Document:

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                                                                   Exhibit 10.40

                             DATED 15th February 2007

                    (1) UNILEVER UK CENTRAL RESOURCES LIMITED

                               (2) UNIPATH LIMITED

                     (3) INVERNESS MEDICAL INNOVATIONS INC.

                                   ----------

                                SUB - UNDERLEASE

                                       OF

                        OFFICE AND PRODUCTION PREMISES AT
                          PRIORY BUSINESS PARK BEDFORD

                                   ----------

                                SLAUGHTER AND MAY
                                 ONE BUNHILL ROW
                                 LONDON EC1Y 8YY
                               TEL: 020 7600 1200
                               FAX: 020 7090 5000
                                  REF: DCRW/SEL
                                   PR061930053
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                                   PARTICULARS

LR1.  DATE OF LEASE: 15th February, 2007

LR2   TITLE        : LR2.1  LANDLORD'S TITLE NUMBER(S)
      NUMBER(S)      BD198122

                     LR2.2  OTHER TITLE NUMBERS
                     BD 196859

LR3.  PARTIES TO   : LANDLORD
      THIS LEASE     UNILVER U.K. CENTRAL RESOURCES LIMITED (registered in
                     England number 00029140) whose registered office is at
                     UNILIEVER HOUSE, BLACKFRIARS, LONDON EC4P 4BQ

                     TENANT

                     UNIPATH LIMITED (registered in England number 00417198)
                     whose registered office is at Stannard Way, Priory Business
                     Park, Bedford MK44 3UP

                     OTHER PARTIES
                     SURETY

                     INVERNESS MEDICAL INNOVATIONS INC. (a corporation
                     registered in the State of Delaware) whose registered
                     office is at 51 Sawyer Road, Suite 200, Waltham,
                     Massachusetts

LR4.  PROPERTY     : Land lying to the north of Stannard Way, Bedford known as
                     Priory Business Park, Bedford MK44 3UP shown edged red on
                     Plan A (as defined in the lease) of the lease.

                     IN THE CASE OF A CONFLICT BETWEEN THIS CLAUSE AND THE
                     REMAINDER OF THIS LEASE THEN, FOR THE PURPOSES OF
                     REGISTRATION, THIS CLAUSE SHALL PREVAIL.

LR5.  PRESCRIBED   : None
      STATEMENTS
      ETC.

LR6.  TERM FOR     : From and including 20 December 2001 to and including 27
      WHICH THE      September 2021.
      PROPERTY IS
      LEASED

LR7.  PREMIUM      : None

LR8.  PROHIBITIONS : This lease contains a provision that prohibits or restricts
      OR             dispositions.
      RESTRICTIONS
      ON DISPOSING
      OF THIS LEASE

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                                 PARTICULARS

LR9   RIGHTS OF    : LR9.1 TENANT'S CONTRACTUAL RIGHTS TO RENEW THIS LEASE, TO
      ACQUISITION    ACQUIRE THE REVERSION OR ANOTHER LEASE OF THE PROPERTY, OR
      ETC.           TO ACQUIRE AN INTEREST IN OTHER LAND

                     None

                     LR9.2 TENANT'S COVENANT TO (OR OFFER TO) SURRENDER THIS
                     LEASE

                     None

                     LR9.3 LANDLORD'S CONTRACTUAL RIGHTS TO ACQUIRE THIS LEASE

                     None

LR10. RESTRICTIVE  : None
      COVENANTS
      GIVEN IN THIS
      LEASE BY THE
      LANDLORD IN
      RESPECT OF
      LAND OTHER
      THAN THE
      PROPERTY

LR11. EASEMENTS    : LR11.1 EASEMENTS GRANTED BY THIS LEASE FOR THE BENEFIT OF
                     THE PROPERTY

                     Clause 4 (referring to the first schedule of the Headlease
                     (as defined in the lease), a copy of which is annexed to
                     the Superior Lease (as defined in the lease, a certified
                     copy of which is annexed to the lease)) LR11.2 EASEMENTS
                     GRANTED OR RESERVED BY THIS LEASE OVER THE PROPERTY FOR THE
                     BENEFIT OF OTHER PROPERTY

                     Clause 4 (referring to first schedule of the lease and to
                     the second schedule of the Headlease (as defined in the
                     lease), a copy of which is annexed to the Superior Lease
                     (as defined in the lease, a certified copy of which is
                     annexed to the lease))

LR12. ESTATE       : None
      RENTCHARGE
      BURDENING
      THE PROPERTY

LR13. APPLICATION  : None
      FOR STANDARD
      FORM OF
      RESTRICTION

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                                 PARTICULARS

LR14. DECLARATION  : Not applicable
      OF TRUST
      WHERE THERE
      IS MORE THAN
      ONE PERSON
      COMPRISING
      THE TENANT
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THIS SUB - UNDERLEASE is made on the ____________ 2006 between (1) the Landlord
specified in the Particulars in Clause 1 below, (2) the Tenant specified in
those Particulars and (3) the Surety specified in those Particulars

THIS DEED WITNESSES AS FOLLOWS:

1.   PARTICULARS

     THE LANDLORD UNILEVER U.K. CENTRAL RESOURCES LIMITED whose registered
     office is at Unilever House Blackfriars London EC4P 4BQ (Company
     Registration no 29140)

     THE TENANT UNIPATH LIMITED whose registered office is at Stannard Way,
     Priory Business Park, Bedford MK44 3UP, (Company Registration no 00417198)

     THE SURETY INVERNESS MEDICAL INNOVATIONS INC. Whose registered office is at
     51 Sawyer Road, Suite 200, Waltham, Massachusetts, being a corporation
     registered in the State of Delaware

     THE ESTATE all that land shown edged yellow on Plan B and known as the
     Priory Business Park Bedford

     THE PREMISES all that land shown edged red on Plan A together with the
     buildings erected thereon.

     TERM COMMENCEMENT DATE the 20th day of December 2001

     CONTRACTUAL TERM a term from and including the Term Commencement Date and
     expiring on 27th September, 2021

     RENT COMMENCEMENT DATE the 20th day of December 2001

     INITIAL RENT One million four hundred and sixty thousand pounds
     (L1,460,000) per year

     REVIEW DATES the 29th September, 2006, 29th September, 2011 and 29th
     September, 2016 and "Review Date" means any one of the review Dates

     INTEREST RATE 3% per year above the base lending rate of Lloyds Bank plc or
     if Lloyds Bank plc shall cease to publish a base lending rate such other
     bank as the Landlord acting reasonably may from time to time nominate in
     writing

     PERMITTED USER Any use or uses within Class B1 and/or Class B8 in the
     schedule to the Town and Country Planning (Use Classes) Order 1987 which is
     in keeping with a high class business park

     DECORATING YEARS are as defined in the Superior Lease

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                                        2

2.   DEFINITIONS

     For the purposes of this lease the terms in the Particulars in Clause 1
     have the meanings therein set out and the following terms shall unless the
     context otherwise admits have the following meanings:

     "ESTATE ROADS" means the roadways shown for the purpose of identification
     only coloured blue on Plan B comprising the two roads linking the Premises
     to the adopted highway

     "GUARANTOR'S COVENANTS" means the covenants in the form specified in the
     Fourth Schedule

     "GROUP COMPANY" of the Landlord or of the Tenant means a company that is a
     member of the same group as the Landlord or the Tenant (where the context
     so requires) within the meaning of Section 42 of the 1954 Act

     "ACCEPTABLE SUBSTITUTE" means a company which is a Group Company of the
     Tenant and which is approved in writing by the Landlord as an acceptable
     assignee of this lease (such approval not to be withheld in the case of a
     company the covenant of which is in the reasonable opinion of the Landlord
     of equal quality to or better quality than that of the Tenant)

     "HEADLEASE" means a lease dated 26th day of November 1996 and made between
     the Bedford Borough Council (1) and Wilson Bowden Properties Limited (2);
     Title Number BD196859 (a copy of which is annexed to the Superior Lease)

     "INSURANCE RENT" means:

     (1)  the insurance premium (without deduction in respect of any commission
          paid or allowed by the insurers to the Landlord in respect of such
          insurance) and tax thereon incurred by the Landlord in relation to
          insuring the Premises against the Insured Risks including those items
          specified in Clause 7.2.2.1 and effecting the insurance against loss
          of rent and service charge specified in Clause 7.2.2.2 and

     (2)  all of any increased premium and tax thereon payable by reason of any
          act or omission of the Tenant

          and such Insurance Rent shall be paid without any deduction or set off
          PROVIDED THAT during the subsistence of the Superior Lease the
          insurance rent shall mean the Insurance Rent payable under the
          Superior Lease

     "INSURED RISKS" means fire lightning explosion aircraft damage (including
     articles dropped from aircraft) riot civil commotion malicious persons
     earthquake storm tempest flood bursting and overflowing of water pipes
     tanks and other apparatus and impact by road vehicles and such other risks
     as the Landlord from time to time in its reasonable discretion thinks fit
     to insure against

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                                        3

     "INTEREST" means interest during the period from the date on which the
     payment is due to the date of payment both before and after any judgement
     at the Interest Rate then prevailing

     "THE 1954 ACT" means the Landlord and Tenant Act 1954 and all statutes
     regulations and orders included by virtue of clause 3.14

     "PERMITTED PART" means (subject to the proviso below) any of the following
     parts of the Premises:

     1.   The Office Building as a whole or

     2.   Any part of the Office Building with a net internal area not less than
          ten thousand (10,000) square feet or

     3.   The Production Building as a whole or

     4.   Any part of the Production Building with a gross internal area of not
          less than twenty thousand (20,000) square feet or

     together (in any such case) with appropriate rights in respect of access
     services and the use of parking spaces and (in the case of all or part of
     the Production Building) the service yard

     "PIPES" means all pipes sewers drains mains ducts conduits gutters
     watercourses wires cables channels flues and all other conducting media and
     includes any fixings louvres cowls and any other ancillary apparatus

     "PLAN A" "PLAN B" and "PLAN C" means the plans attached hereto labelled
     "Plan A" "Plan B" and "Plan C" respectively

     "THE PLANNING ACTS" means the Town and Country Planning Act 1990 and all
     statutes regulations and orders included by virtue of clause 3.14 the
     Planning (Listed Building and Conservation Areas) Act 1990 and the Planning
     (Consequential Provisions) Act 1990 and the Planning and Compensation Act
     1991

     "THE PRODUCTION BUILDING" means that part of the Premises shown for the
     purpose of identification only edged red on Plan C

     "RENT" means the Initial Rent and rent ascertained in accordance with Part
     I of the Second Schedule and such term includes neither the Insurance Rent
     nor the Service Charge but the term "rents" includes Rent the Insurance
     Rent and the Service Charge PROVIDED THAT during the subsistence of the
     Superior Lease the Rent shall be the Rent payable under the Superior Lease

     "THE USER COVENANTS" means the covenants set out in the Third Schedule

     "THE OFFICE BUILDING" means that part of the Premises shown for the purpose
     of identification only edged blue on Plan C

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                                        4

     "THE SERVICES" means the services specified in the Fifth Schedule to the
     Headlease

     "THE SUPERIOR LEASE" means a lease of the Premises dated 11th December,
     1996 between Wilson Bowden Properties Limited (1) and Unilever UK Holdings
     Limited (2) Title number BD198122 (a certified copy of which is annexed to
     this lease)

     "THE SUPERIOR LANDLORD" means the person entitled for the time being to the
     reversion immediately expectant on the determination of the term granted by
     the Superior Lease.

