Document:

EXHIBIT 4.17

                                             As amended on April 26, 2001 by AGM

                                                                    Exhibit 4.17

                              HAEMACURE CORPORATION

                             1996 STOCK OPTION PLAN

SECTION 1 - PURPOSE OF THE PLAN

1.1 The purpose of this Stock Option Plan (the "Plan") is to provide directors,
officers and employees of, and service providers to, Haemacure Corporation (the
"Company") with a proprietary interest through the granting of options to
purchase Common Shares (the "Shares") of the Company, subject to certain
conditions as hereinafter set forth, for the following purposes:

1.1.1    to increase the interest in the Company's welfare of those directors,
         officers, employees and service providers who share primary
         responsibility for the management, growth and protection of the
         business of the Company;

1.1.2    to furnish an incentive to such senior  executives,  employees and
         service providers to continue their services for the Company; and

1.1.3 to provide a means through which the Company may attract able persons to
enter its employment.

1.2 For the purposes of the Plan, the term "service provider" shall mean any
person or company, other than an employee or insider of the Company or a
subsidiary thereof, engaged to provide ongoing management or consulting services
for the Company or for any entity controlled by it.

SECTION 2 - ADMINISTRATION OF THE PLAN

2.1     The Plan shall be administered by the Board of Directors of the Company.

2.2 The Board of Directors of the Company may, from time to time, adopt, amend
and rescind rules and regulations for carrying out the provisions and purposes
of the Plan, subject to regulatory approval. The interpretation, construction
and application of the Plan and any provisions thereof made by the Board of
Directors of the Company shall be final and conclusive. No director shall be
liable for any action taken or for any determination made in good faith in the
administration, interpretation, construction or application of the Plan.

SECTION 3 - GRANTING OF OPTIONS

3.1 The Board of Directors of the Company may from time to time by resolution
grant options to purchase Shares to directors, officers, employees of, and
service providers to, the Company, provided that the total number of Shares to
be issued under this Plan shall not exceed the number provided for in Section IV
hereof.
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3.2 Options may be granted by the Company pursuant to resolutions of the Board
of Directors only.

3.3 Any option granted under this Plan shall be subject to the requirement that,
if at any time, counsel to the company shall determine that the listing,
registration or qualification of the Shares subject to such option upon any
stock exchange or under any law or regulation of any jurisdiction, or the
consent or approval of any securities commission, stock exchange or any
governmental or regulatory authority or body, is necessary as a condition of, or
in connection with, the grant or exercise of such option or the issuance or
purchase of Shares hereunder, such option may not be accepted or exercised in
whole or in part unless such listing, registration, qualification, consent or
approval shall have been effected or obtained on conditions acceptable to the
Board of Directors.

SECTION 4 - SHARES SUBJECT TO THE PLAN

4.1 The maximum number of Shares which may be issued under this Plan is two
million four hundred twenty-three thousand two hundred and ninety-five
(2,423,295).

4.2 The aggregate number of Shares reserved for issuance to any one option,
whether under this Plan or any other share option plan, option for services or
share purchase plan of the Company, shall not exceed five percent (5%) of the
issued and outstanding Shares.

4.3 Shares in respect of which options are not exercised, due to the expiration,
termination or lapse of such options, shall be available for options to be
granted thereafter pursuant to the provisions of the Plan.

4.4 No option may be granted to any optionee hereunder if such grant could
result, at any time, when taken together with all of the Company's other share
compensation arrangements, in:

a)   the number of Shares reserved for issuance pursuant to stock options
     granted to Insiders exceeding 10% of the number of issued and outstanding
     Shares;

b)   the issuance to Insiders within a one-year period, of a number of Shares
     exceeding 10% of the number of issued and outstanding Shares; or

c)   the issuance to any one Insider and such Insider's associates, within a
     one-year period, of a number of Shares exceeding 5% of the number of issued
     and outstanding Shares.

         For the purposes of this section 4.4: (i) the term "Insider" shall have
the same meaning as in the Securities Act (Quebec); and (ii) the number of
issued and outstanding Shares shall be determined on the basis of the number of
Shares that are outstanding immediately prior to the share issuance in question,
excluding Shares issued pursuant to share compensation arrangements over the
preceding one-year period.

SECTION 5 - OPTION PRICE

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5.1 The option price per Share which is the subject of any option shall be fixed
by the Board of Directors of the Company at the time of granting the option. The
option price for the Shares shall not be less than the Market Price of the
Shares, as defined in section 5.2 hereof.

5.2 The term "Market Price" shall mean the greater of the closing sale prices of
the Shares on The Montreal Exchange and The Toronto Stock Exchange on the
business day immediately preceding the day on which the option is granted. In
the event that the Shares traded on only one of The Montreal Exchange and The
Toronto Stock Exchange on the said day, "Market Price" shall mean the closing
sale price of the Shares on the exchange on which the Shares traded on the
business day immediately preceding the day on which the option is granted. In
the event that the Shares did not trade on both of the Montreal Exchange and The
Toronto Stock Exchange on the said day, "Market Price" shall mean the simple
average of the average of the bid and ask prices in respect of the Shares on The
Montreal Exchange and The Toronto Stock Exchange at the close of trading on the
business day immediately preceding the day on which the option is granted. In
the event that the Shares are not listed or posted for trading on The Montreal
Exchange or The Toronto Stock Exchange, the "Market Price" shall be the fair
market value of the Shares as determined by the Board of Directors in its
discretion.

SECTION 6 - CONDITIONS GOVERNING OPTIONS

6.1      Each option shall be subject to the following conditions:

6.1.1    Employment

         The granting of an option to an officer or employee shall not impose
         upon the Company any obligation to retain the option in its employ.

6.1.2    Option Term

         The maximum period during which an option is exercisable shall be ten
         (10) years from the date the option is granted, after which the option
         shall lapse.

6.1.3    Non-assignability of Option Rights

         Each option granted hereunder is personal to the optionee and shall not
         be assignable or transferable by the optionee, whether voluntarily or
         by operation of law, except by will or by the laws of succession of the
         domicile of the deceased optionee. No option granted hereunder shall be
         pledged, hypothecated, charged, transferred, assigned or otherwise
         encumbered or disposed of on pain of nullity.

6.1.4    Other Terms

         The Board may at the time of granting options hereunder provide for
         additional terms and conditions which are not inconsistent with section
         6 hereof.

6.1.5.   Effect of Termination of Employment or office or Death

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          6.1.5.1   Upon an optionee's employment with the Company being
                    terminated for cause, any option not actually exercised
                    prior to the date of termination shall immediately lapse and
                    become null and void.

          6.1.5.2   If an optionee: (i) dies while employed by the Company or
                    while a director thereof; or (ii) if an optionee's
                    employment, office or directorship with the Company
                    terminates or ends otherwise than by reason of death or
                    termination for cause, any option or unexercised part
                    thereof granted to such optionee may be exercised: (a) by
                    the person to whom the option is transferred by will or the
                    laws of succession and distribution; or (b) by the optionee,
                    as the case may be, for that number of shares only which he
                    was entitled to acquire under the option at the time of his
                    death, termination, or end of employment, office or
                    directorship. Such option shall be exercisable within one
                    (1) year after the optionee's death, termination, or end of
                    employment, office or directorship, or prior to the
                    expiration of the term of the option, whichever occurs
                    earlier.

6.1.6    Rights as a Shareholder

         The optionee (or his personal representatives or legatees) shall have
         no rights whatsoever as a shareholder in respect of any Shares covered
         by his option until the date of issuance of a share certificate to him
         (or his personal representatives or legatees) for such Shares. Without
         in any way limiting the generality of the foregoing, no adjustment
         shall be made for share certificate is issued.

6.1.7    Method of Exercise

         Subject to the provisions of this Plan, an option granted under this
         Plan shall be exercisable by the optionee (or his personal
         representatives or legatees) giving notice in writing to the Transfer
         Agent and Registrar of the Company at its principal offices in
         Montreal, with a copy to the Secretary of the Company at its head
         office, which notice shall specify the number of Shares in respect of
         which the option is being exercised and shall be accompanied by full
         payment, by cash or certified cheque, of the purchase price for the
         number of shares specified. Upon such exercise of the option, the
         Company shall forthwith cause the transfer agent and registrar of the
         Shares of the Company to deliver to the optionee (or his personal
         representatives or legatees) a certificate in the name of the optionee
         representing in the aggregate such number of Shares as the optionee (or
         his personal representatives or legatees) shall have then paid for and
         as are specified in such written notice of exercise of option. If
         required by the Board of Directors by notification to the optionee, it
         shall be a condition of such exercise that the optionee shall represent
         that he is purchasing the Shares in respect of which the option is
         being exercised for investment only and not with a view to resale or
         distribution.

6.2 Options may be evidenced by a share option agreement, instrument or
certificate in such form not inconsistent with this Plan as the Board of
Directors may from time to time determine, provided that the substance of
Section 6.1 be included therein.

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SECTION 7 - ADJUSTMENT -TO SRARES SUBJECT TO THE OPTION

7.1 In the event of any subdivision of the Shares into a greater number of
Shares at any time after the grant of an option to any optionee and prior to the
expiration of the term of such option, the Company shall deliver to such
optionee at the time of any subsequent exercise of his option in accordance with
the terms hereof in lieu of the number of Shares to which he was theretofore
entitled upon such exercise, but for the same aggregate consideration payable
therefore, such number of Shares as such optionee would have held as a result of
such subdivision if on the record date thereof the optionee had been the
registered holder of the number of Shares to which he was theretofore entitled
upon such exercise.

7.2 In the event of any consolidation of the Shares into a lesser number of
Shares at any time after the grant of an option to any optionee and prior to the
expiration of the term of such option, the Company shall deliver to such
optionee at the time of any subsequent exercise of his option in accordance with
the terms hereof in lieu of the number of Shares to which he was theretofore
entitled upon such exercise, but for the same aggregate consideration payable
therefore, such number of Shares as such optionee would have held as a result of
such consolidation if on the record date thereof the optionee had been the
registered holder of the number of Shares to Which he was theretofore entitled
upon such exercise.

7.3 If at any time after the grant of an option to any optionee and prior to the
expiration of the term of such option, the Shares shall be reclassified,
reorganized or otherwise changed, otherwise than as specified in paragraphs 7.1
and 7.2 or, subject to the provisions of paragraph 8.2.1 hereof, the Company
shall consolidate, merge or amalgamate with or into another company (the
corporation resulting or continuing from such consolidation, merger or
amalgamation being herein called the "Successor Company"), the optionee shall be
entitled to receive upon the subsequent exercise of his option in accordance
with the terms hereof and shall accept in lieu of the number of Shares then
subscribed for but for the same aggregate consideration payable therefore, the
aggregate number of shares of the appropriate class and/or other securities of
the Company or the Successor Company (as the case may be) and/or other
consideration from the Company or the Successor Company (as the case may be)
that the optionee would have been entitled to receive as a result of such
reclassification, reorganization or other change of shares or, subject to the
provisions of paragraph 8.2.1 hereof, as a result of such consolidation, merger
or amalgamation, if on the record date of such reclassification, reorganization
or other change of shares or the effective date of such consolidation, merger or
amalgamation, as the case may be, he had been the registered holder of the
number of Shares to which he was immediately theretofore entitled upon such
exercise.

SECTION 8 - AMENDMENT OR DISCONTINUANCE OF THE PLAN

8.1 Subject to obtaining the necessary regulatory approvals, the Board of
Directors may amend or discontinue this Plan at any time, provided, however,
that no such amendment may adversely affect any option rights previously granted
to an optionee under this Plan without the consent of the optionee, except to
the extent required by law.

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8.2 Notwithstanding anything contained to the contrary in this Plan or in any
resolution of the Board of Directors in implementation thereof:

8.2.1    in the event the Company proposes to amalgamate, merge or consolidate
         with or into any other company (other than with a wholly-owned
         subsidiary of the Company) or to liquidate, dissolve or wind-up, or in
         the event an offer to purchase the Shares of the Company or any part
         thereof shall be made to all holders of Shares of the Company, the
         Company shall have the right, upon written notice thereof to each
         optionee holding options under this Plan, to permit the exercise of
         all such options within the 20-day period next following the date of
         such notice and to determine that upon the expiration of such 20-day
         period, all rights of optionees to such options or to exercise same
         (to the extent not theretofore exercised) shall terminate and cease to
         have further force or effect whatsoever;

8.2.2    the Board of Directors may, by resolution, advance the date on which
         any option may be exercised in a manner to be set forth in such
         resolution. The Board of Directors shall not, in the event of any such
         advancement, be under any obligation to advance the date on or by which
         any option may be exercised by any other optionee; and

8.2.3    the Board of Directors may, by resolution, but subject to applicable
         regulatory requirements, decide that any of the provisions hereof
         concerning the effect of termination for cause of the optionee's
         employment shall not apply for any reason acceptable to the Board of
         Directors.

SECTION 9 - EFFECTIVE DATE OF PLAN

         This Plan was adopted by the Board of Directors of Haemacure
Corporation on the 21st day of March, 1996.

                                       6EXHIBIT 4.18
                           LOAN AND SECURITY AGREEMENT

     PREAMBLE. THIS LOAN AND SECURITY AGREEMENT (as it may be amended or
modified from time to time, and together with all Schedules, Riders and Exhibits
attached hereto, this "Agreement") is made by UPS CAPITAL CORPORATION, a
Delaware corporation ("Lender"), with each undersigned "Borrower" (as more
particularly defined below, "Borrower") as of the "Closing Date" specified below
(the "Closing Date"), for the purpose of evidencing the terms and conditions on
which Lender will extend financing to Borrower.

     NOW, THEREFORE, to induce Lender to extend the financing provided for
herein, and for other good and valuable consideration, the sufficiency and
receipt of which are mutually acknowledged, Borrower agrees with Lender as
follows:

     1.   DEFINITIONS, TERMS AND REFERENCES

          1.1. Certain Definitions. In addition to such other terms as elsewhere
defined herein, as used in this Agreement and in any Exhibit or Schedule
attached hereto, the following terms shall have the following meanings:

     "Accounts Receivable Collateral" shall mean and include all accounts,
accounts receivable, contract rights, instruments, chattel paper and payment
intangibles of Borrower, including, without limitation, all rights of Borrower
to payment for goods sold or leased, or to be sold or to be leased, or for
services rendered or to be rendered, howsoever evidenced or incurred, together
with all returned or repossessed goods and all books, records, computer tapes,
programs and ledger books arising therefrom or relating thereto; all whether now
owned or hereafter acquired and howsoever arising.

