Document:

Exhibit 10.21

 

Certain identified information has been excluded from the exhibit pursuant to Item 601(a)(6) of Regulation
S-K due to personal privacy concerns. Redacted information is indicated by: [***]

 

Use this form for all non-U.S. Persons (date: April 13, 2018)

 

PROMIS NEUROSCIENCES INC.

SUBSCRIPTION AGREEMENT

FOR

NON-U.S. PERSONS

 

	
    HAVE YOU COMPLETED THIS SUBSCRIPTION AGREEMENT PROPERLY?

    The following items in this Subscription Agreement must be
completed. (Please initial each box.)

	 
	 	 	 Provide information and answers in the boxes on pages 1, 2 and 3.
	 
	 	 	Sign the execution page on page 1 of this Subscription Agreement. 
	 
	 	 	 Complete Schedule “1” Accredited Investor Representation Letter and sign
	 
	 	 	 

 

Delivery of Subscription forms may be made
by

 

email to: [***], with a copy
to [***]

 

facsimile to: fax #: [***]

 

Delivery of
certified cheque, money order or bank draft may be made by courier/mail to:

 

ProMIS Neurosciences Inc. Attention: CFO

1920 Yonge Street, Suite 200, Toronto, ON M4S 3E2

 

Alternatively, delivery of funds may also be made via electronic
wire transfer in accordance with the wire transfer instructions set forth below:

 

To wire Canadian $ funds:

 

Beneficiary Bank: [***]

Bank Address: [***]

Account # [***]

Bank #:[***]

SWIFT Code: [***]

Currency: [***]

Beneficiary: PROMIS NEUROSCIENCES INC.

Beneficiary address: 1920 Yonge Street, Suite 200, Toronto, ON M4S
3E2

 

If you wish to wire funds in currency other than CDN$, please
contact the Corporation by email: [***]

____________________________________________________________________

 

     

     

    

 

SUBSCRIPTION FOR UNITS

 

	TO:	ProMIS Neurosciences Inc. (the “Corporation”)

 

The undersigned (the “Subscriber”, including, if applicable, each Disclosed Principal (as hereinafter defined) for
whom the undersigned is acting hereunder) hereby irrevocably subscribes for and agrees to purchase the number of units of the Corporation
(the “Units”) set forth below for the aggregate subscription amount set forth below (the “Aggregate Subscription
Amount”), representing a subscription price of CDN$0.375 per Unit, on the terms and conditions set forth in “Terms
and Conditions of Subscription for Units of ProMIS Neurosciences Inc..” attached hereto (together with the face pages and the attached
Schedules, the “Subscription Agreement”). Each Unit consists of one common share of the Corporation (a “Common
Share”) and one-half of a transferable share purchase warrant (a “Warrant”).

 

Each whole Warrant entitles the holder to purchase
one Common Share (a “Warrant Share”) at any time for a five year period, subject to acceleration (as noted below),
at a price of CDN$0.48 per Warrant Share. At any time after the expiry of the four month hold period applicable to the Warrants,
the Corporation may accelerate the expiry of the Warrants if the twenty-day volume-weighted average trading price of the Common Shares
on the TSX, and/or such other exchange on which the Common Shares may be listed, is greater than CDN$1.00 (the “Trigger
Event”) provided that (a) the Corporation gives notice of the same in writing to the holder of the Warrants, and (b) the accelerated
expiry date is a date which is not less than 30 calendar days after the date of such notice. For greater certainty, the twenty-day volume-weighted
average trading price of the Common Shares shall be calculated by dividing the total value by the total volume of Common Shares traded
(on all exchanges, including the TSX and such other exchange on which the Common Shares may be listed) for the twenty trading days immediately
preceding the date of the Trigger Event.

 

The Units, the Common Shares, the Warrants and
the Warrant Shares are hereinafter referred to together as the “Securities”.

 

	
     

    Number of Units:                                                                              

     
	
     

    Aggregate Subscription Amount:
    CDN$                                                                 

     

	Name and Signature of Subscriber	 
	Individual Subscriber 	 	Non-Individual Subscriber (e.g., Corporation)	 
	 	 	 	 
	(Print Name of Individual Subscriber) 	 	(Print Name of Non-Individual Subscriber) 	 
	 	 	 	 
	(Signature of Individual Subscriber) 	 	(Signature of Authorized Signatory) 	 
	 	 	 	 
	 	 	(Print Name and Official Capacity or Title of Signatory)

                                                                                The
signatory represents that he has authority to bind the Subscriber. 
	 
	
    ONLY IF the Subscriber is signing as agent or trustee
    for a principal (a “Disclosed Principal”) and is not purchasing as trustee or agent for accounts fully managed by it, so as
    to be deemed to be purchasing as principal pursuant to National Instrument 45-106, complete the following and, if applicable, ensure that
    all Schedules are completed on behalf of such Disclosed Principal:

     

    _____________________________________________________________________________________________

    (Name of Disclosed Principal and, if Disclosed Principal is not an individual, of the contact person of Disclosed Principal)

    

    

     

    _____________________________________________________________________________________________

    (Address and Telephone Number of Disclosed Principal or, if Disclosed Principal is not an individual, of the contact person of Disclosed
    Principal)

     
	 
	 	 	 	 	 

 

    Page 1

     

    

 

	Address of Subscriber - Residential for Individual / Business for Non-Individual Subscriber
	 	 	 
	Address of Subscriber 	 	(Telephone Number) 
	 	 	 
	City, Province, Postal Code 	 	(Facsimile Number) 
	 	 	 
	 	 	(Email address) 

 

 

	
    REGISTRATION INSTRUCTIONS

      
	 	DELIVERY INSTRUCTIONS
	
    Register the Common Shares and Warrants as set forth below
    (only complete if different from above):

     

     

                                                                                                                                                

    (Name)

     

                                                                                                                                                

    (Account reference, if applicable)

     

                                                                                                                                                

    (Address)

     

                                                                                                                                                
	 	
    Deliver the Common Shares and Warrants as set forth below:

     

     

     

                                                                                                                                                

    (Name)

     

                                                                                                                                                

    (Account reference, if applicable)

     

                                                                                                                                                

    (Contact Name)

     

                                                                                                                                                

    (Address)

     

                                                                                                                                                 

     

 

INFORMATION REGARDING THE SUBSCRIBER

 

Please check the appropriate box (and complete
the required information, if applicable) in each section:

 

	1.	Security Holdings. Prior to giving effect to the issuance of the securities being subscribed for
under this Subscription Agreement, the Subscriber and all persons acting jointly and in concert with the Subscriber currently own, directly
or indirectly, or exercise control or direction over (provide additional detail as applicable):
	 	 
	 	  ̈	_________________ common shares of the Corporation and the following other kinds of rights and convertible securities (including but
not limited to convertible debt, warrants and options) entitling the Subscriber to acquire additional common shares of the Corporation:
	 	 	 
	 	 	 
	 	 	 
	 	  ̈	No shares of the Corporation
or rights or securities convertible into shares of the Corporation.

 

    Page 2

     

    

 

	2.	Insider Status. The Subscriber either:
	 	 

 ̈           Is an “Insider”
of the Corporation as defined in the Policies of the Exchange (as hereinafter defined) by virtue of being:

 

		(a)	a director or executive officer of the Corporation;

		(b)	a director or executive officer of a company that is an Insider or subsidiary of the Corporation;

		(c)	a person that beneficially owns or controls, directly or indirectly, voting shares of the Corporation
carrying more than 10% of the voting rights attached to all the Corporation’s outstanding voting shares; or

		(d)	the Corporation itself if it holds any of its own securities.

 

 ̈
           Is not an Insider of the Corporation.

 

	3.	Pro Group Status. The Subscriber either:
	 	 

 ̈
           Is a Member of the “Pro Group”, which is defined in the Rules of the Exchange as either individually or as a group:

 

		1.	the member (i.e. a member of the Exchange under the Exchange requirements);

		2.	employees of the member;

		3.	partners, officers and directors of the member;

		4.	affiliates of the member;

		5.	such other persons as the Exchange may determine; and

		6.	associates of any parties referred to in paragraphs 1 through 5 above.

 

 ̈
           Is not a member of the Pro Group.

 

	4.	Registrant Status. The Subscriber either:
	 	 
	 	 ̈ 	Is a “Registrant” as defined in the Securities Act (British Columbia) by virtue of being a person registered or required
to be registered under the Securities Act (British Columbia.
	 	 
	 	 ̈ 	Is not a Registrant.

 

    Page 3

     

    

 

ACCEPTANCE:                The Corporation hereby accepts
the subscription as set forth above on the terms and conditions contained in this Subscription Agreement.

 

	                                 ,
  2018.	 
	 	 
	PROMIS NEUROSCIENCES INC.	 
	 	 
	By:	                           	 

 

    Page 4

     

    

 

TERMS AND CONDITIONS OF SUBSCRIPTION FOR

UNITS OF PROMIS NEUROSCIENCES INC.

 

Terms of the Offering

 

1.                             The
Subscriber acknowledges (on its own behalf and, if applicable, on behalf of each person on whose behalf the Subscriber is contracting)
that this subscription is subject to acceptance or rejection by the Corporation, in its sole and absolute discretion, in whole or in
part. The parties agree that this Subscription and all money tendered herewith will be returned to the Subscriber, without interest or
deduction, if this Subscription is not accepted by the Corporation.

 

2.                             The
Subscriber acknowledges (on its own behalf and, if applicable, on behalf of each person on whose behalf the Subscriber is contracting)
that:

 

(a)            the
Corporation is offering (the “Offering”) the Units on a private placement basis under the terms of this Subscription
Agreement;

 

(b)            notwithstanding
section 2(a) above, this Offering will not in any way restrict the Corporation from issuing additional securities of the Corporation
at prices, on terms and in amounts as may be determined by the Corporation, in its sole and absolute discretion, including an amendment
to the Offering to increase the size of the Offering; and

 

(c)            the
issuance of the Units shall be subject to any conditions that may be imposed by the Exchange as part of the Exchange’s acceptance
of the Offering, including, without limitation, in the event that the issuance of the Units hereunder may result in, or be part of a
transaction that may result in:

 

(i)               the issuance of listed Shares representing more than 25% of the number of Shares which are outstanding on a non-diluted basis prior
to the Closing (the “25% Dilution Rule”);

 

(ii)              the
issuance of listed Shares during any six month period to insiders representing more than 10% of the number of Shares which are outstanding
on a non-diluted basis prior to the Closing (the “10% Insider Rule”); or

 

(iii)             the
issuance of listed Shares that will materially affect control of the Corporation.

 

Representations and Warranties of the Corporation

 

3.                             The
Corporation hereby represents and warrants to the Subscriber (and acknowledges that the Subscriber is relying thereon) that:

 

(a)           The Corporation is a duly amalgamated and validly subsisting corporation under the laws of Canada and has full corporate power
and authority to perform each of its obligations as herein contemplated.

 

(b)           The Corporation is listed on the TSX (the “Exchange”) and as a result is subject to the rules and policies of
the Exchange.

 

(c)           The
Corporation is a “reporting issuer” in good standing under the securities laws of the provinces of Ontario, British Columbia
and Alberta.

 

(d)           This
Subscription Agreement, when accepted by the Corporation, will constitute a legal, valid and binding obligation of the Corporation enforceable
in accordance with its terms.

 

(e)           The execution and delivery of, and the performance of the terms of this Subscription Agreement by the Corporation, including the
issue of the Securities, does not and will not constitute a breach of or default under the constating documents of the Corporation or
any law, regulation, order or ruling applicable to the Corporation or any agreement, contract or indenture to which the Corporation is
a party or by which it is bound.

 

    Page 5

     

    

 

(f)            The Corporation is not a party to any actions, suits or proceedings which could materially affect its business or financial condition,
and, as at the date hereof, no such actions, suits or proceedings have been threatened or, to the best of the Corporation’s knowledge,
are pending, except as disclosed in information which has been filed by the Corporation with the various Canadian securities commissions
under applicable securities legislation and the Exchange.

 

(g)           The sale, issuance and delivery of the Units at the closing (the “Closing”) will have been approved by all requisite
corporate action on or before the Closing Date and, upon issue and delivery at the Closing, the Units will be validly issued as fully
paid and non-assessable.

 

(h)           No
order ceasing or suspending trading in the Securities nor prohibiting sale of the Securities has been issued to and is outstanding against
the Corporation or its directors, officers or promoters and to the best of the Corporation’s knowledge no investigations or proceedings
for such purposes are pending or threatened.

 

Acknowledgements, Warranties and Covenants of the Subscriber

 

4.                             The
Subscriber acknowledges, warrants and agrees (on its own behalf and, if applicable, on behalf of each person on whose behalf the Subscriber
is contracting) that:

 

(a)           the Offering, of which this Subscription Agreement forms a part, is not subject to a minimum subscription level and as such, upon
acceptance by the Corporation, subscription funds are immediately available for use by the Corporation;

 

(b)           no
fractional Warrants shall be issued and the Corporation shall round down any fractional number of Warrants to the nearest whole number;

 

(c)           the
Corporation may complete additional financings in the future which may have a dilutive effect on existing shareholders at such time,
including a Subscriber hereunder;

 

(d)           it is aware of the characteristics of the Units, the risks relating to an investment therein and of the fact that it may not be
able to resell the Securities except in accordance with limited exemptions under applicable securities legislation and regulatory policy
until expiry of the applicable restriction period and compliance with the other requirements of applicable law, and it agrees that any
certificates (or DRS) representing the Securities may bear the following legend indicating that the resale of such Securities is restricted:

 

“Unless
permitted under securities legislation, the holder of this security must not trade the security before [that
date that is 4 months and a day after the Closing Date].”

