Document:

EX-10.14

 Exhibit 10.14 

XCHANGE AT BEDFORD 
 LEASE 

between 
 DIV BEDFORD,
LLC, as Landlord 
 and 

KALEIDO BIOSCIENCES, INC., as Tenant 

18 Crosby Drive 
 Bedford,
Massachusetts 
 As of May 15, 2017 
  

 TABLE OF CONTENTS 

 

							
	 ARTICLE 1
	  	GRANT	  	 	1	 
			
	 ARTICLE 2
	  	TERM	  	 	3	 
			
	 ARTICLE 3
	  	COMPLETION AND OCCUPANCY OF THE PREMISES	  	 	3	 
			
	 ARTICLE 4
	  	RENT AND SECURITY	  	 	4	 
			
	 ARTICLE 5
	  	ADDITIONAL RENT FOR ESCALATIONS IN REAL ESTATE TAXES AND OPERATING EXPENSES	  	 	6	 
			
	 ARTICLE 6
	  	SERVICES AND UTILITIES	  	 	11	 
			
	 ARTICLE 7
	  	CONDUCT OF BUSINESS BY TENANT	  	 	14	 
			
	 ARTICLE 8
	  	ALTERATIONS, IMPROVEMENTS AND SIGNAGE	  	 	21	 
			
	 ARTICLE 9
	  	INSURANCE	  	 	25	 
			
	 ARTICLE 10
	  	CASUALTY	  	 	27	 
			
	 ARTICLE 11
	  	CONDEMNATION	  	 	28	 
			
	 ARTICLE 12
	  	ASSIGNMENT AND SUBLETTING	  	 	29	 
			
	 ARTICLE 13
	  	DEFAULTS AND REMEDIES	  	 	32	 
			
	 ARTICLE 14
	  	SUBORDINATION; ATTORNMENT AND RIGHTS OF MORTGAGE HOLDERS	  	 	36	 
			
	 ARTICLE 15
	  	NOTICES	  	 	37	 
			
	 ARTICLE 16
	  	MISCELLANEOUS	  	 	37	 

 List of Exhibits 
  

			
	Exhibit 1.1-1	  	Premises
	Exhibit 1.1-2	  	Legal Description
	Exhibit 1.3	  	Plan
	Exhibit 6.1	  	Cleaning Specifications
	Exhibit 7.4	  	Rules and Regulations
	Exhibit 7.6.1.1	  	Environmental Questionnaire
	Exhibit 8.5	  	Certain Surrender Obligations
	Exhibit 14.1	  	Form of SNDA
	Exhibit 14.4	  	Form of Estoppel

 LEASE 

This Lease is made and entered into as of May 15, 2017 by and between DIV BEDFORD, LLC, a Massachusetts limited liability company with
its principal place of business at c/o The Davis Companies, 125 High Street, 21st Floor, Boston, Massachusetts 02110 (the “Landlord”) and KALEIDO BIOSCIENCES, INC., a Delaware
corporation with its principal place of business at 18 Crosby Drive, Bedford, Massachusetts (the “Tenant”). 
 
ARTICLE 1    GRANT 
 1.1    Premises. Landlord, for and in consideration of
the rents herein reserved and of the covenants and agreements herein contained on the part of Tenant to be performed, hereby leases to Tenant and Tenant accepts from Landlord, the entire first and second floors of the office building known as 18
Crosby Drive, Bedford, Massachusetts (the “Building”), containing approximately 50,000 rentable square feet in area as shown on Exhibit 1.1-1 attached hereto and made a part hereof (the
“Premises”). The Premises shall specifically include the loading docks and other loading facilities that are part of or appurtenant to the Building, so long as Tenant is leasing the entire Premises originally leased by Tenant
hereunder. The Premises, the Building, the “Common Areas” (defined below) and the land upon which the same are located, which is legally described in Exhibit 1.1-2 (the
“Land”), together with all other buildings and improvements thereon and thereunder are collectively referred to as the “Property”. The Property is also known as Xchange at Bedford and currently has an address of 4-18 Crosby Drive, as shown on Exhibit 1.3, attached. The parties agree that the rentable square footage of the Premises set forth above is conclusive and binding, subject to adjustment only in connection
with the expansion of the Premises or as set forth in this Lease. 
 1.2    Common Areas. Landlord hereby
grants to Tenant during the term of this Lease, a right to use, in common with the others entitled to such use, the Common Areas as they from time to time exist, subject to the rights, powers and privileges herein reserved to Landlord. The term
“Common Areas” as used herein will include all areas and facilities outside the Premises that are provided and designated by Landlord for general non-exclusive use and convenience of Tenant and other
tenants at the Property. Common Areas include but are not limited to the fitness center, cafeteria, common hallways, lobbies, stairways and elevators, if any, pedestrian sidewalks, landscaped areas, loading areas, roadways, parking areas, rights of
way, walking and jogging paths, if any. Landlord may designate certain Common Areas for the exclusive use of one or more buildings located on the Property. Landlord acknowledges that the Common Areas located within the Building will not serve any
other tenants in buildings at the Property so long as Tenant is leasing the entire Premises originally leased by Tenant hereunder. 

1.3    Parking. During the Term of this Lease, Tenant shall be entitled to use, at no additional charge
(other than to the extent included in Operating Expenses and Taxes), the parking areas at the Property shown on Exhibit 1.3 attached hereto (the “Parking Areas”) in common with other tenants of the Property, but in any event
Tenant’s use shall not exceed the ratio of 3.0 spaces per 1,000 rentable square feet of the Premises (up to 150 spaces) on an unreserved, first-come, first-serve basis, except that Tenant shall have the exclusive right to use the area
designated as “Tenant’s Visitor Parking Area” on Exhibit 1.3, attached, for parking by Tenant and its visitors. Landlord, at Tenant’s sole cost and expense, will, by the use of signs and markings, designate the spaces
within such area as being intended for the use of Tenant’s visitors, but shall not be obligated to police the use of such spaces, which Tenant recognizes are to be operated on a self-parking basis. The Parking Areas shall be available for use
twenty-four (24) hours a day, every day of the year during the Term, subject to Force Majeure, casualty, and condemnation, and shall be illuminated when necessary. Further, Landlord shall keep and maintain the Parking Areas in a good and clean
condition. Tenant agrees not to overburden the Parking Areas and agrees to cooperate with Landlord and other tenants in the use of the Parking Areas. Subject to Tenant’s rights set forth herein, Landlord may designate parking facilities at the
Property for the handicapped, visitors to the Property, and for exclusive use by other tenants. Landlord may install signage or implement a pass or sticker system to control parking use, and may employ valet parking (including by use of off-site premises) to meet the requirements of this Section. To the extent applicable to Tenant’s use of the parking spaces, the provisions of this Lease shall apply, and Landlord may promulgate rules and
regulations of general applicability from time to time with respect to such use. Landlord assumes no responsibility whatsoever for loss or damage due to fire, theft or otherwise to any automobile(s) parked in

  
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the Parking Areas or to any personal property therein, however caused, and Tenant agrees, upon request from Landlord from time to time, to notify its officers, employees, agents and invitees of
such limitation of liability. 
 1.4    Generator and Carbon Dioxide Tank. Subject to the provisions of
this Section 1.4, Tenant shall have the right to install, maintain, repair, replace and use, at no additional charge, a generator, related connections and a diesel fuel tank or similar fuel storage compartment (collectively, the
“Generator”) and a liquid carbon dioxide storage tank of a size and capacity reasonably approved by Landlord (the “CO2 Tank”), each in an area on the Property to be mutually agreed upon by Landlord and Tenant (it
being understood and agreed that the Generator may not be installed on the roof of the Building). 
 Tenant’s use of the Generator and
CO2 Tank (collectively, the “Tenant’s Equipment”) shall be upon all of the conditions of the Lease, except as modified below: 

(i)    Tenant shall be responsible, at its sole cost and expense, for installing the Tenant’s Equipment. In addition
to complying with Section 8.3, below, Tenant shall not install or operate any portion of the Tenant’s Equipment until Tenant shall have obtained Landlord’s prior written approval of Tenant’s plans and
specifications therefor, which approval shall not be unreasonably withheld or delayed. Landlord will inform Tenant in writing at the time of its review and approval of such plans and specifications whether Landlord will require the same to be
removed by Tenant up on the expiration or earlier termination of the Lease. 
 (ii)    Landlord shall have no obligation
to provide any services to the Tenant’s Equipment, provided Tenant shall have the right to connect Tenant’s Equipment to existing base building utility systems, subject to Landlord’s right to reasonably approve such connections.
Tenant shall, at its sole cost and expense and otherwise in accordance with the provisions of this Section 1.4, arrange for all utility services required for the operation of the Tenant’s Equipment. 

(iii)    Tenant shall have no right to make any changes, alterations or other improvements to the Tenant’s Equipment
without Landlord’s prior written consent, which consent shall not be unreasonably withheld or delayed; provided, however, that Tenant shall have the right to maintain and make repairs to the Tenant’s Equipment. 

(iv)    Subject to Section 9.6.1, Tenant shall be responsible for the cost of repairing any damage to the
Building, Property or the office park caused by the installation, use and removal of the Tenant’s Equipment. 

(v)    Except for assignees of Tenant or subtenants of all or a portion of the Premises, no other person, firm or entity
(including without limitation, other tenants, licensees or occupants of the office park) shall have the right to connect to the Tenant’s Equipment other than Tenant. 

(vi)    To the maximum extent permitted by law, Tenant’s use of the Tenant’s Equipment shall be at the sole risk
of Tenant, and Landlord shall have no liability to Tenant in the event that the Tenant’s Equipment is damaged for any reason. 

(vii)    In addition to the indemnification obligations of Tenant set forth in this Lease including those contained in
Section 9.4(a), below, Tenant shall, to the maximum extent permitted by law and except to the extent arising from the negligence or willful misconduct of Landlord or any Landlord Parties (as defined below), indemnify,
defend and hold Landlord and the Landlord Parties harmless from any and all claims, losses, demands, actions or causes of actions suffered by any person, firm, corporation or other entity arising from the installation, use or removal of the
Tenant’s Equipment. 
 Tenant shall, at its sole cost and expense, secure the approvals of all governmental authorities and all permits
required by governmental authorities having jurisdiction over such approvals for the Tenant’s Equipment, and shall provide Landlord with copies of such approvals and permits prior to commencing any work with respect thereto. In addition, Tenant
shall be solely responsible for all costs and expenses in connection with the installation, maintenance, use and removal of the Tenant’s Equipment, except that Tenant will not be obligated to pay Landlord any additional rental for that portion
of the Property upon which Tenant’s Equipment is located. In connection therewith, Tenant shall provide Landlord with evidence on an annual basis of the existence of a maintenance contract for the Generator

  
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with a service provider reasonably acceptable to Landlord. Tenant shall have access to those portions of the Building and the Property on which the Tenant’s Equipment is located for the
purposes of inspecting, repairing, maintaining and replacing the same, subject in all events to Landlord’s reasonable rules and regulations regarding such access (it being understood and agreed, without limiting the generality of the foregoing,
that access to the rooftops of the Building is controlled by Landlord). 
 ARTICLE 2    TERM 

2.1    Lease Term. 

2.1.1    Commencement Date; Term. Tenant currently occupies a substantial portion of the Premises.
The Premises shall be leased to Tenant pursuant to this Lease for a term (the “Term”) to commence on May 15, 2017 (the “Commencement Date). The Term shall end on June 30, 2020 (the “Expiration
Date”), unless sooner terminated as herein provided. On or prior to the Commencement Date, Landlord shall deliver to Tenant exclusive possession of that portion of the Premises that Tenant does not currently occupy in the in broom-clean
condition, free of all furniture, equipment and other personal property, but otherwise in “as is” condition. 

2.1.2    Lease Year Defined. The first “Lease Year” shall begin on the Commencement
Date and shall end on the last day of the twelfth (12th) full calendar month following the Commencement Date. Each Lease Year thereafter shall consist of twelve (12) consecutive calendar months following the end of the immediately preceding
Lease Year. 
 2.1.3    Early Vacancy of the Premises. If (A) Tenant delivers a notice to
Landlord (an “Early Vacancy Notice”) on or following the date that is two years after the Commencement Date and such Early Vacancy Notice specifies a date (the “Early Vacancy Date”) prior to the Expiration Date that
Tenant intends to vacate the entire Premises, and (B) thereafter, (i) Landlord enters into one or more leases of the entire Premises with one or more third parties for a term commencing on or after the Early Vacancy Date and prior to the
scheduled Expiration Date (any such lease or leases being satisfactory to Landlord in its sole and absolute discretion), (ii) Tenant contemporaneously enters into an early termination agreement satisfactory to Landlord in its sole and absolute
discretion (which agreement, among other things, shall not provide for any early termination payment or fee to Tenant), and (iii) Tenant surrenders the Premises in the condition required by this Lease on the date set forth in the early
termination agreement, then Landlord shall treat such date as the Expiration Date for all purposes under this Lease. Nothing in the immediately preceding sentence shall be deemed to obligate Landlord to enter into any such leases described in clause
(i), above, the early termination agreement described in clause (ii), above, or shall otherwise create any claim against, or liability of, Landlord arising out of this paragraph, including any claims that Landlord is in default under this Lease. The
provisions of this paragraph shall be of no force and effect following any Event of Default. 
 2.2    Holding
Over. In the event that Tenant retains occupancy of the Premises, or any part thereof, after the end of the Term, Tenant’s occupancy of the Premises shall be as a tenant at will terminable at any time by Landlord. Tenant shall pay
Landlord rent for such time as Tenant remains in possession of the Premises at the rate equal to the higher of (a) two hundred percent (200%) of the Base Rent payable during the last month of the Term, or (b) one hundred twenty-five
percent (125%) of the then market-rate for the Premises, plus all Additional Rent and other sums due under this Lease. In addition, if Tenant’s holdover continues for more than thirty (30) days, Tenant shall pay Landlord for all damages
sustained by reason of Tenant’s retention of possession of the Premises after the end of the Term. The provisions hereof do not limit or restrict Landlord’s rights or remedies under this Lease in the event of any holding over by Tenant.

 ARTICLE 3    COMPLETION AND OCCUPANCY OF THE PREMISES 

3.1    Condition of the Premises. Tenant acknowledges that it is currently in possession of a substantial
portion of the Premises. Tenant acknowledges that, except as expressly set forth in this Lease, neither Landlord nor any agent of Landlord has made any representation or warranty with respect to the condition of the Premises, the Building or the
Property, or with respect to the suitability of the Premises, the Building or the Property for the conduct of Tenant’s business. Tenant acknowledges that (a) it is fully familiar with the condition of the Premises and agrees to take the
same in its condition “as is” 

  
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as of the Commencement Date and (b) Landlord shall have no obligation to alter, repair or otherwise prepare the Premises for Tenant’s occupancy or to pay for or construct any
improvements to the Premises, except as otherwise expressly provided herein. Tenant’s execution of this Lease and taking of possession of the entire Premises shall conclusively establish that the Premises, the Building and the Property were at
such time in satisfactory condition and repair. 
 ARTICLE 4    RENT AND SECURITY

 4.1    Base Rent. 

4.1.1    Schedule of Monthly Rent Payments. Beginning with the Commencement Date and continuing
throughout the Term, Tenant shall pay to or upon the order of Landlord an annual rental (the “Base Rent”) as set forth below which shall be payable in consecutive monthly installments on or before the first day of each calendar
month in advance in the monthly amount set forth below: 
  

							
	 Period
	  	Annual Base Rent	  	Monthly Base Rent	  	Annual Base Rent
per Rentable Square Foot
	 Commencement
	  	$917,500.00	  	$76,458.33	  	$18.35
	 Date - 12/31/19
	  		  		  	
	 1/1/20 - 6/30/20
	  	$967,500.00	  	$80,625.00	  	$19.35

 4.1.2    Manner of Payment. All payments of rent shall be made without demand,
deduction, counterclaim, set-off, discount or abatement (except as otherwise expressly set forth in this Lease) in lawful money of the United States of America. If the Commencement Date should occur on a day
other than the first day of a calendar month, or the Expiration Date should occur on a day other than the last day of a calendar month, then the monthly installment of Base Rent for such fractional month shall be prorated upon a daily basis based
upon a thirty (30)-day paid month. 
 4.2    Additional Rent.
Tenant shall pay to Landlord all charges and other amounts required under this Lease and the same shall constitute additional rent hereunder (herein called “Additional Rent”), including, without limitation, any sums due resulting
from the provisions of Article 5 hereof. All such amounts and charges shall be payable to Landlord in accordance with Section 4.3 hereof. Landlord shall have the same remedies for a default in the payment of
Additional Rent as for a default in the payment of Base Rent. The term “Rent” as used in this Lease shall mean the Base Rent and the Additional Rent. 

4.3    Place of Payment. The Base Rent and all other sums payable to Landlord under this Lease shall be paid
to Landlord at c/o The Davis Companies, 125 High Street, 21st Floor, Boston, MA 02110, or at such other place as Landlord shall designate in writing by at least thirty (30) days’ prior
notice to Tenant from time to time. 
 4.4    Terms of Payment. Tenant shall pay to Landlord all Base Rent
as provided in Section 4.1 above and Tenant shall pay all Additional Rent payable under Article 5 and Article 6 on the terms provided therein. Except as provided in the immediately preceding sentence and as may otherwise be
expressly provided by the terms of this Lease, Tenant shall pay to Landlord, within thirty (30) days after delivery by Landlord to Tenant of bills or statements therefor all sums of money payable by Tenant to Landlord in accordance with the
terms of this Lease. 
 4.5    Late Charges. If Tenant shall fail to pay any Rent within five
(5) days after the date same is due and payable or if any check received by Landlord from Tenant shall be dishonored, Tenant agrees that Landlord’s actual damages resulting therefrom are difficult to fix or ascertain. As a result, Tenant
shall pay to Landlord (a) an administrative fee equal to five percent (5%) per month on the amount due, and (b) interest on the amount due from its due date until paid at the lesser of eighteen percent (18%) per annum or the maximum legal
rate that Landlord may charge Tenant. Such charges shall be paid to Landlord together with such unpaid amounts as an administrative fee to compensate Landlord for administrative expenses and its cost of funds. 

  
 4 

 4.6    Security Deposit. 

4.6.1    Letter of Credit Amount. On or before July 24, 2017, Tenant shall deliver to Landlord
a security deposit (the “Security Deposit”) in the form of a “Letter of Credit” (as defined below) in the amount of $117,156.33 for the faithful performance of all terms, covenants and conditions of this Lease.
Tenant agrees that its failure to deliver the Security Deposit to Landlord as required in the preceding sentence following notice from Landlord and Tenant’s failure to cure within three (3) business days after such notice, shall, at
Landlord’s election, be a default under this Lease for which there shall be no further cure. 

4.6.2.    Letter of Credit Requirements. Each letter of credit provided to Landlord hereunder as the
Security Deposit shall be in the form of an unconditional, irrevocable, standby letter of credit which shall be in full force and effect for the periods required hereby, and shall meet all of the following conditions (a “Letter of
Credit”): 
 (a)    it shall be issued for the benefit of Landlord by an “Eligible
Bank” (defined below) approved by Landlord, which approval shall not be unreasonably withheld, delayed or conditioned; 

(b)    it shall be effective on the date of this Lease and have a term of not less than one (1) year
following its date of issuance and contain automatic year-to-year renewal provisions subject to the Letter of Credit issuer’s obligation to notify Landlord in
writing by certified or registered mail of non-renewal at least thirty (30) days prior to the expiration of the Letter of Credit; 

(c)    the expiration date of the Letter of Credit for the final Lease Year of the Term shall be at least
sixty (60) days following the Expiration Date of this Lease; 
 (d)    it shall provide for the
amount thereof as set forth in Subsection 4.6.1 to be available to Landlord in multiple drawings conditioned only upon presentation of a sight draft; 

(e)    it shall be assignable by Landlord to its successors, assigns and mortgagees and by any successive
beneficiaries thereof at no cost to transferor or transferee (Tenant agreeing to pay such charges in connection with any transfer of the Letter of Credit), and shall expressly permit multiple assignments; and 

(f)    it shall be in such form as shall be acceptable to Landlord in its reasonable discretion. 

An “Eligible Bank” shall mean a commercial or savings bank organized under the laws of the United States or
any state thereof or the District of Columbia and having total assets in excess of $1,000,000,000.00 which shall be a financial institution having a rating of not less than BBB or its equivalent by Standard and Poors Corporation and subject to a
Thompson Watch Rating of C or better. Landlord hereby acknowledges that Pacific Western Bank or Square One Bank is an Eligible Bank as of the date hereof. Tenant, at its expense, shall cause the issuing bank to provide Landlord’s mortgage
lender with a written acknowledgment which evidences its consent to Landlord’s collateral assignment of the proceeds of the Letter of Credit and acknowledgment of the security interest of such mortgage lender therein within ten
(10) business days following the request of Landlord or Landlord’s mortgagee therefor. 

4.6.3    Substitute Letter of Credit. Tenant shall deliver to Landlord a substitute Letter of Credit
that satisfies the requirements for a Letter of Credit stated in this Subsection 4.6.2 for the applicable period not later than ten (10) days following delivery of a non-renewal notice by the
Letter of Credit issuer with respect to the Letter of Credit issued to Landlord or thirty (30) days prior to the scheduled expiration of the Letter of Credit, whichever first occurs (such date, the “Re-Delivery Deadline”). If
Tenant fails to deliver the substitute Letter of Credit within such ten (10) day period or such thirty (30) period, as applicable, Landlord shall have the right to draw the Letter of Credit and receive the proceeds as a cash Security
Deposit. Tenant agrees that, 

  
 5 

 
notwithstanding any provision of this Lease to the contrary, its failure to furnish Landlord with the required Security Deposit in the form of a substitute Letter of Credit in compliance with the
requirements for the initial Letter of Credit prior to the Re-Delivery Deadline shall not be subject to any rights of notice or cure under this Lease. 

4.6.4    Landlord’s Rights Upon Default. Upon the occurrence of any of the Events of Default
described in Article 13 hereof, in addition to any other rights or remedies available to Landlord under this Lease, Landlord shall have the right to present the Letter of Credit for payment by the issuing bank and the proceeds thereof shall
be due and payable to Landlord in accordance with the terms hereof and the Letter of Credit. Tenant agrees that Landlord may, without waiving any of Landlord’s other rights and remedies under this Lease upon the occurrence of any of the Events
of Default, apply the Security Deposit to remedy any failure by Tenant to perform any of the terms, covenants or conditions to be performed by Tenant under this Lease and to compensate Landlord for any damages incurred as a result of any such Event
of Default. If Landlord uses any portion of the Security Deposit to cure any Event of Default by Tenant hereunder, Tenant shall forthwith replenish the Security Deposit to the original amount within ten (10) days following written notice from
Landlord in the manner directed by Landlord in such notice (which may be in the form of a new or amended Letter of Credit, or in the form of a cash payment). If Tenant fails to restore the full amount of the Security Deposit within such 10 day
period, then the amount of such deficiency shall be subject to the charges described in Section 4.5. During any period that Landlord is holding the Security Deposit in the form of cash, Landlord shall not be required to
keep the Security Deposit separate from its general funds, and Tenant shall not be entitled to interest on any such deposit. 

4.6.5    Sale of Building. In the event of a sale or other transfer of the Building (or
Landlord’s interest therein), Landlord shall transfer the balance of the Security Deposit or credit the same to the new owner or transferee. Upon any such transfer and the written agreement by the successor landlord that it has received the
Security Deposit and that it has assumed all of Landlord’s obligations under this Lease, Landlord shall thereupon be released by Tenant from all liability for the return of the Security Deposit; and, thereafter, Tenant shall look to the new
landlord for the return of such Security Deposit. If no notice of an Event of Default is outstanding for which a cure has not been completed at the end of the Term, Landlord shall, within sixty (60) days after the expiration or earlier
termination of the Lease, return the Security Deposit, or so much as has not been applied by Landlord as provided herein, to Tenant. 

4.7    Independence of Covenants. Landlord’s and Tenant’s covenants herein are independent and,
without limiting the generality of the foregoing, Tenant acknowledges that its covenant to pay Rent hereunder is independent of Landlord’s obligations hereunder, and that, in the event that Tenant shall have a claim against Landlord, Tenant
shall not have the right to deduct the amount allegedly owed to Tenant from any Rent due hereunder, it being understood that Tenant’s sole remedy for recovering upon such claim shall be to bring an independent legal action against Landlord. As
such, Tenant’s obligation so to pay Rent under the Lease shall be absolute, unconditional, and independent and shall not be discharged or otherwise affected by any law or regulation now or hereafter applicable to the Premises, or any other
restriction on Tenant’s use, or, except as otherwise expressly provided in the Lease, any casualty or taking, or any failure by Landlord to perform or other occurrence, and Tenant waives all rights now or hereafter existing to terminate, quit
or surrender this Lease or the Premises or any part thereof, or to assert any defense in the nature of constructive eviction to any action seeking to recover Rent, except as otherwise expressly provided in this Lease. Nothing in this paragraph shall
be deemed to prevent Tenant from the benefit of its express remedy under Section 6.1 of this Lease or the benefit of the provisions applicable following casualty and condemnation pursuant to Articles 10 and 11 of this
Lease, in each case on the terms set forth therein. 
 ARTICLE 5    ADDITIONAL RENT
FOR REAL ESTATE TAXES AND OPERATING EXPENSES 
 5.1    Definitions. Tenant agrees to pay as Additional
Rent, an amount calculated as hereinafter set forth. For purposes of this Article 5, the following definitions shall apply: 

“Tax Year”. The fiscal year of the Town of Bedford (July 1 – June 30) or other applicable governmental
authority for real estate tax purposes or such other twelve (12)-month period as may be duly adopted in place thereof. 

  
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 “Taxes”: All taxes, assessments and charges of every kind and
nature levied, assessed or imposed at any time by any governmental authority upon or against the Property or any improvements, fixtures and equipment of Landlord used in the operation thereof whether such taxes and assessments are general or
special, ordinary or extraordinary, foreseen or unforeseen in respect of each Tax Year falling wholly or partially within the Term. Taxes shall include, without limitation, all general real property taxes and general and special assessments
(provided that, with respect to any special assessments or betterments that may be paid in installments, Taxes for such Tax Year shall include only the amount of the installment plus any interest due and payable during such Tax Year), charges, fees
or assessments for all governmental services or purported benefits to the Property, service payments in lieu of taxes, all business privilege taxes, and any tax, fee or excise on the act of entering into this Lease or any other lease of space in the
Property, or on the use or occupancy of the Property or any part thereof, or on the rent payable under any lease or in connection with the business of renting space under any lease or in connection with the business of renting space in the Property,
that are now or hereafter levied or assessed against Landlord by the United States of America, the Commonwealth of Massachusetts, or any political subdivision, public corporation, district or other political or public entity, including legal fees,
experts’ and other witnesses’ fees, costs and disbursements incurred in connection with proceedings to contest, determine or reduce Taxes. Taxes shall also include any other tax, fee or other excise, however described, that may be levied
or assessed as a substitute for, or as an addition to, in whole or in part, any other Taxes (including, without limitation, any municipal income tax) and any license fees, tax measured or imposed upon rents, or other tax or charge upon
Landlord’s business of leasing the Property, whether or not now customary or in the contemplation of the parties on the date of this Lease. Taxes shall not include: (a) franchise, transfer, gift, excise, capital stock, estate, succession
and inheritance taxes, and federal and state income taxes measured by the net income of Landlord from all sources, unless due to a change in the method of taxation such tax is levied or assessed against Landlord as a substitute for, or as an
addition to, in whole or in part, any other Tax that would constitute a Tax as provided above; or (b) penalties or interest for late payment of Taxes except to the extent arising from Tenant’s failure to pay such amounts. 

“Expense Year”: Each calendar year, all or any portion of which shall occur during the Term of this Lease. 

“Operating Expenses”: All costs and expenses (and taxes, if any, thereon) paid or incurred on behalf of
Landlord (whether directly or through independent contractors) in connection with the ownership, management, operation, maintenance and repair of the Property and Common Areas (including any sales or other taxes thereon) during the Term as a
first-class office park, including, without limitation: 
 (a)    supplies, materials and equipment
purchased or rented, total wage and salary costs paid to, and all contract payments made on account of, all persons to the extent engaged in the operation, maintenance, security, cleaning and repair of the Building and the Common Areas at or below
the level of building manager (including the amount of any taxes, social security taxes, unemployment insurance contributions, union benefits) and any on-site employees of Landlord’s property management
agent; 
 (b)    the maintenance, repair and replacement of building systems, including heating,
ventilating, air conditioning, plumbing, electrical, mechanical, sewer, fire detection, sprinkler, life safety and security systems, telecommunications facilities, elevators and escalators, exterior windows and doors, tenant directories, emergency
generator, and other equipment used in common by, or for the benefit of, occupants of the Building and Common Areas including such repairs and replacements as may be necessary to maintain the same in proper working order and in compliance with all
applicable laws and industry performance standards; 
 (c)    charges of contractors for services and
facilities otherwise includable in Operating Expenses, including security, trash removal, cleaning, janitorial, window washing, snow and ice removal, exterior and interior landscaping, the maintenance and repair of the parking facilities, roadways
and light poles; 
 (d)    the cost of utility services for the Building and the Common Areas, including,
without limitation, water, sanitary sewer, electricity, gas, fuel oil, steam, chilled water; but excluding electricity supplied to the Premises and billed to Tenant pursuant to Section 5.4 and electricity used by other tenants of the Property
within their leased space and billed directly to such tenants; 

  
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 (e)    the premiums for fire, extended coverage, loss of
rents, boiler, machinery, sprinkler, public liability, property damage, earthquake, flood, and other insurance relative to the Property and the operation and maintenance thereof (including the fitness center described below) and unreimbursed costs
incurred by Landlord that are subject to commercially reasonable insurance deductibles; 
 (f)    the
operation and maintenance of any areas, facilities and amenities located in Common Areas , including, without limitation, the cost of utilities, repairs and insurance associated with such amenities; 

(g)    the amortized cost of capital items incurred with respect to the ownership, operation, maintenance
and repair of the Property for maintenance, repairs, and replacements (i.e., capital expenditures of any kind, whether for repairs, replacements or improvements) amortized over the reasonable life of the capital items as determined in the reasonable
judgment of Landlord’s accountant in accordance with generally accepted accounting principles together with interest at the greater of nine percent (9%) per annum or Landlord’s borrowing rate for such capital items on the unamortized
balance of the cost of the capital item and the installation of capital improvements that are made to the Property by Landlord in order to: (i) reduce (or avoid an increase in) operation or maintenance expenses with respect to the Property,
(ii) comply with laws, regulations or orders of any governmental or quasi-governmental authority, agency or department which were enacted or became effective after the date hereof, or (iii) comply with the requirements of Landlord’s
insurers that are enacted or became effective after the date hereof; 
 (h)    office costs of
administration; legal and accounting fees and other expenses of maintaining and auditing Property accounting records and preparing Landlord’s Statements; 

(i)    a commercially reasonable fee for management services whether rendered by Landlord (or affiliate) or
a third-party property manager, it being agreed that 4% of gross revenues from the Property constitutes a commercially reasonable management fee; and 

(j)    the cost of operating, cleaning and maintaining the Cafeteria and Fitness Center described in
Section 6.6, below, if any (net of revenue, if any, collected from the operation of such cafeteria and fitness center). 

In no event shall Landlord be entitled to payment of more than 100% of the Operating Expenses from tenants of the Property in any one Expense
Year during the Term. 
 Notwithstanding anything herein to the contrary, Operating Expenses shall not include: (1) utility expenses
that are separately metered for any individual tenant in the Property; (2) any expense for which Landlord is reimbursed by a specific tenant by reason of a special agreement or requirement of the occupancy of the Property by such tenant;
(3) expenses for services provided by Landlord for the exclusive benefit of a given tenant or tenants for which Landlord is directly reimbursed by such tenant or tenants; (4) all costs, fees and disbursements relating to activities for the
solicitation, negotiation and execution of leases for space in the Property (including but not limited to advertising costs, leasing commissions and attorneys’ fees therefor); (5) the costs of alterations to or payment of allowance for, or the
decorating or the redecorating of, space in the Property leased to other tenants; (6) except as stated in subparagraph (h) of the definition of Operating Expenses, the costs associated with the operation of the business of the ownership or
entity which constitutes “Landlord”, including costs of selling, syndicating, financing or mortgaging any of Landlord’s interest in the Property; (7) rentals payable under any ground or underlying lease, if any; (8) except
as stated in subparagraph (g) of the definition of Operating Expenses, depreciation, interest and principal payments on mortgages and other debt costs, if any; (9) repairs or other work required due to fire or other casualty except to the
extent of any commercially reasonable deductible; (10) except as set forth in subparagraph (g), costs of capital improvements; (11) payments to affiliates of Landlord, but only to the extent that they exceed market charges (the parties
agreeing that a property management fee equal to 4% of gross rents is permissible under this clause (11)); (12) costs of constructing any additional buildings or, except as set forth in subparagraph (g) above, improvements; (13) any
increase in the cost of Landlord’s insurance caused by a specific use of another tenant; (14) attorneys’ fees, costs, disbursements, and other expenses incurred in connection with the disputes with tenants; (15) rent for space
which is not actually used by Landlord in connection with the management and operation of the Property; (16) all costs or expenses (including fines, penalties and legal fees) incurred due to the violation by Landlord, its employees, agents,

  
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contractors or assigns of the terms and conditions of any lease, or any applicable building code, governmental rule, regulation or law; (17) contingency or replacement reserves;
(18) costs incurred in remediation of the Property required as the result of Hazardous Substances therein or thereon; (19) except as permitted in subparagraph (g) above, any capital cost incurred in connection with modifying,
removing, upgrading or replacing the Building Systems (as hereinafter defined); (20) costs, other than those incurred in ordinary maintenance and repair, for sculptures, paintings, fountains or other objects of art or the display of such item;
(21) contributions to charitable or political organizations; (22) Taxes; (23) the cost of repairs or other work to the extent Landlord is reimbursed by insurance or condemnation proceeds, by other tenants (other than through the payment of
Operating Expenses) or from any other source, or for which Landlord would have been reimbursed by insurance which Landlord is required to carry under this Lease (whether or not Landlord does so); (24) costs incurred in connection with the sale,
financing or refinancing of the Property or any portion thereof; (25) fines, interest and penalties incurred due to the late payment of Taxes or Operating Expenses except to the extent resulting from Tenant’s failure to timely pay Taxes or
Operating Expenses; (26) insurance deductibles in excess of commercially reasonable deductibles; and (27) the amount of a judgment or settlement against Landlord which is not covered by the insurance required to be carried by Landlord
under this Lease. 
 Operating Expenses that are incurred jointly for the benefit of the Building and one or more other buildings or
properties, whether pursuant to a reciprocal easement agreement, common area agreement or otherwise, may be allocated between the Building and the other buildings or properties in accordance with the ratio of their respective rentable areas
calculated using a consistent methodology or on any other reasonable basis determined by Landlord. Operating Expenses incurred for the benefit of less than all of the tenants at the Property or in the Building may be allocated among such tenants
based on the rentable square footage of their respective premises or on any other reasonable basis determined by Landlord. 

“Tenant’s Share”: Tenant’s
Share shall be a fraction, the numerator of which shall be the rentable area of the Premises and the denominator of which (i) shall be the rentable area of the Building, with respect to Operating Expenses of and pertaining to the Building, and
(ii) the rentable area of the Property, with respect to Operating Expenses of and pertaining to the office park at the Property. On the Commencement Date the Tenant’s Share pertaining to the Property is 10.50% (50,000 RSF/476,207 RSF), and
the Tenant’s Share pertaining to the Building is 100% (50,000 RSF/50,000 RSF). The Tenant’s Share shall be recalculated from time to time in the event that there shall be a change in the rentable area of either the Premises, the Building,
or the Property. For purposes hereof, Operating Expenses shall be allocated either to the Building or the office park at the Property, but not both (i.e., the provisions of this paragraph shall not operate to enable Landlord to charge Tenant for the
same Operating Expense twice). 
 “Landlord’s
Statement”: An instrument containing a computation of any Additional Rent for Operating Expenses or Taxes due pursuant to the provisions of this Article 5. 

5.2    Payment of Taxes. Tenant shall pay, as Additional Rent, Tenant’s Share of Taxes
payable in respect of any Tax Year falling wholly or partially within the Term (which payment shall be adjusted by proration with respect to any such partial Tax Year). Within thirty (30) days after the issuance by the Town of Bedford or other
applicable governmental authority of the final bill for Taxes for each Tax Year, Landlord shall submit to Tenant a copy of such bill, together with Landlord’s Statement and Tenant shall pay the Additional Rent set forth on such Landlord’s
Statement (less the amount of estimated payments paid by Tenant on account of prior estimated payments in accordance with this paragraph, if any) as set forth herein. Landlord, at its option, may require Tenant to make monthly payments on account of
Tenant’s Share of Taxes. The monthly payments shall be one-twelfth (1/12th) of the amount of Tenant’s Share of Taxes and shall be payable on or before the first day of each month during the Term, in
advance, in an amount reasonably estimated by Landlord and billed by Landlord to Tenant; provided, that, Landlord shall have the right initially to determine such monthly estimates and to reasonably revise such estimates from time to
time. Notwithstanding the foregoing, any change in the monthly payments required to be made by Tenant under this Section 5.2 shall not be effective until thirty (30) days after receipt by Tenant of notice of such
change. 
 5.3    Payment of Operating Expenses. Tenant shall pay to Landlord, as Additional
Rent, Tenant’s Share of all Operating Expenses in respect of each Expense Year. Tenant shall pay a sum equal to one-twelfth (1/12) of the amount of Tenant’s Share of Operating Expenses for each
Expense Year on or before the first day of each month of such Expense Year, in advance, in an amount 

  
 9 

 
reasonably estimated by Landlord and billed by Landlord to Tenant; provided, that, Landlord shall have the right initially to determine such monthly estimates and to reasonably
revise such estimates from time to time. Notwithstanding the foregoing, any change in the monthly payments required to be made by Tenant under this Section 5.3 shall not be effective until thirty (30) days after
receipt by Tenant of notice of such change. 
 5.4    Payment of Utility Expenses. The
Building is separately metered for electrical service, water and sewer service and gas service. Water and sewer service is not billed directly to Tenant, and Tenant pays for its water and sewer service as a part of Tenant’s Share of Operating
Expenses. Tenant shall take all steps required by the applicable utility company to provide for direct billing to Tenant for the electricity and gas furnished to the Premises during the Term, including, without limitation, making applications to the
applicable utility company in connection with such service and making any deposits as such utility company shall require. Tenant agrees to pay, or cause to be paid, all charges for electricity and gas furnished to the Premises (or by special
facilities serving the Premises, if any) during the Term, punctually as and when due. From time to time, if requested by Landlord, Tenant shall provide Landlord with evidence of payment to, and good standing with, such utility companies as Landlord
may reasonably require. Tenant covenants and agrees to indemnify, hold harmless and defend Landlord against all liability, cost and damage arising out of or in any way connected to Tenant’s non-payment or
late payment of any and all charges and rates and deposits to such utility companies relating to the Premises during the Term. 
 If at any
time during the Term the Building is not separately metered for electricity and payments on account of electricity are made to Landlord, Landlord shall bill Tenant for such usage based on Landlord’s reasonable estimate (taking into account
Tenant’s prior usage of electricity) and Tenant’s rate of payment shall increase from time to time based upon the increases in rate charged by the utility company to Landlord. Landlord shall have the right to issue supplemental billing to
Tenant from time to time to account for such increases. Any electrical charges payable to Landlord in respect of the Premises shall constitute Additional Rent under this Lease (but shall not be included as an Operating Expense), and shall be due and
payable monthly in advance on the first day of each calendar month during the Term. In such event, Landlord shall have the right to charge Tenant an estimated amount, payable as Additional Rent on the first of each month, in advance, together with
payments of Base Rent, on account of Tenant’s estimated electricity usage, with an annual reconciliation based on actual meter readings such that Tenant will pay the amount due hereunder. 

5.5    Landlord’s Statements. 

5.5.1    Delivery of Statements. Landlord will deliver Landlord’s Statements to Tenant during the Term.
Landlord shall endeavor, within one hundred twenty (120) days after the expiration of each Expense Year, to prepare and furnish Tenant with Landlord’s Statement showing the Operating Expenses and Taxes incurred during such Expense Year.
Landlord’s delay or failure to render Landlord’s Statement with respect to any Expense Year or any Tax Year beyond a date specified herein shall not prejudice Landlord’s right to render a Landlord’s Statement with respect to that
or any subsequent Expense Year or subsequent Tax Year. The obligations of Landlord and Tenant under the provisions of this Article with respect to any Additional Rent incurred during the Term shall survive the expiration or any sooner termination of
the Term. If Landlord fails to give Tenant a statement of projected Operating Expenses prior to the commencement of any Expense Year, Tenant shall continue to pay Operating Expenses in accordance with the previous statement, until Tenant receives a
new statement from Landlord. Landlord’s Statements with respect to Operating Expenses and Taxes shall be conclusive between the parties absent manifest error, subject to the provisions of Section 5.5.2, below. 

5.5.2    Tenant Inspection Rights. During the one hundred twenty (120)-day
period after receipt of any Landlord’s Statement with respect to Operating Expenses and Taxes (the “Review Period”), Tenant may inspect and audit Landlord’s records relevant to the cost and expense items reflected in such
Landlord’s Statement (a “Tenant Audit”) at a reasonable time mutually agreeable to Landlord and Tenant during Landlord’s usual business hours. Each Landlord’s Statement shall be conclusive and binding upon Tenant
unless within one hundred eighty (180) days after receipt of such Landlord’s Statement Tenant shall notify Landlord that it disputes the correctness of Landlord’s Statement, specifying the respects in which Landlord’s Statement
is claimed to be incorrect. Tenant’s right to conduct any Tenant Audit shall be conditioned upon the following: (a) no Event of Default shall be ongoing at the time that Tenant seeks to conduct the Tenant Audit; (b) in no event shall
any Tenant Audit be performed by a firm retained on a “contingency fee” basis; (c) the Tenant Audit shall be concluded no 

  
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later than sixty (60) days after Landlord first makes its records available to Tenant for inspection and audit; (d) any Tenant Audit shall not unreasonably interfere with the conduct of
Landlord’s business; (e) Tenant and its agent conducting the Tenant Audit shall each execute a commercially reasonable confidentiality agreement for Landlord’s benefit prior to commencing any Tenant Audit; (f) Tenant’s
agent’s audit report shall, at no charge to Landlord, be submitted in draft form for Landlord’s review and comment before the final approved audit report is delivered to Landlord, and Landlord shall have the right to point out errors or
make suggestions with respect to such audit report, and any appropriate comments or clarifications by Landlord which are accepted by Tenant’s agent shall be incorporated into the final audit report, it being the intention of the parties that
Landlord’s right to review is intended to prevent errors and avoid the dispute resolution mechanism set forth below and not to unduly influence Tenant’s agent in the preparation of the final audit report; (g) Tenant shall only be able
to conduct one (1) Tenant Audit for each Lease Year during the Term; and (h) the Tenant Audit shall be conducted by Tenant at its sole cost and expense unless the results of such Tenant Audit show that Landlord’s Statement overstated
the amount of Operating Expenses and Taxes owed by Tenant for the period covered by the Tenant Audit by more than five percent (5%), in which case Landlord shall be responsible for payment of such costs and expenses within thirty (30) days
after receipt by Landlord of an invoice therefor. If Tenant makes a timely objection, Tenant shall nonetheless pay the amount shown on the Landlord’s Statement in the manner prescribed in this Lease, without any prejudice to such objection,
however, any overpayments identified during any Tenant Audit, if any, shall be applied as a credit against the amount of Additional Rent owed by Tenant immediately following the completion of the Tenant Audit. 

5.6    Adjustments. If the actual amount of Tenant’s Share of Operating Expenses for any
Expense Year or Tenant’s Share of Taxes for any Tax Year exceeds the estimated amount thereof paid by Tenant for such Expense Year or Tax Year, then Tenant shall pay to Landlord the difference between the estimated amount paid by Tenant and the
actual amount of such Additional Rent payable by Tenant. This Additional Rent payment shall be due and payable within thirty (30) days following delivery of Landlord’s Statement. If the total amount of estimated payments made by Tenant in
respect of Tenant’s Share of Operating Expenses for any Expense Year or Tenant’s Share of Taxes for any Tax Year shall exceed the actual amount of such Additional Rent payable by Tenant, then such excess amount shall be credited against
the monthly installments of Additional Rent due and payable from Tenant to Landlord hereunder until such amount shall have been refunded in full to Tenant after delivery of the applicable Landlord’s Statement. Any excess payments made by Tenant
during the Term that have not been so applied and are outstanding at the end of the Term shall be paid to Tenant promptly following delivery of Landlord’s Statement for the final Expense Year and final Tax Year, as applicable. Tenant’s
obligations under this Section 
5.6 shall survive the expiration or earlier termination of the Term. 
 ARTICLE
6    SERVICES AND UTILITIES 
 6.1    Services. Landlord shall
provide the following services to the Building and the Common Areas, as applicable (subject to Tenant’s reimbursement and payment obligations therefor in accordance with the operation of Article 5 hereof): 

(a)    Janitor services in and about the office and laboratory portions of the Premises in accordance with
the cleaning specifications set forth in Exhibit 6.1, Saturdays, Sundays and union and state and federal government holidays (the “Holidays”) excepted. In addition, Landlord shall strip and
re-wax the laboratory floors on a semi-annual basis. 

(b)    Heat and air-conditioning to the Building as required to
maintain comfortable temperature 24 hours per day, 7 days per week; provided, however, Tenant shall be responsible for all utility services and the cost of the same necessary to produce such heat and air-conditioning in accordance with
Section 5.4, above, and Tenant shall pay an additional charge for the use of the heating, air conditioning, and ventilation by Tenant for the office portions of the Premises after Normal Business Hours (“Overtime
HVAC”) in accordance with Section 6.2, below. The expense charged by Landlord to Tenant for any Overtime HVAC shall be based on Landlord’s actual cost for such service (currently $20.00 per hour), but subject
to change from time to time based on Landlord’s actual cost to provide such service. 
 (c)    Hot
running water for lavatory purposes and for laboratory, pilot production and research and development purposes, at the levels existing as of the date hereof, and cold water to the Building for cleaning, fire protection, drinking, lavatory and toilet
purposes, and for laboratory, pilot production and research and development purposes, at the levels existing as of the date hereof, drawn through fixtures installed by Landlord or by Tenant with Landlord’s written consent, which consent shall
not be unreasonably withheld, conditioned or delayed. 

  
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 (d)    Maintenance of the Common Areas so that they are
clean and free from accumulations of debris, rubbish and garbage and exterior drives, walkways and parking areas free of accumulations of snow and otherwise in good order, condition and repair. 

(e)    Access to the Premises and the Common Areas serving the Building twenty-four (24) hours per
day, seven (7) days per week, fifty-two (52) weeks per year, except for emergency situations outside of Landlord’s control and subject to Landlord’s Rules and Regulations. Other services
shall be available as provided in Section 6.2 hereof. 
 Landlord shall have the right to select the utility providers (except to
the extent that Tenant contracts directly with such providers) and Tenant shall pay all actual costs associated with obtaining the utility service as provided in Article 5 hereof. Landlord agrees to furnish or cause to be furnished to the
Premises the utilities and services described herein, subject to the conditions and in accordance with the standards set forth herein. Landlord’s failure to furnish any of such services when such failure is caused by accidents, the making of
repairs, alterations or improvements, labor difficulties, difficulty in obtaining adequate supply of fuel, electricity, steam, water or other service or supplies from the sources from which they are usually obtained for the Building, or governmental
constraints or any other cause beyond Landlord’s reasonable control, shall not result in any liability to Landlord. Tenant shall not be entitled to any abatement or reduction of rent by reason of such failure, no eviction of Tenant shall result
from such failure and Tenant shall not be relieved from the performance of any covenant or agreement in this Lease. In the event of any failure, stoppage or interruption thereof, Landlord shall diligently attempt to resume service promptly. 

Notwithstanding the foregoing, if there shall be an interruption, curtailment or suspension of any utility or service necessary for the occupancy of the
Premises and required to be provided by Landlord pursuant to this Section 6.1 (and no reasonably equivalent alternative service or utility is provided by Landlord) that shall materially interfere with Tenant’s use and
enjoyment of all or a material portion of the Premises (a “Service Interruption”), and if (i) such Service Interruption shall continue for five (5) consecutive business days following receipt by
Landlord of written notice from Tenant describing such Service Interruption (the “Service Interruption Notice”), (ii) such Service Interruption is not the result of Force Majeure or any of Tenant’s acts or
omissions, and (iii) the restoration of such Service Interruption is in the reasonable control of Landlord, then Tenant shall be entitled to an equitable abatement of Base Rent and Tenant’s Share of Operating Expenses and Taxes, based on
the nature and duration of the Service Interruption, the area of the Premises affected, and the then current Base Rent and Tenant’s Share of Operating Expenses and Taxes, for the period that shall begin on the 6th day of such Service
Interruption and that shall end on the day such Service Interruption ceases. Notwithstanding anything in this Lease to the contrary, but subject to Article 10 and Article 11 (which shall govern in the event of a casualty or
condemnation), the remedies expressly provided in this paragraph shall be Tenant’s sole recourse and remedy in the event of an interruption of Landlord services to the Premises. 

6.2    Additional Services. Landlord shall impose reasonable charges and may establish
reasonable rules and regulations for the following: (a) following a request therefor by Tenant or following prior notice to Tenant by Landlord, the use of any heating, air-conditioning, ventilation by
Tenant for the office portion of the Premises after Normal Business Hours (provided that any such charge for such use shall be in accordance with Section 6.1, above), (b) following a request therefor by Tenant or following prior notice to
Tenant by Landlord, the use or consumption of any other building services, supplies or utilities after Normal Business Hours, and any unanticipated, additional costs incurred by Landlord to operate the Building after Normal Business Hours as a
result thereof; (c) if Landlord has provided Tenant with prior notice, additional or unusual janitorial services required because of any non-building standard improvements in the Premises, the
carelessness of Tenant, or the nature of Tenant’s business; and (d) the removal of any refuse and rubbish from the Premises except for discarded material placed in wastepaper baskets and left for emptying as an incident to Landlord’s
normal cleaning of the Premises in accordance with Exhibit 6.1. For the purposes of this Lease, “Normal Business Hours” shall mean the hours of 7:00 a.m. to 7:00 p.m., Monday through Friday (other than
Holidays). 

  
 12 

 6.3    Excessive Current. 

6.3.1    Prohibited Activities. Tenant shall comply with the conditions of occupancy and connected
electrical load reasonably established by Landlord for the Building. Tenant covenants that at no time shall the use of electrical energy in the Premises exceed the capacity of the existing feeders or wiring installations then serving the Premises.

