Document:

Exhibit 10.34

 

 

 

 

 

 

Municipal Construction Wastes Disposal and Renewable
Use Treatment Special

Management Agreement

 

 

 

 

 

 

Party A:         Pingdingshan
Municipal Bureau of Housing and Urban-Rural Development

 

Party B:          Pingdingshan Xulong Renewable Resource
Co., Ltd.

 

    	 

    	 

    

 

Table of Contents

 

	Chapter 1 General Provisions	3
	Chapter 2 Terms and Definitions 	4
	Chapter 3 Awarding and Supervision of Concession	5
	Chapter 4 Party B’s Rights and Obligations	6
	Chapter 5 Service Standards	7
	Chapter 6 Determination Method and Standard and Adjustment Procedure of Charges	9
	Chapter 7 Performance Bond	10
	Chapter 8 Project Operation	11
	Chapter 9 Termination and Cancellation of Concession	11
	Chapter 10 Breach Liability	12
	Chapter 11 Dispute Settlement 	14
	Chapter 12 Confidentiality	14
	Chapter 13 Notice 	15
	Chapter 14 Others	15

 

    	

    	 

    

 

Municipal Construction Wastes Disposal and
Renewable Use Treatment Special Management Agreement

 

Chapter 1 General Provisions

 

1.1 Party A: Pingdingshan Municipal Bureau
of Housing and Urban/Rural Construction (hereinafter referred to as Party A)

 

Address:

 

	Legal representative: [hw:] Fan Hai	Title: [hw:] Director

 

Party B: Pingdingshan Xulong Renewable Resources
Co., Ltd. (hereinafter referred to as Party B)

 

	Address:	[hw:] East of Xihuan Road, Xinhua 

District, Pingdingshan (inside the yard

 of Pingdingshan City Hengji Concrete Co., Ltd.)	 	Registration No.:	 [hw:] 410400000026538 (1-1)
	 	 	 	 	 
	Legal representative: [hw:] You Yongjun	 	Title: [hw:] Manager

 

1.2 Purposes and criteria of the concession 

 

In
order to beautify urban environment, save social investment costs, avoid the environment pollution arising from cleaning and transportation
with general-purpose vehicles, simple landfilling, stacking and simple handling of urban construction wastes as well as realize
the standard and collective disposal of and recycle urban construction wastes, Party B has participated in and won the tender
for concessionary disposal of urban construction wastes of Pingdingshan pursuant to the Contract Law of the People’s Republic
of China, Measures of Administration of Concessionary Operators of Public Utilities (Ministry of Construction Ordinance
No. 126), Notice on Levying Urban Living Waste Disposal Fees (Ping Jia Fei (2005) No. 145) and relevant other laws and
regulations. As such, it has become the concessionary operator of urban construction wastes of Pingdingshan. After negotiations,
both parties have signed this special management agreement for the purpose mentioned above.

 

1.3 Principles of concession 

 

Both parties shall
observe the principles of fairness, equality, openness and priority of public interests.

 

1.4 Application of this Agreement

 

1.4.1 This Agreement shall be one of the criteria
by which Party B cleans, transports and recycles the urban construction wastes within the prescribed region during the concession
period and also one of the criteria by which Party A supervises Party B’s operations during the concession period.

 

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1.4.2 This Agreement shall
not constitute a partnership or joint venture contract between both parties.

 

1.4.3 This Agreement shall not restrict or
otherwise affect Party A’s rights to supervise, check and charge relevant work according to laws in the process of city administration.

 

Chapter 2 Terms and Definitions

 

2. The following terms
and definitions shall be applicable in this Agreement: 

 

2.1 Law: applicable laws,
regulations, bylaws, jurisdictional interpretation and other normative documents with legal effects.

 

2.2 Construction waste:
the waste soils, materials, sludge and other wastes generated by project owners, contractors and residents during new construction,
reconstruction, expansion, dismantling, decoration and renovation of various types of buildings, constructions, pipelines, botanical
and greening works and roads.