 

(e)           the Closing is subject to the terms of the conditional approval of the Exchange;

 

(f)            the Corporation may pay fees or issue finder warrants or both to one or more finders in accordance with the policies of the Exchange
in connection with the Offering and subject to compliance with applicable securities laws;

 

(g)           the
issuance of the Units shall be subject to any conditions that may be imposed by the Exchange as part of the Exchange’s acceptance
of the Offering, including, without limitation, the conditions noted in paragraphs 4(h) and 4(i);

 

(h)           in the event that the issuance of the Units hereunder may result in, or be part of a transaction that may result in, either or
both

 

(i)               the issuance of listed Shares representing more than 25% of the number of Shares which are outstanding on a non-diluted basis prior
to the Closing; or

 

    Page 6

     

    

 

(ii)              the issuance of listed Shares during any six month period to insiders representing more than
10% of the number of Shares which are outstanding on a non-diluted basis prior to the Closing;

 

the Exchange may require
as a condition of its acceptance of the Offering that the Corporation obtain shareholder approval (excluding, in the case of the 10% Insider
Rule, the votes attached to the Shares held by Insiders and their associates and affiliates); and

 

(i)            in the event that the issuance of the Units may result in, or be part of a transaction that may result in, the creation of a new
 “Insider” or a new “Control Person”, the Exchange may require as a condition of its acceptance of the Offering,
that the Corporation obtain shareholder approval (excluding the votes attached to the Units held by the new Insider or new Control Person
and its associates and affiliates) of the new Insider or new Control Person, as the case may be, prior to the issue of a portion or all
of the Units.

 

5.                             The
Subscriber (on its own behalf and, if applicable, on behalf of each person on whose behalf the Subscriber is contracting) represents,
warrants and covenants to the Corporation that:

 

(a)           it
has been independently advised as to the restrictions with respect to trading in the Securities imposed by applicable securities legislation,
and no representation has been made to it by or on behalf of the Corporation with respect thereto;

 

(b)           it has not received or been provided with, nor has it requested, nor does it have any need to receive, any prospectus or offering
memorandum, or any other document describing the business and affairs of the Corporation which has been prepared for delivery to, and
review by, prospective purchasers in order to assist it in making an investment decision in respect of the Units;

 

(c)           it
has relied solely upon information publicly available on SEDAR (at www.sedar.com) relating to the Corporation and not upon any
oral or written representation as to fact or otherwise made by or on behalf of the Corporation and it does not have knowledge of any
 “material fact” (as defined under applicable securities legislation) about the Corporation that has not been publicly disclosed;

 

(d)           the
Subscriber is resident in the province set out in the “Subscriber’s Address”, which is the ordinary residence or place
of business of the Subscriber and such beneficial purchaser, if applicable, and, if the Subscriber is a corporate entity, it was not
created nor is it used solely for the purpose of acquiring the Units;

 

(e)           the Subscriber is purchasing the Units to be held for investment purposes only and not with a view to immediate resale or distribution
and will not recall or otherwise transfer or dispose of the Units except in accordance with the provisions of applicable securities legislation;

 

(f)            the Subscriber is purchasing the Units as principal for its own account, it is purchasing such Units for investment only and not
for the benefit of any other person and not with a view to the resale or distribution of all or any of the Units and it fully complies
with one or more of the sub-paragraphs set forth below:

 

(i)                the Subscriber

 

(A)              is an “accredited investor” within the meaning of applicable securities laws, including National Instrument 45-106
entitled “Prospectus and Registration Exemptions” (“NI 45-106”); and

 

(B)              has concurrently executed and delivered a Representation Letter in the form attached as Schedule I to this Subscription Agreement,
including Appendix “A” and Appendix “B” thereto; or

 

(ii)              the Subscriber is neither an individual nor a company established solely to acquire the Units and the cost of the Units purchased
by it has an aggregate acquisition of not less than $150,000; or

 

    Page 7

     

    

 

(iii)             __________
(to be initialled by Subscriber, if applicable) - if it is not purchasing under subparagraph 5(f)(i), or (ii), it is purchasing
pursuant to an exemption from prospectus and registration requirements (particulars of which are enclosed herewith or will be provided
on or before the Closing Date) available to it under applicable securities legislation and shall deliver to the Corporation such further
particulars of the exemption(s) and the Subscriber’s qualifications thereunder as the Corporation may request;

 

(g)           if it is not purchasing as principal (and is not otherwise deemed to be purchasing as principal for the purposes of the applicable
prospectus exemption under applicable provincial and territorial securities laws in Canada),

 

(i)               it is duly authorized to enter into this Subscription Agreement and to execute all documentation in connection with the purchase
on behalf of each beneficial purchaser, each of whom is purchasing as principal for its own account, not for the benefit of any other
person, and not with a view to the resale or distribution of all or any of the Securities;

 

(ii)              it
and each beneficial purchaser has provided to the Corporation all of the information required by pages 1 to 3 of this Subscription Agreement
and it acknowledges that the Corporation may be required by law to disclose to certain regulatory authorities the identity of each beneficial
purchaser of Units for whom it may be acting; and

 

(iii)             each
of the principals complies with one or more of subparagraphs 5(f)(i) through (f)(ii), as applicable, and the same is so indicated for
each such principal;

 

(h)           if the Subscriber is a resident of a country other than Canada or the United States (a “Jurisdiction Outside CAN-US”)
then in addition to the other representations and warranties contained herein, the Subscriber represents and warrants that:

 

(i)               the Subscriber is knowledgeable of, or has been independently advised as to, the applicable securities laws of the Jurisdiction
Outside CAN-US which would apply to this Subscription Agreement, if any;

 

(ii)              the Subscriber is purchasing the Subscriber’s Shares pursuant to exemptions from any prospectus, registration or similar
requirements under the applicable securities laws of that Jurisdiction Outside CAN-US or, if such is not applicable, the Subscriber is
permitted to purchase the Subscriber’s Shares under the applicable securities laws of the Jurisdiction Outside CAN-US without the
need to rely on an exemption;

 

(iii)             the
applicable securities laws of the Jurisdiction Outside CAN-US in which the Subscriber resides do not require the Corporation to file
a prospectus, registration statement or similar document or to register the Securities or to make any filings or seek any approvals of
any kind whatsoever from any regulatory authority of any kind whatsoever in the Jurisdiction Outside CAN-US;

 

(iv)             the delivery of this Subscription Agreement, the acceptance of it by the Corporation and the issuance of the Securities to the
Subscriber complies with all applicable laws of the Subscriber’s jurisdiction of residence or domicile and all other applicable
laws and will not cause the Subscriber to become subject to or comply with any disclosure, prospectus or other offering document or reporting
requirements under any such applicable laws; and

 

(v)              the
Subscriber will, if requested by the Corporation, or its counsel deliver to the Corporation a certificate or opinion of local counsel
from the Jurisdiction Outside CAN-US in which the Subscriber resides which will confirm the matters referred to in subsections (ii),
(iii) and (iv) above to the satisfaction of the Corporation and its counsel, acting reasonably

 

(i)            it acknowledges that:

 

(i)               no
securities commission or similar regulatory authority has reviewed or passed on the merits of the Units;

 

    Page 8

     

    

 

(ii)              there
is no government or other insurance covering the Units;

 

(iii)             there are risks associated with the purchase of the Units;

 

(iv)             there
are restrictions on the Subscriber’s ability to resell the Securities and it is the responsibility of the Subscriber to find out
what those restrictions are and to comply with them before selling any of the Securities; and

 

(v)              the Corporation or its agent has advised the Subscriber that the Corporation is relying on an exemption from the requirements to
provide the Subscriber with a prospectus and (except for Subscribers who qualify for a prospectus exemption herein by virtue of being
advised by a registered dealer) to sell the Units through a person or company registered to sell securities under applicable provincial
and territorial securities laws in Canada (including the Securities Act (Ontario) and, as a consequence of acquiring the Units
pursuant to this exemption, certain protections, rights and remedies provided by the Acts, including statutory rights of rescission or
damages, will not be available to the Subscriber;

 

(j)            if
a corporation, partnership, unincorporated association or other entity, it has the legal capacity to enter into and be bound by this
Subscription Agreement and further certifies that all necessary approvals of directors, shareholders, partners or otherwise have been
given and obtained;

 

(k)           if an individual, it is of the full age of majority and is legally competent to execute this Subscription Agreement and take all
action pursuant hereto;

 

(l)            this
Subscription Agreement has been duly and validly authorized, executed and delivered by and constitutes a legal, valid, binding and enforceable
obligation of the Subscriber;

 

(m)          in the case of a subscription by it for Units acting as agent for a disclosed principal, it is duly authorized to execute and deliver
this Subscription Agreement and all other necessary documentation in connection with such subscription on behalf of such principal and
this Subscription Agreement has been duly authorized, executed and delivered by or on behalf of, and constitutes a legal, valid and binding
agreement of, such principal;

 

(n)           it acknowledges that no representation has been made to it:

 

(i)               as
to the future value or price of the Shares;

 

(ii)              that any person will resell or repurchase the Shares; or;

 

(iii)             that any person will refund the purchase price of the Shares;

 

(o)           it has such knowledge in financial and business affairs as to be capable of evaluating the merits and risks of its investment and
it, or where it is not purchasing as principal, each beneficial purchaser, is able to bear the economic risk of loss of its investment;

 

(p)           it
understands that the Units are being offered for sale only on a “private placement” basis and that the sale and delivery
of the Units is conditional upon such sale being exempt from the requirements as to the filing of a prospectus or the preparation of
an offering memorandum in prescribed form or upon the issuance of such orders, consents or approvals as may be required to permit such
sale without the requirement of filing a prospectus or delivering an offering memorandum in prescribed form and that certain protections,
rights and remedies provided by applicable securities legislation, in connection with the filing of a prospectus may not be available
to the Subscriber;

 

(q)           if required by applicable securities legislation, regulations, rules, policies or orders or by any securities commission, stock
exchange or other regulatory authority, the Subscriber will execute, deliver, file and otherwise assist the Corporation in filing, such
reports, undertakings and other documents with respect to the issue of the Units as may be required;

 

    Page 9

     

    

 

 

(r)          
 the entering into of this Subscription Agreement and the transactions contemplated hereby will not result in a violation of any
of the terms or provisions of any law applicable to the Subscriber, or if the Subscriber is not a natural person, any of the Subscriber’s
constating documents, or any agreement to which the Subscriber is a party or by which it is bound;

 

(s)         
the funds representing the Aggregate Subscription Amount which will be advanced by the Subscriber hereunder will not represent
proceeds of crime for the purposes of the Proceeds of Crime (Money Laundering) Act (Canada) and the Subscriber acknowledges that
the Corporation may in the future be required by law to disclose the Subscriber’s name and other information relating to this Subscription
Agreement and the Subscriber’s subscription hereunder, on a confidential basis, pursuant to the Proceeds of Crime (Money Laundering)
Act (Canada) and to the best of the Subscriber’s knowledge (i) none of the subscription funds to be provided by the Subscriber
(A) have been or will be derived from or related to any activity that is deemed criminal under the law of Canada, the United States of
America, or any other jurisdiction, or (B) are being tendered on behalf of a person or entity who has not been identified to the Subscriber,
and (ii) it shall promptly notify the Corporation if the Subscriber discovers that any of such representations ceases to be true, and
to provide the Corporation with appropriate information in connection therewith;

 

(t)          
the Corporation’s counsel, McMillan LLP, is acting solely for the Corporation and in connection with the Offering and the
Subscriber may not rely upon McMillan LLP in any respect. The Subscriber acknowledges that it has been encouraged to and should obtain
independent legal, income tax and investment advice with respect to its subscription for Units and accordingly, has been independently
advised as to the meanings of all terms contained herein relevant to the Subscriber for the purposes of giving representations, warranties
and covenants under this Subscription Agreement;

 

(u)         
the information provided by the Subscriber on pages 1, 2 and 3 of this Subscription Agreement and under the heading “Information
Regarding The Subscriber” is true and correct in all material respects and will be true and correct as of the Closing Date;

 

(v)         
it does not act jointly or in concert with any other Subscriber under the Offering for the purposes of the acquisition of the Units;

 

(w)        
it will not resell the Securities or any of them, except in accordance with the provisions of applicable securities legislation
and stock exchange rules, if applicable, in the future;

 

(x)         
the delivery of this subscription, the acceptance hereof by the Corporation and the issuance of the Units to the Subscriber complies
with all applicable laws of the Subscriber’s jurisdiction of residence and domicile and will not cause the Corporation or any of
its officers or directors to become subject to or require any disclosure, prospectus or other reporting requirement;

 

(y)         
the Corporation may complete additional financings in the future in order to develop the business of the Corporation and to fund
its ongoing development; there is no assurance that such financings will be available and, if available, on reasonable terms; any such
future financings may have a dilutive effect on current securityholders, including the Subscriber; and if such future financings are not
available, the Corporation may be unable to fund its ongoing development and the lack of capital resources may result in the failure of
its business venture; and

 

(z)          
the Subscriber is capable of assessing the proposed investment as a result of the Subscriber’s financial experience or as
a result of advice received from a registered person other than the Corporation or any affiliates thereof.