 6.3.2    Landlord’s Right to Survey Usage. Landlord may survey Tenant’s use of
services from time to time. If Tenant ceases to lease 100% of the Premises initially leased hereunder, Landlord shall have the right to redistribute electricity in the Building at its sole cost and expense to provide for a minimum level of
electrical load to any other tenant’s premises in the Building consistent with first class office use. 

6.4    Maintenance of Common Areas. The manner in which the Common Areas are maintained and operated and the
expenditures therefor shall be at the sole discretion of Landlord and in accordance with the standards of comparable buildings in the Bedford submarket of the Route 128 North submarket. Landlord reserves the right from time to time to (a) make
changes in the shape, size, location and appearance of the land and improvements which constitute the Common Areas, provided that with respect to Common Areas in the Building or solely serving the Building, Landlord shall not materially impair
Tenant’s ability to operate its business in or reasonable access to the Premises, except temporary impairments required by said changes; (b) make such improvements, alterations and repairs to the Common Areas as may be required by
governmental authorities or by utility companies servicing the Property; (c) construct, maintain and operate lighting and other facilities on all said areas and improvements; (d) grant exclusive parking rights to Property tenants (except
in or to the Tenant’s Visitor Parking Area); and (e) to add or remove improvements and facilities to or from the Common Areas (except in or to the Tenant’s Visitor Parking Area). The use of the Common Areas shall be subject to such
reasonable regulations and changes therein as Landlord shall make from time to time, including (but not by way of limitation) the right to close from time to time, if necessary, all or any portion of the Common Areas to such extent as may be legally
sufficient, in the opinion of Landlord’s counsel, to prevent a dedication thereof or the accrual of rights of any person or of the public therein; provided, however, Landlord shall do so at such times and in such manner as shall minimize any
disruption to Tenant to the extent reasonably possible. Notwithstanding anything contained herein, Landlord shall not grant to any non-tenant of the Building any rights with respect to the Building that are
effective during the Term. 
 Landlord further reserves the right to add to the Property and to develop and finance additions and other
improvements in the Common Areas of the Property as it may determine in its discretion. This may entail subdivision of the land at the Property (except in or to the Tenant’s Visitor Parking Area), a separate ground lease of a portion of the
land at the Property, or creation of a condominium or common interest community in a manner that allows development of any addition or other improvements as an independent project. In the case of the development of any addition or other improvements
as an independent project, the same shall be excluded from the term “Property” as used in this Lease. In the event any land is added to the Property, Exhibit 1.1-2 shall be deemed amended
accordingly. In the event the Property, as originally defined herein, is subdivided, then the term “Property” shall be deemed to refer only to the parcel or parcels of land on which the Building is located and Exhibit 1.1-2 shall be deemed amended accordingly. In the event the Property is submitted to a condominium regime, the Property shall be deemed to be the condominium unit in which the Building is located and all common
areas and facilities of the condominium. This Lease shall be subject and subordinate to any such subdivision, ground lease, or condominium (and covenants and easements granted in connection therewith) so long as the same do not, in any material
respect, reduce Landlord’s obligations under this Lease, increase Tenant’s obligations under this Lease, or reduce Tenant’s rights under this Lease. Tenant agrees to enter into any instruments reasonably requested by Landlord in
connection with the foregoing so long as the same are not inconsistent with the rights of Tenant under this Lease, including a subordination of this Lease to a ground lease or documents creating a condominium or common interest community at the
Property. Tenant agrees not to take any action to oppose any application by Landlord for any permits, consents or approvals from any governmental authorities for any redevelopment or additional development of all or any part of the Property, and
will use all commercially reasonable efforts to prevent any of Tenant’s subtenants or assigns, and Tenant’s and their respective officers, directors, employees, agents, contractors and consultants (collectively, “Tenant Responsible
Parties”) from doing so. For purposes hereof, action to oppose any such application shall include, without limitation, communications with any governmental authorities requesting that any such application be limited or altered. Also for
purposes hereof, commercially reasonable efforts shall include, without limitation, commercially reasonable efforts, upon receiving notice of any such action to oppose any application on the part of any Tenant Responsible Parties, to obtain
injunctive relief, and, in the case of a subtenant, exercising remedies against the subtenant under its sublease. 

  
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 6.5    Access to Premises. 

6.5.1    Landlord’s Right of Entry. Landlord shall have the right to enter the Premises without
abatement of Rent at all reasonable times upon reasonable prior notice to Tenant (except in emergencies when no advance notice shall be required), (a) to supply any service to be provided by Landlord to Tenant hereunder, (b) to show the
Premises to Landlord’s Mortgagee (as hereinafter defined) and to prospective purchasers, mortgagees and tenants, (c) to inspect, alter, improve or repair the Premises and any portion of the Property, and (d) to introduce conduits,
risers, pipes and ducts to and through the Premises, provided that in exercising any such right, Landlord will cause all such conduits, risers, pipes and ducts to be placed above dropped ceilings, within walls, or below floors or in closets, to the
extent reasonably practicable. In conducting any such activities, Landlord shall use reasonable efforts not to unreasonably interfere with the conduct of Tenant’s business operations in or access to the Premises or Tenant’s Equipment in a
manner inconsistent with first-class buildings. 
 Notwithstanding the foregoing, Tenant may identify certain areas of the
Premises not to exceed 15,000 rentable square feet in the aggregate that require limited access and special security measures (“Secure Areas”) by written notice to Landlord from time-to-time. Landlord shall not enter the Secure Areas without being accompanied by a representative of Tenant except in the event of an emergency threatening life or property or to provide services required
to be provided to Tenant by Landlord pursuant to this Lease, or otherwise with Tenant’s prior consent. 
 Landlord shall
cause its janitorial vendors cleaning the laboratory and any Landlord personnel entering portions of the Secure Areas that are used for laboratory or pilot production purposes to comply with Tenant’s reasonable and appropriate safety procedures
and Tenant shall cooperate with Landlord and such persons to provide the necessary training for such procedures. 

6.5.2    Tenant’s Keys. For each of the purposes stated above in this
Section 6.5, Landlord shall at all times have and retain a key with which to unlock all of the doors in, upon and about the Premises, excluding Tenant’s vaults, safes and Secure Areas, and Landlord shall have the right
to use any and all means that Landlord may deem necessary or proper to open said doors in an emergency, in order to obtain entry to any portion of the Premises. 

6.6    Cafeteria and Fitness Center. The Common Areas may contain a fitness center (the “Fitness
Center”) and a cafeteria (the “Cafeteria”) that will be operated and maintained by Landlord (or an operator selected by Landlord). The Cafeteria and Fitness Center, if any, may not be temporarily available from time to time
due to construction activities, repairs, maintenance or alterations, or a change in the managing or operating company hired by Landlord, and Landlord reserves the right to change the use of such facilities if the same is uneconomic or insufficiently
used by tenants of the Building or Property in which case such facilities shall be subject to discontinuance and removal by Landlord, as determined by Landlord in its sole discretion. Landlord agrees to make the Fitness Center (and its facilities
and equipment), if any, available to Tenant’s employees on a direct, non-exclusive basis subject to (a) Landlord’s Rules and Regulations regarding the use thereof; (b) payment of a monthly
or other periodic user fee (no such fee being applicable as of the date hereof); and (c) execution of a waiver of liability and indemnity agreement for Landlord’s benefit in form and substance satisfactory to Landlord prior to such
person’s use of the Fitness Center. If, at any time, the Fitness Center and/or Cafeteria are located within the Property in an area outside of the Building, Tenant acknowledges and agrees that Tenant’s use of such facilities shall be
subject to discontinuance if the Building and Property are no longer owned by the same entity. 
 ARTICLE
7    CONDUCT OF BUSINESS BY TENANT 
 7.1    Permitted Use. The Premises shall be
used and occupied only for general office, general laboratory, and research and development purposes, together with customary uses accessory thereto including ancillary pilot production and ancillary storage, as permitted per Applicable Laws
(collectively, the “Permitted Uses”), but expressly excluding medical, clinical, government and education (as distinguished from training of staff) offices. Tenant shall not use or occupy, or permit the use or occupancy of, the
Premises or any part thereof for any use other than the Permitted Uses specifically set 

  
 14 

 
forth above or in any illegal manner, or in any manner that, in Landlord’s reasonable judgment, would adversely affect or interfere with any services required to be furnished by Landlord to
Tenant or to any other tenant or occupant of the Property, or with the proper and economical rendition of any such service, or with the use and enjoyment of any part of the Property by any other tenant or occupant. In no event shall the Permitted
Uses include any governmental, medical, clinical or retail uses. Tenant agrees that it will not exceed the maximum floor bearing capacity for the Premises. 

7.2    Tenant’s Personal Property. Tenant shall be responsible for any ad valorem taxes on (a) its
personal property (whether owned or leased) and (b) on the value of its leasehold improvements in the Premises (which are in excess of building standard improvements), if and to the extent that the leasehold improvements are assessed in a
manner segregating their value from the remainder of the Building by the taxing authorities as reasonably evidenced by Landlord, and such taxes shall be payable by Tenant to Landlord as Additional Rent. Landlord acknowledges that no leasehold
improvements in the Premises are currently assessed separately from the remainder of the Building. 

7.3    Compliance with Laws. 

7.3.1    Tenant’s Compliance Obligations. From and after the Commencement Date and during the
Term or such longer period as Tenant remains in possession of the Premises, Tenant, at Tenant’s expense, shall comply promptly with the laws, ordinances, rules, regulations and orders of all governmental authorities in effect from time to time
during the Term including, without limitation, the Americans with Disabilities Act (“ADA”), and all applicable federal, state and municipal building, zoning, fire, health, safety and environmental laws (the “Applicable
Laws”) that shall impose any duty on Tenant with respect to the Premises or the use, occupancy or operation thereof. Tenant will obtain and maintain in full force and effect any and all licenses and permits necessary for its use of the
Premises. Tenant shall make any Alterations in or to the Premises in order to comply with the foregoing, which are necessitated or occasioned, in whole or in part by the use or occupancy or manner of use, occupancy or operation of the Premises by
Tenant or any of its officers, employees, agents, contractors, invitees, licensees or subtenants (the “Tenant Parties”). Notwithstanding the foregoing, Tenant shall not be required to make any alterations or additions to the
structure, roof, exterior and load bearing walls, foundation, structural floor slabs and other structural elements of the Building or any Building Systems unless the same are (x) required by Tenant’s particular use of the Premises (as
opposed to office use, generally) or (y) result from any Alterations (as defined below) made by Tenant. 

7.3.2    Landlord’s Compliance Obligations. Landlord shall comply with all Applicable Laws in
effect from time to time during the Term that shall impose any duty on Landlord with respect to the Common Areas, excluding any matters that are Tenant’s responsibility under this Lease or the responsibility of other tenants of the Property.
Notwithstanding anything to the contrary contained herein, from and after the Commencement Date, Tenant shall be responsible for legal compliance, including the requirements of the ADA, with respect to (a) any and all requirements on account of
Tenant’s particular use of, or operations in, the Premises (as opposed to office use, generally), and (b) all Alterations designed or constructed by Tenant or its contractors or agents. 

7.4    Landlord’s Rules and Regulations. Tenant shall observe and comply with the rules and regulations
attached to this Lease as Exhibit 7.4, and all reasonable modifications thereof and additions thereto from time to time put into effect by Landlord (the “Rules and Regulations”). Tenant shall not use or permit the use of the
Premises in any manner that will create waste or a nuisance, or which shall tend to unreasonably disturb other tenants of the Property. Notwithstanding anything herein to the contrary, no rules or regulations, or modifications or additions thereto,
established or promulgated by Landlord under or pursuant to this Section 7.4 or any other provisions of this Lease shall be effective unless and until Landlord notifies Tenant thereof. Notwithstanding anything herein to the
contrary, if there is any conflict between any of the Rules and Regulations or any other rules and regulations promulgated or established by Landlord under or pursuant to this Section 7.4 or any other provisions of this
Lease and any of the other terms and provisions of this Lease, the other terms and provisions of this Lease shall govern. 

7.5    No Liens. Tenant shall keep the Premises and Property free from any liens or encumbrances arising out
of any work performed, material furnished or obligations incurred by or for Tenant or any person or entity claiming through or under Tenant. Any claim to, or lien upon, the Premises or the Property arising from any act or omission of Tenant shall
accrue only against the 

  
 15 

 
leasehold estate of Tenant and shall be subject and subordinate to the paramount title and rights of Landlord in and to the Premises and the Property. If any mechanics’ or other lien shall
be filed against the Premises or the Property purporting to be for services, labor or material furnished or to be furnished at the request of Tenant, then Tenant shall at its expense cause such lien to be discharged of record by payment, bond or
otherwise, within ten (10) days after Tenant has notice of the filing thereof. 
 7.6    Hazardous
Substances. 
 7.6.1    Tenant’s Obligations. 

7.6.1.1 Prohibitions. As a material inducement to Landlord to enter into this Lease with Tenant, Tenant has completed Landlord’s Pre-Leasing Environmental Exposure Questionnaire (the “Environmental Questionnaire”), which is attached as Exhibit 7.6.1.1. Subject to the provisions of the immediately following paragraph,
except for those chemicals or materials, and their respective quantities, specifically listed on the Environmental Questionnaire or an updated Environmental Questionnaire provided to Landlord subsequent to the execution hereof in accordance with
this Section 7.6, neither Tenant nor Tenant’s subtenants or assigns, or any of their respective employees, contractors and subcontractors of any tier, entities with a contractual relationship with such parties (other
than Landlord), or any entity acting as an agent or sub-agent of such parties or any of the foregoing (collectively, “Tenant Parties”) will produce, use, store or generate any “Hazardous
Substances”, as that term is defined below, on, under or about the Premises, nor cause or permit Tenant or any person or any entity claiming by, through, or under Tenant to cause any Hazardous Substance to be brought upon, placed, stored,
manufactured, generated, blended, handled, recycled, used or “Released”, as that term is defined below, on, in, under or about the Premises or Property. If any information provided to Landlord by Tenant on the Environmental Questionnaire,
or otherwise relating to information concerning Hazardous Substances is false, incomplete, or misleading in any material respect, the same shall be deemed a default by Tenant under this Lease. Landlord’s prior written consent shall be required
for any Hazardous Substances use for the Premises not described on the initial Environmental Questionnaire, such consent not to be unreasonably withheld, conditioned or delayed (but subject to the provisions of the immediately following paragraph).

 Notwithstanding the foregoing, Landlord agrees that Tenant may keep, maintain, use and/or store Hazardous Substances in the Premises that
are not listed on an Environmental Questionnaire if the same are (i) consistent with use by a first class laboratory in a mixed use office park and reasonably necessary for the conduct of Tenant’s business, and (ii) are otherwise
kept, maintained, used and stored in accordance with the provisions of this Lease. If requested by Landlord (not more than once per month) Tenant shall deliver updated MSDS sheets to Landlord with an updated inventory of Hazardous Substances
(including approximate amounts) used by Tenant or anyone claiming by, through or under Tenant at the Property if Tenant has, since the date of the last Environmental Questionnaire provided to Landlord, used any such new Hazardous Substances pursuant
to the terms of this paragraph. 
 Tenant shall not install or permit any underground storage tank at the Premises. In addition, Tenant
agrees that it: (i) shall not cause or, during the Term or such longer period as Tenant remains in possession of the Premises, suffer to occur, the Release (as defined below) of any Hazardous Substances at, upon, under or within the Premises or
the Property; and (ii) shall not engage in activities at the Premises that give rise to, or lead to the imposition of, liability upon Tenant or Landlord or the creation of an environmental lien or use restriction upon the Premises or the
Property. For purposes of this Lease, “Hazardous Substances” means all flammable explosives, petroleum and petroleum products, oil, radon, radioactive materials, toxic pollutants, asbestos, polychlorinated biphenyls
(“PCBs”), medical waste, chemicals known to cause cancer or reproductive 

  
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toxicity, pollutants, contaminants, hazardous wastes, toxic substances or related materials, including without limitation any chemical, element, compound, mixture, solution, substance, object,
waste or any combination thereof, which is or may hereafter be determined to be hazardous to human health, safety or to the environment due to its radioactivity, ignitability, corrosiveness, reactivity, explosiveness, toxicity, carcinogenicity,
infectiousness or other harmful or potentially harmful properties or effects, or defined as, regulated as or included in, the definition of “hazardous substances”, “hazardous wastes”, “hazardous materials”, or
“toxic substances” under any Environmental Laws. The term “Hazardous Substances” for purposes of this Lease shall also include any mold, fungus or spores, whether or not the same is defined, listed, or otherwise classified as a
“hazardous material” under any Environmental Laws, if such mold, fungus or spores may pose a risk to human health or the environment or negatively impact the value of the Premises. For purposes of this Lease, “Release” or
“Released” or “Releases” shall mean any release, deposit, discharge, emission, leaking, spilling, seeping, migrating, injecting, pumping, pouring, emptying, escaping, dumping, disposing, or other movement of
Hazardous Substances into the environment. 
 Notwithstanding anything contained herein to the contrary, in no event shall Tenant or anyone
claiming by through or under Tenant perform work at or above the risk category Biosafety Level 3 as established by the Department of Health and Human Services (“DHHS”) and as further described in the DHHS publication Biosafety
in Microbiological and Biomedical Laboratories (5th Edition) (as it may be or may have been further revised, the “BMBL”) or such nationally recognized new or replacement standards
as Landlord may reasonable designate. Tenant shall comply with all applicable provisions of the standards of the BMBL to the extent applicable to Tenant’s operations in the Premises. 

7.6.1.2 Notices to Landlord. Unless Tenant is required by Applicable Laws to give earlier notice to Landlord,
Tenant shall notify Landlord in writing as soon as possible but in no event later than five (5) days after (i) Tenant becomes aware of the occurrence of any actual, alleged or threatened Release of any Hazardous Substance in, on, under,
from, about or in the vicinity of the Premises (whether past or present), regardless of the source or quantity of any such Release, or (ii) Tenant becomes aware of any regulatory actions, inquiries, inspections, investigations, directives, or
any cleanup, compliance, enforcement or abatement proceedings (including any threatened or contemplated investigations or proceedings) relating to or potentially affecting the Premises, or (iii) Tenant becomes aware of any claims by any person
or entity relating to any Hazardous Substances in, on, under, from, about or in the vicinity of the Premises, whether relating to damage, contribution, cost recovery, compensation, loss or injury. Collectively, the matters set forth in clauses (i),
(ii) and (iii) above are hereinafter referred to as “Hazardous Substances Claims”. Tenant shall promptly forward to Landlord copies of all orders, notices, permits, applications and other communications and reports in
connection with any Hazardous Substances Claims. Additionally, Tenant shall promptly advise Landlord in writing of Tenant’s discovery of any occurrence or condition on, in, under or about the Premises that could subject Tenant or Landlord to
any liability, or restrictions on ownership, occupancy, transferability or use of the Premises under any “Environmental Laws”, as that term is defined below. Tenant shall not enter into any legal proceeding or other action, settlement,
consent decree or other compromise with respect to any Hazardous Substances Claims without first notifying Landlord of Tenant’s intention to do so and affording Landlord the opportunity to join and participate, as a party if Landlord so elects,
in such proceedings and in no event shall Tenant enter into any agreements which are binding on Landlord or the Property without Landlord’s prior written consent. Landlord shall have the right to appear at and participate in, any and all legal
or other administrative proceedings concerning any Hazardous Substances Claim. For purposes of this Lease, “Environmental Laws” means all applicable present and future laws relating to the protection of human health, safety,
wildlife or the environment, including, without limitation, (i) all requirements pertaining to reporting, licensing, permitting, investigation and/or remediation of emissions, discharges, Releases, or threatened Releases of Hazardous
Substances, whether solid, liquid, or gaseous in nature, into the air, surface water, groundwater, or land, or relating to the manufacture, processing, distribution, use, treatment, storage, disposal, transport, or handling of Hazardous Substances;
and (ii) all requirements pertaining to the health and safety of employees or the public. Environmental Laws include, but are not limited to, the Comprehensive 

  
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Environmental Response, Compensation and Liability Act of 1980, 42 USC § 9601, et seq., the Hazardous Materials Transportation Authorization Act of 1994, 49 USC § 5101, et seq., the
Solid Waste Disposal Act, as amended by the Resource Conservation and Recovery Act of 1976, and Hazardous and Solid Waste Amendments of 1984, 42 USC § 6901, et seq., the Federal Water Pollution Control Act, as amended by the Clean Water Act of
1977, 33 USC § 1251, et seq., the Clean Air Act of 1966, 42 USC § 7401, et seq., the Toxic Substances Control Act of 1976, 15 USC § 2601, et seq., the Safe Drinking Water Act of 1974, 42 USC §§ 300f through 300j, the
Occupational Safety and Health Act of 1970, as amended, 29 USC § 651 et seq., the Oil Pollution Act of 1990, 33 USC § 2701 et seq., the Emergency Planning and Community
Right-To-Know Act of 1986, 42 USC § 11001 et seq., the National Environmental Policy Act of 1969, 42 USC § 4321 et seq., the Federal Insecticide, Fungicide and
Rodenticide Act of 1947, 7 USC § 136 et seq., M.G.L. c.21C; oil and hazardous materials as defined in M.G.L. c.21E; and any other state or local law counterparts, as amended, as such Applicable Laws, are in effect as of the Lease Commencement
Date, or thereafter adopted, published or promulgated. 
 7.6.1.3 Releases of Hazardous Substances.
If there occurs any Release of any Hazardous Substance in, on, under, from or about the Premises during the Term or such longer period as Tenant remains in possession of the Premises in violation of Environmental Laws, or requiring any Clean-Up (as defined below), and such Release is not a Release for which Landlord is responsible as further set forth below, then, in addition to notifying Landlord as specified above, Tenant, at its own sole cost
and expense, shall (i) immediately comply with any and all reporting requirements imposed pursuant to any and all Environmental Laws, (ii) provide a written certification to Landlord indicating that Tenant has complied with all applicable
reporting requirements, (iii) take any and all necessary investigation, corrective, remedial and other Cleanup action in accordance with any and all applicable Environmental Laws, utilizing an environmental consultant approved by Landlord, all
in accordance with the provisions and requirements of this Section 7.6, including, without limitation, Section 7.6.6, and (iv) take any such additional investigative, remedial and corrective actions as
Landlord shall in its reasonable discretion deem necessary such that such Release is remediated to a level allowing unrestricted use of the Premises (i.e., to a level that will allow any future use of the Premises, including residential, without any
engineering controls or deed restrictions), all in accordance with the provisions and requirements of this Section 7.6. Landlord may, as required by any and all Environmental Laws, report the Release of any Hazardous
Substance to the appropriate governmental authority, and, if such Release is not a Release for which Landlord is responsible as further set forth below, identifying Tenant as the responsible party. Tenant shall deliver to Landlord copies of all
administrative orders, notices, demands, directives or other communications directed to Tenant from any governmental authority with respect to any Release of Hazardous Substances in, on, under, from, or near the Premises during the Term or such
longer period as Tenant remains in possession of the Premises, together with copies of all investigation, assessment, and remediation plans and reports prepared by or on behalf of Tenant, if any, in response to any such regulatory order or
directive. 
 Notwithstanding anything contained in this Section 7.6, if the presence or Release of
Hazardous Substances in, under, or about the Premises or elsewhere on the Property (a) is caused by Landlord or its agents, employees or contractors, or (b) results from the migration of such Hazardous Substances from outside the Premises
(but not due to the acts of Tenant or any Tenant Party), and in either event results in the contamination of the Premises or the Property, or any soil or groundwater in, under or about the Property, or (c) is caused by anyone other than Tenant
or any Tenant Party and is outside the Premises (collectively, “Excluded Matters”), Landlord at its own expense shall promptly take those actions necessary to abate, remove, remediate, or dispose of such
Hazardous Substances to the extent required by any Environmental Laws, and make all required submissions to applicable regulatory agencies regarding the same, and Tenant shall have no obligation other than to notify Landlord of any such Release of
which Tenant becomes aware. 
 7.6.2    Indemnification. 

7.6.2.1    In General. Without limiting in any way Tenant’s obligations
under any other provision of this Lease, Tenant shall be solely responsible for and shall protect, defend, indemnify and hold Landlord, its lenders, partners, subpartners and their respective officers, agents, servants, employees and independent contractors 

  
 18 

 
(collectively, the “Landlord Parties”) harmless from and against any and all claims, judgments, losses, damages, costs, expenses, penalties, enforcement
actions, taxes, fines, remedial actions, liabilities (including, without limitation, actual attorneys’ fees, litigation, arbitration and administrative proceeding costs, expert and consultant fees and laboratory costs) including, without
limitation, consequential damages (to the extent arising out of claims by third parties only, including without limitation governmental agencies, other tenants at the Property, and any subtenants) and sums paid in settlement of claims, which arise
during or after the Term, whether foreseeable or unforeseeable, arising out of or attributable to the presence, use, generation, manufacture, treatment, handling, refining, production, processing, storage, or presence—of Hazardous Substances
in, on, under or about the Premises or Property by any Tenant Party, except to the extent that such claims, judgments, losses, damages, costs, expenses, penalties, enforcement actions, taxes, fines, remedial actions or liabilities result or arise
from Excluded Matters. The foregoing obligations of Tenant shall include, without limitation: (i) the costs of any required or necessary removal, repair, cleanup or remediation of the Premises and Property, and the preparation and
implementation of any closure, removal, remedial or other required plans; (ii) judgments for personal injury or property damages; and (iii) all costs and expenses incurred by Landlord in connection therewith. 

7.6.3    Compliance with Environmental Laws. Without limiting the generality of
Tenant’s obligation to comply with Applicable Laws as otherwise provided in this Lease, Tenant shall, at its sole cost and expense, comply with all Environmental Laws that shall impose any duty on Tenant with respect to the Premises or the use,
occupancy or operation thereof by Tenant. Tenant shall obtain and maintain any and all necessary permits, licenses, certifications and approvals appropriate or required for the use, handling, storage, and disposal of any Hazardous Substances used,
stored, generated, transported, handled, blended, or recycled by Tenant on the Premises. Landlord shall have a continuing right, without obligation, to require Tenant to obtain, and to review and inspect any and all such permits, licenses,
certifications and approvals. Upon Landlord’s reasonable request following any allegation of a Hazardous Substances Claim received by Landlord or Landlord’s good faith belief that a Hazardous Substances Claim may occur, Tenant shall
provide Landlord with copies of Tenant’s Hazardous Substances management plans, any and all Hazardous Substances risk management and pollution prevention programs instituted by Tenant at the Premises, and any and all Hazardous Substances
emergency response and employee training programs respecting Tenant’s use of Hazardous Substances at the Premises. 

7.6.4    Assurance of Performance. 

7.6.4.1    Environmental Assessments In General. Landlord may, but shall not be required to,
engage from time to time such contractors as Landlord determines to be appropriate to perform “Environmental Assessments”, as that term is defined below, to ensure Tenant’s compliance with the requirements of this Lease with respect
to Hazardous Substances. For purposes of this Lease, “Environmental Assessment” means an assessment including, without limitation: (i) an environmental site assessment conducted in accordance with the then-current
standards of the American Society for Testing and Materials and meeting the requirements for satisfying the “all appropriate inquiries” requirements; and (ii) sampling and testing of the Premises based upon potential recognized
environmental conditions or areas of concern or inquiry identified by the environmental site assessment. 

7.6.4.2    Costs of Environmental Assessments. All costs and expenses incurred by Landlord in
connection with any such Environmental Assessment initially shall be paid by Landlord; provided that if any such Environmental Assessment shows that Tenant has failed to comply with the provisions of this Section 7.6 in any
material respect, then all of the costs and expenses of such Environmental Assessment shall be reimbursed by Tenant as Additional Rent within thirty (30) days after receipt of written demand therefor. 

7.6.5    Tenant’s Obligations upon Surrender. At the expiration or earlier termination of
the Term, Tenant, at Tenant’s sole cost and expense, shall: (i) cause an Environmental Assessment of the Premises to be conducted in accordance with Section 8.6.2; (ii) cause all Hazardous Substances (other

  
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than those for which Landlord is responsible as set forth above) to be removed from the Premises and disposed of in accordance with all Environmental Laws and as necessary to allow the Premises
to be used for any purpose; and (iii) cause to be removed all containers installed or used by any Tenant Parties to store any Hazardous Substances on the Premises, and cause to be repaired any damage to the Premises caused by such removal. 

7.6.6    Clean-up. 

7.6.6.1    Environmental Reports; Clean-Up.
If any written report, including any report containing results of any Environmental Assessment (an “Environmental Report”), shall indicate (i) the presence of any Hazardous Substances as to which Tenant
has a removal or remediation obligation under this Section 7.6. and (ii) that, as a result of such presence, the investigation, characterization, monitoring, assessment, repair, closure, remediation, removal, or other clean-up (the “Clean-up”) of any Hazardous Substances is required, Tenant shall promptly prepare and submit to Landlord within thirty
(30) days after receipt of the Environmental Report a comprehensive plan, subject to Landlord’s written approval, which approval shall not be unreasonably withheld, conditioned or delayed, specifying the actions to be taken by Tenant to
perform the Clean-up so that the Premises are restored to the conditions required by this Lease. Upon Landlord’s approval of the Clean-up plan, Tenant shall, at
Tenant’s sole cost and expense, without limitation of any rights and remedies of Landlord under this Lease, promptly implement such plan with a consultant reasonably acceptable to Landlord and proceed to
Clean-Up such Hazardous Substances in accordance with all applicable laws and as required by such plan and this Lease. If, within thirty (30) days after receiving a copy of such Environmental Report,
Tenant fails either (a) to complete such Clean-up, or (b) with respect to any Clean-up that cannot be completed within such
30-day period, fails to proceed with diligence to prepare the Clean-up plan and complete the Clean-up as required herein as
promptly as practicable, then Landlord shall have the right, but not the obligation, and without waiving any other rights under this Lease, to carry out any Clean-up recommended by the Environmental Report or
required by any governmental authority having jurisdiction over the Premises, and recover all of the costs and expenses thereof from Tenant as Additional Rent, payable within ten (10) days after receipt of written demand therefor. 

7.6.6.2    No Rent Abatement. Tenant shall continue to pay all Rent due or
accruing under this Lease during any Clean-up required to be performed by Tenant under Section 7.6.6.1, and Tenant shall not be entitled to any reduction, offset or deferral of any
Base Rent or Additional Rent due or accruing under this Lease during any such Clean-up. 

7.6.6.3    Surrender of Premises. Tenant shall complete any Clean-up required to be performed by Tenant under Section 7.6.6.1 prior to surrender of the Premises upon the expiration or earlier termination of this Lease, and shall fully comply with
all Environmental Laws and requirements of any governmental authority with respect to such completion, including, without limitation, fully comply with any requirement to file a risk assessment, mitigation plan or other information with any such
governmental authority in conjunction with such Clean-up prior to such surrender. Tenant shall obtain and deliver to Landlord a letter or other written determination from the overseeing governmental authority
confirming that the Clean-up has been completed in accordance with all requirements of such governmental authority and that no further response action of any kind is required for the unrestricted use of the
Premises (“Closure Letter”), but only to the extent that the applicable governmental authority issues Closure Letters with respect to the applicable Clean-up. Upon the
expiration or earlier termination of this Lease, Tenant shall also be obligated to close all permits obtained in connection with Hazardous Substances in accordance with Applicable Laws. 

7.6.6.4    Failure to Timely Clean-Up.
Should any Clean-up for which Tenant is responsible not be completed, or should Tenant not receive the Closure Letter and any governmental approvals required under Environmental Laws in conjunction with
such Clean-up prior to the expiration or earlier termination of this Lease, and Tenant’s failure to receive the Closure Letter is prohibiting Landlord from leasing the Premises or any part thereof to a
third party, or prevents the occupancy or use of the Premises or any part thereof by a third party, then Tenant shall be liable to Landlord as a holdover tenant (as more particularly provided in Section 2.2) until Tenant
has fully complied with its obligations under this Section 7.6. 

  
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 7.6.7    Confidentiality. Unless required to
do so by applicable law, Tenant agrees that Tenant shall not disclose, discuss, disseminate or copy any information, data, findings, communications, conclusions and reports regarding any Release or the status of compliance of the Premises with
Environmental Laws to any Person (other than Tenant’s consultants, attorneys, property managers and employees that have a need to know such information), including any governmental authority, without the prior written consent of Landlord. In
the event Tenant reasonably believes that disclosure is required by Applicable Laws, it shall provide Landlord ten (10) days’ advance notice of disclosure of the applicable confidential information so that Landlord may attempt to obtain a
protective order. Tenant may additionally disclose any such information to bona fide prospective purchasers or lenders, subject to any such parties’ written agreement to be bound by the terms of this Section 7.6. 

7.6.8    Copies of Environmental Reports. Within ten (10) days following Landlord’s
request therefor, including without limitation with respect to a Release that is not caused by a Tenant Party, or in any event in connection with any Release caused by a Tenant Party (without any obligation for Landlord to make a request therefor),
Tenant shall provide Landlord with a copy of any and all environmental assessments, audits, studies and reports regarding Tenant’s activities with respect to the Premises, or ground water beneath the Land, or the environmental condition or Clean-up thereof. Tenant shall be obligated to provide Landlord with a copy of such materials without regard to whether such materials are generated by Tenant or prepared for Tenant, or how Tenant comes into
possession of such materials. 
 7.6.9    Signs, Response Plans, Etc. Tenant shall be
responsible for posting on the Premises any signs required under applicable Environmental Laws. Tenant shall also complete and file any business response plans or inventories required by any applicable Environmental Laws with respect to Tenant or
any Tenant Party’s use of the Premises. Tenant shall concurrently file a copy of any such business response plan or inventory with Landlord. 

7.6.10    Survival. Each covenant, agreement, representation, warranty and indemnification
made by Landlord or Tenant set forth in this Section 7.6 shall survive the expiration or earlier termination of this Lease and shall remain effective until all of such obligations under this
Section 7.6 have been completely performed and satisfied. 
 ARTICLE
8    ALTERATIONS, IMPROVEMENTS AND SIGNAGE 
 8.1    Landlord’s
Obligations. Landlord will maintain in good repair (except casualty and condemnation which shall be governed by Article 10 and Article 11, respectively) and in compliance with all Applicable Laws (to the extent
the responsibility of Landlord pursuant to Section 7.3.2, above) (a) all structural components of the Building, including, without limitation, the roof, foundation, exterior and load-bearing walls, and the structural floor slabs; and
(b) the Building Systems (as defined in Section 8.3.1, below) (excluding Building Systems that exclusively serve any portion of the Premises used exclusively for laboratory, research and development, or pilot
production purposes and any Supplemental HVAC Unit (as defined below) installed by Tenant after the date of this Lease). The cost of this maintenance and repair shall be included in Operating Expenses and shall be subject to reimbursement under
Article 5 hereof to the extent provided therein. Subject to Section 9.6, maintenance and repair expenses caused by Tenant’s willful misconduct or negligent acts or omissions shall be paid directly to Landlord by
Tenant in accordance with Section 4.4, and shall not constitute an Operating Expense. 

8.2    Tenant’s Obligations. Tenant shall take good care of the Premises, any Building
Systems that exclusively serve any portion of the Premises used exclusively for laboratory, research and development, or pilot production purposes and any Supplemental HVAC Unit installed by Tenant after the date of this Lease, and, at Tenant’s
cost and expense, shall make all repairs and replacements necessary to maintain the same in as good condition as the same were in on the Commencement Date, ordinary wear and tear, damage due to fire or other casualty (except to the extent the
responsibility of Tenant to restore under this Lease) and damage caused by Landlord or its agents, contractors or employees excepted. Tenant shall maintain all plumbing facilities and electrical fixtures and devices (including replacement when
necessary of all lamps, starters and ballasts) located within the Premises in as good condition as the same were in on the Commencement Date, ordinary wear and tear, damage due to fire or other casualty (except to the extent the responsibility of
Tenant to restore under this Lease) and damage caused by Landlord or its agents, contractors or employees excepted. Subject to Section 9.6, Tenant shall repair, at its cost, all deteriorations or damages to the Property
occasioned by its negligent 

  
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acts or omissions or willful misconduct. If Tenant does not make such repairs required hereunder within twenty (20) days following notice from Landlord, Landlord may, but need not, make such
repairs, and Tenant shall pay the cost thereof as provided in Section 8.7 hereof. 

8.3    Tenant’s Alterations. 

8.3.1    Landlord’s Consent to Alterations. Tenant shall not make or permit any improvements, installations,
alterations or additions (“Alterations”) in or to the Premises, the Building or the Property that involve or affect the structural portions of the Premises or the Property (the “Building
Structure”) or any of the Property’s HVAC, mechanical, electrical, plumbing, life safety or other essential systems or equipment (the “Building Systems”) or the interior walls or
corridors within the Premises without Landlord’s prior written consent, which consent shall not be unreasonably withheld, conditioned or delayed, provided it shall be deemed reasonable for Landlord to withhold its consent to any Alteration
which adversely affects the structural portions or the systems or equipment of the Building or is visible from the exterior of the Building, or which would violate any certificate of occupancy for the Building or any other permits or licenses
relating to the Building. Landlord’s prior written consent shall not be required for minor decorations and customary cosmetic wall and floor coverings in the Premises that are not visible from the exterior of the Building and do not affect the
Building Structure or the Building Systems, for which Tenant provides advance notice to Landlord and which do not exceed $50,000.00 in the aggregate on an annual basis (“Permitted Cosmetic Alterations”).

 8.3.2    Construction Standards. All Alterations made by or on behalf of Tenant shall be made
and performed: (a) by contractors or mechanics approved by Landlord, which approval shall not be unreasonably withheld, conditioned or delayed, who shall carry liability insurance of a type and in such amounts as Landlord shall reasonably
require, naming Landlord and Tenant as additional insureds, (b) in a good and workmanlike manner, (c) so that same shall be at least equal in quality, value, and utility to the original work or installation and shall be in conformity with
Landlord’s building standard specifications, as the same may be amended by Landlord and in effect at such time, (d) in accordance with all Applicable Laws, and (e) except for Permitted Cosmetic Alterations, pursuant to plans, drawings
and specifications (“Tenant’s Plans”) which have been reviewed and approved by Landlord prior to the commencement thereof, which approval shall not be unreasonably withheld, conditioned or delayed,
and have been filed with all applicable governmental authorities. 
 8.3.4    Security System.
Subject to Tenant’s compliance with the provisions of Subsection 6.5.2 and Subsection 8.3.2 above, to the extent applicable as provided herein, Tenant shall have the right to install, at its expense, a security system to secure
the Premises provided that Landlord is given access cards or passwords as required to permit Landlord to enter the Premises (but not any Secure Areas) in accordance with this Lease. 

8.4    Tenant’s Property. Except as otherwise provided in the last sentence of
Section 8.5, all trade fixtures, furnishings, equipment and personal property placed in the Premises by Tenant and all computer, telecommunications or other cabling and wiring installed in the Premises or elsewhere at the
Property by or for the benefit of Tenant (collectively, the “Tenant’s Property”) shall be removed by Tenant at the expiration of the Term. Tenant shall, at its cost and expense, repair any damage to the Premises
or the Property caused by such removal. Any of Tenant’s Property not removed from the Premises prior to the Expiration Date shall, at Landlord’s option, become the property of Landlord. Except as otherwise provided in the last sentence of
Section 8.5, Landlord may remove such Tenant’s Property, and Tenant shall pay to Landlord, Landlord’s cost of removal and of any repairs in connection therewith in accordance with
Section 4.4 hereof. 
 8.5    Ownership and Removal. All
additions, fixtures and improvements attached to or installed in or upon the Premises by Tenant or by Landlord shall be Landlord’s property and shall remain upon the Premises at the termination of this Lease without compensation or allowance or
credit to Tenant. Landlord may require at the time of Landlord consent that Tenant, at Tenant’s expense, remove any Alterations that have been attached to or installed in the Premises and if Tenant fails to do so, then Landlord may remove the
same and, Tenant shall pay to Landlord the cost of such removal and of any repairs for any damage to the Premises or Property in connection therewith. Notwithstanding the foregoing to the contrary, Tenant shall have no obligation to remove
(i) any Alterations made under this Lease unless Landlord has conditioned its approval of the same upon such removal at the time it approved Tenant’s final plans and specifications for such Alterations, and Landlord has not thereafter

  
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rescinded such removal requirement by written notice to Tenant; provided, however, that Tenant shall be required in all events to remove any internal stairwells, private bathrooms and showers,
raised floors, Supplemental HVAC Unit, specialized fire suppression systems, kitchens, bathrooms and showers, and any structural improvements made by Tenant following the Commencement Date as Alterations unless otherwise agreed by Landlord in
writing; or (ii) any Alterations existing as of the Commencement Date. Notwithstanding anything in this Lease to the contrary, the equipment described on Exhibit 8.5, attached, shall remain in the Premises or may be removed from the
Premises at the expiration or earlier termination of the Term as set forth in such Exhibit 8.5. 

8.6    Surrender of Premises: Environmental Assessment. 

8.6.1    Surrender of Premises. Upon the expiration or sooner termination of the Term, Tenant will quietly and
peacefully surrender to Landlord the Premises in as good condition as when Tenant took possession, ordinary wear and tear, damage caused by Landlord or any Landlord Party, and damage by fire or other casualty excepted, and otherwise as is required
in Section 8.6.2. For purposes of clarification, in connection with any such surrender, Tenant shall have no obligation to undertake work or construction necessary to cause the Premises to comply with Applicable Laws that
existed as of the Commencement Date unless (a) Tenant has received a notice of violation with respect thereto subsequent to the Commencement Date from a governmental authority having jurisdiction over the Premises, (b) any such non-compliance results from Tenant’s (or any Tenant Party’s) acts or omissions after the Commencement Date, or (c) as may otherwise be required to comply with Section 8.6.2. 

8.6.2    Environmental Assessment. Prior to the expiration of this Lease (or within thirty (30) days after any
earlier termination), Tenant shall clean and otherwise decommission all interior surfaces (including floors, walls, ceilings, and counters), piping, supply lines, waste lines and plumbing in or serving the Premises, and all exhaust or other ductwork
in or serving the Premises, in each case that has carried, released or otherwise been exposed to any Hazardous Substances due to Tenant’s use or occupancy of the Premises, and shall otherwise clean the Premises so as to permit the Environmental
Assessment called for by this Section 8.6.2 to be issued. Prior to the expiration of this Lease (or within thirty (30) days after any earlier termination), Tenant, at Tenant’s expense, shall obtain for Landlord an
Environmental Assessment addressed to Landlord (and, at Tenant’s election, Tenant) by a reputable licensed environmental engineer or industrial hygienist that is designated by Tenant and acceptable to Landlord in Landlord’s reasonable
discretion, which report shall be based on the environmental engineer’s inspection of the Premises and shall state, to Landlord’s reasonable satisfaction, that (a) the Hazardous Substances described in the first sentence of this
paragraph, to the extent, if any, existing prior to such decommissioning, have been removed in accordance with Applicable Laws; (b) all Hazardous Substances described in the first sentence of this paragraph, if any, have been removed in
accordance with Applicable Laws from the interior surfaces of the Premises (including floors, walls, ceilings, and counters), piping, supply lines, waste lines and plumbing, and all such exhaust or other ductwork in the Premises, may be reused by a
subsequent tenant or disposed of in compliance with Applicable Laws without incurring special costs or undertaking special procedures for demolition, disposal, investigation, assessment, cleaning or removal of such Hazardous Substances and without
giving notice in connection with such Hazardous Substances; and (c) the Premises may be reoccupied for office, research and development, or laboratory use, demolished or renovated without incurring special costs or undertaking special
procedures for disposal, investigation, assessment, cleaning or removal of Hazardous Substances described in the first sentence of this paragraph and without giving notice in connection with Hazardous Substances. Further, for purposes of clauses
(b) and (c), “special costs” or “special procedures” shall mean costs or procedures, as the case may be, that would not be incurred but for the nature of the Hazardous Substances as Hazardous Substances instead of non-hazardous materials. The report shall also include reasonable detail concerning the clean-up measures taken, the clean-up
locations, the tests run and the analytic results. Tenant shall submit to Landlord the identity of the applicable consultants and the scope of the proposed Environmental Assessment for Landlord’s reasonable review and approval at least 30 days
prior to commencing the work described therein or at least 60 days prior to the expiration of the Term, whichever is earlier. 
 If Tenant fails to timely
perform its obligations under this Section 8.6.2, without limiting any other right or remedy, Landlord may, on five (5) business days’ prior written notice to Tenant, perform such obligations at Tenant’s expense if Tenant
has not commenced to do so within said five (5) business day period, and Tenant shall within ten (10) days of written demand therefor, reimburse Landlord for all reasonable
out-of-pocket costs and expenses incurred by Landlord in connection with the performance of such obligations. Tenant’s obligations under this
Section 15.2 shall survive the expiration or earlier termination of this 

  
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Lease. In addition, at Landlord’s election, Landlord may inspect the Premises for Hazardous Substances at Landlord’s cost and expense within sixty (60) days of Tenant’s
surrender of the Premises at the expiration or earlier termination of this Lease. Tenant shall pay for all such costs and expenses incurred by Landlord in connection with such inspection if such inspection reveals that a Release or threat of Release
of Hazardous Substances exists at the Premises as a result of the acts or omission of Tenant, its officers, employees, contractors, and agents-, except to the extent resulting from (i) Hazardous Substances existing in the Premises as of the
delivery of possession of the Premises to Tenant, or (ii) the acts or omissions of Landlord or any Landlord Party (in which event Landlord shall be responsible for any Clean-up, as provided in this
Lease). 
 8.7    Tenant’s Failure to Maintain. If Landlord gives Tenant written notice of the
necessity of any repairs or replacements required to be made by Tenant under Section 8.2 and Tenant fails to commence diligently to cure the same within twenty (20) days thereafter (except that no notice will be
required in case of any emergency repair or replacement necessary to prevent substantial damage or deterioration), Landlord, at its option and in addition to any other remedies, may proceed to make such repairs or replacements and the expenses
incurred by Landlord in connection therewith plus five percent (5%) thereof for Landlord’s supervision, shall be due and payable from Tenant in accordance with Section 4.4 hereof, as Additional Rent; provided, that,
Landlord’s making any such repairs or replacements shall not be deemed a waiver of Tenant’s default in failing to make the same. 

8.8    Signs. Except as expressly set forth in this Section 8.8, Tenant shall not place or erect
any signs, monuments or other structures on the exterior of the Building or in Common Areas outside of the Building, nor shall Tenant place any signage on the exterior of the Premises or on the inside of the Premises which are visible from the
exterior of the Premises. Tenant shall pay for all costs to change signage as a result of a change in the name of the business occupying the Premises. 

Notwithstanding the foregoing, Tenant may, at its sole cost and expense, install and maintain signage containing Tenant’s (or any
permitted assignee of Tenant’s) name and corporate logo in areas to be reasonably agreed upon by the parties in the main lobby of the Building (the “Lobby Signage”). If Tenant leases less than 100% of the rentable area of the
Building, Tenant shall be permitted to install and maintain only one (1) sign as Lobby Signage. The design, proportions and color of the Lobby Signage shall be subject to Landlord’s prior approval, not to be unreasonably withheld,
conditioned or delayed. Tenant’s rights to such Lobby Signage shall be exclusive for so long as Tenant leases at least 85% of the rentable floor area of the Building, and if Tenant leases less than 85% of the rentable floor area of the
Building, Landlord shall provide Tenant, at Tenant’s expense, with non-exclusive building-standard lobby and elevator directory signage and suite entry signage. 

For so long as (i) Tenant leases at least 85% of the rentable floor area of the Building, and (ii) Tenant has neither assigned this
Lease nor sublet more than 50% of the rentable floor area of the Premises except for Permitted Transfers (the “Exterior Signage Occupancy Requirements”), Tenant shall be permitted, at Tenant’s sole cost and expense, to erect
one (1) sign on the exterior façade of the Building facing Crosby Drive (the “Façade Sign”) and up to four (4) plaques on the exterior of the Building (“Exterior Plaques”) at the entrance to the
Premises. The Façade Sign shall contain Tenant’s name and logo (or the name and logo of any permitted assignee of Tenant) and shall be in a location reasonably approved by Landlord, which approval will not be unreasonably withheld. The
Exterior Plaques may contain Tenant’s name and logo or the name and logo of any Permitted Occupant and shall be in a location reasonably approved by Landlord, which approval will not be unreasonably withheld. Tenant’s right to erect the
Façade Sign shall be exclusive so long as Tenant meets the Exterior Signage Occupancy Requirements. At such time as Tenant no longer meets the Exterior Signage Occupancy Requirements, Landlord may permit other Building tenants to install a
façade sign on the Building exterior. At such time as Tenant leases less than 100% of the rentable floor area of the Building, Tenant shall be permitted to maintain only one (1) Exterior Plaque on the Building exterior, and Tenant’s
right to maintain Exterior Plaques on the Building exterior shall not be exclusive (i.e., Landlord may permit other building tenants to install Exterior Plaques at the entrance to the Building). 

The design, size, proportions and color of all signage described in this Section 8.8 shall be subject to the prior
approval of Landlord (which approval shall not be unreasonably withheld, conditioned or delayed) and shall further be subject to the requirements of the Town of Bedford Zoning By-Law and any other Applicable
Laws and to Tenant obtaining all necessary permits and approvals therefor. 

  
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 Tenant acknowledges and agrees that, except as otherwise provided in this
Section 8.8, Tenant’s right to signage is not on an exclusive basis and Landlord may grant other tenants at the Property the right to maintain signage at the Property. 

In the event that at any time during the Term Tenant ceases to meet the applicable occupancy thresholds described above, Tenant shall, upon
Landlord’s written request and at Tenant’s sole cost and expense, remove all or any portion of the Tenant’s signage described in this Section 8.8 and designated by Landlord for removal and restore any areas
affected by the installation and subsequent removal of Tenant’s signage. In addition, Tenant shall be required at its sole cost and expense to remove all of Tenant’s signage described in this Section 8.8 and
restore any areas affected by the installation and subsequent removal of Tenant’s signage upon the expiration or earlier termination of the Term. 

