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Exhibit 10.1    
    
    Execution Copy    
    

 
 

GTC BIOTHERAPEUTICS, INC.    
    
    SECURITIES PURCHASE AGREEMENT    
    
    dated as of July 30, 2003    

 
 

GTC BIOTHERAPEUTICS, INC.    
    
    SECURITIES PURCHASE AGREEMENT    
    

        This Securities Purchase Agreement (the "Agreement") is dated as of July 30, 2003 by and among GTC
Biotherapeutics, Inc., a Massachusetts corporation (the "Company"), and the Purchasers listed on the Schedule of Purchasers attached hereto as Exhibit A
(individually, a "Purchaser," and collectively, the "Purchasers"). 

 
 

RECITALS    
    

        A. In accordance with the terms and conditions of this Agreement and pursuant to exemptions from registration afforded by Rule 506 promulgated under the
Securities Act of 1933, as amended (the "Securities Act"), and Section 4(2) thereunder, the Company has agreed to issue and sell, and the Purchasers have severally
agreed to purchase the respective number of shares (collectively, the "Shares") of the common stock, par value $0.01 per share, of the Company (the "Common
Stock") and Common Stock Purchase Warrants to purchase shares of Common Stock (collectively, the "Warrant Shares") as is set forth on the Schedule of
Purchasers attached to this Agreement as Exhibit A (the Shares, the Common Stock Purchase Warrants and the Warrant Shares are herein referred to together as the
"Securities"); and 

        B.
Contemporaneously with the execution and delivery of this Agreement, the parties hereto are executing and delivering a Registration Rights Agreement substantially in the form attached
hereto as Exhibit B (as the same may be amended, modified or supplemented from time to time in accordance with the terms thereof, the "Registration
Rights Agreement") pursuant to which the Company has agreed to provide the Purchasers with the benefit of certain registration rights under the Securities Act and applicable state
securities laws, on the terms and subject to the conditions set forth therein; 

        NOW
THEREFORE, in consideration of the promises and the mutual covenants contained herein and other good and valuable consideration, the receipt and sufficiency of which are hereby
acknowledged, the Company and each of the Purchasers hereby agree as follows: 

        1.    Purchase and Sale.    

        (a)    Purchase of Common Stock.    At the Closing (as defined below), the Company shall
issue and sell to each Purchaser, and each Purchaser, severally and not jointly, shall purchase from the Company, shares of Common Stock in the respective amounts set forth opposite such Purchaser's
name on the Schedule of Purchasers attached hereto as Exhibit A, together with a Common Stock Purchase Warrant substantially in the form attached hereto as
Exhibit C (each a "Warrant" and collectively, the "Warrants"), pursuant to which such Purchaser shall have the right to acquire up to twenty-five
percent (25%) of the number of shares of Common Stock issued to such Purchaser, which shall be equal to the largest whole number of shares of Common Stock resulting from dividing the total number of
shares of Common Stock issued to such Purchaser at the Closing by four (4). The purchase price for each of the Shares shall be $2.55 (the "Purchase Price"). The exercise
price for the purchase of each of the Warrant Shares is set forth in the Warrants. 

        (b)    The Closing.    The date and time of the closing of the purchase and sale of the
Securities pursuant hereto (the "Closing") shall be 10:00 a.m., Eastern Standard Time, on August 1, 2003 (the "Closing Date"),
subject to the satisfaction or waiver of the conditions set forth in Sections 5 and 6 of this Agreement. The Closing shall occur at the offices of Palmer & Dodge LLP, 111 Huntington Avenue,
Boston, Massachusetts. 

        (c)    Form of Payment.    On the Closing Date, each Purchaser shall pay the Company the
Purchase Price for the Shares to be issued and sold to such Purchaser on the Closing Date, by wire transfer of immediately available funds in accordance with the Company's written wire instructions
attached hereto as Exhibit D. On the Closing Date, the Company shall deliver a facsimile copy to each Purchaser certificates registered in the name of such
Purchaser representing the number of Shares which such Purchaser is then purchasing hereunder and within 2 business days of the Closing, the 

 

Company
shall deliver to each Purchaser original certificates registered in the name of such Purchaser representing the number of Shares which such Purchaser is then purchasing hereunder and a Warrant
registered in the name of such Purchaser issued in accordance with Section 1(a) hereof. 

        2.    Purchaser's Representations and Warranties.    Each Purchaser represents and
warrants to the Company with respect to only itself that as of the date hereof and as of the Closing Date: 

        (a)    Investment Purpose.    Such Purchaser is acquiring the Securities for its own
account for investment only and not with a view towards, or for resale in connection with, the public sale or distribution thereof, without prejudice, however, to such Purchaser's right at all times
to sell or otherwise dispose of all or any part of such Securities in compliance with applicable federal and state securities laws.
Nothing contained herein shall be deemed a representation or warranty by such Purchaser to hold the Securities for any period of time.    Such Purchaser is acquiring the Securities
hereunder in the ordinary course of its business. Such Purchaser does not have any agreement or understanding, directly or indirectly, with any person to distribute any of the Securities. 

        (b)    Accredited Investor Status.    Such Purchaser is an "accredited investor" as that
term is defined in Rule 501(a) of Regulation D under the Securities Act and was not organized for the specific purpose of acquiring the Securities. Such Purchaser is not, nor is it
required to be, registered as a broker-dealer under Section 15 of the Exchange Act. 

        (c)    General Solicitation.    Such Purchaser is not purchasing the Securities as a
result of any advertisement, article, notice or other communication regarding the Securities published in any newspaper, magazine or similar media or broadcast over television or radio or presented at
any seminar or any other general solicitation or general advertisement. 

        (d)    Information.    Such Purchaser and its advisors, if any (i) has been
furnished with or believes it has had full access to all of the publicly available information that it considers necessary or appropriate for deciding whether to purchase the Securities,
(ii) has had an opportunity to ask questions and receive answers from the Company regarding the terms and conditions of the offering of the Securities, (iii) can bear the economic risk
of a total loss of its investment in the Securities and (iv) has such knowledge and experience in business and financial matters so as to enable it to understand the risks of and form an
investment decision with respect to its investment in the Securities. Neither such inquiries nor any other due diligence investigations conducted by such Purchaser or its advisors, if any, or its
representatives shall limit, modify, amend or affect the Company's representations and warranties contained in this Agreement or such Purchaser's right to rely thereon. 

        (e)    Reliance on Exemptions.    Such Purchaser understands that the Securities are
being offered and sold to it in reliance on specific exemptions from the registration requirements of the United States federal and state securities laws and that the Company is relying upon the truth
and accuracy of, and such Purchaser's compliance with, the representations, warranties, agreements, acknowledgments and understandings of such Purchaser set forth herein in order to determine the
availability of such exemptions and the eligibility of such Purchaser to acquire the Securities. 

        (f)    No Governmental Review.    Such Purchaser understands that no United States
federal or state agency or any other government or governmental agency has passed on or made any recommendation or endorsement of the Securities or the fairness or suitability of the investment in the
Securities nor have such authorities passed upon or endorsed the merits of the offering of the Securities. 

        (g)    Transfer or Resale.    Such Purchaser understands that, except as provided in the
Registration Rights Agreement, the Securities have not been registered under the Securities Act or any state securities laws, and may not be offered for sale, sold, assigned or transferred without
registration under the Securities Act or an exemption therefrom and that, in the absence of an effective registration statement under the Securities Act, such Securities may only be sold under certain
circumstances as set 

2

 

forth
in the Securities Act. In connection therewith, such Purchaser is aware of Rule 144 under the Securities Act and the restrictions imposed thereby. 

        (h)    Legend.    Such Purchaser understands that any certificate evidencing Securities
shall bear a legend in substantially the following form: 

[NEITHER
THESE SECURITIES NOR THE SECURITIES ISSUABLE UPON EXERCISE OF THESE SECURITIES HAVE BEEN] [THESE SECURITIES HAVE NOT BEEN] REGISTERED WITH THE
SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE "SECURITIES ACT"), AND,
ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO,
THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE WITH APPLICABLE STATE SECURITIES LAWS AS EVIDENCED BY A LEGAL OPINION OF COUNSEL TO THE TRANSFEROR TO SUCH EFFECT, THE SUBSTANCE
OF WHICH SHALL BE REASONABLY ACCEPTABLE TO THE COMPANY. THESE SECURITIES AND THE SECURITIES ISSUABLE UPON EXERCISE OF THESE SECURITIES MAY BE PLEDGED IN CONNECTION WITH A BONA FIDE MARGIN ACCOUNT
SECURED BY SUCH SECURITIES. 

        The
legend set forth above shall be removed and the Company shall issue the Securities without any such legends to the holder of the Securities, (i) if such Securities are
registered for resale under the Securities Act and have been transferred or sold pursuant to an effective registration statement, or (ii) if, in connection with a sale transaction, such holder
provides the Company with an opinion of counsel reasonably acceptable to the Company to the effect that such sale, assignment or transfer of the Securities may be made without registration under the
Securities Act. The Company shall not require such opinion of counsel for the sale of Securities in accordance with Rule 144 under the Securities Act, provided the Seller provides such
representations that the Company shall reasonably request confirming compliance with the requirements of Rule 144. The Company may not make any notation on its records or give instructions to
any transfer agent of the Company that enlarge the restrictions on transfer set forth in this Section. 

        (i)    Authorization; Enforcement; Validity.    Such Purchaser, if not an individual, is
an entity duly organized, validly existing and in good standing under the laws of the jurisdiction of its organization with full right,
corporate or partnership power and authority to enter into and to consummate the transactions contemplated by the this Agreement and the Registration Rights Agreement and otherwise to carry out its
obligations thereunder. The execution, delivery and performance by such Purchaser of the transactions contemplated by this Agreement has been duly authorized by all necessary corporate action on the
part of such Purchaser. This Agreement and the Registration Rights Agreement have been duly executed by such Purchaser, and when delivered by such Purchaser in accordance with terms hereof, will
constitute the valid and legally binding obligation of such Purchaser, enforceable against it in accordance with its terms, except as such enforceability may be limited by general principles of equity
or applicable bankruptcy, insolvency, reorganization, moratorium, liquidation or similar laws relating to, or affecting generally, the enforcement of creditors' rights and remedies. 

