Document:

Standard Industrial/Commercial Multi-Tenant Lease

 Exhibit 10.12 
 

 
 STANDARD INDUSTRIAL/COMMERCIAL MULTI-TENANT LEASE – NET 

AMERICAN INDUSTRIAL REAL ESTATE ASSOCIATION 

1. Basic Provisions (“Basic Provisions”). 

1.1 Parties: This Lease (“Lease”), dated for reference purposes only September 7 , 2004, is
made by and between Nancy Ridge Technology Center, L.P., a California Limited Partnership (“Lessor”) and RexC Pharmaceuticals, Inc., a California corporation (“Lessee”), (collectively the
“Parties”, or individually a “Party”). 
 1.2(a) Premises: That certain portion
of the Project (as defined below), including all improvements therein or to be provided by Lessor under the terms of this Lease, commonly known by the street address of 6310 Nancy Ridge Drive, Suite #105, located in the City of San
Diego, County of San Diego, State of California, with zip code 92121, as outlined on Exhibit B & C attached hereto (“Premises”) and generally described as (describe briefly the nature of the
Premises): Approximately 5,803 square feet of office and biotech lab space. In addition to Lessee’s rights to use and occupy the Premises as hereinafter specified, Lessee shall have non-exclusive rights to the Common Areas (as defined in
Paragraph 2.7 below) as hereinafter specified, but shall not have any rights to the roof, exterior walls or utility raceways of the building containing the Premises (“Building”) or to any other buildings in the Project. The
Premises, the Building, the Common Areas, the land upon which they are located, along with all other buildings and improvements thereon, are herein collectively referred to as the “Project.” (See also Paragraph 2) 

1.2(b) Parking: Pro rata share of unreserved vehicle parking spaces (“Unreserved Parking Spaces”);
and No reserved vehicle parking spaces (“Reserved Parking Spaces”). (See also Paragraph 2.6) 

1.3 Term: Two (2) years and No months (“Original Term”) commencing September 1,
2004 (“Commencement Date”) and ending August 31, 2006 (“Expiration Date”). (See also Paragraph 3) 

1.4 Early Possession: Upon full execution of Lease (“Early Possession Date”). (See also
Paragraphs 3.2 and 3.3) 
 1.5 Base Rent: $4,874.52 per month (“Base Rent”), payable on the
first (1st) day of each month commencing August 15, 2004. (See also Paragraph 4) 

þ
 If this box is checked, there are provisions in this Lease for the Base Rent to be adjusted. 
 1.6
Lessee’s Share of Common Area Operating Expenses: three point three percent (3.3%) (“Lessee’s Share”). 

1.7 Base Rent and Other Monies Paid Upon Execution: 

(a) Base Rent: $4,874.52 for the period September 2004. 

(b) Common Area Operating Expenses: $1,450.00 for the period September 2004. 

(c) Security Deposit: $9,749.04 (“Security Deposit”). (See also Paragraph 5) 

(d) Other: $             for
                                        
. 
 (e) Total Due Upon Execution of this Lease: $16,073.56. 

1.8 Agreed Use: General office, biotech research and development. Lessee shall not create any health or safety risks,
odors, or nuisance to any other tenants in the project; nor preclude, nor limit any other present or future tenant’s use of space. (See also Paragraph 6) 

1.9 Insuring Party. Lessor is the “Insuring Party”. (See also Paragraph 8) 

1.10 Real Estate Brokers: (See also Paragraph 15) 

(a) Representation: The following real estate brokers (the “Brokers”) and brokerage relationships exist in
this transaction (check applicable boxes): 

þ
 Phase 3 Properties represents Lessor exclusively (“Lessor’s Broker”); 

þ
 CB Richard Ellis represents Lessee exclusively (“Lessee’s Broker”); or 

 ̈

                                        
represents both Lessor and Lessee (“Dual Agency”). 
 (b) Payment to Brokers: Upon execution and
delivery of this Lease by both Parties, Lessor shall pay to the Brokers the brokerage fee agreed to in a separate written agreement (or if there is no such agreement, the sum of
             or      % of the total Base Rent for the brokerage services
rendered by the Brokers). Half of this fee will be paid upon execution of this lease by both parties, and the other half will be paid once Lessee has taken possession of the premises and begun paying full rent. Broker shall not be paid on
any lease extensions, options or expansions, or any space subleased to Perlan. 
 1.11 Guarantor. The
obligations of the Lessee under this Lease are to be guaranteed by
                                     
    (“Guarantor”). (See also Paragraph 37) 

1.12 Addenda and Exhibits. Attached hereto is an Addendum or Addenda consisting of Paragraphs 50 through 63
and Exhibits A through C, all of which constitute a part of this Lease. 
 2. Premises. 

2.1 Letting. Lessor hereby leases to Lessee, and Lessee hereby leases from Lessor, the Premises, for the term, at the
rental, and upon all of the terms, covenants and conditions set forth in this Lease. Unless otherwise provided herein, any statement of size set forth in this Lease, or that may have been used in calculating Rent, is an approximation which the
Parties agree is reasonable and any payments based thereon are not subject to revision whether or not the actual size is more or less. 

2.2 Condition. Lessor shall deliver that portion of the Premises contained within the Building (“Unit”) to
Lessee broom clean and free of debris on the Commencement Date or the Early Possession Date, whichever first occurs (“Start Date”), and, so long as the required service contracts described in Paragraph 7.1(b) below are obtained by
Lessee and in effect within thirty days following the Start Date, warrants that the existing electrical, plumbing, fire sprinkler, lighting, heating, ventilating and air conditioning systems (“HVAC”), loading doors, if any, and all
other such elements in the Unit, other than those constructed by Lessee, shall be in good operating condition on said date and that the structural elements of the roof, bearing walls and foundation of the Unit shall be free of material defects. If a
non-compliance with such warranty exists as of the Start Date, or if one of such systems or elements should malfunction or fail within the appropriate warranty period, Lessor shall, as Lessor’s sole obligation with respect to such matter,
except as otherwise provided in this Lease, promptly after receipt of written notice from Lessee setting forth with specificity the nature and extent of such 

 

									
		 		  		  		  	
	 	 		  		  		  	 
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non-compliance, malfunction or failure, rectify same at Lessor’s expense. The warranty periods shall be as follows: (i) 6 months as to the HVAC systems, and (ii) 30 days as to the
remaining systems and other elements of the Unit. If Lessee does not give Lessor the required notice within the appropriate warranty period, correction of any such non-compliance, malfunction or failure shall be the obligation of Lessee at
Lessee’s sole cost and expense (except for the repairs to the fire sprinkler systems, roof, foundations, and/or bearing walls - see Paragraph 7). 

2.3 Compliance. Lessor warrants that to the best of Lessor’s actual knowledge and without duty to investigate, the
improvements on the Premises and the Common Areas comply with the building codes that were in effect at the time that each such improvement, or portion thereof, was constructed, and also with all applicable laws, covenants or restrictions of record,
regulations, and ordinances in effect on the Start Date (“Applicable Requirements”). Said warranty does not apply to the use to which Lessee will put the Premises or to any Alterations or Utility Installations (as defined in
Paragraph 7.3(a)) made or to be made by Lessee. NOTE: Lessee is responsible for determining whether or not the Applicable Requirements, and especially the zoning, are appropriate for Lessee’s intended use, and acknowledges that past uses
of the Premises may no longer be allowed. If the Premises do not comply with said warranty, Lessor shall, except as otherwise provided, promptly after receipt of written notice from Lessee setting forth with specificity the nature and extent of such
non-compliance, rectify the same at Lessor’s expense. If Lessee does not give Lessor written notice of a non-compliance with this warranty within 6 months following the Start Date, correction of that non-compliance shall be the obligation of
Lessee at Lessee’s sole cost and expense. If the Applicable Requirements are hereafter changed so as to require during the term of this Lease the construction of an addition to or an alteration of the Unit, Premises and/or Building, the
remediation of any Hazardous Substance, or the reinforcement or other physical modification of the Unit, Premises and/or Building (“Capital Expenditure”), Lessor and Lessee shall allocate the cost of such work as follows:

 (a) Subject to Paragraph 2.3(c) below, if such Capital Expenditures are required as a result of the specific and unique
use of the Premises by Lessee as compared with uses by tenants in general, Lessee shall be fully responsible for the cost thereof, provided, however that if such Capital Expenditure is required during the last 2 years of this Lease and the cost
thereof exceeds 6 months’ Base Rent, Lessee may instead terminate this Lease unless Lessor notifies Lessee, in writing, within 10 days after receipt of Lessee’s termination notice that Lessor has elected to pay the difference between the
actual cost thereof and the amount equal to 6 months’ Base Rent. If Lessee elects termination, Lessee shall immediately cease the use of the Premises which requires such Capital Expenditure and deliver to Lessor written notice specifying a
termination date at least 90 days thereafter. Such termination date shall, however, in no event be earlier than the last day that Lessee could legally utilize the Premises without commencing such Capital Expenditure. 

(b) If such Capital Expenditure is not the result of the specific and unique use of the Premises by Lessee (such as, governmentally
mandated seismic modifications), then Lessor and Lessee shall allocate the obligation to pay for the portion of such costs reasonably attributable to the Premises pursuant to the formula set out in Paragraph 7.1(d); provided, however, that if such
Capital Expenditure is required during the last 2 years of this Lease or if Lessor reasonably determines that it is not economically feasible to pay its share thereof, Lessor shall have the option to terminate this Lease upon 90 days prior written
notice to Lessee unless Lessee notifies Lessor, in writing, within 10 days after receipt of Lessor’s termination notice that Lessee will pay for such Capital Expenditure. If Lessor does not elect to terminate, and fails to tender its share of
any such Capital Expenditure, Lessee may advance such funds and deduct same, with Interest, from Rent until Lessor’s share of such costs have been fully paid. If Lessee is unable to finance Lessor’s share, or if the balance of the Rent due
and payable for the remainder of this Lease is not sufficient to fully reimburse Lessee on an offset basis, Lessee shall have the right to terminate this Lease upon 30 days written notice to Lessor. 

(c) Notwithstanding the above, the provisions concerning Capital Expenditures are intended to apply only to non-voluntary,
unexpected, and new Applicable Requirements. If the Capital Expenditures are instead triggered by Lessee as a result of an actual or proposed change in use, change in intensity of use, or modification to the Premises then, and in that event, Lessee
shall be fully responsible for the cost thereof, and Lessee shall not have any right to terminate this Lease. 
 2.4
Acknowledgements. Lessee acknowledges that: (a) it has been advised by Lessor and/or Brokers to satisfy itself with respect to the condition of the Premises (including but not limited to the electrical, HVAC and fire sprinkler systems,
security, environmental aspects, and compliance with Applicable Requirements and the Americans with Disabilities Act), and their suitability for Lessee’s intended use, (b) Lessee has made such investigation as it deems necessary with
reference to such matters and assumes all responsibility therefor as the same relate to its occupancy of the Premises, and (c) neither Lessor, Lessor’s agents, nor Brokers have made any oral or written representations or warranties with
respect to said matters other than as set forth in this Lease. In addition, Lessor acknowledges that: (i) Brokers have made no representations, promises or warranties concerning Lessee’s ability to honor the Lease or suitability to occupy
the Premises, and (ii) it is Lessor’s sole responsibility to investigate the financial capability and/or suitability of all proposed tenants. 

2.5 Lessee as Prior Owner/Occupant. The warranties made by Lessor in Paragraph 2 shall be of no force or effect if
immediately prior to the Start Date Lessee was the owner or occupant of the Premises. In such event, Lessee shall be responsible for any necessary corrective work. 

2.6 Vehicle Parking. Lessee shall be entitled to use the number of Unreserved Parking Spaces and Reserved Parking Spaces
specified in Paragraph 1.2(b) on those portions of the Common Areas designated from time to time by Lessor for parking. Lessee shall not use more parking spaces than said number. Said parking spaces shall be used for parking by vehicles no larger
than full-size passenger automobiles or pick-up trucks, herein called “Permitted Size Vehicles.” Lessor may regulate the loading and unloading of vehicles by adopting Rules and Regulations as provided in Paragraph 2.9. No vehicles
other than Permitted Size Vehicles may be parked in the Common Area without the prior written permission of Lessor. 
 (a)
Lessee shall not permit or allow any vehicles that belong to or are controlled by Lessee or Lessee’s employees, suppliers, shippers, customers, contractors or invitees to be loaded, unloaded, or parked in areas other than those designated by
Lessor for such activities. 
 (b) Lessee shall not service or store any vehicles in the Common Areas. 

(c) If Lessee permits or allows any of the prohibited activities described in this Paragraph 2.6, then Lessor shall have the right,
without notice, in addition to such other rights and remedies that it may have, to remove or tow away the vehicle involved and charge the cost to Lessee, which cost shall be immediately payable upon demand by Lessor. 

(d) Lessor reserves the right to designate, change, or eliminate employee parking areas in the Project. 

2.7 Common Areas - Definition. The term “Common Areas” is defined as all areas and facilities outside the
Premises and within the exterior boundary line of the Project and interior utility raceways and installations within the Unit that are provided and designated by the Lessor from time to time for the general non-exclusive use of Lessor, Lessee and
other tenants of the Project and their respective employees, suppliers, shippers, customers, contractors and invitees, including parking areas, loading and unloading areas, trash areas, roadways, walkways, driveways and landscaped areas. 

2.8 Common Areas - Lessee’s Rights. Lessor grants to Lessee, for the benefit of Lessee and its employees, suppliers,
shippers, contractors, customers and invitees, during the term of this Lease, the non-exclusive right to use, in common with others entitled to such use, the Common Areas as they exist from time to time, subject to any rights, powers, and privileges
reserved by Lessor under the terms hereof or under the terms of any rules and regulations or restrictions governing the use of the Project. Under no circumstances shall the right herein granted to use the Common Areas be deemed to include the right
to store any property, temporarily or permanently, in the Common Areas. Any such storage shall be permitted only by the prior written consent of Lessor or Lessor’s designated agent, which consent may be revoked at any time. In the event that
any unauthorized storage shall occur then Lessor shall have the right, without notice, in addition to such other rights and remedies that it may have, to remove the property and charge the cost to Lessee, which cost shall be immediately payable upon
demand by Lessor. 
 2.9 Common Areas - Rules and Regulations. Lessor or such other person(s) as Lessor may appoint
shall have the exclusive control and management of the Common Areas and shall have the right, from time to time, to establish, modify, amend and enforce reasonable rules and regulations (“Rules and Regulations”) for the management,
safety, care, and cleanliness of the grounds, the parking and unloading of vehicles and the preservation of good order, as well as for the convenience of other occupants or tenants of the Building and the Project and their invitees. Lessee agrees to
abide by and conform to all such Rules and Regulations, and to cause its employees, suppliers, shippers, customers, contractors and invitees to so abide and conform. Lessor shall not be responsible to Lessee for the non-compliance with said Rules
and Regulations by other tenants of the Project. 
 2.10 Common Areas - Changes. Lessor shall have the right, in
Lessor’s sole discretion, from time to time: 
 (a) To make changes to the Common Areas, including, without
limitation, changes in the location, size, shape and number of driveways, entrances, parking spaces, parking areas, loading and unloading areas, ingress, egress, direction of traffic, landscaped areas, walkways and utility raceways; 

(b) To close temporarily any of the Common Areas for maintenance purposes so long as reasonable access to the Premises remains
available; 
 (c) To designate other land outside the boundaries of the Project to be a part of the Common
Areas; 
 (d) To add additional buildings and improvements to the Common Areas; 

(e) To use the Common Areas while engaged in making additional improvements, repairs or alterations to the Project, or any portion
thereof; and 
 (f) To do and perform such other acts and make such other changes in, to or with respect to the Common
Areas and Project as Lessor may, in the exercise of sound business judgment, deem to be appropriate. 
 3. Term. 

3.1 Term. The Commencement Date, Expiration Date and Original Term of this Lease are as specified in Paragraph 1.3.

 3.2 Early Possession. If Lessee totally or partially occupies the Premises prior to the Commencement Date, the
obligation to pay Base Rent shall be abated for the period of such early possession. All other terms of this Lease (including but not limited to the obligations to pay Lessee’s Share of Common Area Operating Expenses, Real Property Taxes and
insurance premiums and to maintain the Premises) shall, however, be in effect during such period. Any such early possession shall not affect the Expiration Date. 

3.3 Delay In Possession. Lessor agrees to use its best commercially reasonable efforts to deliver possession of the Premises
to Lessee by 
  

									
		 		  		  		  	
	 	 		  		  		  	 
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the Commencement Date. If, despite said efforts, Lessor is unable to deliver possession as agreed, Lessor shall not be subject to any liability therefor, nor shall such failure affect the
validity of this Lease. Lessee shall not, however, be obligated to pay Rent or perform its other obligations until it receives possession of the Premises. If possession is not delivered within 60 days after the Commencement Date, Lessee may, at its
option, by notice in writing within 10 days after the end of such 60 day period, cancel this Lease, in which event the Parties shall be discharged from all obligations hereunder. If such written notice is not received by Lessor within said 10 day
period, Lessee’s right to cancel shall terminate. Except as otherwise provided, if possession is not tendered to Lessee by the Start Date and Lessee does not terminate this Lease, as aforesaid, any period of rent abatement that Lessee would
otherwise have enjoyed shall run from the date of delivery of possession and continue for a period equal to what Lessee would otherwise have enjoyed under the terms hereof, but minus any days of delay caused by the acts or omissions of Lessee. If
possession of the Premises is not delivered within 4 months after the Commencement Date, this Lease shall terminate unless other agreements are reached between Lessor and Lessee, in writing. 

3.4 Lessee Compliance. Lessor shall not be required to tender possession of the Premises to Lessee until Lessee complies
with its obligation to provide evidence of insurance (Paragraph 8.5). Pending delivery of such evidence, Lessee shall be required to perform all of its obligations under this Lease from and after the Start Date, including the payment of Rent,
notwithstanding Lessor’s election to withhold possession pending receipt of such evidence of insurance. Further, if Lessee is required to perform any other conditions prior to or concurrent with the Start Date, the Start Date shall occur but
Lessor may elect to withhold possession until such conditions are satisfied. 
 4. Rent. 

4.1 Rent Defined. All monetary obligations of Lessee to Lessor under the terms of this Lease (except for the Security
Deposit) are deemed to be rent (“Rent”). 
 4.2 Common Area Operating Expenses. Lessee shall pay
to Lessor during the term hereof, in addition to the Base Rent, Lessee’s Share (as specified in Paragraph 1.6) of all Common Area Operating Expenses, as hereinafter defined, during each calendar year of the term of this Lease, in accordance
with the following provisions: 
 (a) “Common Area Operating Expenses” are defined, for purposes of this
Lease, as all costs incurred by Lessor relating to the ownership and operation of the Project, including, but not limited to, the following: 
  

	 	 (i)
	 The operation, repair and maintenance, in neat, clean, good order and condition of the following: 

(aa) The Common Areas and Common Area improvements, including parking areas, loading and unloading areas, trash areas, roadways,
parkways, walkways, driveways, landscaped areas, bumpers, irrigation systems, Common Area lighting facilities, fences and gates, elevators, roofs, and roof drainage systems. 

(bb) Exterior signs and any tenant directories. 

(cc) Any fire detection and/or sprinkler systems. 
  

	 	 (ii)
	 The cost of water, gas, electricity and telephone to service the Common Areas and any utilities not separately metered. 

 

	 	 (iii)
	 Trash disposal, pest control services, property management, security services, and the costs of any environmental inspections. 

 

	 	 (iv)
	 Reserves set aside for maintenance and repair of Common Areas. 

 

	 	 (v)
	 Real Property Taxes (as defined in Paragraph 10). 

  

	 	 (vi)
	 The cost of the premiums for the insurance maintained by Lessor pursuant to Paragraph 8. 

 

	 	 (vii)
	 Any deductible portion of an insured loss concerning the Building or the Common Areas. 

 

	 	 (viii)
	 The cost of any Capital Expenditure to the Building or the Project not covered under the provisions of Paragraph 2.3 provided; however, that Lessor shall
allocate the cost of any such Capital Expenditure over a 12 year period and Lessee shall not be required to pay more than Lessee’s Share of 1/144th of the cost of such Capital Expenditure in any given month. 

 

	 	 (ix)
	 Any other services to be provided by Lessor that are stated elsewhere in this Lease to be a Common Area Operating Expense. 

(b) Any Common Area Operating Expenses and Real Property Taxes that are specifically attributable to the Unit (which shall
specifically include the tax assessment of the existing improvements, and any new improvements to the suite), the Building or to any other building in the Project or to the operation, repair and maintenance thereof, shall be allocated entirely to
such Unit, Building, or other building. However, any Common Area Operating Expenses and Real Property Taxes that are not specifically attributable to the Building or to any other building or to the operation, repair and maintenance thereof, shall be
equitably allocated by Lessor to all buildings in the Project. 
 (c) The inclusion of the improvements, facilities and
services set forth in Subparagraph 4.2(a) shall not be deemed to impose an obligation upon Lessor to either have said improvements or facilities or to provide those services unless the Project already has the same, Lessor already provides the
services, or Lessor has agreed elsewhere in this Lease to provide the same or some of them. 
 (d) Lessee’s
Share of Common Area Operating Expenses shall be payable by Lessee within 10 days after a reasonably detailed statement of actual expenses is presented to Lessee. At Lessor’s option, however, an An amount may be estimated by Lessor
from time to time of Lessee’s Share of annual Common Area Operating Expenses and the same shall be payable monthly or quarterly, as Lessor shall designate, during each 12 month period of the Lease term, on the same day as the
Base Rent is due hereunder. Lessor shall deliver to Lessee within 60 days after the expiration of each calendar year a reasonably detailed statement showing Lessee’s Share of the actual Common Area Operating Expenses incurred during the
preceding year. If Lessee’s payments under this Paragraph 4.2(d) during the preceding year exceed Lessee’s Share as indicated on such statement; Lessor shall credit the amount of such over-payment against Lessee’s Share of Common Area
Operating Expenses next becoming due. If Lessee’s payments under this Paragraph 4.2(d) during the preceding year were less than Lessee’s Share as indicated on such statement, Lessee shall pay to Lessor the amount of the deficiency within
10 days after delivery by Lessor to Lessee of the statement. 
 (e) Exclusions to Common Area Operating Expenses: The
“Common Area Operating Expenses” shall exclude the following: 
  

	 	 (i)
	 depreciation, interest and/or amortization on mortgages or ground lease payments; 

 

	 	 (ii)
	 legal fees incurred in negotiating and enforcing other tenant leases affecting the Project; 

 

	 	 (iii)
	 real estate broker commissions; 

  

	 	 (iv)
	 initial improvements or alterations to tenant spaces; 

  

	 	 (v)
	 the cost of providing any service directly to, and paid directly by, any other tenant; 

 

	 	 (vi)
	 Cost of any items for which Lessor receives reimbursement from insurance proceeds or from any third party (other than reimbursement from the other tenants of
the Building based upon such tenants’ pro rata share of Common Area Operating Expenses); 

  

	 	 (vii)
	 costs and expenses incurred with respect to the removal of Hazardous Substances not attributable to the acts of Lessee; 

 

	 	 (viii)
	 any management fee in excess of four percent (4%) of the Base Rent; and 

 

	 	 (ix)
	 any federal and state income taxes, and other taxes applied or measured by Lessor’s general or net income (as opposed to rents, receipts; or income
directly attributable to operation of the Project and excluding real property taxes and assessments which are Lessee’s responsibility under the lease). 

4.3 Payment. Lessee shall cause payment of Rent to be received by Lessor in lawful money of the United States, without
offset or deduction (except as specifically permitted in this Lease), on or before the day on which it is due. Rent for any period during the term hereof which is for less than one full calendar month shall be prorated based upon the actual number
of days of said month. Payment of Rent shall be made to Lessor at its address stated herein or to such other persons or place as Lessor may from time to time designate in writing. Acceptance of a payment which is less than the amount then due shall
not be a waiver of Lessor’s rights to the balance of such Rent, regardless of Lessor’s endorsement of any check so stating. In the event that any check, draft, or other instrument of payment given by Lessee to Lessor is dishonored for any
reason, Lessee agrees to pay to Lessor the sum of $25 in addition to any late charges which may be due. 
 5. Security Deposit.
Lessee shall deposit with Lessor upon execution hereof the Security Deposit as security for Lessee’s faithful performance of its obligations under this Lease. If Lessee fails to pay Rent, or otherwise Defaults under this Lease, Lessor may use,
apply or retain all or any portion of said Security Deposit for the payment of any amount due Lessor or to reimburse or compensate Lessor for any liability, expense, loss or damage which Lessor may suffer or incur by reason thereof. If Lessor uses
or applies all or any portion of the Security Deposit, Lessee shall within 10 days after written request therefor deposit monies with Lessor sufficient to restore said Security Deposit to the full amount required by this Lease. If the Base Rent
increases during the 
  

									
		 		  		  		  	
	 	 		  		  		  	 
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term of this Lease, Lessee shall, upon written request from Lessor, deposit additional monies with Lessor so that the total amount of the Security Deposit shall at all times bear the same
proportion to the increased Base Rent as the initial Security Deposit bore to the initial Base Rent. Should the Agreed Use be amended to accommodate a material change in the business of Lessee or to accommodate a sublessee or assignee, Lessor shall
have the right to increase the Security Deposit to the extent necessary, in Lessor’s reasonable judgment, to account for any increased wear and tear that the Premises may suffer as a result thereof. If a change in control of Lessee occurs
during this Lease and following such change the financial condition of Lessee is, in Lessor’s reasonable judgment, significantly reduced, Lessee shall deposit such additional monies with Lessor as shall be sufficient to cause the Security
Deposit to be at a commercially reasonable level based on such change in financial condition. Lessor shall not be required to keep the Security Deposit separate from its general accounts. Within 14 days after the expiration or termination of this
Lease, if Lessor elects to apply the Security Deposit only to unpaid Rent, and otherwise within 30 days after the Premises have been vacated pursuant to Paragraph 7.4(c) below, Lessor shall return that portion of the Security Deposit not used or
applied by Lessor. No part of the Security Deposit shall be considered to be held in trust, to bear interest or to be prepayment for any monies to be paid by Lessee under this Lease. If Lessee Defaults under any of the terms of this lease; the
Security Deposit shall be increased to an amount equal to three month of the then current Base Rent and NNN charges. 
 6. Use.

 6.1 Use. Lessee shall use and occupy the Premises only for the Agreed Use, or any other legal use which is
reasonably comparable thereto, and for no other purpose. Lessee shall not use or permit the use of the Premises in a manner that is unlawful, creates damage, waste or a nuisance, or that disturbs occupants of or causes damage to neighboring premises
or properties. Lessor shall not unreasonably withhold or delay its consent to any written request for a modification of the Agreed Use, so long as the same will not impair the structural integrity of the improvements on the Premises or the
mechanical or electrical systems therein, and/or is not significantly more burdensome to the Premises. If Lessor elects to withhold consent, Lessor shall within 7 days after such request give written notification of same, which notice shall include
an explanation of Lessor’s objections to the change in the Agreed Use. 
 6.2 Hazardous Substances.

 (a) Reportable Uses Require Consent. The term “Hazardous Substance” as used in this Lease shall
mean any product, substance, or waste whose presence, use, manufacture, disposal, transportation, or release, either by itself or in combination with other materials expected to be on the Premises, is either: (i) potentially injurious to the
public health, safety or welfare, the environment or the Premises, (ii) regulated or monitored by any governmental authority, or (iii) a basis for potential liability of Lessor to any governmental agency or third party under any applicable
statute or common law theory. Hazardous Substances shall include, but not be limited to, hydrocarbons, petroleum, gasoline, and/or crude oil or any products, by-products or fractions thereof. Lessee shall not engage in any activity in or on the
Premises which constitutes a Reportable Use of Hazardous Substances without the express prior written consent of Lessor and timely compliance (at Lessee’s expense) with all Applicable Requirements. "Reportable Use" shall mean (i) the
installation or use of any above or below ground storage tank, (ii) the generation, possession, storage, use, transportation, or disposal of a Hazardous Substance that requires a permit from, or with respect to which a report, notice,
registration or business plan is required to be filed with, any governmental authority, and/or (iii) the presence at the Premises of a Hazardous Substance with respect to which any Applicable Requirements requires that a notice be given to
persons entering or occupying the Premises or neighboring properties. Notwithstanding the foregoing, Lessee may use any ordinary and customary materials reasonably required to be used in the normal course of the Agreed Use, so long as such use is in
compliance with all Applicable Requirements, is not a Reportable Use, and does not expose the Premises or neighboring property to any meaningful risk of contamination or damage or expose Lessor to any liability therefor. In addition, Lessor may
condition its consent to any Reportable Use upon receiving such additional assurances as Lessor reasonably deems necessary to protect itself, the public, the Premises and/or the environment against damage, contamination, injury and/or liability,
including, but not limited to, the installation (and removal on or before Lease expiration or termination) of protective modifications (such as concrete encasements) and/or increasing the Security Deposit. Lessee may use amounts and types of
Hazardous Substances which are reasonable and customary for purposes of conducting its business operations in accordance with its Permitted Use of the Premises in accordance with Applicable Requirements and/or Law. 

(b) Duty to Inform Lessor. If Lessee knows, or has reasonable cause to believe, that a Hazardous Substance has come to be
located in, on, under or about the Premises, other than as previously consented to by Lessor, or in violation of Applicable Requirements, and/or Law, Lessee shall immediately give written notice of such fact to Lessor, and provide Lessor with a copy
of any report, notice, claim or other documentation which it has concerning the presence of such Hazardous Substance. 

                (c) Lessee Remediation. Lessee shall not
cause or permit any Hazardous Substance to be spilled or released in, on, under, or about the Premises (including through the plumbing or sanitary sewer system) and shall promptly, at Lessee’s expense, take all investigatory and/or remedial
action reasonably recommended, whether or not formally ordered or required, for the cleanup of any contamination of, and for the maintenance, security and/or monitoring of the Premises or neighboring properties, that was caused or materially
contributed to by Lessee, or pertaining to or involving any Hazardous Substance brought onto the Premises during the term of this Lease, by or for Lessee, or any third party. 

(d) Lessee Indemnification. Lessee shall indemnify, defend and hold Lessor, its agents, employees, lenders and ground
lessor, if any, harmless from and against any and all loss of rents and/or damages, liabilities, judgments, claims, expenses, penalties, and attorneys’ and consultants’ fees arising out of or involving any Hazardous Substance brought onto
the Premises by or for Lessee, or any third party (provided, however, that Lessee shall have no liability under this Lease with respect to underground migration of any Hazardous Substance under the Premises from areas outside of the Project).
Lessee’s obligations shall include, but not be limited to, the effects of any contamination or injury to person, property or the environment created or suffered by Lessee, and the cost of investigation, removal, remediation, restoration and/or
abatement, and shall survive the expiration or termination of this Lease. No termination, cancellation or release agreement entered into by Lessor and Lessee shall release Lessee from its obligations under this Lease with respect to Hazardous
Substances, unless specifically so agreed by Lessor in writing at the time of such agreement. 
 (e) Lessor
Indemnification. Lessor and its successors and assigns shall indemnify, defend, reimburse and hold Lessee, its employees and lenders, harmless from and against any and all environmental damages, including the cost of remediation, which existed
as a result of Hazardous Substances on the Premises prior to the Start Date or which are caused by the gross negligence or willful misconduct of Lessor, its agents or employees. Lessor’s obligations, as and when required by the Applicable
Requirements, shall include, but not be limited to, the cost of investigation, removal, remediation, restoration and/or abatement, and shall survive the expiration or termination of this Lease. 

(f) Investigations and Remediations. Lessor shall retain the responsibility and pay for any investigations or remediation
measures required by governmental entities having jurisdiction with respect to the existence of Hazardous Substances on the Premises prior to the Start Date, unless such remediation measure is required as a result of Lessee’s use (including
“Alterations”, as defined in paragraph 7.3(a) below) of the Premises, in which event Lessee shall be responsible for such payment. Lessee shall cooperate fully in any such activities at the request of Lessor, including allowing Lessor and
Lessor’s agents to have reasonable access to the Premises at reasonable times in order to carry out Lessor’s investigative and remedial responsibilities. 

(g) Lessor Termination Option. If a Hazardous Substance Condition (see Paragraph 9.1(e)) occurs during the term of this
Lease, unless Lessee is legally responsible therefor (in which case Lessee shall make the investigation and remediation thereof required by the Applicable Requirements and this Lease shall continue in full force and effect, but subject to
Lessor’s rights under Paragraph 6.2(d) and Paragraph 13), Lessor may, at Lessor’s option, either (i) investigate and remediate such Hazardous Substance Condition, if required, as soon as reasonably possible at Lessor’s expense,
in which event this Lease shall continue in full force and effect, or (ii) if the estimated cost to remediate such condition exceeds 12 times the then monthly Base Rent or $100,000, whichever is greater, give written notice to Lessee, within 30
days after receipt by Lessor of knowledge of the occurrence of such Hazardous Substance Condition, of Lessor’s desire to terminate this Lease as of the date 60 days following the date of such notice. In the event Lessor elects to give a
termination notice, Lessee may, within 10 days thereafter, give written notice to Lessor of Lessee’s commitment to pay the amount by which the cost of the remediation of such Hazardous Substance Condition exceeds an amount equal to 12 times the
then monthly Base Rent or $100,000, whichever is greater. Lessee shall provide Lessor with said funds or satisfactory assurance thereof within 30 days following such commitment. In such event, this Lease shall continue in full force and effect, and
Lessor shall proceed to make such remediation as soon as reasonably possible after the required funds are available. If Lessee does not give such notice and provide the required funds or assurance thereof within the time provided, this Lease shall
terminate as of the date specified in Lessor’s notice of termination. 
 6.3 Lessee’s Compliance with
Applicable Requirements. Except as otherwise provided in this Lease, Lessee shall, at Lessee’s sole expense, fully, diligently and in a timely manner, materially comply with all Applicable Requirements, the requirements of any applicable
fire insurance underwriter or rating bureau, and the recommendations of Lessor’s engineers and/or consultants which relate in any manner to the Premises, without regard to whether said requirements are now in effect or become effective after
the Start Date. Lessee shall, within 10 days after receipt of Lessor’s written request, provide Lessor with copies of all permits and other documents, and other information evidencing Lessee’s compliance with any Applicable Requirements
specified by Lessor, and shall immediately upon receipt, notify Lessor in writing (with copies of any documents involved) of any threatened or actual claim, notice, citation, warning, complaint or report pertaining to or involving the failure of
Lessee or the Premises to comply with any Applicable Requirements. 
         6.4 Inspection;
Compliance. Lessor and Lessor’s “Lender” (as defined in Paragraph 30) and consultants shall have the right to enter into Premises at any time, in the case of an emergency, and otherwise at reasonable times, for the purpose
of inspecting the condition of the Premises and for verifying compliance by Lessee with this Lease. The cost of any such inspections shall be paid by Lessor, unless a violation of Applicable Requirements, or a contamination is found to exist or be
imminent, or the inspection is requested or ordered by a governmental authority. In such case, Lessee shall upon request reimburse Lessor for the cost of such inspection, so long as such inspection is reasonably related to the violation or
contamination. 
 7. Maintenance; Repairs, Utility Installations; Trade Fixtures and Alterations. 

 

									
		 		  		  		  	
	 	 		  		  		  	 
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 7.1 Lessee’s Obligations. 

(a) In General. Subject to the provisions of Paragraph 2.2 (Condition), 2.3 (Compliance), 6.3 (Lessee’s Compliance with
Applicable Requirements), 7.2 (Lessor’s Obligations), 9 (Damage or Destruction), and 14 (Condemnation), Lessee shall, at Lessee’s sole expense, keep the Premises, Utility Installations (intended for Lessee’s exclusive use, no matter
where located), and Alterations in good order, condition and repair (whether or not the portion of the Premises requiring repairs, or the means of repairing the same, are reasonably or readily accessible to Lessee, and whether or not the need for
such repairs occurs as a result of Lessee’s use, any prior use, the elements or the age of such portion of the Premises), including, but not limited to, all equipment or facilities, such as plumbing, HVAC equipment, electrical, lighting
facilities, boilers, pressure vessels, fixtures, interior walls, interior surfaces of exterior walls, ceilings, floors, windows, doors, plate glass, and skylights but excluding any items which are the responsibility of Lessor pursuant to Paragraph
7.2. Lessee, in keeping the Premises in good order, condition and repair, shall exercise and perform good maintenance practices, specifically including the procurement and maintenance of the service contracts required by Paragraph 7.1(b) below.
Lessee’s obligations shall include restorations, replacements or renewals when necessary to keep the Premises and all improvements thereon or a part thereof in good order, condition and state of repair. 

(b) Service Contracts. Lessee shall, at Lessee’s sole expense, procure and maintain contracts, with copies to Lessor,
in customary form and substance for, and with contractors specializing and experienced in the maintenance of the following equipment and improvements, if any, if and when installed on the Premises: (i) HVAC equipment, (ii) boiler and
pressure vessels, (iii) clarifiers, and (iv) any other equipment, if reasonably required by Lessor. However, Lessor reserves the right, upon notice to Lessee, to procure and maintain any or all of such service contracts, and if Lessor so
elects, Lessee shall reimburse Lessor, upon demand, for the cost thereof. 
 (c) Failure to Perform. If Lessee
fails to perform Lessee’s obligations under this Paragraph 7.1, Lessor may enter upon the Premises after 10 days’ prior written notice to Lessee (except in the case of an emergency, in which case no notice shall be required), perform such
obligations on Lessee’s behalf, and put the Premises in good order, condition and repair, and Lessee shall promptly reimburse Lessor for the cost thereof. 

(d) Replacement. Subject to Lessee’s indemnification of Lessor as set forth in Paragraph 8.7 below, and without
relieving Lessee of liability resulting from Lessee’s failure to exercise and perform good maintenance practices, if an item described in Paragraph 7.1(b) cannot be repaired other than at a cost which is in excess of 50% of the cost of
replacing such item, then such item shall be replaced by Lessor, and the cost thereof shall be prorated between the Parties and Lessee shall only be obligated to pay, each month during the remainder of the term of this Lease, on the date on which
Base Rent is due, an amount equal to the product of multiplying the cost of such replacement by a fraction, the numerator of which is one, and the denominator of which is 144 (ie. 1/144th of the cost per month). Lessee shall pay Interest on the
unamortized balance at a rate that is commercially reasonable in the judgment of Lessor’s accountants. Lessee may, however, prepay its obligation at any time. 

