Document:

Prepared by R.R. Donnelley Financial -- Office Building Lease dated May 3, 2004

 Exhibit 10.10 
  

  
 OFFICE BUILDING LEASE 
  
 by and between 
  
 WOODSIDE TECHNOLOGY CENTER, LLC, 
 a Delaware limited liability
company 
  
 and 
  
 FOXHOLLOW TECHNOLOGIES,
INC., 
 a Delaware corporation 
  

 TABLE OF CONTENTS 
  

					
	 	  	 	  	Page

	 ARTICLE 1
	  	 	  	 
	 	  	 Definitions
	  	1
	 1.01
	  	 “Additional Rent”
	  	1
	 1.02
	  	 “Base Rent”
	  	1
	 1.03
	  	 “Building”
	  	1
	 1.04
	  	 “Building Operating Cost”
	  	1
	 1.05
	  	 “Building Operating Cost Adjustment”
	  	1
	 1.06
	  	 “Building Standard Improvements”
	  	1
	 1.07
	  	 “Building Systems”
	  	1
	 1.08
	  	 “business day”
	  	1
	 1.09
	  	 “Common Areas”
	  	2
	 1.10
	  	 “Customary Use”
	  	2
	 1.11
	  	 “Estimated Building Operating Cost”
	  	2
	 1.12
	  	 “Estimated Project Operating Cost”
	  	2
	 1.13
	  	 “Fair Market Rent”
	  	2
	 1.14
	  	 “Force Majeure Events”
	  	2
	 1.15
	  	 “Gross Rent”
	  	2
	 1.16
	  	 “Hazardous Material”
	  	2
	 1.17
	  	 “Hazardous Materials Claims”
	  	3
	 1.18
	  	 “Hazardous Materials Laws”
	  	3
	 1.19
	  	 “Landlord Affiliates”
	  	3
	 1.20
	  	 “Landlord Delays”
	  	3
	 1.21
	  	 “Landlord Parties”
	  	3
	 1.22
	  	 “Leased Premises”
	  	3
	 1.23
	  	 “Letter of Credit”
	  	4
	 1.24
	  	 “Major Vertical Penetrations”
	  	4
	 1.25
	  	 “Permitted Hazardous Materials”
	  	4
	 1.26
	  	 “Permitted Use”
	  	4
	 1.27
	  	 “Project”
	  	4
	 1.28
	  	 “Project Operating Cost”
	  	4
	 1.29
	  	 “Rent”
	  	5
	 1.30
	  	 “Substantial Completion”
	  	5
	 1.31
	  	 “Tenant Extra Improvements”
	  	5
	 1.32
	  	 “Tenant Improvements”
	  	5
	 1.33
	  	 “Tenant Parties”
	  	5
	 1.34
	  	 “Tenant-Specific Hazardous Materials”
	  	5
	 1.35
	  	 “Term”
	  	5
	 1.36
	  	 “Term Commencement Date”
	  	5
	 1.37
	  	 “Term Expiration Date”
	  	6
			
	 ARTICLE 2
	  	 	  	 
	 	  	 Leased Premises
	  	6
	 2.01
	  	 Lease
	  	6
	 2.02
	  	 Landlord’s Reserved Rights
	  	6

					
	 	  	 	  	Page

	 ARTICLE 3
	  	 	  	 
	 	  	 Rent, Term, Use and Building Operating Costs
	  	7
	 3.01
	  	 Term
	  	7
	 3.02
	  	 Use
	  	7
	 3.03
	  	 Payment of Base Rent and Estimated Building Operating Cost
	  	8
	 3.04
	  	 Net Lease
	  	8
	 3.05
	  	 Project Operating Cost
	  	8
	 3.06
	  	 Allocation of Building Operating Cost
	  	13
	 3.07
	  	 Adjustment For Variation Between Estimated and Actual
	  	13
	 3.08
	  	 Computation of Building Operating Cost Adjustment
	  	14
	 3.09
	  	 Tenant’s Audit Right
	  	14
			
	 ARTICLE 4
	  	 	  	 
	 	  	 Landlord Covenants
	  	16
	 4.01
	  	 Landlord’s Repair and Maintenance
	  	16
	 4.02
	  	 Landlord’s Right to Perform
	  	17
	 4.03
	  	 Exculpation
	  	17
	 4.04
	  	 Graphics and Signage
	  	17
	 4.05
	  	 Peaceful Enjoyment
	  	18
			
	 ARTICLE 5
	  	 	  	 
	 	  	 Tenant’s Covenants
	  	18
	 5.01
	  	 Payments By Tenant
	  	18
	 5.02
	  	 Construction of Tenant Improvements
	  	18
	 5.03
	  	 Utilities
	  	19
	 5.04
	  	 Taxes On Personal Property, Tenant Extra Improvements and Alterations
	  	19
	 5.05
	  	 Repairs By Tenant
	  	19
	 5.06
	  	 Waste
	  	20
	 5.07
	  	 Assignment or Sublease
	  	20
	 5.08
	  	 Alterations, Additions or Improvements
	  	23
	 5.09
	  	 Liens
	  	24
	 5.10
	  	 Compliance With Laws, Insurance Standards and Non-Discrimination
	  	25
	 5.11
	  	 Entry For Repairs, Inspection, Posting Notices, Etc.
	  	26
	 5.12
	  	 No Nuisance
	  	26
	 5.13
	  	 Subordination; Mortgagee Protection; Reciprocal Easement Agreements
	  	27
	 5.14
	  	 Estoppel Certificate
	  	28
	 5.15
	  	 Letter of Credit
	  	28
	 5.16
	  	 Tenant’s Remedies
	  	31
	 5.17
	  	 Rules and Regulations
	  	31
	 5.18
	  	 Prohibition and Indemnity With Respect To Hazardous Material
	  	32
	 5.19
	  	 Surrender of Premises On Termination
	  	33
	 5.20
	  	 Window Coverings
	  	34

					
	 	  	 	  	Page

	 ARTICLE 6
	  	 	  	 
	 	  	 Condition and Operation of the Building
	  	34
	 6.01
	  	 As-Is Condition
	  	34
	 6.02
	  	 Alteration
	  	35
			
	 ARTICLE 7
	  	 	  	 
	 	  	 Casualty, Eminent Domain and Miscellaneous Matters
	  	36
	 7.01
	  	 Landlord’s Casualty Insurance
	  	36
	 7.02
	  	 Liability Insurance
	  	36
	 7.03
	  	 Tenant’s Casualty Insurance and Additional Tenant Insurance Requirements
	  	36
	 7.04
	  	 Indemnity and Exoneration
	  	37
	 7.05
	  	 Waiver of Subrogation Rights
	  	38
	 7.06
	  	 Condemnation
	  	38
	 7.07
	  	 Damage and Destruction
	  	39
	 7.08
	  	 Default By Tenant
	  	40
	 7.09
	  	 Option to Extend the Term at Fair Market Rent
	  	43
	 7.10
	  	 No Waiver
	  	45
	 7.11
	  	 Statutory Waivers
	  	46
	 7.12
	  	 Holding Over
	  	46
	 7.13
	  	 Attorneys’ Fees
	  	46
	 7.14
	  	 Amendments
	  	47
	 7.15
	  	 Transfers By Landlord
	  	47
	 7.16
	  	 Severability
	  	47
	 7.17
	  	 Notices
	  	47
	 7.18
	  	 No Option
	  	47
	 7.19
	  	 Integration and Interpretation
	  	47
	 7.20
	  	 Quitclaim
	  	47
	 7.21
	  	 No Easement For Light, Air and View
	  	48
	 7.22
	  	 No Merger
	  	48
	 7.23
	  	 Memorandum of Lease
	  	48
	 7.24
	  	 Survival
	  	48
	 7.25
	  	 Financial Statements
	  	48
	 7.26
	  	 No Joint Venture
	  	49
	 7.27
	  	 Successors and Assigns
	  	49
	 7.28
	  	 Applicable Law
	  	49
	 7.29
	  	 Time of the Essence
	  	49
	 7.30
	  	 Interpretation
	  	49
	 7.31
	  	 Parking
	  	49
	 7.32
	  	 Brokers
	  	49
	 7.33
	  	 Reasonable Expenditures
	  	50
	 7.34
	  	 Right to Cure
	  	50
	 7.35
	  	 Approvals
	  	50

 Basic Lease Information 
  

							
		
	 Date:
	 	May 3, 2004
		
	 Tenant:
	 	FoxHollow Technologies, Inc.
		
	 Address:
	 	740 Bay Road
Redwood City, California 94085
		
	 Landlord:
	 	Woodside Technology Center, LLC
		
	 Address:
	 	c/o Hines 651 Gateway Boulevard, Suite 1140
South San Francisco, California 94080
		
	 Leased Premises:
	 	740 Bay Road, located within the Woodside Technology Center
		
	 Rentable Square Footage:
	 	60,985 square feet
		
	 Scheduled Term Commencement Date:
	 	September 1, 2004
		
	 Scheduled Term Expiration Date:
	 	August 31, 2011
		
	 Term:
	 	Eighty-four (84) months
				
	Base Rent:	 	Months of Term

	  	Monthly Base Rate

	  	Monthly Base Rent

	 	 	  1 - 12	  	$1.00	  	$60,985.00
	 	 	13 - 24	  	$1.05	  	$64,034.25
	 	 	25 - 36	  	$1.10	  	$67,083.50
	 	 	37 - 48	  	$1.15	  	$70,132.75
	 	 	49 - 60	  	$1.20	  	$73,182.00
	 	 	61 - 72	  	$1.25	  	$76,231.25
	 	 	73 - 84	  	$1.30	  	$79,280.50
		
	 Letter of Credit:
	 	Five Hundred Thirty Thousand Five Hundred Sixty-Nine and
50/100 Dollars ($530,569.50)
		
	 Landlord’s Contribution:
	 	Six Hundred Nine Thousand Eight Hundred Fifty Dollars
($609,850.00) (viz., $10.00 per rentable square foot)
		
	 Tenant Improvements Loan:
	 	Up to Three Hundred Four Thousand Nine Hundred Twenty-Five
Dollars ($304,925.00) (viz., $5.00 per rentable square foot)
		
	 Broker:
	 	Cornish & Carey Commercial
		
	 Option to Renew:
	 	One (1) option of five (5) consecutive years

  

 WOODSIDE TECHNOLOGY CENTER 
  
 This Lease is made and entered into as of the date specified in the Basic
Lease Information Sheet attached hereto and incorporated herein by this reference, by and between WOODSIDE TECHNOLOGY CENTER, LLC, a Delaware limited liability company
(“Landlord”), and the Tenant identified in the Basic Lease Information Sheet. 
  
 IN CONSIDERATION OF THE MUTUAL COVENANTS AND AGREEMENTS CONTAINED
IN THIS LEASE, THE PARTIES AGREE AS FOLLOWS: 
  
 ARTICLE 1 
  
 Definitions 
  
 Certain terms used in this Lease and the Exhibits hereto shall have the meaning set forth below for each such term. Certain other terms shall have the
meaning set forth elsewhere in this Lease and the Exhibits hereto. 
  
 1.01 “Additional Rent” shall mean all payment obligations of Tenant hereunder other than the obligation for payment of Gross Rent. 
  
 1.02 “Base Rent” shall mean the basic rent payable by Tenant to Landlord in the amounts shown
on the Basic Lease Information sheet and in the manner provided in Section 3.03. 
  
 1.03 “Building” shall mean the improvements known as 740 Bay Road located in Redwood City, California. 
  
 1.04 “Building Operating Cost” shall mean the portion of the Project Operating Cost which is
allocated to the Building pursuant to Section 3.06. 
  
 1.05
“Building Operating Cost Adjustment” for any calendar year shall mean the difference, if any, between Estimated Building Operating Cost and Building Operating Cost for that calendar year. 
  
 1.06 “Building Standard Improvements” shall
mean those improvements of the Leased Premises that are of the type and quality so defined in Exhibit E, or such other standards for a particular item selected from time to time by Landlord for the Building. 
  
 1.07 “Building Systems” shall mean all
mechanical, electrical, HVAC, life safety or other systems of the Building. 
  
 1.08 “business day” shall mean Monday through Friday, except holidays; “holiday” means those holidays specified by the laws of the United States or the State of
California and all holidays to which maintenance employees of the Building are entitled from time to time under their union contract or other agreement. At the request of Tenant, a current list of Building holidays shall be provided by Landlord on
an annual basis in January of each year of the Term. Landlord shall have the right to change the holiday schedule from time to time by written notice to Tenant. 
  

 1 

 1.09 “Common Areas” shall mean all walkways, roadways, sidewalks,
parkways, driveways, parking areas, parking structures, landscaped areas or other similar facilities maintained for the benefit of Project tenants and invitees. 
  

1.10 “Customary Use” shall mean legally permitted uses that are similar to the uses for which other buildings in the
general vicinity of the Project are generally being occupied by medical devices companies from time to time. 
  
 1.11 “Estimated Building Operating Cost” for any calendar month shall mean the portion of the Estimated Project Operating
Cost which Landlord estimates to be allocable to the Building pursuant to Section 3.06 for such calendar month. 
  
 1.12 “Estimated Project Operating Cost” for any calendar month shall mean Landlord’s estimate of Project Operating
Cost for the calendar year within which such month falls divided by twelve (12) equal monthly installments. 
  
 1.13 “Fair Market Rent” shall mean the prevailing market rate for the Leased Premises, taking into account the rates being
charged for comparable space within high-quality commercial office and laboratory properties comparable to the Project located in central and southern San Mateo County, including, without limitation, the rate being charged by Landlord for comparable
space within the Project, taking into consideration: location in the Building, tenant improvements or allowances existing or to be provided, rental abatements, lease takeovers/assumptions, moving expenses and other forms of rental concessions,
proposed term of lease, extent of service provided or to be provided, the ownership of the comparable space, whether or not the transaction is a sublease, the time the particular rate under consideration became or is to become effective and any
other relevant terms or conditions. 
  
 1.14 “Force
Majeure Events” means casualty events (i.e., acts of God) not resulting from the acts of Tenant or the Tenant Parties. 
  
 1.15 “Gross Rent” shall mean the total of Base Rent and Estimated Building Operating Cost. 
  
 1.16 “Hazardous Material” shall mean
any: (a) oil, flammable substances, explosives, radioactive materials, hazardous wastes or substances, toxic wastes or substances or any other wastes, materials or pollutants which (i) pose a hazard to the Project or to persons on or about the
Project or (ii) cause the Project to be in violation of any Hazardous Materials Laws; (b) asbestos in any form, urea formaldehyde foam insulation, transformers or other equipment that contain dielectric fluid containing levels of polychlorinated
biphenyls, or radon gas; (c) chemical, material or substance defined as or included in the definition of “hazardous substances”, “hazardous wastes”, “hazardous materials”, “extremely hazardous waste”,
“restricted hazardous waste”, or “toxic substances” or words of similar import under any applicable local, state or federal law or under the regulations adopted or publications promulgated pursuant thereto, including, but not
limited to, the Comprehensive Environmental Response, Compensation and Liability Act of 1980, as amended, 42 U.S.C. §9601, et seq.; the 
  

 2 

 Hazardous Materials Transportation Act, as amended, 49 U.S.C. §1801, et seq.; the Federal Water Pollution
Control Act, as amended, 33 U.S.C. §1251, et seq.; Sections 25115, 25117, 25122.7, 25140, 25249.8, 25281, 25316, and 25501 of the California Health and Safety Code; (d) other chemical, material or substance, exposure to which is
prohibited, limited or regulated by any governmental authority or may or could pose a hazard to the health and safety of the occupants of the Project or the owners and/or occupants of property adjacent to or surrounding the Project, or any other
person coming upon the Project or adjacent property; and (e) other chemicals, materials or substances which may or could pose a hazard to the environment. 
  
 1.17 “Hazardous Materials Claims” shall mean any enforcement, cleanup, removal, remedial or other governmental or
regulatory actions, agreements or orders instituted pursuant to any Hazardous Materials Laws; and any claims made by any third party against Landlord, Tenant or the Project relating to damage, contribution, cost recovery, compensation, loss or
injury resulting from the presence, release or discharge of any Hazardous Materials. 
  
 1.18 “Hazardous Materials Laws” shall mean any federal, state or local laws, ordinances, orders, rules, regulations or policies, now or hereafter in force, as amended from time to time,
in any way relating to the environment, health and safety, and Hazardous Materials (including, without limitation, the use, handling, transportation, production, disposal, discharge or storage thereof) or to industrial hygiene or the environmental
conditions on, under or about the Project, including, without limitation, soil, groundwater and indoor and ambient air conditions. Landlord hereby notifies Tenant in accordance with California Health & Safety Code Section 25359.7 that the
Project is the subject of a state-supervised cleanup of hazardous waste disposed of on the site by prior occupants and in connection therewith, and a no further action letter was issued by the Bay Area Regional Water Quality Board on July 18, 1997.
Landlord shall provide to Tenant a letter describing the current condition of the Project, the history of contamination of the Project, the process of any ongoing remediation, and the ownership of any existing problems. 
  
 1.19 “Landlord Affiliates” means any persons
or entities controlling, controlled by or under common control with the named Landlord herein. 
  
 1.20 “Landlord Delays” means any actual delay in the construction of the Tenant Improvements caused solely or primarily by the failure of Landlord to respond to Tenant’s submittal
of Conceptual Plans and Working Drawings within the periods set forth in Paragraphs 3 and 4, respectively, of Exhibit D. 
  
 1.21 “Landlord Parties” means the employees, agents, contractors, officers, directors, partners, licensees, invitees and
guests of Landlord, Landlord Affiliates, Landlord’s manager and members and their respective members, managers, shareholders, general partners and limited partners. 
  
 1.22 “Leased Premises” shall mean the floor area more particularly shown on the floor plans
attached hereto as Exhibit A, containing the rentable square footage specified on the Basic Lease Information sheet. 
  

 3 

 1.23 “Letter of Credit” shall mean the irrevocable standby letter of
credit in the face amount specified in the Basic Lease Information sheet to be delivered by Tenant to Landlord to be held pursuant to Section 5.15 below. 
  
 1.24 “Major Vertical Penetrations” shall mean the area or areas within Building stairs (excluding the landing at each
floor), elevator shafts, flues, vents, stacks, pipe shafts and vertical ducts and the like, that service more than one floor of the Building. The area with Major Vertical Penetrations shall be bounded and defined by the interior surface of the
perimeter walls thereof (or the extended plane of such walls over areas that are not enclosed). Major Vertical Penetrations shall exclude, however, areas for the specific use of Tenant or installed at the request of Tenant, such as special stairs or
elevators. 
  
 1.25 “Permitted Hazardous
Materials” shall mean Hazardous Materials which are contained in ordinary office supplies of a type and in quantities typically used in the ordinary course of business within executive offices of similar size and location, but
only if and to the extent that such Hazardous Materials are transported, stored and used in full compliance with all Hazardous Materials Laws and otherwise in a safe and prudent manner. Any such Hazardous Materials which are transported, stored and
used in a manner which is not in full compliance with all Hazardous Materials Laws or which is not in any respect safe and prudent shall not be deemed to be “Permitted Hazardous Materials” for the purposes of this Lease. 

 
 1.26 “Permitted Use” shall mean (i)
executive, professional office, and corporate administrative office uses, (ii) research and development and laboratory uses (including, without limitation, clean room, wet lab), (iii) manufacturing and machine shop uses for a medical devices company
or a company engaged in the life sciences field (collectively, a “Life Sciences Company”), (iv) assembly and testing uses for a Life Sciences Company, and (v) warehouse, packing, shipping and receiving uses, each of a kind
appropriate in a building of the type and quality of the Building; provided, however, that for the purpose of limiting the type of use permitted by Tenant, or an assignee of Tenant, but without limiting Landlord’s right to lease any portion of
the Project to a tenant of Landlord’s choice, “Permitted Use” shall not include (i) offices of any agency or bureau of the United States or any state or political subdivision thereof, (ii) offices or agencies of any foreign
government or political subdivision thereof, (iii) offices of any health care professionals or service organization, except for administrative offices where no diagnostic, treatment or laboratory services are performed, (iv) schools or other
training facilities that are not ancillary to executive, professional or corporate administrative office use, (v) retail or restaurant uses, (vi) broadcast studios or other broadcast production facilities, such as radio and/or television stations,
(vii) product display or demonstration facilities, (viii) offices at which deposits or bills are regularly paid in person by customers, and (ix) personnel agencies, except offices of executive search firms. 
  
 1.27 “Project” shall mean the real property
(including, without limitation, the Building, the Common Areas and any other present or hereafter existing improvements), as such real property may be expanded from time to time by Landlord, situated in the City of Redwood City, County of San Mateo
and more particularly described on Exhibit B. 
  
 1.28 “Project Operating Cost” shall have the meaning given in Section 3.05. 
  

 4 

 1.29 “Rent” shall mean Gross Rent, Additional Rent and any and all other
charges of any nature payable by Tenant to Landlord under this Lease. 
  
 1.30 “Substantial Completion” shall mean (and the Leased Premises shall be deemed “Substantially Complete”) when (i) installation of Tenant Improvements has occurred, (ii) Tenant has direct
access to the elevator lobby on the floor (or floors) where the Leased Premises are located, (iii) Basic Services are available to the Leased Premises, and (iv) to the extent applicable, Tenant has received electrical, plumbing, mechanical and fire
protection final approval for the Leased Premises from the City of Redwood City, California. Substantial Completion shall be deemed to have occurred notwithstanding a requirement to complete “punchlist” or similar corrective work.

  
 1.31 “Tenant Extra
Improvements” shall mean the extent to which the Tenant Improvements in the Leased Premises would exceed in quality or quantity the Building Standard Improvements. In instances where this Lease refers to Tenant Extra Improvements
as a standard for the provision of services, maintenance, repair or replacement by Tenant or Landlord, such reference shall be to the difference in required services, maintenance, repairs or replacements between the Tenant Improvements as
constructed in the Leased Premises and the Building Standard Improvements, had the Building Standard Improvements been constructed in the Leased Premises. 
  
 1.32 “Tenant Improvements” shall mean the Building Standard Improvements and Tenant Extra Improvements (if any) installed
by or to be installed for Tenant as approved by Landlord pursuant to Exhibit D. 
  
 1.33 “Tenant Parties” shall mean the employees, agents, contractors, officers, directors, partners, licensees, invitees and guests of Tenant. 
  
 1.34 “Tenant-Specific Hazardous Materials”
shall mean Hazardous Materials in reasonable quantities which are necessary for the operation of Tenant’s business in the Leased Premises, but only if and to the extent that such Hazardous Materials are transported, stored and used in full
compliance with all Hazardous Materials Laws and otherwise in accordance with the Handling Recommendations (as defined in Section 5.18(b) below). Any such Hazardous Materials which are transported, stored and used in a manner which is not in full
compliance with all Hazardous Materials Laws and the Handling Recommendations shall not be deemed to be “Tenant-Specific Hazardous Materials” for the purposes of this Lease. 
  
 1.35 “Term” shall mean the period from the
Term Commencement Date and ending on the Term Expiration Date. The Scheduled Term Commencement Date stated on the Basic Lease Information sheet represents merely the parties’ estimate of the Term Commencement Date; provided, however, that in no
event shall the Term Commencement Date occur later than the Scheduled Term Commencement Date. 
  
 1.36 “Term Commencement Date” shall mean the date when the Term commences as determined pursuant to Section 3.01 below. 
  

 5 

 1.37 “Term Expiration Date” shall mean the date that is the number of
years and/or months set forth on the Basic Lease Information after the Term Commencement Date or such earlier date upon which this Lease is terminated pursuant to the terms hereof. 
  
 ARTICLE 2 
  
 Leased Premises 
  

	 	2.01	Lease. 

  
 (a) Landlord leases to Tenant and Tenant leases from Landlord the Leased Premises upon all of the terms, covenants and conditions set forth herein.

  
 (b) Notwithstanding the terms of Section 2.01(a) above or any
other provision of this Lease to the contrary, Tenant shall occupy and shall pay Base Rent and Building Operating Costs on only thirty thousand (30,000) rentable square feet of the Leased Premises during the initial twelve (12) months of the Term
(the “Initial Period”), which area shall be designated by Tenant and approved by Landlord in writing in its reasonable discretion prior to the Term Commencement Date. If, notwithstanding the foregoing, more than thirty thousand
(30,000) rentable square feet of the Leased Premises are occupied during the Initial Period, then Tenant shall pay Base Rent and Building Operating Costs on the actual square footage occupied (which shall include, in addition to square footage
actually occupied by Tenant, square footage that is subleased to or otherwise occupied by a third party). Commencing on the first day following the Initial Period, Tenant shall pay Base Rent and Building Operating Costs on the entirety of the Leased
Premises, irrespective of the area actually occupied by Tenant from time to time. Nothing contained in this Section 2.01(b) shall be construed to permit Tenant to enter into a sublease or assignment of this Lease other than in strict accordance with
the terms of Section 5.07 below. 
  

	 	2.02	Landlord’s Reserved Rights. 

  
 (a) Landlord reserves from the leasehold estate hereunder, in addition to all other rights reserved by Landlord under this Lease: (i) the roof of the
Building (except that Landlord grants specific roof access and rights to Tenant as from time to time may be required to install such additional roof top mounted HVAC equipment (the “Roof Top Equipment”) necessary to support
Tenant’s installation, operation, use and maintenance of such clean room space within the Leased Premises; provided, however, that no such equipment shall be installed until Landlord has reasonably approved in writing such equipment and the
method of installation), (ii) all exterior walls and windows bounding the Leased Premises, and all space located within the Leased Premises for Major Vertical Penetrations, conduits, electric and all other Utilities, air-conditioning, sinks or other
Building facilities that do not constitute Tenant Extra Improvements, the use thereof and access thereto through the Leased Premises for operation, maintenance, repair or replacement thereof, and (iii) the right from time to time, without
unreasonable interference with Tenant’s use and parking rights, to install, remove or relocate any of the foregoing for service to any part of the Building to locations that will not materially interfere with Tenant’s use of the Leased
Premises, to make alterations to the Building, to alter or relocate 
  

 6 

 any portion of the Common Areas or any other common facility, and to make changes or alterations or additions to the
Project or any portion thereof. Subject to the rights of Tenant specified in this Lease as to the non-exclusive use of certain portions of the Common Areas, Landlord shall have the sole and exclusive right to possession and control of the Common
Areas and all other areas of the Project outside the Leased Premises. 
  
 (b) At the written request of Tenant, if Landlord consents to a proposed item of Roof Top Equipment in accordance with Section 2.02(a) above, such consent shall include Landlord’s written determination whether or not such proposed Roof
Top Equipment shall be required to be removed at the expiration or termination of the Term. If Landlord so advises Tenant that a particular item of Roof Top Equipment must be removed, then Tenant shall remove the same and repair any resulting damage
to the Building upon the expiration or sooner termination of the Term. If Tenant installs an item of Roof Top Equipment without the consent of Landlord, or if Landlord otherwise fails to so advise Tenant in writing regarding whether or not a
proposed item of Roof Top Equipment must be removed at the expiration or termination of this Lease, then Tenant shall be required to remove such Roof Top Equipment upon such expiration or termination date. Nothing contained in this Section 2.02(b)
shall be deemed or construed to give Tenant the right to install any item of Roof Top Equipment without the written consent of Landlord as otherwise required under Section 2.02(a) above. 
  
 ARTICLE 3 
  
 Rent, Term, Use and Building Operating Costs 
  
 3.01 Term. Except as otherwise provided herein, the Term shall commence upon the Scheduled Term Commencement Date and shall continue in full
force for the Term. Should the Term Commencement Date be a date other than the Scheduled Term Commencement Date, either Landlord or Tenant, at the request of the other, shall promptly execute a Lease Commencement Certificate, a sample form of which
is attached hereto as Exhibit C, specifying the Term Commencement Date. Tenant’s obligation to pay Rent and its other obligations under this Lease shall commence upon the Term Commencement Date (except as expressly otherwise
provided herein with respect to obligations arising earlier). Upon execution of this Lease by Landlord and Tenant and the satisfaction of Landlord’s customary premises delivery conditions (such as the delivery of the Letter of Credit and the
providing of certificates of insurance by Tenant), Landlord shall deliver possession of the Leased Premises to Tenant. The date on which Landlord actually delivers possession of the Leased Premises to Tenant shall be herein referred to as the
“Delivery Date.” Any occupancy of the Leased Premises by Tenant prior to the Term Commencement Date shall be subject to the terms and conditions of this Lease except for the obligation to pay Gross Rent. Notwithstanding the
foregoing, the Term Commencement Date shall be delayed by one (1) day for each day the construction of the Tenant Improvements is actually delayed beyond the Scheduled Term Commencement Date due to either (i) a Landlord Delay or (ii) a Force Majeure
Event. 
  
 3.02 Use. Tenant shall use the Leased
Premises solely for the Permitted Use and for no other use or purpose. 
  

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 3.03 Payment of Base Rent and Estimated Building Operating Cost. Base Rent shall be payable
in advance on or before the first day of each calendar month during the Term and any extensions or renewals thereof; provided, however, that Base Rent in the amount of Thirty Thousand Dollars ($30,000.00) for the first full calendar month following
the Term Commencement Date shall be paid in advance immediately upon execution of this Lease. Estimated Building Operating Cost shall be payable in advance on or before the first day of each calendar month during the Term and any extensions or
renewals thereof. If the Term commences on other than the first day of a calendar month, then Gross Rent (consisting of Base Rent plus Estimated Building Operating Cost) provided for such partial calendar month shall be prorated and the prorated
amount shall be paid on the first day of the calendar month following the Term Commencement Date together with any other amounts payable on that day. If the Term terminates on other than the last day of a calendar month, then Gross Rent provided for
such partial calendar month shall be prorated and the prorated installment shall be paid on the first day of the calendar month preceding the Term Expiration Date. All payments due under this paragraph shall be payable in advance, without demand and
without reduction, abatement, counterclaim or setoff, at the address specified on the Basic Lease Information or at such other address as may be designated by Landlord in the manner provided for giving notice under Section 7.17 hereof. 

 
 3.04 Net Lease. This is a Net Lease. Base Rent shall be paid
to Landlord absolutely net of all costs and expenses. The provisions for payment of Building Operating Cost by means of periodic payment of Estimated Building Operating Cost and the Building Operating Cost Adjustment are intended to pass on to
Tenant and reimburse Landlord for all costs and expenses of the nature described in Section 3.05. 
  

	 	3.05	Project Operating Cost. 

  
 (a) Project Operating Cost shall mean all commercially reasonable expenses and costs (but not specific costs that are separately billed to and paid by
specific tenants) of every kind and nature that Landlord shall pay or incur or become obligated to pay or incur (including, without limitation, costs incurred by managers and agents that are reimbursed by Landlord) because of or in connection with
the management, maintenance, preservation, ownership and operation of the Project and its supporting facilities directly servicing the Project (collectively, the “Project Ownership”) (as allocated to the Project in accordance with
generally accepted accounting principles, consistently applied (“GAAP”)) including, but not limited to, the following: 
  
 (i) Wages, salaries (excluding executives’ salaries which, in the organization of the named Landlord hereunder, shall mean individuals at or above
the level of vice president) and reimbursable expenses and benefits of all on-site and off-site personnel engaged in the operation, maintenance and security of the Project and the direct costs of training such employees limiting such charges only to
amounts directly allocable to services rendered by the employees and personnel for the benefit of the Project. 
  
