Document:

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                                                                     EXHIBIT 4.3

                                  QUOVADX, INC.

                            1999 DIRECTOR OPTION PLAN
      (AS AMENDED AND RESTATED EFFECTIVE NOVEMBER 19, 2001, FORMERLY TITLED
                THE "XCARE.NET, INC. 1999 DIRECTOR OPTION PLAN")

     1. Purposes of the Plan. The purposes of this 1999 Director Option Plan are
to attract and retain the best available personnel for service as Outside
Directors (as defined herein) of the Company, to provide additional incentive to
the Outside Directors of the Company to serve as Directors, and to encourage
their continued service on the Board.

          All options granted hereunder shall be nonstatutory stock options.

     2. Definitions. As used herein, the following definitions shall apply:

          (a) "Board" means the Board of Directors of the Company.

          (b) "Code" means the Internal Revenue Code of 1986, as amended.

          (c) "Common Stock" means the common stock of the Company.

          (d) "Company" means Quovadx, Inc., a Delaware corporation.

          (e) "Director" means a member of the Board.

          (f) "Disability" means total and permanent disability as defined in
     section 22(e)(3) of the Code.

          (g) "Employee" means any person, including officers and Directors,
     employed by the Company or any Parent or Subsidiary of the Company. The
     payment of a Director's fee by the Company shall not be sufficient in and
     of itself to constitute "employment" by the Company.

          (h) "Exchange Act" means the Securities Exchange Act of 1934, as
     amended.

          (i) "Fair Market Value" means, as of any date, the value of Common
     Stock determined as follows:

               (i) If the Common Stock is listed on any established stock
          exchange or a national market system, including without limitation the
          Nasdaq National Market or The Nasdaq SmallCap Market of The Nasdaq
          Stock Market, its Fair Market Value shall be the closing sales price
          for such stock (or the closing bid, if no sales were reported) as
          quoted on such exchange or system for the last market trading day
          prior to the time of grant as reported in The Wall Street Journal or
          such other source as the Administrator deems reliable;

               (ii) If the Common Stock is regularly quoted by a recognized
          securities dealer but selling prices are not reported, the Fair Market
          Value of a Share of Common Stock shall

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          be the mean between the high bid and low asked prices for the Common
          Stock for the last market trading day prior to the time of grant, as
          reported in The Wall Street Journal or such other source as the Board
          deems reliable; or

               (iii) In the absence of an established market for the Common
          Stock, the Fair Market Value thereof shall be determined in good faith
          by the Board.

          (j) "Inside Director" means a Director who is an Employee.

          (k) "IPO Effective Date" means the date upon with the Securities and
     Exchange Commission declares the initial public offering of the Company's
     common stock as effective.

          (l) "Option" means a stock option granted pursuant to the Plan.

          (m) "Optioned Stock" means the Common Stock subject to an Option.

          (n) "Optionee" means a Director who holds an Option.

          (o) "Outside Director" means a Director who is not an Employee.

          (p) "Parent" means a "parent corporation," whether now or hereafter
     existing, as defined in Section 424(e) of the Code.

          (q) "Plan" means this 1999 Director Option Plan.

          (r) "Share" means a share of the Common Stock, as adjusted in
     accordance with Section 10 of the Plan.

          (s) "Subsidiary" means a "subsidiary corporation," whether now or
     hereafter existing, as defined in Section 424(f) of the Internal Revenue
     Code of 1986.

     3. Stock Subject to the Plan. Subject to the provisions of Section 10 of
the Plan, the maximum aggregate number of Shares which may be optioned and sold
under the Plan is 250,000 Shares (the "Pool"), plus an annual increase to be
added on January 1 of each year, beginning in 2001, equal to the lesser of (i)
200,000 shares, (ii) 1% of the outstanding shares on such date, or (iii) a
lesser amount determined by the Board. The Shares may be authorized, but
unissued, or reacquired Common Stock.

     If an Option expires or becomes unexercisable without having been exercised
in full, the unpurchased Shares which were subject thereto shall become
available for future grant or sale under the Plan (unless the Plan has
terminated). Shares that have actually been issued under the Plan shall not be
returned to the Plan and shall not become available for future distribution
under the Plan.

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     4. Administration and Grants of Options under the Plan.

          (a) Procedure for Grants. All grants of Options to Outside Directors
     under this Plan shall be automatic and nondiscretionary and shall be made
     strictly in accordance with the following provisions:

                (i) No person shall have any discretion to select which Outside
          Directors shall be granted Options or to determine the number of
          Shares to be covered by Options.

               (ii) Each Outside Director shall be automatically granted an
          Option to purchase 25,000 Shares (the "First Option") on the date on
          which the later of the following events occurs: (A) the IPO Effective
          Date, or (B) the date on which such person first becomes an Outside
          Director, whether through election by the shareholders of the Company
          or appointment by the Board to fill a vacancy; provided, however, that
          an Inside Director who ceases to be an Inside Director but who remains
          a Director shall not receive a First Option.

               (iii) Each Outside Director shall be automatically granted an
          Option to purchase 10,000 Shares (a "Subsequent Option") on the date
          of the annual stockholders meeting of each year provided he or she is
          then an Outside Director and if as of such date, he or she shall have
          served on the Board for at least the preceding six (6) months.

                (iv) Notwithstanding the provisions of subsections (ii) and
          (iii) hereof, any exercise of an Option granted before the Company has
          obtained shareholder approval of the Plan in accordance with Section
          16 hereof shall be conditioned upon obtaining such shareholder
          approval of the Plan in accordance with Section 16 hereof.

                 (v) The terms of a First Option granted hereunder shall be as
          follows:

                     (A) the term of the First Option shall be ten (10) years.

                     (B) the First Option shall be exercisable only while the
               Outside Director remains a Director of the Company, except as set
               forth in Sections 8 and 10 hereof.

                     (C) the exercise price per Share shall be 100% of the Fair
               Market Value per Share on the date of grant of the First Option.

                     (D) subject to Section 10 hereof, the First Option shall
               become exercisable as to 25% percent of the Shares subject to the
               First Option on each anniversary of its date of grant, provided
               that the Optionee continues to serve as a Director on such dates.

                (vi) The terms of a Subsequent Option granted hereunder shall be
          as follows:

                     (A) the term of the Subsequent Option shall be ten (10)
               years.

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                    (B) the Subsequent Option shall be exercisable only while
               the Outside Director remains a Director of the Company, except as
               set forth in Sections 8 and 10 hereof

                    (C) the exercise price per Share shall be 100% of the Fair
               Market Value per Share on the date of grant of the Subsequent
               Option.

                    (D) subject to Section 10 hereof, the Subsequent Option
               shall become exercisable as to 100% percent of the Shares subject
               to the Subsequent Option on the anniversary of its date of grant,
               provided that the Optionee continues to serve as a Director on
               such date.

               (vii) In the event that any Option granted under the Plan would
          cause the number of Shares subject to outstanding Options plus the
          number of Shares previously purchased under Options to exceed the
          Pool, then the remaining Shares available for Option grant shall be
          granted under Options to the Outside Directors on a pro rata basis. No
          further grants shall be made until such time, if any, as additional
          Shares become available for grant under the Plan through action of the
          Board or the shareholders to increase the number of Shares which may
          be issued under the Plan or through cancellation or expiration of
          Options previously granted hereunder.

     5. Eligibility. Options may be granted only to Outside Directors. All
Options shall be automatically granted in accordance with the terms set forth in
Section 4 hereof.

     The Plan shall not confer upon any Optionee any right with respect to
continuation of service as a Director or nomination to serve as a Director, nor
shall it interfere in any way with any rights which the Director or the Company
may have to terminate the Director's relationship with the Company at any time.

     6. Term of Plan. The Plan shall become effective upon the earlier to occur
of its adoption by the Board or its approval by the shareholders of the Company
as described in Section 16 of the Plan. It shall continue in effect for a term
of ten (10) years unless sooner terminated under Section 11 of the Plan.

