Document:

EX-10.3

 Exhibit 10.3 

 

HARMONY BIOSCIENCES HOLDINGS, INC. 

2020 INCENTIVE AWARD PLAN 

STOCK OPTION GRANT NOTICE 

Harmony Biosciences Holdings, Inc., a Delaware corporation (the “Company”) has granted to the participant listed below
(“Participant”) the stock option (the “Option”) described in this Stock Option Grant Notice (the “Grant Notice”), subject to the terms and conditions of the Harmony Biosciences
Holdings, Inc. 2020 Incentive Award Plan (as amended from time to time, the “Plan”) and the Stock Option Agreement attached hereto as Exhibit A (the “Agreement”), both of which are incorporated
into this Grant Notice by reference. Capitalized terms not specifically defined in this Grant Notice or the Agreement have the meanings given to them in the Plan. 

 

			
		
	Participant:	  	
		
	Grant Date:	  	
		
	Exercise Price per Share:	  	[Can be no less than 100% of the FMV on the Grant Date]
		
	Shares Subject to the Option:	  	
		
	Final Expiration Date:	  	[Can be no later than 10th anniversary of Grant Date]
		
	Vesting Commencement Date:	  	
		
	Vesting Schedule:	  	[To be specified]
		
	Type of Option	  	[Incentive Stock Option]/[Non-Qualified Stock Option]

 By accepting (whether in writing, electronically or otherwise) the Option, Participant agrees to be
bound by the terms of this Grant Notice, the Plan and the Agreement. Participant has reviewed the Plan, this Grant Notice and the Agreement in their entirety, has had an opportunity to obtain the advice of counsel prior to executing this Grant
Notice and fully understands all provisions of the Plan, this Grant Notice and the Agreement. Participant hereby agrees to accept as binding, conclusive and final all decisions or interpretations of the Administrator upon any questions arising under
the Plan, this Grant Notice or the Agreement. 
  

							
	HARMONY BIOSCIENCES HOLDINGS, INC.	 		  	PARTICIPANT
				
	By:	 	
                     
    
	 		  	  

	Name:	 	  
	 		  	[Participant Name]
	Title:	 	  
	 		  	

 Exhibit A 

STOCK OPTION AGREEMENT 

Capitalized terms not specifically defined in this Agreement have the meanings specified in the Grant Notice or, if not defined in the Grant
Notice, in the Plan. 
 ARTICLE I. 

GENERAL 
 1.1 Grant of
Option. The Company has granted to Participant the Option effective as of the grant date set forth in the Grant Notice (the “Grant Date”). 

1.2 Incorporation of Terms of Plan. The Option is subject to the terms and conditions set forth in this Agreement and the Plan, which is
incorporated herein by reference. In the event of any inconsistency between the Plan and this Agreement, the terms of the Plan will control. 

ARTICLE II. 
 PERIOD OF
EXERCISABILITY 
 2.1 Commencement of Exercisability. The Option will vest and become exercisable according to the vesting
schedule in the Grant Notice (the “Vesting Schedule”) except that any fraction of a Share as to which the Option would be vested or exercisable will be accumulated and will vest and become exercisable only when a whole Share
has accumulated. Notwithstanding anything in the Grant Notice, the Plan or this Agreement to the contrary, unless the Administrator otherwise determines, the Option will immediately expire and be forfeited as to any portion that is not vested and
exercisable as of Participant’s Termination of Service for any reason (after taking into consideration any accelerated vesting and exercisability which may occur in connection with such Termination of Service). 

2.2 Duration of Exercisability. The Vesting Schedule is cumulative. Any portion of the Option which vests and becomes exercisable will
remain vested and exercisable until the Option expires. The Option will be forfeited immediately upon its expiration. 
 2.3 Expiration of
Option. The Option may not be exercised to any extent by anyone after, and will expire on, the first of the following to occur: 
 (a)
The final expiration date in the Grant Notice; provided, however, such final expiration date may be extended pursuant to Section 5.3 of the Plan; 

(b) Except as the Administrator may otherwise approve, the expiration of three months from
the date of Participant’s Termination of Service, unless Participant’s Termination of Service is for Cause or by reason of Participant’s death or Disability; 

(c) Except as the Administrator may otherwise approve, the expiration of one year from the date of Participant’s Termination of Service by
reason of Participant’s death or Disability; and 
 (d) Except as the Administrator may otherwise approve, Participant’s
Termination of Service for Cause. 

  
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 ARTICLE III. 

