2.17, (d) any tax imposed as a result of a failure by such Recipient to
comply with Section 2.17(f) and (e) any U.S. federal withholding tax under FATCA. 

“Existing Bank of America Amendment No. 2 Closing Date Letters of
Credit” means any letter of credit previously issued that is listed on Schedule 1.01(e)(ii) hereto. 

“Existing Bank of America Closing Date Letters of Credit” means any letter of credit previously issued that (a) will remain outstanding on and after the Closing Date and (b) is listed on Schedule 1.01(e)(i) hereto. 
 “Existing Credit Suisse Amendment No. 2 Closing Date Letters of Credit” means any letter of credit previously issued that is listed on Schedule 1.01(e)(iii) hereto. 
 “Existing ING Amendment
No. 2 Closing Date Letters of Credit” means any letter of credit previously issued that is listed on Schedule 1.01(e)(iv) hereto. 

“Existing Letters of Credit” means, collectively, the Existing Bank of
America Closing Date Letters of Credit, the Existing Bank of America Amendment No. 2 Closing Date Letters of Credit, the Existing Credit Suisse Amendment No. 2 Closing Date Letters of Credit and the Existing ING Amendment No. 2
Closing Date Letters of Credit, listed on Schedule 1.01(e) hereto. 

“Expected Cost Savings” has the meaning assigned to such term in the definition of “Consolidated Adjusted EBITDA”.

 “Extended Revolving Credit Commitment” has the meaning assigned to such term in Section 2.23(a)(i). 

“Extended Revolving Facility” has the meaning assigned to such term in Section 2.23(a)(i). 

“Extended Revolving Loans” has the meaning assigned to such term in Section 2.23(a)(i). 

  
 41 

 “Extended Term Loans” has the meaning assigned to such term in
Section 2.23(a)(ii). 
 “Extension” has the meaning assigned to such term in Section 2.23(a). 

“Extension Amendment” means an amendment to this Agreement that is reasonably satisfactory to the Administrative Agent (for
purposes of giving effect to Section 2.23) and the Administrative Borrower executed by each of (a) the Administrative Borrower and the Subsidiary Guarantors, (b) the Administrative Agent and (c) each Lender that has
accepted the applicable Extension Offer pursuant hereto and in accordance with Section 2.23. 
 “Extension
Offer” has the meaning assigned to such term in Section 2.23(a). 
 “Facility” means any real property
(including all buildings, fixtures or other improvements located thereon) now, hereafter or, except with respect to Articles 5 and 6, hereof owned, leased, operated or used by the Administrative Borrower or any of its Restricted
Subsidiaries or any of their respective predecessors or Affiliates. 
 “FATCA” means Sections 1471 through 1474 of the
Code, as of the date of this Agreement (or any amended or successor version that is substantively comparable and not materially more onerous to comply with), any current or future regulations or official interpretations thereof, any agreements
entered into pursuant to current Section 1471(b)(1) of the Code (or any amended or successor version described above) and any intergovernmental agreements implementing any of the
foregoing and relatedfiscal or regulatory legislation
or official administrative, rules or practices
with respect theretoadopted pursuant to any intergovernmental agreement, treaty or convention among
Governmental Authorities and implementing such Sections of the Code. 

“FCPA” has the meaning assigned to such term in Section 3.17(c). 

“Federal Funds Effective Rate” means, for any day, the rate calculated by the Federal Reserve Bank of New York based on such
day’s federal funds transactions by depositary institutions (as determined in such manner as the Federal Reserve Bank of New York sets forth on its public website from time to time) and published on the next succeeding Business Day by the
Federal Reserve Bank of New York as the federal funds effective rate. 
 “Fee LettersLetter” means that certain fee lettersletter dated Juneas of February 14, 2017, by and2019 among, inter alios, the Administrative Borrower, the applicable Arrangers and the Administrative
Agent. 
 “Financial Covenant Standstill” has the meaning assigned to such term in Section 7.01(c). 

“First Lien Intercreditor Agreement” means an intercreditor agreement substantially in the form of Exhibit K-1 hereto, with
any changes thereto as the Administrative Borrower and the Administrative Agent may agree in their respective reasonable discretion. 

“First Lien Leverage Ratio” means the ratio, as of any date of determination, of (a) Consolidated First Lien Debt as of
the last day of the Test Period then most recently ended to (b) Consolidated Adjusted EBITDA for the Test Period then most recently ended, in each case of the Administrative Borrower and its Restricted Subsidiaries on a consolidated basis. 

“First Priority” means, with respect to any Lien purported to be created on any Collateral pursuant to any Collateral
Document, that, subject to any applicable Intercreditor Agreement, such Lien is senior in priority to any other Lien to which such Collateral is subject, other than any Permitted Lien. 

  
 42 

 “Fiscal Quarter” means a fiscal quarter of any Fiscal Year. 

“Fiscal Year” means the fiscal year of the Administrative Borrower ending December 31 of each calendar year. 

“Fixed Amount” has the meaning assigned to such term in Section 1.10(d). 

“Flood Hazard Property” means any parcel of any Material Real Estate Asset located in the U.S. that is subject to a Mortgage
that has Improvements (as defined in the Flood Insurance Laws) in an area designated by the Federal Emergency Management Agency as having special flood or mud slide hazards. 

“Flood Insurance Laws” means, collectively, (a) National Flood Insurance Reform Act of 1994 (which comprehensively
revised the National Flood Insurance Act of 1968 and the Flood Disaster Protection Act of 1973), (b) the Flood Insurance Reform Act of 2004 and (c) the Biggert-Waters Flood Insurance Reform Act of 2012. 

“Florida Loan Party” means South Florida
Kinetics, Inc., a Florida corporation. 

“Foreign Lender” means any Lender or Issuing Bank that is not a “United States person” within the meaning of
Section 7701(a)(30) of the Code. 
 “Foreign Subsidiary” means any Restricted Subsidiary that is not a Domestic
Subsidiary. 
 “GAAP” means generally accepted accounting principles in the U.S. in effect and applicable to the accounting
period in respect of which reference to GAAP is made. 
 “Governmental Authority” means any federal, state, municipal,
national or other government, governmental department, commission, board, bureau, court, agency or instrumentality or political subdivision thereof or any entity or officer exercising executive, legislative, judicial, regulatory or administrative
functions of or pertaining to any government or any court, in each case whether associated with the US, a foreign government or any political subdivision thereof. 

“Governmental Authorization” means any permit, license, authorization, approval, plan, directive, consent order or consent
decree of or from any Governmental Authority. 
 “Granting Lender” has the meaning assigned to such term in
Section 9.05(f). 
 “Guarantee” of or by any Person (the “Guarantor”) means any obligation,
contingent or otherwise, of the Guarantor guaranteeing or having the economic effect of guaranteeing any Indebtedness or other monetary obligation of any other Person (the “Primary Obligor”) in any manner and including any
obligation of the Guarantor (a) to purchase or pay (or advance or supply funds for the purchase or payment of) such Indebtedness or other monetary obligation or to purchase (or to advance or supply funds for the purchase of) any security for
the payment thereof, (b) to purchase or lease property, securities or services for the purpose of assuring the owner of such Indebtedness or other monetary obligation of the payment thereof, (c) to maintain working capital, equity capital
or any other financial statement condition or liquidity of the Primary Obligor so as to enable the Primary Obligor to pay such Indebtedness or other monetary obligation, (d) as an account party in respect of any letter of credit or letter of
guaranty issued to support such Indebtedness or monetary obligation, (e) entered into for the purpose of assuring in any other manner the obligee in respect of such Indebtedness or other monetary obligation of the payment or performance thereof
or to protect such obligee against loss in respect thereof (in whole or in part) or (f) secured by any Lien on any assets of such Guarantor securing any Indebtedness or other monetary obligation of any other Person, whether or not such
Indebtedness or monetary other obligation is assumed by such Guarantor (or any right, contingent or otherwise, of any holder of such Indebtedness or other monetary obligation to obtain any such Lien); provided that the term 

  
 43 

 “INC Contribution” has the meaning assigned to such term in the recitals
hereto. 
 “INC Holdings” has the meaning assigned to such term in the preamble to this Agreement. 

“INC Refinancing” means the termination of the revolving commitments and refinancing of the outstanding Indebtedness under
the Credit Agreement, dated as of May 14, 2015, by and among, inter alios, INC Holdings, as holdings, INC Research, as borrower, the lenders from time to time party thereto and Wells Fargo Bank, National Association, as administrative
agent and collateral agent. 
 “INC Research” means Syneos
Health, LLC (f/k/a INC Research, LLC), a Delaware limited liability company. 

“Incremental Amount” means (a) the greater of (i) $725,000,000 and (ii) 100% of Consolidated Adjusted EBITDA
as of the last day of the most recently ended Test Period minus (b) the aggregate outstanding principal amount of all Incremental Facilities and/or Incremental Equivalent Debt incurred or issued in reliance on the Incremental Amount.; provided that, the Incremental Term A Loans (including, for the avoidance of doubt, any Delayed Draw
Term A Loans) and Incremental Revolving Credit Commitments (each as defined in Amendment No. 2) shall not reduce the amount available to the Borrowers pursuant to clause (a)(i) above (such that, for the avoidance of doubt, $725,000,000 remains
available for use by the Borrowers under clause (a)(i) of this definition after giving effect to Amendment No. 2). 

“Incremental Cap” means (without duplication): 

(a) the Incremental Amount, plus 

(b) in the case of any Incremental Facility incurred using the Incremental Amount that effectively extends the Maturity Date
with respect to any Class of Loans and/or Commitments hereunder, an amount equal to the portion of the relevant Class of Loans or Commitments that will be replaced by such Incremental Facility, plus 

(c) in the case of any Incremental Facility incurred using the Incremental Amount that effectively replaces any Revolving
Credit Commitment terminated in accordance with Section 2.19 hereof, an amount equal to the relevant terminated Revolving Credit Commitment, plus 

(d) (i) the amount of any optional prepayment of any Term Loan in accordance with Section 2.11(a) and/or the
amount of any permanent reduction of any Revolving Credit Commitment and/or the amount of any permanent prepayment of any Incremental Equivalent Debt, in each case that is secured on a pari passu basis with the Initial Term Loans,
(ii) the amount of any optional prepayment, redemption or repurchase of any Replacement Term Loan or Loans under any Replacement Revolving Facility (to the extent accompanied by a permanent reduction in commitments) or any borrowing or issuance
of Replacement Debt, in each case that is secured on a pari passu basis with the Initial Term Loans, previously applied to the permanent prepayment of any Loan hereunder, so long as no Incremental Facility was previously incurred in reliance
on clause (d)(i) above as a result of such prepayment and (iii) the amount paid in Cash in respect of any reduction in the outstanding amount of any Term Loan that is secured on a pari passu basis with the Initial Term Loans
resulting from any assignment of such Term Loan to (and/or assignment and/or purchase of such Term Loan by) the Administrative Borrower and/or any Restricted Subsidiary, for each of clauses (i), (ii) and (iii) so long
as the relevant prepayment, redemption, repurchase, assignment and/or purchase was not funded with the proceeds of any long-term Indebtedness (other than revolving Indebtedness), plus 

(e) an unlimited amount so long as, in the case of this clause (e), after giving effect to the relevant Incremental
Facility, (i) if such Incremental Facility is secured by a lien on the Collateral 

  
 45 

 Leverage Ratio, the Interest Coverage Ratio or any other financial ratio under this Agreement, (ii) the
amount of Indebtedness of any Person for purposes of clause (e) shall be deemed to be equal to the lesser of (A) the aggregate unpaid amount of such Indebtedness and (B) the fair market value of the property encumbered thereby
as determined by such Person in good faith and (iii) the term “Indebtedness” shall exclude (A) any obligation under or in respect of any Permitted Receivables Facility, (B) any obligations incurred under ERISA,
(C) accrued expenses and trade accounts payable in the ordinary course of business (including on an inter-company basis) and (D) liabilities associated with customer prepayments and deposits. 

For all purposes hereof, the Indebtedness of any Person shall include the Indebtedness of any third person (including any partnership in which
such Person is a general partner and any unincorporated joint venture in which such Person is a joint venturer) to the extent such Person would be liable therefor under applicable Requirements of Law or any agreement or instrument by virtue of such
Person’s ownership interest in such Person, (A) except to the extent the terms of such Indebtedness provided that such Person is not liable therefor and (B) only to the extent the relevant Indebtedness is of the type that would be
included in the calculation of Consolidated Total Debt; provided that notwithstanding anything herein to the contrary, the term “Indebtedness” shall not include, and shall be calculated without giving effect to, (x) the effects
of Accounting Standards Codification Topic 815 and related interpretations to the extent such effects would otherwise increase or decrease an amount of Indebtedness for any purpose hereunder as a result of accounting for any embedded derivatives
created by the terms of such Indebtedness (it being understood that any such amounts that would have constituted Indebtedness hereunder but for the application of this proviso shall not be deemed an incurrence of Indebtedness hereunder) and
(y) the effects of Statement of Financial Accounting Standards No. 133 and related interpretations to the extent such effects would otherwise increase or decrease an amount of Indebtedness for any purpose hereunder as a result of
accounting for any embedded derivative created by the terms of such Indebtedness (it being understood that any such amounts that would have constituted Indebtedness hereunder but for the application of this proviso shall not be deemed to be an
incurrence of Indebtedness hereunder). 
 “Indemnified Taxes” means (a) all Taxes, other than Excluded Taxes or Other
Taxes, imposed on or with respect to any payment made by or on account of any obligation of any Loan Party under any Loan Document and (b) to the extent not otherwise described in clause (a), Other Taxes. 

“Indemnitee” has the meaning assigned to such term in Section 9.03(b). 

“Information Memorandum” means the Confidential Information Memorandum dated June 2017 relating to the Administrative
Borrower and its subsidiaries and the Transactions. 
 “ING” has the meaning assigned to such term in the preamble to this
Agreement. 
 “Initial Lenders” means the Arrangers and the affiliates of the Arrangers who are party to this Agreement as
Lenders on the Closing Date. 
 “Initial Revolving Credit Commitment” means, with respect to each Lender, the commitment of
such Lender to make Initial Revolving Loans (and acquire participations in Letters of Credit) hereunder as set forth on the Commitment Scheduleopposite such Lender’s name on Schedules 1-B and 2-C to Amendment No. 2), or in the Assignment Agreement pursuant to which such
Lender assumed its Initial Revolving Credit Commitment, as applicable, as the same may be (a) reduced from time to time pursuant to Section 2.09 or 2.19, (b) reduced or increased from time to time pursuant to assignments
by or to such Lender pursuant to Section 9.05 or (c) increased pursuant to Section 2.22. The aggregate amount of the Initial Revolving Credit Commitments as of the Amendment No. 2 Closing Date is $500,000,000600,000,000. 

  
 50 

 “Initial Revolving Credit Exposure” means, with respect to any Lender at
any time, the aggregate Outstanding Amount at such time of all Initial Revolving Loans of such Lender, plus the aggregate amount at such time of such Lender’s LC Exposure, in each case, attributable to its Initial Revolving Credit
Commitment. 
 “Initial Revolving Credit Maturity Date” means the date that is five years after the Amendment No. 2 Closing Date. 

“Initial Revolving Facility” means the Initial Revolving Credit Commitments and the Initial Revolving Loans and other
extensions of credit thereunder. 
 “Initial Revolving Lender” means any Lender with an Initial Revolving Credit Commitment
or any Initial Revolving Credit Exposure. 
 “Initial Revolving Loan” means any revolving loan made by the Initial
Revolving Lenders to the Borrowers pursuant to Section 2.01(a)(iii). 
 “Initial Term A Lender” means any
Lender with an Initial Term A Loan Commitment or an outstanding Initial Term A Loan. 
 “Initial Term A Loan Commitment”
means, with respect to each Term Lender, the commitment of such Term Lender to make Initial Term A Loans hereunder in an aggregate amount not to exceed the amount set forth opposite such Term Lender’s name on the Commitment ScheduleSchedules 1-A and 2-A to Amendment No. 2, as the same may be (a) reduced from time to time pursuant to Section 2.09, (b) reduced or increased from time to time pursuant to assignments by or to such Term A Lender pursuant to
Section 9.05 or (c) increased from time to time pursuant to Section 2.22. The aggregate amount of the Term Lenders’ Initial Term A Loan Commitments on the
Amendment No. 2 Closing Date is
$1,000,000,0001,150,000,000. 

“Initial Term A Loans” means the term loans made by the Initial Term A Lenders to the Borrowers pursuant to
Section 2.01(a)(i) and the Replacement Term A Loans (as defined in Amendment
No. 1).. 
 “Initial Term A Loan Maturity Date” means the date that is five years after
the Amendment No. 2 Closing Date. 

“Initial Term B Lender” means any Lender with an Initial Term B Loan Commitment or an outstanding Initial Term B Loan. 

“Initial Term B Loan Commitment” means, with respect to each Term Lender, the commitment of such Term Lender to make Initial
Term B Loans hereunder in an aggregate amount not to exceed the amount set forth opposite such Term Lender’s name on the Commitment Schedule 1-B to Amendment No. 1, as the same may be (a) reduced from time to time
pursuant to Section 2.09, (b) reduced or increased from time to time pursuant to assignments by or to such Term Lender pursuant to Section 9.05 or (c) increased from time to time pursuant to
Section 2.22. The aggregate amount of the Term Lenders’ Initial Term B Loan Commitments on the Closing Date is $1,600,000,000. 

“Initial Term B Loans” means the term loans made by the Initial Term B Lenders to the Borrowers pursuant to
Section 2.01(a)(ii) and the Replacement Term B Loans (as defined in Amendment No. 1). 
 “Initial Term B Loan
Maturity Date” means the date that is seven years after the Closing Date. 

  
 51 

 month, in which case such Interest Period shall end on the next preceding Business Day and (ii) any
Interest Period that commences on the last Business Day of a calendar month (or on a day for which there is no numerically corresponding day in the last calendar month of such Interest Period) shall end on the last Business Day of the last calendar
month of such Interest Period. For purposes hereof, the date of a Borrowing initially shall be the date on which such Borrowing is made and thereafter shall be the effective date of the most recent conversion or continuation of such Borrowing. 

“inVentiv Group Holdings” means inVentiv Group Holdings, Inc., a Delaware corporation. 

“inVentiv Group Holdings Share Purchase” has the meaning assigned to such term in the recitals hereto. 

“inVentiv Refinancing” means (a) the refinancing of the Indebtedness outstanding under the First Lien Term Loan
Agreement, dated as of November 9, 2016, by and among, inter alios, inVentiv Group Holdings, as administrative borrower, the lenders from time to time party thereto and Goldman Sachs Bank USA, as administrative agent and collateral agent
and (b) the termination of the commitments and refinancing of the Indebtedness outstanding under the ABL Credit Agreement, dated as of November 9, 2016, by and among, inter alios, inVentiv Group Holdings, as a borrower, the lenders
from time to time party thereto and Bank of America, N.A., as administrative agent and collateral agent (other than with respect to the Existing Bank of America Closing Date Letters of Credit). 
 “Investment” means (a) any purchase or other
acquisition by the Administrative Borrower or any of its Restricted Subsidiaries of any of the Securities of any other Person (other than any Loan Party), (b) the acquisition by purchase or otherwise (other than any purchase or other
acquisition of inventory, materials, supplies and/or equipment in the ordinary course of business) of all or a substantial portion of the business, property or fixed assets of any other Person or any division or line of business or other business
unit of any other Person and (c) any loan, advance (other than any advance to any current or former employee, officer, director, member of management, manager, consultant or independent contractor of the Administrative Borrower, any Restricted
Subsidiary, or any Parent Company for moving, entertainment and travel expenses, drawing accounts and similar expenditures in the ordinary course of business) or capital contribution by the Administrative Borrower or any of its Restricted
Subsidiaries to any other Person. Subject to Section 5.10, the amount of any Investment shall be the original cost of such Investment, plus the cost of any addition thereto that otherwise constitutes an Investment, without any
adjustments for increases or decreases in value, or write- ups, write-downs or write-offs with respect thereto, but giving effect to any repayments of principal in the case of any Investment in the form of a loan and any return of capital or return
on Investment in the case of any equity Investment (whether as a distribution, dividend, redemption or sale but not in excess of the amount of the relevant initial Investment). 

“Investors” means (a) the Sponsors and (b) the Management Investors. 

“IP Rights” has the meaning assigned to such term in Section 3.05(c). 

“IRS” means the United States Internal Revenue Service. 

“Issuing Bank” means, as the context may require,
(a) Credit Suisse, (b) ING, (cJPMorgan Chase Bank, N.A., (b) Wells Fargo Bank, N.A.,
(c) PNC Bank, N.A., (d) Bank of America, N.A., (e) ING Capital LLC, (f) with respect to the Existing Bank of
America Closing Date Letters of Credit and the Existing Bank of America Amendment No. 2 Closing Date Letters of Credit, Bank of America, N.A., (g) with respect to the Existing Credit Suisse Amendment No. 2 Closing Date Letters of Credit, Credit Suisse, (h) with respect to the Existing ING Amendment No. 2 Closing
Date Letters of Credit, ING Capital LLC and (di) any other
Revolving Lender that is appointed as an Issuing Bank in accordance with Section 2.05(i) hereof. Each Issuing Bank may, in its discretion, arrange for one or more Letters of Credit to be issued by any branch or Affiliate of such Issuing
Bank, in which case the term “Issuing Bank” shall include any such branch or Affiliate with respect to Letters of Credit issued by such branch or Affiliate. 

  
 53 

 “Joinder Agreement” means a Joinder Agreement substantially in the form of
Exhibit F or such other form that is reasonably satisfactory to the Administrative Agent and the Administrative Borrower. 

“Judgment Currency” has the meaning assigned to such term in Section 9.25. 

“Junior Indebtedness” means any Indebtedness of the types described in clauses (a) and (c) of the
definition of “Indebtedness” (other than Indebtedness among the Administrative Borrower and/or any Restricted Subsidiary) of any Loan Party that is expressly subordinated in right of payment to the Obligations. 

“Junior Lien Indebtedness” means any Indebtedness of the types described in clauses (a) and (c) of
the definition of “Indebtedness” that is secured by a security interest on the Collateral of any Loan Party (other than Indebtedness among the Administrative Borrower and/or any Restricted Subsidiary) that is expressly junior or
subordinated to the Lien securing the Credit Facilities. 
 “Latest Maturity Date” means, as of any date of determination,
the latest maturity or expiration date applicable to any Loan or commitment hereunder at such time, including the latest maturity or expiration date of any Term Loan, Term Commitment, Revolving Loan or Revolving Credit Commitment. 

“Latest Revolving Credit Maturity Date” means, as of any date of determination, the latest maturity or expiration date
applicable to any Revolving Loan or Revolving Credit Commitment hereunder at such time. 
 “Latest Term Loan Maturity Date”
means, as of any date of determination, the latest maturity or expiration date applicable to any Term Loan hereunder at such time. 

“LC Collateral Account” has the meaning assigned to such term in Section 2.05(j). 

“LC Disbursement” means any payment or disbursement made by any Issuing Bank pursuant to any Letter of Credit. 

“LC Exposure” means, at any time, the sum of (a) the aggregate undrawn amount of all outstanding Letters of Credit at
such time and (b) the aggregate principal amount of all LC Disbursements that have not yet been reimbursed at such time. The LC Exposure of any Revolving Lender at any time shall equal its Applicable Percentage of the aggregate LC Exposure at
such time. 
 “Legal Reservations” means the application of relevant Debtor Relief Laws, general principles of equity
and/or principles of good faith and fair dealing. 
 “Lenders” means the Term Lenders, the Revolving Lenders and any other
Person that becomes a party hereto pursuant to an Assignment Agreement, other than any such Person that ceases to be a party hereto pursuant to an Assignment Agreement. 

“Letter of Credit” means any Standby Letter of Credit or Commercial Letter of Credit issued (or, in the case of any Existing Bank of America Closing Date Letter of Credit Letter of Credit, deemed to be issued) pursuant to this Agreement. 

“Letter of Credit Reimbursement Loan” has the meaning assigned to such term in Section 2.05(e). 

“Letter-of-Credit Right” has the meaning set forth in Article 9 of the UCC. 

  
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 “Letter of Credit Request” means a request by the Administrative Borrower
for a new Letter of Credit or an amendment to any existing Letter of Credit in accordance with Section 2.05 and substantially in the form of Exhibit N hereto or such other form that is reasonably satisfactory to the relevant
Issuing Bank and the Administrative Borrower. 
 “Letter of Credit Sublimit” means $150,000,000, subject to increase in
accordance with Section 2.22 hereof. 
 “Liberty Lane” means Liberty Lane IH LLC and its Affiliates. 

“Lien” means any mortgage, pledge, hypothecation, assignment, deposit arrangement, encumbrance, lien (statutory or other),
charge, or preference, priority or other security interest or preferential arrangement of any kind or nature whatsoever (including any conditional sale or other title retention agreement, any easement, right of way or other encumbrance on title to
real property, and any Capital Lease having substantially the same economic effect as any of the foregoing), in each case, in the nature of security; provided that in no event shall an operating lease in and of itself be deemed to constitute
a Lien. 
 “Limited Condition Acquisition” means any acquisition or similar Investment, including by way of merger, by the
Administrative Borrower or one or more of its Restricted Subsidiaries permitted pursuant to this Agreement whose consummation is not conditioned upon the availability of, or on obtaining, third party financing. 

“Loan Documents” means this Agreement, Amendment No. 1,
Amendment No. 2, any Promissory Note, the Loan Guaranty, the Collateral Documents, any Intercreditor Agreement to which any Loan
Party is a party, each Refinancing Amendment, each Incremental Facility Amendment, each Extension Amendment and any other document or instrument designated by the Administrative Borrower and the Administrative Agent as a “Loan Document.”
Any reference in this Agreement or any other Loan Document to any Loan Document shall include all appendices, exhibits or schedules thereto. 

“Loan Guarantor” means any Subsidiary Guarantor and, as to the Secured Obligations of all other Borrowers, each Borrower.

 “Loan Guaranty” means (a) the Guaranty Agreement, substantially in the form of Exhibit I, executed by each
Loan Party party thereto and the Administrative Agent for the benefit of the Secured Parties, as supplemented in accordance with the terms of Section 5.12 and (b) solely with respect to any Foreign Subsidiary designated as a
Subsidiary Guarantor pursuant to the penultimate sentence of the definition of “Subsidiary Guarantor”, any local law guaranty that may have been executed by such Foreign Subsidiary. 

“Loan Installment Date” means a Term A Loan Installment Date and/or a Term B Loan Installment Date, as applicable. 

“Loan Parties” means each Borrower and each Subsidiary Guarantor. 

“Loans” means any Initial Term Loan, any Delayed Draw Term
A Loan, any Additional Term Loan, any Revolving Loan or any Additional Revolving Loan. 

“London Banking Day” means any day on which dealings in Dollar or the relevant Alternate Currency, as applicable, deposits
are conducted by and between banks in the London interbank market. 
 “Management Investors” means the officers, directors,
managers, employees and members of management of the Administrative Borrower, any Parent Company and/or any subsidiary of the Administrative Borrower. 

  
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 “Margin Stock” has the meaning assigned to such term in Regulation U. 

“Material Acquisition” means any Permitted Acquisition or similar Investment (including any Investment in a Similar Business)
the aggregate consideration for which exceeds $225,000,000. 
 “Material Adverse Effect” means (a) on the Closing
Date, a Closing Date Material Adverse Effect and (b) after the Closing Date, a material adverse effect on (i) the business, assets, financial condition or results of operations, in each case, of the Administrative Borrower and its Restricted
Subsidiaries, taken as a whole, (ii) the rights and remedies (taken as a whole) of the Administrative Agent under the applicable Loan Documents or (iii) the ability of the Loan Parties (taken as a whole) to perform their payment
obligations under the applicable Loan Documents. 
 “Material Debt Instrument” means any physical instrument evidencing any
Indebtedness for borrowed money which is required to be pledged and delivered to the Administrative Agent (or its bailee) pursuant to the Security Agreement. 

“Material Real Estate Asset” means (a) on the Closing Date, each “fee-owned” Real Estate Asset having a fair
market value (as reasonably determined by the Administrative Borrower after taking into account any liabilities with respect thereto that impact such fair market value) in excess of $20,000,000, as listed on Schedule 1.01(c) and (b) any
“fee-owned” Real Estate Asset acquired by any Loan Party after the Closing Date having a fair market value (as reasonably determined by the Administrative Borrower after taking into account any liabilities with respect thereto that impact
such fair market value) in excess of $20,000,000 as of the date of acquisition thereof. 
 “Maturity Date” means
(a) with respect to the Initial Revolving Facility, the Initial Revolving Credit Maturity Date, (b) with respect to the Initial Term A Loans and the Delayed Draw Term A Loans, the Initial Term A Loan Maturity Date, (c) with respect to the Initial Term B Loans, the Initial Term B Loan Maturity Date, (d) with respect to any Replacement Term Loans or Replacement
Revolving Facility, the final maturity date for such Replacement Term Loans or Replacement Revolving Facility, as the case may be, as set forth in the applicable Refinancing Amendment, (e) with respect to any Incremental Facility, the final
maturity date set forth in the applicable Incremental Facility Amendment, and (f) with respect to any Extended Revolving Credit Commitment or Extended Term Loans, the final maturity date set forth in the applicable Extension Amendment.

 “Maximum Rate” has the meaning assigned to such term in Section 9.20. 

“Merger Agreement” means that certain Agreement and Plan of Merger, dated as of May 10, 2017, by and between Double
Eagle Parent and INC Holdings. 
 “Minimum Extension Condition” has the meaning assigned to such term in
Section 2.23(b). 
 “Moody’s” means Moody’s Investors Service, Inc. 

“Mortgage” means any mortgage, deed of trust, deeds to secure debt or other agreement which conveys or evidences a Lien in
favor of the Administrative Agent, for the benefit of the Administrative Agent and the relevant Secured Parties, on any Material Real Estate Asset constituting Collateral. 

“Mortgage Policy” has the meaning assigned to such term in the definition of “Real Estate Collateral Requirements”.

 “Multiemployer Plan” means any employee benefit plan which is a “multiemployer plan” as defined in
Section 3(37) of ERISA that is subject to the provisions of Title IV of ERISA, and in respect of which the Administrative Borrower or any of its Restricted Subsidiaries, or any of their respective ERISA Affiliates, 

  
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 distribution to or for the account of the Administrative Borrower or a Wholly-Owned Subsidiary as a result
thereof; and (b) with respect to any issuance or incurrence of Indebtedness or Capital Stock, the Cash proceeds thereof, net of all Taxes and customary fees, commissions, costs, underwriting discounts and other fees and expenses incurred in
connection therewith. 
 “New Jersey Loan Parties” means, collectively, inVentiv Commercial Services, LLC, a New Jersey
limited liability company, inVentiv Health Clinical Lab, Inc., a New Jersey corporation and Patient Marketing Group, LLC, a New Jersey limited liability company. 

“Non-Debt Fund Affiliate” means any Sponsor and any Affiliate of any such Sponsor, other than any Debt Fund Affiliate. 

“Non-Defaulting Revolving Lenders” has the meaning assigned to such term in Section 2.21(d)(i). 

“Non-Loan Party Cap” means the greater of $245,000,000 and 34% of Consolidated Adjusted EBITDA as of the last day of the most
recently ended Test Period. 
 “North Carolina Loan Parties” means, collectively, Addison Whitney LLC, a North Carolina
limited liability company, inVentiv Health Consulting, Inc., a North Carolina corporation and Pharmaceutical Institute, LLC, a North Carolina limited liability company. 

“Obligations” means all unpaid principal of and accrued and unpaid interest (including interest accruing during the pendency
of any bankruptcy, insolvency, receivership or other similar proceeding (or that would accrue but for the operation of applicable bankruptcy or insolvency laws), regardless of whether allowed or allowable in such proceeding) on the Loans, all LC
Exposure, all accrued and unpaid fees, premiums and all expenses (including fees, premiums and expenses accruing during the pendency of any bankruptcy, insolvency, receivership or other similar proceeding (or that would accrue but for the operation
of applicable bankruptcy or insolvency laws), regardless of whether allowed or allowable in such proceeding), reimbursements, indemnities and all other advances to, debts, liabilities and obligations of any Loan Party to the Lenders or to any
Lender, the Administrative Agent, any Issuing Bank or any indemnified party arising under the Loan Documents in respect of any Loan or Letter of Credit, whether direct or indirect (including those acquired by assumption), absolute, contingent, due
or to become due, now existing or hereafter arising. 
 “”Obligations Derivative Instrument” has the meaning specified in Section 9.05(e)(ii). 
 “OFAC” has the meaning assigned to such term in Section 3.17(a). 

