Document:

Guaranty

 

This
Guaranty is made as of this 23rd day of August, 2013 by Fouad Kallamni to [ ] and to [ ] (collectively, “Creditors”)
with respect to obligations of OSO Beverages Corp. (“Debtor”) to Creditors under those certain Senior Secured
Promissory Notes dated August 23, 2013 issued by Debtor to each Creditors and (collectively, the “Notes”).

 

In order to induce
Creditors to make the loans to Debtor evidenced by the Notes, and for other good and valuable consideration, the receipt and sufficiency
of which Guarantor hereby expressly acknowledges, Guarantor covenants and agrees with Creditors as follows:

 

1. Guaranty
of Payment and Performance. Guarantor hereby guarantees to Creditors the full and punctual payment when due (whether at maturity,
by acceleration or otherwise) of the Notes and the performance of all liabilities, agreements and other obligations of Debtor under
the Notes, together with all costs of collection, compromise or enforcement, including without limitation reasonable attorneys’
fees incurred with respect to the Notes or this Guaranty, or with respect to a proceeding under the federal bankruptcy laws or
any insolvency, receivership, arrangement or reorganization law or an assignment for the benefit of creditors concerning Debtor
or Guarantor, together with interest on all such costs of collection, compromise or enforcement from the date arising (all the
foregoing, collectively the “Obligations”). This Guaranty is an absolute, unconditional and continuing guaranty
by Guarantor of the full and punctual payment and performance of the Obligations and not of their collectability only and is in
no way conditioned upon any requirement that Creditors first attempt to collect any of the Obligations from Debtor or resort to
any security or other means of obtaining their payment. Should Debtor default in the payment or performance of any of the Obligations,
the obligations of Guarantor hereunder shall become immediately due and payable to Creditors, without demand or notice of any nature,
all of which are expressly waived by Guarantor.

 

2. Unlimited
Guaranty. The liability of Guarantor hereunder shall be unlimited.

 

3. Waivers by
Guarantor; Creditors’ Freedom to Act. Guarantor agrees that the Obligations will be paid and performed strictly in accordance
with their terms regardless of any law, regulation or order now or hereafter in effect in any jurisdiction affecting any of such
terms or the rights of Creditors with respect thereto. Guarantor waives presentment, demand, protest, notice of acceptance, notice
of Obligations incurred and all other notices of any kind, all defenses that may be available by virtue of any valuation, stay,
moratorium law or other similar law now or hereafter in effect, any right to require the marshalling of assets of Debtor, and all
suretyship defenses generally. Without limiting the generality of the foregoing, Guarantor agrees to the provisions of any instrument
evidencing, securing or otherwise executed in connection with any Obligation and agrees that the obligations of Guarantor hereunder
shall not be released or discharged, in whole or in part, or otherwise affected by (i) the failure of Creditors to assert any claim
or demand or to enforce any right or remedy against Debtor; (ii) any extensions or renewals, or alteration of the terms, of any
Obligation or any portion thereof; (iii) any rescissions, waivers, amendments or modifications of any of the terms or provisions
of any agreement evidencing, securing or otherwise executed in connection with any Obligation; (iv) the substitution or release
of any entity primarily or secondarily liable for any Obligation; (v) the adequacy of any rights Creditors may have or other means
of obtaining repayment of the Obligations; (vi) failure to obtain or maintain a right of contribution for the benefit of Guarantor;
(vii) errors or omissions in connection with Creditors’ administration of the Obligations (except behavior constituting bad
faith); or (viii) any other act or omission that might in any manner or to any extent vary the risk of Guarantor or otherwise operate
as a release or discharge of Guarantor, all of which may be done without notice to Guarantor.

 

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4. Unenforceability
of Obligations Against Debtor. If for any reason Debtor is under no legal obligation to discharge any of the Obligations, or
if any of the Obligations have become irrecoverable from Debtor by operation of law or for any other reason, this Guaranty shall
nevertheless be binding on Guarantor to the same extent as if Guarantor at all times had been the principal obligor on all such
Obligations. In the event that acceleration of the time for payment of the Obligations is stayed upon the insolvency, bankruptcy
or reorganization of Debtor, or for any other reason, all such amounts otherwise subject to acceleration under the terms of any
agreement evidencing, securing or otherwise executed in connection with any Obligation shall be immediately due and payable by
Guarantor.

