Document:

exv10w16

 

Exhibit 10.16

Avalon Pharmaceuticals, Inc.

Incentive Stock Option Agreement

     1. Grant of Option. Avalon Pharmaceuticals, Inc., a Delaware corporation (the
“Company”) hereby grants to                     , an individual whose address is set forth below the optionee signature line (the “Optionee”), an option, pursuant to the Company’s 1999 Stock Plan (the
“Plan”), to purchase an aggregate of 30,000 shares of common stock of the Company (“Common Stock”)
at a price of $.20 per share, purchasable as set forth in and subject to the terms and conditions
of this option and the Plan. Except where the context otherwise requires, the term “Company” shall
include the parent and all present and future subsidiaries of the Company as defined in Sections
424(e) and 424(f) of the Internal Revenue Code of 1986, as amended or replaced from time to time
(the “Code”).

     2. Incentive Stock Option. This option is intended to qualify as an incentive stock
option (“Incentive Stock Option”) within the meaning of Section 422 of the Code. Any provision of
this Agreement which conflicts with the requirements of qualification as an Incentive Stock
Option under the Code is null and void to the extent of such conflict and any ambiguities shall
be resolved so that this option qualifies as an Incentive Stock Option.

     3. Exercise of Option and Provisions for Termination.

          (a) Vesting Schedule. Except as otherwise provided in this Agreement, this option
may be exercised as to the number of shares indicated opposite the respective dates on Schedule A
hereto (“Vested Shares”). This option may not be exercised with respect to any shares after the
tenth anniversary of the date of grant (hereinafter the “Expiration Date”).

          (b) Exercise Procedure. Subject to the conditions set forth in this Agreement, this
option shall be exercised by the Optionee’s delivery of written notice of exercise to the
Company, specifying the number of shares to be purchased and the purchase price to be paid
therefor and accompanied by payment in full in accordance with Section 4. Such exercise shall be
effective upon receipt by the Company of such written notice together with the required payment.
The Optionee may purchase less than the number of shares covered hereby, provided that no partial
exercise of this option may be for any fractional share or for less than one whole share.

          (c) Continuous Employment Required. Except as otherwise provided in this Section 3,
this option may not be exercised unless the Optionee, at the time he or she exercises this
option, is, and has been at all times since the date of grant of this option, an employee of the
Company. For all purposes of this option, (i) “employment” shall be defined in accordance with
the provisions of Section 1.421-7(h) of the Income Tax Regulations or any successor regulations,
and (ii) if this option shall be assumed or a new option substituted therefor in a transaction to
which Section 424(a) of the Code applies, employment by such assuming or substituting corporation
(hereinafter called the “Successor Corporation”) shall be considered for all purposes of this
option to be employment by the Company.

 

 

          (d) Exercise Period Upon Termination of Employment. If the Optionee ceases to be
employed by the Company for any reason, then, except as provided in paragraphs (e) and (f) below,
the right to exercise this option shall terminate three months after such cessation (but in no
event after the Expiration Date), provided that this option shall be exercisable only to
the extent that the Optionee was entitled to exercise this option on the date of such cessation.
Notwithstanding the foregoing, if the Optionee, prior to the Expiration Date, materially violates
any non-competition or confidentiality provisions of any agreement between the Optionee and the
Company, the right to exercise this option shall terminate immediately upon such violation.

          (e) Exercise Period Upon Death or Disability. If the Optionee dies or becomes
disabled (within the meaning of Section 22(e)(3) of the Code) prior to the Expiration Date while
he or she is an employee of the Company, or if the Optionee dies within three months after the
Optionee ceases to be an employee of the Company (other than as the result of a discharge for
“cause” as specified in paragraph (f) below), this option shall be exercisable, within the period
of one year following the date of death or disability of the Optionee (but in no event after the
Expiration Date), by the Optionee or by the person to whom this option is transferred by will or
the laws of descent and distribution; provided that this option shall be exercisable only
to the extent that this option was exercisable by the Optionee on the date of his or her death or
disability. Except as otherwise indicated by the context, the term “Optionee”, as used in this
option, shall be deemed to include the estate of the Optionee or any person who acquires the
right to exercise this option by bequest or inheritance or otherwise by reason of the death of the
Optionee.

          (f) Voluntary Termination or Discharge for Cause. If the Optionee, prior to the
Expiration Date, ceases his or her employment with the Company because he or she voluntarily
resigns or is discharged for “Cause” (as defined below), the right to exercise this option shall
terminate immediately upon such cessation of employment. “Cause” is conduct, as determined by the
Board of Directors, involving one or more of the following: (i) gross misconduct by the Optionee
which is materially injurious to the Company; or (ii) the commission of an act of embezzlement,
fraud or deliberate disregard of the rules or policies of the Company which results in material
economic loss, damage or injury to the Company; or (iii) the unauthorized disclosure of any trade
secret or confidential information of the Company or any third party who has a business
relationship with the Company or the violation of any noncompetition covenant or assignment of
inventions obligation with the Company; or (iv) the commission of any act which induces any
customer or prospective customer of the Company to break a contract with the Company or to
decline to do business with the Company; or (v) the conviction of the Optionee of a felony
involving any financial impropriety or which would materially interfere with the Optionee’s
ability to perform his or her services for the Company or otherwise be injurious to the Company;
or (vi) the failure of the optionee to perform in a material respect his or her employment
obligations without proper cause. In making such determination, the Board of Directors shall act
fairly and in utmost good faith. For the purposes of this subsection (f), termination of
employment shall be deemed to occur when the optionee receives notice that his or her employment
is terminated.