     7. Form of Consideration. The consideration to be paid for the Shares to be
issued upon exercise of an Option, including the method of payment, shall
consist of (i) cash, (ii) check, (iii) other shares which (x) in the case of
Shares acquired upon exercise of an option, have been owned by the Optionee for
more than six (6) months on the date of surrender, and (y) have a Fair Market
Value on the date of surrender equal to the aggregate exercise price of the
Shares as to which said Option shall be exercised, (iv) consideration received
by the Company under a cashless exercise program implemented by the Company in
connection with the Plan, or (v) any combination of the foregoing methods of
payment.

     8. Exercise of Option.

          (a) Procedure for Exercise; Rights as a Shareholder. Any Option
     granted hereunder shall be exercisable at such times as are set forth in
     Section 4 hereof; provided, however, that no Options shall be exercisable
     until shareholder approval of the Plan in accordance with Section 16 hereof
     has been obtained.

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          An Option may not be exercised for a fraction of a Share.

          An Option shall be deemed to be exercised when written notice of such
     exercise has been given to the Company in accordance with the terms of the
     Option by the person entitled to exercise the Option and full payment for
     the Shares with respect to which the Option is exercised has been received
     by the Company. Full payment may consist of any consideration and method of
     payment allowable under Section 7 of the Plan. Until the issuance (as
     evidenced by the appropriate entry on the books of the Company or of a duly
     authorized transfer agent of the Company) of the stock certificate
     evidencing such Shares, no right to vote or receive dividends or any other
     rights as a shareholder shall exist with respect to the Optioned Stock,
     notwithstanding the exercise of the Option. A share certificate for the
     number of Shares so acquired shall be issued to the Optionee as soon as
     practicable after exercise of the Option. No adjustment shall be made for a
     dividend or other right for which the record date is prior to the date the
     stock certificate is issued, except as provided in Section 10 of the Plan.

          Exercise of an Option in any manner shall result in a decrease in the
     number of Shares which thereafter may be available, both for purposes of
     the Plan and for sale under the Option, by the number of Shares as to which
     the Option is exercised.

          (b) Termination of Continuous Status as a Director. Subject to Section
     10 hereof, in the event an Optionee's status as a Director terminates
     (other than upon the Optionee's death or Disability), the Optionee may
     exercise his or her Option, but only within three (3) months following the
     date of such termination, and only to the extent that the Optionee was
     entitled to exercise it on the date of such termination (but in no event
     later than the expiration of its ten (10) year term). To the extent that
     the Optionee was not entitled to exercise an Option on the date of such
     termination, and to the extent that the Optionee does not exercise such
     Option (to the extent otherwise so entitled) within the time specified
     herein, the Option shall terminate.

          (c) Disability of Optionee. In the event Optionee's status as a
     Director terminates as a result of Disability, the Optionee may exercise
     his or her Option, but only within twelve (12) months following the date of
     such termination, and only to the extent that the Optionee was entitled to
     exercise it on the date of such termination (but in no event later than the
     expiration of its ten (10) year term). To the extent that the Optionee was
     not entitled to exercise an Option on the date of termination, or if he or
     she does not exercise such Option (to the extent otherwise so entitled)
     within the time specified herein, the Option shall terminate.

          (d) Death of Optionee. In the event of an Optionee's death, the
     Optionee's estate or a person who acquired the right to exercise the Option
     by bequest or inheritance may exercise the Option, but only within twelve
     (12) months following the date of death, and only to the extent that the
     Optionee was entitled to exercise it on the date of death (but in no event
     later than the expiration of its ten (10) year term). To the extent that
     the Optionee was not entitled to exercise an Option on the date of death,
     and to the extent that the Optionee's estate or a person who acquired the
     right to exercise such Option does not exercise such Option (to the extent
     otherwise so entitled) within the time specified herein, the Option shall
     terminate.

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     9. Non-Transferability of Options. Except as provided in this Section 9,
the Option may not be sold, pledged, assigned, hypothecated, transferred, or
disposed of in any manner other than by will or by the laws of descent or
distribution. Notwithstanding the foregoing, the Company may, in its sole
discretion and by its prior written consent, permit the transfer of an Option by
an Optionee to

          (a) A member of such Optionee's immediate family;

          (b) A trust or estate in which the Optionee and any of the persons
     listed in paragraph 9(a) of this section collectively own 100% of the
     beneficial interest; or

          (c) An entity over which the Optionee exercises authority that is
     sufficient, in the determination of the Company, to direct the voting and
     disposition of securities held by such entity.

     10. Adjustments Upon Changes in Capitalization, Dissolution, Merger or
Asset Sale.

          (a) Changes in Capitalization. Subject to any required action by the
     shareholders of the Company, the number of Shares covered by each
     outstanding Option, the number of Shares which have been authorized for
     issuance under the Plan but as to which no Options have yet been granted or
     which have been returned to the Plan upon cancellation or expiration of an
     Option, as well as the price per Share covered by each such outstanding
     Option, and the number of Shares issuable pursuant to the automatic grant
     provisions of Section 4 hereof shall be proportionately adjusted for any
     increase or decrease in the number of issued Shares resulting from a stock
     split, reverse stock split, stock dividend, combination or reclassification
     of the Common Stock, or any other increase or decrease in the number of
     issued Shares effected without receipt of consideration by the Company;
     provided, however, that conversion of any convertible securities of the
     Company shall not be deemed to have been "effected without receipt of
     consideration." Except as expressly provided herein, no issuance by the
     Company of shares of stock of any class, or securities convertible into
     shares of stock of any class, shall affect, and no adjustment by reason
     thereof shall be made with respect to, the number or price of Shares
     subject to an Option.

          (b) Dissolution or Liquidation. In the event of the proposed
     dissolution or liquidation of the Company, to the extent that an Option has
     not been previously exercised, it shall terminate immediately prior to the
     consummation of such proposed action.

          (c) Merger or Asset Sale. In the event of a merger of the Company with
     or into another corporation or the sale of substantially all of the assets
     of the Company, outstanding Options may be assumed or equivalent options
     may be substituted by the successor corporation or a Parent or Subsidiary
     thereof (the "Successor Corporation"). If an Option is assumed or
     substituted for, the Option or equivalent option shall continue to be
     exercisable as provided in Section 4 hereof for so long as the Optionee
     serves as a Director or a director of the Successor Corporation. Following
     such assumption or substitution, if the Optionee's status as a Director or
     director of the Successor Corporation, as applicable, is terminated other
     than upon a voluntary resignation by the Optionee, the Option or option
     shall become fully exercisable, including as to Shares for which it would
     not otherwise be exercisable. Thereafter, the Option or option shall remain
     exercisable in accordance with Sections 8(b) through (d) above.

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     If the Successor Corporation does not assume an outstanding Option or
substitute for it an equivalent option, the Option shall become fully vested and
exercisable, including as to Shares for which it would not otherwise be
exercisable. In such event the Board shall notify the Optionee that the Option
shall be fully exercisable for a period of thirty (30) days from the date of
such notice, and upon the expiration of such period the Option shall terminate.

     For the purposes of this Section 10(c), an Option shall be considered
assumed if, following the merger or sale of assets, the Option confers the right
to purchase or receive, for each Share of Optioned Stock subject to the Option
immediately prior to the merger or sale of assets, the consideration (whether
stock, cash, or other securities or property) received in the merger or sale of
assets by holders of Common Stock for each Share held on the effective date of
the transaction (and if holders were offered a choice of consideration, the type
of consideration chosen by the holders of a majority of the outstanding Shares).
If such consideration received in the merger or sale of assets is not solely
common stock of the successor corporation or its Parent, the Administrator may,
with the consent of the successor corporation, provide for the consideration to
be received upon the exercise of the Option, for each Share of Optioned Stock
subject to the Option, to be solely common stock of the successor corporation or
its Parent equal in fair market value to the per share consideration received by
holders of Common Stock in the merger or sale of assets.