 

5. Subrogation;
Subordination. Until the payment and performance in full of all Obligations and any and all obligations of Debtor to Creditors,
(a) Guarantor shall not exercise any rights against Debtor arising as a result of payment by Guarantor hereunder, by way of subrogation
or otherwise, and will not prove any claim in competition with Creditors in respect of any payment hereunder in bankruptcy or insolvency
proceedings of any nature; (b) Guarantor will not claim any set-off or counterclaim against Debtor in respect of any liability
of Guarantor to Debtor; and (c) Guarantor waives any benefit of and any right to participate in any collateral that may be held
by Creditors. The payment of any amounts due with respect to any indebtedness of Debtor now or hereafter held by Guarantor is hereby
subordinated to the prior payment in full of the Obligations. Guarantor agrees that after the occurrence of any default in the
payment or performance of the Obligations, Guarantor will not demand, sue for or otherwise attempt to collect any such indebtedness
of Debtor to Guarantor until the Obligations shall have been paid in full. If, notwithstanding the foregoing sentence, Guarantor
shall collect, enforce or receive any amounts in respect of such indebtedness, such amounts shall be collected, enforced and received
by Guarantor as trustee for Creditors and be paid over to Creditors on account of the Obligations without affecting in any manner
the liability of Guarantor under the other provisions of this Guaranty.

 

6.Representations
of Guarantor. Guarantor has full legal right, power and authority to enter into and perform the transactions contemplated by
this Guaranty without need for any approval or notice to any other person; this Guaranty evidences the legal, valid and binding
obligation of Guarantor enforceable in accordance with its terms; the execution, delivery and performance of this Guaranty will
not violate any law, regulation, order, judgment or decree or result in a default or acceleration of any obligation under, or give
rise to any obligation under, any agreement or instrument that would have a material adverse impact on Guarantor.

 

7. Guarantor’s
Non-Reliance. Guarantor warrants to and agrees with Creditors that Guarantor has adequate means to obtain from Debtor on a
continuing basis information concerning Debtor’s financial condition and affairs, and that accordingly Guarantor is not relying
on Creditors to provide such information at the date of executing this Guaranty or at any time thereafter.

 

8. Termination;
Restatement. This Guaranty is irrevocable and shall continue without limit of time. This Guaranty shall be reinstated if at
any time any payment made or value received with respect to an Obligation is rescinded or must otherwise be returned by Creditors
upon the insolvency, bankruptcy or reorganization of Debtor, or otherwise, all as though such payment had not been made or value
received.

 

9. Successors
and Assigns. This Guaranty shall be binding upon Guarantor, its successors and assigns, and shall inure to the benefit of and
be enforceable by Creditors and Creditors’ heirs, personal representatives and assigns.

 

10. Amendments
and Waivers. No amendment or waiver of any provision of this Guaranty or consent to any departure by Guarantor therefrom shall
be effective unless the same shall be in writing and signed by Creditors. No failure on the part of Creditors to exercise, and
no delay in exercising, any right hereunder, shall operate as a waiver thereof; nor shall any single or partial exercise of any
right hereunder preclude any other or further exercise thereof or the exercise of any other right.

 

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11. Notices.
Except as may be otherwise provided herein, all notices, requests, waivers and other communications made pursuant to this Guaranty
shall be in writing and shall be conclusively deemed to have been duly given only (a) when hand delivered to the other party,
or (b) the next business day (the second business day in the case of deliveries from the United States to a jurisdiction
outside of the United States or from a jurisdiction outside of the United States to the United States) after deposit with a national
(or international, as applicable) overnight delivery service with all charges prepaid, addressed to the parties as their addresses
set forth herein with next business day (or second business day, as applicable) delivery guaranteed, provided that the sending
party receives written confirmation of delivery from the delivery service provider. Notices given by facsimile transmission or
by electronic delivery shall not be effective until written confirmation has been received in accordance with Section 11(b) hereof.
A party may change or supplement the addresses set forth below for purposes of this Section 11 by giving the other party written
notice of the new address in the manner set forth above

 

12. Governing
Law; Venue. This Agreement been negotiated and consummated in the State of New York and shall be construed in accordance with,
and governed by the internal laws of, the State of New York without giving effect to any choice of law rule that would cause the
application of the laws of any jurisdiction other than the internal laws of the State of New York to the rights and duties of the
parties. All disputes and controversies arising out of or in connection with this Guaranty shall be resolved exclusively by the
state or federal courts located in the State of New York, and each party hereto agrees to submit to the jurisdiction of said courts
and agrees that venue shall lie exclusively with such courts.

