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                                                                   EXHIBIT 10.15

                              EMPLOYMENT AGREEMENT
                                (Susan Whoriskey)

         This Employment Agreement dated as of April 10, 2002 (this "Agreement")
is made by and between Mimeon, Inc., a Delaware corporation (the "Company"), and
Susan Whoriskey ("Employee").

         WHEREAS, Employee has been a consultant of the Company since September
25, 2001; and

         WHEREAS, the Company wishes to employ Employee and Employee desires to
be an employee of the Company;

         NOW, THEREFORE, in consideration of the premises and the mutual
covenants and agreements herein contained, the parties hereto agree as follows:

         1.       EMPLOYMENT. The Company hereby employs Employee to perform
those duties and services as the Company shall from time to time set forth, and
Employee accepts employment with the Company, upon the terms and conditions
hereinafter set forth. Employee shall serve as Vice President Licensing and
Business Development of the Company and shall report to the Chief Executive
Officer of the Company. The Chief Executive Officer shall have the right to
review and change the responsibilities of Employee from time to time as he or
she may deem necessary or appropriate provided that such responsibilities are
reasonably consistent with a vice president level position. The Chief Executive
Officer may elect, at his or her discretion, to change the reporting
relationship for Employee.

         2.       DUTY TO PERFORM SERVICES.  Employee shall devote her full time
during normal business hours four days per week to rendering services to the
Company hereunder, and shall exert all reasonable efforts in the rendering of
such services.

         Employee agrees that in the rendering of all services to the Company
and in all aspects of employment hereunder, she shall comply in all material
respects with all directives, policies, standards and regulations from time to
time established by the Company, to the extent they are not in conflict with
this Agreement.

         3.       TERM OF AGREEMENT.  There shall be no definite term of
employment, and Employee shall be an employee at will. The Company may terminate
Employee's employment with the Company at any time with or without Cause (as
defined in Section 17(e) ).

         4.       COMPENSATION.

                  (a)      BASE SALARY. Commencing as of January 1, 2002, and
throughout the term of this Agreement, the Company shall pay Employee a base
salary, payable in equal installments in accordance with the Company's standard
schedule for salary payments to its employees, at an annual rate equal to
$140,000. Employee's base salary shall be reviewed by the Company at least once
every six months, and may be adjusted on or after each such review as mutually
agreed upon by the Company and Employee.

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                  (b)      EQUITY INCENTIVES.

                           (i)      NON-STATUTORY STOCK OPTION.  Pursuant to an
offer letter dated September 18, 2001, from the Company to the Employee, the
Company shall grant to Employee, effective January 1, 2002, a non-statutory
stock option ("NSO") to purchase 2,933 shares of the Company's common stock,
$.0001 par value per share ("Common Stock"), at an exercise price per share
equal to $0.10 per share (which was the fair market value per share on the date
of grant). One half of the shares of Common Stock issuable upon exercise of the
NSO shall be fully vested as of the effective date of the NSO and the balance
shall vest on March 25, 2002.

                           (ii)     RESTRICTED STOCK.  Simultaneous with the
execution of this Agreement, the Company shall sell to Employee 70,477 shares
(the "Shares") of Common Stock at a price per of $0.17 per Share, which is the
current fair market value per share. The purchase and sale of Shares shall be
governed by a Restricted Stock Purchase Agreement, which shall contain, among
other things, a right of the Company to repurchase unvested Shares under certain
circumstances. The Shares shall vest in accordance with the vesting schedule set
forth on SCHEDULE A.

                  (c)      BONUSES.

                           (i)      SIGNING BONUS.  Promptly after the Company
and Employee sign this Agreement, the Company shall pay Employee a signing bonus
of $20,000 in cash.

                           (ii)     YEAR-END BONUS.  If the performance goals
set forth in SCHEDULE B (as the same may be modified from time to time in a
writing signed by the Employee and the Employee's supervisor, the "Performance
Goals") are achieved by December 31, 2002, then the Company shall pay Employee a
bonus of $30,000 in cash by March 1, 2003; PROVIDED, however, that the Company
shall pay Employee a bonus of less than $30,000 if only some of the Performance
Goals have been achieved or if some of the Performance Goals have been partially
achieved; and PROVIDED, further, however, that the amount of the bonus may be
increased by the Chief Executive Officer, after consultation with the
Compensation Committee of the Board of Directors if appropriate, based on other
considerations deemed relevant by the Chief Executive Officer at or about the
time that the bonus is to be awarded. The determination of whether or not a
Performance Goal has been achieved shall be made by the Chief Executive Officer
in his or her sole discretion.

         5.       VACATIONS AND HOLIDAYS; BENEFITS.

                  (a)      VACATION AND HOLIDAYS.  Employee shall be entitled to
15 paid vacation days annually and shall not be required to work but shall be
paid for all major U.S. holidays.

                  (b)      BENEFITS. Employee and, to the extent applicable,
Employee's family, dependents and beneficiaries, shall be entitled to receive
medical and dental insurance coverage through the Company, and such other
benefits, including 401(k) plan, life insurance and disability insurance, as may
be provided by the Company to its other similarly situated senior executives
from time to time (collectively, the "Benefits").

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         6.       EXPENSES.  The Company shall pay or reimburse Employee for all
reasonable business expenses incurred by Employee in connection with her
employment by the Company in accordance with the Company's policies in effect
from time to time.

