Document:

<PAGE>
                              CONSULTING AGREEMENT

     THIS CONSULTING AGREEMENT is made and entered into as of the 1st day of
May, 2004 by and between Vascular Sciences Corporation, a Delaware corporation
(the "Company"), and Richard C. Davis, Jr., M.D. (the "Consultant").

                              W I T N E S S E T H:

     WHEREAS, the Company desires that the Consultant provide advice and counsel
to the Company concerning various matters associated with its business.

     NOW, THEREFORE, in consideration of the premises and the mutual covenants
contained herein, the parties agree as follows:

     1.   Description of Services. The Company hereby engages the Consultant to
provide advice and counsel to the Company on matters related to its business and
shall have such other duties as may from time to time be reasonably assigned to
him by the President of the Company.

     2.   Term. The term of this Agreement shall begin as of the date set forth
above and shall terminate on April 30, 2005.

     3.   Fee. The fee for services provided in accordance with this Agreement
will be a base fee of $6,250 per month, subject to such reductions as may be
agreed upon by the parties or required by law. The Company shall also pay to the
Consultant a cash bonus in the amount of $2,083 monthly. Such amounts shall be
payable on or before the 15th day of each month with respect to the preceding
calendar month. The Consultant shall be reimbursed for all usual and customary
out-of-pocket expenses incurred as the result of any and all business-related
activities pursuant to this Agreement, in accordance with a uniform policy
established by the Board of Directors of the Company from time to time;
provided, however, that reimbursement under this Section shall not be made until
and unless the Consultant has furnished the Company with an appropriate receipt
or such other documents as may be reasonably required by the Company to
substantiate the nature and amount of the expenses incurred by the Consultant.

     4.   Termination without Cause. The Consultant or the Company may
voluntarily elect to terminate this Agreement without cause by delivering to the
other party, at least sixty (60) days prior to the date upon which termination
is desired, written notice of such intention to terminate; provided, however,
that, the Company shall have the right to relieve the Consultant, in whole or in
part, of his duties under this Agreement (without reduction in compensation) or
to accelerate the date of termination, with compensation to the Consultant
payable only to the date of termination.

     5.   Relationship of Parties.

          (a) The parties intend that an independent contractor relationship be
created by this Agreement. The conduct and control of the work will lie solely
with the Consultant. The Consultant shall perform such work in accordance with
currently approved methods and procedures for consulting services
<PAGE>
          (b)  The Consultant shall not be considered an agent or employee of
the Company for any purpose and will not be entitled to any of the benefits the
Company provides for its employees.

     6.   Prior Agreement. The parties agree that the Employment Agreement
between the parties is hereby terminated; provided, however, that the provisions
of Sections 9 through 14 of such Employment Agreement shall continue in effect
and shall be deemed incorporated by reference into this Agreement.

     7.   Governing Law. This Agreement shall be construed and enforced in
accordance with the laws of the State of Florida. Furthermore, the parties to
this Agreement acknowledge and confirm that the proper, exclusive and
convenient venue for any legal proceeding instituted in connection with this
Agreement, and with respect to any rights and liabilities hereunder, shall be
Pinellas County, Florida, and each party waives any defense, whether asserted
by motion or pleading, that Pinellas County, Florida is an improper or
inconvenient venue, and each party hereby consents to the personal jurisdiction
of any court of competent jurisdiction located in Pinellas County, Florida.

     8.   Arbitration. The Company and the Consultant agree that any dispute or
controversy arising out of, in relation to, or in connection with this
Agreement, or the making, interpretation, construction, performance or breach
thereof, shall be finally settled by binding arbitration under the then current
rules of the American Arbitration Association by one (1) arbitrator appointed
in accordance with such rules. The arbitrator may grant injunctive or other
relief in such dispute or controversy. The decision of the arbitrator shall be
final, conclusive and binding on the parties to the arbitration. Judgment may
be entered on the arbitrator's decision in any court of competent jurisdiction.
The parties agree that, any provision of applicable law notwithstanding, they
will not request, and the arbitrator shall have no authority to award, punitive
or exemplary damages against any party. The costs of the arbitration, including
administrative and arbitrator's fees, attorneys, fees and expert witness fees
shall be borne by the nonprevailing party.

     IN WITNESS WHEREOF, the parties have executed this Consulting Agreement as
of the day and date first above written.

                                             Vascular Sciences Corporation

                                             By: /s/ Elias Vamvakas
                                                 --------------------------
                                                 Elias Vamvakas

                                                   /s/ Richard Davis
                                             ------------------------------
                                               Richard C. Davis, Jr., M.D.

                                       2<PAGE>
                            REIMBURSEMENT AGREEMENT

     THIS REIMBURSEMENT AGREEMENT is made and entered into as of the 25th day
of June, 2003 by and between Apheresis Technologies Technologies Inc. ("ATI")
and Vascular Sciences Corporation ("VSC").

                             W I T N E S S E T H :

     WHEREAS, ATI employs and compensates John Cornish ("Cornish") and Sue
Howard ("Howard") as full-time employees; and

     WHEREAS, Cornish and Howard spend substantial amounts of their working
time providing services on behalf of VSC; and

     WHEREAS, the parties desire to reduce to writing the arrangement by which
VSC reimburses ATI for such services.