 

13. Miscellaneous.
This Guaranty constitutes the entire agreement of Guarantor with respect to the matters set forth herein. This writing is intended
by the parties as a final, complete and exclusive expression of their guaranty agreement. No course of dealing, course of performance
or trade usage, and no parol evidence of any nature, shall be used to supplement or modify any terms. There are no conditions to
the full effectiveness of this Guaranty. The rights and remedies herein provided are cumulative and not exclusive of any remedies
provided by law or any other agreement, and this Guaranty shall be in addition to any other guaranty of the Obligations. The invalidity
or unenforceability of any one or more sections of this Guaranty shall not affect the validity or enforceability of its remaining
provisions. Captions are for the ease of reference only and shall not affect the meaning of the relevant provisions. The meanings
of all defined terms used in this Guaranty shall be equally applicable to the singular and plural forms of the terms defined.

 

 

 

* * * * *

 

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In
Witness Whereof, Guarantor has caused this Guaranty to be executed and delivered as a sealed instrument as of the date appearing
on page one.

 

 

	
        GUARANTOR

         

         

        __________________________

        Fouad Kallamni, Individually

         

         
	
        Acknowledged:

         

        DEBTOR

         

        OSO Beverages Corp.

         

         

         

        By: _____________________

        Fouad Kallamni

        President

 

    	4Exhibit 10.21

 

EMPLOYMENT AGREEMENT

 

This Employment Agreement
(this “Agreement”) is entered into effective as of May 12, 2014 (the “Effective Date”)
between Signal Genetics, Inc. (the “Company” or “SG”) and Robert Johnson (the “Executive”).
(Executive and the Company are referenced collectively herein as the “Parties.”)

 

RECITALS

 

WHEREAS, SG desires
to retain Executive as Chief Financial Officer to manage and oversee certain financial, accounting and administrative aspects of
the Company, and Executive desires to be employed by SG, in accordance with the terms and conditions of this Agreement; and

 

WHEREAS, the Parties
desire to set forth the terms and conditions upon which Executive will serve the Company.

 

NOW, THEREFORE, in
consideration of the above recitals and the mutual promises contained in this Agreement, the Parties agree as follows:

 

ARTICLE I.

 

EMPLOYMENT AND DUTIES
OF EXECUTIVE

 

1.1          Employment.
SG hereby employs Executive as Chief Financial Officer (“CFO”) and Executive accepts employment as CFO of SG
in accordance with the terms and conditions, and for the consideration, provided in this Agreement.

 

1.2          Employment
Period. The term of this Agreement shall commence on the Effective Date and shall continue on a month-to-month basis, subject
to the termination provisions set forth in this Agreement. On each one-month anniversary of the Effective Date after the Initial
Term, this Agreement and Executive’s employment shall be deemed to have been automatically extended for an additional one
(1) month term or such other period as mutually agreed to between the Parties unless either Party shall give written notice of
non-extension to the other Party at least ten (10) days before such anniversary date, or unless sooner terminated as provided in
this Agreement. Executive’s total term of employment with the Company under this Agreement during the Initial Term and any
extended term is collectively defined and referred to as the “Employment Period.”

 

1.3          Duties
of CFO.

 

1.3.1           During
the Employment Period, Executive (i) shall have the title of CFO, (ii) shall devote a majority of his time and attention to perform
his assigned duties and expend his best efforts, energies and skills to the business of the Company, and shall not engage in any
other activity that would materially interfere with the performance of his duties under this Agreement (provided that Executive
is permitted to continue to serve as senior tax accountant and controller at BSL Capital, Inc. to the extent that doing so does
not create any conflict of interest with Executive’s obligations or duties under this Agreement, or to engage in endeavors
related to the community, his faith, personal finances and effects and other charitable functions that do not materially interfere
with the performance of his duties hereunder), and (iii) shall perform such duties, and comply with all reasonable directions and
instructions of the Company’s Chief Executive Officer and Board of Directors.

 

    	 

    	 

    

 

1.3.2           During
the Employment Period, Executive will report directly to the Chief Executive Officer of the Company.

