Document:

Registration Rights Agreement

 EXHIBIT 4.4 
 REGISTRATION RIGHTS AGREEMENT 
 This REGISTRATION RIGHTS AGREEMENT dated June 12, 2007
(the “Agreement”) is entered into by and among Discover Financial Services, a Delaware corporation (the “Company”), and Morgan Stanley & Co. Incorporated (“Morgan Stanley”), as representative (the
“Representative”) of the several initial purchasers listed on Schedule I (the “Initial Purchasers”) to the Purchase Agreement dated June 12, 2007 (the “Purchase Agreement”) with the Company. The Purchase Agreement
provides for the sale by the Company to the Initial Purchasers of $800,000,000 aggregate principal amount of the Company’s Securities (as defined below). As an inducement to the Initial Purchasers to enter into the Purchase Agreement, the
Company has agreed to provide to the Initial Purchasers and their direct and indirect transferees the registration rights set forth in this Agreement. The execution and delivery of this Agreement is a condition to the closing under the Purchase
Agreement. 
 In consideration of the foregoing, the parties hereto agree as follows: 
 1. Definitions. As used in this Agreement, the following terms shall have the following meanings: 
 “Business Day” shall mean any day that is not a Saturday, Sunday or other day on which commercial banks in New York City are authorized or
required by law to remain closed. 
 “Company” shall have the meaning set forth in the Preamble and shall also include the
Company’s successors. 
 “Exchange Act” shall mean the Securities Exchange Act of 1934, as amended from time to time.

 “Exchange Dates” shall have the meaning set forth in Section 2(a)(ii) hereof. 
 “Exchange Offer” shall mean the exchange offer by the Company of Exchange Securities for Registrable Securities pursuant to Section 2(a)
hereof. 
 “Exchange Offer Registration” shall mean a registration under the Securities Act effected pursuant to Section 2(a)
hereof. 
 “Exchange Offer Registration Statement” shall mean an exchange offer registration statement on Form S-4 (or, if
applicable, on another appropriate form) and all amendments and supplements to such registration statement, in each case including the Prospectus contained therein or deemed a part thereof, all exhibits thereto and any document incorporated by
reference therein. 

 “Exchange Securities” shall mean notes issued by the Company under the Indenture containing
terms identical to the Securities of the relevant series (except that the Exchange Securities will not be subject to restrictions on transfer or to any increase in annual interest rate for failure to comply with this Agreement) and to be offered to
Holders of Registrable Securities in exchange for Exchange Securities pursuant to the Exchange Offer. 
 “Free Writing Prospectus”
means each free writing prospectus (as defined in Rule 405 under the Securities Act) prepared by or on behalf of the Company or used or referred to by the Company in connection with the sale of the Securities or Exchange Securities. 
 “Holders” shall mean the Initial Purchasers, for so long as they own any Registrable Securities, and each of their successors, assigns and
direct and indirect transferees who become owners of Registrable Securities under the Indenture; provided that for purposes of Sections 4 and 5 of this Agreement, the term “Holders” shall include Participating Broker-Dealers.

 “Indemnified Person” shall have the meaning set forth in Section 5(c) hereof. 
 “Indemnifying Person” shall have the meaning set forth in Section 5(c) hereof. 
 “Indenture” shall mean the Indenture relating to the Securities and Exchange Securities dated as of June 12, 2007 between the Company and
U.S. Bank National Association, as trustee, as the same may be amended from time to time in accordance with the terms thereof. 
 “Initial Purchasers” shall have the meaning set forth in the preamble. 
 “Issuer Information” shall have the
meaning set forth in Section 5(a) hereof. 
 “Majority Holders” shall mean the Holders of a majority of the aggregate
principal amount of the outstanding Registrable Securities of a series; provided that whenever the consent or approval of Holders of a specified percentage of Registrable Securities of a series is required hereunder, any Registrable
Securities owned directly or indirectly by the Company or any of its subsidiaries shall not be counted in determining whether such consent or approval was given by the Holders of such required percentage or amount; and provided, further, that
if the Company shall issue any additional Securities under the Indenture prior to consummation of the Exchange Offer or, if applicable, the effectiveness of any Shelf Registration Statement, such additional Securities and the Registrable Securities
of the same series to which this Agreement relates shall be treated together as one class for purposes of determining whether the consent or approval of Holders of a specified percentage of Registrable Securities has been obtained. 
  

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 “Participating Broker-Dealers” shall have the meaning set forth in Section 4(a) hereof.

 “Person” shall mean an individual, partnership, limited liability company, corporation, trust or unincorporated organization, or
a government or agency or political subdivision thereof. 
 “Prospectus” shall mean the prospectus included in, or, pursuant to the
rules and regulations of the Securities Act, deemed a part of, a Registration Statement, including any preliminary prospectus, and any such prospectus as amended or supplemented by any prospectus supplement, including a prospectus supplement with
respect to the terms of the offering of any portion of the Registrable Securities covered by a Shelf Registration Statement, and by all other amendments and supplements to such prospectus, and in each case including any document incorporated by
reference therein. 
 “Purchase Agreement” shall have the meaning set forth in the Preamble. 
 “Registrable Securities” shall mean the Securities; provided that the Securities shall cease to be Registrable Securities (i) when
a Registration Statement with respect to such Securities has become effective under the Securities Act and such Securities have been exchanged or disposed of pursuant to such Registration Statement, (ii) when such Securities are eligible to be
sold pursuant to Rule 144(k) (or any similar provision then in force, but not Rule 144A) under the Securities Act or (iii) when such Securities cease to be outstanding. 
 “Registration Expenses” shall mean any and all expenses incident to performance of or compliance by the Company with this Agreement, including
without limitation: (i) all SEC, stock exchange or National Association of Securities Dealers, Inc. registration and filing fees, (ii) all fees and expenses incurred in connection with compliance with state securities or blue sky laws
(including reasonable fees and disbursements of counsel for any Underwriters or Holders in connection with blue sky qualification of any Exchange Securities or Registrable Securities), (iii) all expenses of any Persons in preparing or assisting
in preparing, word processing, printing and distributing any Registration Statement, any Prospectus, any Free Writing Prospectus and any amendments or supplements thereto, any underwriting agreements, securities sales agreements or other similar
agreements and any other documents relating to the performance of and compliance with this Agreement, (iv) all rating agency fees, (v) all fees and disbursements relating to the qualification of the Indenture under applicable securities
laws, (vi) the fees and disbursements of the Trustee and its counsel, (vii) the fees and disbursements of counsel for the Company and, in the case of a Shelf Registration Statement, the fees and disbursements of one counsel for the Holders
(which counsel shall be selected by the Majority Holders and which counsel may also be counsel for the Initial Purchasers) and (viii) the fees and disbursements of the independent public accountants of the Company including the expenses of any
special audits or “comfort” letters required by or incident to the performance of and compliance with this Agreement, but excluding fees and expenses of counsel to the Underwriters (other than fees and 

  

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expenses set forth in clause (ii) above) or the Holders and underwriting discounts and commissions, brokerage commissions and transfer taxes, if any,
relating to the sale or disposition of Registrable Securities by a Holder. 
 “Registration Statement” shall mean any registration
statement of the Company that covers any of the Exchange Securities or Registrable Securities pursuant to the provisions of this Agreement and all amendments and supplements to any such registration statement, including post-effective amendments, in
each case including the Prospectus contained therein or deemed a part thereof, all exhibits thereto and any document incorporated by reference therein. 
 “SEC” shall mean the United States Securities and Exchange Commission. 
 “Securities”
means the Floating Rate Senior Notes due 2010 of the Company and the 6.450% Senior Notes due 2017 of the Company to be purchased pursuant to the Purchase Agreement. Unless otherwise indicated, each series of Securities shall be treated as a separate
series hereunder. 
 “Securities Act” shall mean the Securities Act of 1933, as amended from time to time. 
 “Shelf Additional Interest Date” shall have the meaning set forth in Section 2(d) hereof. 
 “Shelf Effectiveness Period” shall have the meaning set forth in Section 2(b) hereof. 
 “Shelf Registration” shall mean a registration effected pursuant to Section 2(b) hereof. 
 “Shelf Registration Statement” shall mean a “shelf” registration statement of the Company that covers all or a portion of the
Registrable Securities (but no other securities unless approved by a majority of the Holders whose Registrable Securities are to be covered by such Shelf Registration Statement) on an appropriate form under Rule 415 under the Securities Act, or any
similar rule that may be adopted by the SEC, and all amendments and supplements to such registration statement, including post-effective amendments, in each case including the Prospectus contained therein or deemed a part thereof, all exhibits
thereto and any document incorporated by reference therein. 
 “Staff” shall mean the staff of the SEC. 
 “Trust Indenture Act” shall mean the Trust Indenture Act of 1939, as amended from time to time. 
 “Trustee” shall mean the trustee with respect to the Securities under the Indenture. 
  

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 “Underwriter” shall have the meaning set forth in Section 3(e) hereof. 
 “Underwritten Offering” shall mean an offering in which Registrable Securities are sold to an Underwriter for reoffering to the public.

 2. Registration Under the Securities Act. (a) To the extent not prohibited by any applicable law or applicable interpretations
of the Staff, the Company shall (i) cause to be filed within 270 days after the date hereof an Exchange Offer Registration Statement covering an offer to the Holders to exchange all the Registrable Securities for Exchange Securities and
(ii) use its reasonable best efforts to cause such Registration Statement to be declared effective within 330 days after the date hereof. The Company shall commence the Exchange Offer promptly after the Exchange Offer Registration Statement is
declared effective by the SEC and use its reasonable best efforts to complete the Exchange Offer not later than 360 days after the date hereof. 
 The Company shall commence the Exchange Offer by mailing the related Prospectus, appropriate letters of transmittal and other accompanying documents to each Holder stating, in addition to such other disclosures as are required by applicable
law, substantially the following: 
  

	(i)	that the Exchange Offer is being made pursuant to this Agreement and that all Registrable Securities validly tendered and not properly withdrawn will be accepted for exchange;

  

	(ii)	the dates of acceptance for exchange (which shall be a period of at least 20 Business Days from the date such notice is mailed) (the “Exchange Dates”);

  

	(iii)	that any Registrable Security not tendered will remain outstanding and continue to accrue interest but will not retain any rights under this Agreement, except as otherwise specified
herein; 

  

	(iv)	that any Holder electing to have a Registrable Security exchanged pursuant to the Exchange Offer will be required to (A) surrender such Registrable Security, together with the
appropriate letters of transmittal, to the institution and at the address and in the manner specified in the notice, or (B) effect such exchange otherwise in compliance with the applicable procedures of the depositary for such Registrable
Security, in each case prior to the close of business on the last Exchange Date; and 

  

	(v)	that any Holder will be entitled to withdraw its election, not later than the close of business on the last Exchange Date, by (A) sending to the institution and at the address
specified in the notice, a telegram, telex, facsimile transmission or letter setting forth the name of such Holder, the principal amount of Registrable Securities delivered for exchange and a statement that such Holder is withdrawing its election to
have such Securities exchanged or (B) effecting such withdrawal in compliance with the applicable procedures of the depositary for the Registrable Securities. 

