Document:

EX-10.3

 Exhibit 10.3 

ELOXX PHARMACEUTICALS, INC. 

ISRAELI SUB - PLAN 

 

	1.	PREAMBLE 

  

	 	(a)	This Israeli Sub-Plan (the “Sub-Plan”) shall apply only to Participants who are residents or citizens of the State of
Israel or those who are deemed to be residents or citizens of the State of Israel for the payment of tax (the “Israeli Participants”). The provisions specified hereunder shall form an integral part of the Eloxx Pharmaceuticals Inc.
2018 Equity Incentive Plan to which this Sub-Plan is attached (the “Plan”). For the avoidance of doubt, this Sub-Plan does not add to or modify the Plan
in respect of any other category of Participants. 

  

	 	(b)	The Plan and this Sub-Plan are complementary to each other and shall be deemed one. In any case of contradiction, whether explicit or implied, between the provisions of this Sub-Plan and the Plan, the provisions set out in this Sub-Plan shall prevail with respect to Awards granted to Israeli Participants. 

 

	 	(c)	Any capitalized terms not specifically defined in this Sub-Plan shall be construed according to the interpretation given to them in the Plan. The Plan administrator shall have
full and binding authority to construe and interpret the terms of this Sub-Plan, and any such determinations shall be final and binding on all parties. 

 

	 	(d)	The purpose and intent of the Sub-Plan is to provide incentives to employees, directors, officers, service providers, consultants and/or advisors of the Company and/or any
Affiliate who are Israeli Participants by providing them with the opportunity to benefit from increases in value of the Common Stock through the issuance of shares, Options, Restricted Stock Awards, Restricted Stock Unit Awards and other Stock
Awards. 

 This Sub-Plan is to be read as a continuation of the Plan and only refers to
Awards granted to Israeli Participants so that they comply with the requirements set by the Israeli law in general and in particular with Section 102 of the Israeli Income Tax Ordinance (New Version), 1961, as amended from time to time, or any
provision which may amend or replace it (the “Ordinance” and “Section 102”) and the rules, regulations and orders or procedures promulgated thereunder from time to time, as amended or replaced
from time to time (the “Rules”) and to enable the Company and the Israeli Participants hereunder to benefit from Section 102 and the Rules and also to enable the Company to grant Awards and issue shares outside the context of
Section 102. The Company, however, does not warrant that the Plan and Sub-Plan will be recognized by the income tax authorities or that future changes will not be made to the provisions of the law,
regulations or the Rules, which are promulgated from time to time, or that any exemption or benefit currently available pursuant to Section 102 will not be abolished. 
  

	 	(e)	Should any provision of Section 102, regulations thereunder or the Rules which apply to employees or any such other Participants who are Israeli Participants as applicable under the provisions of Section 102
and the Rules, be amended, such amendment shall be deemed included in the Sub-Plan with respect to Awards granted or shares issued in the context of Section 102. Where a conflict arises between any
section of the Sub-Plan, the Award Agreement or their application, and the provisions of any tax law, rule or regulations, including without limitation the Ordinance and/or the Rules, whether relied upon for
tax relief or otherwise, the latter shall prevail, and the Board or the Committee in its sole discretion shall determine the necessary changes to be made to the Sub-Plan and its determination regarding this
matter shall be final and binding. 

	 	(f)	The Sub-Plan shall be administered by the Board or the Committee as further set forth in the Plan. Subject to applicable law and without derogating from the generality of the
Plan, the Board shall have plenary authority to determine whether or not an Award shall be granted pursuant to Section 102, and if so, whether such Award be granted to a trustee under the Ordinance and the election of the “Ordinary Income
Route” according to Section 102(b)(1) of the Ordinance or the “Capital Gains Route” according to Section 102(b)(2) of the Ordinance or otherwise (Awards granted either under the Ordinary Income Route or under the Capital
Gains Route shall be referred to herein as “Approved 102 Awards”), or without a trustee according to Section 102(c) of the Ordinance (the “Unapproved 102 Awards”). 

 

	 	(g)	No director or officer of the Company shall be personally liable or obligated to any Participant as a result of any decision made and/or action taken with respect to the Sub-Plan
or its interpretation or execution. 

  

	2.	DESIGNATION OF ISRAELI PARTICIPANTS 

  

	 	(a)	The persons eligible for participation in the Sub-Plan as Israeli Participants shall include any employee, director, service provider, consultant and/or advisors of the Company or
any Affiliate or any other person or entity so designated by the Board, provided that for the purpose of the Israeli tax law, Israeli Employees (as defined herein) may only be granted Awards under Section 102 of the Ordinance; and Israeli Non-Employees (as defined below) may only be granted Awards under Section 3(i) of the Ordinance. 

For the purpose of this Section: 

“Israeli Employee” shall mean a person who is employed by the Company or its Affiliate, which is an “employing
company” within the meaning of Section 102(a) of the Ordinance, including an individual who is serving as a director or an office holder, but excluding Controlling Shareholder, who is an Israeli resident or deemed to be an Israeli resident
for the payment of tax. 
 “Controlling Shareholder” shall have the meaning ascribed to it in Section 32(9) of the
Ordinance. 
 “Israeli Non-Employees” shall mean a consultant, adviser, service
provider, Controlling Shareholder or any other person who is not an Israeli Employee, who is an Israeli resident or deemed to be an Israeli resident for the payment of tax. 
  

	 	(b)	The grant of an Award hereunder shall neither entitle the Israeli Participant to participate nor disqualify the Israeli Participant from participating in, any other grant of Awards pursuant to the Plan or any other
Award or share plan of the Company or any Affiliate. 

  

	3.	DESIGNATION OF AWARDS PURSUANT TO SECTION 102 

  

	 	(a)	The Company may designate Awards granted to Israeli Employees pursuant to Section 102 as Unapproved 102 Awards or Approved 102 Awards. 

