Document:

<PAGE>   1

                                                                   EXHIBIT 10.21

               THESE WARRANTS WILL EXPIRE AND BECOME NULL AND VOID
            AT 4:00 P.M. (PACIFIC STANDARD TIME) ON OCTOBER 23, 2003

                                    WARRANTS
                          TO PURCHASE COMMON SHARES OF
                                 NETSTAFF, INC.

             THIS IS TO CERTIFY THAT RICHARD MALCONIAN (the "Holder") has the
right to purchase, upon and subject to the terms and conditions hereinafter
referred to, up to 50,000 fully paid and non-assessable shares of common stock
(the "Shares") in the capital of NETSTAFF, INC. (hereinafter called the
"Company") for a period of three years October 24, 2000, until 4:00 p.m.
(Pacific Standard Time) on October 23, 2003 (the "Expiry Date") at a price of
$0.50 per Share.

        1.      ONE WARRANT AND $0.50 ARE REQUIRED TO PURCHASE ONE SHARE. THIS
                CERTIFICATE REPRESENTS 50,000 WARRANTS.

        2.      These Warrants are issued subject to the Terms and Conditions
                attached to the Warrants issued by the Company (the "Terms and
                Conditions") and dated October 24, 2000, and the Warrant Holder
                may exercise the right to purchase Shares only in accordance
                with those Terms and Conditions.

        3.      A copy of the Terms and Conditions may be obtained from the
                offices of the Company in the City of San Francisco, California.

        4.      Nothing contained herein or in the Terms and Conditions will
                confer any right upon the Holder hereof or any other person to
                subscribe for or purchase any Shares at any time subsequent to
                the Expiry Date, and from and after such time, this Warrant and
                all rights hereunder will be void and of no value.

             IN WITNESS WHEREOF the Company has caused its common seal to be
affixed and this Warrant to be signed by the undersigned, this 24th day of
October, 2000.

NETSTAFF, INC.

Per: /s/PATRICK RYLEE
    -----------------------------------
     Authorized Signatory

PLEASE NOTE THAT ALL SHARE CERTIFICATES MUST BE LEGENDED AS FOLLOWS:

"THESE SECURITIES HAVE NOT BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE
COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN
EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE
"SECURITIES ACT"), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT
TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO
AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE
REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE WITH
APPLICABLE STATE SECURITIES LAWS."

<PAGE>   2

                              FORM OF SUBSCRIPTION

TO: NETSTAFF, INC.

The undersigned Holder of the within Warrants hereby subscribes for ____________
shares of common stock (the "Shares") of Netstaff, Inc. (the "Company) pursuant
to the within Warrants at $1.00 per Share on the terms specified in the said
Warrants.

The undersigned hereby directs that the Shares be registered as follows:

<TABLE>
<CAPTION>
NAME(S) IN FULL              ADDRESS(ES)               NUMBER OF SHARES
---------------              -----------               ----------------
<S>                          <C>                       <C>

-----------------------      -------------------       -----------------------

-----------------------      -------------------       -----------------------

-----------------------      -------------------       -----------------------

                             TOTAL:
                                                       -----------------------
</TABLE>

(Please print full name in which share certificates are to be issued, stating
whether Mr., Mrs. or Miss is applicable).

DATED this ________ day of __________________, 20___.

In the presence of:

---------------------------------             ----------------------------------
Signature of Witness                          Signature of Warrant Holder

Please  print below your name and address in full.

Name
     -----------------------------------

Address
       -----------------------------------

------------------------------------------

<PAGE>   3

          TERMS AND CONDITIONS DATED OCTOBER 24, 2000, ATTACHED TO THE
             WARRANTS ISSUED BY NETSTAFF, INC. TO RICHARD MALCONIAN

ARTICLE 1 - INTERPRETATION

SECTION 1.1 - DEFINITIONS

In these Terms and Conditions, unless there is something in the subject matter
or context inconsistent therewith:

        (a)     "Company" means NETSTAFF, INC., until a successor corporation
                will have become such as a result of consolidation, amalgamation
                or merger with or into any other corporation or corporations, or
                as a result of the conveyance or transfer of all or
                substantially all of the properties and estates of the Company
                as an entirety to any other corporation, and thereafter
                "Company" will mean such successor corporation;

        (b)     "Company's Auditors" means an independent firm of accountants
                duly appointed as auditors of the Company;