  

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 As a condition to participating in the Exchange Offer, a Holder will be required to represent to the
Company that (i) any Exchange Securities to be received by it will be acquired in the ordinary course of its business, (ii) at the time of the commencement of the Exchange Offer it has no arrangement or understanding with any Person to
participate in the distribution (within the meaning of the Securities Act) of the Exchange Securities in violation of the provisions of the Securities Act, (iii) it is not an “affiliate” (within the meaning of Rule 405 under the
Securities Act) of the Company and (iv) if such Holder is a broker-dealer that will receive Exchange Securities for its own account in exchange for Registrable Securities that were acquired as a result of market-making or other trading
activities, then such Holder will deliver a Prospectus (or, to the extent permitted by law, make available a Prospectus to purchasers) in connection with any resale of such Exchange Securities. 
 As soon as practicable after the last Exchange Date, the Company shall: 
  

	(i)	accept for exchange Registrable Securities or portions thereof validly tendered and not properly withdrawn pursuant to the Exchange Offer; and 

  

	(ii)	deliver, or cause to be delivered, to the Trustee for cancellation all Registrable Securities or portions thereof so accepted for exchange by the Company and issue, and cause the
Trustee to promptly authenticate and deliver to each Holder, Exchange Securities equal in principal amount to the principal amount of the Registrable Securities tendered by such Holder and of the same series as such Registrable Securities.

 The Company shall use its reasonable best efforts to complete the Exchange Offer as provided above and shall comply in all
material respects with the applicable requirements of the Securities Act, the Exchange Act and other applicable laws and regulations in connection with the Exchange Offer. The Exchange Offer shall not be subject to any conditions, other than that
the Exchange Offer does not violate any applicable law or applicable interpretations of the Staff. 
 (b) In the event that (i) the
Company determines that the Exchange Offer Registration provided for in Section 2(a) above is not available or the Exchange Offer may not be completed as soon as practicable after the last Exchange Date because it would violate any applicable
law or applicable interpretations of the Staff, (ii) the Exchange Offer is not for any other reason completed by June 7, 2008, (iii) in the case of any Holder that participates in the Exchange Offer, such Holder does not receive
Exchange Securities on the date of the exchange that may be sold without restriction under state and federal securities laws (other than due solely to the status of such Holder as an affiliate of the Company within the meaning of the Securities Act
or as a broker-dealer) or (iv) the Company so elects, the Company shall (1) promptly deliver to the Holders written notice thereof and (2) at the Company’s sole expense, (a) file, as 

  

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promptly as practicable (but in no event more than 45 days after so required hereby), a Shelf Registration Statement providing for the sale of all the
Registrable Securities by the Holders thereof and (b) use the Company’s reasonable best efforts to cause the Shelf Registration Statement to be declared effective under the Securities Act. 
 The Company agrees to use its reasonable best efforts to keep the Shelf Registration Statement continuously effective until the expiration of the period
referred to in Rule 144(k) (or any similar rule then in force, but not Rule 144A) under the Securities Act with respect to the Registrable Securities or such shorter period that will terminate when all the Registrable Securities covered by the Shelf
Registration Statement have been sold pursuant to the Shelf Registration Statement (the “Shelf Effectiveness Period”). The Company further agrees to supplement or amend the Shelf Registration Statement, the related Prospectus and any Free
Writing Prospectus if required by the rules, regulations or instructions applicable to the registration form used by the Company for such Shelf Registration Statement or by the Securities Act or by any other rules and regulations thereunder or if
reasonably requested by a Holder of Registrable Securities with respect to information relating to such Holder, and to use its reasonable best efforts to cause any such amendment to become effective, if required, and such Shelf Registration
Statement, Prospectus or Free Writing Prospectus, as the case may be, to become usable as soon as thereafter practicable. The Company agrees to furnish to the Holders of Registrable Securities copies of any such supplement or amendment promptly
after its being used or filed with the SEC. 
 (c) The Company shall pay all Registration Expenses in connection with any registration
pursuant to Section 2(a) or Section 2(b) hereof. Each Holder shall pay all underwriting discounts and commissions, brokerage commissions and transfer taxes, if any, relating to the sale or disposition of such Holder’s Registrable
Securities pursuant to the Shelf Registration Statement. 
 (d) An Exchange Offer Registration Statement pursuant to Section 2(a) hereof
will not be deemed to have become effective unless it has been declared effective by the SEC. A Shelf Registration Statement pursuant to Section 2(b) hereof will not be deemed to have become effective unless it has been declared effective by
the SEC or is automatically effective upon filing with the SEC as provided in Rule 462 under the Securities Act. 
 If, with respect to any
series of Securities: (i) neither the Exchange Offer Registration Statement nor the Shelf Registration Statement is filed with the SEC on or prior to March 8, 2008, (ii) no Shelf Registration Statement has been filed and the Exchange
Offer Registration Statement is not declared effective on or prior to May 7, 2008, or (iii) the Exchange Offer is not consummated and the Shelf Registration Statement is not declared effective on or prior to June 7, 2008, then a
special interest premium (the “Special Interest Premium”) will accrue in respect of such series of the Securities from and including the next calendar day following each of (a) March 8, 2008 in the case of clause (i) above,
(b) May 7, 2008 in the case of clause (ii) above, and (c) June 7, 2008 in the case of clause (iii) above, in each case at a rate equal to 0.25% per 

  

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annum. If, with respect to any series of Securities, the Exchange Offer Registration Statement is not declared effective on or prior to May 7, 2008 and
the Company requests Holders of the Registrable Securities of such series to provide the information called for hereby for inclusion in the Shelf Registration Statement, the Registrable Securities of such series owned by Holders who do not deliver
such information to the Company when required hereby will not be entitled to any such increase in the interest rate for any day after May 7, 2008. With respect to a series of Securities, upon (1) the filing of an Exchange Offer
Registration Statement or a Shelf Registration Statement after March 8, 2008, (2) the effectiveness of the Exchange Offer Registration Statement or the filing of such Shelf Registration Statement after May 7, 2008 or (3) the
consummation of the Exchange Offer or the effectiveness of a Shelf Registration Statement, as the case may be, after June 7, 2008, the interest rate on the Registrable Securities of such series from the day of such filing, effectiveness or
consummation, as the case may be, will be reduced to the original interest rate for the Registrable Securities for such series. 
 If the Shelf Registration Statement, if required hereby, has become effective and thereafter
either ceases to be effective or the Prospectus contained therein ceases to be usable, in each case whether or not permitted by this Agreement, at any time during the Shelf Effectiveness Period, and such failure to remain effective or usable exists
for more than 120 days (whether or not consecutive) in any 12-month period, then the interest rate on the Registrable Securities of each affected series will be increased by 0.25% per annum commencing on the 121st day in such 12-month period and ending on such date that (i) the Shelf Registration Statement has again become effective
or the Prospectus again becomes usable, (ii) the date that is the second anniversary of the date hereof (or, if Rule 144(k) is amended to provide a shorter restrictive period, such shorter period) or (iii) the date as of which all of the
Registrable Securities are sold pursuant to the Shelf Registration Statement. 
 (e) Without limiting the remedies available to the Initial
Purchasers and the Holders, the Company acknowledges that any failure by the Company to comply with its obligations under Section 2(a) and Section 2(b) hereof may result in material irreparable injury to the Initial Purchasers or the
Holders for which there is no adequate remedy at law, that it may not be possible to measure damages for such injuries precisely and that, in the event of any such failure, the Initial Purchasers or any Holder may seek to obtain such relief as may
be required to specifically enforce the obligations of the Company under Section 2(a) and Section 2(b) hereof. 
 (f) It is
acknowledged and agreed that the Company shall be entitled to fulfill its obligations under this Agreement through the use of one or more Registration Statements; provided that the Company shall not be entitled to use more than one
Registration Statement for each series of Securities. 
 3. Registration Procedures. (a) In connection with its obligations
pursuant to Section 2(a) and Section 2(b) hereof, the Company shall: 
 (i) prepare and file with the SEC a Registration Statement
on the appropriate form under the Securities Act, which form (x) shall be selected by the Company, (y) shall, in the case of a Shelf Registration, be available for the sale of the Registrable Securities by the Holders thereof and
(z) shall comply as to form in all material respects with the requirements of the applicable form and include all financial statements required by the SEC to be filed therewith; and use its reasonable best efforts to cause such Registration
Statement to become effective and remain effective for the applicable period in accordance with Section 2 hereof; 
  

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 (ii) prepare and file with the SEC such amendments and post-effective amendments to each Registration
Statement as may be necessary to keep such Registration Statement effective for the applicable period in accordance with Section 2 hereof and cause each Prospectus to be supplemented by any required prospectus supplement and, as so
supplemented, to be filed pursuant to Rule 424 under the Securities Act; and keep each Prospectus current during the period described in Section 4(3) of and Rule 174 under the Securities Act that is applicable to transactions by brokers or
dealers with respect to the Registrable Securities or Exchange Securities; 
 (iii) to the extent any Free Writing Prospectus is used, file
with the SEC any Free Writing Prospectus that is required to be filed by the Company with the SEC in accordance with the Securities Act and to retain any Free Writing Prospectus not required to be filed; 
 (iv) in the case of a Shelf Registration, furnish to each Holder of Registrable Securities, to counsel for the Initial Purchasers, to counsel for such
Holders and to each Underwriter of an Underwritten Offering of Registrable Securities, if any, without charge, as many copies of each Prospectus, preliminary prospectus or Free Writing Prospectus, and any amendment or supplement thereto, as such
Holder, counsel or Underwriter may reasonably request in order to facilitate the sale or other disposition of the Registrable Securities thereunder; and the Company consents to the use of such Prospectus, preliminary prospectus or such Free Writing
Prospectus and any amendment or supplement thereto in accordance with applicable law by each of the Holders of Registrable Securities and any such Underwriters in connection with the offering and sale of the Registrable Securities covered by and in
the manner described in such Prospectus, preliminary prospectus or such Free Writing Prospectus or any amendment or supplement thereto in accordance with applicable law; 
 (v) use its reasonable best efforts to register or qualify the Registrable Securities under all applicable state securities or blue sky laws of such jurisdictions as any Holder of Registrable Securities covered by a
Registration Statement shall reasonably request in writing by the time the applicable Registration Statement becomes effective; cooperate with such Holders in connection with any filings required to be made with the National Association of
Securities Dealers, Inc.; and do any and all other acts and things that may be reasonably necessary or advisable to enable each Holder to complete the disposition in each such jurisdiction of the Registrable Securities owned by such Holder;
provided that the Company shall not be required to (1) qualify as a foreign 

