Document:

EX-10.2

 Exhibit 10.2 
 INFRAREDX, INC. 
 AMENDED AND RESTATED

 1999 STOCK OPTION AND INCENTIVE PLAN 

1. Purpose and Eligibility 
 The purpose of this 1999 Amended and Restated Stock Option and Incentive Plan (the “Plan”) of InfraReDx, Inc. (the “Company”) is to provide stock options and other equity
interests in the Company (each an “Award”) to employees, officers, directors, consultants and advisors of the Company and its Subsidiaries, all of whom are eligible to receive Awards under the Plan. Any person to whom an Award has
been granted under the Plan is called a “Participant”. Additional definitions are contained in Section 8. 
 2.
Administration 
 a. Administration by Board of Directors. The Plan will be administered by the Board of Directors
of the Company (the “Board”). The Board, in its sole discretion, shall have the authority: 
 (i) To determine
from time to time which of the persons eligible under the Plan shall be granted Awards; when and how each Award shall be granted; what type or combination of types of Award shall be granted; the provisions of each Award granted (which need not be
identical), including the time or times when a person shall be permitted to receive Common Stock pursuant to an Award; and the number of shares of Common Stock with respect to which an Award shall be granted to each such person. 

(ii) To construe and interpret the Plan and Awards granted under it, and to establish, amend and revoke rules and regulations for its
administration. The Board, in the exercise of this power, may correct any defect, omission or inconsistency in the Plan or in any Award agreement, in a manner and to the extent it shall deem necessary or expedient to make the Plan fully effective.

 (iii) To effect, at any time and from time to time, with the consent of any adversely affected Participant, (1) the
reduction of the exercise price of any outstanding Option under the Plan, (2) the cancellation of any outstanding Option under the Plan and the grant in substitution therefor of (A) a new Option under the Plan or another equity plan of the
Company covering the same or a different number of shares of Common Stock, (B) a Restricted Stock Award (including a stock bonus), (C) a stock appreciation right, (D) cash and/or (E) other valuable consideration (as determined by
the Board, in its sole discretion), or (3) any other action that is treated as a repricing under generally accepted accounting principles. 
 (iv) To amend the Plan or an Award as provided in this Plan. 
 (v) To terminate or
suspend the Plan as provided in this Plan. 

  
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 (vi) Generally, to exercise such powers and to perform such acts as the Board deems
necessary or expedient to promote the best interests of the Company and that are not in conflict with the provisions of the Plan. 
 All decisions by the Board shall be final and binding on all interested persons. Neither the Company nor any member of the Board shall be liable for any action or determination relating to the Plan.

 b. Appointment of Committees. To the extent permitted by applicable law, the Board may delegate any or all of its
powers under the Plan to one or more committees or subcommittees of the Board (a “Committee”). All references in the Plan to the “Board” shall mean such Committee or the Board. 

c. Delegation to Executive Officers. To the extent permitted by applicable law, the Board may delegate to one or more executive
officers of the Company the power to grant Awards and exercise such other powers under the Plan as the Board may determine, provided that the Board shall fix the maximum number of Awards to be granted and the maximum number of shares issuable
to any one Participant pursuant to Awards granted by such executive officers. An executive officer may not designate himself or herself as the recipient of an Award hereunder. 
 3. Stock Available for Awards 
 a. Number of Shares. Subject to
adjustment under Section 3(b), the aggregate number of shares of Common Stock of the Company (the “Common Stock”) that may be issued pursuant to the Plan is seventeen million six hundred twenty two thousand nine hundred eighty five
(17,622,985) shares. If any Award expires, or is terminated, surrendered or forfeited, in whole or in part, the unissued Common Stock covered by such Award shall again be available for the grant of Awards under the Plan. If unvested shares of
Common Stock issued pursuant to the Plan are repurchased by, or are surrendered or forfeited to, the Company at no more than cost, such shares of Common Stock shall again be available for the grant of Awards under the Plan; provided, however, that
the cumulative number of shares that may be issued under the Plan will not exceed seventeen million six hundred twenty two thousand nine hundred eighty five (17,622,985). If any shares of Common Stock subject to an Award are not delivered to a
Participant because such shares are withheld for the payment of taxes, then the number of shares that are not delivered shall revert to and again become available for issuance under the Plan. Shares issued under the Plan may consist in whole or in
part of authorized but unissued shares or treasury shares. 
 b. Adjustment to Common Stock. In the event of any stock
split, stock dividend, extraordinary cash dividend, recapitalization, reorganization, merger, consolidation, combination, exchange of shares, liquidation, spin-off, split-up, or other similar change in capitalization or event, (i) the number
and class of securities available for Awards under the Plan and the per- Participant share limit, (ii) the number and class of securities, vesting schedule and exercise price per share subject to each
outstanding Option, (iii) the repurchase price per security subject to repurchase, and (iv) the terms of each other outstanding stock-based Award shall be adjusted by the Company (or substituted Awards may be made) to the extent the Board
shall determine, in good faith, that such an adjustment (or substitution) is appropriate. If Section 7(e)(i) applies for any event, this Section 3(b) shall not be applicable. 

  
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 4. Stock Options 
 a. General. The Board may grant options to purchase Common Stock (each, an “Option”) and determine the number of shares of Common Stock to be covered by each Option, the exercise
price of each Option, which shall not be less than one hundred percent (100%) of the fair market value of the Common Stock subject to the Option on the date the Option is granted, and the conditions and limitations applicable to the exercise of
each Option and the Common Stock issued upon the exercise of each Option, including vesting provisions, repurchase provisions, right of first refusal provisions and restrictions relating to applicable federal or state securities laws, as it
considers advisable. 
 b. Incentive Stock Options. An Option that the Board intends to be an “incentive stock
option” as defined in Section 422 of the Code (an “Incentive Stock Option”) shall be granted only to employees of the Company and shall be subject to and shall be construed consistently with the requirements of
Section 422 of the Code. The Board and the Company shall have no liability if an Option or any part thereof that is intended to be an Incentive Stock Option does not qualify as such. An Option or any part thereof that does not qualify as an
Incentive Stock Option is referred to herein as a “Nonstatutory Stock Option”. 
 c. Exercise Price. The
Board shall establish the exercise price (or determine the method by which the exercise price shall be determined) at the time each Option is granted and specify it in the applicable option agreement; provided, however, that
(a) subject to clause (b) below, the exercise price of each Option shall be not less than one hundred percent (100%) of the fair market value of the Common Stock subject to the Option on the date the Option is granted (as determined
by the Board in its sole discretion) and (b) the exercise price of each Incentive Stock Option granted to a person who owns (or is deemed to own pursuant to Section 424(d) of the Code) stock possessing more than ten percent (10%) of
the total combined voting power of all classes of stock of the Company shall be not less than one hundred ten percent (110%) of the fair market value of the Common Stock subject to the Option on the date the Option is granted (as determined by
the Board in its sole discretion). Notwithstanding the foregoing, an Incentive Stock Option may be granted with an exercise price lower than as set forth in the preceding sentence if such Option is granted pursuant to an assumption or substitution
for another option in a manner satisfying the provisions of Section 424(a) of the Code. 
 d. Duration of Options.
Each Option shall be exercisable at such times and subject to such terms and conditions as the Board may specify in the applicable option agreement. 
 e. Exercise of Option. Options may be exercised only by delivery to the Company of a written notice of exercise signed by the proper person together with payment in full as specified in
Section 4(±) for the number of shares for which the Option is exercised. 

  
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 f. Payment Upon Exercise. Common Stock purchased upon the exercise of an Option shall
be paid for by one or any combination of the following forms of payment: 
 (i) by check payable to the order of the Company;

 (ii) except as otherwise explicitly provided in the applicable option agreement, and only if the Common Stock is then publicly
traded, delivery of an irrevocable and unconditional undertaking by a creditworthy broker to deliver promptly to the Company sufficient funds to pay the exercise price, or delivery by the Participant to the Company of a copy of irrevocable and
unconditional instructions to a creditworthy broker to deliver promptly to the Company cash or a check sufficient to pay the exercise price; or 
 (iii) to the extent explicitly provided in the applicable option agreement, by (w) delivery of shares of Common Stock owned by the Participant valued at fair market value (as determined by the Board
or as determined pursuant to the applicable option agreement), (x) delivery of a promissory note of the Participant to the Company in a form and subject to such terms and conditions as are satisfactory to the Company (and delivery to the
Company by the Participant of a check or payment of other lawful consideration (as determined by the Board in its sole discretion) in an amount equal to the par value of the shares purchased), (y) by a “net exercise” of the Option (as
further described below) or (z) payment of such other lawful consideration as the Board may determine. In the case of a “net exercise” of an Option, the Company will not require a payment of the exercise price of the Option from the
Participant but will reduce the number of shares of Common Stock issued upon the exercise by the largest number of whole shares that has a fair market value that does not exceed the aggregate exercise price. With respect to any remaining balance of
the aggregate exercise price, the Company shall accept a cash payment from the Participant. The shares of Common Stock so used to pay the exercise price of an Option under a “net exercise” will be considered to have resulted from the
exercise of the Option, and accordingly, the Option will not again be exercisable with respect to such shares, the shares actually delivered to the Participant, and any shares withheld for purposes of tax withholding. 