The provisions of this paragraph are personal to the originally named Tenant and any permitted Transferees. If the Façade Sign or any
Exterior Plaque requires municipal or other governmental approval, and such approval is denied, Landlord shall not be deemed to be in default hereunder and this Lease shall continue in full force and effect. Landlord shall have the right to relocate
the Façade Sign and/or any Exterior Plaque on a temporary basis in connection with the maintenance and repair of the Building. Notwithstanding anything contained herein, Landlord agrees that, so long as Tenant leases 85% of the rentable floor
area of the Building, Tenant shall have the right to prohibit any sign (other than Tenant’s) from being placed on the roof of or on the exterior façade of the Building (with the exception of signage identifying the Building address and any
other sign required by Applicable Laws). 
 ARTICLE 9    INSURANCE 

9.1    Tenant’s Insurance. Tenant, at its own expense, shall provide and keep in force with companies
which are rated A/XV or better by A.M. Best Company and licensed in the Commonwealth of Massachusetts: (a) combined single limit commercial general liability insurance insuring against liability for personal injury and property damage,
including contractual liability, in the amount of $2,000,000.00 per occurrence/$5,000,000.00 annual aggregate limit which may be achieved through a combination of General Liability and umbrella insurance (provided that any umbrella coverage is on a
‘following-form’ basis); (b) “Special Form” property insurance, including standard fire and extended coverage insurance, in amounts necessary to provide replacement cost coverage, for Tenant’s Property, machinery, electronic
data and any Alterations in which Tenant has an insurable property interest, including, without limitation, vandalism and malicious mischief and sprinkler leakage coverage, and “all risk” Builder’s Risk insurance, completed value, non-reporting form at any time that Tenant has commenced construction of any leasehold improvements or any Alterations, and at any time any other construction activities are underway at the Premises; (c) plate
glass insurance for the Premises (if applicable); (d) Workers’ Compensation Insurance in statutory limits as required by applicable law; and (e) any other insurance reasonably required by Landlord. At Landlord’s request, the amounts
and kinds of insurance coverages described herein may be reasonably increased or expanded to reflect amounts and coverages then typically being carried for similar business operations in institutionally owned or financed properties in the Route 128
corridor between Bedford and Newton, Massachusetts. 
 9.2    Policies. Each such insurance policy shall:
(a) be provided in form, substance and amounts (where not above stated) reasonably satisfactory to Landlord and to Landlord’s Mortgagee; (b) specifically include the liability assumed hereunder by Tenant to the extent applicable for
such policy (provided that the amount of such insurance shall not be construed to limit the liability of Tenant hereunder); (c) shall provide that it is primary insurance, and not excess over or contributory with any other valid, existing and
applicable insurance in force for or on behalf of Landlord; and (d) provide that the insurer will give Landlord twenty (20) days’ written notice prior to any cancellation (except in the event of cancellation for non-payment of premium for which ten (10) days’ prior written notice will be given). Tenant shall deliver either policies of such insurance or certificates of the insurance policies, as Tenant may elect,
required to be maintained by Tenant hereunder to Landlord on or before the Commencement Date, and, thereafter, before the expiration dates of expiring policies. All such certificates for liability insurance shall provide that Landlord, its
Mortgagees and Landlord’s managing agent shall each be named as an additional insured. In the event Tenant shall fail to procure such insurance, or to timely deliver such certificates, Landlord may, at its option, procure same for the account
of Tenant, and the cost thereof shall be paid to Landlord as Additional Rent within five (5) days after delivery to Tenant of bills therefor. Tenant’s compliance with the provisions of this Article 9 shall in no way limit
Tenant’s liability under any of the other provisions of this Lease. 

  
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 9.3    Increased Insurance Risk. Tenant shall not do or
permit anything to be done, or keep or permit anything to be kept in the Premises, which would: (a) be in violation of any governmental law, regulation or requirement, (b) invalidate or be in conflict with the provision of any fire or
other insurance policies covering the Property or any property located therein, (c) result in a refusal by fire insurance companies of good standing to insure the Property or any such property in amounts required by a Mortgagee or reasonably
satisfactory to Landlord, or (d) cause any increase in the fire insurance rates applicable to the Property or property located therein at the beginning of the Term or at any time thereafter. In the event that any use of the Premises by Tenant
increases such cost of insurance, Landlord shall give Tenant written notice of such increase (including reasonable evidence of such increase and the cause thereof) and a reasonable opportunity to change its use to prevent such increase; provided,
however, if Tenant fails to do so, Tenant shall pay such increased cost to Landlord in accordance with Section 4.4 hereof. Acceptance of such payment shall not be construed as a consent by Landlord to Tenant’s such use, or limit
Landlord’s remedies under this Lease. 
 9.4    Indemnity. (a) Subject to the provisions of
Section 9.6.1, Tenant shall defend with counsel approved by Landlord in Landlord’s reasonable discretion, indemnify and hold harmless Landlord, all employees, officers, directors, partners, members and shareholders of
Landlord, Mortgagees of the Property and any other party having an interest therein from and against any and all liabilities, losses, damages, costs, expenses (including reasonable attorneys’ fees and expenses), causes of action, suits, claims,
demands or judgments of any nature arising from or out of (a) any injury to or death of any person or damage to or loss of property during the Term, or any period Tenant is in possession of the Premises, in or on the Premises or connected with
the use, condition or occupancy of Premises, except to the extent caused by the negligence or willful misconduct of Landlord or any employee, agent or contractor of Landlord, (b) any breach or violation by Tenant of any of the terms, conditions
or provisions of this Lease, (c) any act, omission, fault, misconduct, negligence or violation of applicable laws and regulations by Tenant or any Tenant Parties, or (d) any construction or other work by Tenant on or about the Premises
pursuant to Article 8 or otherwise, except to the extent caused by the neligence or willful misconduct of Landlord or any employee, agent or contractor of Landlord. 

(b) Subject to the provisions of Section 9.6.1, Landlord shall defend with counsel approved by Tenant, indemnify and hold harmless
Tenant, all employees, officers, directors, partners, members and shareholders of Tenant from and against any and all liabilities, losses, damages, costs, expenses (including reasonable attorneys’ fees and expenses), causes of action, suits,
claims, demands or judgments of any nature arising from or with respect to any injury to or death of any person or damage to or loss of property to the extent the same shall arise out of the negligence or willful misconduct of Landlord or any
employee, agent or contractor of Landlord. Notwithstanding the foregoing, Landlord’s indemnity under this Section 9.4 shall not apply to the extent any such liabilities, losses, damages, costs, expenses (including
reasonable attorneys’ fees and expenses), causes of action, suits, claims, demands or judgments shall arise out of Tenant’s negligence or willful misconduct. 

9.5    Tenant’s Use and Occupancy. Tenant’s use and occupancy of the Premises and the Property and
the use thereof by all Tenant Parties, and all Tenant’s and said parties’ furnishings, fixtures, equipment, improvements, materials, supplies, inventory, effects and property of every kind, nature and description which, during the
continuance of this Lease or any occupancy of the Premises by Tenant or anyone claiming under Tenant, may be in, on or about the Premises, shall be at Tenant’s and said parties’ sole risk and hazard, except as otherwise expressly provided
in this Lease. To the extent permitted pursuant to Applicable Law, Landlord shall not be liable to Tenant or any other party for injury to or death of any person or damage to or destruction of any property in, on or about the Premises, nor for any
interruption in Tenant’s use of the Premises or the conduct of its business therein, nor for any other losses, damages, costs, expenses or liabilities whatsoever, including without limitation where caused by fire, water, explosion, collapse,
the leakage or bursting of water, steam, or other pipes, any environmental or other condition in, on, or about the Premises, or any other event, occurrence, condition or cause, except as otherwise expressly provided in this Lease and except to the
extent caused by the negligence or willful misconduct of Landlord or any Landlord Party. 
 9.6    Waiver of
Claims; Subrogation Rights. 
 9.6.1    Mutual Waiver. Notwithstanding anything contained
in this Lease to the contrary, Landlord and Tenant hereby agree and hereby waive any and all rights of recovery against each other for loss or damage occurring to the Building or the Property or any of Landlord’s property or Tenant’s
Property contained therein regardless of the cause of such loss or damage to the extent 

  
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that the loss or damage is covered by the injured party’s insurance or the insurance the injured party is required to carry under this Lease, whichever is greater (without regard to any
deductible provision in any policy). This waiver also applies to each party’s directors, officers, employees, shareholders, and agents. 

9.6.2    Insurance Policy Coverage. Each party will assure that its insurance permits waiver of
liability and contains a waiver of subrogation. Each party shall secure an appropriate clause in, or an endorsement to, each insurance policy obtained by or required to be obtained by Landlord or Tenant, as the case may be, under this Lease,
pursuant to which the insurance company: (a) waives any right of subrogation against Landlord or Tenant as the same may be applicable, or (b) permits Landlord or Tenant, prior to any loss to agree to waive any claim it might have against
the other without invalidating the coverage under the insurance policy. If, at any time, the insurance carrier of either party refuses to write (and no other insurance carrier licensed in Massachusetts will write) insurance policies which consent to
or permit such release of liability, then such party shall notify the other party and upon the giving of such notice, this Section 9.6.2 shall be void and of no effect. 

9.7    Landlord’s Insurance. At all times during the Term, Landlord shall
maintain so-called All-Risk property insurance on the Building at replacement cost. In addition, at all times during the Term, Landlord shall maintain Commercial General
Liability insurance applicable to the Property, the Building and the Common Areas, providing, on an occurrence basis, a minimum combined single limit of at least $5,000,000.00. 

ARTICLE 10    CASUALTY 

10.1    Damage or Destruction. 

10.1.1    Landlord’s Repair Obligation. Tenant shall give prompt notice to Landlord of any
damage by fire or other casualty (a “Casualty”) to the Building or any portion thereof. During the thirty (30)-day period following the occurrence of a Casualty (the
“Notice Period”), Landlord will notify Tenant of Landlord’s reasonable, good faith estimate (the “Landlord’s Estimate”) of the period of time required to complete the
restoration work with respect to such Casualty. In the event that the Building or any part thereof or material access thereto shall be damaged or destroyed by a Casualty, and if in the reasonable, good faith judgment of Landlord the restoration work
with respect to such Casualty can be completed with available insurance proceeds within two hundred forty (240) days of adjustment of the insurance claim, then Landlord shall so notify Tenant and shall complete the restoration work as provided
in Section 10.4 hereof with reasonable diligence, subject to the limitations, if any, of Applicable Laws. If, in the reasonable judgment of Landlord, the restoration work with respect to a Casualty cannot be completed with
available insurance proceeds within two hundred forty (240) days after adjustment of the insurance claim, then either party shall have the right to terminate this Lease by giving written notice of such termination to the other party within the
thirty (30) days after Landlord has provided Landlord’s Estimate to Tenant. If the restoration period estimated by Landlord is more than two hundred forty (240) days and neither party terminates this Lease on account thereof in
accordance with the foregoing provisions of this Section 10.1.1, Landlord shall complete such restoration work as provided in Section 10.4 hereof with reasonable diligence, subject to the
limitations, if any, of Applicable Laws, within the period so estimated by Landlord. 

10.1.2    Failure to Complete Repairs: Rights of Termination. If Landlord is obligated, or elects,
to perform the restoration work and fails to substantially complete the restoration work within the longer of the period of time required or permitted by this Section 10.1 or the time set forth in Landlord’s Estimate
plus a contingency period equal to 10% of the time set forth in Landlord’s Estimate (as the same may be reasonably extended due to any delay caused by Force Majeure) (the “Reconstruction Period”) then,
Tenant shall have the right to terminate this Lease by delivery of written notice to Landlord not later than thirty (30) days following the end of the Reconstruction Period. 

10.2    Abatement of Rent. Base Rent and Additional Rent shall not be abated or suspended if,
following any Casualty, Tenant shall continue to have reasonably convenient access to the entire Premises and no portion of the Premises is rendered unfit for use and occupancy. If Tenant shall not have reasonably convenient access to the Premises
or any portion thereof or any portion of the Premises shall be otherwise rendered unfit for use and occupancy by Tenant for the purposes set forth in 

  
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Section 7.1 by reason of a Casualty, then Rent shall be equitably suspended or abated relative to the portion of the Premises that cannot be used or accessed by Tenant
for its business operations, effective as of the date of the Casualty until Landlord has (a) substantially completed the restoration work and (b) has delivered notice thereof to Tenant. 

10.3    Events of Termination. Notwithstanding the provisions of this Article 10, if,
prior to or during the Term the Property shall be so damaged by Casualty that, in Landlord’s reasonable estimate, the cost to repair the damage will be more than twenty-five percent (25%) of the replacement value of the Building or all of the
buildings located at the Property immediately prior to the occurrence of the Casualty (whether or not the Premises shall have been damaged or rendered untenantable), then, in any of such events, Landlord, may give to Tenant, within sixty
(60) days after such Casualty, a sixty (60) days’ notice of the termination of this Lease and, in the event such notice is given, this Lease and the Term shall terminate upon the expiration of such sixty (60) days with the same
effect as if such date were the Expiration Date. If more than twenty-five percent (25%) of the gross rentable area of the Premises shall be wholly or substantially damaged or destroyed by a Casualty at any time during the last six (6) months of
the Term, either Landlord or Tenant may terminate this Lease by delivery of written notice of such termination to the other party within thirty (30) days after the occurrence of such casualty. 

10.4    Scope of Landlord’s Repairs. In the event Landlord elects or shall be obligated
to repair or restore any damage or destruction to the Premises pursuant to this Article 10, Landlord shall not be obligated to restore or replace Tenant’s Property or Tenant’s Alterations. No damages, compensation or claim shall be
payable by Landlord to Tenant, or any other person, by reason of inconvenience, loss of business or annoyance arising from any damage or destruction, or any repair thereof, as is referred to in this Article 10. 

10.5    Restoration Work. As used in this Article 10, the phrase “restoration
work” with respect to any Casualty shall mean the work required to repair any damage to the Building caused by such Casualty and to restore the Building substantially to the condition the Building was in immediately prior to such Casualty. 

ARTICLE 11    CONDEMNATION 

11.1    Entire Condemnation. In the event that the whole of the Premises or all of the access
thereto shall be taken under the power of eminent domain or by any proceeding for taking for public or quasi-public use (a “Condemnation”), this Lease and the term and estate hereby granted shall automatically
terminate as of the earlier of the date of the vesting of title or the date of dispossession of Tenant as a result of such taking. 

11.2    Partial Condemnation. 

11.2.1    Effect of Partial Condemnation. In the event that only a part of the Premises shall be
taken by Condemnation and the remaining Premises are suitable for the Permitted Uses without material interference with Tenant’s business operations and Tenant shall have reasonable, convenient access to and from the Premises, the Term shall
expire as to that portion of the Premises condemned effective as of the date of the vesting of title in the condemning authority, and this Lease shall continue in full force and effect as to the part of the Premises not so taken. In the event of a
partial Condemnation of the Premises or the Common Areas which results in (i) a lack of reasonable, convenient access to and from the Premises and Landlord is unable to promptly make reasonable alternative arrangement to replace the same,
(ii) insufficient space within the Premises for Tenant to carry on its business without material interference with its business, or (iii) either thirty-three percent (33%) of the parking spaces available for Tenant’s use in accordance
Section 1.3 or all loading dock facilities serving the Building shall be taken, Tenant shall have the right to terminate this Lease. 

11.2.2    Landlord’s Option to Terminate. In the event that a part of the Property shall be
subject to Condemnation (whether or not the Premises are affected), Landlord may, at its option, terminate this Lease as of the date of such vesting of title, by notifying Tenant in writing of such termination within ninety (90) days following
the date on which Landlord shall have received notice of the vesting of title in the condemning authority if in Landlord’s reasonable opinion: (a) a substantial alteration or reconstruction of the Property (or any portion thereof) shall be
necessary or appropriate, or (b) the portion of the Property so condemned has the effect of rendering the remainder of the Property uneconomic to maintain. 

  
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 11.2.3    Landlord’s Repair Obligations. In
the event that this Lease is not terminated in accordance with Subsection 11.2.2 hereof, Landlord shall, upon receipt of the award in condemnation, make all necessary repairs or alterations to the Building so as to constitute the remaining
Premises a complete architectural unit and make all necessary repairs or alterations to the Common Areas serving the Building to the extent feasible and permitted by Applicable Laws, but Landlord shall not be required to spend for such work an
amount in excess of the amount received by Landlord as damages for the part of the Premises so taken. “Amount received by Landlord” shall mean that part of the award in condemnation which is free and clear to Landlord of any collection by
Mortgagees and after payment of all costs involved in collection, including but not limited to attorney’s fees. Tenant, at its own cost and expense, shall restore the Premises to the condition it is required to be left in at the end of the Term
pursuant to the terms of this Lease. In the event of a partial taking, all provisions of this Lease shall remain in full force and effect, except as otherwise provided in Section 11.5. 

11.3    Temporary Taking. If there is a taking of the Premises for temporary use arising out
of a temporary emergency or other temporary situation, this Lease shall continue in full force and effect, and Tenant shall continue to comply with Tenant’s obligations under this Lease, except to the extent compliance shall be rendered
impossible or impracticable by reason of the taking, and Tenant shall be entitled to the award for its leasehold interest. 

11.4    Condemnation Awards. Except as provided in the preceding Section 11.3,
Landlord shall be entitled to the entire award in any condemnation proceeding or other proceeding for taking for public or quasi-public use, including, without limitation, any award made for the value of the leasehold estate created by this Lease.
No award for any partial or entire taking shall be apportioned, and Tenant hereby assigns to Landlord any award that may be made in such condemnation or other taking, together with any and all rights of Tenant now or hereafter arising in or to same
or any part thereof; provided, however, that nothing contained herein shall be deemed to give Landlord any interest in or to require Tenant to assign to Landlord any award made to Tenant specifically for its relocation expenses or the
taking of Tenant’s Property provided that such award does not diminish or reduce the amount of the award payable to Landlord. 

11.5    Proration. In the event of a Condemnation that does not result in a termination of
this Lease as provided herein, the Base Rent and Tenant’s Share shall be adjusted in proportion to that portion of the Premises or access thereto affected by such Condemnation. 

ARTICLE 12    ASSIGNMENT AND SUBLETTING 

12.1    Assignment and Subletting. Tenant shall not, without the prior written consent of
Landlord, assign, mortgage, encumber or otherwise transfer this Lease or any interest herein directly or indirectly, by operation of law or otherwise, or sublet the Premises or any part thereof, or permit the use or occupancy of the Premises by any
party other than Tenant (any such action, a “Transfer”). If at any time or from time to time during the Term, when no Event of Default has occurred and is continuing, Tenant desires to effect a Transfer, Tenant
shall deliver to Landlord written notice (“Transfer Notice”) setting forth the terms of the proposed Transfer and the identity of the proposed assignee or sublessee (each, a
“Transferee”). Landlord shall not unreasonably withhold or delay its consent to a Transfer, provided that (a) Tenant shall deliver to Landlord prior written notice of such proposed Transfer together with
such related information as Landlord shall reasonably request; (b) no Event of Default under this Lease shall have occurred and be continuing; (c) the proposed Transferee, in the case of an assignment of this Lease or a sublease of 75% or
more of the Premises in the aggregate, shall have a net worth equal to or greater than $7,500,000.00 as demonstrated by audited financial statements or equivalent financial information and shall otherwise have a financial condition reasonably
satisfactory to Landlord and sufficient to meet its obligations under any sublease of less than 75% of the Premises; (d) Tenant shall remain fully liable under this Lease and, following an assignment, the Transferee shall be jointly and
severally liable with Tenant for ail such obligations arising after the effective date of such assignment; (e) due to the identity or business of a proposed assignee or subtenant, such approval would cause Landlord to be in violation of any
covenant or restriction contained in another lease or other agreement affecting space elsewhere in the Property; and (f) in the event of an assignment, such Transferee shall agree directly with Landlord to be bound by all of the obligations of
Tenant hereunder arising after the effective date of such assignment pursuant to an 

  
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assumption agreement reasonably satisfactory to Landlord, including, without limitation, the obligation to pay all Rent and other charges due and owing under this Lease after the effective date
of such assignment Tenant shall deliver to Landlord with the Transfer Notice an acceptable assumption agreement for Tenant’s obligations under this Lease (in the case where the Transfer is a proposed assignment of this Lease) together with all
relevant information reasonably requested by Landlord concerning the proposed Transferee to assist Landlord in making an informed judgment regarding the Transferee’s proposed use of the Premises (which use must be permitted by Applicable Laws),
and the financial responsibility, creditworthiness, reputation, and business experience of the Transferee. Subject to Section 12.6, below, the provisions of this Section 12.1 shall apply to a Transfer (by one or more
Transfers) of a controlling portion of or interest in the stock or partnership or membership interests or other evidences of equity interests of Tenant as if such Transfer were an assignment of this Lease; provided that if equity
interests in Tenant at any time are or become traded on a public stock exchange, the transfer of equity interests in Tenant on a public stock exchange shall not be deemed an assignment within the meaning of this Section 12.1. 

12.2 Landlord’s Options. Landlord shall have the option, exercisable by written notice delivered to Tenant within thirty
(30) days after Landlord’s receipt of a Transfer Notice accompanied by the other information described in Section 12.1, to: (a) permit Tenant to Transfer the Premises; or (b) subject to Section 12.1,
disapprove the Tenant’s Transfer of the Premises and to continue this Lease in full force and effect as to the entire Premises; or (c) if the proposed Transfer is a sublease of less than 25,000 rentable square feet of the Premises (other
than a Permitted Transfer or a Transfer to a Permitted Occupant), terminate this Lease as to the portion of the Premises affected by the Transfer as of the date set forth in Landlord’s notice of exercise of such option, which date shall not be
less than thirty (30) days nor more than ninety (90) days following the giving of such notice; or (d) if the proposed Transfer is an assignment of this Lease or a sublease of 25,000 rentable square feet or more of the Premises (in
either case, other than a Permitted Transfer or a Transfer to a Permitted Occupant), terminate this Lease (a “Recapture”) as of the date set forth in Landlord’s notice of exercise of such option, which date shall
not be less than sixty (60) days nor more than ninety (90) days following the giving of such notice; provided, however, that Tenant may, prior to the delivery of a Transfer Notice, request in writing designating the affected area of the
Premises, identifying the prospective subtenant, and providing such other information as Landlord may reasonably request, whether Landlord will exercise a Recapture of the Premises (a “Recapture Notice”) and Landlord
shall notify Tenant whether it shall Recapture the Premises within ten (10) business days of receipt of the Recapture Notice (or if later, the receipt of such information). If Landlord approves of the proposed Transfer pursuant to
Section 12.1 above, Tenant may enter into the proposed Transfer with such proposed Transferee subject to the following conditions: (i) the Transfer shall be on the same terms set forth in the Transfer Notice; and (ii) no
Transfer shall be valid and no Transferee shall take possession of the Premises until an executed counterpart of the assignment, sublease or other instrument effecting the Transfer (in the form approved by Landlord, which approval shall not be
unreasonably withheld, conditioned or delayed) has been delivered to Landlord pursuant to which the Transferee shall expressly assume all of Tenant’s obligations under this Lease (provided that, for a subtenant, the subtenant’s obligations
shall be governed by the terms of the applicable sublease). If Landlord exercises its option to terminate this Lease (or in the case of a partial sublet to release Tenant with respect to the applicable portion of the Premises), Tenant shall
surrender possession of the Premises or of such portion of the Premises, as the case may be, on the date set forth in Landlord’s notice, and thereafter neither Landlord nor Tenant shall have any further liability with respect thereto. If this
Lease shall be terminated as to a portion of the Premises only, (i) Rent, Tenant’s Share and Tenant’s parking allocation shall be readjusted proportionately according to the ratio that the number of square feet and the portion of the
space surrendered compares to the floor area of Tenant’s Premises during the Term of the proposed sublet, and (ii) Landlord shall be responsible, at Landlord’s cost, for separately demising the terminated portion of the Premises from
the remaining portion of the Premises so as to create a multi-tenant building (Tenant acknowledging that Landlord shall have the right to recapture additional portions of the Premises that, in Landlord’s sole judgment, are necessary or
desirable in order to provide a new tenant of the terminated portion of the Premises with loading dock access, front door access and elevator access, it being reasonable to require bifurcation of the Premises in a way that will meet code and render
the recaptured space marketable). 
 12.3 Additional Conditions. Tenant shall not knowingly offer to make, or
enter into negotiations with respect to, any Transfer to: (a) any tenant of the Property or any entity owned by, or under the common control of, whether directly or indirectly, a tenant in the Property unless there is no competing space then
available for leases therein; or (b) any bona fide prospective tenant with whom Landlord is then negotiating with respect to other space in the Property; or (c) any party which would be of such type, character, or condition as to be
inappropriate as a tenant for the Property. 

 12.4 No Release. Landlord’s consent to a Transfer or any Transfer
permitted without Landlord’s consent shall not release Tenant of Tenant’s obligations under this Lease and this Lease and all of the obligations of Tenant under this Lease shall continue in full force and effect as the obligations of a
principal (and not as the obligations of a guarantor or surety). From and after any assignment of this Lease, the obligations of the Transferee and of the original Tenant named in this Lease which respect to obligations under this Lease that arise
or accrue after the effective date of such assignment shall be joint and several. No acceptance of Rent by Landlord from or recognition in any way of the occupancy of the Premises by a Transferee shall be deemed a consent to such Transfer, or a
release of Tenant from direct and primary liability for the further performance of Tenant’s covenants hereunder. The consent by Landlord to a particular Transfer shall not relieve Tenant from the requirement of obtaining the consent of Landlord
to any further Transfer. Each violation of any of the covenants, agreements, terms or conditions of this Lease, whether by act or omission, by any of Tenant’s permitted Transferees, shall constitute a violation thereof by Tenant. In the event
of default by any Transferee of Tenant or any successor of Tenant in the performance of any of the terms hereof, Landlord may proceed directly against Tenant without the necessity of exhausting remedies against such Transferee or successor. 

12.5 Transfer Profit. Tenant shall pay to Landlord, as Additional Rent, an amount (the “Transfer
Profit”) equal to any rent and other economic consideration received by Tenant as a result of any Transfer (other than Permitted Transfers) which exceeds, in the aggregate: (a) the total of the remaining rent which Tenant is
obligated to pay Landlord under this Lease plus (b) any reasonable tenant fit-up costs, brokerage commissions and attorneys’ fees actually paid by Tenant in connection with such Transfer
amortized on a straight-line basis over the term of the Transfer (specifically excluding moving or relocation costs paid to the Transferee and any rent abatement provided to the Transferee). Tenant shall pay such Transfer Profit to Landlord on a
monthly basis within ten (10) days after receipt thereof, without affecting or reducing any other obligations of Tenant hereunder. Each such payment shall be sent with a detailed statement. Landlord shall have the right to audit Tenant’s
books and records to verify the accuracy of the detailed statement. 
 12.6 Permitted Transfers. Notwithstanding the
above, provided Tenant is not in default of this Lease beyond applicable notice and cure periods, then Tenant shall have the right to assign this Lease or sublet the Premises without Landlord’s consent (a “Permitted
Transfer”), but with no less than ten (10) days’ prior notice to Landlord (unless Tenant’s disclosure of such Transfer is prohibited under a confidentiality agreement to which Tenant is a party, in which event notice
shall be provided to Landlord within ten (10) days following such Transfer), to (i) any person that as of the date of determination and at all times thereafter directly, or indirectly through one or more intermediaries, controls, is
controlled by, or is under common control with Tenant, or (ii) any entity into or with which Tenant is merged or consolidated, or to which all or substantially all of Tenant’s assets are transferred (any of the foregoing, an
“Affiliated Company”); provided, however, that in any such event: (w) use of the Premises shall be for the Permitted Use; (x) the assignee shall have a net worth that is equal to or in excess of
the net worth of the original Tenant as of the date of execution of this Lease, and Landlord has been provided with financial statements or evidence otherwise reasonably satisfactory to Landlord of the same; (y) any such assignment shall be for
an independent business purpose and not a means to circumvent the provisions of this Article 12, and (z) the purpose or result of such Transfer shall not be to liquidate or substantially reduce the net worth of Tenant or such assignee.
For the purposes of this Section 12.6, the term “control” shall mean the direct or indirect ownership of 50% or more of an entity and the ability to control the
day-to-day operations of such entity whether through the board of directors or otherwise. 

12.7 Permitted Occupants. Notwithstanding the above, Tenant shall have the right, without the consent of Landlord (but
upon reasonable prior to notice to Landlord), to permit the use or occupancy of a portion of the Premises that is not separately demised and consists of not more than 5,000 rentable square feet of the Premises in the aggregate by license for periods
of less than one (1) year at a time, by persons who have an ongoing contractual or other business relationship with Tenant in connection with Tenant’s activities at the Premises such that such occupants have a reasonable need to work in
proximity with Tenant (each, a “Permitted Occupant” and, collectively, the “Permitted Occupants”); provided that (a) the Permitted Occupants shall use the Premises in conformity with
all applicable provisions of this Lease; (b) such occupancy shall terminate automatically upon the expiration or earlier termination of this Lease; (c) Tenant shall remain fully liable for the acts or omissions of the Permitted Occupants
in the Premises and at the Property; (d) the occupancy arrangement is for a legitimate business objective of 

 
Tenant and is not primarily for the purpose of circumventing the restrictions on assignment and subletting contained herein; (e) all notices required of Landlord under this Lease shall be
forwarded only to Tenant in accordance with the terms of this Lease and in no event shall Landlord be required to send any notices to any Permitted Occupants; (f) in no event shall any use or occupancy of any portion of the Premises by any
Permitted Occupants release or relieve Tenant from any of its obligations under this Lease; (g) the Permitted Occupants and their employees, contractors and invitees visiting or occupying space in the Premises shall be deemed to be Tenant
Parties for purposes of Tenant’s indemnification obligations in Section 9.4; and (h) in no event shall the occupancy of any portion of the Premises by Permitted Occupants be deemed to create a landlord/tenant relationship
between Landlord and such Permitted Occupants or an interest in real property, and, in all instances, Tenant shall be considered the sole tenant under this Lease notwithstanding the occupancy of any portion of the Premises by the Permitted
Occupants. 
 ARTICLE 13 DEFAULTS AND REMEDIES 

13.1 Events of Default. The occurrence of any one or more of the following events shall constitute an event of default
(each an “Event of Default”) hereunder: 
 13.1.1 Nonpayment of Base Rent or Additional Rent.
Failure by Tenant to pay any installment of Base Rent, Additional Rent or any other amount, deposit, reimbursement or sum due and payable hereunder, upon the date when said payment is due hereunder, and such failure to pay such Rent shall continue
for more than five (5) days after the giving of written notice to Tenant from Landlord specifying the amount of unpaid Rent; provided, however, that Landlord shall only be required to give Tenant one (1) written notice with respect to
Tenant’s non-payment on a due date during any twelve (12) month period, and, thereafter, upon the second late payment during any twelve (12) month period, no written notice need be again given
by Landlord to Tenant during such period. 
 13.1.2 Certain Obligations. Failure by Tenant to perform, observe or
comply with any material non-monetary obligation contained in Section 4.6 (“Security Deposit”), Section 7.5 (“No Liens”)
and Article 12 (“Assignment and Subletting”) of this Lease. 
 13.1.3 Other
Obligations. Failure by Tenant to perform any non-monetary obligation, agreement or covenant under this Lease other than those matters specified in Subsection 13.1.2, and such failure continues for
thirty (30) days after written notice by Landlord to Tenant of such failure; provided, however, that if the nature of Tenant’s obligation is such that more than thirty (30) days are required for performance, then Tenant
shall not be in default if Tenant commences performance within such thirty (30)-day period and thereafter diligently and continuously prosecutes the same to completion within one hundred eighty (180) days
following the date of Landlord’s written notice with respect to such failure. 
 13.1.4 Assignment; Receivership;
Attachment. (a) The making by Tenant of any arrangement or assignment for the benefit of creditors; (b) the appointment of a trustee or receiver to take possession of substantially all of Tenant’s assets located at the Premises or
of Tenant’s interest in this Lease, where possession is not restored to Tenant within sixty (60) days; or (iii) the attachment, execution, or other judicial seizure of substantially all of Tenant’s assets located at the Premises
or of Tenant’s interest in this Lease, where such seizure is not discharged within sixty (60) days. 
 13.1.5
Bankruptcy. The admission by Tenant or Tenant’s guarantor (if any) in writing of its inability to pay its debts as they become due, the filing by Tenant or Tenant’s guarantor (if any) of a petition in bankruptcy seeking any
reorganization, arrangement, composition, readjustment, liquidation, dissolution or similar relief under any present or future statute, law or regulation, the filing by Tenant or Tenant’s guarantor (if any) of an answer admitting or failing
timely to contest a material allegation of a petition filed against Tenant or Tenant’s guarantor (if any) in any such proceeding or, if within sixty (60) days after the commencement of any proceeding against Tenant or Tenant’s
guarantor (if any) seeking any involuntary reorganization, or arrangement, composition, readjustment, liquidation, dissolution or similar relief under any present or future statute, law or regulation by any of Tenant’s creditors or such
guarantor’s creditors, such proceeding shall not have been dismissed. 

 13.1.6 Abandonment. Abandonment of the Premises by Tenant for a
continuous period in excess of thirty (30) days. 
 13.2 Remedies. If an Event of Default occurs and Landlord has
not accepted a cure of such Event of Default in writing, Landlord shall have the following rights and remedies, in addition to any and all other rights or remedies available to Landlord in law or equity: 

13.2.1 Notice to Quit. Landlord shall have the right to deliver written notice to Tenant to quit possession and
occupancy of the Premises and to declare this Lease terminated. Upon Landlord’s termination of this Lease, Tenant shall quit and peaceably surrender the Premises, and all portions thereof, to Landlord, and Landlord shall have the right to
receive all rental and other income of and from the same. At Landlord’s election, any written notice of default may also be designated a notice to quit (provided that nothing in this sentence shall be deemed to deny Tenant the right to
applicable cure periods set forth in Section 13.1, above). 
 13.2.2 Right of
Re-Entry. Landlord shall have the right, with or without terminating this Lease, to re-enter the Premises and take possession thereof by summary proceeding,
eviction, ejectment or otherwise and may dispossess all other persons and property from the Premises. Tenant’s property may be removed and stored in a public warehouse or elsewhere at the cost of and for the account of Tenant. No re-entry or taking possession of the Premises by Landlord pursuant to this Subsection 13.2.2 shall be construed as an election to terminate this Lease unless a written notice of such intention is given to
Tenant or unless the termination thereof is decreed by a court of competent jurisdiction. Tenant thereby waives all statutory rights, including without limitation the right to a notice to quit, notice before exercise of any prejudgment remedy, and
any rights of redemption, all to the extent such rights may be lawfully waived. 
 13.2.3 Recovery of Rent and
Damages. Landlord shall have the right to recover from Tenant all loss of Rent and other payments that Landlord may incur by reason of termination of the Lease, including, without limitation: (a) all Rent and other sums due and payable by
Tenant as of the date of termination; (b) all Rent that would otherwise be payable for the remainder of the Term in accordance with the terms of this Lease, as and when due, and Tenant shall indemnify Landlord for the same; (c) all of
Landlord’s then unamortized costs of special inducements provided to Tenant (including without limitation any rent concessions, tenant construction allowances, rent waivers, above building standard leasehold improvements, and the like, if any);
(d) the costs of collecting amounts due from Tenant under this Lease and the costs of recovering possession of the Premises (including attorneys fees and litigation costs); (e) the costs of curing Tenant’s defaults existing at or prior to the
date of termination; (f) all “Reletting Expenses” (as defined below); and (g) all Landlord’s other reasonable expenditures arising from the termination. Tenant shall reimburse Landlord for all such
items, and the same shall be due and payable immediately from time to time upon notice from Landlord that an expense has been incurred, without regard to whether the expense was incurred before or after the termination. Notwithstanding the
foregoing, except as set forth in Section 2.2 of this Lease, Tenant shall not be liable for any of Landlord’s indirect or consequential damages arising from an Event of Default by Tenant. 

13.2.4 Acceleration of Future Rentals. Following termination of this Lease, Landlord, at its written election, shall be
entitled to receive as liquidated damages for all Rent that would otherwise be due and payable pursuant to clause (b) of Subsection 13.2.3, above, an amount equal to: (x) a lump sum payment representing the then present value of the
amount of Rent that would have been paid in accordance with this Lease for the remainder of the Term minus the then present value of the aggregate fair market rent and additional charges payable for the Premises for the remainder of the Term
(if less than the Rent payable hereunder) estimated by Landlord as of the date of termination, and taking into account Landlord’s reasonable projections of vacancy and time required to re-lease the
Premises; or (y) a lump sum payment equal to one year’s Base Rent at the rate applicable under the Lease at the time of such election. Landlord shall be entitled to recover from Tenant, and Tenant shall pay to Landlord, on demand, such
amount as final damages for Tenant’s default with respect to the Rents payable for the remainder of the Term as described above. In the computation of present value, a discount at the then market discount rate as reasonably determined by
Landlord shall be employed. 
 13.2.5 Rents Due After Re-Entry by Landlord. If
Landlord re-enters or otherwise takes possession of the Premises without terminating this Lease (but terminating only Tenant’s right of 

 
possession in the Premises), then this Lease and Tenant’s liabilities and obligations thereunder shall survive such action. In the event of any such termination of Tenant’s right of
possession, whether or not the Premises, or any portion thereof, shall have been relet, Tenant shall pay Landlord a sum equal to the Rent and any other charges required to be paid by Tenant up to the time of such termination of such right of
possession and thereafter Tenant, until the end of the Term, shall be liable to Landlord for and shall pay to Landlord: (a) the equivalent of the amount of the Rent payable under this Lease, less (b) the net proceeds of any
reletting effected pursuant to the provisions hereof after deducting all of Landlord’s Reletting Expenses. Tenant shall pay such amounts in accordance with the terms of this Subsection 13.2.5 as set forth in a written statement thereof
from Landlord to Tenant (the “Deficiency”) to Landlord in monthly installments on the days on which the Base Rent is payable under this Lease, and Landlord shall be entitled to recover from Tenant each monthly
installment of the Deficiency as the same shall arise. Tenant shall also pay to Landlord upon demand the costs incurred by Landlord in curing Tenant’s defaults existing at or prior to the date of such termination, the cost of recovering
possession of the Premises and the Reletting Expenses. Tenant agrees that Landlord may file suit to recover any sums that become due under the terms of this Section from time to time, and all reasonable costs and expenses of Landlord, including
attorneys’ fees and costs incurred in connection with such suits shall be payable by Tenant on demand. 
 13.2.6
Certain Terms Defined. For purposes of this Subsection 13.2.6, “Reletting Alterations” shall mean all repairs, changes, improvements, alterations or additions made by Landlord in or to the Premises
to the extent deemed reasonably necessary by Landlord to prepare the Premises for the re-leasing following an Event of Default; and “Reletting Expenses” shall mean the reasonable
expenses paid or incurred by Landlord in connection with any releasing of the Premises following an Event of Default, including, without limitation, marketing expenses, brokerage commissions, attorneys’ fees, the costs of Reletting Alterations,
tenant allowances and other economic concessions provided to the new tenant. 
 13.3 Landlord’s Right to Cure
Defaults. If Tenant shall default in the observance or performance of any condition or covenant on Tenant’s part to be observed or performed under or by virtue of any of the provisions of this Lease, and such default continues
beyond any applicable notice and cure period or Landlord reasonably determines that an emergency exists, Landlord, without being under any obligation to do so and without thereby waiving such default, may, after prior notice (except in the event of
an emergency) remedy such default for the account and at the expense of Tenant. If Landlord makes any expenditures or incurs any obligations for the payment of money in connection therewith, including but not limited to reasonable attorney’s
fees in instituting, prosecuting or defending any action or proceeding, such sums paid or obligation incurred and costs, shall be paid upon demand to Landlord by Tenant as Additional Rent pursuant to Section 4.4 hereof and if not so paid
with interest from its due date until paid at the lesser of eighteen percent (18%) per annum or the maximum legal rate that Landlord may charge Tenant. 

13.4 Disposition of Tenant’s Property. In addition to Landlord’s rights under Section 8.4 hereof,
Landlord shall have the right to handle, remove, discard or store in a commercial warehouse or otherwise, at Tenant’s sole risk and expense, any of Tenant’s Property that is not removed by Tenant at the end of the Term. Landlord shall in
no event be responsible for the value, preservation or safekeeping thereof. Tenant shall pay to Landlord, upon demand, any and all expenses incurred in such removal and all storage charges for such property so long as the same shall be in
Landlord’s possession or under Landlord’s control. 
 13.5 Reletting. In connection with any reletting of the
Premises following an Event of Default, Landlord shall be entitled to grant such rental and economic concessions and other incentives as may be customary for similar space in the Route 128 North submarket. Subject to applicable law, Landlord shall
not be required to accept any tenant offered by Tenant or observe any instruction given by Tenant about such reletting. Notwithstanding anything in this Lease to the contrary, after any termination of this Lease on account of an Event of Default,
Landlord shall use commercially reasonable efforts to relet the Premises on such terms as Landlord may determine, for any term(s), and may grant market concessions or free rent to the extent that Landlord considers reasonably advisable and necessary
to relet the same, and may make such reasonable alterations, repairs and decorations in the Premises as Landlord in its reasonable judgment considers advisable or necessary for the purpose of reletting the Premises. The making of such alterations,
repairs and decorations shall not operate or be construed to release Tenant from liability hereunder as aforesaid. In no event shall Landlord be required to (i) solicit or entertain 

 
negotiations with any other prospective tenant for the Premises until Landlord obtains full and complete possession of the Premises, (ii) relet the Premises before leasing other vacant space
in the Building or to show the Premises on a priority basis, or (iii) lease the Premises for a rental less than the current fair market rent then prevailing for similar office space in comparable buildings. 

13.6 No Accord and Satisfaction. Landlord may collect and receive any rent due from Tenant, and the payment thereof shall
not constitute a waiver of or affect any notice or demand given, suit instituted or judgment obtained by Landlord, or be held to waive, affect, change, modify or alter the rights or remedies that Landlord has against Tenant in equity, at law, or by
virtue of this Lease. No receipt or acceptance by Landlord from Tenant of less than the monthly rent herein stipulated shall be deemed to be other than a partial payment on account for any due and unpaid stipulated rent; no endorsement or statement
on any check or any letter or other writing accompanying any check or payment of rent to Landlord shall be deemed an accord and satisfaction, and Landlord may accept and negotiate such check or payment without prejudice to Landlord’s rights to
(a) recover the remaining balance of such unpaid rent, or (b) pursue any other remedy provided in this Lease. 
 13.7 Claims
in Bankruptcy. Nothing herein shall limit or prejudice the right of Landlord to prove and obtain in proceeding for bankruptcy, insolvency, arrangement or reorganization by reason of the termination of this Lease, an amount equal to
the maximum allowed by any statute or rule of law in effect at the time when, and governing the proceedings in which, the damages are to be proved, whether or not the amount is greater, equal to or less than the amount of the loss or damage that
Landlord has suffered. Without limiting any of the provisions of this Article 13. if pursuant to the Bankruptcy Code, as the same may be amended, Tenant is permitted to assign this Lease in disregard of the restrictions contained in
Article 12. Tenant agrees that adequate assurance of future performance by the assignee permitted under the Bankruptcy Code shall mean the deposit of cash security with Landlord in any amount equal to all Rent payable under this Lease for the
calendar year preceding the year in which such assignment is intended to become effective, which deposit shall be held by Landlord, without interest, for the balance of the term as security for the full and faithful performance of all of the
obligations under this Lease on the part of Tenant yet to be performed. If Tenant receives or is to receive any valuable consideration for such an assignment of this Lease, such consideration, after deducting therefrom (a) the brokerage
commissions, if any, and other expenses reasonably designated by the assignee as paid for the purchase of Tenant’s property in the Premises, shall be and become the sole exclusive property of Landlord and shall be paid over to Landlord directly
by such assignee. In addition, adequate assurance shall mean that any such assignee of this Lease shall have a net worth indicating said assignee’s reasonable ability to pay the Rent, and abide by the terms of this Lease for the remaining
portion thereof applying commercially reasonable standards. 
 13.8 Arbitration. Any dispute arising out of or relating
to Article 5 of this Lease (with respect to the issues expressly stated therein) shall be submitted to and determined in binding arbitration under the Commercial Arbitration Rules of the American Arbitration Association. The arbitration shall
be conducted before and by a single arbitrator selected by the parties. If the parties have not selected an arbitrator within thirty (30) days of written demand for arbitration, the arbitrator shall be selected by the Boston office of the
American Arbitration Association pursuant to the then current rules of that Association on application by either party. The arbitrator shall have authority to fashion such just, equitable and legal relief as he, in his sole discretion, may
determine. The parties agree that the arbitration hearing shall be held within thirty (30) business days following notification to the parties of the appointment of such arbitrator, and that the arbitration proceedings shall be concluded within
thirty (30) business days following the first scheduled arbitration hearing. Each party shall bear all its own expenses of arbitration and shall bear equally the costs and expenses of the arbitrator. All arbitration proceedings shall be
conducted in the City of Boston, Commonwealth of Massachusetts. Landlord and Tenant further agree that they will faithfully observe this agreement and rules, and that they will abide by and perform any award rendered by the arbitrator and that a
judgment of the court having jurisdiction may be entered upon the award. The duty to arbitrate shall survive the cancellation or termination of this Lease. 

13.9 Waiver of Trial By Jury. TO THE EXTENT PERMITTED BY APPLICABLE LAW, LANDLORD AND TENANT HEREBY WAIVE THE RIGHT TO
TRIAL BY JURY IN ANY ACTION, PROCEEDING OR COUNTERCLAIM, WHETHER IN CONTRACT, TORT OR OTHERWISE, BROUGHT BY EITHER AGAINST THE OTHER ON ANY MATTER WHATSOEVER ARISING OUT OF OR IN ANY WAY CONNECTED WITH THIS LEASE, THE RELATIONSHIP OF LANDLORD AND
TENANT, OR TENANT’S USE OR OCCUPANCY OF THE PREMISES, OR ANY SUMMARY PROCESS, EVICTION OR OTHER STATUTORY REMEDY WITH RESPECT THERETO. EACH PARTY HAS BEEN REPRESENTED BY, AND HAS RECEIVED THE ADVICE OF, LEGAL COUNSEL WITH RESPECT TO THIS
WAIVER. 

 ARTICLE 14 SUBORDINATION; ATTORNMENT AND RIGHTS OF MORTGAGE HOLDERS 

14.1 Subordination. This Lease and all of Tenant’s rights hereunder are, and shall be, subject and subordinate at
all times to the lien of any mortgages or ground leases (each, a “Mortgage”) which may now exist or hereafter affect the Property, or any portion thereof, in any amount, and to all renewals, modifications,
consolidations, replacements, and extensions of such Mortgages. This Section shall be self-operative and no further subordination shall be required. In confirmation of such subordination, Tenant shall promptly execute, acknowledge and deliver any
commercially reasonable instrument that Landlord or the holder of any Mortgage or its assigns or successors in interest (each such holder, a “Mortgagee”) may reasonably request to evidence such subordination, the
parties agreeing that the form attached hereto as Exhibit 14.1 is commercially reasonable. 
 Notwithstanding the foregoing, Landlord
agrees that it shall use commercially reasonable efforts to obtain from its existing Mortgagee for the benefit of Tenant a subordination, non-disturbance and attornment agreement (an
“SNDA”) substantially in the form attached hereto as Exhibit 14.1. Landlord’s failure to obtain any SNDA under this paragraph shall not result in a default under this Lease. 

14.2 Attornment by Tenant. In the event that any such first Mortgage is foreclosed or a conveyance in lieu of foreclosure
is made for any reason, Tenant shall, at the option of the Mortgagee or the grantee or purchaser in foreclosure, notwithstanding any subordination of any such lien to this Lease, attorn to and become the Tenant of the successor in interest to
Landlord. Tenant covenants and agrees to execute and deliver, within ten (10) business days following delivery of request by Landlord, Mortgagee, or by Landlord’s successor in interest and in the form reasonably requested by Landlord,
Mortgagee, or by Landlord’s successor in interest, any additional documents evidencing the priority or subordination of this Lease with respect to the lien of any such first Mortgage, which additional documents shall be satisfactory to Tenant,
Landlord, Mortgagee, and Landlord’s successors in interest. 
 14.3 Limitation of Mortgagees’ Liability.
Notwithstanding any other provision of this Lease to the contrary, no holder of any such Mortgage shall be obligated to perform or liable in damages for failure to perform any of Landlord’s obligations under this Lease unless and until such
holder shall foreclose such mortgage or otherwise acquire title to or succeed to the interest of Landlord in the Building, and then shall only be liable for Landlord’s obligations arising or accruing after such foreclosure, succession or
acquisition of title. No such holder shall ever be obligated to perform or be liable in damages for any of Landlord’s obligations to the extent arising or accruing before such foreclosure or acquisition of title. Such holder’s obligations
and liabilities shall in any event be subject to, and holder shall have the benefit of, Section 16.15 hereof. Tenant shall never pay the Base Rent, Additional Rent or any other charge more than thirty (30) days prior to the due date
thereof, and any payments made by Tenant in violation of this provision shall be a nullity as to such holder, and Tenant shall remain liable to such holder therefor. ant agrees on request of Landlord to execute and deliver from time to time any
reasonable agreement which may be necessary to implement the provisions of this Section 14.3. 
 14.4 Estoppel
Certificates. Tenant shall at any time, and from time to time, upon not less than ten (10) business days prior written notice from Landlord execute, acknowledge and deliver to Landlord, to any prospective purchaser, or Mortgagee,
a written estoppel certificate of Tenant in the form attached as Exhibit 14.4 or any other commercially reasonable form. It is intended that any such certificate of Tenant delivered pursuant to this Section 14.4 may be relied upon
by Landlord and any prospective purchaser or the Mortgagee of any part of the Property. 
 14.5 Quiet Enjoyment.
Provided no Event of Default shall have occurred and be continuing, Tenant may peacefully and quietly enjoy the Premises during the Term as against all persons or entities lawfully claiming by or through Landlord; subject, however, to the
provisions of this Lease. 
 14.6 Mortgagee Approval. Landlord and Tenant hereby agree that this Lease is subject to
the review and approval of Landlord’s Mortgagee in accordance with the terms of the mortgage loan documents executed by Landlord in connection with its financing of the Property. Landlord shall submit this Lease to its Mortgagee promptly upon
Tenant’s execution and delivery of this Lease to Landlord, and Landlord shall promptly advise Tenant of its Mortgagee’s decision. Notwithstanding anything herein to the contrary, if Landlord executes and delivers this Lease to Tenant, then
Landlord’s Mortgagee shall be deemed to have reviewed and approved this Lease. 

