Document:

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                                                                    EXHIBIT 10.7

                                    SUBLEASE

         THIS SUBLEASE ("Sublease"), dated August 3, 1999 for reference purposes
only, is entered into by and between REGEN BIOLOGICS, INC., a Delaware
corporation ("Regen") and GENITOPE CORPORATION a Delaware corporation
("Subtenant").

                                    RECITALS

         A.       Regen leases certain premises consisting of approximately
15,021 square feet, located at "Building 12" of Seaport Center, 545 Penobscot
Drive, Redwood City, California, 94063 pursuant to that certain Lease dated
April 10, 1996, between Metropolitan Life Insurance Company, as landlord (the
"Master Landlord") and Regen, as tenant (the "Master Lease"), as more
particularly described therein (the "Master Premises"). Capitalized terms used
but not defined herein have the same meanings as they have in the Master Lease.
A copy of the Master Lease is attached hereto as EXHIBIT A.

         B.       Regen desires to sublease a portion of the Premises to
Subtenant, and Subtenant desires to sublease a portion of the Premises from
Regen on the terms and provisions hereof.

         NOW, THEREFORE, in consideration of the mutual covenants and conditions
contained herein, Regen and Subtenant covenant and agree as follows:

                                    AGREEMENT

         1.       PREMISES. On and subject to the terms and conditions below,
Regen hereby leases to Subtenant, and Subtenant hereby leases from Regen a
portion of the Master Premises consisting of 6,775 rentable square feet, and as
more fully described in EXHIBIT B (the "Premises")

         2.       TERM. This Sublease shall commence on the day following the
last to occur of (i) Master Landlord's consent to this Sublease in a form
reasonably acceptable to Regen and Subtenant and (ii) Regen's delivery of
possession of the Premises to Subtenant, separately demised and with all
improvements contemplated by Section 8 hereof completed, excepting only minor
"punch-list" items that can be completed without material interference to
Subtenant (the "Commencement Date") and shall expire June 30, 2000, unless
sooner terminated pursuant to any provision hereof. In no event shall the term
of this Sublease, as may be extended, extend beyond the term of the Master
Lease.

         3.       POSSESSION. If for any reason Regen cannot deliver possession
of the Premises to Subtenant by the Commencement Date, Regen shall not be
subject to any liability therefor, nor shall such failure affect the validity of
this Sublease or the obligations of Subtenant hereunder or extend the term
hereof, provided that no rent shall be due hereunder until possession of the
Premises has been delivered to Subtenant. If Regen has not delivered the
Premises to Subtenant on or before August 15, 1999, then Subtenant shall have
the right until such delivery to cancel this Sublease, and upon such
cancellation, Regen shall return all sums theretofore deposited by Subtenant
with Regen, and neither party shall have any further liability to the other.

                                       1.

<PAGE>

         4.       RENT.

                  (a)      Commencing on the Commencement Date and continuing
throughout the term of this Sublease, Subtenant shall pay monthly rent ("Rent")
to Regen in the amount of Eighteen Thousand Three Hundred Fifteen Dollars and
25/100 ($18,315.25), without increase during the initial term. The Rent payable
hereunder is a full-service rent and inclusive of real property taxes, Operating
Expenses (as defined in the Master Lease), and a commercially reasonable amount
(considering Subtenant's permitted use) of janitorial, utilities, and garbage.

                  (b)      If the Commencement Date does not fall on the first
day of a calendar month, Rent for the second month shall be prorated on a daily
basis based upon a calendar month. Rent shall be payable to Regen in lawful
money of the United States, in advance, without prior notice, demand, or offset,
on or before the first day of each calendar month during the term hereof. All
Rent shall be paid to Regen at the address specified for notices to Regen in
SECTION 18, below.

                  (c)      Upon commencement of this Sublease, Subtenant shall
deliver to Regen the sum of Eighteen Thousand Three Hundred Fifteen Dollars and
25/100 ($18,315.25), representing the first month's Base Rent.

                  (d)      In the event of any casualty or condemnation
affecting the Premises, Rent payable by Subtenant shall be abated hereunder, but
only to the extent that Rent under the Master Lease is abated as to that portion
of the Master Premises which constitute the Premises under this Sublease.
Subtenant waives any right to terminate this Sublease in connection with such
casualty or condemnation except to the extent the Master Lease is also
terminated as to the Premises or any portion thereof.