          (g) If the Optionee’s engagement or employment with the Company terminates prior to the
Company’s first underwritten offering to the public pursuant to an

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effective registration statement under the Securities Act of 1933, as amended, then the Company
shall have the right and option to purchase, for a period of 180 days from the date of the
Optionee’s termination of engagement or employment, and if the Company exercises such right, the
Optionee shall be required to sell to the Company, any or all of the shares of Common Stock of the
Company granted hereunder at a price per share equal to the fair market value (determined by mutual
agreement between the Company and the Optionee or, in the absence of such agreement, by an
independent third party appraiser as of the date the Company exercises such right). If at any time
the Company elects to purchase shares pursuant to this Section 3(g), the closing of such purchase
shall take place at the offices of the Company within 30 days after delivery of notice to the
Optionee of the Company’s election to purchase such shares. The purchase price for such shares
shall be paid by delivery of a bank cashier’s check or certified check.

     4. Payment of Purchase Price

          (a) Method of Payment. Payment of the purchase price for shares purchased upon
exercise of this option shall be made (i) by delivery to the Company of cash or a certified or
bank check to the order of the Company in an amount equal to the purchase price of such shares,
(ii) subject to the consent of the Company, by delivery to the Company of shares of Common Stock
of the Company then owned by the Optionee having a fair market value equal in amount to the
purchase price of such shares, (iii) subject to the consent of the Company, by the delivery of an
assignment to the Company of a sufficient amount of the proceeds from the sale of the Common
Stock acquired upon exercise of this option and an authorization to the broker or selling agent
to pay that amount to the Company, which sale shall be at the Optionee’s direction at the time of
exercise, (iv) by any other means (including, without limitation, by delivery of a promissory
note of the Optionee payable on such terms as are specified by the Board of Directors) which the
Board of Directors determines are consistent with the purpose of the Plan and with applicable
laws and regulations (including, without limitation, the provisions of Rule l6b-3 under the
Securities Exchange Act of 1934 and Regulation T promulgated by the Federal Reserve Board), (v)
by the procedure set forth in Section 4(d) below, or (vi) by any combination of such methods of
payment.

          (b) Valuation of Shares or Other Non-Cash Consideration Tendered in Payment of Purchase
Price. For the purposes hereof, unless a recognized market value is available, the fair
market value of any share of the Company’s Common Stock or other non-cash consideration which may
be delivered to the Company in exercise of this option shall be determined in good faith by the
Board of Directors of the Company.

          (c) Delivery of Shares Tendered in Payment of Purchase Price. If the Optionee
exercises this option by delivery of shares of Common Stock of the Company, the certificate or
certificates representing the shares of Common Stock of the Company to be delivered shall be duly
executed in blank by the Optionee or shall be accompanied by a stock power duly executed in blank
suitable for purposes of transferring such shares to the Company. Fractional shares of Common
Stock of the Company will not be accepted in payment of the purchase price of shares acquired
upon exercise of this option.

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          (d) Net Issue Exercise. Prior to the closing of the Company’s first
underwritten offering to the public pursuant to an effective registration statement under the
Securities Act of 1933, as amended, in lieu of the payment provisions set forth in Section 4(a),
the Optionee may elect to exercise of this option by using the following formula:

X = Y(A-B)

      A

Where: X = The number of
shares of Common Stock to be issued to the Optionee.

            Y = The number of shares of Common Stock receivable upon exercise of this option (at the date of such calculation).

            A = The fair market value of one share of Common Stock (at the date of such calculation).

            B = The per share purchase price payable for one share of Common Stock upon exercise of this option.

     5. Delivery of Shares; Compliance With Securities Laws, Etc.

          (a) General. The Company shall, upon payment of the option price for the number of
shares purchased and paid for, make prompt delivery of such shares to
the Optionee; provided that if any law or regulation requires the Company to take any action with respect to such
shares before the issuance thereof, then the date of delivery of such shares shall be extended
for the period necessary to complete such action.

          (b) Listing, Qualification, Etc. This option shall be subject to the requirement
that if, at any time, counsel to the Company shall determine that the listing, registration or
qualification of the shares subject hereto upon any securities exchange or under any state or
federal law, or the consent or approval of any governmental or regulatory body, or that the
disclosure of non-public information or the satisfaction of any other condition is necessary as a
condition of, or in connection with, the issuance or purchase of shares hereunder, this option may
not be exercised, in whole or in part, unless such listing, registration, qualification, consent
or approval, disclosure or satisfaction of such other condition shall have been effected or
obtained on terms acceptable to the Board of Directors. Nothing herein shall be deemed to require
the Company to apply for, effect or obtain such listing, registration, qualification, or
disclosure, or to satisfy such other condition.

