Document:

Employment Agreement between John J. Sliter and Panther II Transportation, Inc.

 Exhibit 10.5 
 

 
 AGREEMENT 
 AGREEMENT by and between Panther II Transportation, Inc. (the “Company”), an Ohio corporation with its principal place of business at Seville, Ohio, and John J. Sliter, of Medina, Ohio (the “Executive”), effective as of
the 27th day of July, 2005. 
 WHEREAS, the operations of the Company and its Affiliates are a complex matter requiring direction and
leadership in a variety of arenas, including financial, strategic planning, regulatory, safety, owner-operator relationships and recruitment, community relations and others; 
 WHEREAS, the Executive is possessed of certain experience and expertise that qualify him to provide the direction and leadership required by the Company
and its Affiliates; and 
 WHEREAS, subject to the terms and conditions hereinafter set forth, the Company therefore wishes to employ the
Executive as its Chief Financial Officer and the Executive wishes to accept such employment; 
 NOW, THEREFORE, in consideration of the
foregoing premises and the mutual promises, terms, provisions and conditions set forth in this Agreement, the parties hereby agree: 
 1.
Employment. Subject to the terms and conditions set forth in this Agreement, the Company hereby offers and the Executive hereby accepts employment. 
 2. Term. Subject to earlier termination as hereafter provided, the Executive’s employment hereunder shall be for a term of three (3) years, commencing on the effective date hereof, and shall be
automatically extended thereafter for successive terms of one year each, unless either party provides notice to the other at least ninety (90) days prior to the expiration of the original or any extension term that the Agreement is not to be
extended. The term of this Agreement, as from time to time extended or renewed, is hereafter referred to as “the term of this Agreement” or “the term hereof.” 
 3. Capacity and Performance. 
 (a)
During the term hereof, the Executive shall serve the Company as its Chief Financial Officer. 
 (b) During the term hereof, the Executive
shall be employed by the Company on a full-time basis and shall perform such duties and responsibilities on behalf of the Company and its Affiliates as may be designated from time to time by the Board or by its designees. 
 (c) During the term hereof, the Executive shall devote his full business time and his best efforts, business judgment, skill and knowledge exclusively to
the advancement of the business and interests of the Company and its Affiliates and to the discharge of his duties and responsibilities hereunder. The Executive shall not engage in any other business activity or serve 

 in any industry, trade, professional, governmental or academic position during the term of this Agreement, except
(i) as may be expressly approved in advance by the Board in writing or (ii) for such activities or services as are being conducted by the Executive as of the date hereof which are described in clause (ii) of Section 8
(a) hereof 
 4. Compensation and Benefits. As compensation for all services performed by the Executive under and during the term
hereof and subject to performance of the Executive’s duties and of the obligations of the Executive to the Company and its Affiliates, pursuant to this Agreement or otherwise: 
 (a) Base Salary. During the term hereof, the Company shall pay the Executive a base salary at the rate of One Hundred Nine Thousand Two Hundred
Dollars ($109,200) per annum, payable in accordance with the payroll practices of the Company for its executives and subject to annual adjustment by the Board, in its sole discretion. Such base salary, as from time to time increased, is hereafter
referred to as the “Base Salary”. 
 (b) Incentive & Bonus Compensation. Beginning in fiscal year 2006, if an
incentive or bonus compensation program is made available to executives of the Company generally and the Executive is not then covered by any incentive or bonus compensation program, the Executive shall be entitled during the term hereof to
participate in such program in accordance with the terms thereof, as such terms may be modified or amended by the Company from time to time; provided, however, that nothing contained herein shall obligate the Company to adopt or continue such an
incentive or bonus compensation program. Any compensation paid to the Executive under such an incentive or bonus compensation program shall be in addition to the Base Salary. For fiscal year 2005, the Executive shall be eligible to receive a bonus
in accordance with the terms set forth on Schedule A hereto. 
 (c) Stock Options. The Executive shall be eligible to participate in
the Company’s 2005 Stock Option Plan in accordance with the terms thereof, as such terms may be modified or amended by the Company from time to time in its sole discretion (the “Stock Option Plan”). On or about the date hereof, the
Company shall grant to the Executive, pursuant to the Stock Option Plan, an option to purchase 23,823.53 shares of the common stock of the Company at a price of $10.00 per share (the “Option”). The Option and the shares which are subject
to the Option shall be subject to a stockholders agreement, a stock option agreement, the Stock Option Plan and such other restrictions as are generally applicable to stock options issued to employees of the Company, as each may be modified or
amended from time to time. 
 (d) Vacations. During the term hereof, the Executive shall be entitled to three (3) weeks of
vacation per calendar year, to be taken at such times and intervals as shall be determined by the Executive, subject to the reasonable business needs of the Company. Any unused vacation at the end of any calendar year shall be forfeited. 

(e) Other Benefits. During the term hereof and subject to any contribution therefore generally required executives of the Company, the
Executive shall be entitled to participate in any and all employee benefit plans from time to time in effect for executives of the Company generally, except to the extent such plans are in a category of benefit otherwise provided to the Executive
(e.g., severance pay). Such participation shall be subject to the terms of the applicable plan documents and generally applicable Company policies. Without limiting the foregoing, for fiscal year 2005, the Executive shall be entitled to
receive the allowances 