         5.       SECURITY DEPOSIT. Upon execution of this Sublease, Subtenant
shall deposit with Regen the sum of Eighteen Thousand Three Hundred Fifteen
Dollars and 25/100 ($18,315.25) as a security deposit ("Security Deposit"). If
Subtenant falls to pay Rent or other charges when due under this Sublease, or
fails to perform any of its other obligations hereunder, Regen may use or apply
all or any portion of the Security Deposit for the payment of any Rent or other
amount then due hereunder and unpaid, for the payment of any other sum for which
Regen may become obligated by reason of Subtenant's default or breach, or for
any loss or damage sustained by Regen as a result of Subtenant's default or
breach. If Regen so uses any portion of the Security Deposit, Subtenant shall
restore the Security Deposit to the full amount originally deposited within ten
(10) days after Regen's written demand. Regen shall keep the Security Deposit in
an account separate from its general accounts, but shall have no obligation or
liability for payment of interest on the Security Deposit. The Security Deposit,
or so much thereof as had not theretofore been applied by Regen, shall be
returned to Subtenant within thirty (30) days of the expiration or earlier
termination of this Sublease, provided Subtenant has vacated the Premises.

         6.       ASSIGNMENT AND SUBLETTING.

                  (a)      Subtenant may not assign, sublet, or transfer the
Premises, in whole or in part, or permit the use or occupancy of the Premises by
anyone other than Subtenant (collectively referred to herein as a "Transfer"),
unless Subtenant has obtained Regen's consent thereto (which

                                       2.

<PAGE>

shall not be unreasonably withheld) and the consent of Master Landlord.
Regardless of Regen's consent, no Transfer shall release Subtenant of its
obligations hereunder.

                  (b)      Notwithstanding the foregoing, subject to any rights
of the Master Landlord, provided Subtenant has not been in monetary default or
any other material default beyond any applicable cure periods, Regen hereby
consents to Subtenant's subleasing to Genelabs Technologies, Inc. any time
during the term of this Sublease or any extension thereof.

                  (c)      Any consideration payable to Subtenant pursuant to
any Transfer permitted by this paragraph which is in excess of the Rent payable
to Regen pursuant hereto shall be divided equally between Regen and Subtenant.
For purposes of this section 7, the term "consideration" shall mean all
consideration to be paid by the Transferee to Tenant or to any other party on
Tenant's behalf or for Tenant's benefit as consideration for such assignment,
without deduction for any commissions paid by Tenant or any other costs or
expenses (including, without limitation, capital improvements, building
upgrades, permit fees, attorneys' fees, and other consultants' fees) incurred by
Tenant in connection with such Transfer.

         7.       CONDITION OF PREMISES. Subtenant has used due diligence in
inspecting the Premises and agrees to accept the Premises in "as-is" condition
and with all faults as of the date of Subtenant's execution of this Sublease,
without any representation or warranty of any kind or nature whatsoever, or any
obligation on the part of Regen to modify, improve or otherwise prepare the
Premises for Subtenant's occupancy, except as expressly provided in Section 8
below. By entry hereunder, Subtenant accepts the Premises in their present
condition and without representation or warranty of any kind by Regen. Subtenant
hereby expressly waives the provisions of subsection 1 of Section 1932 and
Sections 1941 and 1942 of the California Civil Code and all rights to make
repairs at the expense of Regen as provided in Section 1942 of said Civil Code.

         8.       TENANT IMPROVEMENTS.

                  (a)      DEMISING WALLS: Regen shall cause to be installed two
(2), demising locked doors and walls to separate the Premises from the Master
Premises, framed for the installation of doors as provided in subsection C
below, and the costs thereof shall be shared equally by Regen and Subtenant.

                  (b)      FLOOR COVERINGS AND HVAC: In lieu of Regen providing
floor coverings in the R&D room in the Premises, Regen shall provide Subtenant
with a rent credit in the amount of $3,000 to be applied against the first
month's Rent. Regen shall, at its sole cost and expense, provide the R&D room in
the Premises with HVAC service, and shall maintain such HVAC service in good
working order and repair throughout the term of this Sublease and any extensions
thereof.

