Document:

Exhibit 10.27

 

Execution Version

 

 

REGISTRATION RIGHTS AGREEMENT 

 

This REGISTRATION RIGHTS AGREEMENT (this “Agreement”),
dated as of May 3, 2022, is by and between CF Principal Investments LLC, a Delaware limited liability company (the “Investor”),
and Biotech Acquisition Company, a Cayman Islands exempted company (the “Company”).

 

RECITALS 

 

A. The Company and the Investor have entered into that certain Common
Stock Purchase Agreement, dated as of the date hereof (the “Purchase Agreement”), pursuant to which the Company
may issue, from time to time, to the Investor up to the lesser of (i) $75,000,000 in aggregate gross purchase price of newly issued shares
of the Company’s Common Stock, and (ii) the Exchange Cap (to the extent applicable under Section 3.3 of the Purchase Agreement),
as provided for therein.

 

B. Pursuant to the terms of, and in consideration for the Investor
entering into, the Purchase Agreement, the Company shall cause to be issued to the Investor the Commitment Fee in accordance with the
terms of the Purchase Agreement.

 

C. Pursuant to the terms of, and in consideration for the Investor
entering into, the Purchase Agreement, and to induce the Investor to execute and deliver the Purchase Agreement, the Company has agreed
to provide the Investor with certain registration rights with respect to the Registrable Securities (as defined herein) as set forth herein.

 

AGREEMENT 

 

NOW, THEREFORE, in consideration of the representations, warranties,
covenants and agreements contained herein and in the Purchase Agreement, and for other good and valuable consideration, the receipt and
sufficiency of which is hereby acknowledged, intending to be legally bound hereby, the Company and the Investor hereby agree as follows:

1. Definitions.

 

Capitalized terms used herein and not otherwise defined herein shall
have the respective meanings set forth in the Purchase Agreement. As used in this Agreement, the following terms shall have the following
meanings:

 

(a) “Business Day” means any day other than
Saturday, Sunday or any other day on which commercial banks in New York, New York are authorized or required by law to remain closed.

 

(b) “Commission” means the U.S. Securities
and Exchange Commission or any successor entity.

 

(c) “Effective Date” means the date that
the applicable Registration Statement (or any post-effective amendment thereto) has been declared effective by the Commission.

 

(d) “Person” means any person or entity,
whether a natural person, trustee, corporation, partnership, limited partnership, limited liability company, trust, unincorporated organization,
business association, firm, joint venture, governmental agency or authority.

 

(e) “Prospectus” means the prospectus in
the form included in the Registration Statement at the applicable Effective Date of the Registration Statement, as supplemented from time
to time by any Prospectus Supplement, including the documents incorporated by reference therein.

 

(f) “Prospectus Supplement” means any prospectus
supplement to the Prospectus filed with the Commission from time to time pursuant to Rule 424(b) under the Securities Act, including the
documents incorporated by reference therein.

 

     

     

    

 

(g) “register,” “registered,”
and “registration” refer to a registration effected by preparing and filing one or more Registration Statements
in compliance with the Securities Act and pursuant to Rule 415 and the declaration of effectiveness of such Registration Statement(s)
by the Commission.

 

(h) “Registrable Securities” means all of
(i) the Shares, (ii) the Commitment Fee and (iii) any capital stock of the Company issued or issuable with respect to such Shares or Commitment
Fee, including, without limitation, (A) as a result of any stock split, stock dividend, recapitalization, exchange or similar event or
otherwise and (B) shares of capital stock of the Company into which the shares of Common Stock are converted or exchanged and shares of
capital stock of a successor entity into which the shares of Common Stock are converted or exchanged, in each case until such time as
such securities cease to be Registrable Securities pursuant to Section 2(f).

 

(i) “Registration Statement” means a registration
statement or registration statements of the Company filed under the Securities Act covering the resale by the Investor of Registrable
Securities, as such registration statement or registration statements may be amended and supplemented from time to time, including all
documents filed as part thereof or incorporated by reference therein.

 

(j) “Rule 144” means Rule 144 promulgated
by the Commission under the Securities Act, as such rule may be amended from time to time, or any other similar or successor rule or regulation
of the Commission that may at any time permit the Investor to sell securities of the Company to the public without registration.

 

(k) “Rule 415” means Rule 415 promulgated
by the Commission under the Securities Act, as such rule may be amended from time to time, or any other similar or successor rule or regulation
of the Commission providing for offering securities on a delayed or continuous basis.

2. Registration.

 

(a) Mandatory Registration. The Company shall prepare and, as
soon as practicable, but in no case greater than thirty (30) days after the closing of the Merger, submit or file with the Commission
an initial Registration Statement on Form S-1 or Form S-3 (if the Company is then eligible to use a Form S-3 registration statement),
in each case, covering the resale by the Investor of the maximum number of Registrable Securities as shall be permitted to be included
thereon in accordance with applicable Commission rules, regulations and interpretations (determined as of two Business Days prior to such
submission or filing) (the “Initial Registration Statement”). The Company shall use its commercially reasonable
efforts to have the Initial Registration Statement declared effective by the Commission as soon as reasonably practicable following the
filing thereof with the Commission, but no later than the earlier of (i) the 120th calendar day following the filing date thereof
if the Commission notifies the Company that it will “review” the Initial Registration Statement (including a limited review)
and (ii) the fifth (5th) Business Day after the date the Company is notified (orally or in writing, whichever is earlier) by
the Commission that the Initial Registration Statement will not be “reviewed” or will not be subject to further review; provided,
however, that the Company’s obligations to include the Registrable Securities in the Initial Registration Statement are contingent
upon Investor furnishing in writing to the Company such information, and executing such documents, in connection with such registration
as the Company may reasonably request in accordance with Section 4(a); provided, further, that the Company shall be entitled to
postpone and suspend the effectiveness or use of the Registration Statement, if applicable, as permitted hereunder.

 

(b) Legal Counsel. Subject to Section 5 hereof, the Investor
shall have the right to select one legal counsel to review and oversee, solely on its behalf, any registration pursuant to this Section
2 (“Legal Counsel”), which shall be Covington & Burling LLP, or such other counsel as thereafter designated
by the Investor. The Company shall have no obligation to reimburse the Investor for any legal fees and expenses of the Legal Counsel incurred
in connection with the transactions contemplated hereby.

 

(c) Sufficient Number of Shares Registered. If at any time all
Registrable Securities are not covered by the Initial Registration Statement filed pursuant to Section 2(a), as a result of Section 2(e)
or otherwise, the Company shall use its commercially reasonable efforts to file with the Commission one or more additional Registration
Statements so as to cover all of the Registrable Securities not covered by such Initial Registration Statement, in each case, as soon
as practicable (taking into account any position of the staff of the Commission (“Staff”) with respect to the
date on which the Staff will permit such additional Registration Statement(s) to be filed with the Commission and the rules and regulations
of the Commission) (each such additional Registration Statement, a “New Registration Statement”). The Company
shall use its commercially reasonable efforts to cause each such New Registration Statement to become effective as soon as reasonably
practicable following the filing thereof with the Commission.

 

    2

     

    

 

(d) No Inclusion of Other Securities; Statutory Underwriter Status.
In no event shall the Company include any securities other than Registrable Securities on any Registration Statement pursuant to Section
2(a) or Section 2(c) without consulting the Investor and Legal Counsel prior to filing such Registration Statement with the Commission.
The Investor acknowledges that it will be disclosed as an “underwriter” and a “selling stockholder” in each Registration
Statement and in any Prospectus contained therein to the extent required by applicable law and to the extent the Prospectus is related
to the resale of Registrable Securities.