EXERCISE OF OPTION 
 3.1
Person Eligible to Exercise. During Participant’s lifetime, only Participant may exercise the Option. After Participant’s death, any exercisable portion of the Option may, prior to the time the Option expires, be exercised by
Participant’s Designated Beneficiary as provided in the Plan. 
 3.2 Partial Exercise. Any exercisable portion of the Option or
the entire Option, if then wholly exercisable, may be exercised, in whole or in part, according to the procedures in the Plan at any time prior to the time the Option or portion thereof expires, except that the Option may only be exercised for whole
Shares. 
 3.3 Tax Withholding; Exercise Price. 

(a) Unless the Administrator otherwise determines, the Company shall withhold, or cause to be withheld, Shares otherwise vesting or issuable
under this Option in satisfaction of any exercise price and/or applicable withholding tax obligations. With respect to tax withholding obligations, the number of Shares which may be so withheld or surrendered shall be limited to the number of Shares
which have a fair market value on the date of withholding no greater than the aggregate amount of such liabilities based on the maximum individual statutory withholding rates in Participant’s applicable jurisdictions for federal, state, local
and foreign income tax and payroll tax purposes that are applicable to such taxable income. 
 (b) Participant acknowledges that Participant
is ultimately liable and responsible for all taxes owed in connection with the Option, regardless of any action the Company or any Subsidiary takes with respect to any tax withholding obligations that arise in connection with the Option. Neither the
Company nor any Subsidiary makes any representation or undertaking regarding the treatment of any tax withholding in connection with the awarding, vesting or exercise of the Option or the subsequent sale of Shares. The Company and the Subsidiaries
do not commit and are under no obligation to structure the Option to reduce or eliminate Participant’s tax liability. 
 ARTICLE IV.

 OTHER PROVISIONS 

4.1 Adjustments. Participant acknowledges that the Option is subject to adjustment, modification and termination in certain events as
provided in this Agreement and the Plan. 
 4.2 Notices. Any notice to be given under the terms of this Agreement to the Company must
be in writing and addressed to the Company in care of the Company’s Secretary at the Company’s principal office or the Secretary’s then-current email address or facsimile number. Any notice to be given under the terms of this
Agreement to Participant must be in writing and addressed to Participant (or, if Participant is then deceased, to the Designated Beneficiary) at Participant’s last known mailing address, email address or facsimile number in the Company’s
personnel files. By a notice given pursuant to this Section, either party may designate a different address for notices to be given to that party. Any notice will be deemed duly given when actually received, when sent by email, when sent by
certified mail (return receipt requested) and deposited with postage prepaid in a post office or branch post office regularly maintained by the United States Postal Service, when delivered by a nationally recognized express shipping company or upon
receipt of a facsimile transmission confirmation. 
 4.3 Titles. Titles are provided herein for convenience only and are not to serve
as a basis for interpretation or construction of this Agreement. 

  
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 4.4 Conformity to Securities Laws. Participant acknowledges that the Plan, the Grant
Notice and this Agreement are intended to conform to the extent necessary with all Applicable Laws and, to the extent Applicable Laws permit, will be deemed amended as necessary to conform to Applicable Laws. 

4.5 Successors and Assigns. The Company may assign any of its rights under this Agreement to single or multiple assignees, and this
Agreement will inure to the benefit of the successors and assigns of the Company. Subject to the restrictions on transfer set forth in this Agreement or the Plan, this Agreement will be binding upon and inure to the benefit of the heirs, legatees,
legal representatives, successors and assigns of the parties hereto. 
 4.6 Limitations Applicable to Section 16
Persons. Notwithstanding any other provision of the Plan or this Agreement, if Participant is subject to Section 16 of the Exchange Act, the Plan, the Grant Notice, this Agreement and the Option will be subject to any additional limitations
set forth in any applicable exemptive rule under Section 16 of the Exchange Act (including any amendment to Rule 16b-3) that are requirements for the application of such exemptive rule. To the extent
Applicable Laws permit, this Agreement will be deemed amended as necessary to conform to such applicable exemptive rule. 
 4.7 Entire
Agreement. The Plan, the Grant Notice and this Agreement (including any exhibit hereto) constitute the entire agreement of the parties and supersede in their entirety all prior undertakings and agreements of the Company and Participant with
respect to the subject matter hereof. 
 4.8 Agreement Severable. In the event that any provision of the Grant Notice or this
Agreement is held illegal or invalid, the provision will be severable from, and the illegality or invalidity of the provision will not be construed to have any effect on, the remaining provisions of the Grant Notice or this Agreement. 