 

	 	(b)	The grant of Approved 102 Awards shall be made under this Sub-Plan adopted by the Board, and shall be conditioned upon the approval of this
Sub-Plan by the ITA. 

  

	 	(c)	Approved 102 Award may either be classified as Capital Gain Award (“CGO”) or Ordinary Income Award (“OIO”). 

 

	 	(d)	Approved 102 Award elected and designated by the Company to qualify under the capital gain tax treatment in accordance with the provisions of Section 102(b)(2) shall be referred to herein as CGO. 

 

	 	(e)	Approved 102 Award elected and designated by the Company to qualify under the ordinary income tax treatment in accordance with the provisions of Section 102(b)(1) shall be referred to herein as OIO.

  
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	 	(f)	The Company’s election of the type of Approved 102 Awards as CGO or OIO granted to Israeli Employees (the “Election”), shall be appropriately filed with the ITA before the date of grant of an
Approved 102 Award. Such Election shall become effective beginning the first date of grant of an Approved 102 Award under this Plan and shall remain in effect at least until the end of the year following the year during which the Company first
granted Approved 102 Awards. The Election shall obligate the Company to grant only the type of Approved 102 Award it has elected, and shall apply to all Israeli Participants who were granted Approved 102 Awards during the period indicated herein,
all in accordance with the provisions of Section 102(g) of the Ordinance. For the avoidance of doubt, such Election shall not prevent the Company from granting Unapproved 102 Awards or any other Awards simultaneously. 

 

	 	(g)	All Approved 102 Awards must be held in trust by a Trustee, as described below. 

  

	 	(h)	For the avoidance of doubt, the designation of Unapproved 102 Awards and Approved 102 Awards shall be subject to the terms and conditions set forth in Section 102 of the Ordinance and the regulations promulgated
thereunder. 

  

	 	(i)	With regards to Approved 102 Awards, the provisions of the Sub-Plan and/or the Award Agreement (as defined in the Plan) shall be subject to the provisions of Section 102 and
the Tax Assessing Officer’s permit, and the said provisions and permit shall be deemed an integral part of the Sub-Plan and of the Award Agreement. Any provision of Section 102 and/or the said permit
which is necessary in order to receive and/or to keep any tax benefit pursuant to Section 102, which is not expressly specified in the Sub-Plan or the Award Agreement, shall be considered binding upon the
Company and the Israeli Participants. 

  

	4.	GRANT OF THE AWARDS AND ISSUANCE OF THE SHARES TO THE TRUSTEE  

  

	 	(a)	Shares issued upon exercise of an Award shall be issued to the Israeli Participant or to the Trustee (as such term is defined below), in the name of the Israeli Participant and on his or her behalf, subject to the sole
discretion of the Board. In the event that the Board grants an Award to be held by the Israeli Participant directly, and unless determined otherwise with respect to a specific grant, then without derogating from any other rights or obligations
conveyed to the Israeli Participant according to the Sub-Plan all rights and obligations conveyed to the Trustee according to this Sub-Plan shall be awarded to the said
Israeli Participant. 

  

	 	(b)	The Board shall appoint a Trustee for the purposes of this Sub-Plan (the “Trustee”). In case of a Trustee nominated under Section 102, the nomination of such
Trustee shall be subject to the approval of the Israeli Income Tax Authorities (the “ITA”) in accordance with the provisions of Section 102(a) of the Ordinance. The Trustee shall have all the powers provided by law, including,
without limitation, the Ordinance, Section 102 and the Rules, the trust agreement with the Company and/or any Affiliate thereof, and the Sub-Plan and shall act pursuant to the provisions thereof, as they
shall apply from time to time. The Board or the Committee shall be entitled to replace the Trustee and/or to nominate another person to serve as a Trustee in lieu of the existing Trustee at its sole discretion, subject to applicable law, and that
the new Trustee shall have the same powers and authority which this Sub-Plan grants the Trustee. 

  

	 	(c)	 Unless otherwise determined by the Board, all Award including, without limitation, the shares issued pursuant
thereto, and all rights deriving from or in connection therewith, including, without limitation, any bonus shares (including stock dividends) issued in connection therewith, shall be issued by the Company in the name of the Trustee on behalf of the
Israeli Participant and the share certificates representing any shares issued pursuant to Awards exercised hereunder, shall be issued by the Company in the name of the Trustee in trust for the designated Israeli Participant and shall be deposited
with the Trustee, held by him and registered in his name in the register of shareholders of the Company for such period as determined by the Board but, in the case of Approved 102 

  
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Awards, not less than the period set forth therein or otherwise required, or approved, with respect thereto pursuant to Israeli law, regulations promulgated thereunder, the Ordinance,
Section 102 or the Rules, as shall be in effect from time to time (the “Restriction Period”) and the same tax route pursuant to Section 102 shall apply thereto. Furthermore, Approved 102 Awards granted or shares issued
pursuant to such Approved 102 Awards shall not be sold or transferred until the end of the Restriction Period, unless otherwise allowed or determined by the Israeli tax authorities. Notwithstanding the above, if any such sale or transfer occurs
during the Restriction Period, the sanctions under Section 102 of the Ordinance and under the Rules or regulation or orders or procedures promulgated thereunder shall apply to and shall be borne by such Israeli Participant. 

Notwithstanding anything to the contrary, the Trustee shall not release any shares, income of appropriation allocated or issued upon exercise
of Approved 102 Awards prior to the full payment of the Israeli Participant’s tax liabilities arising from Approved 102 Awards which were granted to him/her and/or any shares allocated or issued upon exercise of such Awards. 

 

	 	(d)	Unless otherwise determined by the Board, Awards granted hereunder shall not confer upon the Israeli Participant any of the rights of a shareholder of the Company, for as long as they have not been exercised and, once
exercised, for as long as the shares have not been issued, transferred and registered in the Israeli Participant’s name in the Company’s shareholder register. 