     "SURVEYOR" means any person or firm appointed by or acting for the Landlord
     (including an employee of the Landlord or a Group Company of the Landlord
     and including also the person or firm appointed by the Landlord or the
     Superior Landlord to collect the rents) to perform any of the functions of
     the Surveyor under this lease

3.   INTERPRETATION

     The expressions "the Landlord" and "the Tenant" wherever the context so
     admits include respectively the person for the time being entitled to the
     reversion immediately expectant on the determination of the Term or the
     Tenant's successors in title (as the case may be)

     The expression the "Head Landlord" means the person for the time being
     entitled to the reversion immediately expectant on the determination of the
     term granted by the Headlease

     Where the Landlord or the Tenant for the time being are two or more persons
     obligations expressed or implied to be made by or with such party are
     deemed to be made by or with such persons jointly and severally

     Words importing one gender include all other genders and words importing
     the singular include the plural and vice versa

     The expression "Guarantor" means any person who enters into covenants with
     the Landlord pursuant to clause 5.9.7

     References to "the Premises" (except in relation to Clause 5.9) in the
     absence of any provision to the contrary include any part of the Premises
     (and the expression "the Premises" includes all additions and improvements
     thereto and all Landlord's fixtures and fittings from time to time in or on
     the Premises)

     The expression "the Term" includes the Contractual Term and any period of
     holding-over or extension or continuance of the Contractual Term whether by
     statute or common law

     References to "the last year of the Term" or "the expiration of the Term"
     include the last year of the Term however the Term shall determine (whether
     by effluxion of time or otherwise)

     References to any right of the Landlord to have access to the Premises
     shall be construed as extending to the Superior Landlord and Head Landlord
     and to all persons authorised by the Landlord or Superior Landlord or Head
     Landlord (including agents

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                                        5

     professional advisers contractors workmen and others) where the Headlease
     or Superior Lease grants such rights of access but only on the terms set
     out in this lease

     Any covenant by the Tenant not to do an act or thing shall be deemed to
     include an obligation not knowingly to permit or suffer such act or thing
     to be done by another person

     References to "consent of the Landlord" or words to similar effect mean a
     consent in writing signed by or on behalf of the Landlord and where so
     required under the terms of the Superior Lease the Superior Landlord and
     where so required under the terms of the Headlease the Head Landlord and
     references to "approved" and "authorised" or words to similar effect mean
     (as the case may be) approved or authorised in writing by or on behalf of
     the Landlord or Superior Landlord or Head Landlord

     The terms "the parties" or "party" mean the Landlord and/or the Tenant but
     except where there is an express indication to the contrary exclude any
     Guarantor

     "Development" has the meaning given by the Town and Country Planning Act
     1990 Section 55

     Any references to a specific statute include any statutory extension or
     modification amendment or re-enactment of such statute and any regulations
     or orders made under such statute and any general reference to "statute" or
     "statutes" includes any regulations or orders made under such statute or
     statutes

     References in this lease to any clause sub-clause or schedule without
     further designation shall be construed as a reference to the clause
     sub-clause or schedule to this lease so numbered

     The clause paragraph and schedule headings do not form part of this lease
     and shall not be taken into account in its construction or interpretation

4.   DEMISE

     The Landlord demises to the Tenant with full title guarantee the Premises
     TOGETHER with the rights granted with the Premises in the Headlease but
     EXCEPTING AND RESERVING to the Landlord the rights specified in the First
     Schedule TO HOLD the Premises to the Tenant for the Contractual Term
     SUBJECT to the rights excepted and reserved to the Head Landlord in the
     Headlease YIELDING AND PAYING to the Landlord without any deduction or set
     off:

     the Rent by equal quarterly payments in advance on the usual quarter days
     in every year and proportionately for any period of less than a year

     by way of further rent the Insurance Rent payable on demand in accordance
     with clause 7.3 and by way of further rent the Service Charge payable in
     accordance with clause 5.22

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                                        6

5.   THE TENANT'S COVENANTS

     The Tenant covenants with the Landlord:

5.1  Rents

     To pay the rents on the days and in the manner set out in this lease.

5.2  Outgoings and VAT

     To perform the covenants on the part of the lessee contained in Clause
     3.3.1 and (insofar as liability thereunder arises in connection with an
     application for consent or approval made by the Tenant) Clause 3.3.2 of the
     Headlease and (without prejudice to the foregoing) to pay and to indemnify
     the Landlord against:

5.2.1 all rates taxes duties charges outgoings and obligations whatsoever
     (whether imposed by statute or otherwise and whether of a national or local
     character and whether of the nature of capital or revenue and even though
     of a wholly novel character) which are now or may at any time hereafter be
     assessed charged or imposed upon the Premises or any part thereof or upon
     the owner or occupier in respect thereof including value added tax or any
     other similar tax but otherwise excluding any assessed charged or imposed
     on or by reference to the Rent or any dealing with the Landlord's, Superior
     Landlord's or Head Landlord's reversion)

5.2.2 VAT (or any tax of a similar nature that may be substituted for it or
     levied in addition to it) chargeable in respect of any payment made or to
     be made by the Tenant under any of the terms of or in connection with this
     lease or in respect of any payment made by the Landlord where the Tenant
     agrees in this lease to reimburse the Landlord for such payment and such
     VAT is irrecoverable by the Landlord

5.3  Electricity, gas and other services consumed

     To pay to the suppliers and to indemnify the Landlord against all charges
     for electricity gas and other services consumed or used at or in relation
     to the Premises (including meter rents)

5.4  Repair and cleaning

5.4.1 To repair the Premises and keep them in good and substantial repair
     (excepting damage caused by an Insured Risk save to the extent that the
     insurance money is irrecoverable in consequence of any act or default of
     the Tenant or anyone at the Premises expressly or by implication with the
     Tenant's authority and under the Tenant's control)

5.4.2 To replace from time to time the Landlord's fixtures and fittings in the
     Premises which may be or become beyond repair at any time during or at the
     expiration of the Term

5.4.3 As often as may be reasonably necessary to have professionally treated in
     accordance with the best approved manner for preserving and protecting the
     same all inside and outside parts of the Premises requiring treatment for
     their preservation and protection

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                                        7

5.5  Decoration

     In each of the Decorating Years and in the last year of the Term to
     redecorate the Premises in a good and workmanlike manner and with
     appropriate materials of good quality to the reasonable satisfaction of the
     Surveyor provided that the covenants relating to the last year of the Term
     shall not apply where the Tenant shall have redecorated the Premises less
     than 18 months prior to the expiry of the Term

5.6  Aerials etc.

     Not without the prior written consent of the Landlord which shall not be
     unreasonably withheld or delayed to erect any pole mast or wire or
     satellite dish (whether in connection with telegraphic telephonic radio or
     television communication or otherwise) upon the Premises

5.7  Statutory obligations

5.7.1 At the Tenant's own expense to execute all works and provide and maintain
     all arrangements upon or in respect of the Premises or the use to which the
     Premises are being put that are required in order to comply with the
     requirements of any statute (already or in the future to be passed) or any
     government department, local authority other public or competent authority
     or court of competent jurisdiction regardless of whether such requirements
     are imposed on the lessor the lessee or the occupier

5.7.2 Not to do in or near the Premises any act or thing by reason of which the
     Landlord may under any statute incur have imposed upon it or become liable
     to pay any penalty damages compensation costs charges or expenses

5.7.3 Without prejudice to the generality of the foregoing to comply in all
     respects with the provisions of any statutes and any other obligations
     imposed by law or by any byelaws applicable to the Premises or in regard to
     carrying on the trade or business for the time being carried on the
     Premises

5.7.4 Without prejudice to the generality of the foregoing to observe and
     perform the covenants on the part of the lessee contained in Clauses 3.12
     and 3.13 of the Headlease

5.8  Access of Landlord and notice to repair

5.8.1 To permit the Landlord in accordance with the First Schedule:

5.8.1.1 to enter upon the Premises for the purpose of ascertaining that the
     covenants and conditions of this lease have been observed and performed and

5.8.1.2 to view the state of repair and condition of the Premises

5.8.2 As soon as reasonably practicable to repair cleanse maintain and paint the
     Premises if required by any notice given to the Tenant or left upon the
     Premises by the Landlord specifying any repairs cleaning maintenance or
     painting that the Tenant has failed to

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                                        8

     execute in breach of the terms of this lease and requesting the Tenant
     immediately to execute the same

5.8.3 If within a reasonable period after the service of such a notice the
     Tenant shall not have commenced and be proceeding diligently with the
     execution of the work referred to in the notice or shall fail to complete
     the work within a reasonable period to permit the Landlord to enter the
     Premises to execute such work as may be necessary to remedy the breach of
     covenant and to pay to the Landlord the reasonable cost of so doing and all
     expenses reasonably incurred by the Landlord (including legal costs and
     surveyor's fees) within 14 days of a written demand

5.9  Alienation

5.9.1 Not (save pursuant to a transaction permitted by and effected in
     accordance with the provisions of this lease) to part with the possession
     of the whole or any part of the Premises or permit another to occupy the
     whole or any part of the Premises

5.9.2 Not to assign or charge part only of the Premises and not to underlet part
     save for an underletting of one or more Permitted Parts Provided that there
     shall not at any time be more than four separate occupiers of the Office
     Building and four separate occupiers of the Production Building

5.9.3 Not to create any underletting of one or more Permitted Parts unless it
     makes reasonable arrangements (including the granting and reserving of
     appropriate easements) for (i) access to the part underlet and the
     remaining part or parts of the Premises (ii) the use of parking spaces and
     where appropriate the service yard and (iii) the use of Pipes and other
     services, and it is agreed that in the case of a proposed underletting of
     the entire Office Building (on its own) or the entire Production Building
     (on its own) such arrangements may involve the physical separation of Pipes
     and other services serving the Building being underlet and shall (whether
     or not involving such physical separation) be such as are approved in
     writing by the Landlord or by the Surveyor (such approval not to be
     unreasonably withheld or delayed)

5.9.4 Not to assign underlet or charge the whole of the Premises or grant a
     lease of a Permitted Part without the prior consent of the Landlord, such
     consent not to be unreasonably withheld or delayed (save that such consent
     shall not be withheld in the case of a proposed assignment to a company
     which is an Acceptable Substitute)

5.9.5 Not to assign the Premises or underlet the Premises or any part unless the
     assignee or underlessee first enters into direct covenants with the
     Landlord in a form approved by the Landlord (such approval not to be
     unreasonably withheld or delayed) to perform and observe all the Tenant's
     covenants and all other provisions of this lease (except in the case of any
     underletting the covenant to pay rents) during the residue of the Term (and
     in so far as applicable in respect of an underletting of a Permitted Part)

5.9.6 When making application to the Landlord for consent to underlet to give to
     the Landlord full details of the annual rent and other payments or valuable
     consideration to be paid or given by the undertenant

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                                        9

5.9.7 On a permitted assignment or underletting and if the Landlord shall
     reasonably so require to procure that some guarantor or guarantors
     acceptable to the Landlord (acting reasonably) enter into direct covenants
     with the Landlord in the form of the Guarantor's covenants specified in the
     Fourth Schedule

5.9.8 That each and every permitted underlease shall be granted without any fine
     or premium at a rent not less than the then open market rental value of the
     Premises (or a proportionate part thereof in the case of an underletting of
     a Permitted Part) such rent to be payable in advance on the days on which
     Rent is payable under this lease and shall contain provisions:

5.9.8.1 for the upwards only review of the rent reserved by such underlease on
     the basis (so far as applicable to the part underlet in the case of an
     underlease of a Permitted Part or Parts) and no less frequently than on the
     dates on which the Rent is to be reviewed in this lease (or on such other
     basis as the Landlord may approve in writing such approval not to be
     unreasonably withheld or delayed)

5.9.8.2 prohibiting the undertenant from doing or allowing any act or thing in
     relation to the underlet premises inconsistent with or in breach of the
     provisions of this lease

5.9.8.3 for re-entry by the Tenant on breach of any covenant by the undertenant

5.9.8.4 imposing prohibition against all dispositions of or other dealings
     whatever with the underlet premises other than in accordance with the
     provisions of this lease

5.9.8.5 prohibiting any assignment or underletting of the whole without the
     prior consent of the Landlord under this lease (such consent not to be
     unreasonably withheld or delayed)

5.9.8.6 prohibiting the undertenant from creating a further underlease or
     permitting another to occupy the whole or any part of the Premises except
     as aforesaid

5.9.8.7 imposing in relation to any disposition the same obligations for
     registration with the Landlord as are contained in this lease in relation
     to dispositions by the Tenant and

5.9.9 To use its best endeavours to enforce the performance and observance by
     every such undertenant of the provisions of the underlease and not at any
     time without the consent of the Landlord (such consent not to be
     unreasonably withheld or delayed) either expressly or by implication to
     waive any breach of the covenants or conditions on the part of any
     undertenant or assignee of any underlease or to vary the terms of any
     permitted underlease

5.9.10 In relation to any permitted underlease:

5.9.10.1 to use its best endeavours to ensure that the rent is reviewed in
     accordance with the terms of the underlease

5.9.10.2 to give notice to the Landlord of the details of the determination of
     every rent review within 28 days

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                                       10

5.9.10.3 not to be a party to or permit any agreement or arrangement for
     commutation in whole or part of any annual rent to be reserved on any
     underletting of the Premises or any part thereof in consideration of the
     payment of a lump sum of money or for other valuable consideration