 

2.3 Concession: the rule
by which the government chooses the investor or operator of a public utilities project through market competition and authorize
it to operate a certain public utilities product or provide certain services within a certain scope and period.

 

2.4 Validity date: the validity
date of the Agreement as specified herein.

 

2.5 Approval: the license,
permit, approval, confirmation and registration that Party B needs to acquire from relevant governmental authority for the performance
of this Agreement.

 

2.6 Performance bond: the
performance guarantee document that is issued by a financial institution acceptable to Party A and provided by Party B to Party
A, including security, letter of guarantee, etc.

 

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2.7 Breach of contract:
either party’s failure to perform or fully perform obligations of this Agreement provided that such failure is not caused
by force majeure.

 

2.8 Day, month, quarter
and year: calendar day, month, quarter and year.

 

2.9 Environmental pollution:
phenomenon when the cleaning, transport and disposal of construction wastes cause the content or concentration of a particular
substance to reach a harmful level on the earth surface, on the ground, underground, in the air and in any water body so that personal
health or the ecology and environment is undermined.

 

2.10 Force majeure: the
event or situation that cannot be reasonably foreseen, overcome or avoided upon signing of this Agreement, including but not
limited to:

 

(1) Lightning, earthquake,
volcanic eruption, landslide, flood, rainstorm, tsunami, typhoon, hurricane or drought;

 

(2) Epidemic and famine;

 

(3) War, invasion, armed
conflict, hostile foreign conducts, embargo, use of military force, riot or terrorist attack;

 

(4) National, regional,
municipal or industrial strike;

 

(5) Change of national policy,
e.g. nationalization of construction waste disposal facility, etc;

 

(6) Any import limit or
quota limit implemented by relevant national governmental authority;

 

Chapter 3 Awarding and Supervision of Concession

 

3.1 Awarding of concession

 

3.1.1 Party A authorizes
Party B to clean, transport and recycle construction wastes within the specified scope and period.

 

3.1.2 Party B’s concession
shall remain valid for 20 years, effective from the effectiveness date of this Agreement until 20 years later.

 

3.1.3 Concessionary area:
urban area of Pingdingshan City unless otherwise specified.

 

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3.1.4 Party B shall obtain
the qualifications for cleaning, transport and recycling of construction wastes according to relevant state laws. Before such qualifications
are obtained, Party B shall not engage in any activity relating to cleaning, transport and recycling of construction wastes.

 

3.1.5 Party B shall register
its qualifications with Party A.

 

3.1.6 Party A shall not
authorize another enterprise, organization and individual to invest, construct and operate the same project during the concession
period unless otherwise permitted herein.

 

3.1.7 Party A shall assist
Party B to enjoy the corresponding preferential policies according to relevant regulations.

 

3.1.8 Where Party A is renamed,
merged, split or canceled or its function and authority is amended or its jurisdiction adjusted, the corresponding organ shall
succeed to all rights and obligations of Party A specified herein.

 

3.1.9 Without Party A’s
written approval, Party B shall not mortgage, transfer, lease and divide the concession.

 

3.1.10 Party A may invite
Party B to attend the government’s formulation of near and long-term comprehensive utilization plan of construction wastes.

 

3.1.11 Party B’s concession
activity shall not violate the law and Party B shall not conduct concession activities through illegal means or guarantee measures.

 

3.2 Supervision of concession
rights

 

3.2.1 Party A has the right
to supervise the total process of Party B’s concession activities (including but not limited to conformity of the total process
of cleaning, transport and recycling of construction wastes and the disposal of products to relevant standards and regulations).

 

3.2.2 Party A shall not
interfere with Party B’s normal production and operation work when it conducts supervising activities according to laws and
this Agreement.

 

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Chapter 4 Party B’s Rights and Obligations

 

4.1 Party B’s rights

 

4.1.1 Enjoy the special
right to clean, transport and recycle construction wastes according to this Agreement

 

4.1.2 Enjoy the right to
invest, construct and develop the devices for cleaning, transport and recycling of construction wastes within the scope of concession.