 

	 	(e)	Nothing in the aforegoing provisions shall derogate from the power of the Board to grant Awards or to allot shares to the Trustee otherwise than under the provisions of Section 102 and the Rules or to allot shares
or grant Awards to Israeli Participants directly otherwise than through the Trustee or on terms which differ from those specified above or to approve the transfer of shares from the Trustee to the name of any Israeli Participant(s) upon such
conditions as shall be determined by the Board. 

  

	5.	AWARD OR SHARE PURCHASE AGREEMENT 

 Unless otherwise determined by the Board, every
Israeli Participant shall be required to sign an Award Agreement. 
 The Award Agreement need not be identical with respect to each Israeli
Participant. The following terms, however, shall apply to all Awards, and, mutatis mutandis, shares, unless otherwise determined by the Board or set forth in the Israeli Participant’s Award Agreement: 

 

	 	(a)	The Awards granted to Israeli Participants pursuant to Section 102 and the Rules are personal and except insofar as is specified in this Sub-Plan, may not be transferred,
assigned, pledged, withheld, attached or otherwise charged either voluntarily or pursuant to any law, except by way of transfer pursuant to the laws of inheritance or as otherwise determined by the Board, and no power of attorney or deed of
transfer, whether the same has immediate effect or shall take effect on a future date, shall be given with respect thereto. During the lifetime of such Israeli Participant the Award may only be exercised by the designated Israeli Participant or, if
granted to the Trustee, by the Trustee on behalf of the designated Israeli Participant. A note as to the provisions of this sub-section or a legend may appear on any document which grants the Award and in
particular in the Award Agreement, and also on any share certificate. 

  

	 	(b)	The right to exercise the Award is granted to the Trustee on behalf of the Israeli Participant and maybe subject to a vesting schedule, and may be further subject to any performance goals and measurements as may be
determined by the Board, provided that, unless otherwise determined by the Board or set forth in the respective Award Agreement, upon each of such vesting dates the Israeli Participant continues to be employed by, or provide services to, or serve as
a director or officer of the Company or an Affiliate on a continual basis from the date of the grant thereof. 

  
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	 	(c)	The Board may determine at its sole discretion, that any Israeli Participant shall be entitled to receive the Awards or the shares, through the Trustee, pursuant to the provisions of this
Sub-Plan or, subject to the provisions of Section 102, as applicable, directly in the name of the Israeli Participant, immediately upon execution of the Award Agreement or on such other date or dates as
the Company has undertaken towards such Israeli Participant. The Board shall be entitled, subject to applicable law, to determine that where the Israeli Participant does not comply with the conditions determined by the Board or the Award Agreement
or ceases to be an employee of or to provide services to serve as an officer or director of the Company or an Affiliate, the Company or an Affiliate shall have the right to repurchase the shares from the Israeli Participant for the higher of:
(i) nominal or (ii) any other consideration paid by the Israeli Participant, subject to applicable law. The Board may set additional conditions to this right of repurchase. For as long as the aforegoing conditions of the Board (including,
without limitation, a minimum period of employment, other engagement or appointment as a condition for the lapse of the right to reacquisition) have not been complied with, or have not lapsed, as applicable, the Israeli Participant shall not be
entitled to sell or charge or transfer in any other manner the shares which are subject to the right of reacquisition. As security for the compliance with this undertaking the share certificate will be deposited with the Trustee who will release the
same to the Israeli Participant only after the Israeli Participant becomes entitled to the shares and the same are not subject to any other restrictive condition. 

 

	 	(d)	The Award Agreement shall be further subject to the Plan in connection with termination of Continuous Service, acceleration upon a Change of Control, exercise price, dividends, and vesting. 

 

	6.	TERM OF AWARDS; EXERCISE 

  

	 	(a)	The term of each Award shall be as set forth in the Plan or the Award Agreement, subject to an early termination in connection with a Change of Control and other circumstances set forth in the Plan. 

 

	 	(b)	An Israeli Participant who desires that the Trustee exercise an Award granted to the Trustee on his behalf shall so instruct the Trustee in writing in the form annexed hereto as Appendix A or in such other form as shall
be approved by the Board from time to time. The notice shall be accompanied by payment of the full Award Exercise Price as provided in the Award Agreement. 

  

	 	(c)	As a condition for the exercise of the Award, the Israeli Participant shall pay, or otherwise make arrangements to the Company’s satisfaction, for the payment of the tax and other obligatory payments applicable to
him (including all sums payable arising out of or in connection with the Company’s obligation to deduct tax and other obligatory payments at source) pursuant to applicable law and the provisions of the Plan and the Sub-Plan. 

  

	 	(d)	Upon receipt of all the requisite documents, approvals and payments from the Israeli Participant, including sufficient proof of payment or other arrangement with respect to the payment of any applicable taxes in form
satisfactory to the Company and the Trustee, the Trustee shall deliver a notice to the Company in the form annexed hereto as Appendix B or in such other form as shall be approved by the Board, whereupon the Company shall allot the shares in the name
of the Trustee. 

  

	 	(e)	 An Israeli Participant who desires to exercise an Award granted directly to him or her (and not through the
Trustee), subject to the approval of the Board, shall so notify the Company in writing in such form as shall be prescribed by the Board from time to time. As a condition for the exercise of the Award, the Israeli Participant shall pay or otherwise
make arrangements, to the Company’s or its Affiliate’s satisfaction, for the payment of the tax and other obligatory payments applicable to him (including all sums 

  
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payable by the Company or its Affiliate arising out of its obligation to deduct tax and other obligatory payments at source) pursuant to applicable law and the provisions of the Plan or the Sub-Plan. Upon receipt of all the requisite documents, approvals and payments from the Israeli Participant, including sufficient proof of payment or other arrangement with respect to the payment of any applicable
taxes in form satisfactory to the Company or the Affiliate, the Company shall allot the shares or the Award in the name of the Israeli Participant. 