“Ohio Loan Parties” means, collectively, inVentiv Communications Inc., an Ohio corporation, Blue Diesel, LLC, an Ohio limited
liability company, Cadent Medical Communications, LLC, an Ohio limited liability company, Gerbig, Snell/Weisheimer Advertising, LLC, an Ohio limited liability company, inVentiv Medical Communications, LLC, an Ohio limited liability company, Navicor
Group LLC, an Ohio limited liability company, Palio + Ignite, LLC, an Ohio limited liability company, The Selva Group, LLC, an Ohio limited liability company, Kendle Americas Investment, Inc., an Ohio corporation, and Kendle Americas Management
Inc., an Ohio corporation. 
 “Organizational Documents” means (a) with respect to any corporation, its certificate or
articles of incorporation or organization and its by-laws, (b) with respect to any limited partnership, its certificate of limited partnership and its partnership agreement, (c) with respect to any general partnership, its partnership
agreement, (d) with respect to any limited liability company, its articles of organization or certificate of formation, and its operating agreement, and (e) with respect to any other form of entity, such other organizational documents
required by local Requirements of Law or customary under such jurisdiction to document the formation and governance principles of such type of entity. In the event that any term or condition of this Agreement or any other Loan Document requires any
Organizational Document to be 

  
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 “Prepayment Asset Sale” means any Disposition by the Administrative
Borrower or its Restricted Subsidiaries made pursuant to Section 6.07(h). 
 “Prepayment Notice” means a notice
from the Administrative Borrower of any prepayment of any Borrowing of Term Loans pursuant to Section 2.11(a) substantially in the form attached hereto as Exhibit M or such other form that is reasonably acceptable to the
Administrative Agent. 
 “Primary Obligor” has the meaning assigned to such term in the definition of
“Guarantee”. 
 “Prime Rate” means
(a) the rate of interest
per annum publically announced from time to time by the Administrative Agent
as its prime commercial lending rate in effect at its principal office in New York City or (b) if the Administrative Agent has no “prime rate,” the rate of interest last quoted by The Wall Street Journal as the “Prime Rate” in the U.S. or, if The Wall Street Journal ceases to quote such rate, the highest per annum interest rate published by the
Board in Federal Reserve Statistical Release H.15 (519) (Selected Interest Rates) as the “bank prime loan” rate or, if such rate is no longer quoted therein, any similar rate quoted therein (as reasonably determined by the
Administrative Agent) or any similar release by the Board (as reasonably determined by the Administrative Agent). The Prime Rate is a reference rate and does not necessarily
represent the lowest or best rate actually charged to any customer. Any change in the prime rate determined by the Administrative Agent shall take effect at the opening of business on the date of such determinationEach change in the Prime Rate shall be effective from and including the date such change is
publicly announced or quoted as being effective. 
 “Pro Forma
Basis” or “pro forma effect” means, with respect to any determination of the Total Leverage Ratio, the First Lien Leverage Ratio, the Secured Leverage Ratio, the Interest Coverage Ratio, Consolidated Adjusted EBITDA or
Consolidated Total Assets (including component definitions thereof), that: 
 (a) (i) in the case of (A) any
Disposition of all or substantially all of the Capital Stock of any Restricted Subsidiary or any division and/or product line of the Administrative Borrower and/or any Restricted Subsidiary, (B) any designation of a Restricted Subsidiary as an
Unrestricted Subsidiary and (C) the implementation of any Business Optimization Initiative, income statement items (whether positive or negative and including any Expected Cost Savings) attributable to the property or Person subject to such
Subject Transaction shall be excluded as of the first day of the Test Period applicable to any test or covenant for which the relevant determination is being made and (ii) in the case of any Permitted Acquisition, Investment and/or designation
of an Unrestricted Subsidiary as a Restricted Subsidiary described in the definition of the term “Subject Transaction,” income statement items (whether positive or negative) attributable to the property or Person subject to such Subject
Transaction shall be included as of the first day of the applicable Test Period with respect to any test or covenant for which the relevant determination is being made; it being understood that any pro forma adjustment described in this Agreement
may be applied to any such test or covenant solely to the extent that such adjustment is consistent with the definition of “Consolidated Adjusted EBITDA,” 

(b) any retirement or repayment of Indebtedness shall be deemed to have occurred as of the first day of the Test Period
applicable to any test or covenant for which the relevant determination is being made, 
 (c) any Indebtedness incurred by
the Administrative Borrower or any of its Restricted Subsidiaries in connection therewith shall be deemed to have occurred as of the first day of the applicable Test Period with respect to any test or covenant for which the relevant determination is
being made; provided that, (i) if such Indebtedness has a floating or formula rate, such Indebtedness shall have an implied rate of interest for the applicable Test Period for purposes of this definition determined by utilizing the rate
that is or would be in effect with respect to such Indebtedness at the relevant date of determination (taking into account any interest hedging arrangements applicable to 

  
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 Applicable Country in which such Foreign Subsidiary is incorporated or organized) and all documents,
financing statements, agreements, instruments, certificates, notices and acknowledgements and filings which the Administrative Agent may reasonably request to ensure the creation, perfection and priority of the Liens on the assets of such Foreign
Subsidiary, in each case (i) in a form reasonably acceptable to the Administrative Agent, (ii) governed by the laws of the Applicable Country in which such Foreign Subsidiary is incorporated or organized and (iii) subject to customary
exceptions for transactions of this type in such Applicable Country), and any such Restricted Subsidiary shall be a Loan Party and Subsidiary Guarantor for all purposes hereunder. In the event that the Administrative Borrower elects to cause a
Foreign Subsidiary to be a Subsidiary Guarantor in accordance with the foregoing, such Foreign Subsidiary shall cease to be an Excluded Subsidiary for purposes of the Loan Documents and shall be deemed not to constitute a Foreign Subsidiary for
purposes of clause (h) of the definition of “Excluded Assets”, clause (h) of the definition of “Excluded Subsidiary” and the second paragraph of Section 3.14. 

“Successor Administrative Agent” has the meaning assigned to such term in Section 2.17(f)(iii). 

“Successor Borrower” has the meaning assigned to such term in Section 6.07(a). 

“Swap Obligations” means, with respect to any Loan Guarantor, any obligation to pay or perform under any agreement, contract
or transaction that constitutes a “swap” within the meaning of Section 1a(47) of the Commodity Exchange Act. 

“Taxes” means all present and future taxes, levies, imposts, duties, deductions, withholdings (including backup withholding),
assessments, fees or other charges imposed by any Governmental Authority, including any interest, additions to tax or penalties applicable thereto. 

“Term A Loan” means the Initial Term A Loans and any Additional Term Loans that are Customary Term A Loans. 

“Term A Loan Installment Date” has the meaning assigned to such term in Section 2.10(a)(i). 

“Term B Loan” means the Initial Term B Loans and any Additional Term Loans that are Customary Term B Loans. 

“Term B Loan Installment Date” has the meaning assigned to such term in Section 2.10(a)(ii). 

“Term Commitment” means any Initial Term Loan Commitment, any
Delayed Draw Term A Commitments and any Additional
Term Loan Commitment. 
 “Term Facility” means the Term Loans provided to or for the benefit of the Borrowers
pursuant to the terms of this Agreement. 
 “Term Lender” means any Initial Term Lender and any Additional Term Lender.

 “Term Loan” means the Initial Term Loans, Delayed Draw Term
A Loans and, if applicable, any Additional Term Loans. 
 “Termination
Date” has the meaning assigned to such term in the lead-in to Article 5. 
 “Test Period” means, as of any
date, (a) for purposes of determining actual compliance with Section 6.13(a), the period of four consecutive Fiscal Quarters then most recently ended for which financial statements under Section 5.01(a) or
Section 5.01(b), as applicable, have been delivered (or are required to have been delivered) and (b) for any other purpose, the period of four consecutive Fiscal Quarters then most recently ended for which financial statements of
the type described in Section 5.01(a) or Section 5.01(b), as 

  
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 Section 1.12. Divisions.
For all purposes under the Loan Documents, in connection with any division or plan of division under
Delaware law (or any comparable event under a different jurisdiction’s laws): (a) if any asset, right, obligation or liability of any Person becomes the asset, right, obligation or liability of a different Person, then it shall be deemed
to have been transferred from the original Person to the subsequent Person, and (b) if any new Person comes into existence, such new Person shall be deemed to have been organized on the first date of its existence by the holders of its Equity
Interests at such time. 
 ARTICLE 2 THE CREDITS 

Section 2.01. Commitments. 

(a) Subject to the terms and conditions set forth herein and in Amendment
No. 2, (i) each Initial Term A Lender severally, and not jointly, agrees to make initial term A loans to the Borrowers (the proceeds of which may be allocated between the Borrowers) on
the Amendment No. 2 Closing Date in Dollars in a principal amount not to exceed its Initial Term A Loan Commitment,
(ii) each Initial Term B Lender severally, and not jointly, agrees to make initial term B
loansReplacement Term B Loans (as defined in Amendment No. 1) to the Borrowers (the proceeds of which may be allocated between the Borrowers) on the 2018 Replacement Term B Closing Date in Dollars in a principal amount not to exceed its Initial Term B Loan Commitment and (iii) each Initial
Revolving Lender severally, and not jointly, agrees to make Initial Revolving Loans to the Borrowers (or any Borrower) in Dollars or any applicable Alternate Currency at any time and from time to time on and after the Amendment No. 2 Closing Date, and until the earlier of the Initial Revolving Credit Maturity Date and the termination of the Initial
Revolving Credit Commitment of such Initial Revolving Lender in accordance with the terms hereof; provided that, after giving effect to any Borrowing of Initial Revolving Loans, the Outstanding Amount of such Initial Revolving Lender’s
Initial Revolving Credit Exposure shall not exceed such Initial Revolving Lender’s Initial Revolving Credit Commitment. Within the foregoing limits and subject to the terms, conditions and limitations set forth herein, the Borrowers may borrow,
pay or prepay and re-borrow Revolving Loans. Amounts paid or prepaid in respect of the Term A Loans and Initial Term B Loans may not be re-borrowed. 

(b)
Subject to the terms and conditions expressly set forth herein and in Amendment No. 2, each Delayed
Draw Term A Lender severally agrees to make to the Borrowers on any Business Day during the period from the Business Day immediately following the Amendment No. 2 Closing Date through the Delayed Draw Term A Commitment Termination Date (such
period, the “Delayed Draw Term Loan Availability Period”) one or more Borrowings denominated in Dollars in an aggregate amount not to exceed at any time outstanding the amount of such Delayed Draw Term A Lender’s Delayed Draw
Term A Commitment. Amounts borrowed under this Section 2.01(b) and repaid or prepaid may not be re-borrowed. Each Borrowing consisting of a Borrowing of Delayed Draw Term A Loans made on the applicable Delayed Draw Term A Loan Funding Date
shall be in a minimum principal amount of $5,000,000 and in increments of $1,000,000 in excess thereof. 

(c) (b) Subject to the terms and conditions of this Agreement and any applicable Refinancing Amendment, Extension Amendment or
Incremental Facility Amendment, each Lender with an Additional Commitment of a given Class, severally and not jointly, agrees to make Additional Loans of such Class to the Borrowers, which Loans shall not exceed for any such Lender at the time of
any incurrence thereof the Additional Commitment of such Class of such Lender as set forth in the applicable Refinancing Amendment, Extension Amendment or Incremental Facility Amendment.
(it being understood and agreed, as described in the definition of the term “Class” set forth herein that, upon the funding of any Delayed Draw Term A Loans hereunder,
such Delayed Draw Term A Loans and the other Term A Loans shall constitute a single Class of Term A Loans hereunder). 

  
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 received by the Administrative Agent (by hand delivery, fax or other electronic transmission (including
“.pdf” or “.tiff”)) not later than (i) 1:00 p.m. three Business Days prior to the requested date of any Borrowing of or continuation of Adjusted Eurocurrency Rate Loans (or (x) two Business Days in the case of any
Adjusted Eurocurrency Rate Borrowing to be made on the Closing Date and (y) four Business Days in the case of any Adjusted Eurocurrency Rate Borrowing in any Alternate Currency other than Sterling or Euros) or any conversion of ABR Loans to
Adjusted Eurocurrency Rate Loans and (ii) 12:00 p.m. on the requested date of any Borrowing of or conversion to ABR Loans (or, in each case, such later time as is reasonably acceptable to the Administrative Agent); provided that, if the
Administrative Borrower wishes to request Adjusted Eurocurrency Rate Loans having an Interest Period of other than one, two, three or six months in duration as provided in the definition of “Interest Period” (A) the applicable
notice from the Administrative Borrower must be received by the Administrative Agent not later than 1:00 p.m. four Business Days prior to the requested date of the relevant Borrowing (or such later time as is reasonably acceptable to the
Administrative Agent), conversion or continuation, whereupon the Administrative Agent shall give prompt notice to the appropriate Lenders of such request and determine whether the requested Interest Period is available to them and (B) not later
than 12:00 p.m. three Business Days before the requested date of the relevant Borrowing, conversion or continuation, the Administrative Agent shall notify the Administrative Borrower whether or not the requested Interest Period is available to and
has been approved by the appropriate Lenders (such approval not to be unreasonably withheld or delayed). 
 (b) Each Borrowing Request will
specify the currency in which the relevant Loan will be made. If, with respect to any Loan denominated in Dollars, no election as to the Type of Borrowing is specified, then the requested Borrowing shall be an ABR Borrowing. If no Interest Period is
specified with respect to any requested Adjusted Eurocurrency Rate Borrowing, then the Borrowers shall be deemed to have selected an Interest Period of one month’s duration. The Administrative Agent shall advise each Lender of the details and
amount of any Loan to be made as part of the requested Borrowing (x) in the case of any ABR Borrowing, on the same Business Day of receipt of a Borrowing Request in accordance with this Section or (y) in the case of any Adjusted
Eurocurrency Rate Borrowing, no later than one Business Day following receipt of a Borrowing Request in accordance with this Section. No Revolving Loan may be converted into or continued as a Revolving Loan denominated in a different currency, but
instead must be repaid in the currency in which such Revolving Loan was originally denominated and re-borrowed in the relevant other currency. 

Section 2.04. [Reserved]. 

Section 2.05. Letters of Credit. 

(a) General. Subject to the terms and conditions set forth herein, (i) each Issuing Bank agrees, in each case in reliance upon the
agreements of the other Revolving Lenders set forth in this Section 2.05, (A) from time to time on any Business Day during the period from the Closing Date to the fifth Business Day prior to the Latest Revolving Credit Maturity
Date, upon the request of the Administrative Borrower, to issue Letters of Credit issued on sight basis only for the account of the Administrative Borrower and/or any of its subsidiaries (provided that one or more Borrowers will be a
co-applicant) and to amend or renew Letters of Credit previously issued by it, in accordance with Section 2.05(b), and (B) to honor drafts under the Letters of Credit, and (ii) the Revolving Lenders severally agree to
participate in the Letters of Credit issued pursuant to Section 2.05(d). On and after the Closing Date, each Existing Bank of America Closing Date Letter of Credit shall be deemed to be a Letter of Credit issued hereunder on the Closing Date for all purposes under this Agreement and the
other Loan Documents. On and after the Amendment No. 2 Closing Date, each Letter of Credit issued on and from the Closing Date that remains outstanding immediately prior to the Amendment No. 2 Closing Date shall be deemed to be a Letter of
Credit issued hereunder on the Amendment No. 2 Closing Date for all purposes under this Agreement and the other Loan Documents. No Issuing Bank shall be required to issue Commercial Letters
of Credit without its consent. 

  
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 (b) Notice of Issuance, Amendment, Renewal, Extension; Certain Conditions. To request
the issuance of any Letter of Credit, the Administrative Borrower shall deliver to the applicable Issuing Bank and the Administrative Agent, at least three Business Days in advance of the requested date of issuance (or such shorter period as is
acceptable to the applicable Issuing Bank or, in the case of any issuance to be made on the Closing Date, one Business Day prior to the Closing Date), a Letter of Credit Request. To request an amendment, extension or renewal of an outstanding Letter
of Credit (other than any automatic extension of a Letter of Credit permitted under Section 2.05(c)) the Administrative Borrower shall submit a Letter of Credit Request to the applicable Issuing Bank selected by the Administrative
Borrower (with a copy to the Administrative Agent) at least three Business Days in advance of the requested date of amendment, extension or renewal (or such shorter period as is acceptable to the applicable Issuing Bank), identifying the Letter of
Credit to be amended, extended or renewed, and specifying the proposed date (which shall be a Business Day) and other details of the amendment, extension or renewal. If requested by the applicable Issuing Bank in connection with any request for any
Letter of Credit, the Administrative Borrower also shall submit a letter of credit application on such Issuing Bank’s standard form. In the event of any inconsistency between the terms and conditions of this Agreement and the terms and
conditions of any form of letter of credit application or other agreement submitted by the Administrative Borrower to, or entered into by the Administrative Borrower with, the applicable Issuing Bank relating to any Letter of Credit, the terms and
conditions of this Agreement shall control. No Letter of Credit, letter of credit application or other document entered into by any Borrower with any Issuing Bank relating to any Letter of Credit shall contain any representation or warranty,
covenant or event of default not set forth in this Agreement (and to the extent inconsistent herewith shall be rendered null and void (or reformed automatically without further action by any Person to conform to the terms of this Agreement), and all
representations and warranties, covenants and events of default set forth therein shall contain standards, qualifications, thresholds and exceptions for materiality or otherwise consistent with those set forth in this Agreement (and, to the extent
inconsistent herewith, shall be deemed to automatically incorporate the applicable standards, qualifications, thresholds and exceptions set forth herein without action by any Person). No Letter of Credit may be issued, amended, extended or renewed
unless (and on the issuance, amendment, extension or renewal of each Letter of Credit the Administrative Borrower shall be deemed to represent and warrant that), after giving effect to such issuance, amendment, extension, or renewal
(i) (A) the LC Exposure does not exceed the Letter of Credit Sublimit (taking the Dollar Equivalent of the amount of any Letter of Credit denominated in an Alternate Currency), (B) with respect to any Letter of Credit to be issued by Credit SuisseJPMorgan Chase Bank, N.A., Wells Fargo Bank, N.A., PNC Bank, N.A., Bank of America, N.A. or ING
Capital LLC, the aggregate undrawn amount (plus unpaid LC Disbursements) of all outstanding Letters of Credit issued by
Credit Suisse does not exceed $100,000,000 and (C) with respect to any Letter of Credit to be issued by ING, the aggregate undrawn amount (plus unpaid LC Disbursements) of
all outstanding Letters of Credit issued by ING does not exceed $50,000,000 andJPMorgan Chase Bank, N.A., Wells Fargo Bank, N.A., PNC Bank, N.A., Bank of America, N.A. or
ING Capital LLC does not exceed $30,000,000 in each case and (ii) (A) the aggregate amount of the Initial Revolving Credit Exposure shall not exceed the aggregate amount of the Initial Revolving
Credit Commitments then in effect, (B) the aggregate amount of the Additional Revolving Credit Exposure attributable to any Class of Additional Revolving Credit Commitments does not exceed the aggregate amount of the Additional Revolving Credit
Commitments of such Class then in effect and (C) if such Letter of Credit has a term that extends beyond the Maturity Date applicable to the Revolving Credit Commitments of any Class, the aggregate amount of the LC Exposure attributable to
Letters of Credit expiring after such Maturity Date does not exceed the aggregate amount of the Revolving Credit Commitments then in effect that are scheduled to remain in effect after such Maturity Date. 

  
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 (f) It is understood and agreed that (i) only a Borrowing denominated in Dollars may be
made in the form of, or converted into, an ABR Loan and (ii) a Borrowing denominated in an Alternate Currency may only be made in the form of, or converted into, or continued as, an Adjusted Eurocurrency Rate Loan (or such other type of
Revolving Loan as may be agreed by the Administrative Agent and the Administrative Borrower pursuant to Section 1.11). No Revolving Loan may be converted into or continued as a Revolving Loan denominated in a different currency, but
instead must be prepaid in the original currency of such Revolving Loan and reborrowed in the other currency. 
 Section 2.09.
Termination and Reduction of Commitments. 
 (a) Unless previously terminated, (i) the Initial Term Loan Commitments on the
Closing Date shall automatically terminate upon the making of the Initial Term Loans on the Closing Date, (ii) the Initial Term A Loan Commitments shall automatically terminate upon
the making of the Initial Term A Loans on the Amendment No. 2 Closing Date, (iii) the Initial Revolving Credit Commitments shall automatically terminate on the Initial Revolving Credit
Maturity Date, (iii)iv) the Delayed Draw Term A Loan Commitments shall automatically terminate upon
the earlier of making of the Delayed Draw Term A Loans and the Delayed Draw Term A Commitment Termination Date, (v) the Additional Term Loan Commitments of any Class shall automatically
terminate upon the making of the Additional Term Loans of such Class and, if any such Additional Term Loan Commitment is not drawn on the date that such Additional Term Loan Commitment is required to be drawn pursuant to the applicable Incremental
Facility Amendment, Extension Amendment or Refinancing Amendment, as applicable, the undrawn amount thereof shall automatically terminate and (ivv) the Additional Revolving Credit Commitments of any Class shall automatically terminate on the Maturity Date specified therefor in the
applicable Incremental Facility Amendment, Extension Amendment or Refinancing Amendment, as applicable. 
 (b) Upon delivery of the
notice required by Section 2.09(c), the Administrative Borrower may at any time terminate or from time to time reduce, the Delayed Draw Term A Loan Commitment and/or the
Revolving Credit Commitments of any Class; provided that (i) each reduction of the Delayed Draw Term A Loan
Commitment and/or the Revolving Credit Commitments of any Class shall be in an amount that is an integral multiple of $1,000,000 and not less than $1,000,000 and (ii) the Administrative
Borrower shall not terminate or reduce the Revolving Credit Commitments of any Class if, after giving effect to any concurrent prepayment of Revolving Loans, the aggregate amount of the Revolving Credit Exposure attributable to the Revolving Credit
Commitments of such Class would exceed the aggregate amount of the Revolving Credit Commitments of such Class; provided that, after the establishment of any Additional Revolving Credit Commitment, any such termination or reduction of the
Revolving Credit Commitments of any Class shall be subject to the provisions set forth in Section 2.22, 2.23 and/or 9.02, as applicable. 

(c) The Administrative Borrower shall notify the Administrative Agent of any election to terminate or reduce the Delayed Draw Term A Loan Commitment and/or any Revolving Credit Commitment under paragraph (b) of this Section in writing at
least three Business Days prior to the effective date of such termination or reduction (or such later date to which the Administrative Agent may agree), specifying such election and the effective date thereof. Promptly following receipt of any such
notice, the Administrative Agent shall advise the Delayed Draw Term A Lenders and/or the Revolving Lenders of each applicable
Class of the contents thereof. Each notice delivered by the Administrative Borrower pursuant to this Section shall be irrevocable; provided that any such notice may state that it is conditioned upon the effectiveness of other transactions, in
which case such notice may be revoked or its effectiveness deferred by the Administrative Borrower (by notice to the Administrative Agent on or prior to the specified effective date) if such condition is not satisfied. Any termination or reduction
of the Delayed Draw Term A Loan Commitment and/or any Revolving Credit Commitment pursuant to this Section 2.09
shall be permanent. Upon any reduction of the Delayed Draw Term A Loan Commitment and/or any Revolving Credit Commitment, the
Delayed Draw Term A Loan Commitment of each Delayed Draw Term A Lender and/or Revolving Credit Commitment of each Revolving
Lender of the relevant Class shall be reduced by such Revolving Lender’s Applicable Percentage of such reduction
amount. 

  
 90 

 Section 2.10. Repayment of Loans; Evidence of Debt. 

(a) (i) The Borrowers hereby jointly and severally unconditionally promise to repay the outstanding principal amount of the Initial Term A
Loans funded on the Amendment No. 2 Closing Date and any Delayed Draw Term A Loans to the Administrative Agent for the account of
each Initialapplicable Term A Lender
(i) on the last Business Day of each April, July, October and January prior to the Initial Term A Loan Maturity Date (each such date being referred to as a “Term A Loan Installment Date”), in the principal amount set forth
below for such Term A Loan Installment Date (as such payment may be reduced from time to time as a result of the application of prepayments in accordance with Section 2.11 and/or any repurchase in accordance with
Section 9.05(f) or increased as a result of any increase in the amount of such Initial Term A Loans pursuant to Section 2.22(a) or in connection with the funding of any Delayed Draw Term A Loans), and (ii) on the Initial Term A
Loan Maturity Date, in an amount equal to the remainder of the principal amount of the Initial Term A Loans outstanding on such date, together in each case with accrued and unpaid interest on the principal amount to be paid to but excluding the date
of such payment. Notwithstanding the foregoing, from the date of funding any Delayed Draw Term A Loans, the amount set forth above in clause (i) shall be increased to an amount
necessary to cause the relevant Delayed Draw Term A Loans to be entitled to scheduled amortization payments representing the same percentage of the principal amount of such Delayed Draw Term A Loans as the amortization percentage that is applicable
to then outstanding Term A Loans prior to the Borrowing of the relevant Delayed Draw Term A Loan, it being understood that (A) such amendment will be effected immediately upon written notice thereof by the Administrative Agent to the Administrative Borrower and (B) no such amendment shall result in the decrease of
the amortization applicable to any Initial Term Loans outstanding prior to the Borrowing of the relevant Delayed Draw Term A Loan. 

 

					
	 TERM A LOAN INSTALLMENT DATE
	  	PRINCIPAL AMOUNT	 
	 Last Business Day of April 2019
	  	$	0	 
	 Last Business Day of July 2019
	  	$	0	 
	 Last Business Day of October 2019
	  	$	0	 
	 Last Business Day of January 20182020
	  	$	6,250,0000	 
	 Last Business Day of April
20182020
	  	$	6,250,00014,375,000	 
	 Last Business Day of July
20182020
	  	$	6,250,00014,375,000	 
	 Last Business Day of October 20182020
	  	$	6,250,00014,375,000	 
	 Last Business Day of January 20192021
	  	$	12,500,00014,375,000	 
	 Last Business Day of April
20192021
	  	$	12,500,00021,562,500	 
	 Last Business Day of July
20192021
	  	$	12,500,00021,562,500	 
	 Last Business Day of October 20192021
	  	$	12,500,00021,562,500	 

  
 91 

					
	 TERM A LOAN INSTALLMENT DATE
	  	PRINCIPAL AMOUNT	 
	 Last Business Day of January 20202022
	  	$	18,750,00021,562,500	 
	 Last Business Day of April
20202022
	  	$	18,750,00028,750,000	 
	 Last Business Day of July
20202022
	  	$	18,750,00028,750,000	 
	 Last Business Day of October 20202022
	  	$	18,750,00028,750,000	 
	 Last Business Day of January 20212023
	  	$	25,000,00028,750,000	 
	 Last Business Day of ril
20212023
	  	$	25,000,00028,750,000	 
	 Last Business Day of July
20212023
	  	$	25,000,00028,750,000	 
	 Last Business Day of October 20212023
	  	$	25,000,00028,750,000	 
	 Last Business Day of January 20222024
	  	$	25,000,00028,750,000	 
	 Last Business Day of April
2022Maturity Date
	  	$	25,000,000776,250,000	 
	 Last Business Day of July 2022
	  	$	25,000,000	 

 (ii) The Borrowers hereby jointly and severally unconditionally promise to repay the
outstanding principal amount of the Initial Term B Loans to the Administrative Agent for the account of each Term B Lender (i) commencing on the last Business Day of January 2018, on the last Business Day of each April, July, October and
January prior to the Initial Term B Loan Maturity Date (each such date being referred to as a “Term B Loan Installment Date”), in each case in an amount equal to 0.25% of the original principal amount of the Initial Term B Loans (as
such payments may be reduced from time to time as a result of the application of prepayments in accordance with Section 2.11 and/or any repurchase in accordance with Section 9.05(f)), and (ii) on the Initial Term B Loan
Maturity Date, in an amount equal to the remainder of the principal amount of the Initial Term B Loans outstanding on such date, together in each case with accrued and unpaid interest on the principal amount to be paid to but excluding the date of
such payment. 
 (iii) The Borrowers shall, jointly and severally, repay the Additional Term Loans of any Class in such
scheduled amortization installments and on such date or dates as shall be specified therefor in the applicable Incremental Facility Amendment, Extension Amendment or Refinancing Amendment (as such payments may be reduced from time to time as a
result of the application of prepayments in accordance with Section 2.11 or purchases or assignments in accordance with Section 9.05(f) or increased as a result of any increase in the amount of such Additional Term Loans of
such Class pursuant to Section 2.22(a)). 
 (b) (i) The Borrowers hereby, jointly and severally, unconditionally promise to
pay, in Dollars or the relevant Alternate Currency, (A) to the Administrative Agent for the account of each Initial Revolving Lender, the then-unpaid principal amount of the Initial Revolving Loans of such Lender on the Initial

  
 92 

 
after the date on which the Revolving Credit Commitments of the applicable Class terminate shall be payable on demand. Any other fees payable to any Issuing Bank pursuant to this paragraph shall
be payable within 30 days after receipt of a written demand (accompanied by reasonable back-up documentation) therefor. 
 (c) The
Administrative Borrower agrees to pay to the Administrative Agent, for its own account, the annual administration fee described in the Fee LettersLetter. 
 (d) All fees
payable hereunder shall be paid on the dates due, in Dollars and in immediately available funds, to the Administrative Agent (or to the applicable Issuing Bank, in the case of fees payable to any Issuing Bank). Fees paid shall not be refundable
under any circumstances except as otherwise provided in the Fee LettersLetter. Fees payable hereunder shall accrue through and including the last day of the month immediately preceding the applicable fee payment date. 

(e) In the event that, prior to the date that is six months after the 2018 Replacement Term B Closing Date, any Borrower (A) prepays,
repays, refinances, substitutes or replaces any Initial Term B Loans in connection with a Repricing Transaction (including, for the avoidance of doubt, any prepayment made pursuant to Section 2.11(b)(iii) that constitutes a Repricing
Transaction), or (B) effects any amendment, modification or waiver of, or consent under, this Agreement resulting in a Repricing Transaction, the Borrowers shall pay to the Administrative Agent, for the ratable account of each applicable
Initial Term B Lender, (I) in the case of clause (A), a premium of 1.00% of the aggregate principal amount of the Initial Term B Loans so prepaid, repaid, refinanced, substituted or replaced and (II) in the case of clause (B), a fee equal to
1.00% of the aggregate principal amount of the Initial Term B Loans that are the subject of such Repricing Transaction outstanding immediately prior to such amendment. If, prior to the date that is six months after the 2018 Replacement Term B
Closing Date, all or any portion of the Initial Term B Loans held by any Initial Term B Lender are prepaid, repaid, refinanced, substituted or replaced pursuant to Section 2.19(b)(iv) as a result of, or in connection with, such Initial Term B
Lender not agreeing or otherwise consenting to any waiver, consent, modification or amendment referred to in clause (B) above (or otherwise in connection with a Repricing Transaction), such prepayment, repayment, refinancing, substitution or
replacement will be made at 101% of the principal amount so prepaid, repaid, refinanced, substituted or replaced. All such amounts shall be due and payable on the date of effectiveness of such Repricing Transaction in Dollars and in immediately
available funds. 
 (f) The Borrowers, jointly and severally, agree to pay to
the Administrative Agent, for the account of each Delayed Draw Term A Lender holding Delayed Draw Term A
Commitments, a commitment fee (the “Delayed Draw Term A Loan Commitment Fee”) in Dollars which shall accrue at a per annum rate equal to 0.375% on such Delayed Draw Term A Loan Commitment on the actual daily amount of the unused
Delayed Draw Term A Loan Commitment of such Delayed Draw Term A Lender. The Delayed Draw Term A Loan Commitment Fee shall be payable in arrears on the last Business Day of each calendar quarter in each year from the Amendment No. 2 Closing Date
until (and including) the Delayed Draw Term A Loan Termination Date. The Delayed Draw Term A Loan Commitment Fee shall be computed on the basis of the actual number of days elapsed in a year of 360 days. The Delayed Draw Term A Loan Commitment Fee
due to each Delayed Draw Term A Lender shall begin to accrue on the Amendment No. 2 Closing Date and shall cease to accrue on the Delayed Draw Term A Loan Termination Date. 

(g) (f) Unless
otherwise indicated herein, all computations of fees shall be made on the basis of a 360- day year and shall be payable for the actual days elapsed (including the first day but excluding the last day). The determination by the Administrative Agent
of the amount of any fee hereunder shall be conclusive and binding for all purposes, absent manifest error. 
 Section 2.13.
Interest. 
 (a) The Term Loans and Revolving Loans comprising each ABR Borrowing shall bear interest at the Alternate Base Rate
plus the Applicable Rate. 

  
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 (b) The Term Loans and Revolving Loans comprising each Adjusted Eurocurrency Rate Borrowing
shall bear interest at the Adjusted Eurocurrency Rate for the Interest Period in effect for such Borrowing plus the Applicable Rate. 

(c) [Reserved]. 
 (d)
Notwithstanding the foregoing, if any principal of or interest on any Term Loan or Revolving Loan, any LC Disbursement or any fee payable by any Borrower hereunder is not, in each case, paid or reimbursed when due, whether at stated maturity, upon
acceleration or otherwise, the relevant overdue amount shall bear interest, to the fullest extent permitted by applicable Requirements of Law, after as well as before judgment, at a rate per annum equal to (i) in the case of overdue principal
or interest of any Term Loan, Revolving Loan or unreimbursed LC Disbursement, 2.00% plus the rate otherwise applicable to such Term Loan, Revolving Loan or LC Disbursement as provided in the preceding paragraphs of this Section or
(ii) in the case of any other amount, 2.00% plus the rate applicable to Revolving Loans that are ABR Loans as provided in paragraph (a) of this Section; provided that no amount shall accrue pursuant to this
Section 2.13(d) on any overdue amount, reimbursement obligation in respect of any LC Disbursement or other amount payable to a Defaulting Lender so long as such Lender is a Defaulting Lender. 

(e) Accrued interest on each Term Loan and Revolving Loan shall be payable in arrears on each Interest Payment Date for such Term Loan or
Revolving Loan and (i) on the Maturity Date applicable to such Loan and (ii) in the case of a Revolving Loan of any Class, upon termination of the Revolving Credit Commitments of such Class; provided that (A) interest accrued
pursuant to paragraph (d) of this Section shall be payable on demand, (B) in the event of any repayment or prepayment of any Term Loan or Revolving Loan, (other than an ABR Revolving Loan of any Class prior to the termination of the
Revolving Credit Commitments of such Class), accrued interest on the principal amount repaid or prepaid shall be payable on the date of such repayment or prepayment and (C) in the event of any conversion of any Adjusted Eurocurrency Rate Loan
prior to the end of the current Interest Period therefor, accrued interest on such Term Loan or Revolving Loan shall be payable on the effective date of such conversion. 

(f) All interest hereunder shall be computed on the basis of a year of 360 days, except that interest computed by reference to the Alternate
Base Rate at times when the Alternate Base Rate is based on the Prime Rate shall be computed on the basis of a year of 365 days (or 366 days in a leap year), and in each case shall be payable for the actual number of days elapsed (including the
first day but excluding the last day). The applicable Alternate Base Rate and Adjusted Eurocurrency Rate shall be determined by the Administrative Agent, and such determination shall be conclusive absent manifest error. Interest shall accrue on each
Loan for the day on which the Loan is made and shall not accrue on a Loan, or any portion thereof, for the day on which the Loan or such portion is paid; provided that any Loan that is repaid on the same day on which it is made shall bear
interest for one day. 
 Section 2.14. Alternate Rate of Interest. 