5. Restricted Stock 
 a.
Grants. The Board may grant Awards entitling recipients to acquire shares of Common Stock, subject to (i) delivery to the Company by the Participant of a check or payment of other lawful consideration (as determined by the Board in its
sole discretion) in an amount at least equal to the par value of the shares purchased, and (ii) the right of the Company to repurchase all or part of such shares at their issue price or other stated or formula price from the Participant in the
event that conditions specified by the Board in the applicable Award are not satisfied prior to the end of the applicable restriction period or periods established by the Board for such Award (each, a “Restricted Stock Award”).

 b. Terms and Conditions. The Board shall determine the terms and conditions of any such Restricted Stock Award
including vesting provisions, repurchase provisions, right of first refusal provisions and restrictions relating to applicable federal or state securities laws, as it 

  
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considers advisable. Any stock certificates issued in respect of a Restricted Stock Award shall be registered in the name of the Participant and, unless otherwise determined by the Board,
deposited by the Participant, together with a stock power endorsed in blank, with the Company (or its designee). After the expiration of the applicable restriction periods, the Company (or such designee) shall deliver the certificates no longer
subject to such restrictions to the Participant or, if the Participant has died, to the beneficiary designated by a Participant, in a manner determined by the Board, to receive amounts due or exercise rights of the Participant in the event of the
Participant’s death (the “Designated Beneficiary”). In the absence of an effective designation by a Participant, Designated Beneficiary shall mean the Participant’s estate. 

6. Other Stock-Based Awards 
 The Board shall have the right to grant other Awards based upon the Common Stock having such terms and conditions as the Board may determine, including, without limitation, the grant of shares based upon
certain conditions, the grant of securities convertible into Common Stock and the grant of stock appreciation rights, phantom stock awards or stock units. 
 7. General Provisions Applicable to Awards 
 a. Transferability of
Awards. Except as the Board may otherwise determine or provide in an Award, Awards shall not be sold, assigned, transferred, pledged or otherwise encumbered by the person to whom they are granted, either voluntarily or by operation of law,
except by will or the laws of descent and distribution, and, during the life of the Participant, shall be exercisable only by the Participant. References to a Participant, to the extent relevant in the context, shall include references to authorized
transferees. 
 b. Documentation. Each Award under the Plan shall be evidenced by a written instrument in such form as the
Board shall determine or as executed by an officer of the Company pursuant to authority delegated by the Board. Each Award may contain terms and conditions in addition to those set forth in the Plan provided that such terms and conditions do
not contravene the provisions of the Plan. 
 c. Board Discretion. The terms of each type of Award need not be identical,
and the Board need not treat Participants uniformly. 
 d. Termination of Status. The Board shall determine the effect on
an Award of the disability, death, retirement, authorized leave of absence or other change in the employment or other status of a Participant and the extent to which, and the period during which, the Participant, or the Participant’s legal
representative, conservator, guardian or Designated Beneficiary, may exercise rights under the Award. 

  
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 e. Acquisition of the Company 

(i) Consequences of an Acquisition. 
 (A) Unless otherwise expressly provided in the applicable Award agreement, upon the occurrence of an Acquisition, the Board or the board of directors of the surviving or acquiring entity (as used in this
Section 7(e)(i)(B), also the “Board”), shall, as to outstanding Awards (on the same basis or on different bases, as the Board shall specify), make appropriate provision for the continuation of such Awards by the Company or the
assumption of such Awards by the surviving or acquiring entity and by substituting on an equitable basis for the shares then subject to such Awards either (a) the consideration payable with respect to the outstanding shares of Common Stock in
connection with the Acquisition, (b) shares of stock of the surviving or acquiring corporation or (c) such other securities as the Board deems appropriate, the fair market value of which (as determined by the Board in its sole discretion)
in each case described in the preceding clauses (a) – (c), shall not materially differ from the fair market value of the shares of Common Stock subject to such Awards immediately preceding the Acquisition. In addition to or in lieu of the
foregoing, with respect to (x) outstanding Options that are then exercisable or will become exercisable as a result of the Acquisition, the Board may, upon written notice to the affected optionees, provide that one or more such Options must be
exercised, to the extent then exercisable or to be exercisable as a result of the Acquisition, within a specified number of days of the date of such notice, at the end of which period such Options shall terminate (including, for the avoidance of
confusion, terminating the portion of any such Option that is not then exercisable and will not become exercisable as a result of the Acquisition); or terminate one or more such Options (including, for the avoidance of confusion, terminating the
portion of any such Option that is not then exercisable and will not become exercisable as a result of the Acquisition) in exchange for a cash payment equal to the excess of the fair market value (as determined by the Board in its sole discretion)
of the shares subject to such Options (to the extent then exercisable or to be exercisable as a result of the Acquisition) over the exercise price thereof and (y) outstanding Options that are not then exercisable and will not become exercisable
as a result of the Acquisition, the Board may, upon written notice to the affected optionees, provide that one or more such Options shall be terminated. In the event that any such Participant who remains an employee of the Company or the acquiring
or surviving entity immediately following the consummation of the Acquisition is terminated without “cause” (as defined in the applicable option agreement) or terminates his or her own employment “for good reason”
(as defined in the applicable option agreement) prior to the first anniversary of the consummation of the Acquisition, then (1) all Options then outstanding shall become immediately exercisable in full and will terminate, to the extent
unexercised, on their scheduled expiration date, and if the shares of Common Stock subject to such Options are subject to repurchase provisions then such repurchase restrictions shall immediately lapse; (2) all Restricted Stock Awards then
outstanding shall become free of all repurchase provisions; and (3) all other stock-based Awards shall become exercisable, realizable or vested in full, or shall be free of all repurchase provisions, as the case may be. 

  
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 (B) Acquisition Defined. An “Acquisition” shall mean: (x) any
merger or consolidation after which the voting securities of the Company outstanding immediately prior thereto represent (either by remaining outstanding or by being converted into voting securities of the surviving or acquiring entity) less than
50% of the combined voting power of the voting securities of the Company or such surviving or acquiring entity outstanding immediately after such event; or (y) any sale of all or substantially all of the assets or capital stock of the Company
(other than in a spin-off or similar transaction) or (z) any other acquisition of the business of the Company, as determined by the Board. 
 (ii) Assumption of Options Upon Certain Events. In connection with a merger or consolidation of an entity with the Company or the acquisition by the Company of property or stock of an entity, the
Board may grant Awards under the Plan in substitution for stock and stock- based awards issued by such entity or an affiliate thereof. The substitute Awards shall be granted on such terms and conditions as the
Board considers appropriate in the circumstances. 
 (iii) Parachute Awards. Notwithstanding the provisions of
Section 7(e)(i)(A), if, in connection with an Acquisition described therein, a tax under Section 4999 of the Code would be imposed on the Participant (after taking into account the exceptions set forth in Sections 280G(b)(4) and 280G(b)(5)
of the Code), then the number of Awards which shall become exercisable, realizable or vested as provided in such section shall be reduced (or delayed), to the minimum extent necessary, so that no such tax would be imposed on the Participant (the
Awards not becoming so accelerated, realizable or vested, the “Parachute Awards”); provided, however, that if the “aggregate present value” of the Parachute Awards would exceed the tax that, but for
this sentence, would be imposed on the Participant under Section 4999 of the Code in connection with the Acquisition, then the Awards shall become immediately exercisable, realizable and vested without regard to the provisions of this sentence.
For purposes of the preceding sentence, the “aggregate present value” of an Award shall be calculated on an after-tax basis (other than taxes imposed by Section 4999 of the Code) and shall be based on economic principles rather
than the principles set forth under Section 280G of the Code and the regulations promulgated thereunder. All determinations required to be made under this Section 7(e)(iii) shall be made by the Company. 

f. Withholding. Each Participant shall pay to the Company, or make provisions satisfactory to the Company for payment of, any taxes
required by law to be withheld in connection with Awards to such Participant no later than the date of the event creating the tax liability. The Board may allow Participants to satisfy such tax obligations in whole or in part by transferring shares
of Common Stock, including shares retained from the Award creating the tax obligation, valued at their fair market value (as determined by the Board or as determined pursuant to the applicable option agreement). The Company may, to the extent
permitted by law, deduct any such tax obligations from any payment of any kind otherwise due to a Participant. 
 g. Amendment
of Awards. The Board may amend, modify or terminate any outstanding Award including, but not limited to, substituting therefor another Award of the same or a different type, changing the date of exercise or realization, arid converting an
Incentive Stock Option to a Nonstatutory Stock Option, provided that the Participant’s consent to such action shall be required unless the Board determines that the action, taking into account any related action, would not materially and
adversely affect the Participant. 

