Document:

2012 Corporate Bonus Plan

 Exhibit 10.11 
 CADENCE PHARMACEUTICALS, INC. 
 BONUS PLAN 

Effective January 1, 2012 
 INTRODUCTION AND PURPOSE 
 The Cadence Pharmaceuticals, Inc.
(“Cadence” or the “Company”) Bonus Plan (the “Plan”) is designed to reward eligible employees for the achievement of corporate objectives, as well as measured individual objectives that are consistent with and support
the overall corporate objectives. Since cooperation between departments and employees will be required to achieve corporate objectives that represent a significant portion of the Plan, the Plan should help foster teamwork and build a cohesive
management team. 
 The Plan is designed to: 
  

	 	•	 	 Encourage high performance by providing an incentive program to achieve overall corporate objectives and to enhance shareholder value.

  

	 	•	 	 Reward those individuals who significantly impact corporate results. 

 

	 	•	 	 Encourage increased teamwork among all disciplines within Cadence. 

 

	 	•	 	 Incorporate an incentive program in the Cadence overall compensation program to help attract and retain employees. 

 

	 	•	 	 Provide an incentive for eligible employees to remain employed by Cadence through and beyond the payout of any earned bonus.

 ELIGIBILITY 
 All regular employees are eligible to participate in the Plan. Employees are not eligible if included in a separate formal incentive plan provided by the Company. In order to be eligible, a participant
must have been in an eligible position for at least three (3) full consecutive months prior to the end of the Plan year, and the participant must remain employed through the end of the Plan year and until awards are paid. If the participant is
not employed on the date awards are paid, the participant will not have earned any bonus. If the participant has been subject to a performance improvement plan or other disciplinary procedure during the Plan year, any award to such individual will
be at the discretion of the President and CEO or the Compensation Committee. 
 Change in Status During the Plan Period:

  

	 	a.	Participants hired during the Plan year: 

  

	 	•	 	 Participants hired during the Plan year are eligible for a prorated award based on the number of months employed in an eligible position.

  

	 	•	 	 Participants hired after the end of the third quarter are not eligible to participate for the plan year. 

 

	 	b.	Promotion/change in level:  

  

	 	•	 	 For promotions that occur after April 30th of the applicable Plan year but prior to October 1st of the applicable Plan year, the calculation will be prorated, based on the number of months at each bonus percentage
level. 

  

	 	•	 	 If the promotion occurred on or after October 1st of the applicable Plan year, the entire calculation will be based on the bonus percentage applicable prior to the
promotion. 

  

	 	c.	Transfer to a position that is included in a separate formal Incentive Plan: Awards will be pro-rated using the same discipline as outlined for promotions above
and in the formal Incentive Plan. 

  
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	 	d.	Termination of employment:  

  

	 	•	 	 If a participant’s employment is terminated voluntarily prior to the date awards are paid, the participant will not be eligible to receive an
award. 

  

	 	•	 	 If a participant’s employment is terminated involuntarily prior to the date awards are paid, it will be at the absolute discretion of the Company
whether or not an award payment is made. 

  

	 	e.	Leave of Absence: Employee may be considered for a prorated award. 

 AWARD CALCULATION 
 Awards will be determined by applying a
“bonus percentage” to the participant’s base salary in effect at the end of the Plan year. While the Compensation Committee may change the bonus percentage for any Plan year, the following bonus percentages will initially be used for
this purpose: 
  

					
	 Position Title
	  	Bonus Percentage	 
	 President/CEO
	  	 	75	% 
	 EVP, SVP
	  	 	40	% 
	 VP
	  	 	30	% 
	 Executive Director, Senior Director
	  	 	25	% 
	 Director
	  	 	20	% 
	 Medical Science Liaison
	  	 	15	% 
	 Associate Director, Senior Manager
	  	 	15	% 
	 Manager
	  	 	10	% 
	 Analyst/Specialist
	  	 	8	% 
	 Administrative/Accounting Associate
	  	 	6	% 

 Corporate and Individual Performance Factors 

The President and/or CEO will present to the Compensation Committee a list of the overall corporate objectives for the applicable Plan
year, which are subject to approval by the Compensation Committee. All participants in the Plan will then develop a list of key individual objectives, which must be approved by the responsible Vice President or Senior Vice President and, in the case
of executive officers, by the President and/or CEO. 
 The relative weight between corporate and individual performance factors
varies based on the individual’s assigned level within the organization. The weighting may be reviewed periodically and may be adjusted for any Plan year. The weighting for the performance factors will initially be as follows: 

 

