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                                                                  EXHIBIT 10.1.F

                        AMENDMENT TO EMPLOYMENT AGREEMENT

         This AMENDMENT TO EMPLOYMENT AGREEMENT (the "Amendment") amends that
certain EMPLOYMENT AGREEMENT by and between CLINTRIALS RESEARCH INC., a Delaware
corporation ("Employer"), and PAUL J. OTTAVIANO ("Employee") dated as of January
1, 1998 (the "Employment Agreement") and is entered into between Employer and
Employee this ____ day of _____________, 2000.

         WHEREAS, the parties wish to amend the Employment Agreement as set
forth below;

         IT IS, ACCORDINGLY, AGREED AS FOLLOWS:

         1. Section 2 of the Employment Agreement is amended to read in its
entirety as follows:

                           2. Term. The term of this Agreement shall be for a
                  period commencing on January 1, 1998 and ending December 31,
                  1998, except that the provisions of Section 8 and 9 will
                  survive the expiration or earlier termination of this
                  Agreement. This Agreement shall be automatically renewed for
                  additional and successive one (1) year periods unless either
                  party provides ninety (90) days notice prior to any
                  anniversary date of its intent not to renew this Agreement
                  (the initial term and any and all renewal terms each being a
                  "Period of Employment"). Employee will continue to be paid
                  full pay and benefits during this ninety (90) day period. In
                  the event Employer elects not to renew this Agreement upon any
                  such anniversary date, Employee will be entitled to receive a
                  severance payment in an amount equal to Employee's base
                  monthly compensation (not including incentive compensation) at
                  the time of non-renewal multiplied by eighteen (18), payable
                  in a lump sum, and all unvested stock options shall become
                  fully vested and shall remain exercisable for the remainder of
                  the stated term of such stock options, regardless of whether
                  the Employee continues to be employed by the Employer.

         2. Section 7c. of the Employment Agreement is amended to read in its
entirety as follows:

                           c. Termination by Employer for Other Than Cause.
                  Employer may terminate the employment of Employee at any time
                  upon written notice to the Employee. In such event, Employee
                  shall be paid the amount of any unpaid salary earned by the
                  Employee up to and including the date of such Termination by
                  Employer, an amount equal to Employee's then current monthly
                  base salary multiplied by eighteen (18), payable in a lump sum
                  and any unpaid vacation pay earned by him up to and including
                  the date of such

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                  Termination by Employer. Also for an eighteen (18) month
                  period from effective date of Termination by Employer,
                  Employer shall continue to make the employer contributions
                  necessary to maintain the Employee's coverage pursuant to all
                  benefit plans provided to the Employee by the Employer
                  immediately prior to such Termination by Employer; and
                  Employer shall deduct from payments payable to the Employee
                  pursuant to this Section the amount of any employee
                  contributions necessary to maintain such coverage, and
                  Employee shall continue to be bound by the provisions of
                  Sections 8 and 9 hereof and all unvested stock options shall
                  become fully vested and shall remain exercisable for the
                  remainder of the stated term of such stock options, regardless
                  of whether the Employee continues to be employed by the
                  Employer.

         3. Section 7f. of the Employment Agreement is amended to read in its
entirety as follows:

                           f. Failure to Renew. If Employer gives Employee
                  notice as provided in Section 2 of its election not to renew
                  this Agreement, Employee's employment shall terminate upon the
                  anniversary date. In such event, Employee shall be paid the
                  amount of any unpaid salary earned by the Employee up to and
                  including the date of such Failure to Renew by Employer, an
                  amount equal to Employee's then current monthly base salary
                  multiplied by eighteen (18) in a lump sum and any unpaid
                  vacation pay earned by him up to and including the date of
                  such Termination by Employer. Also for an eighteen (18) month
                  period from the effective date of termination by Employer,
                  Employer shall continue to make the employer contributions
                  necessary to maintain the Employee's coverage pursuant to all
                  benefit plans provided to the Employee by the Employer
                  immediately prior to such Failure to Renew by Employer, and
                  Employer shall deduct from any payments payable to the
                  Employee pursuant to this Section the amount of any employee
                  contributions necessary to maintain such coverage, and
                  Employee shall continue to be bound by the provisions of
                  Sections 8 and 9 hereof, and all unvested stock options shall
                  become fully vested and shall remain exercisable for the
                  remainder of the stated term of such stock options, regardless
                  of whether the Employee continues to be employed by the
                  Employer.