 

Closing

 

6.                            The
Subscriber agrees to deliver to the Corporation, not later than the Closing Time: (a) this duly completed and executed Subscription
Agreement, including all applicable Schedules hereto and Appendices thereto; and (b) the Aggregate Subscription Amount subscribed
for under this Subscription Agreement in accordance with the Instructions on the Cover Page or payment of the same amount in such
other manner as is acceptable to the Corporation. If payment is made in a currency other than Canadian dollars, the Subscriber
acknowledges and agrees that it shall be responsible to make up for any deficiency in the payment of the Aggregate Subscription
Price as a result of the exchange of such funds into Canadian dollars.

 

    Page 10

     

    

 

7.                           
The sale of the Units pursuant to this Subscription Agreement will be completed at the offices of McMillan LLP, the Corporation’s
counsel, in Vancouver, British Columbia at 10:00 a.m. (Vancouver time) or such other time as the Corporation may determine (the “Closing
Time”) on such date (the “Closing Date”) the Corporation may determine within 45 days of its acceptance of
this Subscription Agreement. The Corporation may complete the Offering in one or more Closings. At the Closing Time, the Corporation will
deliver, or cause to be delivered, according to the instructions set out under Delivery Instructions herein the certificates (or DRS)
representing the Units as registered in the name of the Subscriber or its nominee as set out under Registration Instructions provided
that the Subscriber shall have delivered to the Corporation the completed Subscription Agreement and the Aggregate Subscription Amount.

 

8.                           
The obligations of the parties hereunder are subject to acceptance of the terms of the Offering by the Exchange.

 

9.                          
The Corporation shall be entitled to rely on delivery of a copy of executed subscriptions by electronic means, and acceptance by
the Corporation of such electronic subscriptions (including, without limitation by facsimile or email delivery) shall be legally effective
to create a valid and binding agreement between the Subscriber and the Corporation in accordance with the terms hereof. Prior to Closing,
any funds advanced to the Corporation on account of the Aggregate Subscription Amount shall constitute a non-interest bearing loan to
the Corporation, which loan shall be due and payable to the Subscriber on the request of the Subscriber in the event that the Closing
does not occur within 90 days of its acceptance of this Subscription Agreement.

 

Privacy Legislation

 

(a)                         
The Subscriber acknowledges and consents to the fact that the Corporation is collecting the Subscriber’s (and any Disclosed
Principal for whom the Subscriber is acting hereunder) personal information (as that term is defined under applicable privacy legislation,
including, without limitation, the Personal Information Protection and Electronic Documents Act (Canada) and any other applicable
similar replacement or supplemental provincial or federal legislation or laws in effect from time to time) for the purpose of completing
the Subscriber’s subscription. The Subscriber acknowledges and consents to the Corporation retaining the personal information for
so long as permitted or required by applicable law or business practices. The Subscriber further acknowledges and consents to the fact
that the Corporation may be required by applicable securities legislation, stock exchange rules and/or Investment Industry Regulatory
Organization of Canada rules to provide regulatory authorities with any personal information provided by the Subscriber respecting itself
(and any Disclosed Principal for whom the Subscriber is acting hereunder). The Subscriber represents and warrants that it has the authority
to provide the consents and acknowledgements set out in this paragraph on behalf of all Disclosed Principals for whom the Subscriber is
acting. In addition to the foregoing, the Subscriber agrees and acknowledges that the Corporation may use and disclose the Subscriber’s
personal information, or that of each Disclosed Principal for whom the Subscriber is acting hereunder, as follows:

 

(i)           
for internal use with respect to managing the relationships between and contractual obligations of the Corporation and the Subscriber
or any Disclosed Principal for whom the Subscriber is acting hereunder;

 

(ii)          
for use and disclosure to the Corporation’s transfer agent and registrar;

 

(iii)        
for use and disclosure for income tax related purposes, including without limitation, where required by law, disclosure to Canada
Revenue Agency;

 

(iv)        
disclosure to securities regulatory authorities (including the TSX) and other regulatory bodies with jurisdiction with respect
to reports of trade and similar regulatory filings;

 

(v)         
disclosure to a governmental or other authority (including the TSX) to which the disclosure is required by court order or subpoena
compelling such disclosure and where there is no reasonable alternative to such disclosure;

 

(vi)        
disclosure to professional advisers of the Corporation in connection with the performance of their professional services;

 

    Page 11

     

    

 

(vii)      
 disclosure to any person where such disclosure is necessary for legitimate business reasons and is made with the Subscriber’s
prior written consent;

 

(viii)      
disclosure to a court determining the rights of the parties under this Subscription Agreement; or

 

(ix)         
for use and disclosure as otherwise required or permitted by law.

 

The Subscriber further acknowledges
and agrees that the TSX collects personal information in forms submitted by the Corporation, which will include personal information
regarding the Subscriber. The Subscriber agrees that the TSX may use this information in the manner provided for in Appendix 6A to the
TSX Company Manual, a copy of which may be viewed at the TSX website, www.tsx.com and is incorporated herein by reference. The
Subscriber further acknowledges that the securities regulatory authorities, including, without limitation, the British Columbia Securities
Commission, the Alberta Securities Commission and the Ontario Securities Commission, collect personal information in forms submitted
to it by the Corporation, including information about the Subscriber, the Subscriber’s address and contact information, and the
Subscriber’s subscription. The Subscriber acknowledges that any such securities commission is entitled to collect the information
under authority granted to each respective regulatory authority under applicable securities legislation for the purpose of administration
and enforcement of the applicable securities legislation. The Subscriber acknowledges that it may obtain information regarding the collection
of this information by contacting, in the case of the British Columbia Securities Commission, British Columbia Securities Commission,
P.O. Box 10142, Pacific Centre, 701 West Georgia Street, Vancouver, British Columbia, V7Y 1L2, Telephone: (604) 899-6500 or (800) 373-6393,
Facsimile: (604) 899-6581, in the case of the Alberta Securities Commission, Alberta Securities Commission, Suite 600, 250 –
5th St. SW, Calgary, Alberta, T2P 0R4, Telephone: (403) 355-4151, Facsimile: (403) 297-6156, and, in the case of the Ontario
Securities Commission, the Administrative Assistant to the Director of Corporate Finance, Ontario Securities Commission, Suite 1903,
Box 5520, Queen Street West, Toronto, Ontario M5H 3S8, Telephone: (416) 593-3682, Facsimile: (416) 593-8252. The Subscriber
consents to the collection of personal information by the applicable securities regulatory authorities, including, without limitation,
the British Columbia Securities Commission, the Alberta Securities Commission and the Ontario Securities Commission.

 

General

 

10.                        
The Subscriber agrees that the representations, warranties and covenants of the Subscriber herein will be true and correct both
as of the execution of this Subscription Agreement and as of the Closing Time and will survive the issuance of the Units. The representations,
warranties and covenants of the Subscriber herein are made with the intent that they be relied upon by the Corporation in determining
the eligibility of a purchaser of Units and the Subscriber agrees to indemnify the Corporation against all losses, claims, costs, expenses
and damages or liabilities which it may suffer or incur which are caused or arise from an inaccuracy or breach thereof and reliance thereon.
The Subscriber undertakes to immediately notify the Corporation by written notice to ProMIS Neurosciences Inc. sent to its office at 1920
Yonge Street, Suite 200, Toronto, ON M4S 3E2 or by email to [***] of any change in any statement
or other information relating to the Subscriber set forth herein which takes place prior to the Closing Time.

 

11.                        
The Subscriber acknowledges and agrees that all costs incurred by the Subscriber (including any fees and disbursements of any counsel
retained by the Subscriber) relating to the sale of the Units to the Subscriber shall be borne by the Subscriber.

 

12.                         
The Subscriber acknowledges that upon a subscription being accepted by the Corporation, the Corporation will, subject to the terms
and conditions set out herein, issue to the Subscriber certificates (or DRS) evidencing the Subscriber’s ownership of the Units.

 

13.                         
The terms and provisions of this Subscription Agreement shall be binding upon and enure to the benefit of the Subscriber and the
Corporation and their respective heirs, executors, administrators, successors and permitted assigns

 

14.                         
The contract arising out of this Subscription Agreement and all documents relating thereto shall be governed by and construed in
accordance with the laws of the Province of British Columbia and the federal laws of Canada applicable therein. The parties irrevocably
attorn to the exclusive jurisdiction of the courts of the Province of British Columbia.

 

    Page 12

     

    

 

15.                         
 Time is of the essence of this Subscription Agreement.

 

16.                         
Neither party to this Subscription Agreement may assign all or part of its interest in or to this Subscription Agreement without
the consent in writing of the other party hereto, except for the assignment by a Subscriber who is acting as nominee or agent to the beneficial
owner and as otherwise herein provided.

 

17.                        
This Subscription Agreement represents the entire agreement of the parties hereto relating to the subject matter hereof and there
are no representations, covenants or other agreements relating to the subject matter hereof except as stated or referred to herein. Neither
this Subscription Agreement nor any provision hereof shall be modified, changed, discharged or terminated except by an instrument in writing
signed by the party against whom any waiver, change, discharge or termination is sought.

 

18.                         
The covenants, representations and warranties contained herein shall survive the closing of the transactions contemplated hereby.

 

19.                         
In this Subscription Agreement (including attachments), references to “$” or “Cdn. $” are to Canadian dollars.

 

20.                        
The parties hereto acknowledge and confirm that they have requested that this Subscription Agreement as well as all notices and
other documents contemplated hereby be drawn up in the English language. Les parties aux présentes reconnaissent et confirment
qu’elles ont convenu que la présente convention de souscription ainsi que tous les avis et documents qui s’y rattachent
soient rédigés dans la langue anglaise.

 

    Page 13

     

    

 

SCHEDULE I

REPRESENTATION LETTER

(FOR CANADIAN ACCREDITED INVESTORS)

 

		TO:	ProMIS Neurosciences Inc. (the “Corporation”)

 

In connection with the purchase of units of the
Corporation (“Units”) by the undersigned subscriber or, if applicable, the principal on whose behalf the undersigned
is purchasing as agent (the “Subscriber” for the purposes of this Schedule I), the Subscriber hereby represents, warrants,
covenants and certifies to the Corporation that:

 

		1.	The Subscriber is purchasing the Units as principal for its own account or is deemed to be acting as principal
pursuant to applicable securities laws, including National Instrument 45-106 entitled “Prospectus and Registration Exemptions”
(“NI 45-106”);

 

		2.	The Subscriber is an “accredited investor” within the meaning of applicable securities
laws, including NI 45-106, by virtue of satisfying one or more of the categories set out in Appendix “A” to this Representation
Letter;

 

		3.	If the Subscriber is an individual, he or she has completed the attached Form 45-106F9 -- Form for
Individual Accredited Investors set out in Appendix “B” to this Representation Letter unless the individual qualifies
under a category set out in Appendix “A” other than (j), (k) or (l) of the definition of “accredited investor”;
and

 

		4.	Upon execution of this Schedule I by the Subscriber, this Schedule I shall be incorporated into and form
a part of the Subscription Agreement.

 

Dated: _______________________, 2018.

 

	 	Print name of Subscriber
	 	 
	 	By:	 
	 	 	Signature
	 	 	 
	 	 	Print name of Signatory (if different from Subscriber)
	 	 	 
	 	 	Title

 

IMPORTANT: PLEASE INITIAL APPENDIX “A”
OVER PAGE

 

    Page 1

     

    

 

APPENDIX “A”

TO SCHEDULE 1

 

NOTE: THE SUBSCRIBER MUST INITIAL BESIDE THE APPLICABLE PORTION
OF THE DEFINITION BELOW AND COMPLETE EACH QUESTION WHICH FOLLOWS THE APPLICABLE PORTION OF THE DEFINITION.