     6. Nontransferability of Option. This option is personal and no rights granted
hereunder may be transferred, assigned, pledged or hypothecated in any way (whether by operation
of law or otherwise) nor shall any such rights be subject to execution, attachment or similar
process except that this option may be transferred as provided in paragraph (e) of Section 3
above. Upon any attempt to transfer, assign, pledge, hypothecate or otherwise dispose of this
option or of such rights contrary to the provisions hereof, or upon the levy of any attachment or
similar process upon this option or such rights, this option and such rights shall, at the election
of the Company, become null and void.

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     7. No Special Employment Rights. Nothing contained in the Plan or this option
shall be construed or deemed by any person under any circumstances to bind the Company to
continue the employment of the Optionee for the period within which this option may be exercised,
or for any other period.

     8. Rights as a Shareholder. The Optionee shall have no rights as a shareholder with
respect to any shares which may be purchased by exercise of this option (including, without
limitation, any rights to receive dividends or non-cash distributions with respect to such shares)
unless and until a certificate representing such shares is duly issued and delivered to the
Optionee. No adjustment shall be made for dividends or other rights for which the record date is
prior to the date such stock certificate is issued.

     9. Adjustment Provisions

          (a) General. If, through, or as a result of, any merger, consolidation,
sale of all or substantially all of the assets of the Company, reorganization, recapitalization,
reclassification, stock dividend, stock split, reverse stock split or other similar transaction,
(i) the outstanding shares of Common Stock are increased, decreased or exchanged for a different
number or kind of shares or other securities of the Company, or (ii) additional shares or new or
different shares or other securities of the Company or other non-cash assets are distributed with
respect to such shares of Common Stock or other securities, the Optionee shall, with respect to
this option or any unexercised portion hereof, be entitled to the rights and benefits, and be
subject to the limitations, set forth in Section 15(a) of the Plan.

          (b) Board Authority to Make Adjustments. Any adjustments under this Section 9 will
be made by the Board of Directors, whose determination as to what adjustments, if any, will be
made and the extent thereof will be final, binding and conclusive. No fractional shares will be
issued pursuant to this option on account of any such adjustments,

          (c) Limits
on Adjustments. No adjustment shall be made under this Section 9 which
would, within the meaning of any applicable provision of the Code, constitute a modification,
extension or renewal of this option or a grant of additional benefits to the Optionee.

     10. Withholding Taxes. The Company’s obligation to deliver shares of Common Stock
upon the exercise of this option shall be subject to the Optionee’s satisfaction of all
applicable federal, state, local and foreign taxes of any kind required by law to be withheld with
respect to any shares issued upon exercise of this option. If the Company, in its discretion,
determines that it must or should withhold or pay over tax with respect to the exercise of this
option or a Disqualifying Disposition (as defined in Section 11 below) of shares of Common Stock
acquired by the Optionee on exercise of this option, the Optionee hereby agrees that, at the
option of the Company, Optionee will pay to the Company or the Company may withhold from the
Optionee’s wages the appropriate amount of federal, state, local and foreign taxes attributable
to such Disqualifying Disposition. If any portion of this option is treated as a non-qualified
option, the Optionee hereby agrees that, at the option of the Company, Optionee will pay to the
Company or the Company may withhold from the Optionee’s wages the appropriate amount of federal,
state, local and foreign taxes attributable to the Optionee’s exercise of such non-qualified

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option. At the Company’s discretion, the amount required to be withheld may be withheld in cash
from such wages, or (with respect to compensation income attributable to the exercise of this
option) in kind from the Common Stock otherwise deliverable to the Optionee on exercise of this
Option. The Optionee further agrees that, if the Company does not withhold an amount from the
Optionee’s wages sufficient to satisfy the Company’s withholding obligation, the Optionee will
reimburse the Company on demand, in cash, for the amount under withheld.

     11. Disqualifying Disposition. Although the parties intend that this option shall
qualify as an Incentive Stock Option, if this option is determined not to be an Incentive Stock
Option, the Optionee understands that the Company is not responsible to compensate the Optionee
or otherwise make up for the treatment of this option as a non-qualified stock option. The
Optionee should consult with the Optionee’s own tax advisors regarding the tax effects of this
option and the requirements necessary to obtain favorable treatment under the Code, including,
but not limited to, holding period requirements. The Optionee agrees to notify the Company in
writing immediately after the Optionee makes a Disqualifying Disposition (as such term is defined
in the Code) of any shares of Common Stock acquired pursuant to the exercise of this option. The
Optionee also agrees to provide the Company with any information which it shall request
concerning any such disposition. The Optionee acknowledges that he or she will forfeit the
favorable income tax treatment otherwise available with respect to the exercise of this Incentive
Stock Option if he or she makes a Disqualifying Disposition of the shares acquired on exercise of
this option.