  
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 h. Conditions on Delivery of Stock. The Company will not be obligated to deliver any
shares of Common Stock pursuant to the Plan or to remove restrictions from shares previously delivered under the Plan until (i) all conditions of the Award have been met or removed to the satisfaction of the Company, (ii) in the opinion of
the Company’s counsel, all other legal matters in connection with the issuance and delivery of such shares have been satisfied, including any applicable securities laws and any applicable stock exchange or stock market rules and regulations,
and (iii) the Participant has executed and delivered to the Company such representations or agreements as the Company may consider appropriate to satisfy the requirements of any applicable laws, rules or regulations. 

i. Acceleration. The Board may at any time provide that any Options shall become immediately exercisable in full or in part, that
any Restricted Stock Awards shall be free of some or all restrictions, or that any other stock-based Awards may become exercisable in full or in part or free of some or all restrictions or conditions, or otherwise realizable in full or in part, as
the case may be, despite the fact that the foregoing actions may (i) cause the application of Sections 280G and 4999 of the Code if a change in control of the Company occurs, or (ii) disqualify all or part of the Option as an Incentive
Stock Option. 
 8. Miscellaneous 
 a. Definitions. 
 (i) “Company” for purposes of eligibility
under the Plan, shall include any subsidiary corporations of InfraReDx, Inc., as defined in Section 424(f) of the Code (a “Subsidiary”), and any parent corporation of InfraReDx, Inc., as defined in Section 424(e) of the
Code. For purposes of Awards other than Incentive Stock Options, the term “Company” shall include any other business venture in which the Company has a direct or indirect significant interest, as determined by the Board in its sole
discretion. 
 (ii) “Code” means the Internal Revenue Code of 1986, as amended, and any regulations promulgated
thereunder. 
 b. No Right To Employment or Other Status. No person shall have any claim or right to be granted an Award,
and the grant of an Award shall not be construed as giving a Participant the right to continued employment or any other relationship with the Company. The Company expressly reserves the right at any time to dismiss or otherwise terminate its
relationship with a Participant free from any liability or claim under the Plan. 
 c. No Rights As Stockholder. Subject
to the provisions of the applicable Award, no Participant or Designated Beneficiary shall have any rights as a stockholder with respect to any shares of Common Stock to be distributed with respect to an Award until becoming the record holder
thereof. 

  
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 d. Effective Date and Term of Plan. The Plan shall become effective on the date on
which it is adopted by the Board. No Awards shall be granted under the Plan after the completion of ten years from the date on which the Plan was adopted by the Board, but Awards previously granted may extend beyond that date. 

e. Amendment of Plan. The Board may amend, suspend or terminate the Plan or any portion thereof at any time. 

f. Governing Law. The provisions of the Plan and all Awards made hereunder shall be governed by and interpreted in accordance with
the laws of Massachusetts, without regard to any applicable conflicts of law. 
 [Remainder of Page Intentionally Left Blank.]

  
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 AMENDMENT NO. 1 TO 

INFRAREDX, INC. 
 AMENDED AND RESTATED 1999 STOCK OPTION AND INCENTIVE PLAN 

RECITALS: 
 A. The Board of Directors of InfraReDx, Inc., a Delaware corporation (the “Company”), has previously adopted and approved the Company’s Amended and Restated 1999 Stock
Option and Incentive Plan (the “Plan”). 
 B. By action of the Company’s Board of Directors
on November 14, 2007, and by action of the Company’s stockholders as of November 29, 2007, the share reserve under the Plan has been increased and the adoption of the following amendment to the Plan has been authorized. 

AMENDMENT: 
 1. Section 3(a) of the Plan shall be amended and restated in its entirety as follows: 
 “a. Number of Shares. Subject to adjustment under Section 3(b), the aggregate number of shares of Common Stock of the Company (the “Common Stock”) that may be issued pursuant to
the Plan is 12,922,985 shares. If any Award expires, or is terminated, surrendered or forfeited, in whole or in part, the unissued Common Stock covered by such Award shall again be available for the grant of Awards under the Plan. If unvested shares
of Common Stock issued pursuant to the Plan are repurchased by, or are surrendered or forfeited to, the Company at no more than cost, such shares of Common Stock shall again be available for the grant of Awards under the Plan; provided, however,
that the cumulative number of shares that may be issued under the Plan will not exceed 12,922,985. If any shares of Common Stock subject to an Award are not delivered to a Participant because such shares are withheld for the payment of taxes, then
the number of shares that are not delivered shall revert to and again become available for issuance under the Plan. Shares issued under the Plan may consist in whole or in part of authorized but unissued shares or treasury shares.” 

2. Except as set forth in this amendment, the Plan shall be unaffected hereby and shall remain in full force and effect.

 * * * 

[SIGNATURE PAGE FOLLOWS] 

 The undersigned hereby certifies that the foregoing amendment to the Plan was duly approved
and adopted as provided above and has executed this amendment to the Plan as of November 29, 2007. 
  

			
	INFRAREDX, INC.
		
	By:	 	 /s/ James E. Muller

		 	James E. Muller, M.D.
		 	Chief Executive Officer

 [SIGNATURE PAGE TO AMENDMENT
NO. 1 TO 
 AMENDED AND RESTATED 1999
STOCK OPTION AND INCENTIVE PLAN] 

 AMENDMENT NO. 2 TO 

INFRAREDX, INC. 
 AMENDED AND RESTATED 1999 STOCK OPTION AND INCENTIVE PLAN 

RECITALS: 
 A. The Board of Directors of InfraReDx, Inc., a Delaware corporation (the “Company”), adopted and approved the Company’s Amended and Restated 1999 Stock Option and
Incentive Plan on January 10, 2007 (the “Plan”) and the stockholders of the Company adopted and approved the Plan on November 29, 2007. 
 B. By action of the Company’s Board of Directors on November 14, 2007, and by action of the Company’s stockholders as of November 29, 2007, the aggregate maximum number of
shares that may be granted pursuant to the Plan was increased by 2,000,000 from 10,922,985 to 12,922,985. 
 C. By action
of the Company’s Board of Directors on May 21, 2008, the Plan, as amended, was further amended as provided herein. 

AMENDMENT: 
 1. Section 7(e)(i) of the Plan, as amended, is hereby amended and restated in its entirety as follows: 
 “(i) Consequences of an Acquisition. 
 (A) Continuation or
Assumption of Awards. Unless otherwise expressly provided in the applicable Award agreement, upon the occurrence of an Acquisition, the Board or the board of directors of the surviving or acquiring entity (as used in this Section 7(e)(i),
also the “Board”), shall, as to outstanding Awards (on the same basis or on different bases, as the Board shall specify), make appropriate provision for the continuation of such Awards by the Company or the assumption of such Awards
by the surviving or acquiring entity and by substituting on an equitable basis for the shares then subject to such Awards either (a) the consideration payable with respect to the outstanding shares of Common Stock in connection with the
Acquisition, (b) shares of stock of the surviving or acquiring corporation or (c) such other securities as the Board deems appropriate, the fair market value of which (as determined by the Board in its sole discretion) in each case
described in the preceding clauses (a) – (c), shall not materially differ from the fair market value of the shares of Common Stock subject to such Awards immediately preceding the Acquisition. 

(B) Automatic Acceleration of Vesting of Awards held by Employees. Unless Otherwise expressly provided in the applicable Award
agreement, upon the occurrence of an Acquisition, (a) the vesting of each Award that is continued by the Company or assumed by the surviving or acquiring entity pursuant to Section 7(e)(i)(A) and that is held by a Participant who is an
employee of the Company as of immediately prior to the closing of such Acquisition shall be accelerated on a pro rata basis such that the vesting of 50% of the shares subject to each future vesting installment of such Award will be accelerated and
become immediately exercisable 