 

1.3.3           In
performing Executive’s duties hereunder, Executive shall in all material respects (i) abide by and comply with all applicable
laws, statutes, orders, rules, regulations, policies or guidelines promulgated, or judgments, decisions or orders entered, by any
court, arbitrator tribunal, administrative agency, or commission or other governmental or regulatory body, agency or instrumentality
or authority relating to the Company, (ii) abide by and adhere to the Company’s general policies and procedures as may be
adopted from time to time and (iii) conduct himself with respect to the Company with the prudence, care, dedication and skill as
would be manifested by one in the operation and management of his own assets and properties and in this regard shall owe a fiduciary
duty of prudence and dedication and care to the Company.

 

1.4          Principal
Employment.

 

1.4.1           Executive
agrees that his position as CFO of the Company shall be his principal employment and that he will not subordinate that position
to any other employment.

 

1.4.2           Executive
agrees that, during his employment with the Company, he will not engage in any matter whatsoever in a business or other endeavor
that would or might reasonably interfere with his duties or that is competitive with or similar in nature to the business of the
Company. Nonetheless, Executive shall have the right to own up to 3% of the outstanding shares of a publicly held company if such
shares are actively traded on a national stock exchange and he is not involved in the management of such company. Specifically
excluded from the restrictions set forth in this Section, and other provisions of this Agreement, is Executive’s ability
(as expressly permitted by the Company hereby) to continue to serve as senior tax accountant and controller at BSL Capital, Inc.

 

ARTICLE II.

 

COMPENSATION AND
BENEFITS

 

2.1          Compensation.
For all services rendered and required to be rendered by, covenants of and restrictions in respect to, Executive under this Agreement,
SG shall compensate Executive as follows:

 

A.           CFO
Base Salary. The Company shall pay to Executive during and with respect to the Employment Period, and Executive agrees to accept,
a monthly salary (“Base Salary”) equal to $19,167.00, payable on a semi-monthly basis in accordance with the standard
payroll practices of the Company.

 

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2.2          Reimbursement
of Expenses. During the Employment Period, Executive will be reimbursed for all reasonable business expenses, including travel
and entertainment expenses, incurred in the performance of his duties, responsibilities, or services performed for the Company,
upon presentation by Executive of the documentation, expense statements, vouchers, and such other supporting information as SG
may request or as may be consistent with SG practices. Executive will comply with the Company’s policies in incurring and
seeking reimbursement for such expenses.

 

2.3          No
other Compensation. Executive acknowledges no entitlement to any additional payment or consideration not specifically referenced
herein.

 

ARTICLE III.

 

TERMINATION

 

3.1          Termination.
In addition to the expiration of the Employment Period, this Agreement may be terminated in the following circumstances:

 

A.           Termination
For Cause. SG may, at any time during the Employment Period by written notice to Executive (the “Termination Notice”),
terminate the Employment Period for uncured “Cause” effective immediately. The Termination Notice shall specify the
reason for termination. In such an event, Executive’s sole remedy shall be to collect all unpaid Base Salary and all unreimbursed
expenses payable for all periods through the effective date of termination. Executive shall not be entitled to earn or accrue any
compensation or other amount from the Company after the effective date of termination. The foregoing amounts shall be paid on the
date of termination.

 

For purposes hereof,
“Cause” as utilized herein shall mean:

 

(i)          Expiration
of the term of this Employment Agreement;

 

(ii)         A
material breach by Executive of his fiduciary duty to SG that results in material harm to the Company;

 

(iii)        A
material breach by Executive of the terms of this Employment Agreement or any other agreement between Executive and SG, which remains
uncured for a period of ten (10) days following the receipt of written notice specifying the nature of the breach;

 

(iv)        The
willful commission by Executive of any act of embezzlement, fraud, larceny or theft on or from SG;

 

(v)         Substantial
and continuing willful neglect or inattention by Executive of the duties of his employment, refusal to perform the lawful and reasonable
directives of the Company’s Chief Executive Officer and/or Board of Directors or the willful misconduct or gross negligence
of Executive in connection with the performance of such duties which remain uncured for a period of ten (10) days following the
receipt of written notice specifying the nature of the breach:

 

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(vi)        The
willful commission by Executive of any crime involving moral turpitude or a felony; and

 

(vii)       Executive’s
performance or omission of any act which, in the judgment of the Chief Executive Officer and/or the Board of Directors, if known
to the customers, clients, stockholders or any regulators of SG, would have a material adverse impact on the business of SG.

