Document:

tcon-ex1024_1335.htm

Exhibit 10.24

[***] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

 

Amendment One to License and Option Agreement

 

This Amendment One to License and Option Agreement (the “Amendment”) is effective as of January 15, 2019 (the “Amendment Effective Date”), by and between Janssen Pharmaceutica N.V. (“Janssen”) and TRACON Pharmaceuticals, Inc., a Delaware corporation (“Licensee”).  Each of Janssen and Licensee is sometimes referred to herein individually as a “Party” and collectively as the “Parties.”

WHEREAS, Janssen and Licensee are parties to that certain License and Option Agreement, effective as of September 27, 2016 (the “Agreement”), pursuant to which Janssen granted to Licensee an exclusive, worldwide license under certain Janssen technology and intellectual property rights to develop, manufacture and commercialize any AR Mutant Compound or NIK Compound (each as defined in the Agreement), and any product containing an AR Mutant Compound or NIK Compound, on the terms and conditions set forth in the Agreement; and

WHEREAS, the Parties now desire to amend the Agreement, in accordance with Section 13.8 thereof, to decrease the number of patients necessary to satisfy the conditions set forth in the definition of “AR Mutant POC Trial.”

Now, Therefore, in consideration of the mutual promises and covenants set forth below and other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the Parties hereby agree as follows:

	
1.
	
Amendment of the Agreement

The Parties hereby agree to amend the terms of the Agreement as provided below, effective as of the Amendment Effective Date.  Except to the extent the Agreement is explicitly amended by this Amendment, the Agreement will remain in full force and effect in accordance with its terms.  Capitalized terms used in this Amendment that are not otherwise defined herein shall have the meanings such terms are given in the Agreement.

Section 1.10 of the Agreement is hereby deleted and replaced in its entirety with the following:

“1.10.AR Mutant POC Trial” means the first Clinical Trial of the AR Mutant Product containing the AR Mutant Compound set forth on Schedule AR Mutant Compound of the Schedule Letter as the only active ingredient that satisfies the following criteria: (a) such Clinical Trial has [***]; and (b) such Clinical Trial has [***]

 

1.

 

[***] = Certain Confidential Information Omitted

 

 

 

[***].  For purposes of this definition, [***] means that [***].”

	
2.
	
Miscellaneous

2.1Full Force and Effect.  This Amendment amends the terms of the Agreement and is deemed incorporated into the Agreement.  The provisions of the Agreement, as amended by this Amendment, remain in full force and effect.  

2.2Entire Agreement.  The Agreement, as amended by this Amendment, constitutes the entire agreement, both written and oral, between the Parties with respect to the subject matter hereof, and any and all prior agreements with respect to the subject matter hereof, either written or oral, expressed or implied, are superseded hereby, merged and canceled, and are null and void and of no effect.

2.3Counterparts. This Amendment may be executed in one or more counterparts, each of which will be an original and all of which together will constitute one instrument.

 

[Signature Page Follows]

2.

[***] = Certain Confidential Information Omitted

 

In Witness Whereof, the Parties have executed this Amendment as of the Amendment Effective Date.

Janssen PHARMACEUTICA N.V.

 

 

By:/s/ L. Verbeeck                                       

 

Name:L. Verbeeck                                             __________

 

Title:Member of Management Board Janssen Pharmaceutica N.V.

 

 

Janssen PHARMACEUTICA N.V.

 

 

By:/s/ Bart Van WaeyenBerge                     

 

Name:Bart Van WaeyenBerge                         

 

Title:General Manager                                         

 

 

TRACON PHARMACEUTICALS, INC.

 

 

By:/s/ Charles Theuer, M.D., Ph.D.                

 

Name:Charles Theuer, M.D., Ph.D.                     

