Document:

Exhibit 10.10

 

AMENDMENT NO.3 TO CONSULTING AGREEMENT

 

This Amendment No.
3 to Consulting Agreement (this “Amendment”), dated _June 30, __________, 2016, is entered into between PhaseRx,
Inc., a Delaware corporation having a place of business at 410 West Harrison Street, Seattle, WA 98119 (the “Company”)
and Paul H. Johnson, Ph.D., having a place of business at 12020 211th Place SE, Snohomish, Washington 98296 (the “Consultant”).

 

RECITALS

 

WHEREAS, the Consultant
and the Company entered into a Consulting Agreement, effective as of July 2, 2013, as previously amended by that certain Amendment
to the Consulting Agreement, effective as of January 2, 2014, and Amendment No.2 to Consulting Agreement, dated as of February
10, 2016 (as so amended, the “Agreement”);

 

WHEREAS, the Company
and the Consultant desire to amend the Agreement to reduce the consultant fees set forth on Exhibit A attached thereto.

 

NOW, THEREFORE, in
consideration of the mutual promises and covenants set forth herein, the parties hereto, intending legally to be bound, hereby
agree as follows:

 

		1.	Definitions

 

Unless the
context clearly requires otherwise, all capitalized terms as used herein shall have the same meanings as used in the Agreement.

 

		2.	Amendment Date

 

This Amendment
shall be effective as of the date hereof.

 

		3.	Amendments to Agreement

 

The parties agree that
the first bullet under “2. Compensation” on Exhibit A to the Agreement shall be deleted in its entirety and replaced
with the following:

 

“• $5,000 in cash per year, paid in equal
quarterly installments in arrears.”

 

		4.	No Other Waivers or Modifications; Applicability of
this Agreement

 

Except to
the extent expressly modified by Section 3 of this Amendment, no other covenant, term, provision, condition or agreement of the
parties set forth in the Agreement shall be deemed to be waived, modified or amended in any way by this Amendment. All of the recitals,
covenants, terms, provisions, conditions and agreements of the parties set forth in the Agreement shall be deemed applicable to
this Amendment.

 

		5.	Entire Agreement

 

The Agreement, as modified
by this Amendment, constitute the entire agreement between the parties, and supersedes all prior or written agreements, commitments
or understandings concerning the matters provided for herein.

 

     

     

    

 

		6.	Counterparts

 

This Amendment may be
executed in any number of counterparts, all of which taken together shall constitute one and the same agreement, and any of the
parties hereto may execute this Amendment by signing any such counterpart. Delivery of an executed counterpart of a signature page
to this Amendment by telecopier or by electronic mail (in portable document format (“PDF”)) shall be effective as delivery
of a manually executed counterpart of this Amendment.

 

[Signature page follows]

 

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IN WITNESS
WHEREOF, the parties have
executed this Amendment as of the
date and year first written above.

 

	COMPANY:	CONSULTANT
	 	 
	PHASERX, INC.	/S/Paul Johnson
	a Delaware corporation	Paul H. Johnson, Ph.D.

 

	By:	/S/ Shing-Yin (Helen) Tsui	 
	Name: Shing-Yin Tsui	 
	Title: VP, FinanceExhibit

Exhibit 10.3

MARKEL CORPORATION
    
PERFORMANCE-BASED RESTRICTED STOCK UNIT
AWARD AGREEMENT

	
				
	

AWARDED TO
	

AWARD DATE
	

VESTING SCHEDULE1

	 
	

For example: February XX, 2017
	VESTING 
DATE 
12/31/2020 
	PERCENTAGE OF UNITS
100%

MARKEL CORPORATION (the "Company") grants you (the "Participant") the opportunity to receive restricted stock units ("Units"). The number of Units will be based on performance conditions as specified below. Until the Vesting Date, except as specifically provided below, the Units are forfeitable and nontransferable. The Compensation Committee of the Company's Board of Directors (the "Committee") will administer this Agreement and any decision of the Committee will be final and conclusive.  Capitalized terms not defined herein have the meanings provided in the Markel Corporation 2016 Equity Incentive Compensation Plan (the "Plan").  