 

4.1.3 Other rights specified
in law and this Agreement

 

4.2 Party B’s obligations

 

4.2.1 Party B must observe
the legal supervision and management of Party A.

 

4.2.2 Where Party B changes
its name, address, legal representative, shareholding structure and other major conditions, it shall notify Party A in advance
and obtain Party A’s approval.

 

4.2.3 Party B shall ensure
soundness of facilities and equipment; guarantee the availability of capital investments in production facilities, equipment operation,
maintenance, refitting and renovation, etc.

 

4.2.4 Without Party A’s
approval, Party B shall not stop operation arbitrarily.

 

4.2.5 The contents of Party
B’s documents relating to this project shall conform to this Agreement.

 

4.2.6 Compile the near and
long-term investment plans for the development of construction waste cleaning, transport and recycling devices according to the
general urban plan and make investments at due time.

 

4.2.7 In order to perform
the obligations under this Agreement, Party B may use the rights and assets under the project of this Agreement as the guarantee
for loans provided that it shall obtain Party A’s approval in advance.

 

4.2.8 Perform other obligations
of laws, regulations and this Agreement.

 

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Chapter 5 Service Standards

 

5.1 Party B’s equipment,
facilities and techniques for the cleaning, transport and recycling of construction wastes must be scientific and advanced and
its activities must conform to relevant regulations and standards in the total process.

 

5.2 Party B must possess
the ability to satisfy the needs for timely cleaning, transport and recycling of urban construction wastes within the region and
period specified herein.

 

5.3 Party B must clean away
the construction wastes generated by nonprofit governmental activities according to Party A’s instructions. Party B shall
not refuse to clean or delay the cleaning work.

 

5.4 Party B shall be obligated
to clean away unclaimed construction wastes left by a third party in a timely manner according to Party A’s instructions.
Party B shall not refuse to clean or delay the cleaning work.

 

5.5 Party B must deliver
the construction wastes to its construction site for general disposal and pre-storage. Without Party A’s approval, Party
B shall not deposit and landfill them at any other place.

 

5.6 Before the cleaning
work, Party B must request relevant entity or individual to show the permit for construction waste cleaning, photocopy relevant
documentations substantiating cleaning of construction wastes and keep them on file for future reference (the documents shall be
kept for 10 years). Party B shall not clean the construction wastes if the documents approving cleaning of construction wastes
are not available. Without Party A’s approval, Party B shall not clean the construction wastes of which no document is available
to approve the cleaning thereof.

 

5.7 Before cleaning work,
Party B must apply with Party A for approval of the cleaning route and schedule. Party B must conduct the cleaning work strictly
according to the route and schedule approved by relevant authority.

 

5.8 Party B shall not subcontract
the cleaning work of construction wastes to a third party. For the construction wastes whose cleaning is already approved, Party
B shall organize the cleaning work in a timely and scientific manner. It is not allowed to affect the project progress due to
delay of the cleaning work.

 

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5.9 Party B’s cleaning
vehicles must be painted in a uniform color and with the uniform mark and code. The cleaning personnel shall wear a uniform which
needs to bear the identity text and logo of Party B where apparently visible. The cleaning vehicles must strictly observe the traffic
rules.

 

5.10 Party B must establish
flushing and drying equipment at the exit of loading and discharging site (place) of construction wastes to ensure the cleanness
of the wheels and body of the outbound vehicles and avoid pollution caused by falling mud, water and other pollutants.

 

5.11 The construction wastes
must be well covered during cleaning and transport. Over-height and overweight transport is forbidden. Do not dump or spill construction
wastes. In case of any over-height or overweight transport, dumping or spilling of construction wastes, Party B must take corrective
measures immediately.

 

5.12 It is necessary to
guarantee the proper use of the urban roads and public facilities administered by Party A during the cleaning. Avoid damages to
urban roads and public facilities.

 

5.13 Party B shall strengthen
maintenance, refitting and renovation of production facilities and equipment in a timely manner to ensure their soundness. Party
B shall strengthen management of production safety. During the concession period, Party B shall be liable for all safety accidents.