 described on Schedule B hereto. The Company may alter, modify, add to or delete its employee benefit plans at any time as
it, in its sole judgment, determines to be appropriate, without recourse by the Executive. 
 (f) Business Expenses. The Company shall
pay or reimburse the Executive for all reasonable, customary and necessary business expenses incurred or paid by the Executive in the performance of his duties and responsibilities hereunder, subject to any maximum annual limit and other
restrictions on such expenses set by the Board and to such reasonable substantiation and documentation as may be specified by the Company from time to time. 
 5. Termination of Employment and Severance Benefits. Notwithstanding the provisions of Section 2 hereof, the Executive’s employment hereunder shall terminate prior to the expiration of the term under
the following circumstances: 
 (a) Death In the event of the Executive’s death during the term hereof, the Executive’s
employment hereunder shall immediately and automatically terminate. In such event, the Company shall pay to the Executive’s designated beneficiary or, if no beneficiary has been designated by the Executive, to his estate, (i) the Base
Salary earned but not paid through the date of termination, (ii) any vacation time earned but not used through the date of termination, (iii) any bonus compensation awarded but unpaid on the date of termination, and (iv) any business
expenses incurred by the Executive but un-reimbursed on the date of termination, provided that such expenses and required substantiation and documentation are submitted within thirty (30) days of termination and that such expenses are
reimbursable under Company policy (all of the foregoing, “Final Compensation”). The Company shall have no further obligation to the Executive hereunder. 
 (b) Disability. 
 (i) The Company may terminate the Executive’s employment
hereunder, upon notice to the Executive, in the event that the Executive becomes disabled during his employment hereunder through any illness, injury, accident or condition of either a physical or psychological nature and, as a result, is unable to
perform substantially all of his duties and responsibilities hereunder, notwithstanding the provision of any reasonable accommodation, for ninety (90) days during any period of three hundred and sixty-five (365) consecutive calendar days.
In the event of such termination, the Company shall have no further obligation to the Executive, other than for payment of Final Compensation. 
 (ii) The Board may designate another employee to act in the Executive’s place during any period of the Executive’s disability. Notwithstanding any such designation, the Executive shall continue to receive
the Base Salary in accordance with Section 4(a) and benefits in accordance with Section 4(e), to the extent permitted by the then-current terms of the applicable benefit plans, until the Executive becomes eligible for disability income
benefits under the Company’s disability income plan or until the termination of his employment, whichever shall first occur. 
 (iii) While receiving disability income payments under the Company’s disability income plan, the Executive shall not be entitled to receive any Base Salary under Section 4(a) hereof, but shall continue to participate in Company
benefit plans in accordance with Section 4(e) and the terms of such plans, until the termination of his employment. 

 (iv) If any question shall arise as to whether during any period the Executive is
disabled through any illness, injury, accident or condition of either a physical or psychological nature so as to be unable to perform substantially all of his duties and responsibilities hereunder, the Executive may, and at the request of the
Company shall, submit to a medical examination by a physician selected by the Company to whom the Executive or his duly appointed guardian, if any, has no reasonable objection to determine whether the Executive is so disabled and such determination
shall for the purposes of this Agreement be conclusive of the issue. If such question shall arise and the Executive shall fail to submit to such medical examination, the Company’s determination of the issue shall be binding on the Executive.

 (c) By the Company for Cause. The Company may terminate the Executive’s employment hereunder for Cause at any time upon notice
to the Executive setting forth in reasonable detail the nature of such Cause. The following, as determined by the Board in its reasonable judgment, shall constitute Cause for termination: 
 (i) the refusal or failure to perform (other than by reason of disability), or material negligence in the performance of the
Executive’s duties and responsibilities to the Company or any of its Affiliates, or refusal or failure to follow or carry out any direction of the Board; 
 (ii) the material breach by the Executive of any provision of this Agreement or any other agreement to which the Executive and the Company
or any of its Affiliates are party; 
 (iii) the commission of any felony, fraud, embezzlement, theft or other act involving
dishonesty or moral turpitude by the Executive; 
 (iv) the Executive’s abuse of drugs or alcohol while performing
services for the Company; or 
 (v) any other conduct that involves a breach of fiduciary obligation on the part of the
Executive or otherwise could reasonably be expected to have a material adverse effect upon the business, interests or reputation of the Company or any of its Affiliates. 
 Upon the giving of notice of termination of the Executive’s employment hereunder for Cause, the Company shall have no further obligation to the Executive, other than for Final Compensation. 
 (d) By the Company Other than for Cause. The Company may terminate the Executive’s employment hereunder other than for Cause at any time upon
notice to the Executive. In the event of such termination, in addition to Final Compensation and provided that no benefits are payable to the Executive under a separate severance agreement or an executive severance plan as a result of such
termination, then until the conclusion of a period of twelve (12) months following the date of termination (the “Severance Pay Period”), the Company shall continue to pay the Executive the Base Salary at the rate in effect on the date
of termination. In addition, if the Executive is enrolled in the Company’s medical and dental plans on the date of 

 termination and provided that the Executive is entitled to continue such participation under applicable law and plan
terms, if the Executive elects to continue his participation and that of his eligible dependents in those plans for a period of time under the federal law known as “COBRA,” then subject to any employee contribution applicable to active
employees generally, the Company shall continue to pay the cost of the Executive’s participation and that of his eligible dependents in such plans until the earlier of (i) the conclusion of the Severance Pay Period or (ii) the date
the Executive becomes eligible for medical and dental benefits from a subsequent employer. Any obligation of the Company to the Executive hereunder is conditioned, however, upon the Executive signing a release of claims in the form provided by the
Company (the “Employee Release”) within twenty-one days (or such greater period as the Company may specify) following the later of the date on which the Executive receives notice of termination of employment or the date the Executive
receives a copy of the Employee Release and upon the Executive not revoking the Employee Release in a timely manner thereafter. Base Salary to which the Executive is entitled hereunder shall be payable in accordance with the normal payroll practices
of the Company and will begin at the Company’s next regular payroll period which is at least five business days following the effective date of the Employee Release, but shall be retroactive to next business day following the date of
termination 
 (e) By the Executive The Executive may terminate his employment hereunder at any time upon sixty (60) days’
notice to the Company. In the event of termination of the Executive pursuant to this Section 5(e), the Board may elect to waive the period of notice, or any portion thereof, and, if the Board so elects, the Company will pay the Executive his
Base Salary for the notice period (or for any remaining portion of the period). The Company shall have no further obligation to the Executive, other than for any Final Compensation due to him. 
 (f) Post-Agreement Employment. In the event the Executive remains in the employ of the Company or any of its Affiliates following termination of
this Agreement, by the expiration of the term or otherwise, then such employment shall be at will. 
 6. Effect of Termination. The
provisions of this Section 6 shall apply to termination due to the expiration of the term hereof, and termination pursuant to Section 5 or otherwise. 
 (a) Payments by the Company of any Base Salary and contributions to the cost of the Executive’s continued participation in the Company’s group health and dental plans that may be due the Executive in each
case under the applicable termination provision of Section 5 shall constitute the entire obligation of the Company to the Executive. The Executive shall promptly give the Company notice of all facts necessary for the Company to determine the
amount and duration of its obligations in connection with any termination pursuant to Section 5(d) hereof. 
 (b) Except for medical and
dental plan coverage continued pursuant to Section 5(d) or 5(e) hereof, benefits shall terminate pursuant to the terms of the applicable benefit plans based on the date of termination of the Executive’s employment without regard to any
continuation of Base Salary or other payment to the Executive following such date of termination. 
 (c) Provisions of this Agreement shall
survive any termination if so provided herein or if necessary or desirable to accomplish the purposes of other surviving provisions, including without limitation the obligations of the Executive under Sections 7 and 8 hereof. The 

