Document:

CONFIDENTIAL TREATMENT REQUESTED

UNDER 17 C.F.R §§ 200.80(B)4, AND 240.24B-2

 

Exhibit 10.61

 

Execution Copy

AMENDMENT NO.2

 

This Amendment No.2 (“the “Amendment”) to the Collaboration, License and Development Agreement dated December 7th, 2012 (the “Agreement”), is made by and between

	
(1)

	
ASTRAZENECA AB, a company incorporated in Sweden under no. 556011-7482 with its registered office at 151 85 Södertälje, Sweden and with offices at SE-43 183 Mölndal, Sweden (“AstraZeneca”)

	
(2)

	
Isis Pharmaceuticals, Inc., a Delaware corporation, having its principal place of business at 2855 Gazelle Court, Carlsbad, CA 92010 (“Isis”)

and is made effective as of the 15th day of October, 2014 (the “Amendment Effective Date”)

Recitals

WHEREAS, the Parties desire to further amend, modify and restate certain terms and conditions of the Agreement.

Agreement

     NOW, THEREFORE, in consideration of the mutual covenants contained in this Amendment, and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Parties, intending to be legally bound, agree as follows:

	
1.

	
Definitions

Any capitalized term not separately defined in this Amendment shall have the meaning ascribed to it in the Agreement.

	
2.

	
Modifications

Article 8.4, Table 1, shall be deleted and replaced by the following:

 

	Table 1	  
	
STAT3 Product Milestone Event

	 	
Column 1

STAT3 Product Milestone Event Payment for High Response Outcome

	 	  	
Column 2

STAT3 Product Milestone Event Payment for Medium Response Outcome or Low Response Outcome

	 
	
[***]

	 	
$

	
[***]

	  	 	
$

	
[***]

	  
	
[***]

	  	
$

	
[***]

	 	 	
$

	
[***]

	 
	
[***]

	 	
$

	
[***]

	 	 	
$

	
[***]

	 
	
[***]

	 	
$

	
[***]

	 	 	
$

	
[***]

	 
	
[***]

	 	
$

	
[***]

	 	 	
$

	
[***]

	 
	
[***]

	 	
$

	
[***]

	 	 	
$

	
[***]

	 
	
[***]

	 	
$

	
[***]

	 	 	
$

	
[***]

	 
	
[***]

	 	
$

	
[***]

	 	 	
$

	
[***]

	 
	
[***]

	 	
$

	
[***]

	 	 	
$

	
[***]

	 
	
[***]

	 	
$

	
[***]

	 	 	
$

	
[***]

	 
	
[***]

	 	
$

	
[***]

	 	 	
$

	
[***]

	 
	
[***]

	 	
$

	
[***]

	  	  	
$

	
[***]

	 

 

	
3.

	
Amendment Effective Date

This Amendment shall become effective on the Amendment Effective Date.

	
4.

	
Entire Agreement

This Amendment, together with the Agreement, constitutes the entire agreement between the Parties with respect to the subject matter of the Agreeement. The Agreeemnt together with this Amendment and any prior Amendments thereto supersedes all prior agreements, whether written or oral, with respect to the subject matter of the Agreeemnet, as amended. Each Party confirms that it is not relying on any representations, warranties or covenants of the other Party except as specifically set out in the Agreement as amended. Nothing in this Agreement is intended to limit or exclude any liability or fraud. All Schedules referred to in this Amendment are intended to be and are hereby specifically incorporated into and made a part of the Agreement. The Parties hereby agree that subject to the modifciations specifically stated in this Amendment, all other terms and conditions of the Agreement shall remain in full force and effect.

Execution

THIS AGREEMENT IS EXECUTED by the authorized representatives of the parties as of the date first written above.

