Document:

EXHIBIT
      10.4

     

    SCIENTIFIC
      ADVISORY AGREEMENT

    AMENDMENT
      NO. 1

    

    This
      Amendment No. 1 (this “Amendment”) effective this 24th day of August, 2004
      hereby amends that certain Scientific Advisory Agreement (the “Agreement”)
      between ARIE BELLDEGRUN, M.D., having an address at 10833 Le Conte Avenue,
      Los
      Angeles, CA 90095 (hereinafter referred to as "ADVISOR") and Cougar
      Biotechnology, Inc., a Delaware limited liability corporation having offices
      at
      10940 Wilshire Blvd. Suite 600, Los Angeles, CA 90024 ("COUGAR"). Capitalized
      terms used herein but not otherwise defined shall have the meaning ascribed
      to
      such term in the Agreement.

    

    WHEREAS,
      the ADVISOR and COUGAR have previously entered into the Agreement;

    

    WHEREAS,
      COUGAR desires to increase the amount of time that the ADVISOR commits to
      providing advisory functions; and

    

    WHEREAS,
      the ADVISOR desires to provide such increased advisory functions.

    

    NOW,
      THEREFORE, based upon the mutual premises and conditions contained herein,
      the
      parties hereby agree as follows:

     

    1. Section
      3
      is hereby amended and restated in its entirety to read as follows:

    

    Section
      3. Advisory
      Function.
      ADVISOR
      agrees to be available during the term of this Agreement upon reasonable request
      by COUGAR to consult with COUGAR and to assist COUGAR in the assessment of
      research, development and commercial programs of biotechnology or pharmaceutical
      companies that COUGAR may consider developing or acquiring from time to time,
      to
      offer advice and guidance with respect to the research and commercial
      development plans of potential competitors of such companies; provided, however,
      that ADVISOR shall not be obligated to commit more than two days per week to
      COUGAR. ADVISOR also agrees to be available, upon reasonable notice, to attend
      all meetings of the SAB and the Board.

    

    2. Section
      4(a) is hereby amended and restated in its entirety to read as
      follows:

    

    (a) Pay
      to
      ADVISOR Two Hundred Thousand Dollars ($200,000) per year payable in accordance
      with its normal payroll period and practices;

    

    3. In
      addition, in consideration for such additional services, the Company has agreed
      to grant to you options (the “Additional Options”) to purchase an additional
      100,000 shares of Common Stock of the Company at an exercise price equal to
      $0.15 per share, which Additional Options shall vest, if at all, in four equal
      amounts on each anniversary of this Agreement and shall otherwise be subject
      to
      the Employee Stock Option Plan of COUGAR. Except as provided in Section 1 of
      the
      Agreement and the following sentence, the Additional Options shall vest only
      if
      ADVISOR is a member of both the Board of Directors and the SAB on such vesting
      date. Notwithstanding the foregoing, any portion of the Additional Options
      remaining unvested shall vest upon a Change of Control. “Change of Control”
means (i) the acquisition, directly or indirectly, following the date hereof
      by
      any person (as such term is defined in Section 13(d) and 14(d)(2) of the
      Securities Exchange Act of 1934, as amended), in one transaction or a series
      of
      related transactions, of securities of the Company representing in excess of
      fifty percent (50%) or more of the combined voting power of the Company’s then
      outstanding securities if such person or his or its affiliate(s) do not own
      in
      excess of 50% of such voting power on the date of this Agreement, or (ii) the
      future disposition by the Company (whether direct or indirect, by sale of assets
      or stock, merger, consolidation or otherwise) of all or substantially all of
      its
      business and/or assets in one transaction or series of related transactions
      (other than a merger effected exclusively for the purpose of changing the
      domicile of the Company).

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

     

    IN
      WITNESS WHEREOF,
      the
      parties hereto have executed this Agreement by proper person thereunto duly
      authorized.

    

    
       

      
        	 	 	 
	 	 	COUGAR BIOTECHNOLOGY, INC.
	 