 

Accredited Investor – (as defined in National Instrument
45-106, and in Ontario, as defined in Section 73.3 of the Securities Act (Ontario) as supplemented by the definition in National
Instrument 45-106) includes:

 

	_______	(a)	except in Ontario, a Canadian financial institution, or a Schedule III bank,
	_______	(a.1)	in Ontario, a financial institution described in paragraph 1, 2 or 3 of subsection 73.1 (1) of the Securities Act (Ontario),
	_______	(b)	except in Ontario, the Business Development Bank of Canada incorporated under the Business Development Bank of Canada Act (Canada),
	_______	(b.1)	in Ontario, the Business Development Bank of Canada,
	_______	(c)	except in Ontario, a subsidiary of any person referred to in paragraphs (a) or (b), if the person owns all of the voting securities of
the subsidiary, except the voting securities required by law to be owned by directors of that subsidiary,
	_______	(c.1)	in Ontario, a subsidiary of any person or Corporation referred to in clause (a.1) or (b.1), if the person or Corporation owns all of
the voting securities of the subsidiary, except the voting securities required by law to be owned by directors of that subsidiary,
	_______	(d)	except in Ontario, a person registered under the securities legislation of a jurisdiction of Canada as an adviser or dealer,
	_______	(d.1)	in Ontario, a person or Corporation registered under the securities legislation of a province or territory of Canada as an adviser or
dealer, except as otherwise prescribed by the regulations,
	_______	(e)	an individual registered under the securities legislation of a jurisdiction of Canada as a representative of a person referred to in
paragraph (d),
	_______	(e.1)	an individual formerly registered under the securities legislation of a jurisdiction of Canada, other than an individual formerly registered
solely as a representative of a limited market dealer under one or both of the Securities Act (Ontario) or the Securities Act
(Newfoundland and Labrador),
	_______	(f)	except in Ontario, the Government of Canada or a jurisdiction of Canada, or any crown corporation, agency or wholly owned entity of the
Government of Canada or a jurisdiction of Canada,
	_______	(f.1)	in Ontario, the Government of Canada, the government of a province or territory of Canada, or any Crown corporation, agency or wholly
owned entity of the Government of Canada or of the government of a province or territory of Canada,
	_______	(g)	a municipality, public board or commission in Canada and a metropolitan community, school board, the Comité de gestion de la taxe
scolaire de l’île de Montréal or an intermunicipal management board in Québec,

 

     
 

     

    

 

	_______	(h)	any national, federal, state, provincial, territorial or municipal government of or in any foreign jurisdiction, or any agency of that
government,
	_______	(i)	except in Ontario, a pension fund that is regulated by the Office of the Superintendent of Financial Institutions (Canada), a pension
commission or similar regulatory authority of a jurisdiction of Canada,
	_______	(i.1)	 in Ontario, a pension fund that is regulated by either the Office of the Superintendent of Financial Institutions (Canada) or a pension
commission or similar regulatory authority of a province or territory of Canada,
	_______	
    (j) 
	an
    individual who, either alone or with a spouse, beneficially owns financial assets having an aggregate realizable value that before taxes,
    but net of any related liabilities, exceeds $1,000,000,

     

    [If this
is your applicable category, you must also complete Form 45-106F9 attached as Appendix B]

	_______	(j.1)	an individual who beneficially owns financial assets having an aggregate realizable value that, before taxes but net of any related
liabilities, exceeds $5,000,000,
	_______	
    (k)
	an
    individual whose net income before taxes exceeded $200,000 in each of the 2 most recent calendar years or whose net income before taxes
    combined with that of a spouse exceeded $300 000 in each of the 2 most recent calendar years and who, in either case, reasonably expects
    to exceed that net income level in the current calendar year,

     

    [If this is your
    applicable category, you must also complete Form 45-106F9 attached as Appendix B]

     

	_______	
    (l)
	an individual
    who, either alone or with a spouse, has net assets of at least $5,000,000,

     

    [If this is your
    applicable category, you must also complete Form 45-106F9 attached as Appendix B]

     

	_______	(m)	a person, other than an individual or investment fund, that has net assets of at least $5,000,000 as shown on its most recently prepared
financial statements,
	_______	
    (n)
	an
investment fund that distributes or has distributed its securities only to:

	 	 	(i)	a person that is or was an accredited investor at the time of the distribution,
	 	 	(ii)	a person that acquires or acquired securities in the circumstances referred to in sections 2.10 [Minimum amount investment], or 2.19 [Additional
investment in investment funds], or
	 	 	(iii)	a person described in paragraph (i) or (ii) that acquires or acquired securities under section 2.18 [Investment fund reinvestment],
	_______	(o)	an investment fund that distributes or has distributed securities under a prospectus in a jurisdiction of Canada for which the regulator
or, in Québec, the securities regulatory authority, has issued a receipt,
	_______	(p)	a trust Corporation or trust corporation registered or authorized to carry on business under the Trust and Loan Companies Act (Canada) or under comparable legislation in a jurisdiction of Canada or a foreign jurisdiction, acting on behalf of a fully managed account managed by the trust Corporation or trust corporation, as the case may be,

 

     
 

     

    

 

	_______	(q)	a person acting on behalf of a fully managed account managed by that person, if that person is registered or authorized to carry on business
as an adviser or the equivalent under the securities legislation of a jurisdiction of Canada or a foreign jurisdiction,
	_______	(r)	a registered charity under the Income Tax Act (Canada) that, in regard to the trade, has obtained advice from an eligibility adviser
or an adviser registered under the securities legislation of the jurisdiction of the registered charity to give advice on the securities
being traded,
	_______	(s)	an entity organized in a foreign jurisdiction that is analogous to any of the entities referred to in paragraphs (a) to (d) paragraph
(i) [and in Ontario, paragraphs (a.1) to (d.1) or paragraph (i.1)] in form and function,
	_______	(t)	a person in respect of which all of the owners of interests, direct, indirect or beneficial, except the voting securities required by
law to be owned by directors, are persons that are accredited investors
	_______	(u)	an investment fund that is advised by a person registered as an adviser or a person that is exempt from registration as an adviser,
	_______	(v)	a person that is recognized or designated by the securities regulatory authority or, except in Ontario and Québec, the regulator
as an accredited investor,
	_______	(v.1)	in Ontario, a person or Corporation that is recognized or designated by the Commission as an accredited investor,
	_______	(w)	a trust established by an accredited investor for the benefit of the accredited investor’s family members of which a majority of
the trustees are accredited investors and all of the beneficiaries are the accredited investor’s spouse, a former spouse of the
accredited investor or a parent, grandparent, brother, sister, child or grandchild of that accredited investor, of that accredited investor’s
spouse or of that accredited investor’s former spouse.

 

Dated: __________________, 201__.

 
	Print name of Subscriber	 

 
	Signature	 

 
	Print name of Signatory (if different from Subscriber)	 

 
	Title	 

 

     
 

     

    

 

For the purposes hereof:

 

			“control person” has the meaning ascribed
to that term in securities legislation except in Manitoba, Ontario, Quebec, Nova Scotia, Newfoundland and Labrador, Prince Edward Island,
the Northwest Territories and Nunavut where “control person” means any person that holds or is one of a combination of persons
that hold:

 

		(i)	a sufficient number of any of the securities of an issuer so
as to affect materially the control of the issuer; or
		(ii)	more than 20% of the outstanding voting securities of an issuer
except where there is evidence showing that the holding of those securities does not affect materially the control of that issuer;

 

			“eligibility adviser” means:

 

		(i)	a person that is registered as an investment dealer or in an
equivalent category of registration under the securities legislation of the jurisdiction of a Subscriber and authorized to give advice
with respect to the type of security being distributed; and
		(ii)	in Saskatchewan or Manitoba, also means a lawyer who is a practicing
member in good standing with a law society of a jurisdiction of Canada or a public accountant who is a member in good standing of an
institute or association of chartered accountants, certified general accountants or certified management accountants in a jurisdiction
of Canada provided that the lawyer or public accountant must not:

		(A)	have a professional, business or personal relationship with
the issuer, or any of its directors, executive officers, founders or control persons; and

		(B)	have acted for or been retained personally or otherwise as an
employee, executive officer, director, associate or partner of a person that has acted for or been retained by the issuer or any of its
directors, executive officers, founders or control persons within the previous 12 months;

 

			“financial assets” means (i) cash, (ii) securities
or (iii) a contract of insurance, a deposit or an evidence of a deposit that is not a security for the purposes of securities legislation.
These financial assets are generally liquid or relatively easy to liquidate. The value of a purchaser’s personal residence would
not be included in a calculation of financial assets;

 

			“financial statements” for the purposes of
paragraph (m) of the “accredited investor” definition must be prepared in accordance with generally accepted accounting principles;

 

			“founder” means, in respect of an issuer,
a person who:

		(i)	acting alone, in conjunction or in concert with one or more
persons, directly or indirectly, takes the initiative in founding, organizing or substantially reorganizing the business of the issuer;
and

		(ii)	at the time of the trade is actively involved in the business
of the issuer;

 

			“fully managed account” means an account
of a client for which a person makes the investment decisions if that person has full discretion to trade in securities for the account
without requiring the client’s express consent to a transaction;

 

			“investment fund” has the meaning ascribed
thereto in National Instrument 81-106 - Investment Fund Continuous Disclosure;

 

			“net assets” means all of the purchaser’s
total assets minus all of the purchaser’s total liabilities. Accordingly, for the purposes of the net asset test, the calculation
of total assets would include the value of a purchaser’s personal residence and the calculation of total liabilities would include
the amount of any liability (such as a mortgage) in respect of the purchaser’s personal residence. To calculate a purchaser’s
net assets under the “accredited investor” definition, subtract the purchaser’s total liabilities from the purchaser’s
total assets (including real estate). The value attributed to assets should reasonably reflect their estimated fair value. Income tax
should be considered a liability if the obligation to pay it is outstanding at the time of the distribution of the security;

 

     
 

     

    

 

		“related liabilities” means:

		(i)	liabilities incurred or assumed for the purpose of financing
the acquisition or ownership of financial assets; or

		(ii)	liabilities that are secured by financial assets;

 

		“spouse” means an individual who:

		(i)	is married to another individual and is not living separate
and apart within the meaning of the Divorce Act (Canada), from the other individual;

		(ii)	is living with another individual in a marriage-like relationship,
including a marriage-like relationship between individuals of the same gender; or

		(iii)	in Alberta, is an individual referred to in paragraph (i) or
(ii) immediately above or is an adult interdependent partner within the meaning of the Adult Interdependent Relationships Act (Alberta);
and

 

     
 

     

    

 

APPENDIX “B”

TO SCHEDULE 1

 

Form 45-106F9 - Form for Individual Accredited
Investors

 

	
     

    WARNING!

     

    This investment is risky. Don’t invest
    unless you can afford to lose all the money you pay for this investment.

 

	SECTION 1 TO BE COMPLETED BY ISSUER OR SELLING SECURITY HOLDER
	1.       About your investment
	Type of securities:   Common Shares and Warrants	Issuer:  ProMIS Neurosciences Inc.
	SECTIONS 2 TO 4 TO BE COMPLETED BY THE PURCHASER
	2.       Risk acknowledgement
	This investment is risky. Initial that you understand that:	Your initials
	Risk of loss – You could lose your entire investment of $________. 	 
	Liquidity risk – You may not be able to sell your investment quickly – or at all.	 
	Lack of information – You may receive little or no information about your investment.	 
	Lack
    of advice – You may not receive advice from the salesperson about whether this investment is suitable for you unless the
    salesperson is registered. The salesperson is the person who meets with, or provides information to, you about making this investments.
    To check whether the salesperson is registered, go to www.aretheyregistered.ca.	 
	3.       Accredited investor status
	You must meet at least one of the following criteria to be able to make this investment. Initial the statement that applies to you. (You may initial more than one statement.) The person identified in section 6 is responsible for ensuring that you meet the definition of accredited investor. That person, or the salesperson identified in section 5, can help you if you have questions about whether you meet these criteria.	Your initials
	·    Your net income before taxes was more than $200,000 in each for the 2 most recent calendar years, and you expect it to be more than $200,000 in the current calendar year. (You can find your net income before taxes on your personal income tax return.)	 
	·    Your net income before taxes combined with your spouse’s was more than $300,000 in each of the 2 most recent calendar years, and you expect your combined net income before taxes to be more than $300,000 in the current calendar year.	 
	 	 	 

 

     
 

     

    

 

	·    Either alone or with your spouse, you own more than $1 million in cash and securities, after subtracting any debt related to the case and securities.	 
	·     Either alone or with your spouse, you may have net assets worth more than $5 million. (Your net assets are your total assets (including real estate) minus your total debt.)	 
	4.       Your name and signature
	By signing this form, you confirm that you have read this form and you understand the risks of making this investment as identified in this form.
	First and last name (please print):
	Signature:	Date: 
	SECTION 5 TO BE COMPLETED BY SALESPERSON
	5.       Salesperson information
	[Instruction: The salesperson is the person who meets with, or provides information to, the purchaser with respect to making this investment. That could include a representative of the issuer or selling security holder, a registrant or a person who is exempt from the registration requirement.]
	First and last name of salesperson (please print):
	Telephone:	Email:
	Name of firm (if registered):
	SECTION 6 TO BE COMPLETED BY THE ISSUER OR SELLING SECURITY HOLDER
	6.       For more information about this investment
	ProMIS Neurosciences Inc.
 Kristi Lanier, Finance Director
 Tel: [***]
 E-mail: [***]
 Website: www.promisneurosciences.com
 For more information about prospectus exemptions, contact your local securities regulator. You can find contact information at

                                                                                www.
                                            securities-administrators.caExhibit 10.22 

 

Certain identified information has been excluded
from the exhibit pursuant to Item 601(a)(6) of Regulation S-K due to personal privacy concerns. Redacted information is indicated by:
[***] 

 

PROMIS NEUROSCIENCES INC.