7.2 Lessor’s Obligations. Subject to the provisions of Paragraphs 2.2 (Condition), 2.3 (Compliance), 4.2 (Common Area
Operating Expenses), 6 (Use), 7.1 (Lessee’s Obligations), 9 (Damage or Destruction) and 14 (Condemnation), Lessor, subject to reimbursement pursuant to Paragraph 4.2, shall keep in good order, condition and repair the foundations, exterior
walls, structural condition of interior bearing walls, exterior roof, fire sprinkler system, Common Area fire alarm and/or smoke detection systems, fire hydrants, parking lots, walkways, parkways, driveways, landscaping, fences, signs and utility
systems serving the Common Areas and all parts thereof, as well as providing the services for which there is a Common Area Operating Expense pursuant to Paragraph 4.2. Lessor shall not be obligated to paint the exterior or interior surfaces of
exterior walls nor shall Lessor be obligated to maintain, repair or replace windows, doors or plate glass of the Premises. Lessee expressly waives the benefit of any statute now or hereafter in effect to the extent it is inconsistent with the terms
of this Lease. 
 7.3 Utility Installations; Trade Fixtures; Alterations. 

(a) Definitions. The term “Utility Installations” refers to all floor and window coverings, air lines,
power panels, electrical distribution, security and fire protection systems, communication systems, lighting fixtures, HVAC equipment, plumbing, and fencing in or on the Premises. The term “Trade Fixtures” shall mean Lessee’s
machinery and equipment that can be removed without doing material damage to the Premises. The term “Alterations” shall mean any modification of the improvements, other than Utility Installations or Trade Fixtures, whether by
addition or deletion. “Lessee Owned Alterations and/or Utility Installations” are defined as Alterations and/or Utility Installations made by Lessee that are not yet owned by Lessor pursuant to Paragraph 7.4(a). 

                (b) Consent. Lessee shall not make any
Alterations or Utility Installations to the Premises without Lessor’s prior written consent. Lessee may, however, make non-structural Utility Installations to the interior of the Premises (excluding the roof) without such consent but upon
notice to Lessor, as long as they are not visible from the outside, do not involve puncturing, relocating or removing the roof or any existing walls, and the cumulative cost thereof during this Lease as extended does not exceed a sum equal to 3
month’s Base Rent in the aggregate or a sum equal to one month’s Base Rent in any one year. Notwithstanding the foregoing, Lessee shall not make or permit any roof penetrations and/or install anything on the roof without the prior written
approval of Lessor. Lessor may, as a precondition to granting such approval, require Lessee to utilize a contractor chosen and/or approved by Lessor. Any Alterations or Utility Installations that Lessee shall desire to make and which require the
consent of the Lessor shall be presented to Lessor in written form with detailed plans. Consent shall be deemed conditioned upon Lessee’s: (i) acquiring all applicable governmental permits, (ii) furnishing Lessor with copies of both
the permits and the plans and specifications prior to commencement of the work, and (iii) compliance with all conditions of said permits and other Applicable Requirements in a prompt and expeditious manner. Any Alterations or Utility
Installations shall be performed in a workmanlike manner with good and sufficient materials. Lessee shall promptly upon completion furnish Lessor with as-built plans and specifications. For work which costs an amount in excess of one month’s
Base Rent, Lessor may condition its consent upon Lessee providing a lien and completion bond in an amount equal to 150% of the estimated cost of such Alteration or Utility Installation and/or upon Lessee’s posting an additional Security Deposit
with Lessor. 
 (c) Indemnification. Lessee shall pay, when due, all claims for labor or materials furnished or
alleged to have been furnished to or for Lessee at or for use on the Premises, which claims are or may be secured by any mechanic’s or materialman’s lien against the Premises or any interest therein. Lessee shall give Lessor not less than
10 days notice prior to the commencement of any work in, on or about the Premises, and Lessor shall have the right to post notices of non-responsibility. If Lessee shall contest the validity of any such lien, claim or demand, then Lessee shall, at
its sole expense defend and protect itself, Lessor and the Premises against the same and shall pay and satisfy any such adverse judgment that may be rendered thereon before the enforcement thereof. If Lessor shall require, Lessee shall furnish a
surety bond in an amount equal to 150% of the amount of such contested lien, claim or demand, indemnifying Lessor against liability for the same. If Lessor elects to participate in any such action, Lessee shall pay Lessor’s attorneys’ fees
and costs. 
 7.4 Ownership; Removal; Surrender; and Restoration. 

(a) Ownership. Subject to Lessor’s right to require removal or elect ownership as hereinafter provided, all Alterations
and Utility Installations made by Lessee shall be the property of Lessee, but considered a part of the Premises. Lessor may, at any time, elect in writing to be the owner of all or any specified part of the Lessee Owned Alterations and Utility
Installations. Unless otherwise instructed per paragraph 7.4(b) hereof, all Lessee Owned Alterations and Utility Installations shall, at the expiration or termination of this Lease, become the property of Lessor and be surrendered by Lessee with the
Premises. 
 (b) Removal. By delivery to Lessee of written notice from Lessor not earlier than 90 and not later
than 30 days prior to the end of the term of this Lease, Lessor may require that any or all Lessee Owned Alterations or Utility Installations be removed by the expiration or termination of this Lease. Lessor may require the removal at any time of
all or any part of any Lessee Owned Alterations or Utility Installations made without the required consent. 
 (c)
Surrender; Restoration. Lessee shall surrender the Premises by the Expiration Date or any earlier termination date, with all of the improvements, parts and surfaces thereof broom clean and free of debris, and in good operating order,
condition and state of repair, ordinary wear and tear excepted. “Ordinary wear and tear” shall not include any damage or deterioration that would have been prevented by good maintenance practice. Notwithstanding the foregoing, if this
Lease is for 12 months or less, then Lessee shall surrender the Premises in the same condition as delivered to Lessee on the Start Date with NO allowance for ordinary wear and tear. Lessee shall repair any damage occasioned by the installation,
maintenance or removal of Trade Fixtures, Lessee owned Alterations and/or Utility Installations, furnishings, and equipment as well as the removal of any storage tank installed by or for Lessee. Lessee shall also completely remove from the Premises
any and all Hazardous Substances brought onto the Premises by or for Lessee, or any third party (except Hazardous Substances which were deposited via underground migration from areas outside of the Project) even if such removal would require Lessee
to perform or pay for work that exceeds statutory requirements. Trade Fixtures shall remain the property of Lessee and shall be removed by Lessee. The failure by Lessee to timely vacate the Premises pursuant to this Paragraph 7.4(c) without the
express written consent of Lessor shall constitute a holdover under the provisions of Paragraph 26 below. 
 8. Insurance;
Indemnity. 
 8.1 Payment of Premiums. The cost of the premiums for the insurance policies required to be
carried by Lessor, pursuant to Paragraphs 8.2(b), 8.3(a) and 8.3(b), shall be a Common Area Operating Expense. Premiums for policy periods commencing prior to, or extending beyond, the term of this Lease shall be prorated to coincide with the
corresponding Start Date or Expiration Date. 
 8.2 Liability Insurance. 

(a) Carried by Lessee. Lessee shall obtain and keep in force a Commercial General Liability policy of insurance protecting
Lessee and Lessor as an additional insured against claims for bodily injury, personal injury and property damage based upon or arising out of the ownership, use, occupancy or maintenance of the Premises and all areas appurtenant thereto. Such
insurance shall be on an occurrence basis providing single limit coverage in an amount not less than $1,000,000 per occurrence with an annual aggregate of not less than $2,000,000, an “Additional Insured-Managers or Lessor’s of Premises
Endorsement” and contain the “Amendment of the Pollution Exclusion Endorsement” and coverage shall also be extended to include damage caused by heat, smoke or fumes from a hostile fire. The policy shall not contain any intra-insured
exclusions as between insured persons or organizations, but shall include coverage for liability assumed under this Lease as an “insured contract” for the performance of Lessee’s indemnity obligations under this Lease. The limits of
said insurance shall not, however, limit the liability of Lessee nor relieve Lessee of any obligation hereunder. All insurance carried by Lessee shall be primary to and not contributory with any similar insurance carried by Lessor, whose insurance
shall be considered excess insurance only. 
  

									
		 		  		  		  	
	 	 		  		  		  	 
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 (b) Carried by Lessor. Lessor shall maintain liability insurance as described
in Paragraph 8.2(a), in addition to, and not in lieu of, the insurance required to be maintained by Lessee. Lessee shall not be named as an additional insured therein. 

8.3 Property Insurance - Building, Improvements and Rental Value. 

(a) Building and Improvements. Lessor shall obtain and keep in force a policy or policies of insurance in the name of
Lessor, with loss payable to Lessor, any ground-lessor, and to any Lender insuring loss or damage to the Premises. The amount of such insurance shall be equal to the full replacement cost of the Premises, as the same shall exist from time to time,
or the amount required by any Lender, but in no event more than the commercially reasonable and available insurable value thereof. Lessee Owned Alterations and Utility Installations, Trade Fixtures, and Lessee’s personal property shall be
insured by Lessee under Paragraph 8.4. If the coverage is available and commercially appropriate, such policy or policies shall insure against all risks of direct physical loss or damage (except the perils of flood and/or earthquake unless required
by a Lender), including coverage for debris removal and the enforcement of any Applicable Requirements requiring the upgrading, demolition, reconstruction or replacement of any portion of the Premises as the result of a covered loss. Said policy or
policies shall also contain an agreed valuation provision in lieu of any coinsurance clause, waiver of subrogation, and inflation guard protection causing an increase in the annual property insurance coverage amount by a factor of not less than the
adjusted U.S. Department of Labor Consumer Price Index for All Urban Consumers for the city nearest to where the Premises are located. If such insurance coverage has a deductible clause, the deductible amount shall not exceed $1,000 per occurrence.

 (b) Rental Value. Lessor shall also obtain and keep in force a policy or policies in the name of Lessor with
loss payable to Lessor and any Lender, insuring the loss of the full Rent for one year with an extended period of indemnity for an additional 180 days (“Rental Value Insurance”). Said insurance shall contain an agreed
valuation provision in lieu of any coinsurance clause, and the amount of coverage shall be adjusted annually to reflect the projected Rent otherwise payable by Lessee, for the next 12 month period. 

(c) Adjacent Premises. Lessee shall pay for any increase in the premiums for the property insurance of the Building and for
the Common Areas or other buildings in the Project if said increase is caused by Lessee’s acts, omissions, use or occupancy of the Premises. 

(d) Lessee’s Improvements. Since Lessor is the Insuring Party, Lessor shall not be required to insure Lessee Owned
Alterations and Utility Installations unless the item in question has become the property of Lessor under the terms of this Lease. 

8.4 Lessee’s Property; Business Interruption Insurance. 

(a) Property Damage. Lessee shall obtain and maintain insurance coverage on all of Lessee’s personal property, Trade
Fixtures, and Lessee Owned Alterations and Utility Installations. Such insurance shall be full replacement cost coverage with a deductible of not to exceed $1,000 per occurrence. The proceeds from any such insurance shall be used by Lessee for the
replacement of personal property, Trade Fixtures and Lessee Owned Alterations and Utility Installations. Lessee shall provide Lessor with written evidence that such insurance is in force. 

(b) Business Interruption. Lessee shall obtain and maintain loss of income and extra expense insurance in amounts as
will reimburse Lessee for direct or indirect loss of earnings attributable to all perils commonly insured against by prudent lessees in the business of Lessee or attributable to prevention of access to the Premises as a result of such perils.
See paragraph 8.8 and 65. 
 (c) No Representation of Adequate Coverage. Lessor makes no representation
that the limits or forms of coverage of insurance specified herein are adequate to cover Lessee’s property, business operations or obligations under this Lease. 

        8.5 Insurance Policies. Insurance required herein shall be by companies duly licensed or
admitted to transact business in the state where the Premises are located, and maintaining during the policy term a “General Policyholders Rating” of at least B+, V, as set forth in the most current issue of “Best’s Insurance
Guide”, or such other rating as may be required by a Lender. Lessee shall not do or permit to be done anything which invalidates the required insurance policies. Lessee shall, prior to the Start Date, deliver to Lessor certified copies of
policies of such insurance or certificates evidencing the existence and amounts of the required insurance. No such policy shall be cancelable or subject to modification except after 30 days prior written notice to Lessor. Lessee shall, at least 30
days prior to the expiration of such policies, furnish Lessor with evidence of renewals or “insurance binders” evidencing renewal thereof, or Lessor may order such insurance and charge the cost thereof to Lessee, which amount shall be
payable by Lessee to Lessor upon demand. Such policies shall be for a term of at least one year, or the length of the remaining term of this Lease, whichever is less. If either Party shall fail to procure and maintain the insurance required to be
carried by it, the other Party may, but shall not be required to, procure and maintain the same. 
 8.6 Waiver of
Subrogation. Without affecting any other rights or remedies, Lessee and Lessor each hereby release and relieve the other, and waive their entire right to recover damages against the other, for loss of or damage to its property arising out of or
incident to the perils required to be insured against herein. The effect of such releases and waivers is not limited by the amount of insurance carried or required, or by any deductibles applicable hereto. The Parties agree to have their respective
property damage insurance carriers waive any right to subrogation that such companies may have against Lessor or Lessee, as the case may be, so long as the insurance is not invalidated thereby. 

8.7 Indemnity. Except for Lessor’s gross negligence or willful misconduct, Lessee shall indemnify, protect, defend and
hold harmless the Premises, Lessor and its agents, Lessor’s master or ground lessor, partners and Lenders, from and against any and all claims, loss of rents and/or damages, liens, judgments, penalties, attorneys’ and consultants’
fees, expenses and/or liabilities arising out of, involving, or in connection with, the use and/or occupancy of the Premises by Lessee. If any action or proceeding is brought against Lessor by reason of any of the foregoing matters, Lessee shall
upon notice defend the same at Lessee’s expense by counsel reasonably satisfactory to Lessor and Lessor shall cooperate with Lessee in such defense. Lessor need not have first paid any such claim in order to be defended or indemnified.

 8.8 Exemption of Lessor from Liability. Lessor shall not be liable for injury or damage to the person or goods,
wares, merchandise or other property of Lessee, Lessee’s employees, contractors, invitees, customers, or any other person in or about the Premises, whether such damage or injury is caused by or results from fire, steam, electricity, gas, water
or rain, or from the breakage, leakage, obstruction or other defects of pipes, fire sprinklers, wires, appliances, plumbing, HVAC or lighting fixtures, or from any other cause, whether the said injury or damage results from conditions arising upon
the Premises or upon other portions of the Building, or from other sources or places. Lessor shall not be liable for any damages arising from any act or neglect of any other tenant of Lessor nor from the failure of Lessor to enforce the provisions
of any other lease in the Project. Notwithstanding Lessor’s negligence or breach of this Lease, Lessor shall under no circumstances be liable for injury to Lessee’s business or for any loss of income or profit therefrom. 

8.9 Payment of Deductible Amounts. Lessee’s obligation with respect to payment of any “deductible amount”
under Lessor’s liability, fire and/or casualty policies of insurance shall be as follows: 
 (a) If the damage or
destruction is caused by a negligent or intentional act or omission by Lessee or Lessee’s agents, employees or contractors or otherwise arises out of the operation of the Lessee’s business and/or occupancy of the Premises; then Lessee
shall pay the full ‘deductible amount’. 
 (b) If the damage or destruction is caused by a negligent or
intentional act or omission by another tenant of the Building or such other tenant’s agents, employees or contractors or otherwise arises out of the operation of such other tenant’s business and/or such other tenant’s occupancy of
another portion of the Building; then such other tenant shall pay the full “deductible amount” and Lessee shall have no responsibility or liability therefore and such amount shall not be included as an element of Common Area Operating
Expenses. 
 (c) If the damage or destruction arises from any other cause other than a cause described in either of the
preceding subparagraphs (a) or (b); then the “deductible amount” shall be an item of Common Area Operating Expenses. 
 9.
Damage or Destruction. 
 9.1 Definitions. 

(a) “Premises Partial Damage” shall mean damage or destruction to the improvements on the Premises, other than
Lessee Owned Alterations and Utility Installations, which can reasonably be repaired in 3 months or less from the date of the damage or destruction, and the cost thereof does not exceed a sum equal to 6 month’s Base Rent. Lessor shall notify
Lessee in writing within 30 days from the date of the damage or destruction as to whether or not the damage is Partial or Total 

(b) “Premises Total Destruction” shall mean damage or destruction to the improvements on the Premises, other than
Lessee Owned Alterations and Utility Installations and Trade Fixtures, which cannot reasonably be repaired in 3 months or less from the date of the damage or destruction and/or the cost thereof exceeds a sum equal to 6 month’s Base Rent. Lessor
shall notify Lessee in writing within 30 days from the date of the damage or destruction as to whether or not the damage is Partial or Total. 

                (c) “Insured Loss” shall mean
damage or destruction to improvements on the Premises, other than Lessee Owned Alterations and Utility Installations and Trade Fixtures, which was caused by an event required to be covered by the insurance described in Paragraph 8.3(a), irrespective
of any deductible amounts or coverage limits involved. 
 (d) “Replacement Cost” shall mean the cost to
repair or rebuild the improvements owned by Lessor at the time of the occurrence to their condition existing immediately prior thereto, including demolition, debris removal and upgrading required by the operation of Applicable Requirements, and
without deduction for depreciation. 
 (e) “Hazardous Substance Condition” shall mean the occurrence or
discovery of a condition involving the presence of, or a contamination by, a Hazardous Substance as defined in Paragraph 6.2(a), in, on, or under the Premises. 

        9.2 Partial Damage - Insured Loss. If a Premises Partial Damage that is an Insured Loss
occurs, then Lessor shall, at Lessor’s expense, repair such damage (but not Lessee’s Trade Fixtures or Lessee Owned Alterations and Utility Installations) as soon as reasonably possible and this Lease

  

									
		 		  		  		  	
	 	 		  		  		  	 
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 shall continue in full force and effect; provided, however, that Lessee shall, at Lessor’s
election, make the repair of any damage or destruction the total cost to repair of which is $5,000 or less, and, in such event, Lessor shall make any applicable insurance proceeds available to Lessee on a reasonable basis for that purpose.
Notwithstanding the foregoing, if the required insurance was not in force or the insurance proceeds are not sufficient to effect such repair, the Insuring Party shall promptly contribute the shortage in proceeds as and when required to complete said
repairs. In the event, however, such shortage was due to the fact that, by reason of the unique nature of the improvements, full replacement cost insurance coverage was not commercially reasonable and available, Lessor shall have no obligation to
pay for the shortage in insurance proceeds or to fully restore the unique aspects of the Premises unless Lessee provides Lessor with the funds to cover same, or adequate assurance thereof, within 10 days following receipt of written notice of such
shortage and request therefor. If Lessor receives said funds or adequate assurance thereof within said 10 day period, the party responsible for making the repairs shall complete them as soon as reasonably possible and this Lease shall remain in full
force and effect. If such funds or assurance are not received, Lessor may nevertheless elect by written notice to Lessee within 10 days thereafter to: (i) make such restoration and repair as is commercially reasonable with Lessor paying any
shortage in proceeds, in which case this Lease shall remain in full force and effect, or (ii) have this Lease terminate 30 days thereafter. Lessee shall not be entitled to reimbursement of any funds contributed by Lessee to repair any such
damage or destruction. Premises Partial Damage due to flood or earthquake shall be subject to Paragraph 9.3, notwithstanding that there may be some insurance coverage, but the net proceeds of any such insurance shall be made available for the
repairs if made by either Party. 
 9.3 Partial Damage - Uninsured Loss. If a Premises Partial Damage that is not
an Insured Loss occurs, unless caused by a negligent or willful act of Lessee (in which event Lessee shall make the repairs at Lessee’s expense), Lessor may either: (i) repair such damage as soon as reasonably possible at Lessor’s
expense, in which event this Lease shall continue in full force and effect, or (ii) terminate this Lease by giving written notice to Lessee within 30 days after receipt by Lessor of knowledge of the occurrence of such damage. Such termination
shall be effective 60 days following the date of such notice. In the event Lessor elects to terminate this Lease, Lessee shall have the right within 10 days after receipt of the termination notice to give written notice to Lessor of Lessee’s
commitment to pay for the repair of such damage without reimbursement from Lessor. Lessee shall provide Lessor with said funds or satisfactory assurance thereof within 30 days after making such commitment. In such event this Lease shall continue in
full force and effect, and Lessor shall proceed to make such repairs as soon as reasonably possible after the required funds are available. If Lessee does not make the required commitment, this Lease shall terminate as of the date specified in the
termination notice. 
 9.4 Total Destruction. Notwithstanding any other provision hereof, if a Premises Total
Destruction occurs, this Lease shall terminate 60 days following such Destruction. If the damage or destruction was caused by the gross negligence or willful misconduct of Lessee, Lessor shall have the right to recover Lessor’s damages from
Lessee, except as provided in Paragraph 8.6. 
 9.5 Damage Near End of Term. If at any time during the last 6
months of this Lease there is damage for which the cost to repair exceeds one month’s Base Rent, whether or not an Insured Loss, Lessor may terminate this Lease effective 60 days following the date of occurrence of such damage by giving a
written termination notice to Lessee within 30 days after the date of occurrence of such damage. Notwithstanding the foregoing, if Lessee at that time has an exercisable option to extend this Lease or to purchase the Premises, then Lessee may
preserve this Lease by, (a) exercising such option and (b) providing Lessor with any shortage in insurance proceeds (or adequate assurance thereof) needed to make the repairs on or before the earlier of (i) the date which is 10 days
after Lessee’s receipt of Lessor’s written notice purporting to terminate this Lease, or (ii) the day prior to the date upon which such option expires. If Lessee duly exercises such option during such period and provides Lessor with
funds (or adequate assurance thereof) to cover any shortage in insurance proceeds, Lessor shall, at Lessor’s commercially reasonable expense, repair such damage as soon as reasonably possible and this Lease shall continue in full force and
effect. If Lessee fails to exercise such option and provide such funds or assurance during such period, then this Lease shall terminate on the date specified in the termination notice and Lessee’s option shall be extinguished. 

9.6 Abatement of Rent; Lessee’s Remedies. 

(a) Abatement. In the event of Premises Partial Damage or Premises Total Destruction or a Hazardous Substance Condition for
which Lessee is not responsible under this Lease, the Rent payable by Lessee for the period required for the repair, remediation or restoration of such damage shall be abated in proportion to the degree to which Lessee’s use of the Premises is
impaired, but not to exceed the proceeds received from the Rental Value insurance. All other obligations of Lessee hereunder shall be performed by Lessee, and Lessor shall have no liability for any such damage, destruction, remediation, repair or
restoration except as provided herein. 

                (b) Remedies. If Lessor shall be obligated
to repair or restore the Premises and does not commence, in a substantial and meaningful way, such repair or restoration within 90 days after such obligation shall accrue, Lessee may, at any time prior to the commencement of such repair or
restoration, give written notice to Lessor and to any Lenders of which Lessee has actual notice, of Lessee’s election to terminate this Lease on a date not less than 60 days following the giving of such notice. If Lessee gives such notice and
such repair or restoration is not commenced within 30 days thereafter, this Lease shall terminate as of the date specified in said notice. If the repair or restoration is commenced within such 30 days, this Lease shall continue in full force and
effect. “Commence” shall mean either the unconditional authorization of the preparation of the required plans, or the beginning of the actual work on the Premises, whichever first occurs. 

9.7 Termination; Advance Payments. Upon termination of this Lease pursuant to Paragraph 6.2(g) or Paragraph 9, an equitable
adjustment shall be made concerning advance Base Rent and any other advance payments made by Lessee to Lessor. Lessor shall, in addition, return to Lessee so much of Lessee’s Security Deposit as has not been, or is not then required to be, used
by Lessor. 
 9.8 Waive Statutes. Lessor and Lessee agree that the terms of this Lease shall govern the effect of
any damage to or destruction of the Premises with respect to the termination of this Lease and hereby waive the provisions of any present or future statute to the extent inconsistent herewith. 

10. Real Property Taxes. 

10.1 Definition. As used herein, the term “Real Property Taxes” shall include any form of assessment; real
estate, general, special, ordinary or extraordinary, or rental levy or tax (other than inheritance, personal income or estate taxes); improvement bond; and/or license fee imposed upon or levied against any legal or equitable interest of Lessor in
the Project, Lessor’s right to other income therefrom, and/or Lessor’s business of leasing, by any authority having the direct or indirect power to tax and where the funds are generated with reference to the Project address and where the
proceeds so generated are to be applied by the city, county or other local taxing authority of a jurisdiction within which the Project is located. The term “Real Property Taxes” shall also include any tax, fee, levy, assessment or charge,
or any increase therein, imposed by reason of events occurring during the term of this Lease, including but not limited to, a change in the ownership of the Project or any portion thereof or a change in the improvements thereon. In calculating Real
Property Taxes for any calendar year, the Real Property Taxes for any real estate tax year shall be included in the calculation of Real Property Taxes for such calendar year based upon the number of days which such calendar year and tax year have in
common. 
 10.2 Payment of Taxes. Lessor shall pay the Real Property Taxes applicable to the Project, and except as
otherwise provided in Paragraph 10.3, any such amounts shall be included in the calculation of Common Area Operating Expenses in accordance with the provisions of Paragraph 4.2. 

10.3 Additional Improvements. Common Area Operating Expenses shall not include Real Property Taxes specified in the tax
assessor’s records and work sheets as being caused by additional improvements placed upon the Project by other lessees or by Lessor for the exclusive enjoyment of such other lessees. Notwithstanding Paragraph 10.2 hereof, Lessee shall, however,
pay to Lessor at the time Common Area Operating Expenses are payable under Paragraph 4.2, the entirety of any increase in Real Property Taxes if assessed solely by reason of Alterations, Trade Fixtures or Utility Installations placed upon the
Premises by Lessee or at Lessee’s request. 
 10.4 Joint Assessment. If the Building is not separately
assessed, Real Property Taxes allocated to the Building shall be an equitable proportion of the Real Property Taxes for all of the land and improvements included within the tax parcel assessed, such proportion to be determined by Lessor from the
respective valuations assigned in the assessor’s work sheets or such other information as may be reasonably available. Lessor’s reasonable determination thereof, in good faith, shall be conclusive. 

10.5 Personal Property Taxes. Lessee shall pay prior to delinquency all taxes assessed against and levied upon Lessee Owned
Alterations and Utility Installations, Trade Fixtures, furnishings, equipment and all personal property of Lessee contained in the Premises. When possible, Lessee shall cause its Lessee Owned Alterations and Utility Installations, Trade Fixtures,
furnishings, equipment and all other personal property to be assessed and billed separately from the real property of Lessor. If any of Lessee’s said property shall be assessed with Lessor’s real property, Lessee shall pay Lessor the taxes
attributable to Lessee’s property within 10 days after receipt of a written statement setting forth the taxes applicable to Lessee’s property. 

11. Utilities. Lessee shall pay for all water, gas, heat, light, power, telephone, trash disposal and other utilities and services supplied
to the Premises, together with any taxes thereon. Notwithstanding the provisions of Paragraph 4.2, if at any time in Lessor’s sole judgment, Lessor determines that Lessee is using a disproportionate amount of water, electricity or other
commonly metered utilities, or that Lessee is generating such a large volume of trash as to require an increase in the size of the dumpster and/or an increase in the number of times per month that the dumpster is emptied, then Lessor may increase
Lessee’s Base Rent by an amount equal to such increased costs. 
 12. Assignment and Subletting. 

12.1 Lessor’s Consent Required. 

(a) Lessee shall not voluntarily or by operation of law assign, transfer, mortgage or encumber (collectively, “assign or
assignment”) or sublet all or any part of Lessee’s interest in this Lease or in the Premises without Lessor’s prior written consent. 

(b) A change in the control of Lessee shall constitute an assignment requiring consent. The transfer, on a cumulative basis, of 25%
or more of the voting control of Lessee shall constitute a change in control for this purpose. 
 (c) The involvement of
Lessee or its assets in any transaction, or series of transactions (by way of merger, sale, acquisition, financing, transfer, leveraged buy-out or otherwise), whether or not a formal assignment or hypothecation of this Lease or Lessee’s assets
occurs, which results or will result in a reduction of the Net Worth of Lessee by an amount greater than 25% of such Net Worth as it was represented at the time of the execution of this Lease or at the time of the most recent assignment to which
Lessor has consented, or as it exists immediately prior to said transaction or transactions constituting such reduction, whichever was or is greater, shall be considered an assignment of this Lease to which Lessor may withhold its consent.
“Net Worth of Lessee” shall mean the net worth of Lessee (excluding any guarantors) established under generally accepted accounting principles. 
  

									
		 		  		  		  	
	 	 		  		  		  	 
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 (d) An assignment or subletting without consent shall, at Lessor’s option, be a
Default curable after notice per Paragraph 13.1(c), or a noncurable Breach without the necessity of any notice and grace period. If Lessor elects to treat such unapproved assignment or subletting as a noncurable Breach, Lessor may either:
(i) terminate this Lease, or (ii) upon 30 days written notice, increase the monthly Base Rent to 110% of the Base Rent then in effect. Further, in the event of such Breach and rental adjustment, (i) the purchase price of any option to
purchase the Premises held by Lessee shall be subject to similar adjustment to 110% of the price previously in effect, and (ii) all fixed and non-fixed rental adjustments scheduled during the remainder of the Lease term shall be increased to
110% of the scheduled adjusted rent. 
 (e) Lessee’s remedy for any breach of Paragraph 12.1 by Lessor shall be
limited to compensatory damages and/or injunctive relief. 
 12.2 Terms and Conditions Applicable to Assignment and
Subletting. 
 (a) Regardless of Lessor’s consent, no assignment or subletting shall: (i) be effective
without the express written assumption by such assignee or sublessee of the obligations of Lessee under this Lease, (ii) release Lessee of any obligations hereunder, or (iii) alter the primary liability of Lessee for the payment of Rent or
for the performance of any other obligations to be performed by Lessee. 
 (b) Lessor may accept Rent or performance of
Lessee’s obligations from any person other than Lessee pending approval or disapproval of an assignment. Neither a delay in the approval or disapproval of such assignment nor the acceptance of Rent or performance shall constitute a waiver or
estoppel of Lessor’s right to exercise its remedies for Lessee’s Default or Breach. 
 (c) Lessor’s consent
to any assignment or subletting shall not constitute a consent to any subsequent assignment or subletting. 
 (d) In the
event of any Default or Breach by Lessee, Lessor may proceed directly against Lessee, any Guarantors or anyone else responsible for the performance of Lessee’s obligations under this Lease, including any assignee or sublessee, without first
exhausting Lessor’s remedies against any other person or entity responsible therefore to Lessor, or any security held by Lessor. 

(e) Each request for consent to an assignment or subletting shall be in writing, accompanied by information relevant to
Lessor’s determination as to the financial and operational responsibility and appropriateness of the proposed assignee or sublessee, including but not limited to the intended use and/or required modification of the Premises, if any, together
with a fee of $1,000 or 10% of the current monthly Base Rent applicable to the portion of the Premises which is the subject of the proposed assignment or sublease, whichever is greater, as consideration for Lessor’s considering and processing
said request. Lessee agrees to provide Lessor with such other or additional information and/or documentation as may be reasonably requested. 

(f) Any assignee of, or sublessee under, this Lease shall, by reason of accepting such assignment or entering into such sublease,
be deemed to have assumed and agreed to conform and comply with each and every term, covenant, condition and obligation herein to be observed or performed by Lessee during the term of said assignment or sublease, other than such obligations as are
contrary to or inconsistent with provisions of an assignment or sublease to which Lessor has specifically consented to in writing. 

(g) Lessor’s consent to any assignment or subletting shall not transfer to the assignee or sublessee any Option granted to the
original Lessee by this Lease unless such transfer is specifically consented to by Lessor in writing. (See Paragraph 39.2) 

12.3 Additional Terms and Conditions Applicable to Subletting. The following terms and conditions shall apply to any
subletting by Lessee of all or any part of the Premises and shall be deemed included in all subleases under this Lease whether or not expressly incorporated therein: 

(a) Lessee hereby assigns and transfers to Lessor all of Lessee’s interest in all Rent payable on any sublease, and Lessor may
collect such Rent and apply same toward Lessee’s obligations under this Lease; provided, however, that until a Breach shall occur in the performance of Lessee’s obligations, Lessee may collect said Rent. Lessor shall not, by reason of the
foregoing or any assignment of such sublease, nor by reason of the collection of Rent, be deemed liable to the sublessee for any failure of Lessee to perform and comply with any of Lessee’s obligations to such sublessee. Lessee hereby
irrevocably authorizes and directs any such sublessee, upon receipt of a written notice from Lessor stating that a Breach exists in the performance of Lessee’s obligations under this Lease, to pay to Lessor all Rent due and to become due under
the sublease. Sublessee shall rely upon any such notice from Lessor and shall pay all Rents to Lessor without any obligation or right to inquire as to whether such Breach exists, notwithstanding any claim from Lessee to the contrary. 

(b) In the event of a Breach by Lessee, Lessor may, at its option, require sublessee to attorn to Lessor, in which event Lessor
shall undertake the obligations of the sublessor under such sublease from the time of the exercise of said option to the expiration of such sublease; provided, however, Lessor shall not be liable for any prepaid rents or security deposit paid by
such sublessee to such sublessor or for any prior Defaults or Breaches of such sublessor. 
 (c) Any matter requiring the
consent of the sublessor under a sublease shall also require the consent of Lessor. 
 (d) No sublessee shall further
assign or sublet all or any part of the Premises without Lessor’s prior written consent. 
 (e) Lessor shall deliver
a copy of any notice of Default or Breach by Lessee to the sublessee, who shall have the right to cure the Default of Lessee within the grace period, if any, specified in such notice. The sublessee shall have a right of reimbursement and offset from
and against Lessee for any such Defaults cured by the sublessee. 
 13. Default; Breach; Remedies. 

13.1 Default; Breach. A “Default” is defined as a failure by the Lessee to comply with or perform any of
the terms, covenants, conditions or Rules and Regulations under this Lease. A “Breach” is defined as the occurrence of one or more of the following Defaults, and the failure of Lessee to cure such Default within any applicable grace
period: 
 (a) The abandonment of the Premises; or the vacating of the Premises without providing a commercially
reasonable level of security, or where the coverage of the property insurance described in Paragraph 8.3 is jeopardized as a result thereof, or without providing reasonable assurances to minimize potential vandalism. 

(b) The failure of Lessee to make any payment of Rent or any Security Deposit required to be made by Lessee hereunder, whether to
Lessor or to a third party, when due, to provide reasonable evidence of insurance or surety bond, or to fulfill any obligation under this Lease which endangers or threatens life or property, where such failure continues for a period of 3 business
days following written notice to Lessee. 
 (c) The failure by Lessee to provide (i) reasonable written evidence of
compliance with Applicable Requirements, (ii) the service contracts, (iii) the rescission of an unauthorized assignment or subletting, (iv) an Estoppel Certificate, (v) a requested subordination, (vi) evidence concerning any
guaranty and/or Guarantor, (vii) any document requested under Paragraph 41 (easements), or, (viii) or any other documentation or information which Lessor may reasonably require of Lessee under the terms of this Lease, where any such
failure continues for a period of 10 days following written notice to Lessee. 
 (d) A Default by Lessee as to the terms,
covenants, conditions or provisions of this Lease, or of the rules adopted under Paragraph 2.9 hereof, other than those described in subparagraphs 13.1(a), (b) or (c), above, where such Default continues for a period of 30 days after written
notice; provided, however, that if the nature of Lessee’s Default is such that more than 30 days are reasonably required for its cure, then it shall not be deemed to be a Breach if Lessee commences such cure within said 30 day period and
thereafter diligently prosecutes such cure to completion. 
 (e) The occurrence of any of the following events:
(i) the making of any general arrangement or assignment for the benefit of creditors; (ii) becoming a “debtor” as defined in 11 U.S.C. § 101 or any successor statute thereto (unless, in the case of a petition filed
against Lessee, the same is dismissed within 60 days); (iii) the appointment of a trustee or receiver to take possession of substantially all of Lessee’s assets located at the Premises or of Lessee’s interest in this Lease, where
possession is not restored to Lessee within 30 days; or (iv) the attachment, execution or other judicial seizure of substantially all of Lessee’s assets located at the Premises or of Lessee’s interest in this Lease, where such seizure
is not discharged within 30 days; provided, however, in the event that any provision of this subparagraph (e) is contrary to any applicable law, such provision shall be of no force or effect, and not affect the validity of the remaining
provisions. 
 (f) The discovery that any financial statement of Lessee or of any Guarantor given to Lessor was materially
false. 
 (g) If the performance of Lessee’s obligations under this Lease is guaranteed: (i) the death of a
Guarantor, (ii) the termination of a Guarantor’s liability with respect to this Lease other than in accordance with the terms of such guaranty, (iii) a Guarantor’s becoming insolvent or the subject of a bankruptcy filing,
(iv) a Guarantor’s refusal to honor the guaranty, or (v) a Guarantor’s breach of its guaranty obligation on an anticipatory basis, and Lessee’s failure, within 60 days following written notice of any such event, to provide
written alternative assurance or security, which, when coupled with the then existing resources of Lessee, equals or exceeds the combined financial resources of Lessee and the Guarantors that existed at the time of execution of this Lease.

 13.2 Remedies. If Lessee fails to perform any of its affirmative duties or obligations, within 10 days after
written notice (or in case of an emergency, without notice), Lessor may, at its option, perform such duty or obligation on Lessee’s behalf, including but not limited to the obtaining of reasonably required bonds, insurance policies, or
governmental licenses, permits or approvals. The costs and expenses of any such performance by Lessor shall be due and payable by Lessee upon receipt of invoice therefor. If any check given to Lessor by Lessee shall not be honored by the bank upon
which it is drawn, Lessor, at its option, may require all future payments to be made by Lessee to be by cashier’s check. In the event of a Breach, Lessor may, with or without further notice or demand, and without limiting Lessor in the exercise
of any right or remedy which Lessor may have by reason of such Breach: 
 (a) Terminate Lessee’s right to possession
of the Premises by any lawful means, in which case this Lease shall terminate and Lessee shall immediately surrender possession to Lessor. In such event Lessor shall be entitled to recover from Lessee: (i) the unpaid Rent which had been earned
at the time of termination; (ii) the worth at the time of award of the amount by which the unpaid rent which would have been earned after termination until the time of award exceeds the amount of such rental loss that the Lessee proves could
have been reasonably avoided; (iii) the worth at the time of award of the amount by which the unpaid rent for the balance of the term after the time of award exceeds the amount of such rental loss that the Lessee proves could be reasonably
avoided; and (iv) any other amount necessary to compensate Lessor for all the detriment proximately caused by the Lessee’s failure to perform its obligations under this Lease or which in the ordinary course of things would be likely to
result therefrom, including but not limited to the cost of recovering possession of the Premises, expenses of reletting, including necessary renovation and alteration of the Premises, reasonable attorneys’ fees, and that portion of any leasing
commission paid by Lessor in connection with this Lease applicable to the unexpired term of this Lease. The worth at the time of award of the amount referred to in provision (iii) of the immediately preceding sentence shall be computed by
discounting such amount at the discount rate of the Federal Reserve Bank of the District within which the Premises are located at the time of award plus one percent. Efforts by Lessor to mitigate damages caused by Lessee’s Breach of this Lease
shall not waive Lessor’s right to recover damages under Paragraph 12. If termination of this Lease is obtained 

 

									
		 		  		  		  	
	 	 		  		  		  	 
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through the provisional remedy of unlawful detainer, Lessor shall have the right to recover in such proceeding any unpaid Rent and damages as are recoverable therein, or Lessor may reserve the
right to recover all or any part thereof in a separate suit. If a notice and grace period required under Paragraph 13.1 was not previously given, a notice to pay rent or quit, or to perform or quit given to Lessee under the unlawful detainer statute
shall also constitute the notice required by Paragraph 13.1. In such case, the applicable grace period required by Paragraph 13.1 and the unlawful detainer statute shall run concurrently, and the failure of Lessee to cure the Default within the
greater of the two such grace periods shall constitute both an unlawful detainer and a Breach of this Lease entitling Lessor to the remedies provided for in this Lease and/or by said statute. 

