Document:

Exhibit 10.3

 

CONFIDENTIAL TREATMENT REQUESTED UNDER

C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406.

[****] INDICATES OMITTED MATERIAL THAT IS THE

SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST

FILED SEPARATELY WITH THE COMMISSION.

THE OMITTED MATERIAL HAS BEEN FILED

	SEPARATELY WITH THE COMMISSION.	 	EXECUTION COPY

 

FIRST
AMENDMENT TO LICENSE AGREEMENT

 

THIS FIRST AMENDMENT
(this “AMENDMENT”), made as of September 1, 2010 amends the certain License Agreement, effective as of April
1, 2010 (the “AGREEMENT”), entered into by and between the Board of Trustees of the University of Arkansas acting
for and on behalf of the University of Arkansas for Medical Sciences, a public institution of higher education having principal
offices at 2404 North University Avenue, Little Rock, Arkansas 72207, United States of America (hereinafter “UNIVERSITY”),
and Myeloma Health LLC, a Delaware limited liability company having a principal office at 667 Madison Avenue, 14th Floor,
New York, New York 10065 (hereinafter “LICENSEE”), and shall be effective as of the EFFECTIVE DATE (as such
term is defined in the AGREEMENT).

 

WITNESSETH

 

WHEREAS, UNIVERSITY
and LICENSEE wish to amend the AGREEMENT to recognize that the following patent applications, identified by UNIVERSITY disclosure
numbers: [****]and [****] (the “[****] FILINGS”), [****] (the “[****] FILINGS”), [****] (the
“[****] FILINGS”), [****] (the “[****] FILINGS”), [****] (the “[****] FILINGS”)
and [****] (the “[****]FILINGS”) are within the scope of the PATENT RIGHTS (as such term is defined in the AGREEMENT)
under Section 2.12(a).

 

NOW, THEREFORE, UNIVERSITY
and LICENSEE hereby amend the AGREEMENT as follows:

 

		1.	UNIVERSITY and LICENSEE acknowledge and agree that the [****] FILINGS[****] FILINGS, [****] FILINGS,
[****] FILINGS and [****] FILINGS are within the scope of the PATENT RIGHTS under Section 2.12(a). As a consequence, Appendix A
shall be revised to include the following new table entries:

 

	“[****]”
	UAMS Disclosure #	Applications	Publications	U.S. Patents	Overseas Publication	Overseas Patents
	[****]	[****]	 	[****]	 	 
	[****]	[****]	 	[****]	 	 

 

    	 

    	 

    

 

CONFIDENTIAL TREATMENT REQUESTED UNDER

C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406.

[****] INDICATES OMITTED MATERIAL THAT IS THE

SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST

FILED SEPARATELY WITH THE COMMISSION.

THE OMITTED MATERIAL HAS BEEN FILED

	SEPARATELY WITH THE COMMISSION.	 	 

 

	“[****]”
	UAMS Disclosure #	Applications	Publications	U.S. Patents	Overseas Publication	Overseas Patents
	[****]	[****]	 	[****]	 	 

 

	“[****]”
	UAMS Disclosure #	Applications	Publications	U.S. Patents	Overseas Publication	Overseas Patents
	[****]	[****]	 	[****]	 	 

 

	“[****]”
	UAMS Disclosure #	Applications	Publications	U.S. Patents	Overseas Publication	Overseas Patents
	[****]	[****]	 	 	 	 

 

	“[****]”
	UAMS Disclosure #	Applications	Publications	U.S. Patents	Overseas Publication	Overseas Patents
	[****]	[****]	 	[****]	 	 

 

	“[****]”
	UAMS Disclosure #	Applications	Publications	U.S. Patents	Overseas Publication	Overseas Patents
	[****]	[****]	 	 	 	 

 

		2.	Appendix B shall be revised to include the following new table entry under the heading “The
following patent applications are included in PATENT RIGHTS and apply to both fluorescence in situ hybridization
(FISH) testing and the LICENSED FIELD:”

 

	UAMS Disclosure #	Applications
	[****]	[****]

 

    	 

    	 

    

 

CONFIDENTIAL TREATMENT REQUESTED UNDER

C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406.