  

	 	(f)	Without limiting the foregoing, the Board may, with the consent of the Israeli Participant, from time to time cancel all or any portion of any Award then subject to exercise, and the Company’s obligation in respect
of such Award may be discharged by: (i) payment to the Israeli Participant or to the Trustee on behalf of the Israeli Participant of an amount in cash equal to the excess, if any, of the Fair Market Value (as such term is defined in the Plan)
of the Awards at the date of such cancellation subject to the portion of the Award so canceled over the aggregate Award Exercise Price of such shares; (ii) the issuance or transfer to the Israeli Participant or to the Trustee on behalf of the
Israeli Participant of shares of the Company with a Fair Market Value at the date of such transfer equal to any such excess; or (iii) a combination of cash and shares with a combined value equal to any such excess, all as determined by the
Board in its sole discretion. 

  

	7.	ADDITIONAL DOCUMENTS 

 Whether the Award is granted or issued in the name of the Trustee
or otherwise, the Company shall have the right to demand from the Israeli Participant at any time that the same shall provide, and the Israeli Participant shall provide, any certificate, declaration or other document which the Company and/or the
Trustee shall consider to be necessary or desirable pursuant to Section 102. 
  

	8.	TAXATION 

  

	 	(a)	General 

 Subject to applicable law, the Israeli Participant shall be liable for all
taxes, duties, fines and other payments which may be imposed by the tax authorities (whether in Israel or abroad) and for every obligatory payment of whatever source in respect of the Awards, the shares (including, without limitation, upon the grant
of Awards, the exercise of the Awards, the sale of the shares or the registration of the shares in the Israeli Participant’s name) or dividends or any other benefit in respect thereof and/or for all charges which shall accrue to the Israeli
Participant, the Company, any Affiliate and/or to the Trustee in connection with the Plan, the Awards and/or the shares, or any act or omission of the Israeli Participant or the Company in connection therewith or pursuant to any determination of the
applicable tax or other authorities. 
  

	 	(b)	Deduction at Source 

 The Company (including any Affiliate) and/or the Trustee shall have
the right to withhold or require the Israeli Participant to pay an amount in cash or to retain or sell without notice Common Stock or any portion of the Award in value sufficient to cover any tax or obligatory payment required by a governmental
entity administrative authority to be withheld or otherwise deducted and paid with respect to the Awards or the shares subject thereto (including, without limitation, upon the registration of the shares in the Israeli Participant’s name) or
with respect to dividends or any other benefits in respect thereof (“Withholding Tax”), and to make payment (or to reimburse itself or himself for payment made) to the appropriate tax or other authority of an amount in cash equal to
the amount of such Withholding Tax. Notwithstanding the foregoing, the Israeli Participant shall be entitled to satisfy the obligation to pay any Withholding Tax, in whole or in part, by providing the Company and/or its Affiliate and/or the Trustee
with funds sufficient to enable the Company and/or its Affiliate and/or the Trustee to pay such Withholding Tax. 

  
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	 	(c)	Certificate of Authorization of Assessing Officer 

 The Company (including any Affiliate)
or the Trustee shall at any time be entitled to apply to the assessing officer, and in the case of an Israeli Participant abroad, to any foreign tax authority, for receipt of their certificate of authorization as to the amount of tax which the
Company or any Affiliate or the Israeli Participant or the Trustee is to pay to the tax authorities resulting from granting the Awards or allotting the shares, or regarding any other question with respect to the application of the Plan. 

 

	9.	RIGHTS AND/OR BENEFITS ARISING OUT OF THE EMPLOYEE/ EMPLOYER OR OTHER RELATIONSHIP AND THE ABSENCE OF AN OBLIGATION TO ENGAGE 

 

	 	(a)	Other than with respect to social security payments if required to be made by the Company or an Affiliate as a result of its choice of the tax treatment of the Awards pursuant to Section 102, no income or gain
which shall be credited to or which purports to be credited to the Israeli Participant as a result of the Sub-Plan, shall in any manner be taken into account in the calculation of the basis of the Israeli
Participant’s entitlements from the Company or any Affiliate or in the calculation of any social welfare right or other rights or benefits arising out of the employee/employer relationship between the parties or any other engagement by the
Company of the Israeli Participant. If, pursuant to any law, the Company or any Affiliate shall be obliged for the purposes of calculation of the said items to take into account income or gain actually or theoretically credited to the Israeli
Participant, the Israeli Participant shall indemnify the Company or any Affiliate, against any expense caused to it in this regard. 

  

	 	(b)	Nothing in the Sub-Plan shall be interpreted as obliging the Company or any Affiliate to employ or otherwise engage the Israeli Participant and nothing in the Sub-Plan or any Award granted pursuant thereto shall confer upon any Israeli Participant any right to continue in the employment (or other engagement or appointment, as applicable) of the Company or any Affiliate or
restrict the right of the Company or any Affiliate to terminate such employment (or other engagement or appointment, as applicable) at any time. The Israeli Participant shall have no claim whatsoever against the Company or any Affiliate as a result
of the termination of his or her employment (or other engagement or appointment, as applicable), including, without limitation, any claim that such termination causes any Awards to expire or otherwise terminate and/or prevents the Israeli
Participant from exercising the Awards and/or from receiving or retaining any shares pursuant to any agreement between him and the Company, or results in any loss due to an early imposition, or earlier than anticipated imposition, of tax or other
liability pursuant to applicable law. 

  

	10.	TERM, TERMINATION AND AMENDMENT 

 This Sub-Plan
shall become effective as of the Effective Date and shall terminate on upon the termination of the Plan. 
  