        (c)     "Director" means a director of the Company for the time being,
                and reference, without more, to action by the directors means
                action by the directors of the Company as a Board, or whenever
                duly empowered, action by an executive committee of the Board;

        (d)     "herein," "hereby" and similar expressions refer to these Terms
                and Conditions as the same may be amended or modified from time
                to time; and the expression Article and Section, followed by a
                number refer to the specified Article or Section of these Terms
                and Conditions;

        (e)     "person" means an individual, corporation, partnership, trustee
                or any unincorporated organization and words importing persons
                have a similar meaning;

        (f)     "shares" means the common shares in the capital of the Company
                as constituted at the date hereof and any shares resulting from
                any subdivision or consolidation of the shares;

        (g)     "Warrant Holders" or "Holders" means the holders of the
                Warrants; and

        (h)     "Warrants" means the warrants of the Company issued and
                presently authorized, as set out in Section 2.01 hereof and for
                the time being outstanding, to RICHARD MALCONIAN.

<PAGE>   4

SECTION 1.2 - GENDER

Words importing the singular number include the plural and vice versa and words
importing the masculine gender include the feminine and neuter genders.

SECTION 1.3 - INTERPRETATION NOT AFFECTED BY HEADINGS

The division of these Terms and Conditions into Articles and Sections, and the
insertion of headings, are for convenience of reference only and will not affect
the construction or interpretation thereof.

SECTION 1.4 - APPLICABLE LAW

The Warrants will be construed in accordance with the laws of the State of
California applicable thereto and will be treated in all respects as California
contracts.

ARTICLE 2 - ISSUE OF WARRANTS

SECTION 2.1 - ISSUE OF WARRANTS

Warrants entitling the Holders thereof to purchase up to an aggregate of 50,000
shares have been authorized and are herewith issued by the Company. This Warrant
certificate represents 50,000 Warrants.

SECTION 2.2 - ADDITIONAL WARRANTS

The Company may, at any time, and from time to time, issue additional warrants
or grant options or similar rights to purchase shares of its capital stock.

SECTION 2.3 - WARRANTS TO RANK PARI-PASSU

These Warrants and additional warrants, options or similar rights to purchase
shares from time to time issued or granted by the Company, will rank pari-passu,
whatever may be the actual dates of issue or grant thereof, or of the dates of
the certificates by which they are evidenced.

SECTION 2.4 - ISSUE IN SUBSTITUTION FOR LOST WARRANTS

(1)     In case a Warrant certificate becomes mutilated, lost, destroyed or
        stolen, the Company, at its discretion, may issue and deliver a new
        Warrant certificate of like date and tenor as the one mutilated, lost,
        destroyed or stolen, in exchange for and in place of and upon
        cancellation of such mutilated Warrant certificate, or in lieu of, and
        in substitution for such lost, destroyed or stolen Warrant certificate
        and the substituted Warrant certificate will be entitled to the benefit
        hereof and rank equally in accordance with its terms with all other
        Warrants issued or to be issued by the Company.

(2)     The applicant for the issue of a new Warrant certificate pursuant hereto
        will bear the cost of the issue thereof and in case of loss, destruction
        or theft furnish to the Company such evidence of ownership and of loss,
        destruction, or theft of the Warrant certificate so lost, destroyed or
        stolen as will be satisfactory to the Company in its discretion and such
        applicant may also be required to furnish indemnity in amount and form

<PAGE>   5

        satisfactory to the Company in its discretion, and will pay the
        reasonable charges of the Company in connection therewith.

SECTION 2.5 - WARRANT HOLDER NOT A SHAREHOLDER

The holding of a Warrant will not constitute the holder thereof a shareholder of
the Company, nor entitle him to any right or interest in respect thereof except
as in the Warrant expressly provided.

ARTICLE 3 - NOTICE

SECTION 3.1 - NOTICE TO WARRANT HOLDERS

Any notice to be given to the Holders shall be given in writing and will be
given by personal delivery, telecopied or sent by prepaid, registered post,
addressed to the Holders at the address of the Holders appearing on the Holder's
Warrant certificate or to such other address as the Holders may advise the
Company by notice in writing, or by electronic means of communication.

The date of receipt of such notice shall be the date of delivery thereof if
delivered or telecopied, or, if given by registered mail, shall be deemed to be
the fourth business day after the same shall have been so mailed, except in the
case of interruption of postal services for any reason whatever, in which case,
the date of receipt shall be the date on which the notice, demand or other
communication is actually received by the addressee.