5.9.10.4 that any underlease (except an underlease of the whole Premises or the
     entire Office Building on its own or the entire Production Building on its
     own) shall be excluded from the security of tenure provisions of sections
     24 to 28 of the Landlord and Tenant Act 1954 (as amended) by an Order of
     the appropriate Court and the Tenant shall not grant any such underlease
     until it has produced to the Landlord a copy of the Court Order permitting
     such exclusion

5.9.10.5 not without the prior consent of the Landlord (such consent not to be
     unreasonably withheld or delayed) to accept or agree to accept any
     surrender in respect of any underlease or tenancy that may at any time
     relate to the Premises or any part thereof nor without such consent (not to
     be unreasonably withheld or delayed) to vary or permit or suffer any
     variation of the terms or conditions of any underlease or tenancy or any
     breach by an underlessee of any of the provisions of such underlease or
     tenancy

5.9.11 Within 28 days of any assignment charge underlease or any transmission or
     other devolution relating to the Premises to produce for registration with
     the Landlord's solicitor and the Superior Landlord's solicitors such deed
     or document or a certified copy of it and to pay the Landlord's solicitor's
     and the Superior Landlord's solicitors reasonable charges for the
     registration of every such document such charges not being less than
     L20 (twenty pounds) plus VAT

5.9.12 Notwithstanding clause 5.9.1 the Tenant may share the occupation of the
     whole or any part of the Premises with a company which is a Group Company
     of the Tenant for so long as such company shall remain a Group Company of
     the Tenant and otherwise than in a manner that transfers or creates a legal
     estate

5.9.13 Not to dispose or deal with the Premises otherwise than in accordance
     with the terms of the Superior Lease

5.10 Nuisance

5.10.1 Not to do nor allow to remain upon the Premises anything which may be or
     become or cause or create a legal nuisance or injury or damage to the
     Landlord or the Superior Landlord its tenants or the owners or occupiers of
     adjacent or neighbouring premises on the Estate

5.10.2 Not to use the Premises for a sale by auction or for any dangerous
     noxious noisy or offensive trade business manufacture or occupation nor for
     any illegal or immoral act or purpose nor to permit the emission of smoke

5.10.3 If the Landlord shall abate any nuisance for which the Tenant is
     responsible to pay all costs charges and expenses reasonably and properly
     incurred in abating such nuisance and executing all such works as may be
     necessary for such purpose whether or not required by a notice served by
     any local or other authority

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                                       11

5.10.4 To provide and maintain receptacles for the clean and efficient removal
     of waste materials from the Premises

5.11 Landlord's costs

     To pay to the Landlord on an indemnity basis all reasonable and proper
     costs fees charges disbursements and expenses (including without prejudice
     to the generality of the above those payable to counsel solicitors
     surveyors and bailiffs) reasonably and properly incurred by the Landlord in
     relation to or incidental to:

5.11.1 every application made by the Tenant for a consent or licence required by
     the provisions of this lease whether such consent or licence is granted or
     refused or proffered subject to any lawful qualification or condition or
     whether the application is withdrawn unless such refusal qualification or
     condition is unlawful whether because it is unreasonable or otherwise

5.11.2 the preparation and service of a notice under the Law of Property Act
     1925 Section 146 or incurred by or in reasonable contemplation of
     proceedings under Sections 146 or 147 of that Act notwithstanding that
     forfeiture is avoided otherwise than by relief granted by the court

5.11.3 the recovery or attempted recovery of arrears of rent or arrears of other
     sums due from the Tenant and

5.11.4 the preparation and service of a schedule of dilapidations for which the
     Tenant is liable and whether served during or within 3 months or after the
     expiration of the Term

5.12 The Planning Acts

5.12.1 Not to commit in relation to the Premises any breach of planning control
     (such term to be construed in the way in which it is used in the Planning
     Acts)

5.12.2 Not without the consent in writing of the Landlord (such consent not to
     be unreasonably withheld or delayed) to apply for planning permission to
     carry out any Development in or upon the Premises and at the expense of the
     Tenant to supply the Landlord with a copy of any application for planning
     permission together with such plans and other documents as the Landlord may
     reasonably require and to supply prior to the commencement of any
     Development a copy of any planning permission granted to the Tenant and not
     to commence any Development without the approval in writing of the Landlord
     (such approval not to be unreasonably withheld or delayed) of the
     conditions of such consent

5.12.3 To pay and satisfy any charge that may be imposed upon any breach by the
     Tenant of planning control or otherwise under the Planning Acts

5.12.4 Unless the Landlord shall otherwise direct to carry out and complete
     before the expiry of the Term any works required to be carried out to or in
     the Premises as a condition of any planning permission which may have been
     granted during the Term and implemented or partially implemented by the
     Tenant irrespective of the date by which such works were required to be
     carried out

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                                       12

5.13 Plans, documents and information

     If called upon to do so to produce to the Landlord or the Surveyor all
     plans documents and other evidence as the Landlord may reasonably require
     in order to satisfy itself that the provisions of Clause 5.12 have been
     complied with

5.14 Indemnities

     To be responsible for and to keep the Landlord fully indemnified against
     all damage damages losses costs expenses actions demands proceedings claims
     and liabilities made against or suffered or incurred by the Landlord
     arising directly or indirectly out of any breach or non-observance by the
     Tenant of the covenants conditions or other provisions of this lease or any
     of the matters to which this demise is subject

5.15 Encroachments

5.15.1 Not to stop up darken or obstruct any windows or light belonging to the
     Premises

5.15.2 To take all reasonable steps to prevent any new window light opening
     doorway path passage pipe or other encroachment or easement being made or
     acquired in against out of or upon the Premises and to notify the Landlord
     immediately if any such encroachment or easement shall be made or acquired
     (or attempted to be made or acquired) and at the request and cost of the
     Landlord to adopt such means as shall reasonably be required to prevent
     such encroachment or the acquisition of any such easement

5.16 Yield up

     At the expiration of the Term:

5.16.1 to yield up the Premises in accordance with the terms of this lease
     (damage caused by any Insured Risks excepted save insofar as payment of the
     insurance money is refused due to some act or default of the Tenant or
     anyone at the Premises expressly or by implication with the Tenant's
     authority and under the Tenant's control)

5.16.2 if so required by the Landlord (i) to remove any alterations made
     pursuant to paragraph 2.1 of the Third Schedule and (ii) to reinstate the
     premises in accordance with the Notional Office Building Specification and
     Notional Production Building Specification attached to the Superior Lease
     as qualified by the Reinstatement Provisions attached to the Superior Lease
     such reinstatement to be carried out to the reasonable satisfaction of the
     Surveyor

5.16.3 to remove all signs erected by the Tenant in upon or near the Premises
     and immediately to make good any damage caused by such removal

5.16.4 to give up all keys of the Premises to the Landlord

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                                       13

5.16 Interest on arrears

     If the Tenant shall fail to pay the rents or any other sum due under this
     lease within 7 days of the date due (whether in the case of rent formally
     demanded or not) the Tenant (here meaning only the Tenant in whom this
     lease is vested at the relevant time and not its predecessors in title)
     shall pay to the Landlord Interest on the rents or other sum from the date
     when they were due to the date on which they are paid and such Interest
     shall be deemed to be rent due to the Landlord

5.17 Statutory notices etc

     To give full particulars to the Landlord, Superior Landlord and Head
     Landlord of any notice direction order or proposal for the Premises made
     given or issued to the Tenant by any local or public authority within 7
     days of receipt and if so required by the Landlord, Superior Landlord and
     Head Landlord to produce it to the Landlord, Superior Landlord and Head
     Landlord and without delay to take all necessary steps to comply with the
     notice direction or order and at the Landlord's. cost and reasonable
     request to make or join with the Landlord in making such objection or
     representation against or in respect of any notice direction order or
     proposal as the Landlord shall deem expedient unless it would be adverse to
     the Tenant's commercial interests

5.18 Re-letting Sale of reversion etc

5.19.1 To permit the Landlord in the case of a proposed sale of the Landlord's
     interest or any other superior interest at any time during the Term and in
     the case of reletting the Premises during the last twelve months before the
     end of the Term to fit in a conspicuous position on the Premises (but not
     so as to obscure or obstruct any windows or doors) a notice board for such
     reletting or sale of the same and not to take down or obscure the said
     notice board

5.19.2 At all times during the Term to permit any person authorised by order in
     writing of the Landlord or its agents on reasonable prior notice to view
     and take measurements of the Premises at reasonable hours in the daytime

5.19 Defective premises

     To give notice to the Landlord, Superior Landlord and Head Landlord of any
     defect in the Premises which might give rise to an obligation on the
     Landlord and/or Superior Landlord and/or the Head Landlord to do or refrain
     from doing any act or thing in order to comply with the provisions of this
     lease or the duty of care imposed on the Landlord pursuant to the Defective
     Premises Act 1972 or otherwise and at all times to display and maintain all
     notices which the Landlord may from time to time reasonably require to be
     displayed at the Premises in connection therewith

5.20 Landlord's rights

     To permit the Landlord at all times during the Term to exercise without
     interruption or interference in accordance with the First Schedule any of
     the rights granted or reserved to it by virtue of the provisions of this
     lease

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                                       14

5.22 The User Covenants Regulations and Service Charge

5.22.1 To observe and perform the User Covenants and the covenants on the part
     of the lessee contained in Clauses 3.5 and 3.9 of the Headlease

5.22.2 To comply with the regulations in the Fourth Schedule to the Headlease
     and to use reasonable endeavours to ensure that other occupiers of the
     Premises or any part thereof do so

5.22.3 To pay the service charge (pursuant to the terms of the Third Schedule to
     the Headlease) to the Landlord or if the Landlord shall direct to the
     Superior Landlord or Head Landlord within 10 days of receipt from the
     Landlord of a service charge statement compiled by the Head Landlord in
     accordance with the Third Schedule to the Headlease

5.23 Headlease Covenants

     To indemnify the Landlord against any costs claims or expenses in respect
     of any breach of the terms of the Headlease resulting from any breach on
     the part of the Tenant of any of its covenants or obligations or conditions
     contained in this lease

5.24 Superior Lease Covenants

     To perform and observe all the covenants (excepting obligations on the
     lessee to make payments to the lessor under the Superior Lease) on the part
     of the lessee contained in the Superior Lease, and to indemnify the
     Landlord against any costs claims or expenses resulting from any breach on
     the part of the Tenant of this covenant.

6.   THE LANDLORD'S COVENANTS

     The Landlord covenants with the Tenant:

6.1  Quiet enjoyment

     To permit the Tenant peaceably and quietly to hold and enjoy the Premises
     without any interruption or disturbance from or by the Landlord or any
     person claiming through under or in trust for the Landlord or by title
     paramount

6.2  Superior Lease

6.2.1 Promptly to pay the basic rent reserved by and to observe and perform and
     indemnify of any breach of the covenants on the part of the lessee
     contained in the Superior Lease or to procure that this is done except to
     the extent that such covenants are within the scope of the covenants on the
     part of the Tenant contained in this lease

6.2.2 To pay the service charge to the Superior Landlord and produce a copy of
     the receipted account to the Tenant or to procure that this is done

6.2.3 Subject to the Tenant indemnifying the Landlord against the reasonable and
     proper costs incurred by the Landlord, at the reasonable request of the
     Tenant:

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                                       15

6.2.3.1 to take such action as the Tenant reasonably deems appropriate to
     enforce the obligations on the part of the Superior Landlord contained in
     the Superior Lease and

6.2.3.2 to use its best endeavours to obtain the consent of the Superior
     Landlord to any matter for which the Tenant reasonably requires such
     consent or to procure that this is done

7.   INSURANCE

7.1  Landlord to insure

     The Landlord covenants with the Tenant to:

7.1.1 insure the Premises save insofar as such insurance shall be vitiated by
     any act of the Tenant or by anyone at the Premises expressly or by
     implication with the Tenant's authority and under the Tenant's control and

7.1.2 produce to the Tenant on reasonable demand (and not more than once in any
     12 month period) reasonable evidence of the terms of the policy and the
     fact that the last premium has been paid and

7.1.3 notify the Tenant of any material change in the risks covered by the
     policy from time to time

     or to procure that this is done

7.2  Details of the Insurance

     The Landlord shall procure that insurance shall be effected:

7.2.1 in such substantial and reputable insurance office or with such
     underwriters and through such agency as the Landlord may from time to time
     decide

7.2.2 for the following sums:

7.2.2.1 such sum as shall be the full cost of rebuilding and reinstatement
     including architects' surveyors' and other professional fees payable upon
     any application for planning permission or other permits or consents that
     may be required in relation to the rebuilding or reinstatement of the
     Premises the cost of debris removal demolition site clearance and any works
     that may be required by statute and incidental expenses and