 

(e) Offering. If the Staff or the Commission seeks to prevent
the Company from including any or all of the Registrable Securities proposed to be registered under a Registration Statement due to limitations
on the use of Rule 415, or if after the filing of any Registration Statement pursuant to Section 2(a) or Section 2(c), the Company is
otherwise required by the Staff or the Commission to reduce the number of Registrable Securities included in such Registration Statement,
then the Company shall reduce the number of Registrable Securities to be included in such Registration Statement (after consultation with
the Investor and Legal Counsel as to the specific Registrable Securities to be removed therefrom) to the maximum number of securities
as is permitted to be registered by the Commission. In the event of any reduction in Registrable Securities pursuant to this paragraph,
the Company shall use its commercially reasonable efforts to file one or more New Registration Statements with the Commission in accordance
with Section 2(c) until such time as all Registrable Securities have been included in Registration Statements that have been declared
effective and the Prospectuses contained therein are available for use by the Investor. Notwithstanding any provision herein or in the
Purchase Agreement to the contrary, the Company’s obligations to register Registrable Securities (and any related conditions to
the Investor’s obligations) shall be qualified as necessary to comport with any requirement of the Staff or the Commission.

 

(f) Any Registrable Security shall cease to be a “Registrable
Security” at the earliest of the following: (i) when a Registration Statement covering such Registrable Security becomes or has
been declared effective by the Commission and such Registrable Security has been sold or disposed of pursuant to such effective Registration
Statement; (ii) when such Registrable Security is held by the Company or one of its Subsidiaries; (iii) the date that is the first (1st)
anniversary of the date of termination of the Purchase Agreement in accordance with Section 8.1 of the Purchase Agreement; and (iv) when
such Registrable Security may be sold under Rule 144 without regard to volume and manner of sale limitations and Form 144 filing requirements.

 

3. Related Obligations.

 

For the duration of the Registration Period (as defined herein), the
Company shall use its commercially reasonable efforts to effect the registration of the Registrable Securities in accordance with the
intended method of disposition thereof, and, pursuant thereto, during the term of this Agreement, the Company shall have the following
obligations:

 

(a) The Company shall promptly, and in any case no more than thirty
(30) days, after the later to occur of (i) the date of this Agreement and (ii) the closing of the Merger, prepare and file with the Commission
the Initial Registration Statement pursuant to Section 2(a) hereof and one or more New Registration Statements pursuant to Section 2(c)
hereof with respect to the Registrable Securities, as applicable, and the Company shall use its commercially reasonable efforts to cause
each such Registration Statement to become effective as soon as practicable after such filing. Subject to Allowable Grace Periods, the
Company shall use its commercially reasonable efforts to keep each Registration Statement effective (and the Prospectus contained therein
available for use) at all times until the earlier of (i) the date on which the Investor shall have sold all of the Registrable Securities
covered by such Registration Statement and (ii) the date of termination of the Purchase Agreement if as of such termination date the Investor
holds no Registrable Securities (or, if applicable, the date on which such securities cease to be Registrable Securities after the date
of termination of the Purchase Agreement) (the “Registration Period”). Notwithstanding anything to the contrary
contained in this Agreement (but subject to the provisions of Section 3(o) hereof), the Company shall ensure that, when filed and at all
times while effective, each Registration Statement (including, without limitation, all amendments and supplements thereto) and the Prospectus
(including, without limitation, all amendments and supplements thereto) used in connection with such Registration Statement shall not
contain any untrue statement of a material fact or omit to state a material fact required to be stated therein, or necessary to make the
statements therein (in the case of Prospectuses, in the light of the circumstances in which they were made) not misleading.

 

    3

     

    

 

(b) Subject to Section 3(o) of this Agreement, the Company shall use
its commercially reasonable efforts to prepare and file with the Commission such amendments (including, without limitation, post-effective
amendments) and supplements to each Registration Statement and the Prospectus used in connection with each such Registration Statement,
which Prospectus is to be filed pursuant to Rule 424 promulgated under the Securities Act, as may be necessary to keep each such Registration
Statement effective (and the Prospectus contained therein current and available for use) at all times during the Registration Period for
such Registration Statement, and, during such period, comply with the provisions of the Securities Act with respect to the disposition
of all Registrable Securities of the Company required to be covered by such Registration Statement until such time as all of such Registrable
Securities shall have been disposed of in accordance with the intended methods of disposition by the Investor as set forth in such Registration
Statement. Without limiting the generality of the foregoing, the Company covenants and agrees that (i) on the second (2nd) Business Day
immediately following the Effective Date of the Initial Registration Statement and any New Registration Statement (or any post-effective
amendment thereto), the Company shall file with the Commission in accordance with Rule 424(b) under the Securities Act the final Prospectus
to be used in connection with sales pursuant to such Registration Statement (or post-effective amendment thereto), and (ii) if the transactions
contemplated by any VWAP Purchase are material to the Company (individually or collectively with all other prior VWAP Purchases, the consummation
of which have not previously been reported in any Prospectus Supplement filed with the Commission under Rule 424(b) under the Securities
Act or in any report, statement or other document filed by the Company with the Commission under the Exchange Act), or if otherwise required
under the Securities Act (or the interpretations of the Commission thereof), in each case as reasonably determined by the Company, then,
on the first (1st) Business Day immediately following the VWAP Purchase Date, if a VWAP Purchase Notice was properly delivered to the
Investor hereunder in connection with such VWAP Purchase, the Company shall file with the Commission a Prospectus Supplement pursuant
to Rule 424(b) under the Securities Act with respect to the VWAP Purchase(s), the total VWAP Purchase Price for the Shares subject to
such VWAP Purchase(s) (as applicable), the applicable VWAP Purchase Price(s) for such Shares and the net proceeds that are to be (and,
if applicable, have been) received by the Company from the sale of such Shares. To the extent not previously disclosed in the Prospectus
or a Prospectus Supplement, the Company shall disclose in its Quarterly Reports on Form 10-Q and in its Annual Reports on Form 10-K the
information described in the immediately preceding sentence relating to all VWAP Purchase(s) consummated during the relevant fiscal quarter
and shall file such Quarterly Reports and Annual Reports with the Commission within the applicable time period prescribed for such report
under the Exchange Act. In the case of amendments and supplements to any Registration Statement or Prospectus related thereto that are
required to be filed pursuant to this Agreement (including, without limitation, pursuant to this Section 3(b)) by reason of the Company
filing a report on Form 8-K, Form 10-Q or Form 10-K or any analogous report under the Exchange Act, the Company shall have incorporated
such report by reference into such Registration Statement and Prospectus, if applicable, or shall file such amendments or supplements
to the Registration Statement or Prospectus with the Commission on the same day on which the Exchange Act report is filed that created
the requirement for the Company to amend or supplement such Registration Statement or Prospectus, for the purpose of including or incorporating
such report into such Registration Statement and Prospectus. The Company consents to the use of the Prospectus (including, without limitation,
any supplement thereto) included in each Registration Statement in accordance with the provisions of the Securities Act and with the securities
or “Blue Sky” laws of the jurisdictions in which the Registrable Securities may be sold by the Investor, in connection with
the resale of the Registrable Securities and for such period of time thereafter as such Prospectus (including, without limitation, any
supplement thereto) (or in lieu thereof, the notice referred to in Rule 173(a) under the Securities Act) is required by the Securities
Act to be delivered in connection with resales of Registrable Securities.