     NOW, THEREFORE, in consideration of the premises and the covenants
contain, the parties agree as follows:

     1.   Reimbursement.  Subject to the limitations set forth in this
Agreement, VSC will reimburse ATI for 80% of all remuneration (including
without limitation salary, benefits, bonus, severance, etc.) paid by ATI to
Cornish and Howard. Such reimbursement shall be payable to ATI within 7 days of
receiving a summary of monthly reimburseable costs incurred by ATI for Cornish
and Howard. All amounts paid to ATI hereunder shall promptly be used to pay
compensation or benefits, as appropriate, to or on behalf of Cornish and Howard.

     2.   Cornish.  VSC's reimbursement with respect to Cornish shall be based
upon an annual salary level for Cornish of $100,000 (ie. $80,000 annually
reimburseable by VSC). In addition, Cornish shall be eligible to participate in
a VSC bonus plan that is currently being developed. VSC shall not be obliged to
reimburse ATI for any portion of a bonus paid other than in accordance with
such bonus plan.

     3.   Howard.  VSC's reimbursement with respect to Howard shall be based
upon an annual salary level for Howard of $52,500 (ie. $42,000 annually
reimburseable by VSC). In addition, Howard shall be eligible for payment of up
to $2,500 ($2,000 reimburseable by VSC) as part of a VSC bonus plan that is
currently being developed. VSC shall not be obligated to reimburse ATI for any
portion of a bonus paid other than in accordance with such bonus plan.

     4.  Term; Termination.  This Agreement shall be effective as of June 25,
2003, and shall continue in force for a period of three years. Notwithstanding

<PAGE>
the foregoing, either party may terminate this agreement on 30 days' prior
written notice.

     5.   Severance.  In the event that VSC ceases to use the services of
Cornish and/or Howard or terminates this agreement other than for cause, VSC
will reimburse ATI $40,000 as severance for Cornish if Cornish's services are
no longer used or the agreement is terminated and $21,000 as severance for
Howard if Howard's services are no longer used or the agreement is terminated,
in addition to any other amounts due hereunder as of the date of termination.

     IN WITNESS WHEREOF, the parties have caused this Agreement to be executed,
as of the date first above written.

                                      Vascular Sciences Corporation

                                      By:  /s/ Elias Vamvakas
                                           ----------------------------------

                                      Apheresis Technologies Inc.

                                      By:  /s/ John Cornish
                                           ----------------------------------<PAGE>

                                    AMENDMENT

         THIS AMENDMENT is made and entered into as of the 1st day of July,
2003, by and between The Center for Clinical Research by and through Donald R.
Sanders, M.D. Ph.D. ("CCR") and Vascular Sciences Corporation, a Delaware
corporation ("VSC").

                              W I T N E S S E T H:

         WHEREAS, CCR has provided services for VSC pursuant to a Consultancy
and Non-Compete Agreement effective as of January 1, 1998 (as amended to date,
the "Agreement"); and

         WHEREAS, VSC owes CCR $301,000 (the "Balance") under the Agreement as
of this date; and

         WHEREAS, the parties desire to amend the Agreement in certain respects
and to provide for the payment over time of the Balance.

         NOW, THEREFORE, in consideration of the premises and the mutual
covenants contained herein, the parties agree as follows:

         1.       Within 30 days after execution of this Agreement, VSC shall
                  pay to CCR $75,250 in partial payment of the Balance.

         2.       Beginning in July 2003, and continuing each month thereafter
                  through and including January 2005, VSC shall make monthly
                  payments of $7,500 per month to CCR in partial payment of the
                  Balance. Final payment of $8,000 will be made in February
                  2005.

         3.       The remainder of the Balance shall be discharged in full by
                  the grant to CCR of options to purchase 20,926 shares of VSC
                  common stock at an exercise price of $0.13 per share, which
                  options (i) shall be fully vested immediately and (ii) shall
                  expire 10 years from the date hereof. Such options shall be
                  evidenced by an option agreement in the form customarily used
                  by VSC.

         4.       The Agreement is hereby renewed through December 2005;
                  provided, however, that in lieu of the compensation set forth
                  in the Agreement, VSC shall pay CCR a monthly fee of $5,000
                  per month payable each month, commencing July 2003. Such fee
                  shall be fixed, regardless of the amount of time incurred by
                  CCR in performance of the services rendered to VSC.
                  Notwithstanding the foregoing, upon 30 days' prior written
                  notice, either party may convert the payment arrangement to a
                  daily fee of $2,500 per day. In the event of such conversion,
                  CCR shall provide services on a daily basis as requested by
                  VSC, and will invoice VSC for the total number of days of
                  service provided in the month. VSC shall pay the monthly
                  invoice within a reasonable period of time after receipt of a
                  monthly invoice.

<PAGE>

                                       -2-

         5.       Except for the collection of the Balance on the terms provided
                  in this Amendment, CCR agrees that VSC has fulfilled all
                  obligations under the Agreement as of this date.

         IN WITNESS WHEREOF, the parties have executed this agreement as of the
date first above written.

                                          THE CENTER FOR CLINICAL RESEARCH

                                          By: /s/ Donald R. Sanders
                                              ----------------------------------
                                              Donald R. Sanders, M.D. Ph.D

                                          VASCULAR SCIENCES CORPORATION

                                          By: /s/ Bill Dumencu
                                              ----------------------------------
                                              Bill Dumencu

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00075-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00075-of-00352.parquet"}], [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00075-of-00352.parquet"}]]