Document:

Prepared by MerrillDirect

SUBLEASE

          THIS
SUBLEASE (this “Sublease”) is dated for reference purposes as of
March 30, 2001, and is made by and between CYGNUS, INC.,a
Delaware corporation (“Sublandlord”), and MAXYGEN, INC., a Delaware corporation
(“Subtenant”).  Sublandlord and Subtenant
hereby agree as follows:

          1.       Recitals:  This Sublease is made with reference to the
fact that Seaport Center Venture Phase I, a California General Partnership, as
landlord, and Sublandlord, as tenant, are parties to that certain Lease dated
September 27, 1988 (“Original Lease”), and all Schedules, Riders (including
Rider No. 1 to Seaport Center Standard Lease) and Exhibits thereto, as such
Lease has been amended by amendments dated May 15, 1992 (“First Amendment”),
August 8, 1992 (“Second Amendment”) and June 9, 1998 (“Third Amendment”)
(herein collectively referred to as the “Master Lease”), with respect to those
certain “Premises” leased by Sublandlord as described in the Master Lease
(herein referred to as the “Premises”), which Premises constitute 32,038 square
feet of space consisting of two (2) buildings commonly known as 701 Galveston
Street and 501 Chesapeake Drive, Redwood City, California, as more particularly
described in the Master Lease (collectively referred to as the “Buildings” and
individually referred to as a “Building”). Metropolitan Life Insurance Company,
a New York corporation (“Master Landlord”), is a successor-in-interest to
Seaport Venture Phase I and is currently the landlord under the Master Lease.  A copy of the Master Lease is attached
hereto as Exhibit “A” and Subtenant acknowledges receipt thereof.  Capitalized terms used and not defined
herein shall have the meaning ascribed to them in the Master Lease, whether or
not such term is expressly incorporated herein pursuant to Section 18(a) of
this Sublease.

          2.       Subleased
Premises:  Subject to the terms and
conditions of this Sublease, Sublandlord hereby subleases to Subtenant, and
Subtenant hereby subleases from Sublandlord, a portion of the Premises agreed
by the parties to be approximately 11,158 rentable square feet in the Building
(the “501 Building”) commonly known as 501 Chesapeake Drive, Redwood City,
California (whether or not actually 11,158 rentable square feet) as more
particularly described on Exhibit “B” attached hereto and incorporated
herein by reference (the “Subleased Premises”).

          3.       Term:

                    (a)     Term;
Early Access:  The term (the “Term”)
of this Sublease shall be for the period commencing on the later of (a) May 1,
2001 or (b) the date of Master Landlord’s written consent to this Sublease (the
“Sublease Commencement Date”) and ending December 10, 2003, unless this
Sublease is sooner terminated pursuant to its terms or the Master Lease is
sooner terminated for any reason (the “Expiration Date”).  Subtenant shall have the right of access to
the Subleased Premises during business hours, subject to all of the provisions
of this Sublease other than payment of Rent (as defined in Paragraph 4(a)
below), at any time between the date of Master Landlord’s written consent to this
Sublease and the Sublease Commencement Date solely for the purposes of
performing measurements and space planning, but not for any construction of
alterations, provided that Subtenant shall give Sublandlord reasonable notice
in advance of accessing the Subleased Premises and shall not interfere with the
activities of Sublandlord within the Subleased Premises or the activities of
any tenant or other occupant of the 501 Building.

                    (b)     Delay in Delivery and Acceptance; Termination:  This Sublease
shall not be void or voidable
nor shall Sublandlord be liable to Subtenant for any loss or damage by reason
of delay in the Sublease Commencement Date or delay in Sublandlord delivering
possession of the Subleased Premises to Subtenant for any reason whatsoever; provided,
however, that Rent shall abate until Sublandlord delivers possession of the
Subleased Premises to Subtenant and Subtenant shall have the right to terminate
this Sublease by written notice to Sublandlord if Sublandlord does not deliver
possession of the Subleased Premises within five (5) days after the Sublease
Commencement Date.  If Subtenant
delivers such written notice of termination to Sublandlord within ten (10) days
after the expiration of said five (5) day period, neither Sublandlord nor Subtenant
shall have any further liability or obligation to the other under or by reason
of this Sublease except that Sublandlord shall return to Subtenant any prepaid
Base Rent and Security Deposit received by Sublandlord.  Subtenant has fully inspected the Subleased
Premises and is satisfied with the condition thereof.  Subtenant’s taking possession of the Subleased Premises shall be
conclusive evidence that the Subleased Premises were in good order and
satisfactory condition when Subtenant took possession.

          4.       Rent:

                    (a)     Base
Rent:  Commencing on the Sublease
Commencement Date and continuing on the first (1st) day of each calendar month
throughout the Term, Subtenant shall pay to Sublandlord base rent for the
Subleased Premises in monthly installments of Thirty Six Thousand Eight Hundred
Twenty One Dollars and 40/100ths Dollars ($36,821.40) (“Base Rent”); provided,
however, that Subtenant shall not be required to pay the installment of Base
Rent due for the first full calendar month of the Term.  Base Rent, Additional Rent (as defined in
Section 4(b) below) and any other charge or sum payable by Subtenant pursuant
to this Sublease are collectively hereinafter referred to as “Rent”.  Base Rent shall be paid in advance on the
Sublease Commencement Date and thereafter on or before the first (1st) day of
each month during the Term.  Rent for
any period during the Term which is for less than one (1) full calendar month
shall be a pro rata portion of the monthly installment based on a thirty (30)
day month.  Rent shall be payable
without notice or demand and without any deduction, offset, counterclaim, or
abatement, in lawful money of the United States of America.  Rent shall be paid directly to Sublandlord
at Cygnus, Inc., 400 Penobscot Drive, Redwood City, California 94063, Attn:
Finance Department, or such other address as may be designated in writing by
Sublandlord.