 

(c) The Company shall (i) permit Legal Counsel an opportunity to review
and comment upon (A) each Registration Statement at least three (3) Business Days prior to its filing with the Commission and (B) all
amendments and supplements to each Registration Statement (including, without limitation, the Prospectus contained therein) (except for
Annual Reports on Form 10-K, Quarterly Reports on Form 10-Q, Current Reports on Form 8-K, and any similar or successor reports or Prospectus
Supplements the contents of which is limited to that set forth in such reports) within a reasonable number of days prior to their filing
with the Commission, and (ii) shall reasonably consider any reasonable and timely comments of the Investor and Legal Counsel on any such
Registration Statement or amendment or supplement thereto or to any Prospectus contained therein. The Company shall promptly furnish to
Legal Counsel, without charge, electronic copies of any correspondence from the Commission or the Staff to the Company or its representatives
relating to each Registration Statement (which correspondence shall be redacted to exclude any material, non-public information regarding
the Company or any of its Subsidiaries).

 

    4

     

    

 

(d) Without limiting any obligation of the Company under the Purchase
Agreement, the Company shall promptly furnish to the Investor, without charge, (i) after the same is prepared and filed with the Commission,
at least one (1) electronic copy of each Registration Statement and any amendment(s) and supplement(s) thereto, including, without limitation,
all documents incorporated therein by reference, if requested by the Investor, (ii) upon the effectiveness of each Registration Statement,
one (1) electronic copy of the Prospectus included in such Registration Statement and all amendments and supplements thereto and (iii)
copies of any final Prospectus and any Prospectus Supplement thereto, as the Investor may reasonably request from time to time in order
to facilitate the disposition of the Registrable Securities owned by the Investor; provided, however, the Company shall not be
required to furnish any document (other than the Prospectus, which may be provided in .PDF format) to the Investor to the extent such
document is available on EDGAR.

 

(e) The Company shall take such action as is reasonably necessary to
(i) register and qualify, unless an exemption from registration and qualification applies, the resale by the Investor of the Registrable
Securities covered by a Registration Statement under such other securities or “Blue Sky” laws of all applicable jurisdictions
in the United States, (ii) prepare and file in those jurisdictions, such amendments (including, without limitation, post-effective amendments)
and supplements to such registrations and qualifications as may be necessary to maintain the effectiveness thereof during the Registration
Period, (iii) take such other actions as may be reasonably necessary to maintain such registrations and qualifications in effect at all
times during the Registration Period, and (iv) take all other actions reasonably necessary or advisable to qualify the Registrable Securities
for sale in such jurisdictions; provided, however, the Company shall not be required in connection therewith or as a condition
thereto to (A) qualify to do business in any jurisdiction where it would not otherwise be required to qualify but for this Section 3(e),
(B) subject itself to general taxation in any such jurisdiction, or (C) file a general consent to service of process in any such jurisdiction.
The Company shall promptly notify Legal Counsel and the Investor of the receipt by the Company of any notification with respect to the
suspension of the registration or qualification of any of the Registrable Securities for sale under the securities or “Blue Sky”
laws of any jurisdiction in the United States or its receipt of actual notice of the initiation or threatening of any proceeding for such
purpose.

 

(f) The Company shall notify Legal Counsel and the Investor in writing
of the happening of any event, as promptly as reasonably practicable after becoming aware of such event, as a result of which the Prospectus
included in a Registration Statement, as then in effect, includes an untrue statement of a material fact or omits to state a material
fact required to be stated therein or necessary to make the statements therein, in the light of the circumstances under which they were
made, not misleading (provided that in no event shall such notice contain any material, non-public information regarding the Company or
any of its Subsidiaries), and, subject to Section 3(o), promptly prepare a supplement or amendment to such Registration Statement and
such Prospectus contained therein to correct such untrue statement or omission. The Company shall respond as promptly as reasonably practicable
to any comments received from the Commission with respect to a Registration Statement or any amendment thereto.

 

(g) The Company shall (i) use its reasonable best efforts to prevent
the issuance of any stop order or other suspension of effectiveness of a Registration Statement or the use of any Prospectus contained
therein, or the suspension of the qualification, or the loss of an exemption from qualification, of any of the Registrable Securities
for sale in any jurisdiction and, if such an order or suspension is issued, to obtain the withdrawal of such order or suspension at the
earliest possible time and (ii) notify Legal Counsel and the Investor of the issuance of such order and the resolution thereof or its
receipt of actual notice of the initiation or threat of any proceeding.

 

(h) The Company shall hold in confidence and not make any disclosure
of information concerning the Investor provided to the Company, unless (i) disclosure of such information is necessary to comply with
federal or state securities laws, (ii) the disclosure of such information is necessary to avoid or correct a misstatement or omission
in any Registration Statement or is otherwise required to be disclosed in such Registration Statement pursuant to the Securities Act,
(iii) the release of such information is ordered pursuant to a subpoena or other final, non-appealable order from a court or governmental
body of competent jurisdiction, or (iv) such information has been made generally available to the public other than by disclosure in violation
of this Agreement or any other Transaction Document. The Company agrees that it shall, upon learning that disclosure of such information
concerning the Investor is sought in or by a court or governmental body of competent jurisdiction or through other means, give prompt
written notice to the Investor and allow the Investor, at the Investor’s expense, to undertake appropriate action to prevent disclosure
of, or to obtain a protective order for, such information.

 

    5

     

    

 

(i) Without limiting any obligation of the Company under the Purchase
Agreement, the Company shall use its reasonable best efforts either to (i) cause all of the Registrable Securities covered by each Registration
Statement to be listed on the Principal Market, or (ii) secure designation and quotation of all of the Registrable Securities covered
by each Registration Statement on an Alternative Market. The Company shall pay all fees and expenses in connection with satisfying its
obligation under this Section 3(i).

 

(j) The Company shall cooperate with the Investor and, to the extent
applicable, use its commercially reasonable efforts to facilitate the timely preparation and delivery of Registrable Securities, as DWAC
Shares, to be offered pursuant to a Registration Statement and enable such DWAC Shares to be in such denominations or amounts (as the
case may be) as the Investor may reasonably request from time to time. Investor hereby agrees that it shall cooperate with the Company,
its counsel and Transfer Agent in connection with any issuances of DWAC Shares, and hereby represents, warrants and covenants to the Company
that that it will resell such DWAC Shares only pursuant to the Registration Statement in which such DWAC Shares are included, in a manner
described under the caption “Plan of Distribution” in such Registration Statement, and in a manner in compliance with all
applicable U.S. federal and state securities laws, rules and regulations, including, without limitation, any applicable prospectus delivery
requirements of the Securities Act. At the time such DWAC Shares are offered and sold pursuant to the Registration Statement, such DWAC
Shares shall be free from all restrictive legends (except as otherwise required by this Agreement, the Purchase Agreement or applicable
federal or state securities laws) and may be transmitted by the transfer agent to the Investor by crediting an account at DTC as directed
in writing by the Investor.