                  (c)      DOORS:

                           (i)      Regen shall cause to be installed three (3)
locked doors. Such doors shall be located as follows: one in between the
Premises and the Lobby, one in between the Premises and the bathrooms, and one
in between the Premises and the warehouse. Such work shall be completed by Regen
in compliance with this Sublease and all applicable laws and codes.

                                       3.

<PAGE>

                           (ii)     Regen shall cause to be installed at its
sole cost and expense one door in between the Master Premises and the Lobby, and
Regen shall cause three existing doors to be modified for panic hardware.
Subtenant shall cause to be installed one door between warehouse and their
current premises at subtenants sole cost.

                  (d)      COMMON AREAS: Regen shall not have the right,
separate from the Master Landlord, to alter common areas as between Subtenant
and Regen without the consent of Subtenant (which consent shall not be
unreasonably withheld or delayed).

         9.       USE. Subtenant may use the Premises only for the purposes as
allowed in the Master Lease, and for no other purpose. Subtenant shall promptly
comply with all applicable statutes, ordinances, rules, regulations, orders,
restrictions of record, and requirements in effect during the term of this
Sublease governing, affecting and regulating the Premises, including but not
limited to the use thereof. Subtenant shall not use or permit the use of the
Premises in a manner that will create waste or a nuisance, interfere with or
disturb other tenants in the Building or violate the provisions of the Master
Lease. Regen warrants that at the time of execution of this Sublease that it has
not received any notice of violation of any statute, ordinance, rule,
regulation, order, restriction of record, or requirements in effect affecting
and regulating the Premises as used by Regen. Notwithstanding the foregoing,
Subtenant shall only be responsible for compliance with the Americans with
Disabilities Act or any other code or legal requirement if such compliance is
triggered by Subtenant's extraordinary type of use of the Premises or any
extraordinary type of work (including any alterations) performed by, or at the
direction of, Subtenant (excluding the Tenant improvements to be completed by
Subtenant pursuant to Section 8 hereof).

         10.      PARKING. Subtenant shall have a pro rata share of such parking
rights as Regen may have in connection with the Master Premises pursuant to the
Master Lease. As of the execution hereof, Subtenant's pro rata share is fifteen
(15) parking spaces.

         11.      SIGNAGE. Subtenant shall have a pro rata share of such signage
rights as Regen may have in connection with the Master Premises pursuant to the
Master Lease.

         12.      PHONE/DATA ROOM. Regen shall permit Subtenant use of Regen's
phone system and data room for the sole purpose of installation and use of
telecommunications and data delivery systems, provided such use does not
interfere with the proper use of Regen's phone systems and data communications.
Subtenant shall indemnify and hold Regen harmless against any costs incurred by
Regen that are due to Subtenant's use of such equipment.

         13.      RIGHTS OF FIRST OFFER. In the event that Regen elects to
sublease a portion of the Master Premises (other than the Premises or any
additional warehouse space) to the general public during the term of this
Sublease, Regen shall notify Subtenant in writing of such availability and the
terms and conditions on which Regen will lease the space. Subtenant shall have
seven (7) days in which to notify Regen in writing of Subtenant's binding
decision to sublease the space under the terms and conditions contained in
Regen's notice and otherwise on the terms and conditions as contained herein. In
the event that Subtenant does not give such written notice to Regen, Subtenant
shall have no further right to lease the space and Regen shall

                                       4.

<PAGE>

be free to lease the space to any other person or entity on any terms and
conditions as Regen in its sole discretion deems appropriate.

         14.      WAREHOUSE SPACE.

                  (a)      RIGHTS OF FIRST OFFER. In the event that Regen elects
to sublease a portion of the warehouse to the general public during the term of
this Sublease, Regen shall notify Subtenant in writing of such availability and
the terms and conditions on which Regen will lease the space, provided however,
that the rent for such warehouse space shall not exceed $1.25/foot during the
initial term hereof. Subtenant shall have seven (7) days in which to notify
Regen in writing of Subtenant's binding decision to sublease the space under the
terms and conditions contained in Regen's notice, and otherwise on the terms and
conditions as contained herein. In the event that Subtenant does not give such
written notice to Regen, Subtenant shall have no further right to lease the
space and Regen shall be free to lease the space to any other person or entity
on any terms and conditions as Regen in its sole discretion deems appropriate.