SECTION 3.2 - NOTICE TO THE COMPANY

Any notice to be given to the Company shall be given in writing and will be
given by personal delivery, telecopied or sent by prepaid, registered post,
addressed to the Company, at its business office, or delivered to the Company,
at its business office or to such other address as the Company may advise the
Holders by notice in writing, or by electronic means of communication.

The date of receipt of such notice shall be the date of delivery thereof if
delivered or telecopied, or, if given by registered mail, shall be deemed to be
the fourth business day after the same shall have been so mailed except in the
case of interruption of postal services for any reason whatever, in which case
the date of receipt shall be the date on which the notice, demand or other
communication is actually received by the addressee.

ARTICLE 4 - EXERCISE OF WARRANTS

SECTION 4.1 - METHOD OF EXERCISE OF WARRANTS

The right to purchase shares conferred by the Warrants may be exercised by the
Holders of such Warrant surrendering it, with a duly completed and executed
subscription form and a bank draft, or certified check, payable to, or to the
order of, the Company, at par, in San Francisco, California, for the purchase
price applicable at the time of surrender in respect of the shares subscribed
for in lawful money of the United States of America, to the Company, at its
principal office in San Francisco, California.

<PAGE>   6

SECTION 4.2 - ALTERNATE METHOD OF EXERCISE

In lieu of exercising Warrants as provided for in Section 4.1 above, the Holders
may elect to receive shares equal to the value of the Warrants (or any portion
thereof) by surrendering the Warrant certificate, together with a notice of such
election, to the Company, at its principal office in San Francisco, California,
in which case the Holders shall be entitled to receive that number of shares of
the Company calculated as follows:

               X  =  Y (A-B)
                       -----
                         A

        where:

               X  =   the number of shares of the Company to be issued to the
                      Holders

               Y  =   the number of Warrants which are being exercised

               A  =   the fair market value of one share of the Company as at
                      the date the notice of exercise is received by the
                      Company; and

               B  =   the exercise price of the Warrants

and for the purposes of this section the "fair market value" of one share of the
Company shall be the average closing price of the Company's shares for the five
trading days immediately preceding the date the notice of exercise is received
by the Company where the Company's shares trade on a recognized stock exchange
or national market system and shall be the average of the mean of the closing
bid and ask prices for such shares for the five trading days immediately
preceding the date the notice of exercise is received by the Company where the
Company's shares trade over-the-counter.

SECTION 4.3 - EFFECT OF EXERCISE OF WARRANTS

(1)     Upon exercise as aforesaid the shares so subscribed for will be deemed
        to have been issued and such person or persons will be deemed to have
        become the holder or holders of record of such shares on the date of
        such surrender and payment, and such shares will be issued at the
        subscription price in effect on the date of such exercise.

(2)     Within ten business days after exercise as aforesaid, the Company will
        forthwith cause to be delivered to the person or persons in whose name
        or names the shares so subscribed for are to be issued as specified in
        such subscription or mailed to him or them at his or their respective
        addresses specified in such subscription, a certificate or certificates
        for the appropriate number of shares not exceeding those which the
        Warrant Holder is entitled to purchase pursuant to the Warrant
        Certificate surrendered.

SECTION 4.4 - SUBSCRIPTION FOR LESS THAN ENTITLEMENT

The Holders of any Warrant certificate may subscribe for, and purchase, a number
of shares less than the number which the Holders are entitled to purchase,
pursuant to the surrendered Warrant. In the event of any purchase of a number of
shares less than the number which can be purchased pursuant to a Warrant
certificate, the Holders, upon exercise thereof, will, in addition, be entitled
to receive, on that same date (the "New Date"), a new Warrant certificate
effective as of the New Date, in respect of the balance

<PAGE>   7

of the shares which the Holders were entitled to purchase pursuant to the
surrendered Warrant certificate and which were not then purchased.

SECTION 4.5 - WARRANTS FOR FRACTIONS OF SHARES

To the extent that the Holders of any Warrant are entitled to receive on the
exercise or partial exercise thereof a fraction of a common share, such right
may be exercised in respect of such fraction only in combination with another
Warrant or other Warrants which in the aggregate entitle the holder to receive a
whole number of such common shares.

SECTION 4.6 - EXPIRATION OF WARRANTS

After the expiration of the period within which a Warrant is exercisable, all
rights thereunder will wholly cease and terminate, and such Warrant will be void
and of no effect.

