Document:

EX-4.3

  Exhibit 4.3

  DESCRIPTION OF THE REGISTRANT’S SECURITIES

  REGISTERED PURSUANT TO SECTION 12 OF THE

  SECURITIES EXCHANGE ACT OF 1934

  The descriptions below of Vor Biopharma Inc.’s (“we,” “our” or “we”) common stock and provisions of our amended and restated certificate of incorporation (“Restated Certificate”) and amended and restated bylaws (“Bylaws”) are summaries and are qualified by reference to our Restated Certificate and the Bylaws, which are filed as exhibits to this Annual Report on Form 10-K, and by the applicable provisions of the Delaware General Corporation Law (the “DGCL”).

   

  General

  Our authorized capital stock consists of 400,000,000 shares of common stock, $0.0001 par value per share, and 10,000,000 shares of preferred stock, $0.0001 par value per share, all of which shares of preferred stock will be undesignated. Our board of directors may establish the rights and preferences of the preferred stock from time to time.

  Common Stock

  Voting Rights

  Each holder of our common stock is entitled to one vote for each share on all matters submitted to a vote of the stockholders, including the election of directors. The affirmative vote of holders of at least 662/3% of the voting power of all of the then-outstanding shares of capital stock, voting as a single class, will be required to amend certain provisions of our Restated Certificate, including provisions relating to amending our Bylaws, the classified board, the size of our board, removal of directors, director liability, vacancies on our board, special meetings, stockholder notices, actions by written consent and exclusive forum.

  Dividends

  Subject to preferences that may be applicable to any then-outstanding preferred stock, holders of common stock are entitled to receive ratably those dividends, if any, as may be declared from time to time by our board of directors out of legally available funds.

  Liquidation

  In the event of our liquidation, dissolution or winding up, holders of common stock will be entitled to share ratably in the net assets legally available for distribution to stockholders after the payment of all of our debts and other liabilities and the satisfaction of any liquidation preference granted to the holders of any then-outstanding shares of preferred stock.

  Rights, Preferences and Privileges

  Holders of common stock have no preemptive, conversion or subscription rights and there are no redemption or sinking fund provisions applicable to the common stock. The rights, preferences and privileges of the holders of common stock are subject to, and may be adversely affected by, the right of the holders of shares of any series of preferred stock that we may designate in the future.

  Preferred Stock

  Our board of directors have the authority under our Restated Certificate, without further action by our stockholders, 

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  to issue up to 10,000,000 shares of preferred stock in one or more series, to establish from time to time the number of shares to be included in each such series, to fix the rights, preferences and privileges of the shares of each wholly unissued series and any qualifications, limitations or restrictions thereon, and to increase or decrease the number of shares of any such series, but not below the number of shares of such series then outstanding.

  Our board of directors may authorize the issuance of preferred stock with voting or conversion rights that could adversely affect the voting power or other rights of the holders of our common stock. The purpose of authorizing our board of directors to issue preferred stock and determine its rights and preferences is to eliminate delays associated with a stockholder vote on specific issuances. The issuance of preferred stock, while providing flexibility in connection with possible acquisitions and other corporate purposes, could, among other things, have the effect of delaying, deferring or preventing a change in control of us and may adversely affect the market price of our common stock and the voting and other rights of the holders of our common stock. It is not possible to state the actual effect of the issuance of any shares of preferred stock on the rights of holders of common stock until the board of directors determines the specific rights attached to that preferred stock.

  Registration Rights

  We and the holders of our existing preferred stock have entered into an amended and restated investors’ rights agreement. The registration rights provisions of this agreement provide those holders with demand, piggyback and Form S-3 registration rights with respect to the shares of common stock currently held by them and issuable to them upon conversion of our preferred stock in connection with our initial public offering. An aggregate of 17,489,764 shares of common stock are entitled to these registration rights. These shares are collectively referred to herein as registrable securities.

  Demand Registration Rights

  The holders of a majority of registrable securities then outstanding have the right to demand that we file a registration statement covering at least 40% of the registrable securities then outstanding (or a lesser percent if the aggregate offering price exceeds $15.0 million net of certain selling expenses). We are obligated to effect at most two registrations in response to these demand registration rights. These demand registration rights are subject to specified conditions and limitations, including the right of the underwriters, if any, to limit the number of shares included in any such registration under specified circumstances. Upon such a request, we are required to effect the registration as soon as practicable, but in any event no later than 60 days after the receipt of such request.