 

Title:   CEO                                                            

 

 

 

 

[Signature Page to Amendment One to License and Option Agreement]Exhibit 10.22

    

     

    

    DATED: 27 NOVEMBER 2018

    

    

    (1)   Tronox Sands Holdings Pty Limited

    

    

    (2)   Tronox Limited

    

    

    (3)   Exxaro Resources Limited

    

    

    (4)   Tronox KZN Sands Proprietary Limited

    

    

    (5)   Tronox Mineral Sands Proprietary Limited

    

    

    	
            AMENDMENT AGREEMENT TO

            SHAREHOLDERS' AGREEMENT

            RELATING TO

            TRONOX KZN SANDS

            AND

            TRONOX MINERAL SANDS

          

    

    

    
      
        

    

    
    

    

    DATED: 27 NOVEMBER 2018

    

    

    PARTIES

    

    

    
      
        	(1)	
                TRONOX SANDS HOLDINGS PTY LIMITED (ACN 154 709 332), an Australian proprietary
                    company limited by shares, registered office is at Lot 22 Mason Road, Kwinana Beach WA 6167 Australia (the "Australian Holdco");

              

      

    

    

    

    
      
        	(2)	
                TRONOX LIMITED (ACN 154 709 332), a company incorporated and existing under the
                    laws of the State of Western Australia, registered office is at Lot 22 Mason Road, Kwinana Beach WA 6167 Australia ("Tronox");

              

      

    

    

    

    
      
        	(3)	
                EXXARO RESOURCES LIMITED (registration number 2000/011076/06), a public company
                    with limited liability duly incorporated in the Republic of South Africa, whose registered office is at Roger Dyason Road, Pretoria West, 0183 South Africa ("Exxaro");

              

      

    

    

    

    
      
        	(4)	
                TRONOX KZN SANDS PROPRIETARY LIMITED (formerly known as Exxaro Sands Proprietary
                    Limited) (registration number 1987/001627/07), a private company with limited liability duly incorporated in the Republic of South Africa whose
                    registered office is at Riverfalls Officepark Wild Pear 262 Rose Avenue, Doringkloof Centurion Gauteng, 0157 South Africa ("Tronox KZN Sands"); and

              

      

    

    

    

    
      
        	(5)	
                TRONOX MINERAL SANDS PROPRIETARY LIMITED (formerly known as Exxaro TSA Sands
                    Proprietary Limited) (registration number 1998/001039/07), a private company with limited liability duly incorporated in the Republic of South
                    Africa whose registered office is at Riverfalls Officepark Wild Pear 262 Rose Avenue, Doringkloof Centurion Gauteng, 0157 South Africa ("Tronox Mineral
                      Sands").

              

      

    

    

    

    together, the "Parties" and
        each a "Party".

    

    

    INTRODUCTION

    

    

    
      
        	(A)	
                Reference is made to the shareholders' agreement dated 15 June 2012 between the Parties (the "Agreement").

              

      

    

    

    

    
      
        	(B)	
                The Parties, together having the requisite authority under clause 21.1 of the Agreement, wish to amend the Agreement on the terms of this amendment agreement.

              

      

    

    

    

    OPERATIVE PROVISIONS

    

    

    
      
        	1.	
                INTERPRETATION

              

      

    

    

    

    Words and expressions used in this amendment agreement shall have the same meaning as is given to them in the Agreement unless otherwise
        set out in this amendment agreement or if the context otherwise expressly requires.

    

    

    
      
        	2.	
                AMENDMENTS TO THE AGREEMENT

              

      

    

    

    

    
      
        	2.1	
                The Parties agree that clause 1.2.26 of the Agreement shall be deleted and replaced with the following new clause 1.2.26: "Tronox KZN Sands" - Tronox KZN Sands Limited (registration number 1987/001627/07), a private company with limited liability duly incorporated in the Republic of South Africa.

              

      

    

    

    

    
      1

      
        

    

    

    

    
      
        	2.2	
                The Parties agree that clause 1.2.27 of the Agreement shall be deleted and replaced with the following new clause 1.2.27: "Tronox Mineral Sands" - Tronox Mineral Sands Limited (registration number 1998/001039/07), a private company with limited liability duly incorporated in the Republic of South Africa.