	11.	RELEASE OF THE TRUSTEE FROM LIABILITY AND INDEMNIFICATION 

  

	 	(a)	 In no event shall the Trustee be liable to the Company and/or any Israeli Participant under the Sub-Plan and/or any third party (including without prejudice to the generality of the aforegoing, to the income tax authorities and any other governmental or administrative authority), or to a purchaser of shares
from any Israeli Participant with respect to any act or omission which has been or will be carried out in relation to the Sub-Plan, its execution and any matter connected thereto or arising therefrom. The
Company will not, and the Israeli 

  
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Participant will be required to covenant upon signing the Award Agreement that he will not, make any claim against the Trustee in any manner whatsoever and on any ground whatsoever and they
expressly agree that if the Trustee is sued by them, then the Trustee shall be entitled by virtue of this Section alone to apply to the court for dismissal of the action against them with costs. The Company covenants and agrees that if an action is
commenced by any third party against the Trustee it shall be entitled, without any objection on the Company’s part to join the Company as a third party to any action and a judgment against them will be paid by the Company. 

 

	 	(b)	The Company covenants and the Israeli Participant will be required to covenant to indemnify the Trustee against any liability in relation to any claim and/or demand made against the Trustee by any person whatsoever,
including the tax authorities, in relation to its acts or omissions in connection with the Plan. 

  

	12.	GOVERNING LAW 

 The Sub-Plan (including any
relevant portion of the Plan) and all instruments issued thereunder shall be governed by and construed in accordance with the laws of the State of Israel. 

  
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 ELOXX PHARMACEUTICALS INC. 

APPENDIX A 

to Eloxx Pharmaceuticals Inc. Israeli Sub-Plan 

(SECTION 11.3) 

NOTICE OF EXERCISE 

[Adjustments may be required for Awards that are not options] 

Date:                      

The Trustee under the Eloxx Pharmaceuticals, Inc. 2018 Equity Incentive Plan and its Israeli Sub-Plan 

Dear Sirs, 
 RE:
NOTICE OF EXERCISE 
 I hereby wish to inform you that it is my desire that of the
Award which was granted to you on              to acquire             
(            ) Common Stock of Eloxx Pharmaceuticals Inc. (the “Company”) on my behalf, you exercise and acquire on my behalf
             (            ) of the Common Stock subject to the said Award at a price of USD
             per share, all in accordance with the Plan and Sub-Plan. 

Attached to this Notice is a check in the amount of USD              (USD
            ), as payment for the above mentioned shares. 
 I am aware that all the shares
shall be allotted to you, registered in your name and that you shall hold all share certificates representing such shares. 
 Likewise, I am aware of and
agree to all other provisions of the Plan, the Sub-Plan and applicable law. 
  

	
	Yours sincerely,
	
	  

	Signature
	
	  

	Name

  
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 ELOXX PHARMACEUTICALS INC. 

APPENDIX B 

to Eloxx Pharmaceuticals Inc. Israeli Sub-Plan 

(SECTION 11.5) 

NOTICE OF EXERCISE 

[Adjustments may be required for Awards that are not options] 

Date:                      

Dear Sirs, 
 RE:
NOTICE OF EXERCISE 
 Please be advised that I hereby exercise
                     (                    ) of
the Common Stock subject to the Award which was granted to me on behalf of                      on
                         to acquire
                     (                    )
Common Stock of Eloxx Pharmaceuticals Inc., at a price of USD                      per share, all in accordance with the Plan and Sub-Plan. 
 Attached to this Notice is a check in the amount of USD
                     (USD                     )
as payment for the abovementioned shares. 
  

	
	Yours sincerely,
	
	         

	The Trustee

  
 10EX-10.4

 Exhibit 10.4 

102 CAPITAL GAINS OPTION AGREEMENT 

THIS 102 CAPITAL GAINS OPTION AGREEMENT (this “Agreement”) is made and entered into as of February
    , 2018, by and between Eloxx Pharmaceuticals Inc., a Corporation registered under the laws of the State of Delaware (the “Corporation”) and
[                ] (the “Grantee”) (the Corporation and the Grantee shall sometimes be referred to, each as a “Party” and collectively,
as the “Parties”). 
  

	WHEREAS:	The Grantee is an employee of the Corporation and/or a Related Company; and 

  

	WHEREAS:	The Corporation desires to grant the Grantee options to purchase shares in the Corporation and the Grantee is interested in receiving the aforesaid options, all in accordance with and subject to the Corporation’s
Share Ownership and Option Plan (2013), as shall be amended from time to time, and the annexes thereto (the “Plan”) and the provisions of this Agreement, and their intention is that the provisions of the Ordinance, Section 102
and the Rules shall apply to the options granted and shares issued; and 

  

	WHEREAS:	The Grantee has read Section 102, the Rules and the Plan, wishes to be bound by them and desires that they apply to the options and shares which shall be granted to her hereunder; 

NOW, THEREFORE, it is agreed as follows: 
  

	1.	Application of the Provisions of the Plan and the Ordinance 

  

	1.1.	The Grantee hereby confirms that she has carefully read the Plan and that she acknowledges and agrees to all of the provisions, conditions, limitations, authorizations, declarations and commitments included therein,
except and to the extent otherwise expressly provided herein. 

  

	1.2.	All of the provisions, conditions, limitations and declarations included and specified in the Plan are hereby incorporated herein by reference and constitute an integral part of this Agreement and of the Grantee’s
undertakings and obligations hereunder. Except and to the extent otherwise expressly provided herein, nothing in this Agreement or in the provisions hereof shall derogate from anything contained in the Plan. 

 

	1.3.	The Grantee acknowledges, agrees and confirms that the Plan may be amended from time to time as provided for therein. The Grantee understands that any amendment to the Plan or any document connected to the Plan, shall
bind her as if she was a party thereto, provided, that, except as otherwise provided for herein or in the Plan, no amendment or modification of the Plan may, without the consent of the Grantee, adversely affect the rights of the
Grantee hereunder. 