 obligation of the Company to make payments to or on behalf of the Executive under Section 5(d) or 5(e) hereof is
expressly conditioned upon the Executive’s continued full performance of obligations under Sections 7 and 8 hereof. The Executive recognizes that, except as expressly provided in Section 5(d) or 5(e), no compensation is earned after
termination of employment. 
 7. Confidential Information. 
 (a) The Executive acknowledges that the Company and its Affiliates continually develop Confidential Information, that the Executive may develop
Confidential Information for the Company or its Affiliates and that the Executive may learn of Confidential Information during the course of employment. The Executive will comply with the policies and procedures of the Company and its Affiliates for
protecting Confidential Information and shall not disclose to any Person or use, other than as required by applicable law or for the proper performance of his duties and responsibilities to the Company and its Affiliates, any Confidential
Information obtained by the Executive incident to his employment or other association with the Company or any of its Affiliates. The Executive understands that this restriction shall continue to apply after his employment terminates, regardless of
the reason for such termination. The obligations of confidentiality imposed by this Section 7(a) shall not apply to Confidential Information that otherwise becomes generally known to the public through no act of Executive in breach of this
Agreement or which is required to be disclosed by court order or applicable law. 
 (b) All documents, records, tapes and other media of
every kind and description relating to the business, present or otherwise, of the Company or its Affiliates and any copies, in whole or in part, thereof (the “Documents”), whether or not prepared by the Executive, shall be the sole and
exclusive property of the Company and its Affiliates. The Executive shall safeguard all Documents and shall surrender to the Company at the time his employment terminates, or at such earlier time or times as the Board or its designee may specify,
all Documents then in the Executive’s possession or control. 
 8. Restricted Activities The Executive agrees that some
restrictions on his activities during and after his employment are necessary to protect the goodwill, Confidential Information and other legitimate interests of the Company and its Affiliates: 
 (a) While the Executive is employed by the Company and for twelve (12) months after his employment terminates (in the aggregate, the
“Non-Competition Period”), the Executive shall not, directly or indirectly, whether as owner, partner, investor, consultant, agent, employee, co-venturer or otherwise, compete with the Company or any of its Affiliates within the
continental United States or undertake any planning for any business competitive with the Company or any of its Affiliates. Specifically, but without limiting the foregoing, the Executive agrees not to engage in any manner in any activity that is
directly or indirectly competitive or potentially competitive with the business of the Company or any of its Affiliates as conducted or under consideration at any time during the Executive’s employment. Restricted activity includes without
limitation accepting employment or a consulting position with any Person who is, or at any time within twelve (12) months prior to termination of the Executive’s employment has been, a Significant Customer (as defined below) of the Company
or any of its Affiliates. For the purposes of this Section 8, the business of the Company and its Affiliates shall include all Products and the Executive’s undertaking shall encompass all items, products and services that may be used in
substitution for Products. Notwithstanding anything to the contrary herein, the following shall not constitute a breach of this Section 8 (a): (i) ownership by Executive, as a 

 passive investment, of less than five percent (5%) of capital stock or equity of any corporation or other equity
that is publicly traded and (ii) continued passive ownership by the Executive of the same percentage of the outstanding equity interests in Transportation Designers Group, Ltd (such entity, the “Affiliated Fleet Owner”) as held by the
Executive on the date hereof provided that the size of the fleet owned by such Affiliated Fleet Owner shall not exceed the size of such fleet on the date hereof. For the purposes of this Section 8, “Significant Customer” shall mean
any major router of freight, including without limitation any third-party logistics provider. 
 (b) The Executive agrees that, during his
employment with the Company, he will not undertake any outside activity, whether or not competitive with the business of the Company or its Affiliates, that could reasonably give rise to a conflict of interest or otherwise interfere with his duties
and obligations to the Company or any of its Affiliates. 
 (c) The Executive further agrees that while he is employed by the Company and
during the Non-Competition Period, the Executive will not hire or attempt to hire any employee of the Company or any of its Affiliates, assist in such hiring by any Person, encourage any such employee to terminate his or her relationship with the
Company or any of its Affiliates, or solicit or encourage any customer or vendor of the Company or any of its Affiliates to terminate or diminish its relationship with them, or, in the case of a customer, to conduct with any Person any business or
activity which such customer conducts or could conduct with the Company or any of its Affiliates. 
 9. Notification Requirement
During the Non-Competition Period, the Executive shall give notice to the Company of each new business activity he plans to undertake, at least thirty (30) days prior to beginning any such activity For the period beginning on the last day of
the Non-Competition Period and continuing until the ninetieth (90th) day thereafter, the Executive shall give notice to the Company of each new business activity he plans to undertake, at least ten (10) days prior to beginning any such
activity. In each case, such notice shall state the name and address of the Person for whom such activity is undertaken and the nature of the Executive’s business relationship(s) and position(s) with such Person. The Executive shall provide the
Company with such other pertinent information concerning such business activity as the Company may reasonably request in order to determine the Executive’s continued compliance with his obligations under Sections 7 and 8 hereof. 
 10. Enforcement of Covenants. The Executive acknowledges that he has carefully read and considered all the terms and conditions of this Agreement,
including the restraints imposed upon him pursuant to Sections 7 and 8 hereof. The Executive agrees that said restraints are necessary for the reasonable and proper protection of the Company and its Affiliates and that each and every one of the
restraints is reasonable in respect to subject matter, length of time and geographic area. The Executive further acknowledges that, were he to breach any of the covenants contained in Sections 7 or 8 hereof, the damage to the Company would be
irreparable. The Executive therefore agrees that the Company, in addition to any other remedies available to it, shall be entitled to preliminary and permanent injunctive relief against any breach or threatened breach by the Executive of any of said
covenants, without having to post bond. The parties further agree that, in the event that any provision of Section 7 or 8 hereof shall be determined by any court of competent jurisdiction to be unenforceable by reason of its being extended over
too great a time, too large a geographic area or too great a range of activities, such provision shall be deemed to be modified to permit its enforcement to the maximum extent permitted by law. 