 

B.           Termination
Without Cause. The Company may terminate this Agreement at any time for any reason, by delivering a written notice to Executive,
effective ten (10) days after Executive receives such notice in accordance with the terms hereof. In such an event, Executive’s
sole remedy shall be to collect all unpaid Base Salary and all unreimbursed expenses payable for all periods through the effective
date of termination (the foregoing amounts shall be paid on the date of termination of Executive’s employment).

 

C.           Termination
by Executive for “Good Reason” or Without “Good Reason”. Executive shall have the right to terminate
his employment under this Agreement, and collect all unpaid Base Salary and all unreimbursed expenses payable for all periods through
the effective date of termination (the foregoing amounts shall be paid on the date of termination of Executive’s employment)
with or without “Good Reason” by the delivery of fifteen (15) days advance written notice to the Company.

 

For purposes hereof,
“Good Reason” as utilized herein shall mean:

 

(i)          the
Company has materially breached this Agreement and the Company has failed to cure or remedy such breach after 10-days written notice
from Executive;

 

(ii)         there
has occurred any material and substantial diminution or reduction in duties, Base Salary, title, health care coverage (but only
if such diminution is disproportionate to a diminution in health care coverage applicable to other employees of the Company), authority
or responsibilities of Executive, whether in scope or nature, and the Company has failed to cure or remedy such breach after fifteen
(15) days written notice from Executive; and

 

(iii)        the
Company has required that Executive perform any act or refrain from performing any act that would be in violation of applicable
law.

 

ARTICLE IV.

 

MISCELLANEOUS PROVISIONS

 

4.1          Notice.
All notices, requests, demands, consents, and other communications required or permitted to be given or made hereunder shall be
in writing and shall be deemed to have been duly given and received, (i) if delivered by hand, the day it is so delivered, (ii)
if mailed via the United States mail, certified or registered first class mail, postage prepaid, return receipt requested, five
business days after it is mailed, or (iii) if sent by a nationally recognized overnight courier for next business day delivery,
the business day after it is sent, to the Party to whom the same is so given or made, as follows: (a) to the Company, at its administrative
offices and (b) to Executive, at the address maintained on the personnel records of the Company. Either Party may change the address
to which notice is required to be sent by providing notice of the change of address in accordance with this Agreement.

 

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4.2          Headings.
All descriptive headings in this Agreement are inserted for convenience only and shall be disregarded in construing or applying
any provision of this Agreement.

 

4.3          Counterparts.
This Agreement may be executed in counterparts (including via e-mail with scan attachment or by facsimile transmission), and when
each Party has signed and delivered at least one such counterpart, each counterpart shall be deemed an original, and, when taken
together with other signed counterparts, shall constitute one Agreement, which shall be binding upon and effective as to all Parties.

 

4.4          Severability.
In the event that any term or provision of this Agreement, or part thereof, is held to be invalid, such invalidation shall not
affect the validity of the remainder of this Agreement. Further, the invalid provision shall be modified by the minimum amount
legally required to make the provision valid and enforceable and to carry out the purposes of this Agreement. Moreover, the remainder
of such provision and this Agreement, as the case may be, shall nevertheless remain in full force and effect.

 

4.5          Entire
Agreement. This Agreement contains the entire agreement and understanding among and between the Parties with respect to the
subject matter hereof, and supersedes any prior agreement and understanding among them with respect to the subject matter of this
Agreement. Except as otherwise provided herein, this Agreement cannot be changed or terminated except by an instrument in writing
signed by the Parties hereto. Any oral representations, modifications or amendments concerning this Agreement shall be of no force
or effect unless contained in a subsequent written modification signed by the Executive and a duly authorized representative of
the Company.

 

4.6          Personal
Services Contract. This contract is a personal services contract and Executive may not assign any portion of his responsibilities
under this Agreement. However, Executive shall have the right, after consultation with the Chief Executive Officer, to reasonably
delegate appropriate administrative duties to any person who is an employee of the Company.

 

4.7          Binding
on Successors. This Agreement shall be binding upon, and inure to the benefit of, each Party’s successors, transferees,
heirs and assigns, only to the extent that such is permitted by this Agreement. It shall be binding on the Company and its officers,
directors, and employees and shall not be affected by any change of name, change of geographical location, change of form, or acquisition
by or merger with any other entity.

