Document:

Exhibit 4.1

 

PLURISTEM THERAPEUTICS
INC.

_________________________________________________________________

 

AMENDED AND RESTATED
ARTICLES OF INCORPORATION

_________________________________________________________________

 

As amended as of
July 2, 2020

 

FIRST

 

The name of this
corporation is PLURISTEM THERAPEUTICS INC.

 

SECOND

 

Its principal
office in the State of Nevada is located at 502 East John Street, Carson City, Nevada, 89706. The name and address of its resident
agent is CSC Services of Nevada, Inc., at the above address.

 

THIRD

 

The purpose or
purposes for which the corporation is organized:

 

To engage in and
carry on any lawful business activity or trade, and any activities necessary, convenient, or desirable to accomplish such purposes,
not forbidden by law or by these articles of incorporation.

 

FOURTH

 

The aggregate
number of shares which the corporation shall have authority to issue is: (i) Sixty Million (60,000,000) shares
of Common Stock, par value $0.00001 each (the “Common Stock”), and (ii) One Million (1,000,000)
shares of preferred stock, par value $0.00001 each, which may be issued in one or more series at the discretion of the Board of
Directors (the “Preferred Stock”). The Board of Directors is hereby vested with authority to fix
by resolution or resolutions the designations and the powers, preferences and relative, participating, optional or other special
rights, and qualifications, limitations or restrictions thereof, including without limitation the dividend rate, conversion or
exchange rights, redemption price and liquidation preference, of any series of shares of Preferred Stock, and to fix the number
of shares constituting any such series, and to increase or decrease the number of shares of any such series (but not below the
number of shares thereof then outstanding).  In case the number of shares of any such series shall be so decreased, the
shares constituting such decrease shall resume the status which they had prior to the adoption of the resolution or resolutions
originally fixing the number of shares of such series. All shares of any one series shall be alike in every particular except
as otherwise provided by these Articles of Incorporation or the Nevada Revised Statues.

 

FIFTH

 

The governing
board of this corporation shall be known as directors, and the number of directors may from time to time be increased or decreased
in such manner as shall be provided by the bylaws of this corporation.

 

There are two
members of the Board of Directors at the date of filing these Restated Articles of Incorporation and their names and postal addresses
are:

 

	NAME	 	POST OFFICE ADDRESS
	 	 	 
	Harvey M.J. Lawson	 	464 Somerset St., North Vancouver, B.C., Canada V7N1G3
	 	 	 
	John Carl Guterres	 	#1408 - 1327 E. Keith Rd., North Vancouver, B.C., Canada V7J 3T5

 

The number of
members of the Board of Directors shall not be less than one nor more than thirteen.

 

     

     

    

 

SIXTH

 

The capital stock,
after the amount of the subscription price, or par value, has been paid in shall not be subject to assessment to pay the debts
of the corporation.

 

SEVENTH

 

The corporation
is to have perpetual existence.

 

EIGHTH

 

In furtherance,
and not in limitation of the powers conferred by statute, the board of directors is expressly authorized:

 

Subject to the
bylaws, if any, adopted by the stockholders, to make, alter, amend or repeal the bylaws of the corporation.

 

To fix the amount
to be reserved as working capital over and above its capital stock paid in, to authorize and cause to be executed mortgages and
liens upon the real and personal property of this corporation.

 

To authorize the
guaranty by the corporation of the securities, evidences of indebtedness and obligations of other persons, corporations or business
entities.

 

To set apart out
of any funds of the corporation available for dividends a reserve or reserves for any proper purpose and to abolish any such reserve.

 

By resolution
passed by a majority of the whole board, to designate one (1) or more committees, each committee to consist of one (1) or more
of the directors of the corporation, which, to the extent provided in the resolution or in the bylaws of the corporation, shall
have and may exercise the powers of the board of directors in the management of the business and affairs of the corporation, and
may authorize the seal of the corporation to be affixed to all papers which may require it. Such committee or committees shall
have such name or names as may be stated in the bylaws of the corporation or as may be determined from time to time by resolution
adopted by the board of directors.

 

When and as authorized
by the affirmative vote of stockholders holding stock entitling them to exercise at least a majority of the voting power given
at a stockholders’ meeting called for that purpose, or when authorized by the written consent of the holders of at least
a majority of the voting stock issued and outstanding, the board of directors shall have power and authority at any meeting to
sell, lease or exchange all of the property and assets of the corporation, including its good will and its corporate franchises,
upon such terms and conditions as its board of directors deem expedient and for the best interests of the corporation.

 

All the corporate
powers of the corporation shall be exercised by the board of directors except as otherwise herein or in the bylaws or by law.

 

NINTH

 

Meeting of stockholders
may be held outside the State of Nevada, if the bylaws so provide. The books of the corporation may be kept (subject to any provision
contained in the statutes) outside the State of Nevada at such place or places as may be designated from time to time by the board
of directors or in the bylaws of the corporation.

 

TENTH

 

This corporation
reserves the right to amend alter, change or repeal any provision contained in the Restated Articles of Incorporation, in the manner
now or hereafter prescribed by statute, or by the Restated Articles of Incorporation, and all rights conferred upon stockholders
herein are granted subject to this reservation.