  

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corporation or other entity or as a dealer in securities in any such jurisdiction where it would not otherwise be required to so qualify, (2) file any
general consent to service of process in any such jurisdiction or (3) subject itself to taxation in any such jurisdiction if it is not otherwise so subject; 
 (vi) notify counsel for the Initial Purchasers and, in the case of a Shelf Registration, notify each Holder of Registrable Securities and counsel for such Holders promptly and, if requested by any such Holder or
counsel, confirm such advice in writing (1) when a Registration Statement has become effective, when any post-effective amendment thereto has been filed and becomes effective, when any Free Writing Prospectus has been filed or any amendment or
supplement to the Prospectus or any Free Writing Prospectus has been filed, (2) of any request by the SEC or any state securities authority for amendments and supplements to a Registration Statement, Prospectus or any Free Writing Prospectus or
for additional information relating to the Registration Statement after the Registration Statement has become effective, (3) of the issuance by the SEC or any state securities authority of any stop order suspending the effectiveness of a
Registration Statement or the initiation of any proceedings for that purpose, including the receipt by the Company of any notice of objection of the SEC to the use of a Shelf Registration Statement or any post-effective amendment thereto pursuant to
Rule 401(g)(2) under the Securities Act, (4) if, between the applicable effective date of a Shelf Registration Statement and the closing of any sale of Registrable Securities covered thereby, the representations and warranties of the Company
contained in any underwriting agreement, securities sales agreement or other similar agreement, if any, relating to an offering of such Registrable Securities cease to be true and correct in all material respects or if the Company receives any
notification with respect to the suspension of the qualification of the Registrable Securities for sale in any jurisdiction or the initiation of any proceeding for such purpose, (5) of the happening of any event during the period a Registration
Statement is effective that makes any statement made in such Registration Statement or the related Prospectus or any Free Writing Prospectus untrue in any material respect or that requires the making of any changes in such Registration Statement or
Prospectus or any Free Writing Prospectus in order to make the statements therein not misleading and (6) of any determination by the Company that a post-effective amendment to a Registration Statement or any amendment or supplement to the
Prospectus or any Free Writing Prospectus would be appropriate; 
 (vii) use its reasonable best efforts to obtain the withdrawal of any
order suspending the effectiveness of a Registration Statement or, in the case of a Shelf Registration, the resolution of any objection of the SEC pursuant to Rule 401(g)(2), including by filing an amendment to such Shelf Registration Statement on
the proper form, at the earliest possible moment and provide prompt notice to each Holder of the withdrawal of any such order or such resolution; 
 (viii) in the case of a Shelf Registration, furnish to each Holder of Registrable Securities upon request, without charge, at least one conformed copy of each Registration Statement and any post-effective amendment thereto (without any
documents incorporated therein by reference or exhibits thereto, unless requested); 
  

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 (ix) in the case of a Shelf Registration, cooperate with the Holders of Registrable Securities to
facilitate the timely preparation and delivery of certificates representing Registrable Securities to be sold and not bearing any restrictive legends and enable such Registrable Securities to be issued in such denominations and registered in such
names (consistent with the provisions of the Indenture) as such Holders may reasonably request at least one Business Day prior to the closing of any sale of Registrable Securities; 
 (x) in the case of a Shelf Registration, upon the occurrence of any event contemplated by Section 3(a)(vi)(5) hereof, use its reasonable best
efforts to prepare and file with the SEC a supplement or post-effective amendment to such Shelf Registration Statement or the related Prospectus or any Free Writing Prospectus or any document incorporated therein by reference or file any other
required document so that, as thereafter delivered (or, to the extent permitted by law, made available) to purchasers of the Registrable Securities, such Prospectus or Free Writing Prospectus, as the case may be, will not contain any untrue
statement of a material fact or omit to state a material fact necessary to make the statements therein, in the light of the circumstances under which they were made, not misleading; and the Company shall notify the Holders of Registrable Securities
to suspend use of the Prospectus or any Free Writing Prospectus as promptly as practicable after the occurrence of such an event, and such Holders hereby agree to suspend use of the Prospectus or any Free Writing Prospectus, as the case may be,
until the Company has amended or supplemented the Prospectus or the Free Writing Prospectus, as the case may be, to correct such misstatement or omission; 
 (xi) a reasonable time prior to the filing of any Registration Statement, any Prospectus, any Free Writing Prospectus, any amendment to a Registration Statement or amendment or supplement to a Prospectus or a Free
Writing Prospectus after initial filing of a Registration Statement, provide copies of such document to the Initial Purchasers and its counsel and make such of the representatives of the Company as shall be reasonably requested by the Initial
Purchasers or their counsel available for discussion of such document; and the Company shall not, at any time after initial filing of a Registration Statement, use or file any Prospectus, any Free Writing Prospectus, any amendment of or supplement
to a Registration Statement, a Prospectus or a Free Writing Prospectus of which the Initial Purchasers and their counsel shall not have previously been advised and furnished a copy or to which the Initial Purchasers or their counsel shall reasonably
object; 
 (xii) obtain a CUSIP number for all Exchange Securities or Registrable Securities, as the case may be, not later than the initial
effective date of a Registration Statement; 
 (xiii) cause the Indenture to be qualified under the Trust Indenture Act in connection with
the registration of the Exchange Securities or Registrable Securities, as the case may be; cooperate with the Trustee and the Holders to effect such changes to the Indenture as may be required for the Indenture to be so qualified in accordance with
the 

  

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terms of the Trust Indenture Act; and execute, and use its reasonable best efforts to cause the Trustee to execute, all documents as may be required to
effect such changes and all other forms and documents required to be filed with the SEC to enable the Indenture to be so qualified in a timely manner; 
 (xiv) in the case of a Shelf Registration, make available for inspection by any Underwriter participating in any disposition pursuant to such Shelf Registration Statement, any attorneys and accountants designated by
Holders of a majority in aggregate principal amount of the Registrable Securities of each series to be included in such Shelf Registration and any attorneys and accountants designated by such Underwriter, at reasonable times and in a reasonable
manner, all pertinent financial and other records, documents and properties of the Company and its subsidiaries, and cause the officers, directors and employees of the Company to supply all information reasonably requested by any such Underwriter,
attorney or accountant in connection with a Shelf Registration Statement; provided that if any such information is identified by the Company as being confidential or proprietary, each Person receiving such information shall take such actions
as are reasonably necessary to protect the confidentiality of such information to the extent such action is otherwise not inconsistent with, an impairment of or in derogation of the rights and interests of any Inspector, Holder or Underwriter;

 (xv) if reasonably requested by any Holder of Registrable Securities covered by a Shelf Registration Statement, promptly include in a
Prospectus supplement or post-effective amendment such information with respect to such Holder as such Holder reasonably requests to be included therein and make all required filings of such Prospectus supplement or such post-effective amendment
reasonably promptly thereafter; and 
 (xvi) in the case of a Shelf Registration, enter into such customary agreements and take all such
other actions in connection therewith (including those requested by the Holders of a majority in principal amount of each series of the Registrable Securities covered by the Shelf Registration Statement) in order to expedite or facilitate the
disposition of such Registrable Securities including, but not limited to, an Underwritten Offering and in such connection, (1) to the extent possible, make such representations and warranties to the Holders and any Underwriters of such
Registrable Securities with respect to the business of the Company and its subsidiaries and the Registration Statement, Prospectus, any Free Writing Prospectus and documents incorporated by reference or deemed incorporated by reference, if any, in
each case, in form, substance and scope as are customarily made by issuers to underwriters in underwritten offerings and confirm the same if and when requested, (2) obtain opinions of counsel to the Company (which counsel and opinions, in form,
scope and substance, shall be reasonably satisfactory to such Underwriters and its counsel) addressed to each Underwriter of Registrable Securities, covering the matters customarily covered in opinions requested in underwritten offerings,
(3) obtain “comfort” letters from the independent certified public accountants of the Company (and, if necessary, any other certified public accountant of any subsidiary of the Company or of any business acquired by the Company for
which financial statements and financial data are or are required to be included in the 

  

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Registration Statement) addressed to each selling Holder (to the extent permitted by applicable professional standards) and Underwriter of Registrable
Securities, such letters to be in customary form and covering matters of the type customarily covered in “comfort” letters in connection with underwritten offerings, including but not limited to financial information contained in any
preliminary prospectus, Prospectus or Free Writing Prospectus and (4) deliver such documents and certificates as may be reasonably requested by the Holders of a majority in principal amount of the Registrable Securities of each series being
sold or the Underwriters, and which are customarily delivered in underwritten offerings, to evidence the continued validity of the representations and warranties of the Company made pursuant to clause (1) above and to evidence compliance with
any customary conditions contained in an underwriting agreement. 
 (b) In the case of a Shelf Registration Statement, the Company may
require each Holder of Registrable Securities to furnish to the Company such information regarding such Holder and the proposed disposition by such Holder of such Registrable Securities as the Company may from time to time reasonably request in
writing. 
 (c) In the case of a Shelf Registration Statement, each Holder of Registrable Securities covered in such Shelf Registration
Statement agrees that, upon receipt of any notice from the Company of the happening of any event of the kind described in Section 3(a)(vi)(3) or 3(a)(vi)(5) hereof, such Holder will forthwith discontinue disposition of Registrable Securities
pursuant to the Shelf Registration Statement until such Holder’s receipt of the copies of the supplemented or amended Prospectus and any Free Writing Prospectus contemplated by Section 3(a)(x) hereof and, if so directed by the Company such
Holder will deliver to the Company all copies in its possession, other than permanent file copies then in such Holder’s possession, of the Prospectus and any Free Writing Prospectus covering such Registrable Securities that is current at the
time of receipt of such notice. 
 (d) If the Company shall give any notice to suspend the disposition of Registrable Securities pursuant to
a Registration Statement, the Company shall extend the period during which such Registration Statement shall be maintained effective pursuant to this Agreement by the number of days during the period from and including the date of the giving of such
notice to and including the date when the Holders of such Registrable Securities shall have received copies of the supplemented or amended Prospectus or any Free Writing Prospectus necessary to resume such dispositions. The Company may give any such
notice only four times during any 365-day period and any such suspensions shall not exceed an aggregate of 120 days during any 365-day period. 
 (e) The Holders of Registrable Securities covered by a Shelf Registration Statement who desire to do so may sell such Registrable Securities in an Underwritten Offering. In any such Underwritten Offering, the investment bank or investment
banks and manager or managers (each an “Underwriter”) that will administer the offering will be selected by the Holders of a majority in principal amount of the Registrable Securities included in such offering. 
  