									
	  	  	Corporate	 	 	Individual	 
	 President/CEO
	  	 	100	% 	 			
	 EVP/SVP
	  	 	75	% 	 	 	25	% 
	 VP
	  	 	60	% 	 	 	40	% 
	 Exec Dir/Sr Dir/Dir/Assoc Dir/Sr Mgr/MSL
	  	 	50	% 	 	 	50	% 
	 Manager
	  	 	40	% 	 	 	60	% 
	 Analyst/Specialist/Administrative
	  	 	30	% 	 	 	70	% 

 Performance Award Multiplier 

Separate award multipliers will be established for both the corporate and the individual components of each award. The award multiplier
for the corporate component shall be determined by the Compensation Committee each Plan year, in its sole discretion. The same award multiplier for the corporate component of the award shall be used for all Plan participants. The award multiplier
for the individual component shall be determined by the responsible Vice President or Senior Vice President and by the President and/or CEO. 

  
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 While the Compensation Committee may change the award multipliers for any Plan year, the
following scale will be used to determine the actual performance award multiplier based upon the measurement of corporate and individual performance objectives. 
  

					
	 	  	 Performance Category
	  	Award Multiplier
	 1.
	  	 Performance for the year met or exceeded objectives or was excellent in view of prevailing
conditions
	  	75% - 150%
	 2.
	  	 Performance generally met the year’s objectives or was very acceptable in view of
prevailing conditions
	  	50% - 100%
	 3.
	  	 Performance for the year met some, but not all, objectives
	  	25% -50%
	 4.
	  	 Performance for the year was not acceptable in view of prevailing conditions
	  	0%

 Example 
 The example below shows a sample cash bonus award calculation under the Plan, which is determined after the end of the performance period. 

Step #1: A potential base bonus award is calculated by multiplying the employee’s base salary by their assigned level
bonus percentage. 
 Step #2: The calculated potential base bonus amount is then split between the corporate and
individual performance factors by the employee’s assigned level (per the weighting above). This calculation establishes specific potential dollar awards for the performance period based on both the individual and corporate performance factor
components. 
 Step #3: After the end of the performance period, corporate and individual award multipliers will
be established using the criteria described above. Awards are determined by multiplying the potential bonus awards in Step #2 by the actual corporate and individual award multipliers. 

 

							
	 Example:
	  	 Step # 1: Potential Bonus Award Calculation
	 	
		  	 Position:
	 	Director	 	
		  	 Base salary:
	 	$100,000	 	
		  	 Target bonus percentage:
	 	        20%	 	
		  	 Potential base bonus:
	 	$20,000	 	
		
	 Step # 2:
	  	Split award target amount based on weighting of Performance Factors
		  	 Potential corporate performance bonus (50%):
	 	$10,000	 	
		  	 Potential individual performance bonus (50%):
	 	$10,000	 	
				
	 Step # 3:
	  	 Actual Cash Incentive Award Calculation
	 		 	
	
	 Assumed payment multipliers based on assessment of corporate and individual performance:

		  	 Corporate multiplier
	 	75%-performance generally met objectives
		  	 Individual multiplier
	 	125%-performance generally exceeded objectives
		  	 Cash Award:
	 		 	
		  	 Corporate component
	 	$  7,500	 	($10,000 x 75%)
		  	 Individual component
	 	$12,500	 	($10,000 x 125%)
		  	 Total Award
	 	$20,000	 	

  
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 AWARD PAYMENTS 

Bonus award payments may be made in cash, through the issuance of stock, stock options or another form of equity award, or by a
combination of cash, stock, stock options and/or another form of equity award, at the discretion of the Compensation Committee. All bonus award payments are subject to applicable tax withholdings. In the event that the Compensation Committee and/or
the Board of Directors elect to pay bonus awards in stock or stock options, the Compensation Committee, in its sole discretion, will make a determination as to the number of shares of stock or stock options to be issued to each Plan participant
based, in part, upon the overall corporate performance and each participant’s individual performance, as described. The issuance of stock and stock options may also be subject to the approval of the Company’s stockholders, and any stock
options issued will be subject to the terms and conditions of the Company’s Equity Incentive Award Plan, as amended from time to time by the Company. 
 Payment of bonus awards will be made as soon as practicable after the issuance of the Company’s year-end audited Financial Statements for the Plan year, but not later than December 31 of the
year following the Plan year. Payments will not be impacted by any benefits, with the exception of elected 401(k) contributions which will be applied. 
 PLAN PROVISIONS 
 Governance 

