Document:

2004 STOCK OPTION PLAN

 Exhibit 10.14 
 LEMAITRE VASCULAR, INC. 
 2004 STOCK OPTION PLAN 
 1. Purpose. This 2004 Stock Option Plan (the “Plan”) is intended to provide incentives: (a) to employees, and officers and
directors who are also employees, of LeMaitre Vascular, Inc., a Delaware corporation (the “Company”), and any present or future parent or subsidiaries of the Company (collectively, “Related Corporations”) by providing them with
opportunities to purchase stock in the Company pursuant to options granted hereunder which qualify as “incentive stock options” under Section 422(b) of the Internal Revenue Code of 1986 (the “Code”) (“ISO” or
“ISOs”); and (b) to directors, officers, employees and consultants of the Company and Related Corporations by providing them with opportunities to purchase stock in the Company pursuant to options granted hereunder which do not
qualify as ISOs (“Non-Qualified Option” or “Non-Qualified Options”). Both ISOs and Non-Qualified Options are referred to hereafter individually as an “Option” and collectively as “Options”. As used herein, the
terms “parent” and “subsidiary” mean “parent corporation” and “subsidiary corporation”, respectively, as those terms are defined in Section 424 of the Code. 
 2. Administration of the Plan. 
 A.
Board or Committee Administration. The Plan shall be administered by the Board of Directors of the Company (the “Board”). The Board may appoint a Compensation Committee or a Stock Option Plan Committee (as the case may be, the
“Committee”) of three (3) or more of its members to administer the Plan and to grant Options hereunder, provided such Committee is delegated such powers in accordance with state law. (All references in this Plan to the
“Committee” shall mean the Board if no such Compensation Committee or Stock Option Plan Committee has been so appointed). In the event the Company registers any class of any equity security pursuant to Section 12 of the Securities
Exchange Act of 1934, as amended (the “Exchange Act”), the Plan shall be administered in accordance with the applicable rules set forth in Rule 16b-3 or any successor provisions of the Exchange Act (“Rule 16b-3”). 
 B. Authority of Board or Committee. Subject to the terms of the Plan, the Committee shall have the authority to: 
 (i) determine the employees of the Company and Related Corporations (from among the class of employees eligible under paragraph 3 to receive ISOs) to whom
ISOs may be granted, and to determine (from among the class of individuals and entities eligible under paragraph 3 to receive Non-Qualified Options) to whom Non-Qualified Options may be granted; (ii) determine the time or times at which options
may be granted; (iii) determine the option price of shares subject to each Option, which price shall not be less than the minimum price specified in paragraph 6; 
  

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 (iv) determine whether each Option granted shall be an ISO or a Non-Qualified Option; (v) determine
(subject to paragraph 7) the duration of the exercise period for each Option and the time or times when each Option shall become exercisable provided, however, that unless otherwise determined by the Committee ISOs will become exercisable in
accordance with paragraph 8A; (vi) determine whether restrictions, such as repurchase rights, are to be imposed on shares subject to Options and the nature of such restrictions, if any, (vii) impose such other terms and conditions with
respect to Options and shares subject to Options not inconsistent with the terms of this Plan as it deems necessary or advisable, and (viii) interpret the Plan and prescribe and rescind rules and regulations relating to it. If the Committee
determines to issue a Non-Qualified Option, it shall take whatever actions it deems necessary, under the Code and the regulations promulgated thereunder, to ensure that such Option is not treated as an ISO. The interpretation and construction by the
Committee of any provisions of the Plan granted under it shall be final unless otherwise determined by the Board. The Committee may from time to time adopt such rules and regulations for carrying out the Plan as it may deem best. No member of the
Board or the Committee shall be liable for any action, determination or omission made in good faith with respect to the Plan or any options granted under it. 
 C. Committee Actions. The Committee may select one of its members as its chairman, and shall hold meetings at such time and places as it may determine. Acts by a majority of the Committee, or acts reduced to or
approved in writing by a majority of the members of the Committee, shall be the valid acts of the Committee. From time to time the Board may increase the size of the Committee and appoint additional members thereof, remove members (with or without
cause) and appoint new members in substitution therefor, fill vacancies however caused, or remove all members of the Committee and thereafter directly administer the Plan. 
 D. Grant of Stock Rights to Board Members. Options may be granted to members of the Board, subject to compliance with Rule 16b-3 when required by
the last sentence of paragraph 2A. All grants of Options to members of the Board shall in all respects be made in accordance with the provisions of this Plan applicable to other eligible persons. 
 3. Eligible Employees and Others. ISOs may be granted to any employee of the Company or any Related Corporation. Those officers and directors of
the Company who are not employees may not be granted ISOs under the Plan. Non-Qualified Options may be granted to any employee, officer or director (whether or not also an employee) or consultant of the Company or any Related Corporation. The
Committee may take into consideration a recipient’s individual circumstances in determining whether to grant an ISO or a Non-Qualified Option. Granting of any Option to any individual or entity shall neither entitle that individual or entity
to, nor disqualify him from, participation in any other grant of Options. 
  

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 4. Stock. The stock subject to Options shall be authorized but unissued shares of Common Stock of
the Company, no par value (the “Common Stock”), or shares of Common Stock reacquired by the Company in any manner. The aggregate number of shares which may be issued pursuant to the Plan is 250,000, subject to adjustment as provided in
paragraph 13. Any such shares may be issued as ISOs or Non-Qualified Options so long as the aggregate number of shares so issued does not exceed such number, as adjusted. If any Option granted under the Plan shall expire or terminate for any reason
without having been exercised in full or shall cease for any reason to be exercisable in whole or in part, the unpurchased shares subject to such Options shall again be available for grants of Options under the Plan. 
 5. Granting of Options. Options may be granted under the Plan at any time after April 20, 2004 and prior to April 19, 2014. The date of
grant of an Option under the Plan will be the date specified by the Committee at the time it grants the Option; provided, however, that such date shall not be prior to the date on which the Committee acts to approve the grant. The Committee shall
have the right, with the consent of the optionee, to convert an ISO granted under the Plan to a Non-Qualified Option pursuant to paragraph 16. 
 6. Minimum Option Price; ISO Limitations. 
 A. Price for Non-Qualified Options. The exercise price per share specified
in the agreement relating to each Non-Qualified Option granted under the Plan shall in no event be less than the book value per share of Common Stock as of the end of the fiscal year of the Company immediately preceding the date of such grant.

 B. Price for ISOs. The exercise price per share specified in the agreement relating to each ISO granted under the Plan shall in no
event be less than the fair market value per share of Common Stock on the date of such grant. In the case of an ISO to be granted to an employee owning stock possessing more than ten percent (10%) of the total combined voting power of all
classes of stock of the Company or any Related Corporation, the price per share specified in the agreement relating to such ISO shall not be less than one hundred ten percent (110%) of the fair market value per share of Common Stock on the date
of grant. 
 C. $100,000 Annual Limitation on ISOs. Each eligible employee may be granted ISOs only to the extent that, in the
aggregate under this Plan and all incentive stock option plans of the Company and any Related Corporation, such ISOs do not become exercisable for the first time by such employee during any calendar year in a manner which would entitle the employee
to purchase more than $100,000 in fair market value (determined at the time the ISOs were granted) of Common Stock in that year. Any options granted to an employee in excess of such amount will be granted as Non-Qualified Options. 
  

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 D. Determination of Fair Market Value. If, at the time an option is granted under the Plan, the
Company’s Common Stock is publicly traded, “fair market value” shall be determined as of the last business day for which the prices or quotes discussed in this sentence are available prior to the date such Option is granted and shall
mean (i) the average (on that date) of the high and low prices of the Common Stock on the principal national securities exchange on which the Common Stock is traded, if the Common Stock is then traded on a national securities exchange; or
(ii) the last reported sale price (on that date) of the Common Stock on the NASDAQ National Market List, if the Common Stock is not then traded on a national securities exchange; or (iii) the closing bid price (or average of bid prices)
last quoted (on that date) by an established quotation service for over-the-counter securities, if the Common Stock is not reported on the NASDAQ National Market List. However, if the Common Stock is not publicly traded at the time an Option is
granted under the Plan, “fair market value” shall be deemed to be the fair value of the Common Stock as determined by the Committee after taking into consideration all factors in good faith it deems appropriate, including, without
limitation, recent sale and offer prices of the Common Stock in private transactions negotiated at arm’s length. 
 7. Option
Duration. Subject to earlier termination as provided in paragraphs 9 and 10, each Option shall expire on the date specified by the Committee and set forth in the original instrument granting such Option, but not more than ten years from the date
of grant. Notwithstanding the foregoing, in the case of ISOs granted to an employee owning stock possessing more than ten percent (10%) of the total combined voting power of all classes of stock of the Company or any Related Corporation, such
ISOs shall expire not more than five years from the date of grant. Non-Qualified Options shall expire on the date specified in the instrument granting such Non-Qualified Options, subject to extension as determined by the Committee. ISOs, or any part
thereof, that have been converted into Non-Qualified Options may be extended as provided in paragraph 16. 
 8. Exercise of Option.
Subject to the provisions of paragraphs 9 through 12, each Option granted under the Plan shall be exercisable as follows: 
 A. Vesting. Unless otherwise specified by the Committee and subject to paragraphs 9 and 10 with respect to ISOs, Options granted to employees shall vest in accordance with the following schedule: in 5 equal annual installments
beginning one calendar year after the date of such anniversary. The Committee in the alternative may provide for any Option to be fully exercisable on the date of grant or exercisable thereafter in such installments as may be specified in the
original instrument granting such Option. The Committee may also specify such other conditions precedent as it deems appropriate to the exercise of an Option. 
  

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 B. Full Vesting of Installments. Once an installment becomes exercisable it shall
remain exercisable until expiration or termination of the Option, unless otherwise specified by the Committee. 
 C.
Partial Exercise. Each Option or installment may be exercised at any time or from time to time, in whole or in part, for up to the total number of shares with respect to which it is then exercisable, provided that the Committee may specify a
certain minimum number or percentage of the shares issuable upon exercise of any Option that must be purchased upon any exercise. 
 D. Acceleration of Vesting. The Committee shall have the right to accelerate the date of exercise of any installment of any Option; provided that the Committee shall not accelerate the exercise date of any installment of any Option
granted to any employee as an ISO (and not previously converted into a Non-Qualified Option pursuant to paragraph 16) if such acceleration would violate the annual vesting limitation contained in Section 422(d) of the Code, as described in
paragraph 6(C). 
 9. Termination of Employment. If an ISO optionee ceases to be employed by the Company and all Related Corporations
other than by reason of death or disability as defined in paragraph 10, no further installments of his ISOs shall become exercisable following the date of such cessation of employment, and his ISOs shall terminate after the passage of ninety
(90) days from the date of termination of his employment, but in no event later than on their specified expiration dates, except to the extent that such ISOs (or unexercised installments thereof) have been converted into Non-Qualified Options
pursuant to paragraph 16. Nothing in the Plan shall be deemed to give any grantee of any Option the right to be retained in employment or other service by the Company or any Related Corporation for any period of time. 
 10. Death; Disability. 
 A. Death. If an ISO optionee ceases to be employed by the Company and all Related Corporations by reason of his death, or if the employee dies within the thirty (30) day period after the employee ceases to be employed by the
Company and all Related Corporations, any ISO of his may be exercised, to the extent of the number of shares with respect to which he could have exercised it on the date of his death, by his estate, personal representative or beneficiary who has
acquired the ISO by will or by the laws of descent and distribution, at any time prior to the earlier of the specified expiration date of the ISO or one hundred and eighty (180) days from the date of the optionee’s death. 
 B Disability. If an ISO optionee ceases to be employed by the Company and all Related Corporations by reason of his disability, he
shall have the right to exercise any ISO held by him on the date of termination of employment, to the extent of the number of shares with respect to which he could 
  

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 have exercised it on that date, at any time prior to the earlier of the specified expiration date of the
ISO or one (1) year from the date of the termination of the optionee’s employment. For the purposes of the Plan, the term “disability” shall mean “permanent and total disability” as defined in Section 22(e)(3) of
the Code or successor statute. 
 11. Assignability. No Option shall be assignable or transferable by the optionee except by will or
by the laws of descent and distribution, and during the lifetime of the optionee each Option shall be exercisable only by him. No Option, nor the right to exercise any portion thereof, shall be subject to execution, attachment, or similar process,
assignment, or any other alienation or hypothecation. Upon any attempt so to transfer, assign, pledge, hypothecate, or otherwise dispose of any Option, or of any right or privilege conferred thereby, contrary to the provisions thereof or hereof or
upon the levy of any attachment or similar process upon any Option, right or privilege, such Option and such rights and privileges shall immediately become null and void. 
 12. Terms and Conditions of Options. Options shall be evidenced by instruments (which need not be identical) in such forms as the Committee may from time to time approve. Such instruments shall conform to the
terms and conditions set forth in paragraphs 6 through 11 hereof and may contain such other provisions as the Committee deems advisable which are not inconsistent with the Plan. Without limiting the foregoing, such provisions may include transfer
restrictions, rights of refusal, repurchase and drag along rights with respect to shares of Common Stock issuable upon exercise of Options, and such other restrictions applicable to shares of Common Stock issuable upon exercise of Options as the
Committee may deem appropriate. In granting any Non-Qualified Option, the Committee may specify that such Non-Qualified Option shall be subject to the restrictions set forth herein with respect to ISOs, or to such other termination, cancellation or
other provisions as the Committee may determine. The Committee may from time to time confer authority and responsibility on one or more of its own members and/or one or more officers of the Company to execute and deliver such instruments. The proper
officers of the Company are authorized and directed to take any and all action necessary or advisable from time to time to carry out the terms of such instruments. 
 13. Adjustments. Upon the occurrence of any of the following events, an optionee’s rights with respect to Options granted to him hereunder shall be adjusted as hereinafter provided, unless otherwise
specifically provided in the written agreement between the optionee and the Company relating to such Option: 
 A. Stock Dividends and
Stock Splits. If the shares of Common Stock shall be subdivided or combined into a greater or smaller number of shares or if the Company shall issue any shares of Common Stock as a stock dividend on its outstanding Common Stock, the number of
shares of Common Stock deliverable upon the exercise of Options shall be appropriately increased or decreased proportionately, and appropriate adjustments shall be made in the purchase price per share to reflect such subdivision, combination or
stock dividend. 
  

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 B. Consolidations, Mergers or Sales of Assets or Stock. If the Company is to be consolidated with
or acquired by another person or entity in a merger, sale of all or substantially all of the Company’s assets or stock or otherwise (an “Acquisition”), the Committee or the board of directors of any entity assuming the obligations of
the Company hereunder (the “Successor Board”) shall, with respect to outstanding Options or shares acquired upon exercise of any Option, take one or more of the following actions: (i) make appropriate provision for the continuation of
such Options by substituting on an equitable basis for the shares then subject to such Options the consideration payable with respect to the outstanding shares of Common Stock in connection with the Acquisition; (ii) accelerate the date of
exercise of such Options or of any installment of any such Options; (iii) upon written notice to the optionees, provide that all Options must be exercised, to the extent then exercisable, within a specified number of days of the date of such
notice, at the end of which period the Options shall terminate; (iv) terminate all Options in exchange for a cash payment equal to the excess of the fair market value of the shares subject to such Options (to the extent then exercisable) over
the exercise price thereof; or (v) in the event of a stock sale, require that the optionee sell to the purchaser to whom such stock sale is to be made, all shares previously issued to such optionee upon exercise of any Option, at a price equal
to the portion of the net consideration from such sale which is attributable to such shares. 
 C. Recapitalization or Reorganization.
In the event of a recapitalization or reorganization of the Company (other than a transaction described in subparagraph B above) pursuant to which securities of the Company or of another corporation are issued with respect to the outstanding shares
of Common Stock, an optionee upon exercising an Option shall be entitled to receive for the purchase price paid upon such exercise the securities he would have received if he had exercised his Option prior to such recapitalization or reorganization
and had been the owner of the Common Stock receivable upon such exercise at such time. 
 D. Modification of ISOs. Notwithstanding the
foregoing, any adjustments made pursuant to the foregoing subparagraphs A, B or C with respect to ISOs shall be made only after the Committee, after consulting with counsel for the Company, determines whether such adjustments would constitute a
“modification” of such ISOs (as that term is defined in Section 424 of the Code or any successor thereto) or would cause any adverse tax consequences for the holders of such ISOs. If the Committee determines that such adjustments made
with respect to ISOs would constitute a modification of such ISOs or would cause any such adverse tax consequences, it may refrain from making such adjustments. 
 E. Dissolution or Liquidation. In the event of the proposed dissolution or liquidation of the Company, each Option will terminate immediately prior to the consummation of such proposed action or at such other
time and subject to such other conditions as shall be determined by the Committee. 
  

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 F. Issuances of Securities. Except as expressly provided herein, no issuance by the Company of
shares of stock of any class, or securities convertible into shares of stock of any class, shall affect, and no adjustment by reason thereof shall be made with respect to, the number or price of shares subject to Options. No adjustments shall be
made for dividends paid in cash or in property other than securities of the Company (and, in the case of securities of the Company, such adjustments shall be made pursuant to the foregoing subparagraph A). 
 G. Fractional Shares. No fractional shares shall be issued under the Plan and the optionee shall receive from the Company cash in lieu of such
fractional shares. 
 H. Adjustments. Upon the happening of any of the foregoing events described in subparagraphs A, B or C above,
the class and aggregate number of shares set forth in paragraph 4 hereof that are subject to Options which previously have been or subsequently may be granted under the Plan shall also be appropriately adjusted to reflect the events described in
such subparagraphs. The Committee or the Successor Board shall determine the specific adjustments to be made under this paragraph 13 and its determination shall be conclusive. 
 If any person or entity owning Common Stock obtained by exercise of an Option made hereunder receives shares or securities or cash in connection with a corporate transaction described in subparagraphs A, B or C above
as a result of owning such Common Stock, such shares or securities or cash shall be subject to all of the conditions and restrictions applicable to the Common Stock with respect to which such shares or securities or cash were issued, unless
otherwise determined by the Committee. 
 14. Means of Exercising Options. An Option (or any part or installment thereof) shall be
exercised by giving written notice to the Company at its principal office address. Such notice shall identify the Option being exercised and specify the number of shares as to which such Option is being exercised, accompanied by full payment of the
purchase price therefor either (a) in United States dollars in cash or by check, or (b) at the discretion of the Committee, through delivery of shares of Common Stock having a fair market value equal as of the date of the exercise to the
cash exercise price of the Option, or (c) at the discretion of the Committee, by delivery of the grantee’s personal recourse note bearing interest payable not less than annually at no less than 100% of the lowest applicable Federal rate,
as defined in Section 1274(d) of the Code, and on such other terms as may be specified by the Committee, or (d) at the discretion of the Committee, by any combination of (a), (b) and (c) above, and subject to such additional
conditions as the Committee may impose. If the Committee exercises its discretion to permit payment of the exercise price of an ISO by means of the methods set forth in clauses (b), (c), or (d) of the preceding sentence, such discretion shall
be exercised in writing at the time of the grant of the ISO in question or in the instrument evidencing such grant. The holder of an 
  

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 Option shall not have the rights of a shareholder with respect to the shares covered by his Option until the date of
issuance of a stock certificate to him for such shares. Except as expressly provided above in paragraph 13 with respect to changes in capitalization and stock dividends, no adjustment shall be made for dividends or similar rights for which the
record date is before the date such stock certificate is issued. The Committee may impose such conditions to the issuance and delivery of stock certificates as it deems necessary or appropriate. 
 15. Term and Amendment of Plan. This Plan was adopted by the Board on April 20, 2004 and will be presented to the stockholders of the Company
for approval on or prior to April 19, 2005. If the approval of stockholders is not obtained by such one year anniversary, any grants of ISOs under the Plan made prior to that date will be rescinded. The Plan shall expire on April 19, 2014
(except as to Options outstanding on that date). Subject to the provisions of paragraph 5 above, Options may be granted under the Plan prior to the date of stockholder approval of the Plan. 
 The Board may terminate or amend the Plan in any respect at any time, except that, without the approval of the stockholders obtained within 12 months
before or after the Board adopts a resolution authorizing any of the following actions: (a) the total number of shares that may be issued under the Plan may not be increased (except by adjustment pursuant to paragraph 13); (b) the
provisions of paragraph 3 regarding eligibility for grants of ISOs may not be modified; (c) the provisions of paragraph 6(B) regarding the exercise price at which shares may be offered pursuant to ISOs may not be modified (except by adjustment
pursuant to paragraph 13); and (d) the expiration date of the Plan may not be extended. Except as otherwise provided in this paragraph 15, in no event may action of the Board, the Committee or stockholders alter or impair the rights of a
grantee under any Option previously granted to him, without his consent. 
 16. Conversion of ISOs into Non-Qualified Options; Termination
of ISOs. The Committee, at the written request of any optionee, may in its discretion take such actions as may be necessary to convert such optionee’s ISOs (or any installments or portions of installments thereof) that have not been
exercised on the date of conversion into Non-Qualified Options at any time prior to the expiration of such ISOs, regardless of whether the optionee is an employee of the Company or a Related Corporation at the time of such conversion. Such actions
may include, but not be limited to, extending the exercise period or reducing the exercise price of the appropriate installments of such Options. At the time of such conversion, the Committee may impose such conditions on the exercise of the
resulting Non-Qualified Options as the Committee in its discretion may determine, provided that such conditions shall not be inconsistent with this Plan. Nothing in the Plan shall be deemed to give any optionee the right to have such optionee’s
ISOs converted into Non-Qualified Options, and no such conversion shall occur until and unless the Committee takes appropriate action. The Committee, with the consent of the optionee, may also terminate any portion of any ISO that has not been
exercised at the time of such conversion. 
  

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 17. Application Of Funds. The proceeds received by the Company from the sale of shares pursuant to
Options granted under the Plan shall be used for general corporate purposes. 
 18. Governmental Regulation. The Company’s
obligation to sell and deliver shares of the Common Stock under this Plan is subject to the approval of any governmental authority required in connection with the authorization, issuance or sale of such shares. 
 19. Withholding of Additional Income Taxes. Upon the exercise of a Non-Qualified Option, or for the making of a Disqualifying Disposition (as
described in paragraph 20), the Company, in accordance with Section 3402(a) of the Code, may require the optionee to pay additional withholding taxes in respect of the amount that is considered compensation includible in such person’s
gross income. The Committee in its discretion may condition the exercise of an Option on the grantee’s payment of such additional withholding taxes. 
 20. Notice to Company of Disqualifying Disposition. Each employee who receives an ISO must agree to notify the Company in writing immediately after the employee makes a Disqualifying Disposition of any Common
Stock acquired pursuant to the exercise of an ISO. A Disqualifying Disposition is any disposition (including any sale) of such Common Stock before the later of 
 (a) two years after the date the employee was granted the ISO, or 
 (b) one year after the date the employee
acquired Common Stock by exercising the ISO. If the employee has died before such stock is sold, these holding period requirements do not apply and no Disqualifying Disposition can occur thereafter. 
 21. Governing Law; Construction. The validity and construction of the Plan and the instruments evidencing Options shall be governed by the laws of
the Commonwealth of Massachusetts, or the laws of any jurisdiction in which the Company or its successors in interest may be organized. In construing this Plan, the singular shall include the plural and the masculine gender shall include the
feminine and neuter, unless the context otherwise requires. 
  

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 FORM OF 2004 STOCK OPTION PLAN INCENTIVE STOCK OPTION AGREEMENT 
 Employee’s Last Name:
                         
 LEMAITRE VASCULAR, INC. 
 Incentive Stock Option Agreement 
 LeMaitre Vascular, Inc., a Delaware corporation (the “Company”), hereby grants this
             day of                      to
                     (the “Employee”), in consideration of the Employee’s continued employment with the Company and the
execution of the Company’s Employee Obligations Agreement, an option to purchase a maximum of              shares (individually, a “Share”, and collectively,
the “Shares”) of its Common Stock, $.01 par value (the “Common Stock”), at the price of              per Share on the following terms and conditions: 

1. Grant Under 2004 Stock Option Plan. This option is granted pursuant to and is governed by the Company’s 2004 Stock Option Plan (the
“Plan”) and, unless the context otherwise requires, terms used herein shall have the same meaning as in the Plan. Determinations made in connection with this option pursuant to the Plan shall be governed by the Plan as it exists on this
date. The Plan was approved by the Company’s stockholders on May 6, 2004. 
 2. Grant as Incentive Stock Option; Other
Options. This option is intended to qualify as an incentive stock option under Section 422(b) of the Internal Revenue Code of 1986. This option is in addition to any other options heretofore or hereafter granted to the Employee by the
Company, but a duplicate original of this instrument shall not affect the grant of another option. 
 3. Extent of Option if Employment
Continues. If the Employee has continued to be employed by the Company on the applicable dates, the Employee may exercise this option for the following number of Shares:
            . The foregoing rights are cumulative and, while the Employee continues to be employed by the Company, may be exercised on or before
                    . All of the foregoing rights are subject to Articles 4 and 5, as appropriate, if the Employee ceases to be
employed by the Company or dies or becomes disabled while in the employ of the Company. 
  

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 4. Termination of Employment. If the Employee ceases to be employed by the Company, other than by
reason of death or disability as defined in Article 5, no further installments of this option shall become exercisable following the date of such cessation of employment and this option shall terminate after the passage of ninety (90) days from
the date employment ceases, but in no event later than the scheduled expiration date. In such a case, the Employee’s only rights hereunder shall be those which are properly exercised before the termination of this option. 
 5. Death; Disability. If the Employee dies while in the employ of the Company, this option may be exercised, to the extent of the number of shares
with respect to which the Employee could have exercised it on the date of his death, by his estate, personal representative or beneficiary to whom this option has been assigned pursuant to Article 10, at any time within 180 days after the date of
death, but not later than the scheduled expiration date. If the Employee ceases to be employed by the Company by reason of his disability (as defined in the Plan), this option may be exercised, to the extent of the number of shares with respect to
which he could have exercised it on the date of the termination of his employment, at any time within one (1) year after such termination, but not later than the scheduled expiration date. At the expiration of either such 180-day or one year
period or the scheduled expiration date, whichever is the earlier, this option shall terminate and the only rights hereunder shall be those as to which the option was properly exercised before such termination. 
 6. Partial Exercise. Exercise of this option up to the extent above stated may be made in part at any time and from time to time within the above
limits, except that this option may not be exercised for a fraction of a share unless such exercise is with respect to the final installment of stock subject to this option and a fractional share (or cash in lieu thereof) must be issued to permit
the Employee to exercise completely such final installment. Any fractional share with respect to which an installment of this option cannot be exercised because of the limitation contained in the preceding sentence shall remain subject to this
option and shall be available for later purchase by the Employee in accordance with the terms hereof. 
 7. Payment of Price. The
option price is payable in United States dollars and may be paid: 
 (a) either (i) in cash, (ii) by check, or (iii) any
combination of the foregoing, equal in amount to the option price. 
  

	
	  

	(Initials)

 (b) either (i) in cash, (ii) by check, (iii) after the Company’s Initial
Public Offering (as defined in Article 20) at a time when the Common Stock is publicly traded, by delivery of shares of the Company’s Common Stock, which have been owned by the 
  

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 Employee for a minimum period of six months, having an aggregate fair market value (as determined in accordance with the
Plan) equal as of the date of exercise to the option price, or (iv) by any combination of the foregoing, equal in amount to the option price. 
  

	
	  

	(Initials)

 8. Agreement to Purchase for Investment. By acceptance of this option, the Employee
agrees that a purchase of Shares under this option will not be made with a view to their distribution, as that term is used in the Securities Act of 1933, as amended, and that he will not sell, transfer, pledge or otherwise dispose of such shares
unless in the opinion of counsel to the Company such sale, transfer, pledge or other disposition is in compliance with or exempt from the registration and prospectus requirements of that Act. Furthermore, the Employee agrees to sign a certificate to
the foregoing effect at the time of exercising this option and agrees that the certificate for the Shares so purchased may be inscribed with a legend to ensure compliance with this Article 8, Article 10 and the Securities Act of 1933. 
 9. Method of Exercising Option. Subject to the terms and conditions of this Agreement, this option may be exercised by written notice to the
Company, at the principal executive office of the Company, or to such transfer agent as the Company shall designate. Such notice shall state the election to exercise this option and the number of Shares in respect of which it is being exercised (or
that an election is being made to purchase the maximum number of Shares so purchasable in accordance with the last paragraph of Article 7) and shall be signed by the person or persons so exercising this option. Such notice shall be accompanied by
payment of the full purchase price of such Shares. The Company shall deliver a certificate or certificates representing such Shares as soon as practicable after the notice shall be received. The certificate or certificates for the Shares as to which
this option shall have been so exercised shall be registered in the name of the person or persons so exercising this option (or, if this option shall be exercised by the Employee and if the Employee shall so request in the notice exercising this
option, shall be registered in the name of the Employee and another person jointly, with right of survivorship) and shall be delivered as provided above to or upon the written order of the person or persons exercising this option. In the event this
option shall be exercised, pursuant to Article 5 hereof, by any person or persons other than the Employee, such notice shall be accompanied by appropriate proof of the right of such person or persons to exercise this option. All Shares that shall be
purchased upon the exercise of this option as provided herein shall be fully paid and non-assessable. 
 10. Transfer Restrictions.