         7.       CONFIDENTIAL INFORMATION. While employed by the Company and
thereafter, Employee shall not, except as otherwise required pursuant to court
order, directly or indirectly, use any Confidential Information (as defined
below) other than pursuant to her employment by and for the benefit of the
Company, or disclose any Confidential Information to anyone outside of the
Company, whether by private communication, public address, publication or
otherwise, or disclose any Confidential Information to anyone within the Company
who has not been authorized to receive such information, except as directed in
writing by an authorized representative of the Company. The term "Confidential
Information" as used throughout this Agreement shall mean all trade secrets,
proprietary information, and other data or information (and any tangible
evidence, record or representation thereof), whether prepared, conceived or
developed by a consultant or employee of the Company (including Employee) or
received by the Company from an outside source, which is in the possession of
the Company (whether or not the property of the Company), and which is
maintained in confidence by the Company. Without limiting the generality of the
foregoing, Confidential Information shall include:

                  (a)      any idea, improvement, invention, innovation,
development, technical data, design, formula, device, pattern, sequence,
concept, art, method, process, machine, manufacturing method, composition of
matter, computer program or software, source code, object code, algorithm,
model, diagram, flow chart, product specification or design, plan for a new or
revised product, sample, compilation of information, or work in process, and any
and all revisions and improvements relating to any of the foregoing (in each
case whether or not reduced to tangible form); and

                  (b)      the name of any employee, consultant, customer or
prospective customer, any sales plan, marketing material, plan or survey,
business plan or opportunity, product or development plan or specification,
business proposal, financial record, or business record or other record or
information relating to the present or proposed business of the Company.

         Notwithstanding the foregoing, the term Confidential Information shall
not apply to information which the Company has voluntarily disclosed to the
public without restriction, or which has otherwise lawfully entered the public
domain.

         Employee acknowledges that the Company from time to time has in its
possession information which is claimed by customers and others to be
proprietary and which the Company has agreed to keep confidential. Employee
agrees that all such information shall be Confidential Information for purposes
of this Agreement.

         8.       OWNERSHIP AND ASSIGNMENT OF INTELLECTUAL PROPERTY. Employee
agrees that all originals and all copies of materials containing, representing,
evidencing, recording, or constituting any Confidential Information, however and
whenever produced (whether by Employee or others) shall be the sole property of
the Company.

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         Employee agrees that all Confidential Information and all other
discoveries, inventions, ideas, specifications, designs, concepts, research and
other information, processes, products, methods and improvements, or parts
thereof conceived, developed, or otherwise made by him, alone or jointly with
others and in any way relating to the Company's present or proposed products,
programs or services or to tasks assigned to her during the course of her
employment, whether or not patentable or subject to copyright protection and
whether or not reduced to tangible form or reduced to practice, during the
period of her employment with the Company, whether or not made during my regular
working hours, and whether or not made on the Company's premises, and whether or
not disclosed by her to the Company (hereinafter referred to as "Intellectual
Property") together with all products or services which embody or emulate any
Intellectual Property shall belong exclusively to the Company.

         Employee agrees to, and hereby does, assign to the Company all her
right, title and interest throughout the world in and to all Intellectual
Property and to anything tangible which evidences, incorporates, constitutes,
represents or records any Intellectual Property. Employee agrees that all
Intellectual Property shall constitute works made for hire under the copyright
laws of the United States and hereby assigns and, to the extent any such
assignment cannot be made at present, Employee hereby agrees to assign to the
Company all copyrights, patents and other proprietary rights Employee may have
in any Intellectual Property, together with the right to file for and/or own
wholly without restriction United States and foreign patents, trademarks, and
copyrights. Employee agrees to waive, and hereby waives, all moral rights or
proprietary rights in or to any Intellectual Property and, to the extent that
such rights may not be waived, agrees not to assert such rights against the
Company or its licensees, successors or assigns.

         Employee hereby certifies that SCHEDULE C, sets forth any and all
confidential information and intellectual property that Employee claims as her
own or otherwise intends to exclude from this Agreement because it was developed
by her prior to the date of this Agreement. Employee understands that after
execution of this Agreement she shall have no right to exclude Confidential
Information or Intellectual Property from this Agreement.

         9.       EMPLOYEE'S OBLIGATION TO KEEP RECORDS. Employee shall make and
maintain adequate and current written records of all Intellectual Property,
including notebooks and invention disclosures, which records shall be available
to and remain the property of the Company at all times. Employee shall disclose
all Intellectual Property promptly, fully and in writing to the Company
immediately upon production or development of the same and at any time upon
request.

         10.      EMPLOYEE'S OBLIGATION TO COOPERATE. Employee will, at any time
during her employment, or after it terminates, upon request of the Company,
execute all documents and perform all lawful acts which the Company considers
necessary or advisable to secure its rights hereunder and to carry out the
intent of this Agreement. Without limiting the generality of the foregoing,
Employee will assist the Company in any reasonable manner to obtain for its own
benefit patents or copyrights in any and all countries with respect to all
Intellectual Property assigned pursuant to Section 8, and Employee will execute,
when requested, patent and other applications and assignments thereof to the
Company, or Persons (as defined in Section 17(f)) designated by it, and any
other lawful documents deemed necessary by the Company to carry out

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the purposes of this Agreement, and Employee will further assist the Company in
every way to enforce any patents and copyrights obtained, including testifying
in any suit or proceeding involving any of said patents or copyrights or
executing any documents deemed necessary by the Company. It is understood that
(i) reasonable out-of-pocket expenses of Employee's assistance incurred at the
request of the Company under this Section will be reimbursed by the Company, and
(ii) if Employee is required to assist the Company pursuant to this Section at a
time when Employee is no longer an employee of the Company, then the Company
will pay Employee a fee at an hourly rate commensurate with her salary as of the
last day of her employment.