[****] INDICATES OMITTED MATERIAL THAT IS THE

SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST

FILED SEPARATELY WITH THE COMMISSION.

THE OMITTED MATERIAL HAS BEEN FILED

	SEPARATELY WITH THE COMMISSION.	 	 

 

		3.	UNIVERSITY and LICENSEE acknowledge and agree that the patent costs incurred by UNIVERSITY and
paid to third parties in connection with the preparation, filing, prosecution and maintenance, as of invoices received:

 

		a.	as of the EFFECTIVE DATE are as follows:

 

		(i)	[****] FILINGS: $[****],

 

		(ii)	[****] FILINGS: $[****],

 

		(iii)	[****] FILINGS: $[****],

 

		(iv)	[****] FILINGS: $[****],

 

		(v)	[****] FILINGS: $[****], and

 

		(vi)	[****] FILINGS: $[****]

 

		b.	after the EFFECTIVE DATE are as follows:

 

		(i)	[****] FILINGS:,

		(ii)	[****] FILINGS:,

		(iii)	[****] FILINGS:,

		(iv)	[****] FILINGS:,

		(v)	[****] FILINGS:, and

		(vi)	[****] FILINGS:.

 

The amount
of such patent costs that LICENSEE shall reimburse to UNIVERSITY shall be determined in accordance with Section 5.1(e) (i) (the
“[****],[****],[****],[****],[****],[****]and [****] PATENT COSTS”).

 

		4.	UNIVERSITY shall amend the separate letter signed by an authorized representative of UNIVERSITY
pursuant to Section 5.1(e) (ii) to include the [****],[****],[****],[****],[****],[****] and [****] PATENT COSTS incurred by UNIVERSITY
prior to the EFFECTIVE DATE.

 

    	 

    	 

    

 

CONFIDENTIAL TREATMENT REQUESTED UNDER

C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406.

[****] INDICATES OMITTED MATERIAL THAT IS THE

SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST

FILED SEPARATELY WITH THE COMMISSION.

THE OMITTED MATERIAL HAS BEEN FILED

	SEPARATELY WITH THE COMMISSION.	 	 

 

		5.	LICENSEE shall pay to UNIVERSITY:

 

		a.	the patent costs for the [****],[****],[****],[****],[****],[****] and [****] PATENT COSTS incurred
by UNIVERSITY prior to the EFFECTIVE DATE in accordance with Section 5.1(e)(ii).

 

		b.	the patent costs for the [****],[****],[****],[****],[****],[****]and [****] PATENT COSTS incurred
by UNIVERSITY after the EFFECTIVE DATE in accordance with Section 5.1(e)(iii)

 

		6.	Except as provided herein above, all other terms and conditions of the AGREEMENT remain the same
and in effect.

 

(Signature page follows)

 

    	 

    	 

    

 

CONFIDENTIAL TREATMENT REQUESTED UNDER

C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406.

[****] INDICATES OMITTED MATERIAL THAT IS THE

SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST

FILED SEPARATELY WITH THE COMMISSION.

THE OMITTED MATERIAL HAS BEEN FILED

	SEPARATELY WITH THE COMMISSION.	 	EXECUTION COPY

 

IN WITNESS WHEREOF,
the PARTIES hereto have caused this AMENDMENT to be executed by their duly authorized representatives.

 

	BOARD OF TRUSTEES OF THE	 	MYELOMA HEALTH LLC
	UNIVERSITY OF ARKANSAS	 	 	 
	 	 	 	 	 
	/s/ Ann Kemp	 	/s/ Joe Hernandez
	By:	Ann Kemp	 	By:	Joe Hernandez
	Title:	Vice President for Administration	 	Title:	Chief Executive Officer
	 	 	 	 	 
	Date:	8/26/10	 	Date: 	8/19/10

 

[Signature Page to First Amendment to License
Agreement]Exhibit 10.4

 

CONFIDENTIAL TREATMENT REQUESTED UNDER

C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406.

[****] INDICATES OMITTED MATERIAL THAT IS THE

SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST

FILED SEPARATELY WITH THE COMMISSION.

THE OMITTED MATERIAL HAS BEEN FILED

SEPARATELY WITH THE COMMISSION.