 (ii) Costs of the property management office and office operation. 
  

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 (iii) All supplies, materials and rental equipment used in the operation and maintenance of the Project.

  
 (iv) Utilities, including, without limitation, water, power,
sewer, waste disposal, communication facilities, heating, cooling, lighting and ventilation serving the Common Areas. 
  
 (v) All maintenance, janitorial and service agreements for the Project and the equipment therein, including, but not limited to, alarm service, window
cleaning, elevator maintenance, maintenance and repair of sidewalks, storm water pollution prevention, landscaping, building exteriors and service areas, but specifically excluding any janitorial services for the Leased Premises (which shall be
separately arranged and paid for by Tenant). 
  
 (vi) A management
cost recovery equal to three percent (3%) of all revenue (excluding such management cost recovery) derived from the Project, without limitation, all Rent hereunder, all rent and other payments derived from other tenants in the Building, parking
revenues and other revenues derived from licensees of any other part of or right in the Building. 
  
 (vii) Legal and accounting services for the Project, including, but not limited to, the costs of audits by certified public accountants of Project
Operating Cost records; provided, however, that legal expense shall not include the cost of (A) negotiating lease terms for prospective tenants, (B) negotiating termination or extension of leases with existing tenants, (C) proceedings against any
other specific tenant relating solely to the collection of rent or other sums due to Landlord from such tenant, (D) legal costs incurred in connection with development and/or construction of the Project, or (E) legal and other costs associated with
the defense of Landlord against suits, civil or criminal, arising out of the ownership or management of the Project but unrelated to Tenant. 
  
 (viii) All insurance premiums and costs, including, but not limited to, the premiums and cost of fire, casualty, liability, rental abatement and
earthquake insurance applicable to the Project and Landlord’s personal property used in connection therewith (and all amounts paid as a result of loss sustained that would be covered by such policies but for “deductible” or
self-insurance provisions); provided, however, that Landlord may, but shall not be obligated to, carry earthquake insurance. 
  
 (ix) Repairs, replacements and general maintenance (except for repairs and replacements (A) paid for from the proceeds of insurance, (B) paid for directly
by Tenant, other tenants or any third party, or (C) for the benefit solely of tenants of the Project other than Tenant to the extent that Tenant could not obtain similar services from Landlord without an obligation to reimburse Landlord for the
entire cost thereof under the provisions of this Lease). 
  
 (x)
All real estate or personal property taxes, possessory interest taxes, business or license taxes or fees, service payments in lieu of such taxes or fees, annual or periodic license or use fees, including, but not limited to, all of the following:
(A) all real estate taxes and assessments, and all other taxes relating to, or levied, assessed or imposed on, the Project, or any portion thereof, or interest therein; (B) all taxes, assessments, charges, levies, fees, excises or penalties, general
and special, ordinary and extraordinary, unforeseen as well as 
  

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 foreseen, of any kind and nature imposed, levied upon, measured by or attributable to Landlord’s equipment,
furniture, fixtures and other property located in, or used in connection with, the Project, or levied upon, measured by or reasonably attributable to the cost or value of any of the foregoing; (C) all other taxes (including, without limitation,
value added taxes), assessments, charges, levies, fees, or penalties, general and special, ordinary and extraordinary, unforeseen as well as foreseen, of any kind and nature imposed, levied, assessed, charged or collected by any governmental
authority or other entity either directly or indirectly (1) for or in connection with public improvements, user, maintenance or development fees, transit, parking, housing, employment, police, fire, open space, streets, sidewalks, Utilities, job
training, child care or other governmental services or benefits, (2) upon or with respect to the development, possession, leasing, operation, management, maintenance, alteration, repair, use or occupancy of, or business operations in, the Project,
(3) upon, against or measured by the area of the Project, or uses made thereof, or leases made to tenants thereof, or all or any part of the rents collected or collectible from tenants thereof, and (4) for environmental matters or as a result of the
imposition of mitigation measures, including parking taxes, employer parking regulations, or fees, charges or assessments as a result of the treatment of the Project, or any portion thereof or interest therein, as a source of pollution or storm
water runoff; (D) any tax or excise, however described, imposed in addition to, or in substitution partially or totally of, any or all of the foregoing taxes, assessments, charges or fees; and (E) any and all costs, expenses and attorneys’ fees
paid or incurred by Landlord in connection with any proceeding or action to contest in whole or in part, formally or informally, the imposition, collection or validity of any of the foregoing taxes, assessments, charges or fees. If by Law (as
defined in Section 5.10(a) below) any Real Property Taxes may be paid in installments at the option of the taxpayer, then Landlord shall include within Real Property Taxes only those installments (including interest, if any) which would become due
by exercise of such option. Real estate taxes shall not include (x) inheritance or estate taxes imposed upon or assessed against the Project, or any part thereof or interest therein, or (y) taxes computed upon the basis of the net income derived
from the Project by Landlord or the owner of any interest therein. In addition, notwithstanding the foregoing terms of this Section 3.05(a)(x), Tenant shall only be responsible for penalties attributable to Tenant’s late payment of Rent to
Landlord. 
  
 (xi) Amortization (together with reasonable
financing charges) of capital improvements made to the Project (A) to comply with the requirements of Laws, (B) to replace items which Landlord would be obligated to maintain under this Lease, or (C) to improve the operating efficiency of the
Project; provided, however, that in the case of improvements made solely for efficiency purposes, the amount chargeable as a Project Operating Cost in any year shall not exceed Landlord’s reasonable determination of the efficiency achieved
either in direct cost savings, avoidance of cost increases or a combination of both. As used in this Section 3.05(a)(xi), “amortization” shall mean allocation of the cost equally to each year of useful life of the items being
amortized or a shorter period equal to the number of years required to recover the cost of said item of capital improvement out of the savings in operating efficiency derived therefrom. Notwithstanding the foregoing, however, Landlord may treat as
expenses (chargeable in the year incurred) and not as capital costs items that are less than Thirty Thousand Dollars ($30,000.00) in cost (or, if the same is attributable solely to the Building, Fifteen Thousand Dollars ($15,000.00)); provided,
however, that the foregoing sums (i.e., $30,000.00 and $15,000.00) shall be increased on the first anniversary of the Commencement Date (the “Initial Adjustment Date”) to an amount equal to the product of $30,000.00 or
$15,000.00, as 
  

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 applicable, multiplied by a fraction, the numerator of which is the CPI Index for the most recently published month prior
to the Initial Adjustment Date, and the denominator of which is the CPI Index for the most recently published month prior to the Commencement Date. Thereafter, on each subsequent twelve (12) month anniversary of the Initial Adjustment Date (each
such date referred to herein as an “Adjustment Date”), each such sum shall be increased to an amount equal to the product of the amount in effect during the previous twelve (12) month period multiplied by a fraction, the numerator
of which is the CPI Index for the most recently published month prior to the Adjustment Date, and the denominator of which is the CPI Index for the most recently published month prior to the previous Adjustment Date. Notwithstanding the foregoing,
in no event shall at any time such sums be less than the applicable amounts in effect during the immediately preceding twelve (12) month period. As used herein, “CPI Index” means the percentage increase in the Consumer Price Index
published by the Bureau of Labor Statistics (“BLS”) for the San Francisco Bay Area, All Urban Consumers, All Items, (1982-84=100) (“CPI”) or any other renamed local index covering the San Francisco metropolitan
area. If the BLS changes the base reference for the CPI Index from 1982-84 = 100, and ceases to publish the CPI Index with such base reference, the adjustment shall be determined with the use of such usual conversion formula or table as may be
published by the BLS. If the BLS otherwise substantially revises, or ceases publication of the CPI Index, then a substitute index for determining cost of living adjustments used by the BLS or other reliable governmental or non-partisan publication
shall be reasonably designated by Landlord. 
  
 The Project
Operating Cost incurred by Landlord in any calendar year shall be deemed to be “commercially reasonable” so long as such Project Operating Cost, taken as a whole (as reflected in the Reconciliation Statement for such year) does not exceed
the aggregate costs and expenses that would generally be incurred by an Institutional Owner (as hereinafter defined) during such year in connection with the Project Ownership, applying Institutional Asset Management Practices (as hereinafter
defined). As used herein, the term “Institutional Owner” means pension funds, life insurance companies, real estate investment trusts and other institutional owners and operators of commercial real estate in the San Francisco Bay
Area, and “Institutional Asset Management Practices” means the asset management standards generally employed by Institutional Owners with respect to real estate assets held for purposes of investment (as opposed to owner-occupied
assets). 
  
 (b) Notwithstanding any other provision herein to the
contrary, if the Project is not fully occupied during any period of the Term in which Tenant is not leasing the entire Building from Landlord (including, without limitation, during the Initial Period when Tenant shall be leasing less than the entire
Building in accordance with Section 2.01(b) above and any other period when Tenant is not leasing the entire Building, whether pursuant to a consensual modification of this Lease, the recapture by Landlord of a portion of the Leased Premises
pursuant to Section 5.07(b) below, or otherwise), an adjustment shall be made in computing the components of Project Operating Cost that vary by occupancy for such year so that Project Operating Cost shall be computed as though the Project had been
fully occupied during such year; provided, however, that in no event shall Landlord collect in total, from Tenant and all other tenants of the Project, an amount greater than one hundred percent (100%) of the actual Project Operating Cost during any
year of the Term. 
  

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 (c) Notwithstanding anything to the contrary in this Lease, Building Operating Cost shall not include and
Tenant shall not have any obligation to pay for the following (collectively, “Costs”): 
  
 (i) Costs occasioned by the violation of any Law by Landlord, any other occupant of the Project, or their respective agents, employees or contractors;

  
 (ii) Costs occasioned by casualty or by the exercise of the
power of eminent domain; 
  
 (iii) Costs of any repairs to or
replacements of the structural components of the Building, the foundations, footings, floor slab and load bearing walls; 
  
 (iv) Costs of any renovation, improvement, painting or redecorating of any portion of the Project not made available for Tenant’s use, excluding only
Common Areas; 
  
 (v) increases in insurance Costs caused by the
activities of another occupant of the Project; 
  
 (vi) insurance
deductibles, co-insurance payments and other costs of casualty to the extent Tenant’s share thereof exceeds One Hundred Thousand Dollars ($100,000.00) (or, in the case of an earthquake, Four Hundred Thousand Dollars ($400,000.00)) for any
single event; 
  
 (vii) earthquake insurance premiums to the
extent they exceed eight (8) times standard “special causes of loss” insurance premiums; provided, however, that in the event (A) the Building shall hereafter be owned by a party other than Landlord or a Landlord Affiliate, or (B)
Landlord’s constituent member should hereafter change and if, as a result thereof, Landlord is no longer able to obtain earthquake insurance at premiums that are materially lower than the premiums generally available to owners of properties
similar to and in the vicinity of the Project, then in either case, earthquake insurance premiums shall be excluded to the extent that they exceed five (5) (as opposed to eight (8)) times standard “special causes of loss” insurance
premiums; 
  
 (viii) Costs incurred in connection with the
presence of any Hazardous Materials on or about the Project; provided, however, that the foregoing shall not be deemed to limit or affect Tenant’s obligations under Section 5.18 below; 
  
 (ix) depreciation, amortization or other expense reserves; 
  
 (x) interest, charges and fees incurred on mortgage indebtedness encumbering
the Project; and 
  
 (xi) Costs of capital improvements made to
the Project, except as amortized as set forth above. 
  
 Notwithstanding the terms of the foregoing subsection (vi), if Landlord is compelled to recognize a deductible under a policy of earthquake insurance (meaning that Landlord incurs an 
  

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 actual loss that is not covered by insurance due to such deductible), or if Landlord makes a coinsurance payment or
suffers other costs resulting from an earthquake, then Landlord shall amortize such deductible, coinsurance payment and other costs for purposes of this Section 3.05 such that Tenant shall reimburse Landlord for Tenant’s share of the same, up
to One Hundred Thousand Dollars ($100,000.00) per calendar year (commencing in the year in which the casualty occurs), until Tenant has fully reimbursed Landlord for Tenant’s share of the same (subject to the cap of Four Hundred Thousand
Dollars ($400,000.00) imposed under clause (vi) above), with such amortization continuing into the Renewal Terms, if any, if Tenant has not fully reimbursed Landlord for Tenant’s share of such deductible, coinsurance payment and other costs
(subject to the foregoing cap) by the expiration of the initial Term. 
  
 3.06 Allocation of Building Operating Cost. The parties acknowledge that the Building is a part of a multi-building project (i.e., the Project) and that the costs and expenses incurred in connection with the Project
(i.e., the Project Operating Cost) should be shared between Tenant as the tenant of the Building and the tenants of the other buildings in the Project, including, without limitation, the expenses and costs associated with the management,
maintenance, preservation, ownership and operation of the Common Areas, presently or hereafter existing at the Project, that are, from time to time, allocated by Landlord, in its sole but reasonable discretion, between the Building and other
buildings, presently or hereafter existing at the Project. Accordingly, as set forth in Section 3.05 above, the Project Operating Cost shall be determined annually for the Project as a whole, and a portion of the Project Operating Cost, which
portion shall be reasonably determined by Landlord on an equitable basis, shall be allocated to Tenant as the tenant of the Building (as opposed to the tenants of any other buildings in the Project) and such portion shall be the Building Operating
Cost for purposes of this Lease. Such portion of the Project Operating Cost allocated to Tenant as the tenant of the Building shall include all Project Operating Costs attributable solely to the Building and an equitable portion of the Project
Operating Costs attributable to the Project as a whole based on the percentage equal to the number of rentable square feet included in the Leased Premises divided by the number of rentable square feet in the Project; provided, however, that (i)
Landlord may equitably adjust Tenant’s share of all or part of any item of expense or cost reimbursable by Tenant that relates to a repair, replacement, or service that benefits only the Leased Premises or the Building or only a portion of the
Project or, subject to Section 3.05(b) above, that varies with the occupancy of the Project; and (ii) the portion of the Project Operating Cost allocated to Tenant as the tenant of the Building shall exclude Project Operating Costs attributable
solely to other buildings in the Project. Tenant’s proportionate share of the Project is 23.98%. Tenant agrees to pay, as Additional Rent, such Building Operating Cost as so allocated by Landlord. 
  
 3.07 Adjustment For Variation Between Estimated and Actual. If
the Building Operating Cost Adjustment for any calendar year is a positive number (i.e., actual cost exceeds estimated cost) Tenant shall pay to Landlord, pursuant to Landlord’s billing therefor (submitted pursuant to Section 3.08), the
Building Operating Cost Adjustment within thirty (30) days after presentation of Landlord’s Reconciliation Statement (as hereinafter defined). If the Building Operating Cost Adjustment for any calendar year is a negative number (i.e.,
estimated cost exceeds actual cost), then Landlord at Landlord’s option shall pay the Building Operating Cost Adjustment to Tenant in cash, within ten (10) days after the Building Operating Cost Adjustment is finally determined, or credit said
amount against future installments of Rent payable by Tenant hereunder. Should the Term commence or terminate at any time other than the first day of a calendar year, the Building Operating Cost Adjustment shall be prorated for the exact number of
calendar days during such calendar year that fall within the Term. 
  

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 3.08 Computation of Building Operating Cost Adjustment. Landlord shall, within a reasonable
period of time after the end of any calendar year for which Estimated Building Operating Cost differs from Building Operating Cost, give written notice thereof to Tenant (the “Reconciliation Statement”). The Reconciliation Statement
shall contain or be accompanied by a statement of the Building Operating Cost during such calendar year (prepared by a certified public accountant), and a computation of Building Operating Cost Adjustment. Landlord’s failure to give such notice
and statement within a reasonable period of time after the end of any calendar year for which a Building Operating Cost Adjustment is due shall not release either party from the obligation to make the adjustment provided for in Section 3.07.

  

	 	3.09	Tenant’s Audit Right. 

  
 (a) Provided that an Event of Default is not then occurring under this Lease (nor is any event occurring which, with the passage of time or the giving of
notice, or both, would constitute an Event of Default hereunder), Tenant shall have the right, within ninety (90) days after the delivery of the relevant Reconciliation Statement, to review and audit Landlord’s books and records regarding such
Reconciliation Statement for the sole purpose of determining the accuracy thereof. Such review or audit shall be performed by or a nationally-recognized certified public accounting firm who shall calculate its fees with respect to hours actually
worked (as opposed to a calculation based upon percentage of recoveries or other incentive arrangement) and without any discount on time or rate. Such review or audit shall take place during normal business hours in the office of Landlord or
Landlord’s property manager in the San Francisco Bay Area and shall be completed within fourteen (14) days after the commencement thereof. If Tenant does not so review or audit Landlord’s books and records, Landlord’s Reconciliation
Statement shall be final and binding upon Tenant. In the event that Tenant determines on the basis of its review of Landlord’s books and records that the amount of Building Operating Cost paid by Tenant for the period covered by such
Reconciliation Statement is less than or greater than the actual amount properly payable by Tenant under the terms of this Lease, Tenant shall promptly pay any deficiency to Landlord or, if Landlord concurs with the results of such audit in its
reasonable discretion, Landlord shall promptly refund any excess payment to Tenant, as the case may be. If Landlord fails to concur with the results of Tenant’s audit, then within ten (10) business days after Landlord notifies Tenant of
Landlord’s disagreement with the audit results, Landlord and Tenant shall meet and shall attempt in good faith to resolve such disagreement. Each party shall make its accounting personnel available during such meeting and, to the extent
available, shall bring appropriate backup documentation to such meeting to support its position. If, following such meeting, the parties still fail to agree on the calculation of Building Operating Cost payable by Tenant for the applicable period,
then such dispute shall be resolved by arbitration in accordance with Section 3.09(b) below. Tenant shall be solely responsible for the costs and expenses of the audit, except that if such audit determines that the actual amount of Project Operating
Cost paid by Tenant during any calendar year exceeds the amount properly payable by Tenant hereunder during such period by an amount greater than six percent (6%) of the actual Project Operating Cost properly chargeable to Tenant during such period,
then Landlord shall reimburse Tenant (in the form of a credit against the Gross Rent next coming due hereunder or, if the Term has previously expired, in the form of a direct payment) for the 
  

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 reasonable costs of such audit. For purposes of determining whether the actual amount of Project Operating Cost paid by
Tenant during a calendar year exceeds the amount properly payable by Tenant hereunder by more than six percent (6%), the parties shall take into account amounts improperly included by Landlord in the calculation of Project Operating Cost, but shall
exclude any amount attributable to a disagreement over or an improper determination of an amortization period established by Landlord pursuant to Section 3.05(a)(xi) above. By way of example only, the parties shall take into account an amount
charged to Tenant but specifically excluded under the list of exclusions contained in Section 3.05(c) above, but shall disregard any excess amount included improperly but in good faith within Project Operating Cost attributable to Landlord’s
utilization of an incorrect amortization period for capital expenses. 
  
 (b) (i) If either party demands arbitration pursuant to Section 3.09(a), the notice of demand shall specify with (A) with particularity the demanding party’s proposed resolution of the matter in issue, and (B) the name and address of
the person designated by the demanding party to act as arbitrator on its behalf. Within ten (10) business days after such demand, the responding party shall give notice (the “Response”) to the demanding party specifying (1) with
particularity the responding party’s proposed resolution of the matter in issue, and (2) the name and address of the person designated by the responding party to act as arbitrator on its behalf. If the responding party fails to deliver a
Response within such ten (10) business day period, then the arbitrator appointed by the demanding party shall be the arbitrator to determine the issue. The arbitrators selected pursuant to this Section 3.09(b)(i) shall be certified public
accountants from national or major regional accounting firms who have not previously performed work for Landlord or Tenant and with at least ten (10) years experience in matters pertaining to the operation of office and research and development
properties similar to and in the vicinity of the Project. 
  
 (ii)
The arbitration shall be conducted in San Francisco, California in accordance with the Commercial Arbitration Rules of the American Arbitration Association. The judgment or the award rendered in any such arbitration may be entered in any court
having jurisdiction and shall be final and binding between the parties. Failure on the part of either party to make a timely and proper demand for arbitration shall constitute a waiver of the party’s right thereto, but not a waiver of such
party’s right to pursue any other legal or equitable remedies (provided that the other party does not timely and properly demand arbitration as herein provided). 
  
 (iii) If two (2) arbitrators are designated in accordance with Section 3.09(b)(i) above, such arbitrators shall meet within
ten (10) business days after the second arbitrator is appointed, and if, within ten (10) business days after such first meeting the two arbitrators shall be unable to agree promptly upon a determination of the matter in issue, they shall appoint a
third arbitrator, who shall be a competent and impartial person with qualifications similar to those required of the first two arbitrators under Section 3.09(b)(i) above. If they are unable to agree upon such appointment within five (5) business
days after expiration of such ten (10) business day period, the third arbitrator shall be selected by the parties themselves, if they can agree thereon, within a further period of ten (10) business days. If the parties cannot so agree, then either
party, on behalf of both, may request appointment of such a qualified person by the then Chief Judge of the United States District Court having jurisdiction over the City and County of San Francisco, acting in his private non-judicial capacity.
Request for appointment shall be 
  

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 made in writing with a copy given to the other party. Each party agrees that said judge shall have the power to make the
appointment. The three (3) arbitrators shall decide the dispute, if it has not previously been resolved, by following the procedure set forth below: 
  
 (A) The three (3) arbitrators shall attempt to decide the issue within fifteen (15) business days after the appointment of the third arbitrator. Within
such fifteen (15) business day period the arbitrators shall hold a hearing in accordance with the aforesaid rules at which each party may submit evidence, be heard and cross-examine witnesses, with each party having at least ten (10) business
days’ advance notice of the hearing. The hearing shall be conducted so that each of Landlord and Tenant shall have reasonably adequate time to present oral evidence or argument, but either party may present whatever written evidence it deems
appropriate prior to the hearing (with copies of any such written evidence being sent to the other party prior to the hearing). The arbitrators shall have the right to consult experts and competent authorities with factual information or evidence
pertaining to the determination of the matter at issue, but any such consultation shall be made in the presence of both parties with full right on their part to cross-examine. The decision in which any two (2) arbitrators so appointed and acting
hereunder concur shall be the final decision of the arbitration and the arbitrators shall render the decision and award in writing with counterpart copies to each party. The arbitrators shall have no power to modify the provisions of this Lease. Any
decision derived from the foregoing arbitration process shall be binding and conclusive upon the parties. If the arbitrators are unable to render a decision in accordance with the foregoing, or if the decision of the arbitrators shall be held by a
court of competent jurisdiction to be unenforceable for any reason, then the matter submitted to arbitration shall be subject to litigation in the courts of the State of California, and Landlord and Tenant each hereby waive its right to a jury trial
in any such court proceeding. 
  
 (B) If any arbitrator fails,
refuses or is unable to act, his successor shall be appointed by the party who appointed him, but in the case of the third arbitrator, his successor shall be appointed in the same manner as provided for appointment of the third arbitrator.

  
 (iv) Each party shall pay the fees and expenses of the
arbitrator designated by it, and fifty percent (50%) of the fees and expenses of the third arbitrator, if any. 
  
 ARTICLE 4 
  
 Landlord Covenants 
  
 4.01
Landlord’s Repair and Maintenance. Landlord agrees to repair and maintain, at its sole cost and expense, the structural portions of the Building. In addition, subject to Tenant’s obligations under Section 3.03 above, Landlord
agrees to repair and maintain (i) the elevators in the Building, (ii) the exterior wall of the Building, including glass and glazing, (iii) the roof, and (iv) the Common Areas. Landlord’s obligation hereunder to repair and maintain is subject
to the condition precedent that Landlord shall have received written notice (or shall otherwise have actual knowledge) of the need for such repairs and maintenance and a reasonable time to perform such repair and maintenance. Tenant shall promptly
report to Landlord any defective condition known to it which Landlord is required to repair. Landlord 
  

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 shall promptly report to Tenant in writing the estimated date upon which required Landlord repairs will commence and the
estimated time to completion of the required Landlord repair along with information regarding the vendor to be used. 
  
 4.02 Landlord’s Right to Perform. Without limiting any other rights or remedies of Landlord hereunder or at law, in the event that
Tenant fails or refuses to perform in a timely and efficient manner any of Tenant’s obligations hereunder, Landlord shall have the right, but not the obligation, to perform such obligations for Tenant’s account, including, without
limitation, the right to perform any repair, maintenance or replacement required to be performed by Tenant under Section 5.05 below, and the right to pay any amounts due to the providers of any Utilities pursuant to Section 5.03 below. Except in the
case of an emergency, Landlord shall provide no less than five (5) business days’ prior written notice of its intention to perform Tenant’s obligations. Except in the case of an emergency, Landlord shall refrain from performing
Tenant’s obligations hereunder if, during such five (5) business day period, Tenant performs the required obligations (or, if such obligations cannot reasonably be fully performed during such period, commences the performance of such
obligations during such period and thereafter diligently prosecutes the same to completion). All costs incurred by Landlord in performing any such obligations for the account of Tenant shall be repaid by Tenant to Landlord upon demand, together with
an administration fee equal to ten percent (10%) of such costs. 
  
 4.03 Exculpation. Landlord shall not be liable for damages to either person or property, nor shall Landlord be deemed to have evicted Tenant, nor shall there be any abatement of Rent, nor shall Tenant be relieved from
performance of any covenant on its part to be performed hereunder by reason of (i) deficiency in the performance of Landlord’s obligations under Section 4.01 above, or (ii) breakdown or malfunction of lines, cables, wires, pipes, equipment or
machinery utilized in supplying or permitting Utilities or telecommunications. Notwithstanding the foregoing, Landlord shall be liable for actual damages to person or property directly resulting from a deficiency in the performance of
Landlord’s obligations under Section 4.01 above, provided that (A) such deficiency persists for an unreasonable period of time following receipt by Landlord of written notice of default from Tenant, (B) such damages are not covered by any
policy of insurance actually carried by Tenant or required to be carried by Tenant under the terms of this Lease, and (C) in no event shall Landlord be liable for consequential damages. In no event shall any mortgagee or the beneficiary under any
deed of trust referred to in Section 5.13 be or become liable for any default of Landlord under Section 4.01 above (except that any such mortgagee or beneficiary shall cure any continuing defaults with respect to the physical condition of the Leased
Premises in accordance with Section 5.13(b) below). 
  
 4.04
Graphics and Signage. Tenant shall have the right to install, at its sole cost and expense, exterior identification signage on the Building (the “Identification Signage”), provided that Landlord shall have the right to
approve the size, style, design and location of such Identification Signage; and provided, further, that the Identification Signage shall be installed in accordance with all applicable Laws, including, without limitation, all requirements of the
City of Redwood City. Tenant shall also have the right to install, at its sole cost and expense, identification signage in the main lobby of Building and on the sign or signs existing on the grounds of the Project which identify the specific tenants
of the Building. All signs, notices and graphics of every kind or character, visible in or from the Common Area or the exterior of the Leased Premises shall be subject to Landlord’s prior written approval, which approval shall not 

 

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 be unreasonably withheld, provided that the requested signs, notices and/or graphics, as appropriate, are consistent with
a high quality office project. Upon the expiration or sooner termination of the Term of this Lease, Tenant shall, at its sole cost and expense, remove all signs, including, without limitation, the Identification Signage, from the Building and the
Project and repair any damage resulting from such removal. 
  
 4.05 Peaceful Enjoyment. Tenant shall peacefully have, hold and enjoy the Leased Premises, subject to the other terms hereof, provided that Tenant pays the Rent and performs all of Tenant’s covenants and agreements herein
contained. This covenant and the other covenants of Landlord contained in this Lease shall be binding upon Landlord and its successors only with respect to breaches occurring during its and their respective ownership of Landlord’s interest
hereunder. 
  
 ARTICLE 5 
  
 Tenant’s Covenants 
  
 5.01 Payments By Tenant. Tenant shall pay Rent at the times and
in the manner herein provided. All obligations of Tenant hereunder to make payments to Landlord shall constitute Rent and failure to pay the same when due, after written notice to Tenant thereof and the expiration of the applicable cure period set
forth in Section 7.08(a) below, shall give rise to the rights and remedies provided for in Section 7.08. 
  
 5.02 Construction of Tenant Improvements. Tenant shall cause the Contractor (as defined on Exhibit D hereto) to install Tenant
Improvements in the Leased Premises pursuant to Exhibit D. All building permit and municipal inspection fees payable with respect to such work shall be paid by Tenant. All additions to or improvements of the Leased Premises actually
paid for by Tenant, including any Tenant Improvements (whether of Building Standard Improvements or Tenant Extra Improvements) actually paid for by Tenant and any Alterations, shall automatically (without the need for any additional documentation or
actions on the part of the parties hereto) be and become the property of Landlord upon the expiration or sooner termination of this Lease and shall be surrendered to Landlord upon termination of this Lease by lapse of time or otherwise, subject to
Tenant’s obligations to remove the same in accordance with Section 5.19 below. Although Tenant Improvements (including any Tenant Extra Improvements) become the property of Landlord upon the expiration or sooner termination of this Lease, they
are intended to be for the convenience of Tenant and are not intended to be a substitute for Rent or any part thereof. Notwithstanding the foregoing, Tenant shall be entitled to all depreciation, amortization and other tax benefits with respect to
Tenant’s Alterations and Tenant’s furniture, equipment, machinery, trade-fixtures, goods or supplies (“Tenant’s Personal Property”). Tenant shall have the right to remove Tenant’s Personal Property at any time
during the Term, provided that Tenant repairs all damage caused by such removal. Notwithstanding anything in this Lease to the contrary, any equipment, machinery, or other improvements of any nature whatsoever that are connected to or integrated
into the Building Systems shall not be deemed Tenant’s Personal Property for purposes of this Lease. 
  

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	 	5.03	Utilities. 

  
 (a) Tenant shall arrange and pay for the cost of all water, sewer use, sewer discharge fees and permit costs and sewer connection fees, gas, heat,
electricity, refuse pick-up, janitorial service, telephone and other telecommunications and all materials and services or other Utilities (collectively, “Utilities”) applicable to the Leased Premises and/or Tenant, together with all
taxes, assessments, charges and penalties added to or included within such cost. Without limiting the generality of the foregoing, Utilities shall include HVAC and server room air conditioning and ventilation. Tenant shall arrange to be separately
billed by the provider of such Utilities, provided that to the extent that any such costs, fees and taxes are not separately billed to Tenant, Tenant shall pay the amount thereof as invoiced to Tenant by Landlord, within ten (10) days after receipt
of an invoice therefor. Tenant acknowledges that the Leased Premises, the Building and/or the Project may become subject to the rationing of Utility services or restrictions on Utility use as required by a public utility company, governmental agency
or other similar entity having jurisdiction thereof. Tenant acknowledges and agrees that its tenancy and occupancy hereunder shall be subject to such rationing or restrictions as may be imposed upon Landlord, Tenant, the Leased Premises, the
Building and/or the Project, and Tenant shall in no event be excused or relieved from any covenant or obligation to be kept or performed by Tenant by reason of any such rationing or restrictions. Tenant agrees to comply with energy conservation
programs implemented by Landlord by reason of rationing, restrictions or Laws. 
  