     11. Amendment and Termination of the Plan.

          (a) Amendment and Termination. The Board may at any time amend, alter,
     suspend, or discontinue the Plan, but no amendment, alteration, suspension,
     or discontinuation shall be made which would impair the rights of any
     Optionee under any grant theretofore made, without his or her consent. In
     addition, to the extent necessary and desirable to comply with any
     applicable law, regulation or stock exchange rule, the Company shall obtain
     shareholder approval of any Plan amendment in such a manner and to such a
     degree as required.

          (b) Effect of Amendment or Termination. Any such amendment or
     termination of the Plan shall not affect Options already granted and such
     Options shall remain in full force and effect as if this Plan had not been
     amended or terminated.

     12. Time of Granting Options. The date of grant of an Option shall, for all
purposes, be the date determined in accordance with Section 4 hereof.

     13. Conditions Upon Issuance of Shares. Shares shall not be issued pursuant
to the exercise of an Option unless the exercise of such Option and the issuance
and delivery of such Shares pursuant thereto shall comply with all relevant
provisions of law, including, without limitation, the Securities Act of 1933, as
amended, the Exchange Act, the rules and regulations promulgated thereunder,
state securities laws, and the requirements of any stock exchange upon which the
Shares may then be listed, and shall be further subject to the approval of
counsel for the Company with respect to such compliance.

     As a condition to the exercise of an Option, the Company may require the
person exercising such Option to represent and warrant at the time of any such
exercise that the Shares are

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being purchased only for investment and without any present intention to sell or
distribute such Shares, if, in the opinion of counsel for the Company, such a
representation is required by any of the aforementioned relevant provisions of
law.

     Inability of the Company to obtain authority from any regulatory body
having jurisdiction, which authority is deemed by the Company's counsel to be
necessary to the lawful issuance and sale of any Shares hereunder, shall relieve
the Company of any liability in respect of the failure to issue or sell such
Shares as to which such requisite authority shall not have been obtained.

     14. Reservation of Shares. The Company, during the term of this Plan, will
at all times reserve and keep available such number of Shares as shall be
sufficient to satisfy the requirements of the Plan.

     15. Option Agreement. Options shall be evidenced by written option
agreements in such form as the Board shall approve.

     16. Shareholder Approval. The Plan was approved by the Company's
shareholders in December, 1999. Additional shareholder approval shall be
obtained in the degree and manner required under applicable state and federal
law and any stock exchange rules.

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                                    EXHIBIT A

                            1999 DIRECTOR OPTION PLAN

                                 EXERCISE NOTICE

QUOVADX, INC.6400 S. Fiddler's Green Circle
Suite 1000
Englewood, CO  80111
Attention: General Counsel

     1. Exercise of Option. The undersigned ("Optionee") hereby elects to
exercise Optionee's option to purchase ______ shares of the Common Stock (the
"Shares") of Quovadx, Inc. (the "Company") under and pursuant to the Company's
1999 Director Option Plan and the Option Agreement dated _______________ (the
"Agreement").

     2. Representations of Optionee. Optionee acknowledges that Optionee has
received, read and understood the Agreement.

     3. Federal Restrictions on Transfer. Optionee understands that the Shares
must be held indefinitely unless they are registered under the Securities Act of
1933, as amended (the "1933 Act"), or unless an exemption from such registration
is available, and that the certificate(s) representing the Shares may bear a
legend to that effect. Optionee understands that the Company is under no
obligation to register the Shares and that an exemption may not be available or
may not permit Optionee to transfer Shares in the amounts or at the times
proposed by Optionee.

     4. Tax Consequences. Optionee understands that Optionee may suffer adverse
tax consequences as a result of Optionee's purchase or disposition of the
Shares. Optionee represents that Optionee has consulted with any tax
consultant(s) Optionee deems advisable in connection with the purchase or
disposition of the Shares and that Optionee is not relying on the Company for
any tax advice.

     5. Delivery of Payment. Optionee herewith delivers to the Company the
aggregate purchase price for the Shares that Optionee has elected to purchase
and has made provision for the payment of any federal or state withholding taxes
required to be paid or withheld by the Company.

     6. Entire Agreement. The Agreement is incorporated herein by reference.
This Exercise Notice and the Agreement constitute the entire agreement of the
parties and supersede

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in their entirety all prior undertakings and agreements of the Company and
Optionee with respect to the subject matter hereof. This Exercise Notice and the
Agreement are governed by California law except for that body of law pertaining
to conflict of laws.

Submitted by:                              Accepted by:

OPTIONEE:                                  QUOVADX, INC.

By:                                        By:
    --------------------------------            --------------------------------

                                           Its:
------------------------------------            --------------------------------
                                                Print Name
Address:

Dated:                                     Date Received:
      ------------------------------                      ----------------------

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                                  ATTACHMENT 1

                                       TO

           NOTICE OF GRANT OF STOCK OPTIONS 1999 DIRECTOR OPTION PLAN
                              AND OPTION AGREEMENT

                                - FIRST OPTION -

     1. Grant of Option. Quovadx, Inc., (the "Company"), has granted to the
Optionee named in the Notice of Grant (the "Optionee"), an option to purchase
the number of shares of the Company's Common Stock as set forth in the Notice of
Grant (the "Optioned Stock"), at the price per share as set forth in the Notice
of Grant, and in all respects subject to the terms, definitions and provisions
of the Company's 1999 Director Option Plan (the "Plan") adopted by the Company
and as amended from time to time which is incorporated herein by reference. The
terms defined in the Plan shall have the same defined meanings herein.

     2. Nature of the Option. This First Option is a nonstatutory option and is
not intended to qualify for any special tax benefits to the Optionee.

     3. Exercise of Option. This First Option shall be exercisable during its
term in accordance with the provisions of Sections 4 and 8 of the Plan as
follows:

          (i) Right to Exercise.

               (a) This First Option shall become exercisable cumulatively as to
          25% of the Optioned Stock subject to this First Option on each
          anniversary of its date of grant; provided that in no event shall any
          Option be exercisable prior to the date the stockholders of the
          Company approve the Plan and provided that Optionee continues to serve
          as a Director of the Company on such date, except as set forth in
          Sections 8 and 10 of the Plan.

               (b) This Option may not be exercised for a fraction of a share.

               (c) In the event of Optionee's death, disability or other
          termination of service as a Director, the exercisability of the Option
          is governed by Sections 8 and 10 of the Plan.

          (ii) Method of Exercise. This Option shall be exercisable by the
     delivery of a written exercise notice which shall state the election to
     exercise the Option and the number of Shares in respect of which the Option
     is being exercised. Such written notice, in the form attached hereto as
     Exhibit A (the Exercise Notice), shall be signed by the Optionee and shall
     be delivered in person or by certified mail to the General Counsel of the
     Company. The Exercise Notice shall be accompanied by full payment of the
     exercise price.

     4. Method of Payment. Payment of the exercise price shall be by any of the
following, or a combination thereof, at the election of the Optionee:

     (i)  cash;

                                        2

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     (ii) check;

     (iii) surrender of other Shares, provided Shares acquired from the Company,
          (x) have been owned by the Optionee for more than six (6) months on
          the date of surrender, and (y) have a Fair Market Value on the date of
          surrender equal to the aggregate exercise price of the Shares as to
          which said Option shall be exercised; or

     (iv) delivery of a properly executed exercise notice together with such
          other documentation as the Company and the broker, if applicable,
          shall require to effect an exercise of the Option and delivery to the
          Company of the sale proceeds required to pay the exercise price.

     5. Restriction on Exercise. This Option may not be exercised if the
issuance of such Shares upon such exercise or the method of payment of
consideration for such shares would constitute a violation of any applicable
federal or state securities or other law or regulations, or if such issuance
would not comply with the requirements of any stock exchange upon which the
Shares may then be listed. As a condition to the exercise of this Option, the
Company may require Optionee to make any representation and warranty to the
Company as may be required by any applicable law or regulation.