                    (b)     Additional
Rent:  Commencing on the Sublease
Commencement Date and continuing throughout the Term, Subtenant shall pay to
Sublandlord as additional rent (“Additional Rent”):

                              (1)     The
following percentages (“Subtenant’s Share”) of the Operating Expenses (as
defined below) payable by Sublandlord pursuant to the Master Lease:

 

	Type of Expense

	Subtenant’s Share

	Building Operating Expenses for 501 Building	100%
	Project Operating Expenses	34.8%
	Phase Operating Expenses	34.8%

 

                              (2)     Thirty
four and eight-tenths percent (34.8%) of all Utilities (as defined below)
payable by Sublandlord with respect to the Project and Phase I, plus one
hundred percent (100%) of the Utilities, if any, payable by Sublandlord with
respect to the 501 Building.

                    (c)     Definition
of Operating Expenses and Utilities: 
As used in this Sublease, Operating Expenses shall mean those “operating
expenses” (including, without limitation, “Building Operating Expenses”,
“Project Operating Expenses”, and “Phase Operating Expenses”) as defined and
described in Paragraph 7 of the Original Lease and Section 6 of the Third
Amendment; provided, however, that Operating Expenses shall not include any
Building Operating Expenses (as defined in Section 6(v) of the Third Amendment)
attributable to any specific Building other than the 501 Building (unless they
constitute Phase Operating Expenses). 
As used in this Sublease, Utilities shall mean the “utilities” as
defined and described in Paragraph 8 of the Original Lease, Section 6(c) of the
Second Amendment and Section 7 of the Third Amendment; provided, however, that
Utilities shall not include any utilities separately metered to the Subleased Premises
or any utilities attributable to any specific Building other than the 501
Building (unless they constitute Phase Operating Expenses).

                    (d)     Operating
Expenses Based on Master Landlord Statements:  Notwithstanding Sections 4(b) or (c) above, the parties
acknowledge that Master Landlord currently bills Sublandlord for Operating
Expenses on a lump sum basis (i.e., without itemizing the Operating
Expenses).  Notwithstanding anything to
the contrary in Sections 4(b) or (c) above, the parties agree that so long as
the Master Landlord bills Sublandlord on a lump sum basis, Subtenant shall pay
to Sublandlord as Additional Rent thirty four and eight-tenths percent (34.8%)
of the amount for Operating Expenses shown on the billing statement received by
Sublandlord from Master Landlord, subject to annual adjustments necessitated by
the annual reconciliation of operating expenses by Master Landlord pursuant to
the Master Lease. Sublandlord and Subtenant agree that should Master Landlord
at any time during Term of this Sublease provide Sublandlord with a breakdown
of the Operating Expenses that specifically allocates such expenses to Building
Operating Expenses, Project Operating Expenses or Phase Operating Expenses or a
breakdown of the Utilities that specifically allocates such Utilities to
Building Utilities, Project Utilities, or Phase Utilities, then Subtenant shall
pay Subtenant’s Share of such Operating Expenses or Utilities as provided in
Sections 4(b) and 4(c) above and, to the extent that such breakdown covers
Operating Expenses or Utilities previously paid by Subtenant to Sublandlord,
the parties shall credit or debit Subtenant for any over- or underpayment of
Subtenant’s Share. Subtenant shall promptly pay to Sublandlord any sums so
debited to Subtenant.

                    (e)     Payment of Additional Rent:  Subtenant shall pay Sublandlord
all items of Additional Rent not
later than the later to occur of (a) five (5) days before the date the
analogous item of Additional Rent is due under the Master Lease or (b) five (5)
days after Sublandlord’s delivery of written demand therefor to Subtenant.  Notwithstanding anything to the contrary in
this Sublease, Subtenant shall not be required to pay (i) any Additional Rent
that is fairly allocable to any period of time prior to the Sublease
Commencement Date or (ii) late charges or penalties payable to Master Landlord
as a result of a default by Sublandlord of any of its obligations under the
Master Lease (except to the extent such default is the result of a default by
Subtenant of any of its obligations under this Sublease).

          5.       Security
Deposit:  Upon execution hereof,
Subtenant shall deposit with Sublandlord the sum of Thirty Six Thousand Eight
Hundred Twenty One and 40/100ths Dollars ($36,821.40) (the “Security Deposit”),
in cash, as security for the performance by Subtenant of the terms and
conditions of this Sublease.  If
Subtenant fails to pay Rent or other charges due under this Sublease or
otherwise defaults beyond applicable notice and cure periods with respect to
any provision of this Sublease, then Sublandlord may draw upon, use, apply or
retain all or any portion of the Security Deposit for the payment of any Rent
or other charge or obligation in default, for the payment of any other sum
which Sublandlord has become obligated to pay by reason of Subtenant’s default,
or to compensate Sublandlord for any loss or damage which Sublandlord has
suffered by reason of Subtenant’s default (including, without limitation,
damage to the Subleased Premises).  If
Sublandlord so uses or applies all or any portion of the Security Deposit, then
Subtenant, within ten (10) days after demand by Sublandlord therefor, shall
deposit cash with Sublandlord in the amount required to restore the Security
Deposit to the full amount stated above. 
Sublandlord may commingle the Security Deposit with its own funds and
Subtenant shall not be entitled to interest on the Security Deposit.  Upon the expiration or earlier termination
of this Sublease and Subtenant’s vacation of the Subleased Premises,
Sublandlord shall return to Subtenant so much of the Security Deposit as has
not been applied by Sublandlord pursuant to this paragraph or which is not
otherwise required to cure Subtenant’s defaults.