 (b) Landlord shall not be liable for any loss, injury or damage to property caused by or resulting from any variation, interruption, or failure of Utilities due to any cause whatsoever, or from failure to make any
repairs or perform any maintenance required to be made or performed by Landlord hereunder, unless such failure has continued for an unreasonable period of time after Landlord has received written notice of the need for such repairs or maintenance.
No temporary interruption or failure of such services incident to the making of repairs, alterations, improvements, or due to accident, strike, or conditions or other events shall be deemed an eviction of Tenant or relieve Tenant from any of its
obligations hereunder. In no event shall Landlord be liable to Tenant for any damage to the Leased Premises or for any loss, damage or injury to any property therein or thereon occasioned by bursting, rupture, leakage or overflow of any plumbing or
other pipes (including, without limitation, water, steam, and/or refrigerant lines), sprinklers, tanks, drains, drinking fountains or washstands, or other similar cause in, above, upon or about the Leased Premises, the Building, or the Project.

  
 5.04 Taxes On Personal Property, Tenant Extra
Improvements and Alterations. In addition to, and wholly apart from its obligation to pay Building Operating Costs, Tenant shall be responsible for and shall pay prior to delinquency taxes or governmental service fees, possessory interest
taxes, fees or charges in lieu of any such taxes, capital levies, or other charges imposed upon, levied with respect to or assessed against its personal property, on the value of its Tenant Improvements and Alterations, on its interest pursuant to
this Lease or on any use made of the Leased Premises or the Common Areas by Tenant in accordance with this Lease. To the extent that any such taxes are not separately assessed or billed to Tenant, Tenant shall pay the amount thereof as invoiced to
Tenant by Landlord. 
  
 5.05 Repairs By Tenant.
Tenant shall, at all times and at Tenant’s sole cost and expense, maintain and repair the Leased Premises and keep the same in good order and 
  

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 condition. Tenant shall not do nor shall Tenant allow the Tenant Parties to do anything to cause any damage,
deterioration or unsightliness to the Leased Premises, the Building or the Project. Tenant’s obligations hereunder shall include, without limitation: (i) the obligation to maintain and repair and keep in good order and condition the Leased
Premises, and repair and replace every part thereof, including, without limitation, all walls, floors, ceilings, interior glass, windows, window frames and casements, interior doors and door frames and door closers, fixtures, interior lighting
(including, without limitation, light bulbs and ballasts), all mechanical, electrical, HVAC, plumbing, life safety and other systems serving the Leased Premises, all communications systems serving the Leased Premises, signage, equipment and interior
painting, whatever the scope of the work of maintenance or repair required (excepting only those portions of the Building or the Project to be maintained by Landlord, as provided in Section 4.01 above), (ii) the obligation to furnish all
expendables, including light bulbs, paper goods and soaps, used in the Leased Premises, and (iii) the obligation to repair all damage caused by Tenant or Tenant Parties to any portion of the Project, whatever the scope of the repair required. Tenant
shall repair all damage caused by removal of Tenant’s movable equipment or furniture or the removal of any Tenant Extra Improvements or Alterations permitted or required by Landlord, all as provided in Section 5.19. Any work of repair and
maintenance performed by or for the account of Tenant shall be performed by contractors reasonably approved by Landlord prior to commencement of the work and in accordance with procedures Landlord shall from time to time establish. Without limiting
the foregoing, Tenant will enter into preventive maintenance and service contracts with vendors that are approved by Landlord for regularly scheduled maintenance of all Building Systems serving the Leased Premises. All such work shall be performed
in compliance with all applicable Laws, and Tenant shall provide to Landlord copies of all permits and records of inspection issued or obtained by Tenant in connection therewith to establish such compliance. 
  
 5.06 Waste. Tenant shall not commit or allow any waste or
damage to be committed in any portion of the Leased Premises. 
  

	 	5.07	Assignment or Sublease. 

  
 (a) If Tenant intends to assign this Lease or sublet the Leased Premises or any part thereof, Tenant shall give Landlord written notice of such intent.
Tenant’s notice shall set forth the date any such assignment or sublease shall commence and be accompanied by an exact copy of the proposed agreements between Tenant and the proposed assignee or subtenant. Tenant shall provide Landlord with (i)
any additional information or documents reasonably requested by Landlord within five (5) business days after receiving Tenant’s notice, and (ii) an opportunity to meet and interview the proposed assignee or subtenant, if requested by Landlord.

  
 (b) Landlord shall then have a period of ten (10) days
following such interview and receipt of such additional information (or fifteen (15) days from the date of Tenant’s original notice if Landlord does not request additional information or an interview) within which to notify Tenant in writing
that Landlord elects either (A) to terminate this Lease as to the space so affected as of the date so specified by Tenant in its notice under Section 5.07(a) above, in which event Tenant will be relieved of all further obligations hereunder as to
such space, or (B) to permit Tenant to assign this Lease or sublet such space, subject, however, to prior written approval of the proposed assignee or sublessee by Landlord. In the event Landlord fails to 
  

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 respond to Tenant within such ten (10) or fifteen (15) day period, as applicable, then Tenant shall provide a second
written notice to Landlord requesting such response. The notice shall contain the words “FAILURE TO RESPOND WITHIN FIVE (5) BUSINESS DAYS
SHALL CAUSE YOU TO LOSE VALUABLE LEGAL RIGHTS” in 14-point bold print at the top thereof. If Landlord fails to respond to
Tenant within five (5) business days after Landlord’s receipt of such second notice, then Landlord shall be deemed to have elected to proceed under the foregoing clause (B) and to have approved the proposed assignment or sublease transaction
described in Tenant’s written notice. Notwithstanding anything herein to the contrary, Landlord shall have the right to terminate this Lease under the foregoing clause (A) only if the square footage of the premises covered by the proposed
sublease, when aggregated with the square footage of the premises covered under all other subleases then in effect, equals or exceeds thirty thousand (30,000) square feet. The approval by Landlord of the proposed assignee or sublessee shall not be
unreasonably withheld so long as: (i) the use of the Leased Premises by such proposed assignee or sublessee would be a Permitted Use; (ii) the proposed assignee or sublessee is of sound financial condition as determined by Landlord; (iii) the
proposed assignee’s or sublessee’s use will not involve the storage, use, treatment or disposal of any Hazardous Material (except for Permitted Hazardous Materials transported, stored and used in accordance with the provisions of this
Lease and other Hazardous Materials approved by Landlord in accordance with Section 5.18 below); (iv) the proposed use or the proposed assignee or sublessee would not cause the violation of any covenant or agreement of Landlord to any third party or
would permit any other tenant to terminate its lease (Landlord hereby agreeing that, if Tenant desires to enter into an assignment or sublease hereunder, Tenant shall have the right to request written notice from Landlord of all such covenants,
agreements and leases that could be terminated); and (v) if the proposed subtenant or assignee then leases or occupies any other space in the Project, Landlord shall not have entered into a letter of intent or executed term sheet with such party for
the lease of additional space in the Project. Failure by Landlord to approve a proposed subtenant or assignee shall not cause a termination of this Lease, and the sole remedy of Tenant shall be an action for injunctive or declaratory relief.

  
 (c) Notwithstanding the terms of Section 5.07(b) above, Tenant
shall have the right to assign this Lease or to sublease all or a portion of the Leased Premises to a Qualified Tenant Affiliate (as hereinafter defined) with twenty (20) days’ prior written notice to, but without the consent of, Landlord. As
used herein, “Qualified Tenant Affiliate” means any corporation or other legal entity which (i)(A) is a wholly owned subsidiary of Tenant, or (B) results from the merger or consolidation of Tenant with another entity, or (C)
acquires all or the majority of the outstanding shares in or all or substantially all of the assets of Tenant, and (ii) has a tangible net worth (tangible assets less total liabilities, and specifically excluding all intangible assets, such as
goodwill, patents, trademarks and other intellectual property, franchises, R&D expenditures, advertising expenditures, etc.), as determined in accordance with GAAP (“Tangible Net Worth”), equal to or greater than the Tangible
Net Worth of Tenant on the date of the proposed sublease or assignment. 
  
 (d) Any rent or other consideration realized by Tenant under any such sublease and assignment in excess of the Rent payable hereunder, after first deducting the applicable unamortized portion of (i) reasonable and customary market-based
leasing commissions, if any, paid by Tenant in connection with such sublease or assignment, (ii) reasonable attorneys’ fees, if any, paid by Tenant in connection with such sublease or assignment, and (iii) the cost actually 
  

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 paid by Tenant of Alterations made by Tenant to the Sublease Premises (as hereinafter defined) in connection with and as
necessary to complete the specific assignment or sublease transaction (but specifically excluding the Tenant Improvements and any prior Alterations made by Tenant to the Leased Premises), shall be divided and paid fifty percent (50%) to Landlord and
fifty percent (50%) to Tenant. For the purposes of the aforesaid calculation, any such commissions, fees and costs paid by Tenant in connection with such sublease or assignment, if any, shall be amortized on a straight-line basis over the term of
such sublease or assignment. As used herein, “Sublease Premises” shall mean, with respect to any assignment or sublease agreement, the portion of the Leased Premises that it covered by such agreement. 
  
 (e) No assignment or subletting by Tenant shall relieve Tenant of any
obligation under this Lease. Any assignment or subletting that conflicts with the provisions hereof shall be void. No consent by Landlord to any subletting or assignment shall constitute a consent to any other assignment or subletting nor shall it
constitute a waiver of any of the provisions of this Section 5.07 as they apply to any such future sublettings or assignments. 
  
 (f) Any assignee shall assume in writing, for the express benefit of Landlord, all of the obligations of Tenant under this Lease, provided that no such
assumption shall be deemed a novation or other release of the prior Tenant. Following any assignment, the obligations for which the prior Tenant remains liable under this Lease shall include, without limitation, any obligations arising in connection
with any amendments to this Lease executed by Landlord and the assignee, whether or not such amendments are made with knowledge or consent of the prior Tenant. 
  

(g) Tenant shall not market or otherwise offer space within the Leased Premises for sublease or assignment, nor shall Tenant enter into any subletting
or assignment of this Lease, until after the Term Commencement Date has occurred. 
  
 (h) Any improvements, additions, or alterations to the Building or the Project that are required by any Laws as a result of any subletting or assignment hereunder, shall be installed and provided without cost or
expense to Landlord. Landlord may condition its consent to any proposed sublessee or assignee on the construction of such improvements. 
  
 (i) Landlord may hire outside consultants to review all assignment and subletting documents and information. Tenant shall reimburse Landlord for the cost
thereof, including reasonable attorneys’ fees, on demand. 
  
 (j) Without liability to Tenant, Landlord shall have the right to offer and to lease space in the Building, or in any other property, to any party, including, without limitation, parties with whom Tenant is negotiating, or with whom Tenant
desires to negotiate, concerning assignment or subletting the Leased Premises, or any portion thereof. Notwithstanding the foregoing, Landlord shall not offer to lease space in the Project to any party who is identified in a notice given by Tenant
to Landlord pursuant to Section 5.07(a) above, provided that Tenant has actually entered into an executed term sheet or letter of intent, or an assignment or sublease agreement, with such party (with, in the case of an assignment or sublease
agreement, the effectiveness thereof being subject only to Landlord’s approval as required by Sections 5.07(a) and (b) above); provided, however, that Landlord shall have the right in all instances to offer to 
  

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 lease space in the Project to any such party if Landlord elects, pursuant to Section 5.07(a) above, to recapture the
portion of the Leased Premises that Tenant proposed to sublease to such party (or, in the case of an assignment, the entirety of the Leased Premises). 
  

	 	5.08	Alterations, Additions or Improvements. 

  
 (a) Tenant shall not make or allow to be made any alterations, additions or improvements in or to the Leased Premises (collectively,
“Alterations”) without obtaining the prior written consent of Landlord. Landlord’s consent shall not be unreasonably withheld with respect to proposed Alterations that (i) comply with all applicable Laws, (ii) are compatible
with the Building and the Building Systems, (iii) will not interfere with the use and occupancy of any portion of the Project by any other tenant or their invitees, (iv) do not affect the structural portions of the Building or the Project, and (v)
do not and will not, whether alone or taken together with other improvements, require the construction of any other improvements or alterations within the Building or the Project. Notwithstanding the foregoing, Tenant shall have the right to make
Alterations to the Leased Premises with prior notice to but without the consent of Landlord, provided that such Alterations (A) satisfy the criteria set forth in the foregoing clauses (i) through (v) and are constructed and performed in full
compliance with all Laws (as defined in Section 5.10(a) below) and the terms of Section 5.08(c) below (including, without limitation, the delivery of the documentation and information required under said Section 5.08(c), excluding plans and
specifications), (B) neither affect the structure of the Building nor interface and/or connect with the Building Systems, and (C) do not exceed Twenty-Five Thousand Dollars ($25,000.00) in cost individually or in the aggregate during any twelve (12)
consecutive month period of the Term (collectively, “Permitted Alterations”). 
  
 (b) In the event Landlord fails to respond to a request given by Tenant for approval of Alterations pursuant to Section 5.08(a) above within fifteen (15) days following Landlord’s receipt of such request and such
additional information as Landlord may require to consider Tenant’s request, then Tenant shall provide a second written notice to Landlord requesting such response. The notice shall contain the words “FAILURE
TO RESPOND WITHIN FIVE (5) BUSINESS DAYS SHALL CAUSE YOU TO LOSE
VALUABLE LEGAL RIGHTS” in 14-point bold print at the top thereof. If Landlord fails to respond to Tenant within five (5) business days after Landlord’s receipt of such second notice, then
Landlord shall be deemed to have approved the Alterations described in Tenant’s written notice. 
  
 (c) In determining whether or not to consent to proposed Alterations, Landlord shall have the right (without limitation) to review plans and
specifications for proposed Alterations, construction means and methods, the identity of any contractor or subcontractor to be employed on the work of Alterations, and the time for performance of such work. Tenant shall supply to Landlord any
documents and information requested by Landlord in connection with the exercise of its rights hereunder. Landlord may hire outside consultants to review such documents and information and Tenant shall reimburse Landlord for the reasonable cost
thereof, including reasonable attorneys’ fees, upon demand. All Alterations permitted hereunder shall be made and performed by Tenant, without cost or expense to Landlord. The obligations of the parties with respect to removal of Alterations
shall be controlled by Section 5.19. Without limiting the foregoing, before Alterations may begin, Tenant shall provide Landlord with copies of valid building permits or other permits or licenses required for the construction of such Alterations and

  

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 Tenant shall, at Tenant’s sole cost and expense, during the course of construction of any Alterations, maintain
builders’ risk insurance for the amount of the completed value of the Alterations on an all-risk non-reporting form covering all improvements under construction, including building materials, and such other insurance in amounts and against such
risks as Landlord shall reasonably require in connection with the Alterations, including, without limitation, naming Landlord and Mortgage Lender (as defined in Section 5.13 below) as loss payee under any such policy or policies. In addition to and
without limitation on the generality of the foregoing, Tenant shall ensure that its contractor(s) procure and maintain in full force and effect, during the course of construction of such Alterations, a “broad form” commercial general
liability and property damage policy of insurance naming Landlord, Tenant and Mortgage Lender as additional insureds. Such insurance shall have policy limits of no less than Two Million Dollars ($2,000,000.00) combined single limit for bodily injury
or property damage in any one accident or occurrence, and shall contain a severability of interest clause or a cross liability endorsement. 
  
 (d) (i) Subject to Section 5.08(d)(ii) below, at the written request of Tenant, if Landlord consents to a proposed Alteration, such consent shall include
Landlord’s written determination whether or not such proposed Alteration shall be required to be removed and the Leased Premises restored to the condition existing prior to the making of such Alteration at the expiration or termination of the
Term. If Tenant makes a Permitted Alteration to the Leased Premises without the consent of Landlord pursuant to Section 5.08(a) above, or if Landlord otherwise fails to so advise Tenant in writing regarding whether or not a proposed Alteration must
be removed and the Leased Premises so restored at the expiration or termination of this Lease, then Tenant shall be required to remove such Alteration and restore the Leased Premises upon such expiration or termination date. 
  
 (ii) In the event Tenant installs Tenant Improvements or Alterations in the
Leased Premises and, subsequent to such installation, desires to remove or relocate any of the same within the Leased Premises, then such removal or relocation shall itself constitute an “Alteration” and shall be governed by the terms of
Sections 5.08(a) through (d)(i) above, as modified by the following: 
  
 (A) Landlord shall not have the right under subsection (i) above to require Tenant to restore the Leased Premises (i.e., rebuild the Tenant Improvement or Alteration to its condition prior to the removal or relocation of the same),
except for, subject to subsection (B) below, Tenant Improvements which were funded (in whole or in part) by Landlord’s Contribution. 
  
 (B) Landlord shall have the right (by notice to Tenant in accordance with Section 5.08(d)(i) above) to require Tenant to restore any Tenant Improvements
that were funded (in whole or in part) by Landlord’s Contribution and that are subsequently removed or relocated by Tenant, except that any such restoration obligation on the part of Tenant shall be waived if Tenant exercises the Renewal Option
and pays all Rent reserved hereunder for the entirety of the Renewal Term. 
  
 5.09 Liens. Tenant shall keep the Leased Premises and the Project free from any liens arising out of any (i) work performed or material furnished to or for the Leased Premises, and 
  

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 (ii) obligations incurred by or for Tenant or any person claiming through or under Tenant. Tenant shall, within thirty
(30) days following the imposition of any such lien (or, if Landlord is then attempting to sell or refinance the Building or the Project, within ten (10) days following the imposition of any such lien), cause such lien to be released of record by
payment or posting of a bond fully satisfactory to Landlord in form and substance. Landlord shall have the right at all times to post and keep posted on the Leased Premises any notices permitted or required by Law, or that Landlord shall deem proper
for the protection of Landlord, the Leased Premises, the Project and any other party having an interest therein, from mechanics’, materialmen’s and other liens. If Tenant fails in its obligations to cause any such lien to be released of
record within said thirty (30) (or, if applicable, ten (10)) day period, Landlord may cause such liens to be released by any means it deems proper, including, without limitation, payment of any such lien, at Tenant’s sole cost and expense. All
costs and expenses incurred by Landlord in causing such liens to be released shall be repaid by Tenant to Landlord immediately upon demand, together with an administration fee equal to fifteen percent (15%) of such costs and expenses. In addition to
all other requirements contained in this Lease, Tenant shall give to Landlord at least five (5) business days’ prior written notice before commencement of any construction on the Leased Premises. 
  

	 	5.10	Compliance With Laws, Insurance Standards and Non-Discrimination. 

  
 (a) Tenant shall comply with all federal, state and local laws, ordinances, orders, rules, regulations and policies
(collectively, “Laws”), now or hereafter in force, as amended from time to time, in any way related to the use, condition or occupancy of the Leased Premises, regardless of when they become effective, including, without limitation,
all applicable Hazardous Materials Laws, the Americans with Disabilities Act of 1990, as amended; provided, however, that except as otherwise provided in this Lease, Tenant shall not be required to make or, except as provided in Article 3 above, pay
for, capital improvements to the Leased Premises or the Building not related to Tenant’s specific use of the Leased Premises unless the requirement for such changes is imposed as a result of any Alterations made or proposed to be made at
Tenant’s request. Tenant shall immediately deliver to Landlord a copy of any notices received from any governmental agency in connection with the Leased Premises. It is the intention of Tenant and Landlord that the obligations of Tenant under
this Section 5.10 shall apply irrespective of the scope of work required to achieve such compliance. Tenant shall promptly cure and satisfy all Hazardous Materials Claims to the extent arising out of or by reason of the use, storage, treatment,
disposal or release of Hazardous Materials by Tenant, its subtenants, or Tenant Parties or any employees, agents, contractors, officers, directors, partners, licensees, invitees and guests of Tenant’s subtenant. Nothing done by Tenant in its
use or occupancy of the Leased Premises shall create, require or cause imposition of any requirement by any governmental authority for structural or other upgrading of or improvement to the Project. Notwithstanding the foregoing, if such
governmental requirement would require upgrades only to the Building (as opposed to areas of the Project outside of the Building), then Tenant shall not be in default hereunder if its use or occupancy triggers such requirements, provided that (i)
Tenant performs such upgrades and pays all costs in connection therewith (unless Landlord elects to perform such upgrades, in which case Tenant shall reimburse Landlord for the costs thereof), and (ii) if structural upgrades would be required to be
made to the Building, Tenant shall obtain Landlord’s prior written consent prior to taking the action that triggers such requirements. 
  

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 (b) Tenant shall not occupy or use, or permit any portion of the Leased Premises to be occupied or used,
for any business or purpose that is disreputable or productive of fire hazard, or permit anything to be done that would increase the rate of fire or other insurance coverage on the Project and/or its contents. If Tenant does or permits anything to
be done that shall increase the cost of any insurance policy required to be carried hereunder, then Tenant shall not be in default under this Lease so long as Tenant reimburses Landlord, upon demand, for any such additional premiums. Landlord shall
deliver to Tenant a written statement setting forth the amount of any such insurance cost increase and showing in reasonable detail the manner in which it has been computed. 
  
 (c) Tenant herein covenants by and for himself or herself, his or her heirs, executors, administrators and assigns, and all
persons claiming under or through him or her, and this Lease is made and accepted upon and subject to the following conditions: That there shall be no discrimination against, or segregation of, any person or group of persons on account of race,
color, creed, religion, sex, marital status, sexual orientation, national origin or ancestry in the leasing, subleasing, transferring, use, occupancy, tenure or enjoyment of the Leased Premises herein leased, nor shall Tenant, or any person claiming
under or through him or her, establish or permit any such practice or practices of discrimination or segregation with reference to the selection, location, number, use or occupancy of tenants, lessees, subtenants, sublessees or vendees in the Leased
Premises herein leased. 
  
 5.11 Entry For Repairs,
Inspection, Posting Notices, Etc. After at least twenty-four (24) (or, if Landlord desires to enter Tenant’s clean rooms or wet labs, forty-eight (48)) hours’ prior notice (except in emergencies where no such notice shall be
required), Landlord or Landlord Parties shall have the right to enter the Leased Premises to inspect the same, to clean, to perform such work as may be permitted or required hereunder, to make repairs to or alterations of the Project or other tenant
spaces therein, to deal with emergencies, to post such notices as may be permitted or required by Law to prevent the perfection of liens against Landlord’s interest in the Project or to exhibit the Leased Premises to prospective tenants during
the last twelve (12) months of the Term, purchasers, encumbrancers or others; provided, however, that in exercising any such right of entry, Landlord shall not unreasonably interfere with Tenant’s business operations. Tenant shall not be
entitled to any abatement of Rent by reason of the exercise of any such right of entry. All such entries by Landlord shall be subject to Tenant’s reasonable security measures including, without limitation, Tenant’s right to escort Landlord
or Landlord Parties during the entire course of entry. 
  
 5.12
No Nuisance. Tenant shall conduct its business and control Tenant Parties without creating any nuisance, or interfering with, annoying, endangering or disturbing any other tenant or Landlord in its operation of the Project. Tenant shall
not place any loads upon the floor, walls or ceiling of the Leased Premises that endanger the structure nor place any harmful liquids or Hazardous Material in the drainage system of the Building. Tenant shall not permit any vibration, noise or
unreasonable odor to escape from the Leased Premises and shall not do or permit anything to be done within the Leased Premises which would adversely affect the quality of the air in the Building or about the Project. 
  

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	 	5.13	Subordination; Mortgagee Protection; Reciprocal Easement Agreements. 

  
 (a) Tenant agrees that this Lease and the rights of Tenant hereunder are subject and subordinate to the holder of or
beneficiary under any mortgage or deed of trust whether now or in the future encumbering the Project (the “Mortgage Lender”) and to any and all advances made thereunder, and interest thereon, and all modifications, renewals,
supplements, consolidations and replacements thereof. Tenant agrees, however, that the Mortgage Lender may at its option, unilaterally elect to subordinate, in whole or in part, by an instrument in form and substance satisfactory to such Lender, the
lien of such mortgage or deed of trust to this Lease. In such case, Tenant agrees to execute and to deliver to Landlord or such Mortgage Lender within ten (10) days after request any such subordination instrument or instruments requested by such
Lender. If Tenant fails or refuses to do so within such period and fails to cure such failure or refusal within five (5) business days after receipt of a second written request therefor by Landlord or such Mortgage Lender, such failure or refusal
shall constitute a default by Tenant under this Lease, but such failure or refusal shall in no way affect the validity or enforceability of any such subordination made by such Mortgage Lender. 
  
 (b) Any successor in interest to any Mortgage Lender shall not be bound by
(i) any payment of Gross Rent for more than one (1) month in advance, or (ii) any amendment or modification of this Lease made without the written consent of the Mortgage Lender. Nothing herein contained shall be deemed to impose upon the person or
party succeeding to the interest of Landlord as a result of the enforcement of such mortgage or first deed of trust by any Mortgage Lender, any obligation for defaults on the part of Landlord (except for continuing defaults with respect to the
physical condition of the Leased Premises), and any person or party succeeding to possession of the Project as a successor to Landlord shall be subject to Landlord’s obligations hereunder only during the period of such persons’ or
party’s ownership. 
  
 (c) Tenant shall not sue, seek any
remedy or enforce any right against Landlord as a result of Landlord’s failure to perform its obligations hereunder which remedy or right could lead to a termination of this Lease until (i) Tenant gives written notice to any Mortgage Lender and
(ii) a reasonable time for such Mortgage Lender, at its option, to remedy the act or omission has elapsed following the giving of notice by Tenant to Mortgage Lender required hereunder, including, without limitation, time to obtain possession from
Landlord by power of sale or judicial foreclosure, it being agreed that the Mortgage Lender shall have no obligation to Tenant to cure or remedy any act or omission of Landlord. 
  
 (d) Tenant agrees that this Lease and the rights of Tenant hereunder are subject and subordinate to any easements,
reciprocal easement agreements, rights of way, covenants, conditions and restrictions or similar property interests, whether now or in the future affecting the Project (collectively, the “REAs”); provided, however, that any future
REAs shall not materially adversely affect any specific rights granted to Tenant hereunder with respect to parking or access. Tenant agrees to execute and to deliver to Landlord within ten (10) days after request any subordination instrument or
instruments requested by Landlord. If Tenant fails or refuses to do so within such period and fails to cure such failure or refusal within five (5) business days after receipt of a second written request therefor by Landlord, such failure or refusal
shall constitute a default by Tenant under this Lease, but such failure or refusal shall in no way affect the validity or enforceability of any such subordination. 
  

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 (e) Notwithstanding the foregoing, this Lease shall not be subject to or subordinate to any ground or
underlying lease or to any lien, mortgage, deed of trust, or security interest now or hereafter affecting the Leased Premises, nor shall Tenant be required to execute any documents subordinating this Lease, unless the ground lessor, lender, or other
holder of the interest to which this Lease shall be subordinated contemporaneously executes a recognition and nondisturbance agreement which (i) provides that this Lease shall not be terminated so long as Tenant is not in default under this Lease
and (ii) recognizes all of Tenant’s rights hereunder (an “SNDA”). Landlord hereby confirms that there are no deeds of trust or mortgages encumbering the Project as of the date of this Lease. 
  
 5.14 Estoppel Certificate. Within ten (10) days of a written
request from Landlord, Tenant shall execute estoppel certificates addressed to (i) any mortgagee or prospective mortgagee of Landlord or, (ii) any purchaser or prospective purchaser of all or any portion of, or interest in, the Project, on a form
reasonably specified by Landlord, certifying as to such facts (if true) and agreeing to such notice provisions and other matters as such mortgagee(s) or purchaser(s) may reasonably require; provided, however, that in no event shall any such estoppel
certificate require an amendment of the provisions hereof, although Tenant shall be bound by the statements made in such certificate. In the event that Tenant fails or refuses to deliver such an estoppel certificate to Landlord within ten (10) days
of a written request from Landlord, then Landlord may give to Tenant a second notice, reiterating the request that Tenant execute an estoppel certificate in the form specified by Landlord and stating that, if Tenant fails to do so within five (5)
days of the receipt by Tenant of such second notice from Landlord, Tenant shall be deemed to be bound by the statements set forth in the form of certificate which Landlord requested that Tenant deliver. In the event that Tenant fails to deliver an
estoppel certificate in the form specified by Landlord within five (5) days of the receipt by Tenant of such second notice from Landlord, Tenant shall conclusively be deemed, without exception, to have acknowledged the correctness of the statements
set forth in the form of certificate which Landlord requested that Tenant deliver, and Tenant shall be estopped from denying the correctness of each such statement, such that a mortgage or purchaser may rely on the correctness of the statements in
such form of certificate, as if made and certified by Tenant. A failure by Tenant to deliver an estoppel certificate in the form specified by Landlord within five (5) days of the receipt by Tenant of such second notice shall also constitute a
material breach of this Lease by Tenant. 
  

	 	5.15	Letter of Credit. 

  
 (a) Upon execution of this Lease, Tenant shall deliver to Landlord, at Tenant’s sole cost and expense, the Letter of Credit described below in the
amount set forth in the Basic Lease Information (the “LC Face Amount”) as security for Tenant’s performance of all of Tenant’s covenants and obligations under this Lease. Neither the Letter of Credit nor any Letter of
Credit Proceeds (as defined below) shall be deemed an advance rent deposit or an advance payment of any other kind, or a measure of Landlord’s damages upon Tenant’s default. The Letter of Credit shall be maintained in effect from the
Effective Date through the date that is sixty (60) days after the Expiration Date (the “LC Termination Date”). On the LC Termination Date, Landlord shall return to Tenant the Letter of Credit and any Letter of Credit Proceeds then
held by Landlord (other than those Letter of Credit Proceeds Landlord is entitled to retain under the terms of this Section 5.15(a)); provided, however, that in no event shall any such return be construed as an 
  

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 admission by Landlord that Tenant has performed all of its obligations hereunder. Landlord shall not be required to
segregate the Letter of Credit Proceeds from its other funds and no interest shall accrue or be payable to Tenant with respect thereto. Landlord may (but shall not be required to) draw upon the Letter of Credit and use the proceeds therefrom (the
“Letter of Credit Proceeds”) or any portion thereof to the extent necessary (i) to cure any default under this Lease beyond applicable notice and cure periods and to compensate Landlord for any loss or damage Landlord incurs as a
result of such default, (ii) to repair damage to the Leased Premises caused by Tenant, (iii) to clean the Leased Premises upon termination of this Lease, and (iv) to reimburse Landlord for the payment of any amount which Landlord may spend or be
required to spend by reason of Tenant’s default beyond applicable notice and cure periods, it being understood that any use of the Letter of Credit Proceeds shall not constitute a bar or defense to any of Landlord’s remedies set forth in
Section 7.08(b) below. Landlord shall have the additional right to draw on the Letter of Credit in accordance with Section 5.15(c) below. In such event and upon written notice from Landlord to Tenant specifying the amount of the Letter of Credit
Proceeds so utilized by Landlord and the particular purpose for which such amount was applied, Tenant shall immediately deliver to Landlord an amendment to the Letter of Credit or a replacement Letter of Credit in an amount equal to the full LC Face
Amount. Tenant’s failure to deliver such replacement Letter of Credit to Landlord within ten (10) days of Landlord’s notice shall constitute an Event of Default hereunder. In the event Landlord transfers its interest in this Lease,
Landlord shall transfer the Letter of Credit and any Letter of Credit Proceeds then held by Landlord to Landlord’s successor in interest and Landlord or the transferee shall provide written notice of such transfer to Tenant and the Bank, and
thereafter Landlord shall have no further liability to Tenant with respect to such Letter of Credit or Letter of Credit Proceeds. 
  