         11.      NONCOMPETITION. Subject to written waivers that maybe provided
by the Company upon request, which shall not be unreasonably withheld, Employee
agrees that during the term of this Agreement and for a period of 12 months
after the termination of this Agreement (the "Restricted Period"), Employee
shall not directly or indirectly (i) provide any services in the Field of
Interest (as defined in Section 17(e)) to any Person other than the Company,
(ii) become an owner, partner, shareholder, consultant, agent, employee or
co-venturer of any Person that has committed, or intends to commit, significant
resources to the Field of Interest.

         12.      NONSOLICITATION. During the Restricted Period, Employee shall
not (i) solicit, encourage, or take any other action which is intended to induce
any employee of, or consultant to, the Company (or any other Person who may have
been employed by, or may have been a consultant to, the Company during the term
of Employee's employment) to terminate his or her employment or relationship
with the Company in order to become employed by or otherwise perform services
for any other Person or (ii) solicit, endeavor to entice away from the Company
or otherwise interfere with the relationship of the Company with any Person who
is, or was within the then-most recent 12 month period, a client or customer of
the Company.

         13.      RETURN OF PROPERTY. Upon termination of Employee's employment
with the Company, or at any other time upon request of the Company, Employee
shall return promptly any Confidential Information, including all customer or
prospective customer lists, other customer or prospective customer information
or related materials, computer programs, software, electronic data,
specifications, drawings, blueprints, medical devices, samples, reproductions,
sketches, notes, notebooks, memoranda, reports, records, proposals, business
plans, or copies of them, other documents or materials, tools, equipment, or
other property belonging to the Company or its customers which Employee may then
possess or have under her control. Employee further agrees that upon termination
of her employment she shall not take with her any documents or data in any form
or of any description containing or pertaining to Confidential Information or
Intellectual Property.

         14.      OTHER OBLIGATIONS.

                  (a)      Employee hereby represents, warrants and agrees (i)
that Employee has the full right to enter into this Agreement and perform the
services required of her hereunder, without any restriction whatsoever; (ii)
that in the course of performing services hereunder, Employee will not violate
the terms or conditions of any agreement between her and any third party or
infringe or wrongfully appropriate any patents, copyrights, trade secrets or
other intellectual property rights of any Person anywhere in the world; (iii)
that Employee has not and

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will not disclose, except as required pursuant to a court order, or use during
her employment by the Company any confidential information that she acquired as
a result of any previous employment or consulting arrangement or under a
previous obligation of confidentiality; and (iv) that Employee has disclosed to
the Company in writing any and all continuing obligations to previous employers
or others that require her not to disclose any information to the Company.

                  (b)      Employee acknowledges that the Company from time to
time may have agreements with other Persons, including the government of the
United States or other countries and agencies thereof, which impose obligations
or restrictions on the Company regarding inventions made during the course of
work thereunder or regarding the confidential nature of such work. Employee
agrees to be bound by all such obligations and restrictions which are made known
to her and to take all action necessary to discharge the obligations of the
Company thereunder.

         15.      TERMINATION EVENT. The following events shall each be
considered a "Termination Event" and, upon the occurrence of any of them, shall
have the effect of immediately terminating the Company's obligations under this
Agreement, including its obligation to make any further payments hereunder but
excluding the payment of base salary and vacation benefits which are accrued at
the date of termination:

                  (a)      Employee's death;

                  (b)      Employee's Disability for such period of time and
under circumstances which would constitute a Long Term Disability;

                  (c)      The termination of Employee's employment by the
Company for Cause (as defined in Section 17(e) ). Termination pursuant to
Section 15(c) shall be without prejudice to any other right or remedy to which
the Company may be entitled, at law, in equity, under this Agreement or
otherwise; or

                  (d)      The termination of Employee's employment by Employee
for any reason.

         Notwithstanding Employee's termination of employment pursuant to
Section 15(b), 15(c) or 15(d), Employee's covenants and obligations set forth in
Sections 7, 8, 10, 11, 12 and 13 shall remain in effect and be fully enforceable
in accordance with the provisions thereof.

         16.      TERMINATION WITHOUT CAUSE.  In addition to the other
termination rights provided to the Company or Employee hereunder, the Company
may terminate Employee's employment without Cause at any time; PROVIDED,
however, that:

                  (a)      Employee's covenants and obligations set forth in
Sections 7, 8, 9, 10, 11, 12 and 13 shall remain in effect and be fully
enforceable in accordance with the provisions thereunder; and

                  (b)      in the event that Employee's employment is terminated
by the Company without Cause at any time after January 1, 2003, Employee shall
be entitled to receive (i) the installments of base salary set forth in Section
4(a) not yet paid to such Employee, payable when

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and as if Employee had continued to be employed by the Company until the three
month anniversary of the date of such termination, and (ii) the benefits set
forth in Section 5(b) for such period of time.

         17.      MISCELLANEOUS.

                  (a)      ENTIRE AGREEMENT. This Agreement constitutes the
entire agreement among the parties with respect to the subject matter hereof and
supersede all other prior agreements and understandings, both written and oral,
between the parties with respect to such subject matter, including the offer
letter dated September 18, 2001, from the Company to Employee.