                  (b)      OPTION. Provided Subtenant has not been in default
under this Sublease of a monetary obligation, for a period in excess of three
business days following Regen's written notice of default under this Sublease
and is not otherwise in default of a non-monetary obligation, Subtenant shall
have an option to lease the warehouse space at $1.25/foot for the balance of the
term of this Sublease. Such option must be exercised, if at all, in writing
within the first sixty (60) days term of this Sublease.

         15.      INCORPORATION OF MASTER LEASE.

                  (a)      All of the terms and provisions of the Master Lease,
except as provided in subsection (b) below, are incorporated into and made a
part of this Sublease and the rights and obligations of the parties under the
Master Lease are hereby imposed upon the parties hereto with respect to the
Premises, Regen being substituted for the "Lessor" in the Master Lease, and
Subtenant being substituted for the "Lessee" in the Master Lease. It is further
understood that where reference is made in the Master Lease to the "Premises,"
the same shall mean the Premises as defined herein; where reference is made to
the "Commencement Date," the same shall mean the Commencement Date as defined
herein; and where reference is made to the "Lease," the same shall mean this
Sublease.

                  (b)      The following sections of the Master Lease are not
incorporated herein: Basic Lease Provisions (except 1. Premises Location and 13.
Sole Permitted Use); Paragraphs: 1, 2, 3, 4, 5, 6(a), 7(a), the last sentence of
7(b)(3), 13, 14, 18, 31(b), the first sentence of 31(c), 34, 45(b), 46, and 47;
Construction Addendum, Exhibits: B, C, D, E, and F.

                  (c)      Subtenant hereby assumes and agrees to perform for
Regen's benefit, during the term of this Sublease, all of Regen's obligations
with respect to the Premises under the Master Lease, except as otherwise
provided herein. Subtenant shall not commit or permit to be committed any act or
omission which violates any term or condition of the Master Lease. Except as
otherwise provided herein, this Sublease shall be subject and subordinate to all
of the terms of the Master Lease.

                                       5.

<PAGE>

         16.      INSURANCE. Subtenant shall be responsible for compliance with
the insurance provisions of the Master Lease. Such insurance shall insure the
performance by Subtenant of its indemnification obligations hereunder and shall
name Master Landlord and Regen as additional insureds. All insurance required
under this Sublease shall contain an endorsement requiring thirty (30) days
written notice from the insurance company to Subtenant and Regen before
cancellation or change in the coverage, insureds or amount of any policy.
Subtenant shall provide Regen with certificates of insurance evidencing such
coverage prior to the commencement of this Sublease.

         17.      DEFAULT. In addition to defaults contained in the Master
Lease, failure of Subtenant to make any payment of Rent when due hereunder shall
constitute an event of default hereunder.

         18.      NOTICES. The addresses specified in the Master Lease for
receipt of notices to each of the parties are deleted and replaced with the
following:

                    TO REGEN AT:          REGEN BIOLOGICS, INC.
                                          545 Penobscot Drive
                                          Redwood City, CA 94063
                                          Attn: V/P Manufacturing and Operations

                    WITH COPY TO:         METROPOLITAN LIFE INSURANCE COMPANY
                                          101 Lincoln Center Drive
                                          Foster City, CA 94404-1167
                                          Attn: Property Manager

                    TO SUBTENANT AT:      GENITOPE CORPORATION
                                          525 Penobscot Drive
                                          Redwood City, CA 94063
                                          Attn: Director of Operations

                                          With copy to:
                                          R. Kingsbury Lane
                                          388 17th Street, Suite 250
                                          Oakland, CA 94612-3335
                                          Attn: Robert Lane, Esq.

         19.      OPTIONS TO EXTEND.

                  (a)      Provided Subtenant has not been in default under this
Sublease of a monetary obligation, for a period in excess of three business days
following Regen's written notice of default under this Sublease and is not
otherwise in default of a non-monetary obligation:

                           (i)      Subtenant shall have an option to be
exercised within the first six months of the term of this Sublease (the "First
Option") to extend the term of this Sublease to be co-terminus with Subtenant's
lease of the space adjacent to the Premises (the "Genelabs Space").

                                       6.

<PAGE>

The First Option must be exercised, if at all, by written notice to Regen during
the first 6 months of the term.

                           (ii)     If Regen extends the term of the Master
Lease, then Subtenant shall have to option to extend this Sublease to be
coterminous with the Master Lease as extended (the "Second Option"). The Second
Option must be exercised, if at all, by written notice to Regen within seven
days following Regen's notice to Subtenant that the Master Lease has been so
extended.