  Piggyback Registration Rights

  If we propose to register any of our securities under the Securities Act of 1933, as amended (the “Securities Act”) either for our own account or for the account of other stockholders, the holders of registrable securities will each be entitled to notice of the registration and will be entitled to include their shares of common stock in the registration statement. These piggyback registration rights are subject to specified conditions and limitations, including the right of the underwriters to limit the number of shares included in any such registration under specified circumstances, and do not apply to a registration relating to any equity incentive plan, stock purchase or similar plan, a transaction under Rule 145 of the Securities Act, a registration on any form that does not include substantially the same information as would be required to be included in a registration statement covering the sale of the registrable securities or a registration related to common stock issued upon conversion of debt securities.

  Registration on Form S-3

  At any time after we become eligible to file a registration statement on Form S-3, the holders of at least 15% of the registrable securities then outstanding will be entitled to request to have such shares registered by us on a Form S-3 registration statement. These Form S-3 registration rights are subject to other specified conditions and limitations, including the condition that the anticipated aggregate offering price, net of certain selling expenses, is at least $5.0 million. Upon receipt of this request, the holders of registrable securities will each be entitled to participate in this 

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  registration. We will not be required to effect such a registration if, within any twelve month period, we have already effected two registrations on Form S-3 for the holders of registrable securities.

  Expenses of Registration

  We are required to pay all expenses, including fees and expenses of one counsel to represent the selling stockholders, relating to any demand, piggyback or Form S-3 registration, other than underwriting discounts and commissions, stock transfer taxes and any additional fees of counsel for the selling stockholders, subject to specified conditions and limitations. We are not required to pay registration expenses if a demand registration request is withdrawn at the request of a majority of holders of registrable securities to be registered, unless holders of a majority of the registrable securities agree to forfeit their right to one demand registration.

  The amended and restated investors’ rights agreement contains customary cross-indemnification provisions, pursuant to which we are obligated to indemnify the selling stockholders in the event of material misstatements or omissions in the applicable registration statement attributable to us, and the selling stockholders are obligated to indemnify us for material misstatements or omissions in the registration statement attributable to them, subject to certain limitations.

  Termination of Registration Rights

  The registration rights granted under the investors’ rights agreement will terminate with respect to any particular stockholder upon the earlier of (i) the closing of a deemed liquidation event, as defined in our Restated Certificate ; (ii) with respect to each stockholder, at such time such stockholder is able to sell all of its shares pursuant to Rule 144 or another similar exemption under the Securities Act during a three-month period without registration; and (iii) the fifth anniversary of February 5, 2021.

  Anti-Takeover Provisions

  Section 203 of the DGCL

  We are subject to Section 203 of the DGCL, which prohibits a Delaware corporation from engaging in any business combination with any interested stockholder for a period of three years after the date that such stockholder became an interested stockholder, with the following exceptions:

  •before such date, the board of directors of the corporation approved either the business combination or the transaction that resulted in the stockholder becoming an interested stockholder;

  •upon completion of the transaction that resulted in the stockholder becoming an interested stockholder, the interested stockholder owned at least 85% of the voting stock of the corporation outstanding at the time the transaction began, excluding for purposes of determining the voting stock outstanding, but not the outstanding voting stock owned by the interested stockholder, those shares owned (i) by persons who are directors and also officers and (ii) employee stock plans in which employee participants do not have the right to determine confidentially whether shares held subject to the plan will be tendered in a tender or exchange offer; or

  •on or after such date, the business combination is approved by the board of directors and authorized at an annual or special meeting of the stockholders, and not by written consent, by the affirmative vote of at least 662/3% of the outstanding voting stock that is not owned by the interested stockholder.

