Document:

EX-10.3

 Exhibit 10.3 
  

			
	Nur die deutsche Fassung ist rechtsverbindlich	  	Only the German version is legally binding
		
	 1. Nachtrag

zum Geschäftsführer-

Anstellungsvertrag
	  	 1st amendment to the

Managing Director

Agreement

		
	Es wird die nachfolgende Änderung vereinbart mit Wirkung zum 16. Oktober 2015 in Ziffer 2.1. im Geschäftsführer-Anstellungsvertrag zwischen	  	The following change is agreed on with effect as of 16 October 2015 in Clause 2.1 of the Managing Director Agreement between
	
	 Karyopharm Europe GmbH

Franziska-Bilek-Weg 9, 80339 München/ Munich

Deutschland/ Germany
 - im
folgenden Arbeitgeber genannt - / - hereinafter referred to as Employer -
  

und/ and
  

Herrn/ Mr
 Ran Frenkel

HaTamar Street 3, Yehud-Monosson

Israel
 - im folgenden
Geschäftsführer genannt - /
 - hereinafter referred to as Managing
Director–

		
	2. Vertragsdauer	  	2. Term of Agreement
		
	 2.1   Die Befristung des bestehenden Geschäftsführer-Anstellungsvertrags
wird verlängert.
  
 Der
Geschäftsführer-Anstellungsvertrag endet ohne dass es einer Kündigung bedarf am 31. Dezember 2015.
	  	 2.1   The fixed term of the Managing Director Agreement will be prolonged.

 
 The Managing Director Agreement ends without notice of termination at
the end of 31 December 2015.

		
	Alle anderen Vereinbarungen des Geschäftsführer-Anstellungsvertrags bleiben unverändert.	  	All other clauses of the Managing Director Agreement remain unchanged.

  

			
	 Newton, MA, USA 15-Oct-2015
 Ort, Datum/
Place, Date
	  	 Tel Aviv 15/10/2015
 Ort, Datum/ Place,
Date

  

							
				
	 /s/ Christopher B. Primiano

Für den Arbeitgeber/ for the Employer
	 		  	 /s/ Ran Frenkel

Für den Geschäftsführer/
 for the Managing
DirectorEX-10.4

 Exhibit 10.4 

FIRST AMENDMENT 
 TO

 CONSULTING AGREEMENT 

BETWEEN 
 KARYOPHARM
THERAPEUTICS 
 AND 

MIRZA CONSULTING 
 WHEREAS,
Karyopharm Therapeutics Inc. (“Karyopharm”) and Mirza Consulting (“Consultant”) previously entered into a Consulting Agreement effective as of September 1, 2012 (the “Agreement”); 

WHEREAS, the Term of the Agreement was set to commence on the Effective Date and scheduled to terminate on August 31, 2015; 

WHEREAS, the Compensation to Consultant was set such that the initial fee of $10,000 per month was to increase effective January 1, 2013
to $16,000 per month; 
 WHEREAS, the Parties now agree to extend the Agreement for an additional one year; and 

WHEREAS, the Parties now agree to amend the Consulting Fees payable to Consultant. 

NOW, THEREFORE, the Agreement is modified as follows: 
  

	1.	Section 2 is hereby revised to read: “Term. This Agreement shall commence on the date hereof and shall continue until August 31, 2016 (such period, as it may be extended or sooner terminated
in accordance with the provisions of Section 4, being referred to as the “Consultation Period”). 

  

	2.	Section 3.1 is hereby revised to read: “Consulting Fees. The Company shall pay to the Consultant a consulting fee of $10,000 per month to be increased to $16,000 per month effective
January 1, 2013 and to be increased to $22,500 per month effective January 1, 2015. Payment for any partial month shall be prorated.” 

Except as specifically amended by this First Amendment, the terms and conditions of the Agreement shall remain in full force and effect. 

IN WITNESS WHEREOF, this First Amendment is effective as of September 1, 2015. 
  

									
	KARYOPHARM THERAPEUTICS INC.	 		 	MIRZA CONSULTING
					
	Signature	 	/s/ Christopher B. Primiano	 		 	Signature	 	/s/ Mansoor Raza Mirza, MD
	Name:	 	Christopher B. Primiano	 		 	Name:	 	Mansoor Raza Mirza, MD
	Title:	 	SVP, Corporate Development & General Counsel	 		 		 	

  
 Page 1 of 1EX-10.5

 Exhibit 10.5 

SECOND AMENDMENT TO LEASE 

This Second Amendment to Lease (this “Second Amendment”) is entered into as of October 22, 2015, by and between NS
WELLS ACQUISITION LLC, a Delaware limited liability company (the “Landlord”), and KARYOPHARM THERAPEUTICS INC., a Delaware corporation (the “Tenant”). 