 11. Conflicting Agreements. The Executive hereby represents and warrants that the execution of
this Agreement and the performance of his obligations hereunder will not breach or be in conflict with any other agreement to which the Executive is a party or is bound and that the Executive is not now subject to any covenants against competition
or similar covenants or any court order or other legal obligation that would affect the performance of his obligations hereunder. The Executive will not disclose to or use on behalf of the Company any proprietary information of a third party without
such party’s consent. 
 12. Definitions. Words or phrases which are initially capitalized or are within quotation marks shall
have the meanings provided in this Section and as provided elsewhere herein. For purposes of this Agreement, the following definitions apply: 
 (a) “Affiliates” means all persons and entities directly or indirectly controlling, controlled by or under common control with the Company, where control may be by either management authority or equity interest. 
 (b) “Confidential Information” means any and all information of the Company and its Affiliates that is not generally known by others with whom
they compete or do business, or with whom any of them plans to compete or do business and any and all information, publicly known in whole or in part or not, which, if disclosed by the Company or its Affiliates would assist in competition against
them. Confidential Information includes without limitation such information relating to (i) the development, research, testing, manufacturing, marketing and financial activities of the Company and its Affiliates, (ii) the Products,
(iii) the costs, sources of supply, financial performance and strategic plans of the Company and its Affiliates, (iv) the identity and special needs of the customers of the Company and its Affiliates and (v) the people and
organizations with whom the Company and its Affiliates have business relationships and those relationships. Confidential Information also includes any information that the Company or any of its Affiliates have received, or may receive hereafter,
belonging to customers or others with any understanding, express or implied, that the information would not be disclosed. 
 (c)
“Person” means an individual, a corporation, a limited liability company, an association, a partnership, an estate, a trust and any other entity or organization, other than the Company or any of its Affiliates. 
 (d) “Products” mean all products planned, researched, developed, tested, manufactured, sold, licensed, leased or otherwise distributed or put
into use by the Company or any of its Affiliates, together with all services provided or planned by the Company or any of its Affiliates, during the Executive’s employment 
 13. Withholding. All payments made by the Company under this Agreement shall be reduced by any tax or other amounts required to be withheld by the
Company under applicable law. 
 14. Assignment. Neither the Company nor the Executive may make any assignment of this Agreement or
any interest herein, by operation of law or otherwise, without the prior written consent of the other; provided, however, that the Company may assign its rights and obligations under this Agreement without the consent of the Executive in the event
that the 

 Company shall hereafter affect a reorganization, consolidate with, or merge into, any Person or transfer all or
substantially all of its properties or assets to any Person. This Agreement shall inure to the benefit of and be binding upon the Company and the Executive, their respective successors, executors, administrators, heirs and permitted assigns.

 15. Severability. If any portion or provision of this Agreement shall to any extent be declared illegal or unenforceable by a court
of competent jurisdiction, then the remainder of this Agreement, or the application of such portion or provision in circumstances other than those as to which it is so declared illegal or unenforceable, shall not be affected thereby, and each
portion and provision of this Agreement shall be valid and enforceable to the fullest extent permitted by law. 
 16. Waiver. No
waiver of any provision hereof shall be effective unless made in writing and signed by the waiving party. The failure of either party to require the performance of any term or obligation of this Agreement, or the waiver by either party of any breach
of this Agreement, shall not prevent any subsequent enforcement of such term or obligation or be deemed a waiver of any subsequent breach. 
 17. Notices. Any and all notices, requests, demands and other communications provided for by this Agreement shall be in writing and shall be effective when delivered in person or deposited in the United States mail, postage prepaid,
registered or certified, and addressed to the Executive at his last known address on the books of the Company or, in the case of the Company, at its principal place of business, attention of the Chair of the Board, or to such other address as either
party may specify by notice to the other actually received. 
 18. Entire Agreement This Agreement constitutes the entire agreement
between the parties and supersedes all prior communications, agreements and understandings, written or oral, with respect to the terms and conditions of the Executive’s employment, including without limitation the document titled
“Employment Agreement” between the Executive and the Company dated January 1, 2005 
 19. Amendment. This Agreement may
be amended or modified only by a written instrument signed by the Executive and by an expressly authorized representative of the Company. 
 20. Headings. The headings and captions in this Agreement are for convenience only and in no way define or describe the scope or content of any provision of this Agreement. 
 21 Counterparts. This Agreement may be executed in two or more counterparts, each of which shall be an original and all of which together shall
constitute one and the same instrument. 
 22. Governing Law. This is an Ohio contract and shall be construed and enforced under and
be governed in all respects by the laws of the State of Ohio, without regard to the conflict of laws principles thereof. 
 24. Successor
and Assigns. This Agreement shall be binding upon and inure to the benefit of the parties hereto and their respective heirs and personal representatives. 

 IN WITNESS WHEREOF, this Agreement has been executed as a sealed instrument by the Company, by its duly
authorized representative, and by the Executive, as of the date first above written. 
  

							
	THE EXECUTIVE:	 		 	THE COMPANY
				
	 /s/ John J. Sliter
	 		 	By:	 	 /s/ Daniel K. Sokolowski

	John J. Sliter	 		 		 	Daniel K. Sokolowski
		 		 	Title:	 	Chief Executive OfficerTransition and Separation Agreement