     "Account Debtor" shall mean any Person who is obligated on any of the
Accounts Receivable Collateral or otherwise is obligated as a purchaser or
lessee of any of the Inventory Collateral.

     "Advance" shall mean an advance of borrowed funds made by Lender to
Borrower under the Line of Credit, provided however, that for purposes of
determining (A) the amount of any non-usage fee, (B) compliance with the
Borrowing Base Requirement, and (C) "Excess Borrowing Availability" under
Section 7.4, "Advances" shall include, without duplication: (1) the amount
available for drawing under each Letter of Credit, and (ii) all outstanding
Reimbursement Obligations. The term "Advance" shall not include, however, the
Special Advance.

     "Affiliate" shall mean, with respect to any specified Person, either: (i)
any Person, directly or indirectly, Controlling, Controlled by or under common
Control with, the specified Person, or (ii) any officer or director of such
specified Person.

     "Agreement" - See Preamble.

     "Applicable Margin" shall mean two and one-fourth of one percent (2 1/4%)
per annum.

     "Applicable Rate" shall mean the Prime Rate plus the Applicable Margin.

     "Assignment of Claims Act" shall mean the federal Assignment of Claims Act
of 1940, as it may be amended from time to time; together with all regulations
promulgated from time to time in respect thereof.

     "Balances Collateral" shall mean all moneys, securities and other property
and the proceeds thereof, now or hereafter held or received by, in transit to,
in possession of, or under the control of, Lender or a bailee or Affiliate of
Lender, from or for Borrower, whether for safekeeping, pledge, custody,
transmission, collection or otherwise, and all of Borrower's deposits (general
or special), balances, sums and credits with Lender at any time existing.

     "Bankruptcy Code" shall mean Title 11 of the United States Code, as it may
be amended from time to time.
<PAGE>

     "Blocked Account Agreement" shall have the meaning given to such term in
Section 2.3.4.

     "Booked Cost," in respect of Inventory Collateral, shall mean the inventory
cost accounting method employed by Borrower as of the Closing Date; provided,
however, that, notwithstanding the foregoing, for purposes of computing the
Borrowing Base, all such determinations of "Booked Cost" shall be made net of
the effect of any "transfer pricing" or similar arrangements made by Borrower
with Parent or any Affiliate in respect of inventory purchases on the actual
cost thereof (or, in lieu of the foregoing, Lender shall be entitled to impose a
reserve on the Borrowing Base equivalent to the impact on actual cost of any
such arrangements).

     "Borrower" shall mean each undersigned Person designated as "Borrower" on
the signature page(s) to this Agreement, as each is described more particularly
on the Borrower Information Schedule. If more than one Person is so identified
and described, then, the term "Borrower" shall mean each Person, jointly and
severally.

     "Borrower Information Schedule" shall mean Schedule "1" attached hereto, as
it may be modified or amended from time to time by mutual assent of the parties
hereto.

     "Borrowing Base" shall mean a sum equal to: (i) eighty-five percent (85%)
of the net dollar amount of Eligible Accounts as at the date of determination;
plus (ii) an amount not to exceed Two Million Dollars ($2,000,000), however,
equal to the sum (without duplication) of (A) fifty percent (50%), of the dollar
amount of that portion of any Eligible Inventory which is located at a
Collateral Location which is under Logistics Control, valued at the lower of its
Booked Cost or market value at the date of determination; plus (B) for a period
of sixty (60) days after the Closing Date, twenty-five percent (25%) of the
dollar amount of that portion of any Eligible Inventory which is located at a
Collateral Location which is not under Logistics Control, as described more
particularly in clause (viii) of the definition of "Eligible Inventory" set
forth below, but the total amount of borrowing availability derived from this
clause (B) shall not exceed Five Hundred Thousand Dollars ($500,000), i.e., the
product of twenty-five percent (25%) multiplied by Two Million Dollars
($2,000,000), which is the limitation described more particularly in the
aforesaid clause (viii), plus (C) if the Logistics Contract is terminated
subsequent to the Closing Date and such termination does not constitute an Event
of Default under Section 8.15 of this Agreement, then, beginning on that date
which is ninety (90) days after termination of the Logistics Contract, forty
percent (40%) of that portion of any Eligible Inventory which is located at a
Collateral Location not under Logistics Control, as described more particularly
in clause (viii) of the definition of "Eligible Inventory" set forth below (but
until that ninetieth (90th) day the advance rate shall remain at fifty percent
(50%), as provided in clause (A) above, and, during that ninety (90) day period,
Eligible Inventory need not be under Logistics Control in order to be subject to
the fifty percent (50%) advance rate), but the total amount of borrowing
availability derived from this clause (C) shall not exceed at any time in dollar
amount that portion of the Borrowing Base then and thereafter attributable to
Eligible Accounts only; minus (iii) such reserves against the Borrowing Base and
borrowing availability under the Line of Credit as Lender may elect to impose
from time to time in its good faith credit judgment, after giving at least ten
(10) days' advance notice to Borrower.

     "Borrowing Base Certificate" shall mean a certificate submitted by Borrower
to Lender demonstrating compliance with the Borrowing Base Requirement, which
report shall be substantially in the form of Exhibit "A".

     "Borrowing Base Requirement" shall have the meaning ascribed to such term
in Section 2.1.1.

     "Borrowings" shall mean total Advances outstanding from time to time.

     "Business Day" shall mean a day on which Lender is open for the conduct of
its business at its principal office in Atlanta, Georgia.

     "Clearing Bank" shall have the meaning given to such term in Section 2.3.4.

     "Closing Date" shall mean the date specified in the signature page of this
Agreement as the Closing Date.

     "Collateral" shall have the meaning given to such term in Section 3.

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     "Collateral Location" shall mean the Executive Office and each additional
location, if any, set forth and described as such on the Borrower Information
Schedule.

     "Collateral Status Certificate" shall mean a certificate, to be
substantially in the form of Exhibit "B" attached hereto, submitted by Borrower,
reflecting the status of the Collateral.

     "Collection Days" shall mean two (2) Business Days.

     "Compliance Certificate" shall mean a certificate, to be substantially in
the form of Exhibit "C" attached hereto, issued by a duly authorized officer of
Borrower, confirming Borrower's continuing compliance with this Agreement.

     "Consolidated Subsidiaries" shall mean those Subsidiaries of Borrower (if
any) existing from time to time which, for purposes of GAAP, are required to be
consolidated for financial reporting purposes.

     "Control," "Controlled" or "Controlling" shall mean, with respect to any
Person, the power to direct the management and policies of such Person,
directly, indirectly, whether through the ownership of voting securities or
otherwise.

     "Debt" means all liabilities, obligations and indebtedness of a Person, of
any kind or nature, whether now or hereafter owing, arising, due or payable,
howsoever evidenced, created, incurred, acquired or owing, whether primary,
secondary, direct, contingent, fixed or otherwise, and whether initiated,
assumed or acquired by such Person.

     "Default Condition" shall mean the occurrence of any event which, after
satisfaction of any requirement for the giving of notice or the lapse of time,
or both, would become an Event of Default.

     "Default Rate" shall mean that interest rate per annum equal to three
percent (3%) per annum in excess of the otherwise Applicable Rate payable on any
Obligation.

     "Dollars" or "$" shall mean United States Dollars; and "CDN" shall mean
Canadian Dollars.

     "Eligible Accounts" shall mean that portion of Borrower's Accounts
Receivable Collateral consisting of trade accounts receivable actually billed
to, and owing to Borrower by, its Account Debtors in the ordinary course of its
business, excluding, however, in any event, any such account: (i) with respect
to which any portion thereof is more than ninety (90) days past invoice date;
(ii) which is owing by any Affiliate of Borrower; (iii) which is owing by any
Account Debtor having fifty percent (50%) or more in face value of its then
existing accounts with Borrower ineligible hereunder pursuant to the operation
and effect of clause (i) above; (iv) which arises from any contract on which
Borrower's performance is assured by a performance, completion or other bond;
(v) constituting retainage which has been withheld from Borrower pending
contract completion, to the extent thereof; (vi) constituting a service,
warranty or similar charge, to the extent thereof; (vii) which is evidenced by a
promissory note, other instrument or chattel paper; (viii) which represents an
accord and satisfaction in respect of any prior account receivable; (ix) the
assignment of which is subject to any requirements set forth in the Assignment
of Claims Act (unless and except to the extent that Borrower has complied
therewith to Lender's satisfaction); (x) which does not conform in any respect
to the warranties and representations set forth in the Loan Documents in respect
of Accounts Receivable Collateral; (xi) which is owing by any Account Debtor
whose accounts in face amount with Borrower exceed twenty percent (20%) of
Borrower's Eligible Accounts, but only to the extent of such excess; (xii) which
is owing by, billed to or paid by any Account Debtor not located in the United
States of America (unless and except to the extent that it is backed by a letter
of credit issued to Borrower as beneficiary by or through a bank headquartered
in the United States which is acceptable to Lender); (xiii) as to which a duly
perfected, first priority security interest does not exist at any time in favor
of Lender; (xiv) as to which any counterclaim, defense, setoff, deduction or
contra-account exists, to the extent thereof; or (xv) which has otherwise been
determined by Lender in its good faith credit judgment not to be an "Eligible
Account" for purposes hereof.

     "Eligible Inventory" shall mean that portion of the Inventory Collateral
consisting of new, saleable finished goods inventory of Borrower, which (i) is
at all times subject to a duly perfected, first priority security interest in

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favor of Lender; (ii) is in good and saleable condition which, without
limitation, in the case of Immuno Licensed Products, shall include ongoing FDA
Approval; (iii) is not on consignment to or from any Person, and is not
otherwise subject to, any repurchase agreement with any customer or supplier;
(iv) does not constitute returned, repossessed, damaged or slow-moving goods;
(v) conforms in all respects to the warranties and representations set forth in
the Loan Documents in respect of Inventory Collateral; (vi) is not subject to a
negotiable document of title (unless issued or endorsed to Lender); (vii) except
as set forth in Section 4.11 and in the Immuno License, is not subject to any
license or other agreement that limits or restricts Lender's right to sell or
otherwise dispose of such inventory; (viii) is located only at a Collateral
Location which is under Logistics Control; provided, however, that,
notwithstanding the foregoing, (A) for a period not to exceed sixty (60) days
after the Closing Date, Inventory Collateral not at a Collateral Location under
Logistics Control shall not be declared ineligible solely by virtue of this
clause (viii), but the total amount of such Inventory Collateral not under
Logistics Control which may be Eligible Inventory hereunder shall not exceed Two
Million Dollars ($2,000,000), and the advance rate thereon, for purposes of
determining the Borrowing Base, shall be reduced from fifty percent (50%) to
twenty-five percent (25%), as is described more particularly in clause (ii)(B)
of the definition of "Borrowing Base" hereinabove and (B) if the Logistics
Contract is terminated and such termination does not constitute an Event of
Default under Section 8.15 of this Agreement, then, Inventory Collateral not
under Logistics Control shall not be declared to be ineligible under this clause
(viii), but, beginning on that date which is ninety (90) days after termination
of the Logistics Contract, the total amount of such Inventory Collateral not
under Logistics Control which may be Eligible Inventory hereunder shall not
exceed at any time in dollar amount that portion of the Borrowing Base then and
thereafter attributable to Eligible Accounts only, and the advance rate thereon,
for purposes of determining the Borrowing Base, shall be reduced from fifty
percent (50%) to forty percent (40%), as is described more particularly in
clause (ii)(C) of the definition of "Borrowing Base" hereinabove; (ix) is
located at any Collateral Location (including any housing Inventory Collateral
under Logistics Control) with respect to which, if leased by Borrower or
Logistics (as the case may be) Lender has received from the landlord at such
location a Landlord's Agreement, and (x) has not otherwise been determined by
Lender in its good faith credit judgment not to be "Eligible Inventory" for
purposes hereof.

     "Equipment Collateral" shall mean all equipment and fixtures of Borrower,
whether now owned or hereafter acquired, wherever located in the United States,
including, without limitation, all machinery, furniture, furnishings, leasehold
improvements, computer hardware, motor vehicles, forklifts, rolling stock, dies
and tools used or useful in Borrower's business operations.

     "Equity Interests" shall mean all capital stock, warrants and other
securities evidencing ownership of equity interests in a Person. In the case of
(i) a partnership, the foregoing includes partnership interests or shares; and
(ii) a limited liability company, the foregoing includes members' interests or
shares.

     "Event of Default" shall mean any of the events or conditions described in
Article 8, provided that any requirement for the giving of notice or the lapse
of time, or both, has been satisfied.

     "Executive Office" shall mean the address of Borrower's chief executive
office and principal place of business, as designated on the Borrower
Information Schedule.

     "Existing Lender" shall mean Heller Healthcare Finance, Inc., to which
Borrower is indebted on the Closing Date pursuant to the Existing Lender
Agreement, which Debt is being refinanced pursuant hereto.

     "Existing Lender Agreement" shall mean the loan and security agreement,
dated prior to the Closing Date, among Parent, Borrower and the Existing Lender,
as amended or modified through the Closing Date.

     "FDA" shall mean the United States Food and Drug Administration.

     "FDA Approval" shall mean the continuing approval of the FDA to manufacture
and sell the Immuno Licensed Products in the United States of America.

     "Fiscal Year", in respect of a Person, shall mean the fiscal year of such
Person, as employed by such Person as of the Closing Date, and designated as
such on the Borrower Information Schedule, as to Parent and Borrower. The terms
"Fiscal Quarter" and "Fiscal Month" shall correspond accordingly thereto.

                                       4
<PAGE>

     "GAAP" shall mean Canadian generally accepted accounting principles
consistently applied for the fiscal period(s) in question, whether applied in
respect of Borrower or the Parent.

     "Guaranty" shall mean any agreement or other writing executed by a
Guarantor guaranteeing payment of any of the Obligations or otherwise giving
assurances to Lender in respect thereof. Unless otherwise accepted or requested
by Lender, each Guaranty shall be substantially in the form of Exhibit "D"
attached hereto.

     "Guarantor" shall mean, individually and collectively, any and all Persons
who either, as of the Closing Date, or thereafter, join in the execution of any
Guaranty. As of the Closing Date, the Parent is the only Guarantor.

     "Home State" shall mean the State in which Borrower is incorporated or
otherwise organized (if Borrower is not a corporation), as set forth on the
Borrower Information Schedule.

     "Immuno License" shall mean the perpetual license, among other things, to
manufacture and sell a biological fibrin sealant product approved by the U.S.
Food and Drug Administration, and a frozen formulation of said product, granted
by Immuno International, AG, a Swiss corporation, as licensor, to Parent, as
licensee, pursuant to a license agreement, dated as of April 21, 1997, made
between said parties, as such agreement has been modified or amended through the
Closing Date and as it may be further modified or amended from time to time in
the future.