 13 

 4. Participation of Broker-Dealers in Exchange Offer. (a) Certain broker-dealers may receive
Exchange Securities for their own account in the Exchange Offer in exchange for Securities that were acquired by such broker-dealer as a result of market-making or other trading activities (a “Participating Broker-Dealer”) and may be
deemed to be an “underwriter” within the meaning of the Securities Act and may be required to deliver a prospectus meeting the requirements of the Securities Act in connection with any resale of such Exchange Securities. 
 The Company understands that it is the Staff’s position that if the Prospectus contained in the Exchange Offer Registration Statement includes a
plan of distribution containing a statement to the above effect and the means by which Participating Broker-Dealers may resell the Exchange Securities, without naming the Participating Broker-Dealers or specifying the amount of Exchange Securities
owned by them, such Prospectus may be delivered by Participating Broker-Dealers (or, to the extent permitted by law, made available to purchasers) to satisfy their prospectus delivery obligation under the Securities Act in connection with resales of
Exchange Securities for their own accounts, so long as the Prospectus otherwise meets the requirements of the Securities Act. 
 (b) In light
of the above, and notwithstanding the other provisions of this Agreement, to the extent required by the applicable rules of the SEC, the Company agrees to amend or supplement the Prospectus contained in the Exchange Offer Registration Statement for
a period of not less than 90 days after the last Exchange Date (as such period may be extended pursuant to Section 3(d) of this Agreement), in order to expedite or facilitate the disposition of any Exchange Securities by Participating
Broker-Dealers consistent with the positions of the Staff recited in Section 4(a) above. The Company further agrees that Participating Broker-Dealers shall be authorized to deliver such Prospectus (or, to the extent permitted by law, make
available) during such period in connection with the resales contemplated by this Section 4. 
 (c) The Initial Purchasers shall have no
liability to the Company or any Holder with respect to any request that they may make pursuant to Section 4(b) above. 
 5.
Indemnification and Contribution. (a) The Company agrees to indemnify and hold harmless each Initial Purchaser and each Holder, their respective affiliates, directors and officers and each Person, if any, who controls such Initial
Purchaser or any Holder within the meaning of Section 15 of the Securities Act or Section 20 of the Exchange Act, from and against any and all losses, claims, damages and liabilities (including, without limitation, legal fees and other
expenses incurred in connection with any suit, action or proceeding or any claim asserted, as such fees and expenses are incurred), joint or several, that arise out of, or are based upon, (1) any untrue statement or alleged untrue statement of
a material fact contained in any Registration Statement or any omission or alleged omission to state therein a material fact required to be stated therein or necessary in order to make the statements therein not misleading, or (2) any untrue
statement or alleged untrue statement of a material fact contained in any Prospectus, any Free Writing Prospectus or any “issuer information” (“Issuer Information”) filed or required to be filed pursuant to Rule 433(d) under the
Securities Act, or any omission or 

  

 14 

 
alleged omission to state therein a material fact necessary in order to make the statements therein, in the light of the circumstances under which they were
made, not misleading, in each case except insofar as such losses, claims, damages or liabilities arise out of, or are based upon, any untrue statement or omission or alleged untrue statement or omission made in reliance upon and in conformity with
any information relating to any Initial Purchaser or information relating to any Holder furnished to the Company in writing through any Initial Purchaser or any selling Holder, respectively, expressly for use therein. In connection with any
Underwritten Offering permitted by Section 3, the Company will also indemnify the Underwriters, if any participating in the distribution, their respective affiliates and each Person who controls such Persons (within the meaning of the
Securities Act and the Exchange Act) to the same extent as provided above with respect to the indemnification of the Holders, if requested in connection with any Registration Statement, any Prospectus, any Free Writing Prospectus or any Issuer
Information. 
 (b) Each Holder agrees, severally and not jointly, to indemnify and hold harmless the Company, the Initial Purchasers and the
other selling Holders, the directors of the Company, each officer of the Company who signed the Registration Statement and each Person, if any, who controls the Company, any Initial Purchaser and any other selling Holder within the meaning of
Section 15 of the Securities Act or Section 20 of the Exchange Act to the same extent as the indemnity set forth in paragraph (a) above, but only with respect to any losses, claims, damages or liabilities that arise out of, or are
based upon, any untrue statement or omission or alleged untrue statement or omission made in reliance upon and in conformity with any information relating to such Holder furnished to the Company in writing by such Holder expressly for use in any
Registration Statement, any Prospectus and any Free Writing Prospectus. 
 (c) If any suit, action, proceeding (including any governmental or
regulatory investigation), claim or demand shall be brought or asserted against any Person in respect of which indemnification may be sought pursuant to either paragraph (a) or (b) above, such Person (the “Indemnified Person”)
shall promptly notify the Person against whom such indemnification may be sought (the “Indemnifying Person”) in writing; provided that the failure to notify the Indemnifying Person shall not relieve it from any liability that it may
have under this Section 5 except to the extent that it has been materially prejudiced (through the forfeiture of substantive rights or defenses) by such failure; and provided, further, that the failure to notify the Indemnifying Person
shall not relieve it from any liability that it may have to an Indemnified Person otherwise than under this Section 5. If any such proceeding shall be brought or asserted against an Indemnified Person and it shall have notified the Indemnifying
Person thereof, the Indemnifying Person shall retain counsel reasonably satisfactory to the Indemnified Person to represent the Indemnified Person and any others entitled to indemnification pursuant to this Section 5 that the Indemnifying
Person may designate in such proceeding and shall pay the fees and expenses of such proceeding and shall pay the fees and expenses of such counsel related to such proceeding, as incurred. In any such proceeding, any Indemnified Person shall have the
right to retain its own counsel, but the fees and expenses of such counsel shall be at the expense of such Indemnified Person unless (i) the Indemnifying Person and the 

  

 15 

 
Indemnified Person shall have mutually agreed to the contrary; (ii) the Indemnifying Person has failed within a reasonable time to retain counsel
reasonably satisfactory to the Indemnified Person; (iii) the Indemnified Person shall have reasonably concluded that there may be legal defenses available to it that are different from or in addition to those available to the Indemnifying
Person; or (iv) the named parties in any such proceeding (including any impleaded parties) include both the Indemnifying Person and the Indemnified Person and representation of both parties by the same counsel would be inappropriate due to
actual or potential differing interests between them. It is understood and agreed that the Indemnifying Person shall not, in connection with any proceeding or related proceeding in the same jurisdiction, be liable for the fees and expenses of more
than one separate firm (in addition to any local counsel) for all Indemnified Persons, and that all such fees and expenses shall be reimbursed as they are incurred. Any such separate firm (x) for any Initial Purchaser, its affiliates, directors
and officers and any control Persons of such Initial Purchaser shall be designated in writing by the Initial Purchasers, (y) for any Holder, its directors and officers and any control Persons of such Holder shall be designated in writing by the
Majority Holders and (z) in all other cases shall be designated in writing by the Company. The Indemnifying Person shall not be liable for any settlement of any proceeding effected without its written consent, but if settled with such consent
or if there be a final judgment for the plaintiff, the Indemnifying Person agrees to indemnify each Indemnified Person from and against any loss or liability by reason of such settlement or judgment. Notwithstanding the foregoing sentence, if at any
time an Indemnified Person shall have requested that an Indemnifying Person reimburse the Indemnified Person for fees and expenses of counsel as contemplated by this paragraph, the Indemnifying Person shall be liable for any settlement of any
proceeding effected without its written consent if (i) such settlement is entered into more than 45 days after receipt by the Indemnifying Person of such request and (ii) the Indemnifying Person shall not have reimbursed the Indemnified
Person in accordance with such request prior to the date of such settlement. No Indemnifying Person shall, without the written consent of the Indemnified Person, effect any settlement of any pending or threatened proceeding in respect of which any
Indemnified Person is or could have been a party and indemnification could have been sought hereunder by such Indemnified Person, unless such settlement (A) includes an unconditional release of such Indemnified Person, in form and substance
reasonably satisfactory to such Indemnified Person, from all liability on claims that are the subject matter of such proceeding and (B) does not include any statement as to or any admission of fault, culpability or a failure to act by or on
behalf of any Indemnified Person. 
 (d) If the indemnification provided for in paragraphs (a) and (b) above is unavailable to an
Indemnified Person or insufficient in respect of any losses, claims, damages or liabilities referred to therein, then each Indemnifying Person under such paragraph, in lieu of indemnifying such Indemnified Person thereunder, shall contribute to the
amount paid or payable by such Indemnified Person as a result of such losses, claims, damages or liabilities (i) in such proportion as is appropriate to reflect the relative benefits received by the Company from the offering of the Securities
and the Exchange Securities, on the one hand, and by the Holders from receiving Securities or Exchange Securities registered under the Securities Act, on the other hand, or (ii) if the allocation 

  

 16 

 
provided by clause (i) is not permitted by applicable law, in such proportion as is appropriate to reflect not only the relative benefits referred to in
clause (i) but also the relative fault of the Company on the one hand and the Holders on the other in connection with the statements or omissions that resulted in such losses, claims, damages or liabilities, as well as any other relevant
equitable considerations. The relative fault of the Company on the one hand and the Holders on the other shall be determined by reference to, among other things, whether the untrue or alleged untrue statement of a material fact or the omission or
alleged omission to state a material fact relates to information supplied by the Company or by the Holders and the parties’ relative intent, knowledge, access to information and opportunity to correct or prevent such statement or omission.