              

      

    

    

    

    
      
        	2.3	
                The Parties agree that each reference to "Exxaro Sands" and "Exxaro TSA Sands" throughout the Agreement shall be deleted and replaced with "Tronox KZN Sands" and "Tronox Mineral Sands", respectively.

              

      

    

    

    

    
      
        	2.4	
                The Parties agree that clause 1.2.40 of the Agreement shall be deleted and replaced with the following new clause 1.2.40: "Ownership Requirements" - means the requirements from time to time of the 2018 Charter in respect of the ownership participation by Historically Disadvantaged Persons (as defined in the 2018 Charter) in a mining right holder which,
                      when satisfied, have the consequence that the shareholding by such Historically Disadvantaged Persons is sufficient to enable the maintenance of Existing Mining Rights (as referred to in the 2018 Charter) and to comply with all
                      ownership requirements contained in such Existing Mining Rights.

              

      

    

    

    

    
      
        	2.5	
                The Parties agree that a new clause 1.2.54 shall be introduced with the following text: "2018 Charter" – the Broad-Based Black Socio-Economic Empowerment Charter for the South African Mining and Minerals
                      Industry, 2018.

              

      

    

    

    

    
      
        	2.6	
                The Parties agree that a new clause 1.2.55 shall be introduced with the following text: "Completion Agreement" - means the Exxaro Mineral
                      Sands Transaction Completion Agreement, between Tronox, Tronox LLC, Tronox UK Holdings Limited, Tronox Holdings Plc, Tronox Global Holdings Pty Limited and Exxaro dated as of 26 November 2018.

              

      

    

    

    

    
      
        	2.7	
                The Parties agree that clause 12.3 of the Agreement shall be deleted and replaced with the following new clause 12.3:

              

      

    

    

    

    Either -

    

    

    12.3.1          that Offer
        in terms of 11.1 is not accepted in full; or

    

    

    12.3.2          that Offer
        is accepted in full but the suspensive conditions thereto are not fulfilled,

    

    

    then, within five Business Days thereafter, (i) Exxaro may exercise its "Put Option" (as defined in the Completion
        Agreement) with respect to the relevant Shares and Australia Holdco (or Tronox, as the case may be) may exercise its "Call Option" (as defined in the in the Completion Agreement) with respect to the relevant Shares, under and in accordance with the
        provisions of the Completion Agreement, and (ii) if Exxaro has not exercised its "Put Option" and Australia HoldCo (or Tronox, as the case may be) has not exercised its "Call Option" during such five Business Day period, then, following the expiry
        of that period, Australia HoldCo shall have the right to accept that Proposal, whereupon the other Shareholders shall be obliged to accept and be deemed to have accepted that Proposal. Australia HoldCo and the other Shareholders shall thereafter
        give effect to the sale and cession arising from acceptance of that Proposal.

    

    

    
      2

      
        

    

    

    

    
      
        	2.8	
                The Parties agree that clause 13.1 of the Agreement shall be deleted and replaced with the following new clause 13.1:

              

      

    

    

    

    If Australia HoldCo makes an Offer of its relevant Subject Interest in terms of 11.1, and if Exxaro -

    

    

    13.1.1          does not
        accept that Offer in whole in terms of 11.1; or

    

    

    13.1.2          does
        accept that Offer in whole in terms of 11.1 but the suspensive conditions thereto are then not fulfilled,

    

    

    then Exxaro may within five Business Days thereafter (i) exercise its "Put Option" (as defined in the Completion
        Agreement) with respect to the relevant Shares under and in accordance with the provisions of the Completion Agreement, or (ii) give written notice to the Offeror/s within the Tag Along Period stating that Exxaro exercises its right in terms of
        this 13 ("Tag Along Right").