 

4.8          Indemnification.
The Company recognizes that the activities within the scope of Executive’s employment create the potential in some jurisdictions
of civil or even criminal actions being brought against Executive. To the fullest extent provided by applicable Delaware law and
the Company’s organizational and controlling documents, and consistent with any indemnification provided to other Company
executive employees under any applicable insurance policies, including its professional liability coverage for directors and officers
and for acts and omissions relating to employees’ administrative duties, the Company shall indemnify, defend, protect and
hold harmless Executive, from and against all claims, demands, causes of action, actions, suits, costs, damages, penalties, fines,
liabilities, losses and expenses, whether civil or criminal, including, without limitation, reasonable attorneys’ fees and
expenses, arising out of or resulting from the performance of Executive’s duties within the course and scope of Executive’s
employment with the Company.

 

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4.9          Confidentiality;
Disclosure of Information.

 

(a)          Executive
recognizes and acknowledges that he will have access to Confidential Information (as defined below) relating to the business or
interests of the Company or of persons with whom the Company may have business relationships. Except as permitted herein or as
may be approved by the Company from time to time, Executive will not during the Employment Period or for a period of 12 months
thereafter, use or disclose to any other person or entity, any Confidential Information of the Company (except as required by applicable
law or in connection with performance of Executive’s duties and responsibilities hereunder or to Executive’s legal
and financial advisors so long as such advisors agree to be bound by the terms and conditions of this Paragraph 4.9(a)). Executive
may disclose the existence of the obligations under this Paragraph 4.9(a) to future employers. If Executive is requested or becomes
legally compelled to disclose any of the Confidential Information, he, if permitted by applicable law, will give prompt notice
of such request or legal compulsion to the Company. The Company may waive compliance with this Paragraph 4.9(a) or will provide
Executive with legal counsel at no cost to Executive to seek an appropriate remedy; provided however Executive may disclose any
Confidential Information in the event notwithstanding all such efforts of the Company and such legal counsel if compelled by court
order to do so.

 

The term “Confidential
Information” shall mean information relating to the Company’s business affairs, proprietary technology, trade secrets,
patented processes, research and development data, know-how, market studies and forecasts, competitive analyses, pricing policies,
executive lists, employment agreements (other than this Employment Agreement), personnel policies (including compensation paid
to employees and consultants), the substance of agreements with patients, customers, suppliers, and others, marketing arrangements,
patient lists, customer lists, commercial arrangements, or any other information relating to the Company’s business which
is treated as confidential or proprietary by the Company in accordance with its policies. Notwithstanding the immediately preceding
sentence, the provisions of this Paragraph 4.9(a) shall not apply to any information that: (1) is in the public domain; (2) is
or becomes available to the public other than as a result of a disclosure by Executive in violation of this Paragraph 4.9(a); (3)
was available to Executive on a non-confidential basis prior to the date of this Employment Agreement; or (4) becomes available
to Executive on a non-confidential basis from a source other than the Company (other than through a known breach of a confidentiality
obligation). This obligation shall continue until such Confidential Information becomes publicly available, other than pursuant
to a breach of this Paragraph 4.9(a) by the Executive, regardless of whether the Executive continues to be employed by the Company.

 

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(b)          It
is further agreed and understood by and between the Parties to this Agreement that all “Company Materials,” which include,
but are not limited to, computers, computer software, computer disks, tapes, printouts, source, HTML and other codes, flowcharts,
schematics, designs, graphics, drawings, photographs, charts, graphs, notebooks, patient lists, customer lists, sound recordings,
other tangible or intangible manifestation of content, and all other documents whether printed, typewritten, handwritten, electronic,
or stored on computer disks, tapes, hard drives, or any other tangible medium, as well as samples, prototypes, models, products
and the like shall be the exclusive property of the Company and, upon termination of Executive’s employment with the Company,
and/or upon the written request of the Company, all Company Materials, including copies thereof, as well as all other property
of the Company then in Executive’s possession or control, shall be returned to and left with the Company.