WHEREAS, Landlord and Tenant entered into that certain Office Lease Agreement dated as of March 27, 2014, as amended by a First Amendment
to Lease dated December 31, 2014 (the “First Amendment”) (as amended, the “Lease”) for the lease of certain premises containing 29,933 rentable square feet (the “Existing Premises”) on the
second (2nd) floor and certain premises containing 16,234 rentable square feet on the third (3rd) floor (the “Expansion
Premises”) of the building located at 85 Wells Avenue, Newton, MA 02459 (the “Building”), and commonly known as 75-95 Wells Avenue; 

WHEREAS, the Expansion Premises consists of “Expansion Premises A” containing 8,468 rentable square feet and
“Expansion Premises B” containing 7,766 rentable square feet; 
 WHEREAS, due a scrivener’s error, the Base Rent
charts for the Existing Premises and the Expansion Premises set forth in the First Amendment incorrectly included a reference to an Extension Lease Year 2 for the Existing Premises and a Lease Year 8 for the Expansion Premises; 

WHEREAS, Landlord and Tenant desire to amend the Lease to (i) correct the foregoing discrepancy, (ii) to restate the Base Rent
charts for the Existing Premises and the Expansion Premises, and (iii) to confirm the Commencement Dates and Rent Commencement Dates for the Expansion Premises, and the Extended Termination Date of the Lease, as set forth herein; and 

WHEREAS, Landlord and Tenant desire to amend Section 4.B (Landlord’s Expansion Premises Contribution) of the First Amendment to
provide for the payment of the Allowance in four installments in lieu of the payment method provided in said section. 
 NOW, THEREFORE, in
consideration of the foregoing and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant agree that the Lease is hereby amended as follows: 

1. Confirmation of Dates. Landlord and Tenant hereby confirm and agree that: 

(i) The Expansion Premises A Commencement Date is January 1, 2015, and the Expansion Premises A Rent Commencement Date is
May 1, 2015; 
 (ii) The Expansion Premises B Commencement Date is June 1, 2015, and the Expansion Premises B Rent
Commencement Date is October 1, 2015; and 
 (iii) The Extended Termination Date of the Lease is September 30,
2022. 

  
 1 

 2. Existing Premises. Section 1A(i) of the First Amendment is hereby deleted in its
entirety, and the below-listed Base Rent chart is hereby substituted therefor: 
  

	 	(i)	Base Rent. 

  

													
	 Period
	  	Annual Base
Rent	 	  	Monthly
Base Rent	 	  	Per Rentable
Square Foot	 
	 12/1/21 – 9/30/22
	  	$	942,889.50	* 	  	$	78,574.13	  	  	$	31.50	  

  

	*	Annualized 

 3. Expansion Premises A. Section 2B(i) of the First Amendment is hereby
deleted in its entirety, and the below-listed Base Rent chart is hereby substituted therefor: 
  

	 	(i)	Base Rent.  

  

													
	 Period
	  	Annual Base
Rent	 	  	Monthly
Base Rent	 	  	Per Rentable
Square Foot	 
	 1/1/15 – 4/30/15
	  	$	-0-	  	  	$	-0-	  	  	$	-0-	  
	 5/1/15 – 9/30/16
	  	$	241,338.00	* 	  	$	20,111.50	  	  	$	28.50	  
	 10/1/16 – 9/30/17
	  	$	245,572.00	  	  	$	20,464.33	  	  	$	29.00	  
	 10/1/17 – 9/30/18
	  	$	249,806.00	  	  	$	20,817.17	  	  	$	29.50	  
	 10/1/18 – 9/30/19
	  	$	254,040.00	  	  	$	21,170.00	  	  	$	30.00	  
	 10/1/19 – 9/30/20
	  	$	258,274.00	  	  	$	21,522.83	  	  	$	30.50	  
	 10/1/20 – 9/30/21
	  	$	262,508.00	  	  	$	21,875.67	  	  	$	31.00	  
	 10/1/21 – 9/30/22
	  	$	266,742.00	  	  	$	22,228.50	  	  	$	31.50	  

  

	*	Annualized 

 4. Expansion Premises B. Section 3B(i) of the First Amendment is hereby
deleted in its entirety, and the below-listed Base Rent chart is hereby substituted therefor: 
  

	 	(i)	Base Rent. 