 (e) The Company and the Holders agree that it would not be just and equitable if contribution pursuant to this Section 5 were
determined by pro rata allocation (even if the Holders were treated as one entity for such purpose) or by any other method of allocation that does not take account of the equitable considerations referred to in paragraph (d) above. The
amount paid or payable by an Indemnified Person as a result of the losses, claims, damages and liabilities referred to in paragraph (d) above shall be deemed to include, subject to the limitations set forth above, any legal or other expenses
incurred by such Indemnified Person in connection with any such action or claim. Notwithstanding the provisions of this Section 5, in no event shall a Holder be required to contribute any amount in excess of the amount by which the total price
at which the Securities or Exchange Securities sold by such Holder exceeds the amount of any damages that such Holder has otherwise been required to pay by reason of such untrue or alleged untrue statement or omission or alleged omission. No Person
guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the Securities Act) shall be entitled to contribution from any Person who was not guilty of such fraudulent misrepresentation. The Holders’ obligations to
contribute pursuant to this Section (5) are several and not joint. 
 (f) The remedies provided for in this Section 5 are not
exclusive and shall not limit any rights or remedies that may otherwise be available to any Indemnified Person at law or in equity. 
 (g)
The indemnity and contribution provisions contained in this Section 5 shall remain operative and in full force and effect regardless of (i) any termination of this Agreement, (ii) any investigation made by or on behalf of the Initial
Purchasers or any Holder or any Person controlling any Initial Purchaser or any Holder, or by or on behalf of the Company or the officers or directors of or any Person controlling the Company (iii) acceptance of any of the Exchange Securities
and (iv) any sale of Registrable Securities pursuant to a Shelf Registration Statement. 
 6. General. 
 (a) No Inconsistent Agreements. The Company represents, warrants and agrees that (i) the rights granted to the Holders hereunder do not in any
way conflict with and are not inconsistent with the rights granted to the holders of any other outstanding 

  

 17 

 
securities issued or guaranteed by the Company under any other agreement and (ii) the Company has not entered into, and on or after the date of this
Agreement will not enter into, any agreement that is inconsistent with the rights granted to the Holders of Registrable Securities in this Agreement or otherwise conflicts with the provisions hereof. 
 (b) Amendments and Waivers. The provisions of this Agreement, including the provisions of this sentence, may not be amended, modified or
supplemented, and waivers or consents to departures from the provisions hereof may not be given unless the Company has obtained the written consent of Holders of at least a majority in aggregate principal amount of each series of the outstanding
Registrable Securities affected by such amendment, modification, supplement, waiver or consent; provided that no amendment, modification, supplement, waiver or consent to any departure from the provisions of Section 5 hereof shall be
effective as against any Holder of Registrable Securities unless consented to in writing by such Holder. Any amendments, modifications, supplements, waivers or consents pursuant to this Section 6(b) shall be by a writing executed by each of the
parties hereto. 
 (c) Notices. All notices and other communications provided for or permitted hereunder shall be made in writing by
hand-delivery, registered first-class mail, telex, telecopier, or any courier guaranteeing overnight delivery (i) if to a Holder, at the most current address given by such Holder to the Company by means of a notice given in accordance with the
provisions of this Section 6(c), which address initially is, with respect to the Initial Purchasers, the address set forth in the Purchase Agreement; (ii) if to the Company, initially at the Company’s address set forth in the Purchase
Agreement and thereafter at such other address, notice of which is given in accordance with the provisions of this Section (6)(c); and (iii) to such other persons at their respective addresses as provided in the Purchase Agreement and
thereafter at such other address, notice of which is given in accordance with the provisions of this Section 6(c). All such notices and communications shall be deemed to have been duly given: at the time delivered by hand, if personally
delivered; five Business Days after being deposited in the mail, postage prepaid, if mailed; when answered back, if telexed; when receipt is acknowledged, if telecopied; and on the next Business Day if timely delivered to an air courier guaranteeing
overnight delivery. Copies of all such notices, demands or other communications shall be concurrently delivered by the Person giving the same to the Trustee, at the address specified in the Indenture. 
 (d) Successors and Assigns. This Agreement shall inure to the benefit of and be binding upon the successors, assigns and transferees of each of
the parties, including, without limitation and without the need for an express assignment, subsequent Holders; provided that nothing herein shall be deemed to permit any assignment, transfer or other disposition of Registrable Securities in
violation of the terms of the Purchase Agreement or the Indenture. If any transferee of any Holder shall acquire Registrable Securities in any manner, whether by operation of law or otherwise, such Registrable Securities shall be held subject to all
the terms of this Agreement, and by taking and holding such Registrable Securities such Person shall be conclusively deemed to have agreed to be 

  

 18 

 
bound by and to perform all of the terms and provisions of this Agreement and such Person shall be entitled to receive the benefits hereof. The Initial
Purchasers (in their capacity as Initial Purchasers) shall have no liability or obligation to the Company with respect to any failure by a Holder to comply with, or any breach by any Holder of, any of the obligations of such Holder under this
Agreement. 
 (e) Third Party Beneficiaries. Each Holder shall be a third party beneficiary to the agreements made hereunder between
the Company, on the one hand, and the Initial Purchasers, on the other hand, and shall have the right to enforce such agreements directly to the extent it deems such enforcement necessary or advisable to protect its rights or the rights of other
Holders hereunder. 
 (f) Counterparts. This Agreement may be executed in any number of counterparts and by the parties hereto in
separate counterparts, each of which when so executed shall be deemed to be an original and all of which taken together shall constitute one and the same agreement. 
 (g) Headings. The headings in this Agreement are for convenience of reference only, are not a part of this Agreement and shall not limit or otherwise affect the meaning hereof. 
 (h) Governing Law. This Agreement shall be governed by and construed in accordance with the laws of the State of New York. 
 (j) Entire Agreement; Severability. This Agreement contains the entire agreement between the parties relating to the subject matter hereof and
supersedes all oral statements and prior writings with respect thereto. If any term, provision, covenant or restriction contained in this Agreement is held by a court of competent jurisdiction to be invalid, void or unenforceable or against public
policy, the remainder of the terms, provisions, covenants and restrictions contained herein shall remain in full force and effect and shall in no way be affected, impaired or invalidated. The Company and the Initial Purchasers shall endeavor in good
faith negotiations to replace the invalid, void or unenforceable provisions with valid provisions the economic effect of which comes as close as possible to that of the invalid, void or unenforceable provisions. 
  

 19 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written above.

  

			
	DISCOVER FINANCIAL SERVICES
		
	By:	 	 /s/ Roy A. Guthrie
  

	Name:	 	Roy A. Guthrie
	Title:	 	Chief Financial Officer

  

 Signature Page to Registration Rights Agreement 

 Confirmed and accepted as of the date first above written: 
  

			
	MORGAN STANLEY & CO. INCORPORATED
		
	By	 	 /s/ Yurij Slyz
  

		 	Authorized Signatory

  

 Signature Page to Registration Rights AgreementAmended and Restated Stock Purchase and Sale Agreement

 EXHIBIT 10.1 
 For further information contact: 
 Dr Paul D’Sylva 
 CEO 
 Commonwealth Biotechnologies, Inc. 
 858 699 0298 
 Dr. John P McAlister

 CEO 
 Tripos, Inc. 
 314 616.4473 
 AMENDED AND RESTATED STOCK
PURCHASE AND SALE AGREEMENT 
 by and among 
 Tripos, Inc., 
 a Utah corporation, 
 Tripos UK Holdings Limited, 
 a private limited company incorporated in England,

 and 
 Commonwealth
Biotechnologies, Inc., 
 a Virginia corporation 
 Dated as of June 6, 2007 

 TABLE OF CONTENTS 
  

					
	  	  	Page
	 ARTICLE 1
	  	1
	 PURCHASE AND SALE OF SHARES
	  	1
	 1.1.      Sale and Delivery of Shares.
	  	1
	 ARTICLE 2
	  	2
	 PURCHASE PRICE
	  	2
	 2.1.      Payment of Purchase Price.
	  	2
	 ARTICLE 3
	  	2
	 REPRESENTATIONS AND WARRANTIES OF SELLER
	  	2
	 3.2       Organization, Good Standing and Qualification.
	  	2
	 3.3       Capitalization.
	  	2
	 3.4       Corporate Authority and Approvals.
	  	2
	 3.5       Title to Shares and Assets.
	  	3
	 3.6       Government Filings; No Violations or Conflicts.
	  	3
	 3.7       Litigation.
	  	3
	 3.8       Brokers.
	  	3
	 3.9       Compliance with Laws, Permits.
	  	3
	 3.10     Environmental Matters.
	  	3
	 3.11     Labor Matters.
	  	4
	 3.12     Intellectual Property.
	  	4
	 ARTICLE 4
	  	5
	 REPRESENTATIONS AND WARRANTIES OF PURCHASER
	  	5
	 4.1       Organization and Authority.
	  	5
	 4.2       Compliance with Other Instruments.
	  	6
	 4.3       Brokers.
	  	6
	 ARTICLE 5
	  	7
	 COVENANTS OF PURCHASER
	  	7
	 5.1       Additional Advances.
	  	7
	 5.2       Employee Matters.
	  	7
	 5.3       Filing Assistance.
	  	7
	 5.4       Use of Name.
	  	7
	 5.5       Post-Closing Collections.
	  	7
	 5.6       DTI Repayment and Consent.
	  	8
	 ARTICLE 6
	  	8
	 6.1       Representations and Warranties.
	  	8
	 6.2       Absence of Litigation.
	  	9
	 6.3       Consents and Approvals.
	  	9
	 6.4       SWERDA Transaction.
	  	9
	 6.5       Equipment Lessor Consent.
	  	9
	 6.6       License Agreement.
	  	9
	 6.8       Prior Intercompany Liabilities.
	  	9
	ARTICLE 7	  	9
	CONDITIONS PRECEDENT TO SELLER’S OBLIGATIONS	  	9
	 7.1       Representations and Warranties.
	  	9
	 7.2       Absence of Litigation.
	  	9
	 7.3       Consents and Approvals.
	  	10
	 7.4       SWERDA Transaction.
	  	10
	 7.5       U.S. Employees.
	  	10
	 7.6       UK Executives.
	  	10
	 7.7       Board Approval.
	  	10
	ARTICLE 8	  	11
	 CLOSING
	  	11