 

AMENDMENT #2 to the LICENSE AGREEMENT

 

THIS AMENDMENT (“Amendment”)
is made by and between the Board of Trustees of the University of Arkansas acting for and on behalf of the University of Arkansas
for Medical Sciences, a public institution of higher education having principal offices at 2404 North University Avenue, Little
Rock, Arkansas 72207, United States of America (hereinafter “University”), and Myeloma Health LLC, a Delaware
limited liability company having a principal office at 667 Madison Avenue, 14th Floor, New York, New York 10065 (hereinafter
“Licensee”).

 

WITTNESSETH

 

WHEREAS, on April 1, 2010, the University
and Licensee entered a license agreement (“Agreement”).

 

WHEREAS, the University and Licensee wish
to amend the Agreement for clarity.

 

Amendments

 

NOW, THEREFORE, the University and Licensee,
in consideration of the premises and the mutual covenants contained herein, hereby agree as follows:

 

		1.	This Amendment is made effective as of September 14, 2010 (“Second Amendment Date”).

 

		2.	Article 2.4 of the Agreement shall be replaced as follows:

 

“HIPAA” shall
have the meaning in Article 10.2.

 

		3.	Article 2.5 of the Agreement shall be replaced as follows:

 

“INVENTION”
means any invention or discovery that is within the subject matter of the PATENT RIGHTS and has application within the LICENSED
FIELD in the TERRITORY whether or not patentable or copyrightable, including but not limited to processes, methods, software, formulae,
techniques, compositions of matter, devices, and improvements thereof and know-how relating thereto, in each case which is conceived
and reduced to practice during the TERM in whole or in part by Bart Barlogic, MD, Ph.D. or John Shaughnessy, Ph.D.

 

		4.	Article 2.13 of the Agreement shall be replaced as follows:

 

“PHI” shall
have the meaning in Article 10.2.

 

    	 

    	 

    

 

CONFIDENTIAL TREATMENT REQUESTED UNDER

C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406.

[****] INDICATES OMITTED MATERIAL THAT IS THE

SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST

FILED SEPARATELY WITH THE COMMISSION.

THE OMITTED MATERIAL HAS BEEN FILED

SEPARATELY WITH THE COMMISSION.

 

		5.	Article 2.15 of the Agreement shall be replaced as follows:

 

“TECHNOLOGY RIGHTS”
shall mean data and information within the subject matter of the PATENT RIGHTS and has application within the LICENSED FIELD in
the TERRORITY with respect to (a) clinical samples obtained in clinical research having application within the LICENSED FIELD (but
excluding clinical samples obtained in clinical research under third party agreements entered into after the Second Amendment Date),
including but not limited to clinical research under University Protocol UARK91-04 and data and information corresponding to the
patients from whom the samples were obtained, including but not limited to, diagnosis and clinical outcome; (b) nucleic acids and/or
derivatives thereof derived from such clinical samples, and data and information derived from analyzing nucleic acids obtained
from such clinical samples including but not limited to genomic data and expression levels of mRNA and/or, by virtue of the conversion
of mRNA to protein, the protein derived from CD-138-enriched plasma cells from patients with multiple myeloma and other plasma
cell dyscrasias, in each case that is in the possession or control of UNIVERSITY; and (c) any trade secret right, bailment right,
or copyright in any of the following: UNIVERSITY technical information, patient data, know-how, processes, procedures, compositions,
devices, method formulae, protocols, techniques, software, designs, drawings or other data relating to the LICENSED FIELD. Notwithstanding
the foregoing, data and information provided under this Agreement shall be provided in a manner consistent with the HIPAA authorizations
and written consent forms, when applicable. For patient data for which no authorization has been obtained, only de-identified data
will be provided. For the sake of clarity, TECHNOLGY RIGHTS to which UNIVERSITY has granted and is granting to LICENSEE an exclusive
license under Article 3.1 of the Agreement includes, without limitation, the historical Multiple Myeloma Gene Expression Database
and the related historical patient outcome data.

 

		6.	Article 5.1(b) of the Agreement is hereby amended to add the following at the end of such Article:

 

UNIVERSITY hereby waives and agrees that LICENSEE is
under no obligation to pay the payment of [****] Dollars ($[****]) by LICENSEE that was due under this Article 5.1(b) on April
1, 2011 anniversary of the EFFECTIVE DATE.

