Document:

Exhibit 10.30

FIRST AMENDMENT

to

LEASE BETWEEN

E S EAST, LLC (LANDLORD)

And

KINEMED, INC. (TENANT)

 

That certain Lease with an Effective Date
of October 20, 2012 made by and between E S East, LLC as Landlord and KineMed, Inc., as Tenant (the “Original Lease”)
is hereby amended by the terms of this First Amendment (the “First Amendment”). The effective date of this First Amendment
shall be July 1, 2012 (the “First Amendment Effective Date”). Effective upon the First Amendment Effective Date, the
Original Lease and this First Amendment thereto shall together constitute and be referred to as the “Lease” for all
purposes thereunder.

 

		I.	Landlord and Tenant hereby agree to extend the expiry of the Lease Term by twelve (12) months to
become July 31, 2013, said twelve-month period from August 31, 2012 through July 31, 2013 to be referred to as the “Extension
Term”.

 

		II.	Monthly Base Rent during the Extension Term shall be as follows:

August 1, 2012 - January 31, 2013:
$6,050.00

February 1, 2013 - July 31, 2013:
   $9,501.25

 

		III.	Tenant shall pay its Pro-Rata Share of all operating expenses and taxes during the Extension Term
based on the full 3,455 rentable square footage of the Premises.

 

		IV.	Tenant hereby represents to Landlord that it has been represented by Jonathan Tomasco of Cornish
& Carey in this transaction and that no brokerage commission will be payable to any other tenant broker or representative as
a result hereof.

 

		V.	Except for those terms outlined herein, all other terms and conditions of the Lease shall apply.

 

In witness hereof, the parties have executed
this First Amendment.

 

	TENANT:	 	LANDLORD:
	 	 	 
	KineMed, Inc., a Delaware Corporation.	 	E S East, LLC, a 
	 	 	California Limited Liability Company

 

	By: 	/s/ David M. Fineman	 	By: 	/s/ Richard K. Robbins

 

	Print Name: 	David M. Fineman	 	Print Name: 	Richard K. Robbins

 

	Its: 	Chairman & CEO	 	Its: 	Managing Member

 

	Dated: 7/16/12	 	Dated:Exhibit 10.31

 

SECOND AMENDMENT to LEASE BETWEEN

E S EAST, LLC (LANDLORD) and KINEMED, INC.
(TENANT)

 

That certain Lease with an Effective Date of October 20, 2012
made by and between E S East, LLC as Landlord and KineMed, Inc., as Tenant (the “Original Lease”), as such was amended
via First Amendment with an Effective Date of July 1, 2012 (the “First Amendment”), is hereby amended by the terms
of this Second Amendment (the “Second Amendment”). The effective date of this Second Amendment shall be June 15, 2013
(the “Second Amendment Effective Date”). Effective upon the Second Amendment Effective Date, the Original Lease, First
Amendment and this Second Amendment shall together constitute and be referred to as the “Lease” for all purposes thereunder.

 

		I.	Landlord and Tenant hereby agree to extend the expiry of the Lease Term by fifty (50) months to
become September 30, 2017 (the “Extended Lease Term”).

 

		II.	Up to and including July 31, 2013, Monthly Base Rent shall be as called for in the First Amendment.
Effective August 1, 2013, Monthly Base Rent shall be as follows:

  

	PERIOD	 	MONTHLY BASE RENT	 
	 	 	 	 
	8/1/13 - 8/31/13	 	$	0.00	 
	9/1/13 - 7/31/14	 	$	9,674.00	 
	8/1/14 - 7/31/15	 	$	9,964.22	 
	8/1/15 - 8/31/15	 	$	0.00	 
	9/1/15 - 7/31/16	 	$	10,263.15	 
	8/1/16 - 7/31/17	 	$	10,571.04	 
	8/1/17 - 7/31/17	 	$	10,888.17	 
	8/1/17 - 9/30/17	 	$	11,214.82	 

  

		III.	Tenant shall pay its Pro-Rata Share of all operating expenses and taxes during the existing and
Extended Lease Term based on the full 3,455 rentable square footage of the Premises.

 

		IV.	Article 21 of the Lease regarding Landlord's relocation rights shall be revised such that Landlord
shall be requires to give Tenant one hundred eighty (180) days advance notice of any such relocation. As stated in Article 21 of
the Lease, qualifying relocation properties shall be limited to the City of Emeryville.