 

Chapter 6 Determination Method and Standard
and Adjustment Procedure of Charges

 

6.1 The construction waste
cleaning expenses collected by Party B must be determined through negotiations with the client according to market principles within
the scope of government-guided prices.

 

6.2 Where the government-guided
prices need to be adjusted, Party B shall file an application and Party A shall then propose to relevant authority for adjustment
of prices according to the prescribed procedure.

 

6.3 Party A has the right
to supervise Party B’s operating costs and evaluate Party B’s operations.

 

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Chapter 7 Performance Guarantee Letter

 

7. Performance Guarantee
Letter

 

7.1 As the guarantee for Party B’s
performance of the obligations stipulated in this Agreement, Party B shall submit a valid performance guarantee letter to Party
A within 30 days after the signing of this Agreement.

 

7.2 The performance guarantee letter
shall be issued by a financial institution recognized by Party A.

 

7.3 The issuer of the performance guarantee
letter shall specify “upon receiving Party A’s payment notice, payment shall be made unconditionally” in the
guarantee letter.

 

7.4 The guaranteed amount for the performance
guarantee letter is RMB 300,000 (in words: Three Hundred Thousand Yuan).

 

7.5 If the guaranteed amount of the
performance guarantee letter is withdrawn by Party A, Party A shall inform Party B in writing of the facts of Party B’s breach
and the withdrawn amount within 7 working days after making the withdrawal. Party B has the right to put up a defense against the
facts and reasons ascertained by Party A. If Party A deems that Party B’s defense is justified, it shall make rectification
promptly.

 

7.6 Party B shall, within 15 days after
receiving Party A’s written notice on the facts of the alleged breach and withdrawn amount, top up the account for guaranteed
amount to RMB 300,000 (in words: Three Hundred Thousand Yuan), and provide the relevant proof to Party A.

 

7.7 Party A’s exercise of the
right to withdraw liquidated damages shall not affect Party A’s exercise of other rights stipulated in this Agreement, and
it shall not waive off any other responsibilities and obligations that are to be borne by Party B toward Party A for non-performance
of this Agreement.

 

7.8The amount stipulated in the performance
guarantee letter shall be maintained at full amount until the expiry date of concession.

 

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Chapter 8 Operations of the Project

 

8. Operating Plan for the Project

 

8.1 Party B shall complete the building
of the construction waste treatment site within 3 months after signing this Agreement. It shall also complete the construction
of the project for recycled products obtained from construction waste treatment within 6 months, and achieve the normal operation
of the plant.

 

8.2 Within the concession period, all
the construction waste in the concession region shall, in principle, go to the site for treatment unless otherwise adjusted by
Party A.

 

8.3 Party A shall, according to the
relevant policies and within the scope of functions, assist Party B in promoting recycled products obtained from construction waste
treatment and enjoying the funding policies for the national project for recycled products obtained from construction waste treatment.

 

Chapter 9 Termination and Dissolution of
Concession

 

9.1 Termination upon Expiration

 

9.1.1If both parties do not reach a
consensus through negotiation on the extension of concession prior to the expiration of the concession period, the concession shall
be terminated automatically.

 

9.1.2Where Party B has the intention
to extend the concession period within two years before the expiration of the concession period, it may submit a request to Party
A. Under the same conditions, Party B is given priority to extend the concession period.

 

9.1.3During the concession
period, this Agreement can be terminated when both parties reach a consensus through negotiation.

 

9.2 Dissolution
by Party A

 

9.2.1Where Party B does not fulfill
or does not completely fulfill the obligations stipulated in this Agreement, and Party B still does not take the corresponding
corrective measures within 5 days after receiving Party A’s notice demanding for rectification within a given deadline,
Party A shall have the right to terminate Party B’s concession and dissolve this Agreement prematurely.

 

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9.2.2Where Party B should expand promptly
when its production capacity is unable to meet the urban development needs, but it fails to do so.

