Document:

<PAGE>   1

                                 AMENDMENT NO. 1
                                       TO
                             MASTER LEASE AGREEMENT
                     DATED SEPTEMBER 22, 2000 (THE "LEASE")
                                 BY AND BETWEEN
                        NEOTHERAPEUTICS, INC. ("LESSEE")
                                       AND
                    COMDISCO LABORATORY AND SCIENTIFIC GROUP,
                     A DIVISION OF COMDISCO, INC. ("LESSOR")

WHEREAS, Lessor and Lessee desire to enter into the Lease; and

WHEREAS, Lessor and Lessee desire to amend certain provisions of the Lease as
hereafter provided; and

WHEREAS, the Amendment shall be deemed to have been entered into
contemporaneously with and integrated into the terms and conditions of the
Lease.

NOW THEREFORE, for good and valuable consideration, Lessor and Lessee hereby
agree to amend the Lease as follows:

        1 Lessee agrees to maintain a financial status of all of the following
during the term of the Lease and any extension or renewal thereof.

        A. Cash or equivalents of not less than $5,000,000.00;

        2. In addition, Lessee agrees to provide Lessor with quarterly financial
statements within forty-five (45) days after the end of each fiscal quarter and
audited annual financial statements within one hundred twenty (120) days of the
end of each fiscal year.

        3. Failure of Lessee to maintain any one of the above at any time during
the Lease term and any extension or renewal thereof or the failure to make any
payment due under the Lease is an Event of Default under the Lease which Lessee
must, within ten (10) days, provide a Letter of Credit from a bank acceptable to
Lessor for one hundred percent (100%) of all rent then due or to become due
under the lease as of the date of the default. Along with the Letter of Credit,
Lessee shall also execute a Letter of Credit Agreement with Lessor. The Letter
of Credit and Letter of Credit Agreement shall be in a form identical to
Exhibits A & B attached and incorporated herein.

        4. Lessor shall also be entitled to any or all remedies or actions in
the event of default, as provided in the Lease, and this Amendment shall not be
construed to limit Lessor's rights in any way.

Except as set out herein, Lessor and Lessee hereby agree that the terms and
conditions of the Lease shall remain in full force and effect as entered into by
the parties on or prior to the date hereof.

NEOTHERAPEUTICS, INC.                  COMDISCO LABORATORY AND SCIENTIFIC GROUP,
as Lessee                              A DIVISION OF COMDISCO, INC.
                                       as Lessor

By:                                    By:
   ------------------------------          ----------------------------------

Title:                                 Title:
      ---------------------------             -------------------------------

Date:                                  Date:
      ---------------------------           ---------------------------------

<PAGE>   2

                                    EXHIBIT A

                              (ON BANK LETTERHEAD)

{DATE)

BENEFICIARY:
Comdisco Laboratory and Scientific Group,
a division of Comdisco, Inc., or Transferee
6111 N. River Road
Rosemont, IL 60018

Gentlemen:

We hereby establish our Irrevocable Standby Letter of Credit No. in your favor
for account of , for a sum not to exceed AND /100 DOLLARS ($) available by your
draft drawn at sight on us -

Draft must be accompanied by: Your statement signed by an officer of Comdisco
Laboratory and Scientific Group, a division of Comdisco Inc. certifying that
NeoTherapeutics, Inc. has defaulted under that certain Master Lease Agreement
dated September 22, 2000 between NeoTherapeutics, Inc. and Comdisco Laboratory
and Scientific Group, a division of Comdisco, Inc., and the original of this
Letter of Credit.

This Letter of Credit expires __________________. All drafts drawn hereunder
must be present for payment at
_________________________________________________________ our office at on or
before that date.

It is a condition of this Irrevocable Standby Letter of Credit that it shall be
deemed automatically extended without amendment for one (1) year from the
present or any future expiration date hereof but not beyond end of lease term.
Should we elect not to renew this Standby Letter of Credit, we shall notify you
of such election 45 days prior to any such date. All notices shall be in
writing, sent by certified mail, return receipt requested and addressed to you
at the above address, ATTENTION: Credit Manager. Notwithstanding receipt by you
of such notice, you may draw hereby by means of your draft on us at sight
accompanied by the documents required herein, until such expiration date.

This Letter of Credit may be transferred by you at any time and such transfer
shall be deemed effective and binding on us upon receipt of written notice of
such transfer from you when accompanied by the original of this Letter of
Credit.