SECTION 4.7 -TIME OF ESSENCE

Time will be of the essence hereof.

SECTION 4.8 - SUBSCRIPTION PRICE

One Warrant and $0.50, during the term of the Warrants, are required to
subscribe for each share.

SECTION 4.9 - ADJUSTMENT OF EXERCISE PRICE

The exercise price and the number of common shares deliverable upon the exercise
of the Warrants will be subject to adjustment in the event and in the manner
following:

(1)     If, and whenever, the shares at any time outstanding are subdivided into
        a greater or consolidated into a lesser number of shares the exercise
        price will be decreased or increased proportionately as the case may be;
        upon any such subdivision or consolidation the number of shares
        deliverable upon the exercise of the Warrants will be increased or
        decreased proportionately as the case may be.

(2)     (a)     In case of any capital reorganization or of any reclassification
                of the capital of the Company, or in the case of the
                consolidation, merger or amalgamation of the Company with or
                into any other Company (hereinafter collectively referred to as
                a "Reorganization"), each Warrant will after such Reorganization
                confer the right to purchase the number of shares or other
                securities of the Company (or of the Company resulting from such
                Reorganization) which the Warrant Holders would have been
                entitled to upon Reorganization if the Warrant Holders had been
                shareholders at the time of such Reorganization.

        (b)     In any such case, if necessary, appropriate adjustments will be
                made in the application of the provisions of this Article Four
                relating to the rights and interest thereafter of the Holders of
                the Warrants so that the provisions of this Article Four will be
                made applicable as nearly as reasonably possible

<PAGE>   8

                to any shares or other securities deliverable after the
                Reorganization on the exercise of the Warrants.

        (c)     The subdivision or consolidation of shares at any time
                outstanding into a greater or lesser number of shares (whether
                with or without par value) will not be deemed to be a
                Reorganization for the purposes of this paragraph (2).

(3)     The adjustments provided for in this Section are cumulative and will
        become effective immediately after the record date or, if no record date
        is fixed, the effective date of the event which results in such
        adjustments.

SECTION 4.10 - DETERMINATION OF ADJUSTMENTS

If any questions will at any time arise with respect to the exercise price or
any adjustment provided for in Section 4.8, such questions will be conclusively
determined by the Company's Auditors, or, if they decline to so act, any other
firm of chartered accountants, in San Francisco, California that the Company may
designate and who will have access to all appropriate records, and such
determination will be binding upon the Company and the Holders of the Warrants.

ARTICLE 5 - COVENANTS BY THE COMPANY

SECTION 5.1 - RESERVATION OF SHARES

The Company will reserve, and there will remain unissued out of its authorized
capital, a sufficient number of shares to satisfy the rights of purchase
provided for herein and in the Warrants should the Holders of all the Warrants
from time to time outstanding determine to exercise such rights in respect of
all shares which they are or may be entitled to purchase pursuant thereto and
hereto.

SECTION 5.2 - COMPANY MAY PURCHASE

The Company may, from time to time, offer to purchase, and purchase, for
cancellation only, any Warrants in such manner, from such persons, and on such
terms and conditions as it determines.

SECTION 5.3 - REGISTRATION RIGHTS

(1) If the Company determines to register any of its securities for the account
of a shareholder or holders, other than in a registration relating solely to
employee benefit plans, a registration relating solely to a Rule 145
transaction, or a registration on any registration form that does not permit
secondary sales, the Company will (i) promptly give to each person who is a
Warrant Holder at the effective date notice and (ii) use its best efforts to
include in such registration (and any related qualification under blue sky laws
or other compliance), and in any underwriting involved therein, all the
Registerable Securities of such shareholder, as requested, such request to be
made in writing and received by the Company within twenty (20) days after it
delivers its notice of the proposed registration. Such request may specify all
or part of the Holders' Registerable Securities. As used herein, the term
Registerable Securities means shares of the Company's common stock issued or
issuable to the Warrant Holders pursuant hereto.