 (a) Restriction on Transfer of Shares. The Employee may not sell, assign, transfer or otherwise dispose of any Shares at any time
prior to the effective date of an Initial Public Offering, except: (i) with the prior written consent of and subject to such conditions as may be imposed by the Board; (ii) by will or by the laws of descent and 
  

 -3- 

 distribution; or (iii) pursuant to Article 17 or Article 19. Unless otherwise agreed to in writing by the Company,
any sale, assignment, transfer or disposition hereunder shall continue to be subject to Sections 17 and 19 hereof to the same extent as if the Shares continued to be owned by the Employee. 
 (b) Restriction on Transfer/Exercise of Option. This option is not transferable or assignable except by will or by the laws of descent and
distribution. During the Employee’s lifetime only the Employee can exercise this option. 
 11. No Obligation to Exercise Option.
The grant and acceptance of this option imposes no obligation on the Employee to exercise it. 
 12. No Obligation to Continue
Employment. The Company and any Related Corporation (as defined in the Plan) are not by the Plan or this option obligated to continue the Employee in employment for any period of time. 
 13. No Rights as Stockholder until Exercise. The Employee shall have no rights as a stockholder with respect to Shares subject to this Agreement
until a stock certificate therefor has been issued to the Employee and is fully paid for. Except as is expressly provided in the Plan with respect to certain changes in the capitalization of the Company, no adjustment shall be made for dividends or
similar rights for which the record date is prior to the date such stock certificate is issued. 
 14. Capital Changes and Business
Successions. The Plan contains provisions covering the treatment of options in a number of contingencies such as stock splits, mergers and sales of the Company’s stock or assets. Provisions in the Plan for adjustment with respect to stock
subject to options and the related provisions with respect to successors to the business of the Company are hereby made applicable hereunder and are incorporated herein by reference. In general, you should not assume that options necessarily would
survive the acquisition of the Company. In particular, without affecting the generality of the foregoing, it is understood that for the purposes of Articles 3 through 5 hereof, both inclusive, employment by the Company includes employment by a
Related Corporation as defined in the Plan. 
 15. Early Disposition. Without limiting the generality of Articles 8 and 10, the
Employee agrees to notify the Company in writing immediately after the Employee makes a Disqualifying Disposition (as defined below) of any Common Stock received pursuant to the exercise of this option. A Disqualifying Disposition is any disposition
(including any sale) of such Common Stock before the later of (a) two years after the date the Employee was granted this option or (b) one year after the date the Employee acquired Common Stock by exercising this option. If the Employee
has died before such stock is sold, these holding period requirements do not apply and no Disqualifying Disposition can occur thereafter. The Employee also agrees to provide the Company with any information which it shall request concerning any such
disposition. The Employee acknowledges that he will forfeit the favorable income tax treatment otherwise available with respect to the exercise of this incentive stock option if he makes a Disqualifying Disposition of the stock received on exercise
of this option. 
  

 -4- 

 16. Withholding Taxes. If the Company in its discretion determines that it is obligated to
withhold tax with respect to a Disqualifying Disposition (as defined in Article 15) of Common Stock received by the Employee on exercise of this option, the Employee hereby agrees that the Company may withhold from the Employee’s wages the
appropriate amount of federal, state and local withholding taxes attributable to such Disqualifying Disposition. If any portion of this option is treated as a Non-Qualified Option (as defined in the Plan), the Employee hereby agrees that the Company
may withhold from the Employee’s wages the appropriate amount of federal, state and local withholding taxes attributable to the Employee’s exercise of such Non-Qualified Option. At the Company’s discretion, the amount required to be
withheld may be withheld in cash from such wages, or (with respect only to the minimum amount required to be withheld from the Employee under applicable law due to compensation income attributable to the exercise of this option) in kind from the
Common Stock otherwise deliverable to the Employee (or other person or persons) on exercise of this option. The Employee further agrees that, if the Company does not withhold an amount from the Employee’s wages sufficient to satisfy the
Company’s withholding obligation, the Employee will reimburse the Company on demand, in cash, for the amount underwithheld. 
 17.
Drag Along Right. 
 (a) Exercise of Right: If one or more persons who own in the aggregate more than 50% of the then
outstanding shares of Common Stock of the Company shall obtain a bona fide offer for the purchase of more than 50% of the outstanding Common Stock of the Company from an offeror (the “Offeror”), such person(s) shall have the right to
require, by written notice (the “Drag Along Notice”), any person who holds Shares pursuant to this Agreement (the “Notice Recipient”) to cause all of the Shares acquired under this option to be transferred to the Offeror, on the
same terms and conditions (including without limitation, per share price) applicable to, and at the same time as, the transfer to the Offeror by the person(s) giving the Drag Along Notice. If the sale to the Offeror has not occurred within 180 days
following the date of the Drag Along Notice, the Notice Recipient shall be released from his obligation under the Drag Along Notice, and it shall be necessary for a new and separate Drag Along Notice to be furnished and the terms and provisions of
this Article 17 to be separately complied with in order to consummate such a sale pursuant to this Article 17, unless the failure to complete such sale resulted from any failure by the Notice Recipient. Each Notice Recipient shall take or cause to
be taken all such actions as may be reasonably requested in order to expeditiously consummate a sale pursuant to this Article 17. 
 (b)
Adjustments for Changes in Capital Structure: If there shall be any change in the Common Stock of the Company through merger, consolidation, reorganization, recapitalization, stock dividend, split-up, combination or exchange of shares, or the
like, the provisions contained in this Article 17 shall apply with equal force to additional and/or substitute securities, if any, received by the Employee in exchange for, or by virtue of his or her ownership of, Shares. 
  

 -5- 

 (c) Failure to Deliver Shares: In the event the Notice Recipient fails or refuses to deliver on a
timely basis duly endorsed certificates representing Shares to be sold pursuant to this Article 17, the Offeror shall have the right to deposit the purchase price for the Shares in a special account with any bank or trust company in the Commonwealth
of Massachusetts, giving notice of such deposit to the Notice Recipient, whereupon such Shares shall be deemed to have been purchased by the Offeror. All such monies shall be held by the bank or trust company for the benefit of the Notice Recipient.
All monies deposited with the bank or trust company but remaining unclaimed for two (2) years after the date of deposit shall be repaid by the bank or trust company to the Company on demand, and the Notice Recipient shall thereafter look only
to the Company for payment. 
 (d) Expiration of Drag Along Right: The drag along right set forth above shall remain in effect until
the effective date of the Initial Public Offering, if any, at which time the drag along right set forth herein will automatically expire. 
 18. No Exercise of Option if Employment Terminated for Misconduct. If the employment of the Employee is terminated for “Misconduct”, this option shall terminate on the date of such termination of employment and shall
thereupon not be exercisable to any extent whatsoever. “Misconduct” is conduct, as determined by the Board, involving one or more of the following: (i) the commission of an act of embezzlement, fraud, dishonesty or deliberate
disregard of the rules or policies of the Company which results in material loss, damage or injury to the Company, whether directly or indirectly; (ii) the unauthorized disclosure of any trade secret or confidential information of the Company;
or (iii) the breach by the Employee of any agreement with the Company, including without limitation of any noncompetition agreement between the Employee and the Company. In making such determination, the Board shall act fairly and in good faith
and shall give the Employee an opportunity to appear and to be heard at a hearing before the Board and present evidence on his behalf. For the purposes of this Article 18, termination of employment shall be deemed to occur when the Employee receives
notice that his employment is terminated. 
 19. Company’s Right of Repurchase. 
 (a) Rights of Repurchase: If any of the events specified in Article 19(b) below occur, then at any time after the occurrence of such event, the
Company shall have the option, but not the obligation, to repurchase all or any of the Shares acquired by the Employee upon exercise of this option from the Employee, or his legal representatives, successors, assigns or transferees, as the case may
be (the “Repurchase Option”). The Repurchase Option shall be exercised by the Company by giving the Employee, or his legal representative, written notice of its intention to exercise the Repurchase Option and the effective date of such
repurchase (the “Exercise Notice”). The price to be paid for the Shares by the Company under the Repurchase Option shall be: (A) in the case of the 
  

 -6- 

 occurrence of an event specified in paragraphs (i), (ii) or (iii) of Article 19(b), the Fair Value, as defined
in Article 19(c), of the Shares as of the effective date set forth in the Exercise Notice; and (B) in the case of the occurrence of the event specified in paragraph (iv) of Article 19(b), the option price of the Shares. The aforementioned
price shall be paid by the Company to the Employee, or his legal representative, within 30 days following the date of exercise of the Repurchase Option. The Company may, in exercising the Repurchase Option, designate one or more nominees to purchase
the Shares either within or without the Company. No later than the effective date set forth in the Exercise Notice, the Employee, or his legal representative, shall deliver to the Company the stock certificate or certificates representing the Shares
being repurchased, duly endorsed and free and clear of any and all liens, charges and encumbrances. 
 If Shares are not purchased under the
Repurchase Option, the Employee and his successor in interest, if any, will hold any such Shares in his possession subject to all of the provisions of this Agreement. 
 (b) Company’s Right to Exercise Repurchase Option: The Company shall have the Repurchase Option in the event that any of the following events shall occur: 
 (i) The termination of the Employee’s employment with the Company or any Related Corporation (as defined in the Plan), voluntarily or involuntarily,
for any reason whatsoever (other than Misconduct), including death or permanent disability; 
 (ii) The receivership, bankruptcy or other
creditor’s proceeding regarding the Employee or the taking of any of Employee’s Shares acquired upon exercise of this option by legal process, such as a levy of execution; 
 (iii) Distribution of Shares held by the Employee to his spouse as such spouse’s joint or community interest pursuant to a decree of dissolution,
operation of law, divorce, property settlement agreement or for any other reason, except as may be otherwise permitted by the Company; or 
 (iv) The termination of the Employee’s employment with the Company or any Related Corporation for Misconduct. 
 Notwithstanding anything to the contrary contained herein, in the case of the occurrence of an event specified in paragraph (i) of this Article 19(b), the Company shall not exercise the Repurchase Option unless and until the Employee
has held the Shares to be purchased under the Repurchase Option for a period of at least six months. 
 (c) Determination of Fair
Value: The “Fair Value” of each of the Shares subject to the Repurchase Option shall be the fair value of the Shares as of the date of the Company’s election to exercise the Repurchase Option, as determined by the Company in its
sole and reasonable discretion, assuming an arms’ length sale at open market value, taking into account any discount applicable to a minority interest and/or illiquidity. 
  

 -7- 

 (d) Expiration of Repurchase Option: The Repurchase Option set forth above shall remain in effect
until the effective date of an Initial Public Offering, if any, at which time the Repurchase Option shall terminate. 
 20. Lock-up
Agreement. The Employee agrees that the Employee will not, for a period of at least 180 days following the effective date of the Company’s initial distribution of securities in an underwritten public offering to the general public pursuant
to a registration statement filed with the Securities and Exchange Commission (the “Initial Public Offering”), directly or indirectly, sell, offer to sell or otherwise dispose of the Company’s securities other than any securities
which are included in such initial public offering. If the managing underwriter of any such Initial Public Offering determines that a shorter time period is appropriate, the aforementioned 180 day period may be shortened consistent with the
requirements of such managing underwriter. 
 21. Provision of Documentation to Employee. By signing this Agreement the Employee
acknowledges receipt of a copy of this Agreement and a copy of the Company’s 2004 Stock Option Plan. 
 22. Governing Law. This
Agreement shall be governed by and interpreted in accordance with the internal laws of the Commonwealth of Massachusetts. 
 IN WITNESS
WHEREOF the Company and the Employee have caused this instrument to be executed, and the Employee whose signature appears below acknowledges receipt of a copy of the Plan and acceptance of an original copy of this Agreement. 
  

					
	  
	 	LeMaitre Vascular, Inc.
	Employee	 		 	
	  
	 	By:	 	  

	Print Name of Employee	 		 	
	  
	 	Title:	 	  

	Street Address	 		 	
	  
	 		 	
	City                         State
                    Zip Code	 		 	

 NOTE: PERSON SIGNING ON BEHALF OF THE COMPANY MUST INITIAL ONE OF THE TWO CLAUSES UNDER ARTICLE 7 ABOVE.

  

 -8- 

 FORM OF 2004 STOCK OPTION PLAN NON-QUALIFIED STOCK OPTION AGREEMENT 
 Optionee’s Last Name:
                             
 LEMAITRE VASCULAR, INC. 
 Non-Qualified Stock Option Agreement 
 LeMaitre Vascular, Inc., a Delaware corporation (the “Company”), hereby grants this     day of
                    ,             , to
                            (the “Optionee”), in consideration of the Optionee’s
continued service the Company as a director, an option to purchase a maximum of              shares (individually, a “Share”, and collectively, the “Shares”) of
its Common Stock, $.01 par value (the “Common Stock”), at the price of $         per Share on the following terms and conditions: 
 1. Grant Under 2004 Stock Option Plan. This option is granted pursuant to and is governed by the Company’s 2004 Stock Option Plan (the
“Plan”) and, unless the context otherwise requires, terms used herein shall have the same meaning as in the Plan. Determinations made in connection with this option pursuant to the Plan shall be governed by the Plan as it exists on this
date. The Plan was approved by the Company’s stockholders on May 6, 2004. 
 2. Grant of Non-Qualified Stock Option; Other
Options. This option is not intended to qualify as an incentive stock option under Section 422(b) of the Internal Revenue Code of 1986. This option is in addition to any other options heretofore or hereafter granted to the Optionee
by the Company, but a duplicate original of this instrument shall not affect the grant of another option. 
 3. Extent of Option if
Service Continues. If the Optionee has continued to serve as a consultant to the Company on the applicable dates, the Optionee may exercise this option for the following number of Shares:
            . The foregoing rights are cumulative and, while the Optionee continues to serve as a director of the Company, may be exercised on or before
                    ,             . All of the foregoing rights are subject
to Articles 4 and 5, as appropriate, if the Optionee ceases to serve as a director of the Company or dies or becomes disabled during the Optionee’s term of service to the Company. 
  

 -1- 

 4. Termination of Service. If the Optionee ceases to serve as a director of the Company, other
than by reason of death or disability as defined in Article 5, no further installments of this option shall become exercisable following the date of such cessation of service and this option shall terminate after the passage of ninety (90) days
from the date service ceases, but in no event later than the scheduled expiration date. In such a case, the Optionee’s only rights hereunder shall be those which are properly exercised before the termination of this option. 
 5. Death; Disability. If the Optionee dies during the Optionee’s term of service to the Company, this option may be exercised, to the extent
of the number of shares with respect to which the Optionee could have exercised it on the date of his death, by his estate, personal representative or beneficiary to whom this option has been assigned pursuant to Article 10, at any time within 180
days after the date of death, but not later than the scheduled expiration date. If the Optionee ceases to serve as a director of the Company by reason of his disability (as defined in the Plan), this option may be exercised, to the extent of the
number of shares with respect to which he could have exercised it on the date of the termination of his service, at any time within one (1) year after such termination, but not later than the scheduled expiration date. At the expiration of
either such 180-day or one year period or the scheduled expiration date, whichever is the earlier, this option shall terminate and the only rights hereunder shall be those as to which the option was properly exercised before such termination.

 6. Partial Exercise. Exercise of this option up to the extent above stated may be made in part at any time and from time to time
within the above limits, except that this option may not be exercised for a fraction of a share unless such exercise is with respect to the final installment of stock subject to this option and a fractional share (or cash in lieu thereof) must be
issued to permit the Optionee to exercise completely such final installment. Any fractional share with respect to which an installment of this option cannot be exercised because of the limitation contained in the preceding sentence shall remain
subject to this option and shall be available for later purchase by the Optionee in accordance with the terms hereof. 
 7. Payment of
Price. The option price is payable in United States dollars and may be paid: 
 (a) either (i) in cash, (ii) by check, or
(iii) any combination of the foregoing, equal in amount to the option price. 
  

	
	  
 (Initials)

 (b) either (i) in cash, (ii) by check, (iii) after the Company’s Initial
Public Offering (as defined in Article 20) at a time when the Common Stock is publicly traded, by delivery of shares of the Company’s Common Stock, which have been owned by the 
  

 -2- 

 Optionee for a minimum period of six months, having an aggregate fair market value (as determined in accordance with the
Plan) equal as of the date of exercise to the option price, or (iv) by any combination of the foregoing, equal in amount to the option price. 
  

	
	  
 (Initials)

 8. Agreement to Purchase for Investment. By acceptance of this option, the Optionee
agrees that a purchase of Shares under this option will not be made with a view to their distribution, as that term is used in the Securities Act of 1933, as amended, and that he will not sell, transfer, pledge or otherwise dispose of such shares
unless in the opinion of counsel to the Company such sale, transfer, pledge or other disposition is in compliance with or exempt from the registration and prospectus requirements of that Act. Furthermore, the Optionee agrees to sign a certificate to
the foregoing effect at the time of exercising this option and agrees that the certificate for the Shares so purchased may be inscribed with a legend to ensure compliance with this Article 8, Article 10 and the Securities Act of 1933. 
 9. Method of Exercising Option. Subject to the terms and conditions of this Agreement, this option may be exercised by written notice to the
Company, at the principal executive office of the Company, or to such transfer agent as the Company shall designate. Such notice shall state the election to exercise this option and the number of Shares in respect of which it is being exercised (or
that an election is being made to purchase the maximum number of Shares so purchasable in accordance with the last paragraph of Article 7) and shall be signed by the person or persons so exercising this option. Such notice shall be accompanied by
payment of the full purchase price of such Shares. The Company shall deliver a certificate or certificates representing such Shares as soon as practicable after the notice shall be received. The certificate or certificates for the Shares as to which
this option shall have been so exercised shall be registered in the name of the person or persons so exercising this option (or, if this option shall be exercised by the Optionee and if the Optionee shall so request in the notice exercising this
option, shall be registered in the name of the Optionee and another person jointly, with right of survivorship) and shall be delivered as provided above to or upon the written order of the person or persons exercising this option. In the event this
option shall be exercised, pursuant to Article 5 hereof, by any person or persons other than the Optionee, such notice shall be accompanied by appropriate proof of the right of such person or persons to exercise this option. All Shares that shall be
purchased upon the exercise of this option as provided herein shall be fully paid and non-assessable. 
 10. Transfer Restrictions.

 (a) Restriction on Transfer of Shares. The Optionee may not sell, assign, transfer or otherwise dispose of any Shares at any time
prior to the effective date of an Initial Public Offering, except: (i) with the prior written consent of and subject to such conditions as may be imposed by the Board; (ii) by will or by the laws of descent and 
  

 -3- 

 distribution; or (iii) pursuant to Article 17 or Article 19. Unless otherwise agreed to in writing by the Company,
any sale, assignment, transfer or disposition hereunder shall continue to be subject to Sections 17 and 19 hereof to the same extent as if the Shares continued to be owned by the Optionee. 
 (b) Restriction on Transfer/Exercise of Option. This option is not transferable or assignable except by will or by the laws of descent and
distribution. During the Optionee’s lifetime only the Optionee can exercise this option. 
 11. No Obligation to Exercise Option.
The grant and acceptance of this option imposes no obligation on the Optionee to exercise it. 
 12. No Obligation to Continue
Service. The Company and any Related Corporation (as defined in the Plan) are not by the Plan or this option obligated to continue to retain the Optionee as a director of the Company, or in any other capacity, for any period of time. 

13. No Rights as Stockholder until Exercise. The Optionee shall have no rights as a stockholder with respect to Shares subject to this
Agreement until a stock certificate therefor has been issued to the Optionee and is fully paid for. Except as is expressly provided in the Plan with respect to certain changes in the capitalization of the Company, no adjustment shall be made for
dividends or similar rights for which the record date is prior to the date such stock certificate is issued. 
 14. Capital Changes and
Business Successions. The Plan contains provisions covering the treatment of options in a number of contingencies such as stock splits, mergers and sales of the Company’s stock or assets. Provisions in the Plan for adjustment with respect
to stock subject to options and the related provisions with respect to successors to the business of the Company are hereby made applicable hereunder and are incorporated herein by reference. In general, you should not assume that options
necessarily would survive the acquisition of the Company. In particular, without affecting the generality of the foregoing, it is understood that for the purposes of Articles 3 through 5 hereof, both inclusive, service to the Company includes
service in a comparable capacity to a Related Corporation as defined in the Plan. 
 15. INTENTIONALLY OMITTED 
 16. Withholding Taxes. The Optionee hereby agrees that the Company may withhold from any amounts payable to the Optionee the appropriate amount of
federal, state and local withholding taxes attributable to the Optionee’s exercise of this Option. At the Company’s discretion, the amount required to be withheld may be withheld in cash or (with respect only to the minimum amount required
to be withheld from the Employee under applicable law due to compensation income attributable to the exercise of this option) in kind from the Common Stock otherwise deliverable to the Optionee (or other person or persons) on exercise of this
Option. The Optionee further agrees that, if the 
  

 -4- 

 Company does not (at its election) withhold an amount from the Optionee sufficient to satisfy the Company’s
withholding obligation, the Optionee will reimburse the Company on demand, in cash, for the amount underwithheld, and that the Company may decline to issue the Shares issuable upon exercise of the Option hereunder until provision satisfactory to the
Company for such reimbursement has been made 
 17. Drag Along Right. 
 (a) Exercise of Right: If one or more persons who own in the aggregate more than 50% of the then outstanding shares of Common Stock of the Company
shall obtain a bona fide offer for the purchase of more than 50% of the outstanding Common Stock of the Company from an offeror (the “Offeror”), such person(s) shall have the right to require, by written notice (the “Drag Along
Notice”), any person who holds Shares pursuant to this Agreement (the “Notice Recipient”) to cause all of the Shares acquired under this option to be transferred to the Offeror, on the same terms and conditions (including without
limitation, per share price) applicable to, and at the same time as, the transfer to the Offeror by the person(s) giving the Drag Along Notice. If the sale to the Offeror has not occurred within 180 days following the date of the Drag Along Notice,
the Notice Recipient shall be released from his obligation under the Drag Along Notice, and it shall be necessary for a new and separate Drag Along Notice to be furnished and the terms and provisions of this Article 17 to be separately complied with
in order to consummate such a sale pursuant to this Article 17, unless the failure to complete such sale resulted from any failure by the Notice Recipient. Each Notice Recipient shall take or cause to be taken all such actions as may be reasonably
requested in order to expeditiously consummate a sale pursuant to this Article 17. 
 (b) Adjustments for Changes in Capital
Structure: If there shall be any change in the Common Stock of the Company through merger, consolidation, reorganization, recapitalization, stock dividend, split-up, combination or exchange of shares, or the like, the provisions contained in
this Article 17 shall apply with equal force to additional and/or substitute securities, if any, received by the Optionee in exchange for, or by virtue of his or her ownership of, Shares. 
 (c) Failure to Deliver Shares: In the event the Notice Recipient fails or refuses to deliver on a timely basis duly endorsed certificates
representing Shares to be sold pursuant to this Article 17, the Offeror shall have the right to deposit the purchase price for the Shares in a special account with any bank or trust company in the Commonwealth of Massachusetts, giving notice of such
deposit to the Notice Recipient, whereupon such Shares shall be deemed to have been purchased by the Offeror. All such monies shall be held by the bank or trust company for the benefit of the Notice Recipient. All monies deposited with the bank or
trust company but remaining unclaimed for two (2) years after the date of deposit shall be repaid by the bank or trust company to the Company on demand, and the Notice Recipient shall thereafter look only to the Company for payment. 

 

 -5- 

 (d) Expiration of Drag Along Right: The drag along right set forth above shall remain in effect
until the effective date of the Initial Public Offering, if any, at which time the drag along right set forth herein will automatically expire. 
 18. No Exercise of Option if Service Terminated for Misconduct. If the service of the Optionee on the Board is terminated for “Misconduct”, this option shall terminate on the date of such termination and shall thereupon not
be exercisable to any extent whatsoever. “Misconduct” is conduct, as determined by the Board, involving one or more of the following: (i) the commission of an act of embezzlement, fraud or dishonesty which results in material loss,
damage or injury to the Company, whether directly or indirectly; or (ii) the unauthorized disclosure of any trade secret or confidential information of the Company in violation of any nondisclosure or confidentiality agreement with the Company.
In making such determination, the Board shall act fairly and in good faith and shall give the Optionee an opportunity to appear and to be heard at a hearing before the Board and present evidence on his behalf. For the purposes of this Article 18,
termination of service for Misconduct shall be deemed to occur when the Optionee receives notice that his service as a director of the Company is terminated for Misconduct. 
 19. Company’s Right of Repurchase. 
 (a) Rights of Repurchase: If any of the events specified in Article 19(b) below occur, then at any time after the occurrence of such event, the Company shall have the option, but not the obligation, to repurchase all or any of the
Shares acquired by the Optionee upon exercise of this option from the Optionee, or his legal representatives, successors, assigns or transferees, as the case may be (the “Repurchase Option”). The Repurchase Option shall be exercised by the
Company by giving the Optionee, or his legal representative, written notice of its intention to exercise the Repurchase Option and the effective date of such repurchase (the “Exercise Notice”). The price to be paid for the Shares by the
Company under the Repurchase Option shall be: (A) in the case of the occurrence of an event specified in paragraphs (i), (ii) or (iii) of Article 19(b), the Fair Value, as defined in Article 19(c), of the Shares as of the effective
date set forth in the Exercise Notice; and (B) in the case of the occurrence of the event specified in paragraph (iv) of Article 19(b), the option price of the Shares. The aforementioned price shall be paid by the Company to the Optionee,
or his legal representative, within 30 days following the date of exercise of the Repurchase Option. The Company may, in exercising the Repurchase Option, designate one or more nominees to purchase the Shares either within or without the Company. No
later than the effective date set forth in the Exercise Notice, the Optionee, or his legal representative, shall deliver to the Company the stock certificate or certificates representing the Shares being repurchased, duly endorsed and free and clear
of any and all liens, charges and encumbrances. 
 If Shares are not purchased under the Repurchase Option, the Optionee and his successor in
interest, if any, will hold any such Shares in his possession subject to all of the provisions of this Agreement. 
  

 -6- 

 (b) Company’s Right to Exercise Repurchase Option: The Company shall have the Repurchase
Option in the event that any of the following events shall occur: 
 (i) The termination of the Optionee’s service to the Company or any
Related Corporation (as defined in the Plan), voluntarily or involuntarily, for any reason whatsoever (other than Misconduct), including death or permanent disability; 
 (ii) The receivership, bankruptcy or other creditor’s proceeding regarding the Optionee or the taking of any of Optionee’s Shares acquired upon exercise of this option by legal process, such as a levy of
execution; 
 (iii) Distribution of Shares held by the Optionee to his spouse as such spouse’s joint or community interest pursuant to a
decree of dissolution, operation of law, divorce, property settlement agreement or for any other reason, except as may be otherwise permitted by the Company; or 
 (iv) The termination of the Optionee’s service to the Company or any Related Corporation for Misconduct. 
 Notwithstanding anything to the contrary contained herein, in the case of the occurrence of an event specified in paragraph (i) of this Article 19(b), the Company shall not exercise the Repurchase Option unless and until the Optionee
has held the Shares to be purchased under the Repurchase Option for a period of at least six months. 
 (c) Determination of Fair
Value: The “Fair Value” of each of the Shares subject to the Repurchase Option shall be the fair value of the Shares as of the date of the Company’s election to exercise the Repurchase Option, as determined by the Company in its
sole and reasonable discretion, assuming an arms’ length sale at open market value, taking into account any discount applicable to a minority interest and/or illiquidity. 
 (d) Expiration of Repurchase Option: The Repurchase Option set forth above shall remain in effect until the effective date of an Initial Public
Offering, if any, at which time the Repurchase Option shall terminate. 
 20. Lock-up Agreement. The Optionee agrees that the Optionee
will not, for a period of at least 180 days following the effective date of the Company’s initial distribution of securities in an underwritten public offering to the general public pursuant to a registration statement filed with the Securities
and Exchange Commission (the “Initial Public Offering”), directly or indirectly, sell, offer to sell or otherwise dispose of the Company’s securities other than any securities which are included in such initial public offering. If the
managing underwriter of any such Initial Public Offering determines that a shorter time period is appropriate, the aforementioned 180 day period may be shortened consistent with the requirements of such managing underwriter. 
  

 -7- 

 21. Provision of Documentation to Optionee. By signing this Agreement the Optionee acknowledges
receipt of a copy of this Agreement and a copy of the Company’s 2004 Stock Option Plan. 
 22. Governing Law. This Agreement
shall be governed by and interpreted in accordance with the internal laws of the Commonwealth of Massachusetts. 
 IN WITNESS WHEREOF the
Company and the Optionee have caused this instrument to be executed, and the Optionee whose signature appears below acknowledges receipt of a copy of the Plan and acceptance of an original copy of this Agreement. 
  

					
	  
	 	LeMaitre Vascular, Inc.
	 Optionee
	 		 	
	  
	 	By:	 	  

	 Print Name of Optionee
	 		 	
	  
	 	Title:	 	  

	 Street Address
	 		 	
	  
	 		 	
	 City                     State
                        Zip Code
	 		 	

 NOTE: PERSON SIGNING ON BEHALF OF THE COMPANY MUST INITIAL ONE OF THE TWO CLAUSES UNDER ARTICLE 7 ABOVE.

  

 -8-Indenture due 2011

 EXHIBIT 4.1 
 GILEAD SCIENCES, INC. 
 0.50% Convertible Senior Notes due 2011 
 INDENTURE 
 Dated as of
April 25, 2006 
 WELLS FARGO BANK, NATIONAL ASSOCIATION, 
 Trustee 

 CROSS REFERENCE TABLE* 
  

	*	Note: This Cross Reference Table shall not, for any purpose, be deemed to be part of the Indenture. 