 

(k) Upon the written request of the Investor, the Company shall use
its commercially reasonable efforts to, as soon as reasonably practicable after receipt of notice from the Investor and subject to Section
3(o) hereof, (i) incorporate in a Prospectus Supplement or post-effective amendment such information as the Investor reasonably requests
to be included therein relating to the sale and distribution of Registrable Securities, including, without limitation, information with
respect to the number of Registrable Securities being offered or sold, the purchase price being paid therefor and any other terms of the
offering of the Registrable Securities to be sold in such offering; (ii) make all required filings of such Prospectus Supplement or post-effective
amendment after being notified of the matters to be incorporated in such Prospectus Supplement or post-effective amendment; and (iii)
supplement or make amendments to any Registration Statement or Prospectus contained therein if reasonably requested by the Investor.

 

(l) The Company shall use its commercially reasonable efforts to cause
the Registrable Securities covered by a Registration Statement to be registered with or approved by such other governmental agencies or
authorities in the United States as may be necessary to consummate the disposition of such Registrable Securities.

 

(m) The Company shall make generally available to its security holders
(which may be satisfied by making such information available on EDGAR) as soon as practicable, but not later than ninety (90) days after
the close of the period covered thereby, an earnings statement (in form complying with, and in the manner provided by, the provisions
of Rule 158 under the Securities Act) covering a twelve-month period beginning not later than the first day of the Company’s fiscal
quarter next following the applicable Effective Date of each Registration Statement.

 

(n) The Company shall otherwise use its commercially reasonable efforts
to comply with all applicable rules and regulations of the Commission in connection with any registration hereunder.

 

    6

     

    

 

(o) Notwithstanding anything to the contrary contained herein (but
subject to the last sentence of this Section 3(o)), at any time, the Company may, upon written notice to Investor, delay the filing or
effectiveness of any Registration Statement, or suspend Investor’s use of any prospectus that is a part of any Registration Statement
(in which event the Investor shall discontinue sales of the Registrable Securities pursuant to such Registration Statement contemplated
by this Agreement, but shall settle any previously made sales of Registrable Securities) if the Company determines that in order for such
Registration Statement or prospectus not to contain a material misstatement or omission, (i) an amendment or supplement thereto would
be needed to include information that would at that time, (ii) the negotiation or consummation of a transaction by the Company or its
subsidiaries is pending or an event has occurred, which negotiation, consummation or event the Company’s board of directors reasonably
believes would require additional disclosure by the Company in such Registration Statement or prospectus of material information that
the Company has a bona fide business purpose for keeping confidential and the non-disclosure of which in such Registration Statement or
prospectus would be expected, in the reasonable determination of the Company’s board of directors, to cause such Registration Statement
or prospectus to fail to comply with applicable disclosure requirements, or (iii) in the good faith judgment of the majority of the members
of the Company’s board of directors, such filing, effectiveness or use of such Registration Statement or prospectus, as applicable,
would be seriously detrimental to the Company and the majority of the members of the Company’s board of directors concludes as a
result that it is essential to defer such filing, effectiveness or use (each, an “Allowable Grace Period”);
provided, however, that in no event shall the delay or suspend the filing, effectiveness or use of any Registration Statement or
prospectus for a period that exceeds sixty (60) consecutive calendar days or an aggregate of ninety (90) total calendar days during any
twelve (12) month period; and provided, further, the Company shall not effect any such suspension during the three-Business Day
period following the VWAP Purchase Share Delivery Date for each VWAP Purchase. Upon disclosure of such information or the termination
of the condition described above, the Company shall provide prompt notice, but in any event within two (2) Business Days of such disclosure
or termination, to the Investor and shall promptly terminate any suspension or delay it has put into effect and shall take such other
reasonable actions to permit registered sales of Registrable Securities as contemplated in this Agreement (including as set forth in the
first sentence of Section 3(f) with respect to the information giving rise thereto unless such material, non-public information is no
longer applicable). Notwithstanding anything to the contrary contained in this Section 3(o), the Company shall cause its Transfer Agent
to deliver DWAC Shares to a transferee of the Investor in accordance with the terms of the Purchase Agreement in connection with any sale
of Registrable Securities with respect to which (A) the Company has made a sale to Investor and (B) the Investor has entered into a contract
for sale, and delivered a copy of the Prospectus included as part of the particular Registration Statement to the extent applicable, in
each case prior to the Investor’s receipt of the notice of an Allowable Grace Period and for which the Investor has not yet settled.

 

4. Obligations
of the Investor.

 

(a) At least five (5) Business Days prior to the first anticipated
filing date of each Registration Statement (or such shorter period to which the parties agree), the Company shall notify the Investor
in writing of the information the Company requires from the Investor with respect to such Registration Statement. It shall be a condition
precedent to the obligations of the Company to complete the registration pursuant to this Agreement with respect to the Registrable Securities
of the Investor that the Investor shall (i) promptly furnish to the Company such information regarding itself, the Registrable Securities
held by it and the intended method of disposition of the Registrable Securities held by it, as shall be reasonably required to effect
and maintain the effectiveness of the registration of such Registrable Securities and (ii) promptly execute such documents in connection
with such registration as the Company may reasonably request.

 

(b) The Investor, by its acceptance of the Registrable Securities,
agrees to cooperate with the Company as reasonably requested by the Company in connection with the preparation and filing of each Registration
Statement hereunder, unless the Investor has notified the Company in writing of the Investor’s election to exclude all of the Investor’s
Registrable Securities from such Registration Statement.

 

(c) The Investor agrees that, upon receipt of any notice from the Company
of the happening of any event of the kind described in Section 3(o) or the first sentence of 3(f), the Investor shall as soon as is reasonably
practicable discontinue disposition of Registrable Securities pursuant to any Registration Statement(s) covering such Registrable Securities
until the Investor’s receipt of the copies of the supplemented or amended Prospectus contemplated by Section 3(o) or the first sentence
of Section 3(f) or receipt of notice that no supplement or amendment is required. Notwithstanding anything to the contrary in this Section
4(c), the Company shall cause its Transfer Agent to deliver DWAC Shares to a transferee of the Investor in accordance with the terms of
the Purchase Agreement in connection with any sale of Registrable Securities with respect to which the Investor has entered into a contract
for sale prior to the Investor’s receipt of a notice from the Company of the happening of any event of the kind described in Section
3(o) or the first sentence of Section 3(f) and for which the Investor has not yet settled.

 

(d) The Investor covenants and agrees that it shall comply with the
prospectus delivery and other requirements of the Securities Act as applicable to it in connection with sales of Registrable Securities
pursuant to a Registration Statement.

    7

     

    

5. Expenses of
Registration.

 

All reasonable expenses of the Company, other than sales or brokerage
commissions and fees and disbursements of counsel for, and other expenses of, the Investor, incurred in connection with registrations,
filings or qualifications pursuant to Sections 2 and 3, including, without limitation, all registration, listing and qualifications fees,
printers and accounting fees incurred by the Company, and fees and disbursements of counsel for the Company, shall be paid by the Company.