 

    2

     

    

 

ELEVENTH

 

The corporation
shall indemnify its officers, directors, employees and agents to the full extent permitted by the laws of the State of Nevada.

 

A director or
officer of the corporation shall not be personally liable to the corporation or its stockholders for damages for breach of fiduciary
duty as a director or officer, but this article shall not eliminate or limit the liability of a director or officer for (i) acts
or omissions which involve intentional misconduct, fraud or a knowing violation of the law or (ii) the unlawful payment of dividends.
Any repeal or modification of this article by stockholders of the corporation shall be prospective only, and shall not adversely
affect any limitation on the personal liability of a director or officer of the corporation for acts or omissions prior to such
repeal or modification.

 

TWELFTH

 

Every person who
was or is a party to, or is threatened to be made a party to, or is involved in any such action, suit or proceeding, whether civil,
criminal, administrative or investigative, by the reason of the fact that he or she, or a person with whom he or she is a legal
representative, is or was a director of the corporation, or who is serving at the request of the corporation as a director or officer
of another corporation, or is a representative in a partnership, joint venture, trust or other enterprise, shall be indemnified
and held harmless to the fullest extent legally permissible under the laws of the State of Nevada from time to time against all
expenses, liability and loss (including attorneys’ fees, judgments, fines, and amounts paid or to be paid in a settlement)
reasonably incurred or suffered by him or her in connection therewith. Such right of indemnification shall be a contract right
which may be enforced in any manner desired by such person. The expenses of officers and directors incurred in defending a civil
suit or proceeding must be paid by the corporation as incurred and in advance of the final disposition of the action, suit, or
proceeding, under receipt of an undertaking by or on behalf of the director or officer to repay the amount if it is ultimately
determined by a court of competent jurisdiction that he or she is not entitled to be indemnified by the corporation. Such right
of indemnification shall not be exclusive of any other right of such directors, officers or representatives may have or hereafter
acquire, and, without limiting the generality of such statement, they shall be entitled to their respective rights of indemnification
under any bylaw, agreement, vote of stockholders, provision of law, or otherwise, as well as their rights under this article.

 

Without limiting
the application of the foregoing, the board of directors may adopt by-laws from time to time with respect to indemnification, to
provide at all times the fullest indemnification permitted by the laws of the State of Nevada, and may cause the corporation to
purchase or maintain insurance on behalf of any person who is or was a director or officer.

 

 

3Exhibit 4.2

 

PLURISTEM THERAPEUTICS INC.

_________________________________________________________________

 

AMENDED AND RESTATED
ARTICLES OF INCORPORATION

_________________________________________________________________

 

As amended as of
July 25, 2019 July 2, 2020

 

FIRST

 

The name of this
corporation is PLURISTEM THERAPEUTICS INC.

 

SECOND

 

Its principal
office in the State of Nevada is located at 502 East John Street, Carson City, Nevada, 89706. The name and address of its resident
agent is CSC Services of Nevada, Inc., at the above address.

 

THIRD

 

The purpose or
purposes for which the corporation is organized:

 

To engage in and
carry on any lawful business activity or trade, and any activities necessary, convenient, or desirable to accomplish such purposes,
not forbidden by law or by these articles of incorporation.

 

FOURTH

 

The aggregate
number of shares which the corporation shall have authority to issue is: (i) Thirty Sixty Million (3060,000,000) shares
of Common Stock, par value $0.00001 each (the “Common Stock”), and (ii) One Million (1,000,000)
shares of preferred stock, par value $0.00001 each, which may be issued in one or more series at the discretion of the Board of
Directors (the “Preferred Stock”). The Board of Directors is hereby vested with authority to fix
by resolution or resolutions the designations and the powers, preferences and relative, participating, optional or other special
rights, and qualifications, limitations or restrictions thereof, including without limitation the dividend rate, conversion or
exchange rights, redemption price and liquidation preference, of any series of shares of Preferred Stock, and to fix the number
of shares constituting any such series, and to increase or decrease the number of shares of any such series (but not below the
number of shares thereof then outstanding).  In case the number of shares of any such series shall be so decreased, the
shares constituting such decrease shall resume the status which they had prior to the adoption of the resolution or resolutions
originally fixing the number of shares of such series. All shares of any one series shall be alike in every particular except
as otherwise provided by these Articles of Incorporation or the Nevada Revised Statues.

 

FIFTH

 

The governing
board of this corporation shall be known as directors, and the number of directors may from time to time be increased or decreased
in such manner as shall be provided by the bylaws of this corporation.

 

There are two
members of the Board of Directors at the date of filing these Restated Articles of Incorporation and their names and postal addresses
are:

 

	NAME	 	POST OFFICE ADDRESS
	 	 	 
	Harvey M.J. Lawson	 	464 Somerset St., North Vancouver, B.C., Canada V7N1G3
	 	 	 
	John Carl Guterres	 	#1408 - 1327 E. Keith Rd., North Vancouver, B.C., Canada V7J 3T5

 

The number of
members of the Board of Directors shall not be less than one nor more than thirteen.