 ARTICLE 15 NOTICES 

15.1 Manner of Notice. 

15.1.1 Notices; Addresses. All notices, demands and other communications (“notices”) permitted or
required to be given under this Lease shall be in writing and sent by personal service, certified mail (postage prepaid) return receipt requested or by a nationally recognized overnight courier service to the following addresses or to such other
address as either Landlord or Tenant may designate as its new address for such purpose by notice given to the other in accordance with the provisions of this Section 15.1: 

 

			
	If to Tenant:	  	at the Premises,
		  	Attention: Chief Financial Officer
		
	With copies to:	  	 Nixon Peabody LLP
 100 Summer
Street

		  	Boston, Massachusetts 02110-2131
		  	Attention:   Matthew R. Lynch
		
	If to Landlord:	  	 DIV Bedford, LLC
 c/o The Davis
Companies

		  	 125 High Street, 21st Floor

Boston, MA 02110

		  	Attention:   Cappy Daume
		
	With copies to:	  	 DIV Bedford, LLC
 c/o The Davis
Companies

		  	125 High Street, 21st Floor
		  	Boston, MA 02110
		  	Attention:   General Counsel

 15.1.2 Delivery. Notices shall be deemed to have been given (a) when hand
delivered (provided that delivery shall be evidenced by a receipt executed by or on behalf of the addressee if delivered by personal service) if personal service is used, (b) the sooner of the date of receipt or the date that is three
(3) business days after the date of mailing thereof if sent by postage pre-paid registered or certified mail, return receipt requested, and (d) one (1) business day after being sent by Federal Express or other reputable overnight courier
service (with delivery evidenced by written receipt) if overnight courier service is used. 
 ARTICLE 16 MISCELLANEOUS 

16.1 Brokers. Landlord and Tenant warrant to each other that they have had no dealings with any broker, agent or finder
in connection with this Lease. Both parties hereto agree to protect, indemnify and hold harmless the other from and against any and all expenses with respect to any compensation, commissions and charges claimed by any broker, agent or finder with
respect to this Lease or the negotiation thereof that is made by reason of any action or agreement by such party. 
 16.2 Building
Name. The Building and the Property may be known by such name as Landlord, in its sole discretion, may elect, and Landlord shall have the right from time to time to change such designation or name without Tenant’s consent upon
prior written notice to Tenant. 
 16.3 Authority. Tenant hereby covenants and warrants that Tenant is a duly
authorized and existing entity, that Tenant is duly qualified to do business in Massachusetts, that Tenant has full right and authority to enter into this Lease, and that each person signing on behalf of Tenant is duly authorized to do so and that
no other signatures are necessary. Landlord represents and warrants to Tenant that Landlord possesses fee title to the Property and, upon the approval of Mortgagee pursuant to Section 14.6, above, that it is authorized to enter into this Lease.

 16.4 Interpretation. The words “Landlord” and
“Tenant” as used herein shall include the plural as well as the singular. The words used in neuter gender include the masculine and feminine. If there is more than one Tenant, the obligations under this Lease imposed on Tenant shall be
joint and several. The captions preceding the articles of this Lease have been inserted solely as a matter of convenience and such captions in no way define or limit the scope or intent of any provision of this Lease. This Lease may be executed in
several counterparts and by each party on a separate counterpart, each of which, when so executed and delivered, shall be an original and all of which together shall constitute one instrument. 

16.5 Modifications. Neither this Lease nor any term or provision hereof may be changed, waived, discharged or terminated
orally, and no breach thereof shall be waived, altered or modified, except by a written instrument signed by the party against which the enforcement of the change, waiver, discharge or termination is sought. 

16.6 Severability. If any provision of this Lease or the application thereof to any person or circumstance shall, to any
extent, be invalid or unenforceable, the remainder of this Lease, or the application of such provision to persons or circumstances other than those as to which it is invalid or unenforceable, shall not be affected thereby, and each provision of this
Lease shall be valid and enforceable to the full extent permitted by law. 
 16.7 Entire Agreement. Landlord’s
employees, representatives and agents have no authority to make or agree to make a lease or any other agreement or undertaking in connection herewith. The submission of this document for examination and negotiation does not constitute an offer to
lease, or a reservation of, or option for, the Premises, and this document shall be effective and binding only upon the execution and delivery hereof by both Landlord and Tenant. This Lease, including the Exhibits hereto, which are made part of this
Lease, contain the entire agreement of the parties and all prior negotiations and agreements are merged herein. Neither Landlord nor Landlord’s agents have made any representations or warranties with respect to the Premises, the Building, the
Property, or this Lease except as expressly set forth herein, and no rights, easements or licenses are or shall be acquired by Tenant by implication or otherwise unless expressly set forth herein. 

16.8 No Merger. There shall be no merger of this Lease or of the leasehold estate hereby created with the fee estate in
the Premises or any part thereof by reason of the fact that the same person may acquire or hold, directly or indirectly, this Lease or the leasehold estate hereby created or any interest in this Lease or in such leasehold estate as well as the fee
estate in the leasehold Premises or any interest in such fee estate. 
 16.9 Easements. Landlord reserves the right,
from time to time, to grant easements and rights, make dedications, agree to restrictions and record maps affecting the Property as Landlord may deem necessary or desirable, so long as such easements, rights, dedications, restrictions, and maps do
not unreasonably interfere with the access to or use of the Premises by Tenant; and this Lease shall be subordinate to such instruments. Subject to the provisions of Article 14, above, this Lease is subject and subordinate to all matters of record
now existing or hereafter affecting the Property. Tenant specifically acknowledges that the Property is subject to that certain Notice of Activity and Use Limitation dated October 6, 2011 and recorded at Book 57925, Page 557 of the Middlesex
South Registry of Deeds, the provisions of which are incorporated herein by reference. 
 16.10 Bind and Inure. The
terms, provisions, covenants and conditions contained in this Lease shall bind and inure to the benefit of Landlord and Tenant, and, except as otherwise provided herein, their respective heirs, legal representatives, successors and assigns. If two
or more individuals, corporations, partnerships or other business associations (or any combination of two or more thereof) shall sign this Lease as Tenant, the liability of each such individual, corporation, partnership or other business association
to pay Rent and perform all other obligations hereunder shall be deemed to be joint and several. All agreements, covenants and indemnifications contained herein or made in writing pursuant to the terms of this Lease by or on behalf of Tenant shall
be deemed material and shall survive expiration or sooner termination of this Lease. 
 16.11 Remedies Cumulative; No
Waiver. No remedy or election hereunder shall be deemed exclusive, but shall wherever possible, be cumulative with all other remedies at law or in equity. No 

 
waiver of any provision hereof shall be deemed a waiver of any other provision hereof or of any subsequent breach of the same or any other provision. No waiver of any breach shall affect or alter
this Lease, but each and every term, covenant and condition of this Lease shall continue in full force and effect with respect to any other then existing or subsequent breach thereof. No reference to any specific right or remedy shall preclude the
exercise of any other right or remedy permitted hereunder or that may be available at law or in equity. No failure by Landlord or Tenant to insist upon the strict performance of any agreement, term, covenant or condition hereof, or to exercise any
right or remedy consequent upon a breach thereof, and no acceptance of full or partial rent by Landlord during the continuance of any such breach, shall constitute a waiver of any such breach, agreement, term, covenant or condition. 

16.12 Tenant’s Financial Statements. Unless Tenant is a publicly traded company, Tenant shall, upon Landlord’s
request, furnish Landlord annually, within one hundred eighty (180) days after the end of each fiscal year of Tenant, copies of the balance sheets of Tenant, as at the close of such fiscal year, and statements of income and retained earnings of
Tenant for such year, prepared in accordance with generally accepted accounting principles or another accounting method reasonably approved by Landlord, and, if such is Tenant’s normal practice, audited by Tenant’s independent certified
public accountants and, if not, certified as true and correct by Tenant’s chief financial officer. Landlord shall keep Tenant’s financial statements provided by Tenant pursuant to this Section 16.12 confidential other than to
Landlord’s officers, directors, employees, agents, accountants, attorneys, mortgagees, or prospective mortgagees, or purchasers or prospective purchasers of Landlord’s interest in the Building, provided that such recipients hold such
information confidential. Tenant also agrees to furnish to Landlord within ten (10) days following Landlord’s written request therefor (which request shall not be made more than once in any fiscal year unless made in connection with a
proposed sale, financing or re-financing of the Building, re-capitalization of Landlord, or following an Event of Default), copies of such financial statements identified above as are then available and
balance sheets and cash flow statements for the then current fiscal year prepared in accordance with generally accepted accounting principles or another accounting method reasonably approved by Landlord, and on an unaudited basis certified as true
and correct by Tenant’s chief financial officer. 
 16.13 Attorney’s Fees. If Landlord or Tenant brings an
action to enforce the terms hereof or declare rights hereunder, the prevailing party in any such action, or appeal thereon, shall be entitled to its reasonable attorneys’ fees and court costs to be paid by the losing party as fixed by the court
in the same or separate suit, and whether or not such action is pursued to decision or judgment. With respect to Landlord’s attorneys’ fees, such fees shall specifically include the fees and expenses of the
in-house legal staff of Landlord and its affiliates. 
 16.14 Landlord Approvals.
Whenever Tenant is required to obtain Landlord’s consent hereunder, Tenant agrees to reimburse Landlord all reasonable out-of-pocket expenses incurred by
Landlord in connection therewith, including reasonable attorney’s fees in order to review documentation or otherwise determine whether to give its consent. Tenant shall pay Landlord’s invoice for any such amounts within thirty
(30) days following Landlord’s delivery of its invoice therefor. Any provision of this Lease which requires Tenant to obtain Landlord’s consent to any proposed action by Tenant shall not be the basis for an award of damages or give
rise to a right of setoff on Tenant’s behalf, but may be the basis for a declaratory judgment or injunction with respect to the matter in question. 

16.15 Landlord’s and Tenant’s Liability. Tenant shall look only to Landlord’s estate in the Property (or
the proceeds thereof) for the satisfaction of Tenant’s remedies with respect to any liability, default or obligation of Landlord under this Lease or otherwise regarding Tenant’s leasing, use and occupancy of the Premises pursuant hereto,
including without limitation for the collection of any monetary obligation, judgment or other judicial process requiring the payment of money by Landlord. None of Landlord’s members, stockholders, officers, directors, partners, trustees,
beneficiaries or employees shall be personally liable hereunder, nor shall any of Landlord’s property, other than the Property, be subject to levy, execution or other enforcement procedure for the satisfaction of Tenant’s said remedies.
Landlord shall not under any circumstances be liable for any special, indirect or consequential damages of Tenant, including lost profits or revenues. No owner of the Property shall be liable under this Lease except for breaches of Landlord’s
obligations occurring while such owner owns the Property. For purposes hereof, “Landlord’s estate in the Property” shall include insurance proceeds, proceeds resulting from a taking and sale proceeds. 

No party other than the Tenant entity itself shall be personally liable for any obligation of Tenant under this Lease, including but not
limited to, any employee, principal, agent, signatory or the like. 

 
Notwithstanding anything in this Lease to the contrary, Tenant shall not under any circumstances be liable for any special, indirect or consequential damages of Landlord, including lost profits
or revenues, except for special, indirect or consequential damages payable by Tenant under Section 2.2 and Section 7.6.2.1, above. 

16.16 Time of Essence. TIME IS OF THE ESSENCE with respect to the due performance of the terms, covenants and conditions
herein contained; provided, however, that no delay or failure to enforce any of the provisions herein contained and no conduct or statement shall waive or affect any of Landlord’s or Tenant’s rights hereunder. 

16.17 Confidentiality. Tenant agrees: (a) to treat the terms of this Lease, and the terms of any existing and future
amendments and modifications to this Lease (the “Confidential Information”) as confidential during the Term of this Lease and for the one (1) year period following the expiration or sooner termination of the Lease
(the “Non-Disclosure Period”), and (b) not to disclose, directly or indirectly, to any third party nor permit any third party to have access to any or all of such
(Confidential Information during the Non-Disclosure Period, including, without limitation, any Property tenants and any brokers (but excluding Tenant’s brokers, agents, attorneys and accountants, provided
that any disclosures to the same are held subject to the provisions of this Section 16.17). Landlord acknowledges that Tenant shall also have the right to disclose such Confidential Information only to the extent that such disclosure is
required by law or court order or by discovery rules in any legal proceeding. Tenant’s agreements with respect to the Confidential Information shall survive the expiration or earlier termination of the Lease. Notwithstanding the foregoing,
Tenant shall have no liability to Landlord for any breach of its obligations under this Section 16.17 (but Landlord shall be entitled to obtain equitable relief to enforce the provisions of this Section 16.17). 

16.18 Submission. Submission of this instrument for examination does not constitute a reservation of or option for lease
of the Premises, and it is not effective as a lease or otherwise until this Lease has been executed by both Landlord and Tenant and a fully executed copy has been delivered to each. 

16.19 Governing Law. This Lease and the rights and obligations of the parties hereunder shall be construed and enforced
in accordance with the laws of The Commonwealth of Massachusetts. 
 16.20 OFAC List. Tenant represents and warrants
that it is not listed, nor is it owned or controlled by, or acting for or on behalf of any person or entity, on the list of Specially Designated Nationals and Blocked Persons maintained by the Office of Foreign Assets Control of the United States
Department of the Treasury, or any other list of persons or entities with whom Landlord is restricted from doing business with (“OFAC List”). Notwithstanding anything to the contrary herein contained, Tenant shall not
permit the Premises or any portion thereof to be used, occupied or operated by or for the benefit of any person or entity that is on the OFAC List. Tenant shall provide documentary and other evidence of Tenant’s identity and ownership as may be
reasonably requested by Landlord at any time to enable Landlord to verify Tenant’s identity or to comply with any legal requirement or applicable laws. Tenant acknowledges and agrees that as a condition to the requirement or effectiveness of
any consent to any Transfer by Landlord pursuant to Section 12.1, Tenant shall cause the Transferee, for the benefit of Landlord, to affirm, on behalf of such Transferee, the representations of, and to otherwise comply with the
obligations set forth in, this Section 16.20, and it shall be reasonable for Landlord to refuse to consent to a Transfer in the absence of such reaffirmation and compliance. Tenant agrees that breach of the representations and warranties
set forth in this Section 16.20 shall at Landlord’s election be a default under this Lease for which there shall be no cure. This Section 16.20 shall survive the termination or earlier expiration of the Lease. 

16.21 Rent Not Based On Income. No rent or other payment in respect of the Premises shall be based in any way upon net
income or profits from the Premises. Tenant may not enter into or permit any sublease or license or other agreement in connection with the Premises which provides for a rental or other payment based on net income or profit. 

16.22 Force Majeure. In the event Landlord or Tenant shall be delayed or hindered in or prevented from the performance of
any act required under this Lease to be performed by Landlord or Tenant, as applicable, by reason of strikes, lockouts, labor troubles, inability to procure materials, failure of power, restricted governmental law or regulations, riots,
insurrection, war or other reason of a like nature (collectively, “Force Majeure”), then performance of such act shall be excused for the period of 

 
the delay, and the period for the performance of any such act shall be extended for a period equivalent to the period of such delay (provided, however, that in no event shall this
Section 16.22 excuse the payment of sums due under this Lease). 
 ARTICLE 17 ROOFTOP RIGHTS 

17.1 Rooftop Rights. 

Landlord grants Tenant the appurtenant, non-exclusive, and irrevocable (except upon the expiration or
earlier termination of this Lease) license at no additional charge, but otherwise subject to the terms and conditions of this Lease, to use a portion of the roof of the Building approved by Landlord (the “Rooftop Installation
Area”) to operate, maintain, repair and replace a supplemental heating, ventilating and air conditioning unit (or units), appurtenant to the uses permitted under Section 7.1 of the Lease (collectively, the
“Supplemental HVAC Unit”). The exact location and layout of the Rooftop Installation Area shall be approved by Landlord and Tenant in their reasonable discretion. Any electricity consumed by the Supplemental HVAC Unit
shall be paid for by Tenant in the manner applicable to electricity to the Premises under this Lease. 
 Tenant shall install the
Supplemental HVAC Unit at its sole cost and expense, at such times and in such manner as Landlord may reasonably designate and in accordance with all of the provisions of this Lease, including without limitation Section 8.3. Tenant shall
not install or operate the Supplemental HVAC Unit until it receives prior written approval of the plans for such work in accordance with Section 8.3. Landlord may withhold approval if the installation or operation of the Supplemental
HVAC Unit reasonably would be expected to damage the structural integrity of the Building. Landlord may condition its approval of the Supplemental HVAC Unit upon Tenant’s structural re-enforcement of the
roof as deemed necessary or desirable by Landlord in order to accommodate the Supplemental HVAC Unit. Tenant shall cooperate with Landlord as reasonably required to accommodate any re-roofing of the Building
during the Term and Tenant shall be responsible for any costs associated with working around, moving or temporarily relocating Tenant’s Roof Equipment. Landlord shall use commercially reasonable efforts to complete any such re-roofing as soon as is practicable. Tenant shall have access to the rooftop for the purposes of exercising its rights and obligations under this Article 17 twenty-four (24) hours per day and seven
(7) days per week, subject to Landlord’s reasonable security measures. 
 Tenant shall engage Landlord’s roofer before
beginning any rooftop installations or repairs of the Supplemental HVAC Unit, whether under this Article 17 or otherwise, and shall always comply with the roof warranty governing the protection of the roof and modifications to the roof.
Tenant shall obtain a letter from Landlord’s roofer following completion of such work stating that the roof warranty remains in effect. Tenant, at its sole cost and expense, shall cause a qualified employee or contractor to inspect the Rooftop
Installation Area at least quarterly and as often as recommended by the manufacturer of the Supplemental HVAC Unit and correct any loose bolts, fittings or other appurtenances and shall repair any damage to the roof caused by the installation or
operation of the Supplemental HVAC Unit. Tenant shall pay Landlord following a written request therefor, with the next payment of Base Rent, (i) all applicable taxes or governmental charges, fees, or impositions imposed on Landlord because of
Tenant’s use of the Rooftop Installation Area and (ii) the amount of any increase in Landlord’s insurance premiums as a result of the installation of the Supplemental HVAC Unit. The Supplemental HVAC Unit shall be screened or
otherwise designed so that it is not visible from the ground level of the Property. Unless Landlord notifies Tenant to the contrary at least thirty (30) days prior to the expiration of the Term, the Supplemental HVAC Unit shall be removed by
Tenant at its own expense at the expiration or earlier termination of the Term or Tenant’s right to possession hereunder and, in such event, Tenant shall repair any damage caused by such removal. 

Tenant agrees that the installation, operation and removal of the Supplemental HVAC Unit shall be at its sole risk. Tenant shall indemnify and
defend Landlord and Landlord’s agents and employees against any liability, claim or cost, including reasonable attorneys’ fees, incurred in connection with the loss of life, personal injury, damage to property or business or any other loss
or injury (except to the extent due to the negligence or willful misconduct of Landlord or its employees, agents or contractors) arising out of the installation, use, operation, or removal of the Supplemental HVAC Unit by Tenant or its employees,
agents, or contractors, including any liability arising out of Tenant’s violation of this Article 17. The provisions of this paragraph shall survive for one (1) year following the expiration or earlier termination of this Lease.

 Landlord may have granted and may hereafter grant roof rights to other parties, and permit
installations on the rooftop by other parties, including other Building tenants in the event that Tenant is no longer the sole tenant of the Building. If the Supplemental HVAC Unit (i) causes physical damage to the structural integrity of the
Building, (ii) materially interferes with any telecommunications, mechanical or other systems located at or servicing the Building or any building, premises or location in the vicinity of the Building, Tenant shall promptly cooperate with
Landlord or any other tenant or third party making such claim to determine the source of such interference and effect a prompt solution at Tenant’s expense (if the Supplemental HVAC Unit caused such interference or damage). 

Based on Landlord’s good faith determination that such relocation is necessary, Landlord reserves the right to cause Tenant to relocate
the Supplemental HVAC Unit located on the roof to comparably functional space on the roof by giving Tenant prior notice of such intention to relocate. If within thirty (30) days after receipt of such notice Tenant has not agreed with Landlord
on the space to which the Supplemental HVAC Unit is to be relocated, the timing of such relocation, and the terms of such relocation, then Landlord shall have the right to make all such determinations in its reasonable judgment. Landlord agrees to
pay the reasonable cost of moving the Supplemental HVAC Unit to such other space, taking such other steps necessary to ensure comparable functionality of the Supplemental HVAC Unit, and finishing such space to a condition comparable to the then
condition of the current location of the Supplemental HVAC Unit. Tenant shall arrange for the relocation of the Supplemental HVAC Unit within sixty (60) days after a comparable space is agreed upon or selected by Landlord, as the case may be.
In the event Tenant fails to arrange for said relocation within the sixty (60) day period, Landlord shall have the right to arrange for the relocation of the Supplemental HVAC Unit at Landlord’s expense, all of which shall be performed in
a manner designed to minimize interference with Tenant’s business. 
 [remainder of page left intentionally blank –
signatures on following page] 

 IN WITNESS WHEREOF, Landlord and Tenant have executed this Lease the day and
year first above written. 
  

					
	LANDLORD:
	
	DIV BEDFORD, LLC
	a Massachusetts limited liability company
		
	By:	 	Bedford Manager Corp., a
		 	Massachusetts corporation
			
		 	By:	 	/s/ Richard McCready
		 	Name:  Richard McCready
		 	Title:  [President or Vice President]
			
		 	By:	 	/s/ Jordanna Ferreira
		 	Name:  Jordanna Ferreira
		 	Title:  [Treasurer or Assistant Treasurer]
	
	TENANT:
	
	KALEIDO BIOSCIENCES, INC., a
	Delaware corporation
		
	By:	 	/s/ Michael Bonney
	Name:  Michael Bonney
	Title:   Chairman and CEO
		
	By:	 	/s/ Jeffrey R. Moore
	Name:  Jeffrey R. Moore
	Title:   SVP Finance & Administration/Treasurer

 EXHIBIT 1.1-1 

PLAN OF PREMISES 
  

 

  
 

 

 EXHIBIT 1.1-2 

LEGAL DESCRIPTION 
 4-18 Crosby Drive, Bedford, Massachusetts 
 Real property at 4-18 Crosby
Drive, in the Town of Bedford, County of Middlesex, Commonwealth of Massachusetts, described as follows: 
 Parcels 1 & 2 

A certain parcel of land situated on the westerly side of Crosby Drive in the Town of Bedford, in the County of Middlesex, Commonwealth of Massachusetts,
bounded and described as follows: 
 Beginning at a point in the westerly line of Crosby Drive at the most northerly corner of the granted premises at land
now or formerly of Beacon Properties Limited Partnership, thence 
  

			
	S 16° 24’ 24” E	  	a distance of Nine Hundred Ninety-Two and Fifty-Four Hundredths feet (992.54’) to a point; thence
		
	S 15° 54’ 05” E	  	a distance of Two Hundred Twenty-Six and Eight Hundredths feet (226.08’) to a point; thence
		
	S 74° 05’ 55” W	  	a distance of Twenty-Two and No Hundredths feet (22.00’) to a point; thence
		
	S 15° 54’ 05” E	  	a distance of Four and Three Hundredths feet (4.03’) to a point; thence
		
	SOUTHERLY	  	and curving to the left along the arc of a curve having a radius of Nine Hundred Seventy and Seventy-Three Hundredths feet (970.73’), a length on One Hundred Fifty-Nine and Sixty-Nine Hundredths feet (159.69’) to a point;
thence
		
	SOUTHERLY	  	and curving to the right along the arc of a curve having a radius of Twenty and No Hundredths feet (20.00’), a length of Thirty-One and Four- Hundredths feet (31.04’) to a point; the
previous six (6) courses being along the westerly line of Crosby Drive; thence
		
	S 63° 35’ 55” W	  	a distance of Sixty-Five and Ninety Hundredths feet (65.90’) to a point; thence
		
	WESTERLY	  	and curving to the right along the arc of a curve having a radius of Thirty and No Hundredths Feet (30.00’), a length of Thirty-Five and Fifty-Five Hundredths feet (35.55’) to a point; thence
		
		  	And curving to the left along the arc of a curve having a radius of Four- Hundred Twenty and no hundredths feet (420.00’), a length of Three Hundred Two and Eighty Hundredths feet (302.80’) to a point; thence
		
	N 89°49’ 15" W	  	a distance of Two Hundred Ninety-Three and Four Hundredths feet (293.04’) to a point; thence
		
	NORTHWESTERLY	  	and curving to the right along the arc of a curve having a radius of One Hundred and No Hundredths feet (100.00’), a length of One Hundred Nineteen and Thirty-Six Hundredths feet (119.36’) to a point at a Parcel 4; the
previous five (5) courses being along the northerly line of Crosby Road; thence
		
	N 21° 25’ 56” W	  	a distance of Five Hundred Four and Seventy Hundredths feet (504.70’) to a point; thence

			
	N 21° 56’ 20” W	  	a distance of Two Hundred Eighty-Three and One Hundredth feet (283.01’) to a point at Parcel 3; the previous two (2) courses by Parcel 4; thence
		
	N 64°00’ 04” E	  	a distance of Sixty-Four and Forty-Three Hundredths feet (63.43’) to a point; thence
		
	N 41°27’ 31” E	  	a distance of One Hundred Seventy and Thirty-Three Hundredths feet (170.33’) to a point at land now or formerly of Beacon Properties Limited Partnership, the previous two (2) courses by Parcel
3; thence
		
	N 57° 00’14” E	  	a distance of Two Hundred Ninety-Two and Thirty-Four Hundredths feet (292.34’) to a drill hole; thence
		
	N 58° 05’ 16” E	  	a distance of Ninety-One and Ten Hundredths feet (91.10’) to a drill hole; thence
		
	N 57° 40’ 22” E	  	a distance of Two Hundred Fifteen and Ninety-Nine Hundredths feet (215.99’) to the Point of Beginning.

 The above described Parcel of land contains an area of 838,376 square feet, more or less or 19.2465 acres, more or less, and
is more particularly shown as Parcel 1 & 2 on a plan entitled “Plan of Land at 2-14 Crosby Drive, Bedford, Mass (Middlesex County) prepared for Bedford Business Park Limited Partnership, Scale: 50
feet to an inch, dated Nov. 1, 1996, by the BSC Group, Inc.,” recorded with the Middlesex South District Registry of Deeds as Plan No. 1246 of 1996. 

Parcel 3 
 A certain parcel of land situated off
the northwesterly end of Crosby Road in the Town of Bedford, in the County of Middlesex, Commonwealth of Massachusetts bounded and described as follows: 

Beginning at a point in the most southerly corner of the granted premises at the most westerly corner of Parcel 1 & 2 at Parcel 4; said point being Seven
Hundred Eighty-seven and Seventy-One Hundredths feet (787.71’) along the line separating Parcel 1 & 2 and Parcel 4 from the most northwesterly end of Crosby Road, thence 

 

			
	N 23° 06’ 22” W	  	by Parcel 4, a distance of Two Hundred Ninety-Nine and Fifty-One Hundredths feet (299.51’) to a point at land now or formerly of Beacon Properties Limited Partnership; thence
		
	N 59° 22’ 33” E	  	a distance of Two Hundred Nine and Ninety-Five Hundredths feet (200.95’) to a point; thence
		
	S 25° 23’ 47” E	  	a distance of Two Hundred Fifty and Seventy-Seven Hundredths feet (250.77’) to a point at Parcel 1 & 2; the previous two (2) courses by land now or formerly of Beacon Properties Limited Partnership; thence
		
	S 41° 27’ 31” W	  	a distance of One Hundred Seventy and Thirty-Three Hundredths feet (170.33’) to a point; thence
		
	S 64° 00’ 04” W	  	a distance of Sixty-Four and Forty-Three Hundredths feet (64.43’) to the Point of Beginning; the previous two (2) courses by Parcel 1 & 2.

 The above described Parcel of land contains an area of 60,990 square feet, more or less, or 1.4001 acres, more or less, and is
more particularly shown as Parcel 3 on a plan entitled “Plan of Land at 2-14 Crosby Drive, Bedford, Mass. (Middlesex County) prepared for Bedford Business Park Limited Partnership, scale 50 feet to an
inch, dated Nov. 1, 1996 by the BSC Group, Inc.” recorded with the Middlesex South District Registry of Deeds as Plan No. 1246 of 1996. 

 Parcel 4 

All of Bedford Business Park Limited Partnership’s Right, Title and Interest in and to the following described Parcel of Land: 

A certain Parcel of land situated on the northwesterly end of Crosby Road in the Town of Bedford, in the County of Middlesex, Commonwealth of Massachusetts,
bounded and described as follows: 
 Beginning at a point in the most westerly end of Crosby Road at the most southerly corner of the granted premises at the
easterly line of Route 3; thence 
  

			
	N 21°25; 56” W	  	by the easterly line of Route 3, a distance of Four Hundred Fifty-Three and Seven Hundredths feet (453.07’) to a stone bound at land now or formerly of Beacon Properties of Limited Partnership; thence
		
	N 21°48’ 17” W	  	a distance of Three Hundred Ninety-One and Ninety-One Hundredths feet (391.91’) to a point; thence
		
	N 23° 01’27”W	  	a distance of One Hundred seventeen and Eighty-two Hundredths feet (117.82’) to a point; thence
		
	N 05° 17’ 44” W	  	a distance of Forty-One and Thirty-Two Hundredths feet (41.32’) to a point; thence
		
	N 22° 50’28” W	  	a distance of One Hundred Seven and Nine Hundredths feet (107.09’) to a point; thence
		
	N 00° 22’ 29” W	  	a distance of Fourteen and Ninety-Six Hundredths feet (14.96’) to a point; thence
		
	N 59° 22’ 23” E	  	a distance to Twenty-Four and Fourteen Hundredths feet (24.14’) to a point at Parcel 3; the previous six courses by land now or formerly of Beacon Properties Limited Partnership; thence
		
	S 23° 06’ 22” E	  	by Parcel 3, a distance of Two Hundred Ninety-Nine and Fifty-One Hundredths feet (299.51’) to a point at Parcel 1 & 2; thence
		
	S 21° 56’ 20” E	  	a distance of Two Hundred Eighty-Three and One Hundredth feet (283.01’) to a point; thence
		
	S 21° 25’ 56” E	  	a distance of Five Hundred Four and Seventy Hundredths feet (504.70’) to a point in the northwesterly end of Crosby Road; the previous two (2) courses by Parcel 1 & 2; thence
		
	S 25°47’ 26” W	  	along the northwesterly end of Crosby Road, a distance of Fifty-Nine and Twenty-Five Hundredths feet (59.25’) to the Point of Beginning.

 The above described Parcel of land contains an area of 46,110 square feet, more or less, or 1.0585 acres, more or less, and is
more particularly shown as Parcel 4 on a plan entitled “Plan of Land at 2-14 Crosby Drive, Bedford, Mass. (Middlesex County) prepared for Bedford Business Park Limited Partnership, scale 50 feet to an
inch, dated Nov. 1, 1996 by the BSC Group, Inc.” recorded with the Middlesex South District Registry of Deeds as Plan No. 1246 of 1996. 
 LESS
AND EXCEPT so much of Parcel 4 as was taken by virtue of Layout No. 7652 and Order of Taking by the Massachusetts Department of Highways, for the alteration of Route 3, dated September 11, 2002, recorded in Book 36449, Page 166, as shown
on Plan No. 998 of 2002, recorded therewith. 

 A portion of Parcel 4 is Registered Land as follows: 

One-half Crosby Road opposite Lot 2, but not opposite Lot 1, as shown on a subdivision plan, as approved by the
Court, filed in the Land Registration Office for the South Registry District of the Middlesex County in Registration Book 855, Page 41, with Certificate No. 144991 (Plan No. 31882B). 

Together with benefit of that certain appurtenant easement as set forth in Easement Agreement by and between MA-Crosby
Corporate Center, L.L.C. as Grantor, and Boston Properties Limited Partnership, as Grantee, dated as of May 7, 2004, recorded in Book 43035, Page 303 and filed as Document No. 1337304. 

Parcel 5 
 A parcel of land in the Town of Bedford,
County of Middlesex, comprising a portion of the January 29, 1952 (Layout No. 3933) State highway layout of Route 3, the December 1, 1953 (Layout No. 4102) State highway alteration of Crosby Road, the September 11, 2002
(Layout No. 7652) State highway alteration of Crosby Drive, and the October 18, 2006 (Layout No. 7977) State highway alteration of Route 3 and bounded by the line described as follows: 

 

			
	Beginning	  	at a point on the northerly location line of Section 3 of the aforesaid September 11, 2002 (Layout No. 7652) State highway alteration of Crosby Drive, said point bearing N 48°20’25”
E and being 107.94 feet distant from station 4+70.51 of Auxiliary baseline “A” of said 1953 layout and extends thence, leaving said location line by a curve to the right of 490.00 feet radius and 217.79 feet with a chord
bearing of S 3°01’34” W and a chord length of 216.00 feet;
		
	thence	  	by a curve to the right 165.00 feet radius 256.52 feet with a chord bearing S 60°17’48” W and a chord length of 231.45 feet;
		
	thence	  	N 75°09’57” W 50.62 feet;
		
	thence	  	N 54°13’39” W 302.73 feet;
		
	thence	  	N 45°43’32” W 268.93 feet;
		
	thence	  	N 44°15’11” W 79.75 feet to a point on the northerly location line of the aforesaid October 18, 2006 (Layout No. 7977) State highway alteration, said point bearing N 53°11 ‘34” E and being 169.21
feet distant from station 157+08.65 of the Main baseline of said 1952 layout;
		
	thence	  	following the location line of said 2006 (Layout No. 7977) State highway alteration in four courses easterly and southeasterly about 14 feet, 14 feet, 13 feet, and 25 feet, respectively;
		
	thence	  	following the location line of said December 1, 1953 (Layout No. 4102) State highway alteration in two courses easterly and southeasterly about 274 feet and 330 feet respectively;
		
	thence	  	following said 2002 State highway layout in two courses northeasterly and southeasterly about 118 feet and 30 feet respectively to the point of beginning.

 Being shown as Parcel 4-L5-1 on a plan
entitled: “Massachusetts Department of Transportation Plan of Road in the Town of Bedford Middlesex County Altered and Laid Out as a State Highway by the Massachusetts Department of Transportation Highway Division Scale: 40 Feet to the
Inch”. Plan prepared by: BSC Group, Inc. 15 Elkins Street, Boston MA 02127, and recorded as Plan No. 512 of 2015. 

 EXHIBIT 1.3 

Plan 
  

 

 EXHIBIT 6.1 

CLEANING SPECIFICATIONS 

TENANT AREAS 
  

			
	Frequency                	  	Service Description
	 Nightly
	  	Dust sweep hard surfaces flooring.
		
	 Nightly
	  	Damp mop hard surfaced flooring to remove spills and stains.
		
	 Nightly
	  	Vacuum carpeted areas and rugs. Spot dean stains.
		
	Nightly	  	Empty wastepaper baskets and waste receptacles, etc. Replace plastic liners in wastebaskets,
		
	Nightly	  	Remove waste paper and waste materials to designated area in the building using janitor carriages.
		
	Nightly	  	Dust and wipe clean windowsills, filing cabinets, table, bookcases, shelves and ledges. Rotating areas of the building to complete dusting all areas weekly.
		
	Nightly	  	Spot clean to remove dirt, finger marks, smudges, etc. from doors, switch plates, light switches, wall and glass areas adjacent to doors, push plates, handles, railing, etc.
		
	Nightly	  	Clean and sanitize drinking fountains and water coolers.
		
	Weekly	  	Dust baseboards, chair rails, trim, molding and other “low-dust” areas. Rotating areas of the building to complete weekly.
		
	 Once every

Three Months
	  	Perform high dusting which includes the following:
		
		  	Dust pictures, frames, charts, graphs and similar wall hangings not reached in nightly cleaning.
		
		  	Dust partitions, ventilating louvers and vents, walls, trim, etc. not reached in nightly cleaning.
		
		  	Dust tops of cabinets, files, etc. not reached in nightly cleaning.

			
	 CLEANING SPECIFICATIONS

	  
 ELEVATOR LOBBIES AND PUBLIC
CORRIDORS
  

	Frequency                	  	Service Description
	 Nightly
	  	Dust sweep hard surfaced flooring.
		
	 Nightly
	  	Wash tile flooring.
		
	 Nightly
	  	Vacuum carpeting.
		
	 Nightly
	  	Dust baseboards, trim, louvers, pictures, charts, graphs, doors etc. within reach.
		
	 Nightly
	  	Remove dirt, finger marks, smudges, etc., from doors, door frames, walls switch plates, light switches, glass, push plates, handles, railings, molding, trim, pictures, etc.
		
	 Weekly
	  	Do high dusting within normal reach.
	
	  
 MAIN ENTRANCE LOBBY

 

	Frequency	  	Service Description
	 Nightly
	  	Dust sweep and wash hard surfaces flooring.
		
	 Nightly
	  	Floor mats are to be vacuumed.
		
	 Nightly
	  	Vacuum carpeting.
		
	 Nightly
	  	Dust baseboards, trim, louvers, molding, pictures, charts, planters, furnishings, guard stations and all other fixtures.
		
	 Nightly
	  	Clean and rub down building directory, mail depository and all other decorative metal.
		
	 Nightly
	  	Clean all entrance door glass.
		
	 Nightly
	  	Empty and clean all waste receptacles and remove waste material to designated areas in the building.

			
	 CLEANING SPECIFICATIONS

 
 ELEVATORS

 

	Frequency                    	  	Service Descriptions
	 Nightly
	  	Floor In elevator cabs will be properly maintained. If carpeted, vacuum and spot clean; if hard-surfaced, sweep and wash.
		
	 Nightly
	  	Clean and polish doors, inside and outside.
		
	Nightly	  	Clean elevator saddles, door tracks, etc., keeping them free from dirt and debris: polish regularly as needed.
		
	 Nightly
	  	 Hand clean and polish baseboards, trim, railings, etc.

		
	 Nightly
	  	Keep walls, panels, etc. dean and free from fingermarks and smudges: polish as needed using appropriate wood or metal polish.
	
	  
 STAIRWAYS

 

	Frequency	  	Service Descriptions
	 Nightly
	  	Police stairwells and remove trash and debris.
		
	 Weekly
	  	Sweep stairs and landing: dust handrails, stringers, newels and risers, etc.
		
	Quarterly	  	Wash stairs and landings.

			
	 CLEANING SPECIFICATIONS
  

	 LAVATORIES

 

	Frequency                    	  	Service Descriptions
	Nightly	  	Sweep and wash flooring with approved germicidal detergent solution.
		
	Nightly	  	Wash and polish mirrors, shelves, bright work, etc. Including flush meters, piping and toilet seat hinges.
		
	Nightly	  	Wash both sides of toilet seats, wash basins, bowls, and urinals with approved germicidal detergent solution.
		
	Nightly	  	Dust and wipe dears partitions, tile walls, dispensers, doors, receptacles, etc. with special attention to areas behind sinks and around urinals, etc., remove graffiti.
		
	Nightly	  	Fill toilet tissue, soap, and towel and sanitary napkin dispensers to full capacity with supplies.
		
	Nightly	  	Empty and clean towel and sanitary disposal receptacles and remove waste material and refuse to a designated area In the building using Janitor carriages.
		
	Monthly	  	Wash partitions, tile walls and enamel painted surfaces with approved germicidal detergent solution.

 CLEANING SPECIFICATIONS 

Frequency Service Description 
 Keep
locker rooms, service closets, Janitor closets, etc. in neat and clean condition at all times. 
 Employees are to sign in and out for each
shift works. 
 At the conclusion of all work assignments, lights are to be turned off, doors and windows closed and locked and premises
left in neat and orderly condition. 
 Carpet Cleaning Program 
  

	Annually	 Rotary shampoo and extract all common area carpeting including cafeteria eating area, locker rooms, common
entrances, common lobbies, common hallways, elevators, etc. 

 EXHIBIT 7.4 

RULES AND REGULATIONS 
 Note: Rules
below marked with an asterisk (*) do not apply so long as the Premises includes 100% of the rentable area of the Building. 
  

	 	1.	 ALL TENANTS are to conduct their businesses in a manner that shall not unreasonably annoy, disrupt or otherwise
interfere with the rights of other tenants in the office park. 

  

	 	2.	 At no time and under no circumstances shall Landlord have any responsibility for the storage or removal of any
“medical waste”, “infectious waste”, “hazardous medical waste”, “hazardous physical waste” as such terms may from time to time be defined in any municipal, state, or federal statutes, laws, ordinances, rules,
or regulations or may apply to Tenant or to the premises demised to Tenant because of the business, profession or activity carried on in the demised premises by Tenant, Tenant’s servants, agents, employees, invites, or anyone claiming by,
through or under Tenant. 

  

	 	3.	 The common areas and egress pathways must not be obstructed or used for any purpose other than ingress to and
egress from any leased premises. 

  

	 	4.	 Emergency egress stairway doors may NOT be “propped-open” for any reason. These stairways are for
egress only and the stairway doors may be locked from the stair-side to prevent unwanted intrusion into the building. 

  

	 	5.	 Tenant shall operate hvac equipment in a manner that is consistent with standards prescribed by building
management. Tenant shall be responsible for any damage which may occur from improper operation such as leaving a thermostat at its lowest setpoint for an extended period of time causing a coil to freeze. Please check with building management to
confirm proper operating procedures. There are to be NO supplemental heaters or heating elements within tenant spaces. Use of such devices presents a fire hazard. 

 

	 	6.	 High intensity or accent lighting (holiday lighting, candles, heat lamps, etc.) is NOT PERMITTED, except
for such lighting that is customary in connection with laboratory use, as it presents fire hazards. 

  

	 	7.	 As required by local ordinances, Landlord shall, from time to time, test the building’s fire control and
alarm systems. Tenant shall cooperate in familiarizing its employees with such fire alarm systems and shall make each of its employees aware of the fire exits within the Premises and shall cooperate with any fire drills, systems, test, inspections
and/or repairs as may be required from time to time. 

  

	 	8.	 *Building access, Loading Area access and transportation of materials, equipment, furniture, or supplies into
and/or through the building must be scheduled, through the Management Office or Tenant Services Coordinator, to take place during non-business hours. (See “LOADING AREA RULES & REGULATIONS”, below) 

 

	 	9.	 *Any equipment, computers, furniture, or items being removed from the building must be accompanied by a
Property Removal Request (i.e., on Tenant’s letterhead, with authorization evidenced by Tenant’s Office Manager’s signature) 

  

	 	10.	 Each tenant must provide the Property Management Office with a key to access its suite(s). Each key will be
kept, by the Property Manager, in a secure, locked, key box. Each time a suite is re-keyed, a new key must be provided to the Property Management Office. Whenever possible please notify Management Office prior to re-keying so building key systems
can be maintained. 

 No additional locks or bolts of any kind shall be placed upon any of the doors or windows by
Tenant, nor shall any changes be made in existing locks or the mechanism thereof without the prior written consent of the Landlord, which shall not be unreasonably withheld. Tenant must, upon the termination of its tenancy, restore to Landlord all
keys of stores, shops, booths, stands, offices and toilet rooms, either furnished to or otherwise procured by Tenant; and in the event of the loss of any keys so furnished, Tenant shall pay to Landlord the cost thereof. 

 

	 	11.	 There are no animals/pets of any kind (leashed, caged, muzzled) allowed into the building, with exception for
service animals. 

  

	 	12.	 To avoid damage to the building’s plumbing system or to prevent plumbing blockages, restroom trash
receptacles (and NOT the toilets) are to be used for disposing of all paper towels, sanitary napkins, and objects foreign to toilet/plumbing systems. Damage resulting to any such fixtures or appliances from misuse by Tenant or its agents, employees,
or invitees, shall be paid for by Tenant, and Landlord shall not in any case be responsible therefore. 

  

	 	13.	 Parking in Fire Lanes, except for medical and emergency vehicles is PROHIBITED BY LAW. All other vehicles are
subject to being towed at the owner’s expense. 

  

	 	14.	 All plans for proposed improvements to a tenant’s demised premises and any contractor proposed by a tenant
must be approved in advance by Davis Management Co. (See Construction Rules.) 

  

	 	15.	 No tenant may display any type of advertisements that would alienate site visitors or customers from another
tenant’s business. 

  

	 	16.	 Construction Rules and Regulations must be adhered to through the construction/improvement process (plan
approval, permitting, insurance, delivery & construction scheduling, building access, alarm shut downs, inspections, and occupancy permit). See separate Construction Rules & Regulations. 

 

	 	17.	 No trash or debris can be stored within tenant areas that might result in rodent infestation. All food, fluid,
or wet trash must be disposed of in the site trash dumpster at the close of business each day. 

  

	 	18.	 No tenant shall mark, paint, drill into, or in any way deface any part of the Demised Premises or the building
of which they form a part. No boring, cutting, or stringing of wires shall be permitted, except with the prior written consent of the Landlord, and as the Landlord may direct. 

 

	 	19.	 No space in the building, except as provided in individual leases, shall be used for manufacturing, for the
storage of merchandise, or for the sale of merchandise, goods, or property of any kind at auction. 

  

	 	20.	 Delivery carts, hand trucks and similar devices must be properly equipped with rubber tires and protective
guards. Tenant shall be held strictly responsible for any damage to the Premises caused by Tenant’s vendors, suppliers, agents or delivery services. 

  

	 	21.	 No tenant shall occupy or permit any portion of the Demised Premises to be occupied for the possession,
storage, manufacture or sale of narcotics or drugs, or any other illegal substance of any kind. No tenant shall occupy or permit any portion of the Demised Premises to be occupied for the possession, storage, manufacture or sale of liquor of any
kind other than possession of liquor in connection with special events taking place at the Premises if such tenant is carrying 

	 	
host liquor liability insurance satisfactory to Landlord and other than the possession, storage, and use of alcohol as a necessary part of Tenant’s laboratory and pilot production activities
in connection with the permitted use of the Premises. 

  

	 	22.	 Landlord shall have the right to prohibit any advertising by any tenant which, in Landlord’s opinion,
tends to impair the reputation of the building or its desirability as a building for offices or the reputation of the office park or its desirability to office tenants, and upon written notice from Landlord, such tenant shall refrain from or
discontinue such advertising. Tenant shall not use the name of the building or its owner in any advertising without the express prior written consent of the Landlord. 

 

	 	23.	 No tenant shall install or permit the installation or use of any machines dispensing goods for sale, including
without limitation foods, beverages, cigarettes or cigars without first notifying Landlord. 

  

	 	24.	 Canvassing, soliciting and pedaling in the building and the office park are prohibited and each Tenant shall
cooperate to prevent the same by notifying the Landlord. Landlord reserves the right to inspect any parcel or package being removed from the building by Tenant, its employees, representatives and business invitees. 

 

	 	25.	 *The main entrance, lobbies, passages, corridors, elevators and stairways or any exterior portions of the Site
shall not be encumbered or obstructed by Tenant, Tenant’s agents, servants, employees, licensees or visitors. The moving in and out of all safes, freight, furniture, or bulky matter of any description must take place during the hours which
Landlord may determine from time to time. Landlord reserves the right to inspect all freight and bulky matter to be brought into the Building and to exclude from the Building all freight and bulky matter which violates any of these Rules and
Regulations or the Lease of which these Rules and Regulations are part. 

  

	 	26.	 Except as otherwise expressly set forth in the Lease, no curtains, blinds, shades, screens, or signs other than
those furnished by Landlord shall be attached to, hung in, or used in connection with any exterior window or suite entry door of the Premises without the prior written consent of the Landlord. 

 

	 	27.	 *Movement in or out of the Building of furniture or office equipment, or dispatch or receipt by Tenant of any
merchandise or materials which require the use of elevators, stairways, lobby areas, or loading dock areas, shall be restricted to reasonable hours designed by Landlord. Such activity may be supervised by Landlord and performed in the reasonable
manner stated by Landlord. 

  

	 	28.	 Landlord may prohibit any article, equipment, or any other item from being brought into the Building that would
violate this Lease. Tenant is to assume all risk for damage to articles moved and injury to any persons resulting from such activity. If any equipment, property, and/or personnel of Landlord or of any other tenant is damaged or injured as a result
of or in connection with such activity, Tenant shall be solely liable for any and all damage or loss resulting therefrom. 

  

	 	29.	 Landlord shall have the power to prescribe the weight and position of safes and other heavy equipment or items,
which in all cases shall not in the opinion of Landlord exceed acceptable floor loading and weight distribution requirements. All damage done to the Building by the installation, maintenance, operation, existence or removal of any property of Tenant
shall be repaired at the expense of Tenant. 

  

	 	30.	 *Common area corridor doors, when not in use, shall be kept closed. 

	 	31.	 No flammable, explosive, or dangerous fluid or substance shall be used or kept by Tenant in the Premises or
Building, except for those substances as are typically found in similar premises used for general business office purposes or laboratory purposes and are being used by Tenant in accordance with all applicable laws, rules, and regulations and the
Lease. Except as permitted by the within Lease, Tenant shall not, without Landlord’s prior consent, use, store, install, spill, remove, release or dispose of within or about the Premises or any other portion of the Property, any
asbestos-containing materials or any solid, liquid or gaseous material now or hereafter considered toxic or hazardous materials under the provisions of any applicable environmental law which may now or hereafter be in effect. If the foregoing is
permitted by the within Lease or if Landlord does give written consent to Tenant pursuant to the foregoing sentence, Tenant shall comply with all applicable laws, rules and regulations pertaining to and governing such use by Tenant, and shall remain
liable for all costs of cleanup or removal in connection therewith. Tenant shall supply building management with current Material Safety Data Sheets along with maximum quantities of materials stored on site as and when required by the Lease.

  

	 	32.	 Tenant shall not use or occupy the Premises in any manner or for any purpose which would injure the reputation
or impair the present or future value of the Premises, the Building or the office park; without limiting the foregoing, Tenant shall not use or permit the Premises or any portion thereof to be used for lodging, sleeping or for any illegal purpose.

  

	 	33.	 Tenant shall not take any action which would violate Landlord’s labor contracts affecting the Building or
the office park or which would cause any work stoppage, picketing, labor disruption or dispute, or any interference with the business of Landlord or any other tenant or occupant of the Building or with the rights and privileges of any person
lawfully in the Building. Tenant shall take any actions necessary to resolve any such work stoppage, picketing; labor disruption, dispute or interference and shall have pickets removed and, at the request of Landlord, immediately terminate at any
time any construction work being performed in the Premises giving rise to such labor problems, until such time as Landlord shall have given its written consent for such work to resume. 

 

	 	34.	 Tenant shall not install, operate or maintain in the Premises or any other area of the Building, any electrical
equipment which does not bear the U/L (Underwriters Laboratories) seal of approval where typical (unless Tenant shall supply the Landlord with documentation evidencing the safety and capacity of such non U/L approved equipment), or which would
overload the electrical system or any part thereof beyond its capacity for proper, efficient and safe operation as reasonably determined by Landlord, taking into consideration the overall electrical system and the present and future requirements
therefore in the Building. Tenant shall not furnish any cooling or heating to the Premises, including, without limitation, the use of any electronic or gas heating devices, without Landlord’s prior written consent which shall not be
unreasonably withheld. 

  

	 	35.	 All vendors to be contracted by the Tenant must comply with insurance requirements if deemed appropriate by
building management. (See insurance requirements, below.) If Tenant ceases to lease 100% of the Premises initially leased under the Lease, Construction vendors must comply with Construction Rules, see attached. Contractor and contractor’s
sub-contractors must check in with building management, 978-815-4722 or 617-875-5441 upon each daily arrival to the building. 

 

	 	36.	 For daily maintenance service calls, or general tenant requests, questions, or concerns please contact the
Tenant Services Coordinator, Kate Somers, at: (781) 272-4212. Alternatively, tenants may use the web based service request system. Please contact building management for specific instructions and to receive a tenant specific password.