4.9 Limitation on Participant’s Rights. Participation in the Plan confers no rights or interests other than as herein provided.
This Agreement creates only a contractual obligation on the part of the Company as to amounts payable and may not be construed as creating a trust. Neither the Plan nor any underlying program, in and of itself, has any assets. Participant will have
only the rights of a general unsecured creditor of the Company with respect to amounts credited and benefits payable, if any, with respect to the Option, and rights no greater than the right to receive the Shares as a general unsecured creditor with
respect to the Option, as and when exercised pursuant to the terms hereof. 
 4.10 Not a Contract of Employment. Nothing in the Plan,
the Grant Notice or this Agreement confers upon Participant any right to continue in the employ or service of the Company or any Subsidiary or interferes with or restricts in any way the rights of the Company and its Subsidiaries, which rights are
hereby expressly reserved, to discharge or terminate the services of Participant at any time for any reason whatsoever, with or without Cause, except to the extent expressly provided otherwise in a written agreement between the Company or a
Subsidiary and Participant. 
 4.11 Counterparts. The Grant Notice may be executed in one or more counterparts, including by way of
any electronic signature, subject to Applicable Law, each of which will be deemed an original and all of which together will constitute one instrument. 

4.12 Incentive Stock Options. If the Option is designated as an Incentive Stock Option: 

(a) Participant acknowledges that to the extent the aggregate fair market value of shares (determined as of the time the option with respect to
the shares is granted) with respect to which stock options intended to qualify as “incentive stock options” under Section 422 of the Code, including the Option, are exercisable for the first time by Participant during any calendar
year exceeds $100,000 or if for 

  
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any other reason such stock options do not qualify or cease to qualify for treatment as “incentive stock options” under Section 422 of the Code, such stock options (including the
Option) will be treated as non-qualified stock options. Participant further acknowledges that the rule set forth in the preceding sentence will be applied by taking the Option and other stock options into
account in the order in which they were granted, as determined under Section 422(d) of the Code. Participant also acknowledges that if the Option is exercised more than three months after Participant’s Termination of Service, other than by
reason of death or disability, the Option will be taxed as a Non-Qualified Stock Option. 
 (b)
Participant will give prompt written notice to the Company of any disposition or other transfer of any Shares acquired under this Agreement if such disposition or other transfer is made (a) within two years from the Grant Date or
(b) within one year after the transfer of such Shares to Participant. Such notice will specify the date of such disposition or other transfer and the amount realized, in cash, other property, assumption of indebtedness or other consideration,
by Participant in such disposition or other transfer. 
 * * * * * 

  
 4EX-4.4

 Exhibit 4.4 

ELI LILLY AND COMPANY 

Officers’ Certificate Pursuant to 

Section 3.01 of the Indenture 

                    , 2020 

 
  

The undersigned, Philip L. Johnson, Senior Vice President, Finance, and Treasurer of Eli Lilly and Company, an Indiana corporation (the
“Company”), and Crystal T. Williams, Assistant General Counsel and Assistant Corporate Secretary of the Company, pursuant to Section 3.01 of the Indenture, dated as of February 1, 1991 (the “Indenture”),
between the Company and Deutsche Bank Trust Company Americas (as successor to Citibank, N.A.), as trustee (the “Trustee”), as authorized by resolutions of the Board of Directors of the Company, dated February 7, 2019, and
minutes of the Risk Management Committee of the Company at its meetings on April 16, 2020 and August 17, 2020 (collectively, the “Board Resolutions”), do hereby certify as follows: 

(i) There is hereby established one series of debt securities to be issued under the Indenture. The title of such series of the debt
securities shall be the “2.500% Notes due 2060” (the “2.500% Notes”). In addition, there is hereby authorized an issuance of additional Securities under the Company’s existing series of debt securities titled the
“2.250% Notes due 2050” (the “Additional 2.250% Notes” and, together with the 2.500% Notes, the “Notes”), which were initially established pursuant to an Officers’ Certificate, dated May 5, 2020,
resolutions of the Board of Directors of the Company, dated February 7, 2019, and a meeting of the Risk Management Committee of the Company on April 16, 2020. The Additional 2.250% Notes shall have the same terms as, and shall constitute a
single series of Securities with, the existing 2.250% Notes due 2050 under the Indenture. 
 (ii) The 2.500% Notes shall be in the form, and
shall have the terms, set forth as Annex A. The Notes shall be issued in the form of Registered Securities and shall not be issued in the form of Bearer Securities. 

(iii) The initial limit upon the aggregate principal amount of the 2.500% Notes that may be authenticated and delivered under the Indenture
(except for Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, other Notes pursuant to Sections 3.04, 3.05, 3.06, 4.03 or 10.04 of the Indenture) is eight hundred and fifty million Dollars
($850,000,000), and the limit upon the aggregate principal amount of the 2.250% Notes due 2050 established in connection with the initial issuance of such 2.250% Notes due 2050 is hereby increased from one billion Dollars ($1,000,000,000) to one
billion two hundred and fifty million Dollars ($1,250,000,000); provided, however, that, without the consent of the Holders of any Securities, the Company may issue additional Securities having the same terms as the Notes of a
particular series other than the date of original issuance and the first Interest Payment Date applicable to such additional Securities. Any such additional Securities shall constitute a single series of Securities with the applicable Notes
under the Indenture. 
 (iv) The principal amount of the 2.500% Notes shall be payable on September 15, 2060, unless redeemed prior to
such time in accordance with clause (xi) below. 