(a) If prior to the first day
of any Interest Period for an Adjusted Eurocurrency Rate Borrowing: 
 (i) (a) the Administrative Agent determines (which
determination shall be conclusive absent manifest error) that adequate and reasonable means do not exist for ascertaining the Adjusted Eurocurrency Rate for such Interest Period; or 

(ii) (b) the Administrative Agent is advised by the Required Lenders that the Adjusted Eurocurrency Rate for such Interest Period will
not adequately and fairly reflect the cost to such Lenders of making or maintaining their Loans included in such Borrowing for such Interest Period; 

then the Administrative Agent shall give notice thereof to the Administrative Borrower and the Lenders by telephone or facsimile as promptly as
practicable thereafter (but at least two Business 

  
 101 

 Days prior to the first day of such Interest Period). If such notice is given then until the
Administrative Agent notifies the Administrative Borrower and the Lenders that the circumstances giving rise to such notice no longer exist, which the Administrative Agent agrees promptly to do, (i) any Interest Election Request that requests
the conversion of any Borrowing to, or continuation of any Borrowing as, an Adjusted Eurocurrency Rate Borrowing shall be ineffective and such Borrowing shall be converted to an ABR Borrowing (or, in the case of a pending request for a Borrowing
denominated in any Alternate Currency, the Administrative Borrower and the Revolving Lenders shall establish a mutually acceptable alternative rate) on the last day of the Interest Period applicable thereto, and (ii) if any Borrowing Request
requests an Adjusted Eurocurrency Rate Borrowing, such Borrowing shall be made as an ABR Borrowing (or, in the case of a pending request for a Borrowing denominated in any Alternate Currency, the Administrative Borrower and the Revolving Lenders
shall establish a mutually acceptable alternative rate). 
 (b) If at any time
the Administrative Agent determines (which determination shall be conclusive absent manifest error), with respect to Term A Loans and/or Revolving Loans under Revolving Credit Commitments only, that (i) the circumstances set forth in clause
(a)(i) have arisen and such circumstances are unlikely to be temporary or (ii) the circumstances set forth in clause (a)(i) have not arisen but either (w) the supervisor for the administrator of the Adjusted Eurocurrency Rate has made a
public statement that the administrator of the Adjusted Eurocurrency Rate is insolvent (and there is no successor administrator that will continue publication of the Adjusted Eurocurrency Rate), (x) the administrator of the Adjusted
Eurocurrency Rate has made a public statement identifying a specific date after which the Adjusted Eurocurrency Rate will permanently or indefinitely cease to be published by it (and there is no successor administrator that will continue publication
of the Adjusted Eurocurrency Rate), (y) the supervisor for the administrator of the Adjusted Eurocurrency Rate has made a public statement identifying a specific date after which the Eurocurrency Rate will permanently or indefinitely cease to
be published or (z) the supervisor for the administrator of the Adjusted Eurocurrency Rate or a Governmental Authority having jurisdiction over the Administrative Agent has made a public statement identifying a specific date after which the Eurocurrency Rate may no longer be used for determining interest rates for loans, then the Administrative Agent and the
Administrative Borrower shall endeavor to establish an alternate rate of interest to the Eurocurrency Rate that gives due consideration to the then prevailing market convention for determining a rate of interest for syndicated loans in the United
States at such time, and shall enter into an amendment to this Agreement to reflect such alternate rate of interest and such other related changes that are necessary or appropriate in the opinion of the Administrative Agent and the Administrative
Borrower to give effect to this Section 2.14(b) (but for the avoidance of doubt, such related changes shall not include a reduction of the Applicable Rate); provided that, if such alternate rate of interest as so determined would be less than
zero, such rate shall be deemed to be zero for the purposes of this Agreement. Notwithstanding anything to the contrary in Section 9.02(b), such amendment shall become effective without any further action or consent of any other party to this
Agreement so long as the Administrative Agent shall not have received, within five Business Days of the date that such amendment is posted to the Lenders, a written notice from the Required Lenders of each Class stating that such Required Lenders
object to such amendment. Until an alternate rate of interest shall be determined in accordance with this clause (b) (but, in the case of the circumstances described in clause (ii)(w), clause (ii)(x) or clause (ii)(y) of the first sentence of
this Section 2.14(b), only to the extent the Adjusted Eurocurrency Rate for the applicable currency and such Interest Period is not available or published at such time on a current basis), (x) any Interest Election Request that requests
the conversion of any Revolving Borrowing to, or continuation of any Borrowing of Revolving Loans as, a Borrowing Adjusted Eurocurrency Rate Loans shall be ineffective, (y) if any Borrowing requests a Borrowing of Revolving Loans at the
Adjusted Eurocurrency Rate, such Borrowing shall be made as an ABR Borrowing and (z) any request by the Borrower for a Borrowing of Adjusted Eurocurrency Rate Loans shall be ineffective.

  
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 provide a U.S. Tax Compliance Certificate substantially in the form of Exhibit L-23 on behalf of each such direct or indirect partner;

 (C) each Foreign Lender shall deliver to the Administrative Borrower and the Administrative Agent on or prior to
the date on which such Foreign Lender becomes a Lender under this Agreement (and from time to time thereafter upon the reasonable request of the Administrative Borrower or the Administrative Agent), two executed original copies of any other form
prescribed by applicable Requirements of Law as a basis for claiming exemption from or a reduction in U.S. federal withholding Tax, duly completed, together with such supplementary documentation as may be prescribed by applicable Requirements of Law
to permit the Administrative Borrower or the Administrative Agent to determine the withholding or deduction required to be made; and 

(D) if a payment made to any Lender under any Loan Document would be subject to U.S. federal withholding Tax imposed by FATCA
if such Lender were to fail to comply with the applicable reporting requirements of FATCA (including those contained in Section 1471(b) or 1472(b) of the Code, as applicable), such Lender shall deliver to the Administrative Borrower and the
Administrative Agent at the time or times prescribed by applicable Requirements of Law and at such time or times reasonably requested by the Administrative Borrower or the Administrative Agent such documentation as is prescribed by applicable
Requirements of Law (including as prescribed by Section 1471(b)(3)(C)(i) of the Code) as may be necessary for the Administrative Borrower and the Administrative Agent to comply with their obligations under FATCA, to determine whether such
Lender has complied with such Lender’s obligations under FATCA or to determine the amount, if any, to deduct and withhold from such payment. 

(iii) In the event that a successor to the Administrative Agent (a “Successor Administrative Agent”) is not an
“exempt recipient” (within the meaning of Treas. Reg. 1.6049- 4(c)(1)(ii)), on or before the date such Successor Administrative Agent becomes a party to this Agreement, such Successor Administrative Agent shall deliver to Administrative
Borrower whichever of the following is applicable: (i) if the Successor Administrative Agent is a “United States person” within the meaning of Section 7701(a)(30) of the Code, two executed original copies of IRS Form W-9
certifying that such Successor Administrative Agent is exempt from U.S. federal backup withholding or (ii) if the Successor Administrative Agent is not a “United States person” within the meaning of Section 7701(a)(30) of the
Code, (A) with respect to payments received for its own account, two executed original copies of IRS Form W-8ECI and (B) with respect to payments received on account of any Lender, two executed original copies of IRS Form W-8IMY (together
with all required accompanying documentation) certifying that the Successor Administrative Agent is a U.S. branch and may be treated as a United States person for purposes of applicable U.S. federal withholding Tax. At any time thereafter, the
Successor Administrative Agent shall provide updated documentation previously provided (or a successor form thereto) when any documentation previously delivered has expired or become obsolete or invalid or otherwise upon the reasonable request of
the Borrower. 
 Each Lender agrees that if any documentation it previously delivered expires or becomes obsolete or inaccurate in any respect, it shall
update such documentation or promptly notify the Administrative Borrower and the Administrative Agent in writing of its legal ineligibility to do so. 
 For
the avoidance of doubt, if a Lender is an entity disregarded from its owner for U.S. federal income tax purposes, references to the foregoing documentation are intended to refer to documentation with respect to such Lender’s owner and, as
applicable, such Lender. 

  
 107 

 Notwithstanding anything to the contrary in this Section 2.17(f), no Lender shall be required to
provide any documentation that such Lender is not legally eligible to deliver. 
 (g) If the Administrative Agent or any Lender determines,
in its sole discretion exercised in good faith, that it has received a refund of any Indemnified Taxes as to which it has been
indemnified by the Borrowers or with respect to which the Borrowers have paid additional amounts pursuant to this Section 2.17, it shall pay over such refund to the Administrative Borrower (but only to the extent of indemnity payments
made, or additional amounts paid, by the Borrowers under this Section 2.17 with respect to the Indemnified Taxes giving rise to such refund), net of all out-of-pocket expenses of the Administrative Agent or such Lender (including any
Taxes imposed with respect to such refund), and without interest (other than any interest paid by the relevant Governmental Authority with respect to such refund); provided that the Borrowers, upon the request of the Administrative Agent or such
Lender, jointly and severally agree to repay the amount paid over to such Loan Party (plus any penalties, interest or other charges imposed by the relevant Governmental Authority) to the Administrative Agent or such Lender in the event the
Administrative Agent or such Lender is required to repay such refund to such Governmental Authority. Notwithstanding anything to the contrary in this paragraph (g), in no event will the Administrative Agent or any Lender be required to pay
any amount to the Borrowers pursuant to this paragraph (g) to the extent that the payment thereof would place the Administrative Agent or such Lender in a less favorable net after-Tax position than the position that the Administrative
Agent or such Lender would have been in if the Tax subject to indemnification had not been deducted, withheld or otherwise imposed and the indemnification payments or additional amounts giving rise to such refund had never been paid. This
Section 2.17 shall not be construed to require the Administrative Agent or any Lender to make available its Tax returns (or any other information relating to its Taxes which it deems confidential) to the relevant Loan Party or any other
Person. 
 (h) Survival. Each party’s obligations under this Section 2.17 shall survive the resignation or
replacement of the Administrative Agent or any assignment of rights by, or the replacement of, any Lender, the termination of the Commitments and the repayment, satisfaction or discharge of all obligations under any Loan Document. 

Section 2.18. Payments Generally; Allocation of Proceeds; Sharing of Payments. 

(a) Unless otherwise specified, the Borrowers shall make each payment required to be made by them hereunder (whether of principal, interest or
fees, reimbursements of LC Disbursements, or of amounts payable under Section 2.15, 2.16 or 2.17, or otherwise) prior to 3:00 p.m. on the date when due, in immediately available funds or such other form of consideration as
the relevant Lender may agree, without set-off or counterclaim. Any amounts received after such time on any date may, in the discretion of the Administrative Agent, be deemed to have been received on the next succeeding Business Day for purposes of
calculating interest thereon. All such payments shall be made to the Administrative Agent to the applicable account designated by the Administrative Agent to the Administrative Borrower, except that payments pursuant to Sections 2.15,
2.16, 2.17 and 9.03 shall be made directly to the Person or Persons entitled thereto. The Administrative Agent shall distribute any such payments received by it for the account of any other Person to the appropriate recipient
promptly following receipt thereof. Except as provided in Sections 2.19(b) and 2.20, each Borrowing, each payment or prepayment of principal of any Borrowing, each payment of interest on the Loans of a given Class and each conversion
of any Borrowing or continuation of any Borrowing as a Borrowing of any Type (and of the same Class) shall be allocated pro rata among the Lenders in accordance with their respective Applicable Percentages of the applicable Class. All payments
(including accrued interest) made hereunder in immediately available funds shall be made in Dollars or, in the case of payments on Loans made in an Alternate Currency, the relevant Alternate Currency. Each Lender agrees that in computing such
Lender’s portion of any Borrowing to be made hereunder, the Administrative Agent may, in its discretion, round each Lender’s share of such Borrowing to the next higher or lower whole Dollar amount (or the whole amount denominated in the
relevant Alternate Currency). Any payment required to be made by the Administrative Agent hereunder shall be deemed to have been made by the time required if the Administrative Agent shall, at or before such time, have taken the necessary steps to
make such payment in accordance with 

  
 108 

 subsequent reallocation of LC Exposure among non-Defaulting Lenders described in clause
(i) above); 
 (iii) if the LC Exposure of the Non-Defaulting Revolving Lenders is reallocated pursuant to this
Section 2.21(d), then the fees payable to the Revolving Lenders pursuant to Sections 2.12(a) and (b), as the case may be, shall be adjusted to give effect to such reallocation; and 

(iv) if any Defaulting Lender’s LC Exposure is not Cash collateralized, prepaid or reallocated pursuant to this
Section 2.21(d), then, without prejudice to any rights or remedies of the applicable Issuing Bank or any Revolving Lender hereunder, all letter of credit fees payable under Section 2.12(b) with respect to such Defaulting
Lender’s LC Exposure shall be payable to the applicable Issuing Bank until such Defaulting Lender’s LC Exposure is Cash collateralized or reallocated. 

(e) So long as any Revolving Lender is a Defaulting Lender, no Issuing Bank shall be required to issue, extend, create, incur, amend or
increase any Letter of Credit unless it is reasonably satisfied that the related exposure will be 100% covered by the Revolving Credit Commitments of the Non-Defaulting Revolving Lenders, Cash collateral provided pursuant to
Section 2.21(c) and/or Cash collateral provided in accordance with Section 2.21(d), and participating interests in any such or newly issued, extended or created Letter of Credit shall be allocated among Non-Defaulting
Revolving Lenders in a manner consistent with Section 2.21(d)(i) (it being understood that Defaulting Lenders shall not participate therein). 

(f) In the event that the Administrative Agent and the Administrative Borrower agree that any Defaulting Lender has adequately remedied all
matters that caused such Lender to be a Defaulting Lender, then the Applicable Revolving Credit Percentage of LC Exposure of the Revolving Lenders shall be readjusted to reflect the inclusion of such Lender’s Revolving Credit Commitment, and on
such date such Revolving Lender shall purchase at par such of the Revolving Loans of the applicable Class of the other Revolving Lenders or participations in Revolving Loans of the applicable Class as the Administrative Agent determine as necessary
in order for such Revolving Lender to hold such Revolving Loans or participations in accordance with its Applicable Percentage of the applicable Class or its Applicable Revolving Credit Percentage, as applicable. Notwithstanding the fact that any
Defaulting Lender has adequately remedied all matters that caused such Lender to be a Defaulting Lender, (x) no adjustment will be made retroactively with respect to fees accrued or payments made by or on behalf of Borrower while such Lender
was a Defaulting Lender and (y) except to the extent otherwise expressly agreed by the affected parties, no change hereunder from Defaulting Lender to Lender will constitute a waiver or release of any claim of any party hereunder arising from
such Lender’s having been a Defaulting Lender. 
 Section 2.22. Incremental Credit Extensions. 

(a) The Borrowers may, at any time, on one or more occasions pursuant to an Incremental Facility Amendment (i) add one or more new
tranches of term facilities and/or increase the principal amount of the Term Loans of any existing Class by requesting new commitments to provide such Term Loans (any such new tranche or increase, an “Incremental Term Facility” and
any loans made pursuant to an Incremental Term Facility, “Incremental Term Loans”) and/or (ii) add one or more new tranches of Incremental Revolving Commitments and/or increase the aggregate amount of the Revolving Credit
Commitments of any existing Class (any such new tranche or increase, an “Incremental Revolving Facility” and, together with any Incremental Term Facility, “Incremental Facilities”; and the loans thereunder,
“Incremental Revolving Loans” and any Incremental Revolving Loans, together with any Incremental Term Loans, “Incremental Loans”) in an aggregate outstanding principal amount not to exceed, with respect to any Incremental Loans
established after the Amendment No. 2 Closing Date, the Incremental Cap; provided that: 

  
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 Authority; and (ii) no Borrower has or will directly or, to its knowledge, indirectly, use the proceeds
of the Initial Term Loans or otherwise make available such proceeds to any governmental official or employee, political party, official of a political party, candidate for public office or anyone else acting in an official capacity, in order to
obtain, retain or direct business or obtain any improper advantage in violation of the FCPA or any applicable anti-corruption Requirement of Law of any Governmental Authority. 

The representations and warranties set forth in Section 3.17 above made by or on behalf of any Foreign Subsidiary are subject to
and limited by any Requirement of Law applicable to such Foreign Subsidiary; it being understood and agreed that to the extent that any Foreign Subsidiary is unable to make any representation or warranty set forth in Section 3.17 as a
result of the application of this sentence, such Foreign Subsidiary shall be deemed to have represented and warranted that it is in compliance, in all material respects, with any equivalent Requirement of Law relating to Sanctions, anti-terrorism,
anti-corruption or anti-money laundering that is applicable to such Foreign Subsidiary in its relevant local jurisdiction of organization. 

ARTICLE 4 CONDITIONS 

Section 4.01. Closing Date. The obligations of (i) each Lender to make Loans and (ii) any Issuing Bank to issue Letters
of Credit shall not become effective until the date on which each of the following conditions is satisfied (or waived in accordance with Section 9.02): 

(a) Credit Agreement and Loan Documents. The Administrative Agent (or its counsel) shall have received from each Loan Party party
thereto (i) a counterpart signed by such Loan Party (or written evidence reasonably satisfactory to the Administrative Agent (which may include a copy transmitted by facsimile or other electronic method) that such party has signed a
counterpart) of (A) this Agreement, (B) the Security Agreement, (C) the Loan Guaranty, (D) any Intellectual Property Security Agreement and (E) any Promissory Note requested by a Lender at least three Business Days prior to
the Closing Date and (ii) a Borrowing Request as required by Section 2.03. 
 (b) Legal Opinions. The Administrative
Agent (or its counsel) shall have received, on behalf of itself, the Lenders and each Issuing Bank on the Closing Date, (i) a customary written opinion of Weil, Gotshal & Manges LLP, in its capacity as special counsel to the Loan
Parties, (ii) a customary written opinion of Kegler Brown, in its capacity as special Ohio counsel to the Ohio Loan Parties, (iii) a customary written opinion of Norris McLaughlin & Marcus, in its capacity as special New Jersey
counsel to the New Jersey Loan Parties and (iv) and a customary written opinion of K&L Gates, in its capacity as special North Carolina counsel to the North Carolina Loan Parties and
theSouth Florida Loan PartyKinetics, Inc., a Florida corporation, in each
case, dated the Closing Date and addressed to the Administrative Agent, the Lenders and each Issuing Bank. 
 (c) Financial
Statements and Pro Forma Financial Statements. The Administrative Agent shall have received (i) the audited consolidated balance sheet and related audited consolidated statements of income and cash flows of inVentiv Group Holdings or Syneos Health US, Inc. (f/k/a inVentiv Health, Inc.), as applicable, as of and for the fiscal years ended December 31,
2014, December 31, 2015, and December 31, 2016, (ii) the unaudited consolidated balance sheet and related unaudited consolidated statements of income and cash flows of inVentiv Group Holdings as of and for the fiscal quarter
ended March 31, 2017, (iii) the audited consolidated balance sheet and related audited consolidated statements of income or operations and cash flows of INC Holdings as of and for the fiscal years ended December 31,
2014, December 31, 2015, and December 31, 2016, (iv) the unaudited consolidated balance sheet and related unaudited consolidated statements of income or operations and cash flows of INC Holdings as of and for the fiscal quarter
ended March 31, 2017 and (v) a copy of the Proxy Statement (as defined in the Merger Agreement) initially filed with the SEC in connection with the Closing Date Merger. 

(d) Secretary’s Certificate and Good Standing Certificates. The Administrative Agent (or its counsel) shall have received
(i) a certificate of each Loan Party, dated the Closing Date and executed by a secretary, assistant secretary or other Responsible Officer thereof, which shall (A) certify that attached thereto

  
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are (x) a true and complete copy of the certificate or articles of incorporation, formation or organization of such Loan Party certified by the relevant authority of its jurisdiction of
organization, which certificate or articles of incorporation, formation or organization have not been amended (except as attached thereto) since the date reflected thereon, (y) a true and correct copy of the by-laws or operating, management,
partnership or similar agreement of such Loan Party, together with all amendments thereto as of the Closing Date, which by-laws or operating, management, partnership or similar agreement are in full force and effect, and (z) a true and complete
copy of the resolutions or written consent, as applicable, of its board of directors, board of managers, sole member or other applicable governing body authorizing the execution and delivery of the Loan Documents, which resolutions or consent have
not been modified, rescinded or amended (other than as attached thereto) and are in full force and effect, and (B) identify by name and title and bear the signatures of the officers, managers, directors or other authorized signatories of such
Loan Party authorized to sign the Loan Documents to which such Loan Party is a party on the Closing Date and (ii) a good standing (or equivalent) certificate for such Loan Party from the relevant authority of its jurisdiction of organization,
dated as of a recent date. 
 (e) Representations and Warranties. (i) The Specified Merger Agreement Representations shall be
true and correct to the extent required by the terms of the definition thereof and (ii) the Specified Representations shall be true and correct in all material respects on and as of the Closing Date; provided that (A) in the case of any
Specified Representation which expressly relates to a given date or period, such representation and warranty shall be true and correct in all material respects as of the respective date or for the respective period, as the case may be and
(B) if any Specified Representation is qualified by or subject to a “material adverse effect”, “material adverse change” or similar term or qualification, (1) the definition thereof shall be the definition of
“Closing Date Material Adverse Effect” for purposes of the making or deemed making of such Specified Representation on, or as of, the Closing Date (or any date prior thereto) and (2) such Specified Representation shall be true and
correct in all respects. 
 (f) Fees. Prior to or substantially concurrently with the funding of the Initial Term Loans hereunder, the
Administrative Agent shall have received (i) all fees required to be paid by the Administrative Borrower on the Closing Date pursuant to the Fee Lettersthose certain fee letters, dated as of June 14, 2017, by and among, inter alios, the Administrative Borrower, the applicable Arrangers and the Administrative Agent and (ii) all expenses required to be paid by the Borrowers for which invoices have been presented at least three Business Days prior to the Closing Date or such later date to which the Administrative Borrower
may agree (including the reasonable fees and expenses of legal counsel that are payable under the “engagement letter” relating to the credit facilities), in each case on or before the Closing Date, which amounts may be offset against the
proceeds of the Loans. 
 (g) Refinancing. Substantially concurrently with the initial funding of the Loans hereunder,
including by use of the proceeds thereof, the INC Refinancing and the inVentiv Refinancing shall be consummated. 
 (h) [Reserved].

 (i) Solvency. The Administrative Agent shall have received a certificate in substantially the form of Exhibit J from the
chief financial officer (or other officer with reasonably equivalent responsibilities) of the Administrative Borrower dated as of the Closing Date and certifying as to the matters set forth therein. 

(j) Perfection Certificate. The Administrative Agent shall have received a completed Perfection Certificate dated as of the Closing Date
and signed by a Responsible Officer of the Administrative Borrower on behalf of all the Loan Parties, together with all attachments contemplated thereby. 

(k) Pledged Stock and Pledged Notes. Subject to the final paragraph of this Section 4.01, the Administrative Agent (or its
counsel) shall have received (i) the certificate representing any Capital Stock required to be pledged pursuant to the Security Agreement, together with an undated stock power or similar 

  
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 Section 4.03. Conditions
to Delayed Draw Term A Loans. The obligation of each Delayed Draw Term A Lender to honor any request for Credit Extension after
the Amendment No. 2 Closing Date for the Borrowing of Delayed Draw Term A Loans is subject to satisfaction or waiver of the following conditions precedent: 

(a)
The representations and warranties of each Loan Party set forth in Article 3 and in each other Loan Document shall be true and correct in all material respects on and as of the date of such Credit Extension with the same effect as though made on and as of such date, except to the extent
such representations and warranties expressly relate to an earlier date, in which case they shall be true and correct in all material respects as of such earlier date; provided that any representation and warranty that is qualified as to
“materiality,” “Material Adverse Effect” or similar language shall be true and correct in all respects on the date of such Credit Extension or on such earlier date, as the case may be. 

(b) No
Default or Event of Default shall exist or would result from such proposed Credit Extension or from the application of the
proceeds therefrom. 
 (c) The Administrative Borrower shall be in compliance on a Pro Forma Basis (excluding the cash proceeds of such Delayed Draw Term A Loans) with the First Lien Leverage Ratio as of the last day of the most recently ended period of four
consecutive fiscal quarters for which financial statements are available, as set forth in Section 6.13 herein. 

(d) The Administrative Agent shall have received a Request for Credit
Extension in accordance with the requirements hereof and which request for Credit Extension shall have been provided by the
Administrative Borrower to the Administrative Agent not less than three Business Days prior to such Delayed Draw Term A Loan Funding Date. 

Each Credit Extension after the Amendment No. 2 Closing Date shall be deemed
to constitute a representation and warranty by the Administrative Borrower on the date thereof as to the matters specified in paragraphs (a), (b) and (c) of this Section. 

ARTICLE 5 AFFIRMATIVE COVENANTS 

From the Closing Date until the date on which all Commitments have expired or terminated and the principal of and interest on each Loan and
all fees, expenses and other amounts payable under any Loan Document (other than (i) contingent indemnification obligations for which no claim or demand has been made and (ii) Banking Services Obligations or Secured Hedging Obligations as
to which arrangements reasonably satisfactory to the applicable counterparty have been made) have been paid in full in the manner prescribed by Section 2.18 and all Letters of Credit have expired or have been terminated (or have been
(x) collateralized or back-stopped by a letter of credit or otherwise in a manner reasonably satisfactory to the relevant Issuing Bank or (y) deemed reissued under another agreement in a manner reasonably acceptable to the applicable
Issuing Bank and the Administrative Agent) and all LC Disbursements have been reimbursed (such date, the “Termination Date”), the Administrative Borrower hereby covenants and agrees with the Lenders that: 

Section 5.01. Financial Statements and Other Reports. The Administrative Borrower will deliver to the Administrative Agent for
delivery by the Administrative Agent, subject to Section 9.05(f), to each Lender: 
 (a) Quarterly Financial Statements. As soon
as available, and in any event within 45 days after the end of each of the first three Fiscal Quarters of each Fiscal Year, commencing with the Fiscal Quarter ending September 30, 2017, the consolidated balance sheet of the Administrative
Borrower as at the end of such Fiscal Quarter and the related consolidated statements of income or operations and cash flows of the Administrative Borrower for such Fiscal Quarter and for the period from the beginning of the then current Fiscal Year
to the end of such Fiscal Quarter, and, commencing with the financial statements required to be 

  
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 value of the net assets of such Restricted Subsidiary attributable to the Administrative Borrower’s (or
its applicable Restricted Subsidiary’s) equity interest therein as reasonably estimated by the Administrative Borrower (and such designation shall only be permitted to the extent such Investment is otherwise permitted under
Section 6.06). The designation of any Unrestricted Subsidiary as a Restricted Subsidiary shall constitute the making, incurrence or granting, as applicable, at the time of designation of any then-existing Investment, Indebtedness or Lien
of such Restricted Subsidiary, as applicable; provided that upon any re-designation of any Unrestricted Subsidiary as a Restricted Subsidiary, the Administrative Borrower shall be deemed to continue to have an Investment in the resulting
Restricted Subsidiary in an amount (if positive) equal to (i) the Administrative Borrower’s “Investment” in such Restricted Subsidiary at the time of such re-designation, minus (ii) the portion of the fair market
value of the net assets of such Restricted Subsidiary attributable to the Administrative Borrower’s equity therein at the time of such re-designation. As of the Closing Date, the subsidiaries listed on Schedule 5.10 hereto have been
designated as Unrestricted Subsidiaries. 
 Section 5.11. Use of
Proceeds. 

(a)
Section 5.11. Use of Proceeds. The Borrowers shall use the proceeds of (i) the Revolving Loans on and after the Closing Date to finance working capital needs and other general corporate purposes of the
Administrative Borrower and its subsidiaries (including for capital expenditures, acquisitions, Investments, working capital and/or purchase price adjustments (including in connection with the Closing Date Merger), Restricted Payments, Restricted
Debt Payments and related fees and expenses) and any other purpose not prohibited by the terms of the Loan Documents; provided that on the Closing Date, any such Borrowing of Revolving Loans shall not exceed an aggregate principal amount of
$25,000,000 (excluding, for the avoidance of doubt, Letters of Credit). and (ii) the Revolving
Loans on and after the Amendment No. 2 Closing Date to (x) in the case of Replacement Revolving Loans (as defined in Amendment No. 2) only, refinance in full any Revolving Loans outstanding on or immediately prior to the Amendment No. 2 Closing Date
and (y) in the case of Revolving Loans (other than Replacement Revolving Loans), finance working capital needs and other general corporate purposes of the Administrative Borrower and its subsidiaries (including for capital expenditures,
acquisitions, Investments, working capital and/or purchase price adjustments, Restricted Payments, Restricted Debt Payments and related fees and expenses) and any other purpose not prohibited by the terms of the Loan Documents. 
 (b) The Borrowers shall use the proceeds of the (xi) Initial Term Loans made on
the Closing Date, solely to finance a portion of the Transactions (including working capital and/or purchase price adjustments under the Merger Agreement (including with respect to the amount of any Cash, Cash Equivalents, marketable securities and
working capital to be acquired) and the payment of Transaction Costs) and, (yii)(1x) Replacement Term A Loans (as defined in Amendment
No. 1), made on the 2018 Replacement Term A Closing Date, solely to refinance the Initial Term A Loans and (2y) Replacement Term B Loans (as defined in Amendment No. 1), made on the 2018 Replacement Term B Closing Date, solely to refinance
the Initial Term B Loans. Letters of Credit (including the Existing Letters of Credit) may be
issued (i) on the Closing Date to replace or provide credit support for any letter of credit, bank guarantee and/or surety, customs, performance or similar bond of the Administrative Borrower and its subsidiaries or any of their respective
Affiliates and/or to replace cash collateral posted by any of the foregoing Persons and (ii) after the Closing Date, for general corporate purposes of the Administrative Borrower and its subsidiaries and any other purpose not prohibited by the
terms of the Loan Documents.and (iii) Replacement Term A Loans (as defined in Amendment
No. 2), solely to refinance in full the Initial Term A Loans outstanding on or immediately prior to the Amendment No. 2 Closing Date, and (y) Incremental Term A
Loans (as defined in Amendment No. 2) made on the Amendment No. 2 Closing Date, to prepay a portion of the Initial Term B Loans. 

(c) The
Borrowers shall use the proceeds of the Delayed Draw Term A Loans to (i) redeem, repay, defease or discharge in full the Senior
Unsecured Notes and/or (ii) repay a portion of any of the Initial Term B Loans outstanding immediately prior to giving effect to the applicable Delayed Draw Term A Loan Funding Date.

  
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 (d) Letters of Credit (including the Existing Letters of Credit) may be issued (i) on the Closing Date to replace or provide credit support for
any letter of credit, bank guarantee and/or surety, customs, performance or similar bond of the Administrative Borrower and its subsidiaries or any of their respective Affiliates and/or to replace cash collateral posted by any of the foregoing
Persons (for the avoidance of doubt, it being understood and agreed that Letters of Credit that were issued on or after the Closing Date and remain outstanding on the Amendment
No. 2 Closing Date shall be deemed to be Letters of Credit issued under and with respect to the Revolving Credit Commitments established pursuant to the terms of Amendment No.
2) and (ii) after the Closing Date, for general corporate purposes of the Administrative Borrower and its subsidiaries and any other purpose not prohibited by the terms of
the Loan Documents. 
 Section 5.12. Covenant to Guarantee Obligations
and Provide Security. 
 (a) Upon (i) the formation or acquisition after the Closing Date of any Restricted Subsidiary that is a
Domestic Subsidiary, (ii) the designation of any Unrestricted Subsidiary that is a Domestic Subsidiary as a Restricted Subsidiary, (iii) any Restricted Subsidiary that is a Domestic Subsidiary ceasing to be an Immaterial Subsidiary or
(iv) any Restricted Subsidiary that was an Excluded Subsidiary ceasing to be an Excluded Subsidiary, (x) if the event giving rise to the obligation under this Section 5.12(a) occurs during the first three Fiscal Quarters of any
Fiscal Year, on or before the date on which financial statements are required to be delivered pursuant to Section 5.01(a) for the Fiscal Quarter in which the relevant formation, acquisition, designation or cessation occurred or
(y) if the event giving rise to the obligation under this Section 5.12(a) occurs during the fourth Fiscal Quarter of any Fiscal Year, on or before the date that is 60 days after the end of such Fiscal Quarter (or, in the cases of
clauses (x) and (y), such longer period as the Administrative Agent may reasonably agree), the Administrative Borrower shall (A) cause such Restricted Subsidiary to comply with the relevant requirements set forth in the
definition of “Collateral and Guarantee Requirement” (other than clause (h) thereof) and (B) upon the reasonable request of the Administrative Agent, cause the relevant Restricted Subsidiary to deliver to the Administrative Agent a
signed copy of a customary opinion of counsel for such Restricted Subsidiary, addressed to the Administrative Agent and the Lenders; provided, however, that notwithstanding the foregoing, no subsidiary that is an Excluded Subsidiary
shall be required to take any action described in this Section 5.12(a). 
 (b) Within 90 days after the acquisition by any Loan
Party of any Material Real Estate Asset (other than any Excluded Asset) (or such longer period as the Administrative Agent may reasonably agree), the Administrative Borrower shall notify the Administrative Agent (who shall notify the Pro Rata
Lenders), and the Administrative Borrower will cause such Loan Party to take such actions as are required by the Real Estate Collateral Requirements (provided that the actions required under clause (d) of the definition of
“Real Estate Collateral Requirements shall be satisfied within 70 days after the acquisition of the relevant Material Real Estate Assets (or such longer period as the Administrative Agent may reasonably agree)), all at the expense of the
Borrowers; it being understood and agreed that with respect to any Material Real Estate Asset owned by any Restricted Subsidiary at the time such Restricted Subsidiary is required or elects to become a Loan Party under Section 5.12(a) above,
such Material Real Estate Asset shall be deemed to have been acquired by such Restricted Subsidiary on the first day of the time period within which such Restricted Subsidiary is required to become or has elected to become a Loan Party under
Section 5.12(a). Notwithstanding the foregoing, in the event that (x) any Material Real Estate Asset would be required to be mortgaged pursuant to this Section 5.12, and (y) any Pro Rata Lender has notified the
Administrative Agent in writing (who shall notify the Administrative Borrower) during the period commencing from the date on which such Pro Rata Lender receives the Flood Documents and ending no later than eighteen days thereafter that its flood
insurance diligence and compliance has not been completed, the relevant Loan Party shall instead execute and deliver such Mortgage within three Business Days of receipt of written notice from the Administrative Agent (based on the date of notice
from such Pro Rata Lender to the Administrative Agent) that such flood insurance diligence is complete (or such longer time period as agreed by the Administrative Agent in its reasonable discretion); it being understood and agreed that (i) the
Administrative Agent shall promptly deliver the Flood Documents to the Pro Rata Lenders, (ii) any such Pro Rata Lender shall advise the Administrative Agent promptly upon completion of such flood insurance diligence and compliance and
(iii) no delay in the execution by any Loan 

  
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 extension, renewal, restatement or refunding of any Restricted Debt, in each case, that is permitted under
the Loan Documents in respect thereof. 
 Section 6.12. Fiscal Year. The Administrative Borrower shall not change its Fiscal
Year-end to a date other than December 31; provided, that, the Administrative Borrower may, upon written notice to the Administrative Agent, change its Fiscal Year-end to another date, in which case the Administrative Borrower and the
Administrative Agent shall, and are hereby authorized to, make any adjustments to this Agreement that are necessary to reflect such change in Fiscal Year. 

Section 6.13. Financial Covenant. 

(a) First Lien Leverage Ratio. On the last day of any Test Period (it being understood and agreed that this Section 6.13(a)
shall not apply earlier than the last day of the first full Fiscal Quarter ending after the Closing Date), the Administrative Borrower shall not permit the First Lien Leverage Ratio to be greater than (i) for each Test Period ending prior to
March 31, 20192020, 5.0:1.0 or (ii) for
each Test Period ending on or after March 31, 20192020, 4.5:1.0. 
 (b) Financial Cure. Notwithstanding anything to the contrary in this
Agreement (including Article 7), upon the occurrence of an Event of Default as a result of the Administrative Borrower’s failure to comply with Section 6.13(a) above for any Fiscal Quarter, the Administrative Borrower shall
have the right (the “Cure Right”) (at any time during such Fiscal Quarter or thereafter until the date that is 15 Business Days after the date on which financial statements for such Fiscal Quarter are required to be delivered
pursuant to Section 5.01(a) or (b), as applicable (such 15 Business Day period, the “Cure Period”)) to issue Qualified Capital Stock or other equity (such other equity to be on terms reasonably acceptable to the
Administrative Agent) for Cash or otherwise receive Cash contributions in respect of its Qualified Capital Stock (the “Cure Amount”), and thereupon the Administrative Borrower’s compliance with Section 6.13(a) shall
be recalculated giving effect to a pro forma increase in the amount of Consolidated Adjusted EBITDA by an amount equal to the Cure Amount (notwithstanding the absence of a related addback in the definition of “Consolidated Adjusted
EBITDA”) solely for the purpose of determining compliance with Section 6.13(a) as of the end of such Fiscal Quarter and for applicable subsequent periods that include such Fiscal Quarter. If, after giving effect to the foregoing
recalculation (but not, for the avoidance of doubt, taking into account any immediate repayment of Indebtedness in connection therewith), the requirements of Section 6.13(a) would be satisfied, then the requirements of
Section 6.13(a) shall be deemed satisfied as of the end of the relevant Fiscal Quarter with the same effect as though there had been no failure to comply therewith at such date, and the applicable breach or default of
Section 6.13(a) that had occurred (or would have occurred) shall be deemed cured for the purposes of this Agreement. Notwithstanding anything herein to the contrary, (i) in each four consecutive Fiscal Quarter period there shall be
at least two Fiscal Quarters (which may, but are not required to be, consecutive) in which the Cure Right is not exercised, (ii) during the term of this Agreement, the Cure Right shall not be exercised more than five times, (iii) the Cure
Amount shall be no greater than the amount required for the purpose of complying with Section 6.13(a), (iv) there shall be no pro forma or other reduction of the amount of Indebtedness by the amount of any Cure Amount for purposes
of determining compliance with Section 6.13(a) for the Fiscal Quarter in respect of which the Cure Right was exercised (other than, with respect to any future period, to the extent of any portion of such Cure Amount that is actually
applied to repay Indebtedness) and (v) during any Test Period in which any Cure Amount is included in the calculation of Consolidated Adjusted EBITDA as a result of any exercise of the Cure Right, such Cure Amount shall be disregarded for
purposes of determining (A) whether any financial ratio-based condition to the availability of any carve-out set forth in Article 6 of this Agreement has been satisfied or (B) the Applicable Rate or the Commitment Fee Rate. 