  

	1.4.	The Grantee declares, covenants and agrees that the Ordinance, Section 102 and the Rules, as the same shall be amended from time to time, including the trust agreement between the Corporation and the Trustee (the
conditions whereof are accepted by the Grantee and upon signing this Agreement she approves them as an integral part of this Agreement) and the notice to the Tax Assessing Officer about the allotment, are fully binding on the Grantee and,
notwithstanding the provisions of Section 1.3 above, shall prevail in case of contradiction over any other provision in this Agreement or in the Plan. 

  

	1.5.	A copy of the Plan is attached hereto as Exhibit A and constitutes an integral part hereof. 

  
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	2.	Grant of Option; Vesting 

  

	2.1.	Subject to this Agreement and the Plan, the Corporation shall grant to the Trustee for the benefit of the Grantee, a CGO Approved 102 Option (the “Option”) to purchase
[        ] (                    ) Shares of Common Stock of the Corporation, par value $0.01 each (the
“Shares”), at an exercise price equal to [            ], at the time and in the manner hereinafter provided. 

 

	2.2.	The Option Exercise Price shall be paid on the date of the exercise thereof. 

  

	2.3.	The term of the Option shall be ten (10) years from the date hereof or such shorter period as is prescribed herein or in the Plan (the “Term”). 

 

	2.4.	The Option may be exercised during the Term, in whole or in part, by the Trustee in favor of the Grantee, pursuant to the Grantee’s instructions. 

The Option shall vest as follows: 

[                       
                                         
                    ]. 
 The
consideration shall be paid on the date of the exercise of the Option. The Option shall be exercisable by the Trustee on behalf of the Grantee in progressive stages on the exercise dates as aforesaid, provided, that the Grantee shall
have been continuously engaged with the Corporation and/or a Related Company, from the date hereof until each such date of exercise. 
  

	2.5.	In the event that the Grantee’s engagement with the Corporation is terminated, then the provisions of Section 9.6 of the Plan shall apply. 

 

	2.6.	A Grantee who desires that the Trustee exercise the Option granted to the Trustee on his behalf shall so instruct the Trustee in writing in the form attached hereto as Exhibit B or in such other form as
shall be approved by the Board from time to time. The notice shall be accompanied by payment of the full Option Exercise Price. A certificate for the purchased Shares shall be issued in the name of the Trustee for the benefit of the Grantee and
according to applicable law may bear a restrictive legend. 

  

	3.	Non Assignability; Restriction Period 

  

	3.1.	All of the Grantee’s rights hereunder, including without limitation, the Grantee’s rights to (a) receive and exercise the Option; (b) receive all or part of the Shares; (c) require that the same
shall be registered in her name; (d) request that the Trustee sell all or part of the Shares on her behalf, are personal and except insofar as is specified in this Agreement and/or in the Plan, and, where applicable, subject to Section 102
and the Rules, may not be transferred, assigned, pledged, withheld, attached or otherwise charged either voluntarily or pursuant to any law, except by way of transfer pursuant to the laws of inheritance or as otherwise determined by the Board, and
no power of attorney or deed of transfer, whether the same has immediate effect or shall take effect on a future date, shall be given with respect thereto. During the lifetime of the Grantee the Option may only be exercised by the designated Grantee
or, if granted to the Trustee, by the Trustee on behalf of the designated Grantee. 

  

	3.2.	 Without derogating from any provision contained herein, the Grantee declares and agrees that she is restricted
from making any disposition of the Option or the Shares for a period of at least twenty-four (24) months from the end of the tax year in which the 

  
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Options are allocated to the Trustee or a shorter period as approved by the tax authorities. The Grantee acknowledges and understands that the meaning of the above restriction for purposes of the
tax authorities is that if the Grantee voluntarily sells (in accordance with the meaning of Section 102 and the Rules) the Option or the Shares before the end of the Restriction Period, the Option or the Shares shall be subject to tax as
ordinary income as per Sections 2(1) and 2(2) of the Ordinance and the other provisions of Section 102 and the Rules. Furthermore, all rights related to the Option or the Shares will be held by the Trustee until the end of the Restriction
Period, including, without limitation, bonus shares, and will be subject to the provisions of Section 102 and the Rules. 

  

	3.3.	Notwithstanding the above, if any such sale or transfer occurs during the Restriction Period, the sanctions under Section 102 and under the Rules or regulation or orders or procedures promulgated thereunder shall
apply to and shall be borne by the Grantee. 

  

	4.	Grantee Representations, Warranties and Covenants 

 Without derogating in any manner from the
provisions of the Plan or this Agreement, the Grantee hereby represents, warrants, agrees and undertakes as follows: 
  

	4.1.	The Grantee acknowledges that the grant of the Option, the exercise thereof, the issuance of the Shares, the execution of this Agreement and the Grantee’s participation in the Plan shall have tax consequences to
the Grantee, and that the Corporation is not able to ensure or represent to the Grantee the nature and extent of such tax consequences. 

  

	4.2.	The Grantee acknowledges that nothing in this Agreement and/or in the Plan shall be interpreted as a commitment and/or an agreement by the Corporation and/or any Related Company to engage with the Grantee, whether for a
certain period or otherwise. The Grantee shall have no claim whatsoever against the Corporation and/or any Related Company (including, without limitation, any of its or their officers, directors or shareholders) with respect to the termination of
her engagement, even if such termination causes the Option or any other options, in whole or in part, to expire and/or prevents her from exercising the Option in whole or in part and/or from receiving or retaining the Shares, or results in any loss
due to any imposition of tax liability (including any early imposition) pursuant to applicable law. 