  

	 	37.	 Tenants shall adhere to and familiarize their employees with building safety and evacuation plans as furnished
and modified by the Property Manager. In the event of any building/site-related Emergency, please contact the Tenant Services Coordinator (781)-272-4212. or the Emergency line at (617)-451-1300 x265. 

	 	38.	 The Contractor shall purchase from and maintain in a company lawfully authorized to do business in the
Commonwealth of Massachusetts insurance for protection from claims under workers’ or workmen’s compensation acts and other employee benefit acts which are applicable, claims for damages because of bodily injury, including death, and from
claims for damages, other than to the work itself, to property which may arise out of or result from the Contractors operations, whether such operations be by the Contractor or by a Subcontractor or anyone directly or indirectly employed by any of
them. This insurance shall be of the types and within minimum limits or liability as follows: Worker’s Compensation $500,000, Comprehensive General Liability $1,000,000 per occurrence, $2,000,000 aggregate. Automobile liability insurance on any
vehicle used by Contractor in the performance of the services specified herein with combined single limit coverage of not less than $1,000,000. Please contact Tenant Services Coordinator 617-451-2660 for landlord additional insured entities which
must be named on each certificate of insurance. Certificates of such insurance shall be filed with the Management Company prior to the commencement of the Work. 

Tenant shall maintain insurance coverage as required in the lease. Please contact Tenant Services Coordinator (781)-272-4212 for landlord
additional insured entities which must be named on each certificate of insurance. 
  

	 	39.	 *Access to certain Electric Room and Janitors’ Closets may be restricted. During normal business hours,
access to these areas may be arranged by contacting the Tenant Service Coordinator (see “Work Orders & Service Requests”, below). After hours access to these areas is available by prior arrangement. Please note: these rooms are
not to be used for storage of any items, and any items found stored in these rooms will be disposed of at a cost to the responsible tenant. 

  

	 	40.	 Cleaning of the Premises is performed strictly in accordance with requirements outlined in each respective
lease. 

  

	 	41.	 Tenants shall not store or keep flammable fluids or solvents in their leased premises unless permitted by their
lease. Please see item #30. 

  

	 	42.	 4-18 Crosby Drive parking is only for those tenants who have parking privileges in their lease. Additional
surface parking spaces may be available from time to time on a TAW basis. Please check with the management office for availability. Tenants and their visitors shall obey all parking regulations. 

 

	 	43.	 Bicycles and other vehicles are not permitted inside or to be parked on the walkways outside the Building.
Bicycle parking is available at the bicycle racks. 

  

	 	44.	 *Tenant shall carry out Tenant’s permitted maintenance repairs, alterations and improvements in the
Premises only during reasonable times agreed to in advance by Landlord and in a manner which will not interfere with the rights of other tenants in the Building. 

 

	 	45.	 Tenant shall inform its employees and visitors of the laws and ordinances of the Town/City of Bedford relating
to prohibition of smoking. No smoking will be allowed anywhere inside the building. 

  

	 	46.	 NO natural holiday decorations (trees, wreaths, evergreens decorations, etc.) are allowed within the
building. All such items are categorized by the Bedford Fire Department as fire hazards. 

	 	47.	 Normal Business Hours are Monday through Friday between the hours of 7:00 a.m. and 7:00 p.m., holidays
excluded. 

  

	 	48.	 *Outside normal business hours the building will be locked. In order to gain access to the building, tenants
will be required to use their building access cards. 

  

	 	49.	 Access Cards for the fitness center may be requested from Kate Somers, Tenant Service Coordinator, in writing,
on company letterhead, by fax or electronically, as follows: 

 

	 	•	 	By FAX: 

	 	•	 	By E-Mail:

 617-451-3604 

ksomers@thedaviscompanies.com 

 

  
 Each request for an Access
Card must be submitted by authorized tenant-representatives and must provide, at a minimum, the following information: 
  

	 	•	 	 The full name(s) of the individual(s) for whom access is being requested; 

	 	•	 	 The specific building/door(s) for which access is being requested; 

	 	•	 	 The make(s), model(s) and license plate(s) state and number for any vehicle(s) each applicant may park at the
building; 

	 	•	 	 The full name and signature of the authorized individual requesting the Access Card(s). 

 

	 	50.	 *The building has a loading area which is available for tenant use. 

 

	 	a.	 Operational Hours 7:00a.m. through 5:00p.m. Monday through Friday and 7:00a.m. for deliveries and removals. Use
of the loading dock outside these hours can be arranged at tenant cost for building personnel to open and secure the loading dock as necessary. 

  

	 	b.	 Requests for Loading must be pre-scheduled, 48 hours in advance, through the Property Management Office. Use of
the Loading Area for staging deliveries, which might conflict with other scheduled deliveries, will not be permitted. 

  

	 	c.	 Any shipping, packing, staging, rigging, building protection materials generated as part of a delivery must be
cleaned-up and removed by the delivery company or by the tenant responsible for receiving the delivery, otherwise such tenant will be charged with the associated disposal costs. 

 

	 	51.	 Handicapped Parking Spaces are for those who need them and have the appropriate license plates or vehicle
identification. Any abuse of handicapped parking spaces may be reported directly to The Property Management Office. 

  

	 	52.	 Visitor parking is allowed only for visitors of specific tenants. 

 CONSTRUCTION RULES 

(Revised 5/20/14) 

Section I 
 BUILDING
STANDARDS 
 These guidelines provide the standards to be followed for any construction in the building. Also listed are the responsibilities of both
the Contractor and the Tenant for construction of leased premises. Questions and comments are invited. Please address them to Landlord: 

c/o The Davis Companies 

Attn: Jason Biedrzycki 

Senior Property Manager 

125 High Street 21st Floor 

Boston, MA 02110 
 Or
Contact 
 (617) 451-1300 

Assistant Property Mgr. Ron Dorazio 

617-875-5441 
 GENERAL 

Contractor understands the building and the office park are occupied by tenants and will use best efforts to not interrupt the work of others or create an
unpleasant situation for current occupants. Disruption of tenant’s production process will result in substantial claims against the contractor. Contractor shall not store supplies or equipment in public area or common areas and shall leave all
public/common areas clean each night. Primary construction access shall be through the east entry. 
 In addition, contractor will clean common areas and
driveway/pavement areas of any material that is tracked onto common areas and pavement from its operation and use best efforts to keep dust down. Contractor will coordinate its work within tenant spaces to minimize disruption and will seek property
manager’s approval of methods for this work. 
 Contractor acknowledges and understands that he will be working around existing tenants and new tenant
equipment, inventory and personnel and will take every precaution to prevent injury and/or claim. 
 Contractors must provide all of their own equipment,
tools, phones, etc. Building equipment is not available to the contractors. 
 Contractor and Contractor’s sub-Contractors must check in with
building management, Ron: 617-875-5441 or Doug: 617-592-0719 upon each daily arrival to the building. 
 PLANS 

All plans are subject to prior approval by building management. Contractor shall provide building management with copies of all construction plans as approved
by the Town of Bedford along with copies of all as-built drawings. 

 BUSINESS HOURS 

General Business Hours for the building are Monday through Friday 8AM to 5PM. 

DISTURBANCE 
 Work shall be scheduled so as not to disturb
surrounding tenants in any way. Knowingly offensive work such as coring, oil painting, polymix, sawing, or any operation which can cause noise or odor disturbances to other tenants shall be conducted during non-business hours. 

Demolition shall be conducted during non-business hours only. Demolition debris is to be placed in hampers and covered during transport from the work area to
the disposal area and removed from the premises during non-business hours only. 
 *Common area work shall be conducted during non-business hours. 

Contractor shall at all times minimize noise or activities which may be disturbing to residential neighbors, i.e. trucking activities, light testing,
alarm testing, etc. 
 Radios are not allowed. 
 Smoking is
not permitted anywhere inside the building. 
 ELEVATORS 

Contractor shall not exceed elevator loading limits and will be held responsible for any repairs necessitated due to overloading. 

At all times, building elevator pads must be used by construction personnel to protect the elevators. Building Management shall be notified 24 hours in
advance of intended use of elevators for construction purposes. Extended use of the elevator for construction purposes shall not be allowed during business hours. 

*TRASH AND DEBRIS 
 Removal of trash and debris shall be
conducted during non-business hours. Placement of dumpsters is to be arranged with building management. The building dumpsters are not available for construction use or for the disposal of Hazardous Substances. 

*DELIVERIES 
 Delivery of any bulk stock or materials is
to be scheduled with building management 24 hours in advance. In most cases, bulk stock deliveries will be permitted only during non-business hours. Delivery vehicles which do not fit into the loading zone, i.e. tractor trailers, large flat beds,
etc., are not permitted in the parking lot during business hours. 
 FIRE ALARM AND SPRINKLER 

The building is sprinkler-ready in compliance with the Massachusetts State Building code. Alterations to the existing sprinkler system or changing of head
placement requires Landlord approval. All work must comply with the State Building Code as required. 
 The building(s) are equipped with multi-zone
smoke detection and fire alarm systems. Capacity will be provided to our audible fire alarm system and connection points per floor for code 

 
required devices. The electrical contractor must coordinate final tie-in with the building alarm company and the Management Office. A 48-hour advance notice is required. The Tenant is
responsible for any costs incurred, such as Fire Alarm/Sprinkler system impairments and any required site staff overtime. 
 A copy of the
Contractor’s Certificate of Insurance and Sprinkler Permit must be in the Management Office prior to the start of any construction. 
 PARKING

 All construction related vehicles shall be parked as directed by building management. Vehicles in violation are subject to tow at the vehicle
owner’s expense. 
 INSURANCE 
 The Contractor
shall purchase from and maintain in a company lawfully authorized to do business in the Commonwealth of Massachusetts insurance for protection from claims under workers’ or workmen’s compensation acts and other employee benefit acts which
are applicable, claims for damages because of bodily injury, including death, and from claims for damages, other than to the work itself, to property which may arise out of or result from the Contractors operations, whether such operations be by the
Contractor or by a Subcontractor or anyone directly or indirectly employed by any of them. 
 Contractor agrees to carry, at Contractor’s sole expense,
the following insurance coverage: 
  

	A.	 Workers Compensation Insurance in the statutory amount and employer’s liability coverage in an amount of
at least Five Hundred Thousand Dollars ($500,000). 

  

	B.	 Automobile liability insurance on any vehicle used by Contractor in the performance of the services specified
herein with combined single limit coverage of not less than One Million Dollars ($1,000,000). 

  

	C.	 Comprehensive general liability insurance with combined single limit coverage of not less than One Million
Dollars ($1,000,000) per occurrence, $2,000,000 aggregate. Said coverage shall include provisions for blanket contractual liability, personal injury and broad form property damage. 

 

	D.	 All-Risk property insurance coverage for tools and equipment brought onto and/or used at the Property, the
amount of which is equal to the replacement costs of all such tools and equipment. 

 The insurance described above shall
be in the name of Contractor; provided, however, general liability policy shall name as additional insureds the following parties: 
 4-18 Crosby Drive,
Bedford MA: 
 Additional Insureds: 

Santander Bank, N.A. 

DIV Bedford, LLC 

Davis Management Company, LLC 

 Certificate Holder: 

DIV Bedford, LLC 

c/o The Davis Companies 

125 High Street 21st floor 

Boston, MA 02110 
 Certificates
of such insurance shall be filed with the Management Company prior to the commencement of the Work. 
 CLEANING 

The construction contractor is responsible for doing his/her part to keep common areas clean at all times. Any extra cleaning that may be necessary due to
construction contractor’s negligence will be performed by building cleaners at construction contractor’s expense. 
 SCHEDULING 

Building management shall be kept informed of job schedule and changes. 

HVAC 
 Construction contractor shall be responsible for
the replacement of filters and the proper cleaning of all coils, drains, and pans on all HVAC equipment affected by construction. Ultra Services Inc 978-667-8800, the building HVAC contractor, shall be consulted on all planned HVAC modifications.

 SUBCONTRACTORS 
 General Contractor represents that
all subcontractors will perform in accordance with these building rules. The general contractor must provide building management with a contact list of all subcontractors with contact name, phone number, and pager number. 

Section II 
 RULES FOR
TENANT CONTRACTORS 
 The following additional rules have been established as an effective mechanism to enable contractors and Tenants to work freely
with minimum conflict. 
 This is private property and access is by permission only. Permission to enter will be granted to each Tenant Contractor and its
employees who are entering for the purpose of performing work in the building. Access for any other reason will not be permitted. 
  

	1.	 Each General Contractor or Contractor is required to submit a contact list including emergency contact numbers
(pager/cell phone) of all sub contractors who will be working on site. 

  

	2.	 FIRE IMPAIRMENT & HOT WORKS REQUIREMENTS: 

All FIRE ALARM IMPAIRMENTS and/or ALARM DEACTIVATIONS must be coordinated through the Property Manager. The General Contractor is required to
obtain a smoke detector bagging permit from the local Fire Department, or have the fire alarm plugged out on a daily basis. The costs for the alarm plug outs or bagging permit are the contractor’s responsibility. Any costs resulting from
false alarms (Fire Department) will be the responsibility of the Tenant and the Tenant’s Contractor. The Tenant shall be responsible for managing the Contractor(s) who are performing its construction/renovations. 

 HOT WORKS requests and BURN PERMIT letter(s) need to be obtained and approved through the
Property Management Office. All Fire Watches required by the Bedford Fire Department will be at the Tenant/Contractor’s cost. 
  

	3.	 Electrical power will originate from the tenant meter/panel located in the electrical rooms. Any temporary 120
volt service must originate from one of these locations and be removed as soon as the Tenant panel is installed. A prorated cost will be back charged to the Tenant for temporary electrical power provided for their construction use, which is
supplied by base building meters/panels. 

  

	4.	 Contractors can only utilize the area designated by their contract for storage of materials and work. No
materials are to be left in the common areas of the building including but not limited to hallways, elevator landings, stairways, janitor/storage closets, electrical closets, or any parking spaces (interior or exterior). Any material found in
these locations without prior approval will become the sole property of the Management Company. 

  

	5.	 Water for construction and cleaning tools is available in the janitor closets. These closets are kept locked.
These closets are not to be used for the disposal of paint or plaster. 

  

	6.	 Any fire alarm disconnects must be coordinated with the Management Office. 

 

	7.	 All contractor personnel and materials must enter the building through the Rear Entry and loading dock only.
There is no transportation of materials, or tools, in the passenger elevators without protecting ALL SURFACES. Scheduling the use of an elevator during specified times: Non-business or Light Traffic Periods. Materials must be of a length or cut to a
length that will not strike ceilings or wall surfaces, and any damage caused to any elevator surface will result in repair or replacement cost being the responsibility of that vendor and tenant. Contractors are not to use any alarmed side doors for
egress exits. Rubber wheels will be required on all carts and dollies used. 

  

	8.	 It is the Contractor’s responsibility to discard all debris and trash into a container which the
contractor or tenant supplies. There will be no disposal into building trash compactors or containers. Any additional cleaning of common areas which is generated by the contractor during construction/renovations will be billed back to the Tenant.

  

	9.	 All phone and electrical wiring must be in conduit. 

 

	10.	 It is the responsibility of the Tenant and contractor to minimize the amount of debris/odor which emits from
the space. 

  

	11.	 Fire stopping will be provided by general contractor for electrical, plumbing, etc. 

 

	12.	 Appropriate temporary protection and donage must be in place prior to any placement of crane out riggers. All
delivery trucks or cranes must be of approved weight. 

 Section III 

TENANT FINISH PROCEDURE 
 CONSTRUCTION

 The following is the suggested procedure as you prepare to complete the construction of a leased space: 

 

	 	1.	 Tours are available for architects/contractors to familiarize themselves with existing conditions. These are
conducted with the Property Manager through an appointment with him, (617) 451-1300 or (617) 875-5441 

 

	 	2.	 Submit plans and specifications to the Management Office for verification. The plans and specification are to
be in the following form: 

  

	 	A.	 Architectural Drawings 

 

	 	1.	 Floor plan indicating any proposed demolition 

 

	 	2.	 Floor plans indicating partition construction and location 

 

	 	3.	 Reflected ceiling plans indicating any suspended ceiling or other equipment 

 

	 	4.	 Interior elevation and exterior walls 

 

	 	5.	 All built-in equipment, casework, counters, shelving, etc.

  

	 	6.	 All stairs and corridors adjacent to showrooms must be clearly delineated 

 

	 	7.	 All architectural drawings shall be stamped by a Massachusetts Registered Architect. 

 

	 	B.	 Electrical Drawings 

 

	 	1.	 Complete electrical drawings, floor plans and specifications 

 

	 	2.	 Complete schedules of panel board circulating and final load breakdown 

 

	 	3.	 Provisions for special electrical equipment (i.e., copiers, computers, telephone systems, etc.)

  

	 	4.	 Properly stamped drawings by a Massachusetts Licensed Electrical Engineer 

 

	 	C.	 HVAC Drawings 

 

	 	1.	 Completed HVAC drawings and specifications 

 

	 	2.	 Proposed connection to building services 

 

	 	3.	 Cooling and heating load calculations, including equipment requiring special HVAC provisions (i.e., computer)

  

	 	4.	 Property stamped drawings by a Massachusetts Licensed Mechanical Engineer 

 

	 	D.	 Fire Protection Drawings 

 

	 	1.	 Drawings and specifications must show alarm speakers, pull stations, and sprinkler systems

  

	 	2.	 Drawings must clearly delineate all changes the Tenant wishes to make to location, extent and number of heads
and run outs 

  

	 	3.	 Insurance test certificates must be provided for any sprinkler work 

 

	 	4.	 Drawings shall include all requirements of local authorities including engineered hydraulic calculations as
necessary. 

 It is suggested that the General Contractor set up an informal meeting with the local Inspectional Services
Department for the property involved. 
 The Landlord will not serve as an interpreter of the Codes. The Tenant plans must comply with Code as
interpreted/implemented by the State and local (city/town) requirements. All wood must comply with the fire retardant treatment prescribed in the Code. 

The following must be furnished to the Property Manager prior to commencement of construction by your contractor: 

 

	 	1.	 Copy of Building Permit issued 

 

	 	2.	 Copy of completed stamped mechanical plans 

 

	 	3.	 Certificate of Insurance naming as additional insured: contact Property manager for listing of additional
insureds 

  

	 	4.	 Copy of Contractor License 

 

	 	5.	 Schedule of work hours 

 

	 	6.	 Material safety date sheets for all products including but not limited to adhesives, cleaners, paints, oils and
items related to HVAC equipment. 

  

	 	7.	 Sign off by the property manager is required before work commences. 

Once the job is completed, the following is to be furnished to the Property Manager: 

 

	 	1.	 Copy of the Certificate of Occupancy 

 

	 	2.	 Completed “as built” drawings 

BUILDING MANAGEMENT
 Davis Management Co 

Senior Property Manager: Jason Biedrzycki 
 Office: (617) 451-1300 
 Cell: (603) 320-7594 

Assistant Property Manager: Ron Dorazio 
 Cell: (617) 875-5441 
 Chief Engineer: Doug Moulton 

Cell: (617) 592-0719 
  

							
	 Tenant

Acknowledged by:
	 	 	  	Date:	  	 
				
	 Contractor

Acknowledged by:
	 	 	  	Date:	  	 

 EXHIBIT 7.6.1.1 

XCHANGE AT BEDFORD 
 ENVIRONMENTAL
QUESTIONNAIRE 
 ENVIRONMENTAL QUESTIONNAIRE 

FOR COMMERCIAL AND INDUSTRIAL PROPERTIES 

Property Name: 

 

Property Address: 

 

Instructions: The following questionnaire is to be completed by the Lessee representative with knowledge of the planned
operations for the specified building/location. Please print clearly and attach additional sheets as necessary. 
  

	1.0	 PROCESS INFORMATION 

Describe planned use, and include brief description of manufacturing processes employed. 

 
  
  

 
  

 
  

	2.0	 HAZARDOUS MATERIALS 

Are hazardous materials used or stored? If so, continue with the next question. If not, go to Section 3.0. 

 

			
	 2.1  Are any of the following materials handled on the Property?
	  	Yes  No

 (A material is handled if it is used, generated, processed, produced, packaged, treated, stored, emitted,
discharged, or disposed.) If so, complete this section. If this question is not applicable, skip this section and go on to Section 5.0. 
  

							
	Explosives	  	Fuels	  	Oils	  	
	Solvents	  	Oxidizers	  	Organics/Inorganics	  	
	Acids	  	Bases	  	Pesticides	  	
	Gases	  	PCBs	  	Radioactive Materials	  	
	Other (please specify)	  		  		  	

  

	2-2.	 If any of the groups of materials checked in Section 2.1, please list the specific
material(s), use(s), and quantity of each chemical used or stored on the site in the Table below. If convenient, you may substitute a chemical inventory and list the uses of each of the chemicals in each category separately. 

 

																					
	 Material
	  	Physical State (Solid,
Liquid, or Gas)	 	  	Usage	 	  	Container
Size	 	  	Number of
Containers	 	  	Total
Quantity	 
		  				  				  				  				  			
		  				  				  				  				  			
		  				  				  				  				  			
		  				  				  				  				  			

																					
	 Material
	  	Physical State (Solid,
Liquid, or Gas)	 	  	Usage	 	  	Container
Size	 	  	Number of
Containers	 	  	Total
Quantity	 
		  				  				  				  				  			

  

	2-3.	 Describe the planned storage area location(s) for these materials. Please include site maps and drawings as
appropriate. 

  

	
	 
	 
	 

  

	3.0	 HAZARDOUS WASTES 

Are hazardous wastes
generated?                                        
                                         
                                         
                           Yes  No 

If yes, continue with the next question. If not, skip this section and go to Section 4.0. 

 

	3.1	 Are any of the following wastes generated, handled, or disposed of (where applicable) on the Property?

  

			
	Hazardous wastes	  	 Industrial Wastewater

	Waste oils	  	 PCBs

	Air emissions	  	 Sludges

	Regulated Wastes	  	 Other (please specify)

  

	3-2.	 List and quantify the materials identified in Question 3-1 of this
section. 

  

											
	 WASTE

GENERATED
	 	 RCRA

listed
 Waste?
	 	 SOURCE
	 	 APPROXIMATE

MONTHLY

QUANTITY
	 	 WASTE

CHARACTERIZATION
	 	 DISPOSITION

		 		 		 		 		 	
		 		 		 		 		 	
		 		 		 		 		 	
		 		 		 		 		 	

  

	3-3.	 Please include name, location, and permit number (e.g. EPA ID No.) for transporter and disposal facility, if
applicable). Attach separate pages as necessary. 

  

							
	 Transporter/Disposal Facility

Name
	 	 Facility

Location
	 	 Transporter (T) or Disposal (D)

Facility
	  	 Permit

Number

		 		 		  	
		 		 		  	
		 		 		  	
		 		 		  	

  

	3-4.	 Are pollution controls or monitoring employed in the process to prevent or minimize the release of wastes into
the environment?         Yes No 

	3-5.	 If so, please describe. 

 

	
	 
	 
	 

  

	4.0	 USTS/ASTS 

 

	4.1	 Are underground storage tanks (USTs), aboveground storage tanks (ASTs), or associated pipelines used for the
storage of petroleum products, chemicals, or liquid wastes present on site (lease renewals) or required for planned operations (new tenants)?     Yes     No    

 If not, continue with Section 5.0. If yes, please describe capacity, contents, age, type of the USTs or ASTs, as
well any associated leak detection/spill prevention measures. Please attach additional pages if necessary. 
  

															
	 Capacity
	  	Contents	 	  	Year
Installed	 	  	Type (Steel,
Fiberglass, etc.)	 	  	
Associated Leak Detection / Spill
Prevention Measures*

		  				  				  				  	
		  				  				  				  	
		  				  				  				  	

  

	*Note:	 The following are examples of leak detection / spill prevention measures: 

									
		 	Integrity testing	  	Inventory reconciliation	  	Leak detection system	  	
		 	Overfill spill protection	  	Secondary containment	  	Cathodic protection	  	

  

	4-2.	 Please provide copies of written tank integrity test results and/or monitoring documentation, if available.

  

							
	 4-3.
	 	Is the UST/AST registered and permitted with the appropriate regulatory agencies?	  	 	Yes  No	 
		 	  
 If so, please attach a copy of the required permits.
	  			

  

	4-4.	 If this Questionnaire is being completed for a lease renewal, and if any of the USTs/ASTs have leaked, please
state the substance released, the media(s) impacted (e.g., soil, water, asphalt, etc.), the actions taken, and all remedial responses to the incident. 

  

	
	 
	 
	 

  

					
	 4-5.
	 	If this Questionnaire is being completed for a lease renewal, have USTs/ASTs been removed from the Property?	  	Yes  No

 If yes, please provide any official closure letters or reports and supporting documentation (e.g., analytical
test results, remediation report results, etc.). 
  

							
	 4-6.
	 	For Lease renewals, are there any above or below ground pipelines on site used to transfer chemicals or wastes?	  	 	Yes  No	 

 For new tenants, are installations of this type required for the planned operations? 

Yes  No 

 If yes to either question, please describe. 

 

                          
                                         
                                         
                                         
                                         
                                         
                           
  

                          
                                         
                                         
                                         
                                         
                                         
                           
  

                          
                                         
                                         
                                         
                                         
                                         
                           
  

	5.0	 ASBESTOS CONTAINING BUILDING MATERIALS 

Please be advised that an asbestos survey may have been performed at the Property. If provided, please review the information that identifies the locations of
known asbestos containing material or presumed asbestos containing material. All personnel and appropriate subcontractors should be notified of the presence of these materials, and informed not to disturb these materials. Any activity that involves
the disturbance or removal of these materials must be done by an appropriately trained individual/contractor. 
  

	6.0	 REGULATORY 

 

	6-1.	 Does the operation have or require a National Pollutant Discharge Elimination System (NPDES) or equivalent
permit?     Yes No 

  

	    	 If so, please attach a copy of this permit. 

 

	6-2.	 Has a Hazardous Materials Business Plan been developed for the site?    Yes No

  

	    	 If so, please attach a copy. 

CERTIFICATION 
 Lessee understands that Lessor will rely
on the completeness and accuracy of these answers in assessing any environmental liability risks associated with the property. 
  

			
	KALEIDO BIOSCIENCES, INC.
		
	By:	 	  

		
	Name:	 	  

		
	Title:	 	  

		
	Date:	 	  

		
	Telephone:	 	  

 EXHIBIT 8.5 

SURRENDER OBLIGATION SPECIFICATIONS 

Communications Equipment 
  

	 	a.	 Tenant shall not be obligated to remove any office voice and data cabling, to include patch panels in
the server room and phone closet. 

  

	 	b.	 Tenant shall remove all voice and data switches, network appliances, wireless access points, computers
and servers. 

 HVAC System, Fans and Air Processing Equipment 

 

	 	a.	 Tenant shall not remove the HVAC System, Fans and Air Processing Equipment. 

 

	 	b.	 Tenant shall not remove the rooftop heaters and air conditioners provided for and managed by Landlord.

  

	 	c.	 Tenant shall not remove the two Strobic fan units 

 

	 	d.	 Tenant shall not remove Split systems and Ductless units in the labs. 

 

	 	e.	 Tenant shall not remove the gas-fired boilers.

  

	 	f.	 Tenant shall not remove the two Water Heaters in the Main Mechanical Room 

 

	 	g.	 Tenant shall not remove the Building Automation System. 

Miscellaneous Equipment 
  

	 	a.	 Tenant shall not remove the central Glasswash. 

 

	 	b.	 Tenant shall not remove the Autoclave system. 

 

	 	c.	 Tenant shall not remove pH Neutralization System. 

 

	 	d.	 Tenant shall not remove the Casework & Fume Hoods. 

 

	 	e.	 Tenant shall not remove the Compressed Air System. 

 

	 	f.	 Tenant shall not remove the Vacuum System. 

With respect to any of the items set forth above that Tenant “shall remove,” Landlord, at its election, may provide Tenant written notice no
later than thirty (30) days’ prior to the Expiration Date that Landlord has changed its designation of the disposition of such items and, therefore, Tenant “shall not remove” such items. 

 EXHIBIT 14.1 

FORM OF SNDA 

SUBORDINATION, NON-DISTURBANCE 

AND ATTORNMENT AGREEMENT 

This Subordination, Non-Disturbance and Attornment Agreement made on
                    , 2017, by and among Landlord, Tenant and Lender, all as hereinafter defined; 

W I T N E S S E T H:

 IN CONSIDERATION OF TEN AND NO/100 ($10.00) DOLLARS and other good and valuable consideration, the receipt and sufficiency of which
are hereby acknowledged, the undersigned Landlord, Tenant and Lender hereby covenant and agree as follows: 
 1.     For
purposes of this Agreement the following terms shall be defined as set forth below: 
 A.    Assignment of Leases:
That certain Assignment of Leases and Rents affecting Landlord’s interest in the Lease executed by Landlord in favor of Lender and recorded in the Middlesex South District Registry of Deeds (the “Registry”) in Book 59113, Page 426 and
filed with the Middlesex South Registry District of the Land Court (the “Registry District”) as Document No. 01601091. 

B.    Mortgage: That certain Mortgage, Assignment of Rents and Leases, Security Agreement and Fixture Filing to be
executed by Landlord in favor of Lender, conveying Landlord’s interest in the Property to Lender and recorded in the Registry in Book 59113, Page 397 and filed with the Registry District as Document No. 01601090 (included in the term are
all amendments, additions and substitutions thereof). 
 C.    Landlord: DIV Bedford, LLC, a Massachusetts limited
liability company. 
 D.    Lease: That certain Lease by and between Landlord and Tenant dated June
    , 2017, affecting a portion of the Property, consisting of the leasable area of the building located at and known as 18 Crosby Drive, Bedford, Massachusetts. 

E.    Property: All that tract or parcel of land lying and being in Middlesex County, Massachusetts, as more particularly
described on Exhibit “A” attached hereto and made a part hereof. 
 F.    Tenant: Kaleido BioSciences, Inc. a
Delaware corporation 
 G.    Lender: Santander Bank, N.A., successor in interest to Sovereign Bank, N.A. 

H.    Lender’s Address:
                                         
                                        

2.    Tenant has subordinated and does hereby subordinate all of its rights in and to the Property and in and to the Lease
(including any options to purchase) to the lien of the following: (i) the Mortgage; (ii) any, and all renewals, substitutions, extensions, modifications, replacements or amendments of the Mortgage; (iii) all loan documents executed in
connection with the Mortgage including, without limitation, the Assignment of Leases; and (iv) all indebtedness secured by the Mortgage and all advances made pursuant thereto prior to or after the date hereof. Notwithstanding anything to the
contrary contained herein or in the Lease, any interest of Tenant in any right of first refusal contained in the Lease shall not be binding upon Lender at a foreclosure sale of the Property, upon any purchaser at a foreclosure sale of the Property
or upon a transfer of the Property by Lender by deed in lieu of foreclosure. 

 3.    Tenant shall give written notice to Lender (at its address set
forth above) of any default of Landlord under the Lease (at the time and in the same manner it gives said notice to Landlord) and agrees that Lender shall have the time periods set forth in the Lease for cure to cure said Landlord default. 

4.    So long as Tenant is not in default under the Lease beyond the expiration of applicable notice and cure periods in
the payment of rent or additional rent or in the performance of any of the terms, or conditions of the Lease, Lender covenants and agrees that possession of the demised premises under the Lease and the rights and privileges of Tenant under the Lease
shall not be diminished or interfered with by the Lender in the exercise of any of its rights under the Mortgage. 

5.    If Lender, its successors or assigns shall succeed to the interest of Landlord under the Lease in any manner, or if
any other person or entity shall acquire Landlord’s interest in the Property upon any foreclosure of the Mortgage (Lender, its successors or assigns, or such other person or entity, as the case may be, being hereinafter referred to as
“Successor Landlord”), Tenant shall attorn to Successor Landlord upon such succession or foreclosure sale and shall recognize Successor Landlord as the landlord under the Lease, and the Lease shall remain in full force and effect and shall
inure to the benefit of Successor Landlord as landlord thereunder. Such attornment shall be effective and self-operative without the execution of any further instrument. Tenant agrees, however, to execute and deliver at any time and from time to
time, upon the request of Successor Landlord, any instrument or certificate that may be necessary or appropriate to evidence such attornment. From and after any such attornment, Successor Landlord shall be bound to Tenant under all the terms,
covenants and conditions of the Lease, except that Successor Landlord shall not (a) be liable for any act or omission of any prior landlord (including Landlord), except that, so long as Tenant has given notice to Lender pursuant to Section 3 hereof
with respect to a default of a prior landlord in the performance of its obligations under the Lease, Successor Landlord shall be bound to perform such obligations; or (b) be subject to any offset or defenses which Tenant might have against any prior
landlord (including Landlord), except such offset rights and defenses as are expressly set forth in the Lease with respect to any default by Landlord as to which Tenant had given notice to Lender pursuant to Section 3 hereof, which default remains
uncured; or (c) be bound by any rent or additional rent which Tenant might have paid for more than sixty (60) days in advance to any prior landlord (including Landlord); or (d) be bound by any amendment or modification of the Lease made without the
consent of Lender. 
 6.    This Agreement shall bind and inure to the benefit of successors in interest of the parties
hereto. 
 7.    This Agreement shall be governed by the laws of The Commonwealth of Massachusetts. 

[signature page follows] 

 IN WITNESS WHEREOF, the undersigned Tenant has hereunto caused this Agreement to be executed
by its duly authorized corporate officials and its corporate seal to be affixed hereto as of the day and year first above written. 
  

	
	 TENANT:
  

	KALEIDO BIOSCIENCES, INC.,
	 a Delaware corporation
  

By:
                                         
                                   

	Name:                                     
                                   
	Its:                                     
                                         

 COMMONWEALTH OF MASSACHUSETTS 

                          
          , ss. 
 On this      day of June, 2017, before me, the
undersigned notary public, personally appeared                              proved to me through
satisfactory evidence of identification, which was                             , to be the
person whose name is signed on the preceding or attached document, and acknowledged to me that he signed it voluntarily for its stated purposes as said
                             of the
                            . 

                    
        , Notary Public 
 My commission expires: 

(SNDA) 

 
			
	LANDLORD:
	
	 DIV BEDFORD, LLC, a Massachusetts

limited liability company

 
			
		
	By:	 	  

	Name:	 	  

	Its:	 	  

 STATE OF/COMMONWEALTH OF
                                        

                          
                      , ss. 
 On this
             day of June, 2017, before me, the undersigned notary public, personally appeared
                                 proved to me through satisfactory evidence of
identification, which was
                                    , to be the person whose
name is signed on the preceding or attached document, and acknowledged to me that he signed it voluntarily for its stated purposes as
said                                      of the
                                    . 

                    
                    , Notary Public 

My commission expires: 
 (SNDA)

 
	
	 LENDER:

	
	 SANTANDER BANK, N.A.

	
	
By:                  
                                         

	
Name:                  
                            

	
Its:                  
                                  

 STATE OF/COMMONWEALTH OF
                                     

                          
      , ss. 
 On this      day of June, 2017, before me, the undersigned notary public,
personally appeared                                  proved to me through
satisfactory evidence of identification, which was
                                , to be the person whose name is signed on the
preceding or attached document, and acknowledged to me that he signed it voluntarily for its stated purposes as said
                                 of Santander Bank, N.A. 

                       
     , Notary Public 
 My commission expires: 

(SNDA) 

 EXHIBIT 14.4 

FORM OF ESTOPPEL 
 Form
of Tenant Estoppel Certificate 
 The undersigned (“Tenant”) hereby certifies to
                     and
                     (collectively, the “Recipients”), as of the date hereof, as follows: 

1. Lease. Tenant is the current tenant under that certain Lease dated
                            , 20     (the “Original Lease”) by
and between                                     
(“Landlord”) and Tenant, pursuant to which Tenant leases approximately              square feet (the “Premises”) in the building located at
                             (the “Building”). 

2. No Modifications. The Original Lease has not been modified, changed, altered, supplemented, amended or terminated in any respect,
except as indicated below (if none, please state “none”; the Original Lease, as modified, changed, altered, supplemented or amended as indicated below, is referred to collectively as the “Lease”): 

 

			
	 	 	
	 	 	
	 	 	
	 	 	

 3. Copy. A true, correct and complete copy of the Lease is attached hereto. 

4. Validity. The Lease represents the valid and binding obligation of Tenant in accordance with its terms and is in full force and
effect on the date hereof. The Lease represents the entire agreement and understanding between Landlord and Tenant with respect to the Premises, the Building and the land on which the Building is situated. Except as expressly set forth in the Lease,
Tenant has no right under the Lease to terminate all or any portion of the Lease. 
 5. No Concessions. Except as set forth in the
Lease, Tenant is not entitled to, and has made no agreement with Landlord or its agents or employees concerning, free rent, partial rent, rebate of rent payments, credit or offset or reduction in rent, or any other type of rental concession
including, without limitation, lease support payments, lease buy-outs, or assumption of any leasing or occupancy agreements of Tenant. 
 6.
Term. Except for
                                         
                   , all conditions precedent to the commencement of the initial term of the Lease have been fully satisfied or waived. The initial
term of the Lease began on                     , 20    . The expiration date of the present term of the Lease,
excluding unexercised renewal terms, is                     , 20    , or, if the commencement date has not yet been
set,          months after the commencement date. [IF TRUE: The commencement date has occurred and Tenant has accepted possession of and currently occupies the Premises. Tenant has not sublet all or any
portion of the Premises to any sublessee, has not assigned, transferred, mortgaged, hypothecated or otherwise encumbered any of its rights or interests under the Lease and has not entered into any license or concession agreements with respect
thereto, except for the following in accordance with the Lease:
                                         
                   . 

 7.    Options. Except as set forth in the Lease, Tenant has no
outstanding options or rights to renew or extend the term of the Lease, or expansion options, or cancellation options, rights of first refusal, or rights of first offer to lease other space within the Building. Tenant has no outstanding options,
rights of first refusal or rights of first offer to purchase the Premises or any part thereof or all or any part of the Building and/or the land on which the Building is situated. 

8.    Rents. The obligation to pay rent began (or begins) on
                                , 20
        . The current monthly base rent payable under the Leases is
$                            . The monthly base rental payment (excluding pass through charges) has
been paid through the month of                             ,
                . Tenant is also obligated to pay its proportionate share of ad valorem taxes, insurance and operating expenses on the Building, to the extent
provided in the Lease. Tenant’s estimated share of ad valorem taxes, insurance and operating expenses on the Building has been paid by Tenant through
                                ,
                . Except for payments of its estimated share of ad valorem taxes, insurance and operating expenses being paid in accordance with the Lease, no
rent (excluding security deposits described in Paragraph 9 below) has been paid more than one (1) month in advance of its due date. 

9.    Security Deposits. Tenant’s security deposit, if any, which has been previously deposited with Landlord
is $                                 (if none, please state “none”). The
security deposit                  is, or                  is not,
represented by a letter of credit. 
 10.    No Default. To the best of Tenant’s knowledge, no event has
occurred and no condition exists that constitutes, or that with the giving of notice or the lapse of time or both, would constitute, a default by Landlord or, to the best knowledge of Tenant, Tenant under the Lease except
                    . To the best knowledge of Tenant, Tenant has no existing claims against Landlord or defenses to the enforcement of the
Lease by Landlord and Tenant is not currently entitled to any rent abatements or offsets against the rents owing under the Lease except
                         

11.    Allowances. All required allowances, contributions or payments (whether or not currently due and payable) by
Landlord to Tenant on account of Tenant’s tenant improvements have been received by Tenant and all of Tenant’s tenant improvements have been completed in accordance with the terms of the Lease, except as indicated below (if none, please
state “none”): 
  

	
	     

	     

	     

	     

 To the best knowledge of Tenant, Tenant’s current use and operation of the Premises complies with all covenants and
operating requirements in the Lease. 
 12.    No Bankruptcy Proceedings. No voluntary actions or, to
Tenant’s best knowledge, involuntary actions are pending against Tenant under the bankruptcy, insolvency, or reorganization laws of the United States or any state thereof. 

13.    Environmental Matters. Tenant has received no notice by any governmental authority or person claiming a
violation of, or requiring compliance with, any federal, state or local statute, ordinance, rule, regulation or other requirement of law, for environmental contamination at the Premises and no hazardous, toxic or polluting substances or wastes have
been generated, treated, manufactured, stored, refined, used, handled, transported, released, spilled, disposed of or deposited on, in or under the Premises, except
                                . 

 14.    Address. The current address for notices to be sent to
Tenant under the Lease is set forth below. 
 15.    Reliance. Tenant acknowledges that the Recipients have or
will hereafter acquire an interest in the Landlord or the Property and/or loan money to the Landlord in connection with the Property, and that the Recipients are relying upon this Tenant’s Estoppel Certificate in connection therewith. Tenant
further acknowledges that this Tenant’s Estoppel Certificate may be relied upon by, and inures to the benefit of, the Recipients and each of their respective partners, successors and assigns. 

16.    Authority. The undersigned is duly authorized to execute this Tenant’s Estoppel Certificate on behalf
of Tenant. 
 17.    Accuracy. The information contained in this Tenant’s Estoppel Certificate is true,
correct and complete as of the date below written. 
 Executed as of the          day of
        ,         . 
  

			
	TENANT:
		
	By:	 	  

		 	Name:
		 	Title:
	
	Tenant’s Current Address for Notices:Form of Senior Debt Indenture

Table of Contents

 Exhibit 4.3 

 
 NOMURA HOLDINGS, INC. 

as the Company 
 and 

CITIBANK, N.A. 
 as the
Trustee 
 SENIOR DEBT INDENTURE 

Dated as of [            ] 

Table of Contents

 TABLE OF CONTENTS 

 

					
		
		  	 	Page	 
	ARTICLE 1	  			
	DEFINITIONS	  			
		
	Section 1.01. Certain Terms Defined 	  	 	1	 
		
	ARTICLE 2	  			
	SECURITIES	  			
	Section 2.01. Forms Generally	  	 	5	 
	Section 2.02. Form of Trustee’s Certification of Authentication	  	 	6	 
	Section 2.03. Amount Unlimited; Issuable in Series	  	 	6	 
	Section 2.04. Authentication and Delivery of Securities	  	 	9	 
	Section 2.05. Execution of Securities	  	 	9	 
	Section 2.06. Certificate of Authentication	  	 	10	 
	Section 2.07. Form, Denomination and Date of Securities; Payments of Interest	  	 	10	 
	Section 2.08. Registration, Transfer and Exchange of Securities	  	 	10	 
	Section 2.09. Mutilated, Defaced, Destroyed, Lost and Stolen Securities	  	 	12	 
	Section 2.10. Cancellation of Securities	  	 	13	 
	Section 2.11. Temporary Securities	  	 	13	 
	Section 2.12. Japanese Withholding Tax	  	 	13	 
	Section 2.13. CUSIP, ISIN Numbers and Common Codes	  	 	14	 
		
	ARTICLE 3	  			
	COVENANTS OF THE COMPANY	  			
	Section 3.01. Payment of Principal and Interest	  	 	14	 
	Section 3.02. Offices for Payments, etc.	  	 	15	 
	Section 3.03. Appointment to Fill a Vacancy in Office of Trustee	  	 	15	 
	Section 3.04. Paying Agents	  	 	15	 
	Section 3.05. Additional Amounts	  	 	16	 
	Section 3.06. Certificate of the Company	  	 	18	 
	Section 3.07. Securityholders Lists	  	 	18	 
	Section 3.08. Statement by Officers as to Default	  	 	18	 
	Section 3.09. Reports by the Company	  	 	18	 
	Section 3.10. Notices to Holders	  	 	19	 
		
	 ARTICLE 4

REMEDIES OF THE TRUSTEE AND SECURITYHOLDERS ON EVENT OF DEFAULT
	  			
	Section 4.01. Event of Default, Acceleration of Maturity, Waiver of Default	  	 	19	 
	Section 4.02. Collection of Indebtedness by Trustee; Trustee May File Proof of Claim	  	 	20	 
	Section 4.03. Application of Proceeds	  	 	22	 
	Section 4.04. Suits for Enforcement	  	 	23	 
	Section 4.05. Restoration of Rights on Abandonment of Proceeding	  	 	23	 
	Section 4.06. Limitations on Suits by Securityholders	  	 	23	 
	Section 4.07. Unconditional Right of Securityholders to Institute Certain Suits	  	 	23	 
	Section 4.08. Powers and Remedies Cumulative; Delay or Omission Not Waiver of Default	  	 	23	 
	Section 4.09. Control by Securityholders	  	 	24	 
	Section 4.10. Waiver of Past Defaults	  	 	24	 

  
 i 

Table of Contents

					
	Section 4.11. Trustee to Give Notice of Default	  	 	24	 
	Section 4.12. Right of Court to Require Filing of Undertaking to Pay Costs	  	 	24	 
	Section 4.13. Judgment Currency 	  	 	25	 
		
	 ARTICLE 5

CONCERNING THE TRUSTEE
	  			
	Section 5.01. Duties and Responsibilities of the Trustee; During Default; Prior to Default	  	 	25	 
	Section 5.02. Certain Rights of the Trustee	  	 	26	 
	 Section 5.03. 
Trustee Not Responsible for Recitals, Disposition of Securities or Application of Proceeds Thereof
	  	 	29	 
	Section 5.04. Trustee and Agents May Hold Securities; Collections, etc.	  	 	29	 
	Section 5.05. Moneys Held by Trustee	  	 	29	 
	Section 5.06. Compensation and Indemnification of Trustee and its Prior Claim	  	 	30	 
	Section 5.07. Right of Trustee to Rely on Officer’s Certificate, etc.	  	 	30	 
	Section 5.08. Persons Eligible for Appointment as Trustee	  	 	31	 
	Section 5.09. Resignation and Removal; Appointment of Successor Trustee	  	 	31	 
	Section 5.10. Acceptance of Appointment by Successor Trustee	  	 	32	 
	Section 5.11. Merger, Conversion, Consolidation or Succession to Business of Trustee	  	 	33	 
	Section 5.12. Conflicting Interests	  	 	33	 
	Section 5.13. Appointment of Authenticating Agent	  	 	33	 
	Section 5.14. Reports by the Trustee	  	 	34	 
		
	 ARTICLE 6

CONCERNING THE SECURITYHOLDERS
	  			
	Section 6.01. Evidence of Action Taken by Securityholders	  	 	34	 
	Section 6.02. Proof of Execution of Instruments and of Holding of Securities; Record Date	  	 	35	 
	Section 6.03. Holders to be Treated as Owners	  	 	35	 
	Section 6.04. Securities Owned by Company Deemed Not Outstanding	  	 	35	 
	Section 6.05. Right of Revocation of Action Taken	  	 	36	 
		
	ARTICLE 7	  			
	SUPPLEMENTAL INDENTURES	  			
	Section 7.01. Supplemental Indentures Without Consent of Securityholders	  	 	36	 
	Section 7.02. Supplemental Indentures With Consent of Securityholders	  	 	37	 
	Section 7.03. Effect of Supplemental Indenture	  	 	38	 
	Section 7.04. Documents to be Given to Trustee	  	 	38	 
	Section 7.05. Notation on Securities in Respect of Supplemental Indentures	  	 	39	 
	Section 7.06. Conformity with the Trust Indenture Act	  	 	39	 
		
	ARTICLE 8	  			
	CONSOLIDATION, MERGER, SALE OR CONVEYANCE	  			
	Section 8.01. Company May Consolidate, etc., on Certain Terms	  	 	39	 
	Section 8.02. Successor Substituted	  	 	39	 
	Section 8.03. Opinion of Counsel to Trustee	  	 	40	 

  
 ii 

Table of Contents

					
	 ARTICLE 9
	  			
	 SATISFACTION AND DISCHARGE OF INDENTURE; UNCLAIMED MONEYS
	  			
	Section 9.01. Satisfaction and Discharge of Indenture	  	 	40	 
	Section 9.02. Application by Trustee of Funds Deposited for Payment of Securities	  	 	40	 
	Section 9.03. Repayment of Moneys Held by Paying Agent	  	 	40	 
	Section 9.04. Return of Moneys Held by Trustee and Paying Agent Unclaimed for Two Years	  	 	40	 
		
	ARTICLE 10	  			
	MISCELLANEOUS PROVISIONS	  			
	 Section 10.01. 
Incorporators, Stockholders, Officers and Directors of Company Exempt from Individual Liability
	  	 	41	 
	 Section 10.02. 
Provisions of Indenture for the Sole Benefit of Parties and Securityholders
	  	 	41	 
	 Section 10.03. 
Successors and Assigns of Company Bound by Indenture
	  	 	41	 
	 Section 10.04. 
Notices and Demands on Company, Trustee and Securityholders
	  	 	41	 
	 Section 10.05. 
Officer’s Certificates and Opinions of Counsel; Statements to be Contained Therein
	  	 	42	 
	 Section 10.06. 
Conflict of any Provision of Indenture with Trust Indenture Act
	  	 	43	 
	 Section 10.07. New York Law to Govern
	  	 	43	 
	 Section 10.08. Counterparts
	  	 	43	 
	 Section 10.09. Effect of Headings
	  	 	43	 
	 Section 10.10. Submission To Jurisdiction
	  	 	43	 
	 Section 10.11. 
Non-Business Day
	  	 	43	 
	 Section 10.12. Waiver of Jury Trial
	  	 	44	 
	 Section 10.13. Patriot Act
	  	 	44	 
		
	ARTICLE 11	  			
	REDEMPTION AND REPURCHASE OF SECURITIES	  			
	 Section 11.01. Applicability of Article
	  	 	44	 
	 Section 11.02. 
Optional Redemption Due to Changes in Tax Treatment
	  	 	44	 
	 Section 11.03. Notice of Redemption
	  	 	44	 
	 Section 11.04. Payment of Securities Called for
Redemption
	  	 	45	 
	 Section 11.05. 
Exclusion of Certain Securities from Eligibility for Selection for Redemption
	  	 	46	 
	 Section 11.06. Repurchase of Securities
	  	 	46	 
		
	 EXHIBITS
	  	 	    	 
		
	 Exhibit A Form of Officer’s Certificate pursuant to Section 
3.06
	  	 	A-1	 

  
 iii 

Table of Contents

 CROSS REFERENCE SHEET 

Cross-reference sheet of provisions of the Trust Indenture Act this indenture: 
  

			
	 Section of the Act
	  	Section of Indenture
	 310(a)(1) and (2)
	  	5.08
	 310(a)(3) and (4)
	  	Inapplicable
	 310(a)(5)
	  	Incorporated by Section 318(c)
	 310(b)
	  	5.09
	 311(a) and (b)
	  	Incorporated by Section 318(c)
	 312(a)
	  	3.07
	 312(b)
	  	Incorporated by Section 318(c)
	 312(c)
	  	Incorporated by Section 318(c)
	 313(a)
	  	5.14
	 313(b)(1)
	  	Inapplicable
	 313(b)(2)
	  	Incorporated by Section 318(c)
	 313(c)
	  	Incorporated by Section 318(c)
	 313(d)
	  	Incorporated by Section 318(c)
	 314(a)
	  	3.09
	 314(b)
	  	Inapplicable
	 314(c)(1) and (2)
	  	10.05
	 314(c)(3)
	  	Inapplicable
	 314(d)
	  	Inapplicable
	 314(e)
	  	10.05
	 315(a), (c) and (d)
	  	5.01
	 315(b)
	  	4.11
	 315(e)
	  	4.12
	 316(a)(1)
	  	4.09
	 316(a)(2)
	  	Inapplicable
	 316(b)
	  	4.07
	 316(c)
	  	Incorporated by Section 318(c)
	 317(a)
	  	4.02
	 317(b)
	  	3.04
	 318(a)
	  	10.06

 Notes: 
 This cross-reference
sheet shall not, for any purpose, be deemed to be a part of this Indenture. 
 Attention should also be directed to Section 318(c) of the Trust
Indenture Act, which provides that the provisions of Sections 310 to and including 317 of the Trust Indenture Act are a part of and govern every qualified indenture, whether or not physically contained therein. Sections designated in the
cross-reference sheet above as “Incorporated by Section 318(c)” are not physically contained herein but are incorporated in this Indenture automatically by Section 318(c) of the Trust Indenture Act. 

  
 iv 

Table of Contents

 THIS INDENTURE, dated as of
[            ] between Nomura Holdings, Inc., a joint stock corporation with limited liability under the laws of Japan (the “Company”), and Citibank, N.A. (the
“Trustee”). 
 W I T N E S S E T H: 

WHEREAS, the Company has duly authorized the issue from time to time of its unsecured debentures, notes or other evidences of indebtedness to
be issued in one or more series (the “Securities”) up to such principal amount or amounts as may from time to time be authorized in accordance with the terms of this Indenture, and to provide, among other things, for the
authentication, delivery and administration thereof, the Company has duly authorized the execution and delivery of this Indenture; and 

WHEREAS, all things necessary to make this Indenture a valid indenture and agreement according to its terms have been done; 

NOW, THEREFORE: 
 In
consideration of the premises and the purchases of the Securities by the holders thereof, the Company and the Trustee mutually covenant and agree for the equal and proportionate benefit of the respective holders from time to time of the Securities
as follows: 
 ARTICLE 1 

DEFINITIONS 
 
Section 1.01. Certain Terms Defined. The following terms (except as otherwise expressly provided herein or in the form of Security or any indenture supplemental hereto, or unless the context otherwise clearly requires)
for all purposes of this Indenture and of any indenture supplemental hereto shall have the respective meanings specified in this Section. All other terms used in this Indenture that are defined in the Trust Indenture Act or the definitions of which
contained in the Securities Act are referred to in the Trust Indenture Act, including terms defined in the Trust Indenture Act by reference to the Securities Act (except as herein otherwise expressly provided or unless the context otherwise clearly
requires), shall have the meanings assigned to such terms in said Trust Indenture Act and in said Securities Act as in force at the date of this Indenture. All accounting terms used herein and not expressly defined shall have the meanings assigned
to such terms in accordance with generally accepted accounting principles, and the term “generally accepted accounting principles” means such accounting principles as are generally accepted in the United States of America at the
time of any computation. The words “herein,” “hereof” and “hereunder” and other words of similar import refer to this Indenture as a whole and not to any particular Article, Section or other
subdivision. The terms defined in this Article have the meanings assigned to them in this Article and include the plural as well as the singular. 