 (v) The 2.500% Notes shall bear interest at the rate of 2.500% per annum from
August 25, 2020. The Interest Payment Dates for the 2.500% Notes shall be March 15 and September 15 of each year, commencing on March 15, 2021. 

(vi) Interest shall be payable to the person in whose name a 2.500% Note (or any Predecessor Security) is registered at the close of business
on the Regular Record Date immediately preceding the applicable Interest Payment Date (or, in the case of Defaulted Interest, in the manner provided in Section 3.07 in the Indenture). The “Regular Record Date” for the 2.500% Notes
shall be March 1 and September 1 (whether or not a Business Day (as defined in the 2.500% Notes)). 
 (vii) The 2.500% Notes shall
be denominated, and amounts due thereon shall be payable, solely in Dollars. 
 (viii) The Company shall at all times maintain a Place of
Payment for the 2.500% Notes in the Borough of Manhattan, The City of New York. The Company initially appoints Deutsche Bank Trust Company Americas, with a corporate trust office at 60 Wall Street, 24th Floor, Mail Stop: NYC60-2407, New York, New
York 10005, for such purpose. 
 (ix) The Trustee is hereby appointed as the initial Paying Agent and the initial Security Registrar with
respect to the 2.500% Notes. 
 (x) The 2.500% Notes shall not be subject to any sinking fund or analogous provisions, and no Holder of the
2.500% Notes shall have any right to cause the Company to redeem any 2.500% Notes at the option of the Holder. 
 (xi) The 2.500% Notes
shall be redeemable, in whole or in part, at the option of the Company at any time at the redemption prices determined in accordance with, and upon the terms and the conditions set forth in, the 2.500% Notes and the Indenture. 

(xii) The 2.500% Notes shall be issuable in the form of Global Securities registered in the name of The Depository Trust Company, as
Depositary, or its nominee. The Global Securities representing the 2.500% Notes may be exchanged for definitive 2.500% Notes only in the circumstances set forth in the seventh and eighth paragraphs of Section 3.05 of the Indenture and in
accordance with Section 3.05 of the Indenture. 
 (xiii) The 2.500% Notes shall be issued in minimum denominations of two thousand
Dollars ($2,000.00) and any integral multiples of one thousand Dollars ($1,000.00) in excess thereof. 
 (xiv) Section 12.02 of the
Indenture shall be applicable to the 2.500% Notes. 
 (xv) The 2.500% Notes shall rank equally and pari passu with all other
unsecured and unsubordinated indebtedness of the Company. 
 (xvi) The Company shall not pay any additional amounts on any of the 2.500%
Notes to any Person, including any Holder who is not a United States Person, in respect of any tax, assessment or governmental charge withheld or deducted. 

  
 2 

 (xvii) For purposes of the 2.500% Notes, the following terms shall have the meanings set
forth below: (1) “Discharged” means that the Company will be deemed to have paid and discharged the entire indebtedness represented by, and obligations under, the Securities of the series as to which Section 12.02 of the Indenture is
specified as applicable and to have satisfied all the obligations under the Indenture relating to the Securities of such series (and the Trustee, at the expense of the Company, will execute proper instruments acknowledging the same), except
(A) the rights of Holders thereof to receive, from the trust fund described in Section 12.02(q)(1) of the Indenture, payment of the principal of and the interest, if any, on such Securities when such payments are due, (B) the
Company’s obligations with respect to such Securities under Sections 3.05 and 3.06 (insofar as applicable to Securities of such series), 12.02 and 5.02 of the Indenture and the Company’s obligations to the Trustee under Section 7.05
of the Indenture, (C) the rights of Holders of Securities of any series with respect to the currency or currency units in which they are to receive payments of principal, premium, if any, and, interest and (D) the rights, powers, trusts,
duties and immunities of the Trustee hereunder, will survive such discharge. The Company will reimburse the trust fund for any loss suffered by it as a result of any tax, fee or other charge imposed on or assessed against deposited U.S. Government
Obligations or Foreign Government Securities, as the case may be, or any principal or interest paid on such obligations, and, subject to the provisions of Section 7.05 of the Indenture, will indemnify the Trustee against any claims made against
the Trustee in connection with any such loss. 
 (2) “Interest Payment Date,” when used with respect to any Security, means the
Stated Maturity of an installment of interest on such Security. 
 (3) “Special Record Date” for the payment of any Defaulted
Interest on the Registered Security of any series means a date fixed by the Trustee pursuant to Section 3.07 of the Indenture. 
 (4)
“Valuation Date” has the meaning specified in Section 3.11(e) of the Indenture.  
 (xviii) Each of the undersigned
has read and understands the provisions of the Indenture setting forth the covenants and conditions relating to the authentication and delivery by the Trustee of the Notes, and in respect of compliance with which this certificate is being delivered,
and all definitions in the Indenture relating thereto. 
 (xix) Each of the undersigned has examined the Board Resolutions adopted as of or
prior to the date hereof relating to the issuance, execution, authentication, delivery and dating of the Notes, and such agreements, certificates of public officials, certificates of officers or other representatives of the Company and such other
documents, certificates and corporate or other records as he or she has deemed necessary or appropriate as a basis for the opinion hereinafter expressed. 