     "Immuno Licensed Products" shall mean products manufactured and/or
distributed by Borrower pursuant to the Immuno License.

     "Initial Term" shall mean a period of three (3) years, ending on the third
(3d) anniversary of the Closing Date.

     "IP Assignments" has the meaning given to such term in Section 5.2.

     "Insolvent", in respect of a Person, shall mean that (i) such Person is not
able to pay its Debts generally as and when they become due; or (ii) such Person
has an unreasonably small capital with which to operate; or (iii) the total
Debts and other liabilities of such Person, including contingent liabilities,
exceed the fair saleable value of the assets of such Person.

     "Intangibles Collateral" shall mean all general intangibles of Borrower,
whether now existing or hereafter acquired or arising, including, without
limitation, all copyrights, royalties, tax refunds, rights to tax refunds,
trademarks, trade names, service marks, patent and proprietary right and trade
secrets; all computer software and programs; and all rights of Borrower as
purchaser, lessee, licensee or indemnitee under any contract, excepting
therefrom any portion thereof represented by contracts containing legally
enforceable restrictions on the granting of security interests therein by
Borrower to the extent of such restrictions, and so long as such restrictions
shall be effective.

     "Inventory Collateral" shall mean all inventory of Borrower, whether now
owned or hereafter acquired, wherever located, including, without limitation,
all goods of Borrower held for sale or lease or furnished or to be furnished
under contracts of service, all goods held for display or demonstration, goods
on lease or consignment, spare parts, repair parts, returned and repossessed
goods, all raw materials, work-in-process, finished goods, catalysts and
supplies used or consumed in Borrower's business, together with all documents,
documents of title, dock warrants, dock receipts, warehouse receipts, bills of
lading or orders for the delivery of all, or any portion, of the foregoing. The
term "Inventory Collateral" shall include, without limitation, all Immuno
Licensed Products owned by Borrower at any time or from time to time.

     "Landlord's Agreement" shall mean an agreement from the landlord of any
Collateral Location pursuant to which such landlord has waived, released or
subordinated in favor of Lender any rights it has in respect of the Collateral,
to be substantially in the form of Exhibit "F" attached hereto (unless otherwise
required or approved by Lender).

     "Lender" - See Preamble.

                                       5
<PAGE>

     "Letter of Credit" shall have the mean given to such term in Section 2.1.2.

     "Lien" shall mean any deed to secure debt, deed of trust, mortgage or
similar instrument, and any lien, security interest, preferential arrangement
which has the practical effect of constituting a security interest, security
title, pledge, charge, encumbrance or servitude of any kind, whether by
consensual agreement or by operation of statute or other law, and whether
voluntary or involuntary, including, without limitation, any conditional sale or
other title retention agreement or lease in the nature thereof.

     "Line of Credit" shall refer to the line of credit in the Maximum Amount
opened by Lender in favor of Borrower pursuant to the provisions of Section 2.1.

     "Loan Documents" shall mean this Agreement, the Master Note, any IP
Assignments, any financing statements covering portions of the Collateral, and
any and all other documents, instruments, certificates and agreements executed
and/or delivered by Borrower in connection herewith, or any one, more, or all of
the foregoing, as the context shall require.

     "Lockbox Accounts" shall have the meaning given to such term in Section
2.3.4.

     "Logistics" shall mean Livingston Healthcare Services, Inc.; and its
successors and assigns.

     "Logistics Contract" shall mean that certain Warehouse Services Agreement,
dated on or about the Closing Date, made between Logistics and Borrower,
pursuant to which Logistics shall provide certain warehousing and logistics
services to Borrower over the Initial Term; as such contract may be modified,
amended or extended from time to time.

     "Logistics Control" shall mean possession and control of Inventory
Collateral by Logistics at one or more warehouses owned and/or operated by
Logistics, all pursuant to the Logistics Contract.

     "Master Note" shall mean the master promissory note, dated of even date
herewith, as amended or supplemented from time to time, in a principal amount
equal to the maximum amount of the Line of Credit, evidencing Advances to be
obtained by Borrower under the Line of Credit, together with any renewals or
extensions thereof in whole or in part. The Master Note shall be substantially
in the form of Exhibit "G".

     "Material Adverse Change" shall mean any event, act, condition or
occurrence of whatever nature (including any adverse determination in any
litigation, arbitration or governmental investigation or proceeding), whether
singly or in conjunction with any other event or events, act or acts, condition
or conditions, occurrence or occurrences, whether or not related, representing a
material adverse change in, or a material adverse effect upon, any of (a) the
financial condition, operations, business, properties or prospects of the
Borrower and its Consolidated Subsidiaries, taken as a whole, (b) the rights and
remedies of the Lender under any of the Loan Documents or the ability of the
Borrower to perform its obligations under any of the Loan Documents, or (c) the
legality, validity or enforceability of any of the Loan Documents.

     "Materiality Threshold" shall mean Two Hundred Thousand Dollars ($200,000).

     "Maximum Amount" shall mean the maximum amount which is available for
borrowing under the Line of Credit (determined without regard to the Borrowing
Base Requirement), which, as of the Closing Date, is equal to Six Million
Dollars ($6,000,000).

     "Note" shall mean any instrument at any time evidencing all or any portion
of any Obligations, including, particularly, the Master Note.

     "Notice of Borrowing" shall mean a notice of intended Borrowing, executed
by a duly authorized officer of Borrower, in substantially the form of Exhibit
"H".

                                       6
<PAGE>

     "Obligations" shall mean any and all Debts of Borrower to Lender (or any
Affiliate of Lender), including, without limiting the generality of the
foregoing, any Debt of Borrower to Lender (or any Affiliate of Lender) under any
loan made to Borrower by Lender prior to the date hereof and any and all
extensions or renewals thereof in whole or in part; any Debt of Borrower to
Lender arising hereunder or as a result hereof, whether evidenced by any Note,
or constituting Advances, the Special Advance or otherwise, including all
Reimbursement Obligations, and any and all extensions or renewals thereof in
whole or in part; any Debt of Borrower to Lender (or any Affiliate of Lender)
under any later or future advances or loans made by Lender (or any Affiliate of
Lender) to Borrower, and any and all extensions or renewals thereof in whole or
in part; and any and all future or additional Debts of Borrower to Lender (or
any Affiliate of Lender) whatsoever and in any event, whether existing as of the
date hereof or hereafter arising, whether arising under a loan, lease, credit
card arrangement, line of credit, letter of credit or other type of financing,
whether initiated, assumed or acquired by Lender, and whether direct, indirect,
absolute or contingent, as maker, endorser, guarantor, surety or otherwise,
howsoever evidenced.

     "Organization Documents" shall mean the formation and governing documents
of a Person, as applicable. In the case of (i) a corporation, the foregoing
shall include its charter and bylaws; (ii) a partnership, the foregoing shall
include its partnership agreement; and (iii) a limited liability company, the
foregoing shall include its operating agreement.

     "Parent" shall mean Haemacure Corporation (Canada), a Canadian corporation
and sole shareholder of Borrower.

     "Parent Debt" shall mean all Debt of Borrower to Parent existing on, or
subsequent to, the Closing Date.

     "Permitted Encumbrances" shall mean: (i) Liens for taxes not yet due and
payable or being actively contested as permitted by this Agreement, but only if
such Liens do not adversely affect Lender's rights or the priority of Lender's
security interest in the Collateral; (ii) carriers', warehousemen's, mechanics',
materialmen's, repairmen's or other like Liens arising in the ordinary course of
business, payment for which is not yet due or which are being actively contested
in good faith and by appropriate, lawful proceedings, but only if such liens are
and remain junior to liens granted in favor of Lender; (iii) pledges or deposits
in connection with worker's compensation, unemployment insurance and other
social security legislation; (iv) deposits to secure the performance of
utilities, leases, statutory obligations and surety and appeal bonds and other
obligations of a like nature arising by statute or under customary terms
regarding depository relationships on deposits held by financial institutions
with whom Borrower has a banker-customer relationship; (vi) typical restrictions
imposed by licenses and leases of software (including location and transfer
restrictions); (vii) Liens in favor of Lender; and (viii) Liens granted by
Borrower or any Subsidiary to vendors or financiers of capital assets to secure
the payment of Purchase Money Debt so long as (A) such Debt is permitted to be
incurred hereunder, (B) such Liens extend only to the specific assets so
purchased, secure only such deferred payment obligation and related interest,
fees and charges and no other Debt, and (C) such Liens are promptly released
upon the payment in full of such Debt.

     "Person" shall mean any individual, partnership, corporation, limited
liability company, joint venture, joint stock company, trust, governmental unit
or other entity.

     "Prime Rate" shall mean the interest rate published under the "Money Rates"
section of The Wall Street Journal (on each day on which it is published) as the
"prime rate" on such day, as such rate may change from time to time; provided,
however, that if The Wall Street Journal shall cease to publish such rate (or
itself to be published); then, the "Prime Rate" shall be the highest among the
prime or base rates then publicly announced by Bank of America, N.A., Chase
Manhattan Bank and First Union National Bank (or their respective
successors-in-interest).

     "Purchase Money Debt" shall mean Debt incurred by Borrower or any
Subsidiary in connection with the acquisition of capital assets for the cost
thereof (including any for the deferred payment of any purchase price).

     "Reimbursement Obligations" has the meaning given to such term in Section
2.1.2.

     "Special Advance" shall mean the special advance made pursuant to Section
2.1.3 on the Closing Date.

                                       7
<PAGE>

     "Subordinated Debt" shall mean the Parent Debt, to the extent subordinated
to the Obligations pursuant to the Subordination Agreement.

     "Subordination Agreement" shall mean an agreement between or among
Borrower, Lender and Parent pursuant to which Parent shall agree to subordinate
the Parent Debt of Borrower owing to it to the Obligations. Unless otherwise
accepted or approved in writing by Lender, such Subordination Agreement shall be
substantially in the form of Exhibit "I".

     "Subsidiary" shall mean any corporation, partnership, business association
or other entity (including any Subsidiary of any of the foregoing) of which
Borrower owns, directly or indirectly through one or more Subsidiaries, fifty
percent (50%) or more of the capital stock or other Equity Interest having
ordinary power for the election of directors or others performing similar
functions.

     "Telephone Instruction Letter" shall mean a letter, dated the Closing Date,
issued by a duly authorized officer of Borrower, in substantially the form of
Exhibit "J".

     "Termination Date" shall mean the earliest to occur of the following dates:
(i) that date on which, pursuant hereto, Lender terminates the Line of Credit
(or the Line of Credit is deemed automatically terminated) subsequent to the
occurrence of an Event of Default; (ii) the last day of the Initial Term; or
(iii) such later date as to which Lender and Borrower may agree in writing from
time to time hereafter, but not later than sixty (60) days prior to any
scheduled Termination Date.

     "UCC" shall mean the Uniform Commercial Code of Georgia, as in effect from
time to time.

     1.2. Use of Defined Terms. All terms defined in this Agreement and the
Exhibits shall have the same defined meanings when used in any other Loan
Documents, unless the context shall require otherwise.

     1.3. Accounting Terms. All accounting terms not specifically defined herein
shall have the meanings generally attributed to such terms under GAAP.

     1.4. UCC Terms. Any terms defined in Articles 8 or 9 of the UCC, including
"accounts", "chattel paper", "instruments", "general intangibles", "payment
intangibles," "inventory," "equipment," "fixtures" and "securities" shall have
the same meanings given to such terms thereunder as and when used in the Loan
Documents.

     2.   THE FINANCING.

          2.1. Extensions of Credit

          2.1.1. Line of Credit. On the Closing Date, subject to fulfillment of
all conditions precedent set forth herein, Lender agrees to open the Line of
Credit in favor of Borrower so that, during the period from the Closing Date to,
but not including, the Termination Date, so long as there is not in existence
any Default Condition or Event of Default and the requested Borrowing, if made,
will not cause a Default Condition or Event of Default to exist, Borrower may
borrow and repay and reborrow Advances under the Line of Credit; subject,
however, to the requirement that at no time shall the aggregate principal amount
of outstanding Advances under the Line of Credit exceed the lesser of: (A) the
Maximum Amount or (B) the Borrowing Base (such requirements being generally
referred to herein as the "Borrowing Base Requirement"); and subject, further,
to the requirement that if, at any time hereafter, the Borrowing Base
Requirement is not satisfied, Borrower will immediately repay the then principal
balance of the Master Note by that amount necessary to satisfy the Borrowing
Base Requirement; provided, however, that, notwithstanding the foregoing, if
Borrower's failure to meet the Borrowing Base Requirement occurs at any one time
hereafter by the action of Lender, taken at such time, in reducing the amount of
"Eligible Accounts" pursuant to clause (xv) of the definition thereof or
reducing the amount of "Eligible Inventory" pursuant to clause (x) of the
definition thereof (or reducing both such amounts simultaneously), then,
Borrower shall have ten (10) days from the date such reduction(s) become
effective within which to cause compliance with the Borrowing Base Requirement.
All proceeds so obtained under the Line of Credit may be used by Borrower for
working capital in such manner as Borrower may elect in the ordinary course of
its business operations. The Debt arising from

                                       8
<PAGE>

Advances made to or on behalf of Borrower under the Line of Credit shall be
evidenced by the Master Note, which shall be executed by Borrower and delivered
to Lender on the Closing Date. The outstanding principal amount of the Master
Note may fluctuate from time to time, but shall be due and payable in full on
the Termination Date, and shall bear interest from the date of each disbursement
of principal until paid in full at the Applicable Rate, payable in the manner
described in Section 2.2.1. Borrower may request Advances under the Line of
Credit by giving to Lender a Notice of Borrowing not later than 11:00 a.m.
(Atlanta, Georgia time) on the date of the requested Advance; provided, however,
that, in accordance with the Telephone Instruction Letter, Borrower may provide
such instructions by telephone, provided that any such telephone request shall
be confirmed in writing, if requested by Lender, not later than the Business Day
following the disbursement of the requested Advance. The Line of Credit shall
terminate on the Termination Date, but may be terminated earlier by Borrower,
upon its giving at least ten (10) days advance written notice to Lender,
subject, however, to Borrower's payment of any early termination fee then due
(if so specified in Section 2.2.2).