  

			
	 TIA Section
	  	Indenture Section
	310(a)(1)	  	7.10
	      (a)(2)	  	7.10
	      (a)(3)	  	N.A.
	      (a)(4)	  	N.A.
	      (b)	  	7.08; 7.10
	      (c)	  	N.A.
	311(a)	  	N.A.
	      (b)	  	N.A.
	      (c)	  	N.A.
	312(a)	  	2.05
	      (b)	  	12.03
	      (c)	  	12.03
	313(a)	  	7.06
	      (b)(1)	  	N.A.
	      (b)(2)	  	7.06
	      (c)	  	12.02
	      (d)	  	7.06
	314(a)	  	4.02; 4.03; 12.02
	      (b)	  	N.A.
	      (c)(1)	  	12.04
	      (c)(2)	  	12.04
	      (c)(3)	  	N.A.
	      (d)	  	N.A.
	      (e)	  	12.05
	      (f)	  	N.A.
	315(a)	  	7.01
	      (b)	  	7.05; 12.02
	      (c)	  	7.01
	      (d)	  	7.01
	      (e)	  	6.11
	316(a) (last sentence)	  	2.08
	      (a)(1)(A)	  	6.05
	      (a)(1)(B)	  	6.04
	      (a)(2)	  	N.A.
	      (b)	  	6.07
	317(a)(1)	  	6.08
	      (a)(2)	  	6.09
	      (b)	  	2.04
	318(a)	  	12.01

 N.A. means not applicable. 
  

 i 

 TABLE OF CONTENTS 
  

					
	 	  	 	  	Page
		
	ARTICLE 1 DEFINITIONS AND INCORPORATION BY REFERENCE	  	
			
	Section 1.01.	  	Definitions	  	1
	Section 1.02.	  	Other Definitions	  	8
	Section 1.03.	  	Incorporation by Reference of Trust Indenture Act	  	8
	Section 1.04.	  	Rules of Construction	  	9
	Section 1.05.	  	Acts of Holders	  	9
		
	ARTICLE 2 THE SECURITIES	  	
			
	Section 2.01.	  	Form and Dating	  	10
	Section 2.02.	  	Execution and Authentication	  	12
	Section 2.03.	  	Registrar, Paying Agent and Conversion Agent	  	13
	Section 2.04.	  	Paying Agent to Hold Money and Securities in Trust	  	13
	Section 2.05.	  	Securityholder Lists	  	13
	Section 2.06.	  	Transfer and Conversion	  	14
	Section 2.07.	  	Replacement Securities	  	15
	Section 2.08.	  	Outstanding Securities; Determinations of Holders’ Action	  	15
	Section 2.09.	  	Temporary Securities	  	16
	Section 2.10.	  	Cancellation	  	17
	Section 2.11.	  	Persons Deemed Owners	  	17
	Section 2.12.	  	Legend; Additional Transfer and Exchange Requirements	  	17
	Section 2.13.	  	CUSIP Numbers	  	23
		
	ARTICLE 3 PURCHASES	  	
			
	Section 3.01.	  	Purchase of Securities at Option of the Holder Upon Change in Control	  	23
	Section 3.02.	  	Effect of Change in Control Purchase Notice	  	26
	Section 3.03.	  	Deposit of Change in Control Purchase Price	  	27
	Section 3.04.	  	Securities Purchased in Part	  	27
	Section 3.05.	  	Covenant to Comply With Securities Laws Upon Purchase of Securities	  	27
	Section 3.06.	  	Repayment to the Company	  	27
		
	ARTICLE 4 COVENANTS	  	
			
	Section 4.01.	  	Payment of Securities	  	28
	Section 4.02.	  	SEC and Other Reports	  	28
	Section 4.03.	  	Compliance Certificate	  	29
	Section 4.04.	  	Maintenance of Office or Agency	  	29

  

 i 

					
		
	ARTICLE 5 SUCCESSOR CORPORATION	  	
			
	 Section 5.01.
	  	When Company May Merge or Transfer Assets	  	29
		
	ARTICLE 6 DEFAULTS AND REMEDIES	  	
			
	 Section 6.01.
	  	Events of Default	  	30
	 Section 6.02.
	  	Acceleration	  	32
	 Section 6.03.
	  	Other Remedies	  	32
	 Section 6.04.
	  	Waiver of Past Defaults	  	32
	 Section 6.05.
	  	Control by Majority	  	33
	 Section 6.06.
	  	Limitation on Suits	  	33
	 Section 6.07.
	  	Rights of Holders to Receive Payment	  	33
	 Section 6.08.
	  	Collection Suit by Trustee	  	34
	 Section 6.09.
	  	Trustee May File Proofs of Claim	  	34
	 Section 6.10.
	  	Priorities	  	34
	 Section 6.11.
	  	Undertaking for Costs	  	35
	 Section 6.12.
	  	Waiver of Stay, Extension or Usury Laws	  	35
		
	ARTICLE 7 TRUSTEE	  	
			
	 Section 7.01.
	  	Duties of Trustee	  	35
	 Section 7.02.
	  	Rights of Trustee	  	37
	 Section 7.03.
	  	Individual Rights of Trustee	  	38
	 Section 7.04.
	  	Trustee’s Disclaimer	  	38
	 Section 7.05.
	  	Notice of Defaults	  	39
	 Section 7.06.
	  	Reports by Trustee to Holders	  	39
	 Section 7.07.
	  	Compensation and Indemnity	  	39
	 Section 7.08.
	  	Replacement of Trustee	  	40
	 Section 7.09.
	  	Successor Trustee by Merger	  	41
	 Section 7.10.
	  	Eligibility; Disqualification	  	41
		
	ARTICLE 8 DISCHARGE OF INDENTURE	  	
			
	 Section 8.01.
	  	Discharge of Liability on Securities	  	41
	 Section 8.02.
	  	Repayment to the Company	  	41
		
	ARTICLE 9 AMENDMENTS	  	
			
	 Section 9.01.
	  	Without Consent of Holders	  	42
	 Section 9.02.
	  	With Consent of Holders	  	42
	 Section 9.03.
	  	Compliance with Trust Indenture Act	  	43
	 Section 9.04.
	  	Revocation and Effect of Consents, Waivers and Actions	  	43
	 Section 9.05.
	  	Notation on or Exchange of Securities	  	43
	 Section 9.06.
	  	Trustee to Sign Supplemental Indentures	  	44
	 Section 9.07.
	  	Effect of Supplemental Indentures	  	44

  

 ii 

					
		
	ARTICLE 10 CONVERSION	  	
			
	 Section 10.01.
	  	Conversion Privilege	  	44
	 Section 10.02.
	  	Conversion Procedure	  	45
	 Section 10.03.
	  	Fractional Shares	  	46
	 Section 10.04.
	  	Taxes on Conversion	  	46
	 Section 10.05.
	  	Company to Provide Stock	  	46
	 Section 10.06.
	  	Adjustment for Change in Capital Stock	  	47
	 Section 10.07.
	  	Adjustment for Rights Issue	  	47
	 Section 10.08.
	  	Adjustment for Other Distributions	  	48
	 Section 10.09.
	  	Adjustment for Cash Dividends	  	51
	 Section 10.10.
	  	Adjustment for Tender Offer	  	51
	 Section 10.11.
	  	Adjustment to Conversion Rate Upon Change in Control Transactions	  	52
	 Section 10.12.
	  	When Adjustment May Be Deferred	  	53
	 Section 10.13.
	  	When No Adjustment Required; Conversion Rate Cap	  	53
	 Section 10.14.
	  	Notice of Adjustment	  	54
	 Section 10.15.
	  	Notice of Certain Transactions	  	54
	 Section 10.16.
	  	Reorganization of Company; Special Distributions	  	54
	 Section 10.17.
	  	Company Determination Final	  	55
	 Section 10.18.
	  	Trustee’s Adjustment Disclaimer	  	55
	 Section 10.19.
	  	Simultaneous Adjustments	  	56
	 Section 10.20.
	  	Successive Adjustments	  	56
	 Section 10.21.
	  	Rights Issued in Respect of Common Stock Issued Upon Conversion	  	56
	 Section 10.22.
	  	Withholding Taxes for Adjustments in Conversion Rate	  	56
	 Section 10.23.
	  	Exchange in Lieu of Conversion	  	56
		
	ARTICLE 11 PAYMENT OF INTEREST	  	
			
	 Section 11.01.
	  	Interest Payments	  	57
	 Section 11.02.
	  	Defaulted Interest	  	58
	 Section 11.03.
	  	Interest Rights Preserved	  	59
		
	ARTICLE 12 MISCELLANEOUS	  	
			
	 Section 12.01.
	  	Trust Indenture Act Controls	  	59
	 Section 12.02.
	  	Notices; Address of Agency	  	59
	 Section 12.03.
	  	Communication by Holders with Other Holders	  	61
	 Section 12.04.
	  	Certificate and Opinion as to Conditions Precedent	  	61
	 Section 12.05.
	  	Statements Required in Certificate or Opinion	  	61
	 Section 12.06.
	  	Separability Clause	  	62
	 Section 12.07.
	  	Rules by Trustee, Paying Agent, Conversion Agent and Registrar	  	62
	 Section 12.08.
	  	Calculations	  	62
	 Section 12.09.
	  	Legal Holidays	  	62
	 Section 12.10.
	  	Governing Law	  	63
	 Section 12.11.
	  	No Recourse Against Others	  	63
	 Section 12.12.
	  	Successors	  	63
	 Section 12.13.
	  	Multiple Originals	  	63

  

 iii 

 INDENTURE dated as of April 25, 2006 between GILEAD SCIENCES, INC., a Delaware corporation (the
“Company”), and WELLS FARGO BANK, NATIONAL ASSOCIATION, a national banking association, as trustee (“Trustee”). 
 Each party agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders of the Company’s 0.50% Convertible Senior Notes due 2011 (the “Securities”): 
 ARTICLE 1 
 DEFINITIONS
AND INCORPORATION BY REFERENCE 
 Section 1.01. Definitions. 

“Additional Interest” means all additional interest owing on the Securities pursuant to the Registration Rights Agreement.

 “Affiliate” of any specified person means any other person directly or indirectly controlling or controlled by or under
direct or indirect common control with such specified person. For the purposes of this definition, “control” when used with respect to any specified person means the power to direct or cause the direction of the management and policies of
such person, directly or indirectly, whether through the ownership of voting securities, by contract or otherwise; and the terms “controlling” and “controlled” have meanings correlative to the foregoing. 
 “Applicable Conversion Rate” means the Conversion Rate on any Trading Day, as adjusted in accordance with Article 10. For purposes of
determining the Conversion Value, the Applicable Conversion Rate means the Conversion Rate on the Conversion Date. 
 “Applicable
Procedures” means, with respect to any transfer or transaction involving a Global Security or beneficial interest therein, the rules and procedures of the Depositary for such Security, in each case to the extent applicable to such
transaction and as in effect from time to time. 
 “Average Closing Price” means (1) with respect to distributions of
rights, warrants or options, the average of the Closing Prices per share of Common Stock for the five (5) consecutive Trading Days ending on the date immediately preceding the first public announcement of the distribution and (2) with
respect to other distributions, the average of the Closing Prices per share of Common Stock for the five (5) consecutive Trading Days ending on the date immediately preceding the Time of Determination. 
 If the Ex-Dividend Time (or in the case of a subdivision, combination or reclassification, the effective date with respect thereto) with respect to a
dividend, subdivision, combination or reclassification to which Section 10.06(1) or (2) applies occurs during the period applicable for calculating “Average Closing Price” pursuant to the definition in the preceding sentence,
“Average Closing Price” shall be calculated for such period in a manner determined by the Board of Directors to reflect the impact of such dividend, subdivision, combination or reclassification on the Closing Price of the Common Stock
during such period. 
  

 1 

 “Bankruptcy Law” means Title 11, United States Code, or any similar Federal or state law
for the relief of debtors. 
 “Board of Directors” means either the board of directors of the Company or any duly authorized
committee of such board. 
 “Business Day” means any weekday that is not a day on which banking institutions in the City of
New York, New York are authorized or obligated to close. 
 “Capital Stock” for any corporation means any and all shares,
interests, rights to purchase, warrants, options, participations or other equivalents of or interests in (however designated) stock issued by that corporation. 
 “Certificated Securities” means Securities that are substantially in the form of the Securities attached hereto as Exhibit A. 
 A “Change in Control” shall be deemed to have occurred at such time as either of the following events shall occur: 
 (1) any person or group, other than the Company, its Subsidiaries or any employee benefits plan of the Company or its Subsidiaries, files
a Schedule 13D or Schedule TO (or any successor schedule, form or report) pursuant to the Exchange Act, disclosing that such person has become the beneficial owner of 50% or more of the voting power of the Common Stock then outstanding or other
Capital Stock into which the Common Stock is reclassified or changed; provided, however, that a person shall not be deemed beneficial owner of, or to own beneficially, (A) any securities tendered pursuant to a tender or exchange offer
made by or on behalf of such person or any of such person’s Affiliates until such tendered securities are accepted for purchase or exchange thereunder, or (B) any securities if such beneficial ownership (1) arises solely as a result
of a revocable proxy delivered in response to a proxy or consent solicitation made pursuant to the applicable rules and regulations under the Exchange Act, and (2) is not also then reportable on Schedule 13D (or any successor schedule) under
the Exchange Act; or 
 (2) the Company consolidates with or merges with or into another person (other than a Subsidiary of
the Company), or sells, conveys, transfers or leases all or substantially all of its properties and assets to any person (other than a Subsidiary of the Company) or any person (other than a Subsidiary of the Company) consolidates with or merges with
or into the Company, and the outstanding Voting Stock of the Company is reclassified into, converted for or converted into the right to receive any other property or security, provided that none of these circumstances will be a Change in
Control if the persons that beneficially own the Voting Stock of the Company immediately prior to the transaction own, directly or indirectly, shares with a majority of the total voting power of all outstanding Voting Stock of the surviving or
transferee person that are entitled to vote generally in the election of that person’s board of directors, managers or trustees immediately after the transaction. 
  

 2 

 For purposes of defining a Change in Control: 
 (x) the term “person” and the term “group” have the meanings given by Section 13(d) and 14(d) of the Exchange Act
or any successor provisions; 
 (y) the term “group” includes any group acting for the purpose of acquiring, holding
or disposing of securities within the meaning of Rule 13d-5(b)(1) under the Exchange Act or any successor provision; and 
 (z) the term “beneficial owner” is determined in accordance with Rules 13d-3 and 13d-5 under the Exchange Act or any successor provisions, except that a person will be deemed to have beneficial ownership of all shares that
person has the right to acquire irrespective of whether that right is exercisable immediately or only after the passage of time. 
 Notwithstanding the foregoing, it will not constitute a Change in Control if at least 90% of the consideration for the Common Stock (excluding cash payments for fractional shares and cash payments made in respect of dissenter’s
appraisal rights and cash payment of the Required Cash Amount, if any) in the transaction or transactions constituting the Change in Control consists of common stock traded on a United States national securities exchange or quoted on The Nasdaq
National Market, or which will be so traded or quoted when exchanged in connection with the Change in Control, and as a result of such transaction or transactions the Securities become convertible solely into such common stock. 
 “Close of Business” means 5:00 p.m. (New York City time). 
 “Closing Price” of the Common Stock on any date means the closing per share sale price (or, if no closing sale price is reported, the average of the bid and ask prices or, if more than one in either
case, the average of the average bid and average ask prices) on such date as reported in composite transactions for the principal United States securities exchange on which the Common Stock is traded or, if the Common Stock is not listed on a United
States national or regional securities exchange, (i) as reported by the National Association of Securities Dealers Automated Quotation System or by the National Quotation Bureau Incorporated, or (ii) if such bid and ask prices are not
reported by the National Association of Securities Dealers Automated Quotation System or by the National Quotation Bureau Incorporated, in a manner to be determined by the Company on the basis of such quotation as the Company considers appropriate
in its sole and absolute discretion. 
 “Common Stock” means the shares of common stock, $0.001 par value, of the Company as
it exists on the date of this Indenture or any other shares of Capital Stock of the Company into which the Common Stock shall be reclassified or changed. 
 “Company” means the party named as the “Company” in the first paragraph of this Indenture until a successor replaces it pursuant to the applicable provisions of this Indenture and,
thereafter, shall mean such successor. The foregoing sentence shall likewise apply to any subsequent such successor or successors. 
  

 3 

 “Company Request” or “Company Order” means a written request or order
signed in the name of the Company by an Officer. 
 “Conversion Date” means the date on which the Holder of the Security has
complied with all requirements under this Indenture to convert such Security. 
 “Conversion Price” per share of Common
Stock as of any day means the result obtained by dividing $1,000 by the then Applicable Conversion Rate. 
 “Conversion
Rate” means the number of shares of Common Stock issuable upon conversion of a Security per $1,000 of Principal Amount thereof, subject to adjustment pursuant to Article 10. 
 “Conversion Reference Period” means (a) for Securities that are converted during the period beginning on the 30th day prior to the Maturity Date, the ten consecutive Trading Days beginning on the third Trading Day following the Maturity
Date and (b) in all other instances, the ten consecutive Trading Days beginning on the third Trading Day following the Conversion Date. 
 “Conversion Value” means the amount equal to the product of (a) the Applicable Conversion Rate multiplied by (b) the average of the Volume Weighted Average Price on each of the Trading Days during the Conversion
Reference Period. 
 “Corporate Trust Office” means the principal office of the Trustee at which at any time its corporate
trust business shall be administered, which office at the date hereof is located at 213 Court Street, Middletown, CT 06457, Attention: Corporate Trust Services, or such other address as the Trustee may designate from time to time by notice to the
Holders and the Company, or the principal corporate trust office of any successor Trustee (or such other address as a successor Trustee may designate from time to time by notice to the Holders and the Company). 
 “Custodian” means any receiver, trustee, assignee, liquidator, custodian or similar official under any Bankruptcy Law. 
 “Daily Share Amounts” means, for each Trading Day of the Conversion Reference Period and each $1,000 Principal Amount of Securities
surrendered for conversion, a number of shares of Common Stock (but in no event less than zero) determined by the following formula: 
  

								
	 (Volume Weighted Average Price per share
 of Common Stock for such Trading Day
	  	x	  	 Conversion Rate in effect
 on such Trading Day)
	  	- $	1,000
	 Volume Weighted Average Price per share of Common Stock for such
Trading
 Day x 10
	  		

 “Default” means any event which is, or after notice or passage of time or both
would be, an Event of Default. 
 “Depositary” means DTC or the nominee thereof, or any successor thereto. 
  

 4 

 “DTC” means The Depository Trust Company. 
 “Exchange Act” means the Securities Exchange Act of 1934, as amended. 
 “Global Securities” means Securities that are in the form of the Securities attached hereto as Exhibit A. 
 “Holder” means a person in whose name a Security is registered on the Registrar’s books. 
 “Indebtedness” means with respect to the Company at any date, without duplication, obligations (other than nonrecourse obligations) for
borrowed money or evidenced by bonds, debentures, notes or similar instruments. 
 “Indenture” means this Indenture, as
amended or supplemented from time to time in accordance with the terms hereof, including the provisions of the TIA that are deemed to be a part hereof. 
 “Initial Conversion Rate” means 12.9024 shares of Common Stock per Principal Amount of $1,000, subject to adjustment pursuant to Article 10. 
 “Interest Payment Date” means each date specified as such in paragraph 1 of the Securities. 
 “Issue Date” of any Security means the date on which the Security was originally issued or deemed issued as set forth on the face of the
Security. 
 “Market Disruption Event” means the occurrence or existence for more than one half hour period in the aggregate
on any scheduled Trading Day for the Common Stock of any suspension or limitation imposed on trading (by reason of movements in price exceeding limits permitted by the Nasdaq National Market or otherwise) in Common Stock or in any options, contracts
or future contracts relating to the Common Stock, and such suspension or limitation occurs or exists at any time before 1:00 p.m. (New York City time) on such day. 
 “Net Share Amount” means (i) the Remaining Shares after giving effect to any election by the Company to pay cash in lieu of all or a portion thereof pursuant to Section 10.01 and
(ii) any such cash. 
 “Officer” means the Chairman of the Board, the Vice Chairman, the Chief Executive Officer, the
President, any Executive Vice President, any Senior Vice President, any Vice President, the Treasurer or the Secretary or any Assistant Treasurer or Assistant Secretary of the Company. 
 “Officers’ Certificate” means a written certificate containing the information specified in Sections 12.04 and 12.05, signed in the
name of the Company by any two Officers, and delivered to the Trustee. One of the officers executing the Officers’ Certificate pursuant to Section 4.03 shall be the principal executive officer, financial officer or accounting officer of
the Company. 
  

 5 

 “Opinion of Counsel” means a written opinion containing the information specified in
Sections 12.04 and 12.05, from legal counsel who is acceptable to the Trustee. The counsel may be an employee of, or counsel to, the Company or the Trustee. 
 “Person” or “person” means any individual, corporation, limited liability company, partnership, joint venture, association, joint-stock company, trust, unincorporated organization, or
government or any agency or political subdivision thereof. 
 “Principal Amount” of a Security means the Principal Amount as
set forth on the face of the Security. 
 “Registration Rights Agreement” means the Registration Rights Agreement, dated as
of the date hereof, by and among the Company and Merrill Lynch, Pierce, Fenner & Smith Incorporated, Morgan Stanley & Co. Incorporated and Banc of America Securities LLC, as representatives of the Initial Purchasers. 
 “Regular Record Date” means, with respect to any Interest Payment Date, the April 15 or the October 15 immediately preceding
such Interest Payment Date. 
 “Responsible Officer” means, when used with respect to the Trustee, any officer within the
corporate trust department of the Trustee having direct responsibility for the administration of this Indenture. 
 “Restricted
Global Security” means a Global Security that is a Restricted Security. 
 “Restricted Security” means a Security
required to bear the Legend. 
 “Rule 144” means Rule 144 under the Securities Act or any successor to such Rule.

 “Rule 144A” means Rule 144A under the Securities Act or any successor to such Rule. 
 “SEC” means the Securities and Exchange Commission. 
 “Securities” means any of the Company’s 0.50% Convertible Senior Notes due 2011, as amended or supplemented from time to time, issued under this Indenture. 
 “Securities Act” means the Securities Act of 1933, as amended. 
 “Significant Subsidiary” means a “significant subsidiary”, as such term is defined in Rule 1-02 of Regulation S-X under the
Securities Act of 1933. 
 “Stated Maturity,” when used with respect to any Security or any installment of interest thereon,
means the date specified in such Security as the fixed date on which an amount equal to the Principal Amount of such Security or such installment of interest is due and payable. 
 “Subsidiary” means (i) a corporation, a majority of whose Voting Stock is, at the date of determination, directly or indirectly
owned by the Company, by one or more Subsidiaries of the Company, or by the Company and one or more Subsidiaries of the Company, (ii) a partnership in 

  

 6 

 
which the Company, a Subsidiary of the Company or the Company and one or more Subsidiaries of the Company, holds a majority interest in the equity capital or
profits of such partnership, or (iii) any other person (other than a corporation or a partnership) in which the Company, a Subsidiary of the Company, or the Company and one or more Subsidiaries of the Company, directly or indirectly, at the
date of determination, has (x) at least a majority ownership interest or (y) the power to elect or direct the election of a majority of the directors or trustees, as the case may be, or other governing body of such person. 
 “TIA” means the Trust Indenture Act of 1939 as in effect on the date of this Indenture, provided, however, that in the event the
TIA is amended after such date, TIA means, to the extent required by any such amendment, the TIA as so amended. 
 “Time of
Determination” means the time and date of the earlier of (i) the determination of stockholders entitled to receive rights, warrants or options or a distribution, in each case, to which Sections 10.07, 10.08 or 10.10 applies and
(ii) the time (“Ex-Dividend Time”) immediately prior to the commencement of “ex-dividend” trading for such rights, warrants or options or distribution on the Nasdaq National Market or such other national or regional
exchange or market on which the Common Stock is then listed or quoted. 
 “Trading Day” means any day on which
(i) there is no Market Disruption Event and (ii) the Nasdaq National Market or, if the Common Stock is not quoted on the Nasdaq National Market, the principal national securities exchange on which the Common Stock is listed, is open for
trading or, if the Common Stock is not so listed, admitted for trading or quoted, any Business Day. A Trading Day only includes those days that have a scheduled closing time of 4:00 p.m. (New York City time) or the then standard closing time for
regular trading on the relevant exchange or trading system. 
 “Trustee” means the party named as the “Trustee” in
the first paragraph of this Indenture until a successor replaces it pursuant to the applicable provisions of this Indenture and, thereafter, shall mean such successor. The foregoing sentence shall likewise apply to any subsequent such successor or
successors. 
 “Volume Weighted Average Price” means the price per share of the Common Stock on any Trading Day as displayed
on Bloomberg (or any successor service) page GILD <equity> VAP in respect of the period from 9:30 a.m. to 4:00 p.m. (New York City time), on such Trading Day; or, if such price is not available, the market value per share of the Common Stock
on such day as determined by a nationally recognized independent investment banking firm retained for this purpose by the Company. 
 “Voting Stock” means, with respect to any corporation, association, company or business trust, stock or other securities of the class or classes having general voting power under ordinary circumstances to elect at least a
majority of the board of directors, managers or trustees of such corporation, association, company or business trust, provided that, for the purposes hereof, stock or other securities which carry only the right to vote conditionally on the
happening of an event shall not be considered Voting Stock whether or not such event shall have happened. 
  

 7 

 Section 1.02. Other Definitions. 
  

			
	 Term
	  	Defined in Section
	 “Act”
	  	1.05
	 “Agent Members”
	  	2.12(e)
	 “Cash Percentage”
	  	10.01
	 “Cash Percentage Notice”
	  	10.01
	 “Change in Control”
	  	3.01(a)
	 “Change in Control Effective Date”
	  	10.11
	 “Change in Control Purchase Date”
	  	3.01(a)
	 “Change in Control Purchase Notice”
	  	3.01(c)
	 “Change in Control Purchase Price”
	  	3.01(a)
	 “Conversion Agent”
	  	2.03(a)
	 “Defaulted Interest”
	  	11.02
	 “Event of Default”
	  	6.01
	 “Ex-Dividend Date”
	  	10.08(b)
	 “Ex-Dividend Time”
	  	Definition of “Time of
Determination”
	 “Expiration Time”
	  	10.10
	 “Financial Institution”
	  	10.23
	 “Initial Purchasers”
	  	2.01
	 “Legal Holiday”
	  	12.09
	 “Legend”
	  	2.12(a)
	 “Make-Whole Shares”
	  	10.11
	 “Notice of Default”
	  	6.01
	 “Paying Agent”
	  	2.03(a)
	 “Post-Distribution Price”
	  	10.08(b)
	 “Protected Purchaser”
	  	2.07
	 “Purchase Agreement”
	  	2.01
	 “Purchased Shares”
	  	10.10
	 “Registrar”
	  	2.03(a)
	 “Remaining Shares”
	  	10.01
	 “Required Cash Amount”
	  	10.01
	 “Resale Restriction Termination Date”
	  	2.12(f)
	 “Rights”
	  	10.21
	 “Rights Plan”
	  	10.21
	 “Stock Price”
	  	10.11

 Section 1.03. Incorporation by Reference of Trust Indenture Act. 
 Whenever this Indenture refers to a provision of the TIA, the provision is incorporated by reference in and made a part of this Indenture. The following
TIA terms used in this Indenture have the following meanings: 
 “Commission” means the SEC. 
 “indenture securities” means the Securities. 
  

 8 

 “indenture security holder” means a Holder. 
 “indenture to be qualified” means this Indenture. 
 “indenture trustee” or “institutional trustee” means the Trustee. 
 “obligor” on the indenture securities means the Company. 
 All other TIA terms used in this Indenture that are
defined by the TIA, defined by TIA reference to another statute or defined by SEC rule have the meanings assigned to them by such definitions. 
 Section 1.04. Rules of Construction. 
 Unless the context otherwise requires: 
 (i) a term has the meaning assigned to it; 
 (ii) an accounting term not otherwise defined has the meaning assigned to it in accordance with United States generally accepted accounting principles as in effect from time to time; 
 (iii) “or” is not exclusive; 
 (iv) “including” means including, without limitation; and 
 (v) words in the singular include the plural, and words in
the plural include the singular. 
 Section 1.05. Acts of Holders. 
 Any request, demand, authorization, direction, notice, consent, waiver or other action provided by this Indenture to be given or taken by Holders may be
embodied in and evidenced by one or more instruments (which may take the form of an electronic writing or messaging or otherwise be in accordance with customary procedures of the Depositary or the Trustee) of substantially similar tenor signed by
such Holders in person or by agent duly appointed in writing (which may be in electronic form); and, except as herein otherwise expressly provided, such action shall become effective when such instrument or instruments are delivered to the Trustee
and, where it is hereby expressly required, to the Company. Such instrument or instruments (and the action embodied therein and evidenced thereby) are herein sometimes referred to as the “Act” of Holders signing such instrument or
instruments. Proof of execution of any such instrument or of a writing appointing any such agent (either of which may be in electronic form) shall be sufficient for any purpose of this Indenture and conclusive in favor of the Trustee and the
Company, if made in the manner provided in this Section. 
 (i) The fact and date of the execution by any Person of any such instrument or
writing may be proved by the affidavit of a witness of such execution (or electronic delivery) or by a certificate of a notary public or other officer authorized by law to take acknowledgments of 

  

 9 

 
deeds, certifying that the individual signing or delivering such instrument or writing acknowledged to such officer the execution thereof (or electronic
delivery). Where such execution is by a signer acting in a capacity other than such signer’s individual capacity, such certificate or affidavit shall also constitute sufficient proof of such signer’s authority. The fact and date of the
execution of any such instrument or writing (electronic or otherwise), or the authority of the Person executing the same, may also be proved in any other manner which the Trustee deems sufficient. 
 (ii) The ownership of Securities shall be proved by the register for the Securities maintained by the Registrar. 
 (iii) Any request, demand, authorization, direction, notice, consent, waiver or other Act of the Holder of any Security shall bind every future Holder of
the same Security and the holder of every Security issued upon the registration of transfer thereof or in exchange therefor or in lieu thereof in respect of anything done, omitted or suffered to be done by the Trustee or the Company in reliance
thereon, whether or not notation of such action is made upon such Security. 
 (iv) If the Company shall solicit from the Holders any
request, demand, authorization, direction, notice, consent, waiver or other Act, the Company may, at its option, by or pursuant to a resolution of the Board of Directors, fix in advance a record date for the determination of Holders entitled to give
such request, demand, authorization, direction, notice, consent, waiver or other Act, but the Company shall have no obligation to do so. If such a record date is fixed, such request, demand, authorization, direction, notice, consent, waiver or other
Act may be given before or after such record date, but only the Holders of record at the Close of Business on such record date shall be deemed to be Holders for the purposes of determining whether Holders of the requisite proportion of outstanding
Securities have authorized or agreed or consented to such request, demand, authorization, direction, notice, consent, waiver or other Act, and for that purpose the outstanding Securities shall be computed as of such record date; provided that
no such authorization, agreement or consent by the Holders on such record date shall be deemed effective unless it shall become effective pursuant to the provisions of this Indenture not later than six months after the record date. 
 ARTICLE 2 
 THE
SECURITIES 
 Section 2.01. Form and Dating. 
 The Securities and the Trustee’s certificate of authentication shall be substantially in the form of Exhibit A, which is a part of this Indenture.
The Securities may have notations, legends or endorsements required by law, stock exchange rule or usage (provided that any such notation, legend or endorsement required by usage is in a form acceptable to the Company). The Company shall
provide any such notations, legends or endorsements to the Trustee in writing. Each Security shall be dated the date of its authentication. The Securities are being offered and sold by the Company pursuant to a Purchase Agreement, dated
April 19, 2006 (the “Purchase Agreement”), by and among the Company and Merrill Lynch, Pierce, Fenner & Smith Incorporated, Morgan Stanley & Co. Incorporated and Banc of America Securities LLC, as 

  

 10 

 
representatives on behalf of the initial purchasers named in Schedule A thereto (collectively, the “Initial Purchasers”), in transactions
exempt from, or not subject to, the registration requirements of the Securities Act. 
 (i) Restricted Global Securities. All of the
Securities are initially being offered and sold to qualified institutional buyers as defined in Rule 144A in reliance on Rule 144A under the Securities Act and shall be issued initially in the form of one or more Restricted Global Securities, which
shall be deposited on behalf of the purchasers of the securities represented thereby with the Trustee, at its Corporate Trust Office, as custodian for the Depositary, and registered in the name of its nominee, Cede & Co. (or any successor
thereto), for the accounts of participants in the Depositary, duly executed by the Company and authenticated by the Trustee as hereinafter provided. 
 (ii) Global Securities in General. Each Global Security shall represent such of the outstanding Securities as shall be specified therein and each shall provide that it shall represent the aggregate Principal
Amount of outstanding Securities from time to time endorsed thereon and that the aggregate Principal Amount of outstanding Securities represented thereby may from time to time be reduced or increased, as appropriate, to reflect exchanges,
redemptions and conversions. Except as provided in this Section 2.01 or Sections 2.06 or 2.12, owners of beneficial interests in Global Securities will not be entitled to receive physical delivery of Certificated Securities. 
 Any adjustment of the aggregate Principal Amount of a Global Security to reflect the amount of any increase or decrease in the Principal Amount of
outstanding Securities represented thereby shall be made by the Trustee in accordance with instructions given by the Holder thereof as required by Section 2.12 hereof and shall be made on the records of the Trustee and the Depositary, subject
in each case to compliance with Applicable Procedures. 
 (iii) Book-Entry Provisions. This Section 2.01(c) shall apply only to
Global Securities deposited with or on behalf of the Depositary. 
 The Company shall execute and the Trustee shall, in accordance with this
Section 2.01(c), authenticate and deliver initially one or more Global Securities that (a) shall be registered in the name of the Depositary, (b) shall be delivered by the Trustee to the Depositary or pursuant to the Depositary’s
instructions and (c) shall bear legends substantially to the following effect: 
 “UNLESS THIS CERTIFICATE IS PRESENTED BY AN
AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY TO THE ISSUER OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED
BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY (AND ANY PAYMENT HEREON IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY), ANY TRANSFER, PLEDGE OR
OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL 

  

 11 

 
SINCE THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN. 
 TRANSFERS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS, IN WHOLE BUT NOT IN PART, TO NOMINEES OF THE DEPOSITORY TRUST COMPANY OR TO A SUCCESSOR THEREOF OR SUCH SUCCESSOR’S NOMINEE AND TRANSFERS OF
PORTIONS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS MADE IN ACCORDANCE WITH THE RESTRICTIONS SET FORTH IN ARTICLE TWO OF THE INDENTURE REFERRED TO ON THE REVERSE HEREOF.” 
 (iv) Certificated Securities. Securities not issued as interests in the Global Securities will be issued in certificated form substantially in the
form of Exhibit A attached hereto. 
 Section 2.02. Execution and Authentication. 
 (i) The Securities shall be executed on behalf of the Company by any Officer. The signature of the Officer on the Securities may be manual or facsimile.