We hereby agree that drafts drawn strictly in compliance with the terms of this
credit and any amendments thereto shall meet with due honor upon presentation at
our office at

                                            --------------------------------
                                            Title

<PAGE>   3

                                    EXHIBIT B

                                LETTER OF CREDIT
                                    AGREEMENT

Stand-by Letter of Credit Agreement dated _______________________, by and
between NeoTherapeutics, Inc. ("Lessee") located at 157 Technology Drive,
Irvine, CA 92618 and Comdisco Laboratory and Scientific Group, a division of
Comdisco, Inc. ("Lessor") with offices at 6111 N. River Road, Rosemont, IL
60018.

WHEREAS, Lessee has requested that Lessor lease various equipment, as further
described in the Lease (the "Equipment"), to Lessee; and

WHEREAS, Lessor has agreed to lease the Equipment to Lessee upon the condition
that an Irrevocable Stand-by Letter of Credit shall be outstanding for the full
term of the Master Lease Agreement to additionally secure Lessee's performance
under the Lease.

NOW THEREFORE, in consideration of and as an inducement to Lessor to lease the
Equipment to Lessee, the parties hereto agree as follows:

        1. Lessee and Lessor have entered or shall enter into a Master Lease
Agreement and one or more Schedules thereunder for leasing the Equipment,
(together the "Lease"), all of which shall be covered by the terms of this
Agreement.

        2. Concurrently with the execution for this Agreement, Lessee shall
cause to be delivered to Lessor in the form attached hereto as Exhibit A, an
Irrevocable Stand-by Letter of Credit issued by a bank acceptable to Lessor,
which Letter of Credit shall been the amount of AND /100 dollars ($) ("Letter of
Credit") and shall be outstanding until __________________, with annual renewals
until end of lease term.

        3. Receipt by Lessor of notice that the Letter of Credit will not be
renewed on any expiration date, as provided therein, shall constitute a material
default by Lessee under the terms and conditions of the Lease. Lessor shall then
have the right to draw upon the Letter of Credit up to its full amount and to
apply the proceeds as set out in paragraph 4, below, unless at least thirty (30)
days prior to said expiration date Lessee replaces the Letter of Credit with a
Letter of Credit which has been issued by a bank acceptable to Lessor and has
the same terms and conditions as the replaced Letter of Credit.

        4. Upon the occurrence of any Event of Default under the Lease which
shall include Amendment 00 1, and at any time while a default is continuing,
Lessor shall have the right to draw upon the Letter of Credit up to its full
amount and to apply the proceeds thereof first to any reasonable costs and
expenses incurred by Lessor in the enforcement of the terms of the Lease and the
exercise of its rights and remedies, then to the unpaid balance of all sums
payable under the Lease, whether by acceleration or otherwise, with any excess
proceeds being refundable to Lessee, and Lessee remaining liable for any
deficiency.

        5. Waiver by Lessor of a default shall not constitute a continuing
waiver of default, of the same provision or any other provision of the Lease.
Additionally, failure of Lessor to draw upon the Letter of Credit at any time
shall not be construed as a waiver of Lessor's right to draw upon the Letter of
Credit as herein set forth at any other time.

        6. The exercise by Lessor of its rights under this Agreement shall be
deemed to be in addition to and not in lieu of any other rights and remedies of
Lessor under the Lease, or any other document relating to the Lease and shall
not be construed in any manner to represent satisfaction of the obligations of
Lessee under or with respect to the Lease.

<PAGE>   4

IN WITNESS WHEREOF, the parties have caused this Agreement to be executed as of
the date set forth above.

NEOTHERAPEUTICS, INC.                  COMDISCO LABORATORY AND SCIENTIFIC GROUP,
as Lessee                              A DIVISION OF COMDISCO, INC.
                                       as Lessor

By:                                    By:
   ------------------------------          ----------------------------------

Title:                                 Title:
      ---------------------------             -------------------------------

Date:                                  Date:
      ---------------------------           ---------------------------------

                                       2
<PAGE>   5

                                  DRAW REQUEST
                                                            Letter of Credit No.

[date]

Attention:     Letter of Credit Department

Gentlemen:

        The undersigned hereby draws on Irrevocable Standby Letter of Credit No.
dated (the "Letter of Credit") issued by you in our favor. Any capitalized term
used herein and not defined shall have its respective meaning as set forth in
the Letter of Credit.