(xx) The examinations or investigations described in paragraphs (xviii) and (xix) are sufficient to enable each of the undersigned to
express an informed opinion as to whether or not the covenants and conditions precedent referred to above have been complied with in accordance with the terms of the Indenture. 

  
 3 

 (xxi) In the opinion of each of the undersigned, all covenants and conditions precedent to
the issuance by the Company and the authentication and delivery by the Trustee of the Notes, as requested in the order, dated as of the date hereof, pursuant to which the Company has requested that the Trustee authenticate and deliver the Notes,
have been complied with in accordance with the terms of the Indenture. 
 Capitalized terms used herein without definition shall have the
respective meanings ascribed to such terms in the Indenture. 
 [The Remainder of this Page Intentionally Left Blank; Signature Page
Follows] 

  
 4 

 IN WITNESS WHEREOF, the undersigned have
hereunto set their hands on the date first set forth above. 
  

					
	 ELI LILLY AND
COMPANY

		
	By	 	  

		 	Name:	 	Philip L. Johnson
		 	Title:	 	Senior Vice President, Finance, and
		 		 	Treasurer
		
	By	 	  

		 	Name:	 	Crystal T. Williams
		 	Title:	 	Assistant General Counsel and
		 		 	Assistant Corporate Secretary

 [Signature Page to Officers’ Certificate Pursuant to the Indenture] 

 Annex A 

FORM OF 2.500% NOTE 

 ELI LILLY AND COMPANY 

Form of 2.500% Note due 2060 
  

			
	 Certificate No. [*]
	  	CUSIP No. 532457 BZ0
	 Registered Global Security
	  	ISIN No. US532457BZ08

 UNLESS THIS GLOBAL NOTE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW
YORK CORPORATION (“DTC”), TO THE COMPANY OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY NOTE ISSUED IS REGISTERED IN THE NAME OF [*] OR IN SUCH OTHER NAME AS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC AND ANY
PAYMENT IS MADE TO [*], ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL SINCE THE REGISTERED OWNER HEREOF, [*], HAS AN INTEREST HEREIN. 

UNLESS AND UNTIL IT IS EXCHANGED IN WHOLE OR IN PART FOR NOTES IN DEFINITIVE REGISTERED FORM, THIS GLOBAL NOTE MAY NOT BE TRANSFERRED EXCEPT AS
A WHOLE BY DTC TO A NOMINEE OF DTC, OR BY A NOMINEE OF DTC TO DTC OR ANOTHER NOMINEE OF DTC, OR BY DTC OR ANY SUCH NOMINEE TO A SUCCESSOR DEPOSITARY OR TO A NOMINEE OF SUCH SUCCESSOR DEPOSITARY. 

ELI LILLY AND COMPANY, an Indiana corporation (the
“Company,” which term includes any successor corporation under the Indenture referred to herein), for value received, hereby promises to pay to [*], or its registered assigns, the principal amount of [*] Dollars ($[*]) on
September 15, 2060 (the “Stated Maturity Date”), unless redeemed on any Redemption Date (as defined on the reverse hereof) (the Stated Maturity Date or any Redemption Date is referred to herein as the
“Maturity Date” with respect to the principal amount repayable on such date), upon surrender of this Note at the office or agency of the Company for such payment in The City of New York, in such coin or currency of the United
States of America as at the time of payment shall be legal tender for the payment of public and private debts, and to pay interest on the outstanding principal amount until the Maturity Date at the rate of 2.500% per annum, in like coin or currency,
semi-annually on March 15 and September 15 of each year, commencing on March 15, 2021, until the date on which payment of said principal amount has been made or duly provided for; provided, however, that if this Note is in the
form of a Global Security, then payments of principal of or premium, if any, or interest on this Note may be made at the Company’s option by wire transfer of immediately available funds to the account specified by the Depositary for this Note;
provided further, that if this Note is not in the form of a Global Security, then payments of principal of and premium, if any, and interest on this Note may be made at the Company’s option by check mailed to the address of the person
entitled thereto as 