 (ii) Securities bearing the manual or facsimile signatures of an individual who was at the time of the execution of the Securities the
proper Officer of the Company shall bind the Company, notwithstanding that such individual has ceased to hold such office prior to the authentication and delivery of such Securities or did not hold such office at the date of authentication of such
Securities. 
 (iii) No Security shall be entitled to any benefit under this Indenture or be valid or obligatory for any purpose unless there
appears on such Security a certificate of authentication substantially in the form provided for herein duly executed by the Trustee by manual signature of an authorized officer of the Trustee, and such certificate upon any Security shall be
conclusive evidence, and the only evidence, that such Security has been duly authenticated and delivered hereunder. 
 (iv) Subject to the
terms of Section 12.04 and 12.05 hereof, the Trustee shall authenticate and deliver Securities for original issue in an aggregate Principal Amount of up to $650,000,000 (subject to Section 2.07 hereof) upon a Company Order without any
further action by the Company. The aggregate Principal Amount of Securities outstanding at any time may not exceed the amount set forth in the foregoing sentence, except as provided in Section 2.07. 
 (v) The Securities shall be issued only in registered form without coupons and only in denominations of $1,000 of Principal Amount and any integral
multiple thereof. 
 (vi) The Trustee shall have the right to decline to authenticate and deliver any Securities under this Section if the
Trustee, being advised by counsel, determines that such action may not be lawfully taken or if the Trustee in good faith shall determine that such action would expose the Trustee to personal liability to existing Holders. 
  

 12 

 Section 2.03. Registrar, Paying Agent and Conversion Agent. 
 (i) The Company shall maintain an office or agency where Securities may be presented for registration of transfer or for exchange for other Securities
(“Registrar”), an office or agency where Securities may be presented for purchase or payment (“Paying Agent”) and an office or agency where Securities may be presented for conversion into Common Stock
(“Conversion Agent”). The Registrar shall keep a register of the Securities and of their registration of transfer and exchange. The Company may have one or more co-registrars, one or more additional paying agents and one or more
additional conversion agents. The term Paying Agent includes any additional paying agent, including any named pursuant to Section 4.04. The term Conversion Agent includes any additional conversion agent, including any named pursuant to
Section 4.04. 
 (ii) The Company shall enter into an appropriate agency agreement with any Registrar or co-registrar, Paying Agent or
Conversion Agent (other than the Trustee). The agreement shall implement the provisions of this Indenture that relate to such agent. The Company shall notify the Trustee of the name and address of any such agent. If the Company fails to maintain a
Registrar, Paying Agent or Conversion Agent, the Trustee shall act as such and shall be entitled to appropriate compensation therefor pursuant to Section 7.07. The Company or any Subsidiary or an Affiliate of either of them may act as Paying
Agent, Registrar, Conversion Agent or co-registrar. 
 (iii) The Company initially appoints the Trustee as Registrar, Conversion Agent and
Paying Agent in connection with the Securities. 
 Section 2.04. Paying Agent to Hold Money and Securities in Trust.

 Except as otherwise provided herein, by no later than 10:00 a.m., New York City time, on or prior to each due date of payments
in respect of any Security, the Company shall deposit with the Paying Agent a sum of money (in immediately available funds if deposited on the due date) or Common Stock sufficient to make such payments when so becoming due. The Company shall require
each Paying Agent (other than the Trustee) to agree in writing that the Paying Agent shall hold in trust for the benefit of Holders or the Trustee all money and Common Stock held by the Paying Agent for the making of payments in respect of the
Securities and shall notify the Trustee of any default by the Company in making any such payment. At any time during the continuance of any such default, the Paying Agent shall, upon the written request of the Trustee, forthwith pay to the Trustee
all money and Common Stock so held in trust. If the Company or a Subsidiary or an Affiliate of either of them acts as Paying Agent, it shall segregate the money and Common Stock held by it as Paying Agent and hold it as a separate trust fund. The
Company at any time may require a Paying Agent to pay all money and Common Stock held by it to the Trustee and to account for any funds and Common Stock disbursed by it. Upon doing so, the Paying Agent shall have no further liability for the money
or Common Stock. 
 Section 2.05. Securityholder Lists. 
 The Trustee shall preserve in as current a form as is reasonably practicable the most recent list available to it of the names and addresses of Holders.
If the Trustee is not the 

  

 13 

 
Registrar, the Company shall cause to be furnished to the Trustee at least semiannually on June 1 and December 1 a listing of Holders dated within
15 days of the date on which the list is furnished and at such other times as the Trustee may request in writing a list in such form and as of such date as the Trustee may reasonably require of the names and addresses of Holders. 
 Section 2.06. Transfer and Conversion. 
 Subject to Section 2.12 hereof: 
 (i) upon surrender for registration of transfer of any Security,
together with a written instrument of transfer satisfactory to the Registrar duly executed by the Holder or such Holder’s attorney duly authorized in writing, at the office or agency of the Company designated as Registrar or co-registrar
pursuant to Section 2.03, the Company shall execute, and the Trustee upon receipt of a Company Order shall authenticate and deliver, in the name of the designated transferee or transferees, one or more new Securities of any authorized
denomination or denominations, of a like aggregate Principal Amount. The Company shall not charge a service charge for any registration of transfer or exchange, but the Company or the Trustee may require payment of a sum sufficient to pay all taxes,
assessments or other governmental charges that may be imposed in connection with the registration of transfer or exchange of the Securities from the Holder requesting such registration of transfer or exchange. 
 At the option of the Holder, Certificated Securities may be exchanged for other Securities of any authorized denomination or denominations, of a like
aggregate Principal Amount, upon surrender of the Securities to be exchanged, together with a written instrument of transfer satisfactory to the Registrar duly executed by the Holder or such Holder’s attorney duly authorized in writing, at such
office or agency. Whenever any Securities are so surrendered for exchange, the Company shall execute, and the Trustee upon receipt of a Company Order shall authenticate and deliver, the Securities which the Holder making the exchange is entitled to
receive. 
 The Company shall not be required to make, and the Registrar need not register, any Securities in respect of which a Change in
Control Purchase Notice has been given and not withdrawn by the Holder thereof in accordance with the terms of this Indenture (except, in the case of Securities to be purchased in part, the portion thereof not to be purchased). 
 (ii) Notwithstanding any provision to the contrary herein, so long as a Global Security remains outstanding and is held by or on behalf of the
Depositary, transfers of a Global Security, in whole or in part, shall be made only in accordance with Section 2.12 and this Section 2.06(b). Transfers of a Global Security shall be limited to transfers of such Global Security in whole, or
in part, to nominees of the Depositary or to a successor of the Depositary or such successor’s nominee. 
 (iii) Successive
registrations and registrations of transfers and exchanges as aforesaid may be made from time to time as desired, and each such registration shall be noted on the register for the Securities. 
  

 14 

 (iv) Any Registrar appointed pursuant to Section 2.03 hereof shall provide to the Trustee such
information as the Trustee may reasonably require in connection with the delivery by such Registrar of Securities upon registration of transfer or exchange of Securities. 
 (v) No Registrar shall be required to make registrations of transfer or exchange of Securities during any periods designated in the text of the Securities or in this Indenture as periods during which such registration
of transfers and exchanges need not be made. 
 Section 2.07. Replacement Securities. 
 (i) If (A) any mutilated Security is surrendered to the Trustee, or (B) the Company and the Trustee receive evidence to their satisfaction of
the destruction, loss or theft of any Security, and there is delivered to the Company and the Trustee such security or indemnity as may be required by them to save each of them harmless, then, in the absence of notice to the Company or the Trustee
that such Security has been acquired by a protected purchaser within the meaning of Article 8 of the Uniform Commercial Code as in effect from time to time in the State of New York (a “Protected Purchaser”), the Company shall
execute and upon a Company Request the Trustee shall authenticate and deliver, in exchange for any such mutilated Security or in lieu of any such destroyed, lost or stolen Security, a new Security of like tenor and Principal Amount, bearing a number
not contemporaneously outstanding. 
 (ii) In case any such mutilated, destroyed, lost or stolen Security has become or is about to become
due and payable, or is about to be purchased by the Company pursuant to Article 3 hereof, the Company in its discretion may, instead of issuing a new Security, pay or purchase such Security, as the case may be. 
 (iii) Upon the issuance of any new Securities under this Section, the Company may require the payment of a sum sufficient to cover any tax or other
governmental charge that may be imposed in relation thereto and any other expenses (including the fees and expenses of the Trustee) connected therewith. 
 (iv) Every new Security issued pursuant to this Section in lieu of any mutilated, destroyed, lost or stolen Security shall constitute an original additional contractual obligation of the Company, whether or not the
mutilated, destroyed, lost or stolen Security shall be at any time enforceable by anyone, and shall be entitled to all benefits of this Indenture equally and proportionately with any and all other Securities duly issued hereunder. 
 (v) The provisions of this Section are exclusive and shall preclude (to the extent lawful) all other rights and remedies with respect to the replacement
or payment of mutilated, destroyed, lost or stolen Securities. 
 Section 2.08. Outstanding Securities; Determinations of
Holders’ Action. 
 (i) Securities outstanding at any time are all the Securities authenticated by the Trustee except for those
cancelled by it, those paid pursuant to Section 2.07 and delivered to it for cancellation and those described in this Section 2.08 as not outstanding. A Security does not cease to be outstanding because the Company or an Affiliate thereof
holds the Security; 

  

 15 

 
provided, however, that in determining whether the Holders of the requisite Principal Amount of Securities have given or concurred in any request,
demand, authorization, direction, notice, consent or waiver hereunder, Securities owned by the Company or any other obligor upon the Securities or any Affiliate of the Company or such other obligor shall be disregarded and deemed not to be
outstanding, except that, in determining whether the Trustee shall be protected in relying upon any such request, demand, authorization, direction, notice, consent or waiver, only Securities which a Responsible Officer of the Trustee actually knows
to be so owned shall be so disregarded. Subject to the foregoing, only Securities outstanding at the time of such determination shall be considered in any such determination (including, without limitation, determinations pursuant to Articles 6 and
9). 
 (ii) If a Security is replaced pursuant to Section 2.07, the replaced Security ceases to be outstanding unless the Trustee and
the Company receive proof satisfactory to each of them that the replaced Security is held by a Protected Purchaser. 
 (iii) If the Paying
Agent holds, in accordance with this Indenture, on a Change in Control Purchase Date, or on Stated Maturity, money or securities, if permitted hereunder, sufficient to pay Securities payable on that date, then immediately after such Change in
Control Purchase Date or Stated Maturity, as the case may be, such Securities shall cease to be outstanding and interest on such Securities shall cease to accrue whether or not the Security is delivered to the Paying Agent. 
 (iv) If a Security is converted in accordance with Article 10, then from and after the time of conversion on the Conversion Date, such Security shall
cease to be outstanding and interest shall cease to accrue on such Security. 
 Section 2.09. Temporary Securities. 
 (i) Pending the preparation of definitive Securities, the Company may execute, and the Trustee upon receipt of a Company Order shall authenticate and
deliver, temporary Securities which are printed, lithographed, typewritten, mimeographed or otherwise produced, in any authorized denomination, substantially of the tenor of the definitive Securities in lieu of which they are issued and with such
appropriate insertions, omissions, substitutions and other variations as the officers executing such Securities may determine, as conclusively evidenced by their execution of such Securities. 
 (ii) If temporary Securities are issued, the Company will cause definitive Securities to be prepared without unreasonable delay. After the preparation of
definitive Securities, the temporary Securities shall be exchangeable for definitive Securities upon surrender of the temporary Securities at the office or agency of the Company designated for such purpose pursuant to Section 2.03, without
charge to the Holder. Upon surrender for cancellation of any one or more temporary Securities, the Company shall execute and the Trustee upon receipt of a Company Order shall authenticate and deliver in exchange therefor a like Principal Amount of
definitive Securities of authorized denominations. Until so exchanged the temporary Securities shall in all respects be entitled to the same benefits under this Indenture as definitive Securities. 
  

 16 

 Section 2.10. Cancellation. 
 All Securities surrendered for payment, purchased by the Company pursuant to Article 3, conversion or registration of transfer or exchange shall, if
surrendered to any person other than the Trustee, be delivered to the Trustee and shall be promptly cancelled by it. The Company may at any time deliver to the Trustee for cancellation any Securities previously authenticated and delivered hereunder
which the Company may have acquired in any manner whatsoever, and all Securities so delivered shall be promptly cancelled by the Trustee. The Company may not issue new Securities to replace Securities it has paid or delivered to the Trustee for
cancellation or that any Holder has converted pursuant to Article 10. No Securities shall be authenticated in lieu of or in exchange for any Securities cancelled as provided in this Section, except as expressly permitted by this Indenture. All
cancelled Securities held by the Trustee shall be disposed of by the Trustee in accordance with the Trustee’s customary procedure. 
 Section 2.11. Persons Deemed Owners. 
 Prior to due presentment of a Security for registration of transfer, the
Company, the Trustee and any agent of the Company or the Trustee may treat the Person in whose name such Security is registered as the owner of such Security for the purpose of receiving payment of principal of the Security or the payment of any
Change in Control Purchase Price in respect thereof, and interest thereon, for the purpose of conversion and for all other purposes whatsoever, whether or not such Security be overdue, and neither the Company, the Trustee nor any agent of the
Company or the Trustee shall be affected by notice to the contrary. 
 Section 2.12. Legend; Additional Transfer and Exchange
Requirements. 
 (i) If Securities are issued upon the transfer, exchange or replacement of Securities subject to restrictions on
transfer and bearing the legends set forth in Section 2.12(f) (collectively, the “Legend”), or if a request is made to remove the Legend on a Security, the Securities so issued shall bear the Legend, or the Legend shall not be
removed, as the case may be, unless there is delivered to the Company and the Registrar such satisfactory evidence, which shall include an Opinion of Counsel, as may be reasonably required by the Company and the Registrar, that neither the Legend
nor the restrictions on transfer set forth therein are required to ensure that transfers thereof comply with the provisions of Rule 144A or Rule 144 under the Securities Act or that such Securities are not “restricted” within the meaning
of Rule 144 under the Securities Act; provided that no such evidence need be supplied in connection with the sale of such Security pursuant to a registration statement that is effective at the time of such sale. Upon (A) provision of
such satisfactory evidence if requested, or (B) notification by the Company to the Trustee and Registrar of the sale of such Security pursuant to a registration statement that is effective at the time of such sale, the Trustee, upon Company
Order, shall authenticate and deliver a Security that does not bear the Legend. If the Legend is removed from the face of a Security and the Security is subsequently held by an Affiliate of the Company, the Legend shall be reinstated. 
 (ii) Subject to Section 2.12(c)(i) and in compliance with Section 2.12(d), every Security shall be subject to the restrictions on transfer
provided in the Legend. Whenever any Restricted Security other than a Restricted Global Security is presented or surrendered for 

  

 17 

 
registration of transfer or in exchange for a Security registered in a name other than that of the Holder, such Security must be accompanied by a certificate
in substantially the form set forth in Exhibit A, dated the date of such surrender and signed by the Holder of such Security, as to compliance with such restrictions on transfer. The Registrar shall not be required to accept for such registration of
transfer or exchange any Security not so accompanied by a properly completed certificate. 
 (iii) Notwithstanding any other provisions of
this Indenture or the Securities, (A) transfers of a Global Security, in whole or in part, shall be made only in accordance with Section 2.06 and Section 2.12(c)(i), (B) transfer of a beneficial interest in a Global Security for
a Certificated Security shall comply with Section 2.06 and Section 2.12(c)(ii) below, and (C) transfers of a Certificated Security shall comply with Section 2.06 and Section 2.12(c)(iii) and (iv) below. 
 (A) Transfer of Global Security. A Global Security may not be transferred, in whole or in part, to any Person other than the Depositary or
a nominee or any successor thereof, and no such transfer to any such other Person may be registered; provided that this clause (i) shall not prohibit any transfer of a Security that is issued in exchange for a Global Security but is not
itself a Global Security. No transfer of a Security to any Person shall be effective under this Indenture or the Securities unless and until such Security has been registered in the name of such Person. Nothing in this Section 2.12(c)(i) shall
prohibit or render ineffective any transfer of a beneficial interest in a Global Security effected in accordance with the other provisions of this Section 2.12(c). 
 (B) Restrictions on Transfer of a Beneficial Interest in a Global Security for a Certificated Security. A beneficial interest in a Global
Security may not be exchanged for a Certificated Security except upon satisfaction of the requirements set forth below. Upon receipt by the Trustee of a request for transfer of a beneficial interest in a Global Security in accordance with Applicable
Procedures for a Certificated Security in the form satisfactory to the Trustee, together with written instructions to the Trustee to make, or direct the Registrar to make, an adjustment on its books and records with respect to such Global Security
to reflect a decrease in the aggregate Principal Amount of the Securities represented by the Global Security, such instructions to contain information regarding the Depositary account to be credited with such decrease, then the Trustee shall cause,
or direct the Registrar to cause, in accordance with the standing instructions and procedures existing between the Depositary and the Registrar, the aggregate Principal Amount of Securities represented by the Global Security to be decreased by the
aggregate Principal Amount of the Certificated Security to be issued, shall authenticate and deliver such Certificated Security and shall debit or cause to be debited to the account of the Person specified in such instructions a beneficial interest
in the Global Security equal to the Principal Amount of the Certificated Security so issued. 
 (C) Transfer and Exchange of
Certificated Securities. When Certificated Securities are presented to the Registrar with a request: 
 (x) to register the
transfer of such Certificated Securities; or 
  

 18 

 (y) to exchange such Certificated Securities for an equal Principal Amount of
Certificated Securities of other authorized denominations, 
 the Registrar shall register the transfer or make the exchange as requested if
its reasonable requirements for such transaction are met; provided, however, that the Certificated Securities surrendered for registration of transfer or exchange shall be duly endorsed or accompanied by a written instrument of transfer in
form reasonably satisfactory to the Company and the Registrar, duly executed by the Holder thereof or his attorney duly authorized in writing. 
 (D) Restrictions on Transfer of a Certificated Security for a Beneficial Interest in a Global Security. A Certificated Security may not be exchanged for a beneficial interest in a Global Security except upon
satisfaction of the requirements set forth below. 
 Upon receipt by the Trustee of a Certificated Security, duly endorsed or accompanied by
appropriate instruments of transfer, in form satisfactory to the Trustee, together with written instructions directing the Trustee to make, or to direct the Registrar to make, an adjustment on its books and records with respect to such Global
Security to reflect an increase in the aggregate Principal Amount of the Securities represented by the Global Security, such instructions to contain information regarding the Depositary account to be credited with such increase, then the Trustee
shall cancel such Certificated Security and cause, or direct the Registrar to cause, in accordance with the standing instructions and procedures existing between the Depositary and the Registrar, the aggregate Principal Amount of Securities
represented by the Global Security to be increased by the aggregate Principal Amount of the Certificated Security to be exchanged, and shall credit or cause to be credited to the account of the Person specified in such instructions a beneficial
interest in the Global Security equal to the Principal Amount of the Certificated Security so cancelled. If no Global Securities are then outstanding, the Company shall issue and the Trustee upon receipt of a Company Order shall authenticate a new
Global Security in the appropriate Principal Amount. 
 (iv) The restrictions imposed by the Legend upon the transferability of any Security
shall cease and terminate when such Security has been sold pursuant to an effective registration statement under the Securities Act or transferred in compliance with Rule 144 under the Securities Act (or any successor provision thereto) or, if
earlier, upon the expiration of the holding period applicable to sales thereof under Rule 144(k) under the Securities Act (or any successor provision). Any Security as to which such restrictions on transfer shall have expired in accordance with
their terms or shall have terminated may, upon a surrender of such Security for exchange to the Registrar in accordance with the provisions of this Section 2.12 (accompanied, in the event that such restrictions on transfer have terminated by
reason of a transfer in compliance with Rule 144 or any successor provision, by an Opinion of Counsel reasonably acceptable to the Company and the Registrar and addressed to the Company and the Registrar, to the effect that the transfer of such
Security has been made in compliance with Rule 144 or such successor provision), be exchanged for a new Security, of like tenor and aggregate Principal Amount, which shall not bear the restrictive Legend. The Company shall inform the Trustee of the
effective date of any registration statement registering the offer and sale of the Securities 

  

 19 

 
under the Securities Act. The Trustee or the Registrar shall not be liable for any action taken or omitted to be taken by it in good faith in accordance with
the aforementioned Opinion of Counsel. 
 As used in Sections 2.12(b) and (d), the term “transfer” encompasses any sale, pledge,
transfer, hypothecation or other disposition of any Security 
 (v) The provisions of clauses (1), (2), (3) and (4) below shall
apply only to Global Securities: 
 (1) Notwithstanding any other provisions of this Indenture or the Securities, except as
provided in Section 2.12(c)(ii), a Global Security shall not be exchanged in whole or in part for a Security registered in the name of any Person other than the Depositary or one or more nominees thereof, provided that a Global Security
may be exchanged for Securities registered in the names of any person designated by the Depositary in the event that (i) the Depositary has notified the Company that it is unwilling or unable to continue as Depositary for such Global Security
or such Depositary has ceased to be a “clearing agency” registered under the Exchange Act, and a successor Depositary is not appointed by the Company within 90 days, (ii) the Company decides to discontinue use of the system of
book-entry transfer through DTC (or any successor depositary); or (iii) an Event of Default has occurred and is continuing with respect to the Securities. Any Global Security exchanged pursuant to clause (i) or (ii) above shall be so
exchanged in whole and not in part, and any Global Security exchanged pursuant to clause (iii) above may be exchanged in whole or from time to time in part as directed by the Depositary. Any Security issued in exchange for a Global Security or
any portion thereof shall be a Global Security; provided that any such Security so issued that is registered in the name of a Person other than the Depositary or a nominee thereof shall not be a Global Security. 
 (2) Securities issued in exchange for a Global Security or any portion thereof shall be issued in definitive, fully registered form,
without interest coupons, shall have an aggregate Principal Amount equal to that of such Global Security or portion thereof to be so exchanged, shall be registered in such names and be in such authorized denominations as the Depositary shall
designate and shall bear the applicable legends provided for herein. Any Global Security to be exchanged in whole shall be surrendered by the Depositary to the Trustee, as Registrar. With regard to any Global Security to be exchanged in part, either
such Global Security shall be so surrendered for exchange or, if the Trustee is acting as custodian for the Depositary or its nominee with respect to such Global Security, the Principal Amount thereof shall be reduced, by an amount equal to the
portion thereof to be so exchanged, by means of an appropriate adjustment made on the records of the Trustee. Upon any such surrender or adjustment, the Trustee shall authenticate and deliver the Security issuable on such exchange to or upon the
order of the Depositary or an authorized representative thereof. 
 (3) Subject to the provisions of clause (5) below,
the registered Holder may grant proxies and otherwise authorize any Person, including Agent Members (as defined 

  

 20 

 
below) and persons that may hold interests through Agent Members, to take any action which a holder is entitled to take under this Indenture or the
Securities. 
 (4) In the event of the occurrence of any of the events specified in clause (1) above, the Company will
promptly make available to the Trustee a reasonable supply of Certificated Securities in definitive, fully registered form, without interest coupons. 
 (5) Neither any members of, or participants in, the Depositary (collectively, the “Agent Members”) nor any other Persons on whose behalf Agent Members may act shall have any rights under this
Indenture with respect to any Global Security registered in the name of the Depositary or any nominee thereof, or under any such Global Security, and the Depositary or such nominee, as the case may be, may be treated by the Company, the Trustee and
any agent of the Company or the Trustee as the absolute owner and holder of such Global Security for all purposes whatsoever. Notwithstanding the foregoing, nothing herein shall prevent the Company, the Trustee or any agent of the Company or the
Trustee from giving effect to any written certification, proxy or other authorization furnished by the Depositary or such nominee, as the case may be, or impair, as between the Depositary, its Agent Members and any other person on whose behalf an
Agent Member may act, the operation of customary practices of such Persons governing the exercise of the rights of a holder of any Security. 
 (vi) Until the expiration of the holding period applicable to sales thereof under Rule 144(k) under the Securities Act (or any successor provision thereto), any stock certificate representing Common Stock issued upon conversion of any
Security shall bear a legend in substantially the following form, unless such Common Stock has been sold pursuant to a registration statement that has been declared effective under the Securities Act (and which continues to be effective at the time
of such transfer) or transferred in compliance with Rule 144 under the Securities Act (or any successor provision thereto), or such Common Stock has been issued upon conversion of Securities that have been transferred pursuant to a registration
statement that has been declared effective under the Securities Act or pursuant to Rule 144 under the Securities Act (or any successor provision thereto), or unless otherwise agreed by the Company in writing with written notice thereof to the
transfer agent: 
 THE COMMON STOCK EVIDENCED HEREBY HAS NOT BEEN REGISTERED UNDER THE UNITED STATES SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES
ACT”), OR ANY STATE SECURITIES LAWS, AND, ACCORDINGLY, MAY NOT BE REOFFERED, SOLD, ASSIGNED, TRANSFERRED, PLEDGED, ENCUMBERED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF SUCH REGISTRATION OR UNLESS SUCH TRANSACTION IS EXEMPT FROM, OR NOT SUBJECT
TO, REGISTRATION UNDER THE SECURITIES ACT. 
 BY ITS ACQUISITION HEREOF, THE HOLDER AGREES TO OFFER, SELL OR OTHERWISE TRANSFER THE COMMON STOCK EVIDENCED
HEREBY PRIOR TO THE DATE THAT IS TWO YEARS AFTER THE LATER OF THE ORIGINAL ISSUE DATE HEREOF AND THE LAST DATE ON WHICH GILEAD SCIENCES, INC. (THE “COMPANY”) OR ANY AFFILIATE OF THE COMPANY WAS THE OWNER OF THE COMMON STOCK EVIDENCED
HEREBY (OR ANY PREDECESSOR OF THE COMMON 

  

 21 

 
STOCK EVIDENCED HEREBY) (THE “RESALE RESTRICTION TERMINATION DATE”) ONLY (A) TO THE COMPANY OR ANY SUBSIDIARY THEREOF, (B) PURSUANT TO A
REGISTRATION STATEMENT WHICH HAS BEEN DECLARED EFFECTIVE UNDER THE SECURITIES ACT, OR (C) PURSUANT TO ANY OTHER AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT, SUBJECT TO THE COMPANY’S AND THE TRANSFER
AGENT’S RIGHT PRIOR TO ANY SUCH OFFER, SALE OR TRANSFER PURSUANT TO CLAUSE (C) PRIOR TO THE RESALE RESTRICTION TERMINATION DATE TO REQUIRE THE DELIVERY OF AN OPINION OF COUNSEL, CERTIFICATIONS AND/OR OTHER INFORMATION SATISFACTORY TO EACH
OF THEM, AND IN EACH OF THE FOREGOING CASES, TO REQUIRE THAT A CERTIFICATE OF TRANSFER IN THE FORM APPEARING ON THE OTHER SIDE OF THIS CERTIFICATE IS COMPLETED AND DELIVERED BY THE TRANSFEROR TO THE TRANSFER AGENT. THIS LEGEND WILL BE REMOVED UPON
THE REQUEST OF THE HOLDER AFTER THE RESALE RESTRICTION TERMINATION DATE. 
 Any such Common Stock as to which such restrictions on transfer
shall have expired in accordance with their terms or as to which the conditions for removal of the foregoing legend set forth therein have been satisfied may, upon surrender of the certificates representing such shares of Common Stock for exchange
in accordance with the procedures of the transfer agent for the Common Stock, be exchanged for a new certificate or certificates for a like number of shares of Common Stock, which shall not bear the restrictive legend required by this section.