                  (b)      ASSIGNABILITY, ETC. This Agreement shall be binding
upon and inure to the benefit of the parties hereto and their respective
successors and permitted assigns. This Agreement is not intended to confer upon
any Person other than the parties hereto any rights or remedies hereunder,
except as otherwise expressly provided herein and shall not be assignable by
operation of law or otherwise.

                  (c)      AMENDMENTS AND SUPPLEMENTS.  This Agreement may not
be altered, changed or amended, except by an instrument in writing signed by the
parties hereto.

                  (d)      NO WAIVER. The terms and conditions of this Agreement
may be waived only by a written instrument signed by the party waiving
compliance. In the case of the Company, no waiver shall be effective unless
approved by the Board. The failure of any party hereto to enforce at any time
any of the provisions of this Agreement shall in no way be construed to be a
waiver of any such provision, nor in any way to affect the validity of this
Agreement or any part hereof or the right of such party thereafter to enforce
each and every such provision. No waiver of any breach of or non-compliance with
this Agreement shall be held to be a waiver of any other or subsequent breach or
non-compliance.

                  (e)      CERTAIN DEFINITIONS.  For purposes of this Agreement,
the following terms shall have the meanings set forth below:

                  "Cause" means:

                           (i)      Employee's dishonesty with respect to the
Company;

                           (ii)     Employee's misconduct which materially and
adversely reflects upon the business, affairs, operations, or reputation of the
Company or upon Employee's ability to perform her duties for the Company;

                           (iii)    Employee's failure (except by reason of
Disability) to perform her duties and responsibilities for the Company, which
failure continues for more than ten days after the Company gives written notice
to Employee which sets forth in reasonable detail the nature of such failure;

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                           (iv)     Employee's negligent performance of her
duties, which negligent performance continues for more than ten days after the
Company gives written notice to Employee which sets forth in reasonable detail
the nature of such negligence; or

                           (v)      Employee's breach of any one or more of the
material provisions of this Agreement, which breach continues for more than ten
days after the Company gives written notice to Employee which sets forth in
reasonable detail the nature of such breach.

                  "Disability" means the inability of Employee to substantially
perform her duties to the Company by reason of any medically determinable
physical impairment.

                  "Field of Interest" means the field of sequencing, chemical,
enzymatic or biological synthesis, production or modification of linear and
branched sugars and glycoconjugates.

                  "Long Term Disability" means a Disability which continues for
at least 120 consecutive calendar days or 150 calendar days during any
consecutive twelve-month period, after its commencement, and is determined in
good faith to be total and permanent by the Board following consultation with
reputable medical or health experts selected by the Board.

                  "Person" shall mean an individual, a corporation, an
association, a partnership, an estate, a trust and any other entity or
organization.

                  (f)      CONSTRUCTION OF AGREEMENT. A reference to a Section
or Exhibit shall mean a Section in or Exhibit to this Agreement unless otherwise
expressly stated. The titles and headings herein are for reference purposes only
and shall not in any manner limit the construction of this Agreement which shall
be considered as a whole. The words "include," "includes" and "including" when
used herein shall be deemed in each case to be followed by the words "without
limitation."

                  (g)      NOTICE. All notices and other communications
hereunder shall be in writing and shall be deemed given if delivered by hand,
sent by facsimile transmission with confirmation of receipt, sent via a
reputable overnight courier service with confirmation of receipt requested, or
mailed by registered or certified mail (postage prepaid and return receipt
requested) to the parties at the following addresses (or at such other address
for a party as shall be specified by like notice), and shall be deemed given on
the date on which delivered by hand or otherwise on the date of receipt as
confirmed:

         To the Company:

                  Mimeon, Inc.
                  43 Moulton Street
                  Cambridge, MA 02143
                  Attention:  President
                  Fax:  617.491.9701

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         To Employee:

                  Susan Whoriskey
                  47 Louise Road
                  Belmont, MA 02478

                  (h)      GOVERNING LAW.  This Agreement shall be, governed by,
and construed and enforced in accordance with, the substantive laws of The
Commonwealth of Massachusetts, without regard to its principles of conflicts of
laws.

                  (i)      REMEDIES. Employee recognizes that money damages
alone would not adequately compensate the Company in the event of breach by
Employee of this Agreement, and Employee therefore agrees that, in addition to
all other remedies available to the Company at law, in equity or otherwise, the
Company shall be entitled to injunctive relief for the enforcement hereof. All
rights and remedies hereunder are cumulative and are in addition to and not
exclusive of any other rights and remedies available at law, in equity, by
agreement or otherwise.

                  (j)      SURVIVAL; VALIDITY. Except as expressly provided
herein, the provisions of this Agreement shall not survive termination of
Employee's employment by the Company for any reason. In the event that any
provision of this Agreement shall be determined to be unenforceable by reason of
its extension for too great a period of time or over too large a geographic area
or over too great a range of activities, it shall be interpreted to extend only
over the maximum period of time, geographic area or range of activities as to
which it may be enforceable. If, after application of the preceding sentence,
any provision of this Agreement shall be determined to be invalid, illegal or
otherwise unenforceable by a court of competent jurisdiction, the validity,
legality and enforceability of the other provisions of this Agreement shall not
be affected thereby. Except as otherwise provided in this Section 17, any
invalid, illegal or unenforceable provision of this Agreement shall be
severable, and after any such severance, all other provisions hereof shall
remain in full force and effect.