 

6. Indemnification.

 

(a) In the event any Registrable Securities are included in any Registration
Statement under this Agreement, to the fullest extent permitted by law, the Company will, and hereby does, indemnify, hold harmless and
defend the Investor, each of its directors, officers, shareholders, members, partners, employees, agents, representatives (and any other
Persons with a functionally equivalent role of a Person holding such titles notwithstanding the lack of such title or any other title)
and each Person, if any, who controls the Investor within the meaning of the Securities Act or the Exchange Act and each of the directors,
officers, shareholders, members, partners, employees, agents, representatives (and any other Persons with a functionally equivalent role
of a Person holding such titles notwithstanding the lack of such title or any other title) of such controlling Persons (each, an “Investor
Party” and collectively, the “Investor Parties”), against any losses, obligations, claims, damages,
liabilities, contingencies, judgments, fines, penalties, charges, costs (including, without limitation, court costs, reasonable attorneys’
fees, costs of defense and investigation), amounts paid in settlement or expenses, joint or several, (collectively, “Claims”)
reasonably incurred in investigating, preparing or defending any action, claim, suit, inquiry, proceeding, investigation or appeal taken
from the foregoing by or before any court or governmental, administrative or other regulatory agency, body or the Commission, whether
pending or threatened, whether or not an Investor Party is or may be a party thereto (“Indemnified Damages”),
to which any of them may become subject insofar as such Claims (or actions or proceedings, whether commenced or threatened, in respect
thereof) arise out of or are based upon: (i) any untrue statement or alleged untrue statement of a material fact in a Registration Statement
or any post-effective amendment thereto or in any filing made in connection with the qualification of the offering under the securities
or other “Blue Sky” laws of any jurisdiction in which Registrable Securities are offered, or the omission or alleged omission
to state a material fact required to be stated therein or necessary to make the statements therein not misleading or (ii) any untrue statement
or alleged untrue statement of a material fact contained in any Prospectus (as amended or supplemented) or in any Prospectus Supplement
or the omission or alleged omission to state therein any material fact necessary to make the statements made therein, in light of the
circumstances under which the statements therein were made, not misleading (the matters in the foregoing clauses (i) and (ii) being, collectively,
“Violations”). Subject to Section 6(c), the Company shall reimburse the Investor Parties, promptly as such expenses
are incurred and are due and payable, for any reasonable and documented legal fees or other reasonable and documented expenses incurred
by them in connection with investigating or defending any such Claim. Notwithstanding anything to the contrary contained herein, the indemnification
agreement contained in this Section 6(a): (i) shall not apply to a Claim by an Investor Party arising out of or based upon a Violation
which occurs in reliance upon and in conformity with information furnished in writing to the Company by such Investor Party for such Investor
Party expressly for use in connection with the preparation of such Registration Statement, Prospectus or Prospectus Supplement or any
such amendment thereof or supplement thereto (it being hereby acknowledged and agreed that the written information set forth on Exhibit
A attached hereto is the only written information furnished to the Company by or on behalf of the Investor expressly for use in any
Registration Statement, Prospectus or Prospectus Supplement); (ii) shall not be available to the Investor to the extent such Claim is
based on a failure of the Investor to deliver or to cause to be delivered the Prospectus (as amended or supplemented) made available by
the Company (to the extent applicable), including, without limitation, a corrected Prospectus; and (iii) shall not apply to amounts paid
in settlement of any Claim if such settlement is effected without the prior written consent of the Company, which consent shall not be
unreasonably withheld or delayed. Such indemnity shall remain in full force and effect regardless of any investigation made by or on behalf
of the Investor Party.

 

    8

     

    

 

(b) In connection with any Registration Statement in which the Investor
is participating, the Investor agrees to severally and not jointly indemnify, hold harmless and defend, to the same extent and in the
same manner as is set forth in Section 6(a), the Company, each of its directors, each of its officers who signs the Registration Statement
and each Person, if any, who controls the Company within the meaning of the Securities Act or the Exchange Act (each, an “Company
Party”), against any Claim or Indemnified Damages to which any of them may become subject, under the Securities Act, the
Exchange Act or otherwise, insofar as such Claim or Indemnified Damages arise out of or are based upon any Violation, in each case, to
the extent, and only to the extent, that such Violation occurs in reliance upon and in conformity with written information relating to
the Investor furnished to the Company by the Investor expressly for use in connection with such Registration Statement, the Prospectus
included therein or any Prospectus Supplement thereto (it being hereby acknowledged and agreed that the written information set forth
on Exhibit A attached hereto is the only written information furnished to the Company by or on behalf of the Investor expressly
for use in any Registration Statement, Prospectus or Prospectus Supplement); and, subject to Section 6(c) and the below provisos in this
Section 6(b), the Investor shall reimburse a Company Party any legal or other expenses reasonably incurred by such Company Party in connection
with investigating or defending any such Claim; provided, however, the indemnity agreement contained in this Section 6(b) and the
agreement with respect to contribution contained in Section 7 shall not apply to amounts paid in settlement of any Claim if such settlement
is effected without the prior written consent of the Investor, which consent shall not be unreasonably withheld or delayed; and provided,
further, that the Investor shall be liable under this Section 6(b) for only that amount of a Claim or Indemnified Damages as does
not exceed the net proceeds to the Investor as a result of the applicable sale of Registrable Securities pursuant to such Registration
Statement, Prospectus or Prospectus Supplement. Such indemnity shall remain in full force and effect regardless of any investigation made
by or on behalf of such Company Party.

 

(c) Promptly after receipt by an Investor Party or Company Party (as
the case may be) under this Section 6 of notice of the commencement of any action or proceeding (including, without limitation, any governmental
action or proceeding) involving a Claim, such Investor Party or Company Party (as the case may be) shall, if a Claim in respect thereof
is to be made against any indemnifying party under this Section 6, deliver to the indemnifying party a written notice of the commencement
thereof, and the indemnifying party shall have the right to participate in, and, to the extent the indemnifying party so desires, jointly
with any other indemnifying party similarly noticed, to assume control of the defense thereof with counsel mutually satisfactory to the
indemnifying party and the Investor Party or the Company Party (as the case may be); provided, however, an Investor Party or Company
Party (as the case may be) shall have the right to retain its own counsel with the fees and expenses of such counsel to be paid by the
indemnifying party if: (i) the indemnifying party has agreed in writing to pay such fees and expenses; (ii) the indemnifying party shall
have failed promptly to assume the defense of such Claim and to employ counsel reasonably satisfactory to such Investor Party or Company
Party (as the case may be) in any such Claim; or (iii) the named parties to any such Claim (including, without limitation, any impleaded
parties) include both such Investor Party or Company Party (as the case may be) and the indemnifying party, and such Investor Party or
such Company Party (as the case may be) shall have been advised by counsel that a conflict of interest is likely to exist if the same
counsel were to represent such Investor Party or such Company Party and the indemnifying party (in which case, if such Investor Party
or such Company Party (as the case may be) notifies the indemnifying party in writing that it elects to employ separate counsel at the
expense of the indemnifying party, then the indemnifying party shall not have the right to assume the defense thereof on behalf of the
indemnified party and such counsel shall be at the expense of the indemnifying party, provided, further, that in the case of clause
(iii) above the indemnifying party shall not be responsible for the reasonable fees and expenses of more than one (1) separate legal counsel
for all Investor Parties or Company Parties (as the case may be). The Company Party or Investor Party (as the case may be) shall reasonably
cooperate with the indemnifying party in connection with any negotiation or defense of any such action or Claim by the indemnifying party
and shall furnish to the indemnifying party all information reasonably available to the Company Party or Investor Party (as the case may
be) which relates to such action or Claim. The indemnifying party shall keep the Company Party or Investor Party (as the case may be)
reasonably apprised at all times as to the status of the defense or any settlement negotiations with respect thereto. No indemnifying
party shall be liable for any settlement of any action, claim or proceeding effected without its prior written consent; provided, however,
the indemnifying party shall not unreasonably withhold, delay or condition its consent. No indemnifying party shall, without the prior
written consent of the Company Party or Investor Party (as the case may be), consent to entry of any judgment or enter into any settlement
or other compromise which does not include as an unconditional term thereof the giving by the claimant or plaintiff to such Company Party
or Investor Party (as the case may be) of a release from all liability in respect to such Claim or litigation, and such settlement shall
not include any admission as to fault on the part of the Company Party. For the avoidance of doubt, the immediately preceding sentence
shall apply to Sections 6(a) and 6(b) hereof. Following indemnification as provided for hereunder, the indemnifying party shall be subrogated
to all rights of the Company Party or Investor Party (as the case may be) with respect to all third parties, firms or corporations relating
to the matter for which indemnification has been made. The failure to deliver written notice to the indemnifying party within a reasonable
time of the commencement of any such action shall not relieve such indemnifying party of any liability to the Investor Party or Company
Party (as the case may be) under this Section 6, except to the extent that the indemnifying party is materially and adversely prejudiced
in its ability to defend such action.