          2.1.2. Letters of Credit. Borrower has proposed that the Line of
Credit be utilized from time to time, at Borrower's request, to support the
issuance of one or more letters of credit for the account of Borrower (each, a
"Letter of Credit," and, collectively, "Letters of Credit"), either by Lender's
making (or joining with Borrower in making) application to the issuer(s) of such
Letters of Credit (the "Issuers" or an "Issuer") therefor, or otherwise by
Lender's issuance of a risk participation or similar agreement in favor of the
Issuer(s) in regard thereto (the foregoing herein called, generally, a "Risk
Participation Arrangement"). Lender has agreed to such proposal, subject,
however, to the following terms, covenants and conditions:

               (a) Notice. Borrower shall give Lender at least five (5) Business
Days advance written notice of Borrower's request that Lender enter into a Risk
Participation Arrangement (a "Risk Participation Request") specifying the face
amount of the underlying Letter of Credit, its issuer, its expiry date, its
beneficiary and its purpose; e.g., whether "commercial" or "standby."

               (b) Acceptance of Risk Participation. Lender may accept or reject
any Risk Participation Request. Without limitation of the foregoing, no Risk
Participation Request will be accepted if: any Default Condition or Event of
Default then exists; the face amount of the Letter of Credit specified in the
Risk Participation Request, when added to all Advances then outstanding, would
cause the Margin Requirement to be exceeded; the expiry date of the Letter of
Credit specified in the Risk Participation Request exceeds the earlier of: (i)
one (1) year, or (ii) the Termination Date; the face amount of the Letter of
Credit specified in the Risk Participation Request, when aggregated with the
face amounts of all Letters of Credit for which Risk Participation Arrangements
are then outstanding, such dollar amount as Lender may establish or accept from
time to time as an absolute limit on Letters of Credit issued pursuant hereto;
the Issuer has not been selected by, or approved by, Lender; or Lender and the
Issuer are unable to reach agreement on the terms of the underlying Risk
Participation Arrangement.

               (c) Accepted Risk Participations. Once Lender has entered into
any Risk Participation Arrangement with respect to a Letter of Credit, then:
pending its expiry, the amount available for drawing under each Letter of Credit
shall be deemed an outstanding Advance for purposes of determining Borrower's
ongoing compliance with the Borrowing Base Requirement; i.e., the amount thereof
shall be charged against the Line of Credit; and if Lender remits any payment to
the Issuer in respect of such Letter of Credit, whether upon a drawing therefor,
in settlement thereof or otherwise, the full amount of such payment shall be
automatically charged as an Advance (whether or not an Event of Default then
exists or would be caused thereby); and Lender shall reimburse itself from the
proceeds thereof; or, if such Advance cannot be made; i.e., if the Line of
Credit already has terminated, then, Borrower shall, on demand from Lender,
reimburse Lender for the full amount of such payment (the foregoing herein
called Borrower's "Reimbursement Obligations").

               (d) Reimbursement Obligations. Borrower's Reimbursement
Obligations arising from time to time hereunder shall: be continuing, absolute
and unconditional; constitute part of the Obligations and be secured by all
Collateral; if not paid in full when due, either by the making of an Advance or
otherwise, bear interest until fully paid at the Default Rate; and survive
termination of the Line of Credit.

               (e) Cash Imposts. If any Default Condition or Event of Default
exists at any time while any such Risk Participation Arrangement is in effect,
Lender may require that cash equal in amount to 110%

                                       9
<PAGE>

of the undrawn amount of each underlying Letter of Credit be posted with Lender
by Borrower as additional Collateral for the payment of Borrower's Reimbursement
Obligations in regard thereto; or, if Lender is then or thereafter enforcing its
rights and remedies respecting Collateral, Lender may reserve from the proceeds
thereof such cash in order to assure that the Reimbursement Obligations then
outstanding shall be paid when due.

               (f) Indemnity. Borrower shall indemnify and save Lender and hold
Lender harmless from any loss, damage, cost or expense which Lender incurs in
entering into, or performing under, any Risk Participation Arrangement.

          2.1.3. Special Advance. On the Closing Date, subject to fulfillment of
all conditions precedent set forth herein, Lender shall make a one-time special
advance, equal in principal amount to Two Hundred Thousand Dollars ($200,000) to
Borrower (the "Special Advance"), the entire proceeds of which shall be
disbursed to Borrower on the Closing Date and be used to pay an early
termination fee or charge to the Existing Lender in connection with the
refinancing of the Debt due it on the Closing Date. The Special Advance shall be
repaid in thirty-six (36) installments of Five Thousand Five Hundred Fifty-Five
Dollars ($5,555) per month, beginning on December 1, 2001, and continuing on the
first day of each succeeding calendar month (except that the last such
installment shall be in that amount necessary to pay in full the Special
Advance), and shall be subject to earlier, mandatory prepayment, in full, upon
any acceleration of the maturities of the Obligations pursuant to Section 9.1.
The Special Advance shall bear interest until paid in full at an interest equal
to the Applicable Rate, due and payable monthly in arrears, beginning on
December 1, 2001, and continuing on the same day of each succeeding calendar
month (for the preceding calendar month). All payments of principal of and
accrued interest on the Special Advance shall be charged as Advances, as and
when the same become due and payable, whether or not the Borrowing Base
Requirement is violated as a result thereof, and Lender shall pay itself from
the proceeds of such Advance. The Debt represented by the Special Advance shall
not be evidenced by a promissory note, initially; but, at its option, Lender may
require hereafter that a promissory note be issued in regard thereto by Borrower
to evidence the Debt then represented thereby.

          2.2. Interest and Other Charges.

          2.2.1. Interest. Lender and Borrower agree that the interest rate
payable on the Borrowings shall be determined and paid as follows:

               (a) Line of Credit. Outstanding Advances under the Line of Credit
shall bear interest at the Applicable Rate.

               (b) Payment of Interest. Accrued interest on Borrowings shall be
due and payable monthly in arrears, on the first day of each calendar month, for
the preceding calendar month (or portion thereof), commencing on the first day
of the first calendar month following the Closing Date; and after maturity, on
demand.

               (c) Calculation of Interest and Fees. Interest on the Special
Advances, any Borrowings and any fees described in Section 2.2.2 computed on a
per annum basis shall be calculated on the basis of a 360-day year and actual
days elapsed. The Applicable Rate shall change with each change in the Prime
Rate, as determined by Lender, effective as of the opening of business on the
Business Day of such change.

               (d) Charging of Interest and Costs. Accrued and unpaid interest
on any Borrowings, any outstanding fees described in Section 2.2.2 and any
reimbursable costs and expenses specified in Section 10.6, may, when due and
payable, be paid, at Lender's option (without any obligation to do so), by
Lender's charging the Line of Credit for an Advance in the amount thereof; but
Borrower shall be and remain responsible for the payment of such sums to the
extent not so paid by Lender.

          2.2.2. Fees. In addition to the payment of interest at the Applicable
Rate and the charging of Letter of Credit pursuant to Section 2.1.2, Borrower
shall also be obligated to pay Lender all fees and charges specified below:

                                       10
<PAGE>

               (a) Loan Origination Fee. A loan origination fee, equal in amount
to Sixty Thousand Dollars ($60,000), which shall be fully earned as of, and due
and payable on, the Closing Date.

               (b) Non-Usage Fee. Monthly, on the first day of each calendar
month, commencing on the first of such dates following the Closing Date,
Borrower shall pay to Lender a fee equal to (x) 20/100ths of one percent (.20%)
per annum, times (y) the difference between (A) the Maximum Amount, and (B) the
aggregate amount of outstanding Advances, determined on a daily average basis
for the immediately preceding calendar month (or portion thereof, as the case
may be).

               (c) Early Termination Fee. If this Agreement is terminated prior
to the Termination Date, there shall be due and payable to Lender upon such
termination occurring, as liquidated damages for the loss of its bargain and not
as a penalty, a sum equal to the product of (i) the Maximum Amount, multiplied
by (ii) a percentage, equal to (A) two percent (2%), if the early termination
occurs on or before the first anniversary of the Closing Date, and (B) one
percent (1%), if the early termination occurs after the anniversary of the
Closing Date, but on or before the second anniversary of the Closing Date; and
(C) one-half of one percent (1/2%), if the early termination occurs after the
second anniversary of the Closing Date and prior to the third anniversary of the
Closing Date. Notwithstanding the foregoing, however, if an early termination
occurs as a result of an Event of Default in respect of Section 8.14, then, the
termination fee percentage shall be three percent (3%), regardless of date of
occurrence.

               (d) Audit Fees. With respect to field audits conducted by Lender
pursuant to Section 10.3, based on a ninety (90) day audit cycle (which may be
increased, in Lender's discretion, whenever an Event of Default exists),
Borrower shall reimburse Lender on demand the sum of $750.00 per day plus
out-of-pocket expenses.

               (e) Miscellaneous Fees. Borrower shall also reimburse Lender for
returned item fees and bank service charges levied by any financial institution
on Lender in connection with remittances made or received in furtherance hereof,
plus handling fees. Wire transfer fees incurred by Lender in such regards shall
also be reimbursed plus handling fees.

               (f) Letter of Credit Fees. In consideration of Lender's entry
into each Risk Participation Arrangement, Borrower shall pay to Lender during
the tenor thereof a fee equal to the product of the Applicable Margin times the
daily average amount available for drawing under each Letter of Credit,
determined and payable monthly in arrears on the first day of each calendar
month, for the preceding calendar month. This fee shall be in addition to any
fees or charges which Lender pays to the Issuer in respect of such Letter of
Credit, which also shall be reimbursed to Lender by Borrower, upon demand.

          2.2.3. Usury Savings Provisions. Lender and Borrower hereby further
agree that the only charge imposed by Lender upon Borrower for the use of money
in connection herewith is and shall be interest at the Applicable Rate, and that
all other charges imposed by Lender upon Borrower in connection herewith, are
and shall be deemed to be charges made to compensate Lender for underwriting and
administrative services and costs, and other services and costs performed and
incurred, and to be performed and incurred, by Lender in connection with making
credit available to Borrower hereunder, and shall under no circumstances be
deemed to be charges for the use of money. In no contingency or event whatsoever
shall the aggregate of all amounts deemed interest hereunder or under the Notes
and charged or collected pursuant to the terms of this Agreement or pursuant to
the Notes exceed the highest rate permissible under any law which a court of
competent jurisdiction shall, in a final determination, deem applicable hereto.
In the event that such a court determines that Lender has charged or received
interest hereunder in excess of the highest applicable rate, the rate in effect
hereunder shall automatically be reduced to the maximum rate permitted by
applicable law and Lender shall promptly refund to Borrower any interest
received by Lender in excess of the maximum lawful rate or, if so requested by
Borrower, shall apply such excess to the principal balance of the Obligations.
It is the intent hereof that Borrower not pay or contract to pay, and that
Lender not receive or contract to receive, directly or indirectly in any manner
whatsoever, interest in excess of that which may be paid by Borrower under
applicable law.

          2.3. General Provisions as to Payments.

                                       11
<PAGE>

          2.3.1. Method of Payment. Unless and except to the extent otherwise
approved in writing by Lender from time to time, payments of interest, fees and
principal pursuant to this Agreement must be received by Lender at an account
designated by Lender for such purpose no later than 11:00 a.m. (Atlanta, Georgia
time) on the date when due, in federal or other funds immediately available to
Lender in Atlanta, Georgia.

          2.3.2. Application of Payment. Except as otherwise expressly set forth
herein, all payments received by Lender hereunder shall be applied, in
accordance with the then current billing statement applicable to the Borrowing,
first to accrued interest, then to fees, and then to principal due. Any
remaining funds shall be applied to the further reduction of principal.
Notwithstanding the foregoing, upon the occurrence of a Default Condition or
Event of Default, payments shall be applied to the Obligations in such order as
Lender, in its sole discretion, may elect.

          2.3.3. Crediting of Payments. The receipt of any item of payment by
Lender shall be applied to reduce the Obligations, as provided in Section 2.3.2,
but, for purposes of computing interest charges hereunder, each such item of
payment shall be deemed paid and applied the number of Business Days after
actual receipt thereof specified as Collection Days in Section 1.1.

          2.3.4. Collections. Effective on the Closing Date, Borrower shall have
established, and thereafter Borrower shall maintain, with one or more banks
acceptable to Lender ("Clearing Banks"), lockbox accounts into which all
proceeds of Collateral, including, particularly, payments on Accounts Receivable
Collateral, shall be remitted ("Lockbox Accounts"). Lockbox Accounts may be in
Borrower's name, but if so, Borrower, Clearing Bank and Lender must have entered
into a tri-party agreement, to be substantially in the form of Exhibit "L"
unless otherwise required or approved by Lender (a "Blocked Account Agreement")
pursuant to which, among other things, said Clearing Bank shall agree to remit
all collected funds in its Lockbox Account directly to Lender for application to
the Obligations as prescribed below. All collected funds deposited into a
Lockbox Account shall be remitted on a daily basis directly to Lender for
application to Lender as provided in Section 2.3.2. The foregoing shall be in
addition to, and not in limitation of, Lender's rights to collect Accounts
Receivable Collateral directly pursuant after and Event of Default has occurred
and while it is continuing, as provided hereinbelow.

          3. SECURITY INTEREST.

          3.1. Grant of Security Interest. As security for the payment of all
Obligations, Borrower hereby grants to Lender a continuing, general lien upon
and security interest and security title in and to the following described
property, or interests in property, of Borrower, wherever located, whether now
existing or hereafter acquired or arising (herein collectively called the
"Collateral"), namely: (a) the Accounts Receivable Collateral; (b) the Inventory
Collateral; (c) the Equipment Collateral; (d) the Balances Collateral; (e) the
Intangibles Collateral; and (f) all products and/or proceeds of any and all of
the foregoing, including, without limitation, insurance proceeds.

          3.2. Representations, Warranties and Covenants Applicable to
Collateral. Borrower represents, warrants and covenants that:

          3.2.1. Good Title. Borrower has marketable title to the Collateral,
free and clear of all Liens, other than any Permitted Encumbrances.

          3.2.2. Right to Pledge. Borrower has full right, power and authority
to grant to Lender a security interest in the Collateral on the terms set forth
herein, and the grant of such security interest shall not result in Borrower
being in default of any other Debt or require Borrower to grant a Lien on any
Collateral to the holder of any such Debt.