 

     

     

    

 

SIXTH

 

The capital stock,
after the amount of the subscription price, or par value, has been paid in shall not be subject to assessment to pay the debts
of the corporation.

 

SEVENTH

 

The corporation
is to have perpetual existence.

 

EIGHTH

 

In furtherance,
and not in limitation of the powers conferred by statute, the board of directors is expressly authorized:

 

Subject to the
bylaws, if any, adopted by the stockholders, to make, alter, amend or repeal the bylaws of the corporation.

 

To fix the amount
to be reserved as working capital over and above its capital stock paid in, to authorize and cause to be executed mortgages and
liens upon the real and personal property of this corporation.

 

To authorize the
guaranty by the corporation of the securities, evidences of indebtedness and obligations of other persons, corporations or business
entities.

 

To set apart out
of any funds of the corporation available for dividends a reserve or reserves for any proper purpose and to abolish any such reserve.

 

By resolution
passed by a majority of the whole board, to designate one (1) or more committees, each committee to consist of one (1) or more
of the directors of the corporation, which, to the extent provided in the resolution or in the bylaws of the corporation, shall
have and may exercise the powers of the board of directors in the management of the business and affairs of the corporation, and
may authorize the seal of the corporation to be affixed to all papers which may require it. Such committee or committees shall
have such name or names as may be stated in the bylaws of the corporation or as may be determined from time to time by resolution
adopted by the board of directors.

 

When and as authorized
by the affirmative vote of stockholders holding stock entitling them to exercise at least a majority of the voting power given
at a stockholders’ meeting called for that purpose, or when authorized by the written consent of the holders of at least
a majority of the voting stock issued and outstanding, the board of directors shall have power and authority at any meeting to
sell, lease or exchange all of the property and assets of the corporation, including its good will and its corporate franchises,
upon such terms and conditions as its board of directors deem expedient and for the best interests of the corporation.

 

All the corporate
powers of the corporation shall be exercised by the board of directors except as otherwise herein or in the bylaws or by law.

 

NINTH

 

Meeting of stockholders
may be held outside the State of Nevada, if the bylaws so provide. The books of the corporation may be kept (subject to any provision
contained in the statutes) outside the State of Nevada at such place or places as may be designated from time to time by the board
of directors or in the bylaws of the corporation.

 

TENTH

 

This corporation
reserves the right to amend alter, change or repeal any provision contained in the Restated Articles of Incorporation, in the manner
now or hereafter prescribed by statute, or by the Restated Articles of Incorporation, and all rights conferred upon stockholders
herein are granted subject to this reservation.

 

    2

     

    

 

ELEVENTH

 

The corporation
shall indemnify its officers, directors, employees and agents to the full extent permitted by the laws of the State of Nevada.

 

A director or
officer of the corporation shall not be personally liable to the corporation or its stockholders for damages for breach of fiduciary
duty as a director or officer, but this article shall not eliminate or limit the liability of a director or officer for (i) acts
or omissions which involve intentional misconduct, fraud or a knowing violation of the law or (ii) the unlawful payment of dividends.
Any repeal or modification of this article by stockholders of the corporation shall be prospective only, and shall not adversely
affect any limitation on the personal liability of a director or officer of the corporation for acts or omissions prior to such
repeal or modification.

 

TWELFTH

 

Every person who
was or is a party to, or is threatened to be made a party to, or is involved in any such action, suit or proceeding, whether civil,
criminal, administrative or investigative, by the reason of the fact that he or she, or a person with whom he or she is a legal
representative, is or was a director of the corporation, or who is serving at the request of the corporation as a director or officer
of another corporation, or is a representative in a partnership, joint venture, trust or other enterprise, shall be indemnified
and held harmless to the fullest extent legally permissible under the laws of the State of Nevada from time to time against all
expenses, liability and loss (including attorneys’ fees, judgments, fines, and amounts paid or to be paid in a settlement)
reasonably incurred or suffered by him or her in connection therewith. Such right of indemnification shall be a contract right
which may be enforced in any manner desired by such person. The expenses of officers and directors incurred in defending a civil
suit or proceeding must be paid by the corporation as incurred and in advance of the final disposition of the action, suit, or
proceeding, under receipt of an undertaking by or on behalf of the director or officer to repay the amount if it is ultimately
determined by a court of competent jurisdiction that he or she is not entitled to be indemnified by the corporation. Such right
of indemnification shall not be exclusive of any other right of such directors, officers or representatives may have or hereafter
acquire, and, without limiting the generality of such statement, they shall be entitled to their respective rights of indemnification
under any bylaw, agreement, vote of stockholders, provision of law, or otherwise, as well as their rights under this article.

 

Without limiting
the application of the foregoing, the board of directors may adopt by-laws from time to time with respect to indemnification, to
provide at all times the fullest indemnification permitted by the laws of the State of Nevada, and may cause the corporation to
purchase or maintain insurance on behalf of any person who is or was a director or officer.

 

 

3

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