        (j)    Residency.    Such Purchaser, if an individual, is a resident of, or if an entity,
is organized under the laws of and with a principal office in, the country or state(s) specified on the Schedule of Purchasers attached hereto as Exhibit A. 

        (k)    No Conflicts.    The execution and performance of each of this Agreement and the
Registration Rights Agreement do not conflict with any agreement to which such Purchaser is a party 

3

 

or
is otherwise bound, any court order or judgment applicable to such Purchaser or, if applicable, the constituent documents of such Purchaser. 

        The
Company acknowledges and agrees that each Purchaser does not make or has not made any representations or warranties with respect to the transactions contemplated hereby other than
those specifically set forth in this Section 2. 

        3.    Representations and Warranties of the Company.    The Company represents and
warrants to each of the Purchasers that as of the date hereof and as of the Closing Date, subject to such exceptions as set forth in the Company's Disclosure Schedule attached hereto (the "Disclosure
Schedule") or as set forth in the SEC Documents (as defined below): 

        (a)    Organization and Qualification.    The Company and its
"Subsidiaries" (which, for purposes of this Agreement, means any entity (i) in which the Company, directly or indirectly, owns a majority of the capital stock or
other equity or similar interests and (ii) which holds assets that have a total book value exceeding $100,000) are corporations, partnerships or limited liability companies, as applicable, duly
organized, validly existing and in good standing under the laws of the jurisdictions in which they are incorporated or organized, and have the requisite corporate, partnership or limited liability
company, as applicable, power and authority to own their properties and to carry on their business as now being conducted and as described in the SEC Documents. Copies of the Company's Certificate of
Incorporation and Bylaws, and all amendments thereto, have been filed as exhibits to the Company's SEC Documents, are in full effect and have not been further modified. Each of the Company and its
Subsidiaries is duly qualified as a foreign corporation, partnership or limited liability company to do business and is in good standing in every jurisdiction in which its ownership of property or the
nature of the business conducted and proposed to be conducted by it makes such qualification necessary, except where the failure to be so qualified or in good standing would not, individually or in
the aggregate, have or reasonably be expected to result in a Material Adverse Effect. As used in this Agreement, "Material Adverse Effect" means any material adverse
effect on the business, properties, assets, operations, results of operations or financial condition of the Company and its Subsidiaries, taken as a whole, or on the transactions contemplated hereby
or by the agreements and instruments to be entered into in connection herewith, or on the authority or ability of the Company to perform on a timely basis its obligations under any Transaction
Document. A complete list of Subsidiaries is set forth in Section 3(a) of the Disclosure Schedule. 

        (b)    Authorization; Enforcement; Validity.    The Company has the requisite corporate
power and authority to enter into and perform its obligations under this Agreement, the Registration Rights Agreement, the Warrants and each of the other agreements entered into by the parties hereto
in connection with the transactions contemplated by this Agreement (collectively, the "Transaction Documents"), and to issue the Securities in accordance with the terms
hereof and thereof. The execution and delivery of the Transaction Documents by the Company and the consummation and performance by the Company of the transactions contemplated hereby and thereby,
including, without limitation, the issuance of the Securities, have been duly authorized by the Company's Board of Directors and no further consent or authorization is required of the Company's Board
of Directors or stockholders. The Transaction Documents have been duly executed and delivered by the Company. The Transaction Documents constitute the valid and binding obligations of the Company
enforceable against the Company in accordance with their respective terms, except as such enforceability may be limited by general principles of equity or applicable bankruptcy, insolvency,
reorganization, moratorium, liquidation or similar laws relating to, or affecting generally, the enforcement of creditors' rights and remedies. 

        (c)    Capitalization.    The capitalization of the Company is as described in the
Company's most recent periodic report filed with the Securities and Exchange Commission (the "Commission") as updated by any current report filed with the Commission thereafter. The Company has not
issued any 

4

 

capital
stock since such filings other than pursuant to the exercise of stock options under the Company's stock option plans, the issuance of shares of Common Stock to employees pursuant to the
Company's employee stock purchase plan (such issuances and any such stock options, whenever issued or granted, being collectively "Employee Equity Transactions"), pursuant to the conversion or
exercise of outstanding securities that are convertible into or exercisable for Common Stock, or pursuant to publicly disclosed equity financings. The Company's Common Stock is registered pursuant to
Section 12(b) of the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder (the "Exchange Act"), and is listed for
trading on the Nasdaq National Market. Except for Employee Equity Transactions and as set forth in the SEC Documents, (i) no shares of the Company's capital stock are subject to preemptive
rights or any other similar rights or any liens or encumbrances; (ii) there are no outstanding options, warrants, rights to subscribe to, calls or commitments of any character whatsoever
relating to, or securities or rights convertible into, any shares of capital stock of the Company or any of its Subsidiaries, or contracts, commitments, understandings or arrangements by which the
Company or any of its Subsidiaries is or may become bound to issue additional shares of capital stock of the Company or any of its Subsidiaries or options, warrants, rights to subscribe to, calls or
commitments of any character whatsoever relating to, or securities or rights convertible into, any shares of capital stock of the Company or any of its Subsidiaries. There are no securities or
instruments containing anti-dilution or similar provisions that will be triggered by the issuance of any of the Securities pursuant to the Transaction Documents. 

        (d)    Issuance of Securities.    The Securities are duly authorized and, upon issuance
in accordance with the terms hereof, will be (i) validly issued, fully paid and non-assessable and (ii) free from all taxes, liens and charges with respect to the issuance
thereof, other than any liens or encumbrances created by or imposed by the Purchasers, and not subject to preemptive rights or other similar rights of stockholders of the Company. The Company has
reserved from its duly authorized capital stock the maximum number of shares of Common Stock issuable pursuant to this Agreement and the Warrants in order to issue the full number of Warrant Shares as
are or may become issuable in accordance with the Warrants. 

        (e)    No Conflicts.    The execution, delivery and performance of the Transaction
Documents by the Company and the consummation by the Company of the transactions contemplated hereby and thereby do not and will not (i) result in a violation of the Company's Certificate of
Incorporation or Bylaws; (ii) conflict with, or constitute a default (or an event which with notice or lapse of time or both would become a default) under, or give to others any rights of
termination, amendment, acceleration or cancellation of, any agreement, indenture or instrument to which the Company or any of its Subsidiaries is a party; (iii) result in a violation of any
law, rule, regulation, order, judgment or decree applicable to the Company or any of its Subsidiaries or by which any property or asset of the Company or any of its Subsidiaries is bound or affected;
or (iv) result in the imposition of a mortgage, pledge, security interest, encumbrance, charge or other lien (whether arising by contract or operation of law) or any asset of the Company or its
Subsidiaries, except for such conflicts, defaults, terminations, amendments, accelerations, cancellations, violations and impositions as described in clauses (ii), (iii) or
(iv) of this sentence as would not, individually or in the aggregate, have or result in a Material Adverse Effect. 

5

   
        (f)    SEC Documents; Financial Statements.    Except as disclosed in the SEC Documents,
the Company has filed all reports, schedules, forms, statements and other documents required to be filed by it with the Securities and Exchange Commission (the
"Commission") pursuant to the reporting requirements of the Exchange Act for the twelve (12) months preceding the date hereof (all of the foregoing filed prior to
or on the date hereof and all exhibits included therein and financial statements and schedules thereto and documents incorporated by reference therein being referred to in this Agreement as the
"SEC Documents"). As of the date of filing of each such SEC Document, such SEC Document, as it may have been subsequently amended by filings made by the Company with the
SEC prior to the date hereof, complied in all material respects with the requirements of the Exchange Act and the rules and regulations of the Commission promulgated thereunder applicable to such SEC
Document. None of the SEC Documents, as of the date filed and as they may have been subsequently amended by filings made by the Company with the Commission prior to the date hereof, contained any
untrue statement of a material fact or omitted to state a material fact required to be stated therein or necessary in order to make the statements therein, in the light of the circumstances under
which they were made, not misleading. As of their respective dates, the financial statements of the Company included in the SEC Documents complied as to form in all material respects with applicable
accounting requirements and rules and regulations of the Commission with respect thereto. Such financial statements have been prepared in accordance with generally accepted accounting principles,
consistently applied in the United States, during the periods involved (except (i) as may be otherwise indicated in such financial statements or the notes thereto, or (ii) in the case of
unaudited interim statements, to the extent they may exclude footnotes, may be condensed or summary statements and may be subject to normal year-end adjustments that in the aggregate are
not material), correspond to the books and records of the Company and fairly present in all material respects the consolidated financial position of the Company as of the dates thereof and the results
of its operations and cash flows for the periods then ended. 

        (g)    Absence of Litigation.    Except as disclosed in the section titled "Legal
Proceedings" in the Company's Annual Report on Form 10-K for the year ended December 31, 2002, there is no action, suit, proceeding, inquiry or investigation before or by any
court, public board, government agency, self-regulatory organization or body pending or, to the knowledge of the Company or any of its Subsidiaries, threatened in writing against the
Company or any of the Subsidiaries or any of the Company's, (collectively, an "Action") which (i) adversely affects or challenges the legality, validity or enforceability of any of the
Transaction Documents or the Securities or (ii) would reasonably be expected to result in a Material Adverse Effect. 

        (h)    Regulatory Permits.    The Company and its Subsidiaries possess all material
certificates, authorizations and permits issued by the appropriate federal, state, local and foreign regulatory authorities necessary to conduct their respective businesses as described in the SEC
reports, except where the failure to possess such permits would not have or reasonably be expected result in a Material Adverse Affect (the "Permits"), and neither the Company nor any such Subsidiary
has received any notice relating to the revocation or modification of any such Permit. 

        (i)    Application of Takeover Protections.    The Company and its board of directors
have taken all necessary action, if any, in order to render inapplicable any control share acquisition, business combination, poison pill (including any distribution under a rights agreement) or other
similar anti-takeover provision under the Company's Certificate of Incorporation or Bylaws, the laws of the state of its incorporation, the laws of any other state or otherwise that is or
could become applicable to the Purchasers as a result of the transactions contemplated by this Agreement, including, without limitation, the Company's issuance of the Securities and the Purchasers'
ownership of the Securities in their respective amounts set forth on Exhibit A. 