 

		7.	Article 5.1(e)(ii) of the Agreement is hereby deleted, and UNIVERSITY hereby waives and agrees that LICENSEE is under no obligation
to pay any amounts under said Article 5.1(e)(ii).

 

    	 

    	 

    

 

CONFIDENTIAL TREATMENT REQUESTED UNDER

C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406.

[****] INDICATES OMITTED MATERIAL THAT IS THE

SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST

FILED SEPARATELY WITH THE COMMISSION.

THE OMITTED MATERIAL HAS BEEN FILED

SEPARATELY WITH THE COMMISSION.

 

		8.	Article 10.2 of the Agreement shall be replaced as follows:

 

UNIVERSITY represents and warrants
to LICENSEE that UNIVERSITY is the sole owner of the PATENT RIGHTS and TECHNOLOGY RIGHTS and, as of the EFFECTIVE DATE, has the
right and authority to grant the rights and licenses granted to LICENSEE set forth in this AGREEMENT, subject to certain retained
rights of the United States government and certain third party research sponsors as set forth in Schedule 10.2. In addition, and
without limitation on the foregoing, UNIVERSITY represents and warrants that any information contained in the TECHNOLOGY RIGHTS
that is or may be considered protected health information (“PHI”), including, without limitation, information
that would identify human research subjects, has been and will be maintained by UNIVERSITY in compliance with all applicable laws
and regulations, including without limitation, the Health Insurance Portability and Accountability Act of 1996 (“HIPAA”),
as amended, and its implementing regulations, and that UNIVERSITY has (or shall collect and maintain) all authorizations required
under HIPAA and other applicable laws permitting UNIVERSITY to disclose such PHI to LICENSEE as contemplated by this AGREEMENT.
LICENSEE may use or further disclose such PHI to the extent permitted under this AGREEMENT, HIPAA and its implementing regulations,
and other applicable laws.

 

		9.	The Agreement shall be amended to include a new Schedule 10.2, attached hereto as Schedule 10.2.

 

		10.	All other terms and conditions of the Agreement that have not been amended herein shall remain
in full force and effect.

 

		11.	The recitals and preamble set forth prior to the enumerated sections of this Amendment are hereby
incorporated by reference in their entirety and made a part of this Amendment as if fully set forth herein.

 

IN WITNESS WHEREOF, the parties have caused
this Amendment to be executed by their duly authorized representatives.

 

	BOARD OF TRUSTEES OF THE 

UNIVERSITY OF ARKANSAS	 	MYELOMA HEALTH LLC
	 	 	 	 	 
	By:	/s/ Barbara A. Goswick	 	By:	/s/ Joe Hernandez
	 	 	 	 	 
	Name: 	Barbara A. Goswick	 	Name:	Joe Hernandez
	 	 	 	 	 
	Title:	VP for Finance and CFO	 	Title:	President and CEO

 

    	 

    	 

    

 

CONFIDENTIAL TREATMENT REQUESTED UNDER

C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406.

[****] INDICATES OMITTED MATERIAL THAT IS THE

SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST

FILED SEPARATELY WITH THE COMMISSION.

THE OMITTED MATERIAL HAS BEEN FILED

SEPARATELY WITH THE COMMISSION.

 

SCHEDULE 10.2

 

THIRD PARTY RESEARCH SPONSORS

 

		(a)	Investigator-Initiated Clinical Trial Agreement, by and among the Board of Trustees of the University of Arkansas on behalf
of the University of Arkansas for Medical Sciences, Bart Barlogie, MD, PhD, and Millennium Pharmaceuticals, Inc., effective as
of January 26, 2004.

		(b)	Investigator-Initiated Clinical Trial Agreement, by and among the Board of Trustees of the University of Arkansas on behalf
of the University of Arkansas for Medical Sciences, Bart Barlogie, MD, PhD, and Millennium Pharmaceuticals, Inc., with a partial
title of “Data Management and Collection, Database entry, Bioinformatics, Gene Expression Profiling and Statistical Analysis
related to Phase II Study.”

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00228-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00228-of-00352.parquet"}]]