 	 
 	 
 
	 	 	/s/
                Alan
                H. Auerbach
	 	
                 

                 

                 

              	
                
                  

                

                By:  Alan H. Auerbach, CEO

                Date:  

              
	 	 

      

      
        	 	 	 
	 	
                
                   

                

              	
                ARIE
                  BELLDEGRUN, M.D

              
	 
 	 
 	 
 
	 	 	/s/
                Arie
                Belldegrun
	 	
                 

                  
                  

              	
                

                Name: 
                  Arie Belldegrun

                Title:EXHIBIT
      10.5

     

    August
      5,
      2004

    

    Mr.
      Charles R. Eyler

    3125
      Collingswood Drive 

    El
      Dorado
      Hills, CA 95762 

    

    Dear
      Mr.
      Eyler:

    

    This
      letter (the “Letter”) shall confirm our understanding as to the terms of your
      employment as Vice President of Finance for Cougar Biotechnology, Inc.
      (“Cougar”) should you accept such a position with Cougar.

    

    
      	 	
              1.

            	
              You
                shall receive an annual base salary equal to One Hundred Forty Thousand
                Dollars ($140,000.00), payable in accordance with Cougar’s normal payroll
                practices. Your employment shall commence on August 23, 2004 (the
                “Commencement Date”).

            

    

    

    
      	 	
              2.

            	
              At
                the sole discretion of Cougar’s Board of Directors (the “Board”), you
                shall receive an additional annual bonus of up to 50% of your base
                salary
                (the “Discretionary Bonus”), the amount of which shall also be determined
                solely by the Board and shall be based upon your performance on behalf
                of
                Cougar during the prior year. The Discretionary Bonus, if any, shall
                be
                payable either as a lump-sum payment or in installments as determined
                by
                the Board in its sole discretion.

            

    

    

    
      	 	
              3.

            	
              As
                additional compensation for the services to be rendered by you pursuant
                to
                this Agreement, Cougar shall grant you stock
                options (“Stock
                Options”)
                to purchase 100,000 shares of Cougar’s common stock, par value $0.001 per
                share (the “Common Stock”) at an exercise price equal to $1.50.
                The
                Stock Options shall be governed by Cougar’s 2003 Stock Option Plan and
                shall
                vest, if at all,
                in two equal installments, on each of the first two anniversaries
                of your
                employment with Cougar. In
                connection with such grant, you shall enter into Cougar’s standard stock
                option agreement, which will incorporate the foregoing vesting
                schedule. 

            

    

    

    
      	 	
              4.

            	
              You
                shall be reimbursed for all of your pre-approved out-of-pocket expenses
                incurred in connection with Cougar’s business. Cougar will also reimburse
                you for your relocation expenses, up to an amount of Fifteen Thousand
                Dollars ($15,000.00); provided, however, that if your employment
                with
                Cougar is terminated prior to the first anniversary of the Commencement
                Date you shall return any such relocation
                reimbursement.

            

    

     

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

     

    
      	 	
              5.

            	
              You
                will be entitled to participate in the group medical coverage pursuant
                to
                the group policy of Cougar.

            

    

    

    
      	 	
              6.

            	
              Your
                employment shall be on an at-will basis and will be subject to, and
                you
                will be required to sign (a) Cougar’s employee manual and (b) a
                confidentiality, inventions and non-compete
                agreement.

            

    

    

    If
      you
      find the foregoing arrangement acceptable and believe that the foregoing
      accurately summarizes our understanding, please kindly so indicate by executing
      and dating the attached copy of this Letter in the space provided and returning
      a copy to me.

    

    

                 Very
      truly
      yours,

     

     

    
      	 	 	 
	 	 	Cougar Biotechnology, Inc.
	 
 	 
 	 
 
	 	 	By:  /s/ Alan
              H. Auerbach
	 	
              

              Name: Alan
                H. Auerbach

              Title: Chief
                Executive Officer

            

    

     

    
    

     

    
      Agreed
        and Accepted:

      

      
        	 	 	 	 
	By: 
                /s/ Charles R. Eyler	 	 	 
	
                
Name: 
Charles
                R. Eyler	 	 	
              
	Date:

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