        In connection with the drawing, the undersigned hereby certifies that:

        (1) Pursuant to Equipment Schedule No. SG-0 1, an Event of Default has
occurred thereunder and we are making this drawing under the Letter of Credit
pursuant to the Schedule.

        (2) The amount of this request is $, which amount does not exceed the
current Letter of Credit amount.

        (3) The date here is not after the Expiration Date.

        IN WITNESS WHEREOF, the undersigned has executed and delivered this
request on this day of.

                                       COMDISCO LABORATORY AND SCIENTIFIC GROUP,
                                       A DIVISION OF COMDISCO, INC.

                                       By:
                                          -------------------------------

                                       Title:
                                             ----------------------------<PAGE>   1

                                                                  17-SL40544-00

                           EQUIPMENT SCHEDULE NO. SG01

                         DATED AS OF SEPTEMBER 22, 2000

    TO MASTER LEASE AGREEMENT DATED AS OF SEPTEMBER 22,2000 ("MASTER LEASE")

<TABLE>
<S>                                               <C>
LESSEE: NEOTHERAPEUTICS, INC.                     LESSOR:   COMDISCO LABORATORY AND SCIENTIFIC
                                                            GROUP, A DIVISION OF COMDISCO, INC.

ADDRESS FOR LEGAL NOTICES:                        ADDRESS FOR ALL NOTICES:

157 Technology Drive                              6111 North River Road
Irvine, California 92618                          Rosemont, Illinois 60018

ATTN:   Corporate Secretary                       Attn:   Contracts Administration

ADDRESS FOR ADMINISTRATIVE CORRESPONDENCE:        ADDRESS FOR INVOICES:

157 Technology Drive                              157 Technology Drive
Irvine, California 92618                          Irvine, California 92618

ATTN: Sam Gulko                                   ATTN: Sam Gulko
PHONE: 949/788-6700 ext. 209
FAX: 949/

LOCATION OF EQUIPMENT:                            LESSEE REFERENCE NO:
                                                                      --------------------------
                                                                           (24 digits maximum)
157 Technology Drive
Irvine, California 92618

ATTN: Sam Gulko                                   INITIAL TERM/
PHONE: 949/788-670 ext. 209                       RENT INTERVAL: 12 Quarters
                                                  LEASE RATE FACTOR:    1st Qtr @ .28
                                                                        2nd-12th Qtr @ .0707
</TABLE>

EQUIPMENT (AS DEFINED BELOW):

<TABLE>
<CAPTION>
    ITEM                                  MACHINE       MODEL/                   SERIAL
     NO.        QTY.          MFG.         TYPE        FEATURE   DESCRIPTION     NUMBER
    ----        ----          ----        -------      -------   -----------     ------
<S>             <C>           <C>         <C>           <C>      <C>             <C>

</TABLE>

GROUP I EQUIPMENT: Installed Laboratory and Scientific Equipment described on
Attachment A.

GROUP II EQUIPMENT: New Laboratory and Scientific Equipment comprised of
equipment types described under Group I Equipment, which are supplied from
outside vendors.

<PAGE>   2

GROUP III EQUIPMENT: Laboratory and Scientific Equipment comprised of equipment
types described under Group I Equipment, which are supplied, from Lessor's
inventory pursuant to Section 7 hereof.

NOTICE PERIOD: The Notice Period will be not less than one hundred eighty (180)
days nor more than twelve (12) months prior to the expiration of the Initial
Term, or any extension thereof. In order for the notice to be effective, a
notification by Lessee to Lessor must be accompanied by a letter from the
manufacturer representing that when the Equipment is returned to Lessor it will
be eligible for continued maintenance by a new end user. If Lessee gives proper
written notice of termination but fails to return the Equipment on the
expiration date of the Initial Term, or any extension thereof, the Schedule will
continue in full force and effect and Lessee will be required to provide an
additional sixty (60) days written notice of termination. Such termination will
be effective at the end of the quarter in which the last day of the sixty (60)
day notice requirement occurs. The Rent will continue at the current rate until
the effective date of written notice of termination and the Equipment is
properly returned.