 (b) As used herein, Letter of Credit shall mean an unconditional, standby irrevocable letter of credit (herein referred to as the “Letter of
Credit”) issued by the San Francisco office of a major national bank insured by the Federal Deposit Insurance Corporation, with assets of not less than Fifty Billion Dollars ($50,000,000,000.00) and otherwise reasonably satisfactory to
Landlord (collectively, the “Bank”), naming Landlord as beneficiary, in the amount of the LC Face Amount, and otherwise in form and substance reasonably satisfactory to Landlord. The Letter of Credit shall be for a minimum one-year
term, shall be automatically self-renewing for successive one-year terms (unless the Bank shall provide notices of non-renewal in accordance with Section 5.15(c) below), and shall provide: (i) that Landlord may make partial and multiple draws
thereunder, up to the face amount thereof; (ii) that Landlord may draw upon the Letter of Credit up to the full amount thereof and the Bank will pay to Landlord the amount of such draw upon receipt by the Bank of the original Letter of Credit and a
sight draft signed by Landlord and accompanied by a written certification from Landlord to the Bank stating that Landlord is entitled to draw on the Letter of Credit in such amount; and (iii) that the beneficial interest under the Letter of Credit
shall be freely transferable one or more times and, therefore, in the event of the assignment or other transfer of the interest of Landlord (or any successor Landlord) under this Lease, the Letter of Credit shall be freely transferable by Landlord
(or such successor), without recourse and without the payment of any fee or consideration in excess of Five Hundred Dollars ($500.00), to the assignee or transferee of such interest and the Bank shall confirm the same to Landlord (or such successor)
and such assignee or transferee. 
  
 (c) In the event that the
Bank shall at any time notify Landlord that the Letter of Credit shall not be renewed beyond the next expiry date, then unless Tenant shall, not less than 
  

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 thirty (30) days prior to such expiry date, deliver to Landlord a replacement Letter of Credit in the full LC Face Amount
and otherwise meeting the requirements set forth above, Landlord shall be entitled to draw on the Letter of Credit and shall hold the proceeds of such draw as Letter of Credit Proceeds pursuant to Section 5.15(a) above. The Letter of Credit shall
expressly provide that, to be effective, any notice on non-renewal given by the Bank must be provided by the Bank concurrently to Landlord, Landlord’s property manager and Landlord’s counsel (at the address of each such party specified in
the Letter of Credit). 
  
 (d) The LC Face Amount shall be subject
to reduction solely as hereinafter provided in this Section 5.15(d). 
  
 (i) Tenant shall have the right to reduce the LC Face Amount to a total of Two Hundred Sixty-Five Thousand Two Hundred Eighty-Four and 75/100 Dollars ($265,284.75), provided that the following conditions precedent shall have been satisfied
to Landlord’s reasonable satisfaction: 
  
 (A) Tenant shall
have achieved Profitability (as hereinafter defined) on a calendar quarter-by-calendar quarter basis for four (4) consecutive calendar quarters immediately preceding the proposed reduction date (the “Potential Reduction Date”); as
used herein, “Profitability” means Net Income (as hereinafter defined) attributable to the applicable calendar quarter of not less than One Dollar ($1.00), and “Net Income” means the net income (as calculated in
accordance with GAAP) earned by Tenant attributable to the applicable calendar quarter (specifically excluding, however, with respect to revenues, any non-recurring revenues or other revenues not received in the ordinary course of Tenant’s
business, such as proceeds under any policy of insurance maintained by Tenant, judgments rendered in favor of Tenant and other revenues or receipts of a non-recurring nature), all as determined in accordance with GAAP; 
  
 (B) Tenant shall have achieved Positive Cash Flow (as hereinafter defined)
on a calendar quarter-by-calendar quarter basis for four (4) consecutive calendar quarters immediately preceding the Potential Reduction Date; as used herein, “Positive Cash Flow” means, with respect to any calendar quarter, the
cash flow of Tenant (including, without limitation, cash flow from operating activities, financing activities and investing activities) attributable to such quarter, all as determined in accordance with GAAP; 
  
 (C) Tenant shall have maintained, at the time Tenant seeks the actual
reduction in the LC Face Amount, Cash and Cash Equivalents in an amount not less than Forty Million Dollars ($40,000,000.00); as used herein, “Cash and Cash Equivalents” means (1) cash, (2) demand deposits titled in the name of
Tenant and maintained with a major national bank insured by the Federal Deposit Insurance Corporation and otherwise reasonably satisfactory to Landlord (an “Acceptable Financial Institution”), (3) funds maintained in money market
accounts titled in the name of Tenant and established with an Acceptable Financial Institution, and (4) certificates of deposit issued by an Acceptable Financial Institution and titled in the name of Tenant; 
  
 (D) no Event of Default shall have occurred or be occurring hereunder either
(1) at any time during the calendar year immediately preceding the Potential Reduction Date, or (2) as of the Potential Reduction Date. In addition, if an event or condition which, with 
  

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 the giving of notice or the passage of time, or both, is occurring hereunder on the Potential Reduction Date, then
Tenant’s right to reduce the LC Face Amount shall be suspended until such event or condition has been cured or otherwise no longer exists. 
  
 (ii) Prior to any reduction in the LC Face Amount under this Section 5.15(d), Tenant shall deliver to Landlord such documentation as Landlord may request,
including, without limitation, financial statements for the applicable calendar year(s), which statements shall be audited by a certified public accountant from a nationally recognized accounting firm (the “CPA”), shall be certified
by the CPA as having been prepared in accordance with GAAP, and shall otherwise be reasonably acceptable to Landlord. 
  
 (iii) The right of Tenant to reduce the LC Face Amount as provided in this Section 5.15(d) shall be personal to FoxHollow Technologies, Inc. and shall be
available to FoxHollow Technologies, Inc. only during the period that FoxHollow Technologies, Inc. or a Qualified Tenant Affiliate is the actual tenant hereunder. 
  
 (e) Notwithstanding anything to the contrary in Section 5.15(a) above, Tenant has notified Landlord that Tenant may be
unable to deliver the Letter of Credit to Landlord concurrently with the execution of this Lease. Tenant shall have the right, in lieu of delivering such Letter of Credit, to furnish Landlord with a cash security deposit (the “Cash Security
Deposit”) in the full amount of the LC Face Amount, provided that Tenant shall deliver the Letter of Credit to Landlord satisfying the requirements of this Section 5.15 within ninety (90) days after the date of this Lease (whereupon
Landlord shall return the Cash Security Deposit to Tenant). Landlord shall have the right to use or apply the Cash Security Deposit for any purpose for which Landlord is entitled to draw on the Letter of Credit pursuant to Section 5.15(a) above.
Landlord shall not be required to keep the Cash Security Deposit separate from its general funds and Tenant shall not be entitled to any interest on such deposit. If Landlord uses or applies all or any portion of the Cash Security Deposit, within
five (5) days after written demand therefor Tenant shall deposit cash with Landlord in an amount sufficient to restore the Cash Security Deposit to the full extent of the above amount, and Tenant’s failure to do so shall be an Event of Default
under this Lease. In the event Landlord transfers its interest in this Lease prior to its receipt of the Letter of Credit, Landlord shall transfer the then remaining amount of the Cash Security Deposit to Landlord’s successor in interest, and
thereafter Landlord shall have no further liability to Tenant with respect to such Cash Security Deposit. 
  
 5.16 Tenant’s Remedies. Tenant shall look solely to Landlord’s interest in the Building for recovery of any judgment from
Landlord, including, without limitation, the rental, sale and insurance proceeds therefrom. Landlord and Landlord Parties shall not be personally liable for any such judgment. Any lien obtained to enforce any such judgment and any levy of execution
thereon shall be subject and subordinate to any lien, mortgage or deed of trust to which Section 5.13 applies or may apply. 
  
 5.17 Rules and Regulations. Tenant shall comply with the Rules and Regulations for the Project attached as Exhibit F and such
reasonable amendments thereto as Landlord may adopt from time to time with prior notice to Tenant. Landlord shall not be liable to Tenant for or in connection with the failure of any other tenant of the Project to comply with any rules and
regulations applicable to such other tenant under its lease, but Landlord shall use commercially reasonable efforts to cause other tenants to comply with such rules and regulations. Landlord shall not apply such rules and regulations in a
discriminatory manner. 
  

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	 	5.18	Prohibition and Indemnity With Respect To Hazardous Material. 

  

(a) Tenant shall not cause or permit any Hazardous Material to be brought upon, kept or used in or about the Leased Premises by Tenant or Tenant
Parties without the prior written consent of Landlord (which consent shall not be unreasonably withheld), save and except only for Permitted Hazardous Materials, which Tenant may bring, store and use in reasonable quantities for their intended use
in the Leased Premises, but only in full compliance with all Hazardous Materials Laws and otherwise in a safe and prudent manner. 
  
 (b) Notwithstanding the terms of Section 5.18(a) above, for so long as FoxHollow Technologies, Inc. or a Qualified Tenant Affiliate is the tenant
hereunder and is in actual possession of the Leased Premises (and specifically excluding possession by any sublessee or assignee other than a Qualified Tenant Affiliate), and provided that FoxHollow Technologies, Inc. or a Qualified Tenant Affiliate
is then using the Leased Premises for a Customary Use, Tenant shall have the right to commence the use of any Tenant-Specific Hazardous Materials in the Leased Premises without first obtaining the prior written consent of Landlord, subject, however,
to compliance with the terms of this Section 5.18(b). Within ten (10) business days after Tenant commences the use of any Tenant-Specific Hazardous Materials in the Leased Premises, Tenant shall provide written notice thereof to Landlord. Landlord
shall thereafter have the right to approve or disapprove such Tenant-Specific Hazardous Materials, provided that Landlord will not disapprove the same so long as Tenant takes such measures as may be recommended by Landlord’s consultants from
time to time to prevent the potential spill or release of such Tenant-Specific Hazardous Material, to prevent fumes or odors from escaping the Leased Premises, and to properly contain flammable or combustible materials (the “Handling
Recommendations”). Tenant shall promptly cease the use of any Tenant-Specific Hazardous Materials if Tenant fails to follow such Handling Recommendations. Landlord shall only impose Handling Recommendations where the nature of the
particular Tenant-Specific Hazardous Material reasonably justifies the Handling Recommendations, as advised by Landlord’s consultants. 
  
 (c) If Tenant breaches the obligations stated in Sections 5.18(a) and (b) above, or if contamination of the Leased Premises by Hazardous Material is
caused by Tenant or Tenant Parties, or if Tenant’s activities or those of Tenant Parties (or those of its subtenants) result in a release of Hazardous Materials, then Tenant shall indemnify, defend, protect and hold Landlord and Landlord
Parties harmless from and against any and all claims, judgments, damages, penalties, fines, costs, expenses, liabilities or losses (including, without limitation, diminution in value of the Leased Premises, damages for the loss or restriction on use
of rentable or useable space or of any amenity of the Leased Premises, damages arising from any adverse impact on marketing of space, and sums paid in settlement of claims, reasonable attorneys’ fees, consultants’ fees and experts’
fees) (collectively, “Claims”) which arise during or after the Term as a result of such contamination. This indemnification of Landlord by Tenant includes, without limitation, costs incurred in connection with any investigation of
site conditions or any clean-up, remedial, removal or restoration work required by any federal, state or local governmental agency or political subdivision because of Hazardous Material released by Tenant or Tenant Parties present in the soil or
ground water on or under the Leased Premises. The foregoing indemnity shall survive the expiration or earlier termination of this Lease. 
  

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 (d) Notwithstanding anything to the contrary contained in Sections 5.18(a) through (c) above, Tenant
shall not be responsible for the inspection, cleanup or remediation of, and shall not be required to indemnify Landlord against any costs or liabilities attributable to, any Hazardous Materials existing on or about the Leased Premises prior to the
date of this Lease or otherwise not released by Tenant or any Tenant Parties (the “Non-Tenant Hazardous Materials”), except to the extent that the contamination caused by such Non-Tenant Hazardous Materials has been exacerbated by
Tenant or any Tenant Parties or by Tenant’s failure to perform its obligations under this Section 5.18. As between Landlord and Tenant, Landlord shall be responsible for the cleanup or remediation of any Non-Tenant Hazardous Materials, except
to the extent that the contamination caused by such Non-Tenant Hazardous Materials has been exacerbated by Tenant or Tenant’s Agents or by Tenant’s failure to perform its obligations under this Section 5.18; provided, however, that
Landlord shall not be required to undertake any cleanup or remedial actions unless Landlord is ordered to do so by governmental authorities or a court of competent jurisdiction (Landlord hereby specifically reserving the right to negotiate the
timing and scope of any such cleanup or remedial actions); and provided, further, that Landlord expressly reserves all rights (including, without limitation, all rights of contribution) against third parties responsible, directly or indirectly, for
any such Non-Tenant Hazardous Materials. 
  
 (e) Landlord hereby
assigns to Tenant, without in any way limiting the indemnity as it applies to Landlord and the Landlord Parties, on a non-exclusive basis, all rights provided under the R&H Indemnity (as hereinafter defined), it being the intention of the
parties that, in the event Tenant suffers a loss of the nature covered by the R&H Indemnity, Tenant shall have the right to enforce the R&H Indemnity obligations as if Tenant were a direct party to the R&H Indemnity. As used herein,
“R&H Indemnity” means that certain indemnification by Rohm & Haas Company, a Delaware corporation, of Chestnut Bay LLC (as assigned to Landlord), a copy of which is attached hereto and incorporated herein as Exhibit
H. 
  
 5.19 Surrender of Premises On
Termination. On or before the ninetieth (90th) day preceding the Term Expiration Date, Tenant shall notify Landlord in writing of the precise date upon which Tenant plans to surrender the Leased Premises to Landlord. On expiration of the
Term, Tenant shall quit and surrender the Leased Premises to Landlord, broom clean, in good order, condition and repair as required by Section 5.05, with all of Tenant’s movable equipment, furniture, trade fixtures and other personal property
removed therefrom. Subject to Section 2.02(b) and 5.08(c) above and Paragraph 12 of Exhibit D hereto, all Roof Top Equipment, Alterations and Tenant Improvements shall be surrendered with the Leased Premises in good condition and
repair, reasonable wear and tear (but only to an extent consistent with the Leased Premises and the Building remaining in good condition and repair) and casualty damage excepted. In the event that, pursuant to said Sections 2.02(b) and 5.08(a) above
and Paragraph 12 of Exhibit D, Tenant is required to remove any Roof Top Equipment, Alterations and/or Tenant Improvements from the Leased Premises and/or the Building, as applicable, then Tenant shall remove such Roof Top Equipment,
Alterations and/or Tenant Improvements, as applicable, and restore the Leased Premises and the Building to the condition that existed prior to the installation of the same, before the regularly scheduled Term Expiration Date (or if this Lease is
sooner terminated, within thirty (30) days thereafter). Any property of Tenant not removed 
  

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 hereunder shall be deemed, at Landlord’s option, to be abandoned by Tenant and Landlord may store such property in
Tenant’s name at Tenant’s expense, and/or dispose of the same in any manner permitted by Law. Tenant shall repair at its sole cost and expense, all damage caused to the Leased Premises, the Building and the Project by removal of
Tenant’s movable equipment or furniture and such Roof Top Equipment, Tenant Improvements and Alterations as Tenant shall be allowed or required to remove from the Leased Premises by Landlord. Without limiting the foregoing, Tenant acknowledges
and hereby agrees that Landlord’s rights to require removal of any Roof Top Equipment and Alterations hereunder shall extend to the right to require removal of any conduit, wiring, cabling or other telecommunications equipment located installed
anywhere within the Project by or on behalf of Tenant; provided, however, that Landlord shall not require Tenant to remove any wiring or cabling that is useable by a successor tenant or occupant of the Building and in good condition and repair. If
the Leased Premises are not surrendered as of the end of the Term in the manner and condition herein specified, Tenant shall indemnify, defend, protect and hold Landlord and Landlord Parties harmless from and against any and all Claims resulting
from or caused by Tenant’s delay or failure in so surrendering the Leased Premises, including, without limitation, any Claims made by any succeeding tenant due to such delay or failure. Tenant acknowledges that Landlord will be attempting to
lease the Leased Premises with any such lease to be effective upon expiration of the Term, and failure to surrender the Leased Premises could cause Landlord to incur liability to such successor tenant for which Tenant shall be responsible hereunder
to the full extent thereof; provided, however, that in no event shall Tenant be liable for any consequential damages incurred by the successor tenant. 
  
 5.20 Window Coverings. Tenant shall not replace any of the window coverings, blinds or drapes on the exterior windows existing on the Term
Commencement Date, other than those in compliance with Landlord’s standards, without Landlord’s prior written approval, which Landlord shall have the right to grant or withhold in its absolute and sole discretion. Tenant acknowledges that
breach of this covenant will directly and adversely affect the exterior appearance of the Project and/or the operation of the heating, ventilation or air conditioning systems. 
  
 ARTICLE 6 
  
 Condition and Operation of the Building 
  

	 	6.01	As-Is Condition. 

  
 (a) Tenant understands and agrees that the Leased Premises, including, without limitation, the existing improvements therein and the Building Systems
servicing the Leased Premises, shall be leased by Tenant in its existing As-Is condition without any improvements, alterations, upgrades or enhancements by Landlord, and that all improvements shall be made by Tenant in accordance with Section 5.02
above and Exhibit D hereto. Landlord shall have no other obligation of any kind or character, express or implied, with respect to the condition of the Leased Premises or the suitability thereof for Tenant’s purposes or with
respect to alterations, additions, improvements, upgrades or enhancements to the Leased Premises, the Building Systems, the Building or the Project, and Tenant acknowledges that it has neither received nor 
  

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 relied upon any representation or warranty made by or on behalf of Landlord with respect to such matters. Without
limiting the foregoing, Tenant acknowledges that it has not received any representation or warranty regarding the existing improvements in the Leased Premises (including, without limitation, the quantity, quality and nature of any particular
improvements located within the Leased Premises irrespective of any statement or designation of Building Standard Improvements set forth herein). By entry hereunder, Tenant accepts the Leased Premises as suitable for Tenant’s intended use and
as being in good and sanitary operating order, condition and repair, As-Is and without representation or warranty by Landlord as to the condition, use or occupancy which may be made thereof. 
  
 (b) Notwithstanding the foregoing terms of Section 6.01(a), Landlord shall
deliver the Leased Premises with the roof in good condition and all Building Systems in good working condition and repair. Tenant shall give notice to Landlord of any repairs reasonably required thereto within thirty (30) days of the Delivery Date,
in which event Landlord shall make such repairs as may be required at no cost to Tenant (through Building Operating Cost or otherwise). In the event Tenant fails to deliver a written claim to Landlord on or before such thirtieth (30th) day, then
Landlord shall be conclusively deemed to have satisfied its obligations under this Section 6.01. 
  
 6.02 Alteration. Landlord may, at any time and from time to time: (i) make alterations, structural modifications, seismic modifications or
additions to the Building; (ii) change, add to, eliminate or reduce the extent, size, shape or configuration of any aspect of or improvement (including the Building) within the Project or its operations (including, without limitation, parcelizing
the Project into one or more separate legal lots and/or realigning boundary lot lines of any such legal lots now or hereafter comprising the Project (collectively “Parcelization”)); and (iii) change the name, number or designation
by which the Building or the Project is commonly known. None of the foregoing acts shall be deemed an actual or constructive eviction of Tenant, shall entitle Tenant to any reduction of Rent or shall result in any liability of Landlord to Tenant.
Landlord shall have the exclusive rights to the airspace above and around, and the subsurface below, the Leased Premises, the Building and other portions of the Project, including, without limitation, the exclusive right to use all exterior walls,
roofs and other portions of the Building (including, without limitation, the right to install any equipment, antennas, signs, notices or other promotional items). Landlord agrees that it shall not, in exercising its rights hereunder, make any
alterations or changes that would unreasonably interfere with Tenant’s use of the Leased Premises (or the roof as described in Section 2.02) or Tenant’s parking rights. In exercising its rights hereunder, Landlord shall use reasonable
efforts to minimize disruption to Tenant’s business operations. Without limiting the foregoing, Tenant agrees to fully cooperate with Landlord to allow Landlord to accomplish any such Parcelization, as referenced in clause (ii) above, and
acknowledges that the real property currently comprising the Project may be operated as an integrated project irrespective of any such Parcelization. Landlord shall reimburse Tenant all of Tenant’s reasonable costs in connection therewith.

  

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 ARTICLE 7 
  

Casualty, Eminent Domain and Miscellaneous Matters 
  
 7.01 Landlord’s Casualty Insurance. Landlord shall maintain, or cause to be maintained, a policy or
policies of insurance with the premiums thereon fully paid in advance, issued by and binding upon an insurance company of good financial standing, insuring the Project against loss or damage by fire or other insurable hazards (that may include
earthquake loss if Landlord elects to maintain such coverage) and contingencies for the full insurable value thereof, or, in the alternative, insuring for one hundred percent (100%) of the replacement cost thereof, exclusive of excavations and
foundations; provided, however, that Landlord shall not be obligated to insure any of Tenant’s Personal Property, or any Tenant Extra Improvements or Alterations that Tenant may make upon the Leased Premises. If the annual premiums charged
Landlord for such casualty insurance exceed the standard premium rates and such excess is attributable to the Alterations or to the particular nature of Tenant’s operations in the Leased Premises, including, without limitation, a determination
that such operations result in extra-hazardous or higher than normal risk exposure, then Tenant shall, upon receipt of appropriate premium invoices, reimburse Landlord for such increases in premium. All insurance proceeds payable under
Landlord’s insurance carried hereunder shall be payable solely to Landlord, and Tenant shall have no interest therein. For purposes of clarity, “Tenant Improvements” do not constitute “Alterations” under this Lease.

  
 7.02 Liability Insurance. Landlord (with respect
to the Project) and Tenant (with respect to the Leased Premises and Project) shall each maintain or cause to be maintained a policy or policies of commercial general liability insurance with the premiums thereon fully paid in advance, issued by and
binding upon an insurance company of good financial standing, such insurance to afford minimum protection of not less than Two Million Dollars ($2,000,000.00) combined single limit for bodily injury and property damage in any one occurrence. The
coverages required to be carried shall be extended to include, but not to be limited to, blanket contractual liability, personal injury liability (libel, slander, false arrest and wrongful eviction), and broad form property damage liability.
Tenant’s contractual liability insurance shall apply, without limitation, to all of Tenant’s indemnity obligations under this Lease. The certificate evidencing Tenant’s insurance coverage required hereunder shall state that the
insurance includes the liability assumed by Tenant under this Lease and that Tenant’s insurance is primary with any other insurance available to Landlord or any other named insured being excess. Upon request of Landlord, Tenant shall provide
Landlord reasonable evidence that the insurance required to be maintained hereunder by Tenant is in full force and effect. 
  

	 	7.03	Tenant’s Casualty Insurance and Additional Tenant Insurance Requirements. 

  
 (a) Tenant shall provide insurance coverage during the Term against loss or damage by fire and such other risks as are from
time to time included in an Insurance Services Offices (ISO) “Causes of Loss – Special Form” policy (including, without limitation, sprinkler leakage and water damage), insuring the full insurable value of any Tenant Extra
Improvements, any Alterations, Tenant’s trade fixtures, furnishings, equipment, and all other items of personal property of Tenant, insuring the full replacement cost thereof. 
  

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 (b) All policies required to be carried by Tenant under this Article 7 shall be written with financially
responsible companies with a Best & Company rating of A:VIII or better, and all evidence of insurance provided to Landlord shall contain an endorsement showing that Landlord and Mortgage Lender are included as an additional insured and an
endorsement whereby the insurer agrees not to cancel or alter the policy without at least thirty (30) days’ prior written notice to Landlord and all named and additional insureds. Any deductible or self-insurance provisions under any insurance
policies maintained by Tenant shall be subject to Landlord’s prior written approval which shall not be unreasonably withheld. 
  
 (c) Prior to the Term Commencement Date and thereafter, from time to time, promptly upon request by Landlord, Tenant shall furnish Landlord and any
additional insureds with copies of policies or certificates of insurance, evidencing Tenant’s maintenance and renewal of the required coverages. If Tenant fails to provide such evidence of insurance required hereunder, Landlord shall be
authorized (but not required) to procure such coverage in the amounts stated with all costs thereof to be charged to Tenant and paid upon written invoice therefor as Additional Rent together with an administrative fee equal to fifteen percent (15%)
of such costs. 
  

	 	7.04	Indemnity and Exoneration. 

  
 (a) Except to the extent arising from Landlord’s gross negligence or willful misconduct, Landlord shall not be liable to Tenant (i) for any loss,
damage or injury to person or property caused by theft, fire, vandalism, assault, battery, act of God, acts of the public enemy, acts of terrorists or criminals, riot, strike, insurrection, war, court order, requisition or order of governmental body
or authority, whether or not the negligence of Landlord was a partial cause of such loss, damage or injury, or (ii) that occur by reason of the negligence or willful misconduct of Tenant or Tenant Parties, or (iii) for any damage or inconvenience
which may arise through repair or alteration of any part of the Project or failure to make any such repair except as expressly otherwise provided in Sections 7.06 and 7.07. Without limiting the foregoing and notwithstanding anything to the contrary
herein, Tenant acknowledges that no security services are being provided to the Leased Premises, and to the extent any security service is being provided to the Project by Landlord, such security service shall be provided by unarmed personnel and
shall not include alarm systems for a special surveillance of the Leased Premises or the Project, and Tenant agrees that Landlord shall not be liable to Tenant or any third party for any breach of security or any losses due to theft, burglary,
battery or for damage done or injury inflicted by persons (other than the employees of Landlord) in or on the Project. Notwithstanding the foregoing, Landlord shall be liable for actual damages to person or property directly resulting from the
failure of Landlord to make any repair expressly required to be made by Tenant under the terms of this Lease, provided that (A) such failure persists for an unreasonable period of time following receipt by Landlord of written notice of default from
Tenant, (B) such damages are not covered by any policy of insurance actually carried by Tenant or required to be carried by Tenant under the terms of this Lease, and (C) in no event shall Landlord be liable for consequential damages. 
  
 (b) Tenant shall indemnify, defend, protect and hold Landlord and Landlord
Parties harmless from and against any and all Claims arising out of or related to claims of injury to or death of persons, damage to property occurring or resulting directly or indirectly from the use or 
  

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 occupancy of the Leased Premises or activities of Tenant or its employees in or about the Leased Premises or Project;
provided, however, that the foregoing indemnity shall not be applicable to claims arising by reason of the negligence or willful misconduct of Landlord or the Landlord Parties or a breach of the obligations of Landlord under this Lease, unless
covered by insurance required to be carried by Tenant under the terms of this Lease. 
  
 (c) Tenant shall indemnify, defend and protect Landlord and hold and save Landlord harmless of and from any and all loss, claims, proceedings, cost, damage, injury, causes of action, liabilities or expense or other
Claims arising out of or in any way related to work or labor performed, materials or supplies furnished to or at the request of Tenant or in connection with performance of any work done for the account of Tenant in the Leased Premises or the
Project. 
  
 (d) Landlord shall indemnify, defend, protect and
hold Tenant and the Tenant Parties harmless from and against any and all claims, liabilities, judgments, costs, demands, causes of action and expenses arising from (i) the death of or injury to persons or damage to property caused by Landlord or its
employees or authorized agents while entering upon the Leased Premises or the Project, (ii) the gross negligence or willful misconduct of Landlord or from any breach or default in the terms of this Lease by Landlord (if such breach or default
persists for an unreasonable period of time after written notice thereof to Landlord), and (iii) any action or proceeding brought on account of any matter in item (i) or item (ii). 
  
 7.05 Waiver of Subrogation Rights. Anything in this Lease to the contrary notwithstanding, Landlord and Tenant
each waive all rights of recovery, claim, action or cause of action, against the other, Tenant Parties or Landlord Parties, as applicable, for any loss or damage that may occur to the Leased Premises, or any improvements thereto, or the Project or
any personal property of such party therein, by reason of fire, the elements, or any other cause that could be insured against under the terms of an ISO “Causes of Loss – Special Form” insurance policy or other casualty insurance
coverages which are required to be obtained pursuant to this Lease, regardless of cause or origin, including negligence of the other party, Landlord Parties or Tenant Parties, as applicable; and each party covenants that no insurer shall hold any
right of subrogation against such other party. Landlord and Tenant shall advise its insurers of the foregoing and such waiver shall be a part of each property insurance policy maintained by Landlord and Tenant that applies to the Leased Premises,
any part of the Project or Tenant’s use and occupancy of any part thereof. 
  

	 	7.06	Condemnation. 

  
 (a) If the Leased Premises or any portion of the Project shall be taken or condemned for any public purpose to such an extent as to render the Leased
Premises untenantable or unsuitable for Tenant’s operations, this Lease shall, at the option of either party, forthwith cease and terminate as of the date of taking. All proceeds from any taking or condemnation of the Leased Premises shall
belong to and be paid to Landlord subject to the rights of any Mortgage Lender; provided, however, that Landlord shall cooperate with Tenant, at Tenant’s sole cost and expense, if Tenant seeks to recover proceeds, damages or awards paid to
compensate for damage to or taking of Tenant’s Personal Property and for the unamortized cost of the Tenant Improvements or Alterations to the extent paid for by Tenant. 
  

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 (b) If a temporary or permanent taking of all or a portion of the Leased Premises occurs, there shall be
an equitable abatement of Rent. 
  
 7.07 Damage and
Destruction. If a fire or other casualty in the Leased Premises occurs, Tenant shall immediately give notice thereof to Landlord. In the event of a fire or other casualty in any portion of the Building, the following provisions shall then
apply: 
  
 (a) If the damage is to the Leased Premises and the
Leased Premises can, in the reasonable opinion of Landlord, be made tenantable with all damage repaired within twelve (12) months from the date of damage or destruction, then Landlord shall diligently rebuild the same including, without limitation,
Tenant Improvements which are not Tenant Extra Improvements. If Landlord rebuilds the Leased Premises, Tenant shall repair and restore any Tenant Extra Improvements and any Alterations or, at Landlord’s election, Landlord may repair and rebuild
the Tenant Extra Improvements and/or Alterations, at Tenant’s sole cost and expense. 
  