          6.       Holdover:
Subtenant acknowledges that it is critical that Subtenant surrender the
Subleased Premises on or before the Expiration Date in accordance with the
terms of this Sublease.  Accordingly,
Subtenant shall indemnify, defend and hold harmless Sublandlord from and
against any and all losses, costs, claims, liabilities and damages resulting
from Subtenant’s failure to surrender the Subleased Premises on the Expiration
Date in the condition required under the terms of this Sublease (including,
without limitation, any and all liability or damages sustained by Sublandlord
as a result of a holdover of the Subleased Premises by Sublandlord occasioned
by the holdover of the Subleased Premises by Subtenant).  The foregoing indemnity shall survive the
expiration or sooner termination of this Sublease. Subtenant has no right to
retain possession of the Subleased Premises or any part thereof beyond the
Expiration Date or sooner termination of this Sublease.  If Subtenant remains in possession of the
Subleased Premises or any part thereof after the Expiration Date or sooner
termination of this Sublease, such occupancy shall be a tenancy-at-sufferance
at the Base Rent in effect during the month immediately preceding the
expiration or termination, together with all other sums comprising Rent
hereunder, and otherwise subject to all the provisions of this Sublease.  Nothing contained herein shall be construed
as consent by Sublandlord to any holding over by Subtenant or as a limitation
of Subtenant’s rights and remedies should Subtenant hold over.

          7.       “AS-IS”; Repairs:  Subtenant acknowledges and agrees that
Subtenant is subleasing the Subleased Premises on an “AS-IS” basis in its
current “AS-IS” condition (except that the Premises shall be delivered broom
clean) inclusive of all faults and defects. 
Subtenant further acknowledges and agrees that except as expressly
provided below, Sublandlord has made no representations or warranties, express
or implied, whatsoever, with respect to the Subleased Premises (including,
without limitation, any representation or warranty as to fitness, habitability,
or suitability for Subtenant’s intended use or purposes).  Sublandlord represents that it (a) has not
received written notice of any building code violations applicable to the
Subleased Premises, and (b) the Subleased Premises and Sublandlord’s leased
premises at 701 Galveston are separately metered to Pacific Gas &
Electric.  Sublandlord shall have no
obligation whatsoever to make or pay the cost of any alterations, improvements
or repairs to the Subleased Premises including, without limitation, any
improvement or repair required to comply with any law, regulation, building
code or ordinance (including the Americans with Disabilities Act of 1990, as
amended).  In addition, Sublandlord
shall have no obligation to make or perform any repairs, maintenance,
replacements or other obligations required to be performed by Master Landlord
under the terms of the Master Lease or otherwise under the law.  Sublandlord shall, however, after receipt of
Subtenant’s written request, promptly notify Master Landlord of any
nonperformance of Master Landlord’s obligations under the Master Lease that is
claimed in Subtenant’s written notice, and request that Master Landlord perform
the same, and shall use Sublandlord’s commercially reasonable efforts (not
including the payment of money, the incurring of any liabilities, or the
institution of legal proceedings) to obtain Master Landlord’s performance
(collectively, “Sublandlord’s Master Lease Enforcement Obligations”).  Subtenant hereby waives the provisions of
Section 1932, subsection 1, and Sections 1941 and 1942 of the Civil Code of
California, including any rights as may exist under Section 1942 to make
repairs at the expense of Sublandlord.

          If by reason of casualty damage to or
destruction or condemnation of the Subleased Premises during the Term
Sublandlord has the right to terminate the Master Lease pursuant to Paragraphs
24 or 25 of the Master Lease and elects not to terminate the Master Lease
pursuant to said Paragraphs, Subtenant shall have the right to terminate this
Sublease on the same terms and conditions (and within the same time frame) that
Sublandlord has to terminate the Master Lease pursuant to said Paragraphs 24 or
25 with respect to the Subleased Premises. Sublandlord shall promptly provide
Subtenant with a copy of any notice of casualty damage submitted by Sublandlord
to Master Landlord pursuant to Paragraph 24 of the Master Lease and with a copy
of any notice received from Master Landlord pursuant to such Paragraph 24
regarding Master Landlord’s architect’s determinations with regard to such
casualty damage. If the rent payable by Sublandlord under the Master Lease with
respect to the Subleased Premises is abated by reason of Paragraphs 24 or 25 of
the Master Lease, the Rent payable by Subtenant hereunder for the period of
such abatement shall be abated on a proportionate basis.  Subtenant shall not be entitled to any
compensation or damages from Sublandlord or Master Landlord for loss of use of
the whole or any part of the Subleased Premises or any improvements, fixtures
or personal property of Subtenant, or for any inconvenience or annoyance
occasioned by condemnation, fire or other casualty damage to the Subleased
Premises or the 501 Building or any repair, reconstruction or restoration
performed in connection therewith. 
Sublandlord and Subtenant agree that the terms of this Sublease shall
govern the effect of any damage to or destruction or condemnation of the
Subleased Premises or the 501 Building with respect to the termination of this
Sublease and Subtenant hereby waives the provisions of any present or future
statute or rule of law to the extent it is inconsistent herewith.