     6. Non-Transferability of Option. Except as provided in Section 9 of the
Plan, the Option may not be transferred in any manner otherwise than by will or
by the laws of descent or distribution Notwithstanding the foregoing, the
Company may, in its sole discretion and by its prior written consent, permit the
transfer of an Option by an Optionee to:

          (a) A member of such Optionee's immediate family;

          (b) A trust or estate in which the Optionee and any of the persons
     listed in paragraph 6(a) of this section collectively own 100% of the
     beneficial interest; or

          (c) An entity over which the Optionee exercises authority that is
     sufficient, in the determination of the Company, to direct the voting and
     disposition of securities held by such entity.

     7. Term of Option. This Option may not be exercised more than ten (10)
years from the date of grant of this Option, and may be exercised during such
period only in accordance with the Plan and the terms of this Option.

     8. Taxation Upon Exercise of Option. Optionee understands that, upon
exercise of this Option, he or she will recognize income for tax purposes in an
amount equal to the excess of the then Fair Market Value of the Shares purchased
over the exercise price paid for such Shares. Since the Optionee is subject to
Section 16(b) of the Securities Exchange Act of 1934, as amended, under certain
limited circumstances the measurement and timing of such income (and the
commencement of any capital gain holding period) may be deferred, and the
Optionee is advised to contact a tax advisor concerning the application of
Section 83 in general and the availability a Section 83(b) election in
particular in connection with the exercise of the Option. Upon a resale of such
Shares by the Optionee, any difference between the sale price and the Fair

                                        3

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Market Value of the Shares on the date of exercise of the Option, to the extent
not included in income as described above, will be treated as capital gain or
loss.

     Optionee acknowledges receipt of a copy of the Plan, a copy of which is
attached hereto, and represents that he or she is familiar with the terms and
provisions thereof, and hereby accepts this Option subject to all of the terms
and provisions thereof. Optionee hereby agrees to accept as binding, conclusive
and final all decisions or interpretations of the Board upon any questions
arising under the Plan.

                                       4

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                                  ATTACHMENT 1

                                       TO

              NOTICE OF GRANT OF STOCK OPTIONS AND OPTION AGREEMENT

                              - SUBSEQUENT OPTION -

1. Grant of Option. Quovadx, Inc., (the "Company"), has granted to the Optionee
named in the Notice of Grant (the "Optionee"), an option to purchase the number
of shares of the Company's Common Stock as set forth in the Notice of Grant (the
"Optioned Stock"), at the price per share as set forth in the Notice of Grant,
and in all respects subject to the terms, definitions and provisions of the
Company's 1999 Director Option Plan (the "Plan") adopted by the Company and as
amended from time to time which is incorporated herein by reference. The terms
defined in the Plan shall have the same defined meanings herein.

2. Nature of the Option. This Subsequent Option is a nonstatutory option and is
not intended to qualify for any special tax benefits to the Optionee.

3. Exercise of Option. This Subsequent Option shall be exercisable during its
term in accordance with the provisions of Sections 8 and 10 of the Plan as
follows:

     (i) Right to Exercise.

          (a) This Subsequent Option shall become exercisable as to 100% of the
     Optioned Stock subject to this Subsequent Option on the anniversary of its
     date of grant,; provided that in no event shall any Option be exercisable
     prior to the date the stockholders of the Company approve the Plan and
     provided that Optionee continues to serve as a Director on such date,
     except as set forth in Sections 8 and 10 of the Plan.

          (b) This Option may not be exercised for a fraction of a share.

          (c) In the event of Optionee's death, disability or other termination
     of service as a Director, the exercisability of the Option is governed by
     Sections 8 and 10 of the Plan.

     (ii) Method of Exercise. This Option shall be exercisable by the delivery
of a written exercise notice which shall state the election to exercise the
Option and the number of Shares in respect of which the Option is being
exercised. Such written notice, in the form attached hereto as Exhibit A (the
Exercise Notice), shall be signed by the Optionee and shall be delivered in
person or by certified mail to the General Counsel of the Company. The Exercise
Notice shall be accompanied by full payment of the exercise price.

4. Method of Payment. Payment of the exercise price shall be by any of the
following, or a combination thereof, at the election of the Optionee:

     (i)  cash;

                                        2

<PAGE>

     (ii) check;

     (iii) surrender of other Shares, provided Shares acquired from the Company,
          (x) have been owned by the Optionee for more than six (6) months on
          the date of surrender, and (y) have a Fair Market Value on the date of
          surrender equal to the aggregate exercise price of the Shares as to
          which said Option shall be exercised; or

     (iv) delivery of a properly executed exercise notice together with such
          other documentation as the Company and the broker, if applicable,
          shall require to effect an exercise of the Option and delivery to the
          Company of the sale proceeds required to pay the exercise price.

5. Restriction on Exercise. This Option may not be exercised if the issuance of
such Shares upon such exercise or the method of payment of consideration for
such shares would constitute a violation of any applicable federal or state
securities or other law or regulations, or if such issuance would not comply
with the requirements of any stock exchange upon which the Shares may then be
listed. As a condition to the exercise of this Option, the Company may require
Optionee to make any representation and warranty to the Company as may be
required by any applicable law or regulation.

6. Non-Transferability of Option. Except as provided in Section 9 of the Plan,
this Subsequent Option may not be transferred in any manner otherwise than by
will or by the laws of descent or distribution Notwithstanding the foregoing,
the Company may, in its sole discretion and by its prior written consent, permit
the transfer of an Option by an Optionee to:

     (a) A member of such Optionee's immediate family;

     (b) A trust or estate in which the Optionee and any of the persons listed
in paragraph 6(a) of this section collectively own 100% of the beneficial
interest; or

     (c) An entity over which the Optionee exercises authority that is
sufficient, in the determination of the Company, to direct the voting and
disposition of securities held by such entity.

7. Term of Option. This Option may not be exercised more than ten (10) years
from the date of grant of this Option, and may be exercised during such period
only in accordance with the Plan and the terms of this Option.

8. Taxation Upon Exercise of Option. Optionee understands that, upon exercise of
this Option, he or she will recognize income for tax purposes in an amount equal
to the excess of the then Fair Market Value of the Shares purchased over the
exercise price paid for such Shares. Since the Optionee is subject to Section
16(b) of the Securities Exchange Act of 1934, as amended, under certain limited
circumstances the measurement and timing of such income (and the commencement of
any capital gain holding period) may be deferred, and the Optionee is advised to
contact a tax advisor concerning the application of Section 83 in general and
the availability a Section 83(b) election in particular in connection with the
exercise of the Option. Upon a resale of such Shares by

                                        3

<PAGE>

the Optionee, any difference between the sale price and the Fair Market Value of
the Shares on the date of exercise of the Option, to the extent not included in
income as described above, will be treated as capital gain or loss.

     Optionee acknowledges receipt of a copy of the Plan, a copy of which is
attached hereto, and represents that he or she is familiar with the terms and
provisions thereof, and hereby accepts this Option subject to all of the terms
and provisions thereof. Optionee hereby agrees to accept as binding, conclusive
and final all decisions or interpretations of the Board upon any questions
arising under the Plan.

                                       4<PAGE>

                                                                     EXHIBIT 4.4

                                  QUOVADX, INC.

                       2000 NONSTATUTORY STOCK OPTION PLAN

                     AS AMENDED EFFECTIVE NOVEMBER 19, 2001

     1.   Purposes of the Plan. The purposes of this Nonstatutory Stock Option
Plan are:

          o    to attract and retain the best available personnel for positions
               of substantial responsibility,

          o    to provide additional incentive to Employees and Consultants, and

          o    to promote the success of the Company's business.

          Options granted under the Plan will be Nonstatutory Stock Options.

          2.   Definitions. As used herein, the following definitions shall
apply:

          (a)  "Administrator" means the Board or any of its Committees as shall
be administering the Plan, in accordance with Section 4 of the Plan.