(b) Continue the Lease and Lessee’s right to possession and recover the Rent as it becomes due, in which event Lessee may
sublet or assign, subject only to reasonable limitations. Acts of maintenance, efforts to relet, and/or the appointment of a receiver to protect the Lessor’s interests, shall not constitute a termination of the Lessee’s right to
possession. 
 (c) Pursue any other remedy now or hereafter available under the laws or judicial decisions of the state
wherein the Premises are located. The expiration or termination of this Lease and/or the termination of Lessee’s right to possession shall not relieve Lessee from liability under any indemnity provisions of this Lease as to matters occurring or
accruing during the term hereof or by reason of Lessee’s occupancy of the Premises. 
 13.3 Inducement
Recapture. Any agreement for free or abated rent or other charges, or for the giving or paying by Lessor to or for Lessee of any cash or other bonus, inducement or consideration for Lessee’s entering into this Lease, all of which
concessions are hereinafter referred to as “Inducement Provisions”, shall be deemed conditioned upon Lessee’s full and faithful performance of all of the terms, covenants and conditions of this Lease. Upon Breach of this Lease
by Lessee, any such Inducement Provision shall automatically be deemed deleted from this Lease and of no further force or effect, and any rent, other charge, bonus, inducement or consideration theretofore abated, given or paid by Lessor under such
an Inducement Provision shall be immediately due and payable by Lessee to Lessor, notwithstanding any subsequent cure of said Breach by Lessee. The acceptance by Lessor of rent or the cure of the Breach which initiated the operation of this
paragraph shall not be deemed a waiver by Lessor of the provisions of this paragraph unless specifically so stated in writing by Lessor at the time of such acceptance. 

13.4 Late Charges. Lessee hereby acknowledges that late payment by Lessee of Rent will cause Lessor to incur costs not
contemplated by this Lease, the exact amount of which will be extremely difficult to ascertain. Such costs include, but are not limited to, processing and accounting charges, and late charges which may be imposed upon Lessor by any Lender.
Accordingly, if any Rent shall not be received by Lessor within 5 days after such amount shall be due, then, without any requirement for notice to Lessee, Lessee shall pay to Lessor a one-time late charge equal to 10% of each such overdue amount or
$100, whichever is greater. The parties hereby agree that such late charge represents a fair and reasonable estimate of the costs Lessor will incur by reason of such late payment. Acceptance of such late charge by Lessor shall in no event constitute
a waiver of Lessee’s Default or Breach with respect to such overdue amount, nor prevent the exercise of any of the other rights and remedies granted hereunder. In the event that a late charge is payable hereunder, whether or not collected, for
3 consecutive installments of Base Rent, then notwithstanding any provision of this Lease to the contrary, Base Rent shall, at Lessor’s option, become due and payable quarterly in advance. 

13.5 Interest. Any monetary payment due Lessor hereunder, other than late charges, not received by Lessor, when due as to
scheduled payments (such as Base Rent) or within 30 days following the date on which it was due for non-scheduled payment, shall bear interest from the date when due, as to scheduled payments, or the 31st day after it was due as to non-scheduled
payments. The interest (“Interest”) charged shall be equal to the prime rate reported in the Wall Street Journal as published closest prior to the date when due plus 4%, but shall not exceed the maximum rate allowed by law. Interest
is payable in addition to the potential late charge provided for in Paragraph 13.4. 
 13.6 Breach by Lessor.

 (a) Notice of Breach. Lessor shall not be deemed in breach of this Lease unless Lessor fails within a reasonable
time to perform an obligation required to be performed by Lessor. For purposes of this Paragraph, a reasonable time shall in no event be less than 30 days after receipt by Lessor, and any Lender whose name and address shall have been furnished
Lessee in writing for such purpose, of written notice specifying wherein such obligation of Lessor has not been performed; provided, however, that if the nature of Lessor’s obligation is such that more than 30 days are reasonably required for
its performance, then Lessor shall not be in breach if performance is commenced within such 30 day period and thereafter diligently pursued to completion. 

                (b) Performance by Lessee on Behalf of
Lessor. In the event that neither Lessor nor Lender cures said breach within 30 days after receipt of said notice, or if having commenced said cure they do not diligently pursue it to completion, then Lessee may elect to cure said breach at
Lessee’s expense and offset from Rent an amount equal to the greater of one month’s Base Rent or the Security Deposit, and to pay an excess of such expense under protest, reserving Lessee’s right to reimbursement from Lessor. Lessee
shall document the cost of said cure and supply said documentation to Lessor. 
 14. Condemnation. If the Premises or any portion
thereof are taken under the power of eminent domain or sold under the threat of the exercise of said power (collectively “Condemnation”), this Lease shall terminate as to the part taken as of the date the condemning authority takes
title or possession, whichever first occurs. If more than 10% of the floor area of the Unit, or more than 25% of Lessee’s Reserved Parking Spaces, is taken by Condemnation, Lessee may, at Lessee’s option, to be exercised in writing within
10 days after Lessor shall have given Lessee written notice of such taking (or in the absence of such notice, within 10 days after the condemning authority shall have taken possession) terminate this Lease as of the date the condemning authority
takes such possession. If Lessee does not terminate this Lease in accordance with the foregoing, this Lease shall remain in full force and effect as to the portion of the Premises remaining, except that the Base Rent shall be reduced in proportion
to the reduction in utility of the Premises caused by such Condemnation. Condemnation awards and/or payments shall be the property of Lessor, whether such award shall be made as compensation for diminution in value of the leasehold, the value of the
part taken, or for severance damages; provided, however, that Lessee shall be entitled to any compensation for Lessee’s relocation expenses, loss of business goodwill and/or Trade Fixtures, without regard to whether or not this Lease is
terminated pursuant to the provisions of this Paragraph. All Alterations and Utility Installations made to the Premises by Lessee, for purposes of Condemnation only, shall be considered the property of the Lessee and Lessee shall be entitled to any
and all compensation which is payable therefor. In the event that this Lease is not terminated by reason of the Condemnation, Lessor shall repair any damage to the Premises caused by such Condemnation. 

15. Brokerage Fees. 

15.1 Additional Commission. In addition to the payments owed pursuant to Paragraph 1.10 above, and unless Lessor and
the Brokers otherwise agree in writing, Lessor agrees that: (a) if Lessee exercises any Option, (b) if Lessee acquires from Lessor any rights to the Premises or other premises owned by Lessor and located within the Project,
(c) if Lessee remains in possession of the Premises, with the consent of Lessor, after the expiration of this Lease, or (d) if Base Rent is increased, whether by agreement or operation of an escalation clause herein, then,
Lessor shall pay Brokers a fee in accordance with the schedule of the Brokers in effect at the time of the execution of this Lease. 

15.2 Assumption of Obligations. Any buyer or transferee of Lessor’s interest in this Lease shall be deemed to
have assumed Lessor’s obligation hereunder. Brokers shall be third party beneficiaries of the provisions of Paragraphs 1.10, 15, 22 and 31. If Lessor fails to pay to Brokers any amounts due as and for brokerage fees pertaining to this Lease
when due, then such amounts shall accrue Interest. In addition, if Lessor fails to pay any amounts to Lessee’s Broker when due, Lessee’s Broker may send written notice to Lessor and Lessee of such failure and if Lessor fails to pay such
amounts within 10 days after said notice, Lessee shall pay said monies to its Broker and offset such amounts against Rent. In addition, Lessee’s Broker shall be deemed to be a third party beneficiary of any commission agreement entered into by
and/or between Lessor and Lessor’s Broker for the limited purpose of collecting any brokerage fee owed. 

15.3 Representations and Indemnities of Broker Relationships. Lessee and Lessor each represent and warrant to the other that
it has had no dealings with any person, firm, broker or finder (other than the Brokers, if any) in connection with this Lease, and that no one other than said named Brokers is entitled to any commission or finder’s fee in connection herewith.
Lessee and Lessor do each hereby agree to indemnify, protect, defend and hold the other harmless from and against liability for compensation or charges which may be claimed by any such unnamed broker, finder or other similar party by reason of any
dealings or actions of the indemnifying Party, including any costs, expenses, attorneys’ fees reasonably incurred with respect thereto. 

16. Estoppel Certificates. 

(a) Each Party (as “Responding Party”) shall within 10 days after written notice from the other Party (the
“Requesting Party”) execute, acknowledge and deliver to the Requesting Party a statement in writing in form similar to the then most current “Estoppel Certificate” form published by the American Industrial Real
Estate Association, or as may be reasonably required by a purchaser, lender, or the Lessor, plus such additional information, confirmation and/or statements as may be reasonably requested by the Requesting Party. 

                (b) If the Responding Party shall fail to execute
or deliver the Estoppel Certificate within such 10 day period, the Requesting Party may execute an Estoppel Certificate stating that: (i) the Lease is in full force and effect without modification except as may be represented by the Requesting
Party, (ii) there are no uncured defaults in the Requesting Party’s performance, and (iii) if Lessor is the Requesting Party, not more than one month’s rent has been paid in advance. Prospective purchasers and encumbrancers may
rely upon the Requesting Party’s Estoppel Certificate, and the Responding Party shall be estopped from denying the truth of the facts contained in said Certificate. 

(c) If Lessor desires to finance, refinance, or sell the Premises, or any part thereof, Lessee and all Guarantors shall deliver to
any potential lender or purchaser designated by Lessor such financial statements as may be reasonably required by such lender or purchaser, including but not limited to Lessee’s financial statements for the past 3 years. All such financial
statements shall be received by Lessor and such lender or purchaser in confidence and shall be used only for the purposes herein set forth. 

17. Definition of Lessor. The term “Lessor” as used herein shall mean the owner or owners at the time in question of the
fee title to the Premises, or, if this is a sublease, of the Lessee’s interest in the prior lease. In the event of a transfer of Lessor’s title or interest in the Premises or this Lease, Lessor shall deliver to the transferee or assignee
(in cash or by credit) any unused Security Deposit held by Lessor. Except as provided in Paragraph 15, upon such transfer or assignment and delivery of the Security Deposit, as aforesaid, the prior Lessor shall be relieved of all liability with
respect to the obligations and/or covenants under this Lease thereafter to be performed by the Lessor. Subject to the foregoing, the obligations and/or covenants in this Lease to be performed by the Lessor shall be binding only upon the Lessor as
hereinabove defined. Notwithstanding the above, and subject to the provisions of 
  

									
		 		  		  		  	
	 	 		  		  		  	 
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Paragraph 20 below, the original Lessor under this Lease, and all subsequent holders of the Lessor’s interest in this Lease shall remain liable and responsible with regard to the potential
duties and liabilities of Lessor pertaining to Hazardous Substances as outlined in Paragraph 6.2 above. 
 18. Severability. The
invalidity of any provision of this Lease, as determined by a court of competent jurisdiction, shall in no way affect the validity of any other provision hereof. 

19. Days. Unless otherwise specifically indicated to the contrary, the word “days” as used in this Lease shall mean and
refer to calendar days. 
 20. Limitation on Liability. Subject to the provisions of Paragraph 17 above, the obligations of Lessor
under this Lease shall not constitute personal obligations of Lessor, the individual partners of Lessor or its or their individual partners, directors, officers or shareholders, and Lessee shall look to the Premises, and to no other assets of
Lessor, for the satisfaction of any liability of Lessor with respect to this Lease, and shall not seek recourse against the individual partners of Lessor or its or their individual partners, directors, officers or shareholders, or any of their
personal assets for such satisfaction. 
 21. Time of Essence. Time is of the essence with respect to the performance of all
obligations to be performed or observed by the Parties under this Lease. 
 22. No Prior or Other Agreements; Broker Disclaimer.
This Lease contains all agreements between the Parties with respect to any matter mentioned herein, and no other prior or contemporaneous agreement or understanding shall be effective. Lessor and Lessee each represents and warrants to the Brokers
that it has made, and is relying solely upon, its own investigation as to the nature, quality, character and financial responsibility of the other Party to this Lease and as to the use, nature, quality and character of the Premises. Brokers have no
responsibility with respect thereto or with respect to any default or breach hereof by either Party. The liability (including court costs and attorneys’ fees), of any Broker with respect to negotiation, execution, delivery or performance by
either Lessor or Lessee under this Lease or any amendment or modification hereto shall be limited to an amount up to the fee received by such Broker pursuant to this Lease, provided, however, that the foregoing limitation on each Broker’s
liability shall not be applicable to any gross negligence or willful misconduct of such Broker. 
 23. Notices. 

23.1 Notice Requirements. All notices required or permitted by this Lease or applicable law shall be in writing and may be
delivered in person (by hand or by courier) or may be sent by regular, certified or registered mail or U.S. Postal Service Express Mail, with postage prepaid, or by facsimile transmission, and shall be deemed sufficiently given if served in a manner
specified in this Paragraph 23. The addresses noted adjacent to a Party’s signature on this Lease shall be that Party’s address for delivery or mailing of notices except in the case of Lessor in which case Notice must be concurrently
delivered to (a) the Property Manager and (b) Sig Luther at 401 West “A” Street #1625, San Diego, CA 92101, Tel. 619-239-0755, Fax 619-239-0541. Either Party may by written notice to the other specify a different address for
notice, except that upon Lessee’s taking possession of the Premises, the Premises shall constitute Lessee’s address for notice. A copy of all notices to Lessor shall be concurrently transmitted to such party or parties at such addresses as
Lessor may from time to time hereafter designate in writing. 
 23.2 Date of Notice. Any notice sent by registered
or certified mail, return receipt requested, shall be deemed given on the date of delivery shown on the receipt card, or if no delivery date is shown, the postmark thereon. If sent by regular mail the notice shall be deemed given 48 hours after the
same is addressed as required herein and mailed with postage prepaid. Notices delivered by United States Express Mail or overnight courier that guarantee next day delivery shall be deemed given 24 hours after delivery of the same to the Postal
Service or courier. Notices transmitted by facsimile transmission or similar means shall be deemed delivered upon telephone confirmation of receipt (confirmation report from fax machine is sufficient), provided a copy is also delivered via delivery
or mail. If notice is received on a Saturday, Sunday or legal holiday, it shall be deemed received on the next business day. 
 24.
Waivers. No waiver by Lessor of the Default or Breach of any term, covenant or condition hereof by Lessee, shall be deemed a waiver of any other term, covenant or condition hereof, or of any subsequent Default or Breach by Lessee of the same
or of any other term, covenant or condition hereof. Lessor’s consent to, or approval of, any act shall not be deemed to render unnecessary the obtaining of Lessor’s consent to, or approval of, any subsequent or similar act by Lessee, or be
construed as the basis of an estoppel to enforce the provision or provisions of this Lease requiring such consent. The acceptance of Rent by Lessor shall not be a waiver of any Default or Breach by Lessee. Any payment by Lessee may be accepted by
Lessor on account of moneys or damages due Lessor, notwithstanding any qualifying statements or conditions made by Lessee in connection therewith, which such statements and/or conditions shall be of no force or effect whatsoever unless specifically
agreed to in writing by Lessor at or before the time of deposit of such payment. 
 25. Disclosures Regarding The Nature of a
Real Estate Agency Relationship. 
 (a) When entering into a discussion with a real estate agent
regarding a real estate transaction, a Lessor or Lessee should from the outset understand what type of agency relationship or representation it has with the agent or agents in the transaction. Lessor and Lessee acknowledge being advised by the
Brokers in this transaction, as follows: 
 (i) Lessor’s
Agent. A Lessor’s agent under a listing agreement with the Lessor acts as the agent for the Lessor only. A Lessor’s agent or subagent has the following affirmative obligations: To the
Lessor: A fiduciary duty of utmost care, integrity, honesty, and loyalty in dealings with the Lessor. To the Lessee and the Lessor: (a) Diligent exercise of reasonable skills and care in performance of the
agent’s duties. (b) A duty of honest and fair dealing and good faith. (c) A duty to disclose all facts known to the agent materially affecting the value or desirability of the property that are not known to, or within the diligent
attention and observation of, the Parties. An agent is not obligated to reveal to either Party any confidential information obtained from the other Party which does not involve the affirmative duties set forth above. 

(ii) Lessee’s Agent. An agent can agree to act
as agent for the Lessee only. In these situations, the agent is not the Lessor’s agent, even if by agreement the agent may receive compensation for services rendered, either in full or in part from the Lessor. An agent acting only for a Lessee
has the following affirmative obligations. To the Lessee: A fiduciary duty of utmost care, integrity, honesty, and loyalty in dealings with the Lessee. To the Lessee and the Lessor: (a) Diligent
exercise of reasonable skills and care in performance of the agent’s duties. (b) A duty of honest and fair dealing and good faith. (c) A duty to disclose all facts known to the agent materially affecting the value or desirability of
the property that are not known to, or within the diligent attention and observation of, the Parties. An agent is not obligated to reveal to either Party any confidential information obtained from the other Party which does not involve the
affirmative duties set forth above. 
 (iii) Agent Representing Both
Lessor and Lessee. A real estate agent, either acting directly or through one or more associate licenses, can legally be the agent of both the Lessor and the Lessee in a transaction, but only with the
knowledge and consent of both the Lessor and the Lessee. In a dual agency situation, the agent has the following affirmative obligations to both the Lessor and the Lessee: (a) A fiduciary duty of utmost care, integrity, honesty and loyalty in
the dealings with either Lessor or the Lessee. (b) Other duties to the Lessor and the Lessee as stated above in subparagraphs (i) or (ii). In representing both Lessor and Lessee, the agent may not without the express permission of the
respective Party, disclose to the other Party that the Lessor will accept rent in an amount less than that indicated in the listing or that the Lessee is willing to pay a higher rent than that offered. The above duties of the agent in a real estate
transaction do not relieve a Lessor or Lessee from the responsibility to protect their own interests. Lessor and Lessee should carefully read all agreements to assure that they adequately express their understanding of the transaction. A real estate
agent is a person qualified to advise about real estate. If legal or tax advice is desired, consult a competent professional. 

(b) Brokers have no responsibility with respect to any default or breach hereof by either Party. The Parties agree that no
lawsuit or other legal proceeding involving any breach of duty, error or omission relating to this Lease may be brought against Broker more than one year after the Start Date and that the liability (including court costs and attorneys’ fees),
of any Broker with respect to any such lawsuit and/or legal proceeding shall not exceed the fee received by such Broker pursuant to this Lease; provided, however, that the foregoing limitation on each Broker’s liability shall not be applicable
to any gross negligence or willful misconduct of such Broker. 
 (c) Buyer and Seller agree to identify
to Brokers as “Confidential” any communication or information given Brokers that is considered by such Party to be confidential. 

26. No Right To Holdover. Lessee has no right to retain possession of the Premises or any part thereof beyond the expiration or termination
of this Lease. In the event that Lessee holds over, then the Base Rent shall be increased to 150% of the Base Rent applicable immediately preceding the expiration or termination and Lessee shall pay Lessor for any and all costs and/or damages
incurred by Lessor as a result of any holdover by Lessee. Nothing contained herein shall be construed as consent by Lessor to any holding over by Lessee. 

27. Cumulative Remedies. No remedy or election hereunder shall be deemed exclusive but shall, wherever possible, be cumulative with all
other remedies at law or in equity. 
 28. Covenants and Conditions; Construction of Agreement. All provisions of this Lease to be
observed or performed by Lessee are both covenants and conditions. In construing this Lease, all headings and titles are for the convenience of the Parties only and shall not be considered a part of this Lease. Whenever required by the context, the
singular shall include the plural and vice versa. This Lease shall not be construed as if prepared by one of the Parties, but rather according to its fair meaning as a whole, as if both Parties had prepared it. 

29. Binding Effect; Choice of Law. This Lease shall be binding upon the parties, their personal representatives, successors and assigns and
be governed by the laws of the State in which the Premises are located. Any litigation between the Parties hereto concerning this Lease shall be initiated in the county in which the Premises are located. 

30. Subordination; Attornment; Non-Disturbance. 

30.1 Subordination. This Lease and any Option granted hereby shall be subject and subordinate to any ground lease, mortgage,
deed of trust, or other hypothecation or security device (collectively, “Security Device”), now or hereafter placed upon the Premises, to any and all advances made on the security thereof, and to all renewals, modifications, and
extensions thereof. Lessee agrees that the holders of any such Security Devices (in this Lease together referred to as “Lender”) shall have no liability or obligation to perform any of the obligations of Lessor under this Lease. Any
Lender may elect to have this Lease and/or any Option granted hereby superior to the lien of its Security Device by giving written notice thereof to Lessee, whereupon this Lease and such Options shall be deemed prior to such Security Device,
notwithstanding the relative dates of the documentation or recordation thereof. 
 30.2 Attornment. In the event
that Lessor transfers title to the Premises, or the Premises are acquired by another upon the foreclosure or termination of a Security Device to which this Lease is subordinated (i) Lessee shall, subject to the non-disturbance provisions of
Paragraph 30.3, attorn to 
  

									
		 		  		  		  	
	 	 		  		  		  	 
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such new owner, and upon request, enter into a new lease, containing all of the terms and provisions of this Lease, with such new owner for the remainder of the term hereof, or, at the election
of such new owner, this Lease shall automatically become a new lease between Lessee and such new owner, upon all of the terms and conditions hereof, for the remainder of the term hereof, and (ii) Lessor shall thereafter be relieved of any
further obligations hereunder and such new owner shall assume all of Lessor’s obligations hereunder, except that such new owner shall not: (a) be liable for any act or omission of any prior lessor or with respect to events occurring prior
to acquisition of ownership, (b) be subject to any offsets or defenses which Lessee might have against any prior lessor, (c) be bound by prepayment of more than one month’s rent, or (d) be liable for the return of any security
deposit paid to any prior lessor. Upon any Default by Lessor in the performance of Lessor’s obligations under any mortgage, deed of trust, ground lease, lease-back lease, or assignment, Lessee (and any Sublessee) shall attorn to the mortgagee,
ground lessor, lease-back lessor or assignee thereunder upon demand and shall execute and deliver any instrument or instruments confirming the attornment herein provided. Lessee shall, upon Lessor’s request, subordinate the Lease in the future
to any first, second, or third lien placed upon the Premises by Lessor provided such lender executes a commercially reasonable non-disturbance agreement. 

30.3 Non-Disturbance. With respect to Security Devices entered into by Lessor after the execution of this Lease,
Lessee’s subordination of this Lease shall be subject to receiving a commercially reasonable non-disturbance agreement (a “Non-Disturbance Agreement”) from the Lender which Non-Disturbance Agreement provides that Lessee’s
possession of the Premises, and this Lease, including any options to extend the term hereof, will not be disturbed so long as Lessee is not in Breach hereof and attorns to the record owner of the Premises. Further, within 60 days after the execution
of this Lease, Lessor shall use its commercially reasonable efforts to obtain a Non-Disturbance Agreement from the holder of any pre-existing Security Device which is secured by the Premises. In the event that Lessor is unable to provide the
Non-Disturbance Agreement within said 60 days, then Lessee may, at Lessee’s option, directly contact Lender and attempt to negotiate for the execution and delivery of a Non-Disturbance Agreement. 

30.4 Self-Executing. The agreements contained in this Paragraph 30 shall be effective without the execution of any further
documents; provided, however, that, upon written request from Lessor or a Lender in connection with a sale, financing or refinancing of the Premises, Lessee and Lessor shall execute such further writings as may be reasonably required to separately
document any subordination, attornment and/or Non-Disturbance Agreement provided for herein. 
 31. Attorneys’
Fees. If any Party or Broker brings an action or proceeding involving the Premises whether founded in tort, contract or equity, or to declare rights hereunder, the Prevailing Party (as hereafter defined) in any such proceeding, action, or appeal
thereon, shall be entitled to reasonable attorneys’ fees. Such fees may be awarded in the same suit or recovered in a separate suit, whether or not such action or proceeding is pursued to decision or judgment. The term, “Prevailing
Party” shall include, without limitation, a Party or Broker who substantially obtains or defeats the relief sought, as the case may be, whether by compromise, settlement, judgment, or the abandonment by the other Party or Broker of its
claim or defense. The attorneys’ fees award shall not be computed in accordance with any court fee schedule, but shall be such as to fully reimburse all attorneys’ fees reasonably incurred. In addition, Lessor shall be entitled to
attorneys’ fees, costs and expenses incurred in the preparation and service of notices of Default and consultations in connection therewith, whether or not a legal action is subsequently commenced in connection with such Default or resulting
Breach ($200 is a reasonable minimum per occurrence for such services and consultation). Lessor shall be further entitled to recover reasonable attorney’s fees incurred in connection with any hearing or motion for assumption or rejection of the
Lease under Title 11 of the United States Code. 
 32. Lessor’s Access; Showing Premises; Repairs. Lessor and Lessor’s
agents shall have the right to enter the Premises at any time, in the case of an emergency, and otherwise at reasonable times for the purpose of showing the same to prospective purchasers, lenders, or tenants, and making such alterations, repairs,
improvements or additions to the Premises as Lessor may deem necessary. All such activities shall be without abatement of rent or liability to Lessee. Lessor may at any time place on the Premises any ordinary “For Sale” signs and Lessor
may during the last 6 months of the term hereof place on the Premises any ordinary “For Lease” signs. Lessee may at any time place on the Premises any ordinary “For Sublease” sign. 

33. Auctions. Lessee shall not conduct, nor permit to be conducted, any auction upon the Premises without Lessor’s prior written
consent. Lessor shall not be obligated to exercise any standard of reasonableness in determining whether to permit an auction. 
 34.
Signs. Except for ordinary “For Sublease” signs which may be placed only on the Premises, Lessee shall not place any sign upon the Project without Lessor’s prior written consent. All signs must comply with all Applicable
Requirements. 
 35. Termination; Merger. Unless specifically stated otherwise in writing by Lessor, the voluntary or other
surrender of this Lease by Lessee, the mutual termination or cancellation hereof, or a termination hereof by Lessor for Breach by Lessee, shall automatically terminate any sublease or lesser estate in the Premises; provided, however, that Lessor may
elect to continue any one or all existing subtenancies. Lessor’s failure within 10 days following any such event to elect to the contrary by written notice to the holder of any such lesser interest, shall constitute Lessor’s election to
have such event constitute the termination of such interest. 
 36. Consents. Except as otherwise provided herein, wherever in this
Lease the consent of a Party is required to an act by or for the other Party, such consent shall not be unreasonably withheld or delayed. Lessor’s actual reasonable costs and expenses (including but not limited to architects’,
attorneys’, engineers’ and other consultants’ fees) incurred in the consideration of, or response to, a request by Lessee for any Lessor consent, including but not limited to consents to an assignment, a subletting or the presence or
use of a Hazardous Substance, shall be paid by Lessee upon receipt of an invoice and supporting documentation therefor. Lessor’s consent to any act, assignment or subletting shall not constitute an acknowledgment that no Default or Breach by
Lessee of this Lease exists, nor shall such consent be deemed a waiver of any then existing Default or Breach, except as may be otherwise specifically stated in writing by Lessor at the time of such consent. The failure to specify herein any
particular condition to Lessor’s consent shall not preclude the imposition by Lessor at the time of consent of such further or other conditions as are then reasonable with reference to the particular matter for which consent is being given. In
the event that either Party disagrees with any determination made by the other hereunder and reasonably requests the reasons for such determination, the determining party shall furnish its reasons in writing and in reasonable detail within 10
business days following such request. 
 37. Guarantor. 

37.1 Execution. The Guarantors, if any, shall each execute a guaranty in the form most recently published by the American
Industrial Real Estate Association, and each such Guarantor shall have the same obligations as Lessee under this Lease. 

37.2 Default. It shall constitute a Default of the Lessee if any Guarantor fails or refuses, upon request to provide:
(a) evidence of the execution of the guaranty, including the authority of the party signing on Guarantor’s behalf to obligate Guarantor, and in the case of a corporate Guarantor, a certified copy of a resolution of its board of directors
authorizing the making of such guaranty, (b) current financial statements, (c) an Estoppel Certificate, or (d) written confirmation that the guaranty is still in effect. 

38. Quiet Possession. Subject to payment by Lessee of the Rent and performance of all of the covenants, conditions and provisions on
Lessee’s part to be observed and performed under this Lease, Lessee shall have quiet possession and quiet enjoyment of the Premises during the term hereof. 

39. Options. If Lessee is granted an option, as defined below, then the following provisions shall apply. 

39.1 Definition. “Option” shall mean: (a) the right to extend the term of or renew this Lease or to extend or
renew any lease that Lessee has on other property of Lessor; (b) the right of first refusal or first offer to lease either the Premises or other property of Lessor; (c) the right to purchase or the right of first refusal to purchase the
Premises or other property of Lessor. 
 39.2 Options Personal To Original Lessee. Any Option granted to Lessee in
this Lease is personal to the original Lessee, and cannot be assigned or exercised by anyone other than said original Lessee and only while the original Lessee is in full possession of the Premises and, if requested by Lessor, with Lessee certifying
that Lessee has no intention of thereafter assigning or subletting. 
 39.3 Multiple Options. In the event that
Lessee has any multiple Options to extend or renew this Lease, a later Option cannot be exercised unless the prior Options have been validly exercised. 

39.4 Effect of Default on Options. 

(a) Lessee shall have no right to exercise an Option: (i) during the period commencing with the giving of any notice
of Default and continuing until said Default is cured, (ii) during the period of time any Rent is unpaid (without regard to whether notice thereof is given Lessee), (iii) during the time Lessee is in Breach of this Lease, or (iv) in
the event that Lessee has been given 3 or more notices of separate Default, whether or not the Defaults are cured, during the 12 month period immediately preceding the exercise of the Option. 

(b) The period of time within which an Option may be exercised shall not be extended or enlarged by reason of Lessee’s
inability to exercise an Option because of the provisions of Paragraph 39.4(a). 

                (c) An Option shall terminate and be of no
further force or effect, notwithstanding Lessee’s due and timely exercise of the Option, if, after such exercise and prior to the commencement of the extended term or completion of the purchase, (i) Lessee fails to pay Rent for a period of
30 days after such Rent becomes due (without any necessity of Lessor to give notice thereof), (ii) Lessor gives to Lessee 3 or more notices of separate Default during any 12 month period, whether or not the Defaults are cured, or (iii) if
Lessee commits a Breach of this Lease. 
 40. Security Measures. Lessee hereby acknowledges that the Rent payable to
Lessor hereunder does not include the cost of guard service or other security measures, and that Lessor shall have no obligation whatsoever to provide same. Lessee assumes all responsibility for the protection of the Premises, Lessee, its agents and
invitees and their property from the acts of third parties. 
 41. Reservations. Lessor reserves the right: (i) to grant,
without the consent or joinder of Lessee, such easements, rights and dedications that Lessor deems necessary, (ii) to cause the recordation of parcel maps and restrictions, and (iii) to create and/or install new utility raceways, so long
as such easements, rights, dedications, maps, restrictions, and utility raceways do not unreasonably interfere with the use of the Premises by Lessee. Lessee agrees to sign any documents reasonably requested by Lessor to effectuate such rights.

  

									
		 		  		  		  	
	 	 		  		  		  	 
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 42. Performance Under Protest. If at any time a dispute shall arise as to any amount or sum of
money to be paid by one Party to the other under the provisions hereof, the Party against whom the obligation to pay the money is asserted shall have the right to make payment “under protest” and such payment shall not be regarded as a
voluntary payment and there shall survive the right on the part of said Party to institute suit for recovery of such sum. If it shall be adjudged that there was no legal obligation on the part of said Party to pay such sum or any part thereof, said
Party shall be entitled to recover such sum or so much thereof as it was not legally required to pay. 
 43. Authority. If either
Party hereto is a corporation, trust, limited liability company, partnership, or similar entity, each individual executing this Lease on behalf of such entity represents and warrants that he or she is duly authorized to execute and deliver this
Lease on its behalf. Each party shall, within 30 days after request, deliver to the other Party satisfactory evidence of such authority. 

44. Conflict. Any conflict between the printed provisions of this Lease and the typewritten or handwritten provisions shall be controlled by
the typewritten or handwritten provisions. 
 45. Offer. Preparation of this Lease by either party or their agent and submission of
same to the other Party shall not be deemed an offer to lease to the other Party. This Lease is not intended to be binding until executed and delivered by all Parties hereto. 

46. Amendments. This Lease may be modified only in writing, signed by the Parties in interest at the time of the modification. As long as
they do not materially change Lessee’s obligations hereunder, Lessee agrees to make such reasonable non-monetary modifications to this Lease as may be reasonably required by a Lender in connection with the obtaining of normal financing or
refinancing of the Premises. 
 47. Multiple Parties. If more than one person or entity is named herein as either Lessor or Lessee,
such multiple Parties shall have joint and several responsibility to comply with the terms of this Lease. 
 48. Waiver of Jury Trial.
The Parties hereby waive their respective rights to trial by jury in any action or proceeding involving the Property or arising out of this Agreement. 

49. Mediation and Arbitration of Disputes. An Addendum requiring the Mediation and/or the Arbitration of all disputes between the Parties
and/or Brokers arising out of this Lease  ̈ is
þ is not attached to this Lease. 

50. Rental Escalations: The Base Rent shall: 
  

	 	 (a)
	 be waived during the Early Possession, 

  

	 	 (b)
	 be discounted to $4,874.52 from $9,749.04 from the Commencement Date through 2/28/05, 

 

	 	 (c)
	 go to $9,749.04 on March 1, 2005, and 

  

	 	 (d)
	 increase to $10,139.00 on September 1, 2005. 

51. California Broker Disclosure: Chris Loughridge is a licensed California Real Estate Broker. 

52. Monthly Common Area Operating Expense Estimate: In addition to the Base Rent; Lessee shall initially pay a monthly charge of $1,450.00 which is
an estimate of the monthly Common Area Operating Expenses due under Paragraph #4. 
 53. Right to Recapture: Lessor shall have the option,
at Lessor’s sole discretion, to terminate the lease and recapture the space in lieu of approving any proposed sublease other than the sublease to Perlan. 

54. Assignment/Subleasing Overage: In the event Lessee assigns this lease, or subleases any portion of the premises for more consideration than
that paid by Lessee, seventy-five percent (75%) of any such overage shall be paid to Lessor as additional rent (except in the instance of a sublease to Perlan in which case 100% of the consideration paid by Perlan will be paid to Lessor). If
excess rent is being determined for a subtenant(s) which occupy(ies) less than all of the premises, then excess rent shall be the difference between; (1) the amount of the rent and other amounts paid by the subtenant, and (2) the amount of
base rent and other charges due under the lease multiplied by a fraction, the numerator of which is the usable floor area of the premises occupied by the subtenant(s) and the denominator of which is the total usable floor area of the premises.

 55. Substances For Biomedical Research: Lessor acknowledges that Lessee is in the business of biomedical research. In the course of
conducting such business, Lessee will have on the Premises and will be handling substances that will include, but not be limited to, certain chemicals, gases, solvents, and other materials typically used in biomedical research. Lessee shall abide
by, and be in compliance with all City, State, and Federal Agency rules and regulations governing the usage of said substances. 
 56.
Phase I Environmental Report: At the end of the Lease, Lessee shall provide Lessor with a Phase I Report (or a more detailed report if recommended by the preparer), prepared by a reputable environmental company approved in advance in writing by
Lessor, indicating the Premises is free of any and all Hazardous Materials. 
 57. Lessee’s Financials: Lessee shall deliver a copy
of Lessee’s financial statements to Lessor on a quarterly basis, and a copy of Lessee’s tax return when requested by Lessor. 

58. Animals: Provided it does not create any health risks, odors, or nuisance to any other tenants in the project; and provided Lessee’s use
and housing of all such animals is in compliance with all applicable City, State, and Federal Agency rules and regulations; Lessee may house mice, rats, guinea pigs, and rabbits in hepa filtered cages. 

59. Concession Recapture: If the Lease is terminated prior to the expiration of the Original Term as a consequence of Lessee’s Breach, then,
in addition to all other remedies available to Lessor as a consequence of such Breach, Lessor shall be entitled to recover from Lessee the full amount of any Leasing Commissions paid, or financial concessions made as a part of this Lease including,
but not limited to any Early Possession, Abated Rent, Free Rent, Tenant Improvement Costs, and any Tenant Improvement Allowance. 
 60.
Approval by Lender: The obligations of Lessor under the Lease are conditioned upon written approval of the Lease by Lessor’s Lender(s). 

61. Tenant Improvements: Lessor will install one additional 220 plug if required, but otherwise the Premises is being delivered “AS-IS”.

 62. Option to Expand or Terminate: Lessee shall have a one time option to terminate this Lease if Lessee gives Lessor Notice that
Lessee needs more space, and Lessor is unable to provide suite #101 at 6310 Nancy Ridge Drive (or space of equal or greater size and substantially similar in lab offerings) to Lessee at the same per square foot price within ninety days of said
Notice from Lessee to Lessor. If Lessor is unable to meet Lessee’s space requirement within the ninety day period, Lessee may terminate the lease effective the earlier of (a) 120 days from Lessee’s initial Notice for more space, or
(b) August 31, 2005, by reimbursing Lessor for all unamortized leasing commission, tenant improvements and rent concessions (including Early Possession, Discounted Rent and Free rent). This Option to Expand or Terminate shall expire on the
earlier of (a) August 31, 2005 or (b) any Lessee Default (whether since cured or not). 
 63. Options to Extend: Provided, and
only if, (a) Lessee has not at any time Defaulted (whether since cured or not) under any of the terms of this Lease, and (b) Lessee has delivered written Notice of Lessee’s intent to exercise said option not less than 120 days, prior
to the Expiration Date, Lessee shall have two (2) one (1) year options to extend the Lease at a four 
  

									
		 		  		  		  	
	 	 		  		  		  	 
	 Initials    
	 		  		  		  	    Initials
			
	 ©1999 – American Industrial Real Estate Association
	  	 PAGE 12 OF 14

REVISED
	  	FORM MTN-2-2/99E

 
percent (4%) increase in the Base Rent. 
 64. Existing Equipment: The existing
hoods, ice maker and DI water system are Lessor’s property but may be used by Lessee and shall be maintained in good working order by Lessee at Lessee’s sole cost, during the term of the Lease. 