<PAGE>   9

(2) If any shares issuable as a result of the exercise of Warrants hereunder
cannot be registered as a result of limitations of the aggregate number of
shares of Registerable Securities that may be so included, the number of shares
of Registerable Securities that may be included shall be allocated among the
Holders requesting inclusion of shares, pro rata, on the basis of the number of
shares of Registerable Securities, provided that such allocation shall not
operate to reduce the aggregate number of Registerable Securities that may be
included in such registration if any Holder does not request inclusion of the
maximum number of shares of Registerable Securities allocated to it pursuant to
the procedure described in this section, and the remaining portion of its
allocation shall be reallocated among those requesting Holders whose allocation
did not satisfy the request pro rata on the basis of the number of shares of
Registerable Securities which will be held by such Holders and any selling
shareholders.

(3) Notwithstanding the rights set forth herein, the Company shall have no
registration obligation to any Holder in the event that the Company is advised
by its underwriter or other selling agent that the underwriter is not willing to
register shares issuable pursuant to the Warrants by reason of market conditions
or any other reason relating to the primary obligation of such underwriter or
agent to sell the shares of the Company, its being the intention of the parties
that the Company's ability to sell all of the shares that it wishes to sell
pursuant to any registration statement shall be paramount to, and shall
supersede, the rights of any Holder hereunder.

ARTICLE 6 - WAIVER OF CERTAIN RIGHTS

SECTION 6.1 - IMMUNITY OF SHAREHOLDERS, ETC.

The Warrant Holders, as part of the consideration for the issue of the Warrants,
waive and will not have any right, cause of action or remedy now or hereafter
existing in any jurisdiction against any past, present or future incorporator,
shareholder, Director or Officer (as such) of the Company, for the issue of
shares, pursuant to any Warrant or on any covenant, agreement, representation or
warranty by the Company herein contained or in the Warrant.

ARTICLE 7 - MODIFICATION OF TERMS, MERGER, SUCCESSORS

SECTION 7.1 - MODIFICATION OF TERMS AND CONDITIONS FOR CERTAIN PURPOSES

From time to time, the Company may, subject to the provisions of these presents,
modify the Terms and Conditions hereof, for the purpose of correction or
rectification of any ambiguities, defective provisions, errors or omissions
herein.

SECTION 7.2 - TRANSFERABILITY

The Warrants and all rights attached to them are not transferable or assignable.

DATED this 24th day of October, 2000.

                                      NETSTAFF, INC.

                                       By: /s/PATRICK RYLEE
                                           -----------------------------------
                                           Authorized Signatory<PAGE>   1
                                                                  EXHIBIT 10.130

                                 LOAN AGREEMENT

        THIS LOAN AGREEMENT (the "Agreement") is made as of September __, 2000
by and between PPGx, INC., a Delaware corporation (the "Company") and the
entities whose names appear on the Schedule of Lenders attached hereto as
Exhibit A (the "Lenders").

         1. The Loans.

               1.1 The Loans. Subject to the conditions specified in this
Agreement, each Lender agrees to lend to the Company up to the sum set forth
opposite such Lender's name on Exhibit A (each, a "Credit Line," and
collectively, the "Total Credit Line"). Each month for the next nine months
prior to the Maturity Date (as defined below), the Company may borrow from the
Lenders the principal amount (each a "Loan Amount") up to one million dollars
($1,000,000); provided, however, that the Loan Amount shall be made on a pro
rata basis from the Lenders based on the Pro Rata Percentages set forth on
Exhibit A attached hereto. At the end of each month prior to the Maturity Date,
the Company will inform the Lenders in writing of the next month's Loan Amount
based on the Company's anticipated funding needs for the next month, and each
Lender will provide its Pro Rata Percentage, set forth on Exhibit A attached
hereto, of the Loan Amount on the second business day after receipt of the
notice of the Loan Amount. Each Loan Amount shall be made against the issuance
and delivery by the Company of a promissory note to each Lender for the portion
of the Loan Amount borrowed from each Lender (each a "Note," and collectively,
the "Notes") in substantially the form attached hereto as Exhibit B. The
availability of additional funding under these credit lines will be
automatically cancelled in the event of new external funding provided to the
Company or in case of a sale, merger or other disposition of the Company such
that after such event the Lenders collectively own less than fifty percent (50%)
of the outstanding securities of the Company.

               1.2 Maturity Date. For the purposes of this Agreement, the
Maturity Date shall be the earlier of (i) June 30, 2001, or (ii) a sale, merger
or other disposition of the Company such that after such event the Lenders
collectively own less than fifty percent (50%) of the outstanding securities of
the Company.