 (vii) Until the expiration of the holding period applicable to sales thereof under Rule 144(k) under the Securities Act (or any successor
provision thereto), any certificate representing any Security shall bear a legend in substantially the following form, unless such Security has been sold pursuant to a registration statement that has been declared effective under the Securities Act
(and which continues to be effective at the time of such transfer) or transferred in compliance with Rule 144 under the Securities Act (or any successor provision thereto), or unless otherwise agreed by the Company in writing with written notice
thereof to the transfer agent: 
 THE NOTES AND THE SHARES OF COMMON STOCK ISSUABLE UPON CONVERSION OF THIS NOTE HAVE NOT BEEN REGISTERED UNDER THE
SECURITIES ACT OF 1933, AS AMENDED (THE SECURITIES ACT), OR ANY STATE SECURITIES LAWS. NEITHER THIS NOTE, THE SHARES OF COMMON STOCK ISSUABLE UPON CONVERSION OF THIS NOTE NOR ANY INTEREST OR PARTICIPATION HEREIN OR THEREIN MAY BE REOFFERED, SOLD,
ASSIGNED, TRANSFERRED, PLEDGED, ENCUMBERED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF SUCH REGISTRATION OR UNLESS SUCH TRANSACTION IS EXEMPT FROM, OR NOT SUBJECT TO, REGISTRATION. 
 BY ITS ACQUISITION HEREOF, THE HOLDER AGREES TO OFFER, SELL OR OTHERWISE TRANSFER SUCH NOTE PRIOR TO THE DATE WHICH IS TWO YEARS AFTER THE LATER OF THE LAST ORIGINAL ISSUE DATE HEREOF AND THE LAST DATE ON WHICH THE
COMPANY OR ANY AFFILIATE OF THE COMPANY WAS THE OWNER OF THIS NOTE (OR ANY PREDECESSOR OF THIS NOTE) ONLY (A) TO THE COMPANY OR ANY SUBSIDIARY THEREOF, (B) PURSUANT TO A REGISTRATION 

  

 22 

 
STATEMENT WHICH HAS BEEN DECLARED EFFECTIVE UNDER THE SECURITIES ACT, (C) TO A PERSON IT REASONABLY BELIEVES IS A QUALIFIED INSTITUTIONAL BUYER AS
DEFINED IN RULE 144A THAT PURCHASES FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT OF A QUALIFIED INSTITUTIONAL BUYER TO WHOM NOTICE IS GIVEN THAT THE TRANSFER IS BEING MADE IN RELIANCE ON RULE 144A, (D) PURSUANT TO ANOTHER AVAILABLE EXEMPTION FROM THE
REGISTRATION REQUIREMENTS OF THE SECURITIES ACT, SUBJECT TO THE COMPANY’S AND THE TRUSTEE’S RIGHT PRIOR TO ANY SUCH OFFER, SALE OR TRANSFER PURSUANT TO CLAUSE (D) TO REQUIRE THE DELIVERY OF AN OPINION OF COUNSEL, CERTIFICATIONS AND/OR
OTHER INFORMATION SATISFACTORY TO EACH OF THEM, AND IN EACH OF THE FOREGOING CASES, TO REQUIRE THAT A CERTIFICATE OF TRANSFER IN THE FORM APPEARING ON THE OTHER SIDE OF THIS NOTE IS COMPLETED AND DELIVERED BY THE TRANSFEROR TO THE TRUSTEE. THIS
LEGEND WILL BE REMOVED UPON THE REQUEST OF THE HOLDER AFTER THE RESALE RESTRICTION TERMINATION DATE. 
 Any such Security as to which such
restrictions on transfer shall have expired in accordance with their terms or as to which the conditions for removal of the foregoing legend set forth therein have been satisfied may, upon surrender of the certificates representing such Security for
exchange in accordance with the procedures of the transfer agent, be exchanged for a new certificate or certificates for a like amount of Securities, which shall not bear the restrictive legend required by this section. 
 Section 2.13. CUSIP Numbers. 
 The Company in issuing the Securities may use “CUSIP” numbers (if then generally in use), and, if so, the Trustee shall use “CUSIP” numbers in notices of redemption as a convenience to Holders; provided that any
such notice may state that no representation is made as to the correctness of such numbers either as printed on the Securities or as contained in any notice of a redemption and that reliance may be placed only on the other identification numbers
printed on the Securities, and any such redemption shall not be affected by any defect in or omission of such numbers. The Company will promptly notify the Trustee in writing of any change in the CUSIP numbers. 
 ARTICLE 3 
 PURCHASES

 Section 3.01. Purchase of Securities at Option of the Holder Upon Change in Control. 
 (i) If prior to the Stated Maturity, there shall have occurred a Change in Control, each Holder shall have the right, at such Holder’s option, to
require the Company to purchase for cash all or any portion of such Holder’s Securities in integral multiples of $1,000 Principal Amount at a purchase price specified in paragraph 5 of the Securities (the “Change in Control Purchase
Price”), as of the date that is no later than 35 Business Days after the occurrence of the Change in Control but in no event prior to the date on which such Change in Control occurs (the 

  

 23 

 
“Change in Control Purchase Date”), subject to satisfaction by or on behalf of the Holder of the requirements set forth in
Section 3.01(c). 
 (ii) As promptly as practicable following the date the Company publicly announces the Change in Control transaction,
but in no event less than 15 Business Days prior to the anticipated effective date of a Change in Control, the Company shall mail a written notice of Change in Control by first-class mail to the Trustee and to each Holder at their addresses shown in
the register of the Registrar (and to beneficial owners as required by applicable law). The notice shall include a form of Change in Control Purchase Notice to be completed by the Holder and shall state: 
 (1) briefly, the events causing a Change in Control; 
 (2) the anticipated effective date of such Change in Control; 
 (3) the date by which the Change in Control Purchase Notice pursuant to this Section 3.01 must be given; 
 (4) the Change in Control Purchase Price; 
 (5) the Change in Control Purchase Date; 
 (6) the name and address of the Paying Agent and
the Conversion Agent; 
 (7) the Conversion Rate and any adjustments thereto; 
 (8) that Securities with respect to which a Change in Control Purchase Notice has been given by the Holder may be converted pursuant to
Article 10 hereof only if the Change in Control Purchase Notice has been withdrawn in accordance with the terms of this Indenture; 
 (9) the procedures a Holder must follow to exercise rights under this Section 3.01; 
 (10) that Securities must
be surrendered to the Paying Agent to collect payment of the Change in Control Purchase Price; 
 (11) that the Change in
Control Purchase Price for any Security as to which a Change in Control Purchase Notice has been duly given and not withdrawn, together with any accrued interest payable with respect thereto, will be paid on or prior to the third Business Day
following the later of the Change in Control Purchase Date and the time of surrender of such Security; 
 (12) briefly, the
conversion rights of the Securities; 
 (13) the procedures for withdrawing a Change in Control Purchase Notice; 

 

 24 

 (14) that, unless the Company defaults in making payment of such Change in Control
Purchase Price and interest due, if any, interest on Securities surrendered for purchase will cease to accrue on and after the Change in Control Purchase Date; and 
 (15) the CUSIP number of the Securities. 
 (iii) A Holder may exercise its rights specified in Section 3.01(a) by delivery of a written notice of purchase (a “Change in Control Purchase Notice”) to the Paying Agent at any time prior to
the Close of Business on the Change in Control Purchase Date, stating: 
 (1) if certificated Securities have been issued, the
certificate number of the Securities (or, if the Holder’s Securities are not certificated, the Holder’s notice must comply with appropriate DTC procedures); 
 (2) the portion of the Principal Amount of the Security which the Holder will deliver to be purchased, which portion must be $1,000 or an
integral multiple thereof; and 
 (3) that such Security shall be purchased pursuant to the terms and conditions specified in
paragraph 5 of the Securities. 
 The delivery of such Security to the Paying Agent prior to, on or after the Change in Control Purchase Date
(together with all necessary endorsements) at the offices of the Paying Agent shall be a condition to the receipt by the Holder of the Change in Control Purchase Price therefor; provided, however, that such Change in Control Purchase Price
shall be so paid pursuant to this Section 3.01 only if the Security so delivered to the Paying Agent shall conform in all respects to the description thereof set forth in the related Change in Control Purchase Notice. 
 The Company shall purchase from the Holder thereof, pursuant to this Section 3.01, a portion of a Security if the Principal Amount of such portion
is $1,000 or an integral multiple of $1,000. Provisions of this Indenture that apply to the purchase of all of a Security also apply to the purchase of such portion of such Security. 
 Any purchase by the Company contemplated pursuant to the provisions of this Section 3.01 shall be consummated by the delivery of the consideration
to be received by the Holder (together with accrued and unpaid interest) on or prior to the third Business Day following the later of the Change in Control Purchase Date and the time of delivery of the Security to the Paying Agent in accordance with
this Section 3.01. 
 Notwithstanding anything herein to the contrary, any Holder delivering to the Paying Agent the Change in Control
Purchase Notice contemplated by this Section 3.01(c) shall have the right to withdraw such Change in Control Purchase Notice at any time prior to the Close of Business on the Change in Control Purchase Date by delivery of a written notice of
withdrawal to the Paying Agent in accordance with Section 3.02. 
 The Paying Agent shall promptly notify the Company of the receipt by
it of any Change in Control Purchase Notice or written withdrawal thereof. 
  

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 The Company shall not be required to comply with this Section 3.01 if a third party mails a written
notice of Change in Control in the manner, at the times and otherwise in compliance with this Section 3.01 and repurchases all Securities for which a Change in Control Purchase Notice shall be delivered and not withdrawn. 
 Section 3.02. Effect of Change in Control Purchase Notice. 
 Upon receipt by the Paying Agent of the Change in Control Purchase Notice specified in Section 3.01(c), the Holder of the Security in respect of which such Change in Control Purchase Notice was given shall
(unless such Change in Control Purchase Notice is withdrawn as specified in the following two paragraphs) thereafter be entitled to receive solely the Change in Control Purchase Price and any accrued and unpaid interest, with respect to such
Security. Such Change in Control Purchase Price and interest shall be paid to such Holder, subject to receipt of funds by the Paying Agent, on or prior to the third Business Day following the later of (x) the Change in Control Purchase Date,
with respect to such Security (provided the conditions in Section 3.01(c) have been satisfied) and (y) the time of delivery of such Security to the Paying Agent by the Holder thereof in the manner required by Section 3.01(c).
Securities in respect of which a Change in Control Purchase Notice has been given by the Holder thereof may not be converted pursuant to Article 10 hereof on or after the date of the delivery of such Change in Control Purchase Notice unless such
Change in Control Purchase Notice has first been validly withdrawn as specified in the following two paragraphs. 
 A Change in Control
Purchase Notice may be withdrawn by means of a written notice of withdrawal delivered to the office of the Paying Agent in accordance with the Change in Control Purchase Notice at any time prior to the Close of Business on the Change in Control
Purchase Date specifying: 
 (1) the certificate numbers of the Securities being withdrawn (or, if the Holder’s
Securities are not certificated, the Holder’s notice must comply with appropriate DTC procedures), 
 (2) the Principal
Amount of the Security with respect to which such notice of withdrawal is being submitted, and 
 (3) the Principal Amount, if
any, of such Security which remains subject to the original Change in Control Purchase Notice and which has been or will be delivered for purchase by the Company. 
 A written notice of withdrawal of a Change in Control Purchase Notice may be in the form set forth in the preceding paragraph. 
 There shall be no purchase of any Securities pursuant to 3.01 if there has occurred (prior to, on or after, as the case may be, the giving, by the Holders of such Securities, of the required Change in Control Purchase
Notice) and is continuing an Event of Default (other than a default in the payment of the Change in Control Purchase Price). The Paying Agent will promptly return to the respective Holders thereof any Securities (x) with respect to which a
Change in Control Purchase Notice has been withdrawn in compliance with this Indenture, or (y) held by it 

  

 26 

 
during the continuance of an Event of Default (other than a default in the payment of the Change in Control Purchase Price) in which case, upon such return,
the Change in Control Purchase Notice with respect thereto shall be deemed to have been withdrawn. 
 Section 3.03. Deposit of Change in
Control Purchase Price. 
 Prior to 10:00 a.m. (New York City time) on or prior to the third Business Day following the Change in Control
Purchase Date, as the case may be, the Company shall deposit with the Trustee or with the Paying Agent (or, if the Company or a Subsidiary or an Affiliate of either of them is acting as the Paying Agent, shall segregate and hold in trust as provided
in Section 2.04) an amount of money (in immediately available funds if deposited on such Business Day) sufficient to pay the aggregate Change in Control Purchase Price of all the Securities or portions thereof which are to be purchased as of
the Change in Control Purchase Date. 
 Section 3.04. Securities Purchased in Part. 
 Any Security which is to be purchased only in part shall be surrendered at the office of the Paying Agent (with, if the Company or the Trustee so
requires, due endorsement by, or a written instrument of transfer in form satisfactory to the Company and the Trustee duly executed by, the Holder thereof or such Holder’s attorney duly authorized in writing) and the Company shall execute and
the Trustee shall authenticate and deliver to the Holder of such Security, without service charge, a new Security or Securities, of any authorized denomination as requested by such Holder in aggregate Principal Amount equal to, and in exchange for,
the portion of the Principal Amount of the Security so surrendered which is not purchased. 
 Section 3.05. Covenant to Comply With
Securities Laws Upon Purchase of Securities. 
 In connection with any offer to purchase or purchase of Securities under
Section 3.01 hereof (provided that such offer or purchase constitutes an “issuer tender offer” for purposes of Rule 13e-4 (which term, as used herein, includes any successor provision thereto) under the Exchange Act at the time
of such offer or purchase), the Company shall, to the extent required by law, (i) comply with Rule 13e-4, Rule 14e-1 and any other tender offer rules under the Exchange Act which may then apply and (ii) otherwise comply with all Federal
and state securities laws so as to permit the rights and obligations under 3.01 to be exercised in the time and in the manner specified in Section 3.01. 
 Section 3.06. Repayment to the Company. 
 The Trustee and the Paying Agent shall return to the
Company any cash that remains unclaimed as provided in paragraph 10 of the Securities, together with interest thereon (subject to the provisions of Section 7.01(f)), held by them for the payment of the Change in Control Purchase Price;
provided, however, that to the extent that the aggregate amount of cash deposited by the Company pursuant to Section 3.03 exceeds the aggregate Change in Control Purchase Price, with respect to, the Securities or portions thereof which
the Company is obligated to purchase as of the Change in Control Purchase Date, whether as a result of withdrawal or otherwise, then promptly after the Business Day following the Change in Control Purchase Date, 

  

 27 

 
the Trustee shall return any such excess to the Company together with interest thereon, if any (subject to the provisions of Section 7.01(f)).

 ARTICLE 4 
 COVENANTS 
 Section 4.01. Payment of Securities. 
 The Company shall promptly make all payments of principal of, premium, if any, and interest in respect of the Securities on the dates and in the manner
provided in the Securities or pursuant to this Indenture. Any amounts to be given to the Trustee or Paying Agent, shall be deposited with the Trustee or Paying Agent by 10:00 a.m., New York City time, by the Company. Principal Amount, Change in
Control Purchase Price, and interest, shall be considered paid on the applicable date due if on such date (or, in the case of a Change in Control Purchase Price, on or prior to the third Business Day following the applicable Change in Control
Purchase Date) the Trustee or the Paying Agent holds, in accordance with this Indenture, money or securities, if permitted hereunder, sufficient to pay all such amounts then due. All references in this indenture to “interest” shall include
Additional Interest, if any. The Company shall pay all Additional Interest, if any, in the same manner on the dates set forth in the Securities and in the amounts set forth in the Registration Rights Agreement. 
 The Company shall, to the extent permitted by law, pay interest on overdue amounts at the rate per annum set forth in paragraph 1 of the Securities,
compounded semiannually, which interest shall accrue from the date such overdue amount was originally due to the date payment of such amount, including interest thereon, has been made or duly provided for. 
 Section 4.02. SEC and Other Reports. 
 The Company shall deliver to the Trustee, within 15 days after it files such annual and quarterly reports, information, documents and other reports with the SEC, copies of its annual report and of the information, documents and other
reports (or copies of such portions of any of the foregoing as the SEC may by rules and regulations prescribe) which the Company is required to file with the SEC pursuant to Section 13 or 15(d) of the Exchange Act. In the event the Company is
at any time no longer subject to the reporting requirements of Section 13 or 15(d) of the Exchange Act, it shall continue to provide the Trustee with reports containing substantially the same information as would have been required to be filed
with the SEC had the Company continued to have been subject to such reporting requirements. In such event, such reports shall be provided at the times the Company would have been required to provide reports had it continued to have been subject to
such reporting requirements. The Company also shall comply with the other provisions of TIA Section 314(a). Delivery of such reports, information and documents to the Trustee is for informational purposes only and the Trustee’s receipt of
the same shall not constitute constructive notice of any information contained therein or determinable from information contained therein, including the Company’s compliance with any of its covenants hereunder (as to which the Trustee is
entitled to rely exclusively on Officers’ Certificates). 
  

 28 

 Section 4.03. Compliance Certificate. 
 The Company shall deliver to the Trustee within 120 days after the end of each fiscal year of the Company (beginning with the fiscal year ending on
December 31, 2006) an Officers’ Certificate, stating whether or not to the knowledge of the signers thereof the Company is in default in the performance and observance of any of the terms, provisions and conditions of this Indenture
(without regard to any period of grace or requirement of notice provided hereunder) and if the Company shall be in default, specifying all such defaults and the nature and status thereof of which they may have knowledge. 
 Section 4.04. Maintenance of Office or Agency. 
 The Company will maintain an office or agency of the Trustee, Registrar, Paying Agent and Conversion Agent where Securities may be presented or surrendered for payment, where Securities may be surrendered for
registration of transfer, exchange for other Securities, purchase or conversion for Common Stock and where notices and demands to or upon the Company in respect of the Securities and this Indenture may be served. The Trustee’s office specified
in Section 12.02 shall initially be such office or agency for all of the aforesaid purposes. The Company shall give prompt written notice to the Trustee of the location, and of any change in the location, of any such office or agency (other
than a change in the location of the office of the Trustee). If at any time the Company shall fail to maintain any such required office or agency or shall fail to furnish the Trustee with the address thereof, such presentations, surrenders, notices
and demands may be made or served at the address of the Trustee set forth in Section 12.02. 
 The Company may also from time to time
designate one or more other offices or agencies where the Securities may be presented or surrendered for any or all such purposes and may from time to time rescind such designations. 
 ARTICLE 5 
 SUCCESSOR CORPORATION 
 Section 5.01. When Company May Merge or Transfer Assets. 
 The Company shall not consolidate with or merge with or into any other person or convey, transfer or lease all or substantially all its properties and assets to another person, unless: 
 (i) either (1) the Company shall be the continuing corporation or (2) the person (if other than the Company) formed by such consolidation or
into which the Company is merged or the person which acquires by conveyance, transfer or lease all or substantially all the properties and assets of the Company (A) shall be organized and validly existing under the laws of the United States,
any State thereof or the District of Columbia and (B) shall expressly assume, by an indenture supplemental hereto, executed and delivered to the Trustee, in form satisfactory to the Trustee, all of the obligations of the Company under the
Securities and this Indenture; 
 (ii) immediately after giving effect to such transaction, no Default shall have occurred and be continuing;
and 
  

 29 

 (iii) the Company shall have delivered to the Trustee an Officers’ Certificate and an Opinion of
Counsel, each stating that such consolidation, merger, conveyance, transfer or lease and, if a supplemental indenture is required in connection with such transaction, such supplemental indenture, comply with this Article 5 and that all conditions
precedent herein provided for relating to such transaction have been satisfied. 
 For purposes of the foregoing, the transfer (by lease,
assignment, sale or otherwise) of the properties and assets of one or more Subsidiaries (other than to the Company or another Subsidiary), which, if such assets were owned by the Company, would constitute all or substantially all of the properties
and assets of the Company, shall be deemed to be the transfer of all or substantially all of the properties and assets of the Company. 
 The
successor person formed by such consolidation or into which the Company is merged or the successor person to which such conveyance, transfer or lease is made shall succeed to, and be substituted for, and may exercise every right and power of, the
Company under this Indenture with the same effect as if such successor had been named as the Company herein; and thereafter, except in the case of a lease and obligations the Company may have under a supplemental indenture pursuant to
Section 10.16, the Company shall be discharged from all obligations and covenants under this Indenture and the Securities. Subject to Section 9.06, the Company, the Trustee and the successor person shall enter into a supplemental indenture
to evidence the succession and substitution of such successor person and such discharge and release of the Company. 
 ARTICLE 6 

DEFAULTS AND REMEDIES 
 Section 6.01. Events of Default. 
 An “Event of Default” occurs if: 
 (1) the Company defaults in the payment of the Principal Amount or Change in Control Purchase Price on any Security when the same becomes
due and payable at its Stated Maturity, upon declaration, when due for purchase by the Company or otherwise; 
 (2) the
Company defaults in payment of any interest due on the Securities, which default continues for 30 days; 
 (3) the Company
fails to comply with any of its agreements in the Securities or this Indenture (other than those referred to in clauses (1) and (2) above) and such failure continues for 60 days after receipt by the Company of a Notice of Default (as
defined below); 
 (4) (a) the Company fails to make any payment by the end of any applicable grace period after maturity
of Indebtedness in an amount in excess of $100,000,000 and continuance of such failure, or (b) the acceleration of Indebtedness has occurred in an amount in excess of $100,000,000 because of a default with respect to such Indebtedness without
such Indebtedness having been discharged or such acceleration having been 

  

 30 

 
cured, waived, rescinded or annulled, in the case of (a) above, for a period of 30 days after receipt by the Company of a Notice of Default;
provided, however, that if any such failure or acceleration referred to in (a) or (b) above shall cease or be cured, waived, rescinded or annulled, then the Event of Default by reason thereof shall be deemed not to have occurred; or

 (5) the Company or any Significant Subsidiary, pursuant to or under or within the meaning of any Bankruptcy Law:

 (A) commences a voluntary case or proceeding; 
 (B) consents to the entry of an order for relief against it in an involuntary case or proceeding or the commencement of any case against
it; 
 (C) consents to the appointment of a Custodian of it or for any substantial part of its property; 
 (D) makes a general assignment for the benefit of its creditors; 
 (E) files a petition in bankruptcy or answer or consent seeking reorganization or relief; or 
 (F) consents to the filing of such petition or the appointment of or taking possession by a Custodian; or 
 (6) a court of competent jurisdiction enters an order or decree under any Bankruptcy Law that: 
 (A) is for relief against the Company or any Significant Subsidiary in an involuntary case or proceeding, or adjudicates the Company or
any Significant Subsidiary insolvent or bankrupt; or 
 (B) appoints a Custodian of the Company or any Significant Subsidiary
or for any substantial part of its property; or 
 (C) orders the winding up or liquidation of the Company or any Significant
Subsidiary; 
 and the order or decree remains unstayed and in effect for 60 days. 
 A Default under clause (3) or clause (4) above is not an Event of Default until the Trustee notifies the Company, or the Holders of at least
25% in aggregate Principal Amount of the Securities at the time outstanding notify the Company and the Trustee, of the Default and the Company does not cure such Default (and such Default is not waived) within the time specified in clause
(3) or clause (4) above after actual receipt of such notice. Any such notice must specify the Default, demand that it be remedied and state that such notice is a “Notice of Default”. 
 The Company shall deliver to the Trustee, within 30 days after it becomes aware of the occurrence thereof, written notice of any event which with the
giving of notice or the lapse of 

  

 31 

 
time, or both, would become an Event of Default under clause (3) or clause (4) above, its status and what action the Company is taking or proposes
to take with respect thereto. 
 Section 6.02. Acceleration. 
 If an Event of Default (other than an Event of Default specified in Section 6.01(5) or (6) in respect of the Company) occurs and is continuing,
the Trustee by Notice to the Company, or the Holders of at least 25% in aggregate Principal Amount of the Securities at the time outstanding by notice to the Company and the Trustee, may declare the Principal Amount through the date of declaration,
and any accrued and unpaid interest through the date of such declaration, on all the Securities to be immediately due and payable. Upon such a declaration, such Principal Amount, and such accrued and unpaid interest if any, shall be due and payable
immediately. If an Event of Default specified in Section 6.01(5) or (6) in respect of the Company occurs and is continuing, the Principal Amount plus accrued and unpaid interest if any, on all the Securities shall become and be immediately
due and payable without any declaration or other act on the part of the Trustee or any Holders. The Holders of a majority in aggregate Principal Amount of the Securities at the time outstanding, by notice to the Trustee (and without notice to any
other Holder) may rescind an acceleration and its consequences if the rescission would not conflict with any judgment or decree and if all existing Events of Default have been cured or waived except nonpayment of the Principal Amount that have
become due solely as a result of acceleration and if all amounts due to the Trustee under Section 7.07 have been paid. No such rescission shall affect any subsequent Default or impair any right consequent thereto. 
 Section 6.03. Other Remedies. 
 If an
Event of Default occurs and is continuing, the Trustee may pursue any available remedy to collect the payment of the Principal Amount plus any accrued and unpaid interest if any, on the Securities or to enforce the performance of any provision of
the Securities or this Indenture. The Trustee may maintain a proceeding even if the Trustee does not possess any of the Securities or does not produce any of the Securities in the proceeding. A delay or omission by the Trustee or any Holder in
exercising any right or remedy accruing upon an Event of Default shall not impair the right or remedy or constitute a waiver of, or acquiescence in, the Event of Default. Except as set forth in Section 2.07 hereof, no remedy is exclusive of any
other remedy. All available remedies are cumulative. 
 Section 6.04. Waiver of Past Defaults. 
 Subject to Section 6.02, the Holders of a majority in aggregate Principal Amount of the Securities at the time outstanding, by notice to the Trustee
(and without notice to any other Holder), may waive an existing or past Default and its consequences except (1) an uncured Event of Default described in Section 6.01(1) or (2), or (2) a Default in respect of a provision that under
Section 9.02 cannot be amended without the consent of each Holder affected. When a Default is waived, it is deemed cured, but no such waiver shall extend to any subsequent or other Default or impair any consequent right. This Section 6.04
shall be in lieu of Section 316(a)1(A) of the TIA and such Section 316(a)1(A) is hereby expressly excluded from this Indenture, as permitted by the TIA. 
  

 32 

 Section 6.05. Control by Majority. 
 The Holders of a majority in aggregate Principal Amount of the Securities at the time outstanding may direct the time, method and place of conducting any
proceeding for any remedy available to the Trustee or of exercising any trust or power conferred on the Trustee. However, the Trustee may refuse to follow any direction that conflicts with law or this Indenture or that the Trustee determines in good
faith is unduly prejudicial to the rights of other Holders or could, in reasonable likelihood, impose personal liability upon the Trustee unless the Trustee is offered indemnity satisfactory to it. This Section 6.05 shall be in lieu of
Section 316(a)1(B) of the TIA and such Section 316(a)1(B) is hereby expressly excluded from this Indenture, as permitted by the TIA. 
 Section 6.06. Limitation on Suits. 
 A Holder may not pursue any remedy with respect to this Indenture or the Securities
unless: 
 (1) the Holder gives to the Trustee written notice stating that an Event of Default is continuing; 
 (2) the Holders of at least 25% in aggregate Principal Amount of the Securities at the time outstanding make a written request to the
Trustee to pursue the remedy; 
 (3) such Holder or Holders offer to the Trustee security or indemnity satisfactory to the
Trustee against any loss, liability or expense; 
 (4) the Trustee does not comply with the request within 60 days after
receipt of such notice, request and offer of security or indemnity; and 
 (5) the Holders of a majority in aggregate
Principal Amount of the Securities at the time outstanding do not give the Trustee a direction inconsistent with the request during such 60-day period. 
 A Holder may not use this Indenture to prejudice the rights of any other Holder or to obtain a preference or priority over any other Holder. 
 Section 6.07. Rights of Holders to Receive Payment. 
 Notwithstanding any other provision of this Indenture, the right of any Holder to receive payment of the Principal Amount, Change in Control Purchase Price, and interest in respect of the Securities held by such
Holder, on or after the respective due dates expressed in the Securities, and to convert the Securities in accordance with Article 10, or to bring suit for the enforcement of any such payment on or after such respective dates or the right to
convert, shall not be impaired or affected adversely without the consent of such Holder. 
  