                  (k)      COUNTERPARTS.  This Agreement may be executed in one
or more counterparts, all of which together shall constitute one and the same
Agreement.

                                    * * * * *

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         IN WITNESS WHEREOF, the parties have caused this Employment Agreement
to be executed as an agreement under seal as of the date first written above.

                                    MIMEON, INC.

                                    By:  /s/ Alan L. Crane
                                       -----------------------------------------
                                       Alan L. Crane
                                       President and Chief Executive Officer

                                         /s/ Susan Whoriskey
                                       -----------------------------------------
                                       Susan Whoriskey

                                       10<Page>

                                                                   EXHIBIT 10.16

                       RESTRICTED STOCK PURCHASE AGREEMENT
                                (Susan Whoriskey)

         This Restricted Stock Purchase Agreement dated as of April 10, 2002
(this "Agreement") is made by and between Mimeon, Inc., a Delaware corporation
(the "Company"), and Susan Whoriskey (the "Purchaser").

         1.       DEFINITIONS.  As used in this Agreement, the following terms
shall have the following meanings:

                  QUALIFIED OFFERING: A firm commitment underwritten public
offering of the Company's Common Stock pursuant to an effective registration
statement under the Securities Act of 1933, as amended (the "Act"), in which the
price per share is at least $10.00 (subject to equitable adjustment in the event
of stock splits and the like) and the aggregate gross proceeds to the Company
from such offering are not less than $15,000,000.

                  QUALIFIED SALE: The sale of all or substantially all of assets
or issued and outstanding capital stock of the Company, or merger or
consolidation involving the Company in which stockholders of the Company
immediately before such merger or consolidation do not own immediately after
such merger or consolidation capital stock or other equity interests of
surviving corporation or entity representing more than fifty percent in voting
power of capital stock or other equity interests of such surviving corporation
or entity outstanding immediately after such merger or consolidation.

                  SERVICE:  Service as an employee, officer or director of, or a
consultant or advisor to, the Company or its successors.

                  SHARES: The shares of Common Stock issued to Purchaser
hereunder and any other securities of the Company which may be issued in
exchange for or in respect of such shares of Common Stock, whether by way of
stock split, stock dividend, combination of shares, reclassification,
recapitalization, reorganization or any other means.

                  UNVESTED SHARES:  Any Shares that are not Vested Shares.

                  VESTED:  Released from the Company's Repurchase Option (as
defined in Section 5(a)).

                  VESTED SHARES:  Any Shares that have vested in accordance with
Section 5(b).

         2.       PURCHASE AND SALE OF SHARES. The Company hereby sells to
Purchaser, and Purchaser hereby purchases from the Company, 70,477 shares of the
Company's common stock, $0.0001 par value per share ("Common Stock"), for a
purchase price per share of $0.17, and an aggregate purchase price of
$11,981.09. The Company acknowledges receipt from Purchaser of $11,981.09 in
cash, in full payment of such purchase price. Purchaser and the Company hereby
agree that the fair market value of the Shares on the date hereof is $0.17 per
share.

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         3.       REPRESENTATIONS OF PURCHASER.  Purchaser understands that the
Shares are not registered under the Act, and represents to the Company, and
agrees that the Company is entitled to rely on such representations, as follows:

                  (a)      Purchaser understands that the Shares have not been
registered under the Act, or registered or qualified under the securities or
"Blue Sky" laws of any jurisdiction, and are being sold pursuant to exemptions
contained in the Act and exemptions contained in other applicable securities or
"Blue Sky" laws. Purchaser understands further that the Company's reliance on
these exemptions is based in part on the representations made by Purchaser in
the Agreement. In this connection, Purchaser represents and warrants that the
offer and sale of the Shares were made solely in Massachusetts.

                  (b)      Purchaser understands the term "accredited investor"
as used in Regulation D promulgated under the Act and represents and warrants to
the Company that she is an "accredited investor" for purposes of acquiring the
Shares. The nature and amount of Purchaser's investment in the Shares is
consistent with Purchaser's investment objectives, abilities, and resources.
Purchaser understands that the Shares are an illiquid investment, which will not
become freely transferable by reason of any "change of circumstances" whatever.
Purchaser has adequate means of providing for Purchaser's current needs and
possible contingencies and has no need for liquidity in Purchaser's investment.

                  (c)      Purchaser is acquiring the Shares for Purchaser's own
account for investment, and not for, with a view to, or in connection with the
resale or distribution thereof. Purchaser has no present intention to sell,
hypothecate, distribute or otherwise transfer the Shares or any portion thereof
or any interest therein.

                  (d)      Purchaser understands that the Shares will constitute
"restricted securities" within the meaning of Rule 144 promulgated under the Act
and that, as such, the Shares must be held indefinitely unless they are
subsequently registered under the Act or unless an exemption from the
registration requirements thereof is available. Purchaser has been advised that
Rule 144, which permits the resale, subject to various terms and conditions, of
small amounts of such "restricted securities" after they have been held for one
year, does not now apply to the Company, because the Company is not now required
to file, and does not file, current reports under the Securities Exchange Act of
1934, and because information concerning the Company substantially equivalent to
that which would be available if the Company were required to file such reports
is not now publicly available. The Company may become a reporting entity at some
future date, but no assurance can be given that it will do so.