  

 i 

					
	 8.1       Closing.
	  	11
	 8.2       Deliveries by Parent and Seller.
	  	11
	 8.3       Deliveries by Purchaser.
	  	11
	 8.4       Cost Reimbursement.
	  	11
	 ARTICLE 9
	  	12
	 MISCELLANEOUS
	  	12
	 9.1       Survival of Representations and Warranties.
	  	12
	 9.2       Publicity.
	  	12
	 9.3       Commercially Reasonable Efforts.
	  	12
	 9.4       Further Acts and Assurances.
	  	12
	 9.5       Notices.
	  	12
	 9.6       Construction.
	  	13
	 9.7       Knowledge.
	  	13
	 9.8       Attachments.
	  	13
	 9.9       Parties Bound by Agreement.
	  	14
	 9.10     Counterparts.
	  	14
	 9.11     Headings.
	  	14
	 9.12     Modification and Waiver.
	  	14
	 9.13     Severability.
	  	14
	 9.14     Access to Records.
	  	14
	 9.15     Entire Agreement.
	  	14
	 9.16     Certain Definitions.
	  	15

  

 ii 

 AMENDED AND RESTATED STOCK PURCHASE AND SALE AGREEMENT 
 THIS AMENDED AND RESTATED STOCK PURCHASE AND SALE AGREEMENT (this “Agreement”), made and
entered into this 6th day of June, 2007, by and among Tripos, Inc., a Utah corporation (“Parent”), Tripos
UK Holdings Limited, a wholly-owned subsidiary of Parent and a private limited company incorporated in England (“Seller”), and, Commonwealth Biotechnologies, Inc., a Virginia corporation (“Purchaser”). 
 RECITALS 
 1. Seller is the owner of a
discovery research business (the “Business”) conducted through the operation of its wholly-owned subsidiary Tripos Discovery Research Ltd. (“TDR”); 
 2. Purchaser desires to purchase from Seller, and Seller desires to sell to Purchaser, all of the issued and outstanding share capital of TDR comprising 101,000 shares of £1.00 each (the “Acquired
Shares”), which transfer shall cause the Purchaser to own one hundred percent (100%) of TDR, all for the purchase price and subject to the terms and conditions set forth in this Agreement; and 
 3. On May 11, 2007, Seller and Purchaser entered into a Stock Purchase and Sale Agreement. 
 4. On May 12, 2007, Purchaser remitted to Seller $350,000 as a non-refundable deposit for the purchase price hereunder. 
 NOW, THEREFORE, in consideration of the premises and the representations, warranties, covenants and agreements contained herein, the receipt and
sufficiency of which are hereby acknowledged, the parties hereto, intending to be legally bound, hereby agree as follows: 
 ARTICLE 1

 PURCHASE AND SALE OF SHARES 
 1.1. Sale and Delivery of Shares. Subject to the terms and conditions hereof, Seller agrees to sell, assign, transfer and deliver, or cause to be sold, assigned, transferred and delivered, to Purchaser, and Purchaser agrees to
purchase and accept from Seller at the “Closing” (as hereinafter defined), all of Seller’s right, title and interest in and to the Acquired Shares for the Purchase Price (as defined in Article 2 hereof). 

 ARTICLE 2 
 PURCHASE PRICE 
 2.1. Payment of Purchase Price. The total consideration for the Acquired
Shares (the “Purchase Price”) shall be three hundred fifty thousand dollars US ($350,000.00) (the “Consideration”). Purchaser delivered to the Seller the Purchase Price on May 12, 2007. 
 ARTICLE 3 
 REPRESENTATIONS AND WARRANTIES
OF SELLER 
 Except as set forth in the Seller disclosure schedule attached to this Agreement (the “Seller Disclosure
Schedule”) (with respect to which any particular reference to a section or subsection of this Agreement shall be deemed to be disclosed under all other sections or subsections of this Agreement), each of the Seller and Parent hereby represents
and warrants to Purchaser that: 
 3.2 Organization, Good Standing and Qualification. Parent is a corporation duly organized, validly
existing and in good standing under the laws of the State of Utah, and each of Seller and TDR is a limited company duly incorporated and validly existing under the laws of England and Wales. Seller and TDR each has all requisite corporate or similar
power and authority to own and operate its properties and assets and to carry on its business as presently conducted and is qualified to do business in each jurisdiction where the ownership or operation of its properties or conduct of its business
requires such qualification. 
 3.3 Capitalization. The Acquired Shares constitute the entire allotted and issued share capital of TDR
and are fully paid or credited as fully paid. Seller is the sole legal and beneficial owner of the entire allotted and issued share capital of TDR. The issued shares of TDR are fully paid up and, free from Encumbrances. There are no preemptive or
other outstanding rights, options, warrants, conversion rights, redemption rights or repurchase rights to issue or sell any shares of TDR or any securities or obligations convertible or exchangeable into or exercisable for, or giving any Person a
right to subscribe for or acquire, any securities of TDR. 
 3.4 Corporate Authority and Approvals. Each of Parent and Seller has the
necessary corporate power and authority and has taken all corporate action necessary in order to execute, deliver and perform its obligations under this Agreement and to carry out and complete the sale of the Acquired Shares. The execution and
delivery of this Agreement by Parent and Seller and the consummation by Parent and Seller of the transactions contemplated hereby have been duly and validly authorized by all necessary corporate action and no other corporate proceedings on the part
of Parent or Seller are necessary to authorize this Agreement or to consummate the transactions contemplated hereby to the extent required under the UBCA or the laws of England or Wales. This Agreement has been duly executed and delivered by both
Parent and Seller and, assuming the due authorization, execution and delivery by Purchaser, constitutes a legal, valid and binding obligation of both Parent and Seller, enforceable against Parent and Seller in accordance with its terms, except as
such enforceability may be limited in either case by 

  

 2 

 
bankruptcy, insolvency, reorganization, moratorium and other similar laws of general applicability relating to or affecting creditors’ rights generally
and by the application of general principles of equity (regardless of whether enforcement is sought in a proceeding at law or in equity). 
 3.5 Title to Shares and Assets. The Seller has marketable title to the Acquired Shares free and clear of all Encumbrances. Except as set forth in Section 3.4 of the Seller Disclosure Schedule, and except for capital
leases or security to Parent for advances made to TDR, Seller has marketable title to all of the assets of the Business, free and clear of all Encumbrances, except liens for taxes not yet due and payable. 
 3.6 Government Filings; No Violations or Conflicts. Except as set forth in Section 3.5 of the Seller Disclosure Schedule, the
execution and delivery of this Agreement by Parent and Seller do not, and the performance by Parent and Seller of their respective obligations under this Agreement will not, (i) conflict with or violate the organizational documents of Parent,
Seller, or TDR, or (ii) conflict with or violate any law, statute, ordinance, rule, regulation, order, judgment or decree applicable to Parent, Seller or TDR. 
 3.7 Litigation. No suit, proceeding, hearing or governmental investigation is pending or, to the knowledge of Seller, threatened in writing against Seller or TDR. 
 3.8 Brokers. Neither Parent, Seller nor any of their executive officers, directors or employees has employed any broker or finder or incurred any
liability for any brokerage fees, commissions or finders fees in connection with the transactions contemplated by this Agreement, except that for any agreement with Seven Hills Partners LLC for financial advisory services rendered to Parent at sole
expense of Parent. 
 3.9 Compliance with Laws, Permits. TDR holds all permits, licenses and approvals (none of which has been
modified or rescinded and all of which are in full force and effect) from all necessary for TDR to carry on the Business as presently conducted (collectively, the “Permits”). The Business is not being conducted in material violation
of any applicable law, statute, ordinance, regulation, judgment, Permit, order, decree, concession, grant or other authorization of any Governmental Entity. 
 3.10 Environmental Matters.  
  

	 	(a)	In this Section 3.9: 

 (1)
“Dangerous Substance” means any natural or artificial substance (whether solid, liquid or gas and whether alone or in combination with any other substance or radiation) capable of causing harm to any human or other living organism or
damaging the Environment, public health or welfare. 
 (2) “Environment” means the environmental media of air, water
and land, all living organisms and natural or man-made structures. 
  

 3 

 (3) “Environmental Law” means all law in England and Wales relating to the
protection of human health or the Environment, the conditions of the workplace or the generation, transportation, storage, treatment, emission or disposal of a Dangerous Substance or Waste. 
 (4) “Environmental License” means any authorization, license, consent or permission required under any Environmental Law.

 (5) “Waste” means any unwanted or surplus substance irrespective of whether it is capable of being recycled or
recovered or has any value. 
 (b) TDR has at all times complied in all material respects with Environmental Law and obtained, and complied
with, all Environmental Licenses necessary for carrying on the Business and is not in material breach of any Environmental Law. 
 (c) The
Environmental Licenses necessary for carrying on the Business are in full force and effect and there are no circumstances existing which will give rise to the suspension or revocation of, to lead to the imposition of unusual or onerous conditions
on, or to prejudice the renewal of, any of those licenses. 
 3.11 Labor Matters.  
 (a) Seller has made available to Purchaser copies of all standard form contracts and handbooks and policies which apply to the employees, officers and
directors of TDR. 
 (b) There is no outstanding claim against TDR by any Person who is now or has been an employee or officer of TDR.

 (c) TDR is not party to any collective bargaining agreement with any trade union or staff association other than as required by government
regulation. 
 (d) TDR has not formally recognized a trade union and is not a party to any agreement with any trade union or group or
organization representing employees in respect of its employees. 
 (e) TDR has not in the last six (6) years provided, or agreed to
provide, any loan, gratuitous payment or gratuitous benefit to any of its directors, officers or employees or any of their dependants which remains outstanding. 
 3.12 Intellectual Property. 
 (a) For purposes of this Section 3.11, “Business Intellectual
Property” means all of the: (i) patents and patent applications; (ii) registered trademarks and trademark applications and material unregistered trademarks; (iii) copyrights; and (iv) registered domain names owned by TDR and
used in the Business. 
  