        (j)    Transactions with Affiliates.    Except as disclosed in the SEC Documents, and
other than Employee Equity Transactions, none of the affiliates, officers, directors or employees of the Company is 

6

 

presently
a party to any agreement or transaction with the Company or any of its Subsidiaries (other than in connection with the provision of services as employees, officers and directors), including
without limitation any contract, agreement or other arrangement providing for the furnishing of services to or by, providing for rental of real or personal property to or from, or otherwise requiring
payments to or from any such affiliate, officer, director or employee or, to the knowledge of the Company, any corporation, partnership, trust or other entity in which any such affiliate, officer,
director, or employee has a material interest or is an officer, director, trustee or partner, such that the transaction would be required to be disclosed pursuant to Item 404 of
Regulation S-K promulgated under the Securities Act. 

        (k)    Brokers and Finders.    Except for fees payable to SG Cowen Securities Corporation
as placement agent (the "Placement Agent"), no brokers, finders or financial advisory fees or commissions will be payable by the Company with respect to the transactions contemplated by this Agreement
or the other Transaction Documents. 

        (l)    No Material Non-Public Information.    Except for the issuance of the
Securities and the transactions contemplated by this Agreement, neither the Company nor any person acting on its behalf has provided any of the Purchasers or their agents or counsel with any
information that the Company believes constitutes material, non-public information and the Company shall not at any time hereafter provide any of the Purchasers with any such information
unless such Purchaser shall have provided advance written consent thereto. The Company understands and confirms that the Purchasers will rely on the foregoing representations and covenants in
effecting transactions in securities of the Company. 

        (m)    Company not an "Investment Company".    The Company is not, and immediately after
receipt of payment for the Securities will not be, an "investment company" or an entity "controlled" by an "investment company" within the meaning of the Investment Company Act of 1940, as amended. 

        (n)    Certain Registration Matters.    Assuming the accuracy of the Purchasers'
representations and warranties set forth in Section 2(a)-(c), no registration under the Securities Act is required for the offer and sale of the Securities by the Company to the Purchasers
under the Transaction Documents. The Company is eligible to register the resale of its Common Stock for resale by the Purchasers under Form S-3 promulgated under the Securities Act. 

        (o)    Listing and Maintenance Requirements.    The Company has not, in the two years
preceding the date hereof, received notice from the Nasdaq Stock Market to the effect that the Company is not in compliance with the listing or maintenance requirements thereof. The Company is, and
has no reason to believe that it will not in the foreseeable future continue to be, in compliance with the listing and maintenance requirements for continued listing of the Common Stock on the Nasdaq
National Market. The issuance and sale of the Securities hereunder does not contravene the rules and regulations of the Nasdaq Stock Market and no approval of the shareholders of the Company is
required for the Company to issue and deliver to the Purchasers the number of Securities contemplated by the Transaction Documents. 

        4.    Covenants.    

        (a)    Obligations.    Each party shall use its best efforts to timely satisfy each of
the conditions to be satisfied by such party as provided in Sections 5 and 6 of this Agreement. 

        (b)    Reporting Status.    With a view to making available to the Investors (as that
term is defined in the Registration Rights Agreement) the benefits of Rule 144 promulgated under the Securities Act or any similar rule or regulation of the Commission that may at any time
permit the Investors to sell securities of the Company to the public without registration ("Rule 144"), and in addition to any requirements contained in the
Registration Rights Agreement, the Company shall use its best efforts: (i) make and keep public information available, as those terms are understood and defined in Rule 144;
(ii) file with the Commission in a timely manner all reports and other documents required of the Company under the Securities Act and the Exchange Act; and (iii) furnish to each
Investor, so long 

7

 

as
such Investor owns Registrable Securities (as that term is defined in the Registration Rights Agreement), promptly upon request, (A) a written statement by the Company that it has complied
with the applicable reporting requirements of Rule 144, the Securities Act and the Exchange Act and (B) such other information as may be reasonably requested to permit the Investors to
sell such securities pursuant to Rule 144 without registration under the Securities Act. 

        (c)    Use of Proceeds.    The Company intends to use the net proceeds from the sale of
the Securities for working capital and general corporate purposes. 

        (d)    Listing.    The Company shall promptly use its best efforts to secure the listing
of all of the Shares, and upon their issuance, the Warrant Shares, upon each national securities exchange and automated quotation system, if any, upon which shares of Common Stock are then listed
(subject to official notice of issuance) and, shall maintain, so long as any other shares of Common Stock shall be so listed, such listing of all Securities from time to time issuable under the terms
of the Transaction Documents. So long as any Securities are outstanding, the Company shall maintain the Common Stock's authorization for quotation or listing on The Nasdaq National Market (the
"Principal Market"). 

        (e)    Filing of Form 8-K.    By 9:30 a.m. on the first
Business Day following the Closing Date, the Company shall file a Current Report on Form 8-K with the Commission describing the terms of the transactions contemplated by the
Transaction Documents in the form required by the Exchange Act. "Business Day" means any day other than Saturday, Sunday or other day on which commercial banks in the City
of New York are required by law to remain closed. Notwithstanding the foregoing, the Company shall not publicly disclose the name of any Purchaser, or include the name of any Purchaser in any filing
with the Commission (other than the Registration Statement and any exhibits to filings made in respect of this transaction in accordance with filing requirements under the Exchange Act) or any
regulatory agency or securities exchange, without the prior written consent of such Purchaser, except to the extent such disclosure is required by law or securities exchange regulations. 

        (f)    Violation of Laws.    The business of the Company and its Subsidiaries shall not
be conducted in violation of any law, ordinance or regulation of any governmental entity, except where such violations would not result, either individually or in the aggregate, in a Material Adverse
Effect. 

        5.    Conditions to the Company's Obligation to Close.    The obligation of the Company
to issue and sell the Securities at the Closing is subject to the satisfaction, at or before the Closing Date, of each of the following conditions with respect to each Purchaser, provided that these
conditions are for the Company's sole benefit and may be waived by the Company at any time in its sole discretion by providing the Purchasers with prior written notice thereof: 

        (a)    Transaction Documents.    Each Purchaser shall have executed each of the
Transaction Documents to which it is a party and delivered the same to the Company. 

        (b)    Payment of Purchase Price.    Each Purchaser shall have delivered to the Company
the Purchase Price for the Securities being purchased by such Purchaser at the Closing, by wire transfer of immediately available funds pursuant to the wire instructions attached hereto as
Exhibit C. 

        (c)    Representations and Warranties; Covenants.    The representations and warranties
of each Purchaser shall be true, correct and complete in all material respects (except to the extent that any of such representations and warranties is already qualified as to materiality in
Section 2 above, in which case such representations and warranties shall be true, correct and complete without further qualification) as of the date when made and as of the Closing Date as
though made at that time (except for representations and warranties that speak as of a specific date, which shall be true, correct and complete as of such date), and each Purchaser shall have
performed, satisfied and complied with the covenants, agreements and conditions required by the Transaction Documents to be performed, satisfied or complied with by such Purchaser at or prior to the
Closing Date. 

8

 

        6.    Conditions to Each Purchaser's Obligation to Purchase.    The obligation of each
Purchaser hereunder to purchase the Securities set forth opposite such Purchaser's name on Exhibit A attached hereto from the Company at the Closing is subject to
the satisfaction, at or before the Closing Date, of each of the following conditions, provided that these conditions are for each Purchaser's sole benefit and may be waived by such Purchaser (solely
as to itself) at any time in its sole discretion by providing the Company with prior written notice thereof: 

        (a)    Transaction Documents.    The Company shall have executed each of the Transaction
Documents and delivered the same to such Purchaser. 

        (b)    No Delisting of Common Stock.    The Common Stock (i) shall be designated
for quotation or listed on the Principal Market and (ii) shall not have been suspended by the Commission or the Principal Market from trading on the Principal Market nor shall suspension by the
Commission or the Principal Market have been threatened (nor, as applicable, to the Company's knowledge shall there be no reasonable basis for any such suspension) either (A) in writing by the
Commission or the Principal Market or (B) by falling below the minimum listing maintenance requirements of the Principal Market. 

        (c)    Representations and Warranties; Covenants.    The representations and warranties
of the Company shall be true, correct and complete in all material respects (except to the extent that any of such representations and warranties is already qualified as to materiality in
Section 3 of this Agreement, in which case such representations and warranties shall be true, correct and complete without further qualification) as of the date when made and as of the Closing
Date as though made at that time (except for representations and warranties that speak as of a specific date, which shall be true, correct and complete as of such date) and the Company shall have
performed, satisfied and complied with in all material respects the covenants, agreements and conditions required by the Transaction Documents to be performed, satisfied or complied with by the
Company at or prior to the Closing Date. Such Purchaser shall have received a certificate (which may be a facsimile copy), executed by the Chief Executive Officer and Chief Financial Officer of the
Company, dated as of the Closing Date, to the foregoing effect. 

        (d)    Opinion of Counsel.    The Company shall have delivered to such Purchaser the
opinion of Palmer & Dodge LLP (which may be a facsimile copy), counsel to the Company, dated as of the Closing Date, in the form previously provided to the Purchasers. 

        (e)    Filings: Authorizations.    The Company shall have made all filings under all
applicable federal and state securities laws necessary to consummate the issuance of the Securities pursuant to this Agreement in compliance with such laws, and shall have obtained all authorizations,
approvals and permits necessary to consummate the transactions contemplated by the Transaction Documents, and such authorizations, approvals and permits shall be effective as of the Closing Date. 

        (f)    No Injunctions.    No temporary restraining order, preliminary or permanent
injunction or other order or decree, and no other legal restraint or prohibition shall exist which prevents or arguably prevents the consummation of the transactions contemplated by the Transaction
Documents, nor shall any proceeding have been commenced or threatened with respect to the foregoing. 

        (g)    No Material Adverse Effect.    Between the time of execution of this Agreement and
the Closing Date, no Material Adverse Effect shall occur or become known (whether or not arising in the ordinary course of business). 

        (h)    Minimum Subscription.    The Company shall have received subscriptions for cash
payment for not less than Eight Million Dollars ($8,000,000) of Shares. 

9

 

        (i)    Closing Date.    The Closing Date shall occur not later than August 5,
2003. 