 

    9

     

    

 

(d) No Person involved in the sale of Registrable Securities who is
guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the Securities Act) in connection with such sale shall
be entitled to indemnification from any Person involved in such sale of Registrable Securities who is not guilty of fraudulent misrepresentation.

 

(e) The indemnification required by this Section 6 shall be made by
periodic payments of the amount thereof during the course of the investigation or defense, as and when bills are received or Indemnified
Damages are incurred; provided that any Person receiving any payment pursuant to this Section 6 shall promptly reimburse the Person making
such payment for the amount of such payment to the extent a court of competent jurisdiction determines that such Person receiving such
payment was not entitled to such payment.

 

(f) The indemnity and contribution agreements contained herein shall
be in addition to (i) any cause of action or similar right of the Company Party or Investor Party against the indemnifying party or others,
and (ii) any liabilities the indemnifying party may be subject to pursuant to the law.

7. Contribution.

 

To the extent any indemnification by an indemnifying party is prohibited
or limited by law, the indemnifying party agrees to make the maximum contribution with respect to any amounts for which it would otherwise
be liable under Section 6 to the fullest extent permitted by law; provided, however: (i) no contribution shall be made under circumstances
where the maker would not have been liable for indemnification under the fault standards set forth in Section 6 of this Agreement, (ii)
no Person involved in the sale of Registrable Securities which Person is guilty of fraudulent misrepresentation (within the meaning of
Section 11(f) of the Securities Act) in connection with such sale shall be entitled to contribution from any Person involved in such sale
of Registrable Securities who was not guilty of fraudulent misrepresentation; and (iii) contribution by any seller of Registrable Securities
shall be limited in amount to the amount of net proceeds received by such seller from the applicable sale of such Registrable Securities
pursuant to such Registration Statement. Notwithstanding the provisions of this Section 7, the Investor shall not be required to contribute,
in the aggregate, any amount in excess of the amount by which the net proceeds actually received by the Investor from the applicable sale
of the Registrable Securities subject to the Claim exceeds the amount of any damages that the Investor has otherwise been required to
pay, or would otherwise be required to pay under Section 6(b), by reason of such untrue or alleged untrue statement or omission or alleged
omission.

8. Reports Under
the Exchange Act.

 

With a view to making available to the Investor the benefits of Rule
144, the Company agrees to:

 

(a) use its reasonable best efforts to make and keep public information
available, as those terms are understood and defined in Rule 144;

 

(b) use its reasonable best efforts to file with the Commission in
a timely manner all reports and other documents required of the Company under the Securities Act and the Exchange Act so long as the Company
remains subject to such requirements (it being understood that nothing herein shall limit any of the Company’s obligations under
the Purchase Agreement) and the filing of such reports and other documents is required for the applicable provisions of Rule 144;

 

(c) furnish to the Investor, so long as the Investor owns Registrable
Securities, promptly upon request, (i) a written statement by the Company, if true, that it has complied with the reporting, submission
and posting requirements of Rule 144 and the Exchange Act, (ii) a copy of the most recent annual or quarterly report of the Company and
such other reports and documents so filed by the Company with the Commission if such reports are not publicly available via EDGAR, and
(iii) such other information as may be reasonably requested to permit the Investor to sell such securities pursuant to Rule 144 without
registration; and

 

(d) take such additional action as is reasonably requested by the Investor
to enable the Investor to sell the Registrable Securities pursuant to Rule 144, including, without limitation, delivering all such legal
opinions, consents, certificates, resolutions and instructions to the Company’s Transfer Agent without unreasonable delay as may
be reasonably requested from time to time by the Investor and otherwise fully cooperate with Investor and Investor’s broker in their
efforts to effect such sale of securities pursuant to Rule 144.

    10

     

    

9. Assignment
of Registration Rights.

 

Neither the Company nor the Investor shall assign this Agreement or
any of their respective rights or obligations hereunder.

10. Amendment
or Waiver.

 

No provision of this Agreement may be amended or waived by the parties
from and after the date that is one (1) Business Day immediately preceding the date of filing of the Initial Registration Statement with
the Commission. Subject to the immediately preceding sentence, no provision of this Agreement may be (i) amended other than by a written
instrument signed by both parties hereto or (ii) waived other than in a written instrument signed by the party against whom enforcement
of such waiver is sought. Failure of any party to exercise any right or remedy under this Agreement or otherwise, or delay by a party
in exercising such right or remedy, shall not operate as a waiver thereof.

11. Miscellaneous.

 

(a) Solely for purposes of this Agreement, a Person is deemed to be
a holder of Registrable Securities whenever such Person owns or is deemed to own of record such Registrable Securities. If the Company
receives conflicting instructions, notices or elections from two or more Persons with respect to the same Registrable Securities, the
Company shall act upon the basis of instructions, notice or election received from such record owner of such Registrable Securities.

 

(b) Any notices, consents, waivers or other communications required
or permitted to be given under the terms of this Agreement shall be given in accordance with Section 10.4 of the Purchase Agreement.

 

(c) Failure of any party to exercise any right or remedy under this
Agreement or otherwise, or delay by a party in exercising such right or remedy, shall not operate as a waiver thereof. The Company and
the Investor acknowledge and agree that irreparable damage would occur in the event that any of the provisions of this Agreement were
not performed in accordance with their specific terms or were otherwise breached. It is accordingly agreed that either party shall be
entitled to an injunction or injunctions to prevent or cure breaches of the provisions of this Agreement by the other party and to enforce
specifically the terms and provisions hereof (without the necessity of showing economic loss and without any bond or other security being
required), this being in addition to any other remedy to which either party may be entitled by law or equity.

 

(d) All questions concerning the construction, validity, enforcement
and interpretation of this Agreement shall be governed by the internal laws of the State of New York, without giving effect to any choice
of law or conflict of law provision or rule (whether of the State of New York or any other jurisdictions) that would cause the application
of the laws of any jurisdictions other than the State of New York. Each party hereby irrevocably submits to the exclusive jurisdiction
of the federal courts sitting in The City of New York, Borough of Manhattan, for the adjudication of any dispute hereunder or in connection
herewith or with any transaction contemplated hereby or discussed herein, and hereby irrevocably waives, and agrees not to assert in any
suit, action or proceeding, any claim that it is not personally subject to the jurisdiction of any such court, that such suit, action
or proceeding is brought in an inconvenient forum or that the venue of such suit, action or proceeding is improper. Each party hereby
irrevocably waives personal service of process and consents to process being served in any such suit, action or proceeding by mailing
a copy thereof to such party at the address for such notices to it under this Agreement and agrees that such service shall constitute
good and sufficient service of process and notice thereof. Nothing contained herein shall be deemed to limit in any way any right to serve
process in any manner permitted by law. If any provision of this Agreement shall be invalid or unenforceable in any jurisdiction, such
invalidity or unenforceability shall not affect the validity or enforceability of the remainder of this Agreement in that jurisdiction
or the validity or enforceability of any provision of this Agreement in any other jurisdiction. EACH PARTY HEREBY IRREVOCABLY WAIVES ANY
RIGHT IT MAY HAVE TO, AND AGREES NOT TO REQUEST, A JURY TRIAL FOR THE ADJUDICATION OF ANY DISPUTE HEREUNDER OR IN CONNECTION HEREWITH
OR ARISING OUT OF THIS AGREEMENT OR ANY TRANSACTION CONTEMPLATED HEREBY.