 Exhibit 10.1 
 CONFIDENTIAL EMPLOYMENT TRANSITION & SEPARATION AGREEMENT 
 This Confidential Employment
Transition & Separation Agreement (the “Agreement”) is made by and between Renovis, Inc. (hereinafter, the “Company”) and Dushyant Pathak, Ph.D. (“Pathak”) (together referred to as
“the Parties”) and is entered into as of May 1, 2006 (the “Notice Date”), effective the eighth day after Pathak’s signature without revocation (the “Effective Date”). 
 WHEREAS, Pathak is employed by the Company as Vice President, Corporate Development; 
 WHEREAS, Pathak has informed the Company that he has decided to explore other opportunities outside of Renovis. 
 WHEREAS the Company desires to retain the services of Pathak during a transition period and Pathak has agreed to provide such services. 
 WHEREAS Pathak played a strong leadership role in our corporate development and program management functions since joining Renovis in early 2003. In
2002, before Pathak joined Renovis, he was an executive at Centaur Pharmaceuticals and played a central role on the other side of the table in our negotiations to acquire NXY-059. It was his professionalism and effectiveness as an advocate for
Centaur in those negotiations that inspired Renovis to seek his help when the deal was completed. Since that time, Pathak has become a Renovis executive and has made many important contributions, not the least of which was the key role he played in
negotiating and then managing our collaboration with Pfizer. 
 WHEREAS, Pathak has entered into with the Company an Amended and Restated
Employment Agreement dated April 8, 2005 (the “Employment Agreement”), an Employee Proprietary Information and Inventions Agreement dated April 15, 2003 (the “PIIA”) and an Indemnity Agreement dated
April 8, 2005 (the “Indemnity Agreement”) and the Company and Renovis have agreed to modify the Employment Agreement as specifically provided herein; 
 WHEREAS, the Company on January 14, 2003, March 18, 2003, August 22, 2003, September 24, 2003, February 9,
2005 and January 16, 2006 granted Pathak options to purchase an aggregate of Two Hundred Four Thousand Nine Hundred Ninety Nine (204,999) shares of the Company’s common stock (the “Stock Options”) subject to the terms
and conditions of the Company’s 2000 Equity Incentive Plan, 2003 Equity Incentive Plan, 2003 Stock Plan, and related amendments thereto, including any exhibits thereto (collectively, the “Plan”); 
 WHEREAS, Pathak has tendered his resignation, and the Company accepts such resignation effective as of November 30, 2006 (the “Separation
Date”); and 
 WHEREAS, the Parties agree that Pathak’s resignation qualifies as a “Constructive Termination” as
defined in Paragraph 11(d) (3) of the Employment Agreement. 

 D. Pathak 
 Confidential 
  Page
 2
 
  

 NOW THEREFORE, in consideration of the mutual promises made herein, the Parties hereby agree as
follows: 
 1. Employment/Transition. 
 a) Pathak’s employment as the Company’s Vice President, Corporate Development will terminate on November 30, 2006 or such earlier date as provided in writing by either party upon seven
(7) days’ advance written notice (the “Separation Date”), at which time Pathak will be paid all wages, including accrued, unused vacation, earned through the Separation Date. Notwithstanding the foregoing, the Company shall be
permitted to terminate Pathak’s employment prior to November 30, 2006 only for Pathak’s failure to comply with the provisions of this Agreement. Effective as of May 16, 2006 Pathak will no longer be an executive officer of the
Company. Following the Separation Date, Pathak shall not be eligible for the accrual of any employment benefits including, without limitation, paid vacation. The Company shall promptly reimburse Pathak for all business expenses incurred by him on or
before the Separation Date, in accordance with the terms of the Company’s policy regarding such reimbursements. 
 b)
From the Effective Date until the Separation Date (the “Transition Period”), Pathak will be available for not less than twenty hours per week to reasonably assist the Company’s Senior Executives and provide such transition
services as the Company may reasonably request, at mutually agreeable times, as needed during the Transition Period. Pathak will continue to report to the President & CEO, and his name, photograph, title and bio will remain as is on the
Company’s external website until the Separation Date, in a manner consistent with this reporting structure. Pathak may telecommute from home, unless otherwise requested to be on-site, through this Transition Period. The Company will maintain
and provide Pathak with access to his current corporate e-mail and phone through the Separation Date, and will extend to Pathak the use of the Company’s business facilities and administrative support as reasonably needed to provide transition
services to the Company during the Transition Period. The Company will promptly reimburse Pathak for pre-approved expenses incurred by him in providing any transition services, including but not limited to reimbursement for use of his cell phone as
currently reimbursed, in accordance with the Company’s expense reimbursement policies. As compensation for transition services provided by him, the Company shall continue to pay his base salary at the current rate and continue to vest his Stock
Options during the Transition Period. Pathak may provide business consultation to other companies and/or individuals during the Transition Period so long as provision of such services does not conflict or interfere with provision of transition
services to Company. If such consultation is to be provided to companies or individuals engaged in pharmaceutical research and/or development that is directly in competition with Company, then such consultation will be subject to the Company’s
prior approval, which approval the Company may withhold in its sole and absolute discretion. 
 2. Settlement Compensation.

 a) Cash. On January 1, 2007 or as soon as administratively practicable thereafter, if Pathak remains unemployed
on a full-time basis by any employer from the Separation Date through January 1, 2007, the Company will pay Pathak in a lump sum, less all applicable taxes and other authorized withholding, the equivalent of twelve (12) months of base
salary, less the amount of salary paid to Pathak during the period from May 16, 2006 through the Separation Date, plus ten thousand dollars ($10,000). On January 1, 2007 or as soon as administratively practicable thereafter, if Pathak
becomes employed on a, full-time basis during the period from the Separation Date through January 1, 2007, the Company will pay Pathak in a lump sum, less all applicable taxes and other authorized withholding, the pro-rata portion of twelve
(12) months of base salary, less the amount of salary paid to Pathak during the period from May 16, 2006 through the Separation Date. The payment shall be pro-rated based on the period of time he remained unemployed between the Separation
Date and January 1, 2007. If Pathak becomes employed on a, full-time basis during 