 

9.2.3Where Party A dissolves this Agreement
due to Party B’s breach of contract, Party B shall bear all consequences.

 

9.3 Dissolution
by Party B

 

9.3.1 During the concession period,
if Party A commits a serious violation of the obligations stipulated in this Agreement, and it still does not take the corresponding
corrective measures within 90 days after receiving Party B’s performance reminder notice, Party B shall have the right to
dissolve this Agreement.

 

9.3.2Within 60 days after Party B submits
the written notice for the dissolution of this Agreement to Party A, both parties shall negotiate the matters related to the dissolution
of this Agreement.

 

9.3.3Within the 60-day negotiation
period, Party B shall perform the waste removal and treatment obligations as per normal.

 

Chapter 10 Liabilities for Breach of Contract

 

10.1 Party A’s
Liabilities for Breach of Contract

 

10.1.1Where Party A unduly dissolves
Party B’s concession in breach of the concession dissolution conditions stipulated in this Agreement, and this causes Party
B to suffer property losses, it shall provide the corresponding compensation.

 

10.1.2If there is a particular sequence
of conduct for the fulfillment of obligations stipulated in this Agreement, and Party A fails to fulfill the earlier obligations
in accordance with the stipulations of this Agreement, Party B shall have the right to refuse to perform the subsequent obligations,
but Party B shall clearly express the reasons for not fulfilling the subsequent obligations to Party A.

 

10.2 Party B’s Liabilities for
Breach of Contract

 

Where Party B commits the following breach
of obligations stipulated in this Agreement and does not take corrective measures promptly even though it is able to do so, it
shall pay liquidated damages of 200 Yuan to Party A for each offence; where the breach is continuous or the consequences of the
breach are continuous, and Party A has ordered Party B to rectify within a deadline but Party B has not done so within a reasonable
deadline, it shall pay liquidated damages of 2000 Yuan per day to Party A. If Party B passes the deadline for 5 days, Party A may
dissolve this Agreement unilaterally.

 

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10.2.1 The removal vehicle is bare,
exceeds the height or weight limits, and discards or spills construction waste, and corrective measures are not taken promptly;

 

10.2.2The wheels and body of vehicles
on the road are dirty and messy, and the vehicles are driven with mud, water and other dirt, and corrective measures are not promptly
taken;

 

10.2.3 The construction waste is dumped
or buried outside Party B’s treatment and storage site for recycling or at sites that are not specified by Party A, and corrective
measures are not promptly taken;

 

10.2.4For construction waste generated
from the government’s charitable events or arbitrary dumping by third parties, or construction waste without an owner, the
prompt removal instructions given by Party A are not executed, and removal is not done or delayed unduly;

 

10.2.5The removal prices are raised
and the business is monopolized using the concession advantage, and corrective measures are not promptly taken;

 

10.2.6The construction waste removal
matters are subcontracted to unqualified third party for removal or treatment, and corrective measures are not promptly taken;

 

10.2.7The relevant regulations, specifications
and standards are not adhered to during the entire process or certain stages of construction waste removal and recycling treatment,
and corrective measures are not promptly taken;

 

10.2.8Construction waste, for which
the formalities have been completed, cannot be removed in a prompt, logical and organized manner, and this affects the progress
of the construction project site;

 

10.2.9Arbitrary work stoppage or suspension;\

 

10.2.10 The corresponding
repair, replacement and other such measures are not promptly carried out in a proactive manner or according to Party A’s
instructions when the urban roads and other public amenities are damaged during the removal process;

 

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10.2.11 The concession
is arbitrarily transferred, placed on mortgage, split, lent or leased to others, and corrective measures are not promptly taken;

 

10.2.12 The registered
capital, vehicles and equipment are withdrawn, and this removes Party B’s eligibility for the concession, and the corresponding
corrective measures are not promptly taken;

 

10.2.13 The reporting,
filing and other such obligations stipulated in this Agreement are not fulfilled;

 

10.2.14 Other conduct
that violates the obligations stipulated in this Agreement.

 

10.3 If Party B’s concessionary
operating capacity is unable to meet the demand for the prompt removal and recycling treatment of construction waste in the region
stipulated in this Agreement, and this is not rectified despite Party A’s reminder, Party A may, besides having the right
to dissolve this Agreement, take the measure to allow a third party to carry out the removal and recycling treatment of construction
waste.