(c) It is understood and agreed that the covenant described in this Section 6.13 shall only apply to the Initial Revolving Facility
and the Initial Term A Loan Facility. 

  
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 (i) Employee Benefit Plans. The occurrence of one or more ERISA Events, which
individually or in the aggregate result in liability of the Administrative Borrower or any of its Restricted Subsidiaries in an aggregate amount that would reasonably be expected to result in a Material Adverse Effect; or 

(j) Change of Control. The occurrence of a Change of Control; or 

(k) Guaranties, Collateral Documents and Other Loan Documents. At any time after the execution and delivery thereof, (i) any
material Loan Guaranty for any reason, other than the occurrence of the Termination Date, shall cease to be in full force and effect (other than in accordance with its terms) or is declared to be null and void or any Loan Guarantor shall repudiate
in writing its obligations thereunder (other than as a result of the discharge of such Loan Guarantor in accordance with the terms thereof), (ii) this Agreement or any material Collateral Document ceases to be in full force and effect or shall
be declared null and void or any Lien on Collateral created under any Collateral Document ceases to be perfected with respect to a material portion of the Collateral (other than solely by reason of (w) such perfection not being required
pursuant to this Agreement or any other Loan Document, (x) the failure of the Administrative Agent to maintain possession of any Collateral actually delivered to it or the failure of the Administrative Agent to file UCC (or equivalent)
continuation statements, (y) a release of Collateral in accordance with the terms hereof or thereof or (z) the occurrence of the Termination Date or any other termination of such Collateral Document in accordance with the terms thereof) or
(iii) other than in any bona fide, good faith dispute as to the scope of Collateral or whether any Lien has been, or is required to be released, any Loan Party shall contest in writing the validity or enforceability of any material provision of
any Loan Document (or any Lien purported to be created by the Collateral Documents or any Loan Guaranty) or denies in writing that it has any further liability (other than by reason of the occurrence of the Termination Date or the termination of any
other Loan Document in accordance with the terms thereof), including with respect to future advances by the Lenders, under any Loan Document to which it is a party; it being understood and agreed that the failure of the Administrative Agent to
maintain possession of any Collateral actually delivered to it or file any UCC (or equivalent) continuation statement shall not result in an Event of Default under this clause (k) or any other provision of any Loan Document; or 

(l) Subordination. The Obligations ceasing or the assertion in writing by any Loan Party that the Obligations cease to constitute senior
indebtedness under the subordination provisions of any document or instrument evidencing any Restricted Debt in excess of the Threshold Amount or any such subordination provision being invalidated or otherwise ceasing, for any reason, to be valid,
binding and enforceable obligations of the parties thereto; 
 then, and in every such event (other than (x) an event with respect to any Borrower
described in clause (f) or (g) of this Article or (y) any Event of Default arising under Section 6.13(a)), and at any time thereafter during the continuance of such event, the Administrative Agent may, and at the
request of the Required Lenders shall, by notice to the Administrative Borrower, take any of the following actions, at the same or different times: (i) terminate the Revolving Credit Commitments and the Delayed Draw Term A Commitment (to the extent, and thereupon such Revolving Credit Commitments and Delayed Draw Term A Commitments shall terminate immediately, (ii) declare the Loans then outstanding to be due and
payable in whole (or in part, in which case any principal not so declared to be due and payable may thereafter be declared to be due and payable), and thereupon the principal of the Loans so declared to be due and payable, together with accrued
interest thereon and all fees and other obligations of the Borrowers accrued hereunder, shall become due and payable immediately, without presentment, demand, protest or other notice of any kind, all of which are hereby waived by the Borrowers and
(iii) require that the Borrowers deposit in the LC Collateral Account an additional amount in Cash as reasonably requested by the Issuing Banks (not to exceed 102% of the relevant face amount of the then outstanding LC Exposure (minus
the amount then on deposit in the LC Collateral Account)); provided that (A) upon the occurrence of an event with respect to the Administrative Borrower described in clauses (f) or (g) of this Article, any such
Commitments shall automatically terminate and the principal of the Loans then outstanding, together with accrued interest thereon and all fees and other obligations of the Borrowers accrued hereunder, shall automatically become due and payable,
without presentment, demand, 

  
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 protest or other notice of any kind, all of which are hereby waived by the Borrowers, and the obligation of
the Borrowers to Cash collateralize the outstanding Letters of Credit as aforesaid shall automatically become effective, in each case without further action of the Administrative Agent or any Lender and (B) during the continuance of any Event
of Default arising under Section 6.13(a), (X) solely upon the request of the Required Revolving Lenders (but not the Required Lenders or any other Lender or group of Lenders), the Administrative Agent shall, by notice to the Administrative
Borrower, (1) terminate the Revolving Credit Commitments and the Delayed Draw Term A Commitments, and thereupon such Revolving
Commitments and Delayed Draw Term A Commitments shall terminate immediately, (2) declare the Revolving Loans then
outstanding to be due and payable in whole (or in part, in which case any principal not so declared to be due and payable may thereafter be declared to be due and payable), and thereupon the principal of the Revolving Loans so declared to be due and
payable, together with accrued interest thereon and all fees and other obligations of the Borrowers accrued hereunder, shall become due and payable immediately, without presentment, demand, protest or other notice of any kind, all of which are
hereby waived by the Borrowers and (3) require that the Borrowers deposit in the LC Collateral Account an additional amount in Cash as reasonably requested by the Issuing Banks (not to exceed 102% of the relevant face amount of the then outstanding
LC Exposure (minus the amount then on deposit in the LC Collateral Account)), (Y) solely at the request of the Required Term A Lenders, declare the Initial Term A Loans then outstanding to be due and payable in whole (or in part, in which case
any principal not so declared to be due and payable may thereafter be declared to be due and payable), and thereupon the principal of the Initial Term A Loans so declared to be due and payable, together with accrued interest thereon and all fees and
other obligations of the Borrowers accrued hereunder, shall become due and payable immediately, without presentment, demand, protest or other notice of any kind, all of which are hereby waived by each Borrower and (Z) subject to the Financial
Covenant Standstill, the Administrative Agent may, and at the request of the Required Term B Lenders shall, by notice to the Administrative Borrower, declare the Loans (other than the Initial Term A Loans and the Revolving Loans) then outstanding to
be due and payable in whole (or in part, in which case any principal not so declared to be due and payable may thereafter be declared to be due and payable), and thereupon the principal of the Loans so declared to be due and payable, together with
accrued interest thereon and all fees and other obligations of the Borrowers accrued hereunder, shall become due and payable immediately, without presentment, demand, protest or other notice of any kind, all of which are hereby waived by the
Borrowers. Upon the occurrence and during the continuance of an Event of Default, the Administrative Agent may, and at the request of the Required Lenders shall, exercise any rights and remedies provided to the Administrative Agent under the Loan
Documents or at law or equity, including all remedies provided under the UCC. 
 ARTICLE 8 THE ADMINISTRATIVE AGENT 

Each of the Lenders and the Issuing Banks, each, on behalf of itself and its applicable Affiliates and in their respective capacities as such
and as Hedge Banks and/or Cash Management Banks, as applicable, hereby irrevocably appoints Credit
SuisseJPMorgan Chase Bank, N.A. (or any successor appointed pursuant hereto) as Administrative Agent and authorizes the
Administrative Agent to take such actions on its behalf, including execution of the other Loan Documents, and to exercise such powers as are delegated to the Administrative Agent by the terms of the Loan Documents, together with such actions and
powers as are reasonably incidental thereto. 
 Any Person serving as Administrative Agent hereunder shall have the same rights and
powers in its capacity as a Lender as any other Lender and may exercise the same as though it were not the Administrative Agent, and the term “Lender” or “Lenders” shall, unless otherwise expressly indicated, unless the context
otherwise requires or unless such Person is in fact not a Lender, include each Person serving as Administrative Agent hereunder in its individual capacity. Such Person and its Affiliates may accept deposits from, lend money to, own securities of,
act as the financial advisor or in any other advisory capacity for and generally engage in any kind of business with any Loan Party or any subsidiary of any Loan Party or other Affiliate thereof as if it were not the Administrative Agent hereunder.
The Lenders acknowledge that, pursuant to such activities, the Administrative Agent or its Affiliates may receive information regarding any Loan Party or any of its Affiliates (including information that may be subject to confidentiality obligations
in favor of such Loan 

  
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 be in writing and shall be delivered by hand or overnight courier service, mailed by certified or registered
mail or sent by facsimile or email, as follows: 
 (i) if to any Loan Party, to such Loan Party in the care of the
Administrative Borrower at: 
 INC Research HoldingsSyneos Health, Inc.  

1030 Sync Street 

Morrisville, North Carolina 27560  
 3201 Beechleaf Court, Suite 600 

Raleigh, NC 27604

 Attention: Jason Meggs, Chief Financial Officer 
 Email:
gregory.rush@incresearchjason.meggs@syneoshealth.com

 Facsimile: (919)-334-3651 

with a copy to (which shall not constitute notice to any Loan Party): 

Sullivan & CromwellLatham & Watkins LLP  

125 Broad Street885 Third Avenue 
 New
York, NY 1000410022-24984943 

Attention: Neal McKnightKeith Halverstam, Gene Mazzaro and Nicole Fanjul 

Email: keith.halverstam@lw.com; eugene.mazzaro@lw.com and 
 nicole.fanjul@lw.com 
 Email:
mcknight@sullcrom.com 
 Facsimile: (212) 291-9097 

Weil, Gotshal & Manges LLP 
 200 Crescent Court, Suite
300 

Dallas, TX 75201

 Attention: Courtney Marcus 
 Email:
courtney.marcus@weil.com  
 Facsimile: (214212) 746751-77774864 

(ii) if to the Administrative Agent, to the address, facsimile number, electronic mail address or telephone number specified
on Schedule 1.01(d); 
 (iii) if to any Issuing Bank, to the
applicable Issuing Bank at: 
 Credit Suisse AG, Cayman Islands Branch 

Eleven Madison Avenue, 9th Floor 
 New York, NY
10010  

JPMorgan Chase Bank, N.A.

 Address: 10 South Dearborn St., Chicago, IL, 60603 
 Attention: LC Agency
Team 
 Email:
Chicago.LC.Agency.Activity.Team@JPMChase.com 
 Telephone: 855-609-0059 

Facsimile: 214-307-6874

 Wells Fargo Bank, N.A. 
 Address: 794 Davis Street, 2nd Floor, San Leandro, California, 94577 
 Attention: U. S. Trade Finance Services Department - Standby Letters of Credit  
 Email:
list.ib-lettersofcredit-ny@credit-suisseStandbyLC@wellsfargo.com 

  
 179 

 Telephone:
(212) 325-5397800-798-2815 

Facsimile: 704-715-0205

 PNC Bank, N.A.

 Address: 500 First Ave, Pittsburgh, PA 15218 
 Attention: International Trade
Product Deliver 

Email: INTERNATIONALCLIENTCARE@PNC.COM 
 Telephone:
800-682-4689 

Facsimile: 412-762-6118

 Bank of America, N.A. 
 Address: 1 Fleet Way, Scranton PA
18507 
 Attention:
Standby Dept. 

Email: scranton_standby_lc@bankofamerica.com 
 Telephone: 1
800-370-7519 

Facsimile: 1 800-755-8743

 ING Capital LLC

 Address: 1133 Avenue of Americas, New York, NY 10036 
 Attention: Mark
LaGreca 
 Email:
DL-NYCLCSupport@ING.COM 
 Telephone: 646-424-8234 

Facsimile: (212) 325-8315646-424-8936 
 or 

such address as may be specified in the documentation pursuant to which such 

Issuing Bank is appointed in its capacity as such, and 

(iv) if to any Lender, to it at its address or facsimile number or email address set forth in its Administrative
Questionnaire. 
 All such notices and other communications (A) sent by hand or overnight courier service, or mailed by certified or registered mail,
shall be deemed to have been given when delivered in person or by courier service and signed for against receipt thereof or three Business Days after dispatch if sent by certified or registered mail, in each case, delivered, sent or mailed (properly
addressed) to the relevant party as provided in this Section 9.01 or in accordance with the latest unrevoked direction from such party given in accordance with this Section 9.01 or (B) sent by facsimile shall be deemed
to have been given when sent and when receipt has been confirmed by telephone; provided that notices and other communications sent by telecopier shall be deemed to have been given when sent (except that, if not given during normal business
hours for the recipient, such notices or other communications shall be deemed to have been given at the opening of business on the next Business Day for the recipient). Notices and other communications delivered through electronic communications to
the extent provided in clause (b) below shall be effective as provided in such clause (b). 
 (b) Notices and other
communications to the Lenders hereunder may be delivered or furnished by electronic communications (including e-mail and Internet or Intranet websites) pursuant to procedures set forth herein or otherwise approved by the Administrative Agent. The
Administrative Agent or the Administrative Borrower (on behalf of any Loan Party) may, in its discretion, agree to accept notices and other communications to it hereunder by electronic communications pursuant to procedures set forth herein or
otherwise approved by it; provided that approval of such procedures may be limited to particular notices or communications. All such notices and other communications (i) sent to an e-mail address shall be deemed received upon the
sender’s receipt of an acknowledgement from the intended recipient (such as by the “return receipt requested” function, as available, return e-mail or other written acknowledgement); provided that any 

  
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 (iv) the Administrative Agent and the Administrative Borrower may amend,
restate, amend and restate or otherwise modify the Intercreditor Agreements, any Intercreditor Agreement and/or any other Additional Agreement as provided therein, 

(v) the Administrative Agent may amend the Commitment Schedule to reflect assignments entered into pursuant to
Section 9.05, Commitment reductions or terminations pursuant to Section 2.09, implementations of Additional Commitments or incurrences of Additional Loans pursuant to Sections 2.22, 2.23 and/or 9.02(c)
and reductions or terminations of any such Additional Commitments or Additional Loans, 
 (vi) no Defaulting Lender shall
have any right to approve or disapprove any amendment, waiver or consent hereunder, except as permitted pursuant to Section 2.21(b) and except that the Commitment and any Additional Commitment of any Defaulting Lender may not be
increased without the consent of such Defaulting Lender (it being understood that any Commitment or Loan held or deemed held by any Defaulting Lender shall be excluded from any vote hereunder that requires the consent of any Lender, except as
expressly provided in Section 2.21(b)), 
 (vii) this Agreement may be amended (or amended and restated) with the
written consent of the Required Lenders, the Administrative Agent and the Administrative Borrower (i) to add one or more additional credit facilities to this Agreement and to permit any extension of credit from time to time outstanding
thereunder and the accrued interest and fees in respect thereof to share ratably in the relevant benefits of this Agreement and the other Loan Documents and (ii) to include appropriately the Lenders holding such credit facilities in any
determination of the Required Lenders on substantially the same basis as the Lenders prior to such inclusion, and 
 (viii)
any amendment, waiver or modification of any term or provision that directly affects Lenders under one or more Classes and does not directly affect Lenders under one or more other Classes may be effected with the consent of Lenders owning 50% of the
aggregate commitments or Loans of such directly affected Class in lieu of the consent of the Required Lenders. 
 (e) Notwithstanding the foregoing, only the consent of the Delayed Draw Term A Lenders holding a majority of the outstanding Delayed
Draw Term A Commitments shall be necessary to amend, modify or waive any condition precedent set forth Section 4.03. 

Section 9.03. Expenses; Indemnity. 

(a) Subject to Section 9.05(f), the Borrowers shall pay (i) if the Closing Date occurs, all reasonable and documented out-of-pocket
expenses incurred by each Arranger, the Administrative Agent and their respective Affiliates (but limited, in the case of legal fees and expenses, to the actual reasonable and documented out-of-pocket fees, disbursements and other charges of one
firm of outside counsel to all such Persons taken as a whole, and, if reasonably necessary, of one local counsel in any relevant jurisdiction to all such Persons, taken as a whole) in connection with the syndication and distribution (including via
the Internet or through a service such as IntraLinks) of the Credit Facilities, in connection with the preparation, execution, delivery and administration of the Loan Documents and any related documentation, including in connection with any
amendment, modification or waiver of any provision of any Loan Document (whether or not the transactions contemplated thereby are consummated, but only to the extent the preparation of any such amendment, modification or waiver was requested by the
Administrative Borrower and except as otherwise provided in a separate writing between the Administrative Borrower, the relevant Arranger and/or the Administrative Agent) and (ii) all reasonable and documented out-of-pocket expenses incurred by
the Administrative Agent, the Arrangers, the Issuing Banks or the Lenders or any of their respective Affiliates (but limited, in the case of legal fees and expenses, to the actual reasonable and documented out-of-pocket fees, disbursements and other
charges of one firm of outside counsel to all such Persons taken as a whole and, if necessary, of one local counsel in any relevant jurisdiction to all such Persons, taken as a whole) in connection 

  
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 unconditional release of such Indemnitee from all liability or claims that are the subject matter of such
proceeding and (ii) such settlement does not include any statement as to any admission of fault or culpability. 
 Section 9.04.
Waiver of Claim. To the extent permitted by applicable Requirements of Law, no party to this Agreement nor any Secured Party shall assert, and each hereby waives, any claim against any other party hereto, any Loan Party and/or any Related
Party of any thereof, on any theory of liability, for special, indirect, consequential or punitive damages (as opposed to direct or actual damages) arising out of, in connection with, or as a result of, this Agreement or any agreement or instrument
contemplated hereby, the Transactions, any Loan or any Letter of Credit or the use of the proceeds thereof, except, in the case of any claim by any Indemnitee against the Administrative Borrower, to the extent such damages would otherwise be subject
to indemnification pursuant to the terms of Section 9.03. 
 Section 9.05. Successors and Assigns. 

(a) The provisions of this Agreement shall be binding upon and inure to the benefit of the parties hereto and their respective successors and
permitted assigns; provided that (i) except in a transaction permitted under Section 6.07, the Borrowers may not assign or otherwise transfer any of their rights or obligations hereunder without the prior written consent of
each Lender (and any attempted assignment or transfer by the Borrowers without such consent shall be null and void) and (ii) no Lender may assign or otherwise transfer its rights or obligations hereunder except in accordance with the terms of
this Section 9.05 (any attempted assignment or transfer not complying with the terms of this Section 9.05 shall be null and void). Nothing in this Agreement, expressed or implied, shall be construed to confer upon any Person
(other than the parties hereto, their respective successors and permitted assigns, to the extent provided in paragraph (c) of this Section 9.05, Participants and, to the extent expressly contemplated hereby, the Related
Parties of each of the Arrangers, the Administrative Agent, the Issuing Banks and the Lenders) any legal or equitable right, remedy or claim under or by reason of this Agreement. 

(b) (i) Subject to the conditions set forth in paragraph (b)(ii) below, any Lender may assign to one or more Eligible Assignees all or a
portion of its rights and obligations under this Agreement (including all or a portion of any Additional Loan or Additional Commitment added pursuant to Sections 2.22, 2.23 and/or 9.02(c) at the time owing to it) with the prior
written consent of: 
 (A) the Administrative Borrower (such consent not to be unreasonably withheld, conditioned or
delayed); provided, that (x) the Administrative Borrower shall be deemed to have consented to any assignment of Term B Loans unless it has objected thereto by written notice to the Administrative Agent within 157 Business Days after receipt of written notice thereof
and (y) the consent of the Administrative Borrower shall not be required for any assignment (1) of Term Loans or Term Commitments to any Term Lender or any Affiliate of any Term Lender or an Approved Fund, (2) of any Revolving Loan or
Revolving Commitment to any Revolving Lender, (3) of any Revolving Loan or Revolving Commitment between Goldman Sachs Bank (USA) and Goldman Sachs Lending Partners LLC for so long as either Person remains a Revolving Lender or (4) at any
time when an Event of Default under Section 7.01(a) or Sections 7.01(f) or (g) (with respect to any Borrower) exists; provided, further that the Administrative Borrower may withhold its consent to any
assignment to any Person (other than a Bona Fide Debt Fund) that is not a Disqualified Institution but is known by the Administrative Borrower to be an Affiliate of a Disqualified Institution regardless of whether such Person is identifiable as an
Affiliate of a Disqualified Institution on the basis of such Affiliate’s name; 
 (B) the Administrative Agent
(such consent not to be unreasonably withheld or delayed); provided that no consent of the Administrative Agent shall be required for any assignment to another Lender, any Affiliate of a Lender or any Approved Fund; and 

  
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 (C) in the case of any Revolving Facility unless the relevant assignment is
to a Revolving Lender or an affiliate of a Revolving Lender, each Issuing Bank, not to be unreasonably withheld, conditioned or delayed. 
 (ii) Assignments
shall be subject to the following additional conditions: 
 (A) except in the case of any assignment to another Lender, any
Affiliate of any Lender or any Approved Fund or any assignment of the entire remaining amount of the relevant assigning Lender’s Loans or Commitments of any Class, the principal amount of Loans or Commitments of the assigning Lender subject to
the relevant assignment (determined as of the date on which the Assignment Agreement with respect to such assignment is delivered to the Administrative Agent and determined on an aggregate basis in the event of concurrent assignments to Related
Funds or by Related Funds) shall not be less than (x) $1,000,000500,000, in the case of Term Loans and Term Commitments and (y) $5,000,000 in the case of Revolving Loans and Revolving Credit Commitments, unless the Administrative Borrower and the Administrative Agent otherwise
consent; 
 (B) any partial assignment shall be made as an assignment of a proportionate part of all the relevant
assigning Lender’s rights and obligations under this Agreement; 
 (C) the parties to each assignment shall execute and
deliver to the Administrative Agent an Assignment Agreement via an electronic settlement system acceptable to the Administrative Agent (or, if previously agreed with the Administrative Agent, manually), and shall pay to the Administrative Agent a
processing and recordation fee of $3,500 (which fee may be waived or reduced in the sole discretion of the Administrative Agent); and 

(D) the relevant Eligible Assignee, if it is not a Lender, shall deliver on or prior to the effective date of such assignment,
to the Administrative Agent (1) an Administrative Questionnaire and (2) any IRS form required under Section 2.17. 

(iii) Subject to the acceptance and recording thereof pursuant to paragraph (b)(iv) of this Section 9.05,
from and after the effective date specified in any Assignment Agreement, the Eligible Assignee thereunder shall be a party hereto and, to the extent of the interest assigned pursuant to such Assignment Agreement, have the rights and obligations of a
Lender under this Agreement, and the assigning Lender thereunder shall, to the extent of the interest assigned by such Assignment Agreement, be released from its obligations under this Agreement (and, in the case of an Assignment Agreement covering
all of the assigning Lender’s rights and obligations under this Agreement, such Lender shall cease to be a party hereto but shall continue to be (A) entitled to the benefits of Sections 2.15, 2.16, 2.17 and 9.03
with respect to facts and circumstances occurring on or prior to the effective date of such assignment and (B) subject to its obligations thereunder and under Section 9.13). If any assignment by any Lender holding any Promissory
Note is made after the issuance of such Promissory Note, the assigning Lender shall, upon the effectiveness of such assignment or as promptly thereafter as practicable, surrender such Promissory Note to the Administrative Agent for cancellation,
and, following such cancellation, if requested by either the assignee or the assigning Lender, the Borrowers shall issue and deliver a new Promissory Note to such assignee and/or to such assigning Lender, with appropriate insertions, to reflect the
new commitments and/or outstanding Loans of the assignee and/or the assigning Lender. 
 (iv) The Administrative Agent,
acting for this purpose as an agent of the Borrowers, shall maintain at one of its offices a copy of each Assignment Agreement delivered to it and a register for the recordation of the names and addresses of the Lenders and their respective
successors and assigns, and the commitment of, and principal amount and currency of and interest on the Loans and LC 

  
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 Disbursements owing to, each Lender or Issuing Bank pursuant to the terms hereof from time
to time (the “Register”). Failure to make any such recordation, or any error in such recordation, shall not affect the Administrative Borrower’s obligations in respect of the Loans and LC Disbursements. The entries in the
Register shall be conclusive, absent manifest error, and the Borrowers, the Administrative Agent, the Issuing Banks and the Lenders shall treat each Person whose name is recorded in the Register pursuant to the terms hereof as a Lender hereunder for
all purposes of this Agreement, notwithstanding notice to the contrary. The Register shall be available for inspection by the Administrative Borrower, each Issuing Bank and each Lender (but only as to its own holdings), at any reasonable time and
from time to time upon reasonable prior notice. 
 (v) Upon its receipt of a duly completed Assignment Agreement executed by
an assigning Lender and an Eligible Assignee, the Eligible Assignee’s completed Administrative Questionnaire and any tax certification required by Section 9.05(b)(ii)(D)(2) (unless the assignee is already a Lender hereunder), the
processing and recordation fee referred to in paragraph (b) of this Section 9.05, if applicable, and any written consent to the relevant assignment required by paragraph (b) of this Section 9.05, the
Administrative Agent shall promptly accept such Assignment Agreement and record the information contained therein in the Register. No assignment shall be effective for purposes of this Agreement unless it has been recorded in the Register as
provided in paragraph (b) of this Section 9.05. 
 (vi) By executing and delivering an Assignment Agreement,
the assigning Lender and the Eligible Assignee thereunder shall be deemed to confirm and agree with each other and the other parties hereto as follows: (A) the assigning Lender warrants that it is the legal and beneficial owner of the interest
being assigned thereby free and clear of any adverse claim and that the amount of its commitments, and the outstanding balances of its Loans, in each case without giving effect to any assignment thereof which has not become effective, are as set
forth in such Assignment Agreement, (B) except as set forth in clause (A) above, the assigning Lender makes no representation or warranty and assumes no responsibility with respect to any statement, warranty or representation made in or
in connection with this Agreement, or the execution, legality, validity, enforceability, genuineness, sufficiency or value of this Agreement, any other Loan Document or any other instrument or document furnished pursuant hereto, or the financial
condition of the Administrative Borrower or any Restricted Subsidiary or the performance or observance by the Administrative Borrower or any Restricted Subsidiary of any of its obligations under this Agreement, any other Loan Document or any other
instrument or document furnished pursuant hereto; (C) the assignee represents and warrants that it is not a Disqualified Institution and that it is an Eligible Assignee, legally authorized to enter into such Assignment Agreement; (D) the
assignee confirms that it has received a copy of this Agreement and any Intercreditor Agreement, together with copies of the financial statements referred to in Section 4.01(c) or the most recent financial statements delivered pursuant
to Section 5.01, as applicable, and such other documents and information as it has deemed appropriate to make its own credit analysis and decision to enter into such Assignment Agreement; (E) the assignee will independently and
without reliance upon the Administrative Agent, the assigning Lender or any other Lender and based on such documents and information as it deems appropriate at the time, continue to make its own credit decisions in taking or not taking action under
this Agreement; (F) the assignee appoints and authorizes the Administrative Agent to take such action as agent on its behalf and to exercise such powers under this Agreement as are delegated to the Administrative Agent, by the terms hereof,
together with such powers as are reasonably incidental thereto; and (G) the assignee agrees that it will perform in accordance with their terms all the obligations which by the terms of this Agreement are required to be performed by it as a
Lender. 
 (c) (i) Any Lender may, without the consent of the Borrowers
(except as provided in clause (D)
of the proviso below), the Administrative Agent, any Issuing Bank or any other Lender, sell participations to any bank
or other entity (other than to any Disqualified Institution, any natural Person or, other than with respect to any participation to any Debt Fund Affiliate (any such participations to a Debt Fund Affiliate being

  
 192 

 
subject to the limitation set forth in the first proviso of the last paragraph set forth in Section 9.05(f), as if the limitation
applied to such participations), the Borrowers or any of their Affiliates) (a “Participant”) in all or a portion of such Lender’s rights and obligations under this Agreement (including all or a portion of its commitments and the Loans
owing to it); provided that (A) such Lender’s obligations under this Agreement shall remain unchanged, (B) such Lender shall remain solely responsible to the other parties hereto for the performance of such obligations, and
(C) the Borrowers, the Administrative Agent, the Issuing Banks and the other Lenders shall continue to deal solely and directly with such Lender in connection with such Lender’s rights
and obligations under this Agreement and (D) the consent of the Administrative Borrower (such consent not to be unreasonably withheld, conditioned or delayed) shall be required for any participation of any Revolving Loan and/or Revolving Commitment;
provided, further that the consent of the Administrative Borrower shall not be required for any participation (1) of any Revolving Loan or Revolving Commitment to any Revolving Lender or
(2) at any time when an Event of Default under Sections 7.01(a) or Sections 7.01(f) or (g) (with respect to any Borrower) exists. Any agreement or instrument pursuant to which any Lender sells such a participation shall provide that such Lender shall retain the sole right to enforce this Agreement and to approve any amendment, modification
or waiver of any provision of this Agreement; provided that such agreement or instrument may provide that such Lender will not, without the consent of the relevant Participant, agree to any amendment, modification or waiver described
in (x) clause (A) of the first proviso to Section 9.02(b) that directly and adversely affects the Loans or commitments in which such Participant has an interest and (y) clauses (B)(1), (2) or
(3) of the first proviso to Section 9.02(b). Subject to paragraph (c)(ii) of this Section, the Borrowers agree that each Participant shall be entitled to the benefits of Sections 2.15, 2.16 and
2.17 (subject to the limitations and requirements of such Sections and Section 2.19) to the same extent as if it were a Lender and had acquired its interest by assignment pursuant to paragraph (b) of this Section (it
being understood that the documentation required under Section 2.17(f) is delivered to the participating Lender, and if additional amounts are required to be paid pursuant to Section 2.17(a) or Section 2.17(c), to
the Borrowers and the Administrative Agent). To the extent permitted by applicable Requirements of Law, each Participant also shall be entitled to the benefits of Section 9.09 as though it were a Lender; provided that such Participant
shall be subject to Section 2.18(c) as though it were a Lender. 

(ii) No Participant shall be entitled to receive any greater payment under Section 2.15, 2.16 or 2.17
than the participating Lender would have been entitled to receive with respect to the participation sold to such Participant, unless the sale of the participation to such Participant is made with the Administrative Borrower’s prior written
consent expressly acknowledging that such Participant’s entitlement to benefits under Sections 2.15, 2.16 and 2.17 is not limited to what the participating Lender would have been entitled to receive absent the
participation. 
 (d) Each Lender that sells a participation shall, acting solely for this purpose as a non-fiduciary agent of the
Borrowers, maintain a register on which it enters the name and address of each Participant and its respective successors and registered assigns, and the principal and interest amounts of each Participant’s interest in the Loans or other
obligations under the Loan Documents (a “Participant Register”); provided that no Lender shall have any obligation to disclose all or any portion of any Participant Register (including the identity of any Participant or any
information relating to any Participant’s interest in any Commitment, Loan, Letter of Credit or any other obligation under any Loan Document) to any Person except to the extent that such disclosure is necessary to establish that such
Commitment, Loan, Letter of Credit or other obligation is in registered form under Section 5f.103-1(c) or Proposed Section 1.163-5(b) of the U.S. Treasury Regulations (or the amended or successor version). The entries in the
Participant Register shall be conclusive absent manifest error, and each Lender shall treat each Person whose name is recorded in the Participant Register as the owner of such participation for all purposes of this Agreement notwithstanding any
notice to the contrary. For the avoidance of doubt, the Administrative Agent (in its capacity as Administrative Agent) shall have no responsibility for maintaining a Participant Register. 

(e) (i) Any
Lender may at any time pledge or assign a security interest in all or any portion of its rights under this Agreement (other than to any Disqualified Institution or any natural person) to secure obligations of such Lender, including any pledge or
assignment to secure obligations to any Federal Reserve 

  
 193 

 Bank or other central bank having jurisdiction over such Lender, and this Section 9.05 shall not
apply to any such pledge or assignment of a security interest; provided that no such pledge or assignment of a security interest shall release any Lender from any of its obligations hereunder or substitute any such pledgee or assignee for
such Lender as a party hereto. 
 (ii) No Lender, acting in its capacity as a Lender (or any
Affiliate or other Person acting on such Lender’s behalf) may at any time enter into a total return swap, total rate of return swap, credit default swap or other derivative instrument under which any Secured Obligation is the sole reference
obligation (or a reference obligation constituting at least 25% of the weight in any bucket of such derivative instruments) (any such swap or other derivative instrument, an “Obligations Derivative Instrument”)
if: 
 (A) in respect of a total return
swap or total rate of return swap, such Obligations Derivative Instrument is with any Disqualified Institution and the Lender (or any of its Affiliates or any other Person acting on such Lender’s behalf) has acted as the total return payor (or
similar role however defined in such Obligation Derivative Instrument); or 

(B) in respect of a credit default swap, any Disqualified
Institution has acted as the protection seller (or similar role however defined in such Obligation Derivative Instrument). 

provided, notwithstanding anything contained in the foregoing to the
contrary, nothing in this clause shall prohibit the activities of a Lender (or any Affiliate or other Person acting on such Lender’s behalf) that occur on the public side of an information barrier unless (1) such Person is entering into
such Obligation Derivative Instrument for the purpose of synthetically transferring, in whole or in part, any Secured Obligation held by a Lender which is acting in its capacity as a Lender or on behalf of an entity which is acting in its capacity
as Lender, (2) such Person is not acting as a market-maker in connection with entering into such Obligation Derivative Instrument and (3) the list of Disqualified Institutions and the restrictions relating thereto under this Agreement are
available to such Lender; and provided further that, (x) notwithstanding the foregoing, in no event shall Confidential Information be shared with any counterparty to an Obligations Derivatives Instrument that is a
Disqualified Institution and each Lender shall be required to comply with the relevant confidentiality provisions in connection with any transaction involving Obligations Derivative Instruments and (y) in the event of any Obligations Derivative
Instrument in violation of the foregoing, the Administrative Borrower has the right
to require the unwind of the applicable Obligations Derivative Instrument at the sole cost and expense of the applicable Lender. 