          3.2.3. Sale of Collateral. Borrower will not sell, lease, exchange, or
otherwise dispose of any of the Collateral without the prior written consent of
Lender, except that: (i) Borrower may sell portions of its inventory in the
ordinary course of business for cash, or on open account or on other terms of
payment ordinarily extended to its customers (but any bulk sales thereof shall
be prohibited) and (ii) Borrower may sell, exchange or otherwise dispose of
portions of its equipment which are obsolete, worn-out or unsuitable for
continued use by Borrower if such equipment is replaced promptly upon its
disposition with equipment constituting equipment having a market value equal to
or greater than the equipment so disposed of and in which Lender shall obtain
and have a

                                       12
<PAGE>

first priority security interest pursuant hereto or, in any event grant a Lien
or permit a Lien to exist thereon, except for a Permitted Encumbrance. Upon the
sale, exchange or other disposition of any Collateral permitted to be sold
hereunder, the security interest and lien created and provided for herein,
without break in continuity and without further formality or act, shall continue
in and attach to any proceeds thereof, including, without limitation, accounts,
contract rights, shipping documents, documents of title, bills of lading,
warehouse receipts, dock warrants, dock receipts and cash or noncash proceeds,
and in the event of any unauthorized sale or other disposition, shall continue
in the Collateral itself.

          3.2.4. Insurance. Borrower will obtain and maintain insurance on that
portion of the Collateral consisting of tangible property with such companies,
in such amounts and against such risks as Lender may reasonably request, with
loss payable to Lender as its interests may appear. Such insurance shall not be
cancellable by Borrower, unless with the prior written consent of Lender, or by
Borrower's insurer, unless with at least thirty (30) days (or any lesser number
of days otherwise approved by Lender) advance written notice to Lender. In
addition, Borrower shall cause its insurer to provide Lender with at least
thirty (30) days advance written notice prior to insurer's nonrenewal of such
insurance. Borrower shall provide to Lender a copy of each such policy. All
proceeds received by Lender as loss payee of any such insurance shall be applied
to the Obligations, unless otherwise approved by Lender. Borrower shall file
with Lender on the Closing Date and annually thereafter a detailed list of such
insurance as then in effect, certified by Borrower's insurer, together with
copies of all policies of such insurance (if requested by Lender). Within thirty
(30) days after being requested by Lender to do so, Borrower will obtain such
additional insurance (or increase its existing coverage) as Lender may request
(but not more frequently than annually, unless an Event of Default then exists).

          3.2.5. Location. As of the Closing Date, the Collateral is situated
only at one or more of the Collateral Locations, and Borrower covenants with
Lender not to locate the Collateral at any location other than a Collateral
Location without giving at least thirty (30) days prior written notice to
Lender.

          3.2.6. Preservation. Hereafter, Borrower will take all commercially
reasonable measures to, maintain, protect and preserve the Collateral.

     4. GENERAL REPRESENTATIONS AND WARRANTIES. In order to induce Lender to
enter into this Agreement, Borrower hereby represents and warrants to Lender
(which representations and warranties, together with any other representations
and warranties of Borrower contained elsewhere in this Agreement, shall be
deemed to be renewed as of the date of each Advance), as set forth below:

          4.1. Existence and Qualification. Borrower is duly organized, validly
existing and in good standing under the laws of its Home State with its
principal place of business, chief executive office and office where it keeps
all of its books and records being located at the Executive Office, and Borrower
is duly qualified to do business in each other state in which a Collateral
Location is situated or wherein the conduct of its business or the ownership of
its property requires such qualification. Borrower has as its official name, as
registered with the secretary of state of its Home State, the words first
inscribed hereinabove as its name, and, except as may be described on the
Borrower Information Schedule, has not done business under any other name within
the five (5) years preceding the Closing Date.

          4.2. Authority; and Validity and Binding Effect. Borrower has the
power to make, deliver and perform under the Loan Documents, and to borrow
hereunder, and has taken all necessary and appropriate action to authorize the
execution, delivery and performance of the Loan Documents. This Agreement
constitutes, and the remainder of the Loan Documents, as and when executed and
delivered for value received, will constitute, the valid obligations of
Borrower, legally binding upon it and enforceable against it in accordance with
their respective terms.

          4.3. Incumbency and Authority of Signing Officers. Each undersigned
officer of Borrower holds the office specified hereinbelow and, in such
capacity, is duly authorized and empowered to execute, attest and deliver this
Agreement and the remainder of the Loan Documents for and on behalf of Borrower,
and to bind Borrower accordingly thereby.

                                       13
<PAGE>

          4.4. No Material Litigation. On the Closing Date, except as may be set
forth on the Borrower Information Schedule, there are no legal proceedings
pending (or, so far as Borrower knows, threatened), before any court or
administrative agency which, if adversely determined, could reasonably be
expected to result in a Material Adverse Change.

          4.5. Taxes. As of the Closing Date, Borrower has filed, or has
obtained extensions for the filing of, or caused to be filed all tax returns
required to be filed by it and has paid all taxes shown to be due and payable by
it on said returns or on any assessments made against it.

          4.6. Capital. All Equity Interests of Borrower issued and outstanding
on the Closing Date are validly and properly issued in accordance with all
applicable laws. The Parent own all of the issued and outstanding Equity
Interests of Borrower.

          4.7. Organization. The Organization Documents of Borrower are in full
force and effect under the laws of the state of its Home State, and all
amendments to the Organization Documents have been duly and properly made under
and in accordance with all applicable laws.

          4.8. No Insolvency. After giving effect to the execution and delivery
of the Loan Documents and the extension of any credit or other financial
accommodations hereunder, Borrower will not be Insolvent.

          4.9. No Violations. The execution, delivery and performance by
Borrower of this Agreement and the other Loan Documents have been duly
authorized by all necessary organizational action on the part of Borrower and do
not and will not require any consent or approval of the Parent or any other
Person which has not been obtained prior to the date hereof; or violate any
provision of any law, rule, regulation, order, writ, judgment, injunction,
decree, determination or award presently in effect having applicability to
Borrower or of any Organization Documents of Borrower; or, except with respect
to the Existing Lender Agreement, result in a breach of or constitute a default
under any indenture or loan or credit agreement or any other agreement, lease or
instrument to which Borrower is a party or by which it or its properties may be
bound or affected; and, except with respect to the Existing Lender Agreement,
Borrower is not in default under any such indenture, agreement, lease or
instrument or, to its knowledge, under any such law, rule, regulation, order,
writ, judgment, injunction, decree, determination or award.

          4.10. Financial Statements. The financial statements of Borrower and
its Consolidated Subsidiaries (if any) for its most recently completed Fiscal
Year and for that portion of its current Fiscal Year ended with that Fiscal
Month ended closest to the Closing Date for which financial statements have been
prepared, including balance sheet, income statement and, if available, statement
of changes in cash flow, copies of which heretofore have been furnished to
Lender, are complete and accurately and fairly represent the financial condition
of Borrower and its Consolidated Subsidiaries (if any), the results of its
operations and the transactions in its equity accounts as of the dates and for
the periods referred to therein, and have been prepared in accordance with GAAP.
There are no material liabilities, direct or indirect, fixed or contingent, of
Borrower or any such Consolidated Subsidiaries as of the date of such financial
statements which are not reflected therein or in the notes thereto. No Material
Adverse Change has occurred since the date of the balance sheet contained in the
annual audited financial statement of Borrower described hereinabove.

          4.11. Compliance with Laws. Borrower is in compliance with all
applicable laws, rules, regulations and orders of any governmental authority on
the Closing Date, excepting the noncompliance with which would or could
reasonably be expected to result in a Material Adverse Change. Borrower
possesses all franchises, certificates, licenses, permits and other
authorizations from governmental political subdivisions or regulatory
authorities, and all patents, trademarks, service marks, trade names,
copyrights, licenses and other, similar rights, free from burdensome
restrictions, that are necessary for the ownership, maintenance and operation of
any of its properties and assets; and Borrower is not in violation of any
thereof. A complete and accurate list of all such patents, trademarks, service
marks, trade names, copyrights, licenses and other, similar rights owned by
Borrower in existence on the Closing Date is set forth on the Borrower
Information Schedule attached hereto. Without limitation of the foregoing, (i)
Borrower, as a wholly-owned Subsidiary of Parent, has full and complete access
to, and right and authority to manufacture distribute products pursuant to, the
Immuno License, and (ii) Lender, as secured party, having been granted a
security interest by Borrower in the Immuno Licensed Products now or hereafter
owned by

                                       14
<PAGE>

Borrower pursuant hereto, shall have the right to sell Immuno Licensed Products
in furtherance of Section 9.3 hereof subsequent to an Event of Default occurring
and acceleration of the maturities of the Obligations as a result thereof
subject to compliance with any limitations on sale imposed under the FDA
Approval.

          4.12. Subsidiaries. As of the Closing Date, Borrower has no
Subsidiaries except as may be described on the Borrower Information Schedule.

          4.13. Federal Taxpayer Identification Number. Borrower's federal
taxpayer identification number is as indicated on the Borrower Information
Schedule.

     5. AFFIRMATIVE COVENANTS. Borrower covenants to Lender that from and after
the Closing Date, and so long as any amounts remain unpaid on account of any of
the Obligations or this Agreement remains effective (whichever is the last to
occur), Borrower will comply (and cause each Subsidiary to comply) with the
affirmative covenants set forth below:

          5.1. Records Respecting Collateral. All records of Borrower and each
Subsidiary with respect to the Collateral will be kept at its Executive Office
and will not be removed from such address without the prior written consent of
Lender.

          5.2. Further Assurances. Borrower shall duly execute and/or deliver
(or cause to be duly executed and/or delivered) to Lender any instrument,
invoice, document, document of title, dock warrant, dock receipt, warehouse
receipt, bill of lading, order, financing statement, assignment, waiver, consent
or other writing which may be reasonably necessary to Lender to carry out the
terms of this Agreement and any of the other Loan Documents and to perfect its
security interest in and facilitate the collection of the Collateral, the
proceeds thereof, and any other property at any time constituting security to
Lender, promptly after, but not later than ten (10) days after, Lender requests
that Borrower do so. Borrower shall perform or cause to be performed such acts
as Lender may request to establish and maintain for Lender a valid and perfected
security interest in and security title to the Collateral, free and clear of any
liens, encumbrances or security interests other than Permitted Encumbrances,
promptly after, but not later than ten (10) days after, Lender requests that
Borrower do so. Without limitation of the foregoing, in the case of any
Intangibles Collateral consisting of patents or trademarks, or applications
therefor, registered with the U.S. Patent and Trademark Offices ("USPTO") now or
hereafter owned by Borrower, Borrower shall give Lender notice thereof and
promptly thereafter, but not later than ten (10) days thereafter, execute and
deliver to Lender collateral assignments thereof in form and substance
sufficient for recordation at the USPTO (herein, "IP Assignments").

          5.3. Right to Inspect and Conduct Audits. Lender (or any Person or
Persons designated by it) shall have the continuing right to call at the
Executive Office or any Collateral Location at any time and, without hindrance
or delay, inspect, audit, check and make extracts from Borrower's or any
Subsidiary's books, records, journals, orders, receipts and any correspondence
and other data relating to the Collateral, to Borrower's or any Subsidiary's
business or to any other transactions between the parties hereto.

          5.4. Borrowing Base Certificates. On a weekly basis, as soon as
practicable after, but not later than the second Business Day after, the end of
each calendar week, or less frequently if approved by Lender from time to time,
Borrower shall prepare and deliver to Lender a Borrowing Base Certificate with
respect to satisfaction of the Borrowing Base Requirement as of the date of
report submission, the statements in which, in each instance, shall be certified
as to truth and accuracy by a duly authorized officer of Borrower.

          5.5. Collateral Status Certificates. Borrower shall, as soon as
practicable, but in any event on or before ten (10) days after the end of each
Fiscal Month, furnish or cause to be furnished to Lender a Collateral Status
Certificate, certified by a duly authorized officer of Borrower, showing (i) the
aggregate dollar value of the items comprising the Accounts Receivable
Collateral and the age of each individual item thereof as of the last day of the
preceding Fiscal Month (segregating such items in such manner and to such degree
as Lender may request), plus (ii) the type, dollar value and location of the
Inventory Collateral as at the end of the preceding Fiscal Month, valued at the
lower of its Booked Cost or market value, plus (iii) an accounts payable aging.
Additionally, Lender may, from time to time, verify the individual account
balances of any individual Account Debtors. Further, upon request from Lender,
made at any time hereafter, and, in any event, with the above-described
Collateral Status Certificate

                                       15
<PAGE>

for the month of December in each year, Borrower shall furnish Lender with a
then current Account Debtor name and address list.

          5.6. Periodic Financial Statements. Borrower shall, as soon as
practicable, and in any event within thirty (30) days after the end of each
Fiscal Month, furnish to Lender unaudited consolidating financial statements of
Parent and Borrower, including balance sheets, income statements and statements
of cash flow, for the Fiscal Month ended, and for the Fiscal Year to date. All
such financial statements shall be certified by a duly authorized officer of
Parent to present fairly the financial position and results of operations of
Parent and Borrower for the period involved in accordance with GAAP (but for the
omission of footnotes and subject to year-end audit adjustments).

          5.7. Annual Financial Statements Borrower shall, as soon as
practicable, and in any event within ninety (90) days after the end of each
Fiscal Year, furnish to Lender the annual audit report of Parent and its
Consolidated Subsidiaries, certified without material qualification by
independent certified public accountants selected by Parent, and prepared in
accordance with GAAP, together with relevant financial statements of Parent and
its Consolidated Subsidiaries for the Fiscal Year then ended, on a consolidated
and an unaudited consolidating basis. Borrower shall cause said accountants to
furnish Lender with a statement that in making their examination of such
financial statements, they obtained no knowledge of any Event of Default or
Default Condition which pertains to accounting matters relating to this
Agreement or the Notes, or, in lieu thereof, a statement specifying the nature
and period of existence of any such Event of Default or Default Condition
disclosed by their examination.

          5.8. Compliance Certificate. Borrower shall, on a monthly basis not
later than thirty (30) days after the close of each of its first eleven Fiscal
Months and not later than ninety (90) days after the close of its Fiscal Year,
certify to Lender, in a Compliance Certificate, that no Event of Default and no
Default Condition exists or has occurred, or, if an Event of Default or Default
Condition exists, specifying the nature and period of existence thereof. Each
such Compliance Certificate shall include a computation showing compliance with
all financial covenants set forth in Article 7.

          5.9. Payment of Taxes. Borrower shall pay and discharge all taxes,
assessments and governmental charges upon it, its income and its properties
prior to the date on which penalties attach thereto, unless and to the extent
only that (i) such taxes, assessments and governmental charges are being
contested in good faith and by appropriate proceedings by Borrower, (ii)
Borrower maintains reasonable reserves on its books therefor and (iii) the
payment of such taxes does not result in a Lien upon any of the Collateral other
than a Permitted Encumbrance.