 

4.10        Intellectual
Property: Definition. Intellectual Property means any of the following that are conceived of, developed, reduced to practice,
created, modified, or improved by Executive, either solely or with others, in whole or in part, in the course of, or as a result
of, the Executive’s employment by the Company in any capacity, whether at the Company’s place of business or otherwise,
and whether on the Company’s time or on the Executive’s own time: (i) writings (including notes, reports, manuals and
instructions), software, source code, algorithms, works and copyrightable subject matter and rights, title and interest in copyrights
and copyright registrations, (ii) rights, title and interest in know-how, technical information, processes, practices and systems,
whether or not protectable by patent, copyright or trade secret law, (iii) trademarks, trade names, service marks, emblems, logos,
symbols and insignia and rights with respect thereto, including registrations and registration rights, (iv) all developments, including
trade secrets of any kind, discoveries, improvements, and ideas directly relating to or useable in the Company business and (v)
licenses granted by third parties of rights to use any of the foregoing.

 

(a)          Intellectual
Property shall be the exclusive property of the Company, and Executive shall have no right, title, or interest in, or to, the Intellectual
Property. The Company shall have the sole and exclusive right, title, and interest in, and to, the Intellectual Property, which
right shall continue notwithstanding the cessation of Executive’s employment. Executive also hereby irrevocably waives any
“moral rights” that Executive may have in the Intellectual Property, and confirms that the Company shall have the right,
in addition to the other rights granted hereunder and notwithstanding the termination of Executive’s employment for any reason,
to make or have made, and own, enhancements, derivative works, and other modifications to any part of the Intellectual Property.

 

(b)          Executive
hereby assigns to the Company any right, title, and interest that Executive may have in, and to, the Intellectual Property in any
patent, copyright, industrial design, trademark registration, and any other similar right pertaining to the Intellectual Property
which Executive may have.

 

(c)          Executive
acknowledges that the assignments in (b) above are undertaken in part as a contingency against the possibility that any Intellectual
Property, by operation of law, may not be considered a work made for hire by the Executive for the Company. The Company and its
successors and assigns, shall have the right to obtain and hold in their own name all copyright registrations, patents, and other
evidence of rights that may be available for the Intellectual Property and/or any portion thereof. Executive further acknowledges
that all United States copyrights and all other intellectual property rights in the Intellectual Property (including any and all
patents that may issue with respect thereto) shall be exclusively owned by the Company and shall be considered “works made
for hire,” as such term is defined in the United States Copyright Act, by Executive for the Company.

 

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(d)          Executive
hereby covenants and binds Executive and Executive’s successors, assigns and legal representatives to cooperate fully and
promptly with the Company and its designees, successors, and assigns, at the Company’s reasonable expense, and to do all
acts necessary or requested by the Company and its designee, successors, and assigns, to secure, maintain, enforce, and defend
the Company’s rights in the Intellectual Property. Without limitation to the foregoing, Executive shall execute on demand,
and bind Executive and Executive’s successors, assigns and legal representatives, whether during Executive’s employment
or at any time following the cessation of Executive’s employment, to any applications, transfers, assignments, and other
documents as the Company may consider necessary for the purpose of: (i) obtaining, maintaining, vesting in, or assigning to, the
Company absolute title to, (ii) applying for, prosecuting, obtaining, or protecting, or (iii) maintaining, enforcing, and/or defending
the Company’s rights in, any patent, copyright, industrial design, trademark registration, or any other right pertaining
to the Intellectual Property in any countries in the world. Executive further agrees, and binds Executive and Executive’s
successors, assigns and legal representatives, to cooperate fully and assist the Company in every way possible in the application
for, or prosecution of, such rights pertaining to the Intellectual Property and not developed during Executive’s employment
with the Company.

 

(e)          Executive
shall promptly disclose to the Company any patent application filed within one (1) year after termination of Executive’s
employment with the Company. Executive shall have the burden of proving that any invention that relates, or pertains, to the Company’s
business, and which is conceived less than one (1) year after the effective date of the termination of Executive’s employment
relationship, was in fact made after such termination and not developed during Executive’s employment with the Company. Executive
agrees that, during his employment with the Company, he will disclose to the Company all ideas, proposals, and plans, invented
or developed by him, which relate to the business of the Company and its subsidiaries.