          8.       Assignment and Subletting:  In addition to the provisions of Paragraph
15 of the Master Lease as incorporated herein (requiring, among other things,
Sublandlord’s consent to any proposed assignment or subletting, which consent
shall not be unreasonably withheld, subject to the provisions of said Paragraph
15), Subtenant shall not assign, pledge, encumber or otherwise transfer any
interest in this Sublease, sublet all or any part of the Subleased Premises,
transfer any interest of Subtenant therein or permit any use of the Subleased
Premises by another party (collectively, “Transfer”), without the prior written
consent of Master Landlord. Subtenant shall not be relieved from any of its
obligations under this Sublease by reason of any Transfer.

          9.       Use:  Subtenant shall use the Subleased Premises
as a bio-processing scale-up facility and such other purposes as are permitted
under the Master Lease and for no other purposes whatsoever.  Subtenant shall observe and comply with, and
cause all of its agents, employees, contractors, visitors, licensees,
subtenants, invitees, and assignees (collectively “Subtenant Parties”) to
comply with, all Rules promulgated by Master Landlord pursuant to the Master
Lease.  Neither Master Landlord nor
Sublandlord shall be liable for failure of any person to obey such Rules.  Nor shall Master Landlord be obligated to
enforce such Rules against any person. Attachment 1 to Rider No. 1 to the
Original Lease is hereby replaced and superceded in its entirety by Exhibit
“C” to this Sublease. Subtenant covenants and warrants that it shall not
use or permit any Subtenant Party to use any Hazardous Materials (as defined in
Paragraph 9 of the Original Lease and Rider No. 1 thereto) on the Subleased
Premises, the 501 Building or the Project, except for the use of Permitted
Hazardous Materials (as defined in Rider No. 1 to the Original Lease as
modified by this Sublease) in accordance with the terms of this Sublease
(including, without limitation, Rider No. 1 to the Original Lease as modified
by this Sublease).

          10.     Effect
of Conveyance:  As used in this
Sublease, the term “Sublandlord” means the holder of the Lessee’s interest
under the Master Lease.  Sublandlord may
transfer and deliver (by cash or credit) any security of Subtenant to the
transferee of the Lessee’s interest under the Master Lease, and thereupon
Sublandlord shall be discharged from any further liability with respect
thereto.

          11.     Alterations:
In addition to the requirements of Paragraph 11 of the Master Lease as
incorporated herein (requiring, among other things, Sublandlord’s consent,
which shall not be unreasonably withheld, subject to the provisions of said
Paragraph 11), Subtenant shall not make any additions, alterations,
improvements or other modifications to the Subleased Premises or any part
thereof except in accordance with the terms of the Master Lease and with the
prior written consent of Master Landlord. 
Without limiting the foregoing, Subtenant shall be responsible, at its
sole expense, for the installation, maintenance and repair of Subtenant’s
network connection to the existing network room at the Subleased Premises.  Subtenant shall, at its sole cost, make all
modifications, alterations and improvements to the Subleased Premises and the
501 Building that are required by any applicable local, state or federal rule,
law, regulation or order because of: 
(i) Subtenant’s particular use of the Subleased Premises or 501
Building; (ii) Subtenant’s application for any building permit or other
governmental approval; or (iii) Subtenant’s making of any alteration or
improvement to or within the Subleased Premises.

          12.     Insurance;
Exemption of Sublandlord from Liability.

                    (a)     Subtenant’s Liability Insurance.  Subtenant, at its sole
expense, shall obtain
and keep in full force and effect during the Term such insurance, in such
amounts, as are required to be obtained and kept by Lessee under Paragraph 20
of the Master Lease.  Without limiting
the foregoing, Subtenant shall, at its sole expense, cause Sublandlord and
Master Landlord to be named as additional insureds under the liability
policy(ies) required to be maintained by Subtenant.  Subtenant and Sublandlord shall each obtain from their respective
property insurers a waiver of all rights of subrogation as set forth in
Paragraph 19 of the Master Lease.  The
other waivers contained in Paragraph 19 of the Master Lease shall apply as
between Subtenant and Sublandlord.

                    (b)     Exemption
of Sublandlord from Liability. 
Sublandlord shall not be liable to Subtenant or anyone else for any
harm, injury (including illness and emotional distress), death or damage to (i)
the person or goods, wares, merchandise or other property of Subtenant, any
Subtenant Party, or any other person on or traveling to or from the Subleased
Premises, or (ii) Subtenant or its business, whether such damage or injury is
caused by or results from fire, steam, electricity, gas, water or rain, or from
the breakage, leakage, obstruction or other defects or pipes, fire sprinklers,
wires, appliances, plumbing, HVAC or lighting fixtures, or from any variation
or interruption of utility (including telecommunications) services, or from any
other cause, including where the said injury or damage results from
Sublandlord’s or its employees’, agents’, or contractors’ acts or omissions or
from any other sources or places, but not to the extent the said injury or
damage results from the gross negligence or willful misconduct of Sublandlord
or its employees, agents or contractors. 
Sublandlord shall not be liable for any damages arising from any act or
neglect of any other tenant or subtenant of the Project. Notwithstanding
Sublandlord’s negligence or breach of this Sublease, Sublandlord shall under no
circumstances be liable for injury to Subtenant’s business or for any loss of
income or profit therefrom or for any other consequential damages suffered by
Subtenant.