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the period from the Separation Date through January 1, 2007, then the ten thousand dollar ($10,000) payment provided for by this Paragraph shall be
reduced to five thousand dollars ($5,000.00). 
 b) COBRA. Health coverage shall end on the Separation Date.
Thereafter, Pathak may elect to continue to participate in the Company’s group health insurance plans pursuant to COBRA. If Pathak elects COBRA coverage, the Company shall pay his COBRA payments for six full months after his Separation Date, as
long as he is not employed on a full-time basis, from the Separation Date through January 1, 2007. Thereafter, Pathak shall be responsible for such payments through the end of the COBRA election period as established under federal law. If
Pathak elects COBRA coverage, and becomes employed between the Separation Date and January 1, 2007, the Company shall pay his COBRA payments for the pro-rata portion of six full months after his Separation Date based on the period of time he
remained unemployed on a, full-time basis between the Separation Date and January 1, 2007. Thereafter, Pathak shall be responsible for such payments through the end of the COBRA election period as established under federal law. 
 c) Stock Option Vesting and Acceleration of Stock Option Vesting. The Parties agree that Pathak will have already vested as of the
Notice Date in One Hundred One Thousand Six Hundred Seventy Five (101,675) shares of common stock under the Stock Options (i.e., the Stock Options have vested and become exercisable with respect to an aggregate of 81,885 shares of common stock,
101,675 vested less 19,790 already exercised). The Parties further agree that Pathak will have already vested as of the Separation Date in One Hundred Twenty Nine Thousand Nine Hundred Forty Eight (129,948) shares of common stock under the
Stock Options (i.e., the Stock Options have vested and become exercisable with respect to an aggregate of 61,547 shares of common stock, 129,948 vested less 68,401 already exercised). The Parties further agree that as part of the Settlement
Compensation, Pathak will additionally vest in Twenty Two Thousand Five Hundred Seventy One (22,571) shares of common stock under the Stock Options, such vesting to occur immediately upon the Separation Date. After taking into account the
foregoing accelerated vesting, and that provided for by Paragraph 1(b), above, Pathak shall have vested in a total of One Hundred Fifty Two Thousand Five Hundred Nineteen (152,519) shares of the Stock Options as of the Separation Date,
allocated by stock option grant in accordance with Exhibit A hereto. 
 i) If Pathak remains employed with the Company through
October 3, 2006, then Pathak will have until December 31, 2007 to exercise his vested Stock Options. However, if Pathak separates from the Company earlier than this date, then Pathak will have until December 31, 2006 to exercise his
vested Stock Options. 
 ii) From the date of this Agreement through the Separation Date, Pathak shall strictly comply with
the Company’s Insider Trading Policy, including, among other things, clearing all trades in Company stock with the Company’s Compliance Officer. 
 iii) Promptly after any exercise by Pathak of any Stock Options, one or more certificates representing the shares with respect to which such Stock Options were exercised shall be delivered to Pathak and shall be
subject to such legends as are consistent with the agreements to which Pathak is a party and the Securities Act of 1933, as amended. If, prior to the Separation Date, Pathak sells Stock Options through either or both of his 10b5-1 Trading Plans, the
Stock Options shall be electronically 

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transmitted to Merrill Lynch and shall be subject to such legends as are consistent with the agreements to which Pathak is a party and the Securities Act of
1933, as amended. 
 iv) The Rule 10b5-1 Trading Plans entered into by Pathak, effective as of March 18, 2005, shall
expire upon June 13, 2006 or the Separation Date, whichever date occurs first, by its terms, in accordance with the terms of Paragraph 4(g) of the respective 10b5-1 Trading Plan documents. The Rule 10b5-1 Trading Plan entered into by Pathak,
effective as of March 8, 2006, shall expire upon the Separation Date, in accordance with the terms of Paragraph 4(g) of the respective 10b5-1 Trading Plan documents. 
 v) Except as expressly provided herein, all of the Stock Options shall continue to be subject to all the other terms of the Plan and the
option agreements. 
 d) Professional Development & Outplacement Support. The Company will pay for
Pathak’s participation in professional development and outplacement programs of his choice, in an amount not to exceed $15,000 (fifteen thousand dollars). Said professional development and outplacement programs shall be identified by Pathak no
later than three months after the Separation Date, and must commence prior to December 31, 2007,. Cost for such programs shall be invoiced to and paid directly by the Company to the vendor no later than March 15, 2007. All professional
development and outplacement programs to be reimbursed by the Company pursuant to this Paragraph 2(d) are subject to pre-approval by the Company, which approval shall not be unreasonably withheld. 
 e) No Other Benefits. Pathak understands and acknowledges that he shall be entitled to no settlement benefits from the Company
other than those expressly set forth in this Section 2. 
 3. Releases of Claims. 
 a) Pathak agrees that the Company’s obligations in this Agreement represents settlement in full of all outstanding obligations owed
to Pathak by (and any and all actual and/or potential claims by Pathak against) the Company and its predecessors, successors, divisions, subsidiaries, officers, managers, supervisors, agents and employees. Pathak hereby fully and forever releases
the Company and its officers, directors, employees, agents, investors, shareholders, administrators, affiliates, divisions, subsidiaries, predecessor and successor corporations, and assigns (“collectively, the Company Releasees”), from,
and agrees not to sue concerning, or in any manner to institute, prosecute or pursue (except to enforce the Agreement and related surviving rights), any claim, complaint, charge, duty, obligation or cause of action relating to any matters of any
kind, whether presently known or unknown, suspected or unsuspected, that Pathak may possess against any of the Company Releasees arising from any omissions, acts or facts that have occurred up until and including the Effective Date of this
Agreement. 
 b) The Company, on its own behalf, and (to the fullest extent allowed) on behalf of its, divisions,
subsidiaries, affiliates, predecessor and successor corporations, and assigns hereby fully and forever releases Pathak and his respective heirs, family members, and executors, agents, attorneys and assigns (collectively, the “Pathak
Releasees”), from, and agrees not to sue concerning, or in any manner to institute, prosecute or pursue, any claim, complaint, charge, duty, obligation or cause of action relating to any matters of any kind, that the Company and/or the Company
Releasees may possess against Pathak and/or any 

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of the Pathak Releasees, arising from any omissions, acts or facts that have occurred up until and including the Effective Date of this Agreement and that
are known, or in the exercise of reasonable diligence should be known to, the Company’s Board of Directors. 
 c) The
above releases include, without limitation: 
 i) any and all claims relating to or arising out of Pathak’s employment
relationship with the Company and the termination of that relationship (except for any claims for indemnity arising under California law, the indemnification provisions of the Company’s Certificate of Incorporation and Bylaws and the Indemnity
Agreement); 
 ii) any and all claims relating to, or arising from, Pathak’s right to purchase, or actual purchase of
shares of stock of the Company; 
 iii) any and all claims for wrongful discharge of employment; termination in violation of
public policy; discrimination; harassment; retaliation; breach of contract, both express and implied; breach of a covenant of good faith and fair dealing, both express and implied; promissory estoppel; negligent or intentional infliction of
emotional distress; negligent or intentional misrepresentation; negligent or intentional interference with contract or prospective economic advantage; unfair business practices; defamation; libel; slander; negligence; personal injury; assault;
battery; invasion of privacy; false imprisonment; conversion; 
 iv) any and all claims for violation of any federal, state or
municipal statute, including, but not limited to, Title VII of the Civil Rights Act of 1964; the Civil Rights Act of 1991; the Americans with Disabilities Act of 1990; the Fair Labor Standards Act; the Employee Retirement Income Security Act of
1974; the Worker Adjustment and Retraining Notification Act; the Family and Medical Leave Act; the California Family Rights Act; the California Fair Employment and Housing Act; and the California Labor Code; 
 v) any and all claims for violation of the federal, or any state, constitution; 
 vi) any and all claims arising out of any other laws and regulations relating to employment or employment discrimination; 
 vii) any claim for any loss, cost, damage, or expense arising out of any dispute over either the non-withholding or other tax treatment
only of any of the proceeds paid to Pathak as a result of this Agreement; and 
 viii) any and all claims for attorneys’
fees and costs, not paid herein. 
 d) The Parties agree that the releases set forth in this Paragraph 4 shall be and remain
in effect in all respects as complete general releases as to the matters released. These releases expressly do not extend to any obligations incurred under (or excepted in) this Agreement. 