        7.    Miscellaneous.    

        (a)    Governing Law; Jurisdiction; Jury Trial.    All questions concerning the
construction, validity, enforcement and interpretation of this Agreement shall be governed by the internal laws of the State of New York, without giving effect to any choice of law or conflict of law
provision or rule (whether of the State of New York or any other jurisdictions) that would cause the application of the laws of any jurisdictions other than the State of New York. Each party hereby
irrevocably submits to the non-exclusive jurisdiction of the state and federal courts sitting in the City of New York, Borough of Manhattan, for the adjudication of any dispute hereunder
or in connection herewith or with any transaction contemplated hereby or discussed herein, and hereby irrevocably waives, and
agrees not to assert in any suit, action or proceeding, any claim that it is not personally subject to the jurisdiction of any such court, that such suit, action or proceeding is brought in an
inconvenient forum or that the venue of such suit, action or proceeding is improper. Each party hereby irrevocably waives personal service of process and consents to process being served in any such
suit, action or proceeding by mailing a copy thereof to such party at the address for such notices to it under this Agreement and agrees that such service shall constitute good and sufficient service
of process and notice thereof. Nothing contained herein shall be deemed to limit in any way any right to serve process in any manner permitted by law. If any provision of this Agreement shall be
invalid or unenforceable in any jurisdiction, such invalidity or unenforceability shall not affect the validity or enforceability of the remainder of this Agreement in that jurisdiction or the
validity or enforceability of any provision of this Agreement in any other jurisdiction. EACH PARTY HEREBY IRREVOCABLY WAIVES ANY RIGHT IT MAY HAVE, AND AGREES NOT TO REQUEST, A JURY TRIAL FOR THE
ADJUDICATION OF ANY DISPUTE HEREUNDER OR IN CONNECTION HEREWITH OR ARISING OUT OF THIS AGREEMENT OR ANY TRANSACTION CONTEMPLATED HEREBY. 

        (b)    Counterparts.    This Agreement may be executed in identical counterparts, each of
which shall be deemed an original but all of which shall constitute one and the same agreement. This Agreement, once executed by a party, may be delivered to the other parties hereto by facsimile
transmission of a copy of this Agreement bearing the signature of the party so delivering this Agreement. 

        (c)    Headings.    The headings of this Agreement are for convenience of reference only
and shall not limit or otherwise affect the meaning hereof. 

        (d)    Entire Agreement.    This Agreement, the Registration Rights Agreement, the
Warrants and the documents referenced herein and therein constitute the entire agreement among the parties hereto with respect to the subject matter hereof and thereof. There are no restrictions,
promises, warranties or undertakings, other than those set forth or referred to herein and therein. This Agreement, the Registration Rights Agreement, the Warrants and the documents referenced herein
and therein supersede all prior agreements and understandings among the parties hereto with respect to the subject matter hereof and thereof. 

        (e)    Consents.    All consents and other determinations required to be made by
Purchasers pursuant to this Agreement shall be made, unless otherwise specified in this Agreement, by Purchasers holding at least a majority of the Securities then outstanding held by Purchasers. 

        (f)    Waivers.    No provision of this Agreement may be amended or waived other than by
an instrument in writing signed by the Company and by Purchasers holding at least a majority of the Securities held by Purchasers then outstanding. No such amendment shall be effective to the extent
that it applies to less than all of the holders of the Securities then outstanding. No consideration shall be offered or paid to any Purchaser to amend or consent to a waiver or modification of any
provision 

10

 

of
any of the Transaction Documents unless the same consideration also is offered to all of the Purchasers. 

        (g)    Notices.    Any notices, consents, waivers or other communications required or
permitted to be given under the terms of this Agreement must be in writing and will be deemed to have been delivered: (i) upon receipt, when delivered personally; (ii) upon receipt, when
sent by facsimile (provided confirmation of transmission is mechanically or electronically generated and kept on file by the sending party); or (iii) one (1) Business Day after deposit
with a nationally recognized overnight delivery service, in each case properly addressed to the party to receive the same. The addresses and facsimile numbers for such communications shall be: 

        If
to the Company: 

GTC
Biotherapeutics, Inc.

175 Crossing Boulevard

Suite 410

Framingham, MA 01702

Telephone: (508) 270-2061

Facsimile: (508) 271-3491

Attention: Geoffrey F. Cox, Ph.D.

                  Chairman, President and CEO 

        with
a copy to: 

Palmer
& Dodge LLP

111 Huntington Avenue

Boston, MA 02199`

Telephone: (617) 239-0100

Facsimile: (617) 227-4420

Attention: Nathaniel Gardiner, Esq. 

        If
to Placement Agent: 

SG
Cowen Securities Corporation

1221 Avenue of the Americas

New York, NY 10020

Telephone: (212) 278-6000

Facsimile: (212) 278-5503

Attention: David Stadinski 

        If
to a Purchaser, to its address and facsimile number set forth on the Schedule of Purchasers attached hereto as Exhibit A, with copies to such
Purchaser's representatives as set forth on the Schedule of Purchasers, or at such other address or facsimile number or to the attention of such other person as the recipient party has specified by
written notice given to each other party five (5) days prior to the effectiveness of such change. Written confirmation of receipt (A) given by the recipient of such notice, consent,
waiver or other communication, (B) mechanically or electronically generated by the sender's facsimile machine containing the time, date, recipient facsimile number and an image of the first
page of such transmission, or (C) provided by a courier or overnight courier service shall be rebuttal evidence of personal service, receipt by facsimile or receipt from a nationally recognized
overnight delivery service in accordance with clause (i), (ii) or (iii) above, respectively. 

        (h)    No Strict Construction.    The language used in this Agreement will be deemed to
be the language chosen by the parties to express their mutual intent, and no rules of strict construction will be applied against any party. 

11

 

        (i)    Further Assurances.    Each party shall do and perform, or cause to be done and
performed, all such further acts and things, and shall execute and deliver all such other agreements, certificates, instruments and documents, as the other party may reasonably request in order to
carry out the intent and accomplish the purposes of this Agreement and the consummation of the transactions contemplated hereby. 

        (j)    Third-Party Beneficiaries.    This Agreement is intended for the benefit of the
parties hereto and their respective permitted successors and assigns, and is not for the benefit of, nor may any provision hereof be enforced by, any other person other than Placement Agent. 

        (k)    Severability.    If any provision of this Agreement shall be invalid or
unenforceable in any jurisdiction, such invalidity or unenforceability shall not affect the validity or enforceability of the remainder of this Agreement in that jurisdiction or the validity or
enforceability of any provision of this Agreement in any other jurisdiction. 

        (l)    Successors and Assigns.    This Agreement shall be binding upon and inure to the
benefit of the parties and their respective successors and assigns, including any purchasers of the Securities. The Company shall not assign this Agreement or any rights or obligations hereunder
without the prior written consent of the holders of at least a majority of the Securities then outstanding. Subject to restrictions on transfer referenced in Section 2 of this Agreement, a
Purchaser may assign all of its rights and obligations hereunder with respect to some or all or its Securities without the consent of the Company; provided, however, that the transferee has agreed in
writing to be bound by the applicable provisions of this Agreement and that such assignment shall be in connection with a transfer of all or a portion of the Securities held by such Purchaser. 

        (m)    Survival.    Unless this Agreement is terminated under Section 7(q) of this
Agreement, the representations and warranties of the Company and the Purchasers contained in Sections 2 and 3 of this Agreement shall survive for a period of two years from the Closing Date. Each
Purchaser shall be responsible only for its own representations, warranties, agreements and covenants hereunder. 

        (n)    Publicity.    The Company shall issue a press release regarding the occurrence of
this transaction prior to 9:00 a.m. on the first Business Day following the date of this Agreement. Subject to Section 4(e), the Company and Placement Agent shall have the right to
approve before issuance any press releases or any other public statements with respect to the transactions contemplated by the Transaction Documents. The Placement Agent has the right to describe its
services to the Company in connection with this transaction and to reproduce the Company's name and logo in Placement Agent's advertisements, marketing materials and equity research reports, if any,
in the form previously approved by the Company and subject to the prior approval of the Company, which shall not be unreasonably withheld or delayed. 

        (o)    Expenses.    The Company shall pay all fees and expenses it incurs in connection
with satisfying its obligations under this Agreement. The Company shall also reimburse the Purchasers, up to a maximum of twenty five thousand dollars ($25,000) in the aggregate for all of the
Purchasers, for the Purchasers' reasonable out-of-pocket expenses, including, without limitation, fees of legal counsel, incurred by them in connection with the consummation of
the transactions contemplated by this Agreement and for which such Purchasers submit invoices to the Company within thirty (30) days of the Closing Date. To be eligible for reimbursement an
invoice must be accompanied by an itemized list and reasonable documentation of all such expenses. If eligible invoices for such expenses exceed $25,000 in the aggregate, then the Company shall
reimburse each Purchaser a percentage of its expenses incurred in an amount that is pro rata to the dollar amount such Purchaser paid for the Securities hereunder. 

        (p)    Limitation on Issuances of Securities.    During the six months following the
Closing Date, the Company shall not issue any "Future Priced Securities" as such term is described by NASD IM-4350-1. 

12

 

        (q)    Termination.    In the event that the Closing shall not have occurred on or before
three (3) Business Days from the date hereof due to the Company's or a Purchaser's failure to satisfy the conditions set forth in Sections 5 and 6 of this Agreement (and the nonbreaching
party's failure to waive such unsatisfied conditions), the nonbreaching party shall have the option to terminate this Agreement with respect to such breaching party at the close of business on such
date without liability of any party to any other party. 

        (r)    Remedies.    Each Purchaser and each holder of the Securities shall have all
rights and remedies set forth in the Transaction Documents, all rights and remedies that such holders have been granted at any time under any other agreement or contract and all of the rights which
such holders have under any law. Any person having any rights under any provision of this Agreement shall be entitled to enforce such rights to recover damages by reason of any breach of any provision
of this Agreement and to exercise all other rights granted by law. Furthermore, the Company recognizes that in the event that it fails to perform, observe, or discharge any or all of its obligations
under this Agreement, any remedy at law may prove to be inadequate relief to the Purchasers. The Company therefore agrees that the Purchasers shall be entitled to seek temporary and permanent
injunctive relief in any such case without the necessity of proving actual damages and without posting a bond or other security. 