 
such address shall appear in the records of the Security Registrar. Interest on this Note shall accrue on the outstanding principal amount thereof from, and including, the most recent Interest
Payment Date to which interest has been paid or provided for or, if no interest has been paid or duly provided for, from, and including, August 25, 2020, in each case to, but excluding, the applicable Interest Payment Date or the Maturity Date,
as the case may be. Interest shall be computed on the basis of a 360-day year of twelve 30-day months. The interest payable on any Interest Payment Date shall be payable
to the person in whose name this Note is registered at the close of business on the March 1 and September 1 (whether or not a Business Day) immediately preceding such Interest Payment Date, except as otherwise provided in the Indenture.

 If the Maturity Date or any Interest Payment Date falls on a day that is not a Business Day, principal, premium, if any, and interest, if
any, payable with respect to the Maturity Date or such Interest Payment Date, as the case may be, shall be paid on the next succeeding Business Day with the same force and effect as if made on the Maturity Date or such Interest Payment Date, as the
case may be, and no additional interest shall accrue on the amount so payable for the period from and after the Maturity Date or such Interest Payment Date, as the case may be, to the next succeeding Business Day. As used herein,
“Business Day” shall mean any day, other than a Saturday or Sunday, that is neither a legal holiday nor a day on which banking institutions are authorized or required by law or regulation to close in The City of New York.

 This Note is issued pursuant to, and shall be governed by, that certain Indenture (the “Indenture”), dated as of
February 1, 1991, between the Company and Deutsche Bank Trust Company Americas (as successor to Citibank, N.A.), as trustee (the “Trustee”). Capitalized terms used in this Note without definition shall have the
respective meanings ascribed to them in the Indenture. 
 The provisions of this Note are continued on the reverse hereof, and such
continued provisions shall for all purposes have the same effect as though fully set forth at this place. 
 Unless the certificate of
authentication hereon has been executed by the Trustee by the manual signature of one of its authorized officers, this Note shall not be entitled to the benefit under the Indenture or be valid or obligatory for any purpose. 

[This Space Intentionally Left Blank] 

 IN WITNESS WHEREOF, Eli Lilly and Company has
caused this instrument to be duly signed. 
  

			
	 ELI LILLY AND
COMPANY

		
	By:	 	  

		 	Name:
		 	Title:
		
		 	  

		 	Name:
		 	Title:

 [SEAL] 

 This is one of the Securities of the series designated therein issued under the
within-mentioned Indenture. 
  

			
	Dated:	 	  

  

			
	 DEUTSCHE BANK TRUST COMPANY
AMERICAS,
 as Trustee

		
	By:	 	 
		 	Authorized Officer

 [REVERSE OF NOTE] 

This Note is one of a duly authorized issue of a series of debt securities (the “Securities”) of the Company,
designated as its 2.500% Notes due 2060 (the “Notes”). The Securities, including the Notes, are all issued or to be issued under and pursuant to the Indenture, to which Indenture, and all Board Resolutions and Officers’
Certificates as provided therein, reference is hereby made for a description of the rights, limitation of rights, obligations, duties and immunities thereunder of the Company, the Trustee and the Holders of the Notes, and the terms upon which the
Notes are, and are to be, authenticated and delivered. The Notes are initially limited to eight hundred and fifty million Dollars ($850,000,000) in aggregate principal amount; provided, however, that the Company may at any time issue
additional Securities under the Indenture in unlimited amounts having the same terms as the Notes other than the date of original issuance and the first Interest Payment Date applicable thereto, and such Securities shall be treated as a single
series with the Notes for all purposes under the Indenture. 
 This Note shall constitute part of the Company’s unsecured and
unsubordinated obligations and shall rank equally in right of payment with all of the Company’s other existing and future unsecured and unsubordinated indebtedness. This Note shall be issuable in fully registered form only, in minimum
denominations of two thousand Dollars ($2,000) and any integral multiples of one thousand Dollars ($1,000) in excess of that amount. 
 In
case an Event of Default shall have occurred and be continuing with respect to this Note, the principal hereof may be declared due and payable, and upon such declaration shall become due and payable, in the manner, with the effect, and subject to
the conditions provided in the Indenture. The Indenture permits the Holders of at least a majority in aggregate principal amount of the Notes at the time outstanding to, on behalf of the Holders of all of the Notes and in the manner and subject to
the provisions of the Indenture, waive certain past defaults and rescind and annul such past declarations and their consequences under the Indenture. 