          5.10. Change of Principal Place of Business, Etc. Borrower hereby
understands and agrees that if, at time hereafter, Borrower or any Subsidiary
elects to move its Executive Office, or if Borrower or any Subsidiary elects to
change its name, identity or its organization structure, Borrower will notify
Lender in writing at least thirty (30) days prior thereto and, at Lender's
request, comply (or cause its Subsidiary to comply) with Section 5.2 hereof to
the extent Lender determines that any new or additional actions need to be
undertaken in regard thereto.

          5.11. Waivers. With respect to each of the Collateral Locations,
Borrower will use its reasonable best efforts to obtain Landlord Agreement, to
insure the priority of its security interest in that portion of the Collateral
situated at such locations. Should Borrower be unable to obtain any such
Landlord Agreements, Borrower understands that Lender may impose rent reserves
on the Borrowing Base for each affected Collateral Location.

          5.12. Preservation of Existence. Borrower shall preserve and maintain
(and cause its Subsidiaries to preserve and maintain) its organizational
existence, rights, franchises and privileges in its Home State, and qualify and
remain qualified to do business in each jurisdiction in which such qualification
is necessary or desirable in view of its business and operations or the
ownership of its properties.

          5.13. Compliance With Laws, Etc.. Borrower and each of its
Subsidiaries shall comply with the requirements of all applicable laws, rules,
regulations and orders of any governmental authority, noncompliance with which
would or could reasonably be expected to result in a Material Adverse Change.
Without limiting the

                                       16
<PAGE>

foregoing, each of Borrower and its Subsidiaries shall obtain and maintain all
permits, licenses and other authorizations which are required under, and
otherwise comply with, all federal, state, and local laws and regulations.

          5.14. Certain Required Notices. Promptly, upon its receipt of notice
or knowledge thereof, but not later than ten (10) days thereafter, Borrower will
report to Lender: (i) any lawsuit or administrative proceeding in which Borrower
or any Subsidiary is a defendant which, if decided adversely to Borrower or such
Subsidiary, could reasonably be expected to result in a Material Adverse Change;
or (ii) the existence and nature of any Default Condition or Event of Default;

          5.15. Immuno License. Borrower shall do (and cause Parent to do) all
rights necessary or advisable to keep and maintain the Immuno License in full
force and effect at all times hereafter in substantially the same form and
substance as in effect on the Closing Date.

          5.16. Logistics Contract. Borrower shall do all things necessary or
advisable to keep and maintain the Logistics Contract in full force and effect
at all times hereafter in substantially the same force and substance as in
effect on the Closing Date.

     6. NEGATIVE COVENANTS. Borrower covenants to Lender that from and after the
Closing Date, and so long as any amount remains unpaid on account of any of the
Obligations or this Agreement remains effective (whichever is the last to
occur), Borrower will not do (and will not permit any Subsidiary to do), any of
the things or acts set forth below, except with the prior written consent of
Lender:

          6.1. Encumbrances. Create, assume, or suffer to exist any Lien, except
for Permitted Encumbrances.

          6.2. Debt. Incur, assume, or suffer to exist any Debt, except for: (i)
Debt to Lender or any Affiliate of Lender; (ii) trade payables and contractual
obligations to suppliers and customers incurred in the ordinary course of
business; (iii) accrued pension fund and other employee benefit plan obligations
and liabilities (provided, however, that such Debt does not result in the
existence of any Event of Default or Default Condition under any other provision
of this Agreement); (iv) deferred taxes; (v) Debt resulting from endorsements of
negotiable instruments received in the ordinary course of its business; (vi)
Purchase Money Debt; (vii) the Parent Debt; (viii) Debt to the Existing Lender
under the Existing Lender Agreement being refinanced on the Closing Date; and
(ix) other Debt, not described in clauses (i) through (vi) above, existing on
the Closing Date, and disclosed in writing to Lender on the Borrower Information
Schedule.

          6.3. Contingent Liabilities. Guarantee, endorse, become surety with
respect to or otherwise become directly or contingently liable for or in
connection with the obligations of any other person, firm, or corporation,
except for endorsements of negotiable instruments for collection in the ordinary
course of business.

          6.4. Dividends. Declare or pay any dividends on, or make any
distribution with respect to, its Equity Interests; except as set forth in
Section 7.4.

          6.5. Redemption. Purchase, redeem, or otherwise acquire for value of
its Equity Interests.

          6.6. Investments. Make any investment in cash or by delivery of
property to any Person, whether by acquisition of Equity Interests or Debt, or
by loan, advance or capital contribution, or otherwise, in any Person or
property of a Person (herein called, subject to the following exceptions,
"Restricted Investments"), except for: (i) assets acquired from time to time in
the ordinary course of business; (ii) current assets arising from the sale of
goods or the provision of services in the ordinary course of business; (iii)
loans or advances made to employees of Borrower for salary, commissions, travel
or the like, made in the ordinary course of business not to exceed, in aggregate
amount, the Materiality Threshold; (iv) other investments not to exceed, in
aggregate amount, the Materiality Threshold; and (v) as set forth in Section
7.4.

                                       17
<PAGE>

          6.7. Mergers. Dissolve or otherwise terminate its organizational
status; or enter into any merger, reorganization or consolidation; or make any
substantial change in the basic type of business conducted by Borrower and its
Subsidiaries, as of the Closing Date.

          6.8. Business Locations. Transfer Executive Office, or open new
Collateral Locations, except upon at least thirty (30) days prior written notice
to Lender and after the delivery to Lender of financing statements, if required
by Lender, in form satisfactory to Lender, to perfect or continue the perfection
of Lender's Lien thereon.

          6.9. Affiliate Transactions. Enter into, or be a party to, or permit
any Subsidiary to enter into or be a party to, any transaction with any
Affiliate, except in the ordinary course of and pursuant to the reasonable
requirements of Borrower's or such Subsidiary's business and upon fair and
reasonable terms which are fully disclosed to Lender and are no less favorable
to Borrower than would be expected to be obtained in a comparable arm's length
transaction with a Person not an Affiliate. Without limiting the generality of
the foregoing, Borrower shall not enter into any "transfer pricing" or similar
arrangements with any Affiliate, except that Parent and Borrower may enter into
"transfer pricing" arrangements, subject to the limitation set forth in Section
7.4.

          6.10. Subsidiaries. Create any Subsidiary or divest itself of any
assets exceeding the Materiality Threshold by transferring them to any
Subsidiary which exists on the Closing Date or is hereafter created with
Lender's consent.

          6.11. Fiscal Year. Change its Fiscal Year, or permit any Subsidiary to
have a fiscal year different from the Fiscal Year of Borrower.

          6.12. Disposition of Assets. Sell, lease or otherwise dispose of any
of the Collateral, including any disposition of property as part of a sale and
leaseback transaction, to or in favor of any Person, except as otherwise
expressly permitted, as to certain Collateral, in Article 3.

          6.13. Federal Taxpayer Identification Number. Change or permit any
Subsidiary to change its federal taxpayer identification number without prior
written notice to Lender.

          6.14. Subordinated Debt. Pay any Subordinated Debt except to the
extent expressly provided in the Subordination Agreement or as Lender otherwise
may consent from time to time.

          6.15. Restrictions or Subsidiaries Enter into or assume any agreement
(other than the Loan Documents) prohibiting or otherwise restricting (i) the
creation or assumption of any Lien upon its or any Subsidiaries' properties, or
(ii) the ability of any Subsidiary to pay dividends or make other distributions
or transfers to Borrower.

          6.16. Different Business. Engage in any business other than a business
relating to biotechnology.

          6.17. Commingled Funds. Commingle any cash funds of Borrower and its
Subsidiaries with any cash funds of the Principal or any Shareholders

     7. FINANCIAL COVENANTS. Borrower covenants to Lender that, from and after
the Closing Date and so long as any amount remains on account of any of the
Obligations or this Agreement remains effective (whichever is the last to
occur), it will comply with the financial covenants set forth below.

          7.1. Minimum Tangible Net Worth. Borrower shall cause Parent to
maintain a minimum Tangible Net Worth of at least CDN $7,500,000 at all times.
As used herein, "Tangible Net Worth" shall mean Parent's book net worth,
determined on a consolidated basis for Parent and its Consolidated Subsidiaries,
including, specifically, Borrower, in accordance with GAAP, with inventory
calculated on a FIFO basis, but minus all assets of Parent and such Subsidiaries
constituting (i) goodwill, patents, copyrights, trademarks, trade names and
other intangible assets, other than intangible assets relating to the Immuno
License (ii) write-ups of assets, (iii)

                                       18
<PAGE>

unamortized debt discount and expense, and (iv) deferred charges, plus any other
Debts owing to such Person from any shareholders, officers or directors of such
Person, or from any Affiliates or Subsidiaries of such Person. For purposes
hereof, any minority interest in any Subsidiary shown on Parent's balance sheet
shall be excluded from its net worth and be included in its total liabilities.

          7.2. Capital Expenditures. Borrower shall not make Capital
Expenditures which exceed, in any Fiscal year, Two Hundred Fifty Thousand
Dollars ($250,000). As used herein, "Capital Expenditures" shall mean all
expenditures made in respect of the cost of any fixed asset or improvement, or
replacement, substitution, or addition thereto, having a useful life of more
than one (1) year, including, without limitation, those arising in connection
with the direct or indirect acquisition of such assets by way of increased
product or service charges or offset items or in connection with Capital Leases.
"Capital Leases" shall mean any leases of Property than, in accordance with
GAAP, should be reflected as liabilities on the balance sheet of Borrower.

          7.3. EBITDA. Borrower shall not permit the "EBITDA" (as hereafter
defined), measured for Parent and its Consolidated Subsidiaries in Dollars on a
trailing four (4) Fiscal Quarters' basis (except that, (i) for the Fiscal
Quarter ending April 30, 2002, "EBITDA" shall be measured on a trailing two (2)
Fiscal Quarters' basis, and (ii) for the Fiscal Quarter ending July 31, 2002,
"EBITDA" shall be measured on a trailing three (3) Fiscal Quarters' basis,
beginning with the Fiscal Quarter of Parent ending April 30, 2002, and
continuing on a quarterly basis thereafter, to be less than (or, if a negative
(-) number is denoted below, to exceed) the dollar amounts prescribed below
opposite the corresponding Fiscal Quarter end date:

               Fiscal Quarter Ending                    EBITDA
               ---------------------                    ------
                 4/30/02                            - $1,411,000
                 7/31/02                            - $2,332,000
                 10/31/02                           - $3,167,000
                 1/31/03                            - $3,058,000
                 4/30/03                            - $2,863,000
                 7/31/03                            - $1,841,000
                 10/31/03 and thereafter              - $691,000

     As used herein, "EBITDA" for Parent and its Consolidated Subsidiaries shall
mean the Dollar equivalent of Canadian dollars (using currency exchange rates
published in The Wall Street Journal as of each Fiscal Quarter end, or the next
closest day on which such newspaper is published), of the net income of the
Parent and its Consolidated Subsidiaries, determined in accordance with GAAP, on
a consolidated basis (but determined without regard to any extraordinary items
of gain or loss) plus, to the extent deducted from revenues in determining net
income for such period, all interest expenses, taxes, depreciation and
amortization expense of the Parent and its Consolidated Subsidiaries.

          7.4. Upstreaming of Cash and Property. Borrower shall not, whether by
dividend or distribution, loan, advance, capital contribution or other
investment, "transfer pricing" or otherwise, make any payments to Parent, or at
Parent's direction to any third Person on behalf of Parent, whether in cash or
in other property of Borrower, including, without limitation, any in respect of
the payment of interest or principal on any Subordinated Debt (the foregoing
herein called "Upstream Payments"), except with the prior written consent of
Lender; provided, however, that, notwithstanding the foregoing, during that
period beginning with the Closing Date and ending on that date which is one
hundred eighty (180) days after the Closing Date (the "Upstream End Date"),
Borrower may make Upstream Payments to Parent, subject, however, to the
following conditions precedent:

               (i) no Event of Default or Default Condition shall exist at the
     time any such Upstream Payment is made;

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<PAGE>

               (ii) "Excess Borrowing Availability" (defined as the amount (if
     any) by which (A) the lesser of (1) the Maximum Amount or (2) the Borrowing
     Base as then most recently reported to Lender exceeds (B) total outstanding
     Advances), both before and after the making of any such Upstream Payment,
     shall be at least One Hundred Thousand Dollars ($100,000);

               (iii) such Upstream Payments shall be made only for the purpose
     of reimbursing Parent for its actual operating expenses, not in excess of
     budgeted operating expenses, derived from a budget submitted to Lender
     before any such Upstream Payments are made;

               (iv) the aggregate amount of all such Upstream Payments (which,
     to the extent made in property, shall be computed at their fair market
     value at the time), made to Parent during the aforesaid period shall not
     exceed One Million Dollars ($1,000,000);

               (v) at the time any such Upstream Payment is made, but in any
     event not later than three (3) Business Days after the making of any such
     Upstream Payment, Borrower shall have submitted to Lender a certificate,
     executed by its chief financial officer, certifying the amount of such
     Upstream Payment made and Borrower's compliance with clauses (i) through
     (iv) above in regarding thereto; and

               (vi) subsequent to the Upstream End Date, no such Upstream
     Payments may be made by Borrower or received by Parent or any third Person
     at Parent's direction on behalf of Parent.

and, provided further, that, notwithstanding any term of this Section 7.4 to the
contrary, the term "Upstream Payment" as used herein shall not include any
payments made to third Person vendors by Borrower, on behalf of Parent, for
goods actually delivered to Borrower or for services actually rendered to
Borrower in respect of which Parent is (or was) the recipient of an invoice
therefor by such vendors, instead of Borrower. In such cases, Parent may tender
such invoices to Borrower, and Borrower may remit payment thereon directly to
the vendor(s) named thereon, if and to the extent that Borrower has received the
goods or services to which such invoices, in fact, relate, and Borrower's
remittances shall not constitute an "Upstream Payment" hereunder.

     8. EVENTS OF DEFAULT. The occurrence of any events or conditions set forth
below shall constitute an Event of Default hereunder, provided that any
requirement for the giving of notice or the lapse of time, or both, has been
satisfied:

          8.1. Obligations. Borrower shall fail to make any payment on any of
its Obligations, when due, and such Default Condition shall continue unremedied
for five (5) Business Days after receipt of notice thereof from lender.

          8.2. Misrepresentations. Any representations or warranties made herein
or in any of the Loan Documents or in any Guaranty or in any certificate or
statement furnished at any time hereunder or in connection with any of the Loan
Documents or any Guaranty shall prove to have been untrue or misleading in any
material respect when made or furnished.