SUBSCRIPTION AGREEMENT

FOR

NON-U.S. PERSONS

 

	
    HAVE YOU COMPLETED THIS SUBSCRIPTION AGREEMENT PROPERLY?

     

    The following items in this Subscription Agreement must be completed.
    (Please initial each box.) 

    

	 
	 	 	  Provide information and answers in the boxes on pages 1, 2 and 3.
	 
	 	 	  Sign the execution page on page 1 of this Subscription Agreement. 
	 
	 	 	  Complete Schedule “1” Accredited Investor Representation Letter and sign
	 
	 	 	 

Delivery of Subscription forms may be made
by

 

email to: [***]

 

facsimile to: fax #: [***]

 

Delivery of
certified cheque, money order or bank draft may be made by courier/mail to:

 

ProMIS Neurosciences Inc. Attention: CFO

1920 Yonge Street, Suite 200, Toronto, ON M4S 3E2

 

Alternatively, delivery of funds may also be made via electronic
wire transfer in accordance with the wire transfer instructions set forth below:

 

To wire Canadian $ funds:

 

Beneficiary Bank: [***]

Bank Address: [***]

Account # [***]

Bank #:[***]

SWIFT Code: [***]

Currency: [***]

Beneficiary: PROMIS NEUROSCIENCES INC.

Beneficiary address: 1920 Yonge Street, Suite 200, Toronto, ON M4S
3E2

 

If you wish to wire funds in currency other than CDN$, please
contact the Corporation by email: [***]

_______________________________________________________________________________

 

     

     

    

 

SUBSCRIPTION FOR UNITS

 

		TO:	ProMIS Neurosciences Inc. (the “Corporation”)

The undersigned (the “Subscriber”, including, if applicable, each Disclosed Principal (as hereinafter defined) for
whom the undersigned is acting hereunder) hereby irrevocably subscribes for and agrees to purchase the number of units of the Corporation
(the “Units”) set forth below for the aggregate subscription amount set forth below (the “Aggregate Subscription
Amount”), representing a subscription price of CDN$0.23 or US$0.173 per Unit, on the terms and conditions set
forth in “Terms and Conditions of Subscription for Units of ProMIS Neurosciences Inc..” attached hereto (together with the
face pages and the attached Schedules, the “Subscription Agreement”). Each Unit consists of one common share of the
Corporation (a “Common Share”) and one transferable share purchase warrant (a “Warrant”).

 

Each whole Warrant entitles the holder to purchase
one Common Share (a “Warrant Share”) at any time for a five year period, subject to acceleration (as noted below),
at a price of CDN$0.48 per Warrant Share. At any time after the expiry of the four-month hold period applicable to the Warrants,
the Corporation may accelerate the expiry of the Warrants if if either one of the conditions (a “Trigger Condition”)
below is met:

 

		(i)	the twenty-day volume-weighted average trading price (“20 day VWAP”) of the Common
Shares on the TSX, and/or such other exchange on which the Common Shares may be listed, is greater than CDN$1.00, or

 

		(ii)	the Corporation enters into a partnering deal within eighteen months of the Closing of this Subscription
that results in minimum proceeds to the Corporation of US$5M and the 20 day VWAP is greater than CDN$0.48 at any time following the announcement
of such a partnering deal,

 

provided that, in either case, (i) the
Corporation disseminates a press release announcing the occurrence of the applicable Trigger Condition, and (ii) the accelerated expiry
date is not less than 30 calendar days after such news release is disseminated.

 

For greater certainty, the 20 day VWAP of the
Common Shares shall be calculated by dividing the total value by the total volume of Common Shares traded (on all exchanges, including
the TSX and such other exchange on which the Common Shares may be listed) for the twenty trading days immediately preceding the applicable
date.

 

The Units, the Common Shares, the Warrants and
the Warrant Shares are hereinafter referred to together as the “Securities”.

 

	
    

     

    Number of Units: ___________________________________

     
	
    

     

    Aggregate Subscription Amount: CDN$ __________

     

	Name and Signature of Subscriber
	Individual Subscriber 	 	Non-Individual Subscriber (e.g., Corporation)
	 	 	 
	(Print Name of Individual Subscriber) 	 	(Print Name of Non-Individual Subscriber) 
	 	 	 
	(Signature of Individual Subscriber) 	 	(Signature of Authorized Signatory) 
	 	 	 
	 	 	(Print Name and Official Capacity or Title of Signatory) 

The signatory represents that he has authority to bind the Subscriber. 
	 	 	 	 

    Page 1 

     

    

 

	
    ONLY IF the Subscriber is signing as agent or trustee
    for a principal (a “Disclosed Principal”) and is not purchasing as trustee or agent for accounts fully managed by it, so as
    to be deemed to be purchasing as principal pursuant to National Instrument 45-106, complete the following and, if applicable, ensure that
    all Schedules are completed on behalf of such Disclosed Principal:

     

    _____________________________________________________________________________________________

    (Name of Disclosed Principal and, if Disclosed Principal is not an individual, of the contact person of Disclosed Principal)

    

    

     

    _____________________________________________________________________________________________

    (Address and Telephone Number of Disclosed Principal or, if Disclosed Principal is not an individual, of the contact person of Disclosed
    Principal)

     

 

	Address of Subscriber - Residential for Individual / Business for Non-Individual Subscriber
	 	 	 
	Address of Subscriber 	 	(Telephone Number) 
	 	 	 
	City, Province, Postal Code 	 	(Facsimile Number) 
	 	 	 
	 	 	(Email address) 

 

 

	
    REGISTRATION INSTRUCTIONS

     
	 	DELIVERY INSTRUCTIONS
	
    Register the Common Shares and Warrants as set forth below
    (only complete if different from above):

     

    ______________________________________________________

    

    (Name)

     

    ______________________________________________________

    (Account reference, if applicable)

     

    ______________________________________________________

    

    (Address)

     

    ______________________________________________________

     

    

     
	 	
    Deliver the Common Shares and Warrants as set forth below:

     

     

    __________________________________________________________

    (Name)

     

    __________________________________________________________

    

    (Account reference, if applicable)

     

    __________________________________________________________

    (Contact Name)

     

    __________________________________________________________

    (Address)

     

    __________________________________________________________

     

    

 

INFORMATION REGARDING THE SUBSCRIBER

 

Please check the appropriate box (and complete
the required information, if applicable) in each section:

 

		1.	Security Holdings. Prior to giving effect to the issuance of the securities being subscribed for
under this Subscription Agreement, the Subscriber and all persons acting jointly and in concert with the Subscriber currently own, directly
or indirectly, or exercise control or direction over (provide additional detail as applicable):

 

	 	 ̈	 _________________ common shares of the Corporation and the following other kinds of rights and convertible securities (including but
not limited to convertible debt, warrants and options) entitling the Subscriber to acquire additional common shares of the Corporation:

 

    Page 2 

     

    

 

	 	 	 

 

	 	 	 

 

	 	 ̈	 No shares of the Corporation or rights or securities convertible into shares of the Corporation.

 

		2.	Insider Status. The Subscriber either:

 

	 	 ̈	Is an “Insider” of the Corporation as defined in the Policies of the Exchange (as hereinafter defined) by virtue of being:

 

		(a)	a director or executive officer of the Corporation;

		(b)	a director or executive officer of a company that is an Insider or subsidiary of the Corporation;

		(c)	a person that beneficially owns or controls, directly or indirectly, voting shares of the Corporation
carrying more than 10% of the voting rights attached to all the Corporation’s outstanding voting shares; or

		(d)	the Corporation itself if it holds any of its own securities.

 

	 	 ̈	 Is not an Insider of the Corporation.

 

		3.	Pro Group Status. The Subscriber either:

 

	 	 ̈	Is a Member of the “Pro Group”, which is defined in the Rules of the Exchange as either individually or as a group:

 

		1.	the member (i.e. a member of the Exchange under the Exchange requirements);

		2.	employees of the member;

		3.	partners, officers and directors of the member;

		4.	affiliates of the member;

		5.	such other persons as the Exchange may determine; and

		6.	associates of any parties referred to in paragraphs 1 through 5 above.

 

	 	 ̈	 Is not a member of the Pro Group.

 

		4.	Registrant Status. The Subscriber either:

 

	 	 ̈	Is a “Registrant” as defined in the Securities Act (British Columbia) by virtue of being a person registered or required
to be registered under the Securities Act (British Columbia.

 

	 	 ̈	Is not a Registrant.

 

    Page 3 

     

    

 

ACCEPTANCE:          The Corporation hereby accepts the subscription as set forth above on the terms and conditions contained in this Subscription Agreement.

 

______________________, 2018.

 

PROMIS NEUROSCIENCES INC.

 

	By: 	 	 

 

    Page 4 

     

    

 

TERMS AND CONDITIONS OF SUBSCRIPTION FOR

UNITS OF PROMIS NEUROSCIENCES INC.

 

Terms of the Offering

 

1.                             The Subscriber acknowledges (on its own behalf and, if applicable, on behalf of each person on whose behalf the Subscriber is contracting)
that this subscription is subject to acceptance or rejection by the Corporation, in its sole and absolute discretion, in whole or in part.
The parties agree that this Subscription and all money tendered herewith will be returned to the Subscriber, without interest or deduction,
if this Subscription is not accepted by the Corporation.

 

2.                             The Subscriber acknowledges (on its own behalf and, if applicable, on behalf of each person on whose behalf the Subscriber is contracting)
that:

 

(a)           the Corporation is offering (the “Offering”) the Units on a private placement basis under the terms of this
Subscription Agreement;

 

(b)           notwithstanding section 2(a) above, this Offering will not in any way restrict the Corporation from issuing additional securities
of the Corporation at prices, on terms and in amounts as may be determined by the Corporation, in its sole and absolute discretion, including
an amendment to the Offering to increase the size of the Offering; and

 

(c)           the issuance of the Units shall be subject to any conditions that may be imposed by the Exchange as part of the Exchange’s
acceptance of the Offering, including, without limitation, in the event that the issuance of the Units hereunder may result in, or be
part of a transaction that may result in:

 

(i)             the issuance of listed Shares representing more than 25% of the number of Shares which are outstanding on a non-diluted basis prior
to the Closing (the “25% Dilution Rule”);

 

(ii)            the issuance of listed Shares during any six month period to insiders representing more than 10% of the number of Shares which
are outstanding on a non-diluted basis prior to the Closing (the “10% Insider Rule”); or

 

(iii)           the issuance of listed Shares that will materially affect control of the Corporation.

 

Representations and Warranties of the Corporation

 

3.                              The Corporation hereby represents and warrants to the Subscriber (and acknowledges that the Subscriber is relying thereon) that:

 

(a)                
The Corporation is a duly amalgamated and validly subsisting corporation under the laws of Canada and has full corporate power
and authority to perform each of its obligations as herein contemplated.

 

(b)               
The Corporation is listed on the TSX (the “Exchange”) and as a result is subject to the rules and policies of
the Exchange.

 

(c)                
The Corporation is a “reporting issuer” in good standing under the securities laws of the provinces of Ontario, British
Columbia and Alberta.

 

(d)               
This Subscription Agreement, when accepted by the Corporation, will constitute a legal, valid and binding obligation of the Corporation
enforceable in accordance with its terms.

 

(e)                
The execution and delivery of, and the performance of the terms of this Subscription Agreement by the Corporation, including the
issue of the Securities, does not and will not constitute a breach of or default under the constating documents of the Corporation or
any law, regulation, order or ruling applicable to the Corporation or any agreement, contract or indenture to which the Corporation is
a party or by which it is bound.

 

    Page 5 

     

    

 

(f)                 
 The Corporation is not a party to any actions, suits or proceedings which could materially affect its business or financial condition,
and, as at the date hereof, no such actions, suits or proceedings have been threatened or, to the best of the Corporation’s knowledge,
are pending, except as disclosed in information which has been filed by the Corporation with the various Canadian securities commissions
under applicable securities legislation and the Exchange.

 

(g)               
The sale, issuance and delivery of the Units at the closing (the “Closing”) will have been approved by all requisite
corporate action on or before the Closing Date and, upon issue and delivery at the Closing, the Units will be validly issued as fully
paid and non-assessable.

 

(h)               
No order ceasing or suspending trading in the Securities nor prohibiting sale of the Securities has been issued to and is outstanding
against the Corporation or its directors, officers or promoters and to the best of the Corporation’s knowledge no investigations
or proceedings for such purposes are pending or threatened.

 

Acknowledgements, Warranties and Covenants of the Subscriber

 

4.                                 The Subscriber acknowledges, warrants and agrees (on its own behalf and, if applicable, on behalf of each person on whose behalf
the Subscriber is contracting) that:

 

(a)                
the Offering, of which this Subscription Agreement forms a part, is not subject to a minimum subscription level and as such, upon
acceptance by the Corporation, subscription funds are immediately available for use by the Corporation;

 

(b)               
no fractional Warrants shall be issued and the Corporation shall round down any fractional number of Warrants to the nearest whole
number;

 

(c)                
the Corporation may complete additional financings in the future which may have a dilutive effect on existing shareholders at such
time, including a Subscriber hereunder;

 

(d)               
it is aware of the characteristics of the Units, the risks relating to an investment therein and of the fact that it may not be
able to resell the Securities except in accordance with limited exemptions under applicable securities legislation and regulatory policy
until expiry of the applicable restriction period and compliance with the other requirements of applicable law, and it agrees that any
certificates (or DRS) representing the Securities may bear the following legend indicating that the resale of such Securities is restricted:

 

“Unless
permitted under securities legislation, the holder of this security must not trade the security before [that
date that is 4 months and a day after the Closing Date].”