 (b) If the damage is to the Leased Premises and the Leased Premises cannot, in the reasonable opinion of Landlord, be made tenantable with all damage repaired within twelve (12) months from the date of damage or
destruction, then either Tenant or Landlord may terminate this Lease within thirty (30) days after the date of such notice. 
  
 (c) During any period when Tenant’s use of the Leased Premises is significantly affected by damage or destruction, Gross Rent shall abate
proportionately until such time as the Leased Premises are made tenantable as reasonably determined by Landlord, and no portion of the Rent so abated shall be subject to subsequent recapture. 
  
 (d) The proceeds from any insurance paid by reason of damage to or
destruction of the Building or any part thereof, or any other element, component or property insured by Landlord shall belong to and be paid to Landlord subject to the rights of any mortgagee of Landlord’s interest in the Project or the
beneficiary of any deed of trust that constitutes an encumbrance thereon. If this Lease is terminated by either party as a consequence of a casualty in accordance with any of the provisions of this Section 7.07(d), all proceeds of property insurance
with respect to the Leased Premises required to be maintained either by Landlord or Tenant shall be paid to Landlord subject to the rights of any mortgagee of Landlord’s interest in the Project or the beneficiary of any deed of trust that
constitutes an encumbrance thereon; provided, however, that Tenant shall be paid all proceeds of insurance payable in connection with Tenant’s trade fixtures, furnishings, equipment and all other items of personal property of Tenant and the
unamortized value (such amortization to be calculated on a straight-line basis over the Term) of any Tenant Extra Improvements actually funded by Tenant (and specifically excluding any portion paid for with Landlord’s Contribution) and
remaining in the Leased Premises immediately prior to the occurrence of the damage or destruction. 
  
 (e) If the Leased Premises, or any part thereof, or any portion of the Building is damaged or destroyed during the last twelve (12) months of the Term, or
any extension thereof, Landlord may terminate this Lease by giving written notice thereof to Tenant within thirty (30) days after the date of the casualty, in which case this Lease shall terminate as of the date of the casualty. 
  

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 (f) Except to the extent expressly provided in this Lease, nothing contained in this Lease shall relieve
Tenant of any liability to Landlord or to Landlord’s insurance carriers that Tenant may have under Law or under the provisions of this Lease in connection with any damage to the Leased Premises or the Building by fire or other casualty.

  

	 	7.08	Default By Tenant. 

  
 (a) Events of Default. The occurrence of any of the following shall constitute an event of default (“Event of Default”) on the
part of Tenant: 
  
 (i) Abandonment. Abandonment of the
Leased Premises for a continuous period in excess of five (5) business days. Tenant waives any right to notice Tenant may have under Section 1951.3 of the Civil Code of the State of California, the terms of this Section 7.08(a)(i) being deemed such
notice to Tenant as required by said Section 1951.3; 
  
 (ii)
Nonpayment of Rent. Failure to pay any installment of Gross Rent or items of Additional Rent or any other amount to be paid by Tenant hereunder, upon the date when payment is due where such failure shall continue for five (5) business days
after written notice to Tenant of such failure (provided, however, that Landlord shall not be required to deliver, and Tenant shall not be entitled to receive, such notice more than two (2) times in any twelve (12) month period); 
  
 (iii) Other Obligations. Failure to perform any obligation, agreement
or covenant under this Lease other than those matters specified in Sections 7.08(a)(i) and 7.08(a)(ii), such failure continuing for fifteen (15) business days after written notice of such failure (or with respect to non-monetary obligations only,
such longer period as is reasonably necessary to remedy such default, provided that Tenant shall continuously and diligently pursue such remedy at all times until such default is cured); 
  
 (iv) General Assignment. A general assignment by Tenant for the benefit of creditors; 
  
 (v) Bankruptcy. The filing of any voluntary petition in bankruptcy by
Tenant, or the filing of an involuntary petition by Tenant’s creditors, which involuntary petition remains undischarged for a period of thirty (30) days. If under applicable Law the trustee in bankruptcy or Tenant has the right to affirm this
Lease and continue to perform the obligations of Tenant hereunder, such trustee or Tenant shall, in such time period as may be permitted by the bankruptcy court having jurisdiction, cure all defaults of Tenant hereunder outstanding as of the date of
the affirmance of this Lease and provide to Landlord such adequate assurances as may be necessary to ensure Landlord of the continued performance of Tenant’s obligations under this Lease; 
  
 (vi) Receivership. The employment of a receiver to take possession of
substantially all of Tenant’s assets or the Leased Premises, if such receivership remains undissolved for a period of ten (10) business days after creation thereof; 
  
 (vii) Attachment. The attachment, execution or other judicial seizure of all or substantially all of Tenant’s
assets or the Leased Premises, if such attachment or other seizure remains undismissed or undischarged for a period of ten (10) business days after the levy thereof; 
  

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 (viii) Insolvency. The admission by Tenant in writing of its inability to pay its debts as they
become due, the filing by Tenant of a petition seeking any reorganization, arrangement, composition, readjustment, liquidation, dissolution or similar relief under any present or future Law, the filing by Tenant of an answer admitting or failing
timely to contest a material allegation of a petition filed against Tenant in any such proceeding or, if within thirty (30) days after the commencement of any proceeding against Tenant seeking any reorganization, or arrangement, composition,
readjustment, liquidation, dissolution or similar relief under any present or future Law, such proceeding shall not have been dismissed. 
  
 (b) Remedies Upon Default. 
  
 (i) Termination. If an Event of Default occurs, Landlord shall have the right, with or without notice or demand, immediately (after expiration of
the applicable grace periods specified herein) to terminate this Lease, and at any time thereafter recover possession of the Leased Premises or any part thereof and expel and remove therefrom Tenant and any other person occupying the same, by any
lawful means, and again repossess and enjoy the Leased Premises without prejudice to any of the remedies that Landlord may have under this Lease, or at law or equity by reason of Tenant’s default or of such termination. 
  
 (ii) Continuation After Default. Even though Tenant has breached this
Lease and/or abandoned the Leased Premises, this Lease shall continue in effect for so long as Landlord does not terminate Tenant’s right to possession under Section 7.08(b)(i) hereof, and Landlord may enforce all of its rights and remedies
under this Lease, including, without limitation, the right to recover Rent as it becomes due. Landlord has the remedy described in Section 1951.4 of the Civil Code of the State of California or any successor code section (Landlord may continue this
Lease in effect after Tenant’s breach and abandonment and recover rent as it becomes due, if Tenant has the right to sublet or assign, subject only to reasonable limitations). Acts of maintenance, preservation or efforts to lease the Leased
Premises or the appointment of receiver upon application of Landlord to protect Landlord’s interest under this Lease shall not constitute an election to terminate Tenant’s right to possession. 
  
 (c) Damages Upon Termination. Should Landlord terminate this Lease
pursuant to the provisions of Section 7.08(b)(i) hereof, Landlord shall have all the rights and remedies of a landlord provided by Section 1951.2 of the Civil Code of the State of California, or successor code section. Upon such termination, in
addition to any other rights and remedies to which Landlord may be entitled under applicable Law, Landlord shall be entitled to recover from Tenant: (i) the worth at the time of award of the unpaid Rent and other amounts which had been earned at the
time of termination; (ii) the worth at the time of award of the amount by which the unpaid Rent which would have been earned after termination until the time of award exceeds the amount of such Rent loss that Tenant proves could have been reasonably
avoided; (iii) the worth at the time of award of the amount by which the unpaid Rent for the balance of the Term after the time of award exceeds the amount of such Rent loss that Tenant proves could be reasonably avoided; and (iv) any other amount
necessary to compensate Landlord for all the detriment proximately caused by Tenant’s failure to perform its obligations under this Lease or which, in 
  

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 the ordinary course of things, would be likely to result therefrom. The “worth at the time of award” of
the amounts referred to in (i) and (ii) shall be computed with interest at twelve percent (12%) per annum or the highest lawful rate, whichever is the lower. The “worth at the time of award” of the amount referred to in (iii) shall
be computed by discounting such amount at the “discount rate” of the Federal Reserve Bank of San Francisco in effect as of time of award plus one percent (1%) and, where rental value is a material issue, shall be based upon competent
appraisal evidence. 
  
 (d) Computation of Rent For Purposes of
Default. For purposes of computing unpaid Rent that would have accrued and become payable under this Lease pursuant to the provisions of Section 7.08(c), unpaid Rent shall consist of the sum of: 
  
 (i) the total Base Rent for the balance of the Term, plus 
  
 (ii) a computation of the Building Operating Cost for the balance of the
Term, the assumed Building Operating Cost for the calendar year of the default and each future calendar year in the Term to be equal to the Building Operating Cost for the calendar year prior to the year in which default occurs compounded at a per
annum rate equal to the mean average rate of inflation for the preceding five (5) calendar years as determined by reference to the Consumer Price Index—all items for the San Francisco-Oakland-San Jose Area, All Urban Consumers, published by the
Bureau of Labor Statistics of the United States Department of Labor (Base Year 1982-84=100), or such successor index as may be established to provide a measure of the current purchasing power of the dollar. 
  
 (e) Late Charge. In addition to its other remedies, after written
notice of its intention to invoke this paragraph because of previous late payments by Tenant, Landlord shall have the right to add to the amount of any payment required to be made by Tenant hereunder that is not paid on or before the date the same
is due, an amount equal to Two Hundred Fifty Dollars ($250.00) plus five percent (5%) of the delinquency for each month or portion thereof that the delinquency remains outstanding, the parties agreeing that Landlord’s damage by virtue of such
delinquencies would be difficult to compute and the amount stated herein represents a reasonable estimate thereof. The provision for a late charge set forth in this Section 7.08(e), and any collection of a late charge by Landlord, shall not be
deemed a waiver of any breach or Event of Default by Tenant under this Lease. The late charge shall be due upon demand by Landlord at any time after failure to pay any installment of Rent, and in the case of Gross Rent, without waiting for
expiration of the period specified in Section 7.08(a)(ii). Notwithstanding the foregoing, Tenant shall be entitled to one notice of late payment and a five (5) day cure period in each twelve (12) month period before any such late charge accrues.

  
 (f) Landlord’s Right to Perform. In addition to
and without limiting its other remedies hereunder, Landlord shall have the right, but not the obligation, to perform Tenant’s obligations for Tenant’s account, including, without limitation, the right to perform any repair, maintenance or
replacement required to be performed by Tenant under Section 5.05, and the right to pay any amounts due to the providers of any Utilities pursuant to Section 5.03. All costs incurred by Landlord in performing any such obligations for the account of
Tenant shall be repaid by Tenant to Landlord upon demand, together with an administration fee equal to fifteen percent (15%) of such costs. 
  

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 (g) Remedies Cumulative. All of the remedies permitted or available to Landlord under this Lease,
or at law or in equity, shall be cumulative and not alternative and invocation of any such right or remedy shall not constitute a waiver or election of remedies with respect to any other permitted or available right or remedy. 
  

	 	7.09	Option to Extend the Term at Fair Market Rent. 

  
 (a) Subject to the terms of this Section 7.09, Tenant shall have one (1) option (the “Renewal Option”), to extend the Term of this Lease
for a consecutive period of five (5) years beyond the Term Expiration Date (the “Renewal Term”). The Renewal Option is personal to FoxHollow Technologies, Inc. and its Qualified Tenant Affiliates, and may not be exercised by any
sublessee or assignee (other than a Qualified Tenant Affiliate), or by any other successor or assign, of Tenant. The Renewal Option must be exercised, if at all, by written notice (“Election Notice”) from Tenant to Landlord given
not more than twenty-four (24) months nor less than eighteen (18) months prior to the Term Expiration Date. Except as expressly provided in Section 7.09(b) below, any such Election Notice given by Tenant to Landlord shall be irrevocable. The Renewal
Option and Tenant’s delivery of an Election Notice shall be effective only if, at the time of Tenant’s delivery of the Election Notice and at the time of commencement of the Renewal Term, no Event of Default is occurring under this Lease.
If Tenant fails to exercise the Renewal Option in a timely manner as provided for above, the Renewal Option shall be void. The Renewal Term shall be upon the same terms and conditions as the initial Term, except that the annual Base Rent during the
Renewal Term shall be equal to the Fair Market Rent as of the commencement of the Renewal Term; provided, however, that in no event shall the Base Rent during the Renewal Term be less than the Base Rent payable hereunder immediately prior to the
commencement of the Renewal Term. 
  
 (b) Fair Market Rent for the
Renewal Term shall be determined by Landlord with written notice (the “Renewal Rate Notice”) given to Tenant at least three hundred ninety-five (395) days (i.e., one year and 30 days) prior to the commencement of the Renewal
Term. Tenant shall have a period of thirty (30) days after receipt of the Renewal Rate Notice to provide Landlord with written notice (“Tenant’s Response Notice”) of Tenant’s election to (i) accept the Base Rent for the
Renewal Term specified in the Renewal Rate Notice, (ii) reject the Base Rent specified in the Renewal Rate Notice and rescind Tenant’s Election Notice and the exercise of the Renewal Option (which rescission shall be irrevocable), or (iii)
reject the Base Rent specified in the Renewal Rate Notice and submit the determination of Base Rent to arbitration pursuant to the provisions of Section 7.09(c) below. Failure on the part of Tenant to reject Landlord’s determination of Base
Rent by written notice to Landlord (whether pursuant to clause (ii) or (iii) above) within thirty (30) days after receipt of the Renewal Rate Notice shall be deemed an acceptance by Tenant under the foregoing clause (i) and shall bind Tenant to the
Fair Market Rent as determined by Landlord. Should Tenant elect to rescind its Election Notice in accordance with the foregoing clause (ii), then the Term shall expire on the Term Expiration Date and Tenant shall have no further rights under this
Section 7.09. Should Tenant elect to arbitrate by written notice in accordance with the aforesaid clause (iii), and should the arbitration not have been concluded prior to the commencement of the Renewal Term, Tenant shall pay Base Rent to Landlord
during the Renewal Term, including Base Rent adjusted to reflect Fair Market Rent specified in the Renewal Rate Notice. If the amount of Fair Market Rent as determined by arbitration is greater than or less than Landlord’s determination, then
any adjustment required to correct the amount previously paid shall be made by payment by the appropriate party within ten (10) days after such determination of Fair Market Rent. 
  

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 (c) If Tenant rejects the amount claimed by Landlord as Fair Market Rent and elects to arbitrate by
written notice in accordance with clause (iii) of Section 7.09(b) above, and if such dispute cannot be resolved by mutual agreement, the dispute shall be submitted to arbitration. The award rendered in any such arbitration may be entered in any
court having jurisdiction and shall be final and binding between the parties. The arbitration shall be conducted and determined in the City of Redwood City in accordance with the then-prevailing commercial arbitration rules of the American
Arbitration Association or its successor for arbitration of commercial disputes except to the extent that the procedures mandated by said rules shall be modified as follows: 
  
 (i) Tenant shall make demand for arbitration, if at all, in writing in accordance with clause (iii) of Section 7.09(b) above
within thirty (30) days after receipt of the Renewal Rate Notice, specifying therein the name and address of the person to act as the arbitrator on its behalf. The arbitrator shall be qualified as a real estate appraiser familiar with the Fair
Market Rent of high-quality commercial office and laboratory space in central and southern San Mateo County who would qualify as an expert witness over objection to give testimony addressed to the issue in a court of competent jurisdiction. Failure
on the part of Tenant to make a timely and proper demand for such arbitration in accordance with clause (iii) of Section 7.09(b) above shall constitute a waiver of the right thereto. Within ten (10) business days after the service of Tenant’s
timely demand for arbitration, Landlord shall have the right to give notice in writing to Tenant of Landlord’s adjusted determination of Fair Market Rent. Within ten (10) business days following Tenant’s receipt of such notice, if Tenant
and Landlord have not agreed upon Fair Market Rent, Tenant shall notify Landlord in writing that Tenant desires to renew its demand for arbitration. Failure on the part of Tenant to give such notice shall constitute a waiver of the right to such
arbitration, and Tenant shall be deemed to have accepted Landlord’s adjusted determination of Fair Market Rent. Within ten (10) business days after the receipt of a notice to renew Tenant’s demand, Landlord shall give notice to Tenant,
specifying the name and address of the person designated by Landlord to act as arbitrator on its behalf who shall be similarly qualified. If Landlord fails to notify Tenant of the appointment of its arbitrator, within or by the time above specified,
then the arbitrator appointed by Tenant shall be the arbitrator to determine the issue. 
  
 (ii) If two (2) arbitrators are chosen pursuant to subsection (i) above, the arbitrators so chosen shall meet within ten (10) business days after the second arbitrator is appointed and, if within ten (10) business
days after such first meeting the two arbitrators shall be unable to agree promptly upon a determination of Fair Market Rent, they shall appoint a third arbitrator, who shall be a competent and impartial person with qualifications similar to those
required of the first two arbitrators pursuant to subsection (i) above. If they are unable to agree upon such appointment within five (5) business days after expiration of said ten (10) day period, the third arbitrator shall be selected by the
parties themselves, if they can agree thereon, within a further period of ten (10) business days. If the parties do not so agree, then either party, on behalf of both, may request appointment of such a qualified person by the then Chief Judge of the
United States District Court having jurisdiction over the City of Redwood City, acting in his private non-judicial capacity. Request for appointment shall be made in writing with a copy given to the other party. Each party agrees that said Judge
shall have the power to make the 
  

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 appointment; provided, however, that if the Chief Judge does not make a determination within ten (10) days of request by
either party for the appointment of a third arbitrator, appointment of such third arbitrator shall be made in accordance with the selection procedure of the commercial arbitration rules of the American Arbitration Association or its successor for
arbitration of commercial disputes. The three (3) arbitrators shall decide the dispute, if it has not previously been resolved, by following the procedure set forth in subsection (iii) below. 
  
 (iii) Where the issue cannot be resolved by agreement between the two
arbitrators selected by Landlord and Tenant or settlement between the parties during the course of arbitration, the issue shall be resolved by the three arbitrators in accordance with the following procedure. The arbitrators selected by each of the
parties shall state in writing their respective determinations of the Fair Market Rent, supported by the reasons therefor with counterpart copies to each party. The arbitrators shall arrange for a simultaneous exchange of such proposed resolutions.
The role of the third arbitrator shall be to select which of the two proposed resolutions most closely approximates his determination of Fair Market Rent. The third arbitrator shall have no right to propose a middle ground or any modification of
either of the two proposed resolutions. The resolution he chooses as most closely approximating his determination shall constitute the decision of the arbitrators and be final and binding upon the parties. 
  
 (iv) If any arbitrator fails, refuses or is unable to act, his successor
shall be appointed by him, but in the case of the third arbitrator, his successor shall be appointed in the same manner as provided for appointment of the third arbitrator. The arbitrators shall attempt to decide the issue within ten (10) business
days after the appointment of the third arbitrator. Any decision in which the arbitrator appointed by Landlord and the arbitrator appointed by Tenant concur shall be binding and conclusive upon the parties. Each party shall pay the fees and costs of
its own counsel. The losing party shall pay the fees and costs of the arbitrators and of the expert witnesses (if any) of the prevailing party as well as those of its expert witnesses. For purposes hereof, the losing party shall be that party whose
selected arbitrator’s statement of Fair Market Rent was not selected by the third arbitrator. 
  
 (v) The arbitrators shall have the right to consult experts and competent authorities with factual information or evidence pertaining to a determination
of Fair Market Rent, but any such consultation shall be made in the presence of both parties with full right on their part to cross-examine. The arbitrators shall render their decision and award in writing with counterpart copies to each party. The
arbitrators shall have no power to modify the provisions of this Lease. 
  
 7.10 No Waiver. Failure of Landlord or Tenant to declare any default immediately upon occurrence thereof, or delay in taking any action in connection therewith, shall not waive such default, but Landlord or Tenant, as
the case may be, shall have the right to declare any such default at any time thereafter. No waiver by Landlord of an Event of Default, or any agreement, term, covenant or condition contained in this Lease, shall be effective or binding on Landlord
unless made in writing and no such waiver shall be implied from any omission by Landlord to take action with respect to such Event of Default or other such matter. No express written waiver by Landlord of any Event of Default, or other such matter,
shall affect or cover any other Event of Default, matter or period of time, other than the Event of Default, matter and/or period 
  

 45 

 of time specified in such express waiver. One or more written waivers by Landlord of any Event of Default, or other
matter, shall not be deemed to be a waiver of any subsequent Event of Default, or other matter, in the performance of the same provision of this Lease. Acceptance of Rent by Landlord hereunder, or endorsement of any check, shall not, in and of
itself, constitute a waiver of any breach or Event of Default or of any agreement, term, covenant or condition of this Lease, except as to the payment of Rent so accepted, regardless of Landlord’s knowledge of any concurrent Event of Default or
matter. Landlord may, at its election, apply any Rent received from Tenant to the oldest obligation outstanding from Tenant to Landlord, any endorsement or other statement of Tenant to the contrary notwithstanding. No course of conduct between
Landlord and Tenant, and no acceptance of the keys to or possession of the Leased Premises before the termination of the Term by Landlord or any employee of Landlord shall constitute a waiver of any such breach or of any term, covenant or condition
of this Lease or operate as a surrender of this Lease. All of the remedies permitted or available to Landlord under this Lease, or at law or in equity, shall be cumulative and not alternative and invocation of any such right or remedy shall not
constitute a waiver or election of remedies with respect to any other permitted or available right or remedy. 
  
 7.11 Statutory Waivers. Tenant hereby waives the benefits of: (i) Sections 1932 and 1933(4) of the California Civil Code (pertaining to the
termination of a hiring); (ii) 1941 and 1942 of the California Civil Code (pertaining to the obligations of a landlord to maintain premises and the rights of a tenant to make certain repairs or terminate a lease); (iii) Section 1263.260 of the
California Code of Civil Procedure (pertaining to the removal of improvements upon condemnation); and (iv) Section 1265.130 of the California Code of Civil Procedure (pertaining to the termination of a lease upon condemnation). 
  
 7.12 Holding Over. If Tenant holds over after expiration or
termination of this Lease without the written consent of Landlord, Tenant shall pay for each month of hold-over tenancy the greater of (i) one hundred fifty percent (150%) of the Base Rent that Tenant was obligated to pay for the month immediately
preceding the end of the Term, or (ii) one hundred fifty percent (150%) of the market rental amount then applicable to the Leased Premises, as determined by Landlord, for each month or any part thereof of any such hold-over period, together with
payments of Estimated Building Operating Cost and such other amounts as may become due hereunder. No holding over by Tenant after the Term shall operate to extend the Term. If Tenant holds over without consent, Tenant shall indemnify, defend,
protect and hold Landlord and Landlord Parties harmless from and against any and all claims, judgments, damages, penalties, fines, costs, expenses, liabilities or losses for damages by any other tenant or third person to whom Landlord may have
leased or offered to lease all or any part of the Leased Premises covered hereby effective on or after the termination of this Lease, together with all loss, cost, expense, damages and liabilities in connection with any such reletting, including,
without limitation, attorneys’ fees and Landlord’s lost revenues. Any holding over with the consent of Landlord in writing shall thereafter constitute this Lease a lease from month to month. 
  
 7.13 Attorneys’ Fees. If either party places the
enforcement of this Lease, or any part thereof, or the collection of any Rent due, or to become due hereunder, or recovery of the possession of the Leased Premises in the hands of an attorney or collection agency, or files suit upon the same, or
seeks a judicial declaration of rights hereunder, the prevailing party shall recover its reasonable attorneys’ fees, court costs and collection agency charges. As used herein, 
  

 46 

 “prevailing party” shall mean the party who substantially prevails in the matter at issue, including,
without limitation, a party who dismisses an action for recovery hereunder in exchange for payment of the sums allegedly due, performance of covenants allegedly breached or consideration substantially equal to the relief sought in the action.

  
 7.14 Amendments. This Lease may not be altered,
changed or amended, except by an instrument in writing signed by both parties. 
  
 7.15 Transfers By Landlord. Landlord shall have the right to transfer and assign, in whole or in part, all of its rights and obligations hereunder and in the Project. Upon transfer by Landlord of its
interest in the Project, and upon the transferee’s assumption of Landlord’s obligations hereunder, no further liability or obligations shall thereafter accrue against the transferring or assigning person as Landlord hereunder. 

 
 7.16 Severability. If any term or provision of this Lease,
or the application thereof to any person or circumstances, shall to any extent be invalid or unenforceable, the remainder of this Lease, or the application of such provision to persons or circumstances other than those as to which it is invalid or
unenforceable, shall not be affected thereby, and each provision of this Lease shall be valid and shall be enforceable to the extent permitted by law. 
  
 7.17 Notices. All notices, demands, consents and approvals that may or are required to be given by either party to the other hereunder shall
be in writing and shall be deemed to have been fully given (i) when delivered by personal delivery, (ii) two (2) business days after being deposited in the United States mail, certified or registered, postage prepaid, or (iii) one (1) business day
after being deposited with an overnight courier, such as UPS or Federal Express, and addressed to the party to be notified at the address for such party specified on the Basic Lease Information sheet, or to such other place as the party to be
notified may from time to time designate by at least fifteen (15) days’ notice to the notifying party. 
  
 7.18 No Option. Submission of this instrument for examination or signature by Tenant does not constitute a reservation of or an option for
lease, and it is not effective as a lease or otherwise until execution and delivery by both Landlord and Tenant. 
  
 7.19 Integration and Interpretation. The terms of this Lease are intended by the parties as a final expression of their agreement with
respect to such terms as are included in this Lease and may not be contradicted by evidence of any prior or contemporaneous agreement, arrangement, understanding or negotiation (whether oral or written). The parties further intend that this Lease
constitutes the complete and exclusive statement of its terms, and no extrinsic evidence whatsoever may be introduced in any judicial proceeding involving this Lease. The language in all parts of this Lease shall in all cases be construed as a whole
and in accordance with its fair meaning and not restricted for or against any party, regardless of which party may have drafted the provision in question, it being agreed that this is a negotiated agreement. 
  
 7.20 Quitclaim. Upon expiration or earlier termination of this
Lease, Tenant shall, immediately upon request of Landlord, execute, acknowledge and deliver to Landlord a recordable deed quit-claiming to Landlord all interest of Tenant in the Leased Premises, the Project and this Lease. 
  

 47 

 7.21 No Easement For Light, Air and View. This Lease conveys to Tenant no rights for any
light, air or view. No diminution of light, air or view, or any impairment of the visibility of the Leased Premises from inside or outside the Building, by any structure or other object that may hereafter be erected (whether or not by Landlord)
shall entitle Tenant to any reduction of Rent under this Lease, constitute an actual or constructive eviction of Tenant, result in any liability of Landlord to Tenant, or in any other way affect this Lease or Tenant’s obligations hereunder.

  
 7.22 No Merger. The voluntary or other surrender
or termination of this Lease by Tenant, or a mutual cancellation thereof shall not work a merger, but, at Landlord’s sole option, shall either terminate all existing subleases or subtenancies or shall operate as an assignment to Landlord of all
such subleases or subtenancies. 
  
 7.23 Memorandum of
Lease. Tenant shall, upon request of Landlord, execute, acknowledge and deliver a short form memorandum of this Lease (and any amendment hereto or consolidation hereof), in form suitable for recording. In no event shall this Lease or any
memorandum thereof be recorded without the prior written consent of Landlord, which consent shall not be unreasonably withheld, and any attempt to do so shall constitute a default by Tenant. 
  
 7.24 Survival. All of Tenant’s covenants and obligations
contained in this Lease shall survive the expiration or earlier termination of this Lease. No provision of this Lease providing for termination in certain events shall be construed as a limitation or restriction of Landlord’s rights and
remedies at law or in equity available upon a breach by Tenant of this Lease. 
  
 7.25 Financial Statements. From time to time Tenant shall, within fifteen (15) days of Landlord’s written request, furnish Landlord with Tenant’s most recently available financial statements,
which shall be no more than one quarter old, certified as accurate by Tenant or, if available, audited financial statements prepared by an independent certified public accountant with copies of the auditor’s statement. Notwithstanding the
foregoing, if Tenant is a public company, then Tenant shall only be required to provide to Landlord such financial statements as are publicly available. Except to the extent that such financial statements are publicly available, Landlord shall keep
Tenant’s financial statements strictly confidential, provided that Landlord shall be permitted to disclose such financial statements as required by Law and to share such financial statements with its attorneys, advisors, accountants, partners,
lenders and prospective lenders, purchasers and prospective purchasers (as long as Landlord notifies such parties of the confidentiality provisions contained herein and obtains such parties’ written agreement to maintain the confidentiality of
the same, subject to such parties’ right to disclose the same as required by Law). If Landlord provides Tenant’s financial statements to a third party in accordance with the foregoing sentence, Landlord shall notify Tenant of such fact and
shall provide Tenant with a copy of the applicable confidentiality agreement; provided, however, that if Landlord deems the identity of the recipient to be confidential, then Landlord shall not be required to disclose the identity of the recipient
or to furnish a copy of the confidentiality agreement to Tenant until such time as Landlord no longer deems the same to be confidential. Notwithstanding anything herein to the contrary, Tenant shall not be required to deliver financial statements to
Landlord more than once per twelve (12) month period, except in connection with a contemplated sale or financing of the Building or the Project by Landlord. 
  

 48 

 7.26 No Joint Venture. This Lease shall not be construed to create a partnership, joint
venture or similar relationship or arrangement between Landlord and Tenant hereunder. 
  
 7.27 Successors and Assigns. This Lease shall be binding upon and inure to the benefit of Landlord, its successors and assigns (subject to the provisions hereof, including, without limitation, Section
5.16); and shall be binding upon and inure to the benefit of Tenant, its successors, and to the extent assignment may be approved by Landlord hereunder, Tenant’s assigns. 
  
 7.28 Applicable Law. All rights and remedies of Landlord and Tenant under this Lease shall be construed and
enforced according to the laws of the State of California. Any actions or proceedings brought under this Lease, or with respect to any matter arising under or out of this Lease, shall be brought and tried only in courts located in the County of San
Mateo, California (excepting appellate courts). 
  
 7.29
Time of the Essence. Time is of the essence of each and every covenant herein contained. 
  
 7.30 Interpretation. The term, “including” shall mean “including, without limitation.” All indemnities contained herein
shall survive termination of this Lease with respect to any act, condition or event that is the subject matter of such indemnity and that occurs prior to the Term Expiration Date. Notwithstanding anything herein to the contrary, all provisions of
this Lease which require the payment of money or the delivery of property after the Term Expiration Date shall survive termination of this Lease. 
  