          8.3. Certain Covenants. Borrower shall default in the observance or
performance of any covenant or agreement contained in (i) Article 5, excepting
Sections 5.9, 5.11, 5.13, 5.15 and 5.16 (which Sections shall be governed by
Section 8.4); (ii) Article 6, or (iii) Article 7.

          8.4. Other Covenants. Borrower, any Subsidiary or any Guarantor shall
default in the observance or performance of any covenant or agreement contained
herein, in any of the other Loan Documents or any Guaranty (other than default
the performance or observance of which is dealt with specifically elsewhere in
this Article 8) unless (i) with respect to this Agreement, such default is cured
to Lender's satisfaction within ten (10) days after the sooner to occur of
receipt of notice of such default from Lender or the date on which such default
first becomes known to Borrower and (ii) with respect to any other Loan Document
or Guaranty, such default is cured within any applicable grace, cure or notice
and cure period contained therein or ten (10) days, whichever is the later.

          8.5. Other Debts. Borrower, any Subsidiary or any Guarantor shall
default in connection with any agreement for Debt exceeding the Materiality
Threshold with any creditor, including Lender, which

                                       20
<PAGE>

automatically causes an acceleration in the maturity thereof or which entitles
said creditor to accelerate the maturity thereof, and such creditor actually
causes such acceleration of maturity to occur.

          8.6. Voluntary Bankruptcy. Borrower, any Subsidiary or any Guarantor
shall file a voluntary petition in bankruptcy or a voluntary petition or answer
seeking liquidation, reorganization, arrangement, readjustment of its debts, or
for any other relief under the Bankruptcy Code, or under any other act or law
pertaining to insolvency or debtor relief, whether state, Federal, or foreign,
now or hereafter existing; Borrower, any Subsidiary or any Guarantor shall enter
into any agreement indicating its consent to, approval of, or acquiescence in,
any such petition or proceeding; Borrower, any Subsidiary or any Guarantor shall
apply for or permit the appointment by consent or acquiescence of a receiver,
custodian or trustee of Borrower, any Subsidiary or any Guarantor for all or a
substantial part of its property; Borrower, any Subsidiary or any Guarantor
shall make an assignment for the benefit of creditors; or Borrower, any
Subsidiary or any Guarantor shall be or become Insolvent; or Borrower, any
Subsidiary or any Guarantor shall admit, in writing, its inability or failure to
pay its debts generally as such debts become due.

          8.7. Involuntary Bankruptcy. There shall have been filed against
Borrower, any Subsidiary or any Guarantor an involuntary petition in bankruptcy
or seeking liquidation, reorganization, arrangement, readjustment of its debts
or for any other relief under the Bankruptcy Code, or under any other act or law
pertaining to insolvency or debtor relief, whether state, federal or foreign,
now or hereafter existing; Borrower, any Subsidiary or any Guarantor shall
suffer or permit the involuntary appointment of a receiver, custodian or trustee
of Borrower, any Subsidiary or any Guarantor or for all or a substantial part of
its property; or Borrower, any Subsidiary or any Guarantor shall suffer or
permit the issuance of a warrant of attachment, execution or similar process
against all or any substantial part of the property of Borrower, any Subsidiary
or any Guarantor; or any motion, complaint or other pleading is filed in any
bankruptcy case of any person or entity other than Borrower and such motion,
complaint or pleading seeks the consolidation of Borrower's assets and
liabilities with the assets and liabilities of such person or entity.

          8.8. Damage, Loss, Theft or Destruction of Collateral. There shall
have occurred material uninsured damage to, or loss, theft or destruction of,
any Collateral having a value, based on the lower of its depreciated cost or
market value, exceeding the Materiality Threshold.

          8.9. Judgments. A final judgment or order for the payment of money is
rendered against Borrower, any Subsidiary or any Guarantor in an amount
exceeding the Materiality Threshold (exclusive of amounts covered by insurance)
and either (x) enforcement proceedings shall have been commenced by any creditor
upon such judgment or order, or (y) a stay of enforcement of such judgment or
order, by reason of a pending appeal or otherwise, shall not be in effect for
any period of thirty (30) consecutive days.

          8.10. Disavowal of Certain Obligations. Any Person (other than Lender)
party to a Guaranty or Subordination Agreement shall disavow its obligations
thereunder; or any such Guaranty or Subordination Agreement is alleged to be, or
determined by any governmental authority to be, invalid, unenforceable or
otherwise not binding on any Person party thereto (other than Lender), in whole
or in part.

          8.11. Material Adverse Change. There shall occur any Material Adverse
Change.

          8.12. Change of Control, Etc. Either: (i) the Parent shall cease to
Control Borrower or (ii) any Person or Persons not in Control of Parent on the
Closing Date shall obtain Control of the Parent.

          8.13. Change in Management, Etc. Either: (i) Marc Paquin shall die,
become incapacitated, cease to be a chief executive officer of Borrower or
otherwise cease to be actively involved in the day-to-day executive management
of Borrower, unless (A) Borrower employs or engages another individual with
knowledge or experience reasonably sufficient to serve as interim chief
executive officer of a corporation of similar size and type as Borrower within
ten (10) days thereafter, and (B) Borrower employs or engages another individual
with knowledge or experience reasonably sufficient to serve as chief executive
officer of a corporation of similar size and type as Borrower within one hundred
eighty (180) days thereafter; or (ii) Borrower shall fail to maintain generally
executive management satisfactory to Lender having sufficient skill and
experience in Borrower's industry to manage Borrower competently and
efficiently.

                                       21
<PAGE>

          8.14. Immuno License/Licensed Products. If, for any reason, the Immuno
License shall cease to be made available for use by Borrower on substantially
the same terms as in use by Borrower on the Closing Date; or, in any event,
either Borrower's or Lender's ability to sell or otherwise dispose of any
Inventory Collateral consisting of Immuno Licensed Products shall be denied or
materially impaired.

          8.15. Logistics Contract. If the Logistics Contract is terminated by
Borrower other than in accordance with Section 1.3 of the Logistics Contract, or
if Logistics terminates the Logistics Contract in accordance with Section 1.3 of
the Logistics Contract.

     9. REMEDIES. Upon the occurrence or existence of any Event of Default, or
at any time thereafter, without prejudice to the rights of Lender to enforce its
claims against Borrower for damages for failure by Borrower to fulfill any of
its obligations hereunder, subject only to prior receipt by Lender of payment in
full of all Obligations then outstanding in a form acceptable to Lender, Lender
shall have all of the rights and remedies set forth below, and it may exercise
any one, more, or all of such remedies, in its sole discretion, without thereby
waiving any of the others; provided, however, that, in addition to the
foregoing, if the Event of Default is in respect of Section 8.6 or 8.7, then,
automatically, immediately upon such Event of Default occurring, without
necessity of any further action on Lender's part, all commitments of Lender
hereunder and under all other Loan Documents shall terminate, and all
Obligations shall be immediately due and payable.

          9.1. Acceleration of the Obligations. Lender, at its option, may
terminate all commitments of Lender hereunder and under all other Loan
Documents, and declare all of the Obligations to be immediately due and payable,
whereupon the same shall become immediately due and payable without presentment,
demand, protest, notice of nonpayment or any other notice required by law
relative thereto, all of which are hereby expressly waived by Borrower, anything
contained herein to the contrary notwithstanding. If any note of Borrower to
Lender constituting Obligations, including, without limitation, any of the
Notes, shall be a demand instrument, however, the recitation of the right of
Lender to declare any and all Obligations to be immediately due and payable,
whether such recitation is contained in such note or in this Agreement, as well
as the recitation of the above events permitting Lender to declare all
Obligations due and payable, shall not constitute an election by Lender to waive
its right to demand payment under a demand at any time and in any event, as
Lender in its discretion may deem appropriate. Thereafter, Lender, at its
option, may, but shall not be obligated to, accept less than the entire amount
of Obligations due, if tendered, provided, however, that unless then agreed to
in writing by Lender, no such acceptance shall or shall be deemed to constitute
a waiver of any Event of Default or a reinstatement of any commitments of Lender
hereunder or under all other Loan Documents.

          9.2. Default. If Lender so elects, by further written notice to
Borrower, Lender may increase the rate of interest charged on the Notes then
outstanding for so long thereafter as the Event of Default giving rise thereto
continues to exist as Lender further shall elect by an amount not to exceed the
Default Rate.

          9.3. Remedies of a Secured Party. Lender shall thereupon have the
rights and remedies of a secured party under the UCC in effect on the date
thereof (regardless whether the same has been enacted in the jurisdiction where
the rights or remedies are asserted), including, without limitation, the right
to take possession of any of the Collateral or the proceeds thereof, to sell or
otherwise dispose of the same, to apply the proceeds therefrom to any of the
Obligations in such order as Lender, in its sole discretion, may elect. Lender
shall give Borrower written notice of the time and place of any public sale of
the Collateral or the time after which any other intended disposition thereof is
to be made. The requirement of sending reasonable notice shall be met if such
notice is given to Borrower at least ten (10) days before such disposition.
Expenses of retaking, holding, insuring, preserving, protecting, preparing for
sale or selling or the like with respect to the Collateral shall include, in any
event, reasonable attorneys' fees and other legally recoverable collection
expenses, all of which shall constitute Obligations.

          9.4. Repossession of the Collateral. Lender may take the Collateral or
any portion thereof into its possession, by such means (without breach of the
peace) and through agents or otherwise as it may elect (and, in connection
therewith, demand that Borrower assemble the Collateral at a place or places and
in such manner as Lender shall prescribe), and sell, lease or otherwise dispose
of the Collateral or any portion thereof in its then

                                       22
<PAGE>

condition or following any commercially reasonable preparation or processing,
which disposition may be by public or private proceedings, by one or more
contracts, as a unit or in parcels, at any time and place and on any terms, so
long as the same are commercially reasonable and Borrower hereby waives all
rights which Borrower has or may have under applicable law to notice and to a
judicial hearing prior to seizure of any Collateral by Lender.

          9.5. Direct Notification. Lender may, additionally, in its sole
discretion, at any time that an Event of Default exists, direct Account Debtors
to make payments on the Accounts Receivable Collateral, or portions thereof,
directly to Lender, and the Account Debtors are hereby authorized and directed
to do so by Borrower upon Lender's direction, and the funds so received shall be
also deposited in the Collateral Reserve Account, or, at the election of Lender,
upon its receipt thereof, be applied directly to repayment of the Obligations in
such order as Lender, in its sole discretion, shall determine.

          9.6. Other Remedies. Unless and except to the extent expressly
provided for to the contrary herein, the rights of Lender specified herein shall
be in addition to, and not in limitation of, Lender's rights under the UCC, as
amended from time to time, or any other statute or rule of law or equity, or
under any other provision of any of the Loan Documents, or under the provisions
of any other document, instrument or other writing executed by Borrower or any
third party in favor of Lender, all of which may be exercised successively or
concurrently.

     10.  MISCELLANEOUS

          10.1. Waiver. Each and every right granted to Lender under this
Agreement, or any of the other Loan Documents, or any other document delivered
hereunder or in connection herewith or allowed it by law or in equity, shall be
cumulative and may be exercised from time to time. No failure on the part of
Lender to exercise, and no delay in exercising, any right shall operate as a
waiver thereof, nor shall any single or partial exercise by Lender of any right
preclude any other or future exercise thereof or the exercise of any other
right. No waiver by Lender of any Default Condition or Event of Default shall
constitute a waiver of any subsequent Default Condition or Event of Default.

          10.2. GOVERNING LAW. THIS AGREEMENT AND THE OTHER LOAN DOCUMENTS, AND
THE RIGHTS AND OBLIGATIONS OF THE PARTIES HEREUNDER AND THEREUNDER, SHALL BE
GOVERNED BY, AND CONSTRUED AND INTERPRETED IN ACCORDANCE WITH, THE LAWS OF THE
STATE OF GEORGIA.

          10.3. Survival. All representations, warranties and covenants made
herein and in the Loan Documents shall survive the execution and delivery hereof
and thereof. The terms and provisions of this Agreement shall continue in full
force and effect, notwithstanding the payment of one or more of the Notes or the
termination of the Line of Credit, until all of the Obligations have been paid
in full and Lender has terminated this Agreement in writing.

          10.4. Assignments. No assignment hereof or of any Loan Document shall
be made by Borrower without the prior written consent of Lender. Lender may
assign, or sell participations in, its right, title and interest herein and in
the Loan Documents at any time hereafter without notice to or consent of
Borrower.

          10.5. Counterparts. This Agreement may be executed in two or more
counterparts, each of which when fully executed shall be an original, and all of
said counterparts taken together shall be deemed to constitute one and the same
agreement.

          10.6. Reimbursement. Borrower shall pay to Lender on demand all
reasonable out-of-pocket costs and expenses that Lender pays or actually incurs
in connection with the negotiation, preparation, consummation, amendment,
modification, enforcement and termination of this Agreement and the other Loan
Documents, including, without limitation: (a) fees and disbursements of legal
counsel; (b) costs and expenses of lien and title searches insurance; (c) actual
taxes, fees and other charges for recording any mortgages, filing any financing
statements and continuations, and other actions to perfect, protect and continue
the Lien of Lender in the Collateral; (d) sums paid or incurred to pay for any
amount or to take any action required of Borrower under the Loan Documents that
Borrower fails to pay or take; (e) costs of appraisals, inspections, field
audits and verifications of the Collateral, including, without limitation, costs
of travel, for inspections of the Collateral and Borrower's

                                       23
<PAGE>

operations by Lender (subject, however, to the limitations set forth in Section
2.2.2(d)); (f) costs and expenses of preserving and protecting the Collateral;
and (g) after an Event of Default, costs and expenses (including fees and
disbursements of legal counsel) paid or incurred to obtain payment of the
Obligations, enforce the Lender's Lien in any Collateral, sell or otherwise
realize upon the Collateral, and otherwise enforce the provisions of the Loan
Documents or to defend any claim made or threatened against Lender arising out
of the transactions contemplated hereby (including, without limitation,
preparations for and consultations concerning any such matters). Notwithstanding
the foregoing, Borrower shall not be required to reimburse or pay Lender for any
costs, fees and expenses incurred by Lender (including attorneys' fees) relating
to the examination, review, documentation, syndication or closing of the
transactions contemplated hereby, to the extent that the foregoing exceed
$35,000 in the aggregate. The foregoing shall not be construed to limit any
other provisions of the Loan Documents regarding costs and expenses to be paid
to Borrower. All of the foregoing costs and expenses may, in the discretion of
Lender, be charged as Advances. Borrower will pay all expenses incurred by it in
the transaction. In the event Borrower becomes a debtor under the Bankruptcy
Code, Lender's secured claim in such case shall include interest on the
Obligations and all fees, costs and charges provided for herein (including,
without limitation, reasonable attorneys' fees actually incurred) all for the
extent allowed by the Bankruptcy Code.