(f) Notwithstanding anything to the contrary contained herein, any Lender (a “Granting Lender”) may
grant to a special purpose funding vehicle (an “SPC”), identified as such in writing from time to time by the Granting Lender to the Administrative Agent and the Administrative Borrower, the option to provide to the Borrowers all or
any part of any Loan that such Granting Lender would otherwise be obligated to make to the Borrowers pursuant to this Agreement; provided that (i) nothing herein shall constitute a commitment by any SPC to make any Loan, (ii) if an
SPC elects not to exercise such option or otherwise fails to provide all or any part of such Loan, the Granting Lender shall be obligated to make such Loan pursuant to the terms hereof and (iii) in no event may any Lender grant any option to provide
to the Borrowers all or any part of any Loan that such Granting Lender would have otherwise been obligated to make to the Borrowers pursuant to this Agreement to any Disqualified Institution. The making of any Loan by an SPC hereunder shall utilize
the Commitment of the Granting Lender to the same extent, and as if, such Loan were made by such Granting Lender. Each party hereto hereby agrees that (A) neither the grant to any SPC nor the exercise by any SPC of such option shall increase
the costs or expenses or otherwise increase or change the obligations of the Borrowers under this Agreement (including its obligations under Section 2.15, 2.16 or 2.17) and no SPC shall be entitled to any greater amount
under Section 2.15, 2.16 or 2.17 or any other provision of this Agreement or any other Loan Document that the Granting Lender would have been entitled to receive, unless the grant to such SPC is made with the prior written
consent of the Administrative Borrower expressly acknowledging that 

  
 194 

 Loans acquired by any Debt Fund Affiliate may (but shall not be required to) be contributed to the
Administrative Borrower or any of its subsidiaries for purposes of cancelling such Indebtedness (it being understood that any Loans so contributed shall be retired and cancelled immediately upon thereof); provided that upon any such cancellation,
the aggregate outstanding principal amount of the relevant Class of Loans shall be deemed reduced, as of the date of such contribution, by the full par value of the aggregate principal amount of the Loans so contributed and cancelled, and each
principal repayment installment with respect to the Term Loans pursuant to Section 2.10(a) shall be reduced pro rata by the full par value of the aggregate principal amount of any applicable Term Loans so contributed and cancelled. 

(h) UponNotwithstanding anything to the contrary herein, upon the request of any Lender, the Administrative Agent shall make available to such Lender
the list of Disqualified Institutions at the relevant time, and such Lender may provide the list to any potential assignee or participant on a confidential basis in accordance with Section 9.13 hereof for the purpose of verifying whether
such Person is a Disqualified Institution. 
 Section 9.06. Survival. All covenants, agreements, representations and
warranties made by the Loan Parties in the Loan Documents and in the certificates or other instruments delivered in connection with or pursuant to this Agreement or any other Loan Document shall be considered to have been relied upon by the other
parties hereto and shall survive the execution and delivery of the Loan Documents and the making of any Loan and issuance of any Letter of Credit regardless of any investigation made by any such other party or on its behalf and notwithstanding that
the Administrative Agent may have had notice or knowledge of any Default or Event of Default or incorrect representation or warranty at the time any credit is extended hereunder, and shall continue in full force and effect until the Termination
Date. The provisions of Sections 2.15, 2.16, 2.17, 9.03 and 9.13 and Article 8 shall survive and remain in full force and effect regardless of the consummation of the transactions contemplated hereby, the
repayment of the Loans, the expiration or termination of the Letters of Credit and the Revolving Credit Commitment, the occurrence of the Termination Date or the termination of this Agreement or any provision hereof but in each case, subject to the
limitations set forth in this Agreement. 
 Section 9.07. Counterparts; Integration; Effectiveness. This Agreement may be
executed in counterparts (and by different parties hereto on different counterparts), each of which shall constitute an original, but all of which when taken together shall constitute a single contract. This Agreement, the other Loan Documents, the
Intercreditor Agreements and the Fee LettersLetter
constitute the entire agreement among the parties relating to the subject matter hereof and supersede any and all previous agreements and understandings, oral or written, relating to the subject matter hereof. This Agreement shall become effective
when it has been executed by the Administrative Borrower and the Administrative Agent and when the Administrative Agent has received counterparts hereof which, when taken together, bear the signatures of each of the other parties hereto, and
thereafter shall be binding upon and inure to the benefit of the parties hereto and their respective successors and permitted assigns. Delivery of an executed counterpart of a signature page to this Agreement by facsimile or by email as a
“.pdf” or “.tiff” attachment shall be effective as delivery of a manually executed counterpart of this Agreement. 

Section 9.08. Severability. To the extent permitted by applicable Requirements of Law, any provision of any Loan Document held to
be invalid, illegal or unenforceable in any jurisdiction shall, as to such jurisdiction, be ineffective to the extent of such invalidity, illegality or unenforceability without affecting the validity, legality and enforceability of the remaining
provisions thereof; and the invalidity of a particular provision in a particular jurisdiction shall not invalidate such provision in any other jurisdiction. 

Section 9.09. Right of Setoff. At any time when an Event of Default exists, the Administrative Agent and, upon the written consent
of the Administrative Agent, each Issuing Bank and each Lender is hereby authorized at any time and from time to time, to the fullest extent permitted by applicable Requirements of Law, to set off and apply any and all deposits (general or special,
time or demand, provisional or final) at any time held and other obligations (in any currency) at any time owing by the 

  
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 Affiliate or Representative thereof to any Affiliate or Representative of the Administrative Agent, any
Issuing Bank, any Arranger, or any Lender that is a Disqualified Institution, (b) to the extent compelled by legal process in, or reasonably necessary to, the defense of such legal, judicial or administrative proceeding, in any legal, judicial
or administrative proceeding or otherwise as required by applicable Requirements of Law (in which case such Person shall (i) to the extent permitted by applicable Requirements of Law, inform the Administrative Borrower promptly in advance
thereof and (ii) except with respect to any audit or examination conducted by bank regulatory authorities, use commercially reasonable efforts to ensure that any such information so disclosed is accorded confidential treatment), (c) upon
the demand or request of any regulatory or governmental authority (including any self-regulatory body) purporting to have jurisdiction over such Person or its Affiliates (in which case such Person shall, except with respect to any audit or
examination conducted by bank accountants or any Governmental Authority or regulatory or self-regulatory authority exercising examination or regulatory authority, to the extent permitted by applicable Requirements of Law, (i) inform the
Administrative Borrower promptly in advance thereof and (ii) use commercially reasonable efforts to ensure that any information so disclosed is accorded confidential treatment), (d) to any other party to this Agreement, (e) subject to
an acknowledgment and agreement by the relevant recipient that the Confidential Information is being disseminated on a confidential basis (on substantially the terms set forth in this paragraph or as otherwise reasonably acceptable to the
Administrative Borrower and the Administrative Agent, including as set forth in the Information Memorandum) in accordance with the standard syndication process of the Arrangers or market standards for dissemination of the relevant type of
information, which shall in any event require “click through” or other affirmative action on the part of the recipient to access the Confidential Information and acknowledge its confidentiality obligations in respect thereof, to
(i) any Eligible Assignee of or Participant in, or any prospective Eligible Assignee of or prospective Participant in, any of its rights or obligations under this Agreement, including any SPC (in each case other than a Disqualified
Institution), (ii) any pledgee referred to in Section 9.05, (iii) any actual or prospective, direct or indirect contractual counterparty (or its advisors, but other than any Disqualified Institution) to any Derivative
Transaction (including any credit default swap) or similar derivative instrument to which any Loan Party is a party and (iv) subject to the Administrative Borrower’s prior approval of the information to be disclosed, (x) to
Moody’s or S&P on a confidential basis in connection with obtaining or maintaining ratings as required under Section 5.13 or (y) to the CUSIP Service Bureau or any similar agency in connection with the issuance and
monitoring of CUSIP numbers with respect to the facilities or, on a confidential basis, market data collectors and service providers to the Administrative Agent in connection with the administration and management of this Agreement and the Loan
Documents, (f) with the prior written consent of the Administrative Borrower and (g) to the extent the Confidential Information becomes publicly available other than as a result of a breach of this Section by such Person, its Affiliates
or their respective Representatives or to the extent any such information (I) is received by such Person from a third party that is not to such Person’s knowledge, after reasonable investigation, subject to confidentiality obligations
owing to the Administrative Borrower, the Sponsors or any of their respective affiliates or Related Parties or (II) was already in such Person’s possession (except to the extent received in a manner that would be restricted by this paragraph)
or is independently developed by such Person based exclusively on information the disclosure of which would not otherwise be restricted by this paragraph. For purposes of this Section, “Confidential Information” means all
information relating to the Administrative Borrower and/or any of its subsidiaries and their respective businesses or the Transactions (including any information obtained by the Administrative Agent, any Issuing Bank, any Lender or any Arranger, or
any of their respective Affiliates or Representatives, based on a review of any books and records relating to the Administrative Borrower and/or any of its subsidiaries and their respective Affiliates from time to time, including prior to the date
hereof) other than any such information that is publicly available to the Administrative Agent or any Arranger, Issuing Bank or Lender on a non-confidential basis prior to disclosure by the Administrative Borrower or any of its subsidiaries. For the
avoidance of doubt, but subject to Section 9.05(h), in no event shall any disclosure of any Confidential Information be made to
Person that is a Disqualified Institution at the time of disclosure. 
 Section 9.14. No Fiduciary Duty. Each of the
Administrative Agent, the Arrangers, each Lender, each Issuing Bank and their respective Affiliates (collectively, solely for purposes of this paragraph, the “Lenders”), may have economic interests that conflict with those of the
Loan Parties, their stockholders and/or 

  
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 sum adjudged to be so due in the Judgment Currency, the Administrative Agent may in accordance with normal
banking procedures purchase the Agreement Currency with the Judgment Currency. If the amount of the Agreement Currency so purchased is less than the sum originally due to the Administrative Agent from any Borrower in the Agreement Currency, such
Borrower agrees, as a separate obligation and notwithstanding any such judgment, to indemnify the Administrative Agent or the Person to whom such obligation was owing against such loss. If the amount of the Agreement Currency so purchased is greater
than the sum originally due to the Administrative Agent in such currency, the Administrative Agent agrees to return the amount of any excess to such Borrower (or to any other Person who may be entitled thereto under applicable Requirements of Law).

 [THE REMAINDER OF
THIS PAGE IS INTENTIONALLY LEFT BLANK] 

[SIGNATURE PAGES
FOLLOW] 

  
 206 

 EXHIBIT B 

[See attached.] 

 [Execution Version] 

SUCCESSOR AGENT AGREEMENT 

THIS SUCCESSOR AGENT AGREEMENT (this “Agreement”) is dated as of March 26, 2019 by and among JPMORGAN CHASE BANK, N.A.
(“JPMorgan” or the “Successor Agent”), CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH (“Credit Suisse”), in its capacities as administrative agent and collateral agent (in such capacity, the
“Existing Agent”) and as issuing bank (in such capacity, the “Resigning Issuing Bank”), SYNEOS HEALTH, INC. (f/k/a INC Research Holdings, Inc.), a Delaware corporation (the “Administrative
Borrower”). 
 WHEREAS, (a) the Administrative Borrower, the banks, financial institutions and other Persons from time to time
parties thereto, and Credit Suisse, as administrative agent and collateral agent (collectively, such capacities, the “Agent”) and as issuing bank (in such capacity, an “Issuing Bank”), entered into that certain
Credit Agreement dated as of August 1, 2017 (as amended by Amendment No. 1 and as further amended, amended and restated, supplemented or otherwise modified from time to time, the “Credit Agreement”) and
(b) substantially concurrently with the effectiveness of this Agreement, the Administrative Borrower, the other Loan Parties party thereto, JPMorgan, as Successor Agent and the Lenders party thereto (which constitute the Required Lenders)
entered into that certain Amendment No. 2 to Credit Agreement, dated as of March 26, 2019 (the “Second Amendment”, and the Credit Agreement as amended by the Second Amendment, the “Amended Credit
Agreement”). Capitalized terms used herein without definition shall have the meanings attributed to such terms in the Credit Agreement and the Second Amendment, as applicable; 

WHEREAS, pursuant to Article 8 of the Credit Agreement, the Existing Agent has the right to resign as Agent and the Required Lenders have the
right, with the consent of the Administrative Borrower, to appoint a successor Agent; 
 WHEREAS, (i) pursuant to Article 8 of the
Credit Agreement, Credit Suisse desires to resign as Agent and (ii) the Required Lenders have consented to the appointment of JPMorgan to act as the successor Agent under the Credit Agreement and the other Loan Documents pursuant to the Second
Amendment; 
 WHEREAS, JPMorgan is willing to accept such appointment as Agent under the Credit Agreement and the other Loan Documents; 

WHEREAS, pursuant to Section 2.05(i)(iii) of the Credit Agreement, an Issuing Bank may resign upon notice to the Administrative Borrower,
the Revolving Lenders and each other Issuing Bank; 
 WHEREAS, (i) pursuant to Section 2.05(i)(iii) of the Credit Agreement,
Credit Suisse desires to resign as Issuing Bank and (ii) the Administrative Borrower and, pursuant to the Second Amendment, the Revolving Lenders and other Issuing Banks acknowledge notice of such resignation; 

NOW, THEREFORE, for good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged by each of the parties
hereto, the parties hereto, intending to be legally bound, hereby agree as follows: 

 1. Resignation and Appointment of Agent; Resignation of Issuing Bank. 

(a) Pursuant to the Loan Documents (including, without limitation, Article 8 of the Credit Agreement) (a) the Existing Agent’s
resignation as the Agent is hereby effective and the Administrative Borrower hereby accepts and, pursuant to the Second Amendment, each of the Required Lenders have accepted the resignation of Credit Suisse as Agent under the Loan Documents, and
Credit Suisse shall have no further obligations under the Loan Documents in its capacity as Agent (other than the obligations set forth in Section 6 below), and (b) pursuant to the Second Amendment, the Required Lenders have consented to
the appointment of JPMorgan to act as the Successor Agent, under the Loan Documents and the Administrative Borrower hereby consents to such appointment, in each case, effective as of the Effective Date (as defined below). As of the Effective Date,
the Successor Agent hereby accepts the appointment to act as the Agent under the Loan Documents. Each of the parties hereto agrees to execute all documents necessary to evidence and give effect to the appointment of JPMorgan as Agent as contemplated
by this Agreement. 
 (b) Pursuant to the Loan Documents (including, without limitation, Section 2.05(i)(iii) of the Credit Agreement),
the Resigning Issuing Bank’s resignation as Issuing Bank is hereby effective and Credit Suisse on and from the date hereof shall have no further obligations to issue Letters of Credit under the Loan Documents in its capacity as an Issuing Bank;
provided that, it is understood and agreed that the rights and obligations of Credit Suisse in its capacity as an Issuing Bank with respect to all outstanding Existing Credit Suisse Letters of Credit (as defined in the Amended Credit
Agreement) shall continue in full force and effect. The Administrative Borrower hereby waives, and pursuant to the Second Amendment each other Issuing Bank and the Revolving Lenders have waived, any notice requirements and, other than as set forth
herein with respect to the Existing Credit Suisse Letters of Credit, any inconsistency or conflict with the provisions in Section 2.05(i)(iii) of the Credit Agreement with respect to the resignation of Credit Suisse as Issuing Bank. 

2. Rights, Duties and Obligations. 

(a) As of the Effective Date, the Successor Agent is hereby vested with all the rights, powers, discretion and privileges of the Agent, as
described in the Loan Documents, and the Successor Agent assumes from and after the Effective Date the obligations, responsibilities and duties of the Agent, in accordance with the terms of the Loan Documents, and, except as set forth in
Section 6 below, the Existing Agent is discharged from all of its duties and obligations as the Agent under the Loan Documents. Nothing in this Agreement shall be deemed a termination of the provisions of any Loan Document that expressly
survive Credit Suisse’s resignation in its capacity as Agent (including, without limitation, Article 8 and Section 9.03 of the Credit Agreement (collectively, the “Agency Surviving Provisions”)), which provisions shall
inure to the benefit of the Existing Agent (and, as and to the extent provided therein, each other sub-agents appointed by it) as to any actions taken or omitted to be taken while it was “Agent”
under the Credit Agreement and the other Loan Documents. 
 (b) The Administrative Borrower and, pursuant to the Second Amendment, the
Required Lenders expressly agree and acknowledge that the Successor Agent is not assuming any liability (i) under or related to the Loan Documents prior to the Effective Date and (ii) for any and all claims under or related to the Loan
Documents that may have arisen or accrued prior to the Effective Date. 
 (c) The Administrative Borrower hereby expressly agrees and
confirms and the Required Lenders have agreed and confirmed pursuant to the Second Amendment, with respect to their applicable indemnification obligations under the Loan Documents, that the Existing Agent’s right to indemnification, as set
forth in the Loan Documents, shall apply with respect to any and all losses, claims, costs and expenses that the Existing Agent, suffers or incurs relating to actions taken or omitted by any of the parties to this Agreement prior to the Effective
Date. 

  
 2 

 (d) The parties hereto agree that neither Credit Suisse, in its individual capacity and in
its capacity as the Existing Agent, nor any of its Affiliates, shall bear any responsibility or liability for any actions taken or omitted to be taken by the Successor Agent or otherwise under this Agreement or, on and after the Effective Date, the
Credit Agreement or any of the other Loan Documents. 
 (e) As of the Effective Date, the Resigning Issuing Bank is discharged from all of
its duties and obligations as an Issuing Bank under the Loan Documents, except as set forth in Section 2.05(i)(iii) of the Credit Agreement with respect to the Existing Credit Suisse Letters of Credit. Notwithstanding anything to the contrary
herein, nothing in this Agreement shall be deemed a termination of the provisions of any Loan Document that expressly survive Credit Suisse’s resignation in its capacity as Issuing Bank (including, without limitation, Sections 2.05 and 9.03 of
the Credit Agreement (the “Letter of Credit Surviving Provisions”, and together with the Agency Surviving Provisions, the “Surviving Provisions”)), which provisions shall inure to the benefit of the Resigning
Issuing Bank as to any actions taken or omitted to be taken while it was “Issuing Bank” under the Credit Agreement and the other Loan Documents. The Administrative Borrower hereby expressly agrees and confirms and the Revolving Lenders and
Issuing Banks have agreed and confirmed pursuant to the Second Amendment, with respect to their applicable indemnification obligations under the Loan Documents, that the Resigning Issuing Bank’s right to indemnification, as set forth in the
Loan Documents, shall apply with respect to any and all losses, claims, costs and expenses that the Resigning Issuing Bank suffers or incurs relating to actions taken or omitted by any of the parties to this Agreement prior to the Effective Date.

 3. Information Regarding Status of Loan Documents. 

(a) Current Lenders and Loan Status. Attached hereto as Schedule I is the Register maintained by the Existing Agent, which
Register the Existing Agent represents and warrants contains a true and correct list of the Lenders and the outstanding principal amount of, and accrued interest payable on, the Loans owing to each such Lender under the Credit Agreement as of close
of business on March 26, 2019. 
 (b) Collateral Documents. The Existing Agent represents and warrants that Schedule II is a
list of the Collateral Documents, copies of which have been delivered to the Successor Agent on or prior to the date hereof, and as of the date hereof there have been no amendments, supplements or consents to the Collateral Documents, to which the
Existing Agent has knowledge or is a party, except as set forth on Schedule II. 
 (c) Waivers. The Administrative Borrower
hereby waives, and pursuant to the Second Amendment the Required Lenders have waived, any notice requirements and any inconsistency or conflict with the provisions in Article 8 of the Credit Agreement with respect to the resignation of Credit Suisse
as Agent and the appointment of JPMorgan as the Agent. 
 Other than as expressly set forth herein, this Agreement is made without
representation or warranty of any kind, nature or description on the part of any party hereto; provided that the foregoing shall not affect any of the covenants or agreements contained in the other paragraphs hereof. Without limiting the
generality of the foregoing, the Successor Agent acknowledges that the Existing Agent has not made any representation or warranty to the Successor Agent as to the financial condition of the Administrative Borrower or the value, collectability or
realization of any Collateral or any Obligations of the Loan Parties or as to the legality, validity, enforceability, perfection or priority of any Obligations of the Loan Parties or the Collateral. The Successor Agent acknowledges that it has made,
to the extent determined by it to be necessary or prudent, its own independent investigation and determination of the foregoing matters and all other matters pertaining to its appointment as Agent under the Loan Documents. 

  
 3 

 4. Collateral. 

(a) The Existing Agent hereby assigns to the Successor Agent each of the Liens and security interests pledged, collaterally assigned,
mortgaged, transferred and granted to the Existing Agent in its capacity as the Agent under the Collateral Documents for its benefit and the benefit of the Secured Parties, together with any claims, awards, and judgments, if any, in favor of the
Existing Agent in its capacity as the Agent under the Collateral Documents, and the Successor Agent hereby assumes all such Liens and security interests, for its benefit and for the benefit of the Secured Parties. For the avoidance of doubt, nothing
in the foregoing sentence shall require the Existing Agent to assign to the Successor Agent any fees or expenses or any claims, awards or judgments relating to indemnity, reimbursement or other protections to which the Existing Agent is entitled
under the Loan Documents (in its capacity as the Agent) received or incurred by, or due to, the Existing Agent prior to the Effective Date. 

(b) The Administrative Borrower (and the Administrative Borrower on behalf of the other Loan Parties), and the Existing Agent hereby authorize
the Successor Agent (or its counsel on its behalf) to (i) file, on or after the date hereof, the UCC financing statements set forth in Annex A-1 hereto, (ii) make the filings with the United States
Patent and Trademark Office and the United States Copyright Office set forth in Annex A-2 hereto, and (iii) with the prior consent of the Administrative Borrower, any other UCC assignments or other
assignments and amendments with respect to the UCC financing statements and other filings in respect of the Collateral, and to execute such other agreements or amendments in respect of the Collateral and the Collateral Documents, including filings
with the United States Patent and Trademark Office and the United States Copyright Office and assignments and/or amendments to account control agreements, as the Successor Agent reasonably deems necessary or appropriate to evidence the Successor
Agent’s appointment as Agent pursuant to the terms of this Agreement effective as of the Effective Date. 
 (c) The Successor Agent
shall act in good faith to take possession and control of all Collateral and Liens in the possession or control of the Existing Agent (the “Possessory Collateral”), and the Existing Agent shall act in good faith to deliver all
Possessory Collateral to the Successor Agent (or its designated counsel), in each case as expeditiously as possible following the Effective Date. Until such time as all Collateral in the possession or control of the Existing Agent (in its capacity
as such), all Liens granted in favor of the Existing Agent (in its capacity as such) in the Collateral and all UCC-1 financing statements and other filings and registrations (including any documents filed or
registered with the United States Copyright Office or the United States Patent and Trademark Office) that name Credit Suisse as Agent as a secured party have been assigned or otherwise transferred to the Successor Agent, if applicable, the Existing
Agent shall continue to hold such Collateral and/or Liens on such Collateral as bailee of the Successor Agent in accordance with the terms of this Agreement and the Collateral Documents, solely for the purposes of maintaining the priority and
perfection of such Liens. Credit Suisse, in its capacity as Existing Agent, shall be entitled to all the benefits of the Agent under the Loan Documents (including, without limitation, the Agency Surviving Provisions) with respect to all actions
taken or omitted to be taken by Credit Suisse in its capacity as the Agent prior to the Effective Date, including, for the avoidance of doubt, in connection with this Agreement. 

(d) Any reference to the Existing Agent as an additional insured and/or loss payee under any insurance required to be maintained pursuant to
the Loan Documents shall, until the Successor Agent is substituted as additional insured and/or loss payee thereunder, constitute a reference to the Existing Agent as sub-agent of the Successor Agent. 

  
 4 

 5. Conditions Precedent to Effectiveness. This Agreement shall become effective, as
of the date hereof (the “Effective Date”), upon the satisfaction of the following conditions (it being understood and agreed that the effectiveness of this agreement shall occur substantially concurrently with, but immediately prior to,
the Amendment No. 2 Closing Date): 
 (a) each of the parties hereto shall have received executed counterparts of this Agreement from
the Administrative Borrower, the Existing Agent, the Successor Agent and the Resigning Issuing Bank; 
 (b) the parties thereto (which shall
include the Required Lenders) shall have executed and delivered the Second Amendment; and 
 (c) the Administrative Borrower shall have
reimbursed each of the Existing Agent and the Resigning Issuing Bank for all reasonable and documented out-of-pocket fees, charges and expenses due and payable as of the
Effective Date (including the reasonable fees and disbursements of external counsel to the Existing Agent and Resigning Issuing Bank through and including the Effective Date). 

6. Covenants of Existing Agent and the Loan Parties. 

(a) The Existing Agent covenants and agrees that it will: (i) use commercially reasonable efforts to deliver, or cause to be delivered,
promptly to the Successor Agent, (x) executed originals of the Credit Agreement and the other Loan Documents in its possession to the extent the Successor Agent reasonably deems it is necessary to have such executed original documents and
(y) copies of any written notices, financial statements and other written requests delivered by the Administrative Borrower, in accordance with the notice provisions in Section 9.01 of the Credit Agreement, to the Existing Agent under
Article 5 of the Credit Agreement received by the Existing Agent, in each case, to the extent such notices, statements or requests have not already been delivered to the Lenders, (ii) execute all documents as may be reasonably requested by the
Successor Agent to transfer the rights and privileges of the Existing Agent under the Loan Documents, in its capacity as Agent, to the Successor Agent and (iii) take all other actions reasonably requested by the Successor Agent or its
representatives to facilitate the transfer of information to the Successor Agent in connection with the Loan Documents, including to comply with its obligations under Article 8 of the Credit Agreement. The Administrative Borrower hereby consents
(and the Required Lenders pursuant to the Second Amendment have consented) to all actions taken by the Existing Agent and the Successor Agent pursuant to the immediately preceding sentence; provided that, notwithstanding anything to the
contrary, it is acknowledged by the Successor Agent, for the avoidance of doubt, that the confidentiality provisions of the Loan Documents, including, without limitation Section 9.13 of the Credit Agreement, shall apply to all information
regarding the Administrative Borrower and its Subsidiaries and their businesses delivered to the Successor Agent in accordance with such provisions regardless of whether such information was delivered on, before or after the Effective Date. It is
the intention and understanding of the Existing Agent and the Successor Agent that any exchange of information under this Section 6 that is otherwise protected against disclosure by privilege, doctrine or rule of confidentiality (such
information, “Privileged Information”) (i) will not waive any applicable privilege, doctrine or rule of protection from disclosure, (ii) will not diminish the confidentiality of the Privileged Information and (iii) will not be
asserted as a waiver of any such privilege, doctrine or rule by the Existing Agent or the Successor Agent. 
 (b) The Administrative Borrower
(and the Administrative Borrower on behalf of the other Loan Parties) and the Existing Agent agree that, promptly following the Effective Date, the Existing Agent shall (i) furnish, at the Administrative Borrower’s expense, additional
releases, amendment or termination statements, assignments, acknowledgements, such other customary documents, instruments and agreements and such other information as may be reasonably requested by the Successor Agent from 

  
 5 

 time to time and, in each case, that are necessary to evidence the Successor Agent’s appointment as
Agent effective as of the Effective Date and (ii) take such actions with respect to the Collateral as may be reasonably requested by the Successor Agent from time to time that are necessary in order to effect the matters covered hereby;
provided that any document, instrument or agreement to be furnished or executed by, or other action to be taken by, the Existing Agent shall be reasonably satisfactory to it and shall be without any representations and/or warranties from the
Existing Agent, and the Existing Agent shall be reasonably satisfied that the delivery of any information requested of it would not breach any confidentiality restrictions binding on it. 

7. Fees and Expenses. Commencing on the Effective Date, the Existing Agent shall cease to be entitled to receive the administrative
agent fees provided by that certain agency fee letter, dated as of June 14, 2017 (the “Existing Agent Fee Letter”), between, among others, the Administrative Borrower and the Existing Agent and, notwithstanding anything to the
contrary in the Credit Agreement, commencing on and after the Effective Date, the administrative agent fees shall be payable to the Successor Agent pursuant to that certain Agency Fee Letter, dated as of February 14, 2019 (the
“Successor Agent Fee Letter”), by and among the Administrative Borrower and JPMorgan Chase Bank, N.A.. All other provisions of the Credit Agreement providing for the payment of fees and expenses of, and providing indemnities for the
benefit of, the Existing Agent shall remain in full force and effect for the benefit of the Successor Agent. In addition, to the extent required by Section 9.03 of the Credit Agreement, the Administrative Borrower agrees to pay all reasonable out-of-pocket costs and expenses of the Existing Agent and the Successor Agent (including, without limitation, legal fees) reasonably incurred by it in connection with the
negotiation, preparation, execution and delivery of this Agreement and any related documents. 
 8. Return of Payments. In the event
that, after the Effective Date, the Existing Agent receives any principal, interest or other amount owing to any Lender or the Successor Agent under any Loan Document, the Existing Agent agrees that such payment shall be held in trust for the
Successor Agent, and the Existing Agent shall promptly return without setoff or counterclaim such payment to the Successor Agent for payment to the Person entitled thereto. 

9. Indemnification. The Administrative Borrower (and the Administrative Borrower on behalf of the other Loan Parties) confirms and
agrees that the indemnification provisions set forth in Section 9.03 of the Credit Agreement will apply and be enforceable by the Existing Agent, the Successor Agent and the Resigning Issuing Bank in respect of their respective execution and
delivery of this Agreement and the other instruments and agreements provided for herein, all actions taken or omitted by the Existing Agent, the Successor Agent and the Resigning Issuing Bank pursuant to the terms of this Agreement and all claims
based upon or arising in connection with any of the foregoing. Each of the Existing Agent, the Successor Agent and the Resigning Issuing Bank reserves the right to enforce, in respect of such execution, delivery, actions or claims, each and all of
the rights, benefits, immunities, exculpatory provisions and indemnities enforceable by the Existing Agent, the Successor Agent and the Resigning Issuing Bank (as applicable) under the Surviving Provisions. 

10. Entire Agreement. This Agreement, the Second Amendment and, solely as between the Administrative Borrower and the Successor Agent,
the Successor Agent Fee Letter state the entire agreement and supersede all prior agreements, written or verbal, between the parties hereto with respect to the subject matter hereof and this Agreement may not be amended except in writing signed by a
duly authorized representative of each of the respective parties hereto. Except as specifically modified by this Agreement, the Credit Agreement and the other Loan Documents are hereby ratified and confirmed in all respects and shall remain in full
force and effect in accordance with their respective terms. 

  
 6 

 11. Waiver. No delay or failure on the part of any party hereto in exercising any
right, power or remedy hereunder shall effect or operate as a waiver thereof, nor shall any single or partial exercise thereof or any abandonment or discontinuance of steps to enforce such right, power or remedy preclude any further exercise thereof
or of any other right, power or remedy. 
 12. Submission To Jurisdiction; Waiver of Right to Trial by Jury. The parties hereby agree
that Sections 9.10(b) and 9.11 of the Credit Agreement shall apply, mutatis mutandis, to this Agreement. 
 13. Consents. The
Administrative Borrower hereby represents and warrants that it is duly authorized to execute and perform its obligations under this Agreement and that such execution is not prohibited by law and the Administrative Borrower hereby consents to the
appointment of JPMorgan as Successor Agent under the Credit Agreement and the other applicable Loan Documents. 
 14. Representations and
Warranties. Each of the Existing Agent and the Successor Agent hereby represents and warrants that it is duly authorized to execute and perform its obligations under this Agreement and that such execution is not prohibited by law. 

15. Successors and Assigns. This Agreement shall inure to the benefit and be binding upon the successors and permitted assigns of each
of the parties hereto. 
 16. Amendments. The parties hereby agree and acknowledge that, from and after the Effective Date, JPMorgan
shall be, and shall be deemed to be, the Agent under the Credit Agreement and the other Loan Documents. In furtherance of the foregoing, as of the Effective Date, unless the context otherwise requires, all recitals, introductory paragraphs, defined
terms and other references to “Credit Suisse AG, Cayman Islands Branch” as the administrative agent and/or the collateral agent in the Credit Agreement and the other Loan Documents are hereby deemed amended to reference “JPMorgan
Chase Bank, N.A.” as the Agent, thereunder. 
 17. Notices. All notices addressed to the “Administrative Agent” under
the Credit Agreement or the other Loan Documents shall be sent to: 
 JPM Account Manager 

Client Processing Specialist 
 10
South Dearborn, Floor L2 
 Chicago, IL 60603-2300, United States 

Attention: Stephon Chambers 

Telephone: 312-954-4306 

Facsimile: 844-490-5665 

Email: Jpm.agency.servicing.1@jpmorgan.com; Stephon.Chambers@JPMorgan.com 

with a copy to 
 JPM Backup
Account Manager 
 Client Processing Specialist 

10 South Dearborn, Floor L2 

Chicago, IL 60603-2300, United States 

Attention: Ladesiree Williams 

Telephone: 312-732-2007 

Facsimile: 844-490-5665 

Email: Jpm.agency.servicing.1@jpmorgan.com 

  
 7 

 18. GOVERNING LAW. THIS AGREEMENT SHALL BE GOVERNED BY, AND SHALL BE CONSTRUED IN
ACCORDANCE WITH, THE LAWS OF THE STATE OF NEW YORK (INCLUDING NEW YORK GENERAL OBLIGATIONS LAW SECTION 5-1401). 

19. Severability. In the event that any provision of this Agreement, or the application of such provision to any Person or set of
circumstances, shall be determined to be invalid, unlawful, void or unenforceable to any extent, the remainder of this Agreement, and the application of such provision to Persons or circumstances other than those as to which it is determined to be
invalid, unlawful, void or unenforceable, shall not be affected and shall continue to be valid and enforceable to the fullest extent permitted by law. 

20. Loan Documents. Upon the execution and delivery of this Agreement by the Existing Agent, the Successor Agent and the Administrative
Borrower, this Agreement shall be deemed to be a Loan Document, and the Credit Agreement and the other Loan Documents shall, where the context requires, be read and construed throughout so as to incorporate this Agreement. 

21. Counterparts and Facsimile. This Agreement may be signed in counterparts, all of which together shall constitute one and the same
instrument. The parties hereto may provide signatures to this Agreement by facsimile or electronic mail (including, without limitation, in “.pdf” or “.tif” format), and such facsimile or electronic mail signatures shall be deemed
to be the same as original signatures. 
 [Signature Pages Follow] 

  
 8 

 IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed and
delivered by their respective duly authorized officers as of the date first above written. 
  

			
	CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH, 
as Existing Agent
		
	By:	 	 /s/ Vipul Dhadda

		 	 Name: Vipul Dhadda
 Title: Authorized
Signatory

		
	By:	 	 /s/ Joan Park

		 	 Name: Joan Park
 Title: Authorized
Signatory

  
 [Signature Page to
Successor Agent Transfer Agreement] 

 
			
	CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH, 
as the Resigning Issuing Bank
		
	By:	 	 /s/ Vipul Dhadda

		 	 Name: Vipul Dhadda
 Title: Authorized
Signatory

		
	By:	 	 /s/ Joan Park

		 	 Name: Joan Park
 Title: Authorized
Signatory

 [Signature Page to Successor Agent Transfer Agreement] 

 
					
	JPMORGAN CHASE BANK, N.A. 
as the Successor Agent
		
	By:	 	 /s/ John Kusnerick

		 	 Name: John Kushnerick
 Title:
Executive Director

  
 [Signature Page to
Successor Agent Transfer Agreement] 

			
	SYNEOS HEALTH, INC., as the Administrative Borrower
		
	By:	 	 /s/ Jason Meggs

		 	Name: Jason Meggs
		 	Title: Chief Financial Officer

  
 [Signature Page to
Successor Agent Transfer Agreement] 

 Schedule I 

[Separately provided to the Successor Agent] 

 Schedule II 

Collateral Documents 
  

	1.	 Perfection Certificate dated August 1, 2017 (as amended, restated, amended and restated, supplemented or
otherwise modified and in effect on the date hereof) between the Borrower, the other Loan Parties from time to time party thereto and the Existing Agent, as collateral agent and administrative agent for the secured parties. 