	 	7.31	Parking. 

  
 (a) Tenant shall be entitled to the non-preferential and non-exclusive use of two hundred one (201) parking spaces in the Common Areas, for which right
Tenant shall pay any tax or assessment imposed by any governmental authority in connection with the parking privileges provided to Tenant pursuant to this Lease. Said tax or assessment shall be paid in the same manner as Additional Rent hereunder,
regardless of whether or not Tenant uses said spaces. Landlord may assign any unreserved and unassigned parking spaces and/or make all or a portion of such spaces reserved, if it determines that it is necessary for orderly and efficient parking.
Landlord shall have the right, at any time, to relocate Tenant’s parking to other areas within the Project and to provide parking spaces to Tenant in surface parking lots, parking structures or other areas now or hereafter designated by
Landlord as the “Project’s Parking Areas,” provided that Landlord shall only do so on a nondiscriminatory basis (i.e., vis-à-vis other tenants of the Project). 
  
 (b) Notwithstanding the terms of Section 7.31(a) above, two (2) spaces (out
of the total of 201 spaces) shall be reserved (the “Reserved Spaces”) throughout the Term, and shall be located immediately adjacent to Tenant’s loading dock. Landlord shall not be responsible for the enforcement of
Tenant’s reserved parking rights in the Reserved Spaces. 
  
 7.32 Brokers. Tenant and Landlord each represent and warrant to the other that it has had no dealing with any broker or agent other than the Broker set forth on the Basic Lease Information. Tenant and Landlord each indemnify,
defend and hold the other party harmless 
  

 49 

 from and against any and all liabilities for commissions or other compensation or charges claimed by any other broker or
agent based on dealings with the indemnifying party with respect to this Lease. The foregoing indemnity shall survive termination or earlier expiration of this Lease. 
  
 7.33 Reasonable Expenditures. Any expenditure by a party permitted or required under this Lease, for which
such party is entitled to demand and does demand reimbursement from the other party, shall be reasonably incurred, and shall be substantiated by documentary evidence available for inspection and review by the other party or its representative during
normal business hours. The terms of this Section 7.33 shall not apply to the payment of Gross Rent by Tenant, which shall be governed solely by the terms of Article 3 above. 
  
 7.34 Right to Cure. In the event that Landlord fails to perform a material obligation of Landlord under this
Lease, Tenant shall provide written notice of such failure to Landlord. Landlord shall have thirty (30) days after receipt of such notice to cure such failure (or, if Landlord can not reasonably cure such failure within such thirty (30) day period,
such additional time as Landlord reasonably requires to cure the same). If Landlord fails to cure such failure within the aforesaid thirty (30) day (or, if applicable, longer) period, and if such failure on the part of Landlord results in a material
interference with Tenant’s ability to conduct its business operations in the Leased Premises, then Tenant shall have the right to take such actions as may be reasonably required to cure such failure. Landlord shall reimburse Tenant for the
reasonable costs incurred by Tenant in effectuating a cure in accordance with this Section 7.34. In the event Tenant performs an action under this Section 7.34, then Tenant shall hold harmless and indemnify Landlord and Landlord’s Agents from
and against all liabilities, damages, claims, losses, penalties, judgments, charges and expenses (including attorneys’ fees, costs of court and expenses necessary in the prosecution or defense of any litigation including the enforcement of this
provision) arising from or in any way related to, directly or indirectly, Tenant’s or Tenant’s Agents’ acts, including, without limitation, any costs incurred in repairing or replacing any defective or faulty construction performed by
Tenant or Tenant’s Agents. 
  
 7.35 Approvals.
Whenever this Lease requires an approval, consent, designation, determination, selection or judgment by either Landlord or Tenant, except as otherwise specifically set forth in this Lease, such approval, consent, designation, determination,
selection or judgment and any conditions imposed thereby shall be reasonable and shall not be unreasonably withheld or delayed and, in exercising any right or remedy hereunder, each party shall at all times act reasonably and in good faith.

  

 50 

 IN WITNESS WHEREOF, the parties hereto have executed this
Lease as of the day and year first above written. 
  

																			
	 	 	 	 	 LANDLORD:
	  	 WOODSIDE TECHNOLOGY CENTER, LLC,
 a Delaware limited liability company

					
	 	 	 	 	 	  	By:	 	 National Office Partners Limited Partnership,
 a Delaware limited partnership,
 its sole member

						
	 	 	 	 	 	  	 	 	By:	 	 Hines National Office Partners Limited Partnership,
 a Texas limited partnership,
 its general partner

							
	 	 	 	 	 	  	 	 	 	 	By:	 	 Hines Fund Management, L.L.C.,
 a Delaware
limited liability company,
 its general partner

								
	 	 	 	 	 	  	 	 	 	 	 	 	By:	 	 Hines Interests Limited Partnership,
 a Delaware limited partnership
 its sole member

									
	 	 	 	 	 	  	 	 	 	 	 	 	 	 	By:	 	 Hines Holdings, Inc.,
 a Texas
corporation,
 its general partner

										
	 	 	 	 	 	  	 	 	 	 	 	 	 	 	 	 	By:	 	 /s/ James C. Buie, Jr.

										
	 	 	 	 	 	  	 	 	 	 	 	 	 	 	 	 	Its:	 	 Executive Vice Pres.

	 	 	 	 	 	  	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	 TENANT:
	  	 FOXHOLLOW TECHNOLOGIES, INC.,
 a Delaware corporation

					
	 	 	 	 	 	  	By:	 	 /s/ Robert W. Thomas

	 	 	 	 	 	  	Name:	 	 Robert W. Thomas

	 	 	 	 	 	  	Title:	 	 President & CEO

  

 51 

 EXHIBIT A 
  
 “Leased Premises Depiction” 
  
 

 
  

 A-1 

 EXHIBIT B 
  
 “Project Legal Description” 
  
 The land referred to herein is located in the State of California, County of San Mateo, and is described as follows:

  
 Parcels 1, 2 and 3, as shown on that certain map entitled
“Parcel Map No. 97-6, lying entirely within the City of Redwood City, California”, filed in the office of the County Recorder of San Mateo County, State of California, on December 10, 1997 in Book 70 of Parcel Maps at page(s) 17 and
18. 
  

 B-1 

 EXHIBIT C 
  
 Lease Commencement Certificate 
  
 Sample Form of 
 Lease Commencement Certificate

  
 OFFICE BUILDING 
  

	Re:	Woodside Technology Center, LLC 

	 	740 Bay Road 

	 	Redwood City, California 94085 

  

	 	This is to certify that [Tenant’s Name and Suite Number] has opened/closed on [Date] 

  

	 	Leased Premises Rentable Square
Feet:                                       
       

  

	 	Lease Commencement
Date:                                       
                          

  

	 	Lease Expiration
Date:                                       
                                    

  

	 	Rental Payment Commencement
Date:                                       
        

  

	 	Final Tenant Construction
Overage:                                      
            

  

	 	Insurance Certificate submitted
(Y/N):                                       
       

  

	 	_______________________________________________ , 

  

	 	a                                      
                                        
                                

  

	 	By:
                                        
                                        
                         

	 	Name:
                                        
                                        
                    

	 	Its:
                                        
                                        
                         

  

 C-1 

 EXHIBIT D 
  
 Tenant Improvements 
  
 Initial Improvement of the Leased Premises 
  
 1. Improvements. Following the mutual execution and delivery of the Lease, Tenant shall construct certain improvements (the “Tenant
Improvements”) within the Leased Premises substantially in accordance with plans and specifications to be prepared by the Architect (as hereafter defined) and approved by Landlord in accordance with this Exhibit D. Subject
only to Landlord’s Contribution (as hereafter defined), the Tenant Improvements shall be designed, furnished and installed at the sole cost and expense of Tenant. For purposes hereof, the cost of the Tenant Improvements (the “Tenant
Improvements Cost”) shall include all costs and expenses of any nature whatsoever associated with the design and construction of the Tenant Improvements, including, without limitation, all building permit fees, payments to design
consultants for services and disbursements (including, without limitation, all costs of the “Conceptual Plans” and the “Working Drawings,” as such terms are hereinafter defined), all demolition and other preparatory work,
premiums for insurance and bonds, general conditions, and the cost of installing any additional electrical, mechanical or telecommunications capacity required by Tenant. Notwithstanding anything to the contrary herein or in the Lease, Landlord, at
its sole cost and expense shall be responsible for, and Landlord’s Contribution shall not be used for, the following: (a) costs resulting from the removal of Hazardous Materials on, in or under the Leased Premises; provided, however, that the
removal of such Hazardous Materials is required by governmental authorities and Tenant is unable to make reasonable modifications to the design of the Tenant Improvements in order to eliminate the need to remove the Hazardous Materials; and (b)
Landlord’s supervision costs. 
  
 2. Tenant’s
Architect, Engineers and Contractors. Tenant shall select architects, engineers and contractors from a list of approved architects, engineers and contractors to be provided to Tenant by Landlord. In the event that Tenant desires to use an
architect, engineer or contractor not on the list provided by Landlord, Tenant may request the consent of Landlord to the use of such architect, engineer or contractor, which consent shall not be unreasonably withheld. The architect and general
contractor selected for the Tenant Improvements in accordance with this Exhibit D shall each be licensed in the State of California and shall be herein referred to as the “Architect” and the
“Contractor,” respectively. The cost of preparing all plans and specifications for the Tenant Improvements (including, without limitation, the Conceptual Plans referred to in Paragraph 3 of this Exhibit D and the
Working Drawings referred to in Paragraph 4 of this Exhibit D), and the cost of preparing any change thereto shall be included in the Tenant Improvements Cost. 
  
 3. Submittal of Conceptual Plans. 
  
 (a) Tenant shall cause the Architect to prepare conceptual plans for the Tenant Improvements (the “Conceptual
Plans”), including architectural, electrical and reflected ceiling drawings, within thirty (30) days after the mutual execution and delivery of the Lease. Such Conceptual Plans shall be for the general information of Landlord, and to assist
in the coordination of the design and construction of the Tenant Improvements, but receipt of such 
  

 D-1 

 Conceptual Plans by Landlord shall not constitute an approval by Landlord of the design or specifications shown thereon.
Landlord shall, within seven (7) days following receipt by Landlord of such plans, review, comment on and return the Conceptual Plans to Tenant, marked “Approved,” “Approved as Noted” or “Disapproved as Noted, Revise and
Resubmit.” If the Conceptual Plans are returned to Tenant and the Architect marked “Approved,” the Conceptual Plans shall be deemed approved by Landlord and the procedure set forth in Paragraph 4 below shall be followed. If the
Conceptual Plans are returned to Tenant and the Architect marked “Approved as Noted,” the Conceptual Plans so submitted shall be deemed approved by Landlord and the procedure set forth in Paragraph 4 below shall be followed; provided,
however, that in preparing the Working Drawings, Tenant shall cause the Architect to incorporate Landlord’s noted items into the Working Drawings or an alternate proposal made by Tenant for Landlord’s consideration. If the Conceptual Plans
are returned to Tenant marked “Disapproved as Noted, Revise and Resubmit,” Tenant shall cause such plans to be revised, taking into account the reasons for Landlord’s disapproval, and shall resubmit revised plans to Landlord for
review within ten (10) days after return of the Conceptual Plans to Tenant by Landlord. The same procedure shall be repeated until Landlord fully approves the Conceptual Plans. Landlord shall not unreasonably withhold such approval. 
  
 (b) In the event Landlord fails to approve or provide comments on the
Conceptual Plans within seven (7) days as contemplated under Paragraph 3(a) above, then Tenant shall provide a second written notice to Landlord requesting such response. The notice shall contain the words “FAILURE
TO RESPOND WITHIN FIVE (5) BUSINESS DAYS SHALL CAUSE YOU TO LOSE
VALUABLE LEGAL RIGHTS” in 14-point bold print at the top thereof. If Landlord fails to respond to Tenant within five (5) business days after Landlord’s receipt of such second notice, then
Landlord shall be deemed to have approved the Conceptual Plans. 
  
 4. Submittal of Working Drawings. 
  
 (a)
Tenant shall instruct the Architect to deliver to Landlord, within thirty (30) days after the approval by Landlord of the Conceptual Plans, three (3) sets of blue-lined prints of working drawings and specifications (hereinafter referred to
collectively as the “Working Drawings”) for the Tenant Improvements. Tenant shall cooperate with Landlord and the Architect and shall promptly provide such information as may be requested by Landlord and the Architect in order to
complete the Working Drawings on a timely basis. If the draft of the Working Drawings was prepared on a computer-assisted design system, Tenant shall cause the Architect to deliver to Landlord a copy of such Working Drawings in electronic format
compatible with Landlord’s architect’s AutoCAD standards together with a copy of such Working Drawings on diskette in the AutoCAD format or such other format as may then be in common use for computer assisted design purposes. Within ten
(10) days of the receipt by Landlord of a draft of Working Drawings from Tenant, Landlord shall return to Tenant one (1) sepia set of the Working Drawings marked “Approved,” “Approved as Noted” or “Disapproved as Noted,
Revise and Resubmit.” If the Working Drawings are returned to Tenant marked “Approved,” the Working Drawings, as so submitted, shall be deemed approved by Landlord. If the Working Drawings are returned to Tenant marked “Approved
as Noted,” the draft of the Working Drawings shall be deemed approved by Landlord; provided, however, that in preparing the final approved Working Drawings, Tenant shall cause the Architect to incorporate Landlord’s noted items into the
Working Drawings or an alternate proposal made by Tenant for 
  

 D-2 

 Landlord’s consideration. If the Working Drawings are returned to Tenant marked “Disapproved as Noted, Revise
and Resubmit,” Tenant shall cause such Working Drawings to be revised, taking into account the reasons for Landlord’s disapproval and shall resubmit revised plans to Landlord for review. The same procedure shall be repeated until Landlord
fully approves the Working Drawings. Landlord shall not unreasonably withhold such approval. The Working Drawings shall be consistent with, and a logical extension of, the Conceptual Plans approved by Landlord in accordance with Paragraph 3 of this
Exhibit D. Tenant shall be solely responsible for: (i) the completeness of the Working Drawings; (ii) the conformity of the Working Drawings with the existing conditions in the Building and the Leased Premises; (iii) the compatibility
of the Working Drawings with the shell or the core or the mechanical, plumbing, life safety or electrical systems of the Building (and Tenant shall obtain mechanical and electrical drawings from Landlord, the cost of which shall be included in the
Tenant Improvements Cost); and (iv) the compliance of the Working Drawings with all applicable Laws, including, without limitation, the Americans With Disabilities Act. When the Working Drawings are approved by Landlord and Tenant, they shall be
acknowledged as such by Landlord and Tenant signing each sheet of the Working Drawings. If the Working Drawings were prepared on a computer-assisted design system, Tenant shall cause the Architect to deliver to Landlord a copy of such Working
Drawings in electronic format compatible with Landlord’s architect’s AutoCAD standards, together with a copy of such Working Drawings on diskette in the AutoCAD format or such other format as may then be in common use for computer assisted
design purposes. 
  
 (b) In the event Landlord fails to approve or
provide comments on the Working Drawings within ten (10) days as contemplated under Paragraph 4(a) above, then Tenant shall provide a second written notice to Landlord requesting such response. The notice shall contain the words
“FAILURE TO RESPOND WITHIN FIVE (5) BUSINESS DAYS SHALL CAUSE YOU TO
LOSE VALUABLE LEGAL RIGHTS” in 14-point bold print at the top thereof. If Landlord fails to respond to Tenant within five (5) business days after Landlord’s receipt of such second
notice, then Landlord shall be deemed to have approved the Working Drawings. 
  
 5. Landlord’s Review Responsibilities. Tenant acknowledges and agrees that Landlord’s review and approval, if granted, of all Conceptual Plans and Working Drawings is solely for the benefit of
Landlord and to protect the interests of Landlord in the Building and the Leased Premises, and Landlord shall not be the guarantor of, nor in any way or to any extent responsible for, the correctness or accuracy of any Conceptual Plans or Working
Drawings or of the compliance of the Conceptual Plans or Working Drawings with applicable Laws or of the conformance or compatibility of the Conceptual Plans or Working Drawings with existing conditions in the Building or Leased Premises or with the
shell or the core or the mechanical, plumbing, life safety or electrical systems of the Building. Tenant shall require and be solely responsible for ensuring that the Architect and all engineers and contractors verify all existing conditions in the
Building, insofar as they are relevant to, or may affect, the design and construction of the Tenant Improvements, and Landlord shall have no liability to Tenant for any inaccuracy or incorrectness in any of the information supplied by Landlord with
regard to existing conditions. Tenant shall be solely responsible for, and Landlord specifically reserves the right to require the Architect to make at any time and from time to time during the construction of the Tenant Improvements, any reasonable
changes to the Conceptual Plans and the Working Drawings reasonably necessary to obtain any permit or to comply with all 
  

 D-3 

 applicable Laws or to achieve the compatibility, as reasonably determined by Landlord, of the Conceptual Plans and
Working Drawings with the shell and the core and the mechanical, plumbing, life safety and electrical systems of the Building and any third-party warranties. 
  
 6. Tenant’s Contractor. Landlord shall have the right in its reasonable discretion to approve the general contractor ultimately
selected for the Tenant Improvements, and such party shall be the “Contractor” hereunder. 
  
 7. Administration of Work. 
  
 (a) After acceptance of bids, Tenant shall cause the Contractor to construct and install the Tenant Improvements in strict accordance with the Working
Drawings. Tenant shall not authorize or permit the Contractor to install any Tenant Improvements that do not conform to the approved Working Drawings, or conflict with elements of the approved Working Drawings, or do not comply with applicable Laws,
such conformity being the obligation of Tenant. 
  
 (b) All Tenant
Improvements shall be constructed by the Contractor or subcontractors selected for the work. Tenant and Contractor shall have the right to select the subcontractors for the work; provided, however, that Landlord shall have the right to approve in
writing in its reasonable discretion the mechanical, electrical, plumbing and data/telephone subcontractors. 
  
 (c) The Contractor and all subcontractors and materialmen shall be subject to the rules of the site. Contractors, subcontractors and materialmen engaged
by Tenant shall take the necessary steps to insure, so far as may be possible, the progress of the work without interruption on account of strikes, work stoppage or similar causes for delay. In the event that Tenant’s contractors or
subcontractors do not promptly cause any pickets to be withdrawn and all other disruptions to the operations of the Building promptly to cease, or in the event that Landlord notifies Tenant that Landlord has in good faith concluded that picketing or
other disruptive activities are an imminent threat, Tenant shall immediately cause the withdrawal from the job of all its contractors, subcontractors or materialmen involved in the dispute. 
  
 (d) Tenant shall require that each of its contractors, subcontractors and
materialmen maintain commercial general liability insurance in an amount of not less than Two Million Dollars ($2,000,000.00) per occurrence on a combined single limit basis and all worker’s compensation insurance required by law. 

 
 (e) Landlord shall provide access and entry to the Leased Premises to
Tenant following the mutual execution and delivery of the Lease by the parties hereto to allow Tenant to proceed with the construction and installation of the Tenant Improvements. Upon and following any entry into the Leased Premises by Tenant prior
to the commencement of its Term, Tenant shall perform all of the obligations of Tenant applicable under the Lease during the Term (except the obligation to pay Base Rent and Basic Operating Cost), including, without limitation, obligations
pertaining to insurance, indemnity, compliance with Laws, and Hazardous Materials. In addition to the indemnity obligations of Tenant under the Lease, Tenant shall indemnify, defend and protect Landlord and hold Landlord harmless of and from any and
all claims, 
  

 D-4 

 proceedings, loss, cost, damage, causes of action, liabilities, injury or expense arising out of or related to claims of
injury to or death of persons or damage to property occurring or resulting directly or indirectly from the presence in the Leased Premises or the Project of Tenant’s contractors or representatives or the activities of Tenant or its contractors
or representatives in or about the Leased Premises or Project during the construction period, such indemnity to include, but without limitation, the obligation to provide all costs of defense against any such claims. This indemnity shall survive the
expiration or sooner termination of the Lease. 
  
 (f) After the
Conceptual Plans or Working Drawings have been approved by Landlord as provided above, Tenant may make changes thereto with Landlord’s prior written approval, which approval shall not be unreasonably withheld or delayed; provided, however, that
such changes shall be consistent with the preapproved preliminary plans. Landlord shall approve or reasonably disapprove of any such requested change within three (3) business days (or, if the cost to design and construct the change or any related
changes would exceed Fifty Thousand Dollars ($50,000.00), five (5) business days) of request for approval therefor. 
  
 8. Obligation of Tenant To Provide As-Built Plans. Within ninety (90) days after Substantial Completion, Tenant shall cause the Architect to
provide to Landlord a complete set of plans and specifications reflecting the actual conditions of the Tenant Improvements as constructed in the Leased Premises, together with a copy of such plans in electronic format compatible with Landlord’s
architect’s AutoCAD standards and a copy of such plans on diskette in the AutoCAD format or such other format as may then be in common use for computer assisted design purposes. The costs of the foregoing plans and specifications shall be
included within the Tenant Improvements Cost. 
  
 9.
Reimbursement and Compensation. Landlord shall be entitled to reimbursement for all reasonable costs incurred by Landlord in connection with the design and review of Conceptual Plans and Working Drawings. Landlord will submit invoices
for such costs, with reasonable supporting detail. Landlord may obtain any reimbursement or compensation required hereunder by deducting the amount of such reimbursement or compensation from Landlord’s Contribution. 
  
 10. Landlord’s Contribution. 
  
 (a) Landlord shall provide a total of up to Six Hundred Nine Thousand Eight
Hundred Fifty Dollars ($609,850.00) (“Landlord’s Contribution”), as provided in this Paragraph 10, toward the Tenant Improvements Cost; provided, however, that in no event shall Landlord’s Contribution be available to pay
any project management fees or the costs of Tenant’s Personal Property or any moving costs incurred by Tenant in moving to the Leased Premises. Landlord’s Contribution shall be available to Tenant for a period of twenty-four (24) months
after the date of this Lease. Any portion of Landlord’s Contribution that has not been disbursed to Tenant prior to the expiration of such period shall no longer be available to Tenant. In the event the Tenant Improvements Cost shall be less
than the amount of Landlord’s Contribution, then Landlord’s Contribution shall be reduced to an amount equal to the Tenant Improvements Cost. 
  

 D-5 

 (b) Landlord shall disburse Landlord’s Contribution to Tenant, up to the amount of the Tenant
Improvements Cost, in installments no more than once per month, within thirty (30) days of Landlord’s receipt of a written invoice from Tenant evidencing the actual costs incurred by Tenant to date and such documentation as Landlord may
reasonably require to substantiate the completion of the Tenant Improvements for which such disbursement is requested in a lien-free manner and in accordance with all applicable Laws and the requirements of this Exhibit D. 

 
 (c) The obligation of Landlord to make any one or more payments pursuant
to the provisions of this Paragraph 10 or to authorize Tenant to proceed with the construction of the Tenant Improvements shall be suspended without further act of the parties during any such time as there exists an Event of Default under the Lease
or any event or condition which, with the passage of time or the giving of notice or both would constitute such an Event of Default. Upon the occurrence and during the pendency of an Event of Default or such an event or condition, Landlord shall
have the right, in addition to all other rights and remedies provided in the Lease, at law and in equity, to order that Tenant cease the construction and installation of the Tenant Improvements hereunder. Nothing in this Paragraph 10 shall affect
the obligations of Tenant under the Lease with respect to any alterations, additions and improvements within the Leased Premises, including, without limitation, any obligation to obtain the prior written consent of Landlord hereto. 
  
 (d) If Landlord fails to make a progress payment on a timely basis when
required under Paragraph 10(b) above, Tenant shall provide written notice of such failure to Landlord. Landlord shall have a period of ten (10) days to cure such failure by making the required progress payment. If Landlord fails to cure such default
within the aforesaid ten (10) day period, and provided that (A) Landlord has not raised any objections to the construction of the Tenant Improvements or the obligation of Landlord to then fund the applicable progress payment, and (B) neither an
Event of Default nor an event or condition which, with the passage of time or the giving of notice or both, would constitute and Event of Default, is then occurring hereunder, Tenant may advance such payment on behalf of Landlord and thereafter
deduct the same from the Gross Rent next payable to Landlord hereunder. 
  
 11. Tenant Improvements Loan. In addition to Landlord’s Contribution, at Tenant’s election in writing prior to completion of the Tenant Improvements and at Tenant’s sole discretion, Landlord agrees to loan to
Tenant up to Three Hundred Four Thousand Nine Hundred Twenty-Five Dollars ($304,925.00) to be applied toward the Tenant Improvements Cost (the “Tenant Improvements Loan”); provided, however, that in no event shall the Tenant
Improvements Loan be available to pay the costs of Tenant’s Personal Property or any moving costs incurred by Tenant in moving to the Leased Premises. The Tenant Improvements Loan shall be disbursed following disbursement of Landlord’s
Contribution and in the same manner as Landlord’s Contribution. The Tenant Improvements Loan shall be repayable by Tenant to Landlord in monthly installments equal to ten cents ($0.10) per rentable square foot per month, which installments
shall be deemed “Additional Rent” under the Lease and shall be payable concurrently with the monthly installments of Base Rent. Promptly following the completion of the Tenant Improvements and the calculation of the actual Tenant
Improvements Loan, Landlord and Tenant shall execute a Tenant Improvements Loan Amortization Memorandum in the form attached to the Lease as Exhibit G. Notwithstanding anything herein to the contrary, in the event 
  

 D-6 

 the Lease shall terminate for any reason prior to the scheduled expiration thereof, the unamortized portion of the Tenant
Improvements Loan and all accrued and unpaid interest thereon (calculated at the rate of seventeen percent (17%) per annum) shall immediately become due and payable in full. For purposes of the preceding sentence, the Tenant Improvements Loan shall
be amortized on a straight-line basis over the initial Term of the Lease. 
  
 12. Removal of Tenant Improvements. Landlord shall, in connection with Landlord’s review and approval of the Working Drawings, indicate in writing whether or not the Tenant Improvements or any
portion thereof shall be required to be removed at the expiration or termination of the Term. The Tenant Improvements so required by Landlord to be removed shall be removed by Tenant in accordance with Section 5.19 of the Lease. 
  
 13. Designation of Tenant’s and Landlord’s
Representatives. Tenant hereby designates Ray Johnson as its representative in connection with the design and construction of the Tenant Improvements, and Landlord shall be entitled to rely upon the decisions and agreements made by such
representative as binding upon Tenant. Landlord hereby designates
                                        
     as its representative in connection with the design and construction of the Tenant Improvements, and Tenant shall be entitled to rely upon the decisions and agreements made by such representative as binding upon Landlord.

  

 D-7 

 EXHIBIT E 
  
 Definition of Building Standard Improvements 
  
 For the purposes of the definition set forth in Section 1.06 of the Lease, Building Standard Improvements would consist of:

  

	A.	Partitions. 

  
 One (1) linear foot of ceiling-height partition per twelve (12) rentable square feet less Common Areas. Partitions to be constructed of 2 1/2” metal studs at 24” on center,  5/8” gypsum wallboard both sides, with two coats of latex paint. 
  

	B.	Doors and Hardware. 

  
 One (1) ten (10) foot high, solid core, plain sliced maple door with a clear anodized aluminum frame and polished chrome lever handle latch set hardware
per three hundred (300) rentable square feet less Common Areas. 
  

	C.	Ceiling. 

  
 Suspended metal “T-Bar” ceiling system with 24” × 24” ×  5/8” thick tegular-style mineral fiber acoustical ceiling. 
  

	D.	Lighting. 

  
 One (1) 2’ × 4’ recessed fluorescent lighting fixture with anodized aluminum parabolic shaped louvers, including initial lamping, per
seventy-five (75) rentable square feet less Common Areas, or equivalent lighting as determined by Landlord in its good faith discretion. Common Areas on all office floors shall have lighting selected by Landlord. 
  

	E.	Electrical Outlets. 

  
 One (1) duplex wall-mounted convenience outlet mounted at standard locations with white plastic cover plate for each one hundred twenty (120) rentable
square feet less Common Areas. 
  

	F.	Telephone Outlets. 

  
 One (1) telephone wall outlet mounted at standard locations for each two hundred ten (210) rentable square feet less Common Areas with pull wire through
the partition. 
  

	G.	Floor Covering. 

  
 Direct glue down carpet or a credit of $15.00 per square yard of carpeted area. 
  

 E-1 

	H.	Switch. 

  
 One (1) dual light switch, rocker type, mounted at standard locations with white plastic cover plate for each three hundred (300) rentable square feet
less Common Areas. 
  

	I.	Window Covering. 

  
 Horizontal aluminum one-inch-slat blinds for exterior windows. 
  

	J.	Life Safety Systems. 

  
 Rapid Response fire sprinkler heads to conform with typical Tenant partition layout, utilizing the Building Standard partition and lighting, for light
hazard occupancy design criteria. Manual fire alarm pull stations, exit lights, and audible fire alarm speakers shall be provided at the Building stair doors and elevator lobbies. 
  

	K.	HVAC. 

  
 The HVAC system for the Leased Premises to suit normal general office space utilizing the Building Standard lighting fixtures. 
  
 Landlord and Tenant acknowledge that this list is not exhaustive of all
improvements which now or hereinafter may be located within the Leased Premises, the Building and/or the Project and that this Exhibit E is included as a representative sampling of the scope and quality of the standard improvements
selected for the Project. Notwithstanding the foregoing, the inclusion of this Exhibit E is not a representation or warranty by Landlord regarding the quality, quantity and/or nature of the improvements located within the Leased
Premises or of the operating order, condition and/or repair of such improvements. Tenant acknowledges and agrees that Landlord’s entire obligation with respect to the condition of the improvements located within the Leased Premises shall be as
stated in Section 6.01 of the Lease. 
  

 E-2 

 EXHIBIT F 
  
 Building Rules and Regulations 
  

	1.	Sidewalks, doorways (and, during any period of the Term in which Tenant is not leasing the entire Building from Landlord, halls, stairways and vestibules) and other similar areas
shall not be obstructed by Tenant or used by Tenant for any purpose other than ingress to and egress from the Leased Premises. For purposes of this Exhibit F, the Building shall be deemed to be a “Multi-Tenant
Building” during any period of the Term in which Tenant is not leasing the entire Building from Landlord, as described in Section 3.05(b) of the Lease. 

  

	2.	Plumbing fixtures shall be used only for their designated purpose, and no foreign substances of any kind shall be deposited therein. Damage to any such fixture resulting from misuse
by Tenant or any employee or invitee of Tenant shall be repaired at the expense of Tenant. 

  

	3.	Tenant shall not use any method of heating or air conditioning other than that approved by Landlord without the prior written consent of Landlord, which consent shall not be
unreasonably withheld. 

  

	4.	All window coverings installed by Tenant and visible from the outside of the Building require the prior written approval of Landlord. 

  

	5.	Nails, screws and other attachments to the Building that could affect the structural integrity of the Building require prior written consent from Landlord. Tenant shall remove all
nails, screws and other attachments, patch the walls and repair any related damage to the Building upon the expiration or sooner termination of the Lease. 