         4. The first paragraph of Section 7g. of the Employment Agreement is
amended to read in its entirety as follows:

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                           g. Change in Control. In the event there is a "Change
                  in Control" of the ownership of the Employer, and the
                  Employee's employment with the Employer is terminated as a
                  result of such Change in Control, or if the Employee resigns
                  within ninety (90) days following a Change in Control, in
                  either case the Employee shall be entitled to receive as a
                  severance payment following such termination or resignation an
                  amount equal to Employee's base monthly compensation (not
                  including incentive compensation) at the time of termination
                  or resignation multiplied by eighteen (18), payable in a lump
                  sum. In addition, any earned but unpaid base salary, incentive
                  compensation and any unpaid vacation pay earned by him up to
                  and including the date of such termination as a result of
                  Change in Control or resignation will be paid. Also, for the
                  eighteen (18) month period following the termination or
                  resignation date, the Employee will continue to receive the
                  Employer contributions necessary to maintain the Employee's
                  coverage pursuant to all benefit plans provided to the
                  Employee by the Employer immediately prior to such termination
                  as a result of Change in Control or resignation. Employer
                  shall deduct from any payments payable to the Employee
                  pursuant to this Section the amount of any employee
                  contributions necessary to maintain such coverage. Further,
                  any stock options granted to the Employee will be fully vested
                  upon a Change in Control, whether or not the Employee is
                  terminated or resigns, notwithstanding any previously stated
                  vesting restrictions, and shall remain exercisable for the
                  remainder of the stated term of such stock options, regardless
                  of whether the Employee continues to be employed by the
                  Employer. In the event of the termination of employment of the
                  Employee by the Employer without "cause" or resignation as a
                  result of or within ninety (90) days following a Change in
                  Control, if the Employee is required, pursuant to Section 4999
                  of the Internal Revenue Code of 1986, as amended (the "Code"),
                  to pay (through withholding or otherwise) an excise tax on
                  "excess parachute payments" (as defined in Section 280G of the
                  Code), the Employer shall pay the Employee the amount
                  necessary to place the Employee in the same after-tax
                  financial position that he would have been in if he had not
                  incurred any excise tax liability under Section 4999 of the
                  Code.

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         5. In all other respects the Employment Agreement is hereby ratified
and affirmed.

                                       EMPLOYER:

                                       CLINTRIALS RESEARCH INC.

                                       By:
                                           -------------------------------------
                                       Title:
                                             -----------------------------------

                                       EMPLOYEE:

                                       -----------------------------------------
                                       PAUL J. OTTAVIANO

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                                                                  EXHIBIT 10.1.G

                        AMENDMENT TO EMPLOYMENT AGREEMENT

         This AMENDMENT TO EMPLOYMENT AGREEMENT (the "Amendment") amends that
certain EMPLOYMENT AGREEMENT by and between CLINTRIALS RESEARCH INC., a Delaware
corporation ("Company"), and S. COLIN NEILL ("Executive") dated as of October
22, 1998 (the "Employment Agreement") and is entered into between Company and
Executive this ____ day of _____________, 2000.

         WHEREAS, the parties wish to amend the Employment Agreement as set
forth below;

         IT IS, ACCORDINGLY, AGREED AS FOLLOWS:

         1. The last sentence of Section 2(c) of the Employment Agreement is
amended to read as follows:

                  Further, any stock options granted to the Executive will be
                  fully vested upon a Change of Control, whether or not the
                  Executive is terminated, notwithstanding any previously stated
                  vesting restrictions, and will remain exercisable for the
                  remainder of the stated term of such stock option(s),
                  regardless of whether the Executive continues to be employed
                  by the Company.

         2. The following is added after the last sentence of Section 2(c) of
the Employment Agreement:

                  For purposes of this Agreement, "Change of Control" shall mean
                  (i) the acquisition of beneficial ownership (within the
                  meaning of Rule 13d-3 promulgated under the Securities and
                  Exchange Act of 1934, as amended (the "Exchange Act")) of
                  greater than 50% of the then outstanding voting securities of
                  the Company entitled to vote generally in the election of
                  directors (the "Voting Securities") by any individual, entity
                  or group (within the meaning of Section 13(d)(3) of the
                  Exchange Act and the rules and regulations thereunder), other
                  than by the Company, an employee benefit plan (or related
                  trust) sponsored or maintained by the Company; (ii) a sale of
                  all or substantially all of the assets of the Company; (iii) a
                  sale or other transfer of assets of the Company, in one or a
                  series of transactions, representing more than 50% of the
                  total fair market value of the Company's assets immediately
                  prior to the transaction (or the first transaction, if there
                  are a series of transactions); (iv) any merger,