     12. Investment
Representations; Legends; Limitations on Certain Dispositions

          (a) Representations. The Optionee represents, warrants and covenants that:

               (i) Any shares purchased upon exercise of this option shall be acquired for the
Optionee’s account for investment only and not with a view to, or for sale in connection
with, any distribution of the shares in violation of the Securities Act of 1933, as amended
(the “Securities Act”), or any rule or regulation under the Securities Act.

               (ii) The Optionee has had such opportunity as he or she has deemed adequate to
obtain from representatives of the Company such information as is necessary to permit the
Optionee to evaluate the merits and risks of his or her investment in the Company.

               (iii) The Optionee is able to bear the economic risk of holding shares acquired
pursuant to the exercise of this option for an indefinite period.

               (iv) The Optionee understands that (A) the shares acquired pursuant to the
exercise of this option will not be registered under the Securities Act and are “restricted
securities” within the meaning of Rule 144 under the Securities Act; (B) such shares cannot
be sold, transferred or otherwise disposed of unless they are subsequently registered under
the Securities Act or an exemption from registration is then available; (C) in any event, an
exemption from registration under Rule 144 or otherwise under the Securities Act may not be
available for at least one year and even then will not be available unless a public market
then exists for the Common Stock, adequate information

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concerning the Company is then available to the public and other terms and conditions of
Rule 144 are complied with; and (D) there is now no registration statement on file with the
Securities and Exchange Commission with respect to any stock of the Company and the Company
has no obligation or current intention to register any shares acquired pursuant to the
exercise of this option under the Securities Act.

     By making payment upon exercise of this option, the Optionee shall be deemed to have
reaffirmed, as of the date of such payment, the representations made in this Section 12.

          (b) Legends on Stock Certificates. All stock certificates representing shares of
Common Stock issued to the Optionee upon exercise of this option shall have affixed thereto
legends substantially in the following forms, in addition to any other legends required by
applicable law:

“The securities represented by this certificate have not been
registered under the Securities Act of 1933 and may not be
transferred, sold or otherwise disposed of in the absence of an
effective registration statement with respect thereto under the
Securities Act of 1933, or an opinion of counsel satisfactory to the
Company to the effect that registration under such Act is not
required.”

“The securities represented by this certificate are subject to
certain rights of repurchase and restrictions on transfer set forth
in the Incentive Stock Option Agreement between the Company and the
holder hereof pursuant to which such securities were issued. A copy
of such Agreement will be provided free of charge to the holder of
this certificate upon written request therefor addressed to the
Company.”

          (c) Limitations on Certain Dispositions. The Optionee agrees, by accepting
this option, that if the Company offers any of its Common Stock for sale pursuant to a
registration statement under the Securities Act, the Optionee will not, directly or indirectly,
without the prior written consent of the Company, sell, offer or agree to sell, grant any option to
purchase or otherwise transfer or dispose of any shares of Common Stock purchased upon exercise
of this option for a period of 180 days after the effective date of such registration statement.

     13. Interpretation of this Agreement. All decisions and interpretations made by the
Committee, as defined in Section 2 of the Plan, with regard to any question arising under the
Plan or this Agreement shall be binding and conclusive on the Company and the Optionee and any
other person entitled to exercise this option as provided herein. In the event there is any
inconsistency between the provisions of this Agreement and of the Plan, the provisions of the
Plan shall govern, subject to the provisions of section 2 above.

     14. Miscellaneous

          (a) Except as provided herein, this option may not be amended or otherwise modified
unless evidenced in writing and signed by the Company and the Optionee.

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          (b) All notices under this option shall be mailed or delivered by hand to the parties
at their respective addresses set forth beneath their names below or at such other address as may
be designated in writing by either of the parties to one another.

          (c) This option shall be governed by and construed in accordance with the laws of the State
of Delaware.

Date of Grant:

	 	 	 	 	 
	 	 	Avalon Pharmaceuticals, Inc.
	 
	 	 	 	 
	

	 	By:	 	 
	

	 	 	 	 

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OPTIONEE’S ACCEPTANCE

     The undersigned hereby accepts the foregoing option and agrees to the terms and conditions
thereof. The undersigned hereby acknowledges receipt of a copy of the Company’s Stock Plan.

	 	 	 
	

	 	OPTIONEE:
	 
	 	 
	

	 	 

9exv10w17

 

Exhibit 10.17

Avalon Pharmaceuticals, Inc.

Incentive Stock Option Agreement

     1. Grant of Option. Avalon Pharmaceuticals, Inc., a Delaware corporation (the
“Company”) hereby grants to                                         , an individual whose address is set forth below
the optionee signature line (the “Optionee”), an option, pursuant to the Company’s Amended and
Restated 1999 Stock Plan as of October 15, 2001 (the “Plan”), to purchase an aggregate of
                    shares of common stock of the Company (“Common Stock”) at a price of $.40 per share,
purchasable as set forth in and subject to the terms and conditions of this option and the Plan.
Except where the context otherwise requires, the term “Company” shall include the parent and all
present and future subsidiaries of the Company as defined in Sections 424 (e) and 424(f) of the
Internal Revenue Code of 1986, as amended or replaced from time to time (the “Code”).