  

	6.	During any period that the Building is a Multi-Tenant Building, subject to Section 5.18 of the Lease, Tenant shall not use, keep or permit to be used or kept any foul or noxious gas
or substance or any flammable or combustible materials on or around the Leased Premises. During any period that the Building is not a Multi-Tenant Building, Tenant shall not use, keep or permit to be used or kept any foul or noxious gas or substance
that permeates to and/or can be smelled on the exterior of the Building or that could be harmful to occupants of or visitors to the Project. Nothing contained in this Paragraph 6 shall be deemed or construed to permit Tenant to bring upon or use in
or about the Leased Premises any substance or material that constitutes a Hazardous Material other than in strict compliance with the terms of Section 5.18 of the Lease. 

  

	7.	Tenant shall park motor vehicles in the areas of the Project designated by Landlord as parking areas, including areas for loading and unloading. During those periods of loading and
unloading, Tenant shall not unreasonably interfere with traffic flow around the Building or the Project and loading and unloading areas of other tenants. 

  

	8.	Tenant will operate the Building’s heating and air conditioning systems in a reasonable manner and shall comply with any governmental energy-saving rules or regulations about
which Tenant has been given notice. During any period that the Building is a Multi-Tenant Building, Tenant shall not waste electricity, water or air conditioning, except for any such utilities that are separately metered to Tenant’s Leased
Premises. 

  

 F-1 

	9.	During any period that the Building is a Multi-Tenant Building, canvassing, peddling, soliciting, and distribution of handbills in the Building are prohibited and Tenant will
cooperate to prevent these activities. 

  

	10.	During any period that the Building is a Multi-Tenant Building, Tenant shall not access the roof without Landlord’s permission. 

  

	11.	During any period that the Building is a Multi-Tenant Building, business machines and mechanical equipment belonging to Tenant which cause noise or vibration that may be transmitted
to the structure of the Building, to such a degree as to be reasonably objectionable to Landlord or other tenants, shall be placed and maintained by Tenant, at Tenant’s expense, on vibration isolators or in noise-damping housing or other
devices sufficient to eliminate unreasonable noise or vibration. During any period that the Building is not a Multi-Tenant Building, business machines and mechanical equipment belonging to Tenant which cause noise that can be heard on the exterior
of the Building or vibration that may be transmitted to the structure of the Building, to such a degree as to be reasonably objectionable to Landlord, shall be placed and maintained by Tenant, at Tenant’s expense, on vibration isolators or in
noise-damping housing or other devices sufficient to eliminate unreasonable noise or vibration. Without limiting Landlord’s right to assert that noise is unreasonable in other instances, noise shall be presumed to be unreasonable if it can be
heard inside other buildings at the Project. 

  

	12.	All goods, including material used to store goods, delivered to the Leased Premises of Tenant shall be moved into the Leased Premises within a reasonable time on the date of
delivery and shall not be left in parking or receiving areas overnight. 

  

	13.	Tenant is responsible for the storage and removal of all trash and refuse. All such trash and refuse shall be contained in suitable receptacles stored behind screened enclosures at
locations approved by Landlord. 

  

	14.	Tenant shall not store or permit the storage or placement of goods or merchandise in or around the Common Areas surrounding the Leased Premises, except that goods involved in the
loading and unloading of shipments and receiving of deliveries may be placed in the area of the parking lot immediately adjacent to the loading dock door during staging of such shipping and receiving. No such materials may be left to remain outside
the Building overnight. No displays or sales of merchandise shall be allowed in the parking lots or other Common Areas. 

  

	15.	Tenant shall not permit any animals, including, but not limited to, any household pets (excluding only seeing-eye dogs), to be kept in or about the Leased Premises, the Building,
the Project or any of the Common Areas. 

  

	16.	No smoking shall be permitted in public areas of the Building including, without limitation, lobbies, restrooms, balconies, stairwells and fire exist corridors.

  

	17.	During any period that the Building is a Multi-Tenant Building, movement into or out of the Building of furniture, office equipment, or other bulky material which requires the use
of elevators, stairways, or Building entrance and lobby shall be restricted to hours established 

  

 F-2 

	    	by Landlord, and all such movement shall be under Landlord’s supervision. During any period that the Building is a Multi-Tenant Building, rearrangements with Landlord shall be
made regarding the time, method, and routing of such movement. 

  

	    	At all times (i.e., irrespective of whether the Building is a Multi-Tenant Building), Tenant shall assume all risks of damage and pay the cost of repairing or providing
compensation for damage to the Building, to articles moved and injury to persons or public resulting from such moves. Landlord shall not be liable for any acts or damages resulting from any such activity. Tenant is responsible for ensuring that the
moving/delivery company provides a valid Certificate of Insurance to Landlord. 

  

	18.	During any period that the Building is a Multi-Tenant Building, corridor doors, when not in use, shall be kept closed. 

  

	19.	During any period that the Building is a Multi-Tenant Building, deliveries of water, soft drinks, newspapers, or other such items to the Leased Premises shall be restricted to hours
established by Landlord and made by use of the freight elevators if Landlord so directs. 

  

	20.	During any period that the Building is a Multi-Tenant Building, nothing shall be swept or thrown into the corridors, halls, elevator shafts, or stairways. During any period that the
Building is not a Multi-Tenant Building, nothing shall be swept or thrown into the elevator shafts. No birds, fish, or animals of any kind shall be brought into or kept in, on or about the Leased Premises. 

  

	21.	No cooking shall be done in the Leased Premises except in connection with convenience lunch room or beverage service for employees and guests (on a non-commercial basis) in a manner
which complies with all of the provisions of the Lease and which does not produce fumes or odors. Tenant shall have the right to have outdoor barbecues from time to time upon five (5) business days’ advance written notice to Landlord, subject
to Landlord’s reasonable approval of the location of the same to ensure that Tenant will not interfere with the business operations or rights of other tenants of the Project. Tenant will not play loud music or otherwise disturb other tenants in
connection with such barbecues. 

  

	22.	Except to the extent that the same constitutes a Hazardous Material and is used in compliance with Section 5.18 of the Lease, Tenant shall not use or keep on the Leased Premises any
kerosene, gasoline, or inflammable or combustible fluid or material other than limited quantities reasonably necessary for the operation and maintenance of office equipment. 

  

	23.	Landlord will furnish Tenant with a reasonable number of initial keys for entrance doors into the Leased Premises and may charge Tenant for additional keys, thereafter. All such
keys shall remain the property of Landlord. No additional locks are allowed on any door of the Leased Premises without Landlord’s prior written consent, and Tenant shall advise Landlord of any duplicate keys that Tenant in its sole discretion
deems necessary to operate its business. Tenant shall provide a periodically updated list of the holders of any keys to Landlord. Upon termination of this Lease, Tenant shall surrender to Landlord all keys to the Leased Premises, and give to
Landlord the combination of all locks for safes and vault doors, if any, in the Leased Premises. 

  

 F-3 

 Landlord reserves the right to rescind any of these rules and regulations and to make future rules and regulations
reasonably required for the safety, protection and maintenance of the Building, the Project, the operation and preservation of the good order thereof, and the protection and comfort of the tenants and their employees and visitors. Such rules and
regulations, when made and written notice thereof given to Tenant, shall be binding as if originally included herein. 
  

 F-4 

 EXHIBIT G 
  
 Tenant Improvements Loan Amortization Memorandum 
  

																			
		
	 LANDLORD:
	  	WOODSIDE TECHNOLOGY CENTER, LLC
		
	 TENANT:
	  	FOXHOLLOW TECHNOLOGIES, INC.
		
	 LEASE DATE:
	  	May 3, 2004
		
	 PREMISES:
	  	Located at 740 Bay Road, Redwood City, California

  
 Tenant hereby confirms
and acknowledges that Landlord has disbursed a Tenant Improvements Loan to Tenant in the amount of
                                 Dollars
($                    ). The Tenant Improvements Loan shall be repayable by Tenant to Landlord in monthly installments in the amount of
                                 Dollars
($                    ). 
  

																			
	 	 	 	 	 LANDLORD:
	  	 WOODSIDE TECHNOLOGY CENTER, LLC,
 a Delaware limited liability company

					
	 	 	 	 	 	  	By:	 	 National Office Partners Limited Partnership,
 a Delaware limited partnership,
 its sole member

						
	 	 	 	 	 	  	 	 	By:	 	 Hines National Office Partners Limited Partnership,
 a Texas limited partnership,
 its general partner

							
	 	 	 	 	 	  	 	 	 	 	By:	 	 Hines Fund Management, L.L.C.,
 a Delaware
limited liability company,
 its general partner

								
	 	 	 	 	 	  	 	 	 	 	 	 	By:	 	 Hines Interests Limited Partnership,
 a Delaware limited partnership
 its sole member

									
	 	 	 	 	 	  	 	 	 	 	 	 	 	 	By:	 	 Hines Holdings, Inc.,
 a Texas
corporation,
 its general partner

										
	 	 	 	 	 	  	 	 	 	 	 	 	 	 	 	 	By:	 	  

										
	 	 	 	 	 	  	 	 	 	 	 	 	 	 	 	 	Its:	 	  

  

 G-1 

																	
			
	 	 	 TENANT:
	  	 FOXHOLLOW TECHNOLOGIES, INC.,
 a Delaware corporation

				
	 	 	 	  	By:	 	  

	 	 	 	  	Name:	 	  

	 	 	 	  	Title:	 	  

  

 G-2 

 EXHIBIT H 
  
 Rohm & Haas Indemnity 
  
 [see attached three (3) pages] 
  

 H-1 

 Except from Purchase and Sale Agreement by Rohm and 
 Haas Company (“Seller”) dated February 10, 1997: 
  
 IX. ENVIRONMENTAL INDEMNIFICATION 
  
 9.1. Definitions. For purposes of this Article IX, the terms listed below are defined as follows: 
  
 (a) “Costs” means any and all liabilities, penalties, fines personal injury or property damages (including diminution in the value of the
Property), losses, costs, expenses and reasonable attorneys’, experts’ and consultants’ fees and disbursements incurred by Buyer or the Indemnitees due to the presence of Hazardous Materials at, on, in, under or from the Property
(including in soil, surface or groundwater) on or before the Closing Date. 
  
 Costs shall include, without limitation: (i) costs and expenses of remediation, removal, abatement, cleanup, closure, response, investigation and monitoring of any condition relating to Hazardous Materials, together
with all related costs, expenses, losses, damages, penalties, fines, obligations, judgments and disbursements; (ii) costs required to take necessary precautions to protect against the release or spreading a Hazardous Materials at, on, in, or under
the Property or the migration of Hazardous Materials from the Property; (iii) costs incurred to comply, in connection with all or any portion of the Property, with all applicable laws, regulations, orders and demands with respect to Hazardous
Materials; (iv) costs incurred to comply with any injunctive action or order of any governmental agency or authority; and (v) costs incurred to remove any liens imposed by law in favor of the federal or any state or local government or governmental
agency or authority or private individual, partnership, corporation or other business entity in each case due to the presence of Hazardous Materials at, on, in, under or emanating from the Property (including in soil, surface or groundwater) on or
before the Closing Date. 
  
 (b) “Hazardous Materials”
means: 
  
 (i) Those substances included within the definitions
of “hazardous substances,” “hazardous materials,” “toxic substances,” or “solid waste” in the Comprehensive Environmental Response, Compensation and Liability Act of 1980 (42 U.S.C. § 9601, et seq.)
(“CERCLA”), as amended by Superfund Amendments and Reauthorization Act of 1986 (Pub. L. 99-499 100 Stat. 1613) (“SARA”), the Resource Conservation and Recovery Act of 1976 (42 U.S.C. § 6901 et seq.) (“RCRA”), and
the Hazardous Materials Transportation Act (49 U.S.C. § 1801 et seq.), and in the regulations promulgated pursuant to said laws, all as amended; 
  

 H-2 

 (ii) Those substances listed in the United States Department of Transportation Table (49 CFR 172.101 and
amendments thereto) or by the Environmental Protection Agency (or any successor agency) as hazardous substances (40 CFR 302 and amendments thereto); 
  
 (iii) Petroleum, asbestos, polychlorinated biphenyls, nammabic explosives, radioactive materials or any other material, waste or substances designated as
a “hazardous substance” pursuant to Section 311 of the Clean Water Act (33 U.S.C. § 1251 et seq.) or listed pursuant to Section 307 of the Clean Water Act; 
  
 (iv) Those substances defined as “Hazardous Wastes,” “Hazardous Substances,” or “Hazardous
Materials” in the California Water Code, California Civil Code, California Health & Safety Code and in any regulations promulgated thereunder; and 
  
 (v) Such other substances, materials and wastes which are, or are regulated as, hazardous or toxic to human health or the environment under applicable
local, state or federal law, or the United States government, or which are classified as hazardous or toxic under federal, state, or local laws or regulations. 
  

(c) “Indemnities” means Buyer and Buyer’s employees, managers, directors, shareholders, members, agents, lenders, contractors,
consultants, licensees, tenants, successors and assigns, and their successors and assigns. 
  
 9.2 Indemnification 
  
 (a) Subject to Seller’s rights to perform the Remediation Work pursuant to Section 8.3, Seller shall, at its sole cost and expense, indemnify, defend with legal counsel acceptable to Buyer, protect and hold harmless Buyer and
Buyer’s Indemnitees from and against any and all Costs. 
  
 (b) Seller’s indemnity is freely assignable by Buyer on a non-exclusive basis without the consent of Seller. The indemnities provided under this Article IX shall inure to the benefit of Buyer, Buyer’s Indemnitees and their
respective successors and assigns. 
  
 (c) Seller’s
obligation to indemnify Buyer shall be subject to Seller’s right to perform the Remediation Work pursuant to Section 8.3 and shall not apply to Hazardous Materials brought onto the Property by Buyer or Buyer’s Indemnities. In addition,
Seller’s obligation pursuant to this Article IX shall not apply to Hazardous Materials brought onto the Property after the Closing Date by Buyer or Buyer’s Indemnities or by third parties or to any Costs directly or indirectly arising out
of the introduction or migration of Hazardous Materials onto the Property after the Closing Date. 
  
 (d) Subject to the provisions of this Section 9.2, nothing contained in this Article IX shall be deemed to constitute a waiver of any right or remedy,
including the right to contribution, which Seller or Buyer may have against the other or any other party under any applicable federal, state or local statutory or common law (in each case as amended from time to time), all such rights being hereby
expressly reserved. 
  

 H-3 

 9.3. Procedures Relating to Indemnification. 
  
 (a) Buyer shall promptly, but in any event within ten (10) days of receipt
of any communication from any governmental authority or third party regarding Hazardous Materials at, on, in, under or from the Property (including in any soil, surface or groundwater at or beneath the Property) give notice of same to Seller, and
provide Seller the opportunity to participate or intervene in any discussions or proceedings. Seller shall have the right to control the defense or settlement of any such alleged liabilities or claims, but any Indemnitee may, at its election,
participate in the defense of any action or proceeding at its expense. Should Seller fail to defend any alleged liabilities or claims, then in addition to any other remedies, the Indemnitees may settle (provided that before accepting a settlement it
shall give Seller not less than fifteen (15) days prior notice of the terms thereof and the right to reject the same and, instead, to immediately pay all of Indemnitees’ costs and expenses of defense and thereafter undertake such defense) or
defend such action or proceeding through legal counsel of their own choosing and may recover from Seller and all of their costs and expenses of defense, including their reasonable legal fees. 
  
 (b) If any Hazardous Material found on the Property after the Closing Date is
a Hazardous Material listed in the Environmental Documents and such Hazardous Material (A)(i) is found in a different concentration than the concentration for such Hazardous Material indicated in such Environmental Documents or (ii) is found in a
different location than the location of such Hazardous Material indicated in such Environmental Documents, and (B) is not a Hazardous Material which was brought onto or used on the Property by Buyer, it shall be presumed that such Hazardous Material
is a Hazardous Material which was present on the Property on the Closing Date, and Seller shall indemnify Buyer with respect to such Hazardous Material until Seller and Buyer agree as to whether such Hazardous Material was present on the Property on
the Closing Date or, failing such agreement, such issue is resolved by a court of competent jurisdiction. 
  
 (c) If any government agency requires the investigation, site monitoring, containment, cleanup, removal, restoration or other Remediation Work relating to
the Property for which Seller is liable or presumed to be liable hereunder, Seller shall immediately take action to comply with such requirements and shall thereafter diligently prosecute all such Remediation Work to completion. 
  
 (d) If Seller shall fail promptly to commence, or cause to be commenced, or
fail diligently to prosecute to completion, such Remediation Work which is the obligation of Seller hereunder, then Buyer may, but shall not be required to, cause such Remediation Work to be performed and all Costs shall be paid by Seller within ten
(10) days of Seller’s receipt of written demand from Buyer. 
  
 9.4. Survival. This Article IX shall survive the Closing. 
  

 H-4Prepared by R.R. Donnelley Financial -- Master License Agreement between the Registrant and Surmodics, Inc.

 Exhibit 10.11 
  

	
	Confidential treatment has been requested for portions of this exhibit. The copy filed herewith omits the information
subject to the confidentiality request. Omissions are designated as *****. A complete version of this exhibit has been filed separately with the Securities and Exchange Commission.

  
 MASTER LICENSE
AGREEMENT 
  
 THIS AGREEMENT by and between SurModics, Inc., a corporation of
the State of Minnesota, which has an office at 9924 West 74th Street, Eden Prairie, MN 55344, (hereinafter referred to as SURMODICS), and FoxHollow Technologies, Inc., a corporation of the State of Delaware, which has an office at 3355 Edison
Way, Menlo Park, CA 94025 (hereinafter referred to as FOXHOLLOW). 
  
 WHEREAS, SURMODICS is engaged in biological, chemical and technical research and has developed a body of technology and know-how, including reagents, processes and devices which the parties believe will improve the performance of various
products and processes of FOXHOLLOW. 
  
 WHEREAS, the technology of SURMODICS
includes confidential information (including trade secrets and other know-how) which is proprietary to SURMODICS and SURMODICS is in the process of securing patent coverage for certain items of its technology, and continues to maintain the
confidentiality of other portions of its technology. 
  
 WHEREAS, FOXHOLLOW and
SURMODICS are parties to a Mutual Confidential Disclosure Agreement dated February 3, 1999 (“Prior Disclosure Agreement”); 
  
 WHEREAS, FOXHOLLOW may desire to acquire additional licenses under SURMODICS’ know-how and patent rights such licenses to be added to this Master Agreement;

  
 NOW, THEREFORE, in consideration of the mutual covenants and agreements set
forth below and for other good and valuable consideration of which receipt is acknowledged, the parties agree as follows: 
  

	1.	DEFINITIONS 

  
 The following definitions apply to this Agreement and to all addenda thereto: 
  
 a. “Affiliate” means any entity which owns at least 50% of, is at least 50% owned by, or is under common (at least
50%) ownership with FOXHOLLOW. 
  
 b. “Effective Date”
means the date upon which this Agreement is fully executed. 
  
 c. “Know-how” means SURMODICS’ Confidential Information relating to the surface-treatment of medical devices and which SURMODICS has the right to transmit to others. Know-how includes but is not limited to information
contained in pending patent applications of Patent Rights and information that is Confidential Information as defined in Paragraph 13. 
  
 d. “Licensed Products” means each of the separately sold Medical Products specifically described in Attachment B1, B2, and so forth, and which:

  

 1 

 i. but for the license granted herein the manufacture, use or sale would infringe (or a surface treatment
process employed to produce a product or a reagent used in such process would infringe) any claim of Patent Rights, or 
  
 ii. are produced through the use of SURMODICS’ Know-how. 
  
 e. “Licensed Product Effective Date” for each license granted herein shall mean the date specified in the respective Attachment B1, B2, and so
forth. 
  
 f. “Medical Products” means products that
are specifically described in Attachment B1, B2, and so forth. 
  
 g. “Net Sales” means the total actual billing for sales of Licensed Products, less the following deductions where they are applicable with respect to such billings and when separately shown on invoices: 
  
 i. discounts actually allowed and taken; 
  
 ii. any customs, duties, taxes or other governmental excise or charge upon
or measured by the production, sale, transportation, delivery or use of Licensed Product and actually paid by FOXHOLLOW; 
  
 iii. amounts allowed or credited on rejections or returns; 
  
 iv. transportation charges prepaid or allowed. 
  
 Notwithstanding the above, if any Licensed Product is sold both separately and as an integral part of a combination product containing one or more
integral components in addition to that Licensed Product, then Net Sales of that Licensed Product resulting from sales of that combination product will be calculated by multiplying the Net Sales for the combination product as calculated above by the
fraction A/B where A is the invoice price of the Licensed Product as sold separately and B is the invoice price of the combination product 
  
 A Licensed Product shall be considered sold when it is shipped or when it is invoiced, whichever is earlier. To assure SURMODICS the full royalty payment
contemplated in this Agreement, FOXHOLLOW agrees that in the event any Licensed Product is sold to an Affiliate for purposes of resale, Earned Royalties for that Licensed Product shall be computed upon the weighted average selling price at which
such Licensed Product would ordinarily be sold to a non-Affiliate, rather than on the selling price of FOXHOLLOW to the Affiliate. 
  
 h. “Patent Rights” means the patent application(s) and patent(s) identified in Attachment A hereof, together with all foreign counterparts,
divisions, and continuation applications based thereon, any patent issuing on any of said applications, and any reissues or extensions based on any of such patents. 
  

 2 

 i. “Valid Claim” means a claim of an issued patent of Patent Rights that has not been held
invalid by a court of competent jurisdiction beyond possibility of appeal. 
  

	2.	LICENSE 

  
 a. With respect to the Licensed Product defined in each of Attachments B1, B2, and so forth, SURMODICS grants to FOXHOLLOW, a separate worldwide license
under SURMODICS’ Patent Rights and Know-how to make, have made for it, use, import, have imported, offer for sale and sell that Licensed Product. The license granted herein is expressly limited to the specific Licensed Products defined herein,
and does not include the right to sublicense. Additional terms of each license are set out in the respective Attachments B1, B2, and so forth. To the extent of any inconsistency between the terms set forth in the text of this Agreement and the terms
set forth in Attachments B1, B2, and so forth, the terms set forth in the text of this Agreement shall be controlling. Each such license shall be effective as of its Licensed Product Effective Date. 
  
 b. Subject to the limited license granted herein, SURMODICS shall retain all
rights to the Patent Rights and Know-how. SURMODICS shall retain the right to use Patent Rights and Know-how for its own research purposes. 
  
 c. FOXHOLLOW shall notify SURMODICS, in advance and in writing, of any change in the location of the production of a Licensed Product or any new location
to be used for the production of a Licensed Product. 
  

	3.	LICENSE FEES 

  
 For each license granted by SURMODICS, FOXHOLLOW shall pay to SURMODICS a License Fee as set out in the respective Attachment B1, B2, and so forth.

  

	4.	ROYALTIES 

  
 For each license granted herein, FOXHOLLOW shall pay to SURMODICS a royalty for each quarter calendar year during the term of this License Agreement which
will be the greater of the royalties of Paragraphs 4(a) or 4(b). 
  
 a. Earned Royalties shall be calculated as provided for in the respective Attachment B1, B2, and so forth. No more than one Earned Royalty shall be paid by FOXHOLLOW for any Licensed Product. However, if any Licensed Product is covered by
more than one Attachment B1, B2, and so forth, then the Earned Royalty rate shall be the highest rate specified for such Licensed Product. 
  
 b. Minimum Royalties shall be paid for each Licensed Product as provided for in the respective Attachment B1, B2, and so forth. 
  

 3 

	5.	ROYALTY PAYMENTS, REPORTS, RECORDS 

  
 a. During the term of this Agreement, and for each license granted hereunder, FOXHOLLOW will make written reports and payments to SURMODICS within thirty
(30) days after the last day of each calendar quarter ending March 31, June 30, September 30, and December 31. Each such report shall state the Net Sales, unit volumes, Earned Royalty, corrections of error in prior royalty payments, and data and
calculations used by FOXHOLLOW to determine such payments for each of the licenses corresponding to the respective Attachments B1, B2, and so forth. Each report shall be accompanied by payment in full of the royalty due SURMODICS for that quarter.
The December 31 quarterly report shall also include a nonbinding forecast of reagent usage for the next calendar year. 
  
 b. FOXHOLLOW will maintain, for a period of five (5) years following each sale of Licensed Product, true and accurate records supporting the reports and
payments made under this Agreement. Upon reasonable advance notice SURMODICS shall have the right to carry out an audit of such records no more frequently than once per calendar year by a certified public accountant of its choice. Such accountant
shall have reasonable access to FOXHOLLOW’s offices and the relevant records, files and books of account, and such accountant shall have the right to examine any other records reasonably necessary to determine the accuracy of the calculations
provided by FOXHOLLOW under Paragraph 5(a). Such audit shall be at SURMODICS’ expense except that if an underpayment error is found for any twelve month period that exceeds 10% of the payment made to SURMODICS for that period, then FOXHOLLOW
will bear the cost of such audit. 
  
 c. All royalties on sales
of each Licensed Product to be paid to SURMODICS by FOXHOLLOW under this Agreement shall be paid in U.S. Dollars to SURMODICS in the United States. For the purpose of calculating Earned Royalties on sales outside the United States for any calendar
quarter, FOXHOLLOW shall utilize the average rate of exchange on the last business day of that calendar quarter as quoted in the Wall Street Journal. 
  
 d. Any sum required under U.S. tax laws (or the tax laws of any other government) to be withheld by FOXHOLLOW from payments due hereunder for the account
of SURMODICS shall be promptly paid by FOXHOLLOW for and on behalf of SURMODICS to the appropriate tax authorities, and FOXHOLLOW shall furnish SURMODICS with official tax receipts or other appropriate evidence issued by the appropriate tax
authorities sufficient to enable SURMODICS to support a claim for income tax credit in respect to any sum so withheld. 
  

	6.	DEVELOPMENT FEES 

  
 FOXHOLLOW agrees to pay SURMODICS for development efforts (“Development Fees”) while working on FOXHOLLOW’s products at SURMODICS’
then standard hourly rate for development efforts provided, however, that such development effort is pursuant to a mutually agreed upon project plan. SURMODICS’ standard hourly rate includes direct labor costs plus direct labor overhead.
SURMODICS shall additionally 
  

 4 

 charge direct materials plus direct materials overhead of fifteen percent (15%). Direct materials may
include expenses such as travel and special equipment, but only as mutually agreed upon in writing. SURMODICS shall invoice FOXHOLLOW monthly for such Development Fees and payment shall be made within thirty (30) days thereafter. 
  

	7.	TERM 

  
 a. Unless earlier terminated, each license herein granted shall begin upon the Licensed Product Effective Date set out in the respective Attachment B1,
B2, and so forth, and shall extend for each Licensed Product so licensed on a country-by-country and product-by- product basis until expiration of the last to expire patent of Patent Rights that covers that Licensed Product in such country or for a
period of fifteen (15) years following the first bona fide commercial sale of such Licensed Product in such country, whichever is longer. 
  
 b. Upon expiration of the full term of the license granted herein for any Licensed Product, and upon full payment by FOXHOLLOW to SURMODICS of any monies
due under this Agreement, the license with respect to Know-how licensed herein for that Licensed Product shall be deemed paid up and non-exclusive (if any such license was exclusive), and SURMODICS may negotiate additional license agreements with
any other party for that Licensed Product. 
  

	8.	PATENTS 

  
 a. At such time as SURMODICS provides to FOXHOLLOW the appropriate patent numbers, FOXHOLLOW shall see to it that all Licensed Products sold by FOXHOLLOW
shall be appropriately marked with the applicable patent numbers, in conformity with applicable law. 
  
 b. SURMODICS recognizes that it is an objective of FOXHOLLOW to obtain patents on technology that it develops concerning chemicals having latent reactive
groups and their uses. FOXHOLLOW recognizes that a vital part of SURMODICS’ business involves the licensing of others under SURMODICS’ patents and know-how to make, use and sell products, and that it is an objective of SURMODICS to enable
its present and future licensees to exploit patent licenses from SURMODICS to produce and sell products without interference from any patent that FOXHOLLOW might obtain. A purpose of this Paragraph 8(b) is to establish a system under which each
party may accomplish its respective objective. 
  
 i.
“FOXHOLLOW Latent Reactive Chemical Patents” (FOXHOLLOW LRC Patents) means patents which (a) claim inventions conceived or first reduced to practice during the term of this Agreement solely by one or more FOXHOLLOW employees or others who
are required to assign inventions to FOXHOLLOW, and (b) claim inventions relating to chemical species (LRC Compositions) having photo-reactive or other latent reactive groups for the purpose of bonding chemicals such as synthetic polymers and
biologically active materials onto surfaces or into matrices or to other molecules, the use of such chemicals species, or the products resulting from such use. 
  

 5 

 ii. During the term of this Agreement, FOXHOLLOW will provide SURMODICS with a copy of each proposed
patent application for a FOXHOLLOW LRC Patent, and SURMODICS will provide comments concerning such application, including comments regarding inclusion of SURMODICS’ Confidential Information, prior work done by SURMODICS in connection with the
claimed invention, and the state of the art. 
  
 In the event
such proposed patent application contains SURMODICS Confidential Information, SURMODICS will provide written notice to FOXHOLLOW, within thirty (30) days of receipt of the proposed application, specifically identifying such SURMODICS Confidential
Information. If FOXHOLLOW does not receive such written notice, FOXHOLLOW may proceed with the filing of such proposed patent application. If FOXHOLLOW does receive such written notice, FOXHOLLOW may strike such SURMODICS Confidential Information
and proceed with filing the proposed patent application. If FOXHOLLOW does not agree that the language in question is SURMODICS Confidential Information, FOXHOLLOW may seek resolution under Paragraph 24; provided however, no proposed patent
application shall be filed until such dispute is resolved. 
  
 If
SURMODICS can fairly show that it had substantial knowledge of the invention of any FOXHOLLOW LRC Patent application before receiving from FOXHOLLOW that patent application, SURMODICS shall promptly notify FOXHOLLOW and the parties shall cooperate
in comparing records of conception of that invention to determine in good faith which party was the earliest to conceive the invention. To the extent that any dispute arises with respect to (a) the classification of an invention as a sole invention
of FOXHOLLOW or (b) SURMODICS having substantial knowledge of the invention or (c) which party was the earliest to conceive the invention, the disputing party shall promptly inform the other party of the nature of the dispute and the provisions of
Paragraph 24 shall apply. 
  
 iii. SURMODICS shall have and is
hereby granted a noncancelable, nonexclusive worldwide license, with the right to sublicense, to make, have made for it, use and sell products and processes covered by each FOXHOLLOW LRC Patent to the extent that such manufacture, use or sale also
is covered by any claim of any patent that SURMODICS has the right to license to others or may have licensed to others. The license granted to SURMODICS is limited to claims of FOXHOLLOW LRC Patents that would otherwise be infringed by the making of
an LRC Composition or the use of an LRC Composition to provide a coating upon a substrate or the combination of a coating derived from an LRC Composition and the substrate upon which it is coated. Any such sublicense shall be limited to the practice
of FOXHOLLOW LRC Patents only in combination with the practice of SURMODICS Patent Rights or Know-how. If FOXHOLLOW was the earliest to conceive the invention of that patent, then the license granted to SURMODICS, and SURMODICS’ right to
sublicense, shall exclude the right to manufacture, use or sell Medical Products. 
  