        (s)    Independent Nature of Purchasers' Obligations and Rights.    The obligations of
each Purchaser under any Transaction Document are several and not joint with the obligations of any other Purchaser, and no Purchaser shall be responsible in any way for the performance of the
obligations of any other Purchaser under any Transaction Document. Nothing contained herein or in any Transaction Document, and no action taken by any Purchaser pursuant thereto, shall be deemed to
constitute the Purchasers as a partnership, an association, a joint venture or any other kind of entity, or create a presumption that the Purchasers are in any way acting in concert or as a group with
respect to such obligations or the transactions contemplated by the Transaction Document. Each Purchaser shall be entitled to independently protect and enforce its rights, including without limitation
the rights arising out of this Agreement or out of the other Transaction Documents, and it shall not be necessary for any other Purchaser to be joined as an additional party in any proceeding for such
purpose. 

[Remainder
of page intentionally left blank.] 

13

        IN WITNESS WHEREOF, the parties have caused this Securities Purchase Agreement to be duly executed as of the date first written above. 

	 	 	COMPANY:
	

 	
 	

GTC Biotherapeutics, Inc.
	

 	
 	

By:	

/s/  JOHN B. GREEN      
 John B. Green

Senior Vice President, Chief Financial Officer and Treasurer

[Signatures
of Purchasers on Following Page] 

	 	 	PURCHASER:
	

 	
 	

BAYSTAR CAPITAL II, LP, a Delaware limited partnership
	

 	
 	

By:	

BayStar Capital Management, LLC, its general partner
	

 	
 	

By:	

/s/  STEVEN M. LAMAR      

	 	 	Name:	Steven M. Lamar
	 	 	Title:	Managing Member
	

 	
 	

c/o BayStar Capital Management, LLC

80 E. Sir Francis Drake Blvd., Suite 2B

Larkspur, California 94939

Tel: (415) 834-4600

Fax: (415) 834-4601

Attn: Steven Lamar

[Signature
Page to Securities Purchase Agreement of GTC Biotherapeutics, Inc.] 

	 	 	PURCHASER:
	

 	
 	

CASTLE CREEK HEALTHCARE

PARTNERS LLC
	

 	
 	

By:	

/s/  THOMAS A. FREI      
 Name: Thomas A. Frei

Title: Managing Director of the Investment Manager

[Signature
Page to Securities Purchase Agreement of GTC Biotherapeutics, Inc.] 

	 	 	PURCHASER:
	

 	
 	

CLARION CAPITAL CORPORATION
	

 	
 	

By:	

/s/  MORTON COHEN      
 Name: Morton Cohen

Title: Chairman

[Signature
Page to Securities Purchase Agreement of GTC Biotherapeutics, Inc.] 

	 	 	PURCHASER:
	

 	
 	

DEEPHAVEN SMALL CAP GROWTH FUND LLC
	

 	
 	

By:	

/s/  BRUCE LIEBERMAN      
 Name: Bruce Lieberman

Title: Director of Private Placements

[Signature
Page to Securities Purchase Agreement of GTC Biotherapeutics, Inc.] 

	 	 	PURCHASER:
	

 	
 	

GRYPHON MASTER FUND, LP
	

 	
 	

By:	

/s/  E.B. LYON IV      
 Name: E.B. Lyon IV

Title: Authorized Agent

[Signature
Page to Securities Purchase Agreement of GTC Biotherapeutics, Inc.] 

	 	 	PURCHASER:
	

 	
 	

CAPITAL VENTURES INTERNATIONAL
	

 	
 	

By:	

Heights Capital Management, Inc., its authorized agent
	

 	
 	

By:	

/s/  MARTIN KOBINGER      
 Name: Martin Kobinger

Title: Investment Manager

[Signature
Page to Securities Purchase Agreement of GTC Biotherapeutics, Inc.] 

	 	 	PURCHASER:
	

 	
 	

SMITHFIELD FIDUCIARY LLC
	

 	
 	

By:	

/s/  ADAM J. CHILL      
 Name: Adam J. Chill

Title: Authorized Signatory

[Signature
Page to Securities Purchase Agreement of GTC Biotherapeutics, Inc.] 

	 	 	PURCHASER:
	

 	
 	

MIDSUMMER INVESTMENT, LTD.
	

 	
 	

By:	

/s/  MICHAEL A. AMSALEM      

	 	 	Name:	Michael A. Amsalem
	 	 	Title:	Director

[Signature
Page to Securities Purchase Agreement of GTC Biotherapeutics, Inc.] 

	 	 	PURCHASER:
	

 	
 	

ALL AMERICA – SMALL CAP GROWTH FUND
	

 	
 	

By:	

/s/  THOMAS P. LARSEN      

	 	 	Name:	Thomas P. Larsen
	 	 	Title:	EVP Mutual of America Capital Mgt.

[Signature
Page to Securities Purchase Agreement of GTC Biotherapeutics, Inc.] 

	 	 	PURCHASER:
	

 	
 	

INSTITUTIONAL AGGRESSIVE EQUITY GROWTH FUND
	

 	
 	

By:	

/s/  THOMAS P. LARSEN      

	 	 	Name:	Thomas P. Larsen
	 	 	Title:	EVP Mutual of America Capital Mgt.

[Signature
Page to Securities Purchase Agreement of GTC Biotherapeutics, Inc.] 

	 	 	PURCHASER:
	

 	
 	

AGGRESSIVE EQUITY GROWTH FUND
	

 	
 	

By:	

/s/  THOMAS P. LARSEN      

	 	 	Name:	Thomas P. Larsen
	 	 	Title:	EVP Mutual of America Capital Mgt.

[Signature
Page to Securities Purchase Agreement of GTC Biotherapeutics, Inc.] 

	 	 	PURCHASER:
	

 	
 	

INSTITUTIONAL ALL AMERICAN SMALL CAP GROWTH FUND
	

 	
 	

By:	

/s/  THOMAS P. LARSEN      

	 	 	Name:	Thomas P. Larsen
	 	 	Title:	EVP Mutual of America Capital Mgt.

[Signature
Page to Securities Purchase Agreement of GTC Biotherapeutics, Inc.] 

	 	 	PURCHASER:
	

 	
 	

OMICRON MASTER TRUST
	

 	
 	

By:	

Omicron Capital L.P. as investment advisor
	 	 	By:	Omicron Capital Inc., its general partner
	

 	
 	

By:	

/s/  OLIVIER MORALI      

	 	 	Name:	Olivier Morali
	 	 	Title:	President
	

 	
 	

c/o Omicron Capital L.P.

810 Seventh Avenue, 39th Floor

New York, New York 10019

Attn: Brian Daly

[Signature
Page to Securities Purchase Agreement of GTC Biotherapeutics, Inc.] 

	 	 	PURCHASER:
	

 	
 	

PORTSIDE GROWTH AND OPPORTUNITY FUND
	

 	
 	

By:	

/s/  JEFF SMITH      

	 	 	Name:	Jeff Smith
	 	 	Title:	Director

[Signature
Page to Securities Purchase Agreement of GTC Biotherapeutics, Inc.] 

	 	 	PURCHASER:
	

 	
 	

ROYAL BANK OF CANADA
	 	 	By:	Its Agent RBC Dominion Securities Corporation
	

 	
 	

By:	

/s/  STEVEN MILKE      

	 	 	Name:	Steven Milke
	 	 	Title:	Managing Director
	

 	
 	

By:	

/s/  RICHARD TAVOSO      

	 	 	Name:	Richard Tavoso
	 	 	Title:	Managing Director

[Signature
Page to Securities Purchase Agreement of GTC Biotherapeutics, Inc.] 

	 	 	PURCHASER:
	

 	
 	

PANACEA FUND LLC
	

 	
 	

By:	

/s/  MICHAEL S. RESNICK      

	 	 	Name:	Michael S. Resnick
	 	 	Title:	Executive Vice President, William Harris Investors, Inc., as Manager

[Signature
Page to Securities Purchase Agreement of GTC Biotherapeutics, Inc.] 

 
 

Exhibit A  
    
    Schedule of Purchasers    
    

	Name, Address and Facsimile Number
 
	 	Residency
	 	Number of Shares
	 	Aggregate

Purchase Price

	BayStar Capital II, LP

c/o BayStar Capital Management, LLC

80 E. Sir Francis Drake Blvd., Suite 2B

Larkspur, CA 94939

415-834-4601	 	California	 	196,078	 	$	499,998.90
	

Castle Creek Healthcare Partners LLC

111 West Jackson Blvd., Suite 2020

Chicago, IL 60604

312-499-6999	
 	

Illinois	
 	

294,117	
 	
$	

749,998.35
	

Clarion Capital Corporation

1801 East Ninth St., Suite 510

Cleveland, OH 44114

216-694-3545	
 	

Ohio	
 	

100,000	
 	
$	

255,000.00
	

Deephaven Small Cap Growth Fund LLC

130 Cheshire Lane, Suite 102

Minnetonka, MN 55305

952-249-5320	
 	

Minnesota	
 	

392,157	
 	
$	

1,000,000.35
	

Gryphon Master Fund, LP

500 Crescent Ct. #270

Dallas, TX 75201

214-871-6909	
 	

Bermuda	
 	

196,078	
 	
$	

499,998.90
	

Capital Ventures International

c/o Heights Capital Management, Inc.

425 California St., Suite 1100

San Francisco, CA 94104

415-403-6525	
 	

California	
 	

588,235	
 	
$	

1,499,999.25
	

Smithfield Fiduciary LLC

c/o Highbridge Capital Management, LLC

9 West 57th Street, 27th Floor

New York, NY 10019

212-751-0755

Attention: Ari J. Storch / Adam J. Chill	
 	

Cayman Islands	
 	

196,078	
 	
$	

499,998.80
	

Midsummer Investment, Ltd.

c/o Midsummer Capital

485 Madison Avenue, 23rd Floor

New York, NY 10022

212-584-2142

Attention: Michael A. Amsalem	
 	

Bermuda	
 	

200,000	
 	
$	

510,000.00
	

All America — Small Cap Growth Fund

c/o Mutual of America Capital Management

320 Park Avenue

New York, NY 10022

212-224-2500	
 	

New York	
 	

95,372	
 	
$	

243,198.60
	 	 	 	 	 	 	 	 

	

Institutional Aggressive Equity Growth Fund

c/o Mutual of America Capital Management

320 Park Avenue

New York, NY 10022

212-224-2500	
 	

New York	
 	

10,863	
 	
$	

27,700.65
	

Aggressive Equity Growth Fund

c/o Mutual of America Capital Management

320 Park Avenue

New York, NY 10022

212-224-2500	
 	

New York	
 	

276,941	
 	
$	

706,199.55
	

Institutional All America Small Cap Growth Fund

c/o Mutual of America Capital Management

320 Park Avenue

New York, NY 10022

212-224-2500	
 	

New York	
 	

8,980	
 	
$	

22,899.99
	

Omicron Master Trust

c/o Omicron Capital, L.P.