               1.3 Repayment. The Company will repay the outstanding principal
and accrued interest of each Note on a pro rata basis, so that each Lender
receives the same principal amount in repayment, and each Lender's share of the
outstanding aggregate Loan Amounts remains in accordance with the Pro Rata
Percentages set forth on Exhibit A attached hereto.

               1.4 Place and Date of Closing. The closing of the transactions
provided for herein (the "Closing") will be held at the offices of
Pharmaceutical product Development, Inc. at 3151 South 17th Street, Wilmington,
NC 28412 on September __, 2000 or at such other time and place as the parties
shall mutually agree (the "Closing Date").

                                       1
<PAGE>   2

               1.5 Delivery. At the Closing, (i) the Company shall execute and
deliver to each Lender this Agreement, and (ii) the Lenders shall each execute
and deliver to the Company this Agreement.

        2. Representations and Warranties of the Company. The Company hereby
represents and warrants to each Lender as follows:

               2.1 Organization and Standing. The Company is a corporation duly
organized and validly existing under, and by virtue of, the laws of the State of
Delaware and is in good standing under such laws. The Company has the requisite
corporate power to own and operate its properties and assets, and to carry on
its business as presently conducted and as proposed to be conducted.

               2.2 Corporate Power. The Company will have at the Closing all
requisite legal and corporate power to execute and deliver this Agreement, to
issue the Notes and to carry out and perform its obligations under the terms of
this Agreement.

               2.3 Consents, Authorizations and Permits. The Company will have
obtained prior to the Closing any and all consents, authorizations and permits
appropriate or required in connection with the issuance of the Notes and
performance of the Company's obligations under the terms of this Agreement
(except for such consents, authorizations and permits that may be properly
obtained subsequent to the Closing).

               2.4 Authorization. The execution, delivery and performance of
this Agreement by the Company has been duly authorized by all requisite
corporate action, and constitutes the valid and binding obligation of the
Company, enforceable against the Company in accordance with its terms, subject
to applicable bankruptcy, insolvency, reorganization, or similar laws relating
to or affecting the enforcement of creditors' rights.

        3. Defaults and Remedies.

               3.1 Events of Default. The following events shall be considered
Events of Default with respect to each Note:

                   (a) The Company shall default in the payment of any part of
the principal or accrued and unpaid interest on the Note for more than thirty
(30) days after the same shall become due and payable, whether at maturity or at
a date fixed for prepayment or otherwise;

                   (b) The Company shall make an assignment for the benefit of
creditors, or shall admit in writing its inability to pay its debts as they
become due, or shall file a voluntary petition for bankruptcy, or shall file any
petition or answer seeking for itself any reorganization, arrangement,
composition, readjustment, dissolution or similar relief under any present or
future statute, law or regulation, or shall file any answer admitting the
material allegations of a petition filed against the Company in any such
proceeding, or shall seek or

                                       2
<PAGE>   3

consent to or acquiesce in the appointment of any trustee, receiver or
liquidator of the Company, or of all or any substantial part of the properties
of the Company, or the Company or its respective directors or majority
shareholders shall take any action looking to the dissolution or liquidation of
the Company; or

                   (c) Within sixty (60) days after the commencement of any
proceeding against the Company seeking any reorganization, arrangement,
composition, readjustment, liquidation, dissolution or similar relief under any
present or future statute, law or regulation, such proceeding shall not have
been dismissed or, within sixty (60) days after the appointment without the
consent or acquiescence of the Company of any trustee, receiver or liquidator of
the Company or of all or any substantial part of the properties of the Company,
such appointment shall not have been vacated.

               3.2 Remedies. Upon the occurrence of an Event of Default under
Section 5.1 hereof, at the option and upon the declaration of the holder of the
Note, (i) the entire unpaid principal and accrued and unpaid interest on the
Note held by such holder shall, without presentment, demand, protest, or notice
of any kind, all of which are hereby expressly waived, be forthwith due and
payable, (ii) such holder may, immediately and without expiration of any period
of grace, enforce payment of all amounts due and owing under such Note and
exercise any and all other remedies granted to it at law, in equity, or
otherwise and (iii) the Applicable Rate (as defined in the form of Note attached
hereto as Exhibit B) will automatically change to the Default Rate of twelve
percent (12%) compounded quarterly in arrears.