7.2.2.2 the loss of Rent and Service Charge payable under this lease from time
     to time (having regard to any review of rent which may become due under
     this lease) for 3 years

7.2.3 against damage or destruction by the Insured Risks upon reasonable terms
     and at reasonable rates with an insurer of repute and subject to such
     excesses exclusions or limitations as are normal for premises similar to
     the Premises and within the same locality

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                                       16

7.3  Payment of Insurance Rent

7.3.1 The Tenant shall pay the Insurance Rent on the date of this lease for the
     period from and including the date hereof to the day before the next policy
     renewal date and subsequently the Tenant shall pay the Insurance Rent on
     demand and (if so demanded) in advance but not more than one month in
     advance of the policy renewal date

7.3.2 The Landlord will if practicable give to the Tenant reasonable notice of
     the amount of the premium for each year and if at any renewal the Tenant
     notifies the Landlord in writing that the Tenant believes that the premium
     is excessive the Landlord will pass to the insurers or the brokers through
     which any such insurance is arranged any representations which the Tenant
     may make and if the Tenant so requests will take reasonable steps (at the
     cost of the Tenant) to secure a reduction in the premium for the ensuing
     year or procure that this is done

7.4  Suspension of Rent

7.4.1 If and whenever during the Term the Premises or any part are damaged or
     destroyed by any of the Insured Risks so that the Premises or any part of
     them are unfit for occupation or use then to the extent that payment of the
     insurance money is not refused in whole or in part by reason of any act or
     default of the Tenant or anyone at the Premises expressly or by implication
     with the Tenant's authority and under the Tenant's control the provisions
     of clause 7.4.2 shall have effect

7.4.2 When the circumstances contemplated in clause 7.4.1 arise the Rent or a
     fair proportion of the Rent according to the nature and the extent of the
     damage sustained shall cease to be payable until the Premises or the
     damaged parts shall have been rebuilt or reinstated so that the Premises or
     the affected part are made fit for occupation or use (any dispute as to
     such proportion or the period during which the Rent shall cease to be
     payable to be determined in accordance with the Arbitration Acts 1950 to
     1979 by an arbitrator to be appointed by agreement between the parties or
     in default by the President for the time being of the Royal Institution of
     Chartered Surveyors upon the application of either party)

7.5  Reinstatement and termination if prevented

7.5.1 If and whenever during the Term the Premises or any part are damaged or
     destroyed by any of the Insured Risks then to the extent that the payment
     of the insurance money is not refused in whole or in part by reason of any
     act or default of the Tenant or anyone at the Premises expressly or by
     implication with the Tenant's authority and under the Tenant's control the
     Landlord shall use its best endeavours to obtain all planning permissions
     or other permits and consents that may be required under the Planning Acts
     or other statutes (if any) or under the Headlease or procure that this is
     done to enable the Landlord to rebuild and reinstate or to procure the
     rebuilding or reinstatement of the Premises or such part or parts so
     damaged or destroyed ("Permissions") and the Tenant shall give the Landlord
     such assistance and support in that regard as the Landlord requires

7.5.2 Subject to the provisions of clauses 7.5.3 and 7.5.4 and only to the
     extent specified in clause 7.5.1 the Landlord shall as soon as the
     Permissions have been obtained or as

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                                       17

     soon as reasonably practicable where no Permissions are required apply all
     money received in respect of such insurance (except sums in respect of loss
     of Rent) in rebuilding or reinstating or procuring that such monies are
     applied to rebuild or reinstate the Premises so destroyed or damaged making
     up any difference between the cost of rebuilding and reinstating and the
     money received out of the Landlord's own money PROVIDED THAT the Landlord
     shall be entitled to rebuild or reinstate or to procure the rebuilding or
     reinstatement of the Premises either in the form in which they were
     immediately before the occurrence of the destruction or damage or in that
     form with such modifications as:

7.5.2.1 may be required by any competent authority as a condition of the grant
     of any of the Permissions and/or

7.5.2.2 the Landlord may reasonably make to reflect then current good building
     practice

     but so that the Landlord shall in any event provide in the Premises as
     rebuilt and reinstated accommodation for the Tenant no less convenient and
     commodious and ancillary facilities no less convenient than those which
     existed immediately before the occurrence of the destruction or damage

7.5.3 For the purposes of clause 7.5.4 the expression "Supervening Events"
     means:

7.5.3.1 the Landlord has failed despite using its best endeavours to obtain the
     Permissions

7.5.3.2 any of the Permissions have been granted subject to a lawful condition
     with which it would in all the circumstances be unreasonable to expect the
     Landlord to comply

7.5.3.3 the rebuilding or reinstating is prevented by war act of God Government
     action strike lock-out or

7.5.3.4 any other circumstances beyond the control of the Landlord

7.5.4 The Landlord shall not be liable to rebuild or reinstate the Premises or
     to procure the same if and for so long as such rebuilding or reinstating is
     prevented by Supervening Events

7.5.5 If upon the expiry of a period of 3 years commencing on the date of the
     damage or destruction the Premises (or a substantial part thereof) have not
     been rebuilt or reinstated so that the Premises are fit for the Tenant's
     occupation and use either the Landlord or the Tenant may by notice served
     on the other at any time within 6 months after the expiry of such period of
     3 years (but before the Premises have been rendered fit for occupation and
     use) invoke the provisions of clause 7.5.6 PROVIDED THAT the Landlord shall
     only be entitled to invoke the provisions of clause 7.5.6 in the
     circumstances referred to in clause 7.5.4 and the Tenant shall not be
     entitled to invoke the provisions of clause 7.5.6 if any insurance money is
     wholly or substantially irrecoverable by reason of any act or default of
     the Tenant or anyone at the Premises expressly or by implication with the
     Tenant's authority

7.5.6 Upon service of a notice in accordance with clause 7.5.5:

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                                       18

7.5.6.1 the Term will absolutely cease but without prejudice to any rights or
     remedies that may have accrued to either party against the other

7.5.6.2 all money received in respect of the insurance effected by the Landlord
     pursuant to this clause 7 shall belong to the Landlord

7.6  Tenant's insurance covenants

     The Tenant covenants with the Landlord:

7.6.1 to comply with all the requirements of the insurers but if the Tenant
     shall notify the Landlord that the Tenant considers any such requirements
     unreasonable the Landlord shall so inform the insurers or the brokers
     through which the insurance is arranged and if the Tenant's objections are
     reasonable the Landlord shall use reasonable endeavours to persuade the
     insurers to drop the requirement to which the Tenant objects

7.6.2 not to do or omit anything that could cause any policy of insurance on or
     in relation to the Premises to become void or voidable wholly or in part
     nor (unless the Tenant shall pay the increased premium) anything by which
     additional insurance premiums may become payable

7.6.3 to keep the Premises supplied with adequate fire fighting equipment
     (including any which the fire authority may require or which the insurers
     or the Landlord may reasonably require) and to maintain such equipment to
     their satisfaction and in efficient working order and at least once in
     every 6 months to cause any sprinkler system and other fire fighting
     equipment to be inspected by a competent person

7.6.4 not to store or bring onto the Premises any article substance or liquid of
     a specially combustible inflammable or explosive nature (save in respect of
     the Permitted User and then only to the extent that such substances are
     properly stored displayed and maintained to the reasonable satisfaction of
     the Landlord and Superior Landlord) and to comply with the requirements of
     the fire authority and the reasonable requirements of the Landlord as to
     fire precautions relating to the Premises

7.6.5 not to obstruct the access to any fire equipment or the means of escape
     from the Premises nor to lock any fire door while the Premises are occupied

7.6.6 to give notice to the Landlord immediately upon the Tenant becoming aware
     of the happening of any event which might affect any insurance policy on or
     relating to the Premises or upon the happening of any event against which
     the Landlord may have insured under this lease

7.6.7 if at any time the Tenant shall be entitled to the benefit of any
     insurance on the Premises (which is not effected or maintained in pursuance
     of any obligation contained in this lease) to apply all money received by
     virtue of such insurance in making good the loss or damage in respect of
     which such money shall have been received

7.6.8 if and whenever during the Term the Premises or any part of them are
     damaged or destroyed by an Insured Risk and the insurance money under the
     policy of insurance effected by the Landlord pursuant to its obligations
     contained in this lease is by reason

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                                       19

     of any act or default of the Tenant or anyone at the Premises expressly or
     by implication with the Tenant's authority and under the Tenant's control
     wholly or partially irrecoverable immediately in every such case (at the
     option of the Landlord) either:

7.6.8.1 to rebuild and reinstate at its own expense the Premises or the part
     destroyed or damaged to the reasonable satisfaction and under the
     supervision of the Surveyor the Tenant being allowed towards the expenses
     of so doing upon such rebuilding and reinstatement being completed the
     amount (if any) actually received in respect of such destruction or damage
     under any such insurance policy or

7.6.8.2 to pay to the Landlord on demand the amount of such insurance money so
     irrecoverable together with Interest on such irrecoverable money from the
     date when the same would otherwise have been received by the Landlord to
     the date of payment by the Tenant

8.   VAT

     It is agreed that all rents and other payments whatsoever due from the
     Tenant hereunder shall be exclusive of Value Added Tax and the Tenant
     covenants with the Landlord that the Tenant shall in addition (upon receipt
     of a valid Value Added Tax invoice addressed to the Tenant) pay the full
     amount of any Value Added Tax or other similar tax for which the Landlord
     or other the person entitled to such rents or other payments shall from
     time to time be accountable in respect thereof

9.   PROVISOS

9.1  Re-entry

     If and whenever during the Term:

9.1.1 the rents (or any of them or any part of them) under this lease are
     outstanding for 21 days after becoming due whether (in the case of Rent)
     formally demanded or not or

9.1.2 there is a breach by the Tenant or any Guarantor for the time being of any
     covenant or other term of this lease or any document expressed to be
     supplemental to this lease or

9.1.3 an individual Tenant or any Guarantor for the time being becomes bankrupt
     or

9.1.4 a company Tenant or company Guarantor:

9.1.4.1 enters into liquidation whether compulsory or voluntary (but not if the
     liquidation is for amalgamation or reconstruction of a solvent company) or

9.1.4.2 has a receiver or administrative receiver appointed or

9.1.4.3 summons a meeting of its creditors or any of them under Part 1 of the
     Insolvency Act 1986 ("the 1986 Act") or

9.1.4.4 suffers a petition for an administration order or winding-up order in
     respect of it to be filed in Court or has an administration order or
     winding-up order made in respect of it

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                                       20

9.1.4.5 summons a meeting of its creditors under Section 98 of the 1986 Act; or

9.1.5 the Tenant or any Guarantor for the time being enters into an arrangement
     for the benefit of its creditors

     then the Landlord may re-enter the Premises (or any part of them in the
     name of the whole) at any time (and even if any previous right of re-entry
     has been waived) and then the Term will absolutely cease but without
     prejudice to any rights or remedies which may have accrued to the Landlord
     against the Tenant or to the Tenant against the Landlord in respect of any
     breach of covenant or other term of this lease (including the breach in
     respect of which the re-entry is made)

9.2  Rights easements etc

     The operation of the Law of Property Act 1925 Section 62 shall be excluded
     from this lease and the only rights granted to the Tenant are those
     expressly set out in this lease and the Tenant shall not by virtue of this
     lease be deemed to have acquired or become entitled by any means whatever
     to any easement from or over or affecting the Estate or any other land or
     premises now or at any time after the date of this lease belonging to the
     Landlord, the Superior Landlord or the Head Landlord and not comprised in
     this lease

9.3  Accidents

     The Landlord, Superior Landlord and the Head Landlord shall not be
     responsible to the Tenant or to anyone at the Premises or using the Estate
     Roads expressly or by implication with the Tenant's authority for any
     accident happening or injury suffered or for any damage to or loss of any
     chattel sustained in the Premises or the Estate unless due to the act
     neglect or default of the Landlord or covered by the Landlord's insurance

9.4  Perpetuity period

     The perpetuity period applicable to this lease shall be 80 years from the
     commencement of the Contractual Term and whenever in this lease either
     party is granted a future interest in property there shall be deemed to be
     included in respect of every such grant a provision requiring that future
     interest to vest within the stated period and for it to be void for
     remoteness if it shall not have so vested

9.5  Exclusion of use warranty

     Nothing in this lease or in any consent granted by the Landlord under this
     lease shall imply or warrant that the Premises may lawfully be used under
     the Planning Acts for the purpose authorised in this lease (or any purpose
     subsequently authorised)

9.6  Entire understanding

     This lease embodies the entire understanding of the parties relating to the
     Premises and to all the matters dealt with by any of the provisions of this
     lease

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                                       21

9.7  Licences etc under hand

     Whilst the Landlord is a limited company or other corporation all licences
     consents approvals and notices required to be given by the Landlord shall
     be sufficiently given if given under the hand of a director the secretary
     or other duly authorised officer of the Landlord

9.8  Service of notices

     The provisions of the Law of Property Act 1925 Section 196 as amended by
     the Recorded Delivery Service Act 1962 shall apply to the giving and
     service of all notices and documents under or in connection with this lease
     except that Section 196 shall be deemed to be amended as follows:

9.8.1 the final words of Section 196 (4) ____ and that service ____________ be
     delivered shall be deleted and there shall be substituted ____ and that
     service shall be deemed to be made on the second Working Day after the
     registered letter has been posted ("Working Day" meaning any day from
     Monday to Friday (inclusive) other than Christmas Day Good Friday and any
     statutory bank or public holiday)

9.8.2 any notice or document shall also be sufficiently served if sent by telex
     facsimile transmission to the party to be served and that service shall be
     deemed to be made on the day of transmission if transmitted before 4 pm on
     a Working Day but otherwise on the next following Working Day (as defined
     above)

     and in this clause 9.8 "party" includes any Guarantor.