 

4.11        Non-Solicitation.
Executive acknowledges that the Company has invested substantial time, money and resources in the development and retention of
its Confidential Information (including trade secrets), customers, patients, accounts and business partners, and further acknowledges
that, during the course of Executive’s employment with the Company, Executive will have access to the Company’s Confidential
Information (including trade secrets), and will be introduced to existing and prospective customers and patients that are being
targeted, vendors, accounts and business partners of the Company. Executive acknowledges and agrees that any and all “goodwill”
associated with any existing or prospective customer or patient that is being targeted, vendor, account or business partner belongs
exclusively to the Company, including, but not limited to, any goodwill created as a result of direct or indirect contacts or relationships
between Executive and any existing or prospective customers or patients that are being targeted, vendors, accounts or business
partners. Additionally, the Parties acknowledge and agree that Executive possesses skills that are special, unique or extraordinary
and that the value of the Company depends upon his use of such skills on its behalf. Executive acknowledges that as a result of
the foregoing the restrictions contained herein and elsewhere in this Agreement are reasonably necessary to protect the Company
from unfair competition by the Executive.

 

    	-8-

    	 

    

 

In recognition of this,
Executive covenants and agrees that:

 

(a)          During
Executive’s employment with the Company and for one year thereafter, Executive may not directly or indirectly induce, attempt
to induce, solicit, attempt to solicit or encourage any employee, consultant, or contractor to leave the employment or engagement
with the Company or any affiliate of the Company.

 

(b)          During
Executive’s employment with the Company and for one year thereafter, Executive may not, directly or indirectly, induce, attempt
to induce, solicit, attempt to solicit or encourage any customer, client, subscriber or supplier of the Company to change its relationship
with the Company, or interfere with the Company’s business, relationships or prospective relationships with any person or
entity that was or is expected to become a customer or client of the Company. As such, Executive agrees that he will not divert
or take advantage of any actual or potential business opportunities of the Company in which it has a current interest or is actively
pursuing.

 

4.12        Non-Disparagement;
Non-Disclosure. Executive and the Company hereby agree that during the Employment Period and at all times thereafter, neither
Executive nor the Company will make any public statement, or engage in any conduct, that is disparaging, derogatory, or otherwise
is a negative or false statement about the other Party or, in the case of the Company, about any of its executives, officers, directors,
or shareholders, including, but not limited to, any statement that disparages the products, services, finances, financial condition,
capabilities or any other aspect of the business of the Company and the capabilities of Executive. Notwithstanding any term to
the contrary herein, neither Executive nor the Company shall be in breach of this Paragraph 4.12 for the making of any truthful
statements under oath or in a judicial or other proceeding.

 

4.13        Representation.
Executive represents and warrants to the Company that (i) Executive is able to enter into this Agreement with the Company, and
Executive’s ability to enter into this Agreement and to fully perform Executive’s anticipated duties for the Company
is not limited or restricted by any agreements, understandings, instruments, orders, judgments or decrees to which Executive is
a party or by which Executive is bound and (ii) Executive’s performance of such duties for the Company will not directly
or indirectly violate any contractual or common law obligations he has or had to other employers or entities. Executive agrees
that he will not improperly use, disclose, or induce the Company to use any proprietary information or trade secrets of any former
or concurrent employer or other person or entity. Executive agrees that he will not bring onto the premises of the Company or transfer
onto the Company’s technology systems any unpublished document, proprietary information or trade secrets belonging to any
such employer, person or entity unless consented to in writing by both the Company and such employer, person or entity.

 

    	-9-

    	 

    

 

4.14        Applicable
Law. This Agreement shall be governed by, and construed and enforced in accordance with, the substantive and procedural laws
of the State of New York. Each Party hereto hereby irrevocably submits to the jurisdiction of the state and federal courts located
in New York County, New York, and waives any claim based upon forum non-conveniens or lack of jurisdiction.

 

[Remainder of Page Intentionally Left
Blank; Signature Page Follows]

 

    	-10-

    	 

    

 

 

IN WITNESS WHEREOF,
the Parties have executed this Agreement effective as of the date first written above.

 

	EXECUTIVE:	 	EMPLOYER:
	 	 	 
	Robert Johnson	 	Signal Genetics, Inc.
	 	 	 	 
	/s/ Robert Johnson	 	By:	/s/ Samuel D. Riccitelli
	 	 	Name:  Samuel D. Riccitelli
	5/12/14	 	Title:  Chief Executive Officer
	Date	 	 
	 	 	 
	 	 	May 12, 2014
	 	 	Date

 

    	-11-

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