        4. Miscellaneous.

               4.1 Waivers and Amendments. With the written consent of the
record holders of more than fifty percent (50%) of the aggregate Loan Amounts
then outstanding, the obligations of the Company and the rights of the holders
of the aggregate Loan Amounts under this Agreement may be waived (either
generally or in a particular instance, either retroactively or prospectively and
either for a specified period of time or indefinitely), and with the same
consent the Company, when authorized by resolution of its Board of Directors,
may enter into a supplementary agreement for the purpose of adding any
provisions to or changing in any manner or eliminating any of the provisions of
this Agreement; provided, however, that (i) no such waiver or supplemental
agreement shall reduce the above percentage of aggregate Loan Amounts, the
holders of which are required to consent to any waiver or supplemental
agreement, without the consent of the record or beneficial holders of all of the
aggregate Loan Amounts and (ii) no such waiver or supplemental agreement shall
vary the terms of the Notes (including without limitation the provisions of this
Agreement incorporated by reference into the Notes) without the consent of the
holder of the Note affected by such proposed waiver or supplemental agreement.
Upon the effectuation of each such waiver, consent, agreement, amendment or
modification the Company shall promptly give written notice thereof to the
record holders of the aggregate Loan Amounts who have not previously consented
thereto in writing. Neither this Agreement nor any provisions hereof may be
changed, waived, discharged or terminated orally, but only by a signed statement
in writing.

                                       3
<PAGE>   4

               4.2 Governing Law. This Agreement shall be governed in all
respects by the laws of the State of Delaware as such laws are applied to
agreements between Delaware residents entered into and to be performed entirely
within Delaware.

               4.3 Survival. The representations, warranties, covenants and
agreements made herein shall survive for a period of one year following the
Closing Date.

               4.4 Successors and Assigns. Except as otherwise expressly
provided herein, the provisions hereof shall inure to the benefit of, and be
binding upon, the successors, assigns, heirs, executors and administrators of
the parties hereto.

               4.5 Entire Agreement. This Agreement and the other documents
delivered pursuant hereto constitute the full and entire understanding and
agreement between the parties with regard to the subjects hereof and thereof.

               4.6 Severability of this Agreement. In case any provision of this
Agreement shall be deemed to be invalid, illegal or unenforceable, the validity,
legality and enforceability of the remaining provisions shall not in any way be
affected or impaired thereby.

               4.7 Titles and Subtitles. The titles of the Sections and
Subsections of this Agreement are for convenience of reference only and are not
to be considered in construing this Agreement.

               4.8 Delays or Omissions. It is agreed that no delay or omission
to exercise any right, power or remedy accruing to the Lender, upon any breach
or default of the Company under this Agreement or the Notes, shall impair any
such right, power or remedy, nor shall it be construed to be a waiver of any
such breach or default, or any acquiescence therein, or of any similar breach or
default thereafter occurring; nor shall any waiver of any single breach or
default be deemed a waiver of any other breach or default theretofore or
thereafter occurring. It is further agreed that any waiver, permit, consent or
approval of any kind or character by the Lender of any breach or default under
this Agreement, or any waiver by the Lender of any provisions or conditions of
this Agreement must be in writing and shall be effective only to the extent
specifically set forth in writing and that all remedies, either under this
Agreement, or by law or otherwise afforded to the Lender, shall be cumulative
and not alternative.

               4.9 Notices. Any notice or report required in this Agreement or
permitted to be given shall be given by depositing the same in the United States
mail, postage prepaid and addressed to the parties as follows:

                      To the Company:

                      PPGx, Inc.
                      3500 Paramount Parkway
                      Morrisville, NC 27560
                      Attn:  Josh Baker, President & CEO

                                       4
<PAGE>   5

                      To the Lenders:

                      At their respective addresses set forth on Exhibit A

               4.10 Counterparts. This Agreement may be executed by facsimile
and in any number of counterparts, each of which shall be deemed an original,
and all of which together shall constitute one instrument.

               IN WITNESS WHEREOF, the parties have caused this Loan Agreement
to be duly executed and delivered as of the day and year first written above.

                           [Signature Pages to Follow]

                                       5
<PAGE>   6

THE COMPANY:                          PPGx, INC.

                                      By:
                                         ---------------------------------------
                                      Name:
                                           -------------------------------------
                                                (print)
                                      Title:
                                            ------------------------------------
                                      Address:  3500 Paramount Parkway
                                                Morrisville, NC 27560

LENDERS:                              AXYS PHARMACEUTICALS, INC.