          (b)  "Applicable Laws" means the requirements relating to the
administration of stock option plans under U.S. state corporate laws, U.S.
federal and state securities laws, the Code, any stock exchange or quotation
system on which the Common Stock is listed or quoted and the applicable laws of
any foreign country or jurisdiction where Options are, or will be, granted under
the Plan.

          (c)  "Board" means the Board of Directors of the Company.

          (d)  "Code" means the Internal Revenue Code of 1986, as amended.

          (e)  "Committee" means a committee of Directors appointed by the Board
in accordance with Section 4 of the Plan.

          (f)  "Common Stock" means the Common Stock of the Company.

          (g)  "Company" means Quovadx, Inc., a Delaware corporation.

          (h)  "Consultant" means any person, including an advisor, engaged by
the Company or a Parent or Subsidiary to render services to such entity.

          (i)  "Director" means a member of the Board.

          (j)  "Disability" means total and permanent disability as defined in
Section 22(e)(3) of the Code.

<PAGE>

          (k)  "Employee" means any person, including Officers, employed by the
Company or any Parent or Subsidiary of the Company. A Service Provider shall not
cease to be an Employee in the case of (i) any leave of absence approved by the
Company or (ii) transfers between locations of the Company or between the
Company, its Parent, any Subsidiary, or any successor. Neither service as a
Director nor payment of a director's fee by the Company shall be sufficient to
constitute "employment" by the Company.

          (l)  "Exchange Act" means the Securities Exchange Act of 1934, as
amended.

          (m)  "Fair Market Value" means, as of any date, the value of Common
Stock determined as follows:

               (i)   If the Common Stock is listed on any established stock
exchange or a national market system, including without limitation the Nasdaq
National Market or The Nasdaq SmallCap Market of The Nasdaq Stock Market, its
Fair Market Value shall be the closing sales price for such stock (or the
closing bid, if no sales were reported) as quoted on such exchange or system for
the last market trading day prior to the time of determination, as reported in
The Wall Street Journal or such other source as the Administrator deems
reliable;

               (ii)  If the Common Stock is regularly quoted by a recognized
securities dealer but selling prices are not reported, the Fair Market Value of
a Share of Common Stock shall be the mean between the high bid and low asked
prices for the Common Stock on the last market trading day prior to the day of
determination, as reported in The Wall Street Journal or such other source as
the Administrator deems reliable;

               (iii) In the absence of an established market for the Common
Stock, the Fair Market Value shall be determined in good faith by the
Administrator.

          (n)  "Notice of Grant" means a written or electronic notice evidencing
certain terms and conditions of an individual Option grant. The Notice of Grant
is part of the Option Agreement.

          (o)  "Officer" means a person who is an officer of the Company within
the meaning of Section 16 of the Exchange Act and the rules and regulations
promulgated thereunder.

          (p)  "Option" means a nonstatutory stock option granted pursuant to
the Plan, that is not intended to qualify as an incentive stock option within
the meaning of Section 422 of the Code and the regulations promulgated
thereunder.

          (q)  "Option Agreement" means an agreement between the Company and an
Optionee evidencing the terms and conditions of an individual Option grant. The
Option Agreement is subject to the terms and conditions of the Plan.

          (r)  "Option Exchange Program" means a program whereby outstanding
options are surrendered in exchange for options with a lower exercise price.

                                      -2-

<PAGE>

          (s)  "Optioned Stock" means the Common Stock subject to an Option.

          (t)  "Optionee" means the holder of an outstanding Option granted
under the Plan.

          (u)  "Parent" means a "parent corporation," whether now or hereafter
existing, as defined in Section 424(e) of the Code.

          (v)  "Plan" means this 2000 Nonstatutory Stock Option Plan.

          (w)  "Service Provider" means an Employee or Consultant.

          (x)  "Share" means a share of the Common Stock, as adjusted in
accordance with Section 12 of the Plan.

          (y)  "Subsidiary" means a "subsidiary corporation," whether now or
hereafter existing, as defined in Section 424(f) of the Code.

     3.   Stock Subject to the Plan. Subject to the provisions of Section 12 of
the Plan, the maximum aggregate number of Shares which may be optioned and sold
under the Plan is 2,000,000 Shares. The Shares may be authorized, but unissued,
or reacquired Common Stock.

          If an Option expires or becomes unexercisable without having been
exercised in full, or is surrendered pursuant to an Option Exchange Program, the
unpurchased Shares which were subject thereto shall become available for future
grant or sale under the Plan (unless the Plan has terminated).

     4.   Administration of the Plan.

          (a)  Administration. The Plan shall be administered by (i) the Board
or (ii) a Committee, which committee shall be constituted to satisfy Applicable
Laws.

          (b)  Powers of the Administrator. Subject to the provisions of the
Plan, and in the case of a Committee, subject to the specific duties delegated
by the Board to such Committee, the Administrator shall have the authority, in
its discretion:

               (i)   to determine the Fair Market Value of the Common Stock;

               (ii)  to select the Service Providers to whom Options may be
granted hereunder;

               (iii) to determine whether and to what extent Options are granted
hereunder;

               (iv)  to determine the number of shares of Common Stock to be
covered by each Option granted hereunder;

               (v)   to approve forms of agreement for use under the Plan;

                                      -3-

<PAGE>

               (vi)   to determine the terms and conditions, not inconsistent
with the terms of the Plan, of any award granted hereunder. Such terms and
conditions include, but are not limited to, the exercise price, the time or
times when Options may be exercised (which may be based on performance
criteria), any vesting acceleration or waiver of forfeiture restrictions, and
any restriction or limitation regarding any Option or the shares of Common Stock
relating thereto, based in each case on such factors as the Administrator, in
its sole discretion, shall determine;

               (vii)  to reduce the exercise price of any Option to the then
current Fair Market Value if the Fair Market Value of the Common Stock covered
by such Option shall have declined since the date the Option was granted;

               (viii) to institute an Option Exchange Program;

               (ix)   to construe and interpret the terms of the Plan and awards
granted pursuant to the Plan;

               (x)    to prescribe, amend and rescind rules and regulations
relating to the Plan, including rules and regulations relating to sub-plans
established for the purpose of qualifying for preferred tax treatment under
foreign tax laws;

               (xi)   to modify or amend each Option (subject to Section 14(b)
of the Plan), including the discretionary authority to extend the
post-termination exercisability period of Options longer than is otherwise
provided for in the Plan;

               (xii)  to authorize any person to execute on behalf of the
Company any instrument required to effect the grant of an Option previously
granted by the Administrator;

               (xiii) to determine the terms and restrictions applicable to
Options;

               (xiv)  to allow Optionees to satisfy withholding tax obligations
by electing to have the Company withhold from the Shares to be issued upon
exercise of an Option that number of Shares having a Fair Market Value equal to
the amount required to be withheld. The Fair Market Value of the Shares to be
withheld shall be determined on the date that the amount of tax to be withheld
is to be determined. All elections by an Optionee to have Shares withheld for
this purpose shall be made in such form and under such conditions as the
Administrator may deem necessary or advisable; and

               (xv)   to make all other determinations deemed necessary or
advisable for administering the Plan.

          (c)  Effect of Administrator's Decision. The Administrator's
decisions, determinations and interpretations shall be final and binding on all
Optionees and any other holders of Options.

                                      -4-

<PAGE>

     5.   Eligibility. Options may be granted to Service Providers; provided,
however, that notwithstanding anything to the contrary contained in the Plan,
Options may not be granted to any Officer or Director of the Company.

     6.   Limitation. Neither the Plan nor any Option shall confer upon an
Optionee any right with respect to continuing the Optionee's relationship as a
Service Provider with the Company, nor shall they interfere in any way with the
Optionee's right or the Company's right to terminate such relationship at any
time, with or without cause.