 33 

 Section 6.08. Collection Suit by Trustee. 
 If an Event of Default described in Section 6.01(1) or (2) occurs and is continuing, the Trustee may recover judgment in its own name and as
trustee of an express trust against the Company for the whole amount owing with respect to the Securities and the amounts provided for in Section 7.07. 
 Section 6.09. Trustee May File Proofs of Claim. 
 In case of the pendency of any receivership,
insolvency, liquidation, bankruptcy, reorganization, arrangement, adjustment, composition or other judicial proceeding relative to the Company or any other obligor upon the Securities or the property of the Company or of such other obligor or their
creditors, the Trustee (irrespective of whether the Principal Amount, Change in Control Purchase Price, and interest in respect of the Securities shall then be due and payable as therein expressed or by declaration or otherwise and irrespective of
whether the Trustee shall have made any demand on the Company for the payment of any such amount) shall be entitled and empowered, by intervention in such proceeding or otherwise, 
 (i) to file and prove a claim for the whole amount of the Principal Amount, Change in Control Purchase Price, or interest and to file such other papers
or documents as may be necessary or advisable in order to have the claims of the Trustee (including any claim for the reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and counsel or any other amounts due the
Trustee under Section 7.07) and of the Holders allowed in such judicial proceeding, and 
 (ii) to collect and receive any moneys or
other property payable or deliverable on any such claims and to distribute the same; 
 and any custodian, receiver, assignee, trustee,
liquidator, sequestrator or similar official in any such judicial proceeding is hereby authorized by each Holder to make such payments to the Trustee and, in the event that the Trustee shall consent to the making of such payments directly to the
Holders, to pay the Trustee any amount due it for the reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and counsel, and any other amounts due the Trustee under Section 7.07. 
 Nothing herein contained shall be deemed to authorize the Trustee to authorize or consent to or accept or adopt on behalf of any Holder any plan of
reorganization, arrangement, adjustment or composition affecting the Securities or the rights of any Holder thereof, or to authorize the Trustee to vote in respect of the claim of any Holder in any such proceeding. 
 Section 6.10. Priorities. 
 If the
Trustee collects any money pursuant to this Article 6, it shall pay out the money in the following order: 
 FIRST: to the Trustee for amounts
due under Section 7.07; 
  

 34 

 SECOND: to Holders for amounts due and unpaid on the Securities for the Principal Amount, Change in
Control Purchase Price and interest, ratably, without preference or priority of any kind, according to such amounts due and payable on the Securities; and 
 THIRD: the balance, if any, to the Company. 
 The Trustee may fix a record date and payment date for any
payment to Holders pursuant to this Section 6.10. At least 15 days before such record date, the Trustee shall mail to each Holder and the Company a notice that states the record date, the payment date and the amount to be paid. 
 Section 6.11. Undertaking for Costs. 
 In any suit for the enforcement of any right or remedy under this Indenture or in any suit against the Trustee for any action taken or omitted by it as Trustee, a court in its discretion may require the filing by any party litigant in the
suit (other than the Trustee) of an undertaking to pay the costs of the suit, and the court in its discretion may assess reasonable costs, including reasonable attorneys’ fees and expenses, against any party litigant in the suit (other than the
Trustee), having due regard to the merits and good faith of the claims or defenses made by the party litigant. This Section 6.11 does not apply to a suit by the Trustee, a suit by a Holder pursuant to Section 6.07 or a suit by Holders of
more than 10% in aggregate Principal Amount of the Securities at the time outstanding. This Section 6.11 shall be in lieu of Section 315(e) of the TIA and such Section 315(e) is hereby expressly excluded from this Indenture, as
permitted by the TIA. 
 Section 6.12. Waiver of Stay, Extension or Usury Laws. 
 The Company covenants (to the extent that it may lawfully do so) that it will not at any time insist upon, or plead, or in any manner whatsoever claim or
take the benefit or advantage of, any stay or extension law or any usury or other law wherever enacted, now or at any time hereafter in force, which would prohibit or forgive the Company from paying all or any portion of the Principal Amount, Change
in Control Purchase Price and interest in respect of Securities, or any interest on such amounts, as contemplated herein, or which may affect the covenants or the performance of this Indenture; and the Company (to the extent that it may lawfully do
so) hereby expressly waives all benefit or advantage of any such law, and covenants that it will not hinder, delay or impede the execution of any power herein granted to the Trustee, but will suffer and permit the execution of every such power as
though no such law had been enacted. 
 ARTICLE 7 
 TRUSTEE 
 Section 7.01. Duties of Trustee. 
 (i) If an Event of Default has occurred and is continuing, the Trustee shall exercise the rights and powers vested in it by this Indenture and use the
same degree of care and skill in its 

  

 35 

 
exercise as a prudent person would exercise or use under the circumstances in the conduct of such person’s own affairs. 
 (ii) Except during the continuance of an Event of Default: 
 (1) the Trustee need perform only those duties that are specifically set forth in this Indenture and no others; and 
 (2) in the absence of bad faith on its part, the Trustee may conclusively rely, as to the truth of the statements and the correctness of the opinions expressed therein, upon any certificate or opinion furnished to the
Trustee and conforming to the requirements of this Indenture, but in case of any such certificates or opinions which by any provision hereof are specifically required to be furnished to the Trustee, the Trustee shall examine the certificates and
opinions to determine whether or not they conform to the requirements of this Indenture, but need not confirm or investigate the accuracy of mathematical calculations or other facts stated therein. 
 This Section 7.01(b) shall be in lieu of Section 315(a) of the TIA and such Section 315(a) is hereby expressly excluded from this
Indenture, as permitted by the TIA. 
 (iii) The Trustee may not be relieved from liability for its own negligent action, its own negligent
failure to act or its own willful misconduct, except that: 
 (1) this paragraph (c) does not limit the effect of
paragraph (b) of this Section 7.01; 
 (2) the Trustee shall not be liable for any error of judgment made in good
faith by a Responsible Officer unless it is proved that the Trustee was negligent in ascertaining the pertinent facts; and 
 (3) the Trustee shall not be liable with respect to any action it takes or omits to take in good faith in accordance with a direction received by it pursuant to Section 6.05. 
 Subparagraphs (c)(1), (2) and (3) shall be in lieu of Sections 315(d)(1), 315(d)(2) and 315(d)(3) of the TIA and such Sections 315(d)(1),
315(d)(2) and 315(d)(3) are hereby expressly excluded from this Indenture, as permitted by the TIA. 
 (iv) Every provision of this Indenture
that in any way relates to the Trustee is subject to paragraphs (a), (b), (c) and (e) of this Section 7.01. 
 (v) The Trustee
may refuse to perform any duty or exercise any right or power or extend or risk its own funds or otherwise incur any financial liability unless it receives indemnity satisfactory to it against any loss, liability or expense. 
 (vi) Money held by the Trustee in trust hereunder need not be segregated from other funds except to the extent required by law. The Trustee (acting in
any capacity hereunder) shall 

  

 36 

 
be under no liability for interest on any money received by it hereunder unless otherwise agreed in writing with the Company. 
 Section 7.02. Rights of Trustee. 
 Subject to its duties and responsibilities under the provisions of Section 7.01, and, except as expressly excluded from this Indenture pursuant to Section 7.01, subject also to its duties and responsibilities under the TIA:

 (i) the Trustee may conclusively rely and shall be protected in acting or refraining from acting upon any resolution, certificate,
statement, instrument, opinion, report, notice, request, direction, consent, order, bond, debenture, note, other evidence of indebtedness or other paper or document believed by it to be genuine and to have been signed or presented by the proper
party or parties; 
 (ii) whenever in the administration of this Indenture the Trustee shall deem it desirable that a matter be proved or
established prior to taking, suffering or omitting any action hereunder, the Trustee (unless other evidence be herein specifically prescribed) may, in the absence of bad faith on its part, request and conclusively rely upon an Officers’
Certificate; 
 (iii) the Trustee may execute any of the trusts or powers hereunder or perform any duties hereunder either directly or by or
through agents or attorneys and the Trustee shall not be responsible for any misconduct or negligence on the part of any agent or attorney appointed with due care by it hereunder; 
 (iv) the Trustee shall not be liable for any action taken, suffered, or omitted to be taken by it in good faith which it believes to be authorized or
within its rights or powers conferred under this Indenture; 
 (v) the Trustee may consult with counsel selected by it and any advice or
Opinion of Counsel shall be full and complete authorization and protection in respect of any action taken or suffered or omitted by it hereunder in good faith and in accordance with such advice or Opinion of Counsel; 
 (vi) the Trustee shall be under no obligation to exercise any of the rights or powers vested in it by this Indenture at the request, order or direction
of any of the Holders, pursuant to the provisions of this Indenture, unless such Holders shall have offered to the Trustee security or indemnity satisfactory to it against the costs, expenses and liabilities which may be incurred therein or thereby;

 (vii) any request or direction of the Company mentioned herein shall be sufficiently evidenced by a Company Request or Company Order and
any resolution of the Board of Directors may be sufficiently evidenced by a resolution of the Board of Directors; 
 (viii) the Trustee shall
not be bound to make any investigation into the facts or matters stated in any resolution, certificate, statement, instrument, opinion, report, notice, request, direction, consent, order, bond, debenture, note, other evidence of indebtedness or
other paper or 

  

 37 

 
document, including, without limitation, any Company Request, Company Order or Officers’ Certificate, but the Trustee, in its discretion, may make such
further inquiry or investigation into such facts or matters as it may see fit, and, if the Trustee shall determine to make such further inquiry or investigation, it shall be entitled to examine the books, records and premises of the Company,
personally or by agent or attorney at the sole cost of the Company and shall incur no liability or additional liability of any kind by reason of such inquiry or investigation or lack thereof; 
 (ix) the Trustee shall not be deemed to have notice of any Default or Event of Default unless a Responsible Officer of the Trustee received written
notice of an event which is in fact such a Default or Event of Default, and such notice references the Securities and this Indenture, describes the event with specificity, and alleges that the occurrence of this event is a Default or an Event of
Default under this Indenture; 
 (x) the rights, privileges, protections, immunities and benefits given to the Trustee, including, without
limitation, its right to be indemnified, are extended to, and shall be enforceable by, the Trustee in each of its capacities hereunder, and to each agent, custodian and other Person employed to act hereunder; 
 (xi) the Trustee may request that the Company deliver an Officers’ Certificate setting forth the names of individuals and/or titles of officers
authorized at such time to take specified actions pursuant to this Indenture, which Officers’ Certificate may be signed by any person authorized to sign an Officers’ Certificate, including any person specified as so authorized in any such
certificate previously delivered and not superseded; and 
 (xii) the permissive rights of the Trustee enumerated herein shall not be
construed as duties. 
 Section 7.03. Individual Rights of Trustee. 
 The Trustee in its individual or any other capacity may become the owner or pledgee of Securities and may otherwise deal with the Company or its
Affiliates with the same rights it would have if it were not Trustee. Any Paying Agent, Registrar, Conversion Agent or co-registrar may do the same with like rights. However, the Trustee must comply with Section 7.10. 
 Section 7.04. Trustee’s Disclaimer. 
 The Trustee makes no representation as to the validity or adequacy of this Indenture or the Securities, it shall not be accountable for the Company’s use or application of the proceeds from the Securities, it shall not be responsible
for any statement in the registration statement for the Securities under the Securities Act or in the Indenture or the Securities (other than its certificate of authentication), or the determination as to which beneficial owners are entitled to
receive any notices hereunder. 
  

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 Section 7.05. Notice of Defaults. 
 If a Default occurs and if it is known to the Trustee, the Trustee shall give to each Holder notice of the Default within 90 days after the Trustee gains
knowledge of the Default unless such Default shall have been cured or waived before the giving of such notice. Except in the case of a Default described in Section 6.01(1) or (2), the Trustee may withhold the notice if and so long as a
committee of its Responsible Officers in good faith determines that withholding the notice is in the interests of Holders. The second sentence of this Section 7.05 shall be in lieu of the proviso to Section 315(b) of the TIA and such
proviso is hereby expressly excluded from this Indenture, as permitted by the TIA. The Trustee shall not be deemed to have knowledge of a Default unless a Responsible Officer of the Trustee has received written notice of such Default in the manner
described in Section 7.02(i). 
 Section 7.06. Reports by Trustee to Holders. 
 Within 60 days after each May 15 beginning with May 15, 2007, the Trustee shall transmit to each Holder such reports as may be required under
Section 313 of the TIA. 
 Section 7.07. Compensation and Indemnity. 
 The Company agrees: 
 (i) to pay to the
Trustee from time to time such reasonable compensation as the Company and the Trustee shall from time to time agree in writing for all services rendered by it hereunder (which compensation shall not be limited (to the extent permitted by law) by any
provision of law in regard to the compensation of a trustee of an express trust); 
 (ii) to reimburse the Trustee upon its request for all
reasonable expenses, disbursements and advances incurred or made by the Trustee in accordance with any provision of this Indenture (including the reasonable compensation and the expenses, advances and disbursements of its agents and counsel), except
any such expense, disbursement or advance as may be attributable to its negligence or bad faith; and 
 (iii) to indemnify the Trustee or any
predecessor Trustee and their agents for, and to hold them harmless against, any loss, damage, claim, liability, cost or expense (including reasonable attorney’s fees and expenses and taxes (other than taxes based upon, measured by or
determined by the income of the Trustee)) reasonably incurred without negligence or bad faith on its part, arising out of or in connection with the acceptance or administration of this trust, including the reasonable costs and expenses of defending
itself against any claim (whether asserted by the Company or any Holder or any other Person) or liability in connection with the acceptance, exercise or performance of any of its powers or duties hereunder. 
 To secure the Company’s payment obligations in this Section 7.07, Holders shall have been deemed to have granted to the Trustee a lien prior to
the Securities on all money or property held or collected by the Trustee, except that held in trust to pay the Principal Amount, Change in Control Purchase Price, or interest, as the case may be, on particular Securities. 
  

 39 

 The Company’s payment obligations pursuant to this Section 7.07 shall survive the discharge of
this Indenture and the resignation or removal of the Trustee. When the Trustee incurs expenses after the occurrence of a Default specified in Section 6.01(5) or (6), its expenses including the reasonable charges and expenses of its counsel, are
intended to constitute expenses of administration under any Bankruptcy Law. 
 Section 7.08. Replacement of Trustee. 
 The Trustee may resign by so notifying the Company; provided, however, no such resignation shall be effective until a successor Trustee has
accepted its appointment pursuant to this Section 7.08. The Holders of a majority in aggregate Principal Amount of the Securities at the time outstanding may remove the Trustee by so notifying the Trustee and the Company. The Company shall
remove the Trustee if: 
 (1) the Trustee fails to comply with Section 7.10; 
 (2) the Trustee is adjudged bankrupt or insolvent; 
 (3) a receiver or public officer takes charge of the Trustee or its property; or 
 (4) the Trustee otherwise becomes incapable of acting. 
 If the Trustee resigns or is removed or if a vacancy exists in the office of Trustee for any reason, the Company shall promptly appoint, by resolution of the Board of Directors, a successor Trustee. 
 A successor Trustee shall deliver a written acceptance of its appointment to the retiring Trustee and to the Company satisfactory in form and substance
to the retiring Trustee and the Company. Thereupon the resignation or removal of the retiring Trustee shall become effective, and the successor Trustee shall have all the rights, powers and duties of the Trustee under this Indenture. The successor
Trustee shall mail a notice of its succession to Holders. The retiring Trustee shall promptly transfer all property held by it as Trustee to the successor Trustee, subject to the lien provided for in Section 7.07. 
 If a successor Trustee does not take office within 30 days after the retiring Trustee resigns or is removed, the retiring Trustee, the Company or the
Holders of a majority in aggregate Principal Amount of the Securities at the time outstanding may petition any court of competent jurisdiction at the expense of the Company for the appointment of a successor Trustee. 
 If the Trustee fails to comply with Section 7.10, any Holder may petition any court of competent jurisdiction for the removal of the Trustee and the
appointment of a successor Trustee. 
 The resignation or removal of a Trustee shall not diminish, impair or terminate its rights to
indemnification pursuant to Section 7.07 as they relate to periods prior to such resignation or removal. 
  

 40 

 Section 7.09. Successor Trustee by Merger. 
 If the Trustee consolidates with, merges or converts into, or transfers all or substantially all its corporate trust business or assets to, another
corporation, the resulting, surviving or transferee corporation without any further act shall be the successor Trustee. 
 Section 7.10.
Eligibility; Disqualification. 
 There shall at all times be a Trustee hereunder which shall be eligible to act as Trustee and shall
have a combined capital and surplus of at least $50,000,000. If such corporation publishes reports of condition at least annually, pursuant to law or to the requirements of federal, state, territorial or District of Columbia supervising or examining
authority, then, for the purposes of this Section 7.10, the combined capital and surplus of such corporation shall be deemed to be its combined capital and surplus as set forth in its most recent report of condition so published. If at any time
the Trustee shall cease to be eligible in accordance with the provisions of this Section 7.10, it shall resign immediately in the manner and with the effect hereinafter specified in this Article 7. 
 ARTICLE 8 
 DISCHARGE
OF INDENTURE 
 Section 8.01. Discharge of Liability on Securities. 
 When (i) the Company delivers to the Trustee all outstanding Securities (other than Securities replaced pursuant to Section 2.07) for
cancellation or (ii) all outstanding Securities have become due and payable and the Company deposits with the Trustee, the Paying Agent (if the Paying Agent is not the Company or any Subsidiary or any Affiliate of either of them) or the
Conversion Agent cash or, if expressly permitted by the terms of the Securities and the Indenture, Common Stock (solely to satisfy the rights of Holders granted in Article 10) or governmental obligations sufficient to pay all amounts due and owing
on all outstanding Securities (other than Securities replaced pursuant to Section 2.07), and if in either case the Company pays all other sums payable hereunder by the Company, then this Indenture shall, subject to Section 7.07, cease to
be of further effect. The Trustee shall join in the execution of a document prepared by the Company acknowledging satisfaction and discharge of this Indenture on demand of the Company accompanied by an Officers’ Certificate stating that the
consideration being given is expressly permitted by the terms of the Securities and that all conditions precedent to the discharge of the Indenture have been complied with by the Company and an Opinion of Counsel that such satisfaction and discharge
does not violate the terms of this Indenture or the Securities, and at the cost and expense of the Company. The Trustee shall be allowed to conclusively rely on such Officers’ Certificate and Opinion of Counsel. 
 Section 8.02. Repayment to the Company. 
 The Trustee and the Paying Agent shall return to the Company upon written request any money or securities held by them for the payment of any amount with respect to the Securities that remains unclaimed for two years, subject to applicable
unclaimed property law. After return to the Company, Holders entitled to the money or securities must look to the Company for 

  

 41 

 
payment as general creditors unless an applicable abandoned property law designates another person and the Trustee and the Paying Agent shall have no further
liability to the Holders with respect to such money or securities for that period commencing after the return thereof. 
 ARTICLE 9

 AMENDMENTS 
 Section 9.01. Without Consent of Holders. 
 The Company and the Trustee may amend this Indenture or the Securities without
the consent of any Holder: 
 (1) to cure any ambiguity, omission, defect or inconsistency; 
 (2) to comply with Article 5 or Section 10.16; 
 (3) to secure the Company’s obligations under the Securities and this Indenture; 
 (4) to add to the Company’s covenants for the benefit of the Holders or to surrender any right or power conferred upon the Company;

 (5) to make any change to comply with the TIA, or any amendment thereto, or to comply with any requirement of the SEC in
connection with the qualification of the Indenture under the TIA, or as necessary in connection with the registration of the Securities under the Securities Act if at any time the Company seeks to register the Securities thereunder; or 

(6) to make any change that does not adversely affect the rights of any Holder. 
 No amendment to cure any ambiguity, omission, defect or inconsistency in this Indenture made solely to conform the Indenture to the description of the
Securities contained in the offering memorandum pursuant to which the Securities have been initially offered shall be deemed to adversely affect the interests of the Holders. 
 Section 9.02. With Consent of Holders. 
 With the written consent of the Holders of at least a majority in aggregate Principal Amount of the Securities at the time outstanding, the Company and the Trustee may amend this Indenture or the Securities. However, without the consent of
each Holder affected, an amendment to this Indenture or the Securities may not: 
 (1) reduce the Principal Amount, or Change
in Control Purchase Price with respect to or any premium or interest (including Additional Interest) on any Security; 
 (2)
make any Security payable in money or securities other than that stated in the Security; 
  

 42 

 (3) change the Stated Maturity of any Security; 
 (4) make any change that adversely affects the right of a Holder to convert any Security; 
 (5) make any change that adversely affects the right to require the Company to purchase the Securities in accordance with the terms
thereof and this Indenture; 
 (6) impair the right to convert or receive payment with respect to, a Security, or right to
institute suit for the enforcement of any payment with respect to, or conversion of, the Securities; or 
 (7) make any change
in Section 6.04, Section 6.07 or this Section 9.02, except to increase any percentage set forth therein. 
 It shall not be
necessary for the consent of the Holders under this Section 9.02 to approve the particular form of any proposed amendment, but it shall be sufficient if such consent approves the substance thereof. 
 After an amendment under this Section 9.02 becomes effective, the Company shall mail to each Holder a notice briefly describing the amendment.
Failure to mail such notice or a defect in the notice shall not affect the validity of the amendment. 
 Section 9.03. Compliance with
Trust Indenture Act. 
 Every supplemental indenture executed pursuant to this Article shall comply with the TIA. 
 Section 9.04. Revocation and Effect of Consents, Waivers and Actions. 
 Until an amendment, waiver or other action by Holders becomes effective, a consent thereto by a Holder of a Security hereunder is a continuing consent by
the Holder and every subsequent Holder of that Security or portion of the Security that evidences the same obligation as the consenting Holder’s Security, even if notation of the consent, waiver or action is not made on the Security. However,
any such Holder or subsequent Holder may revoke the consent, waiver or action as to such Holder’s Security or portion of the Security if the Trustee receives the notice of revocation before the date the amendment, waiver or action becomes
effective. After an amendment, waiver or action becomes effective, it shall bind every Holder. 
 Section 9.05. Notation on or Exchange of
Securities. 
 Securities authenticated and delivered after the execution of any supplemental indenture pursuant to this Article 9
may, and shall if required by the Trustee, bear a notation in form approved by the Trustee as to any matter provided for in such supplemental indenture. If the Company shall so determine, new Securities so modified as to conform, in the opinion of
the Board of Directors, to any such supplemental indenture may be prepared and executed by the Company and authenticated and delivered by the Trustee in exchange for outstanding Securities. 
  

 43 

 Section 9.06. Trustee to Sign Supplemental Indentures. 
 The Trustee shall sign any supplemental indenture authorized pursuant to this Article 9 if the amendment contained therein does not adversely affect the
rights, duties, liabilities or immunities of the Trustee. If it does, the Trustee may, but need not, sign such supplemental indenture. In signing such supplemental indenture the Trustee shall receive, and (subject to the provisions of
Section 7.01) shall be fully protected in relying upon, in addition to the documents required by Section 12.04, an Officers’ Certificate and an Opinion of Counsel stating that such amendment is authorized or permitted by this
Indenture. 
 Section 9.07. Effect of Supplemental Indentures. 
 Upon the execution of any supplemental indenture under this Article, this Indenture shall be modified in accordance therewith, and such supplemental
indenture shall form a part of this Indenture for all purposes; and every Holder of Securities theretofore or thereafter authenticated and delivered hereunder shall be bound thereby. 
 ARTICLE 10 
 CONVERSION 
 Section 10.01. Conversion Privilege. 
 A Holder of a Security may convert such Security at any time during the period stated in paragraph 6 of the Securities upon the occurrence of any of the events set forth in paragraph 6 of the Securities, subject to the provisions of this
Article 10. Subject to certain exceptions described in paragraph 6 of the Securities and Section 10.23, if a Holder surrenders its Securities for conversion, such holder will receive, in respect of each $1,000 of Principal Amount, the
Conversion Value which shall be paid as follows: 
 (A) Cash in an amount equal to the lesser of (1) $1,000 and
(2) the Conversion Value (the “Required Cash Amount”); and 
 (B) if the Conversion Value is greater
than $1,000, a number of shares of Common Stock (the “Remaining Shares”), equal to the sum of the Daily Share Amounts for each of the ten consecutive Trading Days in the Conversion Reference Period, subject to the right of the
Company to deliver cash in lieu of all or a portion of such Remaining Shares as described in this Section 10.01. 
 On any day prior to
the first Trading Day of the applicable Conversion Reference Period, the Company may specify a percentage of the Daily Share Amount that will be settled in cash (the “Cash Percentage”) and will notify the Holders of such Cash
Percentage through written notice to the Trustee (the “Cash Percentage Notice”). If the Company elects to specify a Cash Percentage, the amount of cash that the Company will deliver in respect of each Trading Day in the applicable
Conversion Reference Period will equal the product of: (1) the Cash Percentage, (2) the Daily Share Amount for such Trading Day, and (3) the Volume Weighted Average Price of the Common Stock for such Trading Day (provided that
after the consummation of a Change in Control in which the consideration is comprised entirely of cash, the amount used in this 

  

 44 

 
clause (3) will be the cash price per share of Common Stock received by holders of Common Stock in such Change in Control). The number of shares
deliverable in respect of each Trading Day in the applicable Conversion Reference Period will be a percentage of the Daily Share Amount equal to 100% minus the Cash Percentage. If the Company does not specify a Cash Percentage by the start of the
applicable Conversion Reference Period, the Company shall settle 100% of the Daily Share Amount for each Trading Day in the applicable Conversion Reference Period with shares of Common Stock; provided, however, that the Company will pay cash
in lieu of fractional shares otherwise issuable upon conversion of such Security, pursuant to Section 10.03 hereof. The Company may, at its option, revoke any Cash Percentage Notice through written notice to the Trustee prior to the start of
the applicable Conversion Reference Period. 
 A Holder may convert a portion of the Principal Amount of a Security if the portion is $1,000
or an integral multiple of $1,000. Provisions of this Indenture that apply to conversion of all of a Security also apply to conversion of a portion of a Security. 
 In the event of a stock split, combination, dividend or any other event resulting in an adjustment to the Conversion Rate pursuant to Sections 10.06, 10.07, 10.08, 10.09 or 10.10, during the applicable Conversion
Reference Period, appropriate adjustment to the equation for calculating Conversion Value shall be made, as determined by the Board of Directors. 
 Section 10.02. Conversion Procedure. 
 To convert a Security, a Holder must satisfy the requirements in paragraph 6 of the
Securities. The Conversion Agent shall, within one (1) Business Day of the Conversion Date, provide notice to the Company as set forth in Section 12.02(b). 
 As promptly as practicable following the end of the Conversion Reference Period applicable to the Securities being converted, the Company shall deliver to the Holder, through the Conversion Agent, the Required Cash
Amount and Net Share Amount, if any (including cash in lieu of fractional shares pursuant to Section 10.03 hereof). The person in whose name the certificate representing any shares is registered shall be treated as a stockholder of record on
and after the Conversion Date; provided, however, that no surrender of a Security on any date when the stock transfer books of the Company shall be closed shall be effective to constitute the person or persons entitled to receive the Net
Share Amount upon such conversion as the record holder or holders of such shares of Common Stock on such date, but such surrender shall be effective to constitute the person or persons entitled to receive such shares of Common Stock as the record
holder or holders thereof for all purposes at the Close of Business on the next succeeding day on which such stock transfer books are open; such conversion shall be at the Conversion Rate in effect on the date that such Security shall have been
surrendered for conversion, as if the stock transfer books of the Company had not been closed. Upon conversion of a Security, such person shall no longer be a Holder of such Security. 
 No payment or adjustment will be made for dividends on, or other distributions with respect to, any Common Stock except as provided in this Article 10.
On conversion of a Security, accrued interest with respect to the converted Security shall not be cancelled, extinguished or forfeited, but rather shall be deemed to be paid in full to the Holder thereof through delivery of the Required Cash Amount
and the Net Share Amount, if any (together with 

  

 45 

 
the cash payment, if any, in lieu of fractional shares) in exchange for the Security being converted pursuant to the provisions hereof. 
 If the Holder converts more than one Security at the same time, the Required Cash Amount and the Net Share Amount, if any (together with the cash
payment, if any, in lieu of fractional shares) shall be based on the total Principal Amount of the Securities converted. 
 If the last day
on which a Security may be converted is a Legal Holiday, the Security may be surrendered on the next succeeding day that is not a Legal Holiday. 
 Upon surrender of a Security that is converted in part, the Company shall execute, and the Trustee shall authenticate and deliver to the Holder, a new Security in an authorized denomination equal in Principal Amount to the unconverted
portion of the Security surrendered. 
 Section 10.03. Fractional Shares. 
 The Company will not issue a fractional share of Common Stock upon conversion of a Security. Instead, the Company will deliver cash for the current
market value of the fractional share. The current market value of a fractional share shall equal the arithmetic average of the Volume Weighted Average Price of the Common Stock for each of the ten consecutive Trading Days of the Conversion
Reference Period, rounded to the nearest whole cent. 
 Section 10.04. Taxes on Conversion. 
 If a Holder converts a Security, the Company shall pay any documentary, stamp or similar issue or transfer tax due on the issue of any shares of Common
Stock upon the conversion. However, the Holder shall pay any such tax which is due because the Holder requests the shares to be issued in a name other than the Holder’s name. The Conversion Agent may refuse to deliver the certificates
representing the Common Stock being issued in a name other than the Holder’s name until the Conversion Agent receives a sum sufficient to pay any tax which will be due because the shares are to be delivered in a name other than the
Holder’s name. Nothing herein shall preclude any tax withholding required by law or regulations. 
 Section 10.05. Company to Provide
Stock. 
 The Company shall, prior to issuance of any Securities under this Article 10, and from time to time as may be necessary,
reserve out of its authorized but unissued Common Stock a sufficient number of shares of Common Stock to permit the payment of the Remaining Shares, if applicable, upon conversion of the Securities. 
 All shares of Common Stock delivered upon payment of any Remaining Shares, if applicable, upon conversion of the Securities shall be newly issued shares
or treasury shares, shall be duly and validly issued and fully paid and nonassessable and shall be free from preemptive rights and free of any lien or adverse claim. 
 The Company will comply with all federal and state securities laws regulating the offer and delivery of shares of Common Stock upon payment of any Remaining Shares, if applicable, upon conversion of Securities, if
any, and will list or cause to have quoted such shares of 

  

 46 

 
Common Stock on each national securities exchange or in the over-the-counter market or such other market on which the Common Stock is then listed or quoted.

 Section 10.06. Adjustment for Change in Capital Stock. 
 If, after the Issue Date of the Securities, the Company: 
 (1) pays a dividend or makes a distribution on its Common Stock payable in shares of its Common Stock or shares of other Capital Stock; 
 (2) subdivides or combines its shares of Common Stock; or 
 (3) issues by reclassification of its Common Stock any shares of its Capital Stock (other than rights, warrants or options for its Capital
Stock), 
 then the Conversion Rate in effect immediately prior to such action shall be adjusted so that the Holder of a Security thereafter converted may
receive the number of shares of Capital Stock of the Company which such Holder would have owned immediately following such action if such Holder had converted the Security immediately prior to such action. 
 The adjustment shall become effective immediately after the record date in the case of a dividend or distribution and immediately after the effective
date in the case of a subdivision, combination or reclassification. 
 If after an adjustment a Holder of a Security upon conversion of such
Security may receive shares of two or more classes of Capital Stock of the Company, the Conversion Rate shall thereafter be subject to adjustment upon the occurrence of an action taken with respect to any such class of Capital Stock as is
contemplated by this Article 10 with respect to the Common Stock, on terms comparable to those applicable to Common Stock in this Article 10. 
 Section 10.07. Adjustment for Rights Issue. 
 If, after the Issue Date of the Securities, the Company distributes any
rights, warrants or options to all holders of its Common Stock entitling them, for a period expiring within 60 days after the record date for such distribution, to purchase shares of Common Stock at a price per share less than the Average Closing
Price, the Conversion Rate shall be adjusted in accordance with the formula: 
  

					
	R’ = R x 	  	(O + N)	  	
	  	(O + (N x P) /M)	  	

 where, 
 R’ = the adjusted Conversion Rate. 
 R = the current Conversion Rate. 
 O = the number of shares of Common Stock outstanding on the record date for the distribution to which this Section 10.07 is being applied.