                                      By:
                                         ---------------------------------------
                                      Name:
                                           -------------------------------------
                                                        (print)
                                      Title:
                                            ------------------------------------

                                      Address:  180 Kimball Way
                                                S. San Francisco, CA 94080

                                      PHARMACEUTICAL PRODUCT DEVELOPMENT, INC.

                                      By:
                                         ---------------------------------------

                                      Name:
                                           -------------------------------------
                                                (print)
                                      Title:
                                            ------------------------------------

                                      Address:  3151 South 17th Street
                                                Wilmington, NC 28412

                                       6
<PAGE>   7

                                    EXHIBIT A

                               SCHEDULE OF LENDERS
<TABLE>
<CAPTION>

-------------------------------------------------------------------------------------------------
                   LENDER                            CREDIT LINE           PRO RATA PERCENTAGE
-------------------------------------------------------------------------------------------------
<S>                                                 <C>                    <C>
Axys Pharmaceuticals, Inc.                          $3,150,000.00                  50%
180 Kimball Way
S. San Francisco, CA 94080
Attn: William J. Newell
-------------------------------------------------------------------------------------------------
Pharmaceutical Product Development, Inc.            $3,150,000.00                  50%
3151 South 17th Street
Wilmington, NC 28412
Attn: Fred Davenport, General Counsel
-------------------------------------------------------------------------------------------------

TOTAL                                               $6,300,000.00
-------------------------------------------------------------------------------------------------
</TABLE>

                                      A-1
<PAGE>   8

                                    EXHIBIT B

Date: September ____, 2000                                                $--

                                      PPGx

                                 PROMISSORY NOTE

        PPGx, Inc., a Delaware corporation ("Company"), for value received,
promises to pay to -- or its assigns (the "Lender"), the principal sum of
$--, in lawful money of the United States of America and in immediately
available funds, plus interest on the principal amount hereof, at the Applicable
Rate per annum. All accrued interest is payable at maturity. All principal and
accrued interest shall be due and payable on the Maturity Date. Interest shall
be computed on the basis of a year of 365 days for the actual number of days
elapsed.

        1. Definitions. Unless the context indicates otherwise, capitalized
terms used herein shall have the meanings given them in the Loan Agreement,
provided that the following terms used herein shall have the following meanings:

               1.1 "Loan Agreement" means the Loan Agreement dated as of
September _____, 2000 among the Lender, the Company and the other Lender.

               1.2 "Lenders" means the lenders whose names appear on the
Schedule of Lenders attached to the Loan Agreement as Exhibit A thereto.

               1.3 "Noteholder," "holder," or similar terms, when the context
refers to a holder of a Note, means any person who shall at the time be the
holder of this Note.

               1.4 "Applicable Rate" means 8% per annum, compounded quarterly.

               1.5 "Default Rate" means 12% per annum, compounded quarterly.

        2. No Prepayment Penalty. The principal amount of, and accrued and
unpaid interest on, this Note may be paid by the Company in whole or in part at
any time prior to maturity without penalty, provided however, the Company must
give the Lenders five (5) working days prior notice, and the prepaid amount
shall be divided in accordance with the respective Pro Rata Percentages of such
Lenders set forth on the Schedule of Lenders attached to the Loan Agreement as
Exhibit A thereto.

        3. Subordination. This Note is a general unsecured obligation of the
Company and is subordinated in right of payment to all indebtedness of the
Company to First Union National Bank for bank loans outstanding on the date
hereof, except for any such loan that by its terms is junior in right of payment
to this Note or is pari passu in right of payment to this Note.

                                      B-1
<PAGE>   9

        4. Attorneys' Fees and Costs. If any amount is not paid as and when due
hereunder, the Company promises to pay all costs of collection and reasonable
attorneys' fees which the Lenders may incur.

        5. Transferability. This Note may not be transferred in whole or in part
without the prior written consent of the Company and the Lenders.

        6. Loan Agreement. This Note is a Note as defined in the Loan Agreement
and is entitled to all the benefits provided therein. Reference is made to said
Loan Agreement for the Events of Default and the rights of acceleration of the
maturity upon an Event of Default.

        7. Governing Law. This terms and conditions of this Note shall be
governed in all respects by the laws of the State of Delaware as such laws are
applied to agreements between Delaware residents entered into and to be
performed entirely within Delaware.

                                      PPGx, INC.

                                      ------------------------------------------
                                      By:
                                         ---------------------------------------
                                      Its:
                                          --------------------------------------

                                      B-2

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