  In general, Section 203 defines a “business combination” to include the following:

  •any merger or consolidation involving the corporation or any direct or indirect majority-owned subsidiary of the corporation and the interested stockholder;

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  •any sale, transfer, pledge or other disposition of 10% or more of the assets of the corporation involving the interested stockholder (in one transaction or a series of transactions);

  •subject to certain exceptions, any transaction that results in the issuance or transfer by the corporation or by any direct or indirect majority-owned subsidiary of the corporation of any stock of the corporation or of such subsidiary to the interested stockholder;

  •any transaction involving the corporation or any direct or indirect majority-owned subsidiary of the corporation that has the effect of increasing the proportionate share of the stock or any class or series of the corporation beneficially owned by the interested stockholder; or

  •the receipt by the interested stockholder of the benefit of any loans, advances, guarantees, pledges or other financial benefits by or through the corporation.

  In general, Section 203 defines an “interested stockholder” as an entity or person who, together with the person’s affiliates and associates, beneficially owns, or within three years prior to the time of determination of interested stockholder status did own, 15% or more of the outstanding voting stock of the corporation.

  Restated Certificate and Amended and Restated Bylaws

  Our Restated Certificate provides for our board of directors to be divided into three classes with staggered three-year terms. Only one class of directors will be elected at each annual meeting of our stockholders, with the other classes continuing for the remainder of their respective three-year terms. Because our stockholders do not have cumulative voting rights, stockholders holding a majority of the shares of common stock outstanding will be able to elect all of our directors. Our Restated Certificate and our Bylaws also provide that directors may be removed by the stockholders only for cause upon the vote of 662/3% or more of our outstanding common stock. Furthermore, the authorized number of directors may be changed only by resolution approved by a majority of the board of directors, and vacancies and newly created directorships on the board of directors may, except as otherwise required by law or determined by the board, only be filled by a majority vote of the directors then serving on the board, even though less than a quorum.

  Under our Restated Certificate and Bylaws our stockholders do not have cumulative voting rights. Because of this, the holders of a majority of the shares of common stock entitled to vote in any election of directors can elect all of the directors standing for election, if they should so choose.

  Our Restated Certificate and Bylaws also provide that all stockholder actions must be effected at a duly called meeting of stockholders and will eliminate the right of stockholders to act by written consent without a meeting. Our Bylaws also provide that only the chair of our board, Chief Executive Officer or the board of directors pursuant to a resolution adopted by a majority of the total number of authorized directors may call a special meeting of stockholders.

  Our Bylaws provides that stockholders seeking to present proposals before a meeting of stockholders to nominate candidates for election as directors at a meeting of stockholders must provide timely advance notice in writing, and will specify requirements as to the form and content of a stockholder’s notice.

  Our Restated Certificate and Bylaws provide that the stockholders cannot amend many of the provisions described above except by a vote of 662∕3% or more of our outstanding common stock.

  As described in “—Preferred Stock” above, our Restated Certificate gives our board of directors the authority, without further action by our stockholders, to issue up to 10,000,000 shares of preferred stock in one or more series, with any rights, preferences and privileges as they may designate, including the right to approve an acquisition or other change in control.

  The combination of these provisions will make it more difficult for our existing stockholders to replace our board of 

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  directors as well as for another party to obtain control of us by replacing our board of directors. Since our board of directors has the power to retain and discharge our officers, these provisions could also make it more difficult for existing stockholders or another party to effect a change in management. In addition, the authorization of undesignated preferred stock makes it possible for our board of directors to issue preferred stock with voting or other rights or preferences that could impede the success of any attempt to change our control.

  These provisions are intended to enhance the likelihood of continued stability in the composition of our board of directors and its policies and to discourage coercive takeover practices and inadequate takeover bids. These provisions are also designed to reduce our vulnerability to hostile takeovers and to discourage certain tactics that may be used in proxy fights. However, such provisions could have the effect of discouraging others from making tender offers for our shares and may have the effect of delaying changes in our control or management. As a consequence, these provisions may also inhibit fluctuations in the market price of our stock that could result from actual or rumored takeover attempts. We believe that the benefits of these provisions, including increased protection of our potential ability to negotiate with the proponent of an unfriendly or unsolicited proposal to acquire or restructure our company, outweigh the disadvantages of discouraging takeover proposals, because negotiation of takeover proposals could result in an improvement of their terms.

  Choice of Forum

  Our Restated Certificate provides that the Court of Chancery of the state of Delaware will be the exclusive forum for the following types of actions or proceedings under Delaware statutory or common law:

  •any derivative action or proceeding brought on our behalf;

  •any action asserting a breach of fiduciary duty;

  •any action asserting a claim against us arising pursuant to the DGCL, our Restated Certificate, or our Bylaws; or

  •any action asserting a claim against us that is governed by the internal affairs doctrine.