 

	2.	 Perfection Certificate dated March 1, 2018 by Taylor Strategy Partners, LLC. 

 

	3.	 Pledge and Security Agreement dated August 1, 2017 (as amended, restated, amended and restated,
supplemented or otherwise modified and in effect on the date hereof) between the Borrower, the other borrowers from time to time party thereto, the Grantors from time to time party thereto and the Existing Agent, as collateral agent and
administrative agent for the secured parties. 

  

	4.	 Loan Guaranty dated August 1, 2017 (as amended, restated, amended and restated, supplemented or otherwise
modified and in effect on the date hereof) between the Borrower, the other borrowers from time to time party thereto, the Subsidiary Parties from time to time party thereto and the Existing Agent, as collateral agent and administrative agent for the
secured parties. 

  

	5.	 Intellectual Property Security Agreement dated August 1, 2017 among the Grantors from time to time party
thereto and the Existing Agent, as collateral agent and administrative agent for the secured parties. 

  

	6.	 Intellectual Property Security Agreement dated as of March 1, 2018 among Taylor Strategy Partners, LLC and
the Existing Agent, as collateral agent and administrative agent for the secured parties. 

  

	7.	 Joinder to (i) the Pledge and Security Agreement and (ii) the Loan Guaranty, dated as of
March 1, 2018 by Taylor Strategy Partners, LLC. 

 Annex A-1 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212)
450-6018                B. E-MAIL CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] 2017 5090169 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. X ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8    4. CONTINUATION: Effectiveness of the Financing Statement identified above with respect to the security
interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable law                5. PARTY
INFORMATION CHANGE:                Check one of these two boxes: AND Check one of these three boxes
to:                CHANGE name and/or address: Complete ADD name: Complete item DELETE name: Give record name This Change affects Debtor or Secured Party of record item
6a or 6b; and item 7a or 7b and item 7c 7a or 7b, and item 7c to be deleted in item 6a or 6b 6. CURRENT RECORD INFORMATION: Complete for Party Information Change—provide only one name (6a or
6b)                6a. ORGANIZATION’S NAME                OR 6b. INDIVIDUAL’S
SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any
part of the Debtor’s name) 7a. ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR                7b. INDIVIDUAL’S
SURNAME                INDIVIDUAL’S FIRST PERSONAL
NAME                INDIVIDUAL’S ADDITIONAL NAME(S)/INITIAL(S)                SUFFIX
7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago IL 60603-2300 USA 8. COLLATERAL CHANGE: Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate
collateral:                9. NAME OF SECURED PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment)
If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing Debtor                9a. ORGANIZATION’S
NAME                Credit Suisse AG, Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL
NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE DATA:                F#586239 Filed with: DE—Secretary of State; Debtor: ADHERIS, LLC CM:21076/009
A#938139     FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212)
450-6018                B. E-MAIL CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] 2017 5090185 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. X ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8    4. CONTINUATION: Effectiveness of the Financing Statement identified above with respect to the security
interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable law                5. PARTY
INFORMATION CHANGE:                Check one of these two boxes: AND Check one of these three boxes
to:                CHANGE name and/or address: Complete ADD name: Complete item DELETE name: Give record name This Change affects Debtor or Secured Party of record item
6a or 6b; and item 7a or 7b and item 7c 7a or 7b, and item 7c to be deleted in item 6a or 6b 6. CURRENT RECORD INFORMATION: Complete for Party Information Change—provide only one name (6a or
6b)                6a. ORGANIZATION’S NAME                OR 6b. INDIVIDUAL’S
SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any
part of the Debtor’s name) 7a. ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR                7b. INDIVIDUAL’S
SURNAME                INDIVIDUAL’S FIRST PERSONAL
NAME                INDIVIDUAL’S ADDITIONAL NAME(S)/INITIAL(S)                SUFFIX
7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago IL 60603-2300 USA 8. COLLATERAL CHANGE: Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate
collateral:                9. NAME OF SECURED PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment)
If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing Debtor                9a. ORGANIZATION’S
NAME                Credit Suisse AG, Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL
NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE DATA:                F#586240 Filed with: DE—Secretary of State; Debtor: ALLIDURA COMMUNICATIONS, LLC CM:
21076/009 A#938140     FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212)
450-6018                B. E-MAIL CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] 2017 5089690 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. X ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8    4. CONTINUATION: Effectiveness of the Financing Statement identified above with respect to the security
interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable law                5. PARTY
INFORMATION CHANGE:                Check one of these two boxes: AND Check one of these three boxes
to:                CHANGE name and/or address: Complete ADD name: Complete item DELETE name: Give record name This Change affects Debtor or Secured Party of record item
6a or 6b; and item 7a or 7b and item 7c 7a or 7b, and item 7c to be deleted in item 6a or 6b 6. CURRENT RECORD INFORMATION: Complete for Party Information Change—provide only one name (6a or
6b)                6a. ORGANIZATION’S NAME                OR 6b. INDIVIDUAL’S
SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any
part of the Debtor’s name) 7a. ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR                7b. INDIVIDUAL’S
SURNAME                INDIVIDUAL’S FIRST PERSONAL
NAME                INDIVIDUAL’S ADDITIONAL NAME(S)/INITIAL(S)                SUFFIX
7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago IL 60603-2300 USA 8. COLLATERAL CHANGE: Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate
collateral:                9. NAME OF SECURED PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment)
If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing Debtor                9a. ORGANIZATION’S
NAME                Credit Suisse AG, Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL
NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE DATA:                F#586206 Filed with: DE—Secretary of State; Debtor: CHAMBERLAIN COMMUNICATIONS GROUP LLC
CM: 21076/009 A#938144     FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212)
450-6018                B. E-MAIL CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] 2017 5089757 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. X ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8    4. CONTINUATION: Effectiveness of the Financing Statement identified above with respect to the security
interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable law                5. PARTY
INFORMATION CHANGE:                Check one of these two boxes: AND Check one of these three boxes
to:                CHANGE name and/or address: Complete ADD name: Complete item DELETE name: Give record name This Change affects Debtor or Secured Party of record item
6a or 6b; and item 7a or 7b and item 7c 7a or 7b, and item 7c to be deleted in item 6a or 6b 6. CURRENT RECORD INFORMATION: Complete for Party Information Change—provide only one name (6a or
6b)                6a. ORGANIZATION’S NAME                OR 6b. INDIVIDUAL’S
SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any
part of the Debtor’s name) 7a. ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR                7b. INDIVIDUAL’S
SURNAME                INDIVIDUAL’S FIRST PERSONAL
NAME                INDIVIDUAL’S ADDITIONAL NAME(S)/INITIAL(S)                SUFFIX
7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago IL 60603-2300 USA 8. COLLATERAL CHANGE: Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate
collateral:                9. NAME OF SECURED PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment)
If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing Debtor                9a. ORGANIZATION’S
NAME                Credit Suisse AG, Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL
NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE DATA:                F#586209 Filed with: DE—Secretary of State; Debtor: INCHORD HOLDING CORPORATION CM:
21076/009 A#938147     FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212)
450-6018                B. E-MAIL CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] 2017 5089781 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. X ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8                4. CONTINUATION: Effectiveness of
the Financing Statement identified above with respect to the security interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable
law                5. PARTY INFORMATION CHANGE:                Check one of these two
boxes: AND Check one of these three boxes to:                CHANGE name and/or address: Complete ADD name: Complete item DELETE name: Give record name This Change
affects Debtor or Secured Party of record item 6a or 6b; and item 7a or 7b and item 7c 7a or 7b, and item 7c to be deleted in item 6a or 6b 6. CURRENT RECORD INFORMATION: Complete for Party Information Change—provide only one name (6a or
6b)                6a. ORGANIZATION’S NAME                OR 6b. INDIVIDUAL’S
SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any
part of the Debtor’s name) 7a. ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR                7b. INDIVIDUAL’S
SURNAME                INDIVIDUAL’S FIRST PERSONAL
NAME                INDIVIDUAL’S ADDITIONAL NAME(S)/INITIAL(S)                SUFFIX
7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago IL 60603-2300 USA 8. COLLATERAL CHANGE: Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate
collateral:                9. NAME OF SECURED PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment)
If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing Debtor                9a. ORGANIZATION’S
NAME                Credit Suisse AG, Cayman Islands Branch, as Collateral
Agent                OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE
DATA:                F#586210 Filed with: DE—Secretary of State; Debtor: INVENTIV CLINICAL, LLC CM: 21076/009 A#938148     FILING OFFICE COPY
— UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212)
450-6018                B. E-MAIL CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] 2017 5087660 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. X ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8    4. CONTINUATION: Effectiveness of the Financing Statement identified above with respect to the security
interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable law                5. PARTY
INFORMATION CHANGE:                Check one of these two boxes: AND Check one of these three boxes
to:                CHANGE name and/or address: Complete ADD name: Complete item DELETE name: Give record name This Change affects Debtor or Secured Party of record item
6a or 6b; and item 7a or 7b and item 7c 7a or 7b, and item 7c to be deleted in item 6a or 6b 6. CURRENT RECORD INFORMATION: Complete for Party Information Change—provide only one name (6a or
6b)                6a. ORGANIZATION’S NAME                OR 6b. INDIVIDUAL’S
SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any
part of the Debtor’s name) 7a. ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR                7b. INDIVIDUAL’S
SURNAME                INDIVIDUAL’S FIRST PERSONAL
NAME                INDIVIDUAL’S ADDITIONAL NAME(S)/INITIAL(S)                SUFFIX
7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago IL 60603-2300 USA 8. COLLATERAL CHANGE: Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate
collateral:                9. NAME OF SECURED PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment)
If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing Debtor                9a. ORGANIZATION’S
NAME                Credit Suisse AG, Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL
NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE DATA:                F#586213 Filed with: DE—Secretary of State; Debtor: INVENTIV HEALTH CLINICAL, LLC CM:
21076/009 A#938150     FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212)
450-6018                B. E-MAIL CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] 2017 5089849 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. X ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8    4. CONTINUATION: Effectiveness of the Financing Statement identified above with respect to the security
interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable law                5. PARTY
INFORMATION CHANGE:                Check one of these two boxes: AND Check one of these three boxes
to:                CHANGE name and/or address: Complete ADD name: Complete item DELETE name: Give record name This Change affects Debtor or Secured Party of record item
6a or 6b; and item 7a or 7b and item 7c 7a or 7b, and item 7c to be deleted in item 6a or 6b 6. CURRENT RECORD INFORMATION: Complete for Party Information Change—provide only one name (6a or
6b)                6a. ORGANIZATION’S NAME                OR 6b. INDIVIDUAL’S
SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any
part of the Debtor’s name) 7a. ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR                7b. INDIVIDUAL’S
SURNAME                INDIVIDUAL’S FIRST PERSONAL
NAME                INDIVIDUAL’S ADDITIONAL NAME(S)/INITIAL(S)                SUFFIX
7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago IL 60603-2300 USA 8. COLLATERAL CHANGE: Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate
collateral:                9. NAME OF SECURED PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment)
If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing Debtor                9a. ORGANIZATION’S
NAME                Credit Suisse AG, Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL
NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE DATA:                F#586211 Filed with: DE—Secretary of State; Debtor: INVENTIV HEALTH CLINICAL RESEARCH
SERVICES, LLC CM: 21076/009 A#938152     FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212)
450-6018                B. E-MAIL CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] 2017 5090029 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. X ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8    4. CONTINUATION: Effectiveness of the Financing Statement identified above with respect to the security
interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable law                5. PARTY
INFORMATION CHANGE:                Check one of these two boxes: AND Check one of these three boxes
to:                CHANGE name and/or address: Complete ADD name: Complete item DELETE name: Give record name This Change affects Debtor or Secured Party of record item
6a or 6b; and item 7a or 7b and item 7c 7a or 7b, and item 7c to be deleted in item 6a or 6b 6. CURRENT RECORD INFORMATION: Complete for Party Information Change—provide only one name (6a or
6b)                6a. ORGANIZATION’S NAME                OR 6b. INDIVIDUAL’S
SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any
part of the Debtor’s name) 7a. ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR                7b. INDIVIDUAL’S
SURNAME                INDIVIDUAL’S FIRST PERSONAL
NAME                INDIVIDUAL’S ADDITIONAL NAME(S)/INITIAL(S)                SUFFIX
7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago IL 60603-2300 USA 8. COLLATERAL CHANGE: Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate
collateral:                9. NAME OF SECURED PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment)
If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing Debtor                9a. ORGANIZATION’S
NAME                Credit Suisse AG, Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL
NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE DATA:                F#586212 Filed with: DE—Secretary of State; Debtor: INVENTIV HEALTH CLINICAL SRE, LLC
CM: 21076/009 A#938153     FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212)
450-6018                B. E-MAIL CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] 2017 5090086 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. X ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8    4. CONTINUATION: Effectiveness of the Financing Statement identified above with respect to the security
interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable law                5. PARTY
INFORMATION CHANGE:                Check one of these two boxes: AND Check one of these three boxes
to:                CHANGE name and/or address: Complete ADD name: Complete item DELETE name: Give record name This Change affects Debtor or Secured Party of record item
6a or 6b; and item 7a or 7b and item 7c 7a or 7b, and item 7c to be deleted in item 6a or 6b 6. CURRENT RECORD INFORMATION: Complete for Party Information Change—provide only one name (6a or
6b)                6a. ORGANIZATION’S NAME                OR 6b. INDIVIDUAL’S
SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any
part of the Debtor’s name) 7a. ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR                7b. INDIVIDUAL’S
SURNAME                INDIVIDUAL’S FIRST PERSONAL
NAME                INDIVIDUAL’S ADDITIONAL NAME(S)/INITIAL(S)                SUFFIX
7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago IL 60603-2300 USA 8. COLLATERAL CHANGE: Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate
collateral:                9. NAME OF SECURED PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment)
If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing Debtor                9a. ORGANIZATION’S
NAME                Credit Suisse AG, Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL
NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE DATA:                F#586214 Filed with: DE—Secretary of State; Debtor: INVENTIV HEALTH PUBLIC RELATIONS,
LLC CM: 21076/009 A#938155     FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212)
450-6018                B. E-MAIL CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] 2017 5089716 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. X ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8    4. CONTINUATION: Effectiveness of the Financing Statement identified above with respect to the security
interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable law                5. PARTY
INFORMATION CHANGE:                Check one of these two boxes: AND Check one of these three boxes
to:                CHANGE name and/or address: Complete ADD name: Complete item DELETE name: Give record name This Change affects Debtor or Secured Party of record item
6a or 6b; and item 7a or 7b and item 7c 7a or 7b, and item 7c to be deleted in item 6a or 6b 6. CURRENT RECORD INFORMATION: Complete for Party Information Change—provide only one name (6a or
6b)                6a. ORGANIZATION’S NAME                OR 6b. INDIVIDUAL’S
SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any
part of the Debtor’s name) 7a. ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR                7b. INDIVIDUAL’S
SURNAME                INDIVIDUAL’S FIRST PERSONAL
NAME                INDIVIDUAL’S ADDITIONAL NAME(S)/INITIAL(S)                SUFFIX
7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago IL 60603-2300 USA 8. COLLATERAL CHANGE: Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate
collateral:                9. NAME OF SECURED PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment)
If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing Debtor                9a. ORGANIZATION’S
NAME                Credit Suisse AG, Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL
NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE DATA:                F#586208 Filed with: DE—Secretary of State; Debtor: INVENTIV HEALTH RESEARCH &
INSIGHTS, LLC CM: 21076/009 A#938156     FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212)
450-6018                B. E-MAIL CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] 20170080197G 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. X ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8    4. CONTINUATION: Effectiveness of the Financing Statement identified above with respect to the security
interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable law                5. PARTY
INFORMATION CHANGE:                Check one of these two boxes: AND Check one of these three boxes
to:                CHANGE name and/or address: Complete ADD name: Complete item DELETE name: Give record name This Change affects Debtor or Secured Party of record item
6a or 6b; and item 7a or 7b and item 7c 7a or 7b, and item 7c to be deleted in item 6a or 6b 6. CURRENT RECORD INFORMATION: Complete for Party Information Change—provide only one name (6a or
6b)                6a. ORGANIZATION’S NAME                OR 6b. INDIVIDUAL’S
SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any
part of the Debtor’s name) 7a. ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR                7b. INDIVIDUAL’S
SURNAME                INDIVIDUAL’S FIRST PERSONAL
NAME                INDIVIDUAL’S ADDITIONAL NAME(S)/INITIAL(S)                SUFFIX
7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago IL 60603-2300 USA 8. COLLATERAL CHANGE: Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate
collateral:                9. NAME OF SECURED PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment)
If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing Debtor                9a. ORGANIZATION’S
NAME                Credit Suisse AG, Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL
NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE DATA:                F#586238 Filed with: NC—Secretary of State; Debtor: ADDISON WHITNEY LLC CM: 21076/009
A#938138     FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212)
450-6018                B. E-MAIL CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] 20170080207J 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. X ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8    4. CONTINUATION: Effectiveness of the Financing Statement identified above with respect to the security
interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable law                5. PARTY
INFORMATION CHANGE:                Check one of these two boxes: AND Check one of these three boxes
to:                CHANGE name and/or address: Complete ADD name: Complete item DELETE name: Give record name This Change affects Debtor or Secured Party of record item
6a or 6b; and item 7a or 7b and item 7c 7a or 7b, and item 7c to be deleted in item 6a or 6b 6. CURRENT RECORD INFORMATION: Complete for Party Information Change—provide only one name (6a or
6b)                6a. ORGANIZATION’S NAME                OR 6b. INDIVIDUAL’S
SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any
part of the Debtor’s name) 7a. ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR                7b. INDIVIDUAL’S
SURNAME                INDIVIDUAL’S FIRST PERSONAL
NAME                INDIVIDUAL’S ADDITIONAL NAME(S)/INITIAL(S)                SUFFIX
7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago IL 60603-2300 USA 8. COLLATERAL CHANGE: Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate
collateral:                9. NAME OF SECURED PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment)
If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing Debtor                9a. ORGANIZATION’S
NAME                Credit Suisse AG, Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL
NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE DATA:                F#586234 Filed with: NC—Secretary of State; Debtor: INVENTIV HEALTH CONSULTING, INC. CM:
21076/009 A#938154     FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212)
450-6018                B. E-MAIL CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] 20170080298J 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. X ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8    4. CONTINUATION: Effectiveness of the Financing Statement identified above with respect to the security
interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable law                5. PARTY
INFORMATION CHANGE:                Check one of these two boxes: AND Check one of these three boxes
to:                CHANGE name and/or address: Complete ADD name: Complete item DELETE name: Give record name This Change affects Debtor or Secured Party of record item
6a or 6b; and item 7a or 7b and item 7c 7a or 7b, and item 7c to be deleted in item 6a or 6b 6. CURRENT RECORD INFORMATION: Complete for Party Information Change—provide only one name (6a or
6b)                6a. ORGANIZATION’S NAME                OR 6b. INDIVIDUAL’S
SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any
part of the Debtor’s name) 7a. ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR                7b. INDIVIDUAL’S
SURNAME                INDIVIDUAL’S FIRST PERSONAL
NAME                INDIVIDUAL’S ADDITIONAL NAME(S)/INITIAL(S)                SUFFIX
7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago IL 60603-2300 USA 8. COLLATERAL CHANGE: Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate
collateral:                9. NAME OF SECURED PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment)
If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing Debtor                9a. ORGANIZATION’S
NAME                Credit Suisse AG, Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL
NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE DATA:                F#586235 Filed with: NC—Secretary of State; Debtor: PHARMACEUTICAL INSTITUTE, LLC CM:
21076/009 A#938161     FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212)
450-6018                B. E-MAIL CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] 52342653 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment Addendum
(Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. X ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8    4. CONTINUATION: Effectiveness of the Financing Statement identified above with respect to the security
interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable law                5. PARTY
INFORMATION CHANGE:                Check one of these two boxes: AND Check one of these three boxes
to:                CHANGE name and/or address: Complete ADD name: Complete item DELETE name: Give record name This Change affects Debtor or Secured Party of record item
6a or 6b; and item 7a or 7b and item 7c 7a or 7b, and item 7c to be deleted in item 6a or 6b 6. CURRENT RECORD INFORMATION: Complete for Party Information Change—provide only one name (6a or
6b)                6a. ORGANIZATION’S NAME                OR 6b. INDIVIDUAL’S
SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any
part of the Debtor’s name) 7a. ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR                7b. INDIVIDUAL’S
SURNAME                INDIVIDUAL’S FIRST PERSONAL
NAME                INDIVIDUAL’S ADDITIONAL NAME(S)/INITIAL(S)                SUFFIX
7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago IL 60603-2300 USA 8. COLLATERAL CHANGE: Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate
collateral:                9. NAME OF SECURED PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment)
If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing Debtor                9a. ORGANIZATION’S
NAME                Credit Suisse AG, Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL
NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE DATA:                F#586229 Filed with: NJ—Department of Treasury/Commercial Recording; Debtor: INVENTIV
COMMERCIAL SERVICES, LLC CM: 21076/009 A#938149     FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212)
450-6018                B. E-MAIL CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] 52342660 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment Addendum
(Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. X ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8    4. CONTINUATION: Effectiveness of the Financing Statement identified above with respect to the security
interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable law                5. PARTY
INFORMATION CHANGE:                Check one of these two boxes: AND Check one of these three boxes
to:                CHANGE name and/or address: Complete ADD name: Complete item DELETE name: Give record name This Change affects Debtor or Secured Party of record item
6a or 6b; and item 7a or 7b and item 7c 7a or 7b, and item 7c to be deleted in item 6a or 6b 6. CURRENT RECORD INFORMATION: Complete for Party Information Change—provide only one name (6a or
6b)                6a. ORGANIZATION’S NAME                OR 6b. INDIVIDUAL’S
SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any
part of the Debtor’s name) 7a. ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR                7b. INDIVIDUAL’S
SURNAME                INDIVIDUAL’S FIRST PERSONAL
NAME                INDIVIDUAL’S ADDITIONAL NAME(S)/INITIAL(S)                SUFFIX
7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago IL 60603-2300 USA 8. COLLATERAL CHANGE: Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate
collateral:                9. NAME OF SECURED PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment)
If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing Debtor                9a. ORGANIZATION’S
NAME                Credit Suisse AG, Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL
NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE DATA:                F#586230 Filed with: NJ—Department of Treasury/Commercial Recording; Debtor: INVENTIV
HEALTH CLINICAL LAB, INC. CM: 21076/009 A#938151     FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS (2_#_% a__ bac5) CAREFULLY                A. NAME & PHONE OF CONTACT AT FILER
[#$%&#_a’]                Christian Craft (212)
450-6018                B. SEND ACKNOWLEDGMENT TO: (Na__ a__
A______)                Davis Polk & Wardwell LLP                450 Lexington
Avenue                New York, NY
10017                christian.craft@davispolk.com                 THE ABOVE SPACE IS FOR
FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE #                1b. T___ FINANCING STATEMENT AMENDMENT __ 201708010374626
08/01/2017                __ b_ _____ [___ __c___] (__ __c_____) _
___                REAL ESTATE RECORDS. 2. TERMINATION: E___c__/_ ___ __ ___ F_ a c_ + S_a__&_ _ ___ ______ ab_/_ __ ___&_ a___ 1___ ___,_c_ __ __c*___- _
______(_) __ ___ S_c*___ Pa__- a*_____?_ + ____ T__&_ a___ S_a__&_ _. 3. CONTINUATION: E___c__/_ ___ __ ___ F_ a c_ + S_a__&_ _ ___ ______ ab_/_ 1___ ___,_c_ __ __c*___- _ ______(_) __ ___ S_c*___ Pa__- a*_____?_ + ____ C_ __ *a___
S_a__&_ _ __ c_ __ *__ ___ ___ a______ a_ ,_____ ,__/____ b- a,,__cab__ _a1.                4. X ASSIGNMENT (_*__ __
,a___a_): G_/_ a&_ __ a___+ __ _ ___& 7a __ 7b a _ a______ __ a___+ __ _ ___& 7c; a _ a___ +_/_ a&_ __ a___+ __ _ ___& 9. 5. AMENDMENT (PARTY INFORMATION): T___ A&_ _&_ _ a___c__ D_b___ __ S_c*___ Pa__- __ __c___. C__c0 _
_- _ _ __ _____ _1_ b_2__.    A___ c__c0 _ _ __ ___ _____1_ + _____ b_2__ a _ ,__/___ a,,__,__a__ _ ___&a___ _ ___&_ 6 a _/__
7.                CHANGE a&_ a _/__ a______: P__a__ _____ __ ___ ___a____ _ ___*c___ _ DELETE a&_: G_/_ __c___ a&_ ADD a&_: C_&,____ ___& 7a __
7b, a _ a___ ___& 7c; _ __+a___ __ c_a +_ + ___ a&_/a______ __ a ,a__-. __ b_ _______ _ ___& 6a __ 6b. a___ c_&,____ ___&_ 7_-7+ (__ a,,__cab__). 6. CURRENT RECORD
INFORMATION:                6a. ORGANIZATION’S NAME                OR 6b.
INDIVIDUAL’S LAST NAME    FIRST NAME    MIDDLE NAME SUFFIX 7. CHANGED (NEW) OR ADDED INFORMATION:                7a.
ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR 7b. INDIVIDUAL’S LAST NAME    FIRST NAME    MIDDLE NAME SUFFIX 7c. MAILING
ADDRESS    CITY    STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago    IL 60603-2300 USA 7_. SEE INSTRUCTIONS ADD’L INFO RE 7_. TYPE OF ORGANIZATION 7_. JURISDICTION OF
ORGANIZATION 7+. ORGANIZATIONAL ID #, __ a—
ORGANIZATION                DEBTOR                NONE 8. AMENDMENT (COLLATERAL CHANGE):
c__c0 _ _- _ _ b_2.                D__c__b_ c___a___a_ _______ __ a____, __ +_/_ _ ____ ____a___ c___a___a_ ___c__,___ , __ ___c__b_ c___a___a_ a___+
__.    9. NAME OF SECURED PARTY OF RECORD AUTHORIZING THIS AMENDMENT ( a&_ __ a___+ __, __ ____ __ a A___+ &_ _). I_ ____ __ a A&_ _&_ _ a*_____?__ b- a D_b___ 1__c_ a___
c___a___a_ __ a___ ___ a*_____?_ + D_b___, __ __ ____ __ a T__&_ a___ a*_____?__ b- a D_b___, c__c0 ____ a _ _ ___ a&_ __ DEBTOR a*_____?_ + ____ A&_ _&_ _.    9a.
ORGANIZATION’S NAME                Credit Suisse AG, Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S LAST
NAME    FIRST NAME    MIDDLE NAME SUFFIX 10.OPTIONAL FILER REFERENCE DATA                F#586241 Filed with: NY—Secretary
of State; Debtor: BIOSECTOR 2 LLC CM: 21076/009 A#938141 FILING OFFICE COPY    UCC FINANCING STATEMENT AMENDMENT (FORM UCC3) (REV. 05/22/02) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS (2_#_% a__ bac5) CAREFULLY                A. NAME & PHONE OF CONTACT AT FILER
[#$%&#_a’]                Christian Craft (212)
450-6018                B. SEND ACKNOWLEDGMENT TO: (Na__ a__
A______)                Davis Polk & Wardwell LLP                450 Lexington
Avenue                New York, NY
10017                christian.craft@davispolk.com                THE ABOVE SPACE IS FOR
FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE #                1b. T___ FINANCING STATEMENT AMENDMENT __ 201708010374575
08/01/2017                __ b_ _____ [___ __c___] (__ __c_____) _
___                REAL ESTATE RECORDS. 2. TERMINATION: E___c__/_ ___ __ ___ F_ a c_ + S_a__&_ _ ___ ______ ab_/_ __ ___&_ a___ 1___ ___,_c_ __ __c*___- _
______(_) __ ___ S_c*___ Pa__- a*_____?_ + ____ T__&_ a___ S_a__&_ _. 3. CONTINUATION: E___c__/_ ___ __ ___ F_ a c_ + S_a__&_ _ ___ ______ ab_/_ 1___ ___,_c_ __ __c*___- _ ______(_) __ ___ S_c*___ Pa__- a*_____?_ + ____ C_ __ *a___
S_a__&_ _ __ c_ __ *__ ___ ___ a______ a_ ,_____ ,__/____ b- a,,__cab__ _a1.                4. X ASSIGNMENT (_*__ __
,a___a_): G_/_ a&_ __ a___+ __ _ ___& 7a __ 7b a _ a______ __ a___+ __ _ ___& 7c; a _ a___ +_/_ a&_ __ a___+ __ _ ___& 9.    5. AMENDMENT (PARTY INFORMATION): T___ A&_ _&_ _ a___c__ D_b___ __ S_c*___
Pa__- __ __c___. C__c0 _ _- _ _ __ _____ _1_ b_2__.    A___ c__c0 _ _ __ ___ _____1_ + _____ b_2__ a _ ,__/___ a,,__,__a__ _ ___&a___ _ ___&_ 6 a _/__
7.                CHANGE a&_ a _/__ a______: P__a__ _____ __ ___ ___a____ _ ___*c___ _ DELETE a&_: G_/_ __c___ a&_ ADD a&_: C_&,____ ___& 7a __
7b, a _ a___ ___& 7c; _ __+a___ __ c_a +_ + ___ a&_/a______ __ a ,a__-. __ b_ _______ _ ___& 6a __ 6b. a___ c_&,____ ___&_ 7_-7+ (__ a,,__cab__). 6. CURRENT RECORD
INFORMATION:                6a. ORGANIZATION’S NAME                OR 6b.
INDIVIDUAL’S LAST NAME    FIRST NAME    MIDDLE NAME SUFFIX 7. CHANGED (NEW) OR ADDED INFORMATION:                7a.
ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR 7b. INDIVIDUAL’S LAST NAME    FIRST NAME    MIDDLE NAME SUFFIX 7c. MAILING
ADDRESS    CITY    STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago    IL 60603-2300 USA 7_. SEE INSTRUCTIONS ADD’L INFO RE 7_. TYPE OF ORGANIZATION 7_. JURISDICTION OF
ORGANIZATION 7+. ORGANIZATIONAL ID #, __ a—
ORGANIZATION                DEBTOR                NONE 8. AMENDMENT (COLLATERAL CHANGE):
c__c0 _ _- _ _ b_2.                D__c__b_ c___a___a_ _______ __ a____, __ +_/_ _ ____ ____a___ c___a___a_ ___c__,___ , __ ___c__b_ c___a___a_ a___+
__.    9. NAME OF SECURED PARTY OF RECORD AUTHORIZING THIS AMENDMENT ( a&_ __ a___+ __, __ ____ __ a A___+ &_ _). I_ ____ __ a A&_ _&_ _ a*_____?__ b- a D_b___ 1__c_ a___
c___a___a_ __ a___ ___ a*_____?_ + D_b___, __ __ ____ __ a T__&_ a___ a*_____?__ b- a D_b___, c__c0 ____ a _ _ ___ a&_ __ DEBTOR a*_____?_ + ____ A&_ _&_ _.    9a.
ORGANIZATION’S NAME                Credit Suisse AG, Cayman Islands Branch, as Collateral
Agent                OR 9b. INDIVIDUAL’S LAST NAME    FIRST NAME    MIDDLE NAME SUFFIX 10.OPTIONAL FILER REFERENCE
DATA                F#586225 Filed with: NY—Secretary of State; Debtor: CHANDLER CHICCO AGENCY, L.L.C. CM: 21076/009 A#938145 FILING OFFICE
COPY    UCC FINANCING STATEMENT AMENDMENT (FORM UCC3) (REV. 05/22/02) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS (2_#_% a__ bac5) CAREFULLY                A. NAME & PHONE OF CONTACT AT FILER
[#$%&#_a’]                Christian Craft (212)
450-6018                B. SEND ACKNOWLEDGMENT TO: (Na__ a__
A______)                Davis Polk & Wardwell LLP                450 Lexington
Avenue                New York, NY
10017                christian.craft@davispolk.com                THE ABOVE SPACE IS FOR
FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE #                1b. T___ FINANCING STATEMENT AMENDMENT __ 201708010374640
08/01/2017                __ b_ _____ [___ __c___] (__ __c_____) _
___                REAL ESTATE RECORDS. 2. TERMINATION: E___c__/_ ___ __ ___ F_ a c_ + S_a__&_ _ ___ ______ ab_/_ __ ___&_ a___ 1___ ___,_c_ __ __c*___- _
______(_) __ ___ S_c*___ Pa__- a*_____?_ + ____ T__&_ a___ S_a__&_ _. 3. CONTINUATION: E___c__/_ ___ __ ___ F_ a c_ + S_a__&_ _ ___ ______ ab_/_ 1___ ___,_c_ __ __c*___- _ ______(_) __ ___ S_c*___ Pa__- a*_____?_ + ____ C_ __ *a___
S_a__&_ _ __ c_ __ *__ ___ ___ a______ a_ ,_____ ,__/____ b- a,,__cab__ _a1.                4. X ASSIGNMENT (_*__ __
,a___a_): G_/_ a&_ __ a___+ __ _ ___& 7a __ 7b a _ a______ __ a___+ __ _ ___& 7c; a _ a___ +_/_ a&_ __ a___+ __ _ ___& 9.    5. AMENDMENT (PARTY INFORMATION): T___ A&_ _&_ _ a___c__ D_b___ __ S_c*___
Pa__- __ __c___. C__c0 _ _- _ _ __ _____ _1_ b_2__.    A___ c__c0 _ _ __ ___ _____1_ + _____ b_2__ a _ ,__/___ a,,__,__a__ _ ___&a___ _ ___&_ 6 a _/__
7.                CHANGE a&_ a _/__ a______: P__a__ _____ __ ___ ___a____ _ ___*c___ _ DELETE a&_: G_/_ __c___ a&_ ADD a&_: C_&,____ ___& 7a __
7b, a _ a___ ___& 7c; _ __+a___ __ c_a +_ + ___ a&_/a______ __ a ,a__-. __ b_ _______ _ ___& 6a __ 6b. a___ c_&,____ ___&_ 7_-7+ (__ a,,__cab__). 6. CURRENT RECORD
INFORMATION:                6a. ORGANIZATION’S NAME                OR 6b.
INDIVIDUAL’S LAST NAME    FIRST NAME    MIDDLE NAME SUFFIX 7. CHANGED (NEW) OR ADDED INFORMATION:                7a.
ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR 7b. INDIVIDUAL’S LAST NAME    FIRST NAME    MIDDLE NAME SUFFIX 7c. MAILING
ADDRESS    CITY    STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago    IL 60603-2300 USA 7_. SEE INSTRUCTIONS ADD’L INFO RE 7_. TYPE OF ORGANIZATION 7_. JURISDICTION OF
ORGANIZATION 7+. ORGANIZATIONAL ID #, __ a—
ORGANIZATION                DEBTOR                NONE 8. AMENDMENT (COLLATERAL CHANGE):
c__c0 _ _- _ _ b_2.                D__c__b_ c___a___a_ _______ __ a____, __ +_/_ _ ____ ____a___ c___a___a_ ___c__,___ , __ ___c__b_ c___a___a_ a___+
__.    9. NAME OF SECURED PARTY OF RECORD AUTHORIZING THIS AMENDMENT ( a&_ __ a___+ __, __ ____ __ a A___+ &_ _). I_ ____ __ a A&_ _&_ _ a*_____?__ b- a D_b___ 1__c_ a___
c___a___a_ __ a___ ___ a*_____?_ + D_b___, __ __ ____ __ a T__&_ a___ a*_____?__ b- a D_b___, c__c0 ____ a _ _ ___ a&_ __ DEBTOR a*_____?_ + ____ A&_ _&_ _.    9a.
ORGANIZATION’S NAME                Credit Suisse AG, Cayman Islands Branch, as Collateral
Agent                OR 9b. INDIVIDUAL’S LAST NAME    FIRST NAME    MIDDLE NAME SUFFIX 10.OPTIONAL FILER REFERENCE
DATA                F#586227 Filed with: NY—Secretary of State; Debtor: LITMUS MEDICAL MARKETING SERVICES LLC CM: 21076/009 A#938158 FILING OFFICE
COPY    UCC FINANCING STATEMENT AMENDMENT (FORM UCC3) (REV. 05/22/02) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212)
450-6018                B. E-MAIL CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] OH00213814214 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. X ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8    4. CONTINUATION: Effectiveness of the Financing Statement identified above with respect to the security
interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable law                5. PARTY
INFORMATION CHANGE:                Check one of these two boxes: AND Check one of these three boxes
to:                CHANGE name and/or address: Complete ADD name: Complete item DELETE name: Give record name This Change affects Debtor or Secured Party of record item
6a or 6b; and item 7a or 7b and item 7c 7a or 7b, and item 7c to be deleted in item 6a or 6b 6. CURRENT RECORD INFORMATION: Complete for Party Information Change—provide only one name (6a or
6b)                6a. ORGANIZATION’S NAME                OR 6b. INDIVIDUAL’S
SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any
part of the Debtor’s name) 7a. ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR 7b. INDIVIDUAL’S SURNAME                INDIVIDUAL’S
FIRST PERSONAL NAME                INDIVIDUAL’S ADDITIONAL
NAME(S)/INITIAL(S)                SUFFIX 7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago IL 60603-2300 USA 8. COLLATERAL CHANGE:
Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate collateral:                9. NAME OF SECURED
PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment) If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing
Debtor                9a. ORGANIZATION’S NAME                Credit Suisse AG,
Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE
DATA:                F#586216 Filed with: OH—Secretary of State; Debtor: INVENTIV HEALTH COMMUNICATIONS, INC. CM: 21076/009
A#938137    -RXIVREXMSREP %WWSGMEXMSR SJ ‘SQQIVGMEP %HQMRMWXVEXSVW _-%’% FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212)
450-6018                B. E-MAIL CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] OH00213814325 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. X ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8    4. CONTINUATION: Effectiveness of the Financing Statement identified above with respect to the security
interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable law                5. PARTY
INFORMATION CHANGE:                Check one of these two boxes: AND Check one of these three boxes
to:                CHANGE name and/or address: Complete ADD name: Complete item DELETE name: Give record name This Change affects Debtor or Secured Party of record item
6a or 6b; and item 7a or 7b and item 7c 7a or 7b, and item 7c to be deleted in item 6a or 6b 6. CURRENT RECORD INFORMATION: Complete for Party Information Change—provide only one name (6a or
6b)                6a. ORGANIZATION’S NAME                OR 6b. INDIVIDUAL’S
SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any
part of the Debtor’s name) 7a. ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR 7b. INDIVIDUAL’S SURNAME                INDIVIDUAL’S
FIRST PERSONAL NAME                INDIVIDUAL’S ADDITIONAL
NAME(S)/INITIAL(S)                SUFFIX 7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago IL 60603-2300 USA 8. COLLATERAL CHANGE:
Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate collateral:                9. NAME OF SECURED
PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment) If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing
Debtor                9a. ORGANIZATION’S NAME                Credit Suisse AG,
Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE
DATA:                F#586219 Filed with: OH—Secretary of State; Debtor: CADENT MEDICAL COMMUNICATIONS, LLC CM: 21076-009
A#938143    -RXIVREXMSREP %WWSGMEXMSR SJ ‘SQQIVGMEP %HQMRMWXVEXSVW _-%’% FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212)
450-6018                B. E-MAIL CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] OH00213814547 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. X ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8    4. CONTINUATION: Effectiveness of the Financing Statement identified above with respect to the security
interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable law                5. PARTY
INFORMATION CHANGE:                Check one of these two boxes: AND Check one of these three boxes
to:                CHANGE name and/or address: Complete ADD name: Complete item DELETE name: Give record name This Change affects Debtor or Secured Party of record item
6a or 6b; and item 7a or 7b and item 7c 7a or 7b, and item 7c to be deleted in item 6a or 6b 6. CURRENT RECORD INFORMATION: Complete for Party Information Change—provide only one name (6a or
6b)                6a. ORGANIZATION’S NAME                OR 6b. INDIVIDUAL’S
SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any
part of the Debtor’s name) 7a. ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR 7b. INDIVIDUAL’S SURNAME                INDIVIDUAL’S
FIRST PERSONAL NAME                INDIVIDUAL’S ADDITIONAL
NAME(S)/INITIAL(S)                SUFFIX 7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago IL 60603-2300 USA 8. COLLATERAL CHANGE:
Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate collateral:                9. NAME OF SECURED
PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment) If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing
Debtor                9a. ORGANIZATION’S NAME                Credit Suisse AG,
Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE
DATA:                F#586220 Filed with: OH—Secretary of State; Debtor: GERBIG, SNELL/WEISHEIMER ADVERTISING, LLC CM: 21076/009
A#938146    -RXIVREXMSREP %WWSGMEXMSR SJ ‘SQQIVGMEP %HQMRMWXVEXSVW _-%’% FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212)
450-6018                B. E-MAIL CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] OH00213814870 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. X ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8    4. CONTINUATION: Effectiveness of the Financing Statement identified above with respect to the security
interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable law                5. PARTY
INFORMATION CHANGE:                Check one of these two boxes: AND Check one of these three boxes
to:                CHANGE name and/or address: Complete ADD name: Complete item DELETE name: Give record name This Change affects Debtor or Secured Party of record item
6a or 6b; and item 7a or 7b and item 7c 7a or 7b, and item 7c to be deleted in item 6a or 6b 6. CURRENT RECORD INFORMATION: Complete for Party Information Change—provide only one name (6a or
6b)                6a. ORGANIZATION’S NAME                OR 6b. INDIVIDUAL’S
SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any
part of the Debtor’s name) 7a. ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR 7b. INDIVIDUAL’S SURNAME                INDIVIDUAL’S
FIRST PERSONAL NAME                INDIVIDUAL’S ADDITIONAL
NAME(S)/INITIAL(S)                SUFFIX 7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago IL 60603-2300 USA 8. COLLATERAL CHANGE:
Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate collateral:                9. NAME OF SECURED
PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment) If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing
Debtor                9a. ORGANIZATION’S NAME                Credit Suisse AG,
Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE
DATA:                F#586221 Filed with: OH—Secretary of State; Debtor: INVENTIV MEDICAL COMMUNICATIONS, LLC CM: 21076/009
A#938157    -RXIVREXMSREP %WWSGMEXMSR SJ ‘SQQIVGMEP %HQMRMWXVEXSVW _-%’% FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212)
450-6018                B. E-MAIL CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] OH00213814981 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. X ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8    4. CONTINUATION: Effectiveness of the Financing Statement identified above with respect to the security
interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable law                5. PARTY
INFORMATION CHANGE:                Check one of these two boxes: AND Check one of these three boxes
to:                CHANGE name and/or address: Complete ADD name: Complete item DELETE name: Give record name This Change affects Debtor or Secured Party of record item
6a or 6b; and item 7a or 7b and item 7c 7a or 7b, and item 7c to be deleted in item 6a or 6b 6. CURRENT RECORD INFORMATION: Complete for Party Information Change—provide only one name (6a or
6b)                6a. ORGANIZATION’S NAME                OR 6b. INDIVIDUAL’S
SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any
part of the Debtor’s name) 7a. ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR 7b. INDIVIDUAL’S SURNAME                INDIVIDUAL’S
FIRST PERSONAL NAME                INDIVIDUAL’S ADDITIONAL
NAME(S)/INITIAL(S)                SUFFIX 7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago IL 60603-2300 USA 8. COLLATERAL CHANGE:
Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate collateral:                9. NAME OF SECURED
PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment) If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing
Debtor                9a. ORGANIZATION’S NAME                Credit Suisse AG,
Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE
DATA:                F#586222 Filed with: OH—Secretary of State; Debtor: NAVICOR GROUP, LLC CM: 21076/009 A#938159    -RXIVREXMSREP %WWSGMEXMSR
SJ ‘SQQIVGMEP %HQMRMWXVEXSVW _-%’% FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212)
450-6018                B. E-MAIL CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] OH00213814092 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. X ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8    4. CONTINUATION: Effectiveness of the Financing Statement identified above with respect to the security
interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable law                5. PARTY
INFORMATION CHANGE:                Check one of these two boxes: AND Check one of these three boxes
to:                CHANGE name and/or address: Complete ADD name: Complete item DELETE name: Give record name This Change affects Debtor or Secured Party of record item
6a or 6b; and item 7a or 7b and item 7c 7a or 7b, and item 7c to be deleted in item 6a or 6b 6. CURRENT RECORD INFORMATION: Complete for Party Information Change—provide only one name (6a or
6b)                6a. ORGANIZATION’S NAME                OR 6b. INDIVIDUAL’S
SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any
part of the Debtor’s name) 7a. ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR 7b. INDIVIDUAL’S SURNAME                INDIVIDUAL’S
FIRST PERSONAL NAME                INDIVIDUAL’S ADDITIONAL
NAME(S)/INITIAL(S)                SUFFIX 7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago IL 60603-2300 USA 8. COLLATERAL CHANGE:
Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate collateral:                9. NAME OF SECURED
PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment) If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing
Debtor                9a. ORGANIZATION’S NAME                Credit Suisse AG,
Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE
DATA:                F#586198 Filed with: OH—Secretary of State; Debtor: PALIO + IGNITE, LLC CM: 21076-009
A#938160    -RXIVREXMSREP %WWSGMEXMSR SJ ‘SQQIVGMEP %HQMRMWXVEXSVW _-%’% FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212)
450-6018                B. E-MAIL CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] OH00213816127 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. X ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8    4. CONTINUATION: Effectiveness of the Financing Statement identified above with respect to the security
interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable law                5. PARTY
INFORMATION CHANGE:                Check one of these two boxes: AND Check one of these three boxes
to:                CHANGE name and/or address: Complete ADD name: Complete item DELETE name: Give record name This Change affects Debtor or Secured Party of record item
6a or 6b; and item 7a or 7b and item 7c 7a or 7b, and item 7c to be deleted in item 6a or 6b 6. CURRENT RECORD INFORMATION: Complete for Party Information Change—provide only one name (6a or
6b)                6a. ORGANIZATION’S NAME                OR 6b. INDIVIDUAL’S
SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any
part of the Debtor’s name) 7a. ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR 7b. INDIVIDUAL’S SURNAME                INDIVIDUAL’S
FIRST PERSONAL NAME                INDIVIDUAL’S ADDITIONAL
NAME(S)/INITIAL(S)                SUFFIX 7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago IL 60603-2300 USA 8. COLLATERAL CHANGE:
Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate collateral:                9. NAME OF SECURED
PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment) If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing
Debtor                9a. ORGANIZATION’S NAME                Credit Suisse AG,
Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE
DATA:                F#586243 Filed with: OH—Secretary of State; Debtor: THE SELVA GROUP, LLC CM: 21076/009 A#938162    -RXIVREXMSREP
%WWSGMEXMSR SJ ‘SQQIVGMEP %HQMRMWXVEXSVW _-%’% FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212)
450-6018                B. E-MAIL CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] OH00213816450 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. X ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8    4. CONTINUATION: Effectiveness of the Financing Statement identified above with respect to the security
interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable law                5. PARTY
INFORMATION CHANGE:                Check one of these two boxes: AND Check one of these three boxes
to:                CHANGE name and/or address: Complete ADD name: Complete item DELETE name: Give record name This Change affects Debtor or Secured Party of record item
6a or 6b; and item 7a or 7b and item 7c 7a or 7b, and item 7c to be deleted in item 6a or 6b 6. CURRENT RECORD INFORMATION: Complete for Party Information Change—provide only one name (6a or
6b)                6a. ORGANIZATION’S NAME                OR 6b. INDIVIDUAL’S
SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any
part of the Debtor’s name) 7a. ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR 7b. INDIVIDUAL’S SURNAME                INDIVIDUAL’S
FIRST PERSONAL NAME                INDIVIDUAL’S ADDITIONAL
NAME(S)/INITIAL(S)                SUFFIX 7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago IL 60603-2300 USA 8. COLLATERAL CHANGE:
Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate collateral:                9. NAME OF SECURED
PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment) If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing
Debtor                9a. ORGANIZATION’S NAME                Credit Suisse AG,
Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE
DATA:                F#586247 Filed with: OH—Secretary of State; Debtor: KENDLE AMERICAS INVESTMENT INC. CM: 21076/009 A#938163    -RXIVREXMSREP
%WWSGMEXMSR SJ ‘SQQIVGMEP %HQMRMWXVEXSVW _-%’% FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212)
450-6018                B. E-MAIL CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] OH00213816672 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. X ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8                4. CONTINUATION: Effectiveness of
the Financing Statement identified above with respect to the security interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable
law                5. PARTY INFORMATION CHANGE:                Check one of these two
boxes: AND Check one of these three boxes to:                CHANGE name and/or address: Complete ADD name: Complete item DELETE name: Give record name This Change
affects Debtor or Secured Party of record item 6a or 6b; and item 7a or 7b and item 7c 7a or 7b, and item 7c to be deleted in item 6a or 6b 6. CURRENT RECORD INFORMATION: Complete for Party Information Change—provide only one name (6a or
6b)                6a. ORGANIZATION’S NAME                OR 6b. INDIVIDUAL’S
SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any
part of the Debtor’s name) 7a. ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR 7b. INDIVIDUAL’S SURNAME                INDIVIDUAL’S
FIRST PERSONAL NAME                INDIVIDUAL’S ADDITIONAL
NAME(S)/INITIAL(S)                SUFFIX 7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago IL 60603-2300 USA 8. COLLATERAL CHANGE:
Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate collateral:                9. NAME OF SECURED
PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment) If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing
Debtor                9a. ORGANIZATION’S NAME                Credit Suisse AG,
Cayman Islands Branch, as Collateral Agent                OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER
REFERENCE DATA:                F#586248 Filed with: OH—Secretary of State; Debtor: KENDLE AMERICAS MANAGEMENT INC. CM: 21076/009
A#938164    -RXIVREXMSREP %WWSGMEXMSR SJ ‘SQQIVGMEP %HQMRMWXVEXSVW _-%’% FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Sonya Jackman (212)
450-4106                B. E-MAIL CONTACT AT FILER
(optional)                sonya.jackman@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] 2017 5090219 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8    4. CONTINUATION: Effectiveness of the Financing Statement identified above with respect to the security
interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable law                5. X PARTY
INFORMATION CHANGE:                Check one of these two boxes: AND Check one of these three boxes
to:                This Change affects X Debtor or Secured Party of record X item CHANGE 6a or name 6b; and and/or item address: 7a or 7b and Complete item 7c 7a ADD or
name: 7b, and Complete item 7c item to DELETE be deleted name: in item Give 6a record or 6b name 6. CURRENT RECORD INFORMATION: Complete for Party Information Change—provide only one name (6a or 6b)    6a.
ORGANIZATION’S NAME                INC Research Holdings, Inc.                OR 6b.
INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify,
or abbreviate any part of the Debtor’s name) 7a. ORGANIZATION’S NAME                Syneos Health,
Inc.                OR 7b. INDIVIDUAL’S SURNAME                INDIVIDUAL’S
FIRST PERSONAL NAME                INDIVIDUAL’S ADDITIONAL
NAME(S)/INITIAL(S)                SUFFIX 7c. MAILING ADDRESS CITY    STATE POSTAL CODE COUNTRY _____6\QF_6WUHHW_____6\QF_6WUHHW
0RUULVYLOOH0RUULVYLOOH NCNC 27___27___ USA 8. COLLATERAL CHANGE: Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate
collateral:                9. NAME OF SECURED PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment)
If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing Debtor                9a. ORGANIZATION’S
NAME                Credit Suisse AG, Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL
NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE DATA:                F#586245 Filed with: DE—Secretary of State; Debtor: INC RESEARCH HOLDINGS, INC. CM:
21076/009 A#846231    -RXIVREXMSREP %WWSGMEXMSR SJ ‘SQQIVGMEP %HQMRMWXVEXSVW _-%’% FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212)
450-6018                B. E-MAIL CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] 2017 5090219 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. X ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8    4. CONTINUATION: Effectiveness of the Financing Statement identified above with respect to the security
interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable law                5. PARTY
INFORMATION CHANGE:                Check one of these two boxes: AND Check one of these three boxes
to:                CHANGE name and/or address: Complete ADD name: Complete item DELETE name: Give record name This Change affects Debtor or Secured Party of record item
6a or 6b; and item 7a or 7b and item 7c 7a or 7b, and item 7c to be deleted in item 6a or 6b 6. CURRENT RECORD INFORMATION: Complete for Party Information Change—provide only one name (6a or
6b)                6a. ORGANIZATION’S NAME                OR 6b. INDIVIDUAL’S
SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any
part of the Debtor’s name) 7a. ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR 7b. INDIVIDUAL’S SURNAME                INDIVIDUAL’S
FIRST PERSONAL NAME                INDIVIDUAL’S ADDITIONAL
NAME(S)/INITIAL(S)                SUFFIX 7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago IL 60603-2300 USA 8. COLLATERAL CHANGE:
Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate collateral:                9. NAME OF SECURED
PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment) If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing
Debtor                9a. ORGANIZATION’S NAME                Credit Suisse AG,
Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE
DATA:                F#586245 Filed with: DE—Secretary of State; Debtor: Syneos Health, Inc. CM: 21076/009 A#938273    -RXIVREXMSREP %WWSGMEXMSR
SJ ‘SQQIVGMEP %HQMRMWXVEXSVW _-%’% FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT    FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212) 450-6018    B. E-MAIL
CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] 2017 5089617 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8    4. CONTINUATION: Effectiveness of the Financing Statement identified above with respect to the security
interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable law                5. X PARTY
INFORMATION CHANGE:                Check one of these two boxes: AND Check one of these three boxes to:    This Change affects X Debtor or Secured
Party of record X item CHANGE 6a or name 6b; and and/or item address: 7a or 7b and Complete item 7c 7a ADD or name: 7b, and Complete item 7c item to DELETE be deleted name: in item Give 6a record or 6b name 6. CURRENT RECORD INFORMATION: Complete
for Party Information Change—provide only one name (6a or 6b)    6a. ORGANIZATION’S NAME                inVentiv Health,
Inc.                OR 6b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or
Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any part of the Debtor’s name) 7a. ORGANIZATION’S
NAME                SYNEOS HEALTH US, INC.                OR 7b. INDIVIDUAL’S
SURNAME                INDIVIDUAL’S FIRST PERSONAL
NAME                INDIVIDUAL’S ADDITIONAL NAME(S)/INITIAL(S)                SUFFIX
7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY Independence Wharf, 470 Atlantic Avenue, 11th Floor Boston MA 10010 USA 8. COLLATERAL CHANGE: Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN
collateral Indicate collateral:                9. NAME OF SECURED PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this
is an Assignment) If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing Debtor    9a. ORGANIZATION’S
NAME                Credit Suisse AG, Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL
NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE DATA:    F#586201 Filed with: DE—Secretary of State; Debtor: INVENTIV HEALTH, INC. CM: 21076/009 A#938314    -RXIVREXMSREP %WWSGMEXMSR SJ
‘SQQIVGMEP %HQMRMWXVEXSVW _-%’% FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212)
450-6018                B. E-MAIL CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] 2017 5089617 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. X ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8    4. CONTINUATION: Effectiveness of the Financing Statement identified above with respect to the security
interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable law                5. PARTY
INFORMATION CHANGE:                Check one of these two boxes: AND Check one of these three boxes
to:                CHANGE name and/or address: Complete ADD name: Complete item DELETE name: Give record name This Change affects Debtor or Secured Party of record item
6a or 6b; and item 7a or 7b and item 7c 7a or 7b, and item 7c to be deleted in item 6a or 6b 6. CURRENT RECORD INFORMATION: Complete for Party Information Change—provide only one name (6a or
6b)                6a. ORGANIZATION’S NAME                OR 6b. INDIVIDUAL’S
SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any
part of the Debtor’s name) 7a. ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR 7b. INDIVIDUAL’S SURNAME                INDIVIDUAL’S
FIRST PERSONAL NAME                INDIVIDUAL’S ADDITIONAL
NAME(S)/INITIAL(S)                SUFFIX 7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago IL 60603-2300 USA 8. COLLATERAL CHANGE:
Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate collateral:                9. NAME OF SECURED
PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment) If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing
Debtor                9a. ORGANIZATION’S NAME                Credit Suisse AG,
Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE
DATA:                F#586201 Filed with: DE—Secretary of State; Debtor: Syneos Health U6, Inc. CM: 21076/009 A#938277    -RXIVREXMSREP
%WWSGMEXMSR SJ ‘SQQIVGMEP %HQMRMWXVEXSVW _-%’% FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft    (212)
450-6018                B. E-MAIL CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] 2017 5090102 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8    4. CONTINUATION: Effectiveness of the Financing Statement identified above with respect to the security
interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable law                5. X PARTY
INFORMATION CHANGE:                Check one of these two boxes: AND Check one of these three boxes
to:                This Change affects X Debtor or Secured Party of record X item CHANGE 6a or name 6b; and and/or item address: 7a or 7b and Complete item 7c 7a ADD or
name: 7b, and Complete item 7c item to DELETE be deleted name: in item Give 6a record or 6b name 6. CURRENT RECORD INFORMATION: Complete for Party Information Change—provide only one name (6a or 6b)    6a.
ORGANIZATION’S NAME                PHARMA HOLDINGS, INC.                OR 6b.
INDIVIDUAL’S SURNAME    FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or Party Information Change—provide only one name (7a or 7b) (use exact, full
name; do not omit, modify, or abbreviate any part of the Debtor’s name) 7a. ORGANIZATION’S NAME                SYNEOS HEALTH HOLDINGS,
INC.                OR 7b. INDIVIDUAL’S SURNAME                INDIVIDUAL’S
FIRST PERSONAL NAME                INDIVIDUAL’S ADDITIONAL
NAME(S)/INITIAL(S)                SUFFIX 7c. MAILING ADDRESS    CITY    STATE POSTAL CODE COUNTRY 500 Atrium Drive, Suite 500
Somerset NJ 08873 USA 8. COLLATERAL CHANGE: Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate
collateral:                9. NAME OF SECURED PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment)
If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing Debtor                9a. ORGANIZATION’S
NAME                Credit Suisse AG, Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S SURNAME    FIRST
PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE DATA:                F#586215 Filed with: DE—Secretary of State; Debtor: PHARMA
HOLDINGS, INC. CM: 21076/009 A#938315                -RXIVREXMSREP %WWSGMEXMSR SJ ‘SQQIVGMEP %HQMRMWXVEXSVW _-%’% FILING OFFICE COPY — UCC FINANCING
STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212)
450-6018                B. E-MAIL CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] 2017 5090102 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. X ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8                4. CONTINUATION: Effectiveness of
the Financing Statement identified above with respect to the security interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable
law                5. PARTY INFORMATION CHANGE:                Check one of these two
boxes: AND Check one of these three boxes to:                CHANGE name and/or address: Complete ADD name: Complete item DELETE name: Give record name This Change
affects Debtor or Secured Party of record item 6a or 6b; and item 7a or 7b and item 7c 7a or 7b, and item 7c to be deleted in item 6a or 6b 6. CURRENT RECORD INFORMATION: Complete for Party Information Change—provide only one name (6a or
6b)                6a. ORGANIZATION’S NAME                OR 6b. INDIVIDUAL’S
SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any
part of the Debtor’s name) 7a. ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR 7b. INDIVIDUAL’S SURNAME                INDIVIDUAL’S
FIRST PERSONAL NAME                INDIVIDUAL’S ADDITIONAL
NAME(S)/INITIAL(S)                SUFFIX 7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago IL 60603-2300 USA 8. COLLATERAL CHANGE:
Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate collateral:                9. NAME OF SECURED
PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment) If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing
Debtor                9a. ORGANIZATION’S NAME                Credit Suisse AG,
Cayman Islands Branch, as Collateral Agent                OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER
REFERENCE DATA:                F#586215 Filed with: DE—Secretary of State; Debtor: Syneos Health Holdings, Inc. CM: 21076/009
A#938281    -RXIVREXMSREP %WWSGMEXMSR SJ ‘SQQIVGMEP %HQMRMWXVEXSVW _-%’% FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT    FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212) 450-6018    B. E-MAIL
CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] 2017 5090268 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8    4. CONTINUATION: Effectiveness of the Financing Statement identified above with respect to the security
interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable law                5. X PARTY
INFORMATION CHANGE:                Check one of these two boxes: AND Check one of these three boxes to:    This Change affects X Debtor or Secured
Party of record X item CHANGE 6a or name 6b; and and/or item address: 7a or 7b and Complete item 7c 7a ADD or name: 7b, and Complete item 7c item to DELETE be deleted name: in item Give 6a record or 6b name 6. CURRENT RECORD INFORMATION: Complete
for Party Information Change—provide only one name (6a or 6b)    6a. ORGANIZATION’S NAME                INC Research,
LLC                OR 6b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or
Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any part of the Debtor’s name) 7a. ORGANIZATION’S
NAME                Syneos Health, LLC                OR 7b. INDIVIDUAL’S
SURNAME                INDIVIDUAL’S FIRST PERSONAL
NAME                INDIVIDUAL’S ADDITIONAL NAME(S)/INITIAL(S)                SUFFIX
7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY _____6\QF_6WUHHW_____6\QF_6WUHHW 0RUULVYLOOH0RUULVYLOOH NCNC __________ USA 8. COLLATERAL CHANGE: Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral
ASSIGN collateral Indicate collateral:                9. NAME OF SECURED PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor,
if this is an Assignment) If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing Debtor    9a. ORGANIZATION’S
NAME                Credit Suisse AG, Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL
NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE DATA:    F#586246 Filed with: DE—Secretary of State; Debtor: INC RESEARCH, LLC CM: 21076/009 A#938317    -RXIVREXMSREP %WWSGMEXMSR SJ ‘SQQIVGMEP
%HQMRMWXVEXSVW _-%’% FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212)
450-6018                B. E-MAIL CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] 2017 5090268 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. X ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8    4. CONTINUATION: Effectiveness of the Financing Statement identified above with respect to the security
interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable law                5. PARTY
INFORMATION CHANGE:                Check one of these two boxes: AND Check one of these three boxes
to:                CHANGE name and/or address: Complete ADD name: Complete item DELETE name: Give record name This Change affects Debtor or Secured Party of record item
6a or 6b; and item 7a or 7b and item 7c 7a or 7b, and item 7c to be deleted in item 6a or 6b 6. CURRENT RECORD INFORMATION: Complete for Party Information Change—provide only one name (6a or
6b)                6a. ORGANIZATION’S NAME                OR 6b. INDIVIDUAL’S
SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any
part of the Debtor’s name) 7a. ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR 7b. INDIVIDUAL’S SURNAME                INDIVIDUAL’S
FIRST PERSONAL NAME                INDIVIDUAL’S ADDITIONAL
NAME(S)/INITIAL(S)                SUFFIX 7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago IL 60603-2300 USA 8. COLLATERAL CHANGE:
Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate collateral:                9. NAME OF SECURED
PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment) If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing
Debtor                9a. ORGANIZATION’S NAME                Credit Suisse AG,
Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE
DATA:                F#586246 Filed with: DE—Secretary of State; Debtor: Syneos Health, LLC CM: 21076/009 A#938279    -RXIVREXMSREP %WWSGMEXMSR
SJ ‘SQQIVGMEP %HQMRMWXVEXSVW _-%’% FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT    FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212) 450-6018    B. E-MAIL
CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] 2017 5089666 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8    4. CONTINUATION: Effectiveness of the Financing Statement identified above with respect to the security
interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable law                5. X PARTY
INFORMATION CHANGE:                Check one of these two boxes: AND Check one of these three boxes to:    This Change affects X Debtor or Secured
Party of record X item CHANGE 6a or name 6b; and and/or item address: 7a or 7b and Complete item 7c 7a ADD or name: 7b, and Complete item 7c item to DELETE be deleted name: in item Give 6a record or 6b name 6. CURRENT RECORD INFORMATION: Complete
for Party Information Change—provide only one name (6a or 6b)    6a. ORGANIZATION’S NAME                inVentiv Health Clinical,
Inc.                OR 6b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or
Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any part of the Debtor’s name) 7a. ORGANIZATION’S
NAME                SYNEOS HEALTH CLINICAL, INC.                OR 7b. INDIVIDUAL’S
SURNAME                INDIVIDUAL’S FIRST PERSONAL
NAME                INDIVIDUAL’S ADDITIONAL NAME(S)/INITIAL(S)                SUFFIX
7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY 500 Atrium Drive, Suite 300 Somerset NJ 08873 USA 8. COLLATERAL CHANGE: Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate
collateral:                9. NAME OF SECURED PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment)
If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing Debtor    9a. ORGANIZATION’S
NAME                Credit Suisse AG, Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL
NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE DATA:    F#586202 Filed with: DE—Secretary of State; Debtor: INVENTIV HEALTH CLINICAL, INC. CM: 21076/009 A#938316    -RXIVREXMSREP %WWSGMEXMSR SJ
‘SQQIVGMEP %HQMRMWXVEXSVW _-%’% FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212)
450-6018                B. E-MAIL CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] 2017 5089666 08/01/2017    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. X ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8    4. CONTINUATION: Effectiveness of the Financing Statement identified above with respect to the security
interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable law                5. PARTY
INFORMATION CHANGE:                Check one of these two boxes: AND Check one of these three boxes
to:                CHANGE name and/or address: Complete ADD name: Complete item DELETE name: Give record name This Change affects Debtor or Secured Party of record item
6a or 6b; and item 7a or 7b and item 7c 7a or 7b, and item 7c to be deleted in item 6a or 6b 6. CURRENT RECORD INFORMATION: Complete for Party Information Change—provide only one name (6a or
6b)                6a. ORGANIZATION’S NAME                OR 6b. INDIVIDUAL’S
SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any
part of the Debtor’s name) 7a. ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR 7b. INDIVIDUAL’S SURNAME                INDIVIDUAL’S
FIRST PERSONAL NAME                INDIVIDUAL’S ADDITIONAL
NAME(S)/INITIAL(S)                SUFFIX 7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago IL 60603-2300 USA 8. COLLATERAL CHANGE:
Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate collateral:                9. NAME OF SECURED
PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment) If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing
Debtor                9a. ORGANIZATION’S NAME                Credit Suisse AG,
Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE
DATA:                F#586202 Filed with: DE—Secretary of State; Debtor: Syneos Health Clinical, Inc. CM: 21076/009 A#938280    -RXIVREXMSREP
%WWSGMEXMSR SJ ‘SQQIVGMEP %HQMRMWXVEXSVW _-%’% FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 