 
and/or free from repurchase restrictions, as applicable, and (b) the vesting and exercisability of each Award that is not continued by the Company or assumed by the surviving or
acquiring entity pursuant to Section 7(e)(i)(A) and that is held by a Participant who is an employee of the Company as of immediately prior to the closing of such Acquisition shall be accelerated in full such that the vesting of all of the
shares subject to each future vesting installment of such Award will be accelerated and become immediately exercisable and/or free from repurchase restrictions, as applicable. 
 (C) Election Not to Assume or Continue Outstanding Options. In addition to or in lieu of continuing or assuming outstanding Options pursuant to Section 7(e)(i)(A), with respect to
(x) outstanding Options that are then exercisable or will become exercisable as a result of the Acquisition, the Board may, upon written notice to the affected optionees, provide that one or more such Options must be exercised, to the extent
then exercisable or to be exercisable as a result of the Acquisition, within a specified number of days of the date of such notice, at the end of which period such Options shall terminate (including, for the avoidance of confusion, terminating the
portion of any such Option that is not then exercisable and will not become exercisable as a result of the Acquisition); or terminate one or more such Options (including, for the avoidance of confusion, terminating the portion of any such Option
that is not then exercisable and will not become exercisable as a result of the Acquisition) in exchange for a cash payment equal to the excess of the fair market value (as determined by the Board in its sole discretion) of the shares subject to
such Options (to the extent then exercisable or to be exercisable as a result of the Acquisition) over the exercise price thereof and (y) outstanding Options that are not then exercisable and will not become exercisable as a result of the
Acquisition, the Board may, upon written notice to the affected optionees, provide that one or more such Options shall be terminated. 
 (D) Double Trigger Acceleration of Continued or Assumed Awards Held by Participants Who Remain Employees. In the event that any Participant who remains an employee of the Company or the acquiring
or surviving entity immediately following the consummation of the Acquisition is terminated without “cause” (as defined in the applicable Award agreement) or terminates his or her own employment “for good reason”
(as defined in the applicable Award agreement) prior to the first anniversary of the consummation of the Acquisition, then (1) all continued or assumed Options then outstanding and held by such Participant shall become immediately exercisable
in full and will terminate, to the extent unexercised, on their scheduled expiration date, and if the shares of Common Stock subject to such Options are subject to repurchase provisions then such repurchase restrictions shall immediately lapse;
(2) all Restricted Stock Awards then outstanding and held by such Participant shall become free of all repurchase provisions; and (3) all other continued or assumed stock- based Awards then outstanding and held by such Participant shall
become exercisable, realizable or vested in full, or shall be free of all repurchase provisions, as the case may be. 
 (E)
Acquisition Defined. An “Acquisition” shall mean: (x) any merger or consolidation after which the voting securities of the Company outstanding immediately prior thereto represent (either by remaining outstanding or by being
converted into voting securities of the surviving or acquiring entity) less than 50% of the combined voting power of the voting securities of the Company or such surviving or acquiring entity outstanding immediately after such event; or (y) any
sale of all or substantially all of the assets or capital stock of the Company (other than a spin-off or similar transaction) or (z) any other acquisition of the business of the Company, as determined by the Board. 

 2. The reference to “Section 7(e)(i)(A)” in Section 7(e)(iii) of the
Plan, as amended, is hereby amended and restated as a reference to “Section 7(e)(i).” 
 3. Except as set forth
in this amendment, the Plan shall be unaffected hereby and shall remain in full force and effect. 
 *   *
  *EX-10.6

 Exhibit 10.6 

 
 

 
 34 Third Avenue • Burlington, MA 01803 • Phone: 781.221.0053 • Fax: 781.272.5290 •
www.infraredx.com 
 January 14, 2011 
 Donald Southard 
 Dear Don: 
 It is my pleasure to offer you the position of President and Chief Executive Officer and member of the Board of Directors of InfraReDx, Inc. (the “Company” or
“InfraReDx”) effective February 1, 2011. The InfraReDx team is very impressed with your background and accomplishments and we feel that you will be able to make significant contributions to the Company’s future. It
will be a great personal pleasure for me to work with an executive of your experience and skill in building a successful medical device company. On behalf of InfraReDx, I set forth below the terms of your offer of employment:

 Serving in the capacity of President and Chief Executive Officer, you will perform such duties as are normally associated with this
position and such other duties as may from time to time be assigned to you by the Company. You will report to the Board of Directors of the Company. 
 1. Base Salary. Your bi-weekly salary will be $13,461.54 ($350,000 on an annualized basis)(the “Base Salary”). Your Base Salary may be adjusted from time to time in accordance with
normal business practice and at the sole discretion of the Company. Please note that the annualized amount of your Base Salary as described above is set forth as a matter of convenience, and shall not constitute or be interpreted as an agreement by
the Company to employ you for any specific period of time. 
 2. Relocation. The Company will provide you with reimbursement for
relocation and moving expenses incurred by you in connection with the sale of your home in California and your relocation to the Boston, MA area (the “Relocation Reimbursement”), consisting of reimbursement for (a) reasonable moving
expenses estimated to be approximately $20,000, (these funds include costs to transport your car by driving it from California to Boston), (b) reasonable interim living expenses for up to seven (7) days while traveling on house hunting
trip(s), (c) reasonable travel expenses consisting of economy-class airfare for up to two (2) trips for you and your family from San Jose or San Francisco International Airport to Boston’s Logan Airport, (d) a rental car during
your interim stays in Massachusetts prior to your permanent relocation to Massachusetts, (e) up to $5,000 per month for twelve months to cover housing allowance, including a single gross up for estimated taxes. In the event that you are unable
to sell your home within one year, the Company will consider extending the housing allowance, and (f) the reasonable cost of meals for you and your family while you are searching for your new residence in Massachusetts. To be eligible for the
Relocation Reimbursement, you must present the Company with reasonable documentation evidencing the nature and amount of relocation 

 
expenses incurred. The Company will provide you with the Relocation Reimbursement within thirty (30) days following its receipt of such documentation. If you choose to resign from InfraReDx
or are terminated for “Cause” (as defined below in Section 6D), within twelve (12) months following your first day of employment with the Company, you will be responsible for repayment of the entire amount of the Relocation
Reimbursement that InfraReDx provided you with prior to the termination of your employment. 
 3. Vacation. You will be eligible to
accrue up to a maximum of twenty (20) days of paid vacation time per year, subject to the terms and conditions of the Company’s vacation pay policy. 
 4. Discretionary Bonus. You will be eligible to receive an annual cash incentive bonus of up to fifty percent (50%) of your annual Base Salary (the “Bonus”). The Bonus shall
be based on attainment of certain performance goals and milestones submitted to and approved by the Company’s Board of Directors (the “Board”). The Board shall have sole and absolute discretion to determine whether the performance
criteria have been met for purposes of any such Bonus award. If a Bonus is awarded to you, it shall be paid within first quarter of the calendar year immediately following the year with respect to which the Bonus is earned, in accordance with the
Company’s normal payroll practices and subject to applicable withholdings and deductions as required by law. In addition, you must be satisfactorily employed by the Company on the last day of the applicable calendar year to which such Bonus
relates in order to be eligible for, and to be deemed as having earned, such Bonus. 
 5. Stock Options. Subject to the approval of
the Company’s Board of Directors, you will be granted incentive stock options (to the extent allowable under Section 422 of the Internal Revenue Code of 1986, as amended, and any regulations promulgated thereunder (the “Code”))
under the Company’s Amended and Restated 1999 Stock Option and Incentive Plan (the “Plan”) entitling you to purchase 3.5% of the Company’s fully diluted shares outstanding, post the Company’s closing of its Series E
financing (as adjusted for stock splits, dividends and the like after the date hereof), subject to the terms and conditions of the Company’s standard option agreement (the “Award”). The per share exercise price of the Award will be
the fair market value for Common Stock as of the date that the Board of Directors approves the Award. The options subject to the Award will be unvested on the date of grant and will vest with respect to 25% of the total options subject to the Award
on the one year anniversary of your employment start date, and at a rate of 2.08333% of the total options subject to the Award on the first day of each month thereafter until the Award is fully vested. Such options are intended to be incentive stock
options to the extent allowable under Section 422 of the Code). Moreover, if the Company grants you any additional stock options during the course of your employment with the Company, such stock options shall also be intended to be incentive
stock options to the extent allowable under Section 422 of the Code. 
 In addition, we understand it is your intention to propose a stock
option grant and a cash bonus possibility to the Board of Directors for other employees in the Company. 

  
 

 

 6. Termination Payments. 

A. Separation Pay and Benefits. You will be eligible to receive severance pay and benefits under certain circumstances, as follows:

 (i) In the event that your employment is terminated by the Company without “Cause” (as defined
below) or by you for “Good Reason” (as defined below) then, subject to and expressly conditioned on your execution and non-revocation of a “Separation Agreement” (as described below), you will be eligible to receive
(a) continuation of your then current Base Salary for twelve (12) months from and after the date of termination (the “Separation Date”), beginning on sixtieth (60th) day following your “Separation from Service” (as defined below), payable in accordance with the
Company’s normal payroll practices and subject to all applicable withholdings and deductions, and (b) to the extent you are participating in the Company’s group health and dental insurance plans on your Separation Date, and you comply
with the provisions of the Consolidated Omnibus Budget Reconciliation Act of 1985 (“COBRA”) with respect to benefits continuation including, without limitation, by making a valid COBRA election, the Company will pay your portion of the
COBRA premiums equal to the amount that the Company contributed to such plans on your behalf during your employment with InfraReDx, for a period of twelve (12) months following the Separation Date. 