65. Business Interruption: Lessee acknowledges that, notwithstanding Lessor’s agreement not to require Lessee to maintain business
interruption insurance, the provisions of Paragraph 8.8 of this Lease remain in full force and effect. 
 66. Permitted Transactions:
Lessor’s consent shall not be required for an assignment of this Lease (i) to any person(s) or entity that controls, is controlled by, or is under common control with Lessee, (ii) to any entity resulting from the merger, acquisition,
consolidation, or other reorganization with Lessee, whether or not Lessee is the surviving entity, (iii) to any person or legal entity that acquires all or substantially all of the assets or stock of Lessee (each of the foregoing is hereinafter
referred to as a “Tenant Affiliate”), provided that before such assignment shall be effective, (x) the Tenant Affiliate shall deliver to Lessor a written document by which the Tenant Affiliate assumes in full the obligations of Lessee
under this Lease, (y) Lessor shall be given written notice of such assignment and assumption, including a copy of the document(s) that evidence the assignment, and (z) the use of the Premises by the Tenant Affiliate shall be as set forth
in Paragraph 1.8 above. Lessor’s consent shall also not be required for an assignment described in Paragraph 12(b) above (i.e, sale of 25 percent or more of voting control of Lessee), provided that before such assignment shall be effective, the
person or entity acquiring the voting control executes and delivers to Lessor a written guaranty of Lessee’s obligations under this Lease, and such written guaranty shall be on the current form published by American Industrial Real Estate
Association. Lessor agrees that Paragraph 12.1(b) above shall not apply to sales of shares or other ownership interests of Lessee if such sales are conducted through a nationally recognized securities exchange pursuant to a duly registered
public offering, provided that if more than 25 percent of the voting control of Lessee is sold to a single person or entity, the provisions of the preceding sentence shall apply of Lessor’s consent shall be required. The term
“control” means possession, directly or indirectly, of the power to direct or cause the direction of the management, affairs, and policies of anyone, whether through ownership of voting securities, by contract, or otherwise. The bonus
rental provisions of Section 54 or such other sections shall not apply to an assignment or sublease by Lessee to a Tenant Affiliate. 

% 
 LESSOR AND LESSEE HAVE
CAREFULLY READ AND REVIEWED THIS LEASE AND EACH TERM AND PROVISION CONTAINED HEREIN, AND BY THE EXECUTION OF THIS LEASE SHOW THEIR INFORMED AND VOLUNTARY CONSENT THERETO. THE PARTIES HEREBY AGREE THAT, AT THE TIME THIS LEASE IS EXECUTED, THE TERMS
OF THIS LEASE ARE COMMERCIALLY REASONABLE AND EFFECTUATE THE INTENT AND PURPOSE OF LESSOR AND LESSEE WITH RESPECT TO THE PREMISES. 

ATTENTION: NO REPRESENTATION OR RECOMMENDATION IS MADE BY THE AMERICAN INDUSTRIAL REAL ESTATE ASSOCIATION OR BY ANY BROKER AS TO THE LEGAL
SUFFICIENCY, LEGAL EFFECT, OR TAX CONSEQUENCES OF THIS LEASE OR THE TRANSACTION TO WHICH IT RELATES. THE PARTIES ARE URGED TO: 

1. SEEK ADVICE OF COUNSEL AS TO THE LEGAL AND TAX CONSEQUENCES OF THIS LEASE. 

2. RETAIN APPROPRIATE CONSULTANTS TO REVIEW AND INVESTIGATE THE CONDITION OF THE PREMISES. SAID INVESTIGATION SHOULD INCLUDE BUT NOT BE LIMITED
TO: THE POSSIBLE PRESENCE OF HAZARDOUS SUBSTANCES, THE ZONING OF THE PREMISES, THE STRUCTURAL INTEGRITY, THE CONDITION OF THE ROOF AND OPERATING SYSTEMS, COMPLIANCE WITH THE AMERICANS WITH DISABILITIES ACT AND THE SUITABILITY OF THE PREMISES FOR
LESSEE’S INTENDED USE. 
 WARNING: IF THE PREMISES ARE LOCATED IN A STATE OTHER THAN CALIFORNIA, CERTAIN PROVISIONS OF THE
LEASE MAY NEED TO BE REVISED TO COMPLY WITH THE LAWS OF THE STATE IN WHICH THE PREMISES ARE LOCATED. 
 The parties hereto have
executed this Lease at the place and on the dates specified above their respective signatures. 

 

			
	 Executed at:
	 	 San Diego

			
	 On:
	 	 9/8/04

			
	
	 By LESSOR

	
	 Nancy Ridge Technology Center, L.P., a

	 a California Limited
Partnership

			
		
	 By:
	 	 Nancy Ridge Technology Center, LLC,

	 a California Limited Liability
Co.

			
	 Title:
	 	 General Partner of the
L.P.

			
		
	 By:
	 	 /s/ Chris Loughridge

			
	 Name Printed:
	 	 Chris Loughridge

			
	 Title:
	 	 Manager of the LLC

			
	 Address:
	 	 1145 Pacific Beach Drive #309

	 San Diego, CA 92109-5158

	  

			
	 Telephone:
	 	 (858) 272-4400

			
	 Facsimile:
	 	 (858)272-4600

			
	 Federal ID No.
	 	 33-0990420

 

			
	 Executed at:
	 	 San Diego

			
	 On:
	 	  

			
	
	 By LESSEE

	
	 RexC Pharmaceuticals, Inc., a California

	 corporation

			
		
	 By:
	 	 /s/ John Finn

			
	 Name Printed:
	 	 John Finn

			
	 Title:
	 	 President

			
		
	 By:
	 	  

			
	 Name Printed:
	 	  

			
	 Title:
	 	  

			
	 Address:
	 	  

	  

	  

			
	 Telephone:
	 	 (858)

			
	 Facsimile:
	 	 (858)

			
	 Federal ID No.
	 	
 

 
 These forms are often modified to meet changing requirements of law and
needs of the industry. Always write or call to make sure you are utilizing the most current form: American Industrial Real Estate Corporation, 700 South Flower Street, Suite 600, Los Angeles, CA 90017. 

(213) 687-8777. 

©Copyright 1999 By American Industrial Real Estate Association. 

All rights reserved. 
  

									
		 		  		  		  	
	 	 		  		  		  	 
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	 		  		  		  	    Initials
			
	 ©1999 – American Industrial Real Estate Association
	  	 PAGE 13 OF 14

REVISED
	  	FORM MTN-2-2/99E

 No part of these works may be reproduced in any form without permission in writing. 

 

									
		 		  		  		  	
	 	 		  		  		  	 
	 Initials    
	 		  		  		  	    Initials
			
	 ©1999 – American Industrial Real Estate Association
	  	 PAGE 14 OF 14

REVISED
	  	FORM MTN-2-2/99E

 RULES AND REGULATIONS 

Exhibit “A” 

Attached to and Forming a Part of the Lease Agreement 
  

	 1.
	 Lessor agrees to furnish two keys without charge. Additional keys will be furnished at an optional charge. Lessee shall not change locks or install additional
locks on doors without prior written consent of Lessor. Lessee shall not make or cause to be made duplicates of keys procured from Lessor without prior approval of Lessor. All keys to Leased Premises shall be surrendered to Lessor upon termination
of this Lease. 

  

	 2.
	 Lessee will refer all contractors, contractor’s representatives, and installation technicians rendering any service on or to the Lease Premises for
Lessee to Lessor for Lessor’s approval before performance of any contractual service. Lessee’s contractors and installation technicians shall comply with Lessor’s rules, regulations and specifications pertaining to construction and
installation. This provision shall apply to all work performed on or about the Leased Premises or Property, including installation of telephones, telegraph equipment, electrical devices and attachments and installations of any nature affecting
floors, walls woodwork, trim, windows, ceilings and equipment or any other physical portion of the Lease Premises or Property. 

  

	 3.
	 Lessee shall not at any time occupy any part of the Leased Premises or Property as sleeping or lodging quarters. 

 

	 4.
	 No storage shall be permitted outside the Leased Premises, including, without limitation, the storage of motor vehicles, trucks, boats, trailers. pallets,
drums, or equipment of any kind or nature, without the permission in writing from Lessor. Lessee shall not be permitted to conduct any work activity outside the Leased Premises. Lessee shall not work on motor vehicles on or in the Premises.

  

	 5.
	 Lessee shall not place, install or operate on the Leased Premises or in any part of the Building any engine, stove or machinery, or conduct mechanical
operations or cook thereon or therein, or place or use in or about the Leased Premises or Property any explosives, gasoline, kerosene, oil, acids, caustics, or any flammable, explosive or hazardous material without written consent of Lessor. Lessee
shall not use, keep or permit to be used or kept any foul or obnoxious gas or substance on or around the Premises, which would unreasonably disturb other tenants on the Project or is prohibited by a standard form insurance policy. Notwithstanding
the foregoing, this rule shall not be construed to preclude Lessee’s use of a microwave oven or similar appliances in an employee break room. 

  

	 6.
	 Lessor will not be responsible for lost or stolen personal property, equipment, money or jewelry from the Leased Premises or the Property regardless or
whether such loss occurs when the area is locked against entry. 

  

	 7.
	 No dogs, cats, fowl or other animals shall be brought into or kept in or about the Leased Premises or Property. 

 

	 8.
	 None of the parking, lawn areas, entries, doors or stairways shall be blocked or obstructed or any rubbish, litter, trash, or material or any nature placed,
emptied or thrown into these areas or such area used by Lessee’s agents, employees or invitees at any time for purposes inconsistent with their designation by Lessor. No Lessee shall permit any trash, oil, chemicals or any foreign materials to
be deposited or disposed of in the landscaped, parking or common areas of the project. Trash (not including oil, hazardous materials, chemicals, which shall not be disposed of on the project) shall be placed inside the bins. at a level not higher
than the top of the bin and shall not be placed outside the bin or in the enclosure area. Lessee shall cooperate with Lessor and all other tenants of the development so that the common areas may be kept in a clean and orderly condition and free of
obstruction. Lessor provides free, NORMAL use of waste containers and disposal service; however, Lessee shall provide, at Lessee’s expense, waste containers and regular disposal service as may be, required by Lessee in excess of the service
made available by Lessor as provided above. This shall preclude abnormal trash pick-ups as determined by Lessor where trash generated by Lessee is considered excessive above average usage. 

 

	 9.
	 The water closets and other water fixtures shall not be used for any purpose other than those for which they were constructed, and any damage resulting to
them from misuse or by the defacing or injury of any part of the building shall be borne by the person who shall occasion it. No person shall waste water by interfering with the faucets or otherwise. 

 

	 10.
	 No person shall disturb occupants of the Building by the use of any radios, record players, tape recorders, musical instruments, the making of unseemly noises
or any unreasonable use. 

	 11.
	 Subject to the term of the Lease, no advertisement, picture or sign of any sort shall be displayed on or outside the Premises without the prior written
consent of the Lessor. Lessor shall have the right to remove any such unapproved item without notice and at Lessee’s expense. 

  

	 12.
	 Lessee shall not use any method of heating or air conditioning other than that supplied by Landlord without the consent of Lessor.

  

	 13.
	 Lessee shall not disturb, solicit or canvas any occupant of the Building or Project and shall cooperate to prevent the same. 

 

	 14.
	 No persons shall go on the roof or in the meter rooms(s) without the Landlord’s permission. 

 

	 15.
	 Business machines and mechanical equipment belonging to the Lessee which cause noise or vibration that may be transmitted to the structure of the Building, to
such a degree as to cause structural damages or unreasonably disturb other tenants shall be placed and maintained by Lessee, at Lessee’s expense, on vibration eliminators or other devices sufficient to effectively control noise vibration.

  

	 16.
	 Except in the normal conduct of its business, Lessee shall not regularly park motor vehicles in the parking areas after the conclusion of normal daily
business activities. 

 Lessee and its employees, agents and invitees shall park their vehicles only in
those parking areas designated by Lessor. Lessee shall not leave any vehicle in a state of disrepair (including without limitation, flat tires, out of date inspection stickers, or license plates) on the Property. If Lessee or its employees, agents,
invitees park their vehicles in areas other than the designated parking areas or leave any vehicle in a state of disrepair, Lessor shall have the right to remove such vehicles at Lessee’s expense. Parking is shared in common with all other
tenants. 
 Parking shall be in compliance with all parking rules and regulations including any sticker or other
identification system established by Lessor. Failure to observe the rules and regulations shall terminate Lessee’s right to use the parking area and subject the vehicle in violation of the parking rules and regulations to removal and
impoundment. No such termination of parking privileges or removal of impoundment of a vehicle shall create any liability on Lessor or to be deemed to interfere with Lessee’s right to possession of the Leased Premises. Vehicles must be parked
entirely within the stall lines and all directional signs, arrows and posted speed limits must be observed. Parking is prohibited in areas not striped for parking, in aisles, where “No Parking” signs are posted, on ramps, in crosshatched
areas, and in other areas as may be designated by Lessor. Parking stickers or other forms or identification supplied by Lessor shall remain the property of Lessor and not the property of Lessee and are not transferable. Every person is required to
park and lock his vehicle. All responsibility for damage to vehicles or persons is assumed by the owner of the vehicle or its driver. 

Lessee shall unload vehicles only in those areas designated by Lessor for such purpose. During periods of loading and unloading,
Lessee shall not unreasonably interfere with traffic flow within the project and loading and unloading areas of other tenants. All goods, including materials used to store goods, delivered to the premises of the Lessee shall be immediately moved
into premises and shall not be left in parking or receiving areas overnight. Tractor-trailers, which must be unhooked or parked with dolly wheels beyond the concrete loading areas, must use steel plates or wood blocks under the dolly wheels to
prevent damage to the asphalt paving surfaces. No parking or storing of such trailers will be permitted in the auto parking areas of the Project or on streets adjacent thereto. 

 

	 17.
	 Lessee is responsible for the cleaning of his own entry, restrooms and interior of windows. In the case of shared entries, hallways and restrooms, each Lessee
shall cooperate with the other Tenants sharing the facilities to maintain good order and shall share the expense equally. 

  

	 18.
	 Lessee will provide and keep in working order all necessary fire extinguishers to provide adequate protection and meet all city, state and federal
requirements. 

  

	 19.
	 Lessee shall not lay floor covering within the Lease Premises without written approval of the Lessor. The use of cement or other similar adhesive materials
not easily removed with water is expressly prohibited. 

  

	 20.
	 No stored goods (e.g. boxes, racking, raw or finish product, etc.) shall be visible through Lessee’s windows. Lessee shall use window coverings that are
acceptable to Lessor to prevent any such items from being visible through the windows to the outside. It shall be Lessee’s responsibility to maintain the window coverings in good working order and condition so as to maintain the aesthetic
appeal of the property. 

	 21.
	 It is Lessor’s desire to maintain the Property in the highest standard of dignity and good taste consistent with comfort and convenience for Lessees. Any
action or condition not meeting this high standard should be reported directly to Lessor. Your cooperation will be mutually beneficial and sincerely appreciated. Lessor reserves the right to make such other and further reasonable rules and
regulations that in its judgement may from time to time be necessary, for the safety, care and cleanliness of the Leased Premises and for the preservation of good order therein. 

 

	 22.
	 Smoking of cigarettes, pipes or cigars is not permitted in the Premises. 

 

													
	 “LESSEE”
	  		  		  		  	
							
		  	 By:
	  	 /s/ John Finn
	  		  	 Date:
	  	 Sept 8, 2004
	  	

 

 

 

 

 

 

 

 

 FIRST AMENDMENT DATED AUGUST 2, 2006 

Nancy Ridge Technology Center, L.P., a California limited partnership (“Lessor”), and Rx3 Pharmaceuticals, Inc. (formerly
known as RexC Pharmaceuticals, Inc.), a California Corporation (“Lessee”) hereby amend the Lease dated September 7, 2004 for suite #105 at 6310 Nancy Ridge Drive, San Diego, CA 92121 (“Premises”) as follows effective
August 1, 2006: 
  

	 1.
	 Premises: Lessee shall expand into the portion of suite #102 at 6310 Nancy Ridge Drive formerly occupied by Perlan, which:

 (1) excludes rooms #107 and #200 thru #204, all of which are exclusively used by Genpathway,

 (2) includes rooms #101 thru #104, and room #108, all of which shall be exclusively used by Lessee, and 

(3) includes the rooms and areas in suite #102 not listed above which shall be considered Suite #102 common areas that may be used
on a non-exclusive basis, and in which Genpathway and Lessee may not place or store any Personal Property. 
 (4)
represents approximately 2,678 square feet of additional space. 
 The Premises shall increase to approximately 8,481
square feet, and Lesee’s Share shall increase to approximately four point eight three percent (4.83%). 
  

	 2.
	 Base Rent: The Base Rent shall increase to $15,410.72 per month on September 1, 2006. 

 

	 3.
	 Suite #102 Utilities: The Suite #102 utilities shall be pro-rated by footage occupied by Lessee and Genpathway in Suite #102. If the lease with
Genpathway terminates or expires, Lessee shall pay the entire utility cost for all of suite #102 until new tenant(s) occupy the space. Once the remainder of suite #102 is occupied by new tenant(s), the utilities shall again be pro-rated by footage
occupied by Lesse and new tenant(s). In light of the new hoods Lessee will be installing in the space, Lessor shall have the right, at Lessor’s sole discretion, to change the manner in which the utilities are pro-rated once Lessor has more
information on Genpathway’s historical usage. 

  

	 4.
	 Exercise of First Option to Extend: Lessee has exercised the first of its two Options to Extend under paragraph #63. The Expiration Date shall be
August 31, 2007 instead of August 31, 2006. 

  

	 5.
	 Tenant Improvements: Lessee shall, at Lessee’s sole cost, install stainless ducts and fans, and upgrade the airconditioning capacity, to support
three eight foot chemistry hoods in the Premises. Lessor shall contribute the lesser of (a) $5,000 or (b) one half of the cost of such work. Lessor shall have the first right of refusal to purchase the fume hoods if Lessee vacates the
Premises and elects to sell or donate the fume hoods. Lessor shall have three (3) business days from receipt of Notice and a bona fide offer from Lessee to decide whether to purchase the hoods. 

 

	 6.
	 Confidentiality: The terms of the Lease are confidential. No party to the Lease, nor any broker, shall disclose any of the terms of the Lease to any
other party. 

  

	 7.
	 No Lessor Default: Lessor is not currently in Default of any of the terms or conditions of the Lease 

 

	 8.
	 Brokers: Lessor and Lessee each represent to the other that they have dealt with no real estate agents, brokers, finders, or salesmen in connection
with this transaction. Each party agrees to hold the other party harmless from and against all claims for brokerage commissions, finder’s fees or other compensation made by any agent, broker, finder or salesman as a consequence of said
party’s actions or dealings with such agent, broker, finder or salesman. 

  

	 9.
	 Authority to Execute: Each person executing this Amendment represents and warrants to all parties that he or she is duly authorized to execute and
deliver this Amendment on behalf of that party. 

 All other terms and conditions of the original Lease shall remain in
full force and effect. 
 In witness hereof, the parties have caused these present to be executed as of the day and the year first above
written. 

							
	 Lessor:
	  	 Nancy Ridge Technology Center, L.P., a California Limited Partnership

	 By:
	  	 Nancy Ridge Technology Center, L.L.C., a California Limited Liability Company, General
Partner

			
		
	 By:
	 	 /s/ Chris Loughridge

		 	 Chris Loughridge, its Manager

					
			
	 Date:
	 	 8/7/06
	 	

			
		
	 Lessee:
	  	 Rx3 Pharmaceuticals, Inc., a California Corporation

			
		
	 By:
	 	 /s/ John Schmid

			
		
	 Title:
	 	 CFO

					
			
	 Date:
	 	 8/3/06
	 	

 SECOND AMENDMENT DATED MARCH 14, 2007 

Nancy Ridge Technology Center, L.P., a California limited partnership (“Lessor”), and Trius Therapeutics, Inc., a California corporation,
(“Lessee”) as successor in interest to (a) RexC Pharmaceuticals, and (b) RX3, hereby amend the Lease dated September 7, 2004 for suite #105 at 6310 Nancy Ridge Drive, San Diego, CA 92121 (“Premises”) as follows:

 1) Premises: Lessee shall vacate suite #102 at 6310 Nancy Ridge Drive on or before April 30, 2007 and may immediately take
Early Possession of suite #101 at 6310 Nancy Ridge Drive. Effective May 1, 2007, the Premises shall be suites #101 & #105 at 6310 Nancy Ridge Drive, which combined are approximately 13,121 square feet, and Lesee’s Share shall be
approximately seven point five percent (7.5%). 
 2) Base Rent: The Base Rent shall increase to $22,912 per month on May 1,
2007, and then increase four percent (4%) on every twelve (12) month anniversary of the Commencement Date of the Original Term. 

3) Lease Term: The Lease Term is hereby extended. The Expiration Date shall be January 31, 2008 instead of August 31, 2007.

 4) Option to Extend: Lessee has exercised the first of its two Options to Extend under paragraph #63. Lessee has one
(1) remaining one (1) year Option to Extend. 
 5) Confidentiality: The terms of the Lease are confidential. No party to
the Lease, nor any broker, shall disclose any of the terms of the Lease to any other party. 
 6) No Lessor Default: Lessor is not
currently in Default of any of the terms or conditions of the Lease 
 7) Authority to Execute: Each person executing this
Amendment represents and warrants to all parties that he or she is duly authorized to execute and deliver this Amendment on behalf of that party. 

All other terms and conditions of the original Lease shall remain in full force and effect. 

In witness hereof, the parties have caused these present to be executed as of the day and the year first above written. 

 

			
	 Lessor:
	  	 Nancy Ridge Technology Center, L.P., a California Limited Partnership

	 By:
	  	 Nancy Ridge Technology Center, L.L.C., a California Limited Liability Company, General
Partner

			
		
	 By:
	 	 /s/ Chris Loughridge

		 	 Chris Loughridge, its Manager

			
		
	 Date:
	 	
3/31/07

			
		
	 Lessee:
	  	 Trius Therapeutics, Inc., a California Corporation

			
		
	 By:
	 	 /s/ John Schmid

			
		
	 Title:
	 	 CFO

			
		
	 Date:
	 	 3-29-07

 

 1. 

 THIRD AMENDMENT DATED SEPTEMBER 24, 2007 

Nancy Ridge Technology Center, L.P., a California limited partnership (“Lessor”), and Trius Therapeutics, Inc., a California corporation,
(“Lessee”), hereby amend the Lease dated September 7, 2004 for suites #101 & #105 at 6310 Nancy Ridge Drive, San Diego, CA 92121 (“Premises”) as follows: 

1) Lease Term: The Lease Term is hereby extended. The Expiration Date shall be January 31, 2009 instead of January 31, 2008.

 2) Option to Extend: Lessee has exercised the first of its two Options to Extend under paragraph #63. Lessee has one (1)
remaining one (1) year Option to Extend. 
 3) Confidentiality: The terms of the Lease are confidential. No party to the
Lease, nor any broker, shall disclose any of the terms of the Lease to any other party. 
 4) No Lessor Default: Lessor is not
currently in Default of any of the terms or conditions of the Lease. 
 5) Authority to Execute: Each person executing this
Amendment represents and warrants to all parties that he or she is duly authorized to execute and deliver this Amendment on behalf of that party. 

All other terms and conditions of the original Lease shall remain in full force and effect. 

In witness hereof, the parties have caused these present to be executed as of the day and the year first above written. 

 

			
	 Lessor:
	  	 Nancy Ridge Technology Center, L.P., a California Limited Partnership

	 By:
	  	 Nancy Ridge Technology Center, L.L.C., a California Limited Liability Company, General
Partner

			
		
	 By:
	 	 /s/ Chris Loughridge

		 	 Chris Loughridge, its Manager

			
		
	 Date:
	 	
10/12/07

 

			
	 Lessee:
	  	 Trius Therapeutics, Inc., a Delaware Corporation

			
		
	 By:
	 	 /s/ John Schmid

			
		
	 Title:
	 	 CFO

			
		
	 Date:
	 	 9/27/07

 

 FOURTH AMENDMENT DATED MAY 12, 2008 

Nancy Ridge Technology Center, L.P., a California limited partnership (“Lessor”), and Trius Therapeutics, Inc., a Delaware corporation,
(“Lessee”), hereby amend the Lease dated September 7, 2004 for Suites #101 & #105 at 6310 Nancy Ridge Drive, San Diego, CA 92121 (“Premises”) as follows effective July 15, 2008: 

1) Premises: The Premises shall be expanded to include Suite #106 at 6310 Nancy Ridge Drive, for a total of approximately 18,924 square
feet. Lessee’s Share shall be ten point eight one percent (10.81%). 
 2) Lease Term: The Lease Term is hereby extended. The
Expiration Date shall be January 31, 2010 instead of January 31, 2009. 
 3) Tenant Improvements: Lessor shall, at
Lessor’s sole cost, do the following in suite #102 
  

	 	 (a)
	 clean the carpet & tile flooring 

  

	 	 (b)
	 touch up paint as needed 

  

	 	 (c)
	 repair any damaged bench edges 

  

	 	 (d)
	 rebuild room #619, and restore the openings between rooms #515 & #618, #513 & #613, and in #502 per the attached

 Other than the above, the Premises is being delivered in “as-is” condition. 

4) Base Rent: The Base Rent shall increase to $34,367.06 per month, and then four percent (4%) on every twelve (12) month
anniversary of the Commencement Date of the Original Term. 
 5) Exercise of
2nd Option to Extend: Lessee has
exercised the second of its two Options to Extend under paragraph #63. There are no remaining Options to Extend. 
 6)
Confidentiality: The terms of the Lease are confidential. No party to the Lease, nor any broker, shall disclose any of the terms of the Lease to any other party. 

7) No Lessor Default: Lessor is not currently in Default of any of the terms or conditions of the Lease 

8) Authority to Execute: Each person executing this Amendment represents and warrants to all parties that he or she is duly authorized to
execute and deliver this Amendment on behalf of that party. 
 All other terms and conditions of the original Lease shall remain in full
force and effect. 
 In witness hereof, the parties have caused these present to be executed as of the day and the year first above
written. 
  

			
	 Lessor:
	  	 Nancy Ridge Technology Center, L.P., a California Limited Partnership

	 By:
	  	 Nancy Ridge Technology Center, L.L.C., a California Limited Liability Company, General
Partner

			
		
	 By:
	 	 /s/ Chris
Loughridge

			
		 	 Chris Loughridge, its Manager

		
	 Date:
	 	
6/18/08

 

			
	 Lessee:
	  	 Trius Therapeutics, Inc., a Delaware Corporation

			
		
	 By:
	 	 /s/ John Schmid

			
		
	 Title:
	 	 CFO

			
		
	 Date:
	 	 5-27-08

 

 

 

 

 

 FIFTH AMENDMENT DATED MARCH 11, 2010 

Nancy Ridge Technology Center, L.P., a California limited partnership (“Lessor”), and Trius Therapeutics, Inc., a Delaware corporation,
(“Lessee”), hereby amend the Lease dated September 7, 2004 for Suites #101, 105 & 106 at 6310 Nancy Ridge Drive, San Diego, CA 92121 (“Premises”): 

 

	1.	 	Premises & Lessee’s Share: The Premises shall be expanded to include Suite #104 at 6310 Nancy Ridge Drive (which is approximately 4,850 square
feet) for a total of approximately 23,774 square feet. Lessee’s Share shall increase to thirteen point five nine (13.59%). 

  

	2.	 	Lease Term: The Lease Term is hereby extended. The Expiration Date shall be December 31, 2010 instead of January 31, 2010. 

 

	3.	 	Base Rent: The Base Rent shall decrease to $35,741.74 effective March 1, 2010. The Base Rent shall increase four percent (4%) every twelve
(12) months thereafter. 

  

	4.	 	Option to Extend / Free Rent: Lessee shall have the right to extend the Lease Term for: 

 

	 	(i)	 	one (1) year (to December 31, 2011), OR 

  

	 	(ii)	 	two (2) years (to December 31, 2012), and receive one (1) months of free rent (Base Rent only for January of 2011), OR 

 

	 	(iii)	 	three (3) years (to December 31, 2013), and receive two (2) months of free rent (Base Rent only for January and February of 2011)

 To exercise this option, Lessee must deliver Notice to Lessor of Lessee’s exercise said option, specifying Lessee’s
choice of the three options below, on or before September 30, 2010. This option shall expire if not exercised by Lessee on or before September 30, 2010. 
  

	5.	 	Confidentiality: The terms of the Lease are confidential. No party to the Lease, nor any broker, shall disclose any of the terms of the Lease to any other party.

  

	6.	 	No Lessor Default: Lessor is not currently in Default of any of the terms or conditions of the Lease. 

 

	7.	 	Authority to Execute: Each person executing this Amendment represents and warrants to all parties that he or she is duly authorized to execute and deliver this
Amendment on behalf of that party. 

 All other terms and conditions of the original Lease shall
remain in full force and effect. 

 In witness hereof, the parties have caused these present to be executed as of the day and the year first
above written. 
  

			
	Lessor:  	 	 Nancy Ridge Technology Center, L.P.,

a California Limited Partnership

		
	By:	 	 Nancy Ridge Technology Center, L.L.C.,

a California Limited Liability Company, General Partner

		
	By:	 	 /s/ Chris Loughridge

		 	Chris Loughridge, its Manager
		
	Date:	 	 March 26, 2010

		
	Lessee:  	 	 Trius Therapeutic Inc.,

a Delaware Corporation

		
	By:	 	 /s/ John P. Schmid

		 	John P. Schmid
		
	Title:	 	 Chief Financial Officer

		
	Date:	 	 March 15, 2010

 

 2Contract Award

 Exhibit 10.16 

***Text Omitted and Filed Separately 

With the Securities and Exchange Commission. 

Confidential Treatment Requested 

Under 17 C.F.R. Sections 200.80(b)(4) 

And Rule 406 of the Securities 

Act of 1933, as amended. 
  

																															
	 	 	 	 	 	 	 	 	PAGE OF PAGES
	AWARD/CONTRACT	 	 1. THIS CONTRACT IS A RATED ORDER

    UNDER DP AS (15 CFR 700)
	 	 	 	RATING 	 	1	 	35
	 2.
CONTRACT (Proc. Inst. Ident.) NO.
 HDTRA1-10-C-0004
	 	 3. EFFECTIVE DATE

            21 Apr 2010
	 	 4. REQUISITION/PURCHASE
REQUEST/PROJECT NO.
 CBM090014890

	5. ISSUED BY	 	CODE  	 		 	  HDTRA1	 	6. ADMINISTERED BY                 (If other than Item 5)	 	CODE        	 	S0514A
	
DEFENSE THREAT REDUCTION AGENCY/BE-BC
 8725 JOHN
J. KINGMAN ROAD, MSC 6201
 FORT BELVOIR VA 22060-6201
	 	 DCMA SAN DIEGO

7675 DAGGET STREET, SUITE 200
 SAN DIEGO CA
92111-2241

	7. NAME AND ADDRESS OF CONTRACTOR (No. street, city, county, name and zip code)	 	8. DELIVERY
	 TRIUS THERAPEUTICS, INC.

JOHN SCHMID
	 		 	 	 	[    ] FOB ORIGIN [X] OTHER (See below)
	6310 NANCY RIDGE DR STE 101	 		 	 	 	9. DISCOUNT FOR PROMPT PAYMENT
	SAN DIEGO CA 92121-3209	 		 	 	 	 Net 30 Days

 

	 	 		 	 	 	 10. SUBMIT INVOICES

(4 copies unless otherwise specified)
 TO
THE ADDRESS
 SHOWN IN:
	 	1  	 	ITEM
	 	 		 		 		 		 		 		 		 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	CODE 47YA5	 	 	 	 	 	FACILITY CODE	 	 	 	 	 
	11. SHIP TO/MARK FOR	 	CODE  	 		 	HDTRA1	 	12. PAYMENT WILL BE MADE BY	 	CODE	 	HQ0339
	 DEFENSE THREAT REDUCTION
AGENCY/RD/CBM
 SEE SEPARATE LETTER

8725 JOHN J. KINGMAN ROAD, MAIL STOP 6201
 FORT
BELVOIR VA 22060
  
	 	 DFAS COLUMBUS CENTER

DFAS-COWEST ENTITLEMENT OPERATIONS
 P.O. BOX
182381
 COLUMBUS OH 43218-2381
  

	 13. AUTHORITY FOR USING OTHER THAN
FULL AND OPEN COMPETITION
 [    ] 10 U.S.C.
2304(c)(        )  [    ] 41 U.S.C. 253(c)(        )
  
	 	 14. ACCOUNTING AND APPROPRIATION
DATA
  
 See Schedule

 

	15A. ITEM NO.	 	15B. SUPPLIES/SERVICES	 	15C. QUANTITY	 	15D. UNIT  	 	    15E. UNIT PRICE	 	 	 	        15F. AMOUNT
	 	 		 	 	 		 		 		 		 	 	 		 		 		 	 
	 	 		 	 	 		 		 		 		 	 	 		 		 		 	 
	 	 		 	 	 	SEE SCHEDULE	 		 		 		 	 	 		 		 		 	 
	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	15G. TOTAL AMOUNT OF CONTRACT 	 	        $6,814,598,.00
EST
	16. TABLE OF
CONTENTS
	(X)  	 	SEC.	 	DESCRIPTION	 	 	 	 	 	 	 	PAGE(S)	 	(X)	 	SEC.	 	DESCRIPTION	 	 	 	PAGE(S)
	PART I – THE
SCHEDULE	 	PART II – CONTRACT CLAUSES
	X	 	A	 	 SOLICITATION/CONTRACT FORM
	 	1	 	X	 	I	 	CONTRACT CLAUSES	 	18 - 35
	X	 	B	 	 SUPPLIES OR SERVICES AND PRICES/COSTS
	 	2 - 4	 	PART III – LIST OF DOCUMENTS, EXHIBITS AND OTHER
ATTACHMENTS
	 	 	C	 	 DESCRIPTION/SPECS/WORK STATEMENT
	 	 	 	 	 	J	 	LIST OF ATTACHMENTS	 	 
	X	 	D	 	 PACKAGING AND MARKING
	 	5	 	PART IV – REPRESENTATIONS AND
INSTRUCTIONS
	X	 	E	 	 INSPECTION AND ACCEPTANCE
	 	6	 	 	 	K	 	REPRESENTATIONS, CERTIFICATIONS AND OTHER STATEMENT OF OFFERORS	 	 
	X	 	F	 	 DELIVERIES OR PERFORMANCE
	 	7	 	 	 	 	 	 
	X	 	G	 	 CONTRACT ADMINISTRATION DATA
	 	8 - 14	 	 	 	L	 	INSTRS. CONDS. AND NOTICES TO OFFERORS	 	 
	X	 	H	 	 SPECIAL CONTRACT REQUIREMENTS
	 	15 -17	 	 	 	M	 	EVALUATION FACTORS FOR AWARD	 	 
	CONTRACTING
OFFICER WILL COMPLETE ITEM 17 OR 18 AS APPLICABLE
	
17. [X] CONTRACTOR’S NEGOTIATED AGREEMENT Contractor is required to sign this document and return] copies to issuing office.) Contractor
agrees to furnish and deliver all items or perform all the services set forth or otherwise indemnified above and on any continuation sheets for the consideration stated herein. The rights and obligations of the parties to this contract shall be
subject to and governed by the following documents. (a) this award contract, (b) the solicitation, if any, and (c) such provisions, representations, certifications, and specifications, as are attached or incorporated by reference
herein
 (Attachments are listed herein.)
	 	 18. [    ]
AWARD (Contractor is not required to sign this document) Your offer on Solicitation Number
                                         
   
  
 including the additions or changes made by you which
additions or changes are set forth in full above, is hereby accepted as to the items listed above and on any continuation sheets. This award consummates the contract which consists of the following documents: (a) the Government’s solicitation
and your offer, and (b) this award/contract. No further contractual document is necessary
  

	
19A. NAME AND TITLE OF SIGNER (Type of print)
  

John P. Schmid, CFO
	 	 20A. NAME OF CONTRACTING OFFICER

                 VICTOR E. CRAMER

                   Contracting
Officer
  
 TEL: (703)
767-8769                                    EMAIL:
VICTOR.CRAMER@DTRA.MIL

	 19B. NAME OF CONTRACTOR

 
 BY /s/ John P. Schmid
	 	 19C. DATE SIGNED

 
 4-16-10
	 	 	 	 20B. UNITED STATES OF AMERICA

 
 BY /s/ Victor E. Cramer

 
	 	 20V. DATE SIGNED

 
 4-19-2010

 HDTRA1-10-C-004 

 Page
 2
 of 35
  

 Section B - Supplies or Services and Prices 

 

												
	 ITEM NO
	  	 SUPPLIES/SERVICES
	  	QUANTITY	  	UNIT	  	UNIT PRICE	  	AMOUNT
	0001	  		  		  	Lot	  		  	$	6,814,598.00
		  	Base	  		  		  		  		
		  	CPFF	  		  		  		  		
		  	In accordance with Statement of Work entitled “Broad Spectrum Antibacterial Therapeutics from Marine Natural products” dated 11/30/2009 as attachment number
1.	  		  		
		  	FOB: Destination	  		  		  		  		
		  	PURCHASE REQUEST NUMBER: CBM090014890	  		  		
		  		  		  		  		  		
		  		  	[...***...]	  		  		  	 	[...***...] 
		  		  	[...***...]	  		  		  	 	[...***...]
		  		  		  		  		  	 	 
		  		  	TOTAL EST COST + FEE	  	$	6,814,598.00 (EST.)
						