	
ASTRAZENECA AB

	 	
ISIS Pharmaceuticals, INC

	
	 			
	
Signature :  

	
/s/ M. Schindler

	 	
Signature :  

	
/s/ B. Lynne Parshall

	
	 					
	
Name :

	
M. Schindler

	 	
Name :

	
B. Lynne Parshall

	
	 					
	
Title :

	
16 10 14

	 	
Title :

	
Chief Operating OfficerEX-10.13

 Exhibit 10.13 

MedAssets, Inc. 
 MedAssets, Inc. Long-Term Performance
Incentive Plan 
 Restricted Stock Unit Award Agreement 

Date of Grant:  
 Vesting: RSUs shall be
subject to time-based vesting restrictions 
 THIS AGREEMENT, effective as of the Date of Grant, represents the grant of RSUs by MedAssets, Inc., a Delaware
corporation (the “Company”), to the Participant named above, pursuant to the Plan. The RSUs are subject to all of the terms and conditions set forth herein, as well as the terms and conditions of the Plan, all of which are incorporated
herein in their entirety. If there is any inconsistency between the terms of this Agreement and the terms of the Plan, the Plan’s terms shall completely supersede and replace the conflicting terms of this Agreement. All capitalized terms shall
have the meanings ascribed to them in the Plan, unless specifically set forth otherwise herein. The parties hereto agree as follows: 
  

	1.	Grant of the Award. The Company grants to the Participant, on the terms and conditions set forth in this Agreement, a number of RSUs, with each RSU corresponding to one share of Stock (subject to adjustment
pursuant to the Plan). 

  

	2.	Vesting of RSUs. Except as described in Sections 4 and 5 below, the Participant shall become vested in the RSUs on the applicable Vesting Dates as noted in the [    ] System provided that the
Participant has not undergone a Termination prior to such date. 

  

	3.	Settlement. Upon vesting of an RSU, the Company shall settle each RSU by delivering to the Participant one share of Stock for each RSU that vested as soon as practicable (and in no event later than the date that
is 2 1⁄2 months following the last day of the fiscal year in which the Vesting Date occurs) following the applicable Vesting Date. The Stock issued in respect
of the RSUs may be evidenced in such manner as the Committee shall determine. 

  

	4.	Termination of Service. Except as may otherwise be provided in an employment agreement or by the Committee, if, prior to the time an RSU has vested, the Participant undergoes a Termination for any reason, all
vesting with respect to the RSUs shall cease, and all of the Participant’s unvested RSUs shall be forfeited by the Participant to the Company for no consideration as of the date of such Termination. 

 

	5.	Change in Control. Notwithstanding anything to the contrary in this Agreement, in the event of a Change in Control of the Company prior to a Vesting Date and prior to the Participant’s Termination, the
treatment of unvested RSUs shall be governed by the terms of the Plan. 

  

	6.	Recapitalization. The adjustment provisions contained in Section 9 of the Plan are incorporated by reference herein and made a part hereof. 

 

	7.	Continuation of Employment. This Agreement shall not confer upon the Participant any right to continue employment with the Company, nor shall this Agreement interfere in any way with the Company’s right to
terminate the Participant’s employment at any time. 

  

	8.	Rights as Shareholder. The Participant shall not be entitled to any of the rights of a shareholder of the Company with respect to the RSUs, including the right to vote such shares and to receive dividends and any
other distributions, until and to the extent the RSUs are settled in shares of Stock. 

  

	9.	Section 409A. This Agreement and the RSUs granted to the Participant hereunder shall be construed and interpreted to comply with Section 409A of the Code. Any issuance of Stock in respect of a RSU
constituting nonqualified deferred compensation subject to Section 409A of the Code on account of a Termination shall (i) only be made upon a Termination to the extent it constitutes a “separation from service” within the meaning
of Section 409A of the Code and (ii) be delayed for such period as may be necessary to meet the requirements of Section 409A(a)(2)(B)(i) of the Code. 

	10.	Award Not Transferable. The RSUs may not be sold, transferred, pledged, assigned, or otherwise alienated or hypothecated, other than by will or by the laws of descent and distribution or pursuant to a qualified
domestic relations order. 