810 Seventh Avenue, 39th Floor

New York, NY 10019

212-803-5269

Attn: Brian Daly	
 	

New York	
 	

137,254	
 	
$	

349,997.70
	

Portside Growth and Opportunity Fund

c/o Ramius Capital Group, LLC

666 Third Avenue, 26th Floor

New York, NY 10017

212-845-7995	
 	

New York	
 	

392,156	
 	
$	

999,997.80
	

Royal Bank of Canada

c/o RBC Dominion Securities Corp.

1 Liberty Plaza

165 Broadway

New York, NY 10006

212-858-7439

Attn: Steve Lin	
 	

Canada	
 	

392,156	
 	
$	

999,997.80
	

Panacea Fund LLC

c/o William Harris Investors, Inc.

2 North LaSalle St., Suite 400

Chicago, IL 60602

312-345-8002	
 	

Illinois	
 	

150,000	
 	
$	

382,500

 
 

Disclosure Schedule  
    

3(a): Subsidiaries 

ATIII
LLC

GTC Securities Corporation

TSI Corporation

Taurus hSA LLC

GTC Japan Limited

GTC Holding Ltd.

GTC NZ Limited 

QuickLinks

Exhibit 10.1 Execution Copy

GTC BIOTHERAPEUTICS, INC. SECURITIES PURCHASE AGREEMENT dated as of July 30, 2003

GTC BIOTHERAPEUTICS, INC. SECURITIES PURCHASE AGREEMENT

RECITALS

Exhibit A Schedule of Purchasers

Disclosure ScheduleQuickLinks
 -- Click here to rapidly navigate through this document

 
 

Exhibit 10.2    
    

NEITHER
THIS SECURITY NOR THE SECURITIES INTO WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE
UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE "SECURITIES ACT"), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION
STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE WITH APPLICABLE
STATE SECURITIES LAWS AS EVIDENCED BY A LEGAL OPINION OF COUNSEL TO THE TRANSFEROR TO SUCH EFFECT, THE SUBSTANCE OF WHICH SHALL BE REASONABLY ACCEPTABLE TO THE COMPANY. THESE SECURITIES AND THE
SECURITIES ISSUABLE UPON EXERCISE OF THESE SECURITIES MAY BE PLEDGED IN CONNECTION WITH A BONA FIDE MARGIN ACCOUNT SECURED BY SUCH SECURITIES. 

COMMON
STOCK PURCHASE WARRANT 

To
Purchase                        Shares of Common Stock of 

GTC
Biotherapeutics, Inc. 

        This
Common Stock Purchase Warrant (this "Warrant") certifies that, for value received,                        and any permitted
assignee (the "Holder"), is entitled, upon the terms and subject
to the limitations on exercise and the conditions hereinafter set forth, at any time on or after August 1, 2003 (the "Initial Exercise Date") and on or prior to the close of business on the
fifth anniversary of the Initial Exercise Date (the "Termination Date") but not thereafter, to subscribe for and purchase from GTC Biotherapeutics, Inc., a corporation incorporated in the
Commonwealth of Massachusetts (the "Company"), up to                        shares (the "Warrant Shares") of the Company's Common
Stock, par value $0.01 per share (the "Common Stock"). The purchase price of
one share of Common Stock (the "Exercise Price") under this Warrant shall be $3.30, subject to adjustment hereunder. The Exercise Price and the number of Warrant Shares for which the Warrant is
exercisable shall be subject to adjustment as provided herein. Capitalized terms used and not otherwise defined herein shall have the meanings set
forth in that certain Securities Purchase Agreement (the "Purchase Agreement"), dated as of July 30, 2003, between the Company and the purchasers signatory thereto. 

        1.    Title to Warrant.    Prior to the Termination Date and subject to compliance with
applicable laws and to the conditions set forth in Section 7(d) hereof and to the provisions of Section 2 of the Purchase Agreement, this Warrant and all rights hereunder are
transferable, in whole or in part, at the office or agency of the Company by the Holder in person or by duly authorized attorney, upon surrender of this Warrant together with the Assignment Form
annexed hereto properly endorsed. The transferee shall sign an investment letter in form and substance reasonably satisfactory to the Company. 

        2.    Authorization of Shares.    The Company covenants that all Warrant Shares which may
be issued upon the exercise of the purchase rights represented by this Warrant will, upon exercise of the purchase rights represented by this Warrant, be duly authorized, validly issued, fully paid
and nonassessable and free from all taxes, liens and charges in respect of the issue thereof (other than taxes in respect of any transfer occurring contemporaneously with such issue). 

        3.    Exercise of Warrant.    

        (a)   Except
as provided elsewhere herein, exercise of the purchase rights represented by this Warrant may be made at any time or times on or after the Initial Exercise Date
and on or before the Termination Date by the surrender of this Warrant and the Notice of Exercise Form annexed hereto duly executed, at the office of the Company (or such other office or agency of the
Company as it may designate by notice in writing to the registered Holder at the address of such Holder appearing on the books of the Company) and upon payment of the Exercise Price of the shares
thereby purchased by 

 

wire
transfer or cashier's check drawn on a United States bank or by means of a cashless exercise pursuant to Section 3(c), the Holder shall be entitled to receive a certificate for the number
of Warrant Shares so purchased. This Warrant shall be deemed to have been exercised and such certificate or certificates shall be deemed to have been issued, and Holder or any other person so
designated to be named therein shall be deemed to have become a holder of record of such shares for all purposes, as of the date the Warrant has been exercised by payment to the Company of the
Exercise Price and all taxes required to be paid by the Holder, if any, pursuant to Section 5 prior to the issuance of such shares, have been paid. 

        (b)   If
this Warrant shall have been exercised in part, the Company shall, at the time of delivery of the certificate or certificates representing Warrant Shares, deliver to
Holder a new Warrant evidencing the rights of Holder to purchase the unpurchased Warrant Shares called for by this Warrant, which new Warrant shall in all other respects be identical with this
Warrant. 

        (c)   If
after the Effectiveness Deadline (as such term is defined in the Registration Rights Agreement attached as an Exhibit to the Purchase Agreement (the
"Registration Rights Agreement")) (i) a Registration Statement has not been declared effective by the Commission registering the sale of the Warrant Shares to the
Holder (or alternatively, the resale of the Warrant Shares by the Holder), or (ii) after the date first declared effective by the Commission but prior to the expiration of the Registration
Period, as such term is defined in the Registration Rights Agreement, the Registration Statement ceases to be effective and available to register the sale of the Warrant Shares to the Holder (or
alternatively, the resale of the Warrant Shares by the Holder) for a total of Twenty Five (25) Trading Days in the aggregate, then until such Registration Statement has been declared effective
or for so long as it ceases to be available for more than a total of Twenty Five (25) Trading Days in the aggregate, as the case may be, this Warrant may also be exercised at such time by means
of a "cashless exercise" in which the Holder shall be entitled to receive a certificate for the number of Warrant Shares equal to the quotient obtained by dividing [(A-B)
(X)] by (A), where: 

(A)
– the VWAP on the trading day preceding the date of such election; 

(B)
– the Exercise Price of the Warrants, as adjusted; and 

(X)
– the number of Warrant Shares issuable upon exercise of the Warrants in accordance with the terms of this Warrant. 

For
purposes of this Warrant, "VWAP" means, for any date, the price determined by the first of the following clauses that applies: (a) if the Common Stock is then listed or quoted on the
American Stock Exchange, the New York Stock Exchange, the Nasdaq National Market or the Nasdaq SmallCap Market (each a "Principal Market"), the daily volume weighted average price of the Common Stock
for such date (or the nearest preceding date) on the Principal Market on which the Common Stock is then listed or quoted as reported by Bloomberg Financial L.P. (based on a trading day from
9:30 a.m. Eastern Time to 4:02 p.m. Eastern Time); (b) if the Common Stock is not then listed or quoted on a Principal Market and if prices for the Common Stock are then quoted on
the OTC Bulletin Board (or any successor market), the volume weighted average price of the Common Stock for such date (or the nearest preceding date) on the OTC Bulletin Board (or any successor
market); (c) if the Common Stock is not then listed or quoted on the OTC Bulletin Board (or any successor market) and if prices for the Common Stock are then reported in the "Pink Sheets"
published by the National Quotation Bureau Incorporated (or a similar organization or agency succeeding to its functions of reporting prices), the most recent bid price per share of the Common Stock
so reported; or (d) in all other cases, the fair market value of a share of Common Stock as determined by a nationally recognized-independent appraiser selected in good faith by the Company. 

        4.    No Fractional Shares or Scrip.    No fractional shares or scrip representing
fractional shares shall be issued upon the exercise of this Warrant. As to any fraction of a share which Holder would 

2

 

otherwise
be entitled to purchase upon such exercise, the Company shall pay a cash adjustment in respect of such final fraction in an amount equal to such fraction multiplied by the Exercise Price. 

        5.    Charges, Taxes and Expenses.    Issuance of certificates for Warrant Shares shall
be made without charge to the Holder for any issue or transfer tax or other incidental expense in respect of the issuance of such certificate, all of which taxes and expenses shall be paid by the
Company, and such certificates shall be issued in the name of the Holder or in such name or names as may be directed by the Holder; provided, however, that in the event certificates for Warrant Shares
are to be issued in a name other than the name of the Holder, this Warrant when surrendered for exercise shall be accompanied by the Assignment Form attached hereto duly executed by the Holder; and
the Company may require, as a condition thereto, the payment of a sum sufficient to reimburse it for any transfer tax incidental thereto. 