 
 UCC FINANCING STATEMENT AMENDMENT                FOLLOW
INSTRUCTIONS                A. NAME & PHONE OF CONTACT AT FILER
(optional)                Christian Craft (212)
450-6018                B. E-MAIL CONTACT AT FILER
(optional)                christian.craft@davispolk.com                C. SEND
ACKNOWLEDGMENT TO: (Name and Address)                Davis Polk & Wardwell
LLP                450 Lexington Avenue                New York, NY
10017                THE ABOVE SPACE IS FOR FILING OFFICE USE ONLY 1a. INITIAL FINANCING STATEMENT FILE NUMBER    1b. This FINANCING STATEMENT
AMENDMENT is to be filed [for record] OH00220249658 04/11/2018    (or recorded) in the REAL ESTATE RECORDS                Filer: attach Amendment
Addendum (Form UCC3Ad) and provide Debtor’s name in item 13 2. TERMINATION: Effectiveness of the Financing Statement identified above is terminated with respect to the security interest(s) of Secured Party authorizing this Termination
Statement                3. X ASSIGNMENT (full or partial): Provide name of Assignee in item 7a or 7b, and address of Assignee in item 7c and name of Assignor in item
9    For partial assignment, complete items 7 and 9 and also indicate affected collateral in item 8    4. CONTINUATION: Effectiveness of the Financing Statement identified above with respect to the security
interest(s) of Secured Party authorizing this Continuation Statement is continued for the additional period provided by applicable law                5. PARTY
INFORMATION CHANGE:                Check one of these two boxes: AND Check one of these three boxes
to:                CHANGE name and/or address: Complete ADD name: Complete item DELETE name: Give record name This Change affects Debtor or Secured Party of record item
6a or 6b; and item 7a or 7b and item 7c 7a or 7b, and item 7c to be deleted in item 6a or 6b 6. CURRENT RECORD INFORMATION: Complete for Party Information Change—provide only one name (6a or
6b)                6a. ORGANIZATION’S NAME                OR 6b. INDIVIDUAL’S
SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 7. CHANGED OR ADDED INFORMATION: Complete for Assignment or Party Information Change—provide only one name (7a or 7b) (use exact, full name; do not omit, modify, or abbreviate any
part of the Debtor’s name) 7a. ORGANIZATION’S NAME                JPMorgan Chase Bank, N.A., as Collateral
Agent                OR 7b. INDIVIDUAL’S SURNAME                INDIVIDUAL’S
FIRST PERSONAL NAME                INDIVIDUAL’S ADDITIONAL
NAME(S)/INITIAL(S)                SUFFIX 7c. MAILING ADDRESS CITY STATE POSTAL CODE COUNTRY 10 South Dearborn, Floor L2 Chicago IL 60603-2300 USA 8. COLLATERAL CHANGE:
Also check one of these four boxes: ADD collateral DELETE collateral RESTATE covered collateral ASSIGN collateral Indicate collateral:                9. NAME OF SECURED
PARTY OF RECORD AUTHORIZING THIS AMENDMENT: Provide only one name (9a or 9b) (name of Assignor, if this is an Assignment) If this is an Amendment authorized by a DEBTOR, check here and provide name of authorizing
Debtor                9a. ORGANIZATION’S NAME                Credit Suisse AG,
Cayman Islands Branch, as Collateral Agent    OR 9b. INDIVIDUAL’S SURNAME FIRST PERSONAL NAME ADDITIONAL NAME(S)/INITIAL(S) SUFFIX 10. OPTIONAL FILER REFERENCE
DATA:                F#679227 Filed with: OH—Secretary of State; Debtor: TAYLOR STRATEGY PARTNERS, LLC CM: 21076/009 A#938374    -RXIVREXMSREP
%WWSGMEXMSR SJ ‘SQQIVGMEP %HQMRMWXVEXSVW _-%’% FILING OFFICE COPY — UCC FINANCING STATEMENT AMENDMENT (Form UCC3) (Rev. 04/20/11) 

 Annex A-2 

 ASSIGNMENT OF 

SECURITY INTEREST IN INTELLECTUAL PROPERTY RIGHTS 

This ASSIGNMENT OF SECURITY INTEREST IN INTELLECTUAL PROPERTY RIGHTS (“Assignment”), effective as of March [25], 2019, is
made by CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH, as Collateral Agent (in such capacity, the “Existing Agent”) and JPMORGAN CHASE BANK, N.A., as successor Collateral Agent (in such capacity, the “Successor Agent”) in
connection with (i) the Pledge and Security Agreement entered into by, among others, the grantors party thereto and the Existing Agent, dated as of August 1, 2017 (the “Closing Date Security Agreement”), (ii) the
Joinder to the Closing Date Security Agreement, entered into by Taylor Strategy Partners, LLC, dated as of March 1, 2018 (the “Joinder to the Closing Date Security Agreement” and together with the Closing Date Security
Agreement, the “Security Agreement”), (iii) the Intellectual Property Security Agreement, entered into by, among others, each Grantor party thereto from time to time (each a, “Grantor”) and the Existing Agent,
dated as of August 1, 2017 (the “Closing Date IP Security Agreement”) and (iv) the Joinder to the Closing Date IP Security Agreement entered into by Taylor Strategy Partners, LLC, dated as of March 1, 2018 (the
“Joinder to the Closing Date IP Security Agreement” and together with the Closing Date IP Security Agreement, the “IP Security Agreement”). Unless expressly provided otherwise herein, terms defined or that have
their meaning provided for in the Security Agreement or the IP Security Agreement, as applicable, shall have the same meaning when used in this Assignment (including those defined terms incorporated by reference therein). 