 6 

 iv. In return for such license, SURMODICS will pay FOXHOLLOW a total of [***] of the royalties
(regardless of the number of FOXHOLLOW LRC Patents that are licensed to SURMODICS or the number of licenses involved) that SURMODICS receives from its sublicensees based on sales by its sublicensees of products that but for such sublicenses would
infringe any Valid Claim of FOXHOLLOW LRC Patents. In addition, SURMODICS will pay FOXHOLLOW a total of [***] of the Net Sales of products manufactured or sold by SURMODICS which but for the license granted under Paragraph 8(b)(ii), the manufacture
or sale would infringe a claim of an issued FOXHOLLOW LRC Patent (regardless of the number of FOXHOLLOW LRC Patents involved) that has not been held invalid by a court of competent jurisdiction beyond possibility of appeal. Notwithstanding the
above, if SURMODICS was the earliest to conceive the invention of any FOXHOLLOW LRC Patent, then the license granted to SURMODICS shall be considered paid-up. 
  

c. The parties agree to execute and exchange upon request such documents as may be necessary or desirable to carry out the provisions of Paragraph
8(b). 
  

	9.	ALLOCATION OF ROYALTIES 

  
 The Earned Royalty rate with respect to any Licensed Product shall be prospectively reduced to fifty percent (50%) of the Earned Royalty rate set out hi Paragraph 4(a)
and the respective Attachments B1, B2, and so forth, to the extent that and during the term that neither the manufacture, nor the use, nor the sale of mat specific Licensed Product (or a surface treatment process or a reagent used in such, process)
is covered by any Valid Claim of Patent Rights. The provisions of this Paragraph 9 shall not apply to payment of Minimum Royalties as provided in Paragraph 4(b) and the respective Attachments B1, B2, and so forth. 
  

	10.	TERMINATION 

  
 a. For each license granted herein: 
  
 i. FOXHOLLOW shall have the right to terminate the respective Attachment B1, B2, and so forth, under which such license was granted, but only in its
entirety, at any time upon ninety (90) days advance written notice. Upon termination of such license, FOXHOLLOW shall have no further rights under Patent Rights or Know-how. However, FOXHOLLOW shall be allowed to sell any inventory of Licensed
Products existing at the time of termination for a period of six (6) months thereafter (thereafter destroying any remaining inventory), provided FOXHOLLOW accounts for such sales of inventory and pays SURMODICS the appropriate Earned Royalty for
such sales as set out in Paragraph 4(a) of this Agreement. 
  

	***	Certain information on this page has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the
omitted portions. 

  

 7 

 ii. SURMODICS may terminate this Agreement in whole or with respect to any license granted herein upon
thirty (30) days written notice for any material breach or default by FOXHOLLOW, including without limitation, failure to comply with the confidentiality provisions of Paragraph 13, failure to make reports and payments when due, failure to pay
Minimum Royalties, and withholding or notice of intent to withhold any royalties provided for in this Agreement. Said termination under this Paragraph 10(a)(ii) shall become effective at the end of the thirty (30) day period unless during that
period FOXHOLLOW shall first cure such breach or default. 
  
 iii. Upon termination of any license under any of the provisions of this Paragraph 10, but subject to the provisions of Paragraph 10(a)(i), referring to the sale of inventory, FOXHOLLOW shall cease making, having made for it, using and
selling the Licensed Products of such license that are produced through the use of SURMODICS’ Know-how. SURMODICS shall have the right to seek equitable relief to enforce the provisions of this Paragraph 10(a)(iii). 
  
 b. Either party may terminate this Agreement if the other party hereto is
involved in insolvency, dissolution, bankruptcy or receivership proceedings affecting the operation of its business. 
  
 c. Notwithstanding the provisions of Paragraph 20, failure of FOXHOLLOW to initiate bona fide commercial sales of any Licensed Product by the date set out
for that Licensed Product in the respective Attachment B1, B2, and so forth, to this Agreement shall permit SURMODICS to terminate the license for that Licensed Product upon thirty (30) days written notice at any time prior to the date FOXHOLLOW
begins bona fide commercial sales of that Licensed Product. 
  
 d. In the event that all licenses granted herein are terminated, SURMODICS shall have the right to terminate this Agreement in its entirety upon written notice. 
  

	11.	CONTINUING OBLIGATIONS SUBSEQUENT TO TERMINATION 

  
 a. Upon any termination of this Agreement or any of the licenses granted herein, the following rights and obligations shall continue to the degree
necessary to permit their complete fulfillment or discharge: 
  
 i. SURMODICS’ right to receive and FOXHOLLOW’s obligation to pay royalties to the extent owed; and 
  
 ii. FOXHOLLOW’s obligation to maintain records and SURMODICS’ right to audit under Paragraph 5, with respect to sales made and to be made under
Paragraph 10(a)(i); and 
  
 iii. Any cause of action or claim of
either party, accrued or to accrue, because of any breach or default by the other party; and 
  
 iv. Each party’s obligation to maintain confidentiality under Paragraph 13; and 
  

 8 

 v. FOXHOLLOW’s obligation to forebear from use of SURMODICS’ Know-how as provided in Paragraph
10(a)(iii); and 
  
 vi. The parties’ obligations under
Paragraph 8(b) with respect to filing patent applications and payment of royalties on issued patents. 
  
 b. Within thirty (30) days of the date of termination of this Agreement, each party shall return to the other party all copies of documents and other
materials containing or disclosing any of the other parties Confidential Information; provided, however, SURMODICS shall be allowed to keep all documents related to the reporting and payment of royalties under this Agreement. 
  

	12.	REPRESENTATIONS AND WARRANTIES 

  
 a. Each party warrants to the other that it has not accepted and will not accept commitments or restrictions with respect to its rights or obligations
under this Agreement which will materially affect the value of the rights granted by SURMODICS nor the obligations undertaken by FOXHOLLOW. 
  
 b. Each party has the full and unrestricted right to enter into this Agreement. 
  
 c. Nothing in this Agreement shall be construed as: 
  
 i. A warranty or representation by SURMODICS as to the validity or scope of any Patent Rights; or 
  
 ii. A warranty or representation that anything made, used, sold, or
otherwise disposed of, or any process practiced, under any License granted in this Agreement is or will be free from infringement of patents of third persons; provided, however, as of the Effective Date of this Agreement, SURMODICS is not presently
aware of any challenge to the validity of any Patent Rights in any court or any allegation of misappropriation or misuse of the Know-how; or 
  
 iii. A requirement that SURMODICS file any patent application, secure any patent, or maintain any patent in force; or 
  
 iv. An obligation to bring or prosecute actions or suits against third
parties for infringement of any patent; or 
  
 v. An obligation
to furnish any manufacturing or technical information not encompassed within Know-how; or 
  
 vi. Conferring any right on either party to use in advertising, publicity, or otherwise any trademark or trade name of the other; or 
  

 9 

 vii. Granting by implication, estoppel, or otherwise any licenses or rights under patents or other
proprietary information of SURMODICS other than those included within Patent Rights and Know-how. 
  
 d. WITH RESPECT TO PHOTO-REACTIVE REAGENTS SUPPLIED AT ANY TIME BY SURMODICS, SURMODICS DISCLAIMS ALL WARRANTIES, EXPRESS OR IMPLIED, INCLUDING BUT NOT
LIMITED TO WARRANTIES OF MERCHANTABILITY, NON-INFRINGEMENT AND FITNESS FOR A PARTICULAR PURPOSE. NOTWITHSTANDING ANYTHING TO THE CONTRARY, IN CONNECTION WITH THE SALE OR USE OF PHOTO-REACTIVE REAGENTS, SURMODICS SHALL NOT BE LIABLE FOR INCIDENTAL,
CONSEQUENTIAL, SPECIAL, EXTRAORDINARY OR PUNITIVE DAMAGES OF ANY DESCRIPTION, WHETHER FOR DAMAGE TO REPUTATION OR GOODWILL, LOST PROFITS, CLAIMS OF THIRD PARTIES OR OTHERWISE, WHETHER SUCH ASSERTED DAMAGE PURPORTS TO BE BASED ON WARRANTY OR
GUARANTEE, INDEMNITY OR OTHER CONTRACT, CONTRIBUTION, NEGLIGENCE OR OTHER TORT, OR OTHERWISE. 
  
 e. SURMODICS does not make any representations, extend any warranties of any kind, either express or implied, or assume any responsibilities whatever with respect to use, sale, or other disposition by FOXHOLLOW or its
vendees or transferees of Licensed Products incorporating or made by use of the Patent Rights and Know-how licensed under this Agreement. 
  
 f. FOXHOLLOW represents that it will make reasonable commercial efforts to bring to market and to sell Licensed Product throughout FOXHOLLOW’S
world-wide marketing territory during the term of this Agreement. SURMODICS expects FOXHOLLOW to demonstrate appropriate product development activities, participate in clinical trials, submit appropriate regulatory or governmental filings for
appropriate marketing clearances, integrate the Licensed Product into FOXHOLLOW’S manufacturing operations, educate appropriate sales and marketing staff, and introduce and actively market the Licensed Product upon completion of product
development and obtaining appropriate regulatory approvals. 
  

	13.	CONFIDENTIALITY 

  
 a. Each party agrees to retain in confidence all Know-how and other information received from the other, including without limitation, information
required to be maintained in confidence under prototype development or manufacturing scale-up or post scale-up relationships between the parties, for a period of ten (10) years from the date of disclosure or five (5) years from the date of
termination of this Agreement, whichever is longer. Each party agrees not to disclose any of such Know-how or other information to third parties nor to use the same except in accordance with this Agreement. Each party’s obligation of
non-disclosure and non-use shall not apply to information which: 
  
 i. at the time of its disclosure to the receiving party is available to the public; 
  

 10 

 ii. after disclosure becomes available to the public through no fault of the receiving party; 

 
 iii. the receiving party can show was in its possession at the time of
disclosure to it by the other; 
  
 iv. the receiving party can
show was received by it from a third party without breach of a confidential obligation; or 
  
 v. the receiving party is compelled by application of law or legal process to divulge, but the receiving party shall provide the disclosing parry with advance written notice before divulging the information to enable
the disclosing party to seek a protective order or employ other means to preserve the confidential nature of that information. 
  
 Even after any of such information becomes available to the public, each party shall not disclose without the other’s prior written approval the fact
that such information was furnished by or originated with the other. 
  
 b. For the purpose of this entire Paragraph 13, Know-how or other information which is specific shall not be deemed to be within any of the specified exceptions merely because it is embraced by more general information in such exception. In
addition, any combination of features shall not be deemed to be within any of the specified exceptions merely because individual features are in such exception, but only if the combination itself and its principle of operation are in such exception.

  
 c. Notwithstanding the above, FOXHOLLOW specifically agrees
that it will not disclose to any Affiliates or other third party any of SURMODICS’ Know-how relating to the manufacture of SURMODICS’ chemical reagents, the precise chemical composition of such reagents, how such reagents are tested, how
they are quality controlled, and any other specific information concerning the production of such reagents. 
  
 d. The provisions of this entire Paragraph 13 shall survive termination of this Agreement for any reason. 
  
 e. Nothing herein shall in any way affect the obligations of the parties
under any prior secrecy or confidential disclosure agreements, including the Prior Disclosure Agreement, which obligations shall continue in accordance with the terms of each such agreement to the extent not inconsistent with the present Agreement.

  

	14.	ASSIGNMENT 

  
 This Agreement shall be binding upon and inure to the benefit of the parties hereto and their successors and permitted assigns. Either party may assign
its rights and obligations under this Agreement to a financially responsible third party, but only in connection with a complete transfer to the third party of the business to which this Agreement pertains. The assigning party will so inform the
other party to this Agreement without delay of any assignment made in accordance with the conditions of this Agreement. This Agreement 
  

 11 

 shall not otherwise be assignable by either party without the prior written consent of the other party.
Any and all assignments of this Agreement or any interest therein not made in accordance with this paragraph shall be void. 
  

	15.	GOVERNMENT APPROVAL 

  
 FOXHOLLOW shall have the sole responsibility, at FOXHOLLOW’s sole expense, for obtaining any government approvals that may be required for the
investigation or marketing of Licensed Products. 
  

	16.	PRODUCT LIABILITY 

  
 FOXHOLLOW will defend and indemnify SURMODICS against all third party losses, liabilities, lawsuits, claims, expenses (including attorney’s fees),
costs, and judgments incurred through personal injury, property damage, or other claims of third parties, arising from the design, manufacture, use, or sale of Licensed Products by FOXHOLLOW, except which are (a) proximately caused solely by
SURMODICS negligent conduct or willful misconduct, or (b) based on a claim of a third party alleging infringement of intellectual property owned or controlled by such third party due solely to the practice of the Patent Rights or Know-how by
FOXHOLLOW. 
  

	17.	NO WAIVER 

  
 Any waiver of any term or condition of this Agreement by either party shall not operate as a waiver of any other or continued breach of such term or
condition, or any other term or condition, nor shall any failure to enforce a provision hereof operate as a waiver of such provision or of any other provision hereof. 
  

	18.	NOTICES 

  
 All communications or other notices required or permitted under this Agreement shall be in writing and shall be deemed to be given when personally
delivered, or when mailed by registered or certified mail, postage prepaid, and addressed as follows: 
  
 If to SURMODICS: 
 License Administration 
 SurModics, Inc. 
 9924 West 74th Street 
 Eden Prairie, MN 55344 
  
 If to FOXHOLLOW: 

President 
 FoxHollow Technologies, Inc. 
 3355 Edison Way 
 Menlo Park, CA 94025 
  

 12 

 Either party shall have the right to change the person and/or address to which notices hereunder shall be
given, by notice to the other party in the manner set out above. 
  

	19.	CAPTIONS 

  
 The captions and headings of this Agreement are for convenience only and shall in no way limit or otherwise affect any of the terms or provisions
contained herein. This Agreement shall be construed without regard to any presumption or other rule requiring construction hereof against the party drafting this Agreement. 
  

	20.	FORCE MAJEURE 

  
 Neither party shall be liable for failure to perform as required by any provisions of this Agreement where such failure results from a cause beyond such
party’s reasonable control such as acts of God, regulation or other acts of civil or military authority, required approval(s) of government bodies, fires, strikes, floods, epidemics, quarantine restrictions, riot, delays in transportation and
inabilities to obtain necessary labor, materials, or manufacturing facilities. In the event of any delay attributable to any of the foregoing causes, the time for performance affected thereby shall be extended for a period equal to the time lost by
reason of such delay. The cumulative effect of all such delays under this Paragraph 20 shall not exceed one (1) year. 
  

	21.	NO AGENCY 

  
 Nothing in this Agreement authorizes either SURMODICS or FOXHOLLOW to act as agent for the other as to any matter, or to make any representations to any
third party indicating or implying the existence of any such agency relationship. SURMODICS and FOXHOLLOW shall each refrain from any such representations. The relationship between SURMODICS and FOXHOLLOW is that of independent contractors.

  

	22.	SEVERABILITY 

  
 Should any provision of this Agreement, or the application thereof, to any extent be held invalid or unenforceable, the remainder of this Agreement and
the application thereof other than such invalid or unenforceable provisions shall not be affected thereby and shall continue valid and enforceable to the fullest extent permitted by law or equity. 
  

	23.	GOVERNING LAW 

  
 For all purposes under this Agreement, the parties agree and admit that jurisdiction and venue are proper in the Federal District Court, District of
Minnesota. This Agreement shall for all purposes be governed and interpreted in accordance with the laws of the State of Minnesota, except for its conflict of laws provisions. 
  

 13 

	24.	ARBITRATION 

  
 a. In the event of any dispute concerning this Agreement, including its interpretation, performance, breach or termination, the procedures of this
Paragraph 24 shall apply; provided, however, that either party shall have the unrestricted right at any time to seek a court injunction prohibiting the other party from making unauthorized disclosure or use of Confidential Information as provided
for in Paragraph 13 or unauthorized use of SURMODICS’ Know-how as provided for in Paragraph 10(a)(iii). 
  
 b. Both parties will use good faith and reasonable efforts to resolve any dispute informally and as soon as practical. If any such dispute is not resolved
informally within a reasonable period, then an officer from each party, having authority to resolve the dispute, will meet at a mutually agreeable time and place to attempt to resolve the dispute. 
  
 c. If the parties are unable to resolve a dispute as provided immediately
above, either party may submit the dispute for resolution by mandatory, binding arbitration in the city of Minneapolis, MN (or such other place as the parties may mutually agree) under the auspices of the American Arbitration Association under
it’s Commercial Arbitration Rules. Each party shall select one independent, qualified arbitrator and the two arbitrators so selected shall then select a third arbitrator in accordance with the Commercial Rules. Each party reserves the right to
object to any individual arbitrator (no matter by whom chosen) who has been employed by or affiliated with a competing organization. 
  
 d. The arbitrators, who shall act by majority vote, shall be empowered to decree any and all relief of an equitable nature, including but not limited to
temporary restraining orders, temporary injunctions, and/or permanent injunctions, and shall also be able to award damages, with or without an accounting of costs. Judgment on the award rendered by the arbitrator(s) may be entered into any court
having jurisdiction thereof. Each party shall bear its own costs and divide other reasonable arbitrator costs equally. 
  

	25.	PHOTO-REACTIVE COMPOUND SUPPLY 

  
 a. SURMODICS agrees to make reasonably available to FOXHOLLOW for purchase in the United States, SURMODICS’ photo-reactive compounds as listed in
Attachments B1, B2, and so forth. To the extent that such compounds are photo-reactive compounds that SURMODICS offers to its other clients, SURMODICS agrees that: (a) the prices to FOXHOLLOW for photo-reactive compounds shall be the same as the
prices that SURMODICS ordinarily offers to its other clients for equivalent volume consumption; (b) for each shipment of photo-reactive compound, SURMODICS will provide written certificate of compliance to mutually agreed upon written
specifications, if any; and (c) SURMODICS will take reasonable steps to adequately stock such photo-reactive compounds that FOXHOLLOW utilizes in the production of Licensed Products. Delivery by SURMODICS of photo-reactive compounds to Federal
Express, or to another reputable carrier in the United States, shall constitute delivery to FOXHOLLOW. 
  

 14 

 b. SURMODICS shall maintain a quality management system which it believes enables it to reliably
manufacture photo-reactive compounds. To the extent that SURMODICS makes photo-reactive compounds available to FOXHOLLOW, SURMODICS will permit its quality system to be audited at SURMODICS’ place of business by FOXHOLLOW. 
  

	26.	ENTIRE AGREEMENT 

  
 This Agreement, together with the Prior Disclosure Agreement and all addenda, attachments, and writings required or contemplated hereby, constitutes the
entire agreement between the parties with respect to the Licenses granted herein, and no party shall be liable or bound to the other in any manner by any warranties, representations or guarantees except as specifically set forth herein. This
Agreement shall not be altered or otherwise amended except by an instrument in writing signed by both parties. 
  
 IN WITNESS WHEREOF, the parties have executed this Agreement on the date last written below. 
  

					
	 SurModics, Inc.
	  	 	 	 FoxHollow Technologies, Inc.

			
	         /s/ Walter H. Diers Jr.

	  	 	 	         /s/ Jeffrey M. Closs

	     Signature
	  	 	 	     Signature

			
	         Walter H. Diers Jr.

	  	 	 	         Jeffrey M. Closs

	     Printed Name
	  	 	 	     Printed Name

			
	         Vice President

	  	 	 	         President & CEO

	     Title
	  	 	 	     Title

			
	         13 August 1999

	  	 	 	         August 24, 1999

	     Date
	  	 	 	     Date

  

 15 

 ATTACHMENTA 
  
 SurModics, Inc. U.S. Patents (may be listed under previous name, BSI Corporation) 
  

	1.	METHOD OF IMPROVING THE BIOCOMPATIBILITY OF SOLID SURFACES 

 U.S. Patent No. 4,973,493 issued 11/27/90 
  

	2.	BIOCOMPATIBLE COATINGS FOR SOLID SURFACES 

 U.S. Patent No.
4,979,959 issued 12/25/90 
  

	3.	PREPARATION OF POLYMERIC SURFACES VIA COVALENTLY ATTACHING POLYMERS 

 U.S. Patent No. 5,002,582 issued 3/26/91 
  

	4.	BIOMOLECULE ATTACHMENT TO HYDROPHOBIC SURFACES 

 U.S.
Patent No. 5,217,492 issued 6/8/93 
  

	5.	METHOD OF BIOMOLECULE ATTACHMENT TO HYDROPHOBIC SURFACES 

 U.S. Patent No. 5,258,041 issued 11/2/93 
  

	6.	BIOCOMPATIBLE DEVICE WITH COVALENTLY BONDED BIOCOMPATIBLE AGENT 

 U.S. Patent No. 5,263,992 issued 11/23/93 
  

	7.	RESTRAINED MULTIFUNCTIONAL REAGENT FOR SURFACE MODIFICATION 

 U.S. Patent No. 5,414,075 issued 5/9/95 
  

	8.	SUBSTRATE SURFACE PREPARATION 

 U.S. Patent No. 5,512,329
issued 4/30/96 
  

	9.	PREPARATION OF CROSSLINKED MATRICES CONTAINING COVALENTLY IMMOBILIZED CHEMICAL SPECIES AND UNBOUND RELEASABLE CHEMICAL SPECIES 

 U.S. Patent No. 5,563,056 issued 10/08/96 
  

	10.	RESTRAINED MULTIFUNCTIONAL REAGENT FOR SURFACE MODIFICATION 

 U.S. Patent No. 5,637,460 issued 6/10/97 
  

	11.	PHOTOACTIVATABLE WATER SOLUBLE CROSSLINKING AGENTS CONTAINING AN ONIUM GROUP 

 U.S. Patent No. 5,714,360 issued 02/03/98 
  

 16 

 SurModics, Inc. U.S. Patent Applications (may be listed under previous name, BSI Corporation) 
  

	1.	VIRUS INACTIVATING COATINGS 

 Filed 6/7/95 
  

	2.	METHOD AND IMPLANTABLE ARTICLE FOR PROMOTING ENDOTHELIALIZATION 

 Filed 5/26/95 
  
 SurModics, Inc. Foreign Patents (may be listed under
previous name, BSI Corporation) 
  

	1.	IMPROVEMENT OF THE BIOCOMPATIBILITY OF SOLID SURFACES 

 Canadian Patent No. 1305068, issued 7/14/92 
 Australian Patent No. 615637, issued 10/16/87 
 EPO Patent No. 0326579, issued 1/11/95 
  

	2.	BIOMOLECULE ATTACHED TO A SOLID SURFACE BY MEANS OF A SPACER AND METHODS OF ATTACHING BIOMOLECULES TO SURFACES 

 Canadian Patent No. 1335721, issued 5/30/95 
  
 SurModics, Inc. Foreign Patent Applications (may be listed under previous name, BSI Corporation) 
  

	1.	BIOCOMPATIBLE COATINGS 

 Filed in Canada, Europe, Japan,
Denmark, and Norway 
  

	2.	PREPARATION OF POLYMERIC SURFACES 

 Filed in Canada,
Europe, Japan, Denmark, and Norway 
  

	3.	IMMOBILIZATION OF CHEMICAL SPECIES IN CROSSLINKED MATRICES 

 Filed in Canada, Europe, Australia, Japan 
  

	4.	IMPROVEMENT OF THE BIOCOMPATIBILITY OF SOLID SURFACES 

 Filed in Japan 
  

	5.	RESTRAINED MULTIFUNCTIONAL REAGENTS FOR SURFACE MODIFICATION 

 Filed in Canada, Europe, Australia and Japan 
  

 17 

 ATTACHMENT B1 
 Atherectomy Catheter 
  

	1.	MEDICAL PRODUCTS 

  
 “Medical Products” means a catheter that is specifically designed and labeled to excise stenotic, sclerotic materials from the coronary vascular
and peripheral vascular (does not include neurovascular) systems. 
  

	2.	LICENSED PRODUCT 

  
 “Licensed Products” means Medical Products which are surface-treated with photo-reactive polyacrylamide, photo-reactive polyvinylpyrrolidone,
tetrabenzoylbenzyl ether or diphotodiquat (latent-reactive crosslinking compounds) or any combination of these photo-reactive reagents. 
  

	3.	GRANT OF LICENSE 

  
 The license granted under this Attachment is non-exclusive. 
  

	4.	LICENSE FEES 

  
 FOXHOLLOW will pay to SURMODICS an initial nonrefundable License Fee payment of $25,000 upon execution of this Attachment and a second nonrefundable
License Fee payment of $25,000 one year from the Licensed Product Effective Date of this Attachment. 
  

	5.	ROYALTY PAYMENTS 

  
 FOXHOLLOW shall pay to SURMODICS a royalty, for the Patent Rights and Know-how license granted herein, which will be the greater of Paragraphs 5(a) or
5(b) as follows: 
  
 a. Earned Royalties of calculated as a
percentage of Net Sales ($U.S.) of Licensed Products sold in each calendar year. The percentage to be used in each calculation during each calendar year shall be based upon the cumulative Net Sales of Licensed Product in the calendar year as
follows: 
  

			
	 Net Sales In Each Calendar Year
	 	Earned Royalty Rate
	 On the first $35,000,000
	 	[***]
	 On the next $35,000,000
	 	[***]
	 On Net Sales over $70,000,000
	 	[***]

  
 b. Quarterly Minimum
Royalties for all Attachment B1 Products during the periods specified as follows: 
  

			
	 Minimum Royalty Periods
	 	Quarterly Minimum Royalty
	 January 1, 2002 to December 31, 2002
	 	$  5,000
	 January 1, 2003 to December 31, 2003
	 	$10,000
	 January 1, 2004 to December 31, 2004
	 	$20,000

  

	***	Certain information on this page has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the
omitted portions. 

  

 18 

 For the quarter calendar year commencing with January 1, 2005, and each year thereafter, the quarter
calendar year Minimum Royalty shall be the prior year’s quarterly Minimum Royalty adjusted by a percentage equal to the percentage change in the “Consumer Price Index For All Urban Consumers” for the prior calendar year as reported by
the U.S. Department of Labor. 
  
 c. There shall be established a
Credit Pool consisting of the License Fees paid to SURMODICS under Paragraph 4 of this Attachment. On a calendar quarter basis, FOXHOLLOW shall have the right to apply moneys in this Credit Pool, if any, against Earned Royalties due to SURMODICS
under this Attachment, and the Credit Pool shall be reduced by the amount so applied. The amount of the Credit Pool that may be applied against Earned Royalties shall be 50% of the Earned Royalty obligation in excess of the Minimum Royalties
obligation for that calendar quarter, not to exceed the remaining balance in the Credit Pool. The Credit Pool shall never be reduced to less than zero. 
  

	6.	PERFORMANCE 

  
 a. Failure of FOXHOLLOW to begin bona fide commercial sales by January 1, 2003, of a Licensed Product as defined in this Attachment, shall permit
SURMODICS to terminate the license for that Licensed Product upon thirty (30) days written notice at any time prior to the date FOXHOLLOW begins bona-fide commercial sales of that Licensed Product. 
  
 b. If, after January 1, 2003, there are four (4) consecutive quarters in
which FOXHOLLOW fails to generate Earned Royalties under Paragraph 5(a) of this Attachment then upon thirty (30) days written notice given to FOXHOLLOW, the license granted herein shall, at SURMODICS’ option, be terminated. 
  
 The Licensed Product Effective Date of this Attachment shall be the date last written below
or the date on which SURMODICS receives all payments due upon execution of this Attachment, whichever is later 
  

					
	 SurModics, Inc.
	  	 	 	 FoxHollow Technologies, Inc.

			
	         /s/ Walter H. Diers Jr.

	  	 	 	         /s/ Jeffrey M. Closs

	     Signature
	  	 	 	     Signature

			
	         Walter H. Diers Jr.

	  	 	 	         Jeffrey M. Closs

	     Printed Name
	  	 	 	     Printed Name

			
	         Vice President

	  	 	 	         President & CEO

	     Title
	  	 	 	     Title

			
	         13 August 1999

	  	 	 	         August 24, 1999

	     Date
	  	 	 	     Date

  

 19 

 AMENDMENT TO ATTACHMENT B1 OF THE MASTER LICENSE AGREEMENT 
  
 This is an Amendment to Attachment B1 of the Master License Agreement (ATTACHMENT B1) between
SurModics, Inc. (SURMODICS) and FoxHollow Technologies, Inc. (FOXHOLLOW), fully executed on August 24, 1999, a copy of which is attached hereto and incorporated herein by reference. 
  
 The parties desire to amend certain terms and conditions contained in ATTACHMENT B1 as follows: 
  
 Modify Paragraph 5(b) to read as follows: 
  

	5.	ROYALTY PAYMENTS 

  
 “b. Quarterly Minimum Royalties for all Attachment B1 Products during the periods specified as follows: 
  

			
	 Minimum Royalty Periods
	 	Quarterly Minimum Royalty
	 January 1, 2003 to December 31, 2003
	 	$  5,000
	 January 1, 2004 to December 31, 2004
	 	$10,000
	 January 1, 2005 to December 31, 2005
	 	$20,000

  
 For the quarter
calendar year commencing with January 1, 2006 and each year thereafter, the quarter calendar year Minimum Royalty shall be the prior year’s quarterly Minimum Royalty adjusted by a percentage equal to the percentage change in the “Consumer
Price Index For All Urban Consumers” for the prior calendar year as reported by the U.S. Department of Labor.” 
  
 Modify Paragraph 6 to read as follows: 
  

	6.	PERFORMANCE 

  
 “a. Failure of FOXHOLLOW to begin bona fide commercial sales by January 1, 2004, of a Licensed Product as defined in this Attachment, shall permit
SURMODICS to terminate the license for that Licensed Product upon thirty (30) days written notice at any time prior to the date FOXHOLLOW begins bona-fide commercial sales of that Licensed Product. 
  
 b. If, after January 1, 2004, there are four (4) consecutive quarters in
which FOXHOLLOW fails to generate Earned Royalties under Paragraph 5(a) of this Attachment then upon thirty (30) days written notice given to FOXHOLLOW, the license granted herein shall, at SURMODICS’ option, be terminated.” 

 IN WITNESS WHEREOF, the parties hereto execute this Amendment by their duly authorized employees. 
  

					
	 AGREED:
	  	 	 	 AGREED:

			
	 SurModics, Inc.
	  	 	 	 FoxHollow Technologies, Inc.

			
	         /s/ James C. President

	  	 	 	     /s/ Robert W. Thomas

	 Signature
	  	 	 	 Signature

			
	         James C. President

	  	 	 	     Robert W. Thomas

	 Printed Name
	  	 	 	 Printed Name

			
	         President

	  	 	 	     President & CEO

	 Title
	  	 	 	 Title

			
	         5/4/02

	  	 	 	     4/29/02

	 Date
	  	 	 	 Date

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