The Indenture contains provisions permitting the Company and the Trustee, with consent of the Holders of not less than a majority of the
aggregate principal amount of the Notes at the time outstanding, evidenced as provided in the Indenture, to execute supplemental indentures for the purpose of adding any provisions to or changing in any manner or eliminating any of the provisions of
the Indenture or of any supplemental indenture with respect to the Notes or of modifying in any manner the rights of the Holders of the Notes; provided, however, that no such supplemental indenture shall (i) extend the fixed
maturity, or the earlier optional date of maturity, if any, of any Note, or reduce the principal amount thereof or the premium thereon, if any, or reduce the rate or extend the time of payment of interest, if any, thereon or make the principal
thereof or premium, if any, or interest, if any, thereon payable in any currency other than as provided pursuant to the Indenture or this Note, without the consent of the Holders of each Note so affected; or (ii) reduce the aforesaid percentage
of the Notes, the Holders of which are required to consent to any such supplemental indenture, without the consent of the Holders of all Notes then outstanding. 

The Notes shall not be entitled to the benefit of any mandatory redemption, sinking fund or analogous provisions. 

 Upon such notice as specified below and in accordance with the Indenture and the terms of
this Note, the Notes are subject to redemption, in whole or in part, at the election of the Company at any time or from time to time, on a date fixed for redemption (a “Redemption Date”) prior to the Par Call Date and at a
“redemption price” equal to the greater of the following amounts: 
  

	 	(i)	 100% of the principal amount of the Notes being redeemed on such Redemption Date; and 

 

	 	(ii)	 the sum of the present values of the remaining scheduled payments of principal and interest on the Notes being
redeemed that would be due if such Notes matured on the Par Call Date (not including the amount, if any, of unpaid interest accrued to, but excluding, such Redemption Date), discounted to such Redemption Date on a semi-annual basis (assuming a 360-day year consisting of twelve 30-day months) at the Treasury Rate (as defined below), plus 0.200% (or 20 basis points); 

plus, in each case, unpaid interest accrued on such Notes to, but excluding, such Redemption Date. If the Company redeems all or any part of the Notes
on or after the Par Call Date, it shall pay a redemption price equal to 100% of the principal amount of the Notes being redeemed plus accrued and unpaid interest hereon. 

Notwithstanding the foregoing, installments of interest on the Notes that are due and payable on each Interest Payment Date falling on or
prior to a Redemption Date shall be payable on such Interest Payment Date to the Holder(s) as of the close of business on the Regular Record Date immediately preceding such Interest Payment Date. 

The Company shall mail notice of each redemption at least 10 days but not more than 60 days before the Redemption Date to each Holder of Notes
to be redeemed. Each notice of redemption shall (i) specify the Redemption Date and the redemption price at which the Notes are to be redeemed, (ii) state the applicable conditions precedent to such redemption, if any, as described below,
and (iii) state that payment of the redemption price of the Notes to be redeemed, together with interest accrued thereon to the Redemption Date (except that if such Redemption Date is an Interest Payment Date, such interest due on such date
shall be payable to the Holder on the Regular Record Date for such Interest Payment Date), will be made at the office or agency to be maintained by the Company in accordance with Section 5.02 of the Indenture (or, if desired by the Company, at
the principal office of the Trustee) upon presentation and surrender of such Notes and that from and after said date any interest thereon will cease to accrue. 

Any notice of redemption may, at the Company’s discretion, be subject to one or more conditions precedent, including completion of a
corporate transaction. In such event, the related notice of redemption shall describe each such condition and, if applicable, shall state that, at the Company’s discretion, the Redemption Date may be delayed until such time (including more than
60 days after the notice of redemption was given) as any or all such conditions shall be satisfied (or waived by the Company in its sole discretion), or such redemption may not occur and such notice may be rescinded in the event that any or all such
conditions shall not have been 

 
satisfied or waived by the Redemption Date, or by the Redemption Date so delayed. If any such redemption has been rescinded or delayed, the Company shall provide written notice to the Trustee
prior to the close of business two Business Days prior to the Redemption Date and shall deliver a written request to the Trustee to promptly provide such notice to each Holder, and upon receipt the Trustee shall provide such notice to each Holder.
Subject to any delay in the Redemption Date or rescission of the notice of redemption as described above, once notice of redemption is mailed, the Notes called for redemption shall become due and payable on the applicable Redemption Date at the
applicable redemption price. 
 “Comparable Treasury Issue” means, for the Notes, the United States Treasury
security selected by the Reference Treasury Dealer as having a maturity comparable to the remaining term of such Notes to be redeemed (assuming for this purpose that the Notes matured on the Par Call Date) that would be utilized, at the time of
selection and in accordance with customary financial practice, in pricing new issues of corporate debt securities of comparable maturity to the remaining term of such Notes. 