(ii) In addition to and notwithstanding the foregoing, if your employment is terminated by the Company without “Cause” (as
defined below) or by you for “Good Reason” (as defined below) within twelve (12) months after the consummation of an “Acquisition” of the Company (as that term is defined in the Company’s Certificate of Incorporation,
in effect on the date hereof), then any outstanding but unvested stock options that have previously been granted to you by the Company shall be subject to accelerated vesting pursuant to the terms of the Company’s Stock Option Plan. 

(iii) If you are eligible to receive salary and benefits continuation pursuant to Section 6A(i) above, then, during the twelve
(12) month period following the Separation Date, (a) any unvested stock options that you hold as of the Separation Date shall continue to vest, and all vested options shall remain vested and exercisable by you during such twelve
(12) month period, and (b) you will be eligible for acceleration of unvested stock options pursuant to the terms of Section 6A (ii) above. 
 B. Separation from Service. If any of the benefits and compensation set forth in Section 6A above are non-qualified deferred compensation under Section 409A of the Code, any termination
of employment triggering payment of such benefits must constitute a “separation from service” within the meaning of Treas. Reg. § 1.409A-1(h) (a “Separation from Service”) before distribution of such benefits can commence.
For purposes of clarification, this Section shall not cause any forfeiture of benefits on your part, but shall only act as a delay until such time as a Separation from Service occurs. 

C. Conditions on Receipt of Separation Pay and Benefits. Your eligibility to receive the salary and benefits continuation, and
acceleration of vesting on outstanding stock options, as described in Section 6A above, is expressly conditioned on and subject to the following: (i) you must return all Company property (unless agreed upon as an exception) in your
possession on or prior to the Separation Date; (ii) you must comply with and adhere to the post-termination 

  
 

 

 
obligations described in the Confidentiality, Non-Competition, Non-Solicitation and Assignment of Inventions Agreement (the “Confidentiality Agreement”); and (iii) you must timely
execute, without revocation, a separation agreement in a form that is acceptable to the Company, which will include, at a minimum, (a) a complete release of claims against the Company and its affiliated entities, and its and their officers,
executives, directors, employees, agents, and representatives, and (b) non-disparagement and confidentiality obligations (the “Separation Agreement”). The Separation Agreement must be effective and irrevocable before the sixtieth
(60th) day following the date of your Separation from Service. If the Separation Agreement is not effective and irrevocable in such time period, you shall irrevocably forfeit all compensation and/or benefits described in Section 6A above.

 D. Definition of “Cause”. For purposes of this letter, and more specifically, for purposes of your
eligibility to receive salary and benefits continuation, and acceleration on vesting of stock options (as described in Section 6A above), “Cause” shall be defined as follows: (i) any act of fraud, embezzlement or other material
dishonesty by you with respect to the Company or its parents or subsidiaries; (ii) your willful failure or refusal to perform duties and responsibilities as Chief Executive Officer of the Company; (iii) your commission of, or plea of
nolo contendre to, any act that constitutes a felony under the laws of the Commonwealth of Massachusetts (or, if applicable, the laws of the state in which such act was committed); or (iv) your breach of the Confidentiality Agreement.
Whether Cause exists for purposes of this letter shall be determined by the Board acting in good faith. In addition, if the Company terminates your employment for Cause pursuant to Section 6(D)(ii) above, and the Company concludes that the
events or reasons giving rise to such termination is or are curable, the Company shall provide you with (a) written notice describing the basis for the Cause determination within thirty (30) days of such Cause determination, and
(b) thirty (30) days to remedy the events, reasons, and/or grounds giving rise to the Cause determination (the “Employee Cure Period”) ; provided that, if you fail to cure the events, reasons or grounds giving rise to the
Company’s Cause determination within the Employee Cure Period, then your employment shall immediately be terminated for Cause. 
 E. Definition of “Good Reason”. For purposes of this letter, and more specifically, for purposes of your eligibility to receive salary and benefits continuation, and acceleration on
vesting of stock options (as described in Section 6A above), “Good Reason” shall exist if: (a) the Company (i) materially reduces your then current job duties and responsibilities without your written consent; provided,
however, that a non-material diminution of your title shall not provide the basis for a Good Reason resignation by you, or (ii) materially decreases your then current Base Salary without your written consent, and (b) you provide
written notice to the Company of the circumstances and/or events giving rise to the Good Reason resignation within ninety (90) days of the initial occurrence of the Good Reason event and provide the Company with thirty (30) days to remedy
such circumstances and/or events (the “Company Cure Period”), and the Company fails to remedy such action within the Company Cure Period. If your Separation from Service due to resignation for Good Reason does not occur within 180 days of
the initial occurrence of a Company action described in (a) above, you shall be deemed to consent to such action and shall not be entitled to any Separation Pay and Benefits under Section 6A hereof as a result of thereof. For purposes of
clarification, “Good Reason” shall not include any action taken by the Company, which is subsequently cured by the Company within thirty (30) days of written notice to the Company. 

  
 

 

 7. Certain Payment Delays. Notwithstanding any other provision of this letter to the contrary,
if any amount (including imputed income) to be paid to you pursuant to this letter as a result of your termination of employment is non-qualified “deferred compensation” subject to Section 409A of the Code and any successor statute,
regulation and guidance thereto (“Section 409A of the Code”), and if you are a “Specified Employee” (as defined under Section 409A of the Code) as of the date of your termination of employment hereunder, then, to the extent
necessary to avoid the imposition of excise taxes or other penalties under Section 409A of the Code, the payment of benefits, if any, scheduled to be paid by the Company to you hereunder during the first 6-month period following the date of a
termination of employment hereunder shall not be paid until the date which is the first business day after six (6) months have elapsed since your termination of employment for any reason other than death. Any deferred compensation payments
delayed in accordance with the terms of this Section 7 shall be paid in a lump sum after six (6) months have elapsed since your termination of employment. Any other payments will be made according to the schedule provided for herein.

 8. Adjustment of Excess Payments Payable to an Eligible Employee Subject to Code Section 4999. In the event that it is
determined that any payment(s) or distribution(s) by the Company to you or for your benefit, whether paid or payable or distributed or distributable pursuant to the terms of this letter or otherwise (the “Payments”), would be subject to
the excise tax imposed by Section 4999 of the Code (the “280G Excise Tax”), the Company shall cause to be determined, before any amounts of the Payments are paid to you, which of the following two alternative forms of payment would
maximize your after-tax proceeds: (i) payment in full of the entire amount of the Payments, or (ii) payment of only a part of the Payments so that you receive the largest payment possible without the imposition of the 280G Excise Tax (such
partial payment, the “Reduced Payments”). If it is determined that full payment of the Payments will maximize your after-tax proceeds, then there shall be no adjustment to the Payments pursuant to this Section 8. If it is determined
that payment of the Reduced Payments will maximize your after-tax benefit, then the Company shall determine which Payments to reduce based on what reduction will provide the best economic benefit to you, and shall, in lieu of the full Payments, make
such Reduced Payments to you. Unless you and the Company otherwise agree in writing, any determination required under this Section 8 shall be made in writing by independent public accountants agreed to by you and the Company (the
“Accountants”), whose determination shall be conclusive and binding upon you and the Company for all purposes. For purposes of making the calculations required by this Section 8, the Accountants may rely on reasonable, good faith
interpretations concerning the application of Sections 280G and 4999 of the Code. You and the Company shall furnish to the Accountants such information and documents as the Accountants may reasonably request in order to make the required
determinations. The Company shall bear all fees and expenses the Accountants may reasonably charge in connection with the services contemplated by this Section 8. 
 9. Expenses. For all purposes of this letter, any expense reimbursements made (or any in-kind benefits provided) to you in any one calendar year shall
not affect the amount that may be reimbursed in any other calendar year and a reimbursement or in-kind benefit (or right thereto) may not be exchanged or liquidated for another benefit or payment. Any reimbursement subject to Section 409A of
the Code and the rules and regulations thereunder, shall be made no later than the end of the calendar year following the calendar year in which you incur such expense. 

  
 

 

 10. Tax Consequences. You shall be solely responsible for the payment of all personal tax
liability that is incurred as a result of your receipt of salary and benefits continuation (if any) as described in Section 6A above, and you will not be reimbursed by the Company for any such payment. The Company makes no guarantee of any tax
consequences with respect to the payments and benefits described in this letter, or any other payments from the Company to you including, without limitation, consequences under Section 409A of the Code. 