        6.    Closing of Books.    The Company will not close its stockholder books or records in
any manner which prevents the timely exercise of this Warrant, pursuant to the terms hereof. 

        7.    Transfer, Division and Combination.    

        (a)   Subject
to compliance with any applicable securities laws and the conditions set forth in Sections 1 and 7(d) hereof and to the provisions of Section 2 of the
Purchase Agreement, this Warrant and all rights hereunder are transferable, in whole or in part, upon surrender of this Warrant at the principal office of the Company, together with a written
assignment of this Warrant substantially in the form attached hereto duly executed by the Holder or its agent or attorney and funds sufficient to pay any transfer taxes payable upon the making of such
transfer. Upon such surrender and, if required, such payment, the Company shall execute and deliver a new Warrant or Warrants in the name of the assignee or assignees and in the denomination or
denominations specified in such instrument of assignment, and shall issue to the assignor a new Warrant evidencing the portion of this Warrant not so assigned, and this Warrant shall promptly be
cancelled. A Warrant, if properly assigned, may be exercised by a new holder for the purchase of Warrant Shares without having a new Warrant issued. 

        (b)   This
Warrant may be divided or combined with other Warrants upon presentation hereof at the aforesaid office of the Company, together with a written notice specifying
the names and denominations in which new Warrants are to be issued, signed by the Holder or its agent or attorney. Subject to compliance with Section 7(a), as to any transfer which may be
involved in such division or combination, the Company shall execute and deliver a new Warrant or Warrants in exchange for the Warrant or Warrants to be divided or combined in accordance with such
notice. 

        (c)   The
Company shall prepare, issue and deliver at its own expense (other than transfer taxes) the new Warrant or Warrants under this Section 7. 

        (d)   The
Company agrees to maintain, at its aforesaid office, books for the registration and the registration of transfer of the Warrants. 

        (e)   If,
at the time of the surrender of this Warrant in connection with any transfer of this Warrant, the transfer of this Warrant shall not be registered pursuant to an
effective registration statement under the Securities Act and under applicable state securities or blue sky laws, the Company may require, as a condition of allowing such transfer (i) that the
Holder or transferee of this Warrant, as the case may be, furnish to the Company a written opinion of counsel (which opinion shall be in form, substance and scope customary for opinions of counsel in
comparable transactions) to the effect that such transfer may be made without registration under the Securities Act and under applicable state securities or blue sky laws, (ii) that the Holder
or transferee execute and deliver to the Company an investment letter in form and substance acceptable to the Company and (iii) that the transferee be an "accredited investor" as defined in
Rule 501(a) promulgated under the Securities Act. 

3

 

        8.    No Rights as Shareholder until Exercise.    This Warrant does not entitle the
Holder to any voting rights or other rights as a shareholder of the Company prior to the exercise hereof. Upon the surrender of this Warrant and the payment of the aggregate Exercise Price (or if
permitted hereunder, by means of a cashless exercise), the Warrant Shares so purchased shall be and be deemed to be issued to such Holder as the record owner of such shares as of the close of business
on the later of the date of such surrender or payment. 

        9.    Loss, Theft, Destruction or Mutilation of Warrant.    The Company covenants that
upon receipt by the Company of evidence reasonably satisfactory to it of the loss, theft, destruction or mutilation of this Warrant or any stock certificate relating to the Warrant Shares, and in case
of loss, theft or destruction, of indemnity or security reasonably satisfactory to it (which, in the case of the Warrant, shall not include the posting of any bond), and upon surrender and
cancellation of such Warrant or stock certificate, if mutilated, the Company will make and deliver a new Warrant or stock certificate of like tenor and dated as of such cancellation, in lieu of such
Warrant or stock certificate. 

        10.    Saturdays, Sundays, Holidays, etc.    If the last or appointed day for the taking
of any action or the expiration of any right required or granted herein shall be a Saturday, Sunday or a legal holiday, then such action may be taken or such right may be exercised on the next
succeeding day not a Saturday, Sunday or legal holiday. 

        11.    Adjustments of Exercise Price and Number of Warrant Shares.    The number and kind
of securities purchasable upon the exercise of this Warrant and the Exercise Price shall be subject to adjustment from time to time upon the happening of any of the following. In case the Company
shall (i) pay a dividend in shares of Common Stock or make a distribution in shares of Common Stock to holders of its outstanding Common Stock, (ii) subdivide its outstanding shares of
Common Stock into a greater number of shares, (iii) combine its outstanding shares of Common Stock into a smaller number of shares of Common Stock, or (iv) issue any shares of its
capital stock in a reclassification of the Common Stock, then the number of Warrant Shares purchasable upon exercise of this Warrant immediately prior thereto shall be adjusted so that the Holder
shall be entitled to receive the kind and number of Warrant Shares or other securities of the Company which it would have owned or have been entitled to receive had such Warrant been exercised in
advance thereof. Upon each such adjustment of the kind and number of Warrant Shares or other securities of the Company which are purchasable hereunder, the Holder shall thereafter be entitled to
purchase the number of Warrant Shares or other securities resulting from such adjustment at an Exercise Price per Warrant Share or other security obtained by multiplying the Exercise Price in effect
immediately prior to such adjustment by the number of Warrant Shares purchasable pursuant hereto immediately prior to such adjustment, and dividing such product by the number of Warrant Shares or
other securities of the Company resulting from such adjustment. An adjustment made pursuant to this paragraph shall become effective immediately after the effective date of such event retroactive to
the record date, if any, for such event. 

        12.    Reorganization, Reclassification, Merger, Consolidation or Disposition of
Assets.    In case the Company shall reorganize its capital, reclassify its capital stock, consolidate or merge with or into another corporation (where the Company is not the
surviving corporation or where there is a change in or distribution with respect to the Common Stock of the Company), or sell, transfer or otherwise dispose of all or substantially all its property,
assets or business to another corporation and, pursuant to the terms of such reorganization, reclassification, merger, consolidation or disposition of assets, shares of common stock of the successor
or acquiring corporation, or any cash, shares of stock or other securities or property of any nature whatsoever (including warrants or other subscription or purchase rights) in addition to or in lieu
of common stock of the successor or acquiring corporation ("Other Property"), are to be received by or distributed to the holders of Common Stock of the Company, then the Holder shall have the right
thereafter to receive upon exercise of this Warrant, the number of shares of Common Stock of the successor or acquiring corporation or of the Company, if it is the surviving corporation, and Other
Property receivable upon or as a result of such reorganization, 

4

 

reclassification,
merger, consolidation or disposition of assets by a Holder of the number of shares of Common Stock for which this Warrant is exercisable immediately prior to such event. In case of
any such reorganization, reclassification, merger, consolidation or disposition of assets, the successor or acquiring corporation (if other than the Company) shall expressly assume the due and
punctual observance and performance of each and every covenant and condition of this Warrant to be performed and observed by the Company and all the obligations and liabilities hereunder, subject to
such modifications as may be deemed appropriate (as determined in good faith by resolution of the Board of Directors of the Company) in order to provide for adjustments of Warrant Shares for which
this Warrant is exercisable which shall be as nearly equivalent as practicable to the adjustments provided for in this Section 12. For purposes of this Section 12, "common stock of the
successor or acquiring corporation" shall include stock of such corporation of any class which is not preferred as to dividends or assets over any other class of stock of such corporation and which is
not subject to redemption and shall also include any evidences of indebtedness, shares of stock or other securities which are convertible into or exchangeable for any such stock, either immediately or
upon the arrival of a specified date or the happening of a specified event and any warrants or other rights to subscribe for or purchase any such stock. The foregoing provisions of this
Section 12 shall similarly apply to successive reorganizations, reclassifications, mergers, consolidations or disposition of assets. 

        13.    Limitation on Exercise.    Notwithstanding anything to the contrary contained
herein, the number of shares of Common Stock that may be acquired by the Holder upon any exercise of this Warrant (or otherwise in respect hereof) shall be limited to the extent necessary to insure
that, following such exercise (or other issuance), the total number of shares of Common Stock then beneficially owned by such Holder and its Affiliates and any other Persons whose beneficial ownership
of Common Stock would be aggregated with the Holder's for purposes of Section 13(d) of the Exchange Act, does not exceed 9.999% of the total number of issued and outstanding shares of Common
Stock (including for such purpose the shares of Common Stock issuable upon such exercise). For such purposes, beneficial ownership shall be determined in accordance with Section 13(d) of the
Exchange Act and the rules and regulations promulgated thereunder. Each delivery of an Exercise Notice hereunder will constitute a representation by the Holder that it has evaluated the limitation set
forth in this paragraph and determined that issuance of the full number of Warrant Shares requested in such Exercise Notice is permitted under this paragraph. This provision shall not restrict the
number of shares of Common Stock which a Holder may receive or beneficially own in order to determine the amount of securities or other consideration that such Holder may receive in the event of a
merger or other business
combination or reclassification involving the Company as contemplated in Section 12 of this Warrant. This restriction may not be waived without the consent of the Holder. 

        14.    Voluntary Adjustment by the Company.    The Company may at any time during the
term of this Warrant reduce the then current Exercise Price to any amount and for any period of time deemed appropriate by the Board of Directors of the Company. 

        15.    Notice of Adjustment.    Whenever the number of Warrant Shares or number or kind
of securities or other property purchasable upon the exercise of this Warrant or the Exercise Price is adjusted, as herein provided, the Company shall give notice thereof to the Holder, which notice
shall state the number of Warrant Shares (and other securities or property) purchasable upon the exercise of this Warrant and the Exercise Price of such Warrant Shares (and other securities or
property) after such adjustment, setting forth a brief statement of the facts requiring such adjustment and setting forth the computation by which such adjustment was made. 