 

10.4 Party A may, in accordance with
the stipulations of this Agreement, directly withdraw Party B’s liquidated damages from the account specified in the performance
guarantee letter provided by Party B.

 

Chapter 11 Resolution of Disputes

 

11. Resolution of Disputes

 

In the event of a dispute on this Agreement,
both parties shall negotiate a resolution; where a consensus cannot be reached through negotiation, both parties agree to bring
the dispute to Pingdingshan Arbitration Committee for arbitration.

 

Chapter 12 Confidential of Documents

 

12. Confidentiality of Documents

 

All parties must maintain the confidentiality
of data, information and documents of the other party or related to the other party’s interests obtained during the performance
of this Agreement, except when the other party clearly expresses that the data, information or document can be made open. The
confidentiality period shall extend until 2 years after the expiration of the term of agreement, except for the situations below.

 

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		(1)	Information that has been published or obtained openly by means other than this Agreement;
	 	 	 

		(2)	Information obtained by means that do not violate the confidentiality obligations;
	 	 	 

		(3)	Information obtained from a third party by means that do not violate the confidentiality obligations;
	 	 	 

		(4)	Information that is to be disclosed or made open according to the requirement of laws and regulations;
	 	 	 

		(5)	Disclosure made in order to fulfill one party’s obligations stipulated in this Agreement.

 

Chapter 13 Notification Address

 

13. Notification
Address

 

All notification related
to this Agreement shall be made in Chinese written form, and they shall be sent by hand, registered mail or fax to the following
addresses:

 

	
        Party A’s address:

        Telephone:

        Postal code:
	
         

        Fax:

	 	 
	Party B’s address: [handwritten:] East Wing, Xihuan Road, Xinhua district, Pingdingshan City (Pingdingshan Hengji Concrete Co., Ltd.)
	 
	
        Telephone: [handwritten:] 0375-2336789

         

        Postal code: [handwritten:] 467000
	Fax: [handwritten:] 0375-2204188

 

Chapter 14 Other Provisions

 

14. Other Provisions

 

14.1 For matters that are not addressed
in this Agreement, both parties shall separately negotiate and conclude a supplementary agreement. The supplementary agreement
and this Agreement shall have the same legal effect.

 

14.2This Agreement is executed in octuplicate
with both parties holding four copies each.

 

14.3 This Agreement shall take effect
on the day of signing.

 

    	- 15 -

    	 

    

 

	
        Party A: Pingdingshan Municipal Bureau
of Housing and Urban-Rural Development 

        
	 	
        Party B: Pingdingshan Xulong Renewable
Resource Co., Ltd.

	 	 	 
	(Affix Seal)	 	(Affix Seal)
	 	 	 
	[seal:] Pingdingshan Municipal Bureau of Housing
        and Urban-Rural Development	 	[seal:] Pingdingshan Xulong Renewable Resource
        Co., Ltd., 4104034000228
	 	 	 
	Agent (Signature): [signature:] Yang	 	Agent (Signature): [signature:] Zhu Yulong

 

[handwritten:] September 13, 2012

 

    	

    	 

    

 

	
        Party A: Pingdingshan Municipal Bureau
of Housing and Urban-Rural Development
	 	
        Party B: Pingdingshan Xulong Renewable
Resource Co., Ltd.