“Additional Amounts” has the meaning set forth in Section 3.05. 

“Authenticating Agent” means any Person authorized by the Trustee pursuant to Section 5.13 to act on behalf of the
Trustee to authenticate the Securities. 
 “Authorized Agent” has the meaning set forth in Section 10.10. 

“Bankruptcy Act” has the meaning set forth in Section 4.01(d). 

“Board” means the Board of Directors of the Company or any duly authorized committee of such Board or any director(s),
executive officer(s) or officer(s), or combination thereof, of the Company to whom such Board of Directors or duly authorized committee thereof or duly delegated director or executive officer thereof has duly delegated its authority. 

  
 1 

Table of Contents

 “Board Resolution” means one or more resolutions or determinations to have
been duly adopted or consented to by the Board and to be in full force and effect. 
 “Business Day” means, with respect
to any Security, a day that in the city of the Corporate Trust Office of the Trustee, and in The City of New York, Tokyo or any city (or in any of the cities, if more than one) in which amounts are payable, as specified in the form of such Security,
and in any other city specified in an indenture supplemental hereto or in the form of such Security, is not a day on which banking institutions are authorized by law or regulation to close. 

“Civil Rehabilitation Act” has the meaning set forth in Section 4.01(d). 

“Clearing Organization” means, with respect to the Securities of any series issuable or issued in the form of one or more
Registered Global Securities, the Person designated as Clearing Organization by the Company pursuant to Section 2.03 until a successor Clearing Organization shall have become such pursuant to the applicable provisions of this Indenture, and
thereafter “Clearing Organization” shall mean or include each Person who is then a Clearing Organization hereunder, and if at any time there is more than one such Person, “Clearing Organization” as used with respect to the
Securities of any such series shall mean the Clearing Organization with respect to the Registered Global Securities of that series. 

“Commission” means the U.S. Securities and Exchange Commission, as from time to time constituted, created under the Exchange
Act, or if at any time after the execution and delivery of this Senior Debt Indenture such Commission is not existing and performing the duties now assigned to it under the Trust Indenture Act, then the body performing such duties on such date. 

“Companies Act” has the meaning set forth in Section 4.01(d). 

“Company” means Nomura Holdings, Inc., and, subject to Article 8, its successors and assigns. 

“Corporate Reorganization Act” has the meaning set forth in Section 4.01(d). 

“Corporate Trust Office” means the office of the Trustee at which the corporate trust business of the Trustee in the United
States shall, at any particular time, be principally administered, which office is, at the date as of which this Indenture is dated, located at (a) solely for purposes of the transfer, exchange or surrender of the Notes, 480 Washington Boulevard,
30th Floor, Jersey City, New Jersey 07310, Attention: Agency & Trust (Nomura Holdings, Inc.), and (b) for all other purposes, 388 Greenwich Street, New York, New York 10013, Attention: Agency & Trust (Nomura Holdings, Inc.), Facsimile: +1 (347) 632-8640, or such other address as is referenced in Section 10.04 herein; or as the Trustee may designate from time to time by notice to the Holders and the Company, or the principal
corporate trust office of any successor trustee (or such other address as such successor trustee may designate from time to time by notice to the Holders and the Company). 

“Depositary” means, with respect to the Registered Global Securities, DTC or such other Person as shall be designated as
Depositary by the Company pursuant to the last sentence of Section 2.07(a). 
 “Designated Financial Institution” has
the meaning set forth in Section 3.05. 
 “Dollar”, “$” or “U.S. dollar” means the
coin or currency of the United States of America that at the time of payment is legal tender for the payment of public and private debts. 

“DTC” means The Depository Trust Company, its nominees, and their respective successors. 

“DTC Procedures” has the meaning set forth in Section 2.12(a). 

  
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 “Event of Default” means any event or condition specified as such in
Section 4.01. 
 “Exchange Act” means the United States Securities Exchange Act of 1934, as amended. 

“Expiration Date” has the meaning set forth in Section 6.02. 

“FATCA” has the meaning set forth in Section 3.05. 

“Financial Instruments and Exchange Act” has the meaning set forth in Section 11.02. 

“FSA” means the Financial Services Agency of Japan or any successor or similar authority. 

“Holder,” “holder of Securities,” “Securityholder” or other similar terms mean the holder
of any Security. 
 “Incorporated Provision” has the meaning set forth in Section 10.06. 

“Indenture” means this instrument as originally executed and delivered or, if amended or supplemented as herein provided, as
so amended or supplemented or both, and shall include the forms and terms of particular series of Securities established as contemplated hereunder. 

“interest” means, when used with respect to non-interest bearing Securities,
interest payable after maturity. 
 “Interest Recipient Information” has the meaning set forth in Section 3.05. 

“Japanese Taxes” has the meaning set forth in Section 3.05. 

“Judgment Currency” has the meaning set forth in Section 4.13. 

“New York Banking Day” has the meaning set forth in Section 4.13. 

“Notice of Default” has the meaning set forth in Section 4.01(b). 

“Officer’s Certificate” means a certificate signed by any one Responsible Officer of the Company authorized by the
Board or a Representative Executive Officer to execute any such certificate. Each such certificate shall comply with Section 314 of the Trust Indenture Act and include the statements provided for in Section 10.05. 

“Opinion of Counsel” means an opinion in writing signed by legal counsel reasonably acceptable to the Trustee, who may be
counsel to the Company, and which opinion shall be in form and substance reasonably satisfactory to the Trustee. Each such opinion shall comply with Section 314 of the Trust Indenture Act and include the statements provided for in
Section 10.05, if and to the extent required hereby. 
 “Original Issue Discount Security” means any Security that
provides for an amount less than the principal amount thereof to be due and payable upon a declaration of acceleration of the maturity thereof pursuant to Section 4.01. 

“Outstanding” when used with reference to Securities, shall, subject to the provisions of Section 6.04, mean, as of any
particular time, all Securities authenticated and delivered by the Trustee under this Indenture, except: 

(a)        Securities theretofore cancelled by the Trustee or accepted by the Trustee for
cancellation; 

  
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 (b)        Securities for whose payment or
redemption money in the necessary amount has been theretofore deposited with the Trustee or any Paying Agent (other than the Company) in trust or set aside and segregated in trust by the Company (if the Company shall act as its own Paying Agent) for
the Holders of such Securities; provided that, if such Securities are to be redeemed prior to the stated maturity thereof, notice of such redemption has been duly given pursuant to this Indenture or provision therefor satisfactory to the Trustee has
been made; 
 (c)        Securities in substitution for which other Securities shall have been
authenticated and delivered, or which shall have been paid, pursuant to the terms of Section 2.09 (except with respect to any such Security as to which proof satisfactory to the Trustee is presented that such Security is held by a Person in
whose hands such Security is a legal, valid and binding obligation of the Company); or 

(d)        Securities owned by the Company or one of its affiliates. 

In determining whether the holders of the requisite principal amount of Outstanding Securities of any or all series have given any request,
demand, authorization, direction, notice, consent or waiver hereunder, the principal amount of an Original Issue Discount Security that shall be deemed to be Outstanding for such purposes shall be the amount of the principal thereof that would be
due and payable as of the date of such determination upon a declaration of acceleration of the maturity thereof pursuant to Section 4.01. 

“Participant” has the meaning set forth in Section 3.05. 

“Paying Agent” means the paying agent appointed by the Company as paying agent and/or transfer agent for the Securities or
any series thereof. 
 “Person” means any individual, corporation, limited liability company, partnership, joint venture,
association, joint stock company, trust, unincorporated organization or government or any agency or political sub-division thereof or other entity, whether or not having a separate legal personality. 

“Place of Payment” when used with respect to the Securities of any particular series, means the place or places where the
principal of and interest, if any, on the Securities of that series are payable, as contemplated in Section 2.03(j). 

“Principal” whenever used with reference to the Securities or any Security or any portion thereof, shall be deemed to
include “and premium, if any.” For the avoidance of doubt, “premium” referred to in the previous sentence means amounts exceeding the face value of a Security payable by the Company to the Holders upon redemption or such other
event provided for in a supplemental indenture or in a form of Security. 
 “record date” has the meaning set forth in
Section 2.07(c). 
 “Register” has the meaning set forth in Section 2.08(a). 

“Registered Global Security” means a Security evidencing all or a part of a series of Registered Securities, issued to the
Clearing Organization for such series in accordance with Section 2.03 and bearing the legend prescribed by any applicable form of Security or any supplemental indenture. 

“Registered Security” means any Security registered on the Register. 

“Registrar” has the meaning set forth in Section 2.08(a). 

“Required Currency” has the meaning set forth in Section 4.13. 

  
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 “Responsible Officer” when used with respect to the Trustee means any
managing director, vice president, trust associate, relationship manager, transaction manager, client service manager, any trust officer or any other officer located at the Corporate Trust Office of the Trustee who customarily performs functions
similar to those performed by any persons who at the time shall be such officers, respectively, or to whom any corporate trust matter is referred because of such person’s knowledge of and familiarity with the particular subject and in each such
case, who shall have direct responsibility for the day to day administration of this Indenture. When used with respect to the Company, “Responsible Officer” means the President, the Deputy President, the Chief Financial Officer or other
executive officer (shikkou-yaku) or other officer or employee of the Company as may be designated in writing by the Board. 

“Securities Act” means the United States Securities Act of 1933, as amended. 

“Security” or “Securities” has the meaning stated in the first recital of this Indenture, or, as the case
may be, Securities that have been authenticated and delivered under this Indenture. 
 “Special Taxation Measures Act” has
the meaning set forth in Section 3.05(a). 
 “Specially-Related Person of the Company” has the meaning set forth in
Section 3.05(a). 
 “Specified Corporate Trust Office” means c/o Citibank N.A., Dublin Branch, One North Wall Quay,
Dublin 1, Ireland, Attention: Agency and Trust, Facsimile +353 1622 2210. 
 “Tax Documentation” has the meaning set forth
in Section 2.12(a). 
 “Trust Indenture Act” (except as otherwise provided in Article 7) means the United States
Trust Indenture Act of 1939 as in force at the date as of which this Indenture was originally executed. 
 “Trustee” means
the Person identified as “Trustee” in the first paragraph hereof and, subject to the provisions of Article 5, shall also include any successor trustee. 

“Trustee Parties” has the meaning set forth in Section 5.02(q). 

“USA Patriot Act” has the meaning set forth in Section 10.13. 

“Written Application for Tax Exemption” has the meaning set forth in Section 3.05. 

“Yen” means the coin or currency of Japan that at the time of payment is legal tender for the payment of public and private
debts. 
 “Yield to Maturity” means the yield to maturity on a series of securities, calculated at the time of issuance of
such series, or, if applicable, at the most recent redetermination of interest on such series, and calculated in accordance with accepted financial practice. 

ARTICLE 2 
 SECURITIES 

Section 2.01. Forms Generally. The Securities of each series shall be substantially in
such form (not inconsistent with this Indenture) as shall be established by or pursuant to a Board Resolution and set forth in an Officer’s Certificate or in one or more indentures supplemental hereto, in each case with such appropriate
insertions, omissions, substitutions and other variations as are required or permitted by this Indenture and may have imprinted or otherwise reproduced thereon such legend or legends, not inconsistent with the provisions of this Indenture, as may be
required to comply with any law or with any rules or regulations pursuant thereto, or with any rules of any securities exchange or to conform to general usage, all as may be determined by the officer or officers executing such Securities, as
evidenced by their execution of the Securities. 

  
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 The definitive Securities shall be printed or lithographed on security printed paper or may
be produced in any other manner, all as determined by the officer or officers executing such Securities, as evidenced by his or their execution of such Securities. 

Section 2.02. Form of Trustee’s Certification of Authentication.
Subject to the provisions of Section 5.13, the Trustee’s certificate of authentication on all Securities shall be in substantially the following form: 

Certificate of Authentication: 

This is one of the Securities of the series designated herein and referred to in the within-mentioned Indenture. 

 

									
	Date:	 	  
	 		 	
		 		 		 	Citibank, N.A.
		 		 		 	as Trustee
					
	     
	 	                                     
                           	 		 	 By:
	 	  

		 		 		 		 	 Name:

		 		 		 		 	 Title:

Section 2.03. Amount Unlimited; Issuable in Series. The aggregate principal amount of
Securities which may be authenticated and delivered under this Indenture is unlimited. 
 The Securities may be issued in one or more
series, and unless provided for otherwise in the form of Security or in an indenture supplemental hereto, each such series shall be direct, unconditional, unsubordinated and unsecured obligations of the Company and rank pari passu and without
preference among themselves and with all other unsecured obligations, other than subordinated obligations, of the Company (except for statutorily preferred exceptions) from time to time outstanding. There shall be established in or pursuant to a
Board Resolution (which Board Resolution may provide general authorization for such action and may provide that the specific terms of such action may be determined by officers of the Company authorized thereby) and set forth in an Officer’s
Certificate, or established in one or more indentures supplemental hereto, prior to the issuance of Securities of any series, 

(a)        the issue date of the Securities; 

(b)        the title and type of the Securities of the series (which shall distinguish the Securities
of the series from all other Securities); 
 (c)        the ranking of the Securities; 

(d)        the initial aggregate principal amount of the Securities and any limits upon the total
aggregate principal amount of the Securities of the series that may be authenticated and delivered under this Indenture (except for Securities authenticated and delivered upon registration of transfer of, or in exchange for, or in lieu of, other
Securities of the series pursuant to Section 2.08, Section 2.09, Section 2.11, Section 4.03 or Section 11.04); 

(e)        the issue price at which the Securities are to be originally issued, expressed as a
percentage of the principal amount; 
 (f)        the denominations in which Securities of the
series shall be issuable; 
 (g)        if other than Dollars, the coin or currency in which the
Securities of that series are denominated; 

  
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 (h)        the date or dates on which the principal
and premium, if any, of the Securities of the series is payable; 
 (i)        the rate or rates at
which the Securities of the series shall bear interest, if any, or the method by which such rate shall be determined, the date or dates from which such interest shall accrue, the interest payment dates on which such interest shall be payable and the
record dates (in the case of Registered Securities) for the determination of Holders to whom interest is payable and/or the method by which such rate or rates or date or dates shall be determined; 

(j)        if the amount of payments of principal or any premium or interest on the Securities of the
series may be determined with reference to an index based on a coin or currency other than that in which the Securities of the series are denominated, or with reference to any currencies, securities or baskets of securities, commodities or indices,
the manner in which such amounts shall be determined, to the extent permitted under applicable regulatory capital or other requirements of the FSA, or other applicable regulatory authority; 

(k)        the manner in which and the place or places where the principal of and any interest on the
Securities of the series shall be payable (subject to the provisions of Section 3.02); 

(l)        the right or requirement, if any, to extend the interest payment periods or defer or
cancel the payment of interest and the duration and effect of that extension, deferral or cancellation; 

(m)        any other events of default, modifications or elimination of any acceleration rights, or
covenants with respect to the Securities of such series and any terms required by or advisable under applicable laws or regulations or rating agency criteria, including laws and regulations relating to attributes required for the Securities to
qualify as capital or certain liabilities for regulatory, rating or other purposes; 

(n)        any conversion or exchange features of the Securities; 

(o)        whether and under what circumstances the Company will pay Additional Amounts on the
Securities for any tax, assessment or governmental charge withheld or deducted and, if so, whether it will have the option to redeem those Securities rather than pay the Additional Amounts, to the extent permitted under applicable regulatory capital
or other requirements of the FSA, or other applicable regulatory authority; 
 (p)        the
period or periods within which, the price or prices at which, and the terms and conditions upon which Securities of the series may be redeemed, in whole or in part, at the option of the Company, to the extent permitted under applicable regulatory
capital or other requirements of the FSA, or other applicable regulatory authority; 

(q)        whether and under what circumstances the Holders of the Securities may demand repayment of
the Securities prior to the stated maturity date and the terms and conditions thereof, to the extent permitted under applicable regulatory capital or other requirements of the FSA, or other applicable regulatory authority; 

(r)        if other than the principal amount thereof, the portion of the principal amount of
Securities of the series which shall be payable upon declaration of acceleration of the maturity thereof pursuant to Section 4.01 or provable in bankruptcy, civil rehabilitation, reorganization, insolvency or similar proceedings pursuant to
Section 4.02; 
 (s)        if other than the coin or currency in which the Securities of that
series are denominated, the coin or currency in which payment of the principal of, interest or premium, if any, on the Securities of such series shall be payable; 

  
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 (t)        if the principal of or interest on the
Securities of such series are to be payable, at the election of the Company or a Holder thereof, in a coin or currency other than that in which the Securities are denominated, the period or periods within which, and the terms and conditions upon
which, such election may be made; 
 (u)        whether the Securities of the series will be
issuable as Registered Securities (and if so, whether such Securities will be issuable as Registered Global Securities) and any restrictions applicable to the offer, sale, transfer, exchange or delivery of Registered Securities or the payment of
interest thereon; 
 (v)        if more than one Trustee, any trustees, and, if not the Trustee,
any authenticating or paying agents, transfer agents or registrars or any other agents, or any Clearing Organization with respect to the Securities of such series; 

(w)        any restrictions applicable to the offer, sale or delivery of the Securities; 

(x)        any provisions for the discharge of the Company’s obligations relating to the
Securities; 
 (y)        material U.S. federal or Japanese tax considerations; 

(z)        if the Securities of such series are to be issuable in definitive form (whether upon
original issue or upon exchange of a temporary Security of such series) only upon receipt of certain certificates or other documents or satisfaction of other conditions, the form and terms of such certificates, documents or conditions; 

(aa)        if the Securities are to be issued in other than book-entry form; 

(bb)        any listing of the Securities on a securities exchange; 

(cc)        whether a series of Securities may be reopened in a manner consistent with the terms of
this Indenture, without the consent of the Holders of the Securities of such series, for increases in the aggregate principal amount of such series or for the establishment of additional terms with respect to the Securities of such series; 

(dd)        whether the Securities of a series shall be excluded from participation with the
Securities of other series or otherwise differentiated from the Securities of other series in relation to any matter in respect of which the Securities generally or Securities of more than one series are contemplated by this Indenture to act
together or otherwise be treated or affected collectively; 
 (ee)        any write-down, write-up, bail-in or other provisions applicable to a particular series of Securities required by, relating to or in connection with applicable regulatory capital or other
requirements of the FSA or other applicable regulatory authority; and 
 (ff)        any other
terms of the series (which terms shall not be inconsistent with the provisions of this Indenture). 
 All Securities of any one series
shall be identical except as to denomination, issue date, issue price and, if applicable, the date from which interest shall accrue and the date on which interest shall be first paid, except as may otherwise be provided in or pursuant to a Board
Resolution and set forth in an Officer’s Certificate or in an indenture supplemental hereto, as referenced above. Securities of any one series need not be issued at the same time, and unless otherwise provided, a series may be reopened for
issuance of additional Securities of such series without the consent of any Holder; provided that such additional Securities must be fungible with the other Securities of the same series for U.S. federal income tax purposes. 

  
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 Section 2.04. Authentication and Delivery of
Securities. At any time and from time to time after the execution and delivery of this Indenture, the Company may deliver Securities of any series executed by the Company to the Trustee for authentication, and the Trustee shall thereupon
authenticate and deliver such Securities upon the written order of the Company, signed by any one Responsible Officer of the Company authorized by the Board to execute any such order, without any further action by the Company. In authenticating such
Securities and accepting the additional responsibilities under this Indenture in relation to such Securities, the Trustee shall be entitled to receive, and (subject to Section 5.01) shall be fully protected in relying upon: 

(a)        a copy of any Board Resolution relating to such series certified by a Responsible Officer
of the Company; 
 (b)        an executed supplemental indenture, if any; 

(c)        an Officer’s Certificate setting forth the form and terms of the Securities as
required pursuant to Section 2.01 and Section 2.03 and prepared in accordance with Section 10.05; 

(d)        an Opinion of Counsel, prepared in accordance with Section 10.05, to the effect that

 (i)        the form or forms and terms of such Securities have been established
by or pursuant to a Board Resolution or by a supplemental indenture as permitted by Section 2.01 and Section 2.03 in conformity with the provisions of this Indenture; 

(ii)        such Securities, when authenticated and delivered by the Trustee and
issued by the Company in the manner and subject to any conditions specified in such Opinion of Counsel, will constitute valid and binding obligations of the Company enforceable against the Company in accordance with their terms; 

(iii)        all laws and requirements in respect of the execution and delivery by
the Company of the Securities have been complied with; and 
 (iv)        covers
such other matters as the Trustee may reasonably request, including execution, delivery and validity of the Indenture and the Securities. 

The Trustee shall have the right to decline to authenticate and deliver any Securities under this Section if the Trustee, being advised by
counsel, determines that such action may not lawfully be taken by the Company, or if the Trustee in good faith shall determine that such action would expose the Trustee to personal liability to existing Holders. 

Section 2.05. Execution of Securities. The Securities shall be signed on behalf of the
Company by one (or, if so specified in the indenture supplemental hereto or Board Resolution establishing the terms thereof, more than one) Responsible Officer of the Company, which Securities may, but need not, be attested. Such signatures may be
the manual or facsimile signatures of the present or any future such officers. Typographical and other minor errors or defects in any such reproduction of any such signature shall not affect the validity or enforceability of any Security that has
been duly authenticated and delivered by the Trustee. 
 In case any officer of the Company who shall have signed any of the Securities
shall cease to be such officer before the Security so signed shall be authenticated and delivered by the Trustee or disposed of by the Company, such Security nevertheless may be authenticated and delivered or disposed of as though the person who
signed such Security had not ceased to be such officer of the Company; and any Security may be signed on behalf of the Company by such persons as, at the actual date of the execution of such Security, shall be the proper officers of the Company,
although at the date of the execution and delivery of this Indenture any such person was not such an officer. 

  
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 Section 2.06. Certificate of
Authentication. Only such Securities as shall bear thereon a certificate of authentication substantially in the form hereinbefore recited, executed by the Trustee by the manual signature of one of its authorized officers, shall be
entitled to the benefits of this Indenture or be valid or obligatory for any purpose. Such certificate by the Trustee upon any Security executed by the Company shall be conclusive evidence that the Security so authenticated has been duly
authenticated and delivered hereunder and that the holder is entitled to the benefits of this Indenture. 

Section 2.07. Form, Denomination and Date of Securities; Payments of Interest. 

(a)        The Securities shall be issued as Registered Global Securities and in denominations as
shall be specified as contemplated by Section 2.03. The Securities of any series shall be denominated in minimum principal amounts of $200,000 and in integral multiples of $1,000 in excess thereof, or such other denominations, integral
multiples and currencies as the Company may designate in a form of Security or an indenture supplemental hereto or Board Resolution establishing the terms thereof, in an aggregate principal amount that shall equal the aggregate principal amount of
the Securities that are to be issued. The Securities shall be issuable as Registered Securities without coupons. The Securities shall be numbered, lettered, or otherwise distinguished in such manner or in accordance with such plans as the
Responsible Officer of the Company executing the same may determine, as evidenced by such Responsible Officer’s execution of such Securities. 

Any of the Securities may be issued with appropriate insertions, omissions, substitutions and variations, and may have imprinted or otherwise
reproduced thereon such legend or legends, not inconsistent with the provisions of this Indenture, as may be required to comply with any law or with any rules or regulations pursuant thereto, or with the rules of the Depositary or any securities
market in which the Securities are admitted to trading, or to conform to general usage, or as the Company may determine appropriate to provide notice of any provision of Japanese law or regulation relating to taxation. 

Each Registered Global Security shall be delivered by the Trustee to and deposited with the Depositary or, pursuant to the Depositary’s
instructions, shall be delivered by the Trustee on behalf of the Depositary to and deposited with the Depositary’s custodian, and in either case shall be registered in such name as the Depositary shall specify. Registered Global Securities may
be deposited with such other Depositary that is a clearing agency registered under the Exchange Act as the Company may from time to time designate in writing to the Trustee, and shall bear such legend as may be appropriate. 

(b)        Each Security shall be dated the date of its authentication and shall bear interest from
the date, and shall be payable on the dates, specified on the reverse of the applicable form of Security, which shall be specified as contemplated by Section 2.03. 

(c)        The Person in whose name any Registered Security of any series is registered on any record
date with respect to any interest payment date shall be entitled to receive the interest payable on such interest payment date notwithstanding any transfer or exchange of such Security subsequent to such record date and prior to such interest
payment date, except if and to the extent the Company shall default in the payment of the interest due on such interest payment date for such series, in which case such defaulted interest shall be paid to the Persons in whose names Outstanding
Securities are registered on a subsequent record date (which shall be not less than five Business Days prior to the date of payment of such defaulted interest) established by notice given by mail by or on behalf of the Company to the holders of
Securities not less than 15 days preceding such subsequent record date. The term “record date” as used with respect to any interest payment date (except a date for payment of defaulted interest) shall have the meaning set forth in
the applicable form of reverse of the Securities of any particular series, or, if no such date is so specified, shall be the day five Business Days immediately preceding the applicable interest payment date. 

Section 2.08. Registration, Transfer and Exchange of Securities. 

(a)        An agent appointed by the Company, acting as the Company’s agent for such purposes
(the “Registrar”), will keep books for the registration, transfer and exchange of the Securities at the Specified 

  
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Corporate Trust Office of the Registrar. The Registrar shall also act as the transfer agent with respect to the transfer or exchange of the Securities or a beneficial interest in the Securities.
The Registrar will keep a record of all Securities (the “Register”) at said office. The Register will show the amount of the Securities, the date of issue, all subsequent transfers and changes of ownership in respect thereof and the
names, tax identifying numbers (if relevant to a specific holder), addresses of the registered holders of the Securities and any payment instructions with respect thereto (if different from a holder’s registered address). The Registrar will
also maintain a record which will include notations as to whether the Securities have been paid or cancelled, and, in the case of mutilated, destroyed, stolen or lost Securities, whether such Securities have been replaced. In the case of the
replacement of any of the Securities, such records will include notations of each Security so replaced, and the Security issued in replacement thereof. In the case of the cancellation of any of the Securities, such records will include notations of
each Security so cancelled and the date on which such Security was cancelled. The Registrar shall upon prior written request make the Register and such records available during normal office hours to the Company, or any Person authorized by the
Company in writing, for inspection and for the taking of copies thereof or extracts therefrom, and, at the expense of the Company, the Registrar shall deliver to such Persons all lists of Securityholders, their addresses and amounts of such holdings
as they may request. In acting hereunder and in connection with the Securities, the Registrar shall act solely as an agent of the Company. 

The respective principal amounts of each Registered Global Security may be increased or decreased by endorsement on the Register by the
Registrar of appropriate notations evidencing the dates and amounts of such increases and decreases in connection with transactions contemplated or permitted hereby. 

The Register and the records referred to above shall be in written form in the English language or in any other form capable of being
converted into such form within a reasonable time. 
 (b)        Upon due presentation for
registration of transfer of any Registered Security of any series at any such office or agency to be maintained for the purpose as provided in Section 3.02, the Company shall execute and the Trustee shall authenticate Securities and deliver in
the name or names of the transferee or transferees a new Security or Securities of the same series in authorized denominations for a like aggregate principal amount. 

Any Security or Securities of any series may be exchanged for a Security or Securities of the same series in other authorized denominations,
in an equal aggregate principal amount. Securities of any series to be exchanged shall be surrendered at any office or agency to be maintained by the Company for the purpose as provided in Section 3.02, and the Company shall execute and the
Trustee shall authenticate and deliver in exchange therefor the Security or Securities of the same series which the Holder making the exchange shall be entitled to receive, bearing numbers not contemporaneously outstanding. 

All Securities presented for registration of transfer, exchange, redemption or payment shall be duly endorsed by, or be accompanied by a
written instrument or instruments of transfer in form satisfactory to the Company and the Trustee duly executed by, the Holder or his attorney duly authorized in writing. 

The Company shall not be required to exchange or register a transfer of (a) any Securities of any series for a period of 15 days next
preceding the first mailing of a notice of redemption of Securities of such series to be redeemed, or (b) any Securities selected, called or being called for redemption except, in the case of any Security where public notice has been given that
such Security is to be redeemed in part, the portion thereof not so to be redeemed. 
 All Securities issued upon any transfer or exchange
of Securities shall be valid obligations of the Company, evidencing the same debt, and entitled to the same benefits under this Indenture, as the Securities surrendered upon such transfer or exchange. 

(c)        Transfer, registration and exchange shall be permitted as provided in this
Section 2.08 without any charge to the Securityholder except for the expenses of delivery (if any) not made by regular mail 

  
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(such delivery to be at the sole risk and expense of the transferee or holder, as applicable) and except, if the Company or the Registrar shall so require, the payment of a sum sufficient to
cover any stamp duty, tax or governmental charge or insurance charge that may be imposed in relation thereto. Registration of the transfer of a Security by the Registrar shall be deemed to be the sole acknowledgment of such transfer on behalf of the
Company. 
 (d)        The Trustee shall have no responsibility or obligation to any beneficial
owner of a Registered Global Security, a member of, or a participant in the Depositary or any other Person with respect to the accuracy of the records of the Depositary or its nominee or of any participant or member thereof, with respect to any
ownership interest in the Securities or with respect to the delivery to any participant, member, beneficial owner or other Person (other than the Depositary) of any notice (including any notice of redemption or repurchase) or the payment of any
amount, under or with respect to such Securities, and the Trustee may rely and shall be fully protected in relying upon information furnished by the Depositary with respect to its members, participants and any beneficial owners. The rights of
beneficial owners in any Registered Global Security shall be exercised only through the Depositary subject to the applicable rules and procedures of the Depositary. 

(e)        The Trustee shall have no obligation or duty to monitor, determine or inquire as to
compliance with any restrictions on transfer imposed under this Indenture or under applicable law with respect to any transfer of any interest in any Security other than to require delivery of such certificates and other documentation or evidence as
are expressly required by, and to do so if and when expressly required by the terms of, this Indenture, and to examine the same to determine substantial compliance as to form with the express requirements hereof. 

Section 2.09. Mutilated, Defaced, Destroyed, Lost and Stolen Securities. In case any
temporary or definitive Security shall become mutilated, defaced or be destroyed, lost or stolen, the Company in its discretion may execute, and upon the written request of any officer of the Company, the Trustee shall authenticate and deliver a new
Security of the same series, bearing a number not contemporaneously outstanding, in exchange and substitution for the mutilated or defaced Security, or in lieu of and substitution for the Security so destroyed, lost or stolen. In every case the
applicant for a substitute Security shall furnish to the Company and to the Trustee and any agent of the Company or the Trustee such security, indemnity and/or pre-funding as may be required by them to
indemnify and defend and to save each of them harmless and, in every case of destruction, loss or theft, evidence to their satisfaction of the destruction, loss or theft of such Security and of the ownership thereof and in the case of mutilation or
defacement the applicant shall surrender the Security to the Trustee or such agent. 
 Upon the issuance of any substitute Security, the
Company may require the payment of a sum sufficient to cover any tax or other governmental charge that may be imposed in relation thereto and any other expenses (including the fees and expenses of the Trustee or its agent) connected therewith. In
case any Security which has matured or is about to mature or has been called for redemption in full shall become mutilated or defaced or be destroyed, lost or stolen, the Company may instead of issuing a substitute Security, pay or authorize the
payment of the same (without surrender thereof except in the case of a mutilated or defaced Security), if the applicant for such payment shall furnish to the Company and the Trustee and any agent of the Company or the Trustee such security,
indemnity and/or pre-funding as any of them may require to save each of them harmless, and, in every case of destruction, loss or theft, the applicant shall also furnish to the Company and the Trustee and any
agent of the Company or the Trustee evidence to their satisfaction of the destruction, loss or theft of such Security and of the ownership thereof. 

Every substitute Security of any series issued pursuant to the provisions of this Section by virtue of the fact that any such Security is
destroyed, lost or stolen shall constitute an additional contractual obligation of the Company, whether or not the destroyed, lost or stolen Security shall be at any time enforceable by anyone and shall be entitled to all the benefits of (but shall
be subject to all the limitations of rights set forth in) this Indenture equally and proportionately with any and all other Securities of such series duly authenticated 

  
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and delivered hereunder. All Securities shall be held and owned upon the express condition that, to the extent permitted by law, the foregoing provisions are exclusive with respect to the
replacement or payment of mutilated, defaced or destroyed, lost or stolen Securities and shall preclude any and all other rights or remedies notwithstanding any law or statute existing or hereafter enacted to the contrary with respect to the
replacement or payment of negotiable instruments or other securities without their surrender. 

Section 2.10. Cancellation of Securities. All Securities surrendered for payment,
redemption, registration of transfer or exchange, if surrendered to the Company, or any agent of the Company or the Paying Agent, shall be delivered to the Trustee for cancellation or, if surrendered to the Trustee, shall be cancelled by it; and no
Securities shall be issued in lieu thereof except as expressly permitted by any of the provisions of this Indenture. The Trustee shall dispose of canceled Securities held by it in accordance with its procedures for the disposition of cancelled
securities in effect as of the date of such disposition and, upon receipt of a written request from the Company, deliver a certificate of disposition to the Company. If the Company shall acquire any of the Securities, such acquisition shall not
operate as a redemption or satisfaction of the indebtedness represented by such Securities unless and until the same are delivered to the Trustee for cancellation. 

Section 2.11. Temporary Securities. Pending the preparation of definitive Securities
for any series, the Company may execute and the Trustee shall authenticate and deliver temporary Securities for such series (printed, lithographed, typewritten or otherwise reproduced, in each case in form satisfactory to the Trustee). Temporary
Securities of any series shall be issuable as Registered Securities without coupons, of any authorized denomination, and substantially in the form of the definitive Securities of such series but with such omissions, insertions and variations as may
be appropriate for temporary Securities, all as may be determined by the Company with the reasonable concurrence of the Trustee. Temporary Securities may contain such reference to any provisions of this Indenture as may be appropriate. Every
temporary Security shall be executed by the Company and be authenticated by the Trustee upon the same conditions and in substantially the same manner, and with like effect, as the definitive Securities. Without unreasonable delay the Company shall
execute definitive Securities of such series and thereupon temporary Securities of such series may be surrendered in exchange therefor without charge at each office or agency to be maintained by the Company for that purpose pursuant to
Section 3.02, and the Trustee shall authenticate and deliver in exchange for such temporary Securities of such series a like aggregate principal amount of definitive Securities of the same series of authorized denominations. Until so exchanged,
the temporary Securities of any series shall be entitled to the same benefits under this Indenture as definitive Securities of such series unless otherwise established pursuant to Section 2.03. 

Section 2.12. Japanese Withholding Tax. 

(a)        In compliance with Japanese tax laws and the practices of tax authorities in Japan, in
respect of any interest payment on a series of Securities issued in global or book-entry form pursuant to this Indenture or any supplemental indenture hereto, any Paying Agent shall act in accordance with the Operating Manual — Japanese
Withholding Tax on Certain International Issues Held Through DTC (as may be amended from time to time by notice from the International Capital Market Association, the “DTC Procedures”), if DTC is acting as Clearing Organization with
respect to such series or with respect to depositary interests representing the Securities of such series, or in accordance with such other similar procedures as may be established by another Clearing Organization. Except as otherwise provided in
this Indenture, any such Paying Agent shall be responsible only for performing such services as are specifically provided for in the DTC Procedures or such other procedures actually known by the Paying Agent, as applicable and as may be amended or
modified and communicated to the Paying Agent from time to time. Any such Paying Agent and the Company may rely on the information provided in the Written Application for Tax Exemption (as defined below) and other documentation in the absence of
actual knowledge to the contrary. If any interest payment on a series of Securities is due to be made hereunder and if and so long as payments of interest (if any) by the Company to any Paying Agent may be made without deduction or withholding for
or on account of Japanese tax only upon receipt of certifications, the Written Application for Tax Exemption, notifications or other documentation in compliance with Japanese tax law requirements (“Tax Documentation”), the relevant
Paying Agent at the direction of the Company shall 

  
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(i) collect the required Tax Documentation from the Clearing Organization (or Holders of the Securities, if definitive Securities representing such series of Securities have been issued);
(ii) provide any required confirmations of information available to it; and (iii) promptly deliver such Tax Documentation so received to the Company for filing with the relevant Japanese district tax office. Any such Paying Agent may rely on
the information provided in Tax Documentation (including where relevant, supporting documentation) in the absence of actual knowledge that such information is incorrect. Neither the Company nor the Paying Agent shall have any liability for any
withholding of tax arising as a result of a late delivery of the required Tax Documentation or incorrectly completed Tax Documentation. 

(b)        If a Holder of the Securities or the holder of a beneficial interest in the Securities
satisfies the requirements for claiming an exemption from Japanese withholding tax after the date on which an amount in respect of such tax is withheld and before the date on which the tax is actually paid to the Japanese tax authorities, then the
Company or the Paying Agent acting at the direction of the Company shall, to the extent reasonably practicable and to the extent not prohibited by Japanese tax law, repay the amount withheld (after deduction of reasonable costs, including amounts in
respect of changes in foreign exchange rates) to the Holder. 
 (c)        The Paying Agent shall
furnish forms of certifications to Holders upon request, and shall use reasonable efforts to assist Holders in claiming available exemptions, but shall not be liable for a Holder’s failure to qualify for such an exemption. Based on the Tax
Documentation received, the Paying Agent will make the appropriate calculations of interest payable after making the relevant deductions in accordance with this Section 2.12. The Paying Agent will remit all amounts of tax withheld under this
Section 2.12 to or to the written order of the Company as soon as reasonably practicable in order to enable the Company to make the necessary payments to the relevant tax office in accordance with applicable laws and regulations. The Paying
Agent shall retain copies of Tax Documentation for a period of five years from the date as prescribed by Japanese tax laws and shall make such documentation available for inspection by the Company and any relevant tax authorities in Japan upon
written request given in reasonable notice from the Company. 
 Section 2.13. CUSIP, ISIN
Numbers and Common Codes. The Company in issuing the Securities may use CUSIP, ISIN numbers and Common Codes if then generally in use, and, if so, the Trustee shall use CUSIP, ISIN numbers and Common Codes in notices of redemption as a
convenience to Holders; provided, that any such notice may state that no representation is made as to the correctness of such numbers either as printed on the Securities or as contained in any notice of a redemption and that reliance may be
placed only on the other identification numbers printed on the Securities, and any such redemption shall not be affected by any defect in or omission of such numbers. The Company will promptly notify the Trustee in writing of any change in the
CUSIP, ISIN numbers or Common Codes. 
 ARTICLE 3 

COVENANTS OF THE COMPANY 
 
Section 3.01. Payment of Principal and Interest. The Company covenants and agrees for the benefit of each series of Securities that it will duly and punctually pay or cause to be paid the principal of, and interest on,
each of the Securities of such series (together with any Additional Amounts payable pursuant to the terms of such Securities) at the place or places, at the respective times and in the manner provided in such Securities. Subject to any other
provisions that may be established pursuant to Section 2.03, the interest on Securities (together with any Additional Amounts payable pursuant to the terms of such Securities) shall be payable only to or upon the written order of the Holders
thereof and, at the option of the Company, may be paid by wire transfer. The Trustee and the Paying Agent shall not be responsible in any manner whatsoever to pay any administrative costs imposed by banks in connection with the making of any
payments by wire transfer. Neither the Trustee nor any Paying Agent shall have any obligation to advance its own funds, and all payments on the Securities shall be made from immediately available funds deposited by the Company with the Trustee or
the Paying Agent no later than 10:00 a.m. New York time on the relevant payment date, provided, however, to the extent any such funds are received by the Trustee or the Paying Agent after 10:00 a.m. New York time, on such payment date,
such funds will be deemed deposited within one (1) Business Day of receipt thereof. 

  
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 The interest, if any, due in respect of any temporary or definitive Security, together with
any Additional Amounts payable in respect thereof, as provided in the terms and conditions of such Security, shall be payable, subject to the conditions set forth in Section 3.05, only upon presentation of such Security to the Trustee thereof
for notation thereon of the payment of such interest. 
 Section 3.02. Offices for Payments,
etc. So long as any of the Securities remain Outstanding, the Company will maintain in each Place of Payment the following for each series: an office or agency (a) where the Securities may be presented or surrendered for payment,
(b) where Registered Securities may be presented or surrendered for registration of transfer and for exchange as provided in this Indenture and (c) where notices and demands to or upon the Company in respect of the Securities or of this
Indenture may be served. The Company will give to the Trustee written notice of the location of any such office or agency and of any change of location thereof. Unless otherwise specified in accordance with Section 2.03, the Company hereby
initially designates the Corporate Trust Office of the Paying Agent as the office to be maintained by it for each such purpose in relation to Registered Securities. In case the Company shall fail to so designate or maintain any such office or agency
or shall fail to give such notice of the location or of any change in the location thereof, presentations, surrenders and demands may be made and notices may be served at the Corporate Trust Office. 

The Company may from time to time designate one or more offices or agencies (in addition to or in lieu of the office or agency established
pursuant to the preceding paragraph) where the Securities of a series may be presented or surrendered for payment and where Registered Securities of that series may be presented or surrendered for registration of transfer or for exchange as provided
in this Indenture, and the Company may from time to time rescind any such designation, as the Company may deem desirable or expedient; provided, however, that no such designation or rescission shall in any manner relieve the Company of its
obligation to maintain the agencies provided for in this Section. The Company will give to the Trustee prompt written notice of any such designation or rescission thereof. 

Section 3.03. Appointment to Fill a Vacancy in Office of Trustee. The Company,
whenever necessary to avoid or fill a vacancy in the office of Trustee, will appoint, in the manner provided in Section 5.09, a Trustee, so that there shall at all times be a Trustee with respect to each series of Securities hereunder. 

Section 3.04. Paying Agents. Whenever the Company shall appoint a Paying Agent other
than the Trustee with respect to the Securities of any series, it will cause such Paying Agent to execute and deliver to the Trustee an instrument in which such agent shall agree with the Trustee, subject to the provisions of this Section, 

(a)        that it will hold all sums received by it as such agent for the payment of the principal
of or interest on the Securities of such series (whether such sums have been paid to it by the Company or by any other obligor on the Securities of such series) in trust for the benefit of the Holders of the Securities of such series or of the
Trustee, and that it will pay the principal of, and interest on, each series of Securities as provided in this Indenture, 

(b)        that (unless such Paying Agent is the same bank as the Trustee) it will give the Trustee
notice of any failure by the Company (or by any other obligor on the Securities of such series) to make any payment of the principal of or interest on the Securities of such series when the same shall be due and payable, and 

(c)        that (unless such Paying Agent is the same bank as the Trustee) it will pay any such sums
so held in trust by it to the Trustee upon the Trustee’s written request at any time during the continuance of the failure referred to in Section 3.04(b) above. 

The Company will, no later than 10:00 a.m. New York time on each due date of the principal of or interest on the Securities of such series,
deposit with the Paying Agent a sum sufficient to pay such 

  
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principal or interest so becoming due, and (unless such Paying Agent is the Trustee) the Company will promptly notify the Trustee of any failure to take such action, provided,
however, to the extent any such funds are received by the Paying Agent after 10:00 a.m. New York time, on such payment date, such funds will be deemed deposited within one (1) Business Day of receipt thereof. 

If the Company shall act as its own Paying Agent with respect to the Securities of any series, it will, on or before each due date of the
principal of or interest on the Securities of such series, set aside, segregate and hold in trust for the benefit of the Holders of the Securities of such series a sum sufficient to pay such principal or interest so becoming due. The Company will
promptly notify the Trustee of any failure to take such action. 
 Anything in this Section to the contrary notwithstanding, the Company
may at any time, for the purpose of obtaining a satisfaction and discharge with respect to one or more or all series of Securities hereunder, or for any other reason, pay or cause to be paid to the Trustee all sums held in trust for any such series
by the Company or any Paying Agent hereunder, as required by this Section, such sums to be held by the Trustee upon the trusts herein contained. Upon the occurrence of any event specified in Section 4.01(d) or (e), the Trustee or one of its
affiliates shall automatically become the Paying Agent. 
 Anything in this Section to the contrary notwithstanding, the agreement to hold
sums in trust as provided in this Section is subject to the provisions of Section 9.03 and Section 9.04. 
 In acting hereunder
and in connection with the Securities, the Paying Agent shall act solely as an agent of the Company. 

Section 3.05. Additional Amounts. All payments of principal (and
premium, if any) or interest in respect of the Securities will be made without withholding or deduction for or on account of any present or future taxes, duties, assessments or governmental charges of whatever nature imposed or levied by or on
behalf of Japan or any authority thereof or therein having power to tax (“Japanese Taxes”), unless such withholding or deduction of such Japanese Taxes is required by law. In that event, the Company shall pay to the Holders such
additional amounts (“Additional Amounts”) as will result in the receipt by or on behalf of the Holders or beneficial owners of such amounts as would have been received by them had no such withholding or deduction been required,
provided that, no Additional Amounts shall be payable with respect to any Security: 

(a)        to, or to a third party on behalf of, a Securityholder or beneficial owner of a Security
who is an individual non-resident of Japan or a non-Japanese corporation and is liable for such Japanese Taxes in respect of such Security by reason of its
(1) having some connection with Japan other than the mere holding of such Security, or (2) being a person having a special relationship with the Company as described in Article 6, paragraph 4 of the Act on Special Measures Concerning
Taxation of Japan (Act No. 26 of 1957, as amended) (the “Special Taxation Measures Act”) (a “Specially-Related Person of the Company”); or 

(b)        to, or to a third party on behalf of, a Securityholder or beneficial owner of a Security
(A) who would otherwise be exempt from any such withholding or deduction but who fails to comply with any applicable requirement to provide Interest Recipient Information (as defined below) or to submit a Written Application for Tax Exemption
(as defined below) to the Paying Agent to whom the relevant Security is presented (where presentation is required), or (B) whose Interest Recipient Information is not duly communicated through the Participant (as defined below) and the relevant
Clearing Organization to such Paying Agent; or 
 (c)        to, or to a third party on behalf of,
a Securityholder or beneficial owner of a Security who is for Japanese tax purposes treated as an individual resident of Japan or a Japanese corporation (except for (A) a Designated Financial Institution (as defined below) which complies with
the requirement to provide Interest Recipient Information or to submit a Written Application for Tax Exemption and (B) an individual 

  
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resident of Japan or a Japanese corporation who duly notifies (directly or through the Participant or otherwise) the relevant Paying Agent of its status as not being subject to Japanese Taxes to
be withheld or deducted by the Company, by reason of such individual resident of Japan or Japanese corporation receiving interest on the relevant Security through a payment handling agent in Japan appointed by it); or 

(d)        where such Security is presented for payment (where presentation is required) more than 30
days after the date on which such payment first becomes due or after the date on which the full amount payable is duly provided for, whichever occurs later, except to the extent that the Holder of the Security would have been entitled to such
Additional Amounts on presenting the same for payment on the last day of such 30-day period; or 

(e)        any combination of (a) through (d) above; 

nor shall Additional Amounts be paid with respect to any payment on a Security to or on behalf of a Securityholder who is a fiduciary or
partnership or other than the sole beneficial owner of such payment to the extent such payment would be required by the laws of Japan to be included in the income, for tax purposes, of a beneficiary or settlor with respect to such fiduciary or a
member of such partnership or a beneficial owner who, in each case, would not have been entitled to the Additional Amounts had such beneficiary, settlor, member or beneficial owner been the Securityholder. The obligation to pay Additional Amounts
with respect to any taxes, duties, assessments or governmental charges shall not apply to (A) any estate, inheritance, gift, sales, transfer, personal property or any similar tax, duty, assessment or governmental charge or (B) any tax,
duty, assessment or governmental charge which is payable otherwise than by deduction or withholding from payments of principal of (and premium, if any) or interest on the Security. References to principal (and premium, if any) and interest in
respect of the Security will be deemed to include any Additional Amounts due which may be payable in respect of the principal (or premium, if any) or interest. 