	 ITEM NO
	  	 SUPPLIES/SERVICES
	  	QUANTITY	  	UNIT	  	UNIT PRICE	  	AMOUNT
	000101	  		  		  		  		  	$	0.00
		  	Funding	  		  		  		  		
		  	CPFF	  		  		  		  		
		  	FOB: Destination	  		  		  		  		
		  	PURCHASE REQUEST NUMBER: CBM090014890	  		  		  		  		
		  		  	ESTIMATED COST	  		  		  	$	0.00
		  		  	FIXED FEE	  		  		  	$	0.00
		  		  		  		  		  	 	 
		  		  	TOTAL EST COST + FEE	  	$	0.00
		  	ACRN AA	  		  		  		  	$	1,136,766.00
		  	CIN: CBM090014890000101	  		  		  		  		

  

 ***Confidential Treatment Requested 

 HDTRA1-10-C-004 

 Page 
 3
 of 35
  

												
	 ITEM NO
	  	 SUPPLIES/SERVICES
	  	QUANTITY	  	UNIT	  	UNIT PRICE	  	AMOUNT
	000102	  		  		  		  		  	$	0.00
		  	Funding	  		  		  		  		
		  	CPFF	  		  		  		  		
		  	FOB: Destination	  		  		  		  		
		  		  	ESTIMATED COST	  		  		  	$	0.00
		  		  	FIXED FEE	  		  		  	$	0.00
		  		  		  		  		  	 	 
		  		  	TOTAL EST COST + FEE	  		  	$	0.00
		  	 ACRN AB
	  		  		  		  	$	3,028,710.00
		  	 CIN: CBM090014890000102
	  		  		  		  		
						
	 ITEM NO
	  	 SUPPLIES/SERVICES
	  	QUANTITY	  	UNIT	  	UNIT PRICE	  	AMOUNT
	0002	  		  		  	Lot	  		  	$	9,854,156.00
	OPTION	  	Option Period 1	  		  		  		  		
		  	CPFF	  		  		  		  		
		  	FOB: Destination	  		  		  		  		
		  	PURCHASE REQUEST NUMBER: CBM090014890	  		  		  		  		
		  		  	[...***...] 	  		  		  	 	[...***...]
		  		  	[...***...]	  		  		  	 	[...***...]
		  		  		  		  		  	 	 
		  		  	TOTAL EST COST + FEE	  		  	$	9,854,156.00 (EST.)
						
	 ITEM NO
	  	 SUPPLIES/SERVICES
	  	QUANTITY	  	UNIT	  	UNIT PRICE	  	AMOUNT
	0003	  		  		  	Lot	  		  	$	5,058,455.00
	OPTION	  	Option Period 2	  		  		  		  		
		  	CPFF	  		  		  		  		
		  	FOB: Destination	  		  		  		  		
		  	PURCHASE REQUEST NUMBER: CBM090014890	  		  		  		
		  		  	[...***...]	  		  		  	 	[...***...]
		  		  	[...***...]	  		  		  	 	[...***...]
		  		  		  		  		  	 	 
		  		  	TOTAL EST COST + FEE	  		  	$	5,058,455.00 (EST.)

  

 ***Confidential Treatment Requested 

 HDTRA1-10-C-004 

 Page
 4
 of 35
  

												
						
	 ITEM NO
	  	 SUPPLIES/SERVICES
	  	QUANTITY	  	UNIT	  	UNIT PRICE	  	AMOUNT
	0004	  		  		  	Lot	  		  	$	6,823,982.00
	OPTION	  	Option Period 3	  		  		  		  		
		  	CPFF	  		  		  		  		
		  	FOB: Destination	  		  		  		  		
		  	PURCHASE REQUEST NUMBER: CBM090014890	  		  		  		  		
		  		  	[...***...]	  		  		  	 	[...***...]
		  		  	[...***...]	  		  		  	 	[...***...]
		  		  		  		  		  	 	 
		  		  	TOTAL EST COST + FEE	  	$	6,823,982.00 (EST.)
						
	 ITEM NO
	  	 SUPPLIES/SERVICES
	  	QUANTITY	  	UNIT	  	UNIT PRICE	  	AMOUNT
	0005	  		  		  		  		  	$	916,616.00
	OPTION	  	Option Task	  		  		  		  		
		  	CPFF	  		  		  		  		
		  	FOB: Destination	  		  		  		  		
		  	PURCHASE REQUEST NUMBER: CBM090014890	  		  		  		  		
		  		  	[...***...]	  		  		  	 	[...***...]
		  		  	[...***...]	  		  		  	 	[...***...]
		  		  		  		  		  	 	 
		  		  	TOTAL EST COST + FEE	  	$	916,616.00 (EST.)
						
	 ITEM NO
	  	 SUPPLIES/SERVICES
	  	QUANTITY	  	UNIT	  	UNIT PRICE	  	AMOUNT
	0006	  		  		  		  		  	 	NSP
		  	CDRLS	  		  		  		  		
		  	CPFF	  		  		  		  		
		  	FOB: Destination	  		  		  		  		
		  		  	ESTIMATED COST	  	$	0.00
		  		  	FIXED FEE	  		  	$	0.00
		  		  		  		  		  	 	 
		  		  	TOTAL EST COST + FEE	  	$	0.00

  

 ***Confidential Treatment Requested 

 HDTRA1-10-C-004 

 Page
 5
 of 35 
  

 Section D – Packaging and Marking 

CLAUSES INCORPORATED BY FULL TEXT 
 252.247-9001
PACKAGING AND MARKING 
 (a) All data contained in Exhibit A, Contract Data Requirements List (CDRL), DD Form 1423 delivered under this contract
shall be delivered using best commercial practices to meet the packaging requirements of the carrier and to insure delivery, to the addressees specified on the Data Item Cover Sheet, at destination and in accordance with applicable security
requirements. 
 (b) All data and correspondence submitted to the Contracting Officer shall reference the Contract Number, the CDRL number, and
the date submitted. A copy of all correspondence sent to the Contracting Officer’s Representative (COR) or Project Manager shall be simultaneously provided to the Contracting Officer. 

 HDTRA1-10-C-004 

 Page
 6
 of 35 
  

 Section E - Inspection and Acceptance 

INSPECTION AND ACCEPTANCE TERMS 

Supplies/services will be inspected/accepted at: 
  

									
	 CLIN
	  	 INSPECT AT
	  	 INSPECT BY
	  	 ACCEPT AT
	  	 ACCEPT BY

	0001	  	Destination	  	Government	  	Destination	  	Government
	000101	  	Destination	  	Government	  	Destination	  	Government
	000102	  	N/A	  	N/A	  	N/A	  	Government
	0002	  	Destination	  	Government	  	Destination	  	Government
	0003	  	Destination	  	Government	  	Destination	  	Government
	0004	  	Destination	  	Government	  	Destination	  	Government
	0005	  	Destination	  	Government	  	Destination	  	Government
	0006	  	N/A	  	N/A	  	N/A	  	Government

 CLAUSES INCORPORATED BY REFERENCE 

 

							
	52.246-8	 		  	Inspection Of Research And Development Cost Reimbursement	  	 MAY 2001

 CLAUSES
INCORPORATED BY FULL TEXT 
 252.246-9000 INSPECTION AND ACCEPTANCE (JUL 2007) 

Government inspection and acceptance of data is specified on the Contract Data Requirements List, DD Form 1423. In accordance with FAR 52.246-8,
inspection and acceptance for all work performed at any and all times under this contract shall be the responsibility of the: 
 X Contracting
Officer’s Representative (COR) or Project Manager (PM). The Wide Area Work Flow (WAWF) Acceptor DoDDAC is located in DTRA 252.201-9000 Project Manager or DTRA 252.201-9002 Contracting Officer’s Representative. 

             Administrative Contracting Officer (ACO). The WAWF Acceptor DoDAAC can be
found in the “Administered By” block on page 1 of the contract. 
 (End of Clause) 

 HDTRA1-10-C-004 

 Page
 7
 of 35 
  

 Section F - Deliveries or Performance 

DELIVERY INFORMATION 
  

									
	 CLIN
	  	 DELIVERY DATE
	  	QUANTITY	  	 SHIP TO ADDRESS
	  	UIC
					
	 0001
	  	 POP 21-APR-2010 TO

20-OCT-2011
	  	N/A	  	DEFENSE THREAT REDUCTION AGENCY/RD-CBM SEE SEPARATE LETTER 8725 JOHN J KINGMAN ROAD, MAIL STOP 6201, FORT BELVOIR VA 22060 FOB: Destination	  	HDTRA1
					
	 000101
	  	N/A	  	N/A	  	N/A	  	N/A
					
	 000102
	  	N/A	  	N/A	  	N/A	  	N/A
					
	 0002
	  	 POP 21-OCT-2011 TO
 20-APR-2013

	  	N/A	  	DEFENSE THREAT REDUCTION AGENCY/RD-CBM SEE SEPARATE LETTER 8725 JOHN J KINGMAN ROAD, MAIL STOP 6201, FORT BELVOIR VA 22060 FOB: Destination	  	HDTRA1
					
	 0003
	  	 POP 21-APR-2013 TO
 20-JAN-2014

	  	N/A	  	(SAME AS PREVIOUS LOCATION) FOB: Destination	  	HDTRA1
					
	 0004
	  	 POP 21-JAN-2014 TO
 20-SEP-2014

	  	N/A	  	(SAME AS PREVIOUS LOCATION) FOB: Destination	  	HDTRA1
					
	 0005
	  	 POP 21-JUN-2010 TO
 20-JUN-2012

	  	N/A	  	(SAME AS PREVIOUS LOCATION) FOB: Destination	  	HDTRA1
					
	 0006
	  	 POP 21-APR-2010 TO
 20-SEP-2014

	  	N/A	  	(SAME AS PREVIOUS LOCATION) FOB: Destination	  	HDTRA1

 CLAUSES INCORPORATED BY REFERENCE 

 

					
	52.242-15	 	Stop-Work Order	  	AUG 1989
	52.242-15 Alt I	 	Stop-Work Order (Aug 1989) - Alternate I	  	APR 1984
	52.247-34	 	F.O.B. Destination	  	NOV 1991

 HDTRA1-10-C-004 

 Page
 8
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 Section G - Contract Administration Data 

ACCOUNTING AND APPROPRIATION DATA 
 AA:
9790400.2620 1000 B62D 255999 BD30545000 S49012 
 AMOUNT: $1,136,766.00 

CIN CBM090014890000101: $1,136,766.00 
 AB:
9700400.2620 1000 B62D 255999 BD31540000 S49012 
 AMOUNT: $3,028,710.00 

CIN CBM090014890000102: $3,028,710.00 
 CLAUSES
INCORPORATED BY REFERENCE 
  

			
	252.232-7003	  	Electronic Submission of Payment Requests and Receiving Reports            MAR 2008

CLAUSES INCORPORATED BY FULL TEXT 
  

			
	252.201-9001	  	CONTRACTING OFFICE POINT OF CONTACT (POC)            (Dec 2007)

The POC in the Procuring Contracting Office for this contract action is See separate letter. 

CLAUSES INCORPORATED BY FULL TEXT 
  

			
	252.201-9002	  	CONTRACTING OFFICER’S REPRESENTATIVE (MAY 2007)

  

	 	a.	The Contracting Officer’s Representative (COR) for this contract is: 

  

	 	X	See Separate Letter 

 Defense
Threat Reduction Agency/             
 8725 John J. Kingman
Rd, MS 6201 
 Fort Belvoir VA 22060-6201 

Telephone number
(703)         -             

e-mail address
                        @dtra.mil. 

WAWF Acceptor DoDAAC: HDTRA1 

 HDTRA1-10-C-004 

 Page
 9
 of 35 
  

 Defense Threat Reduction
Agency/             
 1680 Texas St SE 

Kirtland AFB NM 87117-5669 

Telephone number
(505)         -             

e-mail address
                    @abq.dtra.mil. 

WAWF Acceptor DoDAAC: HDTRA2 

b. The COR will act as the Contracting Officer’s Representative for technical matters providing technical direction and discussion
as necessary with respect to the specification/statement of work and monitoring the progress and quality of the Contractor’s performance. The COR is NOT an Administrative Contracting Officer (ACO) and does not have the authority to take any
action, either directly or indirectly that would change the pricing, quality, quantity, place of performance, delivery schedule, or any other terms and conditions of the contract, or to direct the accomplishment of effort, which goes beyond the
scope of the specifications/statement of work in the contract. 
 c. When, in the opinion of the contractor, the COR requests
effort outside the existing scope of the contract, the contractor shall promptly notify the Contracting Officer in writing. No action shall be taken by the contractor under such direction until the Contracting Officer has issued a modification to
the contract or has otherwise resolved the issue. 
 CLAUSES INCORPORATED BY FULL TEXT 

 

			
	252.204-9002	  	PAYMENT INSTRUCTIONS FOR MULTIPLE ACCOUNTING CLASSIFICATION CITATIONS (AUG 2007)

In accordance with DFARS 204.7108 Payment Instructions, payment shall be made by the numbered payment instruction identified below: 

            (1) Line item specific: single funding. If there is only one source
of funding for the contract line item (i.e., one ACRN), the payment office will make payment using the ACRN funding of the line item being billed. 

    X     (2) Line item specific: sequential ACRN order. If there is more than one ACRN
within a contract line item, the payment office will make payment in sequential ACRN order within the line item, exhausting all funds in the previous ACRN before paying from the next ACRN using the following sequential order: Alpha/Alpha;
Alpha/Numeric; Numeric/Alpha; and Numeric/Numeric. 
             (3) Line
item specific: contracting officer specified ACRN order. If there is more than one ACRN within a contract line item, the payment office will make payment within the line item in the sequence ACRN order specified by the contracting officer,
exhausting all funds in the previous ACRN before paying from the next ACRN. 

            (4) Line item specific: by fiscal year. If there is more than one
ACRN within a contract line item, the payment office will make payment using the oldest fiscal year appropriations first, exhausting all funds in the previous fiscal year before disbursing from the next fiscal year. In the event there is more than
one ACRN associated with the same fiscal year, the payment amount shall be disbursed from each ACRN within a fiscal year in the same proportion as the amount of funding obligated for each ACRN within the fiscal year. 

 HDTRA1-10-C-004 

 Page
 10
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             (5) Line item
specific: by cancellation date. If there is more than one ACRN within a contract line item, the payment office will make payment using the ACRN with the earliest cancellation date first, exhausting all funds in that ACRN before disbursing funds
from the next. In the event there is more than one ACRN associated with the same cancellation date, the payment amount shall be disbursed from each ACRN with the same cancellation date in the same proportion as the amount of funding obligated for
each ACRN with the same cancellation date. 
             (6) Line item
specific: proration. If there is more than one ACRN within a contract line item, the payment office will make payment from each ACRN in the same proportion as the amount of funding currently unliquidated for each ACRN. 

            (7) Contract-wide: sequential ACRN order. The payment office will
make payment in sequential ACRN order within the contract or order, exhausting all funds in the previous ACRN before paying from the next ACRN using the following sequential order: alpha/alpha; alpha/numeric; numeric/alpha; and numeric/numeric.

             (8) Contract-wide: contracting officer specified ACRN
order The payment office will make payment in sequential ACRN order within the contract or order, exhausting all funds in the previous ACRN before paying from the next ACRN in the sequence order specified by the contracting officer. 

            (9) Contract-wide: by fiscal year. The payment office will make
payment using the oldest fiscal year appropriations first, exhausting all funds in the previous fiscal year before disbursing from the next fiscal year. In the event there is more than one ACRN associated with the same fiscal year, the payment
amount shall be disbursed from each ACRN within a fiscal year in the same proportion as the amount of funding obligated for each ACRN within the fiscal year. 

            (10) Contract-wide: by cancellation date. The payment office will
make payment using the ACRN with the earliest cancellation date first, exhausting all funds in that ACRN before disbursing funds from the next. In the event there is more than one ACRN associated with the same cancellation date, the payment amount
shall be disbursed from each ACRN with the same cancellation date in the same proportion as the amount of funding obligated for each ACRN with the same cancellation date. 

            (11) Contract-wide: proration. The payment office will make payment
from each ACRN within the contract or order in the same proportion as the amount of funding currently unliquidated for each ACRN. 

            (12) Other. If none of the standard payment instructions identified
in paragraphs (d)(1) through (11) of this section are appropriate, the contracting officer may insert other payment instructions, provided the other payment instructions— 

(i) Provide a significantly better reflection of how funds will be expended in support of contract performance; and 

(ii) Are agreed to by the payment office and the contract administration office. 

CLAUSES INCORPORATED BY FULL TEXT 

252.216-9005 PROFIT OR FEE ON TRAVEL COSTS (JUL 2008) 

Travel shall not be a profit or fee bearing cost element. 

(End of clause) 

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 CLAUSES INCORPORATED BY FULL TEXT 

 

			
	252.232-9000	  	CONTRACT FUNDING PROFILE (OCT 1998)

 Subject to FAR
Clause 52.232-22, Limitation of Funds, the amount of $4,165,476 is obligated for work to be performed during the period beginning with contract award and continuing through March 30, 2011. Additional incremental funding planned, but not
obligated, is: 
 FY11  $2,649,122 

(End of clause) 
 CLAUSES INCORPORATED BY FULL
TEXT 
  

			
	252.232-9001	  	PRICES/COST

 a. Subject to the provisions of the Clauses of
this Contract entitled LIMITATION OF FUNDS, ALLOWABLE COST AND PAYMENT, and FIXED FEE, the total allowable cost under this Contract shall not exceed $             A
                     , which is the total estimated cost of the Contractor’s performance hereunder, exclusive of fixed fee. In
addition, the Government shall pay the Contractor a fixed fee of $            
B                 for the performance of this Contract. It is understood and agreed that the Government’s obligation is limited to INCREMENTAL FUNDING
in the amount of $             C                 . Within this amount
($             C                 ), the fixed fee shall bear the same relationship to the total
fixed fee, as the costs incurred bear to the total estimated cost. 
 b. Interim payment vouchers may be submitted for provisional payment
pursuant to the Clauses of this Contract entitled ALLOWABLE COST AND PAYMENT and FIXED FEE. 
 Fill in the dollar amounts as applicable:

 [...***...] 

[...***...] 
 C:  $4,165,476

 CLAUSES INCORPORATED BY FULL TEXT 
  

			
	252.232-9007	  	PAYMENT INFORMATION IN CENTRAL CONTRACTOR REGISTRATION (CCR) DATABASE

This contract contains FAR clause 52.204-7, Central Contractor Registration. All contractors must be registered in the CCR database prior
to award, during performance, and through final payment of any contract, except for awards to foreign vendors for work to be performed outside the United States. 

 

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 The Contractor is responsible for the accuracy and completeness of the data within the
CCR, and for any liability resulting from the Government’s reliance on inaccurate or incomplete data. In addition to the contractor’s requirement to confirm on an annual basis that its information in the CCR database is accurate and
complete, the contractor’s information in the CCR database must be updated whenever changes occur to the contractor’s remit-to data (e.g., account number, vendor name and address, etc.) and the paying office notified of any changes. The
contractor’s failure to maintain accurate information in the CCR database could result in payment delays for which the Government shall not be liable. 

CLAUSES INCORPORATED BY FULL TEXT 

252.232-9012 WIDE AREA WORK FLOW (WAWF) – RECEIPT AND ACCEPTANCE (RA) INSTRUCTIONS (September 2008) 

(a) As prescribed in DFARS clause 252.232-7003 Electronic Submission of Payment Requests (Jan 2004), Contractors must submit payment requests in
electronic form. Paper copies will no longer be accepted or processed for payment unless the conditions of DFARS clause 252.232-7003(c) apply. To facilitate this electronic submission, the Defense Threat Reduction Agency (DTRA) has implemented the
DoD sanctioned Wide Area Workflow-Receipt and Acceptance (WAWF-RA) for contractors to submit electronic payment requests and receiving reports. The contractor shall submit electronic payment requests and receiving reports via WAWF-RA. Vendors
shall send an email notification to the Contracting Officer Representative (COR), Program/Project Manager or other government acceptance official identified in the contract by clicking on the Send More Email Notification link upon submission of an
invoice/cost voucher in WAWF-RA. To access WAWF, go to https://wawf.eb.mil//.  
 ** For questions, contact the DTRA WAWF Team at
703-767-6840 or wawfhelp@dtra.mil ** 
 (b) Definitions: 

Acceptor: Contracting Officer’s Representative, Program/Project Manager, or other government acceptance official as identified in the
contract/order. 
 Pay Official: Defense Finance and Accounting Service (DFAS) payment office identified in the contract/order.

 SHIP To/Service Acceptor DoDAAC: Acceptor DoDAAC or DCMA DoDAAC (as specified in the contract/order). 

DCAA Auditor DoDAAC: Needed when invoicing on cost-reimbursable contracts. (Go to www.dcaa.mil and click on the appropriate link under the Audit
Office Locator to search for your DCAA DoDAAC.) 
  

					
	>>>>>	  	 For contracts that are administered by the Office of Naval Research (ONR):

Enter the ONR DoDAAC in the DCAA Auditor DoDAAC field in WAWF.
	  	<<<<<

 (c) WAWF Contractor Input
Information: 
 The contractor shall use the following information in creating electronic payment requests in WAWF: 

Invoice Type in WAWF: 
 If
billing for Cost Type/Reimbursable contracts (including T&M and LH), select “Cost Voucher” 
 If billing for
Firm-Fixed Price (FFP) Materials Only, select “Combo” 
 If billing for FFP Materials and Service, select
“Combo” 
 If billing for FFP Services Only, select “2-n-1 (Services Only)” 

** If the contract contains both FFP and Cost Type (including T&M and LH) line items, they must be invoiced separately on appropriate
types mentioned above. Upon the written approval of the Project Manager or Contracting Officer’s Representative, the contractor may invoice both line items in one type of invoice. 

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 For WAWF Routing Information, See Table Below: 

 

									
	Description	 	SF 26	 	SF 33	 	SF 1449	 	DD 1155
	 	Located in Block/Section
	Contract Number	 	2	 	2	 	2	 	1
	Delivery Order	 	See Individual Order	 	4	 	2
	CAGE Code	 	7	 	15a	 	17a	 	9
	Pay DoDAAC	 	12	 	25	 	18a	 	15
	Inspection	 	 Section E (except SF 1449, See Entitled):

INSPECTION AND ACCEPTANCE

	Acceptance	 	 Section E (except SF 1449, See Entitled):

INSPECTION AND ACCEPTANCE

	Issue Date	 	3	 	5	 	3	 	3
	Issue By DoDAAC	 	5	 	7	 	9	 	6
	Admin DoDAAC	 	6	 	24	 	16	 	7
	Ship To / Service Acceptor DoDAAC	 	6	 	24	 	16	 	7
	Ship to Extension	 	Do Not Fill In
	Services or Supplies	 	Based on majority of requirement as determined by monetary value
	Final Invoice?	 	Do not change “N” (no) to “Y” (yes) unless this is the last invoice and the contract is ready for closeout.

(d) Final Invoices/Vouchers -Final Payment shall be made in accordance with the Federal Acquisition Regulation (FAR) 52.216-7, entitled
“Allowable Cost and Payment.” 
 Invoices - Invoice 2-n-1 (Services Only) and Invoice and Receiving Report (Combo)
Select the “Y” selection from the “Final Invoice?” drop-down box when submitting the final invoice for payment for a contract. Upon successful submission of the final invoice, click on the
Send More Email Notifications link to send an additional email notification to the Contracting Officer Representative (COR), Program/Project Manager or other government acceptance official identified in the contract. 

Cost Vouchers - Once the final DCAA audit is complete for cost reimbursable contracts and authorization is received to submit the final
cost voucher, select the “Y” selection from the “Final Voucher” drop-down box when submitting the final cost voucher. Upon successful submission of the final cost voucher, click on the
Send More Email Notifications link to send an additional email notification to the following email address: finalcostvouchers@dtra.mil 

(e) WAWF Training may be accessed online at http://www.wawftraining.com//. To practice creating documents in WAWF, visit practice site at
https://wawftraining.eb.mil//. General DFAS information may be accessed using the DFAS website at http://www.dod.mil/dfas//. Payment status information may be accessed using the myInvoice

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system at https://myinvoice.csd.disa.mil// or by calling the DFAS Columbus helpdesk at 800-756-4571. (Select Option 1) Your contract number and shipment/invoice number will be required to
check status of your payment. Note: For specific invoice related inquiries email: wawfvendorpay@dtra.mil. Vendors shall forward any additional DTRA related WAWF questions to wawfhelp@dtra.mil. 

CLAUSES INCORPORATED BY FULL TEXT 

252.242-9003 - ASSIGNMENT OF CONTRACT ADMINISTRATION SERVICES (CAS) FUNCTIONS (AUG 2009) 

 

	a.	The contract administration functions stated in FAR 42.302(a) are assigned to: See Page 1, Section A, Block 6 of this contract. 

 

	b.	Notwithstanding that assignment, in accordance with FAR 42.202(b)(2), the following functions are determined to be best performed by the PCO and are retained by the
DTRA Contracting Office: 

 (1) FAR 42.302(a)(3) Conduct Postaward orientation conferences.

 (2) FAR 42.302(a)(20) Perform Postaward Security Administration. 

(3) FAR 42.302(a)(40) Perform engineering surveillance to assess compliance with contractual terms for schedule, cost, and
technical performance in the areas of design, development, and production. 
 (4) FAR 42.302(a)(51) In accordance
with FAR 52.244-2, consent to the placement of subcontracts which have experimental, developmental, or research work as one of its purposes. 

(5) Approval or disapproval of the data items listed on Exhibit A, DD Form 1423, Contract Data Requirements List.

 (END OF CLAUSE) 

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 Section H - Special Contract Requirements 

RIGHTS IN MATERIAL 

RIGHTS IN MATERIAL - - [...***...] 
  

	(a)	Definitions. As used in this clause: 

  

	 	(1)	“Collection” means [...***...] this contract. 

  

	 	(2)	“Collected exclusively with government funds” means [...***...] expense. 

 

	 	(3)	“Material” refers to [...***...] above. 

  

	 	(4)	“[...***...] rights” means rights to [...***...] in whole or in part, in any manner, and for any purpose whatsoever, and to have or authorize
others to do so. 

  

	(b)	Rights in [...***...] the following [...***...] rights: 

 

	 	(1)	[...***...] rights. The Government shall [...***...] rights in [...***...] that are – 

 

	 	(i)	[...***...] which have been or will be [...***...]; 

  

	 	(ii)	[...***...] for this contract, when the [...***...]. 

  

	(c)	Specifics. The Contractor and the Government agree to the following: 

 

	 	(1)	The [...***...] shall reside with the subcontractor – [...***...]. 

 

	 	(2)	The [...***...] rights conveyed to the U.S. Government, under this contract, does not [...***...]. 

 

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	 	(3)	Copies of the collection, as defined under section (a) of this clause, will be made available to U.S. Government agencies, to include Department of Defense, upon
request. 

  

	 	(4)	The [...***...] prior to execution of this contract [...***...]. 

 

	 	(5)	Upon completion of the contract, the collection – as defined under section (a) of this clause – [...***...] the U.S. Government.

 End clause 

H.1 PATENT RIGHTS 
 RETENTION BY THE
CONTRACTOR 
 In accordance with FAR 52.227-11(f), reporting on utilization of subject inventions: 

The Contractor agrees to submit, periodic reports annually on the utilization of a subject invention or efforts at obtaining such utilization that are
being made by the Contractor or its licensees or assignees. 
 INDIRECT COST RATES CEILING In accordance with FAR 42.707(c) (1) (2),
reimbursement for indirect costs under this contract shall be at billing rates but not in excess of the following negotiated ceiling rates: 

2010: 
 Fringe: [...***...] 

G&A: [...***...] 
 M&S Handling:
[...***...] 
 Overhead: [...***...] 

2011: 
 Fringe: [...***...] 

G&A: [...***...] 
 M&S Handling:
[...***...] 
 Overhead: [...***...] 

2012: 
 Fringe: [...***...] 

 

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 G&A: [...***...] 

M&S Handling: [...***...] 
 Overhead:
[...***...] 
 2013: 
 Fringe:
[...***...] 
 G&A: [...***...] 

M&S Handling: [...***...] 
 Overhead:
[...***...] 
 2014: 
 Fringe:
[...***...] 
 G&A: [...***...] 

M&S Handling: [...***...] 
 Overhead:
[...***...] 
 The Government will not be obligated to pay any additional amount should the final indirect cost rates exceed the
negotiated ceiling rates. In the event the final indirect cost rates are less than the negotiated ceiling rates, the negotiated rates will be reduced to conform to the lower rates. 

POST AWARD AUDIT 
 IAW FAR Part 42.102 A
Post Award audit will be requested, by the Contracting Officer, 6 months after award of contract. The audit will include indirect rates, review of the contractor’s accounting system, and review of the contractor’s purchasing system. Any
and all capped rates shall become final indirect rates upon rate approval by DCAA. 
 Upon receipt of negative findings from DCAA, the
government may elect to terminate the contract pursuant to FAR 52.249-6 or they may elect to re-open negotiations for downward adjustments of indirect rates, if required. 
  

 ***Confidential Treatment Requested 

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 Section I - Contract Clauses 

CLAUSES INCORPORATED BY REFERENCE 
  

					
	52.202-1	  	Definitions	  	JUL 2004
	52.203-3	  	Gratuities	  	APR 1984
	52.203-5	  	Covenant Against Contingent Fees	  	APR 1984
	52.203-6	  	Restrictions On Subcontractor Sales To The Government	  	SEP 2006
	52.203-7	  	Anti-Kickback Procedures	  	JUL 1995
	52.203-8	  	Cancellation, Rescission, and Recovery of Funds for Illegal or Improper Activity	  	JAN 1997
	52.203-10	  	Price Or Fee Adjustment For Illegal Or Improper Activity	  	JAN 1997
	52.203-12	  	Limitation On Payments To Influence Certain Federal Transactions	  	SEP 2007
	52.203-13	  	Contractor Code of Business Ethics and Conduct	  	DEC 2008
	52.203-14	  	Display of Hotline Poster(s)	  	DEC 2007
	52.204-4	  	Printed or Copied Double-Sided on Recycled Paper	  	AUG 2000
	52.204-7	  	Central Contractor Registration	  	APR 2008
	52.209-6	  	Protecting the Government’s Interest When Subcontracting With Contractors Debarred, Suspended, or Proposed for Debarment	  	SEP 2006
	52.215-2	  	Audit and Records—Negotiation	  	MAR 2009
	52.215-8	  	Order of Precedence—Uniform Contract Format	  	OCT 1997
	52.215-10	  	Price Reduction for Defective Cost or Pricing Data	  	OCT 1997
	52.215-12	  	Subcontractor Cost or Pricing Data	  	OCT 1997
	52.215-15	  	Pension Adjustments and Asset Reversions	  	OCT 2004
	52.215-17	  	Waiver of Facilities Capital Cost of Money	  	OCT 1997
	52.215-18	  	Reversion or Adjustment of Plans for Postretirement Benefits (PRB) Other than Pensions	  	JUL 2005
	52.215-19	  	Notification of Ownership Changes	  	OCT 1997
	52.215-21	  	Requirements for Cost or Pricing Data or Information Other Than Cost or Pricing Data—Modifications	  	OCT 1997
	52.215-23	  	Limitations on Pass-Through Charges	  	OCT 2009
	52.216-7	  	Allowable Cost And Payment	  	DEC 2002
	52.216-8	  	Fixed Fee	  	MAR 1997
	52.219-8	  	Utilization of Small Business Concerns	  	MAY 2004
	52.222-3	  	Convict Labor	  	JUN 2003
	52.222-21	  	Prohibition Of Segregated Facilities	  	FEB 1999
	52.222-26	  	Equal Opportunity	  	MAR 2007
	52.222-35	  	Equal Opportunity For Special Disabled Veterans, Veterans of the Vietnam Era, and Other Eligible Veterans	  	SEP 2006
	52.222-36	  	Affirmative Action For Workers With Disabilities	  	JUN 1998
	52.222-37	  	Employment Reports On Special Disabled Veterans, Veterans Of The Vietnam Era, and Other Eligible Veterans	  	SEP 2006
	52.222-50	  	Combating Trafficking in Persons	  	FEB 2009
	52.222-54	  	Employment Eligibility Verification	  	JAN 2009
	52.223-6	  	Drug-Free Workplace	  	MAY 2001
	52.223-14	  	Toxic Chemical Release Reporting	  	AUG 2003
	52.225-13	  	Restrictions on Certain Foreign Purchases	  	JUN 2008
	52.227-1	  	Authorization and Consent	  	DEC 2007
	52.227-1 Alt I	  	Authorization And Consent (Dec 2007) - Alternate I	  	APR 1984
	52.227-2	  	Notice And Assistance Regarding Patent And Copyright Infringement	  	DEC 2007
	52.227-11	  	Patent Rights—Ownership By The Contractor	  	DEC 2007

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	52.227-11 Alt II	  	Patent Rights—Ownership by the Contractor (Dec 2007) – Alternate II	  	DEC 2007
	52.228-7	  	Insurance—Liability To Third Persons	  	MAR 1996
	52.229-10	  	State of New Mexico Gross Receipts and Compensating Tax	  	APR 2003
	52.232-9	  	Limitation On Withholding Of Payments	  	APR 1984
	52.232-17	  	Interest	  	OCT 2008
	52.232-23	  	Assignment Of Claims	  	JAN 1986
	52.232-23 Alt I	  	Assignment of Claims (Jan 1986) -Alternate I	  	APR 1984
	52.232-25	  	Prompt Payment	  	OCT 2008
	52.232-25 Alt I	  	Prompt Payment (Oct 2008) Alternate I	  	FEB 2002
	52.232-33	  	Payment by Electronic Funds Transfer—Central Contractor	  	OCT 2003
	52.233-1	  	Disputes	  	JUL 2002
	52.233-1 Alt I	  	Disputes (Jul 2002) - Alternate I	  	DEC 1991
	52.233-3	  	Protest After Award	  	AUG 1996
	52.233-3 Alt I	  	Protest After Award (Aug 1996) - Alternate I	  	JUN 1985
	52.233-4	  	Applicable Law for Breach of Contract Claim	  	OCT 2004
	52.242-1	  	Notice of Intent to Disallow Costs	  	APR 1984
	52.242-3	  	Penalties for Unallowable Costs	  	MAY 2001
	52.242-4	  	Certification of Final Indirect Costs	  	JAN 1997
	52.242-13	  	Bankruptcy	  	JUL 1995
	52.243-2	  	Changes—Cost-Reimbursement	  	AUG 1987
	52.243-2 Alt V	  	Changes—Cost-Reimbursement (Aug 1987) - Alternate V	  	APR 1984
	52.244-2	  	Subcontracts	  	JUN 2007
	52.244-5	  	Competition In Subcontracting	  	DEC 1996
	52.244-6	  	Subcontracts for Commercial Items	  	AUG 2009
	52.245-1	  	Government Property	  	JUN 2007
	52.245-1 (Dev)	  	Government Property (June 2007)	  	JUN 2007
	52.245-9	  	Use And Charges	  	JUN 2007
	52.246-25	  	Limitation Of Liability—Services	  	FEB 1997
	52.249-6	  	Termination (Cost Reimbursement)	  	MAY 2004
	52.249-14	  	Excusable Delays	  	APR 1984
	52.251-1	  	Government Supply Sources	  	APR 1984
	52.253-1	  	Computer Generated Forms	  	JAN 1991
	252.201-7000	  	Contracting Officer’s Representative	  	DEC 1991
	252.203-7000	  	Requirements Relating to Compensation of Former DoD Officials	  	JAN 2009
	252.203-7001	  	Prohibition On Persons Convicted of Fraud or Other Defense-Contract-Related Felonies	  	DEC 2008
	252.203-7002	  	Requirement to Inform Employees of Whistleblower Rights	  	JAN 2009
	252.204-7000	  	Disclosure Of Information	  	DEC 1991
	252.204-7003	  	Control Of Government Personnel Work Product	  	APR 1992
	252.204-7004 Alt A	  	Central Contractor Registration (52.204-7) Alternate A	  	SEP 2007
	252.204-7009	  	Requirements Regarding Potential Access to Export-Controlled Items	  	JUL 2008
	252.205-7000	  	Provision Of Information To Cooperative Agreement Holders	  	DEC 1991
	252.209-7004	  	Subcontracting With Firms That Are Owned or Controlled By The Government of a Terrorist Country	  	DEC 2006
	252.211-7003	  	Item Identification and Valuation	  	AUG 2008
	252.211-7007	  	Reporting of Government-Furnished Equipment in the DoD Item Unique Identification (IUID) Registry	  	NOV 2008
	252.215-7000	  	Pricing Adjustments	  	DEC 1991
	252.215-7002	  	Cost Estimating System Requirements	  	DEC 2006

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	252.222-7999 (Dev)	  	Additional Requirements and Responsibilities Restricting the Use of Mandatory Arbitration Agreements (Deviation)	  	FEB 2010
	252.225-7004	  	Report of Intended Performance Outside the United States and Canada—Submission after Award	  	MAY 2007
	252.225-7006	  	Quarterly Reporting of Actual Contract Performance Outside the United States	  	MAY 2007
	252.225-7012	  	Preference For Certain Domestic Commodities	  	DEC 2008
	252.226-7001	  	Utilization of Indian Organizations and Indian-Owned Economic Enterprises, and Native Hawaiian Small Business Concerns	  	SEP 2004
	252.227-7013	  	Rights in Technical Data—Noncommercial Items	  	NOV 1995
	252.227-7016	  	Rights in Bid or Proposal Information	  	JUN 1995
	252.227-7025	  	Limitations on the Use or Disclosure of Government-Furnished Information Marked with Restrictive Legends	  	JUN 1995
	252.227-7027	  	Deferred Ordering Of Technical Data Or Computer Software	  	APR 1988
	252.227-7030	  	Technical Data—Withholding Of Payment	  	MAR 2000
	252.227-7037	  	Validation of Restrictive Markings on Technical Data	  	SEP 1999
	252.227-7039	  	Patents—Reporting Of Subject Inventions	  	APR 1990
	252.231-7000	  	Supplemental Cost Principles	  	DEC 1991
	252.232-7003	  	Electronic Submission of Payment Requests and Receiving Reports	  	MAR 2008
	252.232-7010	  	Levies on Contract Payments	  	DEC 2006
	252.235-7002	  	Animal Welfare	  	DEC 1991
	252.235-7010	  	Acknowledgment of Support and Disclaimer	  	MAY 1995
	252.235-7011	  	Final Scientific or Technical Report	  	NOV 2004
	252.243-7002	  	Requests for Equitable Adjustment	  	MAR 1998
	252.244-7000	  	Subcontracts for Commercial Items and Commercial Components (DoD Contracts)	  	AUG 2009
	252.247-7023	  	Transportation of Supplies by Sea	  	MAY 2002
	252.247-7024	  	Notification Of Transportation Of Supplies By Sea	  	MAR 2000
	252.251-7000	  	Ordering From Government Supply Sources	  	NOV 2004

 CLAUSES INCORPORATED BY FULL TEXT 

 

	52.216-7	ALLOWABLE COST AND PAYMENT (DEC 2002) 

 (a)
Invoicing. 
 (1) The Government will make payments to the Contractor when requested as work progresses, but (except for small business
concerns) not more often than once every 2 weeks, in amounts determined to be allowable by the Contracting Officer in accordance with Federal Acquisition Regulation (FAR) subpart 31.2 in effect on the date of this contract and the terms of this
contract. The Contractor may submit to an authorized representative of the Contracting Officer, in such form and reasonable detail as the representative may require, an invoice or voucher supported by a statement of the claimed allowable cost for
performing this contract. 
 (2) Contract financing payments are not subject to the interest penalty provisions of the Prompt Payment Act.
Interim payments made prior to the final payment under the contract are contract financing payments, except interim payments if this contract contains Alternate I to the clause at 52.232-25. 