                  (e)      In connection with Purchaser's acquisition of the
Shares, Purchaser accepts the condition that the Company may maintain "stop
transfer" orders with respect to the Shares and that each certificate or other
document evidencing the Shares will bear conspicuous legends in substantially
the form set forth in Section 7 of this Agreement.

                  (f)      Purchaser has consulted Purchaser's attorney or
accountant with respect to Purchaser's purchase of the Shares. Purchaser has
fully investigated the Company and its business and financial condition and has
knowledge of the Company's current activities.

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Purchaser acknowledges that the Company has granted Purchaser and Purchaser's
attorney or accountant access to all information about the Company which they
have requested and has offered each of them access to all further information
which they deemed relevant to an investment decision with respect to the Shares.
Purchaser and Purchaser's attorney or accountant have had the opportunity to ask
questions of, and receive answers from, representatives of the Company
concerning such information and the Company's financial condition and prospects.

         4.       RESTRICTIONS ON TRANSFER.  The following restrictions on
transfer of the Shares shall apply:

                  (a)      SECURITIES LAWS. Except for purchases of Unvested
Shares by the Company as contemplated by Section 5, no Shares, nor any interest
therein, may be sold, assigned, pledged or otherwise transferred at any time or
under any circumstances unless (i) the Shares proposed to be transferred have
been registered under the Act and qualified under applicable state securities
laws, or (ii) the Company has received, or agreed to waive, an opinion of
counsel acceptable to the Company to the effect that such transfer may be
effected without registration under the Act or qualification under the
securities laws of relevant states and the proposed transferee has made such
representations and agreements as the Company shall require to assure compliance
with the Act and such laws.

                  (b)      TERMINATION OF REPURCHASE OPTION. Except for
purchases of Unvested Shares by the Company as contemplated by Section 5, no
Shares, nor any interest therein, may be sold, assigned, pledged or otherwise
transferred until the Repurchase Option shall have terminated with respect to
such Shares.

                  (c)      RIGHT OF FIRST OFFER. In the event that at any time
Purchaser desires to sell, assign or otherwise transfer any of the Vested Shares
then held by Purchaser, she shall first offer the Vested Shares desired to be
transferred to the Company by giving written notice of the proposed transfer.
The notice shall state the number of Vested Shares proposed to be transferred,
the name of the person or persons to whom it is proposed to transfer the Vested
Shares, the price at which the Vested Shares are intended to be transferred and
all other terms of the transaction, which must be bona fide. Such notice shall
constitute an offer by Purchaser to the Company for the Company to purchase such
Vested Shares on such terms and at a price per Vested Share equal to the price
stated in the notice. The Company may accept the offer as to all, but not less
than all, of the Vested Shares offered by notifying Purchaser in writing within
30 days after receipt of such notice of its acceptance of the offer. If the
offer is accepted, Purchaser shall sell the offered Vested Shares to the Company
on the terms and at the price per Vested Share as aforesaid, free of all
encumbrances, and shall deliver the certificates representing such Vested
Shares, duly endorsed in blank by Purchaser or with duly executed stock powers
attached thereto, all in form suitable for the transfer of such Vested Shares to
the Company, within 30 days of the date of acceptance of the offer to sell,
against payment therefor at the same price per Vested Share and according to the
same terms as were offered by the proposed transferee. If within the applicable
time period Purchaser does not receive notice of the Company's intention to
purchase the offered Vested Shares, the offer shall be deemed to have been
rejected. In such event, Purchaser may transfer title to the offered Vested
Shares within 90 days from the date of

                                      - 3 -
<Page>

her written notice to the Company of her intention to sell, but such transfer
shall be made only to the proposed transferee or transferees and at the proposed
price and on such other terms as stated in such notice. Vested Shares that are
so transferred to such transferee or transferees shall remain subject to this
Section 3 and as a condition to any transfer Purchaser shall obtain a written
agreement from the transferee by which the transferee agrees to be bound by this
Section 3.

                  (d)      PERMITTED TRANSFERS. Any portion or all of the Vested
Shares may, without compliance with the provisions of Section 4(c), be
transferred by Purchaser to a member of her immediate family or to a family
partnership or family trust, or on Purchaser's death may be transferred to
Purchaser's estate or to those entitled to a distribution of the Vested Shares
under the laws of descent and distribution, provided that Shares that are so
transferred shall remain subject to this Section 4 and as a condition to any
transfer Purchaser shall obtain a written agreement from the transferee by which
the transferee agrees to be bound by this Section 4.

                  (e)      REMEDIES. No sale, assignment, pledge or other
transfer of Shares shall be effective or given effect on the books of the
Company unless all of the applicable provisions of this Section 4 have been duly
complied with. If any transfer of Shares is made or attempted in violation of
the foregoing restrictions, or if Shares are not offered to the Company as
required hereby, the Company shall have the right to purchase such Shares from
the purported owner thereof or her transferee at any time before or after the
transfer, as herein provided. In addition to any other legal or equitable
remedies which it may have, the Company may enforce its rights by actions for
specific performance (to the extent permitted by law) and may refuse to
recognize any transferee as one of its stockholders for any purpose, including,
without limitation, for purposes of dividend and voting rights, until all
applicable provisions hereof have been complied with.

                  (f)      LOCK-UP. Purchaser agrees that for a period of up to
180 days from the effective date of any registration of securities of the
Company (upon request of the Company or the underwriters managing any
underwritten offering of the Company's securities), she will not sell, make any
short sale or loan of, grant any option for the purchase of, or otherwise
dispose of any Shares held by her without the prior written consent of the
Company or such underwriters, as the case may be.