          10.7. Successors and Assigns. This Agreement and Loan Documents shall
be binding upon and inure to the benefit of the successors and permitted assigns
of the parties hereto and thereto.

          10.8. Severability. If any provision this Agreement or of any of the
Loan Documents or the application thereof to any party thereto or circumstances
shall be invalid or unenforceable to any extent, the remainder of such Loan
Documents and the application of such provisions to any other party thereto or
circumstance shall not be affected thereby and shall be enforced to the greatest
extent permitted by law.

          10.9. Notices. All notices, requests and demands to or upon the
respective parties hereto shall be deemed to have been given or made when
personally delivered or deposited in the mail, registered or certified mail,
postage prepaid, addressed as follows: (i) for Lender, care of the address of
Lender inscribed beneath its signature hereinbelow and (ii) for Borrower, care
of the address set forth as its Executive Office on the Borrower Information
Schedule (or to such other address as may be designated hereafter in writing by
the respective parties hereto) except in cases where it is expressly provided
herein or by applicable law that such notice, demand or request is not effective
until received by the party to whom it is addressed.

          10.10. Entire Agreement: Amendments. This Agreement, together with the
remaining Loan Documents, constitute the entire agreement between the parties
hereto with respect to the subject matter hereof. Neither this Agreement nor any
Loan Document may be changed, waived, discharged, modified or terminated orally,
but only by an instrument in writing signed by the party against whom
enforcement is sought.

          10.11. Time of Essence. Time is of the essence in this Agreement and
the other Loan Documents.

          10.12. Interpretation. No provision of this Agreement or any Loan
Document shall be construed against or interpreted to the disadvantage of any
party hereto by any court or other governmental or judicial authority by reason
of such party having or being deemed to have structured or dictated such
provision.

          10.13. Lender Not a Joint Venturer. Neither this Agreement nor any
Loan Document shall in any respect be interpreted, deemed or construed as making
Lender a partner or joint venturer with Borrower or as creating any similar
relationship or entity, and Borrower agrees that it will not make any contrary
assertion, contention, claim or counterclaim in any action, suit or other legal
proceeding involving Lender and Borrower.

          10.14. JURISDICTION. BORROWER AGREES THAT ANY LEGAL ACTION OR
PROCEEDING WITH RESPECT TO THIS AGREEMENT OR ANY LOAN DOCUMENT MAY BE BROUGHT IN
THE COURTS OF THE STATE OF GEORGIA OR THE UNITED STATES OF AMERICA FOR THE
NORTHERN DISTRICT OF GEORGIA, ATLANTA DIVISION, ALL AS LENDER MAY ELECT. BY
EXECUTION OF THIS AGREEMENT, BORROWER HEREBY SUBMITS TO EACH SUCH JURISDICTION,
HEREBY EXPRESSLY WAIVING WHATEVER RIGHTS MAY CORRESPOND TO IT BY REASON OF ITS
PRESENT OR FUTURE DOMICILE. NOTHING HEREIN SHALL AFFECT THE

                                       24
<PAGE>

RIGHT OF LENDER TO COMMENCE LEGAL PROCEEDINGS OR OTHERWISE PROCEED AGAINST
BORROWER IN ANY OTHER JURISDICTION OR TO SERVE PROCESS IN ANY MANNER PERMITTED
OR REQUIRED BY LAW.

          10.15. ACCEPTANCE. THIS AGREEMENT, TOGETHER WITH THE OTHER LOAN
DOCUMENTS, SHALL NOT BECOME EFFECTIVE UNLESS AND UNTIL DELIVERED TO LENDER AT
ITS PRINCIPAL OFFICE IN ATLANTA, FULTON COUNTY, GEORGIA AND ACCEPTED IN WRITING
BY LENDER AT SUCH OFFICE AS EVIDENCED BY ITS EXECUTION HEREOF (NOTICE OF WHICH
DELIVERY AND ACCEPTANCE ARE HEREBY WAIVED BY BORROWER).

          10.16. Payment on Non-Business Days. Whenever any payment to be made
hereunder or under the Notes shall be stated to be due on a Saturday, Sunday or
any other day in which national banks within the State of Georgia are legally
authorized to close, such payment may be made on the next succeeding Business
Day, and such extension of time shall in such case be included in the
computation of payment of interest hereunder or under the Notes.

          10.17. Cure of Defaults by Lender. If, hereafter, Borrower defaults in
the performance of any duty or obligation to Lender hereunder or under any Loan
Document, Lender may, at its option, but without obligation, cure such default
and any costs, fees and expenses incurred by Lender in connection therewith
including, without limitation, for the purchase of insurance, the payment of
taxes and the removal or settlement of liens and claims, shall be deemed to be
advances against the Master Note, whether or not this creates an overadvance
thereunder, and shall be payable in accordance with its terms.

          10.18. Attorney-in-Fact. Borrower hereby designates, appoints and
empowers Lender irrevocably as its attorney-in-fact, effective during any time
that an Event of Default exists, either in the name of Borrower or the name of
Lender, at Borrower's cost and expense, (i) to do any and all actions which
Lender may deem necessary or advisable to carry out the terms of this Agreement
or any other Loan Document upon the failure, refusal or inability of Borrower to
do so and (ii) to ask for, demand, sue for, collect, compromise, compound,
receive, receipt for and give acquittances for any and all sums owing or which
may become due upon any of the Collateral and, in connection therewith, to take
any and all actions as Lender may deem necessary or desirable to realize upon
any Collateral; and Borrower hereby agrees to indemnify and hold Lender harmless
from any costs, damages, expenses or liabilities arising against or incurred by
Lender directly in connection therewith, except to the extent that such damages,
expenses or liabilities arise directly from the gross negligence or willful
misconduct of Lender.

          10.19. Sole Benefit. The rights and benefits set forth in this
Agreement and the other Loan Documents are for the sole and exclusive benefit of
the parties hereto and thereto and may be relied upon only by them.

          10.20. Indemnification. Borrower will hold Lender, its respective
directors, officers, employees, agents, Affiliates, successors and assigns
harmless from and indemnify Lender, its respective directors, officers,
employees, agents, Affiliates, successors and assigns against, all loss,
damages, costs and expenses (including, without limitation, reasonable
attorney's fees, costs and expenses) actually incurred by any of the foregoing,
whether direct, indirect or consequential, as a result of or arising from or
relating to any "Proceedings" (as defined below) by any Person, whether
threatened or initiated, asserting a claim for any legal or equitable remedy
against any Person under any statute, case or regulation, including, without
limitation, any federal or state securities laws or under any common law or
equitable case or otherwise, arising from or in connection with this Agreement,
and any other of the transactions contemplated by this Agreement, except to the
extent such losses, damages, costs or expenses are due to the willful misconduct
or gross negligence of Lender. As used herein, "Proceedings" shall mean actions,
suits or proceedings before any court, governmental or regulatory authority and
shall include, particularly, but without limitation, any actions concerning
environmental laws, regulations or rules. At the request of Lender, Borrower
will indemnify any Person to whom Lender transfers or sells all or any portion
of its interest in the Obligations or participations therein on terms
substantially similar to the terms set forth above. Lender shall not be
responsible or liable to any Person for consequential damages which may be
alleged as a result of this Agreement or any of the transactions contemplated
hereby. The obligations of Borrower under this Section shall survive the
termination of this Agreement and payment of the Obligations.

                                       25
<PAGE>

          10.21. JURY TRIAL WAIVER. EACH OF BORROWER AND LENDER HEREBY WAIVES,
TO THE EXTENT PERMITTED BY APPLICABLE LAW, THE RIGHT TO TRIAL BY JURY IN ANY
ACTION, SUIT, PROCEEDING OR COUNTERCLAIM OF ANY KIND ARISING OUT OF OR RELATED
TO ANY OF THE LOAN DOCUMENTS, OBLIGATIONS OR THE COLLATERAL.

          10.22. Terminology. All personal pronouns used in this Agreement,
whether used in the masculine, feminine or neuter gender, shall include all
other genders; the singular shall include the plural, and the plural shall
include the singular. Titles of Articles and Sections in this Agreement are for
convenience only, and neither limit nor amplify the provisions of this
Agreement, and all references in this Agreement to Articles, Sections,
Subsections, paragraphs, clauses, subclauses or Exhibits shall refer to the
corresponding Article, Section, Subsection, paragraph, clause, subclause of, or
Exhibit attached to, this Agreement, unless specific reference is made to the
articles, sections or other subdivisions divisions of or Exhibit to, another
document or instrument. Wherever in this Agreement reference is made to any
instrument, agreement or other document, including, without limitation, any of
the Loan Documents, such reference shall be understood to mean and include any
and all amendments thereto or modifications, restatements, renewals or
extensions thereof. Wherever in this Agreement reference is made to any statute,
such reference shall be understood to mean and include any and all amendments
thereof and all regulations promulgated pursuant thereto. Whenever any matter
set forth herein or in any Loan Document is to be consented to or be
satisfactory to Lender, or is to be determined, calculated or approved by
Lender, then, unless otherwise expressly set forth herein or in any such Loan
Document, such consent, satisfaction, determination, calculation or approval
shall be in Lender's sole discretion, exercised in good faith and, where
required by law, in a commercially reasonable manner, and shall be conclusive
absent manifest error.

          10.23. Publicity. Lender may post notice of this transaction in trade
publications and other media, including through the use of "tombstones," and may
include Borrower's name and other selected data about the transaction of a
general nature.

     11. CONDITIONS PRECEDENT. Unless waived in writing by Lender at or prior to
the execution and delivery of this Agreement, the conditions set forth below
shall constitute express conditions precedent to any obligation of Lender
hereunder.

          11.1. Secretary's Certificate. Receipt by Lender of a certificate from
the Secretary (or Assistant Secretary) of Borrower, to be in form and substance
substantially similar to the secretary's certificate set forth on Exhibit "M".

          11.2. Good Standing Certificates. Receipt by Lender of a certificate
of good standing with respect to Borrower from the secretaries of state of the
state of incorporation of Borrower and of any state in which a Collateral
Location is situated, dated within thirty (30) days of the Closing Date.

          11.3. Loan Documents. Receipt by Lender of this Agreement and all
other Loan Documents, each duly executed by Borrower in form and substance
acceptable to Lender.

          11.4. Insurance. Receipt by Lender of a certificate respecting all
insurance required to be maintained hereunder, together with appropriate loss
payee and additional insured endorsements thereto, favoring Lender, all in form
acceptable to Lender.

          11.5. Financing Statements. Receipt by Lender of Uniform Commercial
Code financing statements respecting the Collateral, duly executed by Borrower
in respect of each Collateral Location, in form and substance acceptable to
Lender, but, in any event, including the property description set forth on
Exhibit "N".

          11.6. Opinions of Counsel. Receipt by Lender of opinions of counsel
from independent legal counsel to Borrower and Parent in substantially the form
of Exhibit "O".

          11.7. Landlord Agreements. Receipt by Lender of any Landlord
Agreements then obtained by Borrower with respect to Collateral Locations leased
by Borrower as of the Closing Date.

                                       26
<PAGE>

          11.8. Disbursements Letter. Receipt by Lender of a disbursements
letter, concerning the use of the proceeds of the initial extensions of credit
hereunder, to be substantially in the form of Exhibit "P" attached hereto.

          11.9. Payoff Letter. Receipt by Lender from the Existing Lender of a
payoff letter, to be substantially in the form of Exhibit "Q", together with, if
such Debt is secured by any Collateral, termination statements respecting the
Lien(s) of such creditor.

          11.10. Initial Borrowing Base and Collateral Status Reports. Receipt
by Lender of a Borrowing Base Report, certified as to truth and accuracy by a
duly authorized officer of Borrower, together with accompanying documentation
required by Lender (each in form and substance required by Lender, but to
include in any event an accounts receivable and accounts payable aging and a
current customer and Account Debtor name and address list) which shall indicate,
after giving effect to the making of the initial Advance (and the issuance of
any initial Letter(s) of Credit) not less than $600,000 in additional Borrowings
available under the Borrowing Base Requirement.

          11.11. Blocked Account. Receipt by Lender of a duly executed Blocked
Account Agreement in conjunction with the establishment of each Lockbox Account.

          11.12. Parent Guaranty and Subordination Agreement. Receipt by Lender
from Parent of the Guaranty and the Subordination Agreement; each duly executed
by Parent.

          11.13. Satisfactory Inventory Appraisal. Receipt by Lender of an
inventory audit (as to cost and market price), completed by an independent
appraiser selected (and paid for) by Borrower (but acceptable to Lender), to be
in form and substance satisfactory to Lender.

          11.14. Business Plan. Receipt by Lender of a business plan of Borrower
for the twelve (12) months' period following the Closing Date, including
financial projections, to be in form and substance satisfactory to Lender.

          11.15. Environmental Review. Receipt by Lender of satisfactory
evidence that there are no existing or potential environmental liabilities that
would have a material adverse impact on the financial condition or prospects of
Borrower.

          11.16. Logistics. Receipt by Lender of satisfactory evidence that
Borrower and Logistics shall have entered into the Logistics Contract.

          11.17. Other. Receipt by Lender of such other documents, certificates,
instruments and agreements as shall be required hereunder or provided for herein
or as Lender or Lender's counsel may require in connection herewith.

                                       27
<PAGE>

         IN WITNESS WHEREOF, Borrower has caused this Agreement to be executed
as of the day and year set forth below as the Closing Date.

                                   "BORROWER"

                                   HAEMACURE CORPORATION, a Delaware corporation

                                   By: /s/ James L. Roberts
                                      ------------------------------------------
                                   Name:  James L. Roberts
                                   Title: Vice President, Finance and
                                          Chief Financial Officer

                                       28
<PAGE>

     Accepted by Lender in Atlanta, Georgia

                                        as of November 20, 2001
                                        (the "Closing Date")

                                        "LENDER"

                                        UPS CAPITAL CORPORATION

                                        By: /s/ Charles Johnson
                                           -------------------------------------
                                        Name:
                                             -----------------------------------
                                        Title:
                                             -----------------------------------

                                        Address for Notices:

                                        35 Glenlake Parkway, N.E.
                                        Suite 360
                                        Atlanta, GA 30328
                                        Attn: Legal Department

                        [Exhibits and schedules omitted]

                                       29

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