  

	11.	Recoupment. Notwithstanding the terms regarding vesting and forfeitability herein or in the Plan, Participant acknowledges and agrees that, as a condition of the grant of RSUs hereunder, all or a portion of the
RSUs granted hereunder will be forfeited, and any Stock acquired upon the vesting of such RSUs (and any proceeds from the disposition of all or portion of such Stock) will be subject to recoupment, in the discretion of the Committee, in the event
that: (i) the Committee determines that Participant materially breaches Participant’s employment or post-employment obligations to the Company and its Affiliates; or (ii) any forfeiture event set forth in any incentive compensation
clawback or recoupment policy approved by the Company (including any policy approved to comply with the listing standards of any national securities exchange or association on which the Stock is listed or as is otherwise required by the Dodd-Frank
Wall Street Reform and Consumer Protection Act or other applicable law) occurs. Participant further acknowledges and agrees that the adoption or amendment of any such clawback or recoupment policy on or after the date the RSUs are granted hereunder
shall in no event require the prior consent of Participant. In the event the Company is entitled to, and seeks, recoupment under this paragraph, Participant shall promptly reimburse the amount to which the Company is entitled to recoup hereunder. In
the event Participant fails to make prompt reimbursement of any such amount to which the Company is entitled to recoup and as to which the Company seeks recoupment hereunder, Participant acknowledges and agrees that the Company shall have the right
to: (i) deduct such amount from the compensation or other payments due to Participant from the Company or its Affiliates; or (ii) to take any other appropriate action to recoup such amount. The rights contained in this paragraph shall be
in addition to, and shall not limit, any other rights or remedies that the Company or its Affiliates may have under law or in equity, including, without limitation, any rights the Company and its Affiliates may have under any other agreement or
arrangement with the Participant to which the Participant has consented, or as permitted by law. 

  

	12.	Miscellaneous. 

  

	 	A.	This Agreement and the rights of the Participant hereunder are subject to all the terms and conditions of the Plan, as the same may be amended from time to time, as well as to such rules and regulations as the Committee
may adopt for administration of the Plan. The Committee shall have the right to impose such restrictions on any shares of Stock acquired pursuant to this Agreement, as it may deem advisable, including, without limitation, restrictions under
applicable federal securities laws, under the requirements of any stock exchange or market upon which such shares are then listed and/or traded, and under any blue sky or state securities laws applicable to such shares. It is expressly understood
that the Committee is authorized to administer, construe, and make all determinations necessary or appropriate to the administration of the Plan and this Agreement, all of which shall be binding upon the Participant. 

 

	 	B.	The Committee may terminate, amend, or modify this Award from time to time in accordance with the terms of the Plan. 

  

	 	C.	This grant of RSUs shall not confer any right to the Participant (or any other Participant) to be granted RSUs or other Awards in the future under the Plan. 

 

	 	D.	The Participant acknowledges and agrees that the Participant will be required to satisfy applicable withholding tax obligations, if any, as provided in the Plan. The Participant may elect, subject to any procedural
rules adopted by the Committee, to satisfy the withholding requirement, in whole or in part, by having the Company withhold shares of Company Stock having an aggregate Fair Market Value on the date the tax is to be determined, equal to the minimum
statutory amount required to be withheld. 

  

	 	E.	The Participant agrees to take all steps necessary to comply with all applicable provisions of federal and state securities laws in exercising his or her rights under this Agreement. 

 

	 	F.	This Agreement shall be subject to all applicable laws, rules and regulations, and to such approvals by any governmental agencies or national securities exchanges as may be required. 

	 	G.	This Agreement shall be governed by, and construed in accordance with, the laws of the state of Delaware, without reference to the principles of conflicts of laws thereof. 

 

	 	I.	To the extent any provision of this Agreement is held by a court of competent jurisdiction to be unenforceable or invalid for any reason, the remaining provisions of this Agreement shall not be affected by such holding
and shall continue in full force in accordance with their terms. 

  

	 	J.	The Participant agrees that the Company may deliver by email all documents relating to the Plan or the Award (including, without limitation, a copy of the Plan) and all other documents that the Company is required to
deliver to its security holders (including, without limitation, disclosures that may be required by the Securities and Exchange Commission). The Participant also agrees that the Company may deliver these documents by posting them on a website
maintained by the Company or by a third party under contract with the Company. If the Company posts these documents on a website, it shall notify the Participant by email.

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00241-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00241-of-00352.parquet"}]]