        

	 	 	 
	(Affix Seal)	 	(Affix Seal)
	 	 	 
	[seal:] Pingdingshan Municipal Bureau of Housing
        and Urban-Rural Development	 	[seal:] Pingdingshan Xulong Renewable Resource
        Co., Ltd., 4104034000228
	 	 	 
	Agent (Signature): [signature:] Yang	 	Agent (Signature): [signature:] Zhu Yulong

 

[handwritten:] September 13, 2012Exhibit 10.1
    

    

    

    

    

    
      First Amendment of
Option and License Agreement
    

    

    

    
      THIS FIRST AMENDMENT OF OPTION AND LICENSE AGREEMENT (the “Amendment”)
      is dated as of March 9, 2015 (the “Amendment Effective Date”)
      by and between Opexa Therapeutics, Inc., a corporation organized under
      the laws of Texas having a place of business at 2635 Technology Forest
      Boulevard, The Woodlands, TX 77381 (“Opexa”), and Ares
      Trading S.A., a corporation organized under the laws of Switzerland
      having a place of business at Zone Industrielle de l’Ouriettaz, 1170
      Aubonne, Switzerland (“Merck”).  Opexa and Merck may be
      referred to herein as a “Party” or, collectively, as “Parties.”
    

    
      RECITALS:
    

    
      WHEREAS, Opexa and Merck entered into an Option and License Agreement
      dated February 4, 2013 (“Option Agreement”) pursuant
      to which Opexa granted certain exclusive rights to Merck to develop and
      commercialize Opexa’s personalized T-cell immunotherapy (Tcelna®) in
      multiple sclerosis.
    

    
      WHEREAS, the Parties wish to amend the Option Agreement as provided in
      this Amendment;
    

    
      NOW, THEREFORE, it is mutually understood and agreed by and between the
      Parties as follows:
    

    
      Article 1
AMENDMENT OF THE OPTION AGREEMENT
    

    
      1.1      Effective upon the Amendment Effective Date, the Option
      Agreement is amended as provided in this Article 1.  Except as expressly
      modified in this Article 1, all provisions of the Option Agreement shall
      remain in full
           force and effect.
    

    
      1.2      Any capitalized term not otherwise defined herein shall
      have the same meaning as defined in the Option Agreement.
    

    
      1.3      Article 2 of the Option Agreement is amended by adding
      the following new Sections immediately following Section 2.3 thereof:
    

    
      2.4       Creation of Pre-Phase III Plan.  
      Commencing on March 15, 2015, Opexa will create a detailed plan,
      including a GANTT chart containing key tasks, decision points, timing,
      budget and milestones, documenting all of the activities necessary for
      laboratory facilities both in the U.S. and Europe to reach operational
      readiness by the end of December 2016 (such plan, the “Pre-Phase
      III Plan”).  The Pre-Phase III Plan will include, among other items,
      (i) review and identification of a preferred contract manufacturing
      organization in Europe, (ii) set-up, identification and qualification of
      third parties for raw materials, (iii) validation of laboratory
      facilities in the U.S. and Europe; and (iv) a hiring plan for the key
      personnel to complete the Pre-Phase III Plan. For Europe, the Pre-Phase
      III Plan will address the creation of a dedicated lab to support a Phase
      III trial.  For the US, the Pre-Phase III Plan will address the
      expansion of existing capabilities and infrastructure to handle a Phase
      III trial.
    

    
      
        

        

      

      
        

        

        
          

        

      

      
        

        

      

    

    
      2.5       Approval of Pre-Phase III Plan.  Opexa
      will present its proposed Pre-Phase III Plan to the JSC and the JSC
      shall review the proposed Pre-Phase III Plan.  The Pre-Phase III Plan
      shall be subject to the approval of the JSC, which approval shall not be
      unreasonably withheld or delayed.
    

    
      2.6       Pre-Phase III Plan and Extension of Option Period.  Notwithstanding
      anything to the contrary in Section 2.1, in the event that the JSC has
      not approved the Pre-Phase III Plan prior to end of the Option Period,
      the Option Period shall be extended, and Merck may exercise the Option,
      until sixty (60) days following the approval of the Pre-Phase III Plan
      by the JSC.
    