 

		V.	Promptly following the mutual execution of this Second Amendment, Landlord shall, at its sole cost
and expense, make the following improvements to Tenant's Premises: Increase the size of the three maintenance access ports in the
cage wash area pursuant to the drawing attached hereto as Exhibit A.

 

		VI.	Tenant hereby represents to Landlord that it has been represented by Jonathan Tomasco of Cornish
& Carey in this transaction and that no brokerage commission will be payable to any other tenant broker or representative as
a result hereof.

 

		VII.	Except for those terms outlined herein, all other terms and conditions of the Lease shall apply.

  

    	 

    	 

    

 

In witness hereof, the parties have executed this Second Amendment.

 

	TENANT:	 	LANDLORD:
	 	 	 
	KineMed, Inc., a Delaware Corporation.	 	E S East, LLC, a California Limited Liability Company
	 	 	 
	By: 	/s/ David M. Fineman	   	By:	/s/ Richard K. Robbins
	 	 	 
	Print Name: 	David Fineman	 	Print Name:	Richard K. Robbins
	 	 	 
	Its:	Pres & CEO	 	Its: 	Managing Member
	 	6/13/2013	 	 	 

 

    	 

    	 

    

 

 

EXHIBIT AExhibit 10.33

 

Lock-Up Agreement

 

___, 2013

Aegis Capital Corp.

810 Seventh Avenue, 18th Floor

New York, New York 10019

 

Ladies and Gentlemen:

 

The undersigned understands
that Aegis Capital Corp. (the “Representative”) proposes to enter into an Underwriting Agreement (the “Underwriting
Agreement”) with KineMed, Inc., a (the “Company”), providing for the public offering (the “Public
Offering”) of shares of common stock, par value $0.001 per share, of the Company (the “Shares”).

 

To induce the Representative
to continue its efforts in connection with the Public Offering, the undersigned hereby agrees that, without the prior written consent
of the Representative, the undersigned will not, during the period commencing on the date hereof and ending 180 days after the
date of the final prospectus relating to the Public Offering (the “Lock-Up Period”), (1) offer, pledge, sell,
contract to sell, grant, lend, or otherwise transfer or dispose of, directly or indirectly, any Shares or any securities convertible
into or exercisable or exchangeable for Shares, whether now owned or hereafter acquired by the undersigned or with respect to which
the undersigned has or hereafter acquires the power of disposition, owned directly by the undersigned (including holding as a custodian)
or with respect to which the undersigned has beneficial ownership within the rules and regulations of the Securities and Exchange
Commission (collectively, the “Lock-Up Securities”); (2) enter into any swap or other arrangement that transfers
to another, in whole or in part, any of the economic consequences of ownership of the Lock-Up Securities, whether any such transaction
described in clause (1) or (2) above is to be settled by delivery of Lock-Up Securities, in cash or otherwise; (3) make any demand
for or exercise any right with respect to the registration of any Lock-Up Securities; or (4) publicly disclose the intention to
make any offer, sale, pledge or disposition, or to enter into any transaction, swap, hedge or other arrangement relating to any
Lock-Up Securities. The foregoing restriction is expressly agreed to preclude the undersigned from engaging in any hedging or other
transaction which is designed to or which reasonably could be expected to lead to or result in a sale or disposition of the Lock-Up
Securities even if such Lock-Up Securities would be disposed of by someone other than the undersigned. Such prohibited hedging
or other transactions would include without limitation any short sale or any purchase, sale or grant of any right (including without
limitation any put or call option) with respect to any of the Lock-Up Securities or with respect to any security that includes,
relates to, or derives any significant part of its value from such Lock-Up Securities.

 