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 e) In accordance with the Older Workers Benefit Protection Act of 1990, Pathak
confirms that he has been advised of and is aware of the following: 
 ix) He has the right to consult with an attorney before
signing this Agreement; 
 x) He has twenty-one (21) days from the date he receives a copy of this Agreement to consider
it; 
 xi) He may waive the above-described twenty-one (21) day notice period by signing this Agreement prior to the
expiration of the notice period; and 
 xii) He has seven (7) days after signing this Agreement to revoke his acceptance
of it, and this Agreement will not be effective until that revocation period has expired. 
 4. Civil Code Section 1542 Waivers;
Release Exceptions. 
 Pathak represents that he is not aware of any claim by him or by the Pathak Releasees against any of the Company
Releasees other than the claims that are released by this Agreement. The Company represents that it is not aware of any claim by it or any other third party against any of the Pathak Releasees other than the claims that are released by this
Agreement. Each Party acknowledges that he/it has been advised by legal counsel and is familiar with the provisions of California Civil Code Section 1542, which provides as follows: 
 A GENERAL RELEASE DOES NOT EXTEND TO 
 CLAIMS WHICH THE CREDITOR DOES NOT 
 KNOW OR SUSPECT TO EXIST IN HIS OR HER 
 FAVOR AT THE TIME OF EXECUTING THE 
 RELEASE, WHICH IF KNOWN BY HIM OR HER 
 MUST HAVE MATERIALLY AFFECTED HIS OR 
 HER SETTLEMENT WITH THE DEBTOR. 
 Each Party, being aware of said code section, agrees to expressly waive any rights he/it may have there under, as well as under any other statute or common law principles of similar effect. Nevertheless, none of the waivers and releases in
this Agreement shall waive, release, apply to and/or limit in any way either: (1) Pathak’s legally-vested rights (if any) earned through the Separation Date under any benefit plan of the Company (e.g., the Plan, 401(k) plan, group medical,
dental, vision and life insurance benefit plans), pursuant to any Company insurance policy(ies), and/or that are not waivable under applicable law (e.g., regarding unemployment, workers compensation, or ERISA); (2) Pathak’s right to
indemnification, and to a defense from the Company, and to be held harmless by the Company pursuant to the Indemnity Agreement and any applicable insurance policy(ies), statute(s), common law obligation(s), or otherwise; (3) claims that the
Company has against Pathak arising out of Pathak’s employment by the Company or the separation thereof based upon facts not known to, except for those that in the exercise of reasonable diligence should be known to, the Board of Directors of
the Company as of the Effective Date; (4) Pathak’s right to bring to the attention of the Equal Employment Opportunity Commission claims of discrimination; provided, however, that Pathak does release his right to secure any damages for
alleged discriminatory treatment; (5) either Party’s rights to enforce the Agreement; and (6) either Party’s rights to raise claims for the other Party’s (and associated releasees’) post-Separation Date activities.

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 5. Successors and Assigns. 
 This Agreement shall be binding upon the parties hereto and upon their heirs, administrators, representatives, executors, successors and assigns, and
shall inure to the benefit of said parties and each of them and their heirs, administrators, representatives, executors, successors and assigns. 
 6. Confidential Information; Return of Company Property. 
 a) Pathak hereby expressly confirms his continuing
obligations to the Company pursuant to the Employee Proprietary Information and Inventions Agreement executed by Pathak on April 15, 2003 (the “Confidentiality Agreement”). 
 b) Pathak shall deliver to the Company upon the Separation Date all originals and copies of correspondence, drawings, manuals, letters,
notes, notebooks, reports, programs, plans, proposals, financial documents, or any other documents concerning the Company’s customers, business plans, marketing strategies, products, processes or business of any kind and/or which contain
proprietary information or trade secrets which are in the possession or control of Pathak or his agents or representatives. 
 c) Pathak shall return to the Company on the Separation Date all equipment of the Company in his possession or control. Notwithstanding the foregoing, Pathak shall be allowed to retain his Company-issued laptop computer, Treo 650 cell phone
and a Linksys wireless router, after the Company has removed from them all Company information. 
 7. No Cooperation. 
 Pathak agrees that he will not act in any manner that is intended to (and does) materially damage the business of the Company. The Company agrees that it
will not act in any manner that is intended to (and does) materially damage Pathak. Each Party further agrees that he/it will not knowingly counsel or assist any attorneys or their clients in the presentation or prosecution of any disputes,
differences, grievances, claims, charges, or complaints by any third party against the other Party, unless involuntarily under a subpoena or other court order to do so. Each Party agrees both to immediately notify the other Party upon receipt of any
such subpoena or court order related in any way to Pathak’s Company employment, and to furnish, within three (3) business days of its receipt, a copy of such subpoena or court order to the other Party. If approached by anyone for counsel
or assistance in the presentation or prosecution of any disputes, differences, grievances, claims, charges, or complaints by those third parties against the other Party, the contacted Party shall state no more than that he/it cannot provide counsel
or voluntary assistance. 
  

	 	8.	Cooperation in Future Investigations or Litigation. 

 Pathak agrees, to the extent practical, to give reasonable cooperation, at the Company’s request, in any pending or future litigation, arbitration or administrative proceeding or inquiry brought against the Company, and in any
investigation the Company may conduct. Pathak shall be reimbursed for all out of pocket expenses incurred by him in compliance with this paragraph. Notwithstanding the foregoing, the Company shall have no obligation to pay Pathak for time spent and
expenses incurred by him in any pending or future litigation or arbitration which Pathak has initiated or which has been initiated on his behalf. 