 4 

 (b) The registrations in connection with the Business Intellectual Property are valid and subsisting, all
necessary registration and renewal fees in connection with such registrations have been paid, and all necessary documents and certificates in connection with such registrations have been filed with the relevant authorities for the purposes of
maintaining such registrations. 
 (c) There are no contracts, licenses and agreements between Parent, Seller or TDR, on the one hand, and
any other Person, on the other hand, relating primarily to the Business Intellectual Property as to which there is any dispute regarding the scope of such agreement, or performance under such agreement including with respect to any payments to be
made or received by TDR thereunder. 
 (d) Neither Parent, Seller or TDR has received notice from any Person that the operation of the
Business, including the design, development, manufacture and sale of products and provision of services infringes the intellectual property of any Person. 
 (e) To the knowledge of Parent and Seller, no Person is materially infringing any of the Business Intellectual Property. 
 ARTICLE 4 
 REPRESENTATIONS AND WARRANTIES OF PURCHASER 
 Purchaser hereby represents and warrants to Seller as follows: 
 4.1 Organization and Authority. 
 (a) Purchaser is a corporation duly incorporated, validly existing
and in good standing under the laws of the Commonwealth of Virginia. Purchaser has all requisite corporate power and authority to execute and deliver this Agreement and perform its obligations hereunder. 
 (b) The execution and delivery of this Agreement by Purchaser and the performance of its obligations hereunder, have been duly authorized by all
necessary corporate action on the part of Purchaser. This Agreement has been duly executed and delivered by Purchaser and constitutes a valid and binding obligation of Purchaser, enforceable against Purchaser in accordance with its terms, except as
such enforceability may be limited by bankruptcy, insolvency, reorganization, moratorium and other similar laws of general applicability relating to or affecting creditors’ rights generally and by the application of general principles of equity
(regardless of whether enforcement is sought in a proceeding at law or in equity). 
  

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 4.2 Compliance with Other Instruments. The execution and delivery of this Agreement by Purchaser
and the performance by Purchaser of its obligations hereunder will not (a) conflict with or result in any violation of the organizational documents of Purchaser or (b) conflict with or violate any judgment, decree, law or order applicable
to Purchaser. 
 4.3 Brokers. No finder, broker, agent or other intermediary has acted for or on behalf of Purchaser in connection
with the negotiation and consummation of this Agreement or the transactions contemplated hereby. 
  

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 ARTICLE 5 
 COVENANTS OF PURCHASER 
 Purchaser covenants and agrees with Seller as follows: 
 5.1 Additional Advances. From and after May 14, 2007, Tripos has made advances of (a) £100,000, which is payable on or before
June 30, 2007 on the terms contained in a Promissory Note dated May 24, 2007, and (b) £135,599.79, which has become due and payable on the date hereof. 
 5.2 Employee Matters. Purchaser acknowledges that it is a successor to the Business, and undertakes to obtain any consents required under
applicable law, to terminate any liability of Parent or Seller for any unemployment compensation payments required to be made to any state or county (or a fund maintained by it) after the Closing Date with respect to any Employees of the Business.

 5.3 Filing Assistance. Purchaser shall, upon request by Parent, furnish Parent with all information concerning itself, its
subsidiaries, directors, executive officers and stockholders and such other matters as may be reasonably necessary or advisable in connection with any statement, filing, notice or application made by or on behalf of Parent or Seller to any third
party or any Governmental Entity in connection with the transactions contemplated by this Agreement. 
 5.4 Use of Name.
Notwithstanding any other provision of this Agreement, from the Closing Date, Purchaser shall not, without the prior written consent of Parent, utilize the name “Tripos” or any similar name other than in accordance with the terms of the
Software License Agreement, dated March 20, 2007, between TDR and Tripos, L.P. (the “License Agreement”). 
 5.5
Post-Closing Collections. 
 (a) On and following the Closing Date but subject to Section 5.5(c), Parent shall have the right to
retain all collections otherwise payable to TDR on the receivables described in Exhibit A hereto and to offset on a dollar-for-dollar basis these amounts against amounts owed to Parent or its affiliates (other than TDR) by TDR. Purchaser shall not
take (nor permit TDR to take) any action to hinder such collection and application. 
  

 7 

 (b) As of the date hereof, Schering-Plough has ordered from Parent compounds valued at $1,598,284 and
represented by Purchase Order 0000303433 dated March 14, 2007, of which approximately $471,872 remains to be shipped and billed (the “Pending Order”). Parent shall bill the Pending Order on the same basis as it has billed the initial
portion of the order and similar orders prior to the date hereof. Subject to Section 5.5(c), Parent shall be entitled to retain the full proceeds of the Pending Order. The parties agree that these receipts shall be applied to prior unpaid
advances and that the Parent shall also forgive $20,000 of unpaid advances as compensation to TDR for costs to be incurred in finishing this order. 
 (c) The maximum amount to which Parent and its affiliates shall be entitled under this Section 5.5 shall be $1.8 million. To the extent that Parent and its affiliates received any amounts under this Section 5.5 in excess of $1.8
million, Parent shall promptly remit such excess amount to Purchaser. On the Closing Date all amounts held by Parent representing collections of receivables referenced on Exhibit A (for purposes of illustration only, approximately $1.2 million)
shall be applied, dollar for dollar, to reduce the balance owed under this Section 5.5(c). 
 5.6 DTI Repayment and Consent. In
response to a request for repayment by the U.K. Department of Trade and Industry (“DTI”), Parent and Seller shall allocate and restrict twenty percent (20%) of the proceeds of the SWERDA Arrangement for immediate repayment of prior
grants by DTI, upon which DTI shall release from escrow the definitive agreement relating thereto, which is presently being held by DTI in escrow. 
 ARTICLE 6 
 CONDITIONS PRECEDENT TO PURCHASER’S OBLIGATIONS 
 The obligations of Purchaser to consummate the transactions contemplated by this Agreement are subject to the satisfaction of each of the following
conditions prior to or at the Closing, unless specifically waived in writing by Purchaser in advance: 
 6.1 Representations and
Warranties. 
 (a) The representations and warranties of Parent and Seller contained in this Agreement shall be true and
correct in all respects as of the date of this Agreement. 
 (b) Each of Parent and Seller shall have duly performed and
complied in all respects with all covenants, agreements and conditions required by this Agreement to be performed or complied with by Seller prior to or at the Closing. 
 (c) Seller shall have delivered a certificate executed by a duly authorized officer to Purchaser to the foregoing effect. 
  

 8 

 6.2 Absence of Litigation. No order, writ, injunction or decree which is binding on Purchaser,
Parent and/or Seller and which prohibits Purchaser, Parent and/or Seller from consummating the transactions contemplated hereby shall be in effect; provided that Purchaser shall have used its commercially reasonable efforts to have any such order,
writ, injunction or decree lifted and the same shall not have been lifted by any such court or governmental or regulatory agency. 
 6.3
Consents and Approvals. All governmental and regulatory approvals requisite or appropriate to the consummation of the transactions contemplated herein shall have been obtained (or all applicable waiting periods shall have expired) and shall
remain in full force and effect. 
 6.4 SWERDA Transaction. Parent, Seller, TDR, Purchaser and the South West of England Regional
Development Agency (“SWERDA”) shall have executed one or more definitive agreements (together, the “SWERDA Arrangement”) pursuant to which (i) TDR shall sell to SWERDA, and SWERDA shall subsequently leaseback to TDR, the
property at Bude-Stratton Business Park, Bude, Cornwall, EX23 8LY, (ii) SWERDA shall consent to the transactions contemplated hereby, and (iii) SWERDA shall release each of Parent, Seller and TDR from all repayment liabilities and related
guaranties. 
 6.5 Equipment Lessor Consent. A consent shall have been obtained from CSI Leasing UK Ltd. (the “Equipment
Lessor”) with respect to all existing equipment leases between TDR and the Equipment Lessor. 
 6.6 License Agreement. The
License Agreement shall be in full force and effect. 
 6.7 Board Approval. 
 The boards of directors of both Parent and Seller shall have approved the execution of this Agreement and the transactions related
thereto. 
 6.8 Prior Intercompany Liabilities. Except to the extent of amounts to be repaid under Sections 5.5 or intercompany
liabilities listed on Exhibit B, all intercompany liabilities between (i) Parent or Seller, on the one hand, and (ii) TDR, on the other hand, will be fully discharged and cancelled in a manner mutually satisfactory to Parent and Purchaser.

 ARTICLE 7 
 CONDITIONS
PRECEDENT TO SELLER’S OBLIGATIONS 
 The obligations of Seller to consummate the transactions contemplated by this Agreement are
subject to the satisfaction prior to or at the Closing of each of the following conditions, unless specifically waived in writing by Seller in advance: 
 7.1 Representations and Warranties.  
 (a) The representations and warranties of
Purchaser contained in this Agreement shall be true and correct as of the date of this Agreement. 
  

 9 

 (b) Purchaser shall have duly performed and complied with all covenants, agreements and
conditions required by this Agreement to be performed or complied with by Purchaser prior to or at the Closing. 
 (c)
Purchaser shall have delivered a certificate executed by a duly authorized officer to Parent to the foregoing effect. 
 7.2 Absence of
Litigation. No order, writ, injunction or decree which is binding on Purchaser, Parent and/or Seller and which prohibits Purchaser, Parent and/or Seller from consummating the transactions contemplated hereby shall be in effect; provided that
Purchaser shall have used its commercially reasonable efforts to have any such order, writ, injunction or decree lifted and the same shall not have been lifted by any such court or governmental or regulatory agency. 
 7.3 Consents and Approvals. All governmental and regulatory approvals requisite or appropriate to the consummation of the transactions
contemplated herein shall have been obtained (or all applicable waiting periods shall have expired) and shall remain in full force and effect. 
 7.4 SWERDA Transaction. Parent, Seller, TDR, Purchaser and SWERDA shall have executed the SWERDA Arrangement, pursuant to which (i) TDR shall sell to SWERDA, and SWERDA shall subsequently leaseback to TDR, the property at
Bude-Stratton Business Park, Bude, Cornwall, EX23 8LY, (ii) SWERDA shall consent to the transactions contemplated hereby, and (iii) SWERDA shall release each of Parent, Seller and TDR from all repayment liabilities and related guaranties.

 7.5 U.S. Employees. Purchaser shall have made offers of employment to three U.S. employees and employment shall have been accepted
in each case in a form that relieves Parent and Seller of all employment obligations to each of such individuals effective upon Closing to the reasonable satisfaction of Parent and Seller. 
 7.6 UK Executives. Parent and Seller shall have been released from any ongoing obligations with respect to severance and employment agreements of
the officers or employees of TDR. 
 7.7 Board Approval. The board of directors of Purchaser shall have approved the execution of this
Agreement and the transactions related thereto. 
  