  The provision would not apply to suits brought to enforce a duty or liability created by the Securities Exchange Act of 1934, as amended. Furthermore, Section 22 of the Securities Act creates concurrent jurisdiction for federal and state courts over all such Securities Act actions. Accordingly, both state and federal courts have jurisdiction to entertain such claims. To prevent having to litigate claims in multiple jurisdictions and the threat of inconsistent or contrary rulings by different courts, among other considerations, our Restated Certificate also provide that unless we consent in writing to the selection of an alternative forum, the federal district courts of the United States shall be the exclusive forum for the resolution of any complaint asserting a cause of action arising under the Securities Act.

  While the Delaware courts have determined that such choice of forum provisions are facially valid, a stockholder may nevertheless seek to bring a claim in a venue other than those designated in the exclusive forum provisions. In such instance, we would expect to vigorously assert the validity and enforceability of the exclusive forum provisions of our Restated Certificate. This may require significant additional costs associated with resolving such action in other jurisdictions and there can be no assurance that the provisions will be enforced by a court in those other jurisdictions

  These exclusive forum provisions may limit a stockholder’s ability to bring a claim in a judicial forum that it finds favorable for disputes with us or our directors, officers, or other employees, which may discourage lawsuits against us and our directors, officers and other employees. If a court were to find either exclusive-forum provision in our Restated Certificate to be inapplicable or unenforceable in an action, we may incur further significant additional costs associated with resolving the dispute in other jurisdictions, all of which could seriously harm our business.

  Our Restated Certificate further provides that the federal district courts of the United States of America will be the 

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  exclusive forum for resolving any complaint asserting a cause of action arising under the Securities Act, subject to and contingent upon a final adjudication in the State of Delaware of the enforceability of such exclusive forum provision.

  Transfer Agent and Registrar

  The transfer agent and registrar for our common stock is Computershare Trust Company, N.A. The transfer agent’s address is 150 Royall Street, Canton, Massachusetts 02021.

  Listing

  Our common stock is listed on the Nasdaq Global Select Market under the trading symbol “VOR”.

   

  6EX-10.132

  Exhibit 10.13.2

  THIRD AMENDMENT TO OFFICE LEASE

  This Third Amendment to Office Lease (this “Third Amendment”) is dated as of January 24, 2022, by and between Aero-Tech Investments, LLC, a Colorado limited liability company (“Landlord”), and Biodesix, Inc., a Delaware corporation (“Tenant”).

   

  Recitals

   

  A.Landlord and Tenant entered into that certain Office Lease dated as of October 5, 2011, as amended by that certain First Amendment to Office Lease dated as of May 31, 2016 (the “First Amendment”), that certain Second Amendment to Office Lease dated as of August 29, 2017, and the Letter Agreement dated June 30, 2021 (collectively, the “Lease”) pursuant to which Tenant leased certain space as further described in the Lease of the building having a street address of 2970 Wilderness Place, Colorado 80301 (the “Building”) and containing approximately 34,595 rentable square feet of space.

   

  B.The Term of the Lease is scheduled to expire on January 14, 2023, and Tenant desires to extend the Term for an additional twelve (12) months with the option to accelerate Expiration Date at any time on not less than ninety (90) days’ notice to Landlord.

   

  C.Landlord and Tenant desire to amend the Lease on the terms and conditions set forth in this Third Amendment.

   

  Amendment

   

  NOW, THEREFORE, in consideration of the foregoing and the promises and conditions of this Third Amendment, the parties agree as follows:

   

  1.Capitalized Terms. All capitalized terms not otherwise defined in this Third Amendment shall have the same meanings as defined in the Lease.

   

  2.Extension of Term. The Term is hereby extended such that the Expiration Date, as set forth in the Summary of Basic Lease Information comprising a portion of the Lease, is hereby amended, and restated to be January 14, 2024. The period from January 15, 2023, through and including January 14, 2024, is referred to herein as the “Extended Term”.

   

  3.Additional Amendments to Lease:

   

  3.1During the Extended Term, the Annual Base Rent shall be $28.00/Square Foot/Year.