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 9. Non-Disparagement. 
 Pathak agrees to refrain from any defamation, libel or slander of the Company, and any tortious interference with the contracts, relationships and
prospective economic advantage of the Company. The Company agrees to refrain from any defamation, libel or slander of Pathak, and any tortious interference with the contracts, relationships and prospective economic advantage of Pathak. 

10. No Admission of Liability. 
 Each Party understands and acknowledges that this Agreement constitutes a compromise and settlement of any and all potential disputed claims. No action taken by either Party, either previously or in connection with this Agreement, shall be
deemed or construed to be: (a) an admission of the truth or falsity of any potential claims; or (b) an acknowledgment or admission by either Party of any fault or liability whatsoever to the other Party or to any third party. 

11. Costs. 
 The Parties shall
each bear their own costs, attorneys’ fees and other fees incurred in connection with the preparation of this Agreement. 
 12.
Authority.  
 The Company represents and warrants that the undersigned have the authority to act on behalf of the Company and to bind
the Company and all who may claim through it to the terms and conditions of this Agreement. Pathak represents and warrants that he has the capacity to act on his own behalf and on behalf of all who might claim through him to bind them to the terms
and conditions of this Agreement. Each Party warrants and represents that there are no liens or claims of lien or assignments in law or equity or otherwise of or against any of the claims or causes of action released herein. 
 13. No Representations. 
 Each Party
represents that he/it has consulted with or has had the opportunity to consult with an attorney, and has carefully read and understands the scope and effect of the provisions of this Agreement. Each Party has not relied upon any representations or
statements made by the other Party or that Party’s agents which are not specifically set forth in this Agreement. 
 14.
Severability. 
 In the event that any provision or any portion of any provision hereof becomes or is declared by a court of competent
jurisdiction to be illegal, unenforceable or void, this Agreement shall continue in full force and effect without said provision or portion of provision. 
 15. Attorneys’ Fees. 
 In the event that either Party brings an action to enforce or effect its
rights under this Agreement, the prevailing party shall be entitled to recover its costs and expenses, including the costs of mediation, arbitration, litigation, court fees, etc., plus reasonable attorneys’ fees, incurred in connection with any
such an action. 

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 16. Entire Agreement. 
 This Agreement and the surviving terms of the other agreements referenced in it (as modified by this Agreement) represent the entire agreement and
understanding between the Company and Pathak concerning Pathak’s separation from the Company and the events leading thereto and associated therewith, and otherwise supersedes and replaces any and all prior agreements and understandings
concerning Pathak’s relationship with the Company. 
 17. No Oral Modification. 
 This Agreement may only be amended in writing signed by Pathak and a duly authorized officer of the Company. 
 18. Governing Law. 
 This Agreement
shall be governed by the laws of the State of California, without regard for choice of law provisions. 
 19. Dispute Resolution.

 Unless otherwise prohibited by law or specified below, all disputes, claims, and causes of action (including but not limited to any claims
of statutory discrimination of any type), in law or equity, arising from or relating to this Agreement or its enforcement, performance, breach, or interpretation, or to Pathak’s employment with the Company or the termination of that employment,
shall be resolved solely and exclusively by final, binding and confidential arbitration before a single neutral arbitrator through Judicial Arbitration & Mediation Services/Endispute, Inc. (“JAMS”) under the then existing JAMS
arbitration rules. Pathak understands and agrees that this provision waives his right to a jury trial on these claims. This arbitration shall be held in a mutually agreeable location or, if the parties are unable to agree, a location selected by
JAMS. Nothing in this section is intended to prevent either party from obtaining injunctive relief in court to prevent irreparable harm pending the conclusion of any such arbitration. 
 20. Counterparts Facsimile. 
 This
Agreement may be executed in counterparts and by facsimile, and each counterpart and facsimile shall have the same force and effect as an original and shall constitute an effective, binding agreement on the part of each of the undersigned, upon
receipt of the original or faxed copy of the counterpart signed by the other Party’s legal counsel. 
 21. Voluntary Execution of
Agreement. This Agreement is executed voluntarily and without any duress or undue influence on the part or behalf of the Parties hereto, with the full intent of releasing all claims. The Parties acknowledge that: 
 a) They have read this Agreement; 
 b) They have been represented in the preparation, negotiation, and execution of this Agreement by legal counsel of their own choice; 

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 c) They understand the terms and consequences of this Agreement and of the releases
it contains; 
 d) They are fully aware of the legal and binding effect of this Agreement; and 
 e) This Agreement shall be binding upon the Parties and their respective agents, successors, representatives, heirs, administrators and
assigns. 
 IN WITNESS WHEREOF, the Parties have executed this Agreement on the respective dates set forth below. 
  

									
		 		 	 RENOVIS, INC.

				
	 Dated: May 23, 2006
	 		 	 By:
	 	 /s/ Corey Goodman

		 		 		 		 	 Corey Goodman, President and CEO

				
	 Dated: May 23, 2006
	 		 		 	 /s/ Dushyant Pathak

		 		 		 		 	 Dushyant Pathak

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 Exhibit A 
 STOCK OPTION VESTING AND ACCELERATION OF STOCK OPTION VESTING 
  

					
	 May 1, 2006
	  	Shares Vested as of Notice Date	  	101, 675
	 May 16, 2006
	  	Shares Vested Notice Date to 5/16/06	  	2,603
	 November 30, 2006
	  	Additional shares vested through Transition Period / Separation Date	  	25,670
		  	SUBTOTAL	  	129,948
	 May 31, 2007
	  	Additional shares accelerated vesting	  	22,571
		  	TOTAL	  	152,519
			
	 Current Grant Type *
	  	 Grant Date
	  	 Vested Allocation **

	 NQ
	  	1/14/2003	  	11,111
	 ISO
	  	3/18/2003	  	40,000
	 ISO
	  	8/22/2003	  	34,374
	 ISO
	  	9/24/2003	  	1,120
	 NQ
	  	9/24/2003	  	28,416
	 ISO
	  	2/9/2005	  	20,441
	 NQ
	  	2/9/2005	  	2,058
	 ISO
	  	1/16/2006	  	0
	 NQ
	  	1/16/2006	  	14,999

  

	*	ISO status changes to NQ after 90 days from Separation Date. Also, any ISOs exceeding the IRS ISO limit will be converted to NQs upon acceleration 

  

	**	All vested share amounts include 68,401 option shares previously exercised on or before May 3, 2006.

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