     2. Incentive Stock Option. This option is intended to qualify as an incentive stock
option (“Incentive Stock Option”) within the meaning of Section 422 of the Code. Any provision
of this Agreement which conflicts with the requirements of qualification as an Incentive Stock
Option under the Code is null and void to the extent of such conflict and any ambiguities shall
be resolved so that this option qualifies as an Incentive Stock Option.

     3. Exercise of Option and Provisions for Termination.

          (a) Vesting Schedule. Except as otherwise provided in this Agreement, this option
may be exercised as to the number of shares indicated opposite the respective dates on Schedule A
hereto (“Vested Shares”). This option may not be exercised with respect to any shares after the
tenth anniversary of the date of grant (hereinafter the “Expiration Date”).

          (b) Exercise Procedure. Subject to the conditions set forth in this Agreement, this
option shall be exercised by the Optionee’s delivery of written notice of exercise to the
Company, specifying the number of shares to be purchased and the purchase price to be paid
therefore and accompanied by payment in full in accordance with Section 4. Such exercise shall be
effective upon receipt by the Company of such written notice together with the required payment.
The Optionee may purchase less than the number of shares covered hereby, provided that no partial
exercise of this option may be for any fractional share or for less than one whole share.

          (c) Continuous Employment Required. Except as otherwise provided in this Section 3,
this option may not be exercised unless the Optionee, at the time he or she exercises this
option, is, and has been at all times since the date of grant of this option, an employee of the
Company. For all purposes of this option, (i) “employment” shall be defined in accordance with
the provisions of Section 1.421-7(h) of the Income Tax Regulations or any successor regulations,
and (ii) if this option shall be assumed or a new option substituted therefor in a transaction to
which Section 424(a) of the Code applies, employment by such assuming or substituting corporation
(hereinafter called the “Successor Corporation”) shall be considered for all purposes of this
option to be employment by the Company.

 

 

          (d) Exercise Period Upon Termination of Employment. If the Optionee ceases to be
employed by the Company for any reason, then, except as provided in paragraphs (e) and (f) below,
the right to exercise this option shall terminate three months after such cessation (but in no
event after the Expiration Date), provided that this option shall be exercisable only to the
extent that the Optionee was entitled to exercise this option on the date of such cessation.
Notwithstanding the foregoing, if the Optionee, prior to the Expiration Date, materially violates
any non-competition or confidentiality provisions of any agreement between the Optionee and the
Company, the right to exercise this option shall terminate immediately upon such violation.

          (e) Exercise Period Upon Death or Disability. If the Optionee dies or becomes
disabled (within the meaning of Section 22(e)(3) of the Code) prior to the Expiration Date while
he or she is an employee of the Company, or if the Optionee dies within three months after the
Optionee ceases to be an employee of the Company (other than as the result of a discharge for
“cause” as specified in paragraph (f) below), this option shall be exercisable, within the period
of one year following the date of death or disability of the Optionee (but in no event after the
Expiration Date), by the Optionee or by the person to whom this option is transferred by will or
the laws of descent and distribution; provided that this option shall be exercisable only to the
extent that this option was exercisable by the Optionee on the date of his or her death or
disability. Except as otherwise indicated by the context, the term “Optionee”, as used in this
option, shall be deemed to include the estate of the Optionee or any person who acquires the
right to exercise this option by bequest or inheritance or otherwise by reason of the death of the
Optionee.

          (f) Termination for Cause. If the Optionee, prior to the Expiration Date, ceases
his or her employment with the Company because he or she is terminated for “Cause” (as defined
below), the right to exercise this option shall terminate immediately upon such cessation of
employment. “Cause” is conduct, as determined by the Board of Directors, involving one or more of
the following: (i) gross misconduct by the Optionee which is materially injurious to the Company;
or (ii) the commission of an act of embezzlement, fraud or deliberate disregard of the rules or
policies of the Company which results in material economic loss, damage or injury to the Company;
or (iii) the unauthorized disclosure of any trade secret or confidential information of the
Company or any third party who has a business relationship with the Company or the violation of
any noncompetition covenant or assignment of inventions obligation with the Company; or (iv) the
commission of any act which induces any customer or prospective customer of the Company to break
a contract with the Company or to decline to do business with the Company; or (v) the conviction
of the Optionee of a felony involving any financial impropriety or which would materially
interfere with the Optionee’s ability to perform his or her services for the Company or otherwise
be injurious to the Company; or (vi) the failure of the optionee to perform in a material respect
his or her employment obligations without proper cause. In making such determination, the Board
of Directors shall act fairly and in utmost good faith. For the purposes of this subsection
(f), termination of employment shall be deemed to occur when the optionee receives notice that
his or her employment is terminated.