11. Interpretation and Administration. Notwithstanding any other provision of this letter to the contrary, in the event of an ambiguity in
any of the terms of this letter, the terms shall be interpreted and at all times administered in a manner that avoids the inclusion of compensation in income under Section 409A(a)(1) of the Code. If any of the benefits provided for herein
constitute non-qualified deferred compensation within the meaning of Section 409A of the Code, neither you nor the Company shall have the right to accelerate or defer the delivery of any such payments or benefits except to the extent
specifically permitted or required by Section 409A of the Code. 
 12. Confidentiality Agreement. In consideration for the
Company’s obligations described herein, specifically its promise to provide you with salary and benefits continuation, and acceleration of vesting on stock options (pursuant to Section 6A above), you must execute the enclosed
Confidentiality Agreement and return it to me along with the signed copy of this letter. If you do not execute the Confidentiality Agreement and return it to me as indicated in the immediately preceding sentence, the terms described in
Section 6A of this letter will be null and void, and shall have no force or effect, and the Company shall be under no obligation to provide you with any salary or benefits continuation irrespective of the reasons for the termination of your
employment 
 13. At-Will Employment. Please note that this letter does not consitute an employment contract or a contract for a
specific term of employment, nor will it be deemed or interpreted to constitute an employment contract or a contract for a specific term of employment. Your employment with the Company is and will be on an “at-will” basis, meaning that
either you or the Company may terminate your employment relationship at any time, for any reason, with or without prior notice. 
 14. Your
Certifications to the Company. 
 (a) As a condition of your employment, you certify to the Company that you are free to
enter into and fully perform the duties of your position and that you are not subject to any employment, confidentiality, non-competition or other agreement that would restrict your performance for the Company. You further certify that your signing
this letter of employment does not violate any order, judgment or injunction applicable to you, or conflict with or breach any agreement to which you are a party or by which you are bound. If you are subject to any such agreement or order, please
forward it to Amy Crawford, along with a copy of this letter. 
 (b) Additionally, as a condition of your employment, you also
certify that all facts you have presented to the Company are accurate and true. This includes, but is not limited to, all oral and written statements you have made (including those pertaining to your education, training, qualifications, licensing
and prior work experience) on any job application, resume or c.v., or in any interview or discussion with the Company. 

  
 

 

 15. Miscellaneous. By signing this letter, you acknowledge that the terms described in this
letter, together with the Employee Confidentiality and Developments Agreement, set forth the entire understanding between us and supersedes any prior representations or agreements, whether written or oral; there are no terms, conditions,
representations, warranties or covenants other than those contained herein. No term or provision of this letter may be amended waived, released, discharged or modified except in writing, signed by you and an authorized officer of the Company, except
that the Company may, in its sole discretion, adjust salaries, incentive compensation, stock plans, benefits, job titles, locations, duties, responsibilities, and reporting relationships, subject to other terms and conditions stated herein. By
accepting this offer of employment, you agree that any action, demand, claim or counterclaim in connection with any aspect of your employment with the Company, or any separation of employment (whether voluntary or involuntary) from the Company,
shall be resolved in a court of competent jurisdiction in Massachusetts by a judge alone, and you waive and forever renounce your right to a trial before a civil jury. 
 It will be a great personal pleasure for me to work with you as a partner as we build a large and successful medical imaging company. I am certain that your experience and leadership talents in many areas
will move the Company closer to its goals of improving the safety of stenting, preventing the death and disability caused by coronary artery disease, and generating an excellent financial outcome for employees and investors. 

Sincerely, 
  

	
	/s/ James E. Muller
	James E. Muller, M.D.
	Chief Executive Officer and Chief Medical Officer

  

					
	Acknowledged and Agreed:	 		  	
			
	/s/ Donald Southard	 		  	January 21, 2011
	Donald Southard	 		  	Date

  

	Enclosures:	Employee Confidentiality & Developments Agreement 

  
 

 

  
 

 
 34 Third Avenue • Burlington, MA 01803 • Phone: 781.221.0053 • Fax: 781.272.5290 •
www.infraredx.com 
 January 19, 2011 
 Donald Southard 
  

	 	Re:	Confidentiality, Non-Competition, Non-Solicitation and Assignment of Inventions Agreement 

 Dear Don: 
 As a condition of your employment with InfraReDx, Inc. (the
“Company”), you must sign and return this letter agreement (the “Agreement”). This Agreement confirms your promise to protect and preserve information and property which is confidential and proprietary to the Company, its
subsidiaries and affiliates, as well as other terms and conditions of your employment, including your agreement to reasonable limitations on the scope of your employment once your affiliation with the Company ends. 

As consideration for your agreements and obligations contained herein, you will be eligible to receive severance pay and benefits
following the termination of your employment, in accordance with the terms described in the letter to you dated January 14, 2011, which you have received in conjunction with this Agreement. You acknowledge and agree that only certain, key
Company employees are offered severance benefits, and that as one of these employees, the Company places a high value on your services. Similarly, given your important position with the Company, you are in a unique position to harm the
Company’s legitimate business interests, if you were to accept employment with a Company competitor. Accordingly, in consideration of the severance pay and benefits offered to you, your continued employment by the Company, and other good and
valuable consideration, the sufficiency of which you hereby acknowledge, you agree as follows: 
  

	 	1.	Prohibited Competition. 

 (a) Certain Acknowledgements and Agreements. 
 (i) We have
discussed, and you recognize and acknowledge the competitive and proprietary aspects of the business of the Company. 

 (ii) You acknowledge that a business will be deemed “Competitive”
with the Company if it performs any of the services or manufactures or sells any of the products provided or offered by the Company or if it performs any other services and/or engages in the marketing, production, manufacture, distribution or sale
of any product or service similar to the services or products which were performed, produced, marketed, manufactured, distributed, sold, under development or planned by the Company during your affiliation with the Company, or which could substitute
for such products or services. More specifically, and without limiting the general restriction above, “Competitive” shall mean engaging in a business activity that directly or indirectly relates to the research, development, manufacture,
marketing, selling or servicing of products related to the characterization of tissue by any combination of near-IR spectroscopy, intravascular ultrasound, or optical coherence tomography. 

(iii) You further acknowledge that, during the course of your affiliation with the Company, the Company will furnish,
disclose or make available to you Confidential Information (as defined below) related to the Company’s business and that the Company will provide you with unique and specialized training, experiences and opportunities. You also acknowledge that
such Confidential Information and such training, experiences and opportunities have been developed and will be developed by the Company through the expenditure by the Company of substantial time, effort and money and that all such Confidential
Information and training, experiences and opportunities could be used by you to compete with the Company. You also acknowledge that if you become employed by or affiliated with any competitor of the Company in violation of your obligations to the
Company, it is inevitable that you would disclose the Confidential Information to such competitor and would use such Confidential Information, knowingly or unknowingly, on behalf of such competitor. Further, in the course of your employment with the
Company, you will be introduced to and collaborate with customers and other scientific and business partners of the Company. You acknowledge that any and all “goodwill” created through such relationships belongs exclusively to the Company,
including, without limitation, any goodwill created as a result of direct or indirect contacts or relationships between you and any customers or other contacts of the Company. 

(iv) For purposes of this Agreement, “Confidential Information,” means confidential and proprietary information
of the Company, whether in written, oral, electronic or other form, including but not limited to, information and facts concerning business plans, marketing plans, strategies, forecasts, customers, future customers, suppliers, licensors, licensees,
partners, investors, affiliates or others, training methods and materials, financial information, pricing models and methods, sales prospects, client and partner lists, inventions, tests, test results, product assessments, improvements, inventions,
products, designs, methods, show-how and know-how, techniques, systems, processes, engineering data, software programs, algorithms, formulae, works of authorship, technical data and specifications, or any other scientific, technical or trade secrets
of the Company or of any third party provided to you or the Company; provided that, Confidential 

  
 

 
 2 

 
Information will not include information that is in the public domain other than through any fault or act by you. The phrase, “trade secrets,” as used in this Agreement, will be given
its broadest possible interpretation under the law of the Commonwealth of Massachusetts and will include, without limitation, anything tangible or intangible or electronically kept or stored, which constitutes, represents, evidences or records any
secret scientific, technical, merchandising, production or management information, or any design, process, procedure, formula, invention, improvement or other confidential or proprietary information or documents. 