 

    11

     

    

 

(e) The Transaction Documents set forth the entire agreement and understanding
of the parties solely with respect to the subject matter thereof and supersedes all prior and contemporaneous agreements, negotiations
and understandings between the parties, both oral and written, solely with respect to such matters. There are no promises, undertakings,
representations or warranties by either party relative to the subject matter hereof not expressly set forth in the Transaction Documents.
Notwithstanding anything in this Agreement to the contrary and without implication that the contrary would otherwise be true, nothing
contained in this Agreement shall limit, modify or affect in any manner whatsoever (i) the conditions precedent to a VWAP Purchase contained
in Article VII of the Purchase Agreement or (ii) any of the Company’s obligations under the Purchase Agreement.

 

(f) This Agreement shall inure to the benefit of and be binding upon
the parties hereto and their respective successors. This Agreement is not for the benefit of, nor may any provision hereof be enforced
by, any Person, other than the parties hereto, their respective successors and the Persons referred to in Sections 6 and 7 hereof (and
in such case, solely for the purposes set forth therein).

 

(g) The headings in this Agreement are for convenience of reference
only and shall not limit or otherwise affect the meaning hereof. Unless the context clearly indicates otherwise, each pronoun herein shall
be deemed to include the masculine, feminine, neuter, singular and plural forms thereof. The terms “including,” “includes,”
“include” and words of like import shall be construed broadly as if followed by the words “without limitation.”
The terms “herein,” “hereunder,” “hereof” and words of like import refer to this entire Agreement
instead of just the provision in which they are found.

 

(h) This Agreement may be executed in two or more identical counterparts,
all of which shall be considered one and the same agreement and shall become effective when counterparts have been signed by each party
and delivered to the other party; provided that a facsimile signature or signature delivered by e-mail in a “.pdf” format
data file, including any electronic signature complying with the U.S. federal ESIGN Act of 2000, e.g., www.docusign.com, www.echosign.adobe.com,
etc., shall be considered due execution and shall be binding upon the signatory thereto with the same force and effect as if the signature
were an original signature.

 

(i) Each party shall do and perform, or cause to be done and performed,
all such further acts and things, and shall execute and deliver all such other agreements, certificates, instruments and documents as
any other party may reasonably request in order to carry out the intent and accomplish the purposes of this Agreement and the consummation
of the transactions contemplated hereby.

 

(j) The language used in this Agreement will be deemed to be the language
chosen by the parties to express their mutual intent and no rules of strict construction will be applied against any party.

 

12. Termination.

 

This Agreement shall terminate in its entirety upon the earlier of
(i) the date on which the Investor shall have sold all of, or otherwise no longer holds any of, the Registrable Securities and (ii) the
Purchase Agreement shall have or been terminated in accordance with its terms; provided, however, that the provisions of Sections
4, 6, 7, 9, 10 and 11 shall remain in full force and effect.

 

[Signature Pages Follow]

 

    12

     

    

 

IN WITNESS WHEREOF, the Investor and the Company have caused
their respective signature page to this Registration Rights Agreement to be duly executed as of the date first written above.

 

	 	COMPANY:
	 	 
	 	BIOTECH ACQUISITION COMPANY
	 	 	 
	 	By:	/s/ Albert F.
    Hummel
	 	 	Name: Albert F. Hummel
	 	 	Title:
    Chief Investment Officer and Director

 

[Signature Page to Registration Rights Agreement]

 

     

     

    

 

IN WITNESS WHEREOF, the Investor and the Company have caused
their respective signature page to this Registration Rights Agreement to be duly executed as of the date first written above.

 

	 	INVESTOR:
	 	 
	 	CF PRINCIPAL INVESTMENTS LLC
	 	 	 
	 	By:	/s/ Mark
    Kaplan
	 	 	Name: Mark Kaplan
	 	 	Title: Chief Operating Officer

 

[Signature Page to Registration Rights Agreement]

 

     

     

    

 

EXHIBIT A 

 

CF Group Management, Inc. (“CFGM”) is the managing general
partner of Cantor Fitzgerald, L.P. (“CFLP”) and directly or indirectly controls the managing general partner of Cantor Fitzgerald
Securities (“CFS”), the sole member of CF Principal Investments LLC (“Cantor”). Howard W. Lutnick is Chairman
and Chief Executive of CFGM and trustee of CFGM’s sole stockholder. CFLP, indirectly, holds a majority of the ownership interests
in CFS, and therefore also indirectly, Cantor. As such, each of CFLP, CFGM, CFS and Mr. Lutnick may be deemed to have beneficial ownership
of the securities directly held by Cantor. Each such entity or person disclaims any beneficial ownership of the reported shares other
than to the extent of any pecuniary interest they may have therein, directly or indirectly. The foregoing should not be construed in and
of itself as an admission by any of CFLP, CFGM, CFS or Mr. Lutnick as to beneficial ownership of the securities beneficially owned, directly,
by Cantor. The business address of Cantor is 110 East 59th Street, New York, NY 10022.Exhibit 10.1

EXECUTION COPY

March 23, 2022
​
Ali Dibadj
Via email
​
Dear Ali:
​
Janus Henderson Group plc (the “Company” or “JHG”) is pleased to extend an offer of employment to you for the position of Chief Executive Officer of the Company.  We are committed to setting ourselves apart from other employers to retain our talent and reward your contributions to our firm. One way we accomplish this is by offering a competitive, yet flexible, Total Rewards package that includes base salary, performance-based variable compensation, retirement contributions, medical, dental and life insurance – in addition to a wide range of employee programs and services.  We know that what sets us apart sets our clients apart and we are excited to introduce you to our unique organization.  
On behalf of the Company, I am pleased to extend to you an offer of employment with the Company on the following terms and conditions:

1.Role and Term. You will serve as our Chief Executive Officer (“CEO”), report to the Company’s Board of Directors (“Board”) and have such duties, responsibilities and authorities as are commensurate with the role of a CEO. We would like your employment to start as soon as possible on a mutually agreed upon date to be determined, but no later than June 27, 2022 (the date employment with the Company commences, “Start Date”). Your employment will be for an initial term of three years (ending on the third anniversary of your Start Date) (“Initial Term”), with the ability to extend for additional periods as agreed upon by you and the Board.  You will be employed by Janus Henderson Investors US LLC, a subsidiary of the Company (“JHI” and, together with the Company and its affiliates, the “Group”).
​
2.Base Salary.  You will be compensated $30,208.34 per semi-monthly pay period; this is equivalent to $725,000.16 on an annualized basis.  Your base salary will be reviewed annually for increase and it and all other compensation from the Group is subject to legally-required and employee-authorized withholdings and payable in accordance with JHI’s standard payroll practices.  
​
3.Variable Compensation.  As an employee of the Group, you will be eligible to participate in annual discretionary variable compensation opportunities, beginning in 2022, per the terms of the variable compensation program.  Variable compensation is determined on an annual basis and is discretionary, depending on both Group and individual performance as determined by the Compensation Committee of the Board (the “Compensation Committee”), using a balanced scorecard approach.  Annual variable compensation is currently apportioned as 30% cash and 70% deferred equity awards 