                  (g)      TERMINATION OF RESTRICTIONS.  Sections 4(c) and 4(d)
shall terminate upon the earlier to occur of: (i) immediately prior to the
consummation of a Qualified Sale; or (ii) the closing of a Qualified Offering.

         5.       REPURCHASE OF UNVESTED SHARES.

                  (a)      REPURCHASE OPTION.

                           (i)      In the event of the termination of
Purchaser's Service by Purchaser or the Company for any reason, with or without
cause, the Company shall upon the date of such termination (the "Termination
Date") have an irrevocable, exclusive option (the "Repurchase Option") for a
period of 90 days from such date to repurchase all or any portion of the
Unvested Shares at the repurchase price of $0.17 per share, appropriately
adjusted in the event of a stock

                                      - 4 -
<Page>

dividend, stock split, recapitalization, combination of shares or similar event
occurring subsequent to the date of this Agreement.

                           (ii)     Unless the Company notifies Purchaser within
90 days from the date of termination of Purchaser's Service that it does not
intend to exercise its Repurchase Option with respect to some or all of the
Unvested Shares, the Repurchase Option shall be deemed automatically exercised
by the Company as of the 90th day following such termination, provided that the
Company may notify Purchaser that it is exercising its Repurchase Option as of a
date prior to such 90th day. Unless Purchaser is otherwise notified by the
Company pursuant to the preceding sentence that the Company does not intend to
exercise its Repurchase Option as to some or all of the Unvested Shares to which
it applies at the time of termination, execution of this Agreement by Purchaser
constitutes written notice to Purchaser of the Company's intention to exercise
its Repurchase Option with respect to all Unvested Shares to which such
Repurchase Option applies. The Company, at its choice, may satisfy its payment
obligation to Purchaser with respect to exercise of the Repurchase Option by
either (A) delivering a check to Purchaser in the amount of the purchase price
for the Unvested Shares being repurchased, or (B) in the event Purchaser is
indebted to the Company, canceling an amount of such indebtedness equal to the
purchase price for the Unvested Shares being repurchased, or (C) by a
combination of (A) and (B) so that the combined payment and cancellation of
indebtedness equals such purchase price, provided that the Company shall use
good faith efforts to satisfy its payment obligation to Purchaser within 15 days
after Company's notice of exercise of the Repurchase Option (or deemed
exercise), and that if such check is not delivered or such cancellation is not
effective within such 15 days from such date, the amount of the Company's
unsatisfied payment obligation shall bear interest at a rate of nine percent
(9%) per annum until the Company has satisfied its payment obligation under this
paragraph (ii). In the event of any deemed automatic exercise of the Repurchase
Option pursuant to this Section 5(a)(ii) and Purchaser is then indebted to the
Company, the amount of such indebtedness equal to the purchase price of the
Unvested Shares being repurchased shall be deemed automatically canceled as of
the date of Company's notice of exercise of the Repurchase Option (or deemed
exercise). As a result of any repurchase of Unvested Shares pursuant to this
Section 5(a), the Company shall become the legal and beneficial owner of the
Unvested Shares being repurchased and shall have all rights and interest therein
or related thereto, and the Company shall have the right to transfer to its own
name the number of Unvested Shares being repurchased by the Company, without
further action by Purchaser.

                           (b)      VESTING.  The Shares will become vested in
accordance with the schedule set forth in SCHEDULE A; PROVIDED, however, that
the vesting of Shares on any vesting date shall be conditioned upon Purchaser's
continuing Service with the Company from the date hereof through such vesting
date. Fractional shares shall be rounded down to the nearest whole share.

         6.       CUSTODY OF CERTIFICATES. In order to facilitate the exercise
of the Repurchase Option, the Company or its counsel shall hold all certificates
representing Unvested Shares, together with an adequate number of undated and
otherwise blank stock powers executed by Purchaser. The Company shall have the
right to cause transfers of Unvested Shares to be

                                      - 5 -
<Page>

effected pursuant to Section 5. After any Shares become Vested Shares, the
Company shall, upon request of Purchaser, deliver to Purchaser a certificate or
certificates representing such Vested Shares. After the Company sends Purchaser
a notice that it does not intend to exercise its Repurchase Option as to certain
Unvested Shares, the Company shall, upon request of Purchaser, deliver to
Purchaser a certificate or certificates representing such Unvested Shares.

         7.       LEGENDS.  Each certificate representing Shares shall
prominently bear legends in substantially the following forms:

                  These securities have not been registered under the Securities
                  Act of 1933. They may not be sold, offered for sale, pledged
                  or hypothecated in the absence of a registration statement in
                  effect with respect to the securities under such Act or an
                  opinion of counsel satisfactory to the Corporation that such
                  registration is not required.

                  The securities represented by this certificate have been
                  acquired for investment and have not been registered or
                  qualified under the securities or "Blue Sky" laws of any
                  jurisdiction. They may not be offered or sold without an
                  opinion of counsel to the Corporation to the effect that the
                  proposed transaction will be exempt from registration,
                  qualification, and filings in all applicable jurisdictions.