Where a Security is held through a participant of a Clearing Organization or a financial intermediary, in each case, as prescribed by the
Special Taxation Measures Act (each, a “Participant”), in order to receive payments free of withholding or deduction by the Company for, or on account of, Japanese Taxes, if the relevant beneficial owner is (1) an individual non-resident of Japan or a non-Japanese corporation (other than a Specially-Related Person of the Company) or (2) a Japanese financial institution or financial
instruments business operator falling under certain categories prescribed by the cabinet order under Article 6, paragraph 9 of the Special Taxation Measures Act (a “Designated Financial Institution”), such beneficial owner shall, at
the time of entrusting a Participant with the custody of the relevant Security, provide certain information prescribed by the Special Taxation Measures Act and the cabinet order and other regulations thereunder to enable the Participant to establish
that such beneficial owner is exempted from the requirement for Japanese Taxes to be withheld or deducted (the “Interest Recipient Information”) and advise the Participant if the beneficial owner ceases to be so exempted (including
where the beneficial owner who is an individual non-resident of Japan or a non-Japanese corporation becomes a Specially-Related Person of the Company). 

Where a Security is not held by a Participant, in order to receive payments free of withholding or deduction by the Company for, or on
account of, Japanese Taxes, if the relevant beneficial owner is (i) an individual non-resident of Japan or a non-Japanese corporation (other than a
Specially-Related Person of the Company) or (ii) a Designated Financial Institution, such beneficial owner shall, prior to each time at which it receives interest, submit to the relevant Paying Agent a written application for tax exemption
(hikazei tekiyo shinkokusho) (a “Written Application for Tax Exemption”) in a form obtainable from the Paying Agent stating, inter alia, the name and address of the beneficial owner, the title of the Security, the relevant
interest payment date, the amount of interest and the fact that the beneficial owner is qualified to submit the Written Application for Tax Exemption, together with documentary evidence regarding its identity and residence. 

No Additional Amounts will be payable for or on account of any deduction or withholding imposed pursuant to Sections 1471-1474 of the U.S.
Internal Revenue Code, the U.S. Treasury regulations 

  
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thereunder and any other official guidance thereunder (“FATCA”), any intergovernmental agreement entered into with respect to FATCA, or any law, regulation or other official
guidance enacted in any jurisdiction implementing, or relating to, FATCA, similar legislation under the laws of any other jurisdiction, or any such intergovernmental agreement. 

If there is any withholding or deduction for or on account of Japanese Taxes with respect to payments on the Securities, the Company will use
reasonable efforts to obtain certified copies of tax receipts evidencing the payment of such Japanese Taxes from the Japanese taxing authority imposing such Japanese Taxes, and if certified copies are not available, the Company will use reasonable
efforts to obtain other evidence of payment satisfactory to the Trustee. The Trustee shall make such certified copies or other evidence available to the Holders or the beneficial owners of the Securities upon reasonable request to the Trustee. 

The Company will pay all stamp, court or documentary taxes or any excise or property taxes, charges or similar levies and other duties, if
any, which may be imposed by Japan, the United States or any political subdivision or any taxing authority thereof or therein, with respect to this Indenture or any indenture supplemental hereto, or as a consequence of the initial issuance,
execution, delivery, registration or enforcement of the Securities. 

Section 3.06. Certificate of the Company. So long as any Securities are Outstanding
under this Indenture, the Company will furnish to the Trustee within 120 days of the end of the Company’s fiscal year each year (which fiscal year ends [            ] and beginning
with the year following the first issuance of any Securities pursuant to this Indenture) a brief certificate (which need not comply with Section 10.05) from the principal executive, financial or accounting officer of the Company, as to his or
her knowledge of the Company’s compliance with all conditions and covenants under this Indenture (such compliance to be determined without regard to any period of grace or requirement of notice provided under this Indenture) substantially in
the form set forth in Exhibit A. 
 Section 3.07. Securityholders Lists. If and so
long as the Trustee shall not be the Registrar for the Securities of any series, the Company will furnish or cause to be furnished to the Trustee a list in such form as the Trustee may reasonably require of the names and addresses of the Holders of
the Securities of such series pursuant to Section 312 of the Trust Indenture Act (a) not more than 15 days after each record date for the payment of interest on such Securities, as hereinabove specified, as of such record date and on dates
to be determined pursuant to Section 2.03 for non-interest bearing securities in each year, and (b) at such other times as the Trustee may reasonably request in writing, within 30 days after receipt
by the Company of any such request as of a date not more than 15 days prior to the time such information is furnished. 
 
Section 3.08. Statement by Officers as to Default. The Company shall deliver to the Trustee, reasonably promptly (but no later than thirty (30) days) after the Company becomes aware of the occurrence of any Event of Default or
an event which, with notice or the lapse of time or both, would constitute an Event of Default, an Officer’s Certificate setting forth the details of such Event of Default or default and the action which the Company proposes to take with
respect thereto. 
 Section 3.09. Reports by the Company. The Company covenants to file
with the Trustee, within 30 days after the Company files the same with the Commission, copies of any annual reports and of the information, documents and other reports that the Issuer may be required to file with the Commission pursuant to
Section 13 or Section 15(d) of the Exchange Act as long as any Securities are Outstanding hereunder. Delivery of such reports, information and documents to the Trustee is for informational purposes only and the Trustee’s receipt of
such reports shall not constitute actual or constructive notice or knowledge of any information contained therein or determinable from information contained therein, including the Company’s compliance with any of its covenants hereunder (as to
which the Trustee is entitled to rely exclusively on an Officer’s Certificate). 

  
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 Section 3.10. Notices to Holders. The
Company shall deliver to the Trustee an advance copy of any Company notice to Holders before it is delivered to Holders. Citibank, N.A.’s name may not be used in any such notice without the express permission of Citibank, N.A. 

ARTICLE 4 
 REMEDIES OF THE TRUSTEE
AND SECURITYHOLDERS ON EVENT OF DEFAULT 
 Section 4.01. Event of Default, Acceleration of
Maturity, Waiver of Default. Unless otherwise established in accordance with Section 2.03 or by any applicable supplemental indenture, “Event of Default,” with respect to Securities of any series wherever used
herein, means each one of the following events which shall have occurred and be continuing (whatever the reason for such Event of Default and whether it shall be voluntary or involuntary or be effected by operation of law or pursuant to any
judgment, decree or order of any court or any order, rule or regulation of any administrative or governmental body): 

(a)        default by the Company in the payment when due of principal or any premium in respect of
any of the Securities on the date when due and such non-payment continues for a period of seven days; 

(b)        default by the Company in the payment when due of the interest in respect of any of the
Securities and the continuance of any such default for a period of 30 days after the date when due, unless the Company shall have cured such default by payment within such period; or 

(c)        the Company shall fail duly to perform or observe any other term, covenant or agreement
contained in any of the Securities of such series or in this Indenture in respect of the Securities of such series for a period of 90 days after the date on which written notice of such failure, requiring the Company to remedy the same, shall have
been given first to the Company (and to the Trustee in the case of notice by the Holders referred to below) by the Trustee or Holders of at least 25% in principal amount of the then Outstanding Securities of such series (such notification must
specify the Event of Default, demand that it be remedied and state that the notification is a “Notice of Default” hereunder); or 

(d)        a decree or order by any court having jurisdiction shall have been issued adjudging the
Company bankrupt or insolvent or approving a petition seeking reorganization under the Bankruptcy Act of Japan (Act No. 75 of 2004, as amended) (the “Bankruptcy Act”), the Civil Rehabilitation Act of Japan (Act No. 225 of
1999, as amended) (the “Civil Rehabilitation Act”), the Corporate Reorganization Act of Japan (Act No. 154 of 2002, as amended) (the “Corporate Reorganization Act”), the Companies Act of Japan (Act
No. 86 of 2005, as amended) (the “Companies Act”) or any other similar applicable law of Japan, and such decree or order shall have continued undischarged or unstayed for a period of 60 days; or a decree or order of a court
having jurisdiction for the appointment of a receiver or liquidator or trustee or assignee in bankruptcy or insolvency of the Company or of all or substantially all of its property or for the winding-up or
liquidation of its affairs, shall have been issued, and such decree or order shall have continued undischarged or unstayed for a period of 60 days; or 

(e)        the Company shall institute proceedings seeking adjudication of bankruptcy or seeking
reorganization under the Bankruptcy Act, the Civil Rehabilitation Act, the Corporate Reorganization Act, the Companies Act or any other similar applicable law of Japan, or shall consent to the institution of any such proceedings or shall consent to
the appointment of a receiver or liquidator or trustee or assignee in bankruptcy or insolvency of itself or of all or substantially all of its property, or an effective resolution shall have been passed by the Company for the winding up or
dissolution of its affairs, other than for the purpose of an amalgamation or merger, provided that the continuing or successor corporation has effectively assumed the obligations of the Company under such series of Securities and this
Indenture; or 
 (f)        any other Event of Default provided in the supplemental indenture or
Board Resolution (as set forth in an Officer’s Certificate) under which such series of Securities is issued or in the form of Security for such series. 

  
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 Unless otherwise set forth in any applicable supplemental indenture, if an Event of Default
described above occurs and is continuing with respect to a series, then, and in each and every such case, unless the principal of all of the Securities of such series has already become due and payable, either the Trustee or the holders of not less
than 25% in aggregate principal amount of the Securities of such series then Outstanding hereunder by notice in writing to the Company (and to the Trustee if given by Securityholders), may declare the entire principal (or, if the Securities of any
such affected series are Original Issue Discount Securities, such portion of the principal amount as may be specified in the terms of such series) of all Securities of such series, and the interest accrued thereon, to be due and payable immediately,
and upon any such declaration the same shall become immediately due and payable. 
 The foregoing provisions, however, are subject to the
condition that if, at any time after the principal (or, if the Securities are Original Issue Discount Securities, such portion of the principal as may be specified in the terms thereof) of the Securities of any series shall have been so declared due
and payable, and before any judgment or decree for the payment of the moneys due shall have been obtained or entered as hereinafter provided, the Company shall pay or shall deposit with the Trustee a sum sufficient to pay all matured installments of
interest upon all the Securities of such series and the principal of any and all Securities of such series which shall have become due otherwise than by acceleration (with interest upon such principal and, to the extent that payment of such interest
is enforceable under applicable law, on overdue installments of interest, at the same rate as the rate of interest or Yield to Maturity (in the case of Original Issue Discount Securities) specified in the Securities of such series to the date of
such payment or deposit) and such amount as shall be sufficient to cover reasonable compensation to the Trustee, its agents, attorneys and counsel, and all other reasonable expenses and liabilities incurred, and all advances made, by the Trustee
except as a result of willful misconduct, negligence or bad faith, and if any and all Events of Default with respect to such series, other than the non-payment of the principal of Securities which shall have
become due by acceleration, shall have been cured, waived or otherwise remedied as provided herein — then and in every such case the holders of a majority in aggregate principal amount of all the Securities of such series then Outstanding, by
written notice to the Company and to the Trustee, may waive all defaults with respect to such series and rescind and annul such declaration and its consequences, but no such waiver or rescission and annulment shall extend to or shall affect any
subsequent default or shall impair any right consequent thereon. 
 For all purposes under this Indenture, if a portion of the principal of
any Original Issue Discount Securities shall have been accelerated and declared due and payable pursuant to the provisions hereof, then, from and after such declaration, unless such declaration has been rescinded and annulled, the principal amount
of such Original Issue Discount Securities shall be deemed, for all purposes hereunder, to be such portion of the principal thereof as shall be due and payable as a result of such acceleration, and payment of such portion of the principal thereof as
shall be due and payable as a result of such acceleration, together with interest, if any, thereon and all other amounts owing thereunder, shall constitute payment in full of such Original Issue Discount Securities. 

Section 4.02. Collection of Indebtedness by Trustee; Trustee May File Proof of Claim.
The Company covenants that (a) in case default shall be made in the payment of any installment of interest on any of the Securities of any series when such interest shall have become due and payable, and such default shall have continued
for a period of 30 days or (b) in case default shall be made in the payment of all or any part of the principal of any of the Securities of any series when the same shall have become due and payable, whether upon maturity of the Securities of
such series or upon any redemption or by declaration or otherwise, then upon demand of the Trustee, the Company will pay to the Trustee for the benefit of the Holders of the Securities of such series the whole amount that then shall have become due
and payable on all Securities of such series for principal or interest, as the case may be (with interest to the date of such payment upon the overdue principal and, to the extent that payment of such interest is enforceable under applicable law, on
overdue installments of interest, at the same rate as the rate of interest or Yield to Maturity (in the case of Original Issue Discount Securities) specified in the Securities of such series); and in addition thereto, such further amount as shall be
sufficient to cover the costs and expenses of collection, including reasonable compensation to the Trustee, its 

  
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agents, attorneys and counsel, and liabilities and reasonable expenses incurred, and all advances made, by the Trustee except as a result of its willful misconduct, negligence or bad faith. 

Until such demand is made by the Trustee, the Company may pay the principal of and interest on the Securities of any series to the Holders,
whether or not the principal of and interest on the Securities of such series be overdue. 
 In case the Company shall fail forthwith to
pay such amounts upon such demand, the Trustee, in its own name and as trustee of an express trust, shall be entitled and empowered to institute any action or proceedings at law or in equity for the collection of the sums so due and unpaid, and may
prosecute any such action or proceedings to judgment or final decree, and may enforce any such judgment or final decree against the Company or other obligor upon such Securities and collect in the manner provided by law out of the property of the
Company or other obligor upon such Securities, wherever situated, the moneys adjudged or decreed to be payable. 
 In case there shall be
pending judicial proceedings relative to the Company or any other obligor upon the Securities under any applicable bankruptcy, civil rehabilitation, reorganization, insolvency or other similar law, or in case a receiver, assignee or trustee in
bankruptcy, civil rehabilitation, reorganization or insolvency, or a liquidator, sequestrator or similar official shall have been appointed for or taken possession of the Company or its property or such other obligor, or in case of any other
comparable judicial proceedings relative to the Company or other obligor upon the Securities of any series, or to the creditors or property of the Company or such other obligor, the Trustee, irrespective of whether the principal of any Securities
shall then be due and payable as therein expressed or by declaration or otherwise and irrespective of whether the Trustee shall have made any demand pursuant to the provisions of this Section, shall be entitled and empowered, by intervention in such
judicial proceedings or otherwise: 
 (a)        to file and prove a claim or claims for the whole
amount of principal and interest (or, if the Securities of any series are Original Issue Discount Securities, such portion of the principal amount as may be specified in the terms of such series) owing and unpaid in respect of the Securities of any
series, and to file such other papers or documents as may be necessary or advisable in order to have the claims of the Trustee (including any claim for reasonable compensation to the Trustee, and its agents, attorneys and counsel, and for
reimbursement of all liabilities and reasonable expenses incurred, and all advances made, by the Trustee, except as a result of willful misconduct, negligence or bad faith) and of the Securityholders allowed in any judicial proceedings relative to
the Company or other obligor upon the Securities of any series, or to the creditors or property of the Company or such other obligor, 

(b)        unless prohibited by applicable law and regulations, to vote on behalf of the holders of
the Securities of any series in any election of a trustee or a standby trustee or receiver or standby receiver in arrangement, reorganization, liquidation or other bankruptcy, civil rehabilitation, reorganization or insolvency proceedings or person
performing similar functions in comparable proceedings, and 
 (c)        to collect and receive
any moneys or other property payable or deliverable on any such claims, and to distribute all amounts received with respect to the claims of the Securityholders and of the Trustee on their behalf; and any trustee, receiver, or liquidator, custodian
or other similar official is hereby authorized by each of the Securityholders to make payments to the Trustee, and, in the event that the Trustee shall consent to the making of payments directly to the Securityholders, to pay to the Trustee such
amounts as shall be sufficient to cover reasonable compensation to the Trustee, and its agents, attorneys and counsel, and liabilities and reasonable expenses incurred, and all advances made, by the Trustee except as a result of willful misconduct,
negligence or bad faith. 
 Nothing herein contained shall be deemed to authorize the Trustee to authorize or consent to or vote for or
accept or adopt on behalf of any Securityholder any plan of reorganization, arrangement, adjustment 

  
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or composition affecting the Securities of any series or the rights of any Holder thereof, or to authorize the Trustee to vote in respect of the claim of any Securityholder in any such
proceeding, except, as aforesaid, to vote for the election of a trustee in bankruptcy or similar person. 
 All rights of action and of
asserting claims under this Indenture, or under any of the Securities, may be enforced by the Trustee without the possession of any of the Securities or the production thereof in any trial or other proceedings relative thereto, and any such action
or proceedings instituted by the Trustee shall be brought in its own name as Trustee of an express trust, and any recovery of judgment, subject to the payment of the expenses, disbursements and compensation of the Trustee and its respective agents
and attorneys, shall be for the ratable benefit of the holders of the Securities in respect of which such action was taken. 
 In any
proceedings brought by the Trustee (and also any proceedings involving the interpretation of any provision of this Indenture to which the Trustee shall be a party) the Trustee shall be held to represent all the holders of the Securities in respect
to which such action was taken, and it shall not be necessary to make any holders of such Securities parties to any such proceedings. 
 
Section 4.03. Application of Proceeds. Any moneys collected by the Trustee pursuant to this Article in respect of any series shall be applied in the following order at the date or dates fixed by the Trustee and, in case
of the distribution of such moneys on account of principal or interest, upon presentation of the several Securities in respect of which monies have been collected and stamping (or otherwise noting) thereon the payment, or issuing Securities of such
series in reduced principal amounts in exchange for the presented Securities of like series if only partially paid, or upon surrender thereof if fully paid: 

FIRST: Except as otherwise expressly provided herein, to the payment of costs, fees and expenses (including indemnity payments) applicable to
such series in respect of which monies have been collected, including reasonable compensation (i) first, to the Trustee and its agents and attorneys and of all liabilities and reasonable expenses incurred, and all advances made, by the Trustee, and
(ii) next to the Registrar, any Paying Agent and their respective agents and attorneys and of all liabilities and reasonable expenses incurred, and all advances made, by the Registrar and any Paying Agent; 

SECOND: In case the principal of the Securities of such series in respect of which moneys have been collected shall not have become and be
then due and payable, to the payment of interest on the Securities of such series in default in the order of the maturity of the installments of such interest, with interest (to the extent that such interest has been collected by the Trustee) upon
the overdue installments of interest at the same rate as the rate of interest or Yield to Maturity (in the case of Original Issue Discount Securities) specified in such Securities, such payments to be made ratably to the persons entitled thereto,
without discrimination or preference; 
 THIRD: In case the principal of the Securities of such series in respect of which moneys have been
collected shall have become and shall be then due and payable, to the payment of the whole amount then owing and unpaid upon all the Securities of such series for principal and interest, with interest upon the overdue principal, and (to the extent
that such interest has been collected by the Trustee) upon overdue installments of interest at the same rate as the rate of interest or Yield to Maturity (in the case of Original Issue Discount Securities) specified in the Securities of such series;
and in case such moneys shall be insufficient to pay in full the whole amount so due and unpaid upon the Securities of such series, then to the payment of such principal and interest or Yield to Maturity, without preference or priority of principal
over interest or Yield to Maturity, or of interest or Yield to Maturity over principal, or of any installment of interest over any other installment of interest, or of any Security of such series over any other Security of such series, ratably to
the aggregate of such principal and accrued and unpaid interest or Yield to Maturity; and 
 FOURTH: To the payment of the remainder, if
any, to the Company or any other person lawfully entitled thereto. 

  
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 Section 4.04. Suits for Enforcement.
In case an Event of Default has occurred, has not been waived and is continuing, the Trustee may in its discretion proceed to protect and enforce the rights vested in it by this Indenture by such appropriate judicial proceedings as the Trustee
shall deem most effectual to protect and enforce any of such rights, either at law or in equity or in bankruptcy or otherwise, whether for the specific enforcement of any covenant or agreement contained in this Indenture or in aid of the exercise of
any power granted in this Indenture or to enforce any other legal or equitable right vested in the Trustee by this Indenture or by law. 
 
Section 4.05. Restoration of Rights on Abandonment of Proceeding. In case the Trustee or any Holder of a Security shall have proceeded to enforce any right under this Indenture and such proceedings shall have been
discontinued or abandoned for any reason, or shall have been determined adversely to the Trustee or such Securityholder, then and in every such case the Company and the Trustee or such Securityholder shall be restored respectively to their former
positions and rights hereunder, and all rights, remedies and powers of the Company, the Trustee and the Securityholders shall continue as though no such proceedings had been taken. 

Section 4.06. Limitations on Suits by Securityholders. No Holder of any Security of
any series shall have any right by virtue or by availing of any provision of this Indenture or the Securities to institute any action or proceeding at law or in equity or in bankruptcy or otherwise upon or under or with respect to this Indenture, or
for the appointment of a trustee, receiver, liquidator, custodian or other similar official or for any other remedy hereunder or under the Securities, except actions for payment of overdue principal and interest, unless such Holder previously shall
have given to the Trustee written notice of an Event of Default and of the continuance thereof, as hereinbefore provided, and unless also the Holders of not less than 25% in aggregate principal amount of the Securities of the affected series then
Outstanding (each such series treated as a single class) shall have made written request upon the Trustee to institute such action or proceedings in its own name as Trustee hereunder or under the Securities and shall have offered to the Trustee such
security, indemnity and/or pre-funding satisfactory to the Trustee as it may require against the costs, expenses and liabilities to be incurred therein or thereby, the Trustee for 60 days after its receipt of
such notice, request and offer of security, indemnity and/or pre-funding satisfactory to the Trustee shall have failed to institute any such action or proceeding, and no direction inconsistent with such
written request shall have been given to the Trustee during such 60-day period pursuant to Section 4.09; it being understood and intended, and being expressly covenanted by the taker and Holder of every
Security with every other taker and Holder and the Trustee, that no one or more Holders of Securities of any series shall have any right in any manner whatever by virtue or by availing of any provision of this Indenture or the Securities to affect,
disturb or prejudice the rights of any other such Holder of Securities, or to obtain or seek to obtain priority over or preference to any other such Holder or to enforce any right hereunder or under the Securities, except in the manner herein
provided and for the equal, ratable and common benefit of all Holders of Securities of the applicable series. For the protection and enforcement of the provisions of this Section, each and every Securityholder and the Trustee shall be entitled to
such relief as can be given either at law or in equity. 
 Section 4.07. Unconditional Right
of Securityholders to Institute Certain Suits. Notwithstanding any other provision in this Indenture and any provision of any Security, the right of any Holder of any Security to receive payment of the principal of and any premium and
interest on such Security (subject to Section 3.01 hereof) on or after the respective due dates expressed in such Security, or to institute suit for the enforcement of any such payment on or after such respective dates, shall not be impaired or
affected without the consent of such Holder. 
 Section 4.08. Powers and Remedies Cumulative;
Delay or Omission Not Waiver of Default. Except as provided in Section 4.06 and except as otherwise provided with respect to the replacement or payment of mutilated, destroyed, lost or stolen Securities in the last paragraph of
Section 2.09, no right or remedy herein conferred upon or reserved to the Trustee or to the Securityholders is intended to be exclusive of any other right or remedy, and every right and remedy shall, to the extent permitted by law, be
cumulative and in addition to every other right and remedy given hereunder or now or hereafter existing at law or in equity or otherwise. The 

  
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assertion or employment of any right or remedy hereunder, or otherwise, shall not prevent the concurrent assertion or employment of any other appropriate right or remedy. 

No delay or omission of the Trustee or of any Securityholder to exercise any right or power accruing upon any Event of Default occurring and
continuing as aforesaid shall impair any such right or power or shall be construed to be a waiver of any such Event of Default or an acquiescence therein; and, subject to Section 4.06, every power and remedy given by this Indenture or by law to
the Trustee or to the Securityholders may be exercised from time to time, and as often as shall be deemed expedient, by the Trustee or by the Securityholders. 

Section 4.09. Control by Securityholders. The Holders of a majority in aggregate
principal amount of the Securities of each series affected (with all such series voting as a single class) at the time Outstanding shall have the right to direct the time, method, and place of conducting any proceeding for any remedy available to
the Trustee, or exercising any trust or power conferred on the Trustee with respect to the Securities of such series by this Indenture; provided that (1) such direction shall not be in conflict with any rule of law or with this Indenture, (2)
the Trustee may refuse to follow any direction that may involve the Trustee in personal liability, (3) the Trustee may refuse to follow any direction that the Trustee determines in good faith may be unduly prejudicial to the rights of
Securityholders not joining in the giving of such direction (it being understood that the Trustee does not have an affirmative duty to ascertain whether or not any such directions are unduly prejudicial to such Securityholders), and (4) the
Trustee may take any other action deemed proper by the Trustee which is not inconsistent with such direction. 
 
Section 4.10. Waiver of Past Defaults. Prior to the acceleration of the maturity of any Securities as provided in Section 4.01, the Holders of a majority in aggregate principal amount of the Securities of all series
at the time Outstanding with respect to which an Event of Default shall have occurred and be continuing (voting as a single class) may on behalf of the Holders of all such Securities waive any past default or Event of Default described in
Section 4.01 and its consequences, except a default in respect of a covenant or provision hereof which cannot be modified or amended without the consent of the Holder of each Security affected. In the case of any such waiver, the Company, the
Trustee and the Holders of all such Securities shall be restored to their former positions and rights hereunder, respectively; but no such waiver shall extend to any subsequent or other default or impair any right consequent thereon. 

Upon any such waiver, such default shall cease to exist and be deemed to have been cured and not to have occurred, and any Event of Default
arising therefrom shall be deemed to have been cured, and not to have occurred for every purpose of this Indenture; but no such waiver shall extend to any subsequent or other default or Event of Default or impair any right consequent thereon. 

Section 4.11. Trustee to Give Notice of Default. The Trustee shall give to the
Securityholders of any series, as the names and addresses of such Holders appear on the Register, notice by mail (or by other means provided in a supplemental indenture hereto or the Board Resolution under which such series of Securities is issued
or in the form of Security for such series) of all defaults known to the Trustee which have occurred with respect to such series, such notice to be transmitted within 90 days after the occurrence thereof, unless such defaults shall have been cured
before the giving of such notice (the term “default” or “defaults” for the purposes of this Section being hereby defined to mean any event or condition which is, or with notice or lapse of time or both would become, an Event of
Default). 
 Section 4.12. Right of Court to Require Filing of Undertaking to Pay
Costs. All parties to this Indenture agree, and each Holder of any Security by his acceptance thereof shall be deemed to have agreed, that any court may in its discretion require, in any suit for the enforcement of any right or remedy
under this Indenture or in any suit against the Trustee for any action taken, suffered or omitted by it as Trustee, the filing by any party litigant in such suit of an undertaking to pay the costs of such suit, and that such court may in its
discretion assess reasonable costs, including reasonable attorneys’ fees, against any party litigant in such suit, 

  
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having due regard to the merits and good faith of the claims or defenses made by such party litigant; but the provisions of this Section shall not apply to any suit instituted by the Trustee, to
any suit instituted by any Securityholder or group of Securityholders of any series holding in the aggregate more than 10% in aggregate principal amount of the Securities of such series, or, in the case of any suit relating to or arising under
Section 4.01(c) (if the suit relates to Securities of more than one but less than all series), 10% in aggregate principal amount of Securities Outstanding affected thereby, or in the case of any suit relating to or arising under
Section 4.01(c) (if the suit relates to all the Securities then Outstanding), Section 4.01(d), 10% in aggregate principal amount of all Securities Outstanding, or to any suit instituted by any Securityholder for the enforcement of the
payment of the principal of or interest on any Security on or after the due date expressed in such Security. 
 
Section 4.13. Judgment Currency. The Company agrees, to the fullest extent that it may effectively do so under applicable law, that (a) if for the purpose of obtaining judgment in any court it is necessary to convert
the sum due in respect of the principal of or interest on the Securities of any series (the “Required Currency”) into a currency in which a judgment will be rendered (the “Judgment Currency”), the rate of exchange
used shall be the rate at which in accordance with normal banking procedures the Trustee could purchase in The City of New York the Required Currency with the Judgment Currency on the day following the date on which final unappealable judgment is
entered, unless such day is not a New York Banking Day, then, to the extent permitted by applicable law, the rate of exchange used shall be the rate at which in accordance with normal banking procedures the Trustee could purchase in The City of New
York the Required Currency with the Judgment Currency on the New York Banking Day preceding the day on which final unappealable judgment is entered and (b) its obligations under this Indenture to make payments in the Required Currency
(1) shall not be discharged or satisfied by any tender, or any recovery pursuant to any judgment (whether or not entered in accordance with subsection (a)), in any currency other than the Required Currency, except to the extent that such tender
or recovery shall result in the actual receipt, by the payee, of the full amount of the Required Currency expressed to be payable in respect of such payments, (2) shall be enforceable as an alternative or additional cause of action for the
purpose of recovering in the Required Currency the amount, if any, by which such actual receipt shall fall short of the full amount of the Required Currency so expressed to be payable and (3) shall not be affected by judgment being obtained for
any other sum due under this Indenture. If the Required Currency so purchased with the Judgment Currency are greater than the sum originally due in the Required Currency hereunder, the Trustee shall pay to the Company an amount equal to the excess
of the Required Currency so purchased over the sum originally due in the Required Currency hereunder in accordance with a written request from the Company stating the amount of the excess. For purposes of the foregoing, “New York Banking
Day” means any day except a Saturday, Sunday or a legal holiday in The City of New York or a day on which banking institutions in The City of New York are authorized or required by law or executive order to close. 

ARTICLE 5 
 CONCERNING THE TRUSTEE

 Section 5.01. Duties and Responsibilities of the Trustee; During Default; Prior to
Default. With respect to the Holders of any series of Securities issued hereunder, the Trustee, prior to the occurrence of an Event of Default with respect to the Securities of a particular series of which a Responsible Officer of the
Trustee has written notice or actual knowledge and after the curing or waiving of all Events of Default which may have occurred with respect to such series, undertakes to perform such duties and only such duties as are specifically set forth in this
Indenture. In case an Event of Default with respect to the Securities of a series has occurred (which has not been cured or waived) the Trustee shall exercise with respect to such series of Securities such of the rights and powers vested in it by
this Indenture, and use the same degree of care and skill in their exercise, as a prudent person would exercise or use under the circumstances in the conduct of his or her own affairs. 

  
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 No provision of this Indenture shall be construed to relieve the Trustee from liability for
its own negligent action, its own negligent failure to act or its own willful misconduct, except that 

(a)        prior to the occurrence of an Event of Default with respect to the Securities of any
series of which a Responsible Officer at the Trustee has written notice or actual knowledge and after the curing or waiving of all such Events of Default with respect to such series which may have occurred: 

(i)        the duties and obligations of the Trustee with respect to the Securities
of such series shall be determined solely by the express provisions of this Indenture, and the Trustee shall not be liable except for its negligence or willful misconduct in the performance of such duties and obligations as are specifically set
forth in this Indenture, and no implied covenants or obligations shall be read into this Indenture against the Trustee; and 

(ii)        in the absence of bad faith on the part of the Trustee, the Trustee may
conclusively without liability rely, and act or refrain from acting as to the truth of the statements and the correctness of the opinions expressed therein, upon any statements, certificates or opinions furnished to the Trustee and conforming with
the requirements of this Indenture; but in the case of any such statements, certificates or opinions which by any provision hereof are specifically required to be furnished to the Trustee, the Trustee shall examine the same to determine whether or
not they conform to the requirements of this Indenture (but need not confirm or investigate the accuracy of the mathematical calculations or other facts therein); 

(b)        the Trustee shall not be liable for any error of judgment made in good faith by a
Responsible Officer or Responsible Officers of the Trustee, unless it shall be determined in a final non-appealable judgment or order by a court of competent jurisdiction that the Trustee was negligent in
ascertaining the pertinent facts; 
 (c)        the Trustee shall not be liable with respect to any
action taken or omitted to be taken by it in good faith in accordance with the direction of the Holders pursuant to Section 4.09 relating to the time, method and place of conducting any proceeding for any remedy available to the Trustee, or
exercising any trust or power conferred upon the Trustee, under this Indenture; and 

(d)        under no circumstance shall the Trustee be liable in its individual capacity for the
obligations evidenced by the Securities. 
 None of the provisions contained in this Indenture shall require the Trustee to expend or risk
its own funds or otherwise incur personal financial liability in the performance of any of its duties or in the exercise of any of its rights or powers, if there shall be reasonable grounds for believing that the repayment of such funds or adequate
indemnity, security and/or pre-funding satisfactory to it in its sole discretion against such liability is not reasonably assured to it. 

The provisions of this Section 5.01 are in furtherance of and subject to Section 315 and Section 316 of the Trust Indenture
Act. 
 Section 5.02. Certain Rights of the Trustee. In furtherance of and subject
to the Trust Indenture Act, and subject to Section 5.01: 
 (a)        in the absence of
willful misconduct, negligence or bad faith on its part, the Trustee may conclusively rely and shall be protected in acting or refraining from acting upon any resolution, Officer’s Certificate or any other certificate, statement, instrument,
opinion, report, notice, request, consent, order, bond, debenture, note, coupon, security or other paper or document reasonably believed by it to be genuine and to have been signed or presented by the proper party or parties; 

  
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 (b)        any request, direction, order or demand
of the Company mentioned herein shall be sufficiently evidenced by an Officer’s Certificate (unless other evidence in respect thereof be herein specifically prescribed); and any Board Resolution may be evidenced to the Trustee by a copy thereof
certified by a Responsible Officer of the Company; 
 (c)        the Trustee may consult with
counsel, financial advisors and other professional advisors of its selection and any written advice or Opinion of Counsel shall be full and complete authorization and protection in respect of any action taken, suffered or omitted to be taken by it
hereunder in good faith and in accordance with such advice or Opinion of Counsel; 
 (d)        the
Trustee shall be under no obligation to exercise any of the trusts or powers vested in it by this Indenture at the request, order or direction of any of the Securityholders pursuant to the provisions of this Indenture, unless such Securityholders
shall have offered to the Trustee security, indemnity and/or pre-funding satisfactory to it in its sole discretion against the costs, expenses and liabilities which might be incurred therein or thereby; 

(e)        the Trustee shall not be liable for any action taken or omitted by it in good faith and
believed by it to be authorized or within the discretion, rights or powers conferred upon it by this Indenture; 

(f)        the Trustee shall not be bound to make any investigation into the facts or matters stated
in any resolution, certificate, statement, instrument, opinion, report, notice, request, consent, order, approval, appraisal, bond, debenture, note, coupon, security, or other paper or document unless requested in writing so to do by the Holders of
not less than a majority in aggregate principal amount of the Securities of all series affected then outstanding; provided that, if the payment within a reasonable time to the Trustee of the costs, expenses or liabilities likely to be incurred by it
in the making of such investigation is, in the opinion of the Trustee, not reasonably assured to the Trustee by the security afforded to it by the terms of this Indenture, the Trustee may require indemnity, security and/or pre-funding satisfactory
to it against such expenses or liabilities as a condition to proceeding; and the reasonable expenses of every such investigation shall be paid by the Company or, if paid by the Trustee, shall be repaid by the Company upon demand; 

(g)        the Trustee may execute any of the trusts or powers hereunder or perform any duties
hereunder either directly or by or through agents, delegates or attorneys not regularly in its employ and the Trustee shall not be responsible for any loss, liability, cost, claim, action, demand or expense incurred by reason of omissions,
misconduct or negligence on the part of any such agent, delegate or attorney appointed with due care by it hereunder; 

(h)        the Trustee shall not be deemed to have notice of any Event of Default (other than a
payment default under Section 4.01(a)) unless written notice of any event which is in fact such a default or Event of Default is received by a Responsible Officer of the Trustee at the Corporate Trust Office of the Trustee, and such notice
references the Securities and this Indenture; delivery to the Trustee of Company financial reports shall not be deemed to constitute actual knowledge or constructive knowledge by the Trustee of its contents or notice of a default or Event of
Default; 
 (i)        the Trustee may request that (and shall be entitled to receive) the Company
deliver an Officer’s Certificate setting forth the names of the respective individuals and titles of officers authorized at such time to take specified actions pursuant to this Indenture with their specimen signatures, which Officer’s
Certificate may be signed by any other person authorized to sign an Officer’s Certificate, including any person specified as so authorized in any such certificate previously delivered and not superseded; 

(j)        the permissive rights of the Trustee enumerated herein shall not be construed as duties;

 (k)        in no event shall the Trustee be responsible or liable for special, indirect,
punitive or consequential loss or damage of any kind whatsoever (including, but not limited to, loss of profit) whether or not 

  
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foreseeable irrespective of whether the Trustee was advised of the likelihood of such loss or damage and regardless of the form of action. The provisions of this Section 5.02(k) shall
survive the payment in full of the Securities, the termination or discharge of this Indenture and the resignation or removal of the Trustee; 

(l)        the Trustee shall not be responsible or liable for any failure or delay in the performance
of its obligations under this Indenture arising out of or caused, directly or indirectly, by circumstances beyond its reasonable control, including without limitation, acts of God; earthquakes; fires; floods; wars; civil or military disturbances;
sabotage; epidemics; riots; interruptions, loss or malfunctions of utilities, computer (hardware or software) or communications service; accidents; labor disputes; acts of civil or military authority or governmental actions; acts of terrorism;
failure of any money transmission currency exchange or SWIFT system; it being understood that the Trustee shall use its best efforts to resume performance as soon as practicable under the circumstances; 

(m)        the Trustee shall be entitled to take any action or to refuse to take any action which the
Trustee regards as necessary for the Trustee to comply with any applicable law, regulation or fiscal requirement, court order, or the rules, operating procedures or market practice of any relevant stock exchange or other market or clearing system;

 (n)        notwithstanding anything else contained in this Indenture, the Trustee may refrain
without liability from (i) doing anything which would or may in its opinion based upon advice of legal counsel be illegal or contrary to, or would result in the Trustee being in breach of, any law of any jurisdiction or any directive, rule,
regulation, request, direction, notice, announcement or similar action of any agency, regulatory authority, stock exchange or self-regulatory organization of any jurisdiction (including, without limitation, Section 619 of the Dodd-Frank Wall
Street Reform and Consumer Protection Act), or which would or might otherwise render it liable to any person and may do anything which is, in its opinion based upon advice of legal counsel, necessary to comply with any such law, directive or
regulation or (ii) doing anything which may cause the Trustee to be considered a sponsor of a covered fund under Section 619 of the Dodd-Frank Wall Street Reform and Consumer Protection Act and any regulations promulgated thereunder.
Furthermore, the Trustee may also refrain from taking any action if, in its opinion based upon advice of legal counsel, it would not have the power to do the relevant thing in the relevant jurisdiction by virtue of any applicable law in such
jurisdiction or if it is determined by any court or other competent authority in such jurisdiction that it does not have such power; 

(o)        the Trustee shall not be required to give any bond or surety in respect of the performance
of its powers and duties hereunder; 
 (p)        the Trustee shall treat information provided
hereunder as confidential, but (unless consent is prohibited by applicable law, regulatory authority, court or legal process) the Company hereby consents to the processing, transfer and disclosure by the Trustee of any information relating to it
provided hereunder to and between branches, subsidiaries, representative offices, affiliates and agents of the Trustee solely in connection with the discharge of the Trustee’s trusts, powers, authorities, duties and obligations hereunder,
wherever situated, for confidential use (including to service providers selected by the Trustee with due care for data processing, statistical and risk analysis purposes and for compliance with applicable law). The Trustee and any such branch,
subsidiary, representative office, affiliate, agent or third party, exercising due care, may transfer and disclose any such information only to the extent required or requested by any applicable law, regulatory authority, court or legal process,
including any auditor of the Company and including any payor or payee as required by applicable law, and may use (and its performance will be subject to the rules of) any communications, clearing or payment systems, intermediary bank or other
system. The Company acknowledges that the transfers permitted by this Section 5.02(p) may include transfers to jurisdictions which do not have strict data protection or data privacy laws; 

(q)        the Company hereby irrevocably waives, in favor of the Trustee, any conflict of interest
that may arise by virtue of the Trustee acting for other customers of the Trustee. The Company acknowledges 

  
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that the Trustee its respective affiliates (together, the “Trustee Parties”) may have interests in, or may be providing or may in the future provide financial or other services
to other parties with interests which the Company may regard as conflicting with its interests and may possess information (whether or not material to the Company) other than as a result of the Trustee acting as the Trustee hereunder, that the
Trustee may not be entitled to share with the Company. The Trustee and will not disclose confidential information obtained from the Company (without its consent) to any of the Trustee’s other customers or affiliates nor will it use on behalf of
the Company any confidential information obtained from any other customer. Without prejudice to the foregoing, the Company agrees that the Trustee Parties may deal (whether for its own or its customers’ account) in, or advise on, securities of
any party and that such dealing or giving of advice, will not constitute a conflict of interest for the purposes of the Securities or this Indenture; 

(r)        in the event the Trustee receives inconsistent or conflicting requests and indemnity,
security and/or pre-funding from two or more groups of Holders, each representing less than a majority in aggregate principal amount of the Outstanding Securities of each series affected, consistent with the
provisions of this Indenture, the Trustee may determine what action, if any, will be taken; 

(s)        in connection with the exercise by it of its trusts, powers, authorities or discretions
(including, without limitation, any modification, waiver, authorization or determination), the Trustee shall have regard to the general interests of the Holders of the Securities of each series affected as a class but shall not have regard to any
interests arising from circumstances particular to individual Holders (whatever their number) and in particular, but without limitation, shall not have regard to the consequences of the exercise of its trusts, powers, authorities or discretions for
individual Holders (whatever their number) resulting from their being for any purpose domiciled or resident in, or otherwise connected with, or subject to the jurisdiction of, any country, state or territory and a Holder shall not be entitled to
require, nor shall any Holder be entitled to claim, from the Company, the Trustee or any other Person any indemnification or payment in respect of any tax consequence of any such exercise upon individual Holders except to the extent already provided
in Section 3.05 and/or any undertaking given in addition to, or in substitution for, Section 3.05 pursuant to this Indenture; and 

(t)        all calculations relating to the Securities shall be performed by the Company or any other
person appointed by it for this purpose. The Trustee shall not be liable in any respect for the accuracy or inaccuracy in any calculation or formula hereunder or under the Securities, whether by the Company, the auditors or any other person so
appointed by any of them for such purpose. 
 Section 5.03. Trustee Not Responsible for
Recitals, Disposition of Securities or Application of Proceeds Thereof. The recitals contained herein and in the Securities, except the Trustee’s certificates of authentication, shall be taken as the statements of the Company, and
the Trustee assumes no responsibility for the correctness of the same. The Trustee makes no representation as to the validity or sufficiency of this Indenture or of the Securities. The Trustee shall not be accountable for the use or application by
the Company of any of the Securities or of the proceeds thereof, nor for the action or inaction of any Clearing Organization. 
 
Section 5.04. Trustee and Agents May Hold Securities; Collections, etc. The Trustee or any agent of the Company or the Trustee, in its individual or any other capacity, may become the owner or pledgee of Securities with the same
rights it would have if it were not the Trustee or such agent and may otherwise deal with the Company and receive, collect, hold and retain collections from the Company with the same rights it would have if it were not the Trustee or such agent.

 Section 5.05. Moneys Held by Trustee. Subject to the provisions of
Section 9.03 hereof, all moneys received by the Trustee shall, until used or applied as herein provided, be held in trust for the purposes for which they were received, but need not be segregated from other funds except to the extent required
by mandatory provisions of law. Neither the Trustee nor any agent of the Company or the Trustee shall be under any liability for interest on any moneys received by it hereunder, nor have any responsibility to invest such moneys, except as otherwise
agreed in writing by the Trustee with the Company. 

  
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 Section 5.06. Compensation and Indemnification
of Trustee and its Prior Claim. The Company covenants and agrees to pay to the Trustee from time to time, and the Trustee shall be entitled to, such reasonable compensation as the Company and the Trustee shall from time to time agree in
writing (which shall not be limited by any provision of law in regard to the compensation of a trustee of an express trust) and the Company covenants and agrees to pay or reimburse the Trustee and each predecessor trustee upon its request for all
properly incurred expenses, disbursements and advances incurred or made by or on behalf of it in accordance with any of the provisions of this Indenture (including, subject to Section 5.02(g) hereof, the reasonable compensation and the expenses
and disbursements of its counsel and of all agents and other persons not regularly in its employ) except to the extent any such expense, disbursement or advance may arise from its willful misconduct, negligence or bad faith as determined in a final non-appealable judgment or order by a court of competent jurisdiction. The Company also covenants to indemnify the Trustee, which for purposes of this Section 5.06 shall be deemed to include the Trustee’s
directors, officers, employees and agents, and each predecessor trustee (and their respective officers, employees, directors and agents) for, and to hold it harmless against, any loss, liability or expense (including taxes other than taxes based
upon the net income of the Trustee) arising out of or in connection with the acceptance or administration of this Indenture or the trusts hereunder and the performance of its duties hereunder, including the properly incurred costs and expenses
(including the properly incurred fees, charges and expenses of its agents and counsel) of defending itself against or investigating any claim of liability arising out of or in connection with the same, except to the extent such loss, liability or
expense may be attributable to the willful misconduct, negligence or bad faith of the Trustee, its agents, officers, directors or employees or such predecessor trustee, in each case as determined in a final
non-appealable judgment or order by a court of competent jurisdiction. The obligations of the Company under this Section to compensate and indemnify the Trustee and each predecessor trustee and to pay or
reimburse the Trustee and each predecessor trustee for expenses, disbursements and advances shall constitute additional indebtedness hereunder and shall survive the resignation or removal of the Trustee, the payment in full of the Securities and the
termination and discharge of this Indenture. Such additional indebtedness shall be a senior claim to that of the Securities upon all property and funds held or collected by the Trustee as such, except funds held in trust for the benefit of the
holders of particular Securities, and the Securities are hereby subordinated to such senior claim. 
 When the Trustee incurs expenses or
renders services in connection with an Event of Default specified in Section 4.01(d), the expenses (including the properly incurred fees and expenses of its agents and counsel) and the compensation for the services are intended to constitute
expenses of administration under any applicable bankruptcy, insolvency or other similar law. 
 The Trustee’s remuneration and that of
its agents and counsel is exclusive of value-added tax or any similar tax, which if applicable is also payable by the Company to the Trustee. All remuneration payable to the Trustee shall accrue interest from the date when payment was due. All
amounts payable to the Trustee shall be made without set-off, counterclaim, deduction or withholding unless required by law, in which case (other than in respect of taxes based upon, measured by or determined
by the income of the Trustee) the Company shall gross up such payments to the Trustee. 
 The indemnity set forth herein shall survive
final payment in full of the Securities, the termination or discharge of this Indenture, and the resignation or removal of the Trustee or any agent hereunder. 

Section 5.07. Right of Trustee to Rely on Officer’s Certificate, etc.
Subject to Sections 5.01 and 5.02, whenever in the administration of the trusts of this Indenture the Trustee shall deem it necessary or desirable that a matter be proved or established prior to taking or suffering or omitting any action hereunder,
such matter (unless other evidence in respect thereof be herein specifically prescribed) may, in the absence of willful misconduct, negligence or bad faith on the part of the Trustee, be deemed to be conclusively proved and established by an
Officer’s Certificate and/or an Opinion of Counsel delivered to the Trustee, and such certificate, in the absence of willful misconduct, negligence or bad faith on the part of the Trustee, shall be full warrant to the Trustee for any action
taken, suffered or omitted by it under the provisions of this Indenture to the extent of the Trustee’s reliance thereupon. 

  
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 Section 5.08. Persons Eligible for Appointment
as Trustee. The Trustee for each series of Securities hereunder shall at all times be a Person that is eligible in accordance with the provisions of Section 310(a) of the Trust Indenture Act to act as such and has a combined capital
and surplus of at least $50,000,000. If such corporation publishes reports of condition at least annually, pursuant to law or to the requirements of any supervising or examining authority, then for the purposes of this Section, the combined capital
and surplus of such corporation shall be deemed to be its combined capital and surplus as set forth in its most recent report of condition so published. If at any time the Trustee or any trustee hereafter appointed shall cease to be eligible in
accordance with the provisions of this Section, it shall resign immediately in the manner and with the effect specified in Section 5.09. 

Section 5.09. Resignation and Removal; Appointment of Successor Trustee. (a) The
Trustee, or any trustee or trustees hereafter appointed, may at any time resign with respect to one or more or all series of Securities by giving 60 days written notice of resignation to the Company and by mailing notice thereof by first-class mail
to Holders of the applicable series of Securities at their last addresses as they shall appear on the Register or otherwise providing notice to Holders in the manner applicable to the Securities of each series. Upon receiving such notice of
resignation, the Company shall promptly appoint a successor trustee or trustees with respect to the applicable series by written instrument in duplicate, executed by authority of the Board, one copy of which instrument shall be delivered to the
resigning Trustee and one copy to the successor trustee or trustees. If no successor trustee shall have been so appointed with respect to any series and have accepted appointment within 30 days after the mailing of such notice of resignation or
removal (as the case may be), the resigning trustee may, on behalf of and at the expense of the Company, appoint its successor or the resigning Trustee may petition any court of competent jurisdiction for the appointment of a successor trustee, or
any Securityholder who has been a bona fide Holder of a Security or Securities of the applicable series for at least six months may, subject to the provisions of Section 4.12, on behalf of himself and all others similarly situated, petition any
such court for the appointment of a successor trustee. Such court may thereupon, after such notice, if any, as it may deem proper and prescribe, appoint a successor trustee. 

(b)        In case at any time any of the following shall occur: 

(i)        the Trustee shall fail to comply with the provisions of
Section 310(b) of the Trust Indenture Act with respect to any series of Securities and shall fail to resign after written request therefor by the Company or by any Securityholder who has been a bona fide Holder of a Security or Securities of
such series for at least six months; or 
 (ii)        the Trustee shall cease to
be eligible in accordance with the provisions of Section 310(a) of the Trust Indenture Act and shall fail to resign after written request therefor by the Company or by any Securityholder; or 

(iii)        the Trustee shall become incapable of acting with respect to any series
of Securities, or shall be adjudged a bankrupt or insolvent, or a receiver or liquidator of the Trustee or of its property shall be appointed, or any public officer shall take charge or control of the Trustee or of its property or affairs for the
purpose of rehabilitation, conservation or liquidation; 
 then, in any such case, the Company shall remove the Trustee with respect to the
applicable series of Securities and appoint a successor trustee for such series by written instrument, in duplicate, executed by order of the Board, one copy of which instrument shall be delivered to the Trustee so removed and one copy to the
successor trustee, or, subject to Section 315(e) of the Trust Indenture Act, any Securityholder who has been a bona fide Holder of a Security or Securities of such series for at least six months may, on behalf of himself and all others
similarly situated, petition any court of competent jurisdiction for the removal of the Trustee and the appointment of a successor trustee with respect to such series. Such court may 

  
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thereupon, after such notice, if any, as it may deem proper and prescribe, remove the Trustee and appoint a successor trustee. 