 10 

 ARTICLE 8 
 CLOSING 
 8.1 Closing. The closing of the transactions contemplated by this Agreement (the
“Closing”) shall take place at the offices of Hogan & Hartson L.L.P., 111 South Calvert Street, Suite 1600, Baltimore, Maryland 21202, on the later of (i) the date of execution hereof and (ii) three (3) Business
Days after satisfaction of the conditions set forth in Articles 6 and 7, or at such other location or later date or time as mutually agreed upon by the parties. The date of the Closing is referred to herein as the “Closing Date.”

 8.2 Deliveries by Parent and Seller. At the Closing, provided all conditions described in Article 7 have been satisfied, Seller
shall execute and deliver to Purchaser the following: 
 (a) a transfer of the Acquired Shares duly executed by the Seller in
favor of the Purchaser together with the relevant share certificate(s) in respect of such Acquired Shares; 
 (b) a copy of
the minutes of a duly held board meeting of TDR at which there are duly passed the resolutions set out and contained in board minutes of TDR in the form attached as Exhibit A; 
 (c) the organizational documents, statutory books (including registers and minute books), common seals (if any) and all books of account
and other records of TDR, complete and (where appropriate) written up to date; 
 (d) the certificate required by
Section 6.1 hereof; 
 (e) such other deeds, bills of sale, endorsements, assignments and other good and sufficient
instruments of conveyance and assignment as the parties and their respective counsel shall deem reasonably necessary or appropriate to vest in Purchaser all right, title and interest in, to and under the Acquired Shares. 
 8.3 Deliveries by Purchaser. At the Closing, (i) the certificate required by Section 7.1 hereof; and (ii) such other instruments or
documents as may be reasonably requested by Parent or Seller to reflect the consummation of the transactions contemplated hereunder. 
 8.4
Cost Reimbursement. Each party shall pay their own costs hereunder, except that a party shall be responsible for the other party’s expenses, to a maximum of £100,000 if a breach by the other party is the principal reason for
failure to close. 
  

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 ARTICLE 9 
 MISCELLANEOUS 
 9.1 Survival of Representations and Warranties. The representations and
warranties contained in Articles 3 and 4 of this Agreement shall survive until the Closing Date but shall expire immediately following closing. The covenants in Article 5 and Section 8.4 shall survive closing. 
 9.2 Publicity. Parent, Seller and Purchaser agree that they will not make any press releases or other announcements with respect to the
transactions contemplated hereby, except as required by applicable law, without the prior approval of the other parties, which approval will not be unreasonably withheld. 
 9.3 Commercially Reasonable Efforts. Each party hereto agrees to use its commercially reasonable efforts to cause the conditions to its obligations hereunder to be satisfied on or prior to the Closing Date and
otherwise to consummate the transactions contemplated by the Agreement. 
 9.4 Further Acts and Assurances. Parent and Seller shall,
at any time and from time to time at and after the Closing, upon request of Purchaser and without additional consideration, take any and all steps reasonably necessary to transfer any assets of the Business that Seller has been unable to assign to
TDR prior to the Closing Date, and Parent and Seller will do, execute, acknowledge and deliver, or will cause to be done, executed, acknowledged and delivered, all such further acts, deeds, assignments, transfers, conveyances and assurances as may
be reasonably required for the more effective transferring and conveying the Acquired Shares to Purchaser. 
 9.5 Notices. Any notice
or other document to be given hereunder by any party hereto to any other party hereto shall be in writing and delivered by courier or by facsimile transmission, receipt confirmed, or sent by any express mail service, postage or fees prepaid,

 If to Parent or Seller: 
 Tripos, Inc. 
 1699 South Hanley Road 
 St. Louis, Missouri 63144 
 Facsimile: (314) 647-8108 
 Attention: John P. McAlister 
 With a copy to:

 Henry D. Kahn, Esq. 
 Hogan & Hartson L.L.P. 
  

 12 

 111 South Calvert Street 
 Baltimore, Maryland 21202 
 Facsimile: (410) 539-6981 
 If to Purchaser: 
 Commonwealth
Biotechnologies, Inc. 
 601 Biotech Drive 
 Richmond, Virginia 23235 
 Facsimile: (804) 915-3831 

			
	Attention:	 	Paul D’Sylva
		 	Richard J. Freer

 With a copy to: 
 Bradley A. Haneberg, Esq. 
 Kaufman & Canoles, P.C. 
 III James Center, 12th Floor 
 1051 East Cary Street 
 Richmond, Virginia 23219 
 Facsimile:
(804) 771-5777 
 or at such other address or number for a party as shall be specified by like notice. Any notice which is delivered in the manner
provided herein shall be deemed to have been duly given to the party to whom it is directed upon actual receipt by such party or its agent. 
 9.6 Construction. This Agreement shall be governed by, and construed and interpreted under, the laws of the state of Delaware, without giving effect to principles of conflicts or choice of law. No provision of this Agreement shall be
construed against or interpreted to the disadvantage of any party hereto by any court or other governmental or judicial authority or by any board of arbitrators by reason of such party or its counsel having or being deemed to have structured or
drafted such provision. All references in this Agreement to Article(s), Section(s), Schedule(s) or Exhibit(s) shall refer to Article(s), Section(s), Schedule(s) or Exhibit(s) of this Agreement. 
 9.7 Knowledge. Whenever used herein with respect to Seller or Parent, the term “knowledge” shall mean the actual knowledge of any of the
persons listed in Schedule 9.7 as of the date hereof. 
 9.8 Attachments. Every Schedule and Exhibit referred to in this
Agreement is incorporated in this Agreement by this reference. The list immediately following the table of contents hereto contains a list of such Schedules and Exhibits. 
  

 13 

 9.9 Parties Bound by Agreement. The terms, conditions and obligations of this Agreement shall
inure to the benefit of and be binding upon the parties hereto and their respective successors and assigns. Except as hereinafter provided, without the prior written consent of the other party, no party hereto may assign such party’s rights,
duties or obligations hereunder or any part thereof to any other Person prior to Closing. No other party is intended to be a third party beneficiary of the covenants between the parties set forth in this Agreement. 
 9.10 Counterparts. This Agreement may be executed in one or more counterparts, each of which shall for all purposes be deemed to be an original
and all of which shall constitute the same instrument. 
 9.11 Headings. The headings of the Articles and Sections of this Agreement
are inserted for convenience only and shall not be deemed to constitute part of this Agreement or to affect the construction hereof. 
 9.12
Modification and Waiver. Any of the terms or conditions of this Agreement may be waived in writing at any time by the party which is entitled to the benefits thereof. No waiver of any of the provisions of this Agreement shall be deemed to or
shall constitute a waiver of any other provision hereof. 
 9.13 Severability. Any provision hereof which is prohibited or
unenforceable in any jurisdiction will, as to such jurisdiction, be ineffective to the extent of such prohibition or unenforceability without invalidating the remaining provisions hereof, and any such prohibition or unenforceability in any
jurisdiction will not invalidate or render unenforceable such provision in any other jurisdiction. To the extent permitted by law, the parties hereto waive any provision of law which renders any such provision prohibited or unenforceable in any
respect. 
 9.14 Access to Records. For a period of six (6) years after the Closing Date, Parent and its attorneys, accountants
and representatives shall, upon reasonable advance notice to Purchaser during normal business hours and without disruption of the business of Purchaser, have reasonable access to all books, accounts, records, documents and information relating to
Parent, Seller, TDR or the Business for any periods prior to the Closing Date in the possession or custody of Purchaser (or Purchaser’s agents) for the purpose of examining and making copies of all or any portion of such documents. In addition,
Parent and its attorneys and representatives shall, upon reasonable advance notice to Purchaser, during normal business hours and without disruption to the business of Purchaser, have reasonable access to employees of the Business with respect to
the defense of any on-going litigation or claim against Parent or Seller. A representative of Purchaser may be present at all times during such access and investigation by Parent or its attorneys, accountants and representatives. 
 9.15 Entire Agreement. This Agreement and the Schedules and Exhibits hereto, together with the documents and instruments delivered pursuant
hereto, constitute the entire agreement between the parties hereto pertaining to the subject matter hereof and supersede all prior and contemporaneous agreements, understandings, negotiations and discussions, whether written or oral, of the parties
hereto; provided, however, that this provision is not intended to 

  

 14 

 
abrogate any other written agreement between the parties executed with or after this Agreement or any written agreement pertaining to another subject matter.
No supplement, modification or waiver of the terms or conditions of this Agreement shall be binding unless executed in writing by authorized representatives of the parties hereto. 
 9.16 Certain Definitions. 
 (a) “Business Days” means a day other than a Saturday, Sunday, bank or public holiday in the United Kingdom. 
 (b) “Encumbrance” means any lien, security interest, pledge, agreement, claim, charge or encumbrance. 
 (c) “Governmental Entity” means any governmental or regulatory authority, domestic or foreign. 
 (d)
“Intellectual Property” shall mean patents, rights to inventions, utility models, copyrights, trade marks, service marks, trade, business and domain names, rights in trade dress or get-up, rights in goodwill or to sue for passing off,
unfair competition rights, rights in designs, rights in computer software, database rights, topography rights, moral rights, rights in confidential information (including know-how and trade secrets) and any other intellectual property rights, in
each case whether registered or unregistered and including all applications for and renewals or extensions of such rights, and all similar or equivalent rights or forms of protection in any part of the world. 
 (e) “Person” means any individual, corporation (including not-for-profit), general or limited partnership, limited liability
company, joint venture, estate, trust, association, organization, Governmental Entity or other entity of any kind or nature. 
 (f) “UBCA” means the Utah Revised Business Corporation Act, as amended. 
  

 15 

 IN WITNESS WHEREOF, the parties hereto have caused this Amended and Restated Agreement to be duly
executed and delivered, all on and as of the date first written above. 
  

					
	TRIPOS, INC.	 	
			
	By:	 	 /s/ John P. McAlister
	 	
	Name:	 	John P. McAlister	 	
	Title:	 	President and CEO	 	
		
	TRIPOS UK HOLDINGS LIMITED	 	
			
	By:	 	 /s/ John P. McAlister
	 	
	Name:	 	John P. McAlister	 	
	Title:	 	Director	 	
		
	COMMONWEALTH BIOTECHNOLOGIES, INC.	 	
			
	By:	 	 /s/ Paul D’Sylva
	 	
	Name:	 	Paul D’Sylva	 	
	Title:	 	CEO

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