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                  consolidation, reorganization, recapitalization or other
                  corporate transaction with respect to the Company, unless the
                  holders of the Voting Securities immediately prior to such
                  transaction own more than 50% of the voting securities of the
                  entity resulting from such transaction or the entity which
                  controls such resulting entity (in substantially the same
                  percentages as they held prior to such transaction); or (v)
                  the date, following the expiration of any period of twelve
                  consecutive months that individuals, who at the beginning of
                  such period constituted the Board (together with any new
                  directors whose election by such Board or whose nomination for
                  election by the shareholders of the Company was approved by a
                  vote of a majority of the directors of the Company then still
                  in office who were either directors at the beginning of such
                  period or whose election or nomination for election was
                  previously so approved) cease for any reason to constitute a
                  majority of the Board then in office.

         3. The first paragraph of Section 5(c) of the Employment Agreement is
amended to read as follows:

                           (c) Termination Without "Cause" or for "Good Reason"
                  (as such term is defined below). If the Company should
                  terminate the Executive's employment for any reason (including
                  a termination as a result of a Change of Control) other than
                  for Cause, or in the event the Executive terminates employment
                  for Good Reason or Company gives notice of its intent not to
                  renew this Agreement under Section 1(b), the Company shall pay
                  the Executive, in a lump sum within ten (10) days following
                  his termination of employment, an amount equal to the
                  Executive's then current monthly Base Salary times eighteen
                  (18). The Executive shall also be entitled to:

         4. The portion of Section 5(c)(ii) of the Employment Agreement labeled
"(1)" is amended to read as follows:

                  (1) the end of the 18-month period following his termination
                  of employment; and

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         5. The second Section 5(c) of the Employment Agreement ("Termination
Without Good Reason") is renumbered as Section 5(d).

         6. The following is added as Section 5(e) of the Employment Agreement:

                           (e) If the Executive resigns from employment for any
                  reason, other than Retirement or Disability, during the 90-day
                  period following a Change of Control, such resignation shall
                  be deemed to be a termination by the Executive for Good Reason
                  for purposes of Section 5(c).

                                    In the event of the termination of
                  employment of the Executive by the Company without Cause or by
                  the Executive for Good Reason or resignation following a
                  Change of Control, if the Executive is required, pursuant to
                  Section 4999 of the Internal Revenue Code of 1986, as amended
                  (the "Code"), to pay (through withholding or otherwise) an
                  excise tax on "excess parachute payments" (as defined in
                  Section 280G of the Code), the Company shall pay the Executive
                  the amount necessary to place the Executive in the same
                  after-tax financial position that he would have been in if he
                  had not incurred any excise tax liability under Section 4999
                  of the Code.

         7. The following is added as Section 5(f) of the Employment Agreement:

                           (f) Termination shall be deemed to be a result of a
                  Change of Control (i) if such termination occurs within twelve
                  (12) months following the Change of Control; or (ii) if any
                  change in the Executive's title, reporting relationship,
                  responsibilities or authority as in effect immediately prior
                  to any Change of Control is made within twelve (12) months of
                  such Change of Control and which adversely affects to a
                  material degree his role in the management of the Company; or
                  (iii) if any reduction in the Executive's salary paid to him
                  by the Company as in effect immediately prior to any Change of
                  Control or, if such salary has been subsequently increased at
                  any time or from time to time; any reduction in such increased
                  salary; or (iv) if any termination of the Executive's employee
                  benefit programs, including, but not limited to, any stock
                  option plan, investment plan, savings plan, incentive
                  compensation plan or life insurance, medical plans or
                  disability plans provided by the Company to the Executive and
                  in which the Executive is participating or under which the
                  Executive is covered, all as in effect immediately prior to
                  any Change of Control; or (v) if there is any requirement by
                  the Company that the

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                  Executive's position and principal office be based and located
                  more than twenty (20) miles outside the boundaries of the
                  principal office of the Executive immediately prior to the
                  Change of Control; or (vi) if any failure or refusal of the
                  Company to renew this Employment Agreement under Section 1(b)
                  after any Change of Control shall have occurred.

         8. In all other respects the Employment Agreement is hereby ratified
and affirmed.

                                       CLINTRIALS RESEARCH INC.

                                       By:
                                           -------------------------------------
                                       Title:
                                             -----------------------------------

                                       EXECUTIVE

                                       -----------------------------------------
                                       S. COLIN NEILL

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