          13.     No
Liability for Master Landlord Defaults. 
Sublandlord shall not be liable to Subtenant for any defaults by Master
Landlord under the Master Lease, nor shall Subtenant be entitled to terminate
this Sublease or to abate Rent (except as provided in Section 7 above) for any
reason including, without limitation, (a) the failure, curtailment, stoppage,
suspension or interruption of any utility or service furnished to the Subleased
Premises or the 501 Building, whether by Master Landlord or anyone else, or (b)
the failure of Master Landlord to keep, maintain, repair or replace the
Subleased Premises as may be required under the Master Lease; provided,
however, if an express provision of the Master Lease gives Sublandlord the
right to terminate the Master Lease upon the occurrence of any event described
in (a) or (b) and Sublandlord elects not to terminate the Master Lease pursuant
to such provision, Subtenant shall have the right to terminate this Sublease on
the same terms and conditions (and within the same time frame) that Sublandlord
has to terminate the Master Lease pursuant to such provision).

          14.     Self-Help:  If Subtenant fails to perform any
affirmative duty or obligation of Subtenant under this Sublease, within ten
(10) days after written notice to Subtenant, Sublandlord may, at its option (but
without obligation to do so), perform such duty or obligation on Subtenant’s
behalf.  The actual and reasonably
expended costs and expenses of any such performance by Sublandlord shall be due
and payable by Subtenant to Sublandlord within five (5) business days after
Subtenant’s receipt of Sublandlord’s invoice therefor.

          15.     Surrender:  On or
before the Expiration Date or the earlier termination of this Sublease,
Subtenant shall remove all of its trade fixtures, furnishings, equipment and
other personal property and all alterations constructed or installed by
Subtenant in the Subleased Premises which Sublandlord designated for removal at
the time Sublandlord approved the construction or installation of such
alterations in the Subleased Premises, and shall surrender the Subleased
Premises to Sublandlord in (a) good condition, order and repair, reasonable
wear and tear and casualty damage or destruction covered by Paragraph 24 of the
Master Lease excepted, and (b) free of any Hazardous Materials used, stored,
handled, manufactured, transported, released, discharged, introduced, emitted
or disposed of by Subtenant or any Subtenant Party.  Subtenant shall repair any damage to the Subleased Premises, the
501 Building or any other part of the Project resulting from the removal of
Subtenant’s trade fixtures, furnishings, equipment, personal property and
alterations, and, at Sublandlord’s sole election, Subtenant shall restore the
Premises to a condition equivalent in all material respects to the condition
that existed as of the Sublease Commencement Date (which may require Subtenant
to reconstruct improvements that were in existence on the Sublease Commencement
Date but that were subsequently removed by Subtenant); provided, however, that
Subtenant shall not be required to reconstruct or remove any improvements
unless, at the time Sublandlord approved the alteration of the Subleased
Premises, Sublandlord conditioned its approval on such subsequent
reconstruction or removal.  Sublandlord
may require the removal at any time of any or all alterations to the Subleased
Premises made by or on behalf of Subtenant without the prior written consent of
Sublandlord and Master Landlord. If the Subleased Premises are not surrendered
as required by this Section 15, then, in addition to all other rights and
remedies of Sublandlord, Subtenant shall be liable to Sublandlord for the
actual and reasonably expended costs incurred by Sublandlord in returning the
Subleased Premises to the required condition, plus interest thereon until paid
at the prime interest rate plus four percent (4%) or, if lower, at the highest,
non-usurious rate permitted by law.  The
provisions of this Section 15 shall survive the expiration or earlier
termination of this Sublease.

          16.     Brokers.
The parties acknowledge that Tory Corporate Real Estate Advisors, Inc. (doing
business as The Staubach Company) (“Sublandlord’s Agent”) has represented
Sublandlord in this transaction and that Cresa Partners (“Subtenant’s Agent”)
has represented Subtenant in this transaction. 
Sublandlord and Subtenant each represent and warrant to the other that,
except for the aforementioned brokers, neither has hired or engaged a real
estate broker, salesman, agent or finder who is or will be entitled to a
commission, fee or other compensation by reason of the transaction contemplated
under this Sublease.  Sublandlord shall
pay Sublandlord’s Agent a real estate commission pursuant to a separate
contractual agreement and not pursuant to the terms of this Sublease.  Sublandlord shall have no obligation to pay
Subtenant’s Agent any commission or other compensation.  Subtenant and Sublandlord each agree to
indemnify and hold the other harmless from and against any and all claims for
brokerage commissions, finder’s fees or other compensation made against the
indemnified party by any agent, broker, salesman or finder as a consequence of
the indemnifying party’s actions or dealings with such agent, broker, salesman,
or finder.  The provisions of this
Section 16 shall survive the expiration or earlier termination of this
Sublease.

          17.     Notices:  Unless at least five (5) business days’ prior written notice is
given in the manner set forth in this paragraph, the address of each party for
all purposes connected with this Sublease shall be that address set forth below
their signatures at the end of this Sublease. 
All notices, demands or communications in connection with this Sublease
shall be properly addressed and delivered as follows:  (a) personally delivered; or (b) submitted to a nationally
recognized overnight courier service, charges prepaid; or (c) deposited in the
mail (certified, return-receipt requested, and postage prepaid).  Notices shall be deemed delivered upon
receipt (which shall include receipt by the front desk, mail or delivery room or
other package or mail repository located at the address for delivery).  All notices given to Master Landlord under
the Master Lease shall be considered received only when delivered in accordance
with the Master Lease.