  

	4.3.	The Grantee acknowledges and agrees that no income or gain which the Grantee may be credited with or which purports to be credited to the Grantee as a result of the grant of the Option, the issue of the Shares, the
transfer into the Grantee’s name thereof or the sale thereof, if any, shall in any manner be taken into account in the calculation of the basis for the Grantee’s entitlements from the Corporation or any Related Company or in the
calculation of any social welfare right or other rights or benefits arising out of the employee/employer relationship, including without limitation, social security, manager’s insurance, educational fund, pension funds, severance pay, holiday
pay, etc. 

 In the event that the Corporation and/or any Related Company shall be required, pursuant to any law, to take into
account for purposes of calculating any such benefits, any of the aforesaid elements of income or gain actually or theoretically credited to the Grantee, the Grantee shall promptly indemnify the Corporation and/or any Related Company against any
liability or expense caused to it in this regard, and any such amount shall be deemed a debt of the Grantee to the Corporation and/or any Related Company, which may be deducted or set off from any amounts payable to the Grantee, subject to
applicable law. 
  

	4.4.	The Grantee acknowledges that she is aware of, and clearly understands: (a) the rights and limitations attached to the Shares as set forth in the Plan and this Agreement; and (b) the limitations on
transferability thereof set forth in the Plan, and this Agreement. 

  
 3 

	4.5.	The Grantee shall have none of the rights of a shareholder of the Corporation, for as long as the Option has not been exercised and, once exercised, for as long as the Shares have not been transferred and registered in
the Grantee’s name. 

  

	4.6.	The Grantee has full knowledge of the Corporation and its activities, and is aware that the Corporation operates in a sophisticated, high tech and high risk sector, and that the market thereof is restricted and highly
competitive, and that the exercise of the Option constitutes an economic risk. The Grantee undertakes that she shall not have any claim against the Corporation and/or any Related Corporation or any of its or their officers, directors, Grantees,
shareholders or advisors if the Grantee’s investment in the Shares shall fail or for the payment of any tax due or for any other reason. 

  

	4.7.	The exercise of this Option and the issuance of the Shares upon such exercise shall be subject to compliance by the Corporation and Grantee with all applicable requirements of law relating thereto and with all
applicable regulations of any stock exchange (or the Nasdaq National Market, if applicable) on which the Common Stock may be listed for trading at the time of such exercise and issuance. 

 

	4.8.	The inability of the Corporation to obtain approval from any regulatory body having authority deemed by the Corporation to be necessary to the lawful issuance and sale of any Common Stock pursuant to this Option shall
relieve the Corporation of any liability with respect to the non-issuance or sale of the Common Stock as to which such approval shall not have been obtained. The Corporation, however, shall use its best
efforts to obtain all such approvals. 

  

	5.	Taxes; Indemnification of the Corporation, the Trustee  

  

	5.1.	Without derogating from the provisions of the Plan, the Grantee hereby covenants, whether or not the provisions of the Ordinance, Section 102 or the Rules shall apply, to bear all tax obligations, duties, levies,
fines and other payments which may be imposed by the tax authorities (whether in Israel or abroad) and any other obligation or expense from whatever source, including but not limited to, every obligatory payment of whatever source in respect of or
arising out of the Plan (including granting of the Option, exercise of the Option, issue of the Shares, transfer of the Shares into the Grantee’s name and the sale thereof by the Grantee and/or by the Trustee) or dividends or any other benefit
in respect thereof, and/or all other charges which may accrue to the Grantee, the Corporation, any Related Company and/or the Trustee in connection with the Plan, the Options and/or the Shares, or any act or omission of the Grantee or the
Corporation or a Related Company in connection therewith or pursuant to any determination of the applicable tax or other authorities. 

Without derogating from the generality of the aforesaid and subject to applicable law, the Grantee’s obligations in this regard shall
include income tax, stamp tax, employer’s tax, capital gains tax, social security insurance and any other tax, levy or payment which the Grantee or the Corporation and/or any Related Company is or shall be obliged to pay in connection with the
Option and/or the Shares (including deductions at source which the Corporation is obliged to make for tax imposed upon the Grantee) and the Grantee shall indemnify the Corporation and/or any Related Company and/or the Trustee for every charge or
payment as aforesaid, which may be deducted or set off 

  
 4 

 
from any amounts payable to the Grantee, including, without limitation, dividends, consideration for the sale of shares or from any other source, at the Corporation and/or Related Company’s
sole and absolute discretion, subject to applicable law. 
  

	5.2.	Without derogating from the above, the Grantee hereby covenants to pay the Corporation and/or the Trustee promptly upon their first request, any sum for which they are responsible (or, in the Board’s opinion, they
might be responsible for), and which is payable by the Grantee as set forth in Section 5.1 hereof to the income tax authorities and/or any other governmental or administrative authority, whether in Israel or abroad (including for deduction of
tax at source) pursuant to the Plan and/or in respect of the Grantee’s participation in the Plan, whether the Corporation and/or the Trustee’s responsibility as aforesaid shall arise directly or in respect of any responsibility of the
Grantee for such payment. The Grantee covenants to promptly indemnify the Corporation and/or any Related Company and/or the Trustee for any charge or payment as aforesaid, which may be deducted or set off from any amounts payable to the Grantee.

  

	5.3.	Furthermore, the Grantee acknowledges that the Grantee shall not have, and the Grantee hereby waives, any complaint and/or cause of action the same has or shall have in the future against the Trustee and/or against the
Corporation in any way connected to any taxation resulting from the grant of the Option, the exercise thereof, the transfer of Shares into the Grantee’s name, the sale of Shares by the Grantee and/or by the Trustee and/or any other matter which
is in any manner whatsoever connected to the Option, the Shares and/or the participation of the Grantee in the Plan. 