SPECIAL TERMS: The following additional terms are a part of this Equipment
Schedule. The terms and conditions of the Master Lease Agreement as they pertain
to this Equipment Schedule are modified and amended as follows:

1.      EQUIPMENT - MULTIPLE DELIVERY

        It is understood that the Equipment to be leased is a combination of (i)
        Equipment purchased from Lessee and leased back to Lessee ("Group I
        Equipment'); (ii) Equipment purchased from the Equipment manufacturer or
        retail vendor ("Group II Equipment'); and (iii) Equipment supplied from
        Lessor's inventory ("Group III Equipment'). For purposes of this
        Schedule the terms "Group I Equipment", "Group II Equipment" and "Group
        III Equipment') are collectively referred to as the "Equipment".

        Lessor's obligation to lease the Equipment under this Schedule applies
        to Group I Equipment, Group II Equipment and Group III Equipment (but
        not to attachments or upgrades to the Equipment, leasehold improvements,
        construction costs, implementation fees, and application software fees)
        up to an aggregate `purchase price of $2,500,000.00.

        During the period from August 25, 2000 to January 31, 2001 ("Commitment
        Period'), (a) Lessee will provide to Lessor for each item of Group H
        Equipment and Group III Equipment, either Commencement Certificates or
        vendor invoices approved for payment by Lessee ("Invoices"), and (b)
        Lessor will make payment to Lessee for each item of Group I Equipment to
        be leased hereunder.

        With respect to Group I and Group H Equipment, Lessee acknowledges it is
        entitled to the warranties and indemnities, remedies and limitations
        provided by the Equipment manufacturer or vendor and may communicate
        directly with such manufacturer or vendor to receive an accurate and
        complete copy thereof. If the cost or configuration of the Equipment
        changes, Lessor may adjust the Lease Rate Factors to reflect these
        additional costs or related expenses.

2.      COMMITMENT FEE

        In consideration of Lessor entering into this Schedule with Lessee,
        Lessee agrees to pay to Lessor a commitment fee in the amount of
        $11,250.00 ("Commitment Fee") based upon the aggregate purchase price of
        the Equipment from Equipment Group I and 11 to be leased under this
        Schedule. The Commitment Fee will be due and payable upon receipt of
        Lessor's invoice. Lessor will apply the Commitment Fee to the first
        quarterly rental payment under each Summary Schedule for this Schedule,
        and such allocation will be equal to one percent (II/o) of the total
        purchase price of the Equipment leased under a Summary Schedule.

3.      COMMENCEMENT DATE

        The Commencement Date for each item of Group II Equipment and Group HI
        Equipment will be the day on which the Equipment is installed and
        qualified for a commercially available manufacturer's standard
        maintenance contract or warranty coverage, if available. Lessee agrees
        to confirm the Commencement Date by providing Lessor with either the
        Invoices containing the Equipment location, description, serial number.
        and cost, the Commencement Date and Lessee's signature. or a
        Commencement Certificate in the form provided by Lessor, within ten (10)
        days of the Commencement Date. The Commencement Date for

                                       5
<PAGE>   3

        each item of Group I Equipment will be the date Lessor tenders payment
        of the purchase price for the Group I Equipment. Lessee will be deemed
        to accept the Group H Equipment on the Commencement Date.

        Notwithstanding anything to the contrary contained herein, during the
        interim period from the Commencement Date through but not including the
        first day of the start of the Initial Term, Lessee's rental obligations
        for each item of Equipment shall be equal to the daily Lease Rate Factor
        of .001012% multiplied by the acquisition cost for such item of
        Equipment multiplied by the number of days in the interim period.

4.      SUMMARY SCHEDULE

        Lessor will summarize all Invoices and/or Commencement Certificates
        received for the Group II Equipment, and all payments made by Lessor for
        the Group I Equipment, in the same calendar quarter into a Summary
        Schedule in the form attached to this Equipment Schedule as Exhibit I.
        Lessor will summarize all Commencement Certificates received for the
        Group III Equipment in the same calendar quarter into a separate Summary
        Schedule. The Initial Term for all items of Equipment will begin on the
        first day of the calendar quarter following the Commencement Date.
        Lessee agrees that for administrative purposes, including without
        limitation, invoicing of Rent and taxes and assignment of an identifying
        lease number, Lessor may administer the Summary Schedule as if it
        constituted a separate Equipment Schedule. Alternatively, if Lessor
        requests Lessee to execute a Summary Schedule, Lessee will have an
        appropriate official of Lessee execute and promptly return the Summary
        Schedule to Lessor. Executed Summary Schedules will incorporate the
        terms and conditions of the Master Lease and this Equipment Schedule and
        will constitute a separate Equipment Schedule.