 

(e)                
the Closing is subject to the terms of the conditional approval of the Exchange;

 

(f)                 
the Corporation may pay fees or issue finder warrants or both to one or more finders in accordance with the policies of the Exchange
in connection with the Offering and subject to compliance with applicable securities laws;

 

(g)               
the issuance of the Units shall be subject to any conditions that may be imposed by the Exchange as part of the Exchange’s
acceptance of the Offering, including, without limitation, the conditions noted in paragraphs 4(h) and 4(i);

 

(h)               
in the event that the issuance of the Units hereunder may result in, or be part of a transaction that may result in, either or
both

 

(i)                 
the issuance of listed Shares representing more than 25% of the number of Shares which are outstanding on a non-diluted basis prior
to the Closing; or

 

(ii)               
 the issuance of listed Shares during any six month period to insiders representing more than
10% of the number of Shares which are outstanding on a non-diluted basis prior to the Closing;

 

    Page 6 

     

    

 

the Exchange may require
as a condition of its acceptance of the Offering that the Corporation obtain shareholder approval (excluding, in the case of the 10% Insider
Rule, the votes attached to the Shares held by Insiders and their associates and affiliates); and

 

(i)                 
in the event that the issuance of the Units may result in, or be part of a transaction that may result in, the creation of a new
 “Insider” or a new “Control Person”, the Exchange may require as a condition of its acceptance of the Offering,
that the Corporation obtain shareholder approval (excluding the votes attached to the Units held by the new Insider or new Control Person
and its associates and affiliates) of the new Insider or new Control Person, as the case may be, prior to the issue of a portion or all
of the Units.

 

5.                                 The Subscriber (on its own behalf and, if applicable, on behalf of each person on whose behalf the Subscriber is contracting) represents,
warrants and covenants to the Corporation that:

 

(a)                
it has been independently advised as to the restrictions with respect to trading in the Securities imposed by applicable securities
legislation, and no representation has been made to it by or on behalf of the Corporation with respect thereto;

 

(b)               
it has not received or been provided with, nor has it requested, nor does it have any need to receive, any prospectus or offering
memorandum, or any other document describing the business and affairs of the Corporation which has been prepared for delivery to, and
review by, prospective purchasers in order to assist it in making an investment decision in respect of the Units;

 

(c)                
it has relied solely upon information publicly available on SEDAR (at www.sedar.com) relating to the Corporation and not
upon any oral or written representation as to fact or otherwise made by or on behalf of the Corporation and it does not have knowledge
of any “material fact” (as defined under applicable securities legislation) about the Corporation that has not been publicly
disclosed;

 

(d)               
the Subscriber is resident in the province set out in the “Subscriber’s Address”, which is the ordinary residence
or place of business of the Subscriber and such beneficial purchaser, if applicable, and, if the Subscriber is a corporate entity, it
was not created nor is it used solely for the purpose of acquiring the Units;

 

(e)                
the Subscriber is purchasing the Units to be held for investment purposes only and not with a view to immediate resale or distribution
and will not recall or otherwise transfer or dispose of the Units except in accordance with the provisions of applicable securities legislation;

 

(f)                 
the Subscriber is purchasing the Units as principal for its own account, it is purchasing such Units for investment only and not
for the benefit of any other person and not with a view to the resale or distribution of all or any of the Units and it fully complies
with one or more of the sub-paragraphs set forth below:

 

(i)                 
the Subscriber

 

(A)              
is an “accredited investor” within the meaning of applicable securities laws, including National Instrument 45-106
entitled “Prospectus and Registration Exemptions” (“NI 45-106”); and

 

(B)              
has concurrently executed and delivered a Representation Letter in the form attached as Schedule I to this Subscription Agreement,
including Appendix “A” and Appendix “B” thereto; or

 

(ii)               
the Subscriber is neither an individual nor a company established solely to acquire the Units and the cost of the Units purchased
by it has an aggregate acquisition of not less than $150,000; or

 

(iii)             
 __________ (to be initialled by Subscriber, if applicable) - if it is not purchasing under subparagraph 5(f)(i), or (ii),
it is purchasing pursuant to an exemption from prospectus and registration requirements (particulars of which are enclosed herewith or
will be provided on or before the Closing Date) available to it under applicable securities legislation and shall deliver to the Corporation
such further particulars of the exemption(s) and the Subscriber’s qualifications thereunder as the Corporation may request;

 

    Page 7 

     

    

 

(g)               
if it is not purchasing as principal (and is not otherwise deemed to be purchasing as principal for the purposes of the applicable
prospectus exemption under applicable provincial and territorial securities laws in Canada),

 

(i)                 
it is duly authorized to enter into this Subscription Agreement and to execute all documentation in connection with the purchase
on behalf of each beneficial purchaser, each of whom is purchasing as principal for its own account, not for the benefit of any other
person, and not with a view to the resale or distribution of all or any of the Securities;

 

(ii)               
it and each beneficial purchaser has provided to the Corporation all of the information required by pages 1 to 3 of this Subscription
Agreement and it acknowledges that the Corporation may be required by law to disclose to certain regulatory authorities the identity of
each beneficial purchaser of Units for whom it may be acting; and

 

(iii)             
each of the principals complies with one or more of subparagraphs 5(f)(i) through (f)(ii), as applicable, and the same is so indicated
for each such principal;

 

(h)               
if the Subscriber is a resident of a country other than Canada or the United States (a “Jurisdiction Outside CAN-US”)
then in addition to the other representations and warranties contained herein, the Subscriber represents and warrants that:

 

(i)                 
the Subscriber is knowledgeable of, or has been independently advised as to, the applicable securities laws of the Jurisdiction
Outside CAN-US which would apply to this Subscription Agreement, if any;

 

(ii)               
the Subscriber is purchasing the Subscriber’s Shares pursuant to exemptions from any prospectus, registration or similar
requirements under the applicable securities laws of that Jurisdiction Outside CAN-US or, if such is not applicable, the Subscriber is
permitted to purchase the Subscriber’s Shares under the applicable securities laws of the Jurisdiction Outside CAN-US without the
need to rely on an exemption;

 

(iii)             
the applicable securities laws of the Jurisdiction Outside CAN-US in which the Subscriber resides do not require the Corporation
to file a prospectus, registration statement or similar document or to register the Securities or to make any filings or seek any approvals
of any kind whatsoever from any regulatory authority of any kind whatsoever in the Jurisdiction Outside CAN-US;

 

(iv)              
the delivery of this Subscription Agreement, the acceptance of it by the Corporation and the issuance of the Securities to the
Subscriber complies with all applicable laws of the Subscriber’s jurisdiction of residence or domicile and all other applicable
laws and will not cause the Subscriber to become subject to or comply with any disclosure, prospectus or other offering document or reporting
requirements under any such applicable laws; and

 

(v)               
the Subscriber will, if requested by the Corporation, or its counsel deliver to the Corporation a certificate or opinion of local
counsel from the Jurisdiction Outside CAN-US in which the Subscriber resides which will confirm the matters referred to in subsections
(ii), (iii) and (iv) above to the satisfaction of the Corporation and its counsel, acting reasonably

 

(i)                 
it acknowledges that:

 

(i)                 
no securities commission or similar regulatory authority has reviewed or passed on the merits of the Units;

 

    Page 8 

     

    

 

 

(ii)               
 there is no government or other insurance covering the Units;

 

(iii)             
there are risks associated with the purchase of the Units;

 

(iv)              
there are restrictions on the Subscriber’s ability to resell the Securities and it is the responsibility of the Subscriber
to find out what those restrictions are and to comply with them before selling any of the Securities; and

 

(v)               
the Corporation or its agent has advised the Subscriber that the Corporation is relying on an exemption from the requirements to
provide the Subscriber with a prospectus and (except for Subscribers who qualify for a prospectus exemption herein by virtue of being
advised by a registered dealer) to sell the Units through a person or company registered to sell securities under applicable provincial
and territorial securities laws in Canada (including the Securities Act (Ontario) and, as a consequence of acquiring the Units
pursuant to this exemption, certain protections, rights and remedies provided by the Acts, including statutory rights of rescission or
damages, will not be available to the Subscriber;

 

(j)            if
a corporation, partnership, unincorporated association or other entity, it has the legal capacity to enter into and be bound by this
Subscription Agreement and further certifies that all necessary approvals of directors, shareholders, partners or otherwise have been
given and obtained;

 

(k)          if an individual, it is of the full age of majority and is legally competent to execute this Subscription Agreement and take all
action pursuant hereto;

 

(l)           this Subscription Agreement has been duly and validly authorized, executed and delivered by and constitutes a legal, valid, binding
and enforceable obligation of the Subscriber;

 

(m)              
in the case of a subscription by it for Units acting as agent for a disclosed principal, it is duly authorized to execute and deliver
this Subscription Agreement and all other necessary documentation in connection with such subscription on behalf of such principal and
this Subscription Agreement has been duly authorized, executed and delivered by or on behalf of, and constitutes a legal, valid and binding
agreement of, such principal;

 

(n)          
it acknowledges that no representation has been made to it:

 

(i)               as
to the future value or price of the Shares;

 

(ii)              that
any person will resell or repurchase the Shares; or;

 

(iii)            
that any person will refund the purchase price of the Shares;

 

(o)         
it has such knowledge in financial and business affairs as to be capable of evaluating the merits and risks of its investment and
it, or where it is not purchasing as principal, each beneficial purchaser, is able to bear the economic risk of loss of its investment;

 

(p)         it understands that the Units are being offered for sale only on a “private placement” basis and that the sale and
delivery of the Units is conditional upon such sale being exempt from the requirements as to the filing of a prospectus or the preparation
of an offering memorandum in prescribed form or upon the issuance of such orders, consents or approvals as may be required to permit such
sale without the requirement of filing a prospectus or delivering an offering memorandum in prescribed form and that certain protections,
rights and remedies provided by applicable securities legislation, in connection with the filing of a prospectus may not be available
to the Subscriber;

 

(q)          if
required by applicable securities legislation, regulations, rules, policies or orders or by any securities commission, stock exchange
or other regulatory authority, the Subscriber will execute, deliver, file and otherwise assist the Corporation in filing, such reports,
undertakings and other documents with respect to the issue of the Units as may be required;

 

    Page 9

     

    

 

(r)           
 the entering into of this Subscription Agreement and the transactions contemplated hereby will not result in a violation of any
of the terms or provisions of any law applicable to the Subscriber, or if the Subscriber is not a natural person, any of the Subscriber’s
constating documents, or any agreement to which the Subscriber is a party or by which it is bound;

 

(s)          the funds representing the Aggregate Subscription Amount which will be advanced by the Subscriber hereunder will not represent
proceeds of crime for the purposes of the Proceeds of Crime (Money Laundering) Act (Canada) and the Subscriber acknowledges that
the Corporation may in the future be required by law to disclose the Subscriber’s name and other information relating to this Subscription
Agreement and the Subscriber’s subscription hereunder, on a confidential basis, pursuant to the Proceeds of Crime (Money Laundering)
Act (Canada) and to the best of the Subscriber’s knowledge (i) none of the subscription funds to be provided by the Subscriber
(A) have been or will be derived from or related to any activity that is deemed criminal under the law of Canada, the United States of
America, or any other jurisdiction, or (B) are being tendered on behalf of a person or entity who has not been identified to the Subscriber,
and (ii) it shall promptly notify the Corporation if the Subscriber discovers that any of such representations ceases to be true, and
to provide the Corporation with appropriate information in connection therewith;

 

(t)           the
Corporation’s counsel, McMillan LLP, is acting solely for the Corporation and in connection with the Offering and the Subscriber
may not rely upon McMillan LLP in any respect. The Subscriber acknowledges that it has been encouraged to and should obtain independent
legal, income tax and investment advice with respect to its subscription for Units and accordingly, has been independently advised as
to the meanings of all terms contained herein relevant to the Subscriber for the purposes of giving representations, warranties and covenants
under this Subscription Agreement;

 

(u)          the
information provided by the Subscriber on pages 1, 2 and 3 of this Subscription Agreement and under the heading “Information Regarding
The Subscriber” is true and correct in all material respects and will be true and correct as of the Closing Date;

 

(v)          it does not act jointly or in concert with any other Subscriber under the Offering for the purposes of the acquisition of the Units;

 

(w)         it will not resell the Securities or any of them, except in accordance with the provisions of applicable securities legislation
and stock exchange rules, if applicable, in the future;

 

(x)          the delivery of this subscription, the acceptance hereof by the Corporation and the issuance of the Units to the Subscriber complies
with all applicable laws of the Subscriber’s jurisdiction of residence and domicile and will not cause the Corporation or any of
its officers or directors to become subject to or require any disclosure, prospectus or other reporting requirement;

 

(y)          the
Corporation may complete additional financings in the future in order to develop the business of the Corporation and to fund its ongoing
development; there is no assurance that such financings will be available and, if available, on reasonable terms; any such future financings
may have a dilutive effect on current securityholders, including the Subscriber; and if such future financings are not available, the
Corporation may be unable to fund its ongoing development and the lack of capital resources may result in the failure of its business
venture; and

 

(z)          the Subscriber is capable of assessing the proposed investment as a result of the Subscriber’s financial experience or as
a result of advice received from a registered person other than the Corporation or any affiliates thereof.