     7.   Term of Plan. The Plan shall become effective upon its adoption by the
Board. It shall continue in effect for ten (10) years, unless sooner terminated
under Section 14 of the Plan.

     8.   Term of Option. The term of each Option shall be stated in the Option
Agreement.

     9.   Option Exercise Price and Consideration.

          (a)  Exercise Price. The per share exercise price for the Shares to be
issued pursuant to exercise of an Option shall be determined by the
Administrator.

          (b)  Waiting Period and Exercise Dates. At the time an Option is
granted, the Administrator shall fix the period within which the Option may be
exercised and shall determine any conditions which must be satisfied before the
Option may be exercised.

          (c)  Form of Consideration. The Administrator shall determine the
acceptable form of consideration for exercising an Option, including the method
of payment. Such consideration may consist entirely of:

               (i)   cash;

               (ii)  check;

               (iii) other Shares which (A) in the case of Shares acquired upon
exercise of an option, have been owned by the Optionee for more than six months
on the date of surrender, and (B) have a Fair Market Value on the date of
surrender equal to the aggregate exercise price of the Shares as to which said
Option shall be exercised;

               (iv) consideration received by the Company under a cashless
exercise program implemented by the Company in connection with the Plan;

               (v)  a reduction in the amount of any Company liability to the
Optionee, including any liability attributable to the Optionee's participation
in any Company-sponsored deferred compensation program or arrangement;

               (vi) such other consideration and method of payment for the
issuance of Shares to the extent permitted by Applicable Laws; or

                                      -5-

<PAGE>

               (vii) any combination of the foregoing methods of payment.

     10.  Exercise of Option.

          (a)  Procedure for Exercise; Rights as a Shareholder. Any Option
granted hereunder shall be exercisable according to the terms of the Plan and at
such times and under such conditions as determined by the Administrator and set
forth in the Option Agreement. An Option may not be exercised for a fraction of
a Share.

               An Option shall be deemed exercised when the Company receives:
(i) written or electronic notice of exercise (in accordance with the Option
Agreement) from the person entitled to exercise the Option, and (ii) full
payment for the Shares with respect to which the Option is exercised. Full
payment may consist of any consideration and method of payment authorized by the
Administrator and permitted by the Option Agreement and the Plan. Shares issued
upon exercise of an Option shall be issued in the name of the Optionee or, if
requested by the Optionee, in the name of the Optionee and his or her spouse.
Until the Shares are issued (as evidenced by the appropriate entry on the books
of the Company or of a duly authorized transfer agent of the Company), no right
to vote or receive dividends or any other rights as a shareholder shall exist
with respect to the Optioned Stock, notwithstanding the exercise of the Option.
The Company shall issue (or cause to be issued) such Shares promptly after the
Option is exercised. No adjustment will be made for a dividend or other right
for which the record date is prior to the date the Shares are issued, except as
provided in Section 12 of the Plan.

               Exercising an Option in any manner shall decrease the number of
Shares thereafter available, both for purposes of the Plan and for sale under
the Option, by the number of Shares as to which the Option is exercised.

          (b)  Termination of Relationship as a Service Provider. If an Optionee
ceases to be a Service Provider, other than upon the Optionee's death or
Disability, the Optionee may exercise his or her Option, but only within such
period of time as is specified in the Option Agreement, and only to the extent
that the Option is vested on the date of termination (but in no event later than
the expiration of the term of such Option as set forth in the Option Agreement).
In the absence of a specified time in the Option Agreement, the Option shall
remain exercisable for three (3) months following the Optionee's termination.
If, on the date of termination, the Optionee is not vested as to his or her
entire Option, the Shares covered by the unvested portion of the Option shall
revert to the Plan. If, after termination, the Optionee does not exercise his or
her Option within the time specified by the Administrator, the Option shall
terminate, and the Shares covered by such Option shall revert to the Plan.

          (c)  Disability of Optionee. If an Optionee ceases to be a Service
Provider as a result of the Optionee's Disability, the Optionee may exercise his
or her Option within such period of time as is specified in the Option
Agreement, to the extent the Option is vested on the date of termination (but in
no event later than the expiration of the term of such Option as set forth in
the Option Agreement). In the absence of a specified time in the Option
Agreement, the Option shall remain exercisable for twelve (12) months following
the Optionee's termination. If, on the date of

                                      -6-

<PAGE>

termination, the Optionee is not vested as to his or her entire Option, the
Shares covered by the unvested portion of the Option shall revert to the Plan.
If, after termination, the Optionee does not exercise his or her Option within
the time specified herein, the Option shall terminate, and the Shares covered by
such Option shall revert to the Plan.

          (d)  Death of Optionee. If an Optionee dies while a Service Provider,
the Option may be exercised within such period of time as is specified in the
Option Agreement (but in no event later than the expiration of the term of such
Option as set forth in the Notice of Grant), by the Optionee's estate or by a
person who acquires the right to exercise the Option by bequest or inheritance,
but only to the extent that the Option is vested on the date of death. In the
absence of a specified time in the Option Agreement, the Option shall remain
exercisable for twelve (12) months following the Optionee's termination. If, at
the time of death, the Optionee is not vested as to his or her entire Option,
the Shares covered by the unvested portion of the Option shall immediately
revert to the Plan. The Option may be exercised by the executor or administrator
of the Optionee's estate or, if none, by the person(s) entitled to exercise the
Option under the Optionee's will or the laws of descent or distribution. If the
Option is not so exercised within the time specified herein, the Option shall
terminate, and the Shares covered by such Option shall revert to the Plan.

          (e)  Buyout Provisions. The Administrator may at any time offer to buy
out for a payment in cash or Shares, an Option previously granted based on such
terms and conditions as the Administrator shall establish and communicate to the
Optionee at the time that such offer is made.

     11.  Non-Transferability of Options. Unless determined otherwise by the
Administrator, an Option may not be sold, pledged, assigned, hypothecated,
transferred, or disposed of in any manner other than by will or by the laws of
descent or distribution and may be exercised, during the lifetime of the
Optionee, only by the Optionee. If the Administrator makes an Option
transferable, such Option shall contain such additional terms and conditions as
the Administrator deems appropriate.

     12.  Adjustments Upon Changes in Capitalization, Dissolution, Merger or
Asset Sale.

          (a)  Changes in Capitalization. Subject to any required action by the
shareholders of the Company, the number of shares of Common Stock covered by
each outstanding Option, and the number of shares of Common Stock which have
been authorized for issuance under the Plan but as to which no Options have yet
been granted or which have been returned to the Plan upon cancellation or
expiration of an Option, as well as the price per share of Common Stock covered
by each such outstanding Option, shall be proportionately adjusted for any
increase or decrease in the number of issued shares of Common Stock resulting
from a stock split, reverse stock split, stock dividend, combination or
reclassification of the Common Stock, or any other increase or decrease in the
number of issued shares of Common Stock effected without receipt of
consideration by the Company; provided, however, that conversion of any
convertible securities of the Company shall not be deemed to have been "effected
without receipt of consideration." Such adjustment shall be made by the Board,
whose determination in that respect shall be final, binding and conclusive.
Except as expressly provided herein, no issuance by the Company of shares of
stock of any class, or securities

                                      -7-

<PAGE>

convertible into shares of stock of any class, shall affect, and no adjustment
by reason thereof shall be made with respect to, the number or price of shares
of Common Stock subject to an Option.

          (b)  Dissolution or Liquidation. In the event of the proposed
dissolution or liquidation of the Company, the Administrator shall notify each
Optionee as soon as practicable prior to the effective date of such proposed
transaction. The Administrator in its discretion may provide for an Optionee to
have the right to exercise his or her Option until ten (10) days prior to such
transaction as to all of the Optioned Stock covered thereby, including Shares as
to which the Option would not otherwise be exercisable. In addition, the
Administrator may provide that any Company repurchase option applicable to any
Shares purchased upon exercise of an Option shall lapse as to all such Shares,
provided the proposed dissolution or liquidation takes place at the time and in
the manner contemplated. To the extent it has not been previously exercised, an
Option will terminate immediately prior to the consummation of such proposed
action.