5.      ADVERSE CHANGE

        If Lessee defaults or there is a material adverse change as reported by
        the Lessee in an 8K filing with the Securities and Exchange Commission
        ("SEC'), for subsequent Summary Schedules, Lessor, at its option with
        prior written notice to Lessee, will be relieved of its obligations to
        lease Equipment for which Lessor has not received Invoices or
        Commencement Certificates from Lessee prior to the date of such, notice.

6.      INTEREST RATE ADJUSTMENT

        In the event the Commencement Date for all items of Equipment to be
        leased hereunder is after August 31, 2000, the following will apply. The
        Lease Rate Factors set forth in this Schedule have been calculated, in
        part, based on the 3-year U.S. Treasury Constant Maturity of 6.06% as
        set forth in the Federal Reserve Statistical Release H. 15 ("Treasury
        Rate"). If on the last Commencement Date for all items of Equipment to
        be leased hereunder, there is a change in Treasury Rate in excess of 10
        basis points, the effective lease rate of % will be adjusted one basis
        point for each basis point change in the Treasury Rate. Additionally, if
        there is an adverse change in Lessee's credit standing prior to the
        Commencement Date for all items of Equipment to be leased hereunder, the
        Lease Rate Factors may be adjusted accordingly.

7.      GROUP III EQUIPMENT - SUPPLIED FROM LESSOR'S INVENTORY

        It is anticipated by Lessor and Lessee that at least fifty-five percent
        (55%) of the acquisition cost of the Equipment to be leased hereunder
        will be comprised of Group III Equipment. Lessee will provide Lessor
        with a ninety (90) day forecast of proposed Equipment acquisitions, with
        updates provided to Lessor every thirty (30) days. Lessor agrees it will
        use commercially reasonable best efforts to supply Group III Equipment,
        and Lessee agrees it will use commercially reasonable best efforts to
        accept Lessor's offer to supply Group III Equipment hereunder. Lessor
        will notify Lessee of Group III Equipment availability and the pricing
        of such Group III Equipment via facsimile transmission. Lessee will
        respond to Lessor's offer within a reasonable time frame via facsimile
        transmission by accepting or rejecting Lessor's offer. If Lessor's offer
        is accepted, the Group III Equipment will be supplied to Lessee in
        accordance with the terms of the offer and this Schedule. For purposes
        of determining the Quarterly Rent for an item of Group III Equipment,
        the Lease Rate Factor(s) set forth in this Schedule will be applied to
        the acquisition cost of the Group III Equipment as set forth in Lessor's
        offer.

                                       6
<PAGE>   4

8.      EQUIPMENT PROCUREMENT CHARGES (PROGRESS PAYMENTS)

        It is the agreement of the parties that due to the Equipment vendor's
        requirement that progress payments be paid prior to the Commencement
        Date ("Progress Payments"), all terms and conditions of this Equipment
        Schedule will be applicable to the Equipment except the Lessee's rental
        obligations. Notwithstanding the foregoing, Lessee agrees to pay Lessor
        "Equipment Procurement Charges" equal to a daily lease rate factor of
        .001012 multiplied by the aggregate of the Progress Payments paid by
        Lessor for each day from the date Progress Payments are made by Lessor
        until the Commencement Date. Lessee will authorize each Progress Payment
        prior to Lessor's payment by acknowledging such approval on the face of
        the invoice(s). Accrued Equipment Procurement Charges are payable within
        30 days of the date of Lessor's invoice.

        If Lessee rejects the Equipment prior to the Commencement Date pursuant
        to the purchase agreement with the Equipment vendor or if Lessee is in
        default of this Equipment Schedule, then this Equipment Schedule will
        terminate and Lessee will (i) reimburse Lessor for all amounts paid by
        Lessor for the purchase of the Equipment and (ii) pay all Equipment
        Procurement Charges due through the date of termination. Upon payment of
        all amounts due and owing by Lessee, Lessor will transfer to Lessee all
        of Lessor's interest in the Equipment and under any purchase agreement.