                  The Corporation is authorized to issue more than one class or
                  series of stock. The powers, designations, preferences and
                  relative participating, optional or other special rights, and
                  the qualifications, limitations or restrictions of such
                  preferences and/or rights of each class of stock or series of
                  any class set forth in the Certificate of Incorporation of the
                  Corporation. The Corporation will furnish a copy of the
                  Certificate of Incorporation of the Corporation to the holder
                  of this certificate without charge upon request.

                  The securities represented by this certificate are subject to
                  restrictions on transfer and repurchase rights pursuant to the
                  terms of a Restricted Stock Purchase Agreement, as amended
                  from time to time, between the owner of this certificate and
                  the Corporation. The Corporation will furnish a copy of this
                  agreement to the holder hereof without charge upon written
                  request.

         8.       MISCELLANEOUS.

                  (a)      ENTIRE AGREEMENT. This Agreement constitutes the
entire agreement between the parties with respect to the subject matter hereof,
and supersedes all prior agreements, negotiations, representations and
proposals, written or oral, relating to such subject matter.

                  (b)      AMENDMENTS.  Neither this Agreement nor any provision
hereof may be changed or modified except by an agreement in writing executed by
Purchaser and on behalf of the Company.

                                      - 6 -
<Page>

                  (c)      BINDING EFFECT OF THE AGREEMENT. This Agreement shall
inure to the benefit of, and be binding upon, the Company, Purchaser and their
respective estates, heirs, executors, transferees, successors, assigns and legal
representatives.

                  (d)      PROVISIONS SEVERABLE. In the event that any provision
of this Agreement shall be determined to be invalid, illegal or otherwise
unenforceable by any court of competent jurisdiction, the validity, legality and
enforceability of the other provisions of this Agreement shall not be affected
thereby. Any invalid, illegal or unenforceable provision of this Agreement shall
be severed, and after any such severance, all other provisions hereof shall
remain in full force and effect.

                  (e)      NOTICES. All notices under this Agreement shall be
effective (i) upon personal or facsimile delivery, (ii) two business days after
deposit in the United States mail as registered or certified mail postage fully
prepaid, or (iii) one business day after pickup by any overnight commercial
courier service, in each case sent or addressed to the Company at its principal
office and to Purchaser at her record address as carried in the stock records of
the Company or at such other address as she may from time to time designate in
writing to the Company.

                  (f)      CONSTRUCTION. A reference to a Section shall mean a
Section of this Agreement unless otherwise expressly stated. The titles and
headings herein are for reference purposes only and shall not in any manner
limit the construction of this Agreement which shall be considered as a whole.
The words "include," "includes" and "including" when used herein shall be deemed
in each case to be followed by the words "without limitation." Whenever the
context may require, any pronouns used herein shall include the corresponding
masculine, feminine or neuter forms, and the singular form of names and pronouns
shall include the plural and vice-versa.

                  (g)      NO EMPLOYMENT AGREEMENT.  This Agreement shall not be
construed as an agreement by the Company to employ Purchaser, nor is the Company
obligated to employ Purchaser by reason of this Agreement or the issuance of the
Shares to Purchaser.

                  (h)      SECTION 83(b) ELECTION. Purchaser will furnish to the
Company a copy of any election made by Purchaser under Section 83(b) of the
Internal Revenue Code of 1986, as amended, with respect to her acquisition of
the Shares.

                  (i)      APPLICABLE LAW. This Agreement shall be construed and
enforced in accordance with the laws of The Commonwealth of Massachusetts,
without regard to its principles of conflicts of laws. Purchaser consents to
jurisdiction and venue in any state or federal court in The Commonwealth of
Massachusetts for the purposes of any action relating to or arising out of this
Agreement or any breach or alleged breach hereof, and to service of process in
any such action by certified or registered mail, return receipt requested.

                  (j)      DISPOSITION OF SHARES; PURCHASE BY NOMINEE OR
DESIGNEE. Any Shares that the Company elects to purchase hereunder may be
disposed of by it in such manner as it deems appropriate with or without
restrictions on the transfer thereof, and the Company may

                                      - 7 -
<Page>

require their transfer to a nominee or designee as part of any purchase of the
Shares from Purchaser.

                  (k)      WITHHOLDING TAXES. Purchaser acknowledges and agrees
that the Company has the right to deduct from payments of any kind otherwise due
to Purchaser any federal, state or local taxes of any kind required by law to be
withheld with respect to the purchase of the Shares by Purchaser.

         IN WITNESS WHEREOF, the parties hereto have executed this Restricted
Stock Purchase Agreement as of the date first above written.

                                    MIMEON, INC.

                                    By: /s/ Alan Crane
                                        ----------------------------------------
                                    Name:  Alan Crane
                                    Title: Chairman and CEO

                                    /s/ Susan Whoriskey
                                    --------------------------------------------
                                    Susan Whoriskey

                                      - 8 -
<Page>

                                   Schedule A

                                Vesting Schedule

<Table>
<Caption>
                                                             Number of Shares that First
                                                             ---------------------------
                      Vesting Date                          Become Vested on Vesting Date
                      ------------                          -----------------------------
            <S>                                                          <C>
            January 1, 2002                                               1,542

            April 1, 2002                                                 1,542

            July 1, 2002                                                  1,542

            October 1, 2002                                               1,542

            January 1, 2003                                              12,994

            The first day of each fiscal quarter                          4,405
            starting April 1, 2003 and ending
            October 1, 2005:

            January 1, 2006                                               4,402
                                                                         ------

                 Totals:                                                 70,477
</Table>

                                      - 9 -

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