    
      2.7       R&D Funding Payment.  As
      consideration in advance of Opexa’s creation and performance of the
      Pre-Phase III Plan as well as Opexa’s performance of Section 2.8, Merck
      will pay to Opexa the sum of U.S. Three Million Dollars ($3,000,000)
      (the “R&D Funding Payment”), which sum shall be payable
      within fourteen (14) days of Merck’s receipt of an invoice from Opexa
      for the R&D Funding Payment.  For clarity, Opexa may submit such invoice
      on or after March 9, 2015.
    

    
      2.8       Immune Monitoring Data.  Opexa
      will provide to Merck updates and analysis on a blinded basis, grouped
      in patient batches according to Opexa’s analysis timetable, on the
      progress of Opexa’s immune monitoring program (the “Program”)
      being conducted in conjunction with the Abili-T Trial, with such updates
      and analysis to be shared by Opexa with Merck within thirty (30) days of
      Opexa’s initial assessment of such information.  Opexa will inform Merck
      of any existing or future external bioinformatics vendor used by Opexa
      for the Program, and Merck will have the right, at its expense, to
      review current and future data storage and integrity measures for the
      Abili-T Trial.
    

    
      1.4      Section 3.1 of the Option Agreement is amended by adding the
      following sentence immediately following the last sentence thereof:
    

    
      In addition to the foregoing responsibilities, the JSC shall also have
      responsibility for approving, and overseeing the completion by Opexa, of
      the Pre-Phase III Plan.  The JSC will meet at least quarterly beginning
      in the second (2nd) quarter of 2015 to advise and make
      specific recommendations with respect to the Pre-Phase III Plan,
      although the foregoing responsibility of the JSC shall not modify
      decision-making under Section 3.4 hereof.
    

    
      Article 2
ELECTRONIC EXECUTION
    

    
      2.1       This Amendment may be executed by the Parties by
      electronic means, by exchanging signed PDF copies that are scanned and
      emailed, and shall come into effect immediately upon execution by the
      last Party.
    

    
      
        

        

      

      
        
          2
        

        
          

        

      

      
        

        

      

    

    

    

    
      Article 3
RELATIONSHIP OF THE AMENDMENT WITH THE OPTION AGREEMENT
    

    
      3.1       The terms and conditions of this Amendment shall
      constitute a part of the Option Agreement as amended hereby, and shall
      be construed in accordance with the terms and conditions of the Option
      Agreement as amended.
    

    
      3.2       Except as expressly modified by this Amendment, the
      Option Agreement shall continue in fall force and effect.
    

    
      3.3       If there is a conflict between the Option Agreement and
      this Amendment, this Amendment shall prevail.
    

    
      [SIGNATURE PAGE FOLLOWS]
    

    
      
        

        

      

      
        
          3
        

        
          

        

      

      
        

        

      

    

    

    

    
      IN WITNESS WHEREOF, the Parties have caused this Agreement to be
      executed and delivered by their respective duly authorized officers as
      of the Effective Date.
    

    	
          
            Opexa Therapeutics, Inc.
          

        	
           
        	
          
            Ares Trading S.A.
          

        
	

        	

        	

        	

        	
           
        
	

        	

        	

        	

        	
           
        
	

        	

        	

        	

        	
           
        
	
          
            By:
          

        	
          
            /s/ Neil K. Warma
          

        	

        	
          
            By:
          

        	
          
            /s/ Cedric Hyde
          

        
	
          
            Name:
          

        	
          
            Neil K. Warma
          

        	

        	
          
            Name:
          

        	
          
            Cedric Hyde
          

        
	
          
            Title:
          

        	
          
            CEO
          

        	

        	
          
            Title:
          

        	
          
            Authorized Representative
          

        
	

        	

        	

        	

        	
           
        
	
          
            By:
          

        	
          
            /s/ Karthik Radhakrishnan
          

        	
          
             
          

        	
          
            By:
          

        	
          
            /s/ James Singleton
          

        
	
          
            Name:
          

        	
          
            Karthik Radhakrishnan
          

        	

        	
          
            Name:
          

        	
          
            James Singleton
          

        
	
          
            Title:
          

        	
          
            CFO
          

        	

        	
          
            Title:
          

        	
          
            Authorized Representative
          

        

    

    
      4

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