                  (b)      Notwithstanding anything in this Sublease to the
contrary, in no event shall the term of this Sublease extend beyond the term of
the Master Lease. All of the terms and conditions of this Sublease shall
continue to apply during the term of any such Option, except that Base Rent
shall be increased by a factor of three percent (3%) as of July 1, 2000 and on
each annual anniversary thereafter.

         20.      REGEN'S OBLIGATIONS.

                  (a)      To the extent that the provision of any services or
the performance of any maintenance or any other act respecting the Premises or
Building is the responsibility of Master Landlord (collectively "Master Landlord
Obligations"), upon Subtenant's request, Regen shall make reasonable efforts to
cause Master Landlord to perform such Master Landlord Obligations, provided,
however, that in no event shall Regen be liable to Subtenant for any liability,
loss or damage whatsoever in the event that Master Landlord should fail to
perform the same, nor shall Subtenant be entitled to withhold the payment of
Rent or terminate this Sublease. Such reasonable efforts shall include, without
limitation, upon Subtenant's request, (a) immediately notifying Master Landlord
of its non-performance under the Master Lease and requesting that Master
Landlord perform its obligations under the Master Lease and/or (b) assigning
Regen's rights under the Master Lease to Subtenant to the extent necessary to
permit Subtenant to institute legal proceedings against Master Landlord to
obtain the performance of Master Landlord's obligations under the Master Lease;
provided, however, that if Subtenant commences a lawsuit or other action,
Subtenant shall pay all costs and expenses incurred in connection therewith, and
Subtenant shall indemnify Regen against, and hold Regen harmless from, all costs
and expenses incurred by Regen in connection therewith. It is expressly
understood that the services and repairs which are incorporated herein by
reference, including but not limited to the maintenance of exterior walls,
structural portions of the roof, foundations, walls and floors, will in fact be
furnished by Master Landlord and not by Regen, except to the extent otherwise
provided in the Master Lease. In addition, Regen shall not be liable for any
maintenance, restoration (following casualty or destruction) or repairs in or to
the Building or Premises, other than its obligation hereunder to use reasonable
efforts to cause Master Landlord to perform its obligations under the Master
Lease. With respect to any maintenance or repair to be performed by Master
Landlord respecting the Premises, the parties expressly agree that Subtenant
shall have the right to contact Master Landlord directly to cause it to so
perform.

         21.      EARLY TERMINATION OF SUBLEASE. If, without the fault of Regen,
the Master Lease should terminate prior to the expiration of this Sublease,
Regen shall have no liability to Subtenant on account of such termination. To
the extent that the Master Lease grants Regen any discretionary right to
terminate the Master Lease, whether due to casualty, condemnation, or

                                       7.

<PAGE>

otherwise, Regen shall be entitled to exercise or not exercise such right in its
complete and absolute discretion and shall use its best efforts to provide
reasonable notice to Subtenant of such exercise.

         22.      NOTIFICATION OF MASTER LANDLORD AND REGEN. If Subtenant is
required to notify Regen pursuant to the terms of this Sublease, then,
notwithstanding anything to the contrary herein, Subtenant shall also notify
Master Landlord concurrently.

         23.      CONSENT OF MASTER LANDLORD AND REGEN. If Subtenant desires to
take any action which requires the consent or approval of Master Landlord
pursuant to the terms of the Master Lease, prior to taking such action,
including, without limitation, making any tenant improvements, then,
notwithstanding anything to the contrary herein, (a) Regen shall have the same
rights of approval or disapproval as Master Landlord has under the Master Lease,
and (b) Subtenant shall not take any such action until it obtains the consent of
Regen and Master Landlord, as may be required under this Sublease or the Master
Lease. This Sublease shall not be effective unless and until any required
written consent of the Master Landlord shall have been obtained.

         24.      BROKERS. Each party hereto represents and warrants that it has
dealt with no broker in connection with this Sublease and the transactions
contemplated herein, except for Cornish & Carey Commercial. Each party shall
indemnify, protect, defend and hold the other party harmless from all costs and
expenses (including reasonable attorneys' fees) arising from or relating to a
breach of the foregoing representation and warranty.