  

 47 

 N = the number of additional shares of Common Stock offered pursuant to the distribution. 
 P = the offering price per share of the additional shares. 
 M = the Average Closing Price, minus, in the case of (i) a distribution to which Section 10.06(3) applies or (ii) a distribution to which Section 10.08 applies, for which, in each case,
(x) the record date shall occur on or before the record date for the distribution to which this Section 10.07 applies and (y) the Ex-Dividend Time shall occur on or after the date of the first public announcement for the distribution
to which this Section 10.07 applies, the fair market value (on the record date for the distribution to which this Section 10.07 applies) of the 
 (1) Capital Stock of the Company distributed in respect of each share of Common Stock in such Section 10.06(3) distribution and 
 (2) assets of the Company or debt securities or any rights, warrants or options to purchase securities of the Company distributed in
respect of each share of Common Stock in such Section 10.08 distribution. 
 The Board of Directors shall determine fair market values
for the purposes of this Section 10.07. 
 In the event the Company makes a distribution pursuant to this Section 10.07 the Company
will be required to give notice to the holders of Securities at least 20 days prior to the Ex-Dividend Date, as defined below, for such distribution. 
 The adjustment shall become effective immediately after the record date for the determination of shareholders entitled to receive the rights, warrants or options to which this Section 10.07 applies. If all of the
shares of Common Stock subject to such rights, warrants or options have not been issued when such rights, warrants or options expire, then the Conversion Rate shall promptly be readjusted to the Conversion Rate that would then be in effect had the
adjustment upon the issuance of such rights, warrants or options been made on the basis of the actual number of shares of Common Stock issued upon the exercise of such rights, warrants or options. 
 No adjustment shall be made under this Section 10.07 if the application of the formula stated above in this Section 10.07 would result in a
value of R’ that is equal to or less than the value of R. 
 Section 10.08. Adjustment for Other Distributions. 
 (i) If, after the Issue Date of the Securities, the Company distributes to all holders of its Common Stock any of its assets (including shares of any
Subsidiary or business unit of the Company, but excluding distributions of Capital Stock or equity interests referred to in Section 10.08(b)), or debt securities or any rights, warrants or options to purchase securities of the Company
(including securities or cash, but excluding (x) distributions of Capital Stock referred to in Section 10.06 and distributions of rights, warrants or options referred to in Section 10.07 

  

 48 

 
and (y) cash dividends or other cash distributions referred to in Section 10.09), the Conversion Rate shall be adjusted, subject to the provisions
of Section 10.08(c), in accordance with the formula: 
  

					
	R’ = 	  	    R x M    	  	
	  	M - F	  	

 where, 
 R’ = the adjusted Conversion Rate. 
 R = the current Conversion Rate. 
 M = the Average Closing Price, minus, in the case of a distribution to which Section 10.06(1) applies, for which (i) the record date shall
occur on or before the record date for the distribution to which this Section 10.08(a) applies and (ii) the Ex-Dividend Time shall occur on or after the date of the Time of Determination for the distribution to which this
Section 10.08(a) applies, the fair market value (on the record date for the distribution to which this Section 10.08(a) applies) of any Capital Stock of the Company distributed in respect of each share of Common Stock in such
Section 10.06(1) distribution. 
 F = the fair market value (on the record date for the distribution to which this Section 10.08(a)
applies) of the assets, securities, rights, warrants or options to be distributed in respect of each share of Common Stock in the distribution to which this Section 10.08(a) is being applied (including, in the case of cash dividends or other
cash distributions giving rise to an adjustment, all such cash distributed concurrently). 
 The Board of Directors shall determine fair
market values for the purposes of this Section 10.08(a). 
 The adjustment shall become effective immediately after the record date for
the determination of shareholders entitled to receive the distribution to which this Section 10.08(a) applies. 
 (ii) If, after the
Issue Date of the Securities, the Company pays a dividend or makes a distribution to all holders of its Common Stock consisting of Capital Stock of any class or series, or similar equity interests, of or relating to a Subsidiary or other business
unit of the Company, then the Conversion Rate shall be adjusted in accordance with the formula: 
 R’ = R x (1 + F/M) 
 R’ = the adjusted Conversion Rate. 
 R
= the current Conversion Rate. 
 M = the average of the Post-Distribution Prices of the Common Stock for the 10 Trading Days commencing on
and including the fifth Trading Day after the date on which “ex-dividend trading” commences for such dividend or distribution on the principal United States exchange or market which such securities are then listed or quoted (the
“Ex-Dividend Date”). 
  

 49 

 F = the fair market value of the securities distributed in respect of each share of Common Stock for
which this Section 10.08(b) shall mean the number of securities distributed in respect of each share of Common Stock multiplied by the average of the Post-Distribution Prices of those securities distributed for the ten Trading Days commencing
on and including the fifth Trading Day after the Ex-Dividend Date. 
 “Post-Distribution Price” of Capital Stock or any
similar equity interest on any date means the closing per unit sale price (or, if no closing sale price is reported, the average of the bid and ask prices or, if more than one in either case, the average of the average bid and the average ask
prices) on such date for trading of such units on a “when issued” basis without due bills (or similar concept) as reported in the composite transactions for the principal United States securities exchange on which such Capital Stock or
equity interest is traded or, if the Capital Stock or equity interest, as the case may be, is not listed on a United States national or regional securities exchange, as reported by the National Association of Securities Dealers Automated Quotation
System or by the National Quotation Bureau Incorporated; provided that if on any date such units have not traded on a “when issued” basis, the Post-Distribution Price shall be the closing per unit sale price (or, if no closing sale
price is reported, the average of the bid and ask prices or, if more than one in either case, the average of the average bid and the average ask prices) on such date for trading of such units on a “regular way” basis without due bills (or
similar concept) as reported in the composite transactions for the principal United States securities exchange on which such Capital Stock or equity interest is traded or, if the Capital Stock or equity interest, as the case may be, is not listed on
a United States national or regional securities exchange, as reported by the National Association of Securities Dealers Automated Quotation System or by the National Quotation Bureau Incorporated. In the absence of such quotation, the Company shall
be entitled to determine the Post-Distribution Price on the basis of such quotations which reflect the post-distribution value of the Capital Stock or equity interests as it considers appropriate. 
 (iii) In the event that, with respect to any distribution to which Section 10.08(a) would otherwise apply, the difference “M-F” as defined
in the formula set forth in Section 10.08(a) is less than $1.00 or “F” is equal to or greater than “M”, then the adjustment provided by Section 10.08(a) shall not be made and in lieu thereof the provisions of
Section 10.15 shall apply to such distribution. 
 (iv) In the event the Company makes a distribution pursuant to this
Section 10.08 which has a per share value equal to more than 15% of the Closing Price of shares of Common Stock on the day preceding the declaration date for such distribution, the Company will be required to give notice to the holders of
Securities at least 20 days prior to the Ex-Dividend Date, as defined below, for such distribution. 
  

 50 

 Section 10.09. Adjustment for Cash Dividends. 
 (i) If, after the Issue Date of the Securities, the Company distributes to all or substantially all holders of its Common Stock any cash (excluding any
dividend or distribution in connection with the liquidation, dissolution or winding up of the Company, whether voluntary or involuntary), the Conversion Rate shall be adjusted, subject to the provisions of Section 10.13 in accordance with the
formula: 
  

					
	R’ = R x 	  	M	  	
	  	(M – C)	  	

 where, 
 R’ = the adjusted Conversion Rate; 
 R = the Conversion Rate in effect immediately prior to the Time of
Determination; 
 M = the Average Closing Price; and 
 C = the amount in cash per share the Company distributes to holders of the Common Stock (and for which no adjustment has been made). 
 Section 10.10. Adjustment for Tender Offer. 
 If, after the Issue Date, the Company makes a payment
of cash or other consideration by the Company or any of its subsidiaries to holders of Common Stock in respect of a tender offer or exchange offer, other than an odd-lot offer, for the Common Stock, and the value of the sum of (i) the aggregate
cash and other consideration paid for such Common Stock, and (ii) the aggregate fair market value of any consideration paid for the purchase of Common Stock in respect of a tender offer or exchange offer, other than an odd-lot offer, within the
twelve (12) months preceding the date of purchase of such shares of Common Stock in respect of which no adjustment pursuant to this Section 10.10 previously has been made, expressed as an amount per share of Common Stock validly tendered
or exchanged pursuant to such tender offer or exchange offer, exceeds the Closing Price of the Common Stock on the Trading Day immediately following the last time (the “Expiration Time”) on which tenders or exchanges may be made
pursuant to the tender or exchange offer, then the Conversion Rate shall be adjusted in accordance with the formula: 
  

					
	R’ = R x 	  	F + (P x O)	  	
	  	O’ x P	  	

 where, 
 R = the Conversion Rate in effect on the Expiration Time; 
 R’ = the Conversion Rate in effect
immediately after the Expiration Time; 
 F = the fair market value (as determined by the Board of Directors) of the aggregate value of all
cash and any other consideration paid or payable for shares of Common Stock validly tendered or exchanged and not withdrawn as of the Expiration Time (the “Purchased Shares”); 
 O = the number of shares of Common Stock outstanding immediately after the Expiration Time less any Purchased Shares; 
 O’ = the number of shares of Common Stock outstanding immediately after the Expiration Time, including any Purchased Shares; and 
  

 51 

 P = the Closing Price of the Common Stock on the Trading Day next succeeding the Expiration Time.

 Such increase (if any) shall become effective immediately prior to the opening of business on the day following the Expiration Time. In
the event that the Company is obligated to purchase shares pursuant to any such tender offer, but the Company is prevented by applicable law from effecting any such purchases or all such purchases are rescinded, the Conversion Rate shall again be
adjusted to be the Conversion Rate that would then be in effect if such tender or exchange offer had not been made. If the application of this Section 10.10 to any tender or exchange offer would result in a decrease in the Conversion Rate, no
adjustment shall be made for such tender or exchange offer under this Section 10.10. 
 Section 10.11. Adjustment to Conversion Rate
Upon Change in Control Transactions. 
 If, after the Issue Date, a Change in Control occurs and a Holder elects to convert its
Securities in connection with such Change in Control, the Company will increase the Applicable Conversion Rate for the Securities surrendered for conversion by a number of additional shares of Common Stock (the “Make-Whole Shares”),
as described in this Section 10.11. A conversion of Securities will be deemed for the purposes of this Section 10.11 to be “in connection with” a Change in Control transaction if the notice of conversion of the Securities is
received by the Conversion Agent from and including the effective date of the Change in Control, up to and including the Trading Day prior to the related Change in Control Purchase Date. 
 The number of Make-Whole Shares will be determined by reference to the table below and is based on the date which such Change in Control transaction
becomes effective (the “Change in Control Effective Date”) and the price (the “Stock Price”) paid per share of Common Stock in such Change in Control transaction. If the holders of Common Stock receive only cash in
the Change in Control transaction, the Stock Price shall be the cash amount paid per share of Common Stock. Otherwise, the Stock Price shall be the average of the closing sale prices of the Common Stock on the ten consecutive Trading Days up to but
excluding the Change in Control Effective Date. 
 The Stock Prices set forth in the first column of the table below will be adjusted as of
any date on which the Conversion Rate is adjusted. The adjusted Stock Prices will equal the Stock Prices applicable immediately prior to such adjustment, multiplied by a fraction, the numerator of which is the Applicable Conversion Rate immediately
prior to the adjustment giving rise to the Stock Price adjustment and the denominator of which is the Applicable Conversion Rate as so adjusted. The number of Make-Whole Shares set forth in the table below will be adjusted at the same time and in
the same manner as the Conversion Rate. 
  

													
	 	  	Effective Date
	 Stock Price on Effective Date
	  	April 25,
2006	  	May 1,
2007	  	May 1,
2008	  	May 1,
2009	  	May 1,
2010	  	May 1,
2011
	 $65.13
	  	2.4515	  	2.4515	  	2.4515	  	2.4515	  	2.4515	  	2.4515
	 $70.00
	  	2.0073	  	2.0159	  	1.9915	  	1.9203	  	1.7426	  	1.3833
	 $75.00
	  	1.6464	  	1.6279	  	1.5708	  	1.4586	  	1.2215	  	0.4309
	 $80.00
	  	1.3605	  	1.3223	  	1.2444	  	1.1092	  	0.8465	  	0.0000

  

 52 

													
	 	  	Effective Date
	 Stock Price on Effective Date
	  	April 25,
2006	  	May 1,
2007	  	May 1,
2008	  	May 1,
2009	  	May 1,
2010	  	May 1,
2011
	 $85.00
	  	1.1324	  	1.0814	  	0.9906	  	0.8457	  	0.5816	  	0.0000
	 $90.00
	  	0.9483	  	0.8895	  	0.7932	  	0.6467	  	0.3977	  	0.0000
	 $95.00
	  	0.7997	  	0.7366	  	0.6387	  	0.4969	  	0.2717	  	0.0000
	 $100.00
	  	0.6784	  	0.6135	  	0.5169	  	0.3839	  	0.1861	  	0.0000
	 $125.00
	  	0.3264	  	0.2719	  	0.1999	  	0.1194	  	0.0383	  	0.0000
	 $150.00
	  	0.1794	  	0.1416	  	0.0985	  	0.0623	  	0.0314	  	0.0000
	 $175.00
	  	0.1196	  	0.1001	  	0.0773	  	0.0529	  	0.0262	  	0.0000
	 $200.00
	  	0.1064	  	0.0878	  	0.0676	  	0.0460	  	0.0225	  	0.0000
	 $250.00
	  	0.0855	  	0.0703	  	0.0542	  	0.0370	  	0.0193	  	0.0000

 If the exact Stock Prices and effective dates are not set forth in the table, then: (i) if
the Stock Price is between two Stock Price amounts in the table or the effective date is between two dates in the table, the Make-Whole Shares issued upon conversion of the Securities will be determined by a straight-line interpolation between the
number of Make-Whole Shares set forth for the higher and lower Stock Price amounts and the two dates in the table, based on a 365-day year, (ii) if the Stock Price exceeds $250.00 per share, subject to adjustment as set forth herein, no
Make-Whole Shares will be issued upon conversion of the Securities; and (iii) if the Stock Price is less than $65.13 per share, subject to adjustment as set forth herein, no Make-Whole Shares will be issued upon conversion of the Securities.

 Section 10.12. When Adjustment May Be Deferred. 
 No adjustment in the Conversion Rate need be made unless the adjustment would require an increase or decrease of at least 1% of the Conversion Rate. Any adjustments that are less than 1% of the Conversion Rate shall
be carried forward and taken into account in determining any subsequent adjustment. In addition, the Company shall make and pay any carry forward adjustments not otherwise effected upon conversion of any Security, upon required purchase of the
Securities pursuant to Section 3.01, and five Business Days prior to the Stated Maturity. 
 Section 10.13. When No Adjustment
Required; Conversion Rate Cap. 
 No adjustment need be made for a transaction referred to in Section 10.06, 10.07, 10.08, 10.09,
10.10 or 10.16 if Holders are to participate in the transaction on a basis and with notice that the Board of Directors determines to be fair and appropriate in light of the basis and notice on which holders of Common Stock participate in the
transaction. Such participation by Holders may include participation upon conversion; provided that an adjustment shall be made at such time as the Holders are no longer entitled to participate. 
 No adjustment need be made for rights to purchase Common Stock pursuant to a Company plan for reinvestment of dividends or interest. 
 No adjustment need be made for a change in the par value or no par value of the Common Stock. 
 To the extent the Securities become convertible pursuant to this Article 10 into cash, no adjustment need be made thereafter as to the cash. Interest
will not accrue on the cash. 
  

 53 

 Notwithstanding the provisions of this Article 10, in no event shall the Conversion Rate exceed
15.3539 per $1,000 Principal Amount of the Securities on account of adjustments to the Conversion Rate described in Section 10.11, subject to the adjustments set forth in clauses 10.06, 10.07, 10.08, 10.09 and 10.10. Further,
notwithstanding anything in Article 10, the Conversion Rate shall not exceed 66.6667 per $1,000 Principal Amount of the Securities other than as a result of proportional adjustments to the Conversion Rate described in Sections 10.06, 10.07 and
10.08. 
 Section 10.14. Notice of Adjustment. 
 Whenever the Conversion Rate is adjusted, the Company shall promptly mail to Holders a notice of the adjustment. The Company shall file with the Trustee and the Conversion Agent such notice and a certificate from the
Company’s independent public accountants briefly stating the facts requiring the adjustment and the manner of computing it. The certificate shall be conclusive evidence that the adjustment is correct. Neither the Trustee nor any Conversion
Agent shall be under any duty or responsibility with respect to any such certificate except to exhibit the same to any Holder desiring inspection thereof. 
 All calculations under this Article 10 shall be made to the nearest cent or to the nearest 1/1,000th of a share, as the case may be (with one-half cent and 5/10,000ths of a share being rounded upward). 
 Section 10.15. Notice of Certain Transactions. 
 If: 
 (1) the Company takes any action that would require an adjustment in the Conversion
Rate pursuant to Section 10.06, 10.07, 10.08, 10.09, 10.10 or 10.11 (unless no adjustment is to occur pursuant to Section 10.13); or 
 (2) the Company takes any action that would require a supplemental indenture pursuant to Section 10.16; or 
 (3) there is a liquidation or dissolution of the Company; 
 then the Company shall mail to Holders and file with the Trustee
and the Conversion Agent a notice stating the proposed record date for a dividend or distribution or the proposed effective date of a subdivision, combination, reclassification, consolidation, merger, binding share exchange, transfer, liquidation or
dissolution. The Company shall file and mail the notice at least 15 days before such date. Failure to file or mail the notice or any defect in it shall not affect the validity of the transaction. 
 Section 10.16. Reorganization of Company; Special Distributions. 
 If the Company is a party to a transaction subject to Section 5.01 (other than a sale of all or substantially all of the assets of the Company in a transaction in which the holders of Common Stock immediately
prior to such transaction do not receive securities, cash or other assets of the Company or any other person) or a merger or binding share exchange which 

  

 54 

 
reclassifies or changes the outstanding Common Stock of the Company, the person obligated to deliver securities, cash or other assets upon conversion of
Securities shall enter into a supplemental indenture. If the issuer of securities deliverable upon conversion of Securities is an Affiliate of the successor Company, that issuer shall join in the supplemental indenture. 
 The supplemental indenture shall provide that after the effective time of the transaction, settlement of the Conversion Value will be based on the kind
and amount of cash, securities or other assets of the Company or another Person that a holder of Common Stock received in such transaction; provided that, for the avoidance of doubt, the Conversion Value will be paid in cash and at the
Company’s election, cash, Common Stock or a combination of cash and Common Stock in accordance with the terms of this Article 10. If the holders of Common Stock of the Company have the opportunity to elect the form of consideration to be
received in such transaction, then from and after the effective date of such transaction, the Securities shall be convertible into the consideration that the majority of the holders of Common Stock of the Company who made such an election received
in such transaction. The supplemental indenture shall provide for adjustments which shall be as nearly equivalent as may be practical to the adjustments provided for in this Article 10. The successor Company shall mail to Holders a notice
briefly describing the supplemental indenture. 
 If this Section applies, neither Section 10.06 nor 10.07 applies. If the Company makes
a distribution to all holders of its Common Stock of any of its assets, or debt securities or any rights, warrants or options to purchase securities of the Company that, but for the provisions of Section 10.08(c), would otherwise result in an
adjustment in the Conversion Rate pursuant to the provisions of Section 10.08, then, from and after the record date for determining the holders of Common Stock entitled to receive the distribution, a Holder of a Security that converts such
Security in accordance with the provisions of this Indenture shall upon such conversion be entitled to receive, in addition to the shares of Common Stock into which the Security is convertible, the kind and amount of securities, cash or other assets
comprising the distribution that such Holder would have received if such Holder had converted the Security immediately prior to the record date for determining the holders of Common Stock entitled to receive the distribution. 
 Section 10.17. Company Determination Final. 
 Any determination that the Company or the Board of Directors must make pursuant to Section 10.03, 10.06, 10.07, 10.08, 10.09, 10.10, 10.12, 10.13, 10.16 or 10.19 is conclusive. 
 Section 10.18. Trustee’s Adjustment Disclaimer. 
 The Trustee has no duty to determine when an adjustment under this Article 10 should be made, how it should be made or what it should be. The Trustee has no duty to determine whether a supplemental indenture under
Section 10.17 need be entered into or whether any provisions of any supplemental indenture are correct. The Trustee shall not be accountable for and makes no representation as to the validity or value of any securities or assets issued upon
conversion of Securities. The Trustee shall not be responsible for the Company’s failure to comply with this Article 10. Each Conversion Agent shall have the same protection under this Section 10.18 as the Trustee. 
  

 55 

 Section 10.19. Simultaneous Adjustments. 
 In the event that this Article 10 requires adjustments to the Conversion Rate under more than one of Sections 10.06(3), 10.07, 10.08 or 10.09, and the
record dates for the distributions giving rise to such adjustments shall occur on the same date, then such adjustments shall be made by applying, first, the provisions of Section 10.06(3), second, the provisions of Section 10.08, third,
the provisions of Section 10.09 and, fourth, the provisions of 10.07. 
 Section 10.20. Successive Adjustments. 
 After an adjustment to the Conversion Rate under this Article 10, any subsequent event requiring an adjustment under this Article 10 shall cause an
adjustment to the Conversion Rate as so adjusted. 
 Section 10.21. Rights Issued in Respect of Common Stock Issued Upon Conversion.

 Each share of Common Stock issued upon conversion of Securities pursuant to this Article 10 shall be entitled to receive the appropriate
number of rights (“Rights”), if any, and the certificates representing the Common Stock issued upon such conversion shall bear such legends, if any, in each case as may be provided by the terms of the Company’s Amended and
Restated Rights Agreement, dated as of October 21, 1999, between the Company and Mellon Investor Services LLC (formerly known as ChaseMellon Shareholder Services, L.L.C.), as Rights Agent, as amended, or any successor shareholder rights
agreement adopted by the Company, as the same may be amended from time to time (the “Rights Plan”), unless prior to any conversion, the Rights have separated from the Common Stock, in which case the Conversion Rate will be adjusted
at the time of separation as if the Company distributed to all holders of Common Stock, shares of the Company’s Capital Stock, evidences of indebtedness or assets as described in Section 10.07 or 10.08, subject to readjustment in the event
of the expiration, termination or redemption of such Rights. Notwithstanding anything to the contrary herein, the Conversion Rate shall not otherwise be adjusted as a result of any action under or with respect to the Rights Plan. 
 Section 10.22. Withholding Taxes for Adjustments in Conversion Rate. 
 If the Company pays withholding taxes on behalf of a Holder as a result of an adjustment to the Conversion Rate, the Company may, at its option, set off
such payments against payments of cash and Common Stock on the Securities. 
 Section 10.23. Exchange in Lieu of Conversion.

 (a) Notwithstanding anything in this Indenture to the contrary, when a Holder surrenders Securities for conversion, the Company may
direct the Conversion Agent to surrender, on or prior to the commencement of the relevant Conversion Reference Period, such Securities to a financial institution designated by the Company (which may not be an Affiliate of the Company; provided that,
for purposes of this Section 10.23, an “Affiliate” shall include any Person with direct or indirect ownership of 10% or more of the equity of the Company or the power, direct or indirect, to vote more than 10% of the securities having
ordinary voting power 

  

 56 

 
for the election of directors of the Company) (a “Financial Institution”) for exchange in lieu of conversion. The Company may, but is not
required to, pay customary and reasonable fees in connection with the exchange. 
 (b) In order to accept any such Securities
surrendered for conversion, the Financial Institution must agree to deliver, in exchange for such Securities, all cash or a combination of cash and shares of Common Stock equal to the Conversion Value, at the option of the Financial Institution.

 (c) By the Close of Business on the Trading Day immediately preceding the start of the Conversion Reference Period, the Company must
notify the Holder surrendering Securities for conversion that it has directed the Conversion Agent to surrender such Securities to a Financial Institution for exchange in lieu of conversion and such Financial Institution must notify the Conversion
Agent whether it will deliver, upon exchange, shares of Common Stock, cash or a specified combination thereof. 
 (d) If the Financial
Institution accepts any such Securities, it will deliver the appropriate number of shares of Common Stock, cash or a combination thereof, to the Conversion Agent and the Conversion Agent will deliver those shares of Common Stock or cash or
combination thereof, as the case may be, to the Holder. Any Securities exchanged by such Financial Institution will remain outstanding. 
 (e) If such Financial Institution agrees to accept any Securities for exchange but does not timely deliver the related consideration, or if such Financial Institution does not accept the Securities for exchange, the Company will, as
promptly as practical thereafter, but not later than the third Business Day following the determination of the Conversion Value, convert the Securities into cash and shares, if any, of Common Stock, pursuant to Section 10.02. 
 (f) The Company will not provide to the Financial Institution, directly or indirectly, any of such consideration delivered by the Financial Institution
in exchange for such Securities. 
 In no event will the Company’s designation of a Financial Institution pursuant to this
Section 10.23 require such Financial Institution to accept any Securities for exchange. The Company shall not be obligated to pay any consideration to, or otherwise enter into any agreement or arrangement with, a Financial Institution for or
with respect to such designation pursuant to this Section 10.23. 
 ARTICLE 11 
 PAYMENT OF INTEREST 
 Section 11.01.
Interest Payments. 
 Interest on any Security that is payable, and is punctually paid or duly provided for, on any applicable
Interest Payment Date shall be paid to the person in whose name that Security is registered at the Close of Business on the Regular Record Date or accrual date, as the case may be, for such interest at the office or agency of the Company maintained
for such purpose. Each installment of interest payable in cash on any Security shall be paid in same-day funds by 

  

 57 

 
transfer to an account maintained by the payee located inside the United States, if the Trustee shall have received proper wire transfer instructions from
such payee not later than the related Regular Record Date or accrual date, as the case may be, or, if no such instructions have been received by check mailed to the payee at its address set forth on the Registrar’s books. In the case of a
permanent Global Security, interest payable on any applicable payment date will be paid to the Depositary, with respect to that portion of such permanent Global Security held for its account by Cede & Co. for the purpose of permitting such
party to credit the interest received by it in respect of such permanent Global Security to the accounts of the beneficial owners thereof. 
 Section 11.02. Defaulted Interest. 
 Except as otherwise specified with respect to the Securities, any interest on any
Security that is payable, but is not punctually paid or duly provided for, within 30 days following any applicable payment date (herein called “Defaulted Interest”, which term shall include any accrued and unpaid interest that has
accrued on such defaulted amount in accordance with paragraph 1 of the Securities), shall forthwith cease to be payable to the registered Holder thereof on the relevant Regular Record Date or accrual date, as the case may be, by virtue of having
been such Holder, and such Defaulted Interest may be paid by the Company, at its election in each case, as provided in clause (1) or (2) below. All such Defaulted Interest shall be payable on the next Interest Payment Date. 
 (1) The Company may elect to make payment of any Defaulted Interest to the persons in whose names the Securities are registered at the
Close of Business on a special record date for the payment of such Defaulted Interest, which shall be fixed in the following manner. The Company shall notify the Trustee in writing of the amount of Defaulted Interest proposed to be paid on each
Security and the date of the proposed payment (which shall not be less than 20 days after such notice is received by the Trustee), and at the same time the Company shall deposit with the Trustee an amount of money equal to the aggregate amount
proposed to be paid in respect of such Defaulted Interest or shall make arrangements satisfactory to the Trustee for such deposit on or prior to the date of the proposed payment, such money when deposited to be held in trust for the benefit of the
persons entitled to such Defaulted Interest as in this clause provided. Thereupon the Trustee shall fix a special record date for the payment of such Defaulted Interest which shall be not more than 15 days and not less than 10 days prior to the date
of the proposed payment and not less than 10 days after the receipt by the Trustee of the notice of the proposed payment. The Trustee shall promptly notify the Company of such special record date and, in the name and at the expense of the Company,
shall cause notice of the proposed payment of such Defaulted Interest and the special record date therefor to be mailed, first-class postage prepaid, to each Holder at such Holder’s address as it appears on the list of Holders maintained
pursuant to Section 2.05 not less than 10 days prior to such special record date. Notice of the proposed payment of such Defaulted Interest and the special record date therefor having been mailed as aforesaid, such Defaulted Interest shall be
paid to the persons in whose names the Securities are registered at the Close of Business on such special record date and shall no longer be payable pursuant to the following clause (2). 
  

 58 

 (2) The Company may make payment of any Defaulted Interest on the Securities in any other
lawful manner not inconsistent with the requirements of any securities exchange on which such Securities may be listed, and upon such notice as may be required by such exchange, if, after notice given by the Company to the Trustee of the proposed
payment pursuant to this clause, such manner of payment shall be deemed practicable by the Trustee. 
 Section 11.03. Interest Rights
Preserved. 
 Subject to the foregoing provisions of this Article 11 and Section 2.06, each Security delivered under this Indenture
upon registration of transfer of or in exchange for or in lieu of any other Security shall carry the rights to interest accrued and unpaid, and to accrue, which were carried by such other Security. 
 ARTICLE 12 
 MISCELLANEOUS

 Section 12.01. Trust Indenture Act Controls. 
 If any provision of this Indenture limits, qualifies, or conflicts with another provision which is required to be included in this Indenture by the TIA, the required provision shall control. 
 Section 12.02. Notices; Address of Agency. 
 (i) Other than as set forth in Section 10.01, any request, demand, authorization, notice, waiver, consent or communication shall be in writing and delivered in person or mailed by first-class mail, postage prepaid, addressed as follows
or transmitted by facsimile transmission (confirmed by guaranteed overnight courier) to the following facsimile numbers: 
 if to the
Company: 
 Gilead Sciences, Inc. 
 333 Lakeside Drive 
 Foster City, California 94404 
 Telephone No.: (650) 574-3000 
 Facsimile No.: (650) 578-9264 
 Attention: Treasurer 
  

 59 

 with a copy to: 
 Latham & Watkins LLP 
 633 West Fifth Street 
 Suite 4000 
 Los Angeles, CA 90071 
 Telephone No.: (213) 485-1234 
 Facsimile No.: (213) 891-8763 
 Attention: Gregory Rodgers, Esq. 
 if to the Trustee: 
 Wells Fargo Bank, National Association 
 213 Court Street 
 Middletown, CT 06457 
 Telephone No.: (860) 704-6217 
 Facsimile No.: (860) 704-6219 
 Attention: Joe O’Donnell, Vice President 
 The Company or the Trustee by notice given to the other in
the manner provided above may designate additional or different addresses for subsequent notices or communications. 
 Any notice or
communication given to a Holder shall be mailed to the Holder, by first-class mail, postage prepaid, at the Holder’s address as it appears on the registration books of the Registrar and shall be sufficiently given if so mailed within the time
prescribed. 
 Failure to mail a notice or communication to a Holder or any defect in it shall not affect its sufficiency with respect to
other Holders. If a notice or communication is mailed in the manner provided above, it is duly given, whether or not received by the addressee. 
 If the Company mails a notice or communication to the Holders, it shall mail a copy to the Trustee and each Registrar, Paying Agent, Conversion Agent or co-registrar. 
 (ii) Any request, demand, authorization, notice, waiver, consent or communication to be provided in connection with Section 10.02 shall be in
writing and delivered in person or transmitted by facsimile transmission (confirmed by guaranteed overnight courier) to the following facsimile numbers or via e-mail to the account or accounts specified by the Company by written notice to the
Trustee: 
 if to the Company: 
 Gilead Sciences, Inc. 
 333 Lakeside Drive 
 Foster City, California 94404 
 Telephone No.: (650) 574-3000 
 Facsimile No.: (650) 578-9264 
 Attention: Treasurer 
  

 60 

 with a copy to: 
 Latham & Watkins LLP 
 633 West Fifth Street 
 Suite 4000 
 Los Angeles, CA 90071 
 Telephone No.: (213) 485-1234 
 Facsimile No.: (213) 891-8763 
 Attention: Gregory Rodgers, Esq. 
 and 
 Merrill Lynch International 
 Merrill Lynch Financial Centre 
 2 King Edward Street 
 London EC1A 1HQ 
 Telephone No.: 44 207 995 3769 
 Facsimile No.: 44 207 995 2004 
 Attention: Manager, Fixed Income Settlements 
 Any notice party set forth in this Section 12.02(b) by notice given to the others in the manner provided above may designate additional or different
addresses for subsequent notices or communications, including e-mail addresses. 
 Section 12.03. Communication by Holders with Other
Holders. 
 Holders may communicate pursuant to TIA Section 312(b) with other Holders with respect to their rights under this
Indenture or the Securities. The Company, the Trustee, the Registrar, the Paying Agent, the Conversion Agent and anyone else shall have the protection of TIA Section 312(c). 
 Section 12.04. Certificate and Opinion as to Conditions Precedent. 
 Upon any request or application by the Company to the Trustee to take any action under this Indenture, the Company shall furnish to the Trustee: 
 (1) an Officers’ Certificate stating that, in the opinion of the signers, all conditions precedent, if any, provided for in this
Indenture relating to the proposed action have been complied with; and 
 (2) an Opinion of Counsel stating that, in the
opinion of such counsel, all such conditions precedent have been complied with. 
 Section 12.05. Statements Required in Certificate or
Opinion. 
 Unless the Trustee agrees, in its sole discretion, to accept a different form or format, each Officers’ Certificate or
Opinion of Counsel with respect to compliance with a covenant or condition provided for in this Indenture shall include: 
 (1) a statement that each person making such Officers’ Certificate or Opinion of Counsel has read such covenant or condition; 
  

 61 

 (2) a brief statement as to the nature and scope of the examination or investigation upon
which the statements or opinions contained in such Officers’ Certificate or Opinion of Counsel are based; 
 (3) a
statement that, in the opinion of each such person, he has made such examination or investigation as is necessary to enable such person to express an informed opinion as to whether or not such covenant or condition has been complied with; and

 (4) a statement that, in the opinion of such person, such covenant or condition has been complied with. 
 Section 12.06. Separability Clause. 
 In case any provision in this Indenture or in the Securities shall be invalid, illegal or unenforceable, the validity, legality and enforceability of the remaining provisions shall not in any way be affected or impaired thereby. 