Notwithstanding the
foregoing, and subject to the conditions below, the undersigned may transfer Lock-Up Securities without the prior written consent
of the Representative in connection with (a) transactions relating to Lock-Up Securities acquired in open market transactions after
the completion of the Public Offering; provided that no filing under Section 16(a) of the Securities Exchange
Act of 1934, as amended (the “Exchange Act”), shall be required or shall be voluntarily made in connection with
subsequent sales of Lock-Up Securities acquired in such open market transactions; (b) transfers of Lock-Up Securities as a bona
fide gift, by will or intestacy or to a family member or trust for the benefit of a family member (for purposes of this lock-up
agreement, “family member” means any relationship by blood, marriage or adoption, not more remote than first cousin);
(c) transfers of Lock-Up Securities to a charity or educational institution or (d) if the undersigned, directly or indirectly,
controls a corporation, partnership, limited liability company or other business entity, any transfers of Lock-Up Securities to
any shareholder, partner or member of, or owner of similar equity interests in, the undersigned, as the case may be; provided
that (i) in the case of any transfer pursuant to the foregoing clauses (b), (c) or (d), any such transfer shall not involve
a disposition for value and each transferee shall sign and deliver to the Representative a lock-up agreement substantially in the
form of this lock-up agreement and (ii) in the case of any transfer pursuant to the foregoing clauses (c) or (d), no filings
under Section 16(a) of the Exchange Act shall be required or shall voluntarily be made, provided that any filing under Section
16(a) of the Exchange Act in connection with a transfer pursuant to the foregoing clause (b) must indicate by footnote the nature
of such transfer within the terms of such clause (b). The undersigned also agrees and consents to the entry of stop transfer instructions
with the Company’s transfer agent and registrar against the transfer of the undersigned’s Lock-Up Securities except
in compliance with this lock-up agreement.

 

    	 

    	 

    

 

If the undersigned
is an officer or director of the Company, the undersigned agrees that the foregoing restrictions shall be equally applicable to
any issuer-directed or “friends and family” Shares that the undersigned may purchase in the Public Offering.

 

Furthermore, if the
undersigned is an officer or director of the Company, the Representative agrees that, at least three (3) business days before the
effective date of any release or waiver of the foregoing restrictions in connection with a transfer of Lock-Up Securities by the
undersigned, the Representative will notify the Company of the impending release or waiver, and the Company has agreed in the Underwriting
Agreement to announce the impending release or waiver by press release through a major news service at least two (2) business days
before the effective date of the release or waiver. Any release or waiver granted by the Representative hereunder to any such officer
or director shall only be effective two (2) business days after the publication date of such press release. The provisions of this
paragraph will not apply if (a) the release or waiver is effected solely to permit a transfer of Lock-Up Securities not for consideration
and (b) the transferee has agreed in writing to be bound by the same terms described in this lock-up agreement to the extent and
for the duration that such terms remain in effect at the time of such transfer.

 

No provision in this
agreement shall be deemed to restrict or prohibit the exercise, exchange or conversion by the undersigned of any securities exercisable
or exchangeable for or convertible into Shares, as applicable, including, for the avoidance of doubt, stock options, convertible
promissory notes and warrants; provided that the undersigned does not transfer the Shares acquired on such exercise, exchange
or conversion during the Lock-Up Period, unless otherwise permitted pursuant to the terms of this lock-up agreement. In addition,
no provision herein shall be deemed to restrict or prohibit the entry into or modification of a so-called “10b5-1”
plan at any time (other than the entry into or modification of such a plan in such a manner as to cause the sale of any Lock-Up
Securities within the Lock-Up Period).

 

The undersigned understands
that the Company and the Representative are relying upon this lock-up agreement in proceeding toward consummation of the Public
Offering. The undersigned further understands that this lock-up agreement is irrevocable and shall be binding upon the undersigned’s
heirs, legal representatives, successors and assigns.

 

The undersigned understands
that this lock-up agreement shall terminate and be void and of no further force or effect upon the earlier to occur, if any, of
(i) the Company notifying the Representative or the Representative notifying the Company in writing that it does not intend to
proceed with the Public Offering, (ii) the Company withdrawing the registration statement registering the Shares or deregisters
all the Shares covered by the registration statement, (iii) the Underwriting Agreement not being executed by February 14, 2014
(provided that the Company may by written notice to the undersigned prior to February 14, 2014, extend such date for a period of
up to an additional three months), or (iv) the Underwriting Agreement (other than the provisions thereof which survive termination)
terminating prior to payment for and delivery of the Shares to be sold thereunder.

 

    	- 2 -

    	 

    

 

Whether or not the
Public Offering actually occurs depends on a number of factors, including market conditions. Any Public Offering will only be made
pursuant to an Underwriting Agreement, the terms of which are subject to negotiation between the Company and the Representative.

 

	 	Very truly yours,
	 	 
	 	 
	 	(Name - Please Print)
	 	 
	 	 
	 	(Signature)
	 	 
	 	 
	 	(Name of Signatory, in the case of entities - Please Print)
	 	 
	 	 
	 	(Title of Signatory, in the case of entities - Please Print)
	 	 	 
	 	Address:	 
	 	 	 
	 	 	 
	 	 	 
	 	 	 

 

    	- 3 -

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