W I T N E S S E T H 

WHEREAS, pursuant to the Security Agreement and IP Security Agreement, each Grantor granted to the Existing Agent on behalf of and for the
ratable benefit of the Existing Agent and the Secured Parties a continuing security interest in all of such Grantor’s right, title and interest in, to and under the IP Collateral (as defined in the Closing Date IP Security Agreement or the
Joinder to the Closing Date IP Security Agreement, as applicable), including the intellectual property registrations and applications listed in Schedule A (collectively, the “Secured IP”); 

WHEREAS, the Closing Date IP Security Agreement was recorded at the United States Patent and Trademark Office on September 1, 2017 at
Reel 6145, Frame 0562 and at the United States Copyright Office on August 31, 2017 at Volume 9951, Document No. 324; 
 WHEREAS,
the Joinder to the Closing Date IP Security Agreement was filed with the United States Patent and Trademark Office on March [25], 2019; and 

WHEREAS, pursuant to the Successor Agent Agreement, dated as of the date hereof, by and among the Existing Agent and the Successor Agent,
among others (the “Successor Agency Transfer Agreement”), the Existing Agent has assigned to the Successor Agent the security interest in the Secured IP. 

NOW, THEREFORE, for good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto hereby
agree as follows: 

 SECTION 1. Assignment of Security Interest. The Existing Agent hereby assigns to the
Successor Agent each of the Liens and security interests pledged, collaterally assigned, mortgaged, transferred and granted to, or otherwise created in favor of, the Existing Agent under the Security Agreement and IP Security Agreement in, to and
under the Secured IP, and the Successor Agent hereby assumes all such Liens and security interests for the benefit of the Successor Agent and the Secured Parties. 

SECTION 2. Purpose. This Assignment has been executed and delivered by the Existing Agent and Successor Agent for the purpose of
recording the assignment of the Liens and security interests set forth herein with the United States Patent and Trademark Office and the United States Copyright Office. The Liens and security interests referred to herein are expressly subject to the
terms and conditions of the Security Agreement and IP Security Agreement as amended by the Successor Agency Transfer Agreement. The Security Agreement and IP Security Agreement as amended by the Successor Agency Transfer Agreement (and all rights
and remedies of the Secured Parties thereunder) shall remain in full force and effect in accordance with their terms. 
 SECTION 3.
Counterparts. This Assignment may be executed in counterparts, each of which will be deemed an original, but all of which together constitute one and the same original. 

[Remainder of page intentionally left blank] 

 IN WITNESS WHEREOF, the parties hereto have caused this Assignment to be duly executed and
delivered by their respective officers on the date hereof. 
  

			
	 CREDIT SUISSE AG, CAYMAN
 ISLANDS
BRANCH, as Existing Agent

		
	By:	 	 /s/ Vipul Dhadda

		 	Name: Vipul Dhadda
		 	Title: Authorized Signatory
		
	By:	 	 /s/ Joan Park

		 	Name: Joan Park
		 	Title: Authorized Signatory

 
			
	 JPMORGAN CHASE BANK, N.A.
 as
Successor Agent

		
	By:	 	 /s/ Joshn Kushnerick

		 	Name: John Kushnerick
		 	Title: Executive Director

 ACKNOWLEDGMENT OF EXISTING AGENT 

 

					
	STATE OF NEW YORK	  	)	  	
		  	) ss	  	
	COUNTY OF NEW YORK	  	)	  	

 On the 21 day of March, 2019, before me personally came Vipul Dhadda and Joan Park, who are personally known
to me to be the Authorized Signatories of Credit Suisse AG, Cayman Islands Branch; who, being duly sworn, did depose and say that she/he is the Authorized Signatory in such institution, the institution described in and which executed the foregoing
instrument; that she/he executed and delivered said instrument pursuant to authority given by the Board of Directors of such institution; and that she/he acknowledged said instrument to be the free act and deed of said institution. 

 

					
	 /s/ Marjorie E. Bull
	  		  	 Marjorie E. Bull

Notary Public, State of New York

No. 01BU6055282
 Qualified
in New York County
 Commission Expires February 20.2023

	Marjorie E. Bull	  		  	
	Notary Public	  		  	

 

 
 (PLACE STAMP AND SEAL ABOVE) 

[Acknowledgement of IP Assignment] 

 SCHEDULE A 

[Attached] 

 TRADEMARKS 
  

					
	OWNER	  	REG. NO.	  	TRADEMARK
			
	Addison Whitney LLC (f/k/a AW Acquisition LLC)	  	Registration No. 2,328,427	  	ADDISON WHITNEY®
			
	Adheris, LLC (successor by merger to Adheris, Inc.)	  	Registration No. 2,449,977	  	ADHERIS
			
	Adheris, LLC (successor by merger to Adheris, Inc.)	  	Registration No. 4,472,725	  	ADHERENCEFORECASTER
			
	Adheris, LLC (successor by merger to Adheris, Inc.)	  	Registration No. 4,162,146	  	DIRECTADHERE
			
	Adheris, LLC (successor by merger to Adheris, Inc.)	  	Registration No. 4,399,840	  	DIRECTADHEREMM
			
	Adheris, LLC (successor by merger to Adheris, Inc.)	  	Registration No. 4,228,002	  	DIRECTNOTIFY
			
	Adheris, LLC (successor by merger to Adheris, Inc.)	  	Registration No. 4,283,508	  	DIRECTRECOVER
			
	Adheris, LLC (successor by merger to Adheris, Inc.)	  	Registration No. 4,400,108	  	PHARMACISTENGAGE
			
	Adheris, LLC (successor by merger to Adheris, Inc.)	  	Registration No. 4,732,816	  	ADHERISHEALTH
			
	Adheris, LLC (successor by merger to Adheris, Inc.)	  	Registration No. 4,732,746	  	ADHERIS HEALTH
			
	BioSector 2 LLC	  	Registration No. 2,771,189	  	BIOSECTOR 2
			
	Blue Diesel, LLC	  	Registration No. 2,749,759	  	BLUE DIESEL
			
	inVentiv Health Consulting, Inc. (successor by merger to Campbell Alliance Group, Inc.)	  	Registration No. 3,640,918	  	CAMPBELL ALLIANCE
			
	inVentiv Health Consulting, Inc. (successor by merger to Campbell Alliance Group, Inc.)	  	Registration No. 2,550,001	  	CAMPBELLALLIANCE
			
	inVentiv Health Consulting, Inc. (successor by merger to Campbell Alliance Group, Inc.)	  	Registration No. 2,550,000	  	CAMPBELLALLIANCE
			
	inVentiv Health Consulting, Inc. (successor by merger to Campbell Alliance Group, Inc.)	  	Registration No. 3,644,786	  	INNOVATION2VALUE

					
	inVentiv Health Consulting, Inc. (successor by merger to Campbell Alliance Group, Inc.)	  	Registration No. 4,293,051	  	LAUNCH BLUEPRINT
			
	inVentiv Health Consulting, Inc. (successor by merger to Campbell Alliance Group, Inc.)	  	Registration No. 4,293,049	  	LAUNCH JUMP START
			
	inVentiv Health Consulting, Inc. (successor by merger to Campbell Alliance Group, Inc.)	  	Registration No. 3,498,271	  	LAUNCH PLAYBOOK

  

					
	OWNER	  	REG. NO.	  	TRADEMARK
			
	inVentiv Health Consulting, Inc. (successor by merger to Campbell Alliance Group, Inc.)	  	Registration No. 4,293,052	  	LAUNCH ROADMAP
			
	inVentiv Health Consulting, Inc. (successor by merger to Campbell Alliance Group, Inc.)	  	Registration No. 4,362,342	  	MARKETMIND
			
	inVentiv Health Consulting, Inc. (successor by merger to Campbell Alliance Group, Inc.)	  	Registration No. 3,644,785	  	WINNING LABEL
			
	Chandler Chicco Agency, L.L.C.	  	Registration No. 3,664,858	  	ALLIDURA
			
	inVentiv Health Public Relations, LLC (f/k/a Chandler Chicco Companies LLC)	  	Registration No. 4,150,805	  	HEALTHNICITY
			
	inVentiv Health Public Relations, LLC (f/k/a Chandler Chicco Companies LLC)	  	Registration No. 4,109,324	  	INGENDA COMMUNICATIONS
			
	Chandler Chicco Agency, L.L.C.	  	Registration No. 2,353,650	  	THE FREEDOM TO SEE. THE POWER TO DO.
			
	Inventiv Health Public Relations, LLC (f/k/a Chandler Chicco Companies LLC)	  	Registration No. 4,016,511	  	VERSTONE DIGITAL
			
	Gerbig, Snell/Weisheimer Advertising, LLC	  	Registration No. 2,997,802	  	GSW WORLDWIDE

					
	Gerbig, Snell/Weisheimer Advertising, LLC	  	Registration No. 2,995,150	  	GSW
			
	Gerbig, Snell/Weisheimer Advertising, LLC	  	Registration No. 3,768,371	  	INSERV
			
	Gerbig, Snell/Weisheimer Advertising, LLC	  	Registration No. 3,971,562	  	YOUR BRAND DELIVERED.
			
	inVentiv Health Communications, Inc. (f/k/a inVentiv Communications, Inc.)	  	Registration No. 4,045,777	  	AXCELO
			
	inVentiv Health Communications, Inc. (f/k/a inVentiv Communications, Inc.)	  	Registration No. 2,977,610	  	CADENT MEDICAL COMMUNICATIONS
			
	inVentiv Health Communications, Inc. (f/k/a inVentiv Communications, Inc.)	  	Registration No. 2,868,928	  	GERBIG, SNELL/WEISHEIMER
			
	inVentiv Health Communications, Inc. (f/k/a inVentiv Communications, Inc.)	  	Registration No. 4,031,981	  	INTERPHĀZ (STYLIZED)
			
	inVentiv Health Communications, Inc. (f/k/a inVentiv Communications, Inc.)	  	Registration No. 3,419,618	  	PALIO

  

					
	OWNER	  	REG. NO.	  	TRADEMARK
	inVentiv Health Communications, Inc. (f/k/a inVentiv Communications, Inc.)	  	Registration No. 3,437,381	  	STONEFLY (AND DESIGN)
			
	inVentiv Health, Inc.	  	Registration No. 4,239,008	  	ACCOUNTABLE CARE SOLUTIONS POWERED BY INVENTIV MEDICAL MANAGEMENT
			
	inVentiv Health, Inc.	  	Registration No. 4,261,204	  	DONE AS ONE
			
	inVentiv Health, Inc.	  	Registration No. 4,097,977	  	EMBARX
			
	inVentiv Health Research & Insights, LLC (successor by merger to Encuity Research, LLC)	  	Registration No. 4,273,499	  	ENCUITY RESEARCH (& DESIGN)
			
	inVentiv Health, Inc.	  	Registration No. 2,122,524	  	HEALTH PRODUCTS RESEARCH
			
	inVentiv Health, Inc.	  	Registration No. 2,141,811	  	HPR
			
	inVentiv Health, Inc.	  	Registration No. 4,004,261	  	INVENTIV CLINICAL (WORD ONLY)
			
	inVentiv Health, Inc.	  	Registration No. 4,004,262	  	INVENTIV CLINICAL (WORD AND DESIGN)
			
	inVentiv Health, Inc.	  	Registration No. 3,426,747	  	INVENTIV COMMUNICATIONS
			
	inVentiv Health, Inc.	  	Registration No. 3,331,958	  	INVENTIV HEALTH
			
	inVentiv Health, Inc.	  	Registration No. 3,331,961	  	INVENTIV HEALTH (AND DESIGN)
			
	inVentiv Health, Inc.	  	Registration No. 3,786,707	  	INVENTIV HEALTH (DESIGN & COLOR)
			
	inVentiv Health, Inc.	  	Registration No. 3,786,706	  	INVENTIV HEALTH (WORD ONLY)
			
	inVentiv Health, Inc.	  	Registration No. 4,332,517	  	INVENTIV MEDICAL MANAGEMENT
			
	inVentiv Health, Inc.	  	Registration No. 4,352,410	  	INVENTIV PATIENT ACCESS SOLUTIONS

					
	inVentiv Health, Inc.	  	Registration No. 4,299,047	  	INVENTIV RECRUITMENT SERVICES
			
	inVentiv Health, Inc.	  	Registration No. 4,319,608	  	INVENTIV THERAPEUTICS INSTITUTE
			
	inVentiv Health, Inc.	  	Registration No. 4,278,346	  	MOBILE LOCKER
			
	inVentiv Health, Inc.	  	Registration No. 4,147,288	  	MYSTRO
			
	inVentiv Health, Inc.	  	Registration No. 4,332,441	  	REAGENT
			
	inVentiv Health, Inc.	  	Registration No. 4,240,692	  	REPTIVATE
			
	inVentiv Health, Inc.	  	Registration No. 3,967,458	  	SELLING2SCALE
			
	inVentiv Health, Inc.	  	Registration No. 4,112,936	  	SHAREDVOICE
			
	inVentiv Health, Inc.	  	Registration No. 3,251,246	  	THE RX ADVANTAGE (AND DESIGN)

					
	OWNER	  	REG. NO.	  	TRADEMARK
	inVentiv Health, Inc.	  	Registration No. 4,173,017	  	TRANSFORMING PROMISING IDEAS INTO COMMERCIAL RESULTS
			
	inVentiv Health, Inc.	  	Registration No. 4,158,896	  	WE’RE WAITING FOR YOU AT THE GLOBAL CROSSROADS. WE KNOW THE WAY IN HEALTHCARE.
			
	inVentiv Health, Inc.	  	Registration No. 4,678,437	  	PALIO+IGNITE
			
	inVentiv Health, Inc.	  	Registration No. 4,631,133	  	INVENTIV HEALTH CLINICAL
			
	inVentiv Health, Inc.	  	Registration No. 4,683,555	  	 INVENTIV HEALTH

CLINICAL (and Design)

			
	inVentiv Health, Inc.	  	Registration No. 4,188,125	  	ENGAGING INSIGHTS, HEALTHIER OUTCOMES
			
	inVentiv Health, Inc.	  	Registration No. 4,100,261	  	HEALTH & WELLNESS CONSUMER JOURNEY
			
	inVentiv Health, Inc.	  	Registration No. 4,078,238	  	HEALTH CONSUMER JOURNEY
			
	inVentiv Health, Inc.	  	Registration No. 2,232,893	  	HEALTH RESOURCE
			
	inVentiv Health, Inc.	  	Registration No. 4,299,221	  	MEMBERLINK
			
	inVentiv Health, Inc.	  	Registration No. 2,664,875	  	NUTRIENT NEWS
			
	inVentiv Health, Inc.	  	Registration No. 3,639,480	  	NUTRIENT NEWS
			
	inVentiv Health, Inc.	  	Registration No. 4,079,503	  	PATIENT JOURNEY
			
	inVentiv Health, Inc.	  	Registration No. 3,924,183	  	PATIENT LINK
			
	inVentiv Health, Inc.	  	Registration No. 3,944,365	  	PATIENTLINKMC
			
	inVentiv Health, Inc.	  	Registration No. 2,624,986	  	PHARMAWARE
			
	inVentiv Health, Inc.	  	Registration No. 4,208,118	  	PRESCRIBER CENTRIC TARGETING
			
	inVentiv Health, Inc.	  	Registration No. 4,299,175	  	PRESCRIBERLINK
			
	inVentiv Health, Inc.	  	Registration No. 3,944,366	  	ADHERENCE REWARDS

					
			
	inVentiv Health Clinical, Inc. (f/k/a Pharmanet Development Group, Inc.)	  	Registration No. 4,192,799	  	APPLIED KNOWLEDGE. INTELLIGENT SOLUTIONS. (& DESIGN)
			
	inVentiv Health Clinical, Inc. (f/k/a Pharmanet Development Group, Inc.)	  	Registration No. 2,535,459	  	PHARMANET
			
	inVentiv Health Clinical, Inc. (f/k/a Pharmanet Development Group, Inc.)	  	Registration No. 4,056,476	  	SUPERIOR SERVICE. TRUSTED PARTNER
			
	inVentiv Health Clinical, Inc. (successor by merger to inVentiv Health Clinical SRS, LLC)	  	Registration No. 4,087,919	  	WORKING AT THE SPEED OF LIFE
			
	inVentiv Health Clinical, Inc. (successor by merger to Raven Holdco LLC)	  	Registration No. 3,996,345	  	I3

  

					
	OWNER	  	REG. NO.	  	TRADEMARK
	Taylor Strategy Partners, LLC	  	Registration No. 4,305,621	  	TAYLOR STRATEGY PARTNERS
			
	Taylor Strategy Partners, LLC	  	Registration No. 4,305,632	  	TSP TAYLOR STRATEGY PARTNERS

					
	OWNER	  	REG. NO.	  	TRADEMARK
			
	inVentiv Health Clinical, Inc. (successor by merger to Raven Holdco LLC)	  	Registration No. 3,914,368	  	I3
			
	inVentiv Health Clinical, Inc. (successor by merger to Synergos LLC)	  	Registration No. 3,011,364	  	SYNERGO BE WELL. WORK BETTER
			
	 inVentiv Health Research & Insights, LLC

(successor by merger to Encuity Research, LLC)
	  	Registration No. 4,347,921	  	ENCUITY RESEARCH
			
	 inVentiv Health Research & Insights, LLC

(successor by merger to Encuity Research, LLC)
	  	Registration No. 4,347,920	  	ENCUITY RESEARCH
			
	 inVentiv Health Research & Insights, LLC

(successor by merger to Encuity Research, LLC)
	  	Registration No. 4,347,919	  	ENCUITY
			
	 inVentiv Health Research & Insights, LLC

(successor by merger to Encuity Research, LLC)
	  	Registration No. 4,382,636	  	ENCUITY ANSWER SUITE
			
	 Adheris, LLC
 (successor by merger to inVentiv
Medical Management LLC)
	  	Registration No. 4,163,295	  	ADVANCED WARNING AND CONTAINMENT
			
	 Adheris, LLC
 (successor by merger to inVentiv
Medical Management LLC)
	  	Registration No. 2,387,126	  	FISCAL THERAPY
			
	 Adheris, LLC
 (successor by merger to inVentiv
Medical Management LLC)
	  	Registration No. 2,387,125	  	AWAC
			
	 Palio + Ignite, LLC
 (f/k/a Palio
Communications, LLC)
	  	Registration No. 2,641,121	  	NEVER BE FORGOTTEN

					
	The Selva Group, LLC	  	Registration No. 3,176,842	  	THE SELVA GROUP
			
	inVentiv Health, Inc.	  	Registration No. 4,858,509	  	PALIO IGNITED INVENTIV HEALTH
			
	inVentiv Health, Inc.	  	Registration No. 5,147,092	  	PATIENT INHOME
			
	inVentiv Health, Inc.	  	Registration No. 5.147.089	  	PATIENT INOFFICE
			
	inVentiv Health, Inc.	  	Registration No. 5,147.091	  	PATIENT INPHARMACY
			
	inVentiv Health, Inc.	  	Registration No. 5,147,088	  	PHARMACIST INSTORE
			
	inVentiv Health, Inc.	  	Registration No. 5,147,090	  	PRESCRIBER INOFFICE

  

					
	OWNER	  	REG. NO.	  	TRADEMARK
	INC Research, LLC	  	Registration No. 2,039564	  	ADVANCED BIOLOGICS
			
	INC Research, LLC	  	Registration No. 4,649,107	  	

			
	INC Research, LLC	  	Registration No. 2,922,548	  	

			
	INC Research, LLC	  	Registration No. 4,306,597	  	

			
	INC Research, LLC	  	Registration No. 3,961,733	  	INC RESEARCH
			
	INC Research, LLC	  	Registration No. 3,435,125	  	PLANACTIVATION
			
	INC Research, LLC	  	Registration No. 3,435,126	  	PROGRAMACCELERATE
			
	INC Research, LLC	  	Registration No. 3,435,129	  	QUALITYFINISH
			
	INC Research, LLC	  	Registration No. 3,435,127	  	QUICKSTART
			
	INC Research, LLC	  	Registration No. 3,435,124	  	THE TRUSTED PROCESS

 TRADEMARK APPLICATIONS 
  

					
	OWNER	  	SERIAL NO. /	  	TRADEMARK
	inVentiv Health, Inc.	  	Application No. 86/439,541	  	MEMBER INHOME
			
	inVentiv Health, Inc.	  	Application No. 86/439,500	  	MEMBER INOFFICE
			
	inVentiv Health, Inc.	  	Application No. 86/439,520	  	MEMBER INPHARMACY
			
	inVentiv Health, Inc.	  	Application No. 86/439,545	  	PATIENT INMOTION
			
	inVentiv Health, Inc.	  	Application No. 86/439,567	  	PHARMACIST INMOTION
			
	inVentiv Health, Inc.	  	Application No. 86/439,562	  	PRESCRIBER INMOTION
			
	inVentiv Health, Inc.	  	Application No. 86/425,410	  	TRIAL360
			
	inVentiv Health, Inc.	  	Application No. 87/066,197	  	DYNAMIC ADHERENCE
			
	inVentiv Health, Inc.	  	Application No. 86/314,670	  	INTERLOGIX
			
	inVentiv Health, Inc.	  	Application No. 87/440,090	  	CHAMBERLAIN HEALTHCARE PUBLIC RELATIONS
			
	inVentiv Health, Inc.	  	Application No. 87/440,095	  	CHAMBERLAIN HEALTHCARE PUBLIC RELATIONS INVENTIV HEALTH (& DESIGN)

  

					
	OWNER	  	SERIAL NO. /	  	TRADEMARK
	inVentiv Health, Inc.	  	Application No. 87/440,103	  	CHANDLER CHICCO AGENCY
			
	inVentiv Health, Inc.	  	Application No. 87/440,107	  	CHANDLER CHICCO AGENCY INVENTIV HEALTH (& DESIGN)
			
	inVentiv Health, Inc.	  	Application No. 87/440,070	  	INVENTIV HEALTH INCITE
			
	inVentiv Health, Inc.	  	Application No. 87/406,693	  	NAVICOR
			
	inVentiv Health, Inc.	  	Application No. 87/406,778	  	NAVICOR INVENTIV HEALTH (& DESIGN) STACKED
			
	inVentiv Health, Inc.	  	Application No. 87/406,808	  	NAVICOR THE ONCOLOGY AGENCY
			
	inVentiv Health, Inc.	  	Application No. 87/406,742	  	NAVICOR THE ONCOLOGY AGENCY INVENTIV HEALTH (& DESIGN)—ADJACENT
			
	inVentiv Health, Inc.	  	Application No. 87/394,701	  	SHORTENING THE DISTANCE FROM LAB TO LIFE
			
	inVentiv Health, Inc.	  	Application No. 87/406,720	  	THE ONCOLOGY AGENCY
			
	INC Research, LLC	  	Application No. 86/710,826	  	COHORT SHARE
			
	INC Research, LLC	  	Application No. 87/124,101	  	CULTURE OF OPPORTUNITY

 PATENTS 
  

							
	Title	  	Serial No.	  	Patent No.	  	Owner
	Pharmacy Network Computer System And Printer	  	13/471,220	  	8,762,176	  	inVentiv Health, Inc.
				
	Method And Apparatus For Automatically Generating Advisory Information For Pharmacy Patients	  	08/764,139	  	6,240,394	  	inVentiv Health, Inc.
				
	Method And System For Automatically Generating Advisory Information For Pharmacy Patients Along With Normally Transmitted Data	  	09/226,209	  	6,067,524	  	inVentiv Health, Inc.
				
	Method And System For Printing A Combination Pharmaceutical Label And Directed Newsletter	  	09/511,485	  	6,304,849	  	inVentiv Health, Inc.
				
	System To Provide Specific Messages To Patients	  	11/235,083	  	7,309,001	  	inVentiv Health, Inc.
				
	System Of Performing A Retrospective Drug Profile Review Of De-Identified Patients	  	11/573,987	  	7,778,930	  	inVentiv Health, Inc.
				
	System Of Performing A Retrospective Drug Profile Review Of De-Identified Patients	  	12/062,182	  	7,913,900	  	inVentiv Health, Inc.
				
	System And Method For Special Accounts	  	11/538,181	  	7,987,125	  	inVentiv Health, Inc.
				
	Pharmacy Network Computer System And Printer	  	11/366,397	  	8,180,653	  	inVentiv Health, Inc.
				
	Pharmacy Printer System And Method	  	11/748,239	  	8,072,635	  	inVentiv Health, Inc.
				
	Pharmacy Printer System And Method	  	13/229,651	  	8,531,714	  	inVentiv Health, Inc.
				
	Pharmacy Printer System And Method	  	14/709,016	  	9,405,493	  	inVentiv Health, Inc.
				
	Pharmacy Printer System and Method	  	13/967,286	  	9,524,375	  	inVentiv Health, Inc.

 PATENT APPLICATIONS 
  

					
	Title	  	Serial No.	  	Owner
	Pharmacy Printer System and Method	  	15/196,914	  	inVentiv Health, Inc.
			
	Event Based System and Method for Managing Clinical Trial Data	  	15/170,601	  	INC Research, LLC

 COPYRIGHTS 
  

					
	OWNER	  	TITLE	  	REGISTRATION NUMBER
	Chamberlain Communications Group LLC (successor by merger to Medconference, LLC)	  	MedConferenceLive	  	TXu1-205-587
			
	Adheris, LLC (successor by merger to Adheris, Inc.)	  	Know your numbers: exercising your way to a healthy heart	  	TX 5-604-532
			
	inVentiv Health, Inc.	  	The Rxadvantage selling skills participant guide	  	TX 6-509-887
			
	Gerbig, Snell/Weisheimer Advertising, LLC	  	Conquering minds	  	VAu738-971
			
	Gerbig Snell/Weisheimer Advertising, LLC	  	The liberating journey	  	VAu738-972
			
	Gerbig, Snell/Weisheimer Advertising, LLC	  	Americana	  	VAu304-688
			
	inVentiv Health Clinical, LLC	  	Basic statistics in clinical research	  	TXu466-565
			
	inVentiv Commercial Services, LLC (successor by merger to inVentiv Advance Insights, Inc.)	  	IOL market survey 1982, half 2	  	TX 1-073-855
			
	inVentiv Commercial Services, LLC (successor by merger to inVentiv Advance Insights, Inc.)	  	IOL market survey 1982, half 1	  	TX 1-073-854
			
	inVentiv Health, Inc.	  	Get Ahead of Nasal Allergy Symptoms Take-One Card.	  	TX 0008-292-748
			
	INC Research, LLC	  	Kendle Aease form: Kendle Adverse event and safety evaluation form	  	TXu735960

 EXHIBIT C 

Schedule 1.01(d) – Administrative Agent’s Office 

If to the Administrative Agent, to the address, facsimile number, electronic mail address or telephone number specified on Schedule 1.01(d); 

If to the Administrative Agent: 
 JPM Account
Manager Client Processing Specialist 
 10 South Dearborn, Floor L2 

Chicago, IL 60603-2300, United States 

Attention: Stephon Chambers 

Telephone: 312-954-4306 

Facsimile: 844-490-5665 

Email: Jpm.agency.servicing.1@jpmorgan.com; Stephon.Chambers@JPMorgan.com 

with a copy to 
 JPM Backup
Account Manager 
 Client Processing Specialist 

10 South Dearborn, Floor L2 

Chicago, IL 60603-2300, United States 

Attention: Ladesiree Williams 

Telephone: 312-732-2007 

Facsimile: 844-490-5665 

Email: Jpm.agency.servicing.1@jpmorgan.com 

 EXHIBIT D 

Schedule 1.01(e) – Existing Letters of Credit 

(i) Existing Bank of America Closing Date Letters of Credit 
  

											
	 Bank
	  	 LC#
	  	 Applicant
	  	Amount	 	  	 Beneficiary

	 Bank of America, N.A.
	  	68128854	  	inVentiv Health, Inc.	  	$	4,200,000.00	 	  	Citibank, N.A.
	 Bank of America, N.A.
	  	68129398	  	inVentiv Health, Inc.	  	$	10,000.00	 	  	Airlines Reporting Corporation
	 Bank of America, N.A.
	  	68129402	  	inVentiv Health, Inc.	  	$	2,194,500.00	 	  	Donlen Corporation
	 Bank of America, N.A.
	  	68129404	  	inVentiv Health, Inc.	  	$	350,000.00	 	  	GPO Newtown LLC
	 Bank of America, N.A.
	  	68129405	  	inVentiv Health, Inc.	  	$	55,387.58	 	  	Grub & Ellis Company
	 Bank of America, N.A.
	  	68129411	  	inVentiv Health, Inc.	  	$	320,000.00	 	  	La Jolla Executive Center, LLC
	 Bank of America, N.A.
	  	68129413	  	inVentiv Health, Inc.	  	$	291,906.67	 	  	Trinity Centre, LLC
	 Bank of America, N.A.
	  	68129401	  	inVentiv Health, Inc.	  	$	1,100,000.00	 	  	American Express Travel Related Services Company, Inc.
	 Bank of America, N.A.
	  	668129513	  	inVentiv Group Holdings, Inc.1 	  	$	5,450,000.00	 	  	Sentry Insurance A Mutual Company

  

	1 	 Co-Applicant with Double Eagle Intermediate II, Inc. 

 (ii) Existing Bank of America Amendment No. 2 Closing Date Letters of Credit 

 

											
	 Bank
	  	 LC#
	  	 Applicant
	  	Amount	 	  	 Beneficiary

	 Bank of America, N.A.
	  	BOA 68129398	  	inVentiv Health, Inc.	  	$	10,000.00	 	  	Airlines Reporting Corporation
	 Bank of America, N.A.
	  	BOA 68129401	  	inVentiv Health, Inc.	  	$	1,100,000.00	 	  	American Express Travel Related Services Company, Inc.
	 Bank of America, N.A.
	  	BOA 68129404	  	inVentiv Health, Inc.	  	$	350,000.00	 	  	GPO Newtown LLC
	 Bank of America, N.A.
	  	BOA 68129405	  	inVentiv Health, Inc.	  	$	55,387.58	 	  	Grub & Ellis Company
	 Bank of America, N.A.
	  	BOA 68129413	  	inVentiv Health, Inc.	  	$	291,906.67	 	  	Trinity Centre, LLC
		
	 (iii) Existing Credit Suisse Amendment No. 2 Closing Date Letters of Credit

 
	  
 
	  	
	 Bank
	  	 LC#
	  	 Applicant
	  	Amount	 	  	 Beneficiary

	 Credit Suisse AG, Cayman Islands Branch, or its affiliates
	  	TS-07010413BLC	  	INC Research LLC	  	AU$	104,173.77	 	  	Barclays Bank PLC
	 Credit Suisse AG, Cayman Islands Branch, or its affiliates
	  	TS-07010414BLC	  	INC Research LLC	  	€	698,172.66	 	  	Barclays Bank PLC
	 Credit Suisse AG, Cayman Islands Branch, or its affiliates
	  	TS-07010557	  	inVentiv Health, Inc.	  	$	4,000,000.00	 	  	SG 2007-FL14 NJOP Holdings, LLC C/O Trimont Real Estate Advisors, LLC
	 Credit Suisse AG, Cayman Islands Branch, or its affiliates
	  	TS-07010760NYB	  	Syneos Health, Inc.	  	$	6,250,000.00	 	  	Sentry Insurance: A Mutual Company
	 Credit Suisse AG, Cayman Islands Branch, or its affiliates
	  	TS-07011181	  	Syneos Health, Inc.	  	$	4,757,390.00	 	  	American Express Company
	 Credit Suisse AG, Cayman Islands Branch, or its affiliates
	  	TS-07011238NYB	  	Syneos Health, Inc.	  	$	1,600,000.00	 	  	 National Union Fire Insurance Co. of Pittsburgh, Pa., and

 

		  		  		  				  	 American Home Assurance Company, and
  

The Insurance Company of the State of Pennsylvania, and
  

Commerce and Industry Insurance Company, and
  

AIG Property Casualty Company, and
  

Illinois National Insurance Co., and
  

Granite State Insurance Company, and
  

AIU Insurance Company; and
  

AIG Assurance Company, and
  

New Hampshire Insurance Company

											
		
	 (iii) Existing ING Amendment No. 2 Closing Date Letters of Credit

 
	  
 
	  	
	 Bank
	  	 LC#
	  	 Applicant
	  	Amount	 	  	 Beneficiary

	 ING Capital LLC
	  	ING I0001007	  	inVentiv Health Clinical, Inc.	  	€	189,823.00	 	  	ING Bank France
	 ING Capital LLC
	  	ING I0000859	  	Syneos Health, Inc.	  	€	46,840.00	 	  	ING Belgium SA NV
	 ING Capital LLC
	  	ING I0001074	  	Syneos Health, Inc.	  	€	242,073.00	 	  	ING Bank France
	 ING Capital LLC
	  	ING I0000827	  	Syneos Health, Inc.	  	€	83,683.95	 	  	ING Bank A Branch of ING DIBA AG

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