Section 12.07. Rules by Trustee, Paying Agent, Conversion Agent and Registrar. 
 The Trustee may make reasonable rules for action by or a meeting of Holders. The Registrar, Conversion Agent and the Paying Agent may make reasonable
rules for their functions. 
 Section 12.08. Calculations. 
 The calculation of the Conversion Value, Conversion Date, Volume Weighted Average Price, Conversion Reference Period, Change in Control Purchase Price,
Conversion Rate, Closing Price of the Common Stock, Required Cash Amount, Trading Price, the number of shares, if any, to be issued upon conversion and, except as otherwise provided in this Indenture, each other calculation to be made hereunder
shall be the obligation of the Company. All calculations made by the Company as contemplated pursuant to this Section 12.08 shall be in good faith and final and binding on the Company and the Holders absent manifest error. The Company will
provide a schedule of the calculations to the Trustee and the Trustee is entitled to rely upon the accuracy of the calculations without independent verification. 
 Section 12.09. Legal Holidays. 
 A “Legal Holiday” is any day other than a Business
Day. If any specified date (including a date for giving notice) is a Legal Holiday, the action shall be taken on the next succeeding day that is not a Legal Holiday, and, if the action to be taken on such date is a payment in respect of the
Securities, interest shall not accrue for the intervening period. 
  

 62 

 Section 12.10. Governing Law. 
 THE LAWS OF THE STATE OF NEW YORK SHALL GOVERN THIS INDENTURE AND THE SECURITIES. 
 Section 12.11. No Recourse Against Others. 
 A director, officer, employee or stockholder, as such, of the Company shall not have any liability for any obligations of the Company under the Securities or this Indenture or for any claim based on, in respect of or by reason of such
obligations or their creation. By accepting a Security, each Holder shall waive and release all such liability. The waiver and release shall be part of the consideration for the issue of the Securities. 
 Section 12.12. Successors. 
 All
agreements of the Company in this Indenture and the Securities shall bind its successor. All agreements of the Trustee in this Indenture shall bind its successor. 
 Section 12.13. Multiple Originals. 
 The parties may sign any number of copies of this Indenture.
Each signed copy shall be an original, but all of them together represent the same agreement. One signed copy is enough to prove this Indenture. 
 (Signature Pages Follow) 
  

 63 

 IN WITNESS WHEREOF, the undersigned, being duly authorized, have executed this Indenture on behalf of the
respective parties hereto as of the date first above written. 
  

					
	GILEAD SCIENCES, INC.
		
	By:	 	/s/ JOHN F. MILLIGAN
		 	Name: 	 	John F. Milligan, Ph.D.
		 	Title:	 	 Executive Vice President and
 Chief Financial
Officer

  

					
	 WELLS FARGO BANK, NATIONAL ASSOCIATION,
as Trustee

		
	By:	 	/s/ FRANK McDONALD
		 	Name: 	 	Frank McDonald
		 	Title:	 	Vice President

  

 64 

 EXHIBIT A 
 [FORM OF FACE OF SECURITY] 
 UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY
TRUST COMPANY TO THE ISSUER OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE
DEPOSITORY TRUST COMPANY (AND ANY PAYMENT HEREON IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE
BY OR TO ANY PERSON IS WRONGFUL SINCE THE REGISTERED OWNER HEREOF,             1, HAS AN INTEREST HEREIN. 
 TRANSFERS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS IN WHOLE, BUT
NOT IN PART, TO NOMINEES OF THE DEPOSITORY TRUST COMPANY, OR TO A SUCCESSOR THEREOF OR SUCH SUCCESSOR’S NOMINEE AND TRANSFERS OF PORTIONS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS MADE IN ACCORDANCE WITH THE RESTRICTIONS SET FORTH
IN ARTICLE TWO OF THE INDENTURE REFERRED TO ON THE REVERSE HEREOF.2 
 THE NOTES AND THE SHARES OF COMMON STOCK ISSUABLE UPON CONVERSION OF THIS NOTE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE SECURITIES
ACT), OR ANY STATE SECURITIES LAWS. NEITHER THIS NOTE, THE SHARES OF COMMON STOCK ISSUABLE UPON CONVERSION OF THIS NOTE NOR ANY INTEREST OR PARTICIPATION HEREIN OR THEREIN MAY BE REOFFERED, SOLD, ASSIGNED, TRANSFERRED, PLEDGED, ENCUMBERED OR
OTHERWISE DISPOSED OF IN THE ABSENCE OF SUCH REGISTRATION OR UNLESS SUCH TRANSACTION IS EXEMPT FROM, OR NOT SUBJECT TO, REGISTRATION.3 
 BY ITS ACQUISITION HEREOF, THE HOLDER AGREES TO OFFER, SELL OR OTHERWISE TRANSFER SUCH NOTE PRIOR TO THE DATE WHICH IS TWO YEARS
AFTER THE LATER OF THE LAST ORIGINAL ISSUE DATE HEREOF AND THE LAST DATE ON WHICH THE COMPANY OR ANY AFFILIATE OF THE COMPANY WAS THE OWNER OF THIS NOTE (OR ANY PREDECESSOR OF THIS NOTE) ONLY (A) TO THE COMPANY OR ANY SUBSIDIARY THEREOF,
(B) PURSUANT TO A REGISTRATION STATEMENT WHICH HAS BEEN DECLARED EFFECTIVE UNDER THE SECURITIES ACT, (C) TO A PERSON IT REASONABLY BELIEVES IS A QUALIFIED INSTITUTIONAL BUYER AS DEFINED IN RULE 144A THAT PURCHASES FOR ITS 

	1	Cede &Co. or its successor for Global Securities. 

  

	2	This paragraph should be included if the Security is a Global Security. 

  

	3	This paragraph should be included only if the Security is a Restricted Security. 

  

 A-1 

 OWN ACCOUNT OR FOR THE ACCOUNT OF A QUALIFIED INSTITUTIONAL BUYER TO WHOM NOTICE IS GIVEN THAT THE TRANSFER IS BEING MADE
IN RELIANCE ON RULE 144A, (D) PURSUANT TO ANOTHER AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT, SUBJECT TO THE COMPANY’S AND THE TRUSTEE’S RIGHT PRIOR TO ANY SUCH OFFER, SALE OR TRANSFER PURSUANT TO
CLAUSE (D) TO REQUIRE THE DELIVERY OF AN OPINION OF COUNSEL, CERTIFICATIONS AND/OR OTHER INFORMATION SATISFACTORY TO EACH OF THEM, AND IN EACH OF THE FOREGOING CASES, TO REQUIRE THAT A CERTIFICATE OF TRANSFER IN THE FORM APPEARING ON THE OTHER
SIDE OF THIS NOTE IS COMPLETED AND DELIVERED BY THE TRANSFEROR TO THE TRUSTEE. THIS LEGEND WILL BE REMOVED UPON THE REQUEST OF THE HOLDER AFTER THE RESALE RESTRICTION TERMINATION DATE.4 

	4	This paragraph should be included only if the Security is a Restricted Security.

  

 A-2 

 GILEAD SCIENCES, INC. 
 0.50% Convertible Senior Note due 2011 
  

			
	 No.
	 	CUSIP: 375558AE3
	 Issue Date:
	 	
	 Principal Amount:
	 	

 GILEAD SCIENCES, INC., a Delaware Corporation, promises to pay to Cede & Co. or
registered assigns, the Principal Amount of                                  on
May 1, 2011. 
 This Security shall bear cash interest at the rate of 0.50% per annum. This Security is convertible as specified on
the other side of this Security. 
 Additional provisions of this Security are set forth on the other side of this Security. 
  

 A-3 

			
	 GILEAD SCIENCES, INC.

		
	By:	 	  
		 	 Name:

		 	 Title:

  

 A-4 

			
	 TRUSTEE’S CERTIFICATE OF
 AUTHENTICATION

	
	 Wells Fargo Bank, National Association,
 as Trustee, certifies that this
 is one of the Securities referred
 to in the within-mentioned Indenture.

		
	 By:
	 	  
		 	 Authorized Officer

  

 A-5 

 [FORM OF REVERSE SIDE OF NOTE] 
 0.50% Convertible Senior Note due 2011 
  

	1.	Interest. 

 This Security shall bear cash interest at the
rate of 0.50% per annum. Interest on this Security shall accrue from the Issue Date, or from the most recent date to which interest has been paid or provided for. Interest shall be payable semiannually in arrears on May 1 and
November 1 of each year, beginning on November 1, 2006, to the holders of record of Securities at the Close of Business on the April 15 or October 15 immediately preceding such Interest Payment Date. Each payment of cash interest
on this Security shall include interest accrued for the period commencing on and including the immediately preceding Interest Payment Date (or, if none, the scheduled original Issue Date) through the day before the applicable Interest Payment Date
or purchase date. Any payment required to be made on any day that is not a Business Day shall be made on the next succeeding Business Day. Interest shall be calculated using a 360-day year composed of twelve 30-day months. Interest shall cease to
accrue on this Security upon its Stated Maturity, conversion or purchase by the Company at the option of the Holder upon a Change in Control in accordance with paragraph 5 hereof. 
 If the Principal Amount hereof or any portion of such Principal Amount is not paid when due (whether upon acceleration pursuant to Section 6.02 of
the Indenture, upon the date set for payment of the Change in Control Purchase Price pursuant to paragraph 5 hereof or upon the Stated Maturity of this Security) or if interest (including Additional Interest, if any) due hereon or any portion of
such interest is not paid when due in accordance with paragraph 5 or 7 hereof, then in each such case the overdue amount shall, to the extent permitted by law, bear interest at the rate of 0.50% per annum, compounded semiannually, which
interest shall accrue from the date such overdue amount was originally due to the date payment of such amount, including interest thereon, has been made or duly provided for. All such interest shall be payable on the next Interest Payment Date.

  

	2.	Method of Payment. 

 Subject to the terms and conditions of
the Indenture, the Company will make payments in respect of Change in Control Purchase Prices and at Stated Maturity to Holders who surrender Securities to a Paying Agent to collect such payments in respect of the Securities. The Company will pay
any cash amounts in money of the United States that at the time of payment is legal tender for payment of public and private debts. However, the Company may make such cash payments by check payable in such money. 
  

	3.	Paying Agent, Conversion Agent and Registrar. 

 Initially,
Wells Fargo Bank, National Association, a national banking association (the “Trustee”), will act as Paying Agent, Conversion Agent and Registrar. The Company may appoint and change any Paying Agent, Conversion Agent, Registrar or
co-registrar without notice, other than notice to the Trustee. The Company or any of its Subsidiaries or any of their 

  

 A-6 

 
Affiliates may act as Paying Agent, Conversion Agent, Registrar or co-registrar. The Company may maintain deposit accounts and conduct other banking
transactions with the Trustee in the normal course of business. 
  

	4.	Indenture. 

 The Company issued the Securities under an
Indenture dated as of April 25, 2006 (the “Indenture”), between the Company and the Trustee. The terms of the Securities include those stated in the Indenture and those made part of the Indenture by reference to the Trust
Indenture Act of 1939, as in effect from time to time (the “TIA”). Capitalized terms used herein and not defined herein have the meanings ascribed thereto in the Indenture. The Securities are subject to all such terms, and Holders
are referred to the Indenture for a statement of those terms. 
 The Securities are senior unsecured obligations of the Company limited to
$650,000,000 aggregate Principal Amount (subject to Section 2.07 of the Indenture). The Indenture does not limit other indebtedness of the Company, secured or unsecured. 
  

	5.	Purchase by the Company at the Option of the Holder upon a Change in Control. 

 At the option of the Holder and subject to the terms and conditions of the Indenture, the Company shall become obligated to purchase the Securities held by such Holder no later than 35 Business Days after the
occurrence of a Change in Control of the Company for a Change in Control Purchase Price equal to the Principal Amount of the Securities to be purchased, plus accrued and unpaid interest to, but excluding, the Change in Control Purchase Date, unless
the Change in Control Purchase Date is after a Regular Record Date and on or prior to the Interest Payment Date to which it relates, in which case interest accrued to the Interest Payment Date will be paid to Holders of the Securities as of the
preceding Regular Record Date, which Change in Control Purchase Price shall be paid in cash. 
 In addition to the Change in Control Purchase
Price payable with respect to all Securities or portions thereof to be purchased as of the Change in Control Purchase Date, the Holders of such Securities (or portions thereof) shall be entitled to receive accrued and unpaid interest with respect
thereto, which shall be paid at the same time as the Change in Control Purchase Price. 
 Holders have the right to withdraw any Change in
Control Purchase Notice by delivering to the Paying Agent a written notice of withdrawal in accordance with the provisions of the Indenture. 
 If cash (and/or securities if permitted under the Indenture) sufficient to pay the Change in Control Purchase Price, of, together with any accrued and unpaid interest with respect to, all Securities or portions thereof to be purchased as of
the Change in Control Purchase Date is deposited with the Paying Agent on or prior to the third Business Day following the Change in Control Purchase Date, interest shall cease to accrue on such Securities (or portions thereof) immediately after
such Change in Control Purchase Date whether or not the Security is delivered to the Paying Agent, and the Holder thereof shall have no other rights as such (other than the 

  

 A-7 

 
right to receive the Change in Control Purchase Price and accrued and unpaid interest upon surrender of such Security). 
  

	6.	Conversion. 

 A Holder of a Security may convert such
Security into cash and, at the option of the Company, shares of Common Stock of the Company before the Close of Business on May 1, 2011, if at least one of the following conditions is satisfied: 
 (a) during any calendar quarter commencing at any time after September 30, 2006, and only during such calendar quarter, if the Closing Price of the
Common Stock for at least 20 Trading Days in the period of 30 consecutive Trading Days ending on the last Trading Day of the preceding calendar quarter exceeds 130% of the Conversion Price per share on that 30th Trading Day on the last day of such
preceding calendar quarter. The Conversion Agent will determine on the Company’s behalf at the beginning of each calendar quarter commencing at any time after September 30, 2006 through and including the calendar quarter ending
March 31, 2011, whether the Securities are convertible as a result of the price of the Common Stock and notify the Company and the Trustee. Upon determining that the Holders are entitled to convert their Securities in accordance with the
provisions described in the Indenture on account of this subsection (a), the Company will promptly (1) issue a press release and use its reasonable efforts to post such information on its website or otherwise publicly disclose this information
or (2) provide notice to the Holders in a manner contemplated by the Indenture, including through the facilities of DTC; 
 (b) the
Company elects to distribute to all holders of Common Stock (i) rights or warrants entitling them to subscribe for or purchase, for a period expiring within 60 days after the record date for such distribution, Common Stock at less than the
Average Closing Prices of the Common Stock, or (ii) cash, debt securities (or other evidence of Indebtedness) or other assets (excluding dividends or distributions described in Sections 10.06(1), 10.06(2) and 10.06(3) of the Indenture), which
distribution, together with all other distributions within the preceding 12 months, has a per share value exceeding 15% of the Average Closing Price of the Common Stock; or 
 (c) if a Change in Control occurs or if the Company is a party to a consolidation, merger, binding share exchange, transfer or lease of all or
substantially all of the Company’s assets, pursuant to which the Common Stock would be converted into cash, securities or other assets, at any time from or after the date which is 15 days prior to the effective time of the transaction until 35
days after the actual date of such transaction (or, if the transaction also constitutes a Change in Control, until the Change in Control Purchase Date). After the effective time of the transaction, settlement of the Conversion Value will be based on
the kind and amount of cash, securities or other assets of the Company or another Person that a holder of Common Stock received in such transaction; provided that, for the avoidance of doubt, the Conversion Value will be paid in cash and at
the Company’s election, cash, Common Stock or a combination of cash and Common Stock in accordance with the terms of the Indenture. In the event holders of Common Stock have the opportunity to elect the form of consideration to be received in
such transaction, then from and after the effective date of such transaction, the Securities shall be 

  

 A-8 

 
convertible into the consideration that a majority of the holders of Common Stock who made such an election received in such transaction. The Company will
notify Holders and the Trustee as promptly as practicable following the date the Company publicly announces such transaction (but in no event less than 15 days prior to the anticipated effective date of such transaction). 
 If the Company makes a distribution described in subsection (b), the Company must notify Holders at least 20 days prior to the Ex-Dividend Date for such
distribution. Once the Company has given such notice, Holders may surrender their Securities for conversion at any time until the earlier of the Close of Business on the Business Day prior to the Ex-Dividend Date or the Company’s announcement
that such distribution will not take place, even if the Securities are not convertible at that time. No adjustment to the ability of Holders to convert will be made if Holders are entitled to participate in the distribution without conversion.

 In the case of a Change in Control, (i) the Conversion Rate will be adjusted as described in Section 10.11 of the Indenture and
(ii) the Holder can require the Company to purchase all or a portion of its Securities described in paragraph 5. 
 A Security in
respect of which a Holder has delivered a Change in Control Purchase Notice exercising the option of such Holder to require the Company to purchase such Security may be converted only if such notice of exercise is withdrawn in accordance with the
terms of the Indenture. 
 The Initial Conversion Rate is 12.9024 shares of Common Stock per $1,000 Principal Amount, subject to adjustment
in certain events described in the Indenture. The Company will deliver cash or a check in lieu of any fractional share of Common Stock. 
 Notwithstanding anything herein to the contrary, Holders may surrender the Securities for conversion at any time on or after April 1, 2011, until the Close of Business on the Business Day immediately preceding the Maturity Date.

 Accrued and unpaid interest will not be paid in cash on Securities that are converted but will be paid in the manner provided in the
following paragraph; provided, however, that Securities surrendered for conversion during the period, in the case of interest, from the Close of Business on any Regular Record Date next preceding any Interest Payment Date to the opening of
business on such Interest Payment Date, shall be entitled to receive such semiannual interest payable on such Securities on the corresponding Interest Payment Date and Securities surrendered for conversion during such periods must be accompanied by
payment of an amount equal to the interest with respect thereto that the registered Holder is to receive; provided that no such payment need be made (i) in connection with any conversion following the Regular Record Date immediately
preceding the final Interest Payment Date; (ii) if the Company has specified a Change in Control Purchase Date that is after a Record Date and on or prior to the corresponding Interest Payment Date; or (iii) to the extent of Defaulted
Interest, if any Defaulted Interest exists at the time of conversion with respect to such Security. 
 A Holder may convert a portion of a
Security if the Principal Amount of such portion is $1,000 or an integral multiple of $1,000. No payment or adjustment will be made for dividends 

  

 A-9 

 
on the Common Stock except as provided in the Indenture. On conversion of a Security, a Holder will not receive, except as described herein, any cash payment
representing accrued interest. Instead, accrued interest will be deemed paid by the cash and/or shares of Common Stock received by the Holder on conversion. Delivery to the holder of such cash and/or shares will be deemed to satisfy the
Company’s obligation to pay (i) the Principal Amount of the Security and (ii) accrued and unpaid interest, and accrued interest with respect to the converted Security shall not be cancelled, extinguished or forfeited, but rather shall
be deemed to be paid in full. 
 The Company will not adjust the Conversion Rate to account for accrued interest. 
 To convert a Security that is represented by a Global Security, a Holder must convert by book-entry transfer to the Conversion Agent through the
facilities of the DTC. To convert a Security that is represented by a Certificated Security, a Holder must (1) complete and manually sign the conversion notice below and deliver such notice to the Conversion Agent, (2) surrender the
Security to the Conversion Agent, (3) furnish appropriate endorsements and transfer documents if required by the Conversion Agent, the Company or the Trustee and (4) pay all transfer or similar tax, if required. 
 The Conversion Rate will be adjusted for dividends or distributions on Common Stock payable in Common Stock or other Capital Stock; subdivisions,
combinations or certain reclassifications of Common Stock; distributions to all holders of Common Stock of certain rights to purchase Common Stock for a period expiring within 60 days of the record date for such distribution at less than the Closing
Price of the Common Stock at the Time of Determination; distributions to such holders of assets (including shares of Capital Stock of a Subsidiary) or debt securities of the Company or certain rights to purchase securities of the Company; cash
dividends or cash distributions; and distributions in respect of a tender offer or exchange offer of the Common Stock. However, no adjustment need be made if Holders may participate in the transaction or in certain other cases. 
  

	7.	Defaulted Interest. 

 Except as otherwise specified with
respect to the Securities, any Defaulted Interest on any Security shall forthwith cease to be payable to the registered Holder thereof on the relevant Regular Record Date or accrual date, as the case may be, by virtue of having been such Holder, and
such Defaulted Interest may be paid by the Company as provided for in Section 11.02 of the Indenture. 
  

	8.	Denominations; Transfer; Exchange. 

 The Securities are in
fully registered form, without coupons, in denominations of $1,000 of Principal Amount and integral multiples of $1,000. A Holder may transfer or exchange Securities in accordance with the Indenture. The Registrar may require a Holder, among other
things, to furnish appropriate endorsements and transfer documents and to pay any taxes and fees required by law or permitted by the Indenture. The Registrar need not register the transfer or exchange of any Securities in respect of which a Change
in Control Purchase Notice has been 

  

 A-10 

 
given and not withdrawn (except, in the case of a Security to be purchased in part, the portion of the Security not to be purchased). 
  

	9.	Persons Deemed Owners. 

 The registered Holder of this
Security may be treated as the owner of this Security for all purposes. 
  

	10.	Unclaimed Money or Securities. 

 The Trustee and the Paying
Agent shall return to the Company upon written request any money or securities held by them for the payment of any amount with respect to the Securities that remains unclaimed for two years, subject to applicable unclaimed property laws. After
return to the Company, Holders entitled to the money or securities must look to the Company for payment as general creditors unless an applicable abandoned property law designates another person. 
  

	11.	Amendment; Waiver. 

 Subject to certain exceptions set
forth in the Indenture, (i) the Indenture or the Securities may be amended with the written consent of the Holders of at least a majority in aggregate Principal Amount of the Securities at the time outstanding and (ii) certain Defaults may
be waived with the written consent of the Holders of a majority in aggregate Principal Amount of the Securities at the time outstanding. Subject to certain exceptions set forth in the Indenture, without the consent of any Holder, the Company and the
Trustee may amend the Indenture or the Securities to cure any ambiguity, omission, defect or inconsistency, or to comply with Article 5 or Section 10.16 of the Indenture, to secure the Company’s obligations under this Security or to add to
the Company’s covenants for the benefit of the Holders or to surrender any right or power conferred, or to comply with any requirement of the SEC in connection with the qualification of the Indenture under the TIA, or as necessary in connection
with the registration of the Securities under the Securities Act or to make any change that does not adversely affect the rights of any Holders. 
  

	12.	Defaults and Remedies. 

 Under the Indenture, Events of
Default include: (1) the Company defaults in the payment of the Principal Amount or Change in Control Purchase Price, when the same becomes due and payable; (2) the Company defaults in payment of any interest due on the Securities, which default
continues for 30 days; (3) the Company fails to comply with any of its agreements in the Securities or the Indenture (other than those referred to in clauses (1) and (2) above) and such failure continues for 60 days after receipt by the Company of a
Notice of Default; (4) the (a) failure of the Company to make any payment by the end of any applicable grace period after maturity of Indebtedness in an amount in excess of $100.0 million, or (b) acceleration of Indebtedness in an
amount in excess of $100.0 million because of a default with respect to such Indebtedness without such Indebtedness having been discharged or such acceleration having been cured, waived, rescinded or annulled, subject to notice and lapse of time;
provided, 

  

 A-11 

 
however, that if any such failure or acceleration referred to in (a) or (b) above shall cease or be cured, waived, rescinded or annulled,
then the Event of Default by reason thereof shall be deemed not to have occurred; and (5) certain events of bankruptcy or insolvency. If an Event of Default occurs and is continuing, the Trustee, or the Holders of at least 25% in aggregate
Principal Amount of the Securities at the time outstanding, may declare the Principal Amount through the date of such declaration, and any accrued and unpaid interest through the date of such declaration, on all the Securities to be due and payable
immediately. Certain events of bankruptcy or insolvency are Events of Default which will result in the Principal Amount on the Securities, and any accrued and unpaid interest through the occurrence of such event, becoming due and payable immediately
upon the occurrence of such Events of Default. 
 Holders may not enforce the Indenture or the Securities except as provided in the
Indenture. The Trustee may refuse to enforce the Indenture or the Securities unless it receives indemnity or security reasonably satisfactory to it. Subject to certain limitations, Holders of a majority in aggregate Principal Amount of the
Securities at the time outstanding may direct the Trustee in its exercise of any trust or power. The Trustee may withhold from Holders notice of any continuing Default (except a Default in payment of amounts specified in clause (1) or
(2) above) if it determines that withholding notice is in their interests. 
  

	13.	Trustee Dealings with the Company. 

 Subject to certain
limitations imposed by the TIA, the Trustee under the Indenture, in its individual or any other capacity, may become the owner or pledgee of Securities and may otherwise deal with and collect obligations owed to it by the Company or its Affiliates
and may otherwise deal with the Company or its Affiliates with the same rights it would have if it were not Trustee. 
  

	14.	No Recourse Against Others. 

 A director, officer, employee
or stockholder, as such, of the Company shall not have any liability for any obligations of the Company under the Securities or the Indenture or for any claim based on, in respect of or by reason of such obligations or their creation. By accepting a
Security, each Holder waives and releases all such liability. The waiver and release are part of the consideration for the issue of the Securities. 
  

	15.	Authentication. 

 This Security shall not be valid until an
authorized officer of the Trustee manually signs the Trustee’s Certificate of Authentication on the other side of this Security. 
  

	16.	Abbreviations. 

 Customary abbreviations may be used in the
name of a Holder or an assignee, such as TEN COM (=tenants in common), TEN ENT (=tenants by the entireties), JT TEN (=joint tenants with right of survivorship and not as tenants in common), CUST (=custodian), and U/G/M/A (=Uniform Gift to Minors
Act). 
  

 A-12 

	17.	GOVERNING LAW. 

 THE LAW OF THE STATE OF NEW YORK SHALL
GOVERN THE INDENTURE AND THIS SECURITY. 
  

 The Company will furnish to any Holder upon written request and without charge a copy of the Indenture which has in it the text of this Security in larger type. Requests may be made to: 
 Gilead Sciences, Inc. 
 333 Lakeside Drive

 Foster City, California 94404 
 Telephone No.: (650) 574-3000 
 Facsimile No.: (650) 578-9264 
 Attention: Treasurer 
  

 A-13 

 ASSIGNMENT FORM 
 To assign this Security, fill in the form below: 
 I or we assign and transfer this Security to: 
                                       
                                        
                                        
                                        
                                        
                                        
                    
                                       
                                        
                                        
                                        
                                        
                                        
                    
 (Insert assignee’s soc. sec. or
tax ID no.) 
                                       
                                        
                                        
                                        
                                        
                                        
                    
                                       
                                        
                                        
                                        
                                        
                                        
                    
                                       
                                        
                                        
                                        
                                        
                                        
                    
 (Print or type assignee’s name, address and zip code) 
 and irrevocably appoint 
                                      agent to
transfer this Security on the books of the Company. The agent may substitute another to act for him. 
 CONVERSION NOTICE 

To convert this Security into Common Stock of the Company, check the box:  ̈ 
 To convert only part of this Security, state the Principal Amount to be converted (which must be $1,000 or an integral
multiple of $1,000): 
 $                                     
 If you want the stock certificate made out in another person’s name, fill in the form below: 
                                       
                                        
                                        
                                        
                                        
                                        
                    
                                       
                                        
                                        
                                        
                                        
                                        
                    
 (Insert other person’s soc. sec.
or tax ID no.) 
                                       
                                        
                                        
                                        
                                        
                                        
                    
                                       
                                        
                                        
                                        
                                        
                                        
                    
                                       
                                        
                                        
                                        
                                        
                                        
                    
 (Print or type other person’s name, address and zip code) 
  

									
					
	Date:	 	  	 		 	 Your Signature:
	 	  

                                       
                                        
                                        
                                        
                                        
                                        
                    
                                       
                                        
                                        
                                        
                                        
                                        
                    
 (Sign exactly as your name appears on
the other side of this Security) 
  

 A-14

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