(b) Non-Competition; Non-Solicitation; Non-Disparagement. During the period in which you are employed by or
otherwise affiliated with the Company and for a period of one (1) year following the last day of your affiliation with the Company for any reason or for no reason, you will not, without the prior written consent of the Company: 

(i) For yourself or on behalf of any other person or entity, directly or indirectly, either as principal, partner,
stockholder, officer, director, member, employee, consultant, agent, representative or in any other capacity, own, manage, operate or control, or be concerned with, connected with or employed by, or otherwise associate in any manner with, engage in,
or have a financial interest in, any business which is directly or indirectly Competitive (as defined in Section 1(a)(ii) above) with the business of the Company (each, a “Restricted Activity”) in any regional area or territory in
which you performed services on behalf of the Company or in which the Company conducted or conducts business (the “Restricted Territory”), except that nothing contained herein will preclude you from purchasing or owning securities of any
such business if such securities are publicly traded, and provided that your holdings do not exceed one percent (1%) of the issued and outstanding securities of any class of securities of such business; or 

(ii) Either individually or on behalf of or through any third party, directly or indirectly, solicit, divert or
appropriate or attempt to solicit, divert or appropriate any customer, client, or other business partner of the Company (or any person or entity which was a customer, client, or business partner of the Company at any time during the six
(6) month period preceding such actual or attempted solicitation, diversion or appropriation), or any prospective customer, client, or business partner with respect to which the Company has developed or made a sales presentation (or similar
offering of services) during the six (6) month period preceding such actual or attempted solicitation, for the purpose of competing with the Company or reducing the Company’s relationship with any customers, clients, or other business
partners of the Company; or 
 (iii) Either individually or on behalf of or through any third party, directly or
indirectly, (A) solicit, entice or persuade or attempt to solicit, entice or persuade any employee of or consultant to the Company to end or reduce such person’s relationship with the Company, or (B) employ, hire, cause to be employed
or engaged, or solicit the employment or the engagement as a consultant of any employee of or consultant to the Company while any such person is affiliated with the Company or within six (6) months after any such person ceases to be affiliated
with the Company; or 

  
 

 
 3 

 (iv) Either individually or on behalf of or through any third party,
directly or indirectly, interfere, with or attempt to interfere with, the relations between the Company and any vendor or supplier to the Company; and/or 
 (v) During your affiliation with the Company and at all times thereafter, you will not make any statement that is professionally or personally disparaging about, or adverse to, the interests of the
Company, any of its officers, directors, shareholders or employees including, but not limited to, any statement that disparages any person, product, service, financing, financial condition, capability or other aspect of the Company’s business
or any of its officers, directors, shareholders or employees. You further agree that during your affiliation with the Company and at all times thereafter, you will not engage in any conduct that is intended to or has the result of inflicting harm
upon the professional or personal reputation of the Company or any of its officers, directors, shareholders or employees. 
 (c) Reasonableness of Restrictions. You further recognize and acknowledge that (i) the types of employment which are prohibited by this Section 1 are narrow and reasonable in relation to
the skills which represent your principal salable assets both to the Company and to other prospective employers, and (ii) the specific but broad geographical scope of the provisions of this Section 1 is reasonable, legitimate and fair to
you in light of the nature of the Company’s technology and services, the Company’s need to market and sell its services and products in an appropriate manner and in light of the limited restrictions on the type of activity prohibited
compared to the activities for which you are qualified to earn a livelihood. 
 (d) Survival of
Acknowledgements and Agreements. Your acknowledgements and agreements set forth in this Section 1 will survive the termination of your affiliation with the Company. 
 2. Protected Information. You will at all times, both during the period while you are affiliated with the Company and after your affiliation with the Company ends, maintain in confidence and will
not, without the prior written consent of the Company, use, except in the course of performance of your duties for the Company or by court order, disclose or give to others any Confidential Information. In the event you are questioned by anyone not
employed by or otherwise affiliated with the Company or by an employee of or a consultant to the Company not authorized to receive Confidential Information, in regard to any Confidential Information, or concerning any fact or circumstance relating
thereto, you will promptly notify the Company. Upon the termination of your affiliation with the Company for any reason or for no reason, or if the Company otherwise requests, (a) you will return to the Company all tangible Confidential
Information and copies thereof (regardless how such Confidential Information or copies are maintained), and (b) you will deliver to the Company any property of the Company 

  
 

 
 4 

 
which may be in your possession, including, but not limited to, notes, notebooks, memoranda, reports, lists, records, drawings, sketches, specifications, software programs, software code, data,
graphics, computers, test equipment, models, tools, cellular telephones, pagers, credit and/or calling cards, keys, access cards, documentation or other materials of any nature and in any form, whether written, printed, electronic or in digital
format or otherwise, relating to any matter within the scope of the business of the Company or concerning any of its dealings or affairs and any other Company property in your possession, custody or control (whether prepared by you or others). The
terms of this Section 2 are in addition to, and not in lieu of, any other contractual, statutory, common law, or legal obligation that you may have relating to the protection of the Company’s Confidential Information. The terms of this
Section 2 will survive indefinitely any termination of your affiliation with the Company for any reason or for no reason. 

3. Ownership of Ideas, Copyrights and Patents. 

(a) Property of the Company. All inventions, ideas, discoveries, creations, manuscripts and properties, work
modifications, processes, software programs, works of authorship, documentation, innovations, improvements, know-how, show-how inventions, designs, developments, apparatus, trade secrets, techniques, methods, technical specifications, technical
data, concepts, expressions, and formulae (collectively the “Inventions”), which may be used in the business of the Company, whether or not such Inventions are patentable, copyrightable, or registrable under copyright, trademark or similar
statutes (including but not limited to The Semiconductor Chip Act), which you may conceive, make, author, devise, discover, reduce to practice, or develop (whether alone or in conjunction with another or others) during the period while you are
affiliated with the Company and which in any way relate to the Company’s business, will be the sole and exclusive property of the Company, and you agree to promptly disclose to the Company all such matters, as well as any such matters which you
conceive, make, author, devise, discover, reduce to practice or develop during the six (6) month period following the end of your affiliation with the Company. You agree that you will not publish any of the Inventions without the prior written
consent of the Company or its designee. Without limiting the foregoing, you also acknowledge that all original works of authorship which are made by you (solely or jointly with others) within the scope of your employment or which relate to the
business of the Company or a Company affiliate and which are protectable by copyright are “works made for hire” pursuant to the United States Copyright Act (17 U.S.C. Section 101). You hereby assign to the Company or its designee all
of your right, title and interest in and to all of the foregoing. You further represent that, to the best of your knowledge and belief, none of the Inventions will violate or infringe upon any right, patent, copyright, trademark or right of privacy,
or constitute libel or slander against or violate any other rights of any person, firm or corporation, and that you will use your best efforts to prevent any such violation. 

(b) Cooperation. At any time during or after the period during which you are affiliated with the Company, you will
fully cooperate with the Company and its attorneys and agents in the preparation and filing of all papers and other documents as may be required to perfect the Company’s rights in and to any of such Inventions, including, but not limited to,
joining in any proceeding to obtain letters patent, copyrights, trademarks 

  
 

 
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or other legal rights with respect to any such Inventions in the United States and in any and all other countries, provided that the Company will bear the expense of such proceedings, and that
any patent or other legal right so issued to you personally will be assigned by you to the Company or its designee without charge by you. 
 (c) Licensing and Use of Innovations. With respect to any Inventions, and work of any similar nature (from any source), whenever created, which you have not prepared or originated in the
performance of your employment, but which you provide to the Company or incorporate in any Company product or system, you hereby grant to the Company a royalty-free, fully paid-up, non-exclusive, perpetual and irrevocable license throughout the
world to use, modify, create derivative works from, disclose, publish, translate, reproduce, deliver, perform, dispose of, and to authorize others so to do, all such Inventions. You will not include in any Inventions you deliver to the Company or
use on its behalf, without the prior written approval of the Company, any material which is or will be patented, copyrighted or trademarked by you or others unless you provide the Company with the written permission of the holder of any patent,
copyright or trademark owner for the Company to use such material in a manner consistent with then-current Company policy. 
 (d) Inventions Assigned to the United States. In addition, you agree to assign to the United States government any and all right, title, and interest that you may have in and/or to any and all
Inventions whenever such full title is required to be assigned to the United States by a contract between the Company and the United States or any of its agencies. 

(e) Maintenance of Records. You agree to keep and maintain adequate and current written records of all Inventions
made by you (solely or jointly with others) during the term of your employment with the Company. The records will be in the form of notes, sketches, drawings, laboratory notebooks, and/or any other format that may be required by the Company. The
records will be available to and remain the sole property of the Company at all times. 
 (f) Prior
Inventions. Listed on Exhibit A to this Agreement are any and all Inventions in which you claim or intend to claim any right, title and interest (collectively, “Prior Inventions”), including, without limitation, patent, copyright and
trademark interests, which to the best of your knowledge will be or may be delivered to the Company in the course of your employment, or incorporated into any Company product or system. You acknowledge that your obligation to promptly disclose such
information is ongoing during the period that you are affiliated with the Company. 
 4. Disclosure to Future Employers.
You will provide, and the Company, in its discretion, may provide, a copy of this Agreement to any business or enterprise which you may directly or indirectly own, manage, operate, finance, join, control or in which you may participate in the
ownership, management, operation, financing, or control, or with which you may be connected as an officer, director, employee, partner, principal, agent, representative, consultant or otherwise. 