          18.     Other
Sublease Terms:

                    (a)     Incorporation
by Reference:  Except as otherwise
provided below in this Section 18(a), the terms and conditions of this Sublease
shall include all of the terms and conditions of the Master Lease, and except
as otherwise expressly provided to the contrary in this Sublease, such terms
and conditions are incorporated into this Sublease as if fully set forth
herein, except that:  (i) each reference
in such incorporated terms and conditions to “Lease” shall be deemed a reference
to this “Sublease”, each reference therein to “monthly base rent” shall be
deemed a reference to the “Base Rent” payable under this Sublease, each
reference therein to “rent” shall be deemed a reference to the “Rent” payable
under this Sublease, and each reference to “term commencement date” or
“commencement date” shall be deemed a reference to the “Sublease Commencement
Date”; (ii) each reference in such incorporated terms and conditions to the
“premises” or “Premises” shall be deemed a reference to the “Subleased
Premises”, each reference to the “term” of the Master Lease shall be deemed a
reference to the “Term” of this Sublease, and each reference to the “building”
shall be deemed a reference to the 501 Building (except where such reference is
intended to refer to a building in the Project other than the 501 Building);
(iii) each reference in such incorporated terms and conditions to “Lessor” and
“Lessee” shall be deemed a reference to “Sublandlord” and “Subtenant”,
respectively; (iv) with respect to damage caused by Master Landlord and work,
services, utilities, electricity, repairs, restoration, insurance, indemnities,
reimbursements, representations or warranties provided or to be provided by
Master Landlord, or the performance of any other obligation of Master Landlord
under the Master Lease, Sublandlord shall not be required to perform such
obligation(s) of Master Landlord, but Sublandlord shall perform Sublandlord’s
Master Lease Enforcement Obligations; (v) with respect to any obligation of
Subtenant to be performed under this Sublease, wherever the Master Lease
expressly grants to Sublandlord (as “Lessee”) a specified number of days to
perform its obligations under the Master Lease, except as otherwise provided
herein, Subtenant shall have five (5) fewer days to perform the obligation including,
without limitation, curing any defaults; (vi) with respect to any approval
required to be obtained from the Master Landlord (as “Lessor”) in connection
with the Master Lease, such approval must be obtained from both Master Landlord
and Sublandlord, and Sublandlord’s withholding of approval shall in all events
be deemed reasonable if after making commercially reasonable efforts (which
shall not include the payment of money, the incurring of any liabilities, or
the institution of legal proceedings) to obtain Master Landlord’s approval,
Sublandlord is unable to obtain Master Landlord’s approval; (vii) in any case
under the Master Lease where the Master Landlord (as “Lessor”) reserves or is
granted the right to manage, supervise, control, repair, alter, regulate the
use of, enter, access or use the Subleased Premises or any areas beneath, above
or adjacent thereto, such reservation or grant shall be deemed to be for the
benefit of both Master Landlord and Sublandlord; (viii) in any case under the
Master Lease where Sublandlord (as “Lessee”) indemnifies, releases or waives
claims against Master Landlord (as “Lessor”) or agrees that Master Landlord
shall not be liable, such indemnity, release, waiver or agreement (but only
with respect to the Subleased Premises and Subtenant’s use thereof) shall be
deemed to run from Subtenant in favor of both Master Landlord and Sublandlord;
(ix) in any case under the Master Lease where Sublandlord (as “Lessee”) is to
execute and deliver certain documents or notices to Master Landlord (as
“Lessor”), such obligation shall be deemed to run from Subtenant to both Master
Landlord and Sublandlord;  and (x) the
following modifications shall be made to the Master Lease as incorporated herein:

                              (1)     The following
provisions of the Master
Lease are expressly not incorporated herein: 
Paragraphs 1, 2, 3, 4, 5, 6 and 7 of the Original Lease; the second
sentence of Paragraph 8 of the Original Lease; the last grammatical paragraph
of Paragraph 15 of the Original Lease; Paragraph 16 of the Original Lease; the
last sentence of Paragraph 17 of the Original Lease; Paragraph 18 of the
Original Lease; Paragraph 24 of the Original Lease, excluding the first and
second grammatical paragraphs thereof; Paragraph 26(g) of the Original Lease;
Paragraph 28 of the Original Lease; Paragraph 30 of the Original Lease;
Paragraph 32 of the Original Lease; the words “subject to subparagraph (b)
below,” appearing in Paragraph 33(a) of the Original Lease; the words “and any
Options”, “and such Options”, “or such Options”, “or any Options” appearing in
Paragraph 33(a) of the Original Lease; Paragraph 33(b) of the Original Lease;
Paragraph 34(b) of the Original Lease; Paragraphs 35, 36 and 37 of the Original
Lease; Paragraphs 38, 39, 40 and 41 of the Original Lease; Paragraphs 42(x),
(xvi) and (xviii) of the Original Lease; and Exhibits A1, B, and C to the
Original Lease; the First Amendment in its entirety; Paragraphs 1 and 2, the
first two (2) grammatical paragraphs of Paragraph 3, and Paragraphs 4, 5, 6, 7,
9, 10 and 11 of the Second Amendment; and the entirety of the Third Amendment.

                              (2)     References
to “Lessor” in the following provisions of the Master Lease shall not be deemed
a reference to Sublandlord but shall mean Master Landlord only: Paragraph 12(b)
of the Original Lease; the first and second grammatical paragraphs of Paragraph
24 of the Original Lease; excluding the eighth sentence of such first
grammatical paragraph; Paragraph 25 of the Original Lease; the fourth sentence
of the second grammatical paragraph of Paragraph 9 of the Original Lease; and
Section 1.4.2 of Rider No. 1 to the Original Lease. Without limiting
Sublandlord’s Master Lease Enforcement Obligations, Sublandlord provides no
assurance that Master Landlord will perform any of the above provisions.