    

    

    
      
        	2.9	
                The Parties agree that clause 15.4.2 of the Agreement shall be deleted and replaced with the following new clause 15.4.2: as a result of the performance by such Company and its Subsidiaries under any of the elements of the Charter, the MPRDA, and the mining and prospecting rights other than ownership, the DMR agrees, in
                      writing, that HDPs and HDSAs need to hold less than 26% of the Shares in order for the Company and its Subsidiaries to comply with the Ownership Requirement, Exxaro may exercise its "Put Option" (as that phrase is defined in the
                      Completion Agreement) with respect to the relevant Shares and Australia HoldCo (or Tronox, as the case may be) may exercise its "Call Option" (as that phrase is defined in the Completion Agreement) with respect to the relevant Shares,
                      under and in accordance with the provisions of the Completion Agreement in respect of that number of such Shares that Exxaro then holds that is in excess of the lower requirement.

              

      

    

    

    

    
      
        	3.	
                MISCELLANEOUS

              

      

    

    

    

    
      
        	3.1	
                The Parties agree that, from the date of this amendment agreement, any reference to the Agreement shall be construed as a reference to the Agreement as amended by this
                    amendment agreement.

              

      

    

    

    

    
      
        	3.2	
                This amendment agreement may be executed (either by autographic signature or by the Parties applying their signature by some mechanical or other means) in any number of
                    counterparts, each of which shall constitute an original, and all the counterparts shall together constitute one and the same agreement. The exchange of a fully executed (either by autographic signature or by the Parties applying their
                    signature by some mechanical or other means) version of this amendment agreement (in counterparts or otherwise) by electronic transmission or otherwise shall be sufficient to bind the Parties to the terms and conditions of this
                    amendment agreement and no exchange of originals is necessary.

              

      

    

    

    

    
      
        	4.	
                GOVERNING LAW

              

      

    

    

    

    This amendment agreement shall be governed by and construed in accordance with the laws of the Republic of South Africa.

    

    

    (Signature pages follow)

    

    

    
      3

      
        

    

    

    

    IN WITNESS WHEREOF, the parties hereto have caused this agreement to
        be duly executed, all as of the day and year first above written.

    

    

    	
            EXECUTED by TRONOX SANDS HOLDINGS PTY LIMITED:

          	
             

             

            /s/ Jeffrey Neuman

          
	
            Signature of director

          
	
             

             

            /s/ Jeffrey Neuman

          
	 	
            Name

             

             

          
	 
	 

    

    

    [Signature page to the Amendment No 1 to the SA Shareholders Deed]

    

    
      
        

    

    

    

    	
            EXECUTED by TRONOX LIMITED:

          	
             

             

            /s/ Jeffry N. Quinn

          
	
            Signature of director

          
	
            /s/ Jeffry N. Quinn

          
	 	
            Name

             

             

          
	 
	 
	 	 

    

    

    [Signature page to the Amendment No 1 to the SA Shareholders Deed] 

    
      
        

    

    

    

    	
            EXECUTED by TRONOX MINERAL SANDS PROPRIETARY LIMITED:

             

             

          	
             

             

            /s/ Jeffry N. Quinn

          
	
            Signature of director

          
	
            /s/ Jeffry N. Quinn

          
	 	
            Name

             

             

          
	 
	 
	 	 

     

    

     [Signature page to the Amendment No 1 to the SA Shareholders Deed]

    
      
        

    

    	
            EXECUTED by TRONOX KZN SANDS PROPRIETARY LIMITED:

             

             

          	
             

             

            /s/ Jeffry N. Quinn

          
	
            Signature of director

          
	
            /s/ Jeffry N. Quinn

          
	 	
            Name

             

             

          
	 
	 

    

    

    [Signature page to the Amendment No 1 to the SA Shareholders Deed] 

    
      
        

    

    

    

    	
            EXECUTED by EXXARO RESOURCES LIMITED:

          	
             

             

            /s/ P.A. Koppeschaar

          
	
            Signature of director

          
	
            /s/ P.A. Koppeschaar

          
	 	
            Name

             

             

          
	 
	 

    

    

    [Signature page to the Amendment No 1 to the SA Shareholders Deed]

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00292-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00292-of-00352.parquet"}]]