  

													
	 Period
	  	Annual Base
Rent	 	  	Monthly
Base Rent	 	  	Per Rentable
Square Foot	 
	 6/1/15 – 9/30/15
	  	$	-0-	  	  	$	-0-	  	  	$	-0-	  
	 10/1/15 – 9/30/16
	  	$	221,331.00	  	  	$	18,444.25	  	  	$	28.50	  
	 10/1/16 – 9/30/17
	  	$	225,214.00	  	  	$	18,767.83	  	  	$	29.00	  
	 10/1/17 – 9/30/18
	  	$	229,097.00	  	  	$	19,091.42	  	  	$	29.50	  
	 10/1/18 – 9/30/19
	  	$	232,980.00	  	  	$	19,415.00	  	  	$	30.00	  
	 10/1/19 – 9/30/20
	  	$	236,863.00	  	  	$	19,738.58	  	  	$	30.50	  
	 10/1/20 – 9/30/21
	  	$	240,746.00	  	  	$	20,062.17	  	  	$	31.00	  
	 10/1/21 – 9/30/22
	  	$	244,629.00	  	  	$	20,385.75	  	  	$	31.50	  

  
 2 

 5. Landlord’s Expansion Premises Contribution. Notwithstanding anything set forth in
Section 4.B of the First Amendment to the contrary and provided Tenant furnishes Landlord with the required documentation set forth in said Section 4.B, Landlord shall disburse the Allowance of $568,190.00 to Tenant in four
(4) installments as set forth below: 
  

	 	•	 	1st Installment of $148,190.00: Paid; the receipt of which is hereby confirmed by Tenant 

 

	 	•	 	2nd Installment of $140,000.00: On or before October 30, 2015 

  

	 	•	 	3rd Installment of $140,000.00: On or before November 30, 2015 

  

	 	•	 	4th Installment of $140,000.00: On or before December 30, 2015 

Landlord hereby acknowledges that Landlord has received all documentation required under Section 4(B) of the First Amendment for all
disbursements of the Allowance including, without limitation, the 4th Installment, which is the final disbursement, and the installments required above shall be paid on the dates set forth above,
notwithstanding anything to the contrary contained in the Lease or in the First Amendment 
 6. Miscellaneous. 

A. This Second Amendment, together with the Lease, sets forth the entire agreement between the parties with respect to the matters set forth
herein. There have been no additional oral or written representations or agreements. Under no circumstances shall Tenant be entitled to any Rent abatement, improvement allowance, leasehold improvements, or other work to the Premises, or any similar
economic incentives that may have been provided Tenant in connection with entering into the Lease, unless specifically set forth in this Second Amendment. 

B. Except as herein modified or amended, the provisions, conditions and terms of the Lease shall remain unchanged and in full force and effect.

 C. In the case of any inconsistency between the provisions of the Lease and this Second Amendment, the provisions of this Second Amendment
shall govern and control. 
 D. Submission of this Second Amendment by Landlord is not an offer to enter into this Second Amendment but
rather is a solicitation for such an offer by Tenant. Landlord shall not be bound by this Second Amendment until Landlord has executed and delivered the same to Tenant. 

  
 3 

 E. The capitalized terms used in this Second Amendment shall have the same definitions as set
forth in the Lease to the extent that such capitalized terms are defined therein and not redefined in this Second Amendment. 
 F. Tenant
hereby represents to Landlord that Tenant has dealt with no broker in connection with this Second Amendment. Tenant agrees to indemnify and hold Landlord, its trustees, members, principals, beneficiaries, partners, officers, directors, employees,
mortgagee(s) and agents, and the respective principals and members of any such agents (collectively, the “Landlord Related Parties”) harmless from all claims of any brokers claiming to have represented Tenant in connection with this
Second Amendment. Landlord hereby represents to Tenant that Landlord has dealt with no broker in connection with this Second Amendment. Landlord agrees to indemnify and hold Tenant, its trustees, members, principals, beneficiaries, partners,
officers, directors, employees, and agents, and the respective principals and members of any such agents (collectively, the “Tenant Related Parties”) harmless from all claims of any brokers claiming to have represented Landlord in
connection with this Second Amendment. 
 G. Each signatory of this Second Amendment represents hereby that he or she has the authority to
execute and deliver the same on behalf of the party hereto for which such signatory is acting. 
 H. This Second Amendment may be executed in
any number of counterparts, and when each party has signed and delivered at least one such counterpart, each counterpart shall be considered an original, and when taken together with other signed counterparts, shall constitute one agreement, which
shall be binding upon and effective as to all parties. Facsimile and scanned signature shall be deemed originals for all purposes. 

[Signatures on following page] 

  
 4 

 EXECUTED under seal as of the date first above written. 

 

			
	LANDLORD:
	
	NS WELLS ACQUISITION LLC,
	a Delaware limited liability company
		
	By:	 	/s/ Joseph Adamo
		 	Name: Joseph Adamo
		 	Title: Joseph Adamo
	
	TENANT:
	
	 KARYOPHARM THERAPEUTICS INC.

a Delaware corporation

		
	By:	 	/s/ Justin A. Renz
		 	Name: Justin A. Renz
		 	Title: EVP, CFO & Treasurer

  
 5

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