         25.      SURRENDER OF PREMISES. Upon the expiration or earlier
termination of this Sublease, Subtenant shall, at the request of Regen, remove
the tenant improvements and shall otherwise surrender the Premises in the same
condition as they were in on the Commencement Date, except for ordinary wear and
tear. Notwithstanding the foregoing, Regen shall only request the removal of
such improvements (i) if the Master Landlord has requested from Regen their
removal, or (ii) if Regen is otherwise obligated to remove such improvements.

         26.      NO THIRD PARTY RIGHTS. The benefit of the provisions of this
Sublease is expressly limited to Regen and Subtenant and their respective
permitted successors and assigns. Under no circumstances will any third party be
construed to have any rights as a third party beneficiary with respect to any of
said provisions.

         27.      COUNTERPARTS. This Sublease may be signed in two or more
counterparts, each of which shall be deemed an original and all of which shall
constitute one agreement.

         28.      CONFLICT. In the event of any conflict between the Master
Lease and this Sublease, as between Regen and Subtenant, the terms and
conditions of this Sublease shall control.

         29.      AFFECTED RIGHTS/OBLIGATIONS. Except as otherwise provided
herein, whether involving rights and/or obligations under the Master Lease,
where the Premises are not affected, directly or indirectly, Subtenant shall
have no rights to enforce nor obligations or duties to perform, whichever may be
applicable.

                                       8.

<PAGE>

         IN WITNESS WHEREOF, the parties have executed this Sublease as of the
date first written above.

REGEN BIOLOGICS, INC.                             GENITOPE CORPORATION

By:/s/ Philip A. Timenaro                         By:/s/ Milton B. McColl
   ---------------------------------------           ---------------------------
               (signature)                                       (signature)

By: Philip A. Timenaro                            By: Milton B. McColl
    --------------------------------------            --------------------------
               (printed name)                                    (printed name)

Title: Director of Office Operations              Title: Chief Executive Officer

Date:8/17/99                                      Date:_________________________

                                       9.

<PAGE>

                                    EXHIBIT A

                                  MASTER LEASE

                                See Exhibit 10.10

                                       1

<PAGE>

                                    EXHIBIT B

                                   Floor plan

                                       2<PAGE>
!
                                                                    EXHIBIT 10.8

                     SECOND AMENDMENT TO SUBLEASE AGREEMENT

         THIS SECOND AMENDMENT TO SUBLEASE AGREEMENT ("Amendment") is entered
into, and dated for reference purposes, as of October 1, 2000 by and between
REGEN BIOLOGICS, INC. (hereinafter referred to as "Sublessor") and GENITOPE
CORPORATION (hereinafter referred to as "Sublessee"), and is a second amendment
to the Sublease Agreement between the Sublessor and Sublessee dated as of August
3, 1999 (the "Sublease"), with reference to the following facts:

                                    RECITALS

         A.       Sublessor and Sublessee entered into the Sublease for
approximately 6,775 square feet of office and R&D space expiring on June 30,
2000.

         B.       On March 13, 2000 Genitope Corporation notified Regen
Biologics, Inc. of the exercise of its option under Section 19(a)(i) of the
Sublease between Genitope Corporation and Regen Biologics, Inc. dated August 3,
1999, to extend the term of said Sublease until December 31, 2000 which Regen
acknowledges is a valid extension duly approved by the Master Lessor.

         D.       Sublessor and Sublessee now desire to modify and amend the
Sublease to provide for an extension of the term, and to include the additional
sublease of the unimproved warehouse space as follows:

         Now Therefore, in consideration of the foregoing, and for other good
and valuable consideration, Sublessor and Sublessee agree that the Sublease
shall be and is hereby amended as of January 1, 2001 as follows:

         1.       SUBLEASED SPACE. In addition to the current subleased
premises, Sublessor hereby lease to Sublessee and Sublessee agrees to lease from
Sublessor, effective January 1, 2001, that certain unimproved warehouse space of
approximately one thousand four hundred eighty-three (1483) square feet as shown
on Exhibit "A" attached hereto and incorporated herein by this reference. Thus
the total space which shall be exclusively Sublesse's shall be approximately
seven thousand six hundred fifty-five (7655) square feet and the common space
shared by Sublessee and Sublessor (including entry, toilet) shall be twelve
hundred six (1206) square feet, for which Sublessee shall be responsible for the
payment of rent based upon fifty percent (50%) of said common space or six
hundred three (603) square feet. The exclusive and non-exclusive space are as
follows:

<TABLE>
<S>                                        <C>
Office                                     3279 sq. ft.
R&D                                        1666 sq. ft.
Access Corridor                            1227 sq. ft.
Warehouse (Added)                          1483 sq. ft.
                                           ------------
                                           7655 sq. ft.