          (g) Buy Back Rights. If the Optionee, prior to the Expiration Date, ceases his or
her employment or engagement with the Company because he or she is terminated for Cause, pursuant
to paragraph (f) of this Section 3, prior to the Company’s first underwritten offering to

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the public pursuant to an effective registration statement under the Securities Act of
1933, as amended, then the Company shall have the right and option to purchase, for a period of
180 days from the date of the Optionee’s termination of engagement or employment, and if the
Company exercises such right, the Optionee shall be required to sell to the Company, any or all of
the shares of Common Stock of the Company which may have been granted hereunder as a result of a
previous exercise,_at a price per share equal to the fair market value (determined by mutual
agreement between the Company and the Optionee or, in the absence of such agreement, by an
independent third party appraiser as of the date the Company exercises such right). If at any time
the Company elects to purchase shares pursuant to this Section 3(g), the closing of such purchase
shall take place at the offices of the Company within 30 days after delivery of notice to the
Optionee of the Company’s election to purchase such shares. The purchase price for such shares
shall be paid by delivery of a bank cashier’s check or certified check. This provision 3(g) shall
survive the exercise or partial exercise of this Option.

     4. Payment of Purchase Price

          (a) Method of Payment. Payment of the purchase price for shares purchased upon
exercise of this option shall be made (i) by delivery to the Company of cash or a certified or
bank check to the order of the Company in an amount equal to the purchase price of such shares,
(ii) subject to the consent of the Company, by delivery to the Company of shares of Common Stock
of the Company then owned by the Optionee having a fair market value equal in amount to the
purchase price of such shares, (iii) subject to the consent of the Company, by the delivery of an
assignment to the Company of a sufficient amount of the proceeds from the sale of the Common
Stock acquired upon exercise of this option and an authorization to the broker or selling agent
to pay that amount to the Company, which sale shall be at the Optionee’s direction at the time of
exercise, (iv) by any other means (including, without limitation, by delivery of a promissory
note of the Optionee payable on such terms as are specified by the Board of Directors) which the
Board of Directors determines are consistent with the purpose of the Plan and with applicable
laws and regulations (including, without limitation, the provisions of Rule 16b-3 under the
Securities Exchange Act of 1934 and Regulation T promulgated by the Federal Reserve Board), (v)
by the procedure set forth in Section 4(d) below, or (vi) by any combination of such methods of
payment.

          (b) Valuation of Shares or Other Non-Cash Consideration Tendered in Payment of Purchase Price. For the purposes hereof, unless a recognized market
value is available, the fair market value of any share of the Company’s Common Stock or other non-cash
consideration which may be delivered to the Company in exercise of this option shall be determined
in good faith by the Board of Directors of the Company.

          (c) Delivery of Shares Tendered in Payment of Purchase Price. If the Optionee
exercises this option by delivery of shares of Common Stock of the Company, the certificate or
certificates representing the shares of Common Stock of the Company to be delivered shall be duly
executed in blank by the Optionee or shall be accompanied by a stock power duly executed in blank
suitable for purposes of transferring such shares to the Company. Fractional shares of Common
Stock of the Company will not be accepted in payment of the purchase price of shares acquired
upon exercise of this option.

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          (d) Net Issue Exercise. Prior to the closing of the Company’s first underwritten offering to the public pursuant to an effective registration statement under the
Securities Act of 1933, as amended, in lieu of the payment provisions set forth in Section 4(a),
the Optionee may elect to exercise of this option by using the following formula:

X = Y (A – B)

     A

Where: X = The number of shares of Common Stock to be issued to the Optionee.

          Y = The number of shares of Common Stock receivable upon exercise of this option (at the date of such calculation).

          A = The fair market value of one share of Common Stock (at the date of such calculation).

          B
= The per share purchase price payable for one share of Common Stock upon exercise of this option.

     5. Delivery of Shares; Compliance With Securities Laws, Etc.

          (a) General. The Company shall, upon payment of the option price for the
number of shares purchased and paid for, make prompt delivery of such shares to the Optionee;
provided that if any law or regulation requires the Company to take any action with respect
to such shares before the issuance thereof, then the date of delivery of such shares shall be
extended for the period necessary to complete such action.

          (b) Listing,
Qualification, Etc. This option shall be subject to the requirement
that if, at any time, counsel to the Company shall determine that the listing, registration or
qualification of the shares subject hereto upon any securities exchange or under any state or
federal law, or the consent or approval of any governmental or regulatory body, or that the
disclosure of non-public information or the satisfaction of any other condition is necessary as a
condition of, or in connection with, the issuance or purchase of shares hereunder, this option may
not be exercised, in whole or in part, unless such listing, registration, qualification, consent
or approval, disclosure or satisfaction of such other condition shall have been effected or
obtained on terms acceptable to the Board of Directors. Nothing herein shall be deemed to require
the Company to apply for, effect or obtain such listing, registration, qualification, or
disclosure, or to satisfy such other condition.