10.  RIGHT TO BREAK

10.1 Subject to the condition specified in Clause 10.2 below the Tenant may
     terminate this Lease on 29th September, 2011 ("the Break Date") by giving
     to the Landlord no less than 14 months' prior written notice ("a Notice to
     Break") expiring on the Break Date (time to be of the essence) and (subject
     to that condition) if a Notice to Break is given this lease shall on the
     Break Date forthwith cease and determine without prejudice to any right and
     remedy of either party against the other in respect of any antecedent
     breach and without prejudice to the provisions of Clauses 10.3 and 10.4
     below

10.2 The condition specified in Clause 10.1 above is that either:

10.2.1 The Tenant gives vacant possession of the whole of the Premises to the
     Landlord or

10.2.2 The Tenant has taken all reasonable steps to obtain such vacant
     possession and the Tenant is entitled to such vacant possession and upon
     the termination of the Lease on the Break Date the Landlord will
     immediately be entitled to vacant possession

10.3 If this lease is determined on the Break Date the Tenant shall pay to the
     Landlord on the Break Date a sum equal to 1.5 years' Rent (which for this
     purpose shall mean Rent at the yearly rate at which it was payable
     immediately before the Break Date) plus VAT

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                                       22

10.4 If the Tenant having given a Notice to Break does not give vacant
     possession of the whole of the Premises at the Break Date the Tenant will
     indemnify the Landlord against all costs and expenses properly incurred by
     the Landlord in obtaining vacant possession.

11.  SURETY'S COVENANTS

11.1 Payment

     The Surety covenants with the Landlord in respect of the period ending on
     the date on which Unipath Limited is released by virtue of the Landlord and
     Tenant (Covenants) Act 1995 that:

          (i)  the Tenant will throughout the term as well after as before any
               disclaimer of this lease pay the rents reserved by this lease as
               from time to time reviewed and will observe and perform the
               Tenant's covenants in this lease;

          (ii) in case of default or delay on the part of the Tenant the Surety
               will by way of primary obligation and not merely as a guarantor
               or as collateral to the Tenant's obligation pay to the Landlord
               any sum which ought to be paid and make good any breaches of the
               Tenant's covenants in this lease including all losses, damages,
               costs and expenses arising or incurred by the Landlord; and

          (iii) the Surety will indemnify the Landlord against all costs arising
               from or in contemplation of the enforcement of the Surety's
               covenants in this lease.

11.2 New lease

     (A)  The Surety further covenants with the Landlord that in the event of
          forfeiture of this lease or if the Tenant is dissolved or enters into
          liquidation and the Crown or the liquidator disclaims this lease, then
          the Surety or such of the persons for the time being comprising the
          Surety as the Landlord may choose shall within three months of the
          forfeiture or disclaimer upon being required so to do by the Landlord
          by written notice given at any time take up a new lease of the demised
          premises and deliver a duly executed counterpart to the Landlord upon
          the same terms as this lease save that:

          (i)  such lease will be subject to and with the benefit of this lease
               if and so far as it is subsisting;

          (ii) the term will commence on the date of such notice and expire on
               the date the Term specified in the Particulars of this lease is
               due to expire or would have expired but for its having already
               ended; and

          (iii) so far as there are outstanding breaches of the Tenant's
               covenants in this lease, the Landlord may require without
               prejudice to its other

<PAGE>

                                       23

               remedies that such lease contains a covenant that they will be
               remedied promptly at the cost of the Surety to the satisfaction
               of the Landlord.

     (B)  The Surety will:

          (i)  join in any consent, approval or licence required by any other
               person interested in the demised premises in connection with the
               grant of the lease; and

          (ii) on completion of such lease indemnify the Landlord against its
               costs in connection with the obtaining of any such consent,
               approval or licence and the grant of the lease.

11.3 Ranking of claims

     (A)  The Surety will only be entitled to enforce its rights in respect of
          any sums it pays or liabilities it incurs under the Surety's covenants
          in this lease or in any new lease it is required to take up under this
          schedule after the Surety's obligations under all such covenants have
          been observed, performed and discharged in full and the Surety shall
          not:

          (i)  seek to recover from the Tenant in competition with the Landlord
               whether directly or by way of set-off, lien, counter-claim or
               otherwise or accept any money or other property or security or
               exercise any rights in respect of any sum which may be or become
               due to the Surety on account of failure by the Tenant to observe,
               perform or discharge the Tenant's covenants in this lease;

          (ii) claim, prove for or accept any payment in any composition by or
               winding up or liquidation of the Tenant or any third party in
               competition with the Landlord for any amount owing to the Surety
               on any account.

     (B)  The Surety warrants to the Landlord that it has not taken and will not
          take any security from the Tenant or any third party in connection
          with the Surety's covenants in this lease or in any new lease it is
          required to take up under this schedule and any such security so taken
          shall be held in trust for the Landlord as security for the respective
          liabilities of the Surety and the Tenant.

11.4 Sole or principal debtor

     Without prejudice to the rights of the Landlord against the Tenant as
     principal the Surety as a separate and independent stipulation agrees that
     any liability mentioned in this schedule which may not be recoverable on
     the footing of a guarantee whether by reason of any legal limitation,
     disability or incapacity on or of the Tenant or any other fact or
     circumstance and whether known to the Landlord or not will nevertheless be
     recoverable from the Surety as though it had been incurred by the Surety
     and the Surety was the sole or principal debtor in respect of it and will
     be paid by the Surety on demand together with interest (as well after as
     before any judgment) at the rate of four per centum per annum above the
     base rate of National Westminster Bank Plc from time to time from the date
     of demand until payment.

<PAGE>

                                       24

11.5 Immediate recourse

     The provisions of this schedule are in addition to and not in substitution
     for any other rights which the Landlord may have and may be enforced
     against the Surety whether or not recourse has been had to any such rights
     and whether or not any steps or proceedings have been taken against the
     Tenant.

11.6 Obligations to subsist

     The rights of the Landlord and the obligations of the Surety will continue
     to subsist notwithstanding:

          (i)  the neglect or forbearance of the Landlord in endeavouring to
               obtain payment of the rents reserved by this lease or enforcing
               the observance and performance of the Tenant's covenants in this
               lease whether from or by the Tenant, the Surety or any other
               person;

          (ii) any time which may be given by the Landlord for the payment of
               the rents reserved by this lease or the observance and
               performance of the Tenant's covenants in this lease whether from
               or by the Tenant, the Surety or any other person;

          (iii) the demand or acceptance of sums at a time when the Landlord has
               notice of a breach of the Tenant's covenants in this lease;

          (iv) the refusal by the Landlord to accept rent tendered by or on
               behalf of the Tenant, the Surety or any other person;

          (v)  the grant of any licence, consent or approval by the Landlord;

          (vi) any variation of this lease agreed between the Landlord and the
               Tenant for the time being save as provided in Section 18 of the
               Landlord and Tenant (Covenants) Act 1995;

          (vii) the disposition of the Landlord's reversion or any part of it;

          (viii) the release of any one or more persons for the time being
               constituting the Tenant or the Surety; or

          (ix) any other act omission, matter or thing by which (but for this
               provision) the Tenant or the Surety would be exonerated either
               wholly or in part from its obligations to the Landlord other than
               a release under seal given by the Landlord.

11.7 Supplemental

     If so reasonably required by the Landlord the Surety will join in any
     instrument made under or supplemental to this lease for the purpose of
     acknowledging it is bound by it and that the obligations in this clause
     extend to it.

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                                       25

11.8 Statutory avoidance

     No assurance, security or payment which may be avoided under any Statute
     nor any release, settlement or discharge of the Surety which may have been
     given or made on the faith of any such assurance, security or payment shall
     prejudice or affect the right of the Landlord to recover from the Surety to
     the full extent of this clause as if such release, settlement or discharge
     had not occurred.

11.9 Agent for Service

     (A)  The Surety irrevocably appoints General Counsel, with a copy to the
          Managing Director of Unipath Limited, both of of Stannard Way, Priory
          Business Park, Bedford MK44 3UP to be its agent for the receipt of
          Service Documents. It agrees that any Service Document may be
          effectively served on it in connection with Proceedings in England and
          Wales by service on its agent effected in any manner permitted by the
          Civil Procedure Rules.

     (B)  If the agent at any time ceases for any reason to act as such, the
          Surety shall appoint a replacement agent having an address for service
          in England or Wales and shall notify the Landlord of the name and
          address of the replacement agent. Failing such appointment and
          notification, the Landlord shall be entitled by notice to the Surety
          to appoint a replacement agent to act on behalf of the Surety. The
          provisions of this clause applying to service on an agent apply
          equally to service on a replacement agent.

     (C)  A copy of any Service Document served on an agent shall be sent by
          post to the Surety. Failure or delay in so doing shall not prejudice
          the effectiveness of service of the Service Document.

     (D)  "SERVICE DOCUMENT" means a claim form, application notice, order,
          judgment or other document relating to any Proceedings.

12.  GOVERNING LAW

     This lease is to be governed by and construed in accordance with English
     Law.

13.  JURISDICTION

13.1 The courts of England are to have exclusive jurisdiction to settle any
     dispute arising out of or in connection with this lease. Any proceeding,
     suit or action arising out of or in connection with this lease
     (PROCEEDINGS) shall be brought only in the courts of England. This clause
     is not concluded for the benefit of any party or parties to this lease.

13.2 Each party waives (and agrees not to raise) any objection, on the ground of
     forum non conveniens or on any other ground, to the taking of proceedings
     in the courts of England. Each party also agrees that a judgment against it
     in Proceedings brought in England shall be conclusive and binding upon it
     and may be enforced in any other jurisdiction.

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                                       26

13.3 Each party irrevocably submits and agrees to submit to the jurisdiction of
     the courts of England.

14.  AGREEMENT

     This lease has been entered into pursuant to an agreement dated 20th
     December 2001.