        16.    Notice of Corporate Action.    If at any time: (a) the Company shall take a
record of the holders of its Common Stock for the purpose of entitling them to receive a dividend or other distribution, or any right to subscribe for or purchase any evidences of its indebtedness,
any shares of stock of any class or any other securities or property, or to receive any other right, or (b) there shall be any capital reorganization of the Company, any reclassification or
recapitalization of the capital stock 

5

 

of
the Company or any consolidation or merger of the Company with, or any sale, transfer or other disposition of all or substantially all the property, assets or business of the Company to, another
corporation or, (c) there shall be a voluntary or involuntary dissolution, liquidation or winding up of the Company; then, in any one or more of such cases, the Company shall give to Holder
(i) at least 20 days' prior written notice of the date on which a record date shall be selected for such dividend, distribution or right or for determining rights to vote in respect of
any such reorganization, reclassification, merger, consolidation, sale, transfer, disposition, liquidation or winding up, and (ii) in the case of any such reorganization, reclassification,
merger, consolidation, sale, transfer, disposition, dissolution, liquidation or winding up, at least 20 days' prior written notice of the date when the same shall take place. Such notice in
accordance with the foregoing clause also shall specify (i) the date on which any such record is to be taken for the purpose of such dividend, distribution or right, the date on which the
holders of Common Stock shall be entitled to any such dividend, distribution or right, and the amount and character thereof, and (ii) the date on which any such reorganization,
reclassification, merger, consolidation, sale, transfer, disposition, dissolution, liquidation or winding up is to take place and the time, if any such time is to be fixed, as of which the holders of
Common Stock shall be entitled to exchange their Warrant Shares for securities or other property deliverable upon such disposition, dissolution, liquidation or winding up. Each such written notice
shall be sufficiently given if addressed to Holder at the last address of Holder appearing on the books of the Company and delivered in accordance with Section 17(d). 

        17.    Authorized Shares.    The Company covenants that during the period the Warrant is
outstanding, it will reserve from its authorized and unissued Common Stock a sufficient number of shares to provide for the issuance of the Warrant Shares upon the exercise of any purchase rights
under this Warrant. The Company further covenants that its issuance of this Warrant shall constitute full authority to its officers who are charged with the duty of executing stock certificates to
execute and issue the necessary certificates for the Warrant Shares upon the exercise of the purchase rights under this Warrant. The Company will take all such reasonable action as may be necessary to
assure that such Warrant Shares may be issued as provided herein without violation of any applicable law or regulation, or of any requirements of the Principal Market upon which the Common Stock may
be listed at such time. 

        Except
and to the extent as waived or consented to by the Holder, the Company shall not by any action, including, without limitation, amending its articles of organization or through any
reorganization, transfer of assets, consolidation, merger, dissolution, issue or sale of securities or any other voluntary action, avoid or seek to avoid the observance or performance of any of the
terms of this Warrant, but will at all times in good faith assist in the carrying out of all such terms and in the taking of all such actions as may be necessary or appropriate to protect the rights
of Holder as set forth in this Warrant against impairment. Without limiting the generality of the foregoing, the Company will (a) not increase the par value of any Warrant Shares above the
amount payable therefor upon such exercise immediately prior to such increase in par value, (b) take all such action as may be necessary or appropriate in order that the Company may validly and
legally issue fully paid and nonassessable Warrant Shares upon the exercise of this Warrant, and (c) use commercially reasonable efforts to obtain all such authorizations, exemptions or
consents from any public regulatory body having jurisdiction thereof as may be necessary to enable the Company to perform its obligations under this Warrant. 

        Before
taking any action which would result in an adjustment in the number of Warrant Shares for which this Warrant is exercisable or in the Exercise Price, the Company shall obtain all
such authorizations or exemptions thereof, or consents thereto, as may be necessary from any public regulatory body or bodies having jurisdiction thereof. 

6

 

        18.    Miscellaneous.    

        (a)    Jurisdiction.    All questions concerning the construction, validity, enforcement
and interpretation of this Warrant shall be governed by the internal laws of the State of New York, without giving effect to any choice of law or conflict of law provision or rule (whether of the
State of New York or any other jurisdictions) that would cause the application of the laws of any jurisdictions other than the State of New York. Each party hereby irrevocably submits to the
non-exclusive jurisdiction of the state and federal courts sitting in the City of New York, Borough of Manhattan, for the adjudication of any dispute hereunder or in connection herewith or
with any transaction contemplated hereby or discussed herein, and hereby irrevocably waives, and agrees not to assert in any suit, action or proceeding, any claim that it is not personally subject to
the jurisdiction of any such court, that such suit, action or proceeding is brought in an inconvenient forum or that the venue of such suit, action or
proceeding is improper. Each party hereby irrevocably waives personal service of process and consents to process being served in any such suit, action or proceeding by mailing a copy thereof to such
party at the address for such notices to it under this Warrant and agrees that such service shall constitute good and sufficient service of process and notice thereof. EACH PARTY HEREBY IRREVOCABLY
WAIVES ANY RIGHT IT MAY HAVE, AND AGREES NOT TO REQUEST, A JURY TRIAL FOR THE ADJUDICATION OF ANY DISPUTE HEREUNDER OR IN CONNECTION HEREWITH OR ARISING OUT OF THIS WARRANT OR ANY TRANSACTION
CONTEMPLATED HEREBY. 

        (b)    Restrictions.    The Holder acknowledges that the Warrant Shares acquired upon the
exercise of this Warrant, if not registered, will have restrictions upon resale imposed by state and federal securities laws. 

        (c)    Nonwaiver.    No course of dealing or any delay or failure to exercise any right
hereunder on the part of Holder shall operate as a waiver of such right or otherwise prejudice Holder's rights, powers or remedies, notwithstanding all rights hereunder terminate on the Termination
Date. 

        (d)    Notices.    Any notice, request or other document required or permitted to be
given or delivered to the Holder by the Company shall be delivered in accordance with the notice provisions of the Purchase Agreement. 

        (e)    Limitation of Liability.    No provision hereof, in the absence of any affirmative
action by Holder to exercise this Warrant or purchase Warrant Shares, and no enumeration herein of the rights or privileges of Holder, shall give rise to any liability of Holder for the purchase price
of any Common Stock or as a stockholder of the Company, whether such liability is asserted by the Company or by creditors of the Company. 

        (f)    Remedies.    Holder, in addition to being entitled to exercise all rights granted
by law, including recovery of damages, will be entitled to specific performance of its rights under this Warrant. The Company agrees that monetary damages would not be adequate compensation for any
loss incurred by reason of a breach by it of the provisions of this Warrant and hereby agrees to waive the defense in any action for specific performance that a remedy at law would be adequate. 

        (g)    Successors and Assigns.    Subject to applicable securities laws, this Warrant and
the rights and obligations evidenced hereby shall inure to the benefit of and be binding upon the successors of the Company and the successors and permitted assigns of Holder. The provisions of this
Warrant are intended to be for the benefit of all Holders from time to time of this Warrant and shall be enforceable by any such Holder or holder of Warrant Shares. 

        (h)    Amendment.    Except as provided in Section 13, this Warrant may be
modified or amended or the provisions hereof waived with the written consent of the Company and the holders of Warrants issued under the Purchase Agreement representing a majority of the Warrant
Shares issuable under Warrants then outstanding as of the date such consent is sought. 

        (i)    Severability.    Wherever possible, each provision of this Warrant shall be
interpreted in such manner as to be effective and valid under applicable law, but if any provision of this Warrant shall be prohibited by or invalid under applicable law, such provision shall be
ineffective to the extent of such prohibition or invalidity, without invalidating the remainder of such provisions or the remaining provisions of this Warrant. 

        (j)    Headings.    The headings used in this Warrant are for the convenience of
reference only and shall not, for any purpose, be deemed a part of this Warrant. 

        (k)    Acceptance.    Receipt of this Warrant by the Holder shall constitute acceptance
of and agreement to all of the terms and conditions contained herein. 

[Remainder
of page intentionally left blank.] 

7

        IN WITNESS WHEREOF, the Company has caused this Warrant to be executed by its officer thereunto duly authorized. 

Dated:
August 1, 2003 

	 	 	GTC BIOTHERAPEUTICS, INC.
	

 	
 	

By:	
 	

 John B. Green

Senior Vice President, Chief Financial Officer and Treasurer

 
 

NOTICE OF EXERCISE    
    

To:
GTC Biotherapeutics, Inc. 

        (1)   The
undersigned hereby elects to purchase                        Warrant Shares of GTC Biotherapeutics, Inc. pursuant to the
terms of the attached Warrant, and tenders
herewith payment of the exercise price of such Warrant Shares in full, together with all applicable transfer taxes, if any. 

        (2)   Payment
shall take the form of (check applicable box): 

	o
	lawful
money of the United States; or

	o
	the
cancellation of such number of Warrant Shares as is necessary, in accordance with the formula set forth in subsection 3(c), to exercise
this Warrant with respect to the maximum number of Warrant Shares purchasable pursuant to the cashless exercise procedure set forth in subsection 3(c). 

        (3)   Please
issue a certificate or certificates representing said Warrant Shares in the name of the undersigned or in such other name as is specified below: 

	

 	
 	

	
 	

 

The
Warrant Shares shall be delivered to the following: 

	

 	
 	

	
 	

 
	

 	
 	

	
 	

 
	

 	
 	

	
 	

 

        (4)    Accredited Investor.    The undersigned is an "accredited investor" as defined in
Regulation D promulgated under the Securities Act of 1933, as amended. 

	 	 	[PURCHASER]
	

 	
 	

By:	
 	

	 	 	Name:

Title:	 	 
	

 	
 	

Dated:	
 	

 
 

ASSIGNMENT FORM    
    
    for    
    
    Common Stock Purchase Warrant
  of GTC Biotherapeutics, Inc.    
    
    (To assign the foregoing Warrant, execute
  this form and supply required
information.
  Do not use this form to exercise the warrant.)    
    

        FOR VALUE RECEIVED, the foregoing Warrant and all rights evidenced thereby are hereby assigned to 

	

	
 	

whose address is
	

	

	

 	
 	

Dated:	
 	

	

Holder's Signature:	
 	

	

Holder's Address:	
 	

	

 	
 	

	

Signature Guaranteed:	
 	

	
 	

 

        NOTE:
The signature to this Assignment Form must correspond with the name as it appears on the face of the Warrant, without alteration or enlargement or any change whatsoever, and must
be guaranteed by a bank or trust company. Officers of corporations and those acting in a fiduciary or other representative capacity should file proper evidence of authority to assign the foregoing
Warrant. 

QuickLinks

Exhibit 10.2

NOTICE OF EXERCISE

ASSIGNMENT FORM for Common Stock Purchase Warrant of GTC Biotherapeutics, Inc. (To assign the foregoing Warrant, execute this form and supply required information. Do not use this form to exercise the
warrant.)

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