  3.2In the event Tenant subleases the Premises or any portion thereof prior to the expiration of the Lease, Landlord will receive 100% of any net profits above the Rent payable by Tenant under the Lease.

  3.3Addendum One to the Lease (which was previously amended and restated in its entirely pursuant to the First Amendment) is hereby deleted in its entirety and is of no further force or effect.

  3.4Tenant shall have the right (the “Early Termination Option”) to accelerate the Expiration Date with respect to the entire Premises only, from the scheduled Expiration Date to the last day of any calendar month during the Term, as extended by this Amendment, on not less than ninety (90) days’ prior written notice to Landlord. If Tenant validly exercises the Early Termination Option, then (i) notwithstanding any contrary provision of the Lease, but subject 

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  to the terms of this section, the Term of the Lease shall expire, with respect to the entire Premises, on such accelerated Expiration Date with the same force and effect as if such term were, by the provisions of the Lease, fixed to expire on such accelerated Expiration Date; and (ii) without limiting the foregoing, (A) Tenant shall surrender the Premises to Landlord in accordance with the terms of the Lease on or before such accelerated Expiration Date, (B) Tenant shall remain liable for all Rent and other amounts payable under the Lease for the period up to and to and including such accelerated Expiration Date, even though billings for such amounts may occur after such accelerated Expiration Date, (C) Tenant’s restoration obligations in respect of the Premises shall be as set forth in the Lease, (D) if Tenant fails to surrender all or any portion of the Premises on or before such accelerated Expiration Date, Tenant’s tenancy shall be subject to Article 23 (Holdover) of the Lease, and (E) any other rights or obligations of Landlord or Tenant under the Lease which, in the absence of the early termination of the Term, would have survived the scheduled Expiration Date shall survive such accelerated Expiration Date. Notwithstanding any contrary provision of the Lease, from and after the date Tenant duly exercises the Early Termination Option, Tenant shall not assign the Lease or sublease all or any portion of the Premises for any period following such accelerated Expiration Date.

   

  4.Counterparts; Facsimile, PDF. This Third Amendment may be executed in any number of identical counterparts, all of which, when taken together, shall constitute the same instrument. A facsimile or .pdf copy of this Third Amendment shall be deemed an original for all relevant purposes. Time is of the essence with respect to all rights and obligations of the parties under this Third Amendment.

   

  5.Ratification. Except as modified by this Third Amendment, the Lease shall remain otherwise unmodified and in full force and effect and the parties ratify and confirm the terms of the Lease as modified by this Third Amendment. The Lease (as amended hereby) contains the entire agreement between Landlord and Tenant as to the Premises, and there are no other agreements, oral or written, between Landlord and Tenant relating to the Premises.

   

  6.Conflict. Except as modified hereby, the Lease shall be and remain in full force and effect. In the event of any conflict between the terms of the Lease and the terms of this Third Amendment, the terms of this Third Amendment shall control.

   

  7.Broker. Tenant covenants, warrants and represents to Landlord that no broker or other similar agent represented Tenant in the negotiation of this Amendment other than Cushman & Wakefield (Steve Billigmeier and Rob Bain) (“Tenant’s Broker”). Landlord covenants, warrants and represents to Tenant that no broker or other similar agent represented Landlord in the negotiation of this Amendment. Each party agrees to and hereby does defend, indemnify and hold the other harmless against and from any brokerage commissions or finder’s fees or claims therefore by a party other than Tenant’s Broker claiming to have dealt with the indemnifying party and all costs, expenses and liabilities in connection therewith, including, without limitation, reasonable attorneys’ fees and expenses, for any breach of the foregoing. The foregoing indemnification shall survive the termination or earlier expiration of the Lease.

   

   

   

  [Signatures on Following Page]

   

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  IN WITNESS WHEREOF, Landlord and Tenant have executed this Third Amendment as of the day and year first above written.

   

  LANDLORD:	AERO-TECH INVESTMENTS, LLC, a Colorado limited liability company

   

   

  By:  /s/ AARON CLAMAN	 

                   Aaron Claman, its Manager

   

   

  TENANT:	BIODESIX, INC. a Delaware corporation

   

   

  By:  /s/ ROBIN HARPER COWIE 

                   Robin Harper Cowie, its CFO

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