Shared entry, toilet and Common Space,
1206 sq. ft. @ 50%                          603 sq. ft.
                                           ------------
TOTAL                                      8258 sq. ft.
</TABLE>

         The existing premises and the additional warehouse space are shown in
Exhibit A.

                                       1.

<PAGE>

         2.       EXTENSION OF TERM. The term of the Sublease is hereby amended
to extend the termination date of the Sublease to June 1, 2003, unless sooner
terminated pursuant to the Sublease or the Master Lease:

         3.       RENT. The monthly rent of $18,864.71 shall be applicable until
4/1/2001 at which time the monthly rent of $41,290.00 will be due Sublessor for
the period from April 1, 2001 to the expiration of the Sublease on June 1, 2003,
unless otherwise agreed to by the parties in writing and subject to the 3
percent increase, on July 1, 2001 and July 1, 2001, provided for in the
sublease. Upon consent being obtained from the Master Lessor, Sublessor shall
increase the security deposit of $41,290.00, and increase of $22,974.75.
Genitope will also pay a pro-rata share of any expense increases based upon the
ratio of Genitope square feet to total, which will be based on a documented year
to comparison of this increased amount, provided that the monthly combined
sublease rate and pro-rata share of expenses shall not exceed a total of $6.00
per square foot.

         4.       DEFINITIONS; OTHER TERMS. Unless otherwise set forth in this
Amendment, all capitalized terms shall have the meanings set forth in the
Sublease. All portion of this amendment are contractual in nature. Except as
otherwise set forth herein, all other terms and conditions of the Sublease and
Master Lease will remain the same.

         5.       APPROVAL OF IMPROVEMENTS. Subject to the written approval of
the Master Lessor, METROPOLITAN LIFE INSURANCE COMPANY, Sublessor does hereby
approve of the plans and specifications for the improvements ("Improvements")
contemplated by the Sublease as reflected in Exhibit "B" attached hereto and
incorporated herein by this reference, which improvements shall comply with the
insurance provisions of the Master Lessor and shall be constructed in a good
workmanlike manner consistent with any standards set forth in the Master Lease.
The Sublessee shall be solely responsible for any and all costs associated with
the preparation and installation of said Improvements and, if and where said
Improvements are fixtures, shall maintain said Improvements, subject to normal
wear and tear. The parties understand and agree that without Master Lessor
approval of the Improvements this Second Amendment to Sublease Agreement shall
be null and void.

         6.       MASTER LESSOR APPROVAL. This Amendment is subject to the
written approval by METROPOLITAN LIFE INSURANCE COMPANY (Master Lessor).

         7.       Sublessee warrants that there are no brokerage fees payable
regarding this transaction.

         8.       OPTION TO EXTEND. Any and all reference to "Sublease" in
paragraph 19(a)(ii) of that certain Sublease first dated August 3, 1999 shall
include the First Amendment to Sublease and the Second Amendment to Sublease
Agreement.

         9.       The undersigned warrants that they have been authorized and
directed to execute this Amendment on behalf of their respective entities.

                                       2.

<PAGE>

         IN WITNESS WHEREOF, the parties hereto have executed this Amendment as
of the date first set forth above.

SUBLESSEE                                       GENITOPE CORPORATION

                                                By: /s/ Dan W. Denney Jr.
                                                    ----------------------------

                                                Print Name: Dan W. Denney, Jr.

                                                Its: Chairman and CEO
                                                    ----------------------------
                                                                  (Print Title)

SUBLESSOR                                       REGEN BIOLOGICS, INC.

                                                By: /s/ Geralde Bisbee, Jr.
                                                    ----------------------------

                                                Print Name: Geralde Bisbee, Jr.

                                                Its: Chairman and CEO
                                                    ----------------------------
                                                           (Print Title)

                                       3.

<PAGE>

                                    EXHIBIT A

                                   Floor plan

                                       4.

<PAGE>

                                    EXHIBIT B

                           Description of improvements

                                       5.

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