 ​

​

EXECUTION COPY

(“Deferrals”).  Deferrals will be awarded in the form of restricted stock units and performance share units. This structure is subject to change at any time with or without notice at the discretion of the Compensation Committee.  Deferred awards and cash bonuses are generally paid/distributed during the first quarter of each calendar year (for performance in the previous calendar year), and are subject to the Group’s policies related to malus and clawback.  Time-based deferred awards vest ratably over three years and performance share units generally cliff vest at the end of three years based on achievement of relevant performance measures, in either case, subject to continued employment with the Group through the applicable vesting date.   For 2022, your variable compensation will be guaranteed at $8,500,000. For each year during the Initial Term, the targeted value of the cash portion of your variable compensation shall be no less than $2,550,000 (“Target Cash Bonus”).
​
		4.	One-Time Hire Award. We are also pleased to offer you a one-time new hire award (“Hire Award”) in the form of JHG restricted stock units with a total grant date value of $5,000,000.  The Hire Award will vest in equal installments over the first three years following the date of grant, subject to your continued employment with the Group through each vesting date or in accordance with provisions on termination of employment in the Severance Rights Agreement. The Hire Award will be made to you on the later of your Start Date or immediately following the Annual General Meeting and in accordance with the DIP granting procedures.  To the extent the date that would have otherwise been the grant date falls in a closed trading period, the grant date will be the first day following the end of the closed period.  The Hire Award will be subject to the Group’s policies related to deferrals, malus and clawback as described herein. 

​
		5.	Benefits.  As an employee of the Group, you will be eligible to participate in JHI’s flexible benefits program as of the first day of the month following your start date.  This comprehensive program includes: medical, dental, vision, term life, and disability insurances, as well as many other innovative programs.  At your convenience, we will schedule a personal New Employee Orientation where we will provide you with information about our company, our flexible benefits, and many other programs.  Your eligibility to participate in the JHI 401(k) program begins the payroll cycle following your hire date.  You shall also be eligible for all perquisites provided to other senior executives of the Group and travel (including travel to and from Denver and London) and reimbursement policies commensurate with your role and no less favorable than those provided to other senior executives of the Group.

​
		6.	Employment and Company Policies. Your employment with the Group is at-will and either you or the Group may terminate the relationship at any time without cause.  Either party will be required to give the other party at least three months prior written notice of termination of your employment.   You represent that there are no contractual or other legal restrictions on your ability to accept this offer and, as of the Start Date, fully perform your duties on behalf of the Group.  If you accept this offer, you will be expected to comply with the Group’s current Employee Policies and Guidelines, as they may be amended from time to time, and to sign an acknowledgment stating you have received and read the 

‌2

​

EXECUTION COPY

			Employee Policies and Guidelines, provided that, except as required by applicable law (including United States securities laws), governmental regulation, remuneration code requirements, or stock exchange listing requirements, for purposes of any plan or arrangement of the Group in which you participate, (x) the definition of "cause" in any such plan or arrangement as applicable to you shall be the definition of Cause in the Severance Rights Agreement and (y) any forfeiture (malus) or claw-back provision applicable to you shall be substantially comparable to those in effect as of the date hereof.  The Group companies under JHG will not maintain existing or sponsor new industry registrations or licenses where not supported by an employee’s job functions (as determined by the Company at its sole discretion). As the CEO, your employment is subject to the acceptance of your application for registration by the Financial Conduct Authority (FCA). In view of this, we will schedule a separate discussion to review your role and obligations and assist you throughout the process.

​
		7.	Employment Location. Your primary work location will be determined at a future date as mutually agreed. In the event that you are required to relocate, you will be eligible for the benefits outlined in our Executive Relocation Package. As part of your relocation package, the Group shall reimburse you for your reasonable expenses in relocating, subject to a repayment agreement if you resign your employment without Good Reason (as defined in the Severance Rights Agreement) within one year following your relocation. Further information will be provided at the time of your move.

​
		8.	Service on Boards. During the term of your employment, in addition to performing the role of CEO, you will serve as a member of the Company’s Board or other Company-related boards if nominated to that role.  You shall devote your full professional time and attention to the business and affairs of the Company to discharge the responsibilities of a CEO, provided that, notwithstanding the foregoing, you shall be permitted, without any approval to serve on civil or charitable boards or committees and to manage personal and family investments, in each case, so long as such activities do not (x) interfere with the performance of your responsibilities to the Company or (y) violate Section 5 of the Severance Rights Agreement. Board approval is required to serve on any corporate board on which you do not currently serve, with the ability to serve on only one such public company board.  In serving on such other public company board, you will resign from such board if requested to do so by the Board. It is acknowledged and agreed that, as of the date hereof, you serve as a member of Sysco Corporation and that such service does not violate the terms of this paragraph.

​
		9.	Severance. If your employment is terminated by the Group prior to the end of your Initial Term without “Cause” (as defined in the DIP) or you resign for “Good Reason” (as defined in the Severance Rights Agreement), you will receive, in one lump sum, 3.0 times your annual total cash compensation (which, for the avoidance of doubt, includes your base salary and the Target Cash Bonus), provided that in the event that the termination occurs prior to the payment of the guaranteed amount for 2022, your annual total cash compensation shall be deemed to be $3,275,000.16.  In addition, any unvested restricted stock units will continue to vest in accordance with the vesting schedules outlined in the 

‌3

​

EXECUTION COPY

			award agreement and related plans.  These matters will be addressed in and subject to a Severance Rights Agreement between you and JHI which will be entered into on your Start Date in substantially the form attached hereto. No severance will be paid to you if your employment is terminated for Cause or if you voluntarily resign, and the Group will have no further obligation to provide compensation or benefits to you by reason of such terminations.

​
		10.	Indemnification. The Company shall indemnify and hold you harmless (including advancement of expenses) to the fullest extent permitted by law, and shall cover you under any insurance policy the Company maintains for the errors and omissions of its directors and officers, in connection with your service as an officer and director of the Company and at coverage levels appropriate for the Company and your positions with the Group (as determined from time to time by the Board) and consistent with levels provided to and expenses covered for all other directors and officers of the Company. Such indemnification and coverage shall survive termination of your employment and/or this Agreement. 

​
		11.	Sections 7 through 15 of the Severance Rights Agreement shall be incorporated herein by reference mutatis mutandis

​
​
*  *  *  *
​
​

‌4

​

EXECUTION COPY

Please sign below to confirm your acceptance of the terms of this offer.   We are delighted at the prospect of working with you.
​
​
	

	

	

	Sincerely,

	 
	 
	 

	JANUS HENDERSON GROUP PLC

	 
	 
	 

	By:_____________________________
	 
	 

	 
	​
	​

	Name: 

	Title:

	 
	 
	 

	Agreed and Accepted:

	 
	 
	 

	By: _________________________________
       Ali Dibadj
​
	 
	 

	 
	​
	​

	
	 
	 
	 

	Date:

​

‌5

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00344-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00344-of-00352.parquet"}]]