The Plan will be governed by the Compensation Committee of the Board of Directors (the “Compensation Committee”). The President
and/or CEO of Cadence will be responsible for the administration of the Plan. The Compensation Committee will be responsible for approving any compensation or incentive awards to officers of the Company. All determinations of the Compensation
Committee, under the Plan, shall be final and binding on all Plan participants. 
 Compensation Committee’s Absolute
Right to Alter or Abolish the Plan 
 The Compensation Committee reserves the right in its absolute discretion to abolish the
Plan at any time or to alter the terms and conditions under which incentive compensation will be paid. Such discretion may be exercised any time before, during, and after the Plan year is completed. No participant shall have any vested right to
receive any compensation hereunder until actual delivery of such compensation. Participation in the Plan at any given time does not guarantee ongoing participation. 
 Employment Duration/Employment Relationship 
 This Plan does not, and
Cadence’s policies and practices in administering this Plan do not, constitute an express or implied contract or other agreement concerning the duration of any participant’s employment with the Company. The employment relationship of each
participant is “at will” and may be terminated at any time by Cadence or by the participant, with or without cause. 
 Any
questions pertaining to this plan should be directed to the Human Resources Department. 

  
 4First Amendment to Lease

 Exhibit 10.16 
 FIRST AMENDMENT TO LEASE 
 (High Bluff Ridge) 

THIS FIRST AMENDMENT TO LEASE (this “First Amendment”) is made and entered into as of September 29, 2006 by
and between PRENTISS/COLLINS DEL MAR HEIGHTS LLC, a Delaware limited liability company, as tenants in common (“Landlord”), and CADENCE PHARMACEUTICALS, INC., a Delaware corporation (“Tenant”).

 R E C I T A L S: 

A. Landlord and Tenant entered into that certain Office Lease dated as of May 12, 2006 (the “Lease”).
Capitalized terms used herein without definition shall have the meanings set forth for such terms in the Lease. 
 B. Pursuant
to, and as more particularly described in the Lease, Landlord leases to Tenant certain space in a building located at 12481-12531 High Bluff Drive, City of San Diego, County of San Diego, State of California. 

B. Landlord and Tenant now desire to amend the Lease to reduce the unreserved, uncovered parking privileges provided to Tenant under the
Lease, subject to the terms and conditions set forth herein. 
 A G R E E M E
N T: 
 NOW, THEREFORE, in consideration of the mutual covenants and agreements herein contained and for other
good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant hereby agree as follows: 
 1. Amendment. Section 1.16 of the Lease is amended and restated in its entirety to read as follows: 
  

	“1.16	Parking: A total of ninety-eight (98) parking privileges at the 12481 Building, which shall be comprised of (i) a minimum. of seventy-one
(71) unreserved; uncovered parking privileges at no additional cost to Tenant, and (ii) a maximum of twenty-seven (27) reserved, covered parking privileges at an additional cost to Tenant of $100 per stall per month. All such parking
privileges shall be subject to the provisions set forth in Section 6.2 of this Lease.” 

 (a)
Miscellaneous. This First Amendment embodies the entire understanding between Landlord and Tenant with respect to its subject matter and can be changed only by an instrument in writing signed by Landlord and Tenant. This First
Amendment may be executed in counterparts, including facsimile counterparts, each of which shall be deemed an original, but all of which, together, shall constitute one and the same First Amendment. Each individual executing this First Amendment
that he or she is duly authorized to execute and deliver this First Amendment. Landlord and Tenant each hereby acknowledges and reaffirms all of its obligations under the Lease, as such Lease has been amended by this First Amendment, and agrees that
any reference made in any other document to the Lease shall mean the Lease as amended pursuant to this First Amendment. Except as expressly provided herein, the Lease remains, unmodified and in full force and effect. The Lease shall remain in full
force and effect and binding upon the parties hereto except as otherwise addressed herein. 

 IN WITNESS WHEREOF, the parties have executed this Amendment as of the date and year first
set forth above. 
 LANDLORD: 
 PRENTISS/COLLINS DEL MAR HEIGHTS LLC, 
 a Delaware limited liability
company, 
  

			
	By:	  	 The Prudential Insurance Company of America,
 a New Jersey Corporation
 Its sole member

  

					
	 By:
	  		 	 /s/ Darin Bright

		  		 	Darin Bright, Vice President

 TENANT: 
 CADENCE PHARMACEUTICALS, INC., 
 a Delaware corporation 

 

			
	By:	 	 /s/ William R. LaRue

	Name:	 	 William R. LaRue

	Title:	 	 SVP-CFO

  
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