The terms of the award are:

		
	1.
	Performance Conditions:  The performance conditions are set forth on Exhibit A. Upon certification by the Committee of the completion of the performance conditions, the dollar equivalent of the percentage of salary will be determined.  The Participant will receive a number of Units determined by dividing the dollar equivalent by the Fair Market Value of a share of Company Stock on the date that the completion of the performance conditions is certified by the Committee or its designee (the "Determination Date"). No Units will be awarded hereunder if the Participant separates from service for any reason before the Determination Date. 

		
	2.
	Vesting For Units. If the Participant has not separated from service before the Vesting Date, the Units will become vested and non-forfeitable, and the Company will issue to the Participant for each vested Unit a share of Company Stock on that date (or such later date as may be elected by the Participant pursuant to a valid deferral election in accordance with procedures determined

1 If necessary or appropriate to ensure orderly administration of the Company’s payroll and tax reporting obligations, the Company may accelerate vesting and payment of restricted stock units up to a maximum of thirty days before the date on which such restricted stock units would otherwise have vested and been paid.

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	by the Company) or, in either case, as soon as administratively practicable (but in any event no later than 90 days) thereafter.

		
	3.
	Forfeiture of Units.  If the Participant separates from service before the Vesting Date in circumstances other than as described in (a)-(d) below, any unvested Units will be forfeited. If the Participant separates from service due to Retirement, death or Disability before the Vesting Date as set forth in (a) below, the unvested Units will become fully vested and non-forfeitable, and shares will be issued on the date on which the Participant's Retirement, death or Disability occurs or as soon as administratively practicable (but in any event no later than 90 days) thereafter, subject in the case of the Participant's Retirement to Section 5 below.  If the Participant separates from service before the Vesting Date in the circumstances set forth in (b) or (c) below, the number of Units set forth in this Award will be vested on a pro rata basis based on a fraction of the number of whole months from January 1 of the calendar year following the calendar year in which the Award Date occurs until the date of termination divided by 36, and shares will be issued on the otherwise applicable Vesting Date, subject to Section 5 below.  Any remaining unvested Units will be forfeited as of the date of separation; except that a Participant who separates from service or whose employment is interrupted due to military service as provided in (c) below and who returns to employment with the Company upon cessation of such military service before the otherwise applicable Vesting Date will vest in any remaining unvested Units if employed on the Vesting Date.  If the Participant separates from service before the Vesting Date in the circumstance set forth in (d) below, the unvested Units will become fully vested and non-forfeitable, and shares will be issued on the otherwise applicable Vesting Date, subject to Section 5 below. 

		
	(a)
	The Participant separates from service due to Retirement, death or Disability; 

		
	(b)
	The Participant separates from service due to Early Retirement;

		
	(c)
	The Participant separates from service or his employment is interrupted due to military service; or

		
	(d)
	Neither (a), (b) nor (c) applies, but the Committee determines that forfeiture should not occur because the Participant had an approved separation from service.  The Committee will in its sole discretion determine whether or not to apply this provision.

    
		
	4.
	Change in Control.  Any unvested Units will become fully vested and non-forfeitable if, within 12 months after a Change in Control, the Participant separates from service due to Involuntary Termination. For this purpose, Involuntary Termination means that the Participant's employment is involuntarily terminated without Cause or the Participant terminates his employment for Good Reason.  In either case, shares will be issued for such Units on the otherwise applicable Vesting Date, subject to Section 5 below.   

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	5.
	Six Month Delay for Specified Employees.  With respect to a Participant who separates from service due to Retirement before the Vesting Date as set forth in Section 3(a) above, or who separates from service before the Vesting Date as set forth in Sections 3(b), (c) or (d) above or in Section 4, if such Participant is a "specified employee" (as defined in Section 409A(a)(2)(B)(i) of the Code and the generally applicable Internal Revenue Service guidance thereunder) on the date of his separation, then, notwithstanding anything in Sections 3 or 4 to the contrary, no shares will be issued for his Units until the date that is six months after the date of his separation (or until the date of his death, if earlier).  Any shares which the Participant would otherwise have been entitled to receive during the first six months following the date of his separation will be issued instead on the date which is six months after the date of his separation (or on the date of his death, if earlier).  Whether the Participant is a "specified employee" will be determined under guidelines established by the Company for this purpose.