                              (3)     References
to “Lease” in the following provisions of the Master Lease shall not be deemed
a reference to this Sublease but shall mean the Master Lease only: the first
and second grammatical paragraphs of Paragraph 24 of the Original Lease;
Paragraph 25 of the Original Lease; the fourth sentence of the second
grammatical paragraph of Paragraph 9 of the Original Lease; Section 1.4.2 of
Rider No. 1 to the Original Lease; and Section 8 of the Second Amendment.

                              (4)     References
to “Lessee” in the following provisions of the Master Lease shall not be deemed
a reference to Subtenant but shall mean Sublandlord only: the first grammatical
paragraph of Paragraph 24 of the Original Lease, excluding the eighth and
twelfth sentences of such first grammatical paragraph; Paragraph 25 of the
Original Lease.

                              (5)     Any
right to abate Rent provided to Subtenant through incorporation of the
provisions of the Master Lease shall not exceed the rent actually abated under
the Master Lease with respect to the Subleased Premises.

                              (6)     References to
“Lessor” in
the following provisions of the Master Lease incorporated herein shall be not
be deemed a reference to Sublandlord only but shall be deemed references to
both Master Landlord and Sublandlord: the eighth and eleventh sentences of the
first grammatical paragraph of Paragraph 24 of the Original Lease; the second
appearance of “Lessor” in the twelfth sentence of the first grammatical
paragraph of Paragraph 24 of the Original Lease; the second grammatical paragraph
of Paragraph 24 of the Original Lease; Paragraph 15(a) of the Original Lease;
the first sentence of Paragraph 17; the seventh grammatical paragraph of
Paragraph 15; and Sections 1.6 and 1.7 of Rider No. 1.

                              (7)     The
word “grossly” shall be inserted between the words “the” and “negligent” in the
18th line of the first grammatical paragraph of Paragraph 23 of the Master
Lease as incorporated herein.  The word
“property” shall be inserted between the words “current” and “insurance” in the
second line of the second grammatical paragraph of Paragraph 19 of the Original
Lease.  The words “or Master Landlord”
shall be inserted between the words “Lessor” and “or” in the seventh line of
Paragraph 42(xvii) of the Original Lease. 
The words “or the Original Lease (to the extent . . . of the Original
Lease)” in Paragraph 26(c) of the Original Lease are hereby deleted. The
reference to “Cygnus Research Corporation, a California corporation (“Cygnus”)”
contained in Section 1.2 of Rider No. 1 shall be deleted and replaced with
“Maxygen, Inc. a Delaware corporation (“Maxygen”) and each reference to
“Cygnus” thereafter appearing in Rider No.1 shall be deleted and replaced with
“Maxygen”.  The following new clause
(vii) shall be added to Section 1.10.1(e) of Rider No. 1 immediately after
existing clause (vi): “or (vii) any toxicological agent.”. Each reference to
“Paragraph 9 of the Lease” contained in Rider No. 1 shall be deemed to refer to
Paragraph 9 of the Original Lease as incorporated in this Sublease.  Each reference to “Paragraph 15 of the
Lease” or “Paragraph 23 of the Lease” shall be deemed to refer to Paragraph 15
of the Original Lease or Paragraph 23 of the Original Lease (as applicable) as
incorporated in this Sublease.  Each
reference to “Paragraph 28 of the Lease” contained in Rider No. 1 shall be
deemed a reference to Section 15 of this Sublease.  The reference to “paragraph 7 of the Lease” contained in Rider
No. 1 shall be deemed a reference to Section 4(b) of this Sublease.

                    (b)     Sublease
Subordinate to Master Lease; Performance: 
This Sublease and the rights of Subtenant hereunder are, and at all
times shall be, subject and subordinate to the Master Lease and the rights of
Master Landlord thereunder, and Subtenant shall at no time use or permit the
use of the Subleased Premises so as to cause a breach, default or violation of
the Master Lease.  Subtenant hereby
agrees to perform the “Lessee’s” obligations under the Master Lease, except as
expressly modified or deleted as provided in this Sublease. Subtenant agrees to
be bound by all of the terms and conditions of the Master Lease.  In the event of any conflict between the
provisions of the Master Lease and the provisions of this Sublease, the
provisions of this Sublease shall control. 
Termination of the Master Lease shall terminate this Sublease at Master
Landlord’s discretion, and such termination shall be without any liability
whatsoever to Sublandlord provided that the termination is not the result of
Sublandlord’s material breach of the Master Lease.

          19.     Parking:  During the Term, Subtenant shall have the non-exclusive right to
use with Sublandlord and other tenants and occupants of the 501 Building and
the balance of the Project a pro rata share of undesignated parking spaces in
the common parking areas of the Project available to Sublandlord for its use
under the Master Lease and subject to the provisions concerning parking set
forth in the Master Lease.  Subtenant’s
pro rata share shall be 36 undesignated spaces, which is equal to 3.3 spaces
per 1,000 rentable square feet of the Subleased Premises.  Subtenant agrees that Subtenant, Subtenant’s
employees, agents and representatives shall not use parking spaces in excess of
said pro rata share of undesignated parking spaces available to Subtenant
hereunder.  Subtenant acknowledges that
the parking spaces being made available to Subtenant hereunder are not reserved
and are subject to use, on a first come first serve basis, by Sublandlord and
other tenants and authorized users of the Project.