     6. Nontransferability of Option. This option is personal and no rights granted
hereunder may be transferred, assigned, pledged or hypothecated in any way (whether by operation
of law or otherwise) nor shall any such rights be subject to execution, attachment or similar
process except that this option may be transferred as provided in paragraph (e) of Section 3
above. Upon any attempt to transfer, assign, pledge, hypothecate or otherwise dispose of this
option or of such rights contrary to the provisions hereof, or upon the levy of any attachment or
similar process upon this option or such rights, this option and such rights shall, at the election
of the Company, become null and void.

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     7. No
Special Employment Rights. Nothing contained in the Plan or this option
shall be construed or deemed by any person under any circumstances to bind the Company to
continue the employment of the Optionee for the period within which this option may be exercised,
or for any other period.

     8. Shareholder Rights

     (a) No Rights as a Shareholder until Exercise. The Optionee shall have no rights as a
shareholder with respect to any shares which may be purchased by exercise of this option
(including, without limitation, any rights to receive dividends or non-cash distributions with
respect to such shares) unless and until a certificate representing such shares is duly issued and
delivered to the Optionee, No adjustment shall be made for dividends or other rights for which
the record date is prior to the date such stock certificate is issued.

     (b) Transfer Restrictions on Underlying Stock . This Option is subject to the
requirement that upon exercise, the underlying security exchanged for the Option, shall be
subject to all of the transfer restrictions set forth in the Plan including but not limited those
requirements set forth in Paragraph 13 of the Plan entitled “Stock Transfer Restrictions on
Underlying Stock,” “Right of First Refusal” and “Drag Along Rights,” and in Paragraph 21 of the
Plan entitled “Lock-Up,” and as may be set forth in the by-laws of the Company. The Optionee
agrees to be bound by these restrictions and further agrees, upon the request of the Company to
execute any further documentation necessary to evidence said agreement. An Optionee’s failure to
execute same, at the Company’s request, shall cause the Option, and/or the underlying security to
be immediately null and void. The Company shall be free to place a legend on the back of the
underlying security specifying the foregoing restrictions.

     9. Adjustment Provisions

          (a) General. If, through, or as a result of, any merger, consolidation, sale of all
or substantially all of the assets of the Company, reorganization, recapitalization,
reclassification, stock dividend, stock split, reverse stock split or other similar transaction,
(i) the outstanding shares of Common Stock are increased, decreased or exchanged for a different
number or kind of shares or other securities of the Company, or (ii) additional shares or new or
different shares or other securities of the Company or other non-cash assets are distributed with
respect to such shares of Common Stock or other securities, the Optionee shall, with respect to
this option or any unexercised portion hereof, be entitled to the rights and benefits, and be
subject to the limitations, set forth in Section 15(a) of the Plan.

          (b) Board Authority to Make Adjustments. Any adjustments under this Section 9
will be made by the Board of Directors, whose determination as to what adjustments, if any, will
be made and the extent thereof will be final, binding and conclusive. No fractional shares will
be issued pursuant to this option on account of any such adjustments.

          (c) Limits on Adjustments. No adjustment shall be made under this Section 9 which
would, within the meaning of any applicable provision of the Code, constitute a modification,
extension or renewal of this option or a grant of additional benefits to the Optionee.

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     10. Withholding Taxes. The Company’s obligation to deliver shares of Common Stock
upon the exercise of this option shall be subject to the Optionee’s satisfaction of all
applicable federal, state, local and foreign taxes of any kind required by law to be withheld with
respect to any shares issued upon exercise of this option. If the Company, in its discretion,
determines that it must or should withhold or pay over tax with respect to the exercise of this
option or a Disqualifying Disposition (as defined in Section 11 below) of shares of Common Stock
acquired by the Optionee on exercise of this option, the Optionee hereby agrees that, at the
option of the Company, Optionee will pay to the Company or the Company may withhold from the
Optionee’s wages the appropriate amount of federal, state, local and foreign taxes attributable
to such Disqualifying Disposition. If any portion of this option is treated as a non-qualified
option, the Optionee hereby agrees that, at the option of the Company, Optionee will pay to the
Company or the Company may withhold from the Optionee’s wages the appropriate amount of federal,
state, local and foreign taxes attributable to the Optionee’s exercise of such non-qualified
option. At the Company’s discretion, the amount required to be withheld may be withheld in cash
from such wages, or (with respect to compensation income attributable to the exercise of this
option) in kind from the Common Stock otherwise deliverable to the Optionee on exercise of this
Option. The Optionee further agrees that, if the Company does not withhold an amount from the
Optionee’s wages sufficient to satisfy the Company’s withholding obligation, the Optionee will
reimburse the Company on demand, in cash, for the amount under withheld.

     11. Disqualifying Disposition. Although the parties intend that this option shall
qualify as an Incentive Stock Option, if this option is determined not to be an Incentive Stock
Option, the Optionee understands that the Company is not responsible to compensate the Optionee
or otherwise make up for the treatment of this option as a non-qualified stock option. The
Optionee should consult with the Optionee’s own tax advisors regarding the tax effects of this
option and the requirements necessary to obtain favorable treatment under the Code, including,
but not limited to, holding period requirements. The Optionee agrees to notify the Company in
writing immediately after the Optionee makes a Disqualifying Disposition (as such term is defined
in the Code) of any shares of Common Stock acquired pursuant to the exercise of this option.
The Optionee also agrees to provide the Company with any information which it shall request
concerning any such disposition. The Optionee acknowledges that he or she will forfeit the
favorable income tax treatment otherwise available with respect to the exercise of this Incentive
Stock Option if he or she makes a Disqualifying Disposition of the shares acquired on exercise of
this option.