          (c)  Merger or Asset Sale. In the event of a merger of the Company
with or into another corporation, or the sale of substantially all of the assets
of the Company, each outstanding Option shall be assumed or an equivalent option
or right substituted by the successor corporation or a Parent or Subsidiary of
the successor corporation. In the event that the successor corporation refuses
to assume or substitute for the Option, the Optionee shall fully vest in and
have the right to exercise the Option as to all of the Optioned Stock, including
Shares as to which it would not otherwise be vested or exercisable. If an Option
becomes fully vested and exercisable in lieu of assumption or substitution in
the event of a merger or sale of assets, the Administrator shall notify the
Optionee in writing or electronically that the Option shall be fully vested and
exercisable for a period of fifteen (15) days from the date of such notice, and
the Option shall terminate upon the expiration of such period. For the purposes
of this paragraph, the Option shall be considered assumed if, following the
merger or sale of assets, the option or right confers the right to purchase or
receive, for each Share of Optioned Stock, immediately prior to the merger or
sale of assets, the consideration (whether stock, cash, or other securities or
property) received in the merger or sale of assets by holders of Common Stock
for each Share held on the effective date of the transaction (and if holders
were offered a choice of consideration, the type of consideration chosen by the
holders of a majority of the outstanding Shares); provided, however, that if
such consideration received in the merger or sale of assets is not solely common
stock of the successor corporation or its Parent, the Administrator may, with
the consent of the successor corporation, provide for the consideration to be
received upon the exercise of the Option, for each Share of Optioned Stock to be
solely common stock of the successor corporation or its Parent equal in fair
market value to the per share consideration received by holders of Common Stock
in the merger or sale of assets.

     13.  Date of Grant. The date of grant of an Option shall be, for all
purposes, the date on which the Administrator makes the determination granting
such Option, or such other later date as is determined by the Administrator.
Notice of the determination shall be provided to each Optionee within a
reasonable time after the date of such grant.

     14.  Amendment and Termination of the Plan.

                                      -8-

<PAGE>

          (a)  Amendment and Termination. The Board may at any time amend,
alter, suspend or terminate the Plan.

          (b) Effect of Amendment or Termination. No amendment, alteration,
suspension or termination of the Plan shall impair the rights of any Optionee,
unless mutually agreed otherwise between the Optionee and the Administrator,
which agreement must be in writing and signed by the Optionee and the Company.
Termination of the Plan shall not affect the Administrator's ability to exercise
the powers granted to it hereunder with respect to options granted under the
Plan prior to the date of such termination.

     15.  Conditions Upon Issuance of Shares.

          (a)  Legal Compliance. Shares shall not be issued pursuant to the
exercise of an Option unless the exercise of such Option and the issuance and
delivery of such Shares shall comply with Applicable Laws and shall be further
subject to the approval of counsel for the Company with respect to such
compliance.

          (b)  Investment Representations. As a condition to the exercise of an
Option the Company may require the person exercising such Option to represent
and warrant at the time of any such exercise that the Shares are being purchased
only for investment and without any present intention to sell or distribute such
Shares if, in the opinion of counsel for the Company, such a representation is
required.

     16.  Inability to Obtain Authority. The inability of the Company to obtain
authority from any regulatory body having jurisdiction, which authority is
deemed by the Company's counsel to be necessary to the lawful issuance and sale
of any Shares hereunder, shall relieve the Company of any liability in respect
of the failure to issue or sell such Shares as to which such requisite authority
shall not have been obtained.

     17.  Reservation of Shares. The Company, during the term of this Plan, will
at all times reserve and keep available such number of Shares as shall be
sufficient to satisfy the requirements of the Plan.

                                      -9-
<PAGE>
                                  ATTACHMENT 1

                                       TO

  NOTICE OF GRANT OF STOCK OPTIONS FROM THE 2000 NONSTATUTORY STOCK OPTION PLAN
                              AND OPTION AGREEMENT

I.       NOTICE

         Vesting Schedule:

         Subject to the Optionee continuing to be a Service Provider on such
dates, this Option shall vest and become exercisable in accordance with the
following schedule:

         25% of the Shares subject to the Option shall vest twelve (12) months
after the effective date of grant (the Vesting Commencement Date), and 1/48th of
the Shares subject to the Option shall vest each month thereafter on the same
day of the month as the Vesting Commencement Date. The options shall become
fully exercisable upon change of control of the Company.

         "Change of Control" shall mean the occurrence of any of the following
events: (i) Any "person" (as such term is used in Sections 13(d) and 14(d)of the
Exchange Act) becomes the "beneficial owner" (as defined in Rule 13d-3 of the
Exchange Act), directly or indirectly, of securities of the Company representing
fifty percent (50%) or more of the total voting power represented by the
Company's then outstanding voting securities; or (ii) The consummation of the
sale or disposition by the Company of all or substantially all of the Company's
assets; or (iii) The consummation of a merger or consolidation of the Company,
with any other corporation, other than a merger or consolidation which would
result in the voting securities of the Company outstanding immediately prior
thereto continuing to represent (either by remaining outstanding or by being
converted into voting securities of the surviving entity or its parent) at least
fifty percent (50%) of the total voting power represented by the voting
securities of the Company, or such surviving entity or its parent outstanding
immediately after such merger or consolidation, or (iv) A change in the
composition of the Board, as a result of which fewer than a majority of the
Directors are Incumbent Directors. "Incumbent Directors" shall mean Directors
who either (A) are Directors of the Company, as applicable, as of the date
hereof, or (B) are elected, or nominated for election, to the Board with the
affirmative votes of at least a majority of those Directors whose election or
nomination was not in connection with any transaction described in subsections
(i), (ii) or (iii) or in connection with an actual or threatened proxy contest
relating to the election of directors of the Company.

         Termination Period:

         This Option may be exercised, to the extent vested on the date of
termination, for three (3) months after Optionee ceases to be a Service
Provider. Notwithstanding the foregoing, upon the death or disability of the
Optionee, this Option may be exercised, to the extent vested on the date of
death or termination, for twelve (12) months after Optionee ceases to be a
Service Provider. In no event shall this Option be exercised later than the
Term/Expiration Date as provided above.

                                       -2-
<PAGE>

     II.      AGREEMENT

         1. Grant of Option. The Plan Administrator of the Company hereby grants
to the Optionee named in the Notice of Grant attached as Part I of this
Agreement (the "Optionee") an option (the "Option") to purchase the number of
Shares, as set forth in the Notice of Grant, at the exercise price per share set
forth in the Notice of Grant (the "Exercise Price"), subject to the terms and
conditions of the Plan, which is incorporated herein by reference. Subject to
Section 14(b) of the Plan, in the event of a conflict between the terms and
conditions of the Plan and the terms and conditions of this Option Agreement,
the terms and conditions of the Plan shall prevail.

         2.       Exercise of Option.

                  (a)  Right to Exercise. This Option is exercisable during its
term in accordance with the Vesting Schedule set out in the Notice of Grant and
the applicable provisions of the Plan and this Option Agreement.

                  (b) Method of Exercise. This Option is exercisable by delivery
to the Company of a written or electronic notice of exercise, substantially in
the form attached as Exhibit A (the "Exercise Notice"), which shall state the
election to exercise the Option, the number of Shares in respect of which the
Option is being exercised (the "Exercised Shares"), and such other
representations and agreements as may be required by the Company pursuant to the
provisions of the Plan. The Exercise Notice shall be accompanied by payment of
the aggregate Exercise Price as to all Exercised Shares. This Option, or portion
of this Option, shall be deemed to be exercised upon receipt by the Company of
such Exercise Notice accompanied by such aggregate Exercise Price.

                  No Shares shall be issued pursuant to the exercise of this
Option unless such issuance and exercise complies with Applicable Laws. Assuming
such compliance, for income tax purposes the Exercised Shares shall be
considered transferred to the Optionee on the date the Option is exercised with
respect to such Exercised Shares.