 

Closing

 

6.                          The
Subscriber agrees to deliver to the Corporation, not later than the Closing Time: (a) this duly completed and executed Subscription
Agreement, including all applicable Schedules hereto and Appendices thereto; and (b) the Aggregate Subscription Amount subscribed
for under this Subscription Agreement in accordance with the Instructions on the Cover Page or payment of the same amount in such
other manner as is acceptable to the Corporation. If payment is made in a currency other than Canadian dollars, the Subscriber
acknowledges and agrees that it shall be responsible to make up for any deficiency in the payment of the Aggregate Subscription
Price as a result of the exchange of such funds into Canadian dollars.

 

    Page 10

     

    

 

7.                              
The sale of the Units pursuant to this Subscription Agreement will be completed at the offices of McMillan LLP, the Corporation’s
counsel, in Vancouver, British Columbia at 10:00 a.m. (Vancouver time) or such other time as the Corporation may determine (the “Closing
Time”) on such date (the “Closing Date”) the Corporation may determine within 45 days of its acceptance of
this Subscription Agreement. The Corporation may complete the Offering in one or more Closings. At the Closing Time, the Corporation will
deliver, or cause to be delivered, according to the instructions set out under Delivery Instructions herein the certificates (or DRS)
representing the Units as registered in the name of the Subscriber or its nominee as set out under Registration Instructions provided
that the Subscriber shall have delivered to the Corporation the completed Subscription Agreement and the Aggregate Subscription Amount.

 

8.                             The
obligations of the parties hereunder are subject to acceptance of the terms of the Offering by the Exchange.

 

9.                             The Corporation shall be entitled to rely on delivery of a copy of executed subscriptions by electronic means, and acceptance by
the Corporation of such electronic subscriptions (including, without limitation by facsimile or email delivery) shall be legally effective
to create a valid and binding agreement between the Subscriber and the Corporation in accordance with the terms hereof. Prior to Closing,
any funds advanced to the Corporation on account of the Aggregate Subscription Amount shall constitute a non-interest bearing loan to
the Corporation, which loan shall be due and payable to the Subscriber on the request of the Subscriber in the event that the Closing
does not occur within 90 days of its acceptance of this Subscription Agreement.

 

Privacy Legislation

 

(a)                           The
Subscriber acknowledges and consents to the fact that the Corporation is collecting the Subscriber’s (and any Disclosed Principal
for whom the Subscriber is acting hereunder) personal information (as that term is defined under applicable privacy legislation, including,
without limitation, the Personal Information Protection and Electronic Documents Act (Canada) and any other applicable similar
replacement or supplemental provincial or federal legislation or laws in effect from time to time) for the purpose of completing the
Subscriber’s subscription. The Subscriber acknowledges and consents to the Corporation retaining the personal information for so
long as permitted or required by applicable law or business practices. The Subscriber further acknowledges and consents to the fact that
the Corporation may be required by applicable securities legislation, stock exchange rules and/or Investment Industry Regulatory Organization
of Canada rules to provide regulatory authorities with any personal information provided by the Subscriber respecting itself (and any
Disclosed Principal for whom the Subscriber is acting hereunder). The Subscriber represents and warrants that it has the authority to
provide the consents and acknowledgements set out in this paragraph on behalf of all Disclosed Principals for whom the Subscriber is
acting. In addition to the foregoing, the Subscriber agrees and acknowledges that the Corporation may use and disclose the Subscriber’s
personal information, or that of each Disclosed Principal for whom the Subscriber is acting hereunder, as follows:

 

(i)           for internal use with respect to managing the relationships between and contractual obligations of the Corporation and the Subscriber
or any Disclosed Principal for whom the Subscriber is acting hereunder;

 

(ii)          
for use and disclosure to the Corporation’s transfer agent and registrar;

 

(iii)         for use and disclosure for income tax related purposes, including without limitation, where required by law, disclosure to Canada
Revenue Agency;

 

(iv)         disclosure to securities regulatory authorities (including the TSX) and other regulatory bodies with jurisdiction with respect
to reports of trade and similar regulatory filings;

 

(v)           disclosure to a governmental or other authority (including the TSX) to which the disclosure is required by court order or subpoena
compelling such disclosure and where there is no reasonable alternative to such disclosure;

 

(vi)         disclosure to professional advisers of the Corporation in connection with the performance of their professional services;

 

    Page 11

     

    

 

(vii)         
 disclosure to any person where such disclosure is necessary for legitimate business reasons and is made with the Subscriber’s
prior written consent;

 

(viii)       disclosure to a court determining the rights of the parties under this Subscription Agreement; or

 

(ix)          for use and disclosure as otherwise required or permitted by law.

 

The Subscriber further acknowledges
and agrees that the TSX collects personal information in forms submitted by the Corporation, which will include personal information
regarding the Subscriber. The Subscriber agrees that the TSX may use this information in the manner provided for in Appendix 6A to the
TSX Company Manual, a copy of which may be viewed at the TSX website, www.tsx.com and is incorporated herein by reference. The
Subscriber further acknowledges that the securities regulatory authorities, including, without limitation, the British Columbia Securities
Commission, the Alberta Securities Commission and the Ontario Securities Commission, collect personal information in forms submitted
to it by the Corporation, including information about the Subscriber, the Subscriber’s address and contact information, and the
Subscriber’s subscription. The Subscriber acknowledges that any such securities commission is entitled to collect the information
under authority granted to each respective regulatory authority under applicable securities legislation for the purpose of administration
and enforcement of the applicable securities legislation. The Subscriber acknowledges that it may obtain information regarding the collection
of this information by contacting, in the case of the British Columbia Securities Commission, British Columbia Securities Commission,
P.O. Box 10142, Pacific Centre, 701 West Georgia Street, Vancouver, British Columbia, V7Y 1L2, Telephone: (604) 899-6500 or (800) 373-6393,
Facsimile: (604) 899-6581, in the case of the Alberta Securities Commission, Alberta Securities Commission, Suite 600, 250 –
5th St. SW, Calgary, Alberta, T2P 0R4, Telephone: (403) 355-4151, Facsimile: (403) 297-6156, and, in the case of the Ontario
Securities Commission, the Administrative Assistant to the Director of Corporate Finance, Ontario Securities Commission, Suite 1903,
Box 5520, Queen Street West, Toronto, Ontario M5H 3S8, Telephone: (416) 593-3682, Facsimile: (416) 593-8252. The Subscriber
consents to the collection of personal information by the applicable securities regulatory authorities, including, without limitation,
the British Columbia Securities Commission, the Alberta Securities Commission and the Ontario Securities Commission.

 

General

 

10.                         The
Subscriber agrees that the representations, warranties and covenants of the Subscriber herein will be true and correct both as of the
execution of this Subscription Agreement and as of the Closing Time and will survive the issuance of the Units. The representations,
warranties and covenants of the Subscriber herein are made with the intent that they be relied upon by the Corporation in determining
the eligibility of a purchaser of Units and the Subscriber agrees to indemnify the Corporation against all losses, claims, costs, expenses
and damages or liabilities which it may suffer or incur which are caused or arise from an inaccuracy or breach thereof and reliance thereon.
The Subscriber undertakes to immediately notify the Corporation by written notice to ProMIS Neurosciences Inc. sent to its office at
1920 Yonge Street, Suite 200, Toronto, ON M4S 3E2 or by email to [***] of any change in any
statement or other information relating to the Subscriber set forth herein which takes place prior to the Closing Time.

 

11.                           The
Subscriber acknowledges and agrees that all costs incurred by the Subscriber (including any fees and disbursements of any counsel retained
by the Subscriber) relating to the sale of the Units to the Subscriber shall be borne by the Subscriber.

 

12.                           The
Subscriber acknowledges that upon a subscription being accepted by the Corporation, the Corporation will, subject to the terms and conditions
set out herein, issue to the Subscriber certificates (or DRS) evidencing the Subscriber’s ownership of the Units.

 

13.                           The
terms and provisions of this Subscription Agreement shall be binding upon and enure to the benefit of the Subscriber and the Corporation
and their respective heirs, executors, administrators, successors and permitted assigns

 

14.                            The
contract arising out of this Subscription Agreement and all documents relating thereto shall be governed by and construed in accordance
with the laws of the Province of British Columbia and the federal laws of Canada applicable therein. The parties irrevocably attorn to
the exclusive jurisdiction of the courts of the Province of British Columbia.

 

    Page 12

     

    

 

15.                          
Time is of the essence of this Subscription Agreement.

 

16.                           Neither party to this Subscription Agreement may assign all or part of its interest in or to this Subscription Agreement without
the consent in writing of the other party hereto, except for the assignment by a Subscriber who is acting as nominee or agent to the beneficial
owner and as otherwise herein provided.

 

17.                           This
Subscription Agreement represents the entire agreement of the parties hereto relating to the subject matter hereof and there are no representations,
covenants or other agreements relating to the subject matter hereof except as stated or referred to herein. Neither this Subscription
Agreement nor any provision hereof shall be modified, changed, discharged or terminated except by an instrument in writing signed by
the party against whom any waiver, change, discharge or termination is sought.

 

18.                           The covenants, representations and warranties contained herein shall survive the closing of the transactions contemplated hereby.

 

19.                           
In this Subscription Agreement (including attachments), references to “$” or “Cdn. $” are to Canadian dollars.

 

20.                           The
parties hereto acknowledge and confirm that they have requested that this Subscription Agreement as well as all notices and other documents
contemplated hereby be drawn up in the English language. Les parties aux présentes reconnaissent et confirment qu’elles
ont convenu que la présente convention de souscription ainsi que tous les avis et documents qui s’y rattachent soient rédigés
dans la langue anglaise.

 

    Page 13

     

    

 

SCHEDULE I

REPRESENTATION LETTER

(FOR CANADIAN ACCREDITED INVESTORS)

 

		TO:	ProMIS Neurosciences Inc. (the “Corporation”)

 

In connection with the purchase of units of
the Corporation (“Units”) by the undersigned subscriber or, if applicable, the principal on whose behalf the
undersigned is purchasing as agent (the “Subscriber” for the purposes of this Schedule I), the Subscriber hereby
represents, warrants, covenants and certifies to the Corporation that:

 

		1.	The Subscriber is purchasing the Units as principal for its own account or is deemed to be acting as principal
pursuant to applicable securities laws, including National Instrument 45-106 entitled “Prospectus and Registration Exemptions”
(“NI 45-106”);

 

		2.	The Subscriber is an “accredited investor” within the meaning of applicable securities
laws, including NI 45-106, by virtue of satisfying one or more of the categories set out in Appendix “A” to this Representation
Letter;

 

		3.	If the Subscriber is an individual, he or she has completed the attached Form 45-106F9 -- Form for
Individual Accredited Investors set out in Appendix “B” to this Representation Letter unless the individual qualifies
under a category set out in Appendix “A” other than (j), (k) or (l) of the definition of “accredited investor”;
and

 

		4.	Upon execution of this Schedule I by the Subscriber, this Schedule I shall be incorporated into and form
a part of the Subscription Agreement.

 

Dated: _______________________, 2018.

 

	 	Print name of Subscriber
	 	 
	 	By:	 
	 	 	Signature
	 	 
	 	 	 
	 	 	Print name of Signatory (if different from Subscriber)
	 	 
	 	 	 
	 	 	Title

 

IMPORTANT: PLEASE INITIAL APPENDIX “A”
OVER PAGE

 

    Page 1

     

    

 

APPENDIX “A”

TO SCHEDULE 1

 

NOTE: THE SUBSCRIBER MUST INITIAL BESIDE THE APPLICABLE PORTION
OF THE DEFINITION BELOW AND COMPLETE EACH QUESTION WHICH FOLLOWS THE APPLICABLE PORTION OF THE DEFINITION.