		
	6.
	Separation from Service Defined.  References throughout this Agreement to the Participant's "separation from service" and variations thereof will have the meaning set forth in Section 1.409A-1(h) of the Treasury Regulations, as amended from time to time, applying the default terms thereof.

		
	7.
	Forfeiture and Restitution. If during the period of the Participant's employment and two years thereafter, the Participant (1) becomes associated with, recruits or solicits customers or other employees of the Employer for, is employed by, renders services to, or owns any interest in (other than any non-substantial interest, as determined by the Committee) any business that is in competition with Markel or its Subsidiaries, (2) has his employment terminated by his Employer for Cause, or (3) engages in, or has engaged in, conduct which the Committee determines to be detrimental to the interests of Markel, the Committee may, in its sole discretion, (A) cancel this Award, and/or (B) require the Participant to repay by delivery of an equivalent number of shares any payment received under this Award within the previous two years. In addition, this Award shall be subject to any recoupment or clawback policy that is adopted by, or applicable to, the Company, pursuant to any requirement of law or any exchange listing requirement related to clawback or other recovery of incentive compensation. 

 
		
	8.
	Transfer Restrictions.  The Participant's rights to the Units are not subject to sale, assignment, transfer, pledge, hypothecation or encumbrance.

		
	9.
	Tax Withholding.  Unless alternative arrangements satisfactory to the Company are made, the Company will withhold from the payment for the vested Units shares with a Fair Market Value equal to the minimum amount of any foreign, federal, state, or local income, employment or other taxes imposed on the payment required to be withheld by law. The Fair Market Value will be determined on the Vesting Date. 

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	10.
	Binding Effect.  Subject to the limitations stated above, this Agreement will be binding upon and inure to the benefit of the Participant's legatees, distributees, and personal representatives and the successors of the Company.

		
	11.
	Change in Capital Structure.  The Units will be adjusted as the Committee determines is equitably required in the event of a dividend in the form of stock, spin-off, stock split-up, subdivision or consolidation of shares of Company Stock or other similar changes in capitalization.

		
	12.
	Interpretation.  This Agreement will be construed under and be governed by the laws of the Commonwealth of Virginia.  THE UNITED STATES DISTRICT COURT FOR THE EASTERN DISTRICT OF VIRGINIA OR THE CIRCUIT COURT FOR THE COUNTY OF HENRICO WILL HAVE EXCLUSIVE JURISDICTION OVER ANY DISPUTES ARISING OUT OF OR RELATED TO THE PLAN OR THIS AGREEMENT.

		
	13.
	Code Section 409A.  This Agreement is intended to comply with the applicable requirements of Sections 409A(a)(2) through (4) of the Code, and will be interpreted to the extent context reasonably permits in accordance with this intent.  The parties agree to modify this Agreement or the timing (but not the amount) of any payment to the extent necessary to comply with Section 409A of the Code and avoid application of any taxes, penalties, or interest thereunder.  However, in the event that any amounts payable under this Agreement are subject to any taxes, penalties or interest under Section 409A of the Code or otherwise, the Participant will be solely liable for the payment thereof.  

		
	14.
	By accepting any benefits under this Agreement, Participant is accepting all the provisions hereof, including without limitation Section 7 hereof.

IN WITNESS WHEREOF, the Company has caused this Agreement to be signed as of the award date shown above.

	
			
	 
	 
	MARKEL CORPORATION

	 
	 
	 

	 
	 
	By: _____________________________

	 
	 
	Authorized Officer

	 
	 
	 

	 
	 
	 

	 
	 
	 

	 
	 
	 

	 
	 
	 

	 
	 
	 

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