(3) The designated payment office will make interim payments for contract financing on the 30th day after the designated billing office receives a proper
payment request. 

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 In the event that the Government requires an audit or other review of a specific payment request to
ensure compliance with the terms and conditions of the contract, the designated payment office is not compelled to make payment by the specified due date. 

(b) Reimbursing costs. (1) For the purpose of reimbursing allowable costs (except as provided in subparagraph (b)(2) of the clause, with respect to
pension, deferred profit sharing, and employee stock ownership plan contributions), the term “costs” includes only— 
 (i) Those
recorded costs that, at the time of the request for reimbursement, the Contractor has paid by cash, check, or other form of actual payment for items or services purchased directly for the contract; 

(ii) When the Contractor is not delinquent in paying costs of contract performance in the ordinary course of business, costs incurred, but not
necessarily paid, for— 
 (A) Supplies and services purchased directly for the contract and associated financing payments to
subcontractors, provided payments determined due will be made— 
 (1) In accordance with the terms and conditions of a subcontract or
invoice; and 
 (2) Ordinarily within 30 days of the submission of the Contractor’s payment request to the Government; 

(B) Materials issued from the Contractor’s inventory and placed in the production process for use on the contract; 

(C) Direct labor; 
 (D) Direct travel;

 (E) Other direct in-house costs; and 

(F) Properly allocable and allowable indirect costs, as shown in the records maintained by the Contractor for purposes of obtaining reimbursement under
Government contracts; and 
 (iii) The amount of financing payments that have been paid by cash, check, or other forms of payment to
subcontractors. 
 (2) Accrued costs of Contractor contributions under employee pension plans shall be excluded until actually paid unless—

 (i) The Contractor’s practice is to make contributions to the retirement fund quarterly or more frequently; and 

(ii) The contribution does not remain unpaid 30 days after the end of the applicable quarter or shorter payment period (any contribution remaining unpaid
shall be excluded from the Contractor’s indirect costs for payment purposes). 
 (3) Notwithstanding the audit and adjustment of invoices
or vouchers under paragraph (g) of this clause, allowable indirect costs under this contract shall be obtained by applying indirect cost rates established in accordance with paragraph (d) of this clause. 

(4) Any statements in specifications or other documents incorporated in this contract by reference designating performance of services or furnishing of
materials at the Contractor’s expense or at no cost to the Government shall be disregarded for purposes of cost-reimbursement under this clause. 

(c) Small business concerns. A small business concern may receive more frequent payments than every 2 weeks. 

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 (d) Final indirect cost rates. (1) Final annual indirect cost rates and the appropriate bases shall
be established in accordance with Subpart 42.7 of the Federal Acquisition Regulation (FAR) in effect for the period covered by the indirect cost rate proposal. 

(2)(i) The Contractor shall submit an adequate final indirect cost rate proposal to the Contracting Officer (or cognizant Federal agency official) and
auditor within the 6-month period following the expiration of each of its fiscal years. Reasonable extensions, for exceptional circumstances only, may be requested in writing by the Contractor and granted in writing by the Contracting Officer. The
Contractor shall support its proposal with adequate supporting data. 
 (ii) The proposed rates shall be based on the Contractor’s actual
cost experience for that period. The appropriate Government representative and the Contractor shall establish the final indirect cost rates as promptly as practical after receipt of the Contractor’s proposal. 

(3) The Contractor and the appropriate Government representative shall execute a written understanding setting forth the final indirect cost rates. The
understanding shall specify (i) the agreed-upon final annual indirect cost rates, 
 (ii) the bases to which the rates apply,
(iii) the periods for which the rates apply, (iv) any specific indirect cost items treated as direct costs in the settlement, and (v) the affected contract and/or subcontract, identifying any with advance agreements or special terms
and the applicable rates. The understanding shall not change any monetary ceiling, contract obligation, or specific cost allowance or disallowance provided for in this contract. The understanding is incorporated into this contract upon execution.

 (4) Failure by the parties to agree on a final annual indirect cost rate shall be a dispute within the meaning of the Disputes clause.

 (5) Within 120 days (or longer period if approved in writing by the Contracting Officer) after settlement of the final annual indirect cost
rates for all years of a physically complete contract, the Contractor shall submit a completion invoice or voucher to reflect the settled amounts and rates. 

(6)(i) If the Contractor fails to submit a completion invoice or voucher within the time specified in paragraph (d)(5) of this clause, the Contracting
Officer may— 
 (A) Determine the amounts due to the Contractor under the contract; and 

(B) Record this determination in a unilateral modification to the contract. 

(ii) This determination constitutes the final decision of the Contracting Officer in accordance with the Disputes clause. 

(e) Billing rates. Until final annual indirect cost rates are established for any period, the Government shall reimburse the Contractor at billing rates
established by the Contracting Officer or by an authorized representative (the cognizant auditor), subject to adjustment when the final rates are established. These billing rates— 

(1) Shall be the anticipated final rates; and 

(2) May be prospectively or retroactively revised by mutual agreement, at either party’s request, to prevent substantial overpayment or
underpayment. 
 (f) Quick-closeout procedures. Quick-closeout procedures are applicable when the conditions in FAR 42.708(a) are satisfied.

 (g) Audit. At any time or times before final payment, the Contracting Officer may have the Contractor’s invoices or vouchers and
statements of cost audited. Any payment may be (1) Reduced by amounts found by the Contracting Officer not to constitute allowable costs or (2) Adjusted for prior overpayments or underpayments. 

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 (h) Final payment. (1) Upon approval of a completion invoice or voucher submitted by the Contractor
in accordance with paragraph (d)(4) of this clause, and upon the Contractor’s compliance with all terms of this contract, the Government shall promptly pay any balance of allowable costs and that part of the fee (if any) not previously paid.

 (2) The Contractor shall pay to the Government any refunds, rebates, credits, or other amounts (including interest, if any) accruing to or
received by the Contractor or any assignee under this contract, to the extent that those amounts are properly allocable to costs for which the Contractor has been reimbursed by the Government. Reasonable expenses incurred by the Contractor for
securing refunds, rebates, credits, or other amounts shall be allowable costs if approved by the Contracting Officer. Before final payment under this contract, the Contractor and each assignee whose assignment is in effect at the time of final
payment shall execute and deliver— 
 (i) An assignment to the Government, in form and substance satisfactory to the Contracting Officer,
of refunds, rebates, credits, or other amounts (including interest, if any) properly allocable to costs for which the Contractor has been reimbursed by the Government under this contract; and 

(ii) A release discharging the Government, its officers, agents, and employees from all liabilities, obligations, and claims arising out of or under this
contract, except— 
 (A) Specified claims stated in exact amounts, or in estimated amounts when the exact amounts are not known;

 (B) Claims (including reasonable incidental expenses) based upon liabilities of the Contractor to third parties arising out of the
performance of this contract; provided, that the claims are not known to the Contractor on the date of the execution of the release, and that the Contractor gives notice of the claims in writing to the Contracting Officer within 6 years following
the release date or notice of final payment date, whichever is earlier; and 
 (C) Claims for reimbursement of costs, including reasonable
incidental expenses, incurred by the Contractor under the patent clauses of this contract, excluding, however, any expenses arising from the Contractor’s indemnification of the Government against patent liability. 

(End of clause) 
 CLAUSES INCORPORATED BY FULL
TEXT 
  

	52.217-8	OPTION TO EXTEND SERVICES (NOV 1999) 

 The
Government may require continued performance of any services within the limits and at the rates specified in the contract. These rates may be adjusted only as a result of revisions to prevailing labor rates provided by the Secretary of Labor. The
option provision may be exercised more than once, but the total extension of performance hereunder shall not exceed 6 months. The Contracting Officer may exercise the option by written notice to the Contractor up to end of period of performance.

 (End of clause) 
 CLAUSES
INCORPORATED BY FULL TEXT 
  

	52.217-9	OPTION TO EXTEND THE TERM OF THE CONTRACT (MAR 2000) 

(a) The Government may extend the term of this contract by written notice to the Contractor prior to end of period of performance; provided that the
Government gives the Contractor a preliminary written notice of its intent to extend at least 30 days before the contract expires. The preliminary notice does not commit the Government to an extension. 

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 (b) If the Government exercises this option, the extended contract shall be considered to include this
option clause. 
 (c) The total duration of this contract, including the exercise of any options under this clause, shall not exceed 60 months.

 (d) Option Task 4.1 shall be exercised no later than 30 days after demonstration of Proof of Principle (POP) and POP Milestone Report
submission. 
 CLAUSES INCORPORATED BY FULL TEXT 
  

	52.219-28	POST-AWARD SMALL BUSINESS PROGRAM REREPRESENTATION (APR 2009) 

(a) Definitions. As used in this clause— 

Long-term contract means a contract of more than five years in duration, including options. However, the term does not include contracts that exceed five
years in duration because the period of performance has been extended for a cumulative period not to exceed six months under the clause at 52.217-8, Option to Extend Services, or other appropriate authority. 

Small business concern means a concern, including its affiliates, that is independently owned and operated, not dominant in the field of operation in
which it is bidding on Government contracts, and qualified as a small business under the criteria in 13 CFR part 121 and the size standard in paragraph (c) of this clause. Such a concern is “not dominant in its field of operation”
when it does not exercise a controlling or major influence on a national basis in a kind of business activity in which a number of business concerns are primarily engaged. In determining whether dominance exists, consideration shall be given to all
appropriate factors, including volume of business, number of employees, financial resources, competitive status or position, ownership or control of materials, processes, patents, license agreements, facilities, sales territory, and nature of
business activity. 
 (b) If the Contractor represented that it was a small business concern prior to award of this contract, the Contractor
shall rerepresent its size status according to paragraph (e) of this clause or, if applicable, paragraph (g) of this clause, upon the occurrence of any of the following: 

(1) Within 30 days after execution of a novation agreement or within 30 days after modification of the contract to include this clause, if the novation
agreement was executed prior to inclusion of this clause in the contract. 
 (2) Within 30 days after a merger or acquisition that does not
require a novation or within 30 days after modification of the contract to include this clause, if the merger or acquisition occurred prior to inclusion of this clause in the contract. 

(3) For long-term contracts— 
 (i) Within
60 to 120 days prior to the end of the fifth year of the contract; and 
 (ii) Within 60 to 120 days prior to the date specified in the contract
for exercising any option thereafter. 
 (c) The Contractor shall rerepresent its size status in accordance with the size standard in effect at
the time of this rerepresentation that corresponds to the North American Industry Classification System (NAICS) code assigned to this contract. The small business size standard corresponding to this NAICS code can be found at
http://www.sba.gov/services/contractingopportunities/sizestandardstopics/. 

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 (d) The small business size standard for a Contractor providing a product which it does not manufacture
itself, for a contract other than a construction or service contract, is 500 employees. 
 (e) Except as provided in paragraph (g) of this
clause, the Contractor shall make the rerepresentation required by paragraph (b) of this clause by validating or updating all its representations in the Online Representations and Certifications Application and its data in the Central
Contractor Registration, as necessary, to ensure that they reflect the Contractor’s current status. The Contractor shall notify the contracting office in writing within the timeframes specified in paragraph (b) of this clause that the data
have been validated or updated, and provide the date of the validation or update. 
 (f) If the Contractor represented that it was other than a
small business concern prior to award of this contract, the Contractor may, but is not required to, take the actions required by paragraphs (e) or (g) of this clause. 

(g) If the Contractor does not have representations and certifications in ORCA, or does not have a representation in ORCA for the NAICS code applicable
to this contract, the Contractor is required to complete the following rerepresentation and submit it to the contracting office, along with the contract number and the date on which the rerepresentation was completed: 

The Contractor represents that it ( X ) is, ( ) is not a small business concern under NAICS Code 541711- assigned to contract number HDTRA1-10-C-0004.

 (Contractor to sign and date and insert authorized signer’s name and title). 

(End of clause) 
 CLAUSES INCORPORATED BY FULL
TEXT 
  

	52.222-2	PAYMENT FOR OVERTIME PREMIUMS (JUL 1990) 

 (a)
The use of overtime is authorized under this contract if the overtime premium cost does not exceed 0.00 or the overtime premium is paid for work — 

(1) Necessary to cope with emergencies such as those resulting from accidents, natural disasters, breakdowns of production equipment, or occasional
production bottlenecks of a sporadic nature; 
 (2) By indirect-labor employees such as those performing duties in connection with
administration, protection, transportation, maintenance, standby plant protection, operation of utilities, or accounting; 
 (3) To perform
tests, industrial processes, laboratory procedures, loading or unloading of transportation conveyances, and operations in flight or afloat that are continuous in nature and cannot reasonably be interrupted or completed otherwise; or 

(4) That will result in lower overall costs to the Government. 

(b) Any request for estimated overtime premiums that exceeds the amount specified above shall include all estimated overtime for contract completion and
shall— 
 (1) Identify the work unit; e.g., department or section in which the requested overtime will be used, together with present
workload, staffing, and other data of the affected unit sufficient to permit the Contracting Officer to evaluate the necessity for the overtime; 

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 (2) Demonstrate the effect that denial of the request will have on the contract delivery or performance
schedule; 
 (3) Identify the extent to which approval of overtime would affect the performance or payments in connection with other Government
contracts, together with identification of each affected contract; and 
 (4) Provide reasons why the required work cannot be performed by using
multishift operations or by employing additional personnel. 
  

	*	Insert either “zero” or the dollar amount agreed to during negotiations. The inserted figure does not apply to the exceptions in paragraph (a)(1) through
(a)(4) of the clause. 

 (End of clause) 
  

	52.232-22	LIMITATION OF FUNDS (APR 1984) 

 (a) The parties
estimate that performance of this contract will not cost the Government more than (1) the estimated cost specified in the Schedule or, (2) if this is a cost-sharing contract, the Government’s share of the estimated cost specified in
the Schedule. The Contractor agrees to use its best efforts to perform the work specified in the Schedule and all obligations under this contract within the estimated cost, which, if this is a cost-sharing contract, includes both the
Government’s and the Contractor’s share of the cost. 
 (b) The Schedule specifies the amount presently available for payment by the
Government and allotted to this contract, the items covered, the Government’s share of the cost if this is a cost-sharing contract, and the period of performance it is estimated the allotted amount will cover. The parties contemplate that the
Government will allot additional funds incrementally to the contract up to the full estimated cost to the Government specified in the Schedule, exclusive of any fee. The Contractor agrees to perform, or have performed, work on the contract up to the
point at which the total amount paid and payable by the Government under the contract approximates but does not exceed the total amount actually allotted by the Government to the contract. 

(c) The Contractor shall notify the Contracting Officer in writing whenever it has reason to believe that the costs it expects to incur under this
contract in the next 60 days, when added to all costs previously incurred, will exceed 75 percent of (1) the total amount so far allotted to the contract by the Government or, (2) if this is a cost-sharing contract, the amount then
allotted to the contract by the Government plus the Contractor’s corresponding share. The notice shall state the estimated amount of additional funds required to continue performance for the period specified in the Schedule. 

(d) Sixty days before the end of the period specified in the Schedule, the Contractor shall notify the Contracting Officer in writing of the estimated
amount of additional funds, if any, required to continue timely performance under the contract or for any further period specified in the Schedule or otherwise agreed upon, and when the funds will be required. 

(e) If, after notification, additional funds are not allotted by the end of the period specified in the Schedule or another agreed-upon date, upon the
Contractor’s written request the Contracting Officer will terminate this contract on that date in accordance with the provisions of the Termination clause of this contract. If the Contractor estimates that the funds available will allow it to
continue to discharge its obligations beyond that date, it may specify a later date in its request, and the Contracting Officer may terminate this contract on that later date. 

(f) Except as required by other provisions of this contract, specifically citing and stated to be an exception to this clause— 

(1) The Government is not obligated to reimburse the Contractor for costs incurred in excess of the total amount allotted by the Government to this
contract; and 

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 (2) The Contractor is not obligated to continue performance under this contract (including actions under
the Termination clause of this contract) or otherwise incur costs in excess of (i) the amount then allotted to the contract by the Government or, (ii) if this is a cost-sharing contract, the amount then allotted by the Government to the
contract plus the Contractor’s corresponding share, until the Contracting Officer notifies the Contractor in writing that the amount allotted by the Government has been increased and specifies an increased amount, which shall then constitute
the total amount allotted by the Government to this contract. 
 (g) The estimated cost shall be increased to the extent that (1) the
amount allotted by the Government or, (2) if this is a cost-sharing contract, the amount then allotted by the Government to the contract plus the Contractor’s corresponding share, exceeds the estimated cost specified in the Schedule. If
this is a cost-sharing contract, the increase shall be allocated in accordance with the formula specified in the Schedule. 
 (h) No notice,
communication, or representation in any form other than that specified in subparagraph (f)(2) above, or from any person other than the Contracting Officer, shall affect the amount allotted by the Government to this contract. In the absence of the
specified notice, the Government is not obligated to reimburse the Contractor for any costs in excess of the total amount allotted by the Government to this contract, whether incurred during the course of the contract or as a result of termination.

 (i) When and to the extent that the amount allotted by the Government to the contract is increased, any costs the Contractor incurs before
the increase that are in excess of (1) the amount previously allotted by the Government or, 
 (2) if this is a cost-sharing contract, the
amount previously allotted by the Government to the contract plus the Contractor’s corresponding share, shall be allowable to the same extent as if incurred afterward, unless the Contracting Officer issues a termination or other notice and
directs that the increase is solely to cover termination or other specified expenses. 
 (j) Change orders shall not be considered an
authorization to exceed the amount allotted by the Government specified in the Schedule, unless they contain a statement increasing the amount allotted. 

(k) Nothing in this clause shall affect the right of the Government to terminate this contract. If this contract is terminated, the Government and the
Contractor shall negotiate an equitable distribution of all property produced or purchased under the contract, based upon the share of costs incurred by each. 

(l) If the Government does not allot sufficient funds to allow completion of the work, the Contractor is entitled to a percentage of the fee specified in
the Schedule equalling the percentage of completion of the work contemplated by this contract. 
 (End of clause) 

 

	52.243-7	NOTIFICATION OF CHANGES (APR 1984) 

 (a)
Definitions. 
 “Contracting Officer,” as used in this clause, does not include any representative of the Contracting Officer.

 “Specifically authorized representative (SAR),” as used in this clause, means any person the Contracting Officer has so designated
by written notice (a copy of which shall be provided to the Contractor) which shall refer to this subparagraph and shall be issued to the designated representative before the SAR exercises such authority. 

(b) Notice. The primary purpose of this clause is to obtain prompt reporting of Government conduct that the Contractor considers to constitute a change
to this contract. Except for changes identified as such in writing and 

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signed by the Contracting Officer, the Contractor shall notify the Administrative Contracting Officer in writing, within 15 calendar days from the date that the Contractor identifies any
Government conduct (including actions, inactions, and written or oral communications) that the Contractor regards as a change to the contract terms and conditions. On the basis of the most accurate information available to the Contractor, the notice
shall state— 
 (1) The date, nature, and circumstances of the conduct regarded as a change; 

(2) The name, function, and activity of each Government individual and Contractor official or employee involved in or knowledgeable about such conduct;

 (3) The identification of any documents and the substance of any oral communication involved in such conduct; 

(4) In the instance of alleged acceleration of scheduled performance or delivery, the basis upon which it arose; 

(5) The particular elements of contract performance for which the Contractor may seek an equitable adjustment under this clause, including- 

(i) What contract line items have been or may be affected by the alleged change; 

(ii) What labor or materials or both have been or may be added, deleted, or wasted by the alleged change; 

(iii) To the extent practicable, what delay and disruption in the manner and sequence of performance and effect on continued performance have been or may
be caused by the alleged change; 
 (iv) What adjustments to contract price, delivery schedule, and other provisions affected by the alleged
change are estimated; and 
 (6) The Contractor’s estimate of the time by which the Government must respond to the Contractor’s notice
to minimize cost, delay or disruption of performance. 
 (c) Continued performance. Following submission of the notice required by
(b) above, the Contractor shall diligently continue performance of this contract to the maximum extent possible in accordance with its terms and conditions as construed by the Contractor, unless the notice reports a direction of the Contracting
Officer or a communication from a SAR of the Contracting Officer, in either of which events the Contractor shall continue performance; provided, however, that if the Contractor regards the direction or communication as a change as described in
(b) above, notice shall be given in the manner provided. All directions, communications, interpretations, orders and similar actions of the SAR shall be reduced to writing and copies furnished to the Contractor and to the Contracting Officer.
The Contracting Officer shall countermand any action which exceeds the authority of the SAR. 
 (d) Government response. The Contracting Officer
shall promptly, within 30 calendar days after receipt of notice, respond to the notice in writing. In responding, the Contracting Officer shall either— 

(1) Confirm that the conduct of which the Contractor gave notice constitutes a change and when necessary direct the mode of further performance;

 (2) Countermand any communication regarded as a change; 

(3) Deny that the conduct of which the Contractor gave notice constitutes a change and when necessary direct the mode of further performance; or

 (4) In the event the Contractor’s notice information is inadequate to make a decision under (1), (2), or (3) above, advise the
Contractor what additional information is required, and establish the date by which it should be furnished and the date thereafter by which the Government will respond. 

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 (e) Equitable adjustments. 

(1) If the Contracting Officer confirms that Government conduct effected a change as alleged by the Contractor, and the conduct causes an increase or
decrease in the Contractor’s cost of, or the time required for, performance of any part of the work under this contract, whether changed or not changed by such conduct, an equitable adjustment shall be made— 

(i) In the contract price or delivery schedule or both; and 

(ii) In such other provisions of the contract as may be affected. 

(2) The contract shall be modified in writing accordingly. In the case of drawings, designs or specifications which are defective and for which the
Government is responsible, the equitable adjustment shall include the cost and time extension for delay reasonably incurred by the Contractor in attempting to comply with the defective drawings, designs or specifications before the Contractor
identified, or reasonably should have identified, such defect. When the cost of property made obsolete or excess as a result of a change confirmed by the Contracting Officer under this clause is included in the equitable adjustment, the Contracting
Officer shall have the right to prescribe the manner of disposition of the property. The equitable adjustment shall not include increased costs or time extensions for delay resulting from the Contractor’s failure to provide notice or to
continue performance as provided, respectively, in (b) and (c) above. 
 Note: The phrases “contract price” and
“cost” wherever they appear in the clause, may be appropriately modified to apply to cost-reimbursement or incentive contracts, or to combinations thereof. 

(End of clause) 
  

			
	 52.252-2
	  	CLAUSES INCORPORATED BY REFERENCE (FEB 1998)

 This contract
incorporates one or more clauses by reference, with the same force and effect as if they were given in full text. Upon request, the Contracting Officer will make their full text available. Also, the full text of a clause may be accessed
electronically at this/these address(es): 
 http://farsite.hill.af.mil 

(End of clause) 
  

			
	 52.252-6
	  	AUTHORIZED DEVIATIONS IN CLAUSES (APR 1984)

 (a) The use in
this solicitation or contract of any Federal Acquisition Regulation (48 CFR Chapter 1) clause with an authorized deviation is indicated by the addition of “(DEVIATION)” after the date of the clause. 

(b) The use in this solicitation or contract of any Defense Federal Acquisition Regulations Supplement (48 CFR Chapter 2) clause with an
authorized deviation is indicated by the addition of “(DEVIATION)” after the name of the regulation. 
 (End of clause) 

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	 252.201-9003
	  	LIMITATION OF AUTHORITY (JUN 2009)

 No person in the
Government, other than a Contracting Officer, has the authority to provide direction to the Contractor, which alters the Contractor’s obligations or changes this contract in any way. If any person representing the Government, other than a
Contracting Officer, attempts to alter contract obligations, change the contract specifications/statement of work or tells the contractor to perform some effort which the Contractor believes to be outside the scope of this contract, the Contractor
shall immediately notify the Procuring Contracting Officer (PCO). Contractor personnel shall not comply with any order or direction which they believe to be outside the scope of this contract unless the order or direction is issued by a Contracting
Officer. 
  

			
	 252.203-9004
	  	ETIOLOGIC AGENTS—BIOLOGICAL DEFENSE RESEARCH PROGRAM (FEB 2008)

  

	 	a.	For purpose of this contract etiologic agent—biological defense program is defined as: any viable microorganism, or its toxin which causes or may cause human
disease, including those agents listed in 42 CFR 73, 9 CFR 121, and 7 CFR 331, of the Department of Health and Human Services and Department of Agriculture regulations, respectively, and any agent of biological origin that poses a degree of hazard
to those agents and is further identified by the US Army. The contractor shall comply with the following when working with etiologic agents: 

  

	 	(1)	29 Code of Federal Regulations 1910, Occupational Health and Safety; 

  

	 	(2)	US Department of Health and Human Services (DHHS) and US Department of Agriculture, Select Agent Program(s), 42 CFR 73, 9 CFR 121, and 7 CFR 331; and

  

	 	(3)	DHHS Publication No. 93-8395, Biosafety in Microbiological and Biomedical Laboratories, latest edition. 

 

	 	b.	Etiologic agents shall be packaged, labeled, shipped, and transported in accordance with applicable Federal, State, and local laws and regulations, to include:

  

	 	(1)	42 CFR 72 (Interstate Shipment of Etiologic Agents); 

  

	 	(2)	49 CFR 172 and 173 (Department of Transportation); 

  

	 	(3)	9 CFR 122 (USDA Restricted Animal Pathogens); 

  

	 	(4)	International Air Transport Association Dangerous Goods Regulations; 

  

	 	(5)	The United States Postal Service shall not be used for transportation of BDRP related etiologic agents; and 

 

	 	(6)	If performance is outside of the United States, any additional procedures required by the nation where the work is to be performed. 

252.203-9005, Implementation of Contractor Code of Business Ethics and Conduct (Dec 2008) 

In accordance with FAR clause 52.203-13, Contractor Code of Business Ethics and Conduct, the designated “agency Office of the Inspector General”
is the DoD OIG at the following address: 
 Office of the Inspector General 

United States Department of Defense 

Investigative Policy and Oversight 

 HDTRA1-10-C-004 

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 Contractor Disclosure Program 

400 Army Navy Drive, Suite 1037 

Arlington, VA 22202-4704 

Toll Free Telephone: 866-429-8011 
  

			
	 252.204-9004
	  	IMPLEMENTATION OF DISCLOSURE OF INFORMATION (JUN 2007)

 In
accordance with DFARS 252.204-7000 Disclosure of Information, any information to be released shall be submitted at least 45 days before the proposed release date, for security and policy review. Submit one copy to each below: 

(a) Office of Public Affairs, DTRA/DIR/COS/PA, 8725 John J. Kingman Dr, MS 6201, Ft Belvoir VA 22060-6201. 

(b) Contracting Officer 

(c) Program Manager 

(d) Task Order Manager 

(End of Clause) 
  

			
	 252.209-9002
	  	NON-GOVERNMENT SUPPORT PERSONNEL (JAN 2008)

 The
following companies may have access to contractor information, technical data or computer software that may be marked as proprietary or otherwise marked with restrictive legends: Suntiva LLC (Formerly C-Systems International Corporation )(contract
specialist support); Systems Research and Analysis (SRA, managing JPRAS) and The Tauri Group (Advisory and Assistance Services). Each contract contains organizational conflict of interest provisions and/or includes contractual requirements for
non-disclosure of proprietary contractor information or data/software marked with restrictive legends. The contractor, by submitting a proposal or entering into this contract, is deemed to have consented to the disclosure of its information to
Suntiva LLC, SRA and The Tauri Group under the conditions and limitations described herein. 
  

			
	 252.215-9004
	  	KEY PERSONNEL (FEB 2000)

 The personnel listed below are
considered essential to the work being performed hereunder. Prior to removing, replacing, or diverting any of the specified individuals, the Contractor shall notify the Contracting Officer reasonably in advance and shall submit justification
(including proposed substitutions) in sufficient detail to permit evaluation of the impact on this Contract. No deviation shall be made by the Contractor without the prior written consent of the Contracting Officer; provided, that the Contracting
Officer may ratify in writing the change, such ratification shall constitute the consent of the Contracting Officer required by this paragraph. The personnel listed below may, with the consent of the contracting parties, be amended from time to time
during the course of the Contract to either add or delete personnel as appropriate. 
 Principal Investigator 

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	 252.216-9003
	  	CONSULTANTS (OCT 1998)

 Services of consultants shall be at
rates and for periods approved in advance by the Contracting Officer. Requests for approval shall be submitted to the Contracting Officer sufficiently in advance of the need to use a consultant under this Contract. The request shall include
(a) a copy of the proposed consultant agreement, (b) a brief biography of the consultant, and (c) an indication of the area(s) in which consultant’s expertise will be utilized and why it is essential for contract performance. In
addition, significant deviations from the dollar amount approved for consultant services, or changes in the consultants to be utilized, must likewise be approved in advance upon submission of adequate justification. 

 

			
	 252.227-9000
	  	COMPUTER CODE DEVELOPMENT (OCT 1998)

 Computer code
development (the writing of a new computer program or the enhancement of an existing program to expand its capabilities) even if not explicitly specified in the Tasks of the SOW, shall be accompanied by a report which will be a brief summary
describing the software, associated machine requirements and development and documentation status of each Computer Code for DTRA to determine the applicability of the Computer program to specific research programs. 

 

			
	 252.235-9000
	  	SOURCES OF INFORMATION (JULY 2000)

 a. The results of the
research to be delivered to the Government under this Contract shall embody the most recent reliable information in the field which is available to the Contractor from private and governmental sources, and the Contractor agrees to utilize all
sources of such information available to it. In this connection, information in this field which is in the control of DTRA shall, with the consent of the Contracting Officer’s Representative (COR) and under such safeguards and procedures as
he/she may prescribe, be made available to the Contractor on request. Additionally, the Contractor is encouraged to make use of the resources available through the Defense Threat Reduction Information Analysis Center (DTRIAC), 1680 Texas Street,
Southeast, Kirtland AFB, New Mexico 87117. 
 b. Reasonable assistance in obtaining access to information, or in obtaining permission to use
Government or private facilities, will be given to the Contractor by DTRA. Specifically, the Contractor must register with the Defense Technical Information Center, ATTN: DTIC, 8725 John J. Kingman Road, Suite 0944, Fort Belvoir, VA 22060-6218, in
accordance with Defense Logistics Agency (DLA) Regulation 4185.10, Certification and Registration for Access to DoD Defense Technical Information. DD Form 1540, the registration form, shall be forwarded to the DTRA Contracting Officer for approval
(DFARS 35.010(b)). 
 (End of clause) 
  

			
	 252.235-9001
	  	PROHIBITION OF USE OF LABORATORY ANIMALS (OCT 2008)(DTRA)

 No
animal studies may be conducted using DOD funds until Animal Care and Use Review Office (ACURO) approval has been granted. Studies involving non human primates, dogs, cats, or marine mammals will require a

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site visit by a DoD laboratory animal veterinarian. The recipient (including subcontractors) is expressly forbidden to use laboratory animals in any manner whatsoever without the express written
approval of the US Army Medical Research and Material Command (MRMC), Animal Care and Use Review Office (ACURO). You must complete the ACURO Animal Use Appendix for Research Involving Animals found at the following web site:
https://mrmcwww.army.mil/AnimalAppendix.asp. Please submit the completed ACURO appendix, contact information, the DTRA contract number and a copy of the contract for processing to the email address listed at the ACURO website for processing. You
will receive written approval to begin research under the applicable protocol proposed for this award from the US Army MRMC ACURO under separate email to the recipient and Principal Investigator. A copy of this approval will be provided to the
Defense Threat Reduction Agency (DTRA) for the official file. Noncompliance with any provision of this clause may result in the termination of the award. 
  

			
	 252.242-9000
	  	CONTRACTOR PERFORMANCE ASSESSMENT REPORTING SYSTEM (CPARS) (NOV 2002)

1. As required by FAR Parts 42 and 15, and DTRA policy for the Contractor Performance Assessment Reporting System (CPARS) and Past Performance Information
Retrieval System (PPIRS), formerly known as PPAIS, effective July, 2001, the Government shall complete a CPAR each year of the period of performance of this contract. The contractor will have an opportunity to provide their comments in each CPAR
before it is completed. In accordance with DTRA CPARS policy the completed CPARs will be entered into PPIRS, a retrieval system for Government source selection teams to access the CPARs of contractor’s performance. The DTRA CPARS and PPIRS
policy includes an explanation of the process and procedures that will be utilized under this contract. A copy is available for contractor reference via the DTRAlink (www.dtra.mil) by accessing Acquisition, Doing Business With Us. 

2. The CPARs shall occur annually in accordance with the schedule established below: 

(i) Initial CPAR: 12 months after contract start date (date performance begins) TBD (by PCO) 

(ii) Interim CPAR(s) will be performed annually on the anniversary of the contract start date according to the following schedule: TBD (by PCO)

 (iii) A Final CPAR will be completed upon contract termination, transfer of program management/contract management responsibility outside of
DTRA, the delivery of the final end item on contract and/or the completion of the performance period. 
 (iv) An Out-of-Cycle CPAR may be
required when there is a significant change in performance that alters the assessment in one or more evaluation area(s). An Out-of-Cycle CPAR is optional and shall be processed in accordance with DTRA CPARS policy referenced in paragraph 1. above.

 3. Each CPAR shall only cover the period elapsing from the last annual CPAR. The final CPAR shall not be used to summarize or
“roll-up” the contractor’s performance under the entire contract. Each annual CPAR and the final CPAR together will comprise a total picture of contractor performance. 

4. At the request of the Government, a verbal, informal review of the Contractor’s performance may be held 3-6 months before the completion of the
Interim or Final Evaluation periods. This review entails discussing any problems or areas of concern regarding the Contractor’s performance to date. No written evaluation form or other formal documentation is required for this evaluation. It
may be conducted with the Contractor by telephone, teleconference or face-to-face. This is designed to offer the Contractor an opportunity to correct known deficiencies or weaknesses prior to the formal written evaluation. 

 HDTRA1-10-C-004 

 Page
 34
 of 35 
  

 5. As set forth in DTRA CPARS policy, any disagreements between the Contractor and the Program Manager
regarding the CPAR(s) that cannot be resolved shall be reviewed by the designated Reviewing Official prior to completion of the CPAR. 
 6.
Special Requirements for Indefinite Delivery Contracts (IDIQ and Requirements type), CPARs shall be processed (select one)  

             for all existing orders (combined) at the time the CPAR is processed

              on an order-by-order basis 

             on a grouped order basis 

7. The policy and procedures set forth in this clause and DTRA CPARS policy are not subject to “Disputes” as described in FAR Part 33.

  

			
	 252.245-9000
	  	Government Property (AUG 2009)

 (a) In accordance with
FAR 52.245-1(b), Property Management, and FAR 52.245-1(f), Contractor Plans and Systems, the Contractor shall have a system to manage (control, use, preserve, protect, repair and maintain) Government property in its possession. 

(b) The Contract Data Requirements Lists (CDRLs) associated with the Property for this Contract are contained in Exhibit “A” and included in
Section J of this contract. The spreadsheet required by the CDRL entitled “Master Government Property List (MGPL) will be incorporated in Section J of this contract. 

(c) The Contractor shall provide to the Government an updated MGPL according to the CDRL. 

(d) The Government Site Visits/Physical Inventory – The DTRA will annually verify the Property in the Possession of the Contractor. The
Contactor’s Point of Contact shall coordinate with the Program Manager/Contracting Officer Representative or DTRA Accountable Property Officer (APO) on prearranged site visits upon request. 

(e) The Contractor shall annually conduct and provide to the DTRA a physical inventory report of ALL Government Property in its possession according to
the Master Government Property List (Physical Inventory) CDRL. 
 (f) The physical inventory report shall be validated/confirmed via signature
by both the Contractor’s Property Administrator and the DTRA’s Government Representative (i.e. COR, APO, etc.). Inventory discrepancies must be reported immediately to the Contracting Officer, COR/Program Manager and resolved by the DTRA
APO. 
 (g) The Contractor shall provide all CDRL reports to the Government electronically in a spreadsheet using Microsoft Office Excel. Unless
otherwise specified, the contractor shall submit all data through the IUID Registry. 
 (End of Clause) 

Exhibit/Attachment Table of Contents 

 HDTRA1-10-C-004 

 Page
 35
 of 35 
  

							
	DOCUMENT TYPE	 	DESCRIPTION	 	PAGES	 	DATE
	Exhibit A	 	CDRLS	 		 	09-DEC-2009
	Attachment 1	 	Statement of Work	 		 	30-NOV-2009

 EXHIBIT A 

																																			
	 CONTRACT DATA REQUIREMENTS LIST

 (2 Data items)
	  	
            Form Approved

            OMB No. 0704-0188
	  		  	
	The public reporting burden for this collection of information is estimated to
average 110 hours per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this
burden estimate or any other aspect of this collection of information, including suggestions for reducing the burden, to Department of Defense, Washington Headquarters Services, Directorate for information Operations and Reports (0701-0188), 1215
Jefferson Davis Highway, Suite 1204, Arlington, VA, 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection or information if it does
no display a currently valid OMB control number. Please DO NOT RETURN your form to the above address. Send completed form to the Government Issuing Contracting Officer for the Contract/PR No. Listed in Block E.	  		  	
	
A.  CONTRACT LINE ITEM

NO.
 NA

 
	  	 B. EXHIBIT

 
 A
	  	 C. CATEGORY

 

TDP                      
TM                      OTHER                
      
	  	 	  		  	
	  

D. SYSTEM/ITEM
  

Transformational Medical Tech Initiative
	  	  

E. CONTRACT/PR NO.
	  	F. CONTRACTOR  

                    Trius Therapeutics,
Inc.
  