IN WITNESS of which the parties hereto have executed this instrument as their
Deed and it is the parties' intention that this Deed be delivered and is hereby
delivered on the date first above written

<PAGE>

                                       27

                                 FIRST SCHEDULE

                                 RIGHTS RESERVED

1    The right at reasonable times and upon reasonable prior written notice
     (except in cases of emergency) to enter the Premises:

1.1  to inspect the condition and the state of repair of the Premises

1.2  to take schedules or inventories of fixtures and other items to be yielded
     up on the expiry of the Term and

1.3  to exercise any of the rights granted to the Landlord by this lease

2    The right with the Surveyor and any person acting as the third party
     determining the Rent in default of agreement between the parties under the
     provisions for rent review contained in this lease at convenient hours and
     on reasonable prior notice to enter and to inspect and measure the Premises
     for all purposes connected with any pending or intended step under the 1954
     Act or the implementation of the above provisions

PROVIDED THAT (in the case of all the rights reserved in this Schedule) the
Landlord shall procure that as little inconvenience and damage as possible is
caused in the exercise of such rights and shall forthwith make good all damage
caused

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                                       28

                                 SECOND SCHEDULE

                                   RENT REVIEW

                      PART I - RENT REVIEW UNDER THIS LEASE

1    DEFINITIONS

     In this Schedule the following expressions shall have the following
     meanings:

1.1  "ACTUAL BUILDING RENT" means in respect of any Review Date an amount
     representing whichever shall be the greater of either:

     (i)  the annual rent or

     (ii) the aggregate annual rents

     which (in either case) (after the expiry of such rent free or concessionary
     rent period as would in the then state of the market normally be allowed to
     a willing tenant of the Premises or the relevant part thereof (not however
     exceeding the period which it would be reasonable to expect him to need to
     fit out and equip the Premises to meet his particular requirements)) could
     on that Review Date reasonably be expected to be obtained in the open
     market for the Premises if they were then vacant on the grant of a lease of
     the whole or separate leases of (i) the Office Building and (ii) the
     Production Building by a willing landlord to a willing tenant or tenants
     for a term of fifteen years commencing on the relevant Review Date and
     having regard to the terms of any licences granted by the Landlord at the
     request of the Tenant and any waiver or variation by the parties of any of
     the covenants and conditions contained in this lease and otherwise making
     the Assumptions but disregarding the Disregarded Matters

1.2  "APPLICABLE NOTIONAL OFFICE RENT" means (i) in respect of any Review Date
     except the first and second the Notional Office Rent in relation to
     whatever is the Selected Town in respect of that Review Date and (ii) in
     respect of the first and second Review Dates whichever is the highest at
     that Review Date of:

1.2.1 the Notional Office Rent in relation to Luton or

1.2.2 the Notional Office Rent in relation to Milton Keynes or

1.2.3 the Notional Office Rent in relation to Northampton or

1.2.4 the Notional Office Rent in relation to Wellingborough

1.3  "APPLICABLE NOTIONAL PRODUCTION RENT" means (i) in respect of any Review
     Date except the first and second the Notional Production Rent in relation
     to whatever is the Selected Town in respect of that Review Date and (ii) in
     respect of the first and second Review Dates whichever is the highest at
     that Review Date of:

1.3.1 the Notional Production Rent in relation to Luton or

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                                       29

1.3.2 the Notional Production Rent in relation to Milton Keynes or

1.3.3 the Notional Production Rent in relation to Northampton or

1.3.4 the Notional Production Rent in relation to Wellingborough

1.4  "ASSUMPTIONS" means the following assumptions (if not facts) at the
     relevant Review Date:

1.4.1 That the Premises or the Qualifying Premises (as the case may be) are
     fitted out for immediate occupation and use

1.4.2 That in the case of the Office Building the Net Internal Area excludes the
     area shown hatched black on the "Net Internal Area" drawings attached
     hereto and that in the case of the Office Building or the Qualifying Office
     Premises they have the benefit of good natural lighting throughout and that
     it or they are fitted equipped and finished in the manner and to the
     standards and using materials of the quality specified in the Notional
     Office Building Specification attached to this lease

1.4.3 That in the case of the Production Building the Gross Internal Area is 682
     square feet less than the actual Gross Internal Area and that in the case
     of the Production Building or the Qualifying Production Premises they have
     clear regular space with a clear height at ground floor level of 8 metres,
     eight loading doors (in the case of the Production Building) and one
     loading door for every 10,000 square feet of the Gross Internal Area of the
     building (in the case of the Qualifying Production Premises), and (in
     either case) the site of the building is such that the gross external
     ground floor area of the building is in the range 40%-45% of the gross site
     area and includes a service yard as appropriate to the size of the
     premises, and that it or they are fitted, equipped and finished in the
     manner and to the standards and using materials of the quality specified in
     the Notional Production Building Specification attached to this lease

1.4.4 That the premises being let are suitable for use, as to the Office
     Building or the Qualifying Office Premises within Class B1 (a) and/or Class
     B1 (b) (with ancillary uses), and as to the Production Building or the
     Qualifying Production Premises within Classes Bl(c) and/or B8 (with
     ancillary uses), or (in either case) any other use permitted by any licence
     given by the Landlord at the request of the Tenant and have planning
     permission for such uses

1.4.5 That no work has been carried out to the Premises by the Tenant any
     undertenant or their respective predecessors in title during the Term or
     during any period of occupation prior thereto which has diminished the
     rental value of the Premises

1.4.6 That if the Premises or any part or parts thereof have been destroyed or
     damaged they have been fully rebuilt and reinstated

1.4.7 That the Premises or the Qualifying Premises (as the case may be) are in a
     good state of repair and decorative condition

1.4.8 That all the covenants contained in this lease have been fully performed
     and observed

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                                       30

1.4.9 That the Qualifying Premises have and will have throughout the term
     required to be calculated for the purposes of such lease the benefit of all
     rights easements quasi-easements permissions approvals services facilities
     and amenities (whether the same be required from the Landlord or from any
     other person or authority) which are necessary or appropriate so as to
     enable the willing tenant properly and beneficially to occupy use and enjoy
     the Qualifying Premises

1.4.10 That otherwise such lease shall be upon the same terms and conditions as
     those of this lease (except as to the initial amount of the Rent first
     hereby reserved and except also that (i) the rent reviews shall be at
     five-yearly intervals from the commencement of the hypothetical term and
     (ii) the Second Schedule to such lease (containing the provisions for the
     review of rent) shall be in the form set out in Part II of this Schedule in
     substitution for this Schedule (with the appropriate alternative wording in
     the case of paragraph 1.1.2))

1.5  "CLASS B1(A)", "CLASS B1(B)", "CLASS B1(C)" AND "CLASS B8" mean
     respectively those Classes in the Schedule to the Town and Country Planning
     (Use Classes) Order 1987

1.6  "DISREGARDED MATTERS"' means:

1.6.1 Any effect on rent of the fact that the Tenant any permitted undertenant
     or their respective predecessors in title have been in occupation of the
     Premises or any part thereof

1.6.2 Any goodwill attached to the Premises by reason of the business then
     carried on at the Premises by the Tenant or any permitted undertenant

1.6.3 Any value attributable to the existence of any tenant's trade fixtures and
     fittings or any other equipment or property of the Tenant in the Premises

1.6.4 Any increase in rental value of the Premises attributable to the existence
     at the relevant Review Date of any improvement to the Premises or any part
     thereof carried out during the Term or during any period of occupation
     prior thereto arising out of an agreement to grant this lease by the Tenant
     or any permitted undertenant or their respective predecessors in title
     otherwise than in pursuance of an obligation to the Landlord or its
     predecessors in title

1.6.5 Any effect on rent of any obligation of the Tenant arising under this
     lease or any deed licence consent or other instrument granted by the
     Landlord at the request of the Tenant to reinstate the Premises to the same
     condition or design as they were before the carrying out of any works to
     the Premises or to comply with the provisions of Clause 5.16.2

1.6.6 In relation to the Qualifying Premises such of the matters referred to in
     this paragraph 1.6 as would be expected to be disregarded had the Tenant
     been in occupation of the Qualifying Premises

1.7  "GROSS INTERNAL AREA" AND "NET INTERNAL AREA" mean respectively a floor
     area expressed in square feet measured in accordance with the corresponding
     definition contained in the Fourth Edition of the Code of Measuring
     Practice published in

<PAGE>

                                       31

     November 1993 by Surveyors Holdings Limited on behalf of the Royal
     Institution of Chartered Surveyors and the Incorporated Society of Valuers
     and Auctioneers ("the Current Code") or such later edition of that Code as
     may be current at the Relevant Review Date or in accordance with such other
     normally accepted method of measuring premises of the relevant type as may
     at the Relevant Review Date have superseded the Current Code (any such
     later edition or other method being referred to in this Schedule as a "New
     Code")

1.8  "NOTIONAL LEASE" means a lease of the relevant Qualifying Premises on the
     following terms:

1.8.1 The permitted user shall be Class B1(a) and/or Class B1(b) in the case of
     Qualifying Office Premises and Class B1(c) and/or Class B8 in the case of
     Qualifying Production Premises (in each case with ancillary uses)

1.8.2 The lease shall permit the Tenant to underlet such parts of the relevant
     Qualifying Premises (as well as the whole) as shall correspond more or less
     with the size of parts of the Premises as may be underlet under the terms
     of this lease and to create such number of underlettings as shall be
     appropriate to the size of the premises (having regard to the number of
     underlettings permitted under this lease)

1.8.3 Otherwise such lease shall be upon the same terms and conditions (mutatis
     mutandis) as those of this lease (except as to the initial amount of the
     Rent first hereby reserved and except also that (i) the rent reviews shall
     be at five-yearly intervals from the commencement of the hypothetical term
     and (ii) the Second Schedule to such lease (containing the provisions for
     the review of rent) shall be in the form set out in Part II of this
     Schedule in substitution for this Schedule (with the appropriate
     alternative wording in the case of paragraph 1.1.2))

1.9  "NOTIONAL OFFICE RENT" means in relation to any Specified Town the annual
     rent per square foot of Net Internal Area which (after the expiry of such
     rent free or concessionary rent period as would in the then state of the
     market normally be allowed to a willing tenant of Qualifying Office
     Premises (not however exceeding the period which it would be reasonable to
     expect him to need to fit out and equip those premises to meet his
     particular requirements)) could on that Review Date reasonably be expected
     to be obtained in the open market for Qualifying Office Premises in that
     Specified Town if they were then vacant on the grant of a Notional Lease of
     them by a willing landlord to a willing tenant for a term of fifteen years
     commencing on the relevant Review Date and otherwise making the Assumptions
     applicable to Qualifying Office Premises but disregarding the Disregarded
     Matters applicable to Qualifying Office Premises

1.10 "NOTIONAL PRODUCTION RENT" means in relation to any Specified Town the
     annual rent per square foot of Gross Internal Area which (after the expiry
     of such rent free or concessionary rent period as would in the then state
     of the market normally be allowed to a willing tenant of Qualifying
     Production Premises (not however exceeding the period which it would be
     reasonable to expect him to need to fit out and equip those premises to
     meet his particular requirements)) could on that Review Date reasonably be
     expected to be obtained in the open market for Qualifying Production
     Premises in that Specified Town if they were then vacant on the grant of a
     Notional Lease of them by a willing landlord to a willing tenant for a term
     of fifteen years commencing on the relevant

<PAGE>

                                       32

     Review Date and otherwise making the Assumptions applicable to Qualifying
     Production Premises but disregarding the Disregarded Matters applicable to
     Qualifying Production Premises

1.11 "NOTIONAL RENT" means the aggregate of:

1.11.1 the Applicable Notional Office Rent multiplied by fifty-three thousand
     seven hundred and eighty-six (53,786) and

1.11.2 the Applicable Notional Production Rent multiplied by eighty-six thousand
     and twenty-one (86,021)

     PROVIDED THAT it is agreed that the multipliers referred to in paragraphs
     1.11.1 and 1.11.2 represent respectively the Net Internal Area of the
     Office Building and the Gross Internal Area (less 682 square feet) of the
     Production Building as measured in accordance with the Current Code and
     that if at the Relevant Review Date the Current Code shall have been
     superseded by a New Code under which the basis of measurement of buildings
     of the same type as the relevant building is different from the basis of
     measurement of such buildings under the Current Code then the multiplier
     for each building shall instead be the Net Internal Area (in the case of
     the Office Building) or the Gross Internal Area less an amount equivalent
     to 682 square feet under the Current Code (in the case of the Production
     Building) of the relevant building measured in accordance with the New Code

     PROVIDED FURTHER that if at the Relevant Review Date the expression "Net
     Internal Area" and/or "Gross Internal Area" shall have been replaced by a
     different expression then that different expression shall be substituted
     for "Net Internal Area" and/or "Gross Internal Area" (as appropriate) in
     this paragraph 1.11 and in paragraphs 1.9 and 1.10 above

1.12 "PRESIDENT" means the President for the time being of the Royal Institution
     of Chartered Surveyors and includes the duly appointed deputy of the
     President or any person authorised by the President to make appointments on
     his behalf

1.13 "QUALIFYING PREMISES" means Qualifying Office Premises or Qualifying
     Production Premises (as appropriate)

1.14 "QUALIFYING OFFICE PREMISES" means office premises having a Net Internal
     Area of fifty thousand (50,000) square feet (or if it proves impossible to
     find comparable evidence in order to value a building of that size then
     thirty thousand (30,000) square feet) which is located in what is (at the
     time of the relevant Review Date) a good out of town business park
     location:

1.14.1 In Wellingborough or Northampton or Luton or

1.14.2 In Milton Keynes outside the central business district shown edged red on
     the attached plan showing Central Milton Keynes

1.15 "QUALIFYING PRODUCTION PREMISES" means production and/or warehouse premises
     having a Gross Internal Area of eighty thousand (80,000) square feet:

<PAGE>

                                       33

1.15.1 In the case of Wellingborough Northampton or Luton in a location outside
     the relevant town centre

1.15.2 In the case of Milton Keynes in a location outside the central business
     district shown edged red on the attached plan showing Central Milton Keynes

1.16 "REVISED RENT" means in respect of any Review Date the greatest of:

1.16.1 The Actual Building Rent in respect of that Review Date and

1.16.2 The Notional Rent in respect of that Review Date and

1.16.3 The Rent payable under this lease immediately before the relevant Review
     Date (or which would have been payable but for the operation of the cesser
     of rent provision (if applicable))

1.17 "THE SELECTED TOWN" means in respect of any Review Date other than the
     first and second Review Dates (in relation to which this expression is of
     no relevance) the Specified Town selected by the Landlord for the purposes
     of the rent review at that Review Date and it is agreed that in respect of
     any such Review Date:

1.17.1 Only one town may be selected (so that the same town shall be the
     Selected Town in relation to both the Applicable Notional Office Rent and
     the Applicable Notional Production Rent)

1.17.2 The town selected need not be (but may be) the town which was selected in
     respect of the previous Review Date.