“Comparable Treasury Price” means, with respect to any Redemption Date prior to the Par Call Date, (A) if the
Company obtains five or more Reference Treasury Dealer Quotations for such Redemption Date, the average of such Reference Treasury Dealer Quotations after excluding the highest and lowest of such Reference Treasury Dealer Quotations, (B) if the
Company obtains fewer than five but more than one Reference Treasury Dealer Quotations, the average of such Reference Treasury Dealer Quotations, or (C) if the Company obtains only one Reference Treasury Dealer Quotation, such Reference
Treasury Dealer Quotation. 
 “Par Call Date” means March 15, 2060. 

“Reference Treasury Dealer” means (A) each of BNP Paribas Securities Corp., Citigroup Global Markets Inc., J.P.
Morgan Securities LLC and Morgan Stanley & Co. LLC (or their respective affiliates that are Primary Treasury Dealers), and their respective successors; provided, however, that if any of the foregoing shall cease to be a
primary U.S. Government securities dealer in the United States (a “Primary Treasury Dealer”), the Company shall substitute therefor another Primary Treasury Dealer, and (B) any other Primary Treasury Dealer(s) selected
by the Company. 
 “Reference Treasury Dealer Quotation” means, with respect to each Reference Treasury Dealer and
any Redemption Date prior to the Par Call Date, the average, as determined by the Company, of the bid and ask prices for the Comparable Treasury Issue for such Notes (expressed in each case as a percentage of the principal amount of the Notes)
quoted in writing to the Company by such Reference Treasury Dealer at 5:00 p.m. (New York City time) on the third Business Day preceding such Redemption Date. 

“Treasury Rate” means, with respect to any Redemption Date prior to the Par Call Date, the rate per annum equal to the
semi-annual equivalent yield to maturity of the Comparable Treasury Issue, assuming a price for the Comparable Treasury Issue (expressed as a percentage of the principal amount of the Notes to be redeemed) equal to the Comparable Treasury Price for
such Redemption Date. 

 On and after any Redemption Date, interest shall cease to accrue on the Notes or any portion
of the Notes called for redemption (unless the Company defaults in the payment of the redemption price therefor). Before any Redemption Date, the Company shall deposit with a Paying Agent (or the Trustee) money sufficient to pay the redemption price
of the Notes to be redeemed on such date. If fewer than all of the Notes are to be redeemed, then the Notes to be redeemed shall be selected by lot by the Depositary, in the case of Notes represented by a Global Security, or by the Trustee by a
method the Trustee deems to be fair and appropriate, in the case of Notes that are not represented by a Global Security. The Notes are subject to the defeasance provisions set forth in Section 12.02 of the Indenture. 

The Company shall not pay any additional amounts on any of the Notes to any person, including any Holder who is not a United States person in
respect of any tax, assessment or governmental charge withheld or deducted. 
 No reference herein to the Indenture and no provision of this
Note or of the Indenture or of any Board Resolution shall alter or impair the obligation of the Company, which is absolute and unconditional, to pay the principal of and premium, if any, and interest on this Note at the times and places and at the
rate and in the coin and currency herein prescribed. 
 This Note is transferable by the Holder hereof in person or by his or her attorney
duly authorized in writing on the books of the Company at the office or agency to be maintained by the Company for that purpose in The City of New York, but only in the manner, subject to the limitations and upon payment of any tax or governmental
charge for which the Company may require reimbursement as provided in the Indenture, and upon surrender and cancellation of this Note. Upon any registration of transfer, a new registered Note or Notes, of authorized denomination or authorized
denominations and like tenor and terms, and in the same aggregate principal amount, shall be issued to the transferee in exchange therefor. 

The Company, the Trustee, any Paying Agent and any Security Registrar may deem and treat the Holder hereof as the absolute owner of this Note
(whether or not this Note shall be overdue and notwithstanding any notations of ownership or other writing hereon made by anyone other than the Security Registrar) for the purpose of receiving payment of or on account of the principal hereof and
premium, if any, and interest due hereon as herein provided and for all other purposes, and none of the Company, the Trustee, any Paying Agent or any Security Registrar shall be affected by any notice to the contrary. 

No recourse shall be had for the payment of the principal of or premium, if any, or interest on this Note, or for any claim based hereon, or
otherwise in respect hereof, or based on or in respect of the Indenture or any supplemental indenture thereto or any Board Resolution, against any Person other than the Company or against any incorporator, stockholder, officer or director, past,
present or future, as such, of the Company or any other Person, whether by virtue of any constitution, statute or rule of law, or by the enforcement of any assessment or penalty or otherwise, all such liability being, by the acceptance hereof and as
part of the consideration for the issuance of this Note, expressly waived and released. 
 This Note shall be governed by and construed in
accordance with the laws of the State of New York.

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