  
 

 
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 5. No Conflicting Agreements. You hereby represent and warrant that you have no
commitments or obligations inconsistent with this Agreement and you will indemnify and hold the Company harmless against loss, damage, liability or expense arising from any claim based upon circumstances alleged to be inconsistent with such
representation and warranty. In addition: 
 (a) You represent that you have no agreement or other legal
obligation with any prior employer or any other person or entity that restricts your ability to perform any function for the Company. 
 (b) You have been advised by the Company that at no time should you divulge to or use for the benefit of the Company any trade secret or confidential or proprietary information of any previous employer.
You have not divulged or used any such information for the benefit of the Company. 
 (c) You have not and will
not misappropriate any Invention that you played any part in creating while working for any former employer. 

(d) You recognize that the Company has received, and in the future will receive, confidential or proprietary information
from third parties subject to a duty on the Company to maintain the confidentiality of such information and to use it only for certain limited purposes. You agree to hold all such confidential and proprietary information in the strictest confidence
and not to disclose it to any person or entity or to use it except as necessary to carry out your work for the Company consistent with the Company’s agreement with such third parties. 

(e) You acknowledge that the Company has based important business decisions on these representations, and affirm that all
of the statements included herein are true. 
 6. Use of Likeness. You hereby give the Company permission to use your
picture, voice, image, or likeness, during your affiliation with the Company and after your affiliation with the Company ends, with or without using your name, for whatever business purposes the Comapny deems necessary. 

7. General. 
 (a) Agreement Enforceable Upon Material Job Change. You acknowledge and agree that if you should transfer between or among any affiliates of the Company, wherever situated, or be promoted, demoted,
reassigned to functions other than your present functions, or have your job duties changed, altered or modified in any way, all terms of this Agreement shall continue to apply with full force. 

(b) Notices. All notices, requests, consents and other communications hereunder will be in writing, will be
addressed to the receiving party’s address set forth above or to such other address as a party may designate by notice hereunder, and will be either delivered by hand, sent by overnight courier, or sent by registered mail, return

  
 

 
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receipt requested, postage prepaid. All notices, requests, consents and other communications hereunder will be deemed to have been given either (i) if by hand, at the time of the delivery
thereof to the receiving party at the address of such party set forth above, (ii) if sent by overnight courier, on the next business day following the day such notice is delivered to the courier service, or (iii) if sent by registered
mail, on the fifth business day following the day such mailing is made. 
 (c) Entire Agreement. This
Agreement embodies the entire agreement and understanding between the parties hereto with respect to the subject matter hereof and supersedes all prior oral or written agreements and understandings relating to the subject matter hereof. No
statement, representation, warranty, covenant or agreement of any kind not expressly set forth in this Agreement will affect, or be used to interpret, change or restrict, the express terms and provisions of this Agreement. 

(d) Modifications and Amendments. The terms and provisions of this Agreement may be modified or amended only by
written agreement executed by the parties hereto. 
 (e) Waivers and Consents. The terms and provisions of
this Agreement may be waived, or consent for the departure therefrom granted, only by written document executed by the party waiving or consenting to such terms or provisions. No such waiver or consent will be deemed to be or will constitute a
waiver or consent with respect to any other terms or provisions of this Agreement, whether or not similar. Each such waiver or consent will be effective only in the specific instance and for the purpose for which it was given, and will not
constitute a continuing waiver or consent. 
 (f) Assignment. The Company, in its sole and absolute
discretion, may assign its rights and obligations hereunder to any person or entity. You may not assign your rights and obligations under this Agreement without the prior written consent of the Company and any such attempted assignment by you
without the prior written consent of the Company will be void. 
 (g) Benefit. All statements,
representations, warranties, covenants and agreements in this Agreement will be binding on the parties hereto and will inure to the benefit of the respective successors and permitted assigns of each party hereto. Nothing in this Agreement will be
construed to create any rights or obligations except between the Company and you, and no person or entity other than the Company will be regarded as a third-party beneficiary of this Agreement. 

(h) Governing Law. This Agreement shall be deemed to have been made in the Commonwealth of Massachusetts, shall
take effect as an instrument under seal within Massachusetts, and the validity, interpretation and performance of this Agreement shall be governed by, and construed in accordance with, the internal law of Massachusetts, without giving effect to
conflict of law principles, and specifically excluding any conflict or choice of law rule or principle that might otherwise refer construction or interpretation of this Agreement to the substantive law of another jurisdiction. The parties
acknowledge that the last act necessary to render this Agreement enforceable is its execution by the Company in Massachusetts, and that the Agreement shall be maintained in Massachusetts. 

  
 

 
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 (i) Jurisdiction, Venue and Service of Process. Any legal action or
proceeding with respect to this Agreement must be brought in the courts of the Commonwealth of Massachusetts or in the United States District Court for the District of Massachusetts and shall be subject to the jurisdiction of such courts only. By
execution and delivery of this Agreement, each of the parties hereto accepts for itself and in respect of its property, generally and unconditionally, the exclusive jurisdiction of the aforesaid courts. 

(j) Waiver of Jury Trial. Any action, demand, claim or counterclaim arising under or relating to this Agreement
will be resolved by a judge alone and each of the Company and you waive any right to a jury trial thereof. 
 (k)
Severability. The parties intend this Agreement to be enforced as written. However, (i) if any portion or provision of this Agreement is to any extent declared illegal or unenforceable by a duly-authorized court having jurisdiction, then
the remainder of this Agreement, or the application of such portion or provision in circumstances other than those as to which it is so declared illegal or unenforceable, will not be affected thereby, and each portion and provision of this Agreement
will be valid and enforceable to the fullest extent permitted by law, and (ii) if any provision, or part thereof, is held to be unenforceable because of the duration of such provision or the geographic area covered thereby, the court making
such determination will have the power to reduce the duration and/or geographic area of such provision, and/or to delete specific words and phrases (“blue-pencilling”), and in its reduced or blue-pencilled form such provision will then be
enforceable and will be enforced. 
 (1) Headings and Captions. The headings and captions of the various
subdivisions of this Agreement are for convenience of reference only and will in no way modify or affect the meaning or construction of any of the terms or provisions hereof. 

(m) Injunctive Relief. You hereby expressly acknowledge that any breach or threatened breach of any of the terms
and/or conditions set forth in Section 1, 2 or 3 of this Agreement will result in substantial, continuing and irreparable injury to the Company. Therefore, you acknowledge and agree that in addition to any other remedy that may be available to
the Company, the Company will be entitled to injunctive or other equitable relief by a court of appropriate jurisdiction in the event of any breach or threatened breach of the terms of Section 1, 2 or 3 of this Agreement. 

(n) No Waiver of Rights, Powers and Remedies. No failure or delay by a party hereto in exercising any right, power
or remedy under this Agreement, and no course of dealing between the parties hereto or in any trade or industry, will operate as a waiver of any such right, power or remedy of the party. No single or partial exercise of any right, power or remedy
under this Agreement by a party hereto, nor any abandonment or discontinuance of steps to enforce any such right, power or remedy, will preclude such 

  
 

 
 9 

 
party from any other or further exercise thereof or the exercise of any other right, power or remedy hereunder. The election of any remedy by a party hereto will not constitute a waiver of the
right of such party to pursue other available remedies. No notice to or demand on a party not expressly required under this Agreement will entitle the party receiving such notice or demand to any other or further notice or demand in similar or other
circumstances or constitute a waiver of the rights of the party giving such notice or demand to any other or further action in any circumstances without such notice or demand. 

(o) Employment at Will. You understand that neither this Agreement nor any other document that you have signed with
the Company constitutes an implied or written employment contract or guarantee of continued employment and that your employment with the Company is on an “at-will” basis. Accordingly, you understand and agree that your employment with the
Company may be terminated by either you or the Company, at any time, and for any or no reason. 
 (p)
Survival. This entire Agreement, and your obligations hereunder, shall survive any termination or cessation of your affiliation with the Company (for any or no reason). 

(q) Counterparts. This Agreement may be executed in two or more counterparts, and by different parties hereto on
separate counterparts, each of which will be deemed an original, but all of which together will constitute one and the same instrument. 
 (r) Opportunity to Review. You hereby acknowledge that you have had adequate opportunity to review these terms and conditions and to reflect upon and consider the terms and conditions of this
Agreement, and that you have had the opportunity to consult with counsel of your own choosing regarding such terms. You further acknowledge that you fully understand the terms of this Agreement and have voluntarily executed this Agreement.

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 If the foregoing accurately sets forth our agreement, please so indicate by signing and
returning to us the enclosed copy of this letter. 
  

			
	Very truly yours,
	
	InfraReDx, Inc.
		
	By:	 	/s/ Amy K. Crawford
		 	Amy K. Crawford
		 	Director of Human Resources

  

	
	 Accepted and Agreed:

	
	 /s/ Donald Southard

	 Donald Southard

	
	 Dated:  January 21,
2011                    

  
 

 
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 EXHIBIT A 

PRIOR INVENTIONS 

If none, please sign here:
                                         
                                         
                                       

  
 

 
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