1.17.3 The selection may be made after the Notional Office Rent and Notional
     Production Rent in relation to all the Specified Towns has been ascertained

1.18 "SPECIFIED TOWNS" are Luton, Milton Keynes, Northampton and Wellingborough
     and a "Specified Town" means any of them

1.19 "SURVEYOR" means an independent chartered surveyor of not less than ten
     (10) years standing who is experienced in the valuation and leasing of
     commercial property appointed from time to time to determine either or both
     of the Actual Building Rent and the Notional Rent pursuant to the
     provisions of this Schedule

2    UPWARDS ONLY RENT REVIEW

2.1  The Rent first reserved by this lease shall be reviewed at each Review Date
     in accordance with the provisions of this Schedule and from and including
     each Review Date the Rent shall subject to paragraph 2.2 below be the
     Revised Rent in respect of that Review Date as agreed or determined
     pursuant to the provisions of this Schedule

2.2  Following the first Review Date the Rent shall not be less than the Initial
     Rent multiplied by 1.2167 (one-decimal point-two-one-six-seven) and
     following the second Review Date the Rent shall not be less than the
     Initial Rent multiplied by 1.4802 (one decimal point-four-eight-nought-two)

<PAGE>

                                       34

3    AGREEMENT OR DETERMINATION OF THE REVIEWED RENT

     The Actual Building Rent and the Notional Rent at any Review Date may be
     agreed in writing at any time between the Landlord and the Tenant but if
     for any reason (whether through failure or omission to agree or negotiate
     or to initiate any negotiation) the Landlord and the Tenant have not so
     agreed either or both of the Actual Building Rent and the Notional Rent
     then either the Landlord or the Tenant may (whether before or after the
     relevant Review Date) by notice in writing to the other party require
     whichever of the Actual Building Rent and the Notional Rent has not then
     been so agreed to be determined by the Surveyor

4    APPOINTMENT OF SURVEYOR

     In default of agreement between the Landlord and the Tenant on the
     appointment jointly of the Surveyor the Surveyor shall be appointed by the
     President on the written application of either the Landlord or the Tenant
     who shall be at liberty to make such application not earlier than three (3)
     months before or at any such time after the relevant Review Date

5    FUNCTIONS OF THE SURVEYOR

     The Surveyor shall:

5.1  act as an arbitrator in accordance with the Arbitration Acts 1950 to 1979

5.2  within sixty (60) days of his appointment or within such extended period as
     the Landlord and the Tenant shall jointly agree in writing give to each of
     them written notice of the amount of either or both of the Actual Building
     Rent and the Notional Rent (as the case may be) as determined by him

6    COSTS OF REFERENCE TO SURVEYOR

     The costs of any reference to the Surveyor shall be in the award of the
     Surveyor and whatever the award of the Surveyor his costs may be paid in
     full by either party in order to secure the release of his award or
     determination and in that event the other party shall reimburse to the
     paying party the share of those costs payable by him

7    INTERIM PAYMENTS PENDING DETERMINATION

7.1  In the event that by any Review Date the amount of the Revised Rent has not
     been agreed or determined as aforesaid (the date of agreement or
     determination being herein called "the Determination Date") then in respect
     of the period of time (herein called "the Interim Period") beginning with
     that Review Date and ending on the day before the quarter day following the
     Determination Date the Tenant shall pay to the Landlord rent at the yearly
     rate payable immediately before the relevant Review Date and on the
     Determination Date the Tenant shall pay to the Landlord on demand the
     amount by which the Revised Rent exceeds the Rent actually paid during the
     Interim Period together with interest thereon at 3% below the Interest Rate
     from the relevant Review Date to the date of actual payment

<PAGE>

                                       35

7.2  In the case of the rent reviews at the first and second Review Dates, where
     paragraph 7.1. above applies the payment in respect of the Interim Period
     shall be at the rate of the minimum Rent payable after the relevant Review
     Date pursuant to paragraph 2.2

8    MEMORANDA OF REVISED RENT

     As soon as the amount of any Revised Rent has been agreed or determined
     memoranda thereof or where applicable of the Rent payable pursuant to
     paragraph 2.2 above shall be prepared by the Landlord or its solicitors and
     thereupon shall be signed by or on behalf of the Landlord and the Tenant
     and annexed to this lease and the counterpart thereof and the parties shall
     bear their own costs in respect thereof

9    TIME NOT OF THE ESSENCE

For the purpose of this Schedule time shall not be of the essence

<PAGE>

                                       36

                 PART II - NOTIONAL LEASE RENT REVIEW PROVISIONS
              [REFERRED TO IN PARAGRAPHS 1.4.10 AND 1.8 OF PART I]

1    DEFINITIONS

     In this Schedule the following expressions shall have the following
     meanings:

1.1  "ASSUMPTIONS" means the following assumptions (if not facts) at the
     relevant Review Date:

1.1.1 That the Premises are fitted out for immediate occupation and use

1.1.2 [IN CASE OF ASSUMED LETTING OF PREMISES AS A WHOLE FOR THE PURPOSES OF
     DETERMINING THE ACTUAL BUILDING RENT]

     That the Premises are suitable for use as to the Office Building within
     Class B1(a) and/or Class B1(b) (with ancillary uses) and as to the
     Production Building within Classes B1 (c) and/or B8 (with ancillary uses)
     or (in either case) any other use permitted by any licence given by the
     Landlord at the request of the Tenant and have planning permission for such
     uses

     [IN CASE OF ASSUMED LETTING OF THE OFFICE BUILDING OR QUALIFYING OFFICE
     PREMISES]

     That the premises being let are suitable for use within Class B1 (a) and/or
     Class B1(b) (with ancillary uses) or any other use permitted by any licence
     given by the Landlord at the request of the Tenant and have planning
     permission for such uses

     [IN CASE OF ASSUMED LETTING OF THE PRODUCTION BUILDING OR QUALIFYING
     PRODUCTION PREMISES]

     That the premises being let are suitable for use within Class B1(c) and/or
     Class B8 (with ancillary uses) or any other use permitted by any licence
     given by the Landlord at the request of the Tenant and have planning
     permission for such uses

1.1.3 That no work has been carried out to the Premises by the Tenant any
     undertenant or their respective predecessors in title during the Term or
     during any period of occupation prior thereto which has diminished the
     rental value of the Premises

1.1.4 That if the Premises or any part or parts thereof have been destroyed or
     damaged they have been fully rebuilt and reinstated

1.1.5 That the Premises are in a good state of repair and decorative condition

1.1.6 That all the covenants contained in this lease have been fully performed
     and observed

1.1.7 That otherwise such lease shall be upon the same terms and conditions as
     those of this lease (except as to the initial amount of the Rent first
     hereby reserved and except also that the rent reviews shall be at
     five-yearly intervals from the commencement of the hypothetical term)

1.2  "CLASS B1(A)", "CLASS B1(B)", "CLASS B1(C)" AND "CLASS B8" mean
     respectively those Classes in the Schedule to the Town and Country Planning
     (Use Classes) Order 1987

<PAGE>

                                       37

1.3  "DISREGARDED MATTERS" means:

1.3.1 Any effect on rent of the fact that the Tenant, any permitted undertenant
     or their respective predecessors in title have been in occupation of the
     Premises or any part thereof

1.3.2 Any goodwill attached to the Premises by reason of the business then
     carried on at the Premises by the Tenant or any permitted undertenant

1.3.3 Any value attributable to the existence of any tenant's trade fixtures and
     fittings or any other equipment or property of the Tenant in the Premises

1.3.4 Any increase in rental value of the Premises attributable to the existence
     at the relevant Review Date of any improvement to the Premises or any part
     thereof carried out during the Term or during any period of occupation
     prior thereto arising out of an agreement to grant this lease by the Tenant
     or any permitted undertenant or their respective predecessors in title
     otherwise than in pursuance of an obligation to the Landlord or its
     predecessors in title

1.3.5 Any effect on rent of any obligation of the Tenant arising under this
     lease or any deed licence consent or other instrument granted by the
     Landlord at the request of the Tenant to reinstate the Premises to the same
     condition or design as they were before the carrying out of any works to
     the Premises

1.4  "MARKET RENT" means in respect of any Review Date an amount representing
     the annual rent which (after the expiry of such rent free or concessionary
     rent period as would in the then state of the market normally be allowed to
     a willing tenant of the Premises (not however exceeding the period which it
     would be reasonable to expect him to need to fit out and equip the Premises
     to meet his particular requirements)) could on that Review Date reasonably
     be expected to be obtained in the open market for the Premises if they were
     then vacant on the grant of a lease of them by a willing landlord to a
     willing tenant for a term of fifteen years commencing on the relevant
     Review Date and having regard to the terms of any licences granted by the
     Landlord at the request of the Tenant and any waiver or variation by the
     parties of any of the covenants and conditions contained in this lease and
     otherwise making the Assumptions but disregarding the Disregarded Matters

1.5  "PRESIDENT" means the President for the time being of the Royal Institution
     of Chartered Surveyors and includes the duly appointed deputy of the
     President or any person authorised by the President to make appointments on
     his behalf

1.6  "REVISED RENT" means in respect of any Review Date the greater of:

1.6.1 The Market Rent in respect of that Review Date and

1.6.2 The Rent payable under this lease immediately before the relevant Review
     Date (or which would have been payable but for the operation of the cesser
     of rent provision (if applicable))

<PAGE>

                                       38

1.7  "SURVEYOR" means an independent chartered surveyor of not less than ten
     (10) years standing who is experienced in the valuation and leasing of
     commercial property appointed from time to time to determine the Market
     Rent pursuant to the provisions of this Schedule

2    UPWARDS ONLY RENT REVIEW

     The Rent first reserved by this lease shall be reviewed at each Review Date
     in accordance with the provisions of this Schedule and from and including
     each Review Date the Rent shall be the Revised Rent in respect of that
     Review Date as agreed or determined pursuant to the provisions of this
     Schedule

3    AGREEMENT OR DETERMINATION OF THE REVIEWED RENT

     The Market Rent at any Review Date may be agreed in writing at any time
     between the Landlord and the Tenant but if for any reason (whether through
     failure or omission to agree or negotiate or to initiate any negotiation)
     the Landlord and the Tenant have not so agreed the Market Rent then either
     the Landlord or the Tenant may (whether before or after the relevant Review
     Date) by notice in writing to the other party require the Market Rent to be
     determined by the Surveyor

4    APPOINTMENT OF SURVEYOR

     In default of agreement between the Landlord and the Tenant on the
     appointment jointly of the Surveyor the Surveyor shall be appointed by the
     President on the written application of either the Landlord or the Tenant
     who shall be at liberty to make such application not earlier than three (3)
     months before or at any such time after the relevant Review Date

5    FUNCTIONS OF THE SURVEYOR

     The Surveyor shall:

5.1  act as an arbitrator in accordance with the Arbitration Acts 1950 to 1979

5.2  within sixty (60) days of his appointment or within such extended period as
     the Landlord and the Tenant shall jointly agree in writing give to each of
     them written notice of the amount of the Market Rent as determined by him

6    COSTS OF REFERENCE TO SURVEYOR

     The costs of any reference to the Surveyor shall be in the award of the
     Surveyor and whatever the award of the Surveyor his costs may be paid in
     full by either party in order to secure the release of his award or
     determination and in that event the other party shall reimburse to the
     paying party the share of those costs payable by him