	  		  	
	 1.
DATA ITEM NO.
  
 A001
	 	 2. TITLE OF DATA ITEM

 
 Work Breakdown Structure

 
	  	 3. SUBTITLE

 
 3-Level Work Breakdown Structure

 
	  	 	  	 17. PRICE GROUP

 
  

	 4. AUTHORITY (Data Acquisition
Document No.)
  
 DI-MGMT-81334C

 
	  	5. CONTRACT REFERENCE  

NA
	  	 6. REQUIRING OFFICE
  

DTRA/TMTI
	  	 	  	 18. ESTIMATED

        TOTAL PRICE

	
7. DD 250 REQ  
  

LT
	  	 9. DIST

 
 STATEMENT

REQUIRED    
  

NA
	  	 10. FREQUENCY

 
         See Blk 16

 
	  	 12. DATE OF FIRST SUBMISSION

 
         See Blk 16

 
	  	14. DISTRIBUTION	  	 	  
	  	  	  	  	a. ADDRESSEE  	  	b. COPIES	  		  	 
	 8. APP
CODE
 A
	  	  	 11. AS OF DATE

 
         See Blk 16

 
	  	 13. DATE OF SUBSEQUENT
SUBMISSION
  
         See Blk
16
  
	  	  	DDraft  	  	Final	  		  	
	  	  	  	  	  	  	Reg  	  	Repro  	  		  	
	
16. REMARKS
  

Three-Level WBS with costs & schedule per each level (top level is program, level 2 is base/options, level 3 are major tasks). For lowest task level
show breakdown for labor, material and other indirect costs. Blk 10-13: First report due 15 days prior to Kick-off as part of Project Management Plan (CDRL A011) submission. To be updated annually. Government may provide acceptable format.
Government review/approval is 15 days after receipt of first submittal. Provide changes to draft within 10 days of such request. Provide final document within 10 days after approval of changes is received.
	  	DTRA/TMTI	  	 	  	1	  	 	  		  	
	  	DTRA/BCR	  	 	  	1	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	15. TOTAL	  	0	  	2	  	0	  		  	
	 1. DATA ITEM NO.

 
 A002

 
	 	 2. TITLE OF DATA ITEM

  
 Monthly Invoice Report

 
	  	 3. SUBTITLE

 
 NA

 
	  	 	  	 17. PRICE GROUP

  
  

	 4. AUTHORITY (Data Acquisition
Document No.)
  
 DI-FNCL-80331A

 
	  	5. CONTRACT REFERENCE  

NA
  
	  	 6. REQUIRING OFFICE
  

DTRA/TMTI
  
	  	 	  	18. ESTIMATED         TOTAL PRICE
	 7. DD
250 REQ
  
 LT

 
	  	 9. DIST

 
 STATEMENT

REQUIRED    
  

NA
  
	  	 10. FREQUENCY

 
 Monthly
	  	 12. DATE OF FIRST SUBMISSION

 
 See Blk 16

 
	  	14. DISTRIBUTION	  	 	  
	  	  	  	  	a. ADDRESSEE  	  	b. COPIES	  		  	 
	 8. APP
CODE
  
 A

 
	  	  	 11. AS OF DATE

 
 See Blk 16

 
	  	 13. DATE OF SUBSEQUENT
SUBMISSION
  
 See Blk 16

 
	  	  	DDraft	  	Final	  		  	
	  	  	  	  	  	  	Reg  	  	Repro	  		  
	
16. REMARKS
  

Summary of invoices submitted during previous month or last month for which unreported data is available. Blk 11-13: Report after first business day of
the month after contract initiation and every month thereafter.
	  	DTRA/TMTI	  	 	  	1	  	 	  		  	
	  	DTRA/BCR	  	 	  	1	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	15. TOTAL	  	0	  	2	  	0	  		  	
	 G. PREPARED BY

 
 /s/ William Jones
	  	 H. DATE

 
 12-14-2009
	  	 I. APPROVED
BY
  
 /s/ Unknown Signatory
	  	 J. DATE

 
 /s/ 12-17-2009
	  		  	

																																			
	 CONTRACT DATA REQUIREMENTS LIST

 (2 Data items)
	  	
            Form Approved

            OMB No. 0704-0188
	  		  	
	The public reporting burden for this collection of information is estimated to
average 110 hours per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this
burden estimate or any other aspect of this collection of information, including suggestions for reducing the burden, to Department of Defense, Washington Headquarters Services, Directorate for information Operations and Reports (0701-0188), 1215
Jefferson Davis Highway, Suite 1204, Arlington, VA, 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection or information if it does
no display a currently valid OMB control number. Please DO NOT RETURN your form to the above address. Send completed form to the Government Issuing Contracting Officer for the Contract/PR No. Listed in Block E.	  		  	
	
A.  CONTRACT LINE ITEM

NO.
 NA

 
	  	 B. EXHIBIT

 
 A
	  	 C. CATEGORY

 

TDP                      
TM                      OTHER                
      
	  	 	  		  	
	  

D. SYSTEM/ITEM
  

Transformational Medical Tech Initiative
  
	  	  

E. CONTRACT/PR NO.
	  	F. CONTRACTOR  

                    Trius Therapeutics,
Inc.
	  		  	
	 1.
DATA ITEM NO.
  
 A003

 
	 	 2. TITLE OF DATA ITEM

 
 Quarterly Status Report

 
	  	 3. SUBTITLE

 
 Quarterly Contract Performance Re

 
	  	 	  	 17. PRICE GROUP

 
  

	 4. AUTHORITY (Data Acquisition
Document No.)
  
 DI-MGMT-80368A

 
	  	5. CONTRACT REFERENCE  

NA
  
	  	 6. REQUIRING OFFICE
  

DTRA/TMTI
  
	  	 	  	 18. ESTIMATED

        TOTAL PRICE

	
7. DD 250 REQ  
  

LT
  
	  	 9. DIST

 
 STATEMENT

REQUIRED    
  

NA
  
	  	 10. FREQUENCY

 
         Quarterly
	  	 12. DATE OF FIRST SUBMISSION

 
         See Blk 16

 
	  	14. DISTRIBUTION	  	 	  
	  	  	  	  	a. ADDRESSEE  	  	b. COPIES	  		  	 
	 8. APP
CODE
  
 A

 
	  	  	 11. AS OF DATE

 
         See Blk 16

 
	  	 13. DATE OF SUBSEQUENT
SUBMISSION
  
         See Blk
16
  
	  	  	DDraft  	  	Final	  		  	
	  	  	  	  	  	  	Reg  	  	Repro  	  		  	
	
16. REMARKS
  

First report due within 15 days after the end of the first Fiscal Quarter (FQ) after award. Subsequent reports due within 15 days of the end of each FQ.
Report will address cost, schedule, performance (including pertinent technical data), and risk, to include updates to project expenditures. The 4th quarterly report for each
FY will include an Executive Summary for the entire FY. Government may provide acceptable format. Government review/approval is 15 days after receipt of first submittal. Provide changes to draft within 10 days of such request. Provide final document
within 10 days after approval of changes is received.
	  	DTRA/TMTI	  	 	  	1	  	 	  		  	
	  	DTRA/BCR	  	 	  	1	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	 	  		 		  		  		  		  		  		  		  		  		  	 	  	15. TOTAL	  	0	  	2	  	0	  		  	
	 1. DATA ITEM NO.

 
 A004

 
	 	 2. TITLE OF DATA ITEM

  
 Integrated Master Schedule

 
	  	 3. SUBTITLE

 
 NA

 
	  	 	  	 17. PRICE GROUP

  
  

	 4. AUTHORITY (Data Acquisition
Document No.)
  
 DI-MGMT-81650

 
	  	5. CONTRACT REFERENCE  

NA
  
	  	 6. REQUIRING OFFICE
  

DTRA/TMTI
  
	  	 	  	18. ESTIMATED         TOTAL PRICE
	 7. DD
250 REQ
  
 LT

 
	  	 9. DIST

 
 STATEMENT

REQUIRED    
  

NA
  
	  	 10. FREQUENCY

 
 See Blk 16

 
	  	 12. DATE OF FIRST SUBMISSION

 
 See Blk 16

 
	  	14. DISTRIBUTION	  	 	  
	  	  	  	  	a. ADDRESSEE  	  	b. COPIES	  		  	 
	 8. APP
CODE
  
 A

 
	  	  	 11. AS OF DATE

 
 See Blk 16

 
	  	 13. DATE OF SUBSEQUENT
SUBMISSION
  
 See Blk 16

 
	  	  	DDraft	  	Final	  		  	
	  	  	  	  	  	  	Reg  	  	Repro	  		  
	
16. REMARKS
  

First report due 15 days prior to Kick-off. Microsoft Project compatible file required. Subsequent updates due within 15 days of each FQ end. Government
may provide acceptable format. Government review/approval is 15 days after receipt of first submittal. Provide changes to draft within 10 days of such request. Provide final document within 10 days after approval of changes is
received.
	  	DTRA/TMTI	  	 	  	1	  	 	  		  	
	  	DTRA/BCR	  	 	  	1	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	 	  		 		  		  		  		  		  		  		  		  		  	 	  	15. TOTAL	  	0	  	2	  	0	  		  	
	 G. PREPARED BY

 
 /s/ William Jones
	  	 H. DATE

 
 12-14-2009
	  	 I. APPROVED
BY
  
 /s/ Unknown Signatory
	  	 J. DATE

 
 /s/ 12-17-2009
	  		  	

																																			
	 CONTRACT DATA REQUIREMENTS LIST

 (2 Data items)
	  	
            Form Approved

            OMB No. 0704-0188
	  		  	
	The public reporting burden for this collection of information is estimated to
average 110 hours per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this
burden estimate or any other aspect of this collection of information, including suggestions for reducing the burden, to Department of Defense, Washington Headquarters Services, Directorate for information Operations and Reports (0701-0188), 1215
Jefferson Davis Highway, Suite 1204, Arlington, VA, 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection or information if it does
no display a currently valid OMB control number. Please DO NOT RETURN your form to the above address. Send completed form to the Government Issuing Contracting Officer for the Contract/PR No. Listed in Block E.	  		  	
	
A.  CONTRACT LINE ITEM

NO.
 NA

 
	  	 B. EXHIBIT

 
 A
	  	 C. CATEGORY

 

TDP                      
TM                      OTHER                
      
	  	 	  		  	
	  

D. SYSTEM/ITEM
  

Transformational Medical Tech Initiative
	  	  

E. CONTRACT/PR NO.
	  	F. CONTRACTOR  

                    Trius Therapeutics,
Inc.
	  		  	
	 1.
DATA ITEM NO.
  
 A005
	 	 2. TITLE OF DATA ITEM

 
 Final Report

 
	  	 3. SUBTITLE

 
 Final Project Report

 
	  	 	  	 17. PRICE GROUP

 
  

	 4. AUTHORITY (Data Acquisition
Document No.)
  
 DI-ADMN-80447A

 
	  	5. CONTRACT REFERENCE  

NA
  
	  	 6. REQUIRING OFFICE
  

DTRA/TMTI
  
	  	 	  	 18. ESTIMATED

        TOTAL PRICE

	
7. DD 250 REQ  
  

LT
	  	 9. DIST

 
 STATEMENT

REQUIRED    
  

NA
  
	  	 10. FREQUENCY

 
         1 Time

 
	  	 12. DATE OF FIRST SUBMISSION

 
         See Blk 16

 
	  	14. DISTRIBUTION	  	 	  
	  	  	  	  	a. ADDRESSEE  	  	b. COPIES	  		  	 
	 8. APP
CODE
  
 A

 
	  	  	 11. AS OF DATE

 
         Project Completion

 
	  	 13. DATE OF SUBSEQUENT
SUBMISSION
  
         See Blk
16
  
	  	  	DDraft  	  	Final	  		  	
	  	  	  	  	  	  	Reg  	  	Repro  	  		  	
	
16. REMARKS
  

Submission within 30 days of completion of final task on contract. Contractor format acceptable. Final report must include final summary of cost/financial
data and project schedule in addition to performance. Government may provide acceptable format. Government review/approval is 15 days after receipt of first submittal. Provide changes to draft within 10 days of such request. Provide final document
within 5 days after approval of changes is received.
	  	DTRA/TMTI	  	 	  	1	  	 	  		  	
	  	DTRA/BCR	  	 	  	1	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	 	  		 		  		  		  		  		  		  		  		  		  	 	  	15. TOTAL	  	0	  	2	  	0	  		  	
	 1. DATA ITEM NO.

 
 A006

 
	 	 2. TITLE OF DATA ITEM

  
 Miscellaneous Data Submissions

 
	  	 3. SUBTITLE

 
 Point papers, briefings, technical presentations and publications

  
	  	 	  	 17. PRICE GROUP

  
  

	 4. AUTHORITY (Data Acquisition
Document No.)
  
 NA

 
	  	5. CONTRACT REFERENCE  

NA
  
	  	 6. REQUIRING OFFICE
  

DTRA/TMTI
  
	  	 	  	18. ESTIMATED         TOTAL PRICE
	 7. DD
250 REQ
  
 LT
	  	 9. DIST

 
 STATEMENT

REQUIRED    
  

NA
  
	  	 10. FREQUENCY

 
 As required

 
	  	 12. DATE OF FIRST SUBMISSION

 
 As required

 
	  	14. DISTRIBUTION	  	 	  
	  	  	  	  	a. ADDRESSEE  	  	b. COPIES	  		  	 
	 8. APP
CODE
  
 A

 
	  	  	 11. AS OF DATE

 
 As required

 
	  	 13. DATE OF SUBSEQUENT
SUBMISSION
  
 As required

 
	  	  	DDraft	  	Final	  		  	
	  	  	  	  	  	  	Reg  	  	Repro	  		  
	
16. REMARKS
  

Submission frequency will average approximately twice per year and dates will be coordinated. Deliverables shall be compatible electronic media. Required
submissions include Point Papers, Briefings, TPP, PDP, ACURO Approvals, HROB Approvals. Unless government format is provided, contractor format is acceptable. Government review/approval is 15 days after receipt of first submittal. Provide changes to
draft within 10 days of such request. Provide final document within 10 days after approval of changes is received.
	  	DTRA/TMTI	  	 	  	1	  	0	  		  	
	  	DTRA/BCR	  	 	  	1	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	 	  		 		  		  		  		  		  		  		  		  		  	 	  	15. TOTAL	  	0	  	2	  	0	  		  	
	 G. PREPARED BY

 
 /s/ William Jones
	  	 H. DATE

 
 12-14-2009
	  	 I. APPROVED
BY
  
 /s/ Unknown Signatory
	  	 J. DATE

 
 /s/ 12-17-2009
	  		  	

																																			
	 CONTRACT DATA REQUIREMENTS LIST

 (2 Data items)
	  	
            Form Approved

            OMB No. 0704-0188
	  		  	
	The public reporting burden for this collection of information is estimated to
average 110 hours per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this
burden estimate or any other aspect of this collection of information, including suggestions for reducing the burden, to Department of Defense, Washington Headquarters Services, Directorate for information Operations and Reports (0701-0188), 1215
Jefferson Davis Highway, Suite 1204, Arlington, VA, 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection or information if it does
no display a currently valid OMB control number. Please DO NOT RETURN your form to the above address. Send completed form to the Government Issuing Contracting Officer for the Contract/PR No. Listed in Block E.	  		  	
	
A.  CONTRACT LINE ITEM

NO.
 NA
	  	 B. EXHIBIT

 
 A
	  	 C. CATEGORY

 

TDP                      
TM                      OTHER                
      
	  	 	  		  	
	
D. SYSTEM/ITEM
  

Transformational Medical Tech Initiative
	  	E. CONTRACT/PR NO.	  	 F. CONTRACTOR

 
             Trius
Therapeutics, Inc.
	  		  	
	 1.
DATA ITEM NO.
  
 A007
	  	 2. TITLE OF DATA ITEM

 
 Patent – Reporting of Subject Inventions
	  	 3. SUBTITLE

 
 NA
	  		  	
17. PRICE GROUP
  

 

	 4.
AUTHORITY (Data Acquisition Document No.)
  

NA
	  	 5. CONTRACT REFERENCE

 
 NA
	  	 6. REQUIRING OFFICE

 
 DTRA/TMTI
	  		  	 18. ESTIMATED

        TOTAL PRICE

	
7. DD 250 REQ
  

LT
	  	 9. DIST

 
 STATEMENT  

REQUIRED      
  

NA
	  	 10. FREQUENCY

 
         Annually
	  	 12. DATE OF FIRST SUBMISSION

 
         See Blk 16
	  	14. DISTRIBUTION	  		  	 
	  	  	  	  	a. ADDRESSEE	  	b. COPIES	  		  	 
	 8. APP CODE

A
	  	  	 11. AS OF DATE

 
         See Blk 16
	  	 13. DATE OF SUBSEQUENT SUBMISSION

 
         See Blk 16
	  	  	DDraft	  	Final	  		  	
	  	  	  	  	  	  	Reg	  	Repro	  		  
	
16. REMARKS
  

Provide report(s) every 12 months from the date of the contracts as identified in the DFARS 252.227-7039 (Patents – Reporting Subject Inventions (DD
Form 882 attached) and FAR 52.227-11.
	  	DTRA/TMTI	  	 	  	1	  	 	  		  	
	  	DTRA/BCR	  	 	  	1	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	15. TOTAL	  	0	  	2	  	0	  		  	
	 1. DATA ITEM NO.

 
 A008
	  	 2. TITLE OF DATA ITEM

  
 Regulatory Approvals and Technical
Data Packages
	  	 3. SUBTITLE

 
 Submission Report (Regulatory Appr. Docs)
	  		  	17. PRICE GROUP
	 4.
AUTHORITY (Data Acquisition Document No.)
  

NA
	  	 5. CONTRACT REFERENCE

 
 NA
	  	 6. REQUIRING OFFICE

 
 DTRA/TMTI
	  		  	18. ESTIMATED         TOTAL PRICE
	 7.
DD 250 REQ
  
 LT
	  	 9. DIST

 
 STATEMENT  

REQUIRED      
  

NA
	  	 10. FREQUENCY

 
 See Blk 16
	  	 12. DATE OF FIRST SUBMISSION

 
 See Blk 16
	  	14. DISTRIBUTION	  		  	 
	  	  	  	  	a. ADDRESSEE	  	b. COPIES	  		  	 
	 8. APP CODE

 
 A
	  	  	 11. AS OF DATE

 
 See Blk 16
	  	 13. DATE OF SUBSEQUENT SUBMISSION

 
 See Blk 16
	  	  	DDraft	  	Final	  		  	
	  	  	  	  	  	  	Reg	  	Repro	  		  
	 16. REMARKS

 
 Contractor will submit pre-IND, and/or pre-EUA to the FDA. Contractor will provide
the Government copies of all technical data generated by the contractor prior to and during performance of contract necessary to pursue FDA approval of pre-IND, IND, or pre-EUA, and notify the Government of FDA decisions. All written communications
to and/or from the FDA will he provided to the Government. Government review is 15 days after receipt of first submittal and will not impede submission of documents to FDA by Contractor.
	  	DTRA/TMTI	  	 	  	1	  	 	  		  	
	  	DTRA/BCR	  	 	  	1	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	15. TOTAL	  	0	  	2	  	0	  		  	
	 G.
PREPARED BY
  
 /s/ William Jones
	  	 H. DATE

 
 12-14-2009
	  	 I. APPROVED BY

 
 /s/ Unknown Signatory
	  	 J. DATE

 
 /s/ 12-17-2009
	  		  	

																																			
	 CONTRACT DATA REQUIREMENTS LIST

 (2 Data items)
	  	
            Form Approved

            OMB No. 0704-0188
	  		  	
	The public reporting burden for this collection of information is estimated to
average 110 hours per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this
burden estimate or any other aspect of this collection of information, including suggestions for reducing the burden, to Department of Defense, Washington Headquarters Services, Directorate for information Operations and Reports (0701-0188), 1215
Jefferson Davis Highway, Suite 1204, Arlington, VA, 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection or information if it does
no display a currently valid OMB control number. Please DO NOT RETURN your form to the above address. Send completed form to the Government Issuing Contracting Officer for the Contract/PR No. Listed in Block E.	  		  	
	
A.  CONTRACT LINE ITEM

NO.
 NA
	  	 B. EXHIBIT

 
 A
	  	 C. CATEGORY

 

TDP                      
TM                      OTHER                
      
	  	 	  		  	
	
D. SYSTEM/ITEM
  

Transformational Medical Tech Initiative
	  	E. CONTRACT/PR NO.	  	 F. CONTRACTOR

 
             Trius
Therapeutics, Inc.
	  		  	
	 1.
DATA ITEM NO.
  
 A009
	  	 2. TITLE OF DATA ITEM

 
 In-Process Review
	  	 3. SUBTITLE

 
 NA
	  		  	
17. PRICE GROUP
  

 

	 4.
AUTHORITY (Data Acquisition Document No.)
  

DI-MGMT-80368A
	  	 5. CONTRACT REFERENCE

 
 NA
	  	 6. REQUIRING OFFICE

 
 DTRA/TMTI
	  		  	 18. ESTIMATED

        TOTAL PRICE

	
7. DD 250 REQ
  

LT
	  	 9. DIST

 
 STATEMENT  

REQUIRED      
  

NA
	  	 10. FREQUENCY

 
         Bianually
	  	 12. DATE OF FIRST SUBMISSION

 
         See Blk 16
	  	14. DISTRIBUTION	  		  	 
	  	  	  	  	a. ADDRESSEE	  	b. COPIES	  		  	 
	 8. APP CODE

A
	  	  	 11. AS OF DATE

 
         See Blk 16
	  	 13. DATE OF SUBSEQUENT SUBMISSION

 
         See Blk 16
	  	  	DDraft	  	Final	  		  	
	  	  	  	  	  	  	Reg	  	Repro	  		  
	
16. REMARKS
  

Contractor present project status formally to the Government no more than every 6 months in accordance with a Government provided agenda. The information
contained in the In Process Review (IPR) is similar to that contained in the Quarterly Status Report (QSR, CDRL A003) but in a presentation format. Unless government format is provided, contractor format is acceptable. Government review/approval is
15 days after receipt of first submittal. Provide changes to draft within 10 days of such request. Provide final document within 10 days after approval of changes is received.
	  	DTRA/TMTI	  	 	  	1	  	 	  		  	
	  	DTRA/BCR	  	 	  	1	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	15. TOTAL	  	0	  	2	  	0	  		  	
	 1. DATA ITEM NO.

 
 A010
	  	 2. TITLE OF DATA ITEM

  
 Expenditure Forecast
	  	 3. SUBTITLE

 
 Project Spend Plan
	  		  	17. PRICE GROUP
	 4.
AUTHORITY (Data Acquisition Document No.)
  

DI-MGMT-81468
	  	 5. CONTRACT REFERENCE

 
 NA
	  	 6. REQUIRING OFFICE

 
 DTRA/TMTI
	  		  	18. ESTIMATED         TOTAL PRICE
	 7.
DD 250 REQ
  
 LT
	  	 9. DIST

 
 STATEMENT  

REQUIRED      
  

NA
	  	 10. FREQUENCY

 
 See Blk 16
	  	 12. DATE OF FIRST SUBMISSION

 
 See Blk 16
	  	14. DISTRIBUTION	  		  	 
	  	  	  	  	a. ADDRESSEE	  	b. COPIES	  		  	 
	 8. APP CODE

 
 A
	  	  	 11. AS OF DATE

 
 See Blk 16
	  	 13. DATE OF SUBSEQUENT SUBMISSION

 
 See Blk 16
	  	  	DDraft	  	Final	  		  	
	  	  	  	  	  	  	Reg	  	Repro	  		  
	 16. REMARKS

 
 Contractor will provide an updated expenditure forecast reflecting actual negotiated
costs over the lifetime of the project 15 days prior to Kick-off, and will update the forecast as requested by the Government. Unless government format is provided, contractor format is acceptable. Government review/approval is 15 days after receipt
of first submittal. Provide changes to draft within 10 days of such request. Provide final document within 10 days after approval of changes is received.
	  	DTRA/TMTI	  	 	  	1	  	 	  		  	
	  	DTRA/BCR	  	 	  	1	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	15. TOTAL	  	0	  	2	  	0	  		  	
	 G.
PREPARED BY
  
 /s/ William Jones
	  	 H. DATE

 
 12-14-2009
	  	 I. APPROVED BY

 
 /s/ Unknown Signatory
	  	 J. DATE

 
 /s/ 12-17-2009
	  		  	

																																			
	 CONTRACT DATA REQUIREMENTS LIST

 (2 Data items)
	  	
            Form Approved

            OMB No. 0704-0188
	  		  	
	The public reporting burden for this collection of information is estimated to
average 110 hours per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this
burden estimate or any other aspect of this collection of information, including suggestions for reducing the burden, to Department of Defense, Washington Headquarters Services, Directorate for information Operations and Reports (0701-0188), 1215
Jefferson Davis Highway, Suite 1204, Arlington, VA, 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection or information if it does
no display a currently valid OMB control number. Please DO NOT RETURN your form to the above address. Send completed form to the Government Issuing Contracting Officer for the Contract/PR No. Listed in Block E.	  		  	
	
A.  CONTRACT LINE ITEM

NO.
 NA
	  	 B. EXHIBIT

 
 A
	  	 C. CATEGORY

 

TDP                      
TM                      OTHER                
      
	  	 	  		  	
	
D. SYSTEM/ITEM
  

Transformational Medical Tech Initiative
	  	E. CONTRACT/PR NO.	  	 F. CONTRACTOR

 
             Trius
Therapeutics, Inc.
	  		  	
	 1.
DATA ITEM NO.
  
 A0011
	  	 2. TITLE OF DATA ITEM

 
 Project Management Plan
	  	 3. SUBTITLE

 
 NA
	  		  	
17. PRICE GROUP
  

 

	 4.
AUTHORITY (Data Acquisition Document No.)
  

DI-MGMT-80004A
	  	 5. CONTRACT REFERENCE

 
 NA
	  	 6. REQUIRING OFFICE

 
 DTRA/TMTI
	  		  	 18. ESTIMATED

        TOTAL PRICE

	
7. DD 250 REQ
  

LT
	  	 9. DIST

 
 STATEMENT  

REQUIRED      
  

NA
	  	 10. FREQUENCY

 
         See Blk 16
	  	 12. DATE OF FIRST SUBMISSION

 
         See Blk 16
	  	 14. DISTRIBUTION
  
	  		  	 
	  	  	  	  	a. ADDRESSEE	  	b. COPIES	  		  	 
	 8. APP CODE

A
	  	  	 11. AS OF DATE

 
         See Blk 16
	  	 13. DATE OF SUBSEQUENT SUBMISSION

 
         See Blk 16
	  	  	DDraft	  	Final	  		  	
	  	  	  	  	  	  	Reg	  	Repro	  		  
	
16. REMARKS
  

Includes organizational chart, initial WBS, initial Integrated Master Plan, Risk Management Plan, and Regulatory Affairs Plan. Due 15 days prior to
Kick-off. Government may provide acceptable format. Government review/approval is 15 days after receipt of first submittal. Provide changes to draft within 10 days of such request. Provide final document within 10 days of such request. Provide final
document within 10 days after approval of changes is received.
	  	DTRA/TMTI	  	 	  	1	  	 	  		  	
	  	DTRA/BCR	  	 	  	1	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	15. TOTAL	  	0	  	2	  	0	  		  	
	 1. DATA ITEM NO.

 
	  	 2. TITLE OF DATA ITEM

  
	  	 3. SUBTITLE

 
	  		  	17. PRICE GROUP
	 4.
AUTHORITY (Data Acquisition Document No.)
  
	  	 5. CONTRACT REFERENCE

 
	  	 6. REQUIRING OFFICE

 
	  		  	 18. ESTIMATED
        TOTAL PRICE
  

	 7.
DD 250 REQ
  
	  	 9. DIST

 
 STATEMENT  

REQUIRED      

 
	  	 10. FREQUENCY

 
	  	 12. DATE OF FIRST SUBMISSION

 
	  	14. DISTRIBUTION	  		  	 
	  	  	  	  	a. ADDRESSEE	  	b. COPIES	  		  	 
	 8. APP CODE

 
	  	  	 11. AS OF DATE

 
	  	 13. DATE OF SUBSEQUENT SUBMISSION

 
	  	  	DDraft	  	Final	  		  	
	  	  	  	  	  	  	Reg	  	Repro	  		  
	16. REMARKS	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	15. TOTAL	  	 	  	 	  	 	  		  	
	 G.
PREPARED BY
  
 /s/ William Jones
	  	 H. DATE

 
 12-14-2009
	  	 I. APPROVED BY

 
 /s/ Unknown Signatory
	  	 J. DATE

 
 /s/ 12-17-2009
	  		  	

																																			
	 CONTRACT DATA REQUIREMENTS LIST

 (2 Data items)
	  	
            Form Approved

            OMB No. 0704-0188
	  		  	
	The public reporting burden for this collection of information is estimated to
average 110 hours per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this
burden estimate or any other aspect of this collection of information, including suggestions for reducing the burden, to Department of Defense, Washington Headquarters Services, Directorate for information Operations and Reports (0701-0188), 1215
Jefferson Davis Highway, Suite 1204, Arlington, VA, 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection or information if it does
no display a currently valid OMB control number. Please DO NOT RETURN your form to the above address. Send completed form to the Government Issuing Contracting Officer for the Contract/PR No. Listed in Block E.	  		  	
	
A.  CONTRACT LINE ITEM

NO.
 NA
	  	 B. EXHIBIT

 
 A
	  	 C. CATEGORY

 

TDP                      
TM                      OTHER                
      
	  	 	  		  	
	
D. SYSTEM/ITEM
  

Transformational Medical Tech Initiative
	  	E. CONTRACT/PR NO.	  	 F. CONTRACTOR

 
 Trius Therapeutics, Inc.

 
	  		  	
	 1.
DATA ITEM NO.
  
 A012
	  	 2. TITLE OF DATA ITEM

 
 Master Government Property List
	  	 3. SUBTITLE

 
 GFP, GFE, GFM and Contractor Acquired Property
	  		  	
17. PRICE GROUP
  

 

	 4.
AUTHORITY (Data Acquisition Document No.)
  

DI-MGMT-80269
	  	 5. CONTRACT REFERENCE

 
 NA
	  	 6. REQUIRING OFFICE

 
 DTRA/BE-BL_
	  		  	 18. ESTIMATED

        TOTAL PRICE

	
7. DD 250 REQ
  

LT
	  	 9. DIST

 
 STATEMENT  

REQUIRED      
  

NA
	  	 10. FREQUENCY

 
 Monthly
	  	 12. DATE OF FIRST SUBMISSION

 
 See Blk 16
	  	14. DISTRIBUTION	  		  	 
	  	  	  	  	a. ADDRESSEE	  	b. COPIES	  		  	 
	 8. APP CODE

A
	  	  	 11. AS OF DATE

 
 Award
	  	 13. DATE OF SUBSEQUENT SUBMISSION

 
 See Blk 16
	  	  	DDraft	  	Final	  		  	
	  	  	  	  	  	  	Reg	  	Repro	  		  
	 16. REMARKS

 
 Block 4: This DID is for reference only. The report shall be prepared according to
the remarks below.
 Block 12: 45th calendar day following contract
award.
 Block 13: Tenth calendar day of each month.
  

During performance of the Contract, the Contractor may purchase material or equipment using Government funds [Contractor Acquired Property (CAP)] if it is
approved by the Contracting Officer. The Contractor shall provide a Master Government Property List (MGPL) inclusive of all CAP on the 45th calendar day following Contract
award and the tenth calendar day of each subsequent month.
  
 The MGPL shall
include all equipment/property provided to the contract, including equipment transferred between projects, broken and obsolete equipment, and items purchased outside the United States. The MGPL shall consist of the following data elements at a
minimum: Accountable Contract, Property Name, Original Manufacturer’s Name, Description/Commercial Use, Original Manufacturer’s Part Number, Model Number, Serial Number, DTRA Asset ID Number, Equipment Identification Number Quantity,
Contract to which equipment is assigned, Work Breakdown Structure Project Number, Item Unique Identifier or equivalent, Project Descriptor, Equipment Location, Date Placed In Service, Condition of Property (active, stored, in-transit or waiting
disposal), Government Property Type (Government Furnished Equipment, Government Furnished Material, Government Furnished Property, CAP), Unit Acquisition Cost (from accounting system) and Remarks.

 
 The MGPL shall be delivered electronically in a spreadsheet using Microsoft Office
Excel. Abbreviations are not allowed.
  
 Ninety (90) days prior to Contract
expiration, the Contractor shall submit a final MGPL suitable for close-out purposes containing use/disposition recommendations.
  
	  	DTRA/BE-BL_	  	 	  	 	  	1	  		  	
	  	DTRA/BE-BF_	  	 	  	 	  	1	  		  	
	  	DTRA/BE-BC_	  	 	  	 	  	1	  		  	
	  	DTRA/TMTI	  	 	  	 	  	1	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 15. TOTAL

 
  
	  	 	  	 	  	4  

 
	  		  	
	 G.
PREPARED BY
  
 /s/ William Jones
	  	 H. DATE

 
 12-14-2009
	  	 I. APPROVED BY

 
 /s/ Unknown Signatory
	  	 J. DATE

 
 /s/ 12-17-2009
	  		  	

																																			
	 CONTRACT DATA REQUIREMENTS LIST

 (2 Data items)
	  	
            Form Approved

            OMB No. 0704-0188
	  		  	
	The public reporting burden for this collection of information is estimated to
average 110 hours per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this
burden estimate or any other aspect of this collection of information, including suggestions for reducing the burden, to Department of Defense, Washington Headquarters Services, Directorate for information Operations and Reports (0701-0188), 1215
Jefferson Davis Highway, Suite 1204, Arlington, VA, 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection or information if it does
no display a currently valid OMB control number. Please DO NOT RETURN your form to the above address. Send completed form to the Government Issuing Contracting Officer for the Contract/PR No. Listed in Block E.	  		  	
	
A.  CONTRACT LINE ITEM

NO.
 NA
	  	 B. EXHIBIT

 
 A
	  	 C. CATEGORY

 

TDP                      
TM                      OTHER                
      
	  	 	  		  	
	
D. SYSTEM/ITEM
  

Transformational Medical Tech Initiative
	  	E. CONTRACT/PR NO.	  	 F. CONTRACTOR

 
 Trius Therapeutics, Inc.
	  		  	
	
1. DATA ITEM NO.
  

A013
	  	 2. TITLE OF DATA ITEM

 
 Master Government Property – Physical Inventory
	  	 3. SUBTITLE

 
 GFP, GFE, GFM and Contractor Acquired Property
	  		  	
17. PRICE GROUP
  

 

	 4.
AUTHORITY (Data Acquisition Document No.)
  

DI-MGMT-80441
	  	 5. CONTRACT REFERENCE

 
 NA
	  	 6. REQUIRING OFFICE

 
 DTRA/BE-BL_
	  		  	 18. ESTIMATED

TOTAL PRICE

	
7. DD 250 REQ
  

LT
	  	 9. DIST

STATEMENT
 REQUIRED

 
 NA
	  	 10. FREQUENCY

 
 Annually
	  	 12. DATE OF FIRST SUBMISSION

 
 One Month after award
	  	14. DISTRIBUTION	  		  	 
	  	  	  	  	a. ADDRESSEE	  	b. COPIES	  		  	 
	 8. APP CODE

A
	  	  	 11. AS OF DATE

 
 Award
	  	 13. DATE OF SUBSEQUENT SUBMISSION

 
 Annually
	  	  	DDraft	  	Final	  		  	
	  	  	  	  	  	  	Reg	  	Repro	  		  
	 16. REMARKS

 
 Block 4: This DID is for reference only. The report shall be prepared according to
the remarks below.
  
 The Contractor shall annually perform, record and
disclose physical inventory results of all Government Property/Contractor Acquired Property (CAP)/Equipment/Material. A final coordinated physical inventory shall be performed upon contract completion or termination and approved by the DTRA
Accountable Property Officer.
  
 The Physical Inventory Report shall
indentify the Contractor’s Point of Contact with telephone number and signature and shall consist of the following data elements at a minimum: Accountable Contract, Property Name, Original Manufacturer’s Name, Description/Commercial Use,
Original Manufacturer’s Part Number, Model Number, Serial Number, DTRA Asset ID Number, Equipment Identification Number Quantity, Contract to which equipment is assigned, Work Breakdown Structure Project Number, Item Unique Identifier or
equivalent, Project Descriptor, Equipment Location, Date Placed In Service, Condition of Property (active, stored, in-transit or waiting disposal), Government Property Type (Government Furnished Equipment, Government Furnished Material, Government
Furnished Property, CAP), Unit Acquisition Cost (from accounting system) and Remarks.
  

The Physical Inventory Report shall be documented in writing and validated/confirmed by both the Contractor’s Property Administrator and the DTRA PM.
Inventory discrepancies must be reported immediately to the Contracting Officer, PM or the DTRA Accountable Property Officer. The report shall contain original signatures and be delivered electronically in a spreadsheet using Microsoft Office Excel.
Abbreviations are not allowed.
  
 Ninety (90) days prior to Contract
expiration, the Contractor shall submit a final property identification listing suitable for close-out purposes containing use/disposition recommendations. The report must be reviewed, approved and signed by the DTRA Accountable Property Officer
prior to contract close out.
	  	DTRA/BE-BL_	  	 	  	 	  	1	  		  	
	  	DTRA/BE-BF_	  	 	  	 	  	1	  		  	
	  	DTRA/BE-BC_	  	 	  	 	  	1	  		  	
	  	DTRA/TMTI	  	 	  	 	  	1	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	15. TOTAL	  	 	  	 	  	4	  		  	
	  	 	  	 	  	 	  		  		  	
	  	 	  	 	  	 	  		  		  	
	  	 	  	 	  	 	  	 	  		  	
	 G.
PREPARED BY
  
 /s/ William Jones
	  	 H. DATE

 
 12-14-2009
	  	 I. APPROVED BY

 
 /s/ Unknown Signatory
	  	 J. DATE

 
 /s/ 12-17-2009
	  		  	

 SCHEDULE 1 

 

 
  

 Broad Spectrum Antibacterial Therapeutics from Marine Natural Products

 TMTI-DRUG-02: Trius Therapeutics 

Statement of Work 
 1.0–
Objective: The goal of this program is to develop a safe, potent antimicrobial agent derived from marine sediment actinomycete fermentations. The agent will have a novel, bacterial-specific mechanism of action for the prophylaxis and treatment
of infectious diseases caused by Category A and B bacterial pathogens. We will maximize the opportunity for rapid progress by collecting and fermenting novel actinomycetes from a novel resource, marine sediments. We will minimize the time for
discovery of novel mechanism antibacterials using our unique collection of Bacillus anthracis antisense strains hypersensitized to [...***...] different bacterial-specific essential targets. We will accelerate development of
therapeutics from these discoveries using our structural biology platform to co-crystallize the natural products with the protein targets, thus allowing semi-synthetic modification to optimize the drug properties. [...***...]. The resulting
therapeutics will show no cross-resistance to existing drugs and a broad pathogen spectrum. Thus, we mitigate the defense threat and aid the warfighter by providing a unique, cost-effective solution to counter multiple possible bacterial biowarfare
agents with a single therapeutic agent. 
 2.0 – Scope: This proposal to develop therapeutic countermeasures against Category A and
B bacterial pathogens is in support of the Defense Threat Reduction Agency (DTRA) Chemical and Biological Defense Medical S&T Division research and development program. The scope of work for this contract falls into the following 4 stages:
[...***...] Time frames are shown below with more details of the Base period, Option Periods and Option Tasks outlined in Attachment 1. 