(c)        The Holders of a majority in aggregate principal amount of the Securities of each series
at the time Outstanding may at any time remove the Trustee with respect to Securities of such series and appoint a successor trustee with respect to the Securities of such series by delivering to the Trustee so removed, to the successor trustee so
appointed and to the Company the evidence provided for in Section 6.01 of the action in that regard taken by the Securityholders. 

(d)        Any resignation or removal of the Trustee with respect to any series and any appointment
of a successor trustee with respect to such series pursuant to any of the provisions of this Section 5.09 shall become effective upon acceptance of appointment by the successor trustee as provided in Section 5.10. 

Section 5.10. Acceptance of Appointment by Successor Trustee. Any successor trustee
appointed as provided in Section 5.09 shall execute and deliver to the Company and to its predecessor trustee an instrument accepting such appointment hereunder, and thereupon the resignation or removal of the predecessor trustee with respect
to all or any applicable series shall become effective and such successor trustee, without any further act, deed or conveyance, shall become vested with all rights, powers, duties and obligations with respect to such series of its predecessor
hereunder, with like effect as if originally named as trustee for such series hereunder; but, nevertheless, on the written request of the Company or of the successor trustee, upon payment of its charges then unpaid, the trustee ceasing to act shall,
subject to Section 9.03, pay over to the successor trustee all moneys at the time held by it hereunder and shall execute and deliver an instrument transferring to such successor trustee all such rights, powers, duties and obligations. Upon
request of any such successor trustee, the Company shall execute any and all instruments in writing for more fully and certainly vesting in and confirming to such successor trustee all such rights and powers. Any trustee ceasing to act shall,
nevertheless, retain a prior claim upon all property or funds held or collected by such trustee to secure any amounts then due it pursuant to the provisions of Section 5.06. 

If a successor trustee is appointed with respect to the Securities of one or more (but not all) series, the Company, the predecessor trustee
and each successor trustee with respect to the Securities of any applicable series shall execute and deliver an indenture supplemental hereto which shall contain such provisions as (i) shall be necessary or desirable to transfer and confirm to,
and to vest in, each successor trustee all the rights, powers, trusts and duties of the retiring Trustee with respect to the Securities of that or those series to which the appointment of such successor trustee relates, (ii) shall be deemed
necessary or desirable to confirm that all the rights, powers, trusts and duties of the predecessor trustee with respect to the Securities of any series as to which the predecessor trustee is not retiring shall continue to be vested in the
predecessor trustee, and (iii) shall add to or change any of the provisions of this Indenture as shall be necessary to provide for or facilitate the administration of the trusts hereunder by more than one trustee, it being understood that
nothing herein or in such supplemental indenture shall constitute such trustees co-trustees of the same trust and that each such trustee shall be trustee of a trust or trusts under separate indentures; and
upon the execution and delivery of such supplemental indenture the resignation or removal of the predecessor trustee shall become effective to the extent provided therein and such successor trustee, without any further act, deed or conveyance, shall
become vested with all rights, powers, duties and obligations with respect to such series of its predecessor hereunder, with like effect as if originally named as trustee for such series hereunder; but, nevertheless, on the written request of the
Company or of the successor trustee, upon payment of its charges then unpaid, the trustee ceasing to act shall, subject to Section 9.03, pay over to the successor trustee all moneys at the time held by it hereunder and shall execute and deliver
an instrument transferring to such successor trustee all such rights, powers, duties and obligations. 
 No successor trustee shall accept
its appointment unless at the time of such acceptance such successor trustee for the Securities of any series is eligible pursuant to Section 5.08 hereof. 

  
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 Upon acceptance of appointment by any successor trustee as provided in this
Section 5.10, the Company shall mail notice thereof by first-class mail to the Holders of Securities of any series for which such successor trustee is acting as trustee at their last addresses as they shall appear in the Register or shall
otherwise provide notice thereof to Holders in the manner applicable to the Securities of each series. If the acceptance of appointment is substantially contemporaneous with the resignation, then the notice called for by the preceding sentence may
be combined with the notice called for by Section 5.09. If the Company fails to mail or provide such notice within ten days after acceptance of appointment by the successor trustee, the successor trustee shall cause such notice to be mailed or
provided at the expense of the Company. 
 Section 5.11. Merger, Conversion, Consolidation or
Succession to Business of Trustee. Any corporation into which the Trustee may be merged or converted or with which it may be consolidated, or any corporation resulting from any merger, conversion or consolidation to which the Trustee
shall be a party, or any corporation succeeding to all or substantially all of the corporate trust business of the Trustee, shall be the successor of the Trustee hereunder, provided that such corporation shall be eligible under the provisions of
Section 5.08, without the execution or filing of any paper or any further act on the part of any of the parties hereto, anything herein to the contrary notwithstanding. 

In case at the time such successor to the Trustee shall succeed to the trusts created by this Indenture and any of the Securities of any
series shall have been authenticated but not delivered, any such successor to the Trustee may adopt the certificate of authentication of any predecessor trustee and deliver such Securities so authenticated; and, in case at that time any of the
Securities of any series shall not have been authenticated, any successor to the Trustee may authenticate such Securities either in the name of any predecessor hereunder or in the name of the successor trustee; and in all such cases such certificate
shall have the full force which it is anywhere in the Securities of such series or in this Indenture provided that the certificate of the Trustee shall have; provided, that the right to adopt the certificate of authentication of any predecessor
trustee or to authenticate Securities of any series in the name of any predecessor trustee shall apply only to its successor or successors by merger, conversion or consolidation. 

Section 5.12. Conflicting Interests. The Trustee for the Securities shall be subject to the
provisions of Section 310(b) of the Trust Indenture Act during the period of time required thereby. Nothing herein shall prevent the Trustee from filing with the Commission the application referred to in the penultimate paragraph of
Section 310(b) of the Trust Indenture Act. In determining whether the Trustee has a conflicting interest as defined in Section 310(b) of the Trust Indenture Act with respect to the Securities of any series, there shall be excluded
Securities of any particular series of Securities other than that series. 

Section 5.13. Appointment of Authenticating Agent. The Trustee may appoint an
Authenticating Agent or agents with respect to one or more series of Securities which shall be authorized to act on behalf of the Trustee to authenticate Securities of such series, and Securities so authenticated shall be entitled to the benefits of
this Indenture and shall be valid and obligatory for all purposes as if authenticated by the Trustee hereunder. Wherever reference is made in this Indenture to the authentication and delivery of Securities by the Trustee or the Trustee’s
certificate of authentication, such reference shall be deemed to include authentication and delivery on behalf of the Trustee by an Authenticating Agent and a certificate of authentication executed on behalf of the Trustee by an Authenticating
Agent. Each Authenticating Agent shall be acceptable to the Company and shall at all times be a Person that is eligible pursuant to the Trust Indenture Act to act as Authenticating Agent, having a combined capital and surplus of not less than
$50,000,000. If such Authenticating Agent publishes reports of condition at least annually, pursuant to law or to the requirements of any supervising or examining authority, then for the purposes of this Section, the combined capital and surplus of
such Authenticating Agent shall be deemed to be its combined capital and surplus as set forth in its most recent report of condition so published. If at any time an Authenticating Agent shall cease to be eligible in accordance with the provisions of
this Section, such Authenticating Agent shall resign immediately in the manner and with the effect specified in this Section. 
 Any
corporation into which an Authenticating Agent may be merged or converted or with which it may be consolidated, or any corporation resulting from any merger, conversion or consolidation to 

  
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which such Authenticating Agent shall be a party, or any corporation succeeding to the corporate agency or corporate trust business of an Authenticating Agent, shall continue to be an
Authenticating Agent, provided such corporation shall be otherwise eligible under this Section, without the execution or filing of any paper or any further act on the part of the Trustee or the Authenticating Agent. 

An Authenticating Agent may resign at any time by giving written notice thereof to the Trustee and to the Company. The Trustee may at any
time terminate the agency of an Authenticating Agent by giving written notice thereof to such Authenticating Agent and to the Company. Upon receiving such a notice of resignation or upon such a termination, or in case at any time such Authenticating
Agent shall cease to be eligible in accordance with the provisions of this Section, the Trustee may appoint a successor Authenticating Agent which shall be acceptable to the Company and shall mail written notice of such appointment by first-class
mail, postage prepaid, to all Holders of Securities of the series with respect to which such Authenticating Agent will serve, as their names and addresses appear in the Register of the Company. 

Any successor Authenticating Agent upon acceptance of its appointment hereunder shall become vested with all the rights, powers and duties of
its predecessor hereunder, with like effect as if originally named as an Authenticating Agent. No successor Authenticating Agent shall be appointed unless eligible under the provisions of this Section. 

The Company agrees to pay to each Authenticating Agent from time to time such reasonable compensation for its services under this Section as
may be agreed between the Company and such Authenticating Agent. 
 If an appointment with respect to one or more series is made pursuant
to this Section, the Securities of such series may have endorsed thereon, in addition to the Trustee’s certificate of authentication, an alternate certificate of authentication in the following form: 

Certificate of Authentication: 
 This is one of the
Securities of the series designated herein referred to in the within-mentioned Indenture. 
  

									
	Date:	 	  
	 		 	
		 		 		 	Citibank, N.A.
		 		 		 	as Trustee
					
	     
	 	                                     
                           	 		 	 By:
	 	  

		 		 		 		 	 Name:

		 		 		 		 	 Title:

Section 5.14. Reports by the Trustee. Any Trustee’s report required under
Section 313(a) of the Trust Indenture Act shall be transmitted on or before April 1 in each year following the date hereof, so long as any Securities are Outstanding hereunder, and shall be dated as of a date convenient to the Trustee no
more than 60 nor less than 45 days prior thereto. A copy of each such report shall, at the time of such transmission to Holders, be filed by the Trustee with any securities exchange in the United States on which any Securities are listed, with the
Commission and with the Company. 
 ARTICLE 6 

CONCERNING THE SECURITYHOLDERS 
 
Section 6.01. Evidence of Action Taken by Securityholders. Any request, demand, authorization, direction, notice, consent, waiver or other action provided by this Indenture to be given or taken by a specified percentage
in principal amount of the Securityholders of any or all series may be embodied in and 

  
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evidenced by one or more instruments of substantially similar tenor signed by such specified percentage of Securityholders in person or by agent duly appointed in writing; and, except as herein
otherwise expressly provided, such action shall become effective when such instrument or instruments are delivered to the Trustee. Proof of execution of any instrument or of a writing appointing any such agent shall be sufficient for any purpose of
this Indenture and (subject to Sections 5.01 and 5.02) conclusive in favor of the Trustee and the Company, if made in the manner provided in this Article. 

Section 6.02. Proof of Execution of Instruments and of Holding of Securities; Record
Date. Subject to Sections 5.01 and 5.02, the execution of any instrument by a Securityholder or his agent or proxy may be proved in accordance with such reasonable rules and regulations as may be prescribed by the Trustee or in such
manner as shall be satisfactory to the Trustee. The holding of Securities shall be proved by the Register or by a certificate of the Registrar thereof. The Company may set a record date for purposes of determining the identity of holders of
Securities of any series entitled to vote or consent to any action referred to in Section 6.01, which record date may be set at any time or from time to time by notice to the Trustee, for any date or dates (in the case of any adjournment or
reconsideration) not more than 60 days nor less than ten days prior to the proposed date of such vote or consent, and thereafter, notwithstanding any other provisions hereof, only holders of Securities of such series of record on such record date
shall be entitled to so vote or give such consent or revoke such vote or consent; provided that no such action shall be effective hereunder unless taken on or prior to the applicable Expiration Date by Holders of the requisite principal amount of
Outstanding Securities of such series on such record date. With respect to any record date set pursuant to this Section, the Company may designate any day as the “Expiration Date” and from time to time may change the Expiration Date
to any earlier or later day; provided that no such change shall be effective unless notice of the proposed new Expiration Date is given to the Trustee in writing, and to each Holder of Securities of the relevant series in the manner set forth in
Section 10.04, on or prior to the existing Expiration Date. If an Expiration Date is not designated with respect to any record date set pursuant to this Section, the Company shall be deemed to have initially designated the 180th day after such
record date as the Expiration Date with respect thereto, subject to its right to change the Expiration Date as provided in this paragraph. Notwithstanding the foregoing, no Expiration Date shall be later than the 180th day after the applicable
record date. 
 Section 6.03. Holders to be Treated as Owners. The Company, the
Trustee and any agent of the Company or the Trustee may deem and treat the person in whose name any Security shall be registered upon the Register for such series as the absolute owner of such Security (whether or not such Security shall be overdue
and notwithstanding any notation of ownership or other writing thereon) for the purpose of receiving payment of or on account of the principal of and, subject to the provisions of this Indenture, interest on such Security and for all other purposes;
and neither the Company, the Trustee nor any agent of the Company or the Trustee shall be affected by any notice to the contrary. All such payments so made to any such person, or upon his order, shall be valid, and, to the extent of the sum or sums
so paid, effectual to satisfy and discharge the liability for moneys payable upon any such Security. 

Section 6.04. Securities Owned by Company Deemed Not Outstanding. In determining
whether the Holders of the requisite aggregate principal amount of Outstanding Securities of any or all series have concurred in any direction, consent or waiver under this Indenture, Securities which are owned by the Company or any other obligor on
the Securities with respect to which such determination is being made or by any person directly or indirectly controlling or controlled by or under direct or indirect common control with the Company or any other obligor on the Securities with
respect to which such determination is being made shall be disregarded and deemed not to be Outstanding for the purpose of any such determination, except that for the purpose of determining whether the Trustee shall be protected in relying on any
such direction, consent or waiver only Securities in respect of which a Responsible Officer of the Trustee has received written notice shall be so disregarded. Securities held by any depositary or other custodial arrangement established by or on
behalf of the Company shall be regarded as Outstanding if the beneficial interest therein is not owned by the Company or any other obligor on such Securities or by any Person directly or indirectly controlling or controlled by or under direct or
indirect common control with the Company or any other obligor on such Securities. Securities so owned 

  
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which have been pledged in good faith may be regarded as Outstanding if the pledgee establishes to the satisfaction of the Trustee the pledgee’s right so to act with respect to such
Securities and that the pledgee is not the Company or any other obligor upon the Securities or any person directly or indirectly controlling or controlled by or under direct or indirect common control with the Company or any other obligor on the
Securities. In case of a dispute as to such right, the advice of counsel shall be full protection in respect of any reasonable decision made by the Trustee in accordance with such advice. Upon request of the Trustee, the Company shall furnish to the
Trustee promptly an Officer’s Certificate listing and identifying all Securities, if any, known by the Company to be owned or held by or for the account of any of the above-described persons; and, subject to Sections 5.01 and 5.02, the Trustee
shall be entitled to accept such Officer’s Certificate as conclusive evidence of the facts therein set forth and of the fact that all Securities not listed therein are Outstanding for the purpose of any such determination. 

Section 6.05. Right of Revocation of Action Taken. At any time prior to (but not
after) the evidencing to the Trustee, as provided in Section 6.01, of the taking of any action by the Holders of the percentage in aggregate principal amount of the Securities of any or all series, as the case may be, specified in this
Indenture in connection with such action, any Holder of a Security the serial number of which is shown by the evidence to be included among the serial numbers of the Securities the Holders of which have consented to such action may, by filing
written notice at the Corporate Trust Office and upon proof of holding as provided in this Article, revoke such action so far as concerns such Security. Except as aforesaid, any such action taken by the Holder of any Security shall be conclusive and
binding upon such Holder and upon all future Holders and owners of such Security and of any Securities issued in exchange or substitution therefor or on registration of transfer thereof, irrespective of whether or not any notation in regard thereto
is made upon any such Security. Any action taken by the Holders of the percentage in aggregate principal amount of the Securities of any or all series, as the case may be, specified in this Indenture in connection with such action shall be
conclusively binding upon the Company, the Trustee and the Holders of all the Securities affected by such action. 
 ARTICLE 7 

SUPPLEMENTAL INDENTURES 
 
Section 7.01. Supplemental Indentures Without Consent of Securityholders. The Company, when authorized by a Board Resolution, and the Trustee may, from time to time, and at any time enter into an indenture or indentures
supplemental hereto for one or more of the following purposes: 
 (a)        to evidence the
succession of another legal entity to the Company, or successive successions, and the assumption by a successor legal entity of the covenants, agreements and obligations of the Company pursuant to Article 8; 

(b)        to add to the covenants of the Company such further covenants, restrictions, conditions or
provisions as the Company shall consider to be for the protection of the Holders of Securities, and to make the occurrence, or the occurrence and continuance, of a default in any such additional covenants, restrictions, conditions or provisions an
Event of Default permitting the enforcement of all or any of the several remedies provided in this Indenture as herein set forth; provided, that in respect of any such additional covenant, restriction, condition or provision such supplemental
indenture may provide for a particular period of grace after default (which period may be shorter or longer than that allowed in the case of other defaults) or may provide for an immediate enforcement upon such an Event of Default or may limit the
remedies available to the Trustee upon such an Event of Default or may limit the right of the Holders of a majority in aggregate principal amount of the Securities of such series to waive such an Event of Default; 

(c)        to cure any ambiguity or to correct or supplement any provision contained herein or in any
supplemental indenture which may be defective or inconsistent with any other provision contained herein or in any supplemental indenture; or to make such other provisions in regard to matters or questions arising under this Indenture or under any
supplemental indenture as the Board may deem necessary or desirable and which shall not adversely affect the interests of the Holders of the Securities in any material respect; 

  
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 (d)        to add to, change or eliminate any of
the provisions (other than as noted in Section 7.02) of this Indenture, provided, however, that any such addition, change or elimination shall not adversely affect the interests of the Holders of the Securities in any material respect; 

(e)        to add to, change or eliminate any of the provisions of this Indenture for the purpose of
reflecting any change in the procedures relating to Japanese withholding tax resulting from any amendment to the applicable Japanese tax law, provided that such amendment is relevant to any series of Securities; 

(f)        to establish the form or terms of Securities of any series as permitted by
Section 2.01 and Section 2.03; or 
 (g)        to evidence and provide for the
acceptance of appointment hereunder by a successor trustee with respect to the Securities of one or more series and to add to or change any of the provisions of this Indenture as shall be necessary to provide for or facilitate the administration of
the trusts hereunder by more than one trustee, pursuant to the requirements of Section 5.10. 
 The Trustee is hereby authorized to
join with the Company in the execution of any such supplemental indenture, to make any further appropriate agreements and stipulations which may be therein contained and to accept the conveyance, transfer, assignment, mortgage or pledge of any
property thereunder, but the Trustee shall not be obligated to enter into any such supplemental indenture which affects the Trustee’s own rights, duties or immunities under this Indenture or otherwise. The Trustee, at the expense of the
Company, shall be entitled to receive an Officer’s Certificate and an Opinion of Counsel with regard to any such supplemental indenture. The Trustee shall be entitled to conclusively rely upon such Officer’s Certificate and Opinion of
Counsel in entering into such supplemental indenture. The Opinion of Counsel shall comply with Section 10.05 and confirm (inter alia) that the supplemental indenture is authorized or permitted under this Indenture, and that it is legal,
valid, binding and enforceable against the Company under New York law. 
 Any supplemental indenture authorized by the provisions of this
Section may be executed without the consent of the Holders of any of the Securities at the time outstanding, notwithstanding any of the provisions of Section 7.02. 

Section 7.02. Supplemental Indentures With Consent of Securityholders. With the
consent (evidenced as provided in Article 6) of the Holders of not less than a majority in aggregate principal amount of the Securities at the time Outstanding of all series affected by such supplemental indenture (with each such series voting as
one class), the Company, when authorized by a resolution of its Board, and the Trustee may, from time to time and at any time, enter into an indenture or indentures supplemental hereto for the purpose of adding any provisions to or changing in any
manner or eliminating any of the provisions of this Indenture or of any supplemental indenture or of modifying in any manner the rights of the Holders of the Securities of each such series; provided, that no such supplemental indenture shall
(1) change the stated maturity of the principal of, or any installment of principal of or interest on, any Security, or reduce the principal amount thereof or the rate of interest thereon or any premium payable upon the redemption thereof, or
reduce the amount of the principal of an Original Issue Discount Security or any other Security which would be due and payable upon a declaration of acceleration of the maturity thereof pursuant to Section 4.01, or change any Place of Payment
where, or the coin or currency in which, any Security or any premium or interest thereon is payable, or impair the right to institute suit for the enforcement of any such payment on or after the stated maturity thereof (or, in the case of
redemption, on or after the redemption date), (2) reduce the percentage in principal amount of any Outstanding Securities (considered separately or together as one class, as applicable, and whether comprising the same or different series or less
than all the Securities of a series), the consent of whose Holders is required for any such supplemental indenture, or the consent of whose Holders is required for any waiver (of compliance with certain provisions of this Indenture or certain
defaults hereunder and their consequences) provided for in this Indenture, (3) modify any of the provisions of this Section or Section 4.10, except to increase any such percentage or to provide that certain other provisions of this
Indenture cannot be modified or waived without the consent of the 

  
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Holder of each Outstanding Security affected thereby; provided, however, that this clause shall not be deemed to require the consent of any Holder with respect to changes in the references to
“the Trustee” and concomitant changes in this Section, or the deletion of this proviso, in accordance with the requirements of Sections 5.10 and 7.01, or (4) change in any manner adverse to the interests of the Holders of Securities
the terms and conditions of the obligations of the Company in respect of the due and prompt payment of the principal thereof (and premium, if any) and interest thereon, or Additional Amounts with respect thereto, without the consent of the Holders
of each Security so affected. 
 A supplemental indenture which changes or eliminates any covenant or other provision of this Indenture
which has expressly been included solely for the benefit of one or more particular series of Securities, or which modifies the rights of holders of Securities of such series, with respect to such covenant or provision, shall be deemed not to affect
the rights under this Indenture of the holders of Securities of any other series. 
 Upon the request of the Company, accompanied by a copy
of the Board Resolution certified by a Responsible Officer of the Company authorizing the execution of any such supplemental indenture, and upon the filing with the Trustee of evidence of the consent of Securityholders as aforesaid and other
documents, if any, required by Section 6.01, the Trustee shall join with the Company in the execution of such supplemental indenture unless such supplemental indenture affects the Trustee’s own rights, duties or immunities under this
Indenture or otherwise, in which case the Trustee may in its discretion, but shall not be obligated to, enter into such supplemental indenture. The Trustee, at the expense of the Company, shall be entitled to receive an Officer’s Certificate
and an Opinion of Counsel with regard to any such supplemental indenture. The Trustee shall be entitled to conclusively rely upon such Officer’s Certificate and Opinion of Counsel in entering into such supplemental indenture. The Opinion of
Counsel shall comply with Section 10.05 and confirm (inter alia) that the supplemental indenture is authorized or permitted under this Indenture, and that it is legal, valid, binding and enforceable against the Company under New York
law. 
 It shall not be necessary for the consent of the Securityholders under this Section to approve the particular form of any proposed
supplemental indenture, but it shall be sufficient if such consent shall approve the substance thereof. 
 Promptly after the execution by
the Company and the Trustee of any supplemental indenture pursuant to the provisions of this Section, the Company shall give notice thereof by (a) first-class mail to the Holders of Securities of each series affected thereby at their addresses
as they shall appear on the Register of the Company or (b) by any other means set forth in such supplemental indenture, setting forth in general terms the substance of such supplemental indenture. The Trustee shall assist the Company with the
distribution of the notices to the Holders. Any failure of the Company to mail such notice, or any defect therein, shall not, however, in any way impair or affect the validity of any such supplemental indenture. 

Section 7.03. Effect of Supplemental Indenture. Upon the execution of any
supplemental indenture pursuant to the provisions hereof, this Indenture shall be and be deemed to be modified and amended in accordance therewith and the respective rights, limitations of rights, obligations, duties and immunities under this
Indenture of the Trustee, the Company and the Holders of Securities of each series affected thereby shall thereafter be determined, exercised and enforced hereunder subject in all respects to such modifications and amendments, and all the terms and
conditions of any such supplemental indenture shall be and be deemed to be part of the terms and conditions of this Indenture for any and all purposes. 

Section 7.04. Documents to be Given to Trustee. The Trustee, subject to the
provisions of Sections 5.01 and 5.02, shall be entitled to receive, in addition to the documents required by Section 10.05, an Officer’s Certificate and an Opinion of Counsel each stating that, and as conclusive evidence that, any
supplemental indenture executed pursuant to this Article 7 complies with the applicable provisions of this Indenture. 

  
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 Section 7.05. Notation on Securities in
Respect of Supplemental Indentures. Securities of any series authenticated and delivered after the execution of any supplemental indenture pursuant to the provisions of this Article may bear a notation in form approved by the Trustee for
such series as to any matter provided for by such supplemental indenture or as to any action taken by Securityholders. If the Company or the Trustee shall so determine, new Securities of any series so modified as to conform, in the opinion of the
Board, to any modification of this Indenture contained in any such supplemental indenture may be prepared by the Company, authenticated by the Trustee and delivered in exchange for the Securities of such series then Outstanding. 

Section 7.06. Conformity with the Trust Indenture Act. Every supplemental indenture executed
pursuant to this Article 7 shall conform to the requirements of the Trust Indenture Act as then in effect. 
 ARTICLE 8 

CONSOLIDATION, MERGER, SALE OR CONVEYANCE 

Section 8.01. Company May Consolidate, etc., on Certain Terms. The Company shall not
consolidate with or merge into any other Person or convey, transfer or lease its properties and assets substantially as an entirety to any Person, unless: 

(a)        in case the Company shall consolidate with or merge into another Person or convey,
transfer or lease its properties and assets substantially as an entirety to any Person, the Person formed by such consolidation or into which the Company is merged or the Person which acquires by conveyance or transfer, or which leases, the
properties and assets of the Company substantially as an entirety shall be a corporation, partnership or trust, shall be organized and validly existing under the laws of any domestic or foreign jurisdiction and shall expressly assume, by an
indenture supplemental hereto, executed and delivered to the Trustee, in form satisfactory to the Trustee, the due and punctual payment of the principal of and any premium and interest on all the Securities, and the performance or observance of
every covenant of this Indenture on the part of the Company to be performed or observed; and 

(b)        immediately after giving effect to such transaction, no Event of Default, and no event
which, after notice or lapse of time or both, would become an Event of Default, shall have occurred and be continuing. 
 The Company shall
deliver to the Trustee before the consummation of such proposed transaction an Officer’s Certificate to the foregoing effect and an Opinion of Counsel to the effect that (i) such consolidation, merger, conveyance, transfer or lease and
such supplemental indenture, comply with this Indenture, (ii) the surviving Person has duly executed and delivered the supplemental indenture and (iii) such supplemental indenture constitutes a valid and binding agreement of such Person,
enforceable against such Person in accordance with its terms. The Trustee shall be entitled to rely conclusively upon such Officer’s Certificate and Opinion of Counsel. 

Section 8.02. Successor Substituted. In case of any such consolidation, merger, sale
or conveyance, and following such an assumption by the successor legal entity, such successor legal entity shall succeed to and be substituted for the Company, with the same effect as if it had been named herein. Such successor legal entity may
cause to be signed, and may issue either in its own name or in the name of the Company prior to such succession, any or all of the Securities issuable hereunder which theretofore shall not have been signed by the Company and delivered to the
Trustee; and, upon the order of such successor legal entity instead of the Company and subject to all the terms, conditions and limitations in this Indenture prescribed, the Trustee shall authenticate and shall deliver any Securities which
previously shall have been signed and delivered by the officers of the Company to the Trustee for authentication, and any Securities which such successor legal entity thereafter shall cause to be signed and delivered to the Trustee for that purpose.
All of the Securities so issued shall in all respects have the same legal rank and benefit under this Indenture as the Securities theretofore or thereafter issued in accordance with the terms of this Indenture as though all of such Securities had
been issued at the date of the execution hereof. 

  
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 In case of any such consolidation, merger, sale, lease or conveyance such changes in
phrasing and form (but not in substance) may be made in the Securities thereafter to be issued as may be appropriate. 
 In the event of
any such sale or conveyance (other than a conveyance by way of lease) the Company or any successor legal entity which shall theretofore have become such in the manner described in this Article shall be discharged from all obligations and covenants
under this Indenture and the Securities and may be liquidated and dissolved. 

Section 8.03. Opinion of Counsel to Trustee. The Trustee, subject to the provisions
of Section 5.01 and Section 5.02, shall be entitled to receive an Opinion of Counsel, prepared in accordance with Section 10.05, as conclusive evidence that any such consolidation, merger, sale, lease or conveyance, and any such
assumption, and any such liquidation or dissolution, complies with the applicable provisions of this Indenture. 
 ARTICLE 9 

SATISFACTION AND DISCHARGE OF INDENTURE; UNCLAIMED MONEYS 

Section 9.01. Satisfaction and Discharge of Indenture. When (i) the Company has
paid or caused to be paid the principal of and interest on all the Securities of any series Outstanding hereunder (other than Securities of such series which have been destroyed, lost or stolen and which have been replaced or paid as provided in
Section 2.09) as and when the same shall have become due and payable, or (ii) the Company shall have delivered to the Paying Agent for cancellation all Securities of any series theretofore authenticated (other than any Securities of such
series which shall have been destroyed, lost or stolen and which shall have been replaced or paid as provided in Section 2.09); this Indenture shall cease to be of further effect with respect to Securities of such series, and the Trustee, on
prior written demand of the Company accompanied by an Officer’s Certificate and an Opinion of Counsel and at the cost and expense of the Company, shall execute proper instruments acknowledging such satisfaction of and discharging this Indenture
with respect to such series; provided, that the rights of Holders of the Securities to receive amounts in respect of principal of and interest on the Securities held by them shall not be delayed longer than required by then-applicable
mandatory rules or policies of any securities exchange upon which the Securities are listed. The Company agrees to reimburse the Trustee for any costs or expenses thereafter properly incurred and to compensate the Trustee for any services thereafter
properly rendered by the Trustee in connection with this Indenture or the Securities of such series. 

Section 9.02. Application by Trustee of Funds Deposited for Payment of Securities.
Subject to Section 9.03 and any subordination provisions applicable to the Securities, all moneys deposited with the Trustee shall be held in trust and applied by it to the payment, either directly or through any Paying Agent (including the
Company acting as its own Paying Agent), to the Holders of the particular Securities of such series for the payment or redemption of which such moneys have been deposited with the Trustee of all sums due and to become due thereon for principal and
interest pursuant to such Securities and this Indenture; but such money need not be segregated from other funds except to the extent required by law. 

Section 9.03. Repayment of Moneys Held by Paying Agent. In connection with the
satisfaction and discharge of this Indenture with respect to Securities of any series, all moneys then held by any Paying Agent under the provisions of this Indenture with respect to such series of Securities shall, upon demand of the Company, be
repaid to it or paid to the Trustee and thereupon such Paying Agent shall be released from all further liability with respect to such moneys. 

Section 9.04. Return of Moneys Held by Trustee and Paying Agent Unclaimed for Two Years.
Any moneys deposited with or paid to the Trustee or any Paying Agent for the payment of the principal of or interest on any Security of any series and not applied but remaining unclaimed for two years after the date upon which such principal or
interest shall have become due and payable, shall, upon the prior written request of the Company and unless otherwise required by mandatory provisions of applicable escheat or abandoned or 

  
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unclaimed property law, be repaid to the Company by the Trustee for such series or such Paying Agent, and the Holder of the Security of such series shall, unless otherwise required by mandatory
provisions of applicable escheat or abandoned or unclaimed property laws, thereafter look only to the Company for any payment which such Holder may be entitled to collect, and all liability of the Trustee or any Paying Agent with respect to such
moneys shall thereupon cease. 
 ARTICLE 10 

MISCELLANEOUS PROVISIONS 
 
Section 10.01. Incorporators, Stockholders, Officers and Directors of Company Exempt from Individual Liability. No recourse under or upon any obligation, covenant or agreement contained in this Indenture, or in any
Security, or because of any indebtedness evidenced thereby, shall be had against any incorporator, as such, or against any past, present or future stockholder, member, officer, director or employee, as such, of the Company, or of any successor,
either directly or through the Company or any successor, under any rule of law, statute or constitutional provision or by the enforcement of any assessment or by any legal or equitable proceeding or otherwise, all such liability being expressly
waived and released by the acceptance of the Securities by the holders thereof and as part of the consideration for the issue of the Securities. 

Section 10.02. Provisions of Indenture for the Sole Benefit of Parties and
Securityholders. Nothing in this Indenture or in the Securities, expressed or implied, shall give or be construed to give to any Person other than the parties hereto and their successors and the Holders of the Securities, any legal or
equitable right, remedy or claim under this Indenture or under any covenant or provision herein contained, all such covenants and provisions being for the sole benefit of the parties hereto and their successors and of the Holders of the Securities.

 Section 10.03. Successors and Assigns of Company Bound by Indenture. All the
covenants, stipulations, promises and agreements in this Indenture contained by or on behalf of the Company shall bind its successors and assigns, whether so expressed or not. 

Section 10.04. Notices and Demands on Company, Trustee and Securityholders. Any
notice or demand which by any provision of this Indenture is required or permitted to be given or served by the Trustee or the Holders of Securities to or on the Company shall be in the English language and shall be given or served by being
deposited postage prepaid, first-class or similar class mail (except as otherwise specifically provided herein) or by facsimile addressed (until another address of the Company is filed by the Company with the Trustee) at the following address: 

Company: 
 Nomura Holdings,
Inc. 
 9-1, Nihonbashi 1-chome, Chuo-ku 
 Tokyo 103-8645 

Japan 
 Attention: Treasury and
Capital Management Department 
 Fax: +81-3-6702-7850 

Any notice, direction, request or demand by the Company or any Securityholder to or upon the Trustee shall be deemed to have been
sufficiently given or made, for all purposes, if given or made in writing in the English language to its Corporate Trust Office. 
 Where
this Indenture provides for notice to Holders of Registered Securities, such notice shall be sufficiently given (unless otherwise herein expressly provided) if in writing and mailed, first-class postage prepaid, to each Holder entitled thereto, at
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to Holders is given by mail, neither the failure to mail such notice, nor any defect in any notice so mailed, to any particular Holder shall affect the sufficiency of such notice with respect to
other Holders. Where this Indenture provides for notice in any manner, such notice may be waived in writing by the person entitled to receive such notice, either before or after the event, and such waiver shall be the equivalent of such notice.
Waivers of notice by Holders shall be filed with the Trustee, but such filing shall not be a condition precedent to the validity of any action taken in reliance upon such waiver. 

In case, by reason of the suspension of or irregularities in regular mail service, it shall be impracticable to mail notice to the Company
and Holders of Registered Securities when such notice is required to be given pursuant to any provision of this Indenture, then any manner of giving such notice as shall be reasonably satisfactory to the Trustee shall be deemed to be a sufficient
giving of such notice. 
 Any notice or demand will be deemed to have been sufficiently given or served when so sent or deposited and, if
to the Holders, when delivered in accordance with the applicable rules and procedures of the Clearing Organization. Notwithstanding anything to the contrary herein, any such notice, which are purported to be made to the beneficial owner of the
Securities through the Clearing Organization, may be delivered to the Clearing Organization in a manner the Company deems appropriate, and shall be deemed to have been delivered on the day such notice is delivered to the Clearing Organization, or if
by mail, when so sent or deposited. 
 Section 10.05. Officer’s
Certificates and Opinions of Counsel; Statements to be Contained Therein. Upon any application or demand by the Company to the Trustee to take any action under any of the provisions of this Indenture, the Company shall furnish to the
Trustee an Officer’s Certificate stating that all conditions precedent provided for in this Indenture relating to the proposed action have been complied with and an Opinion of Counsel stating that in the opinion of such counsel all such
conditions precedent have been complied with. 
 All such Officer’s Certificates and Opinions of Counsel shall be in English or
accompanied by a certified translation. 
 Each certificate or opinion provided for in this Indenture and delivered to the Trustee with
respect to compliance with a condition or covenant provided for in this Indenture shall include (a) a statement that the person making such certificate or opinion has read such covenant or condition, (b) a brief statement as to the nature
and scope of the examination or investigation upon which the statements or opinions contained in such certificate or opinion are based, (c) a statement that, in the opinion of such person, he has made such examination or investigation as is
necessary to enable him to express an informed opinion as to whether or not such covenant or condition has been complied with and (d) a statement as to whether or not, in the opinion of such person, such condition or covenant has been complied
with. 
 Any certificate, statement or opinion of an officer of the Company may be based, insofar as it relates to legal matters, upon a
certificate or opinion of or representations by counsel, unless such officer knows that the certificate or opinion or representations with respect to the matters upon which his certificate, statement or opinion may be based as aforesaid are
erroneous, or in the exercise of reasonable care should know that the same are erroneous. Any certificate, statement or opinion of counsel may be based, insofar as it relates to factual matters, information with respect to which is in the possession
of the Company, upon the certificate, statement or opinion of or representations by an officer of officers of the Company, unless such counsel knows that the certificate, statement or opinion or representations with respect to the matters upon which
his certificate, statement or opinion may be based as aforesaid are erroneous, or in the exercise of reasonable care should know that the same are erroneous. 

Any certificate, statement or opinion of an officer of the Company or of counsel may be based, insofar as it relates to accounting matters,
upon a certificate or opinion of or representations by an accountant or firm of accountants in the employ of the Company, as the case may be, unless such officer or counsel, as the case 

  
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may be, knows that the certificate or opinion or representations with respect to the accounting matters upon which his certificate, statement or opinion may be based as aforesaid are erroneous,
or in the exercise of reasonable care should know that the same are erroneous. 

Section 10.06. Conflict of any Provision of Indenture with Trust Indenture Act. If and to
the extent that any provision of this Indenture limits, qualifies or conflicts with another provision included in this Indenture by operation of Sections 310 to 317, inclusive, of the Trust Indenture Act (an “Incorporated
Provision”), such Incorporated Provision shall control. 
 Section 10.07. New York
Law to Govern. This Indenture and each Security shall be deemed to be a contract under the laws of the State of New York, and for all purposes shall be construed in accordance with the laws of such State. 

Section 10.08. Counterparts. This Indenture may be executed in any number of
counterparts, each of which shall be an original; but such counterparts shall together constitute but one and the same instrument. 
 
Section 10.09. Effect of Headings. The Article and Section headings herein and the Table of Contents are for convenience only and shall not affect the construction hereof. 

Section 10.10. Submission To Jurisdiction. To the fullest extent permitted by
applicable law, the Company irrevocably submits to the non-exclusive jurisdiction of any Federal or State court in the Borough of Manhattan in The City of New York, County and State of New York, United States
of America, in any suit or proceeding based on or arising under this Indenture and the Securities, and irrevocably agrees that all claims in respect of such suit or proceeding may be determined in any such court. The Company, to the fullest extent
permitted by applicable law, irrevocably and fully waives the defense of an inconvenient forum to the maintenance of such suit or proceeding and hereby irrevocably designates and appoints Nomura Holding America Inc., with offices currently at
Worldwide Plaza, 309 West 49th Street, New York, New York 10019-7316 (Attention: Legal Department), as its authorized agent (the “Authorized Agent”) upon whom process may be served in any such suit or proceeding. The Company
represents that it has notified the Authorized Agent of such designation and appointment and that the Authorized Agent has accepted the same. The Company hereby irrevocably authorizes and directs its Authorized Agent to accept such service. The
Company further agrees that service of process upon its Authorized Agent and written notice of said service to it mailed by first-class mail or delivered to the Company shall be deemed in every respect effective service of process upon it in any
such suit or proceeding. Nothing herein shall affect the right of any person to serve process in any other manner permitted by law. The Company agrees that a final action in any such suit or proceeding shall be conclusive and may be enforced in
other jurisdictions by suit on the judgment or in any other lawful manner. 
 The Company hereby irrevocably waives, to the extent
permitted by law, any immunity to jurisdiction to which it may otherwise be entitled (including, without limitation, immunity to pre-judgment attachment, post-judgment attachment and execution) in any legal
suit, action or proceeding against it arising out of or based on this Indenture, the Securities or the transactions contemplated hereby. 

The provisions of this Section 10.10 are intended to be effective upon the execution of this Indenture without any further action by the
Company or the Trustee and the introduction of a true copy of this Indenture into evidence shall be conclusive and final evidence as to such matters. 

Section 10.11. Non-Business Day. In any case
where the date of payment of interest, redemption or stated maturity of a Security established in accordance with Section 2.03 shall not be a Business Day at any Place of Payment with respect to Securities of that series, then (unless otherwise
specified in the Securities) payment of principal of and interest, if any, with respect to such Security need not be made at such Place of Payment on such date, but may be made on the next succeeding Business Day at such Place of Payment

  
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with the same force and effect as if made on the date of payment of interest, redemption or stated maturity of a Security established in accordance with Section 2.03, provided that no
interest shall accrue for the period from and after such date of payment of interest, redemption or stated maturity of a Security, as the case may be. 

Section 10.12. Waiver of Jury Trial. EACH PARTY HERETO HEREBY IRREVOCABLY WAIVES, TO
THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF OR RELATING TO THIS INDENTURE, THE SECURITIES OR THE TRANSACTIONS CONTEMPLATED HEREBY. 

Section 10.13. Patriot Act. The parties hereto acknowledge that, in accordance with
Section 326 of the USA Patriot Act (Title III of Pub. L. 107-56 (signed into law October 26, 2001)) (as amended, modified or supplemented from time to time, the “USA Patriot Act”),
the Trustee, like all financial institutions, is required to obtain, verify, and record information that identifies each person or legal entity that opens an account. The parties to this Indenture agree that they will provide the Trustee with such
information as the Trustee may request in order for the Trustee to satisfy the requirements of the USA Patriot Act. 
 ARTICLE 11 

REDEMPTION AND REPURCHASE OF SECURITIES 

Section 11.01. Applicability of Article. The provisions of this Article shall be
applicable to the Securities of any series which are redeemable before their maturity except as otherwise specified as contemplated by Section 2.03 for Securities of such series. 

Section 11.02. Optional Redemption Due to Changes in Tax Treatment. Unless otherwise
specified as contemplated by Section 2.03 for a particular series of Securities, the Company may, subject to prior confirmation of the FSA (if such confirmation is required under the Financial Instruments and Exchange Act of Japan (Act
No. 25 of 1948, as amended) (the “Financial Instruments and Exchange Act”) or any other applicable laws and regulations then in effect), on giving at least 45 days’, but not more than 60 days’, notice to the Trustee
(which notice shall be irrevocable), redeem all, but not less than all, of the Securities of such series then outstanding at a redemption price equal to the principal amount of the Securities (or if the Securities are Original Issue Discount
Securities, such amount as determined as contemplated by Section 2.03) plus any accrued but unpaid interest through but not including the date fixed for redemption and any related Additional Amounts, in each case with respect to the Securities
being redeemed, in the event that the Company determines that, as a result of any change in or amendment to the laws or treaties (or any regulations or rulings promulgated thereunder) of Japan or any political subdivision or authority thereof or
therein having power to tax, or any change in official position regarding the application or interpretation of such laws, treaties, regulations or rulings (including a holding, judgment or order by a court of competent jurisdiction), which change or
amendment becomes effective on or after the date of the final offering document for the relevant series of Securities, the Company has or will become obligated to pay Additional Amounts with respect to the Securities of such series (and such
obligation cannot be avoided through the taking of reasonable measures available to the Company).. The Trustee will notify the Holders at least 30 days prior to the date fixed for any such redemption. Prior to the Company’s giving of any notice
of redemption for tax reasons as described in this paragraph, the Company shall deliver to the Trustee (i) an Officer’s Certificate stating that the Company is entitled to effect such redemption and setting forth a statement of facts
showing that the conditions precedent to the right of the Company to so redeem have occurred and (ii) an Opinion of Counsel to such effect based on such statement of facts; provided that no such notice of redemption shall be given earlier than
60 days prior to the earliest date on which the Company would be obligated to pay such Additional Amounts if a payment in respect of the Securities were then due. 

Section 11.03. Notice of Redemption. Notice of redemption to the Holders of
Securities of any series to be redeemed as a whole or in part at the option of the Company shall be given by mailing notice of such redemption by first-class mail, postage prepaid, at not less than 30 days and not more than 60 days prior to the

  
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date fixed for redemption to such Holders of Securities of such series at their last addresses as they shall appear upon the Register. Any notice which is mailed in the manner herein provided
shall be conclusively presumed to have been duly given, whether or not the Holder receives the notice. Failure to give notice by mail, or any defect in the notice to the Holder of any Security of a series designated for redemption as a whole or in
part shall not affect the validity of the proceedings for the redemption of any other Security of such series. 
 The notice of redemption
to each such Holder shall specify the principal amount and CUSIP or ISIN number (if any) of each Security of such series held by such Holder to be redeemed, the date fixed for redemption, the redemption price, the place or places of payment, that
payment will be made upon presentation and surrender of such Securities, that interest accrued to the date fixed for redemption will be paid as specified in such notice and that on and after said date interest thereon or on the portions thereof to
be redeemed will cease to accrue. In case any Security of a series is to be redeemed in part only the notice of redemption shall state the portion of the principal amount thereof to be redeemed and shall state that on and after the date fixed for
redemption, upon surrender of such Security, a new Security or Securities of such series in principal amount equal to the unredeemed portion thereof will be issued. 

The notice of redemption of Securities of any series to be redeemed at the option of the Company shall be given by the Company or, at the
Company’s request, by the Trustee in the name and at the expense of the Company. 
 On or before the redemption date specified in the
notice of redemption given as provided in this Section (and in any event no later than 10:00 a.m., New York time, on the due date for payment), the Company will deposit with the Trustee or with one or more Paying Agents (or, if the Company is acting
as its own Paying Agent, set aside, segregate and hold in trust as provided in Section 3.04) an amount of money or other property sufficient to redeem on the redemption date all the Securities of such series so called for redemption at the
appropriate redemption price, together with accrued interest to the date fixed for redemption and any Additional Amounts. 
 
Section 11.04. Payment of Securities Called for Redemption. If notice of redemption has been given as above provided, the Securities or portions of Securities specified in such notice shall become due and payable on the
date and at the place stated in such notice at the applicable redemption price, together with interest accrued to the date fixed for redemption, and on and after said date (unless the Company shall default in the payment of such Securities at the
redemption price, together with interest accrued to said date) interest on the Securities or portions of Securities so called for redemption shall cease to accrue and, except as provided in Section 5.05 and Section 9.03, such Securities
shall cease from and after the date fixed for redemption to be entitled to any benefit or security under this Indenture, and the Holders thereof shall have no right in respect of such Securities except the right to receive the redemption price
thereof and unpaid interest to the date fixed for redemption. On presentation and surrender of such Securities at a place of payment specified in said notice, said Securities or the specified portions thereof shall be paid and redeemed by the
Company at the applicable redemption price, together with interest accrued thereon to the date fixed for redemption; provided that any semiannual payment of interest becoming due on the date fixed for redemption shall be payable to the Holders of
such Securities registered as such on the relevant record date subject to the terms and provisions of Sections 2.03 and 2.04 hereof. 
 If
any Security called for redemption shall not be so paid upon surrender thereof for redemption, the principal shall, until paid or duly provided for, bear interest from the date fixed for redemption at the rate of interest or Yield to Maturity (in
the case of an Original Issue Discount Security) borne by such Security. 
 Upon presentation of any Security redeemed in part only, the
Company shall execute and the Trustee shall authenticate and deliver to or on the order of the Holder thereof, at the expense of the Company, a new Security or Securities of such series, of authorized denominations, in principal amount equal to the
unredeemed portion of the Security so presented. 

  
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 Section 11.05. Exclusion of Certain Securities
from Eligibility for Selection for Redemption. Securities shall be excluded from eligibility for selection for redemption if they are identified by registration and certificate number in a written statement signed by an authorized officer
of the Company and delivered to the Trustee at least 40 days prior to the last date on which notice of redemption may be given as being owned of record and beneficially by, and not pledged or hypothecated by either (a) the Company or
(b) an entity specifically identified in such written statement as directly or indirectly controlling or controlled by or under direct or indirect common control with the Company. 

Section 11.06. Repurchase of Securities. The Company or any subsidiary of the Company
may, at any time, subject to prior confirmation of the FSA (if such confirmation is required under the Financial Instruments and Exchange Act or any other applicable laws and regulations then in effect), purchase any or all of the Securities in the
open market or otherwise at any price in accordance with any applicable law or regulation. Subject to applicable law, neither the Company nor any subsidiary of the Company shall have any obligation to purchase or offer to purchase any Securities
held by any Holder as a result of its purchase or offer to purchase Securities held by any other Holder in the open market or otherwise. Any such Securities purchased by the Company or any subsidiary of the Company may, at the discretion of the
Company or the relevant subsidiary, as the case may be, be held or resold or surrendered to the Trustee for cancellation by the Company or any such subsidiary, as the case may be. The Securities so purchased, while held by or on behalf of the
Company or any such subsidiary, as the case may be, shall not entitle the holder to vote at any meetings of the holders of the relevant series of Securities and shall not be deemed to be Outstanding for the purposes of calculating quorums at
meetings of the Holders of such series of Securities or for the purposes of Article 4. The provisions of this Section are subject to Section 2.03. 

[Signature pages follow] 

  
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 IN WITNESS WHEREOF, the parties hereto have caused this Indenture to be duly executed as of
the date first written above. 
  

			
	 NOMURA HOLDINGS, INC.

		
	 By:
	 	 
		 	 Name:

		 	Title:

 [Signatures continue on next page] 

 
  
  

[Signature page to Senior Debt Indenture] 

Table of Contents

 
			
	 CITIBANK, N.A.

as Trustee

		
	 By:
	 	 
		 	Name:
		 	 Title:

 [End of Signatures] 
  

 
  

[Signature page to Senior Debt Indenture] 

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 EXHIBIT A 

FORM OF OFFICER’S CERTIFICATE OF NOMURA HOLDINGS, INC. 

PURSUANT TO SECTION 3.06 
 Date:
[            ] 
 Pursuant to Section 3.06 of the Indenture dated as of
[            ] (the “Indenture”), between Nomura Holdings, Inc. (the “Company”) and Citibank, N.A., as trustee, relating to the issuance of
$[            ] aggregate principal amount of [[    ]%] senior [floating rate] notes due 20[    ] (the “Securities”), the undersigned does
hereby certify, in [his/her] capacity as a Responsible Officer of the Company (as defined in the Indenture), that: 
 As of the date hereof, the Company [is
in compliance with all conditions and covenants on its part under the Indenture.][is not in compliance with all conditions and covenants under the Indenture, details of each such default and the nature and status thereof specified below:
[            ]] 
 [Signature page follows] 

  
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 IN WITNESS WHEREOF, the undersigned has executed this compliance certificate as of the date set forth above.

  

			
	 By:
	 	 
		 	Name:
		 	Title:
		
	 By:
	 	  

		 	Name:
		 	Title:

  
 A-2

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