7    INTERIM PAYMENTS PENDING DETERMINATION

     In the event that by any Review Date the amount of the Revised Rent has not
     been agreed or determined as aforesaid (the date of agreement or
     determination being herein

<PAGE>

                                       39

     called "the Determination Date") then in respect of the period of time
     (herein called "the Interim Period") beginning with that Review Date and
     ending on the day before the quarter day following the Determination Date
     the Tenant shall pay to the Landlord rent at the yearly rate payable
     immediately before the relevant Review Date and on the Determination Date
     the Tenant shall pay to the Landlord on demand the amount by which the
     Revised Rent exceeds the Rent actually paid during the Interim Period
     together with interest thereon at 3% below the Interest Rate from the
     relevant Review Date to the date of actual payment

8    MEMORANDA OF REVISED RENT

     As soon as the amount of any Revised Rent has been agreed or determined
     memoranda thereof shall be prepared by the Landlord or its solicitors and
     thereupon shall be signed by or on behalf of the Landlord and the Tenant
     and annexed to this lease and the counterpart thereof and the parties shall
     bear their own costs in respect thereof

9    TIME NOT OF THE ESSENCE

     For the purpose of this Schedule time shall not be of the essence

<PAGE>

                                       40

                                 THIRD SCHEDULE

                               THE USER COVENANTS

1    USER

1.1  Not to use the Premises other than for the Permitted User

1.2  Not to discharge into any of the Pipes serving the Premises or any other
     property any oil grease or other deleterious matter or any substance which
     might be or become a source of danger or injury to the drainage system of
     the Premises

1.3  Not to install or use in or upon the Premises any machinery or apparatus
     which causes noise or vibration which can be excessively heard or felt in
     nearby premises or outside the Premises or which may cause damage

1.4  Not to play or use any musical instrument loudspeaker tape recorder
     gramophone radio or other equipment or apparatus that produces sound in the
     Premises so as to be heard in nearby premises or outside the Premises

1.5  Not to display any flashing lights in the Premises that can be seen from
     outside the Premises

2    ALTERATIONS

2.1  Not to make any structural alteration or addition to the Premises without
     the prior written consent of the Landlord (such consent not to be
     unreasonably withheld or delayed)

2.2  To make connection with any Pipes serving the Premises only if consent to
     make such connection has previously been obtained from the competent
     statutory authority or undertaker (if applicable)

3    SIGNS AND ADVERTISEMENTS

     Not to place or display on the exterior of the Premises any notice sign
     placard or advertisement other than:

3.1  directional signs or

3.2  suitable signs of a size and kind first approved in writing by the Landlord
     (such approval not to be unreasonably withheld or delayed)

4    OPEN AREAS

4.1  To keep any landscaped areas within the Premises well maintained in
     accordance with the rules of good husbandry

4.2  Not to allow any material manufactured or part manufactured goods tools
     machinery unroadworthy vehicles pallets packaging waste or rubbish to be
     stored in or left on any open areas within the Premises (but for the
     avoidance of doubt this does not include

<PAGE>

                                       41

     any areas within the Premises which are screened for such purposes or
     within any service yard/area with a perimeter wall or close-boarded fence
     of no less than 2 metres in height

4.3  To keep all open areas within the Premises clean and tidy

5    CEILING AND FLOOR LOADING

     Not to bring or permit to remain upon the Premises any safes machinery
     goods or other articles which shall or may strain or damage the Premises or
     any part of them

6    ESTATE ROADS

6.1  Not to permit any vehicles belonging to the Tenant or any persons calling
     on the Premises expressly or by implication with the authority of the
     Tenant to stand on the Estate Roads or the pavements and to use its
     reasonable endeavours to ensure that such persons calling on the Premises
     do not permit any vehicle to stand on any such road or pavement

6.2  Pending adoption as public highway maintainable at public expense, not to
     bring for the use upon the Estate Roads any vehicle or machine not suitable
     for use upon a public highway or which, although suitable, are overloaded
     or used in an improper manner and to indemnify the Landlord and Superior
     Landlord in respect of any damage caused to the surface of the Estate Roads
     as the result of a breach of this covenant

<PAGE>

                                       42

                                 FOURTH SCHEDULE

                              GUARANTOR'S COVENANTS

The Guarantor covenants with the Landlord and without the need for any express
assignment with all its successors in title that:

1    TO PAY OBSERVE AND PERFORM

     During the Term the Assignee (which expression in this and the following
     covenants shall include its successors in title) shall punctually pay the
     rents and observe and perform the covenants and other terms of the lease
     and if at any time during the Term the Assignee shall make any default in
     payment of the rents or in observing or performing any of the covenants or
     other terms of the lease the Guarantor will pay the rents and observe or
     perform the covenants or terms in respect of which the Assignee shall be in
     default and make good to the Landlord on demand and indemnify the Landlord
     against all losses damages costs and expenses arising or incurred by the
     Landlord as a result of such non-payment non-performance or non-observance
     (including but without limitation any costs and expenses properly incurred
     by the Landlord in obtaining payment of any monies due from the Guarantor
     pursuant to this covenant) notwithstanding:

1.1  any time or indulgence granted by the Landlord to the Assignee or any
     neglect or forbearance of the Landlord in enforcing the payment of the
     rents or the observance or performance of the covenants or other terms of
     the lease or any refusal by the Landlord to accept rents tendered by or on
     behalf of the Assignee at a time when the Landlord was entitled (or would
     after the service of a notice under the Law of Property Act 1925 Section
     146 have been entitled) to re-enter the Premises

1.2  that the terms of the lease may have been varied by agreement between the
     parties

1.3  that the Assignee shall have surrendered part of the Premises in which
     event the liability of the Guarantor under the lease shall continue in
     respect of the part of the Premises not so surrendered after making any
     necessary apportionments under the Law of Property Act 1925 Section 140 and

1.4  any other act or thing (other than a release by deed) by which but for this
     provision the Guarantor would have been released

2    TO TAKE LEASE FOLLOWING DISCLAIMER

     If at any time during the Term the Assignee (being an individual) shall
     become bankrupt or (being a company) shall enter into liquidation and the
     trustee in bankruptcy or liquidator shall disclaim the lease or if (being a
     company) the Assignee shall be struck off the register of companies or
     shall be dissolved the Guarantor shall if the Landlord shall by notice
     within 6 months after such disclaimer or other event so require take from
     the Landlord a lease of the Premises for the residue of the Contractual
     Term which would have remained had there been no disclaimer or other event
     at the rents payable under the lease immediately before such disclaimer or
     other event and subject to the same covenants and terms as in the lease
     (except that the Guarantor shall not be

<PAGE>

                                       43

     required to procure that any other person is made a party to that lease as
     guarantor) such new lease to take effect from the date of such disclaimer
     and in such case the Guarantor shall pay the reasonable and proper costs of
     such new lease and execute and deliver to the Landlord a counterpart of it

3    TO MAKE PAYMENTS FOLLOWING DISCLAIMER

     If the lease shall be disclaimed and for any reason the Landlord does not
     require the Guarantor to accept a new lease of the Premises in accordance
     with paragraph 2 of this Schedule the Guarantor shall pay to the Landlord
     on demand an amount equal to the difference between any money received by
     the Landlord for the use or occupation of the Premises and the rents
     payable or which would (but for such disclaimer or other event) have been
     payable under the lease for the period commencing with the date of such
     disclaimer and ending on whichever is the earlier of the following dates:

3.1  the date 6 months after such disclaimer and

3.2  the date (if any) upon which the Premises are relet

<PAGE>

                                                                   Exhibit 10.40

THE COMMON SEAL OF UNILEVER     )
UK CENTRAL RESOURCES LIMITED    )
was affixed in the presence of: )   /s/ ILLEGIBLE
                                    --------------------------------------------
Director

Secretary                           /s/ ILLEGIBLE
                                    --------------------------------------------

EXECUTED AS A DEED by UNIPATH   )
LIMITED acting by:              )   /s/ Kevin Stearn
                                    --------------------------------------------
                                    Kevin Stearn, Managing Director

Director

Director/Secretary                  /s/ Rod Whitaker
                                    --------------------------------------------
                                    Rod Whitaker, Company Secretary

EXECUTED AS A DEED by           )
INVERNESS MEDICAL               )
INNOVATIONS INC acting by its   )
assistant secretary:            )

Assistant Secretary                 /s/ Jay McNamara
                                    --------------------------------------------
                                    Jay McNamara, Assistant Secretary

<PAGE>

                                       45

ANNEXURES: PLAN A

           PLAN B

           PLAN C

           A COPY OF THE SUPERIOR LEASE (INCLUDES A COPY OF THE HEADLEASE)<PAGE>

                                                                   EXHIBIT 10.41

                                 AMENDMENT NO. 4

                                       TO

                       INVERNESS MEDICAL INNOVATIONS, INC.

                      2001 STOCK OPTION AND INCENTIVE PLAN

     The Inverness Medical Innovations, Inc. 2001 Stock Option and Incentive
Plan (the "Plan") is hereby amended as follows, effective as of the date
approved by the Board as set forth below.

1. Section 2(a) is hereby deleted in its entirety and replaced with the
following:

     "Committee. The Plan shall be administered by either the Board or a
     committee of not less than two Independent Directors (in either case, the
     "Administrator"), as determined by the Board from time to time; provided
     that, for purposes of Awards to Directors or Section 16 officers of the
     Company, the Administrator shall be deemed to include only Directors who
     are Independent Directors and no director who is not an Independent
     Director shall be entitled to vote or take action in connection with any
     such proposed Award."

2. Section 2(b)(iv) is hereby deleted in its entirety and replaced with the
following:

     "to determine and modify from time to time the terms and conditions,
     including restrictions, not inconsistent with the terms of the Plan, of any
     Award, which terms and conditions may differ among individual Awards and
     grantees, and to approve the form of written instruments evidencing the
     Awards; provided that, other than by reason of death, disability,
     retirement or Change of Control, the Administrator shall not accelerate or
     waive any restriction period applicable to any outstanding Restricted Stock
     Award or any Deferred Stock Award beyond the minimum restriction periods
     set forth in Section 6(e) and Section 7(d), respectively, nor shall the
     Administrator accelerate or amend the aggregate period over which any
     Performance Share Award is measured to less than one (1) year;"

3. The first sentence of Section 5(a)(i) is hereby amended by deleting the
phrase "(other than options granted in lieu of cash compensation)."

4. Section 7(d) is hereby deleted in its entirety and replaced with the
following:

     "Restrictions. Deferred Stock Awards vesting upon the attainment of
     performance goals or objectives shall vest after a restriction period of
     not less than one (1) year. All other Deferred Stock Awards shall vest
     after a restriction period of not less than three (3) years.

<PAGE>

     A Deferred Stock Award may not be sold, assigned, transferred, pledged or
     otherwise encumbered or disposed of during the deferral period."

5. Section 8(a) is hereby amended by adding the following sentence to the end of
the current provision:

     "The aggregate number of shares of Stock issuable pursuant to this Section
     8 is limited to ten percent (10%) of the maximum number of shares of Stock
     reserved and available for issuance under the Plan pursuant to Section
     3(a), as amended."

6. Section 9(a) is hereby amended by deleting the last sentence of the current
provision and replacing it with the following sentence:

     "The Administrator in its sole discretion shall determine whether and to
     whom Performance Share Awards shall be made, the performance goals, the
     periods during which performance is to be measured (which in the aggregate
     shall not be less than one (1) year), and all other limitations and
     conditions."

7. Section 9(e) entitled "Acceleration, Waiver, Etc." is hereby deleted in its
entirety.

8. Section 13 is hereby amended by deleting the first sentence of the current
provision and replacing with the following sentence:

     "Subject to requirements of law or any stock exchange or other similar
     rules which would require a vote of the Company's shareholders, the Board
     may, at any time, amend or discontinue the Plan and the Administrator may,
     at any time, amend or cancel any outstanding Award for the purpose of
     satisfying changes in law or for any other lawful purpose, but no such
     action shall adversely affect rights under any outstanding Award without
     the holder's consent."

9. Section 16(a) is hereby amended by adding the following paragraph directly
after the last paragraph of the current provision:

     "No Award under the Plan shall be a nonqualified deferred compensation
     plan, as defined in Code Section 409A, unless such Award meets in form and
     in operation the requirements of Code Section 409A(a) (2), (3), and (4)."

10. Except as herein expressly amended, the provisions of the Plan shall remain
in full force and effect.

AS APPROVED BY THE BOARD OF DIRECTORS: November 7, 2006

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