In Option Task 1, [...***...]. 

It is anticipated that [...***...]. However, the other studies [...***...] compound. DTRA has [...***...] and
[...***...], to be triggered at the discretion of DTRA (see figure below). 
  

					
	V03.31.10	 	1	 	***Confidential Treatment Requested

 

 

  

 Period of Contract and Budget 

[...***...] 
 3.0 – Background:

 Bioweapons derived from bacterial pathogens are a serious and present danger to the warfighter. The nature of these bacterial bioweapons
will require therapeutics with novel mechanisms of action because of the likelihood that such bioweapons will be engineered for resistance against 

 

					
	V03.31.10	 	2	 	***Confidential Treatment Requested

 

 

  

 
known therapeutics. New antibacterial therapeutics to address this danger are not currently in development. The reality of the danger combined with the paucity of new therapeutics creates a
strong urgency for a rapid process with a high likelihood of success. Bacteria of the subgroup Actinomycetales have been the most prolific source of new antibiotics, providing more than 80% of the antibiotic drugs in use today. The method of
discovering antibacterials from soil-derived actinomycetes is well established and includes fermenting the bacteria to elicit production of secondary metabolites, extraction of the resulting broth and then testing for antibacterial activity. Because
of the long effort by countless numbers of researchers examining terrestrial soil, it is increasingly difficult to find novel antibacterials from this source with properties useful in addressing the biowarfare pathogens contemplated here.

 While the search for antimicrobials from the soil-based milieu has reached a point of diminishing returns, recent
advances in marine microbiology have opened unprecedented opportunities for the discovery of useful new antibiotics from ocean sediment microorganisms. [...***...] 

The Base period milestone is [...***...]. The goal of Option Period 1 is [...***...] into Option 2
(preclinical), where the milestone is [...***...]. Up to [...***...] studies. [...***...]. 
 4.0-
Tasks/ Technical Requirements: 
 BASE PERIOD 1 (18 months): [...***...] 

4.0 The contractor should [...***...]. 

The contractor shall [...***...]. 
  

					
	V03.31.10	 	3	 	***Confidential Treatment Requested

 

 

  

 Option Task 4.1: [...***...]. 

4.1 The contractor shall [...***...]. 

4.2 The contractor shall [...***...]. 

4.3 The contractor shall [...***...]. 

[...***...] 

GOAL: [...***...]. 

BASE PERIOD INTERIM MILESTONE ([...***...]): The contractor should [...***...]. 

BASE PERIOD INTERIM MILESTONE ([...***...]): The contractor should [...***...]. 

4.4 The contractor should [...***...]. 

4.4.1 The contractor should [...***...] 

4.4.2 The contractor should [...***...] 

4.4.3 The contractor should [...***...] 

4.4.4 The contractor should [...***...] 

4.5 The contractor should characterize the activity of the isolated components 

[...***...] 
  

					
	V03.31.10	 	4	 	***Confidential Treatment Requested

 

 

  

 [...***...] 

4.6. The contractor should [...***...] 

BASE PERIOD MILESTONE [...***...]. 

[...***...]. 

[...***...]. 
 OPTION PERIOD
1 [...***...] 
 4.7. The contractor [...***...] 

4.8. The contractor should [...***...] 
  

					
	V03.31.10	 	5	 	***Confidential Treatment Requested

 

 

  

 4.9. The contractor should [...***...] 

4.9.1 The contractor should [...***...] 

4.9.2 The contractor should [...***...] 

OPTION 1 INTERIM MILESTONE: The contractor should [...***...]. 

OPTION 1 INTERIM MILESTONE: The contractor should [...***...]. 

OPTION 1 MILESTONE: The contractor should [...***...]. 

OPTION 1 MILESTONE: The contractor should [...***...] 

OPTION PERIOD 2 [...***...] 

4.10. The contractor shall [...***...] 
  

					
	V03.31.10	 	6	 	***Confidential Treatment Requested

 

 

  

 [...***...] 

OPTION PERIOD 2 MILESTONE: The contractor should [...***...] 

] 
 OPTION PERIOD
[...***...] 
 4.12. The contractor shall [...***...] 

4.13. The contractor should [...***...] 

4.14. The contractor shall [...***...] 

4.15. The contractor shall [...***...] 

4.16 The contractor should [...***...] 

OPTION PERIOD 3 MILESTONE: [...***...] 
  

					
	V03.31.10	 	7	 	***Confidential Treatment Requested

 

 

  

 The contractor [...***...] 

OPTION PERIOD 3 [...***...] 

ALL BASE AND OPTION PERIODS 

FY1-FY5 
 Management 

4.19. The contractor shall 

[...***...] 
 4.20.
[...***...] 
 4.21: The contractor shall [...***...] 

5.0- CDRLs/Other deliverables: 
  

	1.	The contractor shall [...***...] 

  

	2.	The contractor shall [...***...] 

  

					
	V03.31.10	 	8	 	***Confidential Treatment Requested

 

 

  

	3.	The contractor shall [...***...] 

  

	4.	The contractor shall [...***...] 

  

	 	a.	The contractor shall [...***...] 

  

	 	b.	The contractor shall [...***...] 

  

	5.	The contractor shall [...***...] 

  

	6.	The contractor shall [...***...] 

  

	7.	The contractor shall [...***...] 

  

	8.	The contractor shall [...***...] 

  

	9.	The contractor shall [...***...] 

  

	10.	The contractor shall [...***...] 

Attachment 1: SUMMARY OF TASKS/TECHNICAL REQUIREMENTS 
  

					
	V03.31.10	 	9	 	***Confidential Treatment Requested

 

 

  

 [...***...] 

 

					
	V03.31.10	 	10	 	***Confidential Treatment Requested

 

 

  

 [...***...] 

 

					
	V03.31.10	 	11	 	***Confidential Treatment Requested

 Attachment 2: CONTRACT DATA REQUIREMENT LIST 

 

																																			
	 CONTRACT DATA REQUIREMENTS LIST

 (2 Data Items)
	  	 Form Approved

OMB No. 0704-0188
	  		  	
	The public reporting burden for this collection of information is estimated to
average 220 hours per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this
burden estimate or any other aspect of this collection of information, including suggestions for reducing the burden, to the Department of Defense, Executive Services Directorate (0704-0188). Respondents should be aware that notwithstanding any
other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. Please do not return your form to the above organization. Send
completed forms to the Government Issuing Contracting Officer for the Contract/PR No. listed in Block E.	  		  	
	
A.  CONTRACT LINE ITEM
 NO.

 NA
	  	 B. EXHIBIT

 
 A
	  	 C. CATEGORY:
  

TDP                      
TM                      OTHER                
      
	  	 	  		  	
	 D.
SYSTEM/ITEM
  
 Chemical/Biological Medical System
	  	E. CONTRACTOR/PR NO.	  	 F. CONTRACTOR

 
 Trius Therapeutics
	  		  	
	 1.
DATA ITEM NO.
  
 A001
	  	 2. TITLE OF DATA ITEM

 
 Work Breakdown Structure
	  	 3. SUBTITLE

 
 3-Level Work Breakdown Structure
	  		  	
17. PRICE GROUP
  

 

	 4.
AUTHORITY (Data Acquisition Document No.)
  

DI-MGMT-81334C
	  	 5. CONTRACT REFERENCE

 
 NA
	  	 6. REQUIRING OFFICE

 
 DTRA/TMTI
	  		  	 18. ESTIMATED

TOTAL PRICE

	
7. DD 250 REQ
  

LT
	  	 9. DIST STATEMENT REQUIRED

 
 NA
	  	 10. FREQUENCY

 
         See Blk 16
	  	 12. DATE OF FIRST SUBMISSION

 
         See Blk 16
	  	14. DISTRIBUTION	  		  	 
	  	  	  	  	a. ADDRESSEE	  	b. COPIES	  		  	 
	 8. APP CODE

A
	  	  	 11. AS OF DATE

 
         See Blk 16
	  	 13. DATE OF SUBSEQUENT SUBMISSION

 
         See Blk 16
	  	  	Draft	  	Final	  		  	
	  	  	  	  	  	  	Reg	  	Repro	  		  
	
16. REMARKS
  

3-Level WBS with costs & schedule per each level. For lowest task level show breakdown for labor, material and other indirect costs. Blk 10-13: First
report due 15 days past award. Formal provided to contractor. To be updated annually. Government review/approval is 15 days after receipt of first submittal. Provide changes to draft within 10 days of such request. Provide final document within 10
days after approval of changes is received.
	  	DTRA/TMTI	  	 	  	1	  	 	  		  	
	  	DTRA/BCR	  	 	  	1	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	15. TOTALg	  	0	  	2	  	0	  		  	
	 1. DATA ITEM NO.

 
 A002
	  	 2. TITLE OF DATA ITEM

  
 Monthly Invoice Report
	  	 3. SUBTITLE

 
 NA
	  		  	17. PRICE GROUP
	 4.
AUTHORITY (Data Acquisition Document No.)
  

DI-FNCL-80331A
	  	 5. CONTRACT REFERENCE

 
 NA
	  	 6. REQUIRING OFFICE

 
 DTRA/TMTI
	  		  	18. ESTIMATED TOTAL PRICE
	 7.
DD 250 REQ
  
 LT
	  	 9. DIST STATEMENT REQUIRED

 
 NA
	  	 10. FREQUENCY

 
 Monthly
	  	 12. DATE OF FIRST SUBMISSION

 
 See Blk 16
	  	14. DISTRIBUTION	  		  	 
	  	  	  	  	a. ADDRESSEE	  	b. COPIES	  		  	 
	 8. APP CODE

 
 A
	  	  	 11. AS OF DATE

 
 See Blk 16
	  	 13. DATE OF SUBSEQUENT SUBMISSION

 
 See Blk 16
	  	  	Draft	  	Final	  		  	
	  	  	  	  	  	  	Reg	  	Repro	  		  
	 16. REMARKS

 
 Summary of invoices submitted during previous month or last month for which
unreported data is available Format provided to contractor. Blk 11-13 Report after first business day of the month after contract award and every month thereafter.
	  	DTRA/TMTI	  	 	  	1	  	 	  		  	
	  	DTRA/BCR	  	 	  	1	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	15. TOTALg	  	0	  	2	  	0	  		  	
	 G.
PREPARED BY
  
 /s/ William Jones
	  	 H. DATE

 
 June 25, 2009
	  	 I. APPROVED BY
	  	 J. DATE

 
	  		  	

																	
	  DD FORM 1423-2, AUG 96	  	PREVIOUS EDITION MAY BE USED.	  		  	 Page      of      Pages

Adobe Professional 7.0
	  	

  

					
	V03.31.10	 	12	 	

																																			
	 CONTRACT DATA REQUIREMENTS LIST

 (2 Data Items)
	  	
            Form Approved

            OMB No. 0704-0188
	  		  	
	The public reporting burden for this collection of information is estimated to
average 220 hours per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this
burden estimate or any other aspect of this collection of information, including suggestions for reducing the burden, to the Department of Defense, Executive Services Directorate (0704-0188). Respondents should be aware that notwithstanding any
other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. Please do not return your form to the above organization. Send
completed forms to the Government Issuing Contracting Officer for the Contract/PR No. listed in Block E.	  		  	
	
A.  CONTRACT LINE ITEM NO.

NA
	  	 B. EXHIBIT

 
 A
	  	 C. CATEGORY:
  

TDP                      
TM                      OTHER                
      
	  	 	  		  	
	 D.
SYSTEM/ITEM
  
 Chemical/Biological Medical System
	  	E. CONTRACTOR/PR NO.	  	 F. CONTRACTOR

 
 Trius Therapeutics

 
	  		  	
	 1.
DATA ITEM NO.
  
 A003
	  	 2. TITLE OF DATA ITEM

 
 Quarterly Status Report
	  	 3. SUBTITLE

 
 Quarterly Contract Performance Report

 
	  		  	17. PRICE GROUP
	 4.
AUTHORITY (Data Acquisition Document No.)
  

DI-ADMN-80447
	  	 5. CONTRACT REFERENCE

 
 NA
	  	 6. REQUIRING OFFICE

 
 DTRA/TMTI
	  		  	 18. ESTIMATED

TOTAL PRICE

	
7. DD 250 REQ
  

LT
	  	 9. DIST STATEMENT REQUIRED

 
 NA
	  	 10. FREQUENCY

 
         Quarterly
	  	 12. DATE OF FIRST SUBMISSION

 
         See Blk 16
	  	14. DISTRIBUTION	  		  	 
	  	  	  	  	a. ADDRESSEE	  	b. COPIES	  		  	 
	 8. APP CODE

 
 A
	  	  	 11. AS OF DATE

 
         See Blk 16
	  	 13. DATE OF SUBSEQUENT SUBMISSION

 
         See Blk 16
	  	  	Draft	  	Final	  		  	
	  	  	  	  	  	  	Reg	  	Repro	  		  
	
16. REMARKS
  

Blks 11-13: First report due within 15 days after the end of the first Fiscal Quarter post award. Subsequent reports due within 15 days of the end of each
FQ. Format provided to the contractor. Government review/approval is 15 days after receipt of first submittal. Provide changes to draft within 10 days of such request. Provide final document within 10 days after approval of changes is
received.
	  	DTRA/TMTI	  	 	  	1	  	 	  		  	
	  	DTRA/BCR	  	 	  	1	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	15. TOTALg	  	0	  	2	  	0	  		  	
	 1. DATA ITEM NO.

 
 A004
	  	 2. TITLE OF DATA ITEM

  
 Quarterly Financial Status Report
	  	 3. SUBTITLE

 
 NA
	  		  	17. PRICE GROUP
	 4.
AUTHORITY (Data Acquisition Document No.)
  

DI-FNCL-80331A
	  	 5. CONTRACT REFERENCE

 
 NA
	  	 6. REQUIRING OFFICE

 
 DTRA/TMTI
	  		  	18. ESTIMATED TOTAL PRICE
	 7.
DD 250 REQ
  
 LT
	  	 9. DIST STATEMENT REQUIRED

 
 NA
	  	 10. FREQUENCY

 
 Quarterly
	  	 12. DATE OF FIRST SUBMISSION

 
 See Blk 16
	  	14. DISTRIBUTION	  		  	 
	  	  	  	  	a. ADDRESSEE	  	b. COPIES	  		  	 
	 8. APP CODE

 
 A
	  	  	 11. AS OF DATE

 
 See Blk 16
	  	 13. DATE OF SUBSEQUENT SUBMISSION

 
 See Blk 16
	  	  	Draft	  	Final	  		  	
	  	  	  	  	  	  	Reg	  	Repro	  		  
	 16. REMARKS

 
 Blks 11-13: First report due within 15 days after the end of the first Fiscal Quarter
post award. Subsequent reports due within 15 days of the end of each FQ. Format provided to the contractor. Report should include expenditures to each item in the 3-Level WBS. Government review/approval is 15 days after receipt of first submittal.
Provide changes to draft within 10 days of such request. Provide final document within 10 days after approval of changes is received.
	  	DTRA/TMTI	  	 	  	1	  	 	  		  	
	  	DTRA/BCR	  	 	  	1	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	15. TOTALg	  	0	  	2	  	0	  		  	
	 G.
PREPARED BY
  
 /s/ William Jones
	  	 H. DATE

 
 June 25, 2009
	  	 I. APPROVED BY

 
	  	 J. DATE

 
	  		  	

																	
	  DD FORM 1423-2, AUG 96	  	PREVIOUS EDITION MAY BE USED.	  		  	Page      of      Pages	  	

  

					
	V03.31.10	 	13	 	

 Adobe Professional
7.0                                         
     

																																			
	 CONTRACT DATA REQUIREMENTS LIST

 (2 Data Items)
	  	
            Form Approved

            OMB No. 0704-0188
	  		  	
	The public reporting burden for this collection of information is estimated to
average 220 hours per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this
burden estimate or any other aspect of this collection of information, including suggestions for reducing the burden, to the Department of Defense, Executive Services Directorate (0704-0188). Respondents should be aware that notwithstanding any
other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. Please do not return your form to the above organization. Send
completed forms to the Government Issuing Contracting Officer for the Contract/PR No. listed in Block E.	  		  	
	
A.  CONTRACT LINE ITEM NO.

NA
	  	 B. EXHIBIT

 
 A
	  	 C. CATEGORY:
  

TDP                      
TM                      OTHER                
      
	  	 	  		  	
	 D.
SYSTEM/ITEM
  
 Chemical/Biological Medical System
	  	E. CONTRACTOR/PR NO.	  	 F. CONTRACTOR

 
 Trius Therapeutics, Inc.

 
	  		  	
	 1.
DATA ITEM NO.
  
 A005
	  	 2. TITLE OF DATA ITEM

 
 Annual Report
	  	 3. SUBTITLE

 
 Cumulative Annual Progress Report

 
	  		  	17. PRICE GROUP
	 4.
AUTHORITY (Data Acquisition Document No.)
  

DI-ADMN-80447
	  	 5. CONTRACT REFERENCE

 
 NA
	  	 6. REQUIRING OFFICE

 
 DTRA/TMTI
	  		  	 18. ESTIMATED

TOTAL PRICE

	
7. DD 250 REQ
  

LT
	  	 9. DIST STATEMENT REQUIRED

 
 NA
	  	 10. FREQUENCY

 
         See Blk 16
	  	 12. DATE OF FIRST SUBMISSION

 
         See Blk 16
	  	14. DISTRIBUTION	  		  	 
	  	  	  	  	a. ADDRESSEE	  	b. COPIES	  		  	 
	 8. APP CODE

 
 A
	  	  	 11. AS OF DATE

 
         See Blk 16
	  	 13. DATE OF SUBSEQUENT SUBMISSION

 
         See Blk 16
	  	  	Draft	  	Final	  		  	
	  	  	  	  	  	  	Reg	  	Repro	  		  
	
16. REMARKS
  

Blks 10-13: First submission within 15 days after the end of the first Fiscal Year following award. Subsequent reports due within 15 days after the end of
the Fiscal Year. Format as provided to contractor. Government review/approval is 15 days after receipt of first submittal. Provide changes to draft within 10 days of such request. Provide final document within 10 days after approval of changes is
received.
	  	DTRA/TMTI	  	 	  	1	  	 	  		  	
	  	DTRA/BCR	  	 	  	1	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	15. TOTALg	  	0	  	2	  	0	  		  	
	 1. DATA ITEM NO.

 
 A006
	  	 2. TITLE OF DATA ITEM

  
 Integrated Master Schedule
	  	 3. SUBTITLE

 
 NA
	  		  	17. PRICE GROUP
	 4.
AUTHORITY (Data Acquisition Document No.)
  

DI-MGMT-81650
	  	 5. CONTRACT REFERENCE

 
 NA
	  	 6. REQUIRING OFFICE

 
 DTRA/TMTI
	  		  	18. ESTIMATED TOTAL PRICE
	 7.
DD 250 REQ
  
 LT
	  	 9. DIST STATEMENT REQUIRED

 
 NA
	  	 10. FREQUENCY

 
 See Blk 16
	  	 12. DATE OF FIRST SUBMISSION

 
 See Blk 16
	  	14. DISTRIBUTION	  		  	 
	  	  	  	  	a. ADDRESSEE	  	b. COPIES	  		  	 
	 8. APP CODE

 
 A
	  	  	 11. AS OF DATE

 
 See Blk 16
	  	 13. DATE OF SUBSEQUENT SUBMISSION

 
 See Blk 16
	  	  	Draft	  	Final	  		  	
	  	  	  	  	  	  	Reg	  	Repro	  		  
	 16. REMARKS

 
 Blk 10-13: First report due 15 days past award. Format provided to contractor.
Subsequent reports due within 15 days of FQ end. Government review/approval is 15 days after receipt of first submittal. Provide changes to draft within 10 days of such request. Provide final document within 10 days after approval of changes is
received.
	  	DTRA/TMTI	  	 	  	1	  	 	  		  	
	  	DTRA/BCR	  	 	  	1	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	15. TOTALg	  	0	  	2	  	0	  		  	
	 G.
PREPARED BY
  
 /s/ William Jones
	  	 H. DATE

 
 June 25, 2009
	  	 I. APPROVED BY

 
	  	 J. DATE

 
	  		  	

																	
	  DD FORM 1423-2, AUG 96	  	PREVIOUS EDITION MAY BE USED.	  		  	 Page      of      Pages

Adobe Professional 7.0
	  	

  

					
	V03.31.10	 	14	 	

																																			
	 CONTRACT DATA REQUIREMENTS LIST

 (2 Data Items)
	  	
            Form Approved

            OMB No. 0704-0188
	  		  	
	 The public reporting burden for
this collection of information is estimated to average 220 hours per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of
information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing the burden, to the Department of Defense, Executive Services Directorate (0704-0188). Respondents
should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. Please do not return your
form to the above organization. Send completed forms to the Government Issuing Contracting Officer for the Contract/PR No. listed in Block E.
	  		  	
	
A.  CONTRACT LINE ITEM NO.
  

NA
	  	 B. EXHIBIT

 
 A
	  	 C. CATEGORY:

 

TDP                      
TM                      OTHER                
      
	  	 	  		  	
	 D.
SYSTEM/ITEM
  
 Chemical/Biological Medical System
	  	E. CONTRACTOR/PR NO.	  	F. CONTRACTOR  

                    Trius
Therapeutics
	  		  	
	 1.
DATA ITEM NO.
  
 A007
	 	 2. TITLE OF DATA ITEM

 
 Final Report

 
	  	 3. SUBTITLE

 
 Final Project Report

 
	  	 	  	 17. PRICE GROUP

 
  

	
4. AUTHORITY (Data Acquisition Document No.)

 
 DI-ADMN-084478

 
	  	5. CONTRACT REFERENCE  

NA
	  	 6. REQUIRING OFFICE
  

DTRA/TMTI
	  	 	  	 18. ESTIMATED

        TOTAL PRICE

	
7. DD 250 REQ
  

LT
	  	 9. DIST

STATEMENT
 REQUIRED

 
 NA
	  	 10. FREQUENCY

 
         1 Time
	  	 12. DATE OF FIRST SUBMISSION

 
         See Blk 16
	  	14. DISTRIBUTION	  	 	  
	  	  	  	  	a. ADDRESSEE	  	b. COPIES	  		  	 
	 8. APP
CODE
 A
	  	  	 11. AS OF DATE

 
         Project End
	  	 13. DATE OF SUBSEQUENT
SUBMISSION
  

        NA
	  	  	Draft	  	Final	  		  	
	  	  	  	  	  	  	Reg	  	Repro	  		  	
	
16. REMARKS
  

Blk 12: Submission within 15 days of completion of final task. Contractor format acceptable. Final report must include final summary of cost/financial
data and project schedule in addition to performance. Government review/approval is 15 days after receipt of first submittal. Provide final document within 10 days of such request. Provide final document within 10 days after approval of changes is
received.
	  	DTRA/TMTI	  	 	  	1	  	 	  		  	
	  	DTRA/BCR	  	 	  	1	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	15. TOTAL g	  	0	  	2	  	0	  		  	
	  	 	  	 	  	 	  		  		  	
	 1. DATA ITEM NO.

 
 A008
	 	 2. TITLE OF DATA ITEM

  
 Miscellaneous Data Submission

 
	  	 3. SUBTITLE

 
 Point Papers, Briefings, TPP, PDP,

Technical Presentations and Publications
  
	  	 	  	 17. PRICE GROUP

  
  

	 4. AUTHORITY (Data Acquisition
Document No.)
  
 NA

 
	  	5. CONTRACT REFERENCE  

NA
  
	  	 6. REQUIRING OFFICE
  

DTRA/TMTI
	  	 	  	18. ESTIMATED         TOTAL PRICE
	 7. DD
250 REQ
  
 LT
	  	 9. DIST

STATEMENT
 REQUIRED

 
 NA
	  	 10. FREQUENCY

 
 As Required
	  	 12. DATE OF FIRST SUBMISSION

 
 As Required
	  	14. DISTRIBUTION	  	 	  
	  	  	  	  	a. ADDRESSEE	  	b. COPIES	  		  	 
	 8. APP
CODE
  
 A
	  	  	 11. AS OF DATE

 
 As Required
	  	 13. DATE OF SUBSEQUENT
SUBMISSION
  
 As Required
	  	  	Draft	  	Final	  		  	
	  	  	  	  	  	  	Reg	  	Repro	  		  
	
16. REMARKS
  

Submission frequencies and dates will be coordinated. Deliverables shall be compatible electronic media. Unless format is provided, contractor format is
acceptable. Required submissions include Point Papers, Briefings, TPP, PDP, ACURO Approvals, HROB Approvals, Technical Presentations and Publications. Government review/approval is 15 days after receipt of first submittal. Provide changes to draft
within 10 days of such request. Provide final document within 10 days after approval of changes is received.
	  	DTRA/TMTI	  	 	  	1	  	 	  		  	
	  	DTRA/BCR	  	 	  	1	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	15. TOTAL g	  	0	  	2	  	0	  		  	
	 G. PREPARED BY

 
 /s/ William Jones
	  	 H. DATE

 
 June 25, 2009
	  	 I. APPROVED
BY
  
	  	 J. DATE

 
	  		  	
	    DD FORM 1423-2, AUG 96
	  	PREVIOUS EDITION MAY BE USED.	  		  	
Page      of      Pages

Adobe Professional 7.0
	  		  	

  

					
	V03.31.10	 	15	 	

																																			
	 CONTRACT DATA REQUIREMENTS LIST

 (2 Data Items)
	  	
            Form Approved

            OMB No. 0704-0188
	  		  	
	 The public reporting burden for
this collection of information is estimated to average 220 hours per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of
information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing the burden, to the Department of Defense, Executive Services Directorate (0704-0188). Respondents
should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. Please do not return your
form to the above organization. Send completed forms to the Government Issuing Contracting Officer for the Contract/PR No. listed in Block E.
	  		  	
	
A.  CONTRACT LINE ITEM NO.
  

NA
	  	 B. EXHIBIT

 
 A
	  	 C. CATEGORY:

 

TDP                      
TM                      OTHER                
      
	  	 	  		  	
	 D.
SYSTEM/ITEM
  
 Chemical/Biological Medical System
	  	E. CONTRACTOR/PR NO.	  	F. CONTRACTOR  

                    Trius
Therapeutics
	  		  	
	 1.
DATA ITEM NO.
  
 A009
	 	 2. TITLE OF DATA ITEM

 
 Patents – Reporting of
Subject    
 Inventions
  
	  	 3. SUBTITLE

 
 NA

 
	  	 	  	 17. PRICE GROUP

 
  

	
4. AUTHORITY (Data Acquisition Document No.)

 
 DI-MISC-80711A

 
	  	5. CONTRACT REFERENCE  

NA
	  	 6. REQUIRING OFFICE
  

DTRA/TMTI
	  	 	  	 18. ESTIMATED

        TOTAL PRICE

	
7. DD 250 REQ  
  

LT
	  	 9. DIST STATEMENT
REQUIRED    
  
 NA
	  	 10. FREQUENCY

 
         Annually
	  	 12. DATE OF FIRST SUBMISSION

 
         See Blk 16
	  	14. DISTRIBUTION	  	 	  
	  	  	  	  	a. ADDRESSEE  	  	b. COPIES	  		  	 
	 8. APP
CODE
 A
	  	  	 11. AS OF DATE

 
         See Blk 16
	  	 13. DATE OF SUBSEQUENT
SUBMISSION
  
         See Blk
16
	  	  	Draft  	  	Final	  		  	
	  	  	  	  	  	  	Reg  	  	Repro  	  		  	
	
16. REMARKS
  

Blk 11-13: Provide report(s) every 12 months from the date of the contract as identified in the DFARS 252.227-7039 (Patents – Reporting Subject
Inventions (DD Form 882 attached) and FAR 52.227-11.
	  	DTRA/TMTI	  	 	  	1	  	 	  		  	
	  	DTRA/BCR	  	 	  	1	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	15. TOTAL g	  	0	  	2	  	0	  		  	
	  	 	  	 	  	 	  		  		  	
	 1. DATA ITEM NO.

 
 A010
	 	 2. TITLE OF DATA ITEM

  
 Regulatory Approval and Technical Data
Packages
  
	  	 3. SUBTITLE

 
 Submission Report (Regulatory Appr. Docs)

 
	  	 	  	 17. PRICE GROUP

  
  

	
4. AUTHORITY (Data Acquisition Document No.)

 
 NA

 
	  	5. CONTRACT REFERENCE  

NA
  
	  	 6. REQUIRING OFFICE
  

DTRA/TMTI
	  	 	  	18. ESTIMATED         TOTAL PRICE
	 7. DD
250 REQ
  
 LT
	  	 9. DIST STATEMENT
REQUIRED    
  
 NA
	  	 10. FREQUENCY

 
 See Blk 16
	  	 12. DATE OF FIRST SUBMISSION

 
 See Blk 16
	  	14. DISTRIBUTION	  	 	  
	  	  	  	  	a. ADDRESSEE  	  	b. COPIES	  		  	 
	 8. APP
CODE
  
 A
	  	  	 11. AS OF DATE

 
 See Blk 16
	  	 13. DATE OF SUBSEQUENT
SUBMISSION
  
 See Blk 16
	  	  	Draft	  	Final	  		  	
	  	  	  	  	  	  	Reg  	  	Repro	  		  
	
16. REMARKS
  

Blk 10-13: Contractor will provide the Government copies of all technical data generated by the contractor prior to and during performance of contract
necessary to pursue FDA approval of IND, NDA, and notify the Government of FDA decisions. All written communications to and/or from the FDA will be provided to the Government. Government review/approval is 15 days after receipt of first submittal.
Provide changes to draft within 10 days of such request. Provide final document within 10 days after approval of changes is received.
	  	DTRA/TMTI	  	 	  	1	  	 	  		  	
	  	DTRA/BCR	  	 	  	1	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	15. TOTAL g	  	0	  	2	  	0	  		  	
	 G. PREPARED BY

 
 /s/ William Jones
	  	 H. DATE

 
 June 25, 2009
	  	 I. APPROVED
BY
  
	  	 J. DATE

 
	  		  	
	    DD FORM 1423-2, AUG 96
	  	PREVIOUS EDITION MAY BE USED.	  		  	
Page      of      Pages

Adobe Professional 7.0
	  		  	

  

					
	V03.31.10	 	16	 	

																																			
	 CONTRACT DATA REQUIREMENTS LIST

 (2 Data Items)
	  	
            Form Approved

            OMB No. 0704-0188
	  		  	
	 The public reporting burden for
this collection of information is estimated to average 220 hours per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of
information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing the burden, to the Department of Defense, Executive Services Directorate (0704-0188). Respondents
should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. Please do not return your
form to the above organization. Send completed forms to the Government Issuing Contracting Officer for the Contract/PR No. listed in Block E.
	  		  	
	
A.  CONTRACT LINE ITEM NO.
  

NA
	  	 B. EXHIBIT

 
 A
	  	 C. CATEGORY:

 

TDP                      
TM                      OTHER                
      
	  	 	  		  	
	 D.
SYSTEM/ITEM
  
 Chemical/Biological Medical System
	  	E. CONTRACTOR/PR NO.	  	F. CONTRACTOR  

                    Trius
Therapeutics
	  		  	
	 1.
DATA ITEM NO.
  
 A011
	 	 2. TITLE OF DATA ITEM

 
 In Process Review

 
	  	 3. SUBTITLE

 
 NA

 
	  	 	  	 17. PRICE GROUP

 
  

	 4. AUTHORITY (Data Acquisition
Document No.)
  
 DI-MGMT-80227 &
DI-MGMT-80555A
  
	  	5. CONTRACT REFERENCE  

NA
	  	 6. REQUIRING OFFICE
  

DTRA/TMTI
	  	 	  	 18. ESTIMATED

        TOTAL PRICE

	
7. DD 250 REQ
  

LT
	  	 9. DIST

STATEMENT
 REQUIRED

 
 NA
	  	 10. FREQUENCY

 
 every 6 months
	  	 12. DATE OF FIRST SUBMISSION

 
         See Blk 16
	  	14. DISTRIBUTION	  	 	  
	  	  	  	  	a. ADDRESSEE	  	b. COPIES	  		  	 
	 8. APP
CODE
 A
	  	  	 11. AS OF DATE

 
         See Blk 16
	  	 13. DATE OF SUBSEQUENT
SUBMISSION
  
         See Blk
16
	  	  	Draft	  	Final	  		  	
	  	  	  	  	  	  	Reg	  	Repro	  		  	
	
16. REMARKS
  

Blk 11-13: Contractor present project status formally to the Government every 6 months in accordance with a Government provided agenda. Government
review/approval is 15 days after receipt of first submittal. Provide changes to draft within 10 days of such request. Provide final document within 10 days after approval of changes is received.
	  	DTRA/TMTI	  	 	  	1	  	 	  		  	
	  	DTRA/BCR	  	 	  	1	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	15. TOTAL g	  	0	  	2	  	0	  		  	
	  	 	  	 	  	 	  		  		  	
	 1. DATA ITEM NO.

 
 A012
	 	 2. TITLE OF DATA ITEM

  
 Expenditure Forecast

 
	  	 3. SUBTITLE

 
 Project Spend Plan

 
	  	 	  	 17. PRICE GROUP

  
  

	 4. AUTHORITY (Data Acquisition
Document No.)
  
 DI-MGMT-81468

 
	  	5. CONTRACT REFERENCE  

NA
  
	  	 6. REQUIRING OFFICE
  

DTRA/TMTI
	  	 	  	18. ESTIMATED         TOTAL PRICE
	 7. DD
250 REQ
  
 LT
	  	 9. DIST

STATEMENT
 REQUIRED

 
 NA
	  	 10. FREQUENCY

 
 See Blk 16
	  	 12. DATE OF FIRST SUBMISSION

 
 See Blk 16
	  	14. DISTRIBUTION	  	 	  
	  	  	  	  	a. ADDRESSEE	  	b. COPIES	  		  	 
	 8. APP
CODE
  
 A
	  	  	 11. AS OF DATE

 
 See Blk 16
	  	 13. DATE OF SUBSEQUENT
SUBMISSION
  
 See Blk 16
	  	  	Draft	  	Final	  		  	
	  	  	  	  	  	  	Reg	  	Repro	  		  
	
16. REMARKS
  

Blks 10-13: Contractor will provide an updated expenditure forecast reflecting actual negotiated costs over the lifetime of the project 15 days past
award, and will update the forecast as requested by the Government. Format as provided to contractor. Government review/approval is 15 days after receipt of first submittal. Provide changes to draft within 10 days of such requesT. Provide final
document within 10 days after approval of changes is received.
	  	DTRA/TMTI	  	 	  	1	  	 	  		  	
	  	DTRA/BCR	  	 	  	1	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	15. TOTAL g	  	0	  	2	  	0	  		  	
	 G. PREPARED BY

 
 /s/ William Jones
	  	 H. DATE

 
 June 25, 2009
	  	 I. APPROVED
BY
  
	  	 J. DATE

 
	  		  	
	    DD FORM 1423-2, AUG 96
	  	PREVIOUS EDITION MAY BE USED.	  		  	
Page      of      Pages

Adobe Professional 7.0
	  		  	

  

					
	V03.31.10	 	17	 	

																																			
	 CONTRACT DATA REQUIREMENTS LIST

 (1 Data Item)
	  	
            Form Approved

            OMB No. 0704-0188
	  		  	
	 The public reporting burden for
this collection of information is estimated to average 220 hours per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of
information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing the burden, to the Department of Defense, Executive Services Directorate (0704-0188). Respondents
should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. Please do not return your
form to the above organization. Send completed forms to the Government Issuing Contracting Officer for the Contract/PR No. listed in Block E.
	  		  	
	
A.  CONTRACT LINE ITEM NO.
  

NA
	  	 B. EXHIBIT

 
 A
	  	 C. CATEGORY:

 

TDP                      
TM                      OTHER                
      
	  	 	  		  	
	 D.
SYSTEM/ITEM
  
 Chemical/Biological Medical System
	  	 E. CONTRACTOR/PR NO.

 
 NA
	  	F. CONTRACTOR  

                    Trius
Therapeutics
	  		  	
	 1.
DATA ITEM NO.
  
 A013
	 	 2. TITLE OF DATA ITEM

 
 Project Management Plan

 
	  	 3. SUBTITLE

 
 NA

 
	  	 	  	 17. PRICE GROUP

 
  

	
4. AUTHORITY (Data Acquisition Document No.)

 
 DI-MGMT-80004A

 
	  	5. CONTRACT REFERENCE  

NA
	  	 6. REQUIRING OFFICE
  

DTRA/TMTI
	  	 	  	 18. ESTIMATED

        TOTAL PRICE

	
7. DD 250 REQ  
  

LT
	  	 9. DIST STATEMENT REQUIRED

 
 NA
	  	 10. FREQUENCY

 
         See Blk 16
	  	 12. DATE OF FIRST SUBMISSION

 
         See Blk 16
	  	14. DISTRIBUTION	  	 	  
	  	  	  	  	a. ADDRESSEE  	  	b. COPIES	  		  	 
	 8. APP
CODE
 A
	  	  	 11. AS OF DATE

 
         See Blk 16
	  	 13. DATE OF SUBSEQUENT
SUBMISSION
  
         See Blk
16
	  	  	Draft  	  	Final	  		  	
	  	  	  	  	  	  	Reg  	  	Repro  	  		  	
	
16. REMARKS
  

Includes organizational chart, initial WBS, initial Integrated Master Plan, Risk Management Plan, Regulatory Affairs Plan. Formats provided to contractor.
Due within 15 days past award.
	  	DTRA/TMTI	  	 	  	1	  	 	  		  	
	  	DTRA/BCR	  	 	  	1	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	 	  	 	  	 	  	 	  		  	
	  	15. TOTAL g	  	0	  	2	  	0	  		  	
	  	 	  	 	  	 	  		  		  	
	 G. PREPARED BY

 
 /s/ William Jones
	  	 H. DATE

 
 June 25, 2009
	  	 I. APPROVED
BY
  
	  	 J. DATE

 
	  		  	
	    DD FORM 1423-2, AUG 96
	  	PREVIOUS EDITION MAY BE USED.	  		  	
Page      of      Pages

Adobe Professional 7.0
	  		  	

  

					
	V03.31.10	 	18

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