  

	5.4.	In no event shall the Trustee be liable to the Corporation and/or the Grantee and/or to any third party (including, without derogating from the generality of the aforesaid, the income tax authorities and any other
governmental or administrative authority, whether in Israel or abroad) or a purchaser of Shares from the Grantee (or the Trustee), with respect to any act which has been or which shall be carried out in relation to the Plan and any matter connected
thereto or arising therefrom. The Corporation and/or any Related Company and the Grantee covenant, upon signing this Agreement, that they will not make, and they each hereby waive, any and all claims against the Trustee as aforesaid and each of the
Corporation, Related Company and the Grantee expressly agree that if either shall make any claim against the Trustee the same shall then be entitled on the grounds of this section alone to apply to the competent court for dismissal of the action
against them, with costs. The Corporation covenants and agrees that if a claim is brought by any third party against the Trustee the same will be entitled without objection by the Corporation, to join the Corporation as a third party to any such
action and any judgment against them shall be paid by the Corporation. 

 The Corporation and the Grantee hereby covenant to
indemnify the Trustee against any liability in relation to any claim and/or demand made against the Trustee by any person whatsoever, including the tax authorities, in relation to their acts or omissions in connection with the Plan. 

The provisions of this section and the other provisions of this Agreement and the Plan which grant any right, power, immunity or any authority
to the Trustee shall operate in favor of the Trustee and the Trustee shall be entitled to act pursuant to and enforce such provisions, and the Corporation and the Grantee shall be liable to the Trustee as if the Trustee was party to this Agreement.

  

	6.	Miscellaneous 

  

	6.1.	 Preamble; Interpretation. The preamble to this Agreement is the basis and constitutes an integral part
thereof. All article and section headings herein are inserted for convenience 

  
 5 

	 	
only and shall not modify or affect the construction or interpretation of any provision of this Agreement. Unless the context otherwise requires, capitalized terms not otherwise defined herein
shall bear the meanings ascribed to them in the Plan. 

  

	6.2.	Entire Agreement; Amendment. The Grantee declares and agrees that this Agreement and the Plan prevail over any previous agreement, arrangement and/or understanding, whether written or oral, between the Grantee
and the Corporation and/or any Related Company, or the officers and/or directors and/or the shareholders thereof with respect to the subject matters hereof and thereof and that any agreement, arrangement and/or understanding as aforesaid are null
and void and of no further force or effect. Subject to the provisions of this Agreement and the Plan, no modification or amendment of this Agreement will be valid unless executed by the Corporation and the Grantee. 

 

	6.3.	Confidentiality. The Grantee shall regard the information in this Agreement and its exhibits attached hereto as confidential information and the Grantee shall not reveal its contents to anyone except when
required by law or for the purpose of gaining legal or tax advice. The Grantee specifically acknowledges and understands that the Corporation is a public company traded on the OTC market. Accordingly, (a) any confidential information of the
Corporation may be considered as “inside information” pursuant to U.S. securities laws and regulations; and (b) the Corporation is required to make certain disclosures and publications under applicable laws which may include this
Agreement. 

  

	6.4.	Disputes; Governing Laws. This Agreement shall be governed by and construed in accordance with the laws of the State of Israel and, subject to the provisions below, the competent courts in the Tel-Aviv district shall have exclusive jurisdiction with respect to any matter or conflict with respect thereto. 

As a condition of the granting of the Option, the Grantee and the Grantee’s successors and assigns agree that any dispute or disagreement
which shall arise under or as a result of this Agreement shall be determined by the Board, or any committee designated by the Board pursuant to the Plan, in its sole discretion and judgment and that any such determination and any interpretation by
the Board or any such committee of the terms of this Agreement shall be final and shall be binding and conclusive for all purposes. In making any such determination or interpretation the Board or any such committee shall not be bound by the rules of
procedure or evidence or substantive law and shall not be required to give any reasons therefore. 
  

	6.5.	Notices and/or Instructions. Every notice and/or instruction required or permitted to be given pursuant to this Agreement shall be given in writing and shall be deemed to have been delivered (i) on the date
of its delivery to the addressee by hand, (ii) three (3) days after having been sent by registered mail or (iii) one (1) after having been sent by facsimile. The parties’ addresses for the purpose of this Section shall be as
communicated by each Party to the other by written notice in advance. 

 A stamp or a receipt on behalf of the postal service
which evidences the time of delivery of the notice or a confirmation of transmission shall constitute conclusive evidence as to the date of delivery and no party shall claim that a notice delivered as aforesaid has not been received by such party.

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 6 

 [Signature Page to Eloxx Pharmaceuticals Inc. Option Agreement] 

IN WITNESS WHEREOF, the parties hereto have executed this Option Agreement as of the date written hereinabove. 

 

			
	  

ELOXX PHARMACEUTICALS INC.
	  	  

GRANTEE

		
	 By:
                                         
                           
	  	

  
 7 

 Exhibit A 

The Plan 

  
 8 

 Exhibit B 

NOTICE OF EXERCISE 
 Date:
                     
 The Trustee under the Eloxx
Pharmaceuticals Inc. Employee Share Ownership and Option Plan (2013) (the “Plan”) 
 Dear Sirs or Madams, 

Re: Notice of Exercise 
 I hereby
wish to inform you that it is my desire that of the Option which was granted to you on                  to acquire
             (                ) Shares of Common Stock of Eloxx Pharmaceuticals Inc. (the
“Corporation”) on my behalf, you exercise and acquire on my behalf                 
(                ) of the Shares of Common Stock subject to the said Option at a price of USD             
per share, all in accordance with the Plan. 
 Attached to this Notice is a check in the amount of USD
                 (USD                 ), as payment for the above mentioned Shares. 

I am aware that all the shares shall be allotted to you, registered in your name and that you shall hold all share certificates representing such shares. 

Likewise, I am aware of and agree to all other provisions of the Plan and applicable law. 

 

	
	Yours sincerely,
	
	  
 Signature

	
	  
 Name

  
 9

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