         3.       Method of Payment. Payment of the aggregate Exercise Price
shall be by any of the following, or a combination thereof, at the election of
the Optionee:

                      (a)  cash;

                      (b)  check;

                      (c)  consideration received by the Company under a
cashless exercise program implemented by the Company in connection with the
Plan; or

                      (d)  surrender of other Shares, provided Shares acquired
from the Company, (i) have been owned by the Optionee for more than six (6)
months on the date of surrender, AND (ii) have a Fair Market Value on the date
of surrender equal to the aggregate Exercise Price of the exercised shares.

         4.       Non-Transferability of Option. This Option may not be
transferred in any manner otherwise than by will or by the laws of descent or
distribution and may be exercised during the lifetime of Optionee only by the
Optionee. The terms of the Plan and this Option Agreement shall be binding upon
the executors, administrators, heirs, successors and assigns of the Optionee.

                                      -3-
<PAGE>

         5.       Term of Option. This Option may be exercised only within the
term set out in the Notice of Grant, and may be exercised during such term only
in accordance with the Plan and the terms of this Option Agreement.

         6.       Tax Consequences. Some of the federal tax consequences
relating to this Option, as of the date of this Option, are set forth below.
THIS SUMMARY IS NECESSARILY INCOMPLETE, AND THE TAX LAWS AND REGULATIONS ARE
SUBJECT TO CHANGE. THE OPTIONEE SHOULD CONSULT A TAX ADVISER BEFORE EXERCISING
THIS OPTION OR DISPOSING OF THE SHARES.

                      (a)  Exercising the Option. The Optionee may incur regular
federal income tax liability upon exercise of an NSO. The Optionee will be
treated as having received compensation income (taxable at ordinary income tax
rates) equal to the excess, if any, of the Fair Market Value of the Exercised
Shares on the date of exercise over their aggregate Exercise Price. If the
Optionee is an Employee or a former Employee, the Company will be required to
withhold from his or her compensation or collect from Optionee and pay to the
applicable taxing authorities an amount in cash equal to a percentage of this
compensation income at the time of exercise, and may refuse to honor the
exercise and refuse to deliver Shares if such withholding amounts are not
delivered at the time of exercise.

                      (b)  Disposition of Shares. If the Optionee holds NSO
Shares for at least one year, any gain realized on disposition of the Shares
will be treated as long-term capital gain for federal income tax purposes.

         7.      Entire Agreement; Governing Law. The Plan is incorporated
herein by reference. The Plan and this Option Agreement constitute the entire
agreement of the parties with respect to the subject matter hereof and supersede
in their entirety all prior undertakings and agreements of the Company and
Optionee with respect to the subject matter hereof, and may not be modified
adversely to the Optionee's interest except by means of a writing signed by the
Company and Optionee. This agreement is governed by the internal substantive
laws, but not the choice of law rules, of Colorado.

         8.      NO GUARANTEE OF CONTINUED SERVICE. OPTIONEE ACKNOWLEDGES AND
AGREES THAT THE VESTING OF SHARES PURSUANT TO THE VESTING SCHEDULE HEREOF IS
EARNED ONLY BY CONTINUING AS A SERVICE PROVIDER AT THE WILL OF THE COMPANY (AND
NOT THROUGH THE ACT OF BEING HIRED, BEING GRANTED AN OPTION OR PURCHASING SHARES
HEREUNDER). OPTIONEE FURTHER

         9.      ACKNOWLEDGES AND AGREES THAT THIS AGREEMENT, THE TRANSACTIONS
CONTEMPLATED HEREUNDER AND THE VESTING SCHEDULE SET FORTH HEREIN DO NOT
CONSTITUTE AN EXPRESS OR IMPLIED PROMISE OF CONTINUED ENGAGEMENT AS A SERVICE
PROVIDER FOR THE VESTING PERIOD, FOR ANY PERIOD, OR AT ALL, AND SHALL NOT
INTERFERE WITH OPTIONEE'S RIGHT OR THE COMPANY'S RIGHT TO TERMINATE OPTIONEE'S
RELATIONSHIP AS A SERVICE PROVIDER AT ANY TIME, WITH OR WITHOUT CAUSE.

         By Optionee's signature and the signature of the Company's
representative above, Optionee and the Company agree that this Option is granted
under and governed by the terms and conditions of the Plan and this Option
Agreement. Optionee has reviewed the Plan and this Option Agreement in their
entirety, has had an opportunity to obtain the advice of counsel prior to
executing this Option

                                      -4-
<PAGE>

Agreement and fully understands all provisions of the Plan and Option Agreement.
Optionee hereby agrees to accept as binding, conclusive and final all decisions
or interpretations of the Administrator upon any questions relating to the Plan
and Option Agreement. Optionee further agrees to notify the Company upon any
change in the residence address indicated above.

                                      -5-
<PAGE>

                                    EXHIBIT A

                                  QUOVADX, INC.

                       2000 NONSTATUTORY STOCK OPTION PLAN
                                 EXERCISE NOTICE

Quovadx, Inc.
6400 South Fiddlers Green Circle
Suite 1000
Englewood, Colorado 80111
Attention:  Human Resources

     1.  Exercise of Option. Effective as of today, ________________, _____, the
         undersigned ("Purchaser") hereby elects to purchase ______________
         shares (the "Shares") of the Common Stock of Quovadx, Inc. (the
         "Company") under and pursuant to the 2000 Nonstatutory Stock Option
         Plan (the "Plan") and the Stock Option Agreement dated, _________, ___
         (the "Option Agreement"). The purchase price for the Shares shall be
         $__________, as required by the Option Agreement.

     2.  Delivery of Payment. Purchaser herewith delivers to the Company the
         full purchase price for the Shares.

     3.  Representations of Purchaser. Purchaser acknowledges that Purchaser has
         received, read and understood the Plan and the Option Agreement and
         agrees to abide by and be bound by their terms and conditions.

     4.  Rights as Shareholder. Until the issuance (as evidenced by the
         appropriate entry on the books of the Company or of a duly authorized
         transfer agent of the Company) of the Shares, no right to vote or
         receive dividends or any other rights as a shareholder shall exist with
         respect to the Optioned Stock, notwithstanding the exercise of the
         Option. The Shares so acquired shall be issued to the Optionee as soon
         as practicable after exercise of the Option. No adjustment will be made
         for a dividend or other right for which the record date is prior to the
         date of issuance, except as provided in Section 12 of the Plan.

     5.  Tax Consultation. Purchaser understands that Purchaser may suffer
         adverse tax consequences as a result of Purchaser's purchase or
         disposition of the Shares. Purchaser represents that Purchaser has
         consulted with any tax consultants Purchaser deems advisable in
         connection with the purchase or disposition of the Shares and that
         Purchaser is not relying on the Company for any tax advice.

     6.  Entire Agreement; Governing Law. The Plan and Option Agreement are
         incorporated herein by reference. This Agreement, the Plan and the
         Option Agreement constitute the entire agreement of the parties with
         respect to the subject matter hereof and supersede in their entirety
         all prior undertakings and agreements of the Company and Purchaser with
         respect to the subject matter hereof, and may not be modified adversely
         to the Purchaser's interest

<PAGE>

         except by means of a writing signed by the Company and Purchaser. This
         agreement is governed by the internal substantive laws, but not the
         choice of law rules, of Colorado.

         Submitted by:                          Accepted by:

         PURCHASER                              QUOVADX, INC.

         -----------------------------          ------------------------------

         Signature                              By

         -----------------------------          ------------------------------

         Print Name                             Title

         -----------------------------          ------------------------------

                                                Date Received
                                                               ---------------
         Address:                               Address:

         -----------------------------          6400 South Fiddlers Green Circle
         -----------------------------          Suite 1000
         -----------------------------          Englewood, CO 80111

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