     12. Investment
Representations; Legends; Limitations on Certain Dispositions

          (a) Representations. The Optionee represents, warrants and covenants that:

          (i) Any shares purchased upon exercise of this option shall be acquired for the
Optionee’s account for investment only and not with a view to, or for sale in connection
with, any distribution of the shares in violation of the Securities Act of 1933, as amended
(the “Securities Act”), or any rule or regulation under the
Securities Act.

          (ii) The Optionee has had such opportunity as he or she has deemed adequate to obtain
from representatives of the Company such information as is

6

 

necessary to
permit the Optionee to evaluate the merits and risks of his or her investment in the Company.

          (iii) The Optionee is able to bear the economic risk of holding shares acquired
pursuant to the exercise of this option for an indefinite period.

          (iv) The Optionee understands that (A) the shares acquired pursuant to the exercise of
this option will not be registered under the Securities Act and are “restricted securities”
within the meaning of Rule 144 under the Securities Act; (B) such shares cannot be sold,
transferred or otherwise disposed of unless they are subsequently registered under the
Securities Act or an exemption from registration is then available; (C) in any event, an
exemption from registration under Rule 144 or otherwise under the Securities Act may not be
available for at least one year and even then will not be available unless a public market
then exists for the Common Stock, adequate information concerning the Company is then
available to the public and other terms and conditions of Rule 144 are complied with; and
(D) there is now no registration statement on file with the Securities and Exchange
Commission with respect to any stock of the Company and the Company has no obligation or
current intention to register any shares acquired pursuant to the exercise of this option
under the Securities Act.

     By making payment upon exercise of this option, the Optionee shall be deemed to have
reaffirmed, as of the date of such payment, the representations made in this Section 12.

          (b) Legends on Stock Certificates. All stock certificates representing shares of
Common Stock issued to the Optionee upon exercise of this option shall have affixed thereto
legends substantially in the following forms, in addition to any other legends required by
applicable law:

“The securities represented by this certificate have not been
registered under the Securities Act of 1933 and may not be
transferred, sold or otherwise disposed of in the absence of an
effective registration statement with respect thereto under the
Securities Act of 1933, or an opinion of counsel satisfactory to the
Company to the effect that registration under such Act is not
required.”

“The securities represented by this certificate are subject to
certain rights of repurchase and restrictions on transfer set forth
in the Amended and Restated 1999 Stock Plan as of October 15, 2001
and in the Incentive Stock Option Agreement between the Company and
the holder hereof pursuant to which such securities were issued. A
copy of such Agreement will be provided free of charge to the holder
of this certificate upon written request therefor addressed to the
Company.”

          (c) Limitations on Certain Dispositions. The Optionee agrees, by accepting
this option, that if the Company offers any of its Common Stock for sale pursuant to a
registration statement under the Securities Act, the Optionee will not, directly or indirectly,
without the prior written consent of the Company, sell, offer or agree to sell, grant any option to
purchase or otherwise transfer or dispose of any shares of Common Stock purchased upon exercise
of this option for a period of 180 days after the effective date of such registration statement.

7

 

     13. Interpretation of this Agreement. All decisions and interpretations made
by the Committee, as defined in Section 2 of the Plan, with regard to any question arising under
the Plan or this Agreement shall be binding and conclusive on the Company and the Optionee and
any other person entitled to exercise this option as provided herein. In the event there is any
inconsistency between the provisions of this Agreement and of the Plan, the provisions of the
Plan shall govern, subject to the provisions of section 2 above.

     14. Miscellaneous

          (a) Except as provided herein, this option may not be amended or otherwise modified unless
evidenced in writing and signed by the Company and the Optionee.

          (b) All notices under this option shall be mailed or delivered by hand to the parties at
their respective addresses set forth beneath their names below or at such other address as may be
designated in writing by either of the parties to one another.

          (c) This option shall be governed by and construed in accordance with the laws of the State
of Delaware.

Date of Grant:

	 	 	 	 	 	 	 
	 	 	Avalon Pharmaceuticals, Inc.
	 
	 	 	 	 	 	 
	

	 	By:	 	 	 	 
	 	 	 	 	 
	

	 	 	 	 	 	Kenneth C. Carter, Ph.D.
	

	 	 	 	 	 	President and CEO

8

 

OPTIONEE’S ACCEPTANCE

     The undersigned hereby accepts the foregoing option and agrees to the terms and conditions
thereof. The undersigned hereby acknowledges receipt of a copy of the Company’s Amended and
Restated 1999 Stock Plan as of October 15, 2001.

	 	 	 
	

	 	OPTIONEE:
	 
	 	 
	

	 	 

9

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