          20.     Signage:  Subtenant shall have the right, at
Subtenant’s sole cost and expense, to have building standard signage placed at
the entry door to the Subleased Premises and in various other locations in the
Subleased Premises, subject to obtaining in each instance the prior written
consent thereto of Sublandlord and Master Landlord.  Sublandlord agrees not to unreasonably withhold its consent to
any such signage.  Subtenant shall not
otherwise place any signs on any part of the Subleased Premises, the 501
Building or Project.

          21.     Condition
Precedent:  Notwithstanding anything
to the contrary in this Sublease, this Sublease and the parties’ obligations
hereunder are conditioned upon Sublandlord’s receipt of the written consent of
Master Landlord to this Sublease in form and substance satisfactory to both
Sublandlord and Subtenant.  If
Sublandlord does not receive and provide Subtenant with a copy of the Master
Landlord’s consent as described above within forty (40) days after execution of
this Sublease by Sublandlord, then either Sublandlord or Subtenant may
terminate this Sublease by giving the other written notice thereof, and upon
such termination neither party shall have any further liability or obligation
to the other under or by reason of this Sublease except that Sublandlord shall
return the Security Deposit to Subtenant.

          22.     Amendment:  This Sublease may not be amended or
otherwise modified except by the written agreement of Subtenant and
Sublandlord.

          23.     Counterparts:  This Sublease may be executed in one (1) or
more counterparts, each of which shall be deemed an original, but all of which
together shall constitute one (1) and the same instrument.  Signature copies may be detached from the
counterparts and attached to a single copy of this Sublease physically to form
one (1) document.

          24.     No
Drafting Presumption:  The parties
acknowledge that this Sublease has been agreed to by both the parties, that
both Sublandlord and Subtenant have consulted with their independent attorneys
with respect to the terms of this Sublease, and that no presumption shall be
created against Sublandlord because Sublandlord caused this Sublease to be
drafted.

          25.     Successors
and Assigns: Subject to the limitations described in Section 8 of this
Sublease, this Sublease shall inure to the benefit of, and shall be binding
upon, the parties’ respective heirs, estates, successors and assigns.

          IN
WITNESS WHEREOF, Sublandlord and Subtenant have executed this Sublease as of
the day and year first above written.

	SUBLANDLORD:	SUBTENANT:
	 	 
	CYGNUS, INC., a Delaware corporation	MAXYGEN, INC., a Delaware corporation
	By:	/s/ Neil R. Ackerman

	By:	/s/ Howard Simon

	Print:	Neil R. Ackerman

	Print:	Howard Simon

	Title:	Sr. VP R&D and Sci Affairs

	Title:	VP HR & Administration

	Address: 400 Penobscot Drive

	Address: 515 Galveston Drive
	Redwood City, California 94063

	Redwood City, California 94063
	Attn: President and CEO

	Attn: General Counsel
	Date:	March 30, 2001

	Date:	March 30, 2001Prepared by MerrillDirect

March
23, 2001

VIA FACSIMILE AND REGISTERED MAIL

Robert
L. Chender

Cripple Creek Securities, LLC

195 Maplewood Avenue

Maplewood, New Jersey 07040

RE:     Termination of Equity Line of Credit

Dear
Mr. Chender:

This letter agreement is furnished to you in
connection with the Structured Equity Line Flexible Financing Agreement dated
June 30, 1999, as amended on September 29, 1999, March 27, 2000, May 9, 2000
and October 27, 2000 (as amended, the “Agreement”), between Cripple Creek
Securities, LLC (the “Investor”) and Cygnus, Inc. (the “Company”).  Capitalized terms used herein and not
otherwise defined shall have the meaning ascribed thereto in the Agreement.

By execution of this letter agreement, the
Investor and the Company hereby agree that for good and
valuable consideration, the receipt and sufficiency of which is hereby
acknowledged, the respective parties hereto waive any notice requirements under
the Agreement and agree that the Agreement shall be terminated effective upon
the date hereof; provided, however, that any provisions of the
Agreement with respect to the rights and obligations of the parties following
termination of the Agreement shall survive such termination.  Except
as otherwise expressly provided herein, as of the date hereof, each of
the respective parties hereto hereby releases the other party hereto from all
obligations arising out of the Agreement, and none of the parties shall have
any further rights arising out of the Agreement.  The parties hereto agree that there are no further obligations
due and owing under the Agreement with the exception that the warrants issued for calendar year 1999 or to be
issued for calendar years 2000 and 2001 in connection with the Agreement shall
remain outstanding and unaffected by this letter agreement .  The
parties also agree that the June 30, 1999 Registration Rights Agreement is
unaffected by this letter agreement.

This letter agreement supersedes any prior
discussions, offers or agreements, whether written or oral, concerning the
subject matter of this letter.

Please
acknowledge your receipt of this letter and your agreement with the matters
herein contained by signing below. 
Kindly return one fully executed original.  The duplicate original is for your files.

	 	 	CYGNUS, INC.
	 	 	 
	 	By:	/s/ Craig W. Carlson

	 	 	Craig W. Carlson
	 	 	Senior Vice President - Finance and Chief Financial Officer

AGREED
AND ACCEPTED:

CRIPPLE
CREEK SECURITIES, LLC

	By:	/s/ Robert L. Chender

	 	    
  Robert L. Chender
	 	    
  Principal
	 	 
	cc:	Arnold &
  Porter
	 	555 Twelfth
  Street, NW

  Washington, D.C. 20004
Attention: L. Stevenson Parker
Facsimile: (202) 942-5999

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