 

Accredited Investor – (as defined in National Instrument
45-106, and in Ontario, as defined in Section 73.3 of the Securities Act (Ontario) as supplemented by the definition in National
Instrument 45-106) includes:

 

	_______	(a)	except in Ontario, a Canadian financial institution, or a Schedule III bank,
	_______	(a.1)	in Ontario, a financial institution described in paragraph 1, 2 or 3 of subsection 73.1 (1) of the Securities Act (Ontario),
	_______	(b)	except in Ontario, the Business Development Bank of Canada incorporated under the Business Development Bank of Canada Act (Canada),
	_______	(b.1)	in Ontario, the Business Development Bank of Canada,
	_______	(c)	except in Ontario, a subsidiary of any person referred to in paragraphs (a) or (b), if the person owns all of the voting securities of
the subsidiary, except the voting securities required by law to be owned by directors of that subsidiary,
	_______	(c.1)	in Ontario, a subsidiary of any person or Corporation referred to in clause (a.1) or (b.1), if the person or Corporation owns all of
the voting securities of the subsidiary, except the voting securities required by law to be owned by directors of that subsidiary,
	_______	(d)	except in Ontario, a person registered under the securities legislation of a jurisdiction of Canada as an adviser or dealer,
	_______	(d.1)	in Ontario, a person or Corporation registered under the securities legislation of a province or territory of Canada as an adviser or
dealer, except as otherwise prescribed by the regulations,
	_______	(e)	an individual registered under the securities legislation of a jurisdiction of Canada as a representative of a person referred to in
paragraph (d),
	_______	(e.1)	an individual formerly registered under the securities legislation of a jurisdiction of Canada, other than an individual formerly registered
solely as a representative of a limited market dealer under one or both of the Securities Act (Ontario) or the Securities Act
(Newfoundland and Labrador),
	_______	(f)	except in Ontario, the Government of Canada or a jurisdiction of Canada, or any crown corporation, agency or wholly owned entity of the
Government of Canada or a jurisdiction of Canada,
	_______	(f.1)	in Ontario, the Government of Canada, the government of a province or territory of Canada, or any Crown corporation, agency or wholly
owned entity of the Government of Canada or of the government of a province or territory of Canada,

	_______	(g)	a municipality, public board or commission in Canada and a metropolitan community, school board, the Comité de gestion de la taxe
scolaire de l’île de Montréal or an intermunicipal management board in Québec,

 

    

     

    

 

	_______	(h)	any national, federal, state, provincial, territorial or municipal government of or in any foreign jurisdiction, or any agency of that
government,
	_______	(i)	except in Ontario, a pension fund that is regulated by the Office of the Superintendent of Financial Institutions (Canada), a pension
commission or similar regulatory authority of a jurisdiction of Canada,
	_______	(i.1)	 in Ontario, a pension fund that is regulated by either the Office of the Superintendent of Financial Institutions (Canada) or a pension
commission or similar regulatory authority of a province or territory of Canada,
	_______	
    (j)       
	an individual
                                                                                                                                                                                   who, either alone or with a spouse, beneficially owns financial assets having an aggregate realizable value that before taxes, but
                                                                                                                                                                                   net of any related liabilities, exceeds $1,000,000,

     

    [If this is your
    applicable category, you must also complete Form 45-106F9 attached as Appendix B]

     

	_______	(j.1)	an individual who beneficially owns financial assets having an aggregate realizable value that, before taxes but net of any related liabilities,
exceeds $5,000,000,
	_______	
    (k)       
	an
    individual whose net income before taxes exceeded $200,000 in each of the 2 most recent calendar years or whose net income before taxes
    combined with that of a spouse exceeded $300 000 in each of the 2 most recent calendar years and who, in either case, reasonably expects
    to exceed that net income level in the current calendar year,

     

    [If this is your
    applicable category, you must also complete Form 45-106F9 attached as Appendix B]

     

	_______	
    (l)
	an individual
    who, either alone or with a spouse, has net assets of at least $5,000,000,

     

    [If this is your
    applicable category, you must also complete Form 45-106F9 attached as Appendix B]

     

	_______	(m)	a person, other than an individual or investment fund, that has net assets of at least $5,000,000 as shown on its most recently prepared
financial statements,
	_______	
    (n)       
	an
    investment fund that distributes or has distributed its securities only to:

     

    (i)      a
    person that is or was an accredited investor at the time of the distribution,

     

    (ii)     a
    person that acquires or acquired securities in the circumstances referred to in sections 2.10 [Minimum amount investment], or  2.19 [Additional
    investment in investment funds], or

     

    (iii)    a
    person described in paragraph (i) or (ii) that acquires or acquired securities under section 2.18 [Investment fund
    reinvestment],  

     

	_______	(o)	an investment fund that distributes or has distributed securities under a prospectus in a jurisdiction of Canada for which the regulator
or, in Québec, the securities regulatory authority, has issued a receipt,

 

    

     

    

 

	_______	(p)	a trust Corporation or trust corporation registered or authorized to carry on business under the Trust and Loan Companies Act
(Canada) or under comparable legislation in a jurisdiction of Canada or a foreign jurisdiction, acting on behalf of a fully managed account
managed by the trust Corporation or trust corporation, as the case may be,
	_______	(q)	a person acting on behalf of a fully managed account managed by that person, if that person is registered or authorized to carry on business
as an adviser or the equivalent under the securities legislation of a jurisdiction of Canada or a foreign jurisdiction,
	_______	(r)	a registered charity under the Income Tax Act (Canada) that, in regard to the trade, has obtained advice from an eligibility adviser
or an adviser registered under the securities legislation of the jurisdiction of the registered charity to give advice on the securities
being traded,
	_______	(s)	an entity organized in a foreign jurisdiction that is analogous to any of the entities referred to in paragraphs (a) to (d) paragraph
(i) [and in Ontario, paragraphs (a.1) to (d.1) or paragraph (i.1)] in form and function,
	_______	(t)	a person in respect of which all of the owners of interests, direct, indirect or beneficial, except the voting securities required by
law to be owned by directors, are persons that are accredited investors
	_______	(u)	an investment fund that is advised by a person registered as an adviser or a person that is exempt from registration as an adviser,
	_______	(v)	a person that is recognized or designated by the securities regulatory authority or, except in Ontario and Québec, the regulator
as an accredited investor,
	_______	(v.1)	in Ontario, a person or Corporation that is recognized or designated by the Commission as an accredited investor,
	_______	(w)	a trust established by an accredited investor for the benefit of the accredited investor’s family members of which a majority of
the trustees are accredited investors and all of the beneficiaries are the accredited investor’s spouse, a former spouse of the
accredited investor or a parent, grandparent, brother, sister, child or grandchild of that accredited investor, of that accredited investor’s
spouse or of that accredited investor’s former spouse.

 

Dated: __________________, 201__.

 

 

	Print name of Subscriber	 
	 	 
	 	 
	Signature	 
	 	 
	 	 
	Print name of Signatory (if different from Subscriber)	 
	 	 
	 	 
	Title	 

 

    

     

    

 

For the purposes hereof:

 

	 	
    “control person” has the meaning ascribed to that
    term in securities legislation except in Manitoba, Ontario, Quebec, Nova Scotia, Newfoundland and Labrador, Prince Edward Island, the
    Northwest Territories and Nunavut where “control person” means any person that holds or is one of a combination of persons
    that hold:

     

	 	(i)  	a sufficient number of any of the securities of an issuer so as to affect materially the control of the issuer; or
	 	(ii) 	
    more than 20% of the outstanding voting securities of an issuer except
    where there is evidence showing that the holding of those securities does not affect materially the control of that issuer;

     

	 	“eligibility adviser” means:

                                                                                 

	 	(i)  	a person that is registered as an investment dealer or in an equivalent category of registration under the securities legislation of the jurisdiction of a Subscriber and authorized to give advice with respect to the type of security being distributed; and
	 	(ii) 	in Saskatchewan or Manitoba, also means a lawyer who is a practicing member in good standing with a law society of a jurisdiction of Canada or a public accountant who is a member in good standing of an institute or association of chartered accountants, certified general accountants or certified management accountants in a jurisdiction of Canada provided that the lawyer or public accountant must not:

                                                                                 

	 	(A)	have a professional, business or personal relationship with the issuer, or any of its directors, executive officers, founders or control persons; and
	 	(B)    	
    have acted for or been retained personally or otherwise as an employee,
    executive officer, director, associate or partner of a person that has acted for or been retained by the issuer or any of its directors,
    executive officers, founders or control persons within the previous 12 months;

     

	 	
    “financial assets” means (i) cash, (ii) securities
    or (iii) a contract of insurance, a deposit or an evidence of a deposit that is not a security for the purposes of securities legislation.
    These financial assets are generally liquid or relatively easy to liquidate. The value of a purchaser’s personal residence would
    not be included in a calculation of financial assets;

     

	 	
    “financial statements” for the purposes of paragraph
    (m) of the “accredited investor” definition must be prepared in accordance with generally accepted accounting principles;

     

	 	“founder” means, in respect of an issuer, a person who:

                                                                                 

	 	(i)       	acting alone, in conjunction or in concert with one or more persons, directly or indirectly, takes the initiative in founding, organizing or substantially reorganizing the business of the issuer; and
	 	(ii)    	
    at the time of the trade is actively involved in the business of the
    issuer;

     

	 	
    “fully managed account” means an account of a client
    for which a person makes the investment decisions if that person has full discretion to trade in securities for the account without requiring
    the client’s express consent to a transaction;

     

	 	
    “investment fund” has the meaning ascribed thereto
    in National Instrument 81-106 - Investment Fund Continuous Disclosure;

     

	 	
    “net assets” means all
of the purchaser’s total assets minus all of the purchaser’s total liabilities. Accordingly, for the purposes of the net
asset test, the calculation of total assets would include the value of a purchaser’s personal residence and the calculation of
total liabilities would include the amount of any liability (such as a mortgage) in respect of the purchaser’s personal residence.
To calculate a purchaser’s net assets under the “accredited investor” definition, subtract the purchaser’s total
liabilities from the purchaser’s total assets (including real estate). The value attributed to assets should reasonably reflect
their estimated fair value. Income tax should be considered a liability if the obligation to pay it is outstanding at the time of the
distribution of the security; 

 

    

     

    

 

	 	“related liabilities” means:

                                                                                 

	 	(i)         	liabilities incurred or assumed for the purpose of financing the acquisition or ownership of financial assets; or
	 	(ii)      	
    liabilities that are secured by financial assets;

     

	 	“spouse” means an individual who:

                                                                                 

	 	(i)        	is married to another individual and is not living separate and apart within the meaning of the Divorce Act (Canada), from the other individual; 
	 	(ii)        	is living with another individual in a marriage-like relationship, including a marriage-like relationship between individuals of the same gender; or
	 	(iii)       	
    in Alberta, is an individual referred to
in paragraph (i) or (ii) immediately above or is an adult interdependent partner within the meaning of the Adult Interdependent Relationships
Act (Alberta); and 

 

    

     

    

 

APPENDIX “B”

TO SCHEDULE 1

 

Form 45-106F9 - Form for Individual Accredited
Investors

 

	
     

    WARNING!

     

    This investment is risky. Don’t invest
    unless you can afford to lose all the money you pay for this investment.

 

	SECTION 1 TO BE COMPLETED BY ISSUER OR SELLING SECURITY HOLDER
	1.       About your investment
	Type of securities:   Common Shares and Warrants	Issuer:  ProMIS Neurosciences Inc.
	SECTIONS 2 TO 4 TO BE COMPLETED BY THE PURCHASER
	2.       Risk acknowledgement
	This investment is risky. Initial that you understand that:	Your 

initials
	Risk of loss – You could lose your entire investment of $________. 	 
	Liquidity risk – You may not be able to sell your investment quickly – or at all.	 
	Lack of information – You may receive little or no information about your investment.	 
	Lack
    of advice – You may not receive advice from the salesperson about whether this investment is suitable for you unless the
    salesperson is registered. The salesperson is the person who meets with, or provides information to, you about making this investments.
    To check whether the salesperson is registered, go to www.aretheyregistered.ca.	 
	3.       Accredited investor status
	You must meet at least one of the following criteria to be able to make this investment. Initial the statement that applies to you. (You may initial more than one statement.) The person identified in section 6 is responsible for ensuring that you meet the definition of accredited investor. That person, or the salesperson identified in section 5, can help you if you have questions about whether you meet these criteria.	Your

 initials
	·      Your
net income before taxes was more than $200,000 in each for the 2 most recent calendar years, and you expect it to be more than $200,000
in the current calendar year. (You can find your net income before taxes on your personal income tax return.)	 
	·      Your net income before taxes combined with your spouse’s was more than $300,000 in each of the 2 most recent calendar years, and you expect your combined net income before taxes to be more than $300,000 in the current calendar year.	 
	 	 	 

    

     

    

 

	·      Either alone or with your spouse, you own more than $1 million in cash and securities, after subtracting any debt related to the case and securities.	 
	·      Either alone or with your spouse, you may have net assets worth more than $5 million. (Your net assets are your total assets (including real estate) minus your total debt.)	 
	4.       Your name and signature
	By signing this form, you confirm that you have read this form and you understand the risks of making this investment as identified in this form.
	First and last name (please print):
	Signature:	Date: 
	SECTION 5 TO BE COMPLETED BY SALESPERSON
	5.       Salesperson information
	[Instruction: The salesperson is the person who meets with, or provides information to, the purchaser with respect to making this investment. That could include a representative of the issuer or selling security holder, a registrant or a person who is exempt from the registration requirement.]
	First and last name of salesperson (please print):
	Telephone:	Email:
	Name of firm (if registered):
	SECTION 6 TO BE COMPLETED BY THE ISSUER OR SELLING SECURITY HOLDER
	6.       For more information about this investment
	ProMIS Neurosciences Inc.

Kristi Lanier, Finance Director

Tel: [***]

E-mail: [***]

Website: www.promisneurosciences.com

For more information about prospectus exemptions, contact your local securities regulator. You can find contact information at www.securities-administrators.ca

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