9.      RENEWAL OPTION (FAIR MARKET RENTAL VALUE)

        So long as no Event of Default shall have occurred, Lessee shall have
        the right to extend the Initial Term of this Schedule by giving Lessor
        at least one hundred eighty (180) days written notice prior to the
        expiration of the Initial Term, provided, however, this Schedule shall
        continue in effect following the extended period until terminated by
        either party upon not less than one hundred eighty (180) days prior
        written notice, which notice shall be effective the first of the month
        following receipt. The rent required to be paid during the extended
        period shall be based on the Fair Market Rental Value of the Equipment.
        Unless otherwise agreed in writing between the parties, this option
        shall not apply to add-ons or upgrades to the Equipment leased
        hereunder. Fair Market Rental Value shall be defined as the amount which
        would be obtainable at the commencement of the extended Initial Term in
        an arm's-length transaction between an informed and willing lessee/user
        leasing the Equipment in place for its originally intended use for the
        proposed lease term, and an informed and willing lessor/dealer under no
        compulsion to lease.

10.     PURCHASE OPTION (FAIR MARKET VALUE)

        So long as no Event of Default shall have occurred and is continuing
        hereunder, and upon at least one hundred eighty (180)days prior written
        notice to Lessor, Lessee will have the option at the expiration of the
        Initial Term of this Schedule to purchase all, but not less than all, of
        the Equipment for an amount equal to the Fair Market Value of the
        Equipment (plus any taxes applicable at time of purchase) on the date of
        the expiration of the Initial Term (the "Purchase Date"), payable to
        Lessor by the Purchase Date. Title to the Equipment will automatically
        pass to Lessee on the Purchase Date, provided Lessee has paid the full
        purchase price.

11.     RETURN OPTION

        In the event that Lessee does not elect the "Purchase Option" or
        "Renewal Option" contained herein, Lessee will return the Equipment to
        Lessor upon termination of the Schedule in accordance with the "Delivery
        and Return of Equipment" provision.

12.     ELECTRONIC FUNDS DEBIT AUTHORIZATION

        This Equipment Schedule is contingent upon Lessee authorizing Lessor, or
        Lessor's assigns, to institute electronic funds transfer debit
        instructions against Lessee's bank account using the Automated Clearing
        House funds-transfer systems in order to make payment to Lessor, or
        Lessor's assigns, for any and all of Lessee's payment obligations when
        due under the Master Lease Agreement and this Equipment Schedule. Lessee
        agrees to accurately complete, execute, and return to Lessor an
        Electronic Funds Debit Authorization Agreement provided by Lessor
        substantially in the form of Attachment I hereto. Lessor and Lessee
        agree that Lessor's electronic debit amount will not exceed amount
        stated on Lessor's Invoice.

                                       7
<PAGE>   5

13.     RENT ADJUSTMENT

        If Lessee fails to give the proper written notification to terminate
        this Equipment Schedule, or if the Equipment has not been returned to
        Lessor in accordance with the terms of the Master Lease, the Initial
        Term will automatically extend on a quarter to quarter basis at a
        quarterly lease rate factor .091036 until proper written notification of
        termination is received by Lessor and the Equipment is returned in
        accordance with the terms of the Master Lease.

14.     LESSOR'S ELECTION

        Lessee represents that it has paid all California sales tax due on the
        cost of that portion of the Equipment to be installed in California and
        agrees to provide evidence of such payment to, Lessor. As a result of
        the election, Lessor agrees that it will not invoice Lessee for use tax
        on the monthly rental payments for the Equipment. Lessee understands
        that this is an irrevocable election to measure the tax by the Equipment
        cost and cannot be changed except prior to installation of the
        Equipment.

MASTER LEASE: This Equipment Schedule is issued pursuant to the Master Lease
identified on page 1 of this Equipment Schedule. All of the terms and conditions
of the Master Lease are incorporated in and made a part of this Equipment
Schedule as if they were expressly described in this Equipment Schedule, and
this Equipment Schedule constitutes a separate lease for the Equipment. The
parties reaffirm all of the terms and conditions of the Master Lease (including,
without limitation, the representations and warranties set forth in the Master
Lease) except as modified by this Equipment Schedule. This Equipment Schedule
may not be amended or rescinded except by a writing signed by both parties.

NEOTHERAPEUTICS, INC.                  COMDISCO LABORATORY AND SCIENTIFIC GROUP,
as Lessee                              A DIVISION OF COMDISCO, INC.
                                       as Lessor

By:                                    By:
   ------------------------------          ----------------------------------

Title:                                 Title:
      ---------------------------             -------------------------------

Date:                                  Date:
      ---------------------------           ---------------------------------

CER
CLSG-ES (